## Database	ID	URL or Descriptions
# AltName	CLIC4_HUMAN	Intracellular chloride ion channel protein p64H1
# BioGrid	117431	47
# ChiTaRS	CLIC4	human
# DOMAIN	CLIC4_HUMAN	Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion. {ECO 0000269|PubMed 16581025}. 
# Ensembl	ENST00000374379	ENSP00000363500; ENSG00000169504
# Ensembl	ENST00000488683	ENSP00000436538; ENSG00000169504
# ExpressionAtlas	Q9Y696	baseline and differential
# FUNCTION	CLIC4_HUMAN	Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell- surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical- basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). {ECO 0000269|PubMed 12163372, ECO 0000269|PubMed 14569596, ECO 0000269|PubMed 16176272, ECO 0000269|PubMed 16239224, ECO 0000269|PubMed 18302930, ECO 0000269|PubMed 19247789}. 
# GO_component	GO:0005622	intracellular; IDA:LIFEdb.
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005813	centrosome; IDA:UniProtKB.
# GO_component	GO:0005829	cytosol; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005902	microvillus; IDA:UniProtKB.
# GO_component	GO:0005911	cell-cell junction; IDA:UniProtKB.
# GO_component	GO:0009986	cell surface; IDA:UniProtKB.
# GO_component	GO:0015629	actin cytoskeleton; TAS:UniProtKB.
# GO_component	GO:0016363	nuclear matrix; IDA:UniProtKB.
# GO_component	GO:0030496	midbody; IDA:UniProtKB.
# GO_component	GO:0030659	cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0045177	apical part of cell; IDA:UniProtKB.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005244	voltage-gated ion channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0005254	chloride channel activity; TAS:ProtInc.
# GO_process	GO:0001525	angiogenesis; IBA:GO_Central.
# GO_process	GO:0001886	endothelial cell morphogenesis; IEA:Ensembl.
# GO_process	GO:0006821	chloride transport; NAS:UniProtKB.
# GO_process	GO:0006915	apoptotic process; IEA:InterPro.
# GO_process	GO:0007035	vacuolar acidification; IEA:Ensembl.
# GO_process	GO:0009566	fertilization; IEA:Ensembl.
# GO_process	GO:0030154	cell differentiation; TAS:UniProtKB.
# GO_process	GO:0030216	keratinocyte differentiation; IMP:UniProtKB.
# GO_process	GO:0030336	negative regulation of cell migration; IDA:UniProtKB.
# GO_process	GO:0035088	establishment or maintenance of apical/basal cell polarity; NAS:UniProtKB.
# GO_process	GO:0035264	multicellular organism growth; IEA:Ensembl.
# GO_process	GO:0048754	branching morphogenesis of an epithelial tube; IEA:Ensembl.
# GO_process	GO:0051493	regulation of cytoskeleton organization; NAS:UniProtKB.
# GO_process	GO:0061299	retina vasculature morphogenesis in camera-type eye; IEA:Ensembl.
# GO_process	GO:0071277	cellular response to calcium ion; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005622	intracellular
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005815	microtubule organizing center
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005856	cytoskeleton
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0000902	cell morphogenesis
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0008219	cell death
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0040007	growth
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048646	anatomical structure formation involved in morphogenesis
# Gene3D	1.20.1050.10	-; 1.
# Gene3D	3.40.30.10	-; 1.
# Genevisible	Q9Y696	HS
# HGNC	HGNC:13518	CLIC4
# INDUCTION	CLIC4_HUMAN	Up-regulated by calcium ions in differentiating keratinocytes. Up-regulated in myofibroblasts. {ECO 0000269|PubMed 12163372, ECO 0000269|PubMed 17636002}. 
# IntAct	Q9Y696	5
# InterPro	IPR002946	CLIC
# InterPro	IPR010987	Glutathione-S-Trfase_C-like
# InterPro	IPR012336	Thioredoxin-like_fold
# InterPro	IPR030257	CLIC-4
# KEGG_Brite	ko04040	Ion channels
# MIM	606536	gene
# Organism	CLIC4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11260:SF185	PTHR11260:SF185; 2
# PDB	2AHE	X-ray; 1.80 A; A=1-251
# PDB	2D2Z	X-ray; 2.20 A; A/B/C=1-253
# PDB	3OQS	X-ray; 2.00 A; B=198-207
# PIR	T17226	T17226
# PRINTS	PR01263	INTCLCHANNEL
# PROSITE	PS50405	GST_CTER
# Proteomes	UP000005640	Chromosome 1
# RecName	CLIC4_HUMAN	Chloride intracellular channel protein 4
# RefSeq	NP_039234	NM_013943.2
# SIMILARITY	Belongs to the chloride channel CLIC family. {ECO	0000305}. 
# SIMILARITY	Contains 1 GST C-terminal domain. {ECO	0000305}. 
# SUBCELLULAR LOCATION	CLIC4_HUMAN	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. Nucleus matrix. Cell membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. Mitochondrion. Cell junction. Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles. 
# SUBUNIT	CLIC4_HUMAN	Component of a multimeric complex consisting of several cytoskeletal proteins, including actin, ezrin, alpha-actinin, gelsolin, IQGAP1 and CLIC5A. Binds directly to brain dynamin I in a complex containing actin, tubulin and 14-3-3 isoforms. Monomer. Interacts with HRH3. Interacts with AKAP9. {ECO 0000269|PubMed 10793131, ECO 0000269|PubMed 12163479, ECO 0000269|PubMed 16176272, ECO 0000269|PubMed 18302930}. 
# SUPFAM	SSF47616	SSF47616
# SUPFAM	SSF52833	SSF52833
# TCDB	1.A.12.1	the intracellular chloride channel (clic) family
# TIGRFAMs	TIGR00862	O-ClC
# TISSUE SPECIFICITY	CLIC4_HUMAN	Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle. {ECO 0000269|PubMed 10793131, ECO 0000269|PubMed 17200346, ECO 0000269|PubMed 17636002}. 
# UCSC	uc001bjo	human
# WEB RESOURCE	CLIC4_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/CLIC4ID40102ch1p36.html";
# eggNOG	ENOG410ZRK6	LUCA
# eggNOG	KOG1422	Eukaryota
BLAST	swissprot:CLIC4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CLIC4_HUMAN
BioCyc	ZFISH:ENSG00000169504-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000169504-MONOMER
COXPRESdb	25932	http://coxpresdb.jp/data/gene/25932.shtml
CleanEx	HS_CLIC4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CLIC4
DOI	10.1002/cm.10141	http://dx.doi.org/10.1002/cm.10141
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1007/s10456-009-9139-3	http://dx.doi.org/10.1007/s10456-009-9139-3
DOI	10.1016/S0002-9440(10)64203-4	http://dx.doi.org/10.1016/S0002-9440(10)64203-4
DOI	10.1016/j.bbrc.2006.03.099	http://dx.doi.org/10.1016/j.bbrc.2006.03.099
DOI	10.1016/j.bbrc.2008.02.071	http://dx.doi.org/10.1016/j.bbrc.2008.02.071
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1074/jbc.M112277200	http://dx.doi.org/10.1074/jbc.M112277200
DOI	10.1074/jbc.M506724200	http://dx.doi.org/10.1074/jbc.M506724200
DOI	10.1074/mcp.M111.015131	http://dx.doi.org/10.1074/mcp.M111.015131
DOI	10.1091/mbc.11.5.1509	http://dx.doi.org/10.1091/mbc.11.5.1509
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1101/gr.GR1547R	http://dx.doi.org/10.1101/gr.GR1547R
DOI	10.1111/j.1742-4658.2005.04909.x	http://dx.doi.org/10.1111/j.1742-4658.2005.04909.x
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1158/1078-0432.CCR-06-1562	http://dx.doi.org/10.1158/1078-0432.CCR-06-1562
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1242/jcs.002741	http://dx.doi.org/10.1242/jcs.002741
EMBL	AF097330	http://www.ebi.ac.uk/ena/data/view/AF097330
EMBL	AF109196	http://www.ebi.ac.uk/ena/data/view/AF109196
EMBL	AL117424	http://www.ebi.ac.uk/ena/data/view/AL117424
EMBL	BC012444	http://www.ebi.ac.uk/ena/data/view/BC012444
Ensembl	ENST00000374379	http://www.ensembl.org/id/ENST00000374379
Ensembl	ENST00000488683	http://www.ensembl.org/id/ENST00000488683
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005813
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005902
GO_component	GO:0005911	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005911
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0015629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015629
GO_component	GO:0016363	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016363
GO_component	GO:0030496	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030496
GO_component	GO:0030659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030659
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0045177	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045177
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005244
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_process	GO:0001525	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001525
GO_process	GO:0001886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001886
GO_process	GO:0006821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006821
GO_process	GO:0006915	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006915
GO_process	GO:0007035	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007035
GO_process	GO:0009566	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009566
GO_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GO_process	GO:0030216	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030216
GO_process	GO:0030336	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030336
GO_process	GO:0035088	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035088
GO_process	GO:0035264	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035264
GO_process	GO:0048754	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048754
GO_process	GO:0051493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051493
GO_process	GO:0061299	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061299
GO_process	GO:0071277	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071277
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005815	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005815
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0000902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000902
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0008219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0040007	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040007
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048646	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048646
Gene3D	1.20.1050.10	http://www.cathdb.info/version/latest/superfamily/1.20.1050.10
Gene3D	3.40.30.10	http://www.cathdb.info/version/latest/superfamily/3.40.30.10
GeneCards	CLIC4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CLIC4
GeneID	25932	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25932
GeneTree	ENSGT00550000074477	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074477
HGNC	HGNC:13518	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13518
HOGENOM	HOG000231548	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231548&db=HOGENOM6
HOVERGEN	HBG050994	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050994&db=HOVERGEN
HPA	HPA008019	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA008019
HPA	HPA060804	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA060804
InParanoid	Q9Y696	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y696
IntAct	Q9Y696	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9Y696*
InterPro	IPR002946	http://www.ebi.ac.uk/interpro/entry/IPR002946
InterPro	IPR010987	http://www.ebi.ac.uk/interpro/entry/IPR010987
InterPro	IPR012336	http://www.ebi.ac.uk/interpro/entry/IPR012336
InterPro	IPR030257	http://www.ebi.ac.uk/interpro/entry/IPR030257
Jabion	25932	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=25932
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:25932	http://www.genome.jp/dbget-bin/www_bget?hsa:25932
KEGG_Orthology	KO:K05024	http://www.genome.jp/dbget-bin/www_bget?KO:K05024
MIM	606536	http://www.ncbi.nlm.nih.gov/omim/606536
MINT	MINT-3087884	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3087884
OMA	IWKYLNN	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IWKYLNN
OrthoDB	EOG091G0IHT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0IHT
PANTHER	PTHR11260:SF185	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11260:SF185
PDB	2AHE	http://www.ebi.ac.uk/pdbe-srv/view/entry/2AHE
PDB	2D2Z	http://www.ebi.ac.uk/pdbe-srv/view/entry/2D2Z
PDB	3OQS	http://www.ebi.ac.uk/pdbe-srv/view/entry/3OQS
PDBsum	2AHE	http://www.ebi.ac.uk/pdbsum/2AHE
PDBsum	2D2Z	http://www.ebi.ac.uk/pdbsum/2D2Z
PDBsum	3OQS	http://www.ebi.ac.uk/pdbsum/3OQS
PRINTS	PR01263	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01263
PROSITE	PS50405	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50405
PSORT	swissprot:CLIC4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CLIC4_HUMAN
PSORT-B	swissprot:CLIC4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CLIC4_HUMAN
PSORT2	swissprot:CLIC4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CLIC4_HUMAN
PharmGKB	PA26591	http://www.pharmgkb.org/do/serve?objId=PA26591&objCls=Gene
Phobius	swissprot:CLIC4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CLIC4_HUMAN
PhylomeDB	Q9Y696	http://phylomedb.org/?seqid=Q9Y696
ProteinModelPortal	Q9Y696	http://www.proteinmodelportal.org/query/uniprot/Q9Y696
PubMed	10070163	http://www.ncbi.nlm.nih.gov/pubmed/10070163
PubMed	10191309	http://www.ncbi.nlm.nih.gov/pubmed/10191309
PubMed	10793131	http://www.ncbi.nlm.nih.gov/pubmed/10793131
PubMed	11230166	http://www.ncbi.nlm.nih.gov/pubmed/11230166
PubMed	12163372	http://www.ncbi.nlm.nih.gov/pubmed/12163372
PubMed	12163479	http://www.ncbi.nlm.nih.gov/pubmed/12163479
PubMed	14569596	http://www.ncbi.nlm.nih.gov/pubmed/14569596
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16176272	http://www.ncbi.nlm.nih.gov/pubmed/16176272
PubMed	16239224	http://www.ncbi.nlm.nih.gov/pubmed/16239224
PubMed	16581025	http://www.ncbi.nlm.nih.gov/pubmed/16581025
PubMed	17200346	http://www.ncbi.nlm.nih.gov/pubmed/17200346
PubMed	17636002	http://www.ncbi.nlm.nih.gov/pubmed/17636002
PubMed	18302930	http://www.ncbi.nlm.nih.gov/pubmed/18302930
PubMed	19247789	http://www.ncbi.nlm.nih.gov/pubmed/19247789
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	22223895	http://www.ncbi.nlm.nih.gov/pubmed/22223895
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
RefSeq	NP_039234	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_039234
SMR	Q9Y696	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9Y696
STRING	9606.ENSP00000363500	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000363500&targetmode=cogs
SUPFAM	SSF47616	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47616
SUPFAM	SSF52833	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833
TCDB	1.A.12.1	http://www.tcdb.org/search/result.php?tc=1.A.12.1
TIGRFAMs	TIGR00862	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00862
UCSC	uc001bjo	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001bjo&org=rat
UniGene	Hs.440544	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.440544
UniProtKB	CLIC4_HUMAN	http://www.uniprot.org/uniprot/CLIC4_HUMAN
UniProtKB-AC	Q9Y696	http://www.uniprot.org/uniprot/Q9Y696
charge	swissprot:CLIC4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CLIC4_HUMAN
eggNOG	ENOG410ZRK6	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZRK6
eggNOG	KOG1422	http://eggnogapi.embl.de/nog_data/html/tree/KOG1422
epestfind	swissprot:CLIC4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CLIC4_HUMAN
garnier	swissprot:CLIC4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CLIC4_HUMAN
helixturnhelix	swissprot:CLIC4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLIC4_HUMAN
hmoment	swissprot:CLIC4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CLIC4_HUMAN
iep	swissprot:CLIC4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CLIC4_HUMAN
inforesidue	swissprot:CLIC4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CLIC4_HUMAN
neXtProt	NX_Q9Y696	http://www.nextprot.org/db/entry/NX_Q9Y696
octanol	swissprot:CLIC4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CLIC4_HUMAN
pepcoil	swissprot:CLIC4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CLIC4_HUMAN
pepdigest	swissprot:CLIC4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CLIC4_HUMAN
pepinfo	swissprot:CLIC4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CLIC4_HUMAN
pepnet	swissprot:CLIC4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CLIC4_HUMAN
pepstats	swissprot:CLIC4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CLIC4_HUMAN
pepwheel	swissprot:CLIC4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CLIC4_HUMAN
pepwindow	swissprot:CLIC4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CLIC4_HUMAN
sigcleave	swissprot:CLIC4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CLIC4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CAHM2_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9HA72-1; Sequence=Displayed; Name=2; IsoId=Q9HA72-2; Sequence=VSP_013853, VSP_013854; Note=No experimental confirmation available.; Name=3; IsoId=Q9HA72-3; Sequence=VSP_013856, VSP_013855; Note=No experimental confirmation available.; 
# AltName	CAHM2_HUMAN	Protein FAM26B
# CCDS	CCDS7549	-. [Q9HA72-1]
# ChiTaRS	CALHM2	human
# Ensembl	ENST00000260743	ENSP00000260743; ENSG00000138172. [Q9HA72-1]
# Ensembl	ENST00000369788	ENSP00000358803; ENSG00000138172. [Q9HA72-1]
# FUNCTION	CAHM2_HUMAN	Pore-forming subunit of a voltage-gated ion channel. {ECO 0000250}. 
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0005261	cation channel activity; IBA:GO_Central.
# GO_process	GO:0034220	ion transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9HA72	HS
# HGNC	HGNC:23493	CALHM2
# InterPro	IPR029569	FAM26
# InterPro	IPR029570	CALHM2
# MIM	612235	gene
# Organism	CAHM2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR32261	PTHR32261
# PANTHER	PTHR32261:SF3	PTHR32261:SF3
# Pfam	PF14798	Ca_hom_mod
# Proteomes	UP000005640	Chromosome 10
# RecName	CAHM2_HUMAN	Calcium homeostasis modulator protein 2
# RefSeq	NP_057000	NM_015916.4. [Q9HA72-1]
# RefSeq	XP_006717943	XM_006717880.2. [Q9HA72-1]
# RefSeq	XP_006717946	XM_006717883.2. [Q9HA72-1]
# RefSeq	XP_006717947	XM_006717884.3. [Q9HA72-3]
# RefSeq	XP_011538150	XM_011539848.2. [Q9HA72-1]
# RefSeq	XP_016871795	XM_017016306.1. [Q9HA72-1]
# RefSeq	XP_016871796	XM_017016307.1. [Q9HA72-1]
# RefSeq	XP_016871797	XM_017016308.1. [Q9HA72-3]
# RefSeq	XP_016871798	XM_017016309.1. [Q9HA72-3]
# SIMILARITY	Belongs to the FAM26 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	CAHM2_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	1.A.84.1	the calcium homeostasis modulator ca(2+) channel (calhm-c) family
# UCSC	uc001kxa	human. [Q9HA72-1]
# eggNOG	ENOG410IJ7Y	Eukaryota
# eggNOG	ENOG410XQ8H	LUCA
BLAST	swissprot:CAHM2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CAHM2_HUMAN
COXPRESdb	51063	http://coxpresdb.jp/data/gene/51063.shtml
CleanEx	HS_CALHM2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CALHM2
DOI	10.1016/j.cell.2008.05.048	http://dx.doi.org/10.1016/j.cell.2008.05.048
DOI	10.1038/nature02462	http://dx.doi.org/10.1038/nature02462
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF131810	http://www.ebi.ac.uk/ena/data/view/AF131810
EMBL	AK022195	http://www.ebi.ac.uk/ena/data/view/AK022195
EMBL	AK125276	http://www.ebi.ac.uk/ena/data/view/AK125276
EMBL	AL139339	http://www.ebi.ac.uk/ena/data/view/AL139339
EMBL	BC000039	http://www.ebi.ac.uk/ena/data/view/BC000039
EMBL	CH471066	http://www.ebi.ac.uk/ena/data/view/CH471066
EMBL	CH471066	http://www.ebi.ac.uk/ena/data/view/CH471066
EMBL	CH471066	http://www.ebi.ac.uk/ena/data/view/CH471066
EMBL	CH471066	http://www.ebi.ac.uk/ena/data/view/CH471066
EMBL	CH471066	http://www.ebi.ac.uk/ena/data/view/CH471066
Ensembl	ENST00000260743	http://www.ensembl.org/id/ENST00000260743
Ensembl	ENST00000369788	http://www.ensembl.org/id/ENST00000369788
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005261	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005261
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	CALHM2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CALHM2
GeneID	51063	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51063
GeneTree	ENSGT00530000062796	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062796
HGNC	HGNC:23493	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:23493
HOGENOM	HOG000294134	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294134&db=HOGENOM6
HOVERGEN	HBG057802	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG057802&db=HOVERGEN
HPA	HPA014706	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014706
InParanoid	Q9HA72	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9HA72
InterPro	IPR029569	http://www.ebi.ac.uk/interpro/entry/IPR029569
InterPro	IPR029570	http://www.ebi.ac.uk/interpro/entry/IPR029570
Jabion	51063	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=51063
KEGG_Gene	hsa:51063	http://www.genome.jp/dbget-bin/www_bget?hsa:51063
MIM	612235	http://www.ncbi.nlm.nih.gov/omim/612235
OMA	SAAPNFL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SAAPNFL
OrthoDB	EOG091G0BN1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0BN1
PANTHER	PTHR32261	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32261
PANTHER	PTHR32261:SF3	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32261:SF3
PSORT	swissprot:CAHM2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CAHM2_HUMAN
PSORT-B	swissprot:CAHM2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CAHM2_HUMAN
PSORT2	swissprot:CAHM2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CAHM2_HUMAN
Pfam	PF14798	http://pfam.xfam.org/family/PF14798
PharmGKB	PA162380963	http://www.pharmgkb.org/do/serve?objId=PA162380963&objCls=Gene
Phobius	swissprot:CAHM2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CAHM2_HUMAN
PhylomeDB	Q9HA72	http://phylomedb.org/?seqid=Q9HA72
ProteinModelPortal	Q9HA72	http://www.proteinmodelportal.org/query/uniprot/Q9HA72
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15164054	http://www.ncbi.nlm.nih.gov/pubmed/15164054
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18585350	http://www.ncbi.nlm.nih.gov/pubmed/18585350
RefSeq	NP_057000	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_057000
RefSeq	XP_006717943	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006717943
RefSeq	XP_006717946	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006717946
RefSeq	XP_006717947	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006717947
RefSeq	XP_011538150	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011538150
RefSeq	XP_016871795	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016871795
RefSeq	XP_016871796	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016871796
RefSeq	XP_016871797	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016871797
RefSeq	XP_016871798	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016871798
STRING	9606.ENSP00000260743	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000260743&targetmode=cogs
TCDB	1.A.84.1	http://www.tcdb.org/search/result.php?tc=1.A.84.1
UCSC	uc001kxa	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001kxa&org=rat
UniGene	Hs.241545	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.241545
UniProtKB	CAHM2_HUMAN	http://www.uniprot.org/uniprot/CAHM2_HUMAN
UniProtKB-AC	Q9HA72	http://www.uniprot.org/uniprot/Q9HA72
charge	swissprot:CAHM2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CAHM2_HUMAN
eggNOG	ENOG410IJ7Y	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IJ7Y
eggNOG	ENOG410XQ8H	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ8H
epestfind	swissprot:CAHM2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CAHM2_HUMAN
garnier	swissprot:CAHM2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CAHM2_HUMAN
helixturnhelix	swissprot:CAHM2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CAHM2_HUMAN
hmoment	swissprot:CAHM2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CAHM2_HUMAN
iep	swissprot:CAHM2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CAHM2_HUMAN
inforesidue	swissprot:CAHM2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CAHM2_HUMAN
neXtProt	NX_Q9HA72	http://www.nextprot.org/db/entry/NX_Q9HA72
octanol	swissprot:CAHM2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CAHM2_HUMAN
pepcoil	swissprot:CAHM2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CAHM2_HUMAN
pepdigest	swissprot:CAHM2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CAHM2_HUMAN
pepinfo	swissprot:CAHM2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CAHM2_HUMAN
pepnet	swissprot:CAHM2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CAHM2_HUMAN
pepstats	swissprot:CAHM2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CAHM2_HUMAN
pepwheel	swissprot:CAHM2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CAHM2_HUMAN
pepwindow	swissprot:CAHM2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CAHM2_HUMAN
sigcleave	swissprot:CAHM2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CAHM2_HUMAN
## Database	ID	URL or Descriptions
# AltName	RAMP1_HUMAN	Calcitonin-receptor-like receptor activity-modifying protein 1
# BioGrid	115558	5
# ChiTaRS	RAMP1	human
# DrugBank	DB01278	Pramlintide
# Ensembl	ENST00000254661	ENSP00000254661; ENSG00000132329
# ExpressionAtlas	O60894	baseline and differential
# FUNCTION	RAMP1_HUMAN	Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL. {ECO 0000269|PubMed 9620797}. 
# GO_component	GO:0005615	extracellular space; IEA:Ensembl.
# GO_component	GO:0005622	intracellular; IEA:GOC.
# GO_component	GO:0005886	plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0009986	cell surface; IDA:UniProtKB.
# GO_component	GO:0043235	receptor complex; IDA:UniProtKB.
# GO_function	GO:0004872	receptor activity; IDA:UniProtKB.
# GO_function	GO:0004948	calcitonin receptor activity; IDA:UniProtKB.
# GO_function	GO:0008565	protein transporter activity; IDA:UniProtKB.
# GO_function	GO:0015026	coreceptor activity; IEA:Ensembl.
# GO_function	GO:0031716	calcitonin receptor binding; IPI:UniProtKB.
# GO_process	GO:0001525	angiogenesis; IDA:UniProtKB.
# GO_process	GO:0006816	calcium ion transport; IDA:UniProtKB.
# GO_process	GO:0006886	intracellular protein transport; IEA:InterPro.
# GO_process	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway; IDA:UniProtKB.
# GO_process	GO:0015031	protein transport; IDA:UniProtKB.
# GO_process	GO:0030819	positive regulation of cAMP biosynthetic process; IDA:UniProtKB.
# GO_process	GO:0031623	receptor internalization; IDA:UniProtKB.
# GO_process	GO:0060050	positive regulation of protein glycosylation; IDA:UniProtKB.
# GO_process	GO:0072659	protein localization to plasma membrane; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005615	extracellular space
# GOslim_component	GO:0005622	intracellular
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007009	plasma membrane organization
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0048646	anatomical structure formation involved in morphogenesis
# Genevisible	O60894	HS
# HGNC	HGNC:9843	RAMP1
# InterPro	IPR006985	RAMP
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04030	 G protein-coupled receptors
# KEGG_Pathway	ko04270	Vascular smooth muscle contraction
# MIM	605153	gene
# Organism	RAMP1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR14076	PTHR14076
# PDB	2YX8	X-ray; 2.40 A; A=27-112
# PDB	3N7P	X-ray; 2.80 A; D/E/F/R=26-117
# PDB	3N7R	X-ray; 2.90 A; C/D=26-117
# PDB	3N7S	X-ray; 2.10 A; C/D=26-117
# PDB	4RWG	X-ray; 2.44 A; A/B/C=24-108
# Pfam	PF04901	RAMP
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-418555	G alpha (s) signalling events
# Reactome	R-HSA-419812	Calcitonin-like ligand receptors
# RecName	RAMP1_HUMAN	Receptor activity-modifying protein 1
# RefSeq	NP_005846	NM_005855.3
# SIMILARITY	Belongs to the RAMP family. {ECO	0000305}.
# SUBCELLULAR LOCATION	RAMP1_HUMAN	Membrane; Single-pass type I membrane protein. 
# SUBUNIT	RAMP1_HUMAN	Heterodimer of CALCRL and RAMP1. {ECO 0000269|PubMed 18725456, ECO 0000269|PubMed 20826335}. 
# TISSUE SPECIFICITY	Expressed in many tissues including the uterus, bladder, brain, pancreas and gastro-intestinal tract. {ECO:0000269|PubMed	9620797}. 
# UCSC	uc002vxj	human
# eggNOG	ENOG410IZHQ	Eukaryota
# eggNOG	ENOG4111NGJ	LUCA
BLAST	swissprot:RAMP1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:RAMP1_HUMAN
BioCyc	ZFISH:ENSG00000132329-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000132329-MONOMER
COXPRESdb	10267	http://coxpresdb.jp/data/gene/10267.shtml
CleanEx	HS_RAMP1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_RAMP1
DIP	DIP-37675N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-37675N
DOI	10.1016/j.str.2010.05.014	http://dx.doi.org/10.1016/j.str.2010.05.014
DOI	10.1038/30666	http://dx.doi.org/10.1038/30666
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1110/ps.036012.108	http://dx.doi.org/10.1110/ps.036012.108
DrugBank	DB01278	http://www.drugbank.ca/drugs/DB01278
EMBL	AJ001014	http://www.ebi.ac.uk/ena/data/view/AJ001014
EMBL	AY265457	http://www.ebi.ac.uk/ena/data/view/AY265457
EMBL	BC000548	http://www.ebi.ac.uk/ena/data/view/BC000548
EMBL	CH471063	http://www.ebi.ac.uk/ena/data/view/CH471063
EMBL	CR542032	http://www.ebi.ac.uk/ena/data/view/CR542032
EMBL	CR542044	http://www.ebi.ac.uk/ena/data/view/CR542044
Ensembl	ENST00000254661	http://www.ensembl.org/id/ENST00000254661
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005615
GO_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0043235	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043235
GO_function	GO:0004872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004872
GO_function	GO:0004948	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004948
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0015026	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015026
GO_function	GO:0031716	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031716
GO_process	GO:0001525	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001525
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0006886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006886
GO_process	GO:0008277	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008277
GO_process	GO:0015031	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031
GO_process	GO:0030819	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030819
GO_process	GO:0031623	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031623
GO_process	GO:0060050	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060050
GO_process	GO:0072659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072659
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005615
GOslim_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007009
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0048646	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048646
GeneCards	RAMP1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=RAMP1
GeneID	10267	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10267
GeneTree	ENSGT00390000016200	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000016200
HGNC	HGNC:9843	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:9843
HOGENOM	HOG000253018	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000253018&db=HOGENOM6
HOVERGEN	HBG061268	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG061268&db=HOVERGEN
HPA	HPA057814	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA057814
InParanoid	O60894	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O60894
IntAct	O60894	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O60894*
InterPro	IPR006985	http://www.ebi.ac.uk/interpro/entry/IPR006985
Jabion	10267	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10267
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04030	http://www.genome.jp/dbget-bin/www_bget?ko04030
KEGG_Gene	hsa:10267	http://www.genome.jp/dbget-bin/www_bget?hsa:10267
KEGG_Orthology	KO:K08447	http://www.genome.jp/dbget-bin/www_bget?KO:K08447
KEGG_Pathway	ko04270	http://www.genome.jp/kegg-bin/show_pathway?ko04270
MIM	605153	http://www.ncbi.nlm.nih.gov/omim/605153
OMA	WRSKRPE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WRSKRPE
OrthoDB	EOG091G0KY6	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0KY6
PANTHER	PTHR14076	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14076
PDB	2YX8	http://www.ebi.ac.uk/pdbe-srv/view/entry/2YX8
PDB	3N7P	http://www.ebi.ac.uk/pdbe-srv/view/entry/3N7P
PDB	3N7R	http://www.ebi.ac.uk/pdbe-srv/view/entry/3N7R
PDB	3N7S	http://www.ebi.ac.uk/pdbe-srv/view/entry/3N7S
PDB	4RWG	http://www.ebi.ac.uk/pdbe-srv/view/entry/4RWG
PDBsum	2YX8	http://www.ebi.ac.uk/pdbsum/2YX8
PDBsum	3N7P	http://www.ebi.ac.uk/pdbsum/3N7P
PDBsum	3N7R	http://www.ebi.ac.uk/pdbsum/3N7R
PDBsum	3N7S	http://www.ebi.ac.uk/pdbsum/3N7S
PDBsum	4RWG	http://www.ebi.ac.uk/pdbsum/4RWG
PSORT	swissprot:RAMP1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:RAMP1_HUMAN
PSORT-B	swissprot:RAMP1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:RAMP1_HUMAN
PSORT2	swissprot:RAMP1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:RAMP1_HUMAN
Pfam	PF04901	http://pfam.xfam.org/family/PF04901
PharmGKB	PA34202	http://www.pharmgkb.org/do/serve?objId=PA34202&objCls=Gene
Phobius	swissprot:RAMP1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:RAMP1_HUMAN
PhylomeDB	O60894	http://phylomedb.org/?seqid=O60894
ProteinModelPortal	O60894	http://www.proteinmodelportal.org/query/uniprot/O60894
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18725456	http://www.ncbi.nlm.nih.gov/pubmed/18725456
PubMed	20826335	http://www.ncbi.nlm.nih.gov/pubmed/20826335
PubMed	9620797	http://www.ncbi.nlm.nih.gov/pubmed/9620797
Reactome	R-HSA-418555	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418555
Reactome	R-HSA-419812	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-419812
RefSeq	NP_005846	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005846
SMR	O60894	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O60894
STRING	9606.ENSP00000254661	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000254661&targetmode=cogs
UCSC	uc002vxj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002vxj&org=rat
UniGene	Hs.471783	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.471783
UniProtKB	RAMP1_HUMAN	http://www.uniprot.org/uniprot/RAMP1_HUMAN
UniProtKB-AC	O60894	http://www.uniprot.org/uniprot/O60894
charge	swissprot:RAMP1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:RAMP1_HUMAN
eggNOG	ENOG410IZHQ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IZHQ
eggNOG	ENOG4111NGJ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111NGJ
epestfind	swissprot:RAMP1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:RAMP1_HUMAN
garnier	swissprot:RAMP1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:RAMP1_HUMAN
helixturnhelix	swissprot:RAMP1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:RAMP1_HUMAN
hmoment	swissprot:RAMP1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:RAMP1_HUMAN
iep	swissprot:RAMP1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:RAMP1_HUMAN
inforesidue	swissprot:RAMP1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:RAMP1_HUMAN
neXtProt	NX_O60894	http://www.nextprot.org/db/entry/NX_O60894
octanol	swissprot:RAMP1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:RAMP1_HUMAN
pepcoil	swissprot:RAMP1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:RAMP1_HUMAN
pepdigest	swissprot:RAMP1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:RAMP1_HUMAN
pepinfo	swissprot:RAMP1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:RAMP1_HUMAN
pepnet	swissprot:RAMP1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:RAMP1_HUMAN
pepstats	swissprot:RAMP1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:RAMP1_HUMAN
pepwheel	swissprot:RAMP1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:RAMP1_HUMAN
pepwindow	swissprot:RAMP1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:RAMP1_HUMAN
sigcleave	swissprot:RAMP1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:RAMP1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	NRAM1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P49279-1; Sequence=Displayed; Name=2; IsoId=P49279-2; Sequence=VSP_047875, VSP_047876; Note=No experimental confirmation available.; 
# AltName	NRAM1_HUMAN	Solute carrier family 11 member 1
# CCDS	CCDS2415	-. [P49279-1]
# ChiTaRS	SLC11A1	human
# Ensembl	ENST00000233202	ENSP00000233202; ENSG00000018280. [P49279-1]
# ExpressionAtlas	P49279	baseline and differential
# FUNCTION	NRAM1_HUMAN	Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes. 
# GO_component	GO:0005764	lysosome; ISS:BHF-UCL.
# GO_component	GO:0005770	late endosome; ISS:BHF-UCL.
# GO_component	GO:0005886	plasma membrane; IMP:BHF-UCL.
# GO_component	GO:0005887	integral component of plasma membrane; NAS:UniProtKB.
# GO_component	GO:0009279	cell outer membrane; IEA:Ensembl.
# GO_component	GO:0030670	phagocytic vesicle membrane; IDA:BHF-UCL.
# GO_component	GO:0031902	late endosome membrane; TAS:Reactome.
# GO_component	GO:0070821	tertiary granule membrane; IDA:BHF-UCL.
# GO_function	GO:0005384	manganese ion transmembrane transporter activity; ISS:BHF-UCL.
# GO_function	GO:0042803	protein homodimerization activity; IDA:UniProtKB.
# GO_function	GO:0046915	transition metal ion transmembrane transporter activity; IGI:BHF-UCL.
# GO_function	NRAM1_HUMAN	GO 0051139 metal ion proton antiporter activity; IGI BHF-UCL.
# GO_process	GO:0000060	protein import into nucleus, translocation; IEA:Ensembl.
# GO_process	GO:0001818	negative regulation of cytokine production; ISS:BHF-UCL.
# GO_process	GO:0001819	positive regulation of cytokine production; ISS:BHF-UCL.
# GO_process	GO:0002309	T cell proliferation involved in immune response; ISS:BHF-UCL.
# GO_process	GO:0002369	T cell cytokine production; ISS:BHF-UCL.
# GO_process	GO:0002606	positive regulation of dendritic cell antigen processing and presentation; ISS:BHF-UCL.
# GO_process	GO:0002827	positive regulation of T-helper 1 type immune response; ISS:BHF-UCL.
# GO_process	GO:0006826	iron ion transport; IMP:BHF-UCL.
# GO_process	GO:0006828	manganese ion transport; ISS:BHF-UCL.
# GO_process	GO:0006876	cellular cadmium ion homeostasis; IGI:BHF-UCL.
# GO_process	GO:0006879	cellular iron ion homeostasis; IMP:BHF-UCL.
# GO_process	GO:0006909	phagocytosis; ISS:BHF-UCL.
# GO_process	GO:0006954	inflammatory response; ISS:BHF-UCL.
# GO_process	GO:0007035	vacuolar acidification; ISS:BHF-UCL.
# GO_process	GO:0009617	response to bacterium; IDA:UniProtKB.
# GO_process	GO:0010628	positive regulation of gene expression; ISS:BHF-UCL.
# GO_process	GO:0015707	nitrite transport; ISS:BHF-UCL.
# GO_process	GO:0032147	activation of protein kinase activity; ISS:BHF-UCL.
# GO_process	GO:0032496	response to lipopolysaccharide; ISS:BHF-UCL.
# GO_process	GO:0032623	interleukin-2 production; ISS:BHF-UCL.
# GO_process	GO:0032632	interleukin-3 production; ISS:BHF-UCL.
# GO_process	GO:0032729	positive regulation of interferon-gamma production; ISS:BHF-UCL.
# GO_process	GO:0034341	response to interferon-gamma; ISS:BHF-UCL.
# GO_process	GO:0042060	wound healing; ISS:BHF-UCL.
# GO_process	GO:0042116	macrophage activation; ISS:BHF-UCL.
# GO_process	GO:0042742	defense response to bacterium; ISS:BHF-UCL.
# GO_process	GO:0042832	defense response to protozoan; ISS:BHF-UCL.
# GO_process	GO:0043091	L-arginine import; ISS:BHF-UCL.
# GO_process	GO:0045342	MHC class II biosynthetic process; ISS:BHF-UCL.
# GO_process	GO:0045454	cell redox homeostasis; TAS:Reactome.
# GO_process	GO:0045730	respiratory burst; ISS:BHF-UCL.
# GO_process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL.
# GO_process	GO:0048002	antigen processing and presentation of peptide antigen; ISS:BHF-UCL.
# GO_process	GO:0048255	mRNA stabilization; ISS:BHF-UCL.
# GO_process	GO:0050766	positive regulation of phagocytosis; ISS:BHF-UCL.
# GO_process	GO:0050829	defense response to Gram-negative bacterium; ISS:BHF-UCL.
# GO_process	GO:0055072	iron ion homeostasis; ISS:BHF-UCL.
# GO_process	GO:0060586	multicellular organismal iron ion homeostasis; ISS:BHF-UCL.
# GO_process	GO:0070574	cadmium ion transmembrane transport; IGI:BHF-UCL.
# GO_process	GO:0070839	divalent metal ion export; ISS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005764	lysosome
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007155	cell adhesion
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0008283	cell proliferation
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P49279	HS
# HAMAP	MF_00221	NRAMP
# HGNC	HGNC:10907	SLC11A1
# INDUCTION	NRAM1_HUMAN	In response to lymphokine or bacterial products. 
# InterPro	IPR001046	NRAMP_fam
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H00342	[Infectious disease] Tuberculosis
# KEGG_Pathway	ko04142	Lysosome
# KEGG_Pathway	ko04978	Mineral absorption
# MIM	600266	gene
# MIM	607948	phenotype
# MIM	610446	phenotype
# Organism	NRAM1_HUMAN	Homo sapiens (Human)
# Orphanet	3389	Tuberculosis
# PANTHER	PTHR11706	PTHR11706
# PIR	I55679	I55679
# PIR	JC4095	JC4095
# POLYMORPHISM	Genetic variation in SLC11A1 is associated with susceptibility to infection with Mycobacterium ulcerans [MIM	610446]. 
# POLYMORPHISM	Genetic variations in SLC11A1 determine Mycobacterium tuberculosis susceptibility [MIM	607948]. 
# PRINTS	PR00447	NATRESASSCMP
# Pfam	PF01566	Nramp
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-1222556	ROS, RNS production in response to bacteria
# Reactome	R-HSA-425410	Metal ion SLC transporters
# Reactome	R-HSA-6798695	Neutrophil degranulation
# Reactome	R-HSA-6803544	Ion influx/efflux at host-pathogen interface
# RecName	NRAM1_HUMAN	Natural resistance-associated macrophage protein 1
# RefSeq	NP_000569	NM_000578.3. [P49279-1]
# RefSeq	XP_005246850	XM_005246793.3
# RefSeq	XP_005246851	XM_005246794.3
# RefSeq	XP_006712772	XM_006712709.3. [P49279-2]
# RefSeq	XP_006712773	XM_006712710.3. [P49279-2]
# RefSeq	XP_016860255	XM_017004766.1
# SIMILARITY	Belongs to the NRAMP family. {ECO	0000305}.
# SUBCELLULAR LOCATION	NRAM1_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	2.A.55.2	the metal ion (mn(2+)-iron) transporter (nramp) family
# TIGRFAMs	TIGR01197	nramp
# TISSUE SPECIFICITY	NRAM1_HUMAN	Macrophages; peripheral blood leukocytes, lung, spleen and liver. 
# UCSC	uc002vhv	human. [P49279-1]
# eggNOG	COG1914	LUCA
# eggNOG	KOG1291	Eukaryota
BLAST	swissprot:NRAM1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NRAM1_HUMAN
BioCyc	ZFISH:ENSG00000018280-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000018280-MONOMER
COXPRESdb	6556	http://coxpresdb.jp/data/gene/6556.shtml
CleanEx	HS_SLC11A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC11A1
DOI	10.1006/bbrc.1994.2572	http://dx.doi.org/10.1006/bbrc.1994.2572
DOI	10.1007/s003350010151	http://dx.doi.org/10.1007/s003350010151
DOI	10.1016/0165-2478(95)00070-L	http://dx.doi.org/10.1016/0165-2478(95)00070-L
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/sj.gene.6364281	http://dx.doi.org/10.1038/sj.gene.6364281
DOI	10.1073/pnas.0503368102	http://dx.doi.org/10.1073/pnas.0503368102
DOI	10.1084/jem.180.5.1741	http://dx.doi.org/10.1084/jem.180.5.1741
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC021016	http://www.ebi.ac.uk/ena/data/view/AC021016
EMBL	AF229163	http://www.ebi.ac.uk/ena/data/view/AF229163
EMBL	BC071165	http://www.ebi.ac.uk/ena/data/view/BC071165
EMBL	CH471063	http://www.ebi.ac.uk/ena/data/view/CH471063
EMBL	D38171	http://www.ebi.ac.uk/ena/data/view/D38171
EMBL	D50402	http://www.ebi.ac.uk/ena/data/view/D50402
EMBL	D50403	http://www.ebi.ac.uk/ena/data/view/D50403
EMBL	L32185	http://www.ebi.ac.uk/ena/data/view/L32185
EMBL	L38592	http://www.ebi.ac.uk/ena/data/view/L38592
EMBL	L38593	http://www.ebi.ac.uk/ena/data/view/L38593
EMBL	X82015	http://www.ebi.ac.uk/ena/data/view/X82015
Ensembl	ENST00000233202	http://www.ensembl.org/id/ENST00000233202
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GO_component	GO:0005770	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005770
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0009279	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279
GO_component	GO:0030670	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030670
GO_component	GO:0031902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031902
GO_component	GO:0070821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070821
GO_function	GO:0005384	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005384
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_function	GO:0046915	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046915
GO_function	GO:0051139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051139
GO_process	GO:0000060	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000060
GO_process	GO:0001818	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001818
GO_process	GO:0001819	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001819
GO_process	GO:0002309	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002309
GO_process	GO:0002369	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002369
GO_process	GO:0002606	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002606
GO_process	GO:0002827	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002827
GO_process	GO:0006826	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006826
GO_process	GO:0006828	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006828
GO_process	GO:0006876	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006876
GO_process	GO:0006879	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006879
GO_process	GO:0006909	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006909
GO_process	GO:0006954	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006954
GO_process	GO:0007035	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007035
GO_process	GO:0009617	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009617
GO_process	GO:0010628	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010628
GO_process	GO:0015707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015707
GO_process	GO:0032147	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032147
GO_process	GO:0032496	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032496
GO_process	GO:0032623	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032623
GO_process	GO:0032632	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032632
GO_process	GO:0032729	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032729
GO_process	GO:0034341	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034341
GO_process	GO:0042060	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042060
GO_process	GO:0042116	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042116
GO_process	GO:0042742	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042742
GO_process	GO:0042832	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042832
GO_process	GO:0043091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043091
GO_process	GO:0045342	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045342
GO_process	GO:0045454	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045454
GO_process	GO:0045730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045730
GO_process	GO:0045944	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045944
GO_process	GO:0048002	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048002
GO_process	GO:0048255	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048255
GO_process	GO:0050766	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050766
GO_process	GO:0050829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050829
GO_process	GO:0055072	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072
GO_process	GO:0060586	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060586
GO_process	GO:0070574	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070574
GO_process	GO:0070839	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070839
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0008283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008283
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC11A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC11A1
GeneID	6556	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6556
GeneTree	ENSGT00390000006526	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000006526
HAMAP	MF_00221	http://hamap.expasy.org/unirule/MF_00221
HGNC	HGNC:10907	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10907
HOGENOM	HOG000152203	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000152203&db=HOGENOM6
HOVERGEN	HBG052665	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052665&db=HOVERGEN
HPA	HPA029590	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA029590
InParanoid	P49279	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P49279
InterPro	IPR001046	http://www.ebi.ac.uk/interpro/entry/IPR001046
Jabion	6556	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6556
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00342	http://www.genome.jp/dbget-bin/www_bget?H00342
KEGG_Gene	hsa:6556	http://www.genome.jp/dbget-bin/www_bget?hsa:6556
KEGG_Orthology	KO:K12347	http://www.genome.jp/dbget-bin/www_bget?KO:K12347
KEGG_Pathway	ko04142	http://www.genome.jp/kegg-bin/show_pathway?ko04142
KEGG_Pathway	ko04978	http://www.genome.jp/kegg-bin/show_pathway?ko04978
MIM	600266	http://www.ncbi.nlm.nih.gov/omim/600266
MIM	607948	http://www.ncbi.nlm.nih.gov/omim/607948
MIM	610446	http://www.ncbi.nlm.nih.gov/omim/610446
OMA	HQRFLYG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HQRFLYG
Orphanet	3389	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=3389
OrthoDB	EOG091G05M9	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05M9
PANTHER	PTHR11706	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11706
PRINTS	PR00447	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00447
PSORT	swissprot:NRAM1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NRAM1_HUMAN
PSORT-B	swissprot:NRAM1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NRAM1_HUMAN
PSORT2	swissprot:NRAM1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NRAM1_HUMAN
Pfam	PF01566	http://pfam.xfam.org/family/PF01566
PharmGKB	PA319	http://www.pharmgkb.org/do/serve?objId=PA319&objCls=Gene
Phobius	swissprot:NRAM1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NRAM1_HUMAN
PhylomeDB	P49279	http://phylomedb.org/?seqid=P49279
ProteinModelPortal	P49279	http://www.proteinmodelportal.org/query/uniprot/P49279
PubMed	10967134	http://www.ncbi.nlm.nih.gov/pubmed/10967134
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	16103355	http://www.ncbi.nlm.nih.gov/pubmed/16103355
PubMed	16395392	http://www.ncbi.nlm.nih.gov/pubmed/16395392
PubMed	7717395	http://www.ncbi.nlm.nih.gov/pubmed/7717395
PubMed	7964458	http://www.ncbi.nlm.nih.gov/pubmed/7964458
PubMed	7980580	http://www.ncbi.nlm.nih.gov/pubmed/7980580
PubMed	8529098	http://www.ncbi.nlm.nih.gov/pubmed/8529098
PubMed	8537108	http://www.ncbi.nlm.nih.gov/pubmed/8537108
Reactome	R-HSA-1222556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1222556
Reactome	R-HSA-425410	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425410
Reactome	R-HSA-6798695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6798695
Reactome	R-HSA-6803544	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6803544
RefSeq	NP_000569	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000569
RefSeq	XP_005246850	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005246850
RefSeq	XP_005246851	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005246851
RefSeq	XP_006712772	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006712772
RefSeq	XP_006712773	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006712773
RefSeq	XP_016860255	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016860255
STRING	9606.ENSP00000233202	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000233202&targetmode=cogs
TCDB	2.A.55.2	http://www.tcdb.org/search/result.php?tc=2.A.55.2
TIGRFAMs	TIGR01197	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01197
UCSC	uc002vhv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002vhv&org=rat
UniGene	Hs.591607	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.591607
UniProtKB	NRAM1_HUMAN	http://www.uniprot.org/uniprot/NRAM1_HUMAN
UniProtKB-AC	P49279	http://www.uniprot.org/uniprot/P49279
charge	swissprot:NRAM1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NRAM1_HUMAN
eggNOG	COG1914	http://eggnogapi.embl.de/nog_data/html/tree/COG1914
eggNOG	KOG1291	http://eggnogapi.embl.de/nog_data/html/tree/KOG1291
epestfind	swissprot:NRAM1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NRAM1_HUMAN
garnier	swissprot:NRAM1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NRAM1_HUMAN
helixturnhelix	swissprot:NRAM1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NRAM1_HUMAN
hmoment	swissprot:NRAM1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NRAM1_HUMAN
iep	swissprot:NRAM1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NRAM1_HUMAN
inforesidue	swissprot:NRAM1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NRAM1_HUMAN
neXtProt	NX_P49279	http://www.nextprot.org/db/entry/NX_P49279
octanol	swissprot:NRAM1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NRAM1_HUMAN
pepcoil	swissprot:NRAM1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NRAM1_HUMAN
pepdigest	swissprot:NRAM1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NRAM1_HUMAN
pepinfo	swissprot:NRAM1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NRAM1_HUMAN
pepnet	swissprot:NRAM1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NRAM1_HUMAN
pepstats	swissprot:NRAM1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NRAM1_HUMAN
pepwheel	swissprot:NRAM1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NRAM1_HUMAN
pepwindow	swissprot:NRAM1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NRAM1_HUMAN
sigcleave	swissprot:NRAM1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NRAM1_HUMAN
## Database	ID	URL or Descriptions
# AltName	P2RX3_HUMAN	ATP receptor
# AltName	P2RX3_HUMAN	Purinergic receptor
# ChiTaRS	P2RX3	human
# Ensembl	ENST00000263314	ENSP00000263314; ENSG00000109991
# ExpressionAtlas	P56373	baseline and differential
# FUNCTION	P2RX3_HUMAN	Receptor for ATP that acts as a ligand-gated ion channel. 
# GO_component	GO:0005639	integral component of nuclear inner membrane; IBA:GO_Central.
# GO_component	GO:0005791	rough endoplasmic reticulum; IEA:Ensembl.
# GO_component	GO:0005794	Golgi apparatus; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0043025	neuronal cell body; IEA:Ensembl.
# GO_component	GO:0043195	terminal bouton; IEA:Ensembl.
# GO_component	GO:0043197	dendritic spine; IEA:Ensembl.
# GO_component	GO:0043235	receptor complex; IDA:MGI.
# GO_component	GO:0045121	membrane raft; IEA:Ensembl.
# GO_function	GO:0001614	purinergic nucleotide receptor activity; NAS:BHF-UCL.
# GO_function	GO:0004931	extracellular ATP-gated cation channel activity; NAS:BHF-UCL.
# GO_function	GO:0005524	ATP binding; NAS:BHF-UCL.
# GO_process	GO:0001666	response to hypoxia; IEA:Ensembl.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0007274	neuromuscular synaptic transmission; IEA:Ensembl.
# GO_process	GO:0007596	blood coagulation; TAS:Reactome.
# GO_process	GO:0009408	response to heat; IEA:Ensembl.
# GO_process	GO:0009409	response to cold; IEA:Ensembl.
# GO_process	GO:0009612	response to mechanical stimulus; IEA:Ensembl.
# GO_process	GO:0009743	response to carbohydrate; IEA:Ensembl.
# GO_process	GO:0010524	positive regulation of calcium ion transport into cytosol; NAS:BHF-UCL.
# GO_process	GO:0014832	urinary bladder smooth muscle contraction; IEA:Ensembl.
# GO_process	GO:0019228	neuronal action potential; IEA:Ensembl.
# GO_process	GO:0030432	peristalsis; IEA:Ensembl.
# GO_process	GO:0033198	response to ATP; IEA:Ensembl.
# GO_process	GO:0048167	regulation of synaptic plasticity; IEA:Ensembl.
# GO_process	GO:0050850	positive regulation of calcium-mediated signaling; NAS:BHF-UCL.
# GO_process	GO:0050909	sensory perception of taste; IEA:Ensembl.
# GO_process	GO:0051260	protein homooligomerization; IEA:Ensembl.
# GO_process	GO:0061368	behavioral response to formalin induced pain; IEA:Ensembl.
# GO_process	GO:1904058	positive regulation of sensory perception of pain; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# Gene3D	2.60.490.10	-; 1.
# Genevisible	P56373	HS
# HGNC	HGNC:8534	P2RX3
# InterPro	IPR001429	P2X_purnocptor
# InterPro	IPR003046	P2X3_purnocptor
# InterPro	IPR027309	P2X_extracellular_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# MIM	600843	gene
# Organism	P2RX3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10125	PTHR10125
# PANTHER	PTHR10125:SF8	PTHR10125:SF8
# PDB	5SVJ	X-ray; 2.98 A; A=6-364
# PDB	5SVK	X-ray; 2.77 A; A/B=6-364
# PDB	5SVL	X-ray; 2.90 A; A/B=6-364
# PDB	5SVM	X-ray; 3.09 A; A/B=6-364
# PDB	5SVP	X-ray; 3.30 A; A/B=6-364
# PDB	5SVQ	X-ray; 3.25 A; A=6-364
# PDB	5SVR	X-ray; 3.13 A; A=6-364
# PDB	5SVS	X-ray; 4.03 A; A=6-364
# PDB	5SVT	X-ray; 3.79 A; A=6-364
# PIRSF	PIRSF005713	P2X_purinoceptor
# PRINTS	PR01307	P2XRECEPTOR
# PRINTS	PR01310	P2X3RECEPTOR
# PROSITE	PS01212	P2X_RECEPTOR
# Pfam	PF00864	P2X_receptor
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-139853	Elevation of cytosolic Ca2+ levels
# Reactome	R-HSA-418346	Platelet homeostasis
# RecName	P2RX3_HUMAN	P2X purinoceptor 3
# RefSeq	NP_002550	NM_002559.3
# RefSeq	XP_011543371	XM_011545069.2
# RefSeq	XP_011543372	XM_011545070.2
# SIMILARITY	Belongs to the P2X receptor family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	P2RX3_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Functional P2XRs are organized as homomeric and heteromeric trimers. {ECO	0000250}. 
# TCDB	1.A.7.1	the atp-gated p2x receptor cation channel (p2x receptor) family
# TIGRFAMs	TIGR00863	P2X
# UCSC	uc001nju	human
# WEB RESOURCE	P2RX3_HUMAN	Name=Wikipedia; Note=P2X receptor entry; URL="https //en.wikipedia.org/wiki/P2X_receptor";
# eggNOG	ENOG410IFJF	Eukaryota
# eggNOG	ENOG410XR0C	LUCA
BLAST	swissprot:P2RX3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:P2RX3_HUMAN
BioCyc	ZFISH:ENSG00000109991-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000109991-MONOMER
COXPRESdb	5024	http://coxpresdb.jp/data/gene/5024.shtml
CleanEx	HS_P2RX3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_P2RX3
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB016608	http://www.ebi.ac.uk/ena/data/view/AB016608
EMBL	AP000781	http://www.ebi.ac.uk/ena/data/view/AP000781
EMBL	BC074792	http://www.ebi.ac.uk/ena/data/view/BC074792
EMBL	BC074793	http://www.ebi.ac.uk/ena/data/view/BC074793
EMBL	BC109287	http://www.ebi.ac.uk/ena/data/view/BC109287
EMBL	Y07683	http://www.ebi.ac.uk/ena/data/view/Y07683
Ensembl	ENST00000263314	http://www.ensembl.org/id/ENST00000263314
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005639	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005639
GO_component	GO:0005791	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005791
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0043195	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043195
GO_component	GO:0043197	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043197
GO_component	GO:0043235	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043235
GO_component	GO:0045121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045121
GO_function	GO:0001614	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001614
GO_function	GO:0004931	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004931
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_process	GO:0001666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001666
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007274	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007274
GO_process	GO:0007596	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007596
GO_process	GO:0009408	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408
GO_process	GO:0009409	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009409
GO_process	GO:0009612	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009612
GO_process	GO:0009743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009743
GO_process	GO:0010524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010524
GO_process	GO:0014832	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014832
GO_process	GO:0019228	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019228
GO_process	GO:0030432	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030432
GO_process	GO:0033198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033198
GO_process	GO:0048167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048167
GO_process	GO:0050850	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050850
GO_process	GO:0050909	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050909
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:0061368	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061368
GO_process	GO:1904058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1904058
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
Gene3D	2.60.490.10	http://www.cathdb.info/version/latest/superfamily/2.60.490.10
GeneCards	P2RX3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=P2RX3
GeneID	5024	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5024
GeneTree	ENSGT00390000016028	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000016028
H-InvDB	HIX0035814	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0035814
HGNC	HGNC:8534	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:8534
HOGENOM	HOG000232042	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000232042&db=HOGENOM6
HOVERGEN	HBG053086	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053086&db=HOVERGEN
HPA	HPA057776	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA057776
InParanoid	P56373	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P56373
InterPro	IPR001429	http://www.ebi.ac.uk/interpro/entry/IPR001429
InterPro	IPR003046	http://www.ebi.ac.uk/interpro/entry/IPR003046
InterPro	IPR027309	http://www.ebi.ac.uk/interpro/entry/IPR027309
Jabion	5024	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=5024
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:5024	http://www.genome.jp/dbget-bin/www_bget?hsa:5024
KEGG_Orthology	KO:K05217	http://www.genome.jp/dbget-bin/www_bget?KO:K05217
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
MIM	600843	http://www.ncbi.nlm.nih.gov/omim/600843
OMA	VLRTCEI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VLRTCEI
OrthoDB	EOG091G0A2U	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0A2U
PANTHER	PTHR10125	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10125
PANTHER	PTHR10125:SF8	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10125:SF8
PDB	5SVJ	http://www.ebi.ac.uk/pdbe-srv/view/entry/5SVJ
PDB	5SVK	http://www.ebi.ac.uk/pdbe-srv/view/entry/5SVK
PDB	5SVL	http://www.ebi.ac.uk/pdbe-srv/view/entry/5SVL
PDB	5SVM	http://www.ebi.ac.uk/pdbe-srv/view/entry/5SVM
PDB	5SVP	http://www.ebi.ac.uk/pdbe-srv/view/entry/5SVP
PDB	5SVQ	http://www.ebi.ac.uk/pdbe-srv/view/entry/5SVQ
PDB	5SVR	http://www.ebi.ac.uk/pdbe-srv/view/entry/5SVR
PDB	5SVS	http://www.ebi.ac.uk/pdbe-srv/view/entry/5SVS
PDB	5SVT	http://www.ebi.ac.uk/pdbe-srv/view/entry/5SVT
PDBsum	5SVJ	http://www.ebi.ac.uk/pdbsum/5SVJ
PDBsum	5SVK	http://www.ebi.ac.uk/pdbsum/5SVK
PDBsum	5SVL	http://www.ebi.ac.uk/pdbsum/5SVL
PDBsum	5SVM	http://www.ebi.ac.uk/pdbsum/5SVM
PDBsum	5SVP	http://www.ebi.ac.uk/pdbsum/5SVP
PDBsum	5SVQ	http://www.ebi.ac.uk/pdbsum/5SVQ
PDBsum	5SVR	http://www.ebi.ac.uk/pdbsum/5SVR
PDBsum	5SVS	http://www.ebi.ac.uk/pdbsum/5SVS
PDBsum	5SVT	http://www.ebi.ac.uk/pdbsum/5SVT
PRINTS	PR01307	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01307
PRINTS	PR01310	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01310
PROSITE	PS01212	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01212
PSORT	swissprot:P2RX3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:P2RX3_HUMAN
PSORT-B	swissprot:P2RX3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:P2RX3_HUMAN
PSORT2	swissprot:P2RX3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:P2RX3_HUMAN
Pfam	PF00864	http://pfam.xfam.org/family/PF00864
PharmGKB	PA32863	http://www.pharmgkb.org/do/serve?objId=PA32863&objCls=Gene
Phobius	swissprot:P2RX3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:P2RX3_HUMAN
PhylomeDB	P56373	http://phylomedb.org/?seqid=P56373
ProteinModelPortal	P56373	http://www.proteinmodelportal.org/query/uniprot/P56373
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	9016352	http://www.ncbi.nlm.nih.gov/pubmed/9016352
Reactome	R-HSA-139853	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-139853
Reactome	R-HSA-418346	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418346
RefSeq	NP_002550	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002550
RefSeq	XP_011543371	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011543371
RefSeq	XP_011543372	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011543372
SMR	P56373	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P56373
STRING	9606.ENSP00000263314	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000263314&targetmode=cogs
TCDB	1.A.7.1	http://www.tcdb.org/search/result.php?tc=1.A.7.1
TIGRFAMs	TIGR00863	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00863
UCSC	uc001nju	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001nju&org=rat
UniGene	Hs.146738	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.146738
UniProtKB	P2RX3_HUMAN	http://www.uniprot.org/uniprot/P2RX3_HUMAN
UniProtKB-AC	P56373	http://www.uniprot.org/uniprot/P56373
charge	swissprot:P2RX3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:P2RX3_HUMAN
eggNOG	ENOG410IFJF	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IFJF
eggNOG	ENOG410XR0C	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XR0C
epestfind	swissprot:P2RX3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:P2RX3_HUMAN
garnier	swissprot:P2RX3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:P2RX3_HUMAN
helixturnhelix	swissprot:P2RX3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:P2RX3_HUMAN
hmoment	swissprot:P2RX3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:P2RX3_HUMAN
iep	swissprot:P2RX3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:P2RX3_HUMAN
inforesidue	swissprot:P2RX3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:P2RX3_HUMAN
neXtProt	NX_P56373	http://www.nextprot.org/db/entry/NX_P56373
octanol	swissprot:P2RX3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:P2RX3_HUMAN
pepcoil	swissprot:P2RX3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:P2RX3_HUMAN
pepdigest	swissprot:P2RX3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:P2RX3_HUMAN
pepinfo	swissprot:P2RX3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:P2RX3_HUMAN
pepnet	swissprot:P2RX3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:P2RX3_HUMAN
pepstats	swissprot:P2RX3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:P2RX3_HUMAN
pepwheel	swissprot:P2RX3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:P2RX3_HUMAN
pepwindow	swissprot:P2RX3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:P2RX3_HUMAN
sigcleave	swissprot:P2RX3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:P2RX3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	VA0E2_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8NHE4-1; Sequence=Displayed; Name=2; IsoId=Q8NHE4-2; Sequence=VSP_027104; Name=3; IsoId=Q8NHE4-3; Sequence=VSP_027105; Note=May be due to a competing donor splice site.; Name=4; IsoId=Q8NHE4-4; Sequence=VSP_044857; Note=No experimental confirmation available.; 
# AltName	VA0E2_HUMAN	Lysosomal 9 kDa H(+)-transporting ATPase V0 subunit e2
# AltName	VA0E2_HUMAN	Vacuolar proton pump subunit e 2
# CCDS	CCDS55181	-. [Q8NHE4-4]
# ChiTaRS	ATP6V0E2	human
# Ensembl	ENST00000425642	ENSP00000396148; ENSG00000171130. [Q8NHE4-1]
# Ensembl	ENST00000456496	ENSP00000410220; ENSG00000171130. [Q8NHE4-4]
# Ensembl	ENST00000464662	ENSP00000475645; ENSG00000171130. [Q8NHE4-1]
# Ensembl	ENST00000471877	ENSP00000420679; ENSG00000171130. [Q8NHE4-1]
# Ensembl	ENST00000479613	ENSP00000417939; ENSG00000171130. [Q8NHE4-3]
# Ensembl	ENST00000606024	ENSP00000475904; ENSG00000171130. [Q8NHE4-2]
# Ensembl	ENST00000615196	ENSP00000481176; ENSG00000171130. [Q8NHE4-4]
# ExpressionAtlas	Q8NHE4	baseline and differential
# FUNCTION	VA0E2_HUMAN	Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. {ECO 0000250}. 
# GO_component	GO:0010008	endosome membrane; TAS:Reactome.
# GO_component	GO:0016020	membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0030670	phagocytic vesicle membrane; TAS:Reactome.
# GO_component	GO:0033179	proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
# GO_function	GO:0042625	ATPase coupled ion transmembrane transporter activity; ISS:UniProtKB.
# GO_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
# GO_process	GO:0007035	vacuolar acidification; ISS:UniProtKB.
# GO_process	GO:0008286	insulin receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0015991	ATP hydrolysis coupled proton transport; IEA:InterPro.
# GO_process	GO:0016049	cell growth; IGI:UniProtKB.
# GO_process	GO:0016241	regulation of macroautophagy; NAS:ParkinsonsUK-UCL.
# GO_process	GO:0033572	transferrin transport; TAS:Reactome.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0090383	phagosome acidification; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0040007	growth
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q8NHE4	HS
# HGNC	HGNC:21723	ATP6V0E2
# InterPro	IPR008389	ATPase_V0-cplx_e1/e2_su
# InterPro	IPR017385	ATPase_V0-cplx_e1/e2_su_met
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04966	Collecting duct acid secretion
# KEGG_Pathway	ko05110	Vibrio cholerae infection
# KEGG_Pathway	ko05120	Epithelial cell signaling in Helicobacter pylori infection
# KEGG_Pathway	ko05323	Rheumatoid arthritis
# MIM	611019	gene
# Organism	VA0E2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12263	PTHR12263
# PIRSF	PIRSF038097	V-ATP_synth_e1/e2
# Pfam	PF05493	ATP_synt_H
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-1222556	ROS, RNS production in response to bacteria
# Reactome	R-HSA-77387	Insulin receptor recycling
# Reactome	R-HSA-917977	Transferrin endocytosis and recycling
# Reactome	R-HSA-983712	Ion channel transport
# RecName	VA0E2_HUMAN	V-type proton ATPase subunit e 2
# RefSeq	NP_001094062	NM_001100592.2
# RefSeq	NP_001276919	NM_001289990.1
# RefSeq	NP_660265	NM_145230.3. [Q8NHE4-4]
# SEQUENCE CAUTION	VA0E2_HUMAN	Sequence=AAP97693.1; Type=Frameshift; Positions=80, 108; Evidence={ECO 0000305}; Sequence=AAQ96859.1; Type=Erroneous gene model prediction; Evidence={ECO 0000305}; Sequence=BAC05292.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=CAE45916.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305};
# SIMILARITY	Belongs to the V-ATPase e1/e2 subunit family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	VA0E2_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUBUNIT	VA0E2_HUMAN	Composed of at least 10 subunits. 
# TISSUE SPECIFICITY	Isoform 1 is expressed at high levels in heart, brain and kidney and also detected in inner ear epithelium, vestibule, testis, epididymis and bladder. Isoform 2 is expressed in heart, kidney, placenta and pancreas. Isoform 2 is not detected in frontal cortex, but is prevalent in all other brain areas. {ECO:0000269|PubMed	17350184}. 
# UCSC	uc003wgp	human. [Q8NHE4-1]
BLAST	swissprot:VA0E2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VA0E2_HUMAN
BioCyc	MetaCyc:HS15951-MONOMER	http://biocyc.org/getid?id=MetaCyc:HS15951-MONOMER
BioCyc	ZFISH:HS15951-MONOMER	http://biocyc.org/getid?id=ZFISH:HS15951-MONOMER
COXPRESdb	155066	http://coxpresdb.jp/data/gene/155066.shtml
CleanEx	HS_ATP6V0E2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP6V0E2
DOI	10.1016/j.gene.2007.01.020	http://dx.doi.org/10.1016/j.gene.2007.01.020
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AC093458	http://www.ebi.ac.uk/ena/data/view/AC093458
EMBL	AF452639	http://www.ebi.ac.uk/ena/data/view/AF452639
EMBL	AK098362	http://www.ebi.ac.uk/ena/data/view/AK098362
EMBL	AY037164	http://www.ebi.ac.uk/ena/data/view/AY037164
EMBL	BX640846	http://www.ebi.ac.uk/ena/data/view/BX640846
EMBL	DQ989009	http://www.ebi.ac.uk/ena/data/view/DQ989009
EMBL	DQ995344	http://www.ebi.ac.uk/ena/data/view/DQ995344
Ensembl	ENST00000425642	http://www.ensembl.org/id/ENST00000425642
Ensembl	ENST00000456496	http://www.ensembl.org/id/ENST00000456496
Ensembl	ENST00000464662	http://www.ensembl.org/id/ENST00000464662
Ensembl	ENST00000471877	http://www.ensembl.org/id/ENST00000471877
Ensembl	ENST00000479613	http://www.ensembl.org/id/ENST00000479613
Ensembl	ENST00000606024	http://www.ensembl.org/id/ENST00000606024
Ensembl	ENST00000615196	http://www.ensembl.org/id/ENST00000615196
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0010008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010008
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030670	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030670
GO_component	GO:0033179	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033179
GO_function	GO:0042625	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042625
GO_function	GO:0046961	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046961
GO_process	GO:0007035	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007035
GO_process	GO:0008286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008286
GO_process	GO:0015991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015991
GO_process	GO:0016049	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016049
GO_process	GO:0016241	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016241
GO_process	GO:0033572	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033572
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0090383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090383
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0040007	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040007
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ATP6V0E2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP6V0E2
GeneID	155066	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=155066
GeneTree	ENSGT00390000000728	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000000728
H-InvDB	HIX0007198	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0007198
HGNC	HGNC:21723	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:21723
HOGENOM	HOG000205467	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000205467&db=HOGENOM6
HOVERGEN	HBG003974	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003974&db=HOVERGEN
InParanoid	Q8NHE4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8NHE4
InterPro	IPR008389	http://www.ebi.ac.uk/interpro/entry/IPR008389
InterPro	IPR017385	http://www.ebi.ac.uk/interpro/entry/IPR017385
Jabion	155066	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=155066
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:155066	http://www.genome.jp/dbget-bin/www_bget?hsa:155066
KEGG_Orthology	KO:K02153	http://www.genome.jp/dbget-bin/www_bget?KO:K02153
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04966	http://www.genome.jp/kegg-bin/show_pathway?ko04966
KEGG_Pathway	ko05110	http://www.genome.jp/kegg-bin/show_pathway?ko05110
KEGG_Pathway	ko05120	http://www.genome.jp/kegg-bin/show_pathway?ko05120
KEGG_Pathway	ko05323	http://www.genome.jp/kegg-bin/show_pathway?ko05323
MIM	611019	http://www.ncbi.nlm.nih.gov/omim/611019
OMA	APWFVPK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=APWFVPK
PANTHER	PTHR12263	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12263
PSORT	swissprot:VA0E2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VA0E2_HUMAN
PSORT-B	swissprot:VA0E2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VA0E2_HUMAN
PSORT2	swissprot:VA0E2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VA0E2_HUMAN
Pfam	PF05493	http://pfam.xfam.org/family/PF05493
PharmGKB	PA162377277	http://www.pharmgkb.org/do/serve?objId=PA162377277&objCls=Gene
Phobius	swissprot:VA0E2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VA0E2_HUMAN
PhylomeDB	Q8NHE4	http://phylomedb.org/?seqid=Q8NHE4
ProteinModelPortal	Q8NHE4	http://www.proteinmodelportal.org/query/uniprot/Q8NHE4
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	17350184	http://www.ncbi.nlm.nih.gov/pubmed/17350184
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
Reactome	R-HSA-1222556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1222556
Reactome	R-HSA-77387	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-77387
Reactome	R-HSA-917977	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917977
Reactome	R-HSA-983712	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983712
RefSeq	NP_001094062	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001094062
RefSeq	NP_001276919	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001276919
RefSeq	NP_660265	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_660265
UCSC	uc003wgp	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003wgp&org=rat
UniGene	Hs.556998	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.556998
UniProtKB	VA0E2_HUMAN	http://www.uniprot.org/uniprot/VA0E2_HUMAN
UniProtKB-AC	Q8NHE4	http://www.uniprot.org/uniprot/Q8NHE4
charge	swissprot:VA0E2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VA0E2_HUMAN
epestfind	swissprot:VA0E2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VA0E2_HUMAN
garnier	swissprot:VA0E2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VA0E2_HUMAN
helixturnhelix	swissprot:VA0E2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VA0E2_HUMAN
hmoment	swissprot:VA0E2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VA0E2_HUMAN
iep	swissprot:VA0E2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VA0E2_HUMAN
inforesidue	swissprot:VA0E2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VA0E2_HUMAN
neXtProt	NX_Q8NHE4	http://www.nextprot.org/db/entry/NX_Q8NHE4
octanol	swissprot:VA0E2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VA0E2_HUMAN
pepcoil	swissprot:VA0E2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VA0E2_HUMAN
pepdigest	swissprot:VA0E2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VA0E2_HUMAN
pepinfo	swissprot:VA0E2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VA0E2_HUMAN
pepnet	swissprot:VA0E2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VA0E2_HUMAN
pepstats	swissprot:VA0E2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VA0E2_HUMAN
pepwheel	swissprot:VA0E2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VA0E2_HUMAN
pepwindow	swissprot:VA0E2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VA0E2_HUMAN
sigcleave	swissprot:VA0E2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VA0E2_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNJ9_HUMAN	Inward rectifier K(+) channel Kir3.3
# AltName	KCNJ9_HUMAN	Potassium channel, inwardly rectifying subfamily J member 9
# BioGrid	109967	2
# DOMAIN	KCNJ9_HUMAN	The PDZ-binding motif specifically binds the PDZ domain of SNX27  the specificity for SNX27 is provided by the 2 residues located upstream (Glu-388 and Ser-389) of the PDZ-binding motif. {ECO 0000250}. 
# DrugBank	DB00898	Ethanol
# Ensembl	ENST00000368088	ENSP00000357067; ENSG00000162728
# FUNCTION	KCNJ9_HUMAN	This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (By similarity). {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0005242	inward rectifier potassium channel activity; IBA:GO_Central.
# GO_function	GO:0015467	G-protein activated inward rectifier potassium channel activity; TAS:Reactome.
# GO_process	GO:0010107	potassium ion import; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.40.1400	-; 1.
# Genevisible	Q92806	HS
# HGNC	HGNC:6270	KCNJ9
# InterPro	IPR003276	K_chnl_inward-rec_Kir3.3
# InterPro	IPR013518	K_chnl_inward-rec_Kir_cyto
# InterPro	IPR014756	Ig_E-set
# InterPro	IPR016449	K_chnl_inward-rec_Kir
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04713	Circadian entrainment
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04726	Serotonergic synapse
# KEGG_Pathway	ko04728	Dopaminergic synapse
# KEGG_Pathway	ko05032	Morphine addiction
# MIM	600932	gene
# Organism	KCNJ9_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11767	PTHR11767
# PANTHER	PTHR11767:SF17	PTHR11767:SF17
# PIRSF	PIRSF005465	GIRK_kir
# PRINTS	PR01320	KIRCHANNEL
# PRINTS	PR01329	KIR33CHANNEL
# Pfam	PF01007	IRK
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-1296041	Activation of G protein gated Potassium channels
# Reactome	R-HSA-997272	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
# RecName	KCNJ9_HUMAN	G protein-activated inward rectifier potassium channel 3
# RefSeq	NP_004974	NM_004983.2
# SIMILARITY	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ9 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCNJ9_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Associates with GIRK1 to form a G-protein-activated heteromultimer pore-forming unit. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane (By similarity). {ECO	0000250}. 
# SUPFAM	SSF81296	SSF81296
# UCSC	uc001fuy	human
# eggNOG	ENOG410XQ62	LUCA
# eggNOG	KOG3827	Eukaryota
BLAST	swissprot:KCNJ9_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNJ9_HUMAN
BioCyc	ZFISH:ENSG00000162728-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000162728-MONOMER
COXPRESdb	3765	http://coxpresdb.jp/data/gene/3765.shtml
CleanEx	HS_KCNJ9	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNJ9
DOI	10.1006/bbrc.2000.3136	http://dx.doi.org/10.1006/bbrc.2000.3136
DOI	10.1016/S0898-6568(99)00059-5	http://dx.doi.org/10.1016/S0898-6568(99)00059-5
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
EMBL	AF193615	http://www.ebi.ac.uk/ena/data/view/AF193615
EMBL	AL121987	http://www.ebi.ac.uk/ena/data/view/AL121987
EMBL	U52152	http://www.ebi.ac.uk/ena/data/view/U52152
Ensembl	ENST00000368088	http://www.ensembl.org/id/ENST00000368088
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005242	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005242
GO_function	GO:0015467	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015467
GO_process	GO:0010107	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010107
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.40.1400	http://www.cathdb.info/version/latest/superfamily/2.60.40.1400
GeneCards	KCNJ9	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNJ9
GeneID	3765	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3765
GeneTree	ENSGT00760000118842	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118842
H-InvDB	HIX0028866	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0028866
HGNC	HGNC:6270	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6270
HOGENOM	HOG000237325	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237325&db=HOGENOM6
HOVERGEN	HBG006178	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006178&db=HOVERGEN
InParanoid	Q92806	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q92806
InterPro	IPR003276	http://www.ebi.ac.uk/interpro/entry/IPR003276
InterPro	IPR013518	http://www.ebi.ac.uk/interpro/entry/IPR013518
InterPro	IPR014756	http://www.ebi.ac.uk/interpro/entry/IPR014756
InterPro	IPR016449	http://www.ebi.ac.uk/interpro/entry/IPR016449
Jabion	3765	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3765
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3765	http://www.genome.jp/dbget-bin/www_bget?hsa:3765
KEGG_Orthology	KO:K05002	http://www.genome.jp/dbget-bin/www_bget?KO:K05002
KEGG_Pathway	ko04713	http://www.genome.jp/kegg-bin/show_pathway?ko04713
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04726	http://www.genome.jp/kegg-bin/show_pathway?ko04726
KEGG_Pathway	ko04728	http://www.genome.jp/kegg-bin/show_pathway?ko04728
KEGG_Pathway	ko05032	http://www.genome.jp/kegg-bin/show_pathway?ko05032
MIM	600932	http://www.ncbi.nlm.nih.gov/omim/600932
OMA	HLYWSIS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HLYWSIS
OrthoDB	EOG091G08HC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08HC
PANTHER	PTHR11767	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11767
PANTHER	PTHR11767:SF17	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11767:SF17
PRINTS	PR01320	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01320
PRINTS	PR01329	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01329
PSORT	swissprot:KCNJ9_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNJ9_HUMAN
PSORT-B	swissprot:KCNJ9_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNJ9_HUMAN
PSORT2	swissprot:KCNJ9_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNJ9_HUMAN
Pfam	PF01007	http://pfam.xfam.org/family/PF01007
PharmGKB	PA30051	http://www.pharmgkb.org/do/serve?objId=PA30051&objCls=Gene
Phobius	swissprot:KCNJ9_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNJ9_HUMAN
PhylomeDB	Q92806	http://phylomedb.org/?seqid=Q92806
ProteinModelPortal	Q92806	http://www.proteinmodelportal.org/query/uniprot/Q92806
PubMed	10659995	http://www.ncbi.nlm.nih.gov/pubmed/10659995
PubMed	10913335	http://www.ncbi.nlm.nih.gov/pubmed/10913335
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
Reactome	R-HSA-1296041	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296041
Reactome	R-HSA-997272	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-997272
RefSeq	NP_004974	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004974
SMR	Q92806	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q92806
STRING	9606.ENSP00000357067	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000357067&targetmode=cogs
SUPFAM	SSF81296	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81296
UCSC	uc001fuy	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001fuy&org=rat
UniGene	Hs.66726	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.66726
UniProtKB	KCNJ9_HUMAN	http://www.uniprot.org/uniprot/KCNJ9_HUMAN
UniProtKB-AC	Q92806	http://www.uniprot.org/uniprot/Q92806
charge	swissprot:KCNJ9_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNJ9_HUMAN
eggNOG	ENOG410XQ62	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ62
eggNOG	KOG3827	http://eggnogapi.embl.de/nog_data/html/tree/KOG3827
epestfind	swissprot:KCNJ9_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNJ9_HUMAN
garnier	swissprot:KCNJ9_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNJ9_HUMAN
helixturnhelix	swissprot:KCNJ9_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNJ9_HUMAN
hmoment	swissprot:KCNJ9_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNJ9_HUMAN
iep	swissprot:KCNJ9_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNJ9_HUMAN
inforesidue	swissprot:KCNJ9_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNJ9_HUMAN
neXtProt	NX_Q92806	http://www.nextprot.org/db/entry/NX_Q92806
octanol	swissprot:KCNJ9_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNJ9_HUMAN
pepcoil	swissprot:KCNJ9_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNJ9_HUMAN
pepdigest	swissprot:KCNJ9_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNJ9_HUMAN
pepinfo	swissprot:KCNJ9_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNJ9_HUMAN
pepnet	swissprot:KCNJ9_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNJ9_HUMAN
pepstats	swissprot:KCNJ9_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNJ9_HUMAN
pepwheel	swissprot:KCNJ9_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNJ9_HUMAN
pepwindow	swissprot:KCNJ9_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNJ9_HUMAN
sigcleave	swissprot:KCNJ9_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNJ9_HUMAN
## Database	ID	URL or Descriptions
# AltName	GBRG1_HUMAN	GABA(A) receptor subunit gamma-1
# DrugBank	DB00186	Lorazepam
# DrugBank	DB00189	Ethchlorvynol
# DrugBank	DB00228	Enflurane
# DrugBank	DB00231	Temazepam
# DrugBank	DB00237	Butabarbital
# DrugBank	DB00241	Butalbital
# DrugBank	DB00273	Topiramate
# DrugBank	DB00292	Etomidate
# DrugBank	DB00306	Talbutal
# DrugBank	DB00312	Pentobarbital
# DrugBank	DB00334	Olanzapine
# DrugBank	DB00349	Clobazam
# DrugBank	DB00371	Meprobamate
# DrugBank	DB00402	Eszopiclone
# DrugBank	DB00404	Alprazolam
# DrugBank	DB00475	Chlordiazepoxide
# DrugBank	DB00543	Amoxapine
# DrugBank	DB00546	Adinazolam
# DrugBank	DB00628	Clorazepate
# DrugBank	DB00659	Acamprosate
# DrugBank	DB00683	Midazolam
# DrugBank	DB00690	Flurazepam
# DrugBank	DB00753	Isoflurane
# DrugBank	DB00794	Primidone
# DrugBank	DB00801	Halazepam
# DrugBank	DB00818	Propofol
# DrugBank	DB00829	Diazepam
# DrugBank	DB00842	Oxazepam
# DrugBank	DB00897	Triazolam
# DrugBank	DB00898	Ethanol
# DrugBank	DB01028	Methoxyflurane
# DrugBank	DB01049	Ergoloid mesylate
# DrugBank	DB01068	Clonazepam
# DrugBank	DB01107	Methyprylon
# DrugBank	DB01159	Halothane
# DrugBank	DB01189	Desflurane
# DrugBank	DB01205	Flumazenil
# DrugBank	DB01215	Estazolam
# DrugBank	DB01236	Sevoflurane
# DrugBank	DB01437	Glutethimide
# DrugBank	DB01558	Bromazepam
# DrugBank	DB01559	Clotiazepam
# DrugBank	DB01567	Fludiazepam
# DrugBank	DB01587	Ketazolam
# DrugBank	DB01588	Prazepam
# DrugBank	DB01589	Quazepam
# DrugBank	DB01594	Cinolazepam
# DrugBank	DB01595	Nitrazepam
# Ensembl	ENST00000295452	ENSP00000295452; ENSG00000163285
# FUNCTION	GBRG1_HUMAN	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. 
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:1902711	GABA-A receptor complex; IBA:GO_Central.
# GO_function	GO:0004890	GABA-A receptor activity; IEA:Ensembl.
# GO_function	GO:0005230	extracellular ligand-gated ion channel activity; IEA:InterPro.
# GO_function	GO:0005254	chloride channel activity; IEA:UniProtKB-KW.
# GO_process	GO:0007214	gamma-aminobutyric acid signaling pathway; IEA:InterPro.
# GO_process	GO:0007268	chemical synaptic transmission; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# Gene3D	2.70.170.10	-; 1.
# Genevisible	Q8N1C3	HS
# HGNC	HGNC:4086	GABRG1
# InterPro	IPR005437	GABBAg_rcpt
# InterPro	IPR005438	GABBAg1_rcpt
# InterPro	IPR006028	GABAA/Glycine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04727	GABAergic synapse
# KEGG_Pathway	ko05032	Morphine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# MIM	137166	gene
# MISCELLANEOUS	GBRG1_HUMAN	This subunit carries the benzodiazepine binding site. 
# Organism	GBRG1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR18945	PTHR18945
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00253	GABAARECEPTR
# PRINTS	PR01620	GABAARGAMMA
# PRINTS	PR01621	GABAARGAMMA1
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# PTM	GBRG1_HUMAN	May be palmitoylated. {ECO 0000250}. 
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 4
# RecName	GBRG1_HUMAN	Gamma-aminobutyric acid receptor subunit gamma-1
# RefSeq	NP_775807	NM_173536.3
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG1 sub-subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	GBRG1_HUMAN	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Generally pentameric. There are five types of GABA(A) receptor chains	 alpha, beta, gamma, delta, and rho. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TIGRFAMs	TIGR00860	LIC
# UCSC	uc003gxb	human
# WEB RESOURCE	GBRG1_HUMAN	Name=Protein Spotlight; Note=Forbidden fruit - Issue 56 of March 2005; URL="http //web.expasy.org/spotlight/back_issues/056";
# eggNOG	ENOG410XNQG	LUCA
# eggNOG	KOG3642	Eukaryota
BLAST	swissprot:GBRG1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GBRG1_HUMAN
BioCyc	ZFISH:ENSG00000163285-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000163285-MONOMER
COXPRESdb	2565	http://coxpresdb.jp/data/gene/2565.shtml
CleanEx	HS_GABRG1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GABRG1
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DrugBank	DB00186	http://www.drugbank.ca/drugs/DB00186
DrugBank	DB00189	http://www.drugbank.ca/drugs/DB00189
DrugBank	DB00228	http://www.drugbank.ca/drugs/DB00228
DrugBank	DB00231	http://www.drugbank.ca/drugs/DB00231
DrugBank	DB00237	http://www.drugbank.ca/drugs/DB00237
DrugBank	DB00241	http://www.drugbank.ca/drugs/DB00241
DrugBank	DB00273	http://www.drugbank.ca/drugs/DB00273
DrugBank	DB00292	http://www.drugbank.ca/drugs/DB00292
DrugBank	DB00306	http://www.drugbank.ca/drugs/DB00306
DrugBank	DB00312	http://www.drugbank.ca/drugs/DB00312
DrugBank	DB00334	http://www.drugbank.ca/drugs/DB00334
DrugBank	DB00349	http://www.drugbank.ca/drugs/DB00349
DrugBank	DB00371	http://www.drugbank.ca/drugs/DB00371
DrugBank	DB00402	http://www.drugbank.ca/drugs/DB00402
DrugBank	DB00404	http://www.drugbank.ca/drugs/DB00404
DrugBank	DB00475	http://www.drugbank.ca/drugs/DB00475
DrugBank	DB00543	http://www.drugbank.ca/drugs/DB00543
DrugBank	DB00546	http://www.drugbank.ca/drugs/DB00546
DrugBank	DB00628	http://www.drugbank.ca/drugs/DB00628
DrugBank	DB00659	http://www.drugbank.ca/drugs/DB00659
DrugBank	DB00683	http://www.drugbank.ca/drugs/DB00683
DrugBank	DB00690	http://www.drugbank.ca/drugs/DB00690
DrugBank	DB00753	http://www.drugbank.ca/drugs/DB00753
DrugBank	DB00794	http://www.drugbank.ca/drugs/DB00794
DrugBank	DB00801	http://www.drugbank.ca/drugs/DB00801
DrugBank	DB00818	http://www.drugbank.ca/drugs/DB00818
DrugBank	DB00829	http://www.drugbank.ca/drugs/DB00829
DrugBank	DB00842	http://www.drugbank.ca/drugs/DB00842
DrugBank	DB00897	http://www.drugbank.ca/drugs/DB00897
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01028	http://www.drugbank.ca/drugs/DB01028
DrugBank	DB01049	http://www.drugbank.ca/drugs/DB01049
DrugBank	DB01068	http://www.drugbank.ca/drugs/DB01068
DrugBank	DB01107	http://www.drugbank.ca/drugs/DB01107
DrugBank	DB01159	http://www.drugbank.ca/drugs/DB01159
DrugBank	DB01189	http://www.drugbank.ca/drugs/DB01189
DrugBank	DB01205	http://www.drugbank.ca/drugs/DB01205
DrugBank	DB01215	http://www.drugbank.ca/drugs/DB01215
DrugBank	DB01236	http://www.drugbank.ca/drugs/DB01236
DrugBank	DB01437	http://www.drugbank.ca/drugs/DB01437
DrugBank	DB01558	http://www.drugbank.ca/drugs/DB01558
DrugBank	DB01559	http://www.drugbank.ca/drugs/DB01559
DrugBank	DB01567	http://www.drugbank.ca/drugs/DB01567
DrugBank	DB01587	http://www.drugbank.ca/drugs/DB01587
DrugBank	DB01588	http://www.drugbank.ca/drugs/DB01588
DrugBank	DB01589	http://www.drugbank.ca/drugs/DB01589
DrugBank	DB01594	http://www.drugbank.ca/drugs/DB01594
DrugBank	DB01595	http://www.drugbank.ca/drugs/DB01595
EMBL	AK122845	http://www.ebi.ac.uk/ena/data/view/AK122845
EMBL	BC031087	http://www.ebi.ac.uk/ena/data/view/BC031087
EMBL	CH471069	http://www.ebi.ac.uk/ena/data/view/CH471069
EMBL	CR933628	http://www.ebi.ac.uk/ena/data/view/CR933628
Ensembl	ENST00000295452	http://www.ensembl.org/id/ENST00000295452
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_component	GO:1902711	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902711
GO_function	GO:0004890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004890
GO_function	GO:0005230	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005230
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_process	GO:0007214	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007214
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	GABRG1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GABRG1
GeneID	2565	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2565
GeneTree	ENSGT00760000119010	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119010
HGNC	HGNC:4086	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4086
HOGENOM	HOG000231337	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231337&db=HOGENOM6
HOVERGEN	HBG051707	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051707&db=HOVERGEN
HPA	HPA035622	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035622
InParanoid	Q8N1C3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8N1C3
InterPro	IPR005437	http://www.ebi.ac.uk/interpro/entry/IPR005437
InterPro	IPR005438	http://www.ebi.ac.uk/interpro/entry/IPR005438
InterPro	IPR006028	http://www.ebi.ac.uk/interpro/entry/IPR006028
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
Jabion	2565	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2565
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:2565	http://www.genome.jp/dbget-bin/www_bget?hsa:2565
KEGG_Orthology	KO:K05186	http://www.genome.jp/dbget-bin/www_bget?KO:K05186
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
KEGG_Pathway	ko05032	http://www.genome.jp/kegg-bin/show_pathway?ko05032
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
MIM	137166	http://www.ncbi.nlm.nih.gov/omim/137166
OMA	VRLMFLL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VRLMFLL
OrthoDB	EOG091G0805	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0805
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00253	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00253
PRINTS	PR01620	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01620
PRINTS	PR01621	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01621
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:GBRG1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GBRG1_HUMAN
PSORT-B	swissprot:GBRG1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GBRG1_HUMAN
PSORT2	swissprot:GBRG1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GBRG1_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA28500	http://www.pharmgkb.org/do/serve?objId=PA28500&objCls=Gene
Phobius	swissprot:GBRG1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GBRG1_HUMAN
PhylomeDB	Q8N1C3	http://phylomedb.org/?seqid=Q8N1C3
ProteinModelPortal	Q8N1C3	http://www.proteinmodelportal.org/query/uniprot/Q8N1C3
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
RefSeq	NP_775807	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_775807
STRING	9606.ENSP00000295452	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000295452&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc003gxb	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003gxb&org=rat
UniGene	Hs.375051	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.375051
UniProtKB	GBRG1_HUMAN	http://www.uniprot.org/uniprot/GBRG1_HUMAN
UniProtKB-AC	Q8N1C3	http://www.uniprot.org/uniprot/Q8N1C3
charge	swissprot:GBRG1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GBRG1_HUMAN
eggNOG	ENOG410XNQG	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNQG
eggNOG	KOG3642	http://eggnogapi.embl.de/nog_data/html/tree/KOG3642
epestfind	swissprot:GBRG1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GBRG1_HUMAN
garnier	swissprot:GBRG1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GBRG1_HUMAN
helixturnhelix	swissprot:GBRG1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GBRG1_HUMAN
hmoment	swissprot:GBRG1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GBRG1_HUMAN
iep	swissprot:GBRG1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GBRG1_HUMAN
inforesidue	swissprot:GBRG1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GBRG1_HUMAN
neXtProt	NX_Q8N1C3	http://www.nextprot.org/db/entry/NX_Q8N1C3
octanol	swissprot:GBRG1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GBRG1_HUMAN
pepcoil	swissprot:GBRG1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GBRG1_HUMAN
pepdigest	swissprot:GBRG1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GBRG1_HUMAN
pepinfo	swissprot:GBRG1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GBRG1_HUMAN
pepnet	swissprot:GBRG1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GBRG1_HUMAN
pepstats	swissprot:GBRG1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GBRG1_HUMAN
pepwheel	swissprot:GBRG1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GBRG1_HUMAN
pepwindow	swissprot:GBRG1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GBRG1_HUMAN
sigcleave	swissprot:GBRG1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GBRG1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S12A9_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9BXP2-1; Sequence=Displayed; Name=2; IsoId=Q9BXP2-2; Sequence=VSP_033192, VSP_033193, VSP_033194; Note=No experimental confirmation available.; Name=3; IsoId=Q9BXP2-3; Sequence=VSP_033193, VSP_033194; Note=No experimental confirmation available.; Name=4; IsoId=Q9BXP2-4; Sequence=VSP_045591, VSP_045592; Note=No experimental confirmation available.; 
# AltName	S12A9_HUMAN	Cation-chloride cotransporter 6
# AltName	S12A9_HUMAN	Cation-chloride cotransporter-interacting protein 1
# AltName	S12A9_HUMAN	Potassium-chloride transporter 9
# AltName	S12A9_HUMAN	WO3.3
# BioGrid	121311	20
# CCDS	CCDS5707	-. [Q9BXP2-1]
# CCDS	CCDS59068	-. [Q9BXP2-4]
# CCDS	CCDS59069	-. [Q9BXP2-2]
# ChiTaRS	SLC12A9	human
# Ensembl	ENST00000354161	ENSP00000275730; ENSG00000146828. [Q9BXP2-1]
# Ensembl	ENST00000415287	ENSP00000413796; ENSG00000146828. [Q9BXP2-2]
# Ensembl	ENST00000540482	ENSP00000443702; ENSG00000146828. [Q9BXP2-4]
# ExpressionAtlas	Q9BXP2	baseline and differential
# FUNCTION	S12A9_HUMAN	May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function. {ECO 0000269|PubMed 10871601}. 
# GO_component	GO:0005886	plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0022820	potassium ion symporter activity; IBA:GO_Central.
# GO_function	S12A9_HUMAN	GO 0015377 cation chloride symporter activity; TAS ProtInc.
# GO_function	S12A9_HUMAN	GO 0015379 potassium chloride symporter activity; IBA GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# Genevisible	Q9BXP2	HS
# HGNC	HGNC:17435	SLC12A9
# IntAct	Q9BXP2	2
# InterPro	IPR004841	AA-permease/SLC12A_dom
# InterPro	IPR018491	SLC12_C
# InterPro	IPR030345	SLC12A9
# KEGG_Brite	ko02001	Solute carrier family
# MIM	616861	gene
# Organism	S12A9_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11827:SF52	PTHR11827:SF52; 2
# Pfam	PF00324	AA_permease
# Pfam	PF03522	SLC12
# Proteomes	UP000005640	Chromosome 7
# RecName	S12A9_HUMAN	Solute carrier family 12 member 9
# RefSeq	NP_001254741	NM_001267812.1. [Q9BXP2-4]
# RefSeq	NP_001254743	NM_001267814.1. [Q9BXP2-2]
# RefSeq	NP_064631	NM_020246.3. [Q9BXP2-1]
# SIMILARITY	Belongs to the SLC12A transporter family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S12A9_HUMAN	Cell membrane {ECO 0000269|PubMed 10871601}; Multi-pass membrane protein {ECO 0000269|PubMed 10871601}. 
# SUBUNIT	Interacts with SLC12A1. {ECO:0000269|PubMed	10871601}. 
# TCDB	2.A.30.3	the cation-chloride cotransporter (ccc) family
# TISSUE SPECIFICITY	S12A9_HUMAN	Highly expressed in placenta, brain and kidney. Lower expression in lung, liver and heart. 
# UCSC	uc003uwp	human. [Q9BXP2-1]
# eggNOG	COG0531	LUCA
# eggNOG	KOG1288	Eukaryota
BLAST	swissprot:S12A9_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S12A9_HUMAN
COXPRESdb	56996	http://coxpresdb.jp/data/gene/56996.shtml
CleanEx	HS_SLC12A9	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC12A9
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M000108200	http://dx.doi.org/10.1074/jbc.M000108200
DOI	10.1093/nar/29.6.1352	http://dx.doi.org/10.1093/nar/29.6.1352
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB033284	http://www.ebi.ac.uk/ena/data/view/AB033284
EMBL	AC011895	http://www.ebi.ac.uk/ena/data/view/AC011895
EMBL	AF284422	http://www.ebi.ac.uk/ena/data/view/AF284422
EMBL	AF312032	http://www.ebi.ac.uk/ena/data/view/AF312032
EMBL	AF312032	http://www.ebi.ac.uk/ena/data/view/AF312032
EMBL	AK301411	http://www.ebi.ac.uk/ena/data/view/AK301411
EMBL	BC000154	http://www.ebi.ac.uk/ena/data/view/BC000154
EMBL	CH236956	http://www.ebi.ac.uk/ena/data/view/CH236956
EMBL	CH471091	http://www.ebi.ac.uk/ena/data/view/CH471091
EMBL	CH471091	http://www.ebi.ac.uk/ena/data/view/CH471091
EMBL	CH471091	http://www.ebi.ac.uk/ena/data/view/CH471091
EMBL	CH471091	http://www.ebi.ac.uk/ena/data/view/CH471091
EMBL	CH471091	http://www.ebi.ac.uk/ena/data/view/CH471091
EMBL	CH471091	http://www.ebi.ac.uk/ena/data/view/CH471091
Ensembl	ENST00000354161	http://www.ensembl.org/id/ENST00000354161
Ensembl	ENST00000415287	http://www.ensembl.org/id/ENST00000415287
Ensembl	ENST00000540482	http://www.ensembl.org/id/ENST00000540482
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0015377	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015377
GO_function	GO:0015379	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015379
GO_function	GO:0022820	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022820
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GeneCards	SLC12A9	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC12A9
GeneID	56996	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56996
GeneTree	ENSGT00760000119053	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119053
H-InvDB	HIX0201124	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0201124
HGNC	HGNC:17435	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17435
HOGENOM	HOG000018183	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000018183&db=HOGENOM6
HOVERGEN	HBG106223	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG106223&db=HOVERGEN
InParanoid	Q9BXP2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9BXP2
IntAct	Q9BXP2	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9BXP2*
InterPro	IPR004841	http://www.ebi.ac.uk/interpro/entry/IPR004841
InterPro	IPR018491	http://www.ebi.ac.uk/interpro/entry/IPR018491
InterPro	IPR030345	http://www.ebi.ac.uk/interpro/entry/IPR030345
Jabion	56996	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=56996
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:56996	http://www.genome.jp/dbget-bin/www_bget?hsa:56996
KEGG_Orthology	KO:K14429	http://www.genome.jp/dbget-bin/www_bget?KO:K14429
MIM	616861	http://www.ncbi.nlm.nih.gov/omim/616861
OMA	ISGCTEG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ISGCTEG
OrthoDB	EOG091G02RC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02RC
PANTHER	PTHR11827:SF52	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11827:SF52
PSORT	swissprot:S12A9_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S12A9_HUMAN
PSORT-B	swissprot:S12A9_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S12A9_HUMAN
PSORT2	swissprot:S12A9_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S12A9_HUMAN
Pfam	PF00324	http://pfam.xfam.org/family/PF00324
Pfam	PF03522	http://pfam.xfam.org/family/PF03522
PharmGKB	PA134921585	http://www.pharmgkb.org/do/serve?objId=PA134921585&objCls=Gene
Phobius	swissprot:S12A9_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S12A9_HUMAN
PhylomeDB	Q9BXP2	http://phylomedb.org/?seqid=Q9BXP2
ProteinModelPortal	Q9BXP2	http://www.proteinmodelportal.org/query/uniprot/Q9BXP2
PubMed	10871601	http://www.ncbi.nlm.nih.gov/pubmed/10871601
PubMed	11239002	http://www.ncbi.nlm.nih.gov/pubmed/11239002
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
RefSeq	NP_001254741	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001254741
RefSeq	NP_001254743	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001254743
RefSeq	NP_064631	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_064631
STRING	9606.ENSP00000275730	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000275730&targetmode=cogs
TCDB	2.A.30.3	http://www.tcdb.org/search/result.php?tc=2.A.30.3
UCSC	uc003uwp	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003uwp&org=rat
UniGene	Hs.521087	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.521087
UniProtKB	S12A9_HUMAN	http://www.uniprot.org/uniprot/S12A9_HUMAN
UniProtKB-AC	Q9BXP2	http://www.uniprot.org/uniprot/Q9BXP2
charge	swissprot:S12A9_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S12A9_HUMAN
eggNOG	COG0531	http://eggnogapi.embl.de/nog_data/html/tree/COG0531
eggNOG	KOG1288	http://eggnogapi.embl.de/nog_data/html/tree/KOG1288
epestfind	swissprot:S12A9_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S12A9_HUMAN
garnier	swissprot:S12A9_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S12A9_HUMAN
helixturnhelix	swissprot:S12A9_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S12A9_HUMAN
hmoment	swissprot:S12A9_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S12A9_HUMAN
iep	swissprot:S12A9_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S12A9_HUMAN
inforesidue	swissprot:S12A9_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S12A9_HUMAN
neXtProt	NX_Q9BXP2	http://www.nextprot.org/db/entry/NX_Q9BXP2
octanol	swissprot:S12A9_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S12A9_HUMAN
pepcoil	swissprot:S12A9_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S12A9_HUMAN
pepdigest	swissprot:S12A9_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S12A9_HUMAN
pepinfo	swissprot:S12A9_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S12A9_HUMAN
pepnet	swissprot:S12A9_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S12A9_HUMAN
pepstats	swissprot:S12A9_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S12A9_HUMAN
pepwheel	swissprot:S12A9_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S12A9_HUMAN
pepwindow	swissprot:S12A9_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S12A9_HUMAN
sigcleave	swissprot:S12A9_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S12A9_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	FA26F_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5R3K3-1; Sequence=Displayed; Name=2; IsoId=Q5R3K3-2; Sequence=VSP_055698, VSP_055699; Note=No experimental confirmation available. Gene prediction based on EST data.; 
# CCDS	CCDS34519	-. [Q5R3K3-1]
# CCDS	CCDS64506	-. [Q5R3K3-2]
# ChiTaRS	FAM26F	human
# Ensembl	ENST00000368605	ENSP00000357594; ENSG00000188820. [Q5R3K3-1]
# Ensembl	ENST00000368606	ENSP00000357595; ENSG00000188820. [Q5R3K3-2]
# ExpressionAtlas	Q5R3K3	baseline and differential
# FUNCTION	FA26F_HUMAN	Pore-forming subunit of a voltage-gated ion channel. {ECO 0000250}. 
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0005261	cation channel activity; IBA:GO_Central.
# GO_process	GO:0034220	ion transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q5R3K3	HS
# HGNC	HGNC:33391	FAM26F
# InterPro	IPR029569	FAM26
# Organism	FA26F_HUMAN	Homo sapiens (Human)
# Pfam	PF14798	Ca_hom_mod
# Proteomes	UP000005640	Chromosome 6
# RecName	FA26F_HUMAN	Protein FAM26F
# RefSeq	NP_001010919	NM_001010919.2. [Q5R3K3-1]
# RefSeq	NP_001263389	NM_001276460.1. [Q5R3K3-2]
# RefSeq	XP_005267056	XM_005266999.3. [Q5R3K3-1]
# SIMILARITY	Belongs to the FAM26 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	FA26F_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# UCSC	uc003pwv	human. [Q5R3K3-1]
# eggNOG	ENOG410IGW7	Eukaryota
# eggNOG	ENOG41115FT	LUCA
BLAST	swissprot:FA26F_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:FA26F_HUMAN
BioCyc	ZFISH:G66-31668-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31668-MONOMER
COXPRESdb	441168	http://coxpresdb.jp/data/gene/441168.shtml
CleanEx	HS_FAM26F	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_FAM26F
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	BC146842	http://www.ebi.ac.uk/ena/data/view/BC146842
EMBL	CH471051	http://www.ebi.ac.uk/ena/data/view/CH471051
EMBL	Z84488	http://www.ebi.ac.uk/ena/data/view/Z84488
Ensembl	ENST00000368605	http://www.ensembl.org/id/ENST00000368605
Ensembl	ENST00000368606	http://www.ensembl.org/id/ENST00000368606
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005261	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005261
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	FAM26F	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=FAM26F
GeneID	441168	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=441168
GeneTree	ENSGT00530000062796	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062796
HGNC	HGNC:33391	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:33391
HOGENOM	HOG000294134	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294134&db=HOGENOM6
HOVERGEN	HBG056946	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG056946&db=HOVERGEN
HPA	HPA017948	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA017948
HPA	HPA062365	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA062365
InParanoid	Q5R3K3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q5R3K3
InterPro	IPR029569	http://www.ebi.ac.uk/interpro/entry/IPR029569
Jabion	441168	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=441168
KEGG_Gene	hsa:441168	http://www.genome.jp/dbget-bin/www_bget?hsa:441168
OMA	PCNQAKA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PCNQAKA
OrthoDB	EOG091G0BN1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0BN1
PSORT	swissprot:FA26F_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:FA26F_HUMAN
PSORT-B	swissprot:FA26F_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:FA26F_HUMAN
PSORT2	swissprot:FA26F_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:FA26F_HUMAN
Pfam	PF14798	http://pfam.xfam.org/family/PF14798
PharmGKB	PA162387644	http://www.pharmgkb.org/do/serve?objId=PA162387644&objCls=Gene
Phobius	swissprot:FA26F_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:FA26F_HUMAN
PhylomeDB	Q5R3K3	http://phylomedb.org/?seqid=Q5R3K3
ProteinModelPortal	Q5R3K3	http://www.proteinmodelportal.org/query/uniprot/Q5R3K3
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
RefSeq	NP_001010919	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001010919
RefSeq	NP_001263389	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001263389
RefSeq	XP_005267056	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005267056
STRING	9606.ENSP00000357594	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000357594&targetmode=cogs
UCSC	uc003pwv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003pwv&org=rat
UniGene	Hs.381220	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.381220
UniProtKB	FA26F_HUMAN	http://www.uniprot.org/uniprot/FA26F_HUMAN
UniProtKB-AC	Q5R3K3	http://www.uniprot.org/uniprot/Q5R3K3
charge	swissprot:FA26F_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:FA26F_HUMAN
eggNOG	ENOG410IGW7	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IGW7
eggNOG	ENOG41115FT	http://eggnogapi.embl.de/nog_data/html/tree/ENOG41115FT
epestfind	swissprot:FA26F_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:FA26F_HUMAN
garnier	swissprot:FA26F_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:FA26F_HUMAN
helixturnhelix	swissprot:FA26F_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:FA26F_HUMAN
hmoment	swissprot:FA26F_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:FA26F_HUMAN
iep	swissprot:FA26F_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:FA26F_HUMAN
inforesidue	swissprot:FA26F_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:FA26F_HUMAN
neXtProt	NX_Q5R3K3	http://www.nextprot.org/db/entry/NX_Q5R3K3
octanol	swissprot:FA26F_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:FA26F_HUMAN
pepcoil	swissprot:FA26F_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:FA26F_HUMAN
pepdigest	swissprot:FA26F_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:FA26F_HUMAN
pepinfo	swissprot:FA26F_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:FA26F_HUMAN
pepnet	swissprot:FA26F_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:FA26F_HUMAN
pepstats	swissprot:FA26F_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:FA26F_HUMAN
pepwheel	swissprot:FA26F_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:FA26F_HUMAN
pepwindow	swissprot:FA26F_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:FA26F_HUMAN
sigcleave	swissprot:FA26F_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:FA26F_HUMAN
## Database	ID	URL or Descriptions
# AltName	VACHT_HUMAN	Solute carrier family 18 member 3
# CDD	cd06174	MFS
# Ensembl	ENST00000374115	ENSP00000363229; ENSG00000187714
# FUNCTION	VACHT_HUMAN	Involved in acetylcholine transport into synaptic vesicles. {ECO 0000269|PubMed 8071310}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0030121	AP-1 adaptor complex; IBA:GO_Central.
# GO_component	GO:0030122	AP-2 adaptor complex; IBA:GO_Central.
# GO_component	GO:0030672	synaptic vesicle membrane; IBA:GO_Central.
# GO_component	GO:0043195	terminal bouton; IBA:GO_Central.
# GO_component	GO:0060201	clathrin-sculpted acetylcholine transport vesicle membrane; TAS:Reactome.
# GO_function	GO:0005277	acetylcholine transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0008504	monoamine transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0042166	acetylcholine binding; IBA:GO_Central.
# GO_process	GO:0007268	chemical synaptic transmission; IBA:GO_Central.
# GO_process	GO:0007269	neurotransmitter secretion; TAS:Reactome.
# GO_process	GO:0015870	acetylcholine transport; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# Genevisible	Q16572	HS
# HGNC	HGNC:10936	SLC18A3
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04725	Cholinergic synapse
# MIM	600336	gene
# Organism	VACHT_HUMAN	Homo sapiens (Human)
# PIR	I38658	I38658
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 10
# Reactome	R-HSA-264642	Acetylcholine Neurotransmitter Release Cycle
# Reactome	R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis
# Reactome	R-HSA-8856828	Clathrin-mediated endocytosis
# RecName	VACHT_HUMAN	Vesicular acetylcholine transporter
# RefSeq	NP_003046	NM_003055.2
# SIMILARITY	Belongs to the major facilitator superfamily. Vesicular transporter family. {ECO	0000305}.
# SUBCELLULAR LOCATION	VACHT_HUMAN	Membrane {ECO 0000255}; Multi-pass membrane protein {ECO 0000255}. 
# SUBUNIT	Interacts with SEC14L1. {ECO:0000269|PubMed	17092608}. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.1.2.28	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	Peripheral and central cholinergic nervous systems. {ECO:0000269|PubMed	8071310}. 
# UCSC	uc001jhw	human
# eggNOG	ENOG410XW69	LUCA
# eggNOG	KOG3764	Eukaryota
BLAST	swissprot:VACHT_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VACHT_HUMAN
BioCyc	ZFISH:G66-31718-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31718-MONOMER
COXPRESdb	6572	http://coxpresdb.jp/data/gene/6572.shtml
CleanEx	HS_SLC18A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC18A3
DOI	10.1016/j.neuint.2006.09.010	http://dx.doi.org/10.1016/j.neuint.2006.09.010
DOI	10.1038/nature02462	http://dx.doi.org/10.1038/nature02462
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC073366	http://www.ebi.ac.uk/ena/data/view/AC073366
EMBL	AK313094	http://www.ebi.ac.uk/ena/data/view/AK313094
EMBL	BC007765	http://www.ebi.ac.uk/ena/data/view/BC007765
EMBL	CH471187	http://www.ebi.ac.uk/ena/data/view/CH471187
EMBL	U09210	http://www.ebi.ac.uk/ena/data/view/U09210
EMBL	U10554	http://www.ebi.ac.uk/ena/data/view/U10554
Ensembl	ENST00000374115	http://www.ensembl.org/id/ENST00000374115
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0030121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030121
GO_component	GO:0030122	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030122
GO_component	GO:0030672	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030672
GO_component	GO:0043195	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043195
GO_component	GO:0060201	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060201
GO_function	GO:0005277	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005277
GO_function	GO:0008504	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008504
GO_function	GO:0042166	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042166
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007269	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007269
GO_process	GO:0015870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015870
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GeneCards	SLC18A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC18A3
GeneID	6572	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6572
GeneTree	ENSGT00390000003851	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000003851
HGNC	HGNC:10936	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10936
HOGENOM	HOG000018545	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000018545&db=HOGENOM6
HOVERGEN	HBG055082	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG055082&db=HOVERGEN
HPA	CAB037102	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB037102
InParanoid	Q16572	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q16572
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	6572	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6572
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6572	http://www.genome.jp/dbget-bin/www_bget?hsa:6572
KEGG_Orthology	KO:K14636	http://www.genome.jp/dbget-bin/www_bget?KO:K14636
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04725	http://www.genome.jp/kegg-bin/show_pathway?ko04725
MIM	600336	http://www.ncbi.nlm.nih.gov/omim/600336
OMA	EVWEPTL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EVWEPTL
OrthoDB	EOG091G0534	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0534
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:VACHT_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VACHT_HUMAN
PSORT-B	swissprot:VACHT_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VACHT_HUMAN
PSORT2	swissprot:VACHT_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VACHT_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA326	http://www.pharmgkb.org/do/serve?objId=PA326&objCls=Gene
Phobius	swissprot:VACHT_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VACHT_HUMAN
PhylomeDB	Q16572	http://phylomedb.org/?seqid=Q16572
ProteinModelPortal	Q16572	http://www.proteinmodelportal.org/query/uniprot/Q16572
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15164054	http://www.ncbi.nlm.nih.gov/pubmed/15164054
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17092608	http://www.ncbi.nlm.nih.gov/pubmed/17092608
PubMed	8071310	http://www.ncbi.nlm.nih.gov/pubmed/8071310
Reactome	R-HSA-264642	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-264642
Reactome	R-HSA-8856825	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8856825
Reactome	R-HSA-8856828	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8856828
RefSeq	NP_003046	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003046
STRING	9606.ENSP00000363229	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000363229&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.2.28	http://www.tcdb.org/search/result.php?tc=2.A.1.2.28
UCSC	uc001jhw	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001jhw&org=rat
UniGene	Hs.654374	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.654374
UniProtKB	VACHT_HUMAN	http://www.uniprot.org/uniprot/VACHT_HUMAN
UniProtKB-AC	Q16572	http://www.uniprot.org/uniprot/Q16572
charge	swissprot:VACHT_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VACHT_HUMAN
eggNOG	ENOG410XW69	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XW69
eggNOG	KOG3764	http://eggnogapi.embl.de/nog_data/html/tree/KOG3764
epestfind	swissprot:VACHT_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VACHT_HUMAN
garnier	swissprot:VACHT_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VACHT_HUMAN
helixturnhelix	swissprot:VACHT_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VACHT_HUMAN
hmoment	swissprot:VACHT_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VACHT_HUMAN
iep	swissprot:VACHT_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VACHT_HUMAN
inforesidue	swissprot:VACHT_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VACHT_HUMAN
neXtProt	NX_Q16572	http://www.nextprot.org/db/entry/NX_Q16572
octanol	swissprot:VACHT_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VACHT_HUMAN
pepcoil	swissprot:VACHT_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VACHT_HUMAN
pepdigest	swissprot:VACHT_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VACHT_HUMAN
pepinfo	swissprot:VACHT_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VACHT_HUMAN
pepnet	swissprot:VACHT_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VACHT_HUMAN
pepstats	swissprot:VACHT_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VACHT_HUMAN
pepwheel	swissprot:VACHT_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VACHT_HUMAN
pepwindow	swissprot:VACHT_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VACHT_HUMAN
sigcleave	swissprot:VACHT_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VACHT_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TRPM1_HUMAN	Event=Alternative splicing; Named isoforms=7; Name=1 {ECO 0000269|PubMed 16572171}; IsoId=Q7Z4N2-1; Sequence=Displayed; Note=No experimental confirmation available. {ECO 0000305}; Name=2 {ECO 0000269|PubMed 9806836, ECO 0000269|Ref.3}; IsoId=Q7Z4N2-2; Sequence=VSP_052748; Name=3 {ECO 0000269|Ref.3}; IsoId=Q7Z4N2-3; Sequence=VSP_052749; Name=4 {ECO 0000269|Ref.3}; IsoId=Q7Z4N2-4; Sequence=VSP_052750; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=5; IsoId=Q7Z4N2-5; Sequence=VSP_046786; Name=6; IsoId=Q7Z4N2-6; Sequence=VSP_046787; Name=7; IsoId=Q7Z4N2-7; Sequence=VSP_046788, VSP_046789; 
# AltName	TRPM1_HUMAN	Long transient receptor potential channel 1
# AltName	TRPM1_HUMAN	Melastatin-1
# BioGrid	110453	4
# CCDS	CCDS10024	-. [Q7Z4N2-1]
# CCDS	CCDS58345	-. [Q7Z4N2-7]
# CCDS	CCDS58346	-. [Q7Z4N2-6]
# CCDS	CCDS58347	-. [Q7Z4N2-5]
# DISEASE	TRPM1_HUMAN	Night blindness, congenital stationary, 1C (CSNB1C) [MIM 613216]  A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia. {ECO 0000269|PubMed 19878917, ECO 0000269|PubMed 19896109, ECO 0000269|PubMed 19896113}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000256552	ENSP00000256552; ENSG00000134160. [Q7Z4N2-6]
# Ensembl	ENST00000397795	ENSP00000380897; ENSG00000134160. [Q7Z4N2-1]
# Ensembl	ENST00000542188	ENSP00000437849; ENSG00000134160. [Q7Z4N2-5]
# Ensembl	ENST00000559179	ENSP00000453851; ENSG00000134160. [Q7Z4N2-7]
# Ensembl	ENST00000560658	ENSP00000454077; ENSG00000134160. [Q7Z4N2-4]
# ExpressionAtlas	Q7Z4N2	baseline and differential
# FUNCTION	TRPM1_HUMAN	Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel. {ECO 0000250, ECO 0000269|PubMed 11535825, ECO 0000269|PubMed 19878917, ECO 0000269|PubMed 19896109}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0035841	new growing cell tip; IEA:Ensembl.
# GO_function	GO:0005262	calcium channel activity; IDA:UniProtKB.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007216	G-protein coupled glutamate receptor signaling pathway; IMP:UniProtKB.
# GO_process	GO:0007601	visual perception; IMP:UniProtKB.
# GO_process	GO:0046548	retinal rod cell development; IEA:Ensembl.
# GO_process	GO:0051262	protein tetramerization; IEA:InterPro.
# GO_process	GO:0060402	calcium ion transport into cytosol; IDA:UniProtKB.
# GO_process	GO:0070588	calcium ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0071482	cellular response to light stimulus; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q7Z4N2	HS
# HGNC	HGNC:7146	TRPM1
# INDUCTION	Up-regulated by hexamethylene bisacetamide (HBMA). {ECO:0000269|PubMed	11112417}. 
# IntAct	Q7Z4N2	2
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR029588	TRPM1
# InterPro	IPR032415	TRPM_tetra
# KEGG_Brite	ko04040	Ion channels
# KEGG_Disease	H00787	[Nervous system disease; Eye disease] Oguchi disease/ CSNB Oguchi type (CSNBO)
# MIM	603576	gene
# MIM	613216	phenotype
# Organism	TRPM1_HUMAN	Homo sapiens (Human)
# Orphanet	215	Congenital stationary night blindness
# PANTHER	PTHR13800:SF13	PTHR13800:SF13; 2
# Pfam	PF00520	Ion_trans
# Pfam	PF16519	TRPM_tetra
# Proteomes	UP000005640	Chromosome 15
# Reactome	R-HSA-3295583	TRP channels
# RecName	TRPM1_HUMAN	Transient receptor potential cation channel subfamily M member 1
# RefSeq	NP_001238949	NM_001252020.1. [Q7Z4N2-5]
# RefSeq	NP_001238953	NM_001252024.1. [Q7Z4N2-6]
# RefSeq	NP_001238959	NM_001252030.1. [Q7Z4N2-7]
# RefSeq	NP_002411	NM_002420.5. [Q7Z4N2-1]
# SIMILARITY	Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM1 sub-subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	TRPM1_HUMAN	Cell membrane {ECO 0000255}; Multi-pass membrane protein {ECO 0000255, ECO 0000269|PubMed 11535825}. 
# TCDB	1.A.4.5	the transient receptor potential ca(2+) channel (trp-cc) family
# TISSUE SPECIFICITY	TRPM1_HUMAN	Expressed in the retina where it localizes to the outer plexiform layer. Highly expressed in benign melanocytic nevi and diffusely expressed in various in situ melanomas, but not detected in melanoma metastases. Also expressed in melanocytes and pigmented metastatic melanoma cell lines. In melanocytes expression appears to be regulated at the level of transcription and mRNA processing. {ECO 0000269|PubMed 11112417, ECO 0000269|PubMed 19896109, ECO 0000269|PubMed 9537257}. 
# UCSC	uc001zfm	human. [Q7Z4N2-1]
# WEB RESOURCE	TRPM1_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/TRPM1ID42707ch15q13.html";
# eggNOG	ENOG410XR5B	LUCA
# eggNOG	KOG3614	Eukaryota
BLAST	swissprot:TRPM1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TRPM1_HUMAN
COXPRESdb	4308	http://coxpresdb.jp/data/gene/4308.shtml
CleanEx	HS_TRPM1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TRPM1
DOI	10.1006/bbrc.2000.3894	http://dx.doi.org/10.1006/bbrc.2000.3894
DOI	10.1006/geno.1998.5549	http://dx.doi.org/10.1006/geno.1998.5549
DOI	10.1016/j.ajhg.2009.10.003	http://dx.doi.org/10.1016/j.ajhg.2009.10.003
DOI	10.1016/j.ajhg.2009.10.012	http://dx.doi.org/10.1016/j.ajhg.2009.10.012
DOI	10.1016/j.ajhg.2009.10.013	http://dx.doi.org/10.1016/j.ajhg.2009.10.013
DOI	10.1038/nature04601	http://dx.doi.org/10.1038/nature04601
DOI	10.1073/pnas.191360198	http://dx.doi.org/10.1073/pnas.191360198
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000146	http://dx.doi.org/10.1126/scisignal.2000146
EMBL	AB115498	http://www.ebi.ac.uk/ena/data/view/AB115498
EMBL	AB115499	http://www.ebi.ac.uk/ena/data/view/AB115499
EMBL	AB115500	http://www.ebi.ac.uk/ena/data/view/AB115500
EMBL	AB115501	http://www.ebi.ac.uk/ena/data/view/AB115501
EMBL	AB115502	http://www.ebi.ac.uk/ena/data/view/AB115502
EMBL	AC009562	http://www.ebi.ac.uk/ena/data/view/AC009562
EMBL	AC090829	http://www.ebi.ac.uk/ena/data/view/AC090829
EMBL	AF071787	http://www.ebi.ac.uk/ena/data/view/AF071787
EMBL	BC058286	http://www.ebi.ac.uk/ena/data/view/BC058286
EMBL	CH471216	http://www.ebi.ac.uk/ena/data/view/CH471216
EMBL	HM135790	http://www.ebi.ac.uk/ena/data/view/HM135790
EMBL	HM135791	http://www.ebi.ac.uk/ena/data/view/HM135791
Ensembl	ENST00000256552	http://www.ensembl.org/id/ENST00000256552
Ensembl	ENST00000397795	http://www.ensembl.org/id/ENST00000397795
Ensembl	ENST00000542188	http://www.ensembl.org/id/ENST00000542188
Ensembl	ENST00000559179	http://www.ensembl.org/id/ENST00000559179
Ensembl	ENST00000560658	http://www.ensembl.org/id/ENST00000560658
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0035841	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035841
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007216	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007216
GO_process	GO:0007601	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007601
GO_process	GO:0046548	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046548
GO_process	GO:0051262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051262
GO_process	GO:0060402	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060402
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:0071482	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071482
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	TRPM1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TRPM1
GeneID	4308	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4308
GeneTree	ENSGT00760000119127	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119127
HGNC	HGNC:7146	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:7146
HOGENOM	HOG000230920	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230920&db=HOGENOM6
HOVERGEN	HBG055663	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG055663&db=HOVERGEN
HPA	HPA014785	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014785
InParanoid	Q7Z4N2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q7Z4N2
IntAct	Q7Z4N2	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q7Z4N2*
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR029588	http://www.ebi.ac.uk/interpro/entry/IPR029588
InterPro	IPR032415	http://www.ebi.ac.uk/interpro/entry/IPR032415
Jabion	4308	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=4308
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00787	http://www.genome.jp/dbget-bin/www_bget?H00787
KEGG_Gene	hsa:4308	http://www.genome.jp/dbget-bin/www_bget?hsa:4308
KEGG_Orthology	KO:K04976	http://www.genome.jp/dbget-bin/www_bget?KO:K04976
MIM	603576	http://www.ncbi.nlm.nih.gov/omim/603576
MIM	613216	http://www.ncbi.nlm.nih.gov/omim/613216
OMA	PPCGEHL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PPCGEHL
Orphanet	215	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=215
OrthoDB	EOG091G0DHL	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0DHL
PANTHER	PTHR13800:SF13	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13800:SF13
PSORT	swissprot:TRPM1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TRPM1_HUMAN
PSORT-B	swissprot:TRPM1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TRPM1_HUMAN
PSORT2	swissprot:TRPM1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TRPM1_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF16519	http://pfam.xfam.org/family/PF16519
PharmGKB	PA35496	http://www.pharmgkb.org/do/serve?objId=PA35496&objCls=Gene
Phobius	swissprot:TRPM1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TRPM1_HUMAN
PhylomeDB	Q7Z4N2	http://phylomedb.org/?seqid=Q7Z4N2
ProteinModelPortal	Q7Z4N2	http://www.proteinmodelportal.org/query/uniprot/Q7Z4N2
PubMed	11112417	http://www.ncbi.nlm.nih.gov/pubmed/11112417
PubMed	11535825	http://www.ncbi.nlm.nih.gov/pubmed/11535825
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16572171	http://www.ncbi.nlm.nih.gov/pubmed/16572171
PubMed	19436059	http://www.ncbi.nlm.nih.gov/pubmed/19436059
PubMed	19878917	http://www.ncbi.nlm.nih.gov/pubmed/19878917
PubMed	19896109	http://www.ncbi.nlm.nih.gov/pubmed/19896109
PubMed	19896113	http://www.ncbi.nlm.nih.gov/pubmed/19896113
PubMed	9537257	http://www.ncbi.nlm.nih.gov/pubmed/9537257
PubMed	9806836	http://www.ncbi.nlm.nih.gov/pubmed/9806836
Reactome	R-HSA-3295583	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3295583
RefSeq	NP_001238949	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001238949
RefSeq	NP_001238953	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001238953
RefSeq	NP_001238959	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001238959
RefSeq	NP_002411	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002411
STRING	9606.ENSP00000380897	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000380897&targetmode=cogs
TCDB	1.A.4.5	http://www.tcdb.org/search/result.php?tc=1.A.4.5
UCSC	uc001zfm	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001zfm&org=rat
UniGene	Hs.155942	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.155942
UniGene	Hs.732541	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.732541
UniProtKB	TRPM1_HUMAN	http://www.uniprot.org/uniprot/TRPM1_HUMAN
UniProtKB-AC	Q7Z4N2	http://www.uniprot.org/uniprot/Q7Z4N2
charge	swissprot:TRPM1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TRPM1_HUMAN
eggNOG	ENOG410XR5B	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XR5B
eggNOG	KOG3614	http://eggnogapi.embl.de/nog_data/html/tree/KOG3614
epestfind	swissprot:TRPM1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TRPM1_HUMAN
garnier	swissprot:TRPM1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TRPM1_HUMAN
helixturnhelix	swissprot:TRPM1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRPM1_HUMAN
hmoment	swissprot:TRPM1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TRPM1_HUMAN
iep	swissprot:TRPM1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TRPM1_HUMAN
inforesidue	swissprot:TRPM1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TRPM1_HUMAN
neXtProt	NX_Q7Z4N2	http://www.nextprot.org/db/entry/NX_Q7Z4N2
octanol	swissprot:TRPM1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TRPM1_HUMAN
pepcoil	swissprot:TRPM1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TRPM1_HUMAN
pepdigest	swissprot:TRPM1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TRPM1_HUMAN
pepinfo	swissprot:TRPM1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TRPM1_HUMAN
pepnet	swissprot:TRPM1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TRPM1_HUMAN
pepstats	swissprot:TRPM1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TRPM1_HUMAN
pepwheel	swissprot:TRPM1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TRPM1_HUMAN
pepwindow	swissprot:TRPM1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TRPM1_HUMAN
sigcleave	swissprot:TRPM1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TRPM1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ABCB8_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=Long; IsoId=Q9NUT2-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q9NUT2-2; Sequence=VSP_000026; Note=No experimental confirmation available.; Name=3; IsoId=Q9NUT2-3; Sequence=VSP_000026, VSP_055297; Note=No experimental confirmation available.; Name=4; IsoId=Q9NUT2-4; Sequence=VSP_056745; Note=No experimental confirmation available.; Name=5; IsoId=Q9NUT2-5; Sequence=VSP_056744; Note=No experimental confirmation available.; 
# AltName	ABCB8_HUMAN	Mitochondrial ATP-binding cassette 1
# BRENDA	3.6.3.43	2681
# BioGrid	116364	25
# CCDS	CCDS5913	-. [Q9NUT2-2]
# CCDS	CCDS64798	-. [Q9NUT2-4]
# CCDS	CCDS64799	-. [Q9NUT2-1]
# CCDS	CCDS64800	-. [Q9NUT2-3]
# ChiTaRS	ABCB8	human
# DrugBank	DB00997	Doxorubicin
# Ensembl	ENST00000297504	ENSP00000297504; ENSG00000197150. [Q9NUT2-1]
# Ensembl	ENST00000358849	ENSP00000351717; ENSG00000197150. [Q9NUT2-2]
# Ensembl	ENST00000498578	ENSP00000418271; ENSG00000197150. [Q9NUT2-3]
# Ensembl	ENST00000542328	ENSP00000438776; ENSG00000197150. [Q9NUT2-4]
# ExpressionAtlas	Q9NUT2	baseline and differential
# GO_component	GO:0005634	nucleus; IDA:HPA.
# GO_component	GO:0005730	nucleolus; IDA:HPA.
# GO_component	GO:0005739	mitochondrion; IDA:HPA.
# GO_component	GO:0005740	mitochondrial envelope; TAS:ProtInc.
# GO_component	GO:0005743	mitochondrial inner membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0043190	ATP-binding cassette (ABC) transporter complex; TAS:ProtInc.
# GO_function	GO:0005215	transporter activity; TAS:ProtInc.
# GO_function	GO:0005524	ATP binding; TAS:ProtInc.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; IBA:GO_Central.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0055085	transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005730	nucleolus
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 1.
# Genevisible	Q9NUT2	HS
# HGNC	HGNC:49	ABCB8
# IntAct	Q9NUT2	2
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR011527	ABC1_TM_dom
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko02010	ABC transporters
# MIM	605464	gene
# Organism	ABCB8_HUMAN	Homo sapiens (Human)
# PROSITE	PS00211	ABC_TRANSPORTER_1
# PROSITE	PS50893	ABC_TRANSPORTER_2
# PROSITE	PS50929	ABC_TM1F
# Pfam	PF00005	ABC_tran
# Pfam	PF00664	ABC_membrane
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-1369007	Mitochondrial ABC transporters
# RecName	ABCB8_HUMAN	ATP-binding cassette sub-family B member 8, mitochondrial
# RefSeq	NP_001269220	NM_001282291.1. [Q9NUT2-1]
# RefSeq	NP_001269221	NM_001282292.1. [Q9NUT2-3]
# RefSeq	NP_001269222	NM_001282293.1. [Q9NUT2-4]
# RefSeq	NP_009119	NM_007188.4. [Q9NUT2-2]
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule	PRU00441}. 
# SIMILARITY	Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA
# SUBCELLULAR LOCATION	ABCB8_HUMAN	Mitochondrion inner membrane {ECO 0000269|PubMed 16259955}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00441, ECO 0000269|PubMed 16259955}. 
# SUBUNIT	Monomer. {ECO	0000305}. 
# SUPFAM	SSF52540	SSF52540
# SUPFAM	SSF90123	SSF90123
# TCDB	3.A.1.201.22	the atp-binding cassette (abc) superfamily
# TISSUE SPECIFICITY	ABCB8_HUMAN	Ubiquitous. 
# UCSC	uc003wik	human. [Q9NUT2-1]
# WEB RESOURCE	ABCB8_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=Q9NUT2";
# eggNOG	COG1132	LUCA
# eggNOG	KOG0058	Eukaryota
BLAST	swissprot:ABCB8_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCB8_HUMAN
BioCyc	ZFISH:G66-30982-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-30982-MONOMER
COXPRESdb	11194	http://coxpresdb.jp/data/gene/11194.shtml
CleanEx	HS_ABCB8	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCB8
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/jmbi.1998.2259	http://dx.doi.org/10.1006/jmbi.1998.2259
DOI	10.1007/s10038-002-8653-6	http://dx.doi.org/10.1007/s10038-002-8653-6
DOI	10.1016/j.bbrc.2005.10.070	http://dx.doi.org/10.1016/j.bbrc.2005.10.070
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DrugBank	DB00997	http://www.drugbank.ca/drugs/DB00997
EMBL	AC010973	http://www.ebi.ac.uk/ena/data/view/AC010973
EMBL	AF047690	http://www.ebi.ac.uk/ena/data/view/AF047690
EMBL	AK002018	http://www.ebi.ac.uk/ena/data/view/AK002018
EMBL	AK024401	http://www.ebi.ac.uk/ena/data/view/AK024401
EMBL	AK222911	http://www.ebi.ac.uk/ena/data/view/AK222911
EMBL	AK294344	http://www.ebi.ac.uk/ena/data/view/AK294344
EMBL	AK314721	http://www.ebi.ac.uk/ena/data/view/AK314721
EMBL	BC141814	http://www.ebi.ac.uk/ena/data/view/BC141814
EMBL	BC141836	http://www.ebi.ac.uk/ena/data/view/BC141836
EMBL	BC151235	http://www.ebi.ac.uk/ena/data/view/BC151235
EMBL	CH471173	http://www.ebi.ac.uk/ena/data/view/CH471173
EMBL	CH471173	http://www.ebi.ac.uk/ena/data/view/CH471173
EMBL	CH471173	http://www.ebi.ac.uk/ena/data/view/CH471173
Ensembl	ENST00000297504	http://www.ensembl.org/id/ENST00000297504
Ensembl	ENST00000358849	http://www.ensembl.org/id/ENST00000358849
Ensembl	ENST00000498578	http://www.ensembl.org/id/ENST00000498578
Ensembl	ENST00000542328	http://www.ensembl.org/id/ENST00000542328
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005730
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005740	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005740
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0043190	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005730
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCB8	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCB8
GeneID	11194	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11194
GeneTree	ENSGT00550000074497	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074497
H-InvDB	HIX0007220	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0007220
HGNC	HGNC:49	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:49
HOVERGEN	HBG008358	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG008358&db=HOVERGEN
HPA	HPA045187	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA045187
InParanoid	Q9NUT2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NUT2
IntAct	Q9NUT2	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NUT2*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR011527	http://www.ebi.ac.uk/interpro/entry/IPR011527
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	11194	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=11194
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:11194	http://www.genome.jp/dbget-bin/www_bget?hsa:11194
KEGG_Orthology	KO:K05655	http://www.genome.jp/dbget-bin/www_bget?KO:K05655
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
MIM	605464	http://www.ncbi.nlm.nih.gov/omim/605464
MINT	MINT-1381060	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1381060
OMA	RSWWAGH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RSWWAGH
OrthoDB	EOG091G0HVA	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0HVA
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PROSITE	PS50929	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929
PSORT	swissprot:ABCB8_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCB8_HUMAN
PSORT-B	swissprot:ABCB8_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCB8_HUMAN
PSORT2	swissprot:ABCB8_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCB8_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF00664	http://pfam.xfam.org/family/PF00664
PharmGKB	PA24390	http://www.pharmgkb.org/do/serve?objId=PA24390&objCls=Gene
Phobius	swissprot:ABCB8_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCB8_HUMAN
PhylomeDB	Q9NUT2	http://phylomedb.org/?seqid=Q9NUT2
ProteinModelPortal	Q9NUT2	http://www.proteinmodelportal.org/query/uniprot/Q9NUT2
PubMed	11829140	http://www.ncbi.nlm.nih.gov/pubmed/11829140
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16259955	http://www.ncbi.nlm.nih.gov/pubmed/16259955
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	9878413	http://www.ncbi.nlm.nih.gov/pubmed/9878413
Reactome	R-HSA-1369007	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1369007
RefSeq	NP_001269220	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269220
RefSeq	NP_001269221	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269221
RefSeq	NP_001269222	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269222
RefSeq	NP_009119	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_009119
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	Q9NUT2	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9NUT2
STRING	9606.ENSP00000351717	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000351717&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
SUPFAM	SSF90123	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123
TCDB	3.A.1.201.22	http://www.tcdb.org/search/result.php?tc=3.A.1.201.22
UCSC	uc003wik	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003wik&org=rat
UniGene	Hs.647118	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.647118
UniProtKB	ABCB8_HUMAN	http://www.uniprot.org/uniprot/ABCB8_HUMAN
UniProtKB-AC	Q9NUT2	http://www.uniprot.org/uniprot/Q9NUT2
charge	swissprot:ABCB8_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCB8_HUMAN
eggNOG	COG1132	http://eggnogapi.embl.de/nog_data/html/tree/COG1132
eggNOG	KOG0058	http://eggnogapi.embl.de/nog_data/html/tree/KOG0058
epestfind	swissprot:ABCB8_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCB8_HUMAN
garnier	swissprot:ABCB8_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCB8_HUMAN
helixturnhelix	swissprot:ABCB8_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCB8_HUMAN
hmoment	swissprot:ABCB8_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCB8_HUMAN
iep	swissprot:ABCB8_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCB8_HUMAN
inforesidue	swissprot:ABCB8_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCB8_HUMAN
neXtProt	NX_Q9NUT2	http://www.nextprot.org/db/entry/NX_Q9NUT2
octanol	swissprot:ABCB8_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCB8_HUMAN
pepcoil	swissprot:ABCB8_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCB8_HUMAN
pepdigest	swissprot:ABCB8_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCB8_HUMAN
pepinfo	swissprot:ABCB8_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCB8_HUMAN
pepnet	swissprot:ABCB8_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCB8_HUMAN
pepstats	swissprot:ABCB8_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCB8_HUMAN
pepwheel	swissprot:ABCB8_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCB8_HUMAN
pepwindow	swissprot:ABCB8_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCB8_HUMAN
sigcleave	swissprot:ABCB8_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCB8_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	IMB1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14974-1; Sequence=Displayed; Name=2; IsoId=Q14974-2; Sequence=VSP_054612; Note=No experimental confirmation available.; 
# AltName	IMB1_HUMAN	Importin-90
# AltName	IMB1_HUMAN	Karyopherin subunit beta-1
# AltName	IMB1_HUMAN	Nuclear factor p97
# AltName	IMB1_HUMAN	Pore targeting complex 97 kDa subunit
# BioGrid	110035	242
# CCDS	CCDS11513	-. [Q14974-1]
# CCDS	CCDS62228	-. [Q14974-2]
# ChiTaRS	KPNB1	human
# Ensembl	ENST00000290158	ENSP00000290158; ENSG00000108424. [Q14974-1]
# Ensembl	ENST00000535458	ENSP00000438253; ENSG00000108424. [Q14974-2]
# Ensembl	ENST00000540627	ENSP00000438964; ENSG00000108424. [Q14974-2]
# ExpressionAtlas	Q14974	baseline and differential
# FUNCTION	IMB1_HUMAN	Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re- exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus. {ECO 0000269|PubMed 10228156, ECO 0000269|PubMed 11891849, ECO 0000269|PubMed 19386897, ECO 0000269|PubMed 24699649, ECO 0000269|PubMed 9687515}. 
# GO_component	GO:0005635	nuclear envelope; IDA:UniProtKB.
# GO_component	GO:0005643	nuclear pore; TAS:ProtInc.
# GO_component	GO:0005654	nucleoplasm; IDA:HPA.
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0031965	nuclear membrane; IDA:HPA.
# GO_component	GO:0034399	nuclear periphery; IBA:GO_Central.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_component	GO:0071782	endoplasmic reticulum tubular network; IDA:UniProtKB.
# GO_function	GO:0008139	nuclear localization sequence binding; TAS:ProtInc.
# GO_function	GO:0008270	zinc ion binding; TAS:ProtInc.
# GO_function	GO:0008565	protein transporter activity; IBA:GO_Central.
# GO_function	GO:0019899	enzyme binding; IPI:UniProtKB.
# GO_function	GO:0019904	protein domain specific binding; IPI:UniProtKB.
# GO_function	GO:0044822	poly(A) RNA binding; IDA:UniProtKB.
# GO_process	GO:0000059	protein import into nucleus, docking; IBA:GO_Central.
# GO_process	GO:0000060	protein import into nucleus, translocation; TAS:ProtInc.
# GO_process	GO:0006309	apoptotic DNA fragmentation; TAS:Reactome.
# GO_process	GO:0006606	protein import into nucleus; IDA:MGI.
# GO_process	GO:0006607	NLS-bearing protein import into nucleus; TAS:ProtInc.
# GO_process	GO:0006610	ribosomal protein import into nucleus; IDA:UniProtKB.
# GO_process	GO:0007079	mitotic chromosome movement towards spindle pole; IMP:UniProtKB.
# GO_process	GO:0007080	mitotic metaphase plate congression; IMP:UniProtKB.
# GO_process	GO:0019054	modulation by virus of host process; TAS:Reactome.
# GO_process	GO:0030953	astral microtubule organization; IMP:UniProtKB.
# GO_process	GO:0031291	Ran protein signal transduction; IMP:UniProtKB.
# GO_process	GO:0040001	establishment of mitotic spindle localization; IMP:UniProtKB.
# GO_process	GO:0045184	establishment of protein localization; IMP:UniProtKB.
# GO_process	GO:0075733	intracellular transport of virus; TAS:Reactome.
# GO_process	GO:0090307	mitotic spindle assembly; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005635	nuclear envelope
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0003723	RNA binding
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006259	DNA metabolic process
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# GOslim_process	GO:0007010	cytoskeleton organization
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0022607	cellular component assembly
# GOslim_process	GO:0034655	nucleobase-containing compound catabolic process
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# Gene3D	1.25.10.10	-; 1.
# Genevisible	Q14974	HS
# HGNC	HGNC:6400	KPNB1
# INTERACTION	IMB1_HUMAN	Q9WMX2 - (xeno); NbExp=2; IntAct=EBI-286758, EBI-710918; P04626 ERBB2; NbExp=14; IntAct=EBI-286758, EBI-641062; P03101 L1 (xeno); NbExp=2; IntAct=EBI-286758, EBI-7362698; P03107 L2 (xeno); NbExp=2; IntAct=EBI-286758, EBI-7362531; Q8K4J6 Mkl1 (xeno); NbExp=5; IntAct=EBI-286758, EBI-8291665; P14907 NSP1 (xeno); NbExp=2; IntAct=EBI-286758, EBI-12265; P49790 NUP153; NbExp=3; IntAct=EBI-286758, EBI-286779; P04620 rev (xeno); NbExp=3; IntAct=EBI-286758, EBI-10687101; Q16637-3 SMN2; NbExp=5; IntAct=EBI-286758, EBI-395447; O75940 SMNDC1; NbExp=2; IntAct=EBI-286758, EBI-1052641; 
# IntAct	Q14974	146
# InterPro	IPR000225	Armadillo
# InterPro	IPR001494	Importin-beta_N
# InterPro	IPR011989	ARM-like
# InterPro	IPR016024	ARM-type_fold
# InterPro	IPR021133	HEAT_type_2
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko03036	 Chromosome
# KEGG_Pathway	ko03013	RNA transport
# MIM	602738	gene
# Organism	IMB1_HUMAN	Homo sapiens (Human)
# PDB	1F59	X-ray; 2.80 A; A/B=1-442
# PDB	1IBR	X-ray; 2.30 A; B/D=1-462
# PDB	1M5N	X-ray; 2.90 A; S=1-485
# PDB	1O6O	X-ray; 2.80 A; A/B/C=1-442
# PDB	1O6P	X-ray; 2.80 A; A/B=1-442
# PDB	1QGK	X-ray; 2.50 A; A=1-876
# PDB	1QGR	X-ray; 2.30 A; A=1-876
# PDB	2P8Q	X-ray; 2.35 A; A=1-876
# PDB	2Q5D	X-ray; 3.20 A; A/B=1-876
# PDB	2QNA	X-ray; 2.84 A; A=127-875
# PDB	3LWW	X-ray; 3.15 A; A/C=1-876
# PDB	3W5K	X-ray; 2.60 A; A=1-876
# PIR	I52907	I52907
# PROSITE	PS50077	HEAT_REPEAT
# PROSITE	PS50166	IMPORTIN_B_NT
# PTM	IMB1_HUMAN	Mono-ADP-ribosylated by PARP16. 
# Pfam	PF03810	IBN_N
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-1169408	ISG15 antiviral mechanism
# Reactome	R-HSA-1655829	Regulation of cholesterol biosynthesis by SREBP (SREBF)
# Reactome	R-HSA-168271	Transport of Ribonucleoproteins into the Host Nucleus
# Reactome	R-HSA-168276	NS1 Mediated Effects on Host Pathways
# Reactome	R-HSA-180746	Nuclear import of Rev protein
# Reactome	R-HSA-211227	Activation of DNA fragmentation factor
# Reactome	R-HSA-6798695	Neutrophil degranulation
# RecName	IMB1_HUMAN	Importin subunit beta-1
# RefSeq	NP_001263382	NM_001276453.1. [Q14974-2]
# RefSeq	NP_002256	NM_002265.5. [Q14974-1]
# SIMILARITY	Belongs to the importin beta family. Importin beta-1 subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 importin N-terminal domain. {ECO:0000255|PROSITE-ProRule	PRU00115}.
# SIMILARITY	Contains 19 HEAT repeats. {ECO:0000269|PubMed	10353244}. 
# SMART	SM00185	ARM; 3
# SMART	SM00913	IBN_N
# SUBCELLULAR LOCATION	IMB1_HUMAN	Cytoplasm {ECO 0000269|PubMed 11891849}. Nucleus envelope {ECO 0000269|PubMed 11891849}. 
# SUBUNIT	IMB1_HUMAN	Forms a complex with an importin alpha subunit. Forms a heterodimer with IPO7. Interacts with IPO7, SNUPN, RPL23A and XPO1. The KPNB1/IPO7 heterodimer interacts with H1 histone. Interacts with H2A, H2B, H3 and H4 histones (By similarity). Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN and XPO1. Binds to HIV-1 Rev and Tat. Interacts with HTLV-1 Rex. Interacts with SRY. Interacts with PRKCI/atypical protein kinase C iota. Interacts with human respiratory syncytial virus (HRSV) protein M. Interacts with KPNA7. Interacts with SNAI1 (via zinc fingers) and SNAI2 (via zinc fingers). Interacts with SLC35G1 and STIM1. Interacts with DCAF8. Interacts with RAN (By similarity). {ECO 0000250|UniProtKB P70168, ECO 0000269|PubMed 10209022, ECO 0000269|PubMed 10228156, ECO 0000269|PubMed 11891849, ECO 0000269|PubMed 12095920, ECO 0000269|PubMed 12764225, ECO 0000269|PubMed 15297880, ECO 0000269|PubMed 15629770, ECO 0000269|PubMed 15836774, ECO 0000269|PubMed 16171404, ECO 0000269|PubMed 16704975, ECO 0000269|PubMed 19386897, ECO 0000269|PubMed 20701745, ECO 0000269|PubMed 22084111, ECO 0000269|PubMed 22500989, ECO 0000269|PubMed 22701565, ECO 0000269|PubMed 24699649, ECO 0000269|PubMed 8617227, ECO 0000269|PubMed 9405152, ECO 0000269|PubMed 9670026, ECO 0000269|PubMed 9687515, ECO 0000269|PubMed 9891055, ECO 0000269|PubMed 9891056}. 
# SUPFAM	SSF48371	SSF48371
# TCDB	1.I.1.1	the nuclear pore complex (npc) family
# TopDownProteomics	Q14974-1	-. [Q14974-1]
# UCSC	uc002ilt	human. [Q14974-1]
# eggNOG	COG5215	LUCA
# eggNOG	KOG1241	Eukaryota
BLAST	swissprot:IMB1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:IMB1_HUMAN
BioCyc	ZFISH:ENSG00000108424-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000108424-MONOMER
COXPRESdb	3837	http://coxpresdb.jp/data/gene/3837.shtml
CleanEx	HS_KPNB1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KPNB1
DIP	DIP-6204N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-6204N
DOI	10.1002/jcb.10101.abs	http://dx.doi.org/10.1002/jcb.10101.abs
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/jmbi.1997.1420	http://dx.doi.org/10.1006/jmbi.1997.1420
DOI	10.1016/S0092-8674(00)00014-3	http://dx.doi.org/10.1016/S0092-8674(00)00014-3
DOI	10.1016/S0092-8674(00)80774-6	http://dx.doi.org/10.1016/S0092-8674(00)80774-6
DOI	10.1016/S0960-9822(95)00079-0	http://dx.doi.org/10.1016/S0960-9822(95)00079-0
DOI	10.1016/S1097-2765(02)00727-X	http://dx.doi.org/10.1016/S1097-2765(02)00727-X
DOI	10.1016/j.febslet.2012.02.053	http://dx.doi.org/10.1016/j.febslet.2012.02.053
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1016/j.virol.2004.10.031	http://dx.doi.org/10.1016/j.virol.2004.10.031
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/bi050701e	http://dx.doi.org/10.1021/bi050701e
DOI	10.1021/bi100292y	http://dx.doi.org/10.1021/bi100292y
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/20367	http://dx.doi.org/10.1038/20367
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.emboj.7600352	http://dx.doi.org/10.1038/sj.emboj.7600352
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.1117231108	http://dx.doi.org/10.1073/pnas.1117231108
DOI	10.1073/pnas.1137864100	http://dx.doi.org/10.1073/pnas.1137864100
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1073/pnas.93.14.7059	http://dx.doi.org/10.1073/pnas.93.14.7059
DOI	10.1074/jbc.M602189200	http://dx.doi.org/10.1074/jbc.M602189200
DOI	10.1074/jbc.M709093200	http://dx.doi.org/10.1074/jbc.M709093200
DOI	10.1074/mcp.M111.015131	http://dx.doi.org/10.1074/mcp.M111.015131
DOI	10.1083/jcb.130.2.265	http://dx.doi.org/10.1083/jcb.130.2.265
DOI	10.1083/jcb.145.2.255	http://dx.doi.org/10.1083/jcb.145.2.255
DOI	10.1093/emboj/17.14.4114	http://dx.doi.org/10.1093/emboj/17.14.4114
DOI	10.1093/emboj/17.15.4491	http://dx.doi.org/10.1093/emboj/17.15.4491
DOI	10.1093/emboj/18.9.2411	http://dx.doi.org/10.1093/emboj/18.9.2411
DOI	10.1093/hmg/11.15.1785	http://dx.doi.org/10.1093/hmg/11.15.1785
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1107/S1399004714000972	http://dx.doi.org/10.1107/S1399004714000972
DOI	10.1111/j.1365-2443.2005.00850.x	http://dx.doi.org/10.1111/j.1365-2443.2005.00850.x
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1128/MCB.19.2.1210	http://dx.doi.org/10.1128/MCB.19.2.1210
DOI	10.1128/MCB.19.2.1218	http://dx.doi.org/10.1128/MCB.19.2.1218
DOI	10.1186/1471-2121-11-63	http://dx.doi.org/10.1186/1471-2121-11-63
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1242/jcs.041749	http://dx.doi.org/10.1242/jcs.041749
DOI	10.1371/journal.pone.0037352	http://dx.doi.org/10.1371/journal.pone.0037352
EMBL	AC015674	http://www.ebi.ac.uk/ena/data/view/AC015674
EMBL	AC025682	http://www.ebi.ac.uk/ena/data/view/AC025682
EMBL	AK316421	http://www.ebi.ac.uk/ena/data/view/AK316421
EMBL	BC003572	http://www.ebi.ac.uk/ena/data/view/BC003572
EMBL	BC024045	http://www.ebi.ac.uk/ena/data/view/BC024045
EMBL	BC036703	http://www.ebi.ac.uk/ena/data/view/BC036703
EMBL	BT009797	http://www.ebi.ac.uk/ena/data/view/BT009797
EMBL	CH471109	http://www.ebi.ac.uk/ena/data/view/CH471109
EMBL	CH471109	http://www.ebi.ac.uk/ena/data/view/CH471109
EMBL	CH471109	http://www.ebi.ac.uk/ena/data/view/CH471109
EMBL	L38951	http://www.ebi.ac.uk/ena/data/view/L38951
EMBL	L39793	http://www.ebi.ac.uk/ena/data/view/L39793
Ensembl	ENST00000290158	http://www.ensembl.org/id/ENST00000290158
Ensembl	ENST00000535458	http://www.ensembl.org/id/ENST00000535458
Ensembl	ENST00000540627	http://www.ensembl.org/id/ENST00000540627
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GO_component	GO:0005643	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005643
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0031965	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031965
GO_component	GO:0034399	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034399
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_component	GO:0071782	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071782
GO_function	GO:0008139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008139
GO_function	GO:0008270	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GO_function	GO:0019904	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019904
GO_function	GO:0044822	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044822
GO_process	GO:0000059	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000059
GO_process	GO:0000060	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000060
GO_process	GO:0006309	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006309
GO_process	GO:0006606	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006606
GO_process	GO:0006607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006607
GO_process	GO:0006610	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006610
GO_process	GO:0007079	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007079
GO_process	GO:0007080	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007080
GO_process	GO:0019054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019054
GO_process	GO:0030953	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030953
GO_process	GO:0031291	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031291
GO_process	GO:0040001	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040001
GO_process	GO:0045184	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045184
GO_process	GO:0075733	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0075733
GO_process	GO:0090307	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090307
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0003723	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006259	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
GOslim_process	GO:0007010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007010
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0022607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607
GOslim_process	GO:0034655	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
GeneCards	KPNB1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KPNB1
GeneID	3837	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3837
GeneTree	ENSGT00550000074898	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074898
HGNC	HGNC:6400	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6400
HOGENOM	HOG000204108	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000204108&db=HOGENOM6
HOVERGEN	HBG002369	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG002369&db=HOVERGEN
HPA	CAB034449	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB034449
HPA	HPA029878	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA029878
HPA	HPA050302	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA050302
InParanoid	Q14974	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q14974
IntAct	Q14974	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q14974*
InterPro	IPR000225	http://www.ebi.ac.uk/interpro/entry/IPR000225
InterPro	IPR001494	http://www.ebi.ac.uk/interpro/entry/IPR001494
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
InterPro	IPR021133	http://www.ebi.ac.uk/interpro/entry/IPR021133
Jabion	3837	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3837
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko03036	http://www.genome.jp/dbget-bin/www_bget?ko03036
KEGG_Gene	hsa:3837	http://www.genome.jp/dbget-bin/www_bget?hsa:3837
KEGG_Orthology	KO:K14293	http://www.genome.jp/dbget-bin/www_bget?KO:K14293
KEGG_Pathway	ko03013	http://www.genome.jp/kegg-bin/show_pathway?ko03013
MIM	602738	http://www.ncbi.nlm.nih.gov/omim/602738
MINT	MINT-94095	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-94095
OMA	MSNILPY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MSNILPY
OrthoDB	EOG091G01XQ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01XQ
PDB	1F59	http://www.ebi.ac.uk/pdbe-srv/view/entry/1F59
PDB	1IBR	http://www.ebi.ac.uk/pdbe-srv/view/entry/1IBR
PDB	1M5N	http://www.ebi.ac.uk/pdbe-srv/view/entry/1M5N
PDB	1O6O	http://www.ebi.ac.uk/pdbe-srv/view/entry/1O6O
PDB	1O6P	http://www.ebi.ac.uk/pdbe-srv/view/entry/1O6P
PDB	1QGK	http://www.ebi.ac.uk/pdbe-srv/view/entry/1QGK
PDB	1QGR	http://www.ebi.ac.uk/pdbe-srv/view/entry/1QGR
PDB	2P8Q	http://www.ebi.ac.uk/pdbe-srv/view/entry/2P8Q
PDB	2Q5D	http://www.ebi.ac.uk/pdbe-srv/view/entry/2Q5D
PDB	2QNA	http://www.ebi.ac.uk/pdbe-srv/view/entry/2QNA
PDB	3LWW	http://www.ebi.ac.uk/pdbe-srv/view/entry/3LWW
PDB	3W5K	http://www.ebi.ac.uk/pdbe-srv/view/entry/3W5K
PDBsum	1F59	http://www.ebi.ac.uk/pdbsum/1F59
PDBsum	1IBR	http://www.ebi.ac.uk/pdbsum/1IBR
PDBsum	1M5N	http://www.ebi.ac.uk/pdbsum/1M5N
PDBsum	1O6O	http://www.ebi.ac.uk/pdbsum/1O6O
PDBsum	1O6P	http://www.ebi.ac.uk/pdbsum/1O6P
PDBsum	1QGK	http://www.ebi.ac.uk/pdbsum/1QGK
PDBsum	1QGR	http://www.ebi.ac.uk/pdbsum/1QGR
PDBsum	2P8Q	http://www.ebi.ac.uk/pdbsum/2P8Q
PDBsum	2Q5D	http://www.ebi.ac.uk/pdbsum/2Q5D
PDBsum	2QNA	http://www.ebi.ac.uk/pdbsum/2QNA
PDBsum	3LWW	http://www.ebi.ac.uk/pdbsum/3LWW
PDBsum	3W5K	http://www.ebi.ac.uk/pdbsum/3W5K
PROSITE	PS50077	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50077
PROSITE	PS50166	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50166
PSORT	swissprot:IMB1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:IMB1_HUMAN
PSORT-B	swissprot:IMB1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:IMB1_HUMAN
PSORT2	swissprot:IMB1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:IMB1_HUMAN
Pfam	PF03810	http://pfam.xfam.org/family/PF03810
PharmGKB	PA30191	http://www.pharmgkb.org/do/serve?objId=PA30191&objCls=Gene
Phobius	swissprot:IMB1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:IMB1_HUMAN
PhylomeDB	Q14974	http://phylomedb.org/?seqid=Q14974
ProteinModelPortal	Q14974	http://www.proteinmodelportal.org/query/uniprot/Q14974
PubMed	10209022	http://www.ncbi.nlm.nih.gov/pubmed/10209022
PubMed	10228156	http://www.ncbi.nlm.nih.gov/pubmed/10228156
PubMed	10353244	http://www.ncbi.nlm.nih.gov/pubmed/10353244
PubMed	10367892	http://www.ncbi.nlm.nih.gov/pubmed/10367892
PubMed	10929717	http://www.ncbi.nlm.nih.gov/pubmed/10929717
PubMed	11891849	http://www.ncbi.nlm.nih.gov/pubmed/11891849
PubMed	12095920	http://www.ncbi.nlm.nih.gov/pubmed/12095920
PubMed	12504010	http://www.ncbi.nlm.nih.gov/pubmed/12504010
PubMed	12764225	http://www.ncbi.nlm.nih.gov/pubmed/12764225
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15297880	http://www.ncbi.nlm.nih.gov/pubmed/15297880
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15629770	http://www.ncbi.nlm.nih.gov/pubmed/15629770
PubMed	15836774	http://www.ncbi.nlm.nih.gov/pubmed/15836774
PubMed	16171404	http://www.ncbi.nlm.nih.gov/pubmed/16171404
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	16704975	http://www.ncbi.nlm.nih.gov/pubmed/16704975
PubMed	18187419	http://www.ncbi.nlm.nih.gov/pubmed/18187419
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	19386897	http://www.ncbi.nlm.nih.gov/pubmed/19386897
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	20476751	http://www.ncbi.nlm.nih.gov/pubmed/20476751
PubMed	20701745	http://www.ncbi.nlm.nih.gov/pubmed/20701745
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22084111	http://www.ncbi.nlm.nih.gov/pubmed/22084111
PubMed	22223895	http://www.ncbi.nlm.nih.gov/pubmed/22223895
PubMed	22500989	http://www.ncbi.nlm.nih.gov/pubmed/22500989
PubMed	22701565	http://www.ncbi.nlm.nih.gov/pubmed/22701565
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	24699649	http://www.ncbi.nlm.nih.gov/pubmed/24699649
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	7615630	http://www.ncbi.nlm.nih.gov/pubmed/7615630
PubMed	7627554	http://www.ncbi.nlm.nih.gov/pubmed/7627554
PubMed	8617227	http://www.ncbi.nlm.nih.gov/pubmed/8617227
PubMed	8692944	http://www.ncbi.nlm.nih.gov/pubmed/8692944
PubMed	9405152	http://www.ncbi.nlm.nih.gov/pubmed/9405152
PubMed	9670026	http://www.ncbi.nlm.nih.gov/pubmed/9670026
PubMed	9687515	http://www.ncbi.nlm.nih.gov/pubmed/9687515
PubMed	9891055	http://www.ncbi.nlm.nih.gov/pubmed/9891055
PubMed	9891056	http://www.ncbi.nlm.nih.gov/pubmed/9891056
Reactome	R-HSA-1169408	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1169408
Reactome	R-HSA-1655829	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1655829
Reactome	R-HSA-168271	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-168271
Reactome	R-HSA-168276	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-168276
Reactome	R-HSA-180746	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-180746
Reactome	R-HSA-211227	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-211227
Reactome	R-HSA-6798695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6798695
RefSeq	NP_001263382	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001263382
RefSeq	NP_002256	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002256
SMART	SM00185	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00185
SMART	SM00913	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00913
SMR	Q14974	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q14974
STRING	9606.ENSP00000290158	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000290158&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
TCDB	1.I.1.1	http://www.tcdb.org/search/result.php?tc=1.I.1.1
UCSC	uc002ilt	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ilt&org=rat
UniGene	Hs.532793	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.532793
UniProtKB	IMB1_HUMAN	http://www.uniprot.org/uniprot/IMB1_HUMAN
UniProtKB-AC	Q14974	http://www.uniprot.org/uniprot/Q14974
charge	swissprot:IMB1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:IMB1_HUMAN
eggNOG	COG5215	http://eggnogapi.embl.de/nog_data/html/tree/COG5215
eggNOG	KOG1241	http://eggnogapi.embl.de/nog_data/html/tree/KOG1241
epestfind	swissprot:IMB1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:IMB1_HUMAN
garnier	swissprot:IMB1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:IMB1_HUMAN
helixturnhelix	swissprot:IMB1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:IMB1_HUMAN
hmoment	swissprot:IMB1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:IMB1_HUMAN
iep	swissprot:IMB1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:IMB1_HUMAN
inforesidue	swissprot:IMB1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:IMB1_HUMAN
neXtProt	NX_Q14974	http://www.nextprot.org/db/entry/NX_Q14974
octanol	swissprot:IMB1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:IMB1_HUMAN
pepcoil	swissprot:IMB1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:IMB1_HUMAN
pepdigest	swissprot:IMB1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:IMB1_HUMAN
pepinfo	swissprot:IMB1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:IMB1_HUMAN
pepnet	swissprot:IMB1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:IMB1_HUMAN
pepstats	swissprot:IMB1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:IMB1_HUMAN
pepwheel	swissprot:IMB1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:IMB1_HUMAN
pepwindow	swissprot:IMB1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:IMB1_HUMAN
sigcleave	swissprot:IMB1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:IMB1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S22A2_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O15244-1; Sequence=Displayed; Name=2; Synonyms=OCT2-A; IsoId=O15244-2; Sequence=VSP_031773, VSP_031774; Name=3; IsoId=O15244-3; Sequence=VSP_031771, VSP_031772; Note=No experimental confirmation available.; 
# AltName	S22A2_HUMAN	Organic cation transporter 2
# BIOPHYSICOCHEMICAL PROPERTIES	S22A2_HUMAN	Kinetic parameters  KM=1 mM for agmatine {ECO 0000269|PubMed 11758759, ECO 0000269|PubMed 12089365, ECO 0000269|PubMed 12538837, ECO 0000269|PubMed 15783073, ECO 0000269|PubMed 16006492, ECO 0000269|PubMed 16272756, ECO 0000269|PubMed 16394027, ECO 0000269|PubMed 9687576}; KM=95 uM for amiloride {ECO 0000269|PubMed 11758759, ECO 0000269|PubMed 12089365, ECO 0000269|PubMed 12538837, ECO 0000269|PubMed 15783073, ECO 0000269|PubMed 16006492, ECO 0000269|PubMed 16272756, ECO 0000269|PubMed 16394027, ECO 0000269|PubMed 9687576}; KM=24 uM for ASP {ECO 0000269|PubMed 11758759, ECO 0000269|PubMed 12089365, ECO 0000269|PubMed 12538837, ECO 0000269|PubMed 15783073, ECO 0000269|PubMed 16006492, ECO 0000269|PubMed 16272756, ECO 0000269|PubMed 16394027, ECO 0000269|PubMed 9687576}; KM=34 uM for memantine {ECO 0000269|PubMed 11758759, ECO 0000269|PubMed 12089365, ECO 0000269|PubMed 12538837, ECO 0000269|PubMed 15783073, ECO 0000269|PubMed 16006492, ECO 0000269|PubMed 16272756, ECO 0000269|PubMed 16394027, ECO 0000269|PubMed 9687576}; KM=27 uM for amantadine {ECO 0000269|PubMed 11758759, ECO 0000269|PubMed 12089365, ECO 0000269|PubMed 12538837, ECO 0000269|PubMed 15783073, ECO 0000269|PubMed 16006492, ECO 0000269|PubMed 16272756, ECO 0000269|PubMed 16394027, ECO 0000269|PubMed 9687576}; KM=1.38 mM for metformin {ECO 0000269|PubMed 11758759, ECO 0000269|PubMed 12089365, ECO 0000269|PubMed 12538837, ECO 0000269|PubMed 15783073, ECO 0000269|PubMed 16006492, ECO 0000269|PubMed 16272756, ECO 0000269|PubMed 16394027, ECO 0000269|PubMed 9687576}; KM=1.9 mM for noradrenaline {ECO 0000269|PubMed 11758759, ECO 0000269|PubMed 12089365, ECO 0000269|PubMed 12538837, ECO 0000269|PubMed 15783073, ECO 0000269|PubMed 16006492, ECO 0000269|PubMed 16272756, ECO 0000269|PubMed 16394027, ECO 0000269|PubMed 9687576}; KM=1.9 mM for norepinephrine {ECO 0000269|PubMed 11758759, ECO 0000269|PubMed 12089365, ECO 0000269|PubMed 12538837, ECO 0000269|PubMed 15783073, ECO 0000269|PubMed 16006492, ECO 0000269|PubMed 16272756, ECO 0000269|PubMed 16394027, ECO 0000269|PubMed 9687576}; KM=1.3 mM for histamine {ECO 0000269|PubMed 11758759, ECO 0000269|PubMed 12089365, ECO 0000269|PubMed 12538837, ECO 0000269|PubMed 15783073, ECO 0000269|PubMed 16006492, ECO 0000269|PubMed 16272756, ECO 0000269|PubMed 16394027, ECO 0000269|PubMed 9687576}; KM=0.39 mM for dopamine {ECO 0000269|PubMed 11758759, ECO 0000269|PubMed 12089365, ECO 0000269|PubMed 12538837, ECO 0000269|PubMed 15783073, ECO 0000269|PubMed 16006492, ECO 0000269|PubMed 16272756, ECO 0000269|PubMed 16394027, ECO 0000269|PubMed 9687576}; KM=0.08 mM for serotonine {ECO 0000269|PubMed 11758759, ECO 0000269|PubMed 12089365, ECO 0000269|PubMed 12538837, ECO 0000269|PubMed 15783073, ECO 0000269|PubMed 16006492, ECO 0000269|PubMed 16272756, ECO 0000269|PubMed 16394027, ECO 0000269|PubMed 9687576}; KM=72.6 uM for cimetidine (at pH 7.4 and 37 degrees Celsius) {ECO 0000269|PubMed 11758759, ECO 0000269|PubMed 12089365, ECO 0000269|PubMed 12538837, ECO 0000269|PubMed 15783073, ECO 0000269|PubMed 16006492, ECO 0000269|PubMed 16272756, ECO 0000269|PubMed 16394027, ECO 0000269|PubMed 9687576}; KM=56.1 uM for famotidine {ECO 0000269|PubMed 11758759, ECO 0000269|PubMed 12089365, ECO 0000269|PubMed 12538837, ECO 0000269|PubMed 15783073, ECO 0000269|PubMed 16006492, ECO 0000269|PubMed 16272756, ECO 0000269|PubMed 16394027, ECO 0000269|PubMed 9687576}; KM=65.2 uM for ranitidine {ECO 0000269|PubMed 11758759, ECO 0000269|PubMed 12089365, ECO 0000269|PubMed 12538837, ECO 0000269|PubMed 15783073, ECO 0000269|PubMed 16006492, ECO 0000269|PubMed 16272756, ECO 0000269|PubMed 16394027, ECO 0000269|PubMed 9687576}; KM=431 uM for TEA (isoform 1) {ECO 0000269|PubMed 11758759, ECO 0000269|PubMed 12089365, ECO 0000269|PubMed 12538837, ECO 0000269|PubMed 15783073, ECO 0000269|PubMed 16006492, ECO 0000269|PubMed 16272756, ECO 0000269|PubMed 16394027, ECO 0000269|PubMed 9687576}; KM=63 uM for TEA (isoform 2) {ECO 0000269|PubMed 11758759, ECO 0000269|PubMed 12089365, ECO 0000269|PubMed 12538837, ECO 0000269|PubMed 15783073, ECO 0000269|PubMed 16006492, ECO 0000269|PubMed 16272756, ECO 0000269|PubMed 16394027, ECO 0000269|PubMed 9687576}; Vmax=3770 pmol/min/mg enzyme for TEA uptake (isoform 1) {ECO 0000269|PubMed 11758759, ECO 0000269|PubMed 12089365, ECO 0000269|PubMed 12538837, ECO 0000269|PubMed 15783073, ECO 0000269|PubMed 16006492, ECO 0000269|PubMed 16272756, ECO 0000269|PubMed 16394027, ECO 0000269|PubMed 9687576}; Vmax=314 pmol/min/mg enzyme for TEA uptake (isoform 2) {ECO 0000269|PubMed 11758759, ECO 0000269|PubMed 12089365, ECO 0000269|PubMed 12538837, ECO 0000269|PubMed 15783073, ECO 0000269|PubMed 16006492, ECO 0000269|PubMed 16272756, ECO 0000269|PubMed 16394027, ECO 0000269|PubMed 9687576}; Vmax=11.9 nmol/min/mg enzyme for metformin uptake {ECO 0000269|PubMed 11758759, ECO 0000269|PubMed 12089365, ECO 0000269|PubMed 12538837, ECO 0000269|PubMed 15783073, ECO 0000269|PubMed 16006492, ECO 0000269|PubMed 16272756, ECO 0000269|PubMed 16394027, ECO 0000269|PubMed 9687576}; Vmax=2170 pmol/min/mg enzyme for cimetidine uptake {ECO 0000269|PubMed 11758759, ECO 0000269|PubMed 12089365, ECO 0000269|PubMed 12538837, ECO 0000269|PubMed 15783073, ECO 0000269|PubMed 16006492, ECO 0000269|PubMed 16272756, ECO 0000269|PubMed 16394027, ECO 0000269|PubMed 9687576}; Vmax=204 pmol/min/mg enzyme for famotidine uptake {ECO 0000269|PubMed 11758759, ECO 0000269|PubMed 12089365, ECO 0000269|PubMed 12538837, ECO 0000269|PubMed 15783073, ECO 0000269|PubMed 16006492, ECO 0000269|PubMed 16272756, ECO 0000269|PubMed 16394027, ECO 0000269|PubMed 9687576}; Vmax=265 pmol/min/mg enzyme for ranitidine uptake {ECO 0000269|PubMed 11758759, ECO 0000269|PubMed 12089365, ECO 0000269|PubMed 12538837, ECO 0000269|PubMed 15783073, ECO 0000269|PubMed 16006492, ECO 0000269|PubMed 16272756, ECO 0000269|PubMed 16394027, ECO 0000269|PubMed 9687576}; 
# BioGrid	112469	8
# CCDS	CCDS5276	-. [O15244-1]
# CDD	cd06174	MFS
# DrugBank	DB00122	Choline
# DrugBank	DB00152	Thiamine
# DrugBank	DB00184	Nicotine
# DrugBank	DB00206	Reserpine
# DrugBank	DB00242	Cladribine
# DrugBank	DB00264	Metoprolol
# DrugBank	DB00280	Disopyramide
# DrugBank	DB00331	Metformin
# DrugBank	DB00345	Aminohippurate
# DrugBank	DB00368	Norepinephrine
# DrugBank	DB00396	Progesterone
# DrugBank	DB00413	Pramipexole
# DrugBank	DB00457	Prazosin
# DrugBank	DB00458	Imipramine
# DrugBank	DB00468	Quinine
# DrugBank	DB00495	Zidovudine
# DrugBank	DB00501	Cimetidine
# DrugBank	DB00515	Cisplatin
# DrugBank	DB00526	Oxaliplatin
# DrugBank	DB00536	Guanidine
# DrugBank	DB00570	Vinblastine
# DrugBank	DB00571	Propranolol
# DrugBank	DB00594	Amiloride
# DrugBank	DB00619	Imatinib
# DrugBank	DB00667	Histamine Phosphate
# DrugBank	DB00668	Epinephrine
# DrugBank	DB00690	Flurazepam
# DrugBank	DB00694	Daunorubicin
# DrugBank	DB00709	Lamivudine
# DrugBank	DB00783	Estradiol
# DrugBank	DB00907	Cocaine
# DrugBank	DB00908	Quinidine
# DrugBank	DB00914	Phenformin
# DrugBank	DB00915	Amantadine
# DrugBank	DB00917	Dinoprostone
# DrugBank	DB00925	Phenoxybenzamine
# DrugBank	DB00927	Famotidine
# DrugBank	DB00987	Cytarabine
# DrugBank	DB00988	Dopamine
# DrugBank	DB01032	Probenecid
# DrugBank	DB01035	Procainamide
# DrugBank	DB01043	Memantine
# DrugBank	DB01075	Diphenhydramine
# DrugBank	DB01103	Quinacrine
# DrugBank	DB01114	Chlorphenamine
# DrugBank	DB01137	Levofloxacin
# DrugBank	DB01151	Desipramine
# DrugBank	DB01160	Dinoprost Tromethamine
# DrugBank	DB01199	Tubocurarine
# DrugBank	DB01337	Pancuronium
# DrugBank	DB01580	Oxprenolol
# Ensembl	ENST00000366953	ENSP00000355920; ENSG00000112499. [O15244-1]
# ExpressionAtlas	O15244	baseline and differential
# FUNCTION	S22A2_HUMAN	Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity. {ECO 0000269|PubMed 12089365, ECO 0000269|PubMed 12538837, ECO 0000269|PubMed 15496291, ECO 0000269|PubMed 15783073, ECO 0000269|PubMed 16006492, ECO 0000269|PubMed 16272756, ECO 0000269|PubMed 16314463, ECO 0000269|PubMed 16394027, ECO 0000269|PubMed 16914559, ECO 0000269|PubMed 16951202, ECO 0000269|PubMed 17072098, ECO 0000269|PubMed 17582384, ECO 0000269|PubMed 9260930, ECO 0000269|PubMed 9687576}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_component	GO:0098793	presynapse; IEA:GOC.
# GO_function	GO:0005326	neurotransmitter transporter activity; TAS:Reactome.
# GO_function	GO:0005329	dopamine transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015101	organic cation transmembrane transporter activity; IDA:MGI.
# GO_function	GO:0015220	choline transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015651	quaternary ammonium group transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0006855	drug transmembrane transport; TAS:Reactome.
# GO_process	GO:0007269	neurotransmitter secretion; TAS:Reactome.
# GO_process	GO:0007589	body fluid secretion; TAS:ProtInc.
# GO_process	GO:0015695	organic cation transport; IDA:MGI.
# GO_process	GO:0015871	choline transport; IBA:GO_Central.
# GO_process	GO:0015872	dopamine transport; IBA:GO_Central.
# GO_process	GO:0042136	neurotransmitter biosynthetic process; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	O15244	HS
# HGNC	HGNC:10966	SLC22A2
# INDUCTION	May be down-regulated in diabetic patients. {ECO:0000269|PubMed	16314463}. 
# IntAct	O15244	8
# InterPro	IPR004749	Orgcat_transp/SVOP
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR005829	Sugar_transporter_CS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	602608	gene
# Organism	S22A2_HUMAN	Homo sapiens (Human)
# PROSITE	PS00216	SUGAR_TRANSPORT_1; 2
# PROSITE	PS50850	MFS
# Pfam	PF00083	Sugar_tr
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-112311	Neurotransmitter Clearance In The Synaptic Cleft
# Reactome	R-HSA-181430	Norepinephrine Neurotransmitter Release Cycle
# Reactome	R-HSA-2161517	Abacavir transmembrane transport
# Reactome	R-HSA-442660	Na+/Cl- dependent neurotransmitter transporters
# Reactome	R-HSA-549127	Organic cation transport
# RecName	S22A2_HUMAN	Solute carrier family 22 member 2
# RefSeq	NP_003049	NM_003058.3. [O15244-1]
# SIMILARITY	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S22A2_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.19.30	the major facilitator superfamily (mfs)
# TIGRFAMs	TIGR00898	2A0119
# TISSUE SPECIFICITY	S22A2_HUMAN	Mainly expressed in kidney. Localized at the luminal membrane and basolateral membrane of kidney distal tubule and proximal tubules. To a lower extent, expressed in neurons of the cerebral cortex and in various subcortical nuclei (at protein levels). Also detected in secretory phase endometrium; in scattered cells in the stroma. {ECO 0000269|PubMed 11912245, ECO 0000269|PubMed 17393420, ECO 0000269|PubMed 9260930, ECO 0000269|PubMed 9687576}. 
# UCSC	uc003qtf	human. [O15244-1]
# eggNOG	COG0477	LUCA
# eggNOG	KOG0255	Eukaryota
BLAST	swissprot:S22A2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S22A2_HUMAN
COXPRESdb	6582	http://coxpresdb.jp/data/gene/6582.shtml
CleanEx	HS_SLC22A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC22A2
DOI	10.1002/mrd.20697	http://dx.doi.org/10.1002/mrd.20697
DOI	10.1007/s004390000309	http://dx.doi.org/10.1007/s004390000309
DOI	10.1007/s10038-006-0087-0	http://dx.doi.org/10.1007/s10038-006-0087-0
DOI	10.1007/s11095-004-1193-3	http://dx.doi.org/10.1007/s11095-004-1193-3
DOI	10.1016/S0002-9440(10)61234-5	http://dx.doi.org/10.1016/S0002-9440(10)61234-5
DOI	10.1016/j.bcp.2007.03.004	http://dx.doi.org/10.1016/j.bcp.2007.03.004
DOI	10.1016/j.ejphar.2004.09.032	http://dx.doi.org/10.1016/j.ejphar.2004.09.032
DOI	10.1023/A:1013070128668	http://dx.doi.org/10.1023/A:1013070128668
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1089/dna.1997.16.871	http://dx.doi.org/10.1089/dna.1997.16.871
DOI	10.1097/00008571-200207000-00007	http://dx.doi.org/10.1097/00008571-200207000-00007
DOI	10.1097/01.ASN.0000019413.78751.46	http://dx.doi.org/10.1097/01.ASN.0000019413.78751.46
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1124/jpet.102.044404	http://dx.doi.org/10.1124/jpet.102.044404
DOI	10.1124/jpet.105.088104	http://dx.doi.org/10.1124/jpet.105.088104
DOI	10.1124/jpet.106.110346	http://dx.doi.org/10.1124/jpet.106.110346
DOI	10.1152/ajpcell.00622.2005	http://dx.doi.org/10.1152/ajpcell.00622.2005
DOI	10.1158/0008-5472.CAN-06-0769	http://dx.doi.org/10.1158/0008-5472.CAN-06-0769
DOI	10.2133/dmpk.20.379	http://dx.doi.org/10.2133/dmpk.20.379
DOI	10.2133/dmpk.21.432	http://dx.doi.org/10.2133/dmpk.21.432
DrugBank	DB00122	http://www.drugbank.ca/drugs/DB00122
DrugBank	DB00152	http://www.drugbank.ca/drugs/DB00152
DrugBank	DB00184	http://www.drugbank.ca/drugs/DB00184
DrugBank	DB00206	http://www.drugbank.ca/drugs/DB00206
DrugBank	DB00242	http://www.drugbank.ca/drugs/DB00242
DrugBank	DB00264	http://www.drugbank.ca/drugs/DB00264
DrugBank	DB00280	http://www.drugbank.ca/drugs/DB00280
DrugBank	DB00331	http://www.drugbank.ca/drugs/DB00331
DrugBank	DB00345	http://www.drugbank.ca/drugs/DB00345
DrugBank	DB00368	http://www.drugbank.ca/drugs/DB00368
DrugBank	DB00396	http://www.drugbank.ca/drugs/DB00396
DrugBank	DB00413	http://www.drugbank.ca/drugs/DB00413
DrugBank	DB00457	http://www.drugbank.ca/drugs/DB00457
DrugBank	DB00458	http://www.drugbank.ca/drugs/DB00458
DrugBank	DB00468	http://www.drugbank.ca/drugs/DB00468
DrugBank	DB00495	http://www.drugbank.ca/drugs/DB00495
DrugBank	DB00501	http://www.drugbank.ca/drugs/DB00501
DrugBank	DB00515	http://www.drugbank.ca/drugs/DB00515
DrugBank	DB00526	http://www.drugbank.ca/drugs/DB00526
DrugBank	DB00536	http://www.drugbank.ca/drugs/DB00536
DrugBank	DB00570	http://www.drugbank.ca/drugs/DB00570
DrugBank	DB00571	http://www.drugbank.ca/drugs/DB00571
DrugBank	DB00594	http://www.drugbank.ca/drugs/DB00594
DrugBank	DB00619	http://www.drugbank.ca/drugs/DB00619
DrugBank	DB00667	http://www.drugbank.ca/drugs/DB00667
DrugBank	DB00668	http://www.drugbank.ca/drugs/DB00668
DrugBank	DB00690	http://www.drugbank.ca/drugs/DB00690
DrugBank	DB00694	http://www.drugbank.ca/drugs/DB00694
DrugBank	DB00709	http://www.drugbank.ca/drugs/DB00709
DrugBank	DB00783	http://www.drugbank.ca/drugs/DB00783
DrugBank	DB00907	http://www.drugbank.ca/drugs/DB00907
DrugBank	DB00908	http://www.drugbank.ca/drugs/DB00908
DrugBank	DB00914	http://www.drugbank.ca/drugs/DB00914
DrugBank	DB00915	http://www.drugbank.ca/drugs/DB00915
DrugBank	DB00917	http://www.drugbank.ca/drugs/DB00917
DrugBank	DB00925	http://www.drugbank.ca/drugs/DB00925
DrugBank	DB00927	http://www.drugbank.ca/drugs/DB00927
DrugBank	DB00987	http://www.drugbank.ca/drugs/DB00987
DrugBank	DB00988	http://www.drugbank.ca/drugs/DB00988
DrugBank	DB01032	http://www.drugbank.ca/drugs/DB01032
DrugBank	DB01035	http://www.drugbank.ca/drugs/DB01035
DrugBank	DB01043	http://www.drugbank.ca/drugs/DB01043
DrugBank	DB01075	http://www.drugbank.ca/drugs/DB01075
DrugBank	DB01103	http://www.drugbank.ca/drugs/DB01103
DrugBank	DB01114	http://www.drugbank.ca/drugs/DB01114
DrugBank	DB01137	http://www.drugbank.ca/drugs/DB01137
DrugBank	DB01151	http://www.drugbank.ca/drugs/DB01151
DrugBank	DB01160	http://www.drugbank.ca/drugs/DB01160
DrugBank	DB01199	http://www.drugbank.ca/drugs/DB01199
DrugBank	DB01337	http://www.drugbank.ca/drugs/DB01337
DrugBank	DB01580	http://www.drugbank.ca/drugs/DB01580
EMBL	AB075951	http://www.ebi.ac.uk/ena/data/view/AB075951
EMBL	AJ251885	http://www.ebi.ac.uk/ena/data/view/AJ251885
EMBL	AK290787	http://www.ebi.ac.uk/ena/data/view/AK290787
EMBL	AL162582	http://www.ebi.ac.uk/ena/data/view/AL162582
EMBL	BC030978	http://www.ebi.ac.uk/ena/data/view/BC030978
EMBL	BC039899	http://www.ebi.ac.uk/ena/data/view/BC039899
EMBL	CH471051	http://www.ebi.ac.uk/ena/data/view/CH471051
EMBL	X98333	http://www.ebi.ac.uk/ena/data/view/X98333
Ensembl	ENST00000366953	http://www.ensembl.org/id/ENST00000366953
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_component	GO:0098793	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098793
GO_function	GO:0005326	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005326
GO_function	GO:0005329	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005329
GO_function	GO:0015101	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015101
GO_function	GO:0015220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015220
GO_function	GO:0015651	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015651
GO_process	GO:0006855	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006855
GO_process	GO:0007269	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007269
GO_process	GO:0007589	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007589
GO_process	GO:0015695	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015695
GO_process	GO:0015871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015871
GO_process	GO:0015872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015872
GO_process	GO:0042136	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042136
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC22A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC22A2
GeneID	6582	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6582
GeneTree	ENSGT00760000118852	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118852
H-InvDB	HIX0025014	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0025014
HGNC	HGNC:10966	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10966
HOGENOM	HOG000234568	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234568&db=HOGENOM6
HOVERGEN	HBG061545	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG061545&db=HOVERGEN
HPA	CAB068236	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB068236
HPA	CAB068237	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB068237
HPA	HPA008567	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA008567
InParanoid	O15244	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O15244
IntAct	O15244	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O15244*
InterPro	IPR004749	http://www.ebi.ac.uk/interpro/entry/IPR004749
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR005829	http://www.ebi.ac.uk/interpro/entry/IPR005829
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	6582	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6582
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6582	http://www.genome.jp/dbget-bin/www_bget?hsa:6582
KEGG_Orthology	KO:K08199	http://www.genome.jp/dbget-bin/www_bget?KO:K08199
MIM	602608	http://www.ncbi.nlm.nih.gov/omim/602608
OMA	PWAASNM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PWAASNM
OrthoDB	EOG091G05AC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05AC
PROSITE	PS00216	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00216
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:S22A2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S22A2_HUMAN
PSORT-B	swissprot:S22A2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S22A2_HUMAN
PSORT2	swissprot:S22A2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S22A2_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
PharmGKB	PA331	http://www.pharmgkb.org/do/serve?objId=PA331&objCls=Gene
Phobius	swissprot:S22A2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S22A2_HUMAN
PhylomeDB	O15244	http://phylomedb.org/?seqid=O15244
ProteinModelPortal	O15244	http://www.proteinmodelportal.org/query/uniprot/O15244
PubMed	10942111	http://www.ncbi.nlm.nih.gov/pubmed/10942111
PubMed	11758759	http://www.ncbi.nlm.nih.gov/pubmed/11758759
PubMed	11912245	http://www.ncbi.nlm.nih.gov/pubmed/11912245
PubMed	12089365	http://www.ncbi.nlm.nih.gov/pubmed/12089365
PubMed	12142729	http://www.ncbi.nlm.nih.gov/pubmed/12142729
PubMed	12538837	http://www.ncbi.nlm.nih.gov/pubmed/12538837
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15496291	http://www.ncbi.nlm.nih.gov/pubmed/15496291
PubMed	15783073	http://www.ncbi.nlm.nih.gov/pubmed/15783073
PubMed	16006492	http://www.ncbi.nlm.nih.gov/pubmed/16006492
PubMed	16272756	http://www.ncbi.nlm.nih.gov/pubmed/16272756
PubMed	16314463	http://www.ncbi.nlm.nih.gov/pubmed/16314463
PubMed	16394027	http://www.ncbi.nlm.nih.gov/pubmed/16394027
PubMed	16914559	http://www.ncbi.nlm.nih.gov/pubmed/16914559
PubMed	16951202	http://www.ncbi.nlm.nih.gov/pubmed/16951202
PubMed	17072098	http://www.ncbi.nlm.nih.gov/pubmed/17072098
PubMed	17111267	http://www.ncbi.nlm.nih.gov/pubmed/17111267
PubMed	17393420	http://www.ncbi.nlm.nih.gov/pubmed/17393420
PubMed	17582384	http://www.ncbi.nlm.nih.gov/pubmed/17582384
PubMed	9260930	http://www.ncbi.nlm.nih.gov/pubmed/9260930
PubMed	9687576	http://www.ncbi.nlm.nih.gov/pubmed/9687576
Reactome	R-HSA-112311	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112311
Reactome	R-HSA-181430	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-181430
Reactome	R-HSA-2161517	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2161517
Reactome	R-HSA-442660	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442660
Reactome	R-HSA-549127	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-549127
RefSeq	NP_003049	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003049
STRING	9606.ENSP00000355920	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000355920&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.19.30	http://www.tcdb.org/search/result.php?tc=2.A.1.19.30
TIGRFAMs	TIGR00898	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00898
UCSC	uc003qtf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003qtf&org=rat
UniGene	Hs.436385	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.436385
UniProtKB	S22A2_HUMAN	http://www.uniprot.org/uniprot/S22A2_HUMAN
UniProtKB-AC	O15244	http://www.uniprot.org/uniprot/O15244
charge	swissprot:S22A2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S22A2_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG0255	http://eggnogapi.embl.de/nog_data/html/tree/KOG0255
epestfind	swissprot:S22A2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S22A2_HUMAN
garnier	swissprot:S22A2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S22A2_HUMAN
helixturnhelix	swissprot:S22A2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S22A2_HUMAN
hmoment	swissprot:S22A2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S22A2_HUMAN
iep	swissprot:S22A2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S22A2_HUMAN
inforesidue	swissprot:S22A2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S22A2_HUMAN
neXtProt	NX_O15244	http://www.nextprot.org/db/entry/NX_O15244
octanol	swissprot:S22A2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S22A2_HUMAN
pepcoil	swissprot:S22A2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S22A2_HUMAN
pepdigest	swissprot:S22A2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S22A2_HUMAN
pepinfo	swissprot:S22A2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S22A2_HUMAN
pepnet	swissprot:S22A2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S22A2_HUMAN
pepstats	swissprot:S22A2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S22A2_HUMAN
pepwheel	swissprot:S22A2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S22A2_HUMAN
pepwindow	swissprot:S22A2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S22A2_HUMAN
sigcleave	swissprot:S22A2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S22A2_HUMAN
## Database	ID	URL or Descriptions
# AltName	ITPR3_HUMAN	IP3 receptor isoform 3
# AltName	ITPR3_HUMAN	Type 3 inositol 1,4,5-trisphosphate receptor
# BioGrid	109915	49
# ChiTaRS	ITPR3	human
# DOMAIN	ITPR3_HUMAN	The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand- binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. 
# DrugBank	DB00201	Caffeine
# Ensembl	ENST00000374316	ENSP00000363435; ENSG00000096433
# Ensembl	ENST00000605930	ENSP00000475177; ENSG00000096433
# FUNCTION	ITPR3_HUMAN	Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. 
# GO_component	GO:0005640	nuclear outer membrane; ISS:BHF-UCL.
# GO_component	GO:0005654	nucleoplasm; IEA:Ensembl.
# GO_component	GO:0005730	nucleolus; IEA:Ensembl.
# GO_component	GO:0005737	cytoplasm; ISS:BHF-UCL.
# GO_component	GO:0005783	endoplasmic reticulum; ISS:BHF-UCL.
# GO_component	GO:0005789	endoplasmic reticulum membrane; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0005903	brush border; ISS:BHF-UCL.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016529	sarcoplasmic reticulum; IBA:GO_Central.
# GO_component	GO:0030667	secretory granule membrane; IBA:GO_Central.
# GO_component	GO:0031095	platelet dense tubular network membrane; TAS:Reactome.
# GO_component	GO:0043025	neuronal cell body; ISS:BHF-UCL.
# GO_component	GO:0043209	myelin sheath; ISS:BHF-UCL.
# GO_component	GO:0043235	receptor complex; IDA:MGI.
# GO_component	GO:0045177	apical part of cell; ISS:BHF-UCL.
# GO_function	GO:0000822	inositol hexakisphosphate binding; ISS:BHF-UCL.
# GO_function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; ISS:UniProtKB.
# GO_function	GO:0005509	calcium ion binding; IBA:GO_Central.
# GO_function	GO:0015278	calcium-release channel activity; ISS:UniProtKB.
# GO_function	GO:0035091	phosphatidylinositol binding; IBA:GO_Central.
# GO_function	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding; ISS:BHF-UCL.
# GO_function	GO:0070679	inositol 1,4,5 trisphosphate binding; IDA:BHF-UCL.
# GO_process	GO:0007186	G-protein coupled receptor signaling pathway; ISS:BHF-UCL.
# GO_process	GO:0007204	positive regulation of cytosolic calcium ion concentration; ISS:BHF-UCL.
# GO_process	GO:0007613	memory; IEA:Ensembl.
# GO_process	GO:0030168	platelet activation; TAS:Reactome.
# GO_process	GO:0050796	regulation of insulin secretion; TAS:Reactome.
# GO_process	GO:0050913	sensory perception of bitter taste; IEA:Ensembl.
# GO_process	GO:0050916	sensory perception of sweet taste; IEA:Ensembl.
# GO_process	GO:0050917	sensory perception of umami taste; IEA:Ensembl.
# GO_process	GO:0051260	protein homooligomerization; ISS:BHF-UCL.
# GO_process	GO:0051291	protein heterooligomerization; ISS:BHF-UCL.
# GO_process	GO:0051592	response to calcium ion; IDA:BHF-UCL.
# GO_process	GO:0060291	long-term synaptic potentiation; IEA:Ensembl.
# GO_process	GO:0060402	calcium ion transport into cytosol; ISS:UniProtKB.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005730	nucleolus
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0008289	lipid binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0050877	neurological system process
# Gene3D	1.25.10.30	-; 2.
# Genevisible	Q14573	HS
# HGNC	HGNC:6182	ITPR3
# INTERACTION	ITPR3_HUMAN	Q13507 TRPC3; NbExp=5; IntAct=EBI-351055, EBI-520807; 
# IntAct	Q14573	29
# InterPro	IPR000493	InsP3_rcpt-bd
# InterPro	IPR000699	RIH_dom
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR013662	RIH_assoc-dom
# InterPro	IPR014821	Ins145_P3_rcpt
# InterPro	IPR015925	Ryanodine_recept-rel
# InterPro	IPR016093	MIR_motif
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00408	[Metabolic disease; Immune system disease; Endocrine disease] Type I diabetes mellitus
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04070	Phosphatidylinositol signaling system
# KEGG_Pathway	ko04114	Oocyte meiosis
# KEGG_Pathway	ko04270	Vascular smooth muscle contraction
# KEGG_Pathway	ko04540	Gap junction
# KEGG_Pathway	ko04713	Circadian entrainment
# KEGG_Pathway	ko04720	Long-term potentiation
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04724	Glutamatergic synapse
# KEGG_Pathway	ko04725	Cholinergic synapse
# KEGG_Pathway	ko04726	Serotonergic synapse
# KEGG_Pathway	ko04728	Dopaminergic synapse
# KEGG_Pathway	ko04730	Long-term depression
# KEGG_Pathway	ko04742	Taste transduction
# KEGG_Pathway	ko04912	GnRH signaling pathway
# KEGG_Pathway	ko04970	Salivary secretion
# KEGG_Pathway	ko04971	Gastric acid secretion
# KEGG_Pathway	ko04972	Pancreatic secretion
# KEGG_Pathway	ko05010	Alzheimer's disease
# MIM	147267	gene
# Organism	ITPR3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR13715	PTHR13715; 2
# PIR	A49873	A49873
# PRINTS	PR00779	INSP3RECEPTR
# PROSITE	PS50919	MIR; 5
# PTM	ITPR3_HUMAN	Phosphorylated on tyrosine residues. Phosphorylated by AKT1 on serine and/or threonine residues (By similarity). {ECO 0000250}. 
# Pfam	PF00520	Ion_trans
# Pfam	PF01365	RYDR_ITPR; 2
# Pfam	PF02815	MIR
# Pfam	PF08454	RIH_assoc
# Pfam	PF08709	Ins145_P3_rec
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-112043	PLC beta mediated events
# Reactome	R-HSA-114508	Effects of PIP2 hydrolysis
# Reactome	R-HSA-139853	Elevation of cytosolic Ca2+ levels
# Reactome	R-HSA-1489509	DAG and IP3 signaling
# Reactome	R-HSA-2029485	Role of phospholipids in phagocytosis
# Reactome	R-HSA-2871809	FCERI mediated Ca+2 mobilization
# Reactome	R-HSA-381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
# Reactome	R-HSA-4086398	Ca2+ pathway
# Reactome	R-HSA-422356	Regulation of insulin secretion
# Reactome	R-HSA-5218921	VEGFR2 mediated cell proliferation
# Reactome	R-HSA-5578775	Ion homeostasis
# Reactome	R-HSA-5607763	CLEC7A (Dectin-1) induces NFAT activation
# Reactome	R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
# RecName	ITPR3_HUMAN	Inositol 1,4,5-trisphosphate receptor type 3
# RefSeq	NP_002215	NM_002224.3
# SIMILARITY	Belongs to the InsP3 receptor family. {ECO	0000305}. 
# SIMILARITY	Contains 5 MIR domains. {ECO:0000255|PROSITE- ProRule	PRU00131}.
# SMART	SM00472	MIR; 4
# SUBCELLULAR LOCATION	ITPR3_HUMAN	Endoplasmic reticulum membrane; Multi-pass membrane protein. 
# SUBUNIT	ITPR3_HUMAN	Homotetramer. Interacts with TRPC1, TRPC3 and TRPC4. Interacts with TRPV4 (PubMed 18826956). Interacts with SIGMAR1 (By similarity). Interacts with PML and AKT1 (By similarity). Interacts with LRMP (via coiled-coil domain) (By similarity). Interacts with CABP1 (PubMed 12032348). Interacts with TMBIM4/LFG4 (PubMed 19553469). Interacts with CEMIP (PubMed 23936024). Interacts with TESPA1 (By similarity). Interacts with TMEM203 (PubMed 25996873). Interacts with BOK; regulates ITPR3 expression (By similarity). {ECO 0000250|UniProtKB P70227, ECO 0000250|UniProtKB Q63269, ECO 0000269|PubMed 12032348, ECO 0000269|PubMed 18826956, ECO 0000269|PubMed 19553469, ECO 0000269|PubMed 23936024, ECO 0000269|PubMed 25996873}. 
# SUPFAM	SSF100909	SSF100909; 2
# SUPFAM	SSF82109	SSF82109; 2
# TISSUE SPECIFICITY	ITPR3_HUMAN	Expressed in intestinal crypt and villus epithelial cells. 
# UCSC	uc063nyh	human
# eggNOG	ENOG410XR97	LUCA
# eggNOG	KOG3533	Eukaryota
BLAST	swissprot:ITPR3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ITPR3_HUMAN
BioCyc	ZFISH:ENSG00000096433-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000096433-MONOMER
COXPRESdb	3710	http://coxpresdb.jp/data/gene/3710.shtml
CleanEx	HS_ITPR3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ITPR3
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.102006299	http://dx.doi.org/10.1073/pnas.102006299
DOI	10.1074/jbc.C800184200	http://dx.doi.org/10.1074/jbc.C800184200
DOI	10.1091/mbc.E09-05-0385	http://dx.doi.org/10.1091/mbc.E09-05-0385
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1371/journal.pone.0069473	http://dx.doi.org/10.1371/journal.pone.0069473
DOI	10.1371/journal.pone.0127480	http://dx.doi.org/10.1371/journal.pone.0127480
DrugBank	DB00201	http://www.drugbank.ca/drugs/DB00201
EMBL	AL139044	http://www.ebi.ac.uk/ena/data/view/AL139044
EMBL	CH471081	http://www.ebi.ac.uk/ena/data/view/CH471081
EMBL	D26351	http://www.ebi.ac.uk/ena/data/view/D26351
EMBL	U01062	http://www.ebi.ac.uk/ena/data/view/U01062
Ensembl	ENST00000374316	http://www.ensembl.org/id/ENST00000374316
Ensembl	ENST00000605930	http://www.ensembl.org/id/ENST00000605930
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005640	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005640
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005730
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005903	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005903
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016529	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016529
GO_component	GO:0030667	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030667
GO_component	GO:0031095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031095
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0043209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043209
GO_component	GO:0043235	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043235
GO_component	GO:0045177	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045177
GO_function	GO:0000822	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000822
GO_function	GO:0005220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005220
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0015278	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015278
GO_function	GO:0035091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035091
GO_function	GO:0043533	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043533
GO_function	GO:0070679	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070679
GO_process	GO:0007186	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007186
GO_process	GO:0007204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007204
GO_process	GO:0007613	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007613
GO_process	GO:0030168	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030168
GO_process	GO:0050796	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050796
GO_process	GO:0050913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050913
GO_process	GO:0050916	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050916
GO_process	GO:0050917	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050917
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:0051291	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051291
GO_process	GO:0051592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051592
GO_process	GO:0060291	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060291
GO_process	GO:0060402	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060402
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005730
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
Gene3D	1.25.10.30	http://www.cathdb.info/version/latest/superfamily/1.25.10.30
GeneCards	ITPR3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ITPR3
GeneID	3710	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3710
GeneTree	ENSGT00760000119152	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119152
H-InvDB	HIX0005781	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0005781
HGNC	HGNC:6182	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6182
HOGENOM	HOG000007660	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007660&db=HOGENOM6
HOVERGEN	HBG052158	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052158&db=HOVERGEN
HPA	HPA003915	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA003915
HPA	HPA064704	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA064704
InParanoid	Q14573	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q14573
IntAct	Q14573	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q14573*
InterPro	IPR000493	http://www.ebi.ac.uk/interpro/entry/IPR000493
InterPro	IPR000699	http://www.ebi.ac.uk/interpro/entry/IPR000699
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR013662	http://www.ebi.ac.uk/interpro/entry/IPR013662
InterPro	IPR014821	http://www.ebi.ac.uk/interpro/entry/IPR014821
InterPro	IPR015925	http://www.ebi.ac.uk/interpro/entry/IPR015925
InterPro	IPR016093	http://www.ebi.ac.uk/interpro/entry/IPR016093
Jabion	3710	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3710
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00408	http://www.genome.jp/dbget-bin/www_bget?H00408
KEGG_Gene	hsa:3710	http://www.genome.jp/dbget-bin/www_bget?hsa:3710
KEGG_Orthology	KO:K04960	http://www.genome.jp/dbget-bin/www_bget?KO:K04960
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04070	http://www.genome.jp/kegg-bin/show_pathway?ko04070
KEGG_Pathway	ko04114	http://www.genome.jp/kegg-bin/show_pathway?ko04114
KEGG_Pathway	ko04270	http://www.genome.jp/kegg-bin/show_pathway?ko04270
KEGG_Pathway	ko04540	http://www.genome.jp/kegg-bin/show_pathway?ko04540
KEGG_Pathway	ko04713	http://www.genome.jp/kegg-bin/show_pathway?ko04713
KEGG_Pathway	ko04720	http://www.genome.jp/kegg-bin/show_pathway?ko04720
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
KEGG_Pathway	ko04725	http://www.genome.jp/kegg-bin/show_pathway?ko04725
KEGG_Pathway	ko04726	http://www.genome.jp/kegg-bin/show_pathway?ko04726
KEGG_Pathway	ko04728	http://www.genome.jp/kegg-bin/show_pathway?ko04728
KEGG_Pathway	ko04730	http://www.genome.jp/kegg-bin/show_pathway?ko04730
KEGG_Pathway	ko04742	http://www.genome.jp/kegg-bin/show_pathway?ko04742
KEGG_Pathway	ko04912	http://www.genome.jp/kegg-bin/show_pathway?ko04912
KEGG_Pathway	ko04970	http://www.genome.jp/kegg-bin/show_pathway?ko04970
KEGG_Pathway	ko04971	http://www.genome.jp/kegg-bin/show_pathway?ko04971
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
MIM	147267	http://www.ncbi.nlm.nih.gov/omim/147267
MINT	MINT-4991384	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4991384
OMA	FVHELFY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FVHELFY
OrthoDB	EOG091G00T2	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00T2
PANTHER	PTHR13715	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13715
PRINTS	PR00779	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00779
PROSITE	PS50919	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50919
PSORT	swissprot:ITPR3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ITPR3_HUMAN
PSORT-B	swissprot:ITPR3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ITPR3_HUMAN
PSORT2	swissprot:ITPR3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ITPR3_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF01365	http://pfam.xfam.org/family/PF01365
Pfam	PF02815	http://pfam.xfam.org/family/PF02815
Pfam	PF08454	http://pfam.xfam.org/family/PF08454
Pfam	PF08709	http://pfam.xfam.org/family/PF08709
PharmGKB	PA29980	http://www.pharmgkb.org/do/serve?objId=PA29980&objCls=Gene
Phobius	swissprot:ITPR3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ITPR3_HUMAN
PhylomeDB	Q14573	http://phylomedb.org/?seqid=Q14573
ProteinModelPortal	Q14573	http://www.proteinmodelportal.org/query/uniprot/Q14573
PubMed	12032348	http://www.ncbi.nlm.nih.gov/pubmed/12032348
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18826956	http://www.ncbi.nlm.nih.gov/pubmed/18826956
PubMed	19553469	http://www.ncbi.nlm.nih.gov/pubmed/19553469
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	23936024	http://www.ncbi.nlm.nih.gov/pubmed/23936024
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25996873	http://www.ncbi.nlm.nih.gov/pubmed/25996873
PubMed	8081734	http://www.ncbi.nlm.nih.gov/pubmed/8081734
PubMed	8288584	http://www.ncbi.nlm.nih.gov/pubmed/8288584
Reactome	R-HSA-112043	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112043
Reactome	R-HSA-114508	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-114508
Reactome	R-HSA-139853	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-139853
Reactome	R-HSA-1489509	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1489509
Reactome	R-HSA-2029485	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2029485
Reactome	R-HSA-2871809	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2871809
Reactome	R-HSA-381676	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-381676
Reactome	R-HSA-4086398	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-4086398
Reactome	R-HSA-422356	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-422356
Reactome	R-HSA-5218921	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5218921
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
Reactome	R-HSA-5607763	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5607763
Reactome	R-HSA-983695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983695
RefSeq	NP_002215	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002215
SMART	SM00472	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00472
STRING	9606.ENSP00000363435	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000363435&targetmode=cogs
SUPFAM	SSF100909	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF100909
SUPFAM	SSF82109	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82109
UCSC	uc063nyh	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc063nyh&org=rat
UniGene	Hs.65758	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.65758
UniProtKB	ITPR3_HUMAN	http://www.uniprot.org/uniprot/ITPR3_HUMAN
UniProtKB-AC	Q14573	http://www.uniprot.org/uniprot/Q14573
charge	swissprot:ITPR3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ITPR3_HUMAN
eggNOG	ENOG410XR97	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XR97
eggNOG	KOG3533	http://eggnogapi.embl.de/nog_data/html/tree/KOG3533
epestfind	swissprot:ITPR3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ITPR3_HUMAN
garnier	swissprot:ITPR3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ITPR3_HUMAN
helixturnhelix	swissprot:ITPR3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ITPR3_HUMAN
hmoment	swissprot:ITPR3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ITPR3_HUMAN
iep	swissprot:ITPR3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ITPR3_HUMAN
inforesidue	swissprot:ITPR3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ITPR3_HUMAN
neXtProt	NX_Q14573	http://www.nextprot.org/db/entry/NX_Q14573
octanol	swissprot:ITPR3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ITPR3_HUMAN
pepcoil	swissprot:ITPR3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ITPR3_HUMAN
pepdigest	swissprot:ITPR3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ITPR3_HUMAN
pepinfo	swissprot:ITPR3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ITPR3_HUMAN
pepnet	swissprot:ITPR3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ITPR3_HUMAN
pepstats	swissprot:ITPR3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ITPR3_HUMAN
pepwheel	swissprot:ITPR3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ITPR3_HUMAN
pepwindow	swissprot:ITPR3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ITPR3_HUMAN
sigcleave	swissprot:ITPR3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ITPR3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S26A1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H2B4-1; Sequence=Displayed; Name=2; IsoId=Q9H2B4-2; Sequence=VSP_043671, VSP_043672; Note=No experimental confirmation available.; 
# AltName	S26A1_HUMAN	Solute carrier family 26 member 1
# CCDS	CCDS33933	-. [Q9H2B4-2]
# CCDS	CCDS33934	-. [Q9H2B4-1]
# ChiTaRS	SLC26A1	human
# Ensembl	ENST00000361661	ENSP00000354721; ENSG00000145217. [Q9H2B4-1]
# Ensembl	ENST00000398516	ENSP00000381528; ENSG00000145217. [Q9H2B4-1]
# Ensembl	ENST00000398520	ENSP00000381532; ENSG00000145217. [Q9H2B4-2]
# Ensembl	ENST00000622731	ENSP00000483506; ENSG00000145217. [Q9H2B4-2]
# FUNCTION	S26A1_HUMAN	High affinity uptake of sulfate. Accepts oxalate, but not succinate as a cosubstrate. Mediates sulfate and oxalate transport. {ECO 0000269|PubMed 12713736}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; TAS:UniProtKB.
# GO_function	GO:0005254	chloride channel activity; IBA:GO_Central.
# GO_function	GO:0008271	secondary active sulfate transmembrane transporter activity; IEA:InterPro.
# GO_function	GO:0015106	bicarbonate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015108	chloride transmembrane transporter activity; ISS:UniProtKB.
# GO_function	GO:0015116	sulfate transmembrane transporter activity; ISS:UniProtKB.
# GO_function	GO:0019531	oxalate transmembrane transporter activity; ISS:UniProtKB.
# GO_function	S26A1_HUMAN	GO 0015301 anion anion antiporter activity; ISS UniProtKB.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006821	chloride transport; ISS:UniProtKB.
# GO_process	GO:0008272	sulfate transport; ISS:UniProtKB.
# GO_process	GO:0015701	bicarbonate transport; IBA:GO_Central.
# GO_process	GO:0019532	oxalate transport; ISS:UniProtKB.
# GO_process	GO:0042391	regulation of membrane potential; IBA:GO_Central.
# GO_process	GO:0050428	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process; TAS:Reactome.
# GO_process	GO:0051453	regulation of intracellular pH; IBA:GO_Central.
# GO_process	GO:1902476	chloride transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006790	sulfur compound metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.30.750.24	-; 2.
# Genevisible	Q9H2B4	HS
# HGNC	HGNC:10993	SLC26A1
# InterPro	IPR001902	SLC26A/SulP_fam
# InterPro	IPR002645	STAS_dom
# InterPro	IPR011547	SLC26A/SulP_dom
# InterPro	IPR018045	S04_transporter_CS
# InterPro	IPR030331	SLC26A1
# KEGG_Brite	ko02001	Solute carrier family
# MIM	610130	gene
# Organism	S26A1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11814	PTHR11814; 2
# PANTHER	PTHR11814:SF31	PTHR11814:SF31; 2
# PROSITE	PS01130	SLC26A
# PROSITE	PS50801	STAS
# Pfam	PF00916	Sulfate_transp
# Pfam	PF01740	STAS
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-174362	Transport and synthesis of PAPS
# Reactome	R-HSA-427601	Multifunctional anion exchangers
# RecName	S26A1_HUMAN	Sulfate anion transporter 1
# RefSeq	NP_071325	NM_022042.3. [Q9H2B4-1]
# RefSeq	NP_602297	NM_134425.2. [Q9H2B4-2]
# RefSeq	NP_998778	NM_213613.3. [Q9H2B4-1]
# SIMILARITY	Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. {ECO	0000305}. 
# SIMILARITY	Contains 1 STAS domain. {ECO:0000255|PROSITE- ProRule	PRU00198}.
# SUBCELLULAR LOCATION	S26A1_HUMAN	Membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUPFAM	SSF52091	SSF52091; 2
# TCDB	2.A.53.2.16	the sulfate permease (sulp) family
# TIGRFAMs	TIGR00815	sulP
# TISSUE SPECIFICITY	Expressed most abundantly in the kidney and liver, with lower levels in the pancreas, testis, brain, small intestine, colon, and lung. {ECO:0000269|PubMed	12713736}. 
# UCSC	uc003gbx	human. [Q9H2B4-1]
# eggNOG	COG0659	LUCA
# eggNOG	KOG0236	Eukaryota
BLAST	swissprot:S26A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S26A1_HUMAN
BioCyc	ZFISH:ENSG00000145217-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000145217-MONOMER
COXPRESdb	10861	http://coxpresdb.jp/data/gene/10861.shtml
CleanEx	HS_SAT1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SAT1
CleanEx	HS_SLC26A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC26A1
DOI	10.1006/geno.2000.6355	http://dx.doi.org/10.1006/geno.2000.6355
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1089/104454903321515913	http://dx.doi.org/10.1089/104454903321515913
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC019103	http://www.ebi.ac.uk/ena/data/view/AC019103
EMBL	AF297659	http://www.ebi.ac.uk/ena/data/view/AF297659
EMBL	AK292747	http://www.ebi.ac.uk/ena/data/view/AK292747
EMBL	AY124771	http://www.ebi.ac.uk/ena/data/view/AY124771
EMBL	BC015517	http://www.ebi.ac.uk/ena/data/view/BC015517
EMBL	CH471131	http://www.ebi.ac.uk/ena/data/view/CH471131
EMBL	CH471131	http://www.ebi.ac.uk/ena/data/view/CH471131
Ensembl	ENST00000361661	http://www.ensembl.org/id/ENST00000361661
Ensembl	ENST00000398516	http://www.ensembl.org/id/ENST00000398516
Ensembl	ENST00000398520	http://www.ensembl.org/id/ENST00000398520
Ensembl	ENST00000622731	http://www.ensembl.org/id/ENST00000622731
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0008271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008271
GO_function	GO:0015106	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015106
GO_function	GO:0015108	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015108
GO_function	GO:0015116	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015116
GO_function	GO:0015301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015301
GO_function	GO:0019531	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019531
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006821
GO_process	GO:0008272	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008272
GO_process	GO:0015701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015701
GO_process	GO:0019532	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019532
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0050428	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050428
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.30.750.24	http://www.cathdb.info/version/latest/superfamily/3.30.750.24
GeneCards	SLC26A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC26A1
GeneID	10861	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10861
GeneTree	ENSGT00760000119026	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119026
HGNC	HGNC:10993	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10993
HOGENOM	HOG000006546	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006546&db=HOGENOM6
HOVERGEN	HBG000639	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000639&db=HOVERGEN
HPA	HPA041654	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA041654
InParanoid	Q9H2B4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9H2B4
InterPro	IPR001902	http://www.ebi.ac.uk/interpro/entry/IPR001902
InterPro	IPR002645	http://www.ebi.ac.uk/interpro/entry/IPR002645
InterPro	IPR011547	http://www.ebi.ac.uk/interpro/entry/IPR011547
InterPro	IPR018045	http://www.ebi.ac.uk/interpro/entry/IPR018045
InterPro	IPR030331	http://www.ebi.ac.uk/interpro/entry/IPR030331
Jabion	10861	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10861
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:10861	http://www.genome.jp/dbget-bin/www_bget?hsa:10861
KEGG_Orthology	KO:K14700	http://www.genome.jp/dbget-bin/www_bget?KO:K14700
MIM	610130	http://www.ncbi.nlm.nih.gov/omim/610130
OMA	LPAFLHC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LPAFLHC
OrthoDB	EOG091G07RT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07RT
PANTHER	PTHR11814	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11814
PANTHER	PTHR11814:SF31	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11814:SF31
PROSITE	PS01130	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01130
PROSITE	PS50801	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50801
PSORT	swissprot:S26A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S26A1_HUMAN
PSORT-B	swissprot:S26A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S26A1_HUMAN
PSORT2	swissprot:S26A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S26A1_HUMAN
Pfam	PF00916	http://pfam.xfam.org/family/PF00916
Pfam	PF01740	http://pfam.xfam.org/family/PF01740
PharmGKB	PA400	http://www.pharmgkb.org/do/serve?objId=PA400&objCls=Gene
Phobius	swissprot:S26A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S26A1_HUMAN
PhylomeDB	Q9H2B4	http://phylomedb.org/?seqid=Q9H2B4
ProteinModelPortal	Q9H2B4	http://www.proteinmodelportal.org/query/uniprot/Q9H2B4
PubMed	11087667	http://www.ncbi.nlm.nih.gov/pubmed/11087667
PubMed	12713736	http://www.ncbi.nlm.nih.gov/pubmed/12713736
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
Reactome	R-HSA-174362	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-174362
Reactome	R-HSA-427601	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-427601
RefSeq	NP_071325	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_071325
RefSeq	NP_602297	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_602297
RefSeq	NP_998778	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_998778
STRING	9606.ENSP00000354721	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000354721&targetmode=cogs
SUPFAM	SSF52091	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52091
TCDB	2.A.53.2.16	http://www.tcdb.org/search/result.php?tc=2.A.53.2.16
TIGRFAMs	TIGR00815	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00815
UCSC	uc003gbx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003gbx&org=rat
UniGene	Hs.658244	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.658244
UniProtKB	S26A1_HUMAN	http://www.uniprot.org/uniprot/S26A1_HUMAN
UniProtKB-AC	Q9H2B4	http://www.uniprot.org/uniprot/Q9H2B4
charge	swissprot:S26A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S26A1_HUMAN
eggNOG	COG0659	http://eggnogapi.embl.de/nog_data/html/tree/COG0659
eggNOG	KOG0236	http://eggnogapi.embl.de/nog_data/html/tree/KOG0236
epestfind	swissprot:S26A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S26A1_HUMAN
garnier	swissprot:S26A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S26A1_HUMAN
helixturnhelix	swissprot:S26A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S26A1_HUMAN
hmoment	swissprot:S26A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S26A1_HUMAN
iep	swissprot:S26A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S26A1_HUMAN
inforesidue	swissprot:S26A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S26A1_HUMAN
neXtProt	NX_Q9H2B4	http://www.nextprot.org/db/entry/NX_Q9H2B4
octanol	swissprot:S26A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S26A1_HUMAN
pepcoil	swissprot:S26A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S26A1_HUMAN
pepdigest	swissprot:S26A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S26A1_HUMAN
pepinfo	swissprot:S26A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S26A1_HUMAN
pepnet	swissprot:S26A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S26A1_HUMAN
pepstats	swissprot:S26A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S26A1_HUMAN
pepwheel	swissprot:S26A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S26A1_HUMAN
pepwindow	swissprot:S26A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S26A1_HUMAN
sigcleave	swissprot:S26A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S26A1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CA2D3_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8IZS8-1; Sequence=Displayed; Name=2; IsoId=Q8IZS8-2; Sequence=VSP_028064; Name=3; IsoId=Q8IZS8-3; Sequence=VSP_028064, VSP_028065, VSP_028066, VSP_028067; 
# AltName	CA2D3_HUMAN	Voltage-gated calcium channel subunit alpha-2/delta-3
# AltName	CA2D3_HUMAN	Voltage-gated calcium channel subunit alpha-2/delta-3
# CCDS	CCDS54598	-. [Q8IZS8-1]
# ChiTaRS	CACNA2D3	human
# DOMAIN	CA2D3_HUMAN	The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha- 1 (CACNA1) subunit to the plasma membrane by an integrin-like switch. {ECO 0000250}. 
# DrugBank	DB00381	Amlodipine
# DrugBank	DB00421	Spironolactone
# DrugBank	DB06712	Nilvadipine
# Ensembl	ENST00000288197	ENSP00000288197; ENSG00000157445. [Q8IZS8-1]
# Ensembl	ENST00000415676	ENSP00000389506; ENSG00000157445. [Q8IZS8-1]
# Ensembl	ENST00000471363	ENSP00000418228; ENSG00000157445. [Q8IZS8-3]
# Ensembl	ENST00000474759	ENSP00000419101; ENSG00000157445. [Q8IZS8-1]
# Ensembl	ENST00000490478	ENSP00000417279; ENSG00000157445. [Q8IZS8-2]
# Ensembl	ENST00000620722	ENSP00000478969; ENSG00000157445. [Q8IZS8-3]
# ExpressionAtlas	Q8IZS8	baseline and differential
# FUNCTION	CA2D3_HUMAN	The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity). {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005891	voltage-gated calcium channel complex; IBA:GO_Central.
# GO_function	GO:0005244	voltage-gated ion channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0005246	calcium channel regulator activity; IBA:GO_Central.
# GO_function	GO:0005262	calcium channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0051924	regulation of calcium ion transport; IBA:GO_Central.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:0070588	calcium ion transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.410	-; 1.
# Genevisible	Q8IZS8	HS
# HGNC	HGNC:15460	CACNA2D3
# InterPro	IPR002035	VWF_A
# InterPro	IPR013608	VWA_N
# InterPro	IPR013680	VDCC_a2/dsu
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04010	MAPK signaling pathway
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05410	Hypertrophic cardiomyopathy (HCM)
# KEGG_Pathway	ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
# KEGG_Pathway	ko05414	Dilated cardiomyopathy
# MIM	606399	gene
# MISCELLANEOUS	CA2D3_HUMAN	In contrast to CACNA2D1 and CACNA2D2, it does not bind gabapentin, an antiepileptic drug. 
# Organism	CA2D3_HUMAN	Homo sapiens (Human)
# PROSITE	PS50234	VWFA
# PTM	CA2D3_HUMAN	May be proteolytically processed into subunits alpha-2-3 and delta-3 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role (By similarity). {ECO 0000250}. 
# PTM	CA2D3_HUMAN	N-glycosylated. {ECO 0000250}. 
# Pfam	PF08399	VWA_N
# Pfam	PF08473	VGCC_alpha2
# Pfam	PF13768	VWA_3
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-112308	Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# Reactome	R-HSA-5576893	Phase 2 - plateau phase
# Reactome	R-HSA-5576894	Phase 1 - inactivation of fast Na+ channels
# RecName	CA2D3_HUMAN	Voltage-dependent calcium channel subunit alpha-2-3
# RecName	CA2D3_HUMAN	Voltage-dependent calcium channel subunit alpha-2-3
# RecName	CA2D3_HUMAN	Voltage-dependent calcium channel subunit alpha-2/delta-3
# RecName	CA2D3_HUMAN	Voltage-dependent calcium channel subunit delta-3
# RefSeq	NP_060868	NM_018398.2. [Q8IZS8-1]
# SIMILARITY	Belongs to the calcium channel subunit alpha-2/delta family. {ECO	0000305}. 
# SIMILARITY	Contains 1 VWFA domain. {ECO:0000255|PROSITE- ProRule	PRU00219}.
# SIMILARITY	Contains 1 cache domain. {ECO	0000305}. 
# SMART	SM00327	VWA
# SUBCELLULAR LOCATION	CA2D3_HUMAN	Membrane {ECO 0000305}; Single-pass type I membrane protein {ECO 0000305}. 
# SUBUNIT	CA2D3_HUMAN	Dimer formed of alpha-2-2 and delta-2 chains; disulfide- linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1 1 1 1 ratio (By similarity). {ECO 0000250}. 
# SUPFAM	SSF53300	SSF53300
# TCDB	8.A.18.3	the ca(2+) channel auxiliary subunit Alpha2Delta types 1-4 (cca-Alpha2Delta) family
# TISSUE SPECIFICITY	CA2D3_HUMAN	Only detected in brain. Not present in lung, testis, aorta, spleen, jejunum, ventricular muscle and kidney (at protein level). According to PubMed 11687876, it is brain- specific, while according to PubMed 11245980, it is widely expressed. {ECO 0000269|PubMed 11687876}. 
# UCSC	uc003dhf	human. [Q8IZS8-1]
# eggNOG	ENOG410XPDX	LUCA
# eggNOG	KOG2353	Eukaryota
BLAST	swissprot:CA2D3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CA2D3_HUMAN
COXPRESdb	55799	http://coxpresdb.jp/data/gene/55799.shtml
CleanEx	HS_CACNA2D3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CACNA2D3
DOI	10.1007/s00232-001-0072-7	http://dx.doi.org/10.1007/s00232-001-0072-7
DOI	10.1016/S0378-1119(00)00600-4	http://dx.doi.org/10.1016/S0378-1119(00)00600-4
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1124/mol.62.3.485	http://dx.doi.org/10.1124/mol.62.3.485
DrugBank	DB00381	http://www.drugbank.ca/drugs/DB00381
DrugBank	DB00421	http://www.drugbank.ca/drugs/DB00421
DrugBank	DB06712	http://www.drugbank.ca/drugs/DB06712
EMBL	AF516696	http://www.ebi.ac.uk/ena/data/view/AF516696
EMBL	AJ272213	http://www.ebi.ac.uk/ena/data/view/AJ272213
EMBL	AJ272268	http://www.ebi.ac.uk/ena/data/view/AJ272268
EMBL	BC137502	http://www.ebi.ac.uk/ena/data/view/BC137502
EMBL	BC137505	http://www.ebi.ac.uk/ena/data/view/BC137505
Ensembl	ENST00000288197	http://www.ensembl.org/id/ENST00000288197
Ensembl	ENST00000415676	http://www.ensembl.org/id/ENST00000415676
Ensembl	ENST00000471363	http://www.ensembl.org/id/ENST00000471363
Ensembl	ENST00000474759	http://www.ensembl.org/id/ENST00000474759
Ensembl	ENST00000490478	http://www.ensembl.org/id/ENST00000490478
Ensembl	ENST00000620722	http://www.ensembl.org/id/ENST00000620722
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005891
GO_function	GO:0005244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005244
GO_function	GO:0005246	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005246
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0051924	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051924
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.410	http://www.cathdb.info/version/latest/superfamily/3.40.50.410
GeneCards	CACNA2D3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CACNA2D3
GeneID	55799	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55799
GeneTree	ENSGT00530000062904	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062904
HGNC	HGNC:15460	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:15460
HOGENOM	HOG000010247	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000010247&db=HOGENOM6
HOVERGEN	HBG107124	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG107124&db=HOVERGEN
HPA	HPA030849	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA030849
HPA	HPA030850	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA030850
InParanoid	Q8IZS8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8IZS8
InterPro	IPR002035	http://www.ebi.ac.uk/interpro/entry/IPR002035
InterPro	IPR013608	http://www.ebi.ac.uk/interpro/entry/IPR013608
InterPro	IPR013680	http://www.ebi.ac.uk/interpro/entry/IPR013680
Jabion	55799	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55799
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:55799	http://www.genome.jp/dbget-bin/www_bget?hsa:55799
KEGG_Orthology	KO:K04860	http://www.genome.jp/dbget-bin/www_bget?KO:K04860
KEGG_Pathway	ko04010	http://www.genome.jp/kegg-bin/show_pathway?ko04010
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05410	http://www.genome.jp/kegg-bin/show_pathway?ko05410
KEGG_Pathway	ko05412	http://www.genome.jp/kegg-bin/show_pathway?ko05412
KEGG_Pathway	ko05414	http://www.genome.jp/kegg-bin/show_pathway?ko05414
MIM	606399	http://www.ncbi.nlm.nih.gov/omim/606399
OMA	AALDGKC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AALDGKC
OrthoDB	EOG091G00UY	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00UY
PROSITE	PS50234	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50234
PSORT	swissprot:CA2D3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CA2D3_HUMAN
PSORT-B	swissprot:CA2D3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CA2D3_HUMAN
PSORT2	swissprot:CA2D3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CA2D3_HUMAN
Pfam	PF08399	http://pfam.xfam.org/family/PF08399
Pfam	PF08473	http://pfam.xfam.org/family/PF08473
Pfam	PF13768	http://pfam.xfam.org/family/PF13768
PharmGKB	PA26013	http://www.pharmgkb.org/do/serve?objId=PA26013&objCls=Gene
Phobius	swissprot:CA2D3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CA2D3_HUMAN
PhylomeDB	Q8IZS8	http://phylomedb.org/?seqid=Q8IZS8
ProteinModelPortal	Q8IZS8	http://www.proteinmodelportal.org/query/uniprot/Q8IZS8
PubMed	11245980	http://www.ncbi.nlm.nih.gov/pubmed/11245980
PubMed	11687876	http://www.ncbi.nlm.nih.gov/pubmed/11687876
PubMed	12181424	http://www.ncbi.nlm.nih.gov/pubmed/12181424
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-112308	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112308
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
Reactome	R-HSA-5576893	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576893
Reactome	R-HSA-5576894	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576894
RefSeq	NP_060868	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060868
SMART	SM00327	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00327
STRING	9606.ENSP00000419101	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000419101&targetmode=cogs
SUPFAM	SSF53300	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53300
TCDB	8.A.18.3	http://www.tcdb.org/search/result.php?tc=8.A.18.3
UCSC	uc003dhf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003dhf&org=rat
UniGene	Hs.656687	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.656687
UniProtKB	CA2D3_HUMAN	http://www.uniprot.org/uniprot/CA2D3_HUMAN
UniProtKB-AC	Q8IZS8	http://www.uniprot.org/uniprot/Q8IZS8
charge	swissprot:CA2D3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CA2D3_HUMAN
eggNOG	ENOG410XPDX	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPDX
eggNOG	KOG2353	http://eggnogapi.embl.de/nog_data/html/tree/KOG2353
epestfind	swissprot:CA2D3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CA2D3_HUMAN
garnier	swissprot:CA2D3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CA2D3_HUMAN
helixturnhelix	swissprot:CA2D3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CA2D3_HUMAN
hmoment	swissprot:CA2D3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CA2D3_HUMAN
iep	swissprot:CA2D3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CA2D3_HUMAN
inforesidue	swissprot:CA2D3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CA2D3_HUMAN
neXtProt	NX_Q8IZS8	http://www.nextprot.org/db/entry/NX_Q8IZS8
octanol	swissprot:CA2D3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CA2D3_HUMAN
pepcoil	swissprot:CA2D3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CA2D3_HUMAN
pepdigest	swissprot:CA2D3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CA2D3_HUMAN
pepinfo	swissprot:CA2D3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CA2D3_HUMAN
pepnet	swissprot:CA2D3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CA2D3_HUMAN
pepstats	swissprot:CA2D3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CA2D3_HUMAN
pepwheel	swissprot:CA2D3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CA2D3_HUMAN
pepwindow	swissprot:CA2D3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CA2D3_HUMAN
sigcleave	swissprot:CA2D3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CA2D3_HUMAN
## Database	ID	URL or Descriptions
# AltName	COPT2_HUMAN	Copper transporter 2
# AltName	COPT2_HUMAN	Solute carrier family 31 member 2
# BioGrid	107713	6
# DrugBank	DB00515	Cisplatin
# DrugBank	DB00958	Carboplatin
# Ensembl	ENST00000259392	ENSP00000259392; ENSG00000136867
# ExpressionAtlas	O15432	baseline and differential
# FUNCTION	COPT2_HUMAN	Involved in low-affinity copper uptake. {ECO 0000305}. 
# GO_component	GO:0005770	late endosome; IEA:Ensembl.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0055037	recycling endosome; IEA:Ensembl.
# GO_function	GO:0005375	copper ion transmembrane transporter activity; TAS:ProtInc.
# GO_process	GO:0006825	copper ion transport; TAS:ProtInc.
# GO_process	GO:0006878	cellular copper ion homeostasis; IEA:Ensembl.
# GO_process	GO:1902311	regulation of copper ion transmembrane transport; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005768	endosome
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# Genevisible	O15432	HS
# HGNC	HGNC:11017	SLC31A2
# InterPro	IPR007274	Cop_transporter
# KEGG_Brite	ko02001	Solute carrier family
# MIM	603088	gene
# Organism	COPT2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12483	PTHR12483
# Pfam	PF04145	Ctr
# Proteomes	UP000005640	Chromosome 9
# RecName	COPT2_HUMAN	Probable low affinity copper uptake protein 2
# RefSeq	NP_001851	NM_001860.2
# SIMILARITY	Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	COPT2_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	1.A.56.1	the copper transporter (ctr) family
# TISSUE SPECIFICITY	COPT2_HUMAN	Ubiquitous. 
# eggNOG	ENOG4111I8D	LUCA
# eggNOG	KOG3386	Eukaryota
BLAST	swissprot:COPT2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:COPT2_HUMAN
BioCyc	ZFISH:ENSG00000136867-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000136867-MONOMER
COXPRESdb	1318	http://coxpresdb.jp/data/gene/1318.shtml
CleanEx	HS_SLC31A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC31A2
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1073/pnas.94.14.7481	http://dx.doi.org/10.1073/pnas.94.14.7481
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00515	http://www.drugbank.ca/drugs/DB00515
DrugBank	DB00958	http://www.drugbank.ca/drugs/DB00958
EMBL	BC026252	http://www.ebi.ac.uk/ena/data/view/BC026252
EMBL	U83461	http://www.ebi.ac.uk/ena/data/view/U83461
Ensembl	ENST00000259392	http://www.ensembl.org/id/ENST00000259392
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005770	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005770
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0055037	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055037
GO_function	GO:0005375	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005375
GO_process	GO:0006825	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006825
GO_process	GO:0006878	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006878
GO_process	GO:1902311	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902311
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GeneCards	SLC31A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC31A2
GeneID	1318	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1318
GeneTree	ENSGT00530000063415	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063415
HGNC	HGNC:11017	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11017
HOGENOM	HOG000195393	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000195393&db=HOGENOM6
HOVERGEN	HBG106679	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG106679&db=HOVERGEN
HPA	HPA014861	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014861
InParanoid	O15432	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O15432
InterPro	IPR007274	http://www.ebi.ac.uk/interpro/entry/IPR007274
Jabion	1318	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1318
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:1318	http://www.genome.jp/dbget-bin/www_bget?hsa:1318
KEGG_Orthology	KO:K14687	http://www.genome.jp/dbget-bin/www_bget?KO:K14687
MIM	603088	http://www.ncbi.nlm.nih.gov/omim/603088
MINT	MINT-2998980	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-2998980
OMA	YPLLRMV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YPLLRMV
OrthoDB	EOG091G0VVR	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0VVR
PANTHER	PTHR12483	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12483
PSORT	swissprot:COPT2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:COPT2_HUMAN
PSORT-B	swissprot:COPT2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:COPT2_HUMAN
PSORT2	swissprot:COPT2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:COPT2_HUMAN
Pfam	PF04145	http://pfam.xfam.org/family/PF04145
PharmGKB	PA35886	http://www.pharmgkb.org/do/serve?objId=PA35886&objCls=Gene
Phobius	swissprot:COPT2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:COPT2_HUMAN
PhylomeDB	O15432	http://phylomedb.org/?seqid=O15432
ProteinModelPortal	O15432	http://www.proteinmodelportal.org/query/uniprot/O15432
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	9207117	http://www.ncbi.nlm.nih.gov/pubmed/9207117
RefSeq	NP_001851	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001851
STRING	9606.ENSP00000259392	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000259392&targetmode=cogs
TCDB	1.A.56.1	http://www.tcdb.org/search/result.php?tc=1.A.56.1
UniGene	Hs.24030	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.24030
UniProtKB	COPT2_HUMAN	http://www.uniprot.org/uniprot/COPT2_HUMAN
UniProtKB-AC	O15432	http://www.uniprot.org/uniprot/O15432
charge	swissprot:COPT2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:COPT2_HUMAN
eggNOG	ENOG4111I8D	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111I8D
eggNOG	KOG3386	http://eggnogapi.embl.de/nog_data/html/tree/KOG3386
epestfind	swissprot:COPT2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:COPT2_HUMAN
garnier	swissprot:COPT2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:COPT2_HUMAN
helixturnhelix	swissprot:COPT2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:COPT2_HUMAN
hmoment	swissprot:COPT2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:COPT2_HUMAN
iep	swissprot:COPT2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:COPT2_HUMAN
inforesidue	swissprot:COPT2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:COPT2_HUMAN
neXtProt	NX_O15432	http://www.nextprot.org/db/entry/NX_O15432
octanol	swissprot:COPT2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:COPT2_HUMAN
pepcoil	swissprot:COPT2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:COPT2_HUMAN
pepdigest	swissprot:COPT2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:COPT2_HUMAN
pepinfo	swissprot:COPT2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:COPT2_HUMAN
pepnet	swissprot:COPT2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:COPT2_HUMAN
pepstats	swissprot:COPT2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:COPT2_HUMAN
pepwheel	swissprot:COPT2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:COPT2_HUMAN
pepwindow	swissprot:COPT2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:COPT2_HUMAN
sigcleave	swissprot:COPT2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:COPT2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CLCC1_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=hMCLC-1; IsoId=Q96S66-1; Sequence=Displayed; Name=2; Synonyms=hMCLC-2; IsoId=Q96S66-2; Sequence=VSP_027349; Name=3; Synonyms=hMCLC-3; IsoId=Q96S66-3; Sequence=VSP_027348; Name=4; Synonyms=hMCLC-4; IsoId=Q96S66-4; Sequence=VSP_027347; 
# AltName	CLCC1_HUMAN	Mid-1-related chloride channel protein 1
# BioGrid	116769	25
# CCDS	CCDS41362	-. [Q96S66-1]
# CCDS	CCDS60214	-. [Q96S66-4]
# CCDS	CCDS60215	-. [Q96S66-3]
# CCDS	CCDS793	-. [Q96S66-2]
# Ensembl	ENST00000302500	ENSP00000306552; ENSG00000121940. [Q96S66-3]
# Ensembl	ENST00000348264	ENSP00000337243; ENSG00000121940. [Q96S66-4]
# Ensembl	ENST00000356970	ENSP00000349456; ENSG00000121940. [Q96S66-1]
# Ensembl	ENST00000369968	ENSP00000358985; ENSG00000121940. [Q96S66-4]
# Ensembl	ENST00000369969	ENSP00000358986; ENSG00000121940. [Q96S66-3]
# Ensembl	ENST00000369970	ENSP00000358987; ENSG00000121940. [Q96S66-2]
# ExpressionAtlas	Q96S66	baseline and differential
# FUNCTION	CLCC1_HUMAN	Seems to act as a chloride ion channel. {ECO 0000250}. 
# GO_component	GO:0005634	nucleus; IEA:UniProtKB-SubCell.
# GO_component	GO:0005783	endoplasmic reticulum; IDA:HPA.
# GO_component	GO:0005794	Golgi apparatus; IEA:UniProtKB-SubCell.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_function	GO:0005254	chloride channel activity; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# Genevisible	Q96S66	HS
# HGNC	HGNC:29675	CLCC1
# IntAct	Q96S66	11
# InterPro	IPR009231	Chloride_chnl_CLIC-like
# Organism	CLCC1_HUMAN	Homo sapiens (Human)
# Pfam	PF05934	MCLC
# Proteomes	UP000005640	Chromosome 1
# RecName	CLCC1_HUMAN	Chloride channel CLIC-like protein 1
# RefSeq	NP_001041675	NM_001048210.2. [Q96S66-1]
# RefSeq	NP_001265131	NM_001278202.1. [Q96S66-3]
# RefSeq	NP_001265132	NM_001278203.1. [Q96S66-4]
# RefSeq	NP_055942	NM_015127.4. [Q96S66-2]
# SIMILARITY	Belongs to the chloride channel MCLC family. {ECO	0000305}.
# SUBCELLULAR LOCATION	CLCC1_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. Endoplasmic reticulum. Golgi apparatus. Nucleus {ECO 0000250}. 
# TCDB	1.A.36.1	the intracellular chloride channel (icc) family
# UCSC	uc009wes	human. [Q96S66-1]
# eggNOG	ENOG410IJAP	Eukaryota
# eggNOG	ENOG41108E0	LUCA
BLAST	swissprot:CLCC1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CLCC1_HUMAN
COXPRESdb	23155	http://coxpresdb.jp/data/gene/23155.shtml
CleanEx	HS_CLCC1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CLCC1
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr070152u	http://dx.doi.org/10.1021/pr070152u
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/jbc.M100366200	http://dx.doi.org/10.1074/jbc.M100366200
DOI	10.1093/dnares/5.5.277	http://dx.doi.org/10.1093/dnares/5.5.277
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AB018304	http://www.ebi.ac.uk/ena/data/view/AB018304
EMBL	AB052915	http://www.ebi.ac.uk/ena/data/view/AB052915
EMBL	AB052916	http://www.ebi.ac.uk/ena/data/view/AB052916
EMBL	AB052917	http://www.ebi.ac.uk/ena/data/view/AB052917
EMBL	AB052918	http://www.ebi.ac.uk/ena/data/view/AB052918
EMBL	AL449266	http://www.ebi.ac.uk/ena/data/view/AL449266
EMBL	AL449266	http://www.ebi.ac.uk/ena/data/view/AL449266
EMBL	AL449266	http://www.ebi.ac.uk/ena/data/view/AL449266
EMBL	AL449266	http://www.ebi.ac.uk/ena/data/view/AL449266
EMBL	BC002939	http://www.ebi.ac.uk/ena/data/view/BC002939
EMBL	CH471122	http://www.ebi.ac.uk/ena/data/view/CH471122
EMBL	CH471122	http://www.ebi.ac.uk/ena/data/view/CH471122
Ensembl	ENST00000302500	http://www.ensembl.org/id/ENST00000302500
Ensembl	ENST00000348264	http://www.ensembl.org/id/ENST00000348264
Ensembl	ENST00000356970	http://www.ensembl.org/id/ENST00000356970
Ensembl	ENST00000369968	http://www.ensembl.org/id/ENST00000369968
Ensembl	ENST00000369969	http://www.ensembl.org/id/ENST00000369969
Ensembl	ENST00000369970	http://www.ensembl.org/id/ENST00000369970
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GeneCards	CLCC1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CLCC1
GeneID	23155	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23155
GeneTree	ENSGT00390000016611	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000016611
HGNC	HGNC:29675	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:29675
HOGENOM	HOG000231351	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231351&db=HOGENOM6
HOVERGEN	HBG060364	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG060364&db=HOVERGEN
HPA	HPA009087	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA009087
HPA	HPA013210	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA013210
InParanoid	Q96S66	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96S66
IntAct	Q96S66	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96S66*
InterPro	IPR009231	http://www.ebi.ac.uk/interpro/entry/IPR009231
Jabion	23155	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=23155
KEGG_Gene	hsa:23155	http://www.genome.jp/dbget-bin/www_bget?hsa:23155
OMA	TGSIWEW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TGSIWEW
OrthoDB	EOG091G0BRS	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0BRS
PSORT	swissprot:CLCC1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CLCC1_HUMAN
PSORT-B	swissprot:CLCC1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CLCC1_HUMAN
PSORT2	swissprot:CLCC1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CLCC1_HUMAN
Pfam	PF05934	http://pfam.xfam.org/family/PF05934
PharmGKB	PA142672105	http://www.pharmgkb.org/do/serve?objId=PA142672105&objCls=Gene
Phobius	swissprot:CLCC1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CLCC1_HUMAN
PhylomeDB	Q96S66	http://phylomedb.org/?seqid=Q96S66
ProteinModelPortal	Q96S66	http://www.proteinmodelportal.org/query/uniprot/Q96S66
PubMed	11279057	http://www.ncbi.nlm.nih.gov/pubmed/11279057
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	17924679	http://www.ncbi.nlm.nih.gov/pubmed/17924679
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	9872452	http://www.ncbi.nlm.nih.gov/pubmed/9872452
RefSeq	NP_001041675	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001041675
RefSeq	NP_001265131	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001265131
RefSeq	NP_001265132	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001265132
RefSeq	NP_055942	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055942
STRING	9606.ENSP00000349456	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000349456&targetmode=cogs
TCDB	1.A.36.1	http://www.tcdb.org/search/result.php?tc=1.A.36.1
UCSC	uc009wes	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc009wes&org=rat
UniGene	Hs.658489	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.658489
UniProtKB	CLCC1_HUMAN	http://www.uniprot.org/uniprot/CLCC1_HUMAN
UniProtKB-AC	Q96S66	http://www.uniprot.org/uniprot/Q96S66
charge	swissprot:CLCC1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CLCC1_HUMAN
eggNOG	ENOG410IJAP	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IJAP
eggNOG	ENOG41108E0	http://eggnogapi.embl.de/nog_data/html/tree/ENOG41108E0
epestfind	swissprot:CLCC1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CLCC1_HUMAN
garnier	swissprot:CLCC1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CLCC1_HUMAN
helixturnhelix	swissprot:CLCC1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLCC1_HUMAN
hmoment	swissprot:CLCC1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CLCC1_HUMAN
iep	swissprot:CLCC1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CLCC1_HUMAN
inforesidue	swissprot:CLCC1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CLCC1_HUMAN
neXtProt	NX_Q96S66	http://www.nextprot.org/db/entry/NX_Q96S66
octanol	swissprot:CLCC1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CLCC1_HUMAN
pepcoil	swissprot:CLCC1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CLCC1_HUMAN
pepdigest	swissprot:CLCC1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CLCC1_HUMAN
pepinfo	swissprot:CLCC1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CLCC1_HUMAN
pepnet	swissprot:CLCC1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CLCC1_HUMAN
pepstats	swissprot:CLCC1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CLCC1_HUMAN
pepwheel	swissprot:CLCC1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CLCC1_HUMAN
pepwindow	swissprot:CLCC1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CLCC1_HUMAN
sigcleave	swissprot:CLCC1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CLCC1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SC6A2_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P23975-1; Sequence=Displayed; Name=2; IsoId=P23975-2; Sequence=VSP_044479; Name=3; IsoId=P23975-3; Sequence=VSP_054119; 
# AltName	SC6A2_HUMAN	Norepinephrine transporter
# AltName	SC6A2_HUMAN	Solute carrier family 6 member 2
# BioGrid	112421	3
# CCDS	CCDS10754	-. [P23975-1]
# CCDS	CCDS54011	-. [P23975-2]
# CCDS	CCDS58463	-. [P23975-3]
# ChiTaRS	SLC6A2	human
# DISEASE	SC6A2_HUMAN	Orthostatic intolerance (OI) [MIM 604715]  Syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. It is associated with postural tachycardia. Plasma norepinephrine concentration is abnormally high. {ECO 0000269|PubMed 10684912}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00182	Amphetamine
# DrugBank	DB00191	Phentermine
# DrugBank	DB00193	Tramadol
# DrugBank	DB00215	Citalopram
# DrugBank	DB00226	Guanadrel
# DrugBank	DB00234	Reboxetine
# DrugBank	DB00285	Venlafaxine
# DrugBank	DB00289	Atomoxetine
# DrugBank	DB00321	Amitriptyline
# DrugBank	DB00344	Protriptyline
# DrugBank	DB00368	Norepinephrine
# DrugBank	DB00370	Mirtazapine
# DrugBank	DB00408	Loxapine
# DrugBank	DB00422	Methylphenidate
# DrugBank	DB00454	Pethidine
# DrugBank	DB00458	Imipramine
# DrugBank	DB00476	Duloxetine
# DrugBank	DB00514	Dextromethorphan
# DrugBank	DB00540	Nortriptyline
# DrugBank	DB00543	Amoxapine
# DrugBank	DB00579	Mazindol
# DrugBank	DB00696	Ergotamine
# DrugBank	DB00715	Paroxetine
# DrugBank	DB00726	Trimipramine
# DrugBank	DB00830	Phenmetrazine
# DrugBank	DB00852	Pseudoephedrine
# DrugBank	DB00907	Cocaine
# DrugBank	DB00934	Maprotiline
# DrugBank	DB00937	Diethylpropion
# DrugBank	DB00988	Dopamine
# DrugBank	DB01105	Sibutramine
# DrugBank	DB01114	Chlorphenamine
# DrugBank	DB01142	Doxepin
# DrugBank	DB01149	Nefazodone
# DrugBank	DB01151	Desipramine
# DrugBank	DB01156	Bupropion
# DrugBank	DB01170	Guanethidine
# DrugBank	DB01173	Orphenadrine
# DrugBank	DB01175	Escitalopram
# DrugBank	DB01221	Ketamine
# DrugBank	DB01242	Clomipramine
# DrugBank	DB01363	Ephedra
# DrugBank	DB01364	Ephedrine
# DrugBank	DB01381	Ginkgo biloba
# DrugBank	DB01576	Dextroamphetamine
# DrugBank	DB01577	Methamphetamine
# DrugBank	DB01579	Phendimetrazine
# DrugBank	DB04840	Debrisoquin
# DrugBank	DB04896	Milnacipran
# DrugBank	DB06148	Mianserin
# DrugBank	DB06204	Tapentadol
# DrugBank	DB06262	Droxidopa
# DrugBank	DB06700	Desvenlafaxine
# DrugBank	DB06701	Dexmethylphenidate
# DrugBank	DB06704	Iobenguane
# DrugBank	DB06707	Levonordefrin
# DrugBank	DB08918	Levomilnacipran
# Ensembl	ENST00000219833	ENSP00000219833; ENSG00000103546. [P23975-2]
# Ensembl	ENST00000379906	ENSP00000369237; ENSG00000103546. [P23975-1]
# Ensembl	ENST00000567238	ENSP00000457375; ENSG00000103546. [P23975-3]
# Ensembl	ENST00000568943	ENSP00000457473; ENSG00000103546. [P23975-1]
# ExpressionAtlas	P23975	baseline and differential
# FUNCTION	SC6A2_HUMAN	Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals. {ECO 0000269|PubMed 2008212}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0009986	cell surface; IEA:Ensembl.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0043005	neuron projection; IBA:GO_Central.
# GO_component	GO:0045121	membrane raft; IEA:Ensembl.
# GO_function	GO:0008504	monoamine transmembrane transporter activity; IDA:MGI.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_function	SC6A2_HUMAN	GO 0005334 norepinephrine sodium symporter activity; TAS Reactome.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:ProtInc.
# GO_process	GO:0015844	monoamine transport; IDA:MGI.
# GO_process	GO:0015874	norepinephrine transport; IBA:GO_Central.
# GO_process	GO:0042493	response to drug; IEA:Ensembl.
# GO_process	GO:0048265	response to pain; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# Genevisible	P23975	HS
# HGNC	HGNC:11048	SLC6A2
# InterPro	IPR000175	Na/ntran_symport
# InterPro	IPR002435	Na/ntran_symport_noradrenaline
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H01031	[Nervous system disease] Postural tachycardia syndrome (POTS)
# MIM	163970	gene
# MIM	604715	phenotype
# MISCELLANEOUS	SC6A2_HUMAN	This protein is the target of psychomotor stimulants such as amphetamines or cocaine. 
# Organism	SC6A2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11616	PTHR11616
# PIR	S14278	S14278
# PRINTS	PR00176	NANEUSMPORT
# PRINTS	PR01201	NORTRANSPORT
# PROSITE	PS00610	NA_NEUROTRAN_SYMP_1
# PROSITE	PS00754	NA_NEUROTRAN_SYMP_2
# PROSITE	PS50267	NA_NEUROTRAN_SYMP_3
# Pfam	PF00209	SNF
# Proteomes	UP000005640	Chromosome 16
# Reactome	R-HSA-442660	Na+/Cl- dependent neurotransmitter transporters
# RecName	SC6A2_HUMAN	Sodium-dependent noradrenaline transporter
# RefSeq	NP_001034	NM_001043.3. [P23975-1]
# RefSeq	NP_001165972	NM_001172501.1. [P23975-1]
# RefSeq	NP_001165973	NM_001172502.1. [P23975-3]
# RefSeq	NP_001165975	NM_001172504.1. [P23975-2]
# RefSeq	XP_006721326	XM_006721263.2. [P23975-2]
# RefSeq	XP_011521597	XM_011523295.1. [P23975-2]
# SIMILARITY	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A2 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	SC6A2_HUMAN	Cell membrane {ECO 0000269|PubMed 2008212}; Multi-pass membrane protein {ECO 0000250|UniProtKB Q7K4Y6}. 
# SUBUNIT	Interacts with PRKCABP. {ECO:0000269|PubMed	11343649}. 
# TCDB	2.A.22.1:the neurotransmitter	sodium symporter (nss) family
# UCSC	uc002eif	human. [P23975-1]
# eggNOG	COG0733	LUCA
# eggNOG	KOG3659	Eukaryota
BLAST	swissprot:SC6A2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SC6A2_HUMAN
BioCyc	ZFISH:ENSG00000103546-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000103546-MONOMER
COXPRESdb	6530	http://coxpresdb.jp/data/gene/6530.shtml
CleanEx	HS_NAT1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_NAT1
CleanEx	HS_NET1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_NET1
CleanEx	HS_SLC6A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC6A2
CleanEx	HS_SLC6A5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC6A5
DOI	10.1006/bbrc.1995.2582	http://dx.doi.org/10.1006/bbrc.1995.2582
DOI	10.1016/S0896-6273(01)00267-7	http://dx.doi.org/10.1016/S0896-6273(01)00267-7
DOI	10.1038/350350a0	http://dx.doi.org/10.1038/350350a0
DOI	10.1038/nature03187	http://dx.doi.org/10.1038/nature03187
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1056/NEJM200002243420803	http://dx.doi.org/10.1056/NEJM200002243420803
DrugBank	DB00182	http://www.drugbank.ca/drugs/DB00182
DrugBank	DB00191	http://www.drugbank.ca/drugs/DB00191
DrugBank	DB00193	http://www.drugbank.ca/drugs/DB00193
DrugBank	DB00215	http://www.drugbank.ca/drugs/DB00215
DrugBank	DB00226	http://www.drugbank.ca/drugs/DB00226
DrugBank	DB00234	http://www.drugbank.ca/drugs/DB00234
DrugBank	DB00285	http://www.drugbank.ca/drugs/DB00285
DrugBank	DB00289	http://www.drugbank.ca/drugs/DB00289
DrugBank	DB00321	http://www.drugbank.ca/drugs/DB00321
DrugBank	DB00344	http://www.drugbank.ca/drugs/DB00344
DrugBank	DB00368	http://www.drugbank.ca/drugs/DB00368
DrugBank	DB00370	http://www.drugbank.ca/drugs/DB00370
DrugBank	DB00408	http://www.drugbank.ca/drugs/DB00408
DrugBank	DB00422	http://www.drugbank.ca/drugs/DB00422
DrugBank	DB00454	http://www.drugbank.ca/drugs/DB00454
DrugBank	DB00458	http://www.drugbank.ca/drugs/DB00458
DrugBank	DB00476	http://www.drugbank.ca/drugs/DB00476
DrugBank	DB00514	http://www.drugbank.ca/drugs/DB00514
DrugBank	DB00540	http://www.drugbank.ca/drugs/DB00540
DrugBank	DB00543	http://www.drugbank.ca/drugs/DB00543
DrugBank	DB00579	http://www.drugbank.ca/drugs/DB00579
DrugBank	DB00696	http://www.drugbank.ca/drugs/DB00696
DrugBank	DB00715	http://www.drugbank.ca/drugs/DB00715
DrugBank	DB00726	http://www.drugbank.ca/drugs/DB00726
DrugBank	DB00830	http://www.drugbank.ca/drugs/DB00830
DrugBank	DB00852	http://www.drugbank.ca/drugs/DB00852
DrugBank	DB00907	http://www.drugbank.ca/drugs/DB00907
DrugBank	DB00934	http://www.drugbank.ca/drugs/DB00934
DrugBank	DB00937	http://www.drugbank.ca/drugs/DB00937
DrugBank	DB00988	http://www.drugbank.ca/drugs/DB00988
DrugBank	DB01105	http://www.drugbank.ca/drugs/DB01105
DrugBank	DB01114	http://www.drugbank.ca/drugs/DB01114
DrugBank	DB01142	http://www.drugbank.ca/drugs/DB01142
DrugBank	DB01149	http://www.drugbank.ca/drugs/DB01149
DrugBank	DB01151	http://www.drugbank.ca/drugs/DB01151
DrugBank	DB01156	http://www.drugbank.ca/drugs/DB01156
DrugBank	DB01170	http://www.drugbank.ca/drugs/DB01170
DrugBank	DB01173	http://www.drugbank.ca/drugs/DB01173
DrugBank	DB01175	http://www.drugbank.ca/drugs/DB01175
DrugBank	DB01221	http://www.drugbank.ca/drugs/DB01221
DrugBank	DB01242	http://www.drugbank.ca/drugs/DB01242
DrugBank	DB01363	http://www.drugbank.ca/drugs/DB01363
DrugBank	DB01364	http://www.drugbank.ca/drugs/DB01364
DrugBank	DB01381	http://www.drugbank.ca/drugs/DB01381
DrugBank	DB01576	http://www.drugbank.ca/drugs/DB01576
DrugBank	DB01577	http://www.drugbank.ca/drugs/DB01577
DrugBank	DB01579	http://www.drugbank.ca/drugs/DB01579
DrugBank	DB04840	http://www.drugbank.ca/drugs/DB04840
DrugBank	DB04896	http://www.drugbank.ca/drugs/DB04896
DrugBank	DB06148	http://www.drugbank.ca/drugs/DB06148
DrugBank	DB06204	http://www.drugbank.ca/drugs/DB06204
DrugBank	DB06262	http://www.drugbank.ca/drugs/DB06262
DrugBank	DB06700	http://www.drugbank.ca/drugs/DB06700
DrugBank	DB06701	http://www.drugbank.ca/drugs/DB06701
DrugBank	DB06704	http://www.drugbank.ca/drugs/DB06704
DrugBank	DB06707	http://www.drugbank.ca/drugs/DB06707
DrugBank	DB08918	http://www.drugbank.ca/drugs/DB08918
EMBL	AC136621	http://www.ebi.ac.uk/ena/data/view/AC136621
EMBL	AK301811	http://www.ebi.ac.uk/ena/data/view/AK301811
EMBL	AK312793	http://www.ebi.ac.uk/ena/data/view/AK312793
EMBL	CH471092	http://www.ebi.ac.uk/ena/data/view/CH471092
EMBL	CH471092	http://www.ebi.ac.uk/ena/data/view/CH471092
EMBL	CH471092	http://www.ebi.ac.uk/ena/data/view/CH471092
EMBL	M65105	http://www.ebi.ac.uk/ena/data/view/M65105
EMBL	X91117	http://www.ebi.ac.uk/ena/data/view/X91117
EMBL	X91117	http://www.ebi.ac.uk/ena/data/view/X91117
EMBL	X91118	http://www.ebi.ac.uk/ena/data/view/X91118
EMBL	X91118	http://www.ebi.ac.uk/ena/data/view/X91118
EMBL	X91119	http://www.ebi.ac.uk/ena/data/view/X91119
EMBL	X91119	http://www.ebi.ac.uk/ena/data/view/X91119
EMBL	X91120	http://www.ebi.ac.uk/ena/data/view/X91120
EMBL	X91120	http://www.ebi.ac.uk/ena/data/view/X91120
EMBL	X91121	http://www.ebi.ac.uk/ena/data/view/X91121
EMBL	X91121	http://www.ebi.ac.uk/ena/data/view/X91121
EMBL	X91122	http://www.ebi.ac.uk/ena/data/view/X91122
EMBL	X91122	http://www.ebi.ac.uk/ena/data/view/X91122
EMBL	X91123	http://www.ebi.ac.uk/ena/data/view/X91123
EMBL	X91123	http://www.ebi.ac.uk/ena/data/view/X91123
EMBL	X91124	http://www.ebi.ac.uk/ena/data/view/X91124
EMBL	X91124	http://www.ebi.ac.uk/ena/data/view/X91124
EMBL	X91125	http://www.ebi.ac.uk/ena/data/view/X91125
EMBL	X91125	http://www.ebi.ac.uk/ena/data/view/X91125
EMBL	X91126	http://www.ebi.ac.uk/ena/data/view/X91126
EMBL	X91126	http://www.ebi.ac.uk/ena/data/view/X91126
EMBL	X91127	http://www.ebi.ac.uk/ena/data/view/X91127
EMBL	X91127	http://www.ebi.ac.uk/ena/data/view/X91127
Ensembl	ENST00000219833	http://www.ensembl.org/id/ENST00000219833
Ensembl	ENST00000379906	http://www.ensembl.org/id/ENST00000379906
Ensembl	ENST00000567238	http://www.ensembl.org/id/ENST00000567238
Ensembl	ENST00000568943	http://www.ensembl.org/id/ENST00000568943
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0043005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043005
GO_component	GO:0045121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045121
GO_function	GO:0005334	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005334
GO_function	GO:0008504	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008504
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0015844	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015844
GO_process	GO:0015874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015874
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0048265	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048265
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	SLC6A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC6A2
GeneID	6530	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6530
GeneTree	ENSGT00760000118857	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118857
HGNC	HGNC:11048	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11048
HOGENOM	HOG000116406	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116406&db=HOGENOM6
HOVERGEN	HBG071421	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG071421&db=HOVERGEN
InParanoid	P23975	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23975
InterPro	IPR000175	http://www.ebi.ac.uk/interpro/entry/IPR000175
InterPro	IPR002435	http://www.ebi.ac.uk/interpro/entry/IPR002435
Jabion	6530	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6530
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H01031	http://www.genome.jp/dbget-bin/www_bget?H01031
KEGG_Gene	hsa:6530	http://www.genome.jp/dbget-bin/www_bget?hsa:6530
KEGG_Orthology	KO:K05035	http://www.genome.jp/dbget-bin/www_bget?KO:K05035
MIM	163970	http://www.ncbi.nlm.nih.gov/omim/163970
MIM	604715	http://www.ncbi.nlm.nih.gov/omim/604715
MINT	MINT-197872	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-197872
OMA	PPWANWV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PPWANWV
OrthoDB	EOG091G08PX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08PX
PANTHER	PTHR11616	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11616
PRINTS	PR00176	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00176
PRINTS	PR01201	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01201
PROSITE	PS00610	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00610
PROSITE	PS00754	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00754
PROSITE	PS50267	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50267
PSORT	swissprot:SC6A2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SC6A2_HUMAN
PSORT-B	swissprot:SC6A2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SC6A2_HUMAN
PSORT2	swissprot:SC6A2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SC6A2_HUMAN
Pfam	PF00209	http://pfam.xfam.org/family/PF00209
PharmGKB	PA310	http://www.pharmgkb.org/do/serve?objId=PA310&objCls=Gene
Phobius	swissprot:SC6A2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SC6A2_HUMAN
PhylomeDB	P23975	http://phylomedb.org/?seqid=P23975
ProteinModelPortal	P23975	http://www.proteinmodelportal.org/query/uniprot/P23975
PubMed	10684912	http://www.ncbi.nlm.nih.gov/pubmed/10684912
PubMed	11343649	http://www.ncbi.nlm.nih.gov/pubmed/11343649
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15616553	http://www.ncbi.nlm.nih.gov/pubmed/15616553
PubMed	2008212	http://www.ncbi.nlm.nih.gov/pubmed/2008212
PubMed	7488042	http://www.ncbi.nlm.nih.gov/pubmed/7488042
PubMed	9655936	http://www.ncbi.nlm.nih.gov/pubmed/9655936
Reactome	R-HSA-442660	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442660
RefSeq	NP_001034	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001034
RefSeq	NP_001165972	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001165972
RefSeq	NP_001165973	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001165973
RefSeq	NP_001165975	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001165975
RefSeq	XP_006721326	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006721326
RefSeq	XP_011521597	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011521597
STRING	9606.ENSP00000219833	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000219833&targetmode=cogs
TCDB	2.A.22.1	http://www.tcdb.org/search/result.php?tc=2.A.22.1
UCSC	uc002eif	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002eif&org=rat
UniGene	Hs.78036	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.78036
UniProtKB	SC6A2_HUMAN	http://www.uniprot.org/uniprot/SC6A2_HUMAN
UniProtKB-AC	P23975	http://www.uniprot.org/uniprot/P23975
charge	swissprot:SC6A2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SC6A2_HUMAN
eggNOG	COG0733	http://eggnogapi.embl.de/nog_data/html/tree/COG0733
eggNOG	KOG3659	http://eggnogapi.embl.de/nog_data/html/tree/KOG3659
epestfind	swissprot:SC6A2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SC6A2_HUMAN
garnier	swissprot:SC6A2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SC6A2_HUMAN
helixturnhelix	swissprot:SC6A2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SC6A2_HUMAN
hmoment	swissprot:SC6A2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SC6A2_HUMAN
iep	swissprot:SC6A2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SC6A2_HUMAN
inforesidue	swissprot:SC6A2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SC6A2_HUMAN
neXtProt	NX_P23975	http://www.nextprot.org/db/entry/NX_P23975
octanol	swissprot:SC6A2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SC6A2_HUMAN
pepcoil	swissprot:SC6A2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SC6A2_HUMAN
pepdigest	swissprot:SC6A2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SC6A2_HUMAN
pepinfo	swissprot:SC6A2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SC6A2_HUMAN
pepnet	swissprot:SC6A2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SC6A2_HUMAN
pepstats	swissprot:SC6A2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SC6A2_HUMAN
pepwheel	swissprot:SC6A2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SC6A2_HUMAN
pepwindow	swissprot:SC6A2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SC6A2_HUMAN
sigcleave	swissprot:SC6A2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SC6A2_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	107560	6
# DrugBank	DB00184	Nicotine
# DrugBank	DB00674	Galantamine
# DrugBank	DB00898	Ethanol
# Ensembl	ENST00000299565	ENSP00000299565; ENSG00000169684
# ExpressionAtlas	P30532	baseline and differential
# FUNCTION	ACHA5_HUMAN	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005892	acetylcholine-gated channel complex; IC:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0004889	acetylcholine-activated cation-selective channel activity; NAS:UniProtKB.
# GO_function	GO:0015276	ligand-gated ion channel activity; TAS:DFLAT.
# GO_function	GO:0015464	acetylcholine receptor activity; IDA:UniProtKB.
# GO_process	GO:0006810	transport; NAS:ProtInc.
# GO_process	GO:0007165	signal transduction; NAS:UniProtKB.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:UniProtKB.
# GO_process	GO:0007271	synaptic transmission, cholinergic; IBA:GO_Central.
# GO_process	GO:0007274	neuromuscular synaptic transmission; IBA:GO_Central.
# GO_process	GO:0035095	behavioral response to nicotine; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.20.120.370	-; 2.
# Gene3D	2.70.170.10	-; 1.
# Genevisible	P30532	HS
# HGNC	HGNC:1959	CHRNA5
# INTERACTION	ACHA5_HUMAN	P17787 CHRNB2; NbExp=3; IntAct=EBI-6657490, EBI-9008612; 
# IntAct	P30532	3
# InterPro	IPR002394	Nicotinic_acetylcholine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# InterPro	IPR027361	Acetylcholine_rcpt_TM
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# MIM	118505	gene
# MIM	612052	phenotype
# Organism	ACHA5_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR18945	PTHR18945
# PIR	A38223	A38223
# POLYMORPHISM	Genetic variations in CHRNA5 have been associated with susceptibility to smoking-related behavioral traits and lung cancer, contributing to the smoking quantitative trait locus 3 (SQTL3) [MIM	612052]. 
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00254	NICOTINICR
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb; 2
# Proteomes	UP000005640	Chromosome 15
# Reactome	R-HSA-629594	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
# Reactome	R-HSA-629597	Highly calcium permeable nicotinic acetylcholine receptors
# RecName	ACHA5_HUMAN	Neuronal acetylcholine receptor subunit alpha-5
# RefSeq	NP_000736	NM_000745.3
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 5/CHRNA5 sub-subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	ACHA5_HUMAN	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Neuronal AChR seems to be composed of two different type of subunits	 alpha and non-alpha (beta). 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TIGRFAMs	TIGR00860	LIC
# UCSC	uc002bdy	human
# eggNOG	ENOG410XQGR	LUCA
# eggNOG	KOG3645	Eukaryota
BLAST	swissprot:ACHA5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ACHA5_HUMAN
BioCyc	ZFISH:ENSG00000169684-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000169684-MONOMER
COXPRESdb	1138	http://coxpresdb.jp/data/gene/1138.shtml
CleanEx	HS_CHRNA5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CHRNA5
DOI	10.1007/BF02736842	http://dx.doi.org/10.1007/BF02736842
DOI	10.1016/S0014-5793(96)01383-X	http://dx.doi.org/10.1016/S0014-5793(96)01383-X
DOI	10.1038/452537a	http://dx.doi.org/10.1038/452537a
DOI	10.1038/nature06885	http://dx.doi.org/10.1038/nature06885
DOI	10.1038/ng.109	http://dx.doi.org/10.1038/ng.109
DOI	10.1073/pnas.89.5.1572	http://dx.doi.org/10.1073/pnas.89.5.1572
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00184	http://www.drugbank.ca/drugs/DB00184
DrugBank	DB00674	http://www.drugbank.ca/drugs/DB00674
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
EMBL	AJ306481	http://www.ebi.ac.uk/ena/data/view/AJ306481
EMBL	AJ306482	http://www.ebi.ac.uk/ena/data/view/AJ306482
EMBL	AJ306483	http://www.ebi.ac.uk/ena/data/view/AJ306483
EMBL	AJ306484	http://www.ebi.ac.uk/ena/data/view/AJ306484
EMBL	AJ306485	http://www.ebi.ac.uk/ena/data/view/AJ306485
EMBL	AJ306486	http://www.ebi.ac.uk/ena/data/view/AJ306486
EMBL	BC033639	http://www.ebi.ac.uk/ena/data/view/BC033639
EMBL	M83712	http://www.ebi.ac.uk/ena/data/view/M83712
EMBL	U62434	http://www.ebi.ac.uk/ena/data/view/U62434
EMBL	Y08419	http://www.ebi.ac.uk/ena/data/view/Y08419
Ensembl	ENST00000299565	http://www.ensembl.org/id/ENST00000299565
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005892	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005892
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0004889	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004889
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_function	GO:0015464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015464
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007271
GO_process	GO:0007274	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007274
GO_process	GO:0035095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035095
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.20.120.370	http://www.cathdb.info/version/latest/superfamily/1.20.120.370
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	CHRNA5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CHRNA5
GeneID	1138	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1138
GeneTree	ENSGT00760000118930	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118930
HGNC	HGNC:1959	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1959
HOGENOM	HOG000006756	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006756&db=HOGENOM6
HOVERGEN	HBG003756	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003756&db=HOVERGEN
HPA	HPA054381	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA054381
InParanoid	P30532	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30532
IntAct	P30532	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30532*
InterPro	IPR002394	http://www.ebi.ac.uk/interpro/entry/IPR002394
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
InterPro	IPR027361	http://www.ebi.ac.uk/interpro/entry/IPR027361
Jabion	1138	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1138
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:1138	http://www.genome.jp/dbget-bin/www_bget?hsa:1138
KEGG_Orthology	KO:K04807	http://www.genome.jp/dbget-bin/www_bget?KO:K04807
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
MIM	118505	http://www.ncbi.nlm.nih.gov/omim/118505
MIM	612052	http://www.ncbi.nlm.nih.gov/omim/612052
OMA	SIAKHED	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SIAKHED
OrthoDB	EOG091G0R20	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0R20
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00254	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00254
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:ACHA5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ACHA5_HUMAN
PSORT-B	swissprot:ACHA5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ACHA5_HUMAN
PSORT2	swissprot:ACHA5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ACHA5_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA26491	http://www.pharmgkb.org/do/serve?objId=PA26491&objCls=Gene
Phobius	swissprot:ACHA5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ACHA5_HUMAN
PhylomeDB	P30532	http://phylomedb.org/?seqid=P30532
ProteinModelPortal	P30532	http://www.proteinmodelportal.org/query/uniprot/P30532
PubMed	1542648	http://www.ncbi.nlm.nih.gov/pubmed/1542648
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18385676	http://www.ncbi.nlm.nih.gov/pubmed/18385676
PubMed	18385720	http://www.ncbi.nlm.nih.gov/pubmed/18385720
PubMed	18385738	http://www.ncbi.nlm.nih.gov/pubmed/18385738
PubMed	8906617	http://www.ncbi.nlm.nih.gov/pubmed/8906617
PubMed	9009220	http://www.ncbi.nlm.nih.gov/pubmed/9009220
Reactome	R-HSA-629594	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-629594
Reactome	R-HSA-629597	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-629597
RefSeq	NP_000736	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000736
SMR	P30532	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30532
STRING	9606.ENSP00000299565	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000299565&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc002bdy	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002bdy&org=rat
UniGene	Hs.1614	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.1614
UniGene	Hs.719767	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.719767
UniProtKB	ACHA5_HUMAN	http://www.uniprot.org/uniprot/ACHA5_HUMAN
UniProtKB-AC	P30532	http://www.uniprot.org/uniprot/P30532
charge	swissprot:ACHA5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ACHA5_HUMAN
eggNOG	ENOG410XQGR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQGR
eggNOG	KOG3645	http://eggnogapi.embl.de/nog_data/html/tree/KOG3645
epestfind	swissprot:ACHA5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ACHA5_HUMAN
garnier	swissprot:ACHA5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ACHA5_HUMAN
helixturnhelix	swissprot:ACHA5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACHA5_HUMAN
hmoment	swissprot:ACHA5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ACHA5_HUMAN
iep	swissprot:ACHA5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ACHA5_HUMAN
inforesidue	swissprot:ACHA5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ACHA5_HUMAN
neXtProt	NX_P30532	http://www.nextprot.org/db/entry/NX_P30532
octanol	swissprot:ACHA5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ACHA5_HUMAN
pepcoil	swissprot:ACHA5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ACHA5_HUMAN
pepdigest	swissprot:ACHA5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ACHA5_HUMAN
pepinfo	swissprot:ACHA5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ACHA5_HUMAN
pepnet	swissprot:ACHA5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ACHA5_HUMAN
pepstats	swissprot:ACHA5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ACHA5_HUMAN
pepwheel	swissprot:ACHA5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ACHA5_HUMAN
pepwindow	swissprot:ACHA5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ACHA5_HUMAN
sigcleave	swissprot:ACHA5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ACHA5_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AP1G1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O43747-1; Sequence=Displayed; Name=2; IsoId=O43747-2; Sequence=VSP_040133; 
# AltName	AP1G1_HUMAN	Adaptor protein complex AP-1 subunit gamma-1
# AltName	AP1G1_HUMAN	Adaptor-related protein complex 1 subunit gamma-1
# AltName	AP1G1_HUMAN	Clathrin assembly protein complex 1 gamma-1 large chain
# AltName	AP1G1_HUMAN	Gamma1-adaptin
# AltName	AP1G1_HUMAN	Golgi adaptor HA1/AP1 adaptin subunit gamma-1
# BioGrid	106673	50
# CCDS	CCDS32480	-. [O43747-1]
# CCDS	CCDS45522	-. [O43747-2]
# ChiTaRS	AP1G1	human
# Ensembl	ENST00000299980	ENSP00000299980; ENSG00000166747. [O43747-1]
# Ensembl	ENST00000393512	ENSP00000377148; ENSG00000166747. [O43747-2]
# Ensembl	ENST00000569748	ENSP00000454523; ENSG00000166747. [O43747-1]
# ExpressionAtlas	O43747	baseline and differential
# FUNCTION	AP1G1_HUMAN	Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. 
# GO_component	GO:0000139	Golgi membrane; TAS:Reactome.
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0005765	lysosomal membrane; TAS:Reactome.
# GO_component	GO:0005794	Golgi apparatus; IDA:UniProtKB.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0030119	AP-type membrane coat adaptor complex; TAS:ProtInc.
# GO_component	GO:0030131	clathrin adaptor complex; IEA:InterPro.
# GO_component	GO:0030136	clathrin-coated vesicle; IDA:MGI.
# GO_component	GO:0030659	cytoplasmic vesicle membrane; TAS:Reactome.
# GO_component	GO:0030665	clathrin-coated vesicle membrane; ISS:BHF-UCL.
# GO_component	GO:0030669	clathrin-coated endocytic vesicle membrane; TAS:Reactome.
# GO_component	GO:0032588	trans-Golgi network membrane; TAS:Reactome.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_component	GO:0055037	recycling endosome; IDA:UniProtKB.
# GO_function	GO:0005215	transporter activity; TAS:ProtInc.
# GO_function	GO:0008565	protein transporter activity; IEA:InterPro.
# GO_function	GO:0017137	Rab GTPase binding; IPI:ParkinsonsUK-UCL.
# GO_function	GO:0019894	kinesin binding; IPI:UniProtKB.
# GO_function	GO:0030742	GTP-dependent protein binding; IPI:ParkinsonsUK-UCL.
# GO_process	GO:0006886	intracellular protein transport; TAS:ProtInc.
# GO_process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
# GO_process	GO:0032438	melanosome organization; IC:ParkinsonsUK-UCL.
# GO_process	GO:0035646	endosome to melanosome transport; IMP:ParkinsonsUK-UCL.
# GO_process	GO:0043323	positive regulation of natural killer cell degranulation; IMP:UniProtKB.
# GO_process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity; IMP:UniProtKB.
# GO_process	GO:0050690	regulation of defense response to virus by virus; TAS:Reactome.
# GO_process	GO:0090160	Golgi to lysosome transport; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008092	cytoskeletal protein binding
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007034	vacuolar transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# Gene3D	1.25.10.10	-; 1.
# Gene3D	2.60.40.1230	-; 2.
# Genevisible	O43747	HS
# HGNC	HGNC:555	AP1G1
# INTERACTION	AP1G1_HUMAN	P56377 AP1S2; NbExp=5; IntAct=EBI-10185819, EBI-1054374; Q15276 RABEP1; NbExp=2; IntAct=EBI-447609, EBI-447043; Q96S82 UBL7; NbExp=5; IntAct=EBI-10185819, EBI-348604; 
# IntAct	O43747	28
# InterPro	IPR002553	Clathrin/coatomer_adapt-like_N
# InterPro	IPR008152	Clathrin_a/b/g-adaptin_app_Ig
# InterPro	IPR008153	Clathrin_g-adaptin_app
# InterPro	IPR011989	ARM-like
# InterPro	IPR013041	Coatomer/clathrin_app_Ig-like
# InterPro	IPR016024	ARM-type_fold
# InterPro	IPR017107	AP1_complex_gsu
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Pathway	ko04142	Lysosome
# MIM	603533	gene
# Organism	AP1G1_HUMAN	Homo sapiens (Human)
# PDB	1IU1	X-ray; 1.80 A; A/B=677-822
# PIRSF	PIRSF037094	AP1_complex_gamma
# PROSITE	PS50180	GAE
# Pfam	PF01602	Adaptin_N
# Pfam	PF02883	Alpha_adaptinC2
# Proteomes	UP000005640	Chromosome 16
# Reactome	R-HSA-164940	Nef mediated downregulation of MHC class I complex cell surface expression
# Reactome	R-HSA-2132295	MHC class II antigen presentation
# Reactome	R-HSA-432720	Lysosome Vesicle Biogenesis
# Reactome	R-HSA-432722	Golgi Associated Vesicle Biogenesis
# RecName	AP1G1_HUMAN	AP-1 complex subunit gamma-1
# RefSeq	NP_001025178	NM_001030007.1. [O43747-2]
# RefSeq	NP_001119	NM_001128.5. [O43747-1]
# SIMILARITY	Belongs to the adaptor complexes large subunit family. {ECO	0000305}. 
# SIMILARITY	Contains 1 GAE domain. {ECO:0000255|PROSITE- ProRule	PRU00093}.
# SMART	SM00809	Alpha_adaptinC2
# SUBCELLULAR LOCATION	AP1G1_HUMAN	Golgi apparatus {ECO 0000269|PubMed 12773381}. Cytoplasmic vesicle, clathrin- coated vesicle membrane {ECO 0000269|PubMed 12773381}; Peripheral membrane protein {ECO 0000269|PubMed 12773381}; Cytoplasmic side {ECO 0000269|PubMed 12773381}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. 
# SUBUNIT	AP1G1_HUMAN	Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta- type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). Binds RABEP1 and SYNRG. Interacts (via GAE domain) with AP1AR (via coiled-coil domain). {ECO 0000269|PubMed 12042876, ECO 0000269|PubMed 12773381, ECO 0000269|PubMed 15775984}. 
# SUPFAM	SSF48371	SSF48371
# SUPFAM	SSF49348	SSF49348
# TISSUE SPECIFICITY	AP1G1_HUMAN	Widely expressed. 
# UCSC	uc010cgg	human. [O43747-1]
# eggNOG	ENOG410XPKK	LUCA
# eggNOG	KOG1062	Eukaryota
BLAST	swissprot:AP1G1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AP1G1_HUMAN
BioCyc	ZFISH:ENSG00000166747-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000166747-MONOMER
COXPRESdb	164	http://coxpresdb.jp/data/gene/164.shtml
CleanEx	HS_AP1G1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AP1G1
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/geno.1998.5289	http://dx.doi.org/10.1006/geno.1998.5289
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature03187	http://dx.doi.org/10.1038/nature03187
DOI	10.1038/nsb808	http://dx.doi.org/10.1038/nsb808
DOI	10.1038/sj.emboj.7600600	http://dx.doi.org/10.1038/sj.emboj.7600600
DOI	10.1074/jbc.273.38.24693	http://dx.doi.org/10.1074/jbc.273.38.24693
DOI	10.1093/emboj/cdg257	http://dx.doi.org/10.1093/emboj/cdg257
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AB015317	http://www.ebi.ac.uk/ena/data/view/AB015317
EMBL	AC009097	http://www.ebi.ac.uk/ena/data/view/AC009097
EMBL	AC010653	http://www.ebi.ac.uk/ena/data/view/AC010653
EMBL	AJ224112	http://www.ebi.ac.uk/ena/data/view/AJ224112
EMBL	AJ224113	http://www.ebi.ac.uk/ena/data/view/AJ224113
EMBL	AJ224114	http://www.ebi.ac.uk/ena/data/view/AJ224114
EMBL	AL050025	http://www.ebi.ac.uk/ena/data/view/AL050025
EMBL	AL110198	http://www.ebi.ac.uk/ena/data/view/AL110198
EMBL	Y12226	http://www.ebi.ac.uk/ena/data/view/Y12226
Ensembl	ENST00000299980	http://www.ensembl.org/id/ENST00000299980
Ensembl	ENST00000393512	http://www.ensembl.org/id/ENST00000393512
Ensembl	ENST00000569748	http://www.ensembl.org/id/ENST00000569748
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0030119	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030119
GO_component	GO:0030131	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030131
GO_component	GO:0030136	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030136
GO_component	GO:0030659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030659
GO_component	GO:0030665	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030665
GO_component	GO:0030669	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030669
GO_component	GO:0032588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032588
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_component	GO:0055037	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055037
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0017137	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017137
GO_function	GO:0019894	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019894
GO_function	GO:0030742	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030742
GO_process	GO:0006886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006886
GO_process	GO:0019886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019886
GO_process	GO:0032438	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032438
GO_process	GO:0035646	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035646
GO_process	GO:0043323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043323
GO_process	GO:0045954	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045954
GO_process	GO:0050690	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050690
GO_process	GO:0090160	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090160
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007034	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007034
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
Gene3D	2.60.40.1230	http://www.cathdb.info/version/latest/superfamily/2.60.40.1230
GeneCards	AP1G1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=AP1G1
GeneID	164	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=164
GeneTree	ENSGT00390000012618	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000012618
HGNC	HGNC:555	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:555
HOGENOM	HOG000210271	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000210271&db=HOGENOM6
HOVERGEN	HBG067473	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG067473&db=HOVERGEN
HPA	CAB009049	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB009049
HPA	HPA041224	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA041224
InParanoid	O43747	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O43747
IntAct	O43747	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O43747*
InterPro	IPR002553	http://www.ebi.ac.uk/interpro/entry/IPR002553
InterPro	IPR008152	http://www.ebi.ac.uk/interpro/entry/IPR008152
InterPro	IPR008153	http://www.ebi.ac.uk/interpro/entry/IPR008153
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR013041	http://www.ebi.ac.uk/interpro/entry/IPR013041
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
InterPro	IPR017107	http://www.ebi.ac.uk/interpro/entry/IPR017107
Jabion	164	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=164
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Gene	hsa:164	http://www.genome.jp/dbget-bin/www_bget?hsa:164
KEGG_Orthology	KO:K12391	http://www.genome.jp/dbget-bin/www_bget?KO:K12391
KEGG_Pathway	ko04142	http://www.genome.jp/kegg-bin/show_pathway?ko04142
MIM	603533	http://www.ncbi.nlm.nih.gov/omim/603533
MINT	MINT-3369703	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3369703
OMA	FKSECAS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FKSECAS
OrthoDB	EOG091G01RV	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01RV
PDB	1IU1	http://www.ebi.ac.uk/pdbe-srv/view/entry/1IU1
PDBsum	1IU1	http://www.ebi.ac.uk/pdbsum/1IU1
PROSITE	PS50180	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50180
PSORT	swissprot:AP1G1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AP1G1_HUMAN
PSORT-B	swissprot:AP1G1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AP1G1_HUMAN
PSORT2	swissprot:AP1G1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AP1G1_HUMAN
Pfam	PF01602	http://pfam.xfam.org/family/PF01602
Pfam	PF02883	http://pfam.xfam.org/family/PF02883
PharmGKB	PA24845	http://www.pharmgkb.org/do/serve?objId=PA24845&objCls=Gene
Phobius	swissprot:AP1G1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AP1G1_HUMAN
PhylomeDB	O43747	http://phylomedb.org/?seqid=O43747
ProteinModelPortal	O43747	http://www.proteinmodelportal.org/query/uniprot/O43747
PubMed	12042876	http://www.ncbi.nlm.nih.gov/pubmed/12042876
PubMed	12773381	http://www.ncbi.nlm.nih.gov/pubmed/12773381
PubMed	15616553	http://www.ncbi.nlm.nih.gov/pubmed/15616553
PubMed	15775984	http://www.ncbi.nlm.nih.gov/pubmed/15775984
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	9653655	http://www.ncbi.nlm.nih.gov/pubmed/9653655
PubMed	9733768	http://www.ncbi.nlm.nih.gov/pubmed/9733768
Reactome	R-HSA-164940	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-164940
Reactome	R-HSA-2132295	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2132295
Reactome	R-HSA-432720	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432720
Reactome	R-HSA-432722	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432722
RefSeq	NP_001025178	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001025178
RefSeq	NP_001119	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001119
SMART	SM00809	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00809
SMR	O43747	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O43747
STRING	9606.ENSP00000377148	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000377148&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
SUPFAM	SSF49348	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49348
UCSC	uc010cgg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010cgg&org=rat
UniGene	Hs.461253	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.461253
UniProtKB	AP1G1_HUMAN	http://www.uniprot.org/uniprot/AP1G1_HUMAN
UniProtKB-AC	O43747	http://www.uniprot.org/uniprot/O43747
charge	swissprot:AP1G1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AP1G1_HUMAN
eggNOG	ENOG410XPKK	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPKK
eggNOG	KOG1062	http://eggnogapi.embl.de/nog_data/html/tree/KOG1062
epestfind	swissprot:AP1G1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AP1G1_HUMAN
garnier	swissprot:AP1G1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AP1G1_HUMAN
helixturnhelix	swissprot:AP1G1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AP1G1_HUMAN
hmoment	swissprot:AP1G1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AP1G1_HUMAN
iep	swissprot:AP1G1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AP1G1_HUMAN
inforesidue	swissprot:AP1G1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AP1G1_HUMAN
neXtProt	NX_O43747	http://www.nextprot.org/db/entry/NX_O43747
octanol	swissprot:AP1G1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AP1G1_HUMAN
pepcoil	swissprot:AP1G1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AP1G1_HUMAN
pepdigest	swissprot:AP1G1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AP1G1_HUMAN
pepinfo	swissprot:AP1G1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AP1G1_HUMAN
pepnet	swissprot:AP1G1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AP1G1_HUMAN
pepstats	swissprot:AP1G1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AP1G1_HUMAN
pepwheel	swissprot:AP1G1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AP1G1_HUMAN
pepwindow	swissprot:AP1G1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AP1G1_HUMAN
sigcleave	swissprot:AP1G1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AP1G1_HUMAN
## Database	ID	URL or Descriptions
# AltName	S6A17_HUMAN	Sodium-dependent neurotransmitter transporter NTT4
# AltName	S6A17_HUMAN	Solute carrier family 6 member 17
# DISEASE	S6A17_HUMAN	Mental retardation, autosomal recessive 48 (MRT48) [MIM 616269]  A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT48 patients show moderate to severe intellectual disability and additional features including progressive tremor, speech impairment, and sometimes behavioral problems. {ECO 0000269|PubMed 25704603}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000331565	ENSP00000330199; ENSG00000197106
# FUNCTION	S6A17_HUMAN	Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity). {ECO 0000250|UniProtKB P31662}. 
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0008021	synaptic vesicle; ISS:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030672	synaptic vesicle membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; IBA:GO_Central.
# GO_function	S6A17_HUMAN	GO 0005328 neurotransmitter sodium symporter activity; IEA InterPro.
# GO_process	GO:0007420	brain development; ISS:UniProtKB.
# GO_process	GO:0015804	neutral amino acid transport; ISS:UniProtKB.
# GO_process	GO:0015816	glycine transport; ISS:UniProtKB.
# GO_process	GO:0015820	leucine transport; ISS:UniProtKB.
# GO_process	GO:0015824	proline transport; ISS:UniProtKB.
# GO_process	GO:0032328	alanine transport; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0048856	anatomical structure development
# Genevisible	Q9H1V8	HS
# HGNC	HGNC:31399	SLC6A17
# InterPro	IPR000175	Na/ntran_symport
# InterPro	IPR002438	Na/ntran_symport_orphan
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Brite	ko04040	 Ion channels
# MIM	610299	gene
# MIM	616269	phenotype
# Organism	S6A17_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11616	PTHR11616; 2
# PRINTS	PR00176	NANEUSMPORT
# PRINTS	PR01206	ORPHTRNSPORT
# PROSITE	PS00610	NA_NEUROTRAN_SYMP_1
# PROSITE	PS00754	NA_NEUROTRAN_SYMP_2
# PROSITE	PS50267	NA_NEUROTRAN_SYMP_3
# Pfam	PF00209	SNF
# Proteomes	UP000005640	Chromosome 1
# RecName	S6A17_HUMAN	Sodium-dependent neutral amino acid transporter SLC6A17
# RefSeq	NP_001010898	NM_001010898.2
# RefSeq	XP_006710706	XM_006710643.2
# SIMILARITY	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A17 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	S6A17_HUMAN	Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO 0000250|UniProtKB P31662}; Multi- pass membrane protein {ECO 0000250|UniProtKB P31662}. Note=Localizes at synaptic junctions - at both pre- and post- synaptic sites - particularly in excitatory glutamatergic terminals. {ECO 0000250|UniProtKB Q8BJI1}. 
# TCDB	2.A.22.6:the neurotransmitter	sodium symporter (nss) family
# UCSC	uc009wfq	human
# eggNOG	COG0733	LUCA
# eggNOG	KOG3659	Eukaryota
BLAST	swissprot:S6A17_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S6A17_HUMAN
BioCyc	ZFISH:G66-31483-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31483-MONOMER
COXPRESdb	388662	http://coxpresdb.jp/data/gene/388662.shtml
CleanEx	HS_SLC6A17	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC6A17
DOI	10.1016/j.ajhg.2015.01.010	http://dx.doi.org/10.1016/j.ajhg.2015.01.010
DOI	10.1016/j.bbrc.2005.08.048	http://dx.doi.org/10.1016/j.bbrc.2005.08.048
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AK289982	http://www.ebi.ac.uk/ena/data/view/AK289982
EMBL	AL137790	http://www.ebi.ac.uk/ena/data/view/AL137790
EMBL	AL137790	http://www.ebi.ac.uk/ena/data/view/AL137790
EMBL	AL355990	http://www.ebi.ac.uk/ena/data/view/AL355990
EMBL	AL355990	http://www.ebi.ac.uk/ena/data/view/AL355990
EMBL	BC140908	http://www.ebi.ac.uk/ena/data/view/BC140908
Ensembl	ENST00000331565	http://www.ensembl.org/id/ENST00000331565
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0008021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008021
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030672	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030672
GO_function	GO:0005328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005328
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_process	GO:0007420	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007420
GO_process	GO:0015804	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015804
GO_process	GO:0015816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015816
GO_process	GO:0015820	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015820
GO_process	GO:0015824	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015824
GO_process	GO:0032328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032328
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GeneCards	SLC6A17	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC6A17
GeneID	388662	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=388662
GeneTree	ENSGT00760000119044	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119044
HGNC	HGNC:31399	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:31399
HOGENOM	HOG000116406	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116406&db=HOGENOM6
HOVERGEN	HBG071421	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG071421&db=HOVERGEN
HPA	HPA007663	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA007663
HPA	HPA008044	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA008044
InParanoid	Q9H1V8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9H1V8
InterPro	IPR000175	http://www.ebi.ac.uk/interpro/entry/IPR000175
InterPro	IPR002438	http://www.ebi.ac.uk/interpro/entry/IPR002438
Jabion	388662	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=388662
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:388662	http://www.genome.jp/dbget-bin/www_bget?hsa:388662
KEGG_Orthology	KO:K05048	http://www.genome.jp/dbget-bin/www_bget?KO:K05048
MIM	610299	http://www.ncbi.nlm.nih.gov/omim/610299
MIM	616269	http://www.ncbi.nlm.nih.gov/omim/616269
OMA	MEMYNVI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MEMYNVI
OrthoDB	EOG091G08PX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08PX
PANTHER	PTHR11616	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11616
PRINTS	PR00176	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00176
PRINTS	PR01206	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01206
PROSITE	PS00610	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00610
PROSITE	PS00754	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00754
PROSITE	PS50267	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50267
PSORT	swissprot:S6A17_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S6A17_HUMAN
PSORT-B	swissprot:S6A17_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S6A17_HUMAN
PSORT2	swissprot:S6A17_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S6A17_HUMAN
Pfam	PF00209	http://pfam.xfam.org/family/PF00209
PharmGKB	PA134941636	http://www.pharmgkb.org/do/serve?objId=PA134941636&objCls=Gene
Phobius	swissprot:S6A17_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S6A17_HUMAN
PhylomeDB	Q9H1V8	http://phylomedb.org/?seqid=Q9H1V8
ProteinModelPortal	Q9H1V8	http://www.proteinmodelportal.org/query/uniprot/Q9H1V8
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16125675	http://www.ncbi.nlm.nih.gov/pubmed/16125675
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	25704603	http://www.ncbi.nlm.nih.gov/pubmed/25704603
RefSeq	NP_001010898	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001010898
RefSeq	XP_006710706	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006710706
STRING	9606.ENSP00000330199	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000330199&targetmode=cogs
TCDB	2.A.22.6	http://www.tcdb.org/search/result.php?tc=2.A.22.6
UCSC	uc009wfq	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc009wfq&org=rat
UniGene	Hs.128382	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.128382
UniProtKB	S6A17_HUMAN	http://www.uniprot.org/uniprot/S6A17_HUMAN
UniProtKB-AC	Q9H1V8	http://www.uniprot.org/uniprot/Q9H1V8
charge	swissprot:S6A17_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S6A17_HUMAN
eggNOG	COG0733	http://eggnogapi.embl.de/nog_data/html/tree/COG0733
eggNOG	KOG3659	http://eggnogapi.embl.de/nog_data/html/tree/KOG3659
epestfind	swissprot:S6A17_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S6A17_HUMAN
garnier	swissprot:S6A17_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S6A17_HUMAN
helixturnhelix	swissprot:S6A17_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S6A17_HUMAN
hmoment	swissprot:S6A17_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S6A17_HUMAN
iep	swissprot:S6A17_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S6A17_HUMAN
inforesidue	swissprot:S6A17_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S6A17_HUMAN
neXtProt	NX_Q9H1V8	http://www.nextprot.org/db/entry/NX_Q9H1V8
octanol	swissprot:S6A17_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S6A17_HUMAN
pepcoil	swissprot:S6A17_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S6A17_HUMAN
pepdigest	swissprot:S6A17_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S6A17_HUMAN
pepinfo	swissprot:S6A17_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S6A17_HUMAN
pepnet	swissprot:S6A17_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S6A17_HUMAN
pepstats	swissprot:S6A17_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S6A17_HUMAN
pepwheel	swissprot:S6A17_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S6A17_HUMAN
pepwindow	swissprot:S6A17_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S6A17_HUMAN
sigcleave	swissprot:S6A17_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S6A17_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SCNNA_HUMAN	Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=Alpha ENAC1; IsoId=P37088-1; Sequence=Displayed; Name=2; Synonyms=Alpha ENAC2; IsoId=P37088-2; Sequence=VSP_007719; Name=3; Synonyms=Alpha ENACx; IsoId=P37088-3; Sequence=VSP_007720, VSP_007721; Note=Does not give rise to amiloride-sensitive ion current. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=4; Synonyms=Alpha ENAC-19; IsoId=P37088-4; Sequence=VSP_007722; Note=Amiloride-sensitive ion current is nearly abolished.; Name=5; Synonyms=Alpha ENAC+22; IsoId=P37088-5; Sequence=VSP_007723; Note=Does not give rise to amiloride-sensitive ion current.; Name=6; IsoId=P37088-6; Sequence=VSP_043667; Note=No experimental confirmation available.; 
# AltName	SCNNA_HUMAN	Alpha-NaCH
# AltName	SCNNA_HUMAN	Epithelial Na(+) channel subunit alpha
# AltName	SCNNA_HUMAN	Nonvoltage-gated sodium channel 1 subunit alpha
# AltName	SCNNA_HUMAN	SCNEA
# BioGrid	112241	21
# CCDS	CCDS53738	-. [P37088-2]
# CCDS	CCDS53739	-. [P37088-6]
# CCDS	CCDS8543	-. [P37088-1]
# ChiTaRS	SCNN1A	human
# DISEASE	SCNNA_HUMAN	Bronchiectasis with or without elevated sweat chloride 2 (BESC2) [MIM 613021]  A debilitating respiratory disease characterized by chronic, abnormal dilatation of the bronchi and other cystic fibrosis-like symptoms in the absence of known causes of bronchiectasis (cystic fibrosis, autoimmune diseases, ciliary dyskinesia, common variable immunodeficiency, foreign body obstruction). Clinical features include sub-normal lung function, sinopulmonary infections, chronic productive cough, excessive sputum production, and elevated sweat chloride in some cases. {ECO 0000269|PubMed 19462466}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCNNA_HUMAN	Pseudohypoaldosteronism 1, autosomal recessive (PHA1B) [MIM 264350]  A rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. PHA1B is a severe form involving multiple organ systems, and characterized by an often fulminant presentation in the neonatal period with dehydration, hyponatremia, hyperkalemia, metabolic acidosis, failure to thrive and weight loss. {ECO 0000269|PubMed 10586178, ECO 0000269|PubMed 15853823, ECO 0000269|PubMed 18634878}. Note=The disease is caused by mutations affecting the gene represented in this entry. The degree of channel function impairment differentially affects the renin-aldosterone system and urinary Na/K ratios, resulting in distinct genotype-phenotype relationships in PHA1 patients. Loss-of-function mutations are associated with a severe clinical course and age-dependent hyperactivation of the renin-aldosterone system. This feature is not observed in patients with missense mutations that reduce but do not eliminate channel function. Markedly reduced channel activity results in impaired linear growth and delayed puberty (PubMed 18634878). {ECO 0000269|PubMed 18634878}. 
# DrugBank	DB00384	Triamterene
# DrugBank	DB00594	Amiloride
# ENZYME REGULATION	Activated by WNK1, WNK2, WNK3 and WNK4. {ECO:0000250|UniProtKB	Q61180}. 
# Ensembl	ENST00000228916	ENSP00000228916; ENSG00000111319. [P37088-1]
# Ensembl	ENST00000360168	ENSP00000353292; ENSG00000111319. [P37088-2]
# Ensembl	ENST00000543768	ENSP00000438739; ENSG00000111319. [P37088-6]
# ExpressionAtlas	P37088	baseline and differential
# FUNCTION	SCNNA_HUMAN	Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. {ECO 0000269|PubMed 24124190, ECO 0000269|PubMed 8278374}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_component	GO:0031514	motile cilium; IDA:UniProtKB.
# GO_component	GO:0034706	sodium channel complex; IDA:UniProtKB.
# GO_component	GO:0060170	ciliary membrane; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0015280	ligand-gated sodium channel activity; IEA:InterPro.
# GO_function	GO:0050699	WW domain binding; IPI:BHF-UCL.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0035725	sodium ion transmembrane transport; IDA:UniProtKB.
# GO_process	GO:0050891	multicellular organismal water homeostasis; IDA:UniProtKB.
# GO_process	GO:0050896	response to stimulus; IEA:UniProtKB-KW.
# GO_process	GO:0050909	sensory perception of taste; IEA:UniProtKB-KW.
# GO_process	GO:0055078	sodium ion homeostasis; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0005929	cilium
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P37088	HS
# HGNC	HGNC:10599	SCNN1A
# INDUCTION	By aldosterone. {ECO:0000269|PubMed	11266509}. 
# INTERACTION	SCNNA_HUMAN	P51170 SCNN1G; NbExp=3; IntAct=EBI-7845444, EBI-2547354; 
# IntAct	P37088	3
# InterPro	IPR001873	Na+channel_ASC
# InterPro	IPR004724	ENaC
# InterPro	IPR020903	Na+channel_ASC_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00243	[Endocrine disease; Urinary system disease] Pseudohypoaldosteronism type II (Gordon's syndrome)
# KEGG_Disease	H00892	[Respiratory disease] Bronchiectasis with or without elevated sweat chloride
# KEGG_Pathway	ko04742	Taste transduction
# KEGG_Pathway	ko04960	Aldosterone-regulated sodium reabsorption
# MIM	264350	phenotype
# MIM	600228	gene
# MIM	613021	phenotype
# Organism	SCNNA_HUMAN	Homo sapiens (Human)
# Orphanet	171876	Generalized pseudohypoaldosteronism type 1
# Orphanet	60033	Idiopathic bronchiectasis
# PANTHER	PTHR11690	PTHR11690
# PDB	2M3O	NMR; -; P=638-648
# PIR	A49585	A49585
# PRINTS	PR01078	AMINACHANNEL
# PROSITE	PS01206	ASC
# PTM	SCNNA_HUMAN	ENaC cleavage by furin, and subsequently by prostasin (PRSS8), leads to a stepwise increase in the open probability of the channel as a result of release of the alpha and gamma subunit inhibitory tracts, respectively. Interaction of ENaC subunit SCNN1B with BPIFA1 protects ENaC against proteolytic activation. {ECO 0000269|PubMed 18650438}. 
# PTM	SCNNA_HUMAN	N-glycosylated. {ECO 0000250|UniProtKB P37089}. 
# PTM	SCNNA_HUMAN	Ubiquitinated; this targets individual subunits for endocytosis and proteasome-mediated degradation. {ECO 0000250|UniProtKB P37089}. 
# Pfam	PF00858	ASC
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	SCNNA_HUMAN	Amiloride-sensitive sodium channel subunit alpha
# RefSeq	NP_001029	NM_001038.5. [P37088-1]
# RefSeq	NP_001153047	NM_001159575.1. [P37088-6]
# RefSeq	NP_001153048	NM_001159576.1. [P37088-2]
# SEQUENCE CAUTION	Sequence=AAH06526.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	SCNNA_HUMAN	Apical cell membrane {ECO 0000269|PubMed 22207244}; Multi-pass membrane protein {ECO 0000250|UniProtKB P37089}. Cell projection, cilium {ECO 0000269|PubMed 22207244}. Note=In the oviduct and bronchus, located on cilia in multi-ciliated cells. In endometrial non- ciliated epithelial cells, restricted to apical surfaces. {ECO 0000269|PubMed 22207244, ECO 0000269|PubMed 24124190}. 
# SUBUNIT	SCNNA_HUMAN	Heterotrimer containing an alpha/SCNN1A, a beta/SCNN1B and a gamma/SCNN1G subunit. An additional delta/SCNN1D subunit exists only in some organisms and can replace the alpha/SCNN1A subunit to form an alternative channel with specific properties (By similarity). Interacts with NEDD4 (via WW domains) (PubMed 11244092, PubMed 11696533, PubMed 12167593, PubMed 23665454). Interacts with NEDD4L (via WW domains) (PubMed 11244092, PubMed 11696533). Interacts with WWP1 (via WW domains) (PubMed 9169421). Interacts with WWP2 (via WW domains) (PubMed 12167593, PubMed 9169421). Interacts with the full length immature form of PCSK9 (pro-PCSK9) (PubMed 22493497). {ECO 0000250|UniProtKB Q61180, ECO 0000269|PubMed 11244092, ECO 0000269|PubMed 11696533, ECO 0000269|PubMed 12167593, ECO 0000269|PubMed 22493497, ECO 0000269|PubMed 23665454, ECO 0000269|PubMed 9169421}. 
# TCDB	1.A.6.1	the epithelial na(+) channel (enac) family
# TIGRFAMs	TIGR00859	ENaC
# TISSUE SPECIFICITY	SCNNA_HUMAN	Expressed in the female reproductive tract, from the fimbrial end of the fallopian tube to the endometrium (at protein level). Expressed in kidney (at protein level). In the respiratory tract, expressed in the bronchial epithelium (at protein level). Highly expressed in lung. Detected at intermediate levels in pancreas and liver, and at low levels in heart and placenta. Isoform 1 and isoform 2 predominate in all tissues. Expression of isoform 3, isoform 4 and isoform 5 is very low or not detectable, except in lung and heart. {ECO 0000269|PubMed 22207244, ECO 0000269|PubMed 9575806}. 
# UCSC	uc001qnw	human. [P37088-1]
# eggNOG	ENOG410ZNFK	LUCA
# eggNOG	KOG4294	Eukaryota
BLAST	swissprot:SCNNA_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SCNNA_HUMAN
BioCyc	ZFISH:ENSG00000111319-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000111319-MONOMER
COXPRESdb	6337	http://coxpresdb.jp/data/gene/6337.shtml
CleanEx	HS_SCNN1A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SCNN1A
DOI	10.1002/humu.21011	http://dx.doi.org/10.1002/humu.21011
DOI	10.1007/s00418-011-0904-1	http://dx.doi.org/10.1007/s00418-011-0904-1
DOI	10.1007/s004390050743	http://dx.doi.org/10.1007/s004390050743
DOI	10.1016/S0022-3476(99)70094-6	http://dx.doi.org/10.1016/S0022-3476(99)70094-6
DOI	10.1016/j.bbapap.2013.04.031	http://dx.doi.org/10.1016/j.bbapap.2013.04.031
DOI	10.1016/j.gene.2015.12.061	http://dx.doi.org/10.1016/j.gene.2015.12.061
DOI	10.1016/j.jcf.2007.07.012	http://dx.doi.org/10.1016/j.jcf.2007.07.012
DOI	10.1016/j.jsbmb.2008.06.013	http://dx.doi.org/10.1016/j.jsbmb.2008.06.013
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.91.1.247	http://dx.doi.org/10.1073/pnas.91.1.247
DOI	10.1074/jbc.272.23.14611	http://dx.doi.org/10.1074/jbc.272.23.14611
DOI	10.1074/jbc.C000906200	http://dx.doi.org/10.1074/jbc.C000906200
DOI	10.1074/jbc.C100623200	http://dx.doi.org/10.1074/jbc.C100623200
DOI	10.1074/jbc.M112.363382	http://dx.doi.org/10.1074/jbc.M112.363382
DOI	10.1074/jbc.M803931200	http://dx.doi.org/10.1074/jbc.M803931200
DOI	10.1093/hmg/ddi374	http://dx.doi.org/10.1093/hmg/ddi374
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1365-2265.2005.02255.x	http://dx.doi.org/10.1111/j.1365-2265.2005.02255.x
DOI	10.1152/ajplung.00103.2013	http://dx.doi.org/10.1152/ajplung.00103.2013
DOI	10.1152/ajprenal.00080.2002	http://dx.doi.org/10.1152/ajprenal.00080.2002
DOI	10.1161/01.HYP.34.4.631	http://dx.doi.org/10.1161/01.HYP.34.4.631
DOI	10.1203/00006450-199908000-00014	http://dx.doi.org/10.1203/00006450-199908000-00014
DOI	10.1210/jc.84.7.2434	http://dx.doi.org/10.1210/jc.84.7.2434
DOI	10.1210/jcem-73-5-936	http://dx.doi.org/10.1210/jcem-73-5-936
DOI	10.1210/jcem.87.7.8674	http://dx.doi.org/10.1210/jcem.87.7.8674
DOI	10.1210/me.15.4.575	http://dx.doi.org/10.1210/me.15.4.575
DOI	10.1373/clinchem.2004.046276	http://dx.doi.org/10.1373/clinchem.2004.046276
DrugBank	DB00384	http://www.drugbank.ca/drugs/DB00384
DrugBank	DB00594	http://www.drugbank.ca/drugs/DB00594
EMBL	AC005840	http://www.ebi.ac.uk/ena/data/view/AC005840
EMBL	AC006057	http://www.ebi.ac.uk/ena/data/view/AC006057
EMBL	AF060910	http://www.ebi.ac.uk/ena/data/view/AF060910
EMBL	AF060911	http://www.ebi.ac.uk/ena/data/view/AF060911
EMBL	AF060912	http://www.ebi.ac.uk/ena/data/view/AF060912
EMBL	AF060913	http://www.ebi.ac.uk/ena/data/view/AF060913
EMBL	AK304379	http://www.ebi.ac.uk/ena/data/view/AK304379
EMBL	BC006526	http://www.ebi.ac.uk/ena/data/view/BC006526
EMBL	BC062613	http://www.ebi.ac.uk/ena/data/view/BC062613
EMBL	CH471116	http://www.ebi.ac.uk/ena/data/view/CH471116
EMBL	DQ402522	http://www.ebi.ac.uk/ena/data/view/DQ402522
EMBL	FJ515830	http://www.ebi.ac.uk/ena/data/view/FJ515830
EMBL	L29007	http://www.ebi.ac.uk/ena/data/view/L29007
EMBL	U81961	http://www.ebi.ac.uk/ena/data/view/U81961
EMBL	U81961	http://www.ebi.ac.uk/ena/data/view/U81961
EMBL	X76180	http://www.ebi.ac.uk/ena/data/view/X76180
EMBL	Z92978	http://www.ebi.ac.uk/ena/data/view/Z92978
EMBL	Z92979	http://www.ebi.ac.uk/ena/data/view/Z92979
EMBL	Z92980	http://www.ebi.ac.uk/ena/data/view/Z92980
EMBL	Z92981	http://www.ebi.ac.uk/ena/data/view/Z92981
Ensembl	ENST00000228916	http://www.ensembl.org/id/ENST00000228916
Ensembl	ENST00000360168	http://www.ensembl.org/id/ENST00000360168
Ensembl	ENST00000543768	http://www.ensembl.org/id/ENST00000543768
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0031514	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031514
GO_component	GO:0034706	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034706
GO_component	GO:0060170	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060170
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0015280	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015280
GO_function	GO:0050699	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050699
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0035725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035725
GO_process	GO:0050891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050891
GO_process	GO:0050896	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050896
GO_process	GO:0050909	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050909
GO_process	GO:0055078	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055078
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0005929	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005929
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SCNN1A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SCNN1A
GeneID	6337	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6337
GeneTree	ENSGT00760000119120	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119120
HGNC	HGNC:10599	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10599
HOGENOM	HOG000236286	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236286&db=HOGENOM6
HOVERGEN	HBG058435	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG058435&db=HOVERGEN
HPA	HPA012743	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA012743
HPA	HPA012939	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA012939
InParanoid	P37088	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37088
IntAct	P37088	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37088*
InterPro	IPR001873	http://www.ebi.ac.uk/interpro/entry/IPR001873
InterPro	IPR004724	http://www.ebi.ac.uk/interpro/entry/IPR004724
InterPro	IPR020903	http://www.ebi.ac.uk/interpro/entry/IPR020903
Jabion	6337	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6337
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00243	http://www.genome.jp/dbget-bin/www_bget?H00243
KEGG_Disease	H00892	http://www.genome.jp/dbget-bin/www_bget?H00892
KEGG_Gene	hsa:6337	http://www.genome.jp/dbget-bin/www_bget?hsa:6337
KEGG_Orthology	KO:K04824	http://www.genome.jp/dbget-bin/www_bget?KO:K04824
KEGG_Pathway	ko04742	http://www.genome.jp/kegg-bin/show_pathway?ko04742
KEGG_Pathway	ko04960	http://www.genome.jp/kegg-bin/show_pathway?ko04960
MIM	264350	http://www.ncbi.nlm.nih.gov/omim/264350
MIM	600228	http://www.ncbi.nlm.nih.gov/omim/600228
MIM	613021	http://www.ncbi.nlm.nih.gov/omim/613021
MINT	MINT-198663	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-198663
OMA	APPPNSH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=APPPNSH
Orphanet	171876	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=171876
Orphanet	60033	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=60033
OrthoDB	EOG091G0KW6	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0KW6
PANTHER	PTHR11690	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11690
PDB	2M3O	http://www.ebi.ac.uk/pdbe-srv/view/entry/2M3O
PDBsum	2M3O	http://www.ebi.ac.uk/pdbsum/2M3O
PRINTS	PR01078	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01078
PROSITE	PS01206	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01206
PSORT	swissprot:SCNNA_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SCNNA_HUMAN
PSORT-B	swissprot:SCNNA_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SCNNA_HUMAN
PSORT2	swissprot:SCNNA_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SCNNA_HUMAN
Pfam	PF00858	http://pfam.xfam.org/family/PF00858
PharmGKB	PA305	http://www.pharmgkb.org/do/serve?objId=PA305&objCls=Gene
Phobius	swissprot:SCNNA_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SCNNA_HUMAN
PhylomeDB	P37088	http://phylomedb.org/?seqid=P37088
ProteinModelPortal	P37088	http://www.proteinmodelportal.org/query/uniprot/P37088
PubMed	10404817	http://www.ncbi.nlm.nih.gov/pubmed/10404817
PubMed	10447117	http://www.ncbi.nlm.nih.gov/pubmed/10447117
PubMed	10523338	http://www.ncbi.nlm.nih.gov/pubmed/10523338
PubMed	10586178	http://www.ncbi.nlm.nih.gov/pubmed/10586178
PubMed	11244092	http://www.ncbi.nlm.nih.gov/pubmed/11244092
PubMed	11266509	http://www.ncbi.nlm.nih.gov/pubmed/11266509
PubMed	11696533	http://www.ncbi.nlm.nih.gov/pubmed/11696533
PubMed	12107247	http://www.ncbi.nlm.nih.gov/pubmed/12107247
PubMed	12167593	http://www.ncbi.nlm.nih.gov/pubmed/12167593
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15734793	http://www.ncbi.nlm.nih.gov/pubmed/15734793
PubMed	15853823	http://www.ncbi.nlm.nih.gov/pubmed/15853823
PubMed	16207733	http://www.ncbi.nlm.nih.gov/pubmed/16207733
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	17766193	http://www.ncbi.nlm.nih.gov/pubmed/17766193
PubMed	18634878	http://www.ncbi.nlm.nih.gov/pubmed/18634878
PubMed	18650438	http://www.ncbi.nlm.nih.gov/pubmed/18650438
PubMed	1939532	http://www.ncbi.nlm.nih.gov/pubmed/1939532
PubMed	19462466	http://www.ncbi.nlm.nih.gov/pubmed/19462466
PubMed	22207244	http://www.ncbi.nlm.nih.gov/pubmed/22207244
PubMed	22493497	http://www.ncbi.nlm.nih.gov/pubmed/22493497
PubMed	23547933	http://www.ncbi.nlm.nih.gov/pubmed/23547933
PubMed	23665454	http://www.ncbi.nlm.nih.gov/pubmed/23665454
PubMed	24124190	http://www.ncbi.nlm.nih.gov/pubmed/24124190
PubMed	26772908	http://www.ncbi.nlm.nih.gov/pubmed/26772908
PubMed	8023962	http://www.ncbi.nlm.nih.gov/pubmed/8023962
PubMed	8278374	http://www.ncbi.nlm.nih.gov/pubmed/8278374
PubMed	9169421	http://www.ncbi.nlm.nih.gov/pubmed/9169421
PubMed	9575806	http://www.ncbi.nlm.nih.gov/pubmed/9575806
PubMed	9612219	http://www.ncbi.nlm.nih.gov/pubmed/9612219
PubMed	9654208	http://www.ncbi.nlm.nih.gov/pubmed/9654208
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_001029	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001029
RefSeq	NP_001153047	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001153047
RefSeq	NP_001153048	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001153048
SMR	P37088	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37088
STRING	9606.ENSP00000353292	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000353292&targetmode=cogs
TCDB	1.A.6.1	http://www.tcdb.org/search/result.php?tc=1.A.6.1
TIGRFAMs	TIGR00859	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00859
UCSC	uc001qnw	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001qnw&org=rat
UniGene	Hs.591047	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.591047
UniProtKB	SCNNA_HUMAN	http://www.uniprot.org/uniprot/SCNNA_HUMAN
UniProtKB-AC	P37088	http://www.uniprot.org/uniprot/P37088
charge	swissprot:SCNNA_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SCNNA_HUMAN
eggNOG	ENOG410ZNFK	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZNFK
eggNOG	KOG4294	http://eggnogapi.embl.de/nog_data/html/tree/KOG4294
epestfind	swissprot:SCNNA_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SCNNA_HUMAN
garnier	swissprot:SCNNA_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SCNNA_HUMAN
helixturnhelix	swissprot:SCNNA_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SCNNA_HUMAN
hmoment	swissprot:SCNNA_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SCNNA_HUMAN
iep	swissprot:SCNNA_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SCNNA_HUMAN
inforesidue	swissprot:SCNNA_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SCNNA_HUMAN
neXtProt	NX_P37088	http://www.nextprot.org/db/entry/NX_P37088
octanol	swissprot:SCNNA_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SCNNA_HUMAN
pepcoil	swissprot:SCNNA_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SCNNA_HUMAN
pepdigest	swissprot:SCNNA_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SCNNA_HUMAN
pepinfo	swissprot:SCNNA_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SCNNA_HUMAN
pepnet	swissprot:SCNNA_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SCNNA_HUMAN
pepstats	swissprot:SCNNA_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SCNNA_HUMAN
pepwheel	swissprot:SCNNA_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SCNNA_HUMAN
pepwindow	swissprot:SCNNA_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SCNNA_HUMAN
sigcleave	swissprot:SCNNA_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SCNNA_HUMAN
## Database	ID	URL or Descriptions
# AltName	GBRP_HUMAN	GABA(A) receptor subunit pi
# ChiTaRS	GABRP	human
# DrugBank	DB00186	Lorazepam
# DrugBank	DB00189	Ethchlorvynol
# DrugBank	DB00228	Enflurane
# DrugBank	DB00231	Temazepam
# DrugBank	DB00237	Butabarbital
# DrugBank	DB00241	Butalbital
# DrugBank	DB00273	Topiramate
# DrugBank	DB00292	Etomidate
# DrugBank	DB00306	Talbutal
# DrugBank	DB00312	Pentobarbital
# DrugBank	DB00334	Olanzapine
# DrugBank	DB00349	Clobazam
# DrugBank	DB00371	Meprobamate
# DrugBank	DB00402	Eszopiclone
# DrugBank	DB00404	Alprazolam
# DrugBank	DB00475	Chlordiazepoxide
# DrugBank	DB00543	Amoxapine
# DrugBank	DB00546	Adinazolam
# DrugBank	DB00628	Clorazepate
# DrugBank	DB00659	Acamprosate
# DrugBank	DB00683	Midazolam
# DrugBank	DB00690	Flurazepam
# DrugBank	DB00753	Isoflurane
# DrugBank	DB00794	Primidone
# DrugBank	DB00801	Halazepam
# DrugBank	DB00818	Propofol
# DrugBank	DB00829	Diazepam
# DrugBank	DB00842	Oxazepam
# DrugBank	DB00897	Triazolam
# DrugBank	DB00898	Ethanol
# DrugBank	DB01028	Methoxyflurane
# DrugBank	DB01049	Ergoloid mesylate
# DrugBank	DB01068	Clonazepam
# DrugBank	DB01107	Methyprylon
# DrugBank	DB01159	Halothane
# DrugBank	DB01189	Desflurane
# DrugBank	DB01205	Flumazenil
# DrugBank	DB01215	Estazolam
# DrugBank	DB01236	Sevoflurane
# DrugBank	DB01437	Glutethimide
# DrugBank	DB01558	Bromazepam
# DrugBank	DB01559	Clotiazepam
# DrugBank	DB01567	Fludiazepam
# DrugBank	DB01588	Prazepam
# DrugBank	DB01589	Quazepam
# DrugBank	DB01594	Cinolazepam
# DrugBank	DB01595	Nitrazepam
# Ensembl	ENST00000265294	ENSP00000265294; ENSG00000094755
# Ensembl	ENST00000518525	ENSP00000430100; ENSG00000094755
# ExpressionAtlas	O00591	baseline and differential
# FUNCTION	GBRP_HUMAN	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone. 
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0004890	GABA-A receptor activity; TAS:ProtInc.
# GO_function	GO:0008068	extracellular-glutamate-gated chloride channel activity; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# Gene3D	2.70.170.10	-; 1.
# Genevisible	O00591	HS
# HGNC	HGNC:4089	GABRP
# InterPro	IPR006028	GABAA/Glycine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR008100	GABAAp_rcpt
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04727	GABAergic synapse
# KEGG_Pathway	ko05032	Morphine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# MIM	602729	gene
# Organism	GBRP_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR18945	PTHR18945
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00253	GABAARECEPTR
# PRINTS	PR01724	GABAARPI
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 5
# RecName	GBRP_HUMAN	Gamma-aminobutyric acid receptor subunit pi
# RefSeq	NP_001278914	NM_001291985.1
# RefSeq	NP_055026	NM_014211.2
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRP sub-subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	GBRP_HUMAN	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and epsilon. A sixth class of subunit	 Rho form homomeric GABA receptors that do not appear to coexist with GABA(A) receptor subunits but with GABA(C) receptor subunits. Subunit Pi can also bind this complex. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TIGRFAMs	TIGR00860	LIC
# TISSUE SPECIFICITY	GBRP_HUMAN	Most abundant in the uterus, also expressed in lung, thymus and prostate. 
# UCSC	uc003mau	human
# eggNOG	ENOG410XPWH	LUCA
# eggNOG	KOG3643	Eukaryota
BLAST	swissprot:GBRP_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GBRP_HUMAN
BioCyc	ZFISH:ENSG00000094755-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000094755-MONOMER
COXPRESdb	2568	http://coxpresdb.jp/data/gene/2568.shtml
CleanEx	HS_GABRP	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GABRP
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.272.24.15346	http://dx.doi.org/10.1074/jbc.272.24.15346
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DrugBank	DB00186	http://www.drugbank.ca/drugs/DB00186
DrugBank	DB00189	http://www.drugbank.ca/drugs/DB00189
DrugBank	DB00228	http://www.drugbank.ca/drugs/DB00228
DrugBank	DB00231	http://www.drugbank.ca/drugs/DB00231
DrugBank	DB00237	http://www.drugbank.ca/drugs/DB00237
DrugBank	DB00241	http://www.drugbank.ca/drugs/DB00241
DrugBank	DB00273	http://www.drugbank.ca/drugs/DB00273
DrugBank	DB00292	http://www.drugbank.ca/drugs/DB00292
DrugBank	DB00306	http://www.drugbank.ca/drugs/DB00306
DrugBank	DB00312	http://www.drugbank.ca/drugs/DB00312
DrugBank	DB00334	http://www.drugbank.ca/drugs/DB00334
DrugBank	DB00349	http://www.drugbank.ca/drugs/DB00349
DrugBank	DB00371	http://www.drugbank.ca/drugs/DB00371
DrugBank	DB00402	http://www.drugbank.ca/drugs/DB00402
DrugBank	DB00404	http://www.drugbank.ca/drugs/DB00404
DrugBank	DB00475	http://www.drugbank.ca/drugs/DB00475
DrugBank	DB00543	http://www.drugbank.ca/drugs/DB00543
DrugBank	DB00546	http://www.drugbank.ca/drugs/DB00546
DrugBank	DB00628	http://www.drugbank.ca/drugs/DB00628
DrugBank	DB00659	http://www.drugbank.ca/drugs/DB00659
DrugBank	DB00683	http://www.drugbank.ca/drugs/DB00683
DrugBank	DB00690	http://www.drugbank.ca/drugs/DB00690
DrugBank	DB00753	http://www.drugbank.ca/drugs/DB00753
DrugBank	DB00794	http://www.drugbank.ca/drugs/DB00794
DrugBank	DB00801	http://www.drugbank.ca/drugs/DB00801
DrugBank	DB00818	http://www.drugbank.ca/drugs/DB00818
DrugBank	DB00829	http://www.drugbank.ca/drugs/DB00829
DrugBank	DB00842	http://www.drugbank.ca/drugs/DB00842
DrugBank	DB00897	http://www.drugbank.ca/drugs/DB00897
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01028	http://www.drugbank.ca/drugs/DB01028
DrugBank	DB01049	http://www.drugbank.ca/drugs/DB01049
DrugBank	DB01068	http://www.drugbank.ca/drugs/DB01068
DrugBank	DB01107	http://www.drugbank.ca/drugs/DB01107
DrugBank	DB01159	http://www.drugbank.ca/drugs/DB01159
DrugBank	DB01189	http://www.drugbank.ca/drugs/DB01189
DrugBank	DB01205	http://www.drugbank.ca/drugs/DB01205
DrugBank	DB01215	http://www.drugbank.ca/drugs/DB01215
DrugBank	DB01236	http://www.drugbank.ca/drugs/DB01236
DrugBank	DB01437	http://www.drugbank.ca/drugs/DB01437
DrugBank	DB01558	http://www.drugbank.ca/drugs/DB01558
DrugBank	DB01559	http://www.drugbank.ca/drugs/DB01559
DrugBank	DB01567	http://www.drugbank.ca/drugs/DB01567
DrugBank	DB01588	http://www.drugbank.ca/drugs/DB01588
DrugBank	DB01589	http://www.drugbank.ca/drugs/DB01589
DrugBank	DB01594	http://www.drugbank.ca/drugs/DB01594
DrugBank	DB01595	http://www.drugbank.ca/drugs/DB01595
EMBL	AF009694	http://www.ebi.ac.uk/ena/data/view/AF009694
EMBL	AF009695	http://www.ebi.ac.uk/ena/data/view/AF009695
EMBL	AF009696	http://www.ebi.ac.uk/ena/data/view/AF009696
EMBL	AF009697	http://www.ebi.ac.uk/ena/data/view/AF009697
EMBL	AF009698	http://www.ebi.ac.uk/ena/data/view/AF009698
EMBL	AF009699	http://www.ebi.ac.uk/ena/data/view/AF009699
EMBL	AF009700	http://www.ebi.ac.uk/ena/data/view/AF009700
EMBL	AF009701	http://www.ebi.ac.uk/ena/data/view/AF009701
EMBL	AF009702	http://www.ebi.ac.uk/ena/data/view/AF009702
EMBL	AK292901	http://www.ebi.ac.uk/ena/data/view/AK292901
EMBL	BC074810	http://www.ebi.ac.uk/ena/data/view/BC074810
EMBL	BC074865	http://www.ebi.ac.uk/ena/data/view/BC074865
EMBL	BC109105	http://www.ebi.ac.uk/ena/data/view/BC109105
EMBL	BC109106	http://www.ebi.ac.uk/ena/data/view/BC109106
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	U95367	http://www.ebi.ac.uk/ena/data/view/U95367
Ensembl	ENST00000265294	http://www.ensembl.org/id/ENST00000265294
Ensembl	ENST00000518525	http://www.ensembl.org/id/ENST00000518525
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0004890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004890
GO_function	GO:0008068	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008068
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	GABRP	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GABRP
GeneID	2568	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2568
GeneTree	ENSGT00760000118821	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118821
HGNC	HGNC:4089	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4089
HOGENOM	HOG000231335	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231335&db=HOGENOM6
HOVERGEN	HBG051707	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051707&db=HOVERGEN
HPA	CAB014883	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB014883
InParanoid	O00591	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O00591
InterPro	IPR006028	http://www.ebi.ac.uk/interpro/entry/IPR006028
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR008100	http://www.ebi.ac.uk/interpro/entry/IPR008100
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
Jabion	2568	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2568
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:2568	http://www.genome.jp/dbget-bin/www_bget?hsa:2568
KEGG_Orthology	KO:K05189	http://www.genome.jp/dbget-bin/www_bget?KO:K05189
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
KEGG_Pathway	ko05032	http://www.genome.jp/kegg-bin/show_pathway?ko05032
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
MIM	602729	http://www.ncbi.nlm.nih.gov/omim/602729
OMA	NDVEFSW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NDVEFSW
OrthoDB	EOG091G0805	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0805
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00253	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00253
PRINTS	PR01724	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01724
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:GBRP_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GBRP_HUMAN
PSORT-B	swissprot:GBRP_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GBRP_HUMAN
PSORT2	swissprot:GBRP_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GBRP_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA28503	http://www.pharmgkb.org/do/serve?objId=PA28503&objCls=Gene
Phobius	swissprot:GBRP_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GBRP_HUMAN
PhylomeDB	O00591	http://phylomedb.org/?seqid=O00591
ProteinModelPortal	O00591	http://www.proteinmodelportal.org/query/uniprot/O00591
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	9182563	http://www.ncbi.nlm.nih.gov/pubmed/9182563
RefSeq	NP_001278914	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001278914
RefSeq	NP_055026	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055026
STRING	9606.ENSP00000265294	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000265294&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc003mau	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003mau&org=rat
UniGene	Hs.26225	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.26225
UniProtKB	GBRP_HUMAN	http://www.uniprot.org/uniprot/GBRP_HUMAN
UniProtKB-AC	O00591	http://www.uniprot.org/uniprot/O00591
charge	swissprot:GBRP_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GBRP_HUMAN
eggNOG	ENOG410XPWH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPWH
eggNOG	KOG3643	http://eggnogapi.embl.de/nog_data/html/tree/KOG3643
epestfind	swissprot:GBRP_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GBRP_HUMAN
garnier	swissprot:GBRP_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GBRP_HUMAN
helixturnhelix	swissprot:GBRP_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GBRP_HUMAN
hmoment	swissprot:GBRP_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GBRP_HUMAN
iep	swissprot:GBRP_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GBRP_HUMAN
inforesidue	swissprot:GBRP_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GBRP_HUMAN
neXtProt	NX_O00591	http://www.nextprot.org/db/entry/NX_O00591
octanol	swissprot:GBRP_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GBRP_HUMAN
pepcoil	swissprot:GBRP_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GBRP_HUMAN
pepdigest	swissprot:GBRP_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GBRP_HUMAN
pepinfo	swissprot:GBRP_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GBRP_HUMAN
pepnet	swissprot:GBRP_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GBRP_HUMAN
pepstats	swissprot:GBRP_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GBRP_HUMAN
pepwheel	swissprot:GBRP_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GBRP_HUMAN
pepwindow	swissprot:GBRP_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GBRP_HUMAN
sigcleave	swissprot:GBRP_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GBRP_HUMAN
## Database	ID	URL or Descriptions
# AltName	CXG1_HUMAN	Connexin-45
# AltName	CXG1_HUMAN	Gap junction alpha-7 protein
# BioGrid	115363	15
# ChiTaRS	GJC1	human
# Ensembl	ENST00000330514	ENSP00000333193; ENSG00000182963
# Ensembl	ENST00000426548	ENSP00000411528; ENSG00000182963
# Ensembl	ENST00000590758	ENSP00000466339; ENSG00000182963
# Ensembl	ENST00000592524	ENSP00000467201; ENSG00000182963
# ExpressionAtlas	P36383	baseline and differential
# FUNCTION	CXG1_HUMAN	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. 
# GO_component	GO:0005789	endoplasmic reticulum membrane; TAS:Reactome.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005921	gap junction; TAS:ProtInc.
# GO_component	GO:0005922	connexin complex; IEA:Ensembl.
# GO_component	GO:0014704	intercalated disc; TAS:BHF-UCL.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005216	ion channel activity; IEA:Ensembl.
# GO_function	GO:0005243	gap junction channel activity; IEA:Ensembl.
# GO_process	GO:0001570	vasculogenesis; IEA:Ensembl.
# GO_process	GO:0006810	transport; NAS:ProtInc.
# GO_process	GO:0006936	muscle contraction; TAS:ProtInc.
# GO_process	GO:0007043	cell-cell junction assembly; TAS:ProtInc.
# GO_process	GO:0007268	chemical synaptic transmission; IEA:Ensembl.
# GO_process	GO:0007601	visual perception; IEA:Ensembl.
# GO_process	GO:0016264	gap junction assembly; TAS:Reactome.
# GO_process	GO:0048468	cell development; IEA:Ensembl.
# GO_process	GO:0048738	cardiac muscle tissue development; IEA:Ensembl.
# GO_process	GO:0086014	atrial cardiac muscle cell action potential; TAS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0022607	cellular component assembly
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0034330	cell junction organization
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# Genevisible	P36383	HS
# HGNC	HGNC:4280	GJC1
# InterPro	IPR000500	Connexin
# InterPro	IPR002265	Connexin45
# InterPro	IPR013092	Connexin_N
# InterPro	IPR017990	Connexin_CS
# InterPro	IPR019570	Connexin_CCC
# MIM	608655	gene
# Organism	CXG1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11984	PTHR11984; 2
# PDB	3SHW	X-ray; 2.90 A; B=387-396
# PIR	I38430	I38430
# PRINTS	PR00206	CONNEXIN
# PRINTS	PR01136	CONNEXINA6
# PROSITE	PS00407	CONNEXINS_1
# PROSITE	PS00408	CONNEXINS_2
# Pfam	PF00029	Connexin
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-112303	Electric Transmission Across Gap Junctions
# Reactome	R-HSA-190861	Gap junction assembly
# RecName	CXG1_HUMAN	Gap junction gamma-1 protein
# RefSeq	NP_001073852	NM_001080383.1
# RefSeq	NP_005488	NM_005497.3
# RefSeq	XP_005256977	XM_005256920.1
# RefSeq	XP_005256978	XM_005256921.1
# SIMILARITY	Belongs to the connexin family. Gamma-type subfamily. {ECO	0000305}.
# SMART	SM00037	CNX
# SMART	SM01089	Connexin_CCC
# SUBCELLULAR LOCATION	CXG1_HUMAN	Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. 
# SUBUNIT	A connexon is composed of a hexamer of connexins. Interacts with CNST (By similarity). {ECO	0000250}. 
# TCDB	1.A.24.2	the gap junction-forming connexin (connexin) family
# UCSC	uc002ihj	human
# eggNOG	ENOG410IFK3	Eukaryota
# eggNOG	ENOG410Z7PN	LUCA
BLAST	swissprot:CXG1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CXG1_HUMAN
BioCyc	ZFISH:G66-33196-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33196-MONOMER
COXPRESdb	10052	http://coxpresdb.jp/data/gene/10052.shtml
CleanEx	HS_GJC1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GJC1
DOI	10.1006/jmcc.1994.1103	http://dx.doi.org/10.1006/jmcc.1994.1103
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC005180	http://www.ebi.ac.uk/ena/data/view/AC005180
EMBL	AK124339	http://www.ebi.ac.uk/ena/data/view/AK124339
EMBL	BC096213	http://www.ebi.ac.uk/ena/data/view/BC096213
EMBL	BC096214	http://www.ebi.ac.uk/ena/data/view/BC096214
EMBL	BC096215	http://www.ebi.ac.uk/ena/data/view/BC096215
EMBL	BC096216	http://www.ebi.ac.uk/ena/data/view/BC096216
EMBL	U03493	http://www.ebi.ac.uk/ena/data/view/U03493
Ensembl	ENST00000330514	http://www.ensembl.org/id/ENST00000330514
Ensembl	ENST00000426548	http://www.ensembl.org/id/ENST00000426548
Ensembl	ENST00000590758	http://www.ensembl.org/id/ENST00000590758
Ensembl	ENST00000592524	http://www.ensembl.org/id/ENST00000592524
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005921	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005921
GO_component	GO:0005922	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005922
GO_component	GO:0014704	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014704
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005216	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005216
GO_function	GO:0005243	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005243
GO_process	GO:0001570	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001570
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006936	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006936
GO_process	GO:0007043	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007043
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007601	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007601
GO_process	GO:0016264	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016264
GO_process	GO:0048468	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048468
GO_process	GO:0048738	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048738
GO_process	GO:0086014	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086014
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0022607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0034330	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034330
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	GJC1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GJC1
GeneID	10052	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10052
GeneTree	ENSGT00840000129674	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00840000129674
HGNC	HGNC:4280	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4280
HOGENOM	HOG000231126	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231126&db=HOGENOM6
HOVERGEN	HBG009576	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG009576&db=HOVERGEN
HPA	CAB073417	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB073417
InParanoid	P36383	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36383
IntAct	P36383	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36383*
InterPro	IPR000500	http://www.ebi.ac.uk/interpro/entry/IPR000500
InterPro	IPR002265	http://www.ebi.ac.uk/interpro/entry/IPR002265
InterPro	IPR013092	http://www.ebi.ac.uk/interpro/entry/IPR013092
InterPro	IPR017990	http://www.ebi.ac.uk/interpro/entry/IPR017990
InterPro	IPR019570	http://www.ebi.ac.uk/interpro/entry/IPR019570
Jabion	10052	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10052
KEGG_Gene	hsa:10052	http://www.genome.jp/dbget-bin/www_bget?hsa:10052
KEGG_Orthology	KO:K07616	http://www.genome.jp/dbget-bin/www_bget?KO:K07616
MIM	608655	http://www.ncbi.nlm.nih.gov/omim/608655
OMA	RWKQHRG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RWKQHRG
OrthoDB	EOG091G08B8	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08B8
PANTHER	PTHR11984	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11984
PDB	3SHW	http://www.ebi.ac.uk/pdbe-srv/view/entry/3SHW
PDBsum	3SHW	http://www.ebi.ac.uk/pdbsum/3SHW
PRINTS	PR00206	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00206
PRINTS	PR01136	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01136
PROSITE	PS00407	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00407
PROSITE	PS00408	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00408
PSORT	swissprot:CXG1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CXG1_HUMAN
PSORT-B	swissprot:CXG1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CXG1_HUMAN
PSORT2	swissprot:CXG1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CXG1_HUMAN
Pfam	PF00029	http://pfam.xfam.org/family/PF00029
PharmGKB	PA164741588	http://www.pharmgkb.org/do/serve?objId=PA164741588&objCls=Gene
Phobius	swissprot:CXG1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CXG1_HUMAN
PhylomeDB	P36383	http://phylomedb.org/?seqid=P36383
ProteinModelPortal	P36383	http://www.proteinmodelportal.org/query/uniprot/P36383
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	7966354	http://www.ncbi.nlm.nih.gov/pubmed/7966354
Reactome	R-HSA-112303	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112303
Reactome	R-HSA-190861	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-190861
RefSeq	NP_001073852	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001073852
RefSeq	NP_005488	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005488
RefSeq	XP_005256977	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005256977
RefSeq	XP_005256978	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005256978
SMART	SM00037	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00037
SMART	SM01089	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01089
SMR	P36383	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P36383
STRING	9606.ENSP00000333193	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000333193&targetmode=cogs
TCDB	1.A.24.2	http://www.tcdb.org/search/result.php?tc=1.A.24.2
UCSC	uc002ihj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ihj&org=rat
UniGene	Hs.712052	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.712052
UniGene	Hs.744748	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.744748
UniProtKB	CXG1_HUMAN	http://www.uniprot.org/uniprot/CXG1_HUMAN
UniProtKB-AC	P36383	http://www.uniprot.org/uniprot/P36383
charge	swissprot:CXG1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CXG1_HUMAN
eggNOG	ENOG410IFK3	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IFK3
eggNOG	ENOG410Z7PN	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z7PN
epestfind	swissprot:CXG1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CXG1_HUMAN
garnier	swissprot:CXG1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CXG1_HUMAN
helixturnhelix	swissprot:CXG1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CXG1_HUMAN
hmoment	swissprot:CXG1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CXG1_HUMAN
iep	swissprot:CXG1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CXG1_HUMAN
inforesidue	swissprot:CXG1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CXG1_HUMAN
neXtProt	NX_P36383	http://www.nextprot.org/db/entry/NX_P36383
octanol	swissprot:CXG1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CXG1_HUMAN
pepcoil	swissprot:CXG1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CXG1_HUMAN
pepdigest	swissprot:CXG1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CXG1_HUMAN
pepinfo	swissprot:CXG1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CXG1_HUMAN
pepnet	swissprot:CXG1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CXG1_HUMAN
pepstats	swissprot:CXG1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CXG1_HUMAN
pepwheel	swissprot:CXG1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CXG1_HUMAN
pepwindow	swissprot:CXG1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CXG1_HUMAN
sigcleave	swissprot:CXG1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CXG1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	5HT3D_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q70Z44-1; Sequence=Displayed; Name=2; IsoId=Q70Z44-2; Sequence=VSP_029798, VSP_029799, VSP_029801; Name=3; IsoId=Q70Z44-3; Sequence=VSP_029797, VSP_029800, VSP_029801; Name=4; IsoId=Q70Z44-4; Sequence=VSP_044828, VSP_044829, VSP_044830, VSP_029801; Note=No experimental confirmation available.; 
# AltName	5HT3D_HUMAN	Serotonin receptor 3D
# BioGrid	128355	3
# CCDS	CCDS3249	-. [Q70Z44-2]
# CCDS	CCDS46966	-. [Q70Z44-4]
# CCDS	CCDS54685	-. [Q70Z44-1]
# DrugBank	DB00898	Ethanol
# DrugBank	DB01049	Ergoloid mesylate
# Ensembl	ENST00000382489	ENSP00000371929; ENSG00000186090. [Q70Z44-1]
# Ensembl	ENST00000428798	ENSP00000405409; ENSG00000186090. [Q70Z44-4]
# Ensembl	ENST00000453435	ENSP00000389268; ENSG00000186090. [Q70Z44-3]
# ExpressionAtlas	Q70Z44	baseline and differential
# FUNCTION	5HT3D_HUMAN	This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0004993	G-protein coupled serotonin receptor activity; IDA:CACAO.
# GO_function	GO:0005232	serotonin-activated cation-selective channel activity; IBA:GO_Central.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.370	-; 1.
# Gene3D	2.70.170.10	-; 1.
# HGNC	HGNC:24004	HTR3D
# INTERACTION	5HT3D_HUMAN	P46098 HTR3A; NbExp=5; IntAct=EBI-9008717, EBI-9008743; 
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR027361	Acetylcholine_rcpt_TM
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04726	Serotonergic synapse
# MIM	610122	gene
# Organism	5HT3D_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR18945	PTHR18945
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-975298	Ligand-gated ion channel transport
# RecName	5HT3D_HUMAN	5-hydroxytryptamine receptor 3D
# RefSeq	NP_001138615	NM_001145143.1. [Q70Z44-4]
# RefSeq	NP_001157118	NM_001163646.1. [Q70Z44-1]
# RefSeq	NP_872343	NM_182537.2
# RefSeq	XP_016861343	XM_017005854.1. [Q70Z44-3]
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3D sub-subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	5HT3D_HUMAN	Cell membrane {ECO 0000269|PubMed 17392525}; Multi-pass membrane protein {ECO 0000269|PubMed 17392525}. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. 
# SUBUNIT	Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex. {ECO:0000269|PubMed	17392525}. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TCDB	1.A.9.2	the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family
# TISSUE SPECIFICITY	Expressed in liver, as well as fetal and adult colon and kidney. {ECO:0000269|PubMed	12801637}. 
# UCSC	uc010hxp	human. [Q70Z44-1]
# eggNOG	ENOG410XQGR	LUCA
# eggNOG	KOG3645	Eukaryota
BLAST	swissprot:5HT3D_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:5HT3D_HUMAN
BioCyc	ZFISH:G66-32385-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32385-MONOMER
COXPRESdb	200909	http://coxpresdb.jp/data/gene/200909.shtml
CleanEx	HS_HTR3D	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_HTR3D
DOI	10.1016/S0378-1119(03)00503-1	http://dx.doi.org/10.1016/S0378-1119(03)00503-1
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1124/mol.106.032144	http://dx.doi.org/10.1124/mol.106.032144
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01049	http://www.drugbank.ca/drugs/DB01049
EMBL	AC068644	http://www.ebi.ac.uk/ena/data/view/AC068644
EMBL	AC131235	http://www.ebi.ac.uk/ena/data/view/AC131235
EMBL	AJ437318	http://www.ebi.ac.uk/ena/data/view/AJ437318
EMBL	AY159812	http://www.ebi.ac.uk/ena/data/view/AY159812
EMBL	BC101090	http://www.ebi.ac.uk/ena/data/view/BC101090
EMBL	BC101091	http://www.ebi.ac.uk/ena/data/view/BC101091
Ensembl	ENST00000382489	http://www.ensembl.org/id/ENST00000382489
Ensembl	ENST00000428798	http://www.ensembl.org/id/ENST00000428798
Ensembl	ENST00000453435	http://www.ensembl.org/id/ENST00000453435
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0004993	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004993
GO_function	GO:0005232	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005232
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.370	http://www.cathdb.info/version/latest/superfamily/1.20.120.370
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	HTR3D	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=HTR3D
GeneID	200909	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=200909
GeneTree	ENSGT00790000122957	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00790000122957
HGNC	HGNC:24004	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:24004
HOGENOM	HOG000241519	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000241519&db=HOGENOM6
HOVERGEN	HBG106638	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG106638&db=HOVERGEN
InParanoid	Q70Z44	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q70Z44
IntAct	Q70Z44	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q70Z44*
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR027361	http://www.ebi.ac.uk/interpro/entry/IPR027361
Jabion	200909	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=200909
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:200909	http://www.genome.jp/dbget-bin/www_bget?hsa:200909
KEGG_Orthology	KO:K04819	http://www.genome.jp/dbget-bin/www_bget?KO:K04819
KEGG_Pathway	ko04726	http://www.genome.jp/kegg-bin/show_pathway?ko04726
MIM	610122	http://www.ncbi.nlm.nih.gov/omim/610122
OMA	FRAREWV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FRAREWV
OrthoDB	EOG091G0DE5	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0DE5
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PSORT	swissprot:5HT3D_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:5HT3D_HUMAN
PSORT-B	swissprot:5HT3D_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:5HT3D_HUMAN
PSORT2	swissprot:5HT3D_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:5HT3D_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA134866755	http://www.pharmgkb.org/do/serve?objId=PA134866755&objCls=Gene
Phobius	swissprot:5HT3D_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:5HT3D_HUMAN
PhylomeDB	Q70Z44	http://phylomedb.org/?seqid=Q70Z44
ProteinModelPortal	Q70Z44	http://www.proteinmodelportal.org/query/uniprot/Q70Z44
PubMed	12801637	http://www.ncbi.nlm.nih.gov/pubmed/12801637
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	17392525	http://www.ncbi.nlm.nih.gov/pubmed/17392525
Reactome	R-HSA-975298	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-975298
RefSeq	NP_001138615	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001138615
RefSeq	NP_001157118	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001157118
RefSeq	NP_872343	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_872343
RefSeq	XP_016861343	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016861343
STRING	9606.ENSP00000371929	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000371929&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TCDB	1.A.9.2	http://www.tcdb.org/search/result.php?tc=1.A.9.2
UCSC	uc010hxp	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010hxp&org=rat
UniGene	Hs.448004	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.448004
UniProtKB	5HT3D_HUMAN	http://www.uniprot.org/uniprot/5HT3D_HUMAN
UniProtKB-AC	Q70Z44	http://www.uniprot.org/uniprot/Q70Z44
charge	swissprot:5HT3D_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:5HT3D_HUMAN
eggNOG	ENOG410XQGR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQGR
eggNOG	KOG3645	http://eggnogapi.embl.de/nog_data/html/tree/KOG3645
epestfind	swissprot:5HT3D_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:5HT3D_HUMAN
garnier	swissprot:5HT3D_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:5HT3D_HUMAN
helixturnhelix	swissprot:5HT3D_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:5HT3D_HUMAN
hmoment	swissprot:5HT3D_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:5HT3D_HUMAN
iep	swissprot:5HT3D_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:5HT3D_HUMAN
inforesidue	swissprot:5HT3D_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:5HT3D_HUMAN
neXtProt	NX_Q70Z44	http://www.nextprot.org/db/entry/NX_Q70Z44
octanol	swissprot:5HT3D_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:5HT3D_HUMAN
pepcoil	swissprot:5HT3D_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:5HT3D_HUMAN
pepdigest	swissprot:5HT3D_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:5HT3D_HUMAN
pepinfo	swissprot:5HT3D_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:5HT3D_HUMAN
pepnet	swissprot:5HT3D_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:5HT3D_HUMAN
pepstats	swissprot:5HT3D_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:5HT3D_HUMAN
pepwheel	swissprot:5HT3D_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:5HT3D_HUMAN
pepwindow	swissprot:5HT3D_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:5HT3D_HUMAN
sigcleave	swissprot:5HT3D_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:5HT3D_HUMAN
## Database	ID	URL or Descriptions
# AltName	S35A4_HUMAN	Solute carrier family 35 member A4
# ChiTaRS	SLC35A4	human
# Ensembl	ENST00000323146	ENSP00000327133; ENSG00000176087
# Ensembl	ENST00000514199	ENSP00000424566; ENSG00000176087
# Ensembl	ENST00000612662	ENSP00000479255; ENSG00000176087
# ExpressionAtlas	Q96G79	baseline and differential
# GO_component	GO:0000139	Golgi membrane; IEA:InterPro.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	S35A4_HUMAN	GO 0005351 sugar proton symporter activity; IEA InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# Genevisible	Q96G79	HS
# HGNC	HGNC:20753	SLC35A4
# InterPro	IPR007271	Nuc_sug_transpt
# KEGG_Brite	ko02001	Solute carrier family
# MISCELLANEOUS	S35A4_HUMAN	Classified as NST family 1 subfamily D in a phylogenic study. Family 1 seems to be the most recent in evolution. 
# Organism	S35A4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10231	PTHR10231
# PIRSF	PIRSF005799	UDP-gal_transpt
# Pfam	PF04142	Nuc_sug_transp
# Proteomes	UP000005640	Chromosome 5
# RecName	S35A4_HUMAN	Probable UDP-sugar transporter protein SLC35A4
# RefSeq	NP_542401	NM_080670.3
# SIMILARITY	Belongs to the nucleotide-sugar transporter family. SLC35A subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	S35A4_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. Golgi apparatus {ECO 0000250}. 
# TCDB	2.A.7.12.12	the drug/metabolite transporter (dmt) superfamily
# UCSC	uc003lgg	human
# eggNOG	COG0697	LUCA
# eggNOG	KOG2234	Eukaryota
BLAST	swissprot:S35A4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S35A4_HUMAN
BioCyc	ZFISH:ENSG00000176087-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000176087-MONOMER
COXPRESdb	113829	http://coxpresdb.jp/data/gene/113829.shtml
CleanEx	HS_SLC35A4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC35A4
DOI	10.1016/S0300-9084(03)00046-4	http://dx.doi.org/10.1016/S0300-9084(03)00046-4
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AK289378	http://www.ebi.ac.uk/ena/data/view/AK289378
EMBL	AL833972	http://www.ebi.ac.uk/ena/data/view/AL833972
EMBL	BC009906	http://www.ebi.ac.uk/ena/data/view/BC009906
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
Ensembl	ENST00000323146	http://www.ensembl.org/id/ENST00000323146
Ensembl	ENST00000514199	http://www.ensembl.org/id/ENST00000514199
Ensembl	ENST00000612662	http://www.ensembl.org/id/ENST00000612662
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005351	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005351
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GeneCards	SLC35A4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC35A4
GeneID	113829	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=113829
GeneTree	ENSGT00550000074563	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074563
HGNC	HGNC:20753	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20753
HOGENOM	HOG000154235	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000154235&db=HOGENOM6
HOVERGEN	HBG108445	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108445&db=HOVERGEN
HPA	HPA062210	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA062210
InParanoid	Q96G79	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96G79
IntAct	Q96G79	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96G79*
InterPro	IPR007271	http://www.ebi.ac.uk/interpro/entry/IPR007271
Jabion	113829	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=113829
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:113829	http://www.genome.jp/dbget-bin/www_bget?hsa:113829
KEGG_Orthology	KO:K15273	http://www.genome.jp/dbget-bin/www_bget?KO:K15273
OMA	ALCHVNG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ALCHVNG
OrthoDB	EOG091G0BN0	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0BN0
PANTHER	PTHR10231	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10231
PSORT	swissprot:S35A4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S35A4_HUMAN
PSORT-B	swissprot:S35A4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S35A4_HUMAN
PSORT2	swissprot:S35A4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S35A4_HUMAN
Pfam	PF04142	http://pfam.xfam.org/family/PF04142
PharmGKB	PA134971555	http://www.pharmgkb.org/do/serve?objId=PA134971555&objCls=Gene
Phobius	swissprot:S35A4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S35A4_HUMAN
PhylomeDB	Q96G79	http://phylomedb.org/?seqid=Q96G79
ProteinModelPortal	Q96G79	http://www.proteinmodelportal.org/query/uniprot/Q96G79
PubMed	12770764	http://www.ncbi.nlm.nih.gov/pubmed/12770764
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
RefSeq	NP_542401	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_542401
STRING	9606.ENSP00000327133	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000327133&targetmode=cogs
TCDB	2.A.7.12.12	http://www.tcdb.org/search/result.php?tc=2.A.7.12.12
UCSC	uc003lgg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003lgg&org=rat
UniGene	Hs.406840	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.406840
UniProtKB	S35A4_HUMAN	http://www.uniprot.org/uniprot/S35A4_HUMAN
UniProtKB-AC	Q96G79	http://www.uniprot.org/uniprot/Q96G79
charge	swissprot:S35A4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S35A4_HUMAN
eggNOG	COG0697	http://eggnogapi.embl.de/nog_data/html/tree/COG0697
eggNOG	KOG2234	http://eggnogapi.embl.de/nog_data/html/tree/KOG2234
epestfind	swissprot:S35A4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S35A4_HUMAN
garnier	swissprot:S35A4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S35A4_HUMAN
helixturnhelix	swissprot:S35A4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S35A4_HUMAN
hmoment	swissprot:S35A4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S35A4_HUMAN
iep	swissprot:S35A4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S35A4_HUMAN
inforesidue	swissprot:S35A4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S35A4_HUMAN
neXtProt	NX_Q96G79	http://www.nextprot.org/db/entry/NX_Q96G79
octanol	swissprot:S35A4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S35A4_HUMAN
pepcoil	swissprot:S35A4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S35A4_HUMAN
pepdigest	swissprot:S35A4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S35A4_HUMAN
pepinfo	swissprot:S35A4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S35A4_HUMAN
pepnet	swissprot:S35A4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S35A4_HUMAN
pepstats	swissprot:S35A4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S35A4_HUMAN
pepwheel	swissprot:S35A4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S35A4_HUMAN
pepwindow	swissprot:S35A4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S35A4_HUMAN
sigcleave	swissprot:S35A4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S35A4_HUMAN
## Database	ID	URL or Descriptions
# CAUTION	Could be the product of a pseudogene. {ECO	0000305}.
# CDD	cd00333	MIP
# DOMAIN	AQP73_HUMAN	Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro/Ala-Ala/Ser (NPA). 
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0015204	urea transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015250	water channel activity; IBA:GO_Central.
# GO_function	GO:0015254	glycerol channel activity; IBA:GO_Central.
# GO_process	GO:0009992	cellular water homeostasis; IBA:GO_Central.
# GO_process	GO:0034219	carbohydrate transmembrane transport; IBA:GO_Central.
# GO_process	GO:0034220	ion transmembrane transport; IBA:GO_Central.
# GO_process	GO:0071918	urea transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.1080.10	-; 1.
# HGNC	HGNC:31976	AQP7P3
# InterPro	IPR000425	MIP
# InterPro	IPR015686	Aquaporin_7
# InterPro	IPR023271	Aquaporin-like
# Organism	AQP73_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR19139	PTHR19139
# PANTHER	PTHR19139:SF16	PTHR19139:SF16
# PRINTS	PR00783	MINTRINSICP
# Pfam	PF00230	MIP
# Proteomes	UP000005640	Unplaced
# RecName	AQP73_HUMAN	Putative aquaporin-7-like protein 3
# SIMILARITY	Belongs to the MIP/aquaporin (TC 1.A.8) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	AQP73_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF81338	SSF81338
# TIGRFAMs	TIGR00861	MIP
BLAST	swissprot:AQP73_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AQP73_HUMAN
BioCyc	ZFISH:G66-31218-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31218-MONOMER
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
EMBL	AC129778	http://www.ebi.ac.uk/ena/data/view/AC129778
EMBL	AL136317	http://www.ebi.ac.uk/ena/data/view/AL136317
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0015204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015204
GO_function	GO:0015250	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015250
GO_function	GO:0015254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015254
GO_process	GO:0009992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009992
GO_process	GO:0034219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034219
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0071918	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071918
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.1080.10	http://www.cathdb.info/version/latest/superfamily/1.20.1080.10
GeneCards	AQP7P3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=AQP7P3
HGNC	HGNC:31976	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:31976
HOVERGEN	HBG106057	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG106057&db=HOVERGEN
InParanoid	A6NL99	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=A6NL99
InterPro	IPR000425	http://www.ebi.ac.uk/interpro/entry/IPR000425
InterPro	IPR015686	http://www.ebi.ac.uk/interpro/entry/IPR015686
InterPro	IPR023271	http://www.ebi.ac.uk/interpro/entry/IPR023271
PANTHER	PTHR19139	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19139
PANTHER	PTHR19139:SF16	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19139:SF16
PRINTS	PR00783	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00783
PSORT	swissprot:AQP73_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AQP73_HUMAN
PSORT-B	swissprot:AQP73_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AQP73_HUMAN
PSORT2	swissprot:AQP73_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AQP73_HUMAN
Pfam	PF00230	http://pfam.xfam.org/family/PF00230
Phobius	swissprot:AQP73_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AQP73_HUMAN
PhylomeDB	A6NL99	http://phylomedb.org/?seqid=A6NL99
ProteinModelPortal	A6NL99	http://www.proteinmodelportal.org/query/uniprot/A6NL99
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
SUPFAM	SSF81338	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81338
TIGRFAMs	TIGR00861	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00861
UniGene	Hs.743215	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.743215
UniProtKB	AQP73_HUMAN	http://www.uniprot.org/uniprot/AQP73_HUMAN
UniProtKB-AC	A6NL99	http://www.uniprot.org/uniprot/A6NL99
charge	swissprot:AQP73_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AQP73_HUMAN
epestfind	swissprot:AQP73_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AQP73_HUMAN
garnier	swissprot:AQP73_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AQP73_HUMAN
helixturnhelix	swissprot:AQP73_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AQP73_HUMAN
hmoment	swissprot:AQP73_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AQP73_HUMAN
iep	swissprot:AQP73_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AQP73_HUMAN
inforesidue	swissprot:AQP73_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AQP73_HUMAN
neXtProt	NX_A6NL99	http://www.nextprot.org/db/entry/NX_A6NL99
octanol	swissprot:AQP73_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AQP73_HUMAN
pepcoil	swissprot:AQP73_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AQP73_HUMAN
pepdigest	swissprot:AQP73_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AQP73_HUMAN
pepinfo	swissprot:AQP73_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AQP73_HUMAN
pepnet	swissprot:AQP73_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AQP73_HUMAN
pepstats	swissprot:AQP73_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AQP73_HUMAN
pepwheel	swissprot:AQP73_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AQP73_HUMAN
pepwindow	swissprot:AQP73_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AQP73_HUMAN
sigcleave	swissprot:AQP73_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AQP73_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TMCO3_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6UWJ1-1; Sequence=Displayed; Name=2; IsoId=Q6UWJ1-2; Sequence=VSP_020563, VSP_020564; Note=No experimental confirmation available.; Name=3; IsoId=Q6UWJ1-3; Sequence=VSP_020561, VSP_020562; Note=No experimental confirmation available.; 
# AltName	TMCO3_HUMAN	Putative LAG1-interacting protein
# BioGrid	120334	38
# CCDS	CCDS9537	-. [Q6UWJ1-1]
# ChiTaRS	TMCO3	human
# Ensembl	ENST00000375391	ENSP00000364540; ENSG00000150403. [Q6UWJ1-3]
# Ensembl	ENST00000434316	ENSP00000389399; ENSG00000150403. [Q6UWJ1-1]
# Ensembl	ENST00000474393	ENSP00000484053; ENSG00000150403. [Q6UWJ1-2]
# ExpressionAtlas	Q6UWJ1	baseline and differential
# FUNCTION	TMCO3_HUMAN	Probable Na(+)/H(+) antiporter. {ECO 0000250}. 
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	TMCO3_HUMAN	GO 0015299 solute proton antiporter activity; IEA InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# Genevisible	Q6UWJ1	HS
# HGNC	HGNC:20329	TMCO3
# IntAct	Q6UWJ1	4
# InterPro	IPR006153	Cation/H_exchanger
# MIM	617134	gene
# Organism	TMCO3_HUMAN	Homo sapiens (Human)
# Pfam	PF00999	Na_H_Exchanger
# Proteomes	UP000005640	Chromosome 13
# RecName	TMCO3_HUMAN	Transmembrane and coiled-coil domain-containing protein 3
# RefSeq	NP_060375	NM_017905.4. [Q6UWJ1-1]
# RefSeq	XP_006720032	XM_006719969.1. [Q6UWJ1-1]
# RefSeq	XP_011535800	XM_011537498.2. [Q6UWJ1-1]
# SEQUENCE CAUTION	Sequence=AAM92892.1; Type=Frameshift; Positions=367, 378; Evidence={ECO:0000305}; Sequence=BAB85074.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	TMCO3_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	2.A.37.1.11:the monovalent cation	proton antiporter-2 (cpa2) family
# TISSUE SPECIFICITY	Expressed in the cornea, lens capsule and choroid-retinal pigment epithelium (at protein level). {ECO:0000269|PubMed	27484837}. 
# UCSC	uc001vtt	human. [Q6UWJ1-1]
# eggNOG	COG0475	LUCA
# eggNOG	KOG1650	Eukaryota
BLAST	swissprot:TMCO3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TMCO3_HUMAN
COXPRESdb	55002	http://coxpresdb.jp/data/gene/55002.shtml
CleanEx	HS_TMCO3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TMCO3
DOI	10.1038/nature02379	http://dx.doi.org/10.1038/nature02379
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/srep31021	http://dx.doi.org/10.1038/srep31021
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF209505	http://www.ebi.ac.uk/ena/data/view/AF209505
EMBL	AK000630	http://www.ebi.ac.uk/ena/data/view/AK000630
EMBL	AK074415	http://www.ebi.ac.uk/ena/data/view/AK074415
EMBL	AL442125	http://www.ebi.ac.uk/ena/data/view/AL442125
EMBL	AL442125	http://www.ebi.ac.uk/ena/data/view/AL442125
EMBL	AY358768	http://www.ebi.ac.uk/ena/data/view/AY358768
EMBL	BC012564	http://www.ebi.ac.uk/ena/data/view/BC012564
EMBL	BC068515	http://www.ebi.ac.uk/ena/data/view/BC068515
Ensembl	ENST00000375391	http://www.ensembl.org/id/ENST00000375391
Ensembl	ENST00000434316	http://www.ensembl.org/id/ENST00000434316
Ensembl	ENST00000474393	http://www.ensembl.org/id/ENST00000474393
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015299	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015299
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GeneCards	TMCO3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TMCO3
GeneID	55002	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55002
GeneTree	ENSGT00390000001394	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000001394
HGNC	HGNC:20329	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20329
HOVERGEN	HBG094066	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG094066&db=HOVERGEN
HPA	HPA039561	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA039561
HPA	HPA048126	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA048126
InParanoid	Q6UWJ1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6UWJ1
IntAct	Q6UWJ1	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q6UWJ1*
InterPro	IPR006153	http://www.ebi.ac.uk/interpro/entry/IPR006153
Jabion	55002	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55002
KEGG_Gene	hsa:55002	http://www.genome.jp/dbget-bin/www_bget?hsa:55002
MIM	617134	http://www.ncbi.nlm.nih.gov/omim/617134
OMA	VVMKFLL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VVMKFLL
OrthoDB	EOG091G03W2	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G03W2
PSORT	swissprot:TMCO3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TMCO3_HUMAN
PSORT-B	swissprot:TMCO3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TMCO3_HUMAN
PSORT2	swissprot:TMCO3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TMCO3_HUMAN
Pfam	PF00999	http://pfam.xfam.org/family/PF00999
PharmGKB	PA134989495	http://www.pharmgkb.org/do/serve?objId=PA134989495&objCls=Gene
Phobius	swissprot:TMCO3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TMCO3_HUMAN
PhylomeDB	Q6UWJ1	http://phylomedb.org/?seqid=Q6UWJ1
ProteinModelPortal	Q6UWJ1	http://www.proteinmodelportal.org/query/uniprot/Q6UWJ1
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15057823	http://www.ncbi.nlm.nih.gov/pubmed/15057823
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	27484837	http://www.ncbi.nlm.nih.gov/pubmed/27484837
RefSeq	NP_060375	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060375
RefSeq	XP_006720032	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006720032
RefSeq	XP_011535800	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011535800
SMR	Q6UWJ1	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q6UWJ1
STRING	9606.ENSP00000389399	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000389399&targetmode=cogs
TCDB	2.A.37.1.11	http://www.tcdb.org/search/result.php?tc=2.A.37.1.11
UCSC	uc001vtt	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001vtt&org=rat
UniGene	Hs.317593	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.317593
UniProtKB	TMCO3_HUMAN	http://www.uniprot.org/uniprot/TMCO3_HUMAN
UniProtKB-AC	Q6UWJ1	http://www.uniprot.org/uniprot/Q6UWJ1
charge	swissprot:TMCO3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TMCO3_HUMAN
eggNOG	COG0475	http://eggnogapi.embl.de/nog_data/html/tree/COG0475
eggNOG	KOG1650	http://eggnogapi.embl.de/nog_data/html/tree/KOG1650
epestfind	swissprot:TMCO3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TMCO3_HUMAN
garnier	swissprot:TMCO3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TMCO3_HUMAN
helixturnhelix	swissprot:TMCO3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TMCO3_HUMAN
hmoment	swissprot:TMCO3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TMCO3_HUMAN
iep	swissprot:TMCO3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TMCO3_HUMAN
inforesidue	swissprot:TMCO3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TMCO3_HUMAN
neXtProt	NX_Q6UWJ1	http://www.nextprot.org/db/entry/NX_Q6UWJ1
octanol	swissprot:TMCO3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TMCO3_HUMAN
pepcoil	swissprot:TMCO3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TMCO3_HUMAN
pepdigest	swissprot:TMCO3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TMCO3_HUMAN
pepinfo	swissprot:TMCO3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TMCO3_HUMAN
pepnet	swissprot:TMCO3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TMCO3_HUMAN
pepstats	swissprot:TMCO3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TMCO3_HUMAN
pepwheel	swissprot:TMCO3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TMCO3_HUMAN
pepwindow	swissprot:TMCO3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TMCO3_HUMAN
sigcleave	swissprot:TMCO3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TMCO3_HUMAN
## Database	ID	URL or Descriptions
# AltName	ZNT1_HUMAN	Solute carrier family 30 member 1
# BioGrid	113560	20
# Ensembl	ENST00000367001	ENSP00000355968; ENSG00000170385
# FUNCTION	ZNT1_HUMAN	May be involved in zinc transport out of the cell. 
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005783	endoplasmic reticulum; IDA:UniProtKB.
# GO_component	GO:0005794	Golgi apparatus; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0030315	T-tubule; ISS:BHF-UCL.
# GO_component	GO:0031965	nuclear membrane; IDA:UniProtKB.
# GO_function	GO:0005385	zinc ion transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0019855	calcium channel inhibitor activity; ISS:BHF-UCL.
# GO_process	GO:0001701	in utero embryonic development; IEA:Ensembl.
# GO_process	GO:0006829	zinc II ion transport; ISS:BHF-UCL.
# GO_process	GO:0006874	cellular calcium ion homeostasis; ISS:BHF-UCL.
# GO_process	GO:0006882	cellular zinc ion homeostasis; ISS:BHF-UCL.
# GO_process	GO:0010043	response to zinc ion; IBA:GO_Central.
# GO_process	GO:0046929	negative regulation of neurotransmitter secretion; ISS:BHF-UCL.
# GO_process	GO:0061088	regulation of sequestering of zinc ion; IBA:GO_Central.
# GO_process	GO:0070509	calcium ion import; IEA:Ensembl.
# GO_process	GO:0070574	cadmium ion transmembrane transport; ISS:BHF-UCL.
# GO_process	GO:0071584	negative regulation of zinc ion transmembrane import; ISS:BHF-UCL.
# GO_process	GO:0071585	detoxification of cadmium ion; IEA:Ensembl.
# GO_process	GO:0090281	negative regulation of calcium ion import; ISS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009790	embryo development
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.1510.10	-; 3.
# Genevisible	Q9Y6M5	HS
# HGNC	HGNC:11012	SLC30A1
# IntAct	Q9Y6M5	4
# InterPro	IPR002524	Cation_efflux
# InterPro	IPR027469	Cation_efflux_TMD
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04978	Mineral absorption
# MIM	609521	gene
# Organism	ZNT1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11562	PTHR11562; 3
# Pfam	PF01545	Cation_efflux
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-435368	Zinc efflux and compartmentalization by the SLC30 family
# RecName	ZNT1_HUMAN	Zinc transporter 1
# RefSeq	NP_067017	NM_021194.2
# SIMILARITY	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	ZNT1_HUMAN	Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUBUNIT	Multimer. {ECO	0000305}. 
# TCDB	2.A.4.2	the cation diffusion facilitator (cdf) family
# TIGRFAMs	TIGR01297	CDF
# UCSC	uc001hio	human
# eggNOG	COG1230	LUCA
# eggNOG	KOG1483	Eukaryota
BLAST	swissprot:ZNT1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ZNT1_HUMAN
BioCyc	ZFISH:ENSG00000170385-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000170385-MONOMER
COG	COG1230	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1230
COXPRESdb	7779	http://coxpresdb.jp/data/gene/7779.shtml
CleanEx	HS_SLC30A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC30A1
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
EMBL	AB451467	http://www.ebi.ac.uk/ena/data/view/AB451467
EMBL	AF048701	http://www.ebi.ac.uk/ena/data/view/AF048701
EMBL	AF323590	http://www.ebi.ac.uk/ena/data/view/AF323590
EMBL	BC121015	http://www.ebi.ac.uk/ena/data/view/BC121015
EMBL	BC121016	http://www.ebi.ac.uk/ena/data/view/BC121016
EMBL	CH471100	http://www.ebi.ac.uk/ena/data/view/CH471100
Ensembl	ENST00000367001	http://www.ensembl.org/id/ENST00000367001
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030315
GO_component	GO:0031965	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031965
GO_function	GO:0005385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005385
GO_function	GO:0019855	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019855
GO_process	GO:0001701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001701
GO_process	GO:0006829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006829
GO_process	GO:0006874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874
GO_process	GO:0006882	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006882
GO_process	GO:0010043	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010043
GO_process	GO:0046929	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046929
GO_process	GO:0061088	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061088
GO_process	GO:0070509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070509
GO_process	GO:0070574	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070574
GO_process	GO:0071584	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071584
GO_process	GO:0071585	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071585
GO_process	GO:0090281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090281
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009790
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.1510.10	http://www.cathdb.info/version/latest/superfamily/1.20.1510.10
GeneCards	SLC30A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC30A1
GeneID	7779	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7779
GeneTree	ENSGT00550000074381	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074381
HGNC	HGNC:11012	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11012
HOGENOM	HOG000166089	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000166089&db=HOGENOM6
HOVERGEN	HBG000588	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000588&db=HOVERGEN
HPA	HPA015275	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA015275
HPA	HPA049000	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA049000
InParanoid	Q9Y6M5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y6M5
IntAct	Q9Y6M5	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9Y6M5*
InterPro	IPR002524	http://www.ebi.ac.uk/interpro/entry/IPR002524
InterPro	IPR027469	http://www.ebi.ac.uk/interpro/entry/IPR027469
Jabion	7779	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7779
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:7779	http://www.genome.jp/dbget-bin/www_bget?hsa:7779
KEGG_Orthology	KO:K14688	http://www.genome.jp/dbget-bin/www_bget?KO:K14688
KEGG_Pathway	ko04978	http://www.genome.jp/kegg-bin/show_pathway?ko04978
MIM	609521	http://www.ncbi.nlm.nih.gov/omim/609521
OMA	HHHSGFS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HHHSGFS
OrthoDB	EOG091G08R5	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08R5
PANTHER	PTHR11562	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11562
PSORT	swissprot:ZNT1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ZNT1_HUMAN
PSORT-B	swissprot:ZNT1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ZNT1_HUMAN
PSORT2	swissprot:ZNT1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ZNT1_HUMAN
Pfam	PF01545	http://pfam.xfam.org/family/PF01545
PharmGKB	PA35882	http://www.pharmgkb.org/do/serve?objId=PA35882&objCls=Gene
Phobius	swissprot:ZNT1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ZNT1_HUMAN
PhylomeDB	Q9Y6M5	http://phylomedb.org/?seqid=Q9Y6M5
ProteinModelPortal	Q9Y6M5	http://www.proteinmodelportal.org/query/uniprot/Q9Y6M5
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
Reactome	R-HSA-435368	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-435368
RefSeq	NP_067017	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_067017
STRING	9606.ENSP00000355968	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000355968&targetmode=cogs
STRING	COG1230	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1230&targetmode=cogs
TCDB	2.A.4.2	http://www.tcdb.org/search/result.php?tc=2.A.4.2
TIGRFAMs	TIGR01297	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01297
UCSC	uc001hio	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001hio&org=rat
UniGene	Hs.519469	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.519469
UniProtKB	ZNT1_HUMAN	http://www.uniprot.org/uniprot/ZNT1_HUMAN
UniProtKB-AC	Q9Y6M5	http://www.uniprot.org/uniprot/Q9Y6M5
charge	swissprot:ZNT1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ZNT1_HUMAN
eggNOG	COG1230	http://eggnogapi.embl.de/nog_data/html/tree/COG1230
eggNOG	KOG1483	http://eggnogapi.embl.de/nog_data/html/tree/KOG1483
epestfind	swissprot:ZNT1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ZNT1_HUMAN
garnier	swissprot:ZNT1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ZNT1_HUMAN
helixturnhelix	swissprot:ZNT1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZNT1_HUMAN
hmoment	swissprot:ZNT1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ZNT1_HUMAN
iep	swissprot:ZNT1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ZNT1_HUMAN
inforesidue	swissprot:ZNT1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ZNT1_HUMAN
neXtProt	NX_Q9Y6M5	http://www.nextprot.org/db/entry/NX_Q9Y6M5
octanol	swissprot:ZNT1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ZNT1_HUMAN
pepcoil	swissprot:ZNT1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ZNT1_HUMAN
pepdigest	swissprot:ZNT1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ZNT1_HUMAN
pepinfo	swissprot:ZNT1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ZNT1_HUMAN
pepnet	swissprot:ZNT1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ZNT1_HUMAN
pepstats	swissprot:ZNT1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ZNT1_HUMAN
pepwheel	swissprot:ZNT1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ZNT1_HUMAN
pepwindow	swissprot:ZNT1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ZNT1_HUMAN
sigcleave	swissprot:ZNT1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ZNT1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A6NK97-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=A6NK97-2; Sequence=VSP_032653, VSP_032654; Note=Variant in position: 244	G->G (in dbSNP:rs514076).; 
# AltName	S22AK_HUMAN	Organic anion transporter 6
# CDD	cd06174	MFS
# FUNCTION	S22AK_HUMAN	Organic anion transporter that mediates the uptake of estrone sulfate. Inhibited by probenecid, propionate, 2- methylbutyrate, 3-methylbutyrate, benzoate, heptanoate and 2- ethylhaxanoate. May act as an odorant transporter (By similarity). {ECO 0000250}. 
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0005452	inorganic anion exchanger activity; IBA:GO_Central.
# GO_function	GO:0015347	sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0043252	sodium-independent organic anion transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# HGNC	HGNC:29867	SLC22A20
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	611696	gene
# Organism	S22AK_HUMAN	Homo sapiens (Human)
# PROSITE	PS50850	MFS
# Pfam	PF00083	Sugar_tr
# Proteomes	UP000005640	Unplaced
# RecName	S22AK_HUMAN	Solute carrier family 22 member 20
# RefSeq	NP_001004326	NM_001004326.4
# SEQUENCE CAUTION	Sequence=BAD18487.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S22AK_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.19.35	the major facilitator superfamily (mfs)
BLAST	swissprot:S22AK_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S22AK_HUMAN
BioCyc	ZFISH:G66-32933-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32933-MONOMER
COXPRESdb	440044	http://coxpresdb.jp/data/gene/440044.shtml
CleanEx	HS_SLC22A20	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC22A20
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AK131327	http://www.ebi.ac.uk/ena/data/view/AK131327
EMBL	AP003068	http://www.ebi.ac.uk/ena/data/view/AP003068
EMBL	BC146850	http://www.ebi.ac.uk/ena/data/view/BC146850
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005452	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005452
GO_function	GO:0015347	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015347
GO_process	GO:0043252	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043252
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC22A20	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC22A20
GeneID	440044	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=440044
HGNC	HGNC:29867	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:29867
HOGENOM	HOG000234569	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234569&db=HOGENOM6
HOVERGEN	HBG108433	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108433&db=HOVERGEN
InParanoid	A6NK97	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=A6NK97
IntAct	A6NK97	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=A6NK97*
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	440044	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=440044
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:440044	http://www.genome.jp/dbget-bin/www_bget?hsa:440044
KEGG_Orthology	KO:K08216	http://www.genome.jp/dbget-bin/www_bget?KO:K08216
MIM	611696	http://www.ncbi.nlm.nih.gov/omim/611696
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:S22AK_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S22AK_HUMAN
PSORT-B	swissprot:S22AK_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S22AK_HUMAN
PSORT2	swissprot:S22AK_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S22AK_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
PharmGKB	PA162403493	http://www.pharmgkb.org/do/serve?objId=PA162403493&objCls=Gene
Phobius	swissprot:S22AK_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S22AK_HUMAN
PhylomeDB	A6NK97	http://phylomedb.org/?seqid=A6NK97
ProteinModelPortal	A6NK97	http://www.proteinmodelportal.org/query/uniprot/A6NK97
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
RefSeq	NP_001004326	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001004326
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.19.35	http://www.tcdb.org/search/result.php?tc=2.A.1.19.35
UniGene	Hs.532372	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.532372
UniProtKB	S22AK_HUMAN	http://www.uniprot.org/uniprot/S22AK_HUMAN
UniProtKB-AC	A6NK97	http://www.uniprot.org/uniprot/A6NK97
charge	swissprot:S22AK_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S22AK_HUMAN
epestfind	swissprot:S22AK_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S22AK_HUMAN
garnier	swissprot:S22AK_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S22AK_HUMAN
helixturnhelix	swissprot:S22AK_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S22AK_HUMAN
hmoment	swissprot:S22AK_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S22AK_HUMAN
iep	swissprot:S22AK_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S22AK_HUMAN
inforesidue	swissprot:S22AK_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S22AK_HUMAN
neXtProt	NX_A6NK97	http://www.nextprot.org/db/entry/NX_A6NK97
octanol	swissprot:S22AK_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S22AK_HUMAN
pepcoil	swissprot:S22AK_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S22AK_HUMAN
pepdigest	swissprot:S22AK_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S22AK_HUMAN
pepinfo	swissprot:S22AK_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S22AK_HUMAN
pepnet	swissprot:S22AK_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S22AK_HUMAN
pepstats	swissprot:S22AK_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S22AK_HUMAN
pepwheel	swissprot:S22AK_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S22AK_HUMAN
pepwindow	swissprot:S22AK_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S22AK_HUMAN
sigcleave	swissprot:S22AK_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S22AK_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	MRP7_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Mrp7; IsoId=Q5T3U5-1; Sequence=Displayed; Name=2; Synonyms=Mrp7A; IsoId=Q5T3U5-2; Sequence=VSP_021078, VSP_021079, VSP_021080; 
# AltName	MRP7_HUMAN	ATP-binding cassette sub-family C member 10
# BIOPHYSICOCHEMICAL PROPERTIES	MRP7_HUMAN	Kinetic parameters  KM=57.8 uM for 17-beta-estradiol 17-(beta-D-glucuronide) (at 37 degrees Celsius) {ECO 0000269|PubMed 12527806}; Vmax=20 pmol/min/mg enzyme toward 17-beta-estradiol 17-(beta-D- glucuronide) (at 37 degrees Celsius) {ECO 0000269|PubMed 12527806}; 
# BioGrid	124617	9
# CCDS	CCDS4896	-. [Q5T3U5-2]
# CCDS	CCDS56430	-. [Q5T3U5-1]
# ChiTaRS	ABCC10	human
# DrugBank	DB00091	Cyclosporine
# DrugBank	DB00203	Sildenafil
# DrugBank	DB00300	Tenofovir
# DrugBank	DB00441	Gemcitabine
# DrugBank	DB00541	Vincristine
# DrugBank	DB00563	Methotrexate
# DrugBank	DB00661	Verapamil
# DrugBank	DB00694	Daunorubicin
# DrugBank	DB00773	Etoposide
# DrugBank	DB00783	Estradiol
# DrugBank	DB00987	Cytarabine
# DrugBank	DB00997	Doxorubicin
# DrugBank	DB01229	Paclitaxel
# DrugBank	DB01248	Docetaxel
# Ensembl	ENST00000244533	ENSP00000244533; ENSG00000124574. [Q5T3U5-2]
# Ensembl	ENST00000372530	ENSP00000361608; ENSG00000124574. [Q5T3U5-1]
# ExpressionAtlas	Q5T3U5	baseline and differential
# FUNCTION	MRP7_HUMAN	ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion. {ECO 0000269|PubMed 12527806, ECO 0000269|PubMed 15256465}. 
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0043225	ATPase-coupled anion transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 2.
# Genevisible	Q5T3U5	HS
# HGNC	HGNC:52	ABCC10
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR011527	ABC1_TM_dom
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR027417	P-loop_NTPase
# InterPro	IPR030249	ABCC10
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko02010	ABC transporters
# MIM	612509	gene
# Organism	MRP7_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR24223:SF235	PTHR24223:SF235; 2
# PIR	T43469	T43469
# PROSITE	PS00211	ABC_TRANSPORTER_1; 2
# PROSITE	PS50893	ABC_TRANSPORTER_2; 2
# PROSITE	PS50929	ABC_TM1F; 2
# Pfam	PF00005	ABC_tran; 2
# Pfam	PF00664	ABC_membrane; 2
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-382556	ABC-family proteins mediated transport
# RecName	MRP7_HUMAN	Multidrug resistance-associated protein 7
# RefSeq	NP_001185863	NM_001198934.1. [Q5T3U5-1]
# RefSeq	NP_258261	NM_033450.2. [Q5T3U5-2]
# SEQUENCE CAUTION	Sequence=BAA92227.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15736.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 2 ABC transmembrane type-1 domains. {ECO:0000255|PROSITE-ProRule	PRU00441}. 
# SIMILARITY	Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA; 2
# SUBCELLULAR LOCATION	MRP7_HUMAN	Cell membrane {ECO 0000269|PubMed 12566991, ECO 0000269|PubMed 15256465}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00441, ECO 0000269|PubMed 12566991, ECO 0000269|PubMed 15256465}. 
# SUPFAM	SSF52540	SSF52540; 2
# SUPFAM	SSF90123	SSF90123; 2
# TCDB	3.A.1.208.31	the atp-binding cassette (abc) superfamily
# TISSUE SPECIFICITY	Isoform 1 is specifically expressed in spleen. Isoform 2 is more widely expressed. {ECO:0000269|PubMed	12566991}. 
# UCSC	uc003ouy	human. [Q5T3U5-1]
# WEB RESOURCE	MRP7_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=Q5T3U5";
# eggNOG	COG1132	LUCA
# eggNOG	KOG0054	Eukaryota
BLAST	swissprot:MRP7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MRP7_HUMAN
COXPRESdb	89845	http://coxpresdb.jp/data/gene/89845.shtml
CleanEx	HS_ABCC10	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCC10
DOI	10.1007/BF02256002	http://dx.doi.org/10.1007/BF02256002
DOI	10.1021/pr0705441	http://dx.doi.org/10.1021/pr0705441
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1093/dnares/7.6.357	http://dx.doi.org/10.1093/dnares/7.6.357
DOI	10.1124/mol.63.2.351	http://dx.doi.org/10.1124/mol.63.2.351
DOI	10.1158/0008-5472.CAN-03-3111	http://dx.doi.org/10.1158/0008-5472.CAN-03-3111
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DrugBank	DB00091	http://www.drugbank.ca/drugs/DB00091
DrugBank	DB00203	http://www.drugbank.ca/drugs/DB00203
DrugBank	DB00300	http://www.drugbank.ca/drugs/DB00300
DrugBank	DB00441	http://www.drugbank.ca/drugs/DB00441
DrugBank	DB00541	http://www.drugbank.ca/drugs/DB00541
DrugBank	DB00563	http://www.drugbank.ca/drugs/DB00563
DrugBank	DB00661	http://www.drugbank.ca/drugs/DB00661
DrugBank	DB00694	http://www.drugbank.ca/drugs/DB00694
DrugBank	DB00773	http://www.drugbank.ca/drugs/DB00773
DrugBank	DB00783	http://www.drugbank.ca/drugs/DB00783
DrugBank	DB00987	http://www.drugbank.ca/drugs/DB00987
DrugBank	DB00997	http://www.drugbank.ca/drugs/DB00997
DrugBank	DB01229	http://www.drugbank.ca/drugs/DB01229
DrugBank	DB01248	http://www.drugbank.ca/drugs/DB01248
EMBL	AK000002	http://www.ebi.ac.uk/ena/data/view/AK000002
EMBL	AK024446	http://www.ebi.ac.uk/ena/data/view/AK024446
EMBL	AL133613	http://www.ebi.ac.uk/ena/data/view/AL133613
EMBL	AL359813	http://www.ebi.ac.uk/ena/data/view/AL359813
EMBL	AY032599	http://www.ebi.ac.uk/ena/data/view/AY032599
Ensembl	ENST00000244533	http://www.ensembl.org/id/ENST00000244533
Ensembl	ENST00000372530	http://www.ensembl.org/id/ENST00000372530
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0043225	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043225
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCC10	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCC10
GeneID	89845	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=89845
GeneTree	ENSGT00860000133687	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00860000133687
HGNC	HGNC:52	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:52
HOVERGEN	HBG107141	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG107141&db=HOVERGEN
HPA	HPA041607	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA041607
HPA	HPA045464	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA045464
InParanoid	Q5T3U5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q5T3U5
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR011527	http://www.ebi.ac.uk/interpro/entry/IPR011527
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
InterPro	IPR030249	http://www.ebi.ac.uk/interpro/entry/IPR030249
Jabion	89845	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=89845
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:89845	http://www.genome.jp/dbget-bin/www_bget?hsa:89845
KEGG_Orthology	KO:K05674	http://www.genome.jp/dbget-bin/www_bget?KO:K05674
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
MIM	612509	http://www.ncbi.nlm.nih.gov/omim/612509
OMA	HVAKHII	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HVAKHII
OrthoDB	EOG091G00IN	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00IN
PANTHER	PTHR24223:SF235	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24223:SF235
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PROSITE	PS50929	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929
PSORT	swissprot:MRP7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MRP7_HUMAN
PSORT-B	swissprot:MRP7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MRP7_HUMAN
PSORT2	swissprot:MRP7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MRP7_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF00664	http://pfam.xfam.org/family/PF00664
PharmGKB	PA24392	http://www.pharmgkb.org/do/serve?objId=PA24392&objCls=Gene
Phobius	swissprot:MRP7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MRP7_HUMAN
PhylomeDB	Q5T3U5	http://phylomedb.org/?seqid=Q5T3U5
ProteinModelPortal	Q5T3U5	http://www.proteinmodelportal.org/query/uniprot/Q5T3U5
PubMed	11214971	http://www.ncbi.nlm.nih.gov/pubmed/11214971
PubMed	12527806	http://www.ncbi.nlm.nih.gov/pubmed/12527806
PubMed	12566991	http://www.ncbi.nlm.nih.gov/pubmed/12566991
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	15256465	http://www.ncbi.nlm.nih.gov/pubmed/15256465
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18220336	http://www.ncbi.nlm.nih.gov/pubmed/18220336
Reactome	R-HSA-382556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-382556
RefSeq	NP_001185863	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001185863
RefSeq	NP_258261	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_258261
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	Q5T3U5	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q5T3U5
STRING	9606.ENSP00000361608	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000361608&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
SUPFAM	SSF90123	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123
TCDB	3.A.1.208.31	http://www.tcdb.org/search/result.php?tc=3.A.1.208.31
UCSC	uc003ouy	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ouy&org=rat
UniGene	Hs.55879	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.55879
UniProtKB	MRP7_HUMAN	http://www.uniprot.org/uniprot/MRP7_HUMAN
UniProtKB-AC	Q5T3U5	http://www.uniprot.org/uniprot/Q5T3U5
charge	swissprot:MRP7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MRP7_HUMAN
eggNOG	COG1132	http://eggnogapi.embl.de/nog_data/html/tree/COG1132
eggNOG	KOG0054	http://eggnogapi.embl.de/nog_data/html/tree/KOG0054
epestfind	swissprot:MRP7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MRP7_HUMAN
garnier	swissprot:MRP7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MRP7_HUMAN
helixturnhelix	swissprot:MRP7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MRP7_HUMAN
hmoment	swissprot:MRP7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MRP7_HUMAN
iep	swissprot:MRP7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MRP7_HUMAN
inforesidue	swissprot:MRP7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MRP7_HUMAN
neXtProt	NX_Q5T3U5	http://www.nextprot.org/db/entry/NX_Q5T3U5
octanol	swissprot:MRP7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MRP7_HUMAN
pepcoil	swissprot:MRP7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MRP7_HUMAN
pepdigest	swissprot:MRP7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MRP7_HUMAN
pepinfo	swissprot:MRP7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MRP7_HUMAN
pepnet	swissprot:MRP7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MRP7_HUMAN
pepstats	swissprot:MRP7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MRP7_HUMAN
pepwheel	swissprot:MRP7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MRP7_HUMAN
pepwindow	swissprot:MRP7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MRP7_HUMAN
sigcleave	swissprot:MRP7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MRP7_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CLCN3_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=ClC-3A; IsoId=P51790-1; Sequence=Displayed; Name=2; Synonyms=ClC-3B; IsoId=P51790-2; Sequence=VSP_016073; Name=3; IsoId=P51790-4; Sequence=VSP_045105; Name=4; IsoId=P51790-5; Sequence=VSP_054415; Note=No experimental confirmation available.; 
# AltName	CLCN3_HUMAN	Chloride channel protein 3
# AltName	CLCN3_HUMAN	Chloride transporter ClC-3
# BioGrid	107596	13
# CCDS	CCDS34100	-. [P51790-2]
# CCDS	CCDS34101	-. [P51790-1]
# CCDS	CCDS58932	-. [P51790-4]
# ChiTaRS	CLCN3	human
# DOMAIN	CLCN3_HUMAN	Isoform 2 contains a C-terminal PDZ-binding motif mediating the interaction with GOPC. {ECO 0000269|PubMed 11967229}. 
# Ensembl	ENST00000347613	ENSP00000261514; ENSG00000109572. [P51790-2]
# Ensembl	ENST00000360642	ENSP00000353857; ENSG00000109572. [P51790-4]
# Ensembl	ENST00000513761	ENSP00000424603; ENSG00000109572. [P51790-1]
# ExpressionAtlas	P51790	baseline and differential
# FUNCTION	CLCN3_HUMAN	Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory. {ECO 0000269|PubMed 11967229}. 
# GO_component	GO:0000139	Golgi membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005769	early endosome; IDA:UniProtKB.
# GO_component	GO:0005770	late endosome; IDA:UniProtKB.
# GO_component	GO:0005794	Golgi apparatus; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:GO_Central.
# GO_component	GO:0008021	synaptic vesicle; IDA:GO_Central.
# GO_component	GO:0009897	external side of plasma membrane; IDA:GO_Central.
# GO_component	GO:0009986	cell surface; NAS:UniProtKB.
# GO_component	GO:0012506	vesicle membrane; IDA:UniProtKB.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; TAS:UniProtKB.
# GO_component	GO:0030141	secretory granule; IDA:GO_Central.
# GO_component	GO:0030658	transport vesicle membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0031410	cytoplasmic vesicle; IDA:GO_Central.
# GO_component	GO:0031901	early endosome membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0031902	late endosome membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0042581	specific granule; IDA:GO_Central.
# GO_component	GO:0045335	phagocytic vesicle; IDA:GO_Central.
# GO_function	GO:0005247	voltage-gated chloride channel activity; TAS:ProtInc.
# GO_function	GO:0005254	chloride channel activity; TAS:UniProtKB.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0015297	antiporter activity; IEA:UniProtKB-KW.
# GO_function	GO:0030165	PDZ domain binding; IDA:UniProtKB.
# GO_function	GO:0031404	chloride ion binding; IBA:GO_Central.
# GO_function	GO:0042803	protein homodimerization activity; NAS:UniProtKB.
# GO_function	GO:0046982	protein heterodimerization activity; IDA:UniProtKB.
# GO_function	GO:0072320	volume-sensitive chloride channel activity; IMP:GO_Central.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006885	regulation of pH; TAS:UniProtKB.
# GO_process	GO:0045794	negative regulation of cell volume; IMP:GO_Central.
# GO_process	GO:0048388	endosomal lumen acidification; TAS:UniProtKB.
# GO_process	GO:1902476	chloride transmembrane transport; IDA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.10.3080.10	-; 3.
# Genevisible	P51790	HS
# HGNC	HGNC:2021	CLCN3
# IntAct	P51790	6
# InterPro	IPR000644	CBS_dom
# InterPro	IPR001807	Cl-channel_volt-gated
# InterPro	IPR002245	Cl_channel-3
# InterPro	IPR014743	Cl-channel_core
# KEGG_Brite	ko04040	Ion channels
# MIM	600580	gene
# MISCELLANEOUS	The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {ECO	0000250}. 
# Organism	CLCN3_HUMAN	Homo sapiens (Human)
# PIR	I37240	I37240
# PRINTS	PR00762	CLCHANNEL
# PRINTS	PR01114	CLCHANNEL3
# PROSITE	PS51371	CBS; 2
# PTM	CLCN3_HUMAN	N-glycosylated. {ECO 0000269|PubMed 11274166, ECO 0000269|PubMed 12471024}. 
# Pfam	PF00571	CBS; 2
# Pfam	PF00654	Voltage_CLC
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	CLCN3_HUMAN	H(+)/Cl(-) exchange transporter 3
# RefSeq	NP_001230301	NM_001243372.1. [P51790-4]
# RefSeq	NP_001230303	NM_001243374.1
# RefSeq	NP_001820	NM_001829.3. [P51790-1]
# RefSeq	NP_776297	NM_173872.3. [P51790-2]
# SEQUENCE CAUTION	Sequence=BAC54560.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA55281.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 2 CBS domains. {ECO:0000255|PROSITE- ProRule	PRU00703}. 
# SMART	SM00116	CBS; 2
# SUBCELLULAR LOCATION	CLCN3_HUMAN	Isoform 1  Early endosome membrane {ECO 0000269|PubMed 12471024}; Multi-pass membrane protein {ECO 0000255}. Late endosome membrane {ECO 0000269|PubMed 12471024}; Multi-pass membrane protein {ECO 0000255}. Cytoplasmic vesicle, secretory vesicle membrane {ECO 0000250|UniProtKB P51791}; Multi-pass membrane protein {ECO 0000255}. Note=Isoform 1 is localized mainly in late endosomes. {ECO 0000269|PubMed 12471024}. 
# SUBCELLULAR LOCATION	CLCN3_HUMAN	Isoform 2  Golgi apparatus membrane {ECO 0000269|PubMed 12471024}; Multi-pass membrane protein {ECO 0000255}. Note=Isoform 2 is mainly enriched in the Golgi. {ECO 0000269|PubMed 12471024}. 
# SUBUNIT	CLCN3_HUMAN	Homo- or heterodimer. Isoform 2 interacts with GOPC, PDZK1 and SLC9A3R1/EBP50. {ECO 0000269|PubMed 11967229, ECO 0000269|PubMed 12471024}. 
# SUPFAM	SSF81340	SSF81340; 3
# TISSUE SPECIFICITY	CLCN3_HUMAN	Expressed primarily in tissues derived from neuroectoderm. Within the brain, its expression is particularly evident in the hippocampus, olfactory cortex, and olfactory bulb. Highly expressed in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Also expressed in tracheal and alveolar epithelial cells, and intima and media of the pulmonary vessels. Expressed in bronchus and colon (at protein level). {ECO 0000269|PubMed 10198195, ECO 0000269|PubMed 11967229, ECO 0000269|PubMed 12471024}. 
# UCSC	uc003ish	human. [P51790-1]
# eggNOG	COG0038	LUCA
# eggNOG	KOG0475	Eukaryota
BLAST	swissprot:CLCN3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CLCN3_HUMAN
BioCyc	ZFISH:ENSG00000109572-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000109572-MONOMER
COXPRESdb	1182	http://coxpresdb.jp/data/gene/1182.shtml
CleanEx	HS_CLCN3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CLCN3
DOI	10.1006/geno.1995.1015	http://dx.doi.org/10.1006/geno.1995.1015
DOI	10.1006/jmcc.1998.0901	http://dx.doi.org/10.1006/jmcc.1998.0901
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M009376200	http://dx.doi.org/10.1074/jbc.M009376200
DOI	10.1074/jbc.M211050200	http://dx.doi.org/10.1074/jbc.M211050200
DOI	10.1076/ceyr.17.7.708.5162	http://dx.doi.org/10.1076/ceyr.17.7.708.5162
DOI	10.1096/fj.01-0845fje	http://dx.doi.org/10.1096/fj.01-0845fje
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AB019542	http://www.ebi.ac.uk/ena/data/view/AB019542
EMBL	AC084724	http://www.ebi.ac.uk/ena/data/view/AC084724
EMBL	AC106878	http://www.ebi.ac.uk/ena/data/view/AC106878
EMBL	AF029346	http://www.ebi.ac.uk/ena/data/view/AF029346
EMBL	AF172729	http://www.ebi.ac.uk/ena/data/view/AF172729
EMBL	AK304362	http://www.ebi.ac.uk/ena/data/view/AK304362
EMBL	BC136510	http://www.ebi.ac.uk/ena/data/view/BC136510
EMBL	BX647119	http://www.ebi.ac.uk/ena/data/view/BX647119
EMBL	CH471056	http://www.ebi.ac.uk/ena/data/view/CH471056
EMBL	CH471056	http://www.ebi.ac.uk/ena/data/view/CH471056
EMBL	X78520	http://www.ebi.ac.uk/ena/data/view/X78520
EMBL	X78520	http://www.ebi.ac.uk/ena/data/view/X78520
Ensembl	ENST00000347613	http://www.ensembl.org/id/ENST00000347613
Ensembl	ENST00000360642	http://www.ensembl.org/id/ENST00000360642
Ensembl	ENST00000513761	http://www.ensembl.org/id/ENST00000513761
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005769	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005769
GO_component	GO:0005770	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005770
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008021
GO_component	GO:0009897	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009897
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0012506	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0012506
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030141	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030141
GO_component	GO:0030658	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030658
GO_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GO_component	GO:0031901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031901
GO_component	GO:0031902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031902
GO_component	GO:0042581	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042581
GO_component	GO:0045335	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045335
GO_function	GO:0005247	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005247
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0015297	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297
GO_function	GO:0030165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030165
GO_function	GO:0031404	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031404
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_function	GO:0046982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046982
GO_function	GO:0072320	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072320
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006885	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006885
GO_process	GO:0045794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045794
GO_process	GO:0048388	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048388
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.10.3080.10	http://www.cathdb.info/version/latest/superfamily/1.10.3080.10
GeneCards	CLCN3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CLCN3
GeneID	1182	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1182
GeneTree	ENSGT00760000119109	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119109
H-InvDB	HIX0024545	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0024545
HGNC	HGNC:2021	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2021
HOGENOM	HOG000164493	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000164493&db=HOGENOM6
HPA	HPA044723	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA044723
InParanoid	P51790	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P51790
IntAct	P51790	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P51790*
InterPro	IPR000644	http://www.ebi.ac.uk/interpro/entry/IPR000644
InterPro	IPR001807	http://www.ebi.ac.uk/interpro/entry/IPR001807
InterPro	IPR002245	http://www.ebi.ac.uk/interpro/entry/IPR002245
InterPro	IPR014743	http://www.ebi.ac.uk/interpro/entry/IPR014743
Jabion	1182	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1182
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:1182	http://www.genome.jp/dbget-bin/www_bget?hsa:1182
KEGG_Orthology	KO:K05012	http://www.genome.jp/dbget-bin/www_bget?KO:K05012
MIM	600580	http://www.ncbi.nlm.nih.gov/omim/600580
MINT	MINT-1783418	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1783418
OMA	SSQLCQY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SSQLCQY
OrthoDB	EOG091G01YH	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01YH
PRINTS	PR00762	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00762
PRINTS	PR01114	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01114
PROSITE	PS51371	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51371
PSORT	swissprot:CLCN3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CLCN3_HUMAN
PSORT-B	swissprot:CLCN3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CLCN3_HUMAN
PSORT2	swissprot:CLCN3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CLCN3_HUMAN
Pfam	PF00571	http://pfam.xfam.org/family/PF00571
Pfam	PF00654	http://pfam.xfam.org/family/PF00654
PharmGKB	PA26548	http://www.pharmgkb.org/do/serve?objId=PA26548&objCls=Gene
Phobius	swissprot:CLCN3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CLCN3_HUMAN
PhylomeDB	P51790	http://phylomedb.org/?seqid=P51790
ProteinModelPortal	P51790	http://www.proteinmodelportal.org/query/uniprot/P51790
PubMed	10198195	http://www.ncbi.nlm.nih.gov/pubmed/10198195
PubMed	11274166	http://www.ncbi.nlm.nih.gov/pubmed/11274166
PubMed	11967229	http://www.ncbi.nlm.nih.gov/pubmed/11967229
PubMed	12471024	http://www.ncbi.nlm.nih.gov/pubmed/12471024
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	7665160	http://www.ncbi.nlm.nih.gov/pubmed/7665160
PubMed	9678416	http://www.ncbi.nlm.nih.gov/pubmed/9678416
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_001230301	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001230301
RefSeq	NP_001230303	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001230303
RefSeq	NP_001820	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001820
RefSeq	NP_776297	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_776297
SMART	SM00116	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00116
SMR	P51790	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P51790
STRING	9606.ENSP00000261514	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000261514&targetmode=cogs
SUPFAM	SSF81340	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81340
UCSC	uc003ish	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ish&org=rat
UniGene	Hs.481186	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.481186
UniGene	Hs.736017	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.736017
UniProtKB	CLCN3_HUMAN	http://www.uniprot.org/uniprot/CLCN3_HUMAN
UniProtKB-AC	P51790	http://www.uniprot.org/uniprot/P51790
charge	swissprot:CLCN3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CLCN3_HUMAN
eggNOG	COG0038	http://eggnogapi.embl.de/nog_data/html/tree/COG0038
eggNOG	KOG0475	http://eggnogapi.embl.de/nog_data/html/tree/KOG0475
epestfind	swissprot:CLCN3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CLCN3_HUMAN
garnier	swissprot:CLCN3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CLCN3_HUMAN
helixturnhelix	swissprot:CLCN3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLCN3_HUMAN
hmoment	swissprot:CLCN3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CLCN3_HUMAN
iep	swissprot:CLCN3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CLCN3_HUMAN
inforesidue	swissprot:CLCN3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CLCN3_HUMAN
neXtProt	NX_P51790	http://www.nextprot.org/db/entry/NX_P51790
octanol	swissprot:CLCN3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CLCN3_HUMAN
pepcoil	swissprot:CLCN3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CLCN3_HUMAN
pepdigest	swissprot:CLCN3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CLCN3_HUMAN
pepinfo	swissprot:CLCN3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CLCN3_HUMAN
pepnet	swissprot:CLCN3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CLCN3_HUMAN
pepstats	swissprot:CLCN3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CLCN3_HUMAN
pepwheel	swissprot:CLCN3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CLCN3_HUMAN
pepwindow	swissprot:CLCN3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CLCN3_HUMAN
sigcleave	swissprot:CLCN3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CLCN3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GTR6_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UGQ3-1; Sequence=Displayed; Name=2; IsoId=Q9UGQ3-2; Sequence=VSP_041402; 
# AltName	GTR6_HUMAN	Glucose transporter type 6
# AltName	GTR6_HUMAN	Glucose transporter type 9
# BioGrid	116352	3
# CAUTION	Has been described as GLUT9 in literature, but this gene name has already been used for SLC2A9. {ECO	0000305}.
# CCDS	CCDS48052	-. [Q9UGQ3-2]
# CCDS	CCDS6975	-. [Q9UGQ3-1]
# CDD	cd06174	MFS
# ChiTaRS	SLC2A6	human
# Ensembl	ENST00000371897	ENSP00000360964; ENSG00000160326. [Q9UGQ3-2]
# Ensembl	ENST00000371899	ENSP00000360966; ENSG00000160326. [Q9UGQ3-1]
# Ensembl	ENST00000625425	ENSP00000486637; ENSG00000281165. [Q9UGQ3-2]
# Ensembl	ENST00000626271	ENSP00000487067; ENSG00000281165. [Q9UGQ3-1]
# ExpressionAtlas	Q9UGQ3	baseline and differential
# FUNCTION	GTR6_HUMAN	Facilitative glucose transporter; binds cytochalasin B with low affinity. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016020	membrane; NAS:UniProtKB.
# GO_function	GO:0005355	glucose transmembrane transporter activity; NAS:UniProtKB.
# GO_function	GO:0055056	D-glucose transmembrane transporter activity; TAS:Reactome.
# GO_function	GTR6_HUMAN	GO 0005351 sugar proton symporter activity; IBA GO_Central.
# GO_process	GO:0046323	glucose import; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q9UGQ3	HS
# HGNC	HGNC:11011	SLC2A6
# InterPro	IPR003663	Sugar/inositol_transpt
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR005829	Sugar_transporter_CS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	606813	gene
# Organism	GTR6_HUMAN	Homo sapiens (Human)
# PRINTS	PR00171	SUGRTRNSPORT
# PROSITE	PS00216	SUGAR_TRANSPORT_1
# PROSITE	PS00217	SUGAR_TRANSPORT_2
# PROSITE	PS50850	MFS
# Pfam	PF00083	Sugar_tr
# Proteomes	UP000005640	Chromosome 9
# Reactome	R-HSA-428790	Facilitative Na+-independent glucose transporters
# RecName	GTR6_HUMAN	Solute carrier family 2, facilitated glucose transporter member 6
# RefSeq	NP_001138571	NM_001145099.1. [Q9UGQ3-2]
# RefSeq	NP_060055	NM_017585.3. [Q9UGQ3-1]
# SIMILARITY	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	GTR6_HUMAN	Cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Note=The dileucine internalization motif is critical for intracellular sequestration. {ECO 0000250}. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.1.1.88	the major facilitator superfamily (mfs)
# TIGRFAMs	TIGR00879	SP
# TISSUE SPECIFICITY	GTR6_HUMAN	Highly expressed in brain, spleen and peripheral blood leukocytes. 
# UCSC	uc004cee	human. [Q9UGQ3-1]
# eggNOG	ENOG410XNQK	LUCA
# eggNOG	KOG0254	Eukaryota
BLAST	swissprot:GTR6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GTR6_HUMAN
BioCyc	ZFISH:ENSG00000160326-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000160326-MONOMER
COXPRESdb	11182	http://coxpresdb.jp/data/gene/11182.shtml
CleanEx	HS_SLC2A6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC2A6
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/bj3500771	http://dx.doi.org/10.1042/bj3500771
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1093/dnares/12.2.117	http://dx.doi.org/10.1093/dnares/12.2.117
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AJ011372	http://www.ebi.ac.uk/ena/data/view/AJ011372
EMBL	AK074836	http://www.ebi.ac.uk/ena/data/view/AK074836
EMBL	AK074927	http://www.ebi.ac.uk/ena/data/view/AK074927
EMBL	AK222919	http://www.ebi.ac.uk/ena/data/view/AK222919
EMBL	AL593848	http://www.ebi.ac.uk/ena/data/view/AL593848
EMBL	BC013740	http://www.ebi.ac.uk/ena/data/view/BC013740
EMBL	CH471090	http://www.ebi.ac.uk/ena/data/view/CH471090
EMBL	CH471090	http://www.ebi.ac.uk/ena/data/view/CH471090
EMBL	Y17803	http://www.ebi.ac.uk/ena/data/view/Y17803
Ensembl	ENST00000371897	http://www.ensembl.org/id/ENST00000371897
Ensembl	ENST00000371899	http://www.ensembl.org/id/ENST00000371899
Ensembl	ENST00000625425	http://www.ensembl.org/id/ENST00000625425
Ensembl	ENST00000626271	http://www.ensembl.org/id/ENST00000626271
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0005351	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005351
GO_function	GO:0005355	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005355
GO_function	GO:0055056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055056
GO_process	GO:0046323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046323
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC2A6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC2A6
GeneID	11182	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11182
GeneTree	ENSGT00850000132274	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00850000132274
H-InvDB	HIX0008509	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0008509
HGNC	HGNC:11011	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11011
HOGENOM	HOG000202868	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202868&db=HOGENOM6
HOVERGEN	HBG104335	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG104335&db=HOVERGEN
HPA	CAB017800	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB017800
HPA	CAB046014	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB046014
HPA	HPA042272	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042272
InParanoid	Q9UGQ3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UGQ3
InterPro	IPR003663	http://www.ebi.ac.uk/interpro/entry/IPR003663
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR005829	http://www.ebi.ac.uk/interpro/entry/IPR005829
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	11182	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=11182
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:11182	http://www.genome.jp/dbget-bin/www_bget?hsa:11182
KEGG_Orthology	KO:K08144	http://www.genome.jp/dbget-bin/www_bget?KO:K08144
MIM	606813	http://www.ncbi.nlm.nih.gov/omim/606813
OMA	KSQASWF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KSQASWF
OrthoDB	EOG091G1600	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G1600
PRINTS	PR00171	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00171
PROSITE	PS00216	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00216
PROSITE	PS00217	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00217
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:GTR6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GTR6_HUMAN
PSORT-B	swissprot:GTR6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GTR6_HUMAN
PSORT2	swissprot:GTR6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GTR6_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
PharmGKB	PA35881	http://www.pharmgkb.org/do/serve?objId=PA35881&objCls=Gene
Phobius	swissprot:GTR6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GTR6_HUMAN
PhylomeDB	Q9UGQ3	http://phylomedb.org/?seqid=Q9UGQ3
ProteinModelPortal	Q9UGQ3	http://www.proteinmodelportal.org/query/uniprot/Q9UGQ3
PubMed	10970791	http://www.ncbi.nlm.nih.gov/pubmed/10970791
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16303743	http://www.ncbi.nlm.nih.gov/pubmed/16303743
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
Reactome	R-HSA-428790	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428790
RefSeq	NP_001138571	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001138571
RefSeq	NP_060055	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060055
STRING	9606.ENSP00000360966	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000360966&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.1.88	http://www.tcdb.org/search/result.php?tc=2.A.1.1.88
TIGRFAMs	TIGR00879	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00879
UCSC	uc004cee	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004cee&org=rat
UniGene	Hs.244378	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.244378
UniProtKB	GTR6_HUMAN	http://www.uniprot.org/uniprot/GTR6_HUMAN
UniProtKB-AC	Q9UGQ3	http://www.uniprot.org/uniprot/Q9UGQ3
charge	swissprot:GTR6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GTR6_HUMAN
eggNOG	ENOG410XNQK	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNQK
eggNOG	KOG0254	http://eggnogapi.embl.de/nog_data/html/tree/KOG0254
epestfind	swissprot:GTR6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GTR6_HUMAN
garnier	swissprot:GTR6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GTR6_HUMAN
helixturnhelix	swissprot:GTR6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GTR6_HUMAN
hmoment	swissprot:GTR6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GTR6_HUMAN
iep	swissprot:GTR6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GTR6_HUMAN
inforesidue	swissprot:GTR6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GTR6_HUMAN
neXtProt	NX_Q9UGQ3	http://www.nextprot.org/db/entry/NX_Q9UGQ3
octanol	swissprot:GTR6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GTR6_HUMAN
pepcoil	swissprot:GTR6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GTR6_HUMAN
pepdigest	swissprot:GTR6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GTR6_HUMAN
pepinfo	swissprot:GTR6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GTR6_HUMAN
pepnet	swissprot:GTR6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GTR6_HUMAN
pepstats	swissprot:GTR6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GTR6_HUMAN
pepwheel	swissprot:GTR6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GTR6_HUMAN
pepwindow	swissprot:GTR6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GTR6_HUMAN
sigcleave	swissprot:GTR6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GTR6_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNF1_HUMAN	Voltage-gated potassium channel subunit Kv5.1
# AltName	KCNF1_HUMAN	kH1
# BioGrid	109956	4
# DOMAIN	KCNF1_HUMAN	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. 
# Ensembl	ENST00000295082	ENSP00000295082; ENSG00000162975
# FUNCTION	KCNF1_HUMAN	Putative voltage-gated potassium channel. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IEA:InterPro.
# GO_component	GO:0016021	integral component of membrane; IBA:GO_Central.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; IBA:GO_Central.
# GO_function	GO:0005267	potassium channel activity; TAS:ProtInc.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0051260	protein homooligomerization; IEA:InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# Gene3D	1.20.120.350	-; 1.
# Genevisible	Q9H3M0	HS
# HGNC	HGNC:6246	KCNF1
# InterPro	IPR003131	T1-type_BTB
# InterPro	IPR003968	K_chnl_volt-dep_Kv
# InterPro	IPR003971	K_chnl_volt-dep_Kv9
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR011333	SKP1/BTB/POZ
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko04040	Ion channels
# MIM	603787	gene
# Organism	KCNF1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11537	PTHR11537
# PIR	JC5919	JC5919
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01491	KVCHANNEL
# PRINTS	PR01494	KV9CHANNEL
# Pfam	PF00520	Ion_trans
# Pfam	PF02214	BTB_2
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# RecName	KCNF1_HUMAN	Potassium voltage-gated channel subfamily F member 1
# RefSeq	NP_002227	NM_002236.4
# SIMILARITY	Belongs to the potassium channel family. F (TC 1.A.1.2) subfamily. Kv5.1/KCNF1 sub-subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCNF1_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Heteromultimer with KCNG3, KCNG4 and KCNV2. Interacts with DLG1. {ECO:0000269|PubMed	12445884}. 
# SUPFAM	SSF54695	SSF54695
# TCDB	1.A.1.2.18	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	KCNF1_HUMAN	Detected in heart, brain, liver, skeletal muscle, kidney and pancreas. 
# UCSC	uc002rax	human
# eggNOG	COG1226	LUCA
# eggNOG	KOG3713	Eukaryota
BLAST	swissprot:KCNF1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNF1_HUMAN
BioCyc	ZFISH:ENSG00000162975-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000162975-MONOMER
COXPRESdb	3754	http://coxpresdb.jp/data/gene/3754.shtml
CleanEx	HS_KCNF1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNF1
DOI	10.1006/bbrc.1997.7830	http://dx.doi.org/10.1006/bbrc.1997.7830
DOI	10.1016/S0008-6363(02)00602-8	http://dx.doi.org/10.1016/S0008-6363(02)00602-8
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC019041	http://www.ebi.ac.uk/ena/data/view/AC019041
EMBL	AF029780	http://www.ebi.ac.uk/ena/data/view/AF029780
EMBL	AF033382	http://www.ebi.ac.uk/ena/data/view/AF033382
EMBL	BC026110	http://www.ebi.ac.uk/ena/data/view/BC026110
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
Ensembl	ENST00000295082	http://www.ensembl.org/id/ENST00000295082
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	KCNF1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNF1
GeneID	3754	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3754
GeneTree	ENSGT00760000118981	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118981
HGNC	HGNC:6246	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6246
HOGENOM	HOG000231016	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231016&db=HOGENOM6
HOVERGEN	HBG052230	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052230&db=HOVERGEN
HPA	CAB004678	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB004678
HPA	HPA014738	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014738
InParanoid	Q9H3M0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9H3M0
IntAct	Q9H3M0	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9H3M0*
InterPro	IPR003131	http://www.ebi.ac.uk/interpro/entry/IPR003131
InterPro	IPR003968	http://www.ebi.ac.uk/interpro/entry/IPR003968
InterPro	IPR003971	http://www.ebi.ac.uk/interpro/entry/IPR003971
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR011333	http://www.ebi.ac.uk/interpro/entry/IPR011333
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	3754	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3754
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3754	http://www.genome.jp/dbget-bin/www_bget?hsa:3754
KEGG_Orthology	KO:K04899	http://www.genome.jp/dbget-bin/www_bget?KO:K04899
MIM	603787	http://www.ncbi.nlm.nih.gov/omim/603787
OMA	NEMEFWK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NEMEFWK
OrthoDB	EOG091G0FP3	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0FP3
PANTHER	PTHR11537	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01491	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01491
PRINTS	PR01494	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01494
PSORT	swissprot:KCNF1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNF1_HUMAN
PSORT-B	swissprot:KCNF1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNF1_HUMAN
PSORT2	swissprot:KCNF1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNF1_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF02214	http://pfam.xfam.org/family/PF02214
PharmGKB	PA30033	http://www.pharmgkb.org/do/serve?objId=PA30033&objCls=Gene
Phobius	swissprot:KCNF1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNF1_HUMAN
PhylomeDB	Q9H3M0	http://phylomedb.org/?seqid=Q9H3M0
ProteinModelPortal	Q9H3M0	http://www.proteinmodelportal.org/query/uniprot/Q9H3M0
PubMed	12445884	http://www.ncbi.nlm.nih.gov/pubmed/12445884
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	9434767	http://www.ncbi.nlm.nih.gov/pubmed/9434767
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
RefSeq	NP_002227	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002227
SMR	Q9H3M0	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9H3M0
STRING	9606.ENSP00000295082	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000295082&targetmode=cogs
SUPFAM	SSF54695	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54695
TCDB	1.A.1.2.18	http://www.tcdb.org/search/result.php?tc=1.A.1.2.18
UCSC	uc002rax	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002rax&org=rat
UniGene	Hs.23735	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.23735
UniProtKB	KCNF1_HUMAN	http://www.uniprot.org/uniprot/KCNF1_HUMAN
UniProtKB-AC	Q9H3M0	http://www.uniprot.org/uniprot/Q9H3M0
charge	swissprot:KCNF1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNF1_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG3713	http://eggnogapi.embl.de/nog_data/html/tree/KOG3713
epestfind	swissprot:KCNF1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNF1_HUMAN
garnier	swissprot:KCNF1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNF1_HUMAN
helixturnhelix	swissprot:KCNF1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNF1_HUMAN
hmoment	swissprot:KCNF1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNF1_HUMAN
iep	swissprot:KCNF1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNF1_HUMAN
inforesidue	swissprot:KCNF1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNF1_HUMAN
neXtProt	NX_Q9H3M0	http://www.nextprot.org/db/entry/NX_Q9H3M0
octanol	swissprot:KCNF1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNF1_HUMAN
pepcoil	swissprot:KCNF1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNF1_HUMAN
pepdigest	swissprot:KCNF1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNF1_HUMAN
pepinfo	swissprot:KCNF1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNF1_HUMAN
pepnet	swissprot:KCNF1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNF1_HUMAN
pepstats	swissprot:KCNF1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNF1_HUMAN
pepwheel	swissprot:KCNF1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNF1_HUMAN
pepwindow	swissprot:KCNF1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNF1_HUMAN
sigcleave	swissprot:KCNF1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNF1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CLCKA_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P51800-1; Sequence=Displayed; Name=2; IsoId=P51800-2; Sequence=VSP_044700; Note=No experimental confirmation available.; Name=3; IsoId=P51800-3; Sequence=VSP_045795; Note=No experimental confirmation available.; 
# AltName	CLCKA_HUMAN	ClC-K1
# CCDS	CCDS167	-. [P51800-1]
# CCDS	CCDS41269	-. [P51800-3]
# CCDS	CCDS57973	-. [P51800-2]
# DISEASE	CLCKA_HUMAN	Bartter syndrome 4B, neonatal, with sensorineural deafness (BARTS4B) [MIM 613090]  A digenic form of Bartter syndrome, an autosomal recessive disorder characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BARTS4B is associated with sensorineural deafness. {ECO 0000269|PubMed 15044642, ECO 0000269|PubMed 18310267}. Note=The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Loss-of-function of both CLCNKA and CLCNKB results in the disease phenotype (PubMed 18310267). {ECO 0000269|PubMed 18310267}. 
# DrugBank	DB04552	Niflumic Acid
# ENZYME REGULATION	Activated by extracellular calcium and inhibited by extracellular protons. {ECO:0000305|PubMed	23148261}. 
# Ensembl	ENST00000331433	ENSP00000332771; ENSG00000186510. [P51800-1]
# Ensembl	ENST00000375692	ENSP00000364844; ENSG00000186510. [P51800-3]
# Ensembl	ENST00000439316	ENSP00000414445; ENSG00000186510. [P51800-2]
# FUNCTION	CLCKA_HUMAN	Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_function	GO:0005247	voltage-gated chloride channel activity; TAS:Reactome.
# GO_function	GO:0031404	chloride ion binding; IBA:GO_Central.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007588	excretion; TAS:ProtInc.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:1902476	chloride transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.10.3080.10	-; 2.
# Genevisible	P51800	HS
# HGNC	HGNC:2026	CLCNKA
# IntAct	P51800	9
# InterPro	IPR000644	CBS_dom
# InterPro	IPR001807	Cl-channel_volt-gated
# InterPro	IPR002250	Cl_channel-K
# InterPro	IPR014743	Cl-channel_core
# KEGG_Brite	ko04040	Ion channels
# KEGG_Disease	H00239	[Endocrine disease; Urinary system disease] Bartter syndrome
# MIM	602024	gene
# MIM	613090	phenotype
# Organism	CLCKA_HUMAN	Homo sapiens (Human)
# Orphanet	89938	Infantile Bartter syndrome with sensorineural deafness
# PDB	2PFI	X-ray; 1.60 A; A/B=533-687
# PIR	C57713	C57713
# PRINTS	PR00762	CLCHANNEL
# PRINTS	PR01119	CLCHANNELKDY
# PROSITE	PS51371	CBS; 2
# Pfam	PF00571	CBS
# Pfam	PF00654	Voltage_CLC
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	CLCKA_HUMAN	Chloride channel protein ClC-Ka
# RefSeq	NP_001036169	NM_001042704.1. [P51800-3]
# RefSeq	NP_001244068	NM_001257139.1. [P51800-2]
# RefSeq	NP_004061	NM_004070.3. [P51800-1]
# SIMILARITY	Belongs to the chloride channel (TC 2.A.49) family. CLCNKA subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 2 CBS domains. {ECO:0000255|PROSITE- ProRule	PRU00703}.
# SMART	SM00116	CBS
# SUBCELLULAR LOCATION	CLCKA_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	CLCKA_HUMAN	Homodimer (PubMed 17562318). Interacts with BSND. Forms heteromers with BSND in the thin ascending limb of Henle (By similarity). {ECO 0000250|UniProtKB Q9WUB7, ECO 0000269|PubMed 17562318}. 
# SUPFAM	SSF81340	SSF81340; 2
# TISSUE SPECIFICITY	Expressed predominantly in the kidney. All nephron segments expressing BSND also express CLCNK proteins. {ECO:0000269|PubMed	11734858}. 
# UCSC	uc001axu	human. [P51800-1]
# eggNOG	COG0038	LUCA
# eggNOG	KOG0476	Eukaryota
BLAST	swissprot:CLCKA_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CLCKA_HUMAN
BioCyc	ZFISH:G66-31526-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31526-MONOMER
COXPRESdb	1187	http://coxpresdb.jp/data/gene/1187.shtml
CleanEx	HS_CLCNKA	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CLCNKA
DIP	DIP-29432N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29432N
DOI	10.1016/j.str.2007.04.013	http://dx.doi.org/10.1016/j.str.2007.04.013
DOI	10.1038/35107099	http://dx.doi.org/10.1038/35107099
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1056/NEJMoa032843	http://dx.doi.org/10.1056/NEJMoa032843
DOI	10.1073/pnas.91.15.6943	http://dx.doi.org/10.1073/pnas.91.15.6943
DOI	10.1085/jgp.201210878	http://dx.doi.org/10.1085/jgp.201210878
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1136/jmg.2007.052944	http://dx.doi.org/10.1136/jmg.2007.052944
DrugBank	DB04552	http://www.drugbank.ca/drugs/DB04552
EMBL	AK225550	http://www.ebi.ac.uk/ena/data/view/AK225550
EMBL	AK298285	http://www.ebi.ac.uk/ena/data/view/AK298285
EMBL	AL355994	http://www.ebi.ac.uk/ena/data/view/AL355994
EMBL	AL355994	http://www.ebi.ac.uk/ena/data/view/AL355994
EMBL	BC048282	http://www.ebi.ac.uk/ena/data/view/BC048282
EMBL	BC053869	http://www.ebi.ac.uk/ena/data/view/BC053869
EMBL	U93878	http://www.ebi.ac.uk/ena/data/view/U93878
EMBL	Z30643	http://www.ebi.ac.uk/ena/data/view/Z30643
Ensembl	ENST00000331433	http://www.ensembl.org/id/ENST00000331433
Ensembl	ENST00000375692	http://www.ensembl.org/id/ENST00000375692
Ensembl	ENST00000439316	http://www.ensembl.org/id/ENST00000439316
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_function	GO:0005247	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005247
GO_function	GO:0031404	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031404
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007588
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.10.3080.10	http://www.cathdb.info/version/latest/superfamily/1.10.3080.10
GeneCards	CLCNKA	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CLCNKA
GeneID	1187	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1187
GeneTree	ENSGT00760000119109	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119109
HGNC	HGNC:2026	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2026
HOGENOM	HOG000231297	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231297&db=HOGENOM6
HOVERGEN	HBG005332	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG005332&db=HOVERGEN
HPA	HPA057717	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA057717
InParanoid	P51800	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P51800
IntAct	P51800	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P51800*
InterPro	IPR000644	http://www.ebi.ac.uk/interpro/entry/IPR000644
InterPro	IPR001807	http://www.ebi.ac.uk/interpro/entry/IPR001807
InterPro	IPR002250	http://www.ebi.ac.uk/interpro/entry/IPR002250
InterPro	IPR014743	http://www.ebi.ac.uk/interpro/entry/IPR014743
Jabion	1187	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1187
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00239	http://www.genome.jp/dbget-bin/www_bget?H00239
KEGG_Gene	hsa:1187	http://www.genome.jp/dbget-bin/www_bget?hsa:1187
KEGG_Orthology	KO:K05017	http://www.genome.jp/dbget-bin/www_bget?KO:K05017
MIM	602024	http://www.ncbi.nlm.nih.gov/omim/602024
MIM	613090	http://www.ncbi.nlm.nih.gov/omim/613090
OMA	PCPHIRR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PCPHIRR
Orphanet	89938	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=89938
OrthoDB	EOG091G01RJ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01RJ
PDB	2PFI	http://www.ebi.ac.uk/pdbe-srv/view/entry/2PFI
PDBsum	2PFI	http://www.ebi.ac.uk/pdbsum/2PFI
PRINTS	PR00762	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00762
PRINTS	PR01119	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01119
PROSITE	PS51371	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51371
PSORT	swissprot:CLCKA_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CLCKA_HUMAN
PSORT-B	swissprot:CLCKA_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CLCKA_HUMAN
PSORT2	swissprot:CLCKA_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CLCKA_HUMAN
Pfam	PF00571	http://pfam.xfam.org/family/PF00571
Pfam	PF00654	http://pfam.xfam.org/family/PF00654
PharmGKB	PA26553	http://www.pharmgkb.org/do/serve?objId=PA26553&objCls=Gene
Phobius	swissprot:CLCKA_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CLCKA_HUMAN
PhylomeDB	P51800	http://phylomedb.org/?seqid=P51800
ProteinModelPortal	P51800	http://www.proteinmodelportal.org/query/uniprot/P51800
PubMed	11734858	http://www.ncbi.nlm.nih.gov/pubmed/11734858
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15044642	http://www.ncbi.nlm.nih.gov/pubmed/15044642
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17562318	http://www.ncbi.nlm.nih.gov/pubmed/17562318
PubMed	18310267	http://www.ncbi.nlm.nih.gov/pubmed/18310267
PubMed	23148261	http://www.ncbi.nlm.nih.gov/pubmed/23148261
PubMed	8041726	http://www.ncbi.nlm.nih.gov/pubmed/8041726
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_001036169	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001036169
RefSeq	NP_001244068	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001244068
RefSeq	NP_004061	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004061
SMART	SM00116	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00116
SMR	P51800	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P51800
STRING	9606.ENSP00000332771	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000332771&targetmode=cogs
SUPFAM	SSF81340	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81340
UCSC	uc001axu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001axu&org=rat
UniGene	Hs.591533	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.591533
UniProtKB	CLCKA_HUMAN	http://www.uniprot.org/uniprot/CLCKA_HUMAN
UniProtKB-AC	P51800	http://www.uniprot.org/uniprot/P51800
charge	swissprot:CLCKA_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CLCKA_HUMAN
eggNOG	COG0038	http://eggnogapi.embl.de/nog_data/html/tree/COG0038
eggNOG	KOG0476	http://eggnogapi.embl.de/nog_data/html/tree/KOG0476
epestfind	swissprot:CLCKA_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CLCKA_HUMAN
garnier	swissprot:CLCKA_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CLCKA_HUMAN
helixturnhelix	swissprot:CLCKA_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLCKA_HUMAN
hmoment	swissprot:CLCKA_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CLCKA_HUMAN
iep	swissprot:CLCKA_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CLCKA_HUMAN
inforesidue	swissprot:CLCKA_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CLCKA_HUMAN
neXtProt	NX_P51800	http://www.nextprot.org/db/entry/NX_P51800
octanol	swissprot:CLCKA_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CLCKA_HUMAN
pepcoil	swissprot:CLCKA_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CLCKA_HUMAN
pepdigest	swissprot:CLCKA_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CLCKA_HUMAN
pepinfo	swissprot:CLCKA_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CLCKA_HUMAN
pepnet	swissprot:CLCKA_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CLCKA_HUMAN
pepstats	swissprot:CLCKA_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CLCKA_HUMAN
pepwheel	swissprot:CLCKA_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CLCKA_HUMAN
pepwindow	swissprot:CLCKA_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CLCKA_HUMAN
sigcleave	swissprot:CLCKA_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CLCKA_HUMAN
## Database	ID	URL or Descriptions
# AltName	CTSR3_HUMAN	Ca(v)-like protein
# AltName	CTSR3_HUMAN	One-repeat calcium channel-like protein
# ENZYME REGULATION	CTSR3_HUMAN	The CatSper calcium channel is indirectly activated by extracellular progesterone and prostaglandins following the sequence  progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2 (PubMed 21412338, PubMed 21412339, PubMed 26989199). The CatSper calcium channel is directly inhibited by endocannabinoid 2-arachidonoylglycerol (2AG) (PubMed 26989199). Indirect activation by progesterone takes place via the following mechanism  progesterone binds and activates the acylglycerol lipase ABHD2, which in turn mediates hydrolysis of 2AG inhibitor, relieving inhibition of the CatSper channel (PubMed 26989199). The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers (PubMed 21412338, PubMed 21412339). Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH (PubMed 21412338, PubMed 21412339). {ECO 0000269|PubMed 21412338, ECO 0000269|PubMed 21412339, ECO 0000269|PubMed 26989199}. 
# Ensembl	ENST00000282611	ENSP00000282611; ENSG00000152705
# FUNCTION	CTSR3_HUMAN	Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. {ECO 0000269|PubMed 21412338, ECO 0000269|PubMed 21412339}. 
# GO_component	GO:0001669	acrosomal vesicle; IEA:Ensembl.
# GO_component	GO:0005783	endoplasmic reticulum; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0031514	motile cilium; IEA:UniProtKB-KW.
# GO_component	GO:0036128	CatSper complex; ISS:UniProtKB.
# GO_function	GO:0005245	voltage-gated calcium channel activity; IEA:Ensembl.
# GO_function	GO:0005261	cation channel activity; IBA:GO_Central.
# GO_process	GO:0006814	sodium ion transport; IEA:Ensembl.
# GO_process	GO:0006816	calcium ion transport; IBA:GO_Central.
# GO_process	GO:0007275	multicellular organism development; IEA:UniProtKB-KW.
# GO_process	GO:0030317	flagellated sperm motility; IEA:Ensembl.
# GO_process	GO:0032570	response to progesterone; TAS:Reactome.
# GO_process	GO:0034220	ion transmembrane transport; IBA:GO_Central.
# GO_process	GO:0035036	sperm-egg recognition; TAS:Reactome.
# GO_process	GO:0048240	sperm capacitation; IEA:Ensembl.
# GO_process	GO:0086010	membrane depolarization during action potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0005929	cilium
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0021700	developmental maturation
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0048870	cell motility
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q86XQ3	HS
# HGNC	HGNC:20819	CATSPER3
# InterPro	IPR005821	Ion_trans_dom
# MIM	609120	gene
# Organism	CTSR3_HUMAN	Homo sapiens (Human)
# Pfam	PF00520	Ion_trans
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-1300642	Sperm Motility And Taxes
# RecName	CTSR3_HUMAN	Cation channel sperm-associated protein 3
# RefSeq	NP_821138	NM_178019.2
# SIMILARITY	Belongs to the cation channel sperm-associated (TC 1.A.1.19) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	CTSR3_HUMAN	Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of sperm tail. 
# SUBUNIT	Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Component of the CatSper complex. Interacts with CATSPER1 (By similarity). {ECO:0000250, ECO	0000305}. 
# TCDB	1.A.1.19	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	CTSR3_HUMAN	Testis-specific. {ECO 0000269|PubMed 12646162, ECO 0000269|PubMed 12932298, ECO 0000269|PubMed 17347248}. 
# UCSC	uc003lag	human
# eggNOG	ENOG410IF9A	Eukaryota
# eggNOG	ENOG4111SVN	LUCA
BLAST	swissprot:CTSR3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CTSR3_HUMAN
COXPRESdb	347732	http://coxpresdb.jp/data/gene/347732.shtml
CleanEx	HS_CATSPER3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CATSPER3
DOI	10.1016/S0006-291X(03)00276-6	http://dx.doi.org/10.1016/S0006-291X(03)00276-6
DOI	10.1038/nature09767	http://dx.doi.org/10.1038/nature09767
DOI	10.1038/nature09769	http://dx.doi.org/10.1038/nature09769
DOI	10.1093/molehr/gam009	http://dx.doi.org/10.1093/molehr/gam009
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.aad6887	http://dx.doi.org/10.1126/science.aad6887
DOI	10.1186/1477-7827-1-53	http://dx.doi.org/10.1186/1477-7827-1-53
EMBL	AF432876	http://www.ebi.ac.uk/ena/data/view/AF432876
EMBL	AY156951	http://www.ebi.ac.uk/ena/data/view/AY156951
EMBL	BC101692	http://www.ebi.ac.uk/ena/data/view/BC101692
EMBL	BC110384	http://www.ebi.ac.uk/ena/data/view/BC110384
EMBL	BN000272	http://www.ebi.ac.uk/ena/data/view/BN000272
Ensembl	ENST00000282611	http://www.ensembl.org/id/ENST00000282611
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0001669	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001669
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0031514	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031514
GO_component	GO:0036128	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036128
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0005261	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005261
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0007275	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007275
GO_process	GO:0030317	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030317
GO_process	GO:0032570	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032570
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0035036	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035036
GO_process	GO:0048240	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048240
GO_process	GO:0086010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086010
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0005929	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005929
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0021700	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021700
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	CATSPER3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CATSPER3
GeneID	347732	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=347732
GeneTree	ENSGT00760000119325	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119325
HGNC	HGNC:20819	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20819
HOGENOM	HOG000112052	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000112052&db=HOGENOM6
HOVERGEN	HBG099875	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG099875&db=HOVERGEN
InParanoid	Q86XQ3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q86XQ3
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
Jabion	347732	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=347732
KEGG_Gene	hsa:347732	http://www.genome.jp/dbget-bin/www_bget?hsa:347732
MIM	609120	http://www.ncbi.nlm.nih.gov/omim/609120
OMA	YWKDGYN	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YWKDGYN
OrthoDB	EOG091G0D3H	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0D3H
PSORT	swissprot:CTSR3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CTSR3_HUMAN
PSORT-B	swissprot:CTSR3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CTSR3_HUMAN
PSORT2	swissprot:CTSR3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CTSR3_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
PharmGKB	PA134911185	http://www.pharmgkb.org/do/serve?objId=PA134911185&objCls=Gene
Phobius	swissprot:CTSR3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CTSR3_HUMAN
PhylomeDB	Q86XQ3	http://phylomedb.org/?seqid=Q86XQ3
ProteinModelPortal	Q86XQ3	http://www.proteinmodelportal.org/query/uniprot/Q86XQ3
PubMed	12646162	http://www.ncbi.nlm.nih.gov/pubmed/12646162
PubMed	12932298	http://www.ncbi.nlm.nih.gov/pubmed/12932298
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17347248	http://www.ncbi.nlm.nih.gov/pubmed/17347248
PubMed	21412338	http://www.ncbi.nlm.nih.gov/pubmed/21412338
PubMed	21412339	http://www.ncbi.nlm.nih.gov/pubmed/21412339
PubMed	26989199	http://www.ncbi.nlm.nih.gov/pubmed/26989199
Reactome	R-HSA-1300642	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1300642
RefSeq	NP_821138	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_821138
STRING	9606.ENSP00000282611	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000282611&targetmode=cogs
TCDB	1.A.1.19	http://www.tcdb.org/search/result.php?tc=1.A.1.19
UCSC	uc003lag	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003lag&org=rat
UniGene	Hs.631804	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.631804
UniProtKB	CTSR3_HUMAN	http://www.uniprot.org/uniprot/CTSR3_HUMAN
UniProtKB-AC	Q86XQ3	http://www.uniprot.org/uniprot/Q86XQ3
charge	swissprot:CTSR3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CTSR3_HUMAN
eggNOG	ENOG410IF9A	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IF9A
eggNOG	ENOG4111SVN	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111SVN
epestfind	swissprot:CTSR3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CTSR3_HUMAN
garnier	swissprot:CTSR3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CTSR3_HUMAN
helixturnhelix	swissprot:CTSR3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CTSR3_HUMAN
hmoment	swissprot:CTSR3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CTSR3_HUMAN
iep	swissprot:CTSR3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CTSR3_HUMAN
inforesidue	swissprot:CTSR3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CTSR3_HUMAN
neXtProt	NX_Q86XQ3	http://www.nextprot.org/db/entry/NX_Q86XQ3
octanol	swissprot:CTSR3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CTSR3_HUMAN
pepcoil	swissprot:CTSR3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CTSR3_HUMAN
pepdigest	swissprot:CTSR3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CTSR3_HUMAN
pepinfo	swissprot:CTSR3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CTSR3_HUMAN
pepnet	swissprot:CTSR3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CTSR3_HUMAN
pepstats	swissprot:CTSR3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CTSR3_HUMAN
pepwheel	swissprot:CTSR3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CTSR3_HUMAN
pepwindow	swissprot:CTSR3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CTSR3_HUMAN
sigcleave	swissprot:CTSR3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CTSR3_HUMAN
## Database	ID	URL or Descriptions
# AltName	ABCBB_HUMAN	ATP-binding cassette sub-family B member 11
# BIOPHYSICOCHEMICAL PROPERTIES	ABCBB_HUMAN	Kinetic parameters  KM=30.4 uM for taurocholate {ECO 0000269|PubMed 17264802}; Vmax=232 pmol/min/mg enzyme for taurocholate transport {ECO 0000269|PubMed 17264802}; 
# BioGrid	114199	5
# ChiTaRS	ABCB11	human
# DISEASE	ABCBB_HUMAN	Cholestasis, benign recurrent intrahepatic, 2 (BRIC2) [MIM 605479]  A disorder characterized by intermittent episodes of cholestasis without progression to liver failure. There is initial elevation of serum bile acids, followed by cholestatic jaundice which generally spontaneously resolves after periods of weeks to months. The cholestatic attacks vary in severity and duration. Patients are asymptomatic between episodes, both clinically and biochemically. {ECO 0000269|PubMed 15300568, ECO 0000269|PubMed 16039748}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ABCBB_HUMAN	Cholestasis, progressive familial intrahepatic, 2 (PFIC2) [MIM 601847]  A disorder characterized by early onset of cholestasis that progresses to hepatic fibrosis, cirrhosis, and end-stage liver disease before adulthood. {ECO 0000269|PubMed 10579978, ECO 0000269|PubMed 11815775, ECO 0000269|PubMed 24969679, ECO 0000269|PubMed 9806540}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	ABCBB_HUMAN	Multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. 
# DrugBank	DB00091	Cyclosporine
# DrugBank	DB00171	Adenosine triphosphate
# DrugBank	DB00175	Pravastatin
# DrugBank	DB00206	Reserpine
# DrugBank	DB00390	Digoxin
# DrugBank	DB00396	Progesterone
# DrugBank	DB00477	Chlorpromazine
# DrugBank	DB00501	Cimetidine
# DrugBank	DB00541	Vincristine
# DrugBank	DB00559	Bosentan
# DrugBank	DB00570	Vinblastine
# DrugBank	DB00661	Verapamil
# DrugBank	DB00675	Tamoxifen
# DrugBank	DB00693	Fluorescein
# DrugBank	DB00694	Daunorubicin
# DrugBank	DB00845	Clofazimine
# DrugBank	DB00908	Quinidine
# DrugBank	DB00977	Ethinyl Estradiol
# DrugBank	DB00997	Doxorubicin
# DrugBank	DB01016	Glyburide
# DrugBank	DB01026	Ketoconazole
# DrugBank	DB01045	Rifampicin
# DrugBank	DB01051	Novobiocin
# DrugBank	DB01098	Rosuvastatin
# DrugBank	DB01174	Phenobarbital
# DrugBank	DB01229	Paclitaxel
# DrugBank	DB01234	Dexamethasone
# DrugBank	DB01586	Ursodeoxycholic acid
# DrugBank	DB02659	Cholic Acid
# DrugBank	DB02703	Fusidic Acid
# DrugBank	DB03619	Deoxycholic Acid
# DrugBank	DB08901	Ponatinib
# Ensembl	ENST00000263817	ENSP00000263817; ENSG00000073734
# ExpressionAtlas	O95342	baseline and differential
# FUNCTION	ABCBB_HUMAN	Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0045177	apical part of cell; IEA:Ensembl.
# GO_component	GO:0046581	intercellular canaliculus; IEA:Ensembl.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005215	transporter activity; TAS:ProtInc.
# GO_function	GO:0005524	ATP binding; TAS:ProtInc.
# GO_function	GO:0008554	sodium-exporting ATPase activity, phosphorylative mechanism; TAS:ProtInc.
# GO_function	GO:0015126	canalicular bile acid transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015432	bile acid-exporting ATPase activity; TAS:Reactome.
# GO_process	GO:0006699	bile acid biosynthetic process; TAS:Reactome.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0015721	bile acid and bile salt transport; TAS:Reactome.
# GO_process	GO:0015722	canalicular bile acid transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0044281	small molecule metabolic process
# Gene3D	3.40.50.300	-; 2.
# Genevisible	O95342	HS
# HGNC	HGNC:42	ABCB11
# IntAct	O95342	2
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR011527	ABC1_TM_dom
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR027417	P-loop_NTPase
# InterPro	IPR030278	BSEP
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Disease	H00624	[Inherited metabolic disease; Liver disease] North American Indian childhood cirrhosis (NAIC)
# KEGG_Pathway	ko02010	ABC transporters
# KEGG_Pathway	ko04976	Bile secretion
# MIM	601847	phenotype
# MIM	603201	gene
# MIM	605479	phenotype
# Organism	ABCBB_HUMAN	Homo sapiens (Human)
# Orphanet	69665	Intrahepatic cholestasis of pregnancy
# Orphanet	79304	Progressive familial intrahepatic cholestasis type 2
# Orphanet	99961	Benign recurrent intrahepatic cholestasis type 2
# PANTHER	PTHR24221:SF165	PTHR24221:SF165
# PROSITE	PS00211	ABC_TRANSPORTER_1
# PROSITE	PS50893	ABC_TRANSPORTER_2; 2
# PROSITE	PS50929	ABC_TM1F; 2
# Pfam	PF00005	ABC_tran; 2
# Pfam	PF00664	ABC_membrane; 2
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-159418	Recycling of bile acids and salts
# Reactome	R-HSA-193368	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
# RecName	ABCBB_HUMAN	Bile salt export pump
# RefSeq	NP_003733	NM_003742.2
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 2 ABC transmembrane type-1 domains. {ECO:0000255|PROSITE-ProRule	PRU00441}. 
# SIMILARITY	Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA; 2
# SUBCELLULAR LOCATION	ABCBB_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Interacts with HAX1. {ECO	0000250}. 
# SUPFAM	SSF52540	SSF52540; 2
# SUPFAM	SSF90123	SSF90123; 3
# TCDB	3.A.1.201	the atp-binding cassette (abc) superfamily
# TISSUE SPECIFICITY	ABCBB_HUMAN	Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ. 
# UCSC	uc002ueo	human
# WEB RESOURCE	ABCBB_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=O95342";
# eggNOG	COG1132	LUCA
# eggNOG	KOG0055	Eukaryota
BLAST	swissprot:ABCBB_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCBB_HUMAN
BioCyc	ZFISH:ENSG00000073734-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000073734-MONOMER
COXPRESdb	8647	http://coxpresdb.jp/data/gene/8647.shtml
CleanEx	HS_ABCB11	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCB11
DOI	10.1002/hep.21214	http://dx.doi.org/10.1002/hep.21214
DOI	10.1007/s10038-002-8653-6	http://dx.doi.org/10.1007/s10038-002-8653-6
DOI	10.1016/S0016-5085(99)70287-8	http://dx.doi.org/10.1016/S0016-5085(99)70287-8
DOI	10.1016/j.jhep.2005.05.020	http://dx.doi.org/10.1016/j.jhep.2005.05.020
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/3034	http://dx.doi.org/10.1038/3034
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1053/j.gastro.2004.04.065	http://dx.doi.org/10.1053/j.gastro.2004.04.065
DOI	10.1067/mpd.2002.119993	http://dx.doi.org/10.1067/mpd.2002.119993
DOI	10.1097/00008571-200402000-00003	http://dx.doi.org/10.1097/00008571-200402000-00003
DOI	10.1097/01.fpc.0000230418.28091.76	http://dx.doi.org/10.1097/01.fpc.0000230418.28091.76
DOI	10.1124/dmd.105.008854	http://dx.doi.org/10.1124/dmd.105.008854
DOI	10.1152/ajpgi.00415.2006	http://dx.doi.org/10.1152/ajpgi.00415.2006
DOI	10.3892/mmr.2014.2349	http://dx.doi.org/10.3892/mmr.2014.2349
DrugBank	DB00091	http://www.drugbank.ca/drugs/DB00091
DrugBank	DB00171	http://www.drugbank.ca/drugs/DB00171
DrugBank	DB00175	http://www.drugbank.ca/drugs/DB00175
DrugBank	DB00206	http://www.drugbank.ca/drugs/DB00206
DrugBank	DB00390	http://www.drugbank.ca/drugs/DB00390
DrugBank	DB00396	http://www.drugbank.ca/drugs/DB00396
DrugBank	DB00477	http://www.drugbank.ca/drugs/DB00477
DrugBank	DB00501	http://www.drugbank.ca/drugs/DB00501
DrugBank	DB00541	http://www.drugbank.ca/drugs/DB00541
DrugBank	DB00559	http://www.drugbank.ca/drugs/DB00559
DrugBank	DB00570	http://www.drugbank.ca/drugs/DB00570
DrugBank	DB00661	http://www.drugbank.ca/drugs/DB00661
DrugBank	DB00675	http://www.drugbank.ca/drugs/DB00675
DrugBank	DB00693	http://www.drugbank.ca/drugs/DB00693
DrugBank	DB00694	http://www.drugbank.ca/drugs/DB00694
DrugBank	DB00845	http://www.drugbank.ca/drugs/DB00845
DrugBank	DB00908	http://www.drugbank.ca/drugs/DB00908
DrugBank	DB00977	http://www.drugbank.ca/drugs/DB00977
DrugBank	DB00997	http://www.drugbank.ca/drugs/DB00997
DrugBank	DB01016	http://www.drugbank.ca/drugs/DB01016
DrugBank	DB01026	http://www.drugbank.ca/drugs/DB01026
DrugBank	DB01045	http://www.drugbank.ca/drugs/DB01045
DrugBank	DB01051	http://www.drugbank.ca/drugs/DB01051
DrugBank	DB01098	http://www.drugbank.ca/drugs/DB01098
DrugBank	DB01174	http://www.drugbank.ca/drugs/DB01174
DrugBank	DB01229	http://www.drugbank.ca/drugs/DB01229
DrugBank	DB01234	http://www.drugbank.ca/drugs/DB01234
DrugBank	DB01586	http://www.drugbank.ca/drugs/DB01586
DrugBank	DB02659	http://www.drugbank.ca/drugs/DB02659
DrugBank	DB02703	http://www.drugbank.ca/drugs/DB02703
DrugBank	DB03619	http://www.drugbank.ca/drugs/DB03619
DrugBank	DB08901	http://www.drugbank.ca/drugs/DB08901
EMBL	AC008177	http://www.ebi.ac.uk/ena/data/view/AC008177
EMBL	AC069137	http://www.ebi.ac.uk/ena/data/view/AC069137
EMBL	AC093723	http://www.ebi.ac.uk/ena/data/view/AC093723
EMBL	AF091582	http://www.ebi.ac.uk/ena/data/view/AF091582
EMBL	AF136523	http://www.ebi.ac.uk/ena/data/view/AF136523
Ensembl	ENST00000263817	http://www.ensembl.org/id/ENST00000263817
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0045177	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045177
GO_component	GO:0046581	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046581
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0008554	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008554
GO_function	GO:0015126	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015126
GO_function	GO:0015432	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015432
GO_process	GO:0006699	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006699
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0015721	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015721
GO_process	GO:0015722	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015722
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCB11	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCB11
GeneID	8647	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8647
GeneTree	ENSGT00530000062896	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062896
H-InvDB	HIX0029772	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0029772
HGNC	HGNC:42	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:42
HOVERGEN	HBG080809	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG080809&db=HOVERGEN
HPA	HPA019035	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA019035
InParanoid	O95342	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O95342
IntAct	O95342	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O95342*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR011527	http://www.ebi.ac.uk/interpro/entry/IPR011527
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
InterPro	IPR030278	http://www.ebi.ac.uk/interpro/entry/IPR030278
Jabion	8647	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=8647
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Disease	H00624	http://www.genome.jp/dbget-bin/www_bget?H00624
KEGG_Gene	hsa:8647	http://www.genome.jp/dbget-bin/www_bget?hsa:8647
KEGG_Orthology	KO:K05664	http://www.genome.jp/dbget-bin/www_bget?KO:K05664
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
MIM	601847	http://www.ncbi.nlm.nih.gov/omim/601847
MIM	603201	http://www.ncbi.nlm.nih.gov/omim/603201
MIM	605479	http://www.ncbi.nlm.nih.gov/omim/605479
MINT	MINT-5003953	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5003953
OMA	CAFLHGI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CAFLHGI
Orphanet	69665	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=69665
Orphanet	79304	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=79304
Orphanet	99961	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=99961
OrthoDB	EOG091G0HVA	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0HVA
PANTHER	PTHR24221:SF165	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24221:SF165
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PROSITE	PS50929	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929
PSORT	swissprot:ABCBB_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCBB_HUMAN
PSORT-B	swissprot:ABCBB_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCBB_HUMAN
PSORT2	swissprot:ABCBB_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCBB_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF00664	http://pfam.xfam.org/family/PF00664
PharmGKB	PA374	http://www.pharmgkb.org/do/serve?objId=PA374&objCls=Gene
Phobius	swissprot:ABCBB_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCBB_HUMAN
PhylomeDB	O95342	http://phylomedb.org/?seqid=O95342
ProteinModelPortal	O95342	http://www.proteinmodelportal.org/query/uniprot/O95342
PubMed	10579978	http://www.ncbi.nlm.nih.gov/pubmed/10579978
PubMed	11815775	http://www.ncbi.nlm.nih.gov/pubmed/11815775
PubMed	11829140	http://www.ncbi.nlm.nih.gov/pubmed/11829140
PubMed	15077010	http://www.ncbi.nlm.nih.gov/pubmed/15077010
PubMed	15300568	http://www.ncbi.nlm.nih.gov/pubmed/15300568
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	16039748	http://www.ncbi.nlm.nih.gov/pubmed/16039748
PubMed	16763017	http://www.ncbi.nlm.nih.gov/pubmed/16763017
PubMed	16799996	http://www.ncbi.nlm.nih.gov/pubmed/16799996
PubMed	17082223	http://www.ncbi.nlm.nih.gov/pubmed/17082223
PubMed	17264802	http://www.ncbi.nlm.nih.gov/pubmed/17264802
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	24969679	http://www.ncbi.nlm.nih.gov/pubmed/24969679
PubMed	9806540	http://www.ncbi.nlm.nih.gov/pubmed/9806540
Reactome	R-HSA-159418	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-159418
Reactome	R-HSA-193368	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-193368
RefSeq	NP_003733	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003733
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	O95342	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O95342
STRING	9606.ENSP00000263817	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000263817&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
SUPFAM	SSF90123	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123
TCDB	3.A.1.201	http://www.tcdb.org/search/result.php?tc=3.A.1.201
UCSC	uc002ueo	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ueo&org=rat
UniGene	Hs.658439	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.658439
UniProtKB	ABCBB_HUMAN	http://www.uniprot.org/uniprot/ABCBB_HUMAN
UniProtKB-AC	O95342	http://www.uniprot.org/uniprot/O95342
charge	swissprot:ABCBB_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCBB_HUMAN
eggNOG	COG1132	http://eggnogapi.embl.de/nog_data/html/tree/COG1132
eggNOG	KOG0055	http://eggnogapi.embl.de/nog_data/html/tree/KOG0055
epestfind	swissprot:ABCBB_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCBB_HUMAN
garnier	swissprot:ABCBB_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCBB_HUMAN
helixturnhelix	swissprot:ABCBB_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCBB_HUMAN
hmoment	swissprot:ABCBB_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCBB_HUMAN
iep	swissprot:ABCBB_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCBB_HUMAN
inforesidue	swissprot:ABCBB_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCBB_HUMAN
neXtProt	NX_O95342	http://www.nextprot.org/db/entry/NX_O95342
octanol	swissprot:ABCBB_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCBB_HUMAN
pepcoil	swissprot:ABCBB_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCBB_HUMAN
pepdigest	swissprot:ABCBB_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCBB_HUMAN
pepinfo	swissprot:ABCBB_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCBB_HUMAN
pepnet	swissprot:ABCBB_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCBB_HUMAN
pepstats	swissprot:ABCBB_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCBB_HUMAN
pepwheel	swissprot:ABCBB_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCBB_HUMAN
pepwindow	swissprot:ABCBB_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCBB_HUMAN
sigcleave	swissprot:ABCBB_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCBB_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	939591	34
# Ensembl	ENST00000580018	ENSP00000464522; ENSG00000265354
# FUNCTION	TIM23_HUMAN	Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. 
# GO_component	GO:0005739	mitochondrion; IDA:HPA.
# GO_component	GO:0005743	mitochondrial inner membrane; IDA:UniProtKB.
# GO_component	GO:0005744	mitochondrial inner membrane presequence translocase complex; IDA:BHF-UCL.
# GO_component	GO:0005758	mitochondrial intermembrane space; IDA:MGI.
# GO_component	GO:0031305	integral component of mitochondrial inner membrane; IDA:BHF-UCL.
# GO_function	GO:0015266	protein channel activity; IBA:GO_Central.
# GO_function	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity; IEA:InterPro.
# GO_process	GO:0006626	protein targeting to mitochondrion; TAS:ProtInc.
# GO_process	GO:0030150	protein import into mitochondrial matrix; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006605	protein targeting
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	O14925	HS
# HGNC	HGNC:17312	TIMM23
# INTERACTION	TIM23_HUMAN	Q9BVV7 TIMM21; NbExp=3; IntAct=EBI-1047996, EBI-6570759; 
# IntAct	O14925	24
# InterPro	IPR003397	Tim17/Tim22/Tim23/PMP24
# InterPro	IPR005681	Tim23
# MIM	605034	gene
# Organism	TIM23_HUMAN	Homo sapiens (Human)
# Pfam	PF02466	Tim17
# Proteomes	UP000005640	Chromosome 10
# Reactome	R-HSA-1268020	Mitochondrial protein import
# RecName	TIM23_HUMAN	Mitochondrial import inner membrane translocase subunit Tim23
# RefSeq	NP_006318	NM_006327.3
# SIMILARITY	Belongs to the Tim17/Tim22/Tim23 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	TIM23_HUMAN	Mitochondrion inner membrane {ECO 0000269|PubMed 25997101}; Multi-pass membrane protein {ECO 0000255}. 
# SUBUNIT	TIM23_HUMAN	Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50; within this complex, directly interacts with TIMM50. The complex interacts with the TIMM44 component of the PAM complex and with DNAJC15. {ECO 0000269|PubMed 15044455, ECO 0000269|PubMed 23263864}. 
# TIGRFAMs	TIGR00983	3a0801s02tim23
# UCSC	uc001jiu	human
# eggNOG	COG5596	LUCA
# eggNOG	KOG3324	Eukaryota
BLAST	swissprot:TIM23_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TIM23_HUMAN
BioCyc	ZFISH:ENSG00000138297-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000138297-MONOMER
COXPRESdb	100287932	http://coxpresdb.jp/data/gene/100287932.shtml
CleanEx	HS_TIMM23	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TIMM23
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/jmbi.1999.2751	http://dx.doi.org/10.1006/jmbi.1999.2751
DOI	10.1038/nature02462	http://dx.doi.org/10.1038/nature02462
DOI	10.1074/jbc.M402049200	http://dx.doi.org/10.1074/jbc.M402049200
DOI	10.1093/hmg/dds541	http://dx.doi.org/10.1093/hmg/dds541
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.7554/eLife.06265	http://dx.doi.org/10.7554/eLife.06265
EMBL	AF030162	http://www.ebi.ac.uk/ena/data/view/AF030162
EMBL	AK223331	http://www.ebi.ac.uk/ena/data/view/AK223331
EMBL	AL450342	http://www.ebi.ac.uk/ena/data/view/AL450342
EMBL	AY442341	http://www.ebi.ac.uk/ena/data/view/AY442341
EMBL	BC062707	http://www.ebi.ac.uk/ena/data/view/BC062707
EMBL	BC066951	http://www.ebi.ac.uk/ena/data/view/BC066951
Ensembl	ENST00000580018	http://www.ensembl.org/id/ENST00000580018
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005744	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005744
GO_component	GO:0005758	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005758
GO_component	GO:0031305	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031305
GO_function	GO:0015266	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015266
GO_function	GO:0015450	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015450
GO_process	GO:0006626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006626
GO_process	GO:0030150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030150
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	TIMM23	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TIMM23
GeneID	100287932	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100287932
GeneTree	ENSGT00390000001094	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000001094
HGNC	HGNC:17312	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17312
HOGENOM	HOG000166435	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000166435&db=HOGENOM6
HOVERGEN	HBG057526	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG057526&db=HOVERGEN
HPA	HPA031408	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031408
InParanoid	O14925	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O14925
IntAct	O14925	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O14925*
InterPro	IPR003397	http://www.ebi.ac.uk/interpro/entry/IPR003397
InterPro	IPR005681	http://www.ebi.ac.uk/interpro/entry/IPR005681
Jabion	100287932	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=100287932
KEGG_Gene	hsa:100287932	http://www.genome.jp/dbget-bin/www_bget?hsa:100287932
MIM	605034	http://www.ncbi.nlm.nih.gov/omim/605034
MINT	MINT-2998436	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-2998436
OMA	MSPISPY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MSPISPY
OrthoDB	EOG091G0NP6	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0NP6
PSORT	swissprot:TIM23_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TIM23_HUMAN
PSORT-B	swissprot:TIM23_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TIM23_HUMAN
PSORT2	swissprot:TIM23_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TIM23_HUMAN
Pfam	PF02466	http://pfam.xfam.org/family/PF02466
PharmGKB	PA38227	http://www.pharmgkb.org/do/serve?objId=PA38227&objCls=Gene
Phobius	swissprot:TIM23_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TIM23_HUMAN
PhylomeDB	O14925	http://phylomedb.org/?seqid=O14925
ProteinModelPortal	O14925	http://www.proteinmodelportal.org/query/uniprot/O14925
PubMed	10339406	http://www.ncbi.nlm.nih.gov/pubmed/10339406
PubMed	15044455	http://www.ncbi.nlm.nih.gov/pubmed/15044455
PubMed	15164054	http://www.ncbi.nlm.nih.gov/pubmed/15164054
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	23263864	http://www.ncbi.nlm.nih.gov/pubmed/23263864
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	25997101	http://www.ncbi.nlm.nih.gov/pubmed/25997101
Reactome	R-HSA-1268020	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1268020
RefSeq	NP_006318	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006318
STRING	9606.ENSP00000260867	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000260867&targetmode=cogs
TIGRFAMs	TIGR00983	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00983
UCSC	uc001jiu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001jiu&org=rat
UniGene	Hs.524308	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.524308
UniGene	Hs.661964	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.661964
UniProtKB	TIM23_HUMAN	http://www.uniprot.org/uniprot/TIM23_HUMAN
UniProtKB-AC	O14925	http://www.uniprot.org/uniprot/O14925
charge	swissprot:TIM23_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TIM23_HUMAN
eggNOG	COG5596	http://eggnogapi.embl.de/nog_data/html/tree/COG5596
eggNOG	KOG3324	http://eggnogapi.embl.de/nog_data/html/tree/KOG3324
epestfind	swissprot:TIM23_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TIM23_HUMAN
garnier	swissprot:TIM23_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TIM23_HUMAN
helixturnhelix	swissprot:TIM23_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TIM23_HUMAN
hmoment	swissprot:TIM23_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TIM23_HUMAN
iep	swissprot:TIM23_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TIM23_HUMAN
inforesidue	swissprot:TIM23_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TIM23_HUMAN
neXtProt	NX_O14925	http://www.nextprot.org/db/entry/NX_O14925
octanol	swissprot:TIM23_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TIM23_HUMAN
pepcoil	swissprot:TIM23_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TIM23_HUMAN
pepdigest	swissprot:TIM23_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TIM23_HUMAN
pepinfo	swissprot:TIM23_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TIM23_HUMAN
pepnet	swissprot:TIM23_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TIM23_HUMAN
pepstats	swissprot:TIM23_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TIM23_HUMAN
pepwheel	swissprot:TIM23_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TIM23_HUMAN
pepwindow	swissprot:TIM23_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TIM23_HUMAN
sigcleave	swissprot:TIM23_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TIM23_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TMC2_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8TDI7-1; Sequence=Displayed; Name=2; IsoId=Q8TDI7-3; Sequence=VSP_015281, VSP_015282; Note=No experimental confirmation available.; Name=3; IsoId=Q8TDI7-4; Sequence=VSP_015279, VSP_015283, VSP_015284; Note=No experimental confirmation available.; 
# AltName	TMC2_HUMAN	Transmembrane cochlear-expressed protein 2
# CCDS	CCDS13029	-. [Q8TDI7-1]
# Ensembl	ENST00000358864	ENSP00000351732; ENSG00000149488. [Q8TDI7-1]
# FUNCTION	TMC2_HUMAN	Probable ion channel required for the normal function of cochlear hair cells. {ECO 0000269|PubMed 11850618}. 
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0032426	stereocilium tip; IEA:Ensembl.
# GO_function	GO:0005245	voltage-gated calcium channel activity; IEA:Ensembl.
# GO_process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound; IEA:Ensembl.
# GO_process	GO:0060005	vestibular reflex; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# Genevisible	Q8TDI7	HS
# HGNC	HGNC:16527	TMC2
# InterPro	IPR012496	TMC
# MIM	606707	gene
# Organism	TMC2_HUMAN	Homo sapiens (Human)
# Pfam	PF07810	TMC
# Proteomes	UP000005640	Chromosome 20
# RecName	TMC2_HUMAN	Transmembrane channel-like protein 2
# RefSeq	NP_542789	NM_080751.2. [Q8TDI7-1]
# SEQUENCE CAUTION	Sequence=AAQ88976.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC04423.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the TMC family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	TMC2_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TISSUE SPECIFICITY	TMC2_HUMAN	Detected in fetal cochlea. 
# UCSC	uc002wgf	human. [Q8TDI7-1]
# eggNOG	ENOG410IF2J	Eukaryota
# eggNOG	ENOG410XTGF	LUCA
BLAST	swissprot:TMC2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TMC2_HUMAN
BioCyc	ZFISH:ENSG00000149488-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000149488-MONOMER
COXPRESdb	117532	http://coxpresdb.jp/data/gene/117532.shtml
DOI	10.1038/414865a	http://dx.doi.org/10.1038/414865a
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/ng842	http://dx.doi.org/10.1038/ng842
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
EMBL	AF417580	http://www.ebi.ac.uk/ena/data/view/AF417580
EMBL	AK094789	http://www.ebi.ac.uk/ena/data/view/AK094789
EMBL	AK127751	http://www.ebi.ac.uk/ena/data/view/AK127751
EMBL	AL049712	http://www.ebi.ac.uk/ena/data/view/AL049712
EMBL	AY358613	http://www.ebi.ac.uk/ena/data/view/AY358613
Ensembl	ENST00000358864	http://www.ensembl.org/id/ENST00000358864
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0032426	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032426
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_process	GO:0050910	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050910
GO_process	GO:0060005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060005
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	TMC2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TMC2
GeneID	117532	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=117532
GeneTree	ENSGT00760000119171	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119171
H-InvDB	HIX0022417	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0022417
HGNC	HGNC:16527	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16527
HOVERGEN	HBG036209	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG036209&db=HOVERGEN
HPA	HPA046350	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA046350
InParanoid	Q8TDI7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8TDI7
InterPro	IPR012496	http://www.ebi.ac.uk/interpro/entry/IPR012496
Jabion	117532	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=117532
KEGG_Gene	hsa:117532	http://www.genome.jp/dbget-bin/www_bget?hsa:117532
MIM	606707	http://www.ncbi.nlm.nih.gov/omim/606707
OMA	NRMYDVL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NRMYDVL
OrthoDB	EOG091G00X0	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00X0
PSORT	swissprot:TMC2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TMC2_HUMAN
PSORT-B	swissprot:TMC2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TMC2_HUMAN
PSORT2	swissprot:TMC2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TMC2_HUMAN
Pfam	PF07810	http://pfam.xfam.org/family/PF07810
PharmGKB	PA38158	http://www.pharmgkb.org/do/serve?objId=PA38158&objCls=Gene
Phobius	swissprot:TMC2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TMC2_HUMAN
PhylomeDB	Q8TDI7	http://phylomedb.org/?seqid=Q8TDI7
ProteinModelPortal	Q8TDI7	http://www.proteinmodelportal.org/query/uniprot/Q8TDI7
PubMed	11780052	http://www.ncbi.nlm.nih.gov/pubmed/11780052
PubMed	11850618	http://www.ncbi.nlm.nih.gov/pubmed/11850618
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
RefSeq	NP_542789	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_542789
UCSC	uc002wgf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002wgf&org=rat
UniGene	Hs.352626	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.352626
UniProtKB	TMC2_HUMAN	http://www.uniprot.org/uniprot/TMC2_HUMAN
UniProtKB-AC	Q8TDI7	http://www.uniprot.org/uniprot/Q8TDI7
charge	swissprot:TMC2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TMC2_HUMAN
eggNOG	ENOG410IF2J	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IF2J
eggNOG	ENOG410XTGF	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XTGF
epestfind	swissprot:TMC2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TMC2_HUMAN
garnier	swissprot:TMC2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TMC2_HUMAN
helixturnhelix	swissprot:TMC2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TMC2_HUMAN
hmoment	swissprot:TMC2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TMC2_HUMAN
iep	swissprot:TMC2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TMC2_HUMAN
inforesidue	swissprot:TMC2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TMC2_HUMAN
neXtProt	NX_Q8TDI7	http://www.nextprot.org/db/entry/NX_Q8TDI7
octanol	swissprot:TMC2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TMC2_HUMAN
pepcoil	swissprot:TMC2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TMC2_HUMAN
pepdigest	swissprot:TMC2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TMC2_HUMAN
pepinfo	swissprot:TMC2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TMC2_HUMAN
pepnet	swissprot:TMC2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TMC2_HUMAN
pepstats	swissprot:TMC2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TMC2_HUMAN
pepwheel	swissprot:TMC2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TMC2_HUMAN
pepwindow	swissprot:TMC2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TMC2_HUMAN
sigcleave	swissprot:TMC2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TMC2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	5HT3B_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O95264-1; Sequence=Displayed; Name=2; IsoId=O95264-2; Sequence=VSP_029796; 
# AltName	5HT3B_HUMAN	Serotonin receptor 3B
# CCDS	CCDS8364	-. [O95264-1]
# DrugBank	DB00898	Ethanol
# DrugBank	DB01049	Ergoloid mesylate
# Ensembl	ENST00000260191	ENSP00000260191; ENSG00000149305. [O95264-1]
# Ensembl	ENST00000537778	ENSP00000443118; ENSG00000149305. [O95264-2]
# ExpressionAtlas	O95264	baseline and differential
# FUNCTION	5HT3B_HUMAN	This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. {ECO 0000269|PubMed 12867984}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IEA:Ensembl.
# GO_component	GO:0009986	cell surface; IDA:CACAO.
# GO_component	GO:0045211	postsynaptic membrane; IEA:InterPro.
# GO_component	GO:1904602	serotonin-activated cation-selective channel complex; IGI:GO_Central.
# GO_function	GO:0005232	serotonin-activated cation-selective channel activity; IGI:GO_Central.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.370	-; 2.
# Gene3D	2.70.170.10	-; 1.
# Genevisible	O95264	HS
# HGNC	HGNC:5298	HTR3B
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR008132	5HT3_rcpt
# InterPro	IPR008134	5HT3_rcpt_B
# InterPro	IPR027361	Acetylcholine_rcpt_TM
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04726	Serotonergic synapse
# MIM	604654	gene
# MISCELLANEOUS	5HT3B_HUMAN	The HA-stretch region of HTR3B seems to confer increased conductance to HTR3A/HTR3B heteromers compared to that of HTR3A homomers. 
# Organism	5HT3B_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR18945	PTHR18945
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR01708	5HT3RECEPTOR
# PRINTS	PR01710	5HT3BRECEPTR
# PTM	5HT3B_HUMAN	N-glycosylation required for membrane localization. {ECO 0000269|PubMed 21138434}. 
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-975298	Ligand-gated ion channel transport
# RecName	5HT3B_HUMAN	5-hydroxytryptamine receptor 3B
# RefSeq	NP_006019	NM_006028.4. [O95264-1]
# RefSeq	XP_011541365	XM_011543063.1. [O95264-2]
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3B sub-subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	5HT3B_HUMAN	Cell membrane {ECO 0000269|PubMed 21138434}; Multi-pass membrane protein {ECO 0000269|PubMed 21138434}. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. 
# SUBUNIT	5HT3B_HUMAN	Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex. {ECO 0000269|PubMed 17392525, ECO 0000269|PubMed 9950429}. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TIGRFAMs	TIGR00860	LIC
# TISSUE SPECIFICITY	5HT3B_HUMAN	Expressed in the brain cortex, in the caudate nucleus, the hyppocampus, the thalamus and the amygdala. Detected in the kidney and testis as well as in monocytes of the spleen, small and large intestine, uterus, prostate, ovary and placenta. {ECO 0000269|PubMed 10521471, ECO 0000269|PubMed 9950429}. 
# TopDownProteomics	O95264-1	-. [O95264-1]
# UCSC	uc001pok	human. [O95264-1]
# eggNOG	ENOG410XQGR	LUCA
# eggNOG	KOG3645	Eukaryota
BLAST	swissprot:5HT3B_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:5HT3B_HUMAN
BioCyc	ZFISH:ENSG00000149305-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000149305-MONOMER
COXPRESdb	9177	http://coxpresdb.jp/data/gene/9177.shtml
CleanEx	HS_HTR3B	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_HTR3B
DOI	10.1002/ajmg.b.30070	http://dx.doi.org/10.1002/ajmg.b.30070
DOI	10.1007/s10067-004-0927-2	http://dx.doi.org/10.1007/s10067-004-0927-2
DOI	10.1016/j.biopsych.2005.11.008	http://dx.doi.org/10.1016/j.biopsych.2005.11.008
DOI	10.1016/j.gene.2006.08.002	http://dx.doi.org/10.1016/j.gene.2006.08.002
DOI	10.1038/16941	http://dx.doi.org/10.1038/16941
DOI	10.1038/nature01788	http://dx.doi.org/10.1038/nature01788
DOI	10.1038/nature09629	http://dx.doi.org/10.1038/nature09629
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.274.43.30799	http://dx.doi.org/10.1074/jbc.274.43.30799
DOI	10.1111/j.1471-4159.2010.07129.x	http://dx.doi.org/10.1111/j.1471-4159.2010.07129.x
DOI	10.1124/mol.106.032144	http://dx.doi.org/10.1124/mol.106.032144
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01049	http://www.drugbank.ca/drugs/DB01049
EMBL	AF080582	http://www.ebi.ac.uk/ena/data/view/AF080582
EMBL	AF169255	http://www.ebi.ac.uk/ena/data/view/AF169255
EMBL	AK314268	http://www.ebi.ac.uk/ena/data/view/AK314268
EMBL	AM293589	http://www.ebi.ac.uk/ena/data/view/AM293589
EMBL	EF444985	http://www.ebi.ac.uk/ena/data/view/EF444985
Ensembl	ENST00000260191	http://www.ensembl.org/id/ENST00000260191
Ensembl	ENST00000537778	http://www.ensembl.org/id/ENST00000537778
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_component	GO:1904602	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1904602
GO_function	GO:0005232	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005232
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.370	http://www.cathdb.info/version/latest/superfamily/1.20.120.370
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	HTR3B	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=HTR3B
GeneID	9177	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9177
GeneTree	ENSGT00790000122957	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00790000122957
HGNC	HGNC:5298	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:5298
HOGENOM	HOG000241519	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000241519&db=HOGENOM6
HOVERGEN	HBG106638	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG106638&db=HOVERGEN
HPA	HPA039559	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA039559
InParanoid	O95264	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O95264
IntAct	O95264	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O95264*
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR008132	http://www.ebi.ac.uk/interpro/entry/IPR008132
InterPro	IPR008134	http://www.ebi.ac.uk/interpro/entry/IPR008134
InterPro	IPR027361	http://www.ebi.ac.uk/interpro/entry/IPR027361
Jabion	9177	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9177
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:9177	http://www.genome.jp/dbget-bin/www_bget?hsa:9177
KEGG_Orthology	KO:K04819	http://www.genome.jp/dbget-bin/www_bget?KO:K04819
KEGG_Pathway	ko04726	http://www.genome.jp/kegg-bin/show_pathway?ko04726
MIM	604654	http://www.ncbi.nlm.nih.gov/omim/604654
OMA	FDRLLFQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FDRLLFQ
OrthoDB	EOG091G08WI	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08WI
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR01708	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01708
PRINTS	PR01710	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01710
PSORT	swissprot:5HT3B_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:5HT3B_HUMAN
PSORT-B	swissprot:5HT3B_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:5HT3B_HUMAN
PSORT2	swissprot:5HT3B_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:5HT3B_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA29556	http://www.pharmgkb.org/do/serve?objId=PA29556&objCls=Gene
Phobius	swissprot:5HT3B_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:5HT3B_HUMAN
PhylomeDB	O95264	http://phylomedb.org/?seqid=O95264
ProteinModelPortal	O95264	http://www.proteinmodelportal.org/query/uniprot/O95264
PubMed	10521471	http://www.ncbi.nlm.nih.gov/pubmed/10521471
PubMed	12867984	http://www.ncbi.nlm.nih.gov/pubmed/12867984
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15293096	http://www.ncbi.nlm.nih.gov/pubmed/15293096
PubMed	15389765	http://www.ncbi.nlm.nih.gov/pubmed/15389765
PubMed	16487942	http://www.ncbi.nlm.nih.gov/pubmed/16487942
PubMed	17010535	http://www.ncbi.nlm.nih.gov/pubmed/17010535
PubMed	17392525	http://www.ncbi.nlm.nih.gov/pubmed/17392525
PubMed	21138434	http://www.ncbi.nlm.nih.gov/pubmed/21138434
PubMed	21179162	http://www.ncbi.nlm.nih.gov/pubmed/21179162
PubMed	9950429	http://www.ncbi.nlm.nih.gov/pubmed/9950429
Reactome	R-HSA-975298	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-975298
RefSeq	NP_006019	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006019
RefSeq	XP_011541365	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011541365
STRING	9606.ENSP00000260191	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000260191&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc001pok	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001pok&org=rat
UniGene	Hs.241377	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.241377
UniProtKB	5HT3B_HUMAN	http://www.uniprot.org/uniprot/5HT3B_HUMAN
UniProtKB-AC	O95264	http://www.uniprot.org/uniprot/O95264
charge	swissprot:5HT3B_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:5HT3B_HUMAN
eggNOG	ENOG410XQGR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQGR
eggNOG	KOG3645	http://eggnogapi.embl.de/nog_data/html/tree/KOG3645
epestfind	swissprot:5HT3B_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:5HT3B_HUMAN
garnier	swissprot:5HT3B_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:5HT3B_HUMAN
helixturnhelix	swissprot:5HT3B_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:5HT3B_HUMAN
hmoment	swissprot:5HT3B_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:5HT3B_HUMAN
iep	swissprot:5HT3B_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:5HT3B_HUMAN
inforesidue	swissprot:5HT3B_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:5HT3B_HUMAN
neXtProt	NX_O95264	http://www.nextprot.org/db/entry/NX_O95264
octanol	swissprot:5HT3B_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:5HT3B_HUMAN
pepcoil	swissprot:5HT3B_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:5HT3B_HUMAN
pepdigest	swissprot:5HT3B_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:5HT3B_HUMAN
pepinfo	swissprot:5HT3B_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:5HT3B_HUMAN
pepnet	swissprot:5HT3B_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:5HT3B_HUMAN
pepstats	swissprot:5HT3B_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:5HT3B_HUMAN
pepwheel	swissprot:5HT3B_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:5HT3B_HUMAN
pepwindow	swissprot:5HT3B_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:5HT3B_HUMAN
sigcleave	swissprot:5HT3B_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:5HT3B_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ATP5J_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P18859-1; Sequence=Displayed; Name=2; IsoId=P18859-2; Sequence=VSP_046187; 
# BioGrid	107006	49
# CCDS	CCDS13574	-. [P18859-1]
# CCDS	CCDS46637	-. [P18859-2]
# ChiTaRS	ATP5J	human
# Ensembl	ENST00000284971	ENSP00000284971; ENSG00000154723. [P18859-1]
# Ensembl	ENST00000400087	ENSP00000382959; ENSG00000154723. [P18859-1]
# Ensembl	ENST00000400090	ENSP00000382962; ENSG00000154723. [P18859-1]
# Ensembl	ENST00000400093	ENSP00000382965; ENSG00000154723. [P18859-1]
# Ensembl	ENST00000400094	ENSP00000382966; ENSG00000154723. [P18859-1]
# Ensembl	ENST00000457143	ENSP00000389649; ENSG00000154723. [P18859-2]
# ExpressionAtlas	P18859	baseline and differential
# FUNCTION	ATP5J_HUMAN	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes. 
# GO_component	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); IEA:Ensembl.
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0005753	mitochondrial proton-transporting ATP synthase complex; IDA:UniProtKB.
# GO_function	GO:0005215	transporter activity; NAS:ProtInc.
# GO_function	GO:0015078	hydrogen ion transmembrane transporter activity; IEA:InterPro.
# GO_function	GO:0022857	transmembrane transporter activity; IC:UniProtKB.
# GO_process	GO:0006754	ATP biosynthetic process; TAS:Reactome.
# GO_process	GO:0021762	substantia nigra development; IEP:UniProtKB.
# GO_process	GO:0042776	mitochondrial ATP synthesis coupled proton transport; IC:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P18859	HS
# HGNC	HGNC:847	ATP5J
# IntAct	P18859	28
# InterPro	IPR008387	ATP_synth_f6_mt
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	603152	gene
# Organism	ATP5J_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12441	PTHR12441
# PIR	JT0563	JT0563
# PIRSF	PIRSF002455	ATP_synthase_coupling_factor_6
# Pfam	PF05511	ATP-synt_F6
# Proteomes	UP000005640	Chromosome 21
# Reactome	R-HSA-163210	Formation of ATP by chemiosmotic coupling
# RecName	ATP5J_HUMAN	ATP synthase-coupling factor 6, mitochondrial
# RefSeq	NP_001003696	NM_001003696.1. [P18859-1]
# RefSeq	NP_001003697	NM_001003697.1. [P18859-1]
# RefSeq	NP_001003701	NM_001003701.1. [P18859-2]
# RefSeq	NP_001003703	NM_001003703.1. [P18859-1]
# RefSeq	NP_001307195	NM_001320266.1. [P18859-1]
# RefSeq	NP_001307196	NM_001320267.1. [P18859-1]
# RefSeq	NP_001676	NM_001685.4. [P18859-1]
# SIMILARITY	Belongs to the eukaryotic ATPase subunit F6 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	ATP5J_HUMAN	Mitochondrion. Mitochondrion inner membrane. 
# SUBUNIT	F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity). {ECO	0000250}. 
# SUPFAM	SSF111357	SSF111357
# TopDownProteomics	P18859-1	-. [P18859-1]
# UCSC	uc002ylv	human. [P18859-1]
# eggNOG	ENOG41122G1	LUCA
# eggNOG	KOG4634	Eukaryota
BLAST	swissprot:ATP5J_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ATP5J_HUMAN
BioCyc	ZFISH:ENSG00000154723-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000154723-MONOMER
COXPRESdb	522	http://coxpresdb.jp/data/gene/522.shtml
CleanEx	HS_ATP5J	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP5J
DOI	10.1002/elps.11501301201	http://dx.doi.org/10.1002/elps.11501301201
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/0006-291X(91)90178-A	http://dx.doi.org/10.1016/0006-291X(91)90178-A
DOI	10.1016/0378-1119(91)90068-M	http://dx.doi.org/10.1016/0378-1119(91)90068-M
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/35012518	http://dx.doi.org/10.1038/35012518
DOI	10.1093/dnares/dsl016	http://dx.doi.org/10.1093/dnares/dsl016
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1101/gr.GR1547R	http://dx.doi.org/10.1101/gr.GR1547R
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AL110183	http://www.ebi.ac.uk/ena/data/view/AL110183
EMBL	AP001694	http://www.ebi.ac.uk/ena/data/view/AP001694
EMBL	BC001178	http://www.ebi.ac.uk/ena/data/view/BC001178
EMBL	BT007244	http://www.ebi.ac.uk/ena/data/view/BT007244
EMBL	DT217787	http://www.ebi.ac.uk/ena/data/view/DT217787
EMBL	M37104	http://www.ebi.ac.uk/ena/data/view/M37104
EMBL	M73031	http://www.ebi.ac.uk/ena/data/view/M73031
Ensembl	ENST00000284971	http://www.ensembl.org/id/ENST00000284971
Ensembl	ENST00000400087	http://www.ensembl.org/id/ENST00000400087
Ensembl	ENST00000400090	http://www.ensembl.org/id/ENST00000400090
Ensembl	ENST00000400093	http://www.ensembl.org/id/ENST00000400093
Ensembl	ENST00000400094	http://www.ensembl.org/id/ENST00000400094
Ensembl	ENST00000457143	http://www.ensembl.org/id/ENST00000457143
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000276
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005753	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005753
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0015078	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015078
GO_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GO_process	GO:0006754	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006754
GO_process	GO:0021762	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021762
GO_process	GO:0042776	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042776
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ATP5J	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP5J
GeneID	522	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=522
GeneTree	ENSGT00390000008902	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000008902
HGNC	HGNC:847	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:847
HOGENOM	HOG000261672	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261672&db=HOGENOM6
HOVERGEN	HBG062261	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG062261&db=HOVERGEN
HPA	HPA031069	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031069
InParanoid	P18859	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P18859
IntAct	P18859	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P18859*
InterPro	IPR008387	http://www.ebi.ac.uk/interpro/entry/IPR008387
Jabion	522	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=522
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:522	http://www.genome.jp/dbget-bin/www_bget?hsa:522
KEGG_Orthology	KO:K02131	http://www.genome.jp/dbget-bin/www_bget?KO:K02131
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	603152	http://www.ncbi.nlm.nih.gov/omim/603152
MINT	MINT-3009016	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3009016
OMA	YKQKSSG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YKQKSSG
PANTHER	PTHR12441	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12441
PSORT	swissprot:ATP5J_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ATP5J_HUMAN
PSORT-B	swissprot:ATP5J_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ATP5J_HUMAN
PSORT2	swissprot:ATP5J_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ATP5J_HUMAN
Pfam	PF05511	http://pfam.xfam.org/family/PF05511
PharmGKB	PA25137	http://www.pharmgkb.org/do/serve?objId=PA25137&objCls=Gene
Phobius	swissprot:ATP5J_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ATP5J_HUMAN
PhylomeDB	P18859	http://phylomedb.org/?seqid=P18859
ProteinModelPortal	P18859	http://www.proteinmodelportal.org/query/uniprot/P18859
PubMed	10830953	http://www.ncbi.nlm.nih.gov/pubmed/10830953
PubMed	11230166	http://www.ncbi.nlm.nih.gov/pubmed/11230166
PubMed	1286669	http://www.ncbi.nlm.nih.gov/pubmed/1286669
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17213182	http://www.ncbi.nlm.nih.gov/pubmed/17213182
PubMed	1825642	http://www.ncbi.nlm.nih.gov/pubmed/1825642
PubMed	1830479	http://www.ncbi.nlm.nih.gov/pubmed/1830479
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-163210	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-163210
RefSeq	NP_001003696	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001003696
RefSeq	NP_001003697	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001003697
RefSeq	NP_001003701	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001003701
RefSeq	NP_001003703	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001003703
RefSeq	NP_001307195	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001307195
RefSeq	NP_001307196	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001307196
RefSeq	NP_001676	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001676
SMR	P18859	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P18859
STRING	9606.ENSP00000389649	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000389649&targetmode=cogs
SUPFAM	SSF111357	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF111357
SWISS-2DPAGE	P18859	http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P18859
UCSC	uc002ylv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ylv&org=rat
UniGene	Hs.246310	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.246310
UniProtKB	ATP5J_HUMAN	http://www.uniprot.org/uniprot/ATP5J_HUMAN
UniProtKB-AC	P18859	http://www.uniprot.org/uniprot/P18859
charge	swissprot:ATP5J_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ATP5J_HUMAN
eggNOG	ENOG41122G1	http://eggnogapi.embl.de/nog_data/html/tree/ENOG41122G1
eggNOG	KOG4634	http://eggnogapi.embl.de/nog_data/html/tree/KOG4634
epestfind	swissprot:ATP5J_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ATP5J_HUMAN
garnier	swissprot:ATP5J_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ATP5J_HUMAN
helixturnhelix	swissprot:ATP5J_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATP5J_HUMAN
hmoment	swissprot:ATP5J_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ATP5J_HUMAN
iep	swissprot:ATP5J_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ATP5J_HUMAN
inforesidue	swissprot:ATP5J_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ATP5J_HUMAN
neXtProt	NX_P18859	http://www.nextprot.org/db/entry/NX_P18859
octanol	swissprot:ATP5J_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ATP5J_HUMAN
pepcoil	swissprot:ATP5J_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ATP5J_HUMAN
pepdigest	swissprot:ATP5J_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ATP5J_HUMAN
pepinfo	swissprot:ATP5J_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ATP5J_HUMAN
pepnet	swissprot:ATP5J_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ATP5J_HUMAN
pepstats	swissprot:ATP5J_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ATP5J_HUMAN
pepwheel	swissprot:ATP5J_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ATP5J_HUMAN
pepwindow	swissprot:ATP5J_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ATP5J_HUMAN
sigcleave	swissprot:ATP5J_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ATP5J_HUMAN
## Database	ID	URL or Descriptions
# AltName	IPO7_HUMAN	Ran-binding protein 7
# BioGrid	115782	94
# ChiTaRS	IPO7	human
# Ensembl	ENST00000379719	ENSP00000369042; ENSG00000205339
# ExpressionAtlas	O95373	baseline and differential
# FUNCTION	IPO7_HUMAN	Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In vitro, mediates the nuclear import of HIV-1 reverse transcription complex (RTC) integrase. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. {ECO 0000269|PubMed 10228156, ECO 0000269|PubMed 12853482, ECO 0000269|PubMed 9687515}. 
# GO_component	GO:0005643	nuclear pore; TAS:ProtInc.
# GO_component	GO:0005654	nucleoplasm; IDA:HPA.
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0005829	cytosol; IBA:GO_Central.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_function	GO:0005215	transporter activity; TAS:ProtInc.
# GO_function	GO:0008536	Ran GTPase binding; TAS:ProtInc.
# GO_function	GO:0008565	protein transporter activity; IBA:GO_Central.
# GO_function	GO:0030695	GTPase regulator activity; TAS:ProtInc.
# GO_function	GO:0046332	SMAD binding; IPI:UniProtKB.
# GO_process	GO:0006606	protein import into nucleus; IBA:GO_Central.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0016032	viral process; IEA:UniProtKB-KW.
# GO_process	GO:0045087	innate immune response; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0030234	enzyme regulator activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# Gene3D	1.25.10.10	-; 2.
# Genevisible	O95373	HS
# HGNC	HGNC:9852	IPO7
# IntAct	O95373	40
# InterPro	IPR001494	Importin-beta_N
# InterPro	IPR011989	ARM-like
# InterPro	IPR013713	Cse1
# InterPro	IPR016024	ARM-type_fold
# MIM	605586	gene
# Organism	IPO7_HUMAN	Homo sapiens (Human)
# PIR	T46501	T46501
# PROSITE	PS50166	IMPORTIN_B_NT
# Pfam	PF03810	IBN_N
# Pfam	PF08506	Cse1
# Proteomes	UP000005640	Chromosome 11
# RecName	IPO7_HUMAN	Importin-7
# RefSeq	NP_006382	NM_006391.2
# SIMILARITY	Belongs to the importin beta family. {ECO	0000305}. 
# SIMILARITY	Contains 1 importin N-terminal domain. {ECO:0000255|PROSITE-ProRule	PRU00115}.
# SMART	SM00913	IBN_N
# SUBCELLULAR LOCATION	IPO7_HUMAN	Cytoplasm. Nucleus. 
# SUBUNIT	IPO7_HUMAN	Interacts with H2A, H2B, H3 and H4 histones (By similarity). Forms a heterodimer with KPNB1. Interacts with KPNB1, SNUPN, XPO1, RPL23A, RPS7, RPL5 and HIV-1 reverse transcription complex integrase. Binds directly to nuclear pore complexes (By similarity). Interacts with H2A, H2B, H3 and H4 histones. Binds to HIV-1 Rev. Interacts with SMAD4 and NUP93; translocates SMAD4 to the nucleus through the NPC upon BMP7 stimulation resulting in activation of SMAD4 signaling (PubMed 26878725). {ECO 0000250, ECO 0000269|PubMed 10209022, ECO 0000269|PubMed 10228156, ECO 0000269|PubMed 12853482, ECO 0000269|PubMed 16704975, ECO 0000269|PubMed 26878725, ECO 0000269|PubMed 9687515}. 
# SUPFAM	SSF48371	SSF48371; 2
# TCDB	1.I.1.1	the nuclear pore complex (npc) family
# UCSC	uc001mho	human
# eggNOG	COG5656	LUCA
# eggNOG	KOG1991	Eukaryota
BLAST	swissprot:IPO7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:IPO7_HUMAN
BioCyc	ZFISH:ENSG00000166472-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000166472-MONOMER
COXPRESdb	10527	http://coxpresdb.jp/data/gene/10527.shtml
CleanEx	HS_IPO7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_IPO7
DIP	DIP-32574N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-32574N
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1038/nbt810	http://dx.doi.org/10.1038/nbt810
DOI	10.1038/ng.3512	http://dx.doi.org/10.1038/ng.3512
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1074/jbc.M602189200	http://dx.doi.org/10.1074/jbc.M602189200
DOI	10.1074/mcp.M111.015131	http://dx.doi.org/10.1074/mcp.M111.015131
DOI	10.1083/jcb.138.1.65	http://dx.doi.org/10.1083/jcb.138.1.65
DOI	10.1083/jcb.145.2.255	http://dx.doi.org/10.1083/jcb.145.2.255
DOI	10.1093/emboj/17.15.4491	http://dx.doi.org/10.1093/emboj/17.15.4491
DOI	10.1093/emboj/18.9.2411	http://dx.doi.org/10.1093/emboj/18.9.2411
DOI	10.1093/emboj/cdg357	http://dx.doi.org/10.1093/emboj/cdg357
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AC055845	http://www.ebi.ac.uk/ena/data/view/AC055845
EMBL	AF098799	http://www.ebi.ac.uk/ena/data/view/AF098799
EMBL	AJ295844	http://www.ebi.ac.uk/ena/data/view/AJ295844
EMBL	AK312885	http://www.ebi.ac.uk/ena/data/view/AK312885
EMBL	AL137335	http://www.ebi.ac.uk/ena/data/view/AL137335
EMBL	BC114929	http://www.ebi.ac.uk/ena/data/view/BC114929
EMBL	CH471064	http://www.ebi.ac.uk/ena/data/view/CH471064
Ensembl	ENST00000379719	http://www.ensembl.org/id/ENST00000379719
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005643	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005643
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0008536	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008536
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0030695	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030695
GO_function	GO:0046332	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046332
GO_process	GO:0006606	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006606
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0016032	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016032
GO_process	GO:0045087	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045087
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0030234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
GeneCards	IPO7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=IPO7
GeneID	10527	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10527
GeneTree	ENSGT00550000074736	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074736
HGNC	HGNC:9852	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:9852
HOGENOM	HOG000006586	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006586&db=HOGENOM6
HOVERGEN	HBG006824	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006824&db=HOVERGEN
HPA	HPA019002	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA019002
HPA	HPA056590	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA056590
InParanoid	O95373	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O95373
IntAct	O95373	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O95373*
InterPro	IPR001494	http://www.ebi.ac.uk/interpro/entry/IPR001494
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR013713	http://www.ebi.ac.uk/interpro/entry/IPR013713
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
Jabion	10527	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10527
KEGG_Gene	hsa:10527	http://www.genome.jp/dbget-bin/www_bget?hsa:10527
MIM	605586	http://www.ncbi.nlm.nih.gov/omim/605586
MINT	MINT-5003960	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5003960
OMA	PIDEYQI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PIDEYQI
OrthoDB	EOG091G01IF	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01IF
PROSITE	PS50166	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50166
PSORT	swissprot:IPO7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:IPO7_HUMAN
PSORT-B	swissprot:IPO7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:IPO7_HUMAN
PSORT2	swissprot:IPO7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:IPO7_HUMAN
Pfam	PF03810	http://pfam.xfam.org/family/PF03810
Pfam	PF08506	http://pfam.xfam.org/family/PF08506
PharmGKB	PA34213	http://www.pharmgkb.org/do/serve?objId=PA34213&objCls=Gene
Phobius	swissprot:IPO7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:IPO7_HUMAN
PhylomeDB	O95373	http://phylomedb.org/?seqid=O95373
ProteinModelPortal	O95373	http://www.proteinmodelportal.org/query/uniprot/O95373
PubMed	10209022	http://www.ncbi.nlm.nih.gov/pubmed/10209022
PubMed	10228156	http://www.ncbi.nlm.nih.gov/pubmed/10228156
PubMed	12665801	http://www.ncbi.nlm.nih.gov/pubmed/12665801
PubMed	12853482	http://www.ncbi.nlm.nih.gov/pubmed/12853482
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	16704975	http://www.ncbi.nlm.nih.gov/pubmed/16704975
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22223895	http://www.ncbi.nlm.nih.gov/pubmed/22223895
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	26878725	http://www.ncbi.nlm.nih.gov/pubmed/26878725
PubMed	9214382	http://www.ncbi.nlm.nih.gov/pubmed/9214382
PubMed	9687515	http://www.ncbi.nlm.nih.gov/pubmed/9687515
RefSeq	NP_006382	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006382
SMART	SM00913	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00913
STRING	9606.ENSP00000369042	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000369042&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
TCDB	1.I.1.1	http://www.tcdb.org/search/result.php?tc=1.I.1.1
UCSC	uc001mho	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001mho&org=rat
UniGene	Hs.744911	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.744911
UniProtKB	IPO7_HUMAN	http://www.uniprot.org/uniprot/IPO7_HUMAN
UniProtKB-AC	O95373	http://www.uniprot.org/uniprot/O95373
charge	swissprot:IPO7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:IPO7_HUMAN
eggNOG	COG5656	http://eggnogapi.embl.de/nog_data/html/tree/COG5656
eggNOG	KOG1991	http://eggnogapi.embl.de/nog_data/html/tree/KOG1991
epestfind	swissprot:IPO7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:IPO7_HUMAN
garnier	swissprot:IPO7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:IPO7_HUMAN
helixturnhelix	swissprot:IPO7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:IPO7_HUMAN
hmoment	swissprot:IPO7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:IPO7_HUMAN
iep	swissprot:IPO7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:IPO7_HUMAN
inforesidue	swissprot:IPO7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:IPO7_HUMAN
neXtProt	NX_O95373	http://www.nextprot.org/db/entry/NX_O95373
octanol	swissprot:IPO7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:IPO7_HUMAN
pepcoil	swissprot:IPO7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:IPO7_HUMAN
pepdigest	swissprot:IPO7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:IPO7_HUMAN
pepinfo	swissprot:IPO7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:IPO7_HUMAN
pepnet	swissprot:IPO7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:IPO7_HUMAN
pepstats	swissprot:IPO7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:IPO7_HUMAN
pepwheel	swissprot:IPO7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:IPO7_HUMAN
pepwindow	swissprot:IPO7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:IPO7_HUMAN
sigcleave	swissprot:IPO7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:IPO7_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S28A1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O00337-1; Sequence=Displayed; Name=2; IsoId=O00337-2; Sequence=VSP_037221, VSP_037222; 
# AltName	S28A1_HUMAN	Concentrative nucleoside transporter 1
# AltName	S28A1_HUMAN	Na(+)/nucleoside cotransporter 1
# AltName	S28A1_HUMAN	Sodium-coupled nucleoside transporter 1
# AltName	S28A1_HUMAN	Solute carrier family 28 member 1
# CCDS	CCDS10334	-. [O00337-1]
# CCDS	CCDS10335	-. [O00337-2]
# ChiTaRS	SLC28A1	human
# DrugBank	DB00441	Gemcitabine
# DrugBank	DB00495	Zidovudine
# DrugBank	DB00649	Stavudine
# Ensembl	ENST00000286749	ENSP00000286749; ENSG00000156222. [O00337-1]
# Ensembl	ENST00000338602	ENSP00000341629; ENSG00000156222. [O00337-2]
# Ensembl	ENST00000394573	ENSP00000378074; ENSG00000156222. [O00337-1]
# ExpressionAtlas	O00337	baseline and differential
# FUNCTION	S28A1_HUMAN	Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition  adenosine, thymidine, cytidine, uridine >> guanosine, inosine. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_function	GO:0005337	nucleoside transmembrane transporter activity; TAS:ProtInc.
# GO_function	S28A1_HUMAN	GO 0005415 nucleoside sodium symporter activity; TAS Reactome.
# GO_function	S28A1_HUMAN	GO 0015389 pyrimidine- and adenine-specific sodium symporter activity; IBA GO_Central.
# GO_process	GO:0006139	nucleobase-containing compound metabolic process; TAS:ProtInc.
# GO_process	GO:0015858	nucleoside transport; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# Genevisible	O00337	HS
# HGNC	HGNC:11001	SLC28A1
# InterPro	IPR002668	CNT_N_dom
# InterPro	IPR008276	C_nuclsd_transpt
# InterPro	IPR011642	Gate_dom
# InterPro	IPR011657	CNT_C_dom
# InterPro	IPR018270	C_nuclsd_transpt_met_bac
# KEGG_Brite	ko02001	Solute carrier family
# MIM	606207	gene
# Organism	S28A1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10590	PTHR10590
# POLYMORPHISM	S28A1_HUMAN	Three variant forms of isoform 1 (A, B and C) are expressed in the kidney. All three variant forms have similar nucleoside transport activity. 
# Pfam	PF01773	Nucleos_tra2_N
# Pfam	PF07662	Nucleos_tra2_C
# Pfam	PF07670	Gate
# Proteomes	UP000005640	Chromosome 15
# Reactome	R-HSA-83936	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
# RecName	S28A1_HUMAN	Sodium/nucleoside cotransporter 1
# RefSeq	NP_001274691	NM_001287762.1. [O00337-1]
# RefSeq	NP_004204	NM_004213.4. [O00337-1]
# RefSeq	NP_964014	NM_201651.2. [O00337-2]
# SIMILARITY	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S28A1_HUMAN	Cell membrane; Multi-pass membrane protein. 
# TCDB	2.A.41.2	the concentrative nucleoside transporter (cnt) family
# TIGRFAMs	TIGR00804	nupC
# TISSUE SPECIFICITY	S28A1_HUMAN	Expressed in kidney. 
# UCSC	uc002blf	human. [O00337-1]
# eggNOG	COG1972	LUCA
# eggNOG	KOG3747	Eukaryota
BLAST	swissprot:S28A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S28A1_HUMAN
BioCyc	ZFISH:ENSG00000156222-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000156222-MONOMER
COXPRESdb	9154	http://coxpresdb.jp/data/gene/9154.shtml
CleanEx	HS_SLC28A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC28A1
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature04601	http://dx.doi.org/10.1038/nature04601
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.274.35.24475	http://dx.doi.org/10.1074/jbc.274.35.24475
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00441	http://www.drugbank.ca/drugs/DB00441
DrugBank	DB00495	http://www.drugbank.ca/drugs/DB00495
DrugBank	DB00649	http://www.drugbank.ca/drugs/DB00649
EMBL	AC087468	http://www.ebi.ac.uk/ena/data/view/AC087468
EMBL	AC103741	http://www.ebi.ac.uk/ena/data/view/AC103741
EMBL	AF187969	http://www.ebi.ac.uk/ena/data/view/AF187969
EMBL	AF187970	http://www.ebi.ac.uk/ena/data/view/AF187970
EMBL	AF187971	http://www.ebi.ac.uk/ena/data/view/AF187971
EMBL	AF187972	http://www.ebi.ac.uk/ena/data/view/AF187972
EMBL	AF187973	http://www.ebi.ac.uk/ena/data/view/AF187973
EMBL	AF187974	http://www.ebi.ac.uk/ena/data/view/AF187974
EMBL	AF187975	http://www.ebi.ac.uk/ena/data/view/AF187975
EMBL	AF187976	http://www.ebi.ac.uk/ena/data/view/AF187976
EMBL	AF187977	http://www.ebi.ac.uk/ena/data/view/AF187977
EMBL	AF187978	http://www.ebi.ac.uk/ena/data/view/AF187978
EMBL	AK291997	http://www.ebi.ac.uk/ena/data/view/AK291997
EMBL	BC029788	http://www.ebi.ac.uk/ena/data/view/BC029788
EMBL	BC039898	http://www.ebi.ac.uk/ena/data/view/BC039898
EMBL	BC126204	http://www.ebi.ac.uk/ena/data/view/BC126204
EMBL	BC126206	http://www.ebi.ac.uk/ena/data/view/BC126206
EMBL	U62966	http://www.ebi.ac.uk/ena/data/view/U62966
EMBL	U62967	http://www.ebi.ac.uk/ena/data/view/U62967
EMBL	U62968	http://www.ebi.ac.uk/ena/data/view/U62968
Ensembl	ENST00000286749	http://www.ensembl.org/id/ENST00000286749
Ensembl	ENST00000338602	http://www.ensembl.org/id/ENST00000338602
Ensembl	ENST00000394573	http://www.ensembl.org/id/ENST00000394573
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0005337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005337
GO_function	GO:0005415	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005415
GO_function	GO:0015389	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015389
GO_process	GO:0006139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006139
GO_process	GO:0015858	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015858
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GeneCards	SLC28A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC28A1
GeneID	9154	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9154
GeneTree	ENSGT00390000016025	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000016025
HGNC	HGNC:11001	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11001
HOVERGEN	HBG054073	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054073&db=HOVERGEN
HPA	HPA019551	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA019551
InParanoid	O00337	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O00337
InterPro	IPR002668	http://www.ebi.ac.uk/interpro/entry/IPR002668
InterPro	IPR008276	http://www.ebi.ac.uk/interpro/entry/IPR008276
InterPro	IPR011642	http://www.ebi.ac.uk/interpro/entry/IPR011642
InterPro	IPR011657	http://www.ebi.ac.uk/interpro/entry/IPR011657
InterPro	IPR018270	http://www.ebi.ac.uk/interpro/entry/IPR018270
Jabion	9154	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9154
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:9154	http://www.genome.jp/dbget-bin/www_bget?hsa:9154
KEGG_Orthology	KO:K11536	http://www.genome.jp/dbget-bin/www_bget?KO:K11536
MIM	606207	http://www.ncbi.nlm.nih.gov/omim/606207
OMA	SEICAIM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SEICAIM
OrthoDB	EOG091G05D5	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05D5
PANTHER	PTHR10590	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10590
PSORT	swissprot:S28A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S28A1_HUMAN
PSORT-B	swissprot:S28A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S28A1_HUMAN
PSORT2	swissprot:S28A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S28A1_HUMAN
Pfam	PF01773	http://pfam.xfam.org/family/PF01773
Pfam	PF07662	http://pfam.xfam.org/family/PF07662
Pfam	PF07670	http://pfam.xfam.org/family/PF07670
PharmGKB	PA387	http://www.pharmgkb.org/do/serve?objId=PA387&objCls=Gene
Phobius	swissprot:S28A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S28A1_HUMAN
PhylomeDB	O00337	http://phylomedb.org/?seqid=O00337
ProteinModelPortal	O00337	http://www.proteinmodelportal.org/query/uniprot/O00337
PubMed	10455109	http://www.ncbi.nlm.nih.gov/pubmed/10455109
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16572171	http://www.ncbi.nlm.nih.gov/pubmed/16572171
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	9124315	http://www.ncbi.nlm.nih.gov/pubmed/9124315
Reactome	R-HSA-83936	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-83936
RefSeq	NP_001274691	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001274691
RefSeq	NP_004204	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004204
RefSeq	NP_964014	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_964014
SMR	O00337	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O00337
STRING	9606.ENSP00000286749	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000286749&targetmode=cogs
TCDB	2.A.41.2	http://www.tcdb.org/search/result.php?tc=2.A.41.2
TIGRFAMs	TIGR00804	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00804
UCSC	uc002blf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002blf&org=rat
UniGene	Hs.459187	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.459187
UniProtKB	S28A1_HUMAN	http://www.uniprot.org/uniprot/S28A1_HUMAN
UniProtKB-AC	O00337	http://www.uniprot.org/uniprot/O00337
charge	swissprot:S28A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S28A1_HUMAN
eggNOG	COG1972	http://eggnogapi.embl.de/nog_data/html/tree/COG1972
eggNOG	KOG3747	http://eggnogapi.embl.de/nog_data/html/tree/KOG3747
epestfind	swissprot:S28A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S28A1_HUMAN
garnier	swissprot:S28A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S28A1_HUMAN
helixturnhelix	swissprot:S28A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S28A1_HUMAN
hmoment	swissprot:S28A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S28A1_HUMAN
iep	swissprot:S28A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S28A1_HUMAN
inforesidue	swissprot:S28A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S28A1_HUMAN
neXtProt	NX_O00337	http://www.nextprot.org/db/entry/NX_O00337
octanol	swissprot:S28A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S28A1_HUMAN
pepcoil	swissprot:S28A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S28A1_HUMAN
pepdigest	swissprot:S28A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S28A1_HUMAN
pepinfo	swissprot:S28A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S28A1_HUMAN
pepnet	swissprot:S28A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S28A1_HUMAN
pepstats	swissprot:S28A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S28A1_HUMAN
pepwheel	swissprot:S28A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S28A1_HUMAN
pepwindow	swissprot:S28A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S28A1_HUMAN
sigcleave	swissprot:S28A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S28A1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ITPR2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=Q14571-1; Sequence=Displayed; Name=Short; Synonyms=TIPR; IsoId=Q14571-2; Sequence=VSP_002699, VSP_002700; 
# AltName	ITPR2_HUMAN	IP3 receptor isoform 2
# AltName	ITPR2_HUMAN	Type 2 inositol 1,4,5-trisphosphate receptor
# BioGrid	109914	23
# CCDS	CCDS41764	-. [Q14571-1]
# ChiTaRS	ITPR2	human
# DISEASE	ITPR2_HUMAN	Anhidrosis, isolated, with normal sweat glands (ANHD) [MIM 106190]  An autosomal recessive disorder characterized by generalized, isolated anhidrosis, severe heat intolerance, and morphologically normal eccrine sweat glands. Body growth, teeth, hair, nails, and skin are normal. {ECO 0000269|PubMed 25329695}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	ITPR2_HUMAN	The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand- binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. 
# DrugBank	DB00201	Caffeine
# Ensembl	ENST00000242737	ENSP00000242737; ENSG00000123104. [Q14571-2]
# Ensembl	ENST00000381340	ENSP00000370744; ENSG00000123104. [Q14571-1]
# ExpressionAtlas	Q14571	baseline and differential
# FUNCTION	ITPR2_HUMAN	Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity). {ECO 0000250|UniProtKB Q9Z329}. 
# GO_component	GO:0005789	endoplasmic reticulum membrane; TAS:Reactome.
# GO_component	GO:0005886	plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0005938	cell cortex; IEA:Ensembl.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0030667	secretory granule membrane; IBA:GO_Central.
# GO_component	GO:0031095	platelet dense tubular network membrane; TAS:Reactome.
# GO_component	GO:0033017	sarcoplasmic reticulum membrane; IMP:BHF-UCL.
# GO_component	GO:0043235	receptor complex; IDA:MGI.
# GO_function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; TAS:ProtInc.
# GO_function	GO:0005509	calcium ion binding; IBA:GO_Central.
# GO_function	GO:0015085	calcium ion transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0035091	phosphatidylinositol binding; IBA:GO_Central.
# GO_function	GO:0070679	inositol 1,4,5 trisphosphate binding; IBA:GO_Central.
# GO_process	GO:0001666	response to hypoxia; IDA:BHF-UCL.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0030168	platelet activation; TAS:Reactome.
# GO_process	GO:0050796	regulation of insulin secretion; TAS:Reactome.
# GO_process	GO:0071320	cellular response to cAMP; IEA:Ensembl.
# GO_process	GO:0071361	cellular response to ethanol; IEA:Ensembl.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0008289	lipid binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.25.10.30	-; 2.
# Genevisible	Q14571	HS
# HGNC	HGNC:6181	ITPR2
# IntAct	Q14571	8
# InterPro	IPR000493	InsP3_rcpt-bd
# InterPro	IPR000699	RIH_dom
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR013662	RIH_assoc-dom
# InterPro	IPR014821	Ins145_P3_rcpt
# InterPro	IPR015925	Ryanodine_recept-rel
# InterPro	IPR016024	ARM-type_fold
# InterPro	IPR016093	MIR_motif
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04070	Phosphatidylinositol signaling system
# KEGG_Pathway	ko04114	Oocyte meiosis
# KEGG_Pathway	ko04270	Vascular smooth muscle contraction
# KEGG_Pathway	ko04540	Gap junction
# KEGG_Pathway	ko04720	Long-term potentiation
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04724	Glutamatergic synapse
# KEGG_Pathway	ko04725	Cholinergic synapse
# KEGG_Pathway	ko04726	Serotonergic synapse
# KEGG_Pathway	ko04728	Dopaminergic synapse
# KEGG_Pathway	ko04730	Long-term depression
# KEGG_Pathway	ko04912	GnRH signaling pathway
# KEGG_Pathway	ko04970	Salivary secretion
# KEGG_Pathway	ko04971	Gastric acid secretion
# KEGG_Pathway	ko04972	Pancreatic secretion
# KEGG_Pathway	ko05010	Alzheimer's disease
# MIM	106190	phenotype
# MIM	600144	gene
# MISCELLANEOUS	ITPR2_HUMAN	Calcium appears to inhibit ligand binding to the receptor, most probably by interacting with a distinct calcium- binding protein which then inhibits the receptor. 
# Organism	ITPR2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR13715	PTHR13715
# PRINTS	PR00779	INSP3RECEPTR
# PROSITE	PS50919	MIR; 5
# PTM	ITPR2_HUMAN	Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release. {ECO 0000250}. 
# Pfam	PF00520	Ion_trans
# Pfam	PF01365	RYDR_ITPR; 2
# Pfam	PF02815	MIR
# Pfam	PF08454	RIH_assoc
# Pfam	PF08709	Ins145_P3_rec
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-112043	PLC beta mediated events
# Reactome	R-HSA-114508	Effects of PIP2 hydrolysis
# Reactome	R-HSA-139853	Elevation of cytosolic Ca2+ levels
# Reactome	R-HSA-1489509	DAG and IP3 signaling
# Reactome	R-HSA-2029485	Role of phospholipids in phagocytosis
# Reactome	R-HSA-2871809	FCERI mediated Ca+2 mobilization
# Reactome	R-HSA-381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
# Reactome	R-HSA-4086398	Ca2+ pathway
# Reactome	R-HSA-422356	Regulation of insulin secretion
# Reactome	R-HSA-5218921	VEGFR2 mediated cell proliferation
# Reactome	R-HSA-5578775	Ion homeostasis
# Reactome	R-HSA-5607763	CLEC7A (Dectin-1) induces NFAT activation
# Reactome	R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
# RecName	ITPR2_HUMAN	Inositol 1,4,5-trisphosphate receptor type 2
# RefSeq	NP_002214	NM_002223.3. [Q14571-1]
# SIMILARITY	Belongs to the InsP3 receptor family. {ECO	0000305}. 
# SIMILARITY	Contains 5 MIR domains. {ECO:0000255|PROSITE- ProRule	PRU00131}.
# SMART	SM00472	MIR; 4
# SUBCELLULAR LOCATION	ITPR2_HUMAN	Endoplasmic reticulum membrane; Multi-pass membrane protein. 
# SUBUNIT	ITPR2_HUMAN	Homotetramer (By similarity). Interacts with CABP1 (PubMed 12032348). Interacts with BOK; regulates ITPR2 expression (By similarity). {ECO 0000250|UniProtKB P29995, ECO 0000269|PubMed 12032348}. 
# SUPFAM	SSF100909	SSF100909; 2
# SUPFAM	SSF48371	SSF48371; 3
# SUPFAM	SSF82109	SSF82109; 2
# TISSUE SPECIFICITY	ITPR2_HUMAN	Isoform Short is found in skeletal muscle and heart. 
# UCSC	uc001rhg	human. [Q14571-1]
# eggNOG	ENOG410XR97	LUCA
# eggNOG	KOG3533	Eukaryota
BLAST	swissprot:ITPR2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ITPR2_HUMAN
BioCyc	ZFISH:ENSG00000123104-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000123104-MONOMER
COXPRESdb	3709	http://coxpresdb.jp/data/gene/3709.shtml
CleanEx	HS_ITPR2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ITPR2
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1042/bj3340559	http://dx.doi.org/10.1042/bj3340559
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.102006299	http://dx.doi.org/10.1073/pnas.102006299
DOI	10.1172/JCI70720	http://dx.doi.org/10.1172/JCI70720
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DrugBank	DB00201	http://www.drugbank.ca/drugs/DB00201
EMBL	AB012610	http://www.ebi.ac.uk/ena/data/view/AB012610
EMBL	AC023051	http://www.ebi.ac.uk/ena/data/view/AC023051
EMBL	AC023425	http://www.ebi.ac.uk/ena/data/view/AC023425
EMBL	AC024093	http://www.ebi.ac.uk/ena/data/view/AC024093
EMBL	AC024145	http://www.ebi.ac.uk/ena/data/view/AC024145
EMBL	AC055720	http://www.ebi.ac.uk/ena/data/view/AC055720
EMBL	D26350	http://www.ebi.ac.uk/ena/data/view/D26350
Ensembl	ENST00000242737	http://www.ensembl.org/id/ENST00000242737
Ensembl	ENST00000381340	http://www.ensembl.org/id/ENST00000381340
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005938	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005938
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030667	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030667
GO_component	GO:0031095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031095
GO_component	GO:0033017	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033017
GO_component	GO:0043235	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043235
GO_function	GO:0005220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005220
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0015085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015085
GO_function	GO:0035091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035091
GO_function	GO:0070679	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070679
GO_process	GO:0001666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001666
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0030168	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030168
GO_process	GO:0050796	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050796
GO_process	GO:0071320	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071320
GO_process	GO:0071361	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071361
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.25.10.30	http://www.cathdb.info/version/latest/superfamily/1.25.10.30
GeneCards	ITPR2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ITPR2
GeneID	3709	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3709
GeneTree	ENSGT00760000119152	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119152
H-InvDB	HIX0036661	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0036661
HGNC	HGNC:6181	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6181
HOGENOM	HOG000007660	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007660&db=HOGENOM6
HOVERGEN	HBG052158	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052158&db=HOVERGEN
HPA	HPA059144	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA059144
InParanoid	Q14571	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q14571
IntAct	Q14571	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q14571*
InterPro	IPR000493	http://www.ebi.ac.uk/interpro/entry/IPR000493
InterPro	IPR000699	http://www.ebi.ac.uk/interpro/entry/IPR000699
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR013662	http://www.ebi.ac.uk/interpro/entry/IPR013662
InterPro	IPR014821	http://www.ebi.ac.uk/interpro/entry/IPR014821
InterPro	IPR015925	http://www.ebi.ac.uk/interpro/entry/IPR015925
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
InterPro	IPR016093	http://www.ebi.ac.uk/interpro/entry/IPR016093
Jabion	3709	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3709
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3709	http://www.genome.jp/dbget-bin/www_bget?hsa:3709
KEGG_Orthology	KO:K04959	http://www.genome.jp/dbget-bin/www_bget?KO:K04959
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04070	http://www.genome.jp/kegg-bin/show_pathway?ko04070
KEGG_Pathway	ko04114	http://www.genome.jp/kegg-bin/show_pathway?ko04114
KEGG_Pathway	ko04270	http://www.genome.jp/kegg-bin/show_pathway?ko04270
KEGG_Pathway	ko04540	http://www.genome.jp/kegg-bin/show_pathway?ko04540
KEGG_Pathway	ko04720	http://www.genome.jp/kegg-bin/show_pathway?ko04720
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
KEGG_Pathway	ko04725	http://www.genome.jp/kegg-bin/show_pathway?ko04725
KEGG_Pathway	ko04726	http://www.genome.jp/kegg-bin/show_pathway?ko04726
KEGG_Pathway	ko04728	http://www.genome.jp/kegg-bin/show_pathway?ko04728
KEGG_Pathway	ko04730	http://www.genome.jp/kegg-bin/show_pathway?ko04730
KEGG_Pathway	ko04912	http://www.genome.jp/kegg-bin/show_pathway?ko04912
KEGG_Pathway	ko04970	http://www.genome.jp/kegg-bin/show_pathway?ko04970
KEGG_Pathway	ko04971	http://www.genome.jp/kegg-bin/show_pathway?ko04971
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
MIM	106190	http://www.ncbi.nlm.nih.gov/omim/106190
MIM	600144	http://www.ncbi.nlm.nih.gov/omim/600144
MINT	MINT-157881	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-157881
OMA	SGPRFKE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SGPRFKE
OrthoDB	EOG091G00T2	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00T2
PANTHER	PTHR13715	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13715
PRINTS	PR00779	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00779
PROSITE	PS50919	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50919
PSORT	swissprot:ITPR2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ITPR2_HUMAN
PSORT-B	swissprot:ITPR2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ITPR2_HUMAN
PSORT2	swissprot:ITPR2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ITPR2_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF01365	http://pfam.xfam.org/family/PF01365
Pfam	PF02815	http://pfam.xfam.org/family/PF02815
Pfam	PF08454	http://pfam.xfam.org/family/PF08454
Pfam	PF08709	http://pfam.xfam.org/family/PF08709
PharmGKB	PA29979	http://www.pharmgkb.org/do/serve?objId=PA29979&objCls=Gene
Phobius	swissprot:ITPR2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ITPR2_HUMAN
PhylomeDB	Q14571	http://phylomedb.org/?seqid=Q14571
ProteinModelPortal	Q14571	http://www.proteinmodelportal.org/query/uniprot/Q14571
PubMed	12032348	http://www.ncbi.nlm.nih.gov/pubmed/12032348
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25329695	http://www.ncbi.nlm.nih.gov/pubmed/25329695
PubMed	8081734	http://www.ncbi.nlm.nih.gov/pubmed/8081734
PubMed	9729462	http://www.ncbi.nlm.nih.gov/pubmed/9729462
Reactome	R-HSA-112043	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112043
Reactome	R-HSA-114508	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-114508
Reactome	R-HSA-139853	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-139853
Reactome	R-HSA-1489509	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1489509
Reactome	R-HSA-2029485	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2029485
Reactome	R-HSA-2871809	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2871809
Reactome	R-HSA-381676	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-381676
Reactome	R-HSA-4086398	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-4086398
Reactome	R-HSA-422356	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-422356
Reactome	R-HSA-5218921	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5218921
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
Reactome	R-HSA-5607763	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5607763
Reactome	R-HSA-983695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983695
RefSeq	NP_002214	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002214
SMART	SM00472	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00472
STRING	9606.ENSP00000370744	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000370744&targetmode=cogs
SUPFAM	SSF100909	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF100909
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
SUPFAM	SSF82109	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82109
UCSC	uc001rhg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001rhg&org=rat
UniGene	Hs.512235	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.512235
UniProtKB	ITPR2_HUMAN	http://www.uniprot.org/uniprot/ITPR2_HUMAN
UniProtKB-AC	Q14571	http://www.uniprot.org/uniprot/Q14571
charge	swissprot:ITPR2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ITPR2_HUMAN
eggNOG	ENOG410XR97	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XR97
eggNOG	KOG3533	http://eggnogapi.embl.de/nog_data/html/tree/KOG3533
epestfind	swissprot:ITPR2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ITPR2_HUMAN
garnier	swissprot:ITPR2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ITPR2_HUMAN
helixturnhelix	swissprot:ITPR2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ITPR2_HUMAN
hmoment	swissprot:ITPR2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ITPR2_HUMAN
iep	swissprot:ITPR2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ITPR2_HUMAN
inforesidue	swissprot:ITPR2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ITPR2_HUMAN
neXtProt	NX_Q14571	http://www.nextprot.org/db/entry/NX_Q14571
octanol	swissprot:ITPR2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ITPR2_HUMAN
pepcoil	swissprot:ITPR2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ITPR2_HUMAN
pepdigest	swissprot:ITPR2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ITPR2_HUMAN
pepinfo	swissprot:ITPR2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ITPR2_HUMAN
pepnet	swissprot:ITPR2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ITPR2_HUMAN
pepstats	swissprot:ITPR2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ITPR2_HUMAN
pepwheel	swissprot:ITPR2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ITPR2_HUMAN
pepwindow	swissprot:ITPR2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ITPR2_HUMAN
sigcleave	swissprot:ITPR2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ITPR2_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCND2_HUMAN	Voltage-gated potassium channel subunit Kv4.2
# BIOPHYSICOCHEMICAL PROPERTIES	KCND2_HUMAN	Kinetic parameters  Note=Homotetrameric channels activate rapidly, i.e within a few msec. After that, they inactivate rapidly, i.e within about 50- 100 msec. The voltage-dependence of activation and inactivation and other channel characteristics vary depending on the experimental conditions, the expression system and the presence or absence of ancillary subunits. Homotetrameric channels have a unitary conductance of about 4 pS when expressed in a heterologous system. For the activation of homotetrameric channels expressed in xenopus oocytes, the voltage at half- maximal amplitude is about -10 mV. The time constant for inactivation is about 20 msec. For inactivation, the voltage at half-maximal amplitude is -62 mV. The time constant for recovery after inactivation is about 70 msec. {ECO 0000305|PubMed 11507158, ECO 0000305|PubMed 17917103}; 
# BioGrid	109953	18
# ChiTaRS	KCND2	human
# DISEASE	KCND2_HUMAN	Note=A KCND2 mutation leading to the production of a C- terminally truncated protein has been identified in a patient with epilepsy. Epilepsy is characterized by paroxysmal transient disturbances of the electrical activity of the brain that may be manifested as episodic impairment or loss of consciousness, abnormal motor phenomena, psychic or sensory disturbances, or perturbation of the autonomic nervous system. {ECO 0000269|PubMed 16934482}. 
# DISEASE	KCND2_HUMAN	Note=KNCD2 mutations have been found in a family with autism and epilepsy and may play a role in disease pathogenesis. Autism is a complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Epilepsy is characterized by paroxysmal transient disturbances of the electrical activity of the brain that may be manifested as episodic impairment or loss of consciousness, abnormal motor phenomena, psychic or sensory disturbances, or perturbation of the autonomic nervous system. {ECO 0000269|PubMed 24501278}. 
# DOMAIN	KCND2_HUMAN	The C-terminal cytoplasmic region is important for normal expression at the cell membrane and modulates the voltage- dependence of channel activation and inactivation (PubMed 16934482). It is required for interaction with KCNIP2, and probably other family members as well (By similarity). {ECO 0000250|UniProtKB Q63881, ECO 0000269|PubMed 16934482}. 
# DOMAIN	KCND2_HUMAN	The N-terminal cytoplasmic region can mediate N-type inactivation by physically blocking the channel (PubMed 14695263). This probably does not happen in vivo, where the N-terminal region mediates interaction with regulatory subunits, such as KCNIP1 and KCNIP2 (PubMed 15358149). The zinc binding sites in the N-terminal domain are important for tetramerization and assembly of a functional channel complex (By similarity). Most likely, the channel undergoes closed-state inactivation, where a subtle conformation change would render the protein less sensitive to activation. {ECO 0000250|UniProtKB Q63881, ECO 0000305|PubMed 11507158, ECO 0000305|PubMed 14695263, ECO 0000305|PubMed 15358149, ECO 0000305|PubMed 18357523}. 
# DOMAIN	KCND2_HUMAN	The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. {ECO 0000250|UniProtKB P63142}. 
# DrugBank	DB00280	Disopyramide
# DrugBank	DB00321	Amitriptyline
# DrugBank	DB00458	Imipramine
# DrugBank	DB06637	Dalfampridine
# Ensembl	ENST00000331113	ENSP00000333496; ENSG00000184408
# ExpressionAtlas	Q9NZV8	baseline and differential
# FUNCTION	KCND2_HUMAN	Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Mediates the major part of the dendritic A-type current I(SA) in brain neurons (By similarity). This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (By similarity). Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (By similarity). Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed 10551270, PubMed 15454437, PubMed 14695263, PubMed 14623880, PubMed 14980201, PubMed 16934482, PubMed 24811166, PubMed 24501278). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed 11507158). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCND2 and KCND3; channel properties depend on the type of pore-forming alpha subunits that are part of the channel. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes. Interaction with specific isoforms of the regulatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases channel activity; it modulates the kinetics of channel activation and inactivation, shifts the threshold for channel activation to more negative voltage values, shifts the threshold for inactivation to less negative voltages and accelerates recovery after inactivation (PubMed 15454437, PubMed 14623880, PubMed 14980201, PubMed 19171772, PubMed 24501278, PubMed 24811166). Likewise, interaction with DPP6 or DPP10 promotes expression at the cell membrane and regulates both channel characteristics and activity (By similarity). {ECO 0000250|UniProtKB Q63881, ECO 0000250|UniProtKB Q9Z0V2, ECO 0000269|PubMed 10551270, ECO 0000269|PubMed 10729221, ECO 0000269|PubMed 11507158, ECO 0000269|PubMed 14623880, ECO 0000269|PubMed 14695263, ECO 0000269|PubMed 14980201, ECO 0000269|PubMed 15454437, ECO 0000269|PubMed 16934482, ECO 0000269|PubMed 19171772, ECO 0000269|PubMed 24501278, ECO 0000269|PubMed 24811166}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IDA:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-SubCell.
# GO_component	GO:0031226	intrinsic component of plasma membrane; IMP:UniProtKB.
# GO_component	GO:0032809	neuronal cell body membrane; ISS:UniProtKB.
# GO_component	GO:0043197	dendritic spine; ISS:UniProtKB.
# GO_component	GO:0043204	perikaryon; IEA:UniProtKB-SubCell.
# GO_component	GO:0044853	plasma membrane raft; ISS:UniProtKB.
# GO_component	GO:0045211	postsynaptic membrane; ISS:UniProtKB.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IDA:UniProtKB.
# GO_function	GO:0005250	A-type (transient outward) potassium channel activity; IMP:UniProtKB.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0001508	action potential; TAS:UniProtKB.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:UniProtKB.
# GO_process	GO:0019228	neuronal action potential; IEA:Ensembl.
# GO_process	GO:0019233	sensory perception of pain; IEA:Ensembl.
# GO_process	GO:0045475	locomotor rhythm; IEA:Ensembl.
# GO_process	GO:0051260	protein homooligomerization; IEA:InterPro.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:0071456	cellular response to hypoxia; ISS:UniProtKB.
# GO_process	GO:0071805	potassium ion transmembrane transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.350	-; 1.
# Genevisible	Q9NZV8	HS
# HGNC	HGNC:6238	KCND2
# INTERACTION	KCND2_HUMAN	Q9NZI2 KCNIP1; NbExp=4; IntAct=EBI-1646745, EBI-2120635; Q9NS61 KCNIP2; NbExp=3; IntAct=EBI-1646745, EBI-1052975; Q9NS61-3 KCNIP2; NbExp=3; IntAct=EBI-1646745, EBI-1053010; 
# IntAct	Q9NZV8	2
# InterPro	IPR000210	BTB/POZ_dom
# InterPro	IPR003131	T1-type_BTB
# InterPro	IPR003968	K_chnl_volt-dep_Kv
# InterPro	IPR003975	K_chnl_volt-dep_Kv4
# InterPro	IPR004055	K_chnl_volt-dep_Kv4.2
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR011333	SKP1/BTB/POZ
# InterPro	IPR021645	Shal-type_N
# InterPro	IPR024587	K_chnl_volt-dep_Kv4_C
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04726	Serotonergic synapse
# MIM	605410	gene
# MISCELLANEOUS	Is specifically and reversibly inhibited by the scorpion toxin Ts8 (AC P69940). {ECO:0000250|UniProtKB	Q63881}. 
# MISCELLANEOUS	KCND2_HUMAN	The transient neuronal A-type potassium current called I(SA) is triggered at membrane potentials that are below the threshold for action potentials. It inactivates rapidly and recovers rapidly from inactivation. It regulates the firing of action potentials and plays a role in synaptic integration and plasticity. Potassium channels containing KCND2 account for about 80% of the neuronal A-type potassium current. In contrast, the potassium channel responsible for the cardiac I(to) current differs between species; it is mediated by KCND2 in rodents. In human and other non-rodents KCND3 may play an equivalent role. {ECO 0000269|PubMed 10551270, ECO 0000305|PubMed 17917103, ECO 0000305|PubMed 18357523}. 
# Organism	KCND2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11537	PTHR11537
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01491	KVCHANNEL
# PRINTS	PR01497	SHALCHANNEL
# PRINTS	PR01517	KV42CHANNEL
# PTM	KCND2_HUMAN	Phosphorylation at Ser-438 in response to MAPK activation is increased in stimulated dendrites. Interaction with KCNIP2 and DPP6 propomtes phosphorylation by PKA at Ser-552. Phosphorylation at Ser-552 has no effect on interaction with KCNIP3, but is required for the regulation of channel activity by KCNIP3. Phosphorylation at Ser-552 leads to KCND2 internalization (By similarity). Phosphorylated by MAPK in response to signaling via the metabotropic glutamate receptor GRM5 (By similarity). Phosphorylation at Ser-616 is required for the down-regulation of neuronal A-type currents in response to signaling via GRM5 (By similarity). {ECO 0000250|UniProtKB Q63881, ECO 0000250|UniProtKB Q9Z0V2}. 
# Pfam	PF00520	Ion_trans
# Pfam	PF02214	BTB_2
# Pfam	PF11601	Shal-type
# Pfam	PF11879	DUF3399
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# Reactome	R-HSA-5576894	Phase 1 - inactivation of fast Na+ channels
# RecName	KCND2_HUMAN	Potassium voltage-gated channel subfamily D member 2
# RefSeq	NP_036413	NM_012281.2
# SEQUENCE CAUTION	Sequence=BAA82996.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily. {ECO	0000305}. 
# SMART	SM00225	BTB
# SUBCELLULAR LOCATION	KCND2_HUMAN	Cell membrane {ECO 0000269|PubMed 11102480, ECO 0000269|PubMed 11507158, ECO 0000269|PubMed 14623880, ECO 0000269|PubMed 14695263, ECO 0000269|PubMed 14980201, ECO 0000269|PubMed 15454437, ECO 0000269|PubMed 16934482, ECO 0000269|PubMed 19171772, ECO 0000269|PubMed 24501278, ECO 0000269|PubMed 24811166}; Multi-pass membrane protein {ECO 0000269|PubMed 11102480, ECO 0000269|PubMed 14980201, ECO 0000305}. Cell projection, dendrite {ECO 0000269|PubMed 11102480}. Cell junction, synapse {ECO 0000250|UniProtKB Q63881}. Perikaryon {ECO 0000250|UniProtKB Q63881}. Cell junction, synapse, postsynaptic cell membrane {ECO 0000250|UniProtKB Q63881}. Cell projection, dendritic spine {ECO 0000250|UniProtKB Q63881}. Cell junction {ECO 0000250|UniProtKB Q63881}. Note=In neurons, primarily detected on dendrites, dendritic spines and on the neuron cell body, but not on axons. Localized preferentially at the dendrites of pyramidal cells in the hippocampus CA1 layer. Detected at GABAergic synapses. Detected at cell junctions that are distinct from synaptic cell contacts. Detected in lipid rafts. Detected primarily at the endoplasmic reticulum or Golgi when expressed by itself (PubMed 15454437). Interaction with KCNIP1, KCNIP2, KCNIP3 or KCNIP4 promotes expression at the cell membrane (PubMed 15454437, PubMed 24811166). Interaction with DPP6 or DPP10 promotes expression at the cell membrane (By similarity). Internalized from the cell membrane by clathrin-dependent endocytosis in response to activation of AMPA-selective glutamate receptors and PKA-mediated phosphorylation at Ser-552. Redistributed from dendritic spines to the main dendritic shaft in response to activation of AMPA-selective glutamate receptors and activation of PKA (By similarity). {ECO 0000250|UniProtKB Q63881, ECO 0000250|UniProtKB Q9Z0V2, ECO 0000269|PubMed 15454437, ECO 0000269|PubMed 24811166}. 
# SUBUNIT	KCND2_HUMAN	Homotetramer or heterotetramer with KCND1 or KCND3 (PubMed 14980201, PubMed 16934482, PubMed 24811166). Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4 (PubMed 10676964, PubMed 11287421, PubMed 11847232, PubMed 12451113, PubMed 15358149, PubMed 14623880, PubMed 14980201, PubMed 14980207, PubMed 24811166). In vivo, probably exists as heteromeric complex containing variable proportions of KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10 (PubMed 19171772). The tetrameric channel can associate with up to four regulatory subunits, such as KCNIP2 or KCNIP4 (PubMed 14623880, PubMed 14980201, PubMed 24811166). Interaction with four KCNIP4 chains does not reduce interaction with DPP10 (PubMed 24811166). Interacts with DLG4 and NCS1/FREQ (By similarity). Interacts with DLG1 (PubMed 19213956). Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2 (PubMed 15358149). Interacts with FLNA, FLNC, DPP6 and DPP10 (PubMed 11102480, PubMed 15454437, PubMed 24811166). {ECO 0000250|UniProtKB Q63881, ECO 0000250|UniProtKB Q9Z0V2, ECO 0000269|PubMed 10676964, ECO 0000269|PubMed 11102480, ECO 0000269|PubMed 11287421, ECO 0000269|PubMed 11847232, ECO 0000269|PubMed 12451113, ECO 0000269|PubMed 14623880, ECO 0000269|PubMed 14980201, ECO 0000269|PubMed 14980207, ECO 0000269|PubMed 15358149, ECO 0000269|PubMed 15454437, ECO 0000269|PubMed 16934482, ECO 0000269|PubMed 19213956, ECO 0000269|PubMed 24811166, ECO 0000305|PubMed 19171772}. 
# SUPFAM	SSF54695	SSF54695
# TCDB	1.A.1.2	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	KCND2_HUMAN	Detected in ovary, in corpus luteum and in granulosa and theca cells in the follicle (at protein level) (PubMed 15991246). Highly expressed throughout the brain (PubMed 10551270, PubMed 10729221). Detected in amygdala, caudate nucleus, cerebellum, hippocampus, substantia nigra and thalamus (PubMed 10551270, PubMed 10729221). Expression is not detectable or very low in heart, kidney, liver, lung, pancreas and skeletal muscle (PubMed 10551270, PubMed 10729221). Not detectable in human heart atrium (PubMed 12395204). {ECO 0000269|PubMed 10551270, ECO 0000269|PubMed 10729221, ECO 0000269|PubMed 12395204, ECO 0000269|PubMed 15991246}. 
# UCSC	uc003vjj	human
# eggNOG	COG1226	LUCA
# eggNOG	KOG4390	Eukaryota
BLAST	swissprot:KCND2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCND2_HUMAN
BioCyc	ZFISH:G66-31146-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31146-MONOMER
COXPRESdb	3751	http://coxpresdb.jp/data/gene/3751.shtml
CleanEx	HS_KCND2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCND2
DOI	10.1002/jcp.20453	http://dx.doi.org/10.1002/jcp.20453
DOI	10.1006/geno.2000.6117	http://dx.doi.org/10.1006/geno.2000.6117
DOI	10.1007/s00395-002-0377-4	http://dx.doi.org/10.1007/s00395-002-0377-4
DOI	10.1007/s11064-008-9650-8	http://dx.doi.org/10.1007/s11064-008-9650-8
DOI	10.1007/s12035-007-8001-0	http://dx.doi.org/10.1007/s12035-007-8001-0
DOI	10.1016/S0006-3495(04)74097-7	http://dx.doi.org/10.1016/S0006-3495(04)74097-7
DOI	10.1016/S0896-6273(04)00049-2	http://dx.doi.org/10.1016/S0896-6273(04)00049-2
DOI	10.1016/S0896-6273(04)00050-9	http://dx.doi.org/10.1016/S0896-6273(04)00050-9
DOI	10.1016/j.bbrc.2004.07.006	http://dx.doi.org/10.1016/j.bbrc.2004.07.006
DOI	10.1016/j.nbd.2006.07.001	http://dx.doi.org/10.1016/j.nbd.2006.07.001
DOI	10.1038/35000592	http://dx.doi.org/10.1038/35000592
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1074/jbc.M101320200	http://dx.doi.org/10.1074/jbc.M101320200
DOI	10.1074/jbc.M114.563452	http://dx.doi.org/10.1074/jbc.M114.563452
DOI	10.1074/jbc.M200897200	http://dx.doi.org/10.1074/jbc.M200897200
DOI	10.1074/jbc.M311332200	http://dx.doi.org/10.1074/jbc.M311332200
DOI	10.1085/jgp.200810073	http://dx.doi.org/10.1085/jgp.200810073
DOI	10.1093/dnares/6.3.197	http://dx.doi.org/10.1093/dnares/6.3.197
DOI	10.1093/hmg/ddu056	http://dx.doi.org/10.1093/hmg/ddu056
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1469-7793.2001.00065.x	http://dx.doi.org/10.1111/j.1469-7793.2001.00065.x
DOI	10.1161/CIRCRESAHA.108.191007	http://dx.doi.org/10.1161/CIRCRESAHA.108.191007
DOI	10.1529/biophysj.104.042358	http://dx.doi.org/10.1529/biophysj.104.042358
DrugBank	DB00280	http://www.drugbank.ca/drugs/DB00280
DrugBank	DB00321	http://www.drugbank.ca/drugs/DB00321
DrugBank	DB00458	http://www.drugbank.ca/drugs/DB00458
DrugBank	DB06637	http://www.drugbank.ca/drugs/DB06637
EMBL	AB028967	http://www.ebi.ac.uk/ena/data/view/AB028967
EMBL	AC004888	http://www.ebi.ac.uk/ena/data/view/AC004888
EMBL	AC004946	http://www.ebi.ac.uk/ena/data/view/AC004946
EMBL	AF121104	http://www.ebi.ac.uk/ena/data/view/AF121104
EMBL	AF142568	http://www.ebi.ac.uk/ena/data/view/AF142568
EMBL	AF166007	http://www.ebi.ac.uk/ena/data/view/AF166007
EMBL	AF166008	http://www.ebi.ac.uk/ena/data/view/AF166008
EMBL	AJ010969	http://www.ebi.ac.uk/ena/data/view/AJ010969
EMBL	BC110449	http://www.ebi.ac.uk/ena/data/view/BC110449
EMBL	BC110450	http://www.ebi.ac.uk/ena/data/view/BC110450
Ensembl	ENST00000331113	http://www.ensembl.org/id/ENST00000331113
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0031226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031226
GO_component	GO:0032809	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032809
GO_component	GO:0043197	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043197
GO_component	GO:0043204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043204
GO_component	GO:0044853	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044853
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0005250	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005250
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0001508	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001508
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0019228	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019228
GO_process	GO:0019233	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019233
GO_process	GO:0045475	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045475
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:0071456	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071456
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	KCND2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCND2
GeneID	3751	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3751
GeneTree	ENSGT00760000118846	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118846
HGNC	HGNC:6238	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6238
HOVERGEN	HBG106687	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG106687&db=HOVERGEN
HPA	HPA029068	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA029068
InParanoid	Q9NZV8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NZV8
IntAct	Q9NZV8	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NZV8*
InterPro	IPR000210	http://www.ebi.ac.uk/interpro/entry/IPR000210
InterPro	IPR003131	http://www.ebi.ac.uk/interpro/entry/IPR003131
InterPro	IPR003968	http://www.ebi.ac.uk/interpro/entry/IPR003968
InterPro	IPR003975	http://www.ebi.ac.uk/interpro/entry/IPR003975
InterPro	IPR004055	http://www.ebi.ac.uk/interpro/entry/IPR004055
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR011333	http://www.ebi.ac.uk/interpro/entry/IPR011333
InterPro	IPR021645	http://www.ebi.ac.uk/interpro/entry/IPR021645
InterPro	IPR024587	http://www.ebi.ac.uk/interpro/entry/IPR024587
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	3751	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3751
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3751	http://www.genome.jp/dbget-bin/www_bget?hsa:3751
KEGG_Orthology	KO:K04892	http://www.genome.jp/dbget-bin/www_bget?KO:K04892
KEGG_Pathway	ko04726	http://www.genome.jp/kegg-bin/show_pathway?ko04726
MIM	605410	http://www.ncbi.nlm.nih.gov/omim/605410
OMA	NYTSANQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NYTSANQ
OrthoDB	EOG091G18X0	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G18X0
PANTHER	PTHR11537	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01491	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01491
PRINTS	PR01497	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01497
PRINTS	PR01517	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01517
PSORT	swissprot:KCND2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCND2_HUMAN
PSORT-B	swissprot:KCND2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCND2_HUMAN
PSORT2	swissprot:KCND2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCND2_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF02214	http://pfam.xfam.org/family/PF02214
Pfam	PF11601	http://pfam.xfam.org/family/PF11601
Pfam	PF11879	http://pfam.xfam.org/family/PF11879
PharmGKB	PA30030	http://www.pharmgkb.org/do/serve?objId=PA30030&objCls=Gene
Phobius	swissprot:KCND2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCND2_HUMAN
PhylomeDB	Q9NZV8	http://phylomedb.org/?seqid=Q9NZV8
ProteinModelPortal	Q9NZV8	http://www.proteinmodelportal.org/query/uniprot/Q9NZV8
PubMed	10470851	http://www.ncbi.nlm.nih.gov/pubmed/10470851
PubMed	10551270	http://www.ncbi.nlm.nih.gov/pubmed/10551270
PubMed	10676964	http://www.ncbi.nlm.nih.gov/pubmed/10676964
PubMed	10729221	http://www.ncbi.nlm.nih.gov/pubmed/10729221
PubMed	11102480	http://www.ncbi.nlm.nih.gov/pubmed/11102480
PubMed	11287421	http://www.ncbi.nlm.nih.gov/pubmed/11287421
PubMed	11507158	http://www.ncbi.nlm.nih.gov/pubmed/11507158
PubMed	11847232	http://www.ncbi.nlm.nih.gov/pubmed/11847232
PubMed	12395204	http://www.ncbi.nlm.nih.gov/pubmed/12395204
PubMed	12451113	http://www.ncbi.nlm.nih.gov/pubmed/12451113
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	14623880	http://www.ncbi.nlm.nih.gov/pubmed/14623880
PubMed	14695263	http://www.ncbi.nlm.nih.gov/pubmed/14695263
PubMed	14980201	http://www.ncbi.nlm.nih.gov/pubmed/14980201
PubMed	14980207	http://www.ncbi.nlm.nih.gov/pubmed/14980207
PubMed	15358149	http://www.ncbi.nlm.nih.gov/pubmed/15358149
PubMed	15454437	http://www.ncbi.nlm.nih.gov/pubmed/15454437
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15991246	http://www.ncbi.nlm.nih.gov/pubmed/15991246
PubMed	16934482	http://www.ncbi.nlm.nih.gov/pubmed/16934482
PubMed	17917103	http://www.ncbi.nlm.nih.gov/pubmed/17917103
PubMed	18357523	http://www.ncbi.nlm.nih.gov/pubmed/18357523
PubMed	19171772	http://www.ncbi.nlm.nih.gov/pubmed/19171772
PubMed	19213956	http://www.ncbi.nlm.nih.gov/pubmed/19213956
PubMed	24501278	http://www.ncbi.nlm.nih.gov/pubmed/24501278
PubMed	24811166	http://www.ncbi.nlm.nih.gov/pubmed/24811166
PubMed	9843794	http://www.ncbi.nlm.nih.gov/pubmed/9843794
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
Reactome	R-HSA-5576894	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576894
RefSeq	NP_036413	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_036413
SMART	SM00225	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225
SMR	Q9NZV8	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9NZV8
STRING	9606.ENSP00000333496	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000333496&targetmode=cogs
SUPFAM	SSF54695	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54695
TCDB	1.A.1.2	http://www.tcdb.org/search/result.php?tc=1.A.1.2
UCSC	uc003vjj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003vjj&org=rat
UniGene	Hs.654739	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.654739
UniProtKB	KCND2_HUMAN	http://www.uniprot.org/uniprot/KCND2_HUMAN
UniProtKB-AC	Q9NZV8	http://www.uniprot.org/uniprot/Q9NZV8
charge	swissprot:KCND2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCND2_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG4390	http://eggnogapi.embl.de/nog_data/html/tree/KOG4390
epestfind	swissprot:KCND2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCND2_HUMAN
garnier	swissprot:KCND2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCND2_HUMAN
helixturnhelix	swissprot:KCND2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCND2_HUMAN
hmoment	swissprot:KCND2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCND2_HUMAN
iep	swissprot:KCND2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCND2_HUMAN
inforesidue	swissprot:KCND2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCND2_HUMAN
neXtProt	NX_Q9NZV8	http://www.nextprot.org/db/entry/NX_Q9NZV8
octanol	swissprot:KCND2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCND2_HUMAN
pepcoil	swissprot:KCND2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCND2_HUMAN
pepdigest	swissprot:KCND2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCND2_HUMAN
pepinfo	swissprot:KCND2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCND2_HUMAN
pepnet	swissprot:KCND2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCND2_HUMAN
pepstats	swissprot:KCND2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCND2_HUMAN
pepwheel	swissprot:KCND2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCND2_HUMAN
pepwindow	swissprot:KCND2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCND2_HUMAN
sigcleave	swissprot:KCND2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCND2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ATP5S_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q99766-1; Sequence=Displayed; Name=2; IsoId=Q99766-2; Sequence=VSP_040059, VSP_040062; Name=3; IsoId=Q99766-3; Sequence=VSP_040060, VSP_040061; 
# AltName	ATP5S_HUMAN	ATP synthase-coupling factor B
# AltName	ATP5S_HUMAN	Mitochondrial ATP synthase regulatory component factor B
# BioGrid	118006	15
# CAUTION	It is uncertain whether Met-1 or Met-16 is the initiator. {ECO	0000305}.
# CCDS	CCDS32075	-. [Q99766-1]
# CCDS	CCDS32076	-. [Q99766-3]
# CCDS	CCDS45102	-. [Q99766-2]
# ChiTaRS	ATP5S	human
# Ensembl	ENST00000245448	ENSP00000245448; ENSG00000125375. [Q99766-3]
# Ensembl	ENST00000311459	ENSP00000308334; ENSG00000125375. [Q99766-1]
# Ensembl	ENST00000426751	ENSP00000389246; ENSG00000125375. [Q99766-2]
# ExpressionAtlas	Q99766	baseline and differential
# FUNCTION	ATP5S_HUMAN	Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway (By similarity). {ECO 0000250}. 
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o); IEA:UniProtKB-KW.
# GO_function	GO:0015078	hydrogen ion transmembrane transporter activity; NAS:UniProtKB.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0006754	ATP biosynthetic process; TAS:Reactome.
# GO_process	GO:0015992	proton transport; NAS:UniProtKB.
# GO_process	GO:0042776	mitochondrial ATP synthesis coupled proton transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.80.10.10	-; 1.
# Genevisible	Q99766	HS
# HGNC	HGNC:18799	ATP5S
# IntAct	Q99766	12
# InterPro	IPR026063	ATP_synth_s
# InterPro	IPR032675	L_dom-like
# Organism	ATP5S_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR13382	PTHR13382
# Proteomes	UP000005640	Chromosome 14
# Reactome	R-HSA-163210	Formation of ATP by chemiosmotic coupling
# RecName	ATP5S_HUMAN	ATP synthase subunit s, mitochondrial
# RefSeq	NP_001003803	NM_001003803.2. [Q99766-1]
# RefSeq	NP_001003805	NM_001003805.2. [Q99766-3]
# RefSeq	NP_056499	NM_015684.3. [Q99766-2]
# RefSeq	XP_011534958	XM_011536656.2. [Q99766-2]
# SIMILARITY	Belongs to the ATP synthase subunit s family. {ECO	0000305}. 
# SIMILARITY	Contains 4 LRR (leucine-rich) repeats. {ECO	0000305}. 
# SUBCELLULAR LOCATION	ATP5S_HUMAN	Mitochondrion {ECO 0000250}. Mitochondrion inner membrane {ECO 0000250}. 
# SUBUNIT	Homotetramer. Associates with ATP synthase (By similarity). {ECO	0000250}. 
# UCSC	uc001wxv	human. [Q99766-1]
# eggNOG	ENOG4110375	LUCA
# eggNOG	KOG3864	Eukaryota
BLAST	swissprot:ATP5S_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ATP5S_HUMAN
BioCyc	ZFISH:HS04877-MONOMER	http://biocyc.org/getid?id=ZFISH:HS04877-MONOMER
COXPRESdb	27109	http://coxpresdb.jp/data/gene/27109.shtml
CleanEx	HS_ATP5S	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP5S
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1038/nature01348	http://dx.doi.org/10.1038/nature01348
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M111256200	http://dx.doi.org/10.1074/jbc.M111256200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AK290008	http://www.ebi.ac.uk/ena/data/view/AK290008
EMBL	AL359397	http://www.ebi.ac.uk/ena/data/view/AL359397
EMBL	AY052377	http://www.ebi.ac.uk/ena/data/view/AY052377
EMBL	BC011549	http://www.ebi.ac.uk/ena/data/view/BC011549
EMBL	CH471078	http://www.ebi.ac.uk/ena/data/view/CH471078
EMBL	CH471078	http://www.ebi.ac.uk/ena/data/view/CH471078
EMBL	U79253	http://www.ebi.ac.uk/ena/data/view/U79253
Ensembl	ENST00000245448	http://www.ensembl.org/id/ENST00000245448
Ensembl	ENST00000311459	http://www.ensembl.org/id/ENST00000311459
Ensembl	ENST00000426751	http://www.ensembl.org/id/ENST00000426751
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0045263	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045263
GO_function	GO:0015078	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015078
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006754	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006754
GO_process	GO:0015992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992
GO_process	GO:0042776	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042776
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.80.10.10	http://www.cathdb.info/version/latest/superfamily/3.80.10.10
GeneCards	ATP5S	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP5S
GeneID	27109	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27109
GeneTree	ENSGT00530000063680	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063680
HGNC	HGNC:18799	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18799
HOGENOM	HOG000230741	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230741&db=HOGENOM6
HOVERGEN	HBG050615	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050615&db=HOVERGEN
HPA	HPA046967	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA046967
HPA	HPA062690	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA062690
InParanoid	Q99766	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q99766
IntAct	Q99766	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q99766*
InterPro	IPR026063	http://www.ebi.ac.uk/interpro/entry/IPR026063
InterPro	IPR032675	http://www.ebi.ac.uk/interpro/entry/IPR032675
Jabion	27109	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=27109
KEGG_Gene	hsa:27109	http://www.genome.jp/dbget-bin/www_bget?hsa:27109
KEGG_Orthology	KO:K07554	http://www.genome.jp/dbget-bin/www_bget?KO:K07554
OMA	CDIKATK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CDIKATK
PANTHER	PTHR13382	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13382
PSORT	swissprot:ATP5S_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ATP5S_HUMAN
PSORT-B	swissprot:ATP5S_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ATP5S_HUMAN
PSORT2	swissprot:ATP5S_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ATP5S_HUMAN
Phobius	swissprot:ATP5S_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ATP5S_HUMAN
PhylomeDB	Q99766	http://phylomedb.org/?seqid=Q99766
ProteinModelPortal	Q99766	http://www.proteinmodelportal.org/query/uniprot/Q99766
PubMed	11744738	http://www.ncbi.nlm.nih.gov/pubmed/11744738
PubMed	12508121	http://www.ncbi.nlm.nih.gov/pubmed/12508121
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	9110174	http://www.ncbi.nlm.nih.gov/pubmed/9110174
Reactome	R-HSA-163210	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-163210
RefSeq	NP_001003803	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001003803
RefSeq	NP_001003805	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001003805
RefSeq	NP_056499	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_056499
RefSeq	XP_011534958	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011534958
SMR	Q99766	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q99766
STRING	9606.ENSP00000308334	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000308334&targetmode=cogs
UCSC	uc001wxv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001wxv&org=rat
UniGene	Hs.438489	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.438489
UniProtKB	ATP5S_HUMAN	http://www.uniprot.org/uniprot/ATP5S_HUMAN
UniProtKB-AC	Q99766	http://www.uniprot.org/uniprot/Q99766
charge	swissprot:ATP5S_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ATP5S_HUMAN
eggNOG	ENOG4110375	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110375
eggNOG	KOG3864	http://eggnogapi.embl.de/nog_data/html/tree/KOG3864
epestfind	swissprot:ATP5S_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ATP5S_HUMAN
garnier	swissprot:ATP5S_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ATP5S_HUMAN
helixturnhelix	swissprot:ATP5S_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATP5S_HUMAN
hmoment	swissprot:ATP5S_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ATP5S_HUMAN
iep	swissprot:ATP5S_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ATP5S_HUMAN
inforesidue	swissprot:ATP5S_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ATP5S_HUMAN
neXtProt	NX_Q99766	http://www.nextprot.org/db/entry/NX_Q99766
octanol	swissprot:ATP5S_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ATP5S_HUMAN
pepcoil	swissprot:ATP5S_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ATP5S_HUMAN
pepdigest	swissprot:ATP5S_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ATP5S_HUMAN
pepinfo	swissprot:ATP5S_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ATP5S_HUMAN
pepnet	swissprot:ATP5S_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ATP5S_HUMAN
pepstats	swissprot:ATP5S_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ATP5S_HUMAN
pepwheel	swissprot:ATP5S_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ATP5S_HUMAN
pepwindow	swissprot:ATP5S_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ATP5S_HUMAN
sigcleave	swissprot:ATP5S_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ATP5S_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TNPO3_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=2; Synonyms=TRN-SR2; IsoId=Q9Y5L0-2; Sequence=Displayed; Name=1; IsoId=Q9Y5L0-1; Sequence=VSP_030174; Name=3; IsoId=Q9Y5L0-3; Sequence=VSP_011178; Note=No experimental confirmation available.; Name=4; IsoId=Q9Y5L0-5; Sequence=VSP_045494; Note=No experimental confirmation available.; 
# AltName	TNPO3_HUMAN	Importin-12
# AltName	TNPO3_HUMAN	Transportin-SR
# BioGrid	117080	69
# CCDS	CCDS55162	-. [Q9Y5L0-5]
# CCDS	CCDS5809	-. [Q9Y5L0-2]
# ChiTaRS	TNPO3	human
# DISEASE	TNPO3_HUMAN	Limb-girdle muscular dystrophy 1F (LGMD1F) [MIM 608423]  An autosomal dominant myopathy characterized by proximal muscle weakness primarily affecting the lower limbs, but also affecting the upper limbs in most patients. Affected individuals also have distal muscle weakness of the hands and lower leg muscles. The disease has generally a benign clinical course but some individuals with childhood or juvenile onset manifest severe widespread myopathy, leading to wheelchair dependency and respiratory insufficiency. Muscle biopsy shows dystrophic changes with abnormal nuclei, rimmed vacuoles, and filamentous inclusions. {ECO 0000269|PubMed 23667635}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000265388	ENSP00000265388; ENSG00000064419. [Q9Y5L0-2]
# Ensembl	ENST00000471234	ENSP00000418646; ENSG00000064419. [Q9Y5L0-5]
# ExpressionAtlas	Q9Y5L0	baseline and differential
# FUNCTION	TNPO3_HUMAN	Seems to function in nuclear protein import as nuclear transport receptor. In vitro, mediates the nuclear import of splicing factor SR proteins RBM4, SFRS1 and SFRS2, by recognizing phosphorylated RS domains. {ECO 0000269|PubMed 10366588, ECO 0000269|PubMed 10713112, ECO 0000269|PubMed 11517331, ECO 0000269|PubMed 12628928}. 
# GO_component	GO:0005737	cytoplasm; IBA:GO_Central.
# GO_component	GO:0031965	nuclear membrane; IBA:GO_Central.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_function	GO:0004872	receptor activity; TAS:ProtInc.
# GO_function	GO:0008139	nuclear localization sequence binding; IBA:GO_Central.
# GO_function	GO:0008565	protein transporter activity; IBA:GO_Central.
# GO_function	GO:0042802	identical protein binding; IPI:IntAct.
# GO_process	GO:0035048	splicing factor protein import into nucleus; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# Gene3D	1.25.10.10	-; 3.
# Genevisible	Q9Y5L0	HS
# HGNC	HGNC:17103	TNPO3
# INTERACTION	TNPO3_HUMAN	Self; NbExp=3; IntAct=EBI-1042571, EBI-1042571; P04585 gag-pol (xeno); NbExp=6; IntAct=EBI-1042571, EBI-9872653; 
# IntAct	Q9Y5L0	29
# InterPro	IPR011989	ARM-like
# InterPro	IPR013598	Exportin-1/Importin-b-like
# InterPro	IPR016024	ARM-type_fold
# KEGG_Brite	ko03016	Transfer RNA biogenesis
# MIM	608423	phenotype
# MIM	610032	gene
# Organism	TNPO3_HUMAN	Homo sapiens (Human)
# Orphanet	186	Primary biliary cirrhosis
# Orphanet	55595	Autosomal dominant limb-girdle muscular dystrophy type 1F
# PDB	4C0O	X-ray; 2.56 A; A/B=1-923
# PDB	4C0P	X-ray; 2.95 A; A/B/C/D=1-923
# PDB	4C0Q	X-ray; 3.42 A; A/B=1-923
# PDB	4OL0	X-ray; 2.90 A; B=3-923
# Pfam	PF08389	Xpo1
# Proteomes	UP000005640	Chromosome 7
# RecName	TNPO3_HUMAN	Transportin-3
# RefSeq	NP_001177957	NM_001191028.2. [Q9Y5L0-5]
# RefSeq	NP_036602	NM_012470.3. [Q9Y5L0-2]
# SEQUENCE CAUTION	Sequence=AAD38537.1; Type=Frameshift; Positions=920; Evidence={ECO	0000305};
# SUBCELLULAR LOCATION	TNPO3_HUMAN	Cytoplasm {ECO 0000269|PubMed 10713112}. Nucleus {ECO 0000269|PubMed 10713112}. 
# SUBUNIT	TNPO3_HUMAN	Interacts with phosphorylated SFRS1 and SFRS2. Interacts with NUP62 and RBM4. {ECO 0000269|PubMed 10366588, ECO 0000269|PubMed 10713112, ECO 0000269|PubMed 11517331, ECO 0000269|PubMed 12628928}. 
# SUPFAM	SSF48371	SSF48371; 3
# TISSUE SPECIFICITY	Expressed in skeletal muscle. {ECO:0000269|PubMed	23667635}. 
# UCSC	uc003vol	human. [Q9Y5L0-2]
# eggNOG	ENOG410XRKT	LUCA
# eggNOG	KOG2081	Eukaryota
BLAST	swissprot:TNPO3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TNPO3_HUMAN
BioCyc	ZFISH:ENSG00000064419-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000064419-MONOMER
COXPRESdb	23534	http://coxpresdb.jp/data/gene/23534.shtml
CleanEx	HS_TNPO3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TNPO3
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1073/pnas.181354098	http://dx.doi.org/10.1073/pnas.181354098
DOI	10.1074/jbc.275.11.7950	http://dx.doi.org/10.1074/jbc.275.11.7950
DOI	10.1083/jcb.145.6.1145	http://dx.doi.org/10.1083/jcb.145.6.1145
DOI	10.1093/emboj/cdg126	http://dx.doi.org/10.1093/emboj/cdg126
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1083423	http://dx.doi.org/10.1126/science.1083423
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1371/journal.pone.0063536	http://dx.doi.org/10.1371/journal.pone.0063536
EMBL	AC018639	http://www.ebi.ac.uk/ena/data/view/AC018639
EMBL	AC025594	http://www.ebi.ac.uk/ena/data/view/AC025594
EMBL	AF145029	http://www.ebi.ac.uk/ena/data/view/AF145029
EMBL	AJ133769	http://www.ebi.ac.uk/ena/data/view/AJ133769
EMBL	AK225999	http://www.ebi.ac.uk/ena/data/view/AK225999
EMBL	BC009221	http://www.ebi.ac.uk/ena/data/view/BC009221
EMBL	CH236950	http://www.ebi.ac.uk/ena/data/view/CH236950
Ensembl	ENST00000265388	http://www.ensembl.org/id/ENST00000265388
Ensembl	ENST00000471234	http://www.ensembl.org/id/ENST00000471234
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0031965	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031965
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0004872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004872
GO_function	GO:0008139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008139
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0042802	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802
GO_process	GO:0035048	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035048
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
GeneCards	TNPO3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TNPO3
GeneID	23534	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23534
GeneTree	ENSGT00530000063347	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063347
HGNC	HGNC:17103	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17103
HOGENOM	HOG000273876	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273876&db=HOGENOM6
HOVERGEN	HBG057505	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG057505&db=HOVERGEN
HPA	HPA039555	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA039555
HPA	HPA041537	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA041537
InParanoid	Q9Y5L0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y5L0
IntAct	Q9Y5L0	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9Y5L0*
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR013598	http://www.ebi.ac.uk/interpro/entry/IPR013598
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
Jabion	23534	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=23534
KEGG_Brite	ko03016	http://www.genome.jp/dbget-bin/www_bget?ko03016
KEGG_Gene	hsa:23534	http://www.genome.jp/dbget-bin/www_bget?hsa:23534
KEGG_Orthology	KO:K15436	http://www.genome.jp/dbget-bin/www_bget?KO:K15436
MIM	608423	http://www.ncbi.nlm.nih.gov/omim/608423
MIM	610032	http://www.ncbi.nlm.nih.gov/omim/610032
MINT	MINT-1194798	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1194798
Orphanet	186	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=186
Orphanet	55595	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=55595
PDB	4C0O	http://www.ebi.ac.uk/pdbe-srv/view/entry/4C0O
PDB	4C0P	http://www.ebi.ac.uk/pdbe-srv/view/entry/4C0P
PDB	4C0Q	http://www.ebi.ac.uk/pdbe-srv/view/entry/4C0Q
PDB	4OL0	http://www.ebi.ac.uk/pdbe-srv/view/entry/4OL0
PDBsum	4C0O	http://www.ebi.ac.uk/pdbsum/4C0O
PDBsum	4C0P	http://www.ebi.ac.uk/pdbsum/4C0P
PDBsum	4C0Q	http://www.ebi.ac.uk/pdbsum/4C0Q
PDBsum	4OL0	http://www.ebi.ac.uk/pdbsum/4OL0
PSORT	swissprot:TNPO3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TNPO3_HUMAN
PSORT-B	swissprot:TNPO3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TNPO3_HUMAN
PSORT2	swissprot:TNPO3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TNPO3_HUMAN
Pfam	PF08389	http://pfam.xfam.org/family/PF08389
PharmGKB	PA134888159	http://www.pharmgkb.org/do/serve?objId=PA134888159&objCls=Gene
Phobius	swissprot:TNPO3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TNPO3_HUMAN
PhylomeDB	Q9Y5L0	http://phylomedb.org/?seqid=Q9Y5L0
ProteinModelPortal	Q9Y5L0	http://www.proteinmodelportal.org/query/uniprot/Q9Y5L0
PubMed	10366588	http://www.ncbi.nlm.nih.gov/pubmed/10366588
PubMed	10713112	http://www.ncbi.nlm.nih.gov/pubmed/10713112
PubMed	11517331	http://www.ncbi.nlm.nih.gov/pubmed/11517331
PubMed	12628928	http://www.ncbi.nlm.nih.gov/pubmed/12628928
PubMed	12690205	http://www.ncbi.nlm.nih.gov/pubmed/12690205
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	23667635	http://www.ncbi.nlm.nih.gov/pubmed/23667635
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
RefSeq	NP_001177957	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001177957
RefSeq	NP_036602	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_036602
SMR	Q9Y5L0	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9Y5L0
STRING	9606.ENSP00000265388	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000265388&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
UCSC	uc003vol	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003vol&org=rat
UniGene	Hs.193613	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.193613
UniProtKB	TNPO3_HUMAN	http://www.uniprot.org/uniprot/TNPO3_HUMAN
UniProtKB-AC	Q9Y5L0	http://www.uniprot.org/uniprot/Q9Y5L0
charge	swissprot:TNPO3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TNPO3_HUMAN
eggNOG	ENOG410XRKT	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRKT
eggNOG	KOG2081	http://eggnogapi.embl.de/nog_data/html/tree/KOG2081
epestfind	swissprot:TNPO3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TNPO3_HUMAN
garnier	swissprot:TNPO3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TNPO3_HUMAN
helixturnhelix	swissprot:TNPO3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TNPO3_HUMAN
hmoment	swissprot:TNPO3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TNPO3_HUMAN
iep	swissprot:TNPO3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TNPO3_HUMAN
inforesidue	swissprot:TNPO3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TNPO3_HUMAN
neXtProt	NX_Q9Y5L0	http://www.nextprot.org/db/entry/NX_Q9Y5L0
octanol	swissprot:TNPO3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TNPO3_HUMAN
pepcoil	swissprot:TNPO3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TNPO3_HUMAN
pepdigest	swissprot:TNPO3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TNPO3_HUMAN
pepinfo	swissprot:TNPO3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TNPO3_HUMAN
pepnet	swissprot:TNPO3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TNPO3_HUMAN
pepstats	swissprot:TNPO3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TNPO3_HUMAN
pepwheel	swissprot:TNPO3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TNPO3_HUMAN
pepwindow	swissprot:TNPO3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TNPO3_HUMAN
sigcleave	swissprot:TNPO3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TNPO3_HUMAN
## Database	ID	URL or Descriptions
# AltName	CXA10_HUMAN	Connexin-62
# Ensembl	ENST00000369352	ENSP00000358358; ENSG00000135355
# FUNCTION	CXA10_HUMAN	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Involved in tracer coupling between horizontal cells of the retina. May play a role in the regulation of horizontal cell patterning (By similarity). {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005922	connexin complex; IEA:InterPro.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005243	gap junction channel activity; TAS:Reactome.
# GO_process	GO:0007154	cell communication; IEA:InterPro.
# GO_process	GO:0007276	gamete generation; IEA:Ensembl.
# GO_process	GO:0007416	synapse assembly; IEA:Ensembl.
# GO_process	GO:0050908	detection of light stimulus involved in visual perception; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0022607	cellular component assembly
# Genevisible	Q969M2	HS
# HGNC	HGNC:16995	GJA10
# InterPro	IPR000500	Connexin
# InterPro	IPR013092	Connexin_N
# InterPro	IPR017990	Connexin_CS
# InterPro	IPR019570	Connexin_CCC
# MIM	611924	gene
# Organism	CXA10_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11984	PTHR11984
# PRINTS	PR00206	CONNEXIN
# PROSITE	PS00407	CONNEXINS_1
# PROSITE	PS00408	CONNEXINS_2
# Pfam	PF00029	Connexin
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-112303	Electric Transmission Across Gap Junctions
# Reactome	R-HSA-190861	Gap junction assembly
# RecName	CXA10_HUMAN	Gap junction alpha-10 protein
# RefSeq	NP_115991	NM_032602.1
# SIMILARITY	Belongs to the connexin family. Alpha-type (group II) subfamily. {ECO	0000305}.
# SMART	SM00037	CNX
# SMART	SM01089	Connexin_CCC
# SUBCELLULAR LOCATION	CXA10_HUMAN	Cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Cell junction, gap junction {ECO 0000250}. 
# SUBUNIT	A connexon is composed of a hexamer of connexins. {ECO	0000250}. 
# TISSUE SPECIFICITY	Expressed in skeletal muscle and heart. {ECO:0000269|PubMed	12881038}. 
# UCSC	uc011eaa	human
# eggNOG	ENOG410IGQJ	Eukaryota
# eggNOG	ENOG4110KSA	LUCA
BLAST	swissprot:CXA10_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CXA10_HUMAN
BioCyc	ZFISH:ENSG00000135355-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000135355-MONOMER
COXPRESdb	84694	http://coxpresdb.jp/data/gene/84694.shtml
CleanEx	HS_GJA10	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GJA10
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1080/15419060302063	http://dx.doi.org/10.1080/15419060302063
DOI	10.1515/BC.2002.076	http://dx.doi.org/10.1515/BC.2002.076
EMBL	AF296766	http://www.ebi.ac.uk/ena/data/view/AF296766
EMBL	AJ414565	http://www.ebi.ac.uk/ena/data/view/AJ414565
EMBL	AL353692	http://www.ebi.ac.uk/ena/data/view/AL353692
EMBL	CH471051	http://www.ebi.ac.uk/ena/data/view/CH471051
Ensembl	ENST00000369352	http://www.ensembl.org/id/ENST00000369352
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005922	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005922
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005243	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005243
GO_process	GO:0007154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007154
GO_process	GO:0007276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007276
GO_process	GO:0007416	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007416
GO_process	GO:0050908	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050908
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0022607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607
GeneCards	GJA10	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GJA10
GeneID	84694	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84694
GeneTree	ENSGT00840000129674	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00840000129674
HGNC	HGNC:16995	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16995
HOGENOM	HOG000231126	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231126&db=HOGENOM6
HOVERGEN	HBG009576	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG009576&db=HOVERGEN
HPA	HPA021145	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA021145
InParanoid	Q969M2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q969M2
InterPro	IPR000500	http://www.ebi.ac.uk/interpro/entry/IPR000500
InterPro	IPR013092	http://www.ebi.ac.uk/interpro/entry/IPR013092
InterPro	IPR017990	http://www.ebi.ac.uk/interpro/entry/IPR017990
InterPro	IPR019570	http://www.ebi.ac.uk/interpro/entry/IPR019570
Jabion	84694	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=84694
KEGG_Gene	hsa:84694	http://www.genome.jp/dbget-bin/www_bget?hsa:84694
KEGG_Orthology	KO:K07631	http://www.genome.jp/dbget-bin/www_bget?KO:K07631
MIM	611924	http://www.ncbi.nlm.nih.gov/omim/611924
OMA	EVHSHST	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EVHSHST
OrthoDB	EOG091G06LA	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G06LA
PANTHER	PTHR11984	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11984
PRINTS	PR00206	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00206
PROSITE	PS00407	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00407
PROSITE	PS00408	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00408
PSORT	swissprot:CXA10_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CXA10_HUMAN
PSORT-B	swissprot:CXA10_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CXA10_HUMAN
PSORT2	swissprot:CXA10_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CXA10_HUMAN
Pfam	PF00029	http://pfam.xfam.org/family/PF00029
PharmGKB	PA164741581	http://www.pharmgkb.org/do/serve?objId=PA164741581&objCls=Gene
Phobius	swissprot:CXA10_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CXA10_HUMAN
PhylomeDB	Q969M2	http://phylomedb.org/?seqid=Q969M2
ProteinModelPortal	Q969M2	http://www.proteinmodelportal.org/query/uniprot/Q969M2
PubMed	12108537	http://www.ncbi.nlm.nih.gov/pubmed/12108537
PubMed	12881038	http://www.ncbi.nlm.nih.gov/pubmed/12881038
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
Reactome	R-HSA-112303	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112303
Reactome	R-HSA-190861	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-190861
RefSeq	NP_115991	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_115991
SMART	SM00037	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00037
SMART	SM01089	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01089
STRING	9606.ENSP00000358358	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000358358&targetmode=cogs
UCSC	uc011eaa	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc011eaa&org=rat
UniGene	Hs.334499	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.334499
UniProtKB	CXA10_HUMAN	http://www.uniprot.org/uniprot/CXA10_HUMAN
UniProtKB-AC	Q969M2	http://www.uniprot.org/uniprot/Q969M2
charge	swissprot:CXA10_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CXA10_HUMAN
eggNOG	ENOG410IGQJ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IGQJ
eggNOG	ENOG4110KSA	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110KSA
epestfind	swissprot:CXA10_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CXA10_HUMAN
garnier	swissprot:CXA10_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CXA10_HUMAN
helixturnhelix	swissprot:CXA10_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CXA10_HUMAN
hmoment	swissprot:CXA10_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CXA10_HUMAN
iep	swissprot:CXA10_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CXA10_HUMAN
inforesidue	swissprot:CXA10_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CXA10_HUMAN
neXtProt	NX_Q969M2	http://www.nextprot.org/db/entry/NX_Q969M2
octanol	swissprot:CXA10_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CXA10_HUMAN
pepcoil	swissprot:CXA10_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CXA10_HUMAN
pepdigest	swissprot:CXA10_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CXA10_HUMAN
pepinfo	swissprot:CXA10_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CXA10_HUMAN
pepnet	swissprot:CXA10_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CXA10_HUMAN
pepstats	swissprot:CXA10_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CXA10_HUMAN
pepwheel	swissprot:CXA10_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CXA10_HUMAN
pepwindow	swissprot:CXA10_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CXA10_HUMAN
sigcleave	swissprot:CXA10_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CXA10_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CAC1D_HUMAN	Event=Alternative splicing; Named isoforms=4; Comment=Additional isoforms seem to exist.; Name=Neuronal-type; IsoId=Q01668-1; Sequence=Displayed; Name=Beta-cell-type; IsoId=Q01668-2; Sequence=VSP_000913, VSP_000914; Name=4; Synonyms=Ca(V)1.3(42A); IsoId=Q01668-4; Sequence=VSP_047921, VSP_047922; Note=Expressed at 5% to 15% of isoform Neuronal-type in brain tissues, increased current density.; Name=3; IsoId=Q01668-3; Sequence=VSP_046743, VSP_046744; 
# AltName	CAC1D_HUMAN	Calcium channel, L type, alpha-1 polypeptide, isoform 2
# AltName	CAC1D_HUMAN	Voltage-gated calcium channel subunit alpha Cav1.3
# CCDS	CCDS2872	-. [Q01668-2]
# CCDS	CCDS46848	-. [Q01668-1]
# CCDS	CCDS46849	-. [Q01668-3]
# ChiTaRS	CACNA1D	human
# DISEASE	CAC1D_HUMAN	Primary aldosteronism, seizures, and neurologic abnormalities (PASNA) [MIM 615474]  A disorder characterized by hypertension, hypokalemia, and high aldosterone levels with low plasma renin activity and an elevated aldosterone/renin ratio. Other features include generalized seizures, cerebral palsy, spasticity, intellectual disability, and developmental delay. {ECO 0000269|PubMed 23913001}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CAC1D_HUMAN	Sinoatrial node dysfunction and deafness (SANDD) [MIM 614896]  A disease characterized by congenital severe to profound deafness without vestibular dysfunction, associated with episodic syncope due to intermittent pronounced bradycardia. {ECO 0000269|PubMed 21131953}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	CAC1D_HUMAN	Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position. 
# DrugBank	DB00270	Isradipine
# DrugBank	DB00381	Amlodipine
# DrugBank	DB00393	Nimodipine
# DrugBank	DB00401	Nisoldipine
# DrugBank	DB00421	Spironolactone
# DrugBank	DB00568	Cinnarizine
# DrugBank	DB00622	Nicardipine
# DrugBank	DB00661	Verapamil
# DrugBank	DB00898	Ethanol
# DrugBank	DB01023	Felodipine
# DrugBank	DB01054	Nitrendipine
# DrugBank	DB01115	Nifedipine
# DrugBank	DB04855	Dronedarone
# DrugBank	DB04920	Clevidipine
# DrugBank	DB06712	Nilvadipine
# Ensembl	ENST00000288139	ENSP00000288139; ENSG00000157388. [Q01668-2]
# Ensembl	ENST00000350061	ENSP00000288133; ENSG00000157388. [Q01668-1]
# Ensembl	ENST00000422281	ENSP00000409174; ENSG00000157388. [Q01668-3]
# ExpressionAtlas	Q01668	baseline and differential
# FUNCTION	CAC1D_HUMAN	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). {ECO 0000269|PubMed 18482979}. 
# GO_component	GO:0005886	plasma membrane; ISS:BHF-UCL.
# GO_component	GO:0005891	voltage-gated calcium channel complex; IDA:UniProtKB.
# GO_component	GO:0030018	Z disc; ISS:BHF-UCL.
# GO_component	GO:1990454	L-type voltage-gated calcium channel complex; IDA:BHF-UCL.
# GO_function	GO:0005245	voltage-gated calcium channel activity; IDA:UniProtKB.
# GO_function	GO:0008331	high voltage-gated calcium channel activity; IEA:Ensembl.
# GO_function	GO:0030506	ankyrin binding; ISS:BHF-UCL.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_function	GO:0051393	alpha-actinin binding; IPI:BHF-UCL.
# GO_function	GO:0086007	voltage-gated calcium channel activity involved in cardiac muscle cell action potential; IC:BHF-UCL.
# GO_function	GO:0086059	voltage-gated calcium channel activity involved SA node cell action potential; IMP:BHF-UCL.
# GO_process	GO:0006816	calcium ion transport; IDA:UniProtKB.
# GO_process	GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway; ISS:BHF-UCL.
# GO_process	GO:0007605	sensory perception of sound; IMP:BHF-UCL.
# GO_process	GO:0050796	regulation of insulin secretion; TAS:Reactome.
# GO_process	GO:0051928	positive regulation of calcium ion transport; IDA:BHF-UCL.
# GO_process	GO:0060372	regulation of atrial cardiac muscle cell membrane repolarization; ISS:BHF-UCL.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:0070509	calcium ion import; IDA:BHF-UCL.
# GO_process	GO:0070588	calcium ion transmembrane transport; ISS:BHF-UCL.
# GO_process	GO:0086012	membrane depolarization during cardiac muscle cell action potential; IC:BHF-UCL.
# GO_process	GO:0086046	membrane depolarization during SA node cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086091	regulation of heart rate by cardiac conduction; IMP:BHF-UCL.
# GO_process	GO:1901016	regulation of potassium ion transmembrane transporter activity; ISS:BHF-UCL.
# GO_process	GO:1901379	regulation of potassium ion transmembrane transport; ISS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0008092	cytoskeletal protein binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.350	-; 5.
# Genevisible	Q01668	HS
# HGNC	HGNC:1391	CACNA1D
# InterPro	IPR002077	VDCCAlpha1
# InterPro	IPR005446	VDCC_L_a1su
# InterPro	IPR005452	LVDCC_a1dsu
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR014873	VDCC_a1su_IQ
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR031649	GPHH_dom
# InterPro	IPR031688	CAC1F_C
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H01603	[Endocrine disease] Primary aldosteronism
# KEGG_Pathway	ko04010	MAPK signaling pathway
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko04270	Vascular smooth muscle contraction
# KEGG_Pathway	ko04713	Circadian entrainment
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04724	Glutamatergic synapse
# KEGG_Pathway	ko04725	Cholinergic synapse
# KEGG_Pathway	ko04726	Serotonergic synapse
# KEGG_Pathway	ko04727	GABAergic synapse
# KEGG_Pathway	ko04728	Dopaminergic synapse
# KEGG_Pathway	ko04912	GnRH signaling pathway
# KEGG_Pathway	ko04930	Type II diabetes mellitus
# KEGG_Pathway	ko04973	Carbohydrate digestion and absorption
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05031	Amphetamine addiction
# KEGG_Pathway	ko05410	Hypertrophic cardiomyopathy (HCM)
# KEGG_Pathway	ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
# KEGG_Pathway	ko05414	Dilated cardiomyopathy
# MIM	114206	gene
# MIM	614896	phenotype
# MIM	615474	phenotype
# Organism	CAC1D_HUMAN	Homo sapiens (Human)
# Orphanet	324321	Sinoatrial node dysfunction and deafness
# Orphanet	369929	Aldosterone-producing adenoma with seizures and neurological abnormalities
# Orphanet	85142	Aldosterone-producing adenoma
# PANTHER	PTHR10037:SF139	PTHR10037:SF139
# PDB	3LV3	X-ray; 1.94 A; C=502-510
# PIR	JH0564	JH0564
# POLYMORPHISM	A change from seven to eight ATG trinucleotide repeats, resulting in an additional N-terminal methionine, has been found in a patient with non-insulin-dependent diabetes mellitus (NIDDM). {ECO:0000269|PubMed	7557998}. 
# PRINTS	PR00167	CACHANNEL
# PRINTS	PR01630	LVDCCALPHA1
# PRINTS	PR01636	LVDCCALPHA1D
# Pfam	PF00520	Ion_trans; 4
# Pfam	PF08763	Ca_chan_IQ
# Pfam	PF16885	CAC1F_C
# Pfam	PF16905	GPHH
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-400042	Adrenaline,noradrenaline inhibits insulin secretion
# Reactome	R-HSA-419037	NCAM1 interactions
# Reactome	R-HSA-422356	Regulation of insulin secretion
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# Reactome	R-HSA-5576893	Phase 2 - plateau phase
# Reactome	R-HSA-5576894	Phase 1 - inactivation of fast Na+ channels
# RecName	CAC1D_HUMAN	Voltage-dependent L-type calcium channel subunit alpha-1D
# RefSeq	NP_000711	NM_000720.3. [Q01668-2]
# RefSeq	NP_001122311	NM_001128839.2. [Q01668-3]
# RefSeq	NP_001122312	NM_001128840.2. [Q01668-1]
# SIMILARITY	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily. {ECO	0000305}.
# SMART	SM01062	Ca_chan_IQ
# SUBCELLULAR LOCATION	CAC1D_HUMAN	Membrane {ECO 0000269|PubMed 18482979}; Multi-pass membrane protein {ECO 0000269|PubMed 18482979}. 
# SUBUNIT	CAC1D_HUMAN	Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1 1 1 1 ratio. The channel activity is directed by the pore- forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Channel activity is further modulated, depending on the presence of specific delta subunit isoforms. Interacts (via IQ domain) with CABP1 and CABP4 in a calcium independent manner (By similarity). Interacts with RIMBP2 (By similarity). {ECO 0000250}. 
# TISSUE SPECIFICITY	Expressed in pancreatic islets and in brain, where it has been seen in cerebral cortex, hippocampus, basal ganglia, habenula and thalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in skeletal muscle. {ECO:0000269|PubMed	1335101}. 
# UCSC	uc003dgu	human. [Q01668-1]
# eggNOG	ENOG410XNP6	LUCA
# eggNOG	KOG2301	Eukaryota
BLAST	swissprot:CAC1D_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CAC1D_HUMAN
BioCyc	ZFISH:ENSG00000157388-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000157388-MONOMER
COXPRESdb	776	http://coxpresdb.jp/data/gene/776.shtml
CleanEx	HS_CACNA1D	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CACNA1D
DIP	DIP-48998N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48998N
DOI	10.1002/pro.559	http://dx.doi.org/10.1002/pro.559
DOI	10.1006/geno.1995.1048	http://dx.doi.org/10.1006/geno.1995.1048
DOI	10.1016/0896-6273(92)90109-Q	http://dx.doi.org/10.1016/0896-6273(92)90109-Q
DOI	10.1016/S0025-6196(12)61144-6	http://dx.doi.org/10.1016/S0025-6196(12)61144-6
DOI	10.1038/emm.1998.36	http://dx.doi.org/10.1038/emm.1998.36
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1038/ng.2695	http://dx.doi.org/10.1038/ng.2695
DOI	10.1038/nn.2694	http://dx.doi.org/10.1038/nn.2694
DOI	10.1073/pnas.89.2.584	http://dx.doi.org/10.1073/pnas.89.2.584
DOI	10.1074/jbc.M802254200	http://dx.doi.org/10.1074/jbc.M802254200
DrugBank	DB00270	http://www.drugbank.ca/drugs/DB00270
DrugBank	DB00381	http://www.drugbank.ca/drugs/DB00381
DrugBank	DB00393	http://www.drugbank.ca/drugs/DB00393
DrugBank	DB00401	http://www.drugbank.ca/drugs/DB00401
DrugBank	DB00421	http://www.drugbank.ca/drugs/DB00421
DrugBank	DB00568	http://www.drugbank.ca/drugs/DB00568
DrugBank	DB00622	http://www.drugbank.ca/drugs/DB00622
DrugBank	DB00661	http://www.drugbank.ca/drugs/DB00661
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01023	http://www.drugbank.ca/drugs/DB01023
DrugBank	DB01054	http://www.drugbank.ca/drugs/DB01054
DrugBank	DB01115	http://www.drugbank.ca/drugs/DB01115
DrugBank	DB04855	http://www.drugbank.ca/drugs/DB04855
DrugBank	DB04920	http://www.drugbank.ca/drugs/DB04920
DrugBank	DB06712	http://www.drugbank.ca/drugs/DB06712
EMBL	AC005905	http://www.ebi.ac.uk/ena/data/view/AC005905
EMBL	AC012467	http://www.ebi.ac.uk/ena/data/view/AC012467
EMBL	AC024149	http://www.ebi.ac.uk/ena/data/view/AC024149
EMBL	AC132810	http://www.ebi.ac.uk/ena/data/view/AC132810
EMBL	AF055575	http://www.ebi.ac.uk/ena/data/view/AF055575
EMBL	D43747	http://www.ebi.ac.uk/ena/data/view/D43747
EMBL	EU363339	http://www.ebi.ac.uk/ena/data/view/EU363339
EMBL	M76558	http://www.ebi.ac.uk/ena/data/view/M76558
EMBL	M83566	http://www.ebi.ac.uk/ena/data/view/M83566
Ensembl	ENST00000288139	http://www.ensembl.org/id/ENST00000288139
Ensembl	ENST00000350061	http://www.ensembl.org/id/ENST00000350061
Ensembl	ENST00000422281	http://www.ensembl.org/id/ENST00000422281
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005891
GO_component	GO:0030018	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030018
GO_component	GO:1990454	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990454
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0008331	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008331
GO_function	GO:0030506	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030506
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_function	GO:0051393	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051393
GO_function	GO:0086007	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086007
GO_function	GO:0086059	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086059
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0007188	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007188
GO_process	GO:0007605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007605
GO_process	GO:0050796	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050796
GO_process	GO:0051928	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051928
GO_process	GO:0060372	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060372
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:0070509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070509
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:0086012	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086012
GO_process	GO:0086046	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086046
GO_process	GO:0086091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086091
GO_process	GO:1901016	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901016
GO_process	GO:1901379	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901379
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0008092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	CACNA1D	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CACNA1D
GeneID	776	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=776
GeneTree	ENSGT00830000128247	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00830000128247
HGNC	HGNC:1391	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1391
HOGENOM	HOG000231529	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231529&db=HOGENOM6
HOVERGEN	HBG050763	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050763&db=HOVERGEN
HPA	HPA020215	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA020215
InParanoid	Q01668	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q01668
IntAct	Q01668	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q01668*
InterPro	IPR002077	http://www.ebi.ac.uk/interpro/entry/IPR002077
InterPro	IPR005446	http://www.ebi.ac.uk/interpro/entry/IPR005446
InterPro	IPR005452	http://www.ebi.ac.uk/interpro/entry/IPR005452
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR014873	http://www.ebi.ac.uk/interpro/entry/IPR014873
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR031649	http://www.ebi.ac.uk/interpro/entry/IPR031649
InterPro	IPR031688	http://www.ebi.ac.uk/interpro/entry/IPR031688
Jabion	776	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=776
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H01603	http://www.genome.jp/dbget-bin/www_bget?H01603
KEGG_Gene	hsa:776	http://www.genome.jp/dbget-bin/www_bget?hsa:776
KEGG_Orthology	KO:K04851	http://www.genome.jp/dbget-bin/www_bget?KO:K04851
KEGG_Pathway	ko04010	http://www.genome.jp/kegg-bin/show_pathway?ko04010
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko04270	http://www.genome.jp/kegg-bin/show_pathway?ko04270
KEGG_Pathway	ko04713	http://www.genome.jp/kegg-bin/show_pathway?ko04713
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
KEGG_Pathway	ko04725	http://www.genome.jp/kegg-bin/show_pathway?ko04725
KEGG_Pathway	ko04726	http://www.genome.jp/kegg-bin/show_pathway?ko04726
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
KEGG_Pathway	ko04728	http://www.genome.jp/kegg-bin/show_pathway?ko04728
KEGG_Pathway	ko04912	http://www.genome.jp/kegg-bin/show_pathway?ko04912
KEGG_Pathway	ko04930	http://www.genome.jp/kegg-bin/show_pathway?ko04930
KEGG_Pathway	ko04973	http://www.genome.jp/kegg-bin/show_pathway?ko04973
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05031	http://www.genome.jp/kegg-bin/show_pathway?ko05031
KEGG_Pathway	ko05410	http://www.genome.jp/kegg-bin/show_pathway?ko05410
KEGG_Pathway	ko05412	http://www.genome.jp/kegg-bin/show_pathway?ko05412
KEGG_Pathway	ko05414	http://www.genome.jp/kegg-bin/show_pathway?ko05414
MIM	114206	http://www.ncbi.nlm.nih.gov/omim/114206
MIM	614896	http://www.ncbi.nlm.nih.gov/omim/614896
MIM	615474	http://www.ncbi.nlm.nih.gov/omim/615474
OMA	IQVERPE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IQVERPE
Orphanet	324321	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=324321
Orphanet	369929	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=369929
Orphanet	85142	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=85142
OrthoDB	EOG091G0TKO	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0TKO
PANTHER	PTHR10037:SF139	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10037:SF139
PDB	3LV3	http://www.ebi.ac.uk/pdbe-srv/view/entry/3LV3
PDBsum	3LV3	http://www.ebi.ac.uk/pdbsum/3LV3
PRINTS	PR00167	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00167
PRINTS	PR01630	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01630
PRINTS	PR01636	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01636
PSORT	swissprot:CAC1D_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CAC1D_HUMAN
PSORT-B	swissprot:CAC1D_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CAC1D_HUMAN
PSORT2	swissprot:CAC1D_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CAC1D_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF08763	http://pfam.xfam.org/family/PF08763
Pfam	PF16885	http://pfam.xfam.org/family/PF16885
Pfam	PF16905	http://pfam.xfam.org/family/PF16905
PharmGKB	PA84	http://www.pharmgkb.org/do/serve?objId=PA84&objCls=Gene
Phobius	swissprot:CAC1D_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CAC1D_HUMAN
PhylomeDB	Q01668	http://phylomedb.org/?seqid=Q01668
ProteinModelPortal	Q01668	http://www.proteinmodelportal.org/query/uniprot/Q01668
PubMed	1309651	http://www.ncbi.nlm.nih.gov/pubmed/1309651
PubMed	1309948	http://www.ncbi.nlm.nih.gov/pubmed/1309948
PubMed	1335101	http://www.ncbi.nlm.nih.gov/pubmed/1335101
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	18482979	http://www.ncbi.nlm.nih.gov/pubmed/18482979
PubMed	21131953	http://www.ncbi.nlm.nih.gov/pubmed/21131953
PubMed	21280120	http://www.ncbi.nlm.nih.gov/pubmed/21280120
PubMed	23913001	http://www.ncbi.nlm.nih.gov/pubmed/23913001
PubMed	7557998	http://www.ncbi.nlm.nih.gov/pubmed/7557998
PubMed	9894156	http://www.ncbi.nlm.nih.gov/pubmed/9894156
Reactome	R-HSA-400042	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-400042
Reactome	R-HSA-419037	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-419037
Reactome	R-HSA-422356	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-422356
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
Reactome	R-HSA-5576893	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576893
Reactome	R-HSA-5576894	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576894
RefSeq	NP_000711	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000711
RefSeq	NP_001122311	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001122311
RefSeq	NP_001122312	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001122312
SMART	SM01062	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01062
SMR	Q01668	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q01668
STRING	9606.ENSP00000288139	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000288139&targetmode=cogs
UCSC	uc003dgu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003dgu&org=rat
UniGene	Hs.476358	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.476358
UniProtKB	CAC1D_HUMAN	http://www.uniprot.org/uniprot/CAC1D_HUMAN
UniProtKB-AC	Q01668	http://www.uniprot.org/uniprot/Q01668
charge	swissprot:CAC1D_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CAC1D_HUMAN
eggNOG	ENOG410XNP6	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNP6
eggNOG	KOG2301	http://eggnogapi.embl.de/nog_data/html/tree/KOG2301
epestfind	swissprot:CAC1D_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CAC1D_HUMAN
garnier	swissprot:CAC1D_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CAC1D_HUMAN
helixturnhelix	swissprot:CAC1D_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CAC1D_HUMAN
hmoment	swissprot:CAC1D_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CAC1D_HUMAN
iep	swissprot:CAC1D_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CAC1D_HUMAN
inforesidue	swissprot:CAC1D_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CAC1D_HUMAN
neXtProt	NX_Q01668	http://www.nextprot.org/db/entry/NX_Q01668
octanol	swissprot:CAC1D_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CAC1D_HUMAN
pepcoil	swissprot:CAC1D_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CAC1D_HUMAN
pepdigest	swissprot:CAC1D_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CAC1D_HUMAN
pepinfo	swissprot:CAC1D_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CAC1D_HUMAN
pepnet	swissprot:CAC1D_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CAC1D_HUMAN
pepstats	swissprot:CAC1D_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CAC1D_HUMAN
pepwheel	swissprot:CAC1D_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CAC1D_HUMAN
pepwindow	swissprot:CAC1D_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CAC1D_HUMAN
sigcleave	swissprot:CAC1D_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CAC1D_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	112232	86
# ChiTaRS	SCN2B	human
# DISEASE	SCN2B_HUMAN	Atrial fibrillation, familial, 14 (ATFB14) [MIM 615378]  A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. {ECO 0000269|PubMed 19808477}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCN2B_HUMAN	Note=Genetic variations in SCN2B may be involved in Brugada syndrome (PubMed 23559163). This tachyarrhythmia is characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset. {ECO 0000269|PubMed 23559163}. 
# DrugBank	DB00313	Valproic Acid
# DrugBank	DB00909	Zonisamide
# Ensembl	ENST00000278947	ENSP00000278947; ENSG00000149575
# ExpressionAtlas	O60939	baseline and differential
# FUNCTION	SCN2B_HUMAN	Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity). {ECO 0000250}. 
# GO_component	GO:0001518	voltage-gated sodium channel complex; TAS:UniProtKB.
# GO_function	GO:0017080	sodium channel regulator activity; IDA:BHF-UCL.
# GO_function	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential; IMP:BHF-UCL.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:ProtInc.
# GO_process	GO:0007399	nervous system development; IEA:Ensembl.
# GO_process	GO:0035725	sodium ion transmembrane transport; IDA:BHF-UCL.
# GO_process	GO:0046684	response to pyrethroid; IEA:Ensembl.
# GO_process	GO:0060048	cardiac muscle contraction; IMP:BHF-UCL.
# GO_process	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization; IMP:BHF-UCL.
# GO_process	GO:0086002	cardiac muscle cell action potential involved in contraction; IMP:BHF-UCL.
# GO_process	GO:0086012	membrane depolarization during cardiac muscle cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086091	regulation of heart rate by cardiac conduction; IMP:BHF-UCL.
# GO_process	GO:2000649	regulation of sodium ion transmembrane transporter activity; IDA:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.40.10	-; 1.
# Genevisible	O60939	HS
# HGNC	HGNC:10589	SCN2B
# InterPro	IPR000920	Myelin_P0-rel
# InterPro	IPR003599	Ig_sub
# InterPro	IPR007110	Ig-like_dom
# InterPro	IPR013106	Ig_V-set
# InterPro	IPR013783	Ig-like_fold
# InterPro	IPR029873	SCN2B
# KEGG_Brite	ko04040	Ion channels
# MIM	601327	gene
# MIM	615378	phenotype
# Organism	SCN2B_HUMAN	Homo sapiens (Human)
# Orphanet	334	Familial atrial fibrillation
# PANTHER	PTHR13869	PTHR13869
# PANTHER	PTHR13869:SF3	PTHR13869:SF3
# PDB	5FDY	X-ray; 1.85 A; A/B=30-153
# PDB	5FEB	X-ray; 1.35 A; A=30-151
# PRINTS	PR00213	MYELINP0
# PROSITE	PS50835	IG_LIKE
# Pfam	PF07686	V-set
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-445095	Interaction between L1 and Ankyrins
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# RecName	SCN2B_HUMAN	Sodium channel subunit beta-2
# RefSeq	NP_004579	NM_004588.4
# SIMILARITY	Belongs to the sodium channel auxiliary subunit SCN2B (TC 8.A.17) family. {ECO	0000305}. 
# SIMILARITY	Contains 1 Ig-like C2-type (immunoglobulin-like) domain. {ECO	0000305}.
# SMART	SM00409	IG
# SUBCELLULAR LOCATION	SCN2B_HUMAN	Membrane; Single-pass type I membrane protein. 
# SUBUNIT	The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 and beta-4 are covalently linked by disulfide bonds (By similarity). {ECO	0000250}. 
# SUPFAM	SSF48726	SSF48726
# TCDB	8.A.17.2	the na(+) channel auxiliary subunit 1-4 (sca-) family
# TISSUE SPECIFICITY	SCN2B_HUMAN	Brain specific. 
# eggNOG	ENOG410II8M	Eukaryota
# eggNOG	ENOG4111M25	LUCA
BLAST	swissprot:SCN2B_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SCN2B_HUMAN
COXPRESdb	6327	http://coxpresdb.jp/data/gene/6327.shtml
CleanEx	HS_SCN2B	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SCN2B
DOI	10.1002/humu.22328	http://dx.doi.org/10.1002/humu.22328
DOI	10.1038/sj.ejhg.5200220	http://dx.doi.org/10.1038/sj.ejhg.5200220
DOI	10.1074/jbc.M112.397646	http://dx.doi.org/10.1074/jbc.M112.397646
DOI	10.1097/00001756-199708180-00025	http://dx.doi.org/10.1097/00001756-199708180-00025
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1161/CIRCEP.108.779181	http://dx.doi.org/10.1161/CIRCEP.108.779181
DrugBank	DB00313	http://www.drugbank.ca/drugs/DB00313
DrugBank	DB00909	http://www.drugbank.ca/drugs/DB00909
EMBL	AF007783	http://www.ebi.ac.uk/ena/data/view/AF007783
EMBL	AF049496	http://www.ebi.ac.uk/ena/data/view/AF049496
EMBL	AF049497	http://www.ebi.ac.uk/ena/data/view/AF049497
EMBL	AF049498	http://www.ebi.ac.uk/ena/data/view/AF049498
EMBL	AF107028	http://www.ebi.ac.uk/ena/data/view/AF107028
EMBL	AY358945	http://www.ebi.ac.uk/ena/data/view/AY358945
EMBL	BC036793	http://www.ebi.ac.uk/ena/data/view/BC036793
EMBL	U87555	http://www.ebi.ac.uk/ena/data/view/U87555
Ensembl	ENST00000278947	http://www.ensembl.org/id/ENST00000278947
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0001518	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001518
GO_function	GO:0017080	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017080
GO_function	GO:0086006	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086006
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007399	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007399
GO_process	GO:0035725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035725
GO_process	GO:0046684	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046684
GO_process	GO:0060048	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060048
GO_process	GO:0060371	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060371
GO_process	GO:0086002	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086002
GO_process	GO:0086012	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086012
GO_process	GO:0086091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086091
GO_process	GO:2000649	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000649
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.40.10	http://www.cathdb.info/version/latest/superfamily/2.60.40.10
GeneCards	SCN2B	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SCN2B
GeneID	6327	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6327
GeneTree	ENSGT00640000091161	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00640000091161
HGNC	HGNC:10589	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10589
HOGENOM	HOG000118120	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118120&db=HOGENOM6
HOVERGEN	HBG003443	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003443&db=HOVERGEN
InParanoid	O60939	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O60939
InterPro	IPR000920	http://www.ebi.ac.uk/interpro/entry/IPR000920
InterPro	IPR003599	http://www.ebi.ac.uk/interpro/entry/IPR003599
InterPro	IPR007110	http://www.ebi.ac.uk/interpro/entry/IPR007110
InterPro	IPR013106	http://www.ebi.ac.uk/interpro/entry/IPR013106
InterPro	IPR013783	http://www.ebi.ac.uk/interpro/entry/IPR013783
InterPro	IPR029873	http://www.ebi.ac.uk/interpro/entry/IPR029873
Jabion	6327	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6327
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:6327	http://www.genome.jp/dbget-bin/www_bget?hsa:6327
KEGG_Orthology	KO:K04846	http://www.genome.jp/dbget-bin/www_bget?KO:K04846
MIM	601327	http://www.ncbi.nlm.nih.gov/omim/601327
MIM	615378	http://www.ncbi.nlm.nih.gov/omim/615378
OMA	HGKIYLQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HGKIYLQ
Orphanet	334	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=334
OrthoDB	EOG091G0O9E	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0O9E
PANTHER	PTHR13869	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13869
PANTHER	PTHR13869:SF3	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13869:SF3
PDB	5FDY	http://www.ebi.ac.uk/pdbe-srv/view/entry/5FDY
PDB	5FEB	http://www.ebi.ac.uk/pdbe-srv/view/entry/5FEB
PDBsum	5FDY	http://www.ebi.ac.uk/pdbsum/5FDY
PDBsum	5FEB	http://www.ebi.ac.uk/pdbsum/5FEB
PRINTS	PR00213	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00213
PROSITE	PS50835	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50835
PSORT	swissprot:SCN2B_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SCN2B_HUMAN
PSORT-B	swissprot:SCN2B_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SCN2B_HUMAN
PSORT2	swissprot:SCN2B_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SCN2B_HUMAN
Pfam	PF07686	http://pfam.xfam.org/family/PF07686
PharmGKB	PA303	http://www.pharmgkb.org/do/serve?objId=PA303&objCls=Gene
Phobius	swissprot:SCN2B_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SCN2B_HUMAN
PhylomeDB	O60939	http://phylomedb.org/?seqid=O60939
ProteinModelPortal	O60939	http://www.proteinmodelportal.org/query/uniprot/O60939
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19808477	http://www.ncbi.nlm.nih.gov/pubmed/19808477
PubMed	22992729	http://www.ncbi.nlm.nih.gov/pubmed/22992729
PubMed	23559163	http://www.ncbi.nlm.nih.gov/pubmed/23559163
PubMed	9295116	http://www.ncbi.nlm.nih.gov/pubmed/9295116
PubMed	9887383	http://www.ncbi.nlm.nih.gov/pubmed/9887383
Reactome	R-HSA-445095	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-445095
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
RefSeq	NP_004579	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004579
SMART	SM00409	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00409
SMR	O60939	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O60939
STRING	9606.ENSP00000278947	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000278947&targetmode=cogs
SUPFAM	SSF48726	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48726
TCDB	8.A.17.2	http://www.tcdb.org/search/result.php?tc=8.A.17.2
UniGene	Hs.129783	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.129783
UniProtKB	SCN2B_HUMAN	http://www.uniprot.org/uniprot/SCN2B_HUMAN
UniProtKB-AC	O60939	http://www.uniprot.org/uniprot/O60939
charge	swissprot:SCN2B_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SCN2B_HUMAN
eggNOG	ENOG410II8M	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410II8M
eggNOG	ENOG4111M25	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111M25
epestfind	swissprot:SCN2B_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SCN2B_HUMAN
garnier	swissprot:SCN2B_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SCN2B_HUMAN
helixturnhelix	swissprot:SCN2B_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SCN2B_HUMAN
hmoment	swissprot:SCN2B_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SCN2B_HUMAN
iep	swissprot:SCN2B_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SCN2B_HUMAN
inforesidue	swissprot:SCN2B_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SCN2B_HUMAN
neXtProt	NX_O60939	http://www.nextprot.org/db/entry/NX_O60939
octanol	swissprot:SCN2B_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SCN2B_HUMAN
pepcoil	swissprot:SCN2B_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SCN2B_HUMAN
pepdigest	swissprot:SCN2B_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SCN2B_HUMAN
pepinfo	swissprot:SCN2B_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SCN2B_HUMAN
pepnet	swissprot:SCN2B_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SCN2B_HUMAN
pepstats	swissprot:SCN2B_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SCN2B_HUMAN
pepwheel	swissprot:SCN2B_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SCN2B_HUMAN
pepwindow	swissprot:SCN2B_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SCN2B_HUMAN
sigcleave	swissprot:SCN2B_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SCN2B_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75436-1; Sequence=Displayed; Name=2; IsoId=O75436-2; Sequence=VSP_044910; Note=No experimental confirmation available. Ref.6 (BQ048905) sequence is in conflict in position: 243	G->R. {ECO:0000305}; 
# AltName	VP26A_HUMAN	Vesicle protein sorting 26A
# BioGrid	114930	99
# CCDS	CCDS41536	-. [O75436-2]
# CCDS	CCDS7286	-. [O75436-1]
# ChiTaRS	VPS26A	human
# Ensembl	ENST00000263559	ENSP00000263559; ENSG00000122958. [O75436-1]
# Ensembl	ENST00000373382	ENSP00000362480; ENSG00000122958. [O75436-1]
# Ensembl	ENST00000395098	ENSP00000378532; ENSG00000122958. [O75436-2]
# ExpressionAtlas	O75436	baseline and differential
# FUNCTION	VP26A_HUMAN	Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins (Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R (PubMed 15078902, PubMed 15078903). Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed 15247922). Required for the endosomal localization of FAM21A (indicative for the WASH complex) (PubMed 22070227). Required for the endosomal localization of TBC1D5 (PubMed 20923837). Mediates retromer cargo reognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP (PubMed 22279231). Involved in retromer- independent lysosomal sorting of F2R (PubMed 16407403). Involved in recycling of ADRB2 (PubMed 21602791). Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (By similarity). {ECO 0000250|UniProtKB P40336, ECO 0000269|PubMed 15078902, ECO 0000269|PubMed 15078903, ECO 0000269|PubMed 15247922, ECO 0000269|PubMed 16407403, ECO 0000269|PubMed 22070227, ECO 0000269|PubMed 22279231, ECO 0000303|PubMed 20923837, ECO 0000303|PubMed 21602791, ECO 0000303|PubMed 21725319, ECO 0000303|PubMed 23563491, ECO 0000305}. 
# GO_component	GO:0005768	endosome; IDA:UniProtKB.
# GO_component	GO:0005769	early endosome; IDA:UniProtKB.
# GO_component	GO:0005829	cytosol; IDA:UniProtKB.
# GO_component	GO:0010008	endosome membrane; IDA:UniProtKB.
# GO_component	GO:0030904	retromer complex; IDA:ParkinsonsUK-UCL.
# GO_component	GO:0030906	retromer, cargo-selective complex; IDA:ParkinsonsUK-UCL.
# GO_component	GO:0031982	vesicle; IDA:UniProtKB.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_component	GO:0097422	tubular endosome; IDA:UniProtKB.
# GO_function	GO:0008565	protein transporter activity; NAS:UniProtKB.
# GO_process	GO:0006886	intracellular protein transport; IBA:GO_Central.
# GO_process	GO:0016055	Wnt signaling pathway; TAS:Reactome.
# GO_process	GO:0016241	regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
# GO_process	GO:0042147	retrograde transport, endosome to Golgi; IMP:UniProtKB.
# GO_process	GO:1990126	retrograde transport, endosome to plasma membrane; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# Genevisible	O75436	HS
# HGNC	HGNC:12711	VPS26A
# INDUCTION	VP26A_HUMAN	Down-regulated in Alzheimer disease. No polymorphism or variant is however associated with Alzheimer disease for VPS26A. {ECO 0000269|PubMed 16315276, ECO 0000269|PubMed 16784798}. 
# INTERACTION	VP26A_HUMAN	Q9UBQ0 VPS29; NbExp=5; IntAct=EBI-1043891, EBI-718596; Q96QK1 VPS35; NbExp=7; IntAct=EBI-1043891, EBI-1054634; 
# IntAct	O75436	41
# InterPro	IPR028934	Vps26-related
# MIM	605506	gene
# Organism	VP26A_HUMAN	Homo sapiens (Human)
# PDB	2FAU	X-ray; 2.10 A; A=1-327
# Pfam	PF03643	Vps26
# Proteomes	UP000005640	Chromosome 10
# Reactome	R-HSA-3238698	WNT ligand biogenesis and trafficking
# RecName	VP26A_HUMAN	Vacuolar protein sorting-associated protein 26A
# RefSeq	NP_001030337	NM_001035260.2. [O75436-2]
# RefSeq	NP_001305875	NM_001318946.1
# RefSeq	NP_004887	NM_004896.4. [O75436-1]
# SIMILARITY	Belongs to the VPS26 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	VP26A_HUMAN	Cytoplasm {ECO 0000269|PubMed 15078903}. Endosome membrane {ECO 0000269|PubMed 22431521}; Peripheral membrane protein {ECO 0000250|UniProtKB P40336}. Early endosome {ECO 0000269|PubMed 15078903, ECO 0000269|PubMed 16190980, ECO 0000269|PubMed 16732284, ECO 0000269|PubMed 20682791}. Note=Localizes to tubular profiles adjacent to endosomes (PubMed 15078903). Predominantly found in early not late endosomes (By similarity). {ECO 0000250|UniProtKB P40336}. 
# SUBUNIT	VP26A_HUMAN	Component of the heterotrimeric retromer cargo-selective complex (CSC), also descibed as vacuolar protein sorting subcomplex (VPS), formed by VPS26 (VPS26A or VPS26B), VPS29 and VPS35 (PubMed 11102511). The CSC has a highly elongated structure with VPS26 and VPS29 binding independently at opposite distal ends of VPS35 as central platform (By similarity). The CSC is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants. The originally described retromer complex (also called SNX-BAR retromer) is a pentamer containing the CSC and a heterodimeric membrane-deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the respective CSC and SNX-BAR subcomplexes associate with low affinity. The CSC associates with SNX3 to form a SNX3-retromer complex. The CSC associates with SNX27, the WASH complex and the SNX-BAR subcomplex to form the SNX27-retromer complex (Probable). Interacts with VPS29, VPS35, SNX1, SNX2, SNX5, SNX6, SNX3, SNX27, RAB7A, ECM29, EHD1, KIAA0196, SORL1 (PubMed 11102511, PubMed 16190980, PubMed 19619496, PubMed 17868075, PubMed 19531583, PubMed 20682791, PubMed 20923837, PubMed 21725319, PubMed 22279231, PubMed 24344282, PubMed 16732284). {ECO 0000250|UniProtKB P40336, ECO 0000269|PubMed 11102511, ECO 0000269|PubMed 16190980, ECO 0000269|PubMed 16732284, ECO 0000269|PubMed 17868075, ECO 0000269|PubMed 19531583, ECO 0000269|PubMed 20682791, ECO 0000269|PubMed 20923837, ECO 0000269|PubMed 21725319, ECO 0000269|PubMed 22279231, ECO 0000269|PubMed 23563491, ECO 0000269|PubMed 24344282, ECO 0000303|PubMed 19619496, ECO 0000303|PubMed 21602791, ECO 0000303|PubMed 21725319}. 
# UCSC	uc001jpb	human. [O75436-1]
# eggNOG	ENOG410XSI1	LUCA
# eggNOG	KOG3063	Eukaryota
BLAST	swissprot:VP26A_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VP26A_HUMAN
BioCyc	ZFISH:ENSG00000122958-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000122958-MONOMER
COXPRESdb	9559	http://coxpresdb.jp/data/gene/9559.shtml
CleanEx	HS_VPS26A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_VPS26A
DIP	DIP-29075N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29075N
DOI	10.1002/ana.20667	http://dx.doi.org/10.1002/ana.20667
DOI	10.1016/j.devcel.2009.04.016	http://dx.doi.org/10.1016/j.devcel.2009.04.016
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.neurobiolaging.2006.05.009	http://dx.doi.org/10.1016/j.neurobiolaging.2006.05.009
DOI	10.1038/nature02462	http://dx.doi.org/10.1038/nature02462
DOI	10.1038/nbt1240	http://dx.doi.org/10.1038/nbt1240
DOI	10.1038/ncb1153	http://dx.doi.org/10.1038/ncb1153
DOI	10.1038/ncb2252	http://dx.doi.org/10.1038/ncb2252
DOI	10.1038/ncb2281	http://dx.doi.org/10.1038/ncb2281
DOI	10.1038/ncb2721	http://dx.doi.org/10.1038/ncb2721
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/nsmb1103	http://dx.doi.org/10.1038/nsmb1103
DOI	10.1042/BJ20111761	http://dx.doi.org/10.1042/BJ20111761
DOI	10.1073/pnas.1316482111	http://dx.doi.org/10.1073/pnas.1316482111
DOI	10.1073/pnas.95.14.8175	http://dx.doi.org/10.1073/pnas.95.14.8175
DOI	10.1074/jbc.M110.154120	http://dx.doi.org/10.1074/jbc.M110.154120
DOI	10.1083/jcb.200312034	http://dx.doi.org/10.1083/jcb.200312034
DOI	10.1083/jcb.200312055	http://dx.doi.org/10.1083/jcb.200312055
DOI	10.1091/mbc.11.12.4105	http://dx.doi.org/10.1091/mbc.11.12.4105
DOI	10.1091/mbc.E05-09-0899	http://dx.doi.org/10.1091/mbc.E05-09-0899
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1600-0854.2005.00328.x	http://dx.doi.org/10.1111/j.1600-0854.2005.00328.x
DOI	10.1111/j.1600-0854.2007.00652.x	http://dx.doi.org/10.1111/j.1600-0854.2007.00652.x
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1128/MCB.06726-11	http://dx.doi.org/10.1128/MCB.06726-11
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1242/jcs.048686	http://dx.doi.org/10.1242/jcs.048686
DOI	10.1242/jcs.071472	http://dx.doi.org/10.1242/jcs.071472
DOI	10.1523/JNEUROSCI.2272-11.2012	http://dx.doi.org/10.1523/JNEUROSCI.2272-11.2012
EMBL	AF054179	http://www.ebi.ac.uk/ena/data/view/AF054179
EMBL	AF175266	http://www.ebi.ac.uk/ena/data/view/AF175266
EMBL	AK022992	http://www.ebi.ac.uk/ena/data/view/AK022992
EMBL	AK315496	http://www.ebi.ac.uk/ena/data/view/AK315496
EMBL	AL442635	http://www.ebi.ac.uk/ena/data/view/AL442635
EMBL	AL442635	http://www.ebi.ac.uk/ena/data/view/AL442635
EMBL	AL596223	http://www.ebi.ac.uk/ena/data/view/AL596223
EMBL	AL596223	http://www.ebi.ac.uk/ena/data/view/AL596223
EMBL	BC022505	http://www.ebi.ac.uk/ena/data/view/BC022505
EMBL	BQ048905	http://www.ebi.ac.uk/ena/data/view/BQ048905
EMBL	CH471083	http://www.ebi.ac.uk/ena/data/view/CH471083
Ensembl	ENST00000263559	http://www.ensembl.org/id/ENST00000263559
Ensembl	ENST00000373382	http://www.ensembl.org/id/ENST00000373382
Ensembl	ENST00000395098	http://www.ensembl.org/id/ENST00000395098
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GO_component	GO:0005769	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005769
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0010008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010008
GO_component	GO:0030904	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030904
GO_component	GO:0030906	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030906
GO_component	GO:0031982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031982
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_component	GO:0097422	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097422
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0006886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006886
GO_process	GO:0016055	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016055
GO_process	GO:0016241	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016241
GO_process	GO:0042147	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042147
GO_process	GO:1990126	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990126
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GeneCards	VPS26A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=VPS26A
GeneID	9559	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9559
GeneTree	ENSGT00390000002588	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002588
HGNC	HGNC:12711	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:12711
HOGENOM	HOG000191799	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000191799&db=HOGENOM6
HOVERGEN	HBG082914	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG082914&db=HOVERGEN
HPA	CAB011602	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB011602
HPA	CAB075733	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB075733
HPA	HPA044581	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA044581
HPA	HPA057498	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA057498
InParanoid	O75436	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O75436
IntAct	O75436	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O75436*
InterPro	IPR028934	http://www.ebi.ac.uk/interpro/entry/IPR028934
Jabion	9559	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9559
KEGG_Gene	hsa:9559	http://www.genome.jp/dbget-bin/www_bget?hsa:9559
MIM	605506	http://www.ncbi.nlm.nih.gov/omim/605506
MINT	MINT-5000831	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5000831
OMA	SDKSNTH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SDKSNTH
OrthoDB	EOG091G09TQ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G09TQ
PDB	2FAU	http://www.ebi.ac.uk/pdbe-srv/view/entry/2FAU
PDBsum	2FAU	http://www.ebi.ac.uk/pdbsum/2FAU
PSORT	swissprot:VP26A_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VP26A_HUMAN
PSORT-B	swissprot:VP26A_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VP26A_HUMAN
PSORT2	swissprot:VP26A_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VP26A_HUMAN
Pfam	PF03643	http://pfam.xfam.org/family/PF03643
PharmGKB	PA37326	http://www.pharmgkb.org/do/serve?objId=PA37326&objCls=Gene
Phobius	swissprot:VP26A_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VP26A_HUMAN
PhylomeDB	O75436	http://phylomedb.org/?seqid=O75436
ProteinModelPortal	O75436	http://www.proteinmodelportal.org/query/uniprot/O75436
PubMed	11102511	http://www.ncbi.nlm.nih.gov/pubmed/11102511
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15078902	http://www.ncbi.nlm.nih.gov/pubmed/15078902
PubMed	15078903	http://www.ncbi.nlm.nih.gov/pubmed/15078903
PubMed	15164054	http://www.ncbi.nlm.nih.gov/pubmed/15164054
PubMed	15247922	http://www.ncbi.nlm.nih.gov/pubmed/15247922
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16190980	http://www.ncbi.nlm.nih.gov/pubmed/16190980
PubMed	16315276	http://www.ncbi.nlm.nih.gov/pubmed/16315276
PubMed	16407403	http://www.ncbi.nlm.nih.gov/pubmed/16407403
PubMed	16732284	http://www.ncbi.nlm.nih.gov/pubmed/16732284
PubMed	16784798	http://www.ncbi.nlm.nih.gov/pubmed/16784798
PubMed	16964243	http://www.ncbi.nlm.nih.gov/pubmed/16964243
PubMed	17868075	http://www.ncbi.nlm.nih.gov/pubmed/17868075
PubMed	19531583	http://www.ncbi.nlm.nih.gov/pubmed/19531583
PubMed	19619496	http://www.ncbi.nlm.nih.gov/pubmed/19619496
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	20682791	http://www.ncbi.nlm.nih.gov/pubmed/20682791
PubMed	20923837	http://www.ncbi.nlm.nih.gov/pubmed/20923837
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21602791	http://www.ncbi.nlm.nih.gov/pubmed/21602791
PubMed	21725319	http://www.ncbi.nlm.nih.gov/pubmed/21725319
PubMed	22070227	http://www.ncbi.nlm.nih.gov/pubmed/22070227
PubMed	22279231	http://www.ncbi.nlm.nih.gov/pubmed/22279231
PubMed	22431521	http://www.ncbi.nlm.nih.gov/pubmed/22431521
PubMed	23563491	http://www.ncbi.nlm.nih.gov/pubmed/23563491
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	24344282	http://www.ncbi.nlm.nih.gov/pubmed/24344282
PubMed	9653160	http://www.ncbi.nlm.nih.gov/pubmed/9653160
Reactome	R-HSA-3238698	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3238698
RefSeq	NP_001030337	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001030337
RefSeq	NP_001305875	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001305875
RefSeq	NP_004887	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004887
SMR	O75436	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O75436
STRING	9606.ENSP00000263559	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000263559&targetmode=cogs
UCSC	uc001jpb	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001jpb&org=rat
UniGene	Hs.499925	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.499925
UniProtKB	VP26A_HUMAN	http://www.uniprot.org/uniprot/VP26A_HUMAN
UniProtKB-AC	O75436	http://www.uniprot.org/uniprot/O75436
charge	swissprot:VP26A_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VP26A_HUMAN
eggNOG	ENOG410XSI1	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSI1
eggNOG	KOG3063	http://eggnogapi.embl.de/nog_data/html/tree/KOG3063
epestfind	swissprot:VP26A_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VP26A_HUMAN
garnier	swissprot:VP26A_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VP26A_HUMAN
helixturnhelix	swissprot:VP26A_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VP26A_HUMAN
hmoment	swissprot:VP26A_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VP26A_HUMAN
iep	swissprot:VP26A_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VP26A_HUMAN
inforesidue	swissprot:VP26A_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VP26A_HUMAN
neXtProt	NX_O75436	http://www.nextprot.org/db/entry/NX_O75436
octanol	swissprot:VP26A_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VP26A_HUMAN
pepcoil	swissprot:VP26A_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VP26A_HUMAN
pepdigest	swissprot:VP26A_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VP26A_HUMAN
pepinfo	swissprot:VP26A_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VP26A_HUMAN
pepnet	swissprot:VP26A_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VP26A_HUMAN
pepstats	swissprot:VP26A_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VP26A_HUMAN
pepwheel	swissprot:VP26A_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VP26A_HUMAN
pepwindow	swissprot:VP26A_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VP26A_HUMAN
sigcleave	swissprot:VP26A_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VP26A_HUMAN
## Database	ID	URL or Descriptions
# AltName	P2RX1_HUMAN	ATP receptor
# AltName	P2RX1_HUMAN	Purinergic receptor
# BioGrid	111062	14
# ChiTaRS	P2RX1	human
# Ensembl	ENST00000225538	ENSP00000225538; ENSG00000108405
# ExpressionAtlas	P51575	baseline and differential
# FUNCTION	P2RX1_HUMAN	Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death (By similarity). {ECO 0000250}. 
# GO_component	GO:0005639	integral component of nuclear inner membrane; IBA:GO_Central.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0031240	external side of cell outer membrane; IEA:Ensembl.
# GO_component	GO:0043005	neuron projection; IEA:Ensembl.
# GO_component	GO:0043234	protein complex; IEA:Ensembl.
# GO_component	GO:0045121	membrane raft; IEA:Ensembl.
# GO_component	GO:0045211	postsynaptic membrane; IEA:Ensembl.
# GO_function	GO:0001614	purinergic nucleotide receptor activity; IDA:MGI.
# GO_function	GO:0004931	extracellular ATP-gated cation channel activity; TAS:ProtInc.
# GO_function	GO:0005261	cation channel activity; IDA:MGI.
# GO_function	GO:0005524	ATP binding; IEA:Ensembl.
# GO_function	GO:0008144	drug binding; IEA:Ensembl.
# GO_function	GO:0008270	zinc ion binding; IEA:Ensembl.
# GO_process	GO:0002554	serotonin secretion by platelet; IEA:Ensembl.
# GO_process	GO:0003056	regulation of vascular smooth muscle contraction; IEA:Ensembl.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006811	ion transport; IDA:MGI.
# GO_process	GO:0006915	apoptotic process; IEA:UniProtKB-KW.
# GO_process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0007320	insemination; IEA:Ensembl.
# GO_process	GO:0007596	blood coagulation; TAS:Reactome.
# GO_process	GO:0008217	regulation of blood pressure; IEA:Ensembl.
# GO_process	GO:0019228	neuronal action potential; IEA:Ensembl.
# GO_process	GO:0030168	platelet activation; IEA:Ensembl.
# GO_process	GO:0033198	response to ATP; IEA:Ensembl.
# GO_process	GO:0035249	synaptic transmission, glutamatergic; IEA:Ensembl.
# GO_process	GO:0042310	vasoconstriction; IEA:Ensembl.
# GO_process	GO:0043270	positive regulation of ion transport; IEA:Ensembl.
# GO_process	GO:0046513	ceramide biosynthetic process; IEA:Ensembl.
# GO_process	GO:0051260	protein homooligomerization; IEA:Ensembl.
# GO_process	GO:0051291	protein heterooligomerization; IEA:Ensembl.
# GO_process	GO:0051924	regulation of calcium ion transport; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0003013	circulatory system process
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0008219	cell death
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# Gene3D	2.60.490.10	-; 1.
# Genevisible	P51575	HS
# HGNC	HGNC:8533	P2RX1
# InterPro	IPR001429	P2X_purnocptor
# InterPro	IPR003044	P2X1_purnocptor
# InterPro	IPR027309	P2X_extracellular_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# MIM	600845	gene+phenotype
# Organism	P2RX1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10125	PTHR10125
# PANTHER	PTHR10125:SF9	PTHR10125:SF9
# PIR	S71927	S71927
# PIRSF	PIRSF005713	P2X_purinoceptor
# PRINTS	PR01307	P2XRECEPTOR
# PRINTS	PR01308	P2X1RECEPTOR
# PROSITE	PS01212	P2X_RECEPTOR
# Pfam	PF00864	P2X_receptor
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-139853	Elevation of cytosolic Ca2+ levels
# Reactome	R-HSA-418346	Platelet homeostasis
# Reactome	R-HSA-6798695	Neutrophil degranulation
# RecName	P2RX1_HUMAN	P2X purinoceptor 1
# RefSeq	NP_002549	NM_002558.3
# SIMILARITY	Belongs to the P2X receptor family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	P2RX1_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Homo- or heteropolymers. {ECO	0000250}. 
# TIGRFAMs	TIGR00863	P2X
# UCSC	uc002fww	human
# WEB RESOURCE	P2RX1_HUMAN	Name=Wikipedia; Note=P2RX1 entry; URL="http //en.wikipedia.org/wiki/P2RX1";
# WEB RESOURCE	P2RX1_HUMAN	Name=Wikipedia; Note=P2X receptor entry; URL="https //en.wikipedia.org/wiki/P2X_receptor"; 
# eggNOG	ENOG410IFJF	Eukaryota
# eggNOG	ENOG410XR0C	LUCA
BLAST	swissprot:P2RX1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:P2RX1_HUMAN
BioCyc	ZFISH:ENSG00000108405-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000108405-MONOMER
COXPRESdb	5023	http://coxpresdb.jp/data/gene/5023.shtml
CleanEx	HS_P2RX1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_P2RX1
DOI	10.1016/0167-4781(96)00112-1	http://dx.doi.org/10.1016/0167-4781(96)00112-1
DOI	10.1074/jbc.273.19.11544	http://dx.doi.org/10.1074/jbc.273.19.11544
DOI	10.1074/jbc.C000305200	http://dx.doi.org/10.1074/jbc.C000305200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/jnc.12012	http://dx.doi.org/10.1111/jnc.12012
DOI	10.1124/mol.61.2.303	http://dx.doi.org/10.1124/mol.61.2.303
EMBL	AF020498	http://www.ebi.ac.uk/ena/data/view/AF020498
EMBL	AF177472	http://www.ebi.ac.uk/ena/data/view/AF177472
EMBL	BC044657	http://www.ebi.ac.uk/ena/data/view/BC044657
EMBL	U45448	http://www.ebi.ac.uk/ena/data/view/U45448
EMBL	X83688	http://www.ebi.ac.uk/ena/data/view/X83688
Ensembl	ENST00000225538	http://www.ensembl.org/id/ENST00000225538
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005639	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005639
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0031240	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031240
GO_component	GO:0043005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043005
GO_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GO_component	GO:0045121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045121
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0001614	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001614
GO_function	GO:0004931	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004931
GO_function	GO:0005261	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005261
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0008144	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008144
GO_function	GO:0008270	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270
GO_process	GO:0002554	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002554
GO_process	GO:0003056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003056
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006915	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006915
GO_process	GO:0006919	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006919
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007320	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007320
GO_process	GO:0007596	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007596
GO_process	GO:0008217	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008217
GO_process	GO:0019228	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019228
GO_process	GO:0030168	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030168
GO_process	GO:0033198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033198
GO_process	GO:0035249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035249
GO_process	GO:0042310	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042310
GO_process	GO:0043270	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043270
GO_process	GO:0046513	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046513
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:0051291	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051291
GO_process	GO:0051924	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051924
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0003013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003013
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0008219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
Gene3D	2.60.490.10	http://www.cathdb.info/version/latest/superfamily/2.60.490.10
GeneCards	P2RX1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=P2RX1
GeneID	5023	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5023
GeneTree	ENSGT00390000016028	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000016028
HGNC	HGNC:8533	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:8533
HOGENOM	HOG000232042	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000232042&db=HOGENOM6
HOVERGEN	HBG053086	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053086&db=HOVERGEN
HPA	CAB006813	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB006813
InParanoid	P51575	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P51575
IntAct	P51575	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P51575*
InterPro	IPR001429	http://www.ebi.ac.uk/interpro/entry/IPR001429
InterPro	IPR003044	http://www.ebi.ac.uk/interpro/entry/IPR003044
InterPro	IPR027309	http://www.ebi.ac.uk/interpro/entry/IPR027309
Jabion	5023	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=5023
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:5023	http://www.genome.jp/dbget-bin/www_bget?hsa:5023
KEGG_Orthology	KO:K05215	http://www.genome.jp/dbget-bin/www_bget?KO:K05215
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
MIM	600845	http://www.ncbi.nlm.nih.gov/omim/600845
OMA	FKYAEDM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FKYAEDM
OrthoDB	EOG091G0A2U	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0A2U
PANTHER	PTHR10125	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10125
PANTHER	PTHR10125:SF9	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10125:SF9
PRINTS	PR01307	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01307
PRINTS	PR01308	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01308
PROSITE	PS01212	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01212
PSORT	swissprot:P2RX1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:P2RX1_HUMAN
PSORT-B	swissprot:P2RX1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:P2RX1_HUMAN
PSORT2	swissprot:P2RX1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:P2RX1_HUMAN
Pfam	PF00864	http://pfam.xfam.org/family/PF00864
PharmGKB	PA32861	http://www.pharmgkb.org/do/serve?objId=PA32861&objCls=Gene
Phobius	swissprot:P2RX1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:P2RX1_HUMAN
PhylomeDB	P51575	http://phylomedb.org/?seqid=P51575
ProteinModelPortal	P51575	http://www.proteinmodelportal.org/query/uniprot/P51575
PubMed	10816552	http://www.ncbi.nlm.nih.gov/pubmed/10816552
PubMed	11809854	http://www.ncbi.nlm.nih.gov/pubmed/11809854
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	22971236	http://www.ncbi.nlm.nih.gov/pubmed/22971236
PubMed	8809107	http://www.ncbi.nlm.nih.gov/pubmed/8809107
PubMed	8834001	http://www.ncbi.nlm.nih.gov/pubmed/8834001
PubMed	9565569	http://www.ncbi.nlm.nih.gov/pubmed/9565569
Reactome	R-HSA-139853	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-139853
Reactome	R-HSA-418346	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418346
Reactome	R-HSA-6798695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6798695
RefSeq	NP_002549	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002549
SMR	P51575	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P51575
STRING	9606.ENSP00000225538	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000225538&targetmode=cogs
TIGRFAMs	TIGR00863	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00863
UCSC	uc002fww	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002fww&org=rat
UniGene	Hs.41735	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.41735
UniProtKB	P2RX1_HUMAN	http://www.uniprot.org/uniprot/P2RX1_HUMAN
UniProtKB-AC	P51575	http://www.uniprot.org/uniprot/P51575
charge	swissprot:P2RX1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:P2RX1_HUMAN
eggNOG	ENOG410IFJF	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IFJF
eggNOG	ENOG410XR0C	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XR0C
epestfind	swissprot:P2RX1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:P2RX1_HUMAN
garnier	swissprot:P2RX1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:P2RX1_HUMAN
helixturnhelix	swissprot:P2RX1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:P2RX1_HUMAN
hmoment	swissprot:P2RX1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:P2RX1_HUMAN
iep	swissprot:P2RX1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:P2RX1_HUMAN
inforesidue	swissprot:P2RX1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:P2RX1_HUMAN
neXtProt	NX_P51575	http://www.nextprot.org/db/entry/NX_P51575
octanol	swissprot:P2RX1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:P2RX1_HUMAN
pepcoil	swissprot:P2RX1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:P2RX1_HUMAN
pepdigest	swissprot:P2RX1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:P2RX1_HUMAN
pepinfo	swissprot:P2RX1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:P2RX1_HUMAN
pepnet	swissprot:P2RX1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:P2RX1_HUMAN
pepstats	swissprot:P2RX1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:P2RX1_HUMAN
pepwheel	swissprot:P2RX1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:P2RX1_HUMAN
pepwindow	swissprot:P2RX1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:P2RX1_HUMAN
sigcleave	swissprot:P2RX1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:P2RX1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ABCA7_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Type 1; IsoId=Q8IZY2-1; Sequence=Displayed; Name=2; Synonyms=Type 2; IsoId=Q8IZY2-2; Sequence=VSP_020701, VSP_020702; Note=Inactive for apoA-I-mediated lipid release.; 
# AltName	ABCA7_HUMAN	ABCA-SSN
# AltName	ABCA7_HUMAN	Autoantigen SS-N
# AltName	ABCA7_HUMAN	Macrophage ABC transporter
# BioGrid	115629	8
# CCDS	CCDS12055	-. [Q8IZY2-1]
# ChiTaRS	ABCA7	human
# DEVELOPMENTAL STAGE	ABCA7_HUMAN	Expressed in fetal tissues. Strongly expressed in fetal liver. {ECO 0000269|PubMed 10873640, ECO 0000269|PubMed 11435699}. 
# DISEASE	ABCA7_HUMAN	Alzheimer disease 9 (AD9) [MIM 608907]  A familial, late- onset form of Alzheimer disease, a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C- terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death. {ECO 0000269|PubMed 25807283, ECO 0000269|PubMed 26141617}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# Ensembl	ENST00000263094	ENSP00000263094; ENSG00000064687. [Q8IZY2-1]
# Ensembl	ENST00000433129	ENSP00000414062; ENSG00000064687. [Q8IZY2-1]
# Ensembl	ENST00000435683	ENSP00000465322; ENSG00000064687. [Q8IZY2-2]
# ExpressionAtlas	Q8IZY2	baseline and differential
# FUNCTION	ABCA7_HUMAN	Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation. {ECO 0000269|PubMed 12917409, ECO 0000269|PubMed 12925201, ECO 0000269|PubMed 14570867, ECO 0000269|PubMed 14592415}. 
# GO_component	GO:0000139	Golgi membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0001891	phagocytic cup; ISS:Alzheimers_University_of_Toronto.
# GO_component	GO:0005794	Golgi apparatus; IDA:HPA.
# GO_component	GO:0005886	plasma membrane; IDA:Alzheimers_University_of_Toronto.
# GO_component	GO:0009986	cell surface; ISS:Alzheimers_University_of_Toronto.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_component	GO:0016324	apical plasma membrane; IEA:Ensembl.
# GO_component	GO:0030054	cell junction; IDA:HPA.
# GO_component	GO:0031901	early endosome membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0032587	ruffle membrane; ISS:Alzheimers_University_of_Toronto.
# GO_component	GO:0043190	ATP-binding cassette (ABC) transporter complex; TAS:ProtInc.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IBA:GO_Central.
# GO_function	GO:0005215	transporter activity; TAS:ProtInc.
# GO_function	GO:0005524	ATP binding; TAS:ProtInc.
# GO_function	GO:0016887	ATPase activity; IDA:BHF-UCL.
# GO_function	GO:0034188	apolipoprotein A-I receptor activity; IDA:Alzheimers_University_of_Toronto.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; IBA:GO_Central.
# GO_function	GO:0090554	phosphatidylcholine-translocating ATPase activity; IDA:BHF-UCL.
# GO_function	GO:0090556	phosphatidylserine-translocating ATPase activity; IDA:BHF-UCL.
# GO_process	GO:0006909	phagocytosis; IEA:UniProtKB-KW.
# GO_process	GO:0007613	memory; ISS:Alzheimers_University_of_Toronto.
# GO_process	GO:0010875	positive regulation of cholesterol efflux; ISS:Alzheimers_University_of_Toronto.
# GO_process	GO:0018149	peptide cross-linking; ISS:Alzheimers_University_of_Toronto.
# GO_process	GO:0033344	cholesterol efflux; IDA:Alzheimers_University_of_Toronto.
# GO_process	GO:0033700	phospholipid efflux; IDA:Alzheimers_University_of_Toronto.
# GO_process	GO:0034380	high-density lipoprotein particle assembly; IDA:Alzheimers_University_of_Toronto.
# GO_process	GO:0034504	protein localization to nucleus; ISS:Alzheimers_University_of_Toronto.
# GO_process	GO:0038027	apolipoprotein A-I-mediated signaling pathway; IDA:Alzheimers_University_of_Toronto.
# GO_process	GO:0042985	negative regulation of amyloid precursor protein biosynthetic process; ISS:Alzheimers_University_of_Toronto.
# GO_process	GO:0045332	phospholipid translocation; IDA:BHF-UCL.
# GO_process	GO:0050766	positive regulation of phagocytosis; ISS:Alzheimers_University_of_Toronto.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GO_process	GO:0070374	positive regulation of ERK1 and ERK2 cascade; ISS:Alzheimers_University_of_Toronto.
# GO_process	GO:1900223	positive regulation of beta-amyloid clearance; ISS:Alzheimers_University_of_Toronto.
# GO_process	GO:1901076	positive regulation of engulfment of apoptotic cell; ISS:Alzheimers_University_of_Toronto.
# GO_process	GO:1902430	negative regulation of beta-amyloid formation; ISS:Alzheimers_University_of_Toronto.
# GO_process	GO:1902995	positive regulation of phospholipid efflux; ISS:Alzheimers_University_of_Toronto.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# GOslim_process	GO:0061024	membrane organization
# GOslim_process	GO:0065003	macromolecular complex assembly
# Gene3D	3.40.50.300	-; 2.
# Genevisible	Q8IZY2	HS
# HGNC	HGNC:37	ABCA7
# INDUCTION	ABCA7_HUMAN	Up-regulated in macrophages upon cholesterol uptake and inversely regulated upon cholesterol deloading from the cells (at protein level). Up-regulated in keratinocytes during terminal differentiation. {ECO 0000269|PubMed 10873640, ECO 0000269|PubMed 12925201}. 
# IntAct	Q8IZY2	7
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR026082	ABC_A
# InterPro	IPR027417	P-loop_NTPase
# InterPro	IPR030369	ABCA7
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko02010	ABC transporters
# MIM	605414	gene
# MIM	608907	phenotype
# Organism	ABCA7_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR19229	PTHR19229; 6
# PANTHER	PTHR19229:SF49	PTHR19229:SF49; 6
# PROSITE	PS00211	ABC_TRANSPORTER_1
# PROSITE	PS50893	ABC_TRANSPORTER_2; 2
# Pfam	PF00005	ABC_tran; 2
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-1369062	ABC transporters in lipid homeostasis
# RecName	ABCA7_HUMAN	ATP-binding cassette sub-family A member 7
# RefSeq	NP_061985	NM_019112.3. [Q8IZY2-1]
# RefSeq	XP_011525930	XM_011527628.2. [Q8IZY2-1]
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCA family. {ECO	0000305}. 
# SIMILARITY	Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA; 2
# SUBCELLULAR LOCATION	ABCA7_HUMAN	Cell membrane {ECO 0000269|PubMed 12917409, ECO 0000269|PubMed 14592415}; Multi-pass membrane protein {ECO 0000255}. Golgi apparatus membrane {ECO 0000250|UniProtKB Q91V24}; Multi-pass membrane protein {ECO 0000255}. Early endosome membrane {ECO 0000250|UniProtKB Q91V24}; Multi-pass membrane protein {ECO 0000255}. Note=Localizes to cell membrane ruffles and phagocytic cups of macrophages stimulated with C1q or apoptotic cells. Localizes to the cytoplasm of resting macrophages, probably in Golgi and endosomes. Localizes to the apical brush border of cells in the proximal tubules of kidney (By similarity). Isoform 2 may localize to the endoplasmic reticulum (PubMed 14592415). {ECO 0000250|UniProtKB Q91V24, ECO 0000269|PubMed 14592415}. 
# SUPFAM	SSF52540	SSF52540; 2
# TCDB	3.A.1.211.10	the atp-binding cassette (abc) superfamily
# TISSUE SPECIFICITY	ABCA7_HUMAN	Expressed in leukocytes (at protein level). Widely expressed. Highly expressed in myelo-lymphatic tissues including peripheral leukocytes, thymus, spleen and bone marrow. Isoform 2 is more abundant in lymph node, spleen, thymus and trachea than isoform 1 which is more strongly expressed in brain and bone marrow. {ECO 0000269|PubMed 10873640, ECO 0000269|PubMed 11435699, ECO 0000269|PubMed 14592415}. 
# UCSC	uc002lqw	human. [Q8IZY2-1]
# WEB RESOURCE	ABCA7_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=Q8IZY2";
# eggNOG	COG1131	LUCA
# eggNOG	KOG0059	Eukaryota
BLAST	swissprot:ABCA7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCA7_HUMAN
COXPRESdb	10347	http://coxpresdb.jp/data/gene/10347.shtml
CleanEx	HS_ABCA7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCA7
DOI	10.1006/bbrc.2000.2954	http://dx.doi.org/10.1006/bbrc.2000.2954
DOI	10.1006/bbrc.2000.3880	http://dx.doi.org/10.1006/bbrc.2000.3880
DOI	10.1006/bbrc.2001.4891	http://dx.doi.org/10.1006/bbrc.2001.4891
DOI	10.1007/s100380200041	http://dx.doi.org/10.1007/s100380200041
DOI	10.1016/S1474-4422(15)00133-7	http://dx.doi.org/10.1016/S1474-4422(15)00133-7
DOI	10.1016/j.bbrc.2003.10.002	http://dx.doi.org/10.1016/j.bbrc.2003.10.002
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DOI	10.1038/ng.3246	http://dx.doi.org/10.1038/ng.3246
DOI	10.1046/j.1523-1747.2003.12404.x	http://dx.doi.org/10.1046/j.1523-1747.2003.12404.x
DOI	10.1074/jbc.M307831200	http://dx.doi.org/10.1074/jbc.M307831200
DOI	10.1074/jbc.M309888200	http://dx.doi.org/10.1074/jbc.M309888200
EMBL	AB055390	http://www.ebi.ac.uk/ena/data/view/AB055390
EMBL	AC011558	http://www.ebi.ac.uk/ena/data/view/AC011558
EMBL	AF140342	http://www.ebi.ac.uk/ena/data/view/AF140342
EMBL	AF250238	http://www.ebi.ac.uk/ena/data/view/AF250238
EMBL	AF311057	http://www.ebi.ac.uk/ena/data/view/AF311057
EMBL	AF311058	http://www.ebi.ac.uk/ena/data/view/AF311058
EMBL	AF311059	http://www.ebi.ac.uk/ena/data/view/AF311059
EMBL	AF311060	http://www.ebi.ac.uk/ena/data/view/AF311060
EMBL	AF311061	http://www.ebi.ac.uk/ena/data/view/AF311061
EMBL	AF311062	http://www.ebi.ac.uk/ena/data/view/AF311062
EMBL	AF311063	http://www.ebi.ac.uk/ena/data/view/AF311063
EMBL	AF311064	http://www.ebi.ac.uk/ena/data/view/AF311064
EMBL	AF311065	http://www.ebi.ac.uk/ena/data/view/AF311065
EMBL	AF311066	http://www.ebi.ac.uk/ena/data/view/AF311066
EMBL	AF311067	http://www.ebi.ac.uk/ena/data/view/AF311067
EMBL	AF311068	http://www.ebi.ac.uk/ena/data/view/AF311068
EMBL	AF311069	http://www.ebi.ac.uk/ena/data/view/AF311069
EMBL	AF311070	http://www.ebi.ac.uk/ena/data/view/AF311070
EMBL	AF311071	http://www.ebi.ac.uk/ena/data/view/AF311071
EMBL	AF311072	http://www.ebi.ac.uk/ena/data/view/AF311072
EMBL	AF311073	http://www.ebi.ac.uk/ena/data/view/AF311073
EMBL	AF311074	http://www.ebi.ac.uk/ena/data/view/AF311074
EMBL	AF311075	http://www.ebi.ac.uk/ena/data/view/AF311075
EMBL	AF311076	http://www.ebi.ac.uk/ena/data/view/AF311076
EMBL	AF311077	http://www.ebi.ac.uk/ena/data/view/AF311077
EMBL	AF311078	http://www.ebi.ac.uk/ena/data/view/AF311078
EMBL	AF311079	http://www.ebi.ac.uk/ena/data/view/AF311079
EMBL	AF311080	http://www.ebi.ac.uk/ena/data/view/AF311080
EMBL	AF311081	http://www.ebi.ac.uk/ena/data/view/AF311081
EMBL	AF311082	http://www.ebi.ac.uk/ena/data/view/AF311082
EMBL	AF311083	http://www.ebi.ac.uk/ena/data/view/AF311083
EMBL	AF311084	http://www.ebi.ac.uk/ena/data/view/AF311084
EMBL	AF311085	http://www.ebi.ac.uk/ena/data/view/AF311085
EMBL	AF311086	http://www.ebi.ac.uk/ena/data/view/AF311086
EMBL	AF311087	http://www.ebi.ac.uk/ena/data/view/AF311087
EMBL	AF311088	http://www.ebi.ac.uk/ena/data/view/AF311088
EMBL	AF311089	http://www.ebi.ac.uk/ena/data/view/AF311089
EMBL	AF311090	http://www.ebi.ac.uk/ena/data/view/AF311090
EMBL	AF311091	http://www.ebi.ac.uk/ena/data/view/AF311091
EMBL	AF311092	http://www.ebi.ac.uk/ena/data/view/AF311092
EMBL	AF311093	http://www.ebi.ac.uk/ena/data/view/AF311093
EMBL	AF311094	http://www.ebi.ac.uk/ena/data/view/AF311094
EMBL	AF311095	http://www.ebi.ac.uk/ena/data/view/AF311095
EMBL	AF311096	http://www.ebi.ac.uk/ena/data/view/AF311096
EMBL	AF311097	http://www.ebi.ac.uk/ena/data/view/AF311097
EMBL	AF311098	http://www.ebi.ac.uk/ena/data/view/AF311098
EMBL	AF311099	http://www.ebi.ac.uk/ena/data/view/AF311099
EMBL	AF311100	http://www.ebi.ac.uk/ena/data/view/AF311100
EMBL	AF311101	http://www.ebi.ac.uk/ena/data/view/AF311101
EMBL	AF311102	http://www.ebi.ac.uk/ena/data/view/AF311102
EMBL	AF328787	http://www.ebi.ac.uk/ena/data/view/AF328787
Ensembl	ENST00000263094	http://www.ensembl.org/id/ENST00000263094
Ensembl	ENST00000433129	http://www.ensembl.org/id/ENST00000433129
Ensembl	ENST00000435683	http://www.ensembl.org/id/ENST00000435683
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0001891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001891
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0031901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031901
GO_component	GO:0032587	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032587
GO_component	GO:0043190	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GO_function	GO:0034188	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034188
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GO_function	GO:0090554	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090554
GO_function	GO:0090556	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090556
GO_process	GO:0006909	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006909
GO_process	GO:0007613	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007613
GO_process	GO:0010875	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010875
GO_process	GO:0018149	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018149
GO_process	GO:0033344	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033344
GO_process	GO:0033700	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033700
GO_process	GO:0034380	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034380
GO_process	GO:0034504	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034504
GO_process	GO:0038027	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0038027
GO_process	GO:0042985	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042985
GO_process	GO:0045332	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045332
GO_process	GO:0050766	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050766
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GO_process	GO:0070374	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070374
GO_process	GO:1900223	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900223
GO_process	GO:1901076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901076
GO_process	GO:1902430	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902430
GO_process	GO:1902995	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902995
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
GOslim_process	GO:0065003	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0065003
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCA7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCA7
GeneID	10347	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10347
GeneTree	ENSGT00760000118965	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118965
H-InvDB	HIX0014569	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0014569
HGNC	HGNC:37	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:37
HOGENOM	HOG000231547	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231547&db=HOGENOM6
HOVERGEN	HBG050436	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050436&db=HOVERGEN
HPA	HPA041564	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA041564
InParanoid	Q8IZY2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8IZY2
IntAct	Q8IZY2	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8IZY2*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR026082	http://www.ebi.ac.uk/interpro/entry/IPR026082
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
InterPro	IPR030369	http://www.ebi.ac.uk/interpro/entry/IPR030369
Jabion	10347	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10347
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:10347	http://www.genome.jp/dbget-bin/www_bget?hsa:10347
KEGG_Orthology	KO:K05645	http://www.genome.jp/dbget-bin/www_bget?KO:K05645
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
MIM	605414	http://www.ncbi.nlm.nih.gov/omim/605414
MIM	608907	http://www.ncbi.nlm.nih.gov/omim/608907
OMA	AEHGVED	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AEHGVED
OrthoDB	EOG091G007E	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G007E
PANTHER	PTHR19229	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19229
PANTHER	PTHR19229:SF49	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19229:SF49
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PSORT	swissprot:ABCA7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCA7_HUMAN
PSORT-B	swissprot:ABCA7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCA7_HUMAN
PSORT2	swissprot:ABCA7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCA7_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
PharmGKB	PA24382	http://www.pharmgkb.org/do/serve?objId=PA24382&objCls=Gene
Phobius	swissprot:ABCA7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCA7_HUMAN
PhylomeDB	Q8IZY2	http://phylomedb.org/?seqid=Q8IZY2
ProteinModelPortal	Q8IZY2	http://www.proteinmodelportal.org/query/uniprot/Q8IZY2
PubMed	10873640	http://www.ncbi.nlm.nih.gov/pubmed/10873640
PubMed	11095984	http://www.ncbi.nlm.nih.gov/pubmed/11095984
PubMed	11355874	http://www.ncbi.nlm.nih.gov/pubmed/11355874
PubMed	11435699	http://www.ncbi.nlm.nih.gov/pubmed/11435699
PubMed	12111378	http://www.ncbi.nlm.nih.gov/pubmed/12111378
PubMed	12917409	http://www.ncbi.nlm.nih.gov/pubmed/12917409
PubMed	12925201	http://www.ncbi.nlm.nih.gov/pubmed/12925201
PubMed	14570867	http://www.ncbi.nlm.nih.gov/pubmed/14570867
PubMed	14592415	http://www.ncbi.nlm.nih.gov/pubmed/14592415
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	25807283	http://www.ncbi.nlm.nih.gov/pubmed/25807283
PubMed	26141617	http://www.ncbi.nlm.nih.gov/pubmed/26141617
Reactome	R-HSA-1369062	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1369062
RefSeq	NP_061985	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061985
RefSeq	XP_011525930	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011525930
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	Q8IZY2	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8IZY2
STRING	9606.ENSP00000263094	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000263094&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TCDB	3.A.1.211.10	http://www.tcdb.org/search/result.php?tc=3.A.1.211.10
UCSC	uc002lqw	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002lqw&org=rat
UniGene	Hs.134514	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.134514
UniProtKB	ABCA7_HUMAN	http://www.uniprot.org/uniprot/ABCA7_HUMAN
UniProtKB-AC	Q8IZY2	http://www.uniprot.org/uniprot/Q8IZY2
charge	swissprot:ABCA7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCA7_HUMAN
eggNOG	COG1131	http://eggnogapi.embl.de/nog_data/html/tree/COG1131
eggNOG	KOG0059	http://eggnogapi.embl.de/nog_data/html/tree/KOG0059
epestfind	swissprot:ABCA7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCA7_HUMAN
garnier	swissprot:ABCA7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCA7_HUMAN
helixturnhelix	swissprot:ABCA7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCA7_HUMAN
hmoment	swissprot:ABCA7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCA7_HUMAN
iep	swissprot:ABCA7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCA7_HUMAN
inforesidue	swissprot:ABCA7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCA7_HUMAN
neXtProt	NX_Q8IZY2	http://www.nextprot.org/db/entry/NX_Q8IZY2
octanol	swissprot:ABCA7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCA7_HUMAN
pepcoil	swissprot:ABCA7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCA7_HUMAN
pepdigest	swissprot:ABCA7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCA7_HUMAN
pepinfo	swissprot:ABCA7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCA7_HUMAN
pepnet	swissprot:ABCA7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCA7_HUMAN
pepstats	swissprot:ABCA7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCA7_HUMAN
pepwheel	swissprot:ABCA7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCA7_HUMAN
pepwindow	swissprot:ABCA7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCA7_HUMAN
sigcleave	swissprot:ABCA7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCA7_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	LAT2_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9UHI5-1; Sequence=Displayed; Name=2; IsoId=Q9UHI5-2; Sequence=VSP_046946; Note=No experimental confirmation available.; Name=3; IsoId=Q9UHI5-3; Sequence=VSP_046945; Note=No experimental confirmation available.; Name=4; IsoId=Q9UHI5-4; Sequence=VSP_046947; Note=No experimental confirmation available.; 
# AltName	LAT2_HUMAN	L-type amino acid transporter 2
# AltName	LAT2_HUMAN	Solute carrier family 7 member 8
# BIOPHYSICOCHEMICAL PROPERTIES	LAT2_HUMAN	Kinetic parameters  KM=221 uM for L-leucine {ECO 0000269|PubMed 10391915, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 15081149, ECO 0000269|PubMed 15918515}; KM=64 uM for MeHg-L-cysteine {ECO 0000269|PubMed 10391915, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 15081149, ECO 0000269|PubMed 15918515}; KM=161 uM for methionine {ECO 0000269|PubMed 10391915, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 15081149, ECO 0000269|PubMed 15918515}; KM=978 uM for L-alanine {ECO 0000269|PubMed 10391915, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 15081149, ECO 0000269|PubMed 15918515}; KM=89.35 uM for L-phenylalanine {ECO 0000269|PubMed 10391915, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 15081149, ECO 0000269|PubMed 15918515}; KM=57.3 uM for L-tryptophan {ECO 0000269|PubMed 10391915, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 15081149, ECO 0000269|PubMed 15918515}; KM=48.8 uM for L-tyrosine {ECO 0000269|PubMed 10391915, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 15081149, ECO 0000269|PubMed 15918515}; 
# CCDS	CCDS41924	-. [Q9UHI5-2]
# CCDS	CCDS58304	-. [Q9UHI5-3]
# CCDS	CCDS58305	-. [Q9UHI5-4]
# CCDS	CCDS9590	-. [Q9UHI5-1]
# ChiTaRS	SLC7A8	human
# DrugBank	DB00120	L-Phenylalanine
# DrugBank	DB00130	L-Glutamine
# DrugBank	DB00160	L-Alanine
# DrugBank	DB01235	Levodopa
# Ensembl	ENST00000316902	ENSP00000320378; ENSG00000092068. [Q9UHI5-1]
# Ensembl	ENST00000422941	ENSP00000416398; ENSG00000092068. [Q9UHI5-3]
# Ensembl	ENST00000453702	ENSP00000391577; ENSG00000092068. [Q9UHI5-2]
# Ensembl	ENST00000529705	ENSP00000434345; ENSG00000092068. [Q9UHI5-4]
# ExpressionAtlas	Q9UHI5	baseline and differential
# FUNCTION	LAT2_HUMAN	Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney. {ECO 0000269|PubMed 10391915, ECO 0000269|PubMed 10574970, ECO 0000269|PubMed 11311135, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 12716892, ECO 0000269|PubMed 15081149, ECO 0000269|PubMed 15769744, ECO 0000269|PubMed 15918515}. 
# GO_component	GO:0005737	cytoplasm; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0015101	organic cation transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015175	neutral amino acid transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0015179	L-amino acid transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015297	antiporter activity; IBA:GO_Central.
# GO_function	GO:0019534	toxin transporter activity; IDA:UniProtKB.
# GO_function	GO:0042605	peptide antigen binding; ISS:UniProtKB.
# GO_process	GO:0006520	cellular amino acid metabolic process; TAS:ProtInc.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006865	amino acid transport; IDA:UniProtKB.
# GO_process	GO:0009636	response to toxic substance; NAS:UniProtKB.
# GO_process	GO:0015804	neutral amino acid transport; ISS:UniProtKB.
# GO_process	GO:0050900	leukocyte migration; TAS:Reactome.
# GO_process	GO:0055065	metal ion homeostasis; NAS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006520	cellular amino acid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048870	cell motility
# Genevisible	Q9UHI5	HS
# HGNC	HGNC:11066	SLC7A8
# INDUCTION	Activity in polarized intestinal cells is regulated by the association between SLC3A2/4F2 (in the SLC3A2/4F2-LAT2 heterodimer) and ICAM1. {ECO:0000269|PubMed	12716892}. 
# InterPro	IPR002293	AA/rel_permease1
# InterPro	IPR004760	L_AA_transporter
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04974	Protein digestion and absorption
# MIM	604235	gene
# MISCELLANEOUS	LAT2_HUMAN	L-leucine transport activity inhibited by small zwitterionic amino acids (i.e. glycine, alanine, serine, threonine asparginine, glutamine, methionine, leucine, isoleucine, valine, phenylalanine, tyrosine, tryptophan, histidine and cysteine) and by glutamine and asparginine. Methionine uptake was inhibited by the L-system substrates L-leucine, 2-amino-bicyclo-(2,2,1)- heptane-2-carboxylate (BCH), L-cysteine and by the MeHg-L-cysteine complex and structurally related S-ethyl-L-cysteine. MeHg-L- cysteine uptake is inhibited by L-methionine, L-leucine, BCH and S-ethyl-L-cysteine. L-leucine uptake was inhibited by L-CNSO. 
# Organism	LAT2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11785	PTHR11785
# PIRSF	PIRSF006060	AA_transporter
# Pfam	PF13520	AA_permease_2
# Proteomes	UP000005640	Chromosome 14
# Reactome	R-HSA-210991	Basigin interactions
# Reactome	R-HSA-352230	Amino acid transport across the plasma membrane
# RecName	LAT2_HUMAN	Large neutral amino acids transporter small subunit 2
# RefSeq	NP_001253965	NM_001267036.1. [Q9UHI5-4]
# RefSeq	NP_001253966	NM_001267037.1. [Q9UHI5-3]
# RefSeq	NP_036376	NM_012244.3. [Q9UHI5-1]
# RefSeq	NP_877392	NM_182728.2. [Q9UHI5-2]
# SEQUENCE CAUTION	Sequence=CAD62616.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	LAT2_HUMAN	Cytoplasm. Basolateral cell membrane; Multi- pass membrane protein. Note=Localized to the cytoplasm when expressed alone but when coexpressed with SLC3A2/4F2hc, is localized to the plasma membrane. Colocalized with SLC3A2/4F2hc at the basolateral membrane of kidney cortex proximal tubules and small intestine epithelia of the villi. 
# SUBUNIT	LAT2_HUMAN	Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc. {ECO 0000269|PubMed 10391915, ECO 0000269|PubMed 10574970, ECO 0000269|PubMed 11311135, ECO 0000269|PubMed 12716892, ECO 0000269|PubMed 15769744, ECO 0000269|PubMed 15918515}. 
# TCDB	2.A.3.8.20	the amino acid-polyamine-organocation (apc) family
# TIGRFAMs	TIGR00911	2A0308
# TISSUE SPECIFICITY	LAT2_HUMAN	Strongest expression is observed in kidney and moderate expression in placenta and brain, followed by liver, prostate, testis, ovary, lymph node, thymus, spleen, skeletal muscle and heart. Also expressed in fetal liver as well as in the retinal pigment epithelial cell line ARPE-19 and the intestinal epithelial cell line Caco-2. {ECO 0000269|PubMed 10391915, ECO 0000269|PubMed 15081149, ECO 0000269|PubMed 15918515, ECO 0000269|PubMed 16027961}. 
# UCSC	uc001wix	human. [Q9UHI5-1]
# eggNOG	COG0531	LUCA
# eggNOG	KOG1287	Eukaryota
BLAST	swissprot:LAT2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:LAT2_HUMAN
BioCyc	MetaCyc:ENSG00000092068-MONOMER	http://biocyc.org/getid?id=MetaCyc:ENSG00000092068-MONOMER
BioCyc	ZFISH:ENSG00000092068-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000092068-MONOMER
COXPRESdb	23428	http://coxpresdb.jp/data/gene/23428.shtml
CleanEx	HS_LAT2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_LAT2
CleanEx	HS_SLC7A8	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC7A8
DOI	10.1007/BF02977671	http://dx.doi.org/10.1007/BF02977671
DOI	10.1007/s00726-005-0221-x	http://dx.doi.org/10.1007/s00726-005-0221-x
DOI	10.1016/j.ijpharm.2004.01.035	http://dx.doi.org/10.1016/j.ijpharm.2004.01.035
DOI	10.1038/6815	http://dx.doi.org/10.1038/6815
DOI	10.1038/nature01348	http://dx.doi.org/10.1038/nature01348
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/BJ20020841	http://dx.doi.org/10.1042/BJ20020841
DOI	10.1074/jbc.274.28.19738	http://dx.doi.org/10.1074/jbc.274.28.19738
DOI	10.1074/jbc.274.49.34948	http://dx.doi.org/10.1074/jbc.274.49.34948
DOI	10.1074/jbc.M302777200	http://dx.doi.org/10.1074/jbc.M302777200
DOI	10.1074/jbc.M413164200	http://dx.doi.org/10.1074/jbc.M413164200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00120	http://www.drugbank.ca/drugs/DB00120
DrugBank	DB00130	http://www.drugbank.ca/drugs/DB00130
DrugBank	DB00160	http://www.drugbank.ca/drugs/DB00160
DrugBank	DB01235	http://www.drugbank.ca/drugs/DB01235
EMBL	AB037669	http://www.ebi.ac.uk/ena/data/view/AB037669
EMBL	AF135828	http://www.ebi.ac.uk/ena/data/view/AF135828
EMBL	AF135829	http://www.ebi.ac.uk/ena/data/view/AF135829
EMBL	AF135830	http://www.ebi.ac.uk/ena/data/view/AF135830
EMBL	AF171669	http://www.ebi.ac.uk/ena/data/view/AF171669
EMBL	AK296702	http://www.ebi.ac.uk/ena/data/view/AK296702
EMBL	AK300384	http://www.ebi.ac.uk/ena/data/view/AK300384
EMBL	AK313465	http://www.ebi.ac.uk/ena/data/view/AK313465
EMBL	AL117258	http://www.ebi.ac.uk/ena/data/view/AL117258
EMBL	BC052250	http://www.ebi.ac.uk/ena/data/view/BC052250
EMBL	BX248288	http://www.ebi.ac.uk/ena/data/view/BX248288
EMBL	CH471078	http://www.ebi.ac.uk/ena/data/view/CH471078
EMBL	CH471078	http://www.ebi.ac.uk/ena/data/view/CH471078
EMBL	Y18483	http://www.ebi.ac.uk/ena/data/view/Y18483
Ensembl	ENST00000316902	http://www.ensembl.org/id/ENST00000316902
Ensembl	ENST00000422941	http://www.ensembl.org/id/ENST00000422941
Ensembl	ENST00000453702	http://www.ensembl.org/id/ENST00000453702
Ensembl	ENST00000529705	http://www.ensembl.org/id/ENST00000529705
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0015101	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015101
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_function	GO:0015175	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015175
GO_function	GO:0015179	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015179
GO_function	GO:0015297	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297
GO_function	GO:0019534	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019534
GO_function	GO:0042605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042605
GO_process	GO:0006520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GO_process	GO:0009636	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009636
GO_process	GO:0015804	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015804
GO_process	GO:0050900	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050900
GO_process	GO:0055065	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055065
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GeneCards	SLC7A8	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC7A8
GeneID	23428	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23428
GeneTree	ENSGT00760000119037	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119037
HGNC	HGNC:11066	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11066
HOGENOM	HOG000098892	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000098892&db=HOGENOM6
HOVERGEN	HBG000476	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000476&db=HOVERGEN
HPA	CAB046015	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB046015
HPA	HPA051950	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA051950
HPA	HPA060672	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA060672
InParanoid	Q9UHI5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UHI5
InterPro	IPR002293	http://www.ebi.ac.uk/interpro/entry/IPR002293
InterPro	IPR004760	http://www.ebi.ac.uk/interpro/entry/IPR004760
Jabion	23428	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=23428
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:23428	http://www.genome.jp/dbget-bin/www_bget?hsa:23428
KEGG_Orthology	KO:K13781	http://www.genome.jp/dbget-bin/www_bget?KO:K13781
KEGG_Pathway	ko04974	http://www.genome.jp/kegg-bin/show_pathway?ko04974
MIM	604235	http://www.ncbi.nlm.nih.gov/omim/604235
OMA	PALYIVM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PALYIVM
OrthoDB	EOG091G07EM	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07EM
PANTHER	PTHR11785	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785
PSORT	swissprot:LAT2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:LAT2_HUMAN
PSORT-B	swissprot:LAT2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:LAT2_HUMAN
PSORT2	swissprot:LAT2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:LAT2_HUMAN
Pfam	PF13520	http://pfam.xfam.org/family/PF13520
PharmGKB	PA35926	http://www.pharmgkb.org/do/serve?objId=PA35926&objCls=Gene
Phobius	swissprot:LAT2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:LAT2_HUMAN
PhylomeDB	Q9UHI5	http://phylomedb.org/?seqid=Q9UHI5
ProteinModelPortal	Q9UHI5	http://www.proteinmodelportal.org/query/uniprot/Q9UHI5
PubMed	10080183	http://www.ncbi.nlm.nih.gov/pubmed/10080183
PubMed	10391915	http://www.ncbi.nlm.nih.gov/pubmed/10391915
PubMed	10574970	http://www.ncbi.nlm.nih.gov/pubmed/10574970
PubMed	11311135	http://www.ncbi.nlm.nih.gov/pubmed/11311135
PubMed	12117417	http://www.ncbi.nlm.nih.gov/pubmed/12117417
PubMed	12508121	http://www.ncbi.nlm.nih.gov/pubmed/12508121
PubMed	12716892	http://www.ncbi.nlm.nih.gov/pubmed/12716892
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15081149	http://www.ncbi.nlm.nih.gov/pubmed/15081149
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15769744	http://www.ncbi.nlm.nih.gov/pubmed/15769744
PubMed	15918515	http://www.ncbi.nlm.nih.gov/pubmed/15918515
PubMed	16027961	http://www.ncbi.nlm.nih.gov/pubmed/16027961
Reactome	R-HSA-210991	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-210991
Reactome	R-HSA-352230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-352230
RefSeq	NP_001253965	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001253965
RefSeq	NP_001253966	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001253966
RefSeq	NP_036376	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_036376
RefSeq	NP_877392	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_877392
STRING	9606.ENSP00000320378	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000320378&targetmode=cogs
TCDB	2.A.3.8.20	http://www.tcdb.org/search/result.php?tc=2.A.3.8.20
TIGRFAMs	TIGR00911	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00911
UCSC	uc001wix	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001wix&org=rat
UniGene	Hs.596643	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.596643
UniProtKB	LAT2_HUMAN	http://www.uniprot.org/uniprot/LAT2_HUMAN
UniProtKB-AC	Q9UHI5	http://www.uniprot.org/uniprot/Q9UHI5
charge	swissprot:LAT2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:LAT2_HUMAN
eggNOG	COG0531	http://eggnogapi.embl.de/nog_data/html/tree/COG0531
eggNOG	KOG1287	http://eggnogapi.embl.de/nog_data/html/tree/KOG1287
epestfind	swissprot:LAT2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:LAT2_HUMAN
garnier	swissprot:LAT2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:LAT2_HUMAN
helixturnhelix	swissprot:LAT2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:LAT2_HUMAN
hmoment	swissprot:LAT2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:LAT2_HUMAN
iep	swissprot:LAT2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:LAT2_HUMAN
inforesidue	swissprot:LAT2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:LAT2_HUMAN
neXtProt	NX_Q9UHI5	http://www.nextprot.org/db/entry/NX_Q9UHI5
octanol	swissprot:LAT2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:LAT2_HUMAN
pepcoil	swissprot:LAT2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:LAT2_HUMAN
pepdigest	swissprot:LAT2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:LAT2_HUMAN
pepinfo	swissprot:LAT2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:LAT2_HUMAN
pepnet	swissprot:LAT2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:LAT2_HUMAN
pepstats	swissprot:LAT2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:LAT2_HUMAN
pepwheel	swissprot:LAT2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:LAT2_HUMAN
pepwindow	swissprot:LAT2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:LAT2_HUMAN
sigcleave	swissprot:LAT2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:LAT2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GRIA3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=Flop; IsoId=P42263-1; Sequence=Displayed; Name=Flip; IsoId=P42263-2; Sequence=VSP_053351; 
# AltName	GRIA3_HUMAN	AMPA-selective glutamate receptor 3
# AltName	GRIA3_HUMAN	GluR-C
# AltName	GRIA3_HUMAN	GluR-K3
# AltName	GRIA3_HUMAN	Glutamate receptor ionotropic, AMPA 3
# BioGrid	109149	20
# CAUTION	It is uncertain whether Met-1 or Met-7 is the initiator. {ECO	0000305}.
# CCDS	CCDS14604	-. [P42263-1]
# CCDS	CCDS14605	-. [P42263-2]
# ChiTaRS	GRIA3	human
# DISEASE	GRIA3_HUMAN	Mental retardation, X-linked 94 (MRX94) [MIM 300699]  A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non- syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. MRX94 patients have moderate mental retardation. Other variable features are macrocephaly, seizures, myoclonic jerks, autistic behavior, asthenic body habitus, distal muscle weakness and hyporeflexia. {ECO 0000269|PubMed 17989220}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	GRIA3_HUMAN	The M4 transmembrane segment mediates tetramerization and is required for cell surface expression. {ECO 0000250}. 
# DrugBank	DB00898	Ethanol
# DrugBank	DB01356	Lithium
# Ensembl	ENST00000541091	ENSP00000446440; ENSG00000125675. [P42263-1]
# Ensembl	ENST00000620443	ENSP00000478489; ENSG00000125675. [P42263-2]
# Ensembl	ENST00000622768	ENSP00000481554; ENSG00000125675. [P42263-1]
# ExpressionAtlas	P42263	baseline and differential
# FUNCTION	GRIA3_HUMAN	Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. {ECO 0000269|PubMed 21172611}. 
# GO_component	GO:0005654	nucleoplasm; IDA:HPA.
# GO_component	GO:0005886	plasma membrane; IDA:HPA.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030666	endocytic vesicle membrane; TAS:Reactome.
# GO_component	GO:0032281	AMPA glutamate receptor complex; ISS:UniProtKB.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0004971	AMPA glutamate receptor activity; IDA:UniProtKB.
# GO_function	GO:0005231	excitatory extracellular ligand-gated ion channel activity; TAS:Reactome.
# GO_function	GO:0005234	extracellular-glutamate-gated ion channel activity; IEA:InterPro.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007215	glutamate receptor signaling pathway; TAS:ProtInc.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# Genevisible	P42263	HS
# HGNC	HGNC:4573	GRIA3
# InterPro	IPR001320	Iontro_rcpt
# InterPro	IPR001508	Iono_rcpt_met
# InterPro	IPR001828	ANF_lig-bd_rcpt
# InterPro	IPR019594	Glu/Gly-bd
# InterPro	IPR028082	Peripla_BP_I
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00577	[Congenital disorder; Mental retardation; Epilepsy] Rolandic epilepsy
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04713	Circadian entrainment
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04724	Glutamatergic synapse
# KEGG_Pathway	ko04728	Dopaminergic synapse
# KEGG_Pathway	ko04730	Long-term depression
# KEGG_Pathway	ko05031	Amphetamine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# KEGG_Pathway	ko05202	Transcriptional misregulation in cancer
# MIM	300699	phenotype
# MIM	305915	gene
# MISCELLANEOUS	GRIA3_HUMAN	The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate. 
# Organism	GRIA3_HUMAN	Homo sapiens (Human)
# Orphanet	364028	X-linked intellectual disability due to GRIA3 anomalies
# PIR	S49460	S49460
# PIR	S50128	S50128
# PIR	S53696	S53696
# PRINTS	PR00177	NMDARECEPTOR
# PTM	GRIA3_HUMAN	Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-621 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-847 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity). {ECO 0000250}. 
# Pfam	PF00060	Lig_chan
# Pfam	PF01094	ANF_receptor
# Pfam	PF10613	Lig_chan-Glu_bd
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-399710	Activation of AMPA receptors
# Reactome	R-HSA-399719	Trafficking of AMPA receptors
# Reactome	R-HSA-416993	Trafficking of GluR2-containing AMPA receptors
# Reactome	R-HSA-438066	Unblocking of NMDA receptor, glutamate binding and activation
# Reactome	R-HSA-8849932	SALM protein interactions at the synapses
# RecName	GRIA3_HUMAN	Glutamate receptor 3
# RefSeq	NP_000819	NM_000828.4
# RefSeq	NP_015564	NM_007325.4
# SIMILARITY	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA3 subfamily. {ECO	0000305}. 
# SMART	SM00079	PBPe
# SMART	SM00918	Lig_chan-Glu_bd
# SUBCELLULAR LOCATION	GRIA3_HUMAN	Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Interaction with CNIH2 and CNIH3 promotes cell surface expression. {ECO 0000250}. 
# SUBUNIT	Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with PRKCABP, GRIP1 and GRIP2 (By similarity). Found in a complex with GRIA1, GRIA2, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CACNG5 (By similarity). {ECO	0000250}. 
# SUPFAM	SSF53822	SSF53822
# TCDB	1.A.10.1	the glutamate-gated ion channel (gic) family of neurotransmitter receptors
# UCSC	uc033etl	human. [P42263-1]
# eggNOG	ENOG410XPSH	LUCA
# eggNOG	KOG1054	Eukaryota
BLAST	swissprot:GRIA3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GRIA3_HUMAN
BioCyc	ZFISH:ENSG00000125675-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000125675-MONOMER
COXPRESdb	2892	http://coxpresdb.jp/data/gene/2892.shtml
CleanEx	HS_GRIA3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GRIA3
DIP	DIP-46195N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-46195N
DOI	10.1002/(SICI)1096-8628(20000103)90:1<69::AID-AJMG12>3.3.CO	http://dx.doi.org/10.1002/(SICI)1096-8628(20000103)90:1<69::AID-AJMG12>3.3.CO
DOI	10.1006/geno.1999.6032	http://dx.doi.org/10.1006/geno.1999.6032
DOI	10.1016/0167-4781(94)90090-6	http://dx.doi.org/10.1016/0167-4781(94)90090-6
DOI	10.1016/j.neuron.2010.11.026	http://dx.doi.org/10.1016/j.neuron.2010.11.026
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1073/pnas.0708699104	http://dx.doi.org/10.1073/pnas.0708699104
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01356	http://www.drugbank.ca/drugs/DB01356
EMBL	AF159262	http://www.ebi.ac.uk/ena/data/view/AF159262
EMBL	AF159263	http://www.ebi.ac.uk/ena/data/view/AF159263
EMBL	AF159264	http://www.ebi.ac.uk/ena/data/view/AF159264
EMBL	AF159265	http://www.ebi.ac.uk/ena/data/view/AF159265
EMBL	AF159266	http://www.ebi.ac.uk/ena/data/view/AF159266
EMBL	AF159267	http://www.ebi.ac.uk/ena/data/view/AF159267
EMBL	AF159268	http://www.ebi.ac.uk/ena/data/view/AF159268
EMBL	AF159269	http://www.ebi.ac.uk/ena/data/view/AF159269
EMBL	AF159270	http://www.ebi.ac.uk/ena/data/view/AF159270
EMBL	AF159271	http://www.ebi.ac.uk/ena/data/view/AF159271
EMBL	AF159272	http://www.ebi.ac.uk/ena/data/view/AF159272
EMBL	AF159273	http://www.ebi.ac.uk/ena/data/view/AF159273
EMBL	AF159274	http://www.ebi.ac.uk/ena/data/view/AF159274
EMBL	AF159275	http://www.ebi.ac.uk/ena/data/view/AF159275
EMBL	AF159277	http://www.ebi.ac.uk/ena/data/view/AF159277
EMBL	AF166362	http://www.ebi.ac.uk/ena/data/view/AF166362
EMBL	AF166363	http://www.ebi.ac.uk/ena/data/view/AF166363
EMBL	AF166364	http://www.ebi.ac.uk/ena/data/view/AF166364
EMBL	AF166365	http://www.ebi.ac.uk/ena/data/view/AF166365
EMBL	AF166366	http://www.ebi.ac.uk/ena/data/view/AF166366
EMBL	AF166366	http://www.ebi.ac.uk/ena/data/view/AF166366
EMBL	AF166367	http://www.ebi.ac.uk/ena/data/view/AF166367
EMBL	AF166367	http://www.ebi.ac.uk/ena/data/view/AF166367
EMBL	AF166368	http://www.ebi.ac.uk/ena/data/view/AF166368
EMBL	AF166368	http://www.ebi.ac.uk/ena/data/view/AF166368
EMBL	AF166369	http://www.ebi.ac.uk/ena/data/view/AF166369
EMBL	AF166369	http://www.ebi.ac.uk/ena/data/view/AF166369
EMBL	AF166370	http://www.ebi.ac.uk/ena/data/view/AF166370
EMBL	AF166370	http://www.ebi.ac.uk/ena/data/view/AF166370
EMBL	AF166371	http://www.ebi.ac.uk/ena/data/view/AF166371
EMBL	AF166371	http://www.ebi.ac.uk/ena/data/view/AF166371
EMBL	AF166372	http://www.ebi.ac.uk/ena/data/view/AF166372
EMBL	AF166372	http://www.ebi.ac.uk/ena/data/view/AF166372
EMBL	AF166373	http://www.ebi.ac.uk/ena/data/view/AF166373
EMBL	AF166373	http://www.ebi.ac.uk/ena/data/view/AF166373
EMBL	AF166374	http://www.ebi.ac.uk/ena/data/view/AF166374
EMBL	AF166375	http://www.ebi.ac.uk/ena/data/view/AF166375
EMBL	AF167332	http://www.ebi.ac.uk/ena/data/view/AF167332
EMBL	AF167332	http://www.ebi.ac.uk/ena/data/view/AF167332
EMBL	AL035426	http://www.ebi.ac.uk/ena/data/view/AL035426
EMBL	AL035426	http://www.ebi.ac.uk/ena/data/view/AL035426
EMBL	AL035426	http://www.ebi.ac.uk/ena/data/view/AL035426
EMBL	AL035426	http://www.ebi.ac.uk/ena/data/view/AL035426
EMBL	AL035426	http://www.ebi.ac.uk/ena/data/view/AL035426
EMBL	AL035426	http://www.ebi.ac.uk/ena/data/view/AL035426
EMBL	AL035426	http://www.ebi.ac.uk/ena/data/view/AL035426
EMBL	AL035426	http://www.ebi.ac.uk/ena/data/view/AL035426
EMBL	AL035426	http://www.ebi.ac.uk/ena/data/view/AL035426
EMBL	AL035426	http://www.ebi.ac.uk/ena/data/view/AL035426
EMBL	AL356213	http://www.ebi.ac.uk/ena/data/view/AL356213
EMBL	AL356213	http://www.ebi.ac.uk/ena/data/view/AL356213
EMBL	AL356213	http://www.ebi.ac.uk/ena/data/view/AL356213
EMBL	AL356213	http://www.ebi.ac.uk/ena/data/view/AL356213
EMBL	AL356213	http://www.ebi.ac.uk/ena/data/view/AL356213
EMBL	AL356213	http://www.ebi.ac.uk/ena/data/view/AL356213
EMBL	AL356213	http://www.ebi.ac.uk/ena/data/view/AL356213
EMBL	AL356213	http://www.ebi.ac.uk/ena/data/view/AL356213
EMBL	AL356213	http://www.ebi.ac.uk/ena/data/view/AL356213
EMBL	AL356213	http://www.ebi.ac.uk/ena/data/view/AL356213
EMBL	AL590139	http://www.ebi.ac.uk/ena/data/view/AL590139
EMBL	AL590139	http://www.ebi.ac.uk/ena/data/view/AL590139
EMBL	AL590139	http://www.ebi.ac.uk/ena/data/view/AL590139
EMBL	AL590139	http://www.ebi.ac.uk/ena/data/view/AL590139
EMBL	AL590139	http://www.ebi.ac.uk/ena/data/view/AL590139
EMBL	AL590139	http://www.ebi.ac.uk/ena/data/view/AL590139
EMBL	AL590139	http://www.ebi.ac.uk/ena/data/view/AL590139
EMBL	AL590139	http://www.ebi.ac.uk/ena/data/view/AL590139
EMBL	AL590139	http://www.ebi.ac.uk/ena/data/view/AL590139
EMBL	AL590139	http://www.ebi.ac.uk/ena/data/view/AL590139
EMBL	CH471107	http://www.ebi.ac.uk/ena/data/view/CH471107
EMBL	CH471107	http://www.ebi.ac.uk/ena/data/view/CH471107
EMBL	U10301	http://www.ebi.ac.uk/ena/data/view/U10301
EMBL	U10302	http://www.ebi.ac.uk/ena/data/view/U10302
EMBL	X82068	http://www.ebi.ac.uk/ena/data/view/X82068
EMBL	Z82899	http://www.ebi.ac.uk/ena/data/view/Z82899
EMBL	Z82899	http://www.ebi.ac.uk/ena/data/view/Z82899
EMBL	Z82899	http://www.ebi.ac.uk/ena/data/view/Z82899
EMBL	Z82899	http://www.ebi.ac.uk/ena/data/view/Z82899
EMBL	Z82899	http://www.ebi.ac.uk/ena/data/view/Z82899
EMBL	Z82899	http://www.ebi.ac.uk/ena/data/view/Z82899
EMBL	Z82899	http://www.ebi.ac.uk/ena/data/view/Z82899
EMBL	Z82899	http://www.ebi.ac.uk/ena/data/view/Z82899
EMBL	Z82899	http://www.ebi.ac.uk/ena/data/view/Z82899
EMBL	Z82899	http://www.ebi.ac.uk/ena/data/view/Z82899
EMBL	Z83848	http://www.ebi.ac.uk/ena/data/view/Z83848
EMBL	Z83848	http://www.ebi.ac.uk/ena/data/view/Z83848
EMBL	Z83848	http://www.ebi.ac.uk/ena/data/view/Z83848
EMBL	Z83848	http://www.ebi.ac.uk/ena/data/view/Z83848
EMBL	Z83848	http://www.ebi.ac.uk/ena/data/view/Z83848
EMBL	Z83848	http://www.ebi.ac.uk/ena/data/view/Z83848
EMBL	Z83848	http://www.ebi.ac.uk/ena/data/view/Z83848
EMBL	Z83848	http://www.ebi.ac.uk/ena/data/view/Z83848
EMBL	Z83848	http://www.ebi.ac.uk/ena/data/view/Z83848
EMBL	Z83848	http://www.ebi.ac.uk/ena/data/view/Z83848
Ensembl	ENST00000541091	http://www.ensembl.org/id/ENST00000541091
Ensembl	ENST00000620443	http://www.ensembl.org/id/ENST00000620443
Ensembl	ENST00000622768	http://www.ensembl.org/id/ENST00000622768
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030666
GO_component	GO:0032281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032281
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0004971	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004971
GO_function	GO:0005231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005231
GO_function	GO:0005234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005234
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007215
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GeneCards	GRIA3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GRIA3
GeneID	2892	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2892
GeneTree	ENSGT00760000118920	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118920
HGNC	HGNC:4573	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4573
HOVERGEN	HBG051839	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051839&db=HOVERGEN
HPA	HPA058659	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA058659
InParanoid	P42263	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P42263
InterPro	IPR001320	http://www.ebi.ac.uk/interpro/entry/IPR001320
InterPro	IPR001508	http://www.ebi.ac.uk/interpro/entry/IPR001508
InterPro	IPR001828	http://www.ebi.ac.uk/interpro/entry/IPR001828
InterPro	IPR019594	http://www.ebi.ac.uk/interpro/entry/IPR019594
InterPro	IPR028082	http://www.ebi.ac.uk/interpro/entry/IPR028082
Jabion	2892	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2892
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00577	http://www.genome.jp/dbget-bin/www_bget?H00577
KEGG_Gene	hsa:2892	http://www.genome.jp/dbget-bin/www_bget?hsa:2892
KEGG_Orthology	KO:K05199	http://www.genome.jp/dbget-bin/www_bget?KO:K05199
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04713	http://www.genome.jp/kegg-bin/show_pathway?ko04713
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
KEGG_Pathway	ko04728	http://www.genome.jp/kegg-bin/show_pathway?ko04728
KEGG_Pathway	ko04730	http://www.genome.jp/kegg-bin/show_pathway?ko04730
KEGG_Pathway	ko05031	http://www.genome.jp/kegg-bin/show_pathway?ko05031
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
KEGG_Pathway	ko05202	http://www.genome.jp/kegg-bin/show_pathway?ko05202
MIM	300699	http://www.ncbi.nlm.nih.gov/omim/300699
MIM	305915	http://www.ncbi.nlm.nih.gov/omim/305915
OMA	DQLPSND	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DQLPSND
Orphanet	364028	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=364028
OrthoDB	EOG091G11CB	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G11CB
PRINTS	PR00177	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00177
PSORT	swissprot:GRIA3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GRIA3_HUMAN
PSORT-B	swissprot:GRIA3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GRIA3_HUMAN
PSORT2	swissprot:GRIA3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GRIA3_HUMAN
Pfam	PF00060	http://pfam.xfam.org/family/PF00060
Pfam	PF01094	http://pfam.xfam.org/family/PF01094
Pfam	PF10613	http://pfam.xfam.org/family/PF10613
PharmGKB	PA28968	http://www.pharmgkb.org/do/serve?objId=PA28968&objCls=Gene
Phobius	swissprot:GRIA3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GRIA3_HUMAN
PhylomeDB	P42263	http://phylomedb.org/?seqid=P42263
ProteinModelPortal	P42263	http://www.proteinmodelportal.org/query/uniprot/P42263
PubMed	10602120	http://www.ncbi.nlm.nih.gov/pubmed/10602120
PubMed	10644433	http://www.ncbi.nlm.nih.gov/pubmed/10644433
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	17989220	http://www.ncbi.nlm.nih.gov/pubmed/17989220
PubMed	21172611	http://www.ncbi.nlm.nih.gov/pubmed/21172611
PubMed	7918660	http://www.ncbi.nlm.nih.gov/pubmed/7918660
Reactome	R-HSA-399710	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-399710
Reactome	R-HSA-399719	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-399719
Reactome	R-HSA-416993	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-416993
Reactome	R-HSA-438066	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-438066
Reactome	R-HSA-8849932	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8849932
RefSeq	NP_000819	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000819
RefSeq	NP_015564	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_015564
SMART	SM00079	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00079
SMART	SM00918	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00918
SMR	P42263	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P42263
STRING	9606.ENSP00000264357	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000264357&targetmode=cogs
SUPFAM	SSF53822	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822
TCDB	1.A.10.1	http://www.tcdb.org/search/result.php?tc=1.A.10.1
UCSC	uc033etl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc033etl&org=rat
UniGene	Hs.377070	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.377070
UniProtKB	GRIA3_HUMAN	http://www.uniprot.org/uniprot/GRIA3_HUMAN
UniProtKB-AC	P42263	http://www.uniprot.org/uniprot/P42263
charge	swissprot:GRIA3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GRIA3_HUMAN
eggNOG	ENOG410XPSH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPSH
eggNOG	KOG1054	http://eggnogapi.embl.de/nog_data/html/tree/KOG1054
epestfind	swissprot:GRIA3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GRIA3_HUMAN
garnier	swissprot:GRIA3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GRIA3_HUMAN
helixturnhelix	swissprot:GRIA3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GRIA3_HUMAN
hmoment	swissprot:GRIA3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GRIA3_HUMAN
iep	swissprot:GRIA3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GRIA3_HUMAN
inforesidue	swissprot:GRIA3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GRIA3_HUMAN
neXtProt	NX_P42263	http://www.nextprot.org/db/entry/NX_P42263
octanol	swissprot:GRIA3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GRIA3_HUMAN
pepcoil	swissprot:GRIA3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GRIA3_HUMAN
pepdigest	swissprot:GRIA3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GRIA3_HUMAN
pepinfo	swissprot:GRIA3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GRIA3_HUMAN
pepnet	swissprot:GRIA3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GRIA3_HUMAN
pepstats	swissprot:GRIA3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GRIA3_HUMAN
pepwheel	swissprot:GRIA3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GRIA3_HUMAN
pepwindow	swissprot:GRIA3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GRIA3_HUMAN
sigcleave	swissprot:GRIA3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GRIA3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	MRP6_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O95255-1; Sequence=Displayed; Name=2; Synonyms=URG7; IsoId=O95255-2; Sequence=VSP_047315, VSP_047316; Name=3; Synonyms=Delta19Delta24; IsoId=O95255-3; Sequence=VSP_057077, VSP_057078; Note=May function as a a half transporter.; 
# AltName	MRP6_HUMAN	ATP-binding cassette sub-family C member 6
# AltName	MRP6_HUMAN	Anthracycline resistance-associated protein
# AltName	MRP6_HUMAN	Multi-specific organic anion transporter E
# BioGrid	106863	5
# CCDS	CCDS10568	-. [O95255-1]
# CCDS	CCDS58430	-. [O95255-2]
# ChiTaRS	ABCC6	human
# DISEASE	MRP6_HUMAN	Arterial calcification of infancy, generalized, 2 (GACI2) [MIM 614473]  A severe autosomal recessive disorder characterized by calcification of the internal elastic lamina of muscular arteries and stenosis due to myointimal proliferation. The disorder is often fatal within the first 6 months of life because of myocardial ischemia resulting in refractory heart failure. {ECO 0000269|PubMed 22209248}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	MRP6_HUMAN	Pseudoxanthoma elasticum (PXE) [MIM 264800]  A multisystem disorder characterized by accumulation of mineralized and fragmented elastic fibers in the skin, vascular walls, and Burch membrane in the eye. Clinically, patients exhibit characteristic lesions of the posterior segment of the eye including peau d'orange, angioid streaks, and choroidal neovascularizations, of the skin including soft, ivory colored papules in a reticular pattern that predominantly affect the neck and large flexor surfaces, and of the cardiovascular system with peripheral and coronary arterial occlusive disease as well as gastrointestinal bleedings. {ECO 0000269|PubMed 10811882, ECO 0000269|PubMed 10835642, ECO 0000269|PubMed 10954200, ECO 0000269|PubMed 11427982, ECO 0000269|PubMed 11536079, ECO 0000269|PubMed 11702217, ECO 0000269|PubMed 15086542, ECO 0000269|PubMed 15098239, ECO 0000269|PubMed 15459974, ECO 0000269|PubMed 16086317, ECO 0000269|PubMed 17617515, ECO 0000269|PubMed 19339160, ECO 0000269|PubMed 20034067, ECO 0000269|PubMed 25615550}. Note=The disease is caused by mutations affecting the gene represented in this entry. Homozygous or compound heterozygous ABCC6 mutations have been found in the overwhelming majority of cases. Individuals carrying heterozygous mutations express limited manifestations of the pseudoxanthoma elasticum phenotype. 
# DrugBank	DB00328	Indomethacin
# DrugBank	DB00444	Teniposide
# DrugBank	DB00515	Cisplatin
# DrugBank	DB00570	Vinblastine
# DrugBank	DB00694	Daunorubicin
# DrugBank	DB00773	Etoposide
# DrugBank	DB00970	Dactinomycin
# DrugBank	DB00997	Doxorubicin
# DrugBank	DB01032	Probenecid
# DrugBank	DB01138	Sulfinpyrazone
# Ensembl	ENST00000205557	ENSP00000205557; ENSG00000091262. [O95255-1]
# Ensembl	ENST00000456970	ENSP00000405002; ENSG00000091262. [O95255-3]
# Ensembl	ENST00000575728	ENSP00000461686; ENSG00000091262. [O95255-2]
# Ensembl	ENST00000600761	ENSP00000481979; ENSG00000275331. [O95255-2]
# Ensembl	ENST00000622290	ENSP00000483331; ENSG00000091262. [O95255-3]
# ExpressionAtlas	O95255	baseline and differential
# FUNCTION	MRP6_HUMAN	Isoform 1  May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS). {ECO 0000269|PubMed 11880368}. 
# FUNCTION	MRP6_HUMAN	Isoform 2  Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases. {ECO 0000269|PubMed 23912081}. 
# GO_component	GO:0005634	nucleus; IDA:HPA.
# GO_component	GO:0005789	endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; IDA:HPA.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016324	apical plasma membrane; IEA:Ensembl.
# GO_component	GO:0016328	lateral plasma membrane; IEA:Ensembl.
# GO_function	GO:0005215	transporter activity; TAS:ProtInc.
# GO_function	GO:0005524	ATP binding; TAS:ProtInc.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; TAS:ProtInc.
# GO_function	GO:0043225	ATPase-coupled anion transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007601	visual perception; IEA:UniProtKB-KW.
# GO_process	GO:0042493	response to drug; TAS:ProtInc.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 2.
# Genevisible	O95255	HS
# HGNC	HGNC:57	ABCC6
# INDUCTION	Isoform 2 is induced by HBV x antigen upon hepatitis B viral infection. {ECO:0000269|PubMed	23912081}. 
# IntAct	O95255	5
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR005292	Multidrug-R_assoc
# InterPro	IPR011527	ABC1_TM_dom
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR027417	P-loop_NTPase
# InterPro	IPR030239	ABCC6
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Disease	H00560	[Developmental disorder; Skin and connective tissue disease] Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency
# KEGG_Disease	H01002	[Cardiovascular Disease] Generalized arterial calcification of infancy
# KEGG_Pathway	ko02010	ABC transporters
# MIM	264800	phenotype
# MIM	603234	gene
# MIM	614473	phenotype
# Organism	MRP6_HUMAN	Homo sapiens (Human)
# Orphanet	51608	Generalized arterial calcification of infancy
# Orphanet	758	Pseudoxanthoma elasticum
# PANTHER	PTHR24223:SF226	PTHR24223:SF226; 2
# PROSITE	PS00211	ABC_TRANSPORTER_1; 2
# PROSITE	PS50893	ABC_TRANSPORTER_2; 2
# PROSITE	PS50929	ABC_TM1F; 2
# Pfam	PF00005	ABC_tran; 2
# Pfam	PF00664	ABC_membrane; 2
# Proteomes	UP000005640	Chromosome 16
# Reactome	R-HSA-382556	ABC-family proteins mediated transport
# RecName	MRP6_HUMAN	Multidrug resistance-associated protein 6
# RefSeq	NP_001072996	NM_001079528.3. [O95255-2]
# RefSeq	NP_001162	NM_001171.5
# SEQUENCE CAUTION	Sequence=AAC15785.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 2 ABC transmembrane type-1 domains. {ECO:0000255|PROSITE-ProRule	PRU00441}. 
# SIMILARITY	Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA; 2
# SUBCELLULAR LOCATION	MRP6_HUMAN	Isoform 1  Basolateral cell membrane {ECO 0000269|PubMed 12901863, ECO 0000269|PubMed 23625951}; Multi- pass membrane protein {ECO 0000255}. 
# SUBCELLULAR LOCATION	MRP6_HUMAN	Isoform 2  Endoplasmic reticulum membrane {ECO 0000269|PubMed 23912081}; Single-pass membrane protein {ECO 0000255}. 
# SUPFAM	SSF52540	SSF52540; 2
# SUPFAM	SSF90123	SSF90123; 2
# TCDB	3.A.1.208.10	the atp-binding cassette (abc) superfamily
# TIGRFAMs	TIGR00957	MRP_assoc_pro
# TISSUE SPECIFICITY	MRP6_HUMAN	Expressed in kidney and liver. Very low expression in other tissues. 
# UCSC	uc002den	human. [O95255-1]
# WEB RESOURCE	MRP6_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=O95255";
# WEB RESOURCE	MRP6_HUMAN	Name=Mutations of the ABCC6 gene; Note=Retina International's Scientific Newsletter; URL="http //www.retina-international.org/files/sci-news/abcc6mut.htm"; 
# eggNOG	COG1132	LUCA
# eggNOG	KOG0054	Eukaryota
BLAST	swissprot:MRP6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MRP6_HUMAN
BioCyc	ZFISH:ENSG00000091262-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000091262-MONOMER
COXPRESdb	368	http://coxpresdb.jp/data/gene/368.shtml
CleanEx	HS_ABCC6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCC6
DOI	10.1002/1098-1004(200011)16:5<449::AID-HUMU24>3.0.CO	http://dx.doi.org/10.1002/1098-1004(200011)16:5<449::AID-HUMU24>3.0.CO
DOI	10.1002/ajmg.a.20632	http://dx.doi.org/10.1002/ajmg.a.20632
DOI	10.1002/ajmg.a.33162	http://dx.doi.org/10.1002/ajmg.a.33162
DOI	10.1002/humu.20206	http://dx.doi.org/10.1002/humu.20206
DOI	10.1002/humu.9284	http://dx.doi.org/10.1002/humu.9284
DOI	10.1006/bbrc.2000.3101	http://dx.doi.org/10.1006/bbrc.2000.3101
DOI	10.1006/geno.1999.5927	http://dx.doi.org/10.1006/geno.1999.5927
DOI	10.1007/s001090000114	http://dx.doi.org/10.1007/s001090000114
DOI	10.1007/s004390100582	http://dx.doi.org/10.1007/s004390100582
DOI	10.1007/s100380170003	http://dx.doi.org/10.1007/s100380170003
DOI	10.1016/S0006-291X(03)01349-4	http://dx.doi.org/10.1016/S0006-291X(03)01349-4
DOI	10.1016/S1471-4914(00)01869-4	http://dx.doi.org/10.1016/S1471-4914(00)01869-4
DOI	10.1016/j.ajhg.2011.11.020	http://dx.doi.org/10.1016/j.ajhg.2011.11.020
DOI	10.1016/j.febslet.2013.07.042	http://dx.doi.org/10.1016/j.febslet.2013.07.042
DOI	10.1016/j.jdermsci.2009.02.008	http://dx.doi.org/10.1016/j.jdermsci.2009.02.008
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/76102	http://dx.doi.org/10.1038/76102
DOI	10.1038/jid.2015.10	http://dx.doi.org/10.1038/jid.2015.10
DOI	10.1038/nature03187	http://dx.doi.org/10.1038/nature03187
DOI	10.1038/nature07485	http://dx.doi.org/10.1038/nature07485
DOI	10.1038/sj.bjc.6690527	http://dx.doi.org/10.1038/sj.bjc.6690527
DOI	10.1053/jhep.2001.25545	http://dx.doi.org/10.1053/jhep.2001.25545
DOI	10.1073/pnas.100041297	http://dx.doi.org/10.1073/pnas.100041297
DOI	10.1074/jbc.M110918200	http://dx.doi.org/10.1074/jbc.M110918200
DOI	10.1086/323704	http://dx.doi.org/10.1086/323704
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.0022-202X.2004.22312.x	http://dx.doi.org/10.1111/j.0022-202X.2004.22312.x
DOI	10.1136/jmg.2007.051094	http://dx.doi.org/10.1136/jmg.2007.051094
DOI	10.1155/2008/912478	http://dx.doi.org/10.1155/2008/912478
DOI	10.1161/CIRCRESAHA.111.300194	http://dx.doi.org/10.1161/CIRCRESAHA.111.300194
DrugBank	DB00328	http://www.drugbank.ca/drugs/DB00328
DrugBank	DB00444	http://www.drugbank.ca/drugs/DB00444
DrugBank	DB00515	http://www.drugbank.ca/drugs/DB00515
DrugBank	DB00570	http://www.drugbank.ca/drugs/DB00570
DrugBank	DB00694	http://www.drugbank.ca/drugs/DB00694
DrugBank	DB00773	http://www.drugbank.ca/drugs/DB00773
DrugBank	DB00970	http://www.drugbank.ca/drugs/DB00970
DrugBank	DB00997	http://www.drugbank.ca/drugs/DB00997
DrugBank	DB01032	http://www.drugbank.ca/drugs/DB01032
DrugBank	DB01138	http://www.drugbank.ca/drugs/DB01138
EMBL	AC136624	http://www.ebi.ac.uk/ena/data/view/AC136624
EMBL	AF076622	http://www.ebi.ac.uk/ena/data/view/AF076622
EMBL	AF168791	http://www.ebi.ac.uk/ena/data/view/AF168791
EMBL	AM711638	http://www.ebi.ac.uk/ena/data/view/AM711638
EMBL	AM774324	http://www.ebi.ac.uk/ena/data/view/AM774324
EMBL	AY078405	http://www.ebi.ac.uk/ena/data/view/AY078405
EMBL	BC050733	http://www.ebi.ac.uk/ena/data/view/BC050733
EMBL	BC131732	http://www.ebi.ac.uk/ena/data/view/BC131732
EMBL	U91318	http://www.ebi.ac.uk/ena/data/view/U91318
Ensembl	ENST00000205557	http://www.ensembl.org/id/ENST00000205557
Ensembl	ENST00000456970	http://www.ensembl.org/id/ENST00000456970
Ensembl	ENST00000575728	http://www.ensembl.org/id/ENST00000575728
Ensembl	ENST00000600761	http://www.ensembl.org/id/ENST00000600761
Ensembl	ENST00000622290	http://www.ensembl.org/id/ENST00000622290
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0016328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016328
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GO_function	GO:0043225	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043225
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007601	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007601
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCC6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCC6
GeneID	368	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=368
GeneTree	ENSGT00860000133687	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00860000133687
H-InvDB	HIX0026937	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0026937
H-InvDB	HIX0038600	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0038600
HGNC	HGNC:57	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:57
HOVERGEN	HBG108314	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108314&db=HOVERGEN
HPA	HPA038105	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA038105
InParanoid	O95255	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O95255
IntAct	O95255	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O95255*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR005292	http://www.ebi.ac.uk/interpro/entry/IPR005292
InterPro	IPR011527	http://www.ebi.ac.uk/interpro/entry/IPR011527
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
InterPro	IPR030239	http://www.ebi.ac.uk/interpro/entry/IPR030239
Jabion	368	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=368
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Disease	H00560	http://www.genome.jp/dbget-bin/www_bget?H00560
KEGG_Disease	H01002	http://www.genome.jp/dbget-bin/www_bget?H01002
KEGG_Gene	hsa:368	http://www.genome.jp/dbget-bin/www_bget?hsa:368
KEGG_Orthology	KO:K05669	http://www.genome.jp/dbget-bin/www_bget?KO:K05669
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
MIM	264800	http://www.ncbi.nlm.nih.gov/omim/264800
MIM	603234	http://www.ncbi.nlm.nih.gov/omim/603234
MIM	614473	http://www.ncbi.nlm.nih.gov/omim/614473
OMA	LWADDPT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LWADDPT
Orphanet	51608	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=51608
Orphanet	758	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=758
OrthoDB	EOG091G00IN	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00IN
PANTHER	PTHR24223:SF226	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24223:SF226
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PROSITE	PS50929	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929
PSORT	swissprot:MRP6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MRP6_HUMAN
PSORT-B	swissprot:MRP6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MRP6_HUMAN
PSORT2	swissprot:MRP6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MRP6_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF00664	http://pfam.xfam.org/family/PF00664
PharmGKB	PA58	http://www.pharmgkb.org/do/serve?objId=PA58&objCls=Gene
Phobius	swissprot:MRP6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MRP6_HUMAN
PhylomeDB	O95255	http://phylomedb.org/?seqid=O95255
ProteinModelPortal	O95255	http://www.proteinmodelportal.org/query/uniprot/O95255
PubMed	10424734	http://www.ncbi.nlm.nih.gov/pubmed/10424734
PubMed	10493829	http://www.ncbi.nlm.nih.gov/pubmed/10493829
PubMed	10811882	http://www.ncbi.nlm.nih.gov/pubmed/10811882
PubMed	10835642	http://www.ncbi.nlm.nih.gov/pubmed/10835642
PubMed	10913334	http://www.ncbi.nlm.nih.gov/pubmed/10913334
PubMed	10954200	http://www.ncbi.nlm.nih.gov/pubmed/10954200
PubMed	11058917	http://www.ncbi.nlm.nih.gov/pubmed/11058917
PubMed	11427982	http://www.ncbi.nlm.nih.gov/pubmed/11427982
PubMed	11431746	http://www.ncbi.nlm.nih.gov/pubmed/11431746
PubMed	11536079	http://www.ncbi.nlm.nih.gov/pubmed/11536079
PubMed	11702217	http://www.ncbi.nlm.nih.gov/pubmed/11702217
PubMed	11776382	http://www.ncbi.nlm.nih.gov/pubmed/11776382
PubMed	11880368	http://www.ncbi.nlm.nih.gov/pubmed/11880368
PubMed	12901863	http://www.ncbi.nlm.nih.gov/pubmed/12901863
PubMed	15086542	http://www.ncbi.nlm.nih.gov/pubmed/15086542
PubMed	15098239	http://www.ncbi.nlm.nih.gov/pubmed/15098239
PubMed	15459974	http://www.ncbi.nlm.nih.gov/pubmed/15459974
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15616553	http://www.ncbi.nlm.nih.gov/pubmed/15616553
PubMed	16086317	http://www.ncbi.nlm.nih.gov/pubmed/16086317
PubMed	17617515	http://www.ncbi.nlm.nih.gov/pubmed/17617515
PubMed	18987736	http://www.ncbi.nlm.nih.gov/pubmed/18987736
PubMed	19339160	http://www.ncbi.nlm.nih.gov/pubmed/19339160
PubMed	20034067	http://www.ncbi.nlm.nih.gov/pubmed/20034067
PubMed	21318057	http://www.ncbi.nlm.nih.gov/pubmed/21318057
PubMed	22209248	http://www.ncbi.nlm.nih.gov/pubmed/22209248
PubMed	23625951	http://www.ncbi.nlm.nih.gov/pubmed/23625951
PubMed	23912081	http://www.ncbi.nlm.nih.gov/pubmed/23912081
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25615550	http://www.ncbi.nlm.nih.gov/pubmed/25615550
PubMed	9892204	http://www.ncbi.nlm.nih.gov/pubmed/9892204
Reactome	R-HSA-382556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-382556
RefSeq	NP_001072996	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001072996
RefSeq	NP_001162	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001162
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
STRING	9606.ENSP00000205557	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000205557&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
SUPFAM	SSF90123	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123
TCDB	3.A.1.208.10	http://www.tcdb.org/search/result.php?tc=3.A.1.208.10
TIGRFAMs	TIGR00957	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00957
UCSC	uc002den	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002den&org=rat
UniGene	Hs.442182	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.442182
UniProtKB	MRP6_HUMAN	http://www.uniprot.org/uniprot/MRP6_HUMAN
UniProtKB-AC	O95255	http://www.uniprot.org/uniprot/O95255
charge	swissprot:MRP6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MRP6_HUMAN
eggNOG	COG1132	http://eggnogapi.embl.de/nog_data/html/tree/COG1132
eggNOG	KOG0054	http://eggnogapi.embl.de/nog_data/html/tree/KOG0054
epestfind	swissprot:MRP6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MRP6_HUMAN
garnier	swissprot:MRP6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MRP6_HUMAN
helixturnhelix	swissprot:MRP6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MRP6_HUMAN
hmoment	swissprot:MRP6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MRP6_HUMAN
iep	swissprot:MRP6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MRP6_HUMAN
inforesidue	swissprot:MRP6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MRP6_HUMAN
neXtProt	NX_O95255	http://www.nextprot.org/db/entry/NX_O95255
octanol	swissprot:MRP6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MRP6_HUMAN
pepcoil	swissprot:MRP6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MRP6_HUMAN
pepdigest	swissprot:MRP6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MRP6_HUMAN
pepinfo	swissprot:MRP6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MRP6_HUMAN
pepnet	swissprot:MRP6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MRP6_HUMAN
pepstats	swissprot:MRP6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MRP6_HUMAN
pepwheel	swissprot:MRP6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MRP6_HUMAN
pepwindow	swissprot:MRP6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MRP6_HUMAN
sigcleave	swissprot:MRP6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MRP6_HUMAN
## Database	ID	URL or Descriptions
# AltName	PERF_HUMAN	Cytolysin
# AltName	PERF_HUMAN	Lymphocyte pore-forming protein
# BioGrid	111542	5
# DISEASE	PERF_HUMAN	Familial hemophagocytic lymphohistiocytosis 2 (FHL2) [MIM 603553]  A rare disorder characterized by immune dysregulation with hypercytokinemia, defective function of natural killer cell, and massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits and ataxia. {ECO 0000269|PubMed 10583959, ECO 0000269|PubMed 11179007}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	PERF_HUMAN	The C2 domain mediates calcium-dependent binding to lipid membranes. A subsequent conformation change leads to membrane insertion of beta-hairpin structures and pore formation. The pore is formed by transmembrane beta-strands. 
# Ensembl	ENST00000373209	ENSP00000362305; ENSG00000180644
# Ensembl	ENST00000441259	ENSP00000398568; ENSG00000180644
# FUNCTION	PERF_HUMAN	Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. {ECO 0000269|PubMed 20038786, ECO 0000269|PubMed 20225066, ECO 0000269|PubMed 20889983, ECO 0000269|PubMed 21037563, ECO 0000269|PubMed 9058810, ECO 0000269|PubMed 9164947}. 
# GO_component	GO:0005576	extracellular region; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IDA:UniProtKB.
# GO_component	GO:0016023	cytoplasmic, membrane-bounded vesicle; IEA:Ensembl.
# GO_component	GO:0031904	endosome lumen; IEA:UniProtKB-SubCell.
# GO_component	GO:0044194	cytolytic granule; ISS:UniProtKB.
# GO_function	GO:0005509	calcium ion binding; ISS:UniProtKB.
# GO_function	GO:0022829	wide pore channel activity; IDA:UniProtKB.
# GO_process	GO:0001771	immunological synapse formation; IDA:UniProtKB.
# GO_process	GO:0002357	defense response to tumor cell; ISS:UniProtKB.
# GO_process	GO:0002418	immune response to tumor cell; ISS:UniProtKB.
# GO_process	GO:0006915	apoptotic process; TAS:ProtInc.
# GO_process	GO:0006968	cellular defense response; TAS:ProtInc.
# GO_process	GO:0019835	cytolysis; ISS:UniProtKB.
# GO_process	GO:0051260	protein homooligomerization; IDA:UniProtKB.
# GO_process	GO:0051607	defense response to virus; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005576	extracellular region
# GOslim_component	GO:0005764	lysosome
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0008219	cell death
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# Gene3D	2.60.40.150	-; 1.
# Genevisible	P14222	HS
# HGNC	HGNC:9360	PRF1
# INDUCTION	Repressed by contact with target cells. {ECO:0000269|PubMed	8676885}. 
# INTERACTION	PERF_HUMAN	P10144 GZMB; NbExp=3; IntAct=EBI-724466, EBI-2505785; Q15323 KRT31; NbExp=5; IntAct=EBI-724466, EBI-948001; 
# IntAct	P14222	6
# InterPro	IPR000008	C2_dom
# InterPro	IPR020863	MACPF_CS
# InterPro	IPR020864	MACPF
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04090	 Cellular antigens
# KEGG_Disease	H00109	[Primary immunodeficiency] STX11 deficiency
# KEGG_Pathway	ko04650	Natural killer cell mediated cytotoxicity
# KEGG_Pathway	ko04940	Type I diabetes mellitus
# KEGG_Pathway	ko05320	Autoimmune thyroid disease
# KEGG_Pathway	ko05330	Allograft rejection
# KEGG_Pathway	ko05332	Graft-versus-host disease
# KEGG_Pathway	ko05416	Viral myocarditis
# MIM	170280	gene
# MIM	603553	phenotype
# Organism	PERF_HUMAN	Homo sapiens (Human)
# Orphanet	391343	Fatal post-viral neurodegenerative disorder
# Orphanet	540	Familial hemophagocytic lymphohistiocytosis
# Orphanet	88	Idiopathic aplastic anemia
# PIR	A45816	A37181
# PROSITE	PS00279	MACPF_1
# PROSITE	PS50004	C2
# PROSITE	PS51412	MACPF_2
# PTM	PERF_HUMAN	N-glycosylated. {ECO 0000250}. 
# Pfam	PF00168	C2
# Pfam	PF01823	MACPF
# Proteomes	UP000005640	Chromosome 10
# RecName	PERF_HUMAN	Perforin-1
# RefSeq	NP_001076585	NM_001083116.1
# RefSeq	NP_005032	NM_005041.4
# SIMILARITY	Belongs to the complement C6/C7/C8/C9 family. {ECO	0000305}. 
# SIMILARITY	Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule	PRU00041}. 
# SIMILARITY	Contains 1 EGF-like domain. {ECO	0000305}. 
# SIMILARITY	Contains 1 MACPF domain. {ECO:0000255|PROSITE- ProRule	PRU00745}. 
# SMART	SM00239	C2
# SMART	SM00457	MACPF
# SUBCELLULAR LOCATION	PERF_HUMAN	Cytoplasmic granule lumen. Secreted. Cell membrane; Multi-pass membrane protein. Endosome lumen. Note=Stored in cytoplasmic granules of cytolytic T-lymphocytes and secreted into the cleft between T-lymphocyte and target cell. Inserts into the cell membrane of target cells and forms pores. Membrane insertion and pore formation requires a major conformation change. May be taken up via endocytosis involving clathrin-coated vesicles and accumulate in a first time in large early endosomes. 
# SUBUNIT	PERF_HUMAN	Monomer, as sobluble protein. Homooligomer. Oligomerization is required for pore formation. {ECO 0000269|PubMed 20889983, ECO 0000269|PubMed 21037563}. 
# SUPFAM	SSF49562	SSF49562
# UCSC	uc001jrf	human
# WEB RESOURCE	PERF_HUMAN	Name=PRF1base; Note=PRF1 mutation db; URL="http //structure.bmc.lu.se/idbase/PRF1base/"; 
# WEB RESOURCE	PERF_HUMAN	Name=Protein Spotlight; Note=Our hollow architecture - Issue 126 of February 2011; URL="http //web.expasy.org/spotlight/back_issues/126";
# WEB RESOURCE	PERF_HUMAN	Name=Wikipedia; Note=Perforin entry; URL="https //en.wikipedia.org/wiki/Perforin"; 
# eggNOG	ENOG410IGJ0	Eukaryota
# eggNOG	ENOG410XSHK	LUCA
BLAST	swissprot:PERF_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:PERF_HUMAN
BioCyc	ZFISH:ENSG00000180644-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000180644-MONOMER
COXPRESdb	5551	http://coxpresdb.jp/data/gene/5551.shtml
CleanEx	HS_PRF1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_PRF1
DIP	DIP-53288N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-53288N
DOI	10.1007/BF02421177	http://dx.doi.org/10.1007/BF02421177
DOI	10.1007/s00109-010-0602-9	http://dx.doi.org/10.1007/s00109-010-0602-9
DOI	10.1016/0161-5890(90)90001-G	http://dx.doi.org/10.1016/0161-5890(90)90001-G
DOI	10.1016/0161-5890(95)00155-7	http://dx.doi.org/10.1016/0161-5890(95)00155-7
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/335448a0	http://dx.doi.org/10.1038/335448a0
DOI	10.1038/nature02462	http://dx.doi.org/10.1038/nature02462
DOI	10.1038/nature09518	http://dx.doi.org/10.1038/nature09518
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M110.169417	http://dx.doi.org/10.1074/jbc.M110.169417
DOI	10.1086/318796	http://dx.doi.org/10.1086/318796
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1126/science.286.5446.1957	http://dx.doi.org/10.1126/science.286.5446.1957
DOI	10.1182/blood-2009-10-246116	http://dx.doi.org/10.1182/blood-2009-10-246116
EMBL	AB209604	http://www.ebi.ac.uk/ena/data/view/AB209604
EMBL	AK312754	http://www.ebi.ac.uk/ena/data/view/AK312754
EMBL	AL355344	http://www.ebi.ac.uk/ena/data/view/AL355344
EMBL	BC047695	http://www.ebi.ac.uk/ena/data/view/BC047695
EMBL	BC063043	http://www.ebi.ac.uk/ena/data/view/BC063043
EMBL	CH471083	http://www.ebi.ac.uk/ena/data/view/CH471083
EMBL	L40557	http://www.ebi.ac.uk/ena/data/view/L40557
EMBL	M28393	http://www.ebi.ac.uk/ena/data/view/M28393
EMBL	M31951	http://www.ebi.ac.uk/ena/data/view/M31951
EMBL	X13224	http://www.ebi.ac.uk/ena/data/view/X13224
Ensembl	ENST00000373209	http://www.ensembl.org/id/ENST00000373209
Ensembl	ENST00000441259	http://www.ensembl.org/id/ENST00000441259
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005576	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016023	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016023
GO_component	GO:0031904	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031904
GO_component	GO:0044194	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044194
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0022829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022829
GO_process	GO:0001771	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001771
GO_process	GO:0002357	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002357
GO_process	GO:0002418	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002418
GO_process	GO:0006915	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006915
GO_process	GO:0006968	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006968
GO_process	GO:0019835	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019835
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:0051607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051607
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005576	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576
GOslim_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0008219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
Gene3D	2.60.40.150	http://www.cathdb.info/version/latest/superfamily/2.60.40.150
GeneCards	PRF1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=PRF1
GeneID	5551	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5551
GeneTree	ENSGT00530000063725	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063725
HGNC	HGNC:9360	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:9360
HOGENOM	HOG000236309	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236309&db=HOGENOM6
HOVERGEN	HBG008168	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG008168&db=HOVERGEN
HPA	CAB002436	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB002436
HPA	HPA037940	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA037940
InParanoid	P14222	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P14222
IntAct	P14222	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P14222*
InterPro	IPR000008	http://www.ebi.ac.uk/interpro/entry/IPR000008
InterPro	IPR020863	http://www.ebi.ac.uk/interpro/entry/IPR020863
InterPro	IPR020864	http://www.ebi.ac.uk/interpro/entry/IPR020864
Jabion	5551	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=5551
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04090	http://www.genome.jp/dbget-bin/www_bget?ko04090
KEGG_Disease	H00109	http://www.genome.jp/dbget-bin/www_bget?H00109
KEGG_Gene	hsa:5551	http://www.genome.jp/dbget-bin/www_bget?hsa:5551
KEGG_Orthology	KO:K07818	http://www.genome.jp/dbget-bin/www_bget?KO:K07818
KEGG_Pathway	ko04650	http://www.genome.jp/kegg-bin/show_pathway?ko04650
KEGG_Pathway	ko04940	http://www.genome.jp/kegg-bin/show_pathway?ko04940
KEGG_Pathway	ko05320	http://www.genome.jp/kegg-bin/show_pathway?ko05320
KEGG_Pathway	ko05330	http://www.genome.jp/kegg-bin/show_pathway?ko05330
KEGG_Pathway	ko05332	http://www.genome.jp/kegg-bin/show_pathway?ko05332
KEGG_Pathway	ko05416	http://www.genome.jp/kegg-bin/show_pathway?ko05416
MIM	170280	http://www.ncbi.nlm.nih.gov/omim/170280
MIM	603553	http://www.ncbi.nlm.nih.gov/omim/603553
MINT	MINT-1401322	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1401322
OMA	NYGTHFI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NYGTHFI
Orphanet	391343	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=391343
Orphanet	540	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=540
Orphanet	88	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=88
OrthoDB	EOG091G03LE	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G03LE
PROSITE	PS00279	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00279
PROSITE	PS50004	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50004
PROSITE	PS51412	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51412
PSORT	swissprot:PERF_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:PERF_HUMAN
PSORT-B	swissprot:PERF_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:PERF_HUMAN
PSORT2	swissprot:PERF_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:PERF_HUMAN
Pfam	PF00168	http://pfam.xfam.org/family/PF00168
Pfam	PF01823	http://pfam.xfam.org/family/PF01823
PharmGKB	PA33732	http://www.pharmgkb.org/do/serve?objId=PA33732&objCls=Gene
Phobius	swissprot:PERF_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:PERF_HUMAN
PhylomeDB	P14222	http://phylomedb.org/?seqid=P14222
ProteinModelPortal	P14222	http://www.proteinmodelportal.org/query/uniprot/P14222
PubMed	10583959	http://www.ncbi.nlm.nih.gov/pubmed/10583959
PubMed	11179007	http://www.ncbi.nlm.nih.gov/pubmed/11179007
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15164054	http://www.ncbi.nlm.nih.gov/pubmed/15164054
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	20038786	http://www.ncbi.nlm.nih.gov/pubmed/20038786
PubMed	20225066	http://www.ncbi.nlm.nih.gov/pubmed/20225066
PubMed	20889983	http://www.ncbi.nlm.nih.gov/pubmed/20889983
PubMed	21037563	http://www.ncbi.nlm.nih.gov/pubmed/21037563
PubMed	2395434	http://www.ncbi.nlm.nih.gov/pubmed/2395434
PubMed	2480391	http://www.ncbi.nlm.nih.gov/pubmed/2480391
PubMed	2592021	http://www.ncbi.nlm.nih.gov/pubmed/2592021
PubMed	3419519	http://www.ncbi.nlm.nih.gov/pubmed/3419519
PubMed	8676885	http://www.ncbi.nlm.nih.gov/pubmed/8676885
PubMed	9058810	http://www.ncbi.nlm.nih.gov/pubmed/9058810
PubMed	9164947	http://www.ncbi.nlm.nih.gov/pubmed/9164947
RefSeq	NP_001076585	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001076585
RefSeq	NP_005032	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005032
SMART	SM00239	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00239
SMART	SM00457	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00457
SMR	P14222	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P14222
STRING	9606.ENSP00000316746	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000316746&targetmode=cogs
SUPFAM	SSF49562	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49562
UCSC	uc001jrf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001jrf&org=rat
UniGene	Hs.2200	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.2200
UniProtKB	PERF_HUMAN	http://www.uniprot.org/uniprot/PERF_HUMAN
UniProtKB-AC	P14222	http://www.uniprot.org/uniprot/P14222
charge	swissprot:PERF_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:PERF_HUMAN
eggNOG	ENOG410IGJ0	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IGJ0
eggNOG	ENOG410XSHK	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSHK
epestfind	swissprot:PERF_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:PERF_HUMAN
garnier	swissprot:PERF_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:PERF_HUMAN
helixturnhelix	swissprot:PERF_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:PERF_HUMAN
hmoment	swissprot:PERF_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:PERF_HUMAN
iep	swissprot:PERF_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:PERF_HUMAN
inforesidue	swissprot:PERF_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:PERF_HUMAN
neXtProt	NX_P14222	http://www.nextprot.org/db/entry/NX_P14222
octanol	swissprot:PERF_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:PERF_HUMAN
pepcoil	swissprot:PERF_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:PERF_HUMAN
pepdigest	swissprot:PERF_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:PERF_HUMAN
pepinfo	swissprot:PERF_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:PERF_HUMAN
pepnet	swissprot:PERF_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:PERF_HUMAN
pepstats	swissprot:PERF_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:PERF_HUMAN
pepwheel	swissprot:PERF_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:PERF_HUMAN
pepwindow	swissprot:PERF_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:PERF_HUMAN
sigcleave	swissprot:PERF_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:PERF_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SO2B1_HUMAN	Event=Alternative promoter usage, Alternative splicing; Named isoforms=4; Name=1; Synonyms=1b, FL; IsoId=O94956-1; Sequence=Displayed; Name=2; IsoId=O94956-2; Sequence=VSP_006147, VSP_006148; Note=No experimental confirmation available.; Name=3; Synonyms=1e, Short; IsoId=O94956-3; Sequence=VSP_054109; Note=Functional transporter. Predominant isoform in liver, expression at promoter is regulated by HNF4alpha.; Name=4; IsoId=O94956-4; Sequence=VSP_054110; Note=No experimental confirmation available.; 
# AltName	SO2B1_HUMAN	Organic anion transporter B
# AltName	SO2B1_HUMAN	Organic anion transporter polypeptide-related protein 2
# AltName	SO2B1_HUMAN	Solute carrier family 21 member 9
# CCDS	CCDS44683	-. [O94956-3]
# CCDS	CCDS53679	-. [O94956-4]
# CCDS	CCDS8235	-. [O94956-1]
# CDD	cd06174	MFS
# ChiTaRS	SLCO2B1	human
# DrugBank	DB00175	Pravastatin
# DrugBank	DB00286	Conjugated Estrogens
# DrugBank	DB00390	Digoxin
# DrugBank	DB00471	Montelukast
# DrugBank	DB00627	Niacin
# DrugBank	DB00654	Latanoprost
# DrugBank	DB00655	Estrone
# DrugBank	DB00770	Alprostadil
# DrugBank	DB00783	Estradiol
# DrugBank	DB00917	Dinoprostone
# DrugBank	DB00936	Salicylic acid
# DrugBank	DB00950	Fexofenadine
# DrugBank	DB01016	Glyburide
# DrugBank	DB01045	Rifampicin
# DrugBank	DB01049	Ergoloid mesylate
# DrugBank	DB01050	Ibuprofen
# DrugBank	DB01053	Benzylpenicillin
# DrugBank	DB01076	Atorvastatin
# DrugBank	DB01088	Iloprost
# DrugBank	DB01095	Fluvastatin
# DrugBank	DB01098	Rosuvastatin
# DrugBank	DB01124	Tolbutamide
# DrugBank	DB03166	Acetic acid
# DrugBank	DB03793	Benzoic Acid
# DrugBank	DB04398	Lactic Acid
# DrugBank	DB08860	Pitavastatin
# Ensembl	ENST00000428359	ENSP00000388912; ENSG00000137491
# Ensembl	ENST00000454962	ENSP00000389653; ENSG00000137491
# ExpressionAtlas	O94956	baseline and differential
# FUNCTION	SO2B1_HUMAN	Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0008514	organic anion transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015125	bile acid transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015347	sodium-independent organic anion transmembrane transporter activity; IDA:UniProtKB.
# GO_process	GO:0015721	bile acid and bile salt transport; IBA:GO_Central.
# GO_process	GO:0043252	sodium-independent organic anion transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	O94956	HS
# HGNC	HGNC:10962	SLCO2B1
# InterPro	IPR002350	Kazal_dom
# InterPro	IPR004156	OA_transporter
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02001	Solute carrier family
# MIM	604988	gene
# Organism	SO2B1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11388	PTHR11388
# PIR	T17250	T17250
# PROSITE	PS51465	KAZAL_2
# Pfam	PF03137	OATP
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-879518	Transport of organic anions
# RecName	SO2B1_HUMAN	Solute carrier organic anion transporter family member 2B1
# RefSeq	NP_001138683	NM_001145211.2
# RefSeq	NP_001138684	NM_001145212.2
# RefSeq	NP_009187	NM_007256.4
# SEQUENCE CAUTION	Sequence=BAA74903.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the organo anion transporter (TC 2.A.60) family. {ECO	0000305}. 
# SIMILARITY	Contains 1 Kazal-like domain. {ECO:0000255|PROSITE- ProRule	PRU00798}. 
# SUBCELLULAR LOCATION	SO2B1_HUMAN	Cell membrane; Multi-pass membrane protein. 
# SUPFAM	SSF103473	SSF103473; 5
# TCDB	2.A.60.1.20	the organo anion transporter (oat) family
# TIGRFAMs	TIGR00805	oat
# TISSUE SPECIFICITY	Isoform 1 has it's highest expression in brain, it is the major form expressed in duodenum, kidney, placenta, and skeletal muscle. Isoform 3 predominates in liver. {ECO:0000269|PubMed	23531488}. 
# UCSC	uc001owc	human. [O94956-1]
# eggNOG	ENOG410XRSF	LUCA
# eggNOG	KOG3626	Eukaryota
BLAST	swissprot:SO2B1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SO2B1_HUMAN
BioCyc	ZFISH:ENSG00000137491-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000137491-MONOMER
COXPRESdb	11309	http://coxpresdb.jp/data/gene/11309.shtml
CleanEx	HS_SLCO2B1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLCO2B1
DOI	10.1006/bbrc.2000.2922	http://dx.doi.org/10.1006/bbrc.2000.2922
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/dnares/5.6.355	http://dx.doi.org/10.1093/dnares/5.6.355
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1124/mol.105.019547	http://dx.doi.org/10.1124/mol.105.019547
DOI	10.1124/mol.112.083618	http://dx.doi.org/10.1124/mol.112.083618
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DrugBank	DB00175	http://www.drugbank.ca/drugs/DB00175
DrugBank	DB00286	http://www.drugbank.ca/drugs/DB00286
DrugBank	DB00390	http://www.drugbank.ca/drugs/DB00390
DrugBank	DB00471	http://www.drugbank.ca/drugs/DB00471
DrugBank	DB00627	http://www.drugbank.ca/drugs/DB00627
DrugBank	DB00654	http://www.drugbank.ca/drugs/DB00654
DrugBank	DB00655	http://www.drugbank.ca/drugs/DB00655
DrugBank	DB00770	http://www.drugbank.ca/drugs/DB00770
DrugBank	DB00783	http://www.drugbank.ca/drugs/DB00783
DrugBank	DB00917	http://www.drugbank.ca/drugs/DB00917
DrugBank	DB00936	http://www.drugbank.ca/drugs/DB00936
DrugBank	DB00950	http://www.drugbank.ca/drugs/DB00950
DrugBank	DB01016	http://www.drugbank.ca/drugs/DB01016
DrugBank	DB01045	http://www.drugbank.ca/drugs/DB01045
DrugBank	DB01049	http://www.drugbank.ca/drugs/DB01049
DrugBank	DB01050	http://www.drugbank.ca/drugs/DB01050
DrugBank	DB01053	http://www.drugbank.ca/drugs/DB01053
DrugBank	DB01076	http://www.drugbank.ca/drugs/DB01076
DrugBank	DB01088	http://www.drugbank.ca/drugs/DB01088
DrugBank	DB01095	http://www.drugbank.ca/drugs/DB01095
DrugBank	DB01098	http://www.drugbank.ca/drugs/DB01098
DrugBank	DB01124	http://www.drugbank.ca/drugs/DB01124
DrugBank	DB03166	http://www.drugbank.ca/drugs/DB03166
DrugBank	DB03793	http://www.drugbank.ca/drugs/DB03793
DrugBank	DB04398	http://www.drugbank.ca/drugs/DB04398
DrugBank	DB08860	http://www.drugbank.ca/drugs/DB08860
EMBL	AB020687	http://www.ebi.ac.uk/ena/data/view/AB020687
EMBL	AB026256	http://www.ebi.ac.uk/ena/data/view/AB026256
EMBL	AF205073	http://www.ebi.ac.uk/ena/data/view/AF205073
EMBL	AK290234	http://www.ebi.ac.uk/ena/data/view/AK290234
EMBL	AK294503	http://www.ebi.ac.uk/ena/data/view/AK294503
EMBL	AK300134	http://www.ebi.ac.uk/ena/data/view/AK300134
EMBL	AL117465	http://www.ebi.ac.uk/ena/data/view/AL117465
EMBL	AP001972	http://www.ebi.ac.uk/ena/data/view/AP001972
EMBL	BC041095	http://www.ebi.ac.uk/ena/data/view/BC041095
Ensembl	ENST00000428359	http://www.ensembl.org/id/ENST00000428359
Ensembl	ENST00000454962	http://www.ensembl.org/id/ENST00000454962
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0008514	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008514
GO_function	GO:0015125	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015125
GO_function	GO:0015347	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015347
GO_process	GO:0015721	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015721
GO_process	GO:0043252	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043252
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLCO2B1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLCO2B1
GeneID	11309	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11309
HGNC	HGNC:10962	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10962
HOGENOM	HOG000231269	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231269&db=HOGENOM6
HOVERGEN	HBG108345	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108345&db=HOVERGEN
HPA	HPA020659	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA020659
InParanoid	O94956	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O94956
InterPro	IPR002350	http://www.ebi.ac.uk/interpro/entry/IPR002350
InterPro	IPR004156	http://www.ebi.ac.uk/interpro/entry/IPR004156
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	11309	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=11309
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:11309	http://www.genome.jp/dbget-bin/www_bget?hsa:11309
KEGG_Orthology	KO:K14352	http://www.genome.jp/dbget-bin/www_bget?KO:K14352
MIM	604988	http://www.ncbi.nlm.nih.gov/omim/604988
PANTHER	PTHR11388	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11388
PROSITE	PS51465	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51465
PSORT	swissprot:SO2B1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SO2B1_HUMAN
PSORT-B	swissprot:SO2B1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SO2B1_HUMAN
PSORT2	swissprot:SO2B1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SO2B1_HUMAN
Pfam	PF03137	http://pfam.xfam.org/family/PF03137
PharmGKB	PA35845	http://www.pharmgkb.org/do/serve?objId=PA35845&objCls=Gene
Phobius	swissprot:SO2B1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SO2B1_HUMAN
PhylomeDB	O94956	http://phylomedb.org/?seqid=O94956
ProteinModelPortal	O94956	http://www.proteinmodelportal.org/query/uniprot/O94956
PubMed	10048485	http://www.ncbi.nlm.nih.gov/pubmed/10048485
PubMed	10873595	http://www.ncbi.nlm.nih.gov/pubmed/10873595
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	16754786	http://www.ncbi.nlm.nih.gov/pubmed/16754786
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	23531488	http://www.ncbi.nlm.nih.gov/pubmed/23531488
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
Reactome	R-HSA-879518	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-879518
RefSeq	NP_001138683	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001138683
RefSeq	NP_001138684	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001138684
RefSeq	NP_009187	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_009187
STRING	9606.ENSP00000289575	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000289575&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.60.1.20	http://www.tcdb.org/search/result.php?tc=2.A.60.1.20
TIGRFAMs	TIGR00805	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00805
UCSC	uc001owc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001owc&org=rat
UniGene	Hs.7884	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.7884
UniProtKB	SO2B1_HUMAN	http://www.uniprot.org/uniprot/SO2B1_HUMAN
UniProtKB-AC	O94956	http://www.uniprot.org/uniprot/O94956
charge	swissprot:SO2B1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SO2B1_HUMAN
eggNOG	ENOG410XRSF	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRSF
eggNOG	KOG3626	http://eggnogapi.embl.de/nog_data/html/tree/KOG3626
epestfind	swissprot:SO2B1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SO2B1_HUMAN
garnier	swissprot:SO2B1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SO2B1_HUMAN
helixturnhelix	swissprot:SO2B1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SO2B1_HUMAN
hmoment	swissprot:SO2B1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SO2B1_HUMAN
iep	swissprot:SO2B1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SO2B1_HUMAN
inforesidue	swissprot:SO2B1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SO2B1_HUMAN
neXtProt	NX_O94956	http://www.nextprot.org/db/entry/NX_O94956
octanol	swissprot:SO2B1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SO2B1_HUMAN
pepcoil	swissprot:SO2B1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SO2B1_HUMAN
pepdigest	swissprot:SO2B1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SO2B1_HUMAN
pepinfo	swissprot:SO2B1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SO2B1_HUMAN
pepnet	swissprot:SO2B1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SO2B1_HUMAN
pepstats	swissprot:SO2B1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SO2B1_HUMAN
pepwheel	swissprot:SO2B1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SO2B1_HUMAN
pepwindow	swissprot:SO2B1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SO2B1_HUMAN
sigcleave	swissprot:SO2B1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SO2B1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	NLS1_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8NA29-1; Sequence=Displayed; Name=2; IsoId=Q8NA29-2; Sequence=VSP_022539; Name=3; IsoId=Q8NA29-3; Sequence=VSP_022540; Note=No experimental confirmation available.; 
# AltName	NLS1_HUMAN	Major facilitator superfamily domain-containing protein 2A
# CCDS	CCDS44118	-. [Q8NA29-1]
# CCDS	CCDS446	-. [Q8NA29-2]
# ChiTaRS	MFSD2A	human
# DISEASE	NLS1_HUMAN	Microcephaly 15, primary, autosomal recessive (MCPH15) [MIM 616486]  A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age, sex and ethnically matched mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. {ECO 0000269|PubMed 26005865, ECO 0000269|PubMed 26005868}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000372809	ENSP00000361895; ENSG00000168389. [Q8NA29-1]
# Ensembl	ENST00000372811	ENSP00000361898; ENSG00000168389. [Q8NA29-2]
# ExpressionAtlas	Q8NA29	baseline and differential
# FUNCTION	NLS1_HUMAN	Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega- 3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid. Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport. Not required for central nervous system vascular morphogenesis (By similarity). Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation. In placenta, acts as a receptor for ERVFRD- 1/syncytin-2 and is required for trophoblast fusion (PubMed 18988732). {ECO 0000250|UniProtKB Q9DA75, ECO 0000269|PubMed 18988732, ECO 0000269|PubMed 21677192, ECO 0000269|PubMed 23177091, ECO 0000269|PubMed 26005868}. 
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0005789	endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; IDA:HPA.
# GO_component	GO:0005887	integral component of plasma membrane; ISS:UniProtKB.
# GO_function	GO:0005548	phospholipid transporter activity; ISS:UniProtKB.
# GO_function	GO:0015245	fatty acid transporter activity; ISS:BHF-UCL.
# GO_function	GO:0015293	symporter activity; ISS:UniProtKB.
# GO_function	GO:0051978	lysophospholipid transporter activity; IDA:BHF-UCL.
# GO_process	GO:0015908	fatty acid transport; ISS:UniProtKB.
# GO_process	GO:0021766	hippocampus development; ISS:BHF-UCL.
# GO_process	GO:0045056	transcytosis; ISS:UniProtKB.
# GO_process	GO:0051977	lysophospholipid transport; IDA:BHF-UCL.
# GO_process	GO:0060856	establishment of blood-brain barrier; ISS:UniProtKB.
# GO_process	GO:1990379	lipid transport across blood brain barrier; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0048856	anatomical structure development
# Genevisible	Q8NA29	HS
# HGNC	HGNC:25897	MFSD2A
# InterPro	IPR020846	MFS_dom
# MIM	614397	gene
# MIM	616486	phenotype
# Organism	NLS1_HUMAN	Homo sapiens (Human)
# PTM	NLS1_HUMAN	N-glycosylated. {ECO 0000269|PubMed 21677192}. 
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-1483191	Synthesis of PC
# RecName	NLS1_HUMAN	Sodium-dependent lysophosphatidylcholine symporter 1
# RefSeq	NP_001129965	NM_001136493.2. [Q8NA29-1]
# RefSeq	NP_001274737	NM_001287808.1
# RefSeq	NP_001274738	NM_001287809.1
# RefSeq	NP_116182	NM_032793.4. [Q8NA29-2]
# SIMILARITY	Belongs to the major facilitator superfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	NLS1_HUMAN	Cell membrane {ECO 0000269|PubMed 26005868}; Multi-pass membrane protein {ECO 0000255}. Endoplasmic reticulum membrane {ECO 0000250|UniProtKB Q9DA75}; Multi-pass membrane protein {ECO 0000255}. Note=Cytoplasmic punctae that may represent vesicles shuttling between the endoplasmic reticulum and the plasma membrane (PubMed 21677192). {ECO 0000269|PubMed 21677192}. 
# SUBUNIT	Interacts with ERVFRD-1/syncytin-2. {ECO:0000269|PubMed	18988732}. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.2.3:the glycoside-pentoside-hexuronide (gph)	cation symporter family
# TISSUE SPECIFICITY	In placenta, associated with trophoblast cells. {ECO:0000269|PubMed	18988732}. 
# UCSC	uc001ceu	human. [Q8NA29-1]
# eggNOG	COG2211	LUCA
# eggNOG	KOG4830	Eukaryota
BLAST	swissprot:NLS1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NLS1_HUMAN
BioCyc	ZFISH:ENSG00000168389-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000168389-MONOMER
COXPRESdb	84879	http://coxpresdb.jp/data/gene/84879.shtml
CleanEx	HS_MFSD2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_MFSD2
DIP	DIP-47306N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47306N
DOI	10.1016/j.placenta.2012.10.012	http://dx.doi.org/10.1016/j.placenta.2012.10.012
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng.3311	http://dx.doi.org/10.1038/ng.3311
DOI	10.1038/ng.3313	http://dx.doi.org/10.1038/ng.3313
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.onc.1207782	http://dx.doi.org/10.1038/sj.onc.1207782
DOI	10.1042/BJ20080165	http://dx.doi.org/10.1042/BJ20080165
DOI	10.1073/pnas.0404089101	http://dx.doi.org/10.1073/pnas.0404089101
DOI	10.1073/pnas.0807413105	http://dx.doi.org/10.1073/pnas.0807413105
DOI	10.1073/pnas.1018098108	http://dx.doi.org/10.1073/pnas.1018098108
DOI	10.1093/dnares/12.2.117	http://dx.doi.org/10.1093/dnares/12.2.117
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB073383	http://www.ebi.ac.uk/ena/data/view/AB073383
EMBL	AF289609	http://www.ebi.ac.uk/ena/data/view/AF289609
EMBL	AK075183	http://www.ebi.ac.uk/ena/data/view/AK075183
EMBL	AK093223	http://www.ebi.ac.uk/ena/data/view/AK093223
EMBL	AK291540	http://www.ebi.ac.uk/ena/data/view/AK291540
EMBL	AL663070	http://www.ebi.ac.uk/ena/data/view/AL663070
EMBL	AL663070	http://www.ebi.ac.uk/ena/data/view/AL663070
EMBL	AY358636	http://www.ebi.ac.uk/ena/data/view/AY358636
EMBL	BC006353	http://www.ebi.ac.uk/ena/data/view/BC006353
EMBL	BC011587	http://www.ebi.ac.uk/ena/data/view/BC011587
EMBL	BC092414	http://www.ebi.ac.uk/ena/data/view/BC092414
EMBL	CH471059	http://www.ebi.ac.uk/ena/data/view/CH471059
Ensembl	ENST00000372809	http://www.ensembl.org/id/ENST00000372809
Ensembl	ENST00000372811	http://www.ensembl.org/id/ENST00000372811
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005548	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005548
GO_function	GO:0015245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015245
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_function	GO:0051978	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051978
GO_process	GO:0015908	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015908
GO_process	GO:0021766	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021766
GO_process	GO:0045056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045056
GO_process	GO:0051977	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051977
GO_process	GO:0060856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060856
GO_process	GO:1990379	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990379
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GeneCards	MFSD2A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=MFSD2A
GeneID	84879	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84879
GeneTree	ENSGT00390000005318	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000005318
HGNC	HGNC:25897	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:25897
HOGENOM	HOG000294186	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294186&db=HOGENOM6
HOVERGEN	HBG080097	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG080097&db=HOVERGEN
HPA	HPA043107	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA043107
InParanoid	Q8NA29	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8NA29
IntAct	Q8NA29	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8NA29*
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	84879	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=84879
KEGG_Gene	hsa:84879	http://www.genome.jp/dbget-bin/www_bget?hsa:84879
MIM	614397	http://www.ncbi.nlm.nih.gov/omim/614397
MIM	616486	http://www.ncbi.nlm.nih.gov/omim/616486
OMA	AWISSIV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AWISSIV
OrthoDB	EOG091G06N1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G06N1
PSORT	swissprot:NLS1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NLS1_HUMAN
PSORT-B	swissprot:NLS1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NLS1_HUMAN
PSORT2	swissprot:NLS1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NLS1_HUMAN
PharmGKB	PA165751549	http://www.pharmgkb.org/do/serve?objId=PA165751549&objCls=Gene
Phobius	swissprot:NLS1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NLS1_HUMAN
PhylomeDB	Q8NA29	http://phylomedb.org/?seqid=Q8NA29
ProteinModelPortal	Q8NA29	http://www.proteinmodelportal.org/query/uniprot/Q8NA29
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15221005	http://www.ncbi.nlm.nih.gov/pubmed/15221005
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15498874	http://www.ncbi.nlm.nih.gov/pubmed/15498874
PubMed	16303743	http://www.ncbi.nlm.nih.gov/pubmed/16303743
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	18694395	http://www.ncbi.nlm.nih.gov/pubmed/18694395
PubMed	18988732	http://www.ncbi.nlm.nih.gov/pubmed/18988732
PubMed	21677192	http://www.ncbi.nlm.nih.gov/pubmed/21677192
PubMed	23177091	http://www.ncbi.nlm.nih.gov/pubmed/23177091
PubMed	26005865	http://www.ncbi.nlm.nih.gov/pubmed/26005865
PubMed	26005868	http://www.ncbi.nlm.nih.gov/pubmed/26005868
Reactome	R-HSA-1483191	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1483191
RefSeq	NP_001129965	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001129965
RefSeq	NP_001274737	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001274737
RefSeq	NP_001274738	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001274738
RefSeq	NP_116182	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_116182
STRING	9606.ENSP00000361895	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000361895&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.2.3	http://www.tcdb.org/search/result.php?tc=2.A.2.3
UCSC	uc001ceu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001ceu&org=rat
UniGene	Hs.655177	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.655177
UniProtKB	NLS1_HUMAN	http://www.uniprot.org/uniprot/NLS1_HUMAN
UniProtKB-AC	Q8NA29	http://www.uniprot.org/uniprot/Q8NA29
charge	swissprot:NLS1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NLS1_HUMAN
eggNOG	COG2211	http://eggnogapi.embl.de/nog_data/html/tree/COG2211
eggNOG	KOG4830	http://eggnogapi.embl.de/nog_data/html/tree/KOG4830
epestfind	swissprot:NLS1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NLS1_HUMAN
garnier	swissprot:NLS1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NLS1_HUMAN
helixturnhelix	swissprot:NLS1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NLS1_HUMAN
hmoment	swissprot:NLS1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NLS1_HUMAN
iep	swissprot:NLS1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NLS1_HUMAN
inforesidue	swissprot:NLS1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NLS1_HUMAN
neXtProt	NX_Q8NA29	http://www.nextprot.org/db/entry/NX_Q8NA29
octanol	swissprot:NLS1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NLS1_HUMAN
pepcoil	swissprot:NLS1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NLS1_HUMAN
pepdigest	swissprot:NLS1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NLS1_HUMAN
pepinfo	swissprot:NLS1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NLS1_HUMAN
pepnet	swissprot:NLS1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NLS1_HUMAN
pepstats	swissprot:NLS1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NLS1_HUMAN
pepwheel	swissprot:NLS1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NLS1_HUMAN
pepwindow	swissprot:NLS1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NLS1_HUMAN
sigcleave	swissprot:NLS1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NLS1_HUMAN
## Database	ID	URL or Descriptions
# AltName	SC5A8_HUMAN	Apical iodide transporter
# AltName	SC5A8_HUMAN	Electrogenic sodium monocarboxylate cotransporter
# AltName	SC5A8_HUMAN	Sodium iodide-related cotransporter
# AltName	SC5A8_HUMAN	Solute carrier family 5 member 8
# BIOPHYSICOCHEMICAL PROPERTIES	SC5A8_HUMAN	Kinetic parameters  KM=1442 uM for beta-D-hydroxybutyate {ECO 0000269|PubMed 16805814}; KM=2327 uM for beta-L-hydroxybutyate {ECO 0000269|PubMed 16805814}; KM=1088 uM for D-lactate {ECO 0000269|PubMed 16805814}; KM=184 uM for L-lactate {ECO 0000269|PubMed 16805814}; KM=387 uM for pyruvate {ECO 0000269|PubMed 16805814}; KM=213 uM for acetoacetate {ECO 0000269|PubMed 16805814}; KM=209 uM for alpha-ketoisocaproate {ECO 0000269|PubMed 16805814}; 
# BioGrid	127763	21
# DrugBank	DB00627	Niacin
# DrugBank	DB08872	gabapentin enacarbil
# Ensembl	ENST00000536262	ENSP00000445340; ENSG00000256870
# Ensembl	ENST00000572861	ENSP00000461697; ENSG00000262217
# FUNCTION	SC5A8_HUMAN	Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D- hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+) substrate stoichiometry of between 4 1 and 2 1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D- lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons. {ECO 0000269|PubMed 12107270, ECO 0000269|PubMed 12829793, ECO 0000269|PubMed 14966140, ECO 0000269|PubMed 15090606, ECO 0000269|PubMed 15361710, ECO 0000269|PubMed 15867356, ECO 0000269|PubMed 16729224, ECO 0000269|PubMed 16805814, ECO 0000269|PubMed 17178845, ECO 0000269|PubMed 17245649, ECO 0000269|PubMed 18037591}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016324	apical plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0008028	monocarboxylic acid transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015293	symporter activity; IBA:GO_Central.
# GO_function	GO:0022803	passive transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006814	sodium ion transport; IEA:UniProtKB-KW.
# GO_process	GO:0006915	apoptotic process; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008219	cell death
# Genevisible	Q8N695	HS
# HGNC	HGNC:19119	SLC5A8
# INDUCTION	SC5A8_HUMAN	Down-regulated in some primary cancers; due to aberrant methylation in primary colon cancers, astrocytomas and oligodendrogliomas as well as in cancers of the colon, prostate and gastric regions, and glial cell lines. Expression reactivated on treatment with a demethylating drug, 5-azacytidine. {ECO 0000269|PubMed 12829793, ECO 0000269|PubMed 15361710, ECO 0000269|PubMed 15867356, ECO 0000269|PubMed 18037591}. 
# InterPro	IPR001734	Na/solute_symporter
# KEGG_Brite	ko02001	Solute carrier family
# MIM	608044	gene
# MISCELLANEOUS	SC5A8_HUMAN	Increase of iodide influx inhibited by addition of perchlorate (NaClO(4)), a competitive inhibitor of iodide uptake catalyzed by sodium iodide symporter (NIS). Cotransport of monocarboxylates and nicotinate strongly inhibited by probenecid, nonsteroid anti-inflammatory drugs (ibuprofen, fenoprofen, ketprofen, naproxen) in a Na(+)-dependent manner or by prolonged exposure to external concentrations of monocarboxylates. 
# Organism	SC5A8_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11819	PTHR11819; 2
# PROSITE	PS50283	NA_SOLUT_SYMP_3
# Pfam	PF00474	SSF
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-428643	Organic anion transporters
# RecName	SC5A8_HUMAN	Sodium-coupled monocarboxylate transporter 1
# RefSeq	NP_666018	NM_145913.3
# SIMILARITY	Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. {ECO	0000255}. 
# SUBCELLULAR LOCATION	SC5A8_HUMAN	Apical cell membrane {ECO 0000269|PubMed 12107270, ECO 0000269|PubMed 15001644, ECO 0000269|PubMed 17245649}; Multi-pass membrane protein {ECO 0000269|PubMed 12107270, ECO 0000269|PubMed 15001644, ECO 0000269|PubMed 17245649}. Note=Expressed at the apical membrane of normal tall thyrocytes and of colonic epithelial cells. {ECO 0000269|PubMed 12107270, ECO 0000269|PubMed 15001644, ECO 0000269|PubMed 17245649}. 
# TCDB	2.A.21.5:the solute	sodium symporter (sss) family
# TIGRFAMs	TIGR00813	sss
# TISSUE SPECIFICITY	SC5A8_HUMAN	Expressed in normal thyroid, localized at the apical pole of thyroid cells facing the colloid lumen, but expression profoundly decreased in thyroid carcinomas. Expressed in normal colon but absent in colon aberrant crypt foci and colon cancers. Present in normal kidney cortex, brain, prostate, gastric mucosa and breast tissue but was significantly down-regulated in primary gliomas, gastric cancer, prostate tumors and breast tumors. {ECO 0000269|PubMed 12107270, ECO 0000269|PubMed 12829793, ECO 0000269|PubMed 14966140, ECO 0000269|PubMed 15001644, ECO 0000269|PubMed 15090606, ECO 0000269|PubMed 15361710, ECO 0000269|PubMed 15867356, ECO 0000269|PubMed 17178845, ECO 0000269|PubMed 17245649, ECO 0000269|PubMed 18037591}. 
# UCSC	uc001thz	human
# WEB RESOURCE	SC5A8_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/SLC5A8ID44089ch12q23.html";
# eggNOG	COG0591	LUCA
# eggNOG	KOG2349	Eukaryota
BLAST	swissprot:SC5A8_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SC5A8_HUMAN
BioCyc	ZFISH:ENSG00000139357-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000139357-MONOMER
COXPRESdb	160728	http://coxpresdb.jp/data/gene/160728.shtml
CleanEx	HS_SLC5A8	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC5A8
DOI	10.1007/s11095-006-0023-1	http://dx.doi.org/10.1007/s11095-006-0023-1
DOI	10.1007/s11095-006-9176-1	http://dx.doi.org/10.1007/s11095-006-9176-1
DOI	10.1016/j.cdp.2007.09.002	http://dx.doi.org/10.1016/j.cdp.2007.09.002
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1073/pnas.1430846100	http://dx.doi.org/10.1073/pnas.1430846100
DOI	10.1074/jbc.C400059200	http://dx.doi.org/10.1074/jbc.C400059200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1471-4159.2006.03878.x	http://dx.doi.org/10.1111/j.1471-4159.2006.03878.x
DOI	10.1113/jphysiol.2004.063859	http://dx.doi.org/10.1113/jphysiol.2004.063859
DOI	10.1158/0008-5472.CAN-05-0048	http://dx.doi.org/10.1158/0008-5472.CAN-05-0048
DOI	10.1158/0008-5472.CAN-06-1950	http://dx.doi.org/10.1158/0008-5472.CAN-06-1950
DOI	10.1159/000079145	http://dx.doi.org/10.1159/000079145
DOI	10.1210/jc.2003-030542	http://dx.doi.org/10.1210/jc.2003-030542
DOI	10.1210/jcem.87.7.8797	http://dx.doi.org/10.1210/jcem.87.7.8797
DrugBank	DB00627	http://www.drugbank.ca/drugs/DB00627
DrugBank	DB08872	http://www.drugbank.ca/drugs/DB08872
EMBL	AC079953	http://www.ebi.ac.uk/ena/data/view/AC079953
EMBL	AF536216	http://www.ebi.ac.uk/ena/data/view/AF536216
EMBL	AF536217	http://www.ebi.ac.uk/ena/data/view/AF536217
EMBL	AY081220	http://www.ebi.ac.uk/ena/data/view/AY081220
EMBL	BC110492	http://www.ebi.ac.uk/ena/data/view/BC110492
EMBL	CH471054	http://www.ebi.ac.uk/ena/data/view/CH471054
Ensembl	ENST00000536262	http://www.ensembl.org/id/ENST00000536262
Ensembl	ENST00000572861	http://www.ensembl.org/id/ENST00000572861
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0008028	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008028
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_function	GO:0022803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022803
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0006915	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006915
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219
GeneCards	SLC5A8	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC5A8
GeneID	160728	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=160728
GeneTree	ENSGT00760000118955	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118955
H-InvDB	HIX0036731	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0036731
HGNC	HGNC:19119	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:19119
HOGENOM	HOG000261662	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261662&db=HOGENOM6
HOVERGEN	HBG057280	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG057280&db=HOVERGEN
InParanoid	Q8N695	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8N695
IntAct	Q8N695	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8N695*
InterPro	IPR001734	http://www.ebi.ac.uk/interpro/entry/IPR001734
Jabion	160728	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=160728
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:160728	http://www.genome.jp/dbget-bin/www_bget?hsa:160728
KEGG_Orthology	KO:K14388	http://www.genome.jp/dbget-bin/www_bget?KO:K14388
MIM	608044	http://www.ncbi.nlm.nih.gov/omim/608044
OMA	DILQDFP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DILQDFP
OrthoDB	EOG091G07OC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07OC
PANTHER	PTHR11819	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11819
PROSITE	PS50283	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50283
PSORT	swissprot:SC5A8_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SC5A8_HUMAN
PSORT-B	swissprot:SC5A8_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SC5A8_HUMAN
PSORT2	swissprot:SC5A8_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SC5A8_HUMAN
Pfam	PF00474	http://pfam.xfam.org/family/PF00474
PharmGKB	PA134989874	http://www.pharmgkb.org/do/serve?objId=PA134989874&objCls=Gene
Phobius	swissprot:SC5A8_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SC5A8_HUMAN
PhylomeDB	Q8N695	http://phylomedb.org/?seqid=Q8N695
ProteinModelPortal	Q8N695	http://www.proteinmodelportal.org/query/uniprot/Q8N695
PubMed	12107270	http://www.ncbi.nlm.nih.gov/pubmed/12107270
PubMed	12829793	http://www.ncbi.nlm.nih.gov/pubmed/12829793
PubMed	14966140	http://www.ncbi.nlm.nih.gov/pubmed/14966140
PubMed	15001644	http://www.ncbi.nlm.nih.gov/pubmed/15001644
PubMed	15090606	http://www.ncbi.nlm.nih.gov/pubmed/15090606
PubMed	15361710	http://www.ncbi.nlm.nih.gov/pubmed/15361710
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15867356	http://www.ncbi.nlm.nih.gov/pubmed/15867356
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	16729224	http://www.ncbi.nlm.nih.gov/pubmed/16729224
PubMed	16805814	http://www.ncbi.nlm.nih.gov/pubmed/16805814
PubMed	17178845	http://www.ncbi.nlm.nih.gov/pubmed/17178845
PubMed	17245649	http://www.ncbi.nlm.nih.gov/pubmed/17245649
PubMed	18037591	http://www.ncbi.nlm.nih.gov/pubmed/18037591
Reactome	R-HSA-428643	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428643
RefSeq	NP_666018	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_666018
STRING	9606.ENSP00000445340	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000445340&targetmode=cogs
TCDB	2.A.21.5	http://www.tcdb.org/search/result.php?tc=2.A.21.5
TIGRFAMs	TIGR00813	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00813
UCSC	uc001thz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001thz&org=rat
UniGene	Hs.444536	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.444536
UniProtKB	SC5A8_HUMAN	http://www.uniprot.org/uniprot/SC5A8_HUMAN
UniProtKB-AC	Q8N695	http://www.uniprot.org/uniprot/Q8N695
charge	swissprot:SC5A8_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SC5A8_HUMAN
eggNOG	COG0591	http://eggnogapi.embl.de/nog_data/html/tree/COG0591
eggNOG	KOG2349	http://eggnogapi.embl.de/nog_data/html/tree/KOG2349
epestfind	swissprot:SC5A8_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SC5A8_HUMAN
garnier	swissprot:SC5A8_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SC5A8_HUMAN
helixturnhelix	swissprot:SC5A8_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SC5A8_HUMAN
hmoment	swissprot:SC5A8_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SC5A8_HUMAN
iep	swissprot:SC5A8_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SC5A8_HUMAN
inforesidue	swissprot:SC5A8_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SC5A8_HUMAN
neXtProt	NX_Q8N695	http://www.nextprot.org/db/entry/NX_Q8N695
octanol	swissprot:SC5A8_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SC5A8_HUMAN
pepcoil	swissprot:SC5A8_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SC5A8_HUMAN
pepdigest	swissprot:SC5A8_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SC5A8_HUMAN
pepinfo	swissprot:SC5A8_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SC5A8_HUMAN
pepnet	swissprot:SC5A8_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SC5A8_HUMAN
pepstats	swissprot:SC5A8_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SC5A8_HUMAN
pepwheel	swissprot:SC5A8_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SC5A8_HUMAN
pepwindow	swissprot:SC5A8_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SC5A8_HUMAN
sigcleave	swissprot:SC5A8_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SC5A8_HUMAN
## Database	ID	URL or Descriptions
# AltName	AP3S1_HUMAN	AP-3 complex subunit sigma-3A
# AltName	AP3S1_HUMAN	Adaptor-related protein complex 3 subunit sigma-1
# AltName	AP3S1_HUMAN	Clathrin-associated/assembly/adaptor protein, small 3
# AltName	AP3S1_HUMAN	Sigma-3A-adaptin
# AltName	AP3S1_HUMAN	Sigma-adaptin 3a
# BioGrid	107590	50
# ChiTaRS	AP3S1	human
# Ensembl	ENST00000316788	ENSP00000325369; ENSG00000177879
# ExpressionAtlas	Q92572	baseline and differential
# FUNCTION	AP3S1_HUMAN	Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. 
# GO_component	GO:0005794	Golgi apparatus; IEA:UniProtKB-SubCell.
# GO_component	GO:0030119	AP-type membrane coat adaptor complex; TAS:ProtInc.
# GO_component	GO:0030123	AP-3 adaptor complex; IDA:FlyBase.
# GO_component	GO:0030133	transport vesicle; TAS:ProtInc.
# GO_component	GO:0030659	cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_component	GO:1904115	axon cytoplasm; IEA:GOC.
# GO_function	GO:0005215	transporter activity; NAS:ProtInc.
# GO_function	GO:0008565	protein transporter activity; IEA:InterPro.
# GO_process	GO:0006886	intracellular protein transport; IEA:InterPro.
# GO_process	GO:0008089	anterograde axonal transport; ISS:UniProtKB.
# GO_process	GO:0008286	insulin receptor signaling pathway; TAS:ProtInc.
# GO_process	GO:0048490	anterograde synaptic vesicle transport; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0030705	cytoskeleton-dependent intracellular transport
# Genevisible	Q92572	HS
# HGNC	HGNC:2013	AP3S1
# IntAct	Q92572	11
# InterPro	IPR000804	Clathrin_sm-chain_CS
# InterPro	IPR011012	Longin-like_dom
# InterPro	IPR016635	AP_complex_ssu
# InterPro	IPR022775	AP_mu_sigma_su
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Pathway	ko04142	Lysosome
# MIM	601507	gene
# Organism	AP3S1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11753	PTHR11753
# PROSITE	PS00989	CLAT_ADAPTOR_S
# Pfam	PF01217	Clat_adaptor_s
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-432722	Golgi Associated Vesicle Biogenesis
# RecName	AP3S1_HUMAN	AP-3 complex subunit sigma-1
# RefSeq	NP_001002924	NM_001002924.2
# RefSeq	NP_001275	NM_001284.3
# RefSeq	NP_001305019	NM_001318090.1
# RefSeq	NP_001305020	NM_001318091.1
# RefSeq	NP_001305022	NM_001318093.1
# RefSeq	NP_001305023	NM_001318094.1
# SIMILARITY	Belongs to the adaptor complexes small subunit family. {ECO	0000305}.
# SUBCELLULAR LOCATION	AP3S1_HUMAN	Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. 
# SUBUNIT	Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta- type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2). Interacts with AGAP1. AP-3 associates with the BLOC-1 complex (By similarity). {ECO	0000250}. 
# SUPFAM	SSF64356	SSF64356
# TISSUE SPECIFICITY	AP3S1_HUMAN	Present in all adult tissues examined. {ECO 0000269|PubMed 8697810, ECO 0000269|PubMed 9118953, ECO 0000269|PubMed 9151686}. 
# UCSC	uc003krl	human
# eggNOG	COG5030	LUCA
# eggNOG	KOG0936	Eukaryota
BLAST	swissprot:AP3S1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AP3S1_HUMAN
BioCyc	ZFISH:ENSG00000177879-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000177879-MONOMER
COXPRESdb	1176	http://coxpresdb.jp/data/gene/1176.shtml
CleanEx	HS_AP3S1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AP3S1
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1083/jcb.137.4.835	http://dx.doi.org/10.1083/jcb.137.4.835
DOI	10.1093/emboj/16.5.917	http://dx.doi.org/10.1093/emboj/16.5.917
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	BC000804	http://www.ebi.ac.uk/ena/data/view/BC000804
EMBL	BT009833	http://www.ebi.ac.uk/ena/data/view/BT009833
EMBL	CR450341	http://www.ebi.ac.uk/ena/data/view/CR450341
EMBL	D63643	http://www.ebi.ac.uk/ena/data/view/D63643
EMBL	U91932	http://www.ebi.ac.uk/ena/data/view/U91932
EMBL	X99458	http://www.ebi.ac.uk/ena/data/view/X99458
Ensembl	ENST00000316788	http://www.ensembl.org/id/ENST00000316788
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0030119	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030119
GO_component	GO:0030123	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030123
GO_component	GO:0030133	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030133
GO_component	GO:0030659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030659
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_component	GO:1904115	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1904115
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0006886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006886
GO_process	GO:0008089	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008089
GO_process	GO:0008286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008286
GO_process	GO:0048490	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048490
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0030705	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030705
GeneCards	AP3S1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=AP3S1
GeneID	1176	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1176
GeneTree	ENSGT00550000074761	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074761
HGNC	HGNC:2013	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2013
HOVERGEN	HBG050517	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050517&db=HOVERGEN
HPA	HPA049270	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA049270
InParanoid	Q92572	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q92572
IntAct	Q92572	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q92572*
InterPro	IPR000804	http://www.ebi.ac.uk/interpro/entry/IPR000804
InterPro	IPR011012	http://www.ebi.ac.uk/interpro/entry/IPR011012
InterPro	IPR016635	http://www.ebi.ac.uk/interpro/entry/IPR016635
InterPro	IPR022775	http://www.ebi.ac.uk/interpro/entry/IPR022775
Jabion	1176	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1176
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Gene	hsa:1176	http://www.genome.jp/dbget-bin/www_bget?hsa:1176
KEGG_Orthology	KO:K12399	http://www.genome.jp/dbget-bin/www_bget?KO:K12399
KEGG_Pathway	ko04142	http://www.genome.jp/kegg-bin/show_pathway?ko04142
MIM	601507	http://www.ncbi.nlm.nih.gov/omim/601507
OMA	HYSEDTE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HYSEDTE
OrthoDB	EOG091G0QZV	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0QZV
PANTHER	PTHR11753	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11753
PROSITE	PS00989	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00989
PSORT	swissprot:AP3S1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AP3S1_HUMAN
PSORT-B	swissprot:AP3S1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AP3S1_HUMAN
PSORT2	swissprot:AP3S1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AP3S1_HUMAN
Pfam	PF01217	http://pfam.xfam.org/family/PF01217
PharmGKB	PA24862	http://www.pharmgkb.org/do/serve?objId=PA24862&objCls=Gene
Phobius	swissprot:AP3S1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AP3S1_HUMAN
PhylomeDB	Q92572	http://phylomedb.org/?seqid=Q92572
ProteinModelPortal	Q92572	http://www.proteinmodelportal.org/query/uniprot/Q92572
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	8697810	http://www.ncbi.nlm.nih.gov/pubmed/8697810
PubMed	9118953	http://www.ncbi.nlm.nih.gov/pubmed/9118953
PubMed	9151686	http://www.ncbi.nlm.nih.gov/pubmed/9151686
Reactome	R-HSA-432722	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432722
RefSeq	NP_001002924	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001002924
RefSeq	NP_001275	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001275
RefSeq	NP_001305019	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001305019
RefSeq	NP_001305020	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001305020
RefSeq	NP_001305022	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001305022
RefSeq	NP_001305023	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001305023
SMR	Q92572	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q92572
STRING	9606.ENSP00000325369	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000325369&targetmode=cogs
SUPFAM	SSF64356	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF64356
UCSC	uc003krl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003krl&org=rat
UniGene	Hs.406191	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.406191
UniProtKB	AP3S1_HUMAN	http://www.uniprot.org/uniprot/AP3S1_HUMAN
UniProtKB-AC	Q92572	http://www.uniprot.org/uniprot/Q92572
charge	swissprot:AP3S1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AP3S1_HUMAN
eggNOG	COG5030	http://eggnogapi.embl.de/nog_data/html/tree/COG5030
eggNOG	KOG0936	http://eggnogapi.embl.de/nog_data/html/tree/KOG0936
epestfind	swissprot:AP3S1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AP3S1_HUMAN
garnier	swissprot:AP3S1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AP3S1_HUMAN
helixturnhelix	swissprot:AP3S1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AP3S1_HUMAN
hmoment	swissprot:AP3S1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AP3S1_HUMAN
iep	swissprot:AP3S1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AP3S1_HUMAN
inforesidue	swissprot:AP3S1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AP3S1_HUMAN
neXtProt	NX_Q92572	http://www.nextprot.org/db/entry/NX_Q92572
octanol	swissprot:AP3S1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AP3S1_HUMAN
pepcoil	swissprot:AP3S1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AP3S1_HUMAN
pepdigest	swissprot:AP3S1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AP3S1_HUMAN
pepinfo	swissprot:AP3S1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AP3S1_HUMAN
pepnet	swissprot:AP3S1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AP3S1_HUMAN
pepstats	swissprot:AP3S1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AP3S1_HUMAN
pepwheel	swissprot:AP3S1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AP3S1_HUMAN
pepwindow	swissprot:AP3S1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AP3S1_HUMAN
sigcleave	swissprot:AP3S1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AP3S1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CTL3_HUMAN	Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q8N4M1-1; Sequence=Displayed; Name=2; IsoId=Q8N4M1-2; Sequence=VSP_036151; Name=3; IsoId=Q8N4M1-3; Sequence=VSP_036152; Name=4; IsoId=Q8N4M1-4; Sequence=VSP_036152, VSP_044713; Note=No experimental confirmation available.; Name=5; IsoId=Q8N4M1-5; Sequence=VSP_036151, VSP_044713, VSP_045974; Note=No experimental confirmation available.; Name=6; IsoId=Q8N4M1-6; Sequence=VSP_044713, VSP_045974; Note=No experimental confirmation available.; 
# AltName	CTL3_HUMAN	Solute carrier family 44 member 3
# CCDS	CCDS44176	-. [Q8N4M1-1]
# CCDS	CCDS58011	-. [Q8N4M1-6]
# CCDS	CCDS58012	-. [Q8N4M1-4]
# CCDS	CCDS58013	-. [Q8N4M1-3]
# CCDS	CCDS751	-. [Q8N4M1-2]
# ChiTaRS	SLC44A3	human
# DrugBank	DB00122	Choline
# Ensembl	ENST00000271227	ENSP00000271227; ENSG00000143036. [Q8N4M1-1]
# Ensembl	ENST00000446120	ENSP00000389143; ENSG00000143036. [Q8N4M1-3]
# Ensembl	ENST00000467909	ENSP00000432789; ENSG00000143036. [Q8N4M1-2]
# Ensembl	ENST00000527077	ENSP00000433641; ENSG00000143036. [Q8N4M1-4]
# Ensembl	ENST00000529450	ENSP00000431836; ENSG00000143036. [Q8N4M1-6]
# ExpressionAtlas	Q8N4M1	baseline and differential
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015220	choline transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0006656	phosphatidylcholine biosynthetic process; TAS:Reactome.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q8N4M1	HS
# HGNC	HGNC:28689	SLC44A3
# INTERACTION	CTL3_HUMAN	Q13643 FHL3; NbExp=3; IntAct=EBI-10265585, EBI-741101; 
# IntAct	Q8N4M1	2
# InterPro	IPR007603	Choline_transptr-like
# KEGG_Brite	ko02001	Solute carrier family
# Organism	CTL3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12385	PTHR12385
# Pfam	PF04515	Choline_transpo
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-1483191	Synthesis of PC
# Reactome	R-HSA-425366	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
# RecName	CTL3_HUMAN	Choline transporter-like protein 3
# RefSeq	NP_001107578	NM_001114106.2. [Q8N4M1-1]
# RefSeq	NP_001245269	NM_001258340.1
# RefSeq	NP_001245270	NM_001258341.1. [Q8N4M1-6]
# RefSeq	NP_001245271	NM_001258342.1. [Q8N4M1-3]
# RefSeq	NP_001245272	NM_001258343.1. [Q8N4M1-4]
# RefSeq	NP_001288008	NM_001301079.1
# RefSeq	NP_689582	NM_152369.4. [Q8N4M1-2]
# RefSeq	XP_005270498	XM_005270441.2. [Q8N4M1-2]
# SEQUENCE CAUTION	Sequence=AAH33858.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ89022.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the CTL (choline transporter-like) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	CTL3_HUMAN	Membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# TCDB	2.A.92.1	the choline transporter-like (ctl) family
# UCSC	uc001dqv	human. [Q8N4M1-1]
# eggNOG	ENOG410XS0P	LUCA
# eggNOG	KOG1362	Eukaryota
BLAST	swissprot:CTL3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CTL3_HUMAN
BioCyc	ZFISH:ENSG00000143036-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000143036-MONOMER
COXPRESdb	126969	http://coxpresdb.jp/data/gene/126969.shtml
CleanEx	HS_SLC44A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC44A3
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/nature09639	http://dx.doi.org/10.1038/nature09639
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.030339697	http://dx.doi.org/10.1073/pnas.030339697
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00122	http://www.drugbank.ca/drugs/DB00122
EMBL	AC093429	http://www.ebi.ac.uk/ena/data/view/AC093429
EMBL	AK301288	http://www.ebi.ac.uk/ena/data/view/AK301288
EMBL	AK303906	http://www.ebi.ac.uk/ena/data/view/AK303906
EMBL	AK316123	http://www.ebi.ac.uk/ena/data/view/AK316123
EMBL	AL359554	http://www.ebi.ac.uk/ena/data/view/AL359554
EMBL	AY358659	http://www.ebi.ac.uk/ena/data/view/AY358659
EMBL	BC033858	http://www.ebi.ac.uk/ena/data/view/BC033858
EMBL	BC053877	http://www.ebi.ac.uk/ena/data/view/BC053877
Ensembl	ENST00000271227	http://www.ensembl.org/id/ENST00000271227
Ensembl	ENST00000446120	http://www.ensembl.org/id/ENST00000446120
Ensembl	ENST00000467909	http://www.ensembl.org/id/ENST00000467909
Ensembl	ENST00000527077	http://www.ensembl.org/id/ENST00000527077
Ensembl	ENST00000529450	http://www.ensembl.org/id/ENST00000529450
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015220
GO_process	GO:0006656	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006656
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC44A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC44A3
GeneID	126969	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=126969
GeneTree	ENSGT00550000074521	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074521
H-InvDB	HIX0023639	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0023639
HGNC	HGNC:28689	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:28689
HOGENOM	HOG000231655	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231655&db=HOGENOM6
HOVERGEN	HBG080361	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG080361&db=HOVERGEN
HPA	HPA047433	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA047433
InParanoid	Q8N4M1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8N4M1
IntAct	Q8N4M1	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8N4M1*
InterPro	IPR007603	http://www.ebi.ac.uk/interpro/entry/IPR007603
Jabion	126969	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=126969
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:126969	http://www.genome.jp/dbget-bin/www_bget?hsa:126969
KEGG_Orthology	KO:K15282	http://www.genome.jp/dbget-bin/www_bget?KO:K15282
OMA	KCTDTAW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KCTDTAW
OrthoDB	EOG091G0CMQ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0CMQ
PANTHER	PTHR12385	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12385
PSORT	swissprot:CTL3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CTL3_HUMAN
PSORT-B	swissprot:CTL3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CTL3_HUMAN
PSORT2	swissprot:CTL3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CTL3_HUMAN
Pfam	PF04515	http://pfam.xfam.org/family/PF04515
PharmGKB	PA142670900	http://www.pharmgkb.org/do/serve?objId=PA142670900&objCls=Gene
Phobius	swissprot:CTL3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CTL3_HUMAN
PhylomeDB	Q8N4M1	http://phylomedb.org/?seqid=Q8N4M1
ProteinModelPortal	Q8N4M1	http://www.proteinmodelportal.org/query/uniprot/Q8N4M1
PubMed	10677542	http://www.ncbi.nlm.nih.gov/pubmed/10677542
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	21248752	http://www.ncbi.nlm.nih.gov/pubmed/21248752
Reactome	R-HSA-1483191	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1483191
Reactome	R-HSA-425366	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425366
RefSeq	NP_001107578	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001107578
RefSeq	NP_001245269	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001245269
RefSeq	NP_001245270	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001245270
RefSeq	NP_001245271	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001245271
RefSeq	NP_001245272	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001245272
RefSeq	NP_001288008	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001288008
RefSeq	NP_689582	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_689582
RefSeq	XP_005270498	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005270498
STRING	9606.ENSP00000271227	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000271227&targetmode=cogs
TCDB	2.A.92.1	http://www.tcdb.org/search/result.php?tc=2.A.92.1
UCSC	uc001dqv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001dqv&org=rat
UniGene	Hs.483423	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.483423
UniProtKB	CTL3_HUMAN	http://www.uniprot.org/uniprot/CTL3_HUMAN
UniProtKB-AC	Q8N4M1	http://www.uniprot.org/uniprot/Q8N4M1
charge	swissprot:CTL3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CTL3_HUMAN
eggNOG	ENOG410XS0P	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS0P
eggNOG	KOG1362	http://eggnogapi.embl.de/nog_data/html/tree/KOG1362
epestfind	swissprot:CTL3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CTL3_HUMAN
garnier	swissprot:CTL3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CTL3_HUMAN
helixturnhelix	swissprot:CTL3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CTL3_HUMAN
hmoment	swissprot:CTL3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CTL3_HUMAN
iep	swissprot:CTL3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CTL3_HUMAN
inforesidue	swissprot:CTL3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CTL3_HUMAN
neXtProt	NX_Q8N4M1	http://www.nextprot.org/db/entry/NX_Q8N4M1
octanol	swissprot:CTL3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CTL3_HUMAN
pepcoil	swissprot:CTL3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CTL3_HUMAN
pepdigest	swissprot:CTL3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CTL3_HUMAN
pepinfo	swissprot:CTL3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CTL3_HUMAN
pepnet	swissprot:CTL3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CTL3_HUMAN
pepstats	swissprot:CTL3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CTL3_HUMAN
pepwheel	swissprot:CTL3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CTL3_HUMAN
pepwindow	swissprot:CTL3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CTL3_HUMAN
sigcleave	swissprot:CTL3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CTL3_HUMAN
## Database	ID	URL or Descriptions
# AltName	PLM_HUMAN	FXYD domain-containing ion transport regulator 1
# BioGrid	111363	14
# Ensembl	ENST00000351325	ENSP00000343314; ENSG00000266964
# Ensembl	ENST00000455515	ENSP00000393611; ENSG00000266964
# Ensembl	ENST00000588081	ENSP00000467727; ENSG00000266964
# Ensembl	ENST00000588607	ENSP00000468535; ENSG00000266964
# Ensembl	ENST00000588715	ENSP00000465289; ENSG00000266964
# Ensembl	ENST00000589209	ENSP00000466398; ENSG00000266964
# Ensembl	ENST00000612146	ENSP00000481244; ENSG00000266964
# ExpressionAtlas	O00168	baseline and differential
# FUNCTION	PLM_HUMAN	May have a functional role in muscle contraction. Induces a hyperpolarization-activated chloride current when exogenously expressed. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0042383	sarcolemma; ISS:BHF-UCL.
# GO_component	PLM_HUMAN	GO 0005890 sodium potassium-exchanging ATPase complex; ISS BHF-UCL.
# GO_function	GO:0005254	chloride channel activity; TAS:ProtInc.
# GO_function	GO:0017080	sodium channel regulator activity; ISS:BHF-UCL.
# GO_function	GO:0044325	ion channel binding; ISS:BHF-UCL.
# GO_process	GO:0006821	chloride transport; TAS:ProtInc.
# GO_process	GO:0006936	muscle contraction; TAS:ProtInc.
# GO_process	GO:0008016	regulation of heart contraction; TAS:BHF-UCL.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0086036	regulation of cardiac muscle cell membrane potential; ISS:BHF-UCL.
# GO_process	GO:1903278	positive regulation of sodium ion export from cell; ISS:BHF-UCL.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GO_process	GO:2000649	regulation of sodium ion transmembrane transporter activity; ISS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	O00168	HS
# HGNC	HGNC:4025	FXYD1
# InterPro	IPR000272	Ion-transport_regulator_FXYD
# KEGG_Brite	ko02000	Transporters
# MIM	602359	gene
# Organism	PLM_HUMAN	Homo sapiens (Human)
# PDB	2J1I	Model; -; A/B/C/D=32-59
# PDB	2JO1	NMR; -; A=21-92
# PROSITE	PS01310	FXYD
# PTM	PLM_HUMAN	Major plasma membrane substrate for cAMP-dependent protein kinase (PK-A) and protein kinase C (PK-C) in several different tissues (By similarity). Phosphorylated in response to insulin and adrenergic stimulation. May be phosphorylated by DMPK. {ECO 0000250}. 
# PTM	PLM_HUMAN	Palmitoylation increases half-life and stability, it is enhanced upon phosphorylation at Ser-88 by PKA. {ECO 0000269|PubMed 10811636, ECO 0000269|PubMed 21868384}. 
# Pfam	PF02038	ATP1G1_PLM_MAT8
# ProDom	PD005989	PD005989
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-5578775	Ion homeostasis
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	PLM_HUMAN	Phospholemman
# RefSeq	NP_001265646	NM_001278717.1
# RefSeq	NP_001265647	NM_001278718.1
# RefSeq	NP_005022	NM_005031.4
# RefSeq	NP_068702	NM_021902.3
# RefSeq	XP_016882363	XM_017026874.1
# SIMILARITY	Belongs to the FXYD family. {ECO	0000305}.
# SUBCELLULAR LOCATION	PLM_HUMAN	Membrane; Single-pass type I membrane protein. 
# TISSUE SPECIFICITY	PLM_HUMAN	Highest expression in skeletal muscle and heart. Moderate levels in brain, placenta, lung, liver, pancreas, uterus, bladder, prostate, small intestine and colon with mucosal lining. Very low levels in kidney, colon and small intestine without mucosa, prostate without endothelial lining, spleen, and testis. 
# UCSC	uc002nyc	human
# eggNOG	ENOG410J08K	Eukaryota
# eggNOG	ENOG410YYN6	LUCA
BLAST	swissprot:PLM_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:PLM_HUMAN
BioCyc	ZFISH:G66-31696-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31696-MONOMER
COXPRESdb	5348	http://coxpresdb.jp/data/gene/5348.shtml
CleanEx	HS_FXYD1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_FXYD1
DOI	10.1006/geno.1997.4665	http://dx.doi.org/10.1006/geno.1997.4665
DOI	10.1006/geno.2000.6274	http://dx.doi.org/10.1006/geno.2000.6274
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M000899200	http://dx.doi.org/10.1074/jbc.M000899200
DOI	10.1074/jbc.M111.282145	http://dx.doi.org/10.1074/jbc.M111.282145
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AK289811	http://www.ebi.ac.uk/ena/data/view/AK289811
EMBL	BC032800	http://www.ebi.ac.uk/ena/data/view/BC032800
EMBL	U72245	http://www.ebi.ac.uk/ena/data/view/U72245
Ensembl	ENST00000351325	http://www.ensembl.org/id/ENST00000351325
Ensembl	ENST00000455515	http://www.ensembl.org/id/ENST00000455515
Ensembl	ENST00000588081	http://www.ensembl.org/id/ENST00000588081
Ensembl	ENST00000588607	http://www.ensembl.org/id/ENST00000588607
Ensembl	ENST00000588715	http://www.ensembl.org/id/ENST00000588715
Ensembl	ENST00000589209	http://www.ensembl.org/id/ENST00000589209
Ensembl	ENST00000612146	http://www.ensembl.org/id/ENST00000612146
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005890
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0042383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042383
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0017080	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017080
GO_function	GO:0044325	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044325
GO_process	GO:0006821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006821
GO_process	GO:0006936	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006936
GO_process	GO:0008016	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008016
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0086036	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086036
GO_process	GO:1903278	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903278
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GO_process	GO:2000649	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000649
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	FXYD1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=FXYD1
GeneID	5348	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5348
GeneTree	ENSGT00530000063932	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063932
HGNC	HGNC:4025	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4025
HOGENOM	HOG000234467	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234467&db=HOGENOM6
HOVERGEN	HBG008212	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG008212&db=HOVERGEN
HPA	HPA026873	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA026873
InParanoid	O00168	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O00168
InterPro	IPR000272	http://www.ebi.ac.uk/interpro/entry/IPR000272
Jabion	5348	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=5348
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:5348	http://www.genome.jp/dbget-bin/www_bget?hsa:5348
KEGG_Orthology	KO:K13360	http://www.genome.jp/dbget-bin/www_bget?KO:K13360
MIM	602359	http://www.ncbi.nlm.nih.gov/omim/602359
PDB	2J1I	http://www.ebi.ac.uk/pdbe-srv/view/entry/2J1I
PDB	2JO1	http://www.ebi.ac.uk/pdbe-srv/view/entry/2JO1
PDBsum	2J1I	http://www.ebi.ac.uk/pdbsum/2J1I
PDBsum	2JO1	http://www.ebi.ac.uk/pdbsum/2JO1
PROSITE	PS01310	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01310
PSORT	swissprot:PLM_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:PLM_HUMAN
PSORT-B	swissprot:PLM_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:PLM_HUMAN
PSORT2	swissprot:PLM_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:PLM_HUMAN
Pfam	PF02038	http://pfam.xfam.org/family/PF02038
PharmGKB	PA28441	http://www.pharmgkb.org/do/serve?objId=PA28441&objCls=Gene
Phobius	swissprot:PLM_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:PLM_HUMAN
PhylomeDB	O00168	http://phylomedb.org/?seqid=O00168
ProteinModelPortal	O00168	http://www.proteinmodelportal.org/query/uniprot/O00168
PubMed	10811636	http://www.ncbi.nlm.nih.gov/pubmed/10811636
PubMed	10950925	http://www.ncbi.nlm.nih.gov/pubmed/10950925
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21868384	http://www.ncbi.nlm.nih.gov/pubmed/21868384
PubMed	9169143	http://www.ncbi.nlm.nih.gov/pubmed/9169143
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_001265646	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001265646
RefSeq	NP_001265647	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001265647
RefSeq	NP_005022	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005022
RefSeq	NP_068702	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_068702
RefSeq	XP_016882363	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016882363
SMR	O00168	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O00168
STRING	9606.ENSP00000343314	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000343314&targetmode=cogs
UCSC	uc002nyc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002nyc&org=rat
UniGene	Hs.442498	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.442498
UniProtKB	PLM_HUMAN	http://www.uniprot.org/uniprot/PLM_HUMAN
UniProtKB-AC	O00168	http://www.uniprot.org/uniprot/O00168
charge	swissprot:PLM_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:PLM_HUMAN
eggNOG	ENOG410J08K	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410J08K
eggNOG	ENOG410YYN6	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YYN6
epestfind	swissprot:PLM_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:PLM_HUMAN
garnier	swissprot:PLM_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:PLM_HUMAN
helixturnhelix	swissprot:PLM_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:PLM_HUMAN
hmoment	swissprot:PLM_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:PLM_HUMAN
iep	swissprot:PLM_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:PLM_HUMAN
inforesidue	swissprot:PLM_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:PLM_HUMAN
neXtProt	NX_O00168	http://www.nextprot.org/db/entry/NX_O00168
octanol	swissprot:PLM_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:PLM_HUMAN
pepcoil	swissprot:PLM_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:PLM_HUMAN
pepdigest	swissprot:PLM_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:PLM_HUMAN
pepinfo	swissprot:PLM_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:PLM_HUMAN
pepnet	swissprot:PLM_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:PLM_HUMAN
pepstats	swissprot:PLM_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:PLM_HUMAN
pepwheel	swissprot:PLM_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:PLM_HUMAN
pepwindow	swissprot:PLM_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:PLM_HUMAN
sigcleave	swissprot:PLM_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:PLM_HUMAN
## Database	ID	URL or Descriptions
# AltName	COX41_HUMAN	Cytochrome c oxidase polypeptide IV
# AltName	COX41_HUMAN	Cytochrome c oxidase subunit IV isoform 1
# BioGrid	107720	52
# CDD	cd00922	Cyt_c_Oxidase_IV
# ChiTaRS	COX4I1	human
# DrugBank	DB02659	Cholic Acid
# Ensembl	ENST00000253452	ENSP00000253452; ENSG00000131143
# Ensembl	ENST00000561569	ENSP00000457015; ENSG00000131143
# Ensembl	ENST00000562336	ENSP00000457513; ENSG00000131143
# ExpressionAtlas	P13073	baseline and differential
# FUNCTION	COX41_HUMAN	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. 
# GO_component	GO:0005634	nucleus; IDA:HPA.
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0005751	mitochondrial respiratory chain complex IV; IBA:GO_Central.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0004129	cytochrome-c oxidase activity; TAS:ProtInc.
# GO_process	GO:0006091	generation of precursor metabolites and energy; TAS:ProtInc.
# GO_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen; IBA:GO_Central.
# GO_process	GO:0007584	response to nutrient; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.10.442.10	-; 1.
# Genevisible	P13073	HS
# HGNC	HGNC:2265	COX4I1
# INTERACTION	COX41_HUMAN	P00395 MT-CO1; NbExp=2; IntAct=EBI-1056574, EBI-2117234; O00560 SDCBP; NbExp=3; IntAct=EBI-1056574, EBI-727004; 
# IntAct	P13073	17
# InterPro	IPR004203	Cyt_c_oxidase_su4_fam
# InterPro	IPR013288	Cyt_c_oxidase_su4
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	123864	gene
# Organism	COX41_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10707	PTHR10707
# PIR	S47012	OLHU4
# PRINTS	PR01873	CYTCOXIDASE4
# Pfam	PF02936	COX4
# Proteomes	UP000005640	Chromosome 16
# Reactome	R-HSA-5628897	TP53 Regulates Metabolic Genes
# Reactome	R-HSA-611105	Respiratory electron transport
# RecName	COX41_HUMAN	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
# RefSeq	NP_001305715	NM_001318786.1
# RefSeq	NP_001305717	NM_001318788.1
# RefSeq	NP_001305723	NM_001318794.1
# RefSeq	NP_001305726	NM_001318797.1
# RefSeq	NP_001305731	NM_001318802.1
# RefSeq	NP_001852	NM_001861.4
# SIMILARITY	Belongs to the cytochrome c oxidase IV family. {ECO	0000305}.
# SUBCELLULAR LOCATION	COX41_HUMAN	Mitochondrion inner membrane. 
# SUPFAM	SSF81406	SSF81406
# TCDB	3.D.4.11	the proton-translocating cytochrome oxidase (cox) superfamily
# TISSUE SPECIFICITY	COX41_HUMAN	Ubiquitous. 
# UCSC	uc002fje	human
# eggNOG	ENOG4111T97	LUCA
# eggNOG	KOG4075	Eukaryota
BLAST	swissprot:COX41_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:COX41_HUMAN
BioCyc	ZFISH:HS05494-MONOMER	http://biocyc.org/getid?id=ZFISH:HS05494-MONOMER
COXPRESdb	1327	http://coxpresdb.jp/data/gene/1327.shtml
CleanEx	HS_COX4I1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_COX4I1
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1007/s003359901031	http://dx.doi.org/10.1007/s003359901031
DOI	10.1016/0167-4838(92)90395-T	http://dx.doi.org/10.1016/0167-4838(92)90395-T
DOI	10.1016/0378-1119(87)90281-2	http://dx.doi.org/10.1016/0378-1119(87)90281-2
DOI	10.1016/0378-1119(90)90281-U	http://dx.doi.org/10.1016/0378-1119(90)90281-U
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DrugBank	DB02659	http://www.drugbank.ca/drugs/DB02659
EMBL	AF005889	http://www.ebi.ac.uk/ena/data/view/AF005889
EMBL	AF017115	http://www.ebi.ac.uk/ena/data/view/AF017115
EMBL	AH005828	http://www.ebi.ac.uk/ena/data/view/AH005828
EMBL	AK311847	http://www.ebi.ac.uk/ena/data/view/AK311847
EMBL	BC008704	http://www.ebi.ac.uk/ena/data/view/BC008704
EMBL	BC021236	http://www.ebi.ac.uk/ena/data/view/BC021236
EMBL	BC062437	http://www.ebi.ac.uk/ena/data/view/BC062437
EMBL	BT019825	http://www.ebi.ac.uk/ena/data/view/BT019825
EMBL	CH471114	http://www.ebi.ac.uk/ena/data/view/CH471114
EMBL	CH471114	http://www.ebi.ac.uk/ena/data/view/CH471114
EMBL	M21575	http://www.ebi.ac.uk/ena/data/view/M21575
EMBL	M34600	http://www.ebi.ac.uk/ena/data/view/M34600
EMBL	U90915	http://www.ebi.ac.uk/ena/data/view/U90915
EMBL	X54802	http://www.ebi.ac.uk/ena/data/view/X54802
Ensembl	ENST00000253452	http://www.ensembl.org/id/ENST00000253452
Ensembl	ENST00000561569	http://www.ensembl.org/id/ENST00000561569
Ensembl	ENST00000562336	http://www.ensembl.org/id/ENST00000562336
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005751	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005751
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0004129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004129
GO_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GO_process	GO:0006123	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006123
GO_process	GO:0007584	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007584
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.10.442.10	http://www.cathdb.info/version/latest/superfamily/1.10.442.10
GeneCards	COX4I1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=COX4I1
GeneID	1327	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1327
GeneTree	ENSGT00390000002407	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002407
HGNC	HGNC:2265	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2265
HOGENOM	HOG000231486	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231486&db=HOGENOM6
HOVERGEN	HBG051087	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051087&db=HOVERGEN
HPA	CAB004080	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB004080
HPA	HPA002485	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA002485
InParanoid	P13073	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P13073
IntAct	P13073	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P13073*
InterPro	IPR004203	http://www.ebi.ac.uk/interpro/entry/IPR004203
InterPro	IPR013288	http://www.ebi.ac.uk/interpro/entry/IPR013288
Jabion	1327	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1327
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Gene	hsa:1327	http://www.genome.jp/dbget-bin/www_bget?hsa:1327
KEGG_Orthology	KO:K02263	http://www.genome.jp/dbget-bin/www_bget?KO:K02263
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	123864	http://www.ncbi.nlm.nih.gov/omim/123864
MINT	MINT-3007868	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3007868
OMA	EKHYVYG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EKHYVYG
OrthoDB	EOG091G0XDH	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0XDH
PANTHER	PTHR10707	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10707
PRINTS	PR01873	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01873
PSORT	swissprot:COX41_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:COX41_HUMAN
PSORT-B	swissprot:COX41_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:COX41_HUMAN
PSORT2	swissprot:COX41_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:COX41_HUMAN
Pfam	PF02936	http://pfam.xfam.org/family/PF02936
PharmGKB	PA26781	http://www.pharmgkb.org/do/serve?objId=PA26781&objCls=Gene
Phobius	swissprot:COX41_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:COX41_HUMAN
PhylomeDB	P13073	http://phylomedb.org/?seqid=P13073
ProteinModelPortal	P13073	http://www.proteinmodelportal.org/query/uniprot/P13073
PubMed	10337626	http://www.ncbi.nlm.nih.gov/pubmed/10337626
PubMed	1311608	http://www.ncbi.nlm.nih.gov/pubmed/1311608
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	2157630	http://www.ncbi.nlm.nih.gov/pubmed/2157630
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	2444497	http://www.ncbi.nlm.nih.gov/pubmed/2444497
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-5628897	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5628897
Reactome	R-HSA-611105	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-611105
RefSeq	NP_001305715	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001305715
RefSeq	NP_001305717	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001305717
RefSeq	NP_001305723	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001305723
RefSeq	NP_001305726	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001305726
RefSeq	NP_001305731	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001305731
RefSeq	NP_001852	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001852
SMR	P13073	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P13073
STRING	9606.ENSP00000253452	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000253452&targetmode=cogs
SUPFAM	SSF81406	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81406
TCDB	3.D.4.11	http://www.tcdb.org/search/result.php?tc=3.D.4.11
UCSC	uc002fje	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002fje&org=rat
UniGene	Hs.433419	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.433419
UniProtKB	COX41_HUMAN	http://www.uniprot.org/uniprot/COX41_HUMAN
UniProtKB-AC	P13073	http://www.uniprot.org/uniprot/P13073
charge	swissprot:COX41_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:COX41_HUMAN
eggNOG	ENOG4111T97	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111T97
eggNOG	KOG4075	http://eggnogapi.embl.de/nog_data/html/tree/KOG4075
epestfind	swissprot:COX41_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:COX41_HUMAN
garnier	swissprot:COX41_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:COX41_HUMAN
helixturnhelix	swissprot:COX41_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:COX41_HUMAN
hmoment	swissprot:COX41_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:COX41_HUMAN
iep	swissprot:COX41_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:COX41_HUMAN
inforesidue	swissprot:COX41_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:COX41_HUMAN
neXtProt	NX_P13073	http://www.nextprot.org/db/entry/NX_P13073
octanol	swissprot:COX41_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:COX41_HUMAN
pepcoil	swissprot:COX41_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:COX41_HUMAN
pepdigest	swissprot:COX41_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:COX41_HUMAN
pepinfo	swissprot:COX41_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:COX41_HUMAN
pepnet	swissprot:COX41_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:COX41_HUMAN
pepstats	swissprot:COX41_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:COX41_HUMAN
pepwheel	swissprot:COX41_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:COX41_HUMAN
pepwindow	swissprot:COX41_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:COX41_HUMAN
sigcleave	swissprot:COX41_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:COX41_HUMAN
## Database	ID	URL or Descriptions
# AltName	XPO1_HUMAN	Chromosome region maintenance 1 protein homolog
# BioGrid	113348	1229
# ChiTaRS	XPO1	human
# Ensembl	ENST00000401558	ENSP00000384863; ENSG00000082898
# Ensembl	ENST00000404992	ENSP00000385942; ENSG00000082898
# Ensembl	ENST00000406957	ENSP00000385559; ENSG00000082898
# ExpressionAtlas	O14980	baseline and differential
# FUNCTION	XPO1_HUMAN	Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization. {ECO 0000269|PubMed 14612415, ECO 0000269|PubMed 15574332, ECO 0000269|PubMed 20921223, ECO 0000269|PubMed 9311922, ECO 0000269|PubMed 9323133, ECO 0000269|PubMed 9837918}. 
# GO_component	GO:0000776	kinetochore; IDA:UniProtKB.
# GO_component	GO:0005634	nucleus; IDA:HPA.
# GO_component	GO:0005635	nuclear envelope; TAS:ProtInc.
# GO_component	GO:0005642	annulate lamellae; IDA:UniProtKB.
# GO_component	GO:0005654	nucleoplasm; TAS:Reactome.
# GO_component	GO:0005730	nucleolus; IEA:UniProtKB-SubCell.
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0015030	Cajal body; IEA:UniProtKB-SubCell.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0030529	intracellular ribonucleoprotein complex; IDA:MGI.
# GO_component	GO:0031965	nuclear membrane; IDA:HPA.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_function	GO:0003723	RNA binding; IEA:UniProtKB-KW.
# GO_function	GO:0005049	nuclear export signal receptor activity; IBA:GO_Central.
# GO_function	GO:0005215	transporter activity; TAS:Reactome.
# GO_function	GO:0005487	nucleocytoplasmic transporter activity; IMP:ParkinsonsUK-UCL.
# GO_process	GO:0000055	ribosomal large subunit export from nucleus; IMP:ParkinsonsUK-UCL.
# GO_process	GO:0000056	ribosomal small subunit export from nucleus; IMP:ParkinsonsUK-UCL.
# GO_process	GO:0000122	negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
# GO_process	GO:0006611	protein export from nucleus; IDA:GO_Central.
# GO_process	GO:0007062	sister chromatid cohesion; TAS:Reactome.
# GO_process	GO:0010824	regulation of centrosome duplication; IEA:Ensembl.
# GO_process	GO:0016032	viral process; TAS:Reactome.
# GO_process	GO:0034504	protein localization to nucleus; IEA:Ensembl.
# GO_process	GO:0042176	regulation of protein catabolic process; IEA:Ensembl.
# GO_process	GO:0042493	response to drug; IEA:Ensembl.
# GO_process	GO:0043488	regulation of mRNA stability; TAS:Reactome.
# GO_process	GO:0046825	regulation of protein export from nucleus; IBA:GO_Central.
# GO_process	GO:0051028	mRNA transport; IEA:UniProtKB-KW.
# GO_process	GO:0075733	intracellular transport of virus; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005635	nuclear envelope
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005730	nucleolus
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0003723	RNA binding
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# GOslim_process	GO:0051276	chromosome organization
# Gene3D	1.25.10.10	-; 3.
# Genevisible	O14980	HS
# HGNC	HGNC:12825	XPO1
# INTERACTION	XPO1_HUMAN	Q9WMX2 - (xeno); NbExp=3; IntAct=EBI-355867, EBI-710918; O15392 BIRC5; NbExp=2; IntAct=EBI-355867, EBI-518823; P04626 ERBB2; NbExp=2; IntAct=EBI-355867, EBI-641062; P35232 PHB; NbExp=2; IntAct=EBI-355867, EBI-354213; P61925 PKIA; NbExp=2; IntAct=EBI-355867, EBI-2682139; P63104 YWHAZ; NbExp=2; IntAct=EBI-355867, EBI-347088; 
# IntAct	O14980	56
# InterPro	IPR001494	Importin-beta_N
# InterPro	IPR011989	ARM-like
# InterPro	IPR013598	Exportin-1/Importin-b-like
# InterPro	IPR014877	CRM1_C_dom
# InterPro	IPR016024	ARM-type_fold
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko03009	 Ribosome biogenesis
# KEGG_Brite	ko03016	 Transfer RNA biogenesis
# KEGG_Brite	ko03036	 Chromosome
# KEGG_Pathway	ko03008	Ribosome biogenesis in eukaryotes
# KEGG_Pathway	ko03013	RNA transport
# KEGG_Pathway	ko05164	Influenza A
# KEGG_Pathway	ko05166	HTLV-I infection
# KEGG_Pathway	ko05169	Epstein-Barr virus infection
# MIM	602559	gene
# MISCELLANEOUS	XPO1_HUMAN	Cellular target of leptomycin B (LMB), a XPO1/CRM1 nuclear export inhibitor. 
# Organism	XPO1_HUMAN	Homo sapiens (Human)
# PDB	1W9C	X-ray; 2.30 A; A/B=707-1027
# PDB	2L1L	NMR; -; B=504-630
# PDB	3GB8	X-ray; 2.90 A; A=1-1071
# PDB	4BSM	X-ray; 4.50 A; A=1-1032
# PDB	4BSN	X-ray; 4.10 A; A=1-1032
# PDB	5DIS	X-ray; 2.85 A; A=5-1048
# PROSITE	PS50166	IMPORTIN_B_NT
# Pfam	PF03810	IBN_N
# Pfam	PF08389	Xpo1
# Pfam	PF08767	CRM1_C
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-165054	Rev-mediated nuclear export of HIV RNA
# Reactome	R-HSA-168333	NEP/NS2 Interacts with the Cellular Export Machinery
# Reactome	R-HSA-2173788	Downregulation of TGF-beta receptor signaling
# Reactome	R-HSA-2467813	Separation of Sister Chromatids
# Reactome	R-HSA-2500257	Resolution of Sister Chromatid Cohesion
# Reactome	R-HSA-3769402	Deactivation of the beta-catenin transactivating complex
# Reactome	R-HSA-450520	HuR (ELAVL1) binds and stabilizes mRNA
# Reactome	R-HSA-5663220	RHO GTPases Activate Formins
# Reactome	R-HSA-5687128	MAPK6/MAPK4 signaling
# Reactome	R-HSA-68877	Mitotic Prometaphase
# Reactome	R-HSA-69273	Cyclin A/B1 associated events during G2/M transition
# RecName	XPO1_HUMAN	Exportin-1
# RefSeq	NP_003391	NM_003400.3
# RefSeq	XP_006712157	XM_006712094.2
# RefSeq	XP_011531399	XM_011533097.1
# SIMILARITY	Belongs to the exportin family. {ECO	0000305}. 
# SIMILARITY	Contains 1 importin N-terminal domain. {ECO:0000255|PROSITE-ProRule	PRU00115}. 
# SIMILARITY	Contains 10 HEAT repeats. {ECO	0000305}. 
# SMART	SM00913	IBN_N
# SMART	SM01102	CRM1_C
# SUBCELLULAR LOCATION	XPO1_HUMAN	Cytoplasm. Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus, nucleolus. Note=Located in the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm. 
# SUBUNIT	XPO1_HUMAN	Found in a U snRNA export complex with PHAX/RNUXA, NCBP1/CBP80, NCBP2/CBP20, RAN, XPO1 and m7G-capped RNA (By similarity). Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, RAN and XPO1. Found in a nuclear export complex with RANBP3 and RAN. Found in a 60S ribosomal subunit export complex with NMD3, RAN, XPO1. Interacts with DDX3X, NMD3, NUPL2, NUP88, NUP214, RANBP3 and TERT. Also found in complex with several viral proteins involved in RNAs' nuclear export like HIV-1 Rev and HTLV-1 Rex. Interacts presumably with influenza A nucleoprotein. Interacts with Epstein-Barr virus BMLF1. Interacts with NEMF (via its N-terminus). Interacts with the monomeric form of BIRC5/survivin deacetylated at 'Lys-129'. Interacts with DTNBP1 and SERTAD2; the interactions translocate DTNBP1 and SERTAD2 out of the nucleus. Interacts with ATF2. Interacts with SLC35G1 and STIM1. Interacts with DCAF8. Interacts with CPEB3 (PubMed 22730302). Interacts with HAX1 (PubMed 23164465). Interacts with BOK; translocates to the cytoplasm (PubMed 16302269). {ECO 0000250|UniProtKB Q6P5F9, ECO 0000269|PubMed 10209022, ECO 0000269|PubMed 10358091, ECO 0000269|PubMed 10400785, ECO 0000269|PubMed 11119609, ECO 0000269|PubMed 11425870, ECO 0000269|PubMed 11571268, ECO 0000269|PubMed 11932251, ECO 0000269|PubMed 12134013, ECO 0000269|PubMed 12724356, ECO 0000269|PubMed 12808100, ECO 0000269|PubMed 14612415, ECO 0000269|PubMed 15507209, ECO 0000269|PubMed 15574331, ECO 0000269|PubMed 15632073, ECO 0000269|PubMed 16103875, ECO 0000269|PubMed 16302269, ECO 0000269|PubMed 18316374, ECO 0000269|PubMed 20826784, ECO 0000269|PubMed 20921223, ECO 0000269|PubMed 22084111, ECO 0000269|PubMed 22275354, ECO 0000269|PubMed 22500989, ECO 0000269|PubMed 22730302, ECO 0000269|PubMed 23164465, ECO 0000269|PubMed 9049309, ECO 0000269|PubMed 9323133, ECO 0000269|PubMed 9837918}. 
# SUPFAM	SSF48371	SSF48371; 4
# TCDB	1.I.1.1	the nuclear pore complex (npc) family
# TISSUE SPECIFICITY	XPO1_HUMAN	Expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. Not expressed in the kidney. {ECO 0000269|PubMed 9049309, ECO 0000269|PubMed 9368044}. 
# UCSC	uc002sbj	human
# WEB RESOURCE	XPO1_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/XPO1ID44168ch2p15.html";
# eggNOG	COG5101	LUCA
# eggNOG	KOG2020	Eukaryota
BLAST	swissprot:XPO1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:XPO1_HUMAN
BioCyc	ZFISH:ENSG00000082898-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000082898-MONOMER
COXPRESdb	7514	http://coxpresdb.jp/data/gene/7514.shtml
CleanEx	HS_XPO1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_XPO1
DIP	DIP-33678N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-33678N
DOI	10.1002/mc.20156	http://dx.doi.org/10.1002/mc.20156
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/S0092-8674(00)80371-2	http://dx.doi.org/10.1016/S0092-8674(00)80371-2
DOI	10.1016/j.cell.2004.09.029	http://dx.doi.org/10.1016/j.cell.2004.09.029
DOI	10.1016/j.febslet.2012.02.053	http://dx.doi.org/10.1016/j.febslet.2012.02.053
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.molcel.2004.11.013	http://dx.doi.org/10.1016/j.molcel.2004.11.013
DOI	10.1016/j.molcel.2004.11.018	http://dx.doi.org/10.1016/j.molcel.2004.11.018
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/nbt1240	http://dx.doi.org/10.1038/nbt1240
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.onc.1208962	http://dx.doi.org/10.1038/sj.onc.1208962
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.1117231108	http://dx.doi.org/10.1073/pnas.1117231108
DOI	10.1073/pnas.96.16.9112	http://dx.doi.org/10.1073/pnas.96.16.9112
DOI	10.1074/jbc.272.47.29742	http://dx.doi.org/10.1074/jbc.272.47.29742
DOI	10.1074/jbc.273.50.33414	http://dx.doi.org/10.1074/jbc.273.50.33414
DOI	10.1074/jbc.274.24.17309	http://dx.doi.org/10.1074/jbc.274.24.17309
DOI	10.1074/jbc.C100620200	http://dx.doi.org/10.1074/jbc.C100620200
DOI	10.1074/jbc.M110.107912	http://dx.doi.org/10.1074/jbc.M110.107912
DOI	10.1074/jbc.M110.152777	http://dx.doi.org/10.1074/jbc.M110.152777
DOI	10.1074/jbc.M111.294272	http://dx.doi.org/10.1074/jbc.M111.294272
DOI	10.1074/jbc.M708365200	http://dx.doi.org/10.1074/jbc.M708365200
DOI	10.1083/jcb.145.2.255	http://dx.doi.org/10.1083/jcb.145.2.255
DOI	10.1083/jcb.153.7.1391	http://dx.doi.org/10.1083/jcb.153.7.1391
DOI	10.1093/embo-reports/kve200	http://dx.doi.org/10.1093/embo-reports/kve200
DOI	10.1093/emboj/16.4.807	http://dx.doi.org/10.1093/emboj/16.4.807
DOI	10.1093/nar/gks598	http://dx.doi.org/10.1093/nar/gks598
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/febs.12066	http://dx.doi.org/10.1111/febs.12066
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1126/science.278.5335.141	http://dx.doi.org/10.1126/science.278.5335.141
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1128/JVI.75.1.408-419.2001	http://dx.doi.org/10.1128/JVI.75.1.408-419.2001
DOI	10.1128/JVI.76.16.8079-8089.2002	http://dx.doi.org/10.1128/JVI.76.16.8079-8089.2002
DOI	10.1128/MCB.23.13.4598-4610.2003	http://dx.doi.org/10.1128/MCB.23.13.4598-4610.2003
DOI	10.1128/MCB.23.23.8751-8761.2003	http://dx.doi.org/10.1128/MCB.23.23.8751-8761.2003
DOI	10.1128/MCB.25.2.728-739.2005	http://dx.doi.org/10.1128/MCB.25.2.728-739.2005
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1242/jcs.00464	http://dx.doi.org/10.1242/jcs.00464
EMBL	AC016727	http://www.ebi.ac.uk/ena/data/view/AC016727
EMBL	AK289920	http://www.ebi.ac.uk/ena/data/view/AK289920
EMBL	BC032847	http://www.ebi.ac.uk/ena/data/view/BC032847
EMBL	BX647758	http://www.ebi.ac.uk/ena/data/view/BX647758
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
EMBL	CR749840	http://www.ebi.ac.uk/ena/data/view/CR749840
EMBL	D89729	http://www.ebi.ac.uk/ena/data/view/D89729
EMBL	Y08614	http://www.ebi.ac.uk/ena/data/view/Y08614
Ensembl	ENST00000401558	http://www.ensembl.org/id/ENST00000401558
Ensembl	ENST00000404992	http://www.ensembl.org/id/ENST00000404992
Ensembl	ENST00000406957	http://www.ensembl.org/id/ENST00000406957
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000776	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000776
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GO_component	GO:0005642	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005642
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005730
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0015030	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015030
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0030529	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030529
GO_component	GO:0031965	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031965
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0003723	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723
GO_function	GO:0005049	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005049
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0005487	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005487
GO_process	GO:0000055	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000055
GO_process	GO:0000056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000056
GO_process	GO:0000122	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000122
GO_process	GO:0006611	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006611
GO_process	GO:0007062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007062
GO_process	GO:0010824	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010824
GO_process	GO:0016032	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016032
GO_process	GO:0034504	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034504
GO_process	GO:0042176	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042176
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0043488	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043488
GO_process	GO:0046825	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046825
GO_process	GO:0051028	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051028
GO_process	GO:0075733	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0075733
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005730
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0003723	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
GOslim_process	GO:0051276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
GeneCards	XPO1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=XPO1
GeneID	7514	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7514
GeneTree	ENSGT00390000000572	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000000572
HGNC	HGNC:12825	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:12825
HOVERGEN	HBG052817	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052817&db=HOVERGEN
HPA	CAB010184	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB010184
HPA	HPA042933	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042933
InParanoid	O14980	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O14980
IntAct	O14980	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O14980*
InterPro	IPR001494	http://www.ebi.ac.uk/interpro/entry/IPR001494
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR013598	http://www.ebi.ac.uk/interpro/entry/IPR013598
InterPro	IPR014877	http://www.ebi.ac.uk/interpro/entry/IPR014877
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
Jabion	7514	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7514
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko03009	http://www.genome.jp/dbget-bin/www_bget?ko03009
KEGG_Brite	ko03016	http://www.genome.jp/dbget-bin/www_bget?ko03016
KEGG_Brite	ko03036	http://www.genome.jp/dbget-bin/www_bget?ko03036
KEGG_Gene	hsa:7514	http://www.genome.jp/dbget-bin/www_bget?hsa:7514
KEGG_Orthology	KO:K14290	http://www.genome.jp/dbget-bin/www_bget?KO:K14290
KEGG_Pathway	ko03008	http://www.genome.jp/kegg-bin/show_pathway?ko03008
KEGG_Pathway	ko03013	http://www.genome.jp/kegg-bin/show_pathway?ko03013
KEGG_Pathway	ko05164	http://www.genome.jp/kegg-bin/show_pathway?ko05164
KEGG_Pathway	ko05166	http://www.genome.jp/kegg-bin/show_pathway?ko05166
KEGG_Pathway	ko05169	http://www.genome.jp/kegg-bin/show_pathway?ko05169
MIM	602559	http://www.ncbi.nlm.nih.gov/omim/602559
MINT	MINT-5002192	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5002192
OMA	TFIKIAL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TFIKIAL
OrthoDB	EOG091G013G	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G013G
PDB	1W9C	http://www.ebi.ac.uk/pdbe-srv/view/entry/1W9C
PDB	2L1L	http://www.ebi.ac.uk/pdbe-srv/view/entry/2L1L
PDB	3GB8	http://www.ebi.ac.uk/pdbe-srv/view/entry/3GB8
PDB	4BSM	http://www.ebi.ac.uk/pdbe-srv/view/entry/4BSM
PDB	4BSN	http://www.ebi.ac.uk/pdbe-srv/view/entry/4BSN
PDB	5DIS	http://www.ebi.ac.uk/pdbe-srv/view/entry/5DIS
PDBsum	1W9C	http://www.ebi.ac.uk/pdbsum/1W9C
PDBsum	2L1L	http://www.ebi.ac.uk/pdbsum/2L1L
PDBsum	3GB8	http://www.ebi.ac.uk/pdbsum/3GB8
PDBsum	4BSM	http://www.ebi.ac.uk/pdbsum/4BSM
PDBsum	4BSN	http://www.ebi.ac.uk/pdbsum/4BSN
PDBsum	5DIS	http://www.ebi.ac.uk/pdbsum/5DIS
PROSITE	PS50166	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50166
PSORT	swissprot:XPO1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:XPO1_HUMAN
PSORT-B	swissprot:XPO1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:XPO1_HUMAN
PSORT2	swissprot:XPO1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:XPO1_HUMAN
Pfam	PF03810	http://pfam.xfam.org/family/PF03810
Pfam	PF08389	http://pfam.xfam.org/family/PF08389
Pfam	PF08767	http://pfam.xfam.org/family/PF08767
PharmGKB	PA37418	http://www.pharmgkb.org/do/serve?objId=PA37418&objCls=Gene
Phobius	swissprot:XPO1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:XPO1_HUMAN
PhylomeDB	O14980	http://phylomedb.org/?seqid=O14980
ProteinModelPortal	O14980	http://www.proteinmodelportal.org/query/uniprot/O14980
PubMed	10209022	http://www.ncbi.nlm.nih.gov/pubmed/10209022
PubMed	10358091	http://www.ncbi.nlm.nih.gov/pubmed/10358091
PubMed	10400785	http://www.ncbi.nlm.nih.gov/pubmed/10400785
PubMed	10430904	http://www.ncbi.nlm.nih.gov/pubmed/10430904
PubMed	11119609	http://www.ncbi.nlm.nih.gov/pubmed/11119609
PubMed	11425870	http://www.ncbi.nlm.nih.gov/pubmed/11425870
PubMed	11571268	http://www.ncbi.nlm.nih.gov/pubmed/11571268
PubMed	11932251	http://www.ncbi.nlm.nih.gov/pubmed/11932251
PubMed	12134013	http://www.ncbi.nlm.nih.gov/pubmed/12134013
PubMed	12724356	http://www.ncbi.nlm.nih.gov/pubmed/12724356
PubMed	12808100	http://www.ncbi.nlm.nih.gov/pubmed/12808100
PubMed	14612415	http://www.ncbi.nlm.nih.gov/pubmed/14612415
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15507209	http://www.ncbi.nlm.nih.gov/pubmed/15507209
PubMed	15574331	http://www.ncbi.nlm.nih.gov/pubmed/15574331
PubMed	15574332	http://www.ncbi.nlm.nih.gov/pubmed/15574332
PubMed	15632073	http://www.ncbi.nlm.nih.gov/pubmed/15632073
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	16103875	http://www.ncbi.nlm.nih.gov/pubmed/16103875
PubMed	16302269	http://www.ncbi.nlm.nih.gov/pubmed/16302269
PubMed	16964243	http://www.ncbi.nlm.nih.gov/pubmed/16964243
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18316374	http://www.ncbi.nlm.nih.gov/pubmed/18316374
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	20826784	http://www.ncbi.nlm.nih.gov/pubmed/20826784
PubMed	20921223	http://www.ncbi.nlm.nih.gov/pubmed/20921223
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22084111	http://www.ncbi.nlm.nih.gov/pubmed/22084111
PubMed	22275354	http://www.ncbi.nlm.nih.gov/pubmed/22275354
PubMed	22500989	http://www.ncbi.nlm.nih.gov/pubmed/22500989
PubMed	22730302	http://www.ncbi.nlm.nih.gov/pubmed/22730302
PubMed	23164465	http://www.ncbi.nlm.nih.gov/pubmed/23164465
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	9049309	http://www.ncbi.nlm.nih.gov/pubmed/9049309
PubMed	9311922	http://www.ncbi.nlm.nih.gov/pubmed/9311922
PubMed	9323133	http://www.ncbi.nlm.nih.gov/pubmed/9323133
PubMed	9368044	http://www.ncbi.nlm.nih.gov/pubmed/9368044
PubMed	9837918	http://www.ncbi.nlm.nih.gov/pubmed/9837918
Reactome	R-HSA-165054	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-165054
Reactome	R-HSA-168333	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-168333
Reactome	R-HSA-2173788	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2173788
Reactome	R-HSA-2467813	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2467813
Reactome	R-HSA-2500257	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2500257
Reactome	R-HSA-3769402	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3769402
Reactome	R-HSA-450520	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-450520
Reactome	R-HSA-5663220	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5663220
Reactome	R-HSA-5687128	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5687128
Reactome	R-HSA-68877	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-68877
Reactome	R-HSA-69273	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-69273
RefSeq	NP_003391	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003391
RefSeq	XP_006712157	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006712157
RefSeq	XP_011531399	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011531399
SMART	SM00913	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00913
SMART	SM01102	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01102
SMR	O14980	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O14980
STRING	9606.ENSP00000384863	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000384863&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
TCDB	1.I.1.1	http://www.tcdb.org/search/result.php?tc=1.I.1.1
UCSC	uc002sbj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002sbj&org=rat
UniGene	Hs.370770	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.370770
UniProtKB	XPO1_HUMAN	http://www.uniprot.org/uniprot/XPO1_HUMAN
UniProtKB-AC	O14980	http://www.uniprot.org/uniprot/O14980
charge	swissprot:XPO1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:XPO1_HUMAN
eggNOG	COG5101	http://eggnogapi.embl.de/nog_data/html/tree/COG5101
eggNOG	KOG2020	http://eggnogapi.embl.de/nog_data/html/tree/KOG2020
epestfind	swissprot:XPO1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:XPO1_HUMAN
garnier	swissprot:XPO1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:XPO1_HUMAN
helixturnhelix	swissprot:XPO1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:XPO1_HUMAN
hmoment	swissprot:XPO1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:XPO1_HUMAN
iep	swissprot:XPO1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:XPO1_HUMAN
inforesidue	swissprot:XPO1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:XPO1_HUMAN
neXtProt	NX_O14980	http://www.nextprot.org/db/entry/NX_O14980
octanol	swissprot:XPO1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:XPO1_HUMAN
pepcoil	swissprot:XPO1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:XPO1_HUMAN
pepdigest	swissprot:XPO1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:XPO1_HUMAN
pepinfo	swissprot:XPO1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:XPO1_HUMAN
pepnet	swissprot:XPO1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:XPO1_HUMAN
pepstats	swissprot:XPO1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:XPO1_HUMAN
pepwheel	swissprot:XPO1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:XPO1_HUMAN
pepwindow	swissprot:XPO1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:XPO1_HUMAN
sigcleave	swissprot:XPO1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:XPO1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ABCA3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99758-1; Sequence=Displayed; Name=2; IsoId=Q99758-2; Sequence=VSP_056262, VSP_056263; Note=No experimental confirmation available.; 
# AltName	ABCA3_HUMAN	ABC-C transporter
# AltName	ABCA3_HUMAN	ATP-binding cassette transporter 3
# BioGrid	106539	25
# CCDS	CCDS10466	-. [Q99758-1]
# ChiTaRS	ABCA3	human
# DISEASE	ABCA3_HUMAN	Pulmonary surfactant metabolism dysfunction 3 (SMDP3) [MIM 610921]  A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid- Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. {ECO 0000269|PubMed 15044640}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	ABCA3_HUMAN	Multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. {ECO 0000250}. 
# DrugBank	DB00619	Imatinib
# Ensembl	ENST00000301732	ENSP00000301732; ENSG00000167972. [Q99758-1]
# Ensembl	ENST00000567910	ENSP00000454397; ENSG00000167972. [Q99758-2]
# ExpressionAtlas	Q99758	baseline and differential
# FUNCTION	ABCA3_HUMAN	Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol. 
# GO_component	GO:0005615	extracellular space; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:MGI.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_component	GO:0097208	alveolar lamellar body; IDA:MGI.
# GO_component	GO:0097232	lamellar body membrane; TAS:Reactome.
# GO_component	GO:0097233	alveolar lamellar body membrane; IEA:Ensembl.
# GO_function	GO:0005215	transporter activity; TAS:ProtInc.
# GO_function	GO:0005319	lipid transporter activity; TAS:Reactome.
# GO_function	GO:0005524	ATP binding; TAS:ProtInc.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; TAS:ProtInc.
# GO_process	GO:0006810	transport; IDA:MGI.
# GO_process	GO:0006869	lipid transport; IBA:GO_Central.
# GO_process	GO:0042493	response to drug; TAS:ProtInc.
# GO_process	GO:0044267	cellular protein metabolic process; TAS:Reactome.
# GO_process	GO:0051384	response to glucocorticoid; IEA:Ensembl.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005615	extracellular space
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 2.
# Genevisible	Q99758	HS
# HGNC	HGNC:33	ABCA3
# IntAct	Q99758	2
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR026082	ABC_A
# InterPro	IPR026969	ABCA3
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Disease	H00217	[Inherited metabolic disease; Respiratory disease] Pulmonary surfactant metabolism dysfunction (SMDP)
# KEGG_Pathway	ko02010	ABC transporters
# MIM	601615	gene
# MIM	610921	phenotype
# Organism	ABCA3_HUMAN	Homo sapiens (Human)
# Orphanet	217563	Neonatal acute respiratory distress with surfactant metabolism deficiency
# Orphanet	264675	Congenital pulmonary alveolar proteinosis
# PANTHER	PTHR19229	PTHR19229
# PANTHER	PTHR19229:SF98	PTHR19229:SF98
# PIR	A59188	A59188
# PIR	S71363	S71363
# PROSITE	PS00211	ABC_TRANSPORTER_1
# PROSITE	PS50893	ABC_TRANSPORTER_2; 2
# Pfam	PF00005	ABC_tran; 2
# Proteomes	UP000005640	Chromosome 16
# Reactome	R-HSA-1369062	ABC transporters in lipid homeostasis
# Reactome	R-HSA-5683826	Surfactant metabolism
# RecName	ABCA3_HUMAN	ATP-binding cassette sub-family A member 3
# RefSeq	NP_001080	NM_001089.2. [Q99758-1]
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCA family. {ECO	0000305}. 
# SIMILARITY	Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA; 2
# SUBCELLULAR LOCATION	ABCA3_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF52540	SSF52540; 2
# TCDB	3.A.1.211	the atp-binding cassette (abc) superfamily
# TISSUE SPECIFICITY	ABCA3_HUMAN	Highly expressed in lung, followed by brain, pancreas, skeletal muscle and heart. Weakly expressed in placenta, kidney and liver. Also expressed in medullary thyroid carcinoma cells (MTC) and in C-cell carcinoma. 
# UCSC	uc002cpy	human. [Q99758-1]
# WEB RESOURCE	ABCA3_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=Q99758";
# WEB RESOURCE	ABCA3_HUMAN	Name=SeattleSNPs; URL="http //pga.gs.washington.edu/data/abca3/"; 
# eggNOG	COG1131	LUCA
# eggNOG	KOG0059	Eukaryota
BLAST	swissprot:ABCA3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCA3_HUMAN
BioCyc	ZFISH:ENSG00000167972-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000167972-MONOMER
COXPRESdb	21	http://coxpresdb.jp/data/gene/21.shtml
CleanEx	HS_ABCA3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCA3
DOI	10.1006/geno.1996.4500	http://dx.doi.org/10.1006/geno.1996.4500
DOI	10.1016/0014-5793(96)00700-4	http://dx.doi.org/10.1016/0014-5793(96)00700-4
DOI	10.1016/S0014-5793(01)03056-3	http://dx.doi.org/10.1016/S0014-5793(01)03056-3
DOI	10.1038/nature03187	http://dx.doi.org/10.1038/nature03187
DOI	10.1056/NEJMoa032178	http://dx.doi.org/10.1056/NEJMoa032178
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DrugBank	DB00619	http://www.drugbank.ca/drugs/DB00619
EMBL	AB070929	http://www.ebi.ac.uk/ena/data/view/AB070929
EMBL	AC009065	http://www.ebi.ac.uk/ena/data/view/AC009065
EMBL	AC098805	http://www.ebi.ac.uk/ena/data/view/AC098805
EMBL	AC106820	http://www.ebi.ac.uk/ena/data/view/AC106820
EMBL	BC020724	http://www.ebi.ac.uk/ena/data/view/BC020724
EMBL	BC062779	http://www.ebi.ac.uk/ena/data/view/BC062779
EMBL	BC140895	http://www.ebi.ac.uk/ena/data/view/BC140895
EMBL	BC146866	http://www.ebi.ac.uk/ena/data/view/BC146866
EMBL	CH471112	http://www.ebi.ac.uk/ena/data/view/CH471112
EMBL	DQ073080	http://www.ebi.ac.uk/ena/data/view/DQ073080
EMBL	U78735	http://www.ebi.ac.uk/ena/data/view/U78735
EMBL	X97187	http://www.ebi.ac.uk/ena/data/view/X97187
Ensembl	ENST00000301732	http://www.ensembl.org/id/ENST00000301732
Ensembl	ENST00000567910	http://www.ensembl.org/id/ENST00000567910
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005615
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0097208	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097208
GO_component	GO:0097232	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097232
GO_component	GO:0097233	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097233
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0005319	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005319
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006869	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006869
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0044267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044267
GO_process	GO:0051384	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051384
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005615
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCA3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCA3
GeneID	21	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=21
GeneTree	ENSGT00760000118965	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118965
HGNC	HGNC:33	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:33
HOGENOM	HOG000006613	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006613&db=HOGENOM6
HOVERGEN	HBG050435	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050435&db=HOVERGEN
HPA	HPA007884	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA007884
InParanoid	Q99758	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q99758
IntAct	Q99758	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q99758*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR026082	http://www.ebi.ac.uk/interpro/entry/IPR026082
InterPro	IPR026969	http://www.ebi.ac.uk/interpro/entry/IPR026969
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	21	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=21
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Disease	H00217	http://www.genome.jp/dbget-bin/www_bget?H00217
KEGG_Gene	hsa:21	http://www.genome.jp/dbget-bin/www_bget?hsa:21
KEGG_Orthology	KO:K05643	http://www.genome.jp/dbget-bin/www_bget?KO:K05643
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
MIM	601615	http://www.ncbi.nlm.nih.gov/omim/601615
MIM	610921	http://www.ncbi.nlm.nih.gov/omim/610921
MINT	MINT-6943242	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6943242
OMA	DWAVDSS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DWAVDSS
Orphanet	217563	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=217563
Orphanet	264675	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=264675
OrthoDB	EOG091G009X	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G009X
PANTHER	PTHR19229	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19229
PANTHER	PTHR19229:SF98	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19229:SF98
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PSORT	swissprot:ABCA3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCA3_HUMAN
PSORT-B	swissprot:ABCA3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCA3_HUMAN
PSORT2	swissprot:ABCA3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCA3_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
PharmGKB	PA24378	http://www.pharmgkb.org/do/serve?objId=PA24378&objCls=Gene
Phobius	swissprot:ABCA3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCA3_HUMAN
PhylomeDB	Q99758	http://phylomedb.org/?seqid=Q99758
ProteinModelPortal	Q99758	http://www.proteinmodelportal.org/query/uniprot/Q99758
PubMed	11718719	http://www.ncbi.nlm.nih.gov/pubmed/11718719
PubMed	15044640	http://www.ncbi.nlm.nih.gov/pubmed/15044640
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15616553	http://www.ncbi.nlm.nih.gov/pubmed/15616553
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	8706931	http://www.ncbi.nlm.nih.gov/pubmed/8706931
PubMed	9027511	http://www.ncbi.nlm.nih.gov/pubmed/9027511
Reactome	R-HSA-1369062	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1369062
Reactome	R-HSA-5683826	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5683826
RefSeq	NP_001080	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001080
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	Q99758	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q99758
STRING	9606.ENSP00000301732	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000301732&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TCDB	3.A.1.211	http://www.tcdb.org/search/result.php?tc=3.A.1.211
UCSC	uc002cpy	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002cpy&org=rat
UniGene	Hs.26630	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.26630
UniProtKB	ABCA3_HUMAN	http://www.uniprot.org/uniprot/ABCA3_HUMAN
UniProtKB-AC	Q99758	http://www.uniprot.org/uniprot/Q99758
charge	swissprot:ABCA3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCA3_HUMAN
eggNOG	COG1131	http://eggnogapi.embl.de/nog_data/html/tree/COG1131
eggNOG	KOG0059	http://eggnogapi.embl.de/nog_data/html/tree/KOG0059
epestfind	swissprot:ABCA3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCA3_HUMAN
garnier	swissprot:ABCA3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCA3_HUMAN
helixturnhelix	swissprot:ABCA3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCA3_HUMAN
hmoment	swissprot:ABCA3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCA3_HUMAN
iep	swissprot:ABCA3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCA3_HUMAN
inforesidue	swissprot:ABCA3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCA3_HUMAN
neXtProt	NX_Q99758	http://www.nextprot.org/db/entry/NX_Q99758
octanol	swissprot:ABCA3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCA3_HUMAN
pepcoil	swissprot:ABCA3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCA3_HUMAN
pepdigest	swissprot:ABCA3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCA3_HUMAN
pepinfo	swissprot:ABCA3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCA3_HUMAN
pepnet	swissprot:ABCA3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCA3_HUMAN
pepstats	swissprot:ABCA3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCA3_HUMAN
pepwheel	swissprot:ABCA3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCA3_HUMAN
pepwindow	swissprot:ABCA3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCA3_HUMAN
sigcleave	swissprot:ABCA3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCA3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=GRM7_v1, mGluR7a; IsoId=Q14831-1; Sequence=Displayed; Name=2; Synonyms=GRM7_v2, mGluR7b; IsoId=Q14831-2; Sequence=VSP_015735; Name=3; Synonyms=GRM7_v3; IsoId=Q14831-3; Sequence=VSP_015732; Note=Ref.4 (AAM47557) sequence differs from that shown due to a frameshift in position 904. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO	0000305}; Name=4; Synonyms=GRM7_v4; IsoId=Q14831-4; Sequence=VSP_015733; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=5; Synonyms=GRM7_v5; IsoId=Q14831-5; Sequence=VSP_015734; 
# BioGrid	109174	5
# CCDS	CCDS43042	-. [Q14831-1]
# ChiTaRS	GRM7	human
# Ensembl	ENST00000357716	ENSP00000350348; ENSG00000196277. [Q14831-1]
# Ensembl	ENST00000389335	ENSP00000373986; ENSG00000196277. [Q14831-4]
# Ensembl	ENST00000389336	ENSP00000373987; ENSG00000196277. [Q14831-5]
# Ensembl	ENST00000467425	ENSP00000419835; ENSG00000196277. [Q14831-2]
# Ensembl	ENST00000486284	ENSP00000417536; ENSG00000196277. [Q14831-2]
# ExpressionAtlas	Q14831	baseline and differential
# FUNCTION	GRM7_HUMAN	G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. {ECO 0000269|PubMed 9473604}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; NAS:UniProtKB.
# GO_component	GO:0005938	cell cortex; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IDA:UniProtKB.
# GO_component	GO:0030424	axon; ISS:UniProtKB.
# GO_component	GO:0030425	dendrite; IDA:UniProtKB.
# GO_component	GO:0032279	asymmetric synapse; ISS:UniProtKB.
# GO_component	GO:0042734	presynaptic membrane; IBA:GO_Central.
# GO_component	GO:0043198	dendritic shaft; ISS:UniProtKB.
# GO_component	GO:0043235	receptor complex; IDA:MGI.
# GO_component	GO:0045211	postsynaptic membrane; ISS:UniProtKB.
# GO_component	GO:0048786	presynaptic active zone; ISS:UniProtKB.
# GO_function	GO:0001642	group III metabotropic glutamate receptor activity; IDA:UniProtKB.
# GO_function	GO:0005245	voltage-gated calcium channel activity; IEA:Ensembl.
# GO_function	GO:0005246	calcium channel regulator activity; IBA:GO_Central.
# GO_function	GO:0005509	calcium ion binding; IDA:UniProtKB.
# GO_function	GO:0008066	glutamate receptor activity; IDA:UniProtKB.
# GO_function	GO:0010855	adenylate cyclase inhibitor activity; IDA:UniProtKB.
# GO_function	GO:0016595	glutamate binding; IDA:UniProtKB.
# GO_function	GO:0030165	PDZ domain binding; NAS:UniProtKB.
# GO_function	GO:0070905	serine binding; IDA:UniProtKB.
# GO_process	GO:0001661	conditioned taste aversion; IEA:Ensembl.
# GO_process	GO:0007194	negative regulation of adenylate cyclase activity; IDA:UniProtKB.
# GO_process	GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway; IDA:UniProtKB.
# GO_process	GO:0007268	chemical synaptic transmission; IDA:UniProtKB.
# GO_process	GO:0007605	sensory perception of sound; IMP:UniProtKB.
# GO_process	GO:0007608	sensory perception of smell; IEA:UniProtKB-KW.
# GO_process	GO:0007614	short-term memory; IEA:Ensembl.
# GO_process	GO:0014050	negative regulation of glutamate secretion; ISS:UniProtKB.
# GO_process	GO:0019226	transmission of nerve impulse; IEA:Ensembl.
# GO_process	GO:0030534	adult behavior; IEA:Ensembl.
# GO_process	GO:0030818	negative regulation of cAMP biosynthetic process; IDA:UniProtKB.
# GO_process	GO:0033555	multicellular organismal response to stress; IEA:Ensembl.
# GO_process	GO:0051966	regulation of synaptic transmission, glutamatergic; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0030234	enzyme regulator activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# Genevisible	Q14831	HS
# HGNC	HGNC:4599	GRM7
# InterPro	IPR000162	GPCR_3_mtglu_rcpt
# InterPro	IPR000337	GPCR_3
# InterPro	IPR001828	ANF_lig-bd_rcpt
# InterPro	IPR001883	GPCR_3_mtglu_rcpt_7
# InterPro	IPR011500	GPCR_3_9-Cys_dom
# InterPro	IPR017978	GPCR_3_C
# InterPro	IPR017979	GPCR_3_CS
# InterPro	IPR028082	Peripla_BP_I
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04030	 G protein-coupled receptors
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04724	Glutamatergic synapse
# MIM	604101	gene
# Organism	GRM7_HUMAN	Homo sapiens (Human)
# PDB	3MQ4	X-ray; 2.80 A; A=37-513
# PDB	5C5C	X-ray; 1.86 A; A=37-513
# PRINTS	PR00248	GPCRMGR
# PRINTS	PR00593	MTABOTROPICR
# PRINTS	PR01057	MTABOTROPC7R
# PROSITE	PS00979	G_PROTEIN_RECEP_F3_1
# PROSITE	PS00980	G_PROTEIN_RECEP_F3_2
# PROSITE	PS00981	G_PROTEIN_RECEP_F3_3
# PROSITE	PS50259	G_PROTEIN_RECEP_F3_4
# Pfam	PF00003	7tm_3
# Pfam	PF01094	ANF_receptor
# Pfam	PF07562	NCD3G
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-418594	G alpha (i) signalling events
# Reactome	R-HSA-420499	Class C/3 (Metabotropic glutamate/pheromone receptors)
# RecName	GRM7_HUMAN	Metabotropic glutamate receptor 7
# RefSeq	NP_000835	NM_000844.3. [Q14831-1]
# RefSeq	NP_870989	NM_181874.2. [Q14831-2]
# SIMILARITY	Belongs to the G-protein coupled receptor 3 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	GRM7_HUMAN	Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Interacts with PICK1. {ECO	0000250}. 
# SUPFAM	SSF53822	SSF53822
# TISSUE SPECIFICITY	GRM7_HUMAN	Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4. {ECO 0000269|PubMed 12052533, ECO 0000269|PubMed 8840028}. 
# UCSC	uc003bql	human. [Q14831-1]
# eggNOG	ENOG410XR6W	LUCA
# eggNOG	KOG1056	Eukaryota
BLAST	swissprot:GRM7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GRM7_HUMAN
BioCyc	ZFISH:G66-33332-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33332-MONOMER
COXPRESdb	2917	http://coxpresdb.jp/data/gene/2917.shtml
CleanEx	HS_GRM7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GRM7
DOI	10.1016/0169-328X(96)00110-6	http://dx.doi.org/10.1016/0169-328X(96)00110-6
DOI	10.1016/S0028-3908(96)00176-1	http://dx.doi.org/10.1016/S0028-3908(96)00176-1
DOI	10.1016/S0169-328X(97)00277-5	http://dx.doi.org/10.1016/S0169-328X(97)00277-5
DOI	10.1016/S0304-3940(02)00306-3	http://dx.doi.org/10.1016/S0304-3940(02)00306-3
DOI	10.1016/S0920-9964(99)00235-2	http://dx.doi.org/10.1016/S0920-9964(99)00235-2
EMBL	AF458052	http://www.ebi.ac.uk/ena/data/view/AF458052
EMBL	AF458053	http://www.ebi.ac.uk/ena/data/view/AF458053
EMBL	AF458054	http://www.ebi.ac.uk/ena/data/view/AF458054
EMBL	U92458	http://www.ebi.ac.uk/ena/data/view/U92458
EMBL	X94552	http://www.ebi.ac.uk/ena/data/view/X94552
Ensembl	ENST00000357716	http://www.ensembl.org/id/ENST00000357716
Ensembl	ENST00000389335	http://www.ensembl.org/id/ENST00000389335
Ensembl	ENST00000389336	http://www.ensembl.org/id/ENST00000389336
Ensembl	ENST00000467425	http://www.ensembl.org/id/ENST00000467425
Ensembl	ENST00000486284	http://www.ensembl.org/id/ENST00000486284
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005938	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005938
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030424	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030424
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0032279	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032279
GO_component	GO:0042734	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042734
GO_component	GO:0043198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043198
GO_component	GO:0043235	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043235
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_component	GO:0048786	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048786
GO_function	GO:0001642	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001642
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0005246	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005246
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0008066	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008066
GO_function	GO:0010855	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010855
GO_function	GO:0016595	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016595
GO_function	GO:0030165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030165
GO_function	GO:0070905	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070905
GO_process	GO:0001661	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001661
GO_process	GO:0007194	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007194
GO_process	GO:0007196	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007196
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007605
GO_process	GO:0007608	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007608
GO_process	GO:0007614	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007614
GO_process	GO:0014050	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014050
GO_process	GO:0019226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019226
GO_process	GO:0030534	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030534
GO_process	GO:0030818	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030818
GO_process	GO:0033555	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033555
GO_process	GO:0051966	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051966
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0030234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	GRM7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GRM7
GeneID	2917	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2917
GeneTree	ENSGT00760000118884	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118884
HGNC	HGNC:4599	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4599
HOGENOM	HOG000218635	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218635&db=HOGENOM6
HOVERGEN	HBG107965	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG107965&db=HOVERGEN
HPA	HPA015964	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA015964
HPA	HPA036659	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA036659
InParanoid	Q14831	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q14831
InterPro	IPR000162	http://www.ebi.ac.uk/interpro/entry/IPR000162
InterPro	IPR000337	http://www.ebi.ac.uk/interpro/entry/IPR000337
InterPro	IPR001828	http://www.ebi.ac.uk/interpro/entry/IPR001828
InterPro	IPR001883	http://www.ebi.ac.uk/interpro/entry/IPR001883
InterPro	IPR011500	http://www.ebi.ac.uk/interpro/entry/IPR011500
InterPro	IPR017978	http://www.ebi.ac.uk/interpro/entry/IPR017978
InterPro	IPR017979	http://www.ebi.ac.uk/interpro/entry/IPR017979
InterPro	IPR028082	http://www.ebi.ac.uk/interpro/entry/IPR028082
Jabion	2917	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2917
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04030	http://www.genome.jp/dbget-bin/www_bget?ko04030
KEGG_Gene	hsa:2917	http://www.genome.jp/dbget-bin/www_bget?hsa:2917
KEGG_Orthology	KO:K04608	http://www.genome.jp/dbget-bin/www_bget?KO:K04608
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
MIM	604101	http://www.ncbi.nlm.nih.gov/omim/604101
OMA	RTGCRSI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RTGCRSI
OrthoDB	EOG091G177R	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G177R
PDB	3MQ4	http://www.ebi.ac.uk/pdbe-srv/view/entry/3MQ4
PDB	5C5C	http://www.ebi.ac.uk/pdbe-srv/view/entry/5C5C
PDBsum	3MQ4	http://www.ebi.ac.uk/pdbsum/3MQ4
PDBsum	5C5C	http://www.ebi.ac.uk/pdbsum/5C5C
PRINTS	PR00248	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00248
PRINTS	PR00593	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00593
PRINTS	PR01057	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01057
PROSITE	PS00979	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00979
PROSITE	PS00980	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00980
PROSITE	PS00981	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00981
PROSITE	PS50259	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50259
PSORT	swissprot:GRM7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GRM7_HUMAN
PSORT-B	swissprot:GRM7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GRM7_HUMAN
PSORT2	swissprot:GRM7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GRM7_HUMAN
Pfam	PF00003	http://pfam.xfam.org/family/PF00003
Pfam	PF01094	http://pfam.xfam.org/family/PF01094
Pfam	PF07562	http://pfam.xfam.org/family/PF07562
PharmGKB	PA28996	http://www.pharmgkb.org/do/serve?objId=PA28996&objCls=Gene
Phobius	swissprot:GRM7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GRM7_HUMAN
PhylomeDB	Q14831	http://phylomedb.org/?seqid=Q14831
ProteinModelPortal	Q14831	http://www.proteinmodelportal.org/query/uniprot/Q14831
PubMed	11163549	http://www.ncbi.nlm.nih.gov/pubmed/11163549
PubMed	12052533	http://www.ncbi.nlm.nih.gov/pubmed/12052533
PubMed	8840028	http://www.ncbi.nlm.nih.gov/pubmed/8840028
PubMed	9144652	http://www.ncbi.nlm.nih.gov/pubmed/9144652
PubMed	9473604	http://www.ncbi.nlm.nih.gov/pubmed/9473604
Reactome	R-HSA-418594	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418594
Reactome	R-HSA-420499	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-420499
RefSeq	NP_000835	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000835
RefSeq	NP_870989	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_870989
SMR	Q14831	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q14831
STRING	9606.ENSP00000350348	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000350348&targetmode=cogs
SUPFAM	SSF53822	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822
UCSC	uc003bql	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003bql&org=rat
UniGene	Hs.606393	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.606393
UniGene	Hs.660131	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.660131
UniProtKB	GRM7_HUMAN	http://www.uniprot.org/uniprot/GRM7_HUMAN
UniProtKB-AC	Q14831	http://www.uniprot.org/uniprot/Q14831
charge	swissprot:GRM7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GRM7_HUMAN
eggNOG	ENOG410XR6W	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XR6W
eggNOG	KOG1056	http://eggnogapi.embl.de/nog_data/html/tree/KOG1056
epestfind	swissprot:GRM7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GRM7_HUMAN
garnier	swissprot:GRM7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GRM7_HUMAN
helixturnhelix	swissprot:GRM7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GRM7_HUMAN
hmoment	swissprot:GRM7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GRM7_HUMAN
iep	swissprot:GRM7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GRM7_HUMAN
inforesidue	swissprot:GRM7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GRM7_HUMAN
neXtProt	NX_Q14831	http://www.nextprot.org/db/entry/NX_Q14831
octanol	swissprot:GRM7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GRM7_HUMAN
pepcoil	swissprot:GRM7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GRM7_HUMAN
pepdigest	swissprot:GRM7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GRM7_HUMAN
pepinfo	swissprot:GRM7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GRM7_HUMAN
pepnet	swissprot:GRM7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GRM7_HUMAN
pepstats	swissprot:GRM7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GRM7_HUMAN
pepwheel	swissprot:GRM7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GRM7_HUMAN
pepwindow	swissprot:GRM7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GRM7_HUMAN
sigcleave	swissprot:GRM7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GRM7_HUMAN
## Database	ID	URL or Descriptions
# AltName	CTR1_HUMAN	Ecotropic retroviral leukemia receptor homolog
# AltName	CTR1_HUMAN	Ecotropic retrovirus receptor homolog
# AltName	CTR1_HUMAN	Solute carrier family 7 member 1
# AltName	CTR1_HUMAN	System Y+ basic amino acid transporter
# BioGrid	112432	59
# ChiTaRS	SLC7A1	human
# DrugBank	DB00123	L-Lysine
# DrugBank	DB00125	L-Arginine
# DrugBank	DB00129	L-Ornithine
# Ensembl	ENST00000380752	ENSP00000370128; ENSG00000139514
# ExpressionAtlas	P30825	baseline and differential
# FUNCTION	CTR1_HUMAN	High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor. {ECO 0000269|PubMed 10485994}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_function	GO:0000064	L-ornithine transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015181	arginine transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015189	L-lysine transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015297	antiporter activity; IBA:GO_Central.
# GO_process	GO:0006810	transport; NAS:ProtInc.
# GO_process	GO:0006865	amino acid transport; TAS:Reactome.
# GO_process	GO:0015809	arginine transport; IEA:Ensembl.
# GO_process	GO:1903352	L-ornithine transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P30825	HS
# HGNC	HGNC:11057	SLC7A1
# INTERACTION	CTR1_HUMAN	Q969F0 FATE1; NbExp=5; IntAct=EBI-4289564, EBI-743099; 
# IntAct	P30825	6
# InterPro	IPR002293	AA/rel_permease1
# InterPro	IPR004755	Cat_AA_permease
# InterPro	IPR029485	CAT_C
# KEGG_Brite	ko02001	Solute carrier family
# MIM	104615	gene
# Organism	CTR1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11785	PTHR11785; 3
# PIR	S29685	S29685
# Pfam	PF13520	AA_permease_2
# Pfam	PF13906	AA_permease_C
# Proteomes	UP000005640	Chromosome 13
# Reactome	R-HSA-352230	Amino acid transport across the plasma membrane
# RecName	CTR1_HUMAN	High affinity cationic amino acid transporter 1
# RefSeq	NP_003036	NM_003045.4
# RefSeq	XP_005266564	XM_005266507.3
# RefSeq	XP_016876205	XM_017020716.1
# SIMILARITY	Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	CTR1_HUMAN	Cell membrane {ECO 0000269|PubMed 10485994}; Multi-pass membrane protein {ECO 0000303|PubMed 10485994}. 
# TCDB	2.A.3.3	the amino acid-polyamine-organocation (apc) family
# TIGRFAMs	TIGR00906	2A0303
# TISSUE SPECIFICITY	Ubiquitous. {ECO:0000269|PubMed	1718082}. 
# UCSC	uc001uso	human
# eggNOG	COG0531	LUCA
# eggNOG	KOG1286	Eukaryota
BLAST	swissprot:CTR1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CTR1_HUMAN
BioCyc	ZFISH:ENSG00000139514-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000139514-MONOMER
COXPRESdb	6541	http://coxpresdb.jp/data/gene/6541.shtml
CleanEx	HS_SLC7A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC7A1
DOI	10.1007/s002329900558	http://dx.doi.org/10.1007/s002329900558
DOI	10.1016/0042-6822(91)90748-Z	http://dx.doi.org/10.1016/0042-6822(91)90748-Z
DOI	10.1016/0888-7543(92)90431-Q	http://dx.doi.org/10.1016/0888-7543(92)90431-Q
DOI	10.1038/nature02379	http://dx.doi.org/10.1038/nature02379
DOI	10.1038/nbt.1532	http://dx.doi.org/10.1038/nbt.1532
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00123	http://www.drugbank.ca/drugs/DB00123
DrugBank	DB00125	http://www.drugbank.ca/drugs/DB00125
DrugBank	DB00129	http://www.drugbank.ca/drugs/DB00129
EMBL	AF078107	http://www.ebi.ac.uk/ena/data/view/AF078107
EMBL	AL596114	http://www.ebi.ac.uk/ena/data/view/AL596114
EMBL	BC063303	http://www.ebi.ac.uk/ena/data/view/BC063303
EMBL	BC069358	http://www.ebi.ac.uk/ena/data/view/BC069358
EMBL	BC115407	http://www.ebi.ac.uk/ena/data/view/BC115407
EMBL	X57303	http://www.ebi.ac.uk/ena/data/view/X57303
EMBL	X59155	http://www.ebi.ac.uk/ena/data/view/X59155
Ensembl	ENST00000380752	http://www.ensembl.org/id/ENST00000380752
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0000064	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000064
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_function	GO:0015181	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015181
GO_function	GO:0015189	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015189
GO_function	GO:0015297	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GO_process	GO:0015809	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015809
GO_process	GO:1903352	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903352
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC7A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC7A1
GeneID	6541	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6541
GeneTree	ENSGT00760000119151	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119151
HGNC	HGNC:11057	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11057
HOGENOM	HOG000250623	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000250623&db=HOGENOM6
HOVERGEN	HBG000280	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000280&db=HOVERGEN
HPA	HPA039721	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA039721
InParanoid	P30825	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30825
IntAct	P30825	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30825*
InterPro	IPR002293	http://www.ebi.ac.uk/interpro/entry/IPR002293
InterPro	IPR004755	http://www.ebi.ac.uk/interpro/entry/IPR004755
InterPro	IPR029485	http://www.ebi.ac.uk/interpro/entry/IPR029485
Jabion	6541	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6541
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6541	http://www.genome.jp/dbget-bin/www_bget?hsa:6541
KEGG_Orthology	KO:K13863	http://www.genome.jp/dbget-bin/www_bget?KO:K13863
MIM	104615	http://www.ncbi.nlm.nih.gov/omim/104615
MINT	MINT-3012079	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3012079
OMA	LAMIICP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LAMIICP
OrthoDB	EOG091G05NM	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05NM
PANTHER	PTHR11785	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785
PSORT	swissprot:CTR1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CTR1_HUMAN
PSORT-B	swissprot:CTR1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CTR1_HUMAN
PSORT2	swissprot:CTR1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CTR1_HUMAN
Pfam	PF13520	http://pfam.xfam.org/family/PF13520
Pfam	PF13906	http://pfam.xfam.org/family/PF13906
PharmGKB	PA35917	http://www.pharmgkb.org/do/serve?objId=PA35917&objCls=Gene
Phobius	swissprot:CTR1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CTR1_HUMAN
PhylomeDB	P30825	http://phylomedb.org/?seqid=P30825
ProteinModelPortal	P30825	http://www.proteinmodelportal.org/query/uniprot/P30825
PubMed	10485994	http://www.ncbi.nlm.nih.gov/pubmed/10485994
PubMed	1348489	http://www.ncbi.nlm.nih.gov/pubmed/1348489
PubMed	15057823	http://www.ncbi.nlm.nih.gov/pubmed/15057823
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	1718082	http://www.ncbi.nlm.nih.gov/pubmed/1718082
PubMed	19349973	http://www.ncbi.nlm.nih.gov/pubmed/19349973
Reactome	R-HSA-352230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-352230
RefSeq	NP_003036	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003036
RefSeq	XP_005266564	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005266564
RefSeq	XP_016876205	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016876205
STRING	9606.ENSP00000370128	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000370128&targetmode=cogs
TCDB	2.A.3.3	http://www.tcdb.org/search/result.php?tc=2.A.3.3
TIGRFAMs	TIGR00906	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00906
UCSC	uc001uso	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001uso&org=rat
UniGene	Hs.14846	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.14846
UniProtKB	CTR1_HUMAN	http://www.uniprot.org/uniprot/CTR1_HUMAN
UniProtKB-AC	P30825	http://www.uniprot.org/uniprot/P30825
charge	swissprot:CTR1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CTR1_HUMAN
eggNOG	COG0531	http://eggnogapi.embl.de/nog_data/html/tree/COG0531
eggNOG	KOG1286	http://eggnogapi.embl.de/nog_data/html/tree/KOG1286
epestfind	swissprot:CTR1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CTR1_HUMAN
garnier	swissprot:CTR1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CTR1_HUMAN
helixturnhelix	swissprot:CTR1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CTR1_HUMAN
hmoment	swissprot:CTR1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CTR1_HUMAN
iep	swissprot:CTR1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CTR1_HUMAN
inforesidue	swissprot:CTR1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CTR1_HUMAN
neXtProt	NX_P30825	http://www.nextprot.org/db/entry/NX_P30825
octanol	swissprot:CTR1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CTR1_HUMAN
pepcoil	swissprot:CTR1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CTR1_HUMAN
pepdigest	swissprot:CTR1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CTR1_HUMAN
pepinfo	swissprot:CTR1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CTR1_HUMAN
pepnet	swissprot:CTR1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CTR1_HUMAN
pepstats	swissprot:CTR1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CTR1_HUMAN
pepwheel	swissprot:CTR1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CTR1_HUMAN
pepwindow	swissprot:CTR1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CTR1_HUMAN
sigcleave	swissprot:CTR1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CTR1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CTSR2_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Variant 2; IsoId=Q96P56-1; Sequence=Displayed; Name=2; Synonyms=Variant 1; IsoId=Q96P56-2; Sequence=VSP_026976; Name=3; Synonyms=Variant 3; IsoId=Q96P56-3; Sequence=VSP_026975, VSP_026977; Name=4; IsoId=Q96P56-4; Sequence=VSP_026973, VSP_026974; Note=No experimental confirmation available.; 
# CCDS	CCDS10099	-. [Q96P56-1]
# CCDS	CCDS32216	-. [Q96P56-2]
# DISEASE	CTSR2_HUMAN	Deafness-infertility syndrome (DIS) [MIM 611102]  Characterized by deafness and infertility and is caused by large contiguous gene deletions at 15q15.3 that removes both STRC and CATSPER2 genes. {ECO 0000269|PubMed 12825070, ECO 0000269|PubMed 17098888}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# ENZYME REGULATION	CTSR2_HUMAN	The CatSper calcium channel is indirectly activated by extracellular progesterone and prostaglandins following the sequence  progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2 (PubMed 21412338, PubMed 21412339, PubMed 26989199). The CatSper calcium channel is directly inhibited by endocannabinoid 2-arachidonoylglycerol (2AG) (PubMed 26989199). Indirect activation by progesterone takes place via the following mechanism  progesterone binds and activates the acylglycerol lipase ABHD2, which in turn mediates hydrolysis of 2AG inhibitor, relieving inhibition of the CatSper channel (PubMed 26989199). The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers (PubMed 21412338, PubMed 21412339). Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH (PubMed 21412338, PubMed 21412339). {ECO 0000269|PubMed 21412338, ECO 0000269|PubMed 21412339, ECO 0000269|PubMed 26989199}. 
# Ensembl	ENST00000321596	ENSP00000321463; ENSG00000166762. [Q96P56-1]
# Ensembl	ENST00000396879	ENSP00000380088; ENSG00000166762. [Q96P56-2]
# Ensembl	ENST00000433380	ENSP00000389746; ENSG00000166762. [Q96P56-3]
# ExpressionAtlas	Q96P56	baseline and differential
# FUNCTION	CTSR2_HUMAN	Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. {ECO 0000269|PubMed 21412338, ECO 0000269|PubMed 21412339}. 
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0031514	motile cilium; IEA:UniProtKB-KW.
# GO_component	GO:0036128	CatSper complex; ISS:UniProtKB.
# GO_function	GO:0005227	calcium activated cation channel activity; IEA:InterPro.
# GO_function	GO:0005245	voltage-gated calcium channel activity; IBA:GO_Central.
# GO_process	GO:0007275	multicellular organism development; IEA:UniProtKB-KW.
# GO_process	GO:0007283	spermatogenesis; IEA:UniProtKB-KW.
# GO_process	GO:0030154	cell differentiation; IEA:UniProtKB-KW.
# GO_process	GO:0030317	flagellated sperm motility; IBA:GO_Central.
# GO_process	GO:0032570	response to progesterone; TAS:Reactome.
# GO_process	GO:0035036	sperm-egg recognition; TAS:Reactome.
# GO_process	GO:0086010	membrane depolarization during action potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0005929	cilium
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0048870	cell motility
# Gene3D	1.20.120.350	-; 1.
# Genevisible	Q96P56	HS
# HGNC	HGNC:18810	CATSPER2
# INTERACTION	CTSR2_HUMAN	Q9P0X4 CACNA1I; NbExp=3; IntAct=EBI-2215024, EBI-1220829; 
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028747	CatSper2
# MIM	607249	gene
# MIM	611102	phenotype
# Organism	CTSR2_HUMAN	Homo sapiens (Human)
# Orphanet	94064	Deafness-infertility syndrome
# PANTHER	PTHR10037:SF189	PTHR10037:SF189
# Pfam	PF00520	Ion_trans
# Proteomes	UP000005640	Chromosome 15
# Reactome	R-HSA-1300642	Sperm Motility And Taxes
# RecName	CTSR2_HUMAN	Cation channel sperm-associated protein 2
# RefSeq	NP_001269238	NM_001282309.1. [Q96P56-2]
# RefSeq	NP_473361	NM_054020.3. [Q96P56-2]
# RefSeq	NP_742093	NM_172095.2. [Q96P56-1]
# RefSeq	XP_016877393	XM_017021904.1. [Q96P56-1]
# SIMILARITY	Belongs to the cation channel sperm-associated (TC 1.A.1.19) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	CTSR2_HUMAN	Cell projection, cilium, flagellum membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Note=Specifically located in the principal piece of sperm tail. 
# SUBUNIT	Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Component of the CatSper complex. Interacts with Ca(v)3.3/CACNA1I, leading to suppress T- type calcium channel activity. {ECO:0000269|PubMed	16740636, ECO:0000305}. 
# TCDB	1.A.1.19	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	CTSR2_HUMAN	Testis-specific. {ECO 0000269|PubMed 11675491, ECO 0000269|PubMed 17347248}. 
# UCSC	uc001zsh	human. [Q96P56-1]
# eggNOG	ENOG410INF6	Eukaryota
# eggNOG	ENOG4111GC6	LUCA
BLAST	swissprot:CTSR2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CTSR2_HUMAN
BioCyc	ZFISH:ENSG00000166762-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000166762-MONOMER
COXPRESdb	117155	http://coxpresdb.jp/data/gene/117155.shtml
CleanEx	HS_CATSPER2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CATSPER2
DOI	10.1038/nature09767	http://dx.doi.org/10.1038/nature09767
DOI	10.1038/nature09769	http://dx.doi.org/10.1038/nature09769
DOI	10.1038/sj.ejhg.5200991	http://dx.doi.org/10.1038/sj.ejhg.5200991
DOI	10.1073/pnas.221454998	http://dx.doi.org/10.1073/pnas.221454998
DOI	10.1074/jbc.M511288200	http://dx.doi.org/10.1074/jbc.M511288200
DOI	10.1093/molehr/gam009	http://dx.doi.org/10.1093/molehr/gam009
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.aad6887	http://dx.doi.org/10.1126/science.aad6887
DOI	10.1136/jmg.2006.045765	http://dx.doi.org/10.1136/jmg.2006.045765
EMBL	AF411817	http://www.ebi.ac.uk/ena/data/view/AF411817
EMBL	AF411818	http://www.ebi.ac.uk/ena/data/view/AF411818
EMBL	AF411819	http://www.ebi.ac.uk/ena/data/view/AF411819
EMBL	BC028728	http://www.ebi.ac.uk/ena/data/view/BC028728
EMBL	BC064387	http://www.ebi.ac.uk/ena/data/view/BC064387
Ensembl	ENST00000321596	http://www.ensembl.org/id/ENST00000321596
Ensembl	ENST00000396879	http://www.ensembl.org/id/ENST00000396879
Ensembl	ENST00000433380	http://www.ensembl.org/id/ENST00000433380
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0031514	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031514
GO_component	GO:0036128	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036128
GO_function	GO:0005227	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005227
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_process	GO:0007275	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007275
GO_process	GO:0007283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007283
GO_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GO_process	GO:0030317	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030317
GO_process	GO:0032570	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032570
GO_process	GO:0035036	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035036
GO_process	GO:0086010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086010
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0005929	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005929
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	CATSPER2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CATSPER2
GeneID	117155	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=117155
GeneTree	ENSGT00760000119325	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119325
HGNC	HGNC:18810	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18810
HOGENOM	HOG000007710	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007710&db=HOGENOM6
HOVERGEN	HBG107782	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG107782&db=HOVERGEN
HPA	HPA042709	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042709
InParanoid	Q96P56	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96P56
IntAct	Q96P56	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96P56*
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028747	http://www.ebi.ac.uk/interpro/entry/IPR028747
Jabion	117155	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=117155
KEGG_Gene	hsa:117155	http://www.genome.jp/dbget-bin/www_bget?hsa:117155
MIM	607249	http://www.ncbi.nlm.nih.gov/omim/607249
MIM	611102	http://www.ncbi.nlm.nih.gov/omim/611102
Orphanet	94064	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=94064
PANTHER	PTHR10037:SF189	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10037:SF189
PSORT	swissprot:CTSR2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CTSR2_HUMAN
PSORT-B	swissprot:CTSR2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CTSR2_HUMAN
PSORT2	swissprot:CTSR2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CTSR2_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
PharmGKB	PA38691	http://www.pharmgkb.org/do/serve?objId=PA38691&objCls=Gene
Phobius	swissprot:CTSR2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CTSR2_HUMAN
PhylomeDB	Q96P56	http://phylomedb.org/?seqid=Q96P56
ProteinModelPortal	Q96P56	http://www.proteinmodelportal.org/query/uniprot/Q96P56
PubMed	11675491	http://www.ncbi.nlm.nih.gov/pubmed/11675491
PubMed	12825070	http://www.ncbi.nlm.nih.gov/pubmed/12825070
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16740636	http://www.ncbi.nlm.nih.gov/pubmed/16740636
PubMed	17098888	http://www.ncbi.nlm.nih.gov/pubmed/17098888
PubMed	17347248	http://www.ncbi.nlm.nih.gov/pubmed/17347248
PubMed	21412338	http://www.ncbi.nlm.nih.gov/pubmed/21412338
PubMed	21412339	http://www.ncbi.nlm.nih.gov/pubmed/21412339
PubMed	26989199	http://www.ncbi.nlm.nih.gov/pubmed/26989199
Reactome	R-HSA-1300642	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1300642
RefSeq	NP_001269238	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269238
RefSeq	NP_473361	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_473361
RefSeq	NP_742093	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_742093
RefSeq	XP_016877393	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016877393
STRING	9606.ENSP00000299989	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000299989&targetmode=cogs
TCDB	1.A.1.19	http://www.tcdb.org/search/result.php?tc=1.A.1.19
UCSC	uc001zsh	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001zsh&org=rat
UniGene	Hs.662284	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.662284
UniProtKB	CTSR2_HUMAN	http://www.uniprot.org/uniprot/CTSR2_HUMAN
UniProtKB-AC	Q96P56	http://www.uniprot.org/uniprot/Q96P56
charge	swissprot:CTSR2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CTSR2_HUMAN
eggNOG	ENOG410INF6	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410INF6
eggNOG	ENOG4111GC6	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111GC6
epestfind	swissprot:CTSR2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CTSR2_HUMAN
garnier	swissprot:CTSR2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CTSR2_HUMAN
helixturnhelix	swissprot:CTSR2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CTSR2_HUMAN
hmoment	swissprot:CTSR2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CTSR2_HUMAN
iep	swissprot:CTSR2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CTSR2_HUMAN
inforesidue	swissprot:CTSR2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CTSR2_HUMAN
neXtProt	NX_Q96P56	http://www.nextprot.org/db/entry/NX_Q96P56
octanol	swissprot:CTSR2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CTSR2_HUMAN
pepcoil	swissprot:CTSR2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CTSR2_HUMAN
pepdigest	swissprot:CTSR2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CTSR2_HUMAN
pepinfo	swissprot:CTSR2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CTSR2_HUMAN
pepnet	swissprot:CTSR2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CTSR2_HUMAN
pepstats	swissprot:CTSR2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CTSR2_HUMAN
pepwheel	swissprot:CTSR2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CTSR2_HUMAN
pepwindow	swissprot:CTSR2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CTSR2_HUMAN
sigcleave	swissprot:CTSR2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CTSR2_HUMAN
## Database	ID	URL or Descriptions
# AltName	MOT13_HUMAN	Solute carrier family 16 member 13
# BioGrid	128373	2
# CDD	cd06174	MFS
# ChiTaRS	SLC16A13	human
# DISEASE	MOT13_HUMAN	Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM 125853]  A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO 0000269|PubMed 24390345}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# Ensembl	ENST00000308027	ENSP00000309751; ENSG00000174327
# FUNCTION	MOT13_HUMAN	Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane. {ECO 0000305|PubMed 12739169}. 
# GO_component	GO:0000139	Golgi membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005794	Golgi apparatus; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0015129	lactate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_process	GO:0035879	plasma membrane lactate transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# HGNC	HGNC:31037	SLC16A13
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	125853	phenotype
# Organism	MOT13_HUMAN	Homo sapiens (Human)
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 17
# RecName	MOT13_HUMAN	Monocarboxylate transporter 13
# RefSeq	NP_963860	NM_201566.2
# SIMILARITY	Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	MOT13_HUMAN	Golgi apparatus membrane {ECO 0000269|PubMed 24390345}; Multi-pass membrane protein {ECO 0000269|PubMed 24390345}. Cell membrane {ECO 0000255}; Multi- pass membrane protein {ECO 0000255}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.13.17	the major facilitator superfamily (mfs)
# UCSC	uc002geh	human
# eggNOG	ENOG410IMVT	Eukaryota
# eggNOG	ENOG4111K3V	LUCA
BLAST	swissprot:MOT13_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MOT13_HUMAN
BioCyc	ZFISH:ENSG00000174327-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000174327-MONOMER
COXPRESdb	201232	http://coxpresdb.jp/data/gene/201232.shtml
CleanEx	HS_SLC16A13	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC16A13
DOI	10.1007/s00424-003-1067-2	http://dx.doi.org/10.1007/s00424-003-1067-2
DOI	10.1038/nature12828	http://dx.doi.org/10.1038/nature12828
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	BC109286	http://www.ebi.ac.uk/ena/data/view/BC109286
EMBL	BC131739	http://www.ebi.ac.uk/ena/data/view/BC131739
EMBL	BC142618	http://www.ebi.ac.uk/ena/data/view/BC142618
EMBL	BN000145	http://www.ebi.ac.uk/ena/data/view/BN000145
EMBL	CH471108	http://www.ebi.ac.uk/ena/data/view/CH471108
Ensembl	ENST00000308027	http://www.ensembl.org/id/ENST00000308027
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0015129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015129
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_process	GO:0035879	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035879
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC16A13	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC16A13
GeneID	201232	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=201232
GeneTree	ENSGT00760000118926	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118926
H-InvDB	HIX0039261	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0039261
HGNC	HGNC:31037	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:31037
HOGENOM	HOG000280688	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280688&db=HOGENOM6
HOVERGEN	HBG106552	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG106552&db=HOVERGEN
HPA	HPA065245	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA065245
InParanoid	Q7RTY0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q7RTY0
IntAct	Q7RTY0	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q7RTY0*
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	201232	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=201232
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:201232	http://www.genome.jp/dbget-bin/www_bget?hsa:201232
KEGG_Orthology	KO:K08189	http://www.genome.jp/dbget-bin/www_bget?KO:K08189
MIM	125853	http://www.ncbi.nlm.nih.gov/omim/125853
OMA	DWDPLSA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DWDPLSA
OrthoDB	EOG091G05SW	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05SW
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:MOT13_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MOT13_HUMAN
PSORT-B	swissprot:MOT13_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MOT13_HUMAN
PSORT2	swissprot:MOT13_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MOT13_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA134991782	http://www.pharmgkb.org/do/serve?objId=PA134991782&objCls=Gene
Phobius	swissprot:MOT13_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MOT13_HUMAN
PhylomeDB	Q7RTY0	http://phylomedb.org/?seqid=Q7RTY0
ProteinModelPortal	Q7RTY0	http://www.proteinmodelportal.org/query/uniprot/Q7RTY0
PubMed	12739169	http://www.ncbi.nlm.nih.gov/pubmed/12739169
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	24390345	http://www.ncbi.nlm.nih.gov/pubmed/24390345
RefSeq	NP_963860	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_963860
STRING	9606.ENSP00000309751	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000309751&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.13.17	http://www.tcdb.org/search/result.php?tc=2.A.1.13.17
UCSC	uc002geh	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002geh&org=rat
UniGene	Hs.448010	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.448010
UniProtKB	MOT13_HUMAN	http://www.uniprot.org/uniprot/MOT13_HUMAN
UniProtKB-AC	Q7RTY0	http://www.uniprot.org/uniprot/Q7RTY0
charge	swissprot:MOT13_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MOT13_HUMAN
eggNOG	ENOG410IMVT	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IMVT
eggNOG	ENOG4111K3V	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111K3V
epestfind	swissprot:MOT13_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MOT13_HUMAN
garnier	swissprot:MOT13_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MOT13_HUMAN
helixturnhelix	swissprot:MOT13_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MOT13_HUMAN
hmoment	swissprot:MOT13_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MOT13_HUMAN
iep	swissprot:MOT13_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MOT13_HUMAN
inforesidue	swissprot:MOT13_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MOT13_HUMAN
neXtProt	NX_Q7RTY0	http://www.nextprot.org/db/entry/NX_Q7RTY0
octanol	swissprot:MOT13_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MOT13_HUMAN
pepcoil	swissprot:MOT13_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MOT13_HUMAN
pepdigest	swissprot:MOT13_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MOT13_HUMAN
pepinfo	swissprot:MOT13_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MOT13_HUMAN
pepnet	swissprot:MOT13_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MOT13_HUMAN
pepstats	swissprot:MOT13_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MOT13_HUMAN
pepwheel	swissprot:MOT13_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MOT13_HUMAN
pepwindow	swissprot:MOT13_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MOT13_HUMAN
sigcleave	swissprot:MOT13_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MOT13_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNKH_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96T54-3; Sequence=Displayed; Name=2; IsoId=Q96T54-4; Sequence=VSP_047354; Note=No experimental confirmation available. Gene prediction based on EST data.; 
# AltName	KCNKH_HUMAN	2P domain potassium channel Talk-2
# AltName	KCNKH_HUMAN	Acid-sensitive potassium channel protein TASK-4
# AltName	KCNKH_HUMAN	TWIK-related acid-sensitive K(+) channel 4
# AltName	KCNKH_HUMAN	TWIK-related alkaline pH-activated K(+) channel 2
# CCDS	CCDS47419	-. [Q96T54-4]
# CCDS	CCDS4842	-. [Q96T54-3]
# Ensembl	ENST00000373231	ENSP00000362328; ENSG00000124780. [Q96T54-3]
# Ensembl	ENST00000453413	ENSP00000401271; ENSG00000124780. [Q96T54-4]
# FUNCTION	KCNKH_HUMAN	Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0005244	voltage-gated ion channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0005267	potassium channel activity; IDA:UniProtKB.
# GO_function	GO:0022841	potassium ion leak channel activity; IBA:GO_Central.
# GO_process	GO:0006813	potassium ion transport; IDA:UniProtKB.
# GO_process	GO:0030322	stabilization of membrane potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q96T54	HS
# HGNC	HGNC:14465	KCNK17
# InterPro	IPR003092	2pore_dom_K_chnl_TASK
# InterPro	IPR003280	2pore_dom_K_chnl
# InterPro	IPR013099	K_chnl_dom
# KEGG_Brite	ko04040	Ion channels
# MIM	607370	gene
# MISCELLANEOUS	KCNKH_HUMAN	Inhibited by Ba(2+), quinidine, chloroform and halothane. Activated at alkaline pH. Activated by quinine and isoflurane. 
# Organism	KCNKH_HUMAN	Homo sapiens (Human)
# PIRSF	PIRSF038061	K_channel_subfamily_K_type
# PRINTS	PR01095	TASKCHANNEL
# PRINTS	PR01333	2POREKCHANEL
# Pfam	PF07885	Ion_trans_2; 2
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-1299361	TWIK-related alkaline pH activated K+ channel (TALK)
# Reactome	R-HSA-5576886	Phase 4 - resting membrane potential
# RecName	KCNKH_HUMAN	Potassium channel subfamily K member 17
# RefSeq	NP_001128583	NM_001135111.1. [Q96T54-4]
# RefSeq	NP_113648	NM_031460.3. [Q96T54-3]
# SEQUENCE CAUTION	Sequence=AAK28551.1; Type=Frameshift; Positions=260; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	KCNKH_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Homodimer. {ECO	0000305}. 
# TCDB	1.A.1.9	the voltage-gated ion channel (vic) superfamily
# UCSC	uc003ooo	human. [Q96T54-3]
# eggNOG	COG1226	LUCA
# eggNOG	KOG1418	Eukaryota
BLAST	swissprot:KCNKH_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNKH_HUMAN
BioCyc	ZFISH:ENSG00000124780-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000124780-MONOMER
COXPRESdb	89822	http://coxpresdb.jp/data/gene/89822.shtml
CleanEx	HS_KCNK17	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNK17
DOI	10.1006/bbrc.2001.4562	http://dx.doi.org/10.1006/bbrc.2001.4562
DOI	10.1016/S0014-5793(01)02222-0	http://dx.doi.org/10.1016/S0014-5793(01)02222-0
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF339912	http://www.ebi.ac.uk/ena/data/view/AF339912
EMBL	AF358910	http://www.ebi.ac.uk/ena/data/view/AF358910
EMBL	AL136087	http://www.ebi.ac.uk/ena/data/view/AL136087
EMBL	AY358853	http://www.ebi.ac.uk/ena/data/view/AY358853
EMBL	BC025726	http://www.ebi.ac.uk/ena/data/view/BC025726
Ensembl	ENST00000373231	http://www.ensembl.org/id/ENST00000373231
Ensembl	ENST00000453413	http://www.ensembl.org/id/ENST00000453413
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005244
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_function	GO:0022841	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022841
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0030322	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030322
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	KCNK17	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNK17
GeneID	89822	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=89822
GeneTree	ENSGT00760000118858	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118858
HGNC	HGNC:14465	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14465
HOGENOM	HOG000074161	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000074161&db=HOGENOM6
HOVERGEN	HBG052240	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052240&db=HOVERGEN
HPA	HPA043892	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA043892
InParanoid	Q96T54	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96T54
InterPro	IPR003092	http://www.ebi.ac.uk/interpro/entry/IPR003092
InterPro	IPR003280	http://www.ebi.ac.uk/interpro/entry/IPR003280
InterPro	IPR013099	http://www.ebi.ac.uk/interpro/entry/IPR013099
Jabion	89822	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=89822
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:89822	http://www.genome.jp/dbget-bin/www_bget?hsa:89822
KEGG_Orthology	KO:K04925	http://www.genome.jp/dbget-bin/www_bget?KO:K04925
MIM	607370	http://www.ncbi.nlm.nih.gov/omim/607370
OMA	SMGRWEF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SMGRWEF
OrthoDB	EOG091G08DF	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08DF
PRINTS	PR01095	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01095
PRINTS	PR01333	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01333
PSORT	swissprot:KCNKH_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNKH_HUMAN
PSORT-B	swissprot:KCNKH_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNKH_HUMAN
PSORT2	swissprot:KCNKH_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNKH_HUMAN
Pfam	PF07885	http://pfam.xfam.org/family/PF07885
PharmGKB	PA30058	http://www.pharmgkb.org/do/serve?objId=PA30058&objCls=Gene
Phobius	swissprot:KCNKH_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNKH_HUMAN
PhylomeDB	Q96T54	http://phylomedb.org/?seqid=Q96T54
ProteinModelPortal	Q96T54	http://www.proteinmodelportal.org/query/uniprot/Q96T54
PubMed	11248242	http://www.ncbi.nlm.nih.gov/pubmed/11248242
PubMed	11263999	http://www.ncbi.nlm.nih.gov/pubmed/11263999
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-1299361	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1299361
Reactome	R-HSA-5576886	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576886
RefSeq	NP_001128583	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001128583
RefSeq	NP_113648	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_113648
SMR	Q96T54	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q96T54
STRING	9606.ENSP00000362328	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000362328&targetmode=cogs
TCDB	1.A.1.9	http://www.tcdb.org/search/result.php?tc=1.A.1.9
UCSC	uc003ooo	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ooo&org=rat
UniGene	Hs.162282	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.162282
UniProtKB	KCNKH_HUMAN	http://www.uniprot.org/uniprot/KCNKH_HUMAN
UniProtKB-AC	Q96T54	http://www.uniprot.org/uniprot/Q96T54
charge	swissprot:KCNKH_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNKH_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG1418	http://eggnogapi.embl.de/nog_data/html/tree/KOG1418
epestfind	swissprot:KCNKH_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNKH_HUMAN
garnier	swissprot:KCNKH_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNKH_HUMAN
helixturnhelix	swissprot:KCNKH_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNKH_HUMAN
hmoment	swissprot:KCNKH_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNKH_HUMAN
iep	swissprot:KCNKH_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNKH_HUMAN
inforesidue	swissprot:KCNKH_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNKH_HUMAN
neXtProt	NX_Q96T54	http://www.nextprot.org/db/entry/NX_Q96T54
octanol	swissprot:KCNKH_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNKH_HUMAN
pepcoil	swissprot:KCNKH_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNKH_HUMAN
pepdigest	swissprot:KCNKH_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNKH_HUMAN
pepinfo	swissprot:KCNKH_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNKH_HUMAN
pepnet	swissprot:KCNKH_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNKH_HUMAN
pepstats	swissprot:KCNKH_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNKH_HUMAN
pepwheel	swissprot:KCNKH_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNKH_HUMAN
pepwindow	swissprot:KCNKH_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNKH_HUMAN
sigcleave	swissprot:KCNKH_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNKH_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	EAA1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P43003-1; Sequence=Displayed; Name=2; Synonyms=EAAT1ex9skip; IsoId=P43003-2; Sequence=VSP_043913; Note=Expressed throughout the CNS, both in gray matter and axonal tracts, at levels ranging between 10% and 20% of isoform 1. Localizes to ER, has no functional glutamate uptake activity, and exerts a dominant negative effect isoform 1.; 
# AltName	EAA1_HUMAN	Sodium-dependent glutamate/aspartate transporter 1
# AltName	EAA1_HUMAN	Solute carrier family 1 member 3
# BioGrid	112398	7
# CCDS	CCDS3919	-. [P43003-1]
# CCDS	CCDS54844	-. [P43003-2]
# ChiTaRS	SLC1A3	human
# DISEASE	EAA1_HUMAN	Episodic ataxia 6 (EA6) [MIM 612656]  A disorder characterized by episodic ataxia, seizures, migraine and alternating hemiplegia. {ECO 0000269|PubMed 16116111}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000265113	ENSP00000265113; ENSG00000079215. [P43003-1]
# Ensembl	ENST00000381918	ENSP00000371343; ENSG00000079215. [P43003-2]
# ExpressionAtlas	P43003	baseline and differential
# FUNCTION	EAA1_HUMAN	Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0009986	cell surface; IEA:Ensembl.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0043005	neuron projection; IEA:Ensembl.
# GO_component	GO:0043025	neuronal cell body; IEA:Ensembl.
# GO_component	GO:0043205	fibril; IEA:Ensembl.
# GO_function	GO:0005313	L-glutamate transmembrane transporter activity; IDA:BHF-UCL.
# GO_function	GO:0005314	high-affinity glutamate transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0016595	glutamate binding; IEA:Ensembl.
# GO_function	GO:0016597	amino acid binding; IEA:Ensembl.
# GO_process	GO:0001504	neurotransmitter uptake; TAS:ProtInc.
# GO_process	GO:0006537	glutamate biosynthetic process; IEA:Ensembl.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:ProtInc.
# GO_process	GO:0007605	sensory perception of sound; IEA:Ensembl.
# GO_process	GO:0009416	response to light stimulus; IEA:Ensembl.
# GO_process	GO:0009449	gamma-aminobutyric acid biosynthetic process; IEA:Ensembl.
# GO_process	GO:0009611	response to wounding; IEA:Ensembl.
# GO_process	GO:0014047	glutamate secretion; TAS:Reactome.
# GO_process	GO:0021545	cranial nerve development; IEA:Ensembl.
# GO_process	GO:0031223	auditory behavior; IEA:Ensembl.
# GO_process	GO:0042493	response to drug; IEA:Ensembl.
# GO_process	GO:0046677	response to antibiotic; IEA:Ensembl.
# GO_process	GO:0048667	cell morphogenesis involved in neuron differentiation; IEA:Ensembl.
# GO_process	GO:0050806	positive regulation of synaptic transmission; IEA:Ensembl.
# GO_process	GO:0050885	neuromuscular process controlling balance; IEA:Ensembl.
# GO_process	GO:0051938	L-glutamate import; IDA:UniProtKB.
# GO_process	GO:0070779	D-aspartate import; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0000902	cell morphogenesis
# GOslim_process	GO:0006520	cellular amino acid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# Gene3D	1.10.3860.10	-; 2.
# Genevisible	P43003	HS
# HGNC	HGNC:10941	SLC1A3
# IntAct	P43003	3
# InterPro	IPR001991	Na-dicarboxylate_symporter
# InterPro	IPR018107	Na-dicarboxylate_symporter_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H00749	[Nervous system disease] Episodic ataxias
# KEGG_Pathway	ko04724	Glutamatergic synapse
# MIM	600111	gene
# MIM	612656	phenotype
# Organism	EAA1_HUMAN	Homo sapiens (Human)
# Orphanet	209967	Episodic ataxia type 6
# Orphanet	2131	Alternating hemiplegia of childhood
# PANTHER	PTHR11958	PTHR11958; 2
# PIR	S38353	S38353
# PRINTS	PR00173	EDTRNSPORT
# PROSITE	PS00713	NA_DICARBOXYL_SYMP_1
# PROSITE	PS00714	NA_DICARBOXYL_SYMP_2
# PTM	EAA1_HUMAN	Glycosylated. 
# Pfam	PF00375	SDF
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-210455	Astrocytic Glutamate-Glutamine Uptake And Metabolism
# Reactome	R-HSA-210500	Glutamate Neurotransmitter Release Cycle
# Reactome	R-HSA-425393	Transport of inorganic cations/anions and amino acids/oligopeptides
# RecName	EAA1_HUMAN	Excitatory amino acid transporter 1
# RefSeq	NP_001160167	NM_001166695.2. [P43003-2]
# RefSeq	NP_001276869	NM_001289940.1
# RefSeq	NP_004163	NM_004172.4. [P43003-1]
# RefSeq	XP_005248399	XM_005248342.2. [P43003-1]
# SIMILARITY	Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A3 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	EAA1_HUMAN	Membrane; Multi-pass membrane protein. 
# SUPFAM	SSF118215	SSF118215; 2
# TCDB	2.A.23.2:the dicarboxylate/amino acid	cation (na(+) or h(+)) symporter (daacs) family
# TISSUE SPECIFICITY	EAA1_HUMAN	Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia. 
# UCSC	uc003jkj	human. [P43003-1]
# eggNOG	COG1301	LUCA
# eggNOG	KOG3787	Eukaryota
BLAST	swissprot:EAA1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:EAA1_HUMAN
BioCyc	ZFISH:ENSG00000079215-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000079215-MONOMER
COXPRESdb	6507	http://coxpresdb.jp/data/gene/6507.shtml
CleanEx	HS_SLC1A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC1A3
DOI	10.1006/bbrc.1994.1210	http://dx.doi.org/10.1006/bbrc.1994.1210
DOI	10.1016/0014-5793(96)00424-3	http://dx.doi.org/10.1016/0014-5793(96)00424-3
DOI	10.1016/0167-4781(93)90057-K	http://dx.doi.org/10.1016/0167-4781(93)90057-K
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1111/j.1471-4159.2005.03370.x	http://dx.doi.org/10.1111/j.1471-4159.2005.03370.x
DOI	10.1212/01.WNL.0000172638.58172.5a	http://dx.doi.org/10.1212/01.WNL.0000172638.58172.5a
EMBL	AC008957	http://www.ebi.ac.uk/ena/data/view/AC008957
EMBL	AC010631	http://www.ebi.ac.uk/ena/data/view/AC010631
EMBL	AK312304	http://www.ebi.ac.uk/ena/data/view/AK312304
EMBL	AY954110	http://www.ebi.ac.uk/ena/data/view/AY954110
EMBL	CH471119	http://www.ebi.ac.uk/ena/data/view/CH471119
EMBL	D26443	http://www.ebi.ac.uk/ena/data/view/D26443
EMBL	L19158	http://www.ebi.ac.uk/ena/data/view/L19158
EMBL	U03504	http://www.ebi.ac.uk/ena/data/view/U03504
EMBL	Z31703	http://www.ebi.ac.uk/ena/data/view/Z31703
EMBL	Z31704	http://www.ebi.ac.uk/ena/data/view/Z31704
EMBL	Z31705	http://www.ebi.ac.uk/ena/data/view/Z31705
EMBL	Z31706	http://www.ebi.ac.uk/ena/data/view/Z31706
EMBL	Z31707	http://www.ebi.ac.uk/ena/data/view/Z31707
EMBL	Z31708	http://www.ebi.ac.uk/ena/data/view/Z31708
EMBL	Z31709	http://www.ebi.ac.uk/ena/data/view/Z31709
EMBL	Z31710	http://www.ebi.ac.uk/ena/data/view/Z31710
EMBL	Z31713	http://www.ebi.ac.uk/ena/data/view/Z31713
Ensembl	ENST00000265113	http://www.ensembl.org/id/ENST00000265113
Ensembl	ENST00000381918	http://www.ensembl.org/id/ENST00000381918
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0043005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043005
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0043205	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043205
GO_function	GO:0005313	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005313
GO_function	GO:0005314	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005314
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_function	GO:0016595	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016595
GO_function	GO:0016597	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016597
GO_process	GO:0001504	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001504
GO_process	GO:0006537	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006537
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007605
GO_process	GO:0009416	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009416
GO_process	GO:0009449	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009449
GO_process	GO:0009611	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009611
GO_process	GO:0014047	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014047
GO_process	GO:0021545	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021545
GO_process	GO:0031223	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031223
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0046677	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677
GO_process	GO:0048667	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048667
GO_process	GO:0050806	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050806
GO_process	GO:0050885	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050885
GO_process	GO:0051938	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051938
GO_process	GO:0070779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070779
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0000902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000902
GOslim_process	GO:0006520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
Gene3D	1.10.3860.10	http://www.cathdb.info/version/latest/superfamily/1.10.3860.10
GeneCards	SLC1A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC1A3
GeneID	6507	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6507
GeneTree	ENSGT00760000119117	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119117
HGNC	HGNC:10941	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10941
HOGENOM	HOG000208776	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000208776&db=HOGENOM6
HOVERGEN	HBG000080	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000080&db=HOVERGEN
HPA	CAB002573	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB002573
HPA	HPA037467	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA037467
HPA	HPA037468	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA037468
InParanoid	P43003	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P43003
IntAct	P43003	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P43003*
InterPro	IPR001991	http://www.ebi.ac.uk/interpro/entry/IPR001991
InterPro	IPR018107	http://www.ebi.ac.uk/interpro/entry/IPR018107
Jabion	6507	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6507
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00749	http://www.genome.jp/dbget-bin/www_bget?H00749
KEGG_Gene	hsa:6507	http://www.genome.jp/dbget-bin/www_bget?hsa:6507
KEGG_Orthology	KO:K05614	http://www.genome.jp/dbget-bin/www_bget?KO:K05614
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
MIM	600111	http://www.ncbi.nlm.nih.gov/omim/600111
MIM	612656	http://www.ncbi.nlm.nih.gov/omim/612656
MINT	MINT-5004226	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5004226
OMA	FKTSYEK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FKTSYEK
Orphanet	209967	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=209967
Orphanet	2131	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=2131
OrthoDB	EOG091G0UCE	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0UCE
PANTHER	PTHR11958	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11958
PRINTS	PR00173	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00173
PROSITE	PS00713	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00713
PROSITE	PS00714	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00714
PSORT	swissprot:EAA1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:EAA1_HUMAN
PSORT-B	swissprot:EAA1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:EAA1_HUMAN
PSORT2	swissprot:EAA1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:EAA1_HUMAN
Pfam	PF00375	http://pfam.xfam.org/family/PF00375
PharmGKB	PA35828	http://www.pharmgkb.org/do/serve?objId=PA35828&objCls=Gene
Phobius	swissprot:EAA1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:EAA1_HUMAN
PhylomeDB	P43003	http://phylomedb.org/?seqid=P43003
ProteinModelPortal	P43003	http://www.proteinmodelportal.org/query/uniprot/P43003
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	16042756	http://www.ncbi.nlm.nih.gov/pubmed/16042756
PubMed	16116111	http://www.ncbi.nlm.nih.gov/pubmed/16116111
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	7521911	http://www.ncbi.nlm.nih.gov/pubmed/7521911
PubMed	8123008	http://www.ncbi.nlm.nih.gov/pubmed/8123008
PubMed	8218410	http://www.ncbi.nlm.nih.gov/pubmed/8218410
PubMed	8647279	http://www.ncbi.nlm.nih.gov/pubmed/8647279
Reactome	R-HSA-210455	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-210455
Reactome	R-HSA-210500	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-210500
Reactome	R-HSA-425393	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425393
RefSeq	NP_001160167	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001160167
RefSeq	NP_001276869	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001276869
RefSeq	NP_004163	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004163
RefSeq	XP_005248399	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005248399
STRING	9606.ENSP00000265113	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000265113&targetmode=cogs
SUPFAM	SSF118215	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF118215
TCDB	2.A.23.2	http://www.tcdb.org/search/result.php?tc=2.A.23.2
UCSC	uc003jkj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003jkj&org=rat
UniGene	Hs.481918	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.481918
UniProtKB	EAA1_HUMAN	http://www.uniprot.org/uniprot/EAA1_HUMAN
UniProtKB-AC	P43003	http://www.uniprot.org/uniprot/P43003
charge	swissprot:EAA1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:EAA1_HUMAN
eggNOG	COG1301	http://eggnogapi.embl.de/nog_data/html/tree/COG1301
eggNOG	KOG3787	http://eggnogapi.embl.de/nog_data/html/tree/KOG3787
epestfind	swissprot:EAA1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:EAA1_HUMAN
garnier	swissprot:EAA1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:EAA1_HUMAN
helixturnhelix	swissprot:EAA1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:EAA1_HUMAN
hmoment	swissprot:EAA1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:EAA1_HUMAN
iep	swissprot:EAA1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:EAA1_HUMAN
inforesidue	swissprot:EAA1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:EAA1_HUMAN
neXtProt	NX_P43003	http://www.nextprot.org/db/entry/NX_P43003
octanol	swissprot:EAA1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:EAA1_HUMAN
pepcoil	swissprot:EAA1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:EAA1_HUMAN
pepdigest	swissprot:EAA1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:EAA1_HUMAN
pepinfo	swissprot:EAA1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:EAA1_HUMAN
pepnet	swissprot:EAA1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:EAA1_HUMAN
pepstats	swissprot:EAA1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:EAA1_HUMAN
pepwheel	swissprot:EAA1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:EAA1_HUMAN
pepwindow	swissprot:EAA1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:EAA1_HUMAN
sigcleave	swissprot:EAA1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:EAA1_HUMAN
## Database	ID	URL or Descriptions
# AltName	VPP4_HUMAN	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4
# AltName	VPP4_HUMAN	Vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform
# ChiTaRS	ATP6V0A4	human
# DISEASE	VPP4_HUMAN	Renal tubular acidosis, distal, autosomal recessive (RTADR) [MIM 602722]  An autosomal recessive disease characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis. It is due to functional failure of alpha- intercalated cells of the cortical collecting duct of the distal nephron, where vectorial proton transport is required for urinary acidification. {ECO 0000269|PubMed 10973252, ECO 0000269|PubMed 12414817}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000310018	ENSP00000308122; ENSG00000105929
# Ensembl	ENST00000353492	ENSP00000253856; ENSG00000105929
# Ensembl	ENST00000393054	ENSP00000376774; ENSG00000105929
# ExpressionAtlas	Q9HBG4	baseline and differential
# FUNCTION	VPP4_HUMAN	Part of the proton channel of the V-ATPase that is involved in normal vectorial acid transport into the urine by the kidney. {ECO 0000250}. 
# GO_component	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005768	endosome; ISS:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0010008	endosome membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_component	GO:0030670	phagocytic vesicle membrane; TAS:Reactome.
# GO_component	GO:0031526	brush border membrane; IDA:HGNC.
# GO_component	GO:0045177	apical part of cell; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
# GO_function	GO:0051117	ATPase binding; IPI:UniProtKB.
# GO_process	GO:0001503	ossification; IMP:HGNC.
# GO_process	GO:0006885	regulation of pH; IMP:HGNC.
# GO_process	GO:0007035	vacuolar acidification; IBA:GO_Central.
# GO_process	GO:0007588	excretion; IMP:HGNC.
# GO_process	GO:0007605	sensory perception of sound; IMP:HGNC.
# GO_process	GO:0008286	insulin receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0015986	ATP synthesis coupled proton transport; IBA:GO_Central.
# GO_process	GO:0015991	ATP hydrolysis coupled proton transport; IEA:Ensembl.
# GO_process	GO:0015992	proton transport; IMP:HGNC.
# GO_process	GO:0033572	transferrin transport; TAS:Reactome.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
# GO_process	GO:0090383	phagosome acidification; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9HBG4	HS
# HGNC	HGNC:866	ATP6V0A4
# InterPro	IPR002490	V-ATPase_116kDa_su
# InterPro	IPR026028	V-type_ATPase_116kDa_su_euka
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Disease	H00428	[Urinary system disease] Distal renal tubular acidosis (RTA type 1)
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04142	Lysosome
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04966	Collecting duct acid secretion
# KEGG_Pathway	ko05110	Vibrio cholerae infection
# KEGG_Pathway	ko05120	Epithelial cell signaling in Helicobacter pylori infection
# KEGG_Pathway	ko05152	Tuberculosis
# KEGG_Pathway	ko05323	Rheumatoid arthritis
# MIM	602722	phenotype
# MIM	605239	gene
# Organism	VPP4_HUMAN	Homo sapiens (Human)
# Orphanet	402041	Autosomal recessive distal renal tubular acidosis
# PANTHER	PTHR11629	PTHR11629
# PIRSF	PIRSF001293	ATP6V0A1
# Pfam	PF01496	V_ATPase_I
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-1222556	ROS, RNS production in response to bacteria
# Reactome	R-HSA-77387	Insulin receptor recycling
# Reactome	R-HSA-917977	Transferrin endocytosis and recycling
# Reactome	R-HSA-983712	Ion channel transport
# RecName	VPP4_HUMAN	V-type proton ATPase 116 kDa subunit a isoform 4
# RefSeq	NP_065683	NM_020632.2
# RefSeq	NP_570855	NM_130840.2
# RefSeq	NP_570856	NM_130841.2
# RefSeq	XP_005250450	XM_005250393.1
# RefSeq	XP_005250451	XM_005250394.3
# SIMILARITY	Belongs to the V-ATPase 116 kDa subunit family. {ECO	0000305}.
# SUBCELLULAR LOCATION	VPP4_HUMAN	Apical cell membrane; Multi-pass membrane protein. Note=Present at high density almost exclusively on the apical surface of alpha-intercalated cells in the cortical collecting ducts of the distal nephron. 
# SUBUNIT	VPP4_HUMAN	The V-ATPase is a heteromultimeric enzyme composed of at least thirteen different subunits. It has a membrane peripheral V1 sector for ATP hydrolysis and an integral V0 for proton translocation. The V1 sector comprises subunits A-H, whereas V0 includes subunits a, d, c, c', and c''. 
# TCDB	3.A.2.2	the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily
# TISSUE SPECIFICITY	Expressed in adult and fetal kidney. Found in the inner ear. {ECO:0000269|PubMed	12414817}. 
# UCSC	uc003vuf	human
# eggNOG	COG1269	LUCA
# eggNOG	KOG2189	Eukaryota
BLAST	swissprot:VPP4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VPP4_HUMAN
BioCyc	MetaCyc:ENSG00000105929-MONOMER	http://biocyc.org/getid?id=MetaCyc:ENSG00000105929-MONOMER
BioCyc	ZFISH:ENSG00000105929-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000105929-MONOMER
COG	COG1269	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1269
COXPRESdb	50617	http://coxpresdb.jp/data/gene/50617.shtml
CleanEx	HS_ATP6V0A4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP6V0A4
DOI	10.1038/79208	http://dx.doi.org/10.1038/79208
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1083423	http://dx.doi.org/10.1126/science.1083423
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1136/jmg.39.11.796	http://dx.doi.org/10.1136/jmg.39.11.796
EMBL	AC018663	http://www.ebi.ac.uk/ena/data/view/AC018663
EMBL	AC020983	http://www.ebi.ac.uk/ena/data/view/AC020983
EMBL	AF245517	http://www.ebi.ac.uk/ena/data/view/AF245517
EMBL	AK292945	http://www.ebi.ac.uk/ena/data/view/AK292945
EMBL	BC109304	http://www.ebi.ac.uk/ena/data/view/BC109304
EMBL	BC109305	http://www.ebi.ac.uk/ena/data/view/BC109305
EMBL	CH236950	http://www.ebi.ac.uk/ena/data/view/CH236950
EMBL	CH471070	http://www.ebi.ac.uk/ena/data/view/CH471070
Ensembl	ENST00000310018	http://www.ensembl.org/id/ENST00000310018
Ensembl	ENST00000353492	http://www.ensembl.org/id/ENST00000353492
Ensembl	ENST00000393054	http://www.ensembl.org/id/ENST00000393054
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000220
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0010008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010008
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0030670	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030670
GO_component	GO:0031526	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031526
GO_component	GO:0045177	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045177
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0046961	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046961
GO_function	GO:0051117	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051117
GO_process	GO:0001503	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001503
GO_process	GO:0006885	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006885
GO_process	GO:0007035	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007035
GO_process	GO:0007588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007588
GO_process	GO:0007605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007605
GO_process	GO:0008286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008286
GO_process	GO:0015986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015986
GO_process	GO:0015991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015991
GO_process	GO:0015992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992
GO_process	GO:0033572	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033572
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0070072	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070072
GO_process	GO:0090383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090383
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ATP6V0A4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP6V0A4
GeneID	50617	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=50617
GeneTree	ENSGT00390000004941	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000004941
H-InvDB	HIX0007123	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0007123
HGNC	HGNC:866	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:866
HOGENOM	HOG000037059	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000037059&db=HOGENOM6
HOVERGEN	HBG014606	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG014606&db=HOVERGEN
HPA	HPA018029	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA018029
HPA	HPA064555	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA064555
InParanoid	Q9HBG4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9HBG4
InterPro	IPR002490	http://www.ebi.ac.uk/interpro/entry/IPR002490
InterPro	IPR026028	http://www.ebi.ac.uk/interpro/entry/IPR026028
Jabion	50617	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=50617
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Disease	H00428	http://www.genome.jp/dbget-bin/www_bget?H00428
KEGG_Gene	hsa:50617	http://www.genome.jp/dbget-bin/www_bget?hsa:50617
KEGG_Orthology	KO:K02154	http://www.genome.jp/dbget-bin/www_bget?KO:K02154
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04142	http://www.genome.jp/kegg-bin/show_pathway?ko04142
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04966	http://www.genome.jp/kegg-bin/show_pathway?ko04966
KEGG_Pathway	ko05110	http://www.genome.jp/kegg-bin/show_pathway?ko05110
KEGG_Pathway	ko05120	http://www.genome.jp/kegg-bin/show_pathway?ko05120
KEGG_Pathway	ko05152	http://www.genome.jp/kegg-bin/show_pathway?ko05152
KEGG_Pathway	ko05323	http://www.genome.jp/kegg-bin/show_pathway?ko05323
MIM	602722	http://www.ncbi.nlm.nih.gov/omim/602722
MIM	605239	http://www.ncbi.nlm.nih.gov/omim/605239
OMA	WTMVMNS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WTMVMNS
Orphanet	402041	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=402041
OrthoDB	EOG091G01BI	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01BI
PANTHER	PTHR11629	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11629
PSORT	swissprot:VPP4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VPP4_HUMAN
PSORT-B	swissprot:VPP4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VPP4_HUMAN
PSORT2	swissprot:VPP4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VPP4_HUMAN
Pfam	PF01496	http://pfam.xfam.org/family/PF01496
PharmGKB	PA25147	http://www.pharmgkb.org/do/serve?objId=PA25147&objCls=Gene
Phobius	swissprot:VPP4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VPP4_HUMAN
PhylomeDB	Q9HBG4	http://phylomedb.org/?seqid=Q9HBG4
ProteinModelPortal	Q9HBG4	http://www.proteinmodelportal.org/query/uniprot/Q9HBG4
PubMed	10973252	http://www.ncbi.nlm.nih.gov/pubmed/10973252
PubMed	12414817	http://www.ncbi.nlm.nih.gov/pubmed/12414817
PubMed	12690205	http://www.ncbi.nlm.nih.gov/pubmed/12690205
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
Reactome	R-HSA-1222556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1222556
Reactome	R-HSA-77387	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-77387
Reactome	R-HSA-917977	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917977
Reactome	R-HSA-983712	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983712
RefSeq	NP_065683	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_065683
RefSeq	NP_570855	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_570855
RefSeq	NP_570856	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_570856
RefSeq	XP_005250450	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005250450
RefSeq	XP_005250451	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005250451
STRING	9606.ENSP00000253856	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000253856&targetmode=cogs
STRING	COG1269	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1269&targetmode=cogs
TCDB	3.A.2.2	http://www.tcdb.org/search/result.php?tc=3.A.2.2
UCSC	uc003vuf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003vuf&org=rat
UniGene	Hs.98967	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.98967
UniProtKB	VPP4_HUMAN	http://www.uniprot.org/uniprot/VPP4_HUMAN
UniProtKB-AC	Q9HBG4	http://www.uniprot.org/uniprot/Q9HBG4
charge	swissprot:VPP4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VPP4_HUMAN
eggNOG	COG1269	http://eggnogapi.embl.de/nog_data/html/tree/COG1269
eggNOG	KOG2189	http://eggnogapi.embl.de/nog_data/html/tree/KOG2189
epestfind	swissprot:VPP4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VPP4_HUMAN
garnier	swissprot:VPP4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VPP4_HUMAN
helixturnhelix	swissprot:VPP4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VPP4_HUMAN
hmoment	swissprot:VPP4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VPP4_HUMAN
iep	swissprot:VPP4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VPP4_HUMAN
inforesidue	swissprot:VPP4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VPP4_HUMAN
neXtProt	NX_Q9HBG4	http://www.nextprot.org/db/entry/NX_Q9HBG4
octanol	swissprot:VPP4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VPP4_HUMAN
pepcoil	swissprot:VPP4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VPP4_HUMAN
pepdigest	swissprot:VPP4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VPP4_HUMAN
pepinfo	swissprot:VPP4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VPP4_HUMAN
pepnet	swissprot:VPP4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VPP4_HUMAN
pepstats	swissprot:VPP4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VPP4_HUMAN
pepwheel	swissprot:VPP4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VPP4_HUMAN
pepwindow	swissprot:VPP4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VPP4_HUMAN
sigcleave	swissprot:VPP4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VPP4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GRIK1_HUMAN	Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=GluR5-1D; IsoId=P39086-1; Sequence=Displayed; Name=2; Synonyms=EAA3A; IsoId=P39086-2; Sequence=VSP_000127, VSP_000128; 
# AltName	GRIK1_HUMAN	Excitatory amino acid receptor 3
# AltName	GRIK1_HUMAN	Glutamate receptor 5
# BioGrid	109154	4
# CCDS	CCDS33530	-. [P39086-2]
# CCDS	CCDS42913	-. [P39086-1]
# ChiTaRS	GRIK1	human
# DrugBank	DB00273	Topiramate
# Ensembl	ENST00000389125	ENSP00000373777; ENSG00000171189. [P39086-2]
# Ensembl	ENST00000399907	ENSP00000382791; ENSG00000171189. [P39086-1]
# ExpressionAtlas	P39086	baseline and differential
# FUNCTION	GRIK1_HUMAN	Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0005234	extracellular-glutamate-gated ion channel activity; IEA:InterPro.
# GO_function	GO:0015276	ligand-gated ion channel activity; TAS:Reactome.
# GO_function	GO:0015277	kainate selective glutamate receptor activity; IDA:UniProtKB.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007215	glutamate receptor signaling pathway; TAS:ProtInc.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:ProtInc.
# GO_process	GO:0007399	nervous system development; TAS:ProtInc.
# GO_process	GO:0007417	central nervous system development; TAS:ProtInc.
# GO_process	GO:0051966	regulation of synaptic transmission, glutamatergic; TAS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# Genevisible	P39086	HS
# HGNC	HGNC:4579	GRIK1
# InterPro	IPR001320	Iontro_rcpt
# InterPro	IPR001508	Iono_rcpt_met
# InterPro	IPR001828	ANF_lig-bd_rcpt
# InterPro	IPR019594	Glu/Gly-bd
# InterPro	IPR028082	Peripla_BP_I
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04724	Glutamatergic synapse
# MIM	138245	gene
# MISCELLANEOUS	GRIK1_HUMAN	The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate > L-glutamate = quisqualate > CNQX = DNQX > AMPA > dihydrokainate > NMDA. 
# Organism	GRIK1_HUMAN	Homo sapiens (Human)
# PDB	2ZNS	X-ray; 2.00 A; A=445-559, A=682-820
# PDB	2ZNT	X-ray; 1.60 A; A=445-559, A=682-820
# PDB	2ZNU	X-ray; 1.80 A; A=445-559, A=682-820
# PDB	3FUZ	X-ray; 1.65 A; A/B=445-559, A/B=682-820
# PDB	3FV1	X-ray; 1.50 A; A/B=445-559, A/B=682-820
# PDB	3FV2	X-ray; 1.50 A; A/B=445-559, A/B=682-820
# PDB	3FVG	X-ray; 1.50 A; A/B=445-559, A/B=682-820
# PDB	3FVK	X-ray; 1.50 A; A/B=445-559, A/B=682-820
# PDB	3FVN	X-ray; 1.50 A; A/B=445-559, A/B=682-820
# PDB	3FVO	X-ray; 1.50 A; A/B=445-559, A/B=682-820
# PDB	4MF3	X-ray; 3.00 A; A/B=443-559, A/B=682-822
# PIR	I58178	I58178
# PRINTS	PR00177	NMDARECEPTOR
# Pfam	PF00060	Lig_chan
# Pfam	PF01094	ANF_receptor
# Pfam	PF10613	Lig_chan-Glu_bd
# Proteomes	UP000005640	Chromosome 21
# RNA EDITING	Modified_positions=636 {ECO:0000269|PubMed	7696618}; Note=Partially edited.; 
# Reactome	R-HSA-451307	Activation of Na-permeable Kainate Receptors
# Reactome	R-HSA-451308	Activation of Ca-permeable Kainate Receptor
# RecName	GRIK1_HUMAN	Glutamate receptor ionotropic, kainate 1
# RefSeq	NP_000821	NM_000830.4. [P39086-1]
# RefSeq	NP_001307545	NM_001320616.1
# RefSeq	NP_001307547	NM_001320618.1
# RefSeq	NP_783300	NM_175611.2. [P39086-2]
# SIMILARITY	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK1 subfamily. {ECO	0000305}.
# SMART	SM00079	PBPe
# SMART	SM00918	Lig_chan-Glu_bd
# SUBCELLULAR LOCATION	GRIK1_HUMAN	Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers (Probable). The unedited version (Q) assembles into a functional kainate-gated homomeric channel, whereas the edited version (R) is unable to produce channel activity when expressed alone. Both edited and unedited versions can form functional channels with GRIK4 and GRIK5. Interacts with KLHL17 (By similarity). {ECO:0000250, ECO	0000305}. 
# SUPFAM	SSF53822	SSF53822
# TISSUE SPECIFICITY	GRIK1_HUMAN	Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus. 
# UCSC	uc002ynn	human. [P39086-1]
# eggNOG	ENOG410XPSH	LUCA
# eggNOG	KOG1054	Eukaryota
BLAST	swissprot:GRIK1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GRIK1_HUMAN
BioCyc	ZFISH:ENSG00000171189-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000171189-MONOMER
COXPRESdb	2897	http://coxpresdb.jp/data/gene/2897.shtml
CleanEx	HS_GRIK1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GRIK1
DOI	10.1097/00041444-200109000-00005	http://dx.doi.org/10.1097/00041444-200109000-00005
DrugBank	DB00273	http://www.drugbank.ca/drugs/DB00273
EMBL	AJ249208	http://www.ebi.ac.uk/ena/data/view/AJ249208
EMBL	L19058	http://www.ebi.ac.uk/ena/data/view/L19058
EMBL	U16125	http://www.ebi.ac.uk/ena/data/view/U16125
Ensembl	ENST00000389125	http://www.ensembl.org/id/ENST00000389125
Ensembl	ENST00000399907	http://www.ensembl.org/id/ENST00000399907
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0005234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005234
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_function	GO:0015277	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015277
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007215
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007399	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007399
GO_process	GO:0007417	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007417
GO_process	GO:0051966	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051966
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GeneCards	GRIK1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GRIK1
GeneID	2897	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2897
GeneTree	ENSGT00760000118920	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118920
HGNC	HGNC:4579	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4579
HOGENOM	HOG000234371	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234371&db=HOGENOM6
HOVERGEN	HBG051839	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051839&db=HOVERGEN
HPA	HPA014623	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014623
InParanoid	P39086	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39086
InterPro	IPR001320	http://www.ebi.ac.uk/interpro/entry/IPR001320
InterPro	IPR001508	http://www.ebi.ac.uk/interpro/entry/IPR001508
InterPro	IPR001828	http://www.ebi.ac.uk/interpro/entry/IPR001828
InterPro	IPR019594	http://www.ebi.ac.uk/interpro/entry/IPR019594
InterPro	IPR028082	http://www.ebi.ac.uk/interpro/entry/IPR028082
Jabion	2897	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2897
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:2897	http://www.genome.jp/dbget-bin/www_bget?hsa:2897
KEGG_Orthology	KO:K05201	http://www.genome.jp/dbget-bin/www_bget?KO:K05201
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
MIM	138245	http://www.ncbi.nlm.nih.gov/omim/138245
PDB	2ZNS	http://www.ebi.ac.uk/pdbe-srv/view/entry/2ZNS
PDB	2ZNT	http://www.ebi.ac.uk/pdbe-srv/view/entry/2ZNT
PDB	2ZNU	http://www.ebi.ac.uk/pdbe-srv/view/entry/2ZNU
PDB	3FUZ	http://www.ebi.ac.uk/pdbe-srv/view/entry/3FUZ
PDB	3FV1	http://www.ebi.ac.uk/pdbe-srv/view/entry/3FV1
PDB	3FV2	http://www.ebi.ac.uk/pdbe-srv/view/entry/3FV2
PDB	3FVG	http://www.ebi.ac.uk/pdbe-srv/view/entry/3FVG
PDB	3FVK	http://www.ebi.ac.uk/pdbe-srv/view/entry/3FVK
PDB	3FVN	http://www.ebi.ac.uk/pdbe-srv/view/entry/3FVN
PDB	3FVO	http://www.ebi.ac.uk/pdbe-srv/view/entry/3FVO
PDB	4MF3	http://www.ebi.ac.uk/pdbe-srv/view/entry/4MF3
PDBsum	2ZNS	http://www.ebi.ac.uk/pdbsum/2ZNS
PDBsum	2ZNT	http://www.ebi.ac.uk/pdbsum/2ZNT
PDBsum	2ZNU	http://www.ebi.ac.uk/pdbsum/2ZNU
PDBsum	3FUZ	http://www.ebi.ac.uk/pdbsum/3FUZ
PDBsum	3FV1	http://www.ebi.ac.uk/pdbsum/3FV1
PDBsum	3FV2	http://www.ebi.ac.uk/pdbsum/3FV2
PDBsum	3FVG	http://www.ebi.ac.uk/pdbsum/3FVG
PDBsum	3FVK	http://www.ebi.ac.uk/pdbsum/3FVK
PDBsum	3FVN	http://www.ebi.ac.uk/pdbsum/3FVN
PDBsum	3FVO	http://www.ebi.ac.uk/pdbsum/3FVO
PDBsum	4MF3	http://www.ebi.ac.uk/pdbsum/4MF3
PRINTS	PR00177	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00177
PSORT	swissprot:GRIK1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GRIK1_HUMAN
PSORT-B	swissprot:GRIK1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GRIK1_HUMAN
PSORT2	swissprot:GRIK1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GRIK1_HUMAN
Pfam	PF00060	http://pfam.xfam.org/family/PF00060
Pfam	PF01094	http://pfam.xfam.org/family/PF01094
Pfam	PF10613	http://pfam.xfam.org/family/PF10613
PharmGKB	PA28973	http://www.pharmgkb.org/do/serve?objId=PA28973&objCls=Gene
Phobius	swissprot:GRIK1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GRIK1_HUMAN
PhylomeDB	P39086	http://phylomedb.org/?seqid=P39086
ProteinModelPortal	P39086	http://www.proteinmodelportal.org/query/uniprot/P39086
PubMed	11702055	http://www.ncbi.nlm.nih.gov/pubmed/11702055
PubMed	7696618	http://www.ncbi.nlm.nih.gov/pubmed/7696618
PubMed	8260617	http://www.ncbi.nlm.nih.gov/pubmed/8260617
PubMed	8589992	http://www.ncbi.nlm.nih.gov/pubmed/8589992
Reactome	R-HSA-451307	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-451307
Reactome	R-HSA-451308	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-451308
RefSeq	NP_000821	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000821
RefSeq	NP_001307545	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001307545
RefSeq	NP_001307547	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001307547
RefSeq	NP_783300	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_783300
SMART	SM00079	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00079
SMART	SM00918	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00918
SMR	P39086	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39086
STRING	9606.ENSP00000382791	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000382791&targetmode=cogs
SUPFAM	SSF53822	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822
UCSC	uc002ynn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ynn&org=rat
UniGene	Hs.664641	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.664641
UniGene	Hs.670516	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.670516
UniProtKB	GRIK1_HUMAN	http://www.uniprot.org/uniprot/GRIK1_HUMAN
UniProtKB-AC	P39086	http://www.uniprot.org/uniprot/P39086
charge	swissprot:GRIK1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GRIK1_HUMAN
eggNOG	ENOG410XPSH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPSH
eggNOG	KOG1054	http://eggnogapi.embl.de/nog_data/html/tree/KOG1054
epestfind	swissprot:GRIK1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GRIK1_HUMAN
garnier	swissprot:GRIK1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GRIK1_HUMAN
helixturnhelix	swissprot:GRIK1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GRIK1_HUMAN
hmoment	swissprot:GRIK1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GRIK1_HUMAN
iep	swissprot:GRIK1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GRIK1_HUMAN
inforesidue	swissprot:GRIK1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GRIK1_HUMAN
neXtProt	NX_P39086	http://www.nextprot.org/db/entry/NX_P39086
octanol	swissprot:GRIK1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GRIK1_HUMAN
pepcoil	swissprot:GRIK1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GRIK1_HUMAN
pepdigest	swissprot:GRIK1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GRIK1_HUMAN
pepinfo	swissprot:GRIK1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GRIK1_HUMAN
pepnet	swissprot:GRIK1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GRIK1_HUMAN
pepstats	swissprot:GRIK1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GRIK1_HUMAN
pepwheel	swissprot:GRIK1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GRIK1_HUMAN
pepwindow	swissprot:GRIK1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GRIK1_HUMAN
sigcleave	swissprot:GRIK1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GRIK1_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNKI_HUMAN	TWIK-related individual potassium channel
# AltName	KCNKI_HUMAN	TWIK-related spinal cord potassium channel
# BioGrid	130759	2
# DISEASE	KCNKI_HUMAN	Migraine with or without aura 13 (MGR13) [MIM 613656]  A form of migraine transmitted in an autosomal dominant pattern. Migraine is a disabling symptom complex of periodic headaches, usually temporal and unilateral. Headaches are often accompanied by irritability, nausea, vomiting and photophobia, preceded by constriction of the cranial arteries. The two major subtypes are common migraine (migraine without aura) and classic migraine (migraine with aura). Classic migraine is characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as blurred vision, hallucinations, vertigo, numbness and difficulty in concentrating and speaking. {ECO 0000269|PubMed 20871611}. Note=The disease is caused by mutations affecting the gene represented in this entry. Susceptibility to migraine has been shown to be conferred by a frameshift mutation that segregates with the disorder in a large multigenerational family. Migraine was associated with sensitivity to lights, sounds, and smells, as well as nausea and occasional vomiting. Triggers included fatigue, alcohol and bright lights. Mutations in KCNK18 are a rare cause of migraine. 
# Ensembl	ENST00000334549	ENSP00000334650; ENSG00000186795
# FUNCTION	KCNKI_HUMAN	Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation (By similarity). {ECO 0000250, ECO 0000269|PubMed 12754259, ECO 0000269|PubMed 15562060}. 
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IC:BHF-UCL.
# GO_function	GO:0005267	potassium channel activity; TAS:Reactome.
# GO_function	GO:0015269	calcium-activated potassium channel activity; IEA:Ensembl.
# GO_function	GO:0015271	outward rectifier potassium channel activity; IDA:BHF-UCL.
# GO_function	GO:0022841	potassium ion leak channel activity; IBA:GO_Central.
# GO_process	GO:0006813	potassium ion transport; IDA:UniProtKB.
# GO_process	GO:0030322	stabilization of membrane potential; IBA:GO_Central.
# GO_process	GO:0071435	potassium ion export; IDA:BHF-UCL.
# GO_process	GO:0071467	cellular response to pH; IDA:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# HGNC	HGNC:19439	KCNK18
# InterPro	IPR003280	2pore_dom_K_chnl
# InterPro	IPR013099	K_chnl_dom
# MIM	613655	gene
# MIM	613656	phenotype
# MISCELLANEOUS	KCNKI_HUMAN	In contrast to its mouse ortholog, it is not regulated by extracellular protons. 
# Organism	KCNKI_HUMAN	Homo sapiens (Human)
# PRINTS	PR01333	2POREKCHANEL
# PTM	KCNKI_HUMAN	N-glycosylated. {ECO 0000269|PubMed 20006580}. 
# PTM	KCNKI_HUMAN	Phosphorylation of Ser-252 is required for the binding of 14- 3-3eta/YWHAH. Calcineurin-mediated dephosphorylation of Ser-264 enhances channel activity (By similarity). {ECO 0000250}. 
# Pfam	PF07885	Ion_trans_2; 2
# Proteomes	UP000005640	Chromosome 10
# Reactome	R-HSA-1299344	TWIK-related spinal cord K+ channel (TRESK)
# Reactome	R-HSA-5576886	Phase 4 - resting membrane potential
# RecName	KCNKI_HUMAN	Potassium channel subfamily K member 18
# RefSeq	NP_862823	NM_181840.1
# SIMILARITY	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	KCNKI_HUMAN	Cell membrane {ECO 0000269|PubMed 20006580}; Multi-pass membrane protein {ECO 0000269|PubMed 20006580}. 
# SUBUNIT	Interacts with calcineurin. Interacts with YWHAH, in a phosphorylation-dependent manner. {ECO	0000250}. 
# TISSUE SPECIFICITY	KCNKI_HUMAN	Expressed specifically in dorsal root ganglion and trigeminal ganglion neurons. Detected at low levels in spinal cord. {ECO 0000269|PubMed 12754259, ECO 0000269|PubMed 15562060, ECO 0000269|PubMed 20871611}. 
# UCSC	uc010qsr	human
# WEB RESOURCE	KCNKI_HUMAN	Name=Protein Spotlight; Note=Throb - Issue 124 of December 2010; URL="http //web.expasy.org/spotlight/back_issues/124";
# eggNOG	COG1226	LUCA
# eggNOG	KOG1418	Eukaryota
BLAST	swissprot:KCNKI_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNKI_HUMAN
BioCyc	ZFISH:G66-33339-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33339-MONOMER
COXPRESdb	338567	http://coxpresdb.jp/data/gene/338567.shtml
CleanEx	HS_KCNK18	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNK18
DOI	10.1016/j.bbrc.2009.12.056	http://dx.doi.org/10.1016/j.bbrc.2009.12.056
DOI	10.1038/nature02462	http://dx.doi.org/10.1038/nature02462
DOI	10.1038/nm.2216	http://dx.doi.org/10.1038/nm.2216
DOI	10.1074/jbc.M206810200	http://dx.doi.org/10.1074/jbc.M206810200
DOI	10.1113/jphysiol.2007.145649	http://dx.doi.org/10.1113/jphysiol.2007.145649
DOI	10.1213/01.ANE.0000136849.07384.44	http://dx.doi.org/10.1213/01.ANE.0000136849.07384.44
EMBL	AB087138	http://www.ebi.ac.uk/ena/data/view/AB087138
EMBL	AL731557	http://www.ebi.ac.uk/ena/data/view/AL731557
Ensembl	ENST00000334549	http://www.ensembl.org/id/ENST00000334549
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_function	GO:0015269	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015269
GO_function	GO:0015271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015271
GO_function	GO:0022841	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022841
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0030322	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030322
GO_process	GO:0071435	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071435
GO_process	GO:0071467	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071467
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	KCNK18	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNK18
GeneID	338567	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=338567
GeneTree	ENSGT00700000104522	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00700000104522
HGNC	HGNC:19439	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:19439
HOGENOM	HOG000074045	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000074045&db=HOGENOM6
HOVERGEN	HBG104673	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG104673&db=HOVERGEN
HPA	HPA044739	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA044739
InParanoid	Q7Z418	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q7Z418
InterPro	IPR003280	http://www.ebi.ac.uk/interpro/entry/IPR003280
InterPro	IPR013099	http://www.ebi.ac.uk/interpro/entry/IPR013099
Jabion	338567	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=338567
KEGG_Gene	hsa:338567	http://www.genome.jp/dbget-bin/www_bget?hsa:338567
MIM	613655	http://www.ncbi.nlm.nih.gov/omim/613655
MIM	613656	http://www.ncbi.nlm.nih.gov/omim/613656
OMA	AFKLVQN	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AFKLVQN
OrthoDB	EOG091G0B4G	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0B4G
PRINTS	PR01333	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01333
PSORT	swissprot:KCNKI_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNKI_HUMAN
PSORT-B	swissprot:KCNKI_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNKI_HUMAN
PSORT2	swissprot:KCNKI_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNKI_HUMAN
Pfam	PF07885	http://pfam.xfam.org/family/PF07885
PharmGKB	PA134985465	http://www.pharmgkb.org/do/serve?objId=PA134985465&objCls=Gene
Phobius	swissprot:KCNKI_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNKI_HUMAN
PhylomeDB	Q7Z418	http://phylomedb.org/?seqid=Q7Z418
ProteinModelPortal	Q7Z418	http://www.proteinmodelportal.org/query/uniprot/Q7Z418
PubMed	12754259	http://www.ncbi.nlm.nih.gov/pubmed/12754259
PubMed	15164054	http://www.ncbi.nlm.nih.gov/pubmed/15164054
PubMed	15562060	http://www.ncbi.nlm.nih.gov/pubmed/15562060
PubMed	17962323	http://www.ncbi.nlm.nih.gov/pubmed/17962323
PubMed	20006580	http://www.ncbi.nlm.nih.gov/pubmed/20006580
PubMed	20871611	http://www.ncbi.nlm.nih.gov/pubmed/20871611
Reactome	R-HSA-1299344	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1299344
Reactome	R-HSA-5576886	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576886
RefSeq	NP_862823	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_862823
STRING	9606.ENSP00000334650	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000334650&targetmode=cogs
UCSC	uc010qsr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010qsr&org=rat
UniGene	Hs.449650	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.449650
UniProtKB	KCNKI_HUMAN	http://www.uniprot.org/uniprot/KCNKI_HUMAN
UniProtKB-AC	Q7Z418	http://www.uniprot.org/uniprot/Q7Z418
charge	swissprot:KCNKI_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNKI_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG1418	http://eggnogapi.embl.de/nog_data/html/tree/KOG1418
epestfind	swissprot:KCNKI_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNKI_HUMAN
garnier	swissprot:KCNKI_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNKI_HUMAN
helixturnhelix	swissprot:KCNKI_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNKI_HUMAN
hmoment	swissprot:KCNKI_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNKI_HUMAN
iep	swissprot:KCNKI_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNKI_HUMAN
inforesidue	swissprot:KCNKI_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNKI_HUMAN
neXtProt	NX_Q7Z418	http://www.nextprot.org/db/entry/NX_Q7Z418
octanol	swissprot:KCNKI_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNKI_HUMAN
pepcoil	swissprot:KCNKI_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNKI_HUMAN
pepdigest	swissprot:KCNKI_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNKI_HUMAN
pepinfo	swissprot:KCNKI_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNKI_HUMAN
pepnet	swissprot:KCNKI_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNKI_HUMAN
pepstats	swissprot:KCNKI_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNKI_HUMAN
pepwheel	swissprot:KCNKI_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNKI_HUMAN
pepwindow	swissprot:KCNKI_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNKI_HUMAN
sigcleave	swissprot:KCNKI_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNKI_HUMAN
## Database	ID	URL or Descriptions
# AltName	COX2_HUMAN	Cytochrome c oxidase polypeptide II
# BioGrid	110616	43
# COFACTOR	Name=Cu cation; Xref=ChEBI:CHEBI	23378; Note=Binds a copper A center.; 
# DISEASE	COX2_HUMAN	Mitochondrial complex IV deficiency (MT-C4D) [MIM 220110]  A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, exercise intolerance, developmental delay, delayed motor development and mental retardation. Some affected individuals manifest a fatal hypertrophic cardiomyopathy resulting in neonatal death. A subset of patients manifest Leigh syndrome. {ECO 0000269|PubMed 10486321}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB02659	Cholic Acid
# Ensembl	ENST00000361739	ENSP00000354876; ENSG00000198712
# ExpressionAtlas	P00403	baseline and differential
# FUNCTION	COX2_HUMAN	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1. 
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0005751	mitochondrial respiratory chain complex IV; IBA:GO_Central.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0045277	respiratory chain complex IV; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0004129	cytochrome-c oxidase activity; NAS:UniProtKB.
# GO_function	GO:0005507	copper ion binding; IEA:InterPro.
# GO_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen; NAS:UniProtKB.
# GO_process	GO:0007595	lactation; IEA:Ensembl.
# GO_process	GO:0009409	response to cold; IEA:Ensembl.
# GO_process	GO:0042773	ATP synthesis coupled electron transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# Gene3D	1.10.287.90	-; 1.
# Gene3D	2.60.40.420	-; 1.
# Genevisible	P00403	HS
# HGNC	HGNC:7421	MT-CO2
# INTERACTION	COX2_HUMAN	P49281-3 SLC11A2; NbExp=2; IntAct=EBI-2105756, EBI-10828817; 
# IntAct	P00403	29
# InterPro	IPR001505	Copper_CuA
# InterPro	IPR002429	Cyt_c_oxidase_su2_C
# InterPro	IPR008972	Cupredoxin
# InterPro	IPR011759	Cyt_c_oxidase_su2_TM_dom
# InterPro	IPR014222	Cyt_c_oxidase_su2
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Disease	H01368:[Inherited metabolic disease; Mitochondrial disease] Leber Hereditary Optic Neuropathy (LHON) [DS	H00068]
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	220110	phenotype
# MIM	516040	gene
# Organism	COX2_HUMAN	Homo sapiens (Human)
# Orphanet	254905	Isolated cytochrome C oxidase deficiency
# Orphanet	255210	Maternally-inherited Leigh syndrome
# Orphanet	550	MELAS
# PDB	3VRJ	X-ray; 1.90 A; C=46-55
# PIR	A00472	OBHU2
# PROSITE	PS00078	COX2
# PROSITE	PS50857	COX2_CUA
# PROSITE	PS50999	COX2_TM
# Pfam	PF00116	COX2
# Pfam	PF02790	COX2_TM
# Proteomes	UP000005640	Mitochondrion
# Reactome	R-HSA-5628897	TP53 Regulates Metabolic Genes
# Reactome	R-HSA-611105	Respiratory electron transport
# RecName	COX2_HUMAN	Cytochrome c oxidase subunit 2
# RefSeq	YP_003024029	NC_012920.1
# SIMILARITY	Belongs to the cytochrome c oxidase subunit 2 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	COX2_HUMAN	Mitochondrion inner membrane; Multi-pass membrane protein. 
# SUPFAM	SSF49503	SSF49503
# SUPFAM	SSF81464	SSF81464
# TCDB	3.D.4.11	the proton-translocating cytochrome oxidase (cox) superfamily
# TIGRFAMs	TIGR02866	CoxB
# eggNOG	COG1622	LUCA
# eggNOG	KOG4767	Eukaryota
BLAST	swissprot:COX2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:COX2_HUMAN
BioCyc	ZFISH:HS00027-MONOMER	http://biocyc.org/getid?id=ZFISH:HS00027-MONOMER
COG	COG1622	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1622
COXPRESdb	4513	http://coxpresdb.jp/data/gene/4513.shtml
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1007/BF00206061	http://dx.doi.org/10.1007/BF00206061
DOI	10.1007/s00414-004-0427-6	http://dx.doi.org/10.1007/s00414-004-0427-6
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/282189a0	http://dx.doi.org/10.1038/282189a0
DOI	10.1038/290457a0	http://dx.doi.org/10.1038/290457a0
DOI	10.1038/3108	http://dx.doi.org/10.1038/3108
DOI	10.1038/35047064	http://dx.doi.org/10.1038/35047064
DOI	10.1073/pnas.92.2.532	http://dx.doi.org/10.1073/pnas.92.2.532
DOI	10.1086/302590	http://dx.doi.org/10.1086/302590
DOI	10.1093/molbev/msg230	http://dx.doi.org/10.1093/molbev/msg230
DOI	10.1093/nar/17.16.6734	http://dx.doi.org/10.1093/nar/17.16.6734
DOI	10.1101/gr.686603	http://dx.doi.org/10.1101/gr.686603
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DrugBank	DB02659	http://www.drugbank.ca/drugs/DB02659
EMBL	AF004339	http://www.ebi.ac.uk/ena/data/view/AF004339
EMBL	AF346963	http://www.ebi.ac.uk/ena/data/view/AF346963
EMBL	AF346964	http://www.ebi.ac.uk/ena/data/view/AF346964
EMBL	AF346965	http://www.ebi.ac.uk/ena/data/view/AF346965
EMBL	AF346966	http://www.ebi.ac.uk/ena/data/view/AF346966
EMBL	AF346967	http://www.ebi.ac.uk/ena/data/view/AF346967
EMBL	AF346970	http://www.ebi.ac.uk/ena/data/view/AF346970
EMBL	AF346972	http://www.ebi.ac.uk/ena/data/view/AF346972
EMBL	AF346973	http://www.ebi.ac.uk/ena/data/view/AF346973
EMBL	AF346974	http://www.ebi.ac.uk/ena/data/view/AF346974
EMBL	AF346975	http://www.ebi.ac.uk/ena/data/view/AF346975
EMBL	AF346976	http://www.ebi.ac.uk/ena/data/view/AF346976
EMBL	AF346977	http://www.ebi.ac.uk/ena/data/view/AF346977
EMBL	AF346978	http://www.ebi.ac.uk/ena/data/view/AF346978
EMBL	AF346979	http://www.ebi.ac.uk/ena/data/view/AF346979
EMBL	AF346980	http://www.ebi.ac.uk/ena/data/view/AF346980
EMBL	AF346981	http://www.ebi.ac.uk/ena/data/view/AF346981
EMBL	AF346982	http://www.ebi.ac.uk/ena/data/view/AF346982
EMBL	AF346983	http://www.ebi.ac.uk/ena/data/view/AF346983
EMBL	AF346984	http://www.ebi.ac.uk/ena/data/view/AF346984
EMBL	AF346985	http://www.ebi.ac.uk/ena/data/view/AF346985
EMBL	AF346986	http://www.ebi.ac.uk/ena/data/view/AF346986
EMBL	AF346988	http://www.ebi.ac.uk/ena/data/view/AF346988
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EMBL	AY495121	http://www.ebi.ac.uk/ena/data/view/AY495121
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EMBL	AY495126	http://www.ebi.ac.uk/ena/data/view/AY495126
EMBL	AY495127	http://www.ebi.ac.uk/ena/data/view/AY495127
EMBL	AY495128	http://www.ebi.ac.uk/ena/data/view/AY495128
EMBL	AY495129	http://www.ebi.ac.uk/ena/data/view/AY495129
EMBL	AY495130	http://www.ebi.ac.uk/ena/data/view/AY495130
EMBL	AY495131	http://www.ebi.ac.uk/ena/data/view/AY495131
EMBL	AY495132	http://www.ebi.ac.uk/ena/data/view/AY495132
EMBL	AY495133	http://www.ebi.ac.uk/ena/data/view/AY495133
EMBL	AY495134	http://www.ebi.ac.uk/ena/data/view/AY495134
EMBL	AY495135	http://www.ebi.ac.uk/ena/data/view/AY495135
EMBL	AY495136	http://www.ebi.ac.uk/ena/data/view/AY495136
EMBL	AY495137	http://www.ebi.ac.uk/ena/data/view/AY495137
EMBL	AY495138	http://www.ebi.ac.uk/ena/data/view/AY495138
EMBL	AY495139	http://www.ebi.ac.uk/ena/data/view/AY495139
EMBL	AY495140	http://www.ebi.ac.uk/ena/data/view/AY495140
EMBL	AY495141	http://www.ebi.ac.uk/ena/data/view/AY495141
EMBL	AY495142	http://www.ebi.ac.uk/ena/data/view/AY495142
EMBL	AY495143	http://www.ebi.ac.uk/ena/data/view/AY495143
EMBL	AY495144	http://www.ebi.ac.uk/ena/data/view/AY495144
EMBL	AY495145	http://www.ebi.ac.uk/ena/data/view/AY495145
EMBL	AY495146	http://www.ebi.ac.uk/ena/data/view/AY495146
EMBL	AY495147	http://www.ebi.ac.uk/ena/data/view/AY495147
EMBL	AY495148	http://www.ebi.ac.uk/ena/data/view/AY495148
EMBL	AY495149	http://www.ebi.ac.uk/ena/data/view/AY495149
EMBL	AY495150	http://www.ebi.ac.uk/ena/data/view/AY495150
EMBL	AY495151	http://www.ebi.ac.uk/ena/data/view/AY495151
EMBL	AY495152	http://www.ebi.ac.uk/ena/data/view/AY495152
EMBL	AY495153	http://www.ebi.ac.uk/ena/data/view/AY495153
EMBL	AY495154	http://www.ebi.ac.uk/ena/data/view/AY495154
EMBL	AY495155	http://www.ebi.ac.uk/ena/data/view/AY495155
EMBL	AY495156	http://www.ebi.ac.uk/ena/data/view/AY495156
EMBL	AY495157	http://www.ebi.ac.uk/ena/data/view/AY495157
EMBL	AY495158	http://www.ebi.ac.uk/ena/data/view/AY495158
EMBL	AY495159	http://www.ebi.ac.uk/ena/data/view/AY495159
EMBL	AY495160	http://www.ebi.ac.uk/ena/data/view/AY495160
EMBL	AY495161	http://www.ebi.ac.uk/ena/data/view/AY495161
EMBL	AY495162	http://www.ebi.ac.uk/ena/data/view/AY495162
EMBL	AY495163	http://www.ebi.ac.uk/ena/data/view/AY495163
EMBL	AY495164	http://www.ebi.ac.uk/ena/data/view/AY495164
EMBL	AY495166	http://www.ebi.ac.uk/ena/data/view/AY495166
EMBL	AY495167	http://www.ebi.ac.uk/ena/data/view/AY495167
EMBL	AY495168	http://www.ebi.ac.uk/ena/data/view/AY495168
EMBL	AY495169	http://www.ebi.ac.uk/ena/data/view/AY495169
EMBL	AY495170	http://www.ebi.ac.uk/ena/data/view/AY495170
EMBL	AY495172	http://www.ebi.ac.uk/ena/data/view/AY495172
EMBL	AY495173	http://www.ebi.ac.uk/ena/data/view/AY495173
EMBL	AY495174	http://www.ebi.ac.uk/ena/data/view/AY495174
EMBL	AY495175	http://www.ebi.ac.uk/ena/data/view/AY495175
EMBL	AY495176	http://www.ebi.ac.uk/ena/data/view/AY495176
EMBL	AY495177	http://www.ebi.ac.uk/ena/data/view/AY495177
EMBL	AY495178	http://www.ebi.ac.uk/ena/data/view/AY495178
EMBL	AY495179	http://www.ebi.ac.uk/ena/data/view/AY495179
EMBL	AY495180	http://www.ebi.ac.uk/ena/data/view/AY495180
EMBL	AY495181	http://www.ebi.ac.uk/ena/data/view/AY495181
EMBL	AY495182	http://www.ebi.ac.uk/ena/data/view/AY495182
EMBL	AY495183	http://www.ebi.ac.uk/ena/data/view/AY495183
EMBL	AY495184	http://www.ebi.ac.uk/ena/data/view/AY495184
EMBL	AY495185	http://www.ebi.ac.uk/ena/data/view/AY495185
EMBL	AY495186	http://www.ebi.ac.uk/ena/data/view/AY495186
EMBL	AY495187	http://www.ebi.ac.uk/ena/data/view/AY495187
EMBL	AY495188	http://www.ebi.ac.uk/ena/data/view/AY495188
EMBL	AY495189	http://www.ebi.ac.uk/ena/data/view/AY495189
EMBL	AY495190	http://www.ebi.ac.uk/ena/data/view/AY495190
EMBL	AY495191	http://www.ebi.ac.uk/ena/data/view/AY495191
EMBL	AY495192	http://www.ebi.ac.uk/ena/data/view/AY495192
EMBL	AY495193	http://www.ebi.ac.uk/ena/data/view/AY495193
EMBL	AY495194	http://www.ebi.ac.uk/ena/data/view/AY495194
EMBL	AY495195	http://www.ebi.ac.uk/ena/data/view/AY495195
EMBL	AY495196	http://www.ebi.ac.uk/ena/data/view/AY495196
EMBL	AY495197	http://www.ebi.ac.uk/ena/data/view/AY495197
EMBL	AY495198	http://www.ebi.ac.uk/ena/data/view/AY495198
EMBL	AY495199	http://www.ebi.ac.uk/ena/data/view/AY495199
EMBL	AY495200	http://www.ebi.ac.uk/ena/data/view/AY495200
EMBL	AY495201	http://www.ebi.ac.uk/ena/data/view/AY495201
EMBL	AY495202	http://www.ebi.ac.uk/ena/data/view/AY495202
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EMBL	AY495329	http://www.ebi.ac.uk/ena/data/view/AY495329
EMBL	AY495330	http://www.ebi.ac.uk/ena/data/view/AY495330
EMBL	D38112	http://www.ebi.ac.uk/ena/data/view/D38112
EMBL	J01415	http://www.ebi.ac.uk/ena/data/view/J01415
EMBL	M25171	http://www.ebi.ac.uk/ena/data/view/M25171
EMBL	U12690	http://www.ebi.ac.uk/ena/data/view/U12690
EMBL	U12691	http://www.ebi.ac.uk/ena/data/view/U12691
EMBL	U12692	http://www.ebi.ac.uk/ena/data/view/U12692
EMBL	U12693	http://www.ebi.ac.uk/ena/data/view/U12693
EMBL	U12694	http://www.ebi.ac.uk/ena/data/view/U12694
EMBL	V00662	http://www.ebi.ac.uk/ena/data/view/V00662
EMBL	X15759	http://www.ebi.ac.uk/ena/data/view/X15759
EMBL	X55654	http://www.ebi.ac.uk/ena/data/view/X55654
Ensembl	ENST00000361739	http://www.ensembl.org/id/ENST00000361739
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005751	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005751
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0045277	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045277
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0004129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004129
GO_function	GO:0005507	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005507
GO_process	GO:0006123	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006123
GO_process	GO:0007595	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007595
GO_process	GO:0009409	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009409
GO_process	GO:0042773	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042773
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
Gene3D	1.10.287.90	http://www.cathdb.info/version/latest/superfamily/1.10.287.90
Gene3D	2.60.40.420	http://www.cathdb.info/version/latest/superfamily/2.60.40.420
GeneCards	MT-CO2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=MT-CO2
GeneID	4513	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4513
GeneTree	ENSGT00390000017410	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000017410
H-InvDB	HIX0080298	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0080298
HGNC	HGNC:7421	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:7421
HOGENOM	HOG000264988	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264988&db=HOGENOM6
HOVERGEN	HBG012727	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG012727&db=HOVERGEN
HPA	CAB016243	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB016243
HPA	HPA051505	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA051505
HPA	HPA054758	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA054758
InParanoid	P00403	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00403
IntAct	P00403	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00403*
InterPro	IPR001505	http://www.ebi.ac.uk/interpro/entry/IPR001505
InterPro	IPR002429	http://www.ebi.ac.uk/interpro/entry/IPR002429
InterPro	IPR008972	http://www.ebi.ac.uk/interpro/entry/IPR008972
InterPro	IPR011759	http://www.ebi.ac.uk/interpro/entry/IPR011759
InterPro	IPR014222	http://www.ebi.ac.uk/interpro/entry/IPR014222
Jabion	4513	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=4513
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Disease	H01368	http://www.genome.jp/dbget-bin/www_bget?H01368
KEGG_Gene	hsa:4513	http://www.genome.jp/dbget-bin/www_bget?hsa:4513
KEGG_Orthology	KO:K02261	http://www.genome.jp/dbget-bin/www_bget?KO:K02261
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	220110	http://www.ncbi.nlm.nih.gov/omim/220110
MIM	516040	http://www.ncbi.nlm.nih.gov/omim/516040
MINT	MINT-2799304	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-2799304
OMA	PLKIFEM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PLKIFEM
Orphanet	254905	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=254905
Orphanet	255210	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=255210
Orphanet	550	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=550
OrthoDB	EOG091G0IO9	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0IO9
PDB	3VRJ	http://www.ebi.ac.uk/pdbe-srv/view/entry/3VRJ
PDBsum	3VRJ	http://www.ebi.ac.uk/pdbsum/3VRJ
PROSITE	PS00078	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00078
PROSITE	PS50857	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50857
PROSITE	PS50999	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50999
PSORT	swissprot:COX2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:COX2_HUMAN
PSORT-B	swissprot:COX2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:COX2_HUMAN
PSORT2	swissprot:COX2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:COX2_HUMAN
Pfam	PF00116	http://pfam.xfam.org/family/PF00116
Pfam	PF02790	http://pfam.xfam.org/family/PF02790
PharmGKB	PA31227	http://www.pharmgkb.org/do/serve?objId=PA31227&objCls=Gene
Phobius	swissprot:COX2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:COX2_HUMAN
PhylomeDB	P00403	http://phylomedb.org/?seqid=P00403
ProteinModelPortal	P00403	http://www.proteinmodelportal.org/query/uniprot/P00403
PubMed	10486321	http://www.ncbi.nlm.nih.gov/pubmed/10486321
PubMed	11130070	http://www.ncbi.nlm.nih.gov/pubmed/11130070
PubMed	12840039	http://www.ncbi.nlm.nih.gov/pubmed/12840039
PubMed	12949126	http://www.ncbi.nlm.nih.gov/pubmed/12949126
PubMed	14760490	http://www.ncbi.nlm.nih.gov/pubmed/14760490
PubMed	1757091	http://www.ncbi.nlm.nih.gov/pubmed/1757091
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	226894	http://www.ncbi.nlm.nih.gov/pubmed/226894
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	2550900	http://www.ncbi.nlm.nih.gov/pubmed/2550900
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	7219534	http://www.ncbi.nlm.nih.gov/pubmed/7219534
PubMed	7530363	http://www.ncbi.nlm.nih.gov/pubmed/7530363
PubMed	8277847	http://www.ncbi.nlm.nih.gov/pubmed/8277847
PubMed	9806551	http://www.ncbi.nlm.nih.gov/pubmed/9806551
Reactome	R-HSA-5628897	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5628897
Reactome	R-HSA-611105	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-611105
RefSeq	YP_003024029	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_003024029
SMR	P00403	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00403
STRING	9606.ENSP00000354876	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000354876&targetmode=cogs
STRING	COG1622	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1622&targetmode=cogs
SUPFAM	SSF49503	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49503
SUPFAM	SSF81464	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81464
TCDB	3.D.4.11	http://www.tcdb.org/search/result.php?tc=3.D.4.11
TIGRFAMs	TIGR02866	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02866
UniProtKB	COX2_HUMAN	http://www.uniprot.org/uniprot/COX2_HUMAN
UniProtKB-AC	P00403	http://www.uniprot.org/uniprot/P00403
charge	swissprot:COX2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:COX2_HUMAN
eggNOG	COG1622	http://eggnogapi.embl.de/nog_data/html/tree/COG1622
eggNOG	KOG4767	http://eggnogapi.embl.de/nog_data/html/tree/KOG4767
epestfind	swissprot:COX2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:COX2_HUMAN
garnier	swissprot:COX2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:COX2_HUMAN
helixturnhelix	swissprot:COX2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:COX2_HUMAN
hmoment	swissprot:COX2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:COX2_HUMAN
iep	swissprot:COX2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:COX2_HUMAN
inforesidue	swissprot:COX2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:COX2_HUMAN
neXtProt	NX_P00403	http://www.nextprot.org/db/entry/NX_P00403
octanol	swissprot:COX2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:COX2_HUMAN
pepcoil	swissprot:COX2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:COX2_HUMAN
pepdigest	swissprot:COX2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:COX2_HUMAN
pepinfo	swissprot:COX2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:COX2_HUMAN
pepnet	swissprot:COX2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:COX2_HUMAN
pepstats	swissprot:COX2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:COX2_HUMAN
pepwheel	swissprot:COX2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:COX2_HUMAN
pepwindow	swissprot:COX2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:COX2_HUMAN
sigcleave	swissprot:COX2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:COX2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S13A2_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q13183-1; Sequence=Displayed; Name=2; IsoId=Q13183-2; Sequence=VSP_046426, VSP_046427; Note=No experimental confirmation available.; Name=3; IsoId=Q13183-3; Sequence=VSP_046427; Note=No experimental confirmation available.; 
# AltName	S13A2_HUMAN	Na(+)/dicarboxylate cotransporter 1
# AltName	S13A2_HUMAN	Renal sodium/dicarboxylate cotransporter
# BioGrid	114520	11
# CCDS	CCDS11231	-. [Q13183-1]
# CCDS	CCDS54098	-. [Q13183-3]
# DrugBank	DB00139	Succinic acid
# Ensembl	ENST00000314669	ENSP00000316202; ENSG00000007216. [Q13183-1]
# Ensembl	ENST00000444914	ENSP00000392411; ENSG00000007216. [Q13183-3]
# ExpressionAtlas	Q13183	baseline and differential
# FUNCTION	S13A2_HUMAN	Cotransport of sodium ions and dicarboxylates such as succinate and citrate. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	S13A2_HUMAN	GO 0015361 low-affinity sodium dicarboxylate symporter activity; TAS Reactome.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q13183	HS
# HGNC	HGNC:10917	SLC13A2
# InterPro	IPR001898	Na/sul_symport
# InterPro	IPR031312	Na/sul_symport_CS
# KEGG_Brite	ko02001	Solute carrier family
# MIM	604148	gene
# Organism	S13A2_HUMAN	Homo sapiens (Human)
# PROSITE	PS01271	NA_SULFATE
# Pfam	PF00939	Na_sulph_symp
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-433137	Sodium-coupled sulphate, di- and tri-carboxylate transporters
# RecName	S13A2_HUMAN	Solute carrier family 13 member 2
# RefSeq	NP_001139447	NM_001145975.1. [Q13183-3]
# RefSeq	NP_003975	NM_003984.3. [Q13183-1]
# SIMILARITY	Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	S13A2_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	2.A.47.1.17:the divalent anion	na(+) symporter (dass) family
# UCSC	uc002hbh	human. [Q13183-1]
BLAST	swissprot:S13A2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S13A2_HUMAN
BioCyc	ZFISH:ENSG00000007216-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000007216-MONOMER
COG	COG0471	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0471
COXPRESdb	9058	http://coxpresdb.jp/data/gene/9058.shtml
CleanEx	HS_SLC13A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC13A2
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1442-2042.2007.01554.x	http://dx.doi.org/10.1111/j.1442-2042.2007.01554.x
DrugBank	DB00139	http://www.drugbank.ca/drugs/DB00139
EMBL	AC015917	http://www.ebi.ac.uk/ena/data/view/AC015917
EMBL	AK298388	http://www.ebi.ac.uk/ena/data/view/AK298388
EMBL	AK314684	http://www.ebi.ac.uk/ena/data/view/AK314684
EMBL	BC096277	http://www.ebi.ac.uk/ena/data/view/BC096277
EMBL	BC096278	http://www.ebi.ac.uk/ena/data/view/BC096278
EMBL	BC096279	http://www.ebi.ac.uk/ena/data/view/BC096279
EMBL	U26209	http://www.ebi.ac.uk/ena/data/view/U26209
Ensembl	ENST00000314669	http://www.ensembl.org/id/ENST00000314669
Ensembl	ENST00000444914	http://www.ensembl.org/id/ENST00000444914
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0015361	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015361
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC13A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC13A2
GeneID	9058	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9058
GeneTree	ENSGT00550000074480	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074480
HGNC	HGNC:10917	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10917
HOGENOM	HOG000278432	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278432&db=HOGENOM6
HOVERGEN	HBG055339	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG055339&db=HOVERGEN
HPA	HPA014963	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014963
InParanoid	Q13183	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q13183
InterPro	IPR001898	http://www.ebi.ac.uk/interpro/entry/IPR001898
InterPro	IPR031312	http://www.ebi.ac.uk/interpro/entry/IPR031312
Jabion	9058	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9058
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:9058	http://www.genome.jp/dbget-bin/www_bget?hsa:9058
KEGG_Orthology	KO:K14445	http://www.genome.jp/dbget-bin/www_bget?KO:K14445
MIM	604148	http://www.ncbi.nlm.nih.gov/omim/604148
OMA	DKCRKLQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DKCRKLQ
OrthoDB	EOG091G092X	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G092X
PROSITE	PS01271	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01271
PSORT	swissprot:S13A2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S13A2_HUMAN
PSORT-B	swissprot:S13A2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S13A2_HUMAN
PSORT2	swissprot:S13A2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S13A2_HUMAN
Pfam	PF00939	http://pfam.xfam.org/family/PF00939
PharmGKB	PA382	http://www.pharmgkb.org/do/serve?objId=PA382&objCls=Gene
Phobius	swissprot:S13A2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S13A2_HUMAN
PhylomeDB	Q13183	http://phylomedb.org/?seqid=Q13183
ProteinModelPortal	Q13183	http://www.proteinmodelportal.org/query/uniprot/Q13183
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	17470169	http://www.ncbi.nlm.nih.gov/pubmed/17470169
PubMed	8967342	http://www.ncbi.nlm.nih.gov/pubmed/8967342
Reactome	R-HSA-433137	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-433137
RefSeq	NP_001139447	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001139447
RefSeq	NP_003975	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003975
STRING	COG0471	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0471&targetmode=cogs
TCDB	2.A.47.1.17	http://www.tcdb.org/search/result.php?tc=2.A.47.1.17
UCSC	uc002hbh	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002hbh&org=rat
UniGene	Hs.102307	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.102307
UniProtKB	S13A2_HUMAN	http://www.uniprot.org/uniprot/S13A2_HUMAN
UniProtKB-AC	Q13183	http://www.uniprot.org/uniprot/Q13183
charge	swissprot:S13A2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S13A2_HUMAN
epestfind	swissprot:S13A2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S13A2_HUMAN
garnier	swissprot:S13A2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S13A2_HUMAN
helixturnhelix	swissprot:S13A2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S13A2_HUMAN
hmoment	swissprot:S13A2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S13A2_HUMAN
iep	swissprot:S13A2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S13A2_HUMAN
inforesidue	swissprot:S13A2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S13A2_HUMAN
neXtProt	NX_Q13183	http://www.nextprot.org/db/entry/NX_Q13183
octanol	swissprot:S13A2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S13A2_HUMAN
pepcoil	swissprot:S13A2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S13A2_HUMAN
pepdigest	swissprot:S13A2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S13A2_HUMAN
pepinfo	swissprot:S13A2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S13A2_HUMAN
pepnet	swissprot:S13A2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S13A2_HUMAN
pepstats	swissprot:S13A2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S13A2_HUMAN
pepwheel	swissprot:S13A2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S13A2_HUMAN
pepwindow	swissprot:S13A2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S13A2_HUMAN
sigcleave	swissprot:S13A2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S13A2_HUMAN
## Database	ID	URL or Descriptions
# AltName	ABCA1_HUMAN	ATP-binding cassette transporter 1
# AltName	ABCA1_HUMAN	Cholesterol efflux regulatory protein
# BioGrid	106537	23
# ChiTaRS	ABCA1	human
# DISEASE	ABCA1_HUMAN	High density lipoprotein deficiency 1 (HDLD1) [MIM 205400]  Recessive disorder characterized by absence of high density lipoprotein (HDL) cholesterol from plasma, accumulation of cholesteryl esters, premature coronary artery disease (CAD), hepatosplenomegaly, recurrent peripheral neuropathy and progressive muscle wasting and weakness. {ECO 0000269|PubMed 10431236, ECO 0000269|PubMed 10431237, ECO 0000269|PubMed 10706591, ECO 0000269|PubMed 10938021, ECO 0000269|PubMed 11086027, ECO 0000269|PubMed 11257260, ECO 0000269|PubMed 11476961, ECO 0000269|PubMed 11476965, ECO 0000269|PubMed 11785958, ECO 0000269|PubMed 12111371, ECO 0000269|PubMed 12111381, ECO 0000269|PubMed 12407001, ECO 0000269|PubMed 14576201, ECO 0000269|PubMed 15019541, ECO 0000269|PubMed 15158913, ECO 0000269|PubMed 15262183, ECO 0000269|PubMed 15297675, ECO 0000269|PubMed 15520867}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ABCA1_HUMAN	High density lipoprotein deficiency 2 (HDLD2) [MIM 604091]  Inherited as autosomal dominant trait. It is characterized by moderately low HDL cholesterol, predilection toward premature coronary artery disease (CAD) and a reduction in cellular cholesterol efflux. {ECO 0000269|PubMed 10431236, ECO 0000269|PubMed 10533863, ECO 0000269|PubMed 11086027, ECO 0000269|PubMed 12009425, ECO 0000269|PubMed 12204794, ECO 0000269|PubMed 15722566}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	ABCA1_HUMAN	Multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. 
# DrugBank	DB00171	Adenosine triphosphate
# DrugBank	DB01016	Glyburide
# DrugBank	DB01599	Probucol
# Ensembl	ENST00000374736	ENSP00000363868; ENSG00000165029
# ExpressionAtlas	O95477	baseline and differential
# FUNCTION	ABCA1_HUMAN	cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport. 
# GO_component	GO:0005789	endoplasmic reticulum membrane; TAS:Reactome.
# GO_component	GO:0005794	Golgi apparatus; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0009897	external side of plasma membrane; IEA:Ensembl.
# GO_component	GO:0030139	endocytic vesicle; IDA:BHF-UCL.
# GO_component	GO:0034364	high-density lipoprotein particle; IEA:Ensembl.
# GO_component	GO:0045121	membrane raft; IDA:BHF-UCL.
# GO_component	GO:0045335	phagocytic vesicle; IDA:BHF-UCL.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IDA:BHF-UCL.
# GO_function	GO:0005102	receptor binding; IPI:BHF-UCL.
# GO_function	GO:0005524	ATP binding; IDA:BHF-UCL.
# GO_function	GO:0005543	phospholipid binding; IC:BHF-UCL.
# GO_function	GO:0005548	phospholipid transporter activity; IDA:BHF-UCL.
# GO_function	GO:0008509	anion transmembrane transporter activity; ISS:BHF-UCL.
# GO_function	GO:0015485	cholesterol binding; IC:BHF-UCL.
# GO_function	GO:0016887	ATPase activity; IDA:BHF-UCL.
# GO_function	GO:0017127	cholesterol transporter activity; IDA:BHF-UCL.
# GO_function	GO:0019905	syntaxin binding; IPI:BHF-UCL.
# GO_function	GO:0031267	small GTPase binding; IPI:BHF-UCL.
# GO_function	GO:0034185	apolipoprotein binding; IPI:BHF-UCL.
# GO_function	GO:0034186	apolipoprotein A-I binding; IPI:BHF-UCL.
# GO_function	GO:0034188	apolipoprotein A-I receptor activity; IDA:BHF-UCL.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; IBA:GO_Central.
# GO_function	GO:0051117	ATPase binding; IPI:BHF-UCL.
# GO_function	GO:0090554	phosphatidylcholine-translocating ATPase activity; IDA:BHF-UCL.
# GO_function	GO:0090556	phosphatidylserine-translocating ATPase activity; IDA:BHF-UCL.
# GO_process	GO:0002790	peptide secretion; IEA:Ensembl.
# GO_process	GO:0006497	protein lipidation; IEA:Ensembl.
# GO_process	GO:0006911	phagocytosis, engulfment; IEA:Ensembl.
# GO_process	GO:0007040	lysosome organization; IDA:BHF-UCL.
# GO_process	GO:0007186	G-protein coupled receptor signaling pathway; IMP:BHF-UCL.
# GO_process	GO:0007584	response to nutrient; IEA:Ensembl.
# GO_process	GO:0008203	cholesterol metabolic process; IDA:BHF-UCL.
# GO_process	GO:0010745	negative regulation of macrophage derived foam cell differentiation; TAS:BHF-UCL.
# GO_process	GO:0010875	positive regulation of cholesterol efflux; IMP:BHF-UCL.
# GO_process	GO:0010887	negative regulation of cholesterol storage; TAS:BHF-UCL.
# GO_process	GO:0016197	endosomal transport; IDA:BHF-UCL.
# GO_process	GO:0030819	positive regulation of cAMP biosynthetic process; IMP:BHF-UCL.
# GO_process	GO:0032367	intracellular cholesterol transport; IMP:BHF-UCL.
# GO_process	GO:0032489	regulation of Cdc42 protein signal transduction; IMP:BHF-UCL.
# GO_process	GO:0033344	cholesterol efflux; IDA:BHF-UCL.
# GO_process	GO:0033700	phospholipid efflux; IDA:BHF-UCL.
# GO_process	GO:0034380	high-density lipoprotein particle assembly; IMP:BHF-UCL.
# GO_process	GO:0034616	response to laminar fluid shear stress; IEP:BHF-UCL.
# GO_process	GO:0042157	lipoprotein metabolic process; TAS:Reactome.
# GO_process	GO:0042493	response to drug; IEA:Ensembl.
# GO_process	GO:0042632	cholesterol homeostasis; IDA:BHF-UCL.
# GO_process	GO:0043691	reverse cholesterol transport; IMP:BHF-UCL.
# GO_process	GO:0045332	phospholipid translocation; IDA:BHF-UCL.
# GO_process	GO:0050702	interleukin-1 beta secretion; IMP:BHF-UCL.
# GO_process	GO:0055091	phospholipid homeostasis; IMP:BHF-UCL.
# GO_process	GO:0055098	response to low-density lipoprotein particle; IEP:BHF-UCL.
# GO_process	GO:0060155	platelet dense granule organization; IMP:BHF-UCL.
# GO_process	GO:0071222	cellular response to lipopolysaccharide; IEA:Ensembl.
# GO_process	GO:0071300	cellular response to retinoic acid; IEA:Ensembl.
# GO_process	GO:0071397	cellular response to cholesterol; IEA:Ensembl.
# GO_process	GO:0090107	regulation of high-density lipoprotein particle assembly; TAS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0008289	lipid binding
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0061024	membrane organization
# GOslim_process	GO:0065003	macromolecular complex assembly
# Gene3D	3.40.50.300	-; 2.
# Genevisible	O95477	HS
# HGNC	HGNC:29	ABCA1
# INDUCTION	ABCA1_HUMAN	By bacterial lipopolysaccharides (LPS). LPS regulates expression through a liver X receptor (LXR) -independent mechanism. Repressed by ZNF202. {ECO 0000269|PubMed 11279031, ECO 0000269|PubMed 12032171}. 
# INTERACTION	ABCA1_HUMAN	Q86UK0 ABCA12; NbExp=4; IntAct=EBI-784112, EBI-9541582; P02647 APOA1; NbExp=4; IntAct=EBI-784112, EBI-701692; P60953 CDC42; NbExp=2; IntAct=EBI-784112, EBI-81752; P55055 NR1H2; NbExp=2; IntAct=EBI-784112, EBI-745354; Q13424 SNTA1; NbExp=2; IntAct=EBI-784112, EBI-717191; Q13884 SNTB1; NbExp=3; IntAct=EBI-784112, EBI-295843; Q86Y82 STX12; NbExp=9; IntAct=EBI-784112, EBI-2691717; 
# IntAct	O95477	23
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR026082	ABC_A
# InterPro	IPR027417	P-loop_NTPase
# InterPro	IPR030365	ABCA1
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Disease	H00159	[Inherited metabolic disease; Nervous system disease] Tangier disease
# KEGG_Disease	H00930	[Inherited metabolic disease] Hypoalphalipoproteinemia
# KEGG_Pathway	ko02010	ABC transporters
# KEGG_Pathway	ko04975	Fat digestion and absorption
# MIM	205400	phenotype
# MIM	600046	gene+phenotype
# MIM	604091	phenotype
# Organism	ABCA1_HUMAN	Homo sapiens (Human)
# Orphanet	31150	Tangier disease
# Orphanet	425	Apolipoprotein A-I deficiency
# PANTHER	PTHR19229	PTHR19229; 6
# PANTHER	PTHR19229:SF34	PTHR19229:SF34; 6
# POLYMORPHISM	Genetic variations in ABCA1 define the high density lipoprotein cholesterol level quantitative trait locus 13 (HDLCQ13) [MIM:600046]. {ECO	0000269|PubMed:18354102}. 
# PROSITE	PS00211	ABC_TRANSPORTER_1
# PROSITE	PS50893	ABC_TRANSPORTER_2; 2
# PTM	ABCA1_HUMAN	Palmitoylation by DHHC8 is essential for membrane localization. {ECO 0000269|PubMed 19556522}. 
# PTM	ABCA1_HUMAN	Phosphorylation on Ser-2054 regulates phospholipid efflux. {ECO 0000269|PubMed 12196520}. 
# Pfam	PF00005	ABC_tran; 2
# Proteomes	UP000005640	Chromosome 9
# Reactome	R-HSA-194223	HDL-mediated lipid transport
# Reactome	R-HSA-1989781	PPARA activates gene expression
# RecName	ABCA1_HUMAN	ATP-binding cassette sub-family A member 1
# RefSeq	NP_005493	NM_005502.3
# SEQUENCE CAUTION	Sequence=AAD49849.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA10005.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCA family. {ECO	0000305}. 
# SIMILARITY	Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA; 2
# SUBCELLULAR LOCATION	ABCA1_HUMAN	Membrane {ECO 0000269|PubMed 19258317, ECO 0000269|PubMed 19556522}; Multi-pass membrane protein {ECO 0000269|PubMed 19258317, ECO 0000269|PubMed 19556522}. 
# SUBUNIT	Interacts with MEGF10. {ECO:0000269|PubMed	17205124}. 
# SUPFAM	SSF52540	SSF52540; 2
# TCDB	3.A.1.211.14	the atp-binding cassette (abc) superfamily
# TISSUE SPECIFICITY	ABCA1_HUMAN	Widely expressed, but most abundant in macrophages. 
# UCSC	uc004bcl	human
# WEB RESOURCE	ABCA1_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=O95477";
# WEB RESOURCE	ABCA1_HUMAN	Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http //shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=ABCA1"; 
# eggNOG	COG1131	LUCA
# eggNOG	KOG0059	Eukaryota
BLAST	swissprot:ABCA1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCA1_HUMAN
BioCyc	ZFISH:ENSG00000165029-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000165029-MONOMER
COXPRESdb	19	http://coxpresdb.jp/data/gene/19.shtml
DIP	DIP-29211N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29211N
DOI	10.1006/bbrc.1999.0406	http://dx.doi.org/10.1006/bbrc.1999.0406
DOI	10.1006/bbrc.2001.6219	http://dx.doi.org/10.1006/bbrc.2001.6219
DOI	10.1006/geno.2000.6467	http://dx.doi.org/10.1006/geno.2000.6467
DOI	10.1007/s00439-003-0943-3	http://dx.doi.org/10.1007/s00439-003-0943-3
DOI	10.1007/s100380200044	http://dx.doi.org/10.1007/s100380200044
DOI	10.1007/s100380200051	http://dx.doi.org/10.1007/s100380200051
DOI	10.1016/S0021-9150(00)00587-6	http://dx.doi.org/10.1016/S0021-9150(00)00587-6
DOI	10.1016/S0021-9150(00)00722-X	http://dx.doi.org/10.1016/S0021-9150(00)00722-X
DOI	10.1016/S0021-9150(02)00106-5	http://dx.doi.org/10.1016/S0021-9150(02)00106-5
DOI	10.1016/S0140-6736(99)07026-9	http://dx.doi.org/10.1016/S0140-6736(99)07026-9
DOI	10.1016/S0925-4439(01)00053-9	http://dx.doi.org/10.1016/S0925-4439(01)00053-9
DOI	10.1016/S0925-4439(01)00058-8	http://dx.doi.org/10.1016/S0925-4439(01)00058-8
DOI	10.1016/S0925-4439(02)00066-2	http://dx.doi.org/10.1016/S0925-4439(02)00066-2
DOI	10.1016/j.atherosclerosis.2003.11.009	http://dx.doi.org/10.1016/j.atherosclerosis.2003.11.009
DOI	10.1016/j.atherosclerosis.2004.02.019	http://dx.doi.org/10.1016/j.atherosclerosis.2004.02.019
DOI	10.1016/j.bbadis.2004.01.007	http://dx.doi.org/10.1016/j.bbadis.2004.01.007
DOI	10.1016/j.jacc.2005.06.066	http://dx.doi.org/10.1016/j.jacc.2005.06.066
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/11905	http://dx.doi.org/10.1038/11905
DOI	10.1038/11914	http://dx.doi.org/10.1038/11914
DOI	10.1038/11921	http://dx.doi.org/10.1038/11921
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
DOI	10.1038/nature19057	http://dx.doi.org/10.1038/nature19057
DOI	10.1056/NEJMoa0706728	http://dx.doi.org/10.1056/NEJMoa0706728
DOI	10.1073/pnas.97.14.7987	http://dx.doi.org/10.1073/pnas.97.14.7987
DOI	10.1074/jbc.M100218200	http://dx.doi.org/10.1074/jbc.M100218200
DOI	10.1074/jbc.M204923200	http://dx.doi.org/10.1074/jbc.M204923200
DOI	10.1074/jbc.M900580200	http://dx.doi.org/10.1074/jbc.M900580200
DOI	10.1093/hmg/ddg314	http://dx.doi.org/10.1093/hmg/ddg314
DOI	10.1126/science.1099870	http://dx.doi.org/10.1126/science.1099870
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1136/jmg.40.3.163	http://dx.doi.org/10.1136/jmg.40.3.163
DOI	10.1161/01.ATV.0000078520.89539.77	http://dx.doi.org/10.1161/01.ATV.0000078520.89539.77
DOI	10.1161/01.ATV.20.8.1983	http://dx.doi.org/10.1161/01.ATV.20.8.1983
DOI	10.1161/01.CIR.103.9.1198	http://dx.doi.org/10.1161/01.CIR.103.9.1198
DOI	10.1161/01.RES.0000102957.84247.8F	http://dx.doi.org/10.1161/01.RES.0000102957.84247.8F
DOI	10.1161/CIRCRESAHA.108.193011	http://dx.doi.org/10.1161/CIRCRESAHA.108.193011
DOI	10.1172/JCI10727	http://dx.doi.org/10.1172/JCI10727
DOI	10.1172/JCI200420361	http://dx.doi.org/10.1172/JCI200420361
DOI	10.1182/blood-2004-05-2056	http://dx.doi.org/10.1182/blood-2004-05-2056
DOI	10.1194/jlr.D400038-JLR200	http://dx.doi.org/10.1194/jlr.D400038-JLR200
DOI	10.1371/journal.pone.0000120	http://dx.doi.org/10.1371/journal.pone.0000120
DrugBank	DB00171	http://www.drugbank.ca/drugs/DB00171
DrugBank	DB01016	http://www.drugbank.ca/drugs/DB01016
DrugBank	DB01599	http://www.drugbank.ca/drugs/DB01599
EMBL	AB055982	http://www.ebi.ac.uk/ena/data/view/AB055982
EMBL	AF165281	http://www.ebi.ac.uk/ena/data/view/AF165281
EMBL	AF165282	http://www.ebi.ac.uk/ena/data/view/AF165282
EMBL	AF165283	http://www.ebi.ac.uk/ena/data/view/AF165283
EMBL	AF165284	http://www.ebi.ac.uk/ena/data/view/AF165284
EMBL	AF165285	http://www.ebi.ac.uk/ena/data/view/AF165285
EMBL	AF165286	http://www.ebi.ac.uk/ena/data/view/AF165286
EMBL	AF165287	http://www.ebi.ac.uk/ena/data/view/AF165287
EMBL	AF165288	http://www.ebi.ac.uk/ena/data/view/AF165288
EMBL	AF165289	http://www.ebi.ac.uk/ena/data/view/AF165289
EMBL	AF165290	http://www.ebi.ac.uk/ena/data/view/AF165290
EMBL	AF165291	http://www.ebi.ac.uk/ena/data/view/AF165291
EMBL	AF165292	http://www.ebi.ac.uk/ena/data/view/AF165292
EMBL	AF165293	http://www.ebi.ac.uk/ena/data/view/AF165293
EMBL	AF165294	http://www.ebi.ac.uk/ena/data/view/AF165294
EMBL	AF165295	http://www.ebi.ac.uk/ena/data/view/AF165295
EMBL	AF165296	http://www.ebi.ac.uk/ena/data/view/AF165296
EMBL	AF165297	http://www.ebi.ac.uk/ena/data/view/AF165297
EMBL	AF165298	http://www.ebi.ac.uk/ena/data/view/AF165298
EMBL	AF165299	http://www.ebi.ac.uk/ena/data/view/AF165299
EMBL	AF165300	http://www.ebi.ac.uk/ena/data/view/AF165300
EMBL	AF165301	http://www.ebi.ac.uk/ena/data/view/AF165301
EMBL	AF165302	http://www.ebi.ac.uk/ena/data/view/AF165302
EMBL	AF165303	http://www.ebi.ac.uk/ena/data/view/AF165303
EMBL	AF165304	http://www.ebi.ac.uk/ena/data/view/AF165304
EMBL	AF165305	http://www.ebi.ac.uk/ena/data/view/AF165305
EMBL	AF165306	http://www.ebi.ac.uk/ena/data/view/AF165306
EMBL	AF165307	http://www.ebi.ac.uk/ena/data/view/AF165307
EMBL	AF165308	http://www.ebi.ac.uk/ena/data/view/AF165308
EMBL	AF165309	http://www.ebi.ac.uk/ena/data/view/AF165309
EMBL	AF165310	http://www.ebi.ac.uk/ena/data/view/AF165310
EMBL	AF275948	http://www.ebi.ac.uk/ena/data/view/AF275948
EMBL	AF285167	http://www.ebi.ac.uk/ena/data/view/AF285167
EMBL	AF287262	http://www.ebi.ac.uk/ena/data/view/AF287262
EMBL	AJ012376	http://www.ebi.ac.uk/ena/data/view/AJ012376
EMBL	AL353685	http://www.ebi.ac.uk/ena/data/view/AL353685
EMBL	AL353685	http://www.ebi.ac.uk/ena/data/view/AL353685
EMBL	AL359846	http://www.ebi.ac.uk/ena/data/view/AL359846
EMBL	AL359846	http://www.ebi.ac.uk/ena/data/view/AL359846
Ensembl	ENST00000374736	http://www.ensembl.org/id/ENST00000374736
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0009897	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009897
GO_component	GO:0030139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030139
GO_component	GO:0034364	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034364
GO_component	GO:0045121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045121
GO_component	GO:0045335	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045335
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_function	GO:0005102	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005102
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0005543	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005543
GO_function	GO:0005548	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005548
GO_function	GO:0008509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008509
GO_function	GO:0015485	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015485
GO_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GO_function	GO:0017127	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017127
GO_function	GO:0019905	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019905
GO_function	GO:0031267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031267
GO_function	GO:0034185	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034185
GO_function	GO:0034186	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034186
GO_function	GO:0034188	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034188
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GO_function	GO:0051117	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051117
GO_function	GO:0090554	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090554
GO_function	GO:0090556	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090556
GO_process	GO:0002790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002790
GO_process	GO:0006497	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006497
GO_process	GO:0006911	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006911
GO_process	GO:0007040	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007040
GO_process	GO:0007186	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007186
GO_process	GO:0007584	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007584
GO_process	GO:0008203	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008203
GO_process	GO:0010745	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010745
GO_process	GO:0010875	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010875
GO_process	GO:0010887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010887
GO_process	GO:0016197	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016197
GO_process	GO:0030819	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030819
GO_process	GO:0032367	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032367
GO_process	GO:0032489	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032489
GO_process	GO:0033344	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033344
GO_process	GO:0033700	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033700
GO_process	GO:0034380	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034380
GO_process	GO:0034616	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034616
GO_process	GO:0042157	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042157
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0042632	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042632
GO_process	GO:0043691	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043691
GO_process	GO:0045332	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045332
GO_process	GO:0050702	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050702
GO_process	GO:0055091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055091
GO_process	GO:0055098	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055098
GO_process	GO:0060155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060155
GO_process	GO:0071222	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071222
GO_process	GO:0071300	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071300
GO_process	GO:0071397	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071397
GO_process	GO:0090107	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090107
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
GOslim_process	GO:0065003	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0065003
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCA1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCA1
GeneID	19	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19
GeneTree	ENSGT00760000118965	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118965
HGNC	HGNC:29	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:29
HOVERGEN	HBG050436	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050436&db=HOVERGEN
HPA	CAB069889	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB069889
HPA	HPA057283	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA057283
InParanoid	O95477	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O95477
IntAct	O95477	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O95477*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR026082	http://www.ebi.ac.uk/interpro/entry/IPR026082
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
InterPro	IPR030365	http://www.ebi.ac.uk/interpro/entry/IPR030365
Jabion	19	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=19
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Disease	H00159	http://www.genome.jp/dbget-bin/www_bget?H00159
KEGG_Disease	H00930	http://www.genome.jp/dbget-bin/www_bget?H00930
KEGG_Gene	hsa:19	http://www.genome.jp/dbget-bin/www_bget?hsa:19
KEGG_Orthology	KO:K05641	http://www.genome.jp/dbget-bin/www_bget?KO:K05641
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
KEGG_Pathway	ko04975	http://www.genome.jp/kegg-bin/show_pathway?ko04975
MIM	205400	http://www.ncbi.nlm.nih.gov/omim/205400
MIM	600046	http://www.ncbi.nlm.nih.gov/omim/600046
MIM	604091	http://www.ncbi.nlm.nih.gov/omim/604091
MINT	MINT-239561	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-239561
OMA	KRMSEIC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KRMSEIC
Orphanet	31150	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=31150
Orphanet	425	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=425
OrthoDB	EOG091G007E	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G007E
PANTHER	PTHR19229	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19229
PANTHER	PTHR19229:SF34	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19229:SF34
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PSORT	swissprot:ABCA1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCA1_HUMAN
PSORT-B	swissprot:ABCA1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCA1_HUMAN
PSORT2	swissprot:ABCA1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCA1_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
PharmGKB	PA24373	http://www.pharmgkb.org/do/serve?objId=PA24373&objCls=Gene
Phobius	swissprot:ABCA1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCA1_HUMAN
PhylomeDB	O95477	http://phylomedb.org/?seqid=O95477
ProteinModelPortal	O95477	http://www.proteinmodelportal.org/query/uniprot/O95477
PubMed	10092505	http://www.ncbi.nlm.nih.gov/pubmed/10092505
PubMed	10431236	http://www.ncbi.nlm.nih.gov/pubmed/10431236
PubMed	10431237	http://www.ncbi.nlm.nih.gov/pubmed/10431237
PubMed	10431238	http://www.ncbi.nlm.nih.gov/pubmed/10431238
PubMed	10533863	http://www.ncbi.nlm.nih.gov/pubmed/10533863
PubMed	10706591	http://www.ncbi.nlm.nih.gov/pubmed/10706591
PubMed	10884428	http://www.ncbi.nlm.nih.gov/pubmed/10884428
PubMed	10938021	http://www.ncbi.nlm.nih.gov/pubmed/10938021
PubMed	11086027	http://www.ncbi.nlm.nih.gov/pubmed/11086027
PubMed	11238261	http://www.ncbi.nlm.nih.gov/pubmed/11238261
PubMed	11257260	http://www.ncbi.nlm.nih.gov/pubmed/11257260
PubMed	11257261	http://www.ncbi.nlm.nih.gov/pubmed/11257261
PubMed	11279031	http://www.ncbi.nlm.nih.gov/pubmed/11279031
PubMed	11352567	http://www.ncbi.nlm.nih.gov/pubmed/11352567
PubMed	11476961	http://www.ncbi.nlm.nih.gov/pubmed/11476961
PubMed	11476965	http://www.ncbi.nlm.nih.gov/pubmed/11476965
PubMed	11785958	http://www.ncbi.nlm.nih.gov/pubmed/11785958
PubMed	12009425	http://www.ncbi.nlm.nih.gov/pubmed/12009425
PubMed	12032171	http://www.ncbi.nlm.nih.gov/pubmed/12032171
PubMed	12111371	http://www.ncbi.nlm.nih.gov/pubmed/12111371
PubMed	12111381	http://www.ncbi.nlm.nih.gov/pubmed/12111381
PubMed	12196520	http://www.ncbi.nlm.nih.gov/pubmed/12196520
PubMed	12204794	http://www.ncbi.nlm.nih.gov/pubmed/12204794
PubMed	12407001	http://www.ncbi.nlm.nih.gov/pubmed/12407001
PubMed	12624133	http://www.ncbi.nlm.nih.gov/pubmed/12624133
PubMed	12709788	http://www.ncbi.nlm.nih.gov/pubmed/12709788
PubMed	12763760	http://www.ncbi.nlm.nih.gov/pubmed/12763760
PubMed	12966036	http://www.ncbi.nlm.nih.gov/pubmed/12966036
PubMed	14576201	http://www.ncbi.nlm.nih.gov/pubmed/14576201
PubMed	15019541	http://www.ncbi.nlm.nih.gov/pubmed/15019541
PubMed	15158913	http://www.ncbi.nlm.nih.gov/pubmed/15158913
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
PubMed	15262183	http://www.ncbi.nlm.nih.gov/pubmed/15262183
PubMed	15297675	http://www.ncbi.nlm.nih.gov/pubmed/15297675
PubMed	15520867	http://www.ncbi.nlm.nih.gov/pubmed/15520867
PubMed	15722566	http://www.ncbi.nlm.nih.gov/pubmed/15722566
PubMed	15790791	http://www.ncbi.nlm.nih.gov/pubmed/15790791
PubMed	16226177	http://www.ncbi.nlm.nih.gov/pubmed/16226177
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	17205124	http://www.ncbi.nlm.nih.gov/pubmed/17205124
PubMed	18354102	http://www.ncbi.nlm.nih.gov/pubmed/18354102
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	19258317	http://www.ncbi.nlm.nih.gov/pubmed/19258317
PubMed	19556522	http://www.ncbi.nlm.nih.gov/pubmed/19556522
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	27535533	http://www.ncbi.nlm.nih.gov/pubmed/27535533
Reactome	R-HSA-194223	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-194223
Reactome	R-HSA-1989781	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1989781
RefSeq	NP_005493	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005493
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	O95477	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O95477
STRING	9606.ENSP00000363868	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000363868&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TCDB	3.A.1.211.14	http://www.tcdb.org/search/result.php?tc=3.A.1.211.14
UCSC	uc004bcl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004bcl&org=rat
UniGene	Hs.659274	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.659274
UniProtKB	ABCA1_HUMAN	http://www.uniprot.org/uniprot/ABCA1_HUMAN
UniProtKB-AC	O95477	http://www.uniprot.org/uniprot/O95477
charge	swissprot:ABCA1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCA1_HUMAN
eggNOG	COG1131	http://eggnogapi.embl.de/nog_data/html/tree/COG1131
eggNOG	KOG0059	http://eggnogapi.embl.de/nog_data/html/tree/KOG0059
epestfind	swissprot:ABCA1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCA1_HUMAN
garnier	swissprot:ABCA1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCA1_HUMAN
helixturnhelix	swissprot:ABCA1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCA1_HUMAN
hmoment	swissprot:ABCA1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCA1_HUMAN
iep	swissprot:ABCA1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCA1_HUMAN
inforesidue	swissprot:ABCA1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCA1_HUMAN
neXtProt	NX_O95477	http://www.nextprot.org/db/entry/NX_O95477
octanol	swissprot:ABCA1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCA1_HUMAN
pepcoil	swissprot:ABCA1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCA1_HUMAN
pepdigest	swissprot:ABCA1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCA1_HUMAN
pepinfo	swissprot:ABCA1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCA1_HUMAN
pepnet	swissprot:ABCA1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCA1_HUMAN
pepstats	swissprot:ABCA1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCA1_HUMAN
pepwheel	swissprot:ABCA1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCA1_HUMAN
pepwindow	swissprot:ABCA1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCA1_HUMAN
sigcleave	swissprot:ABCA1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCA1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CMC1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75746-1; Sequence=Displayed; Name=2; IsoId=O75746-2; Sequence=VSP_054469; Note=No experimental confirmation available.; 
# AltName	CMC1_HUMAN	Mitochondrial aspartate glutamate carrier 1
# AltName	CMC1_HUMAN	Solute carrier family 25 member 12
# BioGrid	114164	32
# CCDS	CCDS33327	-. [O75746-1]
# ChiTaRS	SLC25A12	human
# DISEASE	CMC1_HUMAN	Epileptic encephalopathy, early infantile, 39 (EIEE39) [MIM 612949]  A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. EIEE39 is characterized by global hypomyelination of the central nervous system, with the gray matter appearing relatively unaffected. Inheritance is autosomal recessive. {ECO 0000269|PubMed 19641205, ECO 0000269|PubMed 24515575}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00128	L-Aspartic Acid
# Ensembl	ENST00000422440	ENSP00000388658; ENSG00000115840. [O75746-1]
# ExpressionAtlas	O75746	baseline and differential
# FUNCTION	CMC1_HUMAN	Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle. {ECO 0000269|PubMed 11566871}. 
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0043209	myelin sheath; IEA:Ensembl.
# GO_function	GO:0005313	L-glutamate transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0005509	calcium ion binding; IDA:UniProtKB.
# GO_function	GO:0015172	acidic amino acid transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015183	L-aspartate transmembrane transporter activity; IDA:UniProtKB.
# GO_process	GO:0006094	gluconeogenesis; TAS:Reactome.
# GO_process	GO:0015810	aspartate transport; IDA:UniProtKB.
# GO_process	GO:0015813	L-glutamate transport; IDA:UniProtKB.
# GO_process	GO:0043490	malate-aspartate shuttle; IDA:UniProtKB.
# GO_process	GO:0051592	response to calcium ion; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0005975	carbohydrate metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0044281	small molecule metabolic process
# Gene3D	1.10.238.10	-; 2.
# Gene3D	1.50.40.10	-; 1.
# Genevisible	O75746	HS
# HGNC	HGNC:10982	SLC25A12
# IntAct	O75746	26
# InterPro	IPR002048	EF_hand_dom
# InterPro	IPR002067	Mit_carrier
# InterPro	IPR011992	EF-hand-dom_pair
# InterPro	IPR018108	Mitochondrial_sb/sol_carrier
# InterPro	IPR018247	EF_Hand_1_Ca_BS
# InterPro	IPR023395	Mt_carrier_dom
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H01305	[Developmental disorder; Nervous system disease] Global cerebral hypomyelination
# MIM	603667	gene
# MIM	612949	phenotype
# MISCELLANEOUS	CMC1_HUMAN	Binds calcium. 
# Organism	CMC1_HUMAN	Homo sapiens (Human)
# Orphanet	353217	Epileptic encephalopathy with global cerebral demyelination
# PDB	4P5X	X-ray; 2.26 A; A=2-311
# PDB	4P60	X-ray; 2.40 A; A/B=2-311
# PRINTS	PR00926	MITOCARRIER
# PROSITE	PS00018	EF_HAND_1
# PROSITE	PS50222	EF_HAND_2; 2
# PROSITE	PS50920	SOLCAR; 3
# Pfam	PF00153	Mito_carr; 3
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-1268020	Mitochondrial protein import
# Reactome	R-HSA-70263	Gluconeogenesis
# RecName	CMC1_HUMAN	Calcium-binding mitochondrial carrier protein Aralar1
# RefSeq	NP_003696	NM_003705.4. [O75746-1]
# SIMILARITY	Belongs to the mitochondrial carrier (TC 2.A.29) family. {ECO	0000305}. 
# SIMILARITY	Contains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule	PRU00282}.
# SIMILARITY	Contains 4 EF-hand domains. {ECO:0000255|PROSITE- ProRule	PRU00448}. 
# SMART	SM00054	EFh; 3
# SUBCELLULAR LOCATION	CMC1_HUMAN	Mitochondrion inner membrane {ECO 0000269|PubMed 9722566}; Multi-pass membrane protein {ECO 0000269|PubMed 9722566}. 
# SUPFAM	SSF103506	SSF103506
# SUPFAM	SSF47473	SSF47473; 2
# TCDB	2.A.29.14	the mitochondrial carrier (mc) family
# TISSUE SPECIFICITY	CMC1_HUMAN	High levels in heart and skeletal muscle, low in brain and very low in kidney. {ECO 0000269|PubMed 10369257, ECO 0000269|PubMed 9722566}. 
# UCSC	uc002uhh	human. [O75746-1]
# eggNOG	ENOG410XNRM	LUCA
# eggNOG	KOG0751	Eukaryota
BLAST	swissprot:CMC1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CMC1_HUMAN
BioCyc	ZFISH:ENSG00000115840-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000115840-MONOMER
COXPRESdb	8604	http://coxpresdb.jp/data/gene/8604.shtml
CleanEx	HS_SLC25A12	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC25A12
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1007/8904_2013_287	http://dx.doi.org/10.1007/8904_2013_287
DOI	10.1038/9667	http://dx.doi.org/10.1038/9667
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1056/NEJMoa0900591	http://dx.doi.org/10.1056/NEJMoa0900591
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1074/jbc.273.36.23327	http://dx.doi.org/10.1074/jbc.273.36.23327
DOI	10.1093/emboj/20.18.5060	http://dx.doi.org/10.1093/emboj/20.18.5060
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DrugBank	DB00128	http://www.drugbank.ca/drugs/DB00128
EMBL	AC015976	http://www.ebi.ac.uk/ena/data/view/AC015976
EMBL	AC068039	http://www.ebi.ac.uk/ena/data/view/AC068039
EMBL	AC114745	http://www.ebi.ac.uk/ena/data/view/AC114745
EMBL	AJ496568	http://www.ebi.ac.uk/ena/data/view/AJ496568
EMBL	AK091071	http://www.ebi.ac.uk/ena/data/view/AK091071
EMBL	BC016932	http://www.ebi.ac.uk/ena/data/view/BC016932
EMBL	CH471058	http://www.ebi.ac.uk/ena/data/view/CH471058
EMBL	Y14494	http://www.ebi.ac.uk/ena/data/view/Y14494
Ensembl	ENST00000422440	http://www.ensembl.org/id/ENST00000422440
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0043209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043209
GO_function	GO:0005313	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005313
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0015172	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015172
GO_function	GO:0015183	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015183
GO_process	GO:0006094	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006094
GO_process	GO:0015810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015810
GO_process	GO:0015813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015813
GO_process	GO:0043490	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043490
GO_process	GO:0051592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051592
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
Gene3D	1.10.238.10	http://www.cathdb.info/version/latest/superfamily/1.10.238.10
Gene3D	1.50.40.10	http://www.cathdb.info/version/latest/superfamily/1.50.40.10
GeneCards	SLC25A12	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC25A12
GeneID	8604	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8604
GeneTree	ENSGT00530000062944	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062944
H-InvDB	HIX0002590	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0002590
HGNC	HGNC:10982	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10982
HOGENOM	HOG000180633	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000180633&db=HOGENOM6
HOVERGEN	HBG005350	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG005350&db=HOVERGEN
HPA	HPA035333	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035333
HPA	HPA035334	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035334
InParanoid	O75746	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O75746
IntAct	O75746	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O75746*
InterPro	IPR002048	http://www.ebi.ac.uk/interpro/entry/IPR002048
InterPro	IPR002067	http://www.ebi.ac.uk/interpro/entry/IPR002067
InterPro	IPR011992	http://www.ebi.ac.uk/interpro/entry/IPR011992
InterPro	IPR018108	http://www.ebi.ac.uk/interpro/entry/IPR018108
InterPro	IPR018247	http://www.ebi.ac.uk/interpro/entry/IPR018247
InterPro	IPR023395	http://www.ebi.ac.uk/interpro/entry/IPR023395
Jabion	8604	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=8604
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H01305	http://www.genome.jp/dbget-bin/www_bget?H01305
KEGG_Gene	hsa:8604	http://www.genome.jp/dbget-bin/www_bget?hsa:8604
KEGG_Orthology	KO:K15105	http://www.genome.jp/dbget-bin/www_bget?KO:K15105
MIM	603667	http://www.ncbi.nlm.nih.gov/omim/603667
MIM	612949	http://www.ncbi.nlm.nih.gov/omim/612949
OMA	DGYNHPL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DGYNHPL
Orphanet	353217	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=353217
OrthoDB	EOG091G08GT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08GT
PDB	4P5X	http://www.ebi.ac.uk/pdbe-srv/view/entry/4P5X
PDB	4P60	http://www.ebi.ac.uk/pdbe-srv/view/entry/4P60
PDBsum	4P5X	http://www.ebi.ac.uk/pdbsum/4P5X
PDBsum	4P60	http://www.ebi.ac.uk/pdbsum/4P60
PRINTS	PR00926	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00926
PROSITE	PS00018	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00018
PROSITE	PS50222	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50222
PROSITE	PS50920	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50920
PSORT	swissprot:CMC1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CMC1_HUMAN
PSORT-B	swissprot:CMC1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CMC1_HUMAN
PSORT2	swissprot:CMC1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CMC1_HUMAN
Pfam	PF00153	http://pfam.xfam.org/family/PF00153
PharmGKB	PA35858	http://www.pharmgkb.org/do/serve?objId=PA35858&objCls=Gene
Phobius	swissprot:CMC1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CMC1_HUMAN
PhylomeDB	O75746	http://phylomedb.org/?seqid=O75746
ProteinModelPortal	O75746	http://www.proteinmodelportal.org/query/uniprot/O75746
PubMed	10369257	http://www.ncbi.nlm.nih.gov/pubmed/10369257
PubMed	11566871	http://www.ncbi.nlm.nih.gov/pubmed/11566871
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	19641205	http://www.ncbi.nlm.nih.gov/pubmed/19641205
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	24515575	http://www.ncbi.nlm.nih.gov/pubmed/24515575
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	9722566	http://www.ncbi.nlm.nih.gov/pubmed/9722566
Reactome	R-HSA-1268020	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1268020
Reactome	R-HSA-70263	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-70263
RefSeq	NP_003696	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003696
SMART	SM00054	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00054
SMR	O75746	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O75746
STRING	9606.ENSP00000388658	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000388658&targetmode=cogs
SUPFAM	SSF103506	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103506
SUPFAM	SSF47473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47473
TCDB	2.A.29.14	http://www.tcdb.org/search/result.php?tc=2.A.29.14
UCSC	uc002uhh	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002uhh&org=rat
UniGene	Hs.470608	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.470608
UniProtKB	CMC1_HUMAN	http://www.uniprot.org/uniprot/CMC1_HUMAN
UniProtKB-AC	O75746	http://www.uniprot.org/uniprot/O75746
charge	swissprot:CMC1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CMC1_HUMAN
eggNOG	ENOG410XNRM	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNRM
eggNOG	KOG0751	http://eggnogapi.embl.de/nog_data/html/tree/KOG0751
epestfind	swissprot:CMC1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CMC1_HUMAN
garnier	swissprot:CMC1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CMC1_HUMAN
helixturnhelix	swissprot:CMC1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CMC1_HUMAN
hmoment	swissprot:CMC1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CMC1_HUMAN
iep	swissprot:CMC1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CMC1_HUMAN
inforesidue	swissprot:CMC1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CMC1_HUMAN
neXtProt	NX_O75746	http://www.nextprot.org/db/entry/NX_O75746
octanol	swissprot:CMC1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CMC1_HUMAN
pepcoil	swissprot:CMC1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CMC1_HUMAN
pepdigest	swissprot:CMC1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CMC1_HUMAN
pepinfo	swissprot:CMC1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CMC1_HUMAN
pepnet	swissprot:CMC1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CMC1_HUMAN
pepstats	swissprot:CMC1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CMC1_HUMAN
pepwheel	swissprot:CMC1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CMC1_HUMAN
pepwindow	swissprot:CMC1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CMC1_HUMAN
sigcleave	swissprot:CMC1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CMC1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=2; Name=Alpha; IsoId=P10415-1; Sequence=Displayed; Name=Beta; IsoId=P10415-2; Sequence=VSP_000512; Note=Ref.1 (AAA51814) sequence is in conflict in position: 199	L->S. {ECO:0000305}; 
# BioGrid	107068	98
# CCDS	CCDS11981	-. [P10415-1]
# CCDS	CCDS45882	-. [P10415-2]
# ChiTaRS	BCL2	human
# DISEASE	BCL2_HUMAN	Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions. {ECO 0000269|PubMed 2875799, ECO 0000269|PubMed 3285301}. 
# DOMAIN	BCL2_HUMAN	BH1 and BH2 domains are required for the interaction with BAX and for anti-apoptotic activity. {ECO 0000269|PubMed 8183370}. 
# DOMAIN	BCL2_HUMAN	The BH4 motif is required for anti-apoptotic activity and for interaction with RAF1 and EGLN3. 
# DOMAIN	BCL2_HUMAN	The loop between motifs BH4 and BH3 is required for the interaction with NLRP1. {ECO 0000269|PubMed 17418785}. 
# DrugBank	DB01050	Ibuprofen
# DrugBank	DB01229	Paclitaxel
# DrugBank	DB01248	Docetaxel
# DrugBank	DB01367	Rasagiline
# Ensembl	ENST00000333681	ENSP00000329623; ENSG00000171791. [P10415-1]
# Ensembl	ENST00000398117	ENSP00000381185; ENSG00000171791. [P10415-1]
# Ensembl	ENST00000589955	ENSP00000466417; ENSG00000171791. [P10415-2]
# ExpressionAtlas	P10415	baseline and differential
# FUNCTION	BCL2_HUMAN	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed 17418785). {ECO 0000269|PubMed 17418785, ECO 0000269|PubMed 18570871}. 
# GO_component	GO:0005634	nucleus; IDA:MGI.
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005741	mitochondrial outer membrane; IDA:UniProtKB.
# GO_component	GO:0005783	endoplasmic reticulum; IDA:UniProtKB.
# GO_component	GO:0005789	endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005829	cytosol; IEA:Ensembl.
# GO_component	GO:0016020	membrane; IDA:MGI.
# GO_component	GO:0031965	nuclear membrane; IDA:UniProtKB.
# GO_component	GO:0043209	myelin sheath; IEA:Ensembl.
# GO_component	GO:0046930	pore complex; IDA:BHF-UCL.
# GO_function	GO:0002020	protease binding; IDA:UniProtKB.
# GO_function	GO:0015267	channel activity; IDA:BHF-UCL.
# GO_function	GO:0016248	channel inhibitor activity; IDA:BHF-UCL.
# GO_function	GO:0031625	ubiquitin protein ligase binding; IPI:UniProtKB.
# GO_function	GO:0042803	protein homodimerization activity; IPI:UniProtKB.
# GO_function	GO:0043565	sequence-specific DNA binding; IDA:MGI.
# GO_function	GO:0046982	protein heterodimerization activity; IPI:UniProtKB.
# GO_function	GO:0051434	BH3 domain binding; IPI:UniProtKB.
# GO_process	GO:0000209	protein polyubiquitination; IDA:MGI.
# GO_process	GO:0001503	ossification; IEA:Ensembl.
# GO_process	GO:0001541	ovarian follicle development; IEA:Ensembl.
# GO_process	GO:0001656	metanephros development; IEA:Ensembl.
# GO_process	GO:0001658	branching involved in ureteric bud morphogenesis; IEA:Ensembl.
# GO_process	GO:0001662	behavioral fear response; IEA:Ensembl.
# GO_process	GO:0001782	B cell homeostasis; IEA:Ensembl.
# GO_process	GO:0001836	release of cytochrome c from mitochondria; NAS:UniProtKB.
# GO_process	GO:0001952	regulation of cell-matrix adhesion; IEA:Ensembl.
# GO_process	GO:0002320	lymphoid progenitor cell differentiation; IEA:Ensembl.
# GO_process	GO:0002326	B cell lineage commitment; IEA:Ensembl.
# GO_process	GO:0002931	response to ischemia; IEA:Ensembl.
# GO_process	GO:0003014	renal system process; IEA:Ensembl.
# GO_process	GO:0006470	protein dephosphorylation; IEA:Ensembl.
# GO_process	GO:0006582	melanin metabolic process; IEA:Ensembl.
# GO_process	GO:0006808	regulation of nitrogen utilization; IEA:Ensembl.
# GO_process	GO:0006915	apoptotic process; IDA:MGI.
# GO_process	GO:0006959	humoral immune response; TAS:UniProtKB.
# GO_process	GO:0006974	cellular response to DNA damage stimulus; IMP:UniProtKB.
# GO_process	GO:0007015	actin filament organization; IEA:Ensembl.
# GO_process	GO:0007409	axonogenesis; IEA:Ensembl.
# GO_process	GO:0007565	female pregnancy; NAS:UniProtKB.
# GO_process	GO:0007569	cell aging; IEA:Ensembl.
# GO_process	GO:0008584	male gonad development; IEA:Ensembl.
# GO_process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors; IDA:MGI.
# GO_process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage; IBA:GO_Central.
# GO_process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress; IEA:Ensembl.
# GO_process	GO:0009314	response to radiation; NAS:UniProtKB.
# GO_process	GO:0009636	response to toxic substance; IDA:HGNC.
# GO_process	GO:0009791	post-embryonic development; IEA:Ensembl.
# GO_process	GO:0010039	response to iron ion; IDA:UniProtKB.
# GO_process	GO:0010224	response to UV-B; IEA:Ensembl.
# GO_process	GO:0010332	response to gamma radiation; IEA:Ensembl.
# GO_process	GO:0010468	regulation of gene expression; IEA:Ensembl.
# GO_process	GO:0010507	negative regulation of autophagy; TAS:UniProtKB.
# GO_process	GO:0010523	negative regulation of calcium ion transport into cytosol; IEA:Ensembl.
# GO_process	GO:0010559	regulation of glycoprotein biosynthetic process; IEA:Ensembl.
# GO_process	GO:0014031	mesenchymal cell development; IEA:Ensembl.
# GO_process	GO:0014042	positive regulation of neuron maturation; IEA:Ensembl.
# GO_process	GO:0014911	positive regulation of smooth muscle cell migration; IEA:Ensembl.
# GO_process	GO:0016049	cell growth; IEA:Ensembl.
# GO_process	GO:0018105	peptidyl-serine phosphorylation; IEA:Ensembl.
# GO_process	GO:0018107	peptidyl-threonine phosphorylation; IEA:Ensembl.
# GO_process	GO:0021747	cochlear nucleus development; IEA:Ensembl.
# GO_process	GO:0022612	gland morphogenesis; IEA:Ensembl.
# GO_process	GO:0022898	regulation of transmembrane transporter activity; IDA:BHF-UCL.
# GO_process	GO:0030279	negative regulation of ossification; IEA:Ensembl.
# GO_process	GO:0030307	positive regulation of cell growth; IDA:MGI.
# GO_process	GO:0030308	negative regulation of cell growth; IEA:Ensembl.
# GO_process	GO:0030318	melanocyte differentiation; IEA:Ensembl.
# GO_process	GO:0030336	negative regulation of cell migration; IEA:Ensembl.
# GO_process	GO:0030890	positive regulation of B cell proliferation; IMP:UniProtKB.
# GO_process	GO:0031069	hair follicle morphogenesis; IEA:Ensembl.
# GO_process	GO:0031103	axon regeneration; IEA:Ensembl.
# GO_process	GO:0031647	regulation of protein stability; IEA:Ensembl.
# GO_process	GO:0032469	endoplasmic reticulum calcium ion homeostasis; TAS:UniProtKB.
# GO_process	GO:0032835	glomerulus development; IEA:Ensembl.
# GO_process	GO:0032848	negative regulation of cellular pH reduction; IDA:UniProtKB.
# GO_process	GO:0033033	negative regulation of myeloid cell apoptotic process; IEA:Ensembl.
# GO_process	GO:0033077	T cell differentiation in thymus; IEA:Ensembl.
# GO_process	GO:0033138	positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
# GO_process	GO:0033689	negative regulation of osteoblast proliferation; IEA:Ensembl.
# GO_process	GO:0034097	response to cytokine; IDA:MGI.
# GO_process	GO:0035094	response to nicotine; IDA:UniProtKB.
# GO_process	GO:0035265	organ growth; IEA:Ensembl.
# GO_process	GO:0040018	positive regulation of multicellular organism growth; IEA:Ensembl.
# GO_process	GO:0042100	B cell proliferation; IDA:MGI.
# GO_process	GO:0042149	cellular response to glucose starvation; IEA:Ensembl.
# GO_process	GO:0042493	response to drug; IMP:UniProtKB.
# GO_process	GO:0042542	response to hydrogen peroxide; IEA:Ensembl.
# GO_process	GO:0043029	T cell homeostasis; IEA:Ensembl.
# GO_process	GO:0043066	negative regulation of apoptotic process; IDA:UniProtKB.
# GO_process	GO:0043085	positive regulation of catalytic activity; IEA:Ensembl.
# GO_process	GO:0043375	CD8-positive, alpha-beta T cell lineage commitment; IEA:Ensembl.
# GO_process	GO:0043496	regulation of protein homodimerization activity; IDA:UniProtKB.
# GO_process	GO:0043497	regulation of protein heterodimerization activity; IDA:UniProtKB.
# GO_process	GO:0043524	negative regulation of neuron apoptotic process; IDA:MGI.
# GO_process	GO:0043583	ear development; IEA:Ensembl.
# GO_process	GO:0045069	regulation of viral genome replication; IEA:Ensembl.
# GO_process	GO:0045636	positive regulation of melanocyte differentiation; IEA:Ensembl.
# GO_process	GO:0046671	negative regulation of retinal cell programmed cell death; IEA:Ensembl.
# GO_process	GO:0046902	regulation of mitochondrial membrane permeability; ISS:HGNC.
# GO_process	GO:0048041	focal adhesion assembly; IEA:Ensembl.
# GO_process	GO:0048536	spleen development; IEA:Ensembl.
# GO_process	GO:0048538	thymus development; IEA:Ensembl.
# GO_process	GO:0048546	digestive tract morphogenesis; IEA:Ensembl.
# GO_process	GO:0048599	oocyte development; IEA:Ensembl.
# GO_process	GO:0048743	positive regulation of skeletal muscle fiber development; IEA:Ensembl.
# GO_process	GO:0048753	pigment granule organization; IEA:Ensembl.
# GO_process	GO:0048873	homeostasis of number of cells within a tissue; IEA:Ensembl.
# GO_process	GO:0050853	B cell receptor signaling pathway; IMP:UniProtKB.
# GO_process	GO:0051384	response to glucocorticoid; IEA:Ensembl.
# GO_process	GO:0051402	neuron apoptotic process; TAS:HGNC.
# GO_process	GO:0051607	defense response to virus; IDA:UniProtKB.
# GO_process	GO:0051881	regulation of mitochondrial membrane potential; ISS:HGNC.
# GO_process	GO:0051902	negative regulation of mitochondrial depolarization; TAS:UniProtKB.
# GO_process	GO:0051924	regulation of calcium ion transport; IDA:MGI.
# GO_process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IDA:MGI.
# GO_process	GO:0071310	cellular response to organic substance; IEA:Ensembl.
# GO_process	GO:0071456	cellular response to hypoxia; IEA:Ensembl.
# GO_process	GO:0072593	reactive oxygen species metabolic process; IEA:Ensembl.
# GO_process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
# GO_process	GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; TAS:Reactome.
# GO_process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle; IEA:Ensembl.
# GO_process	GO:2000378	negative regulation of reactive oxygen species metabolic process; IEA:Ensembl.
# GO_process	GO:2000811	negative regulation of anoikis; IMP:UniProtKB.
# GO_process	GO:2001234	negative regulation of apoptotic signaling pathway; IMP:UniProtKB.
# GO_process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IGI:MGI.
# GO_process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway; IDA:UniProtKB.
# GO_process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0003677	DNA binding
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007005	mitochondrion organization
# GOslim_process	GO:0007155	cell adhesion
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007568	aging
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0008219	cell death
# GOslim_process	GO:0008283	cell proliferation
# GOslim_process	GO:0019748	secondary metabolic process
# GOslim_process	GO:0022607	cellular component assembly
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0034330	cell junction organization
# GOslim_process	GO:0040007	growth
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0061024	membrane organization
# Genevisible	P10415	HS
# HGNC	HGNC:990	BCL2
# INTERACTION	BCL2_HUMAN	Self; NbExp=3; IntAct=EBI-77694, EBI-77694; Q9C0C7 AMBRA1; NbExp=10; IntAct=EBI-77694, EBI-2512975; Q92934 BAD; NbExp=5; IntAct=EBI-77694, EBI-700771; Q61337 Bad (xeno); NbExp=6; IntAct=EBI-77694, EBI-400328; Q16611 BAK1; NbExp=3; IntAct=EBI-77694, EBI-519866; Q07812 BAX; NbExp=11; IntAct=EBI-77694, EBI-516580; Q9BXH1 BBC3; NbExp=5; IntAct=EBI-77694, EBI-519884; P51572 BCAP31; NbExp=2; IntAct=EBI-77694, EBI-77683; O43521 BCL2L11; NbExp=8; IntAct=EBI-77694, EBI-526406; O43521-1 BCL2L11; NbExp=3; IntAct=EBI-77694, EBI-526416; O43521-2 BCL2L11; NbExp=4; IntAct=EBI-77694, EBI-526420; Q9NYF8 BCLAF1; NbExp=2; IntAct=EBI-77694, EBI-437804; Q14457 BECN1; NbExp=16; IntAct=EBI-77694, EBI-949378; P55957 BID; NbExp=8; IntAct=EBI-77694, EBI-519672; Q13323 BIK; NbExp=5; IntAct=EBI-77694, EBI-700794; Q91ZE9 Bmf (xeno); NbExp=2; IntAct=EBI-77694, EBI-708032; O60238 BNIP3L; NbExp=2; IntAct=EBI-77694, EBI-849893; P38398 BRCA1; NbExp=6; IntAct=EBI-77694, EBI-349905; Q5S007 LRRK2; NbExp=2; IntAct=EBI-4370304, EBI-5323863; O15151 MDM4; NbExp=4; IntAct=EBI-77694, EBI-398437; Q96HR8 NAF1; NbExp=2; IntAct=EBI-77694, EBI-2515597; Q9C000 NLRP1; NbExp=12; IntAct=EBI-77694, EBI-1220518; P22736 NR4A1; NbExp=7; IntAct=EBI-77694, EBI-721550; Q13794 PMAIP1; NbExp=3; IntAct=EBI-4370304, EBI-707392; O15304 SIVA1; NbExp=2; IntAct=EBI-77694, EBI-520756; P04637 TP53; NbExp=5; IntAct=EBI-77694, EBI-366083; Q13625 TP53BP2; NbExp=13; IntAct=EBI-77694, EBI-77642; 
# IntAct	P10415	47
# InterPro	IPR002475	Bcl2-like
# InterPro	IPR003093	Bcl2_BH4
# InterPro	IPR004725	Bcl2/BclX
# InterPro	IPR013278	Apop_reg_Bcl2
# InterPro	IPR020717	Bcl2_BH1_motif_CS
# InterPro	IPR020726	Bcl2_BH2_motif_CS
# InterPro	IPR020728	Bcl2_BH3_motif_CS
# InterPro	IPR020731	Bcl2_BH4_motif_CS
# InterPro	IPR026298	Blc2_fam
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Disease	H00005	[Cancer] Chronic lymphocytic leukemia (CLL)
# KEGG_Disease	H00013	[Cancer] Small cell lung cancer
# KEGG_Disease	H00018	[Cancer] Gastric cancer
# KEGG_Disease	H00028	[Cancer] Choriocarcinoma
# KEGG_Disease	H00030	[Cancer] Cervical cancer
# KEGG_Disease	H00041	[Cancer] Kaposi's sarcoma
# KEGG_Disease	H00054	[Cancer] Nasopharyngeal cancer
# KEGG_Disease	H01613	[Cancer] Follicular lymphoma
# KEGG_Pathway	ko04064	NF-kappa B signaling pathway
# KEGG_Pathway	ko04066	HIF-1 signaling pathway
# KEGG_Pathway	ko04141	Protein processing in endoplasmic reticulum
# KEGG_Pathway	ko04151	PI3K-Akt signaling pathway
# KEGG_Pathway	ko04210	Apoptosis
# KEGG_Pathway	ko04510	Focal adhesion
# KEGG_Pathway	ko04722	Neurotrophin signaling pathway
# KEGG_Pathway	ko04725	Cholinergic synapse
# KEGG_Pathway	ko05014	Amyotrophic lateral sclerosis (ALS)
# KEGG_Pathway	ko05145	Toxoplasmosis
# KEGG_Pathway	ko05152	Tuberculosis
# KEGG_Pathway	ko05161	Hepatitis B
# KEGG_Pathway	ko05169	Epstein-Barr virus infection
# KEGG_Pathway	ko05200	Pathways in cancer
# KEGG_Pathway	ko05210	Colorectal cancer
# KEGG_Pathway	ko05215	Prostate cancer
# KEGG_Pathway	ko05222	Small cell lung cancer
# MIM	151430	gene+phenotype
# Organism	BCL2_HUMAN	Homo sapiens (Human)
# Orphanet	545	Follicular lymphoma
# Orphanet	98839	Intravascular large B-cell lymphoma
# PANTHER	PTHR11256	PTHR11256
# PANTHER	PTHR11256:SF11	PTHR11256:SF11
# PDB	1G5M	NMR; -; A=1-34, A=92-207
# PDB	1GJH	NMR; -; A=1-34, A=92-207
# PDB	1YSW	NMR; -; A=3-33, A=92-206
# PDB	2O21	NMR; -; A=3-34, A=92-207
# PDB	2O22	NMR; -; A=3-34, A=92-207
# PDB	2O2F	NMR; -; A=8-31, A=92-204
# PDB	2W3L	X-ray; 2.10 A; A/B=92-206
# PDB	2XA0	X-ray; 2.70 A; A/B=1-207
# PDB	4AQ3	X-ray; 2.40 A; A/B/C/D/E/F=1-33, A/B/C/D/E/F=92-207
# PDB	4IEH	X-ray; 2.10 A; A=1-34, A=92-207
# PDB	4LVT	X-ray; 2.05 A; A/B=1-34, A/B=92-207
# PDB	4LXD	X-ray; 1.90 A; A=1-34, A=92-207
# PDB	4MAN	X-ray; 2.07 A; A/B=1-34, A/B=92-207
# PDB	5AGW	X-ray; 2.69 A; A/B=1-34, A/B=92-207
# PDB	5AGX	X-ray; 2.24 A; A/B=1-34, A/B=92-207
# PDB	5FCG	X-ray; 2.10 A; A=1-207
# PIR	B29409	TVHUB1
# PIR	C37332	TVHUA1
# PRINTS	PR01862	BCL2FAMILY
# PRINTS	PR01863	APOPREGBCL2
# PROSITE	PS01080	BH1
# PROSITE	PS01258	BH2
# PROSITE	PS01259	BH3
# PROSITE	PS01260	BH4_1
# PROSITE	PS50062	BCL2_FAMILY
# PROSITE	PS50063	BH4_2
# PTM	BCL2_HUMAN	Monoubiquitinated by PARK2, leading to increase its stability. Ubiquitinated by SCF(FBXO10), leading to its degradation by the proteasome. {ECO 0000269|PubMed 20889974, ECO 0000269|PubMed 23431138}. 
# PTM	BCL2_HUMAN	Phosphorylation/dephosphorylation on Ser-70 regulates anti- apoptotic activity. Growth factor-stimulated phosphorylation on Ser-70 by PKC is required for the anti-apoptosis activity and occurs during the G2/M phase of the cell cycle. In the absence of growth factors, BCL2 appears to be phosphorylated by other protein kinases such as ERKs and stress-activated kinases. Phosphorylated by MAPK8/JNK1 at Thr-69, Ser-70 and Ser-87, wich stimulates starvation-induced autophagy. Dephosphorylated by protein phosphatase 2A (PP2A) (By similarity). {ECO 0000250}. 
# PTM	BCL2_HUMAN	Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity, causes the release of cytochrome c into the cytosol promoting further caspase activity. {ECO 0000269|PubMed 9395403}. 
# Pfam	PF00452	Bcl-2
# Pfam	PF02180	BH4
# Proteomes	UP000005640	Chromosome 18
# Reactome	R-HSA-111447	Activation of BAD and translocation to mitochondria
# Reactome	R-HSA-111453	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
# Reactome	R-HSA-844455	The NLRP1 inflammasome
# RecName	BCL2_HUMAN	Apoptosis regulator Bcl-2
# RefSeq	NP_000624	NM_000633.2. [P10415-1]
# RefSeq	NP_000648	NM_000657.2. [P10415-2]
# SIMILARITY	Belongs to the Bcl-2 family. {ECO	0000305}. 
# SMART	SM00265	BH4
# SUBCELLULAR LOCATION	BCL2_HUMAN	Mitochondrion outer membrane {ECO 0000269|PubMed 2250705}; Single-pass membrane protein {ECO 0000269|PubMed 2250705}. Nucleus membrane {ECO 0000269|PubMed 2250705}; Single-pass membrane protein {ECO 0000269|PubMed 2250705}. Endoplasmic reticulum membrane {ECO 0000269|PubMed 2250705}; Single-pass membrane protein {ECO 0000269|PubMed 2250705}. 
# SUBUNIT	BCL2_HUMAN	Forms homodimers, and heterodimers with BAX, BAD, BAK and Bcl-X(L). Heterodimerization with BAX requires intact BH1 and BH2 motifs, and is necessary for anti-apoptotic activity (PubMed 8183370). Interacts with EI24 (By similarity). Also interacts with APAF1, BBC3, BCL2L1, BNIPL, MRPL41 and TP53BP2. Binding to FKBP8 seems to target BCL2 to the mitochondria and probably interferes with the binding of BCL2 to its targets. Interacts with BAG1 in an ATP-dependent manner. Interacts with RAF1 (the 'Ser-338' and 'Ser-339' phosphorylated form). Interacts (via the BH4 domain) with EGLN3; the interaction prevents the formation of the BAX-BCL2 complex and inhibits the anti-apoptotic activity of BCL2. Interacts with G0S2; this interaction also prevents the formation of the anti-apoptotic BAX-BCL2 complex. Interacts with BOP. Interacts with the SCF(FBXO10) complex. Interacts (via the loop between motifs BH4 and BH3) with NLRP1 (via LRR repeats), but not with NLRP2, NLRP3, NLRP4, PYCARD, nor MEFV (PubMed 17418785). {ECO 0000250, ECO 0000269|PubMed 11463391, ECO 0000269|PubMed 12901880, ECO 0000269|PubMed 15547950, ECO 0000269|PubMed 15733859, ECO 0000269|PubMed 15849194, ECO 0000269|PubMed 17090549, ECO 0000269|PubMed 17418785, ECO 0000269|PubMed 19228691, ECO 0000269|PubMed 19706769, ECO 0000269|PubMed 20849813, ECO 0000269|PubMed 23055042, ECO 0000269|PubMed 23431138, ECO 0000269|PubMed 8183370, ECO 0000269|PubMed 8668206, ECO 0000269|PubMed 9305631}. 
# TIGRFAMs	TIGR00865	bcl-2
# TISSUE SPECIFICITY	BCL2_HUMAN	Expressed in a variety of tissues. 
# UCSC	uc002lit	human. [P10415-1]
# WEB RESOURCE	BCL2_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/BCL2ID49.html"; 
# WEB RESOURCE	BCL2_HUMAN	Name=NIEHS-SNPs; URL="http //egp.gs.washington.edu/data/bcl2/"; 
# WEB RESOURCE	BCL2_HUMAN	Name=Wikipedia; Note=Bcl-2 entry; URL="https //en.wikipedia.org/wiki/Bcl-2";
# eggNOG	ENOG41123S0	LUCA
# eggNOG	KOG4728	Eukaryota
BLAST	swissprot:BCL2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:BCL2_HUMAN
BioCyc	ZFISH:ENSG00000171791-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000171791-MONOMER
COXPRESdb	596	http://coxpresdb.jp/data/gene/596.shtml
CleanEx	HS_BCL2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_BCL2
DIP	DIP-1043N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-1043N
DOI	10.1002/jcb.20292	http://dx.doi.org/10.1002/jcb.20292
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1007/s13238-012-2069-7	http://dx.doi.org/10.1007/s13238-012-2069-7
DOI	10.1016/0092-8674(86)90362-4	http://dx.doi.org/10.1016/0092-8674(86)90362-4
DOI	10.1016/S0006-291X(03)01387-1	http://dx.doi.org/10.1016/S0006-291X(03)01387-1
DOI	10.1016/S1097-2765(01)00213-1	http://dx.doi.org/10.1016/S1097-2765(01)00213-1
DOI	10.1016/j.bbrc.2010.09.037	http://dx.doi.org/10.1016/j.bbrc.2010.09.037
DOI	10.1016/j.cell.2007.01.045	http://dx.doi.org/10.1016/j.cell.2007.01.045
DOI	10.1016/j.febslet.2005.01.053	http://dx.doi.org/10.1016/j.febslet.2005.01.053
DOI	10.1016/j.molcel.2008.06.001	http://dx.doi.org/10.1016/j.molcel.2008.06.001
DOI	10.1021/jm061152t	http://dx.doi.org/10.1021/jm061152t
DOI	10.1038/348334a0	http://dx.doi.org/10.1038/348334a0
DOI	10.1038/369321a0	http://dx.doi.org/10.1038/369321a0
DOI	10.1038/nature03579	http://dx.doi.org/10.1038/nature03579
DOI	10.1038/nature03983	http://dx.doi.org/10.1038/nature03983
DOI	10.1038/sj/leu/2402090	http://dx.doi.org/10.1038/sj/leu/2402090
DOI	10.1073/pnas.041619798	http://dx.doi.org/10.1073/pnas.041619798
DOI	10.1073/pnas.1217271110	http://dx.doi.org/10.1073/pnas.1217271110
DOI	10.1073/pnas.83.14.5214	http://dx.doi.org/10.1073/pnas.83.14.5214
DOI	10.1074/jbc.M110.101469	http://dx.doi.org/10.1074/jbc.M110.101469
DOI	10.1074/jbc.M413374200	http://dx.doi.org/10.1074/jbc.M413374200
DOI	10.1074/jbc.M606181200	http://dx.doi.org/10.1074/jbc.M606181200
DOI	10.1074/jbc.M808750200	http://dx.doi.org/10.1074/jbc.M808750200
DOI	10.1093/emboj/16.16.4887	http://dx.doi.org/10.1093/emboj/16.16.4887
DOI	10.1093/nar/20.16.4187	http://dx.doi.org/10.1093/nar/20.16.4187
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.278.5345.1966	http://dx.doi.org/10.1126/science.278.5345.1966
DOI	10.1128/MCB.16.7.3884	http://dx.doi.org/10.1128/MCB.16.7.3884
DOI	10.1128/MCB.19.12.8469	http://dx.doi.org/10.1128/MCB.19.12.8469
DOI	10.1158/0008-5472.CAN-09-0128	http://dx.doi.org/10.1158/0008-5472.CAN-09-0128
DisProt	DP00297	http://www.disprot.org/protein.php?id=DP00297
DrugBank	DB01050	http://www.drugbank.ca/drugs/DB01050
DrugBank	DB01229	http://www.drugbank.ca/drugs/DB01229
DrugBank	DB01248	http://www.drugbank.ca/drugs/DB01248
DrugBank	DB01367	http://www.drugbank.ca/drugs/DB01367
EMBL	AC021803	http://www.ebi.ac.uk/ena/data/view/AC021803
EMBL	AC022726	http://www.ebi.ac.uk/ena/data/view/AC022726
EMBL	AY220759	http://www.ebi.ac.uk/ena/data/view/AY220759
EMBL	BC027258	http://www.ebi.ac.uk/ena/data/view/BC027258
EMBL	CH471096	http://www.ebi.ac.uk/ena/data/view/CH471096
EMBL	M13994	http://www.ebi.ac.uk/ena/data/view/M13994
EMBL	M13995	http://www.ebi.ac.uk/ena/data/view/M13995
EMBL	M14745	http://www.ebi.ac.uk/ena/data/view/M14745
EMBL	S72602	http://www.ebi.ac.uk/ena/data/view/S72602
EMBL	X06487	http://www.ebi.ac.uk/ena/data/view/X06487
Ensembl	ENST00000333681	http://www.ensembl.org/id/ENST00000333681
Ensembl	ENST00000398117	http://www.ensembl.org/id/ENST00000398117
Ensembl	ENST00000589955	http://www.ensembl.org/id/ENST00000589955
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005741	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005741
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0031965	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031965
GO_component	GO:0043209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043209
GO_component	GO:0046930	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046930
GO_function	GO:0002020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002020
GO_function	GO:0015267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015267
GO_function	GO:0016248	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016248
GO_function	GO:0031625	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031625
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_function	GO:0043565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565
GO_function	GO:0046982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046982
GO_function	GO:0051434	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051434
GO_process	GO:0000209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000209
GO_process	GO:0001503	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001503
GO_process	GO:0001541	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001541
GO_process	GO:0001656	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001656
GO_process	GO:0001658	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001658
GO_process	GO:0001662	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001662
GO_process	GO:0001782	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001782
GO_process	GO:0001836	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001836
GO_process	GO:0001952	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001952
GO_process	GO:0002320	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002320
GO_process	GO:0002326	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002326
GO_process	GO:0002931	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002931
GO_process	GO:0003014	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003014
GO_process	GO:0006470	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006470
GO_process	GO:0006582	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006582
GO_process	GO:0006808	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006808
GO_process	GO:0006915	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006915
GO_process	GO:0006959	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006959
GO_process	GO:0006974	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974
GO_process	GO:0007015	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007015
GO_process	GO:0007409	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007409
GO_process	GO:0007565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007565
GO_process	GO:0007569	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007569
GO_process	GO:0008584	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008584
GO_process	GO:0008625	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008625
GO_process	GO:0008630	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008630
GO_process	GO:0008631	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008631
GO_process	GO:0009314	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009314
GO_process	GO:0009636	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009636
GO_process	GO:0009791	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009791
GO_process	GO:0010039	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010039
GO_process	GO:0010224	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010224
GO_process	GO:0010332	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010332
GO_process	GO:0010468	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010468
GO_process	GO:0010507	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010507
GO_process	GO:0010523	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010523
GO_process	GO:0010559	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010559
GO_process	GO:0014031	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014031
GO_process	GO:0014042	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014042
GO_process	GO:0014911	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014911
GO_process	GO:0016049	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016049
GO_process	GO:0018105	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018105
GO_process	GO:0018107	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018107
GO_process	GO:0021747	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021747
GO_process	GO:0022612	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022612
GO_process	GO:0022898	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022898
GO_process	GO:0030279	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030279
GO_process	GO:0030307	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030307
GO_process	GO:0030308	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030308
GO_process	GO:0030318	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030318
GO_process	GO:0030336	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030336
GO_process	GO:0030890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030890
GO_process	GO:0031069	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031069
GO_process	GO:0031103	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031103
GO_process	GO:0031647	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031647
GO_process	GO:0032469	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032469
GO_process	GO:0032835	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032835
GO_process	GO:0032848	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032848
GO_process	GO:0033033	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033033
GO_process	GO:0033077	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033077
GO_process	GO:0033138	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033138
GO_process	GO:0033689	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033689
GO_process	GO:0034097	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034097
GO_process	GO:0035094	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035094
GO_process	GO:0035265	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035265
GO_process	GO:0040018	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040018
GO_process	GO:0042100	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042100
GO_process	GO:0042149	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042149
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0042542	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042542
GO_process	GO:0043029	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043029
GO_process	GO:0043066	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043066
GO_process	GO:0043085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043085
GO_process	GO:0043375	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043375
GO_process	GO:0043496	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043496
GO_process	GO:0043497	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043497
GO_process	GO:0043524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043524
GO_process	GO:0043583	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043583
GO_process	GO:0045069	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045069
GO_process	GO:0045636	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045636
GO_process	GO:0046671	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046671
GO_process	GO:0046902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046902
GO_process	GO:0048041	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048041
GO_process	GO:0048536	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048536
GO_process	GO:0048538	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048538
GO_process	GO:0048546	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048546
GO_process	GO:0048599	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048599
GO_process	GO:0048743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048743
GO_process	GO:0048753	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048753
GO_process	GO:0048873	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048873
GO_process	GO:0050853	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050853
GO_process	GO:0051384	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051384
GO_process	GO:0051402	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051402
GO_process	GO:0051607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051607
GO_process	GO:0051881	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051881
GO_process	GO:0051902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051902
GO_process	GO:0051924	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051924
GO_process	GO:0070059	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070059
GO_process	GO:0071310	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071310
GO_process	GO:0071456	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071456
GO_process	GO:0072593	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072593
GO_process	GO:0097192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097192
GO_process	GO:1900740	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900740
GO_process	GO:2000134	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000134
GO_process	GO:2000378	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000378
GO_process	GO:2000811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000811
GO_process	GO:2001234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001234
GO_process	GO:2001240	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001240
GO_process	GO:2001243	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001243
GO_process	GO:2001244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001244
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0003677	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007005
GOslim_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007568	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007568
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0008219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219
GOslim_process	GO:0008283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008283
GOslim_process	GO:0019748	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019748
GOslim_process	GO:0022607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0034330	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034330
GOslim_process	GO:0040007	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040007
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
GeneCards	BCL2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=BCL2
GeneID	596	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=596
GeneTree	ENSGT00530000062935	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062935
HGNC	HGNC:990	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:990
HOGENOM	HOG000056452	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000056452&db=HOGENOM6
HOVERGEN	HBG004472	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004472&db=HOVERGEN
HPA	CAB000003	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB000003
InParanoid	P10415	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P10415
IntAct	P10415	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P10415*
InterPro	IPR002475	http://www.ebi.ac.uk/interpro/entry/IPR002475
InterPro	IPR003093	http://www.ebi.ac.uk/interpro/entry/IPR003093
InterPro	IPR004725	http://www.ebi.ac.uk/interpro/entry/IPR004725
InterPro	IPR013278	http://www.ebi.ac.uk/interpro/entry/IPR013278
InterPro	IPR020717	http://www.ebi.ac.uk/interpro/entry/IPR020717
InterPro	IPR020726	http://www.ebi.ac.uk/interpro/entry/IPR020726
InterPro	IPR020728	http://www.ebi.ac.uk/interpro/entry/IPR020728
InterPro	IPR020731	http://www.ebi.ac.uk/interpro/entry/IPR020731
InterPro	IPR026298	http://www.ebi.ac.uk/interpro/entry/IPR026298
Jabion	596	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=596
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Disease	H00005	http://www.genome.jp/dbget-bin/www_bget?H00005
KEGG_Disease	H00013	http://www.genome.jp/dbget-bin/www_bget?H00013
KEGG_Disease	H00018	http://www.genome.jp/dbget-bin/www_bget?H00018
KEGG_Disease	H00028	http://www.genome.jp/dbget-bin/www_bget?H00028
KEGG_Disease	H00030	http://www.genome.jp/dbget-bin/www_bget?H00030
KEGG_Disease	H00041	http://www.genome.jp/dbget-bin/www_bget?H00041
KEGG_Disease	H00054	http://www.genome.jp/dbget-bin/www_bget?H00054
KEGG_Disease	H01613	http://www.genome.jp/dbget-bin/www_bget?H01613
KEGG_Gene	hsa:596	http://www.genome.jp/dbget-bin/www_bget?hsa:596
KEGG_Orthology	KO:K02161	http://www.genome.jp/dbget-bin/www_bget?KO:K02161
KEGG_Pathway	ko04064	http://www.genome.jp/kegg-bin/show_pathway?ko04064
KEGG_Pathway	ko04066	http://www.genome.jp/kegg-bin/show_pathway?ko04066
KEGG_Pathway	ko04141	http://www.genome.jp/kegg-bin/show_pathway?ko04141
KEGG_Pathway	ko04151	http://www.genome.jp/kegg-bin/show_pathway?ko04151
KEGG_Pathway	ko04210	http://www.genome.jp/kegg-bin/show_pathway?ko04210
KEGG_Pathway	ko04510	http://www.genome.jp/kegg-bin/show_pathway?ko04510
KEGG_Pathway	ko04722	http://www.genome.jp/kegg-bin/show_pathway?ko04722
KEGG_Pathway	ko04725	http://www.genome.jp/kegg-bin/show_pathway?ko04725
KEGG_Pathway	ko05014	http://www.genome.jp/kegg-bin/show_pathway?ko05014
KEGG_Pathway	ko05145	http://www.genome.jp/kegg-bin/show_pathway?ko05145
KEGG_Pathway	ko05152	http://www.genome.jp/kegg-bin/show_pathway?ko05152
KEGG_Pathway	ko05161	http://www.genome.jp/kegg-bin/show_pathway?ko05161
KEGG_Pathway	ko05169	http://www.genome.jp/kegg-bin/show_pathway?ko05169
KEGG_Pathway	ko05200	http://www.genome.jp/kegg-bin/show_pathway?ko05200
KEGG_Pathway	ko05210	http://www.genome.jp/kegg-bin/show_pathway?ko05210
KEGG_Pathway	ko05215	http://www.genome.jp/kegg-bin/show_pathway?ko05215
KEGG_Pathway	ko05222	http://www.genome.jp/kegg-bin/show_pathway?ko05222
MIM	151430	http://www.ncbi.nlm.nih.gov/omim/151430
MINT	MINT-87089	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-87089
OMA	IVLKYIH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IVLKYIH
Orphanet	545	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=545
Orphanet	98839	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98839
OrthoDB	EOG091G0OCU	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0OCU
PANTHER	PTHR11256	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11256
PANTHER	PTHR11256:SF11	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11256:SF11
PDB	1G5M	http://www.ebi.ac.uk/pdbe-srv/view/entry/1G5M
PDB	1GJH	http://www.ebi.ac.uk/pdbe-srv/view/entry/1GJH
PDB	1YSW	http://www.ebi.ac.uk/pdbe-srv/view/entry/1YSW
PDB	2O21	http://www.ebi.ac.uk/pdbe-srv/view/entry/2O21
PDB	2O22	http://www.ebi.ac.uk/pdbe-srv/view/entry/2O22
PDB	2O2F	http://www.ebi.ac.uk/pdbe-srv/view/entry/2O2F
PDB	2W3L	http://www.ebi.ac.uk/pdbe-srv/view/entry/2W3L
PDB	2XA0	http://www.ebi.ac.uk/pdbe-srv/view/entry/2XA0
PDB	4AQ3	http://www.ebi.ac.uk/pdbe-srv/view/entry/4AQ3
PDB	4IEH	http://www.ebi.ac.uk/pdbe-srv/view/entry/4IEH
PDB	4LVT	http://www.ebi.ac.uk/pdbe-srv/view/entry/4LVT
PDB	4LXD	http://www.ebi.ac.uk/pdbe-srv/view/entry/4LXD
PDB	4MAN	http://www.ebi.ac.uk/pdbe-srv/view/entry/4MAN
PDB	5AGW	http://www.ebi.ac.uk/pdbe-srv/view/entry/5AGW
PDB	5AGX	http://www.ebi.ac.uk/pdbe-srv/view/entry/5AGX
PDB	5FCG	http://www.ebi.ac.uk/pdbe-srv/view/entry/5FCG
PDBsum	1G5M	http://www.ebi.ac.uk/pdbsum/1G5M
PDBsum	1GJH	http://www.ebi.ac.uk/pdbsum/1GJH
PDBsum	1YSW	http://www.ebi.ac.uk/pdbsum/1YSW
PDBsum	2O21	http://www.ebi.ac.uk/pdbsum/2O21
PDBsum	2O22	http://www.ebi.ac.uk/pdbsum/2O22
PDBsum	2O2F	http://www.ebi.ac.uk/pdbsum/2O2F
PDBsum	2W3L	http://www.ebi.ac.uk/pdbsum/2W3L
PDBsum	2XA0	http://www.ebi.ac.uk/pdbsum/2XA0
PDBsum	4AQ3	http://www.ebi.ac.uk/pdbsum/4AQ3
PDBsum	4IEH	http://www.ebi.ac.uk/pdbsum/4IEH
PDBsum	4LVT	http://www.ebi.ac.uk/pdbsum/4LVT
PDBsum	4LXD	http://www.ebi.ac.uk/pdbsum/4LXD
PDBsum	4MAN	http://www.ebi.ac.uk/pdbsum/4MAN
PDBsum	5AGW	http://www.ebi.ac.uk/pdbsum/5AGW
PDBsum	5AGX	http://www.ebi.ac.uk/pdbsum/5AGX
PDBsum	5FCG	http://www.ebi.ac.uk/pdbsum/5FCG
PRINTS	PR01862	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01862
PRINTS	PR01863	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01863
PROSITE	PS01080	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01080
PROSITE	PS01258	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01258
PROSITE	PS01259	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01259
PROSITE	PS01260	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01260
PROSITE	PS50062	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50062
PROSITE	PS50063	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50063
PSORT	swissprot:BCL2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:BCL2_HUMAN
PSORT-B	swissprot:BCL2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:BCL2_HUMAN
PSORT2	swissprot:BCL2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:BCL2_HUMAN
Pfam	PF00452	http://pfam.xfam.org/family/PF00452
Pfam	PF02180	http://pfam.xfam.org/family/PF02180
PharmGKB	PA25302	http://www.pharmgkb.org/do/serve?objId=PA25302&objCls=Gene
Phobius	swissprot:BCL2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:BCL2_HUMAN
PhylomeDB	P10415	http://phylomedb.org/?seqid=P10415
ProteinModelPortal	P10415	http://www.proteinmodelportal.org/query/uniprot/P10415
PubMed	10567572	http://www.ncbi.nlm.nih.gov/pubmed/10567572
PubMed	11248023	http://www.ncbi.nlm.nih.gov/pubmed/11248023
PubMed	11368354	http://www.ncbi.nlm.nih.gov/pubmed/11368354
PubMed	11463391	http://www.ncbi.nlm.nih.gov/pubmed/11463391
PubMed	12901880	http://www.ncbi.nlm.nih.gov/pubmed/12901880
PubMed	1339299	http://www.ncbi.nlm.nih.gov/pubmed/1339299
PubMed	1508712	http://www.ncbi.nlm.nih.gov/pubmed/1508712
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15547950	http://www.ncbi.nlm.nih.gov/pubmed/15547950
PubMed	15733859	http://www.ncbi.nlm.nih.gov/pubmed/15733859
PubMed	15849194	http://www.ncbi.nlm.nih.gov/pubmed/15849194
PubMed	15902208	http://www.ncbi.nlm.nih.gov/pubmed/15902208
PubMed	16177791	http://www.ncbi.nlm.nih.gov/pubmed/16177791
PubMed	17090549	http://www.ncbi.nlm.nih.gov/pubmed/17090549
PubMed	17256834	http://www.ncbi.nlm.nih.gov/pubmed/17256834
PubMed	17418785	http://www.ncbi.nlm.nih.gov/pubmed/17418785
PubMed	18570871	http://www.ncbi.nlm.nih.gov/pubmed/18570871
PubMed	19228691	http://www.ncbi.nlm.nih.gov/pubmed/19228691
PubMed	19706769	http://www.ncbi.nlm.nih.gov/pubmed/19706769
PubMed	20849813	http://www.ncbi.nlm.nih.gov/pubmed/20849813
PubMed	20889974	http://www.ncbi.nlm.nih.gov/pubmed/20889974
PubMed	2250705	http://www.ncbi.nlm.nih.gov/pubmed/2250705
PubMed	23055042	http://www.ncbi.nlm.nih.gov/pubmed/23055042
PubMed	23431138	http://www.ncbi.nlm.nih.gov/pubmed/23431138
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	2834197	http://www.ncbi.nlm.nih.gov/pubmed/2834197
PubMed	2875799	http://www.ncbi.nlm.nih.gov/pubmed/2875799
PubMed	3285301	http://www.ncbi.nlm.nih.gov/pubmed/3285301
PubMed	3523487	http://www.ncbi.nlm.nih.gov/pubmed/3523487
PubMed	8183370	http://www.ncbi.nlm.nih.gov/pubmed/8183370
PubMed	8668206	http://www.ncbi.nlm.nih.gov/pubmed/8668206
PubMed	9305631	http://www.ncbi.nlm.nih.gov/pubmed/9305631
PubMed	9395403	http://www.ncbi.nlm.nih.gov/pubmed/9395403
Reactome	R-HSA-111447	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-111447
Reactome	R-HSA-111453	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-111453
Reactome	R-HSA-844455	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-844455
RefSeq	NP_000624	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000624
RefSeq	NP_000648	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000648
SMART	SM00265	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00265
SMR	P10415	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P10415
STRING	9606.ENSP00000329623	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000329623&targetmode=cogs
TIGRFAMs	TIGR00865	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00865
UCSC	uc002lit	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002lit&org=rat
UniGene	Hs.150749	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.150749
UniProtKB	BCL2_HUMAN	http://www.uniprot.org/uniprot/BCL2_HUMAN
UniProtKB-AC	P10415	http://www.uniprot.org/uniprot/P10415
charge	swissprot:BCL2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:BCL2_HUMAN
eggNOG	ENOG41123S0	http://eggnogapi.embl.de/nog_data/html/tree/ENOG41123S0
eggNOG	KOG4728	http://eggnogapi.embl.de/nog_data/html/tree/KOG4728
epestfind	swissprot:BCL2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:BCL2_HUMAN
garnier	swissprot:BCL2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:BCL2_HUMAN
helixturnhelix	swissprot:BCL2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:BCL2_HUMAN
hmoment	swissprot:BCL2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:BCL2_HUMAN
iep	swissprot:BCL2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:BCL2_HUMAN
inforesidue	swissprot:BCL2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:BCL2_HUMAN
neXtProt	NX_P10415	http://www.nextprot.org/db/entry/NX_P10415
octanol	swissprot:BCL2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:BCL2_HUMAN
pepcoil	swissprot:BCL2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:BCL2_HUMAN
pepdigest	swissprot:BCL2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:BCL2_HUMAN
pepinfo	swissprot:BCL2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:BCL2_HUMAN
pepnet	swissprot:BCL2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:BCL2_HUMAN
pepstats	swissprot:BCL2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:BCL2_HUMAN
pepwheel	swissprot:BCL2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:BCL2_HUMAN
pepwindow	swissprot:BCL2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:BCL2_HUMAN
sigcleave	swissprot:BCL2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:BCL2_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	106999	37
# CDD	cd12153	F1-ATPase_epsilon
# ChiTaRS	ATP5E	human
# DISEASE	ATP5E_HUMAN	Mitochondrial complex V deficiency, nuclear 3 (MC5DN3) [MIM 614053]  A mitochondrial disorder with heterogeneous clinical manifestations including dysmorphic features, psychomotor retardation, hypotonia, growth retardation, cardiomyopathy, enlarged liver, hypoplastic kidneys and elevated lactate levels in urine, plasma and cerebrospinal fluid. {ECO 0000269|PubMed 20566710}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000243997	ENSP00000243997; ENSG00000124172
# Ensembl	ENST00000395659	ENSP00000379019; ENSG00000124172
# Ensembl	ENST00000395663	ENSP00000379023; ENSG00000124172
# FUNCTION	ATP5E_HUMAN	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (By similarity). {ECO 0000250}. 
# GO_component	GO:0000275	mitochondrial proton-transporting ATP synthase complex, catalytic core F(1); IMP:CACAO.
# GO_component	GO:0005753	mitochondrial proton-transporting ATP synthase complex; IDA:UniProtKB.
# GO_component	GO:0005759	mitochondrial matrix; TAS:Reactome.
# GO_function	GO:0022857	transmembrane transporter activity; IC:UniProtKB.
# GO_function	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism; IEA:InterPro.
# GO_process	GO:0006754	ATP biosynthetic process; TAS:Reactome.
# GO_process	GO:0042776	mitochondrial ATP synthesis coupled proton transport; IC:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.10.1620.20	-; 1.
# Genevisible	P56381	HS
# HGNC	HGNC:838	ATP5E
# IntAct	P56381	7
# InterPro	IPR006721	ATP_synth_F1_esu_mt
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Disease	H01369	[Inherited metabolic disease; Mitochondrial disease] Mitochondrial infantile bilateral striatal necrosis (MIBSN)
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	606153	gene
# MIM	614053	phenotype
# Organism	ATP5E_HUMAN	Homo sapiens (Human)
# Orphanet	254913	Isolated ATP synthase deficiency
# PANTHER	PTHR12448	PTHR12448
# Pfam	PF04627	ATP-synt_Eps
# Proteomes	UP000005640	Chromosome 20
# Reactome	R-HSA-163210	Formation of ATP by chemiosmotic coupling
# RecName	ATP5E_HUMAN	ATP synthase subunit epsilon, mitochondrial
# RefSeq	NP_008817	NM_006886.3
# SIMILARITY	Belongs to the eukaryotic ATPase epsilon family. {ECO	0000305}.
# SUBCELLULAR LOCATION	ATP5E_HUMAN	Mitochondrion. Mitochondrion inner membrane. 
# SUBUNIT	F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) seems to have nine subunits	 a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity). {ECO:0000250}. 
# SUPFAM	SSF48690	SSF48690
# TISSUE SPECIFICITY	ATP5E_HUMAN	Ubiquitous. 
# UCSC	uc002yal	human
# eggNOG	ENOG410Y5P5	LUCA
# eggNOG	KOG3495	Eukaryota
BLAST	swissprot:ATP5E_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ATP5E_HUMAN
BioCyc	ZFISH:HS04727-MONOMER	http://biocyc.org/getid?id=ZFISH:HS04727-MONOMER
COXPRESdb	514	http://coxpresdb.jp/data/gene/514.shtml
CleanEx	HS_ATP5E	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP5E
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1038/414865a	http://dx.doi.org/10.1038/414865a
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/bj3470017	http://dx.doi.org/10.1042/bj3470017
DOI	10.1073/pnas.160270997	http://dx.doi.org/10.1073/pnas.160270997
DOI	10.1093/hmg/ddq254	http://dx.doi.org/10.1093/hmg/ddq254
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
EMBL	AF052955	http://www.ebi.ac.uk/ena/data/view/AF052955
EMBL	AF077045	http://www.ebi.ac.uk/ena/data/view/AF077045
EMBL	AK315493	http://www.ebi.ac.uk/ena/data/view/AK315493
EMBL	AL109840	http://www.ebi.ac.uk/ena/data/view/AL109840
EMBL	BC001690	http://www.ebi.ac.uk/ena/data/view/BC001690
EMBL	BC003671	http://www.ebi.ac.uk/ena/data/view/BC003671
EMBL	BC105811	http://www.ebi.ac.uk/ena/data/view/BC105811
EMBL	BT007293	http://www.ebi.ac.uk/ena/data/view/BT007293
EMBL	CH471077	http://www.ebi.ac.uk/ena/data/view/CH471077
EMBL	CH471077	http://www.ebi.ac.uk/ena/data/view/CH471077
Ensembl	ENST00000243997	http://www.ensembl.org/id/ENST00000243997
Ensembl	ENST00000395659	http://www.ensembl.org/id/ENST00000395659
Ensembl	ENST00000395663	http://www.ensembl.org/id/ENST00000395663
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000275	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000275
GO_component	GO:0005753	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005753
GO_component	GO:0005759	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005759
GO_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GO_function	GO:0046933	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046933
GO_process	GO:0006754	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006754
GO_process	GO:0042776	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042776
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.10.1620.20	http://www.cathdb.info/version/latest/superfamily/1.10.1620.20
GeneCards	ATP5E	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP5E
GeneID	514	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=514
GeneTree	ENSGT00390000015470	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000015470
HGNC	HGNC:838	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:838
HOGENOM	HOG000214506	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000214506&db=HOGENOM6
HOVERGEN	HBG050611	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050611&db=HOVERGEN
HPA	HPA042142	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042142
InParanoid	P56381	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P56381
IntAct	P56381	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P56381*
InterPro	IPR006721	http://www.ebi.ac.uk/interpro/entry/IPR006721
Jabion	514	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=514
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Disease	H01369	http://www.genome.jp/dbget-bin/www_bget?H01369
KEGG_Gene	hsa:514	http://www.genome.jp/dbget-bin/www_bget?hsa:514
KEGG_Orthology	KO:K02135	http://www.genome.jp/dbget-bin/www_bget?KO:K02135
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	606153	http://www.ncbi.nlm.nih.gov/omim/606153
MIM	614053	http://www.ncbi.nlm.nih.gov/omim/614053
MINT	MINT-3021407	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3021407
OMA	SATRKCL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SATRKCL
Orphanet	254913	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=254913
OrthoDB	EOG091G16RI	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G16RI
PANTHER	PTHR12448	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12448
PSORT	swissprot:ATP5E_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ATP5E_HUMAN
PSORT-B	swissprot:ATP5E_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ATP5E_HUMAN
PSORT2	swissprot:ATP5E_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ATP5E_HUMAN
Pfam	PF04627	http://pfam.xfam.org/family/PF04627
PharmGKB	PA25128	http://www.pharmgkb.org/do/serve?objId=PA25128&objCls=Gene
Phobius	swissprot:ATP5E_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ATP5E_HUMAN
PhylomeDB	P56381	http://phylomedb.org/?seqid=P56381
ProteinModelPortal	P56381	http://www.proteinmodelportal.org/query/uniprot/P56381
PubMed	10727396	http://www.ncbi.nlm.nih.gov/pubmed/10727396
PubMed	10931946	http://www.ncbi.nlm.nih.gov/pubmed/10931946
PubMed	11780052	http://www.ncbi.nlm.nih.gov/pubmed/11780052
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	20566710	http://www.ncbi.nlm.nih.gov/pubmed/20566710
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-163210	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-163210
RefSeq	NP_008817	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_008817
SMR	P56381	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P56381
STRING	9606.ENSP00000243997	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000243997&targetmode=cogs
SUPFAM	SSF48690	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48690
UCSC	uc002yal	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002yal&org=rat
UniGene	Hs.177530	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.177530
UniProtKB	ATP5E_HUMAN	http://www.uniprot.org/uniprot/ATP5E_HUMAN
UniProtKB-AC	P56381	http://www.uniprot.org/uniprot/P56381
charge	swissprot:ATP5E_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ATP5E_HUMAN
eggNOG	ENOG410Y5P5	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y5P5
eggNOG	KOG3495	http://eggnogapi.embl.de/nog_data/html/tree/KOG3495
epestfind	swissprot:ATP5E_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ATP5E_HUMAN
garnier	swissprot:ATP5E_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ATP5E_HUMAN
helixturnhelix	swissprot:ATP5E_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATP5E_HUMAN
hmoment	swissprot:ATP5E_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ATP5E_HUMAN
iep	swissprot:ATP5E_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ATP5E_HUMAN
inforesidue	swissprot:ATP5E_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ATP5E_HUMAN
neXtProt	NX_P56381	http://www.nextprot.org/db/entry/NX_P56381
octanol	swissprot:ATP5E_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ATP5E_HUMAN
pepcoil	swissprot:ATP5E_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ATP5E_HUMAN
pepdigest	swissprot:ATP5E_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ATP5E_HUMAN
pepinfo	swissprot:ATP5E_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ATP5E_HUMAN
pepnet	swissprot:ATP5E_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ATP5E_HUMAN
pepstats	swissprot:ATP5E_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ATP5E_HUMAN
pepwheel	swissprot:ATP5E_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ATP5E_HUMAN
pepwindow	swissprot:ATP5E_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ATP5E_HUMAN
sigcleave	swissprot:ATP5E_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ATP5E_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	BEST1_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O76090-1; Sequence=Displayed; Name=3; IsoId=O76090-3; Sequence=VSP_008973, VSP_008974; Name=4; IsoId=O76090-4; Sequence=VSP_008973, VSP_008975; 
# AltName	BEST1_HUMAN	TU15B
# AltName	BEST1_HUMAN	Vitelliform macular dystrophy protein 2
# CCDS	CCDS31580	-. [O76090-1]
# CCDS	CCDS44623	-. [O76090-3]
# ChiTaRS	BEST1	human
# DISEASE	BEST1_HUMAN	Bestrophinopathy, autosomal recessive (ARB) [MIM 611809]  A retinopathy characterized by loss of central vision, an absent electro-oculogram light rise, and electroretinogram anomalies. {ECO 0000269|PubMed 18179881, ECO 0000269|PubMed 21330666, ECO 0000269|PubMed 26200502, ECO 0000269|PubMed 26720466}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	BEST1_HUMAN	Macular dystrophy, vitelliform, 2 (VMD2) [MIM 153700]  An autosomal dominant form of macular degeneration that usually begins in childhood or adolescence. VMD2 is characterized by typical 'egg-yolk' macular lesions due to abnormal accumulation of lipofuscin within and beneath the retinal pigment epithelium cells. Progression of the disease leads to destruction of the retinal pigment epithelium and vision loss. {ECO 0000269|PubMed 10331951, ECO 0000269|PubMed 10394929, ECO 0000269|PubMed 10453731, ECO 0000269|PubMed 10682987, ECO 0000269|PubMed 10798642, ECO 0000269|PubMed 11241846, ECO 0000269|PubMed 11449320, ECO 0000269|PubMed 12187431, ECO 0000269|PubMed 12324875, ECO 0000269|PubMed 13129869, ECO 0000269|PubMed 14517959, ECO 0000269|PubMed 15176385, ECO 0000269|PubMed 18766995, ECO 0000269|PubMed 19357557, ECO 0000269|PubMed 21330666, ECO 0000269|PubMed 9662395, ECO 0000269|PubMed 9700209}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	BEST1_HUMAN	Retinitis pigmentosa 50 (RP50) [MIM 613194]  A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. {ECO 0000269|PubMed 19853238}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	BEST1_HUMAN	Vitreoretinochoroidopathy, autosomal dominant (ADVIRC) [MIM 193220]  A disorder characterized by vitreoretinochoroidal dystrophy. The clinical presentation is variable. VRCP may be associated with cataract, nanophthalmos, microcornea, shallow anterior chamber, and glaucoma. {ECO 0000269|PubMed 15452077}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000378043	ENSP00000367282; ENSG00000167995. [O76090-1]
# Ensembl	ENST00000449131	ENSP00000399709; ENSG00000167995. [O76090-3]
# ExpressionAtlas	O76090	baseline and differential
# FUNCTION	BEST1_HUMAN	Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. {ECO 0000269|PubMed 11904445, ECO 0000269|PubMed 12907679, ECO 0000269|PubMed 18400985}. 
# GO_component	GO:0005829	cytosol; TAS:HGNC.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_component	GO:0016323	basolateral plasma membrane; IDA:UniProtKB.
# GO_component	GO:0034707	chloride channel complex; IDA:BHF-UCL.
# GO_function	GO:0005229	intracellular calcium activated chloride channel activity; TAS:Reactome.
# GO_function	GO:0005254	chloride channel activity; IDA:MGI.
# GO_function	GO:0015106	bicarbonate transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0006821	chloride transport; IDA:MGI.
# GO_process	GO:0007601	visual perception; TAS:ProtInc.
# GO_process	GO:0030321	transepithelial chloride transport; IDA:HGNC.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0050908	detection of light stimulus involved in visual perception; IEA:Ensembl.
# GO_process	GO:0051924	regulation of calcium ion transport; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	O76090	HS
# HGNC	HGNC:12703	BEST1
# INTERACTION	BEST1_HUMAN	Self; NbExp=2; IntAct=EBI-11693370, EBI-11693370; 
# InterPro	IPR000615	Bestrophin
# InterPro	IPR021134	Bestrophin/UPF0187
# InterPro	IPR033041	Best1
# KEGG_Brite	ko02000	Transporters
# KEGG_Disease	H00527	[Inherited metabolic disease; Nervous system disease; Eye disease] Retinitis pigmentosa (RP)
# KEGG_Disease	H00805	[Nervous system disease; Eye disease] Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
# KEGG_Disease	H00814	[Nervous system disease; Eye disease] Autosomal recessive bestrophinopathy (ARB)
# MIM	153700	phenotype
# MIM	193220	phenotype
# MIM	607854	gene
# MIM	611809	phenotype
# MIM	613194	phenotype
# Organism	BEST1_HUMAN	Homo sapiens (Human)
# Orphanet	1243	Best vitelliform macular dystrophy
# Orphanet	139455	Autosomal recessive bestrophinopathy
# Orphanet	263347	MRCS syndrome
# Orphanet	3086	Autosomal dominant vitreoretinochoroidopathy
# Orphanet	791	Retinitis pigmentosa
# Orphanet	99000	Adult-onset foveomacular vitelliform dystrophy
# PANTHER	PTHR10736	PTHR10736
# PANTHER	PTHR10736:SF4	PTHR10736:SF4
# PTM	BEST1_HUMAN	Phosphorylated by PP2A. {ECO 0000250}. 
# Pfam	PF01062	Bestrophin
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	BEST1_HUMAN	Bestrophin-1
# RefSeq	NP_001132915	NM_001139443.1. [O76090-3]
# RefSeq	NP_001287715	NM_001300786.1. [O76090-4]
# RefSeq	NP_001287716	NM_001300787.1
# RefSeq	NP_004174	NM_004183.3. [O76090-1]
# RefSeq	XP_005274272	XM_005274215.3
# RefSeq	XP_016873718	XM_017018229.1
# SEQUENCE CAUTION	Sequence=BAH12234.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAH13472.1; Type=Erroneous initiation; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the bestrophin family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	BEST1_HUMAN	Cell membrane {ECO 0000269|PubMed 19853238, ECO 0000269|PubMed 26200502}; Multi-pass membrane protein {ECO 0000269|PubMed 19853238}. Basolateral cell membrane {ECO 0000269|PubMed 19853238, ECO 0000269|PubMed 26200502}. 
# SUBUNIT	BEST1_HUMAN	Homooligomer (tetramer or pentamer) (PubMed 26200502). May interact with PPP2CB and PPP2R1B (By similarity). {ECO 0000250, ECO 0000269|PubMed 26200502}. 
# TCDB	1.A.46.1	the anion channel-forming bestrophin (bestrophin) family
# TISSUE SPECIFICITY	BEST1_HUMAN	Predominantly expressed in the basolateral membrane of the retinal pigment epithelium. 
# UCSC	uc001nsr	human. [O76090-1]
# WEB RESOURCE	BEST1_HUMAN	Name=Mutations of the BEST1 gene; Note=Retina International's Scientific Newsletter; URL="http //www.retina-international.org/mutations-best1-gene";
# WEB RESOURCE	BEST1_HUMAN	Name=VMD2 mutation database; URL="http //www-huge.uni-regensburg.de/VMD2_database/index.php?select_db=VMD2"; 
# eggNOG	ENOG410XS3J	LUCA
# eggNOG	KOG3547	Eukaryota
BLAST	swissprot:BEST1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:BEST1_HUMAN
BioCyc	ZFISH:ENSG00000167995-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000167995-MONOMER
COXPRESdb	7439	http://coxpresdb.jp/data/gene/7439.shtml
CleanEx	HS_BEST1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_BEST1
DOI	10.1001/archopht.118.4.538	http://dx.doi.org/10.1001/archopht.118.4.538
DOI	10.1002/humu.9	http://dx.doi.org/10.1002/humu.9
DOI	10.1002/humu.9189	http://dx.doi.org/10.1002/humu.9189
DOI	10.1006/geno.1999.5808	http://dx.doi.org/10.1006/geno.1999.5808
DOI	10.1007/s004390050972	http://dx.doi.org/10.1007/s004390050972
DOI	10.1007/s004390050986	http://dx.doi.org/10.1007/s004390050986
DOI	10.1016/S0002-9394(99)00327-X	http://dx.doi.org/10.1016/S0002-9394(99)00327-X
DOI	10.1016/S0161-6420(03)00575-X	http://dx.doi.org/10.1016/S0161-6420(03)00575-X
DOI	10.1016/j.ajhg.2007.08.004	http://dx.doi.org/10.1016/j.ajhg.2007.08.004
DOI	10.1016/j.ajhg.2009.09.015	http://dx.doi.org/10.1016/j.ajhg.2009.09.015
DOI	10.1038/915	http://dx.doi.org/10.1038/915
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.052692999	http://dx.doi.org/10.1073/pnas.052692999
DOI	10.1074/jbc.M306150200	http://dx.doi.org/10.1074/jbc.M306150200
DOI	10.1076/opge.22.2.107.2226	http://dx.doi.org/10.1076/opge.22.2.107.2226
DOI	10.1076/opge.23.2.129.2213	http://dx.doi.org/10.1076/opge.23.2.129.2213
DOI	10.1076/opge.23.3.167.7880	http://dx.doi.org/10.1076/opge.23.3.167.7880
DOI	10.1080/13816810802087394	http://dx.doi.org/10.1080/13816810802087394
DOI	10.1093/hmg/7.9.1517	http://dx.doi.org/10.1093/hmg/7.9.1517
DOI	10.1097/IAE.0b013e31819d4fda	http://dx.doi.org/10.1097/IAE.0b013e31819d4fda
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1152/ajpcell.00398.2007	http://dx.doi.org/10.1152/ajpcell.00398.2007
DOI	10.1167/iovs.04-0550	http://dx.doi.org/10.1167/iovs.04-0550
DOI	10.1167/iovs.10-6707	http://dx.doi.org/10.1167/iovs.10-6707
DOI	10.1167/iovs.15-16910	http://dx.doi.org/10.1167/iovs.15-16910
DOI	10.1167/iovs.15-18168	http://dx.doi.org/10.1167/iovs.15-18168
EMBL	AF057169	http://www.ebi.ac.uk/ena/data/view/AF057169
EMBL	AF057170	http://www.ebi.ac.uk/ena/data/view/AF057170
EMBL	AF073491	http://www.ebi.ac.uk/ena/data/view/AF073491
EMBL	AF073492	http://www.ebi.ac.uk/ena/data/view/AF073492
EMBL	AF073493	http://www.ebi.ac.uk/ena/data/view/AF073493
EMBL	AF073494	http://www.ebi.ac.uk/ena/data/view/AF073494
EMBL	AF073495	http://www.ebi.ac.uk/ena/data/view/AF073495
EMBL	AF073496	http://www.ebi.ac.uk/ena/data/view/AF073496
EMBL	AF073497	http://www.ebi.ac.uk/ena/data/view/AF073497
EMBL	AF073498	http://www.ebi.ac.uk/ena/data/view/AF073498
EMBL	AF073499	http://www.ebi.ac.uk/ena/data/view/AF073499
EMBL	AF073500	http://www.ebi.ac.uk/ena/data/view/AF073500
EMBL	AF073501	http://www.ebi.ac.uk/ena/data/view/AF073501
EMBL	AK289681	http://www.ebi.ac.uk/ena/data/view/AK289681
EMBL	AK295998	http://www.ebi.ac.uk/ena/data/view/AK295998
EMBL	AK301392	http://www.ebi.ac.uk/ena/data/view/AK301392
EMBL	AY515704	http://www.ebi.ac.uk/ena/data/view/AY515704
EMBL	BC015220	http://www.ebi.ac.uk/ena/data/view/BC015220
EMBL	BC041664	http://www.ebi.ac.uk/ena/data/view/BC041664
EMBL	CH471076	http://www.ebi.ac.uk/ena/data/view/CH471076
EMBL	CH471076	http://www.ebi.ac.uk/ena/data/view/CH471076
Ensembl	ENST00000378043	http://www.ensembl.org/id/ENST00000378043
Ensembl	ENST00000449131	http://www.ensembl.org/id/ENST00000449131
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_function	GO:0005229	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005229
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0015106	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015106
GO_process	GO:0006821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006821
GO_process	GO:0007601	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007601
GO_process	GO:0030321	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030321
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0050908	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050908
GO_process	GO:0051924	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051924
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	BEST1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=BEST1
GeneID	7439	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7439
GeneTree	ENSGT00390000002997	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002997
H-InvDB	HIX0036211	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0036211
HGNC	HGNC:12703	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:12703
HOVERGEN	HBG044928	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG044928&db=HOVERGEN
InParanoid	O76090	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O76090
InterPro	IPR000615	http://www.ebi.ac.uk/interpro/entry/IPR000615
InterPro	IPR021134	http://www.ebi.ac.uk/interpro/entry/IPR021134
InterPro	IPR033041	http://www.ebi.ac.uk/interpro/entry/IPR033041
Jabion	7439	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7439
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Disease	H00527	http://www.genome.jp/dbget-bin/www_bget?H00527
KEGG_Disease	H00805	http://www.genome.jp/dbget-bin/www_bget?H00805
KEGG_Disease	H00814	http://www.genome.jp/dbget-bin/www_bget?H00814
KEGG_Gene	hsa:7439	http://www.genome.jp/dbget-bin/www_bget?hsa:7439
KEGG_Orthology	KO:K13878	http://www.genome.jp/dbget-bin/www_bget?KO:K13878
MIM	153700	http://www.ncbi.nlm.nih.gov/omim/153700
MIM	193220	http://www.ncbi.nlm.nih.gov/omim/193220
MIM	607854	http://www.ncbi.nlm.nih.gov/omim/607854
MIM	611809	http://www.ncbi.nlm.nih.gov/omim/611809
MIM	613194	http://www.ncbi.nlm.nih.gov/omim/613194
MINT	MINT-239943	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-239943
OMA	FPSRRQG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FPSRRQG
Orphanet	1243	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1243
Orphanet	139455	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=139455
Orphanet	263347	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=263347
Orphanet	3086	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=3086
Orphanet	791	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=791
Orphanet	99000	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=99000
OrthoDB	EOG091G06XO	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G06XO
PANTHER	PTHR10736	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10736
PANTHER	PTHR10736:SF4	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10736:SF4
PSORT	swissprot:BEST1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:BEST1_HUMAN
PSORT-B	swissprot:BEST1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:BEST1_HUMAN
PSORT2	swissprot:BEST1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:BEST1_HUMAN
Pfam	PF01062	http://pfam.xfam.org/family/PF01062
PharmGKB	PA162377454	http://www.pharmgkb.org/do/serve?objId=PA162377454&objCls=Gene
Phobius	swissprot:BEST1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:BEST1_HUMAN
PhylomeDB	O76090	http://phylomedb.org/?seqid=O76090
ProteinModelPortal	O76090	http://www.proteinmodelportal.org/query/uniprot/O76090
PubMed	10331951	http://www.ncbi.nlm.nih.gov/pubmed/10331951
PubMed	10394929	http://www.ncbi.nlm.nih.gov/pubmed/10394929
PubMed	10453731	http://www.ncbi.nlm.nih.gov/pubmed/10453731
PubMed	10682987	http://www.ncbi.nlm.nih.gov/pubmed/10682987
PubMed	10766140	http://www.ncbi.nlm.nih.gov/pubmed/10766140
PubMed	10798642	http://www.ncbi.nlm.nih.gov/pubmed/10798642
PubMed	11241846	http://www.ncbi.nlm.nih.gov/pubmed/11241846
PubMed	11449320	http://www.ncbi.nlm.nih.gov/pubmed/11449320
PubMed	11904445	http://www.ncbi.nlm.nih.gov/pubmed/11904445
PubMed	12187431	http://www.ncbi.nlm.nih.gov/pubmed/12187431
PubMed	12324875	http://www.ncbi.nlm.nih.gov/pubmed/12324875
PubMed	12907679	http://www.ncbi.nlm.nih.gov/pubmed/12907679
PubMed	13129869	http://www.ncbi.nlm.nih.gov/pubmed/13129869
PubMed	14517959	http://www.ncbi.nlm.nih.gov/pubmed/14517959
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15176385	http://www.ncbi.nlm.nih.gov/pubmed/15176385
PubMed	15452077	http://www.ncbi.nlm.nih.gov/pubmed/15452077
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18179881	http://www.ncbi.nlm.nih.gov/pubmed/18179881
PubMed	18400985	http://www.ncbi.nlm.nih.gov/pubmed/18400985
PubMed	18766995	http://www.ncbi.nlm.nih.gov/pubmed/18766995
PubMed	19357557	http://www.ncbi.nlm.nih.gov/pubmed/19357557
PubMed	19853238	http://www.ncbi.nlm.nih.gov/pubmed/19853238
PubMed	21330666	http://www.ncbi.nlm.nih.gov/pubmed/21330666
PubMed	26200502	http://www.ncbi.nlm.nih.gov/pubmed/26200502
PubMed	26720466	http://www.ncbi.nlm.nih.gov/pubmed/26720466
PubMed	9662395	http://www.ncbi.nlm.nih.gov/pubmed/9662395
PubMed	9700209	http://www.ncbi.nlm.nih.gov/pubmed/9700209
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_001132915	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001132915
RefSeq	NP_001287715	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001287715
RefSeq	NP_001287716	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001287716
RefSeq	NP_004174	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004174
RefSeq	XP_005274272	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005274272
RefSeq	XP_016873718	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016873718
SMR	O76090	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O76090
STRING	9606.ENSP00000399709	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000399709&targetmode=cogs
TCDB	1.A.46.1	http://www.tcdb.org/search/result.php?tc=1.A.46.1
UCSC	uc001nsr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001nsr&org=rat
UniGene	Hs.524910	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.524910
UniGene	Hs.712676	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.712676
UniProtKB	BEST1_HUMAN	http://www.uniprot.org/uniprot/BEST1_HUMAN
UniProtKB-AC	O76090	http://www.uniprot.org/uniprot/O76090
charge	swissprot:BEST1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:BEST1_HUMAN
eggNOG	ENOG410XS3J	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS3J
eggNOG	KOG3547	http://eggnogapi.embl.de/nog_data/html/tree/KOG3547
epestfind	swissprot:BEST1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:BEST1_HUMAN
garnier	swissprot:BEST1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:BEST1_HUMAN
helixturnhelix	swissprot:BEST1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:BEST1_HUMAN
hmoment	swissprot:BEST1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:BEST1_HUMAN
iep	swissprot:BEST1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:BEST1_HUMAN
inforesidue	swissprot:BEST1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:BEST1_HUMAN
neXtProt	NX_O76090	http://www.nextprot.org/db/entry/NX_O76090
octanol	swissprot:BEST1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:BEST1_HUMAN
pepcoil	swissprot:BEST1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:BEST1_HUMAN
pepdigest	swissprot:BEST1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:BEST1_HUMAN
pepinfo	swissprot:BEST1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:BEST1_HUMAN
pepnet	swissprot:BEST1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:BEST1_HUMAN
pepstats	swissprot:BEST1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:BEST1_HUMAN
pepwheel	swissprot:BEST1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:BEST1_HUMAN
pepwindow	swissprot:BEST1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:BEST1_HUMAN
sigcleave	swissprot:BEST1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:BEST1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GBRA2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P47869-1; Sequence=Displayed; Name=2; IsoId=P47869-2; Sequence=VSP_054277, VSP_054278; Note=No experimental confirmation available.; 
# AltName	GBRA2_HUMAN	GABA(A) receptor subunit alpha-2
# CCDS	CCDS3471	-. [P47869-1]
# ChiTaRS	GABRA2	human
# DrugBank	DB00186	Lorazepam
# DrugBank	DB00189	Ethchlorvynol
# DrugBank	DB00228	Enflurane
# DrugBank	DB00231	Temazepam
# DrugBank	DB00237	Butabarbital
# DrugBank	DB00241	Butalbital
# DrugBank	DB00273	Topiramate
# DrugBank	DB00292	Etomidate
# DrugBank	DB00306	Talbutal
# DrugBank	DB00312	Pentobarbital
# DrugBank	DB00334	Olanzapine
# DrugBank	DB00349	Clobazam
# DrugBank	DB00371	Meprobamate
# DrugBank	DB00402	Eszopiclone
# DrugBank	DB00404	Alprazolam
# DrugBank	DB00418	Secobarbital
# DrugBank	DB00425	Zolpidem
# DrugBank	DB00475	Chlordiazepoxide
# DrugBank	DB00543	Amoxapine
# DrugBank	DB00546	Adinazolam
# DrugBank	DB00599	Thiopental
# DrugBank	DB00628	Clorazepate
# DrugBank	DB00659	Acamprosate
# DrugBank	DB00683	Midazolam
# DrugBank	DB00690	Flurazepam
# DrugBank	DB00753	Isoflurane
# DrugBank	DB00794	Primidone
# DrugBank	DB00801	Halazepam
# DrugBank	DB00818	Propofol
# DrugBank	DB00829	Diazepam
# DrugBank	DB00842	Oxazepam
# DrugBank	DB00849	Methylphenobarbital
# DrugBank	DB00897	Triazolam
# DrugBank	DB00898	Ethanol
# DrugBank	DB01028	Methoxyflurane
# DrugBank	DB01049	Ergoloid mesylate
# DrugBank	DB01068	Clonazepam
# DrugBank	DB01107	Methyprylon
# DrugBank	DB01159	Halothane
# DrugBank	DB01189	Desflurane
# DrugBank	DB01198	Zopiclone
# DrugBank	DB01205	Flumazenil
# DrugBank	DB01215	Estazolam
# DrugBank	DB01236	Sevoflurane
# DrugBank	DB01346	Quinidine barbiturate
# DrugBank	DB01351	Amobarbital
# DrugBank	DB01352	Aprobarbital
# DrugBank	DB01353	Butethal
# DrugBank	DB01354	Heptabarbital
# DrugBank	DB01355	Hexobarbital
# DrugBank	DB01437	Glutethimide
# DrugBank	DB01544	Flunitrazepam
# DrugBank	DB01558	Bromazepam
# DrugBank	DB01559	Clotiazepam
# DrugBank	DB01567	Fludiazepam
# DrugBank	DB01588	Prazepam
# DrugBank	DB01589	Quazepam
# DrugBank	DB01594	Cinolazepam
# DrugBank	DB01595	Nitrazepam
# Ensembl	ENST00000356504	ENSP00000348897; ENSG00000151834. [P47869-1]
# Ensembl	ENST00000381620	ENSP00000371033; ENSG00000151834. [P47869-1]
# Ensembl	ENST00000510861	ENSP00000421828; ENSG00000151834. [P47869-1]
# Ensembl	ENST00000514090	ENSP00000421300; ENSG00000151834. [P47869-1]
# ExpressionAtlas	P47869	baseline and differential
# FUNCTION	GBRA2_HUMAN	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030285	integral component of synaptic vesicle membrane; IDA:UniProtKB.
# GO_component	GO:0030424	axon; IEA:Ensembl.
# GO_component	GO:0030425	dendrite; IEA:Ensembl.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0043025	neuronal cell body; IEA:Ensembl.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0060077	inhibitory synapse; IEA:Ensembl.
# GO_component	GO:1902711	GABA-A receptor complex; IDA:GO_Central.
# GO_function	GO:0004890	GABA-A receptor activity; IEA:InterPro.
# GO_function	GO:0008503	benzodiazepine receptor activity; IMP:UniProtKB.
# GO_function	GO:0022851	GABA-gated chloride ion channel activity; IDA:GO_Central.
# GO_process	GO:0001505	regulation of neurotransmitter levels; IMP:UniProtKB.
# GO_process	GO:0006836	neurotransmitter transport; IMP:UniProtKB.
# GO_process	GO:0007214	gamma-aminobutyric acid signaling pathway; IMP:UniProtKB.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:1902476	chloride transmembrane transport; IDA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.70.170.10	-; 1.
# Genevisible	P47869	HS
# HGNC	HGNC:4076	GABRA2
# InterPro	IPR001390	GABAAa_rcpt
# InterPro	IPR005432	GABBAa2_rcpt
# InterPro	IPR006028	GABAA/Glycine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04727	GABAergic synapse
# KEGG_Pathway	ko05032	Morphine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# MIM	103780	phenotype
# MIM	137140	gene
# Organism	GBRA2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR18945	PTHR18945
# PIR	I57947	I57947
# POLYMORPHISM	Genetic variations in GABRA2 determine the genetic susceptibility to alcoholism [MIM	103780]. 
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00253	GABAARECEPTR
# PRINTS	PR01079	GABAARALPHA
# PRINTS	PR01615	GABAARALPHA2
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-112314	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
# Reactome	R-HSA-975298	Ligand-gated ion channel transport
# Reactome	R-HSA-977441	GABA A receptor activation
# RecName	GBRA2_HUMAN	Gamma-aminobutyric acid receptor subunit alpha-2
# RefSeq	NP_000798	NM_000807.3. [P47869-1]
# RefSeq	NP_001107647	NM_001114175.2. [P47869-1]
# RefSeq	NP_001273756	NM_001286827.2. [P47869-2]
# RefSeq	NP_001317619	NM_001330690.1
# RefSeq	XP_016863471	XM_017007982.1. [P47869-1]
# RefSeq	XP_016863472	XM_017007983.1. [P47869-1]
# SEQUENCE CAUTION	Sequence=BAD92532.1; Type=Erroneous initiation; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	GBRA2_HUMAN	Cell junction, synapse, postsynaptic cell membrane {ECO 0000250|UniProtKB P26048}; Multi-pass membrane protein {ECO 0000255}. Cell membrane {ECO 0000250|UniProtKB P26048}; Multi-pass membrane protein {ECO 0000255}. Cytoplasmic vesicle membrane {ECO 0000250|UniProtKB P23576}. 
# SUBUNIT	GBRA2_HUMAN	Generally pentameric. There are five types of GABA(A) receptor chains  alpha, beta, gamma, delta, and rho. Interacts with UBQLN1. Interacts with KIF21B. {ECO 0000250|UniProtKB P23576, ECO 0000250|UniProtKB P26048}. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TCDB	1.A.9.5	the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family
# TIGRFAMs	TIGR00860	LIC
# UCSC	uc003gxc	human. [P47869-1]
# WEB RESOURCE	GBRA2_HUMAN	Name=Protein Spotlight; Note=Forbidden fruit - Issue 56 of March 2005; URL="http //web.expasy.org/spotlight/back_issues/056";
# eggNOG	ENOG410XNQG	LUCA
# eggNOG	KOG3642	Eukaryota
BLAST	swissprot:GBRA2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GBRA2_HUMAN
BioCyc	ZFISH:ENSG00000151834-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000151834-MONOMER
COXPRESdb	2555	http://coxpresdb.jp/data/gene/2555.shtml
CleanEx	HS_GABRA2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GABRA2
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1086/383283	http://dx.doi.org/10.1086/383283
DrugBank	DB00186	http://www.drugbank.ca/drugs/DB00186
DrugBank	DB00189	http://www.drugbank.ca/drugs/DB00189
DrugBank	DB00228	http://www.drugbank.ca/drugs/DB00228
DrugBank	DB00231	http://www.drugbank.ca/drugs/DB00231
DrugBank	DB00237	http://www.drugbank.ca/drugs/DB00237
DrugBank	DB00241	http://www.drugbank.ca/drugs/DB00241
DrugBank	DB00273	http://www.drugbank.ca/drugs/DB00273
DrugBank	DB00292	http://www.drugbank.ca/drugs/DB00292
DrugBank	DB00306	http://www.drugbank.ca/drugs/DB00306
DrugBank	DB00312	http://www.drugbank.ca/drugs/DB00312
DrugBank	DB00334	http://www.drugbank.ca/drugs/DB00334
DrugBank	DB00349	http://www.drugbank.ca/drugs/DB00349
DrugBank	DB00371	http://www.drugbank.ca/drugs/DB00371
DrugBank	DB00402	http://www.drugbank.ca/drugs/DB00402
DrugBank	DB00404	http://www.drugbank.ca/drugs/DB00404
DrugBank	DB00418	http://www.drugbank.ca/drugs/DB00418
DrugBank	DB00425	http://www.drugbank.ca/drugs/DB00425
DrugBank	DB00475	http://www.drugbank.ca/drugs/DB00475
DrugBank	DB00543	http://www.drugbank.ca/drugs/DB00543
DrugBank	DB00546	http://www.drugbank.ca/drugs/DB00546
DrugBank	DB00599	http://www.drugbank.ca/drugs/DB00599
DrugBank	DB00628	http://www.drugbank.ca/drugs/DB00628
DrugBank	DB00659	http://www.drugbank.ca/drugs/DB00659
DrugBank	DB00683	http://www.drugbank.ca/drugs/DB00683
DrugBank	DB00690	http://www.drugbank.ca/drugs/DB00690
DrugBank	DB00753	http://www.drugbank.ca/drugs/DB00753
DrugBank	DB00794	http://www.drugbank.ca/drugs/DB00794
DrugBank	DB00801	http://www.drugbank.ca/drugs/DB00801
DrugBank	DB00818	http://www.drugbank.ca/drugs/DB00818
DrugBank	DB00829	http://www.drugbank.ca/drugs/DB00829
DrugBank	DB00842	http://www.drugbank.ca/drugs/DB00842
DrugBank	DB00849	http://www.drugbank.ca/drugs/DB00849
DrugBank	DB00897	http://www.drugbank.ca/drugs/DB00897
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01028	http://www.drugbank.ca/drugs/DB01028
DrugBank	DB01049	http://www.drugbank.ca/drugs/DB01049
DrugBank	DB01068	http://www.drugbank.ca/drugs/DB01068
DrugBank	DB01107	http://www.drugbank.ca/drugs/DB01107
DrugBank	DB01159	http://www.drugbank.ca/drugs/DB01159
DrugBank	DB01189	http://www.drugbank.ca/drugs/DB01189
DrugBank	DB01198	http://www.drugbank.ca/drugs/DB01198
DrugBank	DB01205	http://www.drugbank.ca/drugs/DB01205
DrugBank	DB01215	http://www.drugbank.ca/drugs/DB01215
DrugBank	DB01236	http://www.drugbank.ca/drugs/DB01236
DrugBank	DB01346	http://www.drugbank.ca/drugs/DB01346
DrugBank	DB01351	http://www.drugbank.ca/drugs/DB01351
DrugBank	DB01352	http://www.drugbank.ca/drugs/DB01352
DrugBank	DB01353	http://www.drugbank.ca/drugs/DB01353
DrugBank	DB01354	http://www.drugbank.ca/drugs/DB01354
DrugBank	DB01355	http://www.drugbank.ca/drugs/DB01355
DrugBank	DB01437	http://www.drugbank.ca/drugs/DB01437
DrugBank	DB01544	http://www.drugbank.ca/drugs/DB01544
DrugBank	DB01558	http://www.drugbank.ca/drugs/DB01558
DrugBank	DB01559	http://www.drugbank.ca/drugs/DB01559
DrugBank	DB01567	http://www.drugbank.ca/drugs/DB01567
DrugBank	DB01588	http://www.drugbank.ca/drugs/DB01588
DrugBank	DB01589	http://www.drugbank.ca/drugs/DB01589
DrugBank	DB01594	http://www.drugbank.ca/drugs/DB01594
DrugBank	DB01595	http://www.drugbank.ca/drugs/DB01595
EMBL	AB209295	http://www.ebi.ac.uk/ena/data/view/AB209295
EMBL	AC084352	http://www.ebi.ac.uk/ena/data/view/AC084352
EMBL	AC093745	http://www.ebi.ac.uk/ena/data/view/AC093745
EMBL	AC095060	http://www.ebi.ac.uk/ena/data/view/AC095060
EMBL	AC104072	http://www.ebi.ac.uk/ena/data/view/AC104072
EMBL	AK125179	http://www.ebi.ac.uk/ena/data/view/AK125179
EMBL	AK289662	http://www.ebi.ac.uk/ena/data/view/AK289662
EMBL	AK293466	http://www.ebi.ac.uk/ena/data/view/AK293466
EMBL	CH471069	http://www.ebi.ac.uk/ena/data/view/CH471069
EMBL	S62907	http://www.ebi.ac.uk/ena/data/view/S62907
Ensembl	ENST00000356504	http://www.ensembl.org/id/ENST00000356504
Ensembl	ENST00000381620	http://www.ensembl.org/id/ENST00000381620
Ensembl	ENST00000510861	http://www.ensembl.org/id/ENST00000510861
Ensembl	ENST00000514090	http://www.ensembl.org/id/ENST00000514090
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030285	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030285
GO_component	GO:0030424	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030424
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_component	GO:0060077	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060077
GO_component	GO:1902711	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902711
GO_function	GO:0004890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004890
GO_function	GO:0008503	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008503
GO_function	GO:0022851	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022851
GO_process	GO:0001505	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001505
GO_process	GO:0006836	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006836
GO_process	GO:0007214	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007214
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	GABRA2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GABRA2
GeneID	2555	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2555
GeneTree	ENSGT00760000119010	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119010
HGNC	HGNC:4076	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4076
HOGENOM	HOG000231337	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231337&db=HOGENOM6
HOVERGEN	HBG051707	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051707&db=HOVERGEN
InParanoid	P47869	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P47869
IntAct	P47869	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P47869*
InterPro	IPR001390	http://www.ebi.ac.uk/interpro/entry/IPR001390
InterPro	IPR005432	http://www.ebi.ac.uk/interpro/entry/IPR005432
InterPro	IPR006028	http://www.ebi.ac.uk/interpro/entry/IPR006028
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
Jabion	2555	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2555
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:2555	http://www.genome.jp/dbget-bin/www_bget?hsa:2555
KEGG_Orthology	KO:K05175	http://www.genome.jp/dbget-bin/www_bget?KO:K05175
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
KEGG_Pathway	ko05032	http://www.genome.jp/kegg-bin/show_pathway?ko05032
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
MIM	103780	http://www.ncbi.nlm.nih.gov/omim/103780
MIM	137140	http://www.ncbi.nlm.nih.gov/omim/137140
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00253	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00253
PRINTS	PR01079	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01079
PRINTS	PR01615	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01615
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:GBRA2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GBRA2_HUMAN
PSORT-B	swissprot:GBRA2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GBRA2_HUMAN
PSORT2	swissprot:GBRA2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GBRA2_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA28490	http://www.pharmgkb.org/do/serve?objId=PA28490&objCls=Gene
Phobius	swissprot:GBRA2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GBRA2_HUMAN
PhylomeDB	P47869	http://phylomedb.org/?seqid=P47869
ProteinModelPortal	P47869	http://www.proteinmodelportal.org/query/uniprot/P47869
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15024690	http://www.ncbi.nlm.nih.gov/pubmed/15024690
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	8391122	http://www.ncbi.nlm.nih.gov/pubmed/8391122
Reactome	R-HSA-112314	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112314
Reactome	R-HSA-975298	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-975298
Reactome	R-HSA-977441	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-977441
RefSeq	NP_000798	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000798
RefSeq	NP_001107647	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001107647
RefSeq	NP_001273756	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273756
RefSeq	NP_001317619	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001317619
RefSeq	XP_016863471	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016863471
RefSeq	XP_016863472	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016863472
STRING	9606.ENSP00000348897	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000348897&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TCDB	1.A.9.5	http://www.tcdb.org/search/result.php?tc=1.A.9.5
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc003gxc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003gxc&org=rat
UniGene	Hs.116250	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.116250
UniGene	Hs.48372	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.48372
UniProtKB	GBRA2_HUMAN	http://www.uniprot.org/uniprot/GBRA2_HUMAN
UniProtKB-AC	P47869	http://www.uniprot.org/uniprot/P47869
charge	swissprot:GBRA2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GBRA2_HUMAN
eggNOG	ENOG410XNQG	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNQG
eggNOG	KOG3642	http://eggnogapi.embl.de/nog_data/html/tree/KOG3642
epestfind	swissprot:GBRA2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GBRA2_HUMAN
garnier	swissprot:GBRA2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GBRA2_HUMAN
helixturnhelix	swissprot:GBRA2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GBRA2_HUMAN
hmoment	swissprot:GBRA2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GBRA2_HUMAN
iep	swissprot:GBRA2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GBRA2_HUMAN
inforesidue	swissprot:GBRA2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GBRA2_HUMAN
neXtProt	NX_P47869	http://www.nextprot.org/db/entry/NX_P47869
octanol	swissprot:GBRA2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GBRA2_HUMAN
pepcoil	swissprot:GBRA2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GBRA2_HUMAN
pepdigest	swissprot:GBRA2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GBRA2_HUMAN
pepinfo	swissprot:GBRA2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GBRA2_HUMAN
pepnet	swissprot:GBRA2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GBRA2_HUMAN
pepstats	swissprot:GBRA2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GBRA2_HUMAN
pepwheel	swissprot:GBRA2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GBRA2_HUMAN
pepwindow	swissprot:GBRA2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GBRA2_HUMAN
sigcleave	swissprot:GBRA2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GBRA2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TRPM5_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1 {ECO 0000269|PubMed 10607831, ECO 0000269|PubMed 15489334, ECO 0000269|PubMed 16554811}; IsoId=Q9NZQ8-1; Sequence=Displayed; Name=2 {ECO 0000269|Ref.4}; IsoId=Q9NZQ8-2; Sequence=VSP_052741; Name=3 {ECO 0000269|PubMed 10607831}; IsoId=Q9NZQ8-3; Sequence=VSP_052742, VSP_052743; Note=No experimental confirmation available. {ECO 0000305}; 
# AltName	TRPM5_HUMAN	Long transient receptor potential channel 5
# AltName	TRPM5_HUMAN	MLSN1- and TRP-related gene 1 protein
# CCDS	CCDS31340	-. [Q9NZQ8-1]
# Ensembl	ENST00000155858	ENSP00000155858; ENSG00000070985. [Q9NZQ8-1]
# ExpressionAtlas	Q9NZQ8	baseline and differential
# FUNCTION	TRPM5_HUMAN	Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent- specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5- triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage- dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals. {ECO 0000269|PubMed 14634208}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_component	GO:0030425	dendrite; IEA:Ensembl.
# GO_component	GO:0043025	neuronal cell body; IEA:Ensembl.
# GO_function	GO:0005216	ion channel activity; TAS:ProtInc.
# GO_function	GO:0005227	calcium activated cation channel activity; IEA:Ensembl.
# GO_function	GO:0005244	voltage-gated ion channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0005267	potassium channel activity; IEA:Ensembl.
# GO_function	GO:0005272	sodium channel activity; TAS:Reactome.
# GO_process	GO:0050909	sensory perception of taste; IEA:InterPro.
# GO_process	GO:0070588	calcium ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9NZQ8	HS
# HGNC	HGNC:14323	TRPM5
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR029577	TRPM5
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04742	Taste transduction
# MIM	604600	gene
# Organism	TRPM5_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR13800:SF5	PTHR13800:SF5
# Pfam	PF00520	Ion_trans
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-3295583	TRP channels
# RecName	TRPM5_HUMAN	Transient receptor potential cation channel subfamily M member 5
# RefSeq	NP_055370	NM_014555.3. [Q9NZQ8-1]
# SIMILARITY	Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM5 sub-subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	TRPM5_HUMAN	Cell membrane {ECO 0000255}; Multi-pass membrane protein {ECO 0000250|UniProtKB Q8TD43, ECO 0000255}. 
# TCDB	1.A.4.5	the transient receptor potential ca(2+) channel (trp-cc) family
# TISSUE SPECIFICITY	Strongly expressed in fetal brain, liver and kidney, and in adult prostate, testis, ovary, colon and peripheral blood leukocytes. Also expressed in a large proportion of Wilms' tumors and rhabdomyosarcomas. In monochromosomal cell lines shows exclusive paternal expression. {ECO:0000269|PubMed	10607831}. 
# TopDownProteomics	Q9NZQ8-3	-. [Q9NZQ8-3]
# UCSC	uc001lwm	human. [Q9NZQ8-1]
# eggNOG	ENOG410XR5B	LUCA
# eggNOG	KOG3614	Eukaryota
BLAST	swissprot:TRPM5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TRPM5_HUMAN
BioCyc	ZFISH:ENSG00000070985-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000070985-MONOMER
COXPRESdb	29850	http://coxpresdb.jp/data/gene/29850.shtml
CleanEx	HS_TRPM5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TRPM5
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1073/pnas.2334624100	http://dx.doi.org/10.1073/pnas.2334624100
DOI	10.1093/hmg/9.2.203	http://dx.doi.org/10.1093/hmg/9.2.203
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC124057	http://www.ebi.ac.uk/ena/data/view/AC124057
EMBL	AF177473	http://www.ebi.ac.uk/ena/data/view/AF177473
EMBL	AJ270996	http://www.ebi.ac.uk/ena/data/view/AJ270996
EMBL	BC093787	http://www.ebi.ac.uk/ena/data/view/BC093787
EMBL	BC093789	http://www.ebi.ac.uk/ena/data/view/BC093789
Ensembl	ENST00000155858	http://www.ensembl.org/id/ENST00000155858
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_function	GO:0005216	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005216
GO_function	GO:0005227	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005227
GO_function	GO:0005244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005244
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_function	GO:0005272	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005272
GO_process	GO:0050909	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050909
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	TRPM5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TRPM5
GeneID	29850	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29850
GeneTree	ENSGT00760000119127	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119127
HGNC	HGNC:14323	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14323
HOVERGEN	HBG108337	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108337&db=HOVERGEN
HPA	HPA042115	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042115
HPA	HPA043315	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA043315
InParanoid	Q9NZQ8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NZQ8
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR029577	http://www.ebi.ac.uk/interpro/entry/IPR029577
Jabion	29850	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=29850
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:29850	http://www.genome.jp/dbget-bin/www_bget?hsa:29850
KEGG_Orthology	KO:K04980	http://www.genome.jp/dbget-bin/www_bget?KO:K04980
KEGG_Pathway	ko04742	http://www.genome.jp/kegg-bin/show_pathway?ko04742
MIM	604600	http://www.ncbi.nlm.nih.gov/omim/604600
PANTHER	PTHR13800:SF5	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13800:SF5
PSORT	swissprot:TRPM5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TRPM5_HUMAN
PSORT-B	swissprot:TRPM5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TRPM5_HUMAN
PSORT2	swissprot:TRPM5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TRPM5_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
PharmGKB	PA37869	http://www.pharmgkb.org/do/serve?objId=PA37869&objCls=Gene
Phobius	swissprot:TRPM5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TRPM5_HUMAN
PhylomeDB	Q9NZQ8	http://phylomedb.org/?seqid=Q9NZQ8
ProteinModelPortal	Q9NZQ8	http://www.proteinmodelportal.org/query/uniprot/Q9NZQ8
PubMed	10607831	http://www.ncbi.nlm.nih.gov/pubmed/10607831
PubMed	14634208	http://www.ncbi.nlm.nih.gov/pubmed/14634208
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
Reactome	R-HSA-3295583	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3295583
RefSeq	NP_055370	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055370
STRING	9606.ENSP00000155858	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000155858&targetmode=cogs
TCDB	1.A.4.5	http://www.tcdb.org/search/result.php?tc=1.A.4.5
UCSC	uc001lwm	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001lwm&org=rat
UniGene	Hs.272287	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.272287
UniProtKB	TRPM5_HUMAN	http://www.uniprot.org/uniprot/TRPM5_HUMAN
UniProtKB-AC	Q9NZQ8	http://www.uniprot.org/uniprot/Q9NZQ8
charge	swissprot:TRPM5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TRPM5_HUMAN
eggNOG	ENOG410XR5B	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XR5B
eggNOG	KOG3614	http://eggnogapi.embl.de/nog_data/html/tree/KOG3614
epestfind	swissprot:TRPM5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TRPM5_HUMAN
garnier	swissprot:TRPM5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TRPM5_HUMAN
helixturnhelix	swissprot:TRPM5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRPM5_HUMAN
hmoment	swissprot:TRPM5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TRPM5_HUMAN
iep	swissprot:TRPM5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TRPM5_HUMAN
inforesidue	swissprot:TRPM5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TRPM5_HUMAN
neXtProt	NX_Q9NZQ8	http://www.nextprot.org/db/entry/NX_Q9NZQ8
octanol	swissprot:TRPM5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TRPM5_HUMAN
pepcoil	swissprot:TRPM5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TRPM5_HUMAN
pepdigest	swissprot:TRPM5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TRPM5_HUMAN
pepinfo	swissprot:TRPM5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TRPM5_HUMAN
pepnet	swissprot:TRPM5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TRPM5_HUMAN
pepstats	swissprot:TRPM5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TRPM5_HUMAN
pepwheel	swissprot:TRPM5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TRPM5_HUMAN
pepwindow	swissprot:TRPM5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TRPM5_HUMAN
sigcleave	swissprot:TRPM5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TRPM5_HUMAN
## Database	ID	URL or Descriptions
# AltName	MOT3_HUMAN	Solute carrier family 16 member 8
# BioGrid	117083	2
# CDD	cd06174	MFS
# DrugBank	DB00119	Pyruvic acid
# Ensembl	ENST00000320521	ENSP00000321735; ENSG00000100156
# ExpressionAtlas	O95907	baseline and differential
# FUNCTION	MOT3_HUMAN	Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_function	GO:0008028	monocarboxylic acid transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015129	lactate transmembrane transporter activity; EXP:Reactome.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_process	GO:0006090	pyruvate metabolic process; TAS:Reactome.
# GO_process	GO:0015727	lactate transport; TAS:ProtInc.
# GO_process	GO:0035879	plasma membrane lactate transport; IBA:GO_Central.
# GO_process	GO:0050900	leukocyte migration; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0048870	cell motility
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	O95907	HS
# HGNC	HGNC:16270	SLC16A8
# IntAct	O95907	2
# InterPro	IPR004743	MCT
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# InterPro	IPR030759	MCT3
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	610409	gene
# Organism	MOT3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11360:SF26	PTHR11360:SF26
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 22
# Reactome	R-HSA-210991	Basigin interactions
# Reactome	R-HSA-433692	Proton-coupled monocarboxylate transport
# Reactome	R-HSA-70268	Pyruvate metabolism
# RecName	MOT3_HUMAN	Monocarboxylate transporter 3
# RefSeq	NP_037488	NM_013356.2
# RefSeq	XP_016884174	XM_017028685.1
# SIMILARITY	Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	MOT3_HUMAN	Cell membrane; Multi-pass membrane protein. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.13	the major facilitator superfamily (mfs)
# TIGRFAMs	TIGR00892	2A0113
# TISSUE SPECIFICITY	MOT3_HUMAN	Retinal pigment epithelium. 
# UCSC	uc003auu	human
# eggNOG	COG0477	LUCA
# eggNOG	KOG2504	Eukaryota
BLAST	swissprot:MOT3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MOT3_HUMAN
BioCyc	ZFISH:ENSG00000100156-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000100156-MONOMER
COXPRESdb	23539	http://coxpresdb.jp/data/gene/23539.shtml
CleanEx	HS_SLC16A8	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC16A8
DOI	10.1006/geno.1999.5926	http://dx.doi.org/10.1006/geno.1999.5926
DOI	10.1038/990031	http://dx.doi.org/10.1038/990031
DrugBank	DB00119	http://www.drugbank.ca/drugs/DB00119
EMBL	AF132610	http://www.ebi.ac.uk/ena/data/view/AF132610
EMBL	AF132611	http://www.ebi.ac.uk/ena/data/view/AF132611
EMBL	AL031587	http://www.ebi.ac.uk/ena/data/view/AL031587
Ensembl	ENST00000320521	http://www.ensembl.org/id/ENST00000320521
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0008028	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008028
GO_function	GO:0015129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015129
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_process	GO:0006090	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006090
GO_process	GO:0015727	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015727
GO_process	GO:0035879	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035879
GO_process	GO:0050900	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050900
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC16A8	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC16A8
GeneID	23539	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23539
GeneTree	ENSGT00760000118926	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118926
H-InvDB	HIX0041123	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0041123
HGNC	HGNC:16270	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16270
HOGENOM	HOG000280688	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280688&db=HOGENOM6
HOVERGEN	HBG006384	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006384&db=HOVERGEN
HPA	CAB010251	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB010251
InParanoid	O95907	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O95907
IntAct	O95907	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O95907*
InterPro	IPR004743	http://www.ebi.ac.uk/interpro/entry/IPR004743
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
InterPro	IPR030759	http://www.ebi.ac.uk/interpro/entry/IPR030759
Jabion	23539	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=23539
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:23539	http://www.genome.jp/dbget-bin/www_bget?hsa:23539
KEGG_Orthology	KO:K08185	http://www.genome.jp/dbget-bin/www_bget?KO:K08185
MIM	610409	http://www.ncbi.nlm.nih.gov/omim/610409
MINT	MINT-1429542	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1429542
OMA	VCTDRAF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VCTDRAF
OrthoDB	EOG091G05SW	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05SW
PANTHER	PTHR11360:SF26	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11360:SF26
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:MOT3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MOT3_HUMAN
PSORT-B	swissprot:MOT3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MOT3_HUMAN
PSORT2	swissprot:MOT3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MOT3_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA38106	http://www.pharmgkb.org/do/serve?objId=PA38106&objCls=Gene
Phobius	swissprot:MOT3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MOT3_HUMAN
PhylomeDB	O95907	http://phylomedb.org/?seqid=O95907
ProteinModelPortal	O95907	http://www.proteinmodelportal.org/query/uniprot/O95907
PubMed	10493836	http://www.ncbi.nlm.nih.gov/pubmed/10493836
PubMed	10591208	http://www.ncbi.nlm.nih.gov/pubmed/10591208
Reactome	R-HSA-210991	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-210991
Reactome	R-HSA-433692	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-433692
Reactome	R-HSA-70268	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-70268
RefSeq	NP_037488	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_037488
RefSeq	XP_016884174	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016884174
STRING	9606.ENSP00000321735	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000321735&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.13	http://www.tcdb.org/search/result.php?tc=2.A.1.13
TIGRFAMs	TIGR00892	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00892
UCSC	uc003auu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003auu&org=rat
UniGene	Hs.745256	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.745256
UniProtKB	MOT3_HUMAN	http://www.uniprot.org/uniprot/MOT3_HUMAN
UniProtKB-AC	O95907	http://www.uniprot.org/uniprot/O95907
charge	swissprot:MOT3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MOT3_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG2504	http://eggnogapi.embl.de/nog_data/html/tree/KOG2504
epestfind	swissprot:MOT3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MOT3_HUMAN
garnier	swissprot:MOT3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MOT3_HUMAN
helixturnhelix	swissprot:MOT3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MOT3_HUMAN
hmoment	swissprot:MOT3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MOT3_HUMAN
iep	swissprot:MOT3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MOT3_HUMAN
inforesidue	swissprot:MOT3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MOT3_HUMAN
neXtProt	NX_O95907	http://www.nextprot.org/db/entry/NX_O95907
octanol	swissprot:MOT3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MOT3_HUMAN
pepcoil	swissprot:MOT3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MOT3_HUMAN
pepdigest	swissprot:MOT3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MOT3_HUMAN
pepinfo	swissprot:MOT3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MOT3_HUMAN
pepnet	swissprot:MOT3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MOT3_HUMAN
pepstats	swissprot:MOT3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MOT3_HUMAN
pepwheel	swissprot:MOT3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MOT3_HUMAN
pepwindow	swissprot:MOT3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MOT3_HUMAN
sigcleave	swissprot:MOT3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MOT3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S38AB_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q08AI6-1; Sequence=Displayed; Name=2; IsoId=Q08AI6-2; Sequence=VSP_032529; 
# AltName	S38AB_HUMAN	Solute carrier family 38 member 11
# CCDS	CCDS2224	-. [Q08AI6-2]
# CCDS	CCDS56142	-. [Q08AI6-1]
# ChiTaRS	SLC38A11	human
# Ensembl	ENST00000303735	ENSP00000306178; ENSG00000169507. [Q08AI6-2]
# Ensembl	ENST00000409149	ENSP00000386272; ENSG00000169507. [Q08AI6-1]
# Ensembl	ENST00000409662	ENSP00000386774; ENSG00000169507. [Q08AI6-1]
# ExpressionAtlas	Q08AI6	baseline and differential
# FUNCTION	S38AB_HUMAN	Putative sodium-dependent amino acid/proton antiporter. {ECO 0000305}. 
# GO_component	GO:0005783	endoplasmic reticulum; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0003333	amino acid transmembrane transport; IBA:GO_Central.
# GO_process	GO:0006814	sodium ion transport; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q08AI6	HS
# HGNC	HGNC:26836	SLC38A11
# InterPro	IPR013057	AA_transpt_TM
# KEGG_Brite	ko02001	Solute carrier family
# MIM	616526	gene
# Organism	S38AB_HUMAN	Homo sapiens (Human)
# Pfam	PF01490	Aa_trans
# Proteomes	UP000005640	Chromosome 2
# RecName	S38AB_HUMAN	Putative sodium-coupled neutral amino acid transporter 11
# RefSeq	NP_001186077	NM_001199148.1. [Q08AI6-1]
# RefSeq	NP_775783	NM_173512.2. [Q08AI6-2]
# SIMILARITY	Belongs to the amino acid/polyamine transporter 2 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S38AB_HUMAN	Membrane {ECO 0000255}; Multi-pass membrane protein {ECO 0000255}. 
# TCDB	2.A.18.6.18	the amino acid/auxin permease (aaap) family
# UCSC	uc002ucu	human. [Q08AI6-1]
# eggNOG	COG0814	LUCA
# eggNOG	KOG1305	Eukaryota
BLAST	swissprot:S38AB_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S38AB_HUMAN
COXPRESdb	151258	http://coxpresdb.jp/data/gene/151258.shtml
CleanEx	HS_SLC38A11	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC38A11
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC019197	http://www.ebi.ac.uk/ena/data/view/AC019197
EMBL	AK097141	http://www.ebi.ac.uk/ena/data/view/AK097141
EMBL	AK293998	http://www.ebi.ac.uk/ena/data/view/AK293998
EMBL	BC125157	http://www.ebi.ac.uk/ena/data/view/BC125157
EMBL	CH471058	http://www.ebi.ac.uk/ena/data/view/CH471058
Ensembl	ENST00000303735	http://www.ensembl.org/id/ENST00000303735
Ensembl	ENST00000409149	http://www.ensembl.org/id/ENST00000409149
Ensembl	ENST00000409662	http://www.ensembl.org/id/ENST00000409662
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_process	GO:0003333	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003333
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC38A11	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC38A11
GeneID	151258	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=151258
GeneTree	ENSGT00760000119147	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119147
HGNC	HGNC:26836	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:26836
HOGENOM	HOG000188354	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000188354&db=HOGENOM6
HOVERGEN	HBG106990	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG106990&db=HOVERGEN
HPA	HPA043432	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA043432
InParanoid	Q08AI6	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q08AI6
InterPro	IPR013057	http://www.ebi.ac.uk/interpro/entry/IPR013057
Jabion	151258	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=151258
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:151258	http://www.genome.jp/dbget-bin/www_bget?hsa:151258
KEGG_Orthology	KO:K14997	http://www.genome.jp/dbget-bin/www_bget?KO:K14997
MIM	616526	http://www.ncbi.nlm.nih.gov/omim/616526
PSORT	swissprot:S38AB_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S38AB_HUMAN
PSORT-B	swissprot:S38AB_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S38AB_HUMAN
PSORT2	swissprot:S38AB_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S38AB_HUMAN
Pfam	PF01490	http://pfam.xfam.org/family/PF01490
PharmGKB	PA162403771	http://www.pharmgkb.org/do/serve?objId=PA162403771&objCls=Gene
Phobius	swissprot:S38AB_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S38AB_HUMAN
PhylomeDB	Q08AI6	http://phylomedb.org/?seqid=Q08AI6
ProteinModelPortal	Q08AI6	http://www.proteinmodelportal.org/query/uniprot/Q08AI6
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
RefSeq	NP_001186077	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001186077
RefSeq	NP_775783	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_775783
STRING	9606.ENSP00000386272	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000386272&targetmode=cogs
TCDB	2.A.18.6.18	http://www.tcdb.org/search/result.php?tc=2.A.18.6.18
UCSC	uc002ucu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ucu&org=rat
UniGene	Hs.658702	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.658702
UniProtKB	S38AB_HUMAN	http://www.uniprot.org/uniprot/S38AB_HUMAN
UniProtKB-AC	Q08AI6	http://www.uniprot.org/uniprot/Q08AI6
charge	swissprot:S38AB_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S38AB_HUMAN
eggNOG	COG0814	http://eggnogapi.embl.de/nog_data/html/tree/COG0814
eggNOG	KOG1305	http://eggnogapi.embl.de/nog_data/html/tree/KOG1305
epestfind	swissprot:S38AB_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S38AB_HUMAN
garnier	swissprot:S38AB_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S38AB_HUMAN
helixturnhelix	swissprot:S38AB_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S38AB_HUMAN
hmoment	swissprot:S38AB_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S38AB_HUMAN
iep	swissprot:S38AB_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S38AB_HUMAN
inforesidue	swissprot:S38AB_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S38AB_HUMAN
neXtProt	NX_Q08AI6	http://www.nextprot.org/db/entry/NX_Q08AI6
octanol	swissprot:S38AB_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S38AB_HUMAN
pepcoil	swissprot:S38AB_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S38AB_HUMAN
pepdigest	swissprot:S38AB_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S38AB_HUMAN
pepinfo	swissprot:S38AB_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S38AB_HUMAN
pepnet	swissprot:S38AB_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S38AB_HUMAN
pepstats	swissprot:S38AB_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S38AB_HUMAN
pepwheel	swissprot:S38AB_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S38AB_HUMAN
pepwindow	swissprot:S38AB_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S38AB_HUMAN
sigcleave	swissprot:S38AB_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S38AB_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SV2B_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7L1I2-1; Sequence=Displayed; Name=2; IsoId=Q7L1I2-2; Sequence=VSP_045194; Note=No experimental confirmation available.; 
# BioGrid	115228	3
# CCDS	CCDS10370	-. [Q7L1I2-1]
# CCDS	CCDS53972	-. [Q7L1I2-2]
# CDD	cd06174	MFS; 2
# ChiTaRS	SV2B	human
# Ensembl	ENST00000330276	ENSP00000332818; ENSG00000185518. [Q7L1I2-1]
# Ensembl	ENST00000394232	ENSP00000377779; ENSG00000185518. [Q7L1I2-1]
# Ensembl	ENST00000545111	ENSP00000443243; ENSG00000185518. [Q7L1I2-2]
# Ensembl	ENST00000557410	ENSP00000450992; ENSG00000185518. [Q7L1I2-1]
# FUNCTION	SV2B_HUMAN	Probably plays a role in the control of regulated secretion in neural and endocrine cells. {ECO 0000250}. 
# GO_component	GO:0001669	acrosomal vesicle; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008021	synaptic vesicle; ISS:ParkinsonsUK-UCL.
# GO_component	GO:0016020	membrane; ISS:ParkinsonsUK-UCL.
# GO_component	GO:0016021	integral component of membrane; IBA:GO_Central.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030672	synaptic vesicle membrane; IBA:GO_Central.
# GO_component	GO:0043005	neuron projection; IBA:GO_Central.
# GO_function	GO:0022857	transmembrane transporter activity; IEA:InterPro.
# GO_process	GO:0001504	neurotransmitter uptake; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q7L1I2	HS
# HGNC	HGNC:16874	SV2B
# INTERACTION	SV2B_HUMAN	Q96LI6 HSFY2; NbExp=3; IntAct=EBI-10290607, EBI-3957665; 
# InterPro	IPR001646	5peptide_repeat
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR005829	Sugar_transporter_CS
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# InterPro	IPR022308	SV2
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko04512	ECM-receptor interaction
# MIM	185861	gene
# Organism	SV2B_HUMAN	Homo sapiens (Human)
# PROSITE	PS50850	MFS
# PTM	SV2B_HUMAN	N-glycosylated. {ECO 0000250}. 
# PTM	SV2B_HUMAN	The N-terminal cytoplasmic domain is phosphorylated by CK1. {ECO 0000250}. 
# Pfam	PF00083	Sugar_tr
# Pfam	PF07690	MFS_1
# Pfam	PF13599	Pentapeptide_4
# Proteomes	UP000005640	Chromosome 15
# Reactome	R-HSA-5250955	Toxicity of botulinum toxin type D (BoNT/D)
# Reactome	R-HSA-5250968	Toxicity of botulinum toxin type A (BoNT/A)
# Reactome	R-HSA-5250981	Toxicity of botulinum toxin type F (BoNT/F)
# Reactome	R-HSA-5250992	Toxicity of botulinum toxin type E (BoNT/E)
# RecName	SV2B_HUMAN	Synaptic vesicle glycoprotein 2B
# RefSeq	NP_001161052	NM_001167580.2. [Q7L1I2-2]
# RefSeq	NP_001309960	NM_001323031.2. [Q7L1I2-1]
# RefSeq	NP_001309961	NM_001323032.2. [Q7L1I2-1]
# RefSeq	NP_001309966	NM_001323037.2. [Q7L1I2-1]
# RefSeq	NP_001309967	NM_001323038.2. [Q7L1I2-1]
# RefSeq	NP_001309968	NM_001323039.2. [Q7L1I2-1]
# RefSeq	NP_001309969	NM_001323040.2. [Q7L1I2-2]
# RefSeq	NP_055663	NM_014848.6. [Q7L1I2-1]
# RefSeq	XP_005255055	XM_005254998.3. [Q7L1I2-1]
# RefSeq	XP_016878250	XM_017022761.1. [Q7L1I2-1]
# RefSeq	XP_016878251	XM_017022762.1. [Q7L1I2-1]
# SEQUENCE CAUTION	Sequence=BAA34455.2; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the major facilitator superfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	SV2B_HUMAN	Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO 0000250|UniProtKB Q63564}; Multi- pass membrane protein {ECO 0000255}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO 0000250|UniProtKB Q63564}. Note=Associated with synaptic-like microvesicles but not with insulin-containing vesicles in insulin-secreting cells of the pancreas (By similarity). Localizes to microvesicles in the pinealocytes. Localizes to the acrosome in spermatids (By similarity). {ECO 0000250|UniProtKB Q63564}. 
# SUBUNIT	Interacts with SYT1 in a calcium-independent manner. Forms a complex with SYT1, syntaxin-1 and SNAP25 (By similarity). {ECO	0000250}. 
# SUPFAM	SSF103473	SSF103473; 3
# TIGRFAMs	TIGR01299	synapt_SV2
# UCSC	uc010uqv	human. [Q7L1I2-1]
# eggNOG	COG0477	LUCA
# eggNOG	KOG0255	Eukaryota
BLAST	swissprot:SV2B_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SV2B_HUMAN
BioCyc	ZFISH:G66-33611-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33611-MONOMER
COXPRESdb	9899	http://coxpresdb.jp/data/gene/9899.shtml
CleanEx	HS_SV2B	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SV2B
DOI	10.1038/nature04601	http://dx.doi.org/10.1038/nature04601
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/dnares/5.5.277	http://dx.doi.org/10.1093/dnares/5.5.277
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB018278	http://www.ebi.ac.uk/ena/data/view/AB018278
EMBL	AC123784	http://www.ebi.ac.uk/ena/data/view/AC123784
EMBL	AC127520	http://www.ebi.ac.uk/ena/data/view/AC127520
EMBL	AK294902	http://www.ebi.ac.uk/ena/data/view/AK294902
EMBL	BC030011	http://www.ebi.ac.uk/ena/data/view/BC030011
EMBL	CH471101	http://www.ebi.ac.uk/ena/data/view/CH471101
EMBL	CR457086	http://www.ebi.ac.uk/ena/data/view/CR457086
EMBL	FJ515843	http://www.ebi.ac.uk/ena/data/view/FJ515843
Ensembl	ENST00000330276	http://www.ensembl.org/id/ENST00000330276
Ensembl	ENST00000394232	http://www.ensembl.org/id/ENST00000394232
Ensembl	ENST00000545111	http://www.ensembl.org/id/ENST00000545111
Ensembl	ENST00000557410	http://www.ensembl.org/id/ENST00000557410
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0001669	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001669
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008021
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030672	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030672
GO_component	GO:0043005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043005
GO_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GO_process	GO:0001504	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001504
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SV2B	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SV2B
GeneID	9899	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9899
GeneTree	ENSGT00550000074384	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074384
HGNC	HGNC:16874	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16874
HOGENOM	HOG000065727	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000065727&db=HOGENOM6
HOVERGEN	HBG053967	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053967&db=HOVERGEN
HPA	HPA046247	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA046247
InParanoid	Q7L1I2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q7L1I2
IntAct	Q7L1I2	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q7L1I2*
InterPro	IPR001646	http://www.ebi.ac.uk/interpro/entry/IPR001646
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR005829	http://www.ebi.ac.uk/interpro/entry/IPR005829
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
InterPro	IPR022308	http://www.ebi.ac.uk/interpro/entry/IPR022308
Jabion	9899	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9899
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:9899	http://www.genome.jp/dbget-bin/www_bget?hsa:9899
KEGG_Orthology	KO:K06258	http://www.genome.jp/dbget-bin/www_bget?KO:K06258
KEGG_Pathway	ko04512	http://www.genome.jp/kegg-bin/show_pathway?ko04512
MIM	185861	http://www.ncbi.nlm.nih.gov/omim/185861
OMA	KMYFKHV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KMYFKHV
OrthoDB	EOG091G02NC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02NC
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:SV2B_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SV2B_HUMAN
PSORT-B	swissprot:SV2B_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SV2B_HUMAN
PSORT2	swissprot:SV2B_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SV2B_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
Pfam	PF13599	http://pfam.xfam.org/family/PF13599
PharmGKB	PA134930999	http://www.pharmgkb.org/do/serve?objId=PA134930999&objCls=Gene
Phobius	swissprot:SV2B_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SV2B_HUMAN
PhylomeDB	Q7L1I2	http://phylomedb.org/?seqid=Q7L1I2
ProteinModelPortal	Q7L1I2	http://www.proteinmodelportal.org/query/uniprot/Q7L1I2
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16572171	http://www.ncbi.nlm.nih.gov/pubmed/16572171
PubMed	9872452	http://www.ncbi.nlm.nih.gov/pubmed/9872452
Reactome	R-HSA-5250955	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5250955
Reactome	R-HSA-5250968	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5250968
Reactome	R-HSA-5250981	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5250981
Reactome	R-HSA-5250992	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5250992
RefSeq	NP_001161052	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001161052
RefSeq	NP_001309960	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001309960
RefSeq	NP_001309961	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001309961
RefSeq	NP_001309966	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001309966
RefSeq	NP_001309967	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001309967
RefSeq	NP_001309968	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001309968
RefSeq	NP_001309969	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001309969
RefSeq	NP_055663	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055663
RefSeq	XP_005255055	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005255055
RefSeq	XP_016878250	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016878250
RefSeq	XP_016878251	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016878251
STRING	9606.ENSP00000332818	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000332818&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TIGRFAMs	TIGR01299	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01299
UCSC	uc010uqv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010uqv&org=rat
UniGene	Hs.21754	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.21754
UniProtKB	SV2B_HUMAN	http://www.uniprot.org/uniprot/SV2B_HUMAN
UniProtKB-AC	Q7L1I2	http://www.uniprot.org/uniprot/Q7L1I2
charge	swissprot:SV2B_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SV2B_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG0255	http://eggnogapi.embl.de/nog_data/html/tree/KOG0255
epestfind	swissprot:SV2B_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SV2B_HUMAN
garnier	swissprot:SV2B_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SV2B_HUMAN
helixturnhelix	swissprot:SV2B_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SV2B_HUMAN
hmoment	swissprot:SV2B_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SV2B_HUMAN
iep	swissprot:SV2B_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SV2B_HUMAN
inforesidue	swissprot:SV2B_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SV2B_HUMAN
neXtProt	NX_Q7L1I2	http://www.nextprot.org/db/entry/NX_Q7L1I2
octanol	swissprot:SV2B_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SV2B_HUMAN
pepcoil	swissprot:SV2B_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SV2B_HUMAN
pepdigest	swissprot:SV2B_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SV2B_HUMAN
pepinfo	swissprot:SV2B_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SV2B_HUMAN
pepnet	swissprot:SV2B_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SV2B_HUMAN
pepstats	swissprot:SV2B_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SV2B_HUMAN
pepwheel	swissprot:SV2B_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SV2B_HUMAN
pepwindow	swissprot:SV2B_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SV2B_HUMAN
sigcleave	swissprot:SV2B_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SV2B_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCMB4_HUMAN	BK channel subunit beta-4
# AltName	KCMB4_HUMAN	Calcium-activated potassium channel, subfamily M subunit beta-4
# AltName	KCMB4_HUMAN	Charybdotoxin receptor subunit beta-4
# AltName	KCMB4_HUMAN	K(VCA)beta-4
# AltName	KCMB4_HUMAN	Maxi K channel subunit beta-4
# AltName	KCMB4_HUMAN	Slo-beta-4
# ChiTaRS	KCNMB4	human
# DOMAIN	KCMB4_HUMAN	Resistance to charybdotoxin (CTX) toxin is mediated by the extracellular domain. 
# DrugBank	DB00721	Procaine
# DrugBank	DB01110	Miconazole
# Ensembl	ENST00000258111	ENSP00000258111; ENSG00000135643
# ExpressionAtlas	Q86W47	baseline and differential
# FUNCTION	KCMB4_HUMAN	Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations. {ECO 0000269|PubMed 10692449, ECO 0000269|PubMed 10792058, ECO 0000269|PubMed 10828459}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IDA:UniProtKB.
# GO_function	GO:0015269	calcium-activated potassium channel activity; IDA:UniProtKB.
# GO_function	GO:0015459	potassium channel regulator activity; IBA:GO_Central.
# GO_process	GO:0001508	action potential; IDA:UniProtKB.
# GO_process	GO:0005513	detection of calcium ion; IDA:UniProtKB.
# GO_process	GO:0006813	potassium ion transport; IDA:UniProtKB.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:ProtInc.
# GO_process	GO:0019228	neuronal action potential; IDA:UniProtKB.
# GO_process	GO:0019229	regulation of vasoconstriction; TAS:UniProtKB.
# GO_process	GO:0046928	regulation of neurotransmitter secretion; TAS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0003013	circulatory system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q86W47	HS
# HGNC	HGNC:6289	KCNMB4
# InterPro	IPR003930	K_chnl_Ca-activ_BK_bsu
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04270	Vascular smooth muscle contraction
# MIM	605223	gene
# MISCELLANEOUS	KCMB4_HUMAN	Treatment with okadaic acid reduces its effect on KCNMA1. 
# Organism	KCMB4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10258	PTHR10258
# PTM	KCMB4_HUMAN	N-glycosylated. A highly glycosylated form is promoted by KCNMA1. Glycosylation, which is not required for the interaction with KCNMA1 and subcellular location, increases protection against charybdotoxin. {ECO 0000269|PubMed 10792058, ECO 0000269|PubMed 12223479}. 
# PTM	KCMB4_HUMAN	Phosphorylated. Phosphorylation modulates its effect on KCNMA1 activation kinetics. {ECO 0000269|PubMed 11790768}. 
# Pfam	PF03185	CaKB
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-1296052	Ca2+ activated K+ channels
# Reactome	R-HSA-418457	cGMP effects
# RecName	KCMB4_HUMAN	Calcium-activated potassium channel subunit beta-4
# RefSeq	NP_055320	NM_014505.5
# SIMILARITY	Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB4 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCMB4_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	KCMB4_HUMAN	Interacts with KCNMA1 tetramer (PubMed 10692449, PubMed 10804197). There are probably 4 molecules of KCMNB4 per KCNMA1 tetramer (PubMed 10692449, PubMed 10804197). Interacts with FMR1 (via N-terminus) (PubMed 25561520). {ECO 0000269|PubMed 10692449, ECO 0000269|PubMed 10804197, ECO 0000269|PubMed 25561520}. 
# TISSUE SPECIFICITY	KCMB4_HUMAN	Predominantly expressed in brain. In brain, it is expressed in the cerebellum, cerebral cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe, putamen, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Weakly or not expressed in other tissues. {ECO 0000269|PubMed 10692449, ECO 0000269|PubMed 10828459}. 
# UCSC	uc001svx	human
# eggNOG	ENOG410IJVB	Eukaryota
# eggNOG	ENOG410XSTD	LUCA
BLAST	swissprot:KCMB4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCMB4_HUMAN
COXPRESdb	27345	http://coxpresdb.jp/data/gene/27345.shtml
CleanEx	HS_KCNMB4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNMB4
DOI	10.1016/S0014-5793(00)01584-2	http://dx.doi.org/10.1016/S0014-5793(00)01584-2
DOI	10.1073/pnas.100118597	http://dx.doi.org/10.1073/pnas.100118597
DOI	10.1073/pnas.1423094112	http://dx.doi.org/10.1073/pnas.1423094112
DOI	10.1074/jbc.275.9.6453	http://dx.doi.org/10.1074/jbc.275.9.6453
DOI	10.1074/jbc.M107682200	http://dx.doi.org/10.1074/jbc.M107682200
DOI	10.1074/jbc.M205795200	http://dx.doi.org/10.1074/jbc.M205795200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1152/nips.01387.2002	http://dx.doi.org/10.1152/nips.01387.2002
DrugBank	DB00721	http://www.drugbank.ca/drugs/DB00721
DrugBank	DB01110	http://www.drugbank.ca/drugs/DB01110
EMBL	AF160967	http://www.ebi.ac.uk/ena/data/view/AF160967
EMBL	AF170917	http://www.ebi.ac.uk/ena/data/view/AF170917
EMBL	AF207992	http://www.ebi.ac.uk/ena/data/view/AF207992
EMBL	AF215891	http://www.ebi.ac.uk/ena/data/view/AF215891
EMBL	BC042446	http://www.ebi.ac.uk/ena/data/view/BC042446
EMBL	BC050621	http://www.ebi.ac.uk/ena/data/view/BC050621
Ensembl	ENST00000258111	http://www.ensembl.org/id/ENST00000258111
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_function	GO:0015269	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015269
GO_function	GO:0015459	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015459
GO_process	GO:0001508	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001508
GO_process	GO:0005513	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005513
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0019228	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019228
GO_process	GO:0019229	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019229
GO_process	GO:0046928	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046928
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0003013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003013
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	KCNMB4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNMB4
GeneID	27345	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27345
GeneTree	ENSGT00390000015997	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000015997
HGNC	HGNC:6289	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6289
HOGENOM	HOG000113205	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000113205&db=HOGENOM6
HOVERGEN	HBG052224	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052224&db=HOVERGEN
HPA	HPA072287	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA072287
InParanoid	Q86W47	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q86W47
InterPro	IPR003930	http://www.ebi.ac.uk/interpro/entry/IPR003930
Jabion	27345	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=27345
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:27345	http://www.genome.jp/dbget-bin/www_bget?hsa:27345
KEGG_Orthology	KO:K04941	http://www.genome.jp/dbget-bin/www_bget?KO:K04941
KEGG_Pathway	ko04270	http://www.genome.jp/kegg-bin/show_pathway?ko04270
MIM	605223	http://www.ncbi.nlm.nih.gov/omim/605223
OMA	ISEVFEC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ISEVFEC
OrthoDB	EOG091G0MVO	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0MVO
PANTHER	PTHR10258	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10258
PSORT	swissprot:KCMB4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCMB4_HUMAN
PSORT-B	swissprot:KCMB4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCMB4_HUMAN
PSORT2	swissprot:KCMB4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCMB4_HUMAN
Pfam	PF03185	http://pfam.xfam.org/family/PF03185
PharmGKB	PA30069	http://www.pharmgkb.org/do/serve?objId=PA30069&objCls=Gene
Phobius	swissprot:KCMB4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCMB4_HUMAN
PhylomeDB	Q86W47	http://phylomedb.org/?seqid=Q86W47
ProteinModelPortal	Q86W47	http://www.proteinmodelportal.org/query/uniprot/Q86W47
PubMed	10692449	http://www.ncbi.nlm.nih.gov/pubmed/10692449
PubMed	10792058	http://www.ncbi.nlm.nih.gov/pubmed/10792058
PubMed	10804197	http://www.ncbi.nlm.nih.gov/pubmed/10804197
PubMed	10828459	http://www.ncbi.nlm.nih.gov/pubmed/10828459
PubMed	11790768	http://www.ncbi.nlm.nih.gov/pubmed/11790768
PubMed	12136044	http://www.ncbi.nlm.nih.gov/pubmed/12136044
PubMed	12223479	http://www.ncbi.nlm.nih.gov/pubmed/12223479
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	25561520	http://www.ncbi.nlm.nih.gov/pubmed/25561520
Reactome	R-HSA-1296052	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296052
Reactome	R-HSA-418457	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418457
RefSeq	NP_055320	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055320
STRING	9606.ENSP00000258111	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000258111&targetmode=cogs
UCSC	uc001svx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001svx&org=rat
UniGene	Hs.525529	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.525529
UniProtKB	KCMB4_HUMAN	http://www.uniprot.org/uniprot/KCMB4_HUMAN
UniProtKB-AC	Q86W47	http://www.uniprot.org/uniprot/Q86W47
charge	swissprot:KCMB4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCMB4_HUMAN
eggNOG	ENOG410IJVB	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IJVB
eggNOG	ENOG410XSTD	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSTD
epestfind	swissprot:KCMB4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCMB4_HUMAN
garnier	swissprot:KCMB4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCMB4_HUMAN
helixturnhelix	swissprot:KCMB4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCMB4_HUMAN
hmoment	swissprot:KCMB4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCMB4_HUMAN
iep	swissprot:KCMB4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCMB4_HUMAN
inforesidue	swissprot:KCMB4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCMB4_HUMAN
neXtProt	NX_Q86W47	http://www.nextprot.org/db/entry/NX_Q86W47
octanol	swissprot:KCMB4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCMB4_HUMAN
pepcoil	swissprot:KCMB4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCMB4_HUMAN
pepdigest	swissprot:KCMB4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCMB4_HUMAN
pepinfo	swissprot:KCMB4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCMB4_HUMAN
pepnet	swissprot:KCMB4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCMB4_HUMAN
pepstats	swissprot:KCMB4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCMB4_HUMAN
pepwheel	swissprot:KCMB4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCMB4_HUMAN
pepwindow	swissprot:KCMB4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCMB4_HUMAN
sigcleave	swissprot:KCMB4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCMB4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	VPP1_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=I; IsoId=Q93050-2; Sequence=Displayed; Name=2; Synonyms=II; IsoId=Q93050-1; Sequence=VSP_012814; Name=3; IsoId=Q93050-3; Sequence=VSP_043532, VSP_012814; Note=No experimental confirmation available.; 
# AltName	VPP1_HUMAN	Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit
# AltName	VPP1_HUMAN	Vacuolar adenosine triphosphatase subunit Ac116
# AltName	VPP1_HUMAN	Vacuolar proton pump subunit 1
# AltName	VPP1_HUMAN	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1
# BioGrid	107018	77
# CCDS	CCDS11426	-. [Q93050-1]
# CCDS	CCDS45683	-. [Q93050-3]
# CCDS	CCDS45684	-. [Q93050-2]
# ChiTaRS	ATP6V0A1	human
# Ensembl	ENST00000264649	ENSP00000264649; ENSG00000033627. [Q93050-3]
# Ensembl	ENST00000343619	ENSP00000342951; ENSG00000033627. [Q93050-2]
# Ensembl	ENST00000393829	ENSP00000377415; ENSG00000033627. [Q93050-1]
# ExpressionAtlas	Q93050	baseline and differential
# FUNCTION	VPP1_HUMAN	Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). {ECO 0000250}. 
# GO_component	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
# GO_component	GO:0005623	cell; TAS:ParkinsonsUK-UCL.
# GO_component	GO:0005654	nucleoplasm; IDA:HPA.
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0005794	Golgi apparatus; IDA:HPA.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0010008	endosome membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0016471	vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
# GO_component	GO:0030670	phagocytic vesicle membrane; TAS:Reactome.
# GO_component	GO:0042470	melanosome; IEA:UniProtKB-SubCell.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
# GO_function	GO:0051117	ATPase binding; IPI:UniProtKB.
# GO_process	GO:0007035	vacuolar acidification; TAS:ParkinsonsUK-UCL.
# GO_process	GO:0008286	insulin receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0015986	ATP synthesis coupled proton transport; IBA:GO_Central.
# GO_process	GO:0015991	ATP hydrolysis coupled proton transport; IEA:InterPro.
# GO_process	GO:0016241	regulation of macroautophagy; IMP:ParkinsonsUK-UCL.
# GO_process	GO:0033572	transferrin transport; TAS:Reactome.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
# GO_process	GO:0090383	phagosome acidification; TAS:Reactome.
# GO_process	GO:1901998	toxin transport; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005623	cell
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q93050	HS
# HGNC	HGNC:865	ATP6V0A1
# IntAct	Q93050	28
# InterPro	IPR002490	V-ATPase_116kDa_su
# InterPro	IPR026028	V-type_ATPase_116kDa_su_euka
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04142	Lysosome
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04966	Collecting duct acid secretion
# KEGG_Pathway	ko05110	Vibrio cholerae infection
# KEGG_Pathway	ko05120	Epithelial cell signaling in Helicobacter pylori infection
# KEGG_Pathway	ko05152	Tuberculosis
# KEGG_Pathway	ko05323	Rheumatoid arthritis
# MIM	192130	gene
# Organism	VPP1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11629	PTHR11629
# PIR	T46449	T46449
# PIRSF	PIRSF001293	ATP6V0A1
# Pfam	PF01496	V_ATPase_I
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-1222556	ROS, RNS production in response to bacteria
# Reactome	R-HSA-6798695	Neutrophil degranulation
# Reactome	R-HSA-77387	Insulin receptor recycling
# Reactome	R-HSA-917977	Transferrin endocytosis and recycling
# Reactome	R-HSA-983712	Ion channel transport
# RecName	VPP1_HUMAN	V-type proton ATPase 116 kDa subunit a isoform 1
# RefSeq	NP_001123492	NM_001130020.1. [Q93050-3]
# RefSeq	NP_001123493	NM_001130021.1. [Q93050-2]
# RefSeq	NP_005168	NM_005177.3. [Q93050-1]
# SIMILARITY	Belongs to the V-ATPase 116 kDa subunit family. {ECO	0000305}.
# SUBCELLULAR LOCATION	VPP1_HUMAN	Cytoplasmic vesicle membrane; Multi-pass membrane protein. Melanosome. Note=Coated vesicle. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. 
# SUBUNIT	VPP1_HUMAN	The V-ATPase is a heteromultimeric enzyme composed of at least thirteen different subunits. It has a membrane peripheral V1 sector for ATP hydrolysis and an integral V0 for proton translocation. The V1 sector comprises subunits A-H, whereas V0 includes subunits a, d, c, c', and c''. 
# TCDB	3.A.2.2	the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily
# UCSC	uc002hzq	human. [Q93050-2]
# eggNOG	COG1269	LUCA
# eggNOG	KOG2189	Eukaryota
BLAST	swissprot:VPP1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VPP1_HUMAN
BioCyc	MetaCyc:ENSG00000033627-MONOMER	http://biocyc.org/getid?id=MetaCyc:ENSG00000033627-MONOMER
BioCyc	ZFISH:ENSG00000033627-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000033627-MONOMER
COG	COG1269	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1269
COXPRESdb	535	http://coxpresdb.jp/data/gene/535.shtml
CleanEx	HS_ATP6V0A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP6V0A1
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr025562r	http://dx.doi.org/10.1021/pr025562r
DOI	10.1021/pr060363j	http://dx.doi.org/10.1021/pr060363j
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AC067852	http://www.ebi.ac.uk/ena/data/view/AC067852
EMBL	AC107993	http://www.ebi.ac.uk/ena/data/view/AC107993
EMBL	AK295682	http://www.ebi.ac.uk/ena/data/view/AK295682
EMBL	AK316305	http://www.ebi.ac.uk/ena/data/view/AK316305
EMBL	AL137683	http://www.ebi.ac.uk/ena/data/view/AL137683
EMBL	BC032398	http://www.ebi.ac.uk/ena/data/view/BC032398
EMBL	CH471152	http://www.ebi.ac.uk/ena/data/view/CH471152
EMBL	Z71460	http://www.ebi.ac.uk/ena/data/view/Z71460
Ensembl	ENST00000264649	http://www.ensembl.org/id/ENST00000264649
Ensembl	ENST00000343619	http://www.ensembl.org/id/ENST00000343619
Ensembl	ENST00000393829	http://www.ensembl.org/id/ENST00000393829
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000220
GO_component	GO:0005623	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005623
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0010008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010008
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016471
GO_component	GO:0030670	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030670
GO_component	GO:0042470	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042470
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0046961	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046961
GO_function	GO:0051117	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051117
GO_process	GO:0007035	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007035
GO_process	GO:0008286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008286
GO_process	GO:0015986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015986
GO_process	GO:0015991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015991
GO_process	GO:0016241	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016241
GO_process	GO:0033572	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033572
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0070072	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070072
GO_process	GO:0090383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090383
GO_process	GO:1901998	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901998
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005623	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005623
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ATP6V0A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP6V0A1
GeneID	535	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=535
GeneTree	ENSGT00390000004941	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000004941
H-InvDB	HIX0013842	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0013842
HGNC	HGNC:865	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:865
HOGENOM	HOG000037059	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000037059&db=HOGENOM6
HOVERGEN	HBG014606	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG014606&db=HOVERGEN
HPA	HPA022144	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA022144
InParanoid	Q93050	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q93050
IntAct	Q93050	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q93050*
InterPro	IPR002490	http://www.ebi.ac.uk/interpro/entry/IPR002490
InterPro	IPR026028	http://www.ebi.ac.uk/interpro/entry/IPR026028
Jabion	535	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=535
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:535	http://www.genome.jp/dbget-bin/www_bget?hsa:535
KEGG_Orthology	KO:K02154	http://www.genome.jp/dbget-bin/www_bget?KO:K02154
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04142	http://www.genome.jp/kegg-bin/show_pathway?ko04142
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04966	http://www.genome.jp/kegg-bin/show_pathway?ko04966
KEGG_Pathway	ko05110	http://www.genome.jp/kegg-bin/show_pathway?ko05110
KEGG_Pathway	ko05120	http://www.genome.jp/kegg-bin/show_pathway?ko05120
KEGG_Pathway	ko05152	http://www.genome.jp/kegg-bin/show_pathway?ko05152
KEGG_Pathway	ko05323	http://www.genome.jp/kegg-bin/show_pathway?ko05323
MIM	192130	http://www.ncbi.nlm.nih.gov/omim/192130
MINT	MINT-3049850	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3049850
OMA	FTLYNWT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FTLYNWT
OrthoDB	EOG091G01BI	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01BI
PANTHER	PTHR11629	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11629
PSORT	swissprot:VPP1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VPP1_HUMAN
PSORT-B	swissprot:VPP1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VPP1_HUMAN
PSORT2	swissprot:VPP1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VPP1_HUMAN
Pfam	PF01496	http://pfam.xfam.org/family/PF01496
PharmGKB	PA25146	http://www.pharmgkb.org/do/serve?objId=PA25146&objCls=Gene
Phobius	swissprot:VPP1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VPP1_HUMAN
PhylomeDB	Q93050	http://phylomedb.org/?seqid=Q93050
ProteinModelPortal	Q93050	http://www.proteinmodelportal.org/query/uniprot/Q93050
PubMed	12643545	http://www.ncbi.nlm.nih.gov/pubmed/12643545
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	17081065	http://www.ncbi.nlm.nih.gov/pubmed/17081065
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
Reactome	R-HSA-1222556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1222556
Reactome	R-HSA-6798695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6798695
Reactome	R-HSA-77387	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-77387
Reactome	R-HSA-917977	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917977
Reactome	R-HSA-983712	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983712
RefSeq	NP_001123492	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001123492
RefSeq	NP_001123493	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001123493
RefSeq	NP_005168	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005168
STRING	9606.ENSP00000264649	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000264649&targetmode=cogs
STRING	COG1269	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1269&targetmode=cogs
TCDB	3.A.2.2	http://www.tcdb.org/search/result.php?tc=3.A.2.2
UCSC	uc002hzq	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002hzq&org=rat
UniGene	Hs.463074	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.463074
UniProtKB	VPP1_HUMAN	http://www.uniprot.org/uniprot/VPP1_HUMAN
UniProtKB-AC	Q93050	http://www.uniprot.org/uniprot/Q93050
charge	swissprot:VPP1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VPP1_HUMAN
eggNOG	COG1269	http://eggnogapi.embl.de/nog_data/html/tree/COG1269
eggNOG	KOG2189	http://eggnogapi.embl.de/nog_data/html/tree/KOG2189
epestfind	swissprot:VPP1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VPP1_HUMAN
garnier	swissprot:VPP1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VPP1_HUMAN
helixturnhelix	swissprot:VPP1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VPP1_HUMAN
hmoment	swissprot:VPP1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VPP1_HUMAN
iep	swissprot:VPP1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VPP1_HUMAN
inforesidue	swissprot:VPP1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VPP1_HUMAN
neXtProt	NX_Q93050	http://www.nextprot.org/db/entry/NX_Q93050
octanol	swissprot:VPP1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VPP1_HUMAN
pepcoil	swissprot:VPP1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VPP1_HUMAN
pepdigest	swissprot:VPP1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VPP1_HUMAN
pepinfo	swissprot:VPP1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VPP1_HUMAN
pepnet	swissprot:VPP1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VPP1_HUMAN
pepstats	swissprot:VPP1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VPP1_HUMAN
pepwheel	swissprot:VPP1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VPP1_HUMAN
pepwindow	swissprot:VPP1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VPP1_HUMAN
sigcleave	swissprot:VPP1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VPP1_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	125630	16
# Ensembl	ENST00000369893	ENSP00000358909; ENSG00000156398
# ExpressionAtlas	Q96NB2	baseline and differential
# FUNCTION	SFXN2_HUMAN	Potential iron transporter. 
# GO_component	GO:0005743	mitochondrial inner membrane; IEA:Ensembl.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015075	ion transmembrane transporter activity; IEA:InterPro.
# GO_process	GO:0055072	iron ion homeostasis; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0042592	homeostatic process
# Genevisible	Q96NB2	HS
# HGNC	HGNC:16086	SFXN2
# IntAct	Q96NB2	2
# InterPro	IPR004686	Mtc
# MIM	615570	gene
# Organism	SFXN2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11153	PTHR11153
# Pfam	PF03820	Mtc
# Proteomes	UP000005640	Chromosome 10
# RecName	SFXN2_HUMAN	Sideroflexin-2
# RefSeq	NP_849189	NM_178858.4
# RefSeq	XP_011537564	XM_011539262.2
# RefSeq	XP_016871152	XM_017015663.1
# SEQUENCE CAUTION	Sequence=BAB70993.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the sideroflexin family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	SFXN2_HUMAN	Mitochondrion membrane {ECO 0000250}; Multi- pass membrane protein {ECO 0000250}. 
# TIGRFAMs	TIGR00798	mtc
# TISSUE SPECIFICITY	Widely expressed, highest levels in kidney, liver, and pancreas. {ECO:0000269|PubMed	12670026}. 
# UCSC	uc001kwb	human
# eggNOG	ENOG410YU8V	LUCA
# eggNOG	KOG3767	Eukaryota
BLAST	swissprot:SFXN2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SFXN2_HUMAN
BioCyc	ZFISH:ENSG00000156398-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000156398-MONOMER
COXPRESdb	118980	http://coxpresdb.jp/data/gene/118980.shtml
CleanEx	HS_SFXN2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SFXN2
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1023/A:1022026001114	http://dx.doi.org/10.1023/A:1022026001114
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF462052	http://www.ebi.ac.uk/ena/data/view/AF462052
EMBL	AK055711	http://www.ebi.ac.uk/ena/data/view/AK055711
EMBL	BC022091	http://www.ebi.ac.uk/ena/data/view/BC022091
EMBL	CH471066	http://www.ebi.ac.uk/ena/data/view/CH471066
EMBL	CH471066	http://www.ebi.ac.uk/ena/data/view/CH471066
Ensembl	ENST00000369893	http://www.ensembl.org/id/ENST00000369893
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015075	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015075
GO_process	GO:0055072	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GeneCards	SFXN2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SFXN2
GeneID	118980	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=118980
GeneTree	ENSGT00390000002026	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002026
HGNC	HGNC:16086	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16086
HOGENOM	HOG000203440	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000203440&db=HOGENOM6
HOVERGEN	HBG056083	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG056083&db=HOVERGEN
HPA	HPA018150	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA018150
HPA	HPA026834	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA026834
InParanoid	Q96NB2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96NB2
IntAct	Q96NB2	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96NB2*
InterPro	IPR004686	http://www.ebi.ac.uk/interpro/entry/IPR004686
Jabion	118980	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=118980
KEGG_Gene	hsa:118980	http://www.genome.jp/dbget-bin/www_bget?hsa:118980
MIM	615570	http://www.ncbi.nlm.nih.gov/omim/615570
OMA	EQLHYAK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EQLHYAK
OrthoDB	EOG091G0BOU	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0BOU
PANTHER	PTHR11153	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11153
PSORT	swissprot:SFXN2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SFXN2_HUMAN
PSORT-B	swissprot:SFXN2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SFXN2_HUMAN
PSORT2	swissprot:SFXN2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SFXN2_HUMAN
Pfam	PF03820	http://pfam.xfam.org/family/PF03820
PharmGKB	PA38091	http://www.pharmgkb.org/do/serve?objId=PA38091&objCls=Gene
Phobius	swissprot:SFXN2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SFXN2_HUMAN
PhylomeDB	Q96NB2	http://phylomedb.org/?seqid=Q96NB2
ProteinModelPortal	Q96NB2	http://www.proteinmodelportal.org/query/uniprot/Q96NB2
PubMed	12670026	http://www.ncbi.nlm.nih.gov/pubmed/12670026
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
RefSeq	NP_849189	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_849189
RefSeq	XP_011537564	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011537564
RefSeq	XP_016871152	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016871152
STRING	9606.ENSP00000358909	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000358909&targetmode=cogs
TIGRFAMs	TIGR00798	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00798
UCSC	uc001kwb	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001kwb&org=rat
UniGene	Hs.44070	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.44070
UniProtKB	SFXN2_HUMAN	http://www.uniprot.org/uniprot/SFXN2_HUMAN
UniProtKB-AC	Q96NB2	http://www.uniprot.org/uniprot/Q96NB2
charge	swissprot:SFXN2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SFXN2_HUMAN
eggNOG	ENOG410YU8V	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YU8V
eggNOG	KOG3767	http://eggnogapi.embl.de/nog_data/html/tree/KOG3767
epestfind	swissprot:SFXN2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SFXN2_HUMAN
garnier	swissprot:SFXN2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SFXN2_HUMAN
helixturnhelix	swissprot:SFXN2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SFXN2_HUMAN
hmoment	swissprot:SFXN2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SFXN2_HUMAN
iep	swissprot:SFXN2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SFXN2_HUMAN
inforesidue	swissprot:SFXN2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SFXN2_HUMAN
neXtProt	NX_Q96NB2	http://www.nextprot.org/db/entry/NX_Q96NB2
octanol	swissprot:SFXN2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SFXN2_HUMAN
pepcoil	swissprot:SFXN2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SFXN2_HUMAN
pepdigest	swissprot:SFXN2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SFXN2_HUMAN
pepinfo	swissprot:SFXN2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SFXN2_HUMAN
pepnet	swissprot:SFXN2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SFXN2_HUMAN
pepstats	swissprot:SFXN2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SFXN2_HUMAN
pepwheel	swissprot:SFXN2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SFXN2_HUMAN
pepwindow	swissprot:SFXN2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SFXN2_HUMAN
sigcleave	swissprot:SFXN2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SFXN2_HUMAN
## Database	ID	URL or Descriptions
# AltName	GTR10_HUMAN	Glucose transporter type 10
# BIOPHYSICOCHEMICAL PROPERTIES	Kinetic parameters	 KM=0.28 mM for 2-deoxy-D-glucose; 
# CDD	cd06174	MFS
# ChiTaRS	SLC2A10	human
# DISEASE	GTR10_HUMAN	Arterial tortuosity syndrome (ATS) [MIM 208050]  An autosomal recessive disorder characterized by tortuosity and elongation of major arteries, often resulting in death at young age. Other typical features include aneurysms of large arteries and stenosis of the pulmonary artery, in association with facial features and several connective tissue manifestations such as soft skin and joint laxity. Histopathological findings include fragmentation of elastic fibers in the tunica media of large arteries. {ECO 0000269|PubMed 16550171, ECO 0000269|PubMed 17935213}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000359271	ENSP00000352216; ENSG00000197496
# ExpressionAtlas	O95528	baseline and differential
# FUNCTION	GTR10_HUMAN	Facilitative glucose transporter. 
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0012505	endomembrane system; IEA:UniProtKB-SubCell.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
# GO_function	GO:0005355	glucose transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0055056	D-glucose transmembrane transporter activity; TAS:Reactome.
# GO_function	GTR10_HUMAN	GO 0005351 sugar proton symporter activity; NAS UniProtKB.
# GO_process	GO:0015758	glucose transport; NAS:UniProtKB.
# GO_process	GO:0046323	glucose import; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	O95528	HS
# HGNC	HGNC:13444	SLC2A10
# InterPro	IPR003663	Sugar/inositol_transpt
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR005829	Sugar_transporter_CS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H00919	[Vascular disease] Arterial tortuosity syndrome
# MIM	208050	phenotype
# MIM	606145	gene
# Organism	GTR10_HUMAN	Homo sapiens (Human)
# Orphanet	3342	Arterial tortuosity syndrome
# PRINTS	PR00171	SUGRTRNSPORT
# PROSITE	PS00216	SUGAR_TRANSPORT_1; 2
# PROSITE	PS50850	MFS
# Pfam	PF00083	Sugar_tr; 2
# Proteomes	UP000005640	Chromosome 20
# Reactome	R-HSA-428790	Facilitative Na+-independent glucose transporters
# RecName	GTR10_HUMAN	Solute carrier family 2, facilitated glucose transporter member 10
# RefSeq	NP_110404	NM_030777.3
# SIMILARITY	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	GTR10_HUMAN	Endomembrane system {ECO 0000269|PubMed 16550171}; Multi-pass membrane protein {ECO 0000269|PubMed 16550171}. Cytoplasm, perinuclear region {ECO 0000269|PubMed 16550171}. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.1.1.59	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	Widely expressed; highest levels in liver and pancreas. {ECO:0000269|PubMed	11592815}. 
# UCSC	uc002xsl	human
# eggNOG	ENOG410XNQK	LUCA
# eggNOG	KOG0254	Eukaryota
BLAST	swissprot:GTR10_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GTR10_HUMAN
COXPRESdb	81031	http://coxpresdb.jp/data/gene/81031.shtml
CleanEx	HS_SLC2A10	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC2A10
DOI	10.1002/humu.20623	http://dx.doi.org/10.1002/humu.20623
DOI	10.1006/geno.2000.6457	http://dx.doi.org/10.1006/geno.2000.6457
DOI	10.1006/mgme.2001.3212	http://dx.doi.org/10.1006/mgme.2001.3212
DOI	10.1038/414865a	http://dx.doi.org/10.1038/414865a
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/ng1764	http://dx.doi.org/10.1038/ng1764
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.2337/diabetes.52.9.2445	http://dx.doi.org/10.2337/diabetes.52.9.2445
EMBL	AF248053	http://www.ebi.ac.uk/ena/data/view/AF248053
EMBL	AF321240	http://www.ebi.ac.uk/ena/data/view/AF321240
EMBL	AK290961	http://www.ebi.ac.uk/ena/data/view/AK290961
EMBL	AL031055	http://www.ebi.ac.uk/ena/data/view/AL031055
EMBL	AL137188	http://www.ebi.ac.uk/ena/data/view/AL137188
EMBL	BC101657	http://www.ebi.ac.uk/ena/data/view/BC101657
EMBL	BC113423	http://www.ebi.ac.uk/ena/data/view/BC113423
EMBL	CH471077	http://www.ebi.ac.uk/ena/data/view/CH471077
Ensembl	ENST00000359271	http://www.ensembl.org/id/ENST00000359271
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0012505	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0012505
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_function	GO:0005351	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005351
GO_function	GO:0005355	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005355
GO_function	GO:0055056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055056
GO_process	GO:0015758	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015758
GO_process	GO:0046323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046323
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC2A10	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC2A10
GeneID	81031	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81031
GeneTree	ENSGT00850000132274	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00850000132274
HGNC	HGNC:13444	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13444
HOGENOM	HOG000202868	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202868&db=HOGENOM6
HOVERGEN	HBG051858	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051858&db=HOVERGEN
HPA	HPA041015	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA041015
HPA	HPA055673	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA055673
InParanoid	O95528	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O95528
InterPro	IPR003663	http://www.ebi.ac.uk/interpro/entry/IPR003663
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR005829	http://www.ebi.ac.uk/interpro/entry/IPR005829
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	81031	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=81031
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00919	http://www.genome.jp/dbget-bin/www_bget?H00919
KEGG_Gene	hsa:81031	http://www.genome.jp/dbget-bin/www_bget?hsa:81031
KEGG_Orthology	KO:K08147	http://www.genome.jp/dbget-bin/www_bget?KO:K08147
MIM	208050	http://www.ncbi.nlm.nih.gov/omim/208050
MIM	606145	http://www.ncbi.nlm.nih.gov/omim/606145
OMA	PIPRTNE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PIPRTNE
Orphanet	3342	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=3342
OrthoDB	EOG091G085H	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G085H
PRINTS	PR00171	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00171
PROSITE	PS00216	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00216
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:GTR10_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GTR10_HUMAN
PSORT-B	swissprot:GTR10_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GTR10_HUMAN
PSORT2	swissprot:GTR10_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GTR10_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
PharmGKB	PA37769	http://www.pharmgkb.org/do/serve?objId=PA37769&objCls=Gene
Phobius	swissprot:GTR10_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GTR10_HUMAN
PhylomeDB	O95528	http://phylomedb.org/?seqid=O95528
ProteinModelPortal	O95528	http://www.proteinmodelportal.org/query/uniprot/O95528
PubMed	11247674	http://www.ncbi.nlm.nih.gov/pubmed/11247674
PubMed	11592815	http://www.ncbi.nlm.nih.gov/pubmed/11592815
PubMed	11780052	http://www.ncbi.nlm.nih.gov/pubmed/11780052
PubMed	12941788	http://www.ncbi.nlm.nih.gov/pubmed/12941788
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16550171	http://www.ncbi.nlm.nih.gov/pubmed/16550171
PubMed	17935213	http://www.ncbi.nlm.nih.gov/pubmed/17935213
Reactome	R-HSA-428790	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428790
RefSeq	NP_110404	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_110404
STRING	9606.ENSP00000352216	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000352216&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.1.59	http://www.tcdb.org/search/result.php?tc=2.A.1.1.59
UCSC	uc002xsl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002xsl&org=rat
UniGene	Hs.305971	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.305971
UniProtKB	GTR10_HUMAN	http://www.uniprot.org/uniprot/GTR10_HUMAN
UniProtKB-AC	O95528	http://www.uniprot.org/uniprot/O95528
charge	swissprot:GTR10_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GTR10_HUMAN
eggNOG	ENOG410XNQK	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNQK
eggNOG	KOG0254	http://eggnogapi.embl.de/nog_data/html/tree/KOG0254
epestfind	swissprot:GTR10_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GTR10_HUMAN
garnier	swissprot:GTR10_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GTR10_HUMAN
helixturnhelix	swissprot:GTR10_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GTR10_HUMAN
hmoment	swissprot:GTR10_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GTR10_HUMAN
iep	swissprot:GTR10_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GTR10_HUMAN
inforesidue	swissprot:GTR10_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GTR10_HUMAN
neXtProt	NX_O95528	http://www.nextprot.org/db/entry/NX_O95528
octanol	swissprot:GTR10_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GTR10_HUMAN
pepcoil	swissprot:GTR10_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GTR10_HUMAN
pepdigest	swissprot:GTR10_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GTR10_HUMAN
pepinfo	swissprot:GTR10_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GTR10_HUMAN
pepnet	swissprot:GTR10_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GTR10_HUMAN
pepstats	swissprot:GTR10_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GTR10_HUMAN
pepwheel	swissprot:GTR10_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GTR10_HUMAN
pepwindow	swissprot:GTR10_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GTR10_HUMAN
sigcleave	swissprot:GTR10_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GTR10_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNK5_HUMAN	Acid-sensitive potassium channel protein TASK-2
# AltName	KCNK5_HUMAN	TWIK-related acid-sensitive K(+) channel 2
# BioGrid	114197	2
# ChiTaRS	KCNK5	human
# Ensembl	ENST00000359534	ENSP00000352527; ENSG00000164626
# ExpressionAtlas	O95279	baseline and differential
# FUNCTION	KCNK5_HUMAN	pH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K(+) concentrations. 
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IEA:Ensembl.
# GO_function	GO:0005267	potassium channel activity; TAS:ProtInc.
# GO_function	GO:0022841	potassium ion leak channel activity; IBA:GO_Central.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0007588	excretion; TAS:ProtInc.
# GO_process	GO:0030322	stabilization of membrane potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Genevisible	O95279	HS
# HGNC	HGNC:6280	KCNK5
# InterPro	IPR003092	2pore_dom_K_chnl_TASK
# InterPro	IPR003280	2pore_dom_K_chnl
# InterPro	IPR013099	K_chnl_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04974	Protein digestion and absorption
# MIM	603493	gene
# MISCELLANEOUS	KCNK5_HUMAN	Inhibited by quinine, quinidine and external acidification. 
# Organism	KCNK5_HUMAN	Homo sapiens (Human)
# PRINTS	PR01095	TASKCHANNEL
# PRINTS	PR01333	2POREKCHANEL
# Pfam	PF07885	Ion_trans_2; 2
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-5576886	Phase 4 - resting membrane potential
# RecName	KCNK5_HUMAN	Potassium channel subfamily K member 5
# RefSeq	NP_003731	NM_003740.3
# SIMILARITY	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCNK5_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUBUNIT	KCNK5_HUMAN	Homodimer; disulfide-linked. 
# TCDB	1.A.1.8	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	KCNK5_HUMAN	Abundant expression in kidney, also detected in liver, placenta and small intestine. In the kidney, expression is restricted to the distal tubules and collecting ducts. Not expressed in proximal tubules or glomeruli. 
# UCSC	uc003oon	human
# eggNOG	COG1226	LUCA
# eggNOG	KOG1418	Eukaryota
BLAST	swissprot:KCNK5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNK5_HUMAN
BioCyc	ZFISH:ENSG00000164626-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000164626-MONOMER
COXPRESdb	8645	http://coxpresdb.jp/data/gene/8645.shtml
CleanEx	HS_KCNK5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNK5
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1038/bjp.2008.213	http://dx.doi.org/10.1038/bjp.2008.213
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.273.47.30863	http://dx.doi.org/10.1074/jbc.273.47.30863
DOI	10.1080/0968768031000084181	http://dx.doi.org/10.1080/0968768031000084181
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF084830	http://www.ebi.ac.uk/ena/data/view/AF084830
EMBL	AK314298	http://www.ebi.ac.uk/ena/data/view/AK314298
EMBL	AL451185	http://www.ebi.ac.uk/ena/data/view/AL451185
EMBL	BC060793	http://www.ebi.ac.uk/ena/data/view/BC060793
EMBL	BC069573	http://www.ebi.ac.uk/ena/data/view/BC069573
EMBL	CH471081	http://www.ebi.ac.uk/ena/data/view/CH471081
EMBL	EU978936	http://www.ebi.ac.uk/ena/data/view/EU978936
Ensembl	ENST00000359534	http://www.ensembl.org/id/ENST00000359534
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_function	GO:0022841	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022841
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0007588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007588
GO_process	GO:0030322	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030322
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	KCNK5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNK5
GeneID	8645	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8645
GeneTree	ENSGT00760000118858	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118858
HGNC	HGNC:6280	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6280
HOGENOM	HOG000113211	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000113211&db=HOGENOM6
HOVERGEN	HBG052236	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052236&db=HOVERGEN
HPA	HPA059148	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA059148
InParanoid	O95279	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O95279
IntAct	O95279	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O95279*
InterPro	IPR003092	http://www.ebi.ac.uk/interpro/entry/IPR003092
InterPro	IPR003280	http://www.ebi.ac.uk/interpro/entry/IPR003280
InterPro	IPR013099	http://www.ebi.ac.uk/interpro/entry/IPR013099
Jabion	8645	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=8645
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:8645	http://www.genome.jp/dbget-bin/www_bget?hsa:8645
KEGG_Orthology	KO:K04916	http://www.genome.jp/dbget-bin/www_bget?KO:K04916
KEGG_Pathway	ko04974	http://www.genome.jp/kegg-bin/show_pathway?ko04974
MIM	603493	http://www.ncbi.nlm.nih.gov/omim/603493
OMA	EQLMNEY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EQLMNEY
OrthoDB	EOG091G058Z	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G058Z
PRINTS	PR01095	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01095
PRINTS	PR01333	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01333
PSORT	swissprot:KCNK5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNK5_HUMAN
PSORT-B	swissprot:KCNK5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNK5_HUMAN
PSORT2	swissprot:KCNK5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNK5_HUMAN
Pfam	PF07885	http://pfam.xfam.org/family/PF07885
PharmGKB	PA30062	http://www.pharmgkb.org/do/serve?objId=PA30062&objCls=Gene
Phobius	swissprot:KCNK5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNK5_HUMAN
PhylomeDB	O95279	http://phylomedb.org/?seqid=O95279
ProteinModelPortal	O95279	http://www.proteinmodelportal.org/query/uniprot/O95279
PubMed	12851074	http://www.ncbi.nlm.nih.gov/pubmed/12851074
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18516069	http://www.ncbi.nlm.nih.gov/pubmed/18516069
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	9812978	http://www.ncbi.nlm.nih.gov/pubmed/9812978
Reactome	R-HSA-5576886	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576886
RefSeq	NP_003731	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003731
SMR	O95279	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O95279
STRING	9606.ENSP00000352527	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000352527&targetmode=cogs
TCDB	1.A.1.8	http://www.tcdb.org/search/result.php?tc=1.A.1.8
UCSC	uc003oon	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003oon&org=rat
UniGene	Hs.444448	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.444448
UniProtKB	KCNK5_HUMAN	http://www.uniprot.org/uniprot/KCNK5_HUMAN
UniProtKB-AC	O95279	http://www.uniprot.org/uniprot/O95279
charge	swissprot:KCNK5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNK5_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG1418	http://eggnogapi.embl.de/nog_data/html/tree/KOG1418
epestfind	swissprot:KCNK5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNK5_HUMAN
garnier	swissprot:KCNK5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNK5_HUMAN
helixturnhelix	swissprot:KCNK5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNK5_HUMAN
hmoment	swissprot:KCNK5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNK5_HUMAN
iep	swissprot:KCNK5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNK5_HUMAN
inforesidue	swissprot:KCNK5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNK5_HUMAN
neXtProt	NX_O95279	http://www.nextprot.org/db/entry/NX_O95279
octanol	swissprot:KCNK5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNK5_HUMAN
pepcoil	swissprot:KCNK5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNK5_HUMAN
pepdigest	swissprot:KCNK5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNK5_HUMAN
pepinfo	swissprot:KCNK5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNK5_HUMAN
pepnet	swissprot:KCNK5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNK5_HUMAN
pepstats	swissprot:KCNK5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNK5_HUMAN
pepwheel	swissprot:KCNK5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNK5_HUMAN
pepwindow	swissprot:KCNK5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNK5_HUMAN
sigcleave	swissprot:KCNK5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNK5_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SIDT1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NXL6-1; Sequence=Displayed; Name=2; IsoId=Q9NXL6-2; Sequence=VSP_039174; Note=No experimental confirmation available.; 
# CCDS	CCDS2974	-. [Q9NXL6-1]
# CCDS	CCDS77790	-. [Q9NXL6-2]
# ChiTaRS	SIDT1	human
# Ensembl	ENST00000264852	ENSP00000264852; ENSG00000072858. [Q9NXL6-1]
# Ensembl	ENST00000393830	ENSP00000377416; ENSG00000072858. [Q9NXL6-2]
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0051033	RNA transmembrane transporter activity; IEA:InterPro.
# GO_process	GO:0033227	dsRNA transport; IEA:InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q9NXL6	HS
# HGNC	HGNC:25967	SIDT1
# InterPro	IPR025958	SID1_TM_fam
# MIM	606816	gene
# Organism	SIDT1_HUMAN	Homo sapiens (Human)
# Pfam	PF13965	SID-1_RNA_chan
# Proteomes	UP000005640	Chromosome 3
# RecName	SIDT1_HUMAN	SID1 transmembrane family member 1
# RefSeq	NP_001295279	NM_001308350.1. [Q9NXL6-2]
# RefSeq	NP_060169	NM_017699.2. [Q9NXL6-1]
# SIMILARITY	Belongs to the SID1 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	SIDT1_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	1.A.79.1	the cholesterol uptake protein (chup) or double stranded rna uptake family
# UCSC	uc003eak	human. [Q9NXL6-1]
# eggNOG	ENOG410IF6Z	Eukaryota
# eggNOG	ENOG410XPBN	LUCA
BLAST	swissprot:SIDT1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SIDT1_HUMAN
BioCyc	ZFISH:ENSG00000072858-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000072858-MONOMER
COXPRESdb	54847	http://coxpresdb.jp/data/gene/54847.shtml
CleanEx	HS_SIDT1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SIDT1
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC055740	http://www.ebi.ac.uk/ena/data/view/AC055740
EMBL	AC112128	http://www.ebi.ac.uk/ena/data/view/AC112128
EMBL	AK000181	http://www.ebi.ac.uk/ena/data/view/AK000181
EMBL	BC117222	http://www.ebi.ac.uk/ena/data/view/BC117222
Ensembl	ENST00000264852	http://www.ensembl.org/id/ENST00000264852
Ensembl	ENST00000393830	http://www.ensembl.org/id/ENST00000393830
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0051033	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051033
GO_process	GO:0033227	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033227
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SIDT1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SIDT1
GeneID	54847	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54847
GeneTree	ENSGT00390000010091	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000010091
HGNC	HGNC:25967	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:25967
HOGENOM	HOG000020635	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000020635&db=HOGENOM6
HOVERGEN	HBG079188	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG079188&db=HOVERGEN
HPA	HPA035862	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035862
InParanoid	Q9NXL6	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NXL6
IntAct	Q9NXL6	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NXL6*
InterPro	IPR025958	http://www.ebi.ac.uk/interpro/entry/IPR025958
Jabion	54847	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=54847
KEGG_Gene	hsa:54847	http://www.genome.jp/dbget-bin/www_bget?hsa:54847
MIM	606816	http://www.ncbi.nlm.nih.gov/omim/606816
OMA	FFIQEKE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FFIQEKE
OrthoDB	EOG091G01Q2	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01Q2
PSORT	swissprot:SIDT1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SIDT1_HUMAN
PSORT-B	swissprot:SIDT1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SIDT1_HUMAN
PSORT2	swissprot:SIDT1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SIDT1_HUMAN
Pfam	PF13965	http://pfam.xfam.org/family/PF13965
PharmGKB	PA134923837	http://www.pharmgkb.org/do/serve?objId=PA134923837&objCls=Gene
Phobius	swissprot:SIDT1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SIDT1_HUMAN
PhylomeDB	Q9NXL6	http://phylomedb.org/?seqid=Q9NXL6
ProteinModelPortal	Q9NXL6	http://www.proteinmodelportal.org/query/uniprot/Q9NXL6
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
RefSeq	NP_001295279	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001295279
RefSeq	NP_060169	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060169
STRING	9606.ENSP00000264852	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000264852&targetmode=cogs
TCDB	1.A.79.1	http://www.tcdb.org/search/result.php?tc=1.A.79.1
UCSC	uc003eak	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003eak&org=rat
UniGene	Hs.591291	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.591291
UniProtKB	SIDT1_HUMAN	http://www.uniprot.org/uniprot/SIDT1_HUMAN
UniProtKB-AC	Q9NXL6	http://www.uniprot.org/uniprot/Q9NXL6
charge	swissprot:SIDT1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SIDT1_HUMAN
eggNOG	ENOG410IF6Z	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IF6Z
eggNOG	ENOG410XPBN	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPBN
epestfind	swissprot:SIDT1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SIDT1_HUMAN
garnier	swissprot:SIDT1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SIDT1_HUMAN
helixturnhelix	swissprot:SIDT1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SIDT1_HUMAN
hmoment	swissprot:SIDT1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SIDT1_HUMAN
iep	swissprot:SIDT1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SIDT1_HUMAN
inforesidue	swissprot:SIDT1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SIDT1_HUMAN
neXtProt	NX_Q9NXL6	http://www.nextprot.org/db/entry/NX_Q9NXL6
octanol	swissprot:SIDT1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SIDT1_HUMAN
pepcoil	swissprot:SIDT1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SIDT1_HUMAN
pepdigest	swissprot:SIDT1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SIDT1_HUMAN
pepinfo	swissprot:SIDT1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SIDT1_HUMAN
pepnet	swissprot:SIDT1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SIDT1_HUMAN
pepstats	swissprot:SIDT1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SIDT1_HUMAN
pepwheel	swissprot:SIDT1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SIDT1_HUMAN
pepwindow	swissprot:SIDT1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SIDT1_HUMAN
sigcleave	swissprot:SIDT1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SIDT1_HUMAN
## Database	ID	URL or Descriptions
# AltName	GTR12_HUMAN	Glucose transporter type 12
# BioGrid	127535	56
# CDD	cd06174	MFS
# ChiTaRS	SLC2A12	human
# Ensembl	ENST00000275230	ENSP00000275230; ENSG00000146411
# FUNCTION	GTR12_HUMAN	Facilitative glucose transporter. {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0012505	endomembrane system; IEA:UniProtKB-SubCell.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
# GO_function	GO:0005355	glucose transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0055056	D-glucose transmembrane transporter activity; TAS:Reactome.
# GO_function	GTR12_HUMAN	GO 0005351 sugar proton symporter activity; IBA GO_Central.
# GO_process	GO:0046323	glucose import; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q8TD20	HS
# HGNC	HGNC:18067	SLC2A12
# InterPro	IPR003663	Sugar/inositol_transpt
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR005829	Sugar_transporter_CS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	610372	gene
# Organism	GTR12_HUMAN	Homo sapiens (Human)
# PRINTS	PR00171	SUGRTRNSPORT
# PROSITE	PS00216	SUGAR_TRANSPORT_1
# PROSITE	PS50850	MFS
# PTM	GTR12_HUMAN	N-glycosylated. {ECO 0000250}. 
# Pfam	PF00083	Sugar_tr; 2
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-428790	Facilitative Na+-independent glucose transporters
# RecName	GTR12_HUMAN	Solute carrier family 2, facilitated glucose transporter member 12
# RefSeq	NP_660159	NM_145176.2
# SEQUENCE CAUTION	Sequence=BAB71214.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	GTR12_HUMAN	Endomembrane system {ECO 0000250}; Multi- pass membrane protein {ECO 0000250}. Cytoplasm, perinuclear region {ECO 0000269|PubMed 11832379}. Note=Localizes primarily perinuclear region in the absence of insulin. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.1.1.87	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	Predominantly expressed in skeletal muscle, heart and prostate, with lower levels in brain, placenta and kidney. {ECO:0000269|PubMed	11832379}. 
# UCSC	uc003qem	human
# eggNOG	ENOG410XNQK	LUCA
# eggNOG	KOG0254	Eukaryota
BLAST	swissprot:GTR12_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GTR12_HUMAN
BioCyc	ZFISH:ENSG00000146411-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000146411-MONOMER
COXPRESdb	154091	http://coxpresdb.jp/data/gene/154091.shtml
CleanEx	HS_SLC2A12	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC2A12
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AK056554	http://www.ebi.ac.uk/ena/data/view/AK056554
EMBL	AK122628	http://www.ebi.ac.uk/ena/data/view/AK122628
EMBL	AL035699	http://www.ebi.ac.uk/ena/data/view/AL035699
EMBL	AL035699	http://www.ebi.ac.uk/ena/data/view/AL035699
EMBL	AL449363	http://www.ebi.ac.uk/ena/data/view/AL449363
EMBL	AL449363	http://www.ebi.ac.uk/ena/data/view/AL449363
EMBL	AY046419	http://www.ebi.ac.uk/ena/data/view/AY046419
EMBL	BC070149	http://www.ebi.ac.uk/ena/data/view/BC070149
EMBL	CH471051	http://www.ebi.ac.uk/ena/data/view/CH471051
Ensembl	ENST00000275230	http://www.ensembl.org/id/ENST00000275230
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0012505	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0012505
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_function	GO:0005351	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005351
GO_function	GO:0005355	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005355
GO_function	GO:0055056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055056
GO_process	GO:0046323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046323
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC2A12	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC2A12
GeneID	154091	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=154091
GeneTree	ENSGT00850000132274	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00850000132274
H-InvDB	HIX0006232	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0006232
HGNC	HGNC:18067	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18067
HOGENOM	HOG000202868	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202868&db=HOGENOM6
HOVERGEN	HBG051858	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051858&db=HOVERGEN
HPA	HPA031593	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031593
InParanoid	Q8TD20	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8TD20
InterPro	IPR003663	http://www.ebi.ac.uk/interpro/entry/IPR003663
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR005829	http://www.ebi.ac.uk/interpro/entry/IPR005829
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	154091	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=154091
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:154091	http://www.genome.jp/dbget-bin/www_bget?hsa:154091
KEGG_Orthology	KO:K08149	http://www.genome.jp/dbget-bin/www_bget?KO:K08149
MIM	610372	http://www.ncbi.nlm.nih.gov/omim/610372
OMA	WTSNFAI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WTSNFAI
OrthoDB	EOG091G085H	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G085H
PRINTS	PR00171	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00171
PROSITE	PS00216	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00216
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:GTR12_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GTR12_HUMAN
PSORT-B	swissprot:GTR12_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GTR12_HUMAN
PSORT2	swissprot:GTR12_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GTR12_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
PharmGKB	PA38288	http://www.pharmgkb.org/do/serve?objId=PA38288&objCls=Gene
Phobius	swissprot:GTR12_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GTR12_HUMAN
PhylomeDB	Q8TD20	http://phylomedb.org/?seqid=Q8TD20
ProteinModelPortal	Q8TD20	http://www.proteinmodelportal.org/query/uniprot/Q8TD20
PubMed	11832379	http://www.ncbi.nlm.nih.gov/pubmed/11832379
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-428790	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428790
RefSeq	NP_660159	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_660159
SMR	Q8TD20	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8TD20
STRING	9606.ENSP00000275230	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000275230&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.1.87	http://www.tcdb.org/search/result.php?tc=2.A.1.1.87
UCSC	uc003qem	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003qem&org=rat
UniGene	Hs.486508	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.486508
UniProtKB	GTR12_HUMAN	http://www.uniprot.org/uniprot/GTR12_HUMAN
UniProtKB-AC	Q8TD20	http://www.uniprot.org/uniprot/Q8TD20
charge	swissprot:GTR12_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GTR12_HUMAN
eggNOG	ENOG410XNQK	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNQK
eggNOG	KOG0254	http://eggnogapi.embl.de/nog_data/html/tree/KOG0254
epestfind	swissprot:GTR12_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GTR12_HUMAN
garnier	swissprot:GTR12_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GTR12_HUMAN
helixturnhelix	swissprot:GTR12_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GTR12_HUMAN
hmoment	swissprot:GTR12_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GTR12_HUMAN
iep	swissprot:GTR12_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GTR12_HUMAN
inforesidue	swissprot:GTR12_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GTR12_HUMAN
neXtProt	NX_Q8TD20	http://www.nextprot.org/db/entry/NX_Q8TD20
octanol	swissprot:GTR12_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GTR12_HUMAN
pepcoil	swissprot:GTR12_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GTR12_HUMAN
pepdigest	swissprot:GTR12_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GTR12_HUMAN
pepinfo	swissprot:GTR12_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GTR12_HUMAN
pepnet	swissprot:GTR12_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GTR12_HUMAN
pepstats	swissprot:GTR12_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GTR12_HUMAN
pepwheel	swissprot:GTR12_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GTR12_HUMAN
pepwindow	swissprot:GTR12_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GTR12_HUMAN
sigcleave	swissprot:GTR12_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GTR12_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ZDH13_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8IUH4-1; Sequence=Displayed; Name=2; IsoId=Q8IUH4-2; Sequence=VSP_010029; Name=3; IsoId=Q8IUH4-3; Sequence=VSP_010028; 
# AltName	Huntingtin-interacting protein 14-related protein {ECO:0000303|PubMed	12393793}
# AltName	Huntingtin-interacting protein HIP3RP {ECO:0000312|EMBL	BAC22090.1}
# AltName	Putative MAPK-activating protein PM03 {ECO:0000312|EMBL	BAC77380.1}
# AltName	Putative NF-kappa-B-activating protein 209 {ECO:0000312|EMBL	BAC77367.1}
# AltName	Zinc finger DHHC domain-containing protein 13 {ECO:0000312|HGNC	HGNC:18413}
# BioGrid	119999	6
# CATALYTIC ACTIVITY	Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA. {ECO:0000250|UniProtKB	Q9CWU2}. 
# CCDS	CCDS44550	-. [Q8IUH4-1]
# CCDS	CCDS44551	-. [Q8IUH4-3]
# DOMAIN	ZDH13_HUMAN	The DHHC domain is required for palmitoyltransferase activity. {ECO 0000250|UniProtKB Q8IUH5}. 
# Ensembl	ENST00000399351	ENSP00000382288; ENSG00000177054. [Q8IUH4-3]
# Ensembl	ENST00000446113	ENSP00000400113; ENSG00000177054. [Q8IUH4-1]
# FUNCTION	ZDH13_HUMAN	Palmitoyltransferase for HD and GAD2. May play a role in Mg(2+) transport. {ECO 0000250|UniProtKB Q9CWU2}. 
# GO_component	GO:0000139	Golgi membrane; ISS:UniProtKB.
# GO_component	GO:0005783	endoplasmic reticulum; IDA:UniProtKB.
# GO_component	GO:0005794	Golgi apparatus; IDA:HPA.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0030659	cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0030660	Golgi-associated vesicle membrane; ISS:UniProtKB.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_function	GO:0004871	signal transducer activity; IMP:UniProtKB.
# GO_function	GO:0008270	zinc ion binding; IEA:InterPro.
# GO_function	GO:0015095	magnesium ion transmembrane transporter activity; ISS:UniProtKB.
# GO_function	GO:0016409	palmitoyltransferase activity; ISS:UniProtKB.
# GO_function	GO:0019706	protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
# GO_process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0016746	transferase activity, transferring acyl groups
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.25.40.20	-; 1.
# Genevisible	Q8IUH4	HS
# HGNC	HGNC:18413	ZDHHC13
# InterPro	IPR001594	Znf_DHHC_palmitoyltrfase
# InterPro	IPR002110	Ankyrin_rpt
# InterPro	IPR020683	Ankyrin_rpt-contain_dom
# InterPro	IPR030290	ZDHHC13
# MIM	612815	gene
# Organism	ZDH13_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR24161:SF16	PTHR24161:SF16
# PROSITE	PS50088	ANK_REPEAT; 4
# PROSITE	PS50216	DHHC
# PROSITE	PS50297	ANK_REP_REGION
# Pfam	PF01529	zf-DHHC
# Pfam	PF12796	Ank_2
# Proteomes	UP000005640	Chromosome 11
# RecName	Palmitoyltransferase ZDHHC13 {ECO	0000305}
# RefSeq	NP_001001483	NM_001001483.2. [Q8IUH4-3]
# RefSeq	NP_061901	NM_019028.2. [Q8IUH4-1]
# RefSeq	XP_005253053	XM_005252996.2. [Q8IUH4-3]
# RefSeq	XP_011518497	XM_011520195.1. [Q8IUH4-3]
# SEQUENCE CAUTION	Sequence=BAA91856.1; Type=Erroneous termination; Positions=482; Note=Translated as Cys.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 DHHC domain. {ECO:0000255|PROSITE- ProRule	PRU00067}. 
# SIMILARITY	Contains 7 ANK repeats. {ECO:0000255|PROSITE- ProRule	PRU00023}. 
# SMART	SM00248	ANK; 6
# SUBCELLULAR LOCATION	ZDH13_HUMAN	Golgi apparatus membrane {ECO 0000250|UniProtKB Q9CWU2}; Multi-pass membrane protein {ECO 0000255}. Cytoplasmic vesicle membrane {ECO 0000250|UniProtKB Q9CWU2}; Multi-pass membrane protein {ECO 0000255}. Note=Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi vesicles. {ECO 0000250|UniProtKB Q9CWU2}. 
# SUBUNIT	ZDH13_HUMAN	Interacts (via ANK repeats) with CLIP3 (PubMed 26198635). Interacts (via ANK repeats) with DNAJC5 (via C-terminus) (By similarity). Interacts (via ANK repeats) with HTT (PubMed 26198635). Interacts (via ANK repeats) with MAP6 (PubMed 26198635). Interacts (via ANK repeats) with SNAP23 (By similarity). Interacts (via ANK repeats) with SNAP25 (By similarity). {ECO 0000250|UniProtKB Q9CWU2, ECO 0000269|PubMed 26198635}. 
# SUPFAM	SSF48403	SSF48403
# TCDB	9.B.37.3	the huntington-interacting protein 14 (hip14) family
# UCSC	uc001mpi	human. [Q8IUH4-1]
# eggNOG	COG0666	LUCA
# eggNOG	COG5273	LUCA
# eggNOG	KOG0509	Eukaryota
BLAST	swissprot:ZDH13_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ZDH13_HUMAN
COXPRESdb	54503	http://coxpresdb.jp/data/gene/54503.shtml
CleanEx	HS_ZDHHC13	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ZDHHC13
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.onc.1206406	http://dx.doi.org/10.1038/sj.onc.1206406
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1074/jbc.M115.657668	http://dx.doi.org/10.1074/jbc.M115.657668
DOI	10.1093/hmg/11.23.2815	http://dx.doi.org/10.1093/hmg/11.23.2815
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EC_number	EC:2.3.1.225 {ECO:0000250|UniProtKB:Q9CWU2}	http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.225 {ECO:0000250|UniProtKB:Q9CWU2}
EMBL	AB024495	http://www.ebi.ac.uk/ena/data/view/AB024495
EMBL	AB097014	http://www.ebi.ac.uk/ena/data/view/AB097014
EMBL	AB097027	http://www.ebi.ac.uk/ena/data/view/AB097027
EMBL	AC009652	http://www.ebi.ac.uk/ena/data/view/AC009652
EMBL	AK001714	http://www.ebi.ac.uk/ena/data/view/AK001714
EMBL	AK001831	http://www.ebi.ac.uk/ena/data/view/AK001831
EMBL	BC036020	http://www.ebi.ac.uk/ena/data/view/BC036020
EMBL	BC050690	http://www.ebi.ac.uk/ena/data/view/BC050690
EMBL	BC056152	http://www.ebi.ac.uk/ena/data/view/BC056152
ENZYME	2.3.1.225 {ECO:0000250|UniProtKB:Q9CWU2}	http://enzyme.expasy.org/EC/2.3.1.225 {ECO:0000250|UniProtKB:Q9CWU2}
Ensembl	ENST00000399351	http://www.ensembl.org/id/ENST00000399351
Ensembl	ENST00000446113	http://www.ensembl.org/id/ENST00000446113
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030659
GO_component	GO:0030660	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030660
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GO_function	GO:0008270	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270
GO_function	GO:0015095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015095
GO_function	GO:0016409	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016409
GO_function	GO:0019706	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019706
GO_process	GO:0043123	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043123
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0016746	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.25.40.20	http://www.cathdb.info/version/latest/superfamily/1.25.40.20
GeneCards	ZDHHC13	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ZDHHC13
GeneID	54503	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54503
GeneTree	ENSGT00530000063074	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063074
HGNC	HGNC:18413	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18413
HOGENOM	HOG000290181	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000290181&db=HOGENOM6
HOVERGEN	HBG051907	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051907&db=HOVERGEN
HPA	HPA016759	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA016759
HPA	HPA018791	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA018791
InParanoid	Q8IUH4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8IUH4
IntEnz	2.3.1.225 {ECO:0000250|UniProtKB:Q9CWU2}	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.225 {ECO:0000250|UniProtKB:Q9CWU2}
InterPro	IPR001594	http://www.ebi.ac.uk/interpro/entry/IPR001594
InterPro	IPR002110	http://www.ebi.ac.uk/interpro/entry/IPR002110
InterPro	IPR020683	http://www.ebi.ac.uk/interpro/entry/IPR020683
InterPro	IPR030290	http://www.ebi.ac.uk/interpro/entry/IPR030290
Jabion	54503	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=54503
KEGG_Gene	hsa:54503	http://www.genome.jp/dbget-bin/www_bget?hsa:54503
MIM	612815	http://www.ncbi.nlm.nih.gov/omim/612815
OMA	HCATTFR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HCATTFR
OrthoDB	EOG091G056H	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G056H
PANTHER	PTHR24161:SF16	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24161:SF16
PROSITE	PS50088	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50088
PROSITE	PS50216	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50216
PROSITE	PS50297	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50297
PSORT	swissprot:ZDH13_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ZDH13_HUMAN
PSORT-B	swissprot:ZDH13_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ZDH13_HUMAN
PSORT2	swissprot:ZDH13_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ZDH13_HUMAN
Pfam	PF01529	http://pfam.xfam.org/family/PF01529
Pfam	PF12796	http://pfam.xfam.org/family/PF12796
PharmGKB	PA134955878	http://www.pharmgkb.org/do/serve?objId=PA134955878&objCls=Gene
Phobius	swissprot:ZDH13_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ZDH13_HUMAN
PhylomeDB	Q8IUH4	http://phylomedb.org/?seqid=Q8IUH4
ProteinModelPortal	Q8IUH4	http://www.proteinmodelportal.org/query/uniprot/Q8IUH4
PubMed	12393793	http://www.ncbi.nlm.nih.gov/pubmed/12393793
PubMed	12761501	http://www.ncbi.nlm.nih.gov/pubmed/12761501
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	26198635	http://www.ncbi.nlm.nih.gov/pubmed/26198635
RefSeq	NP_001001483	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001001483
RefSeq	NP_061901	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061901
RefSeq	XP_005253053	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005253053
RefSeq	XP_011518497	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011518497
SMART	SM00248	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00248
SMR	Q8IUH4	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8IUH4
STRING	9606.ENSP00000400113	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000400113&targetmode=cogs
SUPFAM	SSF48403	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48403
TCDB	9.B.37.3	http://www.tcdb.org/search/result.php?tc=9.B.37.3
UCSC	uc001mpi	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001mpi&org=rat
UniGene	Hs.188569	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.188569
UniProtKB	ZDH13_HUMAN	http://www.uniprot.org/uniprot/ZDH13_HUMAN
UniProtKB-AC	Q8IUH4	http://www.uniprot.org/uniprot/Q8IUH4
charge	swissprot:ZDH13_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ZDH13_HUMAN
eggNOG	COG0666	http://eggnogapi.embl.de/nog_data/html/tree/COG0666
eggNOG	COG5273	http://eggnogapi.embl.de/nog_data/html/tree/COG5273
eggNOG	KOG0509	http://eggnogapi.embl.de/nog_data/html/tree/KOG0509
epestfind	swissprot:ZDH13_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ZDH13_HUMAN
garnier	swissprot:ZDH13_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ZDH13_HUMAN
helixturnhelix	swissprot:ZDH13_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZDH13_HUMAN
hmoment	swissprot:ZDH13_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ZDH13_HUMAN
iep	swissprot:ZDH13_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ZDH13_HUMAN
inforesidue	swissprot:ZDH13_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ZDH13_HUMAN
neXtProt	NX_Q8IUH4	http://www.nextprot.org/db/entry/NX_Q8IUH4
octanol	swissprot:ZDH13_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ZDH13_HUMAN
pepcoil	swissprot:ZDH13_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ZDH13_HUMAN
pepdigest	swissprot:ZDH13_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ZDH13_HUMAN
pepinfo	swissprot:ZDH13_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ZDH13_HUMAN
pepnet	swissprot:ZDH13_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ZDH13_HUMAN
pepstats	swissprot:ZDH13_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ZDH13_HUMAN
pepwheel	swissprot:ZDH13_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ZDH13_HUMAN
pepwindow	swissprot:ZDH13_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ZDH13_HUMAN
sigcleave	swissprot:ZDH13_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ZDH13_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	VATC2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8NEY4-1; Sequence=Displayed; Name=2; IsoId=Q8NEY4-2; Sequence=VSP_024883; 
# AltName	VATC2_HUMAN	Vacuolar proton pump subunit C 2
# BioGrid	128859	24
# CCDS	CCDS1674	-. [Q8NEY4-2]
# CCDS	CCDS42653	-. [Q8NEY4-1]
# CDD	cd14785	V-ATPase_C
# ChiTaRS	ATP6V1C2	human
# Ensembl	ENST00000272238	ENSP00000272238; ENSG00000143882. [Q8NEY4-1]
# Ensembl	ENST00000381661	ENSP00000371077; ENSG00000143882. [Q8NEY4-2]
# ExpressionAtlas	Q8NEY4	baseline and differential
# FUNCTION	VATC2_HUMAN	Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. 
# GO_component	GO:0000221	vacuolar proton-transporting V-type ATPase, V1 domain; IBA:GO_Central.
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism; IBA:GO_Central.
# GO_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
# GO_function	GO:0046983	protein dimerization activity; IDA:UniProtKB.
# GO_process	GO:0008286	insulin receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0015991	ATP hydrolysis coupled proton transport; IEA:InterPro.
# GO_process	GO:0016241	regulation of macroautophagy; NAS:ParkinsonsUK-UCL.
# GO_process	GO:0030177	positive regulation of Wnt signaling pathway; IMP:UniProtKB.
# GO_process	GO:0033572	transferrin transport; TAS:Reactome.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0090383	phagosome acidification; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q8NEY4	HS
# HGNC	HGNC:18264	ATP6V1C2
# INTERACTION	VATC2_HUMAN	Q08379 GOLGA2; NbExp=3; IntAct=EBI-10270867, EBI-618309; 
# IntAct	Q8NEY4	16
# InterPro	IPR004907	ATPase_V1-cplx_csu
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04966	Collecting duct acid secretion
# KEGG_Pathway	ko05110	Vibrio cholerae infection
# KEGG_Pathway	ko05120	Epithelial cell signaling in Helicobacter pylori infection
# KEGG_Pathway	ko05323	Rheumatoid arthritis
# Organism	VATC2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10137	PTHR10137; 2
# Pfam	PF03223	V-ATPase_C
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-1222556	ROS, RNS production in response to bacteria
# Reactome	R-HSA-77387	Insulin receptor recycling
# Reactome	R-HSA-917977	Transferrin endocytosis and recycling
# Reactome	R-HSA-983712	Ion channel transport
# RecName	VATC2_HUMAN	V-type proton ATPase subunit C 2
# RefSeq	NP_001034451	NM_001039362.1. [Q8NEY4-1]
# RefSeq	NP_653184	NM_144583.3. [Q8NEY4-2]
# RefSeq	XP_016859234	XM_017003745.1. [Q8NEY4-1]
# SEQUENCE CAUTION	Sequence=AAY24069.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the V-ATPase C subunit family. {ECO	0000305}. 
# SUBUNIT	V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components	 a, c, c', c'' and d). 
# SUPFAM	SSF118203	SSF118203; 2
# TCDB	3.A.2.2	the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily
# TISSUE SPECIFICITY	Kidney and placenta. {ECO:0000269|PubMed	12384298}. 
# UCSC	uc002ras	human. [Q8NEY4-1]
# eggNOG	COG5127	LUCA
# eggNOG	KOG2909	Eukaryota
BLAST	swissprot:VATC2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VATC2_HUMAN
BioCyc	MetaCyc:HS07123-MONOMER	http://biocyc.org/getid?id=MetaCyc:HS07123-MONOMER
BioCyc	ZFISH:HS07123-MONOMER	http://biocyc.org/getid?id=ZFISH:HS07123-MONOMER
COXPRESdb	245973	http://coxpresdb.jp/data/gene/245973.shtml
CleanEx	HS_ATP6V1C2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP6V1C2
DOI	10.1016/S0378-1119(02)00884-3	http://dx.doi.org/10.1016/S0378-1119(02)00884-3
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC092687	http://www.ebi.ac.uk/ena/data/view/AC092687
EMBL	AY039759	http://www.ebi.ac.uk/ena/data/view/AY039759
EMBL	BC012142	http://www.ebi.ac.uk/ena/data/view/BC012142
Ensembl	ENST00000272238	http://www.ensembl.org/id/ENST00000272238
Ensembl	ENST00000381661	http://www.ensembl.org/id/ENST00000381661
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000221	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000221
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0008553	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008553
GO_function	GO:0046961	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046961
GO_function	GO:0046983	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046983
GO_process	GO:0008286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008286
GO_process	GO:0015991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015991
GO_process	GO:0016241	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016241
GO_process	GO:0030177	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030177
GO_process	GO:0033572	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033572
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0090383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090383
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ATP6V1C2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP6V1C2
GeneID	245973	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=245973
GeneTree	ENSGT00390000004263	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000004263
HGNC	HGNC:18264	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18264
HOGENOM	HOG000207528	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000207528&db=HOGENOM6
HOVERGEN	HBG002470	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG002470&db=HOVERGEN
HPA	HPA034734	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA034734
HPA	HPA034735	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA034735
InParanoid	Q8NEY4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8NEY4
IntAct	Q8NEY4	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8NEY4*
InterPro	IPR004907	http://www.ebi.ac.uk/interpro/entry/IPR004907
Jabion	245973	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=245973
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:245973	http://www.genome.jp/dbget-bin/www_bget?hsa:245973
KEGG_Orthology	KO:K02148	http://www.genome.jp/dbget-bin/www_bget?KO:K02148
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04966	http://www.genome.jp/kegg-bin/show_pathway?ko04966
KEGG_Pathway	ko05110	http://www.genome.jp/kegg-bin/show_pathway?ko05110
KEGG_Pathway	ko05120	http://www.genome.jp/kegg-bin/show_pathway?ko05120
KEGG_Pathway	ko05323	http://www.genome.jp/kegg-bin/show_pathway?ko05323
OMA	NSEYLIT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NSEYLIT
OrthoDB	EOG091G03CP	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G03CP
PANTHER	PTHR10137	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10137
PSORT	swissprot:VATC2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VATC2_HUMAN
PSORT-B	swissprot:VATC2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VATC2_HUMAN
PSORT2	swissprot:VATC2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VATC2_HUMAN
Pfam	PF03223	http://pfam.xfam.org/family/PF03223
PharmGKB	PA38514	http://www.pharmgkb.org/do/serve?objId=PA38514&objCls=Gene
Phobius	swissprot:VATC2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VATC2_HUMAN
PhylomeDB	Q8NEY4	http://phylomedb.org/?seqid=Q8NEY4
ProteinModelPortal	Q8NEY4	http://www.proteinmodelportal.org/query/uniprot/Q8NEY4
PubMed	12384298	http://www.ncbi.nlm.nih.gov/pubmed/12384298
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
Reactome	R-HSA-1222556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1222556
Reactome	R-HSA-77387	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-77387
Reactome	R-HSA-917977	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917977
Reactome	R-HSA-983712	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983712
RefSeq	NP_001034451	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001034451
RefSeq	NP_653184	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_653184
RefSeq	XP_016859234	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016859234
SMR	Q8NEY4	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8NEY4
STRING	9606.ENSP00000272238	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000272238&targetmode=cogs
SUPFAM	SSF118203	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF118203
TCDB	3.A.2.2	http://www.tcdb.org/search/result.php?tc=3.A.2.2
UCSC	uc002ras	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ras&org=rat
UniGene	Hs.580464	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.580464
UniProtKB	VATC2_HUMAN	http://www.uniprot.org/uniprot/VATC2_HUMAN
UniProtKB-AC	Q8NEY4	http://www.uniprot.org/uniprot/Q8NEY4
charge	swissprot:VATC2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VATC2_HUMAN
eggNOG	COG5127	http://eggnogapi.embl.de/nog_data/html/tree/COG5127
eggNOG	KOG2909	http://eggnogapi.embl.de/nog_data/html/tree/KOG2909
epestfind	swissprot:VATC2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VATC2_HUMAN
garnier	swissprot:VATC2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VATC2_HUMAN
helixturnhelix	swissprot:VATC2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VATC2_HUMAN
hmoment	swissprot:VATC2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VATC2_HUMAN
iep	swissprot:VATC2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VATC2_HUMAN
inforesidue	swissprot:VATC2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VATC2_HUMAN
neXtProt	NX_Q8NEY4	http://www.nextprot.org/db/entry/NX_Q8NEY4
octanol	swissprot:VATC2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VATC2_HUMAN
pepcoil	swissprot:VATC2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VATC2_HUMAN
pepdigest	swissprot:VATC2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VATC2_HUMAN
pepinfo	swissprot:VATC2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VATC2_HUMAN
pepnet	swissprot:VATC2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VATC2_HUMAN
pepstats	swissprot:VATC2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VATC2_HUMAN
pepwheel	swissprot:VATC2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VATC2_HUMAN
pepwindow	swissprot:VATC2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VATC2_HUMAN
sigcleave	swissprot:VATC2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VATC2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ZDH17_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8IUH5-1; Sequence=Displayed; Name=2; IsoId=Q8IUH5-2; Sequence=VSP_010021, VSP_010022, VSP_010024, VSP_010025; Name=3; IsoId=Q8IUH5-3; Sequence=VSP_010023; Note=No experimental confirmation available.; 
# AltName	Huntingtin yeast partner H {ECO:0000303|PubMed	9700202}
# AltName	Huntingtin-interacting protein 14 {ECO:0000303|PubMed	15489887}
# AltName	Huntingtin-interacting protein 3 {ECO:0000312|EMBL	BAC22089.1}
# AltName	Huntingtin-interacting protein H {ECO:0000303|PubMed	9700202}
# AltName	Putative MAPK-activating protein PM11 {ECO:0000305|PubMed	12761501}
# AltName	Putative NF-kappa-B-activating protein 205 {ECO:0000305|PubMed	12761501}
# AltName	Zinc finger DHHC domain-containing protein 17 {ECO:0000312|HGNC	HGNC:18412}
# BRENDA	2.3.1.225	2681
# BioGrid	116965	241
# CATALYTIC ACTIVITY	ZDH17_HUMAN	Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA. {ECO 0000269|PubMed 15489887, ECO 0000269|PubMed 15603740}. 
# CCDS	CCDS44946	-. [Q8IUH5-1]
# ChiTaRS	ZDHHC17	human
# DOMAIN	ZDH17_HUMAN	The DHHC domain is required for palmitoyltransferase activity. {ECO 0000269|PubMed 15603740}. 
# Ensembl	ENST00000426126	ENSP00000403397; ENSG00000186908. [Q8IUH5-1]
# ExpressionAtlas	Q8IUH5	baseline and differential
# FUNCTION	ZDH17_HUMAN	Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD (PubMed 15603740, PubMed 15489887, PubMed 19139280). Palmitoylates MPP1 in erythrocytes (PubMed 22496366). May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane (PubMed 12393793). May play a role in Mg(2+) transport (PubMed 18794299). {ECO 0000269|PubMed 12393793, ECO 0000269|PubMed 15489887, ECO 0000269|PubMed 15603740, ECO 0000269|PubMed 18794299, ECO 0000269|PubMed 19139280, ECO 0000269|PubMed 22496366}. 
# GO_component	GO:0000139	Golgi membrane; IDA:UniProtKB.
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0005794	Golgi apparatus; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030659	cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0030660	Golgi-associated vesicle membrane; IDA:UniProtKB.
# GO_component	GO:0042734	presynaptic membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_function	GO:0004871	signal transducer activity; IMP:UniProtKB.
# GO_function	GO:0008270	zinc ion binding; IEA:InterPro.
# GO_function	GO:0015095	magnesium ion transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0016409	palmitoyltransferase activity; IDA:UniProtKB.
# GO_function	GO:0019706	protein-cysteine S-palmitoyltransferase activity; IDA:UniProtKB.
# GO_function	GO:0042802	identical protein binding; IPI:IntAct.
# GO_process	GO:0018345	protein palmitoylation; IDA:UniProtKB.
# GO_process	GO:0042953	lipoprotein transport; IDA:UniProtKB.
# GO_process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0016746	transferase activity, transferring acyl groups
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.25.40.20	-; 1.
# Genevisible	Q8IUH5	HS
# HGNC	HGNC:18412	ZDHHC17
# INTERACTION	ZDH17_HUMAN	Self; NbExp=6; IntAct=EBI-524753, EBI-524753; Q7Z783 -; NbExp=3; IntAct=EBI-524753, EBI-9088990; Q7Z5R6 APBB1IP; NbExp=2; IntAct=EBI-524753, EBI-2818084; Q9NP61 ARFGAP3; NbExp=2; IntAct=EBI-524753, EBI-2875816; P15336 ATF2; NbExp=3; IntAct=EBI-524753, EBI-1170906; Q9UQB8-3 BAIAP2; NbExp=3; IntAct=EBI-524753, EBI-9091996; Q9UQB8-6 BAIAP2; NbExp=2; IntAct=EBI-524753, EBI-9092016; P17655 CAPN2; NbExp=2; IntAct=EBI-524753, EBI-1028956; Q96GN5-2 CDCA7L; NbExp=2; IntAct=EBI-524753, EBI-9091443; P48730-2 CSNK1D; NbExp=3; IntAct=EBI-524753, EBI-9087876; P68104 EEF1A1; NbExp=2; IntAct=EBI-524753, EBI-352162; P60228 EIF3E; NbExp=2; IntAct=EBI-524753, EBI-347740; Q9UI08-2 EVL; NbExp=2; IntAct=EBI-524753, EBI-6448852; Q9UHY8 FEZ2; NbExp=4; IntAct=EBI-524753, EBI-396453; Q08379 GOLGA2; NbExp=3; IntAct=EBI-524753, EBI-618309; Q9H4A5 GOLPH3L; NbExp=2; IntAct=EBI-524753, EBI-4403434; P51674 GPM6A; NbExp=5; IntAct=EBI-524753, EBI-7187133; P49840 GSK3A; NbExp=3; IntAct=EBI-524753, EBI-1044067; P42858 HTT; NbExp=12; IntAct=EBI-524753, EBI-466029; Q8IY31-3 IFT20; NbExp=3; IntAct=EBI-524753, EBI-9091197; Q9NWB7 IFT57; NbExp=2; IntAct=EBI-524753, EBI-725672; O60259 KLK8; NbExp=3; IntAct=EBI-524753, EBI-3915857; Q14847-2 LASP1; NbExp=3; IntAct=EBI-524753, EBI-9088686; Q96CV9-2 OPTN; NbExp=2; IntAct=EBI-524753, EBI-9091423; Q08499-8 PDE4D; NbExp=2; IntAct=EBI-524753, EBI-9090666; O15530-4 PDPK1; NbExp=3; IntAct=EBI-524753, EBI-9087775; P27986-2 PIK3R1; NbExp=2; IntAct=EBI-524753, EBI-9090282; Q9UF11-4 PLEKHB1; NbExp=4; IntAct=EBI-524753, EBI-9089825; Q16537 PPP2R5E; NbExp=2; IntAct=EBI-524753, EBI-968374; Q96DA2 RAB39B; NbExp=3; IntAct=EBI-524753, EBI-9089467; Q15047-2 SETDB1; NbExp=3; IntAct=EBI-524753, EBI-9090795; Q8IVB4 SLC9A9; NbExp=2; IntAct=EBI-524753, EBI-9092184; O00161 SNAP23; NbExp=4; IntAct=EBI-524753, EBI-745000; P60880 SNAP25; NbExp=3; IntAct=EBI-524753, EBI-524785; Q7Z699 SPRED1; NbExp=3; IntAct=EBI-524753, EBI-5235340; Q7Z698 SPRED2; NbExp=3; IntAct=EBI-524753, EBI-7082156; O43597 SPRY2; NbExp=3; IntAct=EBI-524753, EBI-742487; Q9C004 SPRY4; NbExp=2; IntAct=EBI-524753, EBI-354861; Q8NFA0 USP32; NbExp=2; IntAct=EBI-524753, EBI-2511075; Q9Y6W5 WASF2; NbExp=2; IntAct=EBI-524753, EBI-4290615; 
# IntAct	Q8IUH5	226
# InterPro	IPR001594	Znf_DHHC_palmitoyltrfase
# InterPro	IPR002110	Ankyrin_rpt
# InterPro	IPR020683	Ankyrin_rpt-contain_dom
# InterPro	IPR030289	ZDHHC17
# MIM	607799	gene
# Organism	ZDH17_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR24161:SF18	PTHR24161:SF18
# PDB	3EU9	X-ray; 1.99 A; A/B/C=51-288
# PRINTS	PR01415	ANKYRIN
# PROSITE	PS50088	ANK_REPEAT; 5
# PROSITE	PS50216	DHHC
# PROSITE	PS50297	ANK_REP_REGION
# PTM	ZDH17_HUMAN	Autopalmitoylated (PubMed 15603740, PubMed 18794299). Autopalmitoylation has a regulatory role in ZDHHC17-mediated Mg(2+) transport (PubMed 18794299). {ECO 0000269|PubMed 15603740, ECO 0000269|PubMed 18794299}. 
# Pfam	PF01529	zf-DHHC
# Pfam	PF12796	Ank_2; 2
# Proteomes	UP000005640	Chromosome 12
# RecName	Palmitoyltransferase ZDHHC17 {ECO	0000305}
# RefSeq	NP_056151	NM_015336.2. [Q8IUH5-1]
# SEQUENCE CAUTION	ZDH17_HUMAN	Sequence=AAF28972.1; Type=Frameshift; Positions=183, 191; Evidence={ECO 0000305}; Sequence=AAH30990.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=BAA76790.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=BAC77366.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=BAC77388.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305};
# SIMILARITY	Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 DHHC domain. {ECO:0000255|PROSITE- ProRule	PRU00067}. 
# SIMILARITY	ZDH17_HUMAN	Contains 7 ANK repeats. {ECO 0000255|PROSITE- ProRule PRU00023, ECO 0000305|PubMed 25547411}. 
# SMART	SM00248	ANK; 5
# SUBCELLULAR LOCATION	ZDH17_HUMAN	Golgi apparatus membrane {ECO 0000269|PubMed 15603740, ECO 0000269|PubMed 18794299}; Multi- pass membrane protein {ECO 0000255}. Cytoplasmic vesicle membrane {ECO 0000269|PubMed 18794299}; Multi-pass membrane protein {ECO 0000255}. Cell junction, synapse, presynaptic cell membrane {ECO 0000269|PubMed 18032660}; Multi-pass membrane protein {ECO 0000255}. Note=Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi membrane vesicles. {ECO 0000269|PubMed 18794299}. 
# SUBUNIT	ZDH17_HUMAN	Interacts (via ANK repeats) with CLIP3 (PubMed 26198635). Interacts (via ANK repeats) with HTT; this interaction is inversely correlated to the length of the polyglutamine tract added to the huntingtin protein in Huntington disease (PubMed 12393793, PubMed 9700202, PubMed 26198635). Interacts (via ANK repeats) with DNAJC5 (via C-terminus) (By similarity). Interacts (via ANK repeats) with MAP6 (PubMed 26198635). Interacts (via ANK repeats) with SNAP23 (By similarity). Interacts (via ANK repeats) with SNAP25 (By similarity). {ECO 0000250|UniProtKB Q80TN5, ECO 0000269|PubMed 12393793, ECO 0000269|PubMed 26198635, ECO 0000269|PubMed 9700202}. 
# SUPFAM	SSF48403	SSF48403
# TCDB	9.B.37.1	the huntington-interacting protein 14 (hip14) family
# TISSUE SPECIFICITY	ZDH17_HUMAN	Expressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital lobe and caudate and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney. ZDHHC17 is the only palmitoyltransferase in erythrocytes. {ECO 0000269|PubMed 12393793, ECO 0000269|PubMed 22496366}. 
# UCSC	uc001syk	human. [Q8IUH5-1]
# eggNOG	COG0666	LUCA
# eggNOG	COG5273	LUCA
# eggNOG	KOG0509	Eukaryota
BLAST	swissprot:ZDH17_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ZDH17_HUMAN
COXPRESdb	23390	http://coxpresdb.jp/data/gene/23390.shtml
CleanEx	HS_ZDHHC17	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ZDHHC17
DOI	10.1002/prot.22452	http://dx.doi.org/10.1002/prot.22452
DOI	10.1016/j.neuron.2004.11.027	http://dx.doi.org/10.1016/j.neuron.2004.11.027
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.onc.1206406	http://dx.doi.org/10.1038/sj.onc.1206406
DOI	10.1038/sj.onc.1208171	http://dx.doi.org/10.1038/sj.onc.1208171
DOI	10.1074/jbc.M111.332981	http://dx.doi.org/10.1074/jbc.M111.332981
DOI	10.1074/jbc.M115.657668	http://dx.doi.org/10.1074/jbc.M115.657668
DOI	10.1074/jbc.M801469200	http://dx.doi.org/10.1074/jbc.M801469200
DOI	10.1093/dnares/6.1.63	http://dx.doi.org/10.1093/dnares/6.1.63
DOI	10.1093/hmg/11.23.2815	http://dx.doi.org/10.1093/hmg/11.23.2815
DOI	10.1093/hmg/7.9.1463	http://dx.doi.org/10.1093/hmg/7.9.1463
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1128/MCB.00754-08	http://dx.doi.org/10.1128/MCB.00754-08
DOI	10.1186/s12859-014-0440-9	http://dx.doi.org/10.1186/s12859-014-0440-9
DOI	10.1523/JNEUROSCI.2464-07.2007	http://dx.doi.org/10.1523/JNEUROSCI.2464-07.2007
EC_number	EC:2.3.1.225 {ECO:0000269|PubMed:15489887, ECO:0000269|PubMed:15603740}	http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.225 {ECO:0000269|PubMed:15489887, ECO:0000269|PubMed:15603740}
EMBL	AB023163	http://www.ebi.ac.uk/ena/data/view/AB023163
EMBL	AB024494	http://www.ebi.ac.uk/ena/data/view/AB024494
EMBL	AB097013	http://www.ebi.ac.uk/ena/data/view/AB097013
EMBL	AB097035	http://www.ebi.ac.uk/ena/data/view/AB097035
EMBL	AF049612	http://www.ebi.ac.uk/ena/data/view/AF049612
EMBL	AF161412	http://www.ebi.ac.uk/ena/data/view/AF161412
EMBL	AK299089	http://www.ebi.ac.uk/ena/data/view/AK299089
EMBL	BC030990	http://www.ebi.ac.uk/ena/data/view/BC030990
EMBL	BC050324	http://www.ebi.ac.uk/ena/data/view/BC050324
ENZYME	2.3.1.225 {ECO:0000269|PubMed:15489887, ECO:0000269|PubMed:15603740}	http://enzyme.expasy.org/EC/2.3.1.225 {ECO:0000269|PubMed:15489887, ECO:0000269|PubMed:15603740}
Ensembl	ENST00000426126	http://www.ensembl.org/id/ENST00000426126
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030659
GO_component	GO:0030660	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030660
GO_component	GO:0042734	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042734
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GO_function	GO:0008270	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270
GO_function	GO:0015095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015095
GO_function	GO:0016409	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016409
GO_function	GO:0019706	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019706
GO_function	GO:0042802	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802
GO_process	GO:0018345	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018345
GO_process	GO:0042953	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042953
GO_process	GO:0043123	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043123
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0016746	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.25.40.20	http://www.cathdb.info/version/latest/superfamily/1.25.40.20
GeneCards	ZDHHC17	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ZDHHC17
GeneID	23390	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23390
GeneTree	ENSGT00530000063074	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063074
HGNC	HGNC:18412	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18412
HOVERGEN	HBG051907	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051907&db=HOVERGEN
HPA	HPA016807	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA016807
InParanoid	Q8IUH5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8IUH5
IntAct	Q8IUH5	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8IUH5*
IntEnz	2.3.1.225 {ECO:0000269|PubMed:15489887, ECO:0000269|PubMed:15603740}	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.225 {ECO:0000269|PubMed:15489887, ECO:0000269|PubMed:15603740}
InterPro	IPR001594	http://www.ebi.ac.uk/interpro/entry/IPR001594
InterPro	IPR002110	http://www.ebi.ac.uk/interpro/entry/IPR002110
InterPro	IPR020683	http://www.ebi.ac.uk/interpro/entry/IPR020683
InterPro	IPR030289	http://www.ebi.ac.uk/interpro/entry/IPR030289
Jabion	23390	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=23390
KEGG_Gene	hsa:23390	http://www.genome.jp/dbget-bin/www_bget?hsa:23390
MIM	607799	http://www.ncbi.nlm.nih.gov/omim/607799
MINT	MINT-1537511	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1537511
OMA	IMQLARI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IMQLARI
OrthoDB	EOG091G056H	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G056H
PANTHER	PTHR24161:SF18	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24161:SF18
PDB	3EU9	http://www.ebi.ac.uk/pdbe-srv/view/entry/3EU9
PDBsum	3EU9	http://www.ebi.ac.uk/pdbsum/3EU9
PRINTS	PR01415	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01415
PROSITE	PS50088	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50088
PROSITE	PS50216	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50216
PROSITE	PS50297	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50297
PSORT	swissprot:ZDH17_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ZDH17_HUMAN
PSORT-B	swissprot:ZDH17_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ZDH17_HUMAN
PSORT2	swissprot:ZDH17_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ZDH17_HUMAN
Pfam	PF01529	http://pfam.xfam.org/family/PF01529
Pfam	PF12796	http://pfam.xfam.org/family/PF12796
PharmGKB	PA134991292	http://www.pharmgkb.org/do/serve?objId=PA134991292&objCls=Gene
Phobius	swissprot:ZDH17_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ZDH17_HUMAN
PhylomeDB	Q8IUH5	http://phylomedb.org/?seqid=Q8IUH5
ProteinModelPortal	Q8IUH5	http://www.proteinmodelportal.org/query/uniprot/Q8IUH5
PubMed	10231032	http://www.ncbi.nlm.nih.gov/pubmed/10231032
PubMed	12393793	http://www.ncbi.nlm.nih.gov/pubmed/12393793
PubMed	12761501	http://www.ncbi.nlm.nih.gov/pubmed/12761501
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15489887	http://www.ncbi.nlm.nih.gov/pubmed/15489887
PubMed	15603740	http://www.ncbi.nlm.nih.gov/pubmed/15603740
PubMed	18032660	http://www.ncbi.nlm.nih.gov/pubmed/18032660
PubMed	18794299	http://www.ncbi.nlm.nih.gov/pubmed/18794299
PubMed	19139280	http://www.ncbi.nlm.nih.gov/pubmed/19139280
PubMed	19434754	http://www.ncbi.nlm.nih.gov/pubmed/19434754
PubMed	22496366	http://www.ncbi.nlm.nih.gov/pubmed/22496366
PubMed	25547411	http://www.ncbi.nlm.nih.gov/pubmed/25547411
PubMed	26198635	http://www.ncbi.nlm.nih.gov/pubmed/26198635
PubMed	9700202	http://www.ncbi.nlm.nih.gov/pubmed/9700202
RefSeq	NP_056151	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_056151
SMART	SM00248	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00248
SMR	Q8IUH5	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8IUH5
STRING	9606.ENSP00000403397	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000403397&targetmode=cogs
SUPFAM	SSF48403	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48403
TCDB	9.B.37.1	http://www.tcdb.org/search/result.php?tc=9.B.37.1
UCSC	uc001syk	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001syk&org=rat
UniGene	Hs.4014	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.4014
UniProtKB	ZDH17_HUMAN	http://www.uniprot.org/uniprot/ZDH17_HUMAN
UniProtKB-AC	Q8IUH5	http://www.uniprot.org/uniprot/Q8IUH5
charge	swissprot:ZDH17_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ZDH17_HUMAN
eggNOG	COG0666	http://eggnogapi.embl.de/nog_data/html/tree/COG0666
eggNOG	COG5273	http://eggnogapi.embl.de/nog_data/html/tree/COG5273
eggNOG	KOG0509	http://eggnogapi.embl.de/nog_data/html/tree/KOG0509
epestfind	swissprot:ZDH17_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ZDH17_HUMAN
garnier	swissprot:ZDH17_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ZDH17_HUMAN
helixturnhelix	swissprot:ZDH17_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZDH17_HUMAN
hmoment	swissprot:ZDH17_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ZDH17_HUMAN
iep	swissprot:ZDH17_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ZDH17_HUMAN
inforesidue	swissprot:ZDH17_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ZDH17_HUMAN
neXtProt	NX_Q8IUH5	http://www.nextprot.org/db/entry/NX_Q8IUH5
octanol	swissprot:ZDH17_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ZDH17_HUMAN
pepcoil	swissprot:ZDH17_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ZDH17_HUMAN
pepdigest	swissprot:ZDH17_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ZDH17_HUMAN
pepinfo	swissprot:ZDH17_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ZDH17_HUMAN
pepnet	swissprot:ZDH17_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ZDH17_HUMAN
pepstats	swissprot:ZDH17_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ZDH17_HUMAN
pepwheel	swissprot:ZDH17_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ZDH17_HUMAN
pepwindow	swissprot:ZDH17_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ZDH17_HUMAN
sigcleave	swissprot:ZDH17_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ZDH17_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	M2OM_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q02978-1; Sequence=Displayed; Name=2; IsoId=Q02978-2; Sequence=VSP_046745; Note=Gene prediction based on EST data.; 
# AltName	M2OM_HUMAN	Solute carrier family 25 member 11
# BioGrid	113990	52
# CCDS	CCDS11059	-. [Q02978-1]
# CCDS	CCDS54069	-. [Q02978-2]
# ChiTaRS	SLC25A11	human
# Ensembl	ENST00000225665	ENSP00000225665; ENSG00000108528. [Q02978-1]
# Ensembl	ENST00000544061	ENSP00000440804; ENSG00000108528. [Q02978-2]
# ExpressionAtlas	Q02978	baseline and differential
# FUNCTION	M2OM_HUMAN	Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism. 
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_function	GO:0044822	poly(A) RNA binding; IDA:UniProtKB.
# GO_function	M2OM_HUMAN	GO 0015367 oxoglutarate malate antiporter activity; TAS Reactome.
# GO_process	GO:0006006	glucose metabolic process; TAS:Reactome.
# GO_process	GO:0006094	gluconeogenesis; TAS:Reactome.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005739	mitochondrion
# GOslim_function	GO:0003723	RNA binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0005975	carbohydrate metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0044281	small molecule metabolic process
# Gene3D	1.50.40.10	-; 1.
# Genevisible	Q02978	HS
# HGNC	HGNC:10981	SLC25A11
# IntAct	Q02978	18
# InterPro	IPR018108	Mitochondrial_sb/sol_carrier
# InterPro	IPR023395	Mt_carrier_dom
# KEGG_Brite	ko02001	Solute carrier family
# MIM	604165	gene
# Organism	M2OM_HUMAN	Homo sapiens (Human)
# PIR	A56650	A56650
# PROSITE	PS50920	SOLCAR; 3
# Pfam	PF00153	Mito_carr; 3
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-70263	Gluconeogenesis
# Reactome	R-HSA-70326	Glucose metabolism
# RecName	M2OM_HUMAN	Mitochondrial 2-oxoglutarate/malate carrier protein
# RefSeq	NP_003553	NM_003562.4. [Q02978-1]
# SIMILARITY	Belongs to the mitochondrial carrier (TC 2.A.29) family. {ECO	0000305}. 
# SIMILARITY	Contains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule	PRU00282}.
# SUBCELLULAR LOCATION	M2OM_HUMAN	Mitochondrion inner membrane; Multi-pass membrane protein. 
# SUPFAM	SSF103506	SSF103506
# TCDB	2.A.29.2.13	the mitochondrial carrier (mc) family
# TopDownProteomics	Q02978-1	-. [Q02978-1]
# UCSC	uc021toe	human. [Q02978-1]
# eggNOG	ENOG410XQHU	LUCA
# eggNOG	KOG0759	Eukaryota
BLAST	swissprot:M2OM_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:M2OM_HUMAN
BioCyc	ZFISH:ENSG00000108528-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000108528-MONOMER
COXPRESdb	8402	http://coxpresdb.jp/data/gene/8402.shtml
CleanEx	HS_SLC25A11	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC25A11
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1074/mcp.M111.015131	http://dx.doi.org/10.1074/mcp.M111.015131
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AC004771	http://www.ebi.ac.uk/ena/data/view/AC004771
EMBL	AF070548	http://www.ebi.ac.uk/ena/data/view/AF070548
EMBL	BC006508	http://www.ebi.ac.uk/ena/data/view/BC006508
EMBL	BC006519	http://www.ebi.ac.uk/ena/data/view/BC006519
EMBL	BC016294	http://www.ebi.ac.uk/ena/data/view/BC016294
EMBL	BC017170	http://www.ebi.ac.uk/ena/data/view/BC017170
EMBL	X66114	http://www.ebi.ac.uk/ena/data/view/X66114
Ensembl	ENST00000225665	http://www.ensembl.org/id/ENST00000225665
Ensembl	ENST00000544061	http://www.ensembl.org/id/ENST00000544061
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0015367	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015367
GO_function	GO:0044822	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044822
GO_process	GO:0006006	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006006
GO_process	GO:0006094	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006094
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_function	GO:0003723	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
Gene3D	1.50.40.10	http://www.cathdb.info/version/latest/superfamily/1.50.40.10
GeneCards	SLC25A11	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC25A11
GeneID	8402	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8402
GeneTree	ENSGT00760000119170	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119170
HGNC	HGNC:10981	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10981
HOGENOM	HOG000165139	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000165139&db=HOGENOM6
HOVERGEN	HBG009528	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG009528&db=HOVERGEN
HPA	HPA021167	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA021167
InParanoid	Q02978	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q02978
IntAct	Q02978	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q02978*
InterPro	IPR018108	http://www.ebi.ac.uk/interpro/entry/IPR018108
InterPro	IPR023395	http://www.ebi.ac.uk/interpro/entry/IPR023395
Jabion	8402	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=8402
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:8402	http://www.genome.jp/dbget-bin/www_bget?hsa:8402
KEGG_Orthology	KO:K15104	http://www.genome.jp/dbget-bin/www_bget?KO:K15104
MIM	604165	http://www.ncbi.nlm.nih.gov/omim/604165
MINT	MINT-1161051	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1161051
OMA	SDNIFCH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SDNIFCH
OrthoDB	EOG091G0BQ7	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0BQ7
PROSITE	PS50920	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50920
PSORT	swissprot:M2OM_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:M2OM_HUMAN
PSORT-B	swissprot:M2OM_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:M2OM_HUMAN
PSORT2	swissprot:M2OM_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:M2OM_HUMAN
Pfam	PF00153	http://pfam.xfam.org/family/PF00153
PharmGKB	PA35857	http://www.pharmgkb.org/do/serve?objId=PA35857&objCls=Gene
Phobius	swissprot:M2OM_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:M2OM_HUMAN
PhylomeDB	Q02978	http://phylomedb.org/?seqid=Q02978
ProteinModelPortal	Q02978	http://www.proteinmodelportal.org/query/uniprot/Q02978
PubMed	1457818	http://www.ncbi.nlm.nih.gov/pubmed/1457818
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22223895	http://www.ncbi.nlm.nih.gov/pubmed/22223895
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-70263	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-70263
Reactome	R-HSA-70326	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-70326
RefSeq	NP_003553	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003553
STRING	9606.ENSP00000225665	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000225665&targetmode=cogs
SUPFAM	SSF103506	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103506
TCDB	2.A.29.2.13	http://www.tcdb.org/search/result.php?tc=2.A.29.2.13
UCSC	uc021toe	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc021toe&org=rat
UniGene	Hs.184877	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.184877
UniProtKB	M2OM_HUMAN	http://www.uniprot.org/uniprot/M2OM_HUMAN
UniProtKB-AC	Q02978	http://www.uniprot.org/uniprot/Q02978
charge	swissprot:M2OM_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:M2OM_HUMAN
eggNOG	ENOG410XQHU	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQHU
eggNOG	KOG0759	http://eggnogapi.embl.de/nog_data/html/tree/KOG0759
epestfind	swissprot:M2OM_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:M2OM_HUMAN
garnier	swissprot:M2OM_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:M2OM_HUMAN
helixturnhelix	swissprot:M2OM_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:M2OM_HUMAN
hmoment	swissprot:M2OM_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:M2OM_HUMAN
iep	swissprot:M2OM_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:M2OM_HUMAN
inforesidue	swissprot:M2OM_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:M2OM_HUMAN
neXtProt	NX_Q02978	http://www.nextprot.org/db/entry/NX_Q02978
octanol	swissprot:M2OM_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:M2OM_HUMAN
pepcoil	swissprot:M2OM_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:M2OM_HUMAN
pepdigest	swissprot:M2OM_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:M2OM_HUMAN
pepinfo	swissprot:M2OM_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:M2OM_HUMAN
pepnet	swissprot:M2OM_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:M2OM_HUMAN
pepstats	swissprot:M2OM_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:M2OM_HUMAN
pepwheel	swissprot:M2OM_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:M2OM_HUMAN
pepwindow	swissprot:M2OM_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:M2OM_HUMAN
sigcleave	swissprot:M2OM_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:M2OM_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	COG2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14746-1; Sequence=Displayed; Name=2; IsoId=Q14746-2; Sequence=VSP_042942; Note=No experimental confirmation available.; 
# AltName	COG2_HUMAN	Component of oligomeric Golgi complex 2
# AltName	COG2_HUMAN	Low density lipoprotein receptor defect C-complementing protein
# BioGrid	116477	29
# CCDS	CCDS1584	-. [Q14746-1]
# CCDS	CCDS44329	-. [Q14746-2]
# Ensembl	ENST00000366668	ENSP00000355628; ENSG00000135775. [Q14746-2]
# Ensembl	ENST00000366669	ENSP00000355629; ENSG00000135775. [Q14746-1]
# ExpressionAtlas	Q14746	baseline and differential
# FUNCTION	COG2_HUMAN	Required for normal Golgi morphology and function. 
# GO_component	GO:0000139	Golgi membrane; TAS:Reactome.
# GO_component	GO:0005795	Golgi stack; IDA:UniProtKB.
# GO_component	GO:0005829	cytosol; IEA:Ensembl.
# GO_component	GO:0017119	Golgi transport complex; IDA:UniProtKB.
# GO_component	GO:0032588	trans-Golgi network membrane; TAS:Reactome.
# GO_function	GO:0008565	protein transporter activity; IMP:UniProtKB.
# GO_process	GO:0006888	ER to Golgi vesicle-mediated transport; TAS:Reactome.
# GO_process	GO:0006891	intra-Golgi vesicle-mediated transport; IMP:UniProtKB.
# GO_process	GO:0007030	Golgi organization; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# Genevisible	Q14746	HS
# HGNC	HGNC:6546	COG2
# INTERACTION	COG2_HUMAN	Q9H9E3 COG4; NbExp=2; IntAct=EBI-389449, EBI-368382; Q5JR59 MTUS2; NbExp=3; IntAct=EBI-10233912, EBI-742948; 
# IntAct	Q14746	15
# InterPro	IPR009316	COG2
# InterPro	IPR024602	COG_su2_N
# InterPro	IPR024603	COG_complex_COG2_C
# MIM	606974	gene
# Organism	COG2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12961	PTHR12961; 2
# PIR	A53542	A53542
# Pfam	PF06148	COG2
# Pfam	PF12022	DUF3510
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-6807878	COPI-mediated anterograde transport
# Reactome	R-HSA-6811438	Intra-Golgi traffic
# Reactome	R-HSA-6811440	Retrograde transport at the Trans-Golgi-Network
# RecName	COG2_HUMAN	Conserved oligomeric Golgi complex subunit 2
# RefSeq	NP_001138508	NM_001145036.1. [Q14746-2]
# RefSeq	NP_031383	NM_007357.2. [Q14746-1]
# SIMILARITY	Belongs to the COG2 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	COG2_HUMAN	Golgi apparatus membrane {ECO 0000305}; Peripheral membrane protein {ECO 0000305}; Cytoplasmic side {ECO 0000305}. 
# SUBUNIT	COG2_HUMAN	Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. 
# TopDownProteomics	Q14746-1	-. [Q14746-1]
# UCSC	uc001htw	human. [Q14746-1]
# eggNOG	ENOG410XU2D	LUCA
# eggNOG	KOG2307	Eukaryota
BLAST	swissprot:COG2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:COG2_HUMAN
BioCyc	ZFISH:ENSG00000135775-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000135775-MONOMER
COXPRESdb	22796	http://coxpresdb.jp/data/gene/22796.shtml
CleanEx	HS_COG2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_COG2
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1083/jcb.127.3.679	http://dx.doi.org/10.1083/jcb.127.3.679
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AL158214	http://www.ebi.ac.uk/ena/data/view/AL158214
EMBL	BC014960	http://www.ebi.ac.uk/ena/data/view/BC014960
EMBL	BC051906	http://www.ebi.ac.uk/ena/data/view/BC051906
EMBL	CH471098	http://www.ebi.ac.uk/ena/data/view/CH471098
EMBL	Z34975	http://www.ebi.ac.uk/ena/data/view/Z34975
Ensembl	ENST00000366668	http://www.ensembl.org/id/ENST00000366668
Ensembl	ENST00000366669	http://www.ensembl.org/id/ENST00000366669
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005795	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005795
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0017119	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017119
GO_component	GO:0032588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032588
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0006888	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006888
GO_process	GO:0006891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006891
GO_process	GO:0007030	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007030
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GeneCards	COG2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=COG2
GeneID	22796	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22796
GeneTree	ENSGT00390000012040	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000012040
HGNC	HGNC:6546	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6546
HOGENOM	HOG000046032	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000046032&db=HOGENOM6
HOVERGEN	HBG030902	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG030902&db=HOVERGEN
InParanoid	Q14746	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q14746
IntAct	Q14746	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q14746*
InterPro	IPR009316	http://www.ebi.ac.uk/interpro/entry/IPR009316
InterPro	IPR024602	http://www.ebi.ac.uk/interpro/entry/IPR024602
InterPro	IPR024603	http://www.ebi.ac.uk/interpro/entry/IPR024603
Jabion	22796	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=22796
KEGG_Gene	hsa:22796	http://www.genome.jp/dbget-bin/www_bget?hsa:22796
MIM	606974	http://www.ncbi.nlm.nih.gov/omim/606974
OMA	LQSGHKD	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LQSGHKD
OrthoDB	EOG091G05GZ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05GZ
PANTHER	PTHR12961	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12961
PSORT	swissprot:COG2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:COG2_HUMAN
PSORT-B	swissprot:COG2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:COG2_HUMAN
PSORT2	swissprot:COG2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:COG2_HUMAN
Pfam	PF06148	http://pfam.xfam.org/family/PF06148
Pfam	PF12022	http://pfam.xfam.org/family/PF12022
PharmGKB	PA26697	http://www.pharmgkb.org/do/serve?objId=PA26697&objCls=Gene
Phobius	swissprot:COG2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:COG2_HUMAN
PhylomeDB	Q14746	http://phylomedb.org/?seqid=Q14746
ProteinModelPortal	Q14746	http://www.proteinmodelportal.org/query/uniprot/Q14746
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	7962052	http://www.ncbi.nlm.nih.gov/pubmed/7962052
Reactome	R-HSA-6807878	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6807878
Reactome	R-HSA-6811438	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6811438
Reactome	R-HSA-6811440	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6811440
RefSeq	NP_001138508	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001138508
RefSeq	NP_031383	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_031383
SMR	Q14746	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q14746
STRING	9606.ENSP00000355629	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000355629&targetmode=cogs
UCSC	uc001htw	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001htw&org=rat
UniGene	Hs.211800	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.211800
UniProtKB	COG2_HUMAN	http://www.uniprot.org/uniprot/COG2_HUMAN
UniProtKB-AC	Q14746	http://www.uniprot.org/uniprot/Q14746
charge	swissprot:COG2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:COG2_HUMAN
eggNOG	ENOG410XU2D	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XU2D
eggNOG	KOG2307	http://eggnogapi.embl.de/nog_data/html/tree/KOG2307
epestfind	swissprot:COG2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:COG2_HUMAN
garnier	swissprot:COG2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:COG2_HUMAN
helixturnhelix	swissprot:COG2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:COG2_HUMAN
hmoment	swissprot:COG2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:COG2_HUMAN
iep	swissprot:COG2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:COG2_HUMAN
inforesidue	swissprot:COG2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:COG2_HUMAN
neXtProt	NX_Q14746	http://www.nextprot.org/db/entry/NX_Q14746
octanol	swissprot:COG2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:COG2_HUMAN
pepcoil	swissprot:COG2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:COG2_HUMAN
pepdigest	swissprot:COG2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:COG2_HUMAN
pepinfo	swissprot:COG2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:COG2_HUMAN
pepnet	swissprot:COG2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:COG2_HUMAN
pepstats	swissprot:COG2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:COG2_HUMAN
pepwheel	swissprot:COG2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:COG2_HUMAN
pepwindow	swissprot:COG2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:COG2_HUMAN
sigcleave	swissprot:COG2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:COG2_HUMAN
## Database	ID	URL or Descriptions
# AltName	AT5G3_HUMAN	ATP synthase lipid-binding protein
# AltName	AT5G3_HUMAN	ATP synthase proteolipid P3
# AltName	AT5G3_HUMAN	ATP synthase proton-transporting mitochondrial F(0) complex subunit C3
# AltName	AT5G3_HUMAN	ATPase protein 9
# AltName	AT5G3_HUMAN	ATPase subunit c
# BioGrid	107003	9
# ChiTaRS	ATP5G3	human
# Ensembl	ENST00000284727	ENSP00000284727; ENSG00000154518
# Ensembl	ENST00000392541	ENSP00000376324; ENSG00000154518
# Ensembl	ENST00000409194	ENSP00000387317; ENSG00000154518
# FUNCTION	AT5G3_HUMAN	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element. 
# GO_component	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); IBA:GO_Central.
# GO_component	GO:0005741	mitochondrial outer membrane; TAS:Reactome.
# GO_component	GO:0005753	mitochondrial proton-transporting ATP synthase complex; TAS:ProtInc.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005215	transporter activity; NAS:ProtInc.
# GO_function	GO:0008289	lipid binding; IEA:UniProtKB-KW.
# GO_function	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism; IBA:GO_Central.
# GO_process	GO:0006754	ATP biosynthetic process; TAS:Reactome.
# GO_process	GO:0015986	ATP synthesis coupled proton transport; IBA:GO_Central.
# GO_process	GO:0015991	ATP hydrolysis coupled proton transport; IEA:InterPro.
# GO_process	GO:0042776	mitochondrial ATP synthesis coupled proton transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008289	lipid binding
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.20.10	-; 1.
# Genevisible	P48201	HS
# HAMAP	MF_01396	ATP_synth_c_bact
# HGNC	HGNC:843	ATP5G3
# InterPro	IPR000454	ATP_synth_F0_csu
# InterPro	IPR002379	ATPase_proteolipid_c-like_dom
# InterPro	IPR020537	ATP_synth_F0_csu_DDCD_BS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	602736	gene
# MISCELLANEOUS	AT5G3_HUMAN	There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins. Is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease). 
# Organism	AT5G3_HUMAN	Homo sapiens (Human)
# PIR	I38612	I38612
# PRINTS	PR00124	ATPASEC
# PROSITE	PS00605	ATPASE_C
# Pfam	PF00137	ATP-synt_C
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-163210	Formation of ATP by chemiosmotic coupling
# RecName	AT5G3_HUMAN	ATP synthase F(0) complex subunit C3, mitochondrial
# RefSeq	NP_001002258	NM_001002258.4
# RefSeq	NP_001680	NM_001689.4
# SIMILARITY	Belongs to the ATPase C chain family. {ECO	0000305}.
# SUBCELLULAR LOCATION	AT5G3_HUMAN	Mitochondrion membrane; Multi-pass membrane protein. 
# SUBUNIT	F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits	 a, b and c. 
# SUPFAM	SSF81333	SSF81333
# UCSC	uc002ujz	human
# eggNOG	COG0636	LUCA
# eggNOG	KOG3025	Eukaryota
BLAST	swissprot:AT5G3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AT5G3_HUMAN
BioCyc	ZFISH:ENSG00000154518-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000154518-MONOMER
COG	COG0636	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0636
COXPRESdb	518	http://coxpresdb.jp/data/gene/518.shtml
CleanEx	HS_ATP5G3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP5G3
DOI	10.1006/geno.1994.1631	http://dx.doi.org/10.1006/geno.1994.1631
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC096649	http://www.ebi.ac.uk/ena/data/view/AC096649
EMBL	AK311999	http://www.ebi.ac.uk/ena/data/view/AK311999
EMBL	BC106881	http://www.ebi.ac.uk/ena/data/view/BC106881
EMBL	CH471058	http://www.ebi.ac.uk/ena/data/view/CH471058
EMBL	CH471058	http://www.ebi.ac.uk/ena/data/view/CH471058
EMBL	U09813	http://www.ebi.ac.uk/ena/data/view/U09813
Ensembl	ENST00000284727	http://www.ensembl.org/id/ENST00000284727
Ensembl	ENST00000392541	http://www.ensembl.org/id/ENST00000392541
Ensembl	ENST00000409194	http://www.ensembl.org/id/ENST00000409194
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000276
GO_component	GO:0005741	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005741
GO_component	GO:0005753	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005753
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GO_function	GO:0046933	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046933
GO_process	GO:0006754	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006754
GO_process	GO:0015986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015986
GO_process	GO:0015991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015991
GO_process	GO:0042776	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042776
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.20.10	http://www.cathdb.info/version/latest/superfamily/1.20.20.10
GeneCards	ATP5G3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP5G3
GeneID	518	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=518
GeneTree	ENSGT00390000006210	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000006210
HAMAP	MF_01396	http://hamap.expasy.org/unirule/MF_01396
HGNC	HGNC:843	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:843
HOGENOM	HOG000235246	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000235246&db=HOGENOM6
HOVERGEN	HBG050605	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050605&db=HOVERGEN
InParanoid	P48201	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P48201
IntAct	P48201	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P48201*
InterPro	IPR000454	http://www.ebi.ac.uk/interpro/entry/IPR000454
InterPro	IPR002379	http://www.ebi.ac.uk/interpro/entry/IPR002379
InterPro	IPR020537	http://www.ebi.ac.uk/interpro/entry/IPR020537
Jabion	518	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=518
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:518	http://www.genome.jp/dbget-bin/www_bget?hsa:518
KEGG_Orthology	KO:K02128	http://www.genome.jp/dbget-bin/www_bget?KO:K02128
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	602736	http://www.ncbi.nlm.nih.gov/omim/602736
MINT	MINT-1036155	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1036155
OMA	CKMFACA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CKMFACA
OrthoDB	EOG091G13J1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G13J1
PRINTS	PR00124	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00124
PROSITE	PS00605	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00605
PSORT	swissprot:AT5G3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AT5G3_HUMAN
PSORT-B	swissprot:AT5G3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AT5G3_HUMAN
PSORT2	swissprot:AT5G3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AT5G3_HUMAN
Pfam	PF00137	http://pfam.xfam.org/family/PF00137
PharmGKB	PA25133	http://www.pharmgkb.org/do/serve?objId=PA25133&objCls=Gene
Phobius	swissprot:AT5G3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AT5G3_HUMAN
PhylomeDB	P48201	http://phylomedb.org/?seqid=P48201
ProteinModelPortal	P48201	http://www.proteinmodelportal.org/query/uniprot/P48201
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	7698763	http://www.ncbi.nlm.nih.gov/pubmed/7698763
Reactome	R-HSA-163210	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-163210
RefSeq	NP_001002258	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001002258
RefSeq	NP_001680	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001680
STRING	9606.ENSP00000284727	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000284727&targetmode=cogs
STRING	COG0636	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0636&targetmode=cogs
SUPFAM	SSF81333	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81333
UCSC	uc002ujz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ujz&org=rat
UniGene	Hs.429	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.429
UniProtKB	AT5G3_HUMAN	http://www.uniprot.org/uniprot/AT5G3_HUMAN
UniProtKB-AC	P48201	http://www.uniprot.org/uniprot/P48201
charge	swissprot:AT5G3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AT5G3_HUMAN
eggNOG	COG0636	http://eggnogapi.embl.de/nog_data/html/tree/COG0636
eggNOG	KOG3025	http://eggnogapi.embl.de/nog_data/html/tree/KOG3025
epestfind	swissprot:AT5G3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AT5G3_HUMAN
garnier	swissprot:AT5G3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AT5G3_HUMAN
helixturnhelix	swissprot:AT5G3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AT5G3_HUMAN
hmoment	swissprot:AT5G3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AT5G3_HUMAN
iep	swissprot:AT5G3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AT5G3_HUMAN
inforesidue	swissprot:AT5G3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AT5G3_HUMAN
neXtProt	NX_P48201	http://www.nextprot.org/db/entry/NX_P48201
octanol	swissprot:AT5G3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AT5G3_HUMAN
pepcoil	swissprot:AT5G3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AT5G3_HUMAN
pepdigest	swissprot:AT5G3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AT5G3_HUMAN
pepinfo	swissprot:AT5G3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AT5G3_HUMAN
pepnet	swissprot:AT5G3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AT5G3_HUMAN
pepstats	swissprot:AT5G3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AT5G3_HUMAN
pepwheel	swissprot:AT5G3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AT5G3_HUMAN
pepwindow	swissprot:AT5G3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AT5G3_HUMAN
sigcleave	swissprot:AT5G3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AT5G3_HUMAN
## Database	ID	URL or Descriptions
# AltName	VATB1_HUMAN	Endomembrane proton pump 58 kDa subunit
# AltName	VATB1_HUMAN	Vacuolar proton pump subunit B 1
# BioGrid	107008	93
# DISEASE	VATB1_HUMAN	Renal tubular acidosis, distal, with progressive nerve deafness (dRTA-D) [MIM 267300]  An autosomal recessive disease characterized by the association of renal distal tubular acidosis with sensorineural hearing loss. Distal renal tubular acidosis is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis. It is due to functional failure of alpha- intercalated cells of the cortical collecting duct of the distal nephron, where vectorial proton transport is required for urinary acidification. {ECO 0000269|PubMed 12414817, ECO 0000269|PubMed 12579397, ECO 0000269|PubMed 9916796}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	VATB1_HUMAN	The PDZ-binding motif mediates interactions with SLC9A3R1 and SCL4A7. {ECO 0000269|PubMed 12444018}. 
# Ensembl	ENST00000234396	ENSP00000234396; ENSG00000116039
# ExpressionAtlas	P15313	baseline and differential
# FUNCTION	VATB1_HUMAN	Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. 
# GO_component	GO:0005737	cytoplasm; ISS:UniProtKB.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0005902	microvillus; ISS:UniProtKB.
# GO_component	GO:0012505	endomembrane system; IEA:UniProtKB-SubCell.
# GO_component	GO:0016323	basolateral plasma membrane; ISS:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016328	lateral plasma membrane; ISS:UniProtKB.
# GO_component	GO:0016471	vacuolar proton-transporting V-type ATPase complex; IMP:HGNC.
# GO_component	GO:0033180	proton-transporting V-type ATPase, V1 domain; IEA:InterPro.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005524	ATP binding; IEA:InterPro.
# GO_function	GO:0015078	hydrogen ion transmembrane transporter activity; ISS:UniProtKB.
# GO_function	GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances; IEA:InterPro.
# GO_process	GO:0001503	ossification; IMP:HGNC.
# GO_process	GO:0006885	regulation of pH; IMP:HGNC.
# GO_process	GO:0007588	excretion; IMP:UniProtKB.
# GO_process	GO:0007605	sensory perception of sound; IMP:UniProtKB.
# GO_process	GO:0008286	insulin receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0015991	ATP hydrolysis coupled proton transport; IEA:InterPro.
# GO_process	GO:0015992	proton transport; IMP:HGNC.
# GO_process	GO:0016241	regulation of macroautophagy; NAS:ParkinsonsUK-UCL.
# GO_process	GO:0033572	transferrin transport; TAS:Reactome.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0042472	inner ear morphogenesis; IMP:UniProtKB.
# GO_process	GO:0045851	pH reduction; IMP:UniProtKB.
# GO_process	GO:0046034	ATP metabolic process; IEA:InterPro.
# GO_process	GO:0055074	calcium ion homeostasis; IMP:UniProtKB.
# GO_process	GO:0090383	phagosome acidification; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 1.
# Genevisible	P15313	HS
# HAMAP	MF_00310	ATP_synth_B_arch
# HGNC	HGNC:853	ATP6V1B1
# IntAct	P15313	5
# InterPro	IPR000194	ATPase_F1/V1/A1_a/bsu_nucl-bd
# InterPro	IPR004100	ATPase_F1/V1/A1_a/bsu_N
# InterPro	IPR005723	ATPase_V1-cplx_bsu
# InterPro	IPR020003	ATPase_a/bsu_AS
# InterPro	IPR022879	V-ATPase_su_B/beta
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Disease	H00428	[Urinary system disease] Distal renal tubular acidosis (RTA type 1)
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04966	Collecting duct acid secretion
# KEGG_Pathway	ko05110	Vibrio cholerae infection
# KEGG_Pathway	ko05120	Epithelial cell signaling in Helicobacter pylori infection
# KEGG_Pathway	ko05323	Rheumatoid arthritis
# MIM	192132	gene
# MIM	267300	phenotype
# Organism	VATB1_HUMAN	Homo sapiens (Human)
# Orphanet	402041	Autosomal recessive distal renal tubular acidosis
# PIR	A33281	A33281
# PIRSF	PIRSF039114	V-ATPsynth_beta/V-ATPase_B
# PROSITE	PS00152	ATPASE_ALPHA_BETA
# Pfam	PF00006	ATP-synt_ab
# Pfam	PF02874	ATP-synt_ab_N
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-1222556	ROS, RNS production in response to bacteria
# Reactome	R-HSA-77387	Insulin receptor recycling
# Reactome	R-HSA-917977	Transferrin endocytosis and recycling
# Reactome	R-HSA-983712	Ion channel transport
# RecName	VATB1_HUMAN	V-type proton ATPase subunit B, kidney isoform
# RefSeq	NP_001683	NM_001692.3
# SEQUENCE CAUTION	Sequence=AAA36498.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the ATPase alpha/beta chains family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	VATB1_HUMAN	Endomembrane system; Peripheral membrane protein. Note=Endomembrane. 
# SUBUNIT	V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component	 the proteolipid protein). Forms a complex with SLC9A3R1 and SCL4A7. 
# SUPFAM	SSF52540	SSF52540
# TCDB	3.A.2.2	the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily
# TIGRFAMs	TIGR01040	V-ATPase_V1_B
# TISSUE SPECIFICITY	Expressed in the cochlea and endolymphatic sac. {ECO:0000269|PubMed	9916796}. 
# UCSC	uc002shj	human
# eggNOG	COG1156	LUCA
# eggNOG	KOG1351	Eukaryota
BLAST	swissprot:VATB1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VATB1_HUMAN
BioCyc	MetaCyc:HS03975-MONOMER	http://biocyc.org/getid?id=MetaCyc:HS03975-MONOMER
BioCyc	ZFISH:HS03975-MONOMER	http://biocyc.org/getid?id=ZFISH:HS03975-MONOMER
COG	COG1156	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1156
COXPRESdb	525	http://coxpresdb.jp/data/gene/525.shtml
CleanEx	HS_ATP6V1B1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP6V1B1
DOI	10.1007/s00467-002-1018-8	http://dx.doi.org/10.1007/s00467-002-1018-8
DOI	10.1038/5022	http://dx.doi.org/10.1038/5022
DOI	10.1038/nature19057	http://dx.doi.org/10.1038/nature19057
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.86.16.6067	http://dx.doi.org/10.1073/pnas.86.16.6067
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1136/jmg.39.11.796	http://dx.doi.org/10.1136/jmg.39.11.796
DOI	10.1152/ajpcell.00225.2002	http://dx.doi.org/10.1152/ajpcell.00225.2002
EMBL	AK223151	http://www.ebi.ac.uk/ena/data/view/AK223151
EMBL	AK291121	http://www.ebi.ac.uk/ena/data/view/AK291121
EMBL	AK313194	http://www.ebi.ac.uk/ena/data/view/AK313194
EMBL	BC063411	http://www.ebi.ac.uk/ena/data/view/BC063411
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
EMBL	M25809	http://www.ebi.ac.uk/ena/data/view/M25809
Ensembl	ENST00000234396	http://www.ensembl.org/id/ENST00000234396
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005902
GO_component	GO:0012505	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0012505
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0016328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016328
GO_component	GO:0016471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016471
GO_component	GO:0033180	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033180
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0015078	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015078
GO_function	GO:0016820	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016820
GO_process	GO:0001503	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001503
GO_process	GO:0006885	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006885
GO_process	GO:0007588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007588
GO_process	GO:0007605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007605
GO_process	GO:0008286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008286
GO_process	GO:0015991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015991
GO_process	GO:0015992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992
GO_process	GO:0016241	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016241
GO_process	GO:0033572	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033572
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0042472	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042472
GO_process	GO:0045851	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045851
GO_process	GO:0046034	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046034
GO_process	GO:0055074	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055074
GO_process	GO:0090383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090383
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ATP6V1B1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP6V1B1
GeneID	525	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=525
GeneTree	ENSGT00550000074724	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074724
HAMAP	MF_00310	http://hamap.expasy.org/unirule/MF_00310
HGNC	HGNC:853	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:853
HOGENOM	HOG000165320	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000165320&db=HOGENOM6
HOVERGEN	HBG002176	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG002176&db=HOVERGEN
HPA	CAB009523	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB009523
HPA	HPA031847	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031847
InParanoid	P15313	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P15313
IntAct	P15313	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P15313*
InterPro	IPR000194	http://www.ebi.ac.uk/interpro/entry/IPR000194
InterPro	IPR004100	http://www.ebi.ac.uk/interpro/entry/IPR004100
InterPro	IPR005723	http://www.ebi.ac.uk/interpro/entry/IPR005723
InterPro	IPR020003	http://www.ebi.ac.uk/interpro/entry/IPR020003
InterPro	IPR022879	http://www.ebi.ac.uk/interpro/entry/IPR022879
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	525	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=525
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Disease	H00428	http://www.genome.jp/dbget-bin/www_bget?H00428
KEGG_Gene	hsa:525	http://www.genome.jp/dbget-bin/www_bget?hsa:525
KEGG_Orthology	KO:K02147	http://www.genome.jp/dbget-bin/www_bget?KO:K02147
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04966	http://www.genome.jp/kegg-bin/show_pathway?ko04966
KEGG_Pathway	ko05110	http://www.genome.jp/kegg-bin/show_pathway?ko05110
KEGG_Pathway	ko05120	http://www.genome.jp/kegg-bin/show_pathway?ko05120
KEGG_Pathway	ko05323	http://www.genome.jp/kegg-bin/show_pathway?ko05323
MIM	192132	http://www.ncbi.nlm.nih.gov/omim/192132
MIM	267300	http://www.ncbi.nlm.nih.gov/omim/267300
MINT	MINT-8417607	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8417607
OMA	GIDSQKT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GIDSQKT
Orphanet	402041	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=402041
OrthoDB	EOG091G04TR	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G04TR
PROSITE	PS00152	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00152
PSORT	swissprot:VATB1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VATB1_HUMAN
PSORT-B	swissprot:VATB1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VATB1_HUMAN
PSORT2	swissprot:VATB1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VATB1_HUMAN
Pfam	PF00006	http://pfam.xfam.org/family/PF00006
Pfam	PF02874	http://pfam.xfam.org/family/PF02874
PharmGKB	PA25154	http://www.pharmgkb.org/do/serve?objId=PA25154&objCls=Gene
Phobius	swissprot:VATB1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VATB1_HUMAN
PhylomeDB	P15313	http://phylomedb.org/?seqid=P15313
ProteinModelPortal	P15313	http://www.proteinmodelportal.org/query/uniprot/P15313
PubMed	12414817	http://www.ncbi.nlm.nih.gov/pubmed/12414817
PubMed	12444018	http://www.ncbi.nlm.nih.gov/pubmed/12444018
PubMed	12579397	http://www.ncbi.nlm.nih.gov/pubmed/12579397
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	2527371	http://www.ncbi.nlm.nih.gov/pubmed/2527371
PubMed	27535533	http://www.ncbi.nlm.nih.gov/pubmed/27535533
PubMed	9916796	http://www.ncbi.nlm.nih.gov/pubmed/9916796
Reactome	R-HSA-1222556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1222556
Reactome	R-HSA-77387	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-77387
Reactome	R-HSA-917977	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917977
Reactome	R-HSA-983712	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983712
RefSeq	NP_001683	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001683
SMR	P15313	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P15313
STRING	9606.ENSP00000234396	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000234396&targetmode=cogs
STRING	COG1156	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1156&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TCDB	3.A.2.2	http://www.tcdb.org/search/result.php?tc=3.A.2.2
TIGRFAMs	TIGR01040	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01040
UCSC	uc002shj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002shj&org=rat
UniGene	Hs.64173	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.64173
UniProtKB	VATB1_HUMAN	http://www.uniprot.org/uniprot/VATB1_HUMAN
UniProtKB-AC	P15313	http://www.uniprot.org/uniprot/P15313
charge	swissprot:VATB1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VATB1_HUMAN
eggNOG	COG1156	http://eggnogapi.embl.de/nog_data/html/tree/COG1156
eggNOG	KOG1351	http://eggnogapi.embl.de/nog_data/html/tree/KOG1351
epestfind	swissprot:VATB1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VATB1_HUMAN
garnier	swissprot:VATB1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VATB1_HUMAN
helixturnhelix	swissprot:VATB1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VATB1_HUMAN
hmoment	swissprot:VATB1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VATB1_HUMAN
iep	swissprot:VATB1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VATB1_HUMAN
inforesidue	swissprot:VATB1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VATB1_HUMAN
neXtProt	NX_P15313	http://www.nextprot.org/db/entry/NX_P15313
octanol	swissprot:VATB1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VATB1_HUMAN
pepcoil	swissprot:VATB1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VATB1_HUMAN
pepdigest	swissprot:VATB1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VATB1_HUMAN
pepinfo	swissprot:VATB1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VATB1_HUMAN
pepnet	swissprot:VATB1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VATB1_HUMAN
pepstats	swissprot:VATB1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VATB1_HUMAN
pepwheel	swissprot:VATB1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VATB1_HUMAN
pepwindow	swissprot:VATB1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VATB1_HUMAN
sigcleave	swissprot:VATB1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VATB1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TRPC3_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q13507-1; Sequence=Displayed; Name=2; IsoId=Q13507-2; Sequence=VSP_042446; Name=3; IsoId=Q13507-3; Sequence=VSP_042445; 
# AltName	TRPC3_HUMAN	Transient receptor protein 3
# BioGrid	113073	8
# CCDS	CCDS3725	-. [Q13507-3]
# CCDS	CCDS47130	-. [Q13507-2]
# ChiTaRS	TRPC3	human
# DISEASE	TRPC3_HUMAN	Spinocerebellar ataxia 41 (SCA41) [MIM 616410]  A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. {ECO 0000269|PubMed 25477146}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000264811	ENSP00000264811; ENSG00000138741. [Q13507-3]
# Ensembl	ENST00000379645	ENSP00000368966; ENSG00000138741. [Q13507-2]
# ExpressionAtlas	Q13507	baseline and differential
# FUNCTION	TRPC3_HUMAN	Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5- triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion. {ECO 0000269|PubMed 20095964, ECO 0000269|PubMed 8646775, ECO 0000269|PubMed 9417057, ECO 0000269|PubMed 9930701}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:MGI.
# GO_function	GO:0005262	calcium channel activity; TAS:Reactome.
# GO_function	GO:0015279	store-operated calcium channel activity; TAS:ProtInc.
# GO_function	GO:0070679	inositol 1,4,5 trisphosphate binding; IDA:BHF-UCL.
# GO_process	GO:0006816	calcium ion transport; TAS:ProtInc.
# GO_process	GO:0006828	manganese ion transport; IBA:GO_Central.
# GO_process	GO:0007338	single fertilization; IBA:GO_Central.
# GO_process	GO:0007602	phototransduction; TAS:ProtInc.
# GO_process	GO:0010524	positive regulation of calcium ion transport into cytosol; IDA:UniProtKB.
# GO_process	GO:0030168	platelet activation; TAS:Reactome.
# GO_process	GO:0033198	response to ATP; IDA:UniProtKB.
# GO_process	GO:0051592	response to calcium ion; IDA:UniProtKB.
# GO_process	GO:0070588	calcium ion transmembrane transport; IDA:UniProtKB.
# GO_process	GO:1903244	positive regulation of cardiac muscle hypertrophy in response to stress; IDA:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.25.40.20	-; 1.
# Genevisible	Q13507	HS
# HGNC	HGNC:12335	TRPC3
# INTERACTION	TRPC3_HUMAN	Q14573 ITPR3; NbExp=5; IntAct=EBI-520807, EBI-351055; P20591 MX1; NbExp=2; IntAct=EBI-520807, EBI-929476; P10686 Plcg1 (xeno); NbExp=2; IntAct=EBI-520807, EBI-520788; 
# IntAct	Q13507	3
# InterPro	IPR002110	Ankyrin_rpt
# InterPro	IPR002153	TRPC_channel
# InterPro	IPR004729	TRP_channel
# InterPro	IPR005459	TRPC3_channel
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR013555	TRP_dom
# InterPro	IPR020683	Ankyrin_rpt-contain_dom
# KEGG_Brite	ko04040	Ion channels
# MIM	602345	gene
# MIM	616410	phenotype
# Organism	TRPC3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10117	PTHR10117; 2
# PANTHER	PTHR10117:SF8	PTHR10117:SF8; 2
# PRINTS	PR01097	TRNSRECEPTRP
# PRINTS	PR01644	TRPCHANNEL3
# PROSITE	PS50297	ANK_REP_REGION
# Pfam	PF00520	Ion_trans
# Pfam	PF08344	TRP_2
# Pfam	PF12796	Ank_2
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-114508	Effects of PIP2 hydrolysis
# Reactome	R-HSA-139853	Elevation of cytosolic Ca2+ levels
# Reactome	R-HSA-3295583	TRP channels
# Reactome	R-HSA-418890	Role of second messengers in netrin-1 signaling
# RecName	TRPC3_HUMAN	Short transient receptor potential channel 3
# RefSeq	NP_001124170	NM_001130698.1. [Q13507-2]
# RefSeq	NP_003296	NM_003305.2. [Q13507-3]
# SIMILARITY	Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC3 sub-subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 4 ANK repeats. {ECO	0000305}.
# SMART	SM00248	ANK; 3
# SUBCELLULAR LOCATION	TRPC3_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	TRPC3_HUMAN	Interacts with TRPC1, ITPR1, ITPR3, MX1 and RNF24. Interacts with JPH2; the interaction is involved in maintaining Ca(2+) homeostasis in skeletal muscle and is mediated by JPH2 'Ser-165' phosphorylation. {ECO 0000269|PubMed 10611319, ECO 0000269|PubMed 15757897, ECO 0000269|PubMed 17850865, ECO 0000269|PubMed 20095964, ECO 0000269|PubMed 9853757}. 
# SUPFAM	SSF48403	SSF48403
# TCDB	1.A.4.1	the transient receptor potential ca(2+) channel (trp-cc) family
# TIGRFAMs	TIGR00870	trp
# TISSUE SPECIFICITY	TRPC3_HUMAN	Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis. 
# UCSC	uc003ief	human. [Q13507-1]
# eggNOG	ENOG410XQ0Y	LUCA
# eggNOG	KOG3609	Eukaryota
BLAST	swissprot:TRPC3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TRPC3_HUMAN
BioCyc	ZFISH:ENSG00000138741-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000138741-MONOMER
COXPRESdb	7222	http://coxpresdb.jp/data/gene/7222.shtml
CleanEx	HS_TRPC3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TRPC3
DIP	DIP-34311N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-34311N
DOI	10.1002/mds.26096	http://dx.doi.org/10.1002/mds.26096
DOI	10.1016/S0092-8674(00)80302-5	http://dx.doi.org/10.1016/S0092-8674(00)80302-5
DOI	10.1016/S0092-8674(00)81233-7	http://dx.doi.org/10.1016/S0092-8674(00)81233-7
DOI	10.1016/j.ceca.2007.07.009	http://dx.doi.org/10.1016/j.ceca.2007.07.009
DOI	10.1016/j.jmb.2006.12.043	http://dx.doi.org/10.1016/j.jmb.2006.12.043
DOI	10.1038/16711	http://dx.doi.org/10.1038/16711
DOI	10.1038/24890	http://dx.doi.org/10.1038/24890
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1042/BJ20091225	http://dx.doi.org/10.1042/BJ20091225
DOI	10.1073/pnas.0409908102	http://dx.doi.org/10.1073/pnas.0409908102
DOI	10.1073/pnas.92.21.9652	http://dx.doi.org/10.1073/pnas.92.21.9652
DOI	10.1073/pnas.96.26.14955	http://dx.doi.org/10.1073/pnas.96.26.14955
DOI	10.1074/jbc.273.1.133	http://dx.doi.org/10.1074/jbc.273.1.133
DOI	10.1074/jbc.273.15.8675	http://dx.doi.org/10.1074/jbc.273.15.8675
DOI	10.1074/jbc.M500391200	http://dx.doi.org/10.1074/jbc.M500391200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB255424	http://www.ebi.ac.uk/ena/data/view/AB255424
EMBL	AC079341	http://www.ebi.ac.uk/ena/data/view/AC079341
EMBL	AC108930	http://www.ebi.ac.uk/ena/data/view/AC108930
EMBL	AY865574	http://www.ebi.ac.uk/ena/data/view/AY865574
EMBL	BC093682	http://www.ebi.ac.uk/ena/data/view/BC093682
EMBL	BC093684	http://www.ebi.ac.uk/ena/data/view/BC093684
EMBL	U47050	http://www.ebi.ac.uk/ena/data/view/U47050
EMBL	X89068	http://www.ebi.ac.uk/ena/data/view/X89068
EMBL	Y13758	http://www.ebi.ac.uk/ena/data/view/Y13758
Ensembl	ENST00000264811	http://www.ensembl.org/id/ENST00000264811
Ensembl	ENST00000379645	http://www.ensembl.org/id/ENST00000379645
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0015279	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015279
GO_function	GO:0070679	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070679
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0006828	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006828
GO_process	GO:0007338	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007338
GO_process	GO:0007602	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007602
GO_process	GO:0010524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010524
GO_process	GO:0030168	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030168
GO_process	GO:0033198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033198
GO_process	GO:0051592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051592
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:1903244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903244
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.25.40.20	http://www.cathdb.info/version/latest/superfamily/1.25.40.20
GeneCards	TRPC3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TRPC3
GeneID	7222	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7222
GeneTree	ENSGT00760000119180	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119180
HGNC	HGNC:12335	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:12335
HOGENOM	HOG000020590	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000020590&db=HOGENOM6
HOVERGEN	HBG068337	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG068337&db=HOVERGEN
HPA	HPA037969	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA037969
InParanoid	Q13507	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q13507
IntAct	Q13507	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q13507*
InterPro	IPR002110	http://www.ebi.ac.uk/interpro/entry/IPR002110
InterPro	IPR002153	http://www.ebi.ac.uk/interpro/entry/IPR002153
InterPro	IPR004729	http://www.ebi.ac.uk/interpro/entry/IPR004729
InterPro	IPR005459	http://www.ebi.ac.uk/interpro/entry/IPR005459
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR013555	http://www.ebi.ac.uk/interpro/entry/IPR013555
InterPro	IPR020683	http://www.ebi.ac.uk/interpro/entry/IPR020683
Jabion	7222	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7222
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:7222	http://www.genome.jp/dbget-bin/www_bget?hsa:7222
KEGG_Orthology	KO:K04966	http://www.genome.jp/dbget-bin/www_bget?KO:K04966
MIM	602345	http://www.ncbi.nlm.nih.gov/omim/602345
MIM	616410	http://www.ncbi.nlm.nih.gov/omim/616410
OMA	CMEKQRH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CMEKQRH
OrthoDB	EOG091G01FB	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01FB
PANTHER	PTHR10117	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10117
PANTHER	PTHR10117:SF8	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10117:SF8
PRINTS	PR01097	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01097
PRINTS	PR01644	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01644
PROSITE	PS50297	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50297
PSORT	swissprot:TRPC3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TRPC3_HUMAN
PSORT-B	swissprot:TRPC3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TRPC3_HUMAN
PSORT2	swissprot:TRPC3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TRPC3_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF08344	http://pfam.xfam.org/family/PF08344
Pfam	PF12796	http://pfam.xfam.org/family/PF12796
PharmGKB	PA37008	http://www.pharmgkb.org/do/serve?objId=PA37008&objCls=Gene
Phobius	swissprot:TRPC3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TRPC3_HUMAN
ProteinModelPortal	Q13507	http://www.proteinmodelportal.org/query/uniprot/Q13507
PubMed	10611319	http://www.ncbi.nlm.nih.gov/pubmed/10611319
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15728370	http://www.ncbi.nlm.nih.gov/pubmed/15728370
PubMed	15757897	http://www.ncbi.nlm.nih.gov/pubmed/15757897
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	17258231	http://www.ncbi.nlm.nih.gov/pubmed/17258231
PubMed	17850865	http://www.ncbi.nlm.nih.gov/pubmed/17850865
PubMed	20095964	http://www.ncbi.nlm.nih.gov/pubmed/20095964
PubMed	25477146	http://www.ncbi.nlm.nih.gov/pubmed/25477146
PubMed	7568191	http://www.ncbi.nlm.nih.gov/pubmed/7568191
PubMed	8646775	http://www.ncbi.nlm.nih.gov/pubmed/8646775
PubMed	9215637	http://www.ncbi.nlm.nih.gov/pubmed/9215637
PubMed	9417057	http://www.ncbi.nlm.nih.gov/pubmed/9417057
PubMed	9535843	http://www.ncbi.nlm.nih.gov/pubmed/9535843
PubMed	9853757	http://www.ncbi.nlm.nih.gov/pubmed/9853757
PubMed	9930701	http://www.ncbi.nlm.nih.gov/pubmed/9930701
Reactome	R-HSA-114508	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-114508
Reactome	R-HSA-139853	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-139853
Reactome	R-HSA-3295583	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3295583
Reactome	R-HSA-418890	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418890
RefSeq	NP_001124170	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001124170
RefSeq	NP_003296	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003296
SMART	SM00248	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00248
STRING	9606.ENSP00000368966	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000368966&targetmode=cogs
SUPFAM	SSF48403	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48403
TCDB	1.A.4.1	http://www.tcdb.org/search/result.php?tc=1.A.4.1
TIGRFAMs	TIGR00870	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00870
UCSC	uc003ief	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ief&org=rat
UniGene	Hs.150981	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.150981
UniProtKB	TRPC3_HUMAN	http://www.uniprot.org/uniprot/TRPC3_HUMAN
UniProtKB-AC	Q13507	http://www.uniprot.org/uniprot/Q13507
charge	swissprot:TRPC3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TRPC3_HUMAN
eggNOG	ENOG410XQ0Y	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ0Y
eggNOG	KOG3609	http://eggnogapi.embl.de/nog_data/html/tree/KOG3609
epestfind	swissprot:TRPC3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TRPC3_HUMAN
garnier	swissprot:TRPC3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TRPC3_HUMAN
helixturnhelix	swissprot:TRPC3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRPC3_HUMAN
hmoment	swissprot:TRPC3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TRPC3_HUMAN
iep	swissprot:TRPC3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TRPC3_HUMAN
inforesidue	swissprot:TRPC3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TRPC3_HUMAN
neXtProt	NX_Q13507	http://www.nextprot.org/db/entry/NX_Q13507
octanol	swissprot:TRPC3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TRPC3_HUMAN
pepcoil	swissprot:TRPC3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TRPC3_HUMAN
pepdigest	swissprot:TRPC3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TRPC3_HUMAN
pepinfo	swissprot:TRPC3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TRPC3_HUMAN
pepnet	swissprot:TRPC3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TRPC3_HUMAN
pepstats	swissprot:TRPC3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TRPC3_HUMAN
pepwheel	swissprot:TRPC3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TRPC3_HUMAN
pepwindow	swissprot:TRPC3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TRPC3_HUMAN
sigcleave	swissprot:TRPC3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TRPC3_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNJ4_HUMAN	HIRK2
# AltName	KCNJ4_HUMAN	HRK1
# AltName	KCNJ4_HUMAN	Hippocampal inward rectifier
# AltName	KCNJ4_HUMAN	Inward rectifier K(+) channel Kir2.3
# AltName	KCNJ4_HUMAN	Potassium channel, inwardly rectifying subfamily J member 4
# BioGrid	109963	10
# DOMAIN	KCNJ4_HUMAN	The Val/Gly/Ala/Pro stretch may have a functional role in the conductance or permeation properties. 
# Ensembl	ENST00000303592	ENSP00000306497; ENSG00000168135
# ExpressionAtlas	P48050	baseline and differential
# FUNCTION	KCNJ4_HUMAN	Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008076	voltage-gated potassium channel complex; TAS:ProtInc.
# GO_component	GO:0016323	basolateral plasma membrane; IDA:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030659	cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0005242	inward rectifier potassium channel activity; TAS:ProtInc.
# GO_function	GO:0015467	G-protein activated inward rectifier potassium channel activity; TAS:Reactome.
# GO_function	GO:0030165	PDZ domain binding; IPI:UniProtKB.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0010107	potassium ion import; IBA:GO_Central.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.40.1400	-; 1.
# Genevisible	P48050	HS
# HGNC	HGNC:6265	KCNJ4
# IntAct	P48050	3
# InterPro	IPR003273	K_chnl_inward-rec_Kir2.3
# InterPro	IPR013518	K_chnl_inward-rec_Kir_cyto
# InterPro	IPR014756	Ig_E-set
# InterPro	IPR016449	K_chnl_inward-rec_Kir
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04725	Cholinergic synapse
# MIM	600504	gene
# Organism	KCNJ4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11767	PTHR11767; 3
# PDB	3GJ9	X-ray; 2.80 A; C/D=436-445
# PIR	A54852	A54852
# PIR	I38521	I38521
# PIRSF	PIRSF005465	GIRK_kir
# PRINTS	PR01320	KIRCHANNEL
# PRINTS	PR01326	KIR23CHANNEL
# Pfam	PF01007	IRK
# Proteomes	UP000005640	Chromosome 22
# Reactome	R-HSA-1296041	Activation of G protein gated Potassium channels
# Reactome	R-HSA-1296053	Classical Kir channels
# Reactome	R-HSA-5576886	Phase 4 - resting membrane potential
# Reactome	R-HSA-997272	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
# RecName	KCNJ4_HUMAN	Inward rectifier potassium channel 4
# RefSeq	NP_004972	NM_004981.1
# RefSeq	NP_690607	NM_152868.2
# SIMILARITY	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ4 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCNJ4_HUMAN	Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Cytoplasmic vesicle membrane {ECO 0000250}. Note=TAX1BP3 binding promotes dissociation of KCNJ4 from LIN7 famaly members and KCNJ4 internalization. {ECO 0000250}. 
# SUBUNIT	KCNJ4_HUMAN	Homomultimeric and heteromultimeric association with KCNJ2 and KCNJ12. Association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role in its localization and trafficking (By similarity). Interacts with TAX1BP3. TAX1BP3 competes with LIN7 family members for KCNJ4 binding. {ECO 0000250, ECO 0000269|PubMed 12032359, ECO 0000269|PubMed 19635485}. 
# SUPFAM	SSF81296	SSF81296
# TISSUE SPECIFICITY	KCNJ4_HUMAN	Heart, skeletal muscle, and several different brain regions including the hippocampus. 
# UCSC	uc003avt	human
# eggNOG	ENOG410XQ62	LUCA
# eggNOG	KOG3827	Eukaryota
BLAST	swissprot:KCNJ4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNJ4_HUMAN
BioCyc	ZFISH:ENSG00000168135-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000168135-MONOMER
COXPRESdb	3761	http://coxpresdb.jp/data/gene/3761.shtml
CleanEx	HS_KCNJ4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNJ4
DOI	10.1016/0014-5793(94)00612-1	http://dx.doi.org/10.1016/0014-5793(94)00612-1
DOI	10.1016/0896-6273(95)90103-5	http://dx.doi.org/10.1016/0896-6273(95)90103-5
DOI	10.1016/j.jmb.2009.07.060	http://dx.doi.org/10.1016/j.jmb.2009.07.060
DOI	10.1038/990031	http://dx.doi.org/10.1038/990031
DOI	10.1073/pnas.102609499	http://dx.doi.org/10.1073/pnas.102609499
DOI	10.1073/pnas.91.13.6240	http://dx.doi.org/10.1073/pnas.91.13.6240
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/gb-2004-5-10-r84	http://dx.doi.org/10.1186/gb-2004-5-10-r84
EMBL	BC113506	http://www.ebi.ac.uk/ena/data/view/BC113506
EMBL	BC113508	http://www.ebi.ac.uk/ena/data/view/BC113508
EMBL	CR456507	http://www.ebi.ac.uk/ena/data/view/CR456507
EMBL	S72503	http://www.ebi.ac.uk/ena/data/view/S72503
EMBL	U07364	http://www.ebi.ac.uk/ena/data/view/U07364
EMBL	U24056	http://www.ebi.ac.uk/ena/data/view/U24056
EMBL	Z97056	http://www.ebi.ac.uk/ena/data/view/Z97056
Ensembl	ENST00000303592	http://www.ensembl.org/id/ENST00000303592
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030659
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0005242	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005242
GO_function	GO:0015467	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015467
GO_function	GO:0030165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030165
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0010107	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010107
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.40.1400	http://www.cathdb.info/version/latest/superfamily/2.60.40.1400
GeneCards	KCNJ4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNJ4
GeneID	3761	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3761
GeneTree	ENSGT00760000118842	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118842
H-InvDB	HIX0175381	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0175381
HGNC	HGNC:6265	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6265
HOGENOM	HOG000237325	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237325&db=HOGENOM6
HOVERGEN	HBG006178	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006178&db=HOVERGEN
InParanoid	P48050	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P48050
IntAct	P48050	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P48050*
InterPro	IPR003273	http://www.ebi.ac.uk/interpro/entry/IPR003273
InterPro	IPR013518	http://www.ebi.ac.uk/interpro/entry/IPR013518
InterPro	IPR014756	http://www.ebi.ac.uk/interpro/entry/IPR014756
InterPro	IPR016449	http://www.ebi.ac.uk/interpro/entry/IPR016449
Jabion	3761	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3761
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3761	http://www.genome.jp/dbget-bin/www_bget?hsa:3761
KEGG_Orthology	KO:K04998	http://www.genome.jp/dbget-bin/www_bget?KO:K04998
KEGG_Pathway	ko04725	http://www.genome.jp/kegg-bin/show_pathway?ko04725
MIM	600504	http://www.ncbi.nlm.nih.gov/omim/600504
MINT	MINT-159020	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-159020
OMA	HAPRRKH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HAPRRKH
OrthoDB	EOG091G08HC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08HC
PANTHER	PTHR11767	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11767
PDB	3GJ9	http://www.ebi.ac.uk/pdbe-srv/view/entry/3GJ9
PDBsum	3GJ9	http://www.ebi.ac.uk/pdbsum/3GJ9
PRINTS	PR01320	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01320
PRINTS	PR01326	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01326
PSORT	swissprot:KCNJ4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNJ4_HUMAN
PSORT-B	swissprot:KCNJ4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNJ4_HUMAN
PSORT2	swissprot:KCNJ4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNJ4_HUMAN
Pfam	PF01007	http://pfam.xfam.org/family/PF01007
PharmGKB	PA30048	http://www.pharmgkb.org/do/serve?objId=PA30048&objCls=Gene
Phobius	swissprot:KCNJ4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNJ4_HUMAN
PhylomeDB	P48050	http://phylomedb.org/?seqid=P48050
ProteinModelPortal	P48050	http://www.proteinmodelportal.org/query/uniprot/P48050
PubMed	10591208	http://www.ncbi.nlm.nih.gov/pubmed/10591208
PubMed	12032359	http://www.ncbi.nlm.nih.gov/pubmed/12032359
PubMed	15461802	http://www.ncbi.nlm.nih.gov/pubmed/15461802
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19635485	http://www.ncbi.nlm.nih.gov/pubmed/19635485
PubMed	7576658	http://www.ncbi.nlm.nih.gov/pubmed/7576658
PubMed	8016146	http://www.ncbi.nlm.nih.gov/pubmed/8016146
PubMed	8034048	http://www.ncbi.nlm.nih.gov/pubmed/8034048
PubMed	8051145	http://www.ncbi.nlm.nih.gov/pubmed/8051145
Reactome	R-HSA-1296041	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296041
Reactome	R-HSA-1296053	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296053
Reactome	R-HSA-5576886	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576886
Reactome	R-HSA-997272	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-997272
RefSeq	NP_004972	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004972
RefSeq	NP_690607	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_690607
SMR	P48050	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P48050
STRING	9606.ENSP00000306497	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000306497&targetmode=cogs
SUPFAM	SSF81296	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81296
UCSC	uc003avt	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003avt&org=rat
UniGene	Hs.32505	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.32505
UniProtKB	KCNJ4_HUMAN	http://www.uniprot.org/uniprot/KCNJ4_HUMAN
UniProtKB-AC	P48050	http://www.uniprot.org/uniprot/P48050
charge	swissprot:KCNJ4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNJ4_HUMAN
eggNOG	ENOG410XQ62	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ62
eggNOG	KOG3827	http://eggnogapi.embl.de/nog_data/html/tree/KOG3827
epestfind	swissprot:KCNJ4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNJ4_HUMAN
garnier	swissprot:KCNJ4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNJ4_HUMAN
helixturnhelix	swissprot:KCNJ4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNJ4_HUMAN
hmoment	swissprot:KCNJ4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNJ4_HUMAN
iep	swissprot:KCNJ4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNJ4_HUMAN
inforesidue	swissprot:KCNJ4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNJ4_HUMAN
neXtProt	NX_P48050	http://www.nextprot.org/db/entry/NX_P48050
octanol	swissprot:KCNJ4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNJ4_HUMAN
pepcoil	swissprot:KCNJ4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNJ4_HUMAN
pepdigest	swissprot:KCNJ4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNJ4_HUMAN
pepinfo	swissprot:KCNJ4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNJ4_HUMAN
pepnet	swissprot:KCNJ4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNJ4_HUMAN
pepstats	swissprot:KCNJ4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNJ4_HUMAN
pepwheel	swissprot:KCNJ4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNJ4_HUMAN
pepwindow	swissprot:KCNJ4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNJ4_HUMAN
sigcleave	swissprot:KCNJ4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNJ4_HUMAN
## Database	ID	URL or Descriptions
# AltName	ATP6_HUMAN	F-ATPase protein 6
# DISEASE	ATP6_HUMAN	Leber hereditary optic neuropathy (LHON) [MIM 535000]  A maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes. {ECO 0000269|PubMed 7726182}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ATP6_HUMAN	Leigh syndrome (LS) [MIM 256000]  An early-onset progressive neurodegenerative disorder characterized by the presence of focal, bilateral lesions in one or more areas of the central nervous system including the brainstem, thalamus, basal ganglia, cerebellum and spinal cord. Clinical features depend on which areas of the central nervous system are involved and include subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, and dysphagia. {ECO 0000269|PubMed 17352390, ECO 0000269|PubMed 8395787, ECO 0000269|PubMed 9270604, ECO 0000269|PubMed 9501263, ECO 0000269|PubMed 9556461}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ATP6_HUMAN	Mitochondrial complex V deficiency, mitochondrial 1 (MC5DM1) [MIM 516060]  A mitochondrial disorder with heterogeneous clinical manifestations including neuropathy, ataxia, hypertrophic cardiomyopathy. Hypertrophic cardiomyopathy can present with negligible to extreme hypertrophy, minimal to extensive fibrosis and myocyte disarray, absent to severe left ventricular outflow tract obstruction, and distinct septal contours/morphologies with extremely varying clinical course. {ECO 0000269|PubMed 16049925, ECO 0000269|PubMed 18055910}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ATP6_HUMAN	Mitochondrial infantile bilateral striatal necrosis (MIBSN) [MIM 500003]  Bilateral striatal necrosis is a neurological disorder resembling Leigh syndrome. {ECO 0000269|PubMed 7668837}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ATP6_HUMAN	Myopathy, lactic acidosis, and sideroblastic anemia 3 (MLASA3) [MIM 500011]  A rare mitochondrial disorder characterized by sideroblastic anemia, muscle weakness, and exercise intolerance associated with persistent lactic acidemia. Additional MLASA3 features are failure to thrive, hearing loss, epilepsy, stroke- like episodes, and severe developmental delay. {ECO 0000269|PubMed 25037980}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ATP6_HUMAN	Neuropathy, ataxia, and retinitis pigmentosa (NARP) [MIM 551500]  A syndrome characterized by variable combination of developmental delay, psychomotor retardation, hearing loss, optic atrophy and retinitis pigmentosa, dementia, seizures, ataxia, proximal neurogenic muscle weakness, and sensory neuropathy. {ECO 0000269|PubMed 2137962}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000361899	ENSP00000354632; ENSG00000198899
# ExpressionAtlas	P00846	baseline and differential
# FUNCTION	ATP6_HUMAN	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane. 
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0005753	mitochondrial proton-transporting ATP synthase complex; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o); IEA:UniProtKB-KW.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0015078	hydrogen ion transmembrane transporter activity; IEA:InterPro.
# GO_function	GO:0022857	transmembrane transporter activity; IC:UniProtKB.
# GO_process	GO:0006754	ATP biosynthetic process; TAS:Reactome.
# GO_process	GO:0007568	aging; IEA:Ensembl.
# GO_process	GO:0042776	mitochondrial ATP synthesis coupled proton transport; IC:UniProtKB.
# GO_process	GO:0055093	response to hyperoxia; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007568	aging
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.220	-; 1.
# Genevisible	P00846	HS
# HGNC	HGNC:7414	MT-ATP6
# IntAct	P00846	14
# InterPro	IPR000568	ATP_synth_F0_asu
# InterPro	IPR023011	ATP_synth_F0_asu_AS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Disease	H00068	[Neurodegenerative disease] Leber hereditary optic atrophy (LHON)
# KEGG_Disease	H01177	[Nervous system disease] Infantile bilateral striatal necrosis (IBSN)
# KEGG_Disease	H01355	[Inherited metabolic disease; Mitochondrial disease] Kearns-Sayre Syndrome
# KEGG_Disease	H01363	[Inherited metabolic disease; Neurodegenerative disease; Mitochondrial disease] Neuropathy ataxia and retinis pigmentosa
# KEGG_Disease	H01369	[Inherited metabolic disease; Mitochondrial disease] Mitochondrial infantile bilateral striatal necrosis (MIBSN)
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	256000	phenotype
# MIM	500003	phenotype
# MIM	500011	phenotype
# MIM	516060	gene+phenotype
# MIM	535000	phenotype
# MIM	551500	phenotype
# Organism	ATP6_HUMAN	Homo sapiens (Human)
# Orphanet	104	Leber hereditary optic neuropathy
# Orphanet	155	Familial isolated hypertrophic cardiomyopathy
# Orphanet	225154	Familial infantile bilateral striatal necrosis
# Orphanet	255210	Maternally-inherited Leigh syndrome
# Orphanet	320360	Maternally-inherited spastic paraplegia
# Orphanet	397750	Periodic paralysis with later-onset distal motor neuropathy
# Orphanet	644	NARP syndrome
# PANTHER	PTHR11410	PTHR11410
# PIR	A01049	PWHU6
# PRINTS	PR00123	ATPASEA
# PROSITE	PS00449	ATPASE_A
# Pfam	PF00119	ATP-synt_A
# Proteomes	UP000005640	Mitochondrion
# Reactome	R-HSA-163210	Formation of ATP by chemiosmotic coupling
# RecName	ATP6_HUMAN	ATP synthase subunit a
# RefSeq	YP_003024031	NC_012920.1
# SIMILARITY	Belongs to the ATPase A chain family. {ECO	0000305}.
# SUBCELLULAR LOCATION	ATP6_HUMAN	Mitochondrion inner membrane; Multi-pass membrane protein. 
# SUBUNIT	F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits	 a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity). {ECO:0000250}. 
# SUPFAM	SSF81336	SSF81336
# TIGRFAMs	TIGR01131	ATP_synt_6_or_A
# eggNOG	COG0356	LUCA
# eggNOG	KOG4665	Eukaryota
BLAST	swissprot:ATP6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ATP6_HUMAN
COG	COG0356	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0356
COXPRESdb	4508	http://coxpresdb.jp/data/gene/4508.shtml
DOI	10.1002/ajmg.a.31637	http://dx.doi.org/10.1002/ajmg.a.31637
DOI	10.1002/ana.20555	http://dx.doi.org/10.1002/ana.20555
DOI	10.1002/ana.410340319	http://dx.doi.org/10.1002/ana.410340319
DOI	10.1002/ana.410380321	http://dx.doi.org/10.1002/ana.410380321
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1007/BF00206061	http://dx.doi.org/10.1007/BF00206061
DOI	10.1007/s00414-004-0427-6	http://dx.doi.org/10.1007/s00414-004-0427-6
DOI	10.1016/j.ymgme.2014.06.004	http://dx.doi.org/10.1016/j.ymgme.2014.06.004
DOI	10.1023/A:1005397227996	http://dx.doi.org/10.1023/A:1005397227996
DOI	10.1038/290457a0	http://dx.doi.org/10.1038/290457a0
DOI	10.1038/35047064	http://dx.doi.org/10.1038/35047064
DOI	10.1046/j.1529-8817.2003.00127.x	http://dx.doi.org/10.1046/j.1529-8817.2003.00127.x
DOI	10.1073/pnas.0136972100	http://dx.doi.org/10.1073/pnas.0136972100
DOI	10.1073/pnas.92.2.532	http://dx.doi.org/10.1073/pnas.92.2.532
DOI	10.1086/301751	http://dx.doi.org/10.1086/301751
DOI	10.1086/341358	http://dx.doi.org/10.1086/341358
DOI	10.1086/377718	http://dx.doi.org/10.1086/377718
DOI	10.1086/425590	http://dx.doi.org/10.1086/425590
DOI	10.1086/425871	http://dx.doi.org/10.1086/425871
DOI	10.1093/molbev/msg230	http://dx.doi.org/10.1093/molbev/msg230
DOI	10.1093/nar/26.4.967	http://dx.doi.org/10.1093/nar/26.4.967
DOI	10.1101/gr.686603	http://dx.doi.org/10.1101/gr.686603
DOI	10.1126/science.3201231	http://dx.doi.org/10.1126/science.3201231
DOI	10.1136/jmg.2007.052902	http://dx.doi.org/10.1136/jmg.2007.052902
DOI	10.1186/1471-2156-2-13	http://dx.doi.org/10.1186/1471-2156-2-13
DOI	10.1186/1471-2156-4-15	http://dx.doi.org/10.1186/1471-2156-4-15
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1212/WNL.49.2.595	http://dx.doi.org/10.1212/WNL.49.2.595
EMBL	AF346971	http://www.ebi.ac.uk/ena/data/view/AF346971
EMBL	AF347011	http://www.ebi.ac.uk/ena/data/view/AF347011
EMBL	AF381997	http://www.ebi.ac.uk/ena/data/view/AF381997
EMBL	AF382010	http://www.ebi.ac.uk/ena/data/view/AF382010
EMBL	AF465948	http://www.ebi.ac.uk/ena/data/view/AF465948
EMBL	AF465949	http://www.ebi.ac.uk/ena/data/view/AF465949
EMBL	AF465950	http://www.ebi.ac.uk/ena/data/view/AF465950
EMBL	AF465956	http://www.ebi.ac.uk/ena/data/view/AF465956
EMBL	AF465957	http://www.ebi.ac.uk/ena/data/view/AF465957
EMBL	AF465962	http://www.ebi.ac.uk/ena/data/view/AF465962
EMBL	AF465972	http://www.ebi.ac.uk/ena/data/view/AF465972
EMBL	AF465974	http://www.ebi.ac.uk/ena/data/view/AF465974
EMBL	AF465975	http://www.ebi.ac.uk/ena/data/view/AF465975
EMBL	AF465976	http://www.ebi.ac.uk/ena/data/view/AF465976
EMBL	AY195749	http://www.ebi.ac.uk/ena/data/view/AY195749
EMBL	AY195764	http://www.ebi.ac.uk/ena/data/view/AY195764
EMBL	AY195773	http://www.ebi.ac.uk/ena/data/view/AY195773
EMBL	AY195786	http://www.ebi.ac.uk/ena/data/view/AY195786
EMBL	AY255144	http://www.ebi.ac.uk/ena/data/view/AY255144
EMBL	AY255147	http://www.ebi.ac.uk/ena/data/view/AY255147
EMBL	AY255180	http://www.ebi.ac.uk/ena/data/view/AY255180
EMBL	AY275529	http://www.ebi.ac.uk/ena/data/view/AY275529
EMBL	AY289076	http://www.ebi.ac.uk/ena/data/view/AY289076
EMBL	AY289100	http://www.ebi.ac.uk/ena/data/view/AY289100
EMBL	AY339407	http://www.ebi.ac.uk/ena/data/view/AY339407
EMBL	AY339408	http://www.ebi.ac.uk/ena/data/view/AY339408
EMBL	AY339510	http://www.ebi.ac.uk/ena/data/view/AY339510
EMBL	AY339511	http://www.ebi.ac.uk/ena/data/view/AY339511
EMBL	AY339512	http://www.ebi.ac.uk/ena/data/view/AY339512
EMBL	AY339513	http://www.ebi.ac.uk/ena/data/view/AY339513
EMBL	AY339530	http://www.ebi.ac.uk/ena/data/view/AY339530
EMBL	AY339531	http://www.ebi.ac.uk/ena/data/view/AY339531
EMBL	AY339532	http://www.ebi.ac.uk/ena/data/view/AY339532
EMBL	AY339533	http://www.ebi.ac.uk/ena/data/view/AY339533
EMBL	AY339534	http://www.ebi.ac.uk/ena/data/view/AY339534
EMBL	AY339535	http://www.ebi.ac.uk/ena/data/view/AY339535
EMBL	AY339536	http://www.ebi.ac.uk/ena/data/view/AY339536
EMBL	AY339537	http://www.ebi.ac.uk/ena/data/view/AY339537
EMBL	AY339538	http://www.ebi.ac.uk/ena/data/view/AY339538
EMBL	AY339539	http://www.ebi.ac.uk/ena/data/view/AY339539
EMBL	AY339540	http://www.ebi.ac.uk/ena/data/view/AY339540
EMBL	AY339541	http://www.ebi.ac.uk/ena/data/view/AY339541
EMBL	AY339543	http://www.ebi.ac.uk/ena/data/view/AY339543
EMBL	AY339581	http://www.ebi.ac.uk/ena/data/view/AY339581
EMBL	AY339582	http://www.ebi.ac.uk/ena/data/view/AY339582
EMBL	AY339584	http://www.ebi.ac.uk/ena/data/view/AY339584
EMBL	AY495147	http://www.ebi.ac.uk/ena/data/view/AY495147
EMBL	AY495199	http://www.ebi.ac.uk/ena/data/view/AY495199
EMBL	AY495231	http://www.ebi.ac.uk/ena/data/view/AY495231
EMBL	AY495232	http://www.ebi.ac.uk/ena/data/view/AY495232
EMBL	AY495233	http://www.ebi.ac.uk/ena/data/view/AY495233
EMBL	AY495234	http://www.ebi.ac.uk/ena/data/view/AY495234
EMBL	AY495235	http://www.ebi.ac.uk/ena/data/view/AY495235
EMBL	AY495236	http://www.ebi.ac.uk/ena/data/view/AY495236
EMBL	AY495237	http://www.ebi.ac.uk/ena/data/view/AY495237
EMBL	AY495238	http://www.ebi.ac.uk/ena/data/view/AY495238
EMBL	AY519488	http://www.ebi.ac.uk/ena/data/view/AY519488
EMBL	AY713988	http://www.ebi.ac.uk/ena/data/view/AY713988
EMBL	AY713999	http://www.ebi.ac.uk/ena/data/view/AY713999
EMBL	AY714004	http://www.ebi.ac.uk/ena/data/view/AY714004
EMBL	AY714013	http://www.ebi.ac.uk/ena/data/view/AY714013
EMBL	AY714014	http://www.ebi.ac.uk/ena/data/view/AY714014
EMBL	AY714028	http://www.ebi.ac.uk/ena/data/view/AY714028
EMBL	AY714031	http://www.ebi.ac.uk/ena/data/view/AY714031
EMBL	AY714035	http://www.ebi.ac.uk/ena/data/view/AY714035
EMBL	AY714045	http://www.ebi.ac.uk/ena/data/view/AY714045
EMBL	AY738945	http://www.ebi.ac.uk/ena/data/view/AY738945
EMBL	AY738967	http://www.ebi.ac.uk/ena/data/view/AY738967
EMBL	D38112	http://www.ebi.ac.uk/ena/data/view/D38112
EMBL	J01415	http://www.ebi.ac.uk/ena/data/view/J01415
EMBL	V00662	http://www.ebi.ac.uk/ena/data/view/V00662
Ensembl	ENST00000361899	http://www.ensembl.org/id/ENST00000361899
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005753	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005753
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0045263	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045263
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0015078	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015078
GO_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GO_process	GO:0006754	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006754
GO_process	GO:0007568	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007568
GO_process	GO:0042776	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042776
GO_process	GO:0055093	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055093
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007568	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007568
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.220	http://www.cathdb.info/version/latest/superfamily/1.20.120.220
GeneCards	MT-ATP6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=MT-ATP6
GeneID	4508	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4508
GeneTree	ENSGT00390000005568	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000005568
HGNC	HGNC:7414	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:7414
HOVERGEN	HBG016693	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG016693&db=HOVERGEN
InParanoid	P00846	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00846
IntAct	P00846	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00846*
InterPro	IPR000568	http://www.ebi.ac.uk/interpro/entry/IPR000568
InterPro	IPR023011	http://www.ebi.ac.uk/interpro/entry/IPR023011
Jabion	4508	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=4508
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Disease	H00068	http://www.genome.jp/dbget-bin/www_bget?H00068
KEGG_Disease	H01177	http://www.genome.jp/dbget-bin/www_bget?H01177
KEGG_Disease	H01355	http://www.genome.jp/dbget-bin/www_bget?H01355
KEGG_Disease	H01363	http://www.genome.jp/dbget-bin/www_bget?H01363
KEGG_Disease	H01369	http://www.genome.jp/dbget-bin/www_bget?H01369
KEGG_Gene	hsa:4508	http://www.genome.jp/dbget-bin/www_bget?hsa:4508
KEGG_Orthology	KO:K02126	http://www.genome.jp/dbget-bin/www_bget?KO:K02126
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	256000	http://www.ncbi.nlm.nih.gov/omim/256000
MIM	500003	http://www.ncbi.nlm.nih.gov/omim/500003
MIM	500011	http://www.ncbi.nlm.nih.gov/omim/500011
MIM	516060	http://www.ncbi.nlm.nih.gov/omim/516060
MIM	535000	http://www.ncbi.nlm.nih.gov/omim/535000
MIM	551500	http://www.ncbi.nlm.nih.gov/omim/551500
OMA	ALIMIET	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ALIMIET
Orphanet	104	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=104
Orphanet	155	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=155
Orphanet	225154	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=225154
Orphanet	255210	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=255210
Orphanet	320360	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=320360
Orphanet	397750	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=397750
Orphanet	644	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=644
OrthoDB	EOG091G12DP	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G12DP
PANTHER	PTHR11410	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11410
PRINTS	PR00123	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00123
PROSITE	PS00449	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00449
PSORT	swissprot:ATP6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ATP6_HUMAN
PSORT-B	swissprot:ATP6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ATP6_HUMAN
PSORT2	swissprot:ATP6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ATP6_HUMAN
Pfam	PF00119	http://pfam.xfam.org/family/PF00119
Phobius	swissprot:ATP6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ATP6_HUMAN
PhylomeDB	P00846	http://phylomedb.org/?seqid=P00846
ProteinModelPortal	P00846	http://www.proteinmodelportal.org/query/uniprot/P00846
PubMed	11130070	http://www.ncbi.nlm.nih.gov/pubmed/11130070
PubMed	11553319	http://www.ncbi.nlm.nih.gov/pubmed/11553319
PubMed	12022039	http://www.ncbi.nlm.nih.gov/pubmed/12022039
PubMed	12509511	http://www.ncbi.nlm.nih.gov/pubmed/12509511
PubMed	12840039	http://www.ncbi.nlm.nih.gov/pubmed/12840039
PubMed	12870132	http://www.ncbi.nlm.nih.gov/pubmed/12870132
PubMed	12949126	http://www.ncbi.nlm.nih.gov/pubmed/12949126
PubMed	14563219	http://www.ncbi.nlm.nih.gov/pubmed/14563219
PubMed	14760490	http://www.ncbi.nlm.nih.gov/pubmed/14760490
PubMed	15382008	http://www.ncbi.nlm.nih.gov/pubmed/15382008
PubMed	15467980	http://www.ncbi.nlm.nih.gov/pubmed/15467980
PubMed	15638829	http://www.ncbi.nlm.nih.gov/pubmed/15638829
PubMed	16049925	http://www.ncbi.nlm.nih.gov/pubmed/16049925
PubMed	17352390	http://www.ncbi.nlm.nih.gov/pubmed/17352390
PubMed	1757091	http://www.ncbi.nlm.nih.gov/pubmed/1757091
PubMed	18055910	http://www.ncbi.nlm.nih.gov/pubmed/18055910
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	2137962	http://www.ncbi.nlm.nih.gov/pubmed/2137962
PubMed	25037980	http://www.ncbi.nlm.nih.gov/pubmed/25037980
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	3201231	http://www.ncbi.nlm.nih.gov/pubmed/3201231
PubMed	7219534	http://www.ncbi.nlm.nih.gov/pubmed/7219534
PubMed	7530363	http://www.ncbi.nlm.nih.gov/pubmed/7530363
PubMed	7668837	http://www.ncbi.nlm.nih.gov/pubmed/7668837
PubMed	7726182	http://www.ncbi.nlm.nih.gov/pubmed/7726182
PubMed	8395787	http://www.ncbi.nlm.nih.gov/pubmed/8395787
PubMed	9270604	http://www.ncbi.nlm.nih.gov/pubmed/9270604
PubMed	9461455	http://www.ncbi.nlm.nih.gov/pubmed/9461455
PubMed	9501263	http://www.ncbi.nlm.nih.gov/pubmed/9501263
PubMed	9556461	http://www.ncbi.nlm.nih.gov/pubmed/9556461
Reactome	R-HSA-163210	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-163210
RefSeq	YP_003024031	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_003024031
STRING	9606.ENSP00000354632	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000354632&targetmode=cogs
STRING	COG0356	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0356&targetmode=cogs
SUPFAM	SSF81336	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81336
TIGRFAMs	TIGR01131	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01131
UniProtKB	ATP6_HUMAN	http://www.uniprot.org/uniprot/ATP6_HUMAN
UniProtKB-AC	P00846	http://www.uniprot.org/uniprot/P00846
charge	swissprot:ATP6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ATP6_HUMAN
eggNOG	COG0356	http://eggnogapi.embl.de/nog_data/html/tree/COG0356
eggNOG	KOG4665	http://eggnogapi.embl.de/nog_data/html/tree/KOG4665
epestfind	swissprot:ATP6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ATP6_HUMAN
garnier	swissprot:ATP6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ATP6_HUMAN
helixturnhelix	swissprot:ATP6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATP6_HUMAN
hmoment	swissprot:ATP6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ATP6_HUMAN
iep	swissprot:ATP6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ATP6_HUMAN
inforesidue	swissprot:ATP6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ATP6_HUMAN
neXtProt	NX_P00846	http://www.nextprot.org/db/entry/NX_P00846
octanol	swissprot:ATP6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ATP6_HUMAN
pepcoil	swissprot:ATP6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ATP6_HUMAN
pepdigest	swissprot:ATP6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ATP6_HUMAN
pepinfo	swissprot:ATP6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ATP6_HUMAN
pepnet	swissprot:ATP6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ATP6_HUMAN
pepstats	swissprot:ATP6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ATP6_HUMAN
pepwheel	swissprot:ATP6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ATP6_HUMAN
pepwindow	swissprot:ATP6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ATP6_HUMAN
sigcleave	swissprot:ATP6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ATP6_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S17A5_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NRA2-1; Sequence=Displayed; Name=2; IsoId=Q9NRA2-2; Sequence=VSP_010482, VSP_010483; 
# AltName	S17A5_HUMAN	H(+)/nitrate cotransporter
# AltName	S17A5_HUMAN	H(+)/sialic acid cotransporter
# AltName	S17A5_HUMAN	Membrane glycoprotein HP59
# AltName	S17A5_HUMAN	Solute carrier family 17 member 5
# AltName	S17A5_HUMAN	Vesicular H(+)/Aspartate-glutamate cotransporter
# BioGrid	117710	3
# CCDS	CCDS4981	-. [Q9NRA2-1]
# CDD	cd06174	MFS
# ChiTaRS	SLC17A5	human
# DISEASE	S17A5_HUMAN	Infantile sialic acid storage disorder (ISSD) [MIM 269920]  Severe form of sialic acid storage disease. Affected newborns exhibit visceromegaly, coarse features and failure to thrive immediately after birth. These patients have a shortened life span, usually less than 2 years. {ECO 0000269|PubMed 10581036, ECO 0000269|PubMed 10947946}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	S17A5_HUMAN	Salla disease (SD) [MIM 604369]  Sialic acid storage disease (SASD). SASDs are autosomal recessive neurodegenerative disorders characterized by hypotonia, cerebellar ataxia and mental retardation. They are caused by a defect in the metabolism of sialic acid which results in increased urinary excretion of unconjugated sialic acid, specifically N-acetylneuraminic acid. Enlarged lysosomes are seen on electron microscopic studies. Clinical symptoms of SD present usually at age less than 1 year and progression is slow. {ECO 0000269|PubMed 10581036, ECO 0000269|PubMed 10947946, ECO 0000269|PubMed 12794687, ECO 0000269|PubMed 21781115}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000355773	ENSP00000348019; ENSG00000119899. [Q9NRA2-1]
# FUNCTION	S17A5_HUMAN	Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential- dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva. {ECO 0000269|PubMed 10581036, ECO 0000269|PubMed 11751519, ECO 0000269|PubMed 15510212, ECO 0000269|PubMed 21781115, ECO 0000269|PubMed 22778404}. 
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:HPA.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030672	synaptic vesicle membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0015136	sialic acid transmembrane transporter activity; IDA:MGI.
# GO_function	S17A5_HUMAN	GO 0005351 sugar proton symporter activity; TAS ProtInc.
# GO_function	S17A5_HUMAN	GO 0015538 sialic acid proton symporter activity; TAS Reactome.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006820	anion transport; TAS:ProtInc.
# GO_process	GO:0006865	amino acid transport; IEA:UniProtKB-KW.
# GO_process	GO:0015739	sialic acid transport; IDA:MGI.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q9NRA2	HS
# HGNC	HGNC:10933	SLC17A5
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H00147	[Inherited metabolic disease] Sialuria, French type
# KEGG_Pathway	ko04142	Lysosome
# MIM	269920	phenotype
# MIM	604322	gene
# MIM	604369	phenotype
# Organism	S17A5_HUMAN	Homo sapiens (Human)
# Orphanet	309324	Free sialic acid storage disease, infantile form
# Orphanet	309331	Intermediate severe Salla disease
# Orphanet	309334	Salla disease
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-4085001	Sialic acid metabolism
# Reactome	R-HSA-428643	Organic anion transporters
# RecName	S17A5_HUMAN	Sialin
# RefSeq	NP_036566	NM_012434.4. [Q9NRA2-1]
# SEQUENCE CAUTION	Sequence=AAF97769.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S17A5_HUMAN	Cell membrane {ECO 0000269|PubMed 22778404}; Multi-pass membrane protein {ECO 0000269|PubMed 22778404}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO 0000269|PubMed 21781115}; Multi-pass membrane protein {ECO 0000269|PubMed 21781115}. Lysosome membrane {ECO 0000269|PubMed 17897319}; Multi-pass membrane protein {ECO 0000269|PubMed 17897319}. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.1.14.10	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	S17A5_HUMAN	Found in fetal lung and small intestine, and at lower level in fetal skin and muscle. In the adult, detected in placenta, kidney and pancreas. Abundant in the endothelial cells of tumors from ovary, colon, breast and lung, but is not detected in endothelial cells from the corresponding normal tissues. {ECO 0000269|PubMed 10581036, ECO 0000269|PubMed 11751519}. 
# UCSC	uc003phn	human. [Q9NRA2-1]
# eggNOG	ENOG410XPWC	LUCA
# eggNOG	KOG2532	Eukaryota
BLAST	swissprot:S17A5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S17A5_HUMAN
COXPRESdb	26503	http://coxpresdb.jp/data/gene/26503.shtml
CleanEx	HS_SLC17A5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC17A5
DOI	10.1002/ajmg.a.10246	http://dx.doi.org/10.1002/ajmg.a.10246
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/70585	http://dx.doi.org/10.1038/70585
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.emboj.7600464	http://dx.doi.org/10.1038/sj.emboj.7600464
DOI	10.1073/pnas.1116633109	http://dx.doi.org/10.1073/pnas.1116633109
DOI	10.1074/jbc.M110.130716	http://dx.doi.org/10.1074/jbc.M110.130716
DOI	10.1086/303077	http://dx.doi.org/10.1086/303077
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1471-4159.2011.07388.x	http://dx.doi.org/10.1111/j.1471-4159.2011.07388.x
DOI	10.1111/j.1600-0854.2007.00643.x	http://dx.doi.org/10.1111/j.1600-0854.2007.00643.x
EMBL	AF244577	http://www.ebi.ac.uk/ena/data/view/AF244577
EMBL	AJ387747	http://www.ebi.ac.uk/ena/data/view/AJ387747
EMBL	AK075320	http://www.ebi.ac.uk/ena/data/view/AK075320
EMBL	AL121972	http://www.ebi.ac.uk/ena/data/view/AL121972
EMBL	AL121972	http://www.ebi.ac.uk/ena/data/view/AL121972
EMBL	AL590428	http://www.ebi.ac.uk/ena/data/view/AL590428
EMBL	AL590428	http://www.ebi.ac.uk/ena/data/view/AL590428
EMBL	BC020961	http://www.ebi.ac.uk/ena/data/view/BC020961
Ensembl	ENST00000355773	http://www.ensembl.org/id/ENST00000355773
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030672	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030672
GO_function	GO:0005351	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005351
GO_function	GO:0015136	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015136
GO_function	GO:0015538	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015538
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006820	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006820
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GO_process	GO:0015739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015739
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC17A5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC17A5
GeneID	26503	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26503
GeneTree	ENSGT00760000119079	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119079
HGNC	HGNC:10933	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10933
HOGENOM	HOG000230811	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230811&db=HOGENOM6
HOVERGEN	HBG008834	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG008834&db=HOVERGEN
HPA	HPA044479	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA044479
InParanoid	Q9NRA2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NRA2
IntAct	Q9NRA2	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NRA2*
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	26503	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=26503
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00147	http://www.genome.jp/dbget-bin/www_bget?H00147
KEGG_Gene	hsa:26503	http://www.genome.jp/dbget-bin/www_bget?hsa:26503
KEGG_Orthology	KO:K12301	http://www.genome.jp/dbget-bin/www_bget?KO:K12301
KEGG_Pathway	ko04142	http://www.genome.jp/kegg-bin/show_pathway?ko04142
MIM	269920	http://www.ncbi.nlm.nih.gov/omim/269920
MIM	604322	http://www.ncbi.nlm.nih.gov/omim/604322
MIM	604369	http://www.ncbi.nlm.nih.gov/omim/604369
OMA	RSSPNED	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RSSPNED
Orphanet	309324	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=309324
Orphanet	309331	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=309331
Orphanet	309334	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=309334
OrthoDB	EOG091G06DG	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G06DG
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:S17A5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S17A5_HUMAN
PSORT-B	swissprot:S17A5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S17A5_HUMAN
PSORT2	swissprot:S17A5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S17A5_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA35824	http://www.pharmgkb.org/do/serve?objId=PA35824&objCls=Gene
Phobius	swissprot:S17A5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S17A5_HUMAN
PhylomeDB	Q9NRA2	http://phylomedb.org/?seqid=Q9NRA2
ProteinModelPortal	Q9NRA2	http://www.proteinmodelportal.org/query/uniprot/Q9NRA2
PubMed	10581036	http://www.ncbi.nlm.nih.gov/pubmed/10581036
PubMed	10947946	http://www.ncbi.nlm.nih.gov/pubmed/10947946
PubMed	11751519	http://www.ncbi.nlm.nih.gov/pubmed/11751519
PubMed	12794687	http://www.ncbi.nlm.nih.gov/pubmed/12794687
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15510212	http://www.ncbi.nlm.nih.gov/pubmed/15510212
PubMed	17897319	http://www.ncbi.nlm.nih.gov/pubmed/17897319
PubMed	20424173	http://www.ncbi.nlm.nih.gov/pubmed/20424173
PubMed	21781115	http://www.ncbi.nlm.nih.gov/pubmed/21781115
PubMed	22778404	http://www.ncbi.nlm.nih.gov/pubmed/22778404
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
Reactome	R-HSA-4085001	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-4085001
Reactome	R-HSA-428643	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428643
RefSeq	NP_036566	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_036566
STRING	9606.ENSP00000348019	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000348019&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.14.10	http://www.tcdb.org/search/result.php?tc=2.A.1.14.10
UCSC	uc003phn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003phn&org=rat
UniGene	Hs.597422	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.597422
UniProtKB	S17A5_HUMAN	http://www.uniprot.org/uniprot/S17A5_HUMAN
UniProtKB-AC	Q9NRA2	http://www.uniprot.org/uniprot/Q9NRA2
charge	swissprot:S17A5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S17A5_HUMAN
eggNOG	ENOG410XPWC	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPWC
eggNOG	KOG2532	http://eggnogapi.embl.de/nog_data/html/tree/KOG2532
epestfind	swissprot:S17A5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S17A5_HUMAN
garnier	swissprot:S17A5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S17A5_HUMAN
helixturnhelix	swissprot:S17A5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S17A5_HUMAN
hmoment	swissprot:S17A5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S17A5_HUMAN
iep	swissprot:S17A5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S17A5_HUMAN
inforesidue	swissprot:S17A5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S17A5_HUMAN
neXtProt	NX_Q9NRA2	http://www.nextprot.org/db/entry/NX_Q9NRA2
octanol	swissprot:S17A5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S17A5_HUMAN
pepcoil	swissprot:S17A5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S17A5_HUMAN
pepdigest	swissprot:S17A5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S17A5_HUMAN
pepinfo	swissprot:S17A5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S17A5_HUMAN
pepnet	swissprot:S17A5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S17A5_HUMAN
pepstats	swissprot:S17A5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S17A5_HUMAN
pepwheel	swissprot:S17A5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S17A5_HUMAN
pepwindow	swissprot:S17A5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S17A5_HUMAN
sigcleave	swissprot:S17A5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S17A5_HUMAN
## Database	ID	URL or Descriptions
# AltName	MRP2_HUMAN	ATP-binding cassette sub-family C member 2
# AltName	MRP2_HUMAN	Canalicular multidrug resistance protein
# AltName	MRP2_HUMAN	Multidrug resistance-associated protein 2
# BioGrid	107647	45
# ChiTaRS	ABCC2	human
# DISEASE	MRP2_HUMAN	Dubin-Johnson syndrome (DJS) [MIM 237500]  Autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function. {ECO 0000269|PubMed 10053008, ECO 0000269|PubMed 10464142, ECO 0000269|PubMed 11266082, ECO 0000269|PubMed 11477083, ECO 0000269|PubMed 25336012, ECO 0000269|PubMed 9425227}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00067	Vasopressin
# DrugBank	DB00091	Cyclosporine
# DrugBank	DB00116	Tetrahydrofolic acid
# DrugBank	DB00143	Glutathione
# DrugBank	DB00171	Adenosine triphosphate
# DrugBank	DB00175	Pravastatin
# DrugBank	DB00206	Reserpine
# DrugBank	DB00224	Indinavir
# DrugBank	DB00227	Lovastatin
# DrugBank	DB00252	Phenytoin
# DrugBank	DB00257	Clotrimazole
# DrugBank	DB00275	Olmesartan
# DrugBank	DB00286	Conjugated Estrogens
# DrugBank	DB00300	Tenofovir
# DrugBank	DB00328	Indomethacin
# DrugBank	DB00345	Aminohippurate
# DrugBank	DB00398	Sorafenib
# DrugBank	DB00421	Spironolactone
# DrugBank	DB00503	Ritonavir
# DrugBank	DB00515	Cisplatin
# DrugBank	DB00526	Oxaliplatin
# DrugBank	DB00541	Vincristine
# DrugBank	DB00563	Methotrexate
# DrugBank	DB00564	Carbamazepine
# DrugBank	DB00570	Vinblastine
# DrugBank	DB00602	Ivermectin
# DrugBank	DB00641	Simvastatin
# DrugBank	DB00650	Leucovorin
# DrugBank	DB00661	Verapamil
# DrugBank	DB00675	Tamoxifen
# DrugBank	DB00688	Mycophenolate mofetil
# DrugBank	DB00694	Daunorubicin
# DrugBank	DB00695	Furosemide
# DrugBank	DB00709	Lamivudine
# DrugBank	DB00762	Irinotecan
# DrugBank	DB00773	Etoposide
# DrugBank	DB00795	Sulfasalazine
# DrugBank	DB00876	Eprosartan
# DrugBank	DB00908	Quinidine
# DrugBank	DB00957	Norgestimate
# DrugBank	DB00958	Carboplatin
# DrugBank	DB00966	Telmisartan
# DrugBank	DB00973	Ezetimibe
# DrugBank	DB00977	Ethinyl Estradiol
# DrugBank	DB00978	Lomefloxacin
# DrugBank	DB00997	Doxorubicin
# DrugBank	DB01016	Glyburide
# DrugBank	DB01032	Probenecid
# DrugBank	DB01045	Rifampicin
# DrugBank	DB01076	Atorvastatin
# DrugBank	DB01115	Nifedipine
# DrugBank	DB01138	Sulfinpyrazone
# DrugBank	DB01165	Ofloxacin
# DrugBank	DB01169	Arsenic trioxide
# DrugBank	DB01174	Phenobarbital
# DrugBank	DB01202	Levetiracetam
# DrugBank	DB01208	Sparfloxacin
# DrugBank	DB01229	Paclitaxel
# DrugBank	DB01232	Saquinavir
# DrugBank	DB01234	Dexamethasone
# DrugBank	DB01248	Docetaxel
# DrugBank	DB01268	Sunitinib
# DrugBank	DB01411	Pranlukast
# DrugBank	DB01586	Ursodeoxycholic acid
# DrugBank	DB02659	Cholic Acid
# DrugBank	DB02703	Fusidic Acid
# DrugBank	DB08860	Pitavastatin
# DrugBank	DB08884	Gadoxetate
# DrugBank	DB08907	Canagliflozin
# DrugBank	DB09060	Avibactam
# DrugBank	DB09272	Eluxadoline
# Ensembl	ENST00000370449	ENSP00000359478; ENSG00000023839
# ExpressionAtlas	Q92887	baseline and differential
# FUNCTION	MRP2_HUMAN	Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0009986	cell surface; IDA:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_component	GO:0046581	intercellular canaliculus; IEA:Ensembl.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0008514	organic anion transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0015127	bilirubin transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; TAS:ProtInc.
# GO_function	GO:0043225	ATPase-coupled anion transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006855	drug transmembrane transport; IEA:Ensembl.
# GO_process	GO:0006979	response to oxidative stress; IEA:Ensembl.
# GO_process	GO:0009408	response to heat; IEA:Ensembl.
# GO_process	GO:0015732	prostaglandin transport; IEA:Ensembl.
# GO_process	GO:0030644	cellular chloride ion homeostasis; IEA:Ensembl.
# GO_process	GO:0031427	response to methotrexate; IEA:Ensembl.
# GO_process	GO:0043627	response to estrogen; IEA:Ensembl.
# GO_process	GO:0046685	response to arsenic-containing substance; IEA:Ensembl.
# GO_process	GO:0048545	response to steroid hormone; IEA:Ensembl.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GO_process	GO:0070327	thyroid hormone transport; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 2.
# Genevisible	Q92887	HS
# HGNC	HGNC:53	ABCC2
# INTERACTION	MRP2_HUMAN	P19838 NFKB1; NbExp=3; IntAct=EBI-3916193, EBI-300010; 
# IntAct	Q92887	5
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR005292	Multidrug-R_assoc
# InterPro	IPR011527	ABC1_TM_dom
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR027417	P-loop_NTPase
# InterPro	IPR030247	ABCC2
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Disease	H00208	[Inherited metabolic disease; Liver disease] Dubin-Johnson syndrome (DJS)
# KEGG_Pathway	ko02010	ABC transporters
# KEGG_Pathway	ko04976	Bile secretion
# MIM	237500	phenotype
# MIM	601107	gene
# Organism	MRP2_HUMAN	Homo sapiens (Human)
# Orphanet	234	Dubin-Johnson syndrome
# PANTHER	PTHR24223:SF176	PTHR24223:SF176; 2
# PIR	S71841	S71841
# PROSITE	PS00211	ABC_TRANSPORTER_1
# PROSITE	PS50893	ABC_TRANSPORTER_2; 2
# PROSITE	PS50929	ABC_TM1F; 2
# Pfam	PF00005	ABC_tran; 2
# Pfam	PF00664	ABC_membrane; 2
# Proteomes	UP000005640	Chromosome 10
# Reactome	R-HSA-382556	ABC-family proteins mediated transport
# RecName	MRP2_HUMAN	Canalicular multispecific organic anion transporter 1
# RefSeq	NP_000383	NM_000392.4
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 2 ABC transmembrane type-1 domains. {ECO:0000255|PROSITE-ProRule	PRU00441}. 
# SIMILARITY	Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA; 2
# SUBCELLULAR LOCATION	MRP2_HUMAN	Apical cell membrane {ECO 0000269|PubMed 11093739}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00441, ECO 0000269|PubMed 11093739}. 
# SUPFAM	SSF52540	SSF52540; 2
# SUPFAM	SSF90123	SSF90123; 2
# TCDB	3.A.1.208	the atp-binding cassette (abc) superfamily
# TIGRFAMs	TIGR00957	MRP_assoc_pro
# TISSUE SPECIFICITY	MRP2_HUMAN	Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver. 
# UCSC	uc001kqf	human
# WEB RESOURCE	MRP2_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=Q92887";
# eggNOG	COG1132	LUCA
# eggNOG	KOG0054	Eukaryota
BLAST	swissprot:MRP2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MRP2_HUMAN
BioCyc	ZFISH:ENSG00000023839-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000023839-MONOMER
COXPRESdb	1244	http://coxpresdb.jp/data/gene/1244.shtml
CleanEx	HS_ABCC2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCC2
DOI	10.1002/humu.22041	http://dx.doi.org/10.1002/humu.22041
DOI	10.1016/S0016-5085(99)70459-2	http://dx.doi.org/10.1016/S0016-5085(99)70459-2
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature02462	http://dx.doi.org/10.1038/nature02462
DOI	10.1053/jhep.2000.19791	http://dx.doi.org/10.1053/jhep.2000.19791
DOI	10.1055/s-2000-9391	http://dx.doi.org/10.1055/s-2000-9391
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/jbc.271.25.15091	http://dx.doi.org/10.1074/jbc.271.25.15091
DOI	10.1074/jbc.M105047200	http://dx.doi.org/10.1074/jbc.M105047200
DOI	10.1074/jbc.M105160200	http://dx.doi.org/10.1074/jbc.M105160200
DOI	10.1086/302292	http://dx.doi.org/10.1086/302292
DOI	10.1093/hmg/7.2.203	http://dx.doi.org/10.1093/hmg/7.2.203
DOI	10.1097/00008571-200103000-00008	http://dx.doi.org/10.1097/00008571-200103000-00008
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/ped.12404	http://dx.doi.org/10.1111/ped.12404
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DrugBank	DB00067	http://www.drugbank.ca/drugs/DB00067
DrugBank	DB00091	http://www.drugbank.ca/drugs/DB00091
DrugBank	DB00116	http://www.drugbank.ca/drugs/DB00116
DrugBank	DB00143	http://www.drugbank.ca/drugs/DB00143
DrugBank	DB00171	http://www.drugbank.ca/drugs/DB00171
DrugBank	DB00175	http://www.drugbank.ca/drugs/DB00175
DrugBank	DB00206	http://www.drugbank.ca/drugs/DB00206
DrugBank	DB00224	http://www.drugbank.ca/drugs/DB00224
DrugBank	DB00227	http://www.drugbank.ca/drugs/DB00227
DrugBank	DB00252	http://www.drugbank.ca/drugs/DB00252
DrugBank	DB00257	http://www.drugbank.ca/drugs/DB00257
DrugBank	DB00275	http://www.drugbank.ca/drugs/DB00275
DrugBank	DB00286	http://www.drugbank.ca/drugs/DB00286
DrugBank	DB00300	http://www.drugbank.ca/drugs/DB00300
DrugBank	DB00328	http://www.drugbank.ca/drugs/DB00328
DrugBank	DB00345	http://www.drugbank.ca/drugs/DB00345
DrugBank	DB00398	http://www.drugbank.ca/drugs/DB00398
DrugBank	DB00421	http://www.drugbank.ca/drugs/DB00421
DrugBank	DB00503	http://www.drugbank.ca/drugs/DB00503
DrugBank	DB00515	http://www.drugbank.ca/drugs/DB00515
DrugBank	DB00526	http://www.drugbank.ca/drugs/DB00526
DrugBank	DB00541	http://www.drugbank.ca/drugs/DB00541
DrugBank	DB00563	http://www.drugbank.ca/drugs/DB00563
DrugBank	DB00564	http://www.drugbank.ca/drugs/DB00564
DrugBank	DB00570	http://www.drugbank.ca/drugs/DB00570
DrugBank	DB00602	http://www.drugbank.ca/drugs/DB00602
DrugBank	DB00641	http://www.drugbank.ca/drugs/DB00641
DrugBank	DB00650	http://www.drugbank.ca/drugs/DB00650
DrugBank	DB00661	http://www.drugbank.ca/drugs/DB00661
DrugBank	DB00675	http://www.drugbank.ca/drugs/DB00675
DrugBank	DB00688	http://www.drugbank.ca/drugs/DB00688
DrugBank	DB00694	http://www.drugbank.ca/drugs/DB00694
DrugBank	DB00695	http://www.drugbank.ca/drugs/DB00695
DrugBank	DB00709	http://www.drugbank.ca/drugs/DB00709
DrugBank	DB00762	http://www.drugbank.ca/drugs/DB00762
DrugBank	DB00773	http://www.drugbank.ca/drugs/DB00773
DrugBank	DB00795	http://www.drugbank.ca/drugs/DB00795
DrugBank	DB00876	http://www.drugbank.ca/drugs/DB00876
DrugBank	DB00908	http://www.drugbank.ca/drugs/DB00908
DrugBank	DB00957	http://www.drugbank.ca/drugs/DB00957
DrugBank	DB00958	http://www.drugbank.ca/drugs/DB00958
DrugBank	DB00966	http://www.drugbank.ca/drugs/DB00966
DrugBank	DB00973	http://www.drugbank.ca/drugs/DB00973
DrugBank	DB00977	http://www.drugbank.ca/drugs/DB00977
DrugBank	DB00978	http://www.drugbank.ca/drugs/DB00978
DrugBank	DB00997	http://www.drugbank.ca/drugs/DB00997
DrugBank	DB01016	http://www.drugbank.ca/drugs/DB01016
DrugBank	DB01032	http://www.drugbank.ca/drugs/DB01032
DrugBank	DB01045	http://www.drugbank.ca/drugs/DB01045
DrugBank	DB01076	http://www.drugbank.ca/drugs/DB01076
DrugBank	DB01115	http://www.drugbank.ca/drugs/DB01115
DrugBank	DB01138	http://www.drugbank.ca/drugs/DB01138
DrugBank	DB01165	http://www.drugbank.ca/drugs/DB01165
DrugBank	DB01169	http://www.drugbank.ca/drugs/DB01169
DrugBank	DB01174	http://www.drugbank.ca/drugs/DB01174
DrugBank	DB01202	http://www.drugbank.ca/drugs/DB01202
DrugBank	DB01208	http://www.drugbank.ca/drugs/DB01208
DrugBank	DB01229	http://www.drugbank.ca/drugs/DB01229
DrugBank	DB01232	http://www.drugbank.ca/drugs/DB01232
DrugBank	DB01234	http://www.drugbank.ca/drugs/DB01234
DrugBank	DB01248	http://www.drugbank.ca/drugs/DB01248
DrugBank	DB01268	http://www.drugbank.ca/drugs/DB01268
DrugBank	DB01411	http://www.drugbank.ca/drugs/DB01411
DrugBank	DB01586	http://www.drugbank.ca/drugs/DB01586
DrugBank	DB02659	http://www.drugbank.ca/drugs/DB02659
DrugBank	DB02703	http://www.drugbank.ca/drugs/DB02703
DrugBank	DB08860	http://www.drugbank.ca/drugs/DB08860
DrugBank	DB08884	http://www.drugbank.ca/drugs/DB08884
DrugBank	DB08907	http://www.drugbank.ca/drugs/DB08907
DrugBank	DB09060	http://www.drugbank.ca/drugs/DB09060
DrugBank	DB09272	http://www.drugbank.ca/drugs/DB09272
EMBL	AJ132244	http://www.ebi.ac.uk/ena/data/view/AJ132244
EMBL	AJ132287	http://www.ebi.ac.uk/ena/data/view/AJ132287
EMBL	AJ132288	http://www.ebi.ac.uk/ena/data/view/AJ132288
EMBL	AJ132289	http://www.ebi.ac.uk/ena/data/view/AJ132289
EMBL	AJ132290	http://www.ebi.ac.uk/ena/data/view/AJ132290
EMBL	AJ132291	http://www.ebi.ac.uk/ena/data/view/AJ132291
EMBL	AJ132292	http://www.ebi.ac.uk/ena/data/view/AJ132292
EMBL	AJ132293	http://www.ebi.ac.uk/ena/data/view/AJ132293
EMBL	AJ132294	http://www.ebi.ac.uk/ena/data/view/AJ132294
EMBL	AJ132295	http://www.ebi.ac.uk/ena/data/view/AJ132295
EMBL	AJ132296	http://www.ebi.ac.uk/ena/data/view/AJ132296
EMBL	AJ132297	http://www.ebi.ac.uk/ena/data/view/AJ132297
EMBL	AJ132298	http://www.ebi.ac.uk/ena/data/view/AJ132298
EMBL	AJ132299	http://www.ebi.ac.uk/ena/data/view/AJ132299
EMBL	AJ132300	http://www.ebi.ac.uk/ena/data/view/AJ132300
EMBL	AJ132301	http://www.ebi.ac.uk/ena/data/view/AJ132301
EMBL	AJ132302	http://www.ebi.ac.uk/ena/data/view/AJ132302
EMBL	AJ132303	http://www.ebi.ac.uk/ena/data/view/AJ132303
EMBL	AJ132304	http://www.ebi.ac.uk/ena/data/view/AJ132304
EMBL	AJ132305	http://www.ebi.ac.uk/ena/data/view/AJ132305
EMBL	AJ132306	http://www.ebi.ac.uk/ena/data/view/AJ132306
EMBL	AJ132307	http://www.ebi.ac.uk/ena/data/view/AJ132307
EMBL	AJ132308	http://www.ebi.ac.uk/ena/data/view/AJ132308
EMBL	AJ132309	http://www.ebi.ac.uk/ena/data/view/AJ132309
EMBL	AJ132310	http://www.ebi.ac.uk/ena/data/view/AJ132310
EMBL	AJ132311	http://www.ebi.ac.uk/ena/data/view/AJ132311
EMBL	AJ132312	http://www.ebi.ac.uk/ena/data/view/AJ132312
EMBL	AJ132313	http://www.ebi.ac.uk/ena/data/view/AJ132313
EMBL	AJ132314	http://www.ebi.ac.uk/ena/data/view/AJ132314
EMBL	AJ245625	http://www.ebi.ac.uk/ena/data/view/AJ245625
EMBL	AJ245626	http://www.ebi.ac.uk/ena/data/view/AJ245626
EMBL	AJ245627	http://www.ebi.ac.uk/ena/data/view/AJ245627
EMBL	AL133353	http://www.ebi.ac.uk/ena/data/view/AL133353
EMBL	AL133353	http://www.ebi.ac.uk/ena/data/view/AL133353
EMBL	AL392107	http://www.ebi.ac.uk/ena/data/view/AL392107
EMBL	AL392107	http://www.ebi.ac.uk/ena/data/view/AL392107
EMBL	BC136419	http://www.ebi.ac.uk/ena/data/view/BC136419
EMBL	CH471066	http://www.ebi.ac.uk/ena/data/view/CH471066
EMBL	U49248	http://www.ebi.ac.uk/ena/data/view/U49248
EMBL	U63970	http://www.ebi.ac.uk/ena/data/view/U63970
EMBL	X96395	http://www.ebi.ac.uk/ena/data/view/X96395
Ensembl	ENST00000370449	http://www.ensembl.org/id/ENST00000370449
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0046581	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046581
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0008514	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008514
GO_function	GO:0015127	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015127
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GO_function	GO:0043225	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043225
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006855	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006855
GO_process	GO:0006979	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979
GO_process	GO:0009408	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408
GO_process	GO:0015732	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015732
GO_process	GO:0030644	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030644
GO_process	GO:0031427	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031427
GO_process	GO:0043627	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043627
GO_process	GO:0046685	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046685
GO_process	GO:0048545	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048545
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GO_process	GO:0070327	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070327
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCC2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCC2
GeneID	1244	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1244
GeneTree	ENSGT00860000133687	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00860000133687
HGNC	HGNC:53	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:53
HOVERGEN	HBG108314	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108314&db=HOVERGEN
HPA	CAB037271	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB037271
HPA	HPA004860	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA004860
InParanoid	Q92887	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q92887
IntAct	Q92887	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q92887*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR005292	http://www.ebi.ac.uk/interpro/entry/IPR005292
InterPro	IPR011527	http://www.ebi.ac.uk/interpro/entry/IPR011527
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
InterPro	IPR030247	http://www.ebi.ac.uk/interpro/entry/IPR030247
Jabion	1244	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1244
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Disease	H00208	http://www.genome.jp/dbget-bin/www_bget?H00208
KEGG_Gene	hsa:1244	http://www.genome.jp/dbget-bin/www_bget?hsa:1244
KEGG_Orthology	KO:K05666	http://www.genome.jp/dbget-bin/www_bget?KO:K05666
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
MIM	237500	http://www.ncbi.nlm.nih.gov/omim/237500
MIM	601107	http://www.ncbi.nlm.nih.gov/omim/601107
MINT	MINT-5004989	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5004989
OMA	QTPGPFY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QTPGPFY
Orphanet	234	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=234
OrthoDB	EOG091G00IN	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00IN
PANTHER	PTHR24223:SF176	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24223:SF176
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PROSITE	PS50929	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929
PSORT	swissprot:MRP2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MRP2_HUMAN
PSORT-B	swissprot:MRP2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MRP2_HUMAN
PSORT2	swissprot:MRP2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MRP2_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF00664	http://pfam.xfam.org/family/PF00664
PharmGKB	PA116	http://www.pharmgkb.org/do/serve?objId=PA116&objCls=Gene
Phobius	swissprot:MRP2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MRP2_HUMAN
PhylomeDB	Q92887	http://phylomedb.org/?seqid=Q92887
ProteinModelPortal	Q92887	http://www.proteinmodelportal.org/query/uniprot/Q92887
PubMed	10053008	http://www.ncbi.nlm.nih.gov/pubmed/10053008
PubMed	10464142	http://www.ncbi.nlm.nih.gov/pubmed/10464142
PubMed	11076395	http://www.ncbi.nlm.nih.gov/pubmed/11076395
PubMed	11093739	http://www.ncbi.nlm.nih.gov/pubmed/11093739
PubMed	11266082	http://www.ncbi.nlm.nih.gov/pubmed/11266082
PubMed	11477083	http://www.ncbi.nlm.nih.gov/pubmed/11477083
PubMed	11500505	http://www.ncbi.nlm.nih.gov/pubmed/11500505
PubMed	15164054	http://www.ncbi.nlm.nih.gov/pubmed/15164054
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22290738	http://www.ncbi.nlm.nih.gov/pubmed/22290738
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25336012	http://www.ncbi.nlm.nih.gov/pubmed/25336012
PubMed	8662992	http://www.ncbi.nlm.nih.gov/pubmed/8662992
PubMed	8797578	http://www.ncbi.nlm.nih.gov/pubmed/8797578
PubMed	9425227	http://www.ncbi.nlm.nih.gov/pubmed/9425227
Reactome	R-HSA-382556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-382556
RefSeq	NP_000383	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000383
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	Q92887	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q92887
STRING	9606.ENSP00000359478	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000359478&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
SUPFAM	SSF90123	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123
TCDB	3.A.1.208	http://www.tcdb.org/search/result.php?tc=3.A.1.208
TIGRFAMs	TIGR00957	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00957
UCSC	uc001kqf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001kqf&org=rat
UniGene	Hs.368243	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.368243
UniProtKB	MRP2_HUMAN	http://www.uniprot.org/uniprot/MRP2_HUMAN
UniProtKB-AC	Q92887	http://www.uniprot.org/uniprot/Q92887
charge	swissprot:MRP2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MRP2_HUMAN
eggNOG	COG1132	http://eggnogapi.embl.de/nog_data/html/tree/COG1132
eggNOG	KOG0054	http://eggnogapi.embl.de/nog_data/html/tree/KOG0054
epestfind	swissprot:MRP2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MRP2_HUMAN
garnier	swissprot:MRP2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MRP2_HUMAN
helixturnhelix	swissprot:MRP2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MRP2_HUMAN
hmoment	swissprot:MRP2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MRP2_HUMAN
iep	swissprot:MRP2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MRP2_HUMAN
inforesidue	swissprot:MRP2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MRP2_HUMAN
neXtProt	NX_Q92887	http://www.nextprot.org/db/entry/NX_Q92887
octanol	swissprot:MRP2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MRP2_HUMAN
pepcoil	swissprot:MRP2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MRP2_HUMAN
pepdigest	swissprot:MRP2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MRP2_HUMAN
pepinfo	swissprot:MRP2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MRP2_HUMAN
pepnet	swissprot:MRP2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MRP2_HUMAN
pepstats	swissprot:MRP2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MRP2_HUMAN
pepwheel	swissprot:MRP2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MRP2_HUMAN
pepwindow	swissprot:MRP2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MRP2_HUMAN
sigcleave	swissprot:MRP2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MRP2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=delta1; IsoId=P51172-1; Sequence=Displayed; Name=2; Synonyms=delta2; IsoId=P51172-2; Sequence=VSP_007725; Note=Channels including isoform 2 exhibit greater conductance than those containing isoform 1. Ref.2 (ABI64069) sequence is in conflict in position: 78	T->A. {ECO:0000305}; 
# AltName	SCNND_HUMAN	Delta-NaCH
# AltName	SCNND_HUMAN	Epithelial Na(+) channel subunit delta
# AltName	SCNND_HUMAN	Nonvoltage-gated sodium channel 1 subunit delta
# AltName	SCNND_HUMAN	SCNED
# BioGrid	112243	21
# DrugBank	DB00384	Triamterene
# DrugBank	DB00594	Amiloride
# Ensembl	ENST00000325425	ENSP00000321594; ENSG00000162572. [P51172-2]
# Ensembl	ENST00000338555	ENSP00000339504; ENSG00000162572. [P51172-1]
# Ensembl	ENST00000400928	ENSP00000383717; ENSG00000162572. [P51172-1]
# ExpressionAtlas	P51172	baseline and differential
# FUNCTION	SCNND_HUMAN	Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. {ECO 0000269|PubMed 16423824, ECO 0000269|PubMed 7499195}. 
# GO_component	GO:0005886	plasma membrane; IDA:HPA.
# GO_component	GO:0015629	actin cytoskeleton; IDA:HPA.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015280	ligand-gated sodium channel activity; TAS:ProtInc.
# GO_process	GO:0006814	sodium ion transport; TAS:ProtInc.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0050896	response to stimulus; IEA:UniProtKB-KW.
# GO_process	GO:0050909	sensory perception of taste; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005856	cytoskeleton
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P51172	HS
# HGNC	HGNC:10601	SCNN1D
# INTERACTION	SCNND_HUMAN	Q8N668 COMMD1; NbExp=3; IntAct=EBI-2547114, EBI-1550112; 
# IntAct	P51172	3
# InterPro	IPR001873	Na+channel_ASC
# InterPro	IPR004724	ENaC
# InterPro	IPR020903	Na+channel_ASC_CS
# KEGG_Brite	ko04040	Ion channels
# MIM	601328	gene
# Organism	SCNND_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11690	PTHR11690
# PIR	I39196	I39196
# PRINTS	PR01078	AMINACHANNEL
# PROSITE	PS01206	ASC
# Pfam	PF00858	ASC
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	SCNND_HUMAN	Amiloride-sensitive sodium channel subunit delta
# RefSeq	NP_001123885	NM_001130413.3
# RefSeq	XP_011540227	XM_011541925.2. [P51172-2]
# RefSeq	XP_011540234	XM_011541932.2. [P51172-1]
# RefSeq	XP_011540235	XM_011541933.2. [P51172-1]
# SIMILARITY	Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1D subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	SCNND_HUMAN	Cell membrane {ECO 0000269|PubMed 19520916}; Multi-pass membrane protein {ECO 0000269|PubMed 19520916}. 
# SUBUNIT	SCNND_HUMAN	Heterotrimer containing a delta/SCNN1D, a beta/SCNN1B and a gamma/SCNN1G subunit. The additional delta/SCNN1D subunit exists only in some organisms and can replace the alpha/SCNN1A subunit to form an alternative channel with specific properties. {ECO 0000269|PubMed 16423824, ECO 0000269|PubMed 7499195}. 
# TCDB	1.A.6.1	the epithelial na(+) channel (enac) family
# TIGRFAMs	TIGR00859	ENaC
# UCSC	uc001adw	human. [P51172-1]
# eggNOG	ENOG410ZNFK	LUCA
# eggNOG	KOG4294	Eukaryota
BLAST	swissprot:SCNND_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SCNND_HUMAN
BioCyc	ZFISH:ENSG00000162572-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000162572-MONOMER
COXPRESdb	6339	http://coxpresdb.jp/data/gene/6339.shtml
CleanEx	HS_SCNN1D	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SCNN1D
DOI	10.1016/j.gene.2015.12.061	http://dx.doi.org/10.1016/j.gene.2015.12.061
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.270.46.27411	http://dx.doi.org/10.1074/jbc.270.46.27411
DOI	10.1074/jbc.M512293200	http://dx.doi.org/10.1074/jbc.M512293200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1152/ajplung.00331.2011	http://dx.doi.org/10.1152/ajplung.00331.2011
DOI	10.1165/rcmb.2009-0053OC	http://dx.doi.org/10.1165/rcmb.2009-0053OC
DrugBank	DB00384	http://www.drugbank.ca/drugs/DB00384
DrugBank	DB00594	http://www.drugbank.ca/drugs/DB00594
EMBL	AK093239	http://www.ebi.ac.uk/ena/data/view/AK093239
EMBL	AK127357	http://www.ebi.ac.uk/ena/data/view/AK127357
EMBL	AL162741	http://www.ebi.ac.uk/ena/data/view/AL162741
EMBL	AL162741	http://www.ebi.ac.uk/ena/data/view/AL162741
EMBL	BC036752	http://www.ebi.ac.uk/ena/data/view/BC036752
EMBL	BC125074	http://www.ebi.ac.uk/ena/data/view/BC125074
EMBL	DQ898176	http://www.ebi.ac.uk/ena/data/view/DQ898176
EMBL	EU489064	http://www.ebi.ac.uk/ena/data/view/EU489064
EMBL	U38254	http://www.ebi.ac.uk/ena/data/view/U38254
Ensembl	ENST00000325425	http://www.ensembl.org/id/ENST00000325425
Ensembl	ENST00000338555	http://www.ensembl.org/id/ENST00000338555
Ensembl	ENST00000400928	http://www.ensembl.org/id/ENST00000400928
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0015629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015629
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015280	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015280
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0050896	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050896
GO_process	GO:0050909	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050909
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SCNN1D	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SCNN1D
GeneID	6339	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6339
GeneTree	ENSGT00760000119120	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119120
H-InvDB	HIX0000018	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0000018
HGNC	HGNC:10601	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10601
HOGENOM	HOG000236286	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236286&db=HOGENOM6
HOVERGEN	HBG058435	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG058435&db=HOVERGEN
HPA	CAB009540	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB009540
HPA	HPA026884	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA026884
InParanoid	P51172	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P51172
IntAct	P51172	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P51172*
InterPro	IPR001873	http://www.ebi.ac.uk/interpro/entry/IPR001873
InterPro	IPR004724	http://www.ebi.ac.uk/interpro/entry/IPR004724
InterPro	IPR020903	http://www.ebi.ac.uk/interpro/entry/IPR020903
Jabion	6339	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6339
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:6339	http://www.genome.jp/dbget-bin/www_bget?hsa:6339
KEGG_Orthology	KO:K04826	http://www.genome.jp/dbget-bin/www_bget?KO:K04826
MIM	601328	http://www.ncbi.nlm.nih.gov/omim/601328
PANTHER	PTHR11690	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11690
PRINTS	PR01078	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01078
PROSITE	PS01206	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01206
PSORT	swissprot:SCNND_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SCNND_HUMAN
PSORT-B	swissprot:SCNND_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SCNND_HUMAN
PSORT2	swissprot:SCNND_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SCNND_HUMAN
Pfam	PF00858	http://pfam.xfam.org/family/PF00858
PharmGKB	PA35011	http://www.pharmgkb.org/do/serve?objId=PA35011&objCls=Gene
Phobius	swissprot:SCNND_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SCNND_HUMAN
PhylomeDB	P51172	http://phylomedb.org/?seqid=P51172
ProteinModelPortal	P51172	http://www.proteinmodelportal.org/query/uniprot/P51172
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16423824	http://www.ncbi.nlm.nih.gov/pubmed/16423824
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	19520916	http://www.ncbi.nlm.nih.gov/pubmed/19520916
PubMed	22505667	http://www.ncbi.nlm.nih.gov/pubmed/22505667
PubMed	26772908	http://www.ncbi.nlm.nih.gov/pubmed/26772908
PubMed	7499195	http://www.ncbi.nlm.nih.gov/pubmed/7499195
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_001123885	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001123885
RefSeq	XP_011540227	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011540227
RefSeq	XP_011540234	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011540234
RefSeq	XP_011540235	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011540235
STRING	9606.ENSP00000368411	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000368411&targetmode=cogs
TCDB	1.A.6.1	http://www.tcdb.org/search/result.php?tc=1.A.6.1
TIGRFAMs	TIGR00859	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00859
UCSC	uc001adw	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001adw&org=rat
UniGene	Hs.512681	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.512681
UniProtKB	SCNND_HUMAN	http://www.uniprot.org/uniprot/SCNND_HUMAN
UniProtKB-AC	P51172	http://www.uniprot.org/uniprot/P51172
charge	swissprot:SCNND_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SCNND_HUMAN
eggNOG	ENOG410ZNFK	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZNFK
eggNOG	KOG4294	http://eggnogapi.embl.de/nog_data/html/tree/KOG4294
epestfind	swissprot:SCNND_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SCNND_HUMAN
garnier	swissprot:SCNND_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SCNND_HUMAN
helixturnhelix	swissprot:SCNND_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SCNND_HUMAN
hmoment	swissprot:SCNND_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SCNND_HUMAN
iep	swissprot:SCNND_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SCNND_HUMAN
inforesidue	swissprot:SCNND_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SCNND_HUMAN
neXtProt	NX_P51172	http://www.nextprot.org/db/entry/NX_P51172
octanol	swissprot:SCNND_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SCNND_HUMAN
pepcoil	swissprot:SCNND_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SCNND_HUMAN
pepdigest	swissprot:SCNND_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SCNND_HUMAN
pepinfo	swissprot:SCNND_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SCNND_HUMAN
pepnet	swissprot:SCNND_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SCNND_HUMAN
pepstats	swissprot:SCNND_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SCNND_HUMAN
pepwheel	swissprot:SCNND_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SCNND_HUMAN
pepwindow	swissprot:SCNND_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SCNND_HUMAN
sigcleave	swissprot:SCNND_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SCNND_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S38A5_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8WUX1-1; Sequence=Displayed; Name=2; IsoId=Q8WUX1-2; Sequence=VSP_029702; Note=No experimental confirmation available.; 
# AltName	S38A5_HUMAN	Solute carrier family 38 member 5
# AltName	S38A5_HUMAN	System N transporter 2
# BIOPHYSICOCHEMICAL PROPERTIES	Kinetic parameters: KM=0.6 mM for histidine (at pH 8.0) {ECO	0000269|PubMed:11243884}; 
# BioGrid	124974	8
# CCDS	CCDS14293	-. [Q8WUX1-1]
# ChiTaRS	SLC38A5	human
# ENZYME REGULATION	Not inhibited by lithium. {ECO:0000269|PubMed	11243884}. 
# Ensembl	ENST00000595796	ENSP00000471683; ENSG00000017483. [Q8WUX1-1]
# Ensembl	ENST00000619100	ENSP00000478807; ENSG00000017483. [Q8WUX1-2]
# Ensembl	ENST00000620913	ENSP00000481291; ENSG00000017483. [Q8WUX1-1]
# ExpressionAtlas	Q8WUX1	baseline and differential
# FUNCTION	S38A5_HUMAN	Functions as a sodium-dependent amino acid transporter which countertransport protons. Mediates the saturable, pH- sensitive, and electrogenic cotransport of several neutral amino acids including glycine, asparagine, alanine, serine, glutamine and histidine with sodium. {ECO 0000269|PubMed 11243884}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015187	glycine transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0006865	amino acid transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q8WUX1	HS
# HGNC	HGNC:18070	SLC38A5
# IntAct	Q8WUX1	8
# InterPro	IPR013057	AA_transpt_TM
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04727	GABAergic synapse
# MIM	300649	gene
# Organism	S38A5_HUMAN	Homo sapiens (Human)
# PIR	JC7626	JC7626
# Pfam	PF01490	Aa_trans
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-352230	Amino acid transport across the plasma membrane
# RecName	S38A5_HUMAN	Sodium-coupled neutral amino acid transporter 5
# RefSeq	NP_277053	NM_033518.3. [Q8WUX1-1]
# RefSeq	XP_016885450	XM_017029961.1. [Q8WUX1-1]
# SEQUENCE CAUTION	Sequence=AAL55865.1; Type=Frameshift; Positions=161, 466; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the amino acid/polyamine transporter 2 family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S38A5_HUMAN	Cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# TCDB	2.A.18.6.15	the amino acid/auxin permease (aaap) family
# TISSUE SPECIFICITY	Predominantly expressed in stomach, brain, liver, lung and intestinal tract. {ECO:0000269|PubMed	11243884}. 
# UCSC	uc033ecl	human. [Q8WUX1-1]
# eggNOG	COG0814	LUCA
# eggNOG	KOG1305	Eukaryota
BLAST	swissprot:S38A5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S38A5_HUMAN
COXPRESdb	92745	http://coxpresdb.jp/data/gene/92745.shtml
CleanEx	HS_SLC38A5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC38A5
DOI	10.1006/bbrc.2001.4504	http://dx.doi.org/10.1006/bbrc.2001.4504
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0404089101	http://dx.doi.org/10.1073/pnas.0404089101
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF196972	http://www.ebi.ac.uk/ena/data/view/AF196972
EMBL	AF276889	http://www.ebi.ac.uk/ena/data/view/AF276889
EMBL	AF318358	http://www.ebi.ac.uk/ena/data/view/AF318358
EMBL	AK094788	http://www.ebi.ac.uk/ena/data/view/AK094788
EMBL	BC019246	http://www.ebi.ac.uk/ena/data/view/BC019246
EMBL	BC027721	http://www.ebi.ac.uk/ena/data/view/BC027721
EMBL	CH471224	http://www.ebi.ac.uk/ena/data/view/CH471224
Ensembl	ENST00000595796	http://www.ensembl.org/id/ENST00000595796
Ensembl	ENST00000619100	http://www.ensembl.org/id/ENST00000619100
Ensembl	ENST00000620913	http://www.ensembl.org/id/ENST00000620913
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_function	GO:0015187	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015187
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC38A5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC38A5
GeneID	92745	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=92745
GeneTree	ENSGT00760000119147	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119147
H-InvDB	HIX0016773	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0016773
HGNC	HGNC:18070	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18070
HOGENOM	HOG000013088	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000013088&db=HOGENOM6
HOVERGEN	HBG059571	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG059571&db=HOVERGEN
HPA	HPA047411	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA047411
InParanoid	Q8WUX1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8WUX1
IntAct	Q8WUX1	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8WUX1*
InterPro	IPR013057	http://www.ebi.ac.uk/interpro/entry/IPR013057
Jabion	92745	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=92745
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:92745	http://www.genome.jp/dbget-bin/www_bget?hsa:92745
KEGG_Orthology	KO:K14992	http://www.genome.jp/dbget-bin/www_bget?KO:K14992
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
MIM	300649	http://www.ncbi.nlm.nih.gov/omim/300649
OMA	MLHMYSK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MLHMYSK
OrthoDB	EOG091G0GP8	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0GP8
PSORT	swissprot:S38A5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S38A5_HUMAN
PSORT-B	swissprot:S38A5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S38A5_HUMAN
PSORT2	swissprot:S38A5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S38A5_HUMAN
Pfam	PF01490	http://pfam.xfam.org/family/PF01490
PharmGKB	PA38289	http://www.pharmgkb.org/do/serve?objId=PA38289&objCls=Gene
Phobius	swissprot:S38A5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S38A5_HUMAN
PhylomeDB	Q8WUX1	http://phylomedb.org/?seqid=Q8WUX1
ProteinModelPortal	Q8WUX1	http://www.proteinmodelportal.org/query/uniprot/Q8WUX1
PubMed	11243884	http://www.ncbi.nlm.nih.gov/pubmed/11243884
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15498874	http://www.ncbi.nlm.nih.gov/pubmed/15498874
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
Reactome	R-HSA-352230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-352230
RefSeq	NP_277053	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_277053
RefSeq	XP_016885450	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016885450
STRING	9606.ENSP00000313740	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000313740&targetmode=cogs
TCDB	2.A.18.6.15	http://www.tcdb.org/search/result.php?tc=2.A.18.6.15
UCSC	uc033ecl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc033ecl&org=rat
UniGene	Hs.195155	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.195155
UniProtKB	S38A5_HUMAN	http://www.uniprot.org/uniprot/S38A5_HUMAN
UniProtKB-AC	Q8WUX1	http://www.uniprot.org/uniprot/Q8WUX1
charge	swissprot:S38A5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S38A5_HUMAN
eggNOG	COG0814	http://eggnogapi.embl.de/nog_data/html/tree/COG0814
eggNOG	KOG1305	http://eggnogapi.embl.de/nog_data/html/tree/KOG1305
epestfind	swissprot:S38A5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S38A5_HUMAN
garnier	swissprot:S38A5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S38A5_HUMAN
helixturnhelix	swissprot:S38A5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S38A5_HUMAN
hmoment	swissprot:S38A5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S38A5_HUMAN
iep	swissprot:S38A5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S38A5_HUMAN
inforesidue	swissprot:S38A5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S38A5_HUMAN
neXtProt	NX_Q8WUX1	http://www.nextprot.org/db/entry/NX_Q8WUX1
octanol	swissprot:S38A5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S38A5_HUMAN
pepcoil	swissprot:S38A5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S38A5_HUMAN
pepdigest	swissprot:S38A5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S38A5_HUMAN
pepinfo	swissprot:S38A5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S38A5_HUMAN
pepnet	swissprot:S38A5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S38A5_HUMAN
pepstats	swissprot:S38A5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S38A5_HUMAN
pepwheel	swissprot:S38A5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S38A5_HUMAN
pepwindow	swissprot:S38A5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S38A5_HUMAN
sigcleave	swissprot:S38A5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S38A5_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	UT2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=UT-A1; IsoId=Q15849-1; Sequence=Displayed; Name=2; Synonyms=UT-A2; IsoId=Q15849-2; Sequence=VSP_031171; 
# AltName	UT2_HUMAN	Solute carrier family 14 member 2
# AltName	UT2_HUMAN	Urea transporter, kidney
# CCDS	CCDS11924	-. [Q15849-1]
# ChiTaRS	SLC14A2	human
# DrugBank	DB03904	Urea
# Ensembl	ENST00000255226	ENSP00000255226; ENSG00000132874. [Q15849-1]
# Ensembl	ENST00000586448	ENSP00000465953; ENSG00000132874. [Q15849-1]
# ExpressionAtlas	Q15849	baseline and differential
# FUNCTION	UT2_HUMAN	Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism. {ECO 0000269|PubMed 11502588, ECO 0000269|PubMed 8647271}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_component	GO:0016324	apical plasma membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0015204	urea transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015265	urea channel activity; IBA:GO_Central.
# GO_function	GO:0050839	cell adhesion molecule binding; IDA:MGI.
# GO_process	GO:0009414	response to water deprivation; IEA:Ensembl.
# GO_process	GO:0015840	urea transport; TAS:ProtInc.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.10.3430.10	-; 2.
# Genevisible	Q15849	HS
# HGNC	HGNC:10919	SLC14A2
# INDUCTION	UT2_HUMAN	Isoform 1 is induced by low protein in the diet. Isoform 2 is induced by dehydration. 
# INTERACTION	UT2_HUMAN	O95295 SNAPIN; NbExp=5; IntAct=EBI-1633392, EBI-296723; 
# IntAct	Q15849	2
# InterPro	IPR004937	Urea_transporter
# InterPro	IPR029020	Ammonium/urea_transptr
# KEGG_Brite	ko02001	Solute carrier family
# MIM	601611	gene
# Organism	UT2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10464	PTHR10464
# PIR	S71339	S71339
# Pfam	PF03253	UT; 2
# Proteomes	UP000005640	Chromosome 18
# Reactome	R-HSA-425366	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
# RecName	UT2_HUMAN	Urea transporter 2
# RefSeq	NP_001229621	NM_001242692.1. [Q15849-1]
# RefSeq	NP_009094	NM_007163.3. [Q15849-1]
# RefSeq	XP_016881504	XM_017026015.1. [Q15849-1]
# SIMILARITY	Belongs to the urea transporter family. {ECO	0000305}.
# SUBCELLULAR LOCATION	UT2_HUMAN	Apical cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Isoform 1 interacts with SNAPIN which may be important for recruitment to the plasma membrane. {ECO:0000269|PubMed	17702749}. 
# TCDB	1.A.28.1	the urea transporter (ut) family
# TISSUE SPECIFICITY	UT2_HUMAN	Isoform 1 and isoform 2 are expressed in the inner medulla of the kidney. {ECO 0000269|PubMed 11502588, ECO 0000269|PubMed 8647271}. 
# UCSC	uc002lbe	human. [Q15849-1]
# eggNOG	COG4413	LUCA
# eggNOG	ENOG410IEWG	Eukaryota
BLAST	swissprot:UT2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:UT2_HUMAN
BioCyc	ZFISH:ENSG00000132874-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000132874-MONOMER
COXPRESdb	8170	http://coxpresdb.jp/data/gene/8170.shtml
CleanEx	HS_SLC14A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC14A2
DOI	10.1016/0014-5793(96)00425-5	http://dx.doi.org/10.1016/0014-5793(96)00425-5
DOI	10.1038/nature03983	http://dx.doi.org/10.1038/nature03983
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M705866200	http://dx.doi.org/10.1074/jbc.M705866200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB03904	http://www.drugbank.ca/drugs/DB03904
EMBL	AC023421	http://www.ebi.ac.uk/ena/data/view/AC023421
EMBL	AF349446	http://www.ebi.ac.uk/ena/data/view/AF349446
EMBL	AK292422	http://www.ebi.ac.uk/ena/data/view/AK292422
EMBL	BC110446	http://www.ebi.ac.uk/ena/data/view/BC110446
EMBL	X96969	http://www.ebi.ac.uk/ena/data/view/X96969
Ensembl	ENST00000255226	http://www.ensembl.org/id/ENST00000255226
Ensembl	ENST00000586448	http://www.ensembl.org/id/ENST00000586448
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_function	GO:0015204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015204
GO_function	GO:0015265	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015265
GO_function	GO:0050839	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050839
GO_process	GO:0009414	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009414
GO_process	GO:0015840	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015840
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.10.3430.10	http://www.cathdb.info/version/latest/superfamily/1.10.3430.10
GeneCards	SLC14A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC14A2
GeneID	8170	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8170
GeneTree	ENSGT00390000018729	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000018729
H-InvDB	HIX0014422	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0014422
HGNC	HGNC:10919	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10919
HOGENOM	HOG000168437	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000168437&db=HOGENOM6
HOVERGEN	HBG073255	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG073255&db=HOVERGEN
InParanoid	Q15849	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q15849
IntAct	Q15849	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q15849*
InterPro	IPR004937	http://www.ebi.ac.uk/interpro/entry/IPR004937
InterPro	IPR029020	http://www.ebi.ac.uk/interpro/entry/IPR029020
Jabion	8170	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=8170
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:8170	http://www.genome.jp/dbget-bin/www_bget?hsa:8170
KEGG_Orthology	KO:K08716	http://www.genome.jp/dbget-bin/www_bget?KO:K08716
MIM	601611	http://www.ncbi.nlm.nih.gov/omim/601611
OMA	EFTSPSW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EFTSPSW
OrthoDB	EOG091G095L	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G095L
PANTHER	PTHR10464	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10464
PSORT	swissprot:UT2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:UT2_HUMAN
PSORT-B	swissprot:UT2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:UT2_HUMAN
PSORT2	swissprot:UT2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:UT2_HUMAN
Pfam	PF03253	http://pfam.xfam.org/family/PF03253
PharmGKB	PA35811	http://www.pharmgkb.org/do/serve?objId=PA35811&objCls=Gene
Phobius	swissprot:UT2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:UT2_HUMAN
PhylomeDB	Q15849	http://phylomedb.org/?seqid=Q15849
ProteinModelPortal	Q15849	http://www.proteinmodelportal.org/query/uniprot/Q15849
PubMed	11502588	http://www.ncbi.nlm.nih.gov/pubmed/11502588
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16177791	http://www.ncbi.nlm.nih.gov/pubmed/16177791
PubMed	17702749	http://www.ncbi.nlm.nih.gov/pubmed/17702749
PubMed	8647271	http://www.ncbi.nlm.nih.gov/pubmed/8647271
Reactome	R-HSA-425366	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425366
RefSeq	NP_001229621	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001229621
RefSeq	NP_009094	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_009094
RefSeq	XP_016881504	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016881504
SMR	Q15849	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q15849
STRING	9606.ENSP00000255226	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000255226&targetmode=cogs
TCDB	1.A.28.1	http://www.tcdb.org/search/result.php?tc=1.A.28.1
UCSC	uc002lbe	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002lbe&org=rat
UniGene	Hs.710927	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.710927
UniProtKB	UT2_HUMAN	http://www.uniprot.org/uniprot/UT2_HUMAN
UniProtKB-AC	Q15849	http://www.uniprot.org/uniprot/Q15849
charge	swissprot:UT2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:UT2_HUMAN
eggNOG	COG4413	http://eggnogapi.embl.de/nog_data/html/tree/COG4413
eggNOG	ENOG410IEWG	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IEWG
epestfind	swissprot:UT2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:UT2_HUMAN
garnier	swissprot:UT2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:UT2_HUMAN
helixturnhelix	swissprot:UT2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:UT2_HUMAN
hmoment	swissprot:UT2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:UT2_HUMAN
iep	swissprot:UT2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:UT2_HUMAN
inforesidue	swissprot:UT2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:UT2_HUMAN
neXtProt	NX_Q15849	http://www.nextprot.org/db/entry/NX_Q15849
octanol	swissprot:UT2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:UT2_HUMAN
pepcoil	swissprot:UT2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:UT2_HUMAN
pepdigest	swissprot:UT2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:UT2_HUMAN
pepinfo	swissprot:UT2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:UT2_HUMAN
pepnet	swissprot:UT2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:UT2_HUMAN
pepstats	swissprot:UT2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:UT2_HUMAN
pepwheel	swissprot:UT2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:UT2_HUMAN
pepwindow	swissprot:UT2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:UT2_HUMAN
sigcleave	swissprot:UT2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:UT2_HUMAN
## Database	ID	URL or Descriptions
# AltName	S2611_HUMAN	Solute carrier family 26 member 11
# ChiTaRS	SLC26A11	human
# Ensembl	ENST00000361193	ENSP00000355384; ENSG00000181045
# Ensembl	ENST00000411502	ENSP00000403998; ENSG00000181045
# Ensembl	ENST00000546047	ENSP00000440724; ENSG00000181045
# Ensembl	ENST00000572725	ENSP00000459470; ENSG00000181045
# ExpressionAtlas	Q86WA9	baseline and differential
# FUNCTION	S2611_HUMAN	Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC). {ECO 0000269|PubMed 12626430}. 
# GO_component	GO:0005654	nucleoplasm; IDA:HPA.
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005783	endoplasmic reticulum; IDA:UniProtKB.
# GO_component	GO:0005794	Golgi apparatus; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IDA:UniProtKB.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005254	chloride channel activity; IBA:GO_Central.
# GO_function	GO:0008271	secondary active sulfate transmembrane transporter activity; IEA:InterPro.
# GO_function	GO:0008509	anion transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015106	bicarbonate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015116	sulfate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0019531	oxalate transmembrane transporter activity; IBA:GO_Central.
# GO_function	S2611_HUMAN	GO 0015301 anion anion antiporter activity; IBA GO_Central.
# GO_process	GO:0008272	sulfate transport; IDA:UniProtKB.
# GO_process	GO:0015701	bicarbonate transport; IBA:GO_Central.
# GO_process	GO:0042391	regulation of membrane potential; IBA:GO_Central.
# GO_process	GO:0051453	regulation of intracellular pH; IBA:GO_Central.
# GO_process	GO:1902476	chloride transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.30.750.24	-; 1.
# Genevisible	Q86WA9	HS
# HGNC	HGNC:14471	SLC26A11
# InterPro	IPR001902	SLC26A/SulP_fam
# InterPro	IPR002645	STAS_dom
# InterPro	IPR011547	SLC26A/SulP_dom
# InterPro	IPR018045	S04_transporter_CS
# KEGG_Brite	ko02001	Solute carrier family
# MIM	610117	gene
# Organism	S2611_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11814	PTHR11814
# PROSITE	PS01130	SLC26A
# PROSITE	PS50801	STAS
# Pfam	PF00916	Sulfate_transp
# Pfam	PF01740	STAS
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-427601	Multifunctional anion exchangers
# RecName	S2611_HUMAN	Sodium-independent sulfate anion transporter
# RefSeq	NP_001159819	NM_001166347.1
# RefSeq	NP_001159820	NM_001166348.1
# RefSeq	NP_001159821	NM_001166349.1
# RefSeq	NP_775897	NM_173626.3
# SIMILARITY	Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. {ECO	0000255}. 
# SIMILARITY	Contains 1 STAS domain. {ECO:0000255|PROSITE- ProRule	PRU00198}.
# SUBCELLULAR LOCATION	S2611_HUMAN	Cell membrane {ECO 0000269|PubMed 12626430}; Multi-pass membrane protein {ECO 0000269|PubMed 12626430}. Lysosome membrane; Multi-pass membrane protein {ECO 0000269|PubMed 12626430}. 
# SUPFAM	SSF52091	SSF52091
# TCDB	2.A.53.1.10	the sulfate permease (sulp) family
# TISSUE SPECIFICITY	S2611_HUMAN	Detected in all tissues tested with highest expression observed in brain, kidney, HEVEC and placenta and lowest in pancreas, skeletal muscle, liver, lung and heart. {ECO 0000269|PubMed 11087667, ECO 0000269|PubMed 12626430}. 
# UCSC	uc002jyb	human
# eggNOG	COG0659	LUCA
# eggNOG	KOG0236	Eukaryota
BLAST	swissprot:S2611_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S2611_HUMAN
COXPRESdb	284129	http://coxpresdb.jp/data/gene/284129.shtml
CleanEx	HS_SLC26A11	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC26A11
DOI	10.1002/pmic.201000196	http://dx.doi.org/10.1002/pmic.201000196
DOI	10.1006/geno.2000.6355	http://dx.doi.org/10.1006/geno.2000.6355
DOI	10.1016/j.ajhg.2012.03.012	http://dx.doi.org/10.1016/j.ajhg.2012.03.012
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/dnares/12.2.117	http://dx.doi.org/10.1093/dnares/12.2.117
DOI	10.1096/fj.02-0787fje	http://dx.doi.org/10.1096/fj.02-0787fje
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1600-0854.2007.00643.x	http://dx.doi.org/10.1111/j.1600-0854.2007.00643.x
EMBL	AF331524	http://www.ebi.ac.uk/ena/data/view/AF331524
EMBL	AF345195	http://www.ebi.ac.uk/ena/data/view/AF345195
EMBL	AJ544073	http://www.ebi.ac.uk/ena/data/view/AJ544073
EMBL	AK075248	http://www.ebi.ac.uk/ena/data/view/AK075248
EMBL	AK315132	http://www.ebi.ac.uk/ena/data/view/AK315132
EMBL	BC035900	http://www.ebi.ac.uk/ena/data/view/BC035900
EMBL	BC047451	http://www.ebi.ac.uk/ena/data/view/BC047451
Ensembl	ENST00000361193	http://www.ensembl.org/id/ENST00000361193
Ensembl	ENST00000411502	http://www.ensembl.org/id/ENST00000411502
Ensembl	ENST00000546047	http://www.ensembl.org/id/ENST00000546047
Ensembl	ENST00000572725	http://www.ensembl.org/id/ENST00000572725
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0008271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008271
GO_function	GO:0008509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008509
GO_function	GO:0015106	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015106
GO_function	GO:0015116	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015116
GO_function	GO:0015301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015301
GO_function	GO:0019531	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019531
GO_process	GO:0008272	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008272
GO_process	GO:0015701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015701
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.30.750.24	http://www.cathdb.info/version/latest/superfamily/3.30.750.24
GeneCards	SLC26A11	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC26A11
GeneID	284129	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=284129
GeneTree	ENSGT00850000132388	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00850000132388
HGNC	HGNC:14471	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14471
HOVERGEN	HBG054728	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054728&db=HOVERGEN
HPA	HPA029893	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA029893
InParanoid	Q86WA9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q86WA9
InterPro	IPR001902	http://www.ebi.ac.uk/interpro/entry/IPR001902
InterPro	IPR002645	http://www.ebi.ac.uk/interpro/entry/IPR002645
InterPro	IPR011547	http://www.ebi.ac.uk/interpro/entry/IPR011547
InterPro	IPR018045	http://www.ebi.ac.uk/interpro/entry/IPR018045
Jabion	284129	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=284129
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:284129	http://www.genome.jp/dbget-bin/www_bget?hsa:284129
KEGG_Orthology	KO:K14708	http://www.genome.jp/dbget-bin/www_bget?KO:K14708
MIM	610117	http://www.ncbi.nlm.nih.gov/omim/610117
OMA	KMDFVAG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KMDFVAG
OrthoDB	EOG091G05ML	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05ML
PANTHER	PTHR11814	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11814
PROSITE	PS01130	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01130
PROSITE	PS50801	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50801
PSORT	swissprot:S2611_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S2611_HUMAN
PSORT-B	swissprot:S2611_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S2611_HUMAN
PSORT2	swissprot:S2611_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S2611_HUMAN
Pfam	PF00916	http://pfam.xfam.org/family/PF00916
Pfam	PF01740	http://pfam.xfam.org/family/PF01740
PharmGKB	PA37888	http://www.pharmgkb.org/do/serve?objId=PA37888&objCls=Gene
Phobius	swissprot:S2611_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S2611_HUMAN
PhylomeDB	Q86WA9	http://phylomedb.org/?seqid=Q86WA9
ProteinModelPortal	Q86WA9	http://www.proteinmodelportal.org/query/uniprot/Q86WA9
PubMed	11087667	http://www.ncbi.nlm.nih.gov/pubmed/11087667
PubMed	12626430	http://www.ncbi.nlm.nih.gov/pubmed/12626430
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16303743	http://www.ncbi.nlm.nih.gov/pubmed/16303743
PubMed	17897319	http://www.ncbi.nlm.nih.gov/pubmed/17897319
PubMed	20957757	http://www.ncbi.nlm.nih.gov/pubmed/20957757
PubMed	22521418	http://www.ncbi.nlm.nih.gov/pubmed/22521418
Reactome	R-HSA-427601	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-427601
RefSeq	NP_001159819	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001159819
RefSeq	NP_001159820	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001159820
RefSeq	NP_001159821	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001159821
RefSeq	NP_775897	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_775897
SMR	Q86WA9	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q86WA9
STRING	9606.ENSP00000355384	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000355384&targetmode=cogs
SUPFAM	SSF52091	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52091
TCDB	2.A.53.1.10	http://www.tcdb.org/search/result.php?tc=2.A.53.1.10
UCSC	uc002jyb	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002jyb&org=rat
UniGene	Hs.4866	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.4866
UniProtKB	S2611_HUMAN	http://www.uniprot.org/uniprot/S2611_HUMAN
UniProtKB-AC	Q86WA9	http://www.uniprot.org/uniprot/Q86WA9
charge	swissprot:S2611_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S2611_HUMAN
eggNOG	COG0659	http://eggnogapi.embl.de/nog_data/html/tree/COG0659
eggNOG	KOG0236	http://eggnogapi.embl.de/nog_data/html/tree/KOG0236
epestfind	swissprot:S2611_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S2611_HUMAN
garnier	swissprot:S2611_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S2611_HUMAN
helixturnhelix	swissprot:S2611_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S2611_HUMAN
hmoment	swissprot:S2611_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S2611_HUMAN
iep	swissprot:S2611_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S2611_HUMAN
inforesidue	swissprot:S2611_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S2611_HUMAN
neXtProt	NX_Q86WA9	http://www.nextprot.org/db/entry/NX_Q86WA9
octanol	swissprot:S2611_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S2611_HUMAN
pepcoil	swissprot:S2611_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S2611_HUMAN
pepdigest	swissprot:S2611_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S2611_HUMAN
pepinfo	swissprot:S2611_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S2611_HUMAN
pepnet	swissprot:S2611_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S2611_HUMAN
pepstats	swissprot:S2611_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S2611_HUMAN
pepwheel	swissprot:S2611_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S2611_HUMAN
pepwindow	swissprot:S2611_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S2611_HUMAN
sigcleave	swissprot:S2611_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S2611_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNA1_HUMAN	Voltage-gated potassium channel subunit Kv1.1
# AltName	Voltage-gated K(+) channel HuKI {ECO:0000303|PubMed	19912772}
# AltName	Voltage-gated potassium channel HBK1 {ECO:0000303|PubMed	2128063}
# BioGrid	109939	7
# ChiTaRS	KCNA1	human
# DISEASE	KCNA1_HUMAN	Episodic ataxia 1 (EA1) [MIM 160120]  An autosomal dominant disorder characterized by brief episodes of ataxia and dysarthria. Neurological examination during and between the attacks demonstrates spontaneous, repetitive discharges in the distal musculature (myokymia) that arise from peripheral nerve. Nystagmus is absent. {ECO 0000269|PubMed 10355668, ECO 0000269|PubMed 11013453, ECO 0000269|PubMed 11026449, ECO 0000269|PubMed 15532032, ECO 0000269|PubMed 7842011, ECO 0000269|PubMed 8541859, ECO 0000269|PubMed 8871592, ECO 0000269|PubMed 9600245}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	KCNA1_HUMAN	Myokymia isolated 1 (MK1) [MIM 160120]  A condition characterized by spontaneous involuntary contraction of muscle fiber groups that can be observed as vermiform movement of the overlying skin. Electromyography typically shows continuous motor unit activity with spontaneous oligo- and multiplet-discharges of high intraburst frequency (myokymic discharges). Isolated spontaneous muscle twitches occur in many persons and have no grave significance. {ECO 0000269|PubMed 11026449, ECO 0000269|PubMed 17136396, ECO 0000269|PubMed 19307729}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	KCNA1_HUMAN	The cytoplasmic N-terminus is important for tetramerization and for interaction with the beta subunits that promote rapid channel closure. {ECO 0000250|UniProtKB P10499}. 
# DOMAIN	KCNA1_HUMAN	The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. {ECO 0000250|UniProtKB P63142}. 
# DrugBank	DB00228	Enflurane
# DrugBank	DB00321	Amitriptyline
# DrugBank	DB00753	Isoflurane
# DrugBank	DB01028	Methoxyflurane
# DrugBank	DB01115	Nifedipine
# DrugBank	DB01189	Desflurane
# DrugBank	DB01236	Sevoflurane
# DrugBank	DB06637	Dalfampridine
# ENZYME REGULATION	KCNA1_HUMAN	Inhibited by 1.1 mM 4-aminopyridine (4-AP) and by 20 mM tetraethylammonium (TEA), but not by charybdotoxin (CTX)(PubMed 19912772). Inhibited by dendrotoxin (DTX) (PubMed 19307729). {ECO 0000269|PubMed 19307729, ECO 0000269|PubMed 19912772}. 
# Ensembl	ENST00000382545	ENSP00000371985; ENSG00000111262
# FUNCTION	KCNA1_HUMAN	Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney (PubMed 19903818). Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability (PubMed 17156368). Forms tetrameric potassium- selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed 19912772). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed 12077175, PubMed 17156368). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels (PubMed 12077175, PubMed 17156368). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA1 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed 19912772, PubMed 19968958, PubMed 19307729, PubMed 19903818). In contrast, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed 17156368). Regulates neuronal excitability in hippocampus, especially in mossy fibers and medial perforant path axons, preventing neuronal hyperexcitability. Response to toxins that are selective for KCNA1, respectively for KCNA2, suggests that heteromeric potassium channels composed of both KCNA1 and KCNA2 play a role in pacemaking and regulate the output of deep cerebellar nuclear neurons (By similarity). May function as down- stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons (By similarity). May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) release (By similarity). Plays a role in regulating the generation of action potentials and preventing hyperexcitability in myelinated axons of the vagus nerve, and thereby contributes to the regulation of heart contraction (By similarity). Required for normal neuromuscular responses (PubMed 11026449, PubMed 17136396). Regulates the frequency of neuronal action potential firing in response to mechanical stimuli, and plays a role in the perception of pain caused by mechanical stimuli, but does not play a role in the perception of pain due to heat stimuli (By similarity). Required for normal responses to auditory stimuli and precise location of sound sources, but not for sound perception (By similarity). The use of toxins that block specific channels suggest that it contributes to the regulation of the axonal release of the neurotransmitter dopamine (By similarity). Required for normal postnatal brain development and normal proliferation of neuronal precursor cells in the brain (By similarity). Plays a role in the reabsorption of Mg(2+) in the distal convoluted tubules in the kidney and in magnesium ion homeostasis, probably via its effect on the membrane potential (PubMed 23903368, PubMed 19307729). {ECO 0000250|UniProtKB P10499, ECO 0000269|PubMed 11026449, ECO 0000269|PubMed 12077175, ECO 0000269|PubMed 15837928, ECO 0000269|PubMed 17136396, ECO 0000269|PubMed 17156368, ECO 0000269|PubMed 19307729, ECO 0000269|PubMed 19903818, ECO 0000269|PubMed 19912772, ECO 0000269|PubMed 19968958, ECO 0000269|PubMed 21106501, ECO 0000269|PubMed 23903368}. 
# GO_component	GO:0005783	endoplasmic reticulum; ISS:UniProtKB.
# GO_component	GO:0005829	cytosol; ISS:UniProtKB.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IDA:UniProtKB.
# GO_component	GO:0009986	cell surface; IEA:Ensembl.
# GO_component	GO:0016023	cytoplasmic, membrane-bounded vesicle; IEA:UniProtKB-SubCell.
# GO_component	GO:0016324	apical plasma membrane; IEA:Ensembl.
# GO_component	GO:0030054	cell junction; ISS:UniProtKB.
# GO_component	GO:0030425	dendrite; ISS:UniProtKB.
# GO_component	GO:0033270	paranode region of axon; IDA:UniProtKB.
# GO_component	GO:0042734	presynaptic membrane; ISS:UniProtKB.
# GO_component	GO:0043025	neuronal cell body; ISS:UniProtKB.
# GO_component	GO:0043204	perikaryon; IEA:UniProtKB-SubCell.
# GO_component	GO:0043679	axon terminus; ISS:UniProtKB.
# GO_component	GO:0044224	juxtaparanode region of axon; IDA:UniProtKB.
# GO_component	GO:0045202	synapse; ISS:UniProtKB.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IDA:UniProtKB.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; IDA:UniProtKB.
# GO_function	GO:0005267	potassium channel activity; TAS:ProtInc.
# GO_function	GO:0015079	potassium ion transmembrane transporter activity; TAS:ProtInc.
# GO_process	GO:0001964	startle response; IEA:Ensembl.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0006937	regulation of muscle contraction; ISS:UniProtKB.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:ProtInc.
# GO_process	GO:0007405	neuroblast proliferation; IEA:Ensembl.
# GO_process	GO:0010644	cell communication by electrical coupling; ISS:UniProtKB.
# GO_process	GO:0010960	magnesium ion homeostasis; IMP:UniProtKB.
# GO_process	GO:0019228	neuronal action potential; ISS:UniProtKB.
# GO_process	GO:0021766	hippocampus development; IEA:Ensembl.
# GO_process	GO:0023041	neuronal signal transduction; ISS:UniProtKB.
# GO_process	GO:0034613	cellular protein localization; IEA:Ensembl.
# GO_process	GO:0042391	regulation of membrane potential; IMP:UniProtKB.
# GO_process	GO:0050905	neuromuscular process; IMP:UniProtKB.
# GO_process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain; ISS:UniProtKB.
# GO_process	GO:0050976	detection of mechanical stimulus involved in sensory perception of touch; ISS:UniProtKB.
# GO_process	GO:0051260	protein homooligomerization; IEA:InterPro.
# GO_process	GO:0071286	cellular response to magnesium ion; ISS:UniProtKB.
# GO_process	GO:0071805	potassium ion transmembrane transport; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0008283	cell proliferation
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.350	-; 1.
# Genevisible	Q09470	HS
# HGNC	HGNC:6218	KCNA1
# INTERACTION	KCNA1_HUMAN	Q62936 Dlg3 (xeno); NbExp=2; IntAct=EBI-8286599, EBI-349596; P78352 DLG4; NbExp=2; IntAct=EBI-8286599, EBI-80389; 
# IntAct	Q09470	9
# InterPro	IPR000210	BTB/POZ_dom
# InterPro	IPR003131	T1-type_BTB
# InterPro	IPR003968	K_chnl_volt-dep_Kv
# InterPro	IPR003972	K_chnl_volt-dep_Kv1
# InterPro	IPR004048	K_chnl_volt-dep_Kv1.1
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR011333	SKP1/BTB/POZ
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko04040	Ion channels
# KEGG_Disease	H00749	[Nervous system disease] Episodic ataxias
# MIM	160120	phenotype
# MIM	176260	gene
# MISCELLANEOUS	The delay or D-type current observed in hippocampus pyramidal neurons is probably mediated by potassium channels containing KCNA2 plus KCNA1 or other family members. It is activated at about -50 mV, i.e. below the action potential threshold, and is characterized by slow inactivation, extremely slow recovery from inactivation, sensitivity to dendrotoxin (DTX) and to 4-aminopyridine (4-AP). {ECO:0000305|PubMed	17917103}. 
# Organism	KCNA1_HUMAN	Homo sapiens (Human)
# Orphanet	199326	Isolated autosomal dominant hypomagnesemia, Glaudemans type
# Orphanet	37612	Episodic ataxia type 1
# Orphanet	972	Hereditary continuous muscle fiber activity
# PANTHER	PTHR11537	PTHR11537
# PDB	2AFL	Model; -; A/B/C/D=326-407
# PIR	I57680	I57680
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01491	KVCHANNEL
# PRINTS	PR01496	SHAKERCHANEL
# PRINTS	PR01508	KV11CHANNEL
# PTM	KCNA1_HUMAN	N-glycosylated. {ECO 0000250|UniProtKB P10499}. 
# PTM	KCNA1_HUMAN	Palmitoylated on Cys-243; which may be required for membrane targeting. {ECO 0000269|PubMed 15837928}. 
# PTM	KCNA1_HUMAN	Phosphorylated on tyrosine residues. Phosphorylation increases in response to NRG1; this inhibits channel activity (By similarity). Phosphorylation at Ser-446 regulates channel activity by down-regulating expression at the cell membrane (PubMed 23774215). {ECO 0000250|UniProtKB P16388, ECO 0000269|PubMed 23774215}. 
# Pfam	PF00520	Ion_trans
# Pfam	PF02214	BTB_2
# Proteomes	UP000005640	Chromosome 12
# RNA EDITING	Modified_positions=400 {ECO:0000269|PubMed	12907802}; Note=Partially edited. RNA editing varies from 17% in the caudate nucleus to 68% in the spinal cord and to 77% in the medulla.; 
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# RecName	KCNA1_HUMAN	Potassium voltage-gated channel subfamily A member 1
# RefSeq	NP_000208	NM_000217.2
# SIMILARITY	Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.1/KCNA1 sub-subfamily. {ECO	0000305}.
# SMART	SM00225	BTB
# SUBCELLULAR LOCATION	KCNA1_HUMAN	Cell membrane {ECO 0000269|PubMed 12077175, ECO 0000269|PubMed 15837928, ECO 0000269|PubMed 17136396, ECO 0000269|PubMed 17156368, ECO 0000269|PubMed 19307729, ECO 0000269|PubMed 19903818, ECO 0000269|PubMed 19912772, ECO 0000269|PubMed 19968958, ECO 0000269|PubMed 23903368}; Multi- pass membrane protein {ECO 0000305}. Membrane {ECO 0000269|PubMed 11086297}. Cell projection, axon {ECO 0000269|PubMed 11086297}. Cytoplasmic vesicle {ECO 0000269|PubMed 23774215}. Perikaryon {ECO 0000250|UniProtKB P10499}. Endoplasmic reticulum {ECO 0000250|UniProtKB P10499}. Cell projection, dendrite {ECO 0000250|UniProtKB P16388}. Cell junction {ECO 0000250|UniProtKB P16388}. Cell junction, synapse {ECO 0000250|UniProtKB P16388}. Cell junction, synapse, presynaptic cell membrane {ECO 0000250|UniProtKB P10499}. Note=Homotetrameric KCNA1 is primarily located in the endoplasmic reticulum. Interaction with KCNA2 and KCNAB2 or with KCNA4 and KCNAB2 promotes expression at the cell membrane (By similarity). Detected at axon terminals (By similarity). {ECO 0000250|UniProtKB P10499, ECO 0000250|UniProtKB P16388}. 
# SUBUNIT	KCNA1_HUMAN	Homotetramer and heterotetramer with other channel- forming alpha subunits, such as KCNA2, KCNA4, KCNA5, KCNA6 and KCNA7 (PubMed 12077175, PubMed 17156368). Channel activity is regulated by interaction with the beta subunits KCNAB1 and KCNAB2 (PubMed 12077175, PubMed 17156368). Identified in a complex with KCNA2 and KCNAB2 (PubMed 11086297). Interacts (via C-terminus) with the PDZ domains of DLG1, DLG2 and DLG4 (By similarity). Interacts with LGI1 within a complex containing LGI1, KCNA4 and KCNAB1 (By similarity). Interacts (via N-terminus) with STX1A; this promotes channel inactivation (By similarity). Interacts (via N-terminus) with the heterodimer formed by GNB1 and GNG2; this promotes channel inactivation (By similarity). Can interact simultaneously with STX1A and the heterodimer formed by GNB1 and GNG2 (By similarity). Interacts (via cytoplasmic N-terminal domain) with KCNRG; this inhibits channel activity (PubMed 19968958). Interacts with ANK3; this inhibits channel activity (PubMed 23903368). {ECO 0000250|UniProtKB P10499, ECO 0000269|PubMed 11086297, ECO 0000269|PubMed 17156368, ECO 0000269|PubMed 19968958, ECO 0000269|PubMed 23903368, ECO 0000305}. 
# SUPFAM	SSF54695	SSF54695
# TCDB	1.A.1.2.12	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	KCNA1_HUMAN	Detected adjacent to nodes of Ranvier in juxtaparanodal zones in spinal cord nerve fibers, but also in paranodal regions in some myelinated spinal cord axons (at protein level) (PubMed 11086297). Detected in the islet of Langerhans (PubMed 21483673). {ECO 0000269|PubMed 11086297, ECO 0000269|PubMed 21483673}. 
# UCSC	uc001qnh	human
# eggNOG	COG1226	LUCA
# eggNOG	KOG1545	Eukaryota
BLAST	swissprot:KCNA1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNA1_HUMAN
BioCyc	ZFISH:ENSG00000111262-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000111262-MONOMER
COXPRESdb	3736	http://coxpresdb.jp/data/gene/3736.shtml
CleanEx	HS_KCNA1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNA1
DOI	10.1002/1096-9861(20000101)429:1<166::AID-CNE13>3.0.CO	http://dx.doi.org/10.1002/1096-9861(20000101)429:1<166::AID-CNE13>3.0.CO
DOI	10.1002/1098-1004(200010)16:4<374::AID-HUMU15>3.3.CO	http://dx.doi.org/10.1002/1098-1004(200010)16:4<374::AID-HUMU15>3.3.CO
DOI	10.1002/1531-8249(200010)48:4<647::AID-ANA12>3.3.CO	http://dx.doi.org/10.1002/1531-8249(200010)48:4<647::AID-ANA12>3.3.CO
DOI	10.1002/ana.410400422	http://dx.doi.org/10.1002/ana.410400422
DOI	10.1002/humu.9295	http://dx.doi.org/10.1002/humu.9295
DOI	10.1007/s004390050722	http://dx.doi.org/10.1007/s004390050722
DOI	10.1007/s10048-006-0071-z	http://dx.doi.org/10.1007/s10048-006-0071-z
DOI	10.1007/s12035-007-8001-0	http://dx.doi.org/10.1007/s12035-007-8001-0
DOI	10.1016/0896-6273(95)90022-5	http://dx.doi.org/10.1016/0896-6273(95)90022-5
DOI	10.1016/1044-7431(90)90004-N	http://dx.doi.org/10.1016/1044-7431(90)90004-N
DOI	10.1016/j.bbrc.2009.11.143	http://dx.doi.org/10.1016/j.bbrc.2009.11.143
DOI	10.1038/ki.2013.280	http://dx.doi.org/10.1038/ki.2013.280
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1038/ng1094-136	http://dx.doi.org/10.1038/ng1094-136
DOI	10.1073/pnas.0501999102	http://dx.doi.org/10.1073/pnas.0501999102
DOI	10.1074/jbc.M109.041517	http://dx.doi.org/10.1074/jbc.M109.041517
DOI	10.1093/brain/122.5.817	http://dx.doi.org/10.1093/brain/122.5.817
DOI	10.1093/brain/awq318	http://dx.doi.org/10.1093/brain/awq318
DOI	10.1093/hmg/4.9.1671	http://dx.doi.org/10.1093/hmg/4.9.1671
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1460-9568.2006.05186.x	http://dx.doi.org/10.1111/j.1460-9568.2006.05186.x
DOI	10.1126/science.1086763	http://dx.doi.org/10.1126/science.1086763
DOI	10.1158/0008-5472.CAN-12-3690	http://dx.doi.org/10.1158/0008-5472.CAN-12-3690
DOI	10.1172/JCI36948	http://dx.doi.org/10.1172/JCI36948
DOI	10.1371/journal.pone.0018213	http://dx.doi.org/10.1371/journal.pone.0018213
DrugBank	DB00228	http://www.drugbank.ca/drugs/DB00228
DrugBank	DB00321	http://www.drugbank.ca/drugs/DB00321
DrugBank	DB00753	http://www.drugbank.ca/drugs/DB00753
DrugBank	DB01028	http://www.drugbank.ca/drugs/DB01028
DrugBank	DB01115	http://www.drugbank.ca/drugs/DB01115
DrugBank	DB01189	http://www.drugbank.ca/drugs/DB01189
DrugBank	DB01236	http://www.drugbank.ca/drugs/DB01236
DrugBank	DB06637	http://www.drugbank.ca/drugs/DB06637
EMBL	AC006063	http://www.ebi.ac.uk/ena/data/view/AC006063
EMBL	BC101733	http://www.ebi.ac.uk/ena/data/view/BC101733
EMBL	BC112180	http://www.ebi.ac.uk/ena/data/view/BC112180
EMBL	CH471116	http://www.ebi.ac.uk/ena/data/view/CH471116
EMBL	L02750	http://www.ebi.ac.uk/ena/data/view/L02750
Ensembl	ENST00000382545	http://www.ensembl.org/id/ENST00000382545
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016023	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016023
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0033270	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033270
GO_component	GO:0042734	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042734
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0043204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043204
GO_component	GO:0043679	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043679
GO_component	GO:0044224	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044224
GO_component	GO:0045202	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045202
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_function	GO:0015079	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015079
GO_process	GO:0001964	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001964
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0006937	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006937
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007405	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007405
GO_process	GO:0010644	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010644
GO_process	GO:0010960	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010960
GO_process	GO:0019228	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019228
GO_process	GO:0021766	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021766
GO_process	GO:0023041	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0023041
GO_process	GO:0034613	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034613
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0050905	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050905
GO_process	GO:0050966	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050966
GO_process	GO:0050976	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050976
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:0071286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071286
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0008283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008283
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	KCNA1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNA1
GeneID	3736	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3736
GeneTree	ENSGT00760000118846	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118846
HGNC	HGNC:6218	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6218
HOGENOM	HOG000231015	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231015&db=HOGENOM6
HOVERGEN	HBG052230	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052230&db=HOVERGEN
HPA	CAB022365	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB022365
InParanoid	Q09470	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q09470
IntAct	Q09470	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q09470*
InterPro	IPR000210	http://www.ebi.ac.uk/interpro/entry/IPR000210
InterPro	IPR003131	http://www.ebi.ac.uk/interpro/entry/IPR003131
InterPro	IPR003968	http://www.ebi.ac.uk/interpro/entry/IPR003968
InterPro	IPR003972	http://www.ebi.ac.uk/interpro/entry/IPR003972
InterPro	IPR004048	http://www.ebi.ac.uk/interpro/entry/IPR004048
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR011333	http://www.ebi.ac.uk/interpro/entry/IPR011333
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	3736	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3736
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00749	http://www.genome.jp/dbget-bin/www_bget?H00749
KEGG_Gene	hsa:3736	http://www.genome.jp/dbget-bin/www_bget?hsa:3736
KEGG_Orthology	KO:K04874	http://www.genome.jp/dbget-bin/www_bget?KO:K04874
MIM	160120	http://www.ncbi.nlm.nih.gov/omim/160120
MIM	176260	http://www.ncbi.nlm.nih.gov/omim/176260
MINT	MINT-1900397	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1900397
OMA	IHRIDNT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IHRIDNT
Orphanet	199326	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=199326
Orphanet	37612	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=37612
Orphanet	972	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=972
OrthoDB	EOG091G10NU	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G10NU
PANTHER	PTHR11537	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537
PDB	2AFL	http://www.ebi.ac.uk/pdbe-srv/view/entry/2AFL
PDBsum	2AFL	http://www.ebi.ac.uk/pdbsum/2AFL
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01491	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01491
PRINTS	PR01496	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01496
PRINTS	PR01508	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01508
PSORT	swissprot:KCNA1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNA1_HUMAN
PSORT-B	swissprot:KCNA1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNA1_HUMAN
PSORT2	swissprot:KCNA1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNA1_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF02214	http://pfam.xfam.org/family/PF02214
PharmGKB	PA30019	http://www.pharmgkb.org/do/serve?objId=PA30019&objCls=Gene
Phobius	swissprot:KCNA1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNA1_HUMAN
PhylomeDB	Q09470	http://phylomedb.org/?seqid=Q09470
ProteinModelPortal	Q09470	http://www.proteinmodelportal.org/query/uniprot/Q09470
PubMed	10355668	http://www.ncbi.nlm.nih.gov/pubmed/10355668
PubMed	11013453	http://www.ncbi.nlm.nih.gov/pubmed/11013453
PubMed	11026449	http://www.ncbi.nlm.nih.gov/pubmed/11026449
PubMed	11086297	http://www.ncbi.nlm.nih.gov/pubmed/11086297
PubMed	12077175	http://www.ncbi.nlm.nih.gov/pubmed/12077175
PubMed	12907802	http://www.ncbi.nlm.nih.gov/pubmed/12907802
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15532032	http://www.ncbi.nlm.nih.gov/pubmed/15532032
PubMed	15837928	http://www.ncbi.nlm.nih.gov/pubmed/15837928
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	17136396	http://www.ncbi.nlm.nih.gov/pubmed/17136396
PubMed	17156368	http://www.ncbi.nlm.nih.gov/pubmed/17156368
PubMed	17917103	http://www.ncbi.nlm.nih.gov/pubmed/17917103
PubMed	19307729	http://www.ncbi.nlm.nih.gov/pubmed/19307729
PubMed	19903818	http://www.ncbi.nlm.nih.gov/pubmed/19903818
PubMed	19912772	http://www.ncbi.nlm.nih.gov/pubmed/19912772
PubMed	19968958	http://www.ncbi.nlm.nih.gov/pubmed/19968958
PubMed	21106501	http://www.ncbi.nlm.nih.gov/pubmed/21106501
PubMed	2128063	http://www.ncbi.nlm.nih.gov/pubmed/2128063
PubMed	21483673	http://www.ncbi.nlm.nih.gov/pubmed/21483673
PubMed	23774215	http://www.ncbi.nlm.nih.gov/pubmed/23774215
PubMed	23903368	http://www.ncbi.nlm.nih.gov/pubmed/23903368
PubMed	7842011	http://www.ncbi.nlm.nih.gov/pubmed/7842011
PubMed	8541859	http://www.ncbi.nlm.nih.gov/pubmed/8541859
PubMed	8845167	http://www.ncbi.nlm.nih.gov/pubmed/8845167
PubMed	8871592	http://www.ncbi.nlm.nih.gov/pubmed/8871592
PubMed	9600245	http://www.ncbi.nlm.nih.gov/pubmed/9600245
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
RefSeq	NP_000208	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000208
SMART	SM00225	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225
SMR	Q09470	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q09470
STRING	9606.ENSP00000371985	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000371985&targetmode=cogs
SUPFAM	SSF54695	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54695
TCDB	1.A.1.2.12	http://www.tcdb.org/search/result.php?tc=1.A.1.2.12
UCSC	uc001qnh	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001qnh&org=rat
UniGene	Hs.416139	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.416139
UniProtKB	KCNA1_HUMAN	http://www.uniprot.org/uniprot/KCNA1_HUMAN
UniProtKB-AC	Q09470	http://www.uniprot.org/uniprot/Q09470
charge	swissprot:KCNA1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNA1_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG1545	http://eggnogapi.embl.de/nog_data/html/tree/KOG1545
epestfind	swissprot:KCNA1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNA1_HUMAN
garnier	swissprot:KCNA1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNA1_HUMAN
helixturnhelix	swissprot:KCNA1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNA1_HUMAN
hmoment	swissprot:KCNA1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNA1_HUMAN
iep	swissprot:KCNA1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNA1_HUMAN
inforesidue	swissprot:KCNA1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNA1_HUMAN
neXtProt	NX_Q09470	http://www.nextprot.org/db/entry/NX_Q09470
octanol	swissprot:KCNA1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNA1_HUMAN
pepcoil	swissprot:KCNA1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNA1_HUMAN
pepdigest	swissprot:KCNA1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNA1_HUMAN
pepinfo	swissprot:KCNA1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNA1_HUMAN
pepnet	swissprot:KCNA1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNA1_HUMAN
pepstats	swissprot:KCNA1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNA1_HUMAN
pepwheel	swissprot:KCNA1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNA1_HUMAN
pepwindow	swissprot:KCNA1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNA1_HUMAN
sigcleave	swissprot:KCNA1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNA1_HUMAN
## Database	ID	URL or Descriptions
# AltName	S20A2_HUMAN	Gibbon ape leukemia virus receptor 2
# AltName	S20A2_HUMAN	Phosphate transporter 2
# AltName	S20A2_HUMAN	Solute carrier family 20 member 2
# BioGrid	112463	13
# ChiTaRS	SLC20A2	human
# DISEASE	S20A2_HUMAN	Basal ganglia calcification, idiopathic, 1 (IBGC1) [MIM 213600]  A form of basal ganglia calcification, an autosomal dominant condition characterized by symmetric calcification in the basal ganglia and other brain regions. Affected individuals can either be asymptomatic or show a wide spectrum of neuropsychiatric symptoms, including parkinsonism, dystonia, tremor, ataxia, dementia, psychosis, seizures, and chronic headache. Serum levels of calcium, phosphate, alkaline phosphatase and parathyroid hormone are normal. The neuropathological hallmark of the disease is vascular and pericapillary calcification, mainly of calcium phosphate, in the affected brain areas. {ECO 0000269|PubMed 22327515, ECO 0000269|PubMed 23334463, ECO 0000269|PubMed 23406454, ECO 0000269|PubMed 23939468, ECO 0000269|PubMed 24065723, ECO 0000269|PubMed 24463626, ECO 0000269|PubMed 25284758}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000342228	ENSP00000340465; ENSG00000168575
# Ensembl	ENST00000520179	ENSP00000429712; ENSG00000168575
# Ensembl	ENST00000520262	ENSP00000429754; ENSG00000168575
# ExpressionAtlas	Q08357	baseline and differential
# FUNCTION	S20A2_HUMAN	Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. {ECO 0000269|PubMed 11435563, ECO 0000269|PubMed 12205090, ECO 0000269|PubMed 15955065, ECO 0000269|PubMed 16790504, ECO 0000269|PubMed 8302848}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0001618	virus receptor activity; IEA:UniProtKB-KW.
# GO_function	GO:0004872	receptor activity; TAS:ProtInc.
# GO_function	GO:0005315	inorganic phosphate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015321	sodium-dependent phosphate transmembrane transporter activity; TAS:Reactome.
# GO_function	S20A2_HUMAN	GO 0005436 sodium phosphate symporter activity; TAS ProtInc.
# GO_function	S20A2_HUMAN	GO 0015319 sodium inorganic phosphate symporter activity; IBA GO_Central.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q08357	HS
# HGNC	HGNC:10947	SLC20A2
# INDUCTION	Increased by phosphate depletion in osteosarcoma cell lines. {ECO:0000269|PubMed	9151850}. 
# IntAct	Q08357	2
# InterPro	IPR001204	Phos_transporter
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H01574	[Nervous system disease] Fahr's disease
# MIM	158378	gene
# MIM	213600	phenotype
# Organism	S20A2_HUMAN	Homo sapiens (Human)
# Orphanet	1980	Bilateral striopallidodentate calcinosis
# PANTHER	PTHR11101	PTHR11101
# PIR	A37000	A37000
# Pfam	PF01384	PHO4
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-427652	Sodium-coupled phosphate cotransporters
# RecName	S20A2_HUMAN	Sodium-dependent phosphate transporter 2
# RefSeq	NP_001244109	NM_001257180.1
# RefSeq	NP_001244110	NM_001257181.1
# RefSeq	NP_006740	NM_006749.4
# RefSeq	XP_005273670	XM_005273613.3
# RefSeq	XP_016869237	XM_017013748.1
# SIMILARITY	Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S20A2_HUMAN	Cell membrane {ECO 0000269|PubMed 9151850}; Multi-pass membrane protein {ECO 0000269|PubMed 9151850}. 
# SUBUNIT	S20A2_HUMAN	Homodimer. {ECO 0000269|PubMed 12205090, ECO 0000269|PubMed 15955065}. 
# TCDB	2.A.20.2	the inorganic phosphate transporter (pit) family
# TISSUE SPECIFICITY	S20A2_HUMAN	Ubiquitously expressed. 
# UCSC	uc003xpe	human
# eggNOG	COG0306	LUCA
# eggNOG	KOG2493	Eukaryota
BLAST	swissprot:S20A2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S20A2_HUMAN
BioCyc	ZFISH:ENSG00000168575-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000168575-MONOMER
COXPRESdb	6575	http://coxpresdb.jp/data/gene/6575.shtml
CleanEx	HS_SLC20A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC20A2
DOI	10.1002/mds.26053	http://dx.doi.org/10.1002/mds.26053
DOI	10.1007/s10048-012-0349-2	http://dx.doi.org/10.1007/s10048-012-0349-2
DOI	10.1016/j.gene.2013.07.071	http://dx.doi.org/10.1016/j.gene.2013.07.071
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/ng.1077	http://dx.doi.org/10.1038/ng.1077
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.91.3.1168	http://dx.doi.org/10.1073/pnas.91.3.1168
DOI	10.1074/jbc.M207096200	http://dx.doi.org/10.1074/jbc.M207096200
DOI	10.1093/brain/awt255	http://dx.doi.org/10.1093/brain/awt255
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/ene.12044	http://dx.doi.org/10.1111/ene.12044
DOI	10.1111/j.1742-4658.2005.04720.x	http://dx.doi.org/10.1111/j.1742-4658.2005.04720.x
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1128/JVI.75.12.5584-5592.2001	http://dx.doi.org/10.1128/JVI.75.12.5584-5592.2001
DOI	10.1128/JVI.75.15.6841-6849.2001	http://dx.doi.org/10.1128/JVI.75.15.6841-6849.2001
DOI	10.1152/ajpcell.00015.2006	http://dx.doi.org/10.1152/ajpcell.00015.2006
DOI	10.1212/WNL.0000000000000143	http://dx.doi.org/10.1212/WNL.0000000000000143
EMBL	AK291202	http://www.ebi.ac.uk/ena/data/view/AK291202
EMBL	BC028600	http://www.ebi.ac.uk/ena/data/view/BC028600
EMBL	L20852	http://www.ebi.ac.uk/ena/data/view/L20852
Ensembl	ENST00000342228	http://www.ensembl.org/id/ENST00000342228
Ensembl	ENST00000520179	http://www.ensembl.org/id/ENST00000520179
Ensembl	ENST00000520262	http://www.ensembl.org/id/ENST00000520262
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0001618	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001618
GO_function	GO:0004872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004872
GO_function	GO:0005315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005315
GO_function	GO:0005436	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005436
GO_function	GO:0015319	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015319
GO_function	GO:0015321	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015321
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC20A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC20A2
GeneID	6575	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6575
GeneTree	ENSGT00390000014879	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000014879
HGNC	HGNC:10947	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10947
HOGENOM	HOG000231892	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231892&db=HOGENOM6
HOVERGEN	HBG053358	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053358&db=HOVERGEN
HPA	HPA026540	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA026540
InParanoid	Q08357	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q08357
IntAct	Q08357	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q08357*
InterPro	IPR001204	http://www.ebi.ac.uk/interpro/entry/IPR001204
Jabion	6575	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6575
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H01574	http://www.genome.jp/dbget-bin/www_bget?H01574
KEGG_Gene	hsa:6575	http://www.genome.jp/dbget-bin/www_bget?hsa:6575
KEGG_Orthology	KO:K14640	http://www.genome.jp/dbget-bin/www_bget?KO:K14640
MIM	158378	http://www.ncbi.nlm.nih.gov/omim/158378
MIM	213600	http://www.ncbi.nlm.nih.gov/omim/213600
OMA	PAQESNY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PAQESNY
Orphanet	1980	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1980
OrthoDB	EOG091G07J5	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07J5
PANTHER	PTHR11101	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11101
PSORT	swissprot:S20A2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S20A2_HUMAN
PSORT-B	swissprot:S20A2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S20A2_HUMAN
PSORT2	swissprot:S20A2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S20A2_HUMAN
Pfam	PF01384	http://pfam.xfam.org/family/PF01384
PharmGKB	PA35834	http://www.pharmgkb.org/do/serve?objId=PA35834&objCls=Gene
Phobius	swissprot:S20A2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S20A2_HUMAN
PhylomeDB	Q08357	http://phylomedb.org/?seqid=Q08357
ProteinModelPortal	Q08357	http://www.proteinmodelportal.org/query/uniprot/Q08357
PubMed	11356966	http://www.ncbi.nlm.nih.gov/pubmed/11356966
PubMed	11435563	http://www.ncbi.nlm.nih.gov/pubmed/11435563
PubMed	12205090	http://www.ncbi.nlm.nih.gov/pubmed/12205090
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15955065	http://www.ncbi.nlm.nih.gov/pubmed/15955065
PubMed	16790504	http://www.ncbi.nlm.nih.gov/pubmed/16790504
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	22327515	http://www.ncbi.nlm.nih.gov/pubmed/22327515
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	23334463	http://www.ncbi.nlm.nih.gov/pubmed/23334463
PubMed	23406454	http://www.ncbi.nlm.nih.gov/pubmed/23406454
PubMed	23939468	http://www.ncbi.nlm.nih.gov/pubmed/23939468
PubMed	24065723	http://www.ncbi.nlm.nih.gov/pubmed/24065723
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	24463626	http://www.ncbi.nlm.nih.gov/pubmed/24463626
PubMed	25284758	http://www.ncbi.nlm.nih.gov/pubmed/25284758
PubMed	8302848	http://www.ncbi.nlm.nih.gov/pubmed/8302848
PubMed	9151850	http://www.ncbi.nlm.nih.gov/pubmed/9151850
Reactome	R-HSA-427652	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-427652
RefSeq	NP_001244109	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001244109
RefSeq	NP_001244110	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001244110
RefSeq	NP_006740	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006740
RefSeq	XP_005273670	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005273670
RefSeq	XP_016869237	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016869237
STRING	9606.ENSP00000340465	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000340465&targetmode=cogs
TCDB	2.A.20.2	http://www.tcdb.org/search/result.php?tc=2.A.20.2
UCSC	uc003xpe	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003xpe&org=rat
UniGene	Hs.653173	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.653173
UniGene	Hs.654763	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.654763
UniProtKB	S20A2_HUMAN	http://www.uniprot.org/uniprot/S20A2_HUMAN
UniProtKB-AC	Q08357	http://www.uniprot.org/uniprot/Q08357
charge	swissprot:S20A2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S20A2_HUMAN
eggNOG	COG0306	http://eggnogapi.embl.de/nog_data/html/tree/COG0306
eggNOG	KOG2493	http://eggnogapi.embl.de/nog_data/html/tree/KOG2493
epestfind	swissprot:S20A2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S20A2_HUMAN
garnier	swissprot:S20A2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S20A2_HUMAN
helixturnhelix	swissprot:S20A2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S20A2_HUMAN
hmoment	swissprot:S20A2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S20A2_HUMAN
iep	swissprot:S20A2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S20A2_HUMAN
inforesidue	swissprot:S20A2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S20A2_HUMAN
neXtProt	NX_Q08357	http://www.nextprot.org/db/entry/NX_Q08357
octanol	swissprot:S20A2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S20A2_HUMAN
pepcoil	swissprot:S20A2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S20A2_HUMAN
pepdigest	swissprot:S20A2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S20A2_HUMAN
pepinfo	swissprot:S20A2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S20A2_HUMAN
pepnet	swissprot:S20A2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S20A2_HUMAN
pepstats	swissprot:S20A2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S20A2_HUMAN
pepwheel	swissprot:S20A2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S20A2_HUMAN
pepwindow	swissprot:S20A2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S20A2_HUMAN
sigcleave	swissprot:S20A2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S20A2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	VMAT1_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P54219-1; Sequence=Displayed; Name=2; Synonyms=VMAT1delta15; IsoId=P54219-2; Sequence=VSP_046305; Note=Unable to uptake serotonin.; Name=3; IsoId=P54219-3; Sequence=VSP_046304; Note=No experimental confirmation available.; 
# AltName	VMAT1_HUMAN	Solute carrier family 18 member 1
# AltName	VMAT1_HUMAN	Vesicular amine transporter 1
# BioGrid	112458	56
# CCDS	CCDS47814	-. [P54219-3]
# CCDS	CCDS47815	-. [P54219-2]
# CCDS	CCDS6013	-. [P54219-1]
# CDD	cd06174	MFS
# DrugBank	DB00206	Reserpine
# DrugBank	DB00368	Norepinephrine
# DrugBank	DB01363	Ephedra
# DrugBank	DB01577	Methamphetamine
# Ensembl	ENST00000265808	ENSP00000265808; ENSG00000036565. [P54219-3]
# Ensembl	ENST00000276373	ENSP00000276373; ENSG00000036565. [P54219-1]
# Ensembl	ENST00000381608	ENSP00000371021; ENSG00000036565. [P54219-2]
# Ensembl	ENST00000437980	ENSP00000413361; ENSG00000036565. [P54219-2]
# Ensembl	ENST00000440926	ENSP00000387549; ENSG00000036565. [P54219-1]
# Ensembl	ENST00000519026	ENSP00000429664; ENSG00000036565. [P54219-3]
# ExpressionAtlas	P54219	baseline and differential
# FUNCTION	VMAT1_HUMAN	Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells. {ECO 0000269|PubMed 16326835}. 
# GO_component	GO:0005789	endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0030672	synaptic vesicle membrane; IBA:GO_Central.
# GO_component	GO:0043195	terminal bouton; IBA:GO_Central.
# GO_component	GO:0070083	clathrin-sculpted monoamine transport vesicle membrane; TAS:Reactome.
# GO_function	GO:0008504	monoamine transmembrane transporter activity; TAS:UniProtKB.
# GO_function	GO:0015222	serotonin transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015238	drug transmembrane transporter activity; IEA:InterPro.
# GO_process	GO:0007268	chemical synaptic transmission; IBA:GO_Central.
# GO_process	GO:0015842	aminergic neurotransmitter loading into synaptic vesicle; IBA:GO_Central.
# GO_process	GO:0015844	monoamine transport; TAS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# Genevisible	P54219	HS
# HGNC	HGNC:10934	SLC18A1
# InterPro	IPR004734	Multidrug-R
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04726	Serotonergic synapse
# KEGG_Pathway	ko04728	Dopaminergic synapse
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05030	Cocaine addiction
# KEGG_Pathway	ko05031	Amphetamine addiction
# KEGG_Pathway	ko05034	Alcoholism
# MIM	193002	gene
# Organism	VMAT1_HUMAN	Homo sapiens (Human)
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-442660	Na+/Cl- dependent neurotransmitter transporters
# RecName	VMAT1_HUMAN	Chromaffin granule amine transporter
# RefSeq	NP_001129163	NM_001135691.2. [P54219-1]
# RefSeq	NP_001135796	NM_001142324.1. [P54219-3]
# RefSeq	NP_001135797	NM_001142325.1. [P54219-2]
# RefSeq	NP_003044	NM_003053.3. [P54219-1]
# RefSeq	XP_011542928	XM_011544626.1. [P54219-3]
# RefSeq	XP_011542929	XM_011544627.1. [P54219-2]
# SIMILARITY	Belongs to the major facilitator superfamily. Vesicular transporter family. {ECO	0000305}.
# SUBCELLULAR LOCATION	VMAT1_HUMAN	Isoform 1  Cytoplasmic vesicle membrane {ECO 0000269|PubMed 16326835}; Multi-pass membrane protein {ECO 0000269|PubMed 16326835}. 
# SUBCELLULAR LOCATION	VMAT1_HUMAN	Isoform 2  Endoplasmic reticulum membrane {ECO 0000269|PubMed 16326835}; Multi-pass membrane protein {ECO 0000269|PubMed 16326835}. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.1.2.12	the major facilitator superfamily (mfs)
# TIGRFAMs	TIGR00880	2_A_01_02
# UCSC	uc003wzm	human. [P54219-1]
# eggNOG	ENOG410XW69	LUCA
# eggNOG	KOG3764	Eukaryota
BLAST	swissprot:VMAT1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VMAT1_HUMAN
BioCyc	ZFISH:ENSG00000036565-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000036565-MONOMER
COXPRESdb	6570	http://coxpresdb.jp/data/gene/6570.shtml
CleanEx	HS_SLC18A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC18A1
CleanEx	HS_VAT1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_VAT1
DOI	10.1038/nature04406	http://dx.doi.org/10.1038/nature04406
DOI	10.1073/pnas.93.10.5166	http://dx.doi.org/10.1073/pnas.93.10.5166
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1677/jme.1.01875	http://dx.doi.org/10.1677/jme.1.01875
DrugBank	DB00206	http://www.drugbank.ca/drugs/DB00206
DrugBank	DB00368	http://www.drugbank.ca/drugs/DB00368
DrugBank	DB01363	http://www.drugbank.ca/drugs/DB01363
DrugBank	DB01577	http://www.drugbank.ca/drugs/DB01577
EMBL	AC025853	http://www.ebi.ac.uk/ena/data/view/AC025853
EMBL	BC006317	http://www.ebi.ac.uk/ena/data/view/BC006317
EMBL	U39905	http://www.ebi.ac.uk/ena/data/view/U39905
Ensembl	ENST00000265808	http://www.ensembl.org/id/ENST00000265808
Ensembl	ENST00000276373	http://www.ensembl.org/id/ENST00000276373
Ensembl	ENST00000381608	http://www.ensembl.org/id/ENST00000381608
Ensembl	ENST00000437980	http://www.ensembl.org/id/ENST00000437980
Ensembl	ENST00000440926	http://www.ensembl.org/id/ENST00000440926
Ensembl	ENST00000519026	http://www.ensembl.org/id/ENST00000519026
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0030672	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030672
GO_component	GO:0043195	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043195
GO_component	GO:0070083	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070083
GO_function	GO:0008504	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008504
GO_function	GO:0015222	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015222
GO_function	GO:0015238	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015238
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0015842	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015842
GO_process	GO:0015844	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015844
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GeneCards	SLC18A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC18A1
GeneID	6570	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6570
GeneTree	ENSGT00390000003851	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000003851
HGNC	HGNC:10934	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10934
HOGENOM	HOG000018545	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000018545&db=HOGENOM6
HOVERGEN	HBG055082	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG055082&db=HOVERGEN
InParanoid	P54219	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P54219
InterPro	IPR004734	http://www.ebi.ac.uk/interpro/entry/IPR004734
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	6570	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6570
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6570	http://www.genome.jp/dbget-bin/www_bget?hsa:6570
KEGG_Orthology	KO:K08155	http://www.genome.jp/dbget-bin/www_bget?KO:K08155
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04726	http://www.genome.jp/kegg-bin/show_pathway?ko04726
KEGG_Pathway	ko04728	http://www.genome.jp/kegg-bin/show_pathway?ko04728
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05030	http://www.genome.jp/kegg-bin/show_pathway?ko05030
KEGG_Pathway	ko05031	http://www.genome.jp/kegg-bin/show_pathway?ko05031
KEGG_Pathway	ko05034	http://www.genome.jp/kegg-bin/show_pathway?ko05034
MIM	193002	http://www.ncbi.nlm.nih.gov/omim/193002
OMA	NNCLQGT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NNCLQGT
OrthoDB	EOG091G0534	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0534
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:VMAT1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VMAT1_HUMAN
PSORT-B	swissprot:VMAT1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VMAT1_HUMAN
PSORT2	swissprot:VMAT1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VMAT1_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA324	http://www.pharmgkb.org/do/serve?objId=PA324&objCls=Gene
Phobius	swissprot:VMAT1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VMAT1_HUMAN
PhylomeDB	P54219	http://phylomedb.org/?seqid=P54219
ProteinModelPortal	P54219	http://www.proteinmodelportal.org/query/uniprot/P54219
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16326835	http://www.ncbi.nlm.nih.gov/pubmed/16326835
PubMed	16421571	http://www.ncbi.nlm.nih.gov/pubmed/16421571
PubMed	8643547	http://www.ncbi.nlm.nih.gov/pubmed/8643547
Reactome	R-HSA-442660	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442660
RefSeq	NP_001129163	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001129163
RefSeq	NP_001135796	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001135796
RefSeq	NP_001135797	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001135797
RefSeq	NP_003044	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003044
RefSeq	XP_011542928	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011542928
RefSeq	XP_011542929	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011542929
STRING	9606.ENSP00000276373	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000276373&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.2.12	http://www.tcdb.org/search/result.php?tc=2.A.1.2.12
TIGRFAMs	TIGR00880	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00880
UCSC	uc003wzm	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003wzm&org=rat
UniGene	Hs.158322	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.158322
UniProtKB	VMAT1_HUMAN	http://www.uniprot.org/uniprot/VMAT1_HUMAN
UniProtKB-AC	P54219	http://www.uniprot.org/uniprot/P54219
charge	swissprot:VMAT1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VMAT1_HUMAN
eggNOG	ENOG410XW69	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XW69
eggNOG	KOG3764	http://eggnogapi.embl.de/nog_data/html/tree/KOG3764
epestfind	swissprot:VMAT1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VMAT1_HUMAN
garnier	swissprot:VMAT1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VMAT1_HUMAN
helixturnhelix	swissprot:VMAT1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VMAT1_HUMAN
hmoment	swissprot:VMAT1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VMAT1_HUMAN
iep	swissprot:VMAT1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VMAT1_HUMAN
inforesidue	swissprot:VMAT1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VMAT1_HUMAN
neXtProt	NX_P54219	http://www.nextprot.org/db/entry/NX_P54219
octanol	swissprot:VMAT1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VMAT1_HUMAN
pepcoil	swissprot:VMAT1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VMAT1_HUMAN
pepdigest	swissprot:VMAT1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VMAT1_HUMAN
pepinfo	swissprot:VMAT1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VMAT1_HUMAN
pepnet	swissprot:VMAT1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VMAT1_HUMAN
pepstats	swissprot:VMAT1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VMAT1_HUMAN
pepwheel	swissprot:VMAT1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VMAT1_HUMAN
pepwindow	swissprot:VMAT1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VMAT1_HUMAN
sigcleave	swissprot:VMAT1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VMAT1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AP2B1_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P63010-1; Sequence=Displayed; Name=2; IsoId=P63010-2; Sequence=VSP_011490; Name=3; Synonyms=Ap2beta-NY; IsoId=P63010-3; Sequence=VSP_047805; Note=Highly expressed in the testis, spleen, thymus, prostate, ovary, blood leukocyte and brain, but not in the heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. Testis expression is restricted to germ cells and is about 3-fold higher in adults than in embryos.; 
# AltName	AP2B1_HUMAN	AP105B
# AltName	AP2B1_HUMAN	Adaptor protein complex AP-2 subunit beta
# AltName	AP2B1_HUMAN	Adaptor-related protein complex 2 subunit beta
# AltName	AP2B1_HUMAN	Beta-2-adaptin
# AltName	AP2B1_HUMAN	Beta-adaptin
# AltName	AP2B1_HUMAN	Clathrin assembly protein complex 2 beta large chain
# AltName	AP2B1_HUMAN	Plasma membrane adaptor HA2/AP2 adaptin beta subunit
# BioGrid	106672	110
# CCDS	CCDS32621	-. [P63010-2]
# CCDS	CCDS32622	-. [P63010-1]
# ChiTaRS	AP2B1	human
# Ensembl	ENST00000610402	ENSP00000483185; ENSG00000006125. [P63010-2]
# Ensembl	ENST00000618940	ENSP00000482835; ENSG00000006125. [P63010-2]
# Ensembl	ENST00000621914	ENSP00000482315; ENSG00000006125. [P63010-1]
# ExpressionAtlas	P63010	baseline and differential
# FUNCTION	AP2B1_HUMAN	Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin- associated sorting proteins (CLASPs) are recognized by their [DE]- X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly. {ECO 0000269|PubMed 14745134, ECO 0000269|PubMed 14985334, ECO 0000269|PubMed 15473838, ECO 0000269|PubMed 19033387}. 
# GO_component	GO:0005802	trans-Golgi network; IEA:Ensembl.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0030122	AP-2 adaptor complex; TAS:BHF-UCL.
# GO_component	GO:0030666	endocytic vesicle membrane; TAS:Reactome.
# GO_component	GO:0030669	clathrin-coated endocytic vesicle membrane; TAS:Reactome.
# GO_component	GO:0036020	endolysosome membrane; TAS:Reactome.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_function	GO:0005048	signal sequence binding; TAS:BHF-UCL.
# GO_function	GO:0008565	protein transporter activity; IEA:InterPro.
# GO_function	GO:0030276	clathrin binding; IPI:UniProtKB.
# GO_process	GO:0003281	ventricular septum development; IEA:Ensembl.
# GO_process	GO:0006886	intracellular protein transport; IEA:InterPro.
# GO_process	GO:0007018	microtubule-based movement; TAS:Reactome.
# GO_process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
# GO_process	GO:0035904	aorta development; IEA:Ensembl.
# GO_process	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0048013	ephrin receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0048268	clathrin coat assembly; IEA:Ensembl.
# GO_process	GO:0050690	regulation of defense response to virus by virus; TAS:Reactome.
# GO_process	GO:0060071	Wnt signaling pathway, planar cell polarity pathway; TAS:Reactome.
# GO_process	GO:0060976	coronary vasculature development; IEA:Ensembl.
# GO_process	GO:0072583	clathrin-dependent endocytosis; TAS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0048856	anatomical structure development
# Gene3D	1.25.10.10	-; 1.
# Gene3D	2.60.40.1150	-; 1.
# Gene3D	3.30.310.10	-; 1.
# Genevisible	P63010	HS
# HGNC	HGNC:563	AP2B1
# INTERACTION	AP2B1_HUMAN	Q9UHB7 AFF4; NbExp=3; IntAct=EBI-432924, EBI-395282; Q9UHB7-2 AFF4; NbExp=3; IntAct=EBI-432924, EBI-10261324; Q9Y6Q5 AP1M2; NbExp=4; IntAct=EBI-432924, EBI-752250; P84092 Ap2m1 (xeno); NbExp=2; IntAct=EBI-432924, EBI-297693; Q6NVW7 KPNA2; NbExp=3; IntAct=EBI-432924, EBI-9377406; Q5SW96 LDLRAP1; NbExp=4; IntAct=EBI-432924, EBI-747813; Q16626 MEA1; NbExp=2; IntAct=EBI-432924, EBI-744921; P40692 MLH1; NbExp=4; IntAct=EBI-11529439, EBI-744248; Q8WWR8-2 NEU4; NbExp=3; IntAct=EBI-432924, EBI-10277551; P12236 SLC25A6; NbExp=3; IntAct=EBI-432924, EBI-356254; Q9NVV9 THAP1; NbExp=4; IntAct=EBI-432924, EBI-741515; Q99757 TXN2; NbExp=3; IntAct=EBI-432924, EBI-2932492; Q01081 U2AF1; NbExp=3; IntAct=EBI-432924, EBI-632461; Q8N4L5 XRCC6BP1; NbExp=3; IntAct=EBI-432924, EBI-10265517; 
# IntAct	P63010	90
# InterPro	IPR000225	Armadillo
# InterPro	IPR002553	Clathrin/coatomer_adapt-like_N
# InterPro	IPR008152	Clathrin_a/b/g-adaptin_app_Ig
# InterPro	IPR009028	Coatomer/calthrin_app_sub_C
# InterPro	IPR011989	ARM-like
# InterPro	IPR012295	Beta2_adaptin/TBP_C_dom
# InterPro	IPR013037	Clathrin_b-adaptin_app_Ig-like
# InterPro	IPR013041	Coatomer/clathrin_app_Ig-like
# InterPro	IPR015151	B-adaptin_app_sub_C
# InterPro	IPR016024	ARM-type_fold
# InterPro	IPR016342	AP_complex_bsu_1_2_4
# InterPro	IPR026739	AP_beta
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Pathway	ko04144	Endocytosis
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04961	Endocrine and other factor-regulated calcium reabsorption
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	601025	gene
# Organism	AP2B1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11134	PTHR11134
# PDB	1E42	X-ray; 1.70 A; A/B=701-937
# PDB	2G30	X-ray; 1.60 A; A=701-937
# PDB	2IV8	X-ray; 2.80 A; A=700-937
# PDB	2IV9	X-ray; 1.90 A; A/B=700-937
# PDB	2JKR	X-ray; 2.98 A; B/E=1-591
# PDB	2JKT	X-ray; 3.40 A; B/E=1-591
# PDB	2VGL	X-ray; 2.59 A; B=1-591
# PDB	2XA7	X-ray; 3.10 A; B=1-592
# PDB	4UQI	X-ray; 2.79 A; B=1-651
# PIR	A35553	A35553
# PIRSF	PIRSF002291	AP_complex_beta
# PTM	AP2B1_HUMAN	Phosphorylation at Tyr-737 by SRC occurs at the plasma membrane in clathrin-coated vesicles (CCVs). {ECO 0000269|PubMed 17456551, ECO 0000269|PubMed 18938240}. 
# Pfam	PF01602	Adaptin_N
# Pfam	PF02883	Alpha_adaptinC2
# Pfam	PF09066	B2-adapt-app_C
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-167590	Nef Mediated CD4 Down-regulation
# Reactome	R-HSA-171052	LDL-mediated lipid transport
# Reactome	R-HSA-177504	Retrograde neurotrophin signalling
# Reactome	R-HSA-182218	Nef Mediated CD8 Down-regulation
# Reactome	R-HSA-2132295	MHC class II antigen presentation
# Reactome	R-HSA-3928665	EPH-ephrin mediated repulsion of cells
# Reactome	R-HSA-416993	Trafficking of GluR2-containing AMPA receptors
# Reactome	R-HSA-437239	Recycling pathway of L1
# Reactome	R-HSA-5099900	WNT5A-dependent internalization of FZD4
# Reactome	R-HSA-5140745	WNT5A-dependent internalization of FZD2, FZD5 and ROR2
# Reactome	R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis
# Reactome	R-HSA-8856828	Clathrin-mediated endocytosis
# Reactome	R-HSA-8866427	VLDLR internalisation and degradation
# RecName	AP2B1_HUMAN	AP-2 complex subunit beta
# RefSeq	NP_001025177	NM_001030006.1. [P63010-2]
# RefSeq	NP_001273	NM_001282.2. [P63010-1]
# RefSeq	XP_005257994	XM_005257937.3. [P63010-2]
# RefSeq	XP_005257995	XM_005257938.2. [P63010-2]
# RefSeq	XP_011522757	XM_011524455.2. [P63010-3]
# RefSeq	XP_016879773	XM_017024284.1. [P63010-1]
# RefSeq	XP_016879775	XM_017024286.1. [P63010-3]
# SIMILARITY	Belongs to the adaptor complexes large subunit family. {ECO	0000305}.
# SMART	SM00185	ARM; 2
# SMART	SM00809	Alpha_adaptinC2
# SMART	SM01020	B2-adapt-app_C
# SUBCELLULAR LOCATION	AP2B1_HUMAN	Cell membrane {ECO 0000269|PubMed 14530274}. Membrane, coated pit {ECO 0000269|PubMed 14530274}; Peripheral membrane protein {ECO 0000269|PubMed 14530274}; Cytoplasmic side {ECO 0000269|PubMed 14530274}. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. 
# SUBUNIT	AP2B1_HUMAN	Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1). Interacts with EPN1. Interacts with EPS15; clathrin competes with EPS15. Interacts with SNAP91; clathrin competes with SNAP91. Interacts with CLTC; clathrin competes with EPS15, SNAP91 and PIP5K1C. Interacts with LDLRAP1. Interacts with AMPH and BIN1. Interacts with ARF6 (GDP-bound). Interacts (dephosphorylated at Tyr-737) with ARRB1; phosphorylation of AP2B1 at Tyr-737 disrupts the interaction. Interacts with SLC2A8. Interacts with SCYL1 and SCYL2. Interacts with TGFBR1 and TGFBR2. Interacts with PIP5K1C; clathrin competes with PIP5K1C (By similarity). Interacts with DENND1B, but not with DENND1A, nor DENND1C. Interacts with FCHO1. {ECO 0000250, ECO 0000269|PubMed 10944104, ECO 0000269|PubMed 11777907, ECO 0000269|PubMed 12086608, ECO 0000269|PubMed 12429842, ECO 0000269|PubMed 15728179, ECO 0000269|PubMed 16516836, ECO 0000269|PubMed 16723738, ECO 0000269|PubMed 16903783, ECO 0000269|PubMed 17456551, ECO 0000269|PubMed 17719203, ECO 0000269|PubMed 19140243, ECO 0000269|PubMed 20154091, ECO 0000269|PubMed 22484487}. 
# SUPFAM	SSF48371	SSF48371
# SUPFAM	SSF49348	SSF49348
# SUPFAM	SSF55711	SSF55711
# UCSC	uc002hjq	human. [P63010-1]
# eggNOG	COG5096	LUCA
# eggNOG	KOG1061	Eukaryota
BLAST	swissprot:AP2B1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AP2B1_HUMAN
BioCyc	ZFISH:ENSG00000006125-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000006125-MONOMER
COXPRESdb	163	http://coxpresdb.jp/data/gene/163.shtml
CleanEx	HS_AP2B1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AP2B1
DIP	DIP-33098N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-33098N
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/S0092-8674(02)00735-3	http://dx.doi.org/10.1016/S0092-8674(02)00735-3
DOI	10.1016/j.cellsig.2007.07.015	http://dx.doi.org/10.1016/j.cellsig.2007.07.015
DOI	10.1016/j.cellsig.2008.09.013	http://dx.doi.org/10.1016/j.cellsig.2008.09.013
DOI	10.1016/j.devcel.2006.01.016	http://dx.doi.org/10.1016/j.devcel.2006.01.016
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1038/nature07422	http://dx.doi.org/10.1038/nature07422
DOI	10.1038/ncb2473	http://dx.doi.org/10.1038/ncb2473
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1074/jbc.C300390200	http://dx.doi.org/10.1074/jbc.C300390200
DOI	10.1074/jbc.C400046200	http://dx.doi.org/10.1074/jbc.C400046200
DOI	10.1074/jbc.M108490200	http://dx.doi.org/10.1074/jbc.M108490200
DOI	10.1074/jbc.M109.050930	http://dx.doi.org/10.1074/jbc.M109.050930
DOI	10.1074/jbc.M501029200	http://dx.doi.org/10.1074/jbc.M501029200
DOI	10.1091/mbc.02-07-0104	http://dx.doi.org/10.1091/mbc.02-07-0104
DOI	10.1093/emboj/19.16.4216	http://dx.doi.org/10.1093/emboj/19.16.4216
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1745-7262.2005.00025.x	http://dx.doi.org/10.1111/j.1745-7262.2005.00025.x
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1146/annurev.cellbio.20.010403.104543	http://dx.doi.org/10.1146/annurev.cellbio.20.010403.104543
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1242/jcs.02943	http://dx.doi.org/10.1242/jcs.02943
DOI	10.1242/jcs.033522	http://dx.doi.org/10.1242/jcs.033522
DOI	10.1242/jcs.03444	http://dx.doi.org/10.1242/jcs.03444
DOI	10.1247/csf.28.419	http://dx.doi.org/10.1247/csf.28.419
DOI	10.1371/journal.pbio.0040262	http://dx.doi.org/10.1371/journal.pbio.0040262
EMBL	AC004134	http://www.ebi.ac.uk/ena/data/view/AC004134
EMBL	AC006237	http://www.ebi.ac.uk/ena/data/view/AC006237
EMBL	AC015911	http://www.ebi.ac.uk/ena/data/view/AC015911
EMBL	AY341427	http://www.ebi.ac.uk/ena/data/view/AY341427
EMBL	BC006201	http://www.ebi.ac.uk/ena/data/view/BC006201
EMBL	CH471147	http://www.ebi.ac.uk/ena/data/view/CH471147
EMBL	CH471147	http://www.ebi.ac.uk/ena/data/view/CH471147
EMBL	M34175	http://www.ebi.ac.uk/ena/data/view/M34175
Ensembl	ENST00000610402	http://www.ensembl.org/id/ENST00000610402
Ensembl	ENST00000618940	http://www.ensembl.org/id/ENST00000618940
Ensembl	ENST00000621914	http://www.ensembl.org/id/ENST00000621914
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005802	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005802
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0030122	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030122
GO_component	GO:0030666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030666
GO_component	GO:0030669	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030669
GO_component	GO:0036020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036020
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0005048	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005048
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0030276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030276
GO_process	GO:0003281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003281
GO_process	GO:0006886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006886
GO_process	GO:0007018	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007018
GO_process	GO:0019886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019886
GO_process	GO:0035904	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035904
GO_process	GO:0042059	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042059
GO_process	GO:0048013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048013
GO_process	GO:0048268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048268
GO_process	GO:0050690	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050690
GO_process	GO:0060071	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060071
GO_process	GO:0060976	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060976
GO_process	GO:0072583	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072583
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
Gene3D	2.60.40.1150	http://www.cathdb.info/version/latest/superfamily/2.60.40.1150
Gene3D	3.30.310.10	http://www.cathdb.info/version/latest/superfamily/3.30.310.10
GeneCards	AP2B1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=AP2B1
GeneID	163	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=163
GeneTree	ENSGT00530000063138	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063138
HGNC	HGNC:563	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:563
HOGENOM	HOG000163270	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000163270&db=HOGENOM6
HOVERGEN	HBG050515	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050515&db=HOVERGEN
HPA	CAB017631	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB017631
HPA	HPA056733	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA056733
InParanoid	P63010	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P63010
IntAct	P63010	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P63010*
InterPro	IPR000225	http://www.ebi.ac.uk/interpro/entry/IPR000225
InterPro	IPR002553	http://www.ebi.ac.uk/interpro/entry/IPR002553
InterPro	IPR008152	http://www.ebi.ac.uk/interpro/entry/IPR008152
InterPro	IPR009028	http://www.ebi.ac.uk/interpro/entry/IPR009028
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR012295	http://www.ebi.ac.uk/interpro/entry/IPR012295
InterPro	IPR013037	http://www.ebi.ac.uk/interpro/entry/IPR013037
InterPro	IPR013041	http://www.ebi.ac.uk/interpro/entry/IPR013041
InterPro	IPR015151	http://www.ebi.ac.uk/interpro/entry/IPR015151
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
InterPro	IPR016342	http://www.ebi.ac.uk/interpro/entry/IPR016342
InterPro	IPR026739	http://www.ebi.ac.uk/interpro/entry/IPR026739
Jabion	163	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=163
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Gene	hsa:163	http://www.genome.jp/dbget-bin/www_bget?hsa:163
KEGG_Orthology	KO:K11825	http://www.genome.jp/dbget-bin/www_bget?KO:K11825
KEGG_Pathway	ko04144	http://www.genome.jp/kegg-bin/show_pathway?ko04144
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04961	http://www.genome.jp/kegg-bin/show_pathway?ko04961
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	601025	http://www.ncbi.nlm.nih.gov/omim/601025
MINT	MINT-256705	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-256705
OMA	CHLNADA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CHLNADA
OrthoDB	EOG091G019U	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G019U
PANTHER	PTHR11134	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11134
PDB	1E42	http://www.ebi.ac.uk/pdbe-srv/view/entry/1E42
PDB	2G30	http://www.ebi.ac.uk/pdbe-srv/view/entry/2G30
PDB	2IV8	http://www.ebi.ac.uk/pdbe-srv/view/entry/2IV8
PDB	2IV9	http://www.ebi.ac.uk/pdbe-srv/view/entry/2IV9
PDB	2JKR	http://www.ebi.ac.uk/pdbe-srv/view/entry/2JKR
PDB	2JKT	http://www.ebi.ac.uk/pdbe-srv/view/entry/2JKT
PDB	2VGL	http://www.ebi.ac.uk/pdbe-srv/view/entry/2VGL
PDB	2XA7	http://www.ebi.ac.uk/pdbe-srv/view/entry/2XA7
PDB	4UQI	http://www.ebi.ac.uk/pdbe-srv/view/entry/4UQI
PDBsum	1E42	http://www.ebi.ac.uk/pdbsum/1E42
PDBsum	2G30	http://www.ebi.ac.uk/pdbsum/2G30
PDBsum	2IV8	http://www.ebi.ac.uk/pdbsum/2IV8
PDBsum	2IV9	http://www.ebi.ac.uk/pdbsum/2IV9
PDBsum	2JKR	http://www.ebi.ac.uk/pdbsum/2JKR
PDBsum	2JKT	http://www.ebi.ac.uk/pdbsum/2JKT
PDBsum	2VGL	http://www.ebi.ac.uk/pdbsum/2VGL
PDBsum	2XA7	http://www.ebi.ac.uk/pdbsum/2XA7
PDBsum	4UQI	http://www.ebi.ac.uk/pdbsum/4UQI
PSORT	swissprot:AP2B1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AP2B1_HUMAN
PSORT-B	swissprot:AP2B1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AP2B1_HUMAN
PSORT2	swissprot:AP2B1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AP2B1_HUMAN
Pfam	PF01602	http://pfam.xfam.org/family/PF01602
Pfam	PF02883	http://pfam.xfam.org/family/PF02883
Pfam	PF09066	http://pfam.xfam.org/family/PF09066
PharmGKB	PA24854	http://www.pharmgkb.org/do/serve?objId=PA24854&objCls=Gene
Phobius	swissprot:AP2B1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AP2B1_HUMAN
PhylomeDB	P63010	http://phylomedb.org/?seqid=P63010
ProteinModelPortal	P63010	http://www.proteinmodelportal.org/query/uniprot/P63010
PubMed	10944104	http://www.ncbi.nlm.nih.gov/pubmed/10944104
PubMed	11777907	http://www.ncbi.nlm.nih.gov/pubmed/11777907
PubMed	12086608	http://www.ncbi.nlm.nih.gov/pubmed/12086608
PubMed	12429842	http://www.ncbi.nlm.nih.gov/pubmed/12429842
PubMed	14530274	http://www.ncbi.nlm.nih.gov/pubmed/14530274
PubMed	14745134	http://www.ncbi.nlm.nih.gov/pubmed/14745134
PubMed	14985334	http://www.ncbi.nlm.nih.gov/pubmed/14985334
PubMed	15473838	http://www.ncbi.nlm.nih.gov/pubmed/15473838
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15728179	http://www.ncbi.nlm.nih.gov/pubmed/15728179
PubMed	15897975	http://www.ncbi.nlm.nih.gov/pubmed/15897975
PubMed	16516836	http://www.ncbi.nlm.nih.gov/pubmed/16516836
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	16723738	http://www.ncbi.nlm.nih.gov/pubmed/16723738
PubMed	16903783	http://www.ncbi.nlm.nih.gov/pubmed/16903783
PubMed	17456551	http://www.ncbi.nlm.nih.gov/pubmed/17456551
PubMed	17719203	http://www.ncbi.nlm.nih.gov/pubmed/17719203
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	18938240	http://www.ncbi.nlm.nih.gov/pubmed/18938240
PubMed	19033387	http://www.ncbi.nlm.nih.gov/pubmed/19033387
PubMed	19140243	http://www.ncbi.nlm.nih.gov/pubmed/19140243
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	1969413	http://www.ncbi.nlm.nih.gov/pubmed/1969413
PubMed	20154091	http://www.ncbi.nlm.nih.gov/pubmed/20154091
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22484487	http://www.ncbi.nlm.nih.gov/pubmed/22484487
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-167590	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-167590
Reactome	R-HSA-171052	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-171052
Reactome	R-HSA-177504	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-177504
Reactome	R-HSA-182218	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-182218
Reactome	R-HSA-2132295	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2132295
Reactome	R-HSA-3928665	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3928665
Reactome	R-HSA-416993	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-416993
Reactome	R-HSA-437239	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-437239
Reactome	R-HSA-5099900	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5099900
Reactome	R-HSA-5140745	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5140745
Reactome	R-HSA-8856825	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8856825
Reactome	R-HSA-8856828	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8856828
Reactome	R-HSA-8866427	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8866427
RefSeq	NP_001025177	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001025177
RefSeq	NP_001273	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273
RefSeq	XP_005257994	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005257994
RefSeq	XP_005257995	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005257995
RefSeq	XP_011522757	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011522757
RefSeq	XP_016879773	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016879773
RefSeq	XP_016879775	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016879775
SMART	SM00185	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00185
SMART	SM00809	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00809
SMART	SM01020	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01020
SMR	P63010	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P63010
STRING	9606.ENSP00000314414	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000314414&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
SUPFAM	SSF49348	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49348
SUPFAM	SSF55711	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55711
UCSC	uc002hjq	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002hjq&org=rat
UniGene	Hs.514819	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.514819
UniProtKB	AP2B1_HUMAN	http://www.uniprot.org/uniprot/AP2B1_HUMAN
UniProtKB-AC	P63010	http://www.uniprot.org/uniprot/P63010
charge	swissprot:AP2B1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AP2B1_HUMAN
eggNOG	COG5096	http://eggnogapi.embl.de/nog_data/html/tree/COG5096
eggNOG	KOG1061	http://eggnogapi.embl.de/nog_data/html/tree/KOG1061
epestfind	swissprot:AP2B1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AP2B1_HUMAN
garnier	swissprot:AP2B1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AP2B1_HUMAN
helixturnhelix	swissprot:AP2B1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AP2B1_HUMAN
hmoment	swissprot:AP2B1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AP2B1_HUMAN
iep	swissprot:AP2B1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AP2B1_HUMAN
inforesidue	swissprot:AP2B1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AP2B1_HUMAN
neXtProt	NX_P63010	http://www.nextprot.org/db/entry/NX_P63010
octanol	swissprot:AP2B1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AP2B1_HUMAN
pepcoil	swissprot:AP2B1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AP2B1_HUMAN
pepdigest	swissprot:AP2B1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AP2B1_HUMAN
pepinfo	swissprot:AP2B1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AP2B1_HUMAN
pepnet	swissprot:AP2B1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AP2B1_HUMAN
pepstats	swissprot:AP2B1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AP2B1_HUMAN
pepwheel	swissprot:AP2B1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AP2B1_HUMAN
pepwindow	swissprot:AP2B1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AP2B1_HUMAN
sigcleave	swissprot:AP2B1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AP2B1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S17A4_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9Y2C5-1; Sequence=Displayed; Name=2; IsoId=Q9Y2C5-2; Sequence=VSP_031178; Name=3; IsoId=Q9Y2C5-3; Sequence=VSP_054938; Note=No experimental confirmation available.; Name=4; IsoId=Q9Y2C5-4; Sequence=VSP_031178, VSP_054939, VSP_054940, VSP_054941; Note=No experimental confirmation available.; 
# AltName	S17A4_HUMAN	Solute carrier family 17 member 4
# CCDS	CCDS4564	-. [Q9Y2C5-1]
# CCDS	CCDS75411	-. [Q9Y2C5-2]
# CDD	cd06174	MFS
# Ensembl	ENST00000377905	ENSP00000367137; ENSG00000146039. [Q9Y2C5-1]
# Ensembl	ENST00000397076	ENSP00000380266; ENSG00000146039. [Q9Y2C5-4]
# Ensembl	ENST00000439485	ENSP00000391345; ENSG00000146039. [Q9Y2C5-2]
# ExpressionAtlas	Q9Y2C5	baseline and differential
# FUNCTION	S17A4_HUMAN	Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions. May be involved in urate extrusion from the intestinal duct. May recognize hydrophilic anionic drugs such as aspirin, salicylate, and ibuprofen as substrates. Able to actively transport inorganic phosphate into cells via Na(+) cotransport (in vitro). {ECO 0000269|PubMed 22460716}. 
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0016324	apical plasma membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0015321	sodium-dependent phosphate transmembrane transporter activity; IBA:GO_Central.
# GO_function	S17A4_HUMAN	GO 0005436 sodium phosphate symporter activity; TAS ProtInc.
# GO_process	GO:0006796	phosphate-containing compound metabolic process; TAS:ProtInc.
# GO_process	GO:0006814	sodium ion transport; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q9Y2C5	HS
# HGNC	HGNC:10932	SLC17A4
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	604216	gene
# Organism	S17A4_HUMAN	Homo sapiens (Human)
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 6
# RecName	S17A4_HUMAN	Probable small intestine urate exporter
# RefSeq	NP_001273050	NM_001286121.1. [Q9Y2C5-2]
# RefSeq	NP_005486	NM_005495.2. [Q9Y2C5-1]
# RefSeq	XP_011512513	XM_011514211.1. [Q9Y2C5-2]
# RefSeq	XP_011512521	XM_011514219.2. [Q9Y2C5-3]
# SIMILARITY	Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S17A4_HUMAN	Apical cell membrane {ECO 0000269|PubMed 22460716}; Multi-pass membrane protein {ECO 0000269|PubMed 22460716}. Cell membrane {ECO 0000269|PubMed 22460716}; Multi-pass membrane protein {ECO 0000269|PubMed 22460716}. Note=Apical in the intestinal brush border. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.1.14.24	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	S17A4_HUMAN	Abundantly expressed in pancreas, liver, colon and small intestine, less in kidney. Not detected in the adrenal glands, brain, placenta, heart, testis, skeletal muscle, and lungs. {ECO 0000269|PubMed 10319585, ECO 0000269|PubMed 22460716}. 
# UCSC	uc003nfe	human. [Q9Y2C5-1]
# eggNOG	ENOG410XPWC	LUCA
# eggNOG	KOG2532	Eukaryota
BLAST	swissprot:S17A4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S17A4_HUMAN
BioCyc	ZFISH:ENSG00000146039-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000146039-MONOMER
COXPRESdb	10050	http://coxpresdb.jp/data/gene/10050.shtml
CleanEx	HS_SLC17A4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC17A4
DOI	10.1007/s100380050140	http://dx.doi.org/10.1007/s100380050140
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1152/ajpcell.00015.2012	http://dx.doi.org/10.1152/ajpcell.00015.2012
EMBL	AB020527	http://www.ebi.ac.uk/ena/data/view/AB020527
EMBL	AK293354	http://www.ebi.ac.uk/ena/data/view/AK293354
EMBL	AL391194	http://www.ebi.ac.uk/ena/data/view/AL391194
EMBL	BC109207	http://www.ebi.ac.uk/ena/data/view/BC109207
EMBL	BC109208	http://www.ebi.ac.uk/ena/data/view/BC109208
EMBL	CH471087	http://www.ebi.ac.uk/ena/data/view/CH471087
Ensembl	ENST00000377905	http://www.ensembl.org/id/ENST00000377905
Ensembl	ENST00000397076	http://www.ensembl.org/id/ENST00000397076
Ensembl	ENST00000439485	http://www.ensembl.org/id/ENST00000439485
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_function	GO:0005436	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005436
GO_function	GO:0015321	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015321
GO_process	GO:0006796	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006796
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	SLC17A4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC17A4
GeneID	10050	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10050
GeneTree	ENSGT00760000119079	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119079
HGNC	HGNC:10932	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10932
HOGENOM	HOG000169313	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000169313&db=HOGENOM6
HOVERGEN	HBG008834	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG008834&db=HOVERGEN
HPA	HPA030179	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA030179
InParanoid	Q9Y2C5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y2C5
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	10050	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10050
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:10050	http://www.genome.jp/dbget-bin/www_bget?hsa:10050
KEGG_Orthology	KO:K12300	http://www.genome.jp/dbget-bin/www_bget?KO:K12300
MIM	604216	http://www.ncbi.nlm.nih.gov/omim/604216
OMA	ILQLCNF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ILQLCNF
OrthoDB	EOG091G080B	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G080B
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:S17A4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S17A4_HUMAN
PSORT-B	swissprot:S17A4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S17A4_HUMAN
PSORT2	swissprot:S17A4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S17A4_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA35823	http://www.pharmgkb.org/do/serve?objId=PA35823&objCls=Gene
Phobius	swissprot:S17A4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S17A4_HUMAN
PhylomeDB	Q9Y2C5	http://phylomedb.org/?seqid=Q9Y2C5
ProteinModelPortal	Q9Y2C5	http://www.proteinmodelportal.org/query/uniprot/Q9Y2C5
PubMed	10319585	http://www.ncbi.nlm.nih.gov/pubmed/10319585
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	22460716	http://www.ncbi.nlm.nih.gov/pubmed/22460716
RefSeq	NP_001273050	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273050
RefSeq	NP_005486	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005486
RefSeq	XP_011512513	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011512513
RefSeq	XP_011512521	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011512521
STRING	9606.ENSP00000367137	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000367137&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.14.24	http://www.tcdb.org/search/result.php?tc=2.A.1.14.24
UCSC	uc003nfe	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003nfe&org=rat
UniGene	Hs.282931	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.282931
UniProtKB	S17A4_HUMAN	http://www.uniprot.org/uniprot/S17A4_HUMAN
UniProtKB-AC	Q9Y2C5	http://www.uniprot.org/uniprot/Q9Y2C5
charge	swissprot:S17A4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S17A4_HUMAN
eggNOG	ENOG410XPWC	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPWC
eggNOG	KOG2532	http://eggnogapi.embl.de/nog_data/html/tree/KOG2532
epestfind	swissprot:S17A4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S17A4_HUMAN
garnier	swissprot:S17A4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S17A4_HUMAN
helixturnhelix	swissprot:S17A4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S17A4_HUMAN
hmoment	swissprot:S17A4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S17A4_HUMAN
iep	swissprot:S17A4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S17A4_HUMAN
inforesidue	swissprot:S17A4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S17A4_HUMAN
neXtProt	NX_Q9Y2C5	http://www.nextprot.org/db/entry/NX_Q9Y2C5
octanol	swissprot:S17A4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S17A4_HUMAN
pepcoil	swissprot:S17A4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S17A4_HUMAN
pepdigest	swissprot:S17A4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S17A4_HUMAN
pepinfo	swissprot:S17A4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S17A4_HUMAN
pepnet	swissprot:S17A4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S17A4_HUMAN
pepstats	swissprot:S17A4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S17A4_HUMAN
pepwheel	swissprot:S17A4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S17A4_HUMAN
pepwindow	swissprot:S17A4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S17A4_HUMAN
sigcleave	swissprot:S17A4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S17A4_HUMAN
## Database	ID	URL or Descriptions
# AltName	S6A12_HUMAN	BGT-1
# AltName	S6A12_HUMAN	Na(+)/Cl(-) betaine/GABA transporter
# AltName	S6A12_HUMAN	Solute carrier family 6 member 12
# BioGrid	112430	2
# Ensembl	ENST00000359674	ENSP00000352702; ENSG00000111181
# Ensembl	ENST00000397296	ENSP00000380464; ENSG00000111181
# Ensembl	ENST00000424061	ENSP00000399136; ENSG00000111181
# Ensembl	ENST00000536824	ENSP00000444268; ENSG00000111181
# ExpressionAtlas	P48065	baseline and differential
# FUNCTION	S6A12_HUMAN	Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_component	GO:0043005	neuron projection; IBA:GO_Central.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; TAS:Reactome.
# GO_function	S6A12_HUMAN	GO 0005328 neurotransmitter sodium symporter activity; IEA InterPro.
# GO_function	S6A12_HUMAN	GO 0005332 gamma-aminobutyric acid sodium symporter activity; IBA GO_Central.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006836	neurotransmitter transport; IBA:GO_Central.
# GO_process	GO:0006865	amino acid transport; TAS:Reactome.
# GO_process	GO:0007268	chemical synaptic transmission; IBA:GO_Central.
# GO_process	GO:0015812	gamma-aminobutyric acid transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# Genevisible	P48065	HS
# HGNC	HGNC:11045	SLC6A12
# INTERACTION	S6A12_HUMAN	Q04864 REL; NbExp=3; IntAct=EBI-3843589, EBI-307352; 
# IntAct	P48065	2
# InterPro	IPR000175	Na/ntran_symport
# InterPro	IPR002983	Na/ntran_symport_betaine
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Brite	ko04040	 Ion channels
# MIM	603080	gene
# Organism	S6A12_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11616	PTHR11616
# PIR	S68236	S68236
# PRINTS	PR00176	NANEUSMPORT
# PRINTS	PR01198	BETTRANSPORT
# PROSITE	PS00610	NA_NEUROTRAN_SYMP_1
# PROSITE	PS00754	NA_NEUROTRAN_SYMP_2
# PROSITE	PS50267	NA_NEUROTRAN_SYMP_3
# Pfam	PF00209	SNF
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-352230	Amino acid transport across the plasma membrane
# Reactome	R-HSA-442660	Na+/Cl- dependent neurotransmitter transporters
# Reactome	R-HSA-71288	Creatine metabolism
# Reactome	R-HSA-888593	Reuptake of GABA
# RecName	S6A12_HUMAN	Sodium- and chloride-dependent betaine transporter
# RefSeq	NP_001116319	NM_001122847.2
# RefSeq	NP_001116320	NM_001122848.2
# RefSeq	NP_001193860	NM_001206931.1
# RefSeq	NP_003035	NM_003044.4
# RefSeq	XP_011519312	XM_011521010.1
# SIMILARITY	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	S6A12_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Interacts with LIN7C. {ECO	0000250}. 
# TCDB	2.A.22.3:the neurotransmitter	sodium symporter (nss) family
# TISSUE SPECIFICITY	S6A12_HUMAN	Liver, heart, skeletal muscle, placenta, and a widespread distribution in the brain. 
# UCSC	uc001qhz	human
# eggNOG	COG0733	LUCA
# eggNOG	KOG3659	Eukaryota
BLAST	swissprot:S6A12_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S6A12_HUMAN
BioCyc	ZFISH:ENSG00000111181-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000111181-MONOMER
COXPRESdb	6539	http://coxpresdb.jp/data/gene/6539.shtml
CleanEx	HS_SLC6A12	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC6A12
DOI	10.1016/0014-5793(95)01052-G	http://dx.doi.org/10.1016/0014-5793(95)01052-G
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC007406	http://www.ebi.ac.uk/ena/data/view/AC007406
EMBL	AK313690	http://www.ebi.ac.uk/ena/data/view/AK313690
EMBL	BC126215	http://www.ebi.ac.uk/ena/data/view/BC126215
EMBL	BC126217	http://www.ebi.ac.uk/ena/data/view/BC126217
EMBL	CH471116	http://www.ebi.ac.uk/ena/data/view/CH471116
EMBL	CH471116	http://www.ebi.ac.uk/ena/data/view/CH471116
EMBL	CH471116	http://www.ebi.ac.uk/ena/data/view/CH471116
EMBL	CH471116	http://www.ebi.ac.uk/ena/data/view/CH471116
EMBL	L42300	http://www.ebi.ac.uk/ena/data/view/L42300
EMBL	U27699	http://www.ebi.ac.uk/ena/data/view/U27699
Ensembl	ENST00000359674	http://www.ensembl.org/id/ENST00000359674
Ensembl	ENST00000397296	http://www.ensembl.org/id/ENST00000397296
Ensembl	ENST00000424061	http://www.ensembl.org/id/ENST00000424061
Ensembl	ENST00000536824	http://www.ensembl.org/id/ENST00000536824
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0043005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043005
GO_function	GO:0005328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005328
GO_function	GO:0005332	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005332
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006836	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006836
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0015812	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015812
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GeneCards	SLC6A12	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC6A12
GeneID	6539	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6539
GeneTree	ENSGT00760000118857	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118857
H-InvDB	HIX0037041	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0037041
H-InvDB	HIX0201858	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0201858
HGNC	HGNC:11045	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11045
HOGENOM	HOG000116406	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116406&db=HOGENOM6
HOVERGEN	HBG071421	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG071421&db=HOVERGEN
HPA	HPA034973	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA034973
InParanoid	P48065	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P48065
IntAct	P48065	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P48065*
InterPro	IPR000175	http://www.ebi.ac.uk/interpro/entry/IPR000175
InterPro	IPR002983	http://www.ebi.ac.uk/interpro/entry/IPR002983
Jabion	6539	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6539
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:6539	http://www.genome.jp/dbget-bin/www_bget?hsa:6539
KEGG_Orthology	KO:K05039	http://www.genome.jp/dbget-bin/www_bget?KO:K05039
MIM	603080	http://www.ncbi.nlm.nih.gov/omim/603080
OMA	NFTSPVM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NFTSPVM
OrthoDB	EOG091G08PX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08PX
PANTHER	PTHR11616	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11616
PRINTS	PR00176	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00176
PRINTS	PR01198	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01198
PROSITE	PS00610	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00610
PROSITE	PS00754	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00754
PROSITE	PS50267	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50267
PSORT	swissprot:S6A12_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S6A12_HUMAN
PSORT-B	swissprot:S6A12_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S6A12_HUMAN
PSORT2	swissprot:S6A12_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S6A12_HUMAN
Pfam	PF00209	http://pfam.xfam.org/family/PF00209
PharmGKB	PA35908	http://www.pharmgkb.org/do/serve?objId=PA35908&objCls=Gene
Phobius	swissprot:S6A12_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S6A12_HUMAN
PhylomeDB	P48065	http://phylomedb.org/?seqid=P48065
ProteinModelPortal	P48065	http://www.proteinmodelportal.org/query/uniprot/P48065
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	7589472	http://www.ncbi.nlm.nih.gov/pubmed/7589472
PubMed	7861179	http://www.ncbi.nlm.nih.gov/pubmed/7861179
Reactome	R-HSA-352230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-352230
Reactome	R-HSA-442660	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442660
Reactome	R-HSA-71288	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-71288
Reactome	R-HSA-888593	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-888593
RefSeq	NP_001116319	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001116319
RefSeq	NP_001116320	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001116320
RefSeq	NP_001193860	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001193860
RefSeq	NP_003035	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003035
RefSeq	XP_011519312	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011519312
SMR	P48065	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P48065
STRING	9606.ENSP00000352702	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000352702&targetmode=cogs
TCDB	2.A.22.3	http://www.tcdb.org/search/result.php?tc=2.A.22.3
UCSC	uc001qhz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001qhz&org=rat
UniGene	Hs.437174	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.437174
UniGene	Hs.737267	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.737267
UniProtKB	S6A12_HUMAN	http://www.uniprot.org/uniprot/S6A12_HUMAN
UniProtKB-AC	P48065	http://www.uniprot.org/uniprot/P48065
charge	swissprot:S6A12_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S6A12_HUMAN
eggNOG	COG0733	http://eggnogapi.embl.de/nog_data/html/tree/COG0733
eggNOG	KOG3659	http://eggnogapi.embl.de/nog_data/html/tree/KOG3659
epestfind	swissprot:S6A12_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S6A12_HUMAN
garnier	swissprot:S6A12_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S6A12_HUMAN
helixturnhelix	swissprot:S6A12_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S6A12_HUMAN
hmoment	swissprot:S6A12_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S6A12_HUMAN
iep	swissprot:S6A12_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S6A12_HUMAN
inforesidue	swissprot:S6A12_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S6A12_HUMAN
neXtProt	NX_P48065	http://www.nextprot.org/db/entry/NX_P48065
octanol	swissprot:S6A12_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S6A12_HUMAN
pepcoil	swissprot:S6A12_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S6A12_HUMAN
pepdigest	swissprot:S6A12_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S6A12_HUMAN
pepinfo	swissprot:S6A12_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S6A12_HUMAN
pepnet	swissprot:S6A12_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S6A12_HUMAN
pepstats	swissprot:S6A12_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S6A12_HUMAN
pepwheel	swissprot:S6A12_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S6A12_HUMAN
pepwindow	swissprot:S6A12_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S6A12_HUMAN
sigcleave	swissprot:S6A12_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S6A12_HUMAN
## Database	ID	URL or Descriptions
# AltName	SC6A5_HUMAN	Solute carrier family 6 member 5
# BioGrid	114599	12
# DISEASE	SC6A5_HUMAN	Hyperekplexia 3 (HKPX3) [MIM 614618]  A neurologic disorder characterized by neonatal hypertonia, an exaggerated startle response to tactile or acoustic stimuli, and life- threatening neonatal apnea episodes. Notably, in some cases, symptoms resolved in the first year of life. {ECO 0000269|PubMed 16751771}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00145	Glycine
# Ensembl	ENST00000525748	ENSP00000434364; ENSG00000165970
# ExpressionAtlas	Q9Y345	baseline and differential
# FUNCTION	SC6A5_HUMAN	Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses. {ECO 0000269|PubMed 10381548, ECO 0000269|PubMed 10606742, ECO 0000269|PubMed 9845349}. 
# GO_component	GO:0005886	plasma membrane; IDA:FlyBase.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_function	SC6A5_HUMAN	GO 0005328 neurotransmitter sodium symporter activity; IEA InterPro.
# GO_function	SC6A5_HUMAN	GO 0015375 glycine sodium symporter activity; IDA FlyBase.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:ProtInc.
# GO_process	GO:0036233	glycine import; IDA:FlyBase.
# GO_process	GO:0060012	synaptic transmission, glycinergic; IMP:FlyBase.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# Genevisible	Q9Y345	HS
# HGNC	HGNC:11051	SLC6A5
# InterPro	IPR000175	Na/ntran_symport
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00769	[Nervous system disease] Hyperekplexia
# MIM	604159	gene
# MIM	614618	phenotype
# Organism	SC6A5_HUMAN	Homo sapiens (Human)
# Orphanet	3197	Hereditary hyperekplexia
# PANTHER	PTHR11616	PTHR11616; 2
# PRINTS	PR00176	NANEUSMPORT
# PROSITE	PS00610	NA_NEUROTRAN_SYMP_1
# PROSITE	PS00754	NA_NEUROTRAN_SYMP_2
# PROSITE	PS50267	NA_NEUROTRAN_SYMP_3
# Pfam	PF00209	SNF
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-442660	Na+/Cl- dependent neurotransmitter transporters
# RecName	SC6A5_HUMAN	Sodium- and chloride-dependent glycine transporter 2
# RefSeq	NP_001305298	NM_001318369.1
# RefSeq	NP_004202	NM_004211.4
# SIMILARITY	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A5 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	SC6A5_HUMAN	Cell membrane {ECO 0000269|PubMed 10381548, ECO 0000269|PubMed 10606742, ECO 0000269|PubMed 9845349}; Multi- pass membrane protein {ECO 0000250|UniProtKB Q7K4Y6}. 
# TCDB	2.A.22.2.10:the neurotransmitter	sodium symporter (nss) family
# TISSUE SPECIFICITY	SC6A5_HUMAN	Expressed in medulla, and to a lesser extent in spinal cord and cerebellum. 
# UCSC	uc001mqd	human
# eggNOG	COG0733	LUCA
# eggNOG	KOG3659	Eukaryota
BLAST	swissprot:SC6A5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SC6A5_HUMAN
BioCyc	ZFISH:ENSG00000165970-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000165970-MONOMER
COXPRESdb	9152	http://coxpresdb.jp/data/gene/9152.shtml
CleanEx	HS_NET1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_NET1
CleanEx	HS_SLC6A5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC6A5
DOI	10.1016/S0014-5793(98)01390-8	http://dx.doi.org/10.1016/S0014-5793(98)01390-8
DOI	10.1016/S0014-5793(99)01636-1	http://dx.doi.org/10.1016/S0014-5793(99)01636-1
DOI	10.1016/S0169-328X(99)00135-7	http://dx.doi.org/10.1016/S0169-328X(99)00135-7
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1038/ng1814	http://dx.doi.org/10.1038/ng1814
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DrugBank	DB00145	http://www.drugbank.ca/drugs/DB00145
EMBL	AC090707	http://www.ebi.ac.uk/ena/data/view/AC090707
EMBL	AF085412	http://www.ebi.ac.uk/ena/data/view/AF085412
EMBL	AF117999	http://www.ebi.ac.uk/ena/data/view/AF117999
EMBL	AF142501	http://www.ebi.ac.uk/ena/data/view/AF142501
EMBL	AF352733	http://www.ebi.ac.uk/ena/data/view/AF352733
EMBL	BC096319	http://www.ebi.ac.uk/ena/data/view/BC096319
Ensembl	ENST00000525748	http://www.ensembl.org/id/ENST00000525748
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005328
GO_function	GO:0015375	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015375
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0036233	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036233
GO_process	GO:0060012	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060012
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GeneCards	SLC6A5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC6A5
GeneID	9152	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9152
GeneTree	ENSGT00760000118857	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118857
H-InvDB	HIX0035860	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0035860
HGNC	HGNC:11051	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11051
HOGENOM	HOG000116406	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116406&db=HOGENOM6
HOVERGEN	HBG071421	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG071421&db=HOVERGEN
InParanoid	Q9Y345	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y345
InterPro	IPR000175	http://www.ebi.ac.uk/interpro/entry/IPR000175
Jabion	9152	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9152
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00769	http://www.genome.jp/dbget-bin/www_bget?H00769
KEGG_Gene	hsa:9152	http://www.genome.jp/dbget-bin/www_bget?hsa:9152
KEGG_Orthology	KO:K05038	http://www.genome.jp/dbget-bin/www_bget?KO:K05038
MIM	604159	http://www.ncbi.nlm.nih.gov/omim/604159
MIM	614618	http://www.ncbi.nlm.nih.gov/omim/614618
OMA	GNALHCK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GNALHCK
Orphanet	3197	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=3197
OrthoDB	EOG091G08PX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08PX
PANTHER	PTHR11616	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11616
PRINTS	PR00176	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00176
PROSITE	PS00610	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00610
PROSITE	PS00754	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00754
PROSITE	PS50267	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50267
PSORT	swissprot:SC6A5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SC6A5_HUMAN
PSORT-B	swissprot:SC6A5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SC6A5_HUMAN
PSORT2	swissprot:SC6A5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SC6A5_HUMAN
Pfam	PF00209	http://pfam.xfam.org/family/PF00209
PharmGKB	PA35911	http://www.pharmgkb.org/do/serve?objId=PA35911&objCls=Gene
Phobius	swissprot:SC6A5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SC6A5_HUMAN
PhylomeDB	Q9Y345	http://phylomedb.org/?seqid=Q9Y345
ProteinModelPortal	Q9Y345	http://www.proteinmodelportal.org/query/uniprot/Q9Y345
PubMed	10381548	http://www.ncbi.nlm.nih.gov/pubmed/10381548
PubMed	10606742	http://www.ncbi.nlm.nih.gov/pubmed/10606742
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	16751771	http://www.ncbi.nlm.nih.gov/pubmed/16751771
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	9845349	http://www.ncbi.nlm.nih.gov/pubmed/9845349
Reactome	R-HSA-442660	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442660
RefSeq	NP_001305298	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001305298
RefSeq	NP_004202	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004202
STRING	9606.ENSP00000434364	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000434364&targetmode=cogs
TCDB	2.A.22.2.10	http://www.tcdb.org/search/result.php?tc=2.A.22.2.10
UCSC	uc001mqd	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001mqd&org=rat
UniGene	Hs.136557	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.136557
UniProtKB	SC6A5_HUMAN	http://www.uniprot.org/uniprot/SC6A5_HUMAN
UniProtKB-AC	Q9Y345	http://www.uniprot.org/uniprot/Q9Y345
charge	swissprot:SC6A5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SC6A5_HUMAN
eggNOG	COG0733	http://eggnogapi.embl.de/nog_data/html/tree/COG0733
eggNOG	KOG3659	http://eggnogapi.embl.de/nog_data/html/tree/KOG3659
epestfind	swissprot:SC6A5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SC6A5_HUMAN
garnier	swissprot:SC6A5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SC6A5_HUMAN
helixturnhelix	swissprot:SC6A5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SC6A5_HUMAN
hmoment	swissprot:SC6A5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SC6A5_HUMAN
iep	swissprot:SC6A5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SC6A5_HUMAN
inforesidue	swissprot:SC6A5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SC6A5_HUMAN
neXtProt	NX_Q9Y345	http://www.nextprot.org/db/entry/NX_Q9Y345
octanol	swissprot:SC6A5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SC6A5_HUMAN
pepcoil	swissprot:SC6A5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SC6A5_HUMAN
pepdigest	swissprot:SC6A5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SC6A5_HUMAN
pepinfo	swissprot:SC6A5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SC6A5_HUMAN
pepnet	swissprot:SC6A5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SC6A5_HUMAN
pepstats	swissprot:SC6A5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SC6A5_HUMAN
pepwheel	swissprot:SC6A5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SC6A5_HUMAN
pepwindow	swissprot:SC6A5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SC6A5_HUMAN
sigcleave	swissprot:SC6A5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SC6A5_HUMAN
## Database	ID	URL or Descriptions
# AltName	S26A3_HUMAN	Down-regulated in adenoma
# AltName	S26A3_HUMAN	Solute carrier family 26 member 3
# DEVELOPMENTAL STAGE	S26A3_HUMAN	Expression is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon. 
# DISEASE	S26A3_HUMAN	Diarrhea 1, secretory chloride, congenital (DIAR1) [MIM 214700]  A disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature. {ECO 0000269|PubMed 11524734, ECO 0000269|PubMed 19861545, ECO 0000269|PubMed 21150650, ECO 0000269|PubMed 21394828, ECO 0000269|PubMed 8896562, ECO 0000269|PubMed 9554749, ECO 0000269|PubMed 9718329}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000340010	ENSP00000345873; ENSG00000091138
# ExpressionAtlas	P40879	baseline and differential
# FUNCTION	S26A3_HUMAN	Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016020	membrane; ISS:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0031526	brush border membrane; IEA:Ensembl.
# GO_component	GO:0097225	sperm midpiece; ISS:UniProtKB.
# GO_function	GO:0003700	transcription factor activity, sequence-specific DNA binding; TAS:ProtInc.
# GO_function	GO:0003712	transcription cofactor activity; TAS:ProtInc.
# GO_function	GO:0005215	transporter activity; TAS:ProtInc.
# GO_function	GO:0005254	chloride channel activity; IBA:GO_Central.
# GO_function	GO:0005452	inorganic anion exchanger activity; TAS:Reactome.
# GO_function	GO:0008271	secondary active sulfate transmembrane transporter activity; IEA:InterPro.
# GO_function	GO:0015106	bicarbonate transmembrane transporter activity; ISS:UniProtKB.
# GO_function	GO:0015108	chloride transmembrane transporter activity; ISS:UniProtKB.
# GO_function	GO:0015116	sulfate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0019531	oxalate transmembrane transporter activity; IBA:GO_Central.
# GO_function	S26A3_HUMAN	GO 0015301 anion anion antiporter activity; IBA GO_Central.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006820	anion transport; TAS:ProtInc.
# GO_process	GO:0007588	excretion; TAS:ProtInc.
# GO_process	GO:0015701	bicarbonate transport; IBA:GO_Central.
# GO_process	GO:0042391	regulation of membrane potential; IBA:GO_Central.
# GO_process	GO:0048240	sperm capacitation; ISS:UniProtKB.
# GO_process	GO:0051453	regulation of intracellular pH; IBA:GO_Central.
# GO_process	GO:0051454	intracellular pH elevation; ISS:UniProtKB.
# GO_process	GO:0060081	membrane hyperpolarization; ISS:UniProtKB.
# GO_process	GO:0071320	cellular response to cAMP; ISS:UniProtKB.
# GO_process	GO:1902476	chloride transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0000988	transcription factor activity, protein binding
# GOslim_function	GO:0001071	nucleic acid binding transcription factor activity
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0021700	developmental maturation
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.30.750.24	-; 2.
# Genevisible	P40879	HS
# HGNC	HGNC:3018	SLC26A3
# INTERACTION	S26A3_HUMAN	Q15599 SLC9A3R2; NbExp=5; IntAct=EBI-8542350, EBI-1149760; 
# IntAct	P40879	2
# InterPro	IPR001902	SLC26A/SulP_fam
# InterPro	IPR002645	STAS_dom
# InterPro	IPR011547	SLC26A/SulP_dom
# InterPro	IPR018045	S04_transporter_CS
# InterPro	IPR030321	SLC26A3
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H01174	[Gastrointestinal disease] Congenital tufting enteropathy (DIAR5)
# KEGG_Pathway	ko04972	Pancreatic secretion
# KEGG_Pathway	ko04978	Mineral absorption
# MIM	126650	gene
# MIM	214700	phenotype
# Organism	S26A3_HUMAN	Homo sapiens (Human)
# Orphanet	53689	Congenital chloride diarrhea
# PANTHER	PTHR11814	PTHR11814; 2
# PANTHER	PTHR11814:SF19	PTHR11814:SF19; 2
# PIR	A47456	A47456
# PROSITE	PS01130	SLC26A
# PROSITE	PS50801	STAS
# PTM	S26A3_HUMAN	N-glycosylation is required for efficient cell surface expression, and protection from proteolytic degradation. {ECO 0000269|PubMed 22159084}. 
# Pfam	PF00916	Sulfate_transp
# Pfam	PF01740	STAS
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-427601	Multifunctional anion exchangers
# RecName	S26A3_HUMAN	Chloride anion exchanger
# RefSeq	NP_000102	NM_000111.2
# RefSeq	XP_011514169	XM_011515867.2
# SIMILARITY	Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. {ECO	0000305}. 
# SIMILARITY	Contains 1 STAS domain. {ECO:0000255|PROSITE- ProRule	PRU00198}.
# SUBCELLULAR LOCATION	S26A3_HUMAN	Apical cell membrane {ECO 0000269|PubMed 22159084}; Multi-pass membrane protein {ECO 0000269|PubMed 22159084}. Membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Note=Localized in sperm membranes. Midpiece of sperm tail. Colocalizes with CFTR at the midpiece of sperm tail (By similarity). {ECO 0000250}. 
# SUBUNIT	Interacts with CFTR, SLC26A6 and SLC9A3R1 (By similarity). Interacts with PDZK1. {ECO:0000250, ECO	0000269|PubMed:15766278}. 
# SUPFAM	SSF52091	SSF52091; 2
# TCDB	2.A.53.2.18	the sulfate permease (sulp) family
# TIGRFAMs	TIGR00815	sulP
# UCSC	uc003ver	human
# eggNOG	COG0659	LUCA
# eggNOG	KOG0236	Eukaryota
BLAST	swissprot:S26A3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S26A3_HUMAN
BioCyc	ZFISH:ENSG00000091138-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000091138-MONOMER
COXPRESdb	1811	http://coxpresdb.jp/data/gene/1811.shtml
CleanEx	HS_SLC26A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC26A3
DOI	10.1002/(SICI)1098-1004(1998)11:4<321::AID-HUMU10>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1998)11:4<321::AID-HUMU10>3.0.CO
DOI	10.1002/humu.1179	http://dx.doi.org/10.1002/humu.1179
DOI	10.1002/humu.21498	http://dx.doi.org/10.1002/humu.21498
DOI	10.1016/0968-0004(94)90168-6	http://dx.doi.org/10.1016/0968-0004(94)90168-6
DOI	10.1021/bi048828b	http://dx.doi.org/10.1021/bi048828b
DOI	10.1038/ng1196-316	http://dx.doi.org/10.1038/ng1196-316
DOI	10.1073/pnas.0910672106	http://dx.doi.org/10.1073/pnas.0910672106
DOI	10.1073/pnas.90.9.4166	http://dx.doi.org/10.1073/pnas.90.9.4166
DOI	10.1086/301998	http://dx.doi.org/10.1086/301998
DOI	10.1097/MPG.0b013e3181f28d1a	http://dx.doi.org/10.1097/MPG.0b013e3181f28d1a
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1152/ajpcell.00165.2011	http://dx.doi.org/10.1152/ajpcell.00165.2011
EMBL	BC025671	http://www.ebi.ac.uk/ena/data/view/BC025671
EMBL	L02785	http://www.ebi.ac.uk/ena/data/view/L02785
Ensembl	ENST00000340010	http://www.ensembl.org/id/ENST00000340010
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0031526	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031526
GO_component	GO:0097225	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097225
GO_function	GO:0003700	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700
GO_function	GO:0003712	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003712
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0005452	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005452
GO_function	GO:0008271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008271
GO_function	GO:0015106	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015106
GO_function	GO:0015108	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015108
GO_function	GO:0015116	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015116
GO_function	GO:0015301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015301
GO_function	GO:0019531	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019531
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006820	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006820
GO_process	GO:0007588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007588
GO_process	GO:0015701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015701
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0048240	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048240
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GO_process	GO:0051454	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051454
GO_process	GO:0060081	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060081
GO_process	GO:0071320	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071320
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0000988	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000988
GOslim_function	GO:0001071	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0021700	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021700
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.30.750.24	http://www.cathdb.info/version/latest/superfamily/3.30.750.24
GeneCards	SLC26A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC26A3
GeneID	1811	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1811
GeneTree	ENSGT00760000119026	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119026
HGNC	HGNC:3018	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:3018
HOGENOM	HOG000006546	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006546&db=HOGENOM6
HOVERGEN	HBG000639	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000639&db=HOVERGEN
HPA	HPA036055	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA036055
InParanoid	P40879	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P40879
IntAct	P40879	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P40879*
InterPro	IPR001902	http://www.ebi.ac.uk/interpro/entry/IPR001902
InterPro	IPR002645	http://www.ebi.ac.uk/interpro/entry/IPR002645
InterPro	IPR011547	http://www.ebi.ac.uk/interpro/entry/IPR011547
InterPro	IPR018045	http://www.ebi.ac.uk/interpro/entry/IPR018045
InterPro	IPR030321	http://www.ebi.ac.uk/interpro/entry/IPR030321
Jabion	1811	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1811
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H01174	http://www.genome.jp/dbget-bin/www_bget?H01174
KEGG_Gene	hsa:1811	http://www.genome.jp/dbget-bin/www_bget?hsa:1811
KEGG_Orthology	KO:K14078	http://www.genome.jp/dbget-bin/www_bget?KO:K14078
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
KEGG_Pathway	ko04978	http://www.genome.jp/kegg-bin/show_pathway?ko04978
MIM	126650	http://www.ncbi.nlm.nih.gov/omim/126650
MIM	214700	http://www.ncbi.nlm.nih.gov/omim/214700
MINT	MINT-1787198	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1787198
OMA	QETIGDC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QETIGDC
Orphanet	53689	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=53689
OrthoDB	EOG091G07RT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07RT
PANTHER	PTHR11814	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11814
PANTHER	PTHR11814:SF19	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11814:SF19
PROSITE	PS01130	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01130
PROSITE	PS50801	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50801
PSORT	swissprot:S26A3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S26A3_HUMAN
PSORT-B	swissprot:S26A3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S26A3_HUMAN
PSORT2	swissprot:S26A3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S26A3_HUMAN
Pfam	PF00916	http://pfam.xfam.org/family/PF00916
Pfam	PF01740	http://pfam.xfam.org/family/PF01740
PharmGKB	PA35044	http://www.pharmgkb.org/do/serve?objId=PA35044&objCls=Gene
Phobius	swissprot:S26A3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S26A3_HUMAN
PhylomeDB	P40879	http://phylomedb.org/?seqid=P40879
ProteinModelPortal	P40879	http://www.proteinmodelportal.org/query/uniprot/P40879
PubMed	11524734	http://www.ncbi.nlm.nih.gov/pubmed/11524734
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15766278	http://www.ncbi.nlm.nih.gov/pubmed/15766278
PubMed	19861545	http://www.ncbi.nlm.nih.gov/pubmed/19861545
PubMed	21150650	http://www.ncbi.nlm.nih.gov/pubmed/21150650
PubMed	21394828	http://www.ncbi.nlm.nih.gov/pubmed/21394828
PubMed	22159084	http://www.ncbi.nlm.nih.gov/pubmed/22159084
PubMed	7683425	http://www.ncbi.nlm.nih.gov/pubmed/7683425
PubMed	8140616	http://www.ncbi.nlm.nih.gov/pubmed/8140616
PubMed	8896562	http://www.ncbi.nlm.nih.gov/pubmed/8896562
PubMed	9554749	http://www.ncbi.nlm.nih.gov/pubmed/9554749
PubMed	9718329	http://www.ncbi.nlm.nih.gov/pubmed/9718329
Reactome	R-HSA-427601	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-427601
RefSeq	NP_000102	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000102
RefSeq	XP_011514169	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011514169
STRING	9606.ENSP00000345873	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000345873&targetmode=cogs
SUPFAM	SSF52091	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52091
TCDB	2.A.53.2.18	http://www.tcdb.org/search/result.php?tc=2.A.53.2.18
TIGRFAMs	TIGR00815	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00815
UCSC	uc003ver	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ver&org=rat
UniGene	Hs.1650	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.1650
UniProtKB	S26A3_HUMAN	http://www.uniprot.org/uniprot/S26A3_HUMAN
UniProtKB-AC	P40879	http://www.uniprot.org/uniprot/P40879
charge	swissprot:S26A3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S26A3_HUMAN
eggNOG	COG0659	http://eggnogapi.embl.de/nog_data/html/tree/COG0659
eggNOG	KOG0236	http://eggnogapi.embl.de/nog_data/html/tree/KOG0236
epestfind	swissprot:S26A3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S26A3_HUMAN
garnier	swissprot:S26A3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S26A3_HUMAN
helixturnhelix	swissprot:S26A3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S26A3_HUMAN
hmoment	swissprot:S26A3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S26A3_HUMAN
iep	swissprot:S26A3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S26A3_HUMAN
inforesidue	swissprot:S26A3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S26A3_HUMAN
neXtProt	NX_P40879	http://www.nextprot.org/db/entry/NX_P40879
octanol	swissprot:S26A3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S26A3_HUMAN
pepcoil	swissprot:S26A3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S26A3_HUMAN
pepdigest	swissprot:S26A3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S26A3_HUMAN
pepinfo	swissprot:S26A3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S26A3_HUMAN
pepnet	swissprot:S26A3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S26A3_HUMAN
pepstats	swissprot:S26A3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S26A3_HUMAN
pepwheel	swissprot:S26A3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S26A3_HUMAN
pepwindow	swissprot:S26A3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S26A3_HUMAN
sigcleave	swissprot:S26A3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S26A3_HUMAN
## Database	ID	URL or Descriptions
# AltName	SL9A7_HUMAN	Na(+)/H(+) exchanger 7
# AltName	SL9A7_HUMAN	Solute carrier family 9 member 7
# Ensembl	ENST00000328306	ENSP00000330320; ENSG00000065923
# ExpressionAtlas	Q96T83	baseline and differential
# FUNCTION	SL9A7_HUMAN	Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to Golgi volume and cation homeostasis. {ECO 0000269|PubMed 11279194}. 
# GO_component	GO:0000139	Golgi membrane; TAS:Reactome.
# GO_component	GO:0005802	trans-Golgi network; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IDA:UniProtKB.
# GO_component	GO:0055038	recycling endosome membrane; IDA:UniProtKB.
# GO_function	GO:0042803	protein homodimerization activity; TAS:UniProtKB.
# GO_function	SL9A7_HUMAN	GO 0015385 sodium proton antiporter activity; IDA UniProtKB.
# GO_function	SL9A7_HUMAN	GO 0015386 potassium proton antiporter activity; IDA UniProtKB.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006885	regulation of pH; IDA:UniProtKB.
# GO_process	GO:0051453	regulation of intracellular pH; IBA:GO_Central.
# GO_process	GO:0098719	sodium ion import across plasma membrane; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q96T83	HS
# HGNC	HGNC:17123	SLC9A7
# InterPro	IPR002090	Na/H_exchanger_6
# InterPro	IPR004709	NaH_exchanger
# InterPro	IPR006153	Cation/H_exchanger
# InterPro	IPR018422	Cation/H_exchanger_CPA1
# KEGG_Brite	ko02001	Solute carrier family
# MIM	300368	gene
# MISCELLANEOUS	SL9A7_HUMAN	Is not inhibited by amiloride but by benzamil and quinine. 
# Organism	SL9A7_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10110	PTHR10110; 2
# PRINTS	PR01084	NAHEXCHNGR
# PRINTS	PR01088	NAHEXCHNGR6
# Pfam	PF00999	Na_H_Exchanger
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-425986	Sodium/Proton exchangers
# RecName	SL9A7_HUMAN	Sodium/hydrogen exchanger 7
# RefSeq	NP_115980	NM_032591.2
# SIMILARITY	Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	SL9A7_HUMAN	Golgi apparatus, trans-Golgi network membrane {ECO 0000269|PubMed 15840657}; Multi-pass membrane protein {ECO 0000269|PubMed 15840657}. Recycling endosome membrane {ECO 0000269|PubMed 15840657}; Multi-pass membrane protein {ECO 0000269|PubMed 15840657}. 
# SUBUNIT	Interacts with SCAMP1, SCAMP2 and SCAMP5; may participate in its shuttling from trans-Golgi network to recycling endosomes. {ECO:0000269|PubMed	15840657}. 
# TCDB	2.A.36.1:the monovalent cation	proton antiporter-1 (cpa1) family
# TIGRFAMs	TIGR00840	b_cpa1
# TISSUE SPECIFICITY	Ubiquitously expressed. {ECO:0000269|PubMed	11279194}. 
# UCSC	uc004dgu	human
# eggNOG	COG0025	LUCA
# eggNOG	KOG1965	Eukaryota
BLAST	swissprot:SL9A7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SL9A7_HUMAN
BioCyc	ZFISH:ENSG00000065923-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000065923-MONOMER
COXPRESdb	84679	http://coxpresdb.jp/data/gene/84679.shtml
CleanEx	HS_SLC9A7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC9A7
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1074/jbc.M101319200	http://dx.doi.org/10.1074/jbc.M101319200
DOI	10.1242/jcs.02315	http://dx.doi.org/10.1242/jcs.02315
EMBL	AF298591	http://www.ebi.ac.uk/ena/data/view/AF298591
EMBL	AL022165	http://www.ebi.ac.uk/ena/data/view/AL022165
EMBL	AL022165	http://www.ebi.ac.uk/ena/data/view/AL022165
EMBL	AL050307	http://www.ebi.ac.uk/ena/data/view/AL050307
EMBL	AL050307	http://www.ebi.ac.uk/ena/data/view/AL050307
Ensembl	ENST00000328306	http://www.ensembl.org/id/ENST00000328306
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005802	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005802
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0055038	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055038
GO_function	GO:0015385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015385
GO_function	GO:0015386	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015386
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006885	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006885
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GO_process	GO:0098719	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098719
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC9A7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC9A7
GeneID	84679	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84679
GeneTree	ENSGT00760000119074	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119074
HGNC	HGNC:17123	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17123
HOGENOM	HOG000172307	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000172307&db=HOGENOM6
HOVERGEN	HBG055575	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG055575&db=HOVERGEN
HPA	HPA048938	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA048938
InParanoid	Q96T83	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96T83
IntAct	Q96T83	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96T83*
InterPro	IPR002090	http://www.ebi.ac.uk/interpro/entry/IPR002090
InterPro	IPR004709	http://www.ebi.ac.uk/interpro/entry/IPR004709
InterPro	IPR006153	http://www.ebi.ac.uk/interpro/entry/IPR006153
InterPro	IPR018422	http://www.ebi.ac.uk/interpro/entry/IPR018422
Jabion	84679	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=84679
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:84679	http://www.genome.jp/dbget-bin/www_bget?hsa:84679
KEGG_Orthology	KO:K12041	http://www.genome.jp/dbget-bin/www_bget?KO:K12041
MIM	300368	http://www.ncbi.nlm.nih.gov/omim/300368
PANTHER	PTHR10110	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10110
PRINTS	PR01084	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01084
PRINTS	PR01088	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01088
PSORT	swissprot:SL9A7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SL9A7_HUMAN
PSORT-B	swissprot:SL9A7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SL9A7_HUMAN
PSORT2	swissprot:SL9A7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SL9A7_HUMAN
Pfam	PF00999	http://pfam.xfam.org/family/PF00999
PharmGKB	PA38200	http://www.pharmgkb.org/do/serve?objId=PA38200&objCls=Gene
Phobius	swissprot:SL9A7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SL9A7_HUMAN
PhylomeDB	Q96T83	http://phylomedb.org/?seqid=Q96T83
ProteinModelPortal	Q96T83	http://www.proteinmodelportal.org/query/uniprot/Q96T83
PubMed	11279194	http://www.ncbi.nlm.nih.gov/pubmed/11279194
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	15840657	http://www.ncbi.nlm.nih.gov/pubmed/15840657
Reactome	R-HSA-425986	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425986
RefSeq	NP_115980	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_115980
SMR	Q96T83	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q96T83
STRING	9606.ENSP00000330320	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000330320&targetmode=cogs
TCDB	2.A.36.1	http://www.tcdb.org/search/result.php?tc=2.A.36.1
TIGRFAMs	TIGR00840	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00840
UCSC	uc004dgu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004dgu&org=rat
UniGene	Hs.91389	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.91389
UniProtKB	SL9A7_HUMAN	http://www.uniprot.org/uniprot/SL9A7_HUMAN
UniProtKB-AC	Q96T83	http://www.uniprot.org/uniprot/Q96T83
charge	swissprot:SL9A7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SL9A7_HUMAN
eggNOG	COG0025	http://eggnogapi.embl.de/nog_data/html/tree/COG0025
eggNOG	KOG1965	http://eggnogapi.embl.de/nog_data/html/tree/KOG1965
epestfind	swissprot:SL9A7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SL9A7_HUMAN
garnier	swissprot:SL9A7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SL9A7_HUMAN
helixturnhelix	swissprot:SL9A7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SL9A7_HUMAN
hmoment	swissprot:SL9A7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SL9A7_HUMAN
iep	swissprot:SL9A7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SL9A7_HUMAN
inforesidue	swissprot:SL9A7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SL9A7_HUMAN
neXtProt	NX_Q96T83	http://www.nextprot.org/db/entry/NX_Q96T83
octanol	swissprot:SL9A7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SL9A7_HUMAN
pepcoil	swissprot:SL9A7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SL9A7_HUMAN
pepdigest	swissprot:SL9A7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SL9A7_HUMAN
pepinfo	swissprot:SL9A7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SL9A7_HUMAN
pepnet	swissprot:SL9A7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SL9A7_HUMAN
pepstats	swissprot:SL9A7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SL9A7_HUMAN
pepwheel	swissprot:SL9A7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SL9A7_HUMAN
pepwindow	swissprot:SL9A7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SL9A7_HUMAN
sigcleave	swissprot:SL9A7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SL9A7_HUMAN
## Database	ID	URL or Descriptions
# AltName	GTR1_HUMAN	Glucose transporter type 1, erythrocyte/brain
# AltName	GTR1_HUMAN	HepG2 glucose transporter
# BioGrid	112404	25
# CDD	cd06174	MFS
# ChiTaRS	SLC2A1	human
# DISEASE	GTR1_HUMAN	Dystonia 9 (DYT9) [MIM 601042]  An autosomal dominant neurologic disorder characterized by childhood onset of paroxysmal choreoathetosis and progressive spastic paraplegia. Most patients show some degree of cognitive impairment. Other variable features may include seizures, migraine headaches, and ataxia. {ECO 0000269|PubMed 21832227}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	GTR1_HUMAN	Epilepsy, idiopathic generalized 12 (EIG12) [MIM 614847]  A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. Seizure types include juvenile myoclonic seizures, absence seizures, and generalized tonic-clonic seizures. In some EIG12 patients seizures may remit with age. {ECO 0000269|PubMed 19798636, ECO 0000269|PubMed 22282645, ECO 0000269|PubMed 23280796}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# DISEASE	GTR1_HUMAN	GLUT1 deficiency syndrome 1 (GLUT1DS1) [MIM 606777]  A neurologic disorder showing wide phenotypic variability. The most severe 'classic' phenotype comprises infantile-onset epileptic encephalopathy associated with delayed development, acquired microcephaly, motor incoordination, and spasticity. Onset of seizures, usually characterized by apneic episodes, staring spells, and episodic eye movements, occurs within the first 4 months of life. Other paroxysmal findings include intermittent ataxia, confusion, lethargy, sleep disturbance, and headache. Varying degrees of cognitive impairment can occur, ranging from learning disabilities to severe mental retardation. {ECO 0000269|PubMed 10227690, ECO 0000269|PubMed 10980529, ECO 0000269|PubMed 11136715, ECO 0000269|PubMed 11603379, ECO 0000269|PubMed 12325075, ECO 0000269|PubMed 15622525, ECO 0000269|PubMed 19901175, ECO 0000269|PubMed 20129935, ECO 0000269|PubMed 20221955, ECO 0000269|PubMed 20574033}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	GTR1_HUMAN	GLUT1 deficiency syndrome 2 (GLUT1DS2) [MIM 612126]  A clinically variable disorder characterized primarily by onset in childhood of paroxysmal exercise-induced dyskinesia. The dyskinesia involves transient abnormal involuntary movements, such as dystonia and choreoathetosis, induced by exercise or exertion, and affecting the exercised limbs. Some patients may also have epilepsy, most commonly childhood absence epilepsy. Mild mental retardation may also occur. In some patients involuntary exertion- induced dystonic, choreoathetotic, and ballistic movements may be associated with macrocytic hemolytic anemia. {ECO 0000269|PubMed 14605501, ECO 0000269|PubMed 18451999, ECO 0000269|PubMed 19630075, ECO 0000269|PubMed 19798636, ECO 0000269|PubMed 20129935, ECO 0000269|PubMed 20574033, ECO 0000269|PubMed 20621801, ECO 0000269|PubMed 20830593, ECO 0000269|PubMed 21204808}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	GTR1_HUMAN	Stomatin-deficient cryohydrocytosis with neurologic defects (SDCHCN) [MIM 608885]  A rare form of stomatocytosis characterized by episodic hemolytic anemia, cold-induced red cells cation leak, erratic hyperkalemia, neonatal hyperbilirubinemia, hepatosplenomegaly, cataracts, seizures, mental retardation, and movement disorder. {ECO 0000269|PubMed 21791420, ECO 0000269|PubMed 22492876}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00292	Etomidate
# Ensembl	ENST00000426263	ENSP00000416293; ENSG00000117394
# ExpressionAtlas	P11166	baseline and differential
# FUNCTION	GTR1_HUMAN	Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. {ECO 0000269|PubMed 18245775, ECO 0000269|PubMed 19449892}. 
# GO_component	GO:0000139	Golgi membrane; TAS:Reactome.
# GO_component	GO:0001939	female pronucleus; IEA:Ensembl.
# GO_component	GO:0005829	cytosol; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005901	caveola; IEA:Ensembl.
# GO_component	GO:0005911	cell-cell junction; IEA:Ensembl.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:Ensembl.
# GO_component	GO:0016324	apical plasma membrane; IEA:Ensembl.
# GO_component	GO:0030496	midbody; IDA:UniProtKB.
# GO_component	GO:0030864	cortical actin cytoskeleton; IDA:UniProtKB.
# GO_component	GO:0042470	melanosome; IEA:UniProtKB-SubCell.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_component	GO:0072562	blood microparticle; IDA:UniProtKB.
# GO_function	GO:0005355	glucose transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0033300	dehydroascorbic acid transporter activity; EXP:Reactome.
# GO_function	GO:0042910	xenobiotic transporter activity; IEA:Ensembl.
# GO_function	GO:0043621	protein self-association; IDA:UniProtKB.
# GO_function	GO:0055056	D-glucose transmembrane transporter activity; IMP:UniProtKB.
# GO_process	GO:0005989	lactose biosynthetic process; TAS:Reactome.
# GO_process	GO:0006461	protein complex assembly; IDA:UniProtKB.
# GO_process	GO:0006970	response to osmotic stress; IEA:Ensembl.
# GO_process	GO:0015758	glucose transport; IDA:UniProtKB.
# GO_process	GO:0019852	L-ascorbic acid metabolic process; TAS:Reactome.
# GO_process	GO:0042149	cellular response to glucose starvation; IEA:Ensembl.
# GO_process	GO:0050796	regulation of insulin secretion; TAS:Reactome.
# GO_process	GO:1904659	glucose transmembrane transport; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005856	cytoskeleton
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0005975	carbohydrate metabolic process
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P11166	HS
# HGNC	HGNC:11005	SLC2A1
# INTERACTION	GTR1_HUMAN	Self; NbExp=3; IntAct=EBI-717153, EBI-717153; 
# IntAct	P11166	25
# InterPro	IPR002439	Glu_transpt_1
# InterPro	IPR003663	Sugar/inositol_transpt
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR005829	Sugar_transporter_CS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H00831	[Nervous system disease] Primary dystonia
# KEGG_Disease	H00836	[Nervous system disease; Inherited metabolic disease] Glucose transport defect of the blood-brain barrier
# KEGG_Pathway	ko04066	HIF-1 signaling pathway
# KEGG_Pathway	ko04920	Adipocytokine signaling pathway
# KEGG_Pathway	ko04976	Bile secretion
# KEGG_Pathway	ko05166	HTLV-I infection
# KEGG_Pathway	ko05200	Pathways in cancer
# KEGG_Pathway	ko05211	Renal cell carcinoma
# MIM	138140	gene
# MIM	601042	phenotype
# MIM	606777	phenotype
# MIM	608885	phenotype
# MIM	612126	phenotype
# MIM	614847	phenotype
# Organism	GTR1_HUMAN	Homo sapiens (Human)
# Orphanet	168577	Hereditary cryohydrocytosis with reduced stomatin
# Orphanet	53583	Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity
# Orphanet	64280	Childhood absence epilepsy
# Orphanet	71277	Encephalopathy due to GLUT1 deficiency
# Orphanet	98811	Paroxysmal exertion-induced dyskinesia
# PDB	1SUK	Model; -; A=1-492
# PDB	4PYP	X-ray; 3.17 A; A=1-492
# PDB	5EQG	X-ray; 2.90 A; A=1-492
# PDB	5EQH	X-ray; 2.99 A; A=1-492
# PDB	5EQI	X-ray; 3.00 A; A=1-492
# PIR	A27217	A27217
# PRINTS	PR00171	SUGRTRNSPORT
# PRINTS	PR01190	GLUCTRSPORT1
# PROSITE	PS00216	SUGAR_TRANSPORT_1
# PROSITE	PS00217	SUGAR_TRANSPORT_2
# PROSITE	PS50850	MFS
# Pfam	PF00083	Sugar_tr
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-196836	Vitamin C (ascorbate) metabolism
# Reactome	R-HSA-422356	Regulation of insulin secretion
# Reactome	R-HSA-428790	Facilitative Na+-independent glucose transporters
# Reactome	R-HSA-5653890	Lactose synthesis
# Reactome	R-HSA-70153	Glucose transport
# RecName	GTR1_HUMAN	Solute carrier family 2, facilitated glucose transporter member 1
# RefSeq	NP_006507	NM_006516.2
# SIMILARITY	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	GTR1_HUMAN	Cell membrane; Multi-pass membrane protein. Melanosome. Note=Localizes primarily at the cell surface. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. 
# SUBUNIT	GTR1_HUMAN	Interacts with GIPC (via PDZ domain) (By similarity). Found in a complex with ADD2, DMTN and SLC2A1. Interacts (via C- terminus cytoplasmic region) with DMTN isoform 2. Interacts with SNX27; the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with STOM. {ECO 0000250, ECO 0000269|PubMed 18347014, ECO 0000269|PubMed 23219802, ECO 0000269|PubMed 23563491, ECO 0000269|PubMed 24847886}. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.1.1.28	the major facilitator superfamily (mfs)
# TIGRFAMs	TIGR00879	SP
# TISSUE SPECIFICITY	Detected in erythrocytes (at protein level). Expressed at variable levels in many human tissues. {ECO:0000269|PubMed	23219802}. 
# UCSC	uc001cik	human
# WEB RESOURCE	GTR1_HUMAN	Name=Wikipedia; Note=GLUT1 entry; URL="https //en.wikipedia.org/wiki/GLUT1";
# eggNOG	COG0477	LUCA
# eggNOG	KOG0569	Eukaryota
BLAST	swissprot:GTR1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GTR1_HUMAN
BioCyc	ZFISH:ENSG00000117394-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000117394-MONOMER
COXPRESdb	6513	http://coxpresdb.jp/data/gene/6513.shtml
CleanEx	HS_SLC2A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC2A1
DIP	DIP-23N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-23N
DOI	10.1001/archneurol.2009.236	http://dx.doi.org/10.1001/archneurol.2009.236
DOI	10.1002/1098-1004(200009)16:3<224::AID-HUMU5>3.3.CO	http://dx.doi.org/10.1002/1098-1004(200009)16:3<224::AID-HUMU5>3.3.CO
DOI	10.1002/ana.10311	http://dx.doi.org/10.1002/ana.10311
DOI	10.1002/ana.1222	http://dx.doi.org/10.1002/ana.1222
DOI	10.1002/ana.20331	http://dx.doi.org/10.1002/ana.20331
DOI	10.1002/ana.21724	http://dx.doi.org/10.1002/ana.21724
DOI	10.1002/ana.23702	http://dx.doi.org/10.1002/ana.23702
DOI	10.1002/mds.22507	http://dx.doi.org/10.1002/mds.22507
DOI	10.1007/s00415-010-5702-5	http://dx.doi.org/10.1007/s00415-010-5702-5
DOI	10.1016/j.bbamem.2012.11.030	http://dx.doi.org/10.1016/j.bbamem.2012.11.030
DOI	10.1016/j.jns.2010.05.017	http://dx.doi.org/10.1016/j.jns.2010.05.017
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1021/bi900521n	http://dx.doi.org/10.1021/bi900521n
DOI	10.1021/pr060363j	http://dx.doi.org/10.1021/pr060363j
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1023/A:1022544131826	http://dx.doi.org/10.1023/A:1022544131826
DOI	10.1023/A:1025999914822	http://dx.doi.org/10.1023/A:1025999914822
DOI	10.1038/nature13306	http://dx.doi.org/10.1038/nature13306
DOI	10.1038/nbt.1532	http://dx.doi.org/10.1038/nbt.1532
DOI	10.1038/ncb2721	http://dx.doi.org/10.1038/ncb2721
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1055/s-0030-1248264	http://dx.doi.org/10.1055/s-0030-1248264
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1074/jbc.M707818200	http://dx.doi.org/10.1074/jbc.M707818200
DOI	10.1074/jbc.M708896200	http://dx.doi.org/10.1074/jbc.M708896200
DOI	10.1093/brain/awp336	http://dx.doi.org/10.1093/brain/awp336
DOI	10.1093/hmg/10.1.63	http://dx.doi.org/10.1093/hmg/10.1.63
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1528-1167.2010.02726.x	http://dx.doi.org/10.1111/j.1528-1167.2010.02726.x
DOI	10.1126/science.3839598	http://dx.doi.org/10.1126/science.3839598
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1172/JCI34438	http://dx.doi.org/10.1172/JCI34438
DOI	10.1182/blood-2010-12-326645	http://dx.doi.org/10.1182/blood-2010-12-326645
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1210/jc.2012-1399	http://dx.doi.org/10.1210/jc.2012-1399
DOI	10.1212/WNL.0b013e3181eb58b4	http://dx.doi.org/10.1212/WNL.0b013e3181eb58b4
DOI	10.1212/WNL.0b013e31822e0479	http://dx.doi.org/10.1212/WNL.0b013e31822e0479
DOI	10.1212/WNL.0b013e318247ff54	http://dx.doi.org/10.1212/WNL.0b013e318247ff54
DOI	10.2337/diab.37.5.657	http://dx.doi.org/10.2337/diab.37.5.657
DrugBank	DB00292	http://www.drugbank.ca/drugs/DB00292
EMBL	AF070544	http://www.ebi.ac.uk/ena/data/view/AF070544
EMBL	AK292791	http://www.ebi.ac.uk/ena/data/view/AK292791
EMBL	AK312403	http://www.ebi.ac.uk/ena/data/view/AK312403
EMBL	AY034633	http://www.ebi.ac.uk/ena/data/view/AY034633
EMBL	BC118590	http://www.ebi.ac.uk/ena/data/view/BC118590
EMBL	CH471059	http://www.ebi.ac.uk/ena/data/view/CH471059
EMBL	K03195	http://www.ebi.ac.uk/ena/data/view/K03195
EMBL	M20653	http://www.ebi.ac.uk/ena/data/view/M20653
Ensembl	ENST00000426263	http://www.ensembl.org/id/ENST00000426263
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0001939	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001939
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005901
GO_component	GO:0005911	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005911
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0030496	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030496
GO_component	GO:0030864	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030864
GO_component	GO:0042470	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042470
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_component	GO:0072562	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072562
GO_function	GO:0005355	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005355
GO_function	GO:0033300	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033300
GO_function	GO:0042910	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042910
GO_function	GO:0043621	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043621
GO_function	GO:0055056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055056
GO_process	GO:0005989	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005989
GO_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GO_process	GO:0006970	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006970
GO_process	GO:0015758	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015758
GO_process	GO:0019852	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019852
GO_process	GO:0042149	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042149
GO_process	GO:0050796	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050796
GO_process	GO:1904659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1904659
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC2A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC2A1
GeneID	6513	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6513
GeneTree	ENSGT00760000119022	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119022
HGNC	HGNC:11005	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11005
HOVERGEN	HBG014816	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG014816&db=HOVERGEN
HPA	CAB002759	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB002759
HPA	HPA031345	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031345
HPA	HPA058494	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA058494
InParanoid	P11166	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P11166
IntAct	P11166	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P11166*
InterPro	IPR002439	http://www.ebi.ac.uk/interpro/entry/IPR002439
InterPro	IPR003663	http://www.ebi.ac.uk/interpro/entry/IPR003663
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR005829	http://www.ebi.ac.uk/interpro/entry/IPR005829
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	6513	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6513
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00831	http://www.genome.jp/dbget-bin/www_bget?H00831
KEGG_Disease	H00836	http://www.genome.jp/dbget-bin/www_bget?H00836
KEGG_Gene	hsa:6513	http://www.genome.jp/dbget-bin/www_bget?hsa:6513
KEGG_Orthology	KO:K07299	http://www.genome.jp/dbget-bin/www_bget?KO:K07299
KEGG_Pathway	ko04066	http://www.genome.jp/kegg-bin/show_pathway?ko04066
KEGG_Pathway	ko04920	http://www.genome.jp/kegg-bin/show_pathway?ko04920
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
KEGG_Pathway	ko05166	http://www.genome.jp/kegg-bin/show_pathway?ko05166
KEGG_Pathway	ko05200	http://www.genome.jp/kegg-bin/show_pathway?ko05200
KEGG_Pathway	ko05211	http://www.genome.jp/kegg-bin/show_pathway?ko05211
MIM	138140	http://www.ncbi.nlm.nih.gov/omim/138140
MIM	601042	http://www.ncbi.nlm.nih.gov/omim/601042
MIM	606777	http://www.ncbi.nlm.nih.gov/omim/606777
MIM	608885	http://www.ncbi.nlm.nih.gov/omim/608885
MIM	612126	http://www.ncbi.nlm.nih.gov/omim/612126
MIM	614847	http://www.ncbi.nlm.nih.gov/omim/614847
MINT	MINT-1386229	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1386229
OMA	MLMMNLL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MLMMNLL
Orphanet	168577	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=168577
Orphanet	53583	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=53583
Orphanet	64280	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=64280
Orphanet	71277	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=71277
Orphanet	98811	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98811
OrthoDB	EOG091G0A9K	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0A9K
PDB	1SUK	http://www.ebi.ac.uk/pdbe-srv/view/entry/1SUK
PDB	4PYP	http://www.ebi.ac.uk/pdbe-srv/view/entry/4PYP
PDB	5EQG	http://www.ebi.ac.uk/pdbe-srv/view/entry/5EQG
PDB	5EQH	http://www.ebi.ac.uk/pdbe-srv/view/entry/5EQH
PDB	5EQI	http://www.ebi.ac.uk/pdbe-srv/view/entry/5EQI
PDBsum	1SUK	http://www.ebi.ac.uk/pdbsum/1SUK
PDBsum	4PYP	http://www.ebi.ac.uk/pdbsum/4PYP
PDBsum	5EQG	http://www.ebi.ac.uk/pdbsum/5EQG
PDBsum	5EQH	http://www.ebi.ac.uk/pdbsum/5EQH
PDBsum	5EQI	http://www.ebi.ac.uk/pdbsum/5EQI
PRINTS	PR00171	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00171
PRINTS	PR01190	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01190
PROSITE	PS00216	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00216
PROSITE	PS00217	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00217
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:GTR1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GTR1_HUMAN
PSORT-B	swissprot:GTR1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GTR1_HUMAN
PSORT2	swissprot:GTR1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GTR1_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
PharmGKB	PA35875	http://www.pharmgkb.org/do/serve?objId=PA35875&objCls=Gene
Phobius	swissprot:GTR1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GTR1_HUMAN
PhylomeDB	P11166	http://phylomedb.org/?seqid=P11166
ProteinModelPortal	P11166	http://www.proteinmodelportal.org/query/uniprot/P11166
PubMed	10227690	http://www.ncbi.nlm.nih.gov/pubmed/10227690
PubMed	10980529	http://www.ncbi.nlm.nih.gov/pubmed/10980529
PubMed	11136715	http://www.ncbi.nlm.nih.gov/pubmed/11136715
PubMed	11603379	http://www.ncbi.nlm.nih.gov/pubmed/11603379
PubMed	12325075	http://www.ncbi.nlm.nih.gov/pubmed/12325075
PubMed	14605501	http://www.ncbi.nlm.nih.gov/pubmed/14605501
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15622525	http://www.ncbi.nlm.nih.gov/pubmed/15622525
PubMed	17081065	http://www.ncbi.nlm.nih.gov/pubmed/17081065
PubMed	18245775	http://www.ncbi.nlm.nih.gov/pubmed/18245775
PubMed	18347014	http://www.ncbi.nlm.nih.gov/pubmed/18347014
PubMed	18451999	http://www.ncbi.nlm.nih.gov/pubmed/18451999
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	19349973	http://www.ncbi.nlm.nih.gov/pubmed/19349973
PubMed	19449892	http://www.ncbi.nlm.nih.gov/pubmed/19449892
PubMed	19630075	http://www.ncbi.nlm.nih.gov/pubmed/19630075
PubMed	19798636	http://www.ncbi.nlm.nih.gov/pubmed/19798636
PubMed	19901175	http://www.ncbi.nlm.nih.gov/pubmed/19901175
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	20129935	http://www.ncbi.nlm.nih.gov/pubmed/20129935
PubMed	20221955	http://www.ncbi.nlm.nih.gov/pubmed/20221955
PubMed	20574033	http://www.ncbi.nlm.nih.gov/pubmed/20574033
PubMed	20621801	http://www.ncbi.nlm.nih.gov/pubmed/20621801
PubMed	20830593	http://www.ncbi.nlm.nih.gov/pubmed/20830593
PubMed	21204808	http://www.ncbi.nlm.nih.gov/pubmed/21204808
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	21791420	http://www.ncbi.nlm.nih.gov/pubmed/21791420
PubMed	21832227	http://www.ncbi.nlm.nih.gov/pubmed/21832227
PubMed	22282645	http://www.ncbi.nlm.nih.gov/pubmed/22282645
PubMed	22492876	http://www.ncbi.nlm.nih.gov/pubmed/22492876
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	23219802	http://www.ncbi.nlm.nih.gov/pubmed/23219802
PubMed	23280796	http://www.ncbi.nlm.nih.gov/pubmed/23280796
PubMed	23563491	http://www.ncbi.nlm.nih.gov/pubmed/23563491
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	24847886	http://www.ncbi.nlm.nih.gov/pubmed/24847886
PubMed	2834252	http://www.ncbi.nlm.nih.gov/pubmed/2834252
PubMed	3839598	http://www.ncbi.nlm.nih.gov/pubmed/3839598
Reactome	R-HSA-196836	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-196836
Reactome	R-HSA-422356	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-422356
Reactome	R-HSA-428790	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428790
Reactome	R-HSA-5653890	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5653890
Reactome	R-HSA-70153	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-70153
RefSeq	NP_006507	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006507
SMR	P11166	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P11166
STRING	9606.ENSP00000416293	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000416293&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.1.28	http://www.tcdb.org/search/result.php?tc=2.A.1.1.28
TIGRFAMs	TIGR00879	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00879
UCSC	uc001cik	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001cik&org=rat
UniGene	Hs.473721	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.473721
UniProtKB	GTR1_HUMAN	http://www.uniprot.org/uniprot/GTR1_HUMAN
UniProtKB-AC	P11166	http://www.uniprot.org/uniprot/P11166
charge	swissprot:GTR1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GTR1_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG0569	http://eggnogapi.embl.de/nog_data/html/tree/KOG0569
epestfind	swissprot:GTR1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GTR1_HUMAN
garnier	swissprot:GTR1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GTR1_HUMAN
helixturnhelix	swissprot:GTR1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GTR1_HUMAN
hmoment	swissprot:GTR1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GTR1_HUMAN
iep	swissprot:GTR1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GTR1_HUMAN
inforesidue	swissprot:GTR1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GTR1_HUMAN
neXtProt	NX_P11166	http://www.nextprot.org/db/entry/NX_P11166
octanol	swissprot:GTR1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GTR1_HUMAN
pepcoil	swissprot:GTR1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GTR1_HUMAN
pepdigest	swissprot:GTR1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GTR1_HUMAN
pepinfo	swissprot:GTR1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GTR1_HUMAN
pepnet	swissprot:GTR1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GTR1_HUMAN
pepstats	swissprot:GTR1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GTR1_HUMAN
pepwheel	swissprot:GTR1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GTR1_HUMAN
pepwindow	swissprot:GTR1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GTR1_HUMAN
sigcleave	swissprot:GTR1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GTR1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CSEN_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=KChIP3.1; IsoId=Q9Y2W7-1; Sequence=Displayed; Name=2; Synonyms=KChIP3.2, KChIP4.2; IsoId=Q9Y2W7-2; Sequence=VSP_015040; Note=No experimental confirmation available.; Name=3; Synonyms=KChip3.x; IsoId=Q9Y2W7-3; Sequence=VSP_040982, VSP_040983; 
# AltName	CSEN_HUMAN	A-type potassium channel modulatory protein 3
# AltName	CSEN_HUMAN	DRE-antagonist modulator
# AltName	CSEN_HUMAN	Kv channel-interacting protein 3
# BioGrid	119042	21
# CCDS	CCDS2013	-. [Q9Y2W7-1]
# CCDS	CCDS33245	-. [Q9Y2W7-3]
# CDD	cd00051	EFh; 2
# ChiTaRS	KCNIP3	human
# Ensembl	ENST00000295225	ENSP00000295225; ENSG00000115041. [Q9Y2W7-1]
# Ensembl	ENST00000468529	ENSP00000417499; ENSG00000115041. [Q9Y2W7-3]
# ExpressionAtlas	Q9Y2W7	baseline and differential
# FUNCTION	CSEN_HUMAN	Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity). {ECO 0000250|UniProtKB Q9QXT8}. 
# FUNCTION	CSEN_HUMAN	May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of beta-amyloid formation. {ECO 0000269|PubMed 11259376, ECO 0000269|PubMed 11988022, ECO 0000269|PubMed 9771752}. 
# FUNCTION	CSEN_HUMAN	Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. {ECO 0000269|PubMed 10676964, ECO 0000269|PubMed 12829703, ECO 0000269|PubMed 15485870, ECO 0000269|PubMed 16123112, ECO 0000269|PubMed 18957440}. 
# GO_component	GO:0005634	nucleus; IEA:UniProtKB-SubCell.
# GO_component	GO:0005783	endoplasmic reticulum; IEA:UniProtKB-SubCell.
# GO_component	GO:0005794	Golgi apparatus; IEA:UniProtKB-SubCell.
# GO_component	GO:0005829	cytosol; ISS:UniProtKB.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008076	voltage-gated potassium channel complex; ISS:UniProtKB.
# GO_component	GO:0030425	dendrite; IEA:Ensembl.
# GO_component	GO:0032993	protein-DNA complex; IEA:Ensembl.
# GO_component	GO:0043679	axon terminus; IEA:Ensembl.
# GO_function	GO:0003677	DNA binding; TAS:ProtInc.
# GO_function	GO:0003714	transcription corepressor activity; TAS:ProtInc.
# GO_function	GO:0005244	voltage-gated ion channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0005267	potassium channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0005509	calcium ion binding; TAS:ProtInc.
# GO_function	GO:0015459	potassium channel regulator activity; ISS:UniProtKB.
# GO_function	GO:0043565	sequence-specific DNA binding; IEA:Ensembl.
# GO_process	GO:0000122	negative regulation of transcription from RNA polymerase II promoter; IEA:GOC.
# GO_process	GO:0006351	transcription, DNA-templated; IEA:UniProtKB-KW.
# GO_process	GO:0006357	regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
# GO_process	GO:0006886	intracellular protein transport; IEA:Ensembl.
# GO_process	GO:0006915	apoptotic process; IEA:UniProtKB-KW.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:0072659	protein localization to plasma membrane; ISS:UniProtKB.
# GO_process	GO:1901379	regulation of potassium ion transmembrane transport; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0000988	transcription factor activity, protein binding
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0003677	DNA binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007009	plasma membrane organization
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0008219	cell death
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# Gene3D	1.10.238.10	-; 3.
# Genevisible	Q9Y2W7	HS
# HGNC	HGNC:15523	KCNIP3
# INTERACTION	CSEN_HUMAN	Q8N6Q3 CD177; NbExp=6; IntAct=EBI-751501, EBI-747170; P08069 IGF1R; NbExp=5; IntAct=EBI-751501, EBI-475981; Q17RA0 IL6ST; NbExp=3; IntAct=EBI-751501, EBI-10238517; Q7Z434 MAVS; NbExp=3; IntAct=EBI-751501, EBI-995373; 
# IntAct	Q9Y2W7	7
# InterPro	IPR002048	EF_hand_dom
# InterPro	IPR011992	EF-hand-dom_pair
# InterPro	IPR018247	EF_Hand_1_Ca_BS
# InterPro	IPR028846	Recoverin
# MIM	604662	gene
# Organism	CSEN_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR23055	PTHR23055
# PDB	2E6W	NMR; -; A=161-256
# PROSITE	PS00018	EF_HAND_1; 2
# PROSITE	PS50222	EF_HAND_2; 3
# PTM	CSEN_HUMAN	Palmitoylated. Palmitoylation enhances association with the plasma membrane (By similarity). {ECO 0000250}. 
# PTM	CSEN_HUMAN	Phosphorylation at Ser-63 inhibits cleavage by CASP3. {ECO 0000269|PubMed 11278424, ECO 0000269|PubMed 12837631}. 
# PTM	CSEN_HUMAN	Proteolytically cleaved by caspase-3. {ECO 0000269|PubMed 11278424}. 
# Pfam	PF13499	EF-hand_7
# Pfam	PF13833	EF-hand_8
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-5576894	Phase 1 - inactivation of fast Na+ channels
# RecName	CSEN_HUMAN	Calsenilin
# RefSeq	NP_001030086	NM_001034914.1. [Q9Y2W7-3]
# RefSeq	NP_038462	NM_013434.4. [Q9Y2W7-1]
# SIMILARITY	Belongs to the recoverin family. {ECO	0000305}. 
# SIMILARITY	Contains 4 EF-hand domains. {ECO:0000255|PROSITE- ProRule	PRU00448}.
# SMART	SM00054	EFh; 3
# SUBCELLULAR LOCATION	CSEN_HUMAN	Cytoplasm {ECO 0000269|PubMed 18957440}. Cell membrane {ECO 0000269|PubMed 15485870, ECO 0000269|PubMed 18957440}; Lipid-anchor {ECO 0000250}. Endoplasmic reticulum {ECO 0000269|PubMed 11278424, ECO 0000269|PubMed 18957440}. Golgi apparatus {ECO 0000269|PubMed 11278424}. Nucleus {ECO 0000269|PubMed 21070824}. Note=Also membrane-bound, associated with the plasma membrane (PubMed 15485870). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus. {ECO 0000269|PubMed 11278424, ECO 0000269|PubMed 15485870, ECO 0000269|PubMed 21070824}. 
# SUBUNIT	CSEN_HUMAN	Binds to DNA as a homomultimer. Dimerization is induced by binding to calcium (PubMed 17962406). Interacts with the C- terminus of PSEN1 and PSEN2 and with PSEN2 CTF subunit. Associates with KCN1. Component of heteromultimeric potassium channels. Identified in potassium channel complexes containing KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10 (By similarity). Interacts with KCND2 and KCND3. {ECO 0000250|UniProtKB Q9QXT8, ECO 0000269|PubMed 11278424, ECO 0000269|PubMed 15485870, ECO 0000269|PubMed 17962406, ECO 0000269|PubMed 18957440}. 
# SUPFAM	SSF47473	SSF47473
# TISSUE SPECIFICITY	Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease. {ECO:0000269|PubMed	14720210}. 
# UCSC	uc002sup	human. [Q9Y2W7-1]
# eggNOG	COG5126	LUCA
# eggNOG	KOG0044	Eukaryota
BLAST	swissprot:CSEN_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CSEN_HUMAN
BioCyc	ZFISH:ENSG00000115041-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000115041-MONOMER
COXPRESdb	30818	http://coxpresdb.jp/data/gene/30818.shtml
CleanEx	HS_KCNIP3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNIP3
DOI	10.1006/mcne.2001.1096	http://dx.doi.org/10.1006/mcne.2001.1096
DOI	10.1016/S1044-7431(03)00072-1	http://dx.doi.org/10.1016/S1044-7431(03)00072-1
DOI	10.1016/j.bbamcr.2010.11.001	http://dx.doi.org/10.1016/j.bbamcr.2010.11.001
DOI	10.1016/j.ygeno.2005.07.001	http://dx.doi.org/10.1016/j.ygeno.2005.07.001
DOI	10.1038/18044	http://dx.doi.org/10.1038/18044
DOI	10.1038/2673	http://dx.doi.org/10.1038/2673
DOI	10.1038/35000592	http://dx.doi.org/10.1038/35000592
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M008597200	http://dx.doi.org/10.1074/jbc.M008597200
DOI	10.1074/jbc.M306142200	http://dx.doi.org/10.1074/jbc.M306142200
DOI	10.1074/jbc.M409721200	http://dx.doi.org/10.1074/jbc.M409721200
DOI	10.1074/jbc.M806852200	http://dx.doi.org/10.1074/jbc.M806852200
DOI	10.1096/fj.00-0541fje	http://dx.doi.org/10.1096/fj.00-0541fje
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1110/ps.072928007	http://dx.doi.org/10.1110/ps.072928007
DOI	10.1111/j.1471-4159.2004.02159.x	http://dx.doi.org/10.1111/j.1471-4159.2004.02159.x
DOI	10.1113/jphysiol.2005.087858	http://dx.doi.org/10.1113/jphysiol.2005.087858
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
EMBL	AC009238	http://www.ebi.ac.uk/ena/data/view/AC009238
EMBL	AF120102	http://www.ebi.ac.uk/ena/data/view/AF120102
EMBL	AF199599	http://www.ebi.ac.uk/ena/data/view/AF199599
EMBL	AF367022	http://www.ebi.ac.uk/ena/data/view/AF367022
EMBL	AJ131730	http://www.ebi.ac.uk/ena/data/view/AJ131730
EMBL	AJ131730	http://www.ebi.ac.uk/ena/data/view/AJ131730
EMBL	AK315437	http://www.ebi.ac.uk/ena/data/view/AK315437
EMBL	BC012850	http://www.ebi.ac.uk/ena/data/view/BC012850
EMBL	BT020075	http://www.ebi.ac.uk/ena/data/view/BT020075
EMBL	CH471219	http://www.ebi.ac.uk/ena/data/view/CH471219
EMBL	DQ148485	http://www.ebi.ac.uk/ena/data/view/DQ148485
EMBL	DQ148486	http://www.ebi.ac.uk/ena/data/view/DQ148486
Ensembl	ENST00000295225	http://www.ensembl.org/id/ENST00000295225
Ensembl	ENST00000468529	http://www.ensembl.org/id/ENST00000468529
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0032993	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032993
GO_component	GO:0043679	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043679
GO_function	GO:0003677	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GO_function	GO:0003714	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003714
GO_function	GO:0005244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005244
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0015459	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015459
GO_function	GO:0043565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565
GO_process	GO:0000122	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000122
GO_process	GO:0006351	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351
GO_process	GO:0006357	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006357
GO_process	GO:0006886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006886
GO_process	GO:0006915	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006915
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:0072659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072659
GO_process	GO:1901379	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901379
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0000988	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000988
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0003677	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007009
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0008219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
Gene3D	1.10.238.10	http://www.cathdb.info/version/latest/superfamily/1.10.238.10
GeneCards	KCNIP3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNIP3
GeneID	30818	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=30818
GeneTree	ENSGT00760000118820	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118820
HGNC	HGNC:15523	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:15523
HOGENOM	HOG000233019	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233019&db=HOGENOM6
HOVERGEN	HBG108179	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108179&db=HOVERGEN
HPA	CAB006907	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB006907
InParanoid	Q9Y2W7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y2W7
IntAct	Q9Y2W7	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9Y2W7*
InterPro	IPR002048	http://www.ebi.ac.uk/interpro/entry/IPR002048
InterPro	IPR011992	http://www.ebi.ac.uk/interpro/entry/IPR011992
InterPro	IPR018247	http://www.ebi.ac.uk/interpro/entry/IPR018247
InterPro	IPR028846	http://www.ebi.ac.uk/interpro/entry/IPR028846
Jabion	30818	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=30818
KEGG_Gene	hsa:30818	http://www.genome.jp/dbget-bin/www_bget?hsa:30818
MIM	604662	http://www.ncbi.nlm.nih.gov/omim/604662
MINT	MINT-1453732	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1453732
OMA	FGILEPM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FGILEPM
PANTHER	PTHR23055	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23055
PDB	2E6W	http://www.ebi.ac.uk/pdbe-srv/view/entry/2E6W
PDBsum	2E6W	http://www.ebi.ac.uk/pdbsum/2E6W
PROSITE	PS00018	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00018
PROSITE	PS50222	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50222
PSORT	swissprot:CSEN_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CSEN_HUMAN
PSORT-B	swissprot:CSEN_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CSEN_HUMAN
PSORT2	swissprot:CSEN_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CSEN_HUMAN
Pfam	PF13499	http://pfam.xfam.org/family/PF13499
Pfam	PF13833	http://pfam.xfam.org/family/PF13833
PharmGKB	PA26934	http://www.pharmgkb.org/do/serve?objId=PA26934&objCls=Gene
Phobius	swissprot:CSEN_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CSEN_HUMAN
PhylomeDB	Q9Y2W7	http://phylomedb.org/?seqid=Q9Y2W7
ProteinModelPortal	Q9Y2W7	http://www.proteinmodelportal.org/query/uniprot/Q9Y2W7
PubMed	10078534	http://www.ncbi.nlm.nih.gov/pubmed/10078534
PubMed	10676964	http://www.ncbi.nlm.nih.gov/pubmed/10676964
PubMed	11259376	http://www.ncbi.nlm.nih.gov/pubmed/11259376
PubMed	11278424	http://www.ncbi.nlm.nih.gov/pubmed/11278424
PubMed	11988022	http://www.ncbi.nlm.nih.gov/pubmed/11988022
PubMed	12829703	http://www.ncbi.nlm.nih.gov/pubmed/12829703
PubMed	12837631	http://www.ncbi.nlm.nih.gov/pubmed/12837631
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	14720210	http://www.ncbi.nlm.nih.gov/pubmed/14720210
PubMed	15485870	http://www.ncbi.nlm.nih.gov/pubmed/15485870
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	16112838	http://www.ncbi.nlm.nih.gov/pubmed/16112838
PubMed	16123112	http://www.ncbi.nlm.nih.gov/pubmed/16123112
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	17962406	http://www.ncbi.nlm.nih.gov/pubmed/17962406
PubMed	18957440	http://www.ncbi.nlm.nih.gov/pubmed/18957440
PubMed	21070824	http://www.ncbi.nlm.nih.gov/pubmed/21070824
PubMed	9771752	http://www.ncbi.nlm.nih.gov/pubmed/9771752
Reactome	R-HSA-5576894	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576894
RefSeq	NP_001030086	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001030086
RefSeq	NP_038462	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_038462
SMART	SM00054	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00054
SMR	Q9Y2W7	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9Y2W7
STRING	9606.ENSP00000295225	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000295225&targetmode=cogs
SUPFAM	SSF47473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47473
UCSC	uc002sup	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002sup&org=rat
UniGene	Hs.437376	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.437376
UniProtKB	CSEN_HUMAN	http://www.uniprot.org/uniprot/CSEN_HUMAN
UniProtKB-AC	Q9Y2W7	http://www.uniprot.org/uniprot/Q9Y2W7
charge	swissprot:CSEN_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CSEN_HUMAN
eggNOG	COG5126	http://eggnogapi.embl.de/nog_data/html/tree/COG5126
eggNOG	KOG0044	http://eggnogapi.embl.de/nog_data/html/tree/KOG0044
epestfind	swissprot:CSEN_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CSEN_HUMAN
garnier	swissprot:CSEN_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CSEN_HUMAN
helixturnhelix	swissprot:CSEN_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CSEN_HUMAN
hmoment	swissprot:CSEN_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CSEN_HUMAN
iep	swissprot:CSEN_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CSEN_HUMAN
inforesidue	swissprot:CSEN_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CSEN_HUMAN
neXtProt	NX_Q9Y2W7	http://www.nextprot.org/db/entry/NX_Q9Y2W7
octanol	swissprot:CSEN_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CSEN_HUMAN
pepcoil	swissprot:CSEN_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CSEN_HUMAN
pepdigest	swissprot:CSEN_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CSEN_HUMAN
pepinfo	swissprot:CSEN_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CSEN_HUMAN
pepnet	swissprot:CSEN_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CSEN_HUMAN
pepstats	swissprot:CSEN_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CSEN_HUMAN
pepwheel	swissprot:CSEN_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CSEN_HUMAN
pepwindow	swissprot:CSEN_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CSEN_HUMAN
sigcleave	swissprot:CSEN_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CSEN_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ZNT8_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8IWU4-1; Sequence=Displayed; Name=2; IsoId=Q8IWU4-2; Sequence=VSP_024025; 
# AltName	ZNT8_HUMAN	Solute carrier family 30 member 8
# CCDS	CCDS55272	-. [Q8IWU4-2]
# CCDS	CCDS6322	-. [Q8IWU4-1]
# DOMAIN	ZNT8_HUMAN	Contains a histidine-rich region, HXXXXXHNH-motif, which is a ligand for zinc. {ECO 0000250}. 
# Ensembl	ENST00000427715	ENSP00000407505; ENSG00000164756. [Q8IWU4-2]
# Ensembl	ENST00000456015	ENSP00000415011; ENSG00000164756. [Q8IWU4-1]
# Ensembl	ENST00000519688	ENSP00000431069; ENSG00000164756. [Q8IWU4-2]
# Ensembl	ENST00000521243	ENSP00000428545; ENSG00000164756. [Q8IWU4-2]
# ExpressionAtlas	Q8IWU4	baseline and differential
# FUNCTION	ZNT8_HUMAN	Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta- cells. {ECO 0000269|PubMed 16984975}. 
# GO_component	GO:0005886	plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0016023	cytoplasmic, membrane-bounded vesicle; ISS:BHF-UCL.
# GO_component	GO:0030141	secretory granule; IDA:BHF-UCL.
# GO_component	GO:0030658	transport vesicle membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0030667	secretory granule membrane; TAS:Reactome.
# GO_function	GO:0005385	zinc ion transmembrane transporter activity; IDA:BHF-UCL.
# GO_function	GO:0008270	zinc ion binding; IC:BHF-UCL.
# GO_function	GO:0042803	protein homodimerization activity; ISS:BHF-UCL.
# GO_process	GO:0006829	zinc II ion transport; IDA:BHF-UCL.
# GO_process	GO:0006882	cellular zinc ion homeostasis; ISS:BHF-UCL.
# GO_process	GO:0009749	response to glucose; IMP:BHF-UCL.
# GO_process	GO:0010043	response to zinc ion; IBA:GO_Central.
# GO_process	GO:0030073	insulin secretion; IMP:BHF-UCL.
# GO_process	GO:0032024	positive regulation of insulin secretion; ISS:BHF-UCL.
# GO_process	GO:0032119	sequestering of zinc ion; IDA:BHF-UCL.
# GO_process	GO:0034341	response to interferon-gamma; IEA:Ensembl.
# GO_process	GO:0060627	regulation of vesicle-mediated transport; ISS:BHF-UCL.
# GO_process	GO:0061088	regulation of sequestering of zinc ion; ISS:BHF-UCL.
# GO_process	GO:0070555	response to interleukin-1; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# Gene3D	1.20.1510.10	-; 1.
# Genevisible	Q8IWU4	HS
# HGNC	HGNC:20303	SLC30A8
# INTERACTION	ZNT8_HUMAN	Q96BA8 CREB3L1; NbExp=3; IntAct=EBI-10262251, EBI-6942903; 
# IntAct	Q8IWU4	4
# InterPro	IPR002524	Cation_efflux
# InterPro	IPR027469	Cation_efflux_TMD
# InterPro	IPR033572	ZnT-8
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H00409	[Metabolic disease; Endocrine disease] Type II diabetes mellitus
# MIM	125853	phenotype
# MIM	611145	gene
# Organism	ZNT8_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11562	PTHR11562
# PANTHER	PTHR11562:SF37	PTHR11562:SF37
# POLYMORPHISM	Variant Trp-325 is a risk factor that confers susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM) [MIM	125853]. 
# Pfam	PF01545	Cation_efflux
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-264876	Insulin processing
# Reactome	R-HSA-435368	Zinc efflux and compartmentalization by the SLC30 family
# RecName	ZNT8_HUMAN	Zinc transporter 8
# RefSeq	NP_001166282	NM_001172811.1. [Q8IWU4-2]
# RefSeq	NP_001166284	NM_001172813.1. [Q8IWU4-2]
# RefSeq	NP_001166285	NM_001172814.1. [Q8IWU4-2]
# RefSeq	NP_001166286	NM_001172815.2. [Q8IWU4-2]
# RefSeq	NP_776250	NM_173851.2. [Q8IWU4-1]
# SIMILARITY	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	ZNT8_HUMAN	Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. Cytoplasmic vesicle, secretory vesicle membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. Note=Associated with insulin and glucagon secretory granules. {ECO 0000250}. 
# SUBUNIT	Homodimer. {ECO	0000250}. 
# TCDB	2.A.4.3	the cation diffusion facilitator (cdf) family
# TIGRFAMs	TIGR01297	CDF
# TISSUE SPECIFICITY	ZNT8_HUMAN	In the endocrine pancreas, expressed in insulin-producing beta cells. Expressed at relatively high levels in subcutaneous fat tissue from lean persons; much lower levels in visceral fat, whether from lean or obese individuals, and in subcutaneous fat tissue from obese individuals. Expressed in peripheral blood mononuclear cells, including T-cells and B-cells, with great variation among individuals ranging from negative to strongly positive. {ECO 0000269|PubMed 15331542, ECO 0000269|PubMed 16158222, ECO 0000269|PubMed 16984975, ECO 0000269|PubMed 17118530, ECO 0000269|PubMed 17971500}. 
# UCSC	uc003yog	human. [Q8IWU4-1]
# eggNOG	COG1230	LUCA
# eggNOG	KOG1482	Eukaryota
BLAST	swissprot:ZNT8_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ZNT8_HUMAN
COXPRESdb	169026	http://coxpresdb.jp/data/gene/169026.shtml
CleanEx	HS_SLC30A8	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC30A8
DOI	10.1007/s10534-005-3687-9	http://dx.doi.org/10.1007/s10534-005-3687-9
DOI	10.1016/j.mce.2006.10.010	http://dx.doi.org/10.1016/j.mce.2006.10.010
DOI	10.1038/nature04406	http://dx.doi.org/10.1038/nature04406
DOI	10.1038/nature05616	http://dx.doi.org/10.1038/nature05616
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.1189/jlb.0307148	http://dx.doi.org/10.1189/jlb.0307148
DOI	10.1242/jcs.03164	http://dx.doi.org/10.1242/jcs.03164
DOI	10.2337/diabetes.53.9.2330	http://dx.doi.org/10.2337/diabetes.53.9.2330
EMBL	AC027419	http://www.ebi.ac.uk/ena/data/view/AC027419
EMBL	AC084114	http://www.ebi.ac.uk/ena/data/view/AC084114
EMBL	AK298294	http://www.ebi.ac.uk/ena/data/view/AK298294
EMBL	AL713790	http://www.ebi.ac.uk/ena/data/view/AL713790
EMBL	AY117411	http://www.ebi.ac.uk/ena/data/view/AY117411
EMBL	BC126446	http://www.ebi.ac.uk/ena/data/view/BC126446
EMBL	CH471060	http://www.ebi.ac.uk/ena/data/view/CH471060
EMBL	EF560713	http://www.ebi.ac.uk/ena/data/view/EF560713
Ensembl	ENST00000427715	http://www.ensembl.org/id/ENST00000427715
Ensembl	ENST00000456015	http://www.ensembl.org/id/ENST00000456015
Ensembl	ENST00000519688	http://www.ensembl.org/id/ENST00000519688
Ensembl	ENST00000521243	http://www.ensembl.org/id/ENST00000521243
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016023	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016023
GO_component	GO:0030141	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030141
GO_component	GO:0030658	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030658
GO_component	GO:0030667	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030667
GO_function	GO:0005385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005385
GO_function	GO:0008270	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_process	GO:0006829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006829
GO_process	GO:0006882	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006882
GO_process	GO:0009749	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009749
GO_process	GO:0010043	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010043
GO_process	GO:0030073	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030073
GO_process	GO:0032024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032024
GO_process	GO:0032119	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032119
GO_process	GO:0034341	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034341
GO_process	GO:0060627	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060627
GO_process	GO:0061088	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061088
GO_process	GO:0070555	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070555
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
Gene3D	1.20.1510.10	http://www.cathdb.info/version/latest/superfamily/1.20.1510.10
GeneCards	SLC30A8	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC30A8
GeneID	169026	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=169026
GeneTree	ENSGT00550000074381	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074381
HGNC	HGNC:20303	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20303
HOGENOM	HOG000079023	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000079023&db=HOGENOM6
HOVERGEN	HBG003345	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003345&db=HOVERGEN
InParanoid	Q8IWU4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8IWU4
IntAct	Q8IWU4	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8IWU4*
InterPro	IPR002524	http://www.ebi.ac.uk/interpro/entry/IPR002524
InterPro	IPR027469	http://www.ebi.ac.uk/interpro/entry/IPR027469
InterPro	IPR033572	http://www.ebi.ac.uk/interpro/entry/IPR033572
Jabion	169026	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=169026
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00409	http://www.genome.jp/dbget-bin/www_bget?H00409
KEGG_Gene	hsa:169026	http://www.genome.jp/dbget-bin/www_bget?hsa:169026
KEGG_Orthology	KO:K14695	http://www.genome.jp/dbget-bin/www_bget?KO:K14695
MIM	125853	http://www.ncbi.nlm.nih.gov/omim/125853
MIM	611145	http://www.ncbi.nlm.nih.gov/omim/611145
MINT	MINT-4722284	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4722284
OMA	QMESPVD	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QMESPVD
OrthoDB	EOG091G07UN	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07UN
PANTHER	PTHR11562	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11562
PANTHER	PTHR11562:SF37	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11562:SF37
PSORT	swissprot:ZNT8_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ZNT8_HUMAN
PSORT-B	swissprot:ZNT8_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ZNT8_HUMAN
PSORT2	swissprot:ZNT8_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ZNT8_HUMAN
Pfam	PF01545	http://pfam.xfam.org/family/PF01545
PharmGKB	PA134915546	http://www.pharmgkb.org/do/serve?objId=PA134915546&objCls=Gene
Phobius	swissprot:ZNT8_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ZNT8_HUMAN
PhylomeDB	Q8IWU4	http://phylomedb.org/?seqid=Q8IWU4
ProteinModelPortal	Q8IWU4	http://www.proteinmodelportal.org/query/uniprot/Q8IWU4
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15331542	http://www.ncbi.nlm.nih.gov/pubmed/15331542
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16158222	http://www.ncbi.nlm.nih.gov/pubmed/16158222
PubMed	16421571	http://www.ncbi.nlm.nih.gov/pubmed/16421571
PubMed	16984975	http://www.ncbi.nlm.nih.gov/pubmed/16984975
PubMed	17118530	http://www.ncbi.nlm.nih.gov/pubmed/17118530
PubMed	17293876	http://www.ncbi.nlm.nih.gov/pubmed/17293876
PubMed	17971500	http://www.ncbi.nlm.nih.gov/pubmed/17971500
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
Reactome	R-HSA-264876	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-264876
Reactome	R-HSA-435368	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-435368
RefSeq	NP_001166282	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001166282
RefSeq	NP_001166284	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001166284
RefSeq	NP_001166285	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001166285
RefSeq	NP_001166286	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001166286
RefSeq	NP_776250	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_776250
STRING	9606.ENSP00000415011	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000415011&targetmode=cogs
TCDB	2.A.4.3	http://www.tcdb.org/search/result.php?tc=2.A.4.3
TIGRFAMs	TIGR01297	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01297
UCSC	uc003yog	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003yog&org=rat
UniGene	Hs.532270	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.532270
UniProtKB	ZNT8_HUMAN	http://www.uniprot.org/uniprot/ZNT8_HUMAN
UniProtKB-AC	Q8IWU4	http://www.uniprot.org/uniprot/Q8IWU4
charge	swissprot:ZNT8_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ZNT8_HUMAN
eggNOG	COG1230	http://eggnogapi.embl.de/nog_data/html/tree/COG1230
eggNOG	KOG1482	http://eggnogapi.embl.de/nog_data/html/tree/KOG1482
epestfind	swissprot:ZNT8_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ZNT8_HUMAN
garnier	swissprot:ZNT8_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ZNT8_HUMAN
helixturnhelix	swissprot:ZNT8_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZNT8_HUMAN
hmoment	swissprot:ZNT8_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ZNT8_HUMAN
iep	swissprot:ZNT8_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ZNT8_HUMAN
inforesidue	swissprot:ZNT8_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ZNT8_HUMAN
neXtProt	NX_Q8IWU4	http://www.nextprot.org/db/entry/NX_Q8IWU4
octanol	swissprot:ZNT8_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ZNT8_HUMAN
pepcoil	swissprot:ZNT8_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ZNT8_HUMAN
pepdigest	swissprot:ZNT8_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ZNT8_HUMAN
pepinfo	swissprot:ZNT8_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ZNT8_HUMAN
pepnet	swissprot:ZNT8_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ZNT8_HUMAN
pepstats	swissprot:ZNT8_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ZNT8_HUMAN
pepwheel	swissprot:ZNT8_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ZNT8_HUMAN
pepwindow	swissprot:ZNT8_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ZNT8_HUMAN
sigcleave	swissprot:ZNT8_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ZNT8_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SCNBA_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9UI33-1; Sequence=Displayed; Name=2; Synonyms=Scn12a-s; IsoId=Q9UI33-2; Sequence=VSP_012260, VSP_012261; Name=3; IsoId=Q9UI33-3; Sequence=VSP_012259; Note=No experimental confirmation available.; 
# AltName	SCNBA_HUMAN	Peripheral nerve sodium channel 5
# AltName	SCNBA_HUMAN	Sensory neuron sodium channel 2
# AltName	SCNBA_HUMAN	Sodium channel protein type XI subunit alpha
# AltName	SCNBA_HUMAN	Voltage-gated sodium channel subunit alpha Nav1.9
# AltName	SCNBA_HUMAN	hNaN
# CCDS	CCDS33737	-. [Q9UI33-1]
# ChiTaRS	SCN11A	human
# DISEASE	SCNBA_HUMAN	Episodic pain syndrome, familial, 3 (FEPS3) [MIM 615552]  An autosomal dominant neurologic disorder characterized by paroxysmal pain mainly affecting the distal lower extremities and occasionally the upper body, especially the joints of fingers and arms. The pain is exacerbated with fatigue. {ECO 0000269|PubMed 24207120, ECO 0000269|PubMed 24776970, ECO 0000269|PubMed 25791876, ECO 0000269|PubMed 27224030}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCNBA_HUMAN	Neuropathy, hereditary sensory and autonomic, 7 (HSAN7) [MIM 615548]  A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN7 is characterized by congenital inability to experience pain resulting in self-mutilations, slow-healing wounds, and multiple painless fractures. mild muscle weakness, delayed motor development, slightly reduced motor and sensory nerve conduction velocities, hyperhidrosis and gastrointestinal dysfunction. {ECO 0000269|PubMed 24036948, ECO 0000269|PubMed 26645915}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	SCNBA_HUMAN	The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position. 
# DrugBank	DB00313	Valproic Acid
# DrugBank	DB00907	Cocaine
# DrugBank	DB00909	Zonisamide
# Ensembl	ENST00000302328	ENSP00000307599; ENSG00000168356. [Q9UI33-1]
# Ensembl	ENST00000444237	ENSP00000408028; ENSG00000168356. [Q9UI33-2]
# Ensembl	ENST00000456224	ENSP00000416757; ENSG00000168356. [Q9UI33-3]
# FUNCTION	SCNBA_HUMAN	This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization. {ECO 0000269|PubMed 10580103, ECO 0000269|PubMed 12384689}. 
# GO_component	GO:0001518	voltage-gated sodium channel complex; IEA:InterPro.
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0044299	C-fiber; IEA:Ensembl.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005248	voltage-gated sodium channel activity; TAS:ProtInc.
# GO_process	GO:0006814	sodium ion transport; TAS:ProtInc.
# GO_process	GO:0019228	neuronal action potential; IBA:GO_Central.
# GO_process	GO:0042493	response to drug; TAS:ProtInc.
# GO_process	GO:0051930	regulation of sensory perception of pain; ISS:UniProtKB.
# GO_process	GO:0086010	membrane depolarization during action potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.20.120.350	-; 4.
# Genevisible	Q9UI33	HS
# HGNC	HGNC:10583	SCN11A
# InterPro	IPR001696	Na_channel_asu
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR010526	Na_trans_assoc
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028821	Na_channel_a11su
# KEGG_Brite	ko04040	Ion channels
# KEGG_Disease	H01391	[Nervous system disease] Familial episodic pain syndrome (FEPS)
# MIM	604385	gene
# MIM	615548	phenotype
# MIM	615552	phenotype
# Organism	SCNBA_HUMAN	Homo sapiens (Human)
# Orphanet	306577	Sodium channelopathy-related small fiber neuropathy
# Orphanet	391392	Familial episodic pain syndrome with predominantly lower limb involvement
# Orphanet	391397	Hereditary sensory and autonomic neuropathy type 7
# Orphanet	46348	Paroxysmal extreme pain disorder
# Orphanet	88642	Channelopathy-associated congenital insensitivity to pain
# Orphanet	90026	Primary erythermalgia
# PANTHER	PTHR10037:SF210	PTHR10037:SF210; 2
# PRINTS	PR00170	NACHANNEL
# PTM	SCNBA_HUMAN	Phosphorylation at Ser-1341 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents. {ECO 0000250}. 
# Pfam	PF00520	Ion_trans; 4
# Pfam	PF06512	Na_trans_assoc
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-445095	Interaction between L1 and Ankyrins
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# RecName	SCNBA_HUMAN	Sodium channel protein type 11 subunit alpha
# RefSeq	NP_001274152	NM_001287223.1. [Q9UI33-1]
# RefSeq	NP_054858	NM_014139.2. [Q9UI33-1]
# RefSeq	XP_016861138	XM_017005649.1. [Q9UI33-1]
# RefSeq	XP_016861139	XM_017005650.1. [Q9UI33-1]
# SIMILARITY	Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.9/SCN11A subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	SCNBA_HUMAN	Cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUBUNIT	SCNBA_HUMAN	The voltage-resistant sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more auxiliary subunits SCN1B, SCN2B and SCN3B. 
# TCDB	1.A.1.10	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	SCNBA_HUMAN	Expressed in the dorsal root ganglia and trigeminal ganglia, olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine and placenta. {ECO 0000269|PubMed 10623608, ECO 0000269|PubMed 15302875}. 
# UCSC	uc003cis	human. [Q9UI33-1]
# eggNOG	ENOG410XNP6	LUCA
# eggNOG	KOG2301	Eukaryota
BLAST	swissprot:SCNBA_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SCNBA_HUMAN
COXPRESdb	11280	http://coxpresdb.jp/data/gene/11280.shtml
CleanEx	HS_SCN11A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SCN11A
DOI	10.1006/bbrc.1999.1916	http://dx.doi.org/10.1006/bbrc.1999.1916
DOI	10.1007/s12017-015-8347-9	http://dx.doi.org/10.1007/s12017-015-8347-9
DOI	10.1016/S0014-5793(99)01519-7	http://dx.doi.org/10.1016/S0014-5793(99)01519-7
DOI	10.1016/S0166-2236(02)00030-9	http://dx.doi.org/10.1016/S0166-2236(02)00030-9
DOI	10.1016/j.ajhg.2013.09.016	http://dx.doi.org/10.1016/j.ajhg.2013.09.016
DOI	10.1038/nature01085	http://dx.doi.org/10.1038/nature01085
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1038/ncomms10049	http://dx.doi.org/10.1038/ncomms10049
DOI	10.1038/ng.2767	http://dx.doi.org/10.1038/ng.2767
DOI	10.1074/jbc.M406387200	http://dx.doi.org/10.1074/jbc.M406387200
DOI	10.1093/brain/awu079	http://dx.doi.org/10.1093/brain/awu079
DOI	10.1371/journal.pone.0154827	http://dx.doi.org/10.1371/journal.pone.0154827
DrugBank	DB00313	http://www.drugbank.ca/drugs/DB00313
DrugBank	DB00907	http://www.drugbank.ca/drugs/DB00907
DrugBank	DB00909	http://www.drugbank.ca/drugs/DB00909
EMBL	AC116038	http://www.ebi.ac.uk/ena/data/view/AC116038
EMBL	AF109737	http://www.ebi.ac.uk/ena/data/view/AF109737
EMBL	AF150882	http://www.ebi.ac.uk/ena/data/view/AF150882
EMBL	AF188679	http://www.ebi.ac.uk/ena/data/view/AF188679
EMBL	AJ417790	http://www.ebi.ac.uk/ena/data/view/AJ417790
EMBL	AY686224	http://www.ebi.ac.uk/ena/data/view/AY686224
Ensembl	ENST00000302328	http://www.ensembl.org/id/ENST00000302328
Ensembl	ENST00000444237	http://www.ensembl.org/id/ENST00000444237
Ensembl	ENST00000456224	http://www.ensembl.org/id/ENST00000456224
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0001518	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001518
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0044299	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044299
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005248	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005248
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0019228	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019228
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0051930	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051930
GO_process	GO:0086010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086010
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	SCN11A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SCN11A
GeneID	11280	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11280
GeneTree	ENSGT00830000128242	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00830000128242
HGNC	HGNC:10583	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10583
HOVERGEN	HBG053100	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053100&db=HOVERGEN
HPA	HPA036746	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA036746
HPA	HPA036747	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA036747
InParanoid	Q9UI33	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UI33
IntAct	Q9UI33	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9UI33*
InterPro	IPR001696	http://www.ebi.ac.uk/interpro/entry/IPR001696
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR010526	http://www.ebi.ac.uk/interpro/entry/IPR010526
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028821	http://www.ebi.ac.uk/interpro/entry/IPR028821
Jabion	11280	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=11280
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H01391	http://www.genome.jp/dbget-bin/www_bget?H01391
KEGG_Gene	hsa:11280	http://www.genome.jp/dbget-bin/www_bget?hsa:11280
KEGG_Orthology	KO:K04843	http://www.genome.jp/dbget-bin/www_bget?KO:K04843
MIM	604385	http://www.ncbi.nlm.nih.gov/omim/604385
MIM	615548	http://www.ncbi.nlm.nih.gov/omim/615548
MIM	615552	http://www.ncbi.nlm.nih.gov/omim/615552
OMA	LENFNTA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LENFNTA
Orphanet	306577	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=306577
Orphanet	391392	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=391392
Orphanet	391397	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=391397
Orphanet	46348	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=46348
Orphanet	88642	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=88642
Orphanet	90026	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=90026
OrthoDB	EOG091G00FK	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00FK
PANTHER	PTHR10037:SF210	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10037:SF210
PRINTS	PR00170	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00170
PSORT	swissprot:SCNBA_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SCNBA_HUMAN
PSORT-B	swissprot:SCNBA_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SCNBA_HUMAN
PSORT2	swissprot:SCNBA_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SCNBA_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF06512	http://pfam.xfam.org/family/PF06512
PharmGKB	PA35001	http://www.pharmgkb.org/do/serve?objId=PA35001&objCls=Gene
Phobius	swissprot:SCNBA_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SCNBA_HUMAN
PhylomeDB	Q9UI33	http://phylomedb.org/?seqid=Q9UI33
ProteinModelPortal	Q9UI33	http://www.proteinmodelportal.org/query/uniprot/Q9UI33
PubMed	10580103	http://www.ncbi.nlm.nih.gov/pubmed/10580103
PubMed	10623608	http://www.ncbi.nlm.nih.gov/pubmed/10623608
PubMed	12384689	http://www.ncbi.nlm.nih.gov/pubmed/12384689
PubMed	12536125	http://www.ncbi.nlm.nih.gov/pubmed/12536125
PubMed	15302875	http://www.ncbi.nlm.nih.gov/pubmed/15302875
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	24036948	http://www.ncbi.nlm.nih.gov/pubmed/24036948
PubMed	24207120	http://www.ncbi.nlm.nih.gov/pubmed/24207120
PubMed	24776970	http://www.ncbi.nlm.nih.gov/pubmed/24776970
PubMed	25791876	http://www.ncbi.nlm.nih.gov/pubmed/25791876
PubMed	26645915	http://www.ncbi.nlm.nih.gov/pubmed/26645915
PubMed	27224030	http://www.ncbi.nlm.nih.gov/pubmed/27224030
Reactome	R-HSA-445095	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-445095
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
RefSeq	NP_001274152	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001274152
RefSeq	NP_054858	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_054858
RefSeq	XP_016861138	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016861138
RefSeq	XP_016861139	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016861139
STRING	9606.ENSP00000307599	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000307599&targetmode=cogs
TCDB	1.A.1.10	http://www.tcdb.org/search/result.php?tc=1.A.1.10
UCSC	uc003cis	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003cis&org=rat
UniGene	Hs.591657	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.591657
UniProtKB	SCNBA_HUMAN	http://www.uniprot.org/uniprot/SCNBA_HUMAN
UniProtKB-AC	Q9UI33	http://www.uniprot.org/uniprot/Q9UI33
charge	swissprot:SCNBA_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SCNBA_HUMAN
eggNOG	ENOG410XNP6	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNP6
eggNOG	KOG2301	http://eggnogapi.embl.de/nog_data/html/tree/KOG2301
epestfind	swissprot:SCNBA_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SCNBA_HUMAN
garnier	swissprot:SCNBA_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SCNBA_HUMAN
helixturnhelix	swissprot:SCNBA_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SCNBA_HUMAN
hmoment	swissprot:SCNBA_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SCNBA_HUMAN
iep	swissprot:SCNBA_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SCNBA_HUMAN
inforesidue	swissprot:SCNBA_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SCNBA_HUMAN
neXtProt	NX_Q9UI33	http://www.nextprot.org/db/entry/NX_Q9UI33
octanol	swissprot:SCNBA_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SCNBA_HUMAN
pepcoil	swissprot:SCNBA_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SCNBA_HUMAN
pepdigest	swissprot:SCNBA_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SCNBA_HUMAN
pepinfo	swissprot:SCNBA_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SCNBA_HUMAN
pepnet	swissprot:SCNBA_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SCNBA_HUMAN
pepstats	swissprot:SCNBA_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SCNBA_HUMAN
pepwheel	swissprot:SCNBA_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SCNBA_HUMAN
pepwindow	swissprot:SCNBA_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SCNBA_HUMAN
sigcleave	swissprot:SCNBA_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SCNBA_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	RHBG_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q9H310-1; Sequence=Displayed; Name=2; Synonyms=RhBG-2A; IsoId=Q9H310-2; Sequence=VSP_024341, VSP_024342; Note=No experimental confirmation available.; Name=3; IsoId=Q9H310-3; Sequence=VSP_024340, VSP_024343; Note=No experimental confirmation available.; Name=4; Synonyms=RhBG-1A; IsoId=Q9H310-4; Sequence=VSP_024340; Name=5; IsoId=Q9H310-5; Sequence=VSP_024340, VSP_037136; 
# AltName	RHBG_HUMAN	Rhesus blood group family type B glycoprotein
# DEVELOPMENTAL STAGE	Fetally expressed by kidney and to a lower extent in liver. {ECO:0000269|PubMed	11024028}. 
# Ensembl	ENST00000537040	ENSP00000441197; ENSG00000132677
# ExpressionAtlas	Q9H310	baseline and differential
# FUNCTION	RHBG_HUMAN	Functions as a specific ammonium transporter. {ECO 0000269|PubMed 15284342, ECO 0000269|PubMed 15929723}. 
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0014731	spectrin-associated cytoskeleton; IMP:UniProtKB.
# GO_component	GO:0016323	basolateral plasma membrane; IDA:UniProtKB.
# GO_component	GO:0030659	cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0046658	anchored component of plasma membrane; IMP:UniProtKB.
# GO_function	GO:0008519	ammonium transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0030506	ankyrin binding; IPI:UniProtKB.
# GO_process	GO:0015695	organic cation transport; IBA:GO_Central.
# GO_process	GO:0015696	ammonium transport; IDA:UniProtKB.
# GO_process	GO:0019740	nitrogen utilization; IBA:GO_Central.
# GO_process	GO:0070634	transepithelial ammonium transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005856	cytoskeleton
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0008092	cytoskeletal protein binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.10.3430.10	-; 1.
# Genevisible	Q9H310	HS
# HGNC	HGNC:14572	RHBG
# IntAct	Q9H310	2
# InterPro	IPR001905	Ammonium_transpt
# InterPro	IPR002229	RhesusRHD
# InterPro	IPR024041	NH4_transpt_AmtB-like_dom
# InterPro	IPR029020	Ammonium/urea_transptr
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Brite	ko04090	 Cellular antigens
# MIM	607079	gene
# Organism	RHBG_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11730	PTHR11730
# PRINTS	PR00342	RHESUSRHD
# PTM	RHBG_HUMAN	N-glycosylated. {ECO 0000250}. 
# Pfam	PF00909	Ammonium_transp
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-444411	Rhesus glycoproteins mediate ammonium transport
# RecName	RHBG_HUMAN	Ammonium transporter Rh type B
# RefSeq	NP_001243324	NM_001256395.1
# RefSeq	NP_001243325	NM_001256396.1
# RefSeq	NP_065140	NM_020407.4
# SEQUENCE CAUTION	RHBG_HUMAN	Sequence=AAG01086.1; Type=Frameshift; Positions=425; Evidence={ECO 0000305}; Sequence=AAL05978.1; Type=Frameshift; Positions=425; Evidence={ECO 0000305}; Sequence=AAN34363.1; Type=Frameshift; Positions=425; Evidence={ECO 0000305}; Sequence=AAN34364.1; Type=Frameshift; Positions=425; Evidence={ECO 0000305};
# SIMILARITY	Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	RHBG_HUMAN	Basolateral cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. 
# SUBUNIT	Interacts (via C-terminus) with ANK2 and ANK3; required for targeting to the basolateral membrane. {ECO:0000269|PubMed	15611082}. 
# SUPFAM	SSF111352	SSF111352
# TCDB	1.A.11.4	the ammonium transporter channel (amt) family
# TISSUE SPECIFICITY	Specifically expressed in kidney. Also detected in liver and ovary. {ECO:0000269|PubMed	11024028}. 
# UCSC	uc031vbi	human. [Q9H310-1]
# eggNOG	ENOG410XTF8	LUCA
# eggNOG	KOG3796	Eukaryota
BLAST	swissprot:RHBG_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:RHBG_HUMAN
BioCyc	ZFISH:ENSG00000132677-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000132677-MONOMER
COXPRESdb	57127	http://coxpresdb.jp/data/gene/57127.shtml
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/BJ20050657	http://dx.doi.org/10.1042/BJ20050657
DOI	10.1074/jbc.M007528200	http://dx.doi.org/10.1074/jbc.M007528200
DOI	10.1074/jbc.M413351200	http://dx.doi.org/10.1074/jbc.M413351200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1113/jphysiol.2004.067728	http://dx.doi.org/10.1113/jphysiol.2004.067728
EMBL	AF193807	http://www.ebi.ac.uk/ena/data/view/AF193807
EMBL	AF219977	http://www.ebi.ac.uk/ena/data/view/AF219977
EMBL	AF219978	http://www.ebi.ac.uk/ena/data/view/AF219978
EMBL	AF219979	http://www.ebi.ac.uk/ena/data/view/AF219979
EMBL	AF219980	http://www.ebi.ac.uk/ena/data/view/AF219980
EMBL	AK054780	http://www.ebi.ac.uk/ena/data/view/AK054780
EMBL	AK290840	http://www.ebi.ac.uk/ena/data/view/AK290840
EMBL	AL139130	http://www.ebi.ac.uk/ena/data/view/AL139130
EMBL	AL139130	http://www.ebi.ac.uk/ena/data/view/AL139130
EMBL	AL139130	http://www.ebi.ac.uk/ena/data/view/AL139130
EMBL	AL139130	http://www.ebi.ac.uk/ena/data/view/AL139130
EMBL	AL139130	http://www.ebi.ac.uk/ena/data/view/AL139130
EMBL	AL139130	http://www.ebi.ac.uk/ena/data/view/AL139130
EMBL	AL589685	http://www.ebi.ac.uk/ena/data/view/AL589685
EMBL	AL589685	http://www.ebi.ac.uk/ena/data/view/AL589685
EMBL	AL589685	http://www.ebi.ac.uk/ena/data/view/AL589685
EMBL	AL589685	http://www.ebi.ac.uk/ena/data/view/AL589685
EMBL	AL589685	http://www.ebi.ac.uk/ena/data/view/AL589685
EMBL	AL589685	http://www.ebi.ac.uk/ena/data/view/AL589685
EMBL	AY139092	http://www.ebi.ac.uk/ena/data/view/AY139092
EMBL	AY139093	http://www.ebi.ac.uk/ena/data/view/AY139093
EMBL	BC065218	http://www.ebi.ac.uk/ena/data/view/BC065218
EMBL	CH471121	http://www.ebi.ac.uk/ena/data/view/CH471121
Ensembl	ENST00000537040	http://www.ensembl.org/id/ENST00000537040
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0014731	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014731
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0030659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030659
GO_component	GO:0046658	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046658
GO_function	GO:0008519	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008519
GO_function	GO:0030506	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030506
GO_process	GO:0015695	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015695
GO_process	GO:0015696	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015696
GO_process	GO:0019740	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019740
GO_process	GO:0070634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070634
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0008092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.10.3430.10	http://www.cathdb.info/version/latest/superfamily/1.10.3430.10
GeneCards	RHBG	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=RHBG
GeneID	57127	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57127
HGNC	HGNC:14572	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14572
HOVERGEN	HBG004374	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004374&db=HOVERGEN
HPA	HPA042726	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042726
HPA	HPA048489	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA048489
InParanoid	Q9H310	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9H310
IntAct	Q9H310	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9H310*
InterPro	IPR001905	http://www.ebi.ac.uk/interpro/entry/IPR001905
InterPro	IPR002229	http://www.ebi.ac.uk/interpro/entry/IPR002229
InterPro	IPR024041	http://www.ebi.ac.uk/interpro/entry/IPR024041
InterPro	IPR029020	http://www.ebi.ac.uk/interpro/entry/IPR029020
Jabion	57127	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=57127
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Brite	ko04090	http://www.genome.jp/dbget-bin/www_bget?ko04090
KEGG_Gene	hsa:57127	http://www.genome.jp/dbget-bin/www_bget?hsa:57127
KEGG_Orthology	KO:K06580	http://www.genome.jp/dbget-bin/www_bget?KO:K06580
MIM	607079	http://www.ncbi.nlm.nih.gov/omim/607079
OrthoDB	EOG091G06KX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G06KX
PANTHER	PTHR11730	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11730
PRINTS	PR00342	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00342
PSORT	swissprot:RHBG_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:RHBG_HUMAN
PSORT-B	swissprot:RHBG_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:RHBG_HUMAN
PSORT2	swissprot:RHBG_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:RHBG_HUMAN
Pfam	PF00909	http://pfam.xfam.org/family/PF00909
PharmGKB	PA34385	http://www.pharmgkb.org/do/serve?objId=PA34385&objCls=Gene
Phobius	swissprot:RHBG_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:RHBG_HUMAN
PhylomeDB	Q9H310	http://phylomedb.org/?seqid=Q9H310
ProteinModelPortal	Q9H310	http://www.proteinmodelportal.org/query/uniprot/Q9H310
PubMed	11024028	http://www.ncbi.nlm.nih.gov/pubmed/11024028
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15284342	http://www.ncbi.nlm.nih.gov/pubmed/15284342
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15611082	http://www.ncbi.nlm.nih.gov/pubmed/15611082
PubMed	15929723	http://www.ncbi.nlm.nih.gov/pubmed/15929723
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
Reactome	R-HSA-444411	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-444411
RefSeq	NP_001243324	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243324
RefSeq	NP_001243325	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243325
RefSeq	NP_065140	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_065140
STRING	9606.ENSP00000357229	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000357229&targetmode=cogs
SUPFAM	SSF111352	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF111352
TCDB	1.A.11.4	http://www.tcdb.org/search/result.php?tc=1.A.11.4
UCSC	uc031vbi	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc031vbi&org=rat
UniGene	Hs.131835	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.131835
UniProtKB	RHBG_HUMAN	http://www.uniprot.org/uniprot/RHBG_HUMAN
UniProtKB-AC	Q9H310	http://www.uniprot.org/uniprot/Q9H310
charge	swissprot:RHBG_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:RHBG_HUMAN
eggNOG	ENOG410XTF8	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XTF8
eggNOG	KOG3796	http://eggnogapi.embl.de/nog_data/html/tree/KOG3796
epestfind	swissprot:RHBG_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:RHBG_HUMAN
garnier	swissprot:RHBG_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:RHBG_HUMAN
helixturnhelix	swissprot:RHBG_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:RHBG_HUMAN
hmoment	swissprot:RHBG_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:RHBG_HUMAN
iep	swissprot:RHBG_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:RHBG_HUMAN
inforesidue	swissprot:RHBG_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:RHBG_HUMAN
neXtProt	NX_Q9H310	http://www.nextprot.org/db/entry/NX_Q9H310
octanol	swissprot:RHBG_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:RHBG_HUMAN
pepcoil	swissprot:RHBG_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:RHBG_HUMAN
pepdigest	swissprot:RHBG_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:RHBG_HUMAN
pepinfo	swissprot:RHBG_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:RHBG_HUMAN
pepnet	swissprot:RHBG_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:RHBG_HUMAN
pepstats	swissprot:RHBG_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:RHBG_HUMAN
pepwheel	swissprot:RHBG_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:RHBG_HUMAN
pepwindow	swissprot:RHBG_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:RHBG_HUMAN
sigcleave	swissprot:RHBG_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:RHBG_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	107252	397
# BioGrid	107256	38
# BioGrid	107259	32
# CDD	cd00051	EFh; 2
# ChiTaRS	CALM1	human
# ChiTaRS	CALM3	human
# DISEASE	CALM_HUMAN	Long QT syndrome 14 (LQT14) [MIM 616247]  A form of long QT syndrome, a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. {ECO 0000269|PubMed 23388215, ECO 0000269|PubMed 24076290}. Note=The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14. 
# DISEASE	CALM_HUMAN	Long QT syndrome 15 (LQT15) [MIM 616249]  A form of long QT syndrome, a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. {ECO 0000269|PubMed 23388215, ECO 0000269|PubMed 24917665}. Note=The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM2 are the cause of LQT15. 
# DISEASE	CALM_HUMAN	Ventricular tachycardia, catecholaminergic polymorphic, 4 (CPVT4) [MIM 614916]  An arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical activity or emotional stress. {ECO 0000269|PubMed 23040497}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00477	Chlorpromazine
# DrugBank	DB00527	Cinchocaine
# DrugBank	DB00622	Nicardipine
# DrugBank	DB00623	Fluphenazine
# DrugBank	DB00753	Isoflurane
# DrugBank	DB00831	Trifluoperazine
# DrugBank	DB00836	Loperamide
# DrugBank	DB00850	Perphenazine
# DrugBank	DB00925	Phenoxybenzamine
# DrugBank	DB01023	Felodipine
# DrugBank	DB01065	Melatonin
# DrugBank	DB01069	Promethazine
# DrugBank	DB01100	Pimozide
# DrugBank	DB01115	Nifedipine
# DrugBank	DB01244	Bepridil
# DrugBank	DB01429	Aprindine
# DrugBank	DB04841	Flunarizine
# Ensembl	ENST00000272298	ENSP00000272298; ENSG00000143933
# Ensembl	ENST00000291295	ENSP00000291295; ENSG00000160014
# Ensembl	ENST00000356978	ENSP00000349467; ENSG00000198668
# Ensembl	ENST00000596362	ENSP00000472141; ENSG00000160014
# ExpressionAtlas	P62158	baseline and differential
# FUNCTION	CALM_HUMAN	Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. {ECO 0000269|PubMed 16760425, ECO 0000269|PubMed 23893133}. 
# GO_component	GO:0000922	spindle pole; IDA:UniProtKB.
# GO_component	GO:0005576	extracellular region; TAS:Reactome.
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005654	nucleoplasm; TAS:Reactome.
# GO_component	GO:0005737	cytoplasm; TAS:UniProtKB.
# GO_component	GO:0005813	centrosome; IDA:UniProtKB.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0005876	spindle microtubule; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; TAS:UniProtKB.
# GO_component	GO:0030017	sarcomere; IDA:BHF-UCL.
# GO_component	GO:0031982	vesicle; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005088	Ras guanyl-nucleotide exchange factor activity; TAS:Reactome.
# GO_function	GO:0005509	calcium ion binding; IDA:BHF-UCL.
# GO_function	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity; TAS:Reactome.
# GO_function	GO:0015276	ligand-gated ion channel activity; TAS:Reactome.
# GO_function	GO:0019901	protein kinase binding; IPI:BHF-UCL.
# GO_function	GO:0019904	protein domain specific binding; IPI:UniProtKB.
# GO_function	GO:0031432	titin binding; IPI:BHF-UCL.
# GO_function	GO:0031996	thioesterase binding; IPI:UniProtKB.
# GO_function	GO:0031997	N-terminal myristoylation domain binding; IPI:UniProtKB.
# GO_function	GO:0043274	phospholipase binding; IPI:BHF-UCL.
# GO_function	GO:0043539	protein serine/threonine kinase activator activity; TAS:BHF-UCL.
# GO_function	GO:0044325	ion channel binding; IPI:BHF-UCL.
# GO_function	GO:0072542	protein phosphatase activator activity; IDA:BHF-UCL.
# GO_process	GO:0000165	MAPK cascade; TAS:Reactome.
# GO_process	GO:0002027	regulation of heart rate; IMP:BHF-UCL.
# GO_process	GO:0002576	platelet degranulation; TAS:Reactome.
# GO_process	GO:0005513	detection of calcium ion; IMP:BHF-UCL.
# GO_process	GO:0005980	glycogen catabolic process; TAS:Reactome.
# GO_process	GO:0006936	muscle contraction; TAS:Reactome.
# GO_process	GO:0007186	G-protein coupled receptor signaling pathway; TAS:UniProtKB.
# GO_process	GO:0007223	Wnt signaling pathway, calcium modulating pathway; TAS:Reactome.
# GO_process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation; TAS:BHF-UCL.
# GO_process	GO:0010801	negative regulation of peptidyl-threonine phosphorylation; TAS:BHF-UCL.
# GO_process	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IDA:BHF-UCL.
# GO_process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; IC:BHF-UCL.
# GO_process	GO:0021762	substantia nigra development; IEP:UniProtKB.
# GO_process	GO:0022400	regulation of rhodopsin mediated signaling pathway; TAS:Reactome.
# GO_process	GO:0030801	positive regulation of cyclic nucleotide metabolic process; IDA:BHF-UCL.
# GO_process	GO:0031954	positive regulation of protein autophosphorylation; TAS:BHF-UCL.
# GO_process	GO:0032465	regulation of cytokinesis; IMP:UniProtKB.
# GO_process	GO:0032516	positive regulation of phosphoprotein phosphatase activity; IDA:BHF-UCL.
# GO_process	GO:0035307	positive regulation of protein dephosphorylation; IDA:BHF-UCL.
# GO_process	GO:0038095	Fc-epsilon receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0043647	inositol phosphate metabolic process; TAS:Reactome.
# GO_process	GO:0050999	regulation of nitric-oxide synthase activity; TAS:Reactome.
# GO_process	GO:0051343	positive regulation of cyclic-nucleotide phosphodiesterase activity; IDA:BHF-UCL.
# GO_process	GO:0051592	response to calcium ion; IDA:BHF-UCL.
# GO_process	GO:0055117	regulation of cardiac muscle contraction; IMP:BHF-UCL.
# GO_process	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity; ISS:BHF-UCL.
# GO_process	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity; IDA:BHF-UCL.
# GO_process	GO:0071902	positive regulation of protein serine/threonine kinase activity; TAS:BHF-UCL.
# GO_process	GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction; IC:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005576	extracellular region
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005815	microtubule organizing center
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008092	cytoskeletal protein binding
# GOslim_function	GO:0016301	kinase activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0030234	enzyme regulator activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0005975	carbohydrate metabolic process
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009056	catabolic process
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0048856	anatomical structure development
# Gene3D	1.10.238.10	-; 2.
# Genevisible	P62158	HS
# HGNC	HGNC:1442	CALM1
# HGNC	HGNC:1445	CALM2
# HGNC	HGNC:1449	CALM3
# INTERACTION	CALM_HUMAN	Q9Z305 - (xeno); NbExp=2; IntAct=EBI-397435, EBI-9084208; P29274 ADORA2A; NbExp=3; IntAct=EBI-397435, EBI-2902702; P49407 ARRB1; NbExp=3; IntAct=EBI-397435, EBI-743313; P32121 ARRB2; NbExp=3; IntAct=EBI-397435, EBI-714559; Q8NCR3 C11orf65; NbExp=9; IntAct=EBI-397435, EBI-744790; Q13936 CACNA1C; NbExp=12; IntAct=EBI-397435, EBI-1038838; O43303 CCP110; NbExp=14; IntAct=EBI-397435, EBI-1566217; O15078 CEP290; NbExp=5; IntAct=EBI-397435, EBI-1811944; P40136 cya (xeno); NbExp=8; IntAct=EBI-397435, EBI-457011; P53355 DAPK1; NbExp=6; IntAct=EBI-397435, EBI-358616; P00533 EGFR; NbExp=4; IntAct=EBI-397435, EBI-297353; P25445 FAS; NbExp=4; IntAct=EBI-397435, EBI-494743; Q15051 IQCB1; NbExp=7; IntAct=EBI-397435, EBI-2805823; Q15051-2 IQCB1; NbExp=5; IntAct=EBI-397435, EBI-11944935; O95259 KCNH1; NbExp=4; IntAct=EBI-397435, EBI-2909270; O95259-2 KCNH1; NbExp=8; IntAct=EBI-397435, EBI-9836801; A0A087WXN0 KIAA1683; NbExp=6; IntAct=EBI-397435, EBI-12150263; A0JP07 KIAA1683; NbExp=3; IntAct=EBI-397435, EBI-10171456; Q9H0B3 KIAA1683; NbExp=4; IntAct=EBI-397435, EBI-745878; P26645 Marcks (xeno); NbExp=2; IntAct=EBI-397435, EBI-911805; Q9HD67 MYO10; NbExp=2; IntAct=EBI-397435, EBI-307061; Q96PM5 RCHY1; NbExp=2; IntAct=EBI-397435, EBI-947779; Q14524 SCN5A; NbExp=2; IntAct=EBI-397435, EBI-726858; Q86TI0 TBC1D1; NbExp=4; IntAct=EBI-397435, EBI-1644036; Q8WZ42 TTN; NbExp=2; IntAct=EBI-397435, EBI-681210; P63104 YWHAZ; NbExp=2; IntAct=EBI-397435, EBI-347088; 
# IntAct	P62158	241
# InterPro	IPR002048	EF_hand_dom
# InterPro	IPR011992	EF-hand-dom_pair
# InterPro	IPR018247	EF_Hand_1_Ca_BS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko03036	 Chromosome
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04070	Phosphatidylinositol signaling system
# KEGG_Pathway	ko04114	Oocyte meiosis
# KEGG_Pathway	ko04270	Vascular smooth muscle contraction
# KEGG_Pathway	ko04626	Plant-pathogen interaction
# KEGG_Pathway	ko04713	Circadian entrainment
# KEGG_Pathway	ko04720	Long-term potentiation
# KEGG_Pathway	ko04722	Neurotrophin signaling pathway
# KEGG_Pathway	ko04728	Dopaminergic synapse
# KEGG_Pathway	ko04740	Olfactory transduction
# KEGG_Pathway	ko04744	Phototransduction
# KEGG_Pathway	ko04745	Phototransduction - fly
# KEGG_Pathway	ko04910	Insulin signaling pathway
# KEGG_Pathway	ko04912	GnRH signaling pathway
# KEGG_Pathway	ko04916	Melanogenesis
# KEGG_Pathway	ko04970	Salivary secretion
# KEGG_Pathway	ko04971	Gastric acid secretion
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05031	Amphetamine addiction
# KEGG_Pathway	ko05034	Alcoholism
# KEGG_Pathway	ko05133	Pertussis
# KEGG_Pathway	ko05152	Tuberculosis
# KEGG_Pathway	ko05214	Glioma
# MIM	114180	gene
# MIM	114182	gene
# MIM	114183	gene
# MIM	614916	phenotype
# MIM	616247	phenotype
# MIM	616249	phenotype
# MISCELLANEOUS	CALM_HUMAN	This protein has four functional calcium-binding sites. 
# Organism	CALM_HUMAN	Homo sapiens (Human)
# Orphanet	3286	Catecholaminergic polymorphic ventricular tachycardia
# PDB	1AJI	Model; -; A=5-148
# PDB	1CDL	X-ray; 2.00 A; A/B/C/D=2-148
# PDB	1CLL	X-ray; 1.70 A; A=2-149
# PDB	1CTR	X-ray; 2.45 A; A=2-149
# PDB	1IWQ	X-ray; 2.00 A; A=2-149
# PDB	1J7O	NMR; -; A=2-77
# PDB	1J7P	NMR; -; A=83-149
# PDB	1K90	X-ray; 2.75 A; D/E/F=2-149
# PDB	1K93	X-ray; 2.95 A; D/E/F=6-149
# PDB	1L7Z	X-ray; 2.30 A; A=2-149
# PDB	1LVC	X-ray; 3.60 A; D/E/F=1-149
# PDB	1NKF	NMR; -; A=99-105
# PDB	1PK0	X-ray; 3.30 A; D/E/F=2-148
# PDB	1S26	X-ray; 3.00 A; D/E/F=2-149
# PDB	1SK6	X-ray; 3.20 A; D/E/F=2-149
# PDB	1SW8	NMR; -; A=2-80
# PDB	1WRZ	X-ray; 2.00 A; A=1-149
# PDB	1XFU	X-ray; 3.35 A; O/P/Q/R/S/T=1-149
# PDB	1XFV	X-ray; 3.35 A; O/P/Q/R/S/T=1-149
# PDB	1XFW	X-ray; 3.40 A; O/P/Q/R/S/T=1-149
# PDB	1XFX	X-ray; 3.20 A; O/P/Q/R/S/T=1-149
# PDB	1XFY	X-ray; 3.30 A; O/P/Q/R/S/T=1-149
# PDB	1XFZ	X-ray; 3.25 A; O/P/Q/R/S/T=1-149
# PDB	1Y6W	X-ray; 2.40 A; A=2-149
# PDB	1YR5	X-ray; 1.70 A; A=2-149
# PDB	1YRT	X-ray; 2.10 A; B=76-149
# PDB	1YRU	X-ray; 2.50 A; B=76-149
# PDB	1ZOT	X-ray; 2.20 A; B=80-148
# PDB	1ZUZ	X-ray; 1.91 A; A=1-149
# PDB	2BE6	X-ray; 2.00 A; A/B/C=1-149
# PDB	2F3Y	X-ray; 1.45 A; A=2-149
# PDB	2F3Z	X-ray; 1.60 A; A=2-149
# PDB	2HF5	NMR; -; A=47-114
# PDB	2I08	X-ray; 2.00 A; A=3-79
# PDB	2JZI	NMR; -; A=2-149
# PDB	2K0E	NMR; -; A=2-149
# PDB	2K0F	NMR; -; A=2-149
# PDB	2K0J	NMR; -; A=3-149
# PDB	2K61	NMR; -; A=2-149
# PDB	2KNE	NMR; -; A=2-149
# PDB	2KUG	NMR; -; A=2-77
# PDB	2KUH	NMR; -; A=83-149
# PDB	2L53	NMR; -; A=2-149
# PDB	2L7L	NMR; -; A=2-149
# PDB	2LGF	NMR; -; A=3-149
# PDB	2LL6	NMR; -; A=2-149
# PDB	2LL7	NMR; -; A=2-149
# PDB	2LQC	NMR; -; A=2-78
# PDB	2LQP	NMR; -; A=79-149
# PDB	2LV6	Other; -; A=2-149
# PDB	2M0J	NMR; -; A=2-149
# PDB	2M0K	NMR; -; A=2-149
# PDB	2M55	NMR; -; A=2-149
# PDB	2MG5	NMR; -; A=2-149
# PDB	2N27	NMR; -; A=2-149
# PDB	2N6A	NMR; -; A=6-147
# PDB	2N8J	NMR; -; A=2-149
# PDB	2R28	X-ray; 1.86 A; A/B=1-149
# PDB	2V01	X-ray; 2.15 A; A=2-149
# PDB	2V02	X-ray; 2.20 A; A=2-149
# PDB	2VAY	X-ray; 1.94 A; A=4-149
# PDB	2W73	X-ray; 1.45 A; A/B/E/F=1-149
# PDB	2WEL	X-ray; 1.90 A; D=1-149
# PDB	2X0G	X-ray; 2.20 A; B=2-149
# PDB	2Y4V	X-ray; 1.80 A; A=1-149
# PDB	3BYA	X-ray; 1.85 A; A=2-149
# PDB	3DVE	X-ray; 2.35 A; A=2-149
# PDB	3DVJ	X-ray; 2.80 A; A=2-149
# PDB	3DVK	X-ray; 2.30 A; A=2-149
# PDB	3DVM	X-ray; 2.60 A; A=2-149
# PDB	3EWT	X-ray; 2.40 A; A=2-149
# PDB	3EWV	X-ray; 2.60 A; A=2-149
# PDB	3G43	X-ray; 2.10 A; A/B/C/D=2-149
# PDB	3HR4	X-ray; 2.50 A; B/D/F/H=1-149
# PDB	3J41	EM; 25.0 A; E/F=1-149
# PDB	3O77	X-ray; 2.35 A; A=1-149
# PDB	3O78	X-ray; 2.60 A; A/B=1-149
# PDB	3OXQ	X-ray; 2.55 A; A/B/C/D=1-149
# PDB	3SUI	X-ray; 1.95 A; A=1-149
# PDB	3UCT	X-ray; 1.90 A; A/B=2-80
# PDB	3UCW	X-ray; 1.76 A; A/B/C/D=2-80
# PDB	3UCY	X-ray; 1.80 A; A=2-80
# PDB	4BW7	X-ray; 1.81 A; A/C=1-149
# PDB	4BW8	X-ray; 1.80 A; A/B=1-149
# PDB	4BYF	X-ray; 2.74 A; B/D=1-149
# PDB	4DCK	X-ray; 2.20 A; B=1-149
# PDB	4DJC	X-ray; 1.35 A; A=1-149
# PDB	4GOW	X-ray; 2.60 A; D=4-147
# PDB	4JPZ	X-ray; 3.02 A; C/I=1-149
# PDB	4JQ0	X-ray; 3.84 A; C=1-149
# PDB	4L79	X-ray; 2.30 A; B=1-149
# PDB	4LZX	X-ray; 1.50 A; A=2-149
# PDB	4M1L	X-ray; 2.10 A; A=2-149
# PDB	4OVN	X-ray; 2.80 A; A/B/C/D/E=1-149
# PDB	4Q57	X-ray; 1.80 A; A=10-74
# PDB	4Q5U	X-ray; 1.95 A; A=1-149
# PDB	4UMO	X-ray; 3.00 A; C/D=1-149
# PDB	4UPU	X-ray; 2.34 A; A=2-149
# PDB	4V0C	X-ray; 2.86 A; C/D=1-149
# PDB	5COC	X-ray; 2.67 A; A=5-78
# PDB	5DOW	X-ray; 1.70 A; A/C/E/G=2-149
# PDB	5GGM	NMR; -; A=2-149
# PDB	5I0I	X-ray; 3.15 A; C/E=3-147, G=84-126, I=84-147
# PDB	5J03	X-ray; 2.00 A; B=1-149
# PDB	5J8H	NMR; -; A=2-149
# PDB	5K7L	EM; 3.78 A; B=1-149
# PDB	5K8Q	X-ray; 1.74 A; A=1-149
# PIR	S48728	MCHU
# PROSITE	PS00018	EF_HAND_1; 4
# PROSITE	PS50222	EF_HAND_2; 4
# PTM	CALM_HUMAN	Phosphorylation results in a decreased activity. {ECO 0000250}. 
# PTM	CALM_HUMAN	Ubiquitination results in a strongly decreased activity. {ECO 0000250}. 
# Pfam	PF13499	EF-hand_7; 2
# Proteomes	UP000005640	Chromosome 14
# Proteomes	UP000005640	Chromosome 19
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-111932	CaMK IV-mediated phosphorylation of CREB
# Reactome	R-HSA-111933	Calmodulin induced events
# Reactome	R-HSA-111957	Cam-PDE 1 activation
# Reactome	R-HSA-111997	CaM pathway
# Reactome	R-HSA-114608	Platelet degranulation
# Reactome	R-HSA-1445148	Translocation of GLUT4 to the plasma membrane
# Reactome	R-HSA-1474151	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
# Reactome	R-HSA-163615	PKA activation
# Reactome	R-HSA-180024	DARPP-32 events
# Reactome	R-HSA-1855204	Synthesis of IP3 and IP4 in the cytosol
# Reactome	R-HSA-203615	eNOS activation
# Reactome	R-HSA-2514859	Inactivation, recovery and regulation of the phototransduction cascade
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# Reactome	R-HSA-2871809	FCERI mediated Ca+2 mobilization
# Reactome	R-HSA-4086398	Ca2+ pathway
# Reactome	R-HSA-418359	Reduction of cytosolic Ca++ levels
# Reactome	R-HSA-425561	Sodium/Calcium exchangers
# Reactome	R-HSA-442717	CREB phosphorylation through the activation of CaMKK
# Reactome	R-HSA-442729	CREB phosphorylation through the activation of CaMKII
# Reactome	R-HSA-442745	Activation of CaMK IV
# Reactome	R-HSA-442982	Ras activation uopn Ca2+ infux through NMDA receptor
# Reactome	R-HSA-445355	Smooth Muscle Contraction
# Reactome	R-HSA-451308	Activation of Ca-permeable Kainate Receptor
# Reactome	R-HSA-5210891	Uptake and function of anthrax toxins
# Reactome	R-HSA-5218920	VEGFR2 mediated vascular permeability
# Reactome	R-HSA-5218921	VEGFR2 mediated cell proliferation
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# Reactome	R-HSA-5578775	Ion homeostasis
# Reactome	R-HSA-5607763	CLEC7A (Dectin-1) induces NFAT activation
# Reactome	R-HSA-5626467	RHO GTPases activate IQGAPs
# Reactome	R-HSA-5627123	RHO GTPases activate PAKs
# Reactome	R-HSA-5673001	RAF/MAP kinase cascade
# Reactome	R-HSA-70221	Glycogen breakdown (glycogenolysis)
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# Reactome	R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
# RecName	CALM_HUMAN	Calmodulin
# RefSeq	NP_001292553	NM_001305624.1
# RefSeq	NP_001292554	NM_001305625.1
# RefSeq	NP_001292555	NM_001305626.1
# RefSeq	NP_001316851	NM_001329922.1
# RefSeq	NP_001316852	NM_001329923.1
# RefSeq	NP_001316853	NM_001329924.1
# RefSeq	NP_001316854	NM_001329925.1
# RefSeq	NP_001316855	NM_001329926.1
# RefSeq	NP_001734	NM_001743.5
# RefSeq	NP_005175	NM_005184.3
# RefSeq	NP_008819	NM_006888.4
# SEQUENCE CAUTION	Sequence=CAA36839.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the calmodulin family. {ECO	0000305}. 
# SIMILARITY	Contains 4 EF-hand domains. {ECO:0000255|PROSITE- ProRule	PRU00448}. 
# SMART	SM00054	EFh; 4
# SUBCELLULAR LOCATION	CALM_HUMAN	Cytoplasm, cytoskeleton, spindle {ECO 0000269|PubMed 16760425}. Cytoplasm, cytoskeleton, spindle pole {ECO 0000269|PubMed 16760425}. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules. 
# SUBUNIT	CALM_HUMAN	Interacts with MYO1C, MYO5A and RRAD. Interacts with MYO10 (By similarity). Interacts with CEP97, CCP110, TTN/titin and SRY (PubMed 9804419, PubMed 12871148, PubMed 15746192, PubMed 16760425, PubMed 17719545). Interacts with USP6; the interaction is calcium dependent (PubMed 16127172). Interacts with CDK5RAP2 (PubMed 20466722). Interacts with SCN5A (PubMed 21167176). Interacts with RYR1 and RYR2 (PubMed 18650434). Interacts with FCHO1 (PubMed 22484487). Interacts with MIP in a 1 2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure (PubMed 23893133). Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport (By similarity). Interacts with IQCF1 (By similarity). Interacts with SYT7 (By similarity). Interacts with CEACAM1 (via cytoplasmic domain); this interaction is in a calcium dependent manner and reduces homophilic cell adhesion through dissociation of dimer (By similarity). {ECO 0000250|UniProtKB P62157, ECO 0000250|UniProtKB P62161, ECO 0000250|UniProtKB P62204, ECO 0000269|PubMed 12485993, ECO 0000269|PubMed 12577052, ECO 0000269|PubMed 12871148, ECO 0000269|PubMed 15719022, ECO 0000269|PubMed 15746192, ECO 0000269|PubMed 16127172, ECO 0000269|PubMed 16299511, ECO 0000269|PubMed 16760425, ECO 0000269|PubMed 17719545, ECO 0000269|PubMed 18650434, ECO 0000269|PubMed 20466722, ECO 0000269|PubMed 21167176, ECO 0000269|PubMed 22484487, ECO 0000269|PubMed 23109337, ECO 0000269|PubMed 23893133, ECO 0000269|PubMed 9804419}. 
# SUPFAM	SSF47473	SSF47473
# TCDB	8.A.82.1	the calmodulin calcium binding protein (calmodulin) family
# UCSC	uc001xyl	human
# WEB RESOURCE	CALM_HUMAN	Name=Protein Spotlight; Note=A question of length - Issue 105 of May 2009; URL="http //web.expasy.org/spotlight/back_issues/105";
# eggNOG	COG5126	LUCA
# eggNOG	KOG0027	Eukaryota
BLAST	swissprot:CALM_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CALM_HUMAN
BioCyc	MetaCyc:ENSG00000143933-MONOMER	http://biocyc.org/getid?id=MetaCyc:ENSG00000143933-MONOMER
BioCyc	ZFISH:ENSG00000143933-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000143933-MONOMER
COXPRESdb	801	http://coxpresdb.jp/data/gene/801.shtml
COXPRESdb	805	http://coxpresdb.jp/data/gene/805.shtml
COXPRESdb	808	http://coxpresdb.jp/data/gene/808.shtml
CleanEx	HS_CALM1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CALM1
CleanEx	HS_CALM2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CALM2
DIP	DIP-31794N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31794N
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/0022-2836(92)90324-D	http://dx.doi.org/10.1016/0022-2836(92)90324-D
DOI	10.1016/0167-4781(90)90203-E	http://dx.doi.org/10.1016/0167-4781(90)90203-E
DOI	10.1016/S0143-4160(98)90028-8	http://dx.doi.org/10.1016/S0143-4160(98)90028-8
DOI	10.1016/j.ajhg.2012.08.015	http://dx.doi.org/10.1016/j.ajhg.2012.08.015
DOI	10.1016/j.cell.2007.06.027	http://dx.doi.org/10.1016/j.cell.2007.06.027
DOI	10.1016/j.jacc.2013.07.091	http://dx.doi.org/10.1016/j.jacc.2013.07.091
DOI	10.1016/j.jmb.2010.11.046	http://dx.doi.org/10.1016/j.jmb.2010.11.046
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/bi00255a006	http://dx.doi.org/10.1021/bi00255a006
DOI	10.1021/bi00539a041	http://dx.doi.org/10.1021/bi00539a041
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/27603	http://dx.doi.org/10.1038/27603
DOI	10.1038/415396a	http://dx.doi.org/10.1038/415396a
DOI	10.1038/nature01348	http://dx.doi.org/10.1038/nature01348
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/nbt1046	http://dx.doi.org/10.1038/nbt1046
DOI	10.1038/ncb2473	http://dx.doi.org/10.1038/ncb2473
DOI	10.1038/nsb1101-990	http://dx.doi.org/10.1038/nsb1101-990
DOI	10.1038/nsb900	http://dx.doi.org/10.1038/nsb900
DOI	10.1038/nsmb.2630	http://dx.doi.org/10.1038/nsmb.2630
DOI	10.1038/nsmb1027	http://dx.doi.org/10.1038/nsmb1027
DOI	10.1038/sj.emboj.7600574	http://dx.doi.org/10.1038/sj.emboj.7600574
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1073/pnas.96.3.903	http://dx.doi.org/10.1073/pnas.96.3.903
DOI	10.1074/jbc.M110.105965	http://dx.doi.org/10.1074/jbc.M110.105965
DOI	10.1074/jbc.M112.380964	http://dx.doi.org/10.1074/jbc.M112.380964
DOI	10.1074/jbc.M505220200	http://dx.doi.org/10.1074/jbc.M505220200
DOI	10.1074/jbc.M804432200	http://dx.doi.org/10.1074/jbc.M804432200
DOI	10.1074/mcp.M111.015131	http://dx.doi.org/10.1074/mcp.M111.015131
DOI	10.1074/mcp.O113.027870	http://dx.doi.org/10.1074/mcp.O113.027870
DOI	10.1091/mbc.E06-04-0371	http://dx.doi.org/10.1091/mbc.E06-04-0371
DOI	10.1093/emboj/cdf681	http://dx.doi.org/10.1093/emboj/cdf681
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1432-1033.1994.00071.x	http://dx.doi.org/10.1111/j.1432-1033.1994.00071.x
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1161/CIRCGENETICS.113.000459	http://dx.doi.org/10.1161/CIRCGENETICS.113.000459
DOI	10.1161/CIRCULATIONAHA.112.001216	http://dx.doi.org/10.1161/CIRCULATIONAHA.112.001216
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1210/me.2004-0334	http://dx.doi.org/10.1210/me.2004-0334
DOI	10.2174/0929866033479004	http://dx.doi.org/10.2174/0929866033479004
DrugBank	DB00477	http://www.drugbank.ca/drugs/DB00477
DrugBank	DB00527	http://www.drugbank.ca/drugs/DB00527
DrugBank	DB00622	http://www.drugbank.ca/drugs/DB00622
DrugBank	DB00623	http://www.drugbank.ca/drugs/DB00623
DrugBank	DB00753	http://www.drugbank.ca/drugs/DB00753
DrugBank	DB00831	http://www.drugbank.ca/drugs/DB00831
DrugBank	DB00836	http://www.drugbank.ca/drugs/DB00836
DrugBank	DB00850	http://www.drugbank.ca/drugs/DB00850
DrugBank	DB00925	http://www.drugbank.ca/drugs/DB00925
DrugBank	DB01023	http://www.drugbank.ca/drugs/DB01023
DrugBank	DB01065	http://www.drugbank.ca/drugs/DB01065
DrugBank	DB01069	http://www.drugbank.ca/drugs/DB01069
DrugBank	DB01100	http://www.drugbank.ca/drugs/DB01100
DrugBank	DB01115	http://www.drugbank.ca/drugs/DB01115
DrugBank	DB01244	http://www.drugbank.ca/drugs/DB01244
DrugBank	DB01429	http://www.drugbank.ca/drugs/DB01429
DrugBank	DB04841	http://www.drugbank.ca/drugs/DB04841
EMBL	AC006536	http://www.ebi.ac.uk/ena/data/view/AC006536
EMBL	AC073283	http://www.ebi.ac.uk/ena/data/view/AC073283
EMBL	BC000454	http://www.ebi.ac.uk/ena/data/view/BC000454
EMBL	BC003354	http://www.ebi.ac.uk/ena/data/view/BC003354
EMBL	BC005137	http://www.ebi.ac.uk/ena/data/view/BC005137
EMBL	BC006464	http://www.ebi.ac.uk/ena/data/view/BC006464
EMBL	BC008437	http://www.ebi.ac.uk/ena/data/view/BC008437
EMBL	BC008597	http://www.ebi.ac.uk/ena/data/view/BC008597
EMBL	BC011834	http://www.ebi.ac.uk/ena/data/view/BC011834
EMBL	BC017385	http://www.ebi.ac.uk/ena/data/view/BC017385
EMBL	BC018677	http://www.ebi.ac.uk/ena/data/view/BC018677
EMBL	BC026065	http://www.ebi.ac.uk/ena/data/view/BC026065
EMBL	BC047523	http://www.ebi.ac.uk/ena/data/view/BC047523
EMBL	BT006818	http://www.ebi.ac.uk/ena/data/view/BT006818
EMBL	BT006855	http://www.ebi.ac.uk/ena/data/view/BT006855
EMBL	BT009916	http://www.ebi.ac.uk/ena/data/view/BT009916
EMBL	CR541990	http://www.ebi.ac.uk/ena/data/view/CR541990
EMBL	CR542021	http://www.ebi.ac.uk/ena/data/view/CR542021
EMBL	D45887	http://www.ebi.ac.uk/ena/data/view/D45887
EMBL	J04046	http://www.ebi.ac.uk/ena/data/view/J04046
EMBL	M19311	http://www.ebi.ac.uk/ena/data/view/M19311
EMBL	M27319	http://www.ebi.ac.uk/ena/data/view/M27319
EMBL	U11886	http://www.ebi.ac.uk/ena/data/view/U11886
EMBL	U12022	http://www.ebi.ac.uk/ena/data/view/U12022
EMBL	U94725	http://www.ebi.ac.uk/ena/data/view/U94725
EMBL	U94726	http://www.ebi.ac.uk/ena/data/view/U94726
EMBL	U94728	http://www.ebi.ac.uk/ena/data/view/U94728
EMBL	X52606	http://www.ebi.ac.uk/ena/data/view/X52606
EMBL	X52607	http://www.ebi.ac.uk/ena/data/view/X52607
EMBL	X52608	http://www.ebi.ac.uk/ena/data/view/X52608
Ensembl	ENST00000272298	http://www.ensembl.org/id/ENST00000272298
Ensembl	ENST00000291295	http://www.ensembl.org/id/ENST00000291295
Ensembl	ENST00000356978	http://www.ensembl.org/id/ENST00000356978
Ensembl	ENST00000596362	http://www.ensembl.org/id/ENST00000596362
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000922	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000922
GO_component	GO:0005576	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005813
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005876	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005876
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0030017	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030017
GO_component	GO:0031982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031982
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005088	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005088
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0008440	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008440
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_function	GO:0019901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019901
GO_function	GO:0019904	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019904
GO_function	GO:0031432	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031432
GO_function	GO:0031996	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031996
GO_function	GO:0031997	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031997
GO_function	GO:0043274	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043274
GO_function	GO:0043539	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043539
GO_function	GO:0044325	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044325
GO_function	GO:0072542	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072542
GO_process	GO:0000165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000165
GO_process	GO:0002027	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002027
GO_process	GO:0002576	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002576
GO_process	GO:0005513	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005513
GO_process	GO:0005980	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005980
GO_process	GO:0006936	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006936
GO_process	GO:0007186	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007186
GO_process	GO:0007223	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007223
GO_process	GO:0010800	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010800
GO_process	GO:0010801	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010801
GO_process	GO:0010880	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010880
GO_process	GO:0010881	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010881
GO_process	GO:0021762	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021762
GO_process	GO:0022400	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022400
GO_process	GO:0030801	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030801
GO_process	GO:0031954	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031954
GO_process	GO:0032465	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032465
GO_process	GO:0032516	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032516
GO_process	GO:0035307	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035307
GO_process	GO:0038095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0038095
GO_process	GO:0043647	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043647
GO_process	GO:0050999	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050999
GO_process	GO:0051343	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051343
GO_process	GO:0051592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051592
GO_process	GO:0055117	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055117
GO_process	GO:0060315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060315
GO_process	GO:0060316	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060316
GO_process	GO:0071902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071902
GO_process	GO:1901844	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901844
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005576	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005815	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005815
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GOslim_function	GO:0016301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0030234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
Gene3D	1.10.238.10	http://www.cathdb.info/version/latest/superfamily/1.10.238.10
GeneCards	CALM1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CALM1
GeneCards	CALM2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CALM2
GeneCards	CALM3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CALM3
GeneID	801	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=801
GeneID	805	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=805
GeneID	808	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=808
GeneTree	ENSGT00760000118901	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118901
HGNC	HGNC:1442	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1442
HGNC	HGNC:1445	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1445
HGNC	HGNC:1449	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1449
HOVERGEN	HBG012180	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG012180&db=HOVERGEN
HPA	CAB007790	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB007790
HPA	CAB018558	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB018558
HPA	HPA044999	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA044999
InParanoid	P62158	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P62158
IntAct	P62158	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P62158*
InterPro	IPR002048	http://www.ebi.ac.uk/interpro/entry/IPR002048
InterPro	IPR011992	http://www.ebi.ac.uk/interpro/entry/IPR011992
InterPro	IPR018247	http://www.ebi.ac.uk/interpro/entry/IPR018247
Jabion	801	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=801
Jabion	805	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=805
Jabion	808	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=808
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko03036	http://www.genome.jp/dbget-bin/www_bget?ko03036
KEGG_Gene	hsa:801	http://www.genome.jp/dbget-bin/www_bget?hsa:801
KEGG_Gene	hsa:805	http://www.genome.jp/dbget-bin/www_bget?hsa:805
KEGG_Gene	hsa:808	http://www.genome.jp/dbget-bin/www_bget?hsa:808
KEGG_Orthology	KO:K02183	http://www.genome.jp/dbget-bin/www_bget?KO:K02183
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04070	http://www.genome.jp/kegg-bin/show_pathway?ko04070
KEGG_Pathway	ko04114	http://www.genome.jp/kegg-bin/show_pathway?ko04114
KEGG_Pathway	ko04270	http://www.genome.jp/kegg-bin/show_pathway?ko04270
KEGG_Pathway	ko04626	http://www.genome.jp/kegg-bin/show_pathway?ko04626
KEGG_Pathway	ko04713	http://www.genome.jp/kegg-bin/show_pathway?ko04713
KEGG_Pathway	ko04720	http://www.genome.jp/kegg-bin/show_pathway?ko04720
KEGG_Pathway	ko04722	http://www.genome.jp/kegg-bin/show_pathway?ko04722
KEGG_Pathway	ko04728	http://www.genome.jp/kegg-bin/show_pathway?ko04728
KEGG_Pathway	ko04740	http://www.genome.jp/kegg-bin/show_pathway?ko04740
KEGG_Pathway	ko04744	http://www.genome.jp/kegg-bin/show_pathway?ko04744
KEGG_Pathway	ko04745	http://www.genome.jp/kegg-bin/show_pathway?ko04745
KEGG_Pathway	ko04910	http://www.genome.jp/kegg-bin/show_pathway?ko04910
KEGG_Pathway	ko04912	http://www.genome.jp/kegg-bin/show_pathway?ko04912
KEGG_Pathway	ko04916	http://www.genome.jp/kegg-bin/show_pathway?ko04916
KEGG_Pathway	ko04970	http://www.genome.jp/kegg-bin/show_pathway?ko04970
KEGG_Pathway	ko04971	http://www.genome.jp/kegg-bin/show_pathway?ko04971
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05031	http://www.genome.jp/kegg-bin/show_pathway?ko05031
KEGG_Pathway	ko05034	http://www.genome.jp/kegg-bin/show_pathway?ko05034
KEGG_Pathway	ko05133	http://www.genome.jp/kegg-bin/show_pathway?ko05133
KEGG_Pathway	ko05152	http://www.genome.jp/kegg-bin/show_pathway?ko05152
KEGG_Pathway	ko05214	http://www.genome.jp/kegg-bin/show_pathway?ko05214
MIM	114180	http://www.ncbi.nlm.nih.gov/omim/114180
MIM	114182	http://www.ncbi.nlm.nih.gov/omim/114182
MIM	114183	http://www.ncbi.nlm.nih.gov/omim/114183
MIM	614916	http://www.ncbi.nlm.nih.gov/omim/614916
MIM	616247	http://www.ncbi.nlm.nih.gov/omim/616247
MIM	616249	http://www.ncbi.nlm.nih.gov/omim/616249
MINT	MINT-4999725	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4999725
OMA	HRISGKA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HRISGKA
Orphanet	3286	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=3286
OrthoDB	EOG091G0V73	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0V73
PDB	1AJI	http://www.ebi.ac.uk/pdbe-srv/view/entry/1AJI
PDB	1CDL	http://www.ebi.ac.uk/pdbe-srv/view/entry/1CDL
PDB	1CLL	http://www.ebi.ac.uk/pdbe-srv/view/entry/1CLL
PDB	1CTR	http://www.ebi.ac.uk/pdbe-srv/view/entry/1CTR
PDB	1IWQ	http://www.ebi.ac.uk/pdbe-srv/view/entry/1IWQ
PDB	1J7O	http://www.ebi.ac.uk/pdbe-srv/view/entry/1J7O
PDB	1J7P	http://www.ebi.ac.uk/pdbe-srv/view/entry/1J7P
PDB	1K90	http://www.ebi.ac.uk/pdbe-srv/view/entry/1K90
PDB	1K93	http://www.ebi.ac.uk/pdbe-srv/view/entry/1K93
PDB	1L7Z	http://www.ebi.ac.uk/pdbe-srv/view/entry/1L7Z
PDB	1LVC	http://www.ebi.ac.uk/pdbe-srv/view/entry/1LVC
PDB	1NKF	http://www.ebi.ac.uk/pdbe-srv/view/entry/1NKF
PDB	1PK0	http://www.ebi.ac.uk/pdbe-srv/view/entry/1PK0
PDB	1S26	http://www.ebi.ac.uk/pdbe-srv/view/entry/1S26
PDB	1SK6	http://www.ebi.ac.uk/pdbe-srv/view/entry/1SK6
PDB	1SW8	http://www.ebi.ac.uk/pdbe-srv/view/entry/1SW8
PDB	1WRZ	http://www.ebi.ac.uk/pdbe-srv/view/entry/1WRZ
PDB	1XFU	http://www.ebi.ac.uk/pdbe-srv/view/entry/1XFU
PDB	1XFV	http://www.ebi.ac.uk/pdbe-srv/view/entry/1XFV
PDB	1XFW	http://www.ebi.ac.uk/pdbe-srv/view/entry/1XFW
PDB	1XFX	http://www.ebi.ac.uk/pdbe-srv/view/entry/1XFX
PDB	1XFY	http://www.ebi.ac.uk/pdbe-srv/view/entry/1XFY
PDB	1XFZ	http://www.ebi.ac.uk/pdbe-srv/view/entry/1XFZ
PDB	1Y6W	http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y6W
PDB	1YR5	http://www.ebi.ac.uk/pdbe-srv/view/entry/1YR5
PDB	1YRT	http://www.ebi.ac.uk/pdbe-srv/view/entry/1YRT
PDB	1YRU	http://www.ebi.ac.uk/pdbe-srv/view/entry/1YRU
PDB	1ZOT	http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZOT
PDB	1ZUZ	http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZUZ
PDB	2BE6	http://www.ebi.ac.uk/pdbe-srv/view/entry/2BE6
PDB	2F3Y	http://www.ebi.ac.uk/pdbe-srv/view/entry/2F3Y
PDB	2F3Z	http://www.ebi.ac.uk/pdbe-srv/view/entry/2F3Z
PDB	2HF5	http://www.ebi.ac.uk/pdbe-srv/view/entry/2HF5
PDB	2I08	http://www.ebi.ac.uk/pdbe-srv/view/entry/2I08
PDB	2JZI	http://www.ebi.ac.uk/pdbe-srv/view/entry/2JZI
PDB	2K0E	http://www.ebi.ac.uk/pdbe-srv/view/entry/2K0E
PDB	2K0F	http://www.ebi.ac.uk/pdbe-srv/view/entry/2K0F
PDB	2K0J	http://www.ebi.ac.uk/pdbe-srv/view/entry/2K0J
PDB	2K61	http://www.ebi.ac.uk/pdbe-srv/view/entry/2K61
PDB	2KNE	http://www.ebi.ac.uk/pdbe-srv/view/entry/2KNE
PDB	2KUG	http://www.ebi.ac.uk/pdbe-srv/view/entry/2KUG
PDB	2KUH	http://www.ebi.ac.uk/pdbe-srv/view/entry/2KUH
PDB	2L53	http://www.ebi.ac.uk/pdbe-srv/view/entry/2L53
PDB	2L7L	http://www.ebi.ac.uk/pdbe-srv/view/entry/2L7L
PDB	2LGF	http://www.ebi.ac.uk/pdbe-srv/view/entry/2LGF
PDB	2LL6	http://www.ebi.ac.uk/pdbe-srv/view/entry/2LL6
PDB	2LL7	http://www.ebi.ac.uk/pdbe-srv/view/entry/2LL7
PDB	2LQC	http://www.ebi.ac.uk/pdbe-srv/view/entry/2LQC
PDB	2LQP	http://www.ebi.ac.uk/pdbe-srv/view/entry/2LQP
PDB	2LV6	http://www.ebi.ac.uk/pdbe-srv/view/entry/2LV6
PDB	2M0J	http://www.ebi.ac.uk/pdbe-srv/view/entry/2M0J
PDB	2M0K	http://www.ebi.ac.uk/pdbe-srv/view/entry/2M0K
PDB	2M55	http://www.ebi.ac.uk/pdbe-srv/view/entry/2M55
PDB	2MG5	http://www.ebi.ac.uk/pdbe-srv/view/entry/2MG5
PDB	2N27	http://www.ebi.ac.uk/pdbe-srv/view/entry/2N27
PDB	2N6A	http://www.ebi.ac.uk/pdbe-srv/view/entry/2N6A
PDB	2N8J	http://www.ebi.ac.uk/pdbe-srv/view/entry/2N8J
PDB	2R28	http://www.ebi.ac.uk/pdbe-srv/view/entry/2R28
PDB	2V01	http://www.ebi.ac.uk/pdbe-srv/view/entry/2V01
PDB	2V02	http://www.ebi.ac.uk/pdbe-srv/view/entry/2V02
PDB	2VAY	http://www.ebi.ac.uk/pdbe-srv/view/entry/2VAY
PDB	2W73	http://www.ebi.ac.uk/pdbe-srv/view/entry/2W73
PDB	2WEL	http://www.ebi.ac.uk/pdbe-srv/view/entry/2WEL
PDB	2X0G	http://www.ebi.ac.uk/pdbe-srv/view/entry/2X0G
PDB	2Y4V	http://www.ebi.ac.uk/pdbe-srv/view/entry/2Y4V
PDB	3BYA	http://www.ebi.ac.uk/pdbe-srv/view/entry/3BYA
PDB	3DVE	http://www.ebi.ac.uk/pdbe-srv/view/entry/3DVE
PDB	3DVJ	http://www.ebi.ac.uk/pdbe-srv/view/entry/3DVJ
PDB	3DVK	http://www.ebi.ac.uk/pdbe-srv/view/entry/3DVK
PDB	3DVM	http://www.ebi.ac.uk/pdbe-srv/view/entry/3DVM
PDB	3EWT	http://www.ebi.ac.uk/pdbe-srv/view/entry/3EWT
PDB	3EWV	http://www.ebi.ac.uk/pdbe-srv/view/entry/3EWV
PDB	3G43	http://www.ebi.ac.uk/pdbe-srv/view/entry/3G43
PDB	3HR4	http://www.ebi.ac.uk/pdbe-srv/view/entry/3HR4
PDB	3J41	http://www.ebi.ac.uk/pdbe-srv/view/entry/3J41
PDB	3O77	http://www.ebi.ac.uk/pdbe-srv/view/entry/3O77
PDB	3O78	http://www.ebi.ac.uk/pdbe-srv/view/entry/3O78
PDB	3OXQ	http://www.ebi.ac.uk/pdbe-srv/view/entry/3OXQ
PDB	3SUI	http://www.ebi.ac.uk/pdbe-srv/view/entry/3SUI
PDB	3UCT	http://www.ebi.ac.uk/pdbe-srv/view/entry/3UCT
PDB	3UCW	http://www.ebi.ac.uk/pdbe-srv/view/entry/3UCW
PDB	3UCY	http://www.ebi.ac.uk/pdbe-srv/view/entry/3UCY
PDB	4BW7	http://www.ebi.ac.uk/pdbe-srv/view/entry/4BW7
PDB	4BW8	http://www.ebi.ac.uk/pdbe-srv/view/entry/4BW8
PDB	4BYF	http://www.ebi.ac.uk/pdbe-srv/view/entry/4BYF
PDB	4DCK	http://www.ebi.ac.uk/pdbe-srv/view/entry/4DCK
PDB	4DJC	http://www.ebi.ac.uk/pdbe-srv/view/entry/4DJC
PDB	4GOW	http://www.ebi.ac.uk/pdbe-srv/view/entry/4GOW
PDB	4JPZ	http://www.ebi.ac.uk/pdbe-srv/view/entry/4JPZ
PDB	4JQ0	http://www.ebi.ac.uk/pdbe-srv/view/entry/4JQ0
PDB	4L79	http://www.ebi.ac.uk/pdbe-srv/view/entry/4L79
PDB	4LZX	http://www.ebi.ac.uk/pdbe-srv/view/entry/4LZX
PDB	4M1L	http://www.ebi.ac.uk/pdbe-srv/view/entry/4M1L
PDB	4OVN	http://www.ebi.ac.uk/pdbe-srv/view/entry/4OVN
PDB	4Q57	http://www.ebi.ac.uk/pdbe-srv/view/entry/4Q57
PDB	4Q5U	http://www.ebi.ac.uk/pdbe-srv/view/entry/4Q5U
PDB	4UMO	http://www.ebi.ac.uk/pdbe-srv/view/entry/4UMO
PDB	4UPU	http://www.ebi.ac.uk/pdbe-srv/view/entry/4UPU
PDB	4V0C	http://www.ebi.ac.uk/pdbe-srv/view/entry/4V0C
PDB	5COC	http://www.ebi.ac.uk/pdbe-srv/view/entry/5COC
PDB	5DOW	http://www.ebi.ac.uk/pdbe-srv/view/entry/5DOW
PDB	5GGM	http://www.ebi.ac.uk/pdbe-srv/view/entry/5GGM
PDB	5I0I	http://www.ebi.ac.uk/pdbe-srv/view/entry/5I0I
PDB	5J03	http://www.ebi.ac.uk/pdbe-srv/view/entry/5J03
PDB	5J8H	http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8H
PDB	5K7L	http://www.ebi.ac.uk/pdbe-srv/view/entry/5K7L
PDB	5K8Q	http://www.ebi.ac.uk/pdbe-srv/view/entry/5K8Q
PDBsum	1AJI	http://www.ebi.ac.uk/pdbsum/1AJI
PDBsum	1CDL	http://www.ebi.ac.uk/pdbsum/1CDL
PDBsum	1CLL	http://www.ebi.ac.uk/pdbsum/1CLL
PDBsum	1CTR	http://www.ebi.ac.uk/pdbsum/1CTR
PDBsum	1IWQ	http://www.ebi.ac.uk/pdbsum/1IWQ
PDBsum	1J7O	http://www.ebi.ac.uk/pdbsum/1J7O
PDBsum	1J7P	http://www.ebi.ac.uk/pdbsum/1J7P
PDBsum	1K90	http://www.ebi.ac.uk/pdbsum/1K90
PDBsum	1K93	http://www.ebi.ac.uk/pdbsum/1K93
PDBsum	1L7Z	http://www.ebi.ac.uk/pdbsum/1L7Z
PDBsum	1LVC	http://www.ebi.ac.uk/pdbsum/1LVC
PDBsum	1NKF	http://www.ebi.ac.uk/pdbsum/1NKF
PDBsum	1PK0	http://www.ebi.ac.uk/pdbsum/1PK0
PDBsum	1S26	http://www.ebi.ac.uk/pdbsum/1S26
PDBsum	1SK6	http://www.ebi.ac.uk/pdbsum/1SK6
PDBsum	1SW8	http://www.ebi.ac.uk/pdbsum/1SW8
PDBsum	1WRZ	http://www.ebi.ac.uk/pdbsum/1WRZ
PDBsum	1XFU	http://www.ebi.ac.uk/pdbsum/1XFU
PDBsum	1XFV	http://www.ebi.ac.uk/pdbsum/1XFV
PDBsum	1XFW	http://www.ebi.ac.uk/pdbsum/1XFW
PDBsum	1XFX	http://www.ebi.ac.uk/pdbsum/1XFX
PDBsum	1XFY	http://www.ebi.ac.uk/pdbsum/1XFY
PDBsum	1XFZ	http://www.ebi.ac.uk/pdbsum/1XFZ
PDBsum	1Y6W	http://www.ebi.ac.uk/pdbsum/1Y6W
PDBsum	1YR5	http://www.ebi.ac.uk/pdbsum/1YR5
PDBsum	1YRT	http://www.ebi.ac.uk/pdbsum/1YRT
PDBsum	1YRU	http://www.ebi.ac.uk/pdbsum/1YRU
PDBsum	1ZOT	http://www.ebi.ac.uk/pdbsum/1ZOT
PDBsum	1ZUZ	http://www.ebi.ac.uk/pdbsum/1ZUZ
PDBsum	2BE6	http://www.ebi.ac.uk/pdbsum/2BE6
PDBsum	2F3Y	http://www.ebi.ac.uk/pdbsum/2F3Y
PDBsum	2F3Z	http://www.ebi.ac.uk/pdbsum/2F3Z
PDBsum	2HF5	http://www.ebi.ac.uk/pdbsum/2HF5
PDBsum	2I08	http://www.ebi.ac.uk/pdbsum/2I08
PDBsum	2JZI	http://www.ebi.ac.uk/pdbsum/2JZI
PDBsum	2K0E	http://www.ebi.ac.uk/pdbsum/2K0E
PDBsum	2K0F	http://www.ebi.ac.uk/pdbsum/2K0F
PDBsum	2K0J	http://www.ebi.ac.uk/pdbsum/2K0J
PDBsum	2K61	http://www.ebi.ac.uk/pdbsum/2K61
PDBsum	2KNE	http://www.ebi.ac.uk/pdbsum/2KNE
PDBsum	2KUG	http://www.ebi.ac.uk/pdbsum/2KUG
PDBsum	2KUH	http://www.ebi.ac.uk/pdbsum/2KUH
PDBsum	2L53	http://www.ebi.ac.uk/pdbsum/2L53
PDBsum	2L7L	http://www.ebi.ac.uk/pdbsum/2L7L
PDBsum	2LGF	http://www.ebi.ac.uk/pdbsum/2LGF
PDBsum	2LL6	http://www.ebi.ac.uk/pdbsum/2LL6
PDBsum	2LL7	http://www.ebi.ac.uk/pdbsum/2LL7
PDBsum	2LQC	http://www.ebi.ac.uk/pdbsum/2LQC
PDBsum	2LQP	http://www.ebi.ac.uk/pdbsum/2LQP
PDBsum	2LV6	http://www.ebi.ac.uk/pdbsum/2LV6
PDBsum	2M0J	http://www.ebi.ac.uk/pdbsum/2M0J
PDBsum	2M0K	http://www.ebi.ac.uk/pdbsum/2M0K
PDBsum	2M55	http://www.ebi.ac.uk/pdbsum/2M55
PDBsum	2MG5	http://www.ebi.ac.uk/pdbsum/2MG5
PDBsum	2N27	http://www.ebi.ac.uk/pdbsum/2N27
PDBsum	2N6A	http://www.ebi.ac.uk/pdbsum/2N6A
PDBsum	2N8J	http://www.ebi.ac.uk/pdbsum/2N8J
PDBsum	2R28	http://www.ebi.ac.uk/pdbsum/2R28
PDBsum	2V01	http://www.ebi.ac.uk/pdbsum/2V01
PDBsum	2V02	http://www.ebi.ac.uk/pdbsum/2V02
PDBsum	2VAY	http://www.ebi.ac.uk/pdbsum/2VAY
PDBsum	2W73	http://www.ebi.ac.uk/pdbsum/2W73
PDBsum	2WEL	http://www.ebi.ac.uk/pdbsum/2WEL
PDBsum	2X0G	http://www.ebi.ac.uk/pdbsum/2X0G
PDBsum	2Y4V	http://www.ebi.ac.uk/pdbsum/2Y4V
PDBsum	3BYA	http://www.ebi.ac.uk/pdbsum/3BYA
PDBsum	3DVE	http://www.ebi.ac.uk/pdbsum/3DVE
PDBsum	3DVJ	http://www.ebi.ac.uk/pdbsum/3DVJ
PDBsum	3DVK	http://www.ebi.ac.uk/pdbsum/3DVK
PDBsum	3DVM	http://www.ebi.ac.uk/pdbsum/3DVM
PDBsum	3EWT	http://www.ebi.ac.uk/pdbsum/3EWT
PDBsum	3EWV	http://www.ebi.ac.uk/pdbsum/3EWV
PDBsum	3G43	http://www.ebi.ac.uk/pdbsum/3G43
PDBsum	3HR4	http://www.ebi.ac.uk/pdbsum/3HR4
PDBsum	3J41	http://www.ebi.ac.uk/pdbsum/3J41
PDBsum	3O77	http://www.ebi.ac.uk/pdbsum/3O77
PDBsum	3O78	http://www.ebi.ac.uk/pdbsum/3O78
PDBsum	3OXQ	http://www.ebi.ac.uk/pdbsum/3OXQ
PDBsum	3SUI	http://www.ebi.ac.uk/pdbsum/3SUI
PDBsum	3UCT	http://www.ebi.ac.uk/pdbsum/3UCT
PDBsum	3UCW	http://www.ebi.ac.uk/pdbsum/3UCW
PDBsum	3UCY	http://www.ebi.ac.uk/pdbsum/3UCY
PDBsum	4BW7	http://www.ebi.ac.uk/pdbsum/4BW7
PDBsum	4BW8	http://www.ebi.ac.uk/pdbsum/4BW8
PDBsum	4BYF	http://www.ebi.ac.uk/pdbsum/4BYF
PDBsum	4DCK	http://www.ebi.ac.uk/pdbsum/4DCK
PDBsum	4DJC	http://www.ebi.ac.uk/pdbsum/4DJC
PDBsum	4GOW	http://www.ebi.ac.uk/pdbsum/4GOW
PDBsum	4JPZ	http://www.ebi.ac.uk/pdbsum/4JPZ
PDBsum	4JQ0	http://www.ebi.ac.uk/pdbsum/4JQ0
PDBsum	4L79	http://www.ebi.ac.uk/pdbsum/4L79
PDBsum	4LZX	http://www.ebi.ac.uk/pdbsum/4LZX
PDBsum	4M1L	http://www.ebi.ac.uk/pdbsum/4M1L
PDBsum	4OVN	http://www.ebi.ac.uk/pdbsum/4OVN
PDBsum	4Q57	http://www.ebi.ac.uk/pdbsum/4Q57
PDBsum	4Q5U	http://www.ebi.ac.uk/pdbsum/4Q5U
PDBsum	4UMO	http://www.ebi.ac.uk/pdbsum/4UMO
PDBsum	4UPU	http://www.ebi.ac.uk/pdbsum/4UPU
PDBsum	4V0C	http://www.ebi.ac.uk/pdbsum/4V0C
PDBsum	5COC	http://www.ebi.ac.uk/pdbsum/5COC
PDBsum	5DOW	http://www.ebi.ac.uk/pdbsum/5DOW
PDBsum	5GGM	http://www.ebi.ac.uk/pdbsum/5GGM
PDBsum	5I0I	http://www.ebi.ac.uk/pdbsum/5I0I
PDBsum	5J03	http://www.ebi.ac.uk/pdbsum/5J03
PDBsum	5J8H	http://www.ebi.ac.uk/pdbsum/5J8H
PDBsum	5K7L	http://www.ebi.ac.uk/pdbsum/5K7L
PDBsum	5K8Q	http://www.ebi.ac.uk/pdbsum/5K8Q
PROSITE	PS00018	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00018
PROSITE	PS50222	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50222
PSORT	swissprot:CALM_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CALM_HUMAN
PSORT-B	swissprot:CALM_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CALM_HUMAN
PSORT2	swissprot:CALM_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CALM_HUMAN
Pfam	PF13499	http://pfam.xfam.org/family/PF13499
PharmGKB	PA26042	http://www.pharmgkb.org/do/serve?objId=PA26042&objCls=Gene
Phobius	swissprot:CALM_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CALM_HUMAN
PhylomeDB	P62158	http://phylomedb.org/?seqid=P62158
ProteinModelPortal	P62158	http://www.proteinmodelportal.org/query/uniprot/P62158
PubMed	11685248	http://www.ncbi.nlm.nih.gov/pubmed/11685248
PubMed	11807546	http://www.ncbi.nlm.nih.gov/pubmed/11807546
PubMed	12485993	http://www.ncbi.nlm.nih.gov/pubmed/12485993
PubMed	12508121	http://www.ncbi.nlm.nih.gov/pubmed/12508121
PubMed	12577052	http://www.ncbi.nlm.nih.gov/pubmed/12577052
PubMed	12871148	http://www.ncbi.nlm.nih.gov/pubmed/12871148
PubMed	1474585	http://www.ncbi.nlm.nih.gov/pubmed/1474585
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15592455	http://www.ncbi.nlm.nih.gov/pubmed/15592455
PubMed	15719022	http://www.ncbi.nlm.nih.gov/pubmed/15719022
PubMed	15746192	http://www.ncbi.nlm.nih.gov/pubmed/15746192
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	16127172	http://www.ncbi.nlm.nih.gov/pubmed/16127172
PubMed	16299511	http://www.ncbi.nlm.nih.gov/pubmed/16299511
PubMed	16760425	http://www.ncbi.nlm.nih.gov/pubmed/16760425
PubMed	17719545	http://www.ncbi.nlm.nih.gov/pubmed/17719545
PubMed	18650434	http://www.ncbi.nlm.nih.gov/pubmed/18650434
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20466722	http://www.ncbi.nlm.nih.gov/pubmed/20466722
PubMed	21167176	http://www.ncbi.nlm.nih.gov/pubmed/21167176
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	22223895	http://www.ncbi.nlm.nih.gov/pubmed/22223895
PubMed	2223880	http://www.ncbi.nlm.nih.gov/pubmed/2223880
PubMed	22484487	http://www.ncbi.nlm.nih.gov/pubmed/22484487
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23040497	http://www.ncbi.nlm.nih.gov/pubmed/23040497
PubMed	23109337	http://www.ncbi.nlm.nih.gov/pubmed/23109337
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	23388215	http://www.ncbi.nlm.nih.gov/pubmed/23388215
PubMed	23893133	http://www.ncbi.nlm.nih.gov/pubmed/23893133
PubMed	24076290	http://www.ncbi.nlm.nih.gov/pubmed/24076290
PubMed	24129315	http://www.ncbi.nlm.nih.gov/pubmed/24129315
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	2445749	http://www.ncbi.nlm.nih.gov/pubmed/2445749
PubMed	24917665	http://www.ncbi.nlm.nih.gov/pubmed/24917665
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	3182832	http://www.ncbi.nlm.nih.gov/pubmed/3182832
PubMed	6385987	http://www.ncbi.nlm.nih.gov/pubmed/6385987
PubMed	7093203	http://www.ncbi.nlm.nih.gov/pubmed/7093203
PubMed	7803388	http://www.ncbi.nlm.nih.gov/pubmed/7803388
PubMed	7925473	http://www.ncbi.nlm.nih.gov/pubmed/7925473
PubMed	9681195	http://www.ncbi.nlm.nih.gov/pubmed/9681195
PubMed	9804419	http://www.ncbi.nlm.nih.gov/pubmed/9804419
PubMed	9927666	http://www.ncbi.nlm.nih.gov/pubmed/9927666
Reactome	R-HSA-111932	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-111932
Reactome	R-HSA-111933	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-111933
Reactome	R-HSA-111957	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-111957
Reactome	R-HSA-111997	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-111997
Reactome	R-HSA-114608	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-114608
Reactome	R-HSA-1445148	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1445148
Reactome	R-HSA-1474151	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1474151
Reactome	R-HSA-163615	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-163615
Reactome	R-HSA-180024	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-180024
Reactome	R-HSA-1855204	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1855204
Reactome	R-HSA-203615	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-203615
Reactome	R-HSA-2514859	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2514859
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
Reactome	R-HSA-2871809	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2871809
Reactome	R-HSA-4086398	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-4086398
Reactome	R-HSA-418359	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418359
Reactome	R-HSA-425561	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425561
Reactome	R-HSA-442717	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442717
Reactome	R-HSA-442729	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442729
Reactome	R-HSA-442745	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442745
Reactome	R-HSA-442982	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442982
Reactome	R-HSA-445355	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-445355
Reactome	R-HSA-451308	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-451308
Reactome	R-HSA-5210891	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5210891
Reactome	R-HSA-5218920	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5218920
Reactome	R-HSA-5218921	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5218921
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
Reactome	R-HSA-5607763	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5607763
Reactome	R-HSA-5626467	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5626467
Reactome	R-HSA-5627123	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5627123
Reactome	R-HSA-5673001	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5673001
Reactome	R-HSA-70221	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-70221
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
Reactome	R-HSA-983695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983695
RefSeq	NP_001292553	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001292553
RefSeq	NP_001292554	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001292554
RefSeq	NP_001292555	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001292555
RefSeq	NP_001316851	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001316851
RefSeq	NP_001316852	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001316852
RefSeq	NP_001316853	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001316853
RefSeq	NP_001316854	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001316854
RefSeq	NP_001316855	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001316855
RefSeq	NP_001734	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001734
RefSeq	NP_005175	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005175
RefSeq	NP_008819	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_008819
SMART	SM00054	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00054
SMR	P62158	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P62158
STRING	9606.ENSP00000349467	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000349467&targetmode=cogs
SUPFAM	SSF47473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47473
SWISS-2DPAGE	P62158	http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P62158
TCDB	8.A.82.1	http://www.tcdb.org/search/result.php?tc=8.A.82.1
UCSC	uc001xyl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001xyl&org=rat
UniGene	Hs.282410	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.282410
UniGene	Hs.468442	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.468442
UniGene	Hs.515487	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.515487
UniProtKB	CALM_HUMAN	http://www.uniprot.org/uniprot/CALM_HUMAN
UniProtKB-AC	P62158	http://www.uniprot.org/uniprot/P62158
charge	swissprot:CALM_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CALM_HUMAN
eggNOG	COG5126	http://eggnogapi.embl.de/nog_data/html/tree/COG5126
eggNOG	KOG0027	http://eggnogapi.embl.de/nog_data/html/tree/KOG0027
epestfind	swissprot:CALM_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CALM_HUMAN
garnier	swissprot:CALM_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CALM_HUMAN
helixturnhelix	swissprot:CALM_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CALM_HUMAN
hmoment	swissprot:CALM_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CALM_HUMAN
iep	swissprot:CALM_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CALM_HUMAN
inforesidue	swissprot:CALM_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CALM_HUMAN
neXtProt	NX_P62158	http://www.nextprot.org/db/entry/NX_P62158
octanol	swissprot:CALM_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CALM_HUMAN
pepcoil	swissprot:CALM_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CALM_HUMAN
pepdigest	swissprot:CALM_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CALM_HUMAN
pepinfo	swissprot:CALM_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CALM_HUMAN
pepnet	swissprot:CALM_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CALM_HUMAN
pepstats	swissprot:CALM_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CALM_HUMAN
pepwheel	swissprot:CALM_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CALM_HUMAN
pepwindow	swissprot:CALM_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CALM_HUMAN
sigcleave	swissprot:CALM_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CALM_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	NU214_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=P35658-1; Sequence=Displayed; Name=2; IsoId=P35658-2; Sequence=VSP_034896; Note=No experimental confirmation available.; Name=3; IsoId=P35658-3; Sequence=VSP_034897; Note=No experimental confirmation available.; Name=4; IsoId=P35658-4; Sequence=VSP_034896, VSP_034897; Name=5; IsoId=P35658-5; Sequence=VSP_034896, VSP_034898, VSP_034899; 
# AltName	NU214_HUMAN	214 kDa nucleoporin
# AltName	NU214_HUMAN	Nucleoporin Nup214
# AltName	NU214_HUMAN	Protein CAN
# BioGrid	113717	78
# CCDS	CCDS6940	-. [P35658-1]
# CCDS	CCDS83429	-. [P35658-4]
# ChiTaRS	NUP214	human
# DISEASE	NU214_HUMAN	Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene. {ECO 0000269|PubMed 1549122}. 
# DISEASE	NU214_HUMAN	Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET. {ECO 0000269|PubMed 1630450}. 
# DOMAIN	NU214_HUMAN	Contains FG repeats. 
# DOMAIN	NU214_HUMAN	The beta-propeller contains long interblade connector loops, and mediates interaction with DDX19B. 
# Ensembl	ENST00000359428	ENSP00000352400; ENSG00000126883. [P35658-1]
# Ensembl	ENST00000411637	ENSP00000396576; ENSG00000126883. [P35658-4]
# ExpressionAtlas	P35658	baseline and differential
# FUNCTION	NU214_HUMAN	May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. 
# GO_component	GO:0005634	nucleus; IDA:HPA.
# GO_component	GO:0005654	nucleoplasm; TAS:Reactome.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0005925	focal adhesion; IDA:HPA.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_component	GO:1990876	cytoplasmic side of nuclear pore; IDA:GO_Central.
# GO_function	GO:0005049	nuclear export signal receptor activity; IDA:GO_Central.
# GO_function	GO:0008139	nuclear localization sequence binding; IBA:GO_Central.
# GO_function	GO:0017056	structural constituent of nuclear pore; IBA:GO_Central.
# GO_process	GO:0006405	RNA export from nucleus; IBA:GO_Central.
# GO_process	GO:0006406	mRNA export from nucleus; TAS:Reactome.
# GO_process	GO:0006409	tRNA export from nucleus; TAS:Reactome.
# GO_process	GO:0006606	protein import into nucleus; IBA:GO_Central.
# GO_process	GO:0006611	protein export from nucleus; IMP:MGI.
# GO_process	GO:0007077	mitotic nuclear envelope disassembly; TAS:Reactome.
# GO_process	GO:0010827	regulation of glucose transport; TAS:Reactome.
# GO_process	GO:0016032	viral process; TAS:Reactome.
# GO_process	GO:0016925	protein sumoylation; TAS:Reactome.
# GO_process	GO:0019083	viral transcription; TAS:Reactome.
# GO_process	GO:0031047	gene silencing by RNA; TAS:Reactome.
# GO_process	GO:0043488	regulation of mRNA stability; TAS:Reactome.
# GO_process	GO:0051726	regulation of cell cycle; IEA:Ensembl.
# GO_process	GO:0075733	intracellular transport of virus; TAS:Reactome.
# GO_process	GO:1900034	regulation of cellular response to heat; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0005198	structural molecule activity
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# GOslim_process	GO:0061024	membrane organization
# Gene3D	2.130.10.10	-; 1.
# Genevisible	P35658	HS
# HGNC	HGNC:8064	NUP214
# IntAct	P35658	39
# InterPro	IPR001680	WD40_repeat
# InterPro	IPR015943	WD40/YVTN_repeat-like_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Pathway	ko03013	RNA transport
# KEGG_Pathway	ko05169	Epstein-Barr virus infection
# MIM	114350	gene
# Organism	NU214_HUMAN	Homo sapiens (Human)
# Orphanet	402014	'Acute myeloid leukemia with t(6;9)(p23;q34)'
# PDB	2OIT	X-ray; 1.65 A; A=1-434
# PDB	3FHC	X-ray; 2.80 A; A=1-405
# PDB	3FMO	X-ray; 2.51 A; A=1-450
# PDB	3FMP	X-ray; 3.19 A; A/C=1-450
# PDB	5DIS	X-ray; 2.85 A; D=1916-2027
# PIR	S26058	S26058
# PTM	NU214_HUMAN	Probably glycosylated as it reacts with wheat germ agglutinin (WGA). 
# Proteomes	UP000005640	Chromosome 9
# Reactome	R-HSA-1169408	ISG15 antiviral mechanism
# Reactome	R-HSA-159227	Transport of the SLBP independent Mature mRNA
# Reactome	R-HSA-159230	Transport of the SLBP Dependant Mature mRNA
# Reactome	R-HSA-159231	Transport of Mature mRNA Derived from an Intronless Transcript
# Reactome	R-HSA-159236	Transport of Mature mRNA derived from an Intron-Containing Transcript
# Reactome	R-HSA-165054	Rev-mediated nuclear export of HIV RNA
# Reactome	R-HSA-168271	Transport of Ribonucleoproteins into the Host Nucleus
# Reactome	R-HSA-168276	NS1 Mediated Effects on Host Pathways
# Reactome	R-HSA-168325	Viral Messenger RNA Synthesis
# Reactome	R-HSA-168333	NEP/NS2 Interacts with the Cellular Export Machinery
# Reactome	R-HSA-170822	Regulation of Glucokinase by Glucokinase Regulatory Protein
# Reactome	R-HSA-180746	Nuclear import of Rev protein
# Reactome	R-HSA-180910	Vpr-mediated nuclear import of PICs
# Reactome	R-HSA-191859	snRNP Assembly
# Reactome	R-HSA-3108214	SUMOylation of DNA damage response and repair proteins
# Reactome	R-HSA-3301854	Nuclear Pore Complex (NPC) Disassembly
# Reactome	R-HSA-3371453	Regulation of HSF1-mediated heat shock response
# Reactome	R-HSA-450520	HuR (ELAVL1) binds and stabilizes mRNA
# Reactome	R-HSA-4570464	SUMOylation of RNA binding proteins
# Reactome	R-HSA-4615885	SUMOylation of DNA replication proteins
# Reactome	R-HSA-5578749	Transcriptional regulation by small RNAs
# Reactome	R-HSA-6784531	tRNA processing in the nucleus
# RecName	NU214_HUMAN	Nuclear pore complex protein Nup214
# RefSeq	NP_001305253	NM_001318324.1. [P35658-4]
# RefSeq	NP_001305254	NM_001318325.1
# RefSeq	NP_005076	NM_005085.3. [P35658-1]
# SEQUENCE CAUTION	Sequence=BAD07398.1; Type=Erroneous initiation; Evidence={ECO	0000305}; 
# SMART	SM00320	WD40; 2
# SUBCELLULAR LOCATION	NU214_HUMAN	Nucleus, nuclear pore complex. Note=Cytoplasmic filaments. 
# SUBUNIT	(Microbial infection) Interacts with human herpes virus 1 (HHV-1) protein UL25; this interaction might be essential to the capsid docking onto the host nuclear pore. {ECO:0000269|PubMed	19386703}. 
# SUBUNIT	NU214_HUMAN	Homodimer. Interacts with NUP214; this interaction increases upon lipopolysaccharide (LPS) stimulation (PubMed 14766228). Interacts with DDX19 (PubMed 19219046, PubMed 19208808). Interacts with NUP88 (PubMed 9049309). Interacts with XPO1 (PubMed 9049309). Interacts with XPO5 (PubMed 11777942). {ECO 0000269|PubMed 11777942, ECO 0000269|PubMed 14766228, ECO 0000269|PubMed 19208808, ECO 0000269|PubMed 19219046, ECO 0000269|PubMed 9049309}. 
# TCDB	1.I.1.1	the nuclear pore complex (npc) family
# TISSUE SPECIFICITY	NU214_HUMAN	Expressed in thymus, spleen, bone marrow, kidney, brain and testis, but hardly in all other tissues or in whole embryos during development. 
# UCSC	uc004cag	human. [P35658-1]
# WEB RESOURCE	NU214_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/CANID29.html";
# eggNOG	ENOG410YBVS	LUCA
# eggNOG	KOG3630	Eukaryota
BLAST	swissprot:NU214_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NU214_HUMAN
BioCyc	ZFISH:ENSG00000126883-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000126883-MONOMER
COXPRESdb	8021	http://coxpresdb.jp/data/gene/8021.shtml
CleanEx	HS_NUP214	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_NUP214
DIP	DIP-38367N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-38367N
DOI	10.1016/j.bbrc.2004.01.080	http://dx.doi.org/10.1016/j.bbrc.2004.01.080
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr070152u	http://dx.doi.org/10.1021/pr070152u
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
DOI	10.1038/nbt1240	http://dx.doi.org/10.1038/nbt1240
DOI	10.1038/nsmb.1561	http://dx.doi.org/10.1038/nsmb.1561
DOI	10.1073/pnas.0610828104	http://dx.doi.org/10.1073/pnas.0610828104
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.0813267106	http://dx.doi.org/10.1073/pnas.0813267106
DOI	10.1073/pnas.91.4.1519	http://dx.doi.org/10.1073/pnas.91.4.1519
DOI	10.1074/mcp.M111.015131	http://dx.doi.org/10.1074/mcp.M111.015131
DOI	10.1083/jcb.200110082	http://dx.doi.org/10.1083/jcb.200110082
DOI	10.1093/dnares/1.1.27	http://dx.doi.org/10.1093/dnares/1.1.27
DOI	10.1093/emboj/16.4.807	http://dx.doi.org/10.1093/emboj/16.4.807
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1128/JVI.02655-08	http://dx.doi.org/10.1128/JVI.02655-08
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AB159230	http://www.ebi.ac.uk/ena/data/view/AB159230
EMBL	AL157938	http://www.ebi.ac.uk/ena/data/view/AL157938
EMBL	BC045620	http://www.ebi.ac.uk/ena/data/view/BC045620
EMBL	BC105998	http://www.ebi.ac.uk/ena/data/view/BC105998
EMBL	D14689	http://www.ebi.ac.uk/ena/data/view/D14689
EMBL	X64228	http://www.ebi.ac.uk/ena/data/view/X64228
Ensembl	ENST00000359428	http://www.ensembl.org/id/ENST00000359428
Ensembl	ENST00000411637	http://www.ensembl.org/id/ENST00000411637
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005925	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005925
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_component	GO:1990876	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990876
GO_function	GO:0005049	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005049
GO_function	GO:0008139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008139
GO_function	GO:0017056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017056
GO_process	GO:0006405	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006405
GO_process	GO:0006406	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006406
GO_process	GO:0006409	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006409
GO_process	GO:0006606	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006606
GO_process	GO:0006611	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006611
GO_process	GO:0007077	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007077
GO_process	GO:0010827	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010827
GO_process	GO:0016032	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016032
GO_process	GO:0016925	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016925
GO_process	GO:0019083	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019083
GO_process	GO:0031047	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031047
GO_process	GO:0043488	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043488
GO_process	GO:0051726	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051726
GO_process	GO:0075733	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0075733
GO_process	GO:1900034	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900034
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0005198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
Gene3D	2.130.10.10	http://www.cathdb.info/version/latest/superfamily/2.130.10.10
GeneCards	NUP214	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=NUP214
GeneID	8021	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8021
GeneTree	ENSGT00730000111045	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00730000111045
HGNC	HGNC:8064	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:8064
HOVERGEN	HBG052683	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052683&db=HOVERGEN
HPA	HPA018404	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA018404
HPA	HPA048789	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA048789
InParanoid	P35658	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P35658
IntAct	P35658	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P35658*
InterPro	IPR001680	http://www.ebi.ac.uk/interpro/entry/IPR001680
InterPro	IPR015943	http://www.ebi.ac.uk/interpro/entry/IPR015943
Jabion	8021	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=8021
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Gene	hsa:8021	http://www.genome.jp/dbget-bin/www_bget?hsa:8021
KEGG_Orthology	KO:K14317	http://www.genome.jp/dbget-bin/www_bget?KO:K14317
KEGG_Pathway	ko03013	http://www.genome.jp/kegg-bin/show_pathway?ko03013
KEGG_Pathway	ko05169	http://www.genome.jp/kegg-bin/show_pathway?ko05169
MIM	114350	http://www.ncbi.nlm.nih.gov/omim/114350
MINT	MINT-121482	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-121482
OMA	FNFGIIT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FNFGIIT
Orphanet	402014	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=402014
OrthoDB	EOG091G02Y1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02Y1
PDB	2OIT	http://www.ebi.ac.uk/pdbe-srv/view/entry/2OIT
PDB	3FHC	http://www.ebi.ac.uk/pdbe-srv/view/entry/3FHC
PDB	3FMO	http://www.ebi.ac.uk/pdbe-srv/view/entry/3FMO
PDB	3FMP	http://www.ebi.ac.uk/pdbe-srv/view/entry/3FMP
PDB	5DIS	http://www.ebi.ac.uk/pdbe-srv/view/entry/5DIS
PDBsum	2OIT	http://www.ebi.ac.uk/pdbsum/2OIT
PDBsum	3FHC	http://www.ebi.ac.uk/pdbsum/3FHC
PDBsum	3FMO	http://www.ebi.ac.uk/pdbsum/3FMO
PDBsum	3FMP	http://www.ebi.ac.uk/pdbsum/3FMP
PDBsum	5DIS	http://www.ebi.ac.uk/pdbsum/5DIS
PSORT	swissprot:NU214_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NU214_HUMAN
PSORT-B	swissprot:NU214_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NU214_HUMAN
PSORT2	swissprot:NU214_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NU214_HUMAN
PharmGKB	PA31851	http://www.pharmgkb.org/do/serve?objId=PA31851&objCls=Gene
Phobius	swissprot:NU214_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NU214_HUMAN
PhylomeDB	P35658	http://phylomedb.org/?seqid=P35658
ProteinModelPortal	P35658	http://www.proteinmodelportal.org/query/uniprot/P35658
PubMed	11777942	http://www.ncbi.nlm.nih.gov/pubmed/11777942
PubMed	14766228	http://www.ncbi.nlm.nih.gov/pubmed/14766228
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	1549122	http://www.ncbi.nlm.nih.gov/pubmed/1549122
PubMed	1630450	http://www.ncbi.nlm.nih.gov/pubmed/1630450
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	16964243	http://www.ncbi.nlm.nih.gov/pubmed/16964243
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	17264208	http://www.ncbi.nlm.nih.gov/pubmed/17264208
PubMed	17924679	http://www.ncbi.nlm.nih.gov/pubmed/17924679
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	19208808	http://www.ncbi.nlm.nih.gov/pubmed/19208808
PubMed	19219046	http://www.ncbi.nlm.nih.gov/pubmed/19219046
PubMed	19386703	http://www.ncbi.nlm.nih.gov/pubmed/19386703
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	22223895	http://www.ncbi.nlm.nih.gov/pubmed/22223895
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	7584026	http://www.ncbi.nlm.nih.gov/pubmed/7584026
PubMed	8108440	http://www.ncbi.nlm.nih.gov/pubmed/8108440
PubMed	9049309	http://www.ncbi.nlm.nih.gov/pubmed/9049309
Reactome	R-HSA-1169408	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1169408
Reactome	R-HSA-159227	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-159227
Reactome	R-HSA-159230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-159230
Reactome	R-HSA-159231	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-159231
Reactome	R-HSA-159236	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-159236
Reactome	R-HSA-165054	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-165054
Reactome	R-HSA-168271	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-168271
Reactome	R-HSA-168276	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-168276
Reactome	R-HSA-168325	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-168325
Reactome	R-HSA-168333	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-168333
Reactome	R-HSA-170822	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-170822
Reactome	R-HSA-180746	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-180746
Reactome	R-HSA-180910	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-180910
Reactome	R-HSA-191859	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-191859
Reactome	R-HSA-3108214	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3108214
Reactome	R-HSA-3301854	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3301854
Reactome	R-HSA-3371453	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3371453
Reactome	R-HSA-450520	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-450520
Reactome	R-HSA-4570464	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-4570464
Reactome	R-HSA-4615885	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-4615885
Reactome	R-HSA-5578749	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578749
Reactome	R-HSA-6784531	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6784531
RefSeq	NP_001305253	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001305253
RefSeq	NP_001305254	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001305254
RefSeq	NP_005076	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005076
SMART	SM00320	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00320
SMR	P35658	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P35658
STRING	9606.ENSP00000352400	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000352400&targetmode=cogs
TCDB	1.I.1.1	http://www.tcdb.org/search/result.php?tc=1.I.1.1
UCSC	uc004cag	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004cag&org=rat
UniGene	Hs.654530	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.654530
UniProtKB	NU214_HUMAN	http://www.uniprot.org/uniprot/NU214_HUMAN
UniProtKB-AC	P35658	http://www.uniprot.org/uniprot/P35658
charge	swissprot:NU214_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NU214_HUMAN
eggNOG	ENOG410YBVS	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YBVS
eggNOG	KOG3630	http://eggnogapi.embl.de/nog_data/html/tree/KOG3630
epestfind	swissprot:NU214_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NU214_HUMAN
garnier	swissprot:NU214_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NU214_HUMAN
helixturnhelix	swissprot:NU214_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NU214_HUMAN
hmoment	swissprot:NU214_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NU214_HUMAN
iep	swissprot:NU214_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NU214_HUMAN
inforesidue	swissprot:NU214_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NU214_HUMAN
neXtProt	NX_P35658	http://www.nextprot.org/db/entry/NX_P35658
octanol	swissprot:NU214_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NU214_HUMAN
pepcoil	swissprot:NU214_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NU214_HUMAN
pepdigest	swissprot:NU214_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NU214_HUMAN
pepinfo	swissprot:NU214_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NU214_HUMAN
pepnet	swissprot:NU214_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NU214_HUMAN
pepstats	swissprot:NU214_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NU214_HUMAN
pepwheel	swissprot:NU214_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NU214_HUMAN
pepwindow	swissprot:NU214_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NU214_HUMAN
sigcleave	swissprot:NU214_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NU214_HUMAN
## Database	ID	URL or Descriptions
# AltName	AT5F1_HUMAN	ATP synthase proton-transporting mitochondrial F(0) complex subunit B1
# AltName	AT5F1_HUMAN	ATP synthase subunit b
# BioGrid	107000	115
# Ensembl	ENST00000369722	ENSP00000358737; ENSG00000116459
# ExpressionAtlas	P24539	baseline and differential
# FUNCTION	AT5F1_HUMAN	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. 
# GO_component	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); IBA:GO_Central.
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005654	nucleoplasm; IDA:HPA.
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0005753	mitochondrial proton-transporting ATP synthase complex; IDA:UniProtKB.
# GO_component	GO:0005759	mitochondrial matrix; NAS:UniProtKB.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0043209	myelin sheath; IEA:Ensembl.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0015078	hydrogen ion transmembrane transporter activity; IEA:InterPro.
# GO_function	GO:0022857	transmembrane transporter activity; IC:UniProtKB.
# GO_process	GO:0006754	ATP biosynthetic process; TAS:Reactome.
# GO_process	GO:0015986	ATP synthesis coupled proton transport; IBA:GO_Central.
# GO_process	GO:0021762	substantia nigra development; IEP:UniProtKB.
# GO_process	GO:0042776	mitochondrial ATP synthesis coupled proton transport; IC:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P24539	HS
# HGNC	HGNC:840	ATP5F1
# IntAct	P24539	24
# InterPro	IPR008688	ATP_synth_Bsub_B/MI25
# InterPro	IPR013837	ATP_synth_F0_suB
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	603270	gene
# Organism	AT5F1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12733	PTHR12733
# PIR	JQ1144	JQ1144
# Pfam	PF05405	Mt_ATP-synt_B
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-163210	Formation of ATP by chemiosmotic coupling
# RecName	AT5F1_HUMAN	ATP synthase F(0) complex subunit B1, mitochondrial
# RefSeq	NP_001679	NM_001688.4
# SIMILARITY	Belongs to the eukaryotic ATPase B chain family. {ECO	0000305}.
# SUBCELLULAR LOCATION	AT5F1_HUMAN	Mitochondrion. Mitochondrion inner membrane. 
# SUBUNIT	F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits	 a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity). {ECO:0000250}. 
# eggNOG	ENOG410INNH	Eukaryota
# eggNOG	ENOG4111WYE	LUCA
BLAST	swissprot:AT5F1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AT5F1_HUMAN
BioCyc	ZFISH:HS04013-MONOMER	http://biocyc.org/getid?id=ZFISH:HS04013-MONOMER
COXPRESdb	515	http://coxpresdb.jp/data/gene/515.shtml
CleanEx	HS_ATP5F1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP5F1
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/0006-291X(91)90993-H	http://dx.doi.org/10.1016/0006-291X(91)90993-H
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AL390195	http://www.ebi.ac.uk/ena/data/view/AL390195
EMBL	BC005366	http://www.ebi.ac.uk/ena/data/view/BC005366
EMBL	BC005960	http://www.ebi.ac.uk/ena/data/view/BC005960
EMBL	BC016350	http://www.ebi.ac.uk/ena/data/view/BC016350
EMBL	X60221	http://www.ebi.ac.uk/ena/data/view/X60221
Ensembl	ENST00000369722	http://www.ensembl.org/id/ENST00000369722
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000276
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005753	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005753
GO_component	GO:0005759	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005759
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0043209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043209
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0015078	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015078
GO_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GO_process	GO:0006754	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006754
GO_process	GO:0015986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015986
GO_process	GO:0021762	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021762
GO_process	GO:0042776	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042776
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ATP5F1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP5F1
GeneID	515	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=515
GeneTree	ENSGT00390000001958	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000001958
HGNC	HGNC:840	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:840
HOGENOM	HOG000007163	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007163&db=HOGENOM6
HOVERGEN	HBG050604	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050604&db=HOVERGEN
HPA	HPA046067	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA046067
HPA	HPA057347	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA057347
InParanoid	P24539	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24539
IntAct	P24539	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24539*
InterPro	IPR008688	http://www.ebi.ac.uk/interpro/entry/IPR008688
InterPro	IPR013837	http://www.ebi.ac.uk/interpro/entry/IPR013837
Jabion	515	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=515
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:515	http://www.genome.jp/dbget-bin/www_bget?hsa:515
KEGG_Orthology	KO:K02127	http://www.genome.jp/dbget-bin/www_bget?KO:K02127
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	603270	http://www.ncbi.nlm.nih.gov/omim/603270
MINT	MINT-3010280	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3010280
OMA	VINHETF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VINHETF
OrthoDB	EOG091G0DPN	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0DPN
PANTHER	PTHR12733	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12733
PSORT	swissprot:AT5F1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AT5F1_HUMAN
PSORT-B	swissprot:AT5F1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AT5F1_HUMAN
PSORT2	swissprot:AT5F1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AT5F1_HUMAN
Pfam	PF05405	http://pfam.xfam.org/family/PF05405
PharmGKB	PA25130	http://www.pharmgkb.org/do/serve?objId=PA25130&objCls=Gene
Phobius	swissprot:AT5F1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AT5F1_HUMAN
PhylomeDB	P24539	http://phylomedb.org/?seqid=P24539
ProteinModelPortal	P24539	http://www.proteinmodelportal.org/query/uniprot/P24539
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	1831354	http://www.ncbi.nlm.nih.gov/pubmed/1831354
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-163210	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-163210
RefSeq	NP_001679	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001679
SMR	P24539	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24539
STRING	9606.ENSP00000358737	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000358737&targetmode=cogs
UniGene	Hs.514870	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.514870
UniProtKB	AT5F1_HUMAN	http://www.uniprot.org/uniprot/AT5F1_HUMAN
UniProtKB-AC	P24539	http://www.uniprot.org/uniprot/P24539
charge	swissprot:AT5F1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AT5F1_HUMAN
eggNOG	ENOG410INNH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410INNH
eggNOG	ENOG4111WYE	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111WYE
epestfind	swissprot:AT5F1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AT5F1_HUMAN
garnier	swissprot:AT5F1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AT5F1_HUMAN
helixturnhelix	swissprot:AT5F1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AT5F1_HUMAN
hmoment	swissprot:AT5F1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AT5F1_HUMAN
iep	swissprot:AT5F1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AT5F1_HUMAN
inforesidue	swissprot:AT5F1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AT5F1_HUMAN
neXtProt	NX_P24539	http://www.nextprot.org/db/entry/NX_P24539
octanol	swissprot:AT5F1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AT5F1_HUMAN
pepcoil	swissprot:AT5F1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AT5F1_HUMAN
pepdigest	swissprot:AT5F1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AT5F1_HUMAN
pepinfo	swissprot:AT5F1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AT5F1_HUMAN
pepnet	swissprot:AT5F1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AT5F1_HUMAN
pepstats	swissprot:AT5F1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AT5F1_HUMAN
pepwheel	swissprot:AT5F1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AT5F1_HUMAN
pepwindow	swissprot:AT5F1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AT5F1_HUMAN
sigcleave	swissprot:AT5F1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AT5F1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ATP7A_HUMAN	Event=Alternative splicing; Named isoforms=6; Name=4; IsoId=Q04656-1; Sequence=Displayed; Name=1; IsoId=Q04656-2; Sequence=VSP_000419; Name=2; IsoId=Q04656-3; Sequence=VSP_000420; Name=3; Synonyms=2-16; IsoId=Q04656-4; Sequence=VSP_000424; Note=Lacks 6 transmembrane regions and 5 heavy-metal-associated (HMA) domains.; Name=5; IsoId=Q04656-5; Sequence=VSP_000425; Note=Lacks the transmembrane domains 3 and 4. Expressed at a low level in several tissues of normal individuals and is the only isoform found in patients with OHS.; Name=6; Synonyms=NML45; IsoId=Q04656-6; Sequence=VSP_000421, VSP_000422, VSP_000423; Note=Lacks all transmembrane regions and 5 heavy-metal-associated (HMA) domains, but has a putative nuclear localization signal attached at the N-terminus.; 
# AltName	ATP7A_HUMAN	Copper pump 1
# AltName	ATP7A_HUMAN	Menkes disease-associated protein
# BRENDA	3.6.3	2681
# BioGrid	107020	22
# CATALYTIC ACTIVITY	ATP7A_HUMAN	ATP + H(2)O + Cu(+)(Side 1) = ADP + phosphate + Cu(+)(Side 2). 
# CCDS	CCDS35339	-. [Q04656-1]
# CCDS	CCDS75997	-. [Q04656-5]
# CDD	cd00371	HMA; 6
# ChiTaRS	ATP7A	human
# DISEASE	ATP7A_HUMAN	Distal spinal muscular atrophy, X-linked, 3 (DSMAX3) [MIM 300489]  A neuromuscular disorder. Distal spinal muscular atrophy, also known as distal hereditary motor neuronopathy, represents a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs. {ECO 0000269|PubMed 20170900}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ATP7A_HUMAN	Menkes disease (MNKD) [MIM 309400]  An X-linked recessive disorder of copper metabolism characterized by generalized copper deficiency. MNKD results in progressive neurodegeneration and connective-tissue disturbances  focal cerebral and cerebellar degeneration, early growth retardation, peculiar hair, hypopigmentation, cutis laxa, vascular complications and death in early childhood. The clinical features result from the dysfunction of several copper-dependent enzymes. A mild form of the disease has been described, in which cerebellar ataxia and moderate developmental delay predominate. {ECO 0000269|PubMed 10079817, ECO 0000269|PubMed 10319589, ECO 0000269|PubMed 10401004, ECO 0000269|PubMed 11241493, ECO 0000269|PubMed 11350187, ECO 0000269|PubMed 15981243, ECO 0000269|PubMed 21667063, ECO 0000269|PubMed 22992316, ECO 0000269|PubMed 7977350, ECO 0000269|PubMed 8981948}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ATP7A_HUMAN	Occipital horn syndrome (OHS) [MIM 304150]  An X-linked recessive disorder of copper metabolism. Common features are unusual facial appearance, skeletal abnormalities, chronic diarrhea and genitourinary defects. The skeletal abnormalities include occipital horns, short, broad clavicles, deformed radii, ulnae and humeri, narrowing of the rib cage, undercalcified long bones with thin cortical walls and coxa valga. {ECO 0000269|PubMed 11431706, ECO 0000269|PubMed 17108763, ECO 0000269|PubMed 21667063, ECO 0000269|PubMed 9246006}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	ATP7A_HUMAN	The C-terminal di-leucine, 1487-Leu-Leu-1488, is an endocytic targeting signal which functions in retrieving recycling from the plasma membrane to the TGN. Mutation of the di-leucine signal results in the accumulation of the protein in the plasma membrane. 
# DrugBank	DB00515	Cisplatin
# DrugBank	DB00526	Oxaliplatin
# DrugBank	DB00958	Carboplatin
# Ensembl	ENST00000341514	ENSP00000345728; ENSG00000165240
# Ensembl	ENST00000343533	ENSP00000343026; ENSG00000165240
# Ensembl	ENST00000350425	ENSP00000343678; ENSG00000165240
# FUNCTION	ATP7A_HUMAN	May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells. 
# GO_component	GO:0005770	late endosome; IDA:UniProtKB.
# GO_component	GO:0005783	endoplasmic reticulum; IDA:UniProtKB.
# GO_component	GO:0005794	Golgi apparatus; IDA:UniProtKB.
# GO_component	GO:0005802	trans-Golgi network; IDA:UniProtKB.
# GO_component	GO:0005829	cytosol; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016323	basolateral plasma membrane; IDA:UniProtKB.
# GO_component	GO:0030140	trans-Golgi network transport vesicle; IMP:HGNC.
# GO_component	GO:0030141	secretory granule; IEA:Ensembl.
# GO_component	GO:0031526	brush border membrane; IEA:Ensembl.
# GO_component	GO:0043005	neuron projection; ISS:UniProtKB.
# GO_component	GO:0043025	neuronal cell body; ISS:UniProtKB.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IDA:UniProtKB.
# GO_function	GO:0004008	copper-exporting ATPase activity; ISS:UniProtKB.
# GO_function	GO:0005375	copper ion transmembrane transporter activity; ISS:UniProtKB.
# GO_function	GO:0005507	copper ion binding; IDA:UniProtKB.
# GO_function	GO:0005524	ATP binding; TAS:HGNC.
# GO_function	GO:0016532	superoxide dismutase copper chaperone activity; ISS:UniProtKB.
# GO_function	GO:0032767	copper-dependent protein binding; IPI:UniProtKB.
# GO_process	GO:0001568	blood vessel development; ISS:UniProtKB.
# GO_process	GO:0001701	in utero embryonic development; IEA:Ensembl.
# GO_process	GO:0001974	blood vessel remodeling; ISS:UniProtKB.
# GO_process	GO:0002082	regulation of oxidative phosphorylation; ISS:UniProtKB.
# GO_process	GO:0006568	tryptophan metabolic process; ISS:UniProtKB.
# GO_process	GO:0006584	catecholamine metabolic process; ISS:UniProtKB.
# GO_process	GO:0006825	copper ion transport; IMP:UniProtKB.
# GO_process	GO:0006878	cellular copper ion homeostasis; IMP:UniProtKB.
# GO_process	GO:0007005	mitochondrion organization; ISS:UniProtKB.
# GO_process	GO:0007595	lactation; IEA:Ensembl.
# GO_process	GO:0007626	locomotory behavior; ISS:UniProtKB.
# GO_process	GO:0010041	response to iron(III) ion; IEA:Ensembl.
# GO_process	GO:0010043	response to zinc ion; IEA:Ensembl.
# GO_process	GO:0010273	detoxification of copper ion; ISS:UniProtKB.
# GO_process	GO:0015677	copper ion import; ISS:UniProtKB.
# GO_process	GO:0015679	plasma membrane copper ion transport; IEA:Ensembl.
# GO_process	GO:0018205	peptidyl-lysine modification; ISS:UniProtKB.
# GO_process	GO:0019430	removal of superoxide radicals; ISS:UniProtKB.
# GO_process	GO:0021702	cerebellar Purkinje cell differentiation; ISS:UniProtKB.
# GO_process	GO:0021860	pyramidal neuron development; ISS:UniProtKB.
# GO_process	GO:0021954	central nervous system neuron development; ISS:UniProtKB.
# GO_process	GO:0030198	extracellular matrix organization; ISS:UniProtKB.
# GO_process	GO:0030199	collagen fibril organization; ISS:UniProtKB.
# GO_process	GO:0031069	hair follicle morphogenesis; ISS:UniProtKB.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0042093	T-helper cell differentiation; ISS:UniProtKB.
# GO_process	GO:0042414	epinephrine metabolic process; ISS:UniProtKB.
# GO_process	GO:0042415	norepinephrine metabolic process; ISS:UniProtKB.
# GO_process	GO:0042417	dopamine metabolic process; ISS:UniProtKB.
# GO_process	GO:0042428	serotonin metabolic process; ISS:UniProtKB.
# GO_process	GO:0043085	positive regulation of catalytic activity; ISS:UniProtKB.
# GO_process	GO:0043086	negative regulation of catalytic activity; ISS:UniProtKB.
# GO_process	GO:0043473	pigmentation; ISS:UniProtKB.
# GO_process	GO:0043588	skin development; ISS:UniProtKB.
# GO_process	GO:0048251	elastic fiber assembly; ISS:UniProtKB.
# GO_process	GO:0048286	lung alveolus development; ISS:UniProtKB.
# GO_process	GO:0048812	neuron projection morphogenesis; ISS:UniProtKB.
# GO_process	GO:0051216	cartilage development; ISS:UniProtKB.
# GO_process	GO:0051353	positive regulation of oxidoreductase activity; IDA:UniProtKB.
# GO_process	GO:0051542	elastin biosynthetic process; ISS:UniProtKB.
# GO_process	GO:0060003	copper ion export; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0030234	enzyme regulator activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0006520	cellular amino acid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007005	mitochondrion organization
# GOslim_process	GO:0007155	cell adhesion
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0009790	embryo development
# GOslim_process	GO:0022607	cellular component assembly
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0030198	extracellular matrix organization
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0043473	pigmentation
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.70.150.10	-; 1.
# Gene3D	3.40.1110.10	-; 2.
# Gene3D	3.40.50.1000	-; 2.
# Genevisible	Q04656	HS
# HGNC	HGNC:869	ATP7A
# INTERACTION	ATP7A_HUMAN	Q5EBL8 PDZD11; NbExp=4; IntAct=EBI-7706409, EBI-1644207; 
# IntAct	Q04656	4
# InterPro	IPR001757	P_typ_ATPase
# InterPro	IPR006121	HMA_dom
# InterPro	IPR006122	HMA_Cu_ion-bd
# InterPro	IPR008250	ATPase_P-typ_transduc_dom_A
# InterPro	IPR017969	Heavy-metal-associated_CS
# InterPro	IPR018303	ATPase_P-typ_P_site
# InterPro	IPR023214	HAD-like_dom
# InterPro	IPR023299	ATPase_P-typ_cyto_domN
# InterPro	IPR027256	P-typ_ATPase_IB
# KEGG_Brite	ko01000	Enzymes
# KEGG_Disease	H00209	[Inherited metabolic disease; Nervous system disease; Skin and connective tissue disease] Menkes kinky hair syndrome
# KEGG_Disease	H00455	[Neurodegenerative disease] SMA proximal adult autosomal dominant (SMAPAD)
# KEGG_Disease	H00557	[Developmental disorder; Skin and connective tissue disease] Wrinkly skin syndrome
# KEGG_Disease	H00856	[Nervous system disease] Distal hereditary motor neuropathies (dHMN)
# MIM	300011	gene
# MIM	300489	phenotype
# MIM	304150	phenotype
# MIM	309400	phenotype
# Organism	ATP7A_HUMAN	Homo sapiens (Human)
# Orphanet	139557	X-linked distal spinal muscular atrophy
# Orphanet	198	Occipital horn syndrome
# Orphanet	565	Menkes disease
# PDB	1AW0	NMR; -; A=375-446
# PDB	1KVI	NMR; -; A=1-79
# PDB	1KVJ	NMR; -; A=1-79
# PDB	1Q8L	NMR; -; A=164-246
# PDB	1S6O	NMR; -; A=169-240
# PDB	1S6U	NMR; -; A=169-240
# PDB	1Y3J	NMR; -; A=486-558
# PDB	1Y3K	NMR; -; A=486-558
# PDB	1YJR	NMR; -; A=562-633
# PDB	1YJT	NMR; -; A=562-633
# PDB	1YJU	NMR; -; A=562-633
# PDB	1YJV	NMR; -; A=562-633
# PDB	2AW0	NMR; -; A=375-446
# PDB	2G9O	NMR; -; A=275-352
# PDB	2GA7	NMR; -; A=275-352
# PDB	2K1R	NMR; -; A=5-77
# PDB	2KIJ	NMR; -; A=806-924
# PDB	2KMV	NMR; -; A=1051-1231
# PDB	2KMX	NMR; -; A=1051-1231
# PDB	3CJK	X-ray; 1.80 A; B=7-77
# PDB	5T7L	X-ray; 2.83 A; B=7-77
# PIR	S36149	S36149
# PROSITE	PS00154	ATPASE_E1_E2
# PROSITE	PS01047	HMA_1; 6
# PROSITE	PS50846	HMA_2; 6
# Pfam	PF00122	E1-E2_ATPase
# Pfam	PF00403	HMA; 6
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-3299685	Detoxification of Reactive Oxygen Species
# Reactome	R-HSA-6803544	Ion influx/efflux at host-pathogen interface
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	ATP7A_HUMAN	Copper-transporting ATPase 1
# RefSeq	NP_000043	NM_000052.6
# RefSeq	NP_001269153	NM_001282224.1
# SIMILARITY	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 6 HMA domains. {ECO:0000255|PROSITE- ProRule	PRU00280}. 
# SUBCELLULAR LOCATION	ATP7A_HUMAN	Golgi apparatus, trans-Golgi network membrane {ECO 0000269|PubMed 10484781, ECO 0000269|PubMed 9147644, ECO 0000269|PubMed 9467005}; Multi-pass membrane protein {ECO 0000255}. Cell membrane {ECO 0000269|PubMed 10484781, ECO 0000269|PubMed 9147644}; Multi-pass membrane protein {ECO 0000255}. Note=Cycles constitutively between the trans-Golgi network (TGN) and the plasma membrane (PubMed 9147644). Predominantly found in the TGN and relocalized to the plasma membrane in response to elevated copper levels. {ECO 0000269|PubMed 9147644}. 
# SUBCELLULAR LOCATION	ATP7A_HUMAN	Isoform 3  Cytoplasm, cytosol {ECO 0000305}. 
# SUBCELLULAR LOCATION	ATP7A_HUMAN	Isoform 5  Endoplasmic reticulum {ECO 0000269|PubMed 9467005}. 
# SUBUNIT	ATP7A_HUMAN	Monomer. Interacts with PDZD11. Interacts with ATOX1 and COMMD1 (PubMed 21667063). {ECO 0000269|PubMed 16051599, ECO 0000269|PubMed 21667063}. 
# SUPFAM	SSF55008	SSF55008; 6
# SUPFAM	SSF56784	SSF56784; 2
# SUPFAM	SSF81660	SSF81660; 2
# TCDB	3.A.3.5	the p-type atpase (p-atpase) superfamily
# TIGRFAMs	TIGR00003	TIGR00003; 6
# TIGRFAMs	TIGR01494	ATPase_P-type; 2
# TIGRFAMs	TIGR01525	ATPase-IB_hvy
# TISSUE SPECIFICITY	ATP7A_HUMAN	Found in most tissues except liver. Isoform 3 is widely expressed including in liver cell lines. Isoform 1 is expressed in fibroblasts, choriocarcinoma, colon carcinoma and neuroblastoma cell lines. Isoform 2 is expressed in fibroblasts, colon carcinoma and neuroblastoma cell lines. 
# UCSC	uc004ecx	human. [Q04656-1]
# WEB RESOURCE	ATP7A_HUMAN	Name=Protein Spotlight; Note=Heavy metal - Issue 79 of February 2007; URL="http //web.expasy.org/spotlight/back_issues/079";
# eggNOG	COG2217	LUCA
# eggNOG	KOG0207	Eukaryota
BLAST	swissprot:ATP7A_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ATP7A_HUMAN
BioCyc	ZFISH:HS09205-MONOMER	http://biocyc.org/getid?id=ZFISH:HS09205-MONOMER
COG	COG2217	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2217
COXPRESdb	538	http://coxpresdb.jp/data/gene/538.shtml
CleanEx	HS_ATP7A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP7A
DOI	10.1002/1096-8628(2001)9999:9999<::AID-AJMG1167>3.0.CO	http://dx.doi.org/10.1002/1096-8628(2001)9999:9999<::AID-AJMG1167>3.0.CO
DOI	10.1002/humu.20190	http://dx.doi.org/10.1002/humu.20190
DOI	10.1006/geno.1995.1175	http://dx.doi.org/10.1006/geno.1995.1175
DOI	10.1006/mgme.2001.3169	http://dx.doi.org/10.1006/mgme.2001.3169
DOI	10.1007/s00018-011-0743-1	http://dx.doi.org/10.1007/s00018-011-0743-1
DOI	10.1007/s100380050144	http://dx.doi.org/10.1007/s100380050144
DOI	10.1016/0888-7543(95)80160-N	http://dx.doi.org/10.1016/0888-7543(95)80160-N
DOI	10.1016/j.ajhg.2010.01.027	http://dx.doi.org/10.1016/j.ajhg.2010.01.027
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/35054550	http://dx.doi.org/10.1038/35054550
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1038/ng0193-14	http://dx.doi.org/10.1038/ng0193-14
DOI	10.1038/ng0193-20	http://dx.doi.org/10.1038/ng0193-20
DOI	10.1038/ng0193-7	http://dx.doi.org/10.1038/ng0193-7
DOI	10.1038/nsb0198-47	http://dx.doi.org/10.1038/nsb0198-47
DOI	10.1042/bj3340071	http://dx.doi.org/10.1042/bj3340071
DOI	10.1042/bj3500855	http://dx.doi.org/10.1042/bj3500855
DOI	10.1074/jbc.M505889200	http://dx.doi.org/10.1074/jbc.M505889200
DOI	10.1086/321290	http://dx.doi.org/10.1086/321290
DOI	10.1086/516852	http://dx.doi.org/10.1086/516852
DOI	10.1093/hmg/6.3.409	http://dx.doi.org/10.1093/hmg/6.3.409
DOI	10.1093/hmg/7.3.465	http://dx.doi.org/10.1093/hmg/7.3.465
DOI	10.1093/hmg/8.11.2107	http://dx.doi.org/10.1093/hmg/8.11.2107
DOI	10.1093/hmg/8.8.1547	http://dx.doi.org/10.1093/hmg/8.8.1547
DOI	10.1097/01.gim.0000245578.94312.1e	http://dx.doi.org/10.1097/01.gim.0000245578.94312.1e
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1186/1471-2431-12-150	http://dx.doi.org/10.1186/1471-2431-12-150
DisProt	DP00282	http://www.disprot.org/protein.php?id=DP00282
DrugBank	DB00515	http://www.drugbank.ca/drugs/DB00515
DrugBank	DB00526	http://www.drugbank.ca/drugs/DB00526
DrugBank	DB00958	http://www.drugbank.ca/drugs/DB00958
EC_number	EC:3.6.3.54	http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.54
EMBL	AL645821	http://www.ebi.ac.uk/ena/data/view/AL645821
EMBL	AY011418	http://www.ebi.ac.uk/ena/data/view/AY011418
EMBL	CH471104	http://www.ebi.ac.uk/ena/data/view/CH471104
EMBL	L06133	http://www.ebi.ac.uk/ena/data/view/L06133
EMBL	L06476	http://www.ebi.ac.uk/ena/data/view/L06476
EMBL	U27361	http://www.ebi.ac.uk/ena/data/view/U27361
EMBL	U27362	http://www.ebi.ac.uk/ena/data/view/U27362
EMBL	U27363	http://www.ebi.ac.uk/ena/data/view/U27363
EMBL	U27365	http://www.ebi.ac.uk/ena/data/view/U27365
EMBL	U27366	http://www.ebi.ac.uk/ena/data/view/U27366
EMBL	U27367	http://www.ebi.ac.uk/ena/data/view/U27367
EMBL	U27368	http://www.ebi.ac.uk/ena/data/view/U27368
EMBL	U27369	http://www.ebi.ac.uk/ena/data/view/U27369
EMBL	U27370	http://www.ebi.ac.uk/ena/data/view/U27370
EMBL	U27371	http://www.ebi.ac.uk/ena/data/view/U27371
EMBL	U27372	http://www.ebi.ac.uk/ena/data/view/U27372
EMBL	U27373	http://www.ebi.ac.uk/ena/data/view/U27373
EMBL	U27374	http://www.ebi.ac.uk/ena/data/view/U27374
EMBL	U27375	http://www.ebi.ac.uk/ena/data/view/U27375
EMBL	U27376	http://www.ebi.ac.uk/ena/data/view/U27376
EMBL	U27377	http://www.ebi.ac.uk/ena/data/view/U27377
EMBL	U27378	http://www.ebi.ac.uk/ena/data/view/U27378
EMBL	U27379	http://www.ebi.ac.uk/ena/data/view/U27379
EMBL	U27380	http://www.ebi.ac.uk/ena/data/view/U27380
EMBL	U27381	http://www.ebi.ac.uk/ena/data/view/U27381
EMBL	X69208	http://www.ebi.ac.uk/ena/data/view/X69208
EMBL	X82336	http://www.ebi.ac.uk/ena/data/view/X82336
EMBL	X82337	http://www.ebi.ac.uk/ena/data/view/X82337
EMBL	X82338	http://www.ebi.ac.uk/ena/data/view/X82338
EMBL	X82339	http://www.ebi.ac.uk/ena/data/view/X82339
EMBL	X82340	http://www.ebi.ac.uk/ena/data/view/X82340
EMBL	X82341	http://www.ebi.ac.uk/ena/data/view/X82341
EMBL	X82342	http://www.ebi.ac.uk/ena/data/view/X82342
EMBL	X82343	http://www.ebi.ac.uk/ena/data/view/X82343
EMBL	X82344	http://www.ebi.ac.uk/ena/data/view/X82344
EMBL	X82345	http://www.ebi.ac.uk/ena/data/view/X82345
EMBL	X82346	http://www.ebi.ac.uk/ena/data/view/X82346
EMBL	X82347	http://www.ebi.ac.uk/ena/data/view/X82347
EMBL	X82348	http://www.ebi.ac.uk/ena/data/view/X82348
EMBL	X82349	http://www.ebi.ac.uk/ena/data/view/X82349
EMBL	X82350	http://www.ebi.ac.uk/ena/data/view/X82350
EMBL	X82351	http://www.ebi.ac.uk/ena/data/view/X82351
EMBL	X82352	http://www.ebi.ac.uk/ena/data/view/X82352
EMBL	X82353	http://www.ebi.ac.uk/ena/data/view/X82353
EMBL	X82354	http://www.ebi.ac.uk/ena/data/view/X82354
EMBL	X82355	http://www.ebi.ac.uk/ena/data/view/X82355
EMBL	X82356	http://www.ebi.ac.uk/ena/data/view/X82356
EMBL	Z94753	http://www.ebi.ac.uk/ena/data/view/Z94753
EMBL	Z94801	http://www.ebi.ac.uk/ena/data/view/Z94801
ENZYME	3.6.3.54	http://enzyme.expasy.org/EC/3.6.3.54
Ensembl	ENST00000341514	http://www.ensembl.org/id/ENST00000341514
Ensembl	ENST00000343533	http://www.ensembl.org/id/ENST00000343533
Ensembl	ENST00000350425	http://www.ensembl.org/id/ENST00000350425
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005770	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005770
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005802	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005802
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0030140	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030140
GO_component	GO:0030141	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030141
GO_component	GO:0031526	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031526
GO_component	GO:0043005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043005
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_function	GO:0004008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004008
GO_function	GO:0005375	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005375
GO_function	GO:0005507	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005507
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0016532	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016532
GO_function	GO:0032767	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032767
GO_process	GO:0001568	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001568
GO_process	GO:0001701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001701
GO_process	GO:0001974	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001974
GO_process	GO:0002082	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002082
GO_process	GO:0006568	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006568
GO_process	GO:0006584	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006584
GO_process	GO:0006825	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006825
GO_process	GO:0006878	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006878
GO_process	GO:0007005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007005
GO_process	GO:0007595	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007595
GO_process	GO:0007626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007626
GO_process	GO:0010041	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010041
GO_process	GO:0010043	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010043
GO_process	GO:0010273	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010273
GO_process	GO:0015677	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015677
GO_process	GO:0015679	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015679
GO_process	GO:0018205	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018205
GO_process	GO:0019430	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019430
GO_process	GO:0021702	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021702
GO_process	GO:0021860	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021860
GO_process	GO:0021954	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021954
GO_process	GO:0030198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030198
GO_process	GO:0030199	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030199
GO_process	GO:0031069	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031069
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0042093	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042093
GO_process	GO:0042414	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042414
GO_process	GO:0042415	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042415
GO_process	GO:0042417	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042417
GO_process	GO:0042428	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042428
GO_process	GO:0043085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043085
GO_process	GO:0043086	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043086
GO_process	GO:0043473	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043473
GO_process	GO:0043588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043588
GO_process	GO:0048251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048251
GO_process	GO:0048286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048286
GO_process	GO:0048812	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048812
GO_process	GO:0051216	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051216
GO_process	GO:0051353	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051353
GO_process	GO:0051542	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051542
GO_process	GO:0060003	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060003
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0030234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0006520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007005
GOslim_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0009790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009790
GOslim_process	GO:0022607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0030198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030198
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0043473	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043473
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.70.150.10	http://www.cathdb.info/version/latest/superfamily/2.70.150.10
Gene3D	3.40.1110.10	http://www.cathdb.info/version/latest/superfamily/3.40.1110.10
Gene3D	3.40.50.1000	http://www.cathdb.info/version/latest/superfamily/3.40.50.1000
GeneCards	ATP7A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP7A
GeneID	538	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=538
HGNC	HGNC:869	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:869
HOGENOM	HOG000250397	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000250397&db=HOGENOM6
HOVERGEN	HBG050616	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050616&db=HOVERGEN
HPA	HPA012887	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA012887
HPA	HPA048107	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA048107
InParanoid	Q04656	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q04656
IntAct	Q04656	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q04656*
IntEnz	3.6.3.54	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.54
InterPro	IPR001757	http://www.ebi.ac.uk/interpro/entry/IPR001757
InterPro	IPR006121	http://www.ebi.ac.uk/interpro/entry/IPR006121
InterPro	IPR006122	http://www.ebi.ac.uk/interpro/entry/IPR006122
InterPro	IPR008250	http://www.ebi.ac.uk/interpro/entry/IPR008250
InterPro	IPR017969	http://www.ebi.ac.uk/interpro/entry/IPR017969
InterPro	IPR018303	http://www.ebi.ac.uk/interpro/entry/IPR018303
InterPro	IPR023214	http://www.ebi.ac.uk/interpro/entry/IPR023214
InterPro	IPR023299	http://www.ebi.ac.uk/interpro/entry/IPR023299
InterPro	IPR027256	http://www.ebi.ac.uk/interpro/entry/IPR027256
Jabion	538	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=538
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Disease	H00209	http://www.genome.jp/dbget-bin/www_bget?H00209
KEGG_Disease	H00455	http://www.genome.jp/dbget-bin/www_bget?H00455
KEGG_Disease	H00557	http://www.genome.jp/dbget-bin/www_bget?H00557
KEGG_Disease	H00856	http://www.genome.jp/dbget-bin/www_bget?H00856
KEGG_Gene	hsa:538	http://www.genome.jp/dbget-bin/www_bget?hsa:538
KEGG_Orthology	KO:K01533	http://www.genome.jp/dbget-bin/www_bget?KO:K01533
MIM	300011	http://www.ncbi.nlm.nih.gov/omim/300011
MIM	300489	http://www.ncbi.nlm.nih.gov/omim/300489
MIM	304150	http://www.ncbi.nlm.nih.gov/omim/304150
MIM	309400	http://www.ncbi.nlm.nih.gov/omim/309400
MINT	MINT-106053	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-106053
Orphanet	139557	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=139557
Orphanet	198	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=198
Orphanet	565	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=565
OrthoDB	EOG091G022E	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G022E
PDB	1AW0	http://www.ebi.ac.uk/pdbe-srv/view/entry/1AW0
PDB	1KVI	http://www.ebi.ac.uk/pdbe-srv/view/entry/1KVI
PDB	1KVJ	http://www.ebi.ac.uk/pdbe-srv/view/entry/1KVJ
PDB	1Q8L	http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q8L
PDB	1S6O	http://www.ebi.ac.uk/pdbe-srv/view/entry/1S6O
PDB	1S6U	http://www.ebi.ac.uk/pdbe-srv/view/entry/1S6U
PDB	1Y3J	http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y3J
PDB	1Y3K	http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y3K
PDB	1YJR	http://www.ebi.ac.uk/pdbe-srv/view/entry/1YJR
PDB	1YJT	http://www.ebi.ac.uk/pdbe-srv/view/entry/1YJT
PDB	1YJU	http://www.ebi.ac.uk/pdbe-srv/view/entry/1YJU
PDB	1YJV	http://www.ebi.ac.uk/pdbe-srv/view/entry/1YJV
PDB	2AW0	http://www.ebi.ac.uk/pdbe-srv/view/entry/2AW0
PDB	2G9O	http://www.ebi.ac.uk/pdbe-srv/view/entry/2G9O
PDB	2GA7	http://www.ebi.ac.uk/pdbe-srv/view/entry/2GA7
PDB	2K1R	http://www.ebi.ac.uk/pdbe-srv/view/entry/2K1R
PDB	2KIJ	http://www.ebi.ac.uk/pdbe-srv/view/entry/2KIJ
PDB	2KMV	http://www.ebi.ac.uk/pdbe-srv/view/entry/2KMV
PDB	2KMX	http://www.ebi.ac.uk/pdbe-srv/view/entry/2KMX
PDB	3CJK	http://www.ebi.ac.uk/pdbe-srv/view/entry/3CJK
PDB	5T7L	http://www.ebi.ac.uk/pdbe-srv/view/entry/5T7L
PDBsum	1AW0	http://www.ebi.ac.uk/pdbsum/1AW0
PDBsum	1KVI	http://www.ebi.ac.uk/pdbsum/1KVI
PDBsum	1KVJ	http://www.ebi.ac.uk/pdbsum/1KVJ
PDBsum	1Q8L	http://www.ebi.ac.uk/pdbsum/1Q8L
PDBsum	1S6O	http://www.ebi.ac.uk/pdbsum/1S6O
PDBsum	1S6U	http://www.ebi.ac.uk/pdbsum/1S6U
PDBsum	1Y3J	http://www.ebi.ac.uk/pdbsum/1Y3J
PDBsum	1Y3K	http://www.ebi.ac.uk/pdbsum/1Y3K
PDBsum	1YJR	http://www.ebi.ac.uk/pdbsum/1YJR
PDBsum	1YJT	http://www.ebi.ac.uk/pdbsum/1YJT
PDBsum	1YJU	http://www.ebi.ac.uk/pdbsum/1YJU
PDBsum	1YJV	http://www.ebi.ac.uk/pdbsum/1YJV
PDBsum	2AW0	http://www.ebi.ac.uk/pdbsum/2AW0
PDBsum	2G9O	http://www.ebi.ac.uk/pdbsum/2G9O
PDBsum	2GA7	http://www.ebi.ac.uk/pdbsum/2GA7
PDBsum	2K1R	http://www.ebi.ac.uk/pdbsum/2K1R
PDBsum	2KIJ	http://www.ebi.ac.uk/pdbsum/2KIJ
PDBsum	2KMV	http://www.ebi.ac.uk/pdbsum/2KMV
PDBsum	2KMX	http://www.ebi.ac.uk/pdbsum/2KMX
PDBsum	3CJK	http://www.ebi.ac.uk/pdbsum/3CJK
PDBsum	5T7L	http://www.ebi.ac.uk/pdbsum/5T7L
PROSITE	PS00154	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00154
PROSITE	PS01047	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01047
PROSITE	PS50846	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50846
PSORT	swissprot:ATP7A_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ATP7A_HUMAN
PSORT-B	swissprot:ATP7A_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ATP7A_HUMAN
PSORT2	swissprot:ATP7A_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ATP7A_HUMAN
Pfam	PF00122	http://pfam.xfam.org/family/PF00122
Pfam	PF00403	http://pfam.xfam.org/family/PF00403
PharmGKB	PA72	http://www.pharmgkb.org/do/serve?objId=PA72&objCls=Gene
Phobius	swissprot:ATP7A_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ATP7A_HUMAN
PhylomeDB	Q04656	http://phylomedb.org/?seqid=Q04656
ProteinModelPortal	Q04656	http://www.proteinmodelportal.org/query/uniprot/Q04656
PubMed	10079814	http://www.ncbi.nlm.nih.gov/pubmed/10079814
PubMed	10079817	http://www.ncbi.nlm.nih.gov/pubmed/10079817
PubMed	10319589	http://www.ncbi.nlm.nih.gov/pubmed/10319589
PubMed	10401004	http://www.ncbi.nlm.nih.gov/pubmed/10401004
PubMed	10484781	http://www.ncbi.nlm.nih.gov/pubmed/10484781
PubMed	10970802	http://www.ncbi.nlm.nih.gov/pubmed/10970802
PubMed	11214319	http://www.ncbi.nlm.nih.gov/pubmed/11214319
PubMed	11241493	http://www.ncbi.nlm.nih.gov/pubmed/11241493
PubMed	11350187	http://www.ncbi.nlm.nih.gov/pubmed/11350187
PubMed	11431706	http://www.ncbi.nlm.nih.gov/pubmed/11431706
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	15981243	http://www.ncbi.nlm.nih.gov/pubmed/15981243
PubMed	16051599	http://www.ncbi.nlm.nih.gov/pubmed/16051599
PubMed	17108763	http://www.ncbi.nlm.nih.gov/pubmed/17108763
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	20170900	http://www.ncbi.nlm.nih.gov/pubmed/20170900
PubMed	21667063	http://www.ncbi.nlm.nih.gov/pubmed/21667063
PubMed	22992316	http://www.ncbi.nlm.nih.gov/pubmed/22992316
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	7490081	http://www.ncbi.nlm.nih.gov/pubmed/7490081
PubMed	7607665	http://www.ncbi.nlm.nih.gov/pubmed/7607665
PubMed	7977350	http://www.ncbi.nlm.nih.gov/pubmed/7977350
PubMed	8490646	http://www.ncbi.nlm.nih.gov/pubmed/8490646
PubMed	8490647	http://www.ncbi.nlm.nih.gov/pubmed/8490647
PubMed	8490659	http://www.ncbi.nlm.nih.gov/pubmed/8490659
PubMed	8981948	http://www.ncbi.nlm.nih.gov/pubmed/8981948
PubMed	9147644	http://www.ncbi.nlm.nih.gov/pubmed/9147644
PubMed	9246006	http://www.ncbi.nlm.nih.gov/pubmed/9246006
PubMed	9437429	http://www.ncbi.nlm.nih.gov/pubmed/9437429
PubMed	9467005	http://www.ncbi.nlm.nih.gov/pubmed/9467005
PubMed	9693104	http://www.ncbi.nlm.nih.gov/pubmed/9693104
Reactome	R-HSA-3299685	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3299685
Reactome	R-HSA-6803544	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6803544
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_000043	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000043
RefSeq	NP_001269153	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269153
SMR	Q04656	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q04656
STRING	9606.ENSP00000345728	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000345728&targetmode=cogs
STRING	COG2217	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2217&targetmode=cogs
SUPFAM	SSF55008	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55008
SUPFAM	SSF56784	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784
SUPFAM	SSF81660	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81660
TCDB	3.A.3.5	http://www.tcdb.org/search/result.php?tc=3.A.3.5
TIGRFAMs	TIGR00003	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00003
TIGRFAMs	TIGR01494	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01494
TIGRFAMs	TIGR01525	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01525
UCSC	uc004ecx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004ecx&org=rat
UniGene	Hs.496414	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.496414
UniGene	Hs.733232	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.733232
UniProtKB	ATP7A_HUMAN	http://www.uniprot.org/uniprot/ATP7A_HUMAN
UniProtKB-AC	Q04656	http://www.uniprot.org/uniprot/Q04656
charge	swissprot:ATP7A_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ATP7A_HUMAN
eggNOG	COG2217	http://eggnogapi.embl.de/nog_data/html/tree/COG2217
eggNOG	KOG0207	http://eggnogapi.embl.de/nog_data/html/tree/KOG0207
epestfind	swissprot:ATP7A_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ATP7A_HUMAN
garnier	swissprot:ATP7A_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ATP7A_HUMAN
helixturnhelix	swissprot:ATP7A_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATP7A_HUMAN
hmoment	swissprot:ATP7A_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ATP7A_HUMAN
iep	swissprot:ATP7A_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ATP7A_HUMAN
inforesidue	swissprot:ATP7A_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ATP7A_HUMAN
neXtProt	NX_Q04656	http://www.nextprot.org/db/entry/NX_Q04656
octanol	swissprot:ATP7A_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ATP7A_HUMAN
pepcoil	swissprot:ATP7A_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ATP7A_HUMAN
pepdigest	swissprot:ATP7A_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ATP7A_HUMAN
pepinfo	swissprot:ATP7A_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ATP7A_HUMAN
pepnet	swissprot:ATP7A_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ATP7A_HUMAN
pepstats	swissprot:ATP7A_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ATP7A_HUMAN
pepwheel	swissprot:ATP7A_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ATP7A_HUMAN
pepwindow	swissprot:ATP7A_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ATP7A_HUMAN
sigcleave	swissprot:ATP7A_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ATP7A_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AT133_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H7F0-1; Sequence=Displayed; Name=2; IsoId=Q9H7F0-2; Sequence=VSP_007314, VSP_036300, VSP_007315, VSP_007316; Note=Dubious isoform produced through aberrant splice sites.; 
# AltName	AT133_HUMAN	ATPase family homolog up-regulated in senescence cells 1
# BioGrid	122719	11
# CATALYTIC ACTIVITY	AT133_HUMAN	ATP + H(2)O = ADP + phosphate. 
# CCDS	CCDS43187	-. [Q9H7F0-1]
# ChiTaRS	ATP13A3	human
# Ensembl	ENST00000256031	ENSP00000256031; ENSG00000133657. [Q9H7F0-1]
# Ensembl	ENST00000439040	ENSP00000416508; ENSG00000133657. [Q9H7F0-1]
# ExpressionAtlas	Q9H7F0	baseline and differential
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IBA:GO_Central.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0019829	cation-transporting ATPase activity; IBA:GO_Central.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0006874	cellular calcium ion homeostasis; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0042592	homeostatic process
# Gene3D	2.70.150.10	-; 1.
# Gene3D	3.40.1110.10	-; 2.
# Gene3D	3.40.50.1000	-; 2.
# Genevisible	Q9H7F0	HS
# HGNC	HGNC:24113	ATP13A3
# IntAct	Q9H7F0	4
# InterPro	IPR001757	P_typ_ATPase
# InterPro	IPR004014	ATPase_P-typ_cation-transptr_N
# InterPro	IPR006068	ATPase_P-typ_cation-transptr_C
# InterPro	IPR006544	P-type_TPase_V
# InterPro	IPR008250	ATPase_P-typ_transduc_dom_A
# InterPro	IPR018303	ATPase_P-typ_P_site
# InterPro	IPR023214	HAD-like_dom
# InterPro	IPR023299	ATPase_P-typ_cyto_domN
# KEGG_Brite	ko01000	Enzymes
# MIM	610232	gene
# Organism	AT133_HUMAN	Homo sapiens (Human)
# PROSITE	PS00154	ATPASE_E1_E2
# Pfam	PF00122	E1-E2_ATPase
# Pfam	PF00689	Cation_ATPase_C
# Pfam	PF00690	Cation_ATPase_N
# Pfam	PF12409	P5-ATPase
# Proteomes	UP000005640	Chromosome 3
# RecName	AT133_HUMAN	Probable cation-transporting ATPase 13A3
# RefSeq	NP_078800	NM_024524.3. [Q9H7F0-1]
# RefSeq	XP_011511425	XM_011513123.2. [Q9H7F0-1]
# SEQUENCE CAUTION	Sequence=BAB14942.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14942.1; Type=Frameshift; Positions=1065; Evidence={ECO	0000305}; Sequence=BAC11398.1; Type=Erroneous initiation; Evidence={ECO:0000305};
# SIMILARITY	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	AT133_HUMAN	Membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUPFAM	SSF56784	SSF56784; 3
# SUPFAM	SSF81660	SSF81660; 2
# TIGRFAMs	TIGR01494	ATPase_P-type; 3
# TIGRFAMs	TIGR01657	P-ATPase-V
# UCSC	uc003fty	human. [Q9H7F0-1]
# eggNOG	ENOG410XRCA	LUCA
# eggNOG	KOG0208	Eukaryota
BLAST	swissprot:AT133_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AT133_HUMAN
BioCyc	ZFISH:ENSG00000133657-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000133657-MONOMER
COXPRESdb	79572	http://coxpresdb.jp/data/gene/79572.shtml
CleanEx	HS_ATP13A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP13A3
DOI	10.1016/S0378-1119(01)00881-2	http://dx.doi.org/10.1016/S0378-1119(01)00881-2
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
EC_number	EC:3.6.3.-	http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.-
EMBL	AC108676	http://www.ebi.ac.uk/ena/data/view/AC108676
EMBL	AC125362	http://www.ebi.ac.uk/ena/data/view/AC125362
EMBL	AJ306929	http://www.ebi.ac.uk/ena/data/view/AJ306929
EMBL	AK024639	http://www.ebi.ac.uk/ena/data/view/AK024639
EMBL	AK075094	http://www.ebi.ac.uk/ena/data/view/AK075094
ENZYME	3.6.3.-	http://enzyme.expasy.org/EC/3.6.3.-
Ensembl	ENST00000256031	http://www.ensembl.org/id/ENST00000256031
Ensembl	ENST00000439040	http://www.ensembl.org/id/ENST00000439040
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0019829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019829
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
Gene3D	2.70.150.10	http://www.cathdb.info/version/latest/superfamily/2.70.150.10
Gene3D	3.40.1110.10	http://www.cathdb.info/version/latest/superfamily/3.40.1110.10
Gene3D	3.40.50.1000	http://www.cathdb.info/version/latest/superfamily/3.40.50.1000
GeneCards	ATP13A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP13A3
GeneID	79572	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79572
GeneTree	ENSGT00530000063001	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063001
HGNC	HGNC:24113	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:24113
HOGENOM	HOG000171813	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000171813&db=HOGENOM6
HOVERGEN	HBG065757	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG065757&db=HOVERGEN
HPA	HPA029471	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA029471
InParanoid	Q9H7F0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9H7F0
IntAct	Q9H7F0	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9H7F0*
IntEnz	3.6.3	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3
InterPro	IPR001757	http://www.ebi.ac.uk/interpro/entry/IPR001757
InterPro	IPR004014	http://www.ebi.ac.uk/interpro/entry/IPR004014
InterPro	IPR006068	http://www.ebi.ac.uk/interpro/entry/IPR006068
InterPro	IPR006544	http://www.ebi.ac.uk/interpro/entry/IPR006544
InterPro	IPR008250	http://www.ebi.ac.uk/interpro/entry/IPR008250
InterPro	IPR018303	http://www.ebi.ac.uk/interpro/entry/IPR018303
InterPro	IPR023214	http://www.ebi.ac.uk/interpro/entry/IPR023214
InterPro	IPR023299	http://www.ebi.ac.uk/interpro/entry/IPR023299
Jabion	79572	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=79572
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:79572	http://www.genome.jp/dbget-bin/www_bget?hsa:79572
KEGG_Orthology	KO:K14951	http://www.genome.jp/dbget-bin/www_bget?KO:K14951
MIM	610232	http://www.ncbi.nlm.nih.gov/omim/610232
OMA	ENRHRIS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ENRHRIS
OrthoDB	EOG091G01IL	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01IL
PROSITE	PS00154	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00154
PSORT	swissprot:AT133_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AT133_HUMAN
PSORT-B	swissprot:AT133_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AT133_HUMAN
PSORT2	swissprot:AT133_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AT133_HUMAN
Pfam	PF00122	http://pfam.xfam.org/family/PF00122
Pfam	PF00689	http://pfam.xfam.org/family/PF00689
Pfam	PF00690	http://pfam.xfam.org/family/PF00690
Pfam	PF12409	http://pfam.xfam.org/family/PF12409
PharmGKB	PA134971145	http://www.pharmgkb.org/do/serve?objId=PA134971145&objCls=Gene
Phobius	swissprot:AT133_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AT133_HUMAN
PhylomeDB	Q9H7F0	http://phylomedb.org/?seqid=Q9H7F0
ProteinModelPortal	Q9H7F0	http://www.proteinmodelportal.org/query/uniprot/Q9H7F0
PubMed	11867234	http://www.ncbi.nlm.nih.gov/pubmed/11867234
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
RefSeq	NP_078800	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_078800
RefSeq	XP_011511425	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011511425
STRING	9606.ENSP00000256031	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000256031&targetmode=cogs
SUPFAM	SSF56784	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784
SUPFAM	SSF81660	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81660
TIGRFAMs	TIGR01494	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01494
TIGRFAMs	TIGR01657	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01657
UCSC	uc003fty	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003fty&org=rat
UniGene	Hs.529609	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.529609
UniProtKB	AT133_HUMAN	http://www.uniprot.org/uniprot/AT133_HUMAN
UniProtKB-AC	Q9H7F0	http://www.uniprot.org/uniprot/Q9H7F0
charge	swissprot:AT133_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AT133_HUMAN
eggNOG	ENOG410XRCA	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRCA
eggNOG	KOG0208	http://eggnogapi.embl.de/nog_data/html/tree/KOG0208
epestfind	swissprot:AT133_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AT133_HUMAN
garnier	swissprot:AT133_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AT133_HUMAN
helixturnhelix	swissprot:AT133_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AT133_HUMAN
hmoment	swissprot:AT133_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AT133_HUMAN
iep	swissprot:AT133_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AT133_HUMAN
inforesidue	swissprot:AT133_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AT133_HUMAN
neXtProt	NX_Q9H7F0	http://www.nextprot.org/db/entry/NX_Q9H7F0
octanol	swissprot:AT133_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AT133_HUMAN
pepcoil	swissprot:AT133_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AT133_HUMAN
pepdigest	swissprot:AT133_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AT133_HUMAN
pepinfo	swissprot:AT133_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AT133_HUMAN
pepnet	swissprot:AT133_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AT133_HUMAN
pepstats	swissprot:AT133_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AT133_HUMAN
pepwheel	swissprot:AT133_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AT133_HUMAN
pepwindow	swissprot:AT133_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AT133_HUMAN
sigcleave	swissprot:AT133_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AT133_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AT2A3_HUMAN	Event=Alternative splicing; Named isoforms=7; Comment=The same names have been attributed to different isoforms.; Name=SERCA3B; IsoId=Q93084-1; Sequence=Displayed; Name=SERCA3A; Synonyms=HuS3-II; IsoId=Q93084-2; Sequence=VSP_000364; Name=SERCA3C; Synonyms=HuS3-IV; IsoId=Q93084-3; Sequence=VSP_000366; Name=SERCA3G; Synonyms=HuS3-I; IsoId=Q93084-4; Sequence=VSP_000365; Name=SERCA3E; IsoId=Q93084-5; Sequence=VSP_000367; Name=SERCA3D; IsoId=Q93084-6; Sequence=VSP_000368; Name=SERCA3F; IsoId=Q93084-7; Sequence=VSP_042296; 
# AltName	AT2A3_HUMAN	Calcium pump 3
# BioGrid	106979	49
# CATALYTIC ACTIVITY	AT2A3_HUMAN	ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2). 
# CCDS	CCDS11041	-. [Q93084-1]
# CCDS	CCDS11042	-. [Q93084-5]
# CCDS	CCDS42234	-. [Q93084-3]
# CCDS	CCDS45579	-. [Q93084-2]
# CCDS	CCDS45580	-. [Q93084-4]
# ChiTaRS	ATP2A3	human
# ENZYME REGULATION	AT2A3_HUMAN	Inhibited by sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN) (By similarity). Enhanced by DWORF; DWORF increases activity by displacing sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN) (By similarity). {ECO 0000250|UniProtKB P04191, ECO 0000250|UniProtKB Q8R429}. 
# Ensembl	ENST00000309890	ENSP00000312577; ENSG00000074370. [Q93084-3]
# Ensembl	ENST00000352011	ENSP00000301387; ENSG00000074370. [Q93084-1]
# Ensembl	ENST00000359983	ENSP00000353072; ENSG00000074370. [Q93084-5]
# Ensembl	ENST00000397035	ENSP00000380229; ENSG00000074370. [Q93084-3]
# Ensembl	ENST00000397041	ENSP00000380234; ENSG00000074370. [Q93084-2]
# Ensembl	ENST00000397043	ENSP00000380236; ENSG00000074370. [Q93084-4]
# ExpressionAtlas	Q93084	baseline and differential
# FUNCTION	AT2A3_HUMAN	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. {ECO 0000269|PubMed 11956212, ECO 0000269|PubMed 15028735}. 
# GO_component	GO:0005783	endoplasmic reticulum; IDA:UniProtKB.
# GO_component	GO:0005789	endoplasmic reticulum membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016529	sarcoplasmic reticulum; IDA:UniProtKB.
# GO_component	GO:0031095	platelet dense tubular network membrane; TAS:Reactome.
# GO_component	GO:0031965	nuclear membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0033017	sarcoplasmic reticulum membrane; IBA:GO_Central.
# GO_function	GO:0005388	calcium-transporting ATPase activity; TAS:Reactome.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006816	calcium ion transport; TAS:UniProtKB.
# GO_process	GO:0006874	cellular calcium ion homeostasis; IBA:GO_Central.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.1110.10	-; 2.
# Gene3D	2.70.150.10	-; 2.
# Gene3D	3.40.1110.10	-; 1.
# Genevisible	Q93084	HS
# HGNC	HGNC:813	ATP2A3
# IntAct	Q93084	6
# InterPro	IPR001757	P_typ_ATPase
# InterPro	IPR004014	ATPase_P-typ_cation-transptr_N
# InterPro	IPR005782	P-type_ATPase_IIA
# InterPro	IPR006068	ATPase_P-typ_cation-transptr_C
# InterPro	IPR008250	ATPase_P-typ_transduc_dom_A
# InterPro	IPR018303	ATPase_P-typ_P_site
# InterPro	IPR023214	HAD-like_dom
# InterPro	IPR023298	ATPase_P-typ_TM_dom
# InterPro	IPR023299	ATPase_P-typ_cyto_domN
# InterPro	IPR030330	SERCA3
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04972	Pancreatic secretion
# KEGG_Pathway	ko05010	Alzheimer's disease
# MIM	601929	gene
# Organism	AT2A3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR24093:SF295	PTHR24093:SF295; 2
# PIR	I55399	I55399
# PIR	S72267	S72267
# PRINTS	PR00120	HATPASE
# PROSITE	PS00154	ATPASE_E1_E2
# Pfam	PF00122	E1-E2_ATPase
# Pfam	PF00689	Cation_ATPase_C
# Pfam	PF00690	Cation_ATPase_N
# Pfam	PF08282	Hydrolase_3
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-1912420	Pre-NOTCH Processing in Golgi
# Reactome	R-HSA-418359	Reduction of cytosolic Ca++ levels
# Reactome	R-HSA-5578775	Ion homeostasis
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	AT2A3_HUMAN	Sarcoplasmic/endoplasmic reticulum calcium ATPase 3
# RefSeq	NP_005164	NM_005173.3. [Q93084-2]
# RefSeq	NP_777613	NM_174953.2. [Q93084-5]
# RefSeq	NP_777614	NM_174954.2. [Q93084-6]
# RefSeq	NP_777615	NM_174955.2. [Q93084-1]
# RefSeq	NP_777616	NM_174956.2. [Q93084-3]
# RefSeq	NP_777617	NM_174957.2. [Q93084-4]
# RefSeq	NP_777618	NM_174958.2. [Q93084-3]
# SIMILARITY	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. {ECO	0000305}.
# SMART	SM00831	Cation_ATPase_N
# SUBCELLULAR LOCATION	AT2A3_HUMAN	Nucleus membrane {ECO 0000269|PubMed 15028735}; Multi-pass membrane protein {ECO 0000269|PubMed 15028735}. Endoplasmic reticulum membrane {ECO 0000269|PubMed 15028735}; Multi-pass membrane protein {ECO 0000269|PubMed 15028735}. Sarcoplasmic reticulum membrane {ECO 0000269|PubMed 15028735}; Multi-pass membrane protein {ECO 0000269|PubMed 15028735}. 
# SUBUNIT	AT2A3_HUMAN	Interacts with sarcolipin (SLN) (By similarity). Interacts with phospholamban (PLN) (By similarity). Interacts with myoregulin (MRLN). Interacts with DWORF (By similarity). {ECO 0000250|UniProtKB P04191, ECO 0000250|UniProtKB Q8R429}. 
# SUPFAM	SSF56784	SSF56784
# SUPFAM	SSF81660	SSF81660
# TIGRFAMs	TIGR01116	ATPase-IIA1_Ca
# TIGRFAMs	TIGR01494	ATPase_P-type; 2
# TISSUE SPECIFICITY	AT2A3_HUMAN	Found in most tissues. Most abundant in thymus, trachea, salivary gland, spleen, bone marrow, lymph node, peripheral leukocytes, pancreas and colon. Also detected in fetal tissues. Expressed in cell lineages of hematopoietic, epithelial, or embryonic origin and also expressed in several cancer cell lines. {ECO 0000269|PubMed 11956212, ECO 0000269|PubMed 15028735}. 
# UCSC	uc002fwx	human. [Q93084-1]
# eggNOG	COG0474	LUCA
# eggNOG	KOG0202	Eukaryota
BLAST	swissprot:AT2A3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AT2A3_HUMAN
BioCyc	ZFISH:HS01138-MONOMER	http://biocyc.org/getid?id=ZFISH:HS01138-MONOMER
COXPRESdb	489	http://coxpresdb.jp/data/gene/489.shtml
CleanEx	HS_ATP2A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP2A3
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1038/nbt810	http://dx.doi.org/10.1038/nbt810
DOI	10.1042/bj3180689	http://dx.doi.org/10.1042/bj3180689
DOI	10.1074/jbc.273.22.13982	http://dx.doi.org/10.1074/jbc.273.22.13982
DOI	10.1074/jbc.M202011200	http://dx.doi.org/10.1074/jbc.M202011200
DOI	10.1074/jbc.M314286200	http://dx.doi.org/10.1074/jbc.M314286200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EC_number	EC:3.6.3.8	http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.8
EMBL	AC005940	http://www.ebi.ac.uk/ena/data/view/AC005940
EMBL	AF068220	http://www.ebi.ac.uk/ena/data/view/AF068220
EMBL	AF068221	http://www.ebi.ac.uk/ena/data/view/AF068221
EMBL	AF458228	http://www.ebi.ac.uk/ena/data/view/AF458228
EMBL	AF458229	http://www.ebi.ac.uk/ena/data/view/AF458229
EMBL	AY460339	http://www.ebi.ac.uk/ena/data/view/AY460339
EMBL	BC035729	http://www.ebi.ac.uk/ena/data/view/BC035729
EMBL	CH471108	http://www.ebi.ac.uk/ena/data/view/CH471108
EMBL	CH471108	http://www.ebi.ac.uk/ena/data/view/CH471108
EMBL	CH471108	http://www.ebi.ac.uk/ena/data/view/CH471108
EMBL	S68239	http://www.ebi.ac.uk/ena/data/view/S68239
EMBL	Y15724	http://www.ebi.ac.uk/ena/data/view/Y15724
EMBL	Y15725	http://www.ebi.ac.uk/ena/data/view/Y15725
EMBL	Y15726	http://www.ebi.ac.uk/ena/data/view/Y15726
EMBL	Y15727	http://www.ebi.ac.uk/ena/data/view/Y15727
EMBL	Y15728	http://www.ebi.ac.uk/ena/data/view/Y15728
EMBL	Y15729	http://www.ebi.ac.uk/ena/data/view/Y15729
EMBL	Y15730	http://www.ebi.ac.uk/ena/data/view/Y15730
EMBL	Y15737	http://www.ebi.ac.uk/ena/data/view/Y15737
EMBL	Y15738	http://www.ebi.ac.uk/ena/data/view/Y15738
EMBL	Z69880	http://www.ebi.ac.uk/ena/data/view/Z69880
EMBL	Z69881	http://www.ebi.ac.uk/ena/data/view/Z69881
ENZYME	3.6.3.8	http://enzyme.expasy.org/EC/3.6.3.8
Ensembl	ENST00000309890	http://www.ensembl.org/id/ENST00000309890
Ensembl	ENST00000352011	http://www.ensembl.org/id/ENST00000352011
Ensembl	ENST00000359983	http://www.ensembl.org/id/ENST00000359983
Ensembl	ENST00000397035	http://www.ensembl.org/id/ENST00000397035
Ensembl	ENST00000397041	http://www.ensembl.org/id/ENST00000397041
Ensembl	ENST00000397043	http://www.ensembl.org/id/ENST00000397043
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016529	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016529
GO_component	GO:0031095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031095
GO_component	GO:0031965	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031965
GO_component	GO:0033017	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033017
GO_function	GO:0005388	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005388
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0006874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.1110.10	http://www.cathdb.info/version/latest/superfamily/1.20.1110.10
Gene3D	2.70.150.10	http://www.cathdb.info/version/latest/superfamily/2.70.150.10
Gene3D	3.40.1110.10	http://www.cathdb.info/version/latest/superfamily/3.40.1110.10
GeneCards	ATP2A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP2A3
GeneID	489	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=489
GeneTree	ENSGT00850000132256	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00850000132256
HGNC	HGNC:813	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:813
HOGENOM	HOG000078632	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000078632&db=HOGENOM6
HOVERGEN	HBG105648	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG105648&db=HOVERGEN
HPA	CAB010882	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB010882
HPA	HPA007180	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA007180
InParanoid	Q93084	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q93084
IntAct	Q93084	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q93084*
IntEnz	3.6.3.8	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.8
InterPro	IPR001757	http://www.ebi.ac.uk/interpro/entry/IPR001757
InterPro	IPR004014	http://www.ebi.ac.uk/interpro/entry/IPR004014
InterPro	IPR005782	http://www.ebi.ac.uk/interpro/entry/IPR005782
InterPro	IPR006068	http://www.ebi.ac.uk/interpro/entry/IPR006068
InterPro	IPR008250	http://www.ebi.ac.uk/interpro/entry/IPR008250
InterPro	IPR018303	http://www.ebi.ac.uk/interpro/entry/IPR018303
InterPro	IPR023214	http://www.ebi.ac.uk/interpro/entry/IPR023214
InterPro	IPR023298	http://www.ebi.ac.uk/interpro/entry/IPR023298
InterPro	IPR023299	http://www.ebi.ac.uk/interpro/entry/IPR023299
InterPro	IPR030330	http://www.ebi.ac.uk/interpro/entry/IPR030330
Jabion	489	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=489
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:489	http://www.genome.jp/dbget-bin/www_bget?hsa:489
KEGG_Orthology	KO:K05853	http://www.genome.jp/dbget-bin/www_bget?KO:K05853
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
MIM	601929	http://www.ncbi.nlm.nih.gov/omim/601929
OMA	WSRQPLT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WSRQPLT
OrthoDB	EOG091G01LE	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01LE
PANTHER	PTHR24093:SF295	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24093:SF295
PRINTS	PR00120	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00120
PROSITE	PS00154	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00154
PSORT	swissprot:AT2A3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AT2A3_HUMAN
PSORT-B	swissprot:AT2A3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AT2A3_HUMAN
PSORT2	swissprot:AT2A3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AT2A3_HUMAN
Pfam	PF00122	http://pfam.xfam.org/family/PF00122
Pfam	PF00689	http://pfam.xfam.org/family/PF00689
Pfam	PF00690	http://pfam.xfam.org/family/PF00690
Pfam	PF08282	http://pfam.xfam.org/family/PF08282
PharmGKB	PA25106	http://www.pharmgkb.org/do/serve?objId=PA25106&objCls=Gene
Phobius	swissprot:AT2A3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AT2A3_HUMAN
PhylomeDB	Q93084	http://phylomedb.org/?seqid=Q93084
ProteinModelPortal	Q93084	http://www.proteinmodelportal.org/query/uniprot/Q93084
PubMed	11956212	http://www.ncbi.nlm.nih.gov/pubmed/11956212
PubMed	12665801	http://www.ncbi.nlm.nih.gov/pubmed/12665801
PubMed	15028735	http://www.ncbi.nlm.nih.gov/pubmed/15028735
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	8288608	http://www.ncbi.nlm.nih.gov/pubmed/8288608
PubMed	8809064	http://www.ncbi.nlm.nih.gov/pubmed/8809064
PubMed	9593748	http://www.ncbi.nlm.nih.gov/pubmed/9593748
PubMed	9843705	http://www.ncbi.nlm.nih.gov/pubmed/9843705
Reactome	R-HSA-1912420	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1912420
Reactome	R-HSA-418359	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418359
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_005164	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005164
RefSeq	NP_777613	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_777613
RefSeq	NP_777614	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_777614
RefSeq	NP_777615	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_777615
RefSeq	NP_777616	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_777616
RefSeq	NP_777617	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_777617
RefSeq	NP_777618	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_777618
SMART	SM00831	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00831
SMR	Q93084	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q93084
STRING	9606.ENSP00000353072	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000353072&targetmode=cogs
SUPFAM	SSF56784	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784
SUPFAM	SSF81660	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81660
TIGRFAMs	TIGR01116	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01116
TIGRFAMs	TIGR01494	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01494
UCSC	uc002fwx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002fwx&org=rat
UniGene	Hs.513870	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.513870
UniProtKB	AT2A3_HUMAN	http://www.uniprot.org/uniprot/AT2A3_HUMAN
UniProtKB-AC	Q93084	http://www.uniprot.org/uniprot/Q93084
charge	swissprot:AT2A3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AT2A3_HUMAN
eggNOG	COG0474	http://eggnogapi.embl.de/nog_data/html/tree/COG0474
eggNOG	KOG0202	http://eggnogapi.embl.de/nog_data/html/tree/KOG0202
epestfind	swissprot:AT2A3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AT2A3_HUMAN
garnier	swissprot:AT2A3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AT2A3_HUMAN
helixturnhelix	swissprot:AT2A3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AT2A3_HUMAN
hmoment	swissprot:AT2A3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AT2A3_HUMAN
iep	swissprot:AT2A3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AT2A3_HUMAN
inforesidue	swissprot:AT2A3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AT2A3_HUMAN
neXtProt	NX_Q93084	http://www.nextprot.org/db/entry/NX_Q93084
octanol	swissprot:AT2A3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AT2A3_HUMAN
pepcoil	swissprot:AT2A3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AT2A3_HUMAN
pepdigest	swissprot:AT2A3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AT2A3_HUMAN
pepinfo	swissprot:AT2A3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AT2A3_HUMAN
pepnet	swissprot:AT2A3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AT2A3_HUMAN
pepstats	swissprot:AT2A3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AT2A3_HUMAN
pepwheel	swissprot:AT2A3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AT2A3_HUMAN
pepwindow	swissprot:AT2A3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AT2A3_HUMAN
sigcleave	swissprot:AT2A3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AT2A3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CHMP7_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8WUX9-1; Sequence=Displayed; Name=2; IsoId=Q8WUX9-2; Sequence=VSP_056945, VSP_056946; Note=No experimental confirmation available.; 
# AltName	CHMP7_HUMAN	Chromatin-modifying protein 7
# BioGrid	124879	11
# CCDS	CCDS6040	-. [Q8WUX9-1]
# ChiTaRS	CHMP7	human
# Ensembl	ENST00000313219	ENSP00000324491; ENSG00000147457. [Q8WUX9-1]
# Ensembl	ENST00000397677	ENSP00000380794; ENSG00000147457. [Q8WUX9-1]
# Ensembl	ENST00000519503	ENSP00000427948; ENSG00000147457. [Q8WUX9-2]
# ExpressionAtlas	Q8WUX9	baseline and differential
# FUNCTION	CHMP7_HUMAN	ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase (PubMed 26040712). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed 26040712). Plays a role in the endosomal sorting pathway (PubMed 16856878). {ECO 0000269|PubMed 16856878, ECO 0000269|PubMed 26040712}. 
# GO_component	GO:0000815	ESCRT III complex; IDA:UniProtKB.
# GO_component	GO:0005635	nuclear envelope; IDA:UniProtKB.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_function	GO:0008565	protein transporter activity; IMP:UniProtKB.
# GO_process	GO:0000920	cell separation after cytokinesis; IMP:UniProtKB.
# GO_process	GO:0006997	nucleus organization; IMP:UniProtKB.
# GO_process	GO:0007080	mitotic metaphase plate congression; IMP:UniProtKB.
# GO_process	GO:0010458	exit from mitosis; IMP:UniProtKB.
# GO_process	GO:0016197	endosomal transport; TAS:Reactome.
# GO_process	GO:0019058	viral life cycle; TAS:Reactome.
# GO_process	GO:0031468	nuclear envelope reassembly; IMP:UniProtKB.
# GO_process	GO:0036258	multivesicular body assembly; NAS:ParkinsonsUK-UCL.
# GO_process	GO:0039702	viral budding via host ESCRT complex; NAS:ParkinsonsUK-UCL.
# GO_process	GO:0045324	late endosome to vacuole transport; IMP:UniProtKB.
# GO_process	GO:1904903	ESCRT III complex disassembly; NAS:ParkinsonsUK-UCL.
# GOslim_component	GO:0005635	nuclear envelope
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007034	vacuolar transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0022607	cellular component assembly
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# GOslim_process	GO:0061024	membrane organization
# Genevisible	Q8WUX9	HS
# HGNC	HGNC:28439	CHMP7
# INTERACTION	CHMP7_HUMAN	Q9H444 CHMP4B; NbExp=3; IntAct=EBI-749253, EBI-749627; 
# IntAct	Q8WUX9	6
# InterPro	IPR005024	Snf7_fam
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Pathway	ko04144	Endocytosis
# MIM	611130	gene
# Organism	CHMP7_HUMAN	Homo sapiens (Human)
# Pfam	PF03357	Snf7
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-162588	Budding and maturation of HIV virion
# Reactome	R-HSA-1632852	Macroautophagy
# Reactome	R-HSA-917729	Endosomal Sorting Complex Required For Transport (ESCRT)
# RecName	CHMP7_HUMAN	Charged multivesicular body protein 7
# RefSeq	NP_689485	NM_152272.4. [Q8WUX9-1]
# SIMILARITY	Belongs to the SNF7 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	CHMP7_HUMAN	Cytoplasm {ECO 0000269|PubMed 16856878}. Nucleus envelope {ECO 0000269|PubMed 26040712}. Note=Diffused localization, with some punctate distribution, especially in the perinuclear area (PubMed 16856878). Localizes to the nucleus envelope during late anaphase (PubMed 26040712). {ECO 0000269|PubMed 16856878, ECO 0000269|PubMed 26040712}. 
# SUBUNIT	Interacts with CHMP4B, but not with VPS25. {ECO:0000269|PubMed	16856878}. 
# UCSC	uc003xdc	human. [Q8WUX9-1]
# eggNOG	ENOG4110IXB	LUCA
# eggNOG	KOG2911	Eukaryota
BLAST	swissprot:CHMP7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CHMP7_HUMAN
BioCyc	ZFISH:ENSG00000147457-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000147457-MONOMER
COXPRESdb	91782	http://coxpresdb.jp/data/gene/91782.shtml
CleanEx	HS_CHMP7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CHMP7
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04406	http://dx.doi.org/10.1038/nature04406
DOI	10.1038/nature14408	http://dx.doi.org/10.1038/nature14408
DOI	10.1038/nbt1240	http://dx.doi.org/10.1038/nbt1240
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/BJ20060897	http://dx.doi.org/10.1042/BJ20060897
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AC100861	http://www.ebi.ac.uk/ena/data/view/AC100861
EMBL	AK296592	http://www.ebi.ac.uk/ena/data/view/AK296592
EMBL	AK315664	http://www.ebi.ac.uk/ena/data/view/AK315664
EMBL	AL833843	http://www.ebi.ac.uk/ena/data/view/AL833843
EMBL	BC004344	http://www.ebi.ac.uk/ena/data/view/BC004344
EMBL	BC019110	http://www.ebi.ac.uk/ena/data/view/BC019110
EMBL	BC042050	http://www.ebi.ac.uk/ena/data/view/BC042050
EMBL	CH471080	http://www.ebi.ac.uk/ena/data/view/CH471080
EMBL	CH471080	http://www.ebi.ac.uk/ena/data/view/CH471080
Ensembl	ENST00000313219	http://www.ensembl.org/id/ENST00000313219
Ensembl	ENST00000397677	http://www.ensembl.org/id/ENST00000397677
Ensembl	ENST00000519503	http://www.ensembl.org/id/ENST00000519503
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000815	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000815
GO_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0000920	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000920
GO_process	GO:0006997	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006997
GO_process	GO:0007080	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007080
GO_process	GO:0010458	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010458
GO_process	GO:0016197	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016197
GO_process	GO:0019058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019058
GO_process	GO:0031468	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031468
GO_process	GO:0036258	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036258
GO_process	GO:0039702	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0039702
GO_process	GO:0045324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045324
GO_process	GO:1904903	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1904903
GOslim_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007034	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007034
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0022607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
GeneCards	CHMP7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CHMP7
GeneID	91782	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=91782
GeneTree	ENSGT00720000108860	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00720000108860
HGNC	HGNC:28439	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:28439
HOGENOM	HOG000290682	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000290682&db=HOGENOM6
HOVERGEN	HBG081151	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG081151&db=HOVERGEN
HPA	HPA036119	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA036119
InParanoid	Q8WUX9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8WUX9
IntAct	Q8WUX9	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8WUX9*
InterPro	IPR005024	http://www.ebi.ac.uk/interpro/entry/IPR005024
Jabion	91782	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=91782
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Gene	hsa:91782	http://www.genome.jp/dbget-bin/www_bget?hsa:91782
KEGG_Orthology	KO:K15053	http://www.genome.jp/dbget-bin/www_bget?KO:K15053
KEGG_Pathway	ko04144	http://www.genome.jp/kegg-bin/show_pathway?ko04144
MIM	611130	http://www.ncbi.nlm.nih.gov/omim/611130
MINT	MINT-1460844	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1460844
OMA	MAKTYLR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MAKTYLR
OrthoDB	EOG091G09H0	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G09H0
PSORT	swissprot:CHMP7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CHMP7_HUMAN
PSORT-B	swissprot:CHMP7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CHMP7_HUMAN
PSORT2	swissprot:CHMP7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CHMP7_HUMAN
Pfam	PF03357	http://pfam.xfam.org/family/PF03357
PharmGKB	PA142672115	http://www.pharmgkb.org/do/serve?objId=PA142672115&objCls=Gene
Phobius	swissprot:CHMP7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CHMP7_HUMAN
PhylomeDB	Q8WUX9	http://phylomedb.org/?seqid=Q8WUX9
ProteinModelPortal	Q8WUX9	http://www.proteinmodelportal.org/query/uniprot/Q8WUX9
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16421571	http://www.ncbi.nlm.nih.gov/pubmed/16421571
PubMed	16856878	http://www.ncbi.nlm.nih.gov/pubmed/16856878
PubMed	16964243	http://www.ncbi.nlm.nih.gov/pubmed/16964243
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	26040712	http://www.ncbi.nlm.nih.gov/pubmed/26040712
Reactome	R-HSA-162588	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-162588
Reactome	R-HSA-1632852	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1632852
Reactome	R-HSA-917729	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917729
RefSeq	NP_689485	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_689485
SMR	Q8WUX9	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8WUX9
STRING	9606.ENSP00000324491	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000324491&targetmode=cogs
UCSC	uc003xdc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003xdc&org=rat
UniGene	Hs.5019	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.5019
UniProtKB	CHMP7_HUMAN	http://www.uniprot.org/uniprot/CHMP7_HUMAN
UniProtKB-AC	Q8WUX9	http://www.uniprot.org/uniprot/Q8WUX9
charge	swissprot:CHMP7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CHMP7_HUMAN
eggNOG	ENOG4110IXB	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110IXB
eggNOG	KOG2911	http://eggnogapi.embl.de/nog_data/html/tree/KOG2911
epestfind	swissprot:CHMP7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CHMP7_HUMAN
garnier	swissprot:CHMP7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CHMP7_HUMAN
helixturnhelix	swissprot:CHMP7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CHMP7_HUMAN
hmoment	swissprot:CHMP7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CHMP7_HUMAN
iep	swissprot:CHMP7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CHMP7_HUMAN
inforesidue	swissprot:CHMP7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CHMP7_HUMAN
neXtProt	NX_Q8WUX9	http://www.nextprot.org/db/entry/NX_Q8WUX9
octanol	swissprot:CHMP7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CHMP7_HUMAN
pepcoil	swissprot:CHMP7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CHMP7_HUMAN
pepdigest	swissprot:CHMP7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CHMP7_HUMAN
pepinfo	swissprot:CHMP7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CHMP7_HUMAN
pepnet	swissprot:CHMP7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CHMP7_HUMAN
pepstats	swissprot:CHMP7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CHMP7_HUMAN
pepwheel	swissprot:CHMP7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CHMP7_HUMAN
pepwindow	swissprot:CHMP7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CHMP7_HUMAN
sigcleave	swissprot:CHMP7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CHMP7_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ABCCD_HUMAN	Event=Alternative splicing; Named isoforms=5; Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; Synonyms=A; IsoId=Q9NSE7-1; Sequence=Displayed; Name=2; IsoId=Q9NSE7-2; Sequence=VSP_000066; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; Synonyms=B; IsoId=Q9NSE7-3; Sequence=VSP_000067; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=4; Synonyms=D; IsoId=Q9NSE7-4; Sequence=VSP_012455, VSP_012456; Name=5; Synonyms=C; IsoId=Q9NSE7-5; Sequence=VSP_012454; 
# CAUTION	Contains sequences related to the ABC transporters of subfamily C, but lacks Walker A, Walker B, and signature C motifs, indicating that it is a nonfunctional ABC transporter. Translation of the cDNA in a different reading frame predicts a 93 amino acid peptide with signature C and Walker B motifs, but no Walker A motif. {ECO	0000305}. 
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005524	ATP binding; IEA:InterPro.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# HGNC	HGNC:16022	ABCC13
# INDUCTION	Down-regulated by cell differentiation in certain leukemia cells. {ECO:0000269|PubMed	12445816}. 
# InterPro	IPR011527	ABC1_TM_dom
# MIM	608835	gene
# Organism	ABCCD_HUMAN	Homo sapiens (Human)
# PIR	JC7909	JC7909
# PROSITE	PS50929	ABC_TM1F
# Pfam	PF00664	ABC_membrane
# Proteomes	UP000005640	Unplaced
# RecName	ABCCD_HUMAN	Putative ATP-binding cassette sub-family C member 13
# SIMILARITY	Belongs to the binding-protein-dependent transport system permease family. {ECO	0000305}. 
# SIMILARITY	Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule	PRU00441}. 
# SUBCELLULAR LOCATION	ABCCD_HUMAN	Membrane {ECO 0000255|PROSITE- ProRule PRU00441}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00441}. 
# SUPFAM	SSF90123	SSF90123
# TISSUE SPECIFICITY	ABCCD_HUMAN	Highest expression in fetal liver and fetal spleen. In the adult, highest levels are found in the colon ascending and transverse. Also expressed in brain, placenta, lung, liver, pancreas and ovary. In bone marrow cells, levels are several fold higher than in peripheral blood leukocytes. {ECO 0000269|PubMed 12036298, ECO 0000269|PubMed 12445816, ECO 0000269|PubMed 15203202}. 
# WEB RESOURCE	ABCCD_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=Q9NSE7";
BLAST	swissprot:ABCCD_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCCD_HUMAN
BioCyc	ZFISH:G66-33729-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33729-MONOMER
CleanEx	HS_ABCC13	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCC13
DOI	10.1006/geno.2002.6782	http://dx.doi.org/10.1006/geno.2002.6782
DOI	10.1016/S0006-291X(02)02658-X	http://dx.doi.org/10.1016/S0006-291X(02)02658-X
DOI	10.1016/S0378-1119(03)00530-4	http://dx.doi.org/10.1016/S0378-1119(03)00530-4
DOI	10.1016/j.ygeno.2004.02.010	http://dx.doi.org/10.1016/j.ygeno.2004.02.010
DOI	10.1038/35012518	http://dx.doi.org/10.1038/35012518
DOI	10.1186/gb-2004-5-2-r8	http://dx.doi.org/10.1186/gb-2004-5-2-r8
EMBL	AF418600	http://www.ebi.ac.uk/ena/data/view/AF418600
EMBL	AF518320	http://www.ebi.ac.uk/ena/data/view/AF518320
EMBL	AF518321	http://www.ebi.ac.uk/ena/data/view/AF518321
EMBL	AP001660	http://www.ebi.ac.uk/ena/data/view/AP001660
EMBL	AY063514	http://www.ebi.ac.uk/ena/data/view/AY063514
EMBL	AY063515	http://www.ebi.ac.uk/ena/data/view/AY063515
EMBL	AY344117	http://www.ebi.ac.uk/ena/data/view/AY344117
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GeneCards	ABCC13	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCC13
HGNC	HGNC:16022	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16022
InParanoid	Q9NSE7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NSE7
InterPro	IPR011527	http://www.ebi.ac.uk/interpro/entry/IPR011527
MIM	608835	http://www.ncbi.nlm.nih.gov/omim/608835
PROSITE	PS50929	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929
PSORT	swissprot:ABCCD_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCCD_HUMAN
PSORT-B	swissprot:ABCCD_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCCD_HUMAN
PSORT2	swissprot:ABCCD_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCCD_HUMAN
Pfam	PF00664	http://pfam.xfam.org/family/PF00664
Phobius	swissprot:ABCCD_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCCD_HUMAN
PhylomeDB	Q9NSE7	http://phylomedb.org/?seqid=Q9NSE7
ProteinModelPortal	Q9NSE7	http://www.proteinmodelportal.org/query/uniprot/Q9NSE7
PubMed	10830953	http://www.ncbi.nlm.nih.gov/pubmed/10830953
PubMed	12036298	http://www.ncbi.nlm.nih.gov/pubmed/12036298
PubMed	12445816	http://www.ncbi.nlm.nih.gov/pubmed/12445816
PubMed	12909339	http://www.ncbi.nlm.nih.gov/pubmed/12909339
PubMed	14759258	http://www.ncbi.nlm.nih.gov/pubmed/14759258
PubMed	15203202	http://www.ncbi.nlm.nih.gov/pubmed/15203202
SMR	Q9NSE7	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9NSE7
SUPFAM	SSF90123	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123
UniGene	Hs.366575	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.366575
UniProtKB	ABCCD_HUMAN	http://www.uniprot.org/uniprot/ABCCD_HUMAN
UniProtKB-AC	Q9NSE7	http://www.uniprot.org/uniprot/Q9NSE7
charge	swissprot:ABCCD_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCCD_HUMAN
epestfind	swissprot:ABCCD_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCCD_HUMAN
garnier	swissprot:ABCCD_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCCD_HUMAN
helixturnhelix	swissprot:ABCCD_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCCD_HUMAN
hmoment	swissprot:ABCCD_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCCD_HUMAN
iep	swissprot:ABCCD_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCCD_HUMAN
inforesidue	swissprot:ABCCD_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCCD_HUMAN
neXtProt	NX_Q9NSE7	http://www.nextprot.org/db/entry/NX_Q9NSE7
octanol	swissprot:ABCCD_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCCD_HUMAN
pepcoil	swissprot:ABCCD_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCCD_HUMAN
pepdigest	swissprot:ABCCD_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCCD_HUMAN
pepinfo	swissprot:ABCCD_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCCD_HUMAN
pepnet	swissprot:ABCCD_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCCD_HUMAN
pepstats	swissprot:ABCCD_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCCD_HUMAN
pepwheel	swissprot:ABCCD_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCCD_HUMAN
pepwindow	swissprot:ABCCD_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCCD_HUMAN
sigcleave	swissprot:ABCCD_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCCD_HUMAN
## Database	ID	URL or Descriptions
# AltName	TRPA1_HUMAN	Ankyrin-like with transmembrane domains protein 1
# AltName	TRPA1_HUMAN	Transformation-sensitive protein p120
# DISEASE	TRPA1_HUMAN	Episodic pain syndrome, familial, 1 (FEPS1) [MIM 615040]  An autosomal dominant neurologic disorder characterized by onset in infancy of episodic debilitating upper body pain triggered by fasting, cold, and physical stress. The period of intense pain is accompanied by breathing difficulties, tachycardia, sweating, generalized pallor, peribuccal cyanosis, and stiffness of the abdominal wall. Affected individuals do not manifest altered pain sensitivity outside the episodes. {ECO 0000269|PubMed 20547126}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	TRPA1_HUMAN	C-terminal helices from the four subunits associate to form atypical coiled coil structure; this region is probably involved in binding the inositol polyphosphates that are required for optimal channel activity (in vitro). {ECO 0000305|PubMed 25855297}. 
# DOMAIN	TRPA1_HUMAN	The ANK repeat domain consists of a convex stem structure formed by five ANK repeats and 11 additional ANK repeats that form a crescent-shaped structure that surrounds the protein core. {ECO 0000269|PubMed 25855297}. 
# DrugBank	DB00825	Menthol
# ENZYME REGULATION	Inhibited by ruthenium red, a potent blocker of TRPV channels. {ECO:0000269|PubMed	20547126}. 
# Ensembl	ENST00000262209	ENSP00000262209; ENSG00000104321
# ExpressionAtlas	O75762	baseline and differential
# FUNCTION	TRPA1_HUMAN	Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function (PubMed 25389312, PubMed 25855297). Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, cinnamaldehyde, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes (PubMed 25389312, PubMed 20547126). Is also activated by menthol (in vitro)(PubMed 25389312). Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed 25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity). {ECO 0000250|UniProtKB Q8BLA8, ECO 0000269|PubMed 20547126, ECO 0000269|PubMed 25389312, ECO 0000269|PubMed 25855297}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IMP:UniProtKB.
# GO_component	GO:0032421	stereocilium bundle; IEA:Ensembl.
# GO_function	GO:0005262	calcium channel activity; TAS:Reactome.
# GO_function	GO:0015267	channel activity; TAS:ProtInc.
# GO_function	GO:0015278	calcium-release channel activity; IDA:UniProtKB.
# GO_function	GO:0097604	temperature-gated cation channel activity; IDA:UniProtKB.
# GO_process	GO:0006811	ion transport; TAS:ProtInc.
# GO_process	GO:0007166	cell surface receptor signaling pathway; IEA:Ensembl.
# GO_process	GO:0009409	response to cold; IEA:Ensembl.
# GO_process	GO:0010033	response to organic substance; IMP:UniProtKB.
# GO_process	GO:0014070	response to organic cyclic compound; IEA:Ensembl.
# GO_process	GO:0019233	sensory perception of pain; IMP:UniProtKB.
# GO_process	GO:0042493	response to drug; IEA:Ensembl.
# GO_process	GO:0042542	response to hydrogen peroxide; IEA:Ensembl.
# GO_process	GO:0048265	response to pain; IEA:Ensembl.
# GO_process	GO:0050955	thermoception; IEA:Ensembl.
# GO_process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain; IEA:Ensembl.
# GO_process	GO:0050968	detection of chemical stimulus involved in sensory perception of pain; IEA:Ensembl.
# GO_process	GO:0051289	protein homotetramerization; IDA:UniProtKB.
# GO_process	GO:0070588	calcium ion transmembrane transport; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.25.40.20	-; 4.
# Genevisible	O75762	HS
# HGNC	HGNC:497	TRPA1
# IntAct	O75762	2
# InterPro	IPR002110	Ankyrin_rpt
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR020683	Ankyrin_rpt-contain_dom
# KEGG_Brite	ko04040	Ion channels
# KEGG_Disease	H01391	[Nervous system disease] Familial episodic pain syndrome (FEPS)
# MIM	604775	gene
# MIM	615040	phenotype
# Organism	TRPA1_HUMAN	Homo sapiens (Human)
# Orphanet	391389	Familial episodic pain syndrome with predominantly upper body involvement
# PDB	3J9P	EM; 4.24 A; A/B/C/D=2-1119
# PRINTS	PR01415	ANKYRIN
# PROSITE	PS50088	ANK_REPEAT; 9
# PROSITE	PS50297	ANK_REP_REGION
# PTM	TRPA1_HUMAN	TRPA1 activation by electrophiles occurs though covalent modification of specific cysteine residues in the N-terminal cytoplasmic domain. {ECO 0000305|PubMed 25389312}. 
# Pfam	PF00520	Ion_trans
# Pfam	PF12796	Ank_2; 6
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-3295583	TRP channels
# RecName	TRPA1_HUMAN	Transient receptor potential cation channel subfamily A member 1
# RefSeq	NP_015628	NM_007332.2
# RefSeq	XP_011515927	XM_011517625.2
# RefSeq	XP_016869435	XM_017013946.1
# SIMILARITY	Belongs to the transient receptor (TC 1.A.4) family. {ECO	0000305}. 
# SIMILARITY	TRPA1_HUMAN	Contains 16 ANK repeats. {ECO 0000255|PROSITE- ProRule PRU00023, ECO 0000305|PubMed 25855297}. 
# SMART	SM00248	ANK; 14
# SUBCELLULAR LOCATION	TRPA1_HUMAN	Cell membrane {ECO 0000269|PubMed 20547126, ECO 0000269|PubMed 25389312, ECO 0000269|PubMed 25855297}; Multi- pass membrane protein {ECO 0000305}. 
# SUBUNIT	TRPA1_HUMAN	Homotetramer (PubMed 25389312, PubMed 25855297). Interacts with TMEM100 (By similarity). {ECO 0000250|UniProtKB Q8BLA8, ECO 0000269|PubMed 25389312, ECO 0000269|PubMed 25855297}. 
# SUPFAM	SSF48403	SSF48403; 2
# TCDB	1.A.4.6	the transient receptor potential ca(2+) channel (trp-cc) family
# TISSUE SPECIFICITY	Expressed at very low level. Expressed at very low level in human fibroblasts and at a moderate level in liposarcoma cells. {ECO:0000269|PubMed	10066796}. 
# UCSC	uc003xza	human
# WEB RESOURCE	TRPA1_HUMAN	Name=Protein Spotlight; Note=The power behind pain - Issue 82 of May 2007; URL="http //web.expasy.org/spotlight/back_issues/082";
# eggNOG	COG0666	LUCA
# eggNOG	KOG0510	Eukaryota
BLAST	swissprot:TRPA1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TRPA1_HUMAN
BioCyc	ZFISH:ENSG00000104321-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000104321-MONOMER
COXPRESdb	8989	http://coxpresdb.jp/data/gene/8989.shtml
CleanEx	HS_TRPA1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TRPA1
DIP	DIP-61520N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-61520N
DOI	10.1016/j.neuron.2010.04.030	http://dx.doi.org/10.1016/j.neuron.2010.04.030
DOI	10.1038/nature04406	http://dx.doi.org/10.1038/nature04406
DOI	10.1038/nature14367	http://dx.doi.org/10.1038/nature14367
DOI	10.1073/pnas.1412689111	http://dx.doi.org/10.1073/pnas.1412689111
DOI	10.1074/jbc.274.11.7325	http://dx.doi.org/10.1074/jbc.274.11.7325
DrugBank	DB00825	http://www.drugbank.ca/drugs/DB00825
EMBL	AC022867	http://www.ebi.ac.uk/ena/data/view/AC022867
EMBL	Y10601	http://www.ebi.ac.uk/ena/data/view/Y10601
Ensembl	ENST00000262209	http://www.ensembl.org/id/ENST00000262209
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0032421	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032421
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0015267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015267
GO_function	GO:0015278	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015278
GO_function	GO:0097604	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097604
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0007166	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007166
GO_process	GO:0009409	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009409
GO_process	GO:0010033	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010033
GO_process	GO:0014070	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014070
GO_process	GO:0019233	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019233
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0042542	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042542
GO_process	GO:0048265	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048265
GO_process	GO:0050955	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050955
GO_process	GO:0050966	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050966
GO_process	GO:0050968	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050968
GO_process	GO:0051289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051289
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.25.40.20	http://www.cathdb.info/version/latest/superfamily/1.25.40.20
GeneCards	TRPA1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TRPA1
GeneID	8989	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8989
GeneTree	ENSGT00850000132305	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00850000132305
H-InvDB	HIX0034373	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0034373
H-InvDB	HIX0124652	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0124652
HGNC	HGNC:497	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:497
HOGENOM	HOG000044486	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000044486&db=HOGENOM6
HOVERGEN	HBG059027	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG059027&db=HOVERGEN
HPA	HPA026630	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA026630
InParanoid	O75762	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O75762
IntAct	O75762	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O75762*
InterPro	IPR002110	http://www.ebi.ac.uk/interpro/entry/IPR002110
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR020683	http://www.ebi.ac.uk/interpro/entry/IPR020683
Jabion	8989	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=8989
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H01391	http://www.genome.jp/dbget-bin/www_bget?H01391
KEGG_Gene	hsa:8989	http://www.genome.jp/dbget-bin/www_bget?hsa:8989
KEGG_Orthology	KO:K04984	http://www.genome.jp/dbget-bin/www_bget?KO:K04984
MIM	604775	http://www.ncbi.nlm.nih.gov/omim/604775
MIM	615040	http://www.ncbi.nlm.nih.gov/omim/615040
OMA	WLAYGFR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WLAYGFR
Orphanet	391389	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=391389
OrthoDB	EOG091G01BG	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01BG
PDB	3J9P	http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9P
PDBsum	3J9P	http://www.ebi.ac.uk/pdbsum/3J9P
PRINTS	PR01415	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01415
PROSITE	PS50088	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50088
PROSITE	PS50297	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50297
PSORT	swissprot:TRPA1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TRPA1_HUMAN
PSORT-B	swissprot:TRPA1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TRPA1_HUMAN
PSORT2	swissprot:TRPA1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TRPA1_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF12796	http://pfam.xfam.org/family/PF12796
Phobius	swissprot:TRPA1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TRPA1_HUMAN
PhylomeDB	O75762	http://phylomedb.org/?seqid=O75762
ProteinModelPortal	O75762	http://www.proteinmodelportal.org/query/uniprot/O75762
PubMed	10066796	http://www.ncbi.nlm.nih.gov/pubmed/10066796
PubMed	16421571	http://www.ncbi.nlm.nih.gov/pubmed/16421571
PubMed	20547126	http://www.ncbi.nlm.nih.gov/pubmed/20547126
PubMed	25389312	http://www.ncbi.nlm.nih.gov/pubmed/25389312
PubMed	25855297	http://www.ncbi.nlm.nih.gov/pubmed/25855297
Reactome	R-HSA-3295583	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3295583
RefSeq	NP_015628	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_015628
RefSeq	XP_011515927	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011515927
RefSeq	XP_016869435	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016869435
SMART	SM00248	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00248
SMR	O75762	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O75762
STRING	9606.ENSP00000262209	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000262209&targetmode=cogs
SUPFAM	SSF48403	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48403
TCDB	1.A.4.6	http://www.tcdb.org/search/result.php?tc=1.A.4.6
UCSC	uc003xza	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003xza&org=rat
UniGene	Hs.716816	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.716816
UniProtKB	TRPA1_HUMAN	http://www.uniprot.org/uniprot/TRPA1_HUMAN
UniProtKB-AC	O75762	http://www.uniprot.org/uniprot/O75762
charge	swissprot:TRPA1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TRPA1_HUMAN
eggNOG	COG0666	http://eggnogapi.embl.de/nog_data/html/tree/COG0666
eggNOG	KOG0510	http://eggnogapi.embl.de/nog_data/html/tree/KOG0510
epestfind	swissprot:TRPA1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TRPA1_HUMAN
garnier	swissprot:TRPA1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TRPA1_HUMAN
helixturnhelix	swissprot:TRPA1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRPA1_HUMAN
hmoment	swissprot:TRPA1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TRPA1_HUMAN
iep	swissprot:TRPA1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TRPA1_HUMAN
inforesidue	swissprot:TRPA1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TRPA1_HUMAN
neXtProt	NX_O75762	http://www.nextprot.org/db/entry/NX_O75762
octanol	swissprot:TRPA1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TRPA1_HUMAN
pepcoil	swissprot:TRPA1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TRPA1_HUMAN
pepdigest	swissprot:TRPA1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TRPA1_HUMAN
pepinfo	swissprot:TRPA1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TRPA1_HUMAN
pepnet	swissprot:TRPA1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TRPA1_HUMAN
pepstats	swissprot:TRPA1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TRPA1_HUMAN
pepwheel	swissprot:TRPA1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TRPA1_HUMAN
pepwindow	swissprot:TRPA1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TRPA1_HUMAN
sigcleave	swissprot:TRPA1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TRPA1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GRIK2_HUMAN	Event=Alternative splicing; Named isoforms=7; Name=1; Synonyms=A; IsoId=Q13002-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q13002-2; Sequence=VSP_022335; Name=3; IsoId=Q13002-3; Sequence=VSP_022337; Name=4; IsoId=Q13002-4; Sequence=VSP_022334; Name=5; Synonyms=C; IsoId=Q13002-5; Sequence=VSP_022336; Name=6; Synonyms=D; IsoId=Q13002-6; Sequence=VSP_044388, VSP_022335; Note=Seems to be specific for non-neuronal cells. May not function as active channel.; Name=7; Synonyms=E; IsoId=Q13002-7; Sequence=VSP_044389, VSP_022336; Note=Seems to be specific for non-neuronal cells. May not function as active channel.; 
# AltName	GRIK2_HUMAN	Excitatory amino acid receptor 4
# AltName	GRIK2_HUMAN	Glutamate receptor 6
# BioGrid	109155	13
# CCDS	CCDS5048	-. [Q13002-1]
# CCDS	CCDS5049	-. [Q13002-2]
# CCDS	CCDS55045	-. [Q13002-5]
# DISEASE	GRIK2_HUMAN	Mental retardation, autosomal recessive 6 (MRT6) [MIM 611092]  A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. In contrast to syndromic or specific mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic mental retardation. MRT6 patients display mild to severe mental retardation and psychomotor development delay in early childhood. Patients do not have neurologic problems, congenital malformations, or facial dysmorphism. Body height, weight, and head circumference are normal. {ECO 0000269|PubMed 17847003}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00237	Butabarbital
# DrugBank	DB00241	Butalbital
# DrugBank	DB00306	Talbutal
# DrugBank	DB00312	Pentobarbital
# DrugBank	DB00418	Secobarbital
# DrugBank	DB00599	Thiopental
# DrugBank	DB00794	Primidone
# DrugBank	DB00849	Methylphenobarbital
# DrugBank	DB01174	Phenobarbital
# DrugBank	DB01351	Amobarbital
# DrugBank	DB01352	Aprobarbital
# DrugBank	DB01353	Butethal
# DrugBank	DB01354	Heptabarbital
# DrugBank	DB01355	Hexobarbital
# Ensembl	ENST00000369138	ENSP00000358134; ENSG00000164418. [Q13002-5]
# Ensembl	ENST00000413795	ENSP00000405596; ENSG00000164418. [Q13002-2]
# Ensembl	ENST00000421544	ENSP00000397026; ENSG00000164418. [Q13002-1]
# ExpressionAtlas	Q13002	baseline and differential
# FUNCTION	GRIK2_HUMAN	Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity). {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0014069	postsynaptic density; IEA:Ensembl.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0032839	dendrite cytoplasm; IEA:Ensembl.
# GO_component	GO:0032983	kainate selective glutamate receptor complex; IEA:Ensembl.
# GO_component	GO:0042734	presynaptic membrane; IEA:Ensembl.
# GO_component	GO:0043195	terminal bouton; IEA:Ensembl.
# GO_component	GO:0043204	perikaryon; IEA:Ensembl.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0005234	extracellular-glutamate-gated ion channel activity; IEA:InterPro.
# GO_function	GO:0015276	ligand-gated ion channel activity; TAS:Reactome.
# GO_function	GO:0015277	kainate selective glutamate receptor activity; IDA:UniProtKB.
# GO_process	GO:0001662	behavioral fear response; IEA:Ensembl.
# GO_process	GO:0006810	transport; NAS:ProtInc.
# GO_process	GO:0006874	cellular calcium ion homeostasis; IEA:Ensembl.
# GO_process	GO:0006886	intracellular protein transport; IEA:Ensembl.
# GO_process	GO:0007215	glutamate receptor signaling pathway; TAS:ProtInc.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:ProtInc.
# GO_process	GO:0019228	neuronal action potential; IEA:Ensembl.
# GO_process	GO:0035249	synaptic transmission, glutamatergic; IEA:Ensembl.
# GO_process	GO:0043113	receptor clustering; IEA:Ensembl.
# GO_process	GO:0043524	negative regulation of neuron apoptotic process; IEA:Ensembl.
# GO_process	GO:0043525	positive regulation of neuron apoptotic process; IEA:Ensembl.
# GO_process	GO:0046328	regulation of JNK cascade; IEA:Ensembl.
# GO_process	GO:0048169	regulation of long-term neuronal synaptic plasticity; IEA:Ensembl.
# GO_process	GO:0048172	regulation of short-term neuronal synaptic plasticity; IMP:UniProtKB.
# GO_process	GO:0050804	modulation of synaptic transmission; IDA:UniProtKB.
# GO_process	GO:0050806	positive regulation of synaptic transmission; IMP:UniProtKB.
# GO_process	GO:0051402	neuron apoptotic process; IEA:Ensembl.
# GO_process	GO:0051967	negative regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
# GO_process	GO:0060079	excitatory postsynaptic potential; IEA:Ensembl.
# GO_process	GO:0060080	inhibitory postsynaptic potential; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0008219	cell death
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0061024	membrane organization
# Genevisible	Q13002	HS
# HGNC	HGNC:4580	GRIK2
# IntAct	Q13002	2
# InterPro	IPR001320	Iontro_rcpt
# InterPro	IPR001508	Iono_rcpt_met
# InterPro	IPR001828	ANF_lig-bd_rcpt
# InterPro	IPR019594	Glu/Gly-bd
# InterPro	IPR028082	Peripla_BP_I
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00768	[Congenital disorder; Mental retardation] Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04724	Glutamatergic synapse
# MIM	138244	gene
# MIM	611092	phenotype
# MISCELLANEOUS	GRIK2_HUMAN	The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate > quisqualate > 6- cyano-7-nitroquinoxaline-2,3-dione > L-glutamate = 6,7- dinitroquinoxaline-2,3-dione > dihydrokainate. 
# Organism	GRIK2_HUMAN	Homo sapiens (Human)
# Orphanet	88616	Autosomal recessive non-syndromic intellectual disability
# PDB	3QXM	X-ray; 1.65 A; A/B=429-544, A/B=667-806
# PDB	5CMM	X-ray; 1.27 A; A=667-806
# PIR	A54260	A54260
# PRINTS	PR00177	NMDARECEPTOR
# PTM	GRIK2_HUMAN	Phosphorylated by PKC at Ser-868 upon agonist activation, this directly enhance sumoylation. {ECO 0000269|PubMed 22808340}. 
# PTM	GRIK2_HUMAN	Sumoylation mediates kainate receptor-mediated endocytosis and regulates synaptic transmission. Sumoylation is enhanced by PIAS3 and desumoylated by SENP1 (By similarity). {ECO 0000250}. 
# PTM	GRIK2_HUMAN	Ubiquitinated. Ubiquitination regulates the GRIK2 levels at the synapse by leading kainate receptor degradation through proteasome (By similarity). {ECO 0000250}. 
# Pfam	PF00060	Lig_chan
# Pfam	PF01094	ANF_receptor
# Pfam	PF10613	Lig_chan-Glu_bd
# Proteomes	UP000005640	Chromosome 6
# RNA EDITING	GRIK2_HUMAN	Modified_positions=567 {ECO 0000269|PubMed 7696618}, 571 {ECO 0000269|PubMed 7696618}, 621 {ECO 0000269|PubMed 7523595, ECO 0000269|PubMed 7696618}; Note=Partially edited. The presence of Gln at position 621 (non-edited) determines channels with low calcium permeability, whereas Arg (edited) determines a higher calcium permeability especially if the preceding sites are fully edited. This receptor is nearly completely edited in all gray matter structures (90% of the receptors), whereas much less edited in the white matter (10% of the receptors).; 
# Reactome	R-HSA-451307	Activation of Na-permeable Kainate Receptors
# Reactome	R-HSA-451308	Activation of Ca-permeable Kainate Receptor
# RecName	GRIK2_HUMAN	Glutamate receptor ionotropic, kainate 2
# RefSeq	NP_001159719	NM_001166247.1. [Q13002-5]
# RefSeq	NP_068775	NM_021956.4. [Q13002-1]
# RefSeq	NP_786944	NM_175768.3. [Q13002-2]
# RefSeq	XP_005267002	XM_005266945.2. [Q13002-1]
# RefSeq	XP_011534079	XM_011535777.2. [Q13002-5]
# RefSeq	XP_011534080	XM_011535778.2. [Q13002-2]
# SIMILARITY	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK2 subfamily. {ECO	0000305}.
# SMART	SM00079	PBPe
# SMART	SM00918	Lig_chan-Glu_bd
# SUBCELLULAR LOCATION	GRIK2_HUMAN	Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers (Probable). Assembles into a kainate-gated homomeric channel that does not bind AMPA. GRIK2 associated to GRIK5 forms functional channels that can be gated by AMPA (By similarity). Interacts with DLG4. Interacts with NETO2 (By similarity). Interacts (via C-terminus) with KLHL17 (via kelch repeats); the interaction targets GRIK2 for degradation via ubiquitin-proteasome pathway (By similarity). {ECO:0000250, ECO	0000305}. 
# SUPFAM	SSF53822	SSF53822
# TISSUE SPECIFICITY	GRIK2_HUMAN	Expression is higher in cerebellum than in cerebral cortex. 
# UCSC	uc003pqo	human. [Q13002-1]
# eggNOG	ENOG410XPSH	LUCA
# eggNOG	KOG1054	Eukaryota
BLAST	swissprot:GRIK2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GRIK2_HUMAN
COXPRESdb	2898	http://coxpresdb.jp/data/gene/2898.shtml
CleanEx	HS_GRIK2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GRIK2
DOI	10.1006/geno.1994.1198	http://dx.doi.org/10.1006/geno.1994.1198
DOI	10.1016/S0378-1119(01)00611-4	http://dx.doi.org/10.1016/S0378-1119(01)00611-4
DOI	10.1016/j.gene.2010.03.002	http://dx.doi.org/10.1016/j.gene.2010.03.002
DOI	10.1016/j.jmb.2011.08.043	http://dx.doi.org/10.1016/j.jmb.2011.08.043
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1074/jbc.M109453200	http://dx.doi.org/10.1074/jbc.M109453200
DOI	10.1086/521275	http://dx.doi.org/10.1086/521275
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.4161/cib.19195	http://dx.doi.org/10.4161/cib.19195
DrugBank	DB00237	http://www.drugbank.ca/drugs/DB00237
DrugBank	DB00241	http://www.drugbank.ca/drugs/DB00241
DrugBank	DB00306	http://www.drugbank.ca/drugs/DB00306
DrugBank	DB00312	http://www.drugbank.ca/drugs/DB00312
DrugBank	DB00418	http://www.drugbank.ca/drugs/DB00418
DrugBank	DB00599	http://www.drugbank.ca/drugs/DB00599
DrugBank	DB00794	http://www.drugbank.ca/drugs/DB00794
DrugBank	DB00849	http://www.drugbank.ca/drugs/DB00849
DrugBank	DB01174	http://www.drugbank.ca/drugs/DB01174
DrugBank	DB01351	http://www.drugbank.ca/drugs/DB01351
DrugBank	DB01352	http://www.drugbank.ca/drugs/DB01352
DrugBank	DB01353	http://www.drugbank.ca/drugs/DB01353
DrugBank	DB01354	http://www.drugbank.ca/drugs/DB01354
DrugBank	DB01355	http://www.drugbank.ca/drugs/DB01355
EMBL	AJ252246	http://www.ebi.ac.uk/ena/data/view/AJ252246
EMBL	AJ301608	http://www.ebi.ac.uk/ena/data/view/AJ301608
EMBL	AJ301609	http://www.ebi.ac.uk/ena/data/view/AJ301609
EMBL	AJ301610	http://www.ebi.ac.uk/ena/data/view/AJ301610
EMBL	AL109919	http://www.ebi.ac.uk/ena/data/view/AL109919
EMBL	AP002528	http://www.ebi.ac.uk/ena/data/view/AP002528
EMBL	AP002529	http://www.ebi.ac.uk/ena/data/view/AP002529
EMBL	AP002530	http://www.ebi.ac.uk/ena/data/view/AP002530
EMBL	CH471051	http://www.ebi.ac.uk/ena/data/view/CH471051
EMBL	HM149335	http://www.ebi.ac.uk/ena/data/view/HM149335
EMBL	HM149336	http://www.ebi.ac.uk/ena/data/view/HM149336
EMBL	HM149337	http://www.ebi.ac.uk/ena/data/view/HM149337
EMBL	HM149338	http://www.ebi.ac.uk/ena/data/view/HM149338
EMBL	HM149339	http://www.ebi.ac.uk/ena/data/view/HM149339
EMBL	U16126	http://www.ebi.ac.uk/ena/data/view/U16126
Ensembl	ENST00000369138	http://www.ensembl.org/id/ENST00000369138
Ensembl	ENST00000413795	http://www.ensembl.org/id/ENST00000413795
Ensembl	ENST00000421544	http://www.ensembl.org/id/ENST00000421544
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0014069	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014069
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0032839	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032839
GO_component	GO:0032983	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032983
GO_component	GO:0042734	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042734
GO_component	GO:0043195	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043195
GO_component	GO:0043204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043204
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0005234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005234
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_function	GO:0015277	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015277
GO_process	GO:0001662	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001662
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874
GO_process	GO:0006886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006886
GO_process	GO:0007215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007215
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0019228	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019228
GO_process	GO:0035249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035249
GO_process	GO:0043113	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043113
GO_process	GO:0043524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043524
GO_process	GO:0043525	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043525
GO_process	GO:0046328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046328
GO_process	GO:0048169	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048169
GO_process	GO:0048172	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048172
GO_process	GO:0050804	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050804
GO_process	GO:0050806	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050806
GO_process	GO:0051402	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051402
GO_process	GO:0051967	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051967
GO_process	GO:0060079	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060079
GO_process	GO:0060080	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060080
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0008219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
GeneCards	GRIK2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GRIK2
GeneID	2898	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2898
GeneTree	ENSGT00760000118920	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118920
H-InvDB	HIX0006094	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0006094
HGNC	HGNC:4580	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4580
HOGENOM	HOG000234371	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234371&db=HOGENOM6
HOVERGEN	HBG051839	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051839&db=HOVERGEN
HPA	CAB022463	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB022463
HPA	HPA014395	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014395
HPA	HPA014623	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014623
InParanoid	Q13002	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q13002
IntAct	Q13002	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q13002*
InterPro	IPR001320	http://www.ebi.ac.uk/interpro/entry/IPR001320
InterPro	IPR001508	http://www.ebi.ac.uk/interpro/entry/IPR001508
InterPro	IPR001828	http://www.ebi.ac.uk/interpro/entry/IPR001828
InterPro	IPR019594	http://www.ebi.ac.uk/interpro/entry/IPR019594
InterPro	IPR028082	http://www.ebi.ac.uk/interpro/entry/IPR028082
Jabion	2898	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2898
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00768	http://www.genome.jp/dbget-bin/www_bget?H00768
KEGG_Gene	hsa:2898	http://www.genome.jp/dbget-bin/www_bget?hsa:2898
KEGG_Orthology	KO:K05202	http://www.genome.jp/dbget-bin/www_bget?KO:K05202
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
MIM	138244	http://www.ncbi.nlm.nih.gov/omim/138244
MIM	611092	http://www.ncbi.nlm.nih.gov/omim/611092
OMA	VFRCTIR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VFRCTIR
Orphanet	88616	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=88616
OrthoDB	EOG091G02LN	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02LN
PDB	3QXM	http://www.ebi.ac.uk/pdbe-srv/view/entry/3QXM
PDB	5CMM	http://www.ebi.ac.uk/pdbe-srv/view/entry/5CMM
PDBsum	3QXM	http://www.ebi.ac.uk/pdbsum/3QXM
PDBsum	5CMM	http://www.ebi.ac.uk/pdbsum/5CMM
PRINTS	PR00177	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00177
PSORT	swissprot:GRIK2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GRIK2_HUMAN
PSORT-B	swissprot:GRIK2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GRIK2_HUMAN
PSORT2	swissprot:GRIK2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GRIK2_HUMAN
Pfam	PF00060	http://pfam.xfam.org/family/PF00060
Pfam	PF01094	http://pfam.xfam.org/family/PF01094
Pfam	PF10613	http://pfam.xfam.org/family/PF10613
PharmGKB	PA164741600	http://www.pharmgkb.org/do/serve?objId=PA164741600&objCls=Gene
Phobius	swissprot:GRIK2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GRIK2_HUMAN
PhylomeDB	Q13002	http://phylomedb.org/?seqid=Q13002
ProteinModelPortal	Q13002	http://www.proteinmodelportal.org/query/uniprot/Q13002
PubMed	11675011	http://www.ncbi.nlm.nih.gov/pubmed/11675011
PubMed	11744724	http://www.ncbi.nlm.nih.gov/pubmed/11744724
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	17847003	http://www.ncbi.nlm.nih.gov/pubmed/17847003
PubMed	20230879	http://www.ncbi.nlm.nih.gov/pubmed/20230879
PubMed	21893069	http://www.ncbi.nlm.nih.gov/pubmed/21893069
PubMed	22808340	http://www.ncbi.nlm.nih.gov/pubmed/22808340
PubMed	7523595	http://www.ncbi.nlm.nih.gov/pubmed/7523595
PubMed	7536611	http://www.ncbi.nlm.nih.gov/pubmed/7536611
PubMed	7696618	http://www.ncbi.nlm.nih.gov/pubmed/7696618
PubMed	8034316	http://www.ncbi.nlm.nih.gov/pubmed/8034316
Reactome	R-HSA-451307	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-451307
Reactome	R-HSA-451308	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-451308
RefSeq	NP_001159719	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001159719
RefSeq	NP_068775	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_068775
RefSeq	NP_786944	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_786944
RefSeq	XP_005267002	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005267002
RefSeq	XP_011534079	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011534079
RefSeq	XP_011534080	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011534080
SMART	SM00079	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00079
SMART	SM00918	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00918
SMR	Q13002	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q13002
STRING	9606.ENSP00000397026	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000397026&targetmode=cogs
SUPFAM	SSF53822	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822
UCSC	uc003pqo	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003pqo&org=rat
UniGene	Hs.98262	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.98262
UniProtKB	GRIK2_HUMAN	http://www.uniprot.org/uniprot/GRIK2_HUMAN
UniProtKB-AC	Q13002	http://www.uniprot.org/uniprot/Q13002
charge	swissprot:GRIK2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GRIK2_HUMAN
eggNOG	ENOG410XPSH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPSH
eggNOG	KOG1054	http://eggnogapi.embl.de/nog_data/html/tree/KOG1054
epestfind	swissprot:GRIK2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GRIK2_HUMAN
garnier	swissprot:GRIK2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GRIK2_HUMAN
helixturnhelix	swissprot:GRIK2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GRIK2_HUMAN
hmoment	swissprot:GRIK2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GRIK2_HUMAN
iep	swissprot:GRIK2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GRIK2_HUMAN
inforesidue	swissprot:GRIK2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GRIK2_HUMAN
neXtProt	NX_Q13002	http://www.nextprot.org/db/entry/NX_Q13002
octanol	swissprot:GRIK2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GRIK2_HUMAN
pepcoil	swissprot:GRIK2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GRIK2_HUMAN
pepdigest	swissprot:GRIK2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GRIK2_HUMAN
pepinfo	swissprot:GRIK2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GRIK2_HUMAN
pepnet	swissprot:GRIK2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GRIK2_HUMAN
pepstats	swissprot:GRIK2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GRIK2_HUMAN
pepwheel	swissprot:GRIK2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GRIK2_HUMAN
pepwindow	swissprot:GRIK2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GRIK2_HUMAN
sigcleave	swissprot:GRIK2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GRIK2_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCAB3_HUMAN	K(+) channel subunit beta-3
# AltName	KCAB3_HUMAN	Kv-beta-3
# BioGrid	114631	7
# CDD	cd06660	Aldo_ket_red
# DOMAIN	KCAB3_HUMAN	Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit. {ECO 0000305}. 
# Ensembl	ENST00000303790	ENSP00000302719; ENSG00000170049
# ExpressionAtlas	O43448	baseline and differential
# FUNCTION	KCAB3_HUMAN	Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5. {ECO 0000269|PubMed 9857044}. 
# GO_component	GO:0005737	cytoplasm; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:InterPro.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IEA:InterPro.
# GO_function	GO:0015459	potassium channel regulator activity; TAS:ProtInc.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Gene3D	3.20.20.100	-; 1.
# Genevisible	O43448	HS
# HGNC	HGNC:6230	KCNAB3
# InterPro	IPR001395	Aldo/ket_red/Kv-b
# InterPro	IPR005399	K_chnl_volt-dep_bsu_KCNAB-rel
# InterPro	IPR005402	K_chnl_volt-dep_bsu_KCNAB3
# InterPro	IPR005983	K_chnl_volt-dep_bsu_KCNAB
# InterPro	IPR023210	NADP_OxRdtase_dom
# KEGG_Brite	ko04040	Ion channels
# MIM	604111	gene
# Organism	KCAB3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11732	PTHR11732
# PRINTS	PR01577	KCNABCHANNEL
# PRINTS	PR01580	KCNAB3CHANEL
# Pfam	PF00248	Aldo_ket_red
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# RecName	KCAB3_HUMAN	Voltage-gated potassium channel subunit beta-3
# RefSeq	NP_004723	NM_004732.3
# SIMILARITY	Belongs to the shaker potassium channel beta subunit family. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCAB3_HUMAN	Cytoplasm {ECO 0000305}. 
# SUBUNIT	KCAB3_HUMAN	Forms heteromultimeric complex with alpha subunits. 
# SUPFAM	SSF51430	SSF51430
# TIGRFAMs	TIGR01293	Kv_beta
# TISSUE SPECIFICITY	Brain specific. Most prominent expression in cerebellum. Weaker signals detected in cortex, occipital lobe, frontal lobe and temporal lobe. Not detected in spinal cord, heart, lung, liver, kidney, pancreas, placenta and skeletal muscle. {ECO:0000269|PubMed	9857044}. 
# UCSC	uc002gjm	human
# eggNOG	COG0667	LUCA
# eggNOG	KOG1575	Eukaryota
BLAST	swissprot:KCAB3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCAB3_HUMAN
BioCyc	ZFISH:ENSG00000170049-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000170049-MONOMER
COXPRESdb	9196	http://coxpresdb.jp/data/gene/9196.shtml
CleanEx	HS_KCNAB3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNAB3
DOI	10.1074/jbc.273.52.35095	http://dx.doi.org/10.1074/jbc.273.52.35095
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF016411	http://www.ebi.ac.uk/ena/data/view/AF016411
EMBL	BC096232	http://www.ebi.ac.uk/ena/data/view/BC096232
EMBL	BC096234	http://www.ebi.ac.uk/ena/data/view/BC096234
EMBL	BC099634	http://www.ebi.ac.uk/ena/data/view/BC099634
Ensembl	ENST00000303790	http://www.ensembl.org/id/ENST00000303790
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0015459	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015459
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
Gene3D	3.20.20.100	http://www.cathdb.info/version/latest/superfamily/3.20.20.100
GeneCards	KCNAB3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNAB3
GeneID	9196	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9196
GeneTree	ENSGT00550000074567	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074567
H-InvDB	HIX0173736	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0173736
HGNC	HGNC:6230	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6230
HOGENOM	HOG000250283	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000250283&db=HOGENOM6
HOVERGEN	HBG052216	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052216&db=HOVERGEN
InParanoid	O43448	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O43448
IntAct	O43448	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O43448*
InterPro	IPR001395	http://www.ebi.ac.uk/interpro/entry/IPR001395
InterPro	IPR005399	http://www.ebi.ac.uk/interpro/entry/IPR005399
InterPro	IPR005402	http://www.ebi.ac.uk/interpro/entry/IPR005402
InterPro	IPR005983	http://www.ebi.ac.uk/interpro/entry/IPR005983
InterPro	IPR023210	http://www.ebi.ac.uk/interpro/entry/IPR023210
Jabion	9196	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9196
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:9196	http://www.genome.jp/dbget-bin/www_bget?hsa:9196
KEGG_Orthology	KO:K04884	http://www.genome.jp/dbget-bin/www_bget?KO:K04884
MIM	604111	http://www.ncbi.nlm.nih.gov/omim/604111
OMA	WHSFGHV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WHSFGHV
OrthoDB	EOG091G0KDN	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0KDN
PANTHER	PTHR11732	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11732
PRINTS	PR01577	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01577
PRINTS	PR01580	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01580
PSORT	swissprot:KCAB3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCAB3_HUMAN
PSORT-B	swissprot:KCAB3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCAB3_HUMAN
PSORT2	swissprot:KCAB3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCAB3_HUMAN
Pfam	PF00248	http://pfam.xfam.org/family/PF00248
PharmGKB	PA30024	http://www.pharmgkb.org/do/serve?objId=PA30024&objCls=Gene
Phobius	swissprot:KCAB3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCAB3_HUMAN
PhylomeDB	O43448	http://phylomedb.org/?seqid=O43448
ProteinModelPortal	O43448	http://www.proteinmodelportal.org/query/uniprot/O43448
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	9857044	http://www.ncbi.nlm.nih.gov/pubmed/9857044
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
RefSeq	NP_004723	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004723
SMR	O43448	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O43448
STRING	9606.ENSP00000302719	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000302719&targetmode=cogs
SUPFAM	SSF51430	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51430
TIGRFAMs	TIGR01293	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01293
UCSC	uc002gjm	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002gjm&org=rat
UniGene	Hs.435074	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.435074
UniProtKB	KCAB3_HUMAN	http://www.uniprot.org/uniprot/KCAB3_HUMAN
UniProtKB-AC	O43448	http://www.uniprot.org/uniprot/O43448
charge	swissprot:KCAB3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCAB3_HUMAN
eggNOG	COG0667	http://eggnogapi.embl.de/nog_data/html/tree/COG0667
eggNOG	KOG1575	http://eggnogapi.embl.de/nog_data/html/tree/KOG1575
epestfind	swissprot:KCAB3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCAB3_HUMAN
garnier	swissprot:KCAB3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCAB3_HUMAN
helixturnhelix	swissprot:KCAB3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCAB3_HUMAN
hmoment	swissprot:KCAB3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCAB3_HUMAN
iep	swissprot:KCAB3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCAB3_HUMAN
inforesidue	swissprot:KCAB3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCAB3_HUMAN
neXtProt	NX_O43448	http://www.nextprot.org/db/entry/NX_O43448
octanol	swissprot:KCAB3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCAB3_HUMAN
pepcoil	swissprot:KCAB3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCAB3_HUMAN
pepdigest	swissprot:KCAB3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCAB3_HUMAN
pepinfo	swissprot:KCAB3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCAB3_HUMAN
pepnet	swissprot:KCAB3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCAB3_HUMAN
pepstats	swissprot:KCAB3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCAB3_HUMAN
pepwheel	swissprot:KCAB3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCAB3_HUMAN
pepwindow	swissprot:KCAB3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCAB3_HUMAN
sigcleave	swissprot:KCAB3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCAB3_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNJ5_HUMAN	Cardiac inward rectifier
# AltName	KCNJ5_HUMAN	Heart KATP channel
# AltName	KCNJ5_HUMAN	Inward rectifier K(+) channel Kir3.4
# AltName	KCNJ5_HUMAN	KATP-1
# AltName	KCNJ5_HUMAN	Potassium channel, inwardly rectifying subfamily J member 5
# BioGrid	109964	16
# DISEASE	KCNJ5_HUMAN	Hyperaldosteronism, familial, 3 (HALD3) [MIM 613677]  A form of hyperaldosteronism characterized by hypertension secondary to massive adrenal mineralocorticoid production. HALD3 patients present with childhood hypertension, elevated aldosteronism levels, and high levels of the hybrid steroids 18-oxocortisol and 18-hydroxycortisol. Hypertension and aldosteronism are not reversed by administration of exogenous glucocorticoids and patients require adrenalectomy to control hypertension. {ECO 0000269|PubMed 21311022, ECO 0000269|PubMed 22203740, ECO 0000269|PubMed 22275527, ECO 0000269|PubMed 22308486, ECO 0000269|PubMed 22848660}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	KCNJ5_HUMAN	Long QT syndrome 13 (LQT13) [MIM 613485]  A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. {ECO 0000269|PubMed 20560207}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	KCNJ5_HUMAN	Note=Somatic mutations in KCNJ5 have been found in aldosterone-producing adrenal adenomas and can be responsible for aldosteronism associated with cell autonomous proliferation. APAs are typically solitary, well circumscribed tumors diagnosed between ages 30 and 70. They come to medical attention due to new or worsening hypertension, often with hypokalemia. The precise role of KCNJ5 mutations in APA is under debate. They produce increased sodium conductance and cell depolarization, which in adrenal glomerulosa cells produces calcium entry, the signal for aldosterone production and cell proliferation. However, they may not be causative of APA development but may be a consequence of tumorigenesis, playing only a contributory role toward aldosterone overproduction and tumor growth (PubMed 22275527). Somatic mutations in KCNJ5 have not been found in non-aldosterone secreting adrenal adenomas suggesting that they are specifically associated with APA (PubMed 22275527 and PubMed 22848660). {ECO 0000269|PubMed 21311022, ECO 0000269|PubMed 22203740, ECO 0000269|PubMed 22275527, ECO 0000269|PubMed 22848660}. 
# DrugBank	DB00898	Ethanol
# DrugBank	DB01016	Glyburide
# Ensembl	ENST00000338350	ENSP00000339960; ENSG00000120457
# Ensembl	ENST00000529694	ENSP00000433295; ENSG00000120457
# Ensembl	ENST00000533599	ENSP00000434266; ENSG00000120457
# FUNCTION	KCNJ5_HUMAN	This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008076	voltage-gated potassium channel complex; TAS:ProtInc.
# GO_component	GO:0009897	external side of plasma membrane; IEA:Ensembl.
# GO_component	GO:0030315	T-tubule; IEA:Ensembl.
# GO_function	GO:0015467	G-protein activated inward rectifier potassium channel activity; TAS:UniProtKB.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0010107	potassium ion import; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.40.1400	-; 1.
# Genevisible	P48544	HS
# HGNC	HGNC:6266	KCNJ5
# InterPro	IPR003277	K_chnl_inward-rec_Kir3.4
# InterPro	IPR013518	K_chnl_inward-rec_Kir_cyto
# InterPro	IPR014756	Ig_E-set
# InterPro	IPR016449	K_chnl_inward-rec_Kir
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00720	[Cardiovascular disease] Jervell and Lange-Nielsen syndrome (JLNS)
# KEGG_Disease	H01603	[Endocrine disease] Primary aldosteronism
# KEGG_Pathway	ko04713	Circadian entrainment
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04726	Serotonergic synapse
# KEGG_Pathway	ko04728	Dopaminergic synapse
# KEGG_Pathway	ko05032	Morphine addiction
# MIM	600734	gene
# MIM	613485	phenotype
# MIM	613677	phenotype
# Organism	KCNJ5_HUMAN	Homo sapiens (Human)
# Orphanet	101016	Romano-Ward syndrome
# Orphanet	251274	Familial hyperaldosteronism type III
# Orphanet	37553	Cardiodysrhythmic potassium-sensitive periodic paralysis
# Orphanet	85142	Aldosterone-producing adenoma
# PANTHER	PTHR11767	PTHR11767
# PIR	G02232	G02232
# PIRSF	PIRSF005465	GIRK_kir
# PRINTS	PR01320	KIRCHANNEL
# PRINTS	PR01330	KIR34CHANNEL
# Pfam	PF01007	IRK
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-1296041	Activation of G protein gated Potassium channels
# Reactome	R-HSA-997272	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
# RecName	KCNJ5_HUMAN	G protein-activated inward rectifier potassium channel 4
# RefSeq	NP_000881	NM_000890.3
# RefSeq	XP_011541111	XM_011542809.2
# RefSeq	XP_011541112	XM_011542810.2
# SIMILARITY	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCNJ5_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	May associate with GIRK1 and GIRK2 to form a G-protein- activated heteromultimer pore-forming unit. The resulting inward current is much larger (By similarity). {ECO	0000250}. 
# SUPFAM	SSF81296	SSF81296
# TCDB	1.A.2.1	inward rectifier k(+) channel (irk-c) family
# TISSUE SPECIFICITY	Islets, exocrine pancreas and heart. Expressed in the adrenal cortex, particularly the zona glomerulosa. {ECO:0000269|PubMed	21311022}. 
# UCSC	uc001qet	human
# eggNOG	ENOG410XQ62	LUCA
# eggNOG	KOG3827	Eukaryota
BLAST	swissprot:KCNJ5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNJ5_HUMAN
BioCyc	ZFISH:ENSG00000120457-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000120457-MONOMER
COXPRESdb	3762	http://coxpresdb.jp/data/gene/3762.shtml
CleanEx	HS_KCNJ5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNJ5
DOI	10.1016/S0898-6568(99)00059-5	http://dx.doi.org/10.1016/S0898-6568(99)00059-5
DOI	10.1016/j.ajhg.2010.04.017	http://dx.doi.org/10.1016/j.ajhg.2010.04.017
DOI	10.1038/370456a0	http://dx.doi.org/10.1038/370456a0
DOI	10.1038/378792a0	http://dx.doi.org/10.1038/378792a0
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.1121407109	http://dx.doi.org/10.1073/pnas.1121407109
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1198785	http://dx.doi.org/10.1126/science.1198785
DOI	10.1161/HYPERTENSIONAHA.111.183996	http://dx.doi.org/10.1161/HYPERTENSIONAHA.111.183996
DOI	10.1161/HYPERTENSIONAHA.111.186478	http://dx.doi.org/10.1161/HYPERTENSIONAHA.111.186478
DOI	10.1371/journal.pone.0041926	http://dx.doi.org/10.1371/journal.pone.0041926
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01016	http://www.drugbank.ca/drugs/DB01016
EMBL	AK312837	http://www.ebi.ac.uk/ena/data/view/AK312837
EMBL	AP000920	http://www.ebi.ac.uk/ena/data/view/AP000920
EMBL	BC069386	http://www.ebi.ac.uk/ena/data/view/BC069386
EMBL	BC069482	http://www.ebi.ac.uk/ena/data/view/BC069482
EMBL	BC069499	http://www.ebi.ac.uk/ena/data/view/BC069499
EMBL	BC069571	http://www.ebi.ac.uk/ena/data/view/BC069571
EMBL	BC074838	http://www.ebi.ac.uk/ena/data/view/BC074838
EMBL	BC074839	http://www.ebi.ac.uk/ena/data/view/BC074839
EMBL	D50134	http://www.ebi.ac.uk/ena/data/view/D50134
EMBL	L47208	http://www.ebi.ac.uk/ena/data/view/L47208
EMBL	U39195	http://www.ebi.ac.uk/ena/data/view/U39195
EMBL	U52154	http://www.ebi.ac.uk/ena/data/view/U52154
EMBL	X83582	http://www.ebi.ac.uk/ena/data/view/X83582
Ensembl	ENST00000338350	http://www.ensembl.org/id/ENST00000338350
Ensembl	ENST00000529694	http://www.ensembl.org/id/ENST00000529694
Ensembl	ENST00000533599	http://www.ensembl.org/id/ENST00000533599
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0009897	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009897
GO_component	GO:0030315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030315
GO_function	GO:0015467	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015467
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0010107	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010107
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.40.1400	http://www.cathdb.info/version/latest/superfamily/2.60.40.1400
GeneCards	KCNJ5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNJ5
GeneID	3762	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3762
GeneTree	ENSGT00760000118842	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118842
HGNC	HGNC:6266	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6266
HOGENOM	HOG000237325	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237325&db=HOGENOM6
HOVERGEN	HBG006178	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006178&db=HOVERGEN
HPA	CAB022569	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB022569
HPA	HPA014722	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014722
HPA	HPA017353	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA017353
InParanoid	P48544	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P48544
InterPro	IPR003277	http://www.ebi.ac.uk/interpro/entry/IPR003277
InterPro	IPR013518	http://www.ebi.ac.uk/interpro/entry/IPR013518
InterPro	IPR014756	http://www.ebi.ac.uk/interpro/entry/IPR014756
InterPro	IPR016449	http://www.ebi.ac.uk/interpro/entry/IPR016449
Jabion	3762	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3762
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00720	http://www.genome.jp/dbget-bin/www_bget?H00720
KEGG_Disease	H01603	http://www.genome.jp/dbget-bin/www_bget?H01603
KEGG_Gene	hsa:3762	http://www.genome.jp/dbget-bin/www_bget?hsa:3762
KEGG_Orthology	KO:K04999	http://www.genome.jp/dbget-bin/www_bget?KO:K04999
KEGG_Pathway	ko04713	http://www.genome.jp/kegg-bin/show_pathway?ko04713
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04726	http://www.genome.jp/kegg-bin/show_pathway?ko04726
KEGG_Pathway	ko04728	http://www.genome.jp/kegg-bin/show_pathway?ko04728
KEGG_Pathway	ko05032	http://www.genome.jp/kegg-bin/show_pathway?ko05032
MIM	600734	http://www.ncbi.nlm.nih.gov/omim/600734
MIM	613485	http://www.ncbi.nlm.nih.gov/omim/613485
MIM	613677	http://www.ncbi.nlm.nih.gov/omim/613677
MINT	MINT-90031	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-90031
OMA	MNQDMEI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MNQDMEI
Orphanet	101016	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=101016
Orphanet	251274	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=251274
Orphanet	37553	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=37553
Orphanet	85142	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=85142
OrthoDB	EOG091G08HC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08HC
PANTHER	PTHR11767	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11767
PRINTS	PR01320	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01320
PRINTS	PR01330	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01330
PSORT	swissprot:KCNJ5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNJ5_HUMAN
PSORT-B	swissprot:KCNJ5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNJ5_HUMAN
PSORT2	swissprot:KCNJ5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNJ5_HUMAN
Pfam	PF01007	http://pfam.xfam.org/family/PF01007
PharmGKB	PA216	http://www.pharmgkb.org/do/serve?objId=PA216&objCls=Gene
Phobius	swissprot:KCNJ5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNJ5_HUMAN
PhylomeDB	P48544	http://phylomedb.org/?seqid=P48544
ProteinModelPortal	P48544	http://www.proteinmodelportal.org/query/uniprot/P48544
PubMed	10659995	http://www.ncbi.nlm.nih.gov/pubmed/10659995
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	20560207	http://www.ncbi.nlm.nih.gov/pubmed/20560207
PubMed	21311022	http://www.ncbi.nlm.nih.gov/pubmed/21311022
PubMed	22203740	http://www.ncbi.nlm.nih.gov/pubmed/22203740
PubMed	22275527	http://www.ncbi.nlm.nih.gov/pubmed/22275527
PubMed	22308486	http://www.ncbi.nlm.nih.gov/pubmed/22308486
PubMed	22848660	http://www.ncbi.nlm.nih.gov/pubmed/22848660
PubMed	8047164	http://www.ncbi.nlm.nih.gov/pubmed/8047164
PubMed	8524415	http://www.ncbi.nlm.nih.gov/pubmed/8524415
PubMed	8558261	http://www.ncbi.nlm.nih.gov/pubmed/8558261
PubMed	8834003	http://www.ncbi.nlm.nih.gov/pubmed/8834003
Reactome	R-HSA-1296041	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296041
Reactome	R-HSA-997272	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-997272
RefSeq	NP_000881	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000881
RefSeq	XP_011541111	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011541111
RefSeq	XP_011541112	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011541112
SMR	P48544	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P48544
STRING	9606.ENSP00000339960	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000339960&targetmode=cogs
SUPFAM	SSF81296	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81296
TCDB	1.A.2.1	http://www.tcdb.org/search/result.php?tc=1.A.2.1
UCSC	uc001qet	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001qet&org=rat
UniGene	Hs.444595	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.444595
UniGene	Hs.632109	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.632109
UniProtKB	KCNJ5_HUMAN	http://www.uniprot.org/uniprot/KCNJ5_HUMAN
UniProtKB-AC	P48544	http://www.uniprot.org/uniprot/P48544
charge	swissprot:KCNJ5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNJ5_HUMAN
eggNOG	ENOG410XQ62	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ62
eggNOG	KOG3827	http://eggnogapi.embl.de/nog_data/html/tree/KOG3827
epestfind	swissprot:KCNJ5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNJ5_HUMAN
garnier	swissprot:KCNJ5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNJ5_HUMAN
helixturnhelix	swissprot:KCNJ5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNJ5_HUMAN
hmoment	swissprot:KCNJ5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNJ5_HUMAN
iep	swissprot:KCNJ5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNJ5_HUMAN
inforesidue	swissprot:KCNJ5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNJ5_HUMAN
neXtProt	NX_P48544	http://www.nextprot.org/db/entry/NX_P48544
octanol	swissprot:KCNJ5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNJ5_HUMAN
pepcoil	swissprot:KCNJ5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNJ5_HUMAN
pepdigest	swissprot:KCNJ5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNJ5_HUMAN
pepinfo	swissprot:KCNJ5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNJ5_HUMAN
pepnet	swissprot:KCNJ5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNJ5_HUMAN
pepstats	swissprot:KCNJ5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNJ5_HUMAN
pepwheel	swissprot:KCNJ5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNJ5_HUMAN
pepwindow	swissprot:KCNJ5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNJ5_HUMAN
sigcleave	swissprot:KCNJ5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNJ5_HUMAN
## Database	ID	URL or Descriptions
# AltName	CX6A1_HUMAN	Cytochrome c oxidase polypeptide VIa-liver
# AltName	CX6A1_HUMAN	Cytochrome c oxidase subunit VIA-liver
# BioGrid	107730	14
# CDD	cd00925	Cyt_c_Oxidase_VIa
# ChiTaRS	COX6A1	human
# DISEASE	CX6A1_HUMAN	Charcot-Marie-Tooth disease, recessive, intermediate type, D (CMTRID) [MIM 616039]  A form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Recessive intermediate forms of Charcot-Marie-Tooth disease are characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec. {ECO 0000269|PubMed 25152455}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000229379	ENSP00000229379; ENSG00000111775
# ExpressionAtlas	P12074	baseline and differential
# FUNCTION	CX6A1_HUMAN	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. 
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0005751	mitochondrial respiratory chain complex IV; IBA:GO_Central.
# GO_function	GO:0004129	cytochrome-c oxidase activity; IEA:InterPro.
# GO_function	GO:0030234	enzyme regulator activity; IBA:GO_Central.
# GO_process	GO:0006091	generation of precursor metabolites and energy; TAS:ProtInc.
# GO_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen; IBA:GO_Central.
# GO_process	GO:0009060	aerobic respiration; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0030234	enzyme regulator activity
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# Gene3D	4.10.95.10	-; 1.
# Genevisible	P12074	HS
# HGNC	HGNC:2277	COX6A1
# IntAct	P12074	4
# InterPro	IPR001349	Cyt_c_oxidase_su6a
# InterPro	IPR018507	Cyt_c_oxidase_su6a_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	602072	gene
# MIM	616039	phenotype
# Organism	CX6A1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11504	PTHR11504
# PIRSF	PIRSF000277	COX6A1
# PROSITE	PS01329	COX6A
# Pfam	PF02046	COX6A
# ProDom	PD006036	Cyt_c_oxidase_su6a
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-5628897	TP53 Regulates Metabolic Genes
# Reactome	R-HSA-611105	Respiratory electron transport
# RecName	CX6A1_HUMAN	Cytochrome c oxidase subunit 6A1, mitochondrial
# RefSeq	NP_004364	NM_004373.3
# SEQUENCE CAUTION	Sequence=CAA33392.1; Type=Frameshift; Positions=17; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the cytochrome c oxidase subunit 6A family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	CX6A1_HUMAN	Mitochondrion inner membrane. 
# SUPFAM	SSF81411	SSF81411
# UCSC	uc001tyf	human
# eggNOG	ENOG411253X	LUCA
# eggNOG	KOG3469	Eukaryota
BLAST	swissprot:CX6A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CX6A1_HUMAN
BioCyc	ZFISH:HS03462-MONOMER	http://biocyc.org/getid?id=ZFISH:HS03462-MONOMER
COXPRESdb	1337	http://coxpresdb.jp/data/gene/1337.shtml
CleanEx	HS_COX6A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_COX6A1
DOI	10.1002/elps.11501301201	http://dx.doi.org/10.1002/elps.11501301201
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.ajhg.2014.07.013	http://dx.doi.org/10.1016/j.ajhg.2014.07.013
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/nar/17.15.6409	http://dx.doi.org/10.1093/nar/17.15.6409
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AK312009	http://www.ebi.ac.uk/ena/data/view/AK312009
EMBL	AL021546	http://www.ebi.ac.uk/ena/data/view/AL021546
EMBL	BC007723	http://www.ebi.ac.uk/ena/data/view/BC007723
EMBL	BC070186	http://www.ebi.ac.uk/ena/data/view/BC070186
EMBL	BC107861	http://www.ebi.ac.uk/ena/data/view/BC107861
EMBL	X15341	http://www.ebi.ac.uk/ena/data/view/X15341
Ensembl	ENST00000229379	http://www.ensembl.org/id/ENST00000229379
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005751	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005751
GO_function	GO:0004129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004129
GO_function	GO:0030234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234
GO_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GO_process	GO:0006123	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006123
GO_process	GO:0009060	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009060
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0030234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
Gene3D	4.10.95.10	http://www.cathdb.info/version/latest/superfamily/4.10.95.10
GeneCards	COX6A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=COX6A1
GeneID	1337	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1337
GeneTree	ENSGT00390000002756	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002756
HGNC	HGNC:2277	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2277
HOGENOM	HOG000193965	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000193965&db=HOGENOM6
HOVERGEN	HBG060482	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG060482&db=HOVERGEN
HPA	HPA062394	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA062394
InParanoid	P12074	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P12074
IntAct	P12074	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P12074*
InterPro	IPR001349	http://www.ebi.ac.uk/interpro/entry/IPR001349
InterPro	IPR018507	http://www.ebi.ac.uk/interpro/entry/IPR018507
Jabion	1337	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1337
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Gene	hsa:1337	http://www.genome.jp/dbget-bin/www_bget?hsa:1337
KEGG_Orthology	KO:K02266	http://www.genome.jp/dbget-bin/www_bget?KO:K02266
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	602072	http://www.ncbi.nlm.nih.gov/omim/602072
MIM	616039	http://www.ncbi.nlm.nih.gov/omim/616039
OMA	GYEGHDE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GYEGHDE
OrthoDB	EOG091G0C5F	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0C5F
PANTHER	PTHR11504	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11504
PROSITE	PS01329	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01329
PSORT	swissprot:CX6A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CX6A1_HUMAN
PSORT-B	swissprot:CX6A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CX6A1_HUMAN
PSORT2	swissprot:CX6A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CX6A1_HUMAN
Pfam	PF02046	http://pfam.xfam.org/family/PF02046
PharmGKB	PA26794	http://www.pharmgkb.org/do/serve?objId=PA26794&objCls=Gene
Phobius	swissprot:CX6A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CX6A1_HUMAN
PhylomeDB	P12074	http://phylomedb.org/?seqid=P12074
ProteinModelPortal	P12074	http://www.proteinmodelportal.org/query/uniprot/P12074
PubMed	1286669	http://www.ncbi.nlm.nih.gov/pubmed/1286669
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	25152455	http://www.ncbi.nlm.nih.gov/pubmed/25152455
PubMed	2549515	http://www.ncbi.nlm.nih.gov/pubmed/2549515
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-5628897	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5628897
Reactome	R-HSA-611105	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-611105
RefSeq	NP_004364	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004364
SMR	P12074	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P12074
STRING	9606.ENSP00000229379	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000229379&targetmode=cogs
SUPFAM	SSF81411	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81411
SWISS-2DPAGE	P12074	http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P12074
UCSC	uc001tyf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001tyf&org=rat
UniGene	Hs.369624	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.369624
UniProtKB	CX6A1_HUMAN	http://www.uniprot.org/uniprot/CX6A1_HUMAN
UniProtKB-AC	P12074	http://www.uniprot.org/uniprot/P12074
charge	swissprot:CX6A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CX6A1_HUMAN
eggNOG	ENOG411253X	http://eggnogapi.embl.de/nog_data/html/tree/ENOG411253X
eggNOG	KOG3469	http://eggnogapi.embl.de/nog_data/html/tree/KOG3469
epestfind	swissprot:CX6A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CX6A1_HUMAN
garnier	swissprot:CX6A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CX6A1_HUMAN
helixturnhelix	swissprot:CX6A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CX6A1_HUMAN
hmoment	swissprot:CX6A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CX6A1_HUMAN
iep	swissprot:CX6A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CX6A1_HUMAN
inforesidue	swissprot:CX6A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CX6A1_HUMAN
neXtProt	NX_P12074	http://www.nextprot.org/db/entry/NX_P12074
octanol	swissprot:CX6A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CX6A1_HUMAN
pepcoil	swissprot:CX6A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CX6A1_HUMAN
pepdigest	swissprot:CX6A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CX6A1_HUMAN
pepinfo	swissprot:CX6A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CX6A1_HUMAN
pepnet	swissprot:CX6A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CX6A1_HUMAN
pepstats	swissprot:CX6A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CX6A1_HUMAN
pepwheel	swissprot:CX6A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CX6A1_HUMAN
pepwindow	swissprot:CX6A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CX6A1_HUMAN
sigcleave	swissprot:CX6A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CX6A1_HUMAN
## Database	ID	URL or Descriptions
# AltName	TXTP_HUMAN	Citrate transport protein
# AltName	TXTP_HUMAN	Solute carrier family 25 member 1
# AltName	TXTP_HUMAN	Tricarboxylate carrier protein
# BioGrid	112464	46
# ChiTaRS	SLC25A1	human
# DISEASE	TXTP_HUMAN	Combined D-2- and L-2-hydroxyglutaric aciduria (D2L2AD) [MIM 615182]  An autosomal recessive neurometabolic disorder characterized by neonatal-onset encephalopathy with severe muscular weakness, intractable seizures, respiratory distress, and lack of psychomotor development resulting in early death. Brain imaging shows abnormalities including enlarged ventricles, delayed myelination, and germinal layer cysts. {ECO 0000269|PubMed 23561848}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000215882	ENSP00000215882; ENSG00000100075
# ExpressionAtlas	P53007	baseline and differential
# FUNCTION	TXTP_HUMAN	Involved in citrate-H(+)/malate exchange. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. 
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0015137	citrate transmembrane transporter activity; TAS:UniProtKB.
# GO_function	GO:0015142	tricarboxylic acid transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0006094	gluconeogenesis; TAS:Reactome.
# GO_process	GO:0035338	long-chain fatty-acyl-CoA biosynthetic process; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0005975	carbohydrate metabolic process
# GOslim_process	GO:0006790	sulfur compound metabolic process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0051186	cofactor metabolic process
# Gene3D	1.50.40.10	-; 1.
# Genevisible	P53007	HS
# HGNC	HGNC:10979	SLC25A1
# IntAct	P53007	25
# InterPro	IPR002067	Mit_carrier
# InterPro	IPR018108	Mitochondrial_sb/sol_carrier
# InterPro	IPR023395	Mt_carrier_dom
# KEGG_Brite	ko02001	Solute carrier family
# MIM	190315	gene
# MIM	615182	phenotype
# Organism	TXTP_HUMAN	Homo sapiens (Human)
# Orphanet	356978	D,L-2-hydroxyglutaric aciduria
# Orphanet	98914	Presynaptic congenital myasthenic syndromes
# PIR	G01789	G01789
# PRINTS	PR00926	MITOCARRIER
# PROSITE	PS50920	SOLCAR; 3
# Pfam	PF00153	Mito_carr; 3
# Proteomes	UP000005640	Chromosome 22
# Reactome	R-HSA-70263	Gluconeogenesis
# Reactome	R-HSA-75105	Fatty Acyl-CoA Biosynthesis
# RecName	TXTP_HUMAN	Tricarboxylate transport protein, mitochondrial
# RefSeq	NP_005975	NM_005984.4
# SIMILARITY	Belongs to the mitochondrial carrier (TC 2.A.29) family. {ECO	0000305}. 
# SIMILARITY	Contains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule	PRU00282}.
# SUBCELLULAR LOCATION	TXTP_HUMAN	Mitochondrion inner membrane; Multi-pass membrane protein. 
# SUPFAM	SSF103506	SSF103506
# TCDB	2.A.29.7	the mitochondrial carrier (mc) family
# UCSC	uc002zoz	human
# eggNOG	ENOG410YAYP	LUCA
# eggNOG	KOG0756	Eukaryota
BLAST	swissprot:TXTP_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TXTP_HUMAN
BioCyc	ZFISH:ENSG00000100075-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000100075-MONOMER
COXPRESdb	6576	http://coxpresdb.jp/data/gene/6576.shtml
CleanEx	HS_SLC25A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC25A1
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/geno.1995.9982	http://dx.doi.org/10.1006/geno.1995.9982
DOI	10.1006/geno.1996.0191	http://dx.doi.org/10.1006/geno.1996.0191
DOI	10.1016/j.ajhg.2013.03.009	http://dx.doi.org/10.1016/j.ajhg.2013.03.009
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AK292313	http://www.ebi.ac.uk/ena/data/view/AK292313
EMBL	BC004980	http://www.ebi.ac.uk/ena/data/view/BC004980
EMBL	BC008061	http://www.ebi.ac.uk/ena/data/view/BC008061
EMBL	L75823	http://www.ebi.ac.uk/ena/data/view/L75823
EMBL	L76134	http://www.ebi.ac.uk/ena/data/view/L76134
EMBL	U25147	http://www.ebi.ac.uk/ena/data/view/U25147
Ensembl	ENST00000215882	http://www.ensembl.org/id/ENST00000215882
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0015137	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015137
GO_function	GO:0015142	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015142
GO_process	GO:0006094	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006094
GO_process	GO:0035338	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035338
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GOslim_process	GO:0006790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0051186	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186
Gene3D	1.50.40.10	http://www.cathdb.info/version/latest/superfamily/1.50.40.10
GeneCards	SLC25A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC25A1
GeneID	6576	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6576
GeneTree	ENSGT00550000074856	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074856
H-InvDB	HIX0040279	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0040279
HGNC	HGNC:10979	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10979
HOVERGEN	HBG103009	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG103009&db=HOVERGEN
HPA	HPA030183	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA030183
InParanoid	P53007	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P53007
IntAct	P53007	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P53007*
InterPro	IPR002067	http://www.ebi.ac.uk/interpro/entry/IPR002067
InterPro	IPR018108	http://www.ebi.ac.uk/interpro/entry/IPR018108
InterPro	IPR023395	http://www.ebi.ac.uk/interpro/entry/IPR023395
Jabion	6576	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6576
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6576	http://www.genome.jp/dbget-bin/www_bget?hsa:6576
KEGG_Orthology	KO:K15100	http://www.genome.jp/dbget-bin/www_bget?KO:K15100
MIM	190315	http://www.ncbi.nlm.nih.gov/omim/190315
MIM	615182	http://www.ncbi.nlm.nih.gov/omim/615182
MINT	MINT-1153318	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1153318
OMA	KPKYRGF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KPKYRGF
Orphanet	356978	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=356978
Orphanet	98914	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98914
OrthoDB	EOG091G0KE7	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0KE7
PRINTS	PR00926	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00926
PROSITE	PS50920	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50920
PSORT	swissprot:TXTP_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TXTP_HUMAN
PSORT-B	swissprot:TXTP_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TXTP_HUMAN
PSORT2	swissprot:TXTP_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TXTP_HUMAN
Pfam	PF00153	http://pfam.xfam.org/family/PF00153
PharmGKB	PA35855	http://www.pharmgkb.org/do/serve?objId=PA35855&objCls=Gene
Phobius	swissprot:TXTP_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TXTP_HUMAN
PhylomeDB	P53007	http://phylomedb.org/?seqid=P53007
ProteinModelPortal	P53007	http://www.proteinmodelportal.org/query/uniprot/P53007
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	23561848	http://www.ncbi.nlm.nih.gov/pubmed/23561848
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	8660975	http://www.ncbi.nlm.nih.gov/pubmed/8660975
PubMed	8666394	http://www.ncbi.nlm.nih.gov/pubmed/8666394
Reactome	R-HSA-70263	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-70263
Reactome	R-HSA-75105	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-75105
RefSeq	NP_005975	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005975
STRING	9606.ENSP00000215882	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000215882&targetmode=cogs
SUPFAM	SSF103506	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103506
TCDB	2.A.29.7	http://www.tcdb.org/search/result.php?tc=2.A.29.7
UCSC	uc002zoz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002zoz&org=rat
UniGene	Hs.111024	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.111024
UniProtKB	TXTP_HUMAN	http://www.uniprot.org/uniprot/TXTP_HUMAN
UniProtKB-AC	P53007	http://www.uniprot.org/uniprot/P53007
charge	swissprot:TXTP_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TXTP_HUMAN
eggNOG	ENOG410YAYP	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YAYP
eggNOG	KOG0756	http://eggnogapi.embl.de/nog_data/html/tree/KOG0756
epestfind	swissprot:TXTP_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TXTP_HUMAN
garnier	swissprot:TXTP_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TXTP_HUMAN
helixturnhelix	swissprot:TXTP_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TXTP_HUMAN
hmoment	swissprot:TXTP_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TXTP_HUMAN
iep	swissprot:TXTP_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TXTP_HUMAN
inforesidue	swissprot:TXTP_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TXTP_HUMAN
neXtProt	NX_P53007	http://www.nextprot.org/db/entry/NX_P53007
octanol	swissprot:TXTP_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TXTP_HUMAN
pepcoil	swissprot:TXTP_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TXTP_HUMAN
pepdigest	swissprot:TXTP_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TXTP_HUMAN
pepinfo	swissprot:TXTP_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TXTP_HUMAN
pepnet	swissprot:TXTP_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TXTP_HUMAN
pepstats	swissprot:TXTP_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TXTP_HUMAN
pepwheel	swissprot:TXTP_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TXTP_HUMAN
pepwindow	swissprot:TXTP_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TXTP_HUMAN
sigcleave	swissprot:TXTP_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TXTP_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CAC1G_HUMAN	Event=Alternative splicing; Named isoforms=35; Name=5; IsoId=O43497-1; Sequence=Displayed; Name=1; Synonyms=Variant 89; IsoId=O43497-2; Sequence=VSP_000940, VSP_000943, VSP_000946; Name=2; Synonyms=Variant 25; IsoId=O43497-3; Sequence=VSP_000940, VSP_000944, VSP_000946; Name=3; IsoId=O43497-4; Sequence=VSP_000940; Name=4; Synonyms=Variant 88; IsoId=O43497-5; Sequence=VSP_000940, VSP_000943, VSP_000946, VSP_000948; Name=6; Synonyms=Variant 217; IsoId=O43497-6; Sequence=VSP_000943, VSP_000946; Name=7; Synonyms=Variant 221; IsoId=O43497-7; Sequence=VSP_000943, VSP_000947; Name=8; Synonyms=Variant 93; IsoId=O43497-8; Sequence=VSP_000940, VSP_000943, VSP_000947; Name=9; Synonyms=Variant 57; IsoId=O43497-9; Sequence=VSP_000940, VSP_000946; Name=10; IsoId=O43497-10; Sequence=VSP_000940, VSP_000945; Name=11; Synonyms=Variant 185; IsoId=O43497-11; Sequence=VSP_000946; Name=12; Synonyms=Variant 189; IsoId=O43497-12; Sequence=VSP_000947; Name=13; Synonyms=Variant 153; IsoId=O43497-13; Sequence=VSP_000944, VSP_000946; Name=14; Synonyms=Variant 137; IsoId=O43497-15; Sequence=VSP_000944, VSP_047550, VSP_000946; Name=15; Synonyms=Variant 157; IsoId=O43497-16; Sequence=VSP_000944, VSP_000947; Name=16; Synonyms=Variant 169; IsoId=O43497-17; Sequence=VSP_047550, VSP_000946; Name=17; Synonyms=Variant 184; IsoId=O43497-18; Sequence=VSP_000946, VSP_000948; Name=18; Synonyms=Variant 216; IsoId=O43497-19; Sequence=VSP_000943, VSP_000946, VSP_000948; Name=19; Synonyms=Variant 223; IsoId=O43497-20; Sequence=VSP_000943; Name=20; Synonyms=Variant 249; IsoId=O43497-21; Sequence=VSP_047548, VSP_000946; Name=21; Synonyms=Variant 313; IsoId=O43497-22; Sequence=VSP_000940, VSP_047545, VSP_000946; Name=22; Synonyms=Variant 409; IsoId=O43497-23; Sequence=VSP_047545, VSP_000944, VSP_000946; Name=23; Synonyms=Variant 441; IsoId=O43497-24; Sequence=VSP_047545, VSP_000946; Name=24; Synonyms=Variant 477; IsoId=O43497-25; Sequence=VSP_047545, VSP_000943, VSP_000947; Name=25; Synonyms=Variant 473; IsoId=O43497-26; Sequence=VSP_047545, VSP_000943, VSP_000946; Name=26; Synonyms=Variant 17; IsoId=O43497-27; Sequence=VSP_000940, VSP_000944, VSP_047551, VSP_047553; Name=27; Synonyms=Variant 33; IsoId=O43497-28; Sequence=VSP_000940, VSP_047549, VSP_047552; Name=28; Synonyms=Variant 49; IsoId=O43497-29; Sequence=VSP_000940, VSP_047551, VSP_047553; Name=29; Synonyms=Variant 145; IsoId=O43497-30; Sequence=VSP_000944, VSP_047551, VSP_047553; Name=30; Synonyms=Variant 177; IsoId=O43497-31; Sequence=VSP_047551, VSP_047553; Name=31; Synonyms=Variant 209; IsoId=O43497-32; Sequence=VSP_000943, VSP_047551, VSP_047553; Name=32; IsoId=O43497-33; Sequence=VSP_000940, VSP_000943; Note=Gene prediction based on EST data.; Name=33; Synonyms=Variant 441-d81; IsoId=O43497-34; Sequence=VSP_047546, VSP_000946; Name=34; Synonyms=Variant 473-d75; IsoId=O43497-35; Sequence=VSP_047547, VSP_000943, VSP_000946; Name=35; Synonyms=Variant 473-d81; IsoId=O43497-36; Sequence=VSP_047546, VSP_000943, VSP_000946; 
# AltName	CAC1G_HUMAN	Cav3.1c
# AltName	CAC1G_HUMAN	NBR13
# AltName	CAC1G_HUMAN	Voltage-gated calcium channel subunit alpha Cav3.1
# BioGrid	114427	2
# CCDS	CCDS45730	-. [O43497-1]
# CCDS	CCDS45731	-. [O43497-12]
# CCDS	CCDS45732	-. [O43497-11]
# CCDS	CCDS45733	-. [O43497-13]
# CCDS	CCDS45734	-. [O43497-33]
# CCDS	CCDS45735	-. [O43497-2]
# CCDS	CCDS45736	-. [O43497-5]
# CCDS	CCDS45737	-. [O43497-10]
# CCDS	CCDS54142	-. [O43497-7]
# CCDS	CCDS54143	-. [O43497-6]
# CCDS	CCDS54144	-. [O43497-9]
# CCDS	CCDS54145	-. [O43497-3]
# CCDS	CCDS54146	-. [O43497-8]
# CCDS	CCDS58565	-. [O43497-17]
# CCDS	CCDS58566	-. [O43497-18]
# CCDS	CCDS58567	-. [O43497-15]
# CCDS	CCDS58568	-. [O43497-16]
# CCDS	CCDS58569	-. [O43497-21]
# CCDS	CCDS58570	-. [O43497-20]
# CCDS	CCDS58571	-. [O43497-19]
# CCDS	CCDS58572	-. [O43497-24]
# CCDS	CCDS58573	-. [O43497-23]
# CCDS	CCDS58574	-. [O43497-25]
# CCDS	CCDS58575	-. [O43497-26]
# CCDS	CCDS58576	-. [O43497-22]
# ChiTaRS	CACNA1G	human
# DEVELOPMENTAL STAGE	Isoform 4, isoform 7, isoform 18, isoform 19, isoform 24, isoform 25 and isoform 31 are adult-specific. Isoform 8, isoform 14, isoform 15, isoform 16, isoform 17, isoform 20, isoform 21, isoform 22, isoform 23, isoform 26, isoform 27, isoform 28, isoform 29 and isoform 30 are fetal-specific. Isoform 1, isoform 2, isoform 6, isoform 9, isoform 11, isoform 12 and isoform 13 are expressed in both fetus and adult. {ECO:0000269|PubMed	16671074}. 
# DISEASE	CAC1G_HUMAN	Spinocerebellar ataxia 42 (SCA42) [MIM 616795]  A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA42 is a slowly progressive, autosomal dominant form with variable severity. {ECO 0000269|PubMed 26456284, ECO 0000269|PubMed 26715324}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	CAC1G_HUMAN	Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position. 
# DOMAIN	CAC1G_HUMAN	The linker region between repeat III and IV probably plays a role in the inactivation of the channel. The C-terminal part may be implicated in the anchoring of the protein to the membrane by interfering with or restricting its lateral diffusion. 
# DrugBank	DB00347	Trimethadione
# DrugBank	DB00421	Spironolactone
# DrugBank	DB00568	Cinnarizine
# DrugBank	DB00593	Ethosuximide
# DrugBank	DB00661	Verapamil
# DrugBank	DB00909	Zonisamide
# DrugBank	DB04841	Flunarizine
# DrugBank	DB05246	Methsuximide
# Ensembl	ENST00000352832	ENSP00000339302; ENSG00000006283. [O43497-2]
# Ensembl	ENST00000354983	ENSP00000347078; ENSG00000006283. [O43497-33]
# Ensembl	ENST00000358244	ENSP00000350979; ENSG00000006283. [O43497-5]
# Ensembl	ENST00000359106	ENSP00000352011; ENSG00000006283. [O43497-1]
# Ensembl	ENST00000360761	ENSP00000353990; ENSG00000006283. [O43497-9]
# Ensembl	ENST00000429973	ENSP00000414388; ENSG00000006283. [O43497-13]
# Ensembl	ENST00000442258	ENSP00000409759; ENSG00000006283. [O43497-3]
# Ensembl	ENST00000502264	ENSP00000425522; ENSG00000006283. [O43497-10]
# Ensembl	ENST00000503436	ENSP00000427231; ENSG00000006283. [O43497-29]
# Ensembl	ENST00000503485	ENSP00000427238; ENSG00000006283. [O43497-24]
# Ensembl	ENST00000503607	ENSP00000426558; ENSG00000006283. [O43497-27]
# Ensembl	ENST00000504076	ENSP00000425153; ENSG00000006283. [O43497-32]
# Ensembl	ENST00000505165	ENSP00000422268; ENSG00000006283. [O43497-18]
# Ensembl	ENST00000506406	ENSP00000426313; ENSG00000006283. [O43497-31]
# Ensembl	ENST00000507336	ENSP00000420918; ENSG00000006283. [O43497-20]
# Ensembl	ENST00000507510	ENSP00000423112; ENSG00000006283. [O43497-12]
# Ensembl	ENST00000507609	ENSP00000423045; ENSG00000006283. [O43497-17]
# Ensembl	ENST00000507896	ENSP00000421518; ENSG00000006283. [O43497-19]
# Ensembl	ENST00000510115	ENSP00000427173; ENSG00000006283. [O43497-8]
# Ensembl	ENST00000510366	ENSP00000426814; ENSG00000006283. [O43497-23]
# Ensembl	ENST00000511765	ENSP00000427247; ENSG00000006283. [O43497-30]
# Ensembl	ENST00000511768	ENSP00000424664; ENSG00000006283. [O43497-28]
# Ensembl	ENST00000512389	ENSP00000426261; ENSG00000006283. [O43497-6]
# Ensembl	ENST00000513689	ENSP00000426172; ENSG00000006283. [O43497-25]
# Ensembl	ENST00000513964	ENSP00000425451; ENSG00000006283. [O43497-26]
# Ensembl	ENST00000514079	ENSP00000423317; ENSG00000006283. [O43497-21]
# Ensembl	ENST00000514181	ENSP00000425698; ENSG00000006283. [O43497-15]
# Ensembl	ENST00000514717	ENSP00000422407; ENSG00000006283. [O43497-22]
# Ensembl	ENST00000515165	ENSP00000426098; ENSG00000006283. [O43497-11]
# Ensembl	ENST00000515411	ENSP00000423155; ENSG00000006283. [O43497-16]
# Ensembl	ENST00000515765	ENSP00000426232; ENSG00000006283. [O43497-7]
# ExpressionAtlas	O43497	baseline and differential
# FUNCTION	CAC1G_HUMAN	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. {ECO 0000269|PubMed 10648811, ECO 0000269|PubMed 10692398, ECO 0000269|PubMed 26456284, ECO 0000269|PubMed 26715324}. 
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005891	voltage-gated calcium channel complex; ISS:BHF-UCL.
# GO_function	GO:0008332	low voltage-gated calcium channel activity; IDA:UniProtKB.
# GO_function	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential; ISS:BHF-UCL.
# GO_function	GO:0086059	voltage-gated calcium channel activity involved SA node cell action potential; ISS:BHF-UCL.
# GO_function	GO:0097110	scaffold protein binding; IPI:BHF-UCL.
# GO_process	GO:0042391	regulation of membrane potential; IDA:BHF-UCL.
# GO_process	GO:0045956	positive regulation of calcium ion-dependent exocytosis; IBA:GO_Central.
# GO_process	GO:0070509	calcium ion import; IDA:BHF-UCL.
# GO_process	GO:0070588	calcium ion transmembrane transport; IDA:UniProtKB.
# GO_process	GO:0086010	membrane depolarization during action potential; IBA:GO_Central.
# GO_process	GO:0086015	SA node cell action potential; ISS:BHF-UCL.
# GO_process	GO:0086016	AV node cell action potential; ISS:BHF-UCL.
# GO_process	GO:0086018	SA node cell to atrial cardiac muscle cell signalling; ISS:BHF-UCL.
# GO_process	GO:0086027	AV node cell to bundle of His cell signaling; ISS:BHF-UCL.
# GO_process	GO:0086045	membrane depolarization during AV node cell action potential; ISS:BHF-UCL.
# GO_process	GO:0086046	membrane depolarization during SA node cell action potential; ISS:BHF-UCL.
# GO_process	GO:0086091	regulation of heart rate by cardiac conduction; ISS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.350	-; 4.
# Genevisible	O43497	HS
# HGNC	HGNC:1394	CACNA1G
# IntAct	O43497	2
# InterPro	IPR002077	VDCCAlpha1
# InterPro	IPR005445	VDCC_T_a1
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR030154	VDCC_T_a1G
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04010	MAPK signaling pathway
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04713	Circadian entrainment
# KEGG_Pathway	ko04930	Type II diabetes mellitus
# MIM	604065	gene
# MIM	616795	phenotype
# Organism	CAC1G_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10037:SF137	PTHR10037:SF137; 8
# PRINTS	PR00167	CACHANNEL
# PRINTS	PR01629	TVDCCALPHA1
# PTM	CAC1G_HUMAN	In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II. 
# Pfam	PF00520	Ion_trans; 4
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-419037	NCAM1 interactions
# RecName	CAC1G_HUMAN	Voltage-dependent T-type calcium channel subunit alpha-1G
# RefSeq	NP_001243253	NM_001256324.1. [O43497-16]
# RefSeq	NP_001243254	NM_001256325.1. [O43497-21]
# RefSeq	NP_001243255	NM_001256326.1. [O43497-25]
# RefSeq	NP_001243256	NM_001256327.1. [O43497-17]
# RefSeq	NP_001243257	NM_001256328.1. [O43497-15]
# RefSeq	NP_001243258	NM_001256329.1. [O43497-24]
# RefSeq	NP_001243259	NM_001256330.1. [O43497-26]
# RefSeq	NP_001243260	NM_001256331.1. [O43497-23]
# RefSeq	NP_001243261	NM_001256332.1. [O43497-22]
# RefSeq	NP_001243262	NM_001256333.1. [O43497-18]
# RefSeq	NP_001243263	NM_001256334.1. [O43497-19]
# RefSeq	NP_001243288	NM_001256359.1. [O43497-34]
# RefSeq	NP_001243289	NM_001256360.1. [O43497-35]
# RefSeq	NP_001243290	NM_001256361.1. [O43497-36]
# RefSeq	NP_061496	NM_018896.4. [O43497-1]
# RefSeq	NP_938190	NM_198376.2. [O43497-5]
# RefSeq	NP_938191	NM_198377.2. [O43497-20]
# RefSeq	NP_938192	NM_198378.2. [O43497-6]
# RefSeq	NP_938193	NM_198379.2. [O43497-8]
# RefSeq	NP_938194	NM_198380.2. [O43497-7]
# RefSeq	NP_938196	NM_198382.2. [O43497-9]
# RefSeq	NP_938197	NM_198383.2. [O43497-10]
# RefSeq	NP_938198	NM_198384.2. [O43497-11]
# RefSeq	NP_938199	NM_198385.2. [O43497-12]
# RefSeq	NP_938200	NM_198386.2. [O43497-13]
# RefSeq	NP_938201	NM_198387.2. [O43497-2]
# RefSeq	NP_938202	NM_198388.2. [O43497-3]
# RefSeq	NP_938406	NM_198396.2. [O43497-33]
# SIMILARITY	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1G subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	CAC1G_HUMAN	Cell membrane {ECO 0000269|PubMed 26715324}; Multi-pass membrane protein {ECO 0000255}. Cytoplasm {ECO 0000269|PubMed 26715324}. 
# TISSUE SPECIFICITY	CAC1G_HUMAN	Highly expressed in brain, in particular in the amygdala, subthalamic nuclei, cerebellum and thalamus. Moderate expression in heart; low expression in placenta, kidney and lung. Also expressed in colon and bone marrow and in tumoral cells to a lesser extent. Highly expressed in fetal brain, but also in peripheral fetal tissues as heart, kidney and lung, suggesting a developmentally regulated expression. 
# UCSC	uc002irj	human. [O43497-1]
# eggNOG	ENOG410XNP6	LUCA
# eggNOG	KOG2302	Eukaryota
BLAST	swissprot:CAC1G_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CAC1G_HUMAN
BioCyc	ZFISH:ENSG00000006283-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000006283-MONOMER
COXPRESdb	8913	http://coxpresdb.jp/data/gene/8913.shtml
DOI	10.1002/prot.20877	http://dx.doi.org/10.1002/prot.20877
DOI	10.1016/S0014-5793(99)01756-1	http://dx.doi.org/10.1016/S0014-5793(99)01756-1
DOI	10.1016/S0304-3940(99)00716-8	http://dx.doi.org/10.1016/S0304-3940(99)00716-8
DOI	10.1016/j.ajhg.2015.09.007	http://dx.doi.org/10.1016/j.ajhg.2015.09.007
DOI	10.1038/36110	http://dx.doi.org/10.1038/36110
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1074/jbc.275.9.6090	http://dx.doi.org/10.1074/jbc.275.9.6090
DOI	10.1093/dnares/6.5.329	http://dx.doi.org/10.1093/dnares/6.5.329
DOI	10.1093/dnares/9.3.99	http://dx.doi.org/10.1093/dnares/9.3.99
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/s13041-015-0180-4	http://dx.doi.org/10.1186/s13041-015-0180-4
DrugBank	DB00347	http://www.drugbank.ca/drugs/DB00347
DrugBank	DB00421	http://www.drugbank.ca/drugs/DB00421
DrugBank	DB00568	http://www.drugbank.ca/drugs/DB00568
DrugBank	DB00593	http://www.drugbank.ca/drugs/DB00593
DrugBank	DB00661	http://www.drugbank.ca/drugs/DB00661
DrugBank	DB00909	http://www.drugbank.ca/drugs/DB00909
DrugBank	DB04841	http://www.drugbank.ca/drugs/DB04841
DrugBank	DB05246	http://www.drugbank.ca/drugs/DB05246
EMBL	AB032949	http://www.ebi.ac.uk/ena/data/view/AB032949
EMBL	AC004590	http://www.ebi.ac.uk/ena/data/view/AC004590
EMBL	AC021491	http://www.ebi.ac.uk/ena/data/view/AC021491
EMBL	AF029228	http://www.ebi.ac.uk/ena/data/view/AF029228
EMBL	AF029229	http://www.ebi.ac.uk/ena/data/view/AF029229
EMBL	AF124351	http://www.ebi.ac.uk/ena/data/view/AF124351
EMBL	AF126965	http://www.ebi.ac.uk/ena/data/view/AF126965
EMBL	AF126966	http://www.ebi.ac.uk/ena/data/view/AF126966
EMBL	AF134985	http://www.ebi.ac.uk/ena/data/view/AF134985
EMBL	AF134986	http://www.ebi.ac.uk/ena/data/view/AF134986
EMBL	AF190860	http://www.ebi.ac.uk/ena/data/view/AF190860
EMBL	AF227744	http://www.ebi.ac.uk/ena/data/view/AF227744
EMBL	AF227745	http://www.ebi.ac.uk/ena/data/view/AF227745
EMBL	AF227746	http://www.ebi.ac.uk/ena/data/view/AF227746
EMBL	AF227747	http://www.ebi.ac.uk/ena/data/view/AF227747
EMBL	AF227748	http://www.ebi.ac.uk/ena/data/view/AF227748
EMBL	AF227749	http://www.ebi.ac.uk/ena/data/view/AF227749
EMBL	AF227750	http://www.ebi.ac.uk/ena/data/view/AF227750
EMBL	AF227751	http://www.ebi.ac.uk/ena/data/view/AF227751
EMBL	BC110995	http://www.ebi.ac.uk/ena/data/view/BC110995
EMBL	DQ494449	http://www.ebi.ac.uk/ena/data/view/DQ494449
EMBL	DQ494450	http://www.ebi.ac.uk/ena/data/view/DQ494450
EMBL	DQ494451	http://www.ebi.ac.uk/ena/data/view/DQ494451
EMBL	DQ494452	http://www.ebi.ac.uk/ena/data/view/DQ494452
EMBL	DQ494453	http://www.ebi.ac.uk/ena/data/view/DQ494453
EMBL	DQ494454	http://www.ebi.ac.uk/ena/data/view/DQ494454
EMBL	DQ494455	http://www.ebi.ac.uk/ena/data/view/DQ494455
EMBL	DQ494456	http://www.ebi.ac.uk/ena/data/view/DQ494456
EMBL	DQ494457	http://www.ebi.ac.uk/ena/data/view/DQ494457
EMBL	DQ494458	http://www.ebi.ac.uk/ena/data/view/DQ494458
EMBL	DQ494459	http://www.ebi.ac.uk/ena/data/view/DQ494459
EMBL	DQ494460	http://www.ebi.ac.uk/ena/data/view/DQ494460
EMBL	DQ494461	http://www.ebi.ac.uk/ena/data/view/DQ494461
EMBL	DQ494462	http://www.ebi.ac.uk/ena/data/view/DQ494462
EMBL	DQ494463	http://www.ebi.ac.uk/ena/data/view/DQ494463
EMBL	DQ494464	http://www.ebi.ac.uk/ena/data/view/DQ494464
EMBL	DQ494465	http://www.ebi.ac.uk/ena/data/view/DQ494465
EMBL	DQ494466	http://www.ebi.ac.uk/ena/data/view/DQ494466
EMBL	DQ494467	http://www.ebi.ac.uk/ena/data/view/DQ494467
EMBL	DQ494468	http://www.ebi.ac.uk/ena/data/view/DQ494468
EMBL	DQ494469	http://www.ebi.ac.uk/ena/data/view/DQ494469
EMBL	DQ494470	http://www.ebi.ac.uk/ena/data/view/DQ494470
EMBL	DQ494471	http://www.ebi.ac.uk/ena/data/view/DQ494471
EMBL	DQ494472	http://www.ebi.ac.uk/ena/data/view/DQ494472
EMBL	DQ494473	http://www.ebi.ac.uk/ena/data/view/DQ494473
EMBL	DQ494474	http://www.ebi.ac.uk/ena/data/view/DQ494474
EMBL	DQ494475	http://www.ebi.ac.uk/ena/data/view/DQ494475
EMBL	DQ494476	http://www.ebi.ac.uk/ena/data/view/DQ494476
EMBL	DQ494477	http://www.ebi.ac.uk/ena/data/view/DQ494477
EMBL	DQ494478	http://www.ebi.ac.uk/ena/data/view/DQ494478
EMBL	DQ494479	http://www.ebi.ac.uk/ena/data/view/DQ494479
Ensembl	ENST00000352832	http://www.ensembl.org/id/ENST00000352832
Ensembl	ENST00000354983	http://www.ensembl.org/id/ENST00000354983
Ensembl	ENST00000358244	http://www.ensembl.org/id/ENST00000358244
Ensembl	ENST00000359106	http://www.ensembl.org/id/ENST00000359106
Ensembl	ENST00000360761	http://www.ensembl.org/id/ENST00000360761
Ensembl	ENST00000429973	http://www.ensembl.org/id/ENST00000429973
Ensembl	ENST00000442258	http://www.ensembl.org/id/ENST00000442258
Ensembl	ENST00000502264	http://www.ensembl.org/id/ENST00000502264
Ensembl	ENST00000503436	http://www.ensembl.org/id/ENST00000503436
Ensembl	ENST00000503485	http://www.ensembl.org/id/ENST00000503485
Ensembl	ENST00000503607	http://www.ensembl.org/id/ENST00000503607
Ensembl	ENST00000504076	http://www.ensembl.org/id/ENST00000504076
Ensembl	ENST00000505165	http://www.ensembl.org/id/ENST00000505165
Ensembl	ENST00000506406	http://www.ensembl.org/id/ENST00000506406
Ensembl	ENST00000507336	http://www.ensembl.org/id/ENST00000507336
Ensembl	ENST00000507510	http://www.ensembl.org/id/ENST00000507510
Ensembl	ENST00000507609	http://www.ensembl.org/id/ENST00000507609
Ensembl	ENST00000507896	http://www.ensembl.org/id/ENST00000507896
Ensembl	ENST00000510115	http://www.ensembl.org/id/ENST00000510115
Ensembl	ENST00000510366	http://www.ensembl.org/id/ENST00000510366
Ensembl	ENST00000511765	http://www.ensembl.org/id/ENST00000511765
Ensembl	ENST00000511768	http://www.ensembl.org/id/ENST00000511768
Ensembl	ENST00000512389	http://www.ensembl.org/id/ENST00000512389
Ensembl	ENST00000513689	http://www.ensembl.org/id/ENST00000513689
Ensembl	ENST00000513964	http://www.ensembl.org/id/ENST00000513964
Ensembl	ENST00000514079	http://www.ensembl.org/id/ENST00000514079
Ensembl	ENST00000514181	http://www.ensembl.org/id/ENST00000514181
Ensembl	ENST00000514717	http://www.ensembl.org/id/ENST00000514717
Ensembl	ENST00000515165	http://www.ensembl.org/id/ENST00000515165
Ensembl	ENST00000515411	http://www.ensembl.org/id/ENST00000515411
Ensembl	ENST00000515765	http://www.ensembl.org/id/ENST00000515765
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005891
GO_function	GO:0008332	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008332
GO_function	GO:0086056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086056
GO_function	GO:0086059	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086059
GO_function	GO:0097110	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097110
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0045956	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045956
GO_process	GO:0070509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070509
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:0086010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086010
GO_process	GO:0086015	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086015
GO_process	GO:0086016	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086016
GO_process	GO:0086018	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086018
GO_process	GO:0086027	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086027
GO_process	GO:0086045	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086045
GO_process	GO:0086046	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086046
GO_process	GO:0086091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086091
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	CACNA1G	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CACNA1G
GeneID	8913	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8913
GeneTree	ENSGT00830000128242	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00830000128242
HGNC	HGNC:1394	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1394
HOGENOM	HOG000007742	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007742&db=HOGENOM6
HOVERGEN	HBG050764	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050764&db=HOVERGEN
HPA	HPA004714	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA004714
InParanoid	O43497	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O43497
IntAct	O43497	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O43497*
InterPro	IPR002077	http://www.ebi.ac.uk/interpro/entry/IPR002077
InterPro	IPR005445	http://www.ebi.ac.uk/interpro/entry/IPR005445
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR030154	http://www.ebi.ac.uk/interpro/entry/IPR030154
Jabion	8913	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=8913
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:8913	http://www.genome.jp/dbget-bin/www_bget?hsa:8913
KEGG_Orthology	KO:K04854	http://www.genome.jp/dbget-bin/www_bget?KO:K04854
KEGG_Pathway	ko04010	http://www.genome.jp/kegg-bin/show_pathway?ko04010
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04713	http://www.genome.jp/kegg-bin/show_pathway?ko04713
KEGG_Pathway	ko04930	http://www.genome.jp/kegg-bin/show_pathway?ko04930
MIM	604065	http://www.ncbi.nlm.nih.gov/omim/604065
MIM	616795	http://www.ncbi.nlm.nih.gov/omim/616795
MINT	MINT-2796172	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-2796172
OMA	ALESNMQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ALESNMQ
OrthoDB	EOG091G02L1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02L1
PANTHER	PTHR10037:SF137	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10037:SF137
PRINTS	PR00167	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00167
PRINTS	PR01629	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01629
PSORT	swissprot:CAC1G_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CAC1G_HUMAN
PSORT-B	swissprot:CAC1G_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CAC1G_HUMAN
PSORT2	swissprot:CAC1G_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CAC1G_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
PharmGKB	PA381	http://www.pharmgkb.org/do/serve?objId=PA381&objCls=Gene
Phobius	swissprot:CAC1G_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CAC1G_HUMAN
PhylomeDB	O43497	http://phylomedb.org/?seqid=O43497
ProteinModelPortal	O43497	http://www.proteinmodelportal.org/query/uniprot/O43497
PubMed	10493502	http://www.ncbi.nlm.nih.gov/pubmed/10493502
PubMed	10548410	http://www.ncbi.nlm.nih.gov/pubmed/10548410
PubMed	10574461	http://www.ncbi.nlm.nih.gov/pubmed/10574461
PubMed	10648811	http://www.ncbi.nlm.nih.gov/pubmed/10648811
PubMed	10692398	http://www.ncbi.nlm.nih.gov/pubmed/10692398
PubMed	12168954	http://www.ncbi.nlm.nih.gov/pubmed/12168954
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	16671074	http://www.ncbi.nlm.nih.gov/pubmed/16671074
PubMed	26456284	http://www.ncbi.nlm.nih.gov/pubmed/26456284
PubMed	26715324	http://www.ncbi.nlm.nih.gov/pubmed/26715324
PubMed	9495342	http://www.ncbi.nlm.nih.gov/pubmed/9495342
Reactome	R-HSA-419037	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-419037
RefSeq	NP_001243253	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243253
RefSeq	NP_001243254	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243254
RefSeq	NP_001243255	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243255
RefSeq	NP_001243256	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243256
RefSeq	NP_001243257	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243257
RefSeq	NP_001243258	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243258
RefSeq	NP_001243259	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243259
RefSeq	NP_001243260	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243260
RefSeq	NP_001243261	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243261
RefSeq	NP_001243262	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243262
RefSeq	NP_001243263	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243263
RefSeq	NP_001243288	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243288
RefSeq	NP_001243289	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243289
RefSeq	NP_001243290	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243290
RefSeq	NP_061496	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061496
RefSeq	NP_938190	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_938190
RefSeq	NP_938191	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_938191
RefSeq	NP_938192	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_938192
RefSeq	NP_938193	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_938193
RefSeq	NP_938194	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_938194
RefSeq	NP_938196	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_938196
RefSeq	NP_938197	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_938197
RefSeq	NP_938198	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_938198
RefSeq	NP_938199	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_938199
RefSeq	NP_938200	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_938200
RefSeq	NP_938201	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_938201
RefSeq	NP_938202	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_938202
RefSeq	NP_938406	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_938406
STRING	9606.ENSP00000352011	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000352011&targetmode=cogs
UCSC	uc002irj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002irj&org=rat
UniGene	Hs.591169	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.591169
UniProtKB	CAC1G_HUMAN	http://www.uniprot.org/uniprot/CAC1G_HUMAN
UniProtKB-AC	O43497	http://www.uniprot.org/uniprot/O43497
charge	swissprot:CAC1G_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CAC1G_HUMAN
eggNOG	ENOG410XNP6	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNP6
eggNOG	KOG2302	http://eggnogapi.embl.de/nog_data/html/tree/KOG2302
epestfind	swissprot:CAC1G_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CAC1G_HUMAN
garnier	swissprot:CAC1G_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CAC1G_HUMAN
helixturnhelix	swissprot:CAC1G_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CAC1G_HUMAN
hmoment	swissprot:CAC1G_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CAC1G_HUMAN
iep	swissprot:CAC1G_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CAC1G_HUMAN
inforesidue	swissprot:CAC1G_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CAC1G_HUMAN
neXtProt	NX_O43497	http://www.nextprot.org/db/entry/NX_O43497
octanol	swissprot:CAC1G_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CAC1G_HUMAN
pepcoil	swissprot:CAC1G_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CAC1G_HUMAN
pepdigest	swissprot:CAC1G_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CAC1G_HUMAN
pepinfo	swissprot:CAC1G_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CAC1G_HUMAN
pepnet	swissprot:CAC1G_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CAC1G_HUMAN
pepstats	swissprot:CAC1G_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CAC1G_HUMAN
pepwheel	swissprot:CAC1G_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CAC1G_HUMAN
pepwindow	swissprot:CAC1G_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CAC1G_HUMAN
sigcleave	swissprot:CAC1G_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CAC1G_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCJ18_HUMAN	Inward rectifier K(+) channel Kir2.6
# AltName	KCJ18_HUMAN	Potassium channel, inwardly rectifying subfamily J member 18
# DISEASE	KCJ18_HUMAN	Thyrotoxic periodic paralysis 2 (TTPP2) [MIM 613239]  A sporadic muscular disorder characterized by episodic weakness and hypokalemia during a thyrotoxic state. It is clinically similar to hereditary hypokalemic periodic paralysis, except for the fact that hyperthyroidism is an absolute requirement for disease manifestation. The disease presents with recurrent episodes of acute muscular weakness of the four extremities that vary in severity from paresis to complete paralysis. Attacks are triggered by ingestion of a high carbohydrate load or strenuous physical activity followed by a period of rest. Thyrotoxic periodic paralysis can occur in association with any cause of hyperthyroidism, but is most commonly associated with Graves disease. {ECO 0000269|PubMed 20074522}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# Ensembl	ENST00000567955	ENSP00000457807; ENSG00000260458
# FUNCTION	KCJ18_HUMAN	Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. {ECO 0000269|PubMed 20074522}. 
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0005242	inward rectifier potassium channel activity; IDA:UniProtKB.
# GO_process	GO:0010107	potassium ion import; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.40.1400	-; 1.
# HGNC	HGNC:39080	KCNJ18
# INDUCTION	Up-regulated by triiodothyronine. {ECO:0000269|PubMed	20074522}. 
# InterPro	IPR003272	K_chnl_inward-rec_Kir2.2
# InterPro	IPR013518	K_chnl_inward-rec_Kir_cyto
# InterPro	IPR013673	K_chnl_inward-rec_Kir_N
# InterPro	IPR014756	Ig_E-set
# InterPro	IPR016449	K_chnl_inward-rec_Kir
# KEGG_Disease	H00747	[Musculoskeletal disease; Nervous system disease; Inherited metabolic disease] Thyrotoxic hypokalemic periodic paralysis (TPP)
# MIM	613236	gene
# MIM	613239	phenotype
# Organism	KCJ18_HUMAN	Homo sapiens (Human)
# Orphanet	79102	Thyrotoxic periodic paralysis
# PANTHER	PTHR11767	PTHR11767
# PANTHER	PTHR11767:SF14	PTHR11767:SF14
# PRINTS	PR01320	KIRCHANNEL
# PRINTS	PR01325	KIR22CHANNEL
# PTM	KCJ18_HUMAN	Probably phosphorylated by PKC; decreases single-channel open probability. {ECO 0000269|PubMed 20074522}. 
# Pfam	PF01007	IRK
# Pfam	PF08466	IRK_N
# Proteomes	UP000005640	Chromosome 17
# RecName	KCJ18_HUMAN	Inward rectifier potassium channel 18
# RefSeq	NP_001181887	NM_001194958.2
# SIMILARITY	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ12 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCJ18_HUMAN	Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF81296	SSF81296
# TISSUE SPECIFICITY	Specifically expressed in skeletal muscle. {ECO:0000269|PubMed	20074522}. 
# UCSC	uc032exz	human
# eggNOG	ENOG410XQ62	LUCA
# eggNOG	KOG3827	Eukaryota
BLAST	swissprot:KCJ18_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCJ18_HUMAN
COXPRESdb	100134444	http://coxpresdb.jp/data/gene/100134444.shtml
DOI	10.1016/j.cell.2009.12.024	http://dx.doi.org/10.1016/j.cell.2009.12.024
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
EMBL	AC233702	http://www.ebi.ac.uk/ena/data/view/AC233702
EMBL	FJ434338	http://www.ebi.ac.uk/ena/data/view/FJ434338
Ensembl	ENST00000567955	http://www.ensembl.org/id/ENST00000567955
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005242	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005242
GO_process	GO:0010107	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010107
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.40.1400	http://www.cathdb.info/version/latest/superfamily/2.60.40.1400
GeneCards	KCNJ18	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNJ18
GeneID	100134444	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100134444
GeneTree	ENSGT00760000118842	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118842
HGNC	HGNC:39080	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:39080
HOVERGEN	HBG006178	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006178&db=HOVERGEN
HPA	HPA027021	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA027021
InParanoid	B7U540	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=B7U540
InterPro	IPR003272	http://www.ebi.ac.uk/interpro/entry/IPR003272
InterPro	IPR013518	http://www.ebi.ac.uk/interpro/entry/IPR013518
InterPro	IPR013673	http://www.ebi.ac.uk/interpro/entry/IPR013673
InterPro	IPR014756	http://www.ebi.ac.uk/interpro/entry/IPR014756
InterPro	IPR016449	http://www.ebi.ac.uk/interpro/entry/IPR016449
Jabion	100134444	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=100134444
KEGG_Disease	H00747	http://www.genome.jp/dbget-bin/www_bget?H00747
KEGG_Gene	hsa:100134444	http://www.genome.jp/dbget-bin/www_bget?hsa:100134444
MIM	613236	http://www.ncbi.nlm.nih.gov/omim/613236
MIM	613239	http://www.ncbi.nlm.nih.gov/omim/613239
OMA	HQHEMSI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HQHEMSI
Orphanet	79102	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=79102
OrthoDB	EOG091G08HC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08HC
PANTHER	PTHR11767	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11767
PANTHER	PTHR11767:SF14	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11767:SF14
PRINTS	PR01320	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01320
PRINTS	PR01325	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01325
PSORT	swissprot:KCJ18_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCJ18_HUMAN
PSORT-B	swissprot:KCJ18_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCJ18_HUMAN
PSORT2	swissprot:KCJ18_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCJ18_HUMAN
Pfam	PF01007	http://pfam.xfam.org/family/PF01007
Pfam	PF08466	http://pfam.xfam.org/family/PF08466
Phobius	swissprot:KCJ18_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCJ18_HUMAN
PhylomeDB	B7U540	http://phylomedb.org/?seqid=B7U540
ProteinModelPortal	B7U540	http://www.proteinmodelportal.org/query/uniprot/B7U540
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	20074522	http://www.ncbi.nlm.nih.gov/pubmed/20074522
RefSeq	NP_001181887	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001181887
SMR	B7U540	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=B7U540
STRING	9606.ENSP00000328150	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000328150&targetmode=cogs
SUPFAM	SSF81296	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81296
UCSC	uc032exz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc032exz&org=rat
UniGene	Hs.200629	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.200629
UniProtKB	KCJ18_HUMAN	http://www.uniprot.org/uniprot/KCJ18_HUMAN
UniProtKB-AC	B7U540	http://www.uniprot.org/uniprot/B7U540
charge	swissprot:KCJ18_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCJ18_HUMAN
eggNOG	ENOG410XQ62	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ62
eggNOG	KOG3827	http://eggnogapi.embl.de/nog_data/html/tree/KOG3827
epestfind	swissprot:KCJ18_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCJ18_HUMAN
garnier	swissprot:KCJ18_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCJ18_HUMAN
helixturnhelix	swissprot:KCJ18_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCJ18_HUMAN
hmoment	swissprot:KCJ18_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCJ18_HUMAN
iep	swissprot:KCJ18_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCJ18_HUMAN
inforesidue	swissprot:KCJ18_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCJ18_HUMAN
neXtProt	NX_B7U540	http://www.nextprot.org/db/entry/NX_B7U540
octanol	swissprot:KCJ18_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCJ18_HUMAN
pepcoil	swissprot:KCJ18_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCJ18_HUMAN
pepdigest	swissprot:KCJ18_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCJ18_HUMAN
pepinfo	swissprot:KCJ18_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCJ18_HUMAN
pepnet	swissprot:KCJ18_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCJ18_HUMAN
pepstats	swissprot:KCJ18_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCJ18_HUMAN
pepwheel	swissprot:KCJ18_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCJ18_HUMAN
pepwindow	swissprot:KCJ18_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCJ18_HUMAN
sigcleave	swissprot:KCJ18_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCJ18_HUMAN
## Database	ID	URL or Descriptions
# AltName	MOT8_HUMAN	Monocarboxylate transporter 7
# AltName	MOT8_HUMAN	Solute carrier family 16 member 2
# AltName	MOT8_HUMAN	X-linked PEST-containing transporter
# BioGrid	112455	4
# CDD	cd06174	MFS
# ChiTaRS	SLC16A2	human
# DISEASE	MOT8_HUMAN	Monocarboxylate transporter 8 deficiency (MCT8 deficiency) [MIM 300523]  Consists of a severe form of X-linked psychomotor retardation combined with abnormal thyroid hormone (TH) levels. Thyroid hormone deficiency can be caused by defects of hormone synthesis and action, but it has also been linked to a defect in cellular hormone transport. Affected patients are males with abnormal relative concentrations of three circulating iodothyronines, as well as severe neurological abnormalities, including global developmental delay, central hypotonia, spastic quadriplegia, dystonic movements, rotary nystagmus, and impaired gaze and hearing. Heterozygous females had a milder thyroid phenotype and no neurological defects. {ECO 0000269|PubMed 14661163, ECO 0000269|PubMed 15488219, ECO 0000269|PubMed 15889350, ECO 0000269|PubMed 18636565, ECO 0000269|PubMed 23550058, ECO 0000269|PubMed 25527620, ECO 0000269|PubMed 26426690, ECO 0000269|Ref.8}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00119	Pyruvic acid
# DrugBank	DB00135	L-Tyrosine
# DrugBank	DB00149	L-Leucine
# DrugBank	DB00150	L-Tryptophan
# DrugBank	DB00451	Levothyroxine
# DrugBank	DB01583	Liotrix
# Ensembl	ENST00000587091	ENSP00000465734; ENSG00000147100
# ExpressionAtlas	P36021	baseline and differential
# FUNCTION	MOT8_HUMAN	Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr. {ECO 0000269|PubMed 23550058, ECO 0000269|PubMed 26426690}. 
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_function	GO:0005215	transporter activity; TAS:ProtInc.
# GO_function	GO:0008028	monocarboxylic acid transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_function	GO:0015349	thyroid hormone transmembrane transporter activity; IMP:UniProtKB.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0015718	monocarboxylic acid transport; TAS:ProtInc.
# GO_process	GO:0070327	thyroid hormone transport; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	P36021	HS
# HGNC	HGNC:10923	SLC16A2
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# InterPro	IPR030761	MCT8
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H00650	[Endocrine disease; Mental retardation] Monocarboxylate transporter 8 deficiency
# MIM	300095	gene
# MIM	300523	phenotype
# MISCELLANEOUS	Abnormal brain development associated with MCT8 deficiency may be the consequence of either decreased or increased intracellular T3 concentrations. {ECO:0000269|PubMed	18636565}. 
# Organism	MOT8_HUMAN	Homo sapiens (Human)
# Orphanet	59	Allan-Herndon-Dudley syndrome
# PANTHER	PTHR11360:SF123	PTHR11360:SF123
# PIR	I39295	I39295
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-879518	Transport of organic anions
# RecName	MOT8_HUMAN	Monocarboxylate transporter 8
# RefSeq	NP_006508	NM_006517.4
# SEQUENCE CAUTION	Sequence=AAB60374.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAB60375.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	MOT8_HUMAN	Cell membrane {ECO 0000269|PubMed 23550058, ECO 0000269|PubMed 25527620, ECO 0000269|PubMed 26426690}; Multi- pass membrane protein {ECO 0000269|PubMed 23550058, ECO 0000269|PubMed 25527620}. 
# SUBUNIT	MOT8_HUMAN	Homodimer. {ECO 0000269|PubMed 19797118, ECO 0000269|PubMed 25527620}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.13.10	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	Highly expressed in liver and heart. {ECO:0000269|PubMed	7981683}. 
# UCSC	uc031tjy	human
# eggNOG	ENOG410IMVZ	Eukaryota
# eggNOG	ENOG410Z4JM	LUCA
BLAST	swissprot:MOT8_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MOT8_HUMAN
BioCyc	ZFISH:ENSG00000147100-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000147100-MONOMER
COXPRESdb	6567	http://coxpresdb.jp/data/gene/6567.shtml
CleanEx	HS_SLC16A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC16A2
DOI	10.1002/humu.20808	http://dx.doi.org/10.1002/humu.20808
DOI	10.1016/S0140-6736(04)17226-7	http://dx.doi.org/10.1016/S0140-6736(04)17226-7
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1038/ejhg.2008.66	http://dx.doi.org/10.1038/ejhg.2008.66
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1074/mcp.M111.015131	http://dx.doi.org/10.1074/mcp.M111.015131
DOI	10.1086/380999	http://dx.doi.org/10.1086/380999
DOI	10.1086/431313	http://dx.doi.org/10.1086/431313
DOI	10.1093/hmg/3.7.1133	http://dx.doi.org/10.1093/hmg/3.7.1133
DOI	10.1210/en.2009-0699	http://dx.doi.org/10.1210/en.2009-0699
DOI	10.1210/en.2012-2225	http://dx.doi.org/10.1210/en.2012-2225
DOI	10.1210/me.2012-1356	http://dx.doi.org/10.1210/me.2012-1356
DOI	10.1371/journal.pone.0139343	http://dx.doi.org/10.1371/journal.pone.0139343
DOI	10.1530/JME-14-0272	http://dx.doi.org/10.1530/JME-14-0272
DrugBank	DB00119	http://www.drugbank.ca/drugs/DB00119
DrugBank	DB00135	http://www.drugbank.ca/drugs/DB00135
DrugBank	DB00149	http://www.drugbank.ca/drugs/DB00149
DrugBank	DB00150	http://www.drugbank.ca/drugs/DB00150
DrugBank	DB00451	http://www.drugbank.ca/drugs/DB00451
DrugBank	DB01583	http://www.drugbank.ca/drugs/DB01583
EMBL	AB085789	http://www.ebi.ac.uk/ena/data/view/AB085789
EMBL	AC004073	http://www.ebi.ac.uk/ena/data/view/AC004073
EMBL	AL157934	http://www.ebi.ac.uk/ena/data/view/AL157934
EMBL	U05315	http://www.ebi.ac.uk/ena/data/view/U05315
EMBL	U05316	http://www.ebi.ac.uk/ena/data/view/U05316
EMBL	U05317	http://www.ebi.ac.uk/ena/data/view/U05317
EMBL	U05318	http://www.ebi.ac.uk/ena/data/view/U05318
EMBL	U05319	http://www.ebi.ac.uk/ena/data/view/U05319
EMBL	U05320	http://www.ebi.ac.uk/ena/data/view/U05320
EMBL	U05321	http://www.ebi.ac.uk/ena/data/view/U05321
Ensembl	ENST00000587091	http://www.ensembl.org/id/ENST00000587091
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0008028	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008028
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_function	GO:0015349	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015349
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0015718	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015718
GO_process	GO:0070327	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070327
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC16A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC16A2
GeneID	6567	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6567
GeneTree	ENSGT00740000115479	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00740000115479
H-InvDB	HIX0056105	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0056105
HGNC	HGNC:10923	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10923
HOVERGEN	HBG006387	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006387&db=HOVERGEN
HPA	CAB021892	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB021892
InParanoid	P36021	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36021
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
InterPro	IPR030761	http://www.ebi.ac.uk/interpro/entry/IPR030761
Jabion	6567	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6567
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00650	http://www.genome.jp/dbget-bin/www_bget?H00650
KEGG_Gene	hsa:6567	http://www.genome.jp/dbget-bin/www_bget?hsa:6567
KEGG_Orthology	KO:K08231	http://www.genome.jp/dbget-bin/www_bget?KO:K08231
MIM	300095	http://www.ncbi.nlm.nih.gov/omim/300095
MIM	300523	http://www.ncbi.nlm.nih.gov/omim/300523
OMA	IKQTWVL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IKQTWVL
Orphanet	59	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=59
OrthoDB	EOG091G0449	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0449
PANTHER	PTHR11360:SF123	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11360:SF123
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:MOT8_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MOT8_HUMAN
PSORT-B	swissprot:MOT8_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MOT8_HUMAN
PSORT2	swissprot:MOT8_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MOT8_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA35814	http://www.pharmgkb.org/do/serve?objId=PA35814&objCls=Gene
Phobius	swissprot:MOT8_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MOT8_HUMAN
PhylomeDB	P36021	http://phylomedb.org/?seqid=P36021
ProteinModelPortal	P36021	http://www.proteinmodelportal.org/query/uniprot/P36021
PubMed	14661163	http://www.ncbi.nlm.nih.gov/pubmed/14661163
PubMed	15488219	http://www.ncbi.nlm.nih.gov/pubmed/15488219
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	15889350	http://www.ncbi.nlm.nih.gov/pubmed/15889350
PubMed	18398436	http://www.ncbi.nlm.nih.gov/pubmed/18398436
PubMed	18636565	http://www.ncbi.nlm.nih.gov/pubmed/18636565
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19797118	http://www.ncbi.nlm.nih.gov/pubmed/19797118
PubMed	22223895	http://www.ncbi.nlm.nih.gov/pubmed/22223895
PubMed	23550058	http://www.ncbi.nlm.nih.gov/pubmed/23550058
PubMed	23610131	http://www.ncbi.nlm.nih.gov/pubmed/23610131
PubMed	25527620	http://www.ncbi.nlm.nih.gov/pubmed/25527620
PubMed	26426690	http://www.ncbi.nlm.nih.gov/pubmed/26426690
PubMed	7981683	http://www.ncbi.nlm.nih.gov/pubmed/7981683
Reactome	R-HSA-879518	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-879518
RefSeq	NP_006508	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006508
STRING	9606.ENSP00000276033	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000276033&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.13.10	http://www.tcdb.org/search/result.php?tc=2.A.1.13.10
UCSC	uc031tjy	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc031tjy&org=rat
UniGene	Hs.75317	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.75317
UniProtKB	MOT8_HUMAN	http://www.uniprot.org/uniprot/MOT8_HUMAN
UniProtKB-AC	P36021	http://www.uniprot.org/uniprot/P36021
charge	swissprot:MOT8_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MOT8_HUMAN
eggNOG	ENOG410IMVZ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IMVZ
eggNOG	ENOG410Z4JM	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z4JM
epestfind	swissprot:MOT8_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MOT8_HUMAN
garnier	swissprot:MOT8_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MOT8_HUMAN
helixturnhelix	swissprot:MOT8_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MOT8_HUMAN
hmoment	swissprot:MOT8_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MOT8_HUMAN
iep	swissprot:MOT8_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MOT8_HUMAN
inforesidue	swissprot:MOT8_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MOT8_HUMAN
neXtProt	NX_P36021	http://www.nextprot.org/db/entry/NX_P36021
octanol	swissprot:MOT8_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MOT8_HUMAN
pepcoil	swissprot:MOT8_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MOT8_HUMAN
pepdigest	swissprot:MOT8_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MOT8_HUMAN
pepinfo	swissprot:MOT8_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MOT8_HUMAN
pepnet	swissprot:MOT8_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MOT8_HUMAN
pepstats	swissprot:MOT8_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MOT8_HUMAN
pepwheel	swissprot:MOT8_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MOT8_HUMAN
pepwindow	swissprot:MOT8_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MOT8_HUMAN
sigcleave	swissprot:MOT8_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MOT8_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNQ5_HUMAN	Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=Q9NR82-1; Sequence=Displayed; Name=2; IsoId=Q9NR82-2; Sequence=VSP_001014; Name=3; IsoId=Q9NR82-3; Sequence=VSP_001015; Name=4; IsoId=Q9NR82-4; Sequence=VSP_022318, VSP_022319; Note=No experimental confirmation available.; Name=5; IsoId=Q9NR82-5; Sequence=VSP_045487; Note=No experimental confirmation available.; Name=6; IsoId=Q9NR82-6; Sequence=VSP_056731; Note=No experimental confirmation available.; Name=7; IsoId=Q9NR82-7; Sequence=VSP_056730; Note=No experimental confirmation available.; 
# AltName	KCNQ5_HUMAN	KQT-like 5
# AltName	KCNQ5_HUMAN	Potassium channel subunit alpha KvLQT5
# AltName	KCNQ5_HUMAN	Voltage-gated potassium channel subunit Kv7.5
# BioGrid	121149	6
# CCDS	CCDS4976	-. [Q9NR82-1]
# CCDS	CCDS55034	-. [Q9NR82-6]
# CCDS	CCDS55035	-. [Q9NR82-5]
# CCDS	CCDS55037	-. [Q9NR82-2]
# ChiTaRS	KCNQ5	human
# DOMAIN	KCNQ5_HUMAN	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. {ECO 0000250}. 
# DrugBank	DB04953	Ezogabine
# Ensembl	ENST00000342056	ENSP00000345055; ENSG00000185760. [Q9NR82-6]
# Ensembl	ENST00000370392	ENSP00000359419; ENSG00000185760. [Q9NR82-4]
# Ensembl	ENST00000370398	ENSP00000359425; ENSG00000185760. [Q9NR82-1]
# Ensembl	ENST00000628967	ENSP00000486187; ENSG00000185760. [Q9NR82-5]
# Ensembl	ENST00000629977	ENSP00000485743; ENSG00000185760. [Q9NR82-2]
# ExpressionAtlas	Q9NR82	baseline and differential
# FUNCTION	KCNQ5_HUMAN	Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1) muscarinic receptors. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008076	voltage-gated potassium channel complex; TAS:ProtInc.
# GO_component	GO:0030118	clathrin coat; IDA:UniProtKB.
# GO_function	GO:0005242	inward rectifier potassium channel activity; TAS:ProtInc.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IDA:UniProtKB.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; IBA:GO_Central.
# GO_process	GO:0006461	protein complex assembly; NAS:ProtInc.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0007267	cell-cell signaling
# Genevisible	Q9NR82	HS
# HGNC	HGNC:6299	KCNQ5
# InterPro	IPR003937	K_chnl_volt-dep_KCNQ
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR013821	K_chnl_volt-dep_KCNQ_C
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04725	Cholinergic synapse
# MIM	607357	gene
# Organism	KCNQ5_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11537	PTHR11537; 3
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01459	KCNQCHANNEL
# Pfam	PF00520	Ion_trans
# Pfam	PF03520	KCNQ_channel
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# RecName	KCNQ5_HUMAN	Potassium voltage-gated channel subfamily KQT member 5
# RefSeq	NP_001153602	NM_001160130.1. [Q9NR82-2]
# RefSeq	NP_001153604	NM_001160132.1. [Q9NR82-3]
# RefSeq	NP_001153605	NM_001160133.1. [Q9NR82-6]
# RefSeq	NP_001153606	NM_001160134.1. [Q9NR82-5]
# RefSeq	NP_062816	NM_019842.3. [Q9NR82-1]
# SEQUENCE CAUTION	Sequence=BAG61495.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.5/KCNQ5 sub-subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	KCNQ5_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	KCNQ5_HUMAN	Heteromultimer with KCNQ3 (PubMed 11159685). Heterotetramer with KCNQ1; has a voltage-gated potassium channel activity (PubMed 24855057). {ECO 0000269|PubMed 11159685, ECO 0000269|PubMed 24855057}. 
# TISSUE SPECIFICITY	KCNQ5_HUMAN	Strongly expressed in brain and skeletal muscle. In brain, expressed in cerebral cortex, occipital pole, frontal lobe and temporal lobe. Lower levels in hippocampus and putamen. Low to undetectable levels in medulla, cerebellum and thalamus. 
# UCSC	uc003pgj	human. [Q9NR82-1]
# eggNOG	COG1226	LUCA
# eggNOG	KOG1419	Eukaryota
BLAST	swissprot:KCNQ5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNQ5_HUMAN
BioCyc	ZFISH:G66-31038-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31038-MONOMER
COXPRESdb	56479	http://coxpresdb.jp/data/gene/56479.shtml
CleanEx	HS_KCNQ5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNQ5
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.bjp.0703861	http://dx.doi.org/10.1038/sj.bjp.0703861
DOI	10.1074/jbc.M002378200	http://dx.doi.org/10.1074/jbc.M002378200
DOI	10.1074/jbc.M003245200	http://dx.doi.org/10.1074/jbc.M003245200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1161/ATVBAHA.114.303801	http://dx.doi.org/10.1161/ATVBAHA.114.303801
DrugBank	DB04953	http://www.drugbank.ca/drugs/DB04953
EMBL	AF202977	http://www.ebi.ac.uk/ena/data/view/AF202977
EMBL	AF249278	http://www.ebi.ac.uk/ena/data/view/AF249278
EMBL	AF263835	http://www.ebi.ac.uk/ena/data/view/AF263835
EMBL	AJ272506	http://www.ebi.ac.uk/ena/data/view/AJ272506
EMBL	AJ272507	http://www.ebi.ac.uk/ena/data/view/AJ272507
EMBL	AJ272508	http://www.ebi.ac.uk/ena/data/view/AJ272508
EMBL	AJ272509	http://www.ebi.ac.uk/ena/data/view/AJ272509
EMBL	AJ272510	http://www.ebi.ac.uk/ena/data/view/AJ272510
EMBL	AJ272511	http://www.ebi.ac.uk/ena/data/view/AJ272511
EMBL	AJ272512	http://www.ebi.ac.uk/ena/data/view/AJ272512
EMBL	AJ272513	http://www.ebi.ac.uk/ena/data/view/AJ272513
EMBL	AJ272514	http://www.ebi.ac.uk/ena/data/view/AJ272514
EMBL	AJ272515	http://www.ebi.ac.uk/ena/data/view/AJ272515
EMBL	AJ272516	http://www.ebi.ac.uk/ena/data/view/AJ272516
EMBL	AJ272517	http://www.ebi.ac.uk/ena/data/view/AJ272517
EMBL	AJ272518	http://www.ebi.ac.uk/ena/data/view/AJ272518
EMBL	AJ272519	http://www.ebi.ac.uk/ena/data/view/AJ272519
EMBL	AK299550	http://www.ebi.ac.uk/ena/data/view/AK299550
EMBL	AL049845	http://www.ebi.ac.uk/ena/data/view/AL049845
EMBL	AL360232	http://www.ebi.ac.uk/ena/data/view/AL360232
EMBL	AL360236	http://www.ebi.ac.uk/ena/data/view/AL360236
EMBL	AL365232	http://www.ebi.ac.uk/ena/data/view/AL365232
EMBL	AL445569	http://www.ebi.ac.uk/ena/data/view/AL445569
EMBL	AL513522	http://www.ebi.ac.uk/ena/data/view/AL513522
EMBL	AL671823	http://www.ebi.ac.uk/ena/data/view/AL671823
EMBL	BC050689	http://www.ebi.ac.uk/ena/data/view/BC050689
EMBL	BC117359	http://www.ebi.ac.uk/ena/data/view/BC117359
EMBL	BC143554	http://www.ebi.ac.uk/ena/data/view/BC143554
EMBL	FO393414	http://www.ebi.ac.uk/ena/data/view/FO393414
Ensembl	ENST00000342056	http://www.ensembl.org/id/ENST00000342056
Ensembl	ENST00000370392	http://www.ensembl.org/id/ENST00000370392
Ensembl	ENST00000370398	http://www.ensembl.org/id/ENST00000370398
Ensembl	ENST00000628967	http://www.ensembl.org/id/ENST00000628967
Ensembl	ENST00000629977	http://www.ensembl.org/id/ENST00000629977
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0030118	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030118
GO_function	GO:0005242	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005242
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GeneCards	KCNQ5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNQ5
GeneID	56479	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56479
GeneTree	ENSGT00550000074513	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074513
HGNC	HGNC:6299	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6299
HOGENOM	HOG000220839	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220839&db=HOGENOM6
HOVERGEN	HBG059014	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG059014&db=HOVERGEN
HPA	HPA016655	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA016655
InParanoid	Q9NR82	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NR82
InterPro	IPR003937	http://www.ebi.ac.uk/interpro/entry/IPR003937
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR013821	http://www.ebi.ac.uk/interpro/entry/IPR013821
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	56479	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=56479
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:56479	http://www.genome.jp/dbget-bin/www_bget?hsa:56479
KEGG_Orthology	KO:K04930	http://www.genome.jp/dbget-bin/www_bget?KO:K04930
KEGG_Pathway	ko04725	http://www.genome.jp/kegg-bin/show_pathway?ko04725
MIM	607357	http://www.ncbi.nlm.nih.gov/omim/607357
OMA	RMYTSRK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RMYTSRK
PANTHER	PTHR11537	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01459	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01459
PSORT	swissprot:KCNQ5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNQ5_HUMAN
PSORT-B	swissprot:KCNQ5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNQ5_HUMAN
PSORT2	swissprot:KCNQ5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNQ5_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF03520	http://pfam.xfam.org/family/PF03520
PharmGKB	PA30077	http://www.pharmgkb.org/do/serve?objId=PA30077&objCls=Gene
Phobius	swissprot:KCNQ5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNQ5_HUMAN
PhylomeDB	Q9NR82	http://phylomedb.org/?seqid=Q9NR82
ProteinModelPortal	Q9NR82	http://www.proteinmodelportal.org/query/uniprot/Q9NR82
PubMed	10787416	http://www.ncbi.nlm.nih.gov/pubmed/10787416
PubMed	10816588	http://www.ncbi.nlm.nih.gov/pubmed/10816588
PubMed	11159685	http://www.ncbi.nlm.nih.gov/pubmed/11159685
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24855057	http://www.ncbi.nlm.nih.gov/pubmed/24855057
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
RefSeq	NP_001153602	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001153602
RefSeq	NP_001153604	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001153604
RefSeq	NP_001153605	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001153605
RefSeq	NP_001153606	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001153606
RefSeq	NP_062816	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_062816
STRING	9606.ENSP00000345055	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000345055&targetmode=cogs
UCSC	uc003pgj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003pgj&org=rat
UniGene	Hs.445324	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.445324
UniProtKB	KCNQ5_HUMAN	http://www.uniprot.org/uniprot/KCNQ5_HUMAN
UniProtKB-AC	Q9NR82	http://www.uniprot.org/uniprot/Q9NR82
charge	swissprot:KCNQ5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNQ5_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG1419	http://eggnogapi.embl.de/nog_data/html/tree/KOG1419
epestfind	swissprot:KCNQ5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNQ5_HUMAN
garnier	swissprot:KCNQ5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNQ5_HUMAN
helixturnhelix	swissprot:KCNQ5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNQ5_HUMAN
hmoment	swissprot:KCNQ5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNQ5_HUMAN
iep	swissprot:KCNQ5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNQ5_HUMAN
inforesidue	swissprot:KCNQ5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNQ5_HUMAN
neXtProt	NX_Q9NR82	http://www.nextprot.org/db/entry/NX_Q9NR82
octanol	swissprot:KCNQ5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNQ5_HUMAN
pepcoil	swissprot:KCNQ5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNQ5_HUMAN
pepdigest	swissprot:KCNQ5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNQ5_HUMAN
pepinfo	swissprot:KCNQ5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNQ5_HUMAN
pepnet	swissprot:KCNQ5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNQ5_HUMAN
pepstats	swissprot:KCNQ5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNQ5_HUMAN
pepwheel	swissprot:KCNQ5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNQ5_HUMAN
pepwindow	swissprot:KCNQ5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNQ5_HUMAN
sigcleave	swissprot:KCNQ5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNQ5_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TPC_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9HC21-1; Sequence=Displayed; Name=2; IsoId=Q9HC21-2; Sequence=VSP_053908; 
# AltName	TPC_HUMAN	Mitochondrial uncoupling protein 1
# AltName	TPC_HUMAN	Solute carrier family 25 member 19
# BioGrid	121903	16
# CCDS	CCDS11720	-. [Q9HC21-1]
# DISEASE	TPC_HUMAN	Microcephaly, Amish type (MCPHA) [MIM 607196]  A disorder characterized by severe congenital microcephaly and severe 2- ketoglutaric aciduria leading to death within the first year. {ECO 0000269|PubMed 12185364}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	TPC_HUMAN	Thiamine metabolism dysfunction syndrome 4, bilateral striatal degeneration and progressive polyneuropathy type (THMD4) [MIM 613710]  A disease characterized by recurrent episodes of flaccid paralysis and encephalopathy associated with bilateral striatal necrosis and chronic progressive polyneuropathy. {ECO 0000269|PubMed 19798730}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000320362	ENSP00000319574; ENSG00000125454. [Q9HC21-1]
# Ensembl	ENST00000375261	ENSP00000364410; ENSG00000125454. [Q9HC21-2]
# Ensembl	ENST00000402418	ENSP00000385312; ENSG00000125454. [Q9HC21-1]
# Ensembl	ENST00000416858	ENSP00000397818; ENSG00000125454. [Q9HC21-1]
# Ensembl	ENST00000442286	ENSP00000402202; ENSG00000125454. [Q9HC21-1]
# Ensembl	ENST00000580994	ENSP00000463795; ENSG00000125454. [Q9HC21-1]
# ExpressionAtlas	Q9HC21	baseline and differential
# FUNCTION	TPC_HUMAN	Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria. {ECO 0000269|PubMed 18280798}. 
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0030233	deoxynucleotide transmembrane transporter activity; TAS:UniProtKB.
# GO_process	GO:0030302	deoxynucleotide transport; NAS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Gene3D	1.50.40.10	-; 1.
# Genevisible	Q9HC21	HS
# HGNC	HGNC:14409	SLC25A19
# IntAct	Q9HC21	16
# InterPro	IPR002067	Mit_carrier
# InterPro	IPR018108	Mitochondrial_sb/sol_carrier
# InterPro	IPR023395	Mt_carrier_dom
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H00990	[Developmental disorder] Microcephaly, Amish type
# MIM	606521	gene
# MIM	607196	phenotype
# MIM	613710	phenotype
# MISCELLANEOUS	The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity). {ECO	0000250}. 
# Organism	TPC_HUMAN	Homo sapiens (Human)
# Orphanet	217396	Progressive demyelinating neuropathy with bilateral striatal necrosis
# Orphanet	99742	Amish lethal microcephaly
# PRINTS	PR00926	MITOCARRIER
# PROSITE	PS50920	SOLCAR; 3
# Pfam	PF00153	Mito_carr; 3
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-196819	Vitamin B1 (thiamin) metabolism
# RecName	TPC_HUMAN	Mitochondrial thiamine pyrophosphate carrier
# RefSeq	NP_001119593	NM_001126121.1. [Q9HC21-1]
# RefSeq	NP_001119594	NM_001126122.1. [Q9HC21-1]
# RefSeq	NP_068380	NM_021734.4. [Q9HC21-1]
# RefSeq	XP_005257616	XM_005257559.3. [Q9HC21-1]
# RefSeq	XP_005257617	XM_005257560.2. [Q9HC21-1]
# RefSeq	XP_005257618	XM_005257561.3. [Q9HC21-1]
# RefSeq	XP_005257619	XM_005257562.2. [Q9HC21-1]
# RefSeq	XP_006722070	XM_006722007.2. [Q9HC21-1]
# RefSeq	XP_016880415	XM_017024926.1. [Q9HC21-1]
# SIMILARITY	Belongs to the mitochondrial carrier (TC 2.A.29) family. {ECO	0000305}. 
# SIMILARITY	Contains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule	PRU00282}.
# SUBCELLULAR LOCATION	TPC_HUMAN	Mitochondrion inner membrane; Multi-pass membrane protein. 
# SUPFAM	SSF103506	SSF103506
# TCDB	2.A.29.16	the mitochondrial carrier (mc) family
# TISSUE SPECIFICITY	Expressed in all tissues examined except for placenta. Highest levels in colon, kidney, lung, testis, spleen, and brain. {ECO:0000269|PubMed	11226231}. 
# UCSC	uc002jns	human. [Q9HC21-1]
# eggNOG	ENOG410ZRF1	LUCA
# eggNOG	KOG0752	Eukaryota
BLAST	swissprot:TPC_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TPC_HUMAN
BioCyc	ZFISH:ENSG00000125454-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000125454-MONOMER
COXPRESdb	60386	http://coxpresdb.jp/data/gene/60386.shtml
CleanEx	HS_SLC25A19	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC25A19
DOI	10.1002/ana.21752	http://dx.doi.org/10.1002/ana.21752
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.mito.2008.01.001	http://dx.doi.org/10.1016/j.mito.2008.01.001
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1038/ng948	http://dx.doi.org/10.1038/ng948
DOI	10.1073/pnas.031430998	http://dx.doi.org/10.1073/pnas.031430998
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AC022211	http://www.ebi.ac.uk/ena/data/view/AC022211
EMBL	AF182404	http://www.ebi.ac.uk/ena/data/view/AF182404
EMBL	AJ251857	http://www.ebi.ac.uk/ena/data/view/AJ251857
EMBL	AJ301616	http://www.ebi.ac.uk/ena/data/view/AJ301616
EMBL	AY346372	http://www.ebi.ac.uk/ena/data/view/AY346372
EMBL	BC001075	http://www.ebi.ac.uk/ena/data/view/BC001075
EMBL	BC005120	http://www.ebi.ac.uk/ena/data/view/BC005120
Ensembl	ENST00000320362	http://www.ensembl.org/id/ENST00000320362
Ensembl	ENST00000375261	http://www.ensembl.org/id/ENST00000375261
Ensembl	ENST00000402418	http://www.ensembl.org/id/ENST00000402418
Ensembl	ENST00000416858	http://www.ensembl.org/id/ENST00000416858
Ensembl	ENST00000442286	http://www.ensembl.org/id/ENST00000442286
Ensembl	ENST00000580994	http://www.ensembl.org/id/ENST00000580994
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0030233	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030233
GO_process	GO:0030302	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030302
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
Gene3D	1.50.40.10	http://www.cathdb.info/version/latest/superfamily/1.50.40.10
GeneCards	SLC25A19	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC25A19
GeneID	60386	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=60386
GeneTree	ENSGT00550000074902	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074902
HGNC	HGNC:14409	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14409
HOGENOM	HOG000165726	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000165726&db=HOGENOM6
HOVERGEN	HBG105731	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG105731&db=HOVERGEN
InParanoid	Q9HC21	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9HC21
IntAct	Q9HC21	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9HC21*
InterPro	IPR002067	http://www.ebi.ac.uk/interpro/entry/IPR002067
InterPro	IPR018108	http://www.ebi.ac.uk/interpro/entry/IPR018108
InterPro	IPR023395	http://www.ebi.ac.uk/interpro/entry/IPR023395
Jabion	60386	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=60386
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00990	http://www.genome.jp/dbget-bin/www_bget?H00990
KEGG_Gene	hsa:60386	http://www.genome.jp/dbget-bin/www_bget?hsa:60386
KEGG_Orthology	KO:K15108	http://www.genome.jp/dbget-bin/www_bget?KO:K15108
MIM	606521	http://www.ncbi.nlm.nih.gov/omim/606521
MIM	607196	http://www.ncbi.nlm.nih.gov/omim/607196
MIM	613710	http://www.ncbi.nlm.nih.gov/omim/613710
OMA	VQFVTFE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VQFVTFE
Orphanet	217396	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=217396
Orphanet	99742	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=99742
OrthoDB	EOG091G0FNV	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0FNV
PRINTS	PR00926	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00926
PROSITE	PS50920	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50920
PSORT	swissprot:TPC_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TPC_HUMAN
PSORT-B	swissprot:TPC_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TPC_HUMAN
PSORT2	swissprot:TPC_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TPC_HUMAN
Pfam	PF00153	http://pfam.xfam.org/family/PF00153
PharmGKB	PA37879	http://www.pharmgkb.org/do/serve?objId=PA37879&objCls=Gene
Phobius	swissprot:TPC_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TPC_HUMAN
PhylomeDB	Q9HC21	http://phylomedb.org/?seqid=Q9HC21
ProteinModelPortal	Q9HC21	http://www.proteinmodelportal.org/query/uniprot/Q9HC21
PubMed	11226231	http://www.ncbi.nlm.nih.gov/pubmed/11226231
PubMed	12185364	http://www.ncbi.nlm.nih.gov/pubmed/12185364
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	18280798	http://www.ncbi.nlm.nih.gov/pubmed/18280798
PubMed	19798730	http://www.ncbi.nlm.nih.gov/pubmed/19798730
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-196819	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-196819
RefSeq	NP_001119593	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001119593
RefSeq	NP_001119594	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001119594
RefSeq	NP_068380	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_068380
RefSeq	XP_005257616	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005257616
RefSeq	XP_005257617	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005257617
RefSeq	XP_005257618	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005257618
RefSeq	XP_005257619	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005257619
RefSeq	XP_006722070	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006722070
RefSeq	XP_016880415	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016880415
STRING	9606.ENSP00000319574	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000319574&targetmode=cogs
SUPFAM	SSF103506	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103506
TCDB	2.A.29.16	http://www.tcdb.org/search/result.php?tc=2.A.29.16
UCSC	uc002jns	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002jns&org=rat
UniGene	Hs.514470	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.514470
UniProtKB	TPC_HUMAN	http://www.uniprot.org/uniprot/TPC_HUMAN
UniProtKB-AC	Q9HC21	http://www.uniprot.org/uniprot/Q9HC21
charge	swissprot:TPC_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TPC_HUMAN
eggNOG	ENOG410ZRF1	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZRF1
eggNOG	KOG0752	http://eggnogapi.embl.de/nog_data/html/tree/KOG0752
epestfind	swissprot:TPC_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TPC_HUMAN
garnier	swissprot:TPC_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TPC_HUMAN
helixturnhelix	swissprot:TPC_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TPC_HUMAN
hmoment	swissprot:TPC_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TPC_HUMAN
iep	swissprot:TPC_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TPC_HUMAN
inforesidue	swissprot:TPC_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TPC_HUMAN
neXtProt	NX_Q9HC21	http://www.nextprot.org/db/entry/NX_Q9HC21
octanol	swissprot:TPC_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TPC_HUMAN
pepcoil	swissprot:TPC_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TPC_HUMAN
pepdigest	swissprot:TPC_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TPC_HUMAN
pepinfo	swissprot:TPC_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TPC_HUMAN
pepnet	swissprot:TPC_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TPC_HUMAN
pepstats	swissprot:TPC_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TPC_HUMAN
pepwheel	swissprot:TPC_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TPC_HUMAN
pepwindow	swissprot:TPC_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TPC_HUMAN
sigcleave	swissprot:TPC_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TPC_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	MRP4_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=O15439-1; Sequence=Displayed; Name=2; IsoId=O15439-2; Sequence=VSP_035426; Name=3; IsoId=O15439-3; Sequence=VSP_043283, VSP_043284; Note=No experimental confirmation available.; Name=4; IsoId=O15439-4; Sequence=VSP_057413, VSP_043283, VSP_043284; Note=No experimental confirmation available.; 
# AltName	MRP4_HUMAN	ATP-binding cassette sub-family C member 4
# AltName	MRP4_HUMAN	MRP/cMOAT-related ABC transporter
# AltName	MRP4_HUMAN	Multi-specific organic anion transporter B
# BioGrid	115551	17
# CCDS	CCDS45061	-. [O15439-3]
# CCDS	CCDS76643	-. [O15439-4]
# CCDS	CCDS9474	-. [O15439-1]
# ChiTaRS	ABCC4	human
# DrugBank	DB00143	Glutathione
# DrugBank	DB00158	Folic Acid
# DrugBank	DB00198	Oseltamivir
# DrugBank	DB00203	Sildenafil
# DrugBank	DB00286	Conjugated Estrogens
# DrugBank	DB00300	Tenofovir
# DrugBank	DB00328	Indomethacin
# DrugBank	DB00352	Tioguanine
# DrugBank	DB00398	Sorafenib
# DrugBank	DB00482	Celecoxib
# DrugBank	DB00495	Zidovudine
# DrugBank	DB00544	Fluorouracil
# DrugBank	DB00563	Methotrexate
# DrugBank	DB00586	Diclofenac
# DrugBank	DB00650	Leucovorin
# DrugBank	DB00661	Verapamil
# DrugBank	DB00709	Lamivudine
# DrugBank	DB00712	Flurbiprofen
# DrugBank	DB00718	Adefovir Dipivoxil
# DrugBank	DB00731	Nateglinide
# DrugBank	DB00770	Alprostadil
# DrugBank	DB00814	Meloxicam
# DrugBank	DB00917	Dinoprostone
# DrugBank	DB00975	Dipyridamole
# DrugBank	DB01009	Ketoprofen
# DrugBank	DB01032	Probenecid
# DrugBank	DB01033	Mercaptopurine
# DrugBank	DB01050	Ibuprofen
# DrugBank	DB01076	Atorvastatin
# DrugBank	DB01098	Rosuvastatin
# DrugBank	DB01138	Sulfinpyrazone
# DrugBank	DB01268	Sunitinib
# DrugBank	DB01327	Cefazolin
# DrugBank	DB01586	Ursodeoxycholic acid
# DrugBank	DB02659	Cholic Acid
# DrugBank	DB08884	Gadoxetate
# Ensembl	ENST00000376887	ENSP00000366084; ENSG00000125257. [O15439-1]
# Ensembl	ENST00000536256	ENSP00000442024; ENSG00000125257. [O15439-4]
# Ensembl	ENST00000629385	ENSP00000487081; ENSG00000125257. [O15439-3]
# FUNCTION	MRP4_HUMAN	May be an organic anion pump relevant to cellular detoxification. 
# GO_component	GO:0005886	plasma membrane; IDA:MGI.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0016323	basolateral plasma membrane; IDA:CACAO.
# GO_component	GO:0031088	platelet dense granule membrane; IDA:MGI.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism; TAS:Reactome.
# GO_function	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity; NAS:UniProtKB.
# GO_function	GO:0043225	ATPase-coupled anion transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0002576	platelet degranulation; TAS:Reactome.
# GO_process	GO:0010243	response to organonitrogen compound; IEA:Ensembl.
# GO_process	GO:0014070	response to organic cyclic compound; IEA:Ensembl.
# GO_process	GO:0032310	prostaglandin secretion; IDA:MGI.
# GO_process	GO:0042384	cilium assembly; IMP:MGI.
# GO_process	GO:0042493	response to drug; IEA:Ensembl.
# GO_process	GO:0048661	positive regulation of smooth muscle cell proliferation; IEA:Ensembl.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 2.
# Genevisible	O15439	HS
# HGNC	HGNC:55	ABCC4
# IntAct	O15439	5
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR011527	ABC1_TM_dom
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR027417	P-loop_NTPase
# InterPro	IPR030240	ABCC4
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko02010	ABC transporters
# KEGG_Pathway	ko04976	Bile secretion
# MIM	605250	gene
# Organism	MRP4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR24223:SF237	PTHR24223:SF237
# PROSITE	PS00211	ABC_TRANSPORTER_1; 2
# PROSITE	PS50893	ABC_TRANSPORTER_2; 2
# PROSITE	PS50929	ABC_TM1F; 2
# Pfam	PF00005	ABC_tran; 2
# Pfam	PF00664	ABC_membrane; 2
# Proteomes	UP000005640	Chromosome 13
# Reactome	R-HSA-114608	Platelet degranulation
# Reactome	R-HSA-382556	ABC-family proteins mediated transport
# RecName	MRP4_HUMAN	Multidrug resistance-associated protein 4
# RefSeq	NP_001098985	NM_001105515.2. [O15439-3]
# RefSeq	NP_001288758	NM_001301829.1. [O15439-2]
# RefSeq	NP_001288759	NM_001301830.1. [O15439-4]
# RefSeq	NP_005836	NM_005845.4. [O15439-1]
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 2 ABC transmembrane type-1 domains. {ECO:0000255|PROSITE-ProRule	PRU00441}. 
# SIMILARITY	Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA; 2
# SUBCELLULAR LOCATION	MRP4_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain). {ECO:0000269|PubMed	22411990}. 
# SUPFAM	SSF52540	SSF52540; 2
# SUPFAM	SSF90123	SSF90123; 2
# TCDB	3.A.1.208	the atp-binding cassette (abc) superfamily
# TISSUE SPECIFICITY	MRP4_HUMAN	Widely expressed, with particularly high levels in prostate, but is barely detectable in liver. 
# UCSC	uc001vmd	human. [O15439-1]
# UCSC	uc010tih	human
# WEB RESOURCE	MRP4_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=O15439";
# eggNOG	COG1132	LUCA
# eggNOG	KOG0054	Eukaryota
BLAST	swissprot:MRP4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MRP4_HUMAN
BioCyc	ZFISH:ENSG00000125257-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000125257-MONOMER
COXPRESdb	10257	http://coxpresdb.jp/data/gene/10257.shtml
CleanEx	HS_ABCC4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCC4
DOI	10.1002/humu.20694	http://dx.doi.org/10.1002/humu.20694
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.legalmed.2010.04.001	http://dx.doi.org/10.1016/j.legalmed.2010.04.001
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature02379	http://dx.doi.org/10.1038/nature02379
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/jbc.M111.337931	http://dx.doi.org/10.1074/jbc.M111.337931
DOI	10.1074/jbc.M203262200	http://dx.doi.org/10.1074/jbc.M203262200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DrugBank	DB00143	http://www.drugbank.ca/drugs/DB00143
DrugBank	DB00158	http://www.drugbank.ca/drugs/DB00158
DrugBank	DB00198	http://www.drugbank.ca/drugs/DB00198
DrugBank	DB00203	http://www.drugbank.ca/drugs/DB00203
DrugBank	DB00286	http://www.drugbank.ca/drugs/DB00286
DrugBank	DB00300	http://www.drugbank.ca/drugs/DB00300
DrugBank	DB00328	http://www.drugbank.ca/drugs/DB00328
DrugBank	DB00352	http://www.drugbank.ca/drugs/DB00352
DrugBank	DB00398	http://www.drugbank.ca/drugs/DB00398
DrugBank	DB00482	http://www.drugbank.ca/drugs/DB00482
DrugBank	DB00495	http://www.drugbank.ca/drugs/DB00495
DrugBank	DB00544	http://www.drugbank.ca/drugs/DB00544
DrugBank	DB00563	http://www.drugbank.ca/drugs/DB00563
DrugBank	DB00586	http://www.drugbank.ca/drugs/DB00586
DrugBank	DB00650	http://www.drugbank.ca/drugs/DB00650
DrugBank	DB00661	http://www.drugbank.ca/drugs/DB00661
DrugBank	DB00709	http://www.drugbank.ca/drugs/DB00709
DrugBank	DB00712	http://www.drugbank.ca/drugs/DB00712
DrugBank	DB00718	http://www.drugbank.ca/drugs/DB00718
DrugBank	DB00731	http://www.drugbank.ca/drugs/DB00731
DrugBank	DB00770	http://www.drugbank.ca/drugs/DB00770
DrugBank	DB00814	http://www.drugbank.ca/drugs/DB00814
DrugBank	DB00917	http://www.drugbank.ca/drugs/DB00917
DrugBank	DB00975	http://www.drugbank.ca/drugs/DB00975
DrugBank	DB01009	http://www.drugbank.ca/drugs/DB01009
DrugBank	DB01032	http://www.drugbank.ca/drugs/DB01032
DrugBank	DB01033	http://www.drugbank.ca/drugs/DB01033
DrugBank	DB01050	http://www.drugbank.ca/drugs/DB01050
DrugBank	DB01076	http://www.drugbank.ca/drugs/DB01076
DrugBank	DB01098	http://www.drugbank.ca/drugs/DB01098
DrugBank	DB01138	http://www.drugbank.ca/drugs/DB01138
DrugBank	DB01268	http://www.drugbank.ca/drugs/DB01268
DrugBank	DB01327	http://www.drugbank.ca/drugs/DB01327
DrugBank	DB01586	http://www.drugbank.ca/drugs/DB01586
DrugBank	DB02659	http://www.drugbank.ca/drugs/DB02659
DrugBank	DB08884	http://www.drugbank.ca/drugs/DB08884
EMBL	AF071202	http://www.ebi.ac.uk/ena/data/view/AF071202
EMBL	AF541977	http://www.ebi.ac.uk/ena/data/view/AF541977
EMBL	AK296247	http://www.ebi.ac.uk/ena/data/view/AK296247
EMBL	AL139381	http://www.ebi.ac.uk/ena/data/view/AL139381
EMBL	AL139381	http://www.ebi.ac.uk/ena/data/view/AL139381
EMBL	AL139381	http://www.ebi.ac.uk/ena/data/view/AL139381
EMBL	AL157818	http://www.ebi.ac.uk/ena/data/view/AL157818
EMBL	AL157818	http://www.ebi.ac.uk/ena/data/view/AL157818
EMBL	AL157818	http://www.ebi.ac.uk/ena/data/view/AL157818
EMBL	AL356257	http://www.ebi.ac.uk/ena/data/view/AL356257
EMBL	AL356257	http://www.ebi.ac.uk/ena/data/view/AL356257
EMBL	AL356257	http://www.ebi.ac.uk/ena/data/view/AL356257
EMBL	AL359750	http://www.ebi.ac.uk/ena/data/view/AL359750
EMBL	AY081219	http://www.ebi.ac.uk/ena/data/view/AY081219
EMBL	AY207008	http://www.ebi.ac.uk/ena/data/view/AY207008
EMBL	BC041560	http://www.ebi.ac.uk/ena/data/view/BC041560
EMBL	CH471085	http://www.ebi.ac.uk/ena/data/view/CH471085
EMBL	CH471085	http://www.ebi.ac.uk/ena/data/view/CH471085
EMBL	U83660	http://www.ebi.ac.uk/ena/data/view/U83660
Ensembl	ENST00000376887	http://www.ensembl.org/id/ENST00000376887
Ensembl	ENST00000536256	http://www.ensembl.org/id/ENST00000536256
Ensembl	ENST00000629385	http://www.ensembl.org/id/ENST00000629385
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0031088	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031088
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0015662	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015662
GO_function	GO:0016404	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016404
GO_function	GO:0043225	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043225
GO_process	GO:0002576	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002576
GO_process	GO:0010243	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010243
GO_process	GO:0014070	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014070
GO_process	GO:0032310	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032310
GO_process	GO:0042384	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042384
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0048661	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048661
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCC4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCC4
GeneID	10257	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10257
GeneTree	ENSGT00860000133687	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00860000133687
HGNC	HGNC:55	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:55
HOVERGEN	HBG108314	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108314&db=HOVERGEN
HPA	HPA002476	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA002476
InParanoid	O15439	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O15439
IntAct	O15439	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O15439*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR011527	http://www.ebi.ac.uk/interpro/entry/IPR011527
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
InterPro	IPR030240	http://www.ebi.ac.uk/interpro/entry/IPR030240
Jabion	10257	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10257
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:10257	http://www.genome.jp/dbget-bin/www_bget?hsa:10257
KEGG_Orthology	KO:K05673	http://www.genome.jp/dbget-bin/www_bget?KO:K05673
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
MIM	605250	http://www.ncbi.nlm.nih.gov/omim/605250
OMA	CAMFVII	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CAMFVII
OrthoDB	EOG091G00IN	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00IN
PANTHER	PTHR24223:SF237	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24223:SF237
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PROSITE	PS50929	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929
PSORT	swissprot:MRP4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MRP4_HUMAN
PSORT-B	swissprot:MRP4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MRP4_HUMAN
PSORT2	swissprot:MRP4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MRP4_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF00664	http://pfam.xfam.org/family/PF00664
PharmGKB	PA397	http://www.pharmgkb.org/do/serve?objId=PA397&objCls=Gene
Phobius	swissprot:MRP4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MRP4_HUMAN
PhylomeDB	O15439	http://phylomedb.org/?seqid=O15439
ProteinModelPortal	O15439	http://www.proteinmodelportal.org/query/uniprot/O15439
PubMed	12105214	http://www.ncbi.nlm.nih.gov/pubmed/12105214
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15057823	http://www.ncbi.nlm.nih.gov/pubmed/15057823
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	18300232	http://www.ncbi.nlm.nih.gov/pubmed/18300232
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	20547088	http://www.ncbi.nlm.nih.gov/pubmed/20547088
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22411990	http://www.ncbi.nlm.nih.gov/pubmed/22411990
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	9270026	http://www.ncbi.nlm.nih.gov/pubmed/9270026
PubMed	9661885	http://www.ncbi.nlm.nih.gov/pubmed/9661885
Reactome	R-HSA-114608	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-114608
Reactome	R-HSA-382556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-382556
RefSeq	NP_001098985	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001098985
RefSeq	NP_001288758	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001288758
RefSeq	NP_001288759	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001288759
RefSeq	NP_005836	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005836
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	O15439	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O15439
STRING	9606.ENSP00000366084	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000366084&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
SUPFAM	SSF90123	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123
TCDB	3.A.1.208	http://www.tcdb.org/search/result.php?tc=3.A.1.208
UCSC	uc001vmd	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001vmd&org=rat
UCSC	uc010tih	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010tih&org=rat
UniGene	Hs.508423	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.508423
UniProtKB	MRP4_HUMAN	http://www.uniprot.org/uniprot/MRP4_HUMAN
UniProtKB-AC	O15439	http://www.uniprot.org/uniprot/O15439
charge	swissprot:MRP4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MRP4_HUMAN
eggNOG	COG1132	http://eggnogapi.embl.de/nog_data/html/tree/COG1132
eggNOG	KOG0054	http://eggnogapi.embl.de/nog_data/html/tree/KOG0054
epestfind	swissprot:MRP4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MRP4_HUMAN
garnier	swissprot:MRP4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MRP4_HUMAN
helixturnhelix	swissprot:MRP4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MRP4_HUMAN
hmoment	swissprot:MRP4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MRP4_HUMAN
iep	swissprot:MRP4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MRP4_HUMAN
inforesidue	swissprot:MRP4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MRP4_HUMAN
neXtProt	NX_O15439	http://www.nextprot.org/db/entry/NX_O15439
octanol	swissprot:MRP4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MRP4_HUMAN
pepcoil	swissprot:MRP4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MRP4_HUMAN
pepdigest	swissprot:MRP4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MRP4_HUMAN
pepinfo	swissprot:MRP4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MRP4_HUMAN
pepnet	swissprot:MRP4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MRP4_HUMAN
pepstats	swissprot:MRP4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MRP4_HUMAN
pepwheel	swissprot:MRP4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MRP4_HUMAN
pepwindow	swissprot:MRP4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MRP4_HUMAN
sigcleave	swissprot:MRP4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MRP4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TI17B_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O60830-1; Sequence=Displayed; Name=2; IsoId=O60830-2; Sequence=VSP_047215; Note=No experimental confirmation available.; 
# BioGrid	115539	12
# CCDS	CCDS14308	-. [O60830-1]
# CCDS	CCDS55411	-. [O60830-2]
# ChiTaRS	TIMM17B	human
# Ensembl	ENST00000376582	ENSP00000365766; ENSG00000126768. [O60830-1]
# Ensembl	ENST00000396779	ENSP00000379999; ENSG00000126768. [O60830-2]
# Ensembl	ENST00000465150	ENSP00000477073; ENSG00000126768. [O60830-2]
# ExpressionAtlas	O60830	baseline and differential
# FUNCTION	TI17B_HUMAN	Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. 
# GO_component	GO:0005743	mitochondrial inner membrane; IDA:GO_Central.
# GO_component	GO:0005744	mitochondrial inner membrane presequence translocase complex; IDA:BHF-UCL.
# GO_component	GO:0031305	integral component of mitochondrial inner membrane; IDA:BHF-UCL.
# GO_function	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity; IEA:InterPro.
# GO_process	GO:0006626	protein targeting to mitochondrion; TAS:ProtInc.
# GO_process	GO:0030150	protein import into mitochondrial matrix; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006605	protein targeting
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	O60830	HS
# HGNC	HGNC:17310	TIMM17B
# IntAct	O60830	3
# InterPro	IPR003397	Tim17/Tim22/Tim23/PMP24
# InterPro	IPR005678	Tim17
# MIM	300249	gene
# Organism	TI17B_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10485	PTHR10485
# Pfam	PF02466	Tim17
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-1268020	Mitochondrial protein import
# RecName	TI17B_HUMAN	Mitochondrial import inner membrane translocase subunit Tim17-B
# RefSeq	NP_001161419	NM_001167947.2. [O60830-2]
# RefSeq	NP_005825	NM_005834.4. [O60830-1]
# SIMILARITY	Belongs to the Tim17/Tim22/Tim23 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	TI17B_HUMAN	Mitochondrion inner membrane; Multi-pass membrane protein. 
# SUBUNIT	Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50. The complex interacts with the TIMM44 component of the PAM complex and with DNAJC15. {ECO:0000269|PubMed	23263864}. 
# TIGRFAMs	TIGR00980	3a0801so1tim17
# TISSUE SPECIFICITY	TI17B_HUMAN	Expression is abundant in heart and skeletal muscle, intermediate in brain, and weak in pancreas, placenta, kidney and liver. 
# TopDownProteomics	O60830-1	-. [O60830-1]
# UCSC	uc004dla	human. [O60830-1]
BLAST	swissprot:TI17B_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TI17B_HUMAN
BioCyc	ZFISH:ENSG00000126768-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000126768-MONOMER
COXPRESdb	10245	http://coxpresdb.jp/data/gene/10245.shtml
CleanEx	HS_TIMM17B	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TIMM17B
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/jmbi.1999.2751	http://dx.doi.org/10.1006/jmbi.1999.2751
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/hmg/dds541	http://dx.doi.org/10.1093/hmg/dds541
DOI	10.1101/gr.140200	http://dx.doi.org/10.1101/gr.140200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF034790	http://www.ebi.ac.uk/ena/data/view/AF034790
EMBL	AF077039	http://www.ebi.ac.uk/ena/data/view/AF077039
EMBL	AF196971	http://www.ebi.ac.uk/ena/data/view/AF196971
EMBL	AF207550	http://www.ebi.ac.uk/ena/data/view/AF207550
EMBL	AJ005895	http://www.ebi.ac.uk/ena/data/view/AJ005895
EMBL	AK290207	http://www.ebi.ac.uk/ena/data/view/AK290207
EMBL	BC010142	http://www.ebi.ac.uk/ena/data/view/BC010142
EMBL	BC091473	http://www.ebi.ac.uk/ena/data/view/BC091473
EMBL	CH471224	http://www.ebi.ac.uk/ena/data/view/CH471224
Ensembl	ENST00000376582	http://www.ensembl.org/id/ENST00000376582
Ensembl	ENST00000396779	http://www.ensembl.org/id/ENST00000396779
Ensembl	ENST00000465150	http://www.ensembl.org/id/ENST00000465150
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005744	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005744
GO_component	GO:0031305	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031305
GO_function	GO:0015450	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015450
GO_process	GO:0006626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006626
GO_process	GO:0030150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030150
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	TIMM17B	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TIMM17B
GeneID	10245	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10245
GeneTree	ENSGT00390000017780	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000017780
HGNC	HGNC:17310	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17310
HOGENOM	HOG000183190	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000183190&db=HOGENOM6
HOVERGEN	HBG054233	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054233&db=HOVERGEN
HPA	HPA029093	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA029093
InParanoid	O60830	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O60830
IntAct	O60830	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O60830*
InterPro	IPR003397	http://www.ebi.ac.uk/interpro/entry/IPR003397
InterPro	IPR005678	http://www.ebi.ac.uk/interpro/entry/IPR005678
Jabion	10245	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10245
KEGG_Gene	hsa:10245	http://www.genome.jp/dbget-bin/www_bget?hsa:10245
MIM	300249	http://www.ncbi.nlm.nih.gov/omim/300249
OMA	FRNAPVC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FRNAPVC
OrthoDB	EOG091G0PGZ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0PGZ
PANTHER	PTHR10485	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10485
PSORT	swissprot:TI17B_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TI17B_HUMAN
PSORT-B	swissprot:TI17B_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TI17B_HUMAN
PSORT2	swissprot:TI17B_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TI17B_HUMAN
Pfam	PF02466	http://pfam.xfam.org/family/PF02466
PharmGKB	PA38226	http://www.pharmgkb.org/do/serve?objId=PA38226&objCls=Gene
Phobius	swissprot:TI17B_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TI17B_HUMAN
PhylomeDB	O60830	http://phylomedb.org/?seqid=O60830
ProteinModelPortal	O60830	http://www.proteinmodelportal.org/query/uniprot/O60830
PubMed	10339406	http://www.ncbi.nlm.nih.gov/pubmed/10339406
PubMed	11042152	http://www.ncbi.nlm.nih.gov/pubmed/11042152
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23263864	http://www.ncbi.nlm.nih.gov/pubmed/23263864
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-1268020	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1268020
RefSeq	NP_001161419	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001161419
RefSeq	NP_005825	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005825
SMR	O60830	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O60830
TIGRFAMs	TIGR00980	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00980
UCSC	uc004dla	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004dla&org=rat
UniGene	Hs.30570	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.30570
UniProtKB	TI17B_HUMAN	http://www.uniprot.org/uniprot/TI17B_HUMAN
UniProtKB-AC	O60830	http://www.uniprot.org/uniprot/O60830
charge	swissprot:TI17B_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TI17B_HUMAN
epestfind	swissprot:TI17B_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TI17B_HUMAN
garnier	swissprot:TI17B_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TI17B_HUMAN
helixturnhelix	swissprot:TI17B_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TI17B_HUMAN
hmoment	swissprot:TI17B_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TI17B_HUMAN
iep	swissprot:TI17B_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TI17B_HUMAN
inforesidue	swissprot:TI17B_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TI17B_HUMAN
neXtProt	NX_O60830	http://www.nextprot.org/db/entry/NX_O60830
octanol	swissprot:TI17B_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TI17B_HUMAN
pepcoil	swissprot:TI17B_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TI17B_HUMAN
pepdigest	swissprot:TI17B_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TI17B_HUMAN
pepinfo	swissprot:TI17B_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TI17B_HUMAN
pepnet	swissprot:TI17B_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TI17B_HUMAN
pepstats	swissprot:TI17B_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TI17B_HUMAN
pepwheel	swissprot:TI17B_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TI17B_HUMAN
pepwindow	swissprot:TI17B_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TI17B_HUMAN
sigcleave	swissprot:TI17B_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TI17B_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S2536_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q96CQ1-1; Sequence=Displayed; Name=2; IsoId=Q96CQ1-2; Sequence=VSP_026240, VSP_026241; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; IsoId=Q96CQ1-3; Sequence=VSP_026242; Note=No experimental confirmation available.; Name=4; IsoId=Q96CQ1-4; Sequence=VSP_035517; Note=Gene prediction based on EST data.; 
# BIOPHYSICOCHEMICAL PROPERTIES	S2536_HUMAN	Kinetic parameters  KM=1.19 mM for UTP (at 25 degrees Celsius) {ECO 0000269|PubMed 25320081}; KM=0.21 mM for CTP (at 25 degrees Celsius) {ECO 0000269|PubMed 25320081}; KM=2.5 mM for TTP (at 25 degrees Celsius) {ECO 0000269|PubMed 25320081}; KM=0.23 mM for GTP (at 25 degrees Celsius) {ECO 0000269|PubMed 25320081}; Vmax=30.7 umol/min/g enzyme toward UTP (at 25 degrees Celsius) {ECO 0000269|PubMed 25320081}; Vmax=51.2 umol/min/g enzyme toward CTP (at 25 degrees Celsius) {ECO 0000269|PubMed 25320081}; Vmax=8 umol/min/g enzyme toward TTP (at 25 degrees Celsius) {ECO 0000269|PubMed 25320081}; Vmax=23.6 umol/min/g enzyme toward GTP (at 25 degrees Celsius) {ECO 0000269|PubMed 25320081}; Note=The inhibitory constants (Ki) of these compounds are 1.3 um (UTP), 224 um (CTP), 276 um (GTP), and 181 um (ITP). CTP is the best substrate. {ECO 0000269|PubMed 25320081}; 
# BioGrid	120484	2
# CCDS	CCDS3114	-. [Q96CQ1-3]
# CCDS	CCDS46927	-. [Q96CQ1-1]
# ChiTaRS	SLC25A36	human
# Ensembl	ENST00000324194	ENSP00000320688; ENSG00000114120. [Q96CQ1-1]
# Ensembl	ENST00000446041	ENSP00000401938; ENSG00000114120. [Q96CQ1-3]
# Ensembl	ENST00000502594	ENSP00000423319; ENSG00000114120. [Q96CQ1-2]
# Ensembl	ENST00000631654	ENSP00000487839; ENSG00000114120. [Q96CQ1-2]
# ExpressionAtlas	Q96CQ1	baseline and differential
# FUNCTION	S2536_HUMAN	Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially cytosine and uracil (deoxy)nucleoside mono-, di-, and triphosphates by uniport and antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10- phenanthroline, tannic acid, and mercurials (mercury dichloride, Mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration. {ECO 0000269|PubMed 25320081}. 
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015218	pyrimidine nucleotide transmembrane transporter activity; IDA:UniProtKB.
# GO_process	GO:0000002	mitochondrial genome maintenance; IDA:UniProtKB.
# GO_process	GO:0006864	pyrimidine nucleotide transport; IDA:UniProtKB.
# GO_process	GO:0007005	mitochondrion organization; IDA:UniProtKB.
# GO_process	GO:0051881	regulation of mitochondrial membrane potential; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007005	mitochondrion organization
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.50.40.10	-; 1.
# Genevisible	Q96CQ1	HS
# HGNC	HGNC:25554	SLC25A36
# InterPro	IPR002067	Mit_carrier
# InterPro	IPR018108	Mitochondrial_sb/sol_carrier
# InterPro	IPR023395	Mt_carrier_dom
# KEGG_Brite	ko02001	Solute carrier family
# MIM	616149	gene
# Organism	S2536_HUMAN	Homo sapiens (Human)
# PRINTS	PR00926	MITOCARRIER
# PROSITE	PS50920	SOLCAR; 3
# Pfam	PF00153	Mito_carr; 3
# Proteomes	UP000005640	Chromosome 3
# RecName	S2536_HUMAN	Solute carrier family 25 member 36
# RefSeq	NP_001098117	NM_001104647.1. [Q96CQ1-1]
# RefSeq	NP_060625	NM_018155.2. [Q96CQ1-3]
# SIMILARITY	Belongs to the mitochondrial carrier (TC 2.A.29) family. {ECO	0000305}. 
# SIMILARITY	Contains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule	PRU00282}.
# SUBCELLULAR LOCATION	S2536_HUMAN	Mitochondrion inner membrane {ECO 0000305|PubMed 25320081}; Multi-pass membrane protein {ECO 0000255}. 
# SUPFAM	SSF103506	SSF103506
# TCDB	2.A.29.10	the mitochondrial carrier (mc) family
# TISSUE SPECIFICITY	Expressed at moderate level. {ECO:0000269|PubMed	17210862}. 
# UCSC	uc003etr	human. [Q96CQ1-1]
# eggNOG	ENOG410XS20	LUCA
# eggNOG	KOG0757	Eukaryota
BLAST	swissprot:S2536_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S2536_HUMAN
COXPRESdb	55186	http://coxpresdb.jp/data/gene/55186.shtml
CleanEx	HS_SLC25A36	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC25A36
DOI	10.1001/archopht.125.1.117	http://dx.doi.org/10.1001/archopht.125.1.117
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M114.610808	http://dx.doi.org/10.1074/jbc.M114.610808
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1101/gr.GR1547R	http://dx.doi.org/10.1101/gr.GR1547R
EMBL	AC108727	http://www.ebi.ac.uk/ena/data/view/AC108727
EMBL	AC132032	http://www.ebi.ac.uk/ena/data/view/AC132032
EMBL	AK001480	http://www.ebi.ac.uk/ena/data/view/AK001480
EMBL	AL136803	http://www.ebi.ac.uk/ena/data/view/AL136803
EMBL	BC014064	http://www.ebi.ac.uk/ena/data/view/BC014064
EMBL	BC019859	http://www.ebi.ac.uk/ena/data/view/BC019859
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
Ensembl	ENST00000324194	http://www.ensembl.org/id/ENST00000324194
Ensembl	ENST00000446041	http://www.ensembl.org/id/ENST00000446041
Ensembl	ENST00000502594	http://www.ensembl.org/id/ENST00000502594
Ensembl	ENST00000631654	http://www.ensembl.org/id/ENST00000631654
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015218	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015218
GO_process	GO:0000002	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000002
GO_process	GO:0006864	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006864
GO_process	GO:0007005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007005
GO_process	GO:0051881	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051881
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007005
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.50.40.10	http://www.cathdb.info/version/latest/superfamily/1.50.40.10
GeneCards	SLC25A36	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC25A36
GeneID	55186	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55186
GeneTree	ENSGT00550000074670	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074670
H-InvDB	HIX0021205	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0021205
HGNC	HGNC:25554	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:25554
HOGENOM	HOG000188210	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000188210&db=HOGENOM6
HOVERGEN	HBG059891	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG059891&db=HOVERGEN
HPA	HPA027036	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA027036
InParanoid	Q96CQ1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96CQ1
IntAct	Q96CQ1	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96CQ1*
InterPro	IPR002067	http://www.ebi.ac.uk/interpro/entry/IPR002067
InterPro	IPR018108	http://www.ebi.ac.uk/interpro/entry/IPR018108
InterPro	IPR023395	http://www.ebi.ac.uk/interpro/entry/IPR023395
Jabion	55186	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55186
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:55186	http://www.genome.jp/dbget-bin/www_bget?hsa:55186
KEGG_Orthology	KO:K15116	http://www.genome.jp/dbget-bin/www_bget?KO:K15116
MIM	616149	http://www.ncbi.nlm.nih.gov/omim/616149
MINT	MINT-1428592	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1428592
OMA	LNGIFDP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LNGIFDP
OrthoDB	EOG091G0BCW	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0BCW
PRINTS	PR00926	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00926
PROSITE	PS50920	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50920
PSORT	swissprot:S2536_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S2536_HUMAN
PSORT-B	swissprot:S2536_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S2536_HUMAN
PSORT2	swissprot:S2536_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S2536_HUMAN
Pfam	PF00153	http://pfam.xfam.org/family/PF00153
PharmGKB	PA142670908	http://www.pharmgkb.org/do/serve?objId=PA142670908&objCls=Gene
Phobius	swissprot:S2536_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S2536_HUMAN
PhylomeDB	Q96CQ1	http://phylomedb.org/?seqid=Q96CQ1
ProteinModelPortal	Q96CQ1	http://www.proteinmodelportal.org/query/uniprot/Q96CQ1
PubMed	11230166	http://www.ncbi.nlm.nih.gov/pubmed/11230166
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	17210862	http://www.ncbi.nlm.nih.gov/pubmed/17210862
PubMed	25320081	http://www.ncbi.nlm.nih.gov/pubmed/25320081
RefSeq	NP_001098117	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001098117
RefSeq	NP_060625	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060625
STRING	9606.ENSP00000320688	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000320688&targetmode=cogs
SUPFAM	SSF103506	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103506
TCDB	2.A.29.10	http://www.tcdb.org/search/result.php?tc=2.A.29.10
UCSC	uc003etr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003etr&org=rat
UniGene	Hs.144130	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.144130
UniProtKB	S2536_HUMAN	http://www.uniprot.org/uniprot/S2536_HUMAN
UniProtKB-AC	Q96CQ1	http://www.uniprot.org/uniprot/Q96CQ1
charge	swissprot:S2536_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S2536_HUMAN
eggNOG	ENOG410XS20	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS20
eggNOG	KOG0757	http://eggnogapi.embl.de/nog_data/html/tree/KOG0757
epestfind	swissprot:S2536_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S2536_HUMAN
garnier	swissprot:S2536_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S2536_HUMAN
helixturnhelix	swissprot:S2536_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S2536_HUMAN
hmoment	swissprot:S2536_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S2536_HUMAN
iep	swissprot:S2536_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S2536_HUMAN
inforesidue	swissprot:S2536_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S2536_HUMAN
neXtProt	NX_Q96CQ1	http://www.nextprot.org/db/entry/NX_Q96CQ1
octanol	swissprot:S2536_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S2536_HUMAN
pepcoil	swissprot:S2536_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S2536_HUMAN
pepdigest	swissprot:S2536_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S2536_HUMAN
pepinfo	swissprot:S2536_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S2536_HUMAN
pepnet	swissprot:S2536_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S2536_HUMAN
pepstats	swissprot:S2536_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S2536_HUMAN
pepwheel	swissprot:S2536_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S2536_HUMAN
pepwindow	swissprot:S2536_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S2536_HUMAN
sigcleave	swissprot:S2536_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S2536_HUMAN
## Database	ID	URL or Descriptions
# AltName	AT11B_HUMAN	ATPase IR
# AltName	AT11B_HUMAN	ATPase class VI type 11B
# AltName	AT11B_HUMAN	P4-ATPase flippase complex alpha subunit ATP11B
# BioGrid	116809	2
# CATALYTIC ACTIVITY	AT11B_HUMAN	ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). 
# ChiTaRS	ATP11B	human
# Ensembl	ENST00000323116	ENSP00000321195; ENSG00000058063
# ExpressionAtlas	Q9Y2G3	baseline and differential
# FUNCTION	AT11B_HUMAN	Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). Involved in regulation of sensitivity to cisplatin; may contribute to secretory vesicle transport of cisplatin from Golgi to plasma membrane. {ECO 0000269|PubMed 23585472, ECO 0000305}. 
# GO_component	GO:0005637	nuclear inner membrane; NAS:UniProtKB.
# GO_component	GO:0005769	early endosome; IEA:UniProtKB-SubCell.
# GO_component	GO:0005783	endoplasmic reticulum; IDA:UniProtKB.
# GO_component	GO:0005794	Golgi apparatus; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0055037	recycling endosome; IDA:UniProtKB.
# GO_component	GO:0055038	recycling endosome membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0000287	magnesium ion binding; IEA:InterPro.
# GO_function	GO:0004012	phospholipid-translocating ATPase activity; TAS:UniProtKB.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0015075	ion transmembrane transporter activity; NAS:UniProtKB.
# GO_process	GO:0006811	ion transport; NAS:UniProtKB.
# GO_process	GO:0015917	aminophospholipid transport; TAS:UniProtKB.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0045332	phospholipid translocation; NAS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# GOslim_process	GO:0061024	membrane organization
# Gene3D	2.70.150.10	-; 2.
# Gene3D	3.40.1110.10	-; 2.
# Gene3D	3.40.50.1000	-; 2.
# Genevisible	Q9Y2G3	HS
# HGNC	HGNC:13553	ATP11B
# InterPro	IPR001757	P_typ_ATPase
# InterPro	IPR006539	P-type_ATPase_IV
# InterPro	IPR008250	ATPase_P-typ_transduc_dom_A
# InterPro	IPR018303	ATPase_P-typ_P_site
# InterPro	IPR023214	HAD-like_dom
# InterPro	IPR023299	ATPase_P-typ_cyto_domN
# InterPro	IPR030362	ATP11B
# InterPro	IPR032630	P_typ_ATPase_c
# InterPro	IPR032631	P-type_ATPase_N
# KEGG_Brite	ko01000	Enzymes
# MIM	605869	gene
# MISCELLANEOUS	AT11B_HUMAN	Depletion of ATP11B by RNAi restores sensitivity of ovarian cancer cells to cisplatin. 
# Organism	AT11B_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR24092	PTHR24092
# PANTHER	PTHR24092:SF57	PTHR24092:SF57
# PIR	T42662	T42662
# PROSITE	PS00154	ATPASE_E1_E2
# Pfam	PF00122	E1-E2_ATPase
# Pfam	PF16209	PhoLip_ATPase_N
# Pfam	PF16212	PhoLip_ATPase_C
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-6798695	Neutrophil degranulation
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	AT11B_HUMAN	Probable phospholipid-transporting ATPase IF
# RefSeq	NP_055431	NM_014616.2
# SEQUENCE CAUTION	Sequence=AAH10630.1; Type=Frameshift; Positions=884; Evidence={ECO:0000305}; Sequence=AAH42180.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	AT11B_HUMAN	Recycling endosome membrane {ECO 0000269|PubMed 21914794}; Multi-pass membrane protein. Early endosome {ECO 0000269|PubMed 23585472}. Endoplasmic reticulum {ECO 0000269|PubMed 21914794}. Golgi apparatus, trans-Golgi network {ECO 0000269|PubMed 23585472}. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B (PubMed 21914794). In the presence of TMEM30A, mainly located in recycling endosomes (PubMed 21914794). {ECO 0000269|PubMed 21914794}. 
# SUBUNIT	Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit (Probable). Interacts with beta subunit TMEM30A. {ECO:0000269|PubMed	21914794, ECO:0000305}. 
# SUPFAM	SSF56784	SSF56784; 3
# SUPFAM	SSF81660	SSF81660; 2
# TCDB	3.A.3.8.12	the p-type atpase (p-atpase) superfamily
# TIGRFAMs	TIGR01494	ATPase_P-type; 3
# TIGRFAMs	TIGR01652	ATPase-Plipid
# UCSC	uc003fla	human
# eggNOG	COG0474	LUCA
# eggNOG	KOG0206	Eukaryota
BLAST	swissprot:AT11B_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AT11B_HUMAN
BioCyc	ZFISH:HS00716-MONOMER	http://biocyc.org/getid?id=ZFISH:HS00716-MONOMER
COXPRESdb	23200	http://coxpresdb.jp/data/gene/23200.shtml
CleanEx	HS_ATP11B	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP11B
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1074/jbc.M111.281006	http://dx.doi.org/10.1074/jbc.M111.281006
DOI	10.1074/jbc.M200240200	http://dx.doi.org/10.1074/jbc.M200240200
DOI	10.1093/dnares/6.1.63	http://dx.doi.org/10.1093/dnares/6.1.63
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1172/JCI65425	http://dx.doi.org/10.1172/JCI65425
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EC_number	EC:3.6.3.1	http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.1
EMBL	AB023173	http://www.ebi.ac.uk/ena/data/view/AB023173
EMBL	AC069431	http://www.ebi.ac.uk/ena/data/view/AC069431
EMBL	AF156548	http://www.ebi.ac.uk/ena/data/view/AF156548
EMBL	AL133061	http://www.ebi.ac.uk/ena/data/view/AL133061
EMBL	BC010630	http://www.ebi.ac.uk/ena/data/view/BC010630
EMBL	BC042180	http://www.ebi.ac.uk/ena/data/view/BC042180
ENZYME	3.6.3.1	http://enzyme.expasy.org/EC/3.6.3.1
Ensembl	ENST00000323116	http://www.ensembl.org/id/ENST00000323116
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005637	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005637
GO_component	GO:0005769	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005769
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0055037	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055037
GO_component	GO:0055038	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055038
GO_function	GO:0000287	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287
GO_function	GO:0004012	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004012
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0015075	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015075
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0015917	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015917
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0045332	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045332
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
Gene3D	2.70.150.10	http://www.cathdb.info/version/latest/superfamily/2.70.150.10
Gene3D	3.40.1110.10	http://www.cathdb.info/version/latest/superfamily/3.40.1110.10
Gene3D	3.40.50.1000	http://www.cathdb.info/version/latest/superfamily/3.40.50.1000
GeneCards	ATP11B	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP11B
GeneID	23200	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23200
GeneTree	ENSGT00860000133712	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00860000133712
HGNC	HGNC:13553	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13553
HOGENOM	HOG000202528	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202528&db=HOGENOM6
HOVERGEN	HBG050601	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050601&db=HOVERGEN
HPA	HPA036237	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA036237
HPA	HPA036238	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA036238
InParanoid	Q9Y2G3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y2G3
IntEnz	3.6.3.1	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.1
InterPro	IPR001757	http://www.ebi.ac.uk/interpro/entry/IPR001757
InterPro	IPR006539	http://www.ebi.ac.uk/interpro/entry/IPR006539
InterPro	IPR008250	http://www.ebi.ac.uk/interpro/entry/IPR008250
InterPro	IPR018303	http://www.ebi.ac.uk/interpro/entry/IPR018303
InterPro	IPR023214	http://www.ebi.ac.uk/interpro/entry/IPR023214
InterPro	IPR023299	http://www.ebi.ac.uk/interpro/entry/IPR023299
InterPro	IPR030362	http://www.ebi.ac.uk/interpro/entry/IPR030362
InterPro	IPR032630	http://www.ebi.ac.uk/interpro/entry/IPR032630
InterPro	IPR032631	http://www.ebi.ac.uk/interpro/entry/IPR032631
Jabion	23200	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=23200
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:23200	http://www.genome.jp/dbget-bin/www_bget?hsa:23200
KEGG_Orthology	KO:K01530	http://www.genome.jp/dbget-bin/www_bget?KO:K01530
MIM	605869	http://www.ncbi.nlm.nih.gov/omim/605869
OMA	TNTEKAQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TNTEKAQ
OrthoDB	EOG091G03B1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G03B1
PANTHER	PTHR24092	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24092
PANTHER	PTHR24092:SF57	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24092:SF57
PROSITE	PS00154	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00154
PSORT	swissprot:AT11B_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AT11B_HUMAN
PSORT-B	swissprot:AT11B_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AT11B_HUMAN
PSORT2	swissprot:AT11B_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AT11B_HUMAN
Pfam	PF00122	http://pfam.xfam.org/family/PF00122
Pfam	PF16209	http://pfam.xfam.org/family/PF16209
Pfam	PF16212	http://pfam.xfam.org/family/PF16212
PharmGKB	PA25102	http://www.pharmgkb.org/do/serve?objId=PA25102&objCls=Gene
Phobius	swissprot:AT11B_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AT11B_HUMAN
PhylomeDB	Q9Y2G3	http://phylomedb.org/?seqid=Q9Y2G3
ProteinModelPortal	Q9Y2G3	http://www.proteinmodelportal.org/query/uniprot/Q9Y2G3
PubMed	10231032	http://www.ncbi.nlm.nih.gov/pubmed/10231032
PubMed	11015572	http://www.ncbi.nlm.nih.gov/pubmed/11015572
PubMed	11790799	http://www.ncbi.nlm.nih.gov/pubmed/11790799
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	21914794	http://www.ncbi.nlm.nih.gov/pubmed/21914794
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	23585472	http://www.ncbi.nlm.nih.gov/pubmed/23585472
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
Reactome	R-HSA-6798695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6798695
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_055431	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055431
STRING	9606.ENSP00000321195	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000321195&targetmode=cogs
SUPFAM	SSF56784	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784
SUPFAM	SSF81660	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81660
TCDB	3.A.3.8.12	http://www.tcdb.org/search/result.php?tc=3.A.3.8.12
TIGRFAMs	TIGR01494	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01494
TIGRFAMs	TIGR01652	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01652
UCSC	uc003fla	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003fla&org=rat
UniGene	Hs.478429	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.478429
UniProtKB	AT11B_HUMAN	http://www.uniprot.org/uniprot/AT11B_HUMAN
UniProtKB-AC	Q9Y2G3	http://www.uniprot.org/uniprot/Q9Y2G3
charge	swissprot:AT11B_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AT11B_HUMAN
eggNOG	COG0474	http://eggnogapi.embl.de/nog_data/html/tree/COG0474
eggNOG	KOG0206	http://eggnogapi.embl.de/nog_data/html/tree/KOG0206
epestfind	swissprot:AT11B_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AT11B_HUMAN
garnier	swissprot:AT11B_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AT11B_HUMAN
helixturnhelix	swissprot:AT11B_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AT11B_HUMAN
hmoment	swissprot:AT11B_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AT11B_HUMAN
iep	swissprot:AT11B_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AT11B_HUMAN
inforesidue	swissprot:AT11B_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AT11B_HUMAN
neXtProt	NX_Q9Y2G3	http://www.nextprot.org/db/entry/NX_Q9Y2G3
octanol	swissprot:AT11B_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AT11B_HUMAN
pepcoil	swissprot:AT11B_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AT11B_HUMAN
pepdigest	swissprot:AT11B_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AT11B_HUMAN
pepinfo	swissprot:AT11B_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AT11B_HUMAN
pepnet	swissprot:AT11B_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AT11B_HUMAN
pepstats	swissprot:AT11B_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AT11B_HUMAN
pepwheel	swissprot:AT11B_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AT11B_HUMAN
pepwindow	swissprot:AT11B_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AT11B_HUMAN
sigcleave	swissprot:AT11B_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AT11B_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SLC31_HUMAN	Event=Alternative splicing; Named isoforms=7; Name=A; IsoId=Q07837-1; Sequence=Displayed; Name=B; IsoId=Q07837-2; Sequence=VSP_054339; Name=C; IsoId=Q07837-3; Sequence=VSP_054342, VSP_054343; Name=D; IsoId=Q07837-4; Sequence=VSP_054340, VSP_054341; Name=E; IsoId=Q07837-5; Sequence=VSP_054344, VSP_054345; Name=F; IsoId=Q07837-6; Sequence=VSP_054346, VSP_054349; Name=G; IsoId=Q07837-7; Sequence=VSP_054347, VSP_054348; 
# AltName	SLC31_HUMAN	D2h
# AltName	SLC31_HUMAN	Solute carrier family 3 member 1
# AltName	SLC31_HUMAN	b(0,+)-type amino acid transport protein
# CAZy	GH13	Glycoside Hydrolase Family 13
# CCDS	CCDS1819	-. [Q07837-1]
# ChiTaRS	SLC3A1	human
# DISEASE	SLC31_HUMAN	Cystinuria (CSNU) [MIM 220100]  An autosomal disorder characterized by impaired epithelial cell transport of cystine and dibasic amino acids (lysine, ornithine, and arginine) in the proximal renal tubule and gastrointestinal tract. The impaired renal reabsorption of cystine and its low solubility causes the formation of calculi in the urinary tract, resulting in obstructive uropathy, pyelonephritis, and, rarely, renal failure. {ECO 0000269|PubMed 10738006, ECO 0000269|PubMed 11748844, ECO 0000269|PubMed 12234283, ECO 0000269|PubMed 15635077, ECO 0000269|PubMed 16138908, ECO 0000269|PubMed 16609684, ECO 0000269|PubMed 19782624, ECO 0000269|PubMed 7539209, ECO 0000269|PubMed 7573036, ECO 0000269|PubMed 7575432, ECO 0000269|PubMed 8054986, ECO 0000269|PubMed 9186880}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SLC31_HUMAN	Hypotonia-cystinuria syndrome (HCS) [MIM 606407]  Characterized generalized hypotonia at birth, nephrolithiasis, growth hormone deficiency, minor facial dysmorphism, failure to thrive, followed by hyperphagia and rapid weight gain in late childhood. {ECO 0000269|PubMed 16385448}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00138	L-Cystine
# Ensembl	ENST00000260649	ENSP00000260649; ENSG00000138079. [Q07837-1]
# Ensembl	ENST00000409229	ENSP00000386620; ENSG00000138079. [Q07837-6]
# Ensembl	ENST00000409380	ENSP00000386709; ENSG00000138079. [Q07837-2]
# Ensembl	ENST00000409740	ENSP00000386677; ENSG00000138079. [Q07837-4]
# Ensembl	ENST00000409741	ENSP00000386954; ENSG00000138079. [Q07837-5]
# Ensembl	ENST00000410056	ENSP00000387337; ENSG00000138079. [Q07837-3]
# ExpressionAtlas	Q07837	baseline and differential
# FUNCTION	SLC31_HUMAN	Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule. {ECO 0000269|PubMed 11318953, ECO 0000269|PubMed 7686906, ECO 0000269|PubMed 8486766, ECO 0000269|PubMed 8663184}. 
# GO_component	GO:0005743	mitochondrial inner membrane; IEA:Ensembl.
# GO_component	GO:0005774	vacuolar membrane; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0031526	brush border membrane; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0003824	catalytic activity; IEA:InterPro.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0015174	basic amino acid transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0015184	L-cystine transmembrane transporter activity; TAS:ProtInc.
# GO_process	GO:0005975	carbohydrate metabolic process; IEA:InterPro.
# GO_process	GO:0006520	cellular amino acid metabolic process; TAS:ProtInc.
# GO_process	GO:0006865	amino acid transport; TAS:Reactome.
# GO_process	GO:0015802	basic amino acid transport; TAS:ProtInc.
# GO_process	GO:0015811	L-cystine transport; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0005975	carbohydrate metabolic process
# GOslim_process	GO:0006520	cellular amino acid metabolic process
# GOslim_process	GO:0006810	transport
# Gene3D	3.20.20.80	-; 2.
# Genevisible	Q07837	HS
# HGNC	HGNC:11025	SLC3A1
# InterPro	IPR006047	Glyco_hydro_13_cat_dom
# InterPro	IPR013781	Glyco_hydro_catalytic_dom
# InterPro	IPR015902	Glyco_hydro_13
# InterPro	IPR017853	Glycoside_hydrolase_SF
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H00901	[Inherited metabolic disease; Urinary system disease; Kidney disease] Cystinuria
# KEGG_Pathway	ko04974	Protein digestion and absorption
# MIM	104614	gene
# MIM	220100	phenotype
# MIM	606407	phenotype
# Organism	SLC31_HUMAN	Homo sapiens (Human)
# Orphanet	163690	Hypotonia - cystinuria syndrome
# Orphanet	163693	2p21 microdeletion syndrome
# Orphanet	238523	Atypical hypotonia - cystinuria syndrome
# Orphanet	93612	Cystinuria type A
# PANTHER	PTHR10357	PTHR10357; 2
# PIR	A47102	A47102
# Pfam	PF00128	Alpha-amylase
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-352230	Amino acid transport across the plasma membrane
# RecName	SLC31_HUMAN	Neutral and basic amino acid transport protein rBAT
# RefSeq	NP_000332	NM_000341.3. [Q07837-1]
# SMART	SM00642	Aamy
# SUBCELLULAR LOCATION	SLC31_HUMAN	Membrane {ECO 0000269|PubMed 12167606}; Single-pass type II membrane protein {ECO 0000269|PubMed 12167606}. 
# SUBUNIT	SLC31_HUMAN	Disulfide-linked heterodimer with the amino acid transport protein SLC7A9. {ECO 0000269|PubMed 10588648, ECO 0000269|PubMed 12167606}. 
# SUPFAM	SSF51445	SSF51445
# TCDB	8.A.9.1	the rbat transport accessory protein (rbat) family
# TISSUE SPECIFICITY	SLC31_HUMAN	Expressed in the brush border membrane in the kidney (at protein level). Predominantly expressed in the kidney, small intestine and pancreas. Weakly expressed in liver. {ECO 0000269|PubMed 12167606, ECO 0000269|PubMed 7686906, ECO 0000269|PubMed 8486766}. 
# UCSC	uc002rty	human. [Q07837-1]
# WEB RESOURCE	SLC31_HUMAN	Name=Cysdb; Note=Cystinuria database; URL="http //www.cysdb.mcgill.ca/";
# eggNOG	COG0366	LUCA
# eggNOG	KOG0471	Eukaryota
BLAST	swissprot:SLC31_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SLC31_HUMAN
BioCyc	ZFISH:ENSG00000138079-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000138079-MONOMER
COXPRESdb	6519	http://coxpresdb.jp/data/gene/6519.shtml
CleanEx	HS_SLC3A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC3A1
DOI	10.1002/(SICI)1098-1004(200004)15:4<390::AID-HUMU33>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(200004)15:4<390::AID-HUMU33>3.0.CO
DOI	10.1002/humu.1228	http://dx.doi.org/10.1002/humu.1228
DOI	10.1016/j.ygeno.2005.04.001	http://dx.doi.org/10.1016/j.ygeno.2005.04.001
DOI	10.1016/j.ymgme.2009.09.001	http://dx.doi.org/10.1016/j.ymgme.2009.09.001
DOI	10.1038/ki.1997.258	http://dx.doi.org/10.1038/ki.1997.258
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng0494-420	http://dx.doi.org/10.1038/ng0494-420
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.ki.5000241	http://dx.doi.org/10.1038/sj.ki.5000241
DOI	10.1042/bj3100951	http://dx.doi.org/10.1042/bj3100951
DOI	10.1046/j.1523-1755.2001.0590051821.x	http://dx.doi.org/10.1046/j.1523-1755.2001.0590051821.x
DOI	10.1046/j.1523-1755.2002.00552.x	http://dx.doi.org/10.1046/j.1523-1755.2002.00552.x
DOI	10.1073/pnas.92.21.9667	http://dx.doi.org/10.1073/pnas.92.21.9667
DOI	10.1074/jbc.271.28.16758	http://dx.doi.org/10.1074/jbc.271.28.16758
DOI	10.1086/498852	http://dx.doi.org/10.1086/498852
DOI	10.1091/mbc.10.12.4135	http://dx.doi.org/10.1091/mbc.10.12.4135
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1529-8817.2005.00185.x	http://dx.doi.org/10.1111/j.1529-8817.2005.00185.x
DOI	10.1136/jmg.2004.022244	http://dx.doi.org/10.1136/jmg.2004.022244
DOI	10.1172/JCI116415	http://dx.doi.org/10.1172/JCI116415
DrugBank	DB00138	http://www.drugbank.ca/drugs/DB00138
EMBL	AB033549	http://www.ebi.ac.uk/ena/data/view/AB033549
EMBL	AC013717	http://www.ebi.ac.uk/ena/data/view/AC013717
EMBL	AK223146	http://www.ebi.ac.uk/ena/data/view/AK223146
EMBL	AK289636	http://www.ebi.ac.uk/ena/data/view/AK289636
EMBL	BC022386	http://www.ebi.ac.uk/ena/data/view/BC022386
EMBL	BC093624	http://www.ebi.ac.uk/ena/data/view/BC093624
EMBL	BC093626	http://www.ebi.ac.uk/ena/data/view/BC093626
EMBL	D82326	http://www.ebi.ac.uk/ena/data/view/D82326
EMBL	DQ023512	http://www.ebi.ac.uk/ena/data/view/DQ023512
EMBL	DQ023513	http://www.ebi.ac.uk/ena/data/view/DQ023513
EMBL	DQ023514	http://www.ebi.ac.uk/ena/data/view/DQ023514
EMBL	DQ023515	http://www.ebi.ac.uk/ena/data/view/DQ023515
EMBL	DQ023516	http://www.ebi.ac.uk/ena/data/view/DQ023516
EMBL	DQ023517	http://www.ebi.ac.uk/ena/data/view/DQ023517
EMBL	L11696	http://www.ebi.ac.uk/ena/data/view/L11696
EMBL	M95548	http://www.ebi.ac.uk/ena/data/view/M95548
EMBL	U60810	http://www.ebi.ac.uk/ena/data/view/U60810
EMBL	U60811	http://www.ebi.ac.uk/ena/data/view/U60811
EMBL	U60812	http://www.ebi.ac.uk/ena/data/view/U60812
EMBL	U60813	http://www.ebi.ac.uk/ena/data/view/U60813
EMBL	U60814	http://www.ebi.ac.uk/ena/data/view/U60814
EMBL	U60815	http://www.ebi.ac.uk/ena/data/view/U60815
EMBL	U60816	http://www.ebi.ac.uk/ena/data/view/U60816
EMBL	U60818	http://www.ebi.ac.uk/ena/data/view/U60818
EMBL	U60819	http://www.ebi.ac.uk/ena/data/view/U60819
Ensembl	ENST00000260649	http://www.ensembl.org/id/ENST00000260649
Ensembl	ENST00000409229	http://www.ensembl.org/id/ENST00000409229
Ensembl	ENST00000409380	http://www.ensembl.org/id/ENST00000409380
Ensembl	ENST00000409740	http://www.ensembl.org/id/ENST00000409740
Ensembl	ENST00000409741	http://www.ensembl.org/id/ENST00000409741
Ensembl	ENST00000410056	http://www.ensembl.org/id/ENST00000410056
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005774	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005774
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0031526	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031526
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0003824	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003824
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_function	GO:0015174	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015174
GO_function	GO:0015184	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015184
GO_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GO_process	GO:0006520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GO_process	GO:0015802	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015802
GO_process	GO:0015811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015811
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GOslim_process	GO:0006520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
Gene3D	3.20.20.80	http://www.cathdb.info/version/latest/superfamily/3.20.20.80
GeneCards	SLC3A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC3A1
GeneID	6519	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6519
GeneTree	ENSGT00860000133838	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00860000133838
HGNC	HGNC:11025	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11025
HOGENOM	HOG000220640	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220640&db=HOGENOM6
HOVERGEN	HBG053002	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053002&db=HOVERGEN
HPA	HPA038360	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA038360
InParanoid	Q07837	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q07837
InterPro	IPR006047	http://www.ebi.ac.uk/interpro/entry/IPR006047
InterPro	IPR013781	http://www.ebi.ac.uk/interpro/entry/IPR013781
InterPro	IPR015902	http://www.ebi.ac.uk/interpro/entry/IPR015902
InterPro	IPR017853	http://www.ebi.ac.uk/interpro/entry/IPR017853
Jabion	6519	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6519
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00901	http://www.genome.jp/dbget-bin/www_bget?H00901
KEGG_Gene	hsa:6519	http://www.genome.jp/dbget-bin/www_bget?hsa:6519
KEGG_Orthology	KO:K14210	http://www.genome.jp/dbget-bin/www_bget?KO:K14210
KEGG_Pathway	ko04974	http://www.genome.jp/kegg-bin/show_pathway?ko04974
MIM	104614	http://www.ncbi.nlm.nih.gov/omim/104614
MIM	220100	http://www.ncbi.nlm.nih.gov/omim/220100
MIM	606407	http://www.ncbi.nlm.nih.gov/omim/606407
OMA	EYATDPR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EYATDPR
Orphanet	163690	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=163690
Orphanet	163693	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=163693
Orphanet	238523	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=238523
Orphanet	93612	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=93612
OrthoDB	EOG091G03FE	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G03FE
PANTHER	PTHR10357	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10357
PSORT	swissprot:SLC31_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SLC31_HUMAN
PSORT-B	swissprot:SLC31_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SLC31_HUMAN
PSORT2	swissprot:SLC31_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SLC31_HUMAN
Pfam	PF00128	http://pfam.xfam.org/family/PF00128
PharmGKB	PA35893	http://www.pharmgkb.org/do/serve?objId=PA35893&objCls=Gene
Phobius	swissprot:SLC31_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SLC31_HUMAN
PhylomeDB	Q07837	http://phylomedb.org/?seqid=Q07837
ProteinModelPortal	Q07837	http://www.proteinmodelportal.org/query/uniprot/Q07837
PubMed	10588648	http://www.ncbi.nlm.nih.gov/pubmed/10588648
PubMed	10738006	http://www.ncbi.nlm.nih.gov/pubmed/10738006
PubMed	11318953	http://www.ncbi.nlm.nih.gov/pubmed/11318953
PubMed	11748844	http://www.ncbi.nlm.nih.gov/pubmed/11748844
PubMed	12167606	http://www.ncbi.nlm.nih.gov/pubmed/12167606
PubMed	12234283	http://www.ncbi.nlm.nih.gov/pubmed/12234283
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15635077	http://www.ncbi.nlm.nih.gov/pubmed/15635077
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	15913950	http://www.ncbi.nlm.nih.gov/pubmed/15913950
PubMed	16138908	http://www.ncbi.nlm.nih.gov/pubmed/16138908
PubMed	16385448	http://www.ncbi.nlm.nih.gov/pubmed/16385448
PubMed	16609684	http://www.ncbi.nlm.nih.gov/pubmed/16609684
PubMed	19782624	http://www.ncbi.nlm.nih.gov/pubmed/19782624
PubMed	7539209	http://www.ncbi.nlm.nih.gov/pubmed/7539209
PubMed	7568194	http://www.ncbi.nlm.nih.gov/pubmed/7568194
PubMed	7573036	http://www.ncbi.nlm.nih.gov/pubmed/7573036
PubMed	7575432	http://www.ncbi.nlm.nih.gov/pubmed/7575432
PubMed	7686906	http://www.ncbi.nlm.nih.gov/pubmed/7686906
PubMed	8054986	http://www.ncbi.nlm.nih.gov/pubmed/8054986
PubMed	8486766	http://www.ncbi.nlm.nih.gov/pubmed/8486766
PubMed	8663184	http://www.ncbi.nlm.nih.gov/pubmed/8663184
PubMed	9186880	http://www.ncbi.nlm.nih.gov/pubmed/9186880
Reactome	R-HSA-352230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-352230
RefSeq	NP_000332	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000332
SMART	SM00642	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00642
STRING	9606.ENSP00000260649	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000260649&targetmode=cogs
SUPFAM	SSF51445	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51445
TCDB	8.A.9.1	http://www.tcdb.org/search/result.php?tc=8.A.9.1
UCSC	uc002rty	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002rty&org=rat
UniGene	Hs.112916	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.112916
UniProtKB	SLC31_HUMAN	http://www.uniprot.org/uniprot/SLC31_HUMAN
UniProtKB-AC	Q07837	http://www.uniprot.org/uniprot/Q07837
charge	swissprot:SLC31_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SLC31_HUMAN
eggNOG	COG0366	http://eggnogapi.embl.de/nog_data/html/tree/COG0366
eggNOG	KOG0471	http://eggnogapi.embl.de/nog_data/html/tree/KOG0471
epestfind	swissprot:SLC31_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SLC31_HUMAN
garnier	swissprot:SLC31_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SLC31_HUMAN
helixturnhelix	swissprot:SLC31_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SLC31_HUMAN
hmoment	swissprot:SLC31_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SLC31_HUMAN
iep	swissprot:SLC31_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SLC31_HUMAN
inforesidue	swissprot:SLC31_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SLC31_HUMAN
neXtProt	NX_Q07837	http://www.nextprot.org/db/entry/NX_Q07837
octanol	swissprot:SLC31_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SLC31_HUMAN
pepcoil	swissprot:SLC31_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SLC31_HUMAN
pepdigest	swissprot:SLC31_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SLC31_HUMAN
pepinfo	swissprot:SLC31_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SLC31_HUMAN
pepnet	swissprot:SLC31_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SLC31_HUMAN
pepstats	swissprot:SLC31_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SLC31_HUMAN
pepwheel	swissprot:SLC31_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SLC31_HUMAN
pepwindow	swissprot:SLC31_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SLC31_HUMAN
sigcleave	swissprot:SLC31_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SLC31_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GRID2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O43424-1; Sequence=Displayed; Name=2; IsoId=O43424-2; Sequence=VSP_054704; 
# BioGrid	109152	7
# CCDS	CCDS3637	-. [O43424-1]
# CCDS	CCDS68758	-. [O43424-2]
# ChiTaRS	GRID2	human
# DISEASE	GRID2_HUMAN	Spinocerebellar ataxia, autosomal recessive, 18 (SCAR18) [MIM 616204]  Spinocerebellar ataxia defines a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR18 features include progressive cerebellar atrophy, delayed psychomotor development, severely impaired gait, ocular movement abnormalities, and intellectual disability. {ECO 0000269|PubMed 23611888, ECO 0000269|PubMed 24078737, ECO 0000269|PubMed 25841024}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	GRID2_HUMAN	The PDZ-binding motif mediates interaction with GOPC. {ECO 0000250}. 
# Ensembl	ENST00000282020	ENSP00000282020; ENSG00000152208. [O43424-1]
# Ensembl	ENST00000510992	ENSP00000421257; ENSG00000152208. [O43424-2]
# ExpressionAtlas	O43424	baseline and differential
# FUNCTION	GRID2_HUMAN	Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. 
# GO_component	GO:0005886	plasma membrane; ISS:BHF-UCL.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0008328	ionotropic glutamate receptor complex; ISS:BHF-UCL.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0043197	dendritic spine; ISS:BHF-UCL.
# GO_component	GO:0045202	synapse; ISS:BHF-UCL.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0004970	ionotropic glutamate receptor activity; IEA:InterPro.
# GO_function	GO:0005234	extracellular-glutamate-gated ion channel activity; IEA:InterPro.
# GO_function	GO:0008066	glutamate receptor activity; TAS:ProtInc.
# GO_function	GO:0030165	PDZ domain binding; ISS:BHF-UCL.
# GO_function	GO:0097110	scaffold protein binding; ISS:BHF-UCL.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; ISS:BHF-UCL.
# GO_process	GO:0007215	glutamate receptor signaling pathway; TAS:ProtInc.
# GO_process	GO:0010975	regulation of neuron projection development; IEA:Ensembl.
# GO_process	GO:0021707	cerebellar granule cell differentiation; ISS:BHF-UCL.
# GO_process	GO:0034613	cellular protein localization; ISS:BHF-UCL.
# GO_process	GO:0035249	synaptic transmission, glutamatergic; ISS:BHF-UCL.
# GO_process	GO:0043523	regulation of neuron apoptotic process; ISS:BHF-UCL.
# GO_process	GO:0060079	excitatory postsynaptic potential; ISS:BHF-UCL.
# GO_process	GO:0060134	prepulse inhibition; ISS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007155	cell adhesion
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0030154	cell differentiation
# Genevisible	O43424	HS
# HGNC	HGNC:4576	GRID2
# InterPro	IPR001320	Iontro_rcpt
# InterPro	IPR001508	Iono_rcpt_met
# InterPro	IPR001828	ANF_lig-bd_rcpt
# InterPro	IPR019594	Glu/Gly-bd
# InterPro	IPR028082	Peripla_BP_I
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04730	Long-term depression
# MIM	602368	gene
# MIM	616204	phenotype
# Organism	GRID2_HUMAN	Homo sapiens (Human)
# Orphanet	363432	Autosomal recessive congenital cerebellar ataxia due to GRID2 deficiency
# PDB	5KC8	X-ray; 1.75 A; A=24-440
# PDB	5KCA	X-ray; 3.10 A; A=24-440
# PRINTS	PR00177	NMDARECEPTOR
# Pfam	PF00060	Lig_chan
# Pfam	PF01094	ANF_receptor
# Pfam	PF10613	Lig_chan-Glu_bd
# Proteomes	UP000005640	Chromosome 4
# RecName	GRID2_HUMAN	Glutamate receptor ionotropic, delta-2
# RefSeq	NP_001273767	NM_001286838.1. [O43424-2]
# RefSeq	NP_001501	NM_001510.3. [O43424-1]
# SEQUENCE CAUTION	Sequence=BAD92555.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID2 subfamily. {ECO	0000305}. 
# SMART	SM00079	PBPe
# SMART	SM00918	Lig_chan-Glu_bd
# SUBCELLULAR LOCATION	GRID2_HUMAN	Cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUBUNIT	Interacts with AIP1, AP4M1, BECN1, GOPC, GRID2IP, SHANK1 and SHANK2. Interacts with EML2 (By similarity). Interacts with CBLN1 and CBLN2, but not with CBLN4. CBLN1-binding is calcium- independent (By similarity). {ECO	0000250}. 
# SUPFAM	SSF53822	SSF53822
# UCSC	uc011cdt	human. [O43424-1]
# eggNOG	ENOG410ISR9	Eukaryota
# eggNOG	ENOG410YYDD	LUCA
BLAST	swissprot:GRID2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GRID2_HUMAN
COXPRESdb	2895	http://coxpresdb.jp/data/gene/2895.shtml
CleanEx	HS_GRID2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GRID2
DOI	10.1006/geno.1997.5108	http://dx.doi.org/10.1006/geno.1997.5108
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1177/0883073813484967	http://dx.doi.org/10.1177/0883073813484967
DOI	10.1212/WNL.0000000000001524	http://dx.doi.org/10.1212/WNL.0000000000001524
DOI	10.1212/WNL.0b013e3182a841a3	http://dx.doi.org/10.1212/WNL.0b013e3182a841a3
EMBL	AB209318	http://www.ebi.ac.uk/ena/data/view/AB209318
EMBL	AC020699	http://www.ebi.ac.uk/ena/data/view/AC020699
EMBL	AC022317	http://www.ebi.ac.uk/ena/data/view/AC022317
EMBL	AC093596	http://www.ebi.ac.uk/ena/data/view/AC093596
EMBL	AC093733	http://www.ebi.ac.uk/ena/data/view/AC093733
EMBL	AC095059	http://www.ebi.ac.uk/ena/data/view/AC095059
EMBL	AC096769	http://www.ebi.ac.uk/ena/data/view/AC096769
EMBL	AC104077	http://www.ebi.ac.uk/ena/data/view/AC104077
EMBL	AC105315	http://www.ebi.ac.uk/ena/data/view/AC105315
EMBL	AC105452	http://www.ebi.ac.uk/ena/data/view/AC105452
EMBL	AC108158	http://www.ebi.ac.uk/ena/data/view/AC108158
EMBL	AC110800	http://www.ebi.ac.uk/ena/data/view/AC110800
EMBL	AC112695	http://www.ebi.ac.uk/ena/data/view/AC112695
EMBL	AC115111	http://www.ebi.ac.uk/ena/data/view/AC115111
EMBL	AC115537	http://www.ebi.ac.uk/ena/data/view/AC115537
EMBL	AF009014	http://www.ebi.ac.uk/ena/data/view/AF009014
EMBL	BC099652	http://www.ebi.ac.uk/ena/data/view/BC099652
EMBL	BC099653	http://www.ebi.ac.uk/ena/data/view/BC099653
EMBL	BC099654	http://www.ebi.ac.uk/ena/data/view/BC099654
Ensembl	ENST00000282020	http://www.ensembl.org/id/ENST00000282020
Ensembl	ENST00000510992	http://www.ensembl.org/id/ENST00000510992
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0008328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008328
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0043197	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043197
GO_component	GO:0045202	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045202
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0004970	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004970
GO_function	GO:0005234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005234
GO_function	GO:0008066	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008066
GO_function	GO:0030165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030165
GO_function	GO:0097110	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097110
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007157	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007157
GO_process	GO:0007215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007215
GO_process	GO:0010975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010975
GO_process	GO:0021707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021707
GO_process	GO:0034613	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034613
GO_process	GO:0035249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035249
GO_process	GO:0043523	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043523
GO_process	GO:0060079	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060079
GO_process	GO:0060134	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060134
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GeneCards	GRID2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GRID2
GeneID	2895	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2895
GeneTree	ENSGT00760000118920	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118920
H-InvDB	HIX0031353	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0031353
HGNC	HGNC:4576	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4576
HOGENOM	HOG000264260	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264260&db=HOGENOM6
HOVERGEN	HBG051840	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051840&db=HOVERGEN
HPA	HPA056253	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA056253
HPA	HPA058538	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA058538
InParanoid	O43424	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O43424
InterPro	IPR001320	http://www.ebi.ac.uk/interpro/entry/IPR001320
InterPro	IPR001508	http://www.ebi.ac.uk/interpro/entry/IPR001508
InterPro	IPR001828	http://www.ebi.ac.uk/interpro/entry/IPR001828
InterPro	IPR019594	http://www.ebi.ac.uk/interpro/entry/IPR019594
InterPro	IPR028082	http://www.ebi.ac.uk/interpro/entry/IPR028082
Jabion	2895	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2895
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:2895	http://www.genome.jp/dbget-bin/www_bget?hsa:2895
KEGG_Orthology	KO:K05207	http://www.genome.jp/dbget-bin/www_bget?KO:K05207
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04730	http://www.genome.jp/kegg-bin/show_pathway?ko04730
MIM	602368	http://www.ncbi.nlm.nih.gov/omim/602368
MIM	616204	http://www.ncbi.nlm.nih.gov/omim/616204
MINT	MINT-257823	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-257823
OMA	HGNYAFV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HGNYAFV
Orphanet	363432	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=363432
OrthoDB	EOG091G010L	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G010L
PDB	5KC8	http://www.ebi.ac.uk/pdbe-srv/view/entry/5KC8
PDB	5KCA	http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCA
PDBsum	5KC8	http://www.ebi.ac.uk/pdbsum/5KC8
PDBsum	5KCA	http://www.ebi.ac.uk/pdbsum/5KCA
PRINTS	PR00177	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00177
PSORT	swissprot:GRID2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GRID2_HUMAN
PSORT-B	swissprot:GRID2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GRID2_HUMAN
PSORT2	swissprot:GRID2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GRID2_HUMAN
Pfam	PF00060	http://pfam.xfam.org/family/PF00060
Pfam	PF01094	http://pfam.xfam.org/family/PF01094
Pfam	PF10613	http://pfam.xfam.org/family/PF10613
PharmGKB	PA28971	http://www.pharmgkb.org/do/serve?objId=PA28971&objCls=Gene
Phobius	swissprot:GRID2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GRID2_HUMAN
PhylomeDB	O43424	http://phylomedb.org/?seqid=O43424
ProteinModelPortal	O43424	http://www.proteinmodelportal.org/query/uniprot/O43424
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	23611888	http://www.ncbi.nlm.nih.gov/pubmed/23611888
PubMed	24078737	http://www.ncbi.nlm.nih.gov/pubmed/24078737
PubMed	25841024	http://www.ncbi.nlm.nih.gov/pubmed/25841024
PubMed	9465309	http://www.ncbi.nlm.nih.gov/pubmed/9465309
RefSeq	NP_001273767	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273767
RefSeq	NP_001501	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001501
SMART	SM00079	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00079
SMART	SM00918	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00918
SMR	O43424	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O43424
STRING	9606.ENSP00000282020	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000282020&targetmode=cogs
SUPFAM	SSF53822	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822
UCSC	uc011cdt	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc011cdt&org=rat
UniGene	Hs.162727	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.162727
UniGene	Hs.480281	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.480281
UniProtKB	GRID2_HUMAN	http://www.uniprot.org/uniprot/GRID2_HUMAN
UniProtKB-AC	O43424	http://www.uniprot.org/uniprot/O43424
charge	swissprot:GRID2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GRID2_HUMAN
eggNOG	ENOG410ISR9	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ISR9
eggNOG	ENOG410YYDD	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YYDD
epestfind	swissprot:GRID2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GRID2_HUMAN
garnier	swissprot:GRID2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GRID2_HUMAN
helixturnhelix	swissprot:GRID2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GRID2_HUMAN
hmoment	swissprot:GRID2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GRID2_HUMAN
iep	swissprot:GRID2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GRID2_HUMAN
inforesidue	swissprot:GRID2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GRID2_HUMAN
neXtProt	NX_O43424	http://www.nextprot.org/db/entry/NX_O43424
octanol	swissprot:GRID2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GRID2_HUMAN
pepcoil	swissprot:GRID2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GRID2_HUMAN
pepdigest	swissprot:GRID2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GRID2_HUMAN
pepinfo	swissprot:GRID2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GRID2_HUMAN
pepnet	swissprot:GRID2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GRID2_HUMAN
pepstats	swissprot:GRID2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GRID2_HUMAN
pepwheel	swissprot:GRID2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GRID2_HUMAN
pepwindow	swissprot:GRID2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GRID2_HUMAN
sigcleave	swissprot:GRID2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GRID2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AP4B1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y6B7-1; Sequence=Displayed; Name=2; IsoId=Q9Y6B7-2; Sequence=VSP_055787, VSP_055788, VSP_055789; Note=No experimental confirmation available.; 
# AltName	AP4B1_HUMAN	AP-4 adaptor complex subunit beta
# AltName	AP4B1_HUMAN	Adaptor-related protein complex 4 subunit beta-1
# AltName	AP4B1_HUMAN	Beta subunit of AP-4
# AltName	AP4B1_HUMAN	Beta4-adaptin
# BioGrid	115943	8
# CCDS	CCDS865	-. [Q9Y6B7-1]
# DISEASE	AP4B1_HUMAN	Spastic paraplegia 47, autosomal recessive (SPG47) [MIM 614066]  A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. SPG47 is characterized by neonatal hypotonia that progresses to hypertonia and spasticity, and severe mental retardation with poor or absent speech development. {ECO 0000269|PubMed 21620353}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000256658	ENSP00000256658; ENSG00000134262. [Q9Y6B7-1]
# Ensembl	ENST00000369569	ENSP00000358582; ENSG00000134262. [Q9Y6B7-1]
# ExpressionAtlas	Q9Y6B7	baseline and differential
# FUNCTION	AP4B1_HUMAN	Subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. 
# GO_component	GO:0005802	trans-Golgi network; TAS:ProtInc.
# GO_component	GO:0005905	clathrin-coated pit; IEA:UniProtKB-SubCell.
# GO_component	GO:0030131	clathrin adaptor complex; IEA:InterPro.
# GO_component	GO:0031904	endosome lumen; TAS:Reactome.
# GO_component	GO:0032588	trans-Golgi network membrane; TAS:Reactome.
# GO_function	GO:0005215	transporter activity; TAS:ProtInc.
# GO_function	GO:0008565	protein transporter activity; IEA:InterPro.
# GO_process	GO:0006886	intracellular protein transport; IEA:InterPro.
# GO_process	GO:0016192	vesicle-mediated transport; IEA:InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0016192	vesicle-mediated transport
# Gene3D	1.25.10.10	-; 1.
# Gene3D	3.30.310.10	-; 1.
# Genevisible	Q9Y6B7	HS
# HGNC	HGNC:572	AP4B1
# INTERACTION	AP4B1_HUMAN	Q9H609 ZNF576; NbExp=5; IntAct=EBI-1047606, EBI-3921014; 
# IntAct	Q9Y6B7	8
# InterPro	IPR002553	Clathrin/coatomer_adapt-like_N
# InterPro	IPR011989	ARM-like
# InterPro	IPR012295	Beta2_adaptin/TBP_C_dom
# InterPro	IPR015151	B-adaptin_app_sub_C
# InterPro	IPR016024	ARM-type_fold
# InterPro	IPR016342	AP_complex_bsu_1_2_4
# InterPro	IPR026739	AP_beta
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Disease	H01097	[Nervous system disease] Cerebral palsy
# KEGG_Pathway	ko04142	Lysosome
# MIM	607245	gene
# MIM	614066	phenotype
# Organism	AP4B1_HUMAN	Homo sapiens (Human)
# Orphanet	280763	Severe intellectual disability and progressive spastic paraplegia
# PANTHER	PTHR11134	PTHR11134
# PDB	2MJ7	NMR; -; A=610-739
# PIRSF	PIRSF002291	AP_complex_beta
# Pfam	PF01602	Adaptin_N
# Pfam	PF09066	B2-adapt-app_C
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-432720	Lysosome Vesicle Biogenesis
# Reactome	R-HSA-432722	Golgi Associated Vesicle Biogenesis
# RecName	AP4B1_HUMAN	AP-4 complex subunit beta-1
# RefSeq	NP_001240781	NM_001253852.2. [Q9Y6B7-1]
# RefSeq	NP_001240782	NM_001253853.2
# RefSeq	NP_001295241	NM_001308312.1
# RefSeq	NP_006585	NM_006594.4. [Q9Y6B7-1]
# SEQUENCE CAUTION	Sequence=BAD93054.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the adaptor complexes large subunit family. {ECO	0000305}. 
# SMART	SM01020	B2-adapt-app_C
# SUBCELLULAR LOCATION	AP4B1_HUMAN	Golgi apparatus, trans-Golgi network {ECO 0000269|PubMed 22472443}. Membrane, coated pit {ECO 0000250}. Note=Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells. 
# SUBUNIT	Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunit AP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1). Interacts with TEPSIN; this interaction requires the presence of a functional AP-4 complex. {ECO:0000269|PubMed	22472443}. 
# SUPFAM	SSF48371	SSF48371
# TISSUE SPECIFICITY	AP4B1_HUMAN	Widely expressed. 
# UCSC	uc001eeb	human. [Q9Y6B7-1]
# eggNOG	COG5096	LUCA
# eggNOG	KOG1061	Eukaryota
BLAST	swissprot:AP4B1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AP4B1_HUMAN
BioCyc	ZFISH:ENSG00000134262-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000134262-MONOMER
COXPRESdb	10717	http://coxpresdb.jp/data/gene/10717.shtml
CleanEx	HS_AP4B1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AP4B1
DIP	DIP-24209N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-24209N
DOI	10.1016/j.ajhg.2011.04.019	http://dx.doi.org/10.1016/j.ajhg.2011.04.019
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.274.11.7278	http://dx.doi.org/10.1074/jbc.274.11.7278
DOI	10.1083/jcb.201111049	http://dx.doi.org/10.1083/jcb.201111049
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB209817	http://www.ebi.ac.uk/ena/data/view/AB209817
EMBL	AF092094	http://www.ebi.ac.uk/ena/data/view/AF092094
EMBL	AK298037	http://www.ebi.ac.uk/ena/data/view/AK298037
EMBL	AL137856	http://www.ebi.ac.uk/ena/data/view/AL137856
EMBL	BC014146	http://www.ebi.ac.uk/ena/data/view/BC014146
Ensembl	ENST00000256658	http://www.ensembl.org/id/ENST00000256658
Ensembl	ENST00000369569	http://www.ensembl.org/id/ENST00000369569
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005802	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005802
GO_component	GO:0005905	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005905
GO_component	GO:0030131	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030131
GO_component	GO:0031904	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031904
GO_component	GO:0032588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032588
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0006886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006886
GO_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
Gene3D	3.30.310.10	http://www.cathdb.info/version/latest/superfamily/3.30.310.10
GeneCards	AP4B1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=AP4B1
GeneID	10717	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10717
GeneTree	ENSGT00530000063138	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063138
HGNC	HGNC:572	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:572
HOGENOM	HOG000294128	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294128&db=HOGENOM6
HOVERGEN	HBG050521	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050521&db=HOVERGEN
HPA	HPA028162	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA028162
HPA	HPA028399	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA028399
HPA	HPA028652	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA028652
InParanoid	Q9Y6B7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y6B7
IntAct	Q9Y6B7	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9Y6B7*
InterPro	IPR002553	http://www.ebi.ac.uk/interpro/entry/IPR002553
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR012295	http://www.ebi.ac.uk/interpro/entry/IPR012295
InterPro	IPR015151	http://www.ebi.ac.uk/interpro/entry/IPR015151
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
InterPro	IPR016342	http://www.ebi.ac.uk/interpro/entry/IPR016342
InterPro	IPR026739	http://www.ebi.ac.uk/interpro/entry/IPR026739
Jabion	10717	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10717
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Disease	H01097	http://www.genome.jp/dbget-bin/www_bget?H01097
KEGG_Gene	hsa:10717	http://www.genome.jp/dbget-bin/www_bget?hsa:10717
KEGG_Orthology	KO:K12401	http://www.genome.jp/dbget-bin/www_bget?KO:K12401
KEGG_Pathway	ko04142	http://www.genome.jp/kegg-bin/show_pathway?ko04142
MIM	607245	http://www.ncbi.nlm.nih.gov/omim/607245
MIM	614066	http://www.ncbi.nlm.nih.gov/omim/614066
OMA	EPGNSEM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EPGNSEM
Orphanet	280763	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=280763
OrthoDB	EOG091G058E	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G058E
PANTHER	PTHR11134	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11134
PDB	2MJ7	http://www.ebi.ac.uk/pdbe-srv/view/entry/2MJ7
PDBsum	2MJ7	http://www.ebi.ac.uk/pdbsum/2MJ7
PSORT	swissprot:AP4B1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AP4B1_HUMAN
PSORT-B	swissprot:AP4B1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AP4B1_HUMAN
PSORT2	swissprot:AP4B1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AP4B1_HUMAN
Pfam	PF01602	http://pfam.xfam.org/family/PF01602
Pfam	PF09066	http://pfam.xfam.org/family/PF09066
PharmGKB	PA24864	http://www.pharmgkb.org/do/serve?objId=PA24864&objCls=Gene
Phobius	swissprot:AP4B1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AP4B1_HUMAN
PhylomeDB	Q9Y6B7	http://phylomedb.org/?seqid=Q9Y6B7
ProteinModelPortal	Q9Y6B7	http://www.proteinmodelportal.org/query/uniprot/Q9Y6B7
PubMed	10066790	http://www.ncbi.nlm.nih.gov/pubmed/10066790
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	21620353	http://www.ncbi.nlm.nih.gov/pubmed/21620353
PubMed	22472443	http://www.ncbi.nlm.nih.gov/pubmed/22472443
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
Reactome	R-HSA-432720	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432720
Reactome	R-HSA-432722	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432722
RefSeq	NP_001240781	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001240781
RefSeq	NP_001240782	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001240782
RefSeq	NP_001295241	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001295241
RefSeq	NP_006585	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006585
SMART	SM01020	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01020
SMR	Q9Y6B7	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9Y6B7
STRING	9606.ENSP00000256658	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000256658&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
UCSC	uc001eeb	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001eeb&org=rat
UniGene	Hs.515048	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.515048
UniGene	Hs.736555	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.736555
UniProtKB	AP4B1_HUMAN	http://www.uniprot.org/uniprot/AP4B1_HUMAN
UniProtKB-AC	Q9Y6B7	http://www.uniprot.org/uniprot/Q9Y6B7
charge	swissprot:AP4B1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AP4B1_HUMAN
eggNOG	COG5096	http://eggnogapi.embl.de/nog_data/html/tree/COG5096
eggNOG	KOG1061	http://eggnogapi.embl.de/nog_data/html/tree/KOG1061
epestfind	swissprot:AP4B1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AP4B1_HUMAN
garnier	swissprot:AP4B1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AP4B1_HUMAN
helixturnhelix	swissprot:AP4B1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AP4B1_HUMAN
hmoment	swissprot:AP4B1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AP4B1_HUMAN
iep	swissprot:AP4B1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AP4B1_HUMAN
inforesidue	swissprot:AP4B1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AP4B1_HUMAN
neXtProt	NX_Q9Y6B7	http://www.nextprot.org/db/entry/NX_Q9Y6B7
octanol	swissprot:AP4B1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AP4B1_HUMAN
pepcoil	swissprot:AP4B1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AP4B1_HUMAN
pepdigest	swissprot:AP4B1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AP4B1_HUMAN
pepinfo	swissprot:AP4B1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AP4B1_HUMAN
pepnet	swissprot:AP4B1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AP4B1_HUMAN
pepstats	swissprot:AP4B1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AP4B1_HUMAN
pepwheel	swissprot:AP4B1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AP4B1_HUMAN
pepwindow	swissprot:AP4B1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AP4B1_HUMAN
sigcleave	swissprot:AP4B1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AP4B1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AT1B3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P54709-1; Sequence=Displayed; Name=2; IsoId=P54709-2; Sequence=VSP_056686, VSP_056687; Note=No experimental confirmation available.; 
# AltName	AT1B3_HUMAN	CD298
# AltName	AT1B3_HUMAN	Sodium/potassium-dependent ATPase subunit beta-3
# BioGrid	106973	102
# CCDS	CCDS3121	-. [P54709-1]
# DOMAIN	AT1B3_HUMAN	The C-terminal lobe folds into an immunoglobulin-like domain and may mediate cell adhesion properties. {ECO 0000250}. 
# Ensembl	ENST00000286371	ENSP00000286371; ENSG00000069849. [P54709-1]
# ExpressionAtlas	P54709	baseline and differential
# FUNCTION	AT1B3_HUMAN	This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known. 
# GO_component	AT1B3_HUMAN	GO 0005890 sodium potassium-exchanging ATPase complex; IDA BHF-UCL.
# GO_component	GO:0005886	plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0005901	caveola; IEA:Ensembl.
# GO_component	GO:0042470	melanosome; IEA:UniProtKB-SubCell.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	AT1B3_HUMAN	GO 0005391 sodium potassium-exchanging ATPase activity; IDA BHF-UCL.
# GO_function	GO:0001671	ATPase activator activity; IDA:BHF-UCL.
# GO_function	GO:0051117	ATPase binding; IPI:BHF-UCL.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006883	cellular sodium ion homeostasis; IDA:BHF-UCL.
# GO_process	GO:0010107	potassium ion import; IDA:BHF-UCL.
# GO_process	GO:0030007	cellular potassium ion homeostasis; IDA:BHF-UCL.
# GO_process	GO:0032781	positive regulation of ATPase activity; IDA:BHF-UCL.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0036376	sodium ion export from cell; IDA:BHF-UCL.
# GO_process	GO:0050821	protein stabilization; IDA:BHF-UCL.
# GO_process	GO:0050900	leukocyte migration; TAS:Reactome.
# GO_process	GO:0072659	protein localization to plasma membrane; IDA:BHF-UCL.
# GO_process	GO:0086009	membrane repolarization; IDA:BHF-UCL.
# GO_process	GO:1901018	positive regulation of potassium ion transmembrane transporter activity; IDA:BHF-UCL.
# GO_process	GO:1903278	positive regulation of sodium ion export from cell; IDA:BHF-UCL.
# GO_process	GO:1903288	positive regulation of potassium ion import; IDA:BHF-UCL.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0030234	enzyme regulator activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007009	plasma membrane organization
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048870	cell motility
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P54709	HS
# HGNC	HGNC:806	ATP1B3
# IntAct	P54709	5
# InterPro	IPR000402	Na/K_ATPase_sub_beta
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04090	 Cellular antigens
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko04960	Aldosterone-regulated sodium reabsorption
# KEGG_Pathway	ko04961	Endocrine and other factor-regulated calcium reabsorption
# KEGG_Pathway	ko04964	Proximal tubule bicarbonate reclamation
# KEGG_Pathway	ko04970	Salivary secretion
# KEGG_Pathway	ko04971	Gastric acid secretion
# KEGG_Pathway	ko04972	Pancreatic secretion
# KEGG_Pathway	ko04973	Carbohydrate digestion and absorption
# KEGG_Pathway	ko04974	Protein digestion and absorption
# KEGG_Pathway	ko04976	Bile secretion
# KEGG_Pathway	ko04978	Mineral absorption
# MIM	601867	gene
# Organism	AT1B3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11523	PTHR11523
# PIR	G02485	G02485
# PROSITE	PS00390	ATPASE_NA_K_BETA_1
# Pfam	PF00287	Na_K-ATPase
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-210991	Basigin interactions
# Reactome	R-HSA-5578775	Ion homeostasis
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	AT1B3_HUMAN	Sodium/potassium-transporting ATPase subunit beta-3
# RefSeq	NP_001670	NM_001679.3. [P54709-1]
# SIMILARITY	Belongs to the X(+)/potassium ATPases subunit beta family. {ECO	0000305}.
# SUBCELLULAR LOCATION	AT1B3_HUMAN	Cell membrane {ECO 0000269|PubMed 17081065}; Single-pass type II membrane protein {ECO 0000269|PubMed 17081065}. Melanosome {ECO 0000269|PubMed 17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. 
# SUBUNIT	Composed of three subunits	 alpha (catalytic), beta and gamma. 
# TCDB	3.A.3.1	the p-type atpase (p-atpase) superfamily
# TIGRFAMs	TIGR01107	Na_K_ATPase_bet
# TopDownProteomics	P54709-1	-. [P54709-1]
# UCSC	uc003eug	human. [P54709-1]
# eggNOG	ENOG411150A	LUCA
# eggNOG	KOG3927	Eukaryota
BLAST	swissprot:AT1B3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AT1B3_HUMAN
BioCyc	ZFISH:HS00972-MONOMER	http://biocyc.org/getid?id=ZFISH:HS00972-MONOMER
COXPRESdb	483	http://coxpresdb.jp/data/gene/483.shtml
CleanEx	HS_ATP1B3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP1B3
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1007/s003359900704	http://dx.doi.org/10.1007/s003359900704
DOI	10.1021/pr060363j	http://dx.doi.org/10.1021/pr060363j
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1038/nbt827	http://dx.doi.org/10.1038/nbt827
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.271.37.22754	http://dx.doi.org/10.1074/jbc.271.37.22754
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AC112504	http://www.ebi.ac.uk/ena/data/view/AC112504
EMBL	AF005890	http://www.ebi.ac.uk/ena/data/view/AF005890
EMBL	AF005891	http://www.ebi.ac.uk/ena/data/view/AF005891
EMBL	AF005892	http://www.ebi.ac.uk/ena/data/view/AF005892
EMBL	AF005893	http://www.ebi.ac.uk/ena/data/view/AF005893
EMBL	AF005894	http://www.ebi.ac.uk/ena/data/view/AF005894
EMBL	AF005895	http://www.ebi.ac.uk/ena/data/view/AF005895
EMBL	AF005896	http://www.ebi.ac.uk/ena/data/view/AF005896
EMBL	AK293697	http://www.ebi.ac.uk/ena/data/view/AK293697
EMBL	BC011835	http://www.ebi.ac.uk/ena/data/view/BC011835
EMBL	U51478	http://www.ebi.ac.uk/ena/data/view/U51478
Ensembl	ENST00000286371	http://www.ensembl.org/id/ENST00000286371
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005890
GO_component	GO:0005901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005901
GO_component	GO:0042470	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042470
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0001671	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001671
GO_function	GO:0005391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005391
GO_function	GO:0051117	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051117
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006883	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006883
GO_process	GO:0010107	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010107
GO_process	GO:0030007	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030007
GO_process	GO:0032781	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032781
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0036376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036376
GO_process	GO:0050821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050821
GO_process	GO:0050900	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050900
GO_process	GO:0072659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072659
GO_process	GO:0086009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086009
GO_process	GO:1901018	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901018
GO_process	GO:1903278	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903278
GO_process	GO:1903288	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903288
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0030234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007009
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ATP1B3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP1B3
GeneID	483	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=483
GeneTree	ENSGT00550000074530	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074530
HGNC	HGNC:806	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:806
HOGENOM	HOG000039248	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000039248&db=HOGENOM6
HOVERGEN	HBG050603	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050603&db=HOVERGEN
HPA	CAB020697	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB020697
HPA	HPA048963	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA048963
InParanoid	P54709	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P54709
IntAct	P54709	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P54709*
InterPro	IPR000402	http://www.ebi.ac.uk/interpro/entry/IPR000402
Jabion	483	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=483
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04090	http://www.genome.jp/dbget-bin/www_bget?ko04090
KEGG_Gene	hsa:483	http://www.genome.jp/dbget-bin/www_bget?hsa:483
KEGG_Orthology	KO:K01540	http://www.genome.jp/dbget-bin/www_bget?KO:K01540
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko04960	http://www.genome.jp/kegg-bin/show_pathway?ko04960
KEGG_Pathway	ko04961	http://www.genome.jp/kegg-bin/show_pathway?ko04961
KEGG_Pathway	ko04964	http://www.genome.jp/kegg-bin/show_pathway?ko04964
KEGG_Pathway	ko04970	http://www.genome.jp/kegg-bin/show_pathway?ko04970
KEGG_Pathway	ko04971	http://www.genome.jp/kegg-bin/show_pathway?ko04971
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
KEGG_Pathway	ko04973	http://www.genome.jp/kegg-bin/show_pathway?ko04973
KEGG_Pathway	ko04974	http://www.genome.jp/kegg-bin/show_pathway?ko04974
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
KEGG_Pathway	ko04978	http://www.genome.jp/kegg-bin/show_pathway?ko04978
MIM	601867	http://www.ncbi.nlm.nih.gov/omim/601867
MINT	MINT-5001083	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5001083
OMA	HQSLAEW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HQSLAEW
OrthoDB	EOG091G0DJ4	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0DJ4
PANTHER	PTHR11523	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11523
PROSITE	PS00390	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00390
PSORT	swissprot:AT1B3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AT1B3_HUMAN
PSORT-B	swissprot:AT1B3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AT1B3_HUMAN
PSORT2	swissprot:AT1B3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AT1B3_HUMAN
Pfam	PF00287	http://pfam.xfam.org/family/PF00287
PharmGKB	PA68	http://www.pharmgkb.org/do/serve?objId=PA68&objCls=Gene
Phobius	swissprot:AT1B3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AT1B3_HUMAN
PhylomeDB	P54709	http://phylomedb.org/?seqid=P54709
ProteinModelPortal	P54709	http://www.proteinmodelportal.org/query/uniprot/P54709
PubMed	12754519	http://www.ncbi.nlm.nih.gov/pubmed/12754519
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	17081065	http://www.ncbi.nlm.nih.gov/pubmed/17081065
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	8798450	http://www.ncbi.nlm.nih.gov/pubmed/8798450
PubMed	9457675	http://www.ncbi.nlm.nih.gov/pubmed/9457675
Reactome	R-HSA-210991	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-210991
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_001670	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001670
STRING	9606.ENSP00000286371	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000286371&targetmode=cogs
TCDB	3.A.3.1	http://www.tcdb.org/search/result.php?tc=3.A.3.1
TIGRFAMs	TIGR01107	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01107
UCSC	uc003eug	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003eug&org=rat
UniGene	Hs.477789	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.477789
UniProtKB	AT1B3_HUMAN	http://www.uniprot.org/uniprot/AT1B3_HUMAN
UniProtKB-AC	P54709	http://www.uniprot.org/uniprot/P54709
charge	swissprot:AT1B3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AT1B3_HUMAN
eggNOG	ENOG411150A	http://eggnogapi.embl.de/nog_data/html/tree/ENOG411150A
eggNOG	KOG3927	http://eggnogapi.embl.de/nog_data/html/tree/KOG3927
epestfind	swissprot:AT1B3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AT1B3_HUMAN
garnier	swissprot:AT1B3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AT1B3_HUMAN
helixturnhelix	swissprot:AT1B3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AT1B3_HUMAN
hmoment	swissprot:AT1B3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AT1B3_HUMAN
iep	swissprot:AT1B3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AT1B3_HUMAN
inforesidue	swissprot:AT1B3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AT1B3_HUMAN
neXtProt	NX_P54709	http://www.nextprot.org/db/entry/NX_P54709
octanol	swissprot:AT1B3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AT1B3_HUMAN
pepcoil	swissprot:AT1B3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AT1B3_HUMAN
pepdigest	swissprot:AT1B3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AT1B3_HUMAN
pepinfo	swissprot:AT1B3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AT1B3_HUMAN
pepnet	swissprot:AT1B3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AT1B3_HUMAN
pepstats	swissprot:AT1B3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AT1B3_HUMAN
pepwheel	swissprot:AT1B3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AT1B3_HUMAN
pepwindow	swissprot:AT1B3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AT1B3_HUMAN
sigcleave	swissprot:AT1B3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AT1B3_HUMAN
## Database	ID	URL or Descriptions
# AltName	S2533_HUMAN	Bone marrow stromal cell mitochondrial carrier protein
# AltName	S2533_HUMAN	Protein PNC1
# BIOPHYSICOCHEMICAL PROPERTIES	S2533_HUMAN	Kinetic parameters  KM=0.16 mM for UTP (at 25 degrees Celsius) {ECO 0000269|PubMed 25320081}; KM=0.18 mM for CTP (at 25 degrees Celsius) {ECO 0000269|PubMed 25320081}; KM=0.08 mM for TTP (at 25 degrees Celsius) {ECO 0000269|PubMed 25320081}; KM=0.30 mM for GTP (at 25 degrees Celsius) {ECO 0000269|PubMed 25320081}; Vmax=98.5 umol/min/g enzyme toward UTP (at 25 degrees Celsius) {ECO 0000269|PubMed 25320081}; Vmax=22.5 umol/min/g enzyme toward CTP (at 25 degrees Celsius) {ECO 0000269|PubMed 25320081}; Vmax=50.8 umol/min/g enzyme toward TTP (at 25 degrees Celsius) {ECO 0000269|PubMed 25320081}; Vmax=15.7 umol/min/g enzyme toward GTP (at 25 degrees Celsius) {ECO 0000269|PubMed 25320081}; Note=The inhibitory constants (Ki) of these compounds are 174 um (UTP), 195 um (CTP), 318 um (GTP), and 333 um (ITP). UTP is the best substrate. {ECO 0000269|PubMed 25320081}; 
# BioGrid	124002	3
# ChiTaRS	SLC25A33	human
# Ensembl	ENST00000302692	ENSP00000306328; ENSG00000171612
# FUNCTION	S2533_HUMAN	Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria (PubMed 25320081). Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism (PubMed 25320081). Also transports guanine but not adenine (deoxy)nucleotides (PubMed 25320081). Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10- phenanthroline, tannic acid, and mercurials (mercury dichloride, mersalyl acid, p-hydroxymercuribenzoate) (PubMed 25320081). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration (PubMed 20453889). Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production (PubMed 20453889, PubMed 17596519). Participates in dendritic cell endocytosis and may associate with mitochondrial oxidative phosphorylation (PubMed 14715278). {ECO 0000269|PubMed 14715278, ECO 0000269|PubMed 17596519, ECO 0000269|PubMed 20453889, ECO 0000269|PubMed 25320081}. 
# GO_component	GO:0005743	mitochondrial inner membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0031966	mitochondrial membrane; ISS:UniProtKB.
# GO_function	GO:0015218	pyrimidine nucleotide transmembrane transporter activity; IDA:UniProtKB.
# GO_process	GO:0000002	mitochondrial genome maintenance; IDA:UniProtKB.
# GO_process	GO:0002082	regulation of oxidative phosphorylation; IMP:UniProtKB.
# GO_process	GO:0006264	mitochondrial DNA replication; IMP:UniProtKB.
# GO_process	GO:0006390	transcription from mitochondrial promoter; IMP:UniProtKB.
# GO_process	GO:0006864	pyrimidine nucleotide transport; IDA:UniProtKB.
# GO_process	GO:0007005	mitochondrion organization; IDA:UniProtKB.
# GO_process	GO:0008284	positive regulation of cell proliferation; IMP:UniProtKB.
# GO_process	GO:0030307	positive regulation of cell growth; IMP:UniProtKB.
# GO_process	GO:0031930	mitochondria-nucleus signaling pathway; ISS:UniProtKB.
# GO_process	GO:0032869	cellular response to insulin stimulus; IDA:UniProtKB.
# GO_process	GO:0034551	mitochondrial respiratory chain complex III assembly; IMP:UniProtKB.
# GO_process	GO:0051881	regulation of mitochondrial membrane potential; IDA:UniProtKB.
# GO_process	GO:0071156	regulation of cell cycle arrest; IMP:UniProtKB.
# GO_process	GO:1903426	regulation of reactive oxygen species biosynthetic process; IMP:UniProtKB.
# GO_process	GO:1990314	cellular response to insulin-like growth factor stimulus; IDA:UniProtKB.
# GO_process	GO:1990519	mitochondrial pyrimidine nucleotide import; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006259	DNA metabolic process
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007005	mitochondrion organization
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.50.40.10	-; 1.
# Genevisible	Q9BSK2	HS
# HGNC	HGNC:29681	SLC25A33
# INDUCTION	By INS or IGF1 through the PI-3 kinase/mTOR pathway. {ECO:0000269|PubMed	17596519}. 
# IntAct	Q9BSK2	2
# InterPro	IPR018108	Mitochondrial_sb/sol_carrier
# InterPro	IPR023395	Mt_carrier_dom
# KEGG_Brite	ko02001	Solute carrier family
# MIM	610816	gene
# Organism	S2533_HUMAN	Homo sapiens (Human)
# PROSITE	PS50920	SOLCAR; 3
# Pfam	PF00153	Mito_carr; 3
# Proteomes	UP000005640	Chromosome 1
# RecName	S2533_HUMAN	Solute carrier family 25 member 33
# RefSeq	NP_115691	NM_032315.2
# SIMILARITY	Belongs to the mitochondrial carrier (TC 2.A.29) family. {ECO	0000305}. 
# SIMILARITY	Contains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule	PRU00282}.
# SUBCELLULAR LOCATION	S2533_HUMAN	Mitochondrion inner membrane {ECO 0000305|PubMed 14715278}; Multi-pass membrane protein {ECO 0000255}. 
# SUPFAM	SSF103506	SSF103506
# TCDB	2.A.29.10	the mitochondrial carrier (mc) family
# TISSUE SPECIFICITY	Expressed in the central nervous system. Also expressed in testis and skeletal muscle. Weakly expressed in heart, liver, kidney, prostate, colon and peripheral blood leukocytes. {ECO:0000269|PubMed	14715278}. 
# UCSC	uc001apw	human
# eggNOG	ENOG410XS20	LUCA
# eggNOG	KOG0757	Eukaryota
BLAST	swissprot:S2533_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S2533_HUMAN
COXPRESdb	84275	http://coxpresdb.jp/data/gene/84275.shtml
CleanEx	HS_SLC25A33	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC25A33
DOI	10.1016/j.bbrc.2003.12.071	http://dx.doi.org/10.1016/j.bbrc.2003.12.071
DOI	10.1016/j.ygeno.2006.06.016	http://dx.doi.org/10.1016/j.ygeno.2006.06.016
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/onc.2010.146	http://dx.doi.org/10.1038/onc.2010.146
DOI	10.1074/jbc.M114.610808	http://dx.doi.org/10.1074/jbc.M114.610808
DOI	10.1091/mbc.E06-12-1109	http://dx.doi.org/10.1091/mbc.E06-12-1109
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF495714	http://www.ebi.ac.uk/ena/data/view/AF495714
EMBL	AJ880283	http://www.ebi.ac.uk/ena/data/view/AJ880283
EMBL	AL928921	http://www.ebi.ac.uk/ena/data/view/AL928921
EMBL	AL928921	http://www.ebi.ac.uk/ena/data/view/AL928921
EMBL	AL954705	http://www.ebi.ac.uk/ena/data/view/AL954705
EMBL	AL954705	http://www.ebi.ac.uk/ena/data/view/AL954705
EMBL	BC004991	http://www.ebi.ac.uk/ena/data/view/BC004991
EMBL	BC073135	http://www.ebi.ac.uk/ena/data/view/BC073135
Ensembl	ENST00000302692	http://www.ensembl.org/id/ENST00000302692
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0031966	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031966
GO_function	GO:0015218	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015218
GO_process	GO:0000002	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000002
GO_process	GO:0002082	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002082
GO_process	GO:0006264	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006264
GO_process	GO:0006390	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006390
GO_process	GO:0006864	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006864
GO_process	GO:0007005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007005
GO_process	GO:0008284	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008284
GO_process	GO:0030307	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030307
GO_process	GO:0031930	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031930
GO_process	GO:0032869	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032869
GO_process	GO:0034551	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034551
GO_process	GO:0051881	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051881
GO_process	GO:0071156	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071156
GO_process	GO:1903426	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903426
GO_process	GO:1990314	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990314
GO_process	GO:1990519	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990519
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006259	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007005
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.50.40.10	http://www.cathdb.info/version/latest/superfamily/1.50.40.10
GeneCards	SLC25A33	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC25A33
GeneID	84275	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84275
GeneTree	ENSGT00550000074670	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074670
H-InvDB	HIX0009627	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0009627
HGNC	HGNC:29681	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:29681
HOGENOM	HOG000188210	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000188210&db=HOGENOM6
HOVERGEN	HBG059891	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG059891&db=HOVERGEN
HPA	HPA049982	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA049982
InParanoid	Q9BSK2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9BSK2
IntAct	Q9BSK2	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9BSK2*
InterPro	IPR018108	http://www.ebi.ac.uk/interpro/entry/IPR018108
InterPro	IPR023395	http://www.ebi.ac.uk/interpro/entry/IPR023395
Jabion	84275	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=84275
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:84275	http://www.genome.jp/dbget-bin/www_bget?hsa:84275
KEGG_Orthology	KO:K15116	http://www.genome.jp/dbget-bin/www_bget?KO:K15116
MIM	610816	http://www.ncbi.nlm.nih.gov/omim/610816
MINT	MINT-6943347	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6943347
OMA	YLLEDHA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YLLEDHA
OrthoDB	EOG091G0BCW	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0BCW
PROSITE	PS50920	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50920
PSORT	swissprot:S2533_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S2533_HUMAN
PSORT-B	swissprot:S2533_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S2533_HUMAN
PSORT2	swissprot:S2533_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S2533_HUMAN
Pfam	PF00153	http://pfam.xfam.org/family/PF00153
PharmGKB	PA162403588	http://www.pharmgkb.org/do/serve?objId=PA162403588&objCls=Gene
Phobius	swissprot:S2533_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S2533_HUMAN
PhylomeDB	Q9BSK2	http://phylomedb.org/?seqid=Q9BSK2
ProteinModelPortal	Q9BSK2	http://www.proteinmodelportal.org/query/uniprot/Q9BSK2
PubMed	14715278	http://www.ncbi.nlm.nih.gov/pubmed/14715278
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	16949250	http://www.ncbi.nlm.nih.gov/pubmed/16949250
PubMed	17596519	http://www.ncbi.nlm.nih.gov/pubmed/17596519
PubMed	20453889	http://www.ncbi.nlm.nih.gov/pubmed/20453889
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	25320081	http://www.ncbi.nlm.nih.gov/pubmed/25320081
RefSeq	NP_115691	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_115691
SMR	Q9BSK2	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9BSK2
STRING	9606.ENSP00000306328	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000306328&targetmode=cogs
SUPFAM	SSF103506	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103506
TCDB	2.A.29.10	http://www.tcdb.org/search/result.php?tc=2.A.29.10
UCSC	uc001apw	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001apw&org=rat
UniGene	Hs.568613	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.568613
UniProtKB	S2533_HUMAN	http://www.uniprot.org/uniprot/S2533_HUMAN
UniProtKB-AC	Q9BSK2	http://www.uniprot.org/uniprot/Q9BSK2
charge	swissprot:S2533_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S2533_HUMAN
eggNOG	ENOG410XS20	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS20
eggNOG	KOG0757	http://eggnogapi.embl.de/nog_data/html/tree/KOG0757
epestfind	swissprot:S2533_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S2533_HUMAN
garnier	swissprot:S2533_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S2533_HUMAN
helixturnhelix	swissprot:S2533_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S2533_HUMAN
hmoment	swissprot:S2533_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S2533_HUMAN
iep	swissprot:S2533_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S2533_HUMAN
inforesidue	swissprot:S2533_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S2533_HUMAN
neXtProt	NX_Q9BSK2	http://www.nextprot.org/db/entry/NX_Q9BSK2
octanol	swissprot:S2533_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S2533_HUMAN
pepcoil	swissprot:S2533_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S2533_HUMAN
pepdigest	swissprot:S2533_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S2533_HUMAN
pepinfo	swissprot:S2533_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S2533_HUMAN
pepnet	swissprot:S2533_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S2533_HUMAN
pepstats	swissprot:S2533_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S2533_HUMAN
pepwheel	swissprot:S2533_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S2533_HUMAN
pepwindow	swissprot:S2533_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S2533_HUMAN
sigcleave	swissprot:S2533_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S2533_HUMAN
## Database	ID	URL or Descriptions
# AltName	SO1B1_HUMAN	Liver-specific organic anion transporter 1
# AltName	SO1B1_HUMAN	OATP-C
# AltName	SO1B1_HUMAN	Sodium-independent organic anion-transporting polypeptide 2
# AltName	SO1B1_HUMAN	Solute carrier family 21 member 6
# BioGrid	115847	9
# CDD	cd06174	MFS
# ChiTaRS	SLCO1B1	human
# DISEASE	SO1B1_HUMAN	Hyperbilirubinemia, Rotor type (HBLRR) [MIM 237450]  An autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal. {ECO 0000269|PubMed 22232210}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00091	Cyclosporine
# DrugBank	DB00175	Pravastatin
# DrugBank	DB00177	Valsartan
# DrugBank	DB00213	Pantoprazole
# DrugBank	DB00220	Nelfinavir
# DrugBank	DB00224	Indinavir
# DrugBank	DB00227	Lovastatin
# DrugBank	DB00275	Olmesartan
# DrugBank	DB00279	Liothyronine
# DrugBank	DB00286	Conjugated Estrogens
# DrugBank	DB00345	Aminohippurate
# DrugBank	DB00390	Digoxin
# DrugBank	DB00412	Rosiglitazone
# DrugBank	DB00451	Levothyroxine
# DrugBank	DB00503	Ritonavir
# DrugBank	DB00509	Dextrothyroxine
# DrugBank	DB00520	Caspofungin
# DrugBank	DB00563	Methotrexate
# DrugBank	DB00583	L-Carnitine
# DrugBank	DB00641	Simvastatin
# DrugBank	DB00655	Estrone
# DrugBank	DB00661	Verapamil
# DrugBank	DB00669	Sumatriptan
# DrugBank	DB00688	Mycophenolate mofetil
# DrugBank	DB00762	Irinotecan
# DrugBank	DB00783	Estradiol
# DrugBank	DB00859	Penicillamine
# DrugBank	DB00877	Sirolimus
# DrugBank	DB00908	Quinidine
# DrugBank	DB00912	Repaglinide
# DrugBank	DB00917	Dinoprostone
# DrugBank	DB00950	Fexofenadine
# DrugBank	DB00973	Ezetimibe
# DrugBank	DB01045	Rifampicin
# DrugBank	DB01053	Benzylpenicillin
# DrugBank	DB01076	Atorvastatin
# DrugBank	DB01092	Ouabain
# DrugBank	DB01095	Fluvastatin
# DrugBank	DB01098	Rosuvastatin
# DrugBank	DB01132	Pioglitazone
# DrugBank	DB01211	Clarithromycin
# DrugBank	DB01232	Saquinavir
# DrugBank	DB01241	Gemfibrozil
# DrugBank	DB01393	Bezafibrate
# DrugBank	DB01583	Liotrix
# DrugBank	DB02659	Cholic Acid
# DrugBank	DB05239	Cobimetinib
# DrugBank	DB06151	Acetylcysteine
# DrugBank	DB06210	Eltrombopag
# DrugBank	DB06290	Simeprevir
# DrugBank	DB06403	Ambrisentan
# DrugBank	DB06589	Pazopanib
# DrugBank	DB06626	Axitinib
# DrugBank	DB06772	Cabazitaxel
# DrugBank	DB08860	Pitavastatin
# DrugBank	DB08864	Rilpivirine
# DrugBank	DB08884	Gadoxetate
# DrugBank	DB08912	Dabrafenib
# DrugBank	DB09054	Idelalisib
# DrugBank	DB09102	Daclatasvir
# DrugBank	DB09272	Eluxadoline
# DrugBank	DB09292	Sacubitril
# DrugBank	DB11362	Selexipag
# Ensembl	ENST00000256958	ENSP00000256958; ENSG00000134538
# ExpressionAtlas	Q9Y6L6	baseline and differential
# FUNCTION	SO1B1_HUMAN	Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver. {ECO 0000269|PubMed 10358072, ECO 0000269|PubMed 10601278, ECO 0000269|PubMed 12196548, ECO 0000269|PubMed 22232210}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0015125	bile acid transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015347	sodium-independent organic anion transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0015349	thyroid hormone transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0008206	bile acid metabolic process; IBA:GO_Central.
# GO_process	GO:0015711	organic anion transport; TAS:ProtInc.
# GO_process	GO:0015721	bile acid and bile salt transport; TAS:Reactome.
# GO_process	GO:0043252	sodium-independent organic anion transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0044281	small molecule metabolic process
# Genevisible	Q9Y6L6	HS
# HGNC	HGNC:10959	SLCO1B1
# InterPro	IPR002350	Kazal_dom
# InterPro	IPR004156	OA_transporter
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04976	Bile secretion
# MIM	237450	phenotype
# MIM	604843	gene
# Organism	SO1B1_HUMAN	Homo sapiens (Human)
# Orphanet	3111	Rotor syndrome
# Orphanet	413696	Statin toxicity
# PANTHER	PTHR11388	PTHR11388
# PROSITE	PS50850	MFS
# PROSITE	PS51465	KAZAL_2
# Pfam	PF03137	OATP
# Pfam	PF07648	Kazal_2
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-159418	Recycling of bile acids and salts
# Reactome	R-HSA-879518	Transport of organic anions
# RecName	SO1B1_HUMAN	Solute carrier organic anion transporter family member 1B1
# RefSeq	NP_006437	NM_006446.4
# SIMILARITY	Belongs to the organo anion transporter (TC 2.A.60) family. {ECO	0000305}. 
# SIMILARITY	Contains 1 Kazal-like domain. {ECO:0000255|PROSITE- ProRule	PRU00798}. 
# SUBCELLULAR LOCATION	SO1B1_HUMAN	Basolateral cell membrane {ECO 0000269|PubMed 12196548}; Multi-pass membrane protein {ECO 0000269|PubMed 12196548}. Note=Detected in basolateral membranes of hepatocytes. 
# SUPFAM	SSF103473	SSF103473; 3
# TCDB	2.A.60.1	the organo anion transporter (oat) family
# TIGRFAMs	TIGR00805	oat
# TISSUE SPECIFICITY	SO1B1_HUMAN	Highly expressed in liver, at the basolateral membranes of centrilobular hepatocytes. Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte. {ECO 0000269|PubMed 10358072, ECO 0000269|PubMed 10601278, ECO 0000269|PubMed 22232210}. 
# UCSC	uc001req	human
# WEB RESOURCE	SO1B1_HUMAN	Name=SeattleSNPs; URL="http //pga.gs.washington.edu/data/slco1b1/";
# eggNOG	ENOG410XRSF	LUCA
# eggNOG	KOG3626	Eukaryota
BLAST	swissprot:SO1B1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SO1B1_HUMAN
BioCyc	ZFISH:ENSG00000134538-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000134538-MONOMER
COXPRESdb	10599	http://coxpresdb.jp/data/gene/10599.shtml
CleanEx	HS_LST1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_LST1
CleanEx	HS_SLCO1B1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLCO1B1
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.274.24.17159	http://dx.doi.org/10.1074/jbc.274.24.17159
DOI	10.1074/jbc.274.52.37161	http://dx.doi.org/10.1074/jbc.274.52.37161
DOI	10.1074/jbc.M001448200	http://dx.doi.org/10.1074/jbc.M001448200
DOI	10.1074/jbc.M103792200	http://dx.doi.org/10.1074/jbc.M103792200
DOI	10.1074/jbc.M207735200	http://dx.doi.org/10.1074/jbc.M207735200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1124/jpet.302.2.804	http://dx.doi.org/10.1124/jpet.302.2.804
DOI	10.1172/JCI59526	http://dx.doi.org/10.1172/JCI59526
DOI	10.1371/journal.pone.0052563	http://dx.doi.org/10.1371/journal.pone.0052563
DrugBank	DB00091	http://www.drugbank.ca/drugs/DB00091
DrugBank	DB00175	http://www.drugbank.ca/drugs/DB00175
DrugBank	DB00177	http://www.drugbank.ca/drugs/DB00177
DrugBank	DB00213	http://www.drugbank.ca/drugs/DB00213
DrugBank	DB00220	http://www.drugbank.ca/drugs/DB00220
DrugBank	DB00224	http://www.drugbank.ca/drugs/DB00224
DrugBank	DB00227	http://www.drugbank.ca/drugs/DB00227
DrugBank	DB00275	http://www.drugbank.ca/drugs/DB00275
DrugBank	DB00279	http://www.drugbank.ca/drugs/DB00279
DrugBank	DB00286	http://www.drugbank.ca/drugs/DB00286
DrugBank	DB00345	http://www.drugbank.ca/drugs/DB00345
DrugBank	DB00390	http://www.drugbank.ca/drugs/DB00390
DrugBank	DB00412	http://www.drugbank.ca/drugs/DB00412
DrugBank	DB00451	http://www.drugbank.ca/drugs/DB00451
DrugBank	DB00503	http://www.drugbank.ca/drugs/DB00503
DrugBank	DB00509	http://www.drugbank.ca/drugs/DB00509
DrugBank	DB00520	http://www.drugbank.ca/drugs/DB00520
DrugBank	DB00563	http://www.drugbank.ca/drugs/DB00563
DrugBank	DB00583	http://www.drugbank.ca/drugs/DB00583
DrugBank	DB00641	http://www.drugbank.ca/drugs/DB00641
DrugBank	DB00655	http://www.drugbank.ca/drugs/DB00655
DrugBank	DB00661	http://www.drugbank.ca/drugs/DB00661
DrugBank	DB00669	http://www.drugbank.ca/drugs/DB00669
DrugBank	DB00688	http://www.drugbank.ca/drugs/DB00688
DrugBank	DB00762	http://www.drugbank.ca/drugs/DB00762
DrugBank	DB00783	http://www.drugbank.ca/drugs/DB00783
DrugBank	DB00859	http://www.drugbank.ca/drugs/DB00859
DrugBank	DB00877	http://www.drugbank.ca/drugs/DB00877
DrugBank	DB00908	http://www.drugbank.ca/drugs/DB00908
DrugBank	DB00912	http://www.drugbank.ca/drugs/DB00912
DrugBank	DB00917	http://www.drugbank.ca/drugs/DB00917
DrugBank	DB00950	http://www.drugbank.ca/drugs/DB00950
DrugBank	DB00973	http://www.drugbank.ca/drugs/DB00973
DrugBank	DB01045	http://www.drugbank.ca/drugs/DB01045
DrugBank	DB01053	http://www.drugbank.ca/drugs/DB01053
DrugBank	DB01076	http://www.drugbank.ca/drugs/DB01076
DrugBank	DB01092	http://www.drugbank.ca/drugs/DB01092
DrugBank	DB01095	http://www.drugbank.ca/drugs/DB01095
DrugBank	DB01098	http://www.drugbank.ca/drugs/DB01098
DrugBank	DB01132	http://www.drugbank.ca/drugs/DB01132
DrugBank	DB01211	http://www.drugbank.ca/drugs/DB01211
DrugBank	DB01232	http://www.drugbank.ca/drugs/DB01232
DrugBank	DB01241	http://www.drugbank.ca/drugs/DB01241
DrugBank	DB01393	http://www.drugbank.ca/drugs/DB01393
DrugBank	DB01583	http://www.drugbank.ca/drugs/DB01583
DrugBank	DB02659	http://www.drugbank.ca/drugs/DB02659
DrugBank	DB05239	http://www.drugbank.ca/drugs/DB05239
DrugBank	DB06151	http://www.drugbank.ca/drugs/DB06151
DrugBank	DB06210	http://www.drugbank.ca/drugs/DB06210
DrugBank	DB06290	http://www.drugbank.ca/drugs/DB06290
DrugBank	DB06403	http://www.drugbank.ca/drugs/DB06403
DrugBank	DB06589	http://www.drugbank.ca/drugs/DB06589
DrugBank	DB06626	http://www.drugbank.ca/drugs/DB06626
DrugBank	DB06772	http://www.drugbank.ca/drugs/DB06772
DrugBank	DB08860	http://www.drugbank.ca/drugs/DB08860
DrugBank	DB08864	http://www.drugbank.ca/drugs/DB08864
DrugBank	DB08884	http://www.drugbank.ca/drugs/DB08884
DrugBank	DB08912	http://www.drugbank.ca/drugs/DB08912
DrugBank	DB09054	http://www.drugbank.ca/drugs/DB09054
DrugBank	DB09102	http://www.drugbank.ca/drugs/DB09102
DrugBank	DB09272	http://www.drugbank.ca/drugs/DB09272
DrugBank	DB09292	http://www.drugbank.ca/drugs/DB09292
DrugBank	DB11362	http://www.drugbank.ca/drugs/DB11362
EMBL	AB026257	http://www.ebi.ac.uk/ena/data/view/AB026257
EMBL	AF060500	http://www.ebi.ac.uk/ena/data/view/AF060500
EMBL	AF205071	http://www.ebi.ac.uk/ena/data/view/AF205071
EMBL	AJ132573	http://www.ebi.ac.uk/ena/data/view/AJ132573
EMBL	AJ400749	http://www.ebi.ac.uk/ena/data/view/AJ400749
EMBL	AJ400750	http://www.ebi.ac.uk/ena/data/view/AJ400750
EMBL	AJ400751	http://www.ebi.ac.uk/ena/data/view/AJ400751
EMBL	AJ400752	http://www.ebi.ac.uk/ena/data/view/AJ400752
EMBL	AJ400753	http://www.ebi.ac.uk/ena/data/view/AJ400753
EMBL	AJ400754	http://www.ebi.ac.uk/ena/data/view/AJ400754
EMBL	AJ400755	http://www.ebi.ac.uk/ena/data/view/AJ400755
EMBL	AJ400756	http://www.ebi.ac.uk/ena/data/view/AJ400756
EMBL	AJ400757	http://www.ebi.ac.uk/ena/data/view/AJ400757
EMBL	AJ400758	http://www.ebi.ac.uk/ena/data/view/AJ400758
EMBL	AJ400759	http://www.ebi.ac.uk/ena/data/view/AJ400759
EMBL	AJ400760	http://www.ebi.ac.uk/ena/data/view/AJ400760
EMBL	AJ400761	http://www.ebi.ac.uk/ena/data/view/AJ400761
EMBL	AJ400762	http://www.ebi.ac.uk/ena/data/view/AJ400762
EMBL	AK312970	http://www.ebi.ac.uk/ena/data/view/AK312970
EMBL	AY945934	http://www.ebi.ac.uk/ena/data/view/AY945934
EMBL	BC114376	http://www.ebi.ac.uk/ena/data/view/BC114376
EMBL	CH471094	http://www.ebi.ac.uk/ena/data/view/CH471094
Ensembl	ENST00000256958	http://www.ensembl.org/id/ENST00000256958
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_function	GO:0015125	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015125
GO_function	GO:0015347	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015347
GO_function	GO:0015349	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015349
GO_process	GO:0008206	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008206
GO_process	GO:0015711	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015711
GO_process	GO:0015721	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015721
GO_process	GO:0043252	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043252
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GeneCards	SLCO1B1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLCO1B1
GeneID	10599	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10599
GeneTree	ENSGT00760000119014	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119014
HGNC	HGNC:10959	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10959
HOGENOM	HOG000231269	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231269&db=HOGENOM6
HOVERGEN	HBG063896	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG063896&db=HOVERGEN
HPA	HPA050892	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA050892
InParanoid	Q9Y6L6	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y6L6
InterPro	IPR002350	http://www.ebi.ac.uk/interpro/entry/IPR002350
InterPro	IPR004156	http://www.ebi.ac.uk/interpro/entry/IPR004156
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	10599	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10599
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:10599	http://www.genome.jp/dbget-bin/www_bget?hsa:10599
KEGG_Orthology	KO:K05043	http://www.genome.jp/dbget-bin/www_bget?KO:K05043
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
MIM	237450	http://www.ncbi.nlm.nih.gov/omim/237450
MIM	604843	http://www.ncbi.nlm.nih.gov/omim/604843
OMA	IIHIERR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IIHIERR
Orphanet	3111	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=3111
Orphanet	413696	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=413696
OrthoDB	EOG091G08QD	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08QD
PANTHER	PTHR11388	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11388
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PROSITE	PS51465	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51465
PSORT	swissprot:SO1B1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SO1B1_HUMAN
PSORT-B	swissprot:SO1B1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SO1B1_HUMAN
PSORT2	swissprot:SO1B1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SO1B1_HUMAN
Pfam	PF03137	http://pfam.xfam.org/family/PF03137
Pfam	PF07648	http://pfam.xfam.org/family/PF07648
PharmGKB	PA134865839	http://www.pharmgkb.org/do/serve?objId=PA134865839&objCls=Gene
Phobius	swissprot:SO1B1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SO1B1_HUMAN
PhylomeDB	Q9Y6L6	http://phylomedb.org/?seqid=Q9Y6L6
ProteinModelPortal	Q9Y6L6	http://www.proteinmodelportal.org/query/uniprot/Q9Y6L6
PubMed	10358072	http://www.ncbi.nlm.nih.gov/pubmed/10358072
PubMed	10601278	http://www.ncbi.nlm.nih.gov/pubmed/10601278
PubMed	10644574	http://www.ncbi.nlm.nih.gov/pubmed/10644574
PubMed	10779507	http://www.ncbi.nlm.nih.gov/pubmed/10779507
PubMed	11477075	http://www.ncbi.nlm.nih.gov/pubmed/11477075
PubMed	12130747	http://www.ncbi.nlm.nih.gov/pubmed/12130747
PubMed	12196548	http://www.ncbi.nlm.nih.gov/pubmed/12196548
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	22232210	http://www.ncbi.nlm.nih.gov/pubmed/22232210
PubMed	23285087	http://www.ncbi.nlm.nih.gov/pubmed/23285087
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
Reactome	R-HSA-159418	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-159418
Reactome	R-HSA-879518	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-879518
RefSeq	NP_006437	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006437
STRING	9606.ENSP00000256958	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000256958&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.60.1	http://www.tcdb.org/search/result.php?tc=2.A.60.1
TIGRFAMs	TIGR00805	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00805
UCSC	uc001req	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001req&org=rat
UniGene	Hs.449738	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.449738
UniProtKB	SO1B1_HUMAN	http://www.uniprot.org/uniprot/SO1B1_HUMAN
UniProtKB-AC	Q9Y6L6	http://www.uniprot.org/uniprot/Q9Y6L6
charge	swissprot:SO1B1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SO1B1_HUMAN
eggNOG	ENOG410XRSF	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRSF
eggNOG	KOG3626	http://eggnogapi.embl.de/nog_data/html/tree/KOG3626
epestfind	swissprot:SO1B1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SO1B1_HUMAN
garnier	swissprot:SO1B1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SO1B1_HUMAN
helixturnhelix	swissprot:SO1B1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SO1B1_HUMAN
hmoment	swissprot:SO1B1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SO1B1_HUMAN
iep	swissprot:SO1B1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SO1B1_HUMAN
inforesidue	swissprot:SO1B1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SO1B1_HUMAN
neXtProt	NX_Q9Y6L6	http://www.nextprot.org/db/entry/NX_Q9Y6L6
octanol	swissprot:SO1B1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SO1B1_HUMAN
pepcoil	swissprot:SO1B1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SO1B1_HUMAN
pepdigest	swissprot:SO1B1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SO1B1_HUMAN
pepinfo	swissprot:SO1B1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SO1B1_HUMAN
pepnet	swissprot:SO1B1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SO1B1_HUMAN
pepstats	swissprot:SO1B1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SO1B1_HUMAN
pepwheel	swissprot:SO1B1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SO1B1_HUMAN
pepwindow	swissprot:SO1B1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SO1B1_HUMAN
sigcleave	swissprot:SO1B1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SO1B1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	MAL_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=A; IsoId=P21145-1; Sequence=Displayed; Name=B; IsoId=P21145-2; Sequence=VSP_003164; Name=C; IsoId=P21145-3; Sequence=VSP_003163; Name=D; IsoId=P21145-4; Sequence=VSP_003162; 
# AltName	MAL_HUMAN	T-lymphocyte maturation-associated protein
# BioGrid	110292	9
# CCDS	CCDS2006	-. [P21145-1]
# CCDS	CCDS2007	-. [P21145-2]
# CCDS	CCDS2008	-. [P21145-3]
# CCDS	CCDS2009	-. [P21145-4]
# ChiTaRS	MAL	human
# DEVELOPMENTAL STAGE	MAL_HUMAN	Expressed in the intermediate and late stages of T-cell differentiation. 
# Ensembl	ENST00000309988	ENSP00000310880; ENSG00000172005. [P21145-1]
# Ensembl	ENST00000349807	ENSP00000322860; ENSG00000172005. [P21145-4]
# Ensembl	ENST00000353004	ENSP00000306568; ENSG00000172005. [P21145-2]
# Ensembl	ENST00000354078	ENSP00000304924; ENSG00000172005. [P21145-3]
# ExpressionAtlas	P21145	baseline and differential
# FUNCTION	MAL_HUMAN	Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function. 
# GO_component	GO:0005768	endosome; TAS:ProtInc.
# GO_component	GO:0005783	endoplasmic reticulum; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016324	apical plasma membrane; TAS:UniProtKB.
# GO_component	GO:0019898	extrinsic component of membrane; IEA:Ensembl.
# GO_component	GO:0045121	membrane raft; IDA:UniProtKB.
# GO_function	GO:0008289	lipid binding; TAS:UniProtKB.
# GO_function	GO:0015267	channel activity; TAS:ProtInc.
# GO_function	GO:0016505	peptidase activator activity involved in apoptotic process; NAS:UniProtKB.
# GO_function	GO:0019911	structural constituent of myelin sheath; IDA:UniProtKB.
# GO_process	GO:0001766	membrane raft polarization; TAS:UniProtKB.
# GO_process	GO:0006915	apoptotic process; NAS:UniProtKB.
# GO_process	GO:0007417	central nervous system development; TAS:UniProtKB.
# GO_process	GO:0030154	cell differentiation; TAS:UniProtKB.
# GO_process	GO:0042552	myelination; NAS:UniProtKB.
# GO_process	GO:0045176	apical protein localization; TAS:UniProtKB.
# GO_process	GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_function	GO:0005198	structural molecule activity
# GOslim_function	GO:0008289	lipid binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0030234	enzyme regulator activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0008219	cell death
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0061024	membrane organization
# Genevisible	P21145	HS
# HGNC	HGNC:6817	MAL
# INTERACTION	MAL_HUMAN	Q06187 BTK; NbExp=5; IntAct=EBI-3932027, EBI-624835; Q92838 EDA; NbExp=3; IntAct=EBI-3932027, EBI-529425; Q8N539 FIBCD1; NbExp=5; IntAct=EBI-3932027, EBI-10200808; P26715 KLRC1; NbExp=3; IntAct=EBI-3932027, EBI-9018187; Q5T700 LDLRAD1; NbExp=5; IntAct=EBI-3932027, EBI-10173166; Q8N8F7 LSMEM1; NbExp=3; IntAct=EBI-3932027, EBI-10200825; Q16849-3 PTPRN; NbExp=3; IntAct=EBI-3932027, EBI-10200782; Q9BZL3 SMIM3; NbExp=5; IntAct=EBI-3932027, EBI-741850; Q93009 USP7; NbExp=3; IntAct=EBI-3932027, EBI-302474; 
# IntAct	P21145	20
# InterPro	IPR008253	Marvel
# InterPro	IPR013295	MAL
# MIM	188860	gene
# Organism	MAL_HUMAN	Homo sapiens (Human)
# PIR	A29472	A29472
# PRINTS	PR01884	MALPROTEIN
# PROSITE	PS51225	MARVEL
# PTM	MAL_HUMAN	Lipoprotein. 
# Pfam	PF01284	MARVEL
# Proteomes	UP000005640	Chromosome 2
# RecName	MAL_HUMAN	Myelin and lymphocyte protein
# RefSeq	NP_002362	NM_002371.3. [P21145-1]
# RefSeq	NP_071883	NM_022438.2. [P21145-2]
# RefSeq	NP_071884	NM_022439.2. [P21145-3]
# RefSeq	NP_071885	NM_022440.2. [P21145-4]
# SIMILARITY	Belongs to the MAL family. {ECO	0000305}. 
# SIMILARITY	Contains 1 MARVEL domain. {ECO:0000255|PROSITE- ProRule	PRU00581}. 
# SUBCELLULAR LOCATION	MAL_HUMAN	Membrane; Multi-pass membrane protein. 
# UCSC	uc002stx	human. [P21145-1]
# WEB RESOURCE	MAL_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/MALID46222ch2q11.html";
# eggNOG	ENOG4111IAF	LUCA
# eggNOG	KOG4788	Eukaryota
BLAST	swissprot:MAL_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MAL_HUMAN
BioCyc	ZFISH:ENSG00000172005-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000172005-MONOMER
COXPRESdb	4118	http://coxpresdb.jp/data/gene/4118.shtml
CleanEx	HS_MAL	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_MAL
DOI	10.1006/geno.1994.1294	http://dx.doi.org/10.1006/geno.1994.1294
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.84.7.1997	http://dx.doi.org/10.1073/pnas.84.7.1997
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC103563	http://www.ebi.ac.uk/ena/data/view/AC103563
EMBL	AK311844	http://www.ebi.ac.uk/ena/data/view/AK311844
EMBL	BC000458	http://www.ebi.ac.uk/ena/data/view/BC000458
EMBL	BC003006	http://www.ebi.ac.uk/ena/data/view/BC003006
EMBL	CH471219	http://www.ebi.ac.uk/ena/data/view/CH471219
EMBL	CR541879	http://www.ebi.ac.uk/ena/data/view/CR541879
EMBL	M15800	http://www.ebi.ac.uk/ena/data/view/M15800
EMBL	X76220	http://www.ebi.ac.uk/ena/data/view/X76220
EMBL	X76221	http://www.ebi.ac.uk/ena/data/view/X76221
EMBL	X76222	http://www.ebi.ac.uk/ena/data/view/X76222
EMBL	X76223	http://www.ebi.ac.uk/ena/data/view/X76223
EMBL	X76678	http://www.ebi.ac.uk/ena/data/view/X76678
EMBL	X76679	http://www.ebi.ac.uk/ena/data/view/X76679
EMBL	X76680	http://www.ebi.ac.uk/ena/data/view/X76680
EMBL	X76681	http://www.ebi.ac.uk/ena/data/view/X76681
Ensembl	ENST00000309988	http://www.ensembl.org/id/ENST00000309988
Ensembl	ENST00000349807	http://www.ensembl.org/id/ENST00000349807
Ensembl	ENST00000353004	http://www.ensembl.org/id/ENST00000353004
Ensembl	ENST00000354078	http://www.ensembl.org/id/ENST00000354078
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0019898	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019898
GO_component	GO:0045121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045121
GO_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GO_function	GO:0015267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015267
GO_function	GO:0016505	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016505
GO_function	GO:0019911	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019911
GO_process	GO:0001766	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001766
GO_process	GO:0006915	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006915
GO_process	GO:0007417	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007417
GO_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GO_process	GO:0042552	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042552
GO_process	GO:0045176	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045176
GO_process	GO:1902043	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902043
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_function	GO:0005198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198
GOslim_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0030234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0008219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
GeneCards	MAL	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=MAL
GeneID	4118	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4118
GeneTree	ENSGT00730000110762	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00730000110762
H-InvDB	HIX0117680	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0117680
H-InvDB	HIX0117687	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0117687
HGNC	HGNC:6817	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6817
HOGENOM	HOG000231752	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231752&db=HOGENOM6
HOVERGEN	HBG000925	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000925&db=HOVERGEN
HPA	HPA065691	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA065691
InParanoid	P21145	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21145
IntAct	P21145	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21145*
InterPro	IPR008253	http://www.ebi.ac.uk/interpro/entry/IPR008253
InterPro	IPR013295	http://www.ebi.ac.uk/interpro/entry/IPR013295
Jabion	4118	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=4118
KEGG_Gene	hsa:4118	http://www.genome.jp/dbget-bin/www_bget?hsa:4118
MIM	188860	http://www.ncbi.nlm.nih.gov/omim/188860
OMA	VPIPLIQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VPIPLIQ
OrthoDB	EOG091G0OS1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0OS1
PRINTS	PR01884	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01884
PROSITE	PS51225	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51225
PSORT	swissprot:MAL_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MAL_HUMAN
PSORT-B	swissprot:MAL_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MAL_HUMAN
PSORT2	swissprot:MAL_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MAL_HUMAN
Pfam	PF01284	http://pfam.xfam.org/family/PF01284
PharmGKB	PA30565	http://www.pharmgkb.org/do/serve?objId=PA30565&objCls=Gene
Phobius	swissprot:MAL_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MAL_HUMAN
PhylomeDB	P21145	http://phylomedb.org/?seqid=P21145
ProteinModelPortal	P21145	http://www.proteinmodelportal.org/query/uniprot/P21145
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	3494249	http://www.ncbi.nlm.nih.gov/pubmed/3494249
PubMed	8088843	http://www.ncbi.nlm.nih.gov/pubmed/8088843
PubMed	8132541	http://www.ncbi.nlm.nih.gov/pubmed/8132541
RefSeq	NP_002362	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002362
RefSeq	NP_071883	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_071883
RefSeq	NP_071884	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_071884
RefSeq	NP_071885	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_071885
STRING	9606.ENSP00000310880	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000310880&targetmode=cogs
UCSC	uc002stx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002stx&org=rat
UniGene	Hs.80395	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.80395
UniProtKB	MAL_HUMAN	http://www.uniprot.org/uniprot/MAL_HUMAN
UniProtKB-AC	P21145	http://www.uniprot.org/uniprot/P21145
charge	swissprot:MAL_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MAL_HUMAN
eggNOG	ENOG4111IAF	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111IAF
eggNOG	KOG4788	http://eggnogapi.embl.de/nog_data/html/tree/KOG4788
epestfind	swissprot:MAL_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MAL_HUMAN
garnier	swissprot:MAL_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MAL_HUMAN
helixturnhelix	swissprot:MAL_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MAL_HUMAN
hmoment	swissprot:MAL_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MAL_HUMAN
iep	swissprot:MAL_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MAL_HUMAN
inforesidue	swissprot:MAL_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MAL_HUMAN
neXtProt	NX_P21145	http://www.nextprot.org/db/entry/NX_P21145
octanol	swissprot:MAL_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MAL_HUMAN
pepcoil	swissprot:MAL_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MAL_HUMAN
pepdigest	swissprot:MAL_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MAL_HUMAN
pepinfo	swissprot:MAL_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MAL_HUMAN
pepnet	swissprot:MAL_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MAL_HUMAN
pepstats	swissprot:MAL_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MAL_HUMAN
pepwheel	swissprot:MAL_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MAL_HUMAN
pepwindow	swissprot:MAL_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MAL_HUMAN
sigcleave	swissprot:MAL_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MAL_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S6A15_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9H2J7-1; Sequence=Displayed; Name=2; IsoId=Q9H2J7-2; Sequence=VSP_043030, VSP_043031; Note=No experimental confirmation available.; Name=3; IsoId=Q9H2J7-3; Sequence=VSP_045192; Note=No experimental confirmation available.; 
# AltName	S6A15_HUMAN	Sodium- and chloride-dependent neurotransmitter transporter NTT73
# AltName	S6A15_HUMAN	Sodium-coupled branched-chain amino-acid transporter 1
# AltName	S6A15_HUMAN	Solute carrier family 6 member 15
# AltName	S6A15_HUMAN	Transporter v7-3
# BIOPHYSICOCHEMICAL PROPERTIES	S6A15_HUMAN	Kinetic parameters  KM=0.16 mM for L-leucine (at pH 7.5, 100 mM NaCL, -70 mV) {ECO 0000269|PubMed 16226721}; KM=0.16 mM for L-valine (at pH 7.5, 100 mM NaCL, -70 mV)) {ECO 0000269|PubMed 16226721}; KM=0.08 mM for L-isoleucine (at pH 7.5, 100 mM NaCL, -70 mV) {ECO 0000269|PubMed 16226721}; KM=0.11 mM for L-methionine (at pH 7.5, 100 mM NaCL, -70 mV) {ECO 0000269|PubMed 16226721}; KM=0.38 mM for L-proline (at pH 7.5, 100 mM NaCL, -70 mV) {ECO 0000269|PubMed 16226721}; pH dependence  Optimum pH is 7.5-8.5. Strongly inhibited at acidic PH. {ECO 0000269|PubMed 16226721}; 
# BioGrid	120426	27
# CCDS	CCDS53816	-. [Q9H2J7-3]
# CCDS	CCDS9026	-. [Q9H2J7-1]
# CCDS	CCDS9027	-. [Q9H2J7-2]
# ChiTaRS	SLC6A15	human
# Ensembl	ENST00000266682	ENSP00000266682; ENSG00000072041. [Q9H2J7-1]
# Ensembl	ENST00000450363	ENSP00000390706; ENSG00000072041. [Q9H2J7-2]
# Ensembl	ENST00000552192	ENSP00000450145; ENSG00000072041. [Q9H2J7-3]
# ExpressionAtlas	Q9H2J7	baseline and differential
# FUNCTION	S6A15_HUMAN	Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1 1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent. {ECO 0000269|PubMed 16226721}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_function	GO:0005326	neurotransmitter transporter activity; NAS:UniProtKB.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; TAS:Reactome.
# GO_function	S6A15_HUMAN	GO 0005298 proline sodium symporter activity; IBA GO_Central.
# GO_function	S6A15_HUMAN	GO 0005328 neurotransmitter sodium symporter activity; IEA InterPro.
# GO_process	GO:0006836	neurotransmitter transport; NAS:UniProtKB.
# GO_process	GO:0006865	amino acid transport; TAS:Reactome.
# GO_process	GO:0015804	neutral amino acid transport; IDA:UniProtKB.
# GO_process	GO:0015820	leucine transport; ISS:UniProtKB.
# GO_process	GO:0015824	proline transport; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q9H2J7	HS
# HGNC	HGNC:13621	SLC6A15
# IntAct	Q9H2J7	2
# InterPro	IPR000175	Na/ntran_symport
# InterPro	IPR002438	Na/ntran_symport_orphan
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Brite	ko04040	 Ion channels
# MIM	607971	gene
# Organism	S6A15_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11616	PTHR11616; 2
# PRINTS	PR00176	NANEUSMPORT
# PRINTS	PR01206	ORPHTRNSPORT
# PROSITE	PS00610	NA_NEUROTRAN_SYMP_1
# PROSITE	PS00754	NA_NEUROTRAN_SYMP_2
# PROSITE	PS50267	NA_NEUROTRAN_SYMP_3
# Pfam	PF00209	SNF
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-352230	Amino acid transport across the plasma membrane
# Reactome	R-HSA-442660	Na+/Cl- dependent neurotransmitter transporters
# RecName	S6A15_HUMAN	Sodium-dependent neutral amino acid transporter B(0)AT2
# RefSeq	NP_001139807	NM_001146335.2. [Q9H2J7-3]
# RefSeq	NP_060527	NM_018057.6. [Q9H2J7-2]
# RefSeq	NP_877499	NM_182767.5. [Q9H2J7-1]
# SIMILARITY	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A15 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	S6A15_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	2.A.22.6:the neurotransmitter	sodium symporter (nss) family
# TISSUE SPECIFICITY	Almost exclusively expressed in the brain. {ECO:0000269|PubMed	16226721}. 
# UCSC	uc001szv	human. [Q9H2J7-1]
# eggNOG	COG0733	LUCA
# eggNOG	KOG3659	Eukaryota
BLAST	swissprot:S6A15_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S6A15_HUMAN
BioCyc	ZFISH:ENSG00000072041-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000072041-MONOMER
COXPRESdb	55117	http://coxpresdb.jp/data/gene/55117.shtml
CleanEx	HS_SLC6A15	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC6A15
DOI	10.1006/geno.2000.6387	http://dx.doi.org/10.1006/geno.2000.6387
DOI	10.1016/j.bbrc.2005.09.128	http://dx.doi.org/10.1016/j.bbrc.2005.09.128
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AC018922	http://www.ebi.ac.uk/ena/data/view/AC018922
EMBL	AC128657	http://www.ebi.ac.uk/ena/data/view/AC128657
EMBL	AF265577	http://www.ebi.ac.uk/ena/data/view/AF265577
EMBL	AK022853	http://www.ebi.ac.uk/ena/data/view/AK022853
EMBL	AK291207	http://www.ebi.ac.uk/ena/data/view/AK291207
EMBL	AK294945	http://www.ebi.ac.uk/ena/data/view/AK294945
EMBL	BC070040	http://www.ebi.ac.uk/ena/data/view/BC070040
EMBL	CH471054	http://www.ebi.ac.uk/ena/data/view/CH471054
Ensembl	ENST00000266682	http://www.ensembl.org/id/ENST00000266682
Ensembl	ENST00000450363	http://www.ensembl.org/id/ENST00000450363
Ensembl	ENST00000552192	http://www.ensembl.org/id/ENST00000552192
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005298	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005298
GO_function	GO:0005326	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005326
GO_function	GO:0005328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005328
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_process	GO:0006836	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006836
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GO_process	GO:0015804	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015804
GO_process	GO:0015820	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015820
GO_process	GO:0015824	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015824
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC6A15	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC6A15
GeneID	55117	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55117
GeneTree	ENSGT00760000119044	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119044
HGNC	HGNC:13621	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13621
HOGENOM	HOG000116406	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116406&db=HOGENOM6
HOVERGEN	HBG071421	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG071421&db=HOVERGEN
HPA	HPA008609	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA008609
InParanoid	Q9H2J7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9H2J7
IntAct	Q9H2J7	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9H2J7*
InterPro	IPR000175	http://www.ebi.ac.uk/interpro/entry/IPR000175
InterPro	IPR002438	http://www.ebi.ac.uk/interpro/entry/IPR002438
Jabion	55117	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55117
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:55117	http://www.genome.jp/dbget-bin/www_bget?hsa:55117
KEGG_Orthology	KO:K05048	http://www.genome.jp/dbget-bin/www_bget?KO:K05048
MIM	607971	http://www.ncbi.nlm.nih.gov/omim/607971
OMA	AWVVVCL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AWVVVCL
OrthoDB	EOG091G08PX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08PX
PANTHER	PTHR11616	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11616
PRINTS	PR00176	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00176
PRINTS	PR01206	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01206
PROSITE	PS00610	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00610
PROSITE	PS00754	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00754
PROSITE	PS50267	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50267
PSORT	swissprot:S6A15_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S6A15_HUMAN
PSORT-B	swissprot:S6A15_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S6A15_HUMAN
PSORT2	swissprot:S6A15_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S6A15_HUMAN
Pfam	PF00209	http://pfam.xfam.org/family/PF00209
PharmGKB	PA37799	http://www.pharmgkb.org/do/serve?objId=PA37799&objCls=Gene
Phobius	swissprot:S6A15_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S6A15_HUMAN
PhylomeDB	Q9H2J7	http://phylomedb.org/?seqid=Q9H2J7
ProteinModelPortal	Q9H2J7	http://www.proteinmodelportal.org/query/uniprot/Q9H2J7
PubMed	11112352	http://www.ncbi.nlm.nih.gov/pubmed/11112352
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16226721	http://www.ncbi.nlm.nih.gov/pubmed/16226721
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
Reactome	R-HSA-352230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-352230
Reactome	R-HSA-442660	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442660
RefSeq	NP_001139807	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001139807
RefSeq	NP_060527	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060527
RefSeq	NP_877499	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_877499
STRING	9606.ENSP00000266682	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000266682&targetmode=cogs
TCDB	2.A.22.6	http://www.tcdb.org/search/result.php?tc=2.A.22.6
UCSC	uc001szv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001szv&org=rat
UniGene	Hs.44424	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.44424
UniGene	Hs.680104	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.680104
UniProtKB	S6A15_HUMAN	http://www.uniprot.org/uniprot/S6A15_HUMAN
UniProtKB-AC	Q9H2J7	http://www.uniprot.org/uniprot/Q9H2J7
charge	swissprot:S6A15_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S6A15_HUMAN
eggNOG	COG0733	http://eggnogapi.embl.de/nog_data/html/tree/COG0733
eggNOG	KOG3659	http://eggnogapi.embl.de/nog_data/html/tree/KOG3659
epestfind	swissprot:S6A15_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S6A15_HUMAN
garnier	swissprot:S6A15_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S6A15_HUMAN
helixturnhelix	swissprot:S6A15_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S6A15_HUMAN
hmoment	swissprot:S6A15_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S6A15_HUMAN
iep	swissprot:S6A15_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S6A15_HUMAN
inforesidue	swissprot:S6A15_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S6A15_HUMAN
neXtProt	NX_Q9H2J7	http://www.nextprot.org/db/entry/NX_Q9H2J7
octanol	swissprot:S6A15_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S6A15_HUMAN
pepcoil	swissprot:S6A15_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S6A15_HUMAN
pepdigest	swissprot:S6A15_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S6A15_HUMAN
pepinfo	swissprot:S6A15_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S6A15_HUMAN
pepnet	swissprot:S6A15_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S6A15_HUMAN
pepstats	swissprot:S6A15_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S6A15_HUMAN
pepwheel	swissprot:S6A15_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S6A15_HUMAN
pepwindow	swissprot:S6A15_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S6A15_HUMAN
sigcleave	swissprot:S6A15_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S6A15_HUMAN
## Database	ID	URL or Descriptions
# AltName	XCT_HUMAN	Amino acid transport system xc-
# AltName	XCT_HUMAN	Calcium channel blocker resistance protein CCBR1
# AltName	XCT_HUMAN	Solute carrier family 7 member 11
# AltName	XCT_HUMAN	xCT
# BioGrid	117179	2
# DrugBank	DB00138	L-Cystine
# DrugBank	DB00740	Riluzole
# DrugBank	DB00795	Sulfasalazine
# DrugBank	DB01098	Rosuvastatin
# DrugBank	DB06151	Acetylcysteine
# DrugBank	DB08834	Tauroursodeoxycholic acid
# Ensembl	ENST00000280612	ENSP00000280612; ENSG00000151012
# ExpressionAtlas	Q9UPY5	baseline and differential
# FUNCTION	XCT_HUMAN	Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate. {ECO 0000269|PubMed 15151999}. 
# GO_component	GO:0005791	rough endoplasmic reticulum; IEA:Ensembl.
# GO_component	GO:0005856	cytoskeleton; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0009986	cell surface; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_function	XCT_HUMAN	GO 0015327 cystine glutamate antiporter activity; TAS ProtInc.
# GO_process	GO:0006865	amino acid transport; TAS:Reactome.
# GO_process	GO:0006979	response to oxidative stress; IEA:Ensembl.
# GO_process	GO:0007420	brain development; IEA:Ensembl.
# GO_process	GO:0009636	response to toxic substance; IDA:UniProtKB.
# GO_process	GO:0035094	response to nicotine; IEA:Ensembl.
# GO_process	GO:0050900	leukocyte migration; TAS:Reactome.
# GO_process	GO:0070306	lens fiber cell differentiation; IEA:Ensembl.
# GO_process	GO:0070527	platelet aggregation; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005856	cytoskeleton
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007155	cell adhesion
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0048870	cell motility
# Genevisible	Q9UPY5	HS
# HGNC	HGNC:11059	SLC7A11
# INTERACTION	XCT_HUMAN	P16070 CD44; NbExp=4; IntAct=EBI-3843348, EBI-490245; 
# IntAct	Q9UPY5	5
# InterPro	IPR002293	AA/rel_permease1
# InterPro	IPR004760	L_AA_transporter
# KEGG_Brite	ko02001	Solute carrier family
# MIM	607933	gene
# Organism	XCT_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11785	PTHR11785
# PIRSF	PIRSF006060	AA_transporter
# Pfam	PF13520	AA_permease_2
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-210991	Basigin interactions
# Reactome	R-HSA-352230	Amino acid transport across the plasma membrane
# RecName	XCT_HUMAN	Cystine/glutamate transporter
# RefSeq	NP_055146	NM_014331.3
# SIMILARITY	Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	XCT_HUMAN	Membrane {ECO 0000269|PubMed 15151999}; Multi-pass membrane protein {ECO 0000269|PubMed 15151999}. 
# SUBUNIT	Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc. {ECO	0000250}. 
# TCDB	2.A.3.8.18	the amino acid-polyamine-organocation (apc) family
# TIGRFAMs	TIGR00911	2A0308
# UCSC	uc062zqn	human
# eggNOG	COG0531	LUCA
# eggNOG	KOG1287	Eukaryota
BLAST	swissprot:XCT_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:XCT_HUMAN
BioCyc	MetaCyc:ENSG00000151012-MONOMER	http://biocyc.org/getid?id=MetaCyc:ENSG00000151012-MONOMER
BioCyc	ZFISH:ENSG00000151012-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000151012-MONOMER
COXPRESdb	23657	http://coxpresdb.jp/data/gene/23657.shtml
CleanEx	HS_SLC7A11	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC7A11
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M402428200	http://dx.doi.org/10.1074/jbc.M402428200
DOI	10.1074/mcp.M800588-MCP200	http://dx.doi.org/10.1074/mcp.M800588-MCP200
DOI	10.1089/ars.2000.2.4-665	http://dx.doi.org/10.1089/ars.2000.2.4-665
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00138	http://www.drugbank.ca/drugs/DB00138
DrugBank	DB00740	http://www.drugbank.ca/drugs/DB00740
DrugBank	DB00795	http://www.drugbank.ca/drugs/DB00795
DrugBank	DB01098	http://www.drugbank.ca/drugs/DB01098
DrugBank	DB06151	http://www.drugbank.ca/drugs/DB06151
DrugBank	DB08834	http://www.drugbank.ca/drugs/DB08834
EMBL	AB026891	http://www.ebi.ac.uk/ena/data/view/AB026891
EMBL	AF200708	http://www.ebi.ac.uk/ena/data/view/AF200708
EMBL	AF252872	http://www.ebi.ac.uk/ena/data/view/AF252872
EMBL	AJ277882	http://www.ebi.ac.uk/ena/data/view/AJ277882
EMBL	AK290359	http://www.ebi.ac.uk/ena/data/view/AK290359
EMBL	AK314855	http://www.ebi.ac.uk/ena/data/view/AK314855
EMBL	BC012087	http://www.ebi.ac.uk/ena/data/view/BC012087
EMBL	CH471056	http://www.ebi.ac.uk/ena/data/view/CH471056
Ensembl	ENST00000280612	http://www.ensembl.org/id/ENST00000280612
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005791	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005791
GO_component	GO:0005856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015327	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015327
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GO_process	GO:0006979	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979
GO_process	GO:0007420	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007420
GO_process	GO:0009636	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009636
GO_process	GO:0035094	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035094
GO_process	GO:0050900	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050900
GO_process	GO:0070306	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070306
GO_process	GO:0070527	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070527
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GeneCards	SLC7A11	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC7A11
GeneID	23657	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23657
GeneTree	ENSGT00760000119037	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119037
HGNC	HGNC:11059	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11059
HOGENOM	HOG000098892	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000098892&db=HOGENOM6
HOVERGEN	HBG000476	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000476&db=HOVERGEN
InParanoid	Q9UPY5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UPY5
IntAct	Q9UPY5	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9UPY5*
InterPro	IPR002293	http://www.ebi.ac.uk/interpro/entry/IPR002293
InterPro	IPR004760	http://www.ebi.ac.uk/interpro/entry/IPR004760
Jabion	23657	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=23657
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:23657	http://www.genome.jp/dbget-bin/www_bget?hsa:23657
KEGG_Orthology	KO:K13869	http://www.genome.jp/dbget-bin/www_bget?KO:K13869
MIM	607933	http://www.ncbi.nlm.nih.gov/omim/607933
OMA	MHRPFKX	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MHRPFKX
OrthoDB	EOG091G07EM	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07EM
PANTHER	PTHR11785	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785
PSORT	swissprot:XCT_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:XCT_HUMAN
PSORT-B	swissprot:XCT_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:XCT_HUMAN
PSORT2	swissprot:XCT_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:XCT_HUMAN
Pfam	PF13520	http://pfam.xfam.org/family/PF13520
PharmGKB	PA35919	http://www.pharmgkb.org/do/serve?objId=PA35919&objCls=Gene
Phobius	swissprot:XCT_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:XCT_HUMAN
PhylomeDB	Q9UPY5	http://phylomedb.org/?seqid=Q9UPY5
ProteinModelPortal	Q9UPY5	http://www.proteinmodelportal.org/query/uniprot/Q9UPY5
PubMed	11133847	http://www.ncbi.nlm.nih.gov/pubmed/11133847
PubMed	11213471	http://www.ncbi.nlm.nih.gov/pubmed/11213471
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15151999	http://www.ncbi.nlm.nih.gov/pubmed/15151999
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	19369195	http://www.ncbi.nlm.nih.gov/pubmed/19369195
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
Reactome	R-HSA-210991	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-210991
Reactome	R-HSA-352230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-352230
RefSeq	NP_055146	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055146
STRING	9606.ENSP00000280612	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000280612&targetmode=cogs
TCDB	2.A.3.8.18	http://www.tcdb.org/search/result.php?tc=2.A.3.8.18
TIGRFAMs	TIGR00911	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00911
UCSC	uc062zqn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc062zqn&org=rat
UniGene	Hs.390594	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.390594
UniProtKB	XCT_HUMAN	http://www.uniprot.org/uniprot/XCT_HUMAN
UniProtKB-AC	Q9UPY5	http://www.uniprot.org/uniprot/Q9UPY5
charge	swissprot:XCT_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:XCT_HUMAN
eggNOG	COG0531	http://eggnogapi.embl.de/nog_data/html/tree/COG0531
eggNOG	KOG1287	http://eggnogapi.embl.de/nog_data/html/tree/KOG1287
epestfind	swissprot:XCT_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:XCT_HUMAN
garnier	swissprot:XCT_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:XCT_HUMAN
helixturnhelix	swissprot:XCT_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:XCT_HUMAN
hmoment	swissprot:XCT_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:XCT_HUMAN
iep	swissprot:XCT_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:XCT_HUMAN
inforesidue	swissprot:XCT_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:XCT_HUMAN
neXtProt	NX_Q9UPY5	http://www.nextprot.org/db/entry/NX_Q9UPY5
octanol	swissprot:XCT_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:XCT_HUMAN
pepcoil	swissprot:XCT_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:XCT_HUMAN
pepdigest	swissprot:XCT_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:XCT_HUMAN
pepinfo	swissprot:XCT_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:XCT_HUMAN
pepnet	swissprot:XCT_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:XCT_HUMAN
pepstats	swissprot:XCT_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:XCT_HUMAN
pepwheel	swissprot:XCT_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:XCT_HUMAN
pepwindow	swissprot:XCT_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:XCT_HUMAN
sigcleave	swissprot:XCT_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:XCT_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	PCYOX_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UHG3-1; Sequence=Displayed; Name=2; IsoId=Q9UHG3-2; Sequence=VSP_056701; Note=No experimental confirmation available.; 
# AltName	PCYOX_HUMAN	Prenylcysteine lyase
# BRENDA	1.8.3	2681
# BioGrid	119547	16
# CATALYTIC ACTIVITY	PCYOX_HUMAN	An S-prenyl-L-cysteine + O(2) + H(2)O = a prenal + L-cysteine + H(2)O(2). 
# CAUTION	Was originally thought to be a lyase and was therefore termed prenylcysteine lyase. {ECO:0000305|PubMed	10585463}. 
# CCDS	CCDS1902	-. [Q9UHG3-1]
# COFACTOR	Name=FAD; Xref=ChEBI:CHEBI	57692; 
# ChiTaRS	PCYOX1	human
# Ensembl	ENST00000433351	ENSP00000387654; ENSG00000116005. [Q9UHG3-1]
# ExpressionAtlas	Q9UHG3	baseline and differential
# FUNCTION	PCYOX_HUMAN	Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine. 
# GO_component	GO:0005764	lysosome; IDA:BHF-UCL.
# GO_component	GO:0005774	vacuolar membrane; IBA:GO_Central.
# GO_component	GO:0005886	plasma membrane; IEA:Ensembl.
# GO_component	GO:0034361	very-low-density lipoprotein particle; IDA:BHF-UCL.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0001735	prenylcysteine oxidase activity; IDA:BHF-UCL.
# GO_function	GO:0008555	chloride-transporting ATPase activity; IEA:Ensembl.
# GO_process	GO:0030327	prenylated protein catabolic process; NAS:UniProtKB.
# GO_process	GO:0030328	prenylcysteine catabolic process; IBA:GO_Central.
# GO_process	GO:0030329	prenylcysteine metabolic process; NAS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005764	lysosome
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006520	cellular amino acid metabolic process
# GOslim_process	GO:0006790	sulfur compound metabolic process
# GOslim_process	GO:0009056	catabolic process
# Gene3D	3.50.50.60	-; 2.
# Genevisible	Q9UHG3	HS
# HGNC	HGNC:20588	PCYOX1
# IntAct	Q9UHG3	4
# InterPro	IPR010795	Prenylcys_lyase
# InterPro	IPR017046	Prenylcysteine_Oxase
# InterPro	IPR023753	FAD/NAD-binding_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00900	Terpenoid backbone biosynthesis
# MIM	610995	gene
# Organism	PCYOX_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR15944	PTHR15944
# PIRSF	PIRSF036292	Prenylcysteine_oxidase
# PTM	PCYOX_HUMAN	The protein is glycosylated at one or more potential N- glycosylation sites. {ECO 0000269|PubMed 16335952, ECO 0000269|PubMed 19159218}. 
# Pfam	PF07156	Prenylcys_lyase
# Proteomes	UP000005640	Chromosome 2
# RecName	PCYOX_HUMAN	Prenylcysteine oxidase 1
# RefSeq	NP_057381	NM_016297.3. [Q9UHG3-1]
# SEQUENCE CAUTION	Sequence=BAA74931.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the prenylcysteine oxidase family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	PCYOX_HUMAN	Lysosome. 
# SUPFAM	SSF51905	SSF51905
# TISSUE SPECIFICITY	PCYOX_HUMAN	Ubiquitous. 
# TopDownProteomics	Q9UHG3-1	-. [Q9UHG3-1]
# UCSC	uc002sgn	human. [Q9UHG3-1]
# eggNOG	ENOG410IE2Q	Eukaryota
# eggNOG	ENOG410Y3UN	LUCA
BLAST	swissprot:PCYOX_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:PCYOX_HUMAN
BioCyc	ZFISH:HS03967-MONOMER	http://biocyc.org/getid?id=ZFISH:HS03967-MONOMER
COXPRESdb	51449	http://coxpresdb.jp/data/gene/51449.shtml
CleanEx	HS_PCYOX1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_PCYOX1
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr0502065	http://dx.doi.org/10.1021/pr0502065
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.274.50.35802	http://dx.doi.org/10.1074/jbc.274.50.35802
DOI	10.1093/dnares/5.6.355	http://dx.doi.org/10.1093/dnares/5.6.355
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EC_number	EC:1.8.3.5	http://www.genome.jp/dbget-bin/www_bget?EC:1.8.3.5
EMBL	AB020715	http://www.ebi.ac.uk/ena/data/view/AB020715
EMBL	AC016700	http://www.ebi.ac.uk/ena/data/view/AC016700
EMBL	AC079338	http://www.ebi.ac.uk/ena/data/view/AC079338
EMBL	AF181490	http://www.ebi.ac.uk/ena/data/view/AF181490
EMBL	AK314453	http://www.ebi.ac.uk/ena/data/view/AK314453
EMBL	AK316013	http://www.ebi.ac.uk/ena/data/view/AK316013
EMBL	AY359063	http://www.ebi.ac.uk/ena/data/view/AY359063
EMBL	BC007029	http://www.ebi.ac.uk/ena/data/view/BC007029
EMBL	BC033815	http://www.ebi.ac.uk/ena/data/view/BC033815
EMBL	BC051891	http://www.ebi.ac.uk/ena/data/view/BC051891
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
ENZYME	1.8.3.5	http://enzyme.expasy.org/EC/1.8.3.5
Ensembl	ENST00000433351	http://www.ensembl.org/id/ENST00000433351
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GO_component	GO:0005774	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005774
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0034361	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034361
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0001735	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001735
GO_function	GO:0008555	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008555
GO_process	GO:0030327	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030327
GO_process	GO:0030328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030328
GO_process	GO:0030329	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030329
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520
GOslim_process	GO:0006790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790
GOslim_process	GO:0009056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056
Gene3D	3.50.50.60	http://www.cathdb.info/version/latest/superfamily/3.50.50.60
GeneCards	PCYOX1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=PCYOX1
GeneID	51449	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51449
GeneTree	ENSGT00390000011206	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000011206
HGNC	HGNC:20588	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20588
HOGENOM	HOG000241149	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000241149&db=HOGENOM6
HOVERGEN	HBG053532	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053532&db=HOVERGEN
HPA	HPA035193	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035193
InParanoid	Q9UHG3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UHG3
IntAct	Q9UHG3	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9UHG3*
IntEnz	1.8.3.5	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.8.3.5
InterPro	IPR010795	http://www.ebi.ac.uk/interpro/entry/IPR010795
InterPro	IPR017046	http://www.ebi.ac.uk/interpro/entry/IPR017046
InterPro	IPR023753	http://www.ebi.ac.uk/interpro/entry/IPR023753
Jabion	51449	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=51449
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:51449	http://www.genome.jp/dbget-bin/www_bget?hsa:51449
KEGG_Orthology	KO:K05906	http://www.genome.jp/dbget-bin/www_bget?KO:K05906
KEGG_Pathway	ko00900	http://www.genome.jp/kegg-bin/show_pathway?ko00900
KEGG_Reaction	rn:R09562	http://www.genome.jp/dbget-bin/www_bget?rn:R09562
MIM	610995	http://www.ncbi.nlm.nih.gov/omim/610995
OMA	NGIECAA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NGIECAA
OrthoDB	EOG091G0A3Q	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0A3Q
PANTHER	PTHR15944	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15944
PSORT	swissprot:PCYOX_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:PCYOX_HUMAN
PSORT-B	swissprot:PCYOX_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:PCYOX_HUMAN
PSORT2	swissprot:PCYOX_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:PCYOX_HUMAN
Pfam	PF07156	http://pfam.xfam.org/family/PF07156
PharmGKB	PA134959852	http://www.pharmgkb.org/do/serve?objId=PA134959852&objCls=Gene
Phobius	swissprot:PCYOX_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:PCYOX_HUMAN
PhylomeDB	Q9UHG3	http://phylomedb.org/?seqid=Q9UHG3
ProteinModelPortal	Q9UHG3	http://www.proteinmodelportal.org/query/uniprot/Q9UHG3
PubMed	10048485	http://www.ncbi.nlm.nih.gov/pubmed/10048485
PubMed	10585463	http://www.ncbi.nlm.nih.gov/pubmed/10585463
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	16335952	http://www.ncbi.nlm.nih.gov/pubmed/16335952
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
RefSeq	NP_057381	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_057381
STRING	9606.ENSP00000387654	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000387654&targetmode=cogs
SUPFAM	SSF51905	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905
UCSC	uc002sgn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002sgn&org=rat
UniGene	Hs.567502	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.567502
UniProtKB	PCYOX_HUMAN	http://www.uniprot.org/uniprot/PCYOX_HUMAN
UniProtKB-AC	Q9UHG3	http://www.uniprot.org/uniprot/Q9UHG3
charge	swissprot:PCYOX_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:PCYOX_HUMAN
eggNOG	ENOG410IE2Q	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IE2Q
eggNOG	ENOG410Y3UN	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y3UN
epestfind	swissprot:PCYOX_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:PCYOX_HUMAN
garnier	swissprot:PCYOX_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:PCYOX_HUMAN
helixturnhelix	swissprot:PCYOX_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:PCYOX_HUMAN
hmoment	swissprot:PCYOX_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:PCYOX_HUMAN
iep	swissprot:PCYOX_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:PCYOX_HUMAN
inforesidue	swissprot:PCYOX_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:PCYOX_HUMAN
neXtProt	NX_Q9UHG3	http://www.nextprot.org/db/entry/NX_Q9UHG3
octanol	swissprot:PCYOX_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:PCYOX_HUMAN
pepcoil	swissprot:PCYOX_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:PCYOX_HUMAN
pepdigest	swissprot:PCYOX_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:PCYOX_HUMAN
pepinfo	swissprot:PCYOX_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:PCYOX_HUMAN
pepnet	swissprot:PCYOX_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:PCYOX_HUMAN
pepstats	swissprot:PCYOX_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:PCYOX_HUMAN
pepwheel	swissprot:PCYOX_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:PCYOX_HUMAN
pepwindow	swissprot:PCYOX_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:PCYOX_HUMAN
sigcleave	swissprot:PCYOX_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:PCYOX_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AQ12B_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A6NM10-1; Sequence=Displayed; Name=2; IsoId=A6NM10-2; Sequence=VSP_032800; Note=No experimental confirmation available.; 
# CCDS	CCDS46560	-. [A6NM10-2]
# DOMAIN	AQ12B_HUMAN	Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). 
# Ensembl	ENST00000407834	ENSP00000384894; ENSG00000185176. [A6NM10-2]
# Ensembl	ENST00000621682	ENSP00000481577; ENSG00000185176. [A6NM10-1]
# ExpressionAtlas	A6NM10	baseline and differential
# FUNCTION	AQ12B_HUMAN	Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015250	water channel activity; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# Gene3D	1.20.1080.10	-; 1.
# Genevisible	A6NM10	HS
# HGNC	HGNC:6096	AQP12B
# InterPro	IPR000425	MIP
# InterPro	IPR016697	Aquaporin_11/12
# InterPro	IPR023265	Aquaporin_12
# InterPro	IPR023271	Aquaporin-like
# KEGG_Brite	ko04040	Ion channels
# Organism	AQ12B_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR21191:SF8	PTHR21191:SF8
# PIRSF	PIRSF017529	Aquaporin_11/12
# PRINTS	PR00783	MINTRINSICP
# PRINTS	PR02025	AQUAPORIN12
# Pfam	PF00230	MIP
# Proteomes	UP000005640	Chromosome 2
# RecName	AQ12B_HUMAN	Aquaporin-12B
# RefSeq	NP_001095937	NM_001102467.1. [A6NM10-2]
# SIMILARITY	Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	AQ12B_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF81338	SSF81338
# UCSC	uc010fzj	human. [A6NM10-1]
# eggNOG	ENOG410IJA3	Eukaryota
# eggNOG	ENOG4111GCP	LUCA
BLAST	swissprot:AQ12B_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AQ12B_HUMAN
BioCyc	ZFISH:G66-30760-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-30760-MONOMER
COXPRESdb	653437	http://coxpresdb.jp/data/gene/653437.shtml
CleanEx	HS_AQP12B	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AQP12B
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC011298	http://www.ebi.ac.uk/ena/data/view/AC011298
EMBL	BC139748	http://www.ebi.ac.uk/ena/data/view/BC139748
Ensembl	ENST00000407834	http://www.ensembl.org/id/ENST00000407834
Ensembl	ENST00000621682	http://www.ensembl.org/id/ENST00000621682
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015250	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015250
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
Gene3D	1.20.1080.10	http://www.cathdb.info/version/latest/superfamily/1.20.1080.10
GeneCards	AQP12B	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=AQP12B
GeneID	653437	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=653437
GeneTree	ENSGT00530000063816	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063816
HGNC	HGNC:6096	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6096
HOGENOM	HOG000034023	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000034023&db=HOGENOM6
HOVERGEN	HBG050557	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050557&db=HOVERGEN
HPA	HPA042216	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042216
InParanoid	A6NM10	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=A6NM10
InterPro	IPR000425	http://www.ebi.ac.uk/interpro/entry/IPR000425
InterPro	IPR016697	http://www.ebi.ac.uk/interpro/entry/IPR016697
InterPro	IPR023265	http://www.ebi.ac.uk/interpro/entry/IPR023265
InterPro	IPR023271	http://www.ebi.ac.uk/interpro/entry/IPR023271
Jabion	653437	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=653437
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:653437	http://www.genome.jp/dbget-bin/www_bget?hsa:653437
KEGG_Orthology	KO:K09871	http://www.genome.jp/dbget-bin/www_bget?KO:K09871
OMA	DMHMIKN	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DMHMIKN
OrthoDB	EOG091G0JBQ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0JBQ
PANTHER	PTHR21191:SF8	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21191:SF8
PRINTS	PR00783	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00783
PRINTS	PR02025	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR02025
PSORT	swissprot:AQ12B_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AQ12B_HUMAN
PSORT-B	swissprot:AQ12B_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AQ12B_HUMAN
PSORT2	swissprot:AQ12B_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AQ12B_HUMAN
Pfam	PF00230	http://pfam.xfam.org/family/PF00230
PharmGKB	PA29902	http://www.pharmgkb.org/do/serve?objId=PA29902&objCls=Gene
Phobius	swissprot:AQ12B_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AQ12B_HUMAN
PhylomeDB	A6NM10	http://phylomedb.org/?seqid=A6NM10
ProteinModelPortal	A6NM10	http://www.proteinmodelportal.org/query/uniprot/A6NM10
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
RefSeq	NP_001095937	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001095937
STRING	9606.ENSP00000337144	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000337144&targetmode=cogs
SUPFAM	SSF81338	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81338
UCSC	uc010fzj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010fzj&org=rat
UniGene	Hs.437167	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.437167
UniProtKB	AQ12B_HUMAN	http://www.uniprot.org/uniprot/AQ12B_HUMAN
UniProtKB-AC	A6NM10	http://www.uniprot.org/uniprot/A6NM10
charge	swissprot:AQ12B_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AQ12B_HUMAN
eggNOG	ENOG410IJA3	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IJA3
eggNOG	ENOG4111GCP	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111GCP
epestfind	swissprot:AQ12B_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AQ12B_HUMAN
garnier	swissprot:AQ12B_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AQ12B_HUMAN
helixturnhelix	swissprot:AQ12B_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AQ12B_HUMAN
hmoment	swissprot:AQ12B_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AQ12B_HUMAN
iep	swissprot:AQ12B_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AQ12B_HUMAN
inforesidue	swissprot:AQ12B_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AQ12B_HUMAN
neXtProt	NX_A6NM10	http://www.nextprot.org/db/entry/NX_A6NM10
octanol	swissprot:AQ12B_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AQ12B_HUMAN
pepcoil	swissprot:AQ12B_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AQ12B_HUMAN
pepdigest	swissprot:AQ12B_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AQ12B_HUMAN
pepinfo	swissprot:AQ12B_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AQ12B_HUMAN
pepnet	swissprot:AQ12B_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AQ12B_HUMAN
pepstats	swissprot:AQ12B_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AQ12B_HUMAN
pepwheel	swissprot:AQ12B_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AQ12B_HUMAN
pepwindow	swissprot:AQ12B_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AQ12B_HUMAN
sigcleave	swissprot:AQ12B_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AQ12B_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SCN1B_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Beta-1; IsoId=Q07699-1; Sequence=Displayed; Name=2; Synonyms=Beta-1B, beta1A, beta1B; IsoId=Q07699-2; Sequence=VSP_041982; Note=Due to intron 3 retention.; 
# BioGrid	112229	2
# CCDS	CCDS12441	-. [Q07699-1]
# CCDS	CCDS46047	-. [Q07699-2]
# DISEASE	SCN1B_HUMAN	Atrial fibrillation, familial, 13 (ATFB13) [MIM 615377]  A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. {ECO 0000269|PubMed 19808477}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCN1B_HUMAN	Brugada syndrome 5 (BRGDA5) [MIM 612838]  A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset. {ECO 0000269|PubMed 18464934}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCN1B_HUMAN	Generalized epilepsy with febrile seizures plus 1 (GEFS+1) [MIM 604233]  A rare autosomal dominant, familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. This disease combines febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity. {ECO 0000269|PubMed 17928445, ECO 0000269|PubMed 21040232, ECO 0000269|PubMed 9697698}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00313	Valproic Acid
# DrugBank	DB00909	Zonisamide
# Ensembl	ENST00000262631	ENSP00000262631; ENSG00000105711. [Q07699-1]
# Ensembl	ENST00000415950	ENSP00000396915; ENSG00000105711. [Q07699-2]
# ExpressionAtlas	Q07699	baseline and differential
# FUNCTION	SCN1B_HUMAN	Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. {ECO 0000269|PubMed 14622265}. 
# FUNCTION	SCN1B_HUMAN	Isoform 2  Cell adhesion molecule that plays a critical role in neuronal migration and pathfinding during brain development. Stimulates neurite outgrowth. {ECO 0000269|PubMed 14622265}. 
# GO_component	GO:0001518	voltage-gated sodium channel complex; IDA:BHF-UCL.
# GO_component	GO:0005576	extracellular region; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0014704	intercalated disc; ISS:BHF-UCL.
# GO_component	GO:0030315	T-tubule; ISS:BHF-UCL.
# GO_component	GO:0033268	node of Ranvier; ISS:BHF-UCL.
# GO_function	GO:0005248	voltage-gated sodium channel activity; IDA:BHF-UCL.
# GO_function	GO:0017080	sodium channel regulator activity; IDA:BHF-UCL.
# GO_function	GO:0019871	sodium channel inhibitor activity; ISS:BHF-UCL.
# GO_function	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential; IMP:BHF-UCL.
# GO_function	GO:0086062	voltage-gated sodium channel activity involved in Purkinje myocyte action potential; IMP:BHF-UCL.
# GO_process	GO:0007155	cell adhesion; IEA:UniProtKB-KW.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:ProtInc.
# GO_process	GO:0007411	axon guidance; ISS:BHF-UCL.
# GO_process	GO:0010765	positive regulation of sodium ion transport; IDA:BHF-UCL.
# GO_process	GO:0010976	positive regulation of neuron projection development; ISS:BHF-UCL.
# GO_process	GO:0019227	neuronal action potential propagation; ISS:BHF-UCL.
# GO_process	GO:0021966	corticospinal neuron axon guidance; ISS:BHF-UCL.
# GO_process	GO:0035725	sodium ion transmembrane transport; IDA:BHF-UCL.
# GO_process	GO:0040011	locomotion; ISS:BHF-UCL.
# GO_process	GO:0046684	response to pyrethroid; IEA:Ensembl.
# GO_process	GO:0051899	membrane depolarization; IDA:BHF-UCL.
# GO_process	GO:0060048	cardiac muscle contraction; IMP:BHF-UCL.
# GO_process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization; ISS:BHF-UCL.
# GO_process	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization; IMP:BHF-UCL.
# GO_process	GO:0061337	cardiac conduction; ISS:BHF-UCL.
# GO_process	GO:0086002	cardiac muscle cell action potential involved in contraction; IMP:BHF-UCL.
# GO_process	GO:0086012	membrane depolarization during cardiac muscle cell action potential; ISS:BHF-UCL.
# GO_process	GO:0086047	membrane depolarization during Purkinje myocyte cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086091	regulation of heart rate by cardiac conduction; IMP:BHF-UCL.
# GO_process	GO:2000649	regulation of sodium ion transmembrane transporter activity; IDA:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005576	extracellular region
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0007155	cell adhesion
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0040011	locomotion
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.40.10	-; 1.
# Genevisible	Q07699	HS
# HGNC	HGNC:10586	SCN1B
# InterPro	IPR007110	Ig-like_dom
# InterPro	IPR013106	Ig_V-set
# InterPro	IPR013783	Ig-like_fold
# InterPro	IPR027098	Na_channel_b1/b3
# KEGG_Brite	ko04040	Ion channels
# KEGG_Disease	H00728	[Cardiovascular disease] Brugada syndrome (BRS)
# KEGG_Disease	H00783	[Nervous system disease; Epilepsy] Dravet syndrome/ Severe myoclonic epilepsy in infancy (SMEI)
# MIM	600235	gene
# MIM	604233	phenotype
# MIM	612838	phenotype
# MIM	615377	phenotype
# Organism	SCN1B_HUMAN	Homo sapiens (Human)
# Orphanet	130	Brugada syndrome
# Orphanet	33069	Dravet syndrome
# Orphanet	36387	Generalized epilepsy with febrile seizures-plus
# Orphanet	871	Familial progressive cardiac conduction defect
# PANTHER	PTHR10546	PTHR10546
# PIR	A55734	A55734
# Pfam	PF07686	V-set
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-445095	Interaction between L1 and Ankyrins
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# RecName	SCN1B_HUMAN	Sodium channel subunit beta-1
# RefSeq	NP_001028	NM_001037.4. [Q07699-1]
# RefSeq	NP_001308534	NM_001321605.1
# RefSeq	NP_950238	NM_199037.4. [Q07699-2]
# SIMILARITY	Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family. {ECO	0000305}. 
# SIMILARITY	Contains 1 Ig-like C2-type (immunoglobulin-like) domain. {ECO	0000305}.
# SUBCELLULAR LOCATION	SCN1B_HUMAN	Isoform 1  Cell membrane {ECO 0000269|PubMed 17928445, ECO 0000305|PubMed 8125980}; Single- pass type I membrane protein {ECO 0000255, ECO 0000305|PubMed 8125980}. 
# SUBCELLULAR LOCATION	SCN1B_HUMAN	Isoform 2  Secreted {ECO 0000269|PubMed 21994374}. 
# SUBUNIT	SCN1B_HUMAN	The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2 and beta-3. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 is covalently linked by disulfide bonds. Beta-1 or beta-3 subunits associate with neurofascin. Associates with SCN10A (By similarity). Interacts with SCN1A (PubMed 15525788, PubMed 17928445). Interacts with SCN8A (PubMed 26900580). {ECO 0000250|UniProtKB Q00954, ECO 0000269|PubMed 15525788, ECO 0000269|PubMed 17928445, ECO 0000269|PubMed 26900580}. 
# SUPFAM	SSF48726	SSF48726
# TISSUE SPECIFICITY	The overall expression of isoforms 1 and 2 is very similar. Isoform 1 is abundantly expressed in skeletal muscle, heart and brain. Isoform 2 is highly expressed in brain and skeletal muscle and present at a very low level in heart, placenta, lung, liver, kidney and pancreas. In brain, isoform 2 is most abundant in the cerebellum, followed by the cerebral cortex and occipital lobe, while isoform 1 levels are higher in the cortex compared to the cerebellum. Isoform 2 is expressed in many regions of the brain, including cerebellar Purkinje cells, cortex pyramidal neurons and many of the neuronal fibers throughout the brain (at protein level). Also detected in dorsal root ganglion, in fibers of the spinal nerve and in cortical neurons and their processes (at protein level). {ECO:0000269|PubMed	14622265}. 
# UCSC	uc002nxo	human. [Q07699-1]
# eggNOG	ENOG410IVI4	Eukaryota
# eggNOG	ENOG4111MS0	LUCA
BLAST	swissprot:SCN1B_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SCN1B_HUMAN
COXPRESdb	6324	http://coxpresdb.jp/data/gene/6324.shtml
CleanEx	HS_SCN1B	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SCN1B
DOI	10.1002/acn3.276	http://dx.doi.org/10.1002/acn3.276
DOI	10.1006/geno.1994.1551	http://dx.doi.org/10.1006/geno.1994.1551
DOI	10.1038/1252	http://dx.doi.org/10.1038/1252
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1046/j.1432-1033.2003.03878.x	http://dx.doi.org/10.1046/j.1432-1033.2003.03878.x
DOI	10.1093/hmg/2.6.745	http://dx.doi.org/10.1093/hmg/2.6.745
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1399-0004.2009.01155.x	http://dx.doi.org/10.1111/j.1399-0004.2009.01155.x
DOI	10.1111/j.1468-1331.2010.03216.x	http://dx.doi.org/10.1111/j.1468-1331.2010.03216.x
DOI	10.1161/CIRCEP.108.779181	http://dx.doi.org/10.1161/CIRCEP.108.779181
DOI	10.1172/JCI33891	http://dx.doi.org/10.1172/JCI33891
DOI	10.1523/JNEUROSCI.0361-11.2011	http://dx.doi.org/10.1523/JNEUROSCI.0361-11.2011
DOI	10.1523/JNEUROSCI.2034-04.2004	http://dx.doi.org/10.1523/JNEUROSCI.2034-04.2004
DOI	10.1523/JNEUROSCI.3515-07.2007	http://dx.doi.org/10.1523/JNEUROSCI.3515-07.2007
DrugBank	DB00313	http://www.drugbank.ca/drugs/DB00313
DrugBank	DB00909	http://www.drugbank.ca/drugs/DB00909
EMBL	AC020907	http://www.ebi.ac.uk/ena/data/view/AC020907
EMBL	AK313279	http://www.ebi.ac.uk/ena/data/view/AK313279
EMBL	AY391842	http://www.ebi.ac.uk/ena/data/view/AY391842
EMBL	BC067122	http://www.ebi.ac.uk/ena/data/view/BC067122
EMBL	BT019923	http://www.ebi.ac.uk/ena/data/view/BT019923
EMBL	DQ677665	http://www.ebi.ac.uk/ena/data/view/DQ677665
EMBL	L10338	http://www.ebi.ac.uk/ena/data/view/L10338
EMBL	L16242	http://www.ebi.ac.uk/ena/data/view/L16242
EMBL	U12189	http://www.ebi.ac.uk/ena/data/view/U12189
EMBL	U12190	http://www.ebi.ac.uk/ena/data/view/U12190
EMBL	U12191	http://www.ebi.ac.uk/ena/data/view/U12191
EMBL	U12192	http://www.ebi.ac.uk/ena/data/view/U12192
EMBL	U12193	http://www.ebi.ac.uk/ena/data/view/U12193
Ensembl	ENST00000262631	http://www.ensembl.org/id/ENST00000262631
Ensembl	ENST00000415950	http://www.ensembl.org/id/ENST00000415950
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0001518	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001518
GO_component	GO:0005576	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0014704	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014704
GO_component	GO:0030315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030315
GO_component	GO:0033268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033268
GO_function	GO:0005248	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005248
GO_function	GO:0017080	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017080
GO_function	GO:0019871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019871
GO_function	GO:0086006	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086006
GO_function	GO:0086062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086062
GO_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007411	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007411
GO_process	GO:0010765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010765
GO_process	GO:0010976	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010976
GO_process	GO:0019227	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019227
GO_process	GO:0021966	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021966
GO_process	GO:0035725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035725
GO_process	GO:0040011	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011
GO_process	GO:0046684	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046684
GO_process	GO:0051899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051899
GO_process	GO:0060048	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060048
GO_process	GO:0060307	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060307
GO_process	GO:0060371	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060371
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:0086002	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086002
GO_process	GO:0086012	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086012
GO_process	GO:0086047	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086047
GO_process	GO:0086091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086091
GO_process	GO:2000649	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000649
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005576	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0040011	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.40.10	http://www.cathdb.info/version/latest/superfamily/2.60.40.10
GeneCards	SCN1B	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SCN1B
GeneID	6324	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6324
GeneTree	ENSGT00390000018560	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000018560
HGNC	HGNC:10586	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10586
HOGENOM	HOG000276881	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276881&db=HOGENOM6
HOVERGEN	HBG056582	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG056582&db=HOVERGEN
HPA	CAB032824	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB032824
InParanoid	Q07699	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q07699
InterPro	IPR007110	http://www.ebi.ac.uk/interpro/entry/IPR007110
InterPro	IPR013106	http://www.ebi.ac.uk/interpro/entry/IPR013106
InterPro	IPR013783	http://www.ebi.ac.uk/interpro/entry/IPR013783
InterPro	IPR027098	http://www.ebi.ac.uk/interpro/entry/IPR027098
Jabion	6324	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6324
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00728	http://www.genome.jp/dbget-bin/www_bget?H00728
KEGG_Disease	H00783	http://www.genome.jp/dbget-bin/www_bget?H00783
KEGG_Gene	hsa:6324	http://www.genome.jp/dbget-bin/www_bget?hsa:6324
KEGG_Orthology	KO:K04845	http://www.genome.jp/dbget-bin/www_bget?KO:K04845
MIM	600235	http://www.ncbi.nlm.nih.gov/omim/600235
MIM	604233	http://www.ncbi.nlm.nih.gov/omim/604233
MIM	612838	http://www.ncbi.nlm.nih.gov/omim/612838
MIM	615377	http://www.ncbi.nlm.nih.gov/omim/615377
OMA	ISCKKRS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ISCKKRS
Orphanet	130	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=130
Orphanet	33069	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=33069
Orphanet	36387	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=36387
Orphanet	871	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=871
OrthoDB	EOG091G0OF7	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0OF7
PANTHER	PTHR10546	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10546
PSORT	swissprot:SCN1B_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SCN1B_HUMAN
PSORT-B	swissprot:SCN1B_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SCN1B_HUMAN
PSORT2	swissprot:SCN1B_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SCN1B_HUMAN
Pfam	PF07686	http://pfam.xfam.org/family/PF07686
PharmGKB	PA302	http://www.pharmgkb.org/do/serve?objId=PA302&objCls=Gene
Phobius	swissprot:SCN1B_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SCN1B_HUMAN
PhylomeDB	Q07699	http://phylomedb.org/?seqid=Q07699
ProteinModelPortal	Q07699	http://www.proteinmodelportal.org/query/uniprot/Q07699
PubMed	14622265	http://www.ncbi.nlm.nih.gov/pubmed/14622265
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15525788	http://www.ncbi.nlm.nih.gov/pubmed/15525788
PubMed	17928445	http://www.ncbi.nlm.nih.gov/pubmed/17928445
PubMed	18464934	http://www.ncbi.nlm.nih.gov/pubmed/18464934
PubMed	19522081	http://www.ncbi.nlm.nih.gov/pubmed/19522081
PubMed	19808477	http://www.ncbi.nlm.nih.gov/pubmed/19808477
PubMed	21040232	http://www.ncbi.nlm.nih.gov/pubmed/21040232
PubMed	21994374	http://www.ncbi.nlm.nih.gov/pubmed/21994374
PubMed	26900580	http://www.ncbi.nlm.nih.gov/pubmed/26900580
PubMed	7851891	http://www.ncbi.nlm.nih.gov/pubmed/7851891
PubMed	8125980	http://www.ncbi.nlm.nih.gov/pubmed/8125980
PubMed	8394762	http://www.ncbi.nlm.nih.gov/pubmed/8394762
PubMed	9697698	http://www.ncbi.nlm.nih.gov/pubmed/9697698
Reactome	R-HSA-445095	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-445095
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
RefSeq	NP_001028	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001028
RefSeq	NP_001308534	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001308534
RefSeq	NP_950238	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_950238
SMR	Q07699	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q07699
STRING	9606.ENSP00000396915	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000396915&targetmode=cogs
SUPFAM	SSF48726	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48726
UCSC	uc002nxo	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002nxo&org=rat
UniGene	Hs.436646	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.436646
UniProtKB	SCN1B_HUMAN	http://www.uniprot.org/uniprot/SCN1B_HUMAN
UniProtKB-AC	Q07699	http://www.uniprot.org/uniprot/Q07699
charge	swissprot:SCN1B_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SCN1B_HUMAN
eggNOG	ENOG410IVI4	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IVI4
eggNOG	ENOG4111MS0	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111MS0
epestfind	swissprot:SCN1B_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SCN1B_HUMAN
garnier	swissprot:SCN1B_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SCN1B_HUMAN
helixturnhelix	swissprot:SCN1B_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SCN1B_HUMAN
hmoment	swissprot:SCN1B_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SCN1B_HUMAN
iep	swissprot:SCN1B_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SCN1B_HUMAN
inforesidue	swissprot:SCN1B_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SCN1B_HUMAN
neXtProt	NX_Q07699	http://www.nextprot.org/db/entry/NX_Q07699
octanol	swissprot:SCN1B_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SCN1B_HUMAN
pepcoil	swissprot:SCN1B_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SCN1B_HUMAN
pepdigest	swissprot:SCN1B_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SCN1B_HUMAN
pepinfo	swissprot:SCN1B_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SCN1B_HUMAN
pepnet	swissprot:SCN1B_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SCN1B_HUMAN
pepstats	swissprot:SCN1B_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SCN1B_HUMAN
pepwheel	swissprot:SCN1B_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SCN1B_HUMAN
pepwindow	swissprot:SCN1B_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SCN1B_HUMAN
sigcleave	swissprot:SCN1B_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SCN1B_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TRPM3_HUMAN	Event=Alternative splicing; Named isoforms=11; Name=1; Synonyms=TRPM3f; IsoId=Q9HCF6-1; Sequence=Displayed; Name=2; Synonyms=TRPM3a; IsoId=Q9HCF6-2; Sequence=VSP_012826; Name=3; Synonyms=TRPM3b; IsoId=Q9HCF6-3; Sequence=VSP_012826, VSP_012828; Name=4; Synonyms=TRPM3d; IsoId=Q9HCF6-4; Sequence=VSP_012826, VSP_012829; Name=5; Synonyms=TRPM3e; IsoId=Q9HCF6-5; Sequence=VSP_012826, VSP_012828, VSP_012829; Name=6; Synonyms=TRPM3c; IsoId=Q9HCF6-6; Sequence=VSP_012826, VSP_012830; Name=7; IsoId=Q9HCF6-7; Sequence=VSP_012829; Name=8; IsoId=Q9HCF6-8; Sequence=VSP_012826, VSP_012827, VSP_012829; Name=10; IsoId=Q9HCF6-10; Sequence=VSP_012826, VSP_012831, VSP_012832; Name=11; IsoId=Q9HCF6-11; Sequence=VSP_039107; Name=12; IsoId=Q9HCF6-12; Sequence=VSP_043515, VSP_012826, VSP_043516; Note=No experimental confirmation available.; 
# AltName	TRPM3_HUMAN	Long transient receptor potential channel 3
# AltName	TRPM3_HUMAN	Melastatin-2
# BioGrid	123085	5
# CCDS	CCDS43835	-. [Q9HCF6-2]
# CCDS	CCDS6637	-. [Q9HCF6-12]
# ChiTaRS	TRPM3	human
# Ensembl	ENST00000361823	ENSP00000355395; ENSG00000083067. [Q9HCF6-12]
# Ensembl	ENST00000377110	ENSP00000366314; ENSG00000083067. [Q9HCF6-2]
# Ensembl	ENST00000377111	ENSP00000366315; ENSG00000083067. [Q9HCF6-10]
# ExpressionAtlas	Q9HCF6	baseline and differential
# FUNCTION	TRPM3_HUMAN	Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation. {ECO 0000269|PubMed 12672799, ECO 0000269|PubMed 12672827}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005227	calcium activated cation channel activity; IEA:InterPro.
# GO_function	GO:0005261	cation channel activity; IDA:MGI.
# GO_function	GO:0005262	calcium channel activity; TAS:Reactome.
# GO_process	GO:0006812	cation transport; IDA:MGI.
# GO_process	GO:0016048	detection of temperature stimulus; IEA:InterPro.
# GO_process	GO:0050951	sensory perception of temperature stimulus; IEA:InterPro.
# GO_process	GO:0051262	protein tetramerization; IEA:InterPro.
# GO_process	GO:0070588	calcium ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9HCF6	HS
# HGNC	HGNC:17992	TRPM3
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR029583	TRPM3
# InterPro	IPR032415	TRPM_tetra
# KEGG_Brite	ko04040	Ion channels
# MIM	608961	gene
# Organism	TRPM3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR13800:SF7	PTHR13800:SF7; 3
# Pfam	PF00520	Ion_trans
# Pfam	PF16519	TRPM_tetra
# Proteomes	UP000005640	Chromosome 9
# Reactome	R-HSA-3295583	TRP channels
# RecName	TRPM3_HUMAN	Transient receptor potential cation channel subfamily M member 3
# RefSeq	NP_001007472	NM_001007471.2. [Q9HCF6-2]
# RefSeq	NP_996831	NM_206948.2. [Q9HCF6-12]
# RefSeq	XP_011517340	XM_011519038.2. [Q9HCF6-1]
# RefSeq	XP_011517341	XM_011519039.2. [Q9HCF6-7]
# RefSeq	XP_011517343	XM_011519041.2. [Q9HCF6-3]
# RefSeq	XP_011517346	XM_011519044.2. [Q9HCF6-5]
# RefSeq	XP_011517348	XM_011519046.2. [Q9HCF6-4]
# RefSeq	XP_011517349	XM_011519047.2. [Q9HCF6-10]
# RefSeq	XP_016870631	XM_017015142.1. [Q9HCF6-11]
# SEQUENCE CAUTION	TRPM3_HUMAN	Sequence=CAB66480.2; Type=Miscellaneous discrepancy; Note=Cloning artifact in C-terminus.; Evidence={ECO 0000305}; Sequence=CAM13096.1; Type=Erroneous gene model prediction; Evidence={ECO 0000305}; Sequence=CAM13169.1; Type=Erroneous gene model prediction; Evidence={ECO 0000305}; Sequence=CAM15782.1; Type=Erroneous gene model prediction; Evidence={ECO 0000305}; Sequence=CAM17596.1; Type=Erroneous gene model prediction; Evidence={ECO 0000305}; Sequence=CAM22746.1; Type=Erroneous gene model prediction; Evidence={ECO 0000305};
# SIMILARITY	Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM3 sub-subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	TRPM3_HUMAN	Membrane {ECO 0000269|PubMed 12672827}; Multi-pass membrane protein {ECO 0000269|PubMed 12672827}. 
# TCDB	1.A.4.5	the transient receptor potential ca(2+) channel (trp-cc) family
# TISSUE SPECIFICITY	TRPM3_HUMAN	Expressed primarily in the kidney and, at lower levels, in brain, testis, ovary, pancreas and spinal cord. Expression in the brain and kidney was determined at protein level. In the kidney, expressed predominantly in the collecting tubular epithelium in the medulla, medullary rays, and periglomerular regions; in the brain, highest levels are found in the cerebellum, choroid plexus, the locus coeruleus, the posterior thalamus and the substantia nigra. Down-regulated in renal tumors compared to normal kidney. {ECO 0000269|PubMed 12672799, ECO 0000269|PubMed 12672827}. 
# UCSC	uc004aic	human. [Q9HCF6-1]
# eggNOG	ENOG410XR5B	LUCA
# eggNOG	KOG3614	Eukaryota
BLAST	swissprot:TRPM3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TRPM3_HUMAN
BioCyc	ZFISH:ENSG00000083067-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000083067-MONOMER
COXPRESdb	80036	http://coxpresdb.jp/data/gene/80036.shtml
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
DOI	10.1074/jbc.M211232200	http://dx.doi.org/10.1074/jbc.M211232200
DOI	10.1074/jbc.M300945200	http://dx.doi.org/10.1074/jbc.M300945200
DOI	10.1093/dnares/7.4.271	http://dx.doi.org/10.1093/dnares/7.4.271
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1101/gr.GR1547R	http://dx.doi.org/10.1101/gr.GR1547R
EMBL	AB046836	http://www.ebi.ac.uk/ena/data/view/AB046836
EMBL	AB099661	http://www.ebi.ac.uk/ena/data/view/AB099661
EMBL	AB099662	http://www.ebi.ac.uk/ena/data/view/AB099662
EMBL	AB099663	http://www.ebi.ac.uk/ena/data/view/AB099663
EMBL	AB099664	http://www.ebi.ac.uk/ena/data/view/AB099664
EMBL	AB099665	http://www.ebi.ac.uk/ena/data/view/AB099665
EMBL	AF536748	http://www.ebi.ac.uk/ena/data/view/AF536748
EMBL	AF536749	http://www.ebi.ac.uk/ena/data/view/AF536749
EMBL	AF536750	http://www.ebi.ac.uk/ena/data/view/AF536750
EMBL	AF536751	http://www.ebi.ac.uk/ena/data/view/AF536751
EMBL	AF536752	http://www.ebi.ac.uk/ena/data/view/AF536752
EMBL	AF536753	http://www.ebi.ac.uk/ena/data/view/AF536753
EMBL	AJ505025	http://www.ebi.ac.uk/ena/data/view/AJ505025
EMBL	AJ505026	http://www.ebi.ac.uk/ena/data/view/AJ505026
EMBL	AL136545	http://www.ebi.ac.uk/ena/data/view/AL136545
EMBL	AL159990	http://www.ebi.ac.uk/ena/data/view/AL159990
EMBL	AL159990	http://www.ebi.ac.uk/ena/data/view/AL159990
EMBL	AL159990	http://www.ebi.ac.uk/ena/data/view/AL159990
EMBL	AL159990	http://www.ebi.ac.uk/ena/data/view/AL159990
EMBL	AL159990	http://www.ebi.ac.uk/ena/data/view/AL159990
EMBL	AL159990	http://www.ebi.ac.uk/ena/data/view/AL159990
EMBL	AL159990	http://www.ebi.ac.uk/ena/data/view/AL159990
EMBL	AL160273	http://www.ebi.ac.uk/ena/data/view/AL160273
EMBL	AL161913	http://www.ebi.ac.uk/ena/data/view/AL161913
EMBL	AL161913	http://www.ebi.ac.uk/ena/data/view/AL161913
EMBL	AL161913	http://www.ebi.ac.uk/ena/data/view/AL161913
EMBL	AL161913	http://www.ebi.ac.uk/ena/data/view/AL161913
EMBL	AL161913	http://www.ebi.ac.uk/ena/data/view/AL161913
EMBL	AL356318	http://www.ebi.ac.uk/ena/data/view/AL356318
EMBL	AL356318	http://www.ebi.ac.uk/ena/data/view/AL356318
EMBL	AL356318	http://www.ebi.ac.uk/ena/data/view/AL356318
EMBL	AL356318	http://www.ebi.ac.uk/ena/data/view/AL356318
EMBL	AL356318	http://www.ebi.ac.uk/ena/data/view/AL356318
EMBL	AL356318	http://www.ebi.ac.uk/ena/data/view/AL356318
EMBL	AL356318	http://www.ebi.ac.uk/ena/data/view/AL356318
EMBL	AL358786	http://www.ebi.ac.uk/ena/data/view/AL358786
EMBL	AL358786	http://www.ebi.ac.uk/ena/data/view/AL358786
EMBL	AL358786	http://www.ebi.ac.uk/ena/data/view/AL358786
EMBL	AL358786	http://www.ebi.ac.uk/ena/data/view/AL358786
EMBL	AL358786	http://www.ebi.ac.uk/ena/data/view/AL358786
EMBL	AL391819	http://www.ebi.ac.uk/ena/data/view/AL391819
EMBL	AL442645	http://www.ebi.ac.uk/ena/data/view/AL442645
EMBL	AL442645	http://www.ebi.ac.uk/ena/data/view/AL442645
EMBL	AL442645	http://www.ebi.ac.uk/ena/data/view/AL442645
EMBL	AL442645	http://www.ebi.ac.uk/ena/data/view/AL442645
EMBL	AL442645	http://www.ebi.ac.uk/ena/data/view/AL442645
EMBL	AL592438	http://www.ebi.ac.uk/ena/data/view/AL592438
EMBL	BC121821	http://www.ebi.ac.uk/ena/data/view/BC121821
EMBL	BC134414	http://www.ebi.ac.uk/ena/data/view/BC134414
EMBL	BC142972	http://www.ebi.ac.uk/ena/data/view/BC142972
Ensembl	ENST00000361823	http://www.ensembl.org/id/ENST00000361823
Ensembl	ENST00000377110	http://www.ensembl.org/id/ENST00000377110
Ensembl	ENST00000377111	http://www.ensembl.org/id/ENST00000377111
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005227	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005227
GO_function	GO:0005261	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005261
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_process	GO:0006812	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006812
GO_process	GO:0016048	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016048
GO_process	GO:0050951	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050951
GO_process	GO:0051262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051262
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	TRPM3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TRPM3
GeneID	80036	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80036
GeneTree	ENSGT00760000119127	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119127
HGNC	HGNC:17992	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17992
HOGENOM	HOG000230920	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230920&db=HOGENOM6
HOVERGEN	HBG058254	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG058254&db=HOVERGEN
InParanoid	Q9HCF6	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9HCF6
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR029583	http://www.ebi.ac.uk/interpro/entry/IPR029583
InterPro	IPR032415	http://www.ebi.ac.uk/interpro/entry/IPR032415
Jabion	80036	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=80036
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:80036	http://www.genome.jp/dbget-bin/www_bget?hsa:80036
KEGG_Orthology	KO:K04978	http://www.genome.jp/dbget-bin/www_bget?KO:K04978
MIM	608961	http://www.ncbi.nlm.nih.gov/omim/608961
MINT	MINT-4713703	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4713703
PANTHER	PTHR13800:SF7	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13800:SF7
PSORT	swissprot:TRPM3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TRPM3_HUMAN
PSORT-B	swissprot:TRPM3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TRPM3_HUMAN
PSORT2	swissprot:TRPM3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TRPM3_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF16519	http://pfam.xfam.org/family/PF16519
PharmGKB	PA38271	http://www.pharmgkb.org/do/serve?objId=PA38271&objCls=Gene
Phobius	swissprot:TRPM3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TRPM3_HUMAN
PhylomeDB	Q9HCF6	http://phylomedb.org/?seqid=Q9HCF6
ProteinModelPortal	Q9HCF6	http://www.proteinmodelportal.org/query/uniprot/Q9HCF6
PubMed	10997877	http://www.ncbi.nlm.nih.gov/pubmed/10997877
PubMed	11230166	http://www.ncbi.nlm.nih.gov/pubmed/11230166
PubMed	12672799	http://www.ncbi.nlm.nih.gov/pubmed/12672799
PubMed	12672827	http://www.ncbi.nlm.nih.gov/pubmed/12672827
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-3295583	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3295583
RefSeq	NP_001007472	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001007472
RefSeq	NP_996831	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_996831
RefSeq	XP_011517340	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011517340
RefSeq	XP_011517341	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011517341
RefSeq	XP_011517343	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011517343
RefSeq	XP_011517346	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011517346
RefSeq	XP_011517348	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011517348
RefSeq	XP_011517349	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011517349
RefSeq	XP_016870631	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016870631
STRING	9606.ENSP00000366314	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000366314&targetmode=cogs
TCDB	1.A.4.5	http://www.tcdb.org/search/result.php?tc=1.A.4.5
UCSC	uc004aic	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004aic&org=rat
UniGene	Hs.47288	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.47288
UniProtKB	TRPM3_HUMAN	http://www.uniprot.org/uniprot/TRPM3_HUMAN
UniProtKB-AC	Q9HCF6	http://www.uniprot.org/uniprot/Q9HCF6
charge	swissprot:TRPM3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TRPM3_HUMAN
eggNOG	ENOG410XR5B	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XR5B
eggNOG	KOG3614	http://eggnogapi.embl.de/nog_data/html/tree/KOG3614
epestfind	swissprot:TRPM3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TRPM3_HUMAN
garnier	swissprot:TRPM3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TRPM3_HUMAN
helixturnhelix	swissprot:TRPM3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRPM3_HUMAN
hmoment	swissprot:TRPM3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TRPM3_HUMAN
iep	swissprot:TRPM3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TRPM3_HUMAN
inforesidue	swissprot:TRPM3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TRPM3_HUMAN
neXtProt	NX_Q9HCF6	http://www.nextprot.org/db/entry/NX_Q9HCF6
octanol	swissprot:TRPM3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TRPM3_HUMAN
pepcoil	swissprot:TRPM3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TRPM3_HUMAN
pepdigest	swissprot:TRPM3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TRPM3_HUMAN
pepinfo	swissprot:TRPM3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TRPM3_HUMAN
pepnet	swissprot:TRPM3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TRPM3_HUMAN
pepstats	swissprot:TRPM3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TRPM3_HUMAN
pepwheel	swissprot:TRPM3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TRPM3_HUMAN
pepwindow	swissprot:TRPM3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TRPM3_HUMAN
sigcleave	swissprot:TRPM3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TRPM3_HUMAN
## Database	ID	URL or Descriptions
# AltName	SCNAA_HUMAN	Peripheral nerve sodium channel 3
# AltName	SCNAA_HUMAN	Sodium channel protein type X subunit alpha
# AltName	SCNAA_HUMAN	Voltage-gated sodium channel subunit alpha Nav1.8
# DISEASE	SCNAA_HUMAN	Episodic pain syndrome, familial, 2 (FEPS2) [MIM 615551]  An autosomal dominant neurologic disorder characterized by adult- onset of paroxysmal pain mainly affecting the distal lower extremities. {ECO 0000269|PubMed 23115331}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	SCNAA_HUMAN	The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position. 
# DrugBank	DB00281	Lidocaine
# DrugBank	DB00296	Ropivacaine
# DrugBank	DB00297	Bupivacaine
# DrugBank	DB00313	Valproic Acid
# DrugBank	DB00473	Hexylcaine
# DrugBank	DB00527	Cinchocaine
# DrugBank	DB00645	Dyclonine
# DrugBank	DB00721	Procaine
# DrugBank	DB00807	Proparacaine
# DrugBank	DB00892	Oxybuprocaine
# DrugBank	DB00907	Cocaine
# DrugBank	DB00961	Mepivacaine
# DrugBank	DB01002	Levobupivacaine
# DrugBank	DB01086	Benzocaine
# DrugBank	DB01161	Chloroprocaine
# DrugBank	DB01173	Orphenadrine
# DrugBank	DB06218	Lacosamide
# Ensembl	ENST00000449082	ENSP00000390600; ENSG00000185313
# FUNCTION	SCNAA_HUMAN	Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium- selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms. {ECO 0000269|PubMed 9839820}. 
# GO_component	GO:0001518	voltage-gated sodium channel complex; IDA:BHF-UCL.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_component	GO:0071439	clathrin complex; IEA:Ensembl.
# GO_function	GO:0005248	voltage-gated sodium channel activity; IDA:BHF-UCL.
# GO_function	GO:0044325	ion channel binding; IPI:BHF-UCL.
# GO_process	GO:0002027	regulation of heart rate; IMP:BHF-UCL.
# GO_process	GO:0007600	sensory perception; TAS:ProtInc.
# GO_process	GO:0019228	neuronal action potential; IBA:GO_Central.
# GO_process	GO:0019233	sensory perception of pain; IEA:Ensembl.
# GO_process	GO:0034765	regulation of ion transmembrane transport; IDA:BHF-UCL.
# GO_process	GO:0035725	sodium ion transmembrane transport; IDA:BHF-UCL.
# GO_process	GO:0042475	odontogenesis of dentin-containing tooth; IEA:Ensembl.
# GO_process	GO:0055117	regulation of cardiac muscle contraction; IMP:BHF-UCL.
# GO_process	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization; IMP:BHF-UCL.
# GO_process	GO:0086010	membrane depolarization during action potential; IBA:GO_Central.
# GO_process	GO:0086016	AV node cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086043	bundle of His cell action potential; IMP:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.350	-; 4.
# Genevisible	Q9Y5Y9	HS
# HGNC	HGNC:10582	SCN10A
# InterPro	IPR001696	Na_channel_asu
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR010526	Na_trans_assoc
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028809	Na_channel_a10su
# KEGG_Brite	ko04040	Ion channels
# KEGG_Disease	H01391	[Nervous system disease] Familial episodic pain syndrome (FEPS)
# MIM	604427	gene
# MIM	615551	phenotype
# Organism	SCNAA_HUMAN	Homo sapiens (Human)
# Orphanet	306577	Sodium channelopathy-related small fiber neuropathy
# Orphanet	46348	Paroxysmal extreme pain disorder
# Orphanet	88642	Channelopathy-associated congenital insensitivity to pain
# Orphanet	90026	Primary erythermalgia
# PANTHER	PTHR10037:SF208	PTHR10037:SF208; 3
# PRINTS	PR00170	NACHANNEL
# PTM	SCNAA_HUMAN	Phosphorylation at Ser-1451 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents. {ECO 0000250}. 
# PTM	SCNAA_HUMAN	Ubiquitinated by NEDD4L; which promotes its endocytosis. {ECO 0000250}. 
# Pfam	PF00520	Ion_trans; 4
# Pfam	PF06512	Na_trans_assoc
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-445095	Interaction between L1 and Ankyrins
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# RecName	SCNAA_HUMAN	Sodium channel protein type 10 subunit alpha
# RefSeq	NP_001280235	NM_001293306.2
# RefSeq	NP_001280236	NM_001293307.2
# RefSeq	NP_006505	NM_006514.3
# SIMILARITY	Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 IQ domain. {ECO	0000305}.
# SUBCELLULAR LOCATION	SCNAA_HUMAN	Cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Note=It can be translocated to the cell membrane through association with S100A10. {ECO 0000250}. 
# SUBUNIT	The channel consists of an ion conducting pore forming alpha-subunit regulated by one or more associated auxiliary subunits SCN1B, SCN2B and SCN3B; electrophysiological properties may vary depending on the type of the associated beta subunits. Found in a number of complexes with PRX, DYNLT1 and PDZD2. Interacts with proteins such as FSTL1, PRX, DYNLT1, PDZD2, S100A10 and many others (By similarity). Interacts with NEDD4 and NEDD4L. {ECO	0000250}. 
# TISSUE SPECIFICITY	Expressed in the dorsal root ganglia and sciatic nerve. {ECO:0000269|PubMed	9839820}. 
# UCSC	uc003ciq	human
# eggNOG	ENOG410XNP6	LUCA
# eggNOG	KOG2301	Eukaryota
BLAST	swissprot:SCNAA_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SCNAA_HUMAN
BioCyc	ZFISH:G66-31820-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31820-MONOMER
COXPRESdb	6336	http://coxpresdb.jp/data/gene/6336.shtml
CleanEx	HS_SCN10A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SCN10A
DOI	10.1016/S0304-3959(98)00120-1	http://dx.doi.org/10.1016/S0304-3959(98)00120-1
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1038/nature09639	http://dx.doi.org/10.1038/nature09639
DOI	10.1073/pnas.1216080109	http://dx.doi.org/10.1073/pnas.1216080109
DrugBank	DB00281	http://www.drugbank.ca/drugs/DB00281
DrugBank	DB00296	http://www.drugbank.ca/drugs/DB00296
DrugBank	DB00297	http://www.drugbank.ca/drugs/DB00297
DrugBank	DB00313	http://www.drugbank.ca/drugs/DB00313
DrugBank	DB00473	http://www.drugbank.ca/drugs/DB00473
DrugBank	DB00527	http://www.drugbank.ca/drugs/DB00527
DrugBank	DB00645	http://www.drugbank.ca/drugs/DB00645
DrugBank	DB00721	http://www.drugbank.ca/drugs/DB00721
DrugBank	DB00807	http://www.drugbank.ca/drugs/DB00807
DrugBank	DB00892	http://www.drugbank.ca/drugs/DB00892
DrugBank	DB00907	http://www.drugbank.ca/drugs/DB00907
DrugBank	DB00961	http://www.drugbank.ca/drugs/DB00961
DrugBank	DB01002	http://www.drugbank.ca/drugs/DB01002
DrugBank	DB01086	http://www.drugbank.ca/drugs/DB01086
DrugBank	DB01161	http://www.drugbank.ca/drugs/DB01161
DrugBank	DB01173	http://www.drugbank.ca/drugs/DB01173
DrugBank	DB06218	http://www.drugbank.ca/drugs/DB06218
EMBL	AC116038	http://www.ebi.ac.uk/ena/data/view/AC116038
EMBL	AC137625	http://www.ebi.ac.uk/ena/data/view/AC137625
EMBL	AF117907	http://www.ebi.ac.uk/ena/data/view/AF117907
Ensembl	ENST00000449082	http://www.ensembl.org/id/ENST00000449082
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0001518	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001518
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_component	GO:0071439	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071439
GO_function	GO:0005248	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005248
GO_function	GO:0044325	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044325
GO_process	GO:0002027	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002027
GO_process	GO:0007600	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007600
GO_process	GO:0019228	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019228
GO_process	GO:0019233	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019233
GO_process	GO:0034765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034765
GO_process	GO:0035725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035725
GO_process	GO:0042475	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042475
GO_process	GO:0055117	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055117
GO_process	GO:0060371	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060371
GO_process	GO:0086010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086010
GO_process	GO:0086016	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086016
GO_process	GO:0086043	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086043
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	SCN10A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SCN10A
GeneID	6336	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6336
GeneTree	ENSGT00830000128242	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00830000128242
H-InvDB	HIX0030722	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0030722
HGNC	HGNC:10582	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10582
HOGENOM	HOG000231755	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231755&db=HOGENOM6
HOVERGEN	HBG053100	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053100&db=HOVERGEN
InParanoid	Q9Y5Y9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y5Y9
InterPro	IPR001696	http://www.ebi.ac.uk/interpro/entry/IPR001696
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR010526	http://www.ebi.ac.uk/interpro/entry/IPR010526
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028809	http://www.ebi.ac.uk/interpro/entry/IPR028809
Jabion	6336	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6336
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H01391	http://www.genome.jp/dbget-bin/www_bget?H01391
KEGG_Gene	hsa:6336	http://www.genome.jp/dbget-bin/www_bget?hsa:6336
KEGG_Orthology	KO:K04842	http://www.genome.jp/dbget-bin/www_bget?KO:K04842
MIM	604427	http://www.ncbi.nlm.nih.gov/omim/604427
MIM	615551	http://www.ncbi.nlm.nih.gov/omim/615551
OMA	MAMEHHG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MAMEHHG
Orphanet	306577	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=306577
Orphanet	46348	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=46348
Orphanet	88642	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=88642
Orphanet	90026	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=90026
OrthoDB	EOG091G00FK	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00FK
PANTHER	PTHR10037:SF208	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10037:SF208
PRINTS	PR00170	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00170
PSORT	swissprot:SCNAA_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SCNAA_HUMAN
PSORT-B	swissprot:SCNAA_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SCNAA_HUMAN
PSORT2	swissprot:SCNAA_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SCNAA_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF06512	http://pfam.xfam.org/family/PF06512
PharmGKB	PA35000	http://www.pharmgkb.org/do/serve?objId=PA35000&objCls=Gene
Phobius	swissprot:SCNAA_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SCNAA_HUMAN
PhylomeDB	Q9Y5Y9	http://phylomedb.org/?seqid=Q9Y5Y9
ProteinModelPortal	Q9Y5Y9	http://www.proteinmodelportal.org/query/uniprot/Q9Y5Y9
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	21248752	http://www.ncbi.nlm.nih.gov/pubmed/21248752
PubMed	23115331	http://www.ncbi.nlm.nih.gov/pubmed/23115331
PubMed	9839820	http://www.ncbi.nlm.nih.gov/pubmed/9839820
Reactome	R-HSA-445095	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-445095
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
RefSeq	NP_001280235	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001280235
RefSeq	NP_001280236	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001280236
RefSeq	NP_006505	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006505
STRING	9606.ENSP00000390600	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000390600&targetmode=cogs
UCSC	uc003ciq	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ciq&org=rat
UniGene	Hs.250443	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.250443
UniProtKB	SCNAA_HUMAN	http://www.uniprot.org/uniprot/SCNAA_HUMAN
UniProtKB-AC	Q9Y5Y9	http://www.uniprot.org/uniprot/Q9Y5Y9
charge	swissprot:SCNAA_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SCNAA_HUMAN
eggNOG	ENOG410XNP6	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNP6
eggNOG	KOG2301	http://eggnogapi.embl.de/nog_data/html/tree/KOG2301
epestfind	swissprot:SCNAA_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SCNAA_HUMAN
garnier	swissprot:SCNAA_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SCNAA_HUMAN
helixturnhelix	swissprot:SCNAA_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SCNAA_HUMAN
hmoment	swissprot:SCNAA_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SCNAA_HUMAN
iep	swissprot:SCNAA_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SCNAA_HUMAN
inforesidue	swissprot:SCNAA_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SCNAA_HUMAN
neXtProt	NX_Q9Y5Y9	http://www.nextprot.org/db/entry/NX_Q9Y5Y9
octanol	swissprot:SCNAA_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SCNAA_HUMAN
pepcoil	swissprot:SCNAA_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SCNAA_HUMAN
pepdigest	swissprot:SCNAA_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SCNAA_HUMAN
pepinfo	swissprot:SCNAA_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SCNAA_HUMAN
pepnet	swissprot:SCNAA_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SCNAA_HUMAN
pepstats	swissprot:SCNAA_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SCNAA_HUMAN
pepwheel	swissprot:SCNAA_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SCNAA_HUMAN
pepwindow	swissprot:SCNAA_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SCNAA_HUMAN
sigcleave	swissprot:SCNAA_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SCNAA_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	106858	8
# CDD	cd00333	MIP
# DISEASE	AQP5_HUMAN	Keratoderma, palmoplantar, Bothnian type (PPKB) [MIM 600231]  A dermatological disorder characterized by diffuse non-epidermolytic hyperkeratosis of the skin of palms and soles. PPKB is frequently complicated by fungal infections. {ECO 0000269|PubMed 23830519}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	AQP5_HUMAN	Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). 
# Ensembl	ENST00000293599	ENSP00000293599; ENSG00000161798
# FUNCTION	AQP5_HUMAN	Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. Required for TRPV4 activation by hypotonicity (PubMed 16571723). Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed 16571723). {ECO 0000269|PubMed 16571723}. 
# GO_component	GO:0005783	endoplasmic reticulum; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0005902	microvillus; IEA:Ensembl.
# GO_component	GO:0009925	basal plasma membrane; IEA:Ensembl.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0015250	water channel activity; IDA:UniProtKB.
# GO_function	GO:0015254	glycerol channel activity; IBA:GO_Central.
# GO_process	GO:0006833	water transport; TAS:Reactome.
# GO_process	GO:0007588	excretion; TAS:ProtInc.
# GO_process	GO:0009992	cellular water homeostasis; IBA:GO_Central.
# GO_process	GO:0015670	carbon dioxide transport; IDA:UniProtKB.
# GO_process	GO:0030157	pancreatic juice secretion; IEP:UniProtKB.
# GO_process	GO:0034220	ion transmembrane transport; IBA:GO_Central.
# GO_process	GO:0042476	odontogenesis; IEP:UniProtKB.
# GO_process	GO:0046541	saliva secretion; IEA:Ensembl.
# GO_process	GO:0048593	camera-type eye morphogenesis; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.1080.10	-; 1.
# Genevisible	P55064	HS
# HGNC	HGNC:638	AQP5
# INTERACTION	AQP5_HUMAN	Q6IBN1 HNRPK; NbExp=3; IntAct=EBI-746103, EBI-3440248; Q15323 KRT31; NbExp=3; IntAct=EBI-746103, EBI-948001; Q6A162 KRT40; NbExp=3; IntAct=EBI-746103, EBI-10171697; Q99750 MDFI; NbExp=3; IntAct=EBI-746103, EBI-724076; Q7Z3S9 NOTCH2NL; NbExp=3; IntAct=EBI-746103, EBI-945833; 
# IntAct	P55064	8
# InterPro	IPR000425	MIP
# InterPro	IPR022357	MIP_CS
# InterPro	IPR023271	Aquaporin-like
# InterPro	IPR023276	Aquaporin_5
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H01673	[Skin and connective tissue disease] Palmoplantar keratoderma
# KEGG_Pathway	ko04970	Salivary secretion
# MIM	600231	phenotype
# MIM	600442	gene
# Organism	AQP5_HUMAN	Homo sapiens (Human)
# Orphanet	2337	Non-epidermolytic palmoplantar keratoderma
# PANTHER	PTHR19139	PTHR19139
# PDB	3D9S	X-ray; 2.00 A; A/B/C/D=2-265
# PDB	5C5X	X-ray; 2.60 A; A/B/C/D/E/F/G/H=1-245
# PDB	5DYE	X-ray; 3.50 A; A/B/C/D=1-265
# PRINTS	PR00783	MINTRINSICP
# PRINTS	PR02017	AQUAPORIN5
# PROSITE	PS00221	MIP
# Pfam	PF00230	MIP
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-432047	Passive transport by Aquaporins
# RecName	AQP5_HUMAN	Aquaporin-5
# RefSeq	NP_001642	NM_001651.3
# SIMILARITY	Belongs to the MIP/aquaporin (TC 1.A.8) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	AQP5_HUMAN	Apical cell membrane {ECO 0000250|UniProtKB Q9WTY4}; Multi-pass membrane protein {ECO 0000255}. 
# SUBUNIT	Interacts with TRPV4; the interaction is probably indirect and regulates TRPV4 activation by hypotonicity. {ECO:0000269|PubMed	16571723}. 
# SUPFAM	SSF81338	SSF81338
# TCDB	1.A.8.8	the major intrinsic protein (mip) family
# TIGRFAMs	TIGR00861	MIP
# UCSC	uc001rvo	human
# eggNOG	COG0580	LUCA
# eggNOG	KOG0223	Eukaryota
BLAST	swissprot:AQP5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AQP5_HUMAN
BioCyc	ZFISH:ENSG00000161798-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000161798-MONOMER
COXPRESdb	362	http://coxpresdb.jp/data/gene/362.shtml
CleanEx	HS_AQP5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AQP5
DIP	DIP-46292N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-46292N
DOI	10.1016/j.ajhg.2013.06.008	http://dx.doi.org/10.1016/j.ajhg.2013.06.008
DOI	10.1074/jbc.271.15.8599	http://dx.doi.org/10.1074/jbc.271.15.8599
DOI	10.1074/jbc.M600549200	http://dx.doi.org/10.1074/jbc.M600549200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	BC032946	http://www.ebi.ac.uk/ena/data/view/BC032946
EMBL	CR541989	http://www.ebi.ac.uk/ena/data/view/CR541989
EMBL	CR542022	http://www.ebi.ac.uk/ena/data/view/CR542022
EMBL	U46566	http://www.ebi.ac.uk/ena/data/view/U46566
EMBL	U46567	http://www.ebi.ac.uk/ena/data/view/U46567
EMBL	U46568	http://www.ebi.ac.uk/ena/data/view/U46568
EMBL	U46569	http://www.ebi.ac.uk/ena/data/view/U46569
Ensembl	ENST00000293599	http://www.ensembl.org/id/ENST00000293599
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005902
GO_component	GO:0009925	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009925
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0015250	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015250
GO_function	GO:0015254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015254
GO_process	GO:0006833	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006833
GO_process	GO:0007588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007588
GO_process	GO:0009992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009992
GO_process	GO:0015670	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015670
GO_process	GO:0030157	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030157
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0042476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042476
GO_process	GO:0046541	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046541
GO_process	GO:0048593	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048593
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.1080.10	http://www.cathdb.info/version/latest/superfamily/1.20.1080.10
GeneCards	AQP5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=AQP5
GeneID	362	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=362
GeneTree	ENSGT00760000119223	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119223
HGNC	HGNC:638	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:638
HOGENOM	HOG000288286	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000288286&db=HOGENOM6
HOVERGEN	HBG000312	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000312&db=HOVERGEN
HPA	HPA065008	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA065008
InParanoid	P55064	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P55064
IntAct	P55064	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P55064*
InterPro	IPR000425	http://www.ebi.ac.uk/interpro/entry/IPR000425
InterPro	IPR022357	http://www.ebi.ac.uk/interpro/entry/IPR022357
InterPro	IPR023271	http://www.ebi.ac.uk/interpro/entry/IPR023271
InterPro	IPR023276	http://www.ebi.ac.uk/interpro/entry/IPR023276
Jabion	362	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=362
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H01673	http://www.genome.jp/dbget-bin/www_bget?H01673
KEGG_Gene	hsa:362	http://www.genome.jp/dbget-bin/www_bget?hsa:362
KEGG_Orthology	KO:K09867	http://www.genome.jp/dbget-bin/www_bget?KO:K09867
KEGG_Pathway	ko04970	http://www.genome.jp/kegg-bin/show_pathway?ko04970
MIM	600231	http://www.ncbi.nlm.nih.gov/omim/600231
MIM	600442	http://www.ncbi.nlm.nih.gov/omim/600442
MINT	MINT-1442891	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1442891
OMA	NISGCHV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NISGCHV
Orphanet	2337	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=2337
OrthoDB	EOG091G166T	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G166T
PANTHER	PTHR19139	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19139
PDB	3D9S	http://www.ebi.ac.uk/pdbe-srv/view/entry/3D9S
PDB	5C5X	http://www.ebi.ac.uk/pdbe-srv/view/entry/5C5X
PDB	5DYE	http://www.ebi.ac.uk/pdbe-srv/view/entry/5DYE
PDBsum	3D9S	http://www.ebi.ac.uk/pdbsum/3D9S
PDBsum	5C5X	http://www.ebi.ac.uk/pdbsum/5C5X
PDBsum	5DYE	http://www.ebi.ac.uk/pdbsum/5DYE
PRINTS	PR00783	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00783
PRINTS	PR02017	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR02017
PROSITE	PS00221	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00221
PSORT	swissprot:AQP5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AQP5_HUMAN
PSORT-B	swissprot:AQP5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AQP5_HUMAN
PSORT2	swissprot:AQP5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AQP5_HUMAN
Pfam	PF00230	http://pfam.xfam.org/family/PF00230
PharmGKB	PA24923	http://www.pharmgkb.org/do/serve?objId=PA24923&objCls=Gene
Phobius	swissprot:AQP5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AQP5_HUMAN
PhylomeDB	P55064	http://phylomedb.org/?seqid=P55064
ProteinModelPortal	P55064	http://www.proteinmodelportal.org/query/uniprot/P55064
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16571723	http://www.ncbi.nlm.nih.gov/pubmed/16571723
PubMed	23830519	http://www.ncbi.nlm.nih.gov/pubmed/23830519
PubMed	8621489	http://www.ncbi.nlm.nih.gov/pubmed/8621489
Reactome	R-HSA-432047	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432047
RefSeq	NP_001642	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001642
SMR	P55064	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P55064
STRING	9606.ENSP00000293599	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000293599&targetmode=cogs
SUPFAM	SSF81338	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81338
TCDB	1.A.8.8	http://www.tcdb.org/search/result.php?tc=1.A.8.8
TIGRFAMs	TIGR00861	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00861
UCSC	uc001rvo	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001rvo&org=rat
UniGene	Hs.298023	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.298023
UniProtKB	AQP5_HUMAN	http://www.uniprot.org/uniprot/AQP5_HUMAN
UniProtKB-AC	P55064	http://www.uniprot.org/uniprot/P55064
charge	swissprot:AQP5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AQP5_HUMAN
eggNOG	COG0580	http://eggnogapi.embl.de/nog_data/html/tree/COG0580
eggNOG	KOG0223	http://eggnogapi.embl.de/nog_data/html/tree/KOG0223
epestfind	swissprot:AQP5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AQP5_HUMAN
garnier	swissprot:AQP5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AQP5_HUMAN
helixturnhelix	swissprot:AQP5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AQP5_HUMAN
hmoment	swissprot:AQP5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AQP5_HUMAN
iep	swissprot:AQP5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AQP5_HUMAN
inforesidue	swissprot:AQP5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AQP5_HUMAN
neXtProt	NX_P55064	http://www.nextprot.org/db/entry/NX_P55064
octanol	swissprot:AQP5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AQP5_HUMAN
pepcoil	swissprot:AQP5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AQP5_HUMAN
pepdigest	swissprot:AQP5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AQP5_HUMAN
pepinfo	swissprot:AQP5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AQP5_HUMAN
pepnet	swissprot:AQP5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AQP5_HUMAN
pepstats	swissprot:AQP5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AQP5_HUMAN
pepwheel	swissprot:AQP5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AQP5_HUMAN
pepwindow	swissprot:AQP5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AQP5_HUMAN
sigcleave	swissprot:AQP5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AQP5_HUMAN
## Database	ID	URL or Descriptions
# AltName	TSCOT_HUMAN	Solute carrier family 46 member 2
# Ensembl	ENST00000374228	ENSP00000363345; ENSG00000119457
# ExpressionAtlas	Q9BY10	baseline and differential
# FUNCTION	TSCOT_HUMAN	May act as a transporter. {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0009986	cell surface; IEA:Ensembl.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_function	GO:0015293	symporter activity; NAS:UniProtKB.
# GO_process	GO:0043029	T cell homeostasis; IEA:Ensembl.
# GO_process	GO:0045580	regulation of T cell differentiation; IEA:Ensembl.
# GO_process	GO:0048538	thymus development; IEA:Ensembl.
# GO_process	GO:0070233	negative regulation of T cell apoptotic process; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# Genevisible	Q9BY10	HS
# HGNC	HGNC:16055	SLC46A2
# InterPro	IPR001958	Tet-R_TetA/multi-R_MdtG
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	608956	gene
# Organism	TSCOT_HUMAN	Homo sapiens (Human)
# PRINTS	PR01035	TCRTETA
# PTM	TSCOT_HUMAN	Glycosylated. {ECO 0000250}. 
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 9
# RecName	TSCOT_HUMAN	Thymic stromal cotransporter homolog
# RefSeq	NP_149040	NM_033051.3
# SIMILARITY	Belongs to the major facilitator superfamily. SLC46A family. {ECO	0000305}.
# SUBCELLULAR LOCATION	TSCOT_HUMAN	Cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.50	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	Strongly expressed in the adult thymus. Expressed in spleen, lymph nodes, thymus, PBL, bone marrow and fetal liver. {ECO:0000269|PubMed	10978518}. 
# UCSC	uc004bgk	human
# eggNOG	ENOG410ISYW	Eukaryota
# eggNOG	ENOG410YS8M	LUCA
BLAST	swissprot:TSCOT_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TSCOT_HUMAN
BioCyc	ZFISH:ENSG00000119457-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000119457-MONOMER
COXPRESdb	57864	http://coxpresdb.jp/data/gene/57864.shtml
CleanEx	HS_SLC46A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC46A2
DOI	10.1016/S0167-4781(00)00177-9	http://dx.doi.org/10.1016/S0167-4781(00)00177-9
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF242557	http://www.ebi.ac.uk/ena/data/view/AF242557
EMBL	AK055571	http://www.ebi.ac.uk/ena/data/view/AK055571
EMBL	AK314414	http://www.ebi.ac.uk/ena/data/view/AK314414
EMBL	AL139041	http://www.ebi.ac.uk/ena/data/view/AL139041
EMBL	BC048285	http://www.ebi.ac.uk/ena/data/view/BC048285
EMBL	CH878453	http://www.ebi.ac.uk/ena/data/view/CH878453
Ensembl	ENST00000374228	http://www.ensembl.org/id/ENST00000374228
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_process	GO:0043029	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043029
GO_process	GO:0045580	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045580
GO_process	GO:0048538	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048538
GO_process	GO:0070233	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070233
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GeneCards	SLC46A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC46A2
GeneID	57864	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57864
GeneTree	ENSGT00530000063076	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063076
HGNC	HGNC:16055	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16055
HOGENOM	HOG000231710	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231710&db=HOGENOM6
HOVERGEN	HBG054696	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054696&db=HOVERGEN
HPA	HPA020098	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA020098
InParanoid	Q9BY10	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9BY10
InterPro	IPR001958	http://www.ebi.ac.uk/interpro/entry/IPR001958
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	57864	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=57864
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:57864	http://www.genome.jp/dbget-bin/www_bget?hsa:57864
KEGG_Orthology	KO:K14614	http://www.genome.jp/dbget-bin/www_bget?KO:K14614
MIM	608956	http://www.ncbi.nlm.nih.gov/omim/608956
OMA	YAVGHPP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YAVGHPP
OrthoDB	EOG091G08MP	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08MP
PRINTS	PR01035	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01035
PSORT	swissprot:TSCOT_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TSCOT_HUMAN
PSORT-B	swissprot:TSCOT_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TSCOT_HUMAN
PSORT2	swissprot:TSCOT_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TSCOT_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA162403790	http://www.pharmgkb.org/do/serve?objId=PA162403790&objCls=Gene
Phobius	swissprot:TSCOT_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TSCOT_HUMAN
PhylomeDB	Q9BY10	http://phylomedb.org/?seqid=Q9BY10
ProteinModelPortal	Q9BY10	http://www.proteinmodelportal.org/query/uniprot/Q9BY10
PubMed	10978518	http://www.ncbi.nlm.nih.gov/pubmed/10978518
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
RefSeq	NP_149040	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_149040
STRING	9606.ENSP00000363345	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000363345&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.50	http://www.tcdb.org/search/result.php?tc=2.A.1.50
UCSC	uc004bgk	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004bgk&org=rat
UniGene	Hs.512668	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.512668
UniProtKB	TSCOT_HUMAN	http://www.uniprot.org/uniprot/TSCOT_HUMAN
UniProtKB-AC	Q9BY10	http://www.uniprot.org/uniprot/Q9BY10
charge	swissprot:TSCOT_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TSCOT_HUMAN
eggNOG	ENOG410ISYW	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ISYW
eggNOG	ENOG410YS8M	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YS8M
epestfind	swissprot:TSCOT_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TSCOT_HUMAN
garnier	swissprot:TSCOT_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TSCOT_HUMAN
helixturnhelix	swissprot:TSCOT_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TSCOT_HUMAN
hmoment	swissprot:TSCOT_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TSCOT_HUMAN
iep	swissprot:TSCOT_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TSCOT_HUMAN
inforesidue	swissprot:TSCOT_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TSCOT_HUMAN
neXtProt	NX_Q9BY10	http://www.nextprot.org/db/entry/NX_Q9BY10
octanol	swissprot:TSCOT_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TSCOT_HUMAN
pepcoil	swissprot:TSCOT_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TSCOT_HUMAN
pepdigest	swissprot:TSCOT_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TSCOT_HUMAN
pepinfo	swissprot:TSCOT_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TSCOT_HUMAN
pepnet	swissprot:TSCOT_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TSCOT_HUMAN
pepstats	swissprot:TSCOT_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TSCOT_HUMAN
pepwheel	swissprot:TSCOT_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TSCOT_HUMAN
pepwindow	swissprot:TSCOT_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TSCOT_HUMAN
sigcleave	swissprot:TSCOT_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TSCOT_HUMAN
## Database	ID	URL or Descriptions
# AltName	S39A5_HUMAN	Solute carrier family 39 member 5
# AltName	S39A5_HUMAN	Zrt- and Irt-like protein 5
# BioGrid	129541	45
# CAUTION	It is uncertain whether Met-1 or Met-2 is the initiator. {ECO	0000305}. 
# DISEASE	S39A5_HUMAN	Myopia 24, autosomal dominant (MYP24) [MIM 615946]  A refractive error of the eye, in which parallel rays from a distant object come to focus in front of the retina, vision being better for near objects than for far. {ECO 0000269|PubMed 24891338, ECO 0000269|PubMed 25525168}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000266980	ENSP00000266980; ENSG00000139540
# Ensembl	ENST00000454355	ENSP00000405360; ENSG00000139540
# ExpressionAtlas	Q6ZMH5	baseline and differential
# FUNCTION	S39A5_HUMAN	May play a role in polarized cells by carrying out serosal-to-mucosal zinc transport. Plays a role in eye development. Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera (PubMed 24891338). Seems to play a central role in controlling organismal zinc status (By similarity). {ECO 0000250|UniProtKB Q9D856, ECO 0000269|PubMed 24891338}. 
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005385	zinc ion transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0001654	eye development; IMP:UniProtKB.
# GO_process	GO:0006882	cellular zinc ion homeostasis; IBA:GO_Central.
# GO_process	GO:0030509	BMP signaling pathway; IMP:UniProtKB.
# GO_process	GO:0034224	cellular response to zinc ion starvation; IEA:Ensembl.
# GO_process	GO:0048026	positive regulation of mRNA splicing, via spliceosome; IEA:Ensembl.
# GO_process	GO:0061351	neural precursor cell proliferation; ISS:UniProtKB.
# GO_process	GO:0070315	G1 to G0 transition involved in cell differentiation; ISS:UniProtKB.
# GO_process	GO:0071578	zinc II ion transmembrane import; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0008283	cell proliferation
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q6ZMH5	HS
# HGNC	HGNC:20502	SLC39A5
# InterPro	IPR003689	ZIP
# KEGG_Brite	ko02001	Solute carrier family
# MIM	608730	gene
# MIM	615946	phenotype
# Organism	S39A5_HUMAN	Homo sapiens (Human)
# PTM	S39A5_HUMAN	Glycosylated. {ECO 0000250}. 
# Pfam	PF02535	Zip
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-442380	Zinc influx into cells by the SLC39 gene family
# RecName	S39A5_HUMAN	Zinc transporter ZIP5
# RefSeq	NP_001128667	NM_001135195.1
# RefSeq	NP_775867	NM_173596.2
# RefSeq	XP_005268860	XM_005268803.1
# RefSeq	XP_011536500	XM_011538198.1
# RefSeq	XP_011536501	XM_011538199.1
# RefSeq	XP_011536502	XM_011538200.1
# RefSeq	XP_011536503	XM_011538201.1
# SEQUENCE CAUTION	Sequence=AAH27884.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG36005.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the ZIP transporter (TC 2.A.5) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S39A5_HUMAN	Basolateral cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# TCDB	2.A.5.4.10	the zinc (zn(2+))-iron (fe(2+)) permease (zip) family
# TISSUE SPECIFICITY	Expressed in liver, kidney, pancreas, small intestine, colon, spleen, fetal liver and fetal kidney. {ECO:0000269|PubMed	15322118}. 
# UCSC	uc010sqj	human
# eggNOG	COG0428	LUCA
# eggNOG	KOG2693	Eukaryota
BLAST	swissprot:S39A5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S39A5_HUMAN
COXPRESdb	283375	http://coxpresdb.jp/data/gene/283375.shtml
CleanEx	HS_SLC39A5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC39A5
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M408361200	http://dx.doi.org/10.1074/jbc.M408361200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1136/jmedgenet-2014-102351	http://dx.doi.org/10.1136/jmedgenet-2014-102351
DOI	10.1167/iovs.14-14850	http://dx.doi.org/10.1167/iovs.14-14850
EMBL	AK172768	http://www.ebi.ac.uk/ena/data/view/AK172768
EMBL	AK313188	http://www.ebi.ac.uk/ena/data/view/AK313188
EMBL	BC027884	http://www.ebi.ac.uk/ena/data/view/BC027884
Ensembl	ENST00000266980	http://www.ensembl.org/id/ENST00000266980
Ensembl	ENST00000454355	http://www.ensembl.org/id/ENST00000454355
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005385
GO_process	GO:0001654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001654
GO_process	GO:0006882	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006882
GO_process	GO:0030509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030509
GO_process	GO:0034224	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034224
GO_process	GO:0048026	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048026
GO_process	GO:0061351	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061351
GO_process	GO:0070315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070315
GO_process	GO:0071578	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071578
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0008283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008283
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC39A5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC39A5
GeneID	283375	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=283375
GeneTree	ENSGT00760000119115	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119115
HGNC	HGNC:20502	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20502
HOGENOM	HOG000132930	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000132930&db=HOGENOM6
HOVERGEN	HBG084379	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG084379&db=HOVERGEN
HPA	HPA018423	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA018423
InParanoid	Q6ZMH5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6ZMH5
InterPro	IPR003689	http://www.ebi.ac.uk/interpro/entry/IPR003689
Jabion	283375	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=283375
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:283375	http://www.genome.jp/dbget-bin/www_bget?hsa:283375
KEGG_Orthology	KO:K14711	http://www.genome.jp/dbget-bin/www_bget?KO:K14711
MIM	608730	http://www.ncbi.nlm.nih.gov/omim/608730
MIM	615946	http://www.ncbi.nlm.nih.gov/omim/615946
OMA	ENGSGMA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ENGSGMA
OrthoDB	EOG091G0G6G	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0G6G
PSORT	swissprot:S39A5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S39A5_HUMAN
PSORT-B	swissprot:S39A5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S39A5_HUMAN
PSORT2	swissprot:S39A5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S39A5_HUMAN
Pfam	PF02535	http://pfam.xfam.org/family/PF02535
PharmGKB	PA134872687	http://www.pharmgkb.org/do/serve?objId=PA134872687&objCls=Gene
Phobius	swissprot:S39A5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S39A5_HUMAN
PhylomeDB	Q6ZMH5	http://phylomedb.org/?seqid=Q6ZMH5
ProteinModelPortal	Q6ZMH5	http://www.proteinmodelportal.org/query/uniprot/Q6ZMH5
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15322118	http://www.ncbi.nlm.nih.gov/pubmed/15322118
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	24891338	http://www.ncbi.nlm.nih.gov/pubmed/24891338
PubMed	25525168	http://www.ncbi.nlm.nih.gov/pubmed/25525168
Reactome	R-HSA-442380	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442380
RefSeq	NP_001128667	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001128667
RefSeq	NP_775867	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_775867
RefSeq	XP_005268860	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005268860
RefSeq	XP_011536500	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011536500
RefSeq	XP_011536501	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011536501
RefSeq	XP_011536502	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011536502
RefSeq	XP_011536503	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011536503
SMR	Q6ZMH5	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q6ZMH5
STRING	9606.ENSP00000266980	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000266980&targetmode=cogs
TCDB	2.A.5.4.10	http://www.tcdb.org/search/result.php?tc=2.A.5.4.10
UCSC	uc010sqj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010sqj&org=rat
UniGene	Hs.591018	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.591018
UniProtKB	S39A5_HUMAN	http://www.uniprot.org/uniprot/S39A5_HUMAN
UniProtKB-AC	Q6ZMH5	http://www.uniprot.org/uniprot/Q6ZMH5
charge	swissprot:S39A5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S39A5_HUMAN
eggNOG	COG0428	http://eggnogapi.embl.de/nog_data/html/tree/COG0428
eggNOG	KOG2693	http://eggnogapi.embl.de/nog_data/html/tree/KOG2693
epestfind	swissprot:S39A5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S39A5_HUMAN
garnier	swissprot:S39A5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S39A5_HUMAN
helixturnhelix	swissprot:S39A5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S39A5_HUMAN
hmoment	swissprot:S39A5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S39A5_HUMAN
iep	swissprot:S39A5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S39A5_HUMAN
inforesidue	swissprot:S39A5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S39A5_HUMAN
neXtProt	NX_Q6ZMH5	http://www.nextprot.org/db/entry/NX_Q6ZMH5
octanol	swissprot:S39A5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S39A5_HUMAN
pepcoil	swissprot:S39A5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S39A5_HUMAN
pepdigest	swissprot:S39A5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S39A5_HUMAN
pepinfo	swissprot:S39A5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S39A5_HUMAN
pepnet	swissprot:S39A5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S39A5_HUMAN
pepstats	swissprot:S39A5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S39A5_HUMAN
pepwheel	swissprot:S39A5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S39A5_HUMAN
pepwindow	swissprot:S39A5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S39A5_HUMAN
sigcleave	swissprot:S39A5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S39A5_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCJ12_HUMAN	Inward rectifier K(+) channel Kir2.2
# AltName	KCJ12_HUMAN	Inward rectifier K(+) channel Kir2.2v
# AltName	KCJ12_HUMAN	Potassium channel, inwardly rectifying subfamily J member 12
# BioGrid	109970	16
# ChiTaRS	KCNJ12	human
# DOMAIN	KCJ12_HUMAN	Phosphatidylinositol 4,5-bisphosphate binding to the cytoplasmic side of the channel triggers a conformation change leading to channel opening. {ECO 0000250}. 
# DrugBank	DB00204	Dofetilide
# DrugBank	DB01392	Yohimbine
# Ensembl	ENST00000331718	ENSP00000328150; ENSG00000184185
# Ensembl	ENST00000583088	ENSP00000463778; ENSG00000184185
# FUNCTION	KCJ12_HUMAN	Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. {ECO 0000269|PubMed 12417321, ECO 0000269|PubMed 20921230, ECO 0000269|PubMed 7859381, ECO 0000269|PubMed 8647284}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0031224	intrinsic component of membrane; IDA:UniProtKB.
# GO_function	GO:0005242	inward rectifier potassium channel activity; IDA:UniProtKB.
# GO_function	GO:0015467	G-protein activated inward rectifier potassium channel activity; TAS:Reactome.
# GO_process	GO:0006813	potassium ion transport; IDA:UniProtKB.
# GO_process	GO:0006936	muscle contraction; TAS:ProtInc.
# GO_process	GO:0008016	regulation of heart contraction; TAS:ProtInc.
# GO_process	GO:0010107	potassium ion import; IBA:GO_Central.
# GO_process	GO:0051289	protein homotetramerization; IDA:UniProtKB.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.40.1400	-; 1.
# Genevisible	Q14500	HS
# HGNC	HGNC:6258	KCNJ12
# InterPro	IPR003272	K_chnl_inward-rec_Kir2.2
# InterPro	IPR013518	K_chnl_inward-rec_Kir_cyto
# InterPro	IPR013673	K_chnl_inward-rec_Kir_N
# InterPro	IPR014756	Ig_E-set
# InterPro	IPR016449	K_chnl_inward-rec_Kir
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04725	Cholinergic synapse
# MIM	602323	gene
# Organism	KCJ12_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11767	PTHR11767
# PANTHER	PTHR11767:SF14	PTHR11767:SF14
# PIR	I52864	I52864
# PIR	S71341	S71341
# PRINTS	PR01320	KIRCHANNEL
# PRINTS	PR01325	KIR22CHANNEL
# Pfam	PF01007	IRK
# Pfam	PF08466	IRK_N
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-1296041	Activation of G protein gated Potassium channels
# Reactome	R-HSA-1296053	Classical Kir channels
# Reactome	R-HSA-5576886	Phase 4 - resting membrane potential
# Reactome	R-HSA-997272	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
# RecName	KCJ12_HUMAN	ATP-sensitive inward rectifier potassium channel 12
# RefSeq	NP_066292	NM_021012.4
# RefSeq	XP_005256682	XM_005256625.4
# RefSeq	XP_011522133	XM_011523831.2
# SIMILARITY	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ12 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCJ12_HUMAN	Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role in its localization and trafficking (By similarity). Homotetramer. Forms heteromer with KCNJ4. {ECO:0000250, ECO	0000269|PubMed:20921230}. 
# SUPFAM	SSF81296	SSF81296
# TCDB	1.A.2.1	inward rectifier k(+) channel (irk-c) family
# UCSC	uc002gyv	human
# eggNOG	ENOG410XQ62	LUCA
# eggNOG	KOG3827	Eukaryota
BLAST	swissprot:KCJ12_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCJ12_HUMAN
BioCyc	ZFISH:G66-31140-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31140-MONOMER
COXPRESdb	3768	http://coxpresdb.jp/data/gene/3768.shtml
DOI	10.1016/0014-5793(96)00445-0	http://dx.doi.org/10.1016/0014-5793(96)00445-0
DOI	10.1016/S0014-5793(02)03512-3	http://dx.doi.org/10.1016/S0014-5793(02)03512-3
DOI	10.1073/pnas.102609499	http://dx.doi.org/10.1073/pnas.102609499
DOI	10.1074/jbc.273.3.1339	http://dx.doi.org/10.1074/jbc.273.3.1339
DOI	10.1074/jbc.C110.186692	http://dx.doi.org/10.1074/jbc.C110.186692
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1161/01.RES.76.3.343	http://dx.doi.org/10.1161/01.RES.76.3.343
DrugBank	DB00204	http://www.drugbank.ca/drugs/DB00204
DrugBank	DB01392	http://www.drugbank.ca/drugs/DB01392
EMBL	AB074970	http://www.ebi.ac.uk/ena/data/view/AB074970
EMBL	AB182123	http://www.ebi.ac.uk/ena/data/view/AB182123
EMBL	AF005214	http://www.ebi.ac.uk/ena/data/view/AF005214
EMBL	BC027982	http://www.ebi.ac.uk/ena/data/view/BC027982
EMBL	L36069	http://www.ebi.ac.uk/ena/data/view/L36069
EMBL	U53143	http://www.ebi.ac.uk/ena/data/view/U53143
Ensembl	ENST00000331718	http://www.ensembl.org/id/ENST00000331718
Ensembl	ENST00000583088	http://www.ensembl.org/id/ENST00000583088
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0031224	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031224
GO_function	GO:0005242	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005242
GO_function	GO:0015467	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015467
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0006936	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006936
GO_process	GO:0008016	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008016
GO_process	GO:0010107	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010107
GO_process	GO:0051289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051289
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.40.1400	http://www.cathdb.info/version/latest/superfamily/2.60.40.1400
GeneCards	KCNJ12	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNJ12
GeneID	3768	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3768
GeneTree	ENSGT00760000118842	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118842
HGNC	HGNC:6258	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6258
HOGENOM	HOG000237325	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237325&db=HOGENOM6
HOVERGEN	HBG006178	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006178&db=HOVERGEN
HPA	HPA027021	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA027021
InParanoid	Q14500	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q14500
InterPro	IPR003272	http://www.ebi.ac.uk/interpro/entry/IPR003272
InterPro	IPR013518	http://www.ebi.ac.uk/interpro/entry/IPR013518
InterPro	IPR013673	http://www.ebi.ac.uk/interpro/entry/IPR013673
InterPro	IPR014756	http://www.ebi.ac.uk/interpro/entry/IPR014756
InterPro	IPR016449	http://www.ebi.ac.uk/interpro/entry/IPR016449
Jabion	3768	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3768
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3768	http://www.genome.jp/dbget-bin/www_bget?hsa:3768
KEGG_Orthology	KO:K05005	http://www.genome.jp/dbget-bin/www_bget?KO:K05005
KEGG_Pathway	ko04725	http://www.genome.jp/kegg-bin/show_pathway?ko04725
MIM	602323	http://www.ncbi.nlm.nih.gov/omim/602323
OMA	TPCVLQV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TPCVLQV
OrthoDB	EOG091G08HC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08HC
PANTHER	PTHR11767	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11767
PANTHER	PTHR11767:SF14	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11767:SF14
PRINTS	PR01320	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01320
PRINTS	PR01325	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01325
PSORT	swissprot:KCJ12_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCJ12_HUMAN
PSORT-B	swissprot:KCJ12_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCJ12_HUMAN
PSORT2	swissprot:KCJ12_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCJ12_HUMAN
Pfam	PF01007	http://pfam.xfam.org/family/PF01007
Pfam	PF08466	http://pfam.xfam.org/family/PF08466
PharmGKB	PA218	http://www.pharmgkb.org/do/serve?objId=PA218&objCls=Gene
Phobius	swissprot:KCJ12_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCJ12_HUMAN
PhylomeDB	Q14500	http://phylomedb.org/?seqid=Q14500
ProteinModelPortal	Q14500	http://www.proteinmodelportal.org/query/uniprot/Q14500
PubMed	12032359	http://www.ncbi.nlm.nih.gov/pubmed/12032359
PubMed	12417321	http://www.ncbi.nlm.nih.gov/pubmed/12417321
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	20921230	http://www.ncbi.nlm.nih.gov/pubmed/20921230
PubMed	7859381	http://www.ncbi.nlm.nih.gov/pubmed/7859381
PubMed	8647284	http://www.ncbi.nlm.nih.gov/pubmed/8647284
PubMed	9430667	http://www.ncbi.nlm.nih.gov/pubmed/9430667
Reactome	R-HSA-1296041	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296041
Reactome	R-HSA-1296053	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296053
Reactome	R-HSA-5576886	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576886
Reactome	R-HSA-997272	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-997272
RefSeq	NP_066292	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_066292
RefSeq	XP_005256682	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005256682
RefSeq	XP_011522133	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011522133
SMR	Q14500	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q14500
STRING	9606.ENSP00000328150	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000328150&targetmode=cogs
SUPFAM	SSF81296	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81296
TCDB	1.A.2.1	http://www.tcdb.org/search/result.php?tc=1.A.2.1
UCSC	uc002gyv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002gyv&org=rat
UniGene	Hs.200629	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.200629
UniProtKB	KCJ12_HUMAN	http://www.uniprot.org/uniprot/KCJ12_HUMAN
UniProtKB-AC	Q14500	http://www.uniprot.org/uniprot/Q14500
charge	swissprot:KCJ12_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCJ12_HUMAN
eggNOG	ENOG410XQ62	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ62
eggNOG	KOG3827	http://eggnogapi.embl.de/nog_data/html/tree/KOG3827
epestfind	swissprot:KCJ12_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCJ12_HUMAN
garnier	swissprot:KCJ12_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCJ12_HUMAN
helixturnhelix	swissprot:KCJ12_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCJ12_HUMAN
hmoment	swissprot:KCJ12_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCJ12_HUMAN
iep	swissprot:KCJ12_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCJ12_HUMAN
inforesidue	swissprot:KCJ12_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCJ12_HUMAN
neXtProt	NX_Q14500	http://www.nextprot.org/db/entry/NX_Q14500
octanol	swissprot:KCJ12_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCJ12_HUMAN
pepcoil	swissprot:KCJ12_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCJ12_HUMAN
pepdigest	swissprot:KCJ12_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCJ12_HUMAN
pepinfo	swissprot:KCJ12_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCJ12_HUMAN
pepnet	swissprot:KCJ12_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCJ12_HUMAN
pepstats	swissprot:KCJ12_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCJ12_HUMAN
pepwheel	swissprot:KCJ12_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCJ12_HUMAN
pepwindow	swissprot:KCJ12_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCJ12_HUMAN
sigcleave	swissprot:KCJ12_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCJ12_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNC2_HUMAN	Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=Kv3.2b; IsoId=Q96PR1-1; Sequence=Displayed; Name=2; Synonyms=Kv3.2d; IsoId=Q96PR1-2; Sequence=VSP_029271; Name=3; Synonyms=Kv3.2a; IsoId=Q96PR1-3; Sequence=VSP_029272; Name=4; Synonyms=Kv3.2c; IsoId=Q96PR1-4; Sequence=VSP_029269, VSP_029270; Name=5; IsoId=Q96PR1-5; Sequence=VSP_044742; Note=No experimental confirmation available.; Name=6; IsoId=Q96PR1-6; Sequence=VSP_046002; Note=No experimental confirmation available.; 
# AltName	Shaw-like potassium channel {ECO:0000250|UniProtKB	P22462}
# AltName	Voltage-gated potassium channel Kv3.2 {ECO:0000250|UniProtKB	P22462}
# BIOPHYSICOCHEMICAL PROPERTIES	KCNC2_HUMAN	Kinetic parameters  Note=Homotetrameric channels expressed in xenopus oocytes or in mammalian non-neuronal cells display delayed-rectifier voltage- dependent potassium currents, that are rapidly activated during membrane depolarization, i.e within a risetime of a few msec. After that, inactivates very slowly, i.e within about >800 msec. Their activation requires a threshold potential at about -10 mV, with a midpoint activation at about 12.1 mV and a steepness parameter of about 8.4 mV. The voltage-dependence of activation and inactivation and other channel characteristics vary depending on the experimental conditions, the expression system, the presence or absence of ancillary subunits and post- translational modifications. {ECO 0000250|UniProtKB P22462, ECO 0000269|PubMed 15709110, ECO 0000305|PubMed 10414303}; 
# CCDS	CCDS58255	-. [Q96PR1-5]
# CCDS	CCDS58256	-. [Q96PR1-2]
# CCDS	CCDS58257	-. [Q96PR1-6]
# CCDS	CCDS9005	-. [Q96PR1-3]
# CCDS	CCDS9006	-. [Q96PR1-4]
# CCDS	CCDS9007	-. [Q96PR1-1]
# DOMAIN	KCNC2_HUMAN	The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. {ECO 0000250|UniProtKB P63142}. 
# DrugBank	DB06637	Dalfampridine
# ENZYME REGULATION	KCNC2_HUMAN	Inhibited by Stichodactyla helianthus peptide ShK (PubMed 15709110). Inhibited by millimolar levels of tetraethylammonium (TEA). Contrary to other channels, inhibited only by millimolar levels of 4-aminopyridine (4-AP) (By similarity). {ECO 0000250|UniProtKB P22462, ECO 0000269|PubMed 15709110, ECO 0000305|PubMed 10414303}. 
# Ensembl	ENST00000298972	ENSP00000298972; ENSG00000166006. [Q96PR1-3]
# Ensembl	ENST00000350228	ENSP00000319877; ENSG00000166006. [Q96PR1-4]
# Ensembl	ENST00000393288	ENSP00000376966; ENSG00000166006. [Q96PR1-6]
# Ensembl	ENST00000540018	ENSP00000438423; ENSG00000166006. [Q96PR1-5]
# Ensembl	ENST00000548513	ENSP00000449941; ENSG00000166006. [Q96PR1-3]
# Ensembl	ENST00000549446	ENSP00000449253; ENSG00000166006. [Q96PR1-1]
# Ensembl	ENST00000550433	ENSP00000448301; ENSG00000166006. [Q96PR1-2]
# ExpressionAtlas	Q96PR1	baseline and differential
# FUNCTION	KCNC2_HUMAN	Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. Homotetramer channels mediate delayed-rectifier voltage-dependent potassium currents that activate rapidly at high-threshold voltages and inactivate slowly. Forms tetrameric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed 15709110). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNC1, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties may be modulated either by the association with ancillary subunits, such as KCNE1, KCNE2 or KCNE3 or indirectly by nitric oxide (NO) through a cGMP- and PKG- mediated signaling cascade, slowing channel activation and deactivation of delayed rectifier potassium channels (By similarity). Contributes to fire sustained trains of very brief action potentials at high frequency in retinal ganglion cells, thalamocortical and suprachiasmatic nucleus (SCN) neurons and in hippocampal and neocortical interneurons (PubMed 15709110). Sustained maximal action potential firing frequency in inhibitory hippocampal interneurons is negatively modulated by histamine H2 receptor activation in a cAMP- and protein kinase (PKA) phosphorylation-dependent manner. Plays a role in maintaining the fidelity of synaptic transmission in neocortical GABAergic interneurons by generating action potential (AP) repolarization at nerve terminals, thus reducing spike-evoked calcium influx and GABA neurotransmitter release. Required for long-range synchronization of gamma oscillations over distance in the neocortex. Contributes to the modulation of the circadian rhythm of spontaneous action potential firing in suprachiasmatic nucleus (SCN) neurons in a light-dependent manner (By similarity). {ECO 0000250|UniProtKB P22462, ECO 0000250|UniProtKB Q14B80, ECO 0000269|PubMed 15709110, ECO 0000305|PubMed 10414303, ECO 0000305|PubMed 11506885}. 
# GO_component	GO:0005622	intracellular; IEA:GOC.
# GO_component	GO:0005886	plasma membrane; ISS:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; ISS:UniProtKB.
# GO_component	GO:0008076	voltage-gated potassium channel complex; ISS:UniProtKB.
# GO_component	GO:0016020	membrane; ISS:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IBA:GO_Central.
# GO_component	GO:0016323	basolateral plasma membrane; ISS:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; ISS:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030424	axon; ISS:UniProtKB.
# GO_component	GO:0030425	dendrite; ISS:UniProtKB.
# GO_component	GO:0030673	axolemma; IEA:Ensembl.
# GO_component	GO:0031982	vesicle; IEA:Ensembl.
# GO_component	GO:0032809	neuronal cell body membrane; ISS:UniProtKB.
# GO_component	GO:0042734	presynaptic membrane; ISS:UniProtKB.
# GO_component	GO:0043195	terminal bouton; IEA:Ensembl.
# GO_component	GO:0043204	perikaryon; ISS:UniProtKB.
# GO_component	GO:0045202	synapse; ISS:UniProtKB.
# GO_component	GO:0045211	postsynaptic membrane; ISS:UniProtKB.
# GO_function	GO:0005249	voltage-gated potassium channel activity; ISS:UniProtKB.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; ISS:UniProtKB.
# GO_process	GO:0009642	response to light intensity; IEA:Ensembl.
# GO_process	GO:0014070	response to organic cyclic compound; IEA:Ensembl.
# GO_process	GO:0014075	response to amine; IEA:Ensembl.
# GO_process	GO:0021759	globus pallidus development; IEA:Ensembl.
# GO_process	GO:0032026	response to magnesium ion; IEA:Ensembl.
# GO_process	GO:0038060	nitric oxide-cGMP-mediated signaling pathway; ISS:UniProtKB.
# GO_process	GO:0045471	response to ethanol; IEA:Ensembl.
# GO_process	GO:0050796	regulation of insulin secretion; TAS:Reactome.
# GO_process	GO:0051260	protein homooligomerization; ISS:UniProtKB.
# GO_process	GO:0051291	protein heterooligomerization; ISS:UniProtKB.
# GO_process	GO:0071242	cellular response to ammonium ion; IEA:Ensembl.
# GO_process	GO:0071732	cellular response to nitric oxide; ISS:UniProtKB.
# GO_process	GO:0071805	potassium ion transmembrane transport; ISS:UniProtKB.
# GO_process	GO:0097237	cellular response to toxic substance; IEA:Ensembl.
# GO_process	GO:1901381	positive regulation of potassium ion transmembrane transport; IEA:Ensembl.
# GO_process	GO:1990089	response to nerve growth factor; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005622	intracellular
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.350	-; 1.
# Genevisible	Q96PR1	HS
# HGNC	HGNC:6234	KCNC2
# InterPro	IPR000210	BTB/POZ_dom
# InterPro	IPR003131	T1-type_BTB
# InterPro	IPR003968	K_chnl_volt-dep_Kv
# InterPro	IPR003974	K_chnl_volt-dep_Kv3
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR011333	SKP1/BTB/POZ
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko04040	Ion channels
# MIM	176256	gene
# Organism	KCNC2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11537	PTHR11537; 2
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01491	KVCHANNEL
# PRINTS	PR01498	SHAWCHANNEL
# PTM	KCNC2_HUMAN	Phosphorylated by PKA in cortical synaptosomes. cAMP- dependent phosphorylation inhibits channel activity (By similarity). Histamine H2 receptor- and PKA-induced phosphorylation extends action potential spike duration, reduces action potential spike amplitude, sustains maximum firing frequency in hippocampal interneurons; also reduces the incidence of high-frequency oscillations in hippocampal CA3 pyramidal cell layers. {ECO 0000250|UniProtKB P22462, ECO 0000250|UniProtKB Q14B80}. 
# Pfam	PF00520	Ion_trans
# Pfam	PF02214	BTB_2
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# Reactome	R-HSA-381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
# RecName	Potassium voltage-gated channel subfamily C member 2 {ECO:0000312|HGNC	HGNC:6234}
# RefSeq	NP_001247426	NM_001260497.1. [Q96PR1-6]
# RefSeq	NP_001247427	NM_001260498.1. [Q96PR1-2]
# RefSeq	NP_001247428	NM_001260499.1. [Q96PR1-5]
# RefSeq	NP_631874	NM_139136.3. [Q96PR1-3]
# RefSeq	NP_631875	NM_139137.3. [Q96PR1-1]
# RefSeq	NP_715624	NM_153748.2. [Q96PR1-4]
# RefSeq	XP_006719445	XM_006719382.3. [Q96PR1-3]
# SEQUENCE CAUTION	Sequence=BAE06076.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.2/KCNC2 sub-subfamily. {ECO	0000305}. 
# SMART	SM00225	BTB
# SUBCELLULAR LOCATION	KCNC2_HUMAN	Cell membrane {ECO 0000269|PubMed 15709110}; Multi-pass membrane protein {ECO 0000255}. Membrane {ECO 0000250|UniProtKB Q14B80}; Multi-pass membrane protein {ECO 0000255}. Perikaryon {ECO 0000250|UniProtKB Q14B80}. Cell projection, axon {ECO 0000250|UniProtKB Q14B80}. Cell projection, dendrite {ECO 0000250|UniProtKB Q14B80}. Cell junction, synapse, postsynaptic cell membrane {ECO 0000250|UniProtKB Q14B80}. Cell junction, synapse, presynaptic cell membrane {ECO 0000250|UniProtKB Q14B80}. Cell junction, synapse, synaptosome {ECO 0000250|UniProtKB P22462}. Cell junction, synapse {ECO 0000250|UniProtKB P22462}. Apical cell membrane {ECO 0000250|UniProtKB P22462}. Basolateral cell membrane {ECO 0000250|UniProtKB P22462}. Note=Colocalizes with parvalbumin in globus pallidus neurons. Localizes in thalamocortical axons and synapses. Localizes on the surface of cell somata, proximal dendrites and axonal membranes. Also detected throughout the neuropil. Localized in starburst cell somata and proximal dendrite processes. Colocalized with GABA in presynaptic terminals. Clustered in patches in somatic and proximal dendritic membrane as well as in axons and presnypatic terminals of GABAergic interneurons; some of these patches are found near postsynaptic sites. {ECO 0000250|UniProtKB P22462, ECO 0000250|UniProtKB Q14B80}. 
# SUBUNIT	KCNC2_HUMAN	Homotetramer and heterotetramer with other channel- forming alpha subunits, such as KCNC1. Interacts with KCNC1. Homotetramer or heterotetramer channel activity is regulated by association with modulating ancillary subunits such as KCNE1, KCNE2 and KCNE3, creating a functionally diverse range of channel complexes. Interacts with KCNE1, KCNE2 and KCNE3. {ECO 0000250|UniProtKB P22462, ECO 0000250|UniProtKB Q14B80}. 
# SUPFAM	SSF54695	SSF54695; 2
# TopDownProteomics	Q96PR1-4	-. [Q96PR1-4]
# UCSC	uc001sxe	human. [Q96PR1-1]
# eggNOG	COG1226	LUCA
# eggNOG	KOG3713	Eukaryota
BLAST	swissprot:KCNC2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNC2_HUMAN
COXPRESdb	3747	http://coxpresdb.jp/data/gene/3747.shtml
CleanEx	HS_KCNC2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNC2
DOI	10.1007/BF00357794	http://dx.doi.org/10.1007/BF00357794
DOI	10.1016/S0166-2236(00)01892-0	http://dx.doi.org/10.1016/S0166-2236(00)01892-0
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1749-6632.1999.tb11295.x	http://dx.doi.org/10.1111/j.1749-6632.1999.tb11295.x
DOI	10.1124/mol.105.011064	http://dx.doi.org/10.1124/mol.105.011064
DrugBank	DB06637	http://www.drugbank.ca/drugs/DB06637
EMBL	AB209994	http://www.ebi.ac.uk/ena/data/view/AB209994
EMBL	AC073525	http://www.ebi.ac.uk/ena/data/view/AC073525
EMBL	AC091534	http://www.ebi.ac.uk/ena/data/view/AC091534
EMBL	AC130405	http://www.ebi.ac.uk/ena/data/view/AC130405
EMBL	AF268896	http://www.ebi.ac.uk/ena/data/view/AF268896
EMBL	AF268897	http://www.ebi.ac.uk/ena/data/view/AF268897
EMBL	AK094720	http://www.ebi.ac.uk/ena/data/view/AK094720
EMBL	AK294269	http://www.ebi.ac.uk/ena/data/view/AK294269
EMBL	AK309245	http://www.ebi.ac.uk/ena/data/view/AK309245
EMBL	AY118169	http://www.ebi.ac.uk/ena/data/view/AY118169
EMBL	AY243473	http://www.ebi.ac.uk/ena/data/view/AY243473
EMBL	BC093635	http://www.ebi.ac.uk/ena/data/view/BC093635
EMBL	BC111991	http://www.ebi.ac.uk/ena/data/view/BC111991
EMBL	CH471054	http://www.ebi.ac.uk/ena/data/view/CH471054
EMBL	CH471054	http://www.ebi.ac.uk/ena/data/view/CH471054
EMBL	CH471054	http://www.ebi.ac.uk/ena/data/view/CH471054
EMBL	CH471054	http://www.ebi.ac.uk/ena/data/view/CH471054
Ensembl	ENST00000298972	http://www.ensembl.org/id/ENST00000298972
Ensembl	ENST00000350228	http://www.ensembl.org/id/ENST00000350228
Ensembl	ENST00000393288	http://www.ensembl.org/id/ENST00000393288
Ensembl	ENST00000540018	http://www.ensembl.org/id/ENST00000540018
Ensembl	ENST00000548513	http://www.ensembl.org/id/ENST00000548513
Ensembl	ENST00000549446	http://www.ensembl.org/id/ENST00000549446
Ensembl	ENST00000550433	http://www.ensembl.org/id/ENST00000550433
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030424	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030424
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0030673	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030673
GO_component	GO:0031982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031982
GO_component	GO:0032809	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032809
GO_component	GO:0042734	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042734
GO_component	GO:0043195	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043195
GO_component	GO:0043204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043204
GO_component	GO:0045202	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045202
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_process	GO:0009642	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009642
GO_process	GO:0014070	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014070
GO_process	GO:0014075	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014075
GO_process	GO:0021759	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021759
GO_process	GO:0032026	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032026
GO_process	GO:0038060	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0038060
GO_process	GO:0045471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045471
GO_process	GO:0050796	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050796
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:0051291	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051291
GO_process	GO:0071242	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071242
GO_process	GO:0071732	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071732
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GO_process	GO:0097237	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097237
GO_process	GO:1901381	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901381
GO_process	GO:1990089	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990089
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	KCNC2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNC2
GeneID	3747	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3747
GeneTree	ENSGT00760000118846	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118846
HGNC	HGNC:6234	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6234
HOGENOM	HOG000231012	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231012&db=HOGENOM6
HOVERGEN	HBG105862	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG105862&db=HOVERGEN
HPA	CAB022571	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB022571
HPA	HPA019664	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA019664
InParanoid	Q96PR1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96PR1
InterPro	IPR000210	http://www.ebi.ac.uk/interpro/entry/IPR000210
InterPro	IPR003131	http://www.ebi.ac.uk/interpro/entry/IPR003131
InterPro	IPR003968	http://www.ebi.ac.uk/interpro/entry/IPR003968
InterPro	IPR003974	http://www.ebi.ac.uk/interpro/entry/IPR003974
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR011333	http://www.ebi.ac.uk/interpro/entry/IPR011333
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	3747	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3747
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3747	http://www.genome.jp/dbget-bin/www_bget?hsa:3747
KEGG_Orthology	KO:K04888	http://www.genome.jp/dbget-bin/www_bget?KO:K04888
MIM	176256	http://www.ncbi.nlm.nih.gov/omim/176256
OMA	NCSSHGG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NCSSHGG
OrthoDB	EOG091G0EJL	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0EJL
PANTHER	PTHR11537	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01491	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01491
PRINTS	PR01498	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01498
PSORT	swissprot:KCNC2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNC2_HUMAN
PSORT-B	swissprot:KCNC2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNC2_HUMAN
PSORT2	swissprot:KCNC2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNC2_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF02214	http://pfam.xfam.org/family/PF02214
PharmGKB	PA35490	http://www.pharmgkb.org/do/serve?objId=PA35490&objCls=Gene
Phobius	swissprot:KCNC2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNC2_HUMAN
PhylomeDB	Q96PR1	http://phylomedb.org/?seqid=Q96PR1
ProteinModelPortal	Q96PR1	http://www.proteinmodelportal.org/query/uniprot/Q96PR1
PubMed	10414303	http://www.ncbi.nlm.nih.gov/pubmed/10414303
PubMed	11506885	http://www.ncbi.nlm.nih.gov/pubmed/11506885
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15709110	http://www.ncbi.nlm.nih.gov/pubmed/15709110
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	8111118	http://www.ncbi.nlm.nih.gov/pubmed/8111118
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
Reactome	R-HSA-381676	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-381676
RefSeq	NP_001247426	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001247426
RefSeq	NP_001247427	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001247427
RefSeq	NP_001247428	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001247428
RefSeq	NP_631874	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_631874
RefSeq	NP_631875	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_631875
RefSeq	NP_715624	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_715624
RefSeq	XP_006719445	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006719445
SMART	SM00225	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225
STRING	9606.ENSP00000449253	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000449253&targetmode=cogs
SUPFAM	SSF54695	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54695
UCSC	uc001sxe	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001sxe&org=rat
UniGene	Hs.27214	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.27214
UniGene	Hs.741918	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.741918
UniProtKB	KCNC2_HUMAN	http://www.uniprot.org/uniprot/KCNC2_HUMAN
UniProtKB-AC	Q96PR1	http://www.uniprot.org/uniprot/Q96PR1
charge	swissprot:KCNC2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNC2_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG3713	http://eggnogapi.embl.de/nog_data/html/tree/KOG3713
epestfind	swissprot:KCNC2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNC2_HUMAN
garnier	swissprot:KCNC2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNC2_HUMAN
helixturnhelix	swissprot:KCNC2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNC2_HUMAN
hmoment	swissprot:KCNC2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNC2_HUMAN
iep	swissprot:KCNC2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNC2_HUMAN
inforesidue	swissprot:KCNC2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNC2_HUMAN
neXtProt	NX_Q96PR1	http://www.nextprot.org/db/entry/NX_Q96PR1
octanol	swissprot:KCNC2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNC2_HUMAN
pepcoil	swissprot:KCNC2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNC2_HUMAN
pepdigest	swissprot:KCNC2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNC2_HUMAN
pepinfo	swissprot:KCNC2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNC2_HUMAN
pepnet	swissprot:KCNC2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNC2_HUMAN
pepstats	swissprot:KCNC2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNC2_HUMAN
pepwheel	swissprot:KCNC2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNC2_HUMAN
pepwindow	swissprot:KCNC2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNC2_HUMAN
sigcleave	swissprot:KCNC2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNC2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SC6A6_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P31641-1; Sequence=Displayed; Name=2; IsoId=P31641-2; Sequence=VSP_044961; Note=No experimental confirmation available.; 
# AltName	SC6A6_HUMAN	Solute carrier family 6 member 6
# BioGrid	112424	7
# CCDS	CCDS33705	-. [P31641-1]
# CCDS	CCDS46765	-. [P31641-2]
# ChiTaRS	SLC6A6	human
# Ensembl	ENST00000621751	ENSP00000482560; ENSG00000131389. [P31641-2]
# Ensembl	ENST00000622186	ENSP00000480890; ENSG00000131389. [P31641-1]
# ExpressionAtlas	P31641	baseline and differential
# FUNCTION	SC6A6_HUMAN	Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake. {ECO 0000269|PubMed 8382624}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; TAS:Reactome.
# GO_function	SC6A6_HUMAN	GO 0005328 neurotransmitter sodium symporter activity; IEA InterPro.
# GO_function	SC6A6_HUMAN	GO 0005369 taurine sodium symporter activity; TAS ProtInc.
# GO_process	GO:0003333	amino acid transmembrane transport; IBA:GO_Central.
# GO_process	GO:0006520	cellular amino acid metabolic process; TAS:ProtInc.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006865	amino acid transport; TAS:Reactome.
# GO_process	GO:0015734	taurine transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006520	cellular amino acid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P31641	HS
# HGNC	HGNC:11052	SLC6A6
# IntAct	P31641	2
# InterPro	IPR000175	Na/ntran_symport
# InterPro	IPR002434	Na/ntran_symport_taurine
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Brite	ko04040	 Ion channels
# MIM	186854	gene
# Organism	SC6A6_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11616	PTHR11616
# PIR	G01426	G01426
# PIR	S29839	S29839
# PIR	S46487	S46487
# PRINTS	PR00176	NANEUSMPORT
# PRINTS	PR01200	TAUTRANSPORT
# PROSITE	PS00610	NA_NEUROTRAN_SYMP_1
# PROSITE	PS00754	NA_NEUROTRAN_SYMP_2
# PROSITE	PS50267	NA_NEUROTRAN_SYMP_3
# PTM	SC6A6_HUMAN	Down-regulated upon Ser-322 phosphorylation. {ECO 0000250}. 
# Pfam	PF00209	SNF
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-352230	Amino acid transport across the plasma membrane
# Reactome	R-HSA-442660	Na+/Cl- dependent neurotransmitter transporters
# RecName	SC6A6_HUMAN	Sodium- and chloride-dependent taurine transporter
# RefSeq	NP_001127839	NM_001134367.3
# RefSeq	NP_001127840	NM_001134368.3. [P31641-2]
# RefSeq	NP_003034	NM_003043.5. [P31641-1]
# RefSeq	XP_011532332	XM_011534030.2. [P31641-1]
# SIMILARITY	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	SC6A6_HUMAN	Cell membrane; Multi-pass membrane protein. 
# TCDB	2.A.22.3:the neurotransmitter	sodium symporter (nss) family
# TISSUE SPECIFICITY	Expressed abundantly in placenta and skeletal muscle, at intermediate levels in heart, brain, lung, kidney and pancreas and at low levels in liver. {ECO:0000269|PubMed	8382624}. 
# UCSC	uc032rfd	human. [P31641-1]
# eggNOG	COG0733	LUCA
# eggNOG	KOG3659	Eukaryota
BLAST	swissprot:SC6A6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SC6A6_HUMAN
BioCyc	ZFISH:ENSG00000131389-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000131389-MONOMER
COXPRESdb	6533	http://coxpresdb.jp/data/gene/6533.shtml
CleanEx	HS_SLC6A6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC6A6
DOI	10.1016/0014-5793(93)80008-I	http://dx.doi.org/10.1016/0014-5793(93)80008-I
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1038/nbt.1532	http://dx.doi.org/10.1038/nbt.1532
DOI	10.1042/bj3000893	http://dx.doi.org/10.1042/bj3000893
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC090941	http://www.ebi.ac.uk/ena/data/view/AC090941
EMBL	AC090952	http://www.ebi.ac.uk/ena/data/view/AC090952
EMBL	AC093496	http://www.ebi.ac.uk/ena/data/view/AC093496
EMBL	AF346763	http://www.ebi.ac.uk/ena/data/view/AF346763
EMBL	BC006252	http://www.ebi.ac.uk/ena/data/view/BC006252
EMBL	BC111489	http://www.ebi.ac.uk/ena/data/view/BC111489
EMBL	BC137128	http://www.ebi.ac.uk/ena/data/view/BC137128
EMBL	BC137129	http://www.ebi.ac.uk/ena/data/view/BC137129
EMBL	CH471055	http://www.ebi.ac.uk/ena/data/view/CH471055
EMBL	U09220	http://www.ebi.ac.uk/ena/data/view/U09220
EMBL	U16120	http://www.ebi.ac.uk/ena/data/view/U16120
EMBL	Z18956	http://www.ebi.ac.uk/ena/data/view/Z18956
Ensembl	ENST00000621751	http://www.ensembl.org/id/ENST00000621751
Ensembl	ENST00000622186	http://www.ensembl.org/id/ENST00000622186
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005328
GO_function	GO:0005369	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005369
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_process	GO:0003333	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003333
GO_process	GO:0006520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GO_process	GO:0015734	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015734
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC6A6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC6A6
GeneID	6533	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6533
GeneTree	ENSGT00760000118857	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118857
HGNC	HGNC:11052	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11052
HOGENOM	HOG000116406	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116406&db=HOGENOM6
HOVERGEN	HBG071421	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG071421&db=HOVERGEN
HPA	HPA015028	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA015028
HPA	HPA016488	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA016488
InParanoid	P31641	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31641
IntAct	P31641	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31641*
InterPro	IPR000175	http://www.ebi.ac.uk/interpro/entry/IPR000175
InterPro	IPR002434	http://www.ebi.ac.uk/interpro/entry/IPR002434
Jabion	6533	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6533
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:6533	http://www.genome.jp/dbget-bin/www_bget?hsa:6533
KEGG_Orthology	KO:K05039	http://www.genome.jp/dbget-bin/www_bget?KO:K05039
MIM	186854	http://www.ncbi.nlm.nih.gov/omim/186854
PANTHER	PTHR11616	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11616
PRINTS	PR00176	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00176
PRINTS	PR01200	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01200
PROSITE	PS00610	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00610
PROSITE	PS00754	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00754
PROSITE	PS50267	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50267
PSORT	swissprot:SC6A6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SC6A6_HUMAN
PSORT-B	swissprot:SC6A6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SC6A6_HUMAN
PSORT2	swissprot:SC6A6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SC6A6_HUMAN
Pfam	PF00209	http://pfam.xfam.org/family/PF00209
PharmGKB	PA35912	http://www.pharmgkb.org/do/serve?objId=PA35912&objCls=Gene
Phobius	swissprot:SC6A6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SC6A6_HUMAN
PhylomeDB	P31641	http://phylomedb.org/?seqid=P31641
ProteinModelPortal	P31641	http://www.proteinmodelportal.org/query/uniprot/P31641
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	19349973	http://www.ncbi.nlm.nih.gov/pubmed/19349973
PubMed	8010975	http://www.ncbi.nlm.nih.gov/pubmed/8010975
PubMed	8382624	http://www.ncbi.nlm.nih.gov/pubmed/8382624
PubMed	8654117	http://www.ncbi.nlm.nih.gov/pubmed/8654117
Reactome	R-HSA-352230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-352230
Reactome	R-HSA-442660	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442660
RefSeq	NP_001127839	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001127839
RefSeq	NP_001127840	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001127840
RefSeq	NP_003034	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003034
RefSeq	XP_011532332	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011532332
STRING	9606.ENSP00000354107	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000354107&targetmode=cogs
TCDB	2.A.22.3	http://www.tcdb.org/search/result.php?tc=2.A.22.3
UCSC	uc032rfd	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc032rfd&org=rat
UniGene	Hs.529488	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.529488
UniProtKB	SC6A6_HUMAN	http://www.uniprot.org/uniprot/SC6A6_HUMAN
UniProtKB-AC	P31641	http://www.uniprot.org/uniprot/P31641
charge	swissprot:SC6A6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SC6A6_HUMAN
eggNOG	COG0733	http://eggnogapi.embl.de/nog_data/html/tree/COG0733
eggNOG	KOG3659	http://eggnogapi.embl.de/nog_data/html/tree/KOG3659
epestfind	swissprot:SC6A6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SC6A6_HUMAN
garnier	swissprot:SC6A6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SC6A6_HUMAN
helixturnhelix	swissprot:SC6A6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SC6A6_HUMAN
hmoment	swissprot:SC6A6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SC6A6_HUMAN
iep	swissprot:SC6A6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SC6A6_HUMAN
inforesidue	swissprot:SC6A6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SC6A6_HUMAN
neXtProt	NX_P31641	http://www.nextprot.org/db/entry/NX_P31641
octanol	swissprot:SC6A6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SC6A6_HUMAN
pepcoil	swissprot:SC6A6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SC6A6_HUMAN
pepdigest	swissprot:SC6A6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SC6A6_HUMAN
pepinfo	swissprot:SC6A6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SC6A6_HUMAN
pepnet	swissprot:SC6A6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SC6A6_HUMAN
pepstats	swissprot:SC6A6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SC6A6_HUMAN
pepwheel	swissprot:SC6A6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SC6A6_HUMAN
pepwindow	swissprot:SC6A6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SC6A6_HUMAN
sigcleave	swissprot:SC6A6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SC6A6_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	4ET_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9NRA8-1; Sequence=Displayed; Name=2; IsoId=Q9NRA8-2; Sequence=VSP_003783, VSP_003784, VSP_047042; Note=No experimental confirmation available.; Name=3; IsoId=Q9NRA8-3; Sequence=VSP_047042; Note=No experimental confirmation available.; 
# AltName	4ET_HUMAN	Eukaryotic translation initiation factor 4E nuclear import factor 1
# BioGrid	121148	45
# CCDS	CCDS13898	-. [Q9NRA8-1]
# CCDS	CCDS54520	-. [Q9NRA8-2]
# Ensembl	ENST00000330125	ENSP00000328103; ENSG00000184708. [Q9NRA8-1]
# Ensembl	ENST00000344710	ENSP00000342927; ENSG00000184708. [Q9NRA8-2]
# Ensembl	ENST00000397525	ENSP00000380659; ENSG00000184708. [Q9NRA8-1]
# ExpressionAtlas	Q9NRA8	baseline and differential
# FUNCTION	4ET_HUMAN	Nucleoplasmic shuttling protein. Mediates the nuclear import of EIF4E by a piggy-back mechanism. 
# GO_component	GO:0000932	cytoplasmic mRNA processing body; IEA:Ensembl.
# GO_component	GO:0005634	nucleus; TAS:ProtInc.
# GO_component	GO:0005737	cytoplasm; TAS:ProtInc.
# GO_component	GO:0005829	cytosol; IEA:Ensembl.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016605	PML body; IEA:UniProtKB-SubCell.
# GO_component	GO:0016607	nuclear speck; IEA:UniProtKB-SubCell.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_function	GO:0003729	mRNA binding; IEA:Ensembl.
# GO_function	GO:0008565	protein transporter activity; TAS:ProtInc.
# GO_function	GO:0044822	poly(A) RNA binding; IDA:UniProtKB.
# GO_process	GO:0017148	negative regulation of translation; IEA:Ensembl.
# GO_process	GO:0019827	stem cell population maintenance; IEA:Ensembl.
# GO_process	GO:0045665	negative regulation of neuron differentiation; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003723	RNA binding
# GOslim_function	GO:0003729	mRNA binding
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q9NRA8	HS
# HGNC	HGNC:16687	EIF4ENIF1
# INTERACTION	4ET_HUMAN	Q9WMX2 - (xeno); NbExp=3; IntAct=EBI-301024, EBI-6863741; P26196 DDX6; NbExp=5; IntAct=EBI-301024, EBI-351257; Q9H4E7 DEF6; NbExp=3; IntAct=EBI-301024, EBI-745369; Q4ZH49 DTX2; NbExp=3; IntAct=EBI-301024, EBI-10192429; Q86UW9 DTX2; NbExp=4; IntAct=EBI-301024, EBI-740376; Q5JVL4 EFHC1; NbExp=6; IntAct=EBI-301024, EBI-743105; P06730 EIF4E; NbExp=9; IntAct=EBI-301024, EBI-73440; O60573 EIF4E2; NbExp=3; IntAct=EBI-301024, EBI-398610; Q9NW38 FANCL; NbExp=3; IntAct=EBI-301024, EBI-2339898; P52597 HNRNPF; NbExp=3; IntAct=EBI-301024, EBI-352986; P08727 KRT19; NbExp=3; IntAct=EBI-301024, EBI-742756; O43482 OIP5; NbExp=3; IntAct=EBI-301024, EBI-536879; Q6DKK2 TTC19; NbExp=3; IntAct=EBI-301024, EBI-948354; P40222 TXLNA; NbExp=3; IntAct=EBI-301024, EBI-359793; 
# IntAct	Q9NRA8	44
# InterPro	IPR018862	eIF4E_binding
# MIM	607445	gene
# Organism	4ET_HUMAN	Homo sapiens (Human)
# Orphanet	619	Primary ovarian failure
# PDB	5ANR	X-ray; 2.10 A; C=199-239
# Pfam	PF10477	EIF4E-T
# Proteomes	UP000005640	Chromosome 22
# RecName	4ET_HUMAN	Eukaryotic translation initiation factor 4E transporter
# RefSeq	NP_001157973	NM_001164501.1. [Q9NRA8-1]
# RefSeq	NP_001157974	NM_001164502.1. [Q9NRA8-2]
# RefSeq	NP_062817	NM_019843.3. [Q9NRA8-1]
# RefSeq	XP_005261743	XM_005261686.2. [Q9NRA8-3]
# RefSeq	XP_005261744	XM_005261687.2. [Q9NRA8-3]
# RefSeq	XP_005261745	XM_005261688.2. [Q9NRA8-3]
# RefSeq	XP_011528582	XM_011530280.1. [Q9NRA8-1]
# RefSeq	XP_011528583	XM_011530281.2. [Q9NRA8-3]
# RefSeq	XP_016884353	XM_017028864.1. [Q9NRA8-1]
# SEQUENCE CAUTION	Sequence=BAB15092.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11194.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SUBCELLULAR LOCATION	4ET_HUMAN	Cytoplasm {ECO 0000269|PubMed 22090346}. Nucleus {ECO 0000269|PubMed 22090346}. Nucleus, PML body {ECO 0000269|PubMed 22090346}. Nucleus speckle {ECO 0000269|PubMed 22090346}. Note=Predominantly cytoplasmic. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Localization to nuclear foci and speckles requires active transcription. 
# SUBUNIT	Interacts with EIF4E. Interacts with importin beta only in the presence of importin alpha, suggesting a direct interaction with importin alpha. Interacts with APOBEC3G in an RNA-dependent manner. {ECO:0000269|PubMed	16699599}. 
# TISSUE SPECIFICITY	4ET_HUMAN	Widely expressed. 
# UCSC	uc003akz	human. [Q9NRA8-1]
# eggNOG	ENOG410IG0J	Eukaryota
# eggNOG	ENOG41110MN	LUCA
BLAST	swissprot:4ET_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:4ET_HUMAN
BioCyc	ZFISH:G66-31626-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31626-MONOMER
COXPRESdb	56478	http://coxpresdb.jp/data/gene/56478.shtml
CleanEx	HS_EIF4ENIF1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_EIF4ENIF1
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr0704130	http://dx.doi.org/10.1021/pr0704130
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/990031	http://dx.doi.org/10.1038/990031
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1091/mbc.E11-05-0415	http://dx.doi.org/10.1091/mbc.E11-05-0415
DOI	10.1093/emboj/19.12.3142	http://dx.doi.org/10.1093/emboj/19.12.3142
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1186/gb-2004-5-10-r84	http://dx.doi.org/10.1186/gb-2004-5-10-r84
DOI	10.1371/journal.ppat.0020041	http://dx.doi.org/10.1371/journal.ppat.0020041
EMBL	AF240775	http://www.ebi.ac.uk/ena/data/view/AF240775
EMBL	AK025254	http://www.ebi.ac.uk/ena/data/view/AK025254
EMBL	AK074768	http://www.ebi.ac.uk/ena/data/view/AK074768
EMBL	AK314636	http://www.ebi.ac.uk/ena/data/view/AK314636
EMBL	AL096701	http://www.ebi.ac.uk/ena/data/view/AL096701
EMBL	BC032941	http://www.ebi.ac.uk/ena/data/view/BC032941
EMBL	BC033028	http://www.ebi.ac.uk/ena/data/view/BC033028
EMBL	CH471095	http://www.ebi.ac.uk/ena/data/view/CH471095
EMBL	CR456386	http://www.ebi.ac.uk/ena/data/view/CR456386
Ensembl	ENST00000330125	http://www.ensembl.org/id/ENST00000330125
Ensembl	ENST00000344710	http://www.ensembl.org/id/ENST00000344710
Ensembl	ENST00000397525	http://www.ensembl.org/id/ENST00000397525
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000932	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000932
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016605
GO_component	GO:0016607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016607
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0003729	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003729
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0044822	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044822
GO_process	GO:0017148	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017148
GO_process	GO:0019827	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019827
GO_process	GO:0045665	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045665
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003723	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723
GOslim_function	GO:0003729	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003729
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	EIF4ENIF1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=EIF4ENIF1
GeneID	56478	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56478
GeneTree	ENSGT00390000012071	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000012071
H-InvDB	HIX0016395	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0016395
HGNC	HGNC:16687	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16687
HOGENOM	HOG000232370	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000232370&db=HOGENOM6
HOVERGEN	HBG023298	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG023298&db=HOVERGEN
HPA	HPA001619	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA001619
HPA	HPA002078	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA002078
InParanoid	Q9NRA8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NRA8
IntAct	Q9NRA8	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NRA8*
InterPro	IPR018862	http://www.ebi.ac.uk/interpro/entry/IPR018862
Jabion	56478	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=56478
KEGG_Gene	hsa:56478	http://www.genome.jp/dbget-bin/www_bget?hsa:56478
MIM	607445	http://www.ncbi.nlm.nih.gov/omim/607445
MINT	MINT-1956064	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1956064
OMA	SMPTKVI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SMPTKVI
Orphanet	619	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=619
OrthoDB	EOG091G04PY	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G04PY
PDB	5ANR	http://www.ebi.ac.uk/pdbe-srv/view/entry/5ANR
PDBsum	5ANR	http://www.ebi.ac.uk/pdbsum/5ANR
PSORT	swissprot:4ET_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:4ET_HUMAN
PSORT-B	swissprot:4ET_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:4ET_HUMAN
PSORT2	swissprot:4ET_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:4ET_HUMAN
Pfam	PF10477	http://pfam.xfam.org/family/PF10477
PharmGKB	PA38410	http://www.pharmgkb.org/do/serve?objId=PA38410&objCls=Gene
Phobius	swissprot:4ET_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:4ET_HUMAN
PhylomeDB	Q9NRA8	http://phylomedb.org/?seqid=Q9NRA8
ProteinModelPortal	Q9NRA8	http://www.proteinmodelportal.org/query/uniprot/Q9NRA8
PubMed	10591208	http://www.ncbi.nlm.nih.gov/pubmed/10591208
PubMed	10856257	http://www.ncbi.nlm.nih.gov/pubmed/10856257
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15461802	http://www.ncbi.nlm.nih.gov/pubmed/15461802
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16699599	http://www.ncbi.nlm.nih.gov/pubmed/16699599
PubMed	18088087	http://www.ncbi.nlm.nih.gov/pubmed/18088087
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	22090346	http://www.ncbi.nlm.nih.gov/pubmed/22090346
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
RefSeq	NP_001157973	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001157973
RefSeq	NP_001157974	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001157974
RefSeq	NP_062817	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_062817
RefSeq	XP_005261743	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005261743
RefSeq	XP_005261744	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005261744
RefSeq	XP_005261745	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005261745
RefSeq	XP_011528582	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011528582
RefSeq	XP_011528583	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011528583
RefSeq	XP_016884353	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016884353
SMR	Q9NRA8	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9NRA8
STRING	9606.ENSP00000328103	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000328103&targetmode=cogs
UCSC	uc003akz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003akz&org=rat
UniGene	Hs.517559	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.517559
UniProtKB	4ET_HUMAN	http://www.uniprot.org/uniprot/4ET_HUMAN
UniProtKB-AC	Q9NRA8	http://www.uniprot.org/uniprot/Q9NRA8
charge	swissprot:4ET_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:4ET_HUMAN
eggNOG	ENOG410IG0J	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IG0J
eggNOG	ENOG41110MN	http://eggnogapi.embl.de/nog_data/html/tree/ENOG41110MN
epestfind	swissprot:4ET_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:4ET_HUMAN
garnier	swissprot:4ET_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:4ET_HUMAN
helixturnhelix	swissprot:4ET_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:4ET_HUMAN
hmoment	swissprot:4ET_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:4ET_HUMAN
iep	swissprot:4ET_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:4ET_HUMAN
inforesidue	swissprot:4ET_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:4ET_HUMAN
neXtProt	NX_Q9NRA8	http://www.nextprot.org/db/entry/NX_Q9NRA8
octanol	swissprot:4ET_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:4ET_HUMAN
pepcoil	swissprot:4ET_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:4ET_HUMAN
pepdigest	swissprot:4ET_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:4ET_HUMAN
pepinfo	swissprot:4ET_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:4ET_HUMAN
pepnet	swissprot:4ET_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:4ET_HUMAN
pepstats	swissprot:4ET_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:4ET_HUMAN
pepwheel	swissprot:4ET_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:4ET_HUMAN
pepwindow	swissprot:4ET_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:4ET_HUMAN
sigcleave	swissprot:4ET_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:4ET_HUMAN
## Database	ID	URL or Descriptions
# AltName	TSNAX_HUMAN	Translin-associated factor X
# BioGrid	113108	99
# ChiTaRS	TSNAX	human
# Ensembl	ENST00000366639	ENSP00000355599; ENSG00000116918
# ExpressionAtlas	Q99598	baseline and differential
# FUNCTION	TSNAX_HUMAN	Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis. {ECO 0000269|PubMed 12036294, ECO 0000269|PubMed 21552258}. 
# GO_component	GO:0005634	nucleus; IBA:GO_Central.
# GO_component	GO:0005794	Golgi apparatus; IEA:UniProtKB-SubCell.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
# GO_function	GO:0003677	DNA binding; TAS:ProtInc.
# GO_function	GO:0008565	protein transporter activity; TAS:ProtInc.
# GO_function	GO:0043565	sequence-specific DNA binding; IEA:InterPro.
# GO_function	GO:0044822	poly(A) RNA binding; IDA:UniProtKB.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0007275	multicellular organism development; IEA:UniProtKB-KW.
# GO_process	GO:0007283	spermatogenesis; IEA:UniProtKB-KW.
# GO_process	GO:0030154	cell differentiation; IEA:UniProtKB-KW.
# GO_process	GO:0031047	gene silencing by RNA; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005829	cytosol
# GOslim_function	GO:0003677	DNA binding
# GOslim_function	GO:0003723	RNA binding
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0048856	anatomical structure development
# Gene3D	1.20.58.190	-; 1.
# Gene3D	1.20.58.200	-; 1.
# Genevisible	Q99598	HS
# HGNC	HGNC:12380	TSNAX
# INTERACTION	TSNAX_HUMAN	Q12904 AIMP1; NbExp=3; IntAct=EBI-742638, EBI-1045802; Q8TDH9 BLOC1S5; NbExp=3; IntAct=EBI-742638, EBI-465861; Q9H257 CARD9; NbExp=5; IntAct=EBI-742638, EBI-751319; O95257 GADD45G; NbExp=3; IntAct=EBI-742638, EBI-448202; Q6P597 KLC3; NbExp=5; IntAct=EBI-742638, EBI-1643885; Q9BRK4 LZTS2; NbExp=5; IntAct=EBI-742638, EBI-741037; Q99081 TCF12; NbExp=3; IntAct=EBI-742638, EBI-722877; Q15631 TSN; NbExp=5; IntAct=EBI-742638, EBI-1044160; 
# IntAct	Q99598	98
# InterPro	IPR002848	Translin_fam
# InterPro	IPR016068	Translin_N
# InterPro	IPR016069	Translin_C
# MIM	602964	gene
# Organism	TSNAX_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10741	PTHR10741
# PDB	3PJA	X-ray; 3.00 A; J/K/L=1-290
# PDB	3QB5	X-ray; 2.95 A; K=1-290
# PTM	TSNAX_HUMAN	Sumoylated with SUMO1. {ECO 0000269|PubMed 15561718}. 
# Pfam	PF01997	Translin
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-426486	Small interfering RNA (siRNA) biogenesis
# RecName	TSNAX_HUMAN	Translin-associated protein X
# RefSeq	NP_005990	NM_005999.2
# SIMILARITY	Belongs to the translin family. {ECO	0000305}.
# SUBCELLULAR LOCATION	TSNAX_HUMAN	Cytoplasm, perinuclear region. Golgi apparatus {ECO 0000250}. Nucleus. Note=Accumulate in the Golgi complex of mid-late pachytene spermatocytes (By similarity). Expressed in the cytoplasm in the presence of TSN. {ECO 0000250}. 
# SUBUNIT	TSNAX_HUMAN	Ring-shaped heterooctamer of six TSN and two TSNAX subunits. Interacts with GOLGA3, TSNAXIP1, SUN1 and AKAP9. Interacts with the homodimeric form of C1D following gamma- radiation. Interacts with TSN and C1D in a mutually exclusive manner. {ECO 0000269|PubMed 11801738, ECO 0000269|PubMed 12036294, ECO 0000269|PubMed 15919079, ECO 0000269|PubMed 21552258, ECO 0000269|PubMed 9013868}. 
# SUPFAM	SSF74784	SSF74784
# UCSC	uc001huw	human
# eggNOG	COG2178	LUCA
# eggNOG	KOG3066	Eukaryota
BLAST	swissprot:TSNAX_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TSNAX_HUMAN
BioCyc	ZFISH:ENSG00000116918-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000116918-MONOMER
COXPRESdb	7257	http://coxpresdb.jp/data/gene/7257.shtml
CleanEx	HS_TSNAX	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TSNAX
DIP	DIP-29463N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29463N
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/geno.2002.6779	http://dx.doi.org/10.1006/geno.2002.6779
DOI	10.1016/S0014-5793(96)01444-5	http://dx.doi.org/10.1016/S0014-5793(96)01444-5
DOI	10.1016/j.febslet.2005.05.007	http://dx.doi.org/10.1016/j.febslet.2005.05.007
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/nsmb.2032	http://dx.doi.org/10.1038/nsmb.2032
DOI	10.1074/jbc.M411718200	http://dx.doi.org/10.1074/jbc.M411718200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF271267	http://www.ebi.ac.uk/ena/data/view/AF271267
EMBL	AF271268	http://www.ebi.ac.uk/ena/data/view/AF271268
EMBL	AF271269	http://www.ebi.ac.uk/ena/data/view/AF271269
EMBL	AK313068	http://www.ebi.ac.uk/ena/data/view/AK313068
EMBL	AL445524	http://www.ebi.ac.uk/ena/data/view/AL445524
EMBL	AL445524	http://www.ebi.ac.uk/ena/data/view/AL445524
EMBL	AL626763	http://www.ebi.ac.uk/ena/data/view/AL626763
EMBL	AL626763	http://www.ebi.ac.uk/ena/data/view/AL626763
EMBL	BC010376	http://www.ebi.ac.uk/ena/data/view/BC010376
EMBL	BC011797	http://www.ebi.ac.uk/ena/data/view/BC011797
EMBL	CH471098	http://www.ebi.ac.uk/ena/data/view/CH471098
EMBL	X95073	http://www.ebi.ac.uk/ena/data/view/X95073
Ensembl	ENST00000366639	http://www.ensembl.org/id/ENST00000366639
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_function	GO:0003677	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0043565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565
GO_function	GO:0044822	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044822
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0007275	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007275
GO_process	GO:0007283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007283
GO_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GO_process	GO:0031047	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031047
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_function	GO:0003677	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_function	GO:0003723	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
Gene3D	1.20.58.190	http://www.cathdb.info/version/latest/superfamily/1.20.58.190
Gene3D	1.20.58.200	http://www.cathdb.info/version/latest/superfamily/1.20.58.200
GeneCards	TSNAX	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TSNAX
GeneID	7257	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7257
GeneTree	ENSGT00390000014716	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000014716
HGNC	HGNC:12380	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:12380
HOGENOM	HOG000008075	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000008075&db=HOGENOM6
HOVERGEN	HBG059067	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG059067&db=HOVERGEN
HPA	CAB034263	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB034263
HPA	HPA031054	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031054
HPA	HPA031055	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031055
InParanoid	Q99598	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q99598
IntAct	Q99598	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q99598*
InterPro	IPR002848	http://www.ebi.ac.uk/interpro/entry/IPR002848
InterPro	IPR016068	http://www.ebi.ac.uk/interpro/entry/IPR016068
InterPro	IPR016069	http://www.ebi.ac.uk/interpro/entry/IPR016069
Jabion	7257	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7257
KEGG_Gene	hsa:7257	http://www.genome.jp/dbget-bin/www_bget?hsa:7257
MIM	602964	http://www.ncbi.nlm.nih.gov/omim/602964
MINT	MINT-1347706	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1347706
OMA	CISSVGN	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CISSVGN
OrthoDB	EOG091G0JHU	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0JHU
PANTHER	PTHR10741	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10741
PDB	3PJA	http://www.ebi.ac.uk/pdbe-srv/view/entry/3PJA
PDB	3QB5	http://www.ebi.ac.uk/pdbe-srv/view/entry/3QB5
PDBsum	3PJA	http://www.ebi.ac.uk/pdbsum/3PJA
PDBsum	3QB5	http://www.ebi.ac.uk/pdbsum/3QB5
PSORT	swissprot:TSNAX_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TSNAX_HUMAN
PSORT-B	swissprot:TSNAX_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TSNAX_HUMAN
PSORT2	swissprot:TSNAX_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TSNAX_HUMAN
Pfam	PF01997	http://pfam.xfam.org/family/PF01997
PharmGKB	PA37048	http://www.pharmgkb.org/do/serve?objId=PA37048&objCls=Gene
Phobius	swissprot:TSNAX_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TSNAX_HUMAN
PhylomeDB	Q99598	http://phylomedb.org/?seqid=Q99598
ProteinModelPortal	Q99598	http://www.proteinmodelportal.org/query/uniprot/Q99598
PubMed	11801738	http://www.ncbi.nlm.nih.gov/pubmed/11801738
PubMed	12036294	http://www.ncbi.nlm.nih.gov/pubmed/12036294
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15561718	http://www.ncbi.nlm.nih.gov/pubmed/15561718
PubMed	15919079	http://www.ncbi.nlm.nih.gov/pubmed/15919079
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21552258	http://www.ncbi.nlm.nih.gov/pubmed/21552258
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	9013868	http://www.ncbi.nlm.nih.gov/pubmed/9013868
Reactome	R-HSA-426486	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-426486
RefSeq	NP_005990	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005990
SMR	Q99598	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q99598
STRING	9606.ENSP00000355599	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000355599&targetmode=cogs
SUPFAM	SSF74784	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF74784
UCSC	uc001huw	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001huw&org=rat
UniGene	Hs.13318	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.13318
UniProtKB	TSNAX_HUMAN	http://www.uniprot.org/uniprot/TSNAX_HUMAN
UniProtKB-AC	Q99598	http://www.uniprot.org/uniprot/Q99598
charge	swissprot:TSNAX_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TSNAX_HUMAN
eggNOG	COG2178	http://eggnogapi.embl.de/nog_data/html/tree/COG2178
eggNOG	KOG3066	http://eggnogapi.embl.de/nog_data/html/tree/KOG3066
epestfind	swissprot:TSNAX_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TSNAX_HUMAN
garnier	swissprot:TSNAX_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TSNAX_HUMAN
helixturnhelix	swissprot:TSNAX_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TSNAX_HUMAN
hmoment	swissprot:TSNAX_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TSNAX_HUMAN
iep	swissprot:TSNAX_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TSNAX_HUMAN
inforesidue	swissprot:TSNAX_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TSNAX_HUMAN
neXtProt	NX_Q99598	http://www.nextprot.org/db/entry/NX_Q99598
octanol	swissprot:TSNAX_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TSNAX_HUMAN
pepcoil	swissprot:TSNAX_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TSNAX_HUMAN
pepdigest	swissprot:TSNAX_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TSNAX_HUMAN
pepinfo	swissprot:TSNAX_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TSNAX_HUMAN
pepnet	swissprot:TSNAX_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TSNAX_HUMAN
pepstats	swissprot:TSNAX_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TSNAX_HUMAN
pepwheel	swissprot:TSNAX_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TSNAX_HUMAN
pepwindow	swissprot:TSNAX_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TSNAX_HUMAN
sigcleave	swissprot:TSNAX_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TSNAX_HUMAN
## Database	ID	URL or Descriptions
# AltName	CYB_HUMAN	Complex III subunit 3
# AltName	CYB_HUMAN	Complex III subunit III
# AltName	CYB_HUMAN	Cytochrome b-c1 complex subunit 3
# AltName	CYB_HUMAN	Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
# BioGrid	110619	10
# CAUTION	The full-length protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools. {ECO:0000250|UniProtKB	P00157}.
# CDD	cd00284	Cytochrome_b_N
# COFACTOR	CYB_HUMAN	Name=heme; Xref=ChEBI CHEBI 30413; Evidence={ECO 0000250|UniProtKB P00157}; Note=Binds 2 heme groups non-covalently. {ECO 0000250|UniProtKB P00157}; 
# DISEASE	CYB_HUMAN	Cardiomyopathy, infantile histiocytoid (CMIH) [MIM 500000]  A heart disease characterized by the presence of pale granular foamy histiocyte-like cells within the myocardium. It usually affects children younger than 2 years of age, with a clear predominance of females over males. Infants present with dysrhythmia or cardiac arrest. The clinical course is usually fulminant, sometimes simulating sudden infant death syndrome. {ECO 0000269|PubMed 10960495}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CYB_HUMAN	Leber hereditary optic neuropathy (LHON) [MIM 535000]  A maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes. {ECO 0000269|PubMed 1732158}. Note=The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. 
# DISEASE	CYB_HUMAN	Note=Defects in MT-CYB are a rare cause of mitochondrial dysfunction underlying different myopathies. They include mitochondrial encephalomyopathy, hypertrophic cardiomyopathy (HCM), and sporadic mitochondrial myopathy (MM). In mitochondrial myopathy, exercise intolerance is the predominant symptom. Additional features include lactic acidosis, muscle weakness and/or myoglobinuria. Defects in MTCYB are also found in cases of exercise intolerance accompanied by deafness, mental retardation, retinitis pigmentosa, cataract, growth retardation, epilepsy (multisystem disorder). {ECO 0000269|PubMed 11047755, ECO 0000269|PubMed 11601507}. 
# Ensembl	ENST00000361789	ENSP00000354554; ENSG00000198727
# ExpressionAtlas	P00156	baseline and differential
# FUNCTION	CYB_HUMAN	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. {ECO 0000250|UniProtKB P00157}. 
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0005750	mitochondrial respiratory chain complex III; NAS:UniProtKB.
# GO_function	GO:0008121	ubiquinol-cytochrome-c reductase activity; NAS:UniProtKB.
# GO_function	GO:0009055	electron carrier activity; IEA:Ensembl.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0001666	response to hypoxia; IEA:Ensembl.
# GO_process	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c; NAS:UniProtKB.
# GO_process	GO:0009408	response to heat; IEA:Ensembl.
# GO_process	GO:0009636	response to toxic substance; IEA:Ensembl.
# GO_process	GO:0031100	animal organ regeneration; IEA:Ensembl.
# GO_process	GO:0033590	response to cobalamin; IEA:Ensembl.
# GO_process	GO:0033762	response to glucagon; IEA:Ensembl.
# GO_process	GO:0042493	response to drug; IEA:Ensembl.
# GO_process	GO:0042538	hyperosmotic salinity response; IEA:Ensembl.
# GO_process	GO:0045471	response to ethanol; IEA:Ensembl.
# GO_process	GO:0046686	response to cadmium ion; IEA:Ensembl.
# GO_process	GO:0046688	response to copper ion; IEA:Ensembl.
# GO_process	GO:0046689	response to mercury ion; IEA:Ensembl.
# GO_process	GO:0051592	response to calcium ion; IEA:Ensembl.
# GO_process	GO:0055093	response to hyperoxia; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# Gene3D	1.20.810.10	-; 1.
# HGNC	HGNC:7427	MT-CYB
# IntAct	P00156	3
# InterPro	IPR005797	Cyt_b/b6_N
# InterPro	IPR005798	Cyt_b/b6_C
# InterPro	IPR016174	Di-haem_cyt_TM
# InterPro	IPR027387	Cytb/b6-like
# InterPro	IPR030689	Cytochrome_b
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Disease	H00068	[Neurodegenerative disease] Leber hereditary optic atrophy (LHON)
# KEGG_Disease	H00473	[Inherited metabolic disease; Mitochondrial disease] GRACILE Syndrome
# KEGG_Disease	H01355	[Inherited metabolic disease; Mitochondrial disease] Kearns-Sayre Syndrome
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko00910	Nitrogen metabolism
# KEGG_Pathway	ko02020	Two-component system
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	500000	phenotype
# MIM	516020	gene
# MIM	535000	phenotype
# MISCELLANEOUS	Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm. {ECO	0000250}. 
# Organism	CYB_HUMAN	Homo sapiens (Human)
# Orphanet	104	Leber hereditary optic neuropathy
# Orphanet	137675	Histiocytoid cardiomyopathy
# Orphanet	1460	Isolated CoQ-cytochrome C reductase deficiency
# PIR	A00151	CBHU
# PIRSF	PIRSF038885	COB
# PROSITE	PS51002	CYTB_NTER
# PROSITE	PS51003	CYTB_CTER
# Pfam	PF00032	Cytochrom_B_C
# Pfam	PF00033	Cytochrome_B
# Proteomes	UP000005640	Mitochondrion
# Reactome	R-HSA-611105	Respiratory electron transport
# RecName	CYB_HUMAN	Cytochrome b
# RefSeq	YP_003024038	NC_012920.1
# SIMILARITY	CYB_HUMAN	Belongs to the cytochrome b family. {ECO 0000255|PROSITE-ProRule PRU00967, ECO 0000255|PROSITE- ProRule PRU00968}. 
# SUBCELLULAR LOCATION	CYB_HUMAN	Mitochondrion inner membrane {ECO 0000250|UniProtKB P00157}; Multi-pass membrane protein {ECO 0000250|UniProtKB P00157}. 
# SUBUNIT	The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer. {ECO	0000250|UniProtKB:P00157}. 
# SUPFAM	SSF81342	SSF81342
# SUPFAM	SSF81648	SSF81648
# eggNOG	COG1290	LUCA
# eggNOG	KOG4663	Eukaryota
BLAST	swissprot:CYB_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CYB_HUMAN
BioCyc	ZFISH:HS00029-MONOMER	http://biocyc.org/getid?id=ZFISH:HS00029-MONOMER
COG	COG1290	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1290
COXPRESdb	4519	http://coxpresdb.jp/data/gene/4519.shtml
DOI	10.1002/ana.10151	http://dx.doi.org/10.1002/ana.10151
DOI	10.1002/ana.1224	http://dx.doi.org/10.1002/ana.1224
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/mcpr.1996.0053	http://dx.doi.org/10.1006/mcpr.1996.0053
DOI	10.1007/BF00206061	http://dx.doi.org/10.1007/BF00206061
DOI	10.1007/BF00711378	http://dx.doi.org/10.1007/BF00711378
DOI	10.1007/s00439-003-0983-8	http://dx.doi.org/10.1007/s00439-003-0983-8
DOI	10.1007/s004390050988	http://dx.doi.org/10.1007/s004390050988
DOI	10.1038/13779	http://dx.doi.org/10.1038/13779
DOI	10.1038/290457a0	http://dx.doi.org/10.1038/290457a0
DOI	10.1038/3108	http://dx.doi.org/10.1038/3108
DOI	10.1038/35047064	http://dx.doi.org/10.1038/35047064
DOI	10.1038/sj.ejhg.5200678	http://dx.doi.org/10.1038/sj.ejhg.5200678
DOI	10.1056/NEJM199909303411404	http://dx.doi.org/10.1056/NEJM199909303411404
DOI	10.1073/pnas.92.2.532	http://dx.doi.org/10.1073/pnas.92.2.532
DOI	10.1086/316900	http://dx.doi.org/10.1086/316900
DOI	10.1086/341358	http://dx.doi.org/10.1086/341358
DOI	10.1186/1471-2156-2-13	http://dx.doi.org/10.1186/1471-2156-2-13
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1203/00006450-200009000-00008	http://dx.doi.org/10.1203/00006450-200009000-00008
DOI	10.1212/WNL.51.5.1444	http://dx.doi.org/10.1212/WNL.51.5.1444
EMBL	AF346963	http://www.ebi.ac.uk/ena/data/view/AF346963
EMBL	AF346964	http://www.ebi.ac.uk/ena/data/view/AF346964
EMBL	AF346965	http://www.ebi.ac.uk/ena/data/view/AF346965
EMBL	AF346966	http://www.ebi.ac.uk/ena/data/view/AF346966
EMBL	AF346967	http://www.ebi.ac.uk/ena/data/view/AF346967
EMBL	AF346968	http://www.ebi.ac.uk/ena/data/view/AF346968
EMBL	AF346969	http://www.ebi.ac.uk/ena/data/view/AF346969
EMBL	AF346970	http://www.ebi.ac.uk/ena/data/view/AF346970
EMBL	AF346971	http://www.ebi.ac.uk/ena/data/view/AF346971
EMBL	AF346972	http://www.ebi.ac.uk/ena/data/view/AF346972
EMBL	AF346973	http://www.ebi.ac.uk/ena/data/view/AF346973
EMBL	AF346974	http://www.ebi.ac.uk/ena/data/view/AF346974
EMBL	AF346975	http://www.ebi.ac.uk/ena/data/view/AF346975
EMBL	AF346976	http://www.ebi.ac.uk/ena/data/view/AF346976
EMBL	AF346977	http://www.ebi.ac.uk/ena/data/view/AF346977
EMBL	AF346978	http://www.ebi.ac.uk/ena/data/view/AF346978
EMBL	AF346979	http://www.ebi.ac.uk/ena/data/view/AF346979
EMBL	AF346980	http://www.ebi.ac.uk/ena/data/view/AF346980
EMBL	AF346981	http://www.ebi.ac.uk/ena/data/view/AF346981
EMBL	AF346982	http://www.ebi.ac.uk/ena/data/view/AF346982
EMBL	AF346983	http://www.ebi.ac.uk/ena/data/view/AF346983
EMBL	AF346984	http://www.ebi.ac.uk/ena/data/view/AF346984
EMBL	AF346985	http://www.ebi.ac.uk/ena/data/view/AF346985
EMBL	AF346986	http://www.ebi.ac.uk/ena/data/view/AF346986
EMBL	AF346987	http://www.ebi.ac.uk/ena/data/view/AF346987
EMBL	AF346988	http://www.ebi.ac.uk/ena/data/view/AF346988
EMBL	AF346989	http://www.ebi.ac.uk/ena/data/view/AF346989
EMBL	AF346990	http://www.ebi.ac.uk/ena/data/view/AF346990
EMBL	AF346991	http://www.ebi.ac.uk/ena/data/view/AF346991
EMBL	AF346992	http://www.ebi.ac.uk/ena/data/view/AF346992
EMBL	AF346993	http://www.ebi.ac.uk/ena/data/view/AF346993
EMBL	AF346994	http://www.ebi.ac.uk/ena/data/view/AF346994
EMBL	AF346995	http://www.ebi.ac.uk/ena/data/view/AF346995
EMBL	AF346996	http://www.ebi.ac.uk/ena/data/view/AF346996
EMBL	AF346997	http://www.ebi.ac.uk/ena/data/view/AF346997
EMBL	AF346998	http://www.ebi.ac.uk/ena/data/view/AF346998
EMBL	AF346999	http://www.ebi.ac.uk/ena/data/view/AF346999
EMBL	AF347000	http://www.ebi.ac.uk/ena/data/view/AF347000
EMBL	AF347001	http://www.ebi.ac.uk/ena/data/view/AF347001
EMBL	AF347002	http://www.ebi.ac.uk/ena/data/view/AF347002
EMBL	AF347003	http://www.ebi.ac.uk/ena/data/view/AF347003
EMBL	AF347004	http://www.ebi.ac.uk/ena/data/view/AF347004
EMBL	AF347005	http://www.ebi.ac.uk/ena/data/view/AF347005
EMBL	AF347006	http://www.ebi.ac.uk/ena/data/view/AF347006
EMBL	AF347007	http://www.ebi.ac.uk/ena/data/view/AF347007
EMBL	AF347008	http://www.ebi.ac.uk/ena/data/view/AF347008
EMBL	AF347009	http://www.ebi.ac.uk/ena/data/view/AF347009
EMBL	AF347010	http://www.ebi.ac.uk/ena/data/view/AF347010
EMBL	AF347011	http://www.ebi.ac.uk/ena/data/view/AF347011
EMBL	AF347012	http://www.ebi.ac.uk/ena/data/view/AF347012
EMBL	AF347013	http://www.ebi.ac.uk/ena/data/view/AF347013
EMBL	AF347014	http://www.ebi.ac.uk/ena/data/view/AF347014
EMBL	AF347015	http://www.ebi.ac.uk/ena/data/view/AF347015
EMBL	AF381981	http://www.ebi.ac.uk/ena/data/view/AF381981
EMBL	AF381982	http://www.ebi.ac.uk/ena/data/view/AF381982
EMBL	AF381983	http://www.ebi.ac.uk/ena/data/view/AF381983
EMBL	AF381984	http://www.ebi.ac.uk/ena/data/view/AF381984
EMBL	AF381985	http://www.ebi.ac.uk/ena/data/view/AF381985
EMBL	AF381986	http://www.ebi.ac.uk/ena/data/view/AF381986
EMBL	AF381987	http://www.ebi.ac.uk/ena/data/view/AF381987
EMBL	AF381988	http://www.ebi.ac.uk/ena/data/view/AF381988
EMBL	AF381989	http://www.ebi.ac.uk/ena/data/view/AF381989
EMBL	AF381990	http://www.ebi.ac.uk/ena/data/view/AF381990
EMBL	AF381991	http://www.ebi.ac.uk/ena/data/view/AF381991
EMBL	AF381992	http://www.ebi.ac.uk/ena/data/view/AF381992
EMBL	AF381993	http://www.ebi.ac.uk/ena/data/view/AF381993
EMBL	AF381994	http://www.ebi.ac.uk/ena/data/view/AF381994
EMBL	AF381995	http://www.ebi.ac.uk/ena/data/view/AF381995
EMBL	AF381996	http://www.ebi.ac.uk/ena/data/view/AF381996
EMBL	AF381997	http://www.ebi.ac.uk/ena/data/view/AF381997
EMBL	AF381998	http://www.ebi.ac.uk/ena/data/view/AF381998
EMBL	AF381999	http://www.ebi.ac.uk/ena/data/view/AF381999
EMBL	AF382000	http://www.ebi.ac.uk/ena/data/view/AF382000
EMBL	AF382001	http://www.ebi.ac.uk/ena/data/view/AF382001
EMBL	AF382002	http://www.ebi.ac.uk/ena/data/view/AF382002
EMBL	AF382003	http://www.ebi.ac.uk/ena/data/view/AF382003
EMBL	AF382004	http://www.ebi.ac.uk/ena/data/view/AF382004
EMBL	AF382005	http://www.ebi.ac.uk/ena/data/view/AF382005
EMBL	AF382006	http://www.ebi.ac.uk/ena/data/view/AF382006
EMBL	AF382007	http://www.ebi.ac.uk/ena/data/view/AF382007
EMBL	AF382008	http://www.ebi.ac.uk/ena/data/view/AF382008
EMBL	AF382009	http://www.ebi.ac.uk/ena/data/view/AF382009
EMBL	AF382010	http://www.ebi.ac.uk/ena/data/view/AF382010
EMBL	AF382011	http://www.ebi.ac.uk/ena/data/view/AF382011
EMBL	AF382012	http://www.ebi.ac.uk/ena/data/view/AF382012
EMBL	AF382013	http://www.ebi.ac.uk/ena/data/view/AF382013
EMBL	AF465942	http://www.ebi.ac.uk/ena/data/view/AF465942
EMBL	AF465945	http://www.ebi.ac.uk/ena/data/view/AF465945
EMBL	AF465946	http://www.ebi.ac.uk/ena/data/view/AF465946
EMBL	AF465947	http://www.ebi.ac.uk/ena/data/view/AF465947
EMBL	AF465948	http://www.ebi.ac.uk/ena/data/view/AF465948
EMBL	AF465949	http://www.ebi.ac.uk/ena/data/view/AF465949
EMBL	AF465953	http://www.ebi.ac.uk/ena/data/view/AF465953
EMBL	AF465956	http://www.ebi.ac.uk/ena/data/view/AF465956
EMBL	AF465968	http://www.ebi.ac.uk/ena/data/view/AF465968
EMBL	AF465971	http://www.ebi.ac.uk/ena/data/view/AF465971
EMBL	AF465972	http://www.ebi.ac.uk/ena/data/view/AF465972
EMBL	AF465973	http://www.ebi.ac.uk/ena/data/view/AF465973
EMBL	AF465974	http://www.ebi.ac.uk/ena/data/view/AF465974
EMBL	AF465975	http://www.ebi.ac.uk/ena/data/view/AF465975
EMBL	AF465977	http://www.ebi.ac.uk/ena/data/view/AF465977
EMBL	D38112	http://www.ebi.ac.uk/ena/data/view/D38112
EMBL	J01415	http://www.ebi.ac.uk/ena/data/view/J01415
EMBL	M28016	http://www.ebi.ac.uk/ena/data/view/M28016
EMBL	U09500	http://www.ebi.ac.uk/ena/data/view/U09500
EMBL	V00662	http://www.ebi.ac.uk/ena/data/view/V00662
Ensembl	ENST00000361789	http://www.ensembl.org/id/ENST00000361789
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005750	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005750
GO_function	GO:0008121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008121
GO_function	GO:0009055	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0001666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001666
GO_process	GO:0006122	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006122
GO_process	GO:0009408	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408
GO_process	GO:0009636	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009636
GO_process	GO:0031100	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031100
GO_process	GO:0033590	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033590
GO_process	GO:0033762	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033762
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0042538	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042538
GO_process	GO:0045471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045471
GO_process	GO:0046686	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046686
GO_process	GO:0046688	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046688
GO_process	GO:0046689	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046689
GO_process	GO:0051592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051592
GO_process	GO:0055093	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055093
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
Gene3D	1.20.810.10	http://www.cathdb.info/version/latest/superfamily/1.20.810.10
GeneCards	MT-CYB	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=MT-CYB
GeneID	4519	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4519
GeneTree	ENSGT00390000017948	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000017948
HGNC	HGNC:7427	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:7427
HOVERGEN	HBG017694	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG017694&db=HOVERGEN
HPA	CAB032215	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB032215
HPA	HPA068400	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA068400
InParanoid	P00156	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00156
IntAct	P00156	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00156*
InterPro	IPR005797	http://www.ebi.ac.uk/interpro/entry/IPR005797
InterPro	IPR005798	http://www.ebi.ac.uk/interpro/entry/IPR005798
InterPro	IPR016174	http://www.ebi.ac.uk/interpro/entry/IPR016174
InterPro	IPR027387	http://www.ebi.ac.uk/interpro/entry/IPR027387
InterPro	IPR030689	http://www.ebi.ac.uk/interpro/entry/IPR030689
Jabion	4519	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=4519
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Disease	H00068	http://www.genome.jp/dbget-bin/www_bget?H00068
KEGG_Disease	H00473	http://www.genome.jp/dbget-bin/www_bget?H00473
KEGG_Disease	H01355	http://www.genome.jp/dbget-bin/www_bget?H01355
KEGG_Gene	hsa:4519	http://www.genome.jp/dbget-bin/www_bget?hsa:4519
KEGG_Orthology	KO:K00412	http://www.genome.jp/dbget-bin/www_bget?KO:K00412
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko00910	http://www.genome.jp/kegg-bin/show_pathway?ko00910
KEGG_Pathway	ko02020	http://www.genome.jp/kegg-bin/show_pathway?ko02020
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	500000	http://www.ncbi.nlm.nih.gov/omim/500000
MIM	516020	http://www.ncbi.nlm.nih.gov/omim/516020
MIM	535000	http://www.ncbi.nlm.nih.gov/omim/535000
OMA	FMDWVDA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FMDWVDA
Orphanet	104	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=104
Orphanet	137675	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=137675
Orphanet	1460	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1460
OrthoDB	EOG091G0DW4	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0DW4
PROSITE	PS51002	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51002
PROSITE	PS51003	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51003
PSORT	swissprot:CYB_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CYB_HUMAN
PSORT-B	swissprot:CYB_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CYB_HUMAN
PSORT2	swissprot:CYB_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CYB_HUMAN
Pfam	PF00032	http://pfam.xfam.org/family/PF00032
Pfam	PF00033	http://pfam.xfam.org/family/PF00033
PharmGKB	PA31234	http://www.pharmgkb.org/do/serve?objId=PA31234&objCls=Gene
Phobius	swissprot:CYB_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CYB_HUMAN
PhylomeDB	P00156	http://phylomedb.org/?seqid=P00156
ProteinModelPortal	P00156	http://www.proteinmodelportal.org/query/uniprot/P00156
PubMed	10453733	http://www.ncbi.nlm.nih.gov/pubmed/10453733
PubMed	10502593	http://www.ncbi.nlm.nih.gov/pubmed/10502593
PubMed	10508508	http://www.ncbi.nlm.nih.gov/pubmed/10508508
PubMed	10960495	http://www.ncbi.nlm.nih.gov/pubmed/10960495
PubMed	11047755	http://www.ncbi.nlm.nih.gov/pubmed/11047755
PubMed	11130070	http://www.ncbi.nlm.nih.gov/pubmed/11130070
PubMed	11464242	http://www.ncbi.nlm.nih.gov/pubmed/11464242
PubMed	11553319	http://www.ncbi.nlm.nih.gov/pubmed/11553319
PubMed	11601507	http://www.ncbi.nlm.nih.gov/pubmed/11601507
PubMed	11891837	http://www.ncbi.nlm.nih.gov/pubmed/11891837
PubMed	12022039	http://www.ncbi.nlm.nih.gov/pubmed/12022039
PubMed	12905068	http://www.ncbi.nlm.nih.gov/pubmed/12905068
PubMed	1732158	http://www.ncbi.nlm.nih.gov/pubmed/1732158
PubMed	1757091	http://www.ncbi.nlm.nih.gov/pubmed/1757091
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	6100559	http://www.ncbi.nlm.nih.gov/pubmed/6100559
PubMed	7219534	http://www.ncbi.nlm.nih.gov/pubmed/7219534
PubMed	7530363	http://www.ncbi.nlm.nih.gov/pubmed/7530363
PubMed	7623448	http://www.ncbi.nlm.nih.gov/pubmed/7623448
PubMed	8910895	http://www.ncbi.nlm.nih.gov/pubmed/8910895
PubMed	9806551	http://www.ncbi.nlm.nih.gov/pubmed/9806551
PubMed	9818877	http://www.ncbi.nlm.nih.gov/pubmed/9818877
Reactome	R-HSA-611105	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-611105
RefSeq	YP_003024038	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_003024038
SMR	P00156	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00156
STRING	9606.ENSP00000354554	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000354554&targetmode=cogs
STRING	COG1290	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1290&targetmode=cogs
SUPFAM	SSF81342	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81342
SUPFAM	SSF81648	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81648
UniProtKB	CYB_HUMAN	http://www.uniprot.org/uniprot/CYB_HUMAN
UniProtKB-AC	P00156	http://www.uniprot.org/uniprot/P00156
charge	swissprot:CYB_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CYB_HUMAN
eggNOG	COG1290	http://eggnogapi.embl.de/nog_data/html/tree/COG1290
eggNOG	KOG4663	http://eggnogapi.embl.de/nog_data/html/tree/KOG4663
epestfind	swissprot:CYB_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CYB_HUMAN
garnier	swissprot:CYB_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CYB_HUMAN
helixturnhelix	swissprot:CYB_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYB_HUMAN
hmoment	swissprot:CYB_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CYB_HUMAN
iep	swissprot:CYB_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CYB_HUMAN
inforesidue	swissprot:CYB_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CYB_HUMAN
neXtProt	NX_P00156	http://www.nextprot.org/db/entry/NX_P00156
octanol	swissprot:CYB_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CYB_HUMAN
pepcoil	swissprot:CYB_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CYB_HUMAN
pepdigest	swissprot:CYB_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CYB_HUMAN
pepinfo	swissprot:CYB_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CYB_HUMAN
pepnet	swissprot:CYB_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CYB_HUMAN
pepstats	swissprot:CYB_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CYB_HUMAN
pepwheel	swissprot:CYB_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CYB_HUMAN
pepwindow	swissprot:CYB_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CYB_HUMAN
sigcleave	swissprot:CYB_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CYB_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	IPO8_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O15397-1; Sequence=Displayed; Name=2; IsoId=O15397-2; Sequence=VSP_042574; Note=No experimental confirmation available.; 
# AltName	IPO8_HUMAN	Ran-binding protein 8
# BioGrid	115781	55
# CCDS	CCDS53773	-. [O15397-2]
# CCDS	CCDS8719	-. [O15397-1]
# Ensembl	ENST00000256079	ENSP00000256079; ENSG00000133704. [O15397-1]
# Ensembl	ENST00000544829	ENSP00000444520; ENSG00000133704. [O15397-2]
# ExpressionAtlas	O15397	baseline and differential
# FUNCTION	IPO8_HUMAN	Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter- like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19. {ECO 0000269|PubMed 11682607, ECO 0000269|PubMed 9214382}. 
# GO_component	GO:0005635	nuclear envelope; IBA:GO_Central.
# GO_component	GO:0005654	nucleoplasm; TAS:Reactome.
# GO_component	GO:0005829	cytosol; IBA:GO_Central.
# GO_function	GO:0008536	Ran GTPase binding; TAS:ProtInc.
# GO_function	GO:0008565	protein transporter activity; IBA:GO_Central.
# GO_process	GO:0006606	protein import into nucleus; IBA:GO_Central.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0031047	gene silencing by RNA; TAS:Reactome.
# GOslim_component	GO:0005635	nuclear envelope
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.25.10.10	-; 2.
# Genevisible	O15397	HS
# HGNC	HGNC:9853	IPO8
# INTERACTION	IPO8_HUMAN	Q9UL18 AGO1; NbExp=2; IntAct=EBI-358808, EBI-527363; Q9UKV8 AGO2; NbExp=4; IntAct=EBI-358808, EBI-528269; Q9H9G7 AGO3; NbExp=5; IntAct=EBI-358808, EBI-2267883; Q9HCK5 AGO4; NbExp=3; IntAct=EBI-358808, EBI-2269696; 
# IntAct	O15397	39
# InterPro	IPR001494	Importin-beta_N
# InterPro	IPR011989	ARM-like
# InterPro	IPR013713	Cse1
# InterPro	IPR016024	ARM-type_fold
# MIM	605600	gene
# Organism	IPO8_HUMAN	Homo sapiens (Human)
# PROSITE	PS50166	IMPORTIN_B_NT
# Pfam	PF03810	IBN_N
# Pfam	PF08506	Cse1
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-5578749	Transcriptional regulation by small RNAs
# RecName	IPO8_HUMAN	Importin-8
# RefSeq	NP_001177924	NM_001190995.1. [O15397-2]
# RefSeq	NP_006381	NM_006390.3. [O15397-1]
# SIMILARITY	Belongs to the importin beta family. {ECO	0000305}. 
# SIMILARITY	Contains 1 importin N-terminal domain. {ECO:0000255|PROSITE-ProRule	PRU00115}.
# SMART	SM00913	IBN_N
# SUBCELLULAR LOCATION	IPO8_HUMAN	Cytoplasm {ECO 0000250}. Nucleus {ECO 0000250}. 
# SUBUNIT	IPO8_HUMAN	Forms a heterodimer with KPNB1. Interacts with SRP19. Binds directly to nuclear pore complexes. {ECO 0000269|PubMed 11682607, ECO 0000269|PubMed 9214382}. 
# SUPFAM	SSF48371	SSF48371
# TCDB	1.I.1.1	the nuclear pore complex (npc) family
# UCSC	uc001rjd	human. [O15397-1]
# eggNOG	COG5656	LUCA
# eggNOG	KOG1991	Eukaryota
BLAST	swissprot:IPO8_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:IPO8_HUMAN
BioCyc	ZFISH:ENSG00000133704-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000133704-MONOMER
COXPRESdb	10526	http://coxpresdb.jp/data/gene/10526.shtml
CleanEx	HS_IPO8	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_IPO8
DIP	DIP-44186N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-44186N
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1083/jcb.138.1.65	http://dx.doi.org/10.1083/jcb.138.1.65
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AC012673	http://www.ebi.ac.uk/ena/data/view/AC012673
EMBL	AC023426	http://www.ebi.ac.uk/ena/data/view/AC023426
EMBL	AK302260	http://www.ebi.ac.uk/ena/data/view/AK302260
EMBL	U77494	http://www.ebi.ac.uk/ena/data/view/U77494
Ensembl	ENST00000256079	http://www.ensembl.org/id/ENST00000256079
Ensembl	ENST00000544829	http://www.ensembl.org/id/ENST00000544829
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_function	GO:0008536	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008536
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0006606	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006606
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0031047	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031047
GOslim_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
GeneCards	IPO8	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=IPO8
GeneID	10526	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10526
GeneTree	ENSGT00550000074736	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074736
HGNC	HGNC:9853	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:9853
HOGENOM	HOG000006586	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006586&db=HOGENOM6
HOVERGEN	HBG006824	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006824&db=HOVERGEN
HPA	HPA018439	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA018439
HPA	HPA023765	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA023765
InParanoid	O15397	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O15397
IntAct	O15397	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O15397*
InterPro	IPR001494	http://www.ebi.ac.uk/interpro/entry/IPR001494
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR013713	http://www.ebi.ac.uk/interpro/entry/IPR013713
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
Jabion	10526	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10526
KEGG_Gene	hsa:10526	http://www.genome.jp/dbget-bin/www_bget?hsa:10526
MIM	605600	http://www.ncbi.nlm.nih.gov/omim/605600
MINT	MINT-1150774	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1150774
OMA	QTQAKEY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QTQAKEY
OrthoDB	EOG091G01IF	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01IF
PROSITE	PS50166	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50166
PSORT	swissprot:IPO8_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:IPO8_HUMAN
PSORT-B	swissprot:IPO8_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:IPO8_HUMAN
PSORT2	swissprot:IPO8_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:IPO8_HUMAN
Pfam	PF03810	http://pfam.xfam.org/family/PF03810
Pfam	PF08506	http://pfam.xfam.org/family/PF08506
PharmGKB	PA34214	http://www.pharmgkb.org/do/serve?objId=PA34214&objCls=Gene
Phobius	swissprot:IPO8_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:IPO8_HUMAN
PhylomeDB	O15397	http://phylomedb.org/?seqid=O15397
ProteinModelPortal	O15397	http://www.proteinmodelportal.org/query/uniprot/O15397
PubMed	11682607	http://www.ncbi.nlm.nih.gov/pubmed/11682607
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	9214382	http://www.ncbi.nlm.nih.gov/pubmed/9214382
Reactome	R-HSA-5578749	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578749
RefSeq	NP_001177924	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001177924
RefSeq	NP_006381	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006381
SMART	SM00913	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00913
STRING	9606.ENSP00000256079	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000256079&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
TCDB	1.I.1.1	http://www.tcdb.org/search/result.php?tc=1.I.1.1
UCSC	uc001rjd	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001rjd&org=rat
UniGene	Hs.505136	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.505136
UniProtKB	IPO8_HUMAN	http://www.uniprot.org/uniprot/IPO8_HUMAN
UniProtKB-AC	O15397	http://www.uniprot.org/uniprot/O15397
charge	swissprot:IPO8_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:IPO8_HUMAN
eggNOG	COG5656	http://eggnogapi.embl.de/nog_data/html/tree/COG5656
eggNOG	KOG1991	http://eggnogapi.embl.de/nog_data/html/tree/KOG1991
epestfind	swissprot:IPO8_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:IPO8_HUMAN
garnier	swissprot:IPO8_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:IPO8_HUMAN
helixturnhelix	swissprot:IPO8_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:IPO8_HUMAN
hmoment	swissprot:IPO8_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:IPO8_HUMAN
iep	swissprot:IPO8_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:IPO8_HUMAN
inforesidue	swissprot:IPO8_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:IPO8_HUMAN
neXtProt	NX_O15397	http://www.nextprot.org/db/entry/NX_O15397
octanol	swissprot:IPO8_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:IPO8_HUMAN
pepcoil	swissprot:IPO8_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:IPO8_HUMAN
pepdigest	swissprot:IPO8_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:IPO8_HUMAN
pepinfo	swissprot:IPO8_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:IPO8_HUMAN
pepnet	swissprot:IPO8_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:IPO8_HUMAN
pepstats	swissprot:IPO8_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:IPO8_HUMAN
pepwheel	swissprot:IPO8_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:IPO8_HUMAN
pepwindow	swissprot:IPO8_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:IPO8_HUMAN
sigcleave	swissprot:IPO8_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:IPO8_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	NPT3_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O00624-1; Sequence=Displayed; Name=2; IsoId=O00624-2; Sequence=VSP_020638; Name=3; IsoId=O00624-3; Sequence=VSP_054712; Note=No experimental confirmation available.; 
# AltName	NPT3_HUMAN	Na(+)/PI cotransporter 3
# AltName	NPT3_HUMAN	Sodium/phosphate cotransporter 3
# AltName	NPT3_HUMAN	Solute carrier family 17 member 2
# BioGrid	115540	51
# CCDS	CCDS4567	-. [O00624-2]
# CCDS	CCDS69060	-. [O00624-3]
# CDD	cd06174	MFS
# Ensembl	ENST00000265425	ENSP00000265425; ENSG00000112337. [O00624-1]
# Ensembl	ENST00000360488	ENSP00000353677; ENSG00000112337. [O00624-2]
# Ensembl	ENST00000377850	ENSP00000367081; ENSG00000112337. [O00624-3]
# ExpressionAtlas	O00624	baseline and differential
# FUNCTION	NPT3_HUMAN	May be involved in actively transporting phosphate into cells via Na(+) cotransport. {ECO 0000250}. 
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_function	GO:0015321	sodium-dependent phosphate transmembrane transporter activity; IBA:GO_Central.
# GO_function	NPT3_HUMAN	GO 0005436 sodium phosphate symporter activity; TAS ProtInc.
# GO_process	GO:0006796	phosphate-containing compound metabolic process; TAS:ProtInc.
# GO_process	GO:0006814	sodium ion transport; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Genevisible	O00624	HS
# HGNC	HGNC:10930	SLC17A2
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	611049	gene
# Organism	NPT3_HUMAN	Homo sapiens (Human)
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 6
# RecName	NPT3_HUMAN	Sodium-dependent phosphate transport protein 3
# RefSeq	NP_001273052	NM_001286123.1. [O00624-3]
# RefSeq	NP_001273054	NM_001286125.1
# RefSeq	NP_005826	NM_005835.3. [O00624-2]
# RefSeq	XP_005248841	XM_005248784.2. [O00624-3]
# RefSeq	XP_006715012	XM_006714949.3. [O00624-3]
# SIMILARITY	Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. {ECO	0000305}.
# SUBCELLULAR LOCATION	NPT3_HUMAN	Membrane; Multi-pass membrane protein. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.1.14.29	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	Expressed in the small intestine, kidney, spleen and testis. Not detected in fetal brain, bone marrow, and mammary gland. {ECO:0000269|PubMed	9149941}. 
# UCSC	uc003nfl	human. [O00624-1]
# eggNOG	ENOG410XPWC	LUCA
# eggNOG	KOG2532	Eukaryota
BLAST	swissprot:NPT3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NPT3_HUMAN
BioCyc	ZFISH:ENSG00000112337-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000112337-MONOMER
COXPRESdb	10246	http://coxpresdb.jp/data/gene/10246.shtml
CleanEx	HS_SLC17A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC17A2
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AL138726	http://www.ebi.ac.uk/ena/data/view/AL138726
EMBL	AL138726	http://www.ebi.ac.uk/ena/data/view/AL138726
EMBL	BC104822	http://www.ebi.ac.uk/ena/data/view/BC104822
EMBL	BC112033	http://www.ebi.ac.uk/ena/data/view/BC112033
EMBL	BC143323	http://www.ebi.ac.uk/ena/data/view/BC143323
EMBL	CH471087	http://www.ebi.ac.uk/ena/data/view/CH471087
EMBL	CH471087	http://www.ebi.ac.uk/ena/data/view/CH471087
EMBL	U90544	http://www.ebi.ac.uk/ena/data/view/U90544
EMBL	U91328	http://www.ebi.ac.uk/ena/data/view/U91328
Ensembl	ENST00000265425	http://www.ensembl.org/id/ENST00000265425
Ensembl	ENST00000360488	http://www.ensembl.org/id/ENST00000360488
Ensembl	ENST00000377850	http://www.ensembl.org/id/ENST00000377850
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0005436	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005436
GO_function	GO:0015321	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015321
GO_process	GO:0006796	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006796
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	SLC17A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC17A2
GeneID	10246	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10246
GeneTree	ENSGT00760000119079	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119079
H-InvDB	HIX0122218	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0122218
HGNC	HGNC:10930	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10930
HOGENOM	HOG000230813	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230813&db=HOGENOM6
HOVERGEN	HBG008834	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG008834&db=HOVERGEN
HPA	HPA038270	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA038270
InParanoid	O00624	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O00624
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	10246	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10246
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:10246	http://www.genome.jp/dbget-bin/www_bget?hsa:10246
KEGG_Orthology	KO:K12300	http://www.genome.jp/dbget-bin/www_bget?KO:K12300
MIM	611049	http://www.ncbi.nlm.nih.gov/omim/611049
OMA	FYIFGST	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FYIFGST
OrthoDB	EOG091G080B	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G080B
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:NPT3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NPT3_HUMAN
PSORT-B	swissprot:NPT3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NPT3_HUMAN
PSORT2	swissprot:NPT3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NPT3_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA35821	http://www.pharmgkb.org/do/serve?objId=PA35821&objCls=Gene
Phobius	swissprot:NPT3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NPT3_HUMAN
PhylomeDB	O00624	http://phylomedb.org/?seqid=O00624
ProteinModelPortal	O00624	http://www.proteinmodelportal.org/query/uniprot/O00624
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	9149941	http://www.ncbi.nlm.nih.gov/pubmed/9149941
RefSeq	NP_001273052	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273052
RefSeq	NP_001273054	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273054
RefSeq	NP_005826	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005826
RefSeq	XP_005248841	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005248841
RefSeq	XP_006715012	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006715012
STRING	9606.ENSP00000353677	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000353677&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.14.29	http://www.tcdb.org/search/result.php?tc=2.A.1.14.29
UCSC	uc003nfl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003nfl&org=rat
UniGene	Hs.591802	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.591802
UniProtKB	NPT3_HUMAN	http://www.uniprot.org/uniprot/NPT3_HUMAN
UniProtKB-AC	O00624	http://www.uniprot.org/uniprot/O00624
charge	swissprot:NPT3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NPT3_HUMAN
eggNOG	ENOG410XPWC	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPWC
eggNOG	KOG2532	http://eggnogapi.embl.de/nog_data/html/tree/KOG2532
epestfind	swissprot:NPT3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NPT3_HUMAN
garnier	swissprot:NPT3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NPT3_HUMAN
helixturnhelix	swissprot:NPT3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NPT3_HUMAN
hmoment	swissprot:NPT3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NPT3_HUMAN
iep	swissprot:NPT3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NPT3_HUMAN
inforesidue	swissprot:NPT3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NPT3_HUMAN
neXtProt	NX_O00624	http://www.nextprot.org/db/entry/NX_O00624
octanol	swissprot:NPT3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NPT3_HUMAN
pepcoil	swissprot:NPT3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NPT3_HUMAN
pepdigest	swissprot:NPT3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NPT3_HUMAN
pepinfo	swissprot:NPT3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NPT3_HUMAN
pepnet	swissprot:NPT3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NPT3_HUMAN
pepstats	swissprot:NPT3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NPT3_HUMAN
pepwheel	swissprot:NPT3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NPT3_HUMAN
pepwindow	swissprot:NPT3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NPT3_HUMAN
sigcleave	swissprot:NPT3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NPT3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CAC1I_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Delta36b; IsoId=Q9P0X4-1; Sequence=Displayed; Name=2; IsoId=Q9P0X4-2; Sequence=VSP_000951; Name=3; Synonyms=Alpha1I-a; IsoId=Q9P0X4-3; Sequence=VSP_000950, VSP_000951; Name=4; IsoId=Q9P0X4-4; Sequence=VSP_000950; 
# AltName	CAC1I_HUMAN	Voltage-gated calcium channel subunit alpha Cav3.3
# CCDS	CCDS46710	-. [Q9P0X4-1]
# CCDS	CCDS46711	-. [Q9P0X4-4]
# ChiTaRS	CACNA1I	human
# DOMAIN	CAC1I_HUMAN	Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position. 
# DrugBank	DB00421	Spironolactone
# DrugBank	DB00568	Cinnarizine
# DrugBank	DB00617	Paramethadione
# DrugBank	DB00661	Verapamil
# DrugBank	DB00909	Zonisamide
# DrugBank	DB04841	Flunarizine
# Ensembl	ENST00000401624	ENSP00000383887; ENSG00000100346. [Q9P0X4-2]
# Ensembl	ENST00000402142	ENSP00000385019; ENSG00000100346. [Q9P0X4-1]
# Ensembl	ENST00000404898	ENSP00000384093; ENSG00000100346. [Q9P0X4-4]
# Ensembl	ENST00000407673	ENSP00000385680; ENSG00000100346. [Q9P0X4-3]
# FUNCTION	CAC1I_HUMAN	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage- dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H (By similarity). {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0005891	voltage-gated calcium channel complex; IEA:InterPro.
# GO_function	GO:0005245	voltage-gated calcium channel activity; TAS:ProtInc.
# GO_function	GO:0008332	low voltage-gated calcium channel activity; IEA:InterPro.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0019228	neuronal action potential; IEA:Ensembl.
# GO_process	GO:0030317	flagellated sperm motility; IEA:InterPro.
# GO_process	GO:0030431	sleep; IEA:Ensembl.
# GO_process	GO:0045956	positive regulation of calcium ion-dependent exocytosis; IBA:GO_Central.
# GO_process	GO:0070509	calcium ion import; IEA:InterPro.
# GO_process	GO:0086010	membrane depolarization during action potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048870	cell motility
# Gene3D	1.20.120.350	-; 4.
# Genevisible	Q9P0X4	HS
# HGNC	HGNC:1396	CACNA1I
# INTERACTION	CAC1I_HUMAN	Q8NEC5 CATSPER1; NbExp=5; IntAct=EBI-1220829, EBI-744545; Q96P56 CATSPER2; NbExp=3; IntAct=EBI-1220829, EBI-2215024; 
# IntAct	Q9P0X4	3
# InterPro	IPR002077	VDCCAlpha1
# InterPro	IPR005445	VDCC_T_a1
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR030162	CACNA1I
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04010	MAPK signaling pathway
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04713	Circadian entrainment
# MIM	608230	gene
# Organism	CAC1I_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10037:SF209	PTHR10037:SF209; 3
# PRINTS	PR00167	CACHANNEL
# PRINTS	PR01629	TVDCCALPHA1
# PTM	CAC1I_HUMAN	In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II. {ECO 0000250}. 
# Pfam	PF00520	Ion_trans; 4
# Proteomes	UP000005640	Chromosome 22
# Reactome	R-HSA-419037	NCAM1 interactions
# RecName	CAC1I_HUMAN	Voltage-dependent T-type calcium channel subunit alpha-1I
# RefSeq	NP_001003406	NM_001003406.1. [Q9P0X4-4]
# RefSeq	NP_066919	NM_021096.3. [Q9P0X4-1]
# SIMILARITY	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1I subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	CAC1I_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Interacts with CATSPER1 and CATSPER2, leading to suppress T-type calcium channel activity. {ECO:0000269|PubMed	16740636}. 
# TCDB	1.A.1.11	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	CAC1I_HUMAN	Brain specific. 
# UCSC	uc003ayc	human. [Q9P0X4-1]
# eggNOG	COG1226	LUCA
# eggNOG	KOG2302	Eukaryota
BLAST	swissprot:CAC1I_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CAC1I_HUMAN
BioCyc	ZFISH:ENSG00000100346-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000100346-MONOMER
COXPRESdb	8911	http://coxpresdb.jp/data/gene/8911.shtml
DOI	10.1016/S0006-3495(02)75164-3	http://dx.doi.org/10.1016/S0006-3495(02)75164-3
DOI	10.1016/S0304-3940(99)00319-5	http://dx.doi.org/10.1016/S0304-3940(99)00319-5
DOI	10.1038/990031	http://dx.doi.org/10.1038/990031
DOI	10.1074/jbc.C000090200	http://dx.doi.org/10.1074/jbc.C000090200
DOI	10.1074/jbc.M511288200	http://dx.doi.org/10.1074/jbc.M511288200
DOI	10.1093/dnares/6.5.329	http://dx.doi.org/10.1093/dnares/6.5.329
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DrugBank	DB00421	http://www.drugbank.ca/drugs/DB00421
DrugBank	DB00568	http://www.drugbank.ca/drugs/DB00568
DrugBank	DB00617	http://www.drugbank.ca/drugs/DB00617
DrugBank	DB00661	http://www.drugbank.ca/drugs/DB00661
DrugBank	DB00909	http://www.drugbank.ca/drugs/DB00909
DrugBank	DB04841	http://www.drugbank.ca/drugs/DB04841
EMBL	AB032946	http://www.ebi.ac.uk/ena/data/view/AB032946
EMBL	AF129133	http://www.ebi.ac.uk/ena/data/view/AF129133
EMBL	AF142567	http://www.ebi.ac.uk/ena/data/view/AF142567
EMBL	AF211189	http://www.ebi.ac.uk/ena/data/view/AF211189
EMBL	AF393329	http://www.ebi.ac.uk/ena/data/view/AF393329
EMBL	AL008716	http://www.ebi.ac.uk/ena/data/view/AL008716
EMBL	AL008716	http://www.ebi.ac.uk/ena/data/view/AL008716
EMBL	AL008716	http://www.ebi.ac.uk/ena/data/view/AL008716
EMBL	AL008716	http://www.ebi.ac.uk/ena/data/view/AL008716
EMBL	AL008716	http://www.ebi.ac.uk/ena/data/view/AL008716
EMBL	AL008716	http://www.ebi.ac.uk/ena/data/view/AL008716
EMBL	AL008716	http://www.ebi.ac.uk/ena/data/view/AL008716
EMBL	AL008716	http://www.ebi.ac.uk/ena/data/view/AL008716
EMBL	AL008716	http://www.ebi.ac.uk/ena/data/view/AL008716
EMBL	AL008716	http://www.ebi.ac.uk/ena/data/view/AL008716
EMBL	AL008716	http://www.ebi.ac.uk/ena/data/view/AL008716
EMBL	AL008716	http://www.ebi.ac.uk/ena/data/view/AL008716
EMBL	AL022312	http://www.ebi.ac.uk/ena/data/view/AL022312
EMBL	AL022312	http://www.ebi.ac.uk/ena/data/view/AL022312
EMBL	AL022312	http://www.ebi.ac.uk/ena/data/view/AL022312
EMBL	AL022312	http://www.ebi.ac.uk/ena/data/view/AL022312
EMBL	AL022312	http://www.ebi.ac.uk/ena/data/view/AL022312
EMBL	AL022312	http://www.ebi.ac.uk/ena/data/view/AL022312
EMBL	AL022312	http://www.ebi.ac.uk/ena/data/view/AL022312
EMBL	AL022312	http://www.ebi.ac.uk/ena/data/view/AL022312
EMBL	AL022312	http://www.ebi.ac.uk/ena/data/view/AL022312
EMBL	AL022312	http://www.ebi.ac.uk/ena/data/view/AL022312
EMBL	AL022312	http://www.ebi.ac.uk/ena/data/view/AL022312
EMBL	AL022312	http://www.ebi.ac.uk/ena/data/view/AL022312
EMBL	AL022319	http://www.ebi.ac.uk/ena/data/view/AL022319
EMBL	AL022319	http://www.ebi.ac.uk/ena/data/view/AL022319
EMBL	AL022319	http://www.ebi.ac.uk/ena/data/view/AL022319
EMBL	AL022319	http://www.ebi.ac.uk/ena/data/view/AL022319
EMBL	AL022319	http://www.ebi.ac.uk/ena/data/view/AL022319
EMBL	AL022319	http://www.ebi.ac.uk/ena/data/view/AL022319
EMBL	AL022319	http://www.ebi.ac.uk/ena/data/view/AL022319
EMBL	AL022319	http://www.ebi.ac.uk/ena/data/view/AL022319
EMBL	AL022319	http://www.ebi.ac.uk/ena/data/view/AL022319
EMBL	AL022319	http://www.ebi.ac.uk/ena/data/view/AL022319
EMBL	AL022319	http://www.ebi.ac.uk/ena/data/view/AL022319
EMBL	AL022319	http://www.ebi.ac.uk/ena/data/view/AL022319
Ensembl	ENST00000401624	http://www.ensembl.org/id/ENST00000401624
Ensembl	ENST00000402142	http://www.ensembl.org/id/ENST00000402142
Ensembl	ENST00000404898	http://www.ensembl.org/id/ENST00000404898
Ensembl	ENST00000407673	http://www.ensembl.org/id/ENST00000407673
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005891
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0008332	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008332
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0019228	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019228
GO_process	GO:0030317	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030317
GO_process	GO:0030431	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030431
GO_process	GO:0045956	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045956
GO_process	GO:0070509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070509
GO_process	GO:0086010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086010
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	CACNA1I	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CACNA1I
GeneID	8911	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8911
GeneTree	ENSGT00830000128242	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00830000128242
HGNC	HGNC:1396	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1396
HOVERGEN	HBG050764	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050764&db=HOVERGEN
InParanoid	Q9P0X4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9P0X4
IntAct	Q9P0X4	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9P0X4*
InterPro	IPR002077	http://www.ebi.ac.uk/interpro/entry/IPR002077
InterPro	IPR005445	http://www.ebi.ac.uk/interpro/entry/IPR005445
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR030162	http://www.ebi.ac.uk/interpro/entry/IPR030162
Jabion	8911	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=8911
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:8911	http://www.genome.jp/dbget-bin/www_bget?hsa:8911
KEGG_Orthology	KO:K04856	http://www.genome.jp/dbget-bin/www_bget?KO:K04856
KEGG_Pathway	ko04010	http://www.genome.jp/kegg-bin/show_pathway?ko04010
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04713	http://www.genome.jp/kegg-bin/show_pathway?ko04713
MIM	608230	http://www.ncbi.nlm.nih.gov/omim/608230
OMA	KMPNIAK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KMPNIAK
OrthoDB	EOG091G02L1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02L1
PANTHER	PTHR10037:SF209	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10037:SF209
PRINTS	PR00167	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00167
PRINTS	PR01629	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01629
PSORT	swissprot:CAC1I_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CAC1I_HUMAN
PSORT-B	swissprot:CAC1I_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CAC1I_HUMAN
PSORT2	swissprot:CAC1I_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CAC1I_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
PharmGKB	PA26011	http://www.pharmgkb.org/do/serve?objId=PA26011&objCls=Gene
Phobius	swissprot:CAC1I_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CAC1I_HUMAN
PhylomeDB	Q9P0X4	http://phylomedb.org/?seqid=Q9P0X4
ProteinModelPortal	Q9P0X4	http://www.proteinmodelportal.org/query/uniprot/Q9P0X4
PubMed	10454147	http://www.ncbi.nlm.nih.gov/pubmed/10454147
PubMed	10574461	http://www.ncbi.nlm.nih.gov/pubmed/10574461
PubMed	10591208	http://www.ncbi.nlm.nih.gov/pubmed/10591208
PubMed	10749850	http://www.ncbi.nlm.nih.gov/pubmed/10749850
PubMed	12080115	http://www.ncbi.nlm.nih.gov/pubmed/12080115
PubMed	16740636	http://www.ncbi.nlm.nih.gov/pubmed/16740636
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
Reactome	R-HSA-419037	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-419037
RefSeq	NP_001003406	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001003406
RefSeq	NP_066919	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_066919
STRING	9606.ENSP00000385019	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000385019&targetmode=cogs
TCDB	1.A.1.11	http://www.tcdb.org/search/result.php?tc=1.A.1.11
UCSC	uc003ayc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ayc&org=rat
UniGene	Hs.125116	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.125116
UniProtKB	CAC1I_HUMAN	http://www.uniprot.org/uniprot/CAC1I_HUMAN
UniProtKB-AC	Q9P0X4	http://www.uniprot.org/uniprot/Q9P0X4
charge	swissprot:CAC1I_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CAC1I_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG2302	http://eggnogapi.embl.de/nog_data/html/tree/KOG2302
epestfind	swissprot:CAC1I_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CAC1I_HUMAN
garnier	swissprot:CAC1I_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CAC1I_HUMAN
helixturnhelix	swissprot:CAC1I_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CAC1I_HUMAN
hmoment	swissprot:CAC1I_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CAC1I_HUMAN
iep	swissprot:CAC1I_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CAC1I_HUMAN
inforesidue	swissprot:CAC1I_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CAC1I_HUMAN
neXtProt	NX_Q9P0X4	http://www.nextprot.org/db/entry/NX_Q9P0X4
octanol	swissprot:CAC1I_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CAC1I_HUMAN
pepcoil	swissprot:CAC1I_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CAC1I_HUMAN
pepdigest	swissprot:CAC1I_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CAC1I_HUMAN
pepinfo	swissprot:CAC1I_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CAC1I_HUMAN
pepnet	swissprot:CAC1I_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CAC1I_HUMAN
pepstats	swissprot:CAC1I_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CAC1I_HUMAN
pepwheel	swissprot:CAC1I_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CAC1I_HUMAN
pepwindow	swissprot:CAC1I_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CAC1I_HUMAN
sigcleave	swissprot:CAC1I_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CAC1I_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	NDUF6_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q330K2-1; Sequence=Displayed; Name=2; IsoId=Q330K2-2; Sequence=VSP_026230; Name=3; IsoId=Q330K2-3; Sequence=VSP_026231, VSP_026232; 
# AltName	NDUF6_HUMAN	Putative phytoene synthase
# CCDS	CCDS6266	-. [Q330K2-1]
# DISEASE	NDUF6_HUMAN	Mitochondrial complex I deficiency (MT-C1D) [MIM 252010]  A disorder of the mitochondrial respiratory chain that causes a wide range of clinical manifestations from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. {ECO 0000269|PubMed 18614015, ECO 0000269|PubMed 26741492}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000396124	ENSP00000379430; ENSG00000156170. [Q330K2-1]
# Ensembl	ENST00000518258	ENSP00000428788; ENSG00000156170. [Q330K2-3]
# Ensembl	ENST00000523337	ENSP00000429038; ENSG00000156170. [Q330K2-3]
# ExpressionAtlas	Q330K2	baseline and differential
# FUNCTION	NDUF6_HUMAN	Involved in the assembly of mitochondrial NADH ubiquinone oxidoreductase complex (complex I) at early stages. May play a role in the biogenesis of MT-ND1. {ECO 0000269|PubMed 18614015, ECO 0000269|PubMed 22019594}. 
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IBA:GO_Central.
# GO_function	GO:0016740	transferase activity; IEA:InterPro.
# GO_function	GO:0022857	transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0009058	biosynthetic process; IEA:InterPro.
# GO_process	GO:0032981	mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005737	cytoplasm
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0009058	biosynthetic process
# Gene3D	1.10.600.10	-; 1.
# Genevisible	Q330K2	HS
# HGNC	HGNC:28625	NDUFAF6
# InterPro	IPR002060	Squ/phyt_synthse
# InterPro	IPR008949	Isoprenoid_synthase_dom
# KEGG_Disease	H00473	[Inherited metabolic disease; Mitochondrial disease] GRACILE Syndrome
# KEGG_Disease	H01354	[Inherited metabolic disease; Neurodegenerative disease; Mitochondrial disease] X-linked Leigh syndrome
# MIM	252010	phenotype
# MIM	612392	gene
# Organism	NDUF6_HUMAN	Homo sapiens (Human)
# Orphanet	255241	Leigh syndrome with leukodystrophy
# Pfam	PF00494	SQS_PSY
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-6799198	Complex I biogenesis
# RecName	NDUF6_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
# RefSeq	NP_001317511	NM_001330582.1
# RefSeq	NP_689629	NM_152416.3. [Q330K2-1]
# RefSeq	XP_011515135	XM_011516833.2. [Q330K2-2]
# RefSeq	XP_011515136	XM_011516834.2. [Q330K2-2]
# RefSeq	XP_011515137	XM_011516835.2. [Q330K2-2]
# RefSeq	XP_011515138	XM_011516836.2. [Q330K2-2]
# RefSeq	XP_011515139	XM_011516837.2. [Q330K2-2]
# RefSeq	XP_011515140	XM_011516838.2. [Q330K2-2]
# RefSeq	XP_011515141	XM_011516839.2. [Q330K2-2]
# RefSeq	XP_011515142	XM_011516840.2. [Q330K2-2]
# RefSeq	XP_011515143	XM_011516841.2. [Q330K2-2]
# RefSeq	XP_011515144	XM_011516842.2. [Q330K2-2]
# RefSeq	XP_016868516	XM_017013027.1. [Q330K2-2]
# RefSeq	XP_016868517	XM_017013028.1. [Q330K2-2]
# RefSeq	XP_016868518	XM_017013029.1. [Q330K2-2]
# RefSeq	XP_016868519	XM_017013030.1. [Q330K2-2]
# RefSeq	XP_016868520	XM_017013031.1
# RefSeq	XP_016868521	XM_017013032.1
# RefSeq	XP_016868522	XM_017013033.1
# SEQUENCE CAUTION	Sequence=BAG60807.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW91734.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the NDUFAF6 family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	NDUF6_HUMAN	Isoform 1  Mitochondrion inner membrane. Note=Peripherally localized on the matrix face of the mitochondrial inner membrane. 
# SUBCELLULAR LOCATION	NDUF6_HUMAN	Isoform 2  Cytoplasm. Nucleus. 
# SUPFAM	SSF48576	SSF48576
# UCSC	uc003yhj	human. [Q330K2-1]
# eggNOG	COG1562	LUCA
# eggNOG	KOG4411	Eukaryota
BLAST	swissprot:NDUF6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NDUF6_HUMAN
BioCyc	ZFISH:HS14605-MONOMER	http://biocyc.org/getid?id=ZFISH:HS14605-MONOMER
COXPRESdb	137682	http://coxpresdb.jp/data/gene/137682.shtml
CleanEx	HS_C8orf38	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_C8orf38
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.cell.2008.06.016	http://dx.doi.org/10.1016/j.cell.2008.06.016
DOI	10.1016/j.jmb.2011.10.012	http://dx.doi.org/10.1016/j.jmb.2011.10.012
DOI	10.1038/nature04406	http://dx.doi.org/10.1038/nature04406
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1371/journal.pgen.1005679	http://dx.doi.org/10.1371/journal.pgen.1005679
EMBL	AC087752	http://www.ebi.ac.uk/ena/data/view/AC087752
EMBL	AK298631	http://www.ebi.ac.uk/ena/data/view/AK298631
EMBL	AY444560	http://www.ebi.ac.uk/ena/data/view/AY444560
EMBL	BC028166	http://www.ebi.ac.uk/ena/data/view/BC028166
EMBL	CH471060	http://www.ebi.ac.uk/ena/data/view/CH471060
Ensembl	ENST00000396124	http://www.ensembl.org/id/ENST00000396124
Ensembl	ENST00000518258	http://www.ensembl.org/id/ENST00000518258
Ensembl	ENST00000523337	http://www.ensembl.org/id/ENST00000523337
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0016740	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016740
GO_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GO_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GO_process	GO:0032981	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032981
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
Gene3D	1.10.600.10	http://www.cathdb.info/version/latest/superfamily/1.10.600.10
GeneCards	NDUFAF6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=NDUFAF6
GeneID	137682	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=137682
GeneTree	ENSGT00510000048688	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00510000048688
HGNC	HGNC:28625	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:28625
HOGENOM	HOG000146031	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000146031&db=HOGENOM6
HOVERGEN	HBG080309	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG080309&db=HOVERGEN
HPA	HPA047148	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA047148
HPA	HPA050545	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA050545
InParanoid	Q330K2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q330K2
InterPro	IPR002060	http://www.ebi.ac.uk/interpro/entry/IPR002060
InterPro	IPR008949	http://www.ebi.ac.uk/interpro/entry/IPR008949
Jabion	137682	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=137682
KEGG_Disease	H00473	http://www.genome.jp/dbget-bin/www_bget?H00473
KEGG_Disease	H01354	http://www.genome.jp/dbget-bin/www_bget?H01354
KEGG_Gene	hsa:137682	http://www.genome.jp/dbget-bin/www_bget?hsa:137682
MIM	252010	http://www.ncbi.nlm.nih.gov/omim/252010
MIM	612392	http://www.ncbi.nlm.nih.gov/omim/612392
OMA	ALPYHAS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ALPYHAS
Orphanet	255241	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=255241
OrthoDB	EOG091G0H0S	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0H0S
PSORT	swissprot:NDUF6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NDUF6_HUMAN
PSORT-B	swissprot:NDUF6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NDUF6_HUMAN
PSORT2	swissprot:NDUF6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NDUF6_HUMAN
Pfam	PF00494	http://pfam.xfam.org/family/PF00494
PharmGKB	PA142672357	http://www.pharmgkb.org/do/serve?objId=PA142672357&objCls=Gene
Phobius	swissprot:NDUF6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NDUF6_HUMAN
PhylomeDB	Q330K2	http://phylomedb.org/?seqid=Q330K2
ProteinModelPortal	Q330K2	http://www.proteinmodelportal.org/query/uniprot/Q330K2
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16421571	http://www.ncbi.nlm.nih.gov/pubmed/16421571
PubMed	18614015	http://www.ncbi.nlm.nih.gov/pubmed/18614015
PubMed	22019594	http://www.ncbi.nlm.nih.gov/pubmed/22019594
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	26741492	http://www.ncbi.nlm.nih.gov/pubmed/26741492
Reactome	R-HSA-6799198	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6799198
RefSeq	NP_001317511	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001317511
RefSeq	NP_689629	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_689629
RefSeq	XP_011515135	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011515135
RefSeq	XP_011515136	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011515136
RefSeq	XP_011515137	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011515137
RefSeq	XP_011515138	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011515138
RefSeq	XP_011515139	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011515139
RefSeq	XP_011515140	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011515140
RefSeq	XP_011515141	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011515141
RefSeq	XP_011515142	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011515142
RefSeq	XP_011515143	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011515143
RefSeq	XP_011515144	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011515144
RefSeq	XP_016868516	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016868516
RefSeq	XP_016868517	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016868517
RefSeq	XP_016868518	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016868518
RefSeq	XP_016868519	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016868519
RefSeq	XP_016868520	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016868520
RefSeq	XP_016868521	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016868521
RefSeq	XP_016868522	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016868522
SMR	Q330K2	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q330K2
STRING	9606.ENSP00000379430	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000379430&targetmode=cogs
SUPFAM	SSF48576	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48576
UCSC	uc003yhj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003yhj&org=rat
UniGene	Hs.729144	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.729144
UniProtKB	NDUF6_HUMAN	http://www.uniprot.org/uniprot/NDUF6_HUMAN
UniProtKB-AC	Q330K2	http://www.uniprot.org/uniprot/Q330K2
charge	swissprot:NDUF6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NDUF6_HUMAN
eggNOG	COG1562	http://eggnogapi.embl.de/nog_data/html/tree/COG1562
eggNOG	KOG4411	http://eggnogapi.embl.de/nog_data/html/tree/KOG4411
epestfind	swissprot:NDUF6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NDUF6_HUMAN
garnier	swissprot:NDUF6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NDUF6_HUMAN
helixturnhelix	swissprot:NDUF6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NDUF6_HUMAN
hmoment	swissprot:NDUF6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NDUF6_HUMAN
iep	swissprot:NDUF6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NDUF6_HUMAN
inforesidue	swissprot:NDUF6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NDUF6_HUMAN
neXtProt	NX_Q330K2	http://www.nextprot.org/db/entry/NX_Q330K2
octanol	swissprot:NDUF6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NDUF6_HUMAN
pepcoil	swissprot:NDUF6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NDUF6_HUMAN
pepdigest	swissprot:NDUF6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NDUF6_HUMAN
pepinfo	swissprot:NDUF6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NDUF6_HUMAN
pepnet	swissprot:NDUF6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NDUF6_HUMAN
pepstats	swissprot:NDUF6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NDUF6_HUMAN
pepwheel	swissprot:NDUF6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NDUF6_HUMAN
pepwindow	swissprot:NDUF6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NDUF6_HUMAN
sigcleave	swissprot:NDUF6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NDUF6_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNH5_HUMAN	Event=Alternative splicing; Named isoforms=3; Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=Q8NCM2-1; Sequence=Displayed; Name=2; Synonyms=2b; IsoId=Q8NCM2-2; Sequence=VSP_000973, VSP_000974; Name=3; IsoId=Q8NCM2-3; Sequence=VSP_000972, VSP_000975, VSP_000976; 
# AltName	KCNH5_HUMAN	Ether-a-go-go potassium channel 2
# AltName	KCNH5_HUMAN	Voltage-gated potassium channel subunit Kv10.2
# CCDS	CCDS45122	-. [Q8NCM2-2]
# CCDS	CCDS9756	-. [Q8NCM2-1]
# DOMAIN	KCNH5_HUMAN	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. 
# Ensembl	ENST00000322893	ENSP00000321427; ENSG00000140015. [Q8NCM2-1]
# Ensembl	ENST00000394968	ENSP00000378419; ENSG00000140015. [Q8NCM2-3]
# Ensembl	ENST00000420622	ENSP00000395439; ENSG00000140015. [Q8NCM2-2]
# FUNCTION	KCNH5_HUMAN	Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly. 
# GO_component	GO:0005622	intracellular; IDA:MGI.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0009986	cell surface; IDA:MGI.
# GO_function	GO:0000155	phosphorelay sensor kinase activity; IEA:InterPro.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IBA:GO_Central.
# GO_process	GO:0010389	regulation of G2/M transition of mitotic cell cycle; IDA:MGI.
# GO_process	GO:0042391	regulation of membrane potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005622	intracellular
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0016301	kinase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# Gene3D	2.60.120.10	-; 1.
# Genevisible	Q8NCM2	HS
# HGNC	HGNC:6254	KCNH5
# InterPro	IPR000014	PAS
# InterPro	IPR000595	cNMP-bd_dom
# InterPro	IPR000700	PAS-assoc_C
# InterPro	IPR001610	PAC
# InterPro	IPR003938	K_chnl_volt-dep_EAG/ELK/ERG
# InterPro	IPR003949	K_chnl_volt-dep_EAG
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR014710	RmlC-like_jellyroll
# InterPro	IPR018490	cNMP-bd-like
# KEGG_Brite	ko04040	Ion channels
# MIM	605716	gene
# Organism	KCNH5_HUMAN	Homo sapiens (Human)
# PRINTS	PR01463	EAGCHANLFMLY
# PRINTS	PR01464	EAGCHANNEL
# PROSITE	PS50042	CNMP_BINDING_3
# PROSITE	PS50113	PAC
# Pfam	PF00027	cNMP_binding
# Pfam	PF00520	Ion_trans
# Pfam	PF13426	PAS_9
# Proteomes	UP000005640	Chromosome 14
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# RecName	KCNH5_HUMAN	Potassium voltage-gated channel subfamily H member 5
# RefSeq	NP_647479	NM_139318.4. [Q8NCM2-1]
# RefSeq	NP_758963	NM_172375.2. [Q8NCM2-2]
# SEQUENCE CAUTION	Sequence=BAC11016.1; Type=Erroneous termination; Positions=436; Note=Translated as Gly.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv10.2/KCNH5 sub-subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 PAC (PAS-associated C-terminal) domain. {ECO:0000255|PROSITE-ProRule	PRU00141}. 
# SIMILARITY	Contains 1 PAS (PER-ARNT-SIM) domain. {ECO	0000305}. 
# SIMILARITY	Contains 1 cyclic nucleotide-binding domain. {ECO:0000255|PROSITE-ProRule	PRU00060}. 
# SMART	SM00086	PAC
# SMART	SM00100	cNMP
# SUBCELLULAR LOCATION	KCNH5_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH1/EAG (Probable). {ECO	0000305}. 
# SUPFAM	SSF51206	SSF51206
# SUPFAM	SSF55785	SSF55785
# TIGRFAMs	TIGR00229	sensory_box
# TISSUE SPECIFICITY	KCNH5_HUMAN	Detected in brain, skeletal muscle, heart, placenta, lung and liver, and at low levels in kidney. 
# UCSC	uc001xfx	human. [Q8NCM2-1]
# eggNOG	ENOG410XPSE	LUCA
# eggNOG	KOG0498	Eukaryota
BLAST	swissprot:KCNH5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNH5_HUMAN
BioCyc	ZFISH:ENSG00000140015-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000140015-MONOMER
COXPRESdb	27133	http://coxpresdb.jp/data/gene/27133.shtml
CleanEx	HS_KCNH5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNH5
DOI	10.1002/pmic.200700887	http://dx.doi.org/10.1002/pmic.200700887
DOI	10.1016/S0014-5793(02)02365-7	http://dx.doi.org/10.1016/S0014-5793(02)02365-7
DOI	10.1016/S0014-5793(02)03055-7	http://dx.doi.org/10.1016/S0014-5793(02)03055-7
DOI	10.1038/nature01348	http://dx.doi.org/10.1038/nature01348
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF418206	http://www.ebi.ac.uk/ena/data/view/AF418206
EMBL	AF472412	http://www.ebi.ac.uk/ena/data/view/AF472412
EMBL	AF493798	http://www.ebi.ac.uk/ena/data/view/AF493798
EMBL	AK074484	http://www.ebi.ac.uk/ena/data/view/AK074484
EMBL	AL109985	http://www.ebi.ac.uk/ena/data/view/AL109985
EMBL	AL132666	http://www.ebi.ac.uk/ena/data/view/AL132666
EMBL	AL137191	http://www.ebi.ac.uk/ena/data/view/AL137191
EMBL	AL355101	http://www.ebi.ac.uk/ena/data/view/AL355101
EMBL	BC073979	http://www.ebi.ac.uk/ena/data/view/BC073979
EMBL	CH471061	http://www.ebi.ac.uk/ena/data/view/CH471061
Ensembl	ENST00000322893	http://www.ensembl.org/id/ENST00000322893
Ensembl	ENST00000394968	http://www.ensembl.org/id/ENST00000394968
Ensembl	ENST00000420622	http://www.ensembl.org/id/ENST00000420622
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_function	GO:0000155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_process	GO:0010389	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010389
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0016301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	2.60.120.10	http://www.cathdb.info/version/latest/superfamily/2.60.120.10
GeneCards	KCNH5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNH5
GeneID	27133	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27133
GeneTree	ENSGT00760000118772	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118772
HGNC	HGNC:6254	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6254
HOGENOM	HOG000230794	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230794&db=HOGENOM6
HOVERGEN	HBG101348	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG101348&db=HOVERGEN
HPA	HPA030487	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA030487
InParanoid	Q8NCM2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8NCM2
InterPro	IPR000014	http://www.ebi.ac.uk/interpro/entry/IPR000014
InterPro	IPR000595	http://www.ebi.ac.uk/interpro/entry/IPR000595
InterPro	IPR000700	http://www.ebi.ac.uk/interpro/entry/IPR000700
InterPro	IPR001610	http://www.ebi.ac.uk/interpro/entry/IPR001610
InterPro	IPR003938	http://www.ebi.ac.uk/interpro/entry/IPR003938
InterPro	IPR003949	http://www.ebi.ac.uk/interpro/entry/IPR003949
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR014710	http://www.ebi.ac.uk/interpro/entry/IPR014710
InterPro	IPR018490	http://www.ebi.ac.uk/interpro/entry/IPR018490
Jabion	27133	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=27133
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:27133	http://www.genome.jp/dbget-bin/www_bget?hsa:27133
KEGG_Orthology	KO:K04908	http://www.genome.jp/dbget-bin/www_bget?KO:K04908
MIM	605716	http://www.ncbi.nlm.nih.gov/omim/605716
OMA	NKAEVVH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NKAEVVH
OrthoDB	EOG091G0OXR	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0OXR
PRINTS	PR01463	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01463
PRINTS	PR01464	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01464
PROSITE	PS50042	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50042
PROSITE	PS50113	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50113
PSORT	swissprot:KCNH5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNH5_HUMAN
PSORT-B	swissprot:KCNH5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNH5_HUMAN
PSORT2	swissprot:KCNH5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNH5_HUMAN
Pfam	PF00027	http://pfam.xfam.org/family/PF00027
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF13426	http://pfam.xfam.org/family/PF13426
PharmGKB	PA30040	http://www.pharmgkb.org/do/serve?objId=PA30040&objCls=Gene
Phobius	swissprot:KCNH5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNH5_HUMAN
PhylomeDB	Q8NCM2	http://phylomedb.org/?seqid=Q8NCM2
ProteinModelPortal	Q8NCM2	http://www.proteinmodelportal.org/query/uniprot/Q8NCM2
PubMed	11943152	http://www.ncbi.nlm.nih.gov/pubmed/11943152
PubMed	12135768	http://www.ncbi.nlm.nih.gov/pubmed/12135768
PubMed	12508121	http://www.ncbi.nlm.nih.gov/pubmed/12508121
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18655026	http://www.ncbi.nlm.nih.gov/pubmed/18655026
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
RefSeq	NP_647479	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_647479
RefSeq	NP_758963	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_758963
SMART	SM00086	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00086
SMART	SM00100	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00100
SMR	Q8NCM2	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8NCM2
STRING	9606.ENSP00000321427	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000321427&targetmode=cogs
SUPFAM	SSF51206	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51206
SUPFAM	SSF55785	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55785
TIGRFAMs	TIGR00229	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00229
UCSC	uc001xfx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001xfx&org=rat
UniGene	Hs.27043	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.27043
UniProtKB	KCNH5_HUMAN	http://www.uniprot.org/uniprot/KCNH5_HUMAN
UniProtKB-AC	Q8NCM2	http://www.uniprot.org/uniprot/Q8NCM2
charge	swissprot:KCNH5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNH5_HUMAN
eggNOG	ENOG410XPSE	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPSE
eggNOG	KOG0498	http://eggnogapi.embl.de/nog_data/html/tree/KOG0498
epestfind	swissprot:KCNH5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNH5_HUMAN
garnier	swissprot:KCNH5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNH5_HUMAN
helixturnhelix	swissprot:KCNH5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNH5_HUMAN
hmoment	swissprot:KCNH5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNH5_HUMAN
iep	swissprot:KCNH5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNH5_HUMAN
inforesidue	swissprot:KCNH5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNH5_HUMAN
neXtProt	NX_Q8NCM2	http://www.nextprot.org/db/entry/NX_Q8NCM2
octanol	swissprot:KCNH5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNH5_HUMAN
pepcoil	swissprot:KCNH5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNH5_HUMAN
pepdigest	swissprot:KCNH5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNH5_HUMAN
pepinfo	swissprot:KCNH5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNH5_HUMAN
pepnet	swissprot:KCNH5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNH5_HUMAN
pepstats	swissprot:KCNH5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNH5_HUMAN
pepwheel	swissprot:KCNH5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNH5_HUMAN
pepwindow	swissprot:KCNH5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNH5_HUMAN
sigcleave	swissprot:KCNH5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNH5_HUMAN
## Database	ID	URL or Descriptions
# AltName	MOT7_HUMAN	Monocarboxylate transporter 6
# AltName	MOT7_HUMAN	Solute carrier family 16 member 6
# BioGrid	114568	6
# CDD	cd06174	MFS
# DrugBank	DB00119	Pyruvic acid
# Ensembl	ENST00000327268	ENSP00000319991; ENSG00000108932
# Ensembl	ENST00000580666	ENSP00000462985; ENSG00000108932
# ExpressionAtlas	O15403	baseline and differential
# FUNCTION	MOT7_HUMAN	Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). {ECO 0000250}. 
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_function	GO:0008028	monocarboxylic acid transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0015129	lactate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_process	GO:0015718	monocarboxylic acid transport; TAS:ProtInc.
# GO_process	GO:0035879	plasma membrane lactate transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	O15403	HS
# HGNC	HGNC:10927	SLC16A6
# IntAct	O15403	5
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# InterPro	IPR030766	MCT7
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	603880	gene
# Organism	MOT7_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11360:SF20	PTHR11360:SF20
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 17
# RecName	MOT7_HUMAN	Monocarboxylate transporter 7
# RefSeq	NP_001167637	NM_001174166.1
# RefSeq	NP_004685	NM_004694.4
# RefSeq	XP_011523763	XM_011525461.2
# RefSeq	XP_016880780	XM_017025291.1
# RefSeq	XP_016880781	XM_017025292.1
# SEQUENCE CAUTION	Sequence=AAC52014.1; Type=Frameshift; Positions=401, 416; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	MOT7_HUMAN	Cell membrane; Multi-pass membrane protein. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.1.13.15	the major facilitator superfamily (mfs)
# UCSC	uc002jgz	human
# eggNOG	COG0477	LUCA
# eggNOG	KOG2504	Eukaryota
BLAST	swissprot:MOT7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MOT7_HUMAN
BioCyc	ZFISH:ENSG00000108932-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000108932-MONOMER
COXPRESdb	9120	http://coxpresdb.jp/data/gene/9120.shtml
CleanEx	HS_SLC16A6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC16A6
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1042/bj3290321	http://dx.doi.org/10.1042/bj3290321
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00119	http://www.drugbank.ca/drugs/DB00119
EMBL	BC064832	http://www.ebi.ac.uk/ena/data/view/BC064832
EMBL	CH471099	http://www.ebi.ac.uk/ena/data/view/CH471099
EMBL	U79745	http://www.ebi.ac.uk/ena/data/view/U79745
Ensembl	ENST00000327268	http://www.ensembl.org/id/ENST00000327268
Ensembl	ENST00000580666	http://www.ensembl.org/id/ENST00000580666
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0008028	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008028
GO_function	GO:0015129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015129
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_process	GO:0015718	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015718
GO_process	GO:0035879	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035879
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC16A6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC16A6
GeneID	9120	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9120
GeneTree	ENSGT00760000118926	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118926
H-InvDB	HIX0039198	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0039198
HGNC	HGNC:10927	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10927
HOGENOM	HOG000049166	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000049166&db=HOGENOM6
HOVERGEN	HBG006386	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006386&db=HOVERGEN
HPA	HPA054459	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA054459
InParanoid	O15403	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O15403
IntAct	O15403	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O15403*
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
InterPro	IPR030766	http://www.ebi.ac.uk/interpro/entry/IPR030766
Jabion	9120	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9120
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:9120	http://www.genome.jp/dbget-bin/www_bget?hsa:9120
KEGG_Orthology	KO:K08183	http://www.genome.jp/dbget-bin/www_bget?KO:K08183
MIM	603880	http://www.ncbi.nlm.nih.gov/omim/603880
OMA	AFAPAIM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AFAPAIM
OrthoDB	EOG091G04FE	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G04FE
PANTHER	PTHR11360:SF20	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11360:SF20
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:MOT7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MOT7_HUMAN
PSORT-B	swissprot:MOT7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MOT7_HUMAN
PSORT2	swissprot:MOT7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MOT7_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA35818	http://www.pharmgkb.org/do/serve?objId=PA35818&objCls=Gene
Phobius	swissprot:MOT7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MOT7_HUMAN
PhylomeDB	O15403	http://phylomedb.org/?seqid=O15403
ProteinModelPortal	O15403	http://www.proteinmodelportal.org/query/uniprot/O15403
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	9425115	http://www.ncbi.nlm.nih.gov/pubmed/9425115
RefSeq	NP_001167637	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001167637
RefSeq	NP_004685	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004685
RefSeq	XP_011523763	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011523763
RefSeq	XP_016880780	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016880780
RefSeq	XP_016880781	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016880781
STRING	9606.ENSP00000319991	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000319991&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.13.15	http://www.tcdb.org/search/result.php?tc=2.A.1.13.15
UCSC	uc002jgz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002jgz&org=rat
UniGene	Hs.42645	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.42645
UniProtKB	MOT7_HUMAN	http://www.uniprot.org/uniprot/MOT7_HUMAN
UniProtKB-AC	O15403	http://www.uniprot.org/uniprot/O15403
charge	swissprot:MOT7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MOT7_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG2504	http://eggnogapi.embl.de/nog_data/html/tree/KOG2504
epestfind	swissprot:MOT7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MOT7_HUMAN
garnier	swissprot:MOT7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MOT7_HUMAN
helixturnhelix	swissprot:MOT7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MOT7_HUMAN
hmoment	swissprot:MOT7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MOT7_HUMAN
iep	swissprot:MOT7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MOT7_HUMAN
inforesidue	swissprot:MOT7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MOT7_HUMAN
neXtProt	NX_O15403	http://www.nextprot.org/db/entry/NX_O15403
octanol	swissprot:MOT7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MOT7_HUMAN
pepcoil	swissprot:MOT7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MOT7_HUMAN
pepdigest	swissprot:MOT7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MOT7_HUMAN
pepinfo	swissprot:MOT7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MOT7_HUMAN
pepnet	swissprot:MOT7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MOT7_HUMAN
pepstats	swissprot:MOT7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MOT7_HUMAN
pepwheel	swissprot:MOT7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MOT7_HUMAN
pepwindow	swissprot:MOT7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MOT7_HUMAN
sigcleave	swissprot:MOT7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MOT7_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AT12A_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P54707-1; Sequence=Displayed; Name=2; IsoId=P54707-2; Sequence=VSP_034640; Note=No experimental confirmation available.; 
# AltName	AT12A_HUMAN	Non-gastric H(+)/K(+) ATPase subunit alpha
# AltName	AT12A_HUMAN	Proton pump
# BRENDA	3.6.3.10	2681
# BioGrid	106969	57
# CATALYTIC ACTIVITY	AT12A_HUMAN	ATP + H(2)O + H(+)(In) + K(+)(Out) = ADP + phosphate + H(+)(Out) + K(+)(In). 
# CCDS	CCDS31948	-. [P54707-1]
# CCDS	CCDS53858	-. [P54707-2]
# ChiTaRS	ATP12A	human
# Ensembl	ENST00000218548	ENSP00000218548; ENSG00000075673. [P54707-2]
# Ensembl	ENST00000381946	ENSP00000371372; ENSG00000075673. [P54707-1]
# FUNCTION	AT12A_HUMAN	Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues. 
# GO_component	AT12A_HUMAN	GO 0005889 hydrogen potassium-exchanging ATPase complex; TAS ProtInc.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:Ensembl.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IBA:GO_Central.
# GO_function	AT12A_HUMAN	GO 0005391 sodium potassium-exchanging ATPase activity; IBA GO_Central.
# GO_function	AT12A_HUMAN	GO 0008900 hydrogen potassium-exchanging ATPase activity; IBA GO_Central.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0006883	cellular sodium ion homeostasis; IBA:GO_Central.
# GO_process	GO:0006885	regulation of pH; IEA:Ensembl.
# GO_process	GO:0010107	potassium ion import; IBA:GO_Central.
# GO_process	GO:0015991	ATP hydrolysis coupled proton transport; IBA:GO_Central.
# GO_process	GO:0030007	cellular potassium ion homeostasis; IBA:GO_Central.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0036376	sodium ion export from cell; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.1110.10	-; 2.
# Gene3D	2.70.150.10	-; 2.
# Gene3D	3.40.1110.10	-; 1.
# Genevisible	P54707	HS
# HGNC	HGNC:13816	ATP12A
# IntAct	P54707	4
# InterPro	IPR001757	P_typ_ATPase
# InterPro	IPR004014	ATPase_P-typ_cation-transptr_N
# InterPro	IPR005775	P-type_ATPase_IIC
# InterPro	IPR006068	ATPase_P-typ_cation-transptr_C
# InterPro	IPR008250	ATPase_P-typ_transduc_dom_A
# InterPro	IPR018303	ATPase_P-typ_P_site
# InterPro	IPR023214	HAD-like_dom
# InterPro	IPR023298	ATPase_P-typ_TM_dom
# InterPro	IPR023299	ATPase_P-typ_cyto_domN
# InterPro	IPR030318	Atp12a
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# MIM	182360	gene
# Organism	AT12A_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR24093:SF282	PTHR24093:SF282; 2
# PIR	A26641	A26641
# PIR	D27795	D27795
# PIR	E27397	E27397
# PIR	I38401	I38401
# PIR	S13028	S13028
# PIR	S31504	S31504
# PROSITE	PS00154	ATPASE_E1_E2
# Pfam	PF00122	E1-E2_ATPase
# Pfam	PF00689	Cation_ATPase_C
# Pfam	PF00690	Cation_ATPase_N
# Proteomes	UP000005640	Chromosome 13
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	AT12A_HUMAN	Potassium-transporting ATPase alpha chain 2
# RefSeq	NP_001172014	NM_001185085.1. [P54707-2]
# RefSeq	NP_001667	NM_001676.5. [P54707-1]
# SIMILARITY	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. {ECO	0000305}.
# SMART	SM00831	Cation_ATPase_N
# SUBCELLULAR LOCATION	AT12A_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Composed of two subunits	 alpha (catalytic) and beta. 
# SUPFAM	SSF56784	SSF56784
# SUPFAM	SSF81660	SSF81660
# TCDB	3.A.3.1.13	the p-type atpase (p-atpase) superfamily
# TIGRFAMs	TIGR01106	ATPase-IIC_X-K
# TIGRFAMs	TIGR01494	ATPase_P-type; 2
# TISSUE SPECIFICITY	AT12A_HUMAN	Found in skin and kidney. Detected in prostate basal cells (at protein level). Expression is increased in benign prostate hyperplasia and tumor tissues (at protein level). {ECO 0000269|PubMed 22179016, ECO 0000269|PubMed 9872395}. 
# UCSC	uc001upp	human. [P54707-1]
# eggNOG	COG0474	LUCA
# eggNOG	KOG0203	Eukaryota
BLAST	swissprot:AT12A_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AT12A_HUMAN
BioCyc	ZFISH:HS01186-MONOMER	http://biocyc.org/getid?id=ZFISH:HS01186-MONOMER
COXPRESdb	479	http://coxpresdb.jp/data/gene/479.shtml
CleanEx	HS_ATP12A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP12A
DOI	10.1006/geno.1996.0125	http://dx.doi.org/10.1006/geno.1996.0125
DOI	10.1016/0014-5793(87)80677-4	http://dx.doi.org/10.1016/0014-5793(87)80677-4
DOI	10.1016/0014-5793(91)80091-G	http://dx.doi.org/10.1016/0014-5793(91)80091-G
DOI	10.1016/0014-5793(94)00655-5	http://dx.doi.org/10.1016/0014-5793(94)00655-5
DOI	10.1016/S0014-5793(98)01483-5	http://dx.doi.org/10.1016/S0014-5793(98)01483-5
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature02379	http://dx.doi.org/10.1038/nature02379
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.84.12.4039	http://dx.doi.org/10.1073/pnas.84.12.4039
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1159/000335860	http://dx.doi.org/10.1159/000335860
EC_number	EC:3.6.3.10	http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.10
EMBL	AK292968	http://www.ebi.ac.uk/ena/data/view/AK292968
EMBL	AL157364	http://www.ebi.ac.uk/ena/data/view/AL157364
EMBL	BC031609	http://www.ebi.ac.uk/ena/data/view/BC031609
EMBL	CH471075	http://www.ebi.ac.uk/ena/data/view/CH471075
EMBL	CH471075	http://www.ebi.ac.uk/ena/data/view/CH471075
EMBL	L42558	http://www.ebi.ac.uk/ena/data/view/L42558
EMBL	L42559	http://www.ebi.ac.uk/ena/data/view/L42559
EMBL	L42560	http://www.ebi.ac.uk/ena/data/view/L42560
EMBL	L42561	http://www.ebi.ac.uk/ena/data/view/L42561
EMBL	L42562	http://www.ebi.ac.uk/ena/data/view/L42562
EMBL	L42563	http://www.ebi.ac.uk/ena/data/view/L42563
EMBL	L42565	http://www.ebi.ac.uk/ena/data/view/L42565
EMBL	L42566	http://www.ebi.ac.uk/ena/data/view/L42566
EMBL	L42567	http://www.ebi.ac.uk/ena/data/view/L42567
EMBL	L42568	http://www.ebi.ac.uk/ena/data/view/L42568
EMBL	L42569	http://www.ebi.ac.uk/ena/data/view/L42569
EMBL	M16797	http://www.ebi.ac.uk/ena/data/view/M16797
EMBL	M27574	http://www.ebi.ac.uk/ena/data/view/M27574
EMBL	U02076	http://www.ebi.ac.uk/ena/data/view/U02076
EMBL	X69823	http://www.ebi.ac.uk/ena/data/view/X69823
EMBL	X69824	http://www.ebi.ac.uk/ena/data/view/X69824
ENZYME	3.6.3.10	http://enzyme.expasy.org/EC/3.6.3.10
Ensembl	ENST00000218548	http://www.ensembl.org/id/ENST00000218548
Ensembl	ENST00000381946	http://www.ensembl.org/id/ENST00000381946
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005889	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005889
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0005391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005391
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0008900	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008900
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006883	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006883
GO_process	GO:0006885	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006885
GO_process	GO:0010107	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010107
GO_process	GO:0015991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015991
GO_process	GO:0030007	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030007
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0036376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036376
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.1110.10	http://www.cathdb.info/version/latest/superfamily/1.20.1110.10
Gene3D	2.70.150.10	http://www.cathdb.info/version/latest/superfamily/2.70.150.10
Gene3D	3.40.1110.10	http://www.cathdb.info/version/latest/superfamily/3.40.1110.10
GeneCards	ATP12A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP12A
GeneID	479	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=479
GeneTree	ENSGT00850000132256	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00850000132256
HGNC	HGNC:13816	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13816
HOGENOM	HOG000265622	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265622&db=HOGENOM6
HOVERGEN	HBG004298	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004298&db=HOVERGEN
HPA	HPA039526	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA039526
InParanoid	P54707	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P54707
IntAct	P54707	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P54707*
IntEnz	3.6.3.10	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.10
InterPro	IPR001757	http://www.ebi.ac.uk/interpro/entry/IPR001757
InterPro	IPR004014	http://www.ebi.ac.uk/interpro/entry/IPR004014
InterPro	IPR005775	http://www.ebi.ac.uk/interpro/entry/IPR005775
InterPro	IPR006068	http://www.ebi.ac.uk/interpro/entry/IPR006068
InterPro	IPR008250	http://www.ebi.ac.uk/interpro/entry/IPR008250
InterPro	IPR018303	http://www.ebi.ac.uk/interpro/entry/IPR018303
InterPro	IPR023214	http://www.ebi.ac.uk/interpro/entry/IPR023214
InterPro	IPR023298	http://www.ebi.ac.uk/interpro/entry/IPR023298
InterPro	IPR023299	http://www.ebi.ac.uk/interpro/entry/IPR023299
InterPro	IPR030318	http://www.ebi.ac.uk/interpro/entry/IPR030318
Jabion	479	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=479
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:479	http://www.genome.jp/dbget-bin/www_bget?hsa:479
KEGG_Orthology	KO:K01544	http://www.genome.jp/dbget-bin/www_bget?KO:K01544
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
MIM	182360	http://www.ncbi.nlm.nih.gov/omim/182360
MINT	MINT-4656898	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4656898
OMA	NQVFDQS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NQVFDQS
OrthoDB	EOG091G01BB	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01BB
PANTHER	PTHR24093:SF282	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24093:SF282
PROSITE	PS00154	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00154
PSORT	swissprot:AT12A_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AT12A_HUMAN
PSORT-B	swissprot:AT12A_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AT12A_HUMAN
PSORT2	swissprot:AT12A_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AT12A_HUMAN
Pfam	PF00122	http://pfam.xfam.org/family/PF00122
Pfam	PF00689	http://pfam.xfam.org/family/PF00689
Pfam	PF00690	http://pfam.xfam.org/family/PF00690
PharmGKB	PA25104	http://www.pharmgkb.org/do/serve?objId=PA25104&objCls=Gene
Phobius	swissprot:AT12A_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AT12A_HUMAN
PhylomeDB	P54707	http://phylomedb.org/?seqid=P54707
ProteinModelPortal	P54707	http://www.proteinmodelportal.org/query/uniprot/P54707
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15057823	http://www.ncbi.nlm.nih.gov/pubmed/15057823
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	1847115	http://www.ncbi.nlm.nih.gov/pubmed/1847115
PubMed	22179016	http://www.ncbi.nlm.nih.gov/pubmed/22179016
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	3035563	http://www.ncbi.nlm.nih.gov/pubmed/3035563
PubMed	3036582	http://www.ncbi.nlm.nih.gov/pubmed/3036582
PubMed	8045293	http://www.ncbi.nlm.nih.gov/pubmed/8045293
PubMed	8838794	http://www.ncbi.nlm.nih.gov/pubmed/8838794
PubMed	9872395	http://www.ncbi.nlm.nih.gov/pubmed/9872395
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_001172014	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001172014
RefSeq	NP_001667	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001667
SMART	SM00831	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00831
SMR	P54707	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P54707
STRING	9606.ENSP00000218548	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000218548&targetmode=cogs
SUPFAM	SSF56784	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784
SUPFAM	SSF81660	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81660
TCDB	3.A.3.1.13	http://www.tcdb.org/search/result.php?tc=3.A.3.1.13
TIGRFAMs	TIGR01106	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01106
TIGRFAMs	TIGR01494	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01494
UCSC	uc001upp	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001upp&org=rat
UniGene	Hs.147111	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.147111
UniProtKB	AT12A_HUMAN	http://www.uniprot.org/uniprot/AT12A_HUMAN
UniProtKB-AC	P54707	http://www.uniprot.org/uniprot/P54707
charge	swissprot:AT12A_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AT12A_HUMAN
eggNOG	COG0474	http://eggnogapi.embl.de/nog_data/html/tree/COG0474
eggNOG	KOG0203	http://eggnogapi.embl.de/nog_data/html/tree/KOG0203
epestfind	swissprot:AT12A_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AT12A_HUMAN
garnier	swissprot:AT12A_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AT12A_HUMAN
helixturnhelix	swissprot:AT12A_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AT12A_HUMAN
hmoment	swissprot:AT12A_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AT12A_HUMAN
iep	swissprot:AT12A_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AT12A_HUMAN
inforesidue	swissprot:AT12A_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AT12A_HUMAN
neXtProt	NX_P54707	http://www.nextprot.org/db/entry/NX_P54707
octanol	swissprot:AT12A_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AT12A_HUMAN
pepcoil	swissprot:AT12A_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AT12A_HUMAN
pepdigest	swissprot:AT12A_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AT12A_HUMAN
pepinfo	swissprot:AT12A_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AT12A_HUMAN
pepnet	swissprot:AT12A_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AT12A_HUMAN
pepstats	swissprot:AT12A_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AT12A_HUMAN
pepwheel	swissprot:AT12A_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AT12A_HUMAN
pepwindow	swissprot:AT12A_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AT12A_HUMAN
sigcleave	swissprot:AT12A_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AT12A_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNN2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H2S1-1; Sequence=Displayed; Name=2; IsoId=Q9H2S1-2; Sequence=VSP_044584; 
# AltName	KCNN2_HUMAN	KCa2.2
# BioGrid	109982	5
# CCDS	CCDS4114	-. [Q9H2S1-1]
# CCDS	CCDS43352	-. [Q9H2S1-2]
# ChiTaRS	KCNN2	human
# DrugBank	DB00721	Procaine
# DrugBank	DB01110	Miconazole
# Ensembl	ENST00000264773	ENSP00000264773; ENSG00000080709. [Q9H2S1-1]
# Ensembl	ENST00000503706	ENSP00000421439; ENSG00000080709. [Q9H2S1-2]
# Ensembl	ENST00000512097	ENSP00000427120; ENSG00000080709. [Q9H2S1-1]
# Ensembl	ENST00000610748	ENSP00000483124; ENSG00000080709. [Q9H2S1-2]
# ExpressionAtlas	Q9H2S1	baseline and differential
# FUNCTION	KCNN2_HUMAN	Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. 
# GO_component	GO:0005790	smooth endoplasmic reticulum; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0009986	cell surface; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0030018	Z disc; IEA:Ensembl.
# GO_component	GO:0030315	T-tubule; IEA:Ensembl.
# GO_component	GO:0043025	neuronal cell body; IBA:GO_Central.
# GO_component	GO:0043197	dendritic spine; IBA:GO_Central.
# GO_function	GO:0005516	calmodulin binding; IBA:GO_Central.
# GO_function	GO:0015269	calcium-activated potassium channel activity; IDA:BHF-UCL.
# GO_function	GO:0016286	small conductance calcium-activated potassium channel activity; IMP:UniProtKB.
# GO_function	GO:0019904	protein domain specific binding; IPI:UniProtKB.
# GO_function	GO:0042803	protein homodimerization activity; IPI:BHF-UCL.
# GO_function	GO:0051393	alpha-actinin binding; IPI:BHF-UCL.
# GO_process	GO:0006813	potassium ion transport; NAS:UniProtKB.
# GO_process	GO:0071805	potassium ion transmembrane transport; IDA:BHF-UCL.
# GO_process	GO:1901379	regulation of potassium ion transmembrane transport; IDA:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008092	cytoskeletal protein binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9H2S1	HS
# HGNC	HGNC:6291	KCNN2
# IntAct	Q9H2S1	2
# InterPro	IPR004178	CaM-bd_dom
# InterPro	IPR013099	K_chnl_dom
# InterPro	IPR015449	K_chnl_Ca-activ_SK
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04726	Serotonergic synapse
# KEGG_Pathway	ko04976	Bile secretion
# MIM	605879	gene
# Organism	KCNN2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10153	PTHR10153
# PRINTS	PR01451	SKCHANNEL
# Pfam	PF02888	CaMBD
# Pfam	PF03530	SK_channel
# Pfam	PF07885	Ion_trans_2
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-1296052	Ca2+ activated K+ channels
# RecName	KCNN2_HUMAN	Small conductance calcium-activated potassium channel protein 2
# RefSeq	NP_001265133	NM_001278204.1. [Q9H2S1-2]
# RefSeq	NP_067627	NM_021614.3. [Q9H2S1-1]
# RefSeq	NP_740721	NM_170775.2. [Q9H2S1-2]
# SIMILARITY	Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily. {ECO	0000305}.
# SMART	SM01053	CaMBD
# SUBCELLULAR LOCATION	KCNN2_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity). {ECO	0000250}. 
# SUPFAM	SSF81327	SSF81327
# TCDB	1.A.1.16	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	Expressed in atrial myocytes (at protein level). Widely expressed. {ECO:0000269|PubMed	13679367}. 
# UCSC	uc003kqo	human. [Q9H2S1-1]
# eggNOG	ENOG410XT9D	LUCA
# eggNOG	KOG3684	Eukaryota
BLAST	swissprot:KCNN2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNN2_HUMAN
BioCyc	ZFISH:ENSG00000080709-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000080709-MONOMER
COXPRESdb	3781	http://coxpresdb.jp/data/gene/3781.shtml
CleanEx	HS_KCNN2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNN2
DIP	DIP-48997N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48997N
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M001562200	http://dx.doi.org/10.1074/jbc.M001562200
DOI	10.1074/jbc.M307508200	http://dx.doi.org/10.1074/jbc.M307508200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00721	http://www.drugbank.ca/drugs/DB00721
DrugBank	DB01110	http://www.drugbank.ca/drugs/DB01110
EMBL	AC025761	http://www.ebi.ac.uk/ena/data/view/AC025761
EMBL	AC109482	http://www.ebi.ac.uk/ena/data/view/AC109482
EMBL	AF239613	http://www.ebi.ac.uk/ena/data/view/AF239613
EMBL	AF397175	http://www.ebi.ac.uk/ena/data/view/AF397175
EMBL	AK289948	http://www.ebi.ac.uk/ena/data/view/AK289948
EMBL	AY258141	http://www.ebi.ac.uk/ena/data/view/AY258141
EMBL	BC015371	http://www.ebi.ac.uk/ena/data/view/BC015371
EMBL	BC117454	http://www.ebi.ac.uk/ena/data/view/BC117454
EMBL	BC117456	http://www.ebi.ac.uk/ena/data/view/BC117456
EMBL	CH471086	http://www.ebi.ac.uk/ena/data/view/CH471086
EMBL	CH471086	http://www.ebi.ac.uk/ena/data/view/CH471086
Ensembl	ENST00000264773	http://www.ensembl.org/id/ENST00000264773
Ensembl	ENST00000503706	http://www.ensembl.org/id/ENST00000503706
Ensembl	ENST00000512097	http://www.ensembl.org/id/ENST00000512097
Ensembl	ENST00000610748	http://www.ensembl.org/id/ENST00000610748
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005790
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030018	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030018
GO_component	GO:0030315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030315
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0043197	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043197
GO_function	GO:0005516	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005516
GO_function	GO:0015269	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015269
GO_function	GO:0016286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016286
GO_function	GO:0019904	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019904
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_function	GO:0051393	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051393
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GO_process	GO:1901379	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901379
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	KCNN2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNN2
GeneID	3781	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3781
GeneTree	ENSGT00500000044784	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00500000044784
HGNC	HGNC:6291	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6291
HOGENOM	HOG000124679	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124679&db=HOGENOM6
HOVERGEN	HBG052241	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052241&db=HOVERGEN
HPA	HPA038221	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA038221
InParanoid	Q9H2S1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9H2S1
IntAct	Q9H2S1	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9H2S1*
InterPro	IPR004178	http://www.ebi.ac.uk/interpro/entry/IPR004178
InterPro	IPR013099	http://www.ebi.ac.uk/interpro/entry/IPR013099
InterPro	IPR015449	http://www.ebi.ac.uk/interpro/entry/IPR015449
Jabion	3781	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3781
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3781	http://www.genome.jp/dbget-bin/www_bget?hsa:3781
KEGG_Orthology	KO:K04943	http://www.genome.jp/dbget-bin/www_bget?KO:K04943
KEGG_Pathway	ko04726	http://www.genome.jp/kegg-bin/show_pathway?ko04726
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
MIM	605879	http://www.ncbi.nlm.nih.gov/omim/605879
OMA	MESYDKH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MESYDKH
OrthoDB	EOG091G03YH	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G03YH
PANTHER	PTHR10153	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10153
PRINTS	PR01451	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01451
PSORT	swissprot:KCNN2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNN2_HUMAN
PSORT-B	swissprot:KCNN2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNN2_HUMAN
PSORT2	swissprot:KCNN2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNN2_HUMAN
Pfam	PF02888	http://pfam.xfam.org/family/PF02888
Pfam	PF03530	http://pfam.xfam.org/family/PF03530
Pfam	PF07885	http://pfam.xfam.org/family/PF07885
PharmGKB	PA30071	http://www.pharmgkb.org/do/serve?objId=PA30071&objCls=Gene
Phobius	swissprot:KCNN2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNN2_HUMAN
PhylomeDB	Q9H2S1	http://phylomedb.org/?seqid=Q9H2S1
ProteinModelPortal	Q9H2S1	http://www.proteinmodelportal.org/query/uniprot/Q9H2S1
PubMed	10991935	http://www.ncbi.nlm.nih.gov/pubmed/10991935
PubMed	13679367	http://www.ncbi.nlm.nih.gov/pubmed/13679367
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-1296052	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296052
RefSeq	NP_001265133	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001265133
RefSeq	NP_067627	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_067627
RefSeq	NP_740721	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_740721
SMART	SM01053	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01053
SMR	Q9H2S1	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9H2S1
STRING	9606.ENSP00000264773	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000264773&targetmode=cogs
SUPFAM	SSF81327	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81327
TCDB	1.A.1.16	http://www.tcdb.org/search/result.php?tc=1.A.1.16
UCSC	uc003kqo	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003kqo&org=rat
UniGene	Hs.582520	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.582520
UniGene	Hs.98280	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.98280
UniProtKB	KCNN2_HUMAN	http://www.uniprot.org/uniprot/KCNN2_HUMAN
UniProtKB-AC	Q9H2S1	http://www.uniprot.org/uniprot/Q9H2S1
charge	swissprot:KCNN2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNN2_HUMAN
eggNOG	ENOG410XT9D	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XT9D
eggNOG	KOG3684	http://eggnogapi.embl.de/nog_data/html/tree/KOG3684
epestfind	swissprot:KCNN2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNN2_HUMAN
garnier	swissprot:KCNN2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNN2_HUMAN
helixturnhelix	swissprot:KCNN2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNN2_HUMAN
hmoment	swissprot:KCNN2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNN2_HUMAN
iep	swissprot:KCNN2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNN2_HUMAN
inforesidue	swissprot:KCNN2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNN2_HUMAN
neXtProt	NX_Q9H2S1	http://www.nextprot.org/db/entry/NX_Q9H2S1
octanol	swissprot:KCNN2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNN2_HUMAN
pepcoil	swissprot:KCNN2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNN2_HUMAN
pepdigest	swissprot:KCNN2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNN2_HUMAN
pepinfo	swissprot:KCNN2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNN2_HUMAN
pepnet	swissprot:KCNN2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNN2_HUMAN
pepstats	swissprot:KCNN2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNN2_HUMAN
pepwheel	swissprot:KCNN2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNN2_HUMAN
pepwindow	swissprot:KCNN2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNN2_HUMAN
sigcleave	swissprot:KCNN2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNN2_HUMAN
## Database	ID	URL or Descriptions
# AltName	COX7R_HUMAN	COX7a-related protein
# AltName	COX7R_HUMAN	Cytochrome c oxidase subunit VIIa-related protein
# AltName	COX7R_HUMAN	EB1
# BioGrid	114608	14
# CDD	cd00928	Cyt_c_Oxidase_VIIa
# Ensembl	ENST00000234301	ENSP00000234301; ENSG00000115944
# Ensembl	ENST00000378669	ENSP00000367938; ENSG00000115944
# ExpressionAtlas	O14548	baseline and differential
# FUNCTION	COX7R_HUMAN	Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitochondrial respiratory supercomplex (By similarity). {ECO 0000250|UniProtKB Q61387}. 
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0005746	mitochondrial respiratory chain; IEA:InterPro.
# GO_function	GO:0004129	cytochrome-c oxidase activity; TAS:ProtInc.
# GO_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# Gene3D	4.10.91.10	-; 1.
# Genevisible	O14548	HS
# HGNC	HGNC:2289	COX7A2L
# INDUCTION	COX7R_HUMAN	By estrogen. 
# IntAct	O14548	4
# InterPro	IPR003177	Cyt_c_oxidase_su7a
# InterPro	IPR017267	Cyt_c_oxidase_su7a-rel_mt
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	605771	gene
# Organism	COX7R_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10510	PTHR10510
# PANTHER	PTHR10510:SF2	PTHR10510:SF2
# PIRSF	PIRSF037710	COX7A-rel_mt
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-5628897	TP53 Regulates Metabolic Genes
# Reactome	R-HSA-611105	Respiratory electron transport
# RecName	COX7R_HUMAN	Cytochrome c oxidase subunit 7A-related protein, mitochondrial
# RefSeq	NP_001305965	NM_001319036.1
# RefSeq	NP_001305969	NM_001319040.1
# RefSeq	NP_004709	NM_004718.3
# SIMILARITY	Belongs to the cytochrome c oxidase VIIa family. {ECO	0000305}.
# SUBCELLULAR LOCATION	COX7R_HUMAN	Mitochondrion inner membrane {ECO 0000250}. 
# SUBUNIT	Interacts with the mitochondrial respiratory supercomplex. {ECO:0000250|UniProtKB	Q61387}. 
# SUPFAM	SSF81419	SSF81419
# eggNOG	ENOG410IYMH	Eukaryota
# eggNOG	ENOG41120Z9	LUCA
BLAST	swissprot:COX7R_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:COX7R_HUMAN
BioCyc	ZFISH:HS03956-MONOMER	http://biocyc.org/getid?id=ZFISH:HS03956-MONOMER
COXPRESdb	9167	http://coxpresdb.jp/data/gene/9167.shtml
CleanEx	HS_COX7A2L	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_COX7A2L
DOI	10.1086/318197	http://dx.doi.org/10.1086/318197
DOI	10.1093/oxfordjournals.molbev.a026144	http://dx.doi.org/10.1093/oxfordjournals.molbev.a026144
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1128/MCB.18.1.442	http://dx.doi.org/10.1128/MCB.18.1.442
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AB007618	http://www.ebi.ac.uk/ena/data/view/AB007618
EMBL	AF127788	http://www.ebi.ac.uk/ena/data/view/AF127788
EMBL	AY007643	http://www.ebi.ac.uk/ena/data/view/AY007643
EMBL	BC005251	http://www.ebi.ac.uk/ena/data/view/BC005251
EMBL	BC007095	http://www.ebi.ac.uk/ena/data/view/BC007095
EMBL	BT007371	http://www.ebi.ac.uk/ena/data/view/BT007371
Ensembl	ENST00000234301	http://www.ensembl.org/id/ENST00000234301
Ensembl	ENST00000378669	http://www.ensembl.org/id/ENST00000378669
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005746	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005746
GO_function	GO:0004129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004129
GO_process	GO:0006123	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006123
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
Gene3D	4.10.91.10	http://www.cathdb.info/version/latest/superfamily/4.10.91.10
GeneCards	COX7A2L	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=COX7A2L
GeneID	9167	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9167
GeneTree	ENSGT00400000022054	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00400000022054
HGNC	HGNC:2289	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2289
HOGENOM	HOG000264231	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264231&db=HOGENOM6
HOVERGEN	HBG051095	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051095&db=HOVERGEN
HPA	CAB073545	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB073545
HPA	HPA059124	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA059124
InParanoid	O14548	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O14548
IntAct	O14548	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O14548*
InterPro	IPR003177	http://www.ebi.ac.uk/interpro/entry/IPR003177
InterPro	IPR017267	http://www.ebi.ac.uk/interpro/entry/IPR017267
Jabion	9167	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9167
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Gene	hsa:9167	http://www.genome.jp/dbget-bin/www_bget?hsa:9167
KEGG_Orthology	KO:K02270	http://www.genome.jp/dbget-bin/www_bget?KO:K02270
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	605771	http://www.ncbi.nlm.nih.gov/omim/605771
MINT	MINT-1484437	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1484437
OMA	YFAAQPN	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YFAAQPN
OrthoDB	EOG091G12UD	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G12UD
PANTHER	PTHR10510	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10510
PANTHER	PTHR10510:SF2	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10510:SF2
PSORT	swissprot:COX7R_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:COX7R_HUMAN
PSORT-B	swissprot:COX7R_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:COX7R_HUMAN
PSORT2	swissprot:COX7R_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:COX7R_HUMAN
PharmGKB	PA26807	http://www.pharmgkb.org/do/serve?objId=PA26807&objCls=Gene
Phobius	swissprot:COX7R_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:COX7R_HUMAN
PhylomeDB	O14548	http://phylomedb.org/?seqid=O14548
ProteinModelPortal	O14548	http://www.proteinmodelportal.org/query/uniprot/O14548
PubMed	10335655	http://www.ncbi.nlm.nih.gov/pubmed/10335655
PubMed	11156535	http://www.ncbi.nlm.nih.gov/pubmed/11156535
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	9418891	http://www.ncbi.nlm.nih.gov/pubmed/9418891
Reactome	R-HSA-5628897	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5628897
Reactome	R-HSA-611105	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-611105
RefSeq	NP_001305965	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001305965
RefSeq	NP_001305969	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001305969
RefSeq	NP_004709	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004709
SMR	O14548	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O14548
STRING	9606.ENSP00000234301	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000234301&targetmode=cogs
SUPFAM	SSF81419	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81419
UniGene	Hs.339639	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.339639
UniGene	Hs.744101	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.744101
UniProtKB	COX7R_HUMAN	http://www.uniprot.org/uniprot/COX7R_HUMAN
UniProtKB-AC	O14548	http://www.uniprot.org/uniprot/O14548
charge	swissprot:COX7R_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:COX7R_HUMAN
eggNOG	ENOG410IYMH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IYMH
eggNOG	ENOG41120Z9	http://eggnogapi.embl.de/nog_data/html/tree/ENOG41120Z9
epestfind	swissprot:COX7R_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:COX7R_HUMAN
garnier	swissprot:COX7R_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:COX7R_HUMAN
helixturnhelix	swissprot:COX7R_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:COX7R_HUMAN
hmoment	swissprot:COX7R_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:COX7R_HUMAN
iep	swissprot:COX7R_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:COX7R_HUMAN
inforesidue	swissprot:COX7R_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:COX7R_HUMAN
neXtProt	NX_O14548	http://www.nextprot.org/db/entry/NX_O14548
octanol	swissprot:COX7R_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:COX7R_HUMAN
pepcoil	swissprot:COX7R_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:COX7R_HUMAN
pepdigest	swissprot:COX7R_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:COX7R_HUMAN
pepinfo	swissprot:COX7R_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:COX7R_HUMAN
pepnet	swissprot:COX7R_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:COX7R_HUMAN
pepstats	swissprot:COX7R_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:COX7R_HUMAN
pepwheel	swissprot:COX7R_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:COX7R_HUMAN
pepwindow	swissprot:COX7R_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:COX7R_HUMAN
sigcleave	swissprot:COX7R_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:COX7R_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	FXYD5_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96DB9-1; Sequence=Displayed; Name=2; IsoId=Q96DB9-2; Sequence=VSP_001584; 
# AltName	FXYD5_HUMAN	Dysadherin
# CCDS	CCDS12447	-. [Q96DB9-1]
# ChiTaRS	FXYD5	human
# Ensembl	ENST00000342879	ENSP00000344254; ENSG00000089327. [Q96DB9-1]
# Ensembl	ENST00000392217	ENSP00000376051; ENSG00000089327. [Q96DB9-2]
# Ensembl	ENST00000392219	ENSP00000376053; ENSG00000089327. [Q96DB9-1]
# Ensembl	ENST00000423817	ENSP00000393848; ENSG00000089327. [Q96DB9-1]
# Ensembl	ENST00000541435	ENSP00000443390; ENSG00000089327. [Q96DB9-1]
# Ensembl	ENST00000590686	ENSP00000465667; ENSG00000089327. [Q96DB9-1]
# ExpressionAtlas	Q96DB9	baseline and differential
# FUNCTION	FXYD5_HUMAN	Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis. {ECO 0000269|PubMed 11756660}. 
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IDA:UniProtKB.
# GO_function	GO:0003779	actin binding; IDA:UniProtKB.
# GO_function	GO:0005216	ion channel activity; IEA:InterPro.
# GO_function	GO:0017080	sodium channel regulator activity; IBA:GO_Central.
# GO_function	GO:0045296	cadherin binding; IDA:UniProtKB.
# GO_process	GO:0030033	microvillus assembly; NAS:UniProtKB.
# GO_process	GO:0046588	negative regulation of calcium-dependent cell-cell adhesion; NAS:UniProtKB.
# GO_process	GO:2000649	regulation of sodium ion transmembrane transporter activity; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008092	cytoskeletal protein binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0022607	cellular component assembly
# Genevisible	Q96DB9	HS
# HGNC	HGNC:4029	FXYD5
# InterPro	IPR000272	Ion-transport_regulator_FXYD
# KEGG_Brite	ko02000	Transporters
# MIM	606669	gene
# Organism	FXYD5_HUMAN	Homo sapiens (Human)
# PROSITE	PS01310	FXYD
# PTM	FXYD5_HUMAN	Glycosylated. {ECO 0000269|PubMed 11756660}. 
# Pfam	PF02038	ATP1G1_PLM_MAT8
# ProDom	PD005989	PD005989
# Proteomes	UP000005640	Chromosome 19
# RecName	FXYD5_HUMAN	FXYD domain-containing ion transport regulator 5
# RefSeq	NP_001158077	NM_001164605.1. [Q96DB9-1]
# RefSeq	NP_001307842	NM_001320913.1
# RefSeq	NP_054883	NM_014164.5. [Q96DB9-1]
# RefSeq	NP_659003	NM_144779.2. [Q96DB9-1]
# SIMILARITY	Belongs to the FXYD family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	FXYD5_HUMAN	Membrane {ECO 0000305}; Single-pass type I membrane protein {ECO 0000305}. 
# TCDB	1.A.27.3	the phospholemman (plm) family
# UCSC	uc002nyg	human. [Q96DB9-1]
# WEB RESOURCE	FXYD5_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/FXYD5ID40652ch19q13.html";
# eggNOG	ENOG410JCU8	Eukaryota
# eggNOG	ENOG4111E7R	LUCA
BLAST	swissprot:FXYD5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:FXYD5_HUMAN
BioCyc	ZFISH:ENSG00000089327-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000089327-MONOMER
COXPRESdb	53827	http://coxpresdb.jp/data/gene/53827.shtml
CleanEx	HS_FXYD5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_FXYD5
DOI	10.1016/S0167-4781(00)00251-7	http://dx.doi.org/10.1016/S0167-4781(00)00251-7
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DOI	10.1073/pnas.012425299	http://dx.doi.org/10.1073/pnas.012425299
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.140200	http://dx.doi.org/10.1101/gr.140200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB072911	http://www.ebi.ac.uk/ena/data/view/AB072911
EMBL	AC002390	http://www.ebi.ac.uk/ena/data/view/AC002390
EMBL	AC020907	http://www.ebi.ac.uk/ena/data/view/AC020907
EMBL	AF161462	http://www.ebi.ac.uk/ena/data/view/AF161462
EMBL	AF177940	http://www.ebi.ac.uk/ena/data/view/AF177940
EMBL	AY358991	http://www.ebi.ac.uk/ena/data/view/AY358991
EMBL	BC009642	http://www.ebi.ac.uk/ena/data/view/BC009642
EMBL	BT007343	http://www.ebi.ac.uk/ena/data/view/BT007343
Ensembl	ENST00000342879	http://www.ensembl.org/id/ENST00000342879
Ensembl	ENST00000392217	http://www.ensembl.org/id/ENST00000392217
Ensembl	ENST00000392219	http://www.ensembl.org/id/ENST00000392219
Ensembl	ENST00000423817	http://www.ensembl.org/id/ENST00000423817
Ensembl	ENST00000541435	http://www.ensembl.org/id/ENST00000541435
Ensembl	ENST00000590686	http://www.ensembl.org/id/ENST00000590686
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0003779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003779
GO_function	GO:0005216	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005216
GO_function	GO:0017080	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017080
GO_function	GO:0045296	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045296
GO_process	GO:0030033	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030033
GO_process	GO:0046588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046588
GO_process	GO:2000649	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000649
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0022607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607
GeneCards	FXYD5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=FXYD5
GeneID	53827	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=53827
GeneTree	ENSGT00410000026316	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00410000026316
H-InvDB	HIX0015022	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0015022
HGNC	HGNC:4029	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4029
HOGENOM	HOG000081775	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000081775&db=HOGENOM6
HOVERGEN	HBG051678	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051678&db=HOVERGEN
HPA	HPA010817	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA010817
InParanoid	Q96DB9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96DB9
InterPro	IPR000272	http://www.ebi.ac.uk/interpro/entry/IPR000272
Jabion	53827	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=53827
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:53827	http://www.genome.jp/dbget-bin/www_bget?hsa:53827
KEGG_Orthology	KO:K13362	http://www.genome.jp/dbget-bin/www_bget?KO:K13362
MIM	606669	http://www.ncbi.nlm.nih.gov/omim/606669
PROSITE	PS01310	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01310
PSORT	swissprot:FXYD5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:FXYD5_HUMAN
PSORT-B	swissprot:FXYD5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:FXYD5_HUMAN
PSORT2	swissprot:FXYD5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:FXYD5_HUMAN
Pfam	PF02038	http://pfam.xfam.org/family/PF02038
PharmGKB	PA28445	http://www.pharmgkb.org/do/serve?objId=PA28445&objCls=Gene
Phobius	swissprot:FXYD5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:FXYD5_HUMAN
PhylomeDB	Q96DB9	http://phylomedb.org/?seqid=Q96DB9
ProteinModelPortal	Q96DB9	http://www.proteinmodelportal.org/query/uniprot/Q96DB9
PubMed	11042152	http://www.ncbi.nlm.nih.gov/pubmed/11042152
PubMed	11342114	http://www.ncbi.nlm.nih.gov/pubmed/11342114
PubMed	11756660	http://www.ncbi.nlm.nih.gov/pubmed/11756660
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
RefSeq	NP_001158077	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001158077
RefSeq	NP_001307842	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001307842
RefSeq	NP_054883	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_054883
RefSeq	NP_659003	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_659003
SMR	Q96DB9	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q96DB9
STRING	9606.ENSP00000344254	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000344254&targetmode=cogs
TCDB	1.A.27.3	http://www.tcdb.org/search/result.php?tc=1.A.27.3
UCSC	uc002nyg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002nyg&org=rat
UniGene	Hs.333418	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.333418
UniProtKB	FXYD5_HUMAN	http://www.uniprot.org/uniprot/FXYD5_HUMAN
UniProtKB-AC	Q96DB9	http://www.uniprot.org/uniprot/Q96DB9
charge	swissprot:FXYD5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:FXYD5_HUMAN
eggNOG	ENOG410JCU8	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410JCU8
eggNOG	ENOG4111E7R	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111E7R
epestfind	swissprot:FXYD5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:FXYD5_HUMAN
garnier	swissprot:FXYD5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:FXYD5_HUMAN
helixturnhelix	swissprot:FXYD5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:FXYD5_HUMAN
hmoment	swissprot:FXYD5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:FXYD5_HUMAN
iep	swissprot:FXYD5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:FXYD5_HUMAN
inforesidue	swissprot:FXYD5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:FXYD5_HUMAN
neXtProt	NX_Q96DB9	http://www.nextprot.org/db/entry/NX_Q96DB9
octanol	swissprot:FXYD5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:FXYD5_HUMAN
pepcoil	swissprot:FXYD5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:FXYD5_HUMAN
pepdigest	swissprot:FXYD5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:FXYD5_HUMAN
pepinfo	swissprot:FXYD5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:FXYD5_HUMAN
pepnet	swissprot:FXYD5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:FXYD5_HUMAN
pepstats	swissprot:FXYD5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:FXYD5_HUMAN
pepwheel	swissprot:FXYD5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:FXYD5_HUMAN
pepwindow	swissprot:FXYD5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:FXYD5_HUMAN
sigcleave	swissprot:FXYD5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:FXYD5_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	EAA5_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O00341-1; Sequence=Displayed; Name=2; IsoId=O00341-2; Sequence=VSP_056560, VSP_056561; Note=No experimental confirmation available.; 
# AltName	EAA5_HUMAN	Retinal glutamate transporter
# AltName	EAA5_HUMAN	Solute carrier family 1 member 7
# BioGrid	112403	2
# CCDS	CCDS574	-. [O00341-1]
# CCDS	CCDS72798	-. [O00341-2]
# Ensembl	ENST00000371491	ENSP00000360546; ENSG00000162383. [O00341-2]
# Ensembl	ENST00000371494	ENSP00000360549; ENSG00000162383. [O00341-1]
# ExpressionAtlas	O00341	baseline and differential
# FUNCTION	EAA5_HUMAN	Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate in visual processing. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005313	L-glutamate transmembrane transporter activity; TAS:UniProtKB.
# GO_function	GO:0005314	high-affinity glutamate transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006835	dicarboxylic acid transport; TAS:UniProtKB.
# GO_process	GO:0014047	glutamate secretion; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Gene3D	1.10.3860.10	-; 2.
# Genevisible	O00341	HS
# HGNC	HGNC:10945	SLC1A7
# InterPro	IPR001991	Na-dicarboxylate_symporter
# InterPro	IPR018107	Na-dicarboxylate_symporter_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04724	Glutamatergic synapse
# MIM	604471	gene
# Organism	EAA5_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11958	PTHR11958; 3
# PRINTS	PR00173	EDTRNSPORT
# PROSITE	PS00713	NA_DICARBOXYL_SYMP_1
# PROSITE	PS00714	NA_DICARBOXYL_SYMP_2
# Pfam	PF00375	SDF
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-210500	Glutamate Neurotransmitter Release Cycle
# Reactome	R-HSA-425393	Transport of inorganic cations/anions and amino acids/oligopeptides
# RecName	EAA5_HUMAN	Excitatory amino acid transporter 5
# RefSeq	NP_001274525	NM_001287596.1. [O00341-2]
# RefSeq	NP_001274526	NM_001287597.1
# RefSeq	NP_006662	NM_006671.5. [O00341-1]
# SIMILARITY	Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A7 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	EAA5_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	EAA5_HUMAN	Interacts with the PDZ domains of DLG4. 
# SUPFAM	SSF118215	SSF118215; 2
# TCDB	2.A.23.2:the dicarboxylate/amino acid	cation (na(+) or h(+)) symporter (daacs) family
# TISSUE SPECIFICITY	EAA5_HUMAN	Expressed primarily in retina. Detectable in liver, heart, muscle and brain. 
# UCSC	uc001cuy	human. [O00341-1]
# eggNOG	COG1301	LUCA
# eggNOG	KOG3787	Eukaryota
BLAST	swissprot:EAA5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:EAA5_HUMAN
BioCyc	ZFISH:ENSG00000162383-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000162383-MONOMER
COXPRESdb	6512	http://coxpresdb.jp/data/gene/6512.shtml
CleanEx	HS_SLC1A7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC1A7
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1073/pnas.94.8.4155	http://dx.doi.org/10.1073/pnas.94.8.4155
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
EMBL	AL445183	http://www.ebi.ac.uk/ena/data/view/AL445183
EMBL	BC000651	http://www.ebi.ac.uk/ena/data/view/BC000651
EMBL	BC012119	http://www.ebi.ac.uk/ena/data/view/BC012119
EMBL	BC017242	http://www.ebi.ac.uk/ena/data/view/BC017242
EMBL	CH471059	http://www.ebi.ac.uk/ena/data/view/CH471059
EMBL	CH471059	http://www.ebi.ac.uk/ena/data/view/CH471059
EMBL	U76362	http://www.ebi.ac.uk/ena/data/view/U76362
Ensembl	ENST00000371491	http://www.ensembl.org/id/ENST00000371491
Ensembl	ENST00000371494	http://www.ensembl.org/id/ENST00000371494
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005313	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005313
GO_function	GO:0005314	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005314
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006835	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006835
GO_process	GO:0014047	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014047
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
Gene3D	1.10.3860.10	http://www.cathdb.info/version/latest/superfamily/1.10.3860.10
GeneCards	SLC1A7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC1A7
GeneID	6512	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6512
GeneTree	ENSGT00760000119117	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119117
H-InvDB	HIX0000592	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0000592
H-InvDB	HIX0159667	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0159667
HGNC	HGNC:10945	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10945
HOGENOM	HOG000208776	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000208776&db=HOGENOM6
HOVERGEN	HBG000080	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000080&db=HOVERGEN
HPA	HPA049124	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA049124
InParanoid	O00341	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O00341
IntAct	O00341	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O00341*
InterPro	IPR001991	http://www.ebi.ac.uk/interpro/entry/IPR001991
InterPro	IPR018107	http://www.ebi.ac.uk/interpro/entry/IPR018107
Jabion	6512	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6512
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6512	http://www.genome.jp/dbget-bin/www_bget?hsa:6512
KEGG_Orthology	KO:K05618	http://www.genome.jp/dbget-bin/www_bget?KO:K05618
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
MIM	604471	http://www.ncbi.nlm.nih.gov/omim/604471
PANTHER	PTHR11958	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11958
PRINTS	PR00173	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00173
PROSITE	PS00713	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00713
PROSITE	PS00714	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00714
PSORT	swissprot:EAA5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:EAA5_HUMAN
PSORT-B	swissprot:EAA5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:EAA5_HUMAN
PSORT2	swissprot:EAA5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:EAA5_HUMAN
Pfam	PF00375	http://pfam.xfam.org/family/PF00375
PharmGKB	PA35832	http://www.pharmgkb.org/do/serve?objId=PA35832&objCls=Gene
Phobius	swissprot:EAA5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:EAA5_HUMAN
PhylomeDB	O00341	http://phylomedb.org/?seqid=O00341
ProteinModelPortal	O00341	http://www.proteinmodelportal.org/query/uniprot/O00341
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	9108121	http://www.ncbi.nlm.nih.gov/pubmed/9108121
Reactome	R-HSA-210500	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-210500
Reactome	R-HSA-425393	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425393
RefSeq	NP_001274525	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001274525
RefSeq	NP_001274526	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001274526
RefSeq	NP_006662	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006662
STRING	9606.ENSP00000360549	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000360549&targetmode=cogs
SUPFAM	SSF118215	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF118215
TCDB	2.A.23.2	http://www.tcdb.org/search/result.php?tc=2.A.23.2
UCSC	uc001cuy	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001cuy&org=rat
UniGene	Hs.104637	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.104637
UniProtKB	EAA5_HUMAN	http://www.uniprot.org/uniprot/EAA5_HUMAN
UniProtKB-AC	O00341	http://www.uniprot.org/uniprot/O00341
charge	swissprot:EAA5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:EAA5_HUMAN
eggNOG	COG1301	http://eggnogapi.embl.de/nog_data/html/tree/COG1301
eggNOG	KOG3787	http://eggnogapi.embl.de/nog_data/html/tree/KOG3787
epestfind	swissprot:EAA5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:EAA5_HUMAN
garnier	swissprot:EAA5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:EAA5_HUMAN
helixturnhelix	swissprot:EAA5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:EAA5_HUMAN
hmoment	swissprot:EAA5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:EAA5_HUMAN
iep	swissprot:EAA5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:EAA5_HUMAN
inforesidue	swissprot:EAA5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:EAA5_HUMAN
neXtProt	NX_O00341	http://www.nextprot.org/db/entry/NX_O00341
octanol	swissprot:EAA5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:EAA5_HUMAN
pepcoil	swissprot:EAA5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:EAA5_HUMAN
pepdigest	swissprot:EAA5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:EAA5_HUMAN
pepinfo	swissprot:EAA5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:EAA5_HUMAN
pepnet	swissprot:EAA5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:EAA5_HUMAN
pepstats	swissprot:EAA5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:EAA5_HUMAN
pepwheel	swissprot:EAA5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:EAA5_HUMAN
pepwindow	swissprot:EAA5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:EAA5_HUMAN
sigcleave	swissprot:EAA5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:EAA5_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GPHRA_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=B7ZAQ6-1; Sequence=Displayed; Name=2; IsoId=B7ZAQ6-2; Sequence=VSP_017247; Name=3; IsoId=B7ZAQ6-3; Sequence=VSP_039346; Name=4; Synonyms=A; IsoId=B7ZAQ6-4; Sequence=VSP_055892, VSP_055893; 
# AltName	GPHRA_HUMAN	Protein GPR89A
# AltName	GPHRA_HUMAN	Putative MAPK-activating protein PM01
# AltName	GPHRA_HUMAN	Putative NF-kappa-B-activating protein 90
# BioGrid	119554	16
# BioGrid	575849	36
# CCDS	CCDS72857	-. [B7ZAQ6-1]
# CCDS	CCDS72858	-. [B7ZAQ6-3]
# ChiTaRS	GPR89A	human
# Ensembl	ENST00000313835	ENSP00000319673; ENSG00000117262. [B7ZAQ6-1]
# Ensembl	ENST00000460277	ENSP00000436705; ENSG00000117262. [B7ZAQ6-4]
# Ensembl	ENST00000462900	ENSP00000432248; ENSG00000117262. [B7ZAQ6-3]
# Ensembl	ENST00000528944	ENSP00000434108; ENSG00000117262. [B7ZAQ6-4]
# Ensembl	ENST00000534502	ENSP00000434495; ENSG00000117262. [B7ZAQ6-3]
# ExpressionAtlas	B7ZAQ6	baseline and differential
# FUNCTION	GPHRA_HUMAN	Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance. {ECO 0000250, ECO 0000269|PubMed 12761501, ECO 0000269|PubMed 18794847}. 
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0030660	Golgi-associated vesicle membrane; IDA:UniProtKB.
# GO_component	GO:0032580	Golgi cisterna membrane; IDA:UniProtKB.
# GO_function	GO:0004871	signal transducer activity; IMP:UniProtKB.
# GO_function	GO:0008308	voltage-gated anion channel activity; IDA:UniProtKB.
# GO_process	GO:0015031	protein transport; IEA:UniProtKB-KW.
# GO_process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB.
# GO_process	GO:0051452	intracellular pH reduction; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# Genevisible	B7ZAQ6	HS
# HGNC	HGNC:31984	GPR89A
# IntAct	B7ZAQ6	5
# InterPro	IPR015672	GPHR/GTG
# InterPro	IPR022535	Golgi_pH-regulator_cons_dom
# InterPro	IPR025969	ABA_GPCR_dom
# MIM	612821	gene
# MISCELLANEOUS	GPHRA_HUMAN	Does not seem to be able to bind GTP. 
# Organism	GPHRA_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR15948	PTHR15948
# Pfam	PF12430	ABA_GPCR
# Pfam	PF12537	GPHR_N
# Proteomes	UP000005640	Chromosome 1
# RecName	GPHRA_HUMAN	Golgi pH regulator A
# RefSeq	NP_001091081	NM_001097612.1. [B7ZAQ6-1]
# RefSeq	NP_001091082	NM_001097613.2. [B7ZAQ6-3]
# RefSeq	NP_057418	NM_016334.3. [B7ZAQ6-1]
# RefSeq	XP_005277458	XM_005277401.3. [B7ZAQ6-1]
# RefSeq	XP_005277459	XM_005277402.4. [B7ZAQ6-3]
# RefSeq	XP_005277461	XM_005277404.3. [B7ZAQ6-2]
# RefSeq	XP_006711440	XM_006711377.3. [B7ZAQ6-3]
# RefSeq	XP_006711441	XM_006711378.2. [B7ZAQ6-2]
# RefSeq	XP_006711555	XM_006711492.3. [B7ZAQ6-1]
# RefSeq	XP_006711556	XM_006711493.3. [B7ZAQ6-2]
# RefSeq	XP_011507912	XM_011509610.2. [B7ZAQ6-3]
# RefSeq	XP_011507914	XM_011509612.2. [B7ZAQ6-2]
# RefSeq	XP_011508210	XM_011509908.2. [B7ZAQ6-3]
# RefSeq	XP_011508211	XM_011509909.2. [B7ZAQ6-3]
# RefSeq	XP_016856937	XM_017001448.1. [B7ZAQ6-3]
# SIMILARITY	Belongs to the Golgi pH regulator (TC 1.A.38) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	GPHRA_HUMAN	Golgi apparatus membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUBUNIT	Homotrimer. {ECO	0000250}. 
# TISSUE SPECIFICITY	Ubiquitous. {ECO:0000269|PubMed	18794847}. 
# UCSC	uc010ozb	human. [B7ZAQ6-1]
# eggNOG	ENOG410XQ8R	LUCA
# eggNOG	KOG2417	Eukaryota
BLAST	swissprot:GPHRA_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GPHRA_HUMAN
COXPRESdb	51463	http://coxpresdb.jp/data/gene/51463.shtml
COXPRESdb	653519	http://coxpresdb.jp/data/gene/653519.shtml
DOI	10.1016/j.cell.2008.12.026	http://dx.doi.org/10.1016/j.cell.2008.12.026
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ncb1773	http://dx.doi.org/10.1038/ncb1773
DOI	10.1038/ncomms4650	http://dx.doi.org/10.1038/ncomms4650
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.onc.1206406	http://dx.doi.org/10.1038/sj.onc.1206406
DOI	10.1101/gr.10.5.703	http://dx.doi.org/10.1101/gr.10.5.703
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB097024	http://www.ebi.ac.uk/ena/data/view/AB097024
EMBL	AB097025	http://www.ebi.ac.uk/ena/data/view/AB097025
EMBL	AF132947	http://www.ebi.ac.uk/ena/data/view/AF132947
EMBL	AK021758	http://www.ebi.ac.uk/ena/data/view/AK021758
EMBL	AK223223	http://www.ebi.ac.uk/ena/data/view/AK223223
EMBL	AK297145	http://www.ebi.ac.uk/ena/data/view/AK297145
EMBL	AK301939	http://www.ebi.ac.uk/ena/data/view/AK301939
EMBL	AK316371	http://www.ebi.ac.uk/ena/data/view/AK316371
EMBL	AL390725	http://www.ebi.ac.uk/ena/data/view/AL390725
EMBL	AL390725	http://www.ebi.ac.uk/ena/data/view/AL390725
EMBL	AL390725	http://www.ebi.ac.uk/ena/data/view/AL390725
EMBL	AY358966	http://www.ebi.ac.uk/ena/data/view/AY358966
EMBL	BC003187	http://www.ebi.ac.uk/ena/data/view/BC003187
EMBL	BC067816	http://www.ebi.ac.uk/ena/data/view/BC067816
EMBL	BC146880	http://www.ebi.ac.uk/ena/data/view/BC146880
EMBL	BT006679	http://www.ebi.ac.uk/ena/data/view/BT006679
EMBL	BX511042	http://www.ebi.ac.uk/ena/data/view/BX511042
EMBL	BX511042	http://www.ebi.ac.uk/ena/data/view/BX511042
EMBL	BX511042	http://www.ebi.ac.uk/ena/data/view/BX511042
EMBL	CR628408	http://www.ebi.ac.uk/ena/data/view/CR628408
EMBL	CR628408	http://www.ebi.ac.uk/ena/data/view/CR628408
EMBL	CR628408	http://www.ebi.ac.uk/ena/data/view/CR628408
EMBL	KJ535049	http://www.ebi.ac.uk/ena/data/view/KJ535049
Ensembl	ENST00000313835	http://www.ensembl.org/id/ENST00000313835
Ensembl	ENST00000460277	http://www.ensembl.org/id/ENST00000460277
Ensembl	ENST00000462900	http://www.ensembl.org/id/ENST00000462900
Ensembl	ENST00000528944	http://www.ensembl.org/id/ENST00000528944
Ensembl	ENST00000534502	http://www.ensembl.org/id/ENST00000534502
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030660	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030660
GO_component	GO:0032580	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032580
GO_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GO_function	GO:0008308	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008308
GO_process	GO:0015031	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031
GO_process	GO:0043123	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043123
GO_process	GO:0051452	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051452
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GeneCards	GPR89A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GPR89A
GeneID	51463	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51463
GeneID	653519	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=653519
GeneTree	ENSGT00390000000684	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000000684
HGNC	HGNC:31984	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:31984
HOVERGEN	HBG054909	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054909&db=HOVERGEN
HPA	CAB068193	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB068193
InParanoid	B7ZAQ6	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=B7ZAQ6
IntAct	B7ZAQ6	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=B7ZAQ6*
InterPro	IPR015672	http://www.ebi.ac.uk/interpro/entry/IPR015672
InterPro	IPR022535	http://www.ebi.ac.uk/interpro/entry/IPR022535
InterPro	IPR025969	http://www.ebi.ac.uk/interpro/entry/IPR025969
Jabion	51463	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=51463
Jabion	653519	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=653519
KEGG_Gene	hsa:51463	http://www.genome.jp/dbget-bin/www_bget?hsa:51463
KEGG_Gene	hsa:653519	http://www.genome.jp/dbget-bin/www_bget?hsa:653519
MIM	612821	http://www.ncbi.nlm.nih.gov/omim/612821
MINT	MINT-4723292	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4723292
PANTHER	PTHR15948	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15948
PSORT	swissprot:GPHRA_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GPHRA_HUMAN
PSORT-B	swissprot:GPHRA_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GPHRA_HUMAN
PSORT2	swissprot:GPHRA_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GPHRA_HUMAN
Pfam	PF12430	http://pfam.xfam.org/family/PF12430
Pfam	PF12537	http://pfam.xfam.org/family/PF12537
PharmGKB	PA134986137	http://www.pharmgkb.org/do/serve?objId=PA134986137&objCls=Gene
Phobius	swissprot:GPHRA_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GPHRA_HUMAN
PhylomeDB	B7ZAQ6	http://phylomedb.org/?seqid=B7ZAQ6
ProteinModelPortal	B7ZAQ6	http://www.proteinmodelportal.org/query/uniprot/B7ZAQ6
PubMed	10810093	http://www.ncbi.nlm.nih.gov/pubmed/10810093
PubMed	12761501	http://www.ncbi.nlm.nih.gov/pubmed/12761501
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	18794847	http://www.ncbi.nlm.nih.gov/pubmed/18794847
PubMed	19135895	http://www.ncbi.nlm.nih.gov/pubmed/19135895
PubMed	24722188	http://www.ncbi.nlm.nih.gov/pubmed/24722188
RefSeq	NP_001091081	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001091081
RefSeq	NP_001091082	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001091082
RefSeq	NP_057418	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_057418
RefSeq	XP_005277458	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005277458
RefSeq	XP_005277459	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005277459
RefSeq	XP_005277461	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005277461
RefSeq	XP_006711440	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006711440
RefSeq	XP_006711441	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006711441
RefSeq	XP_006711555	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006711555
RefSeq	XP_006711556	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006711556
RefSeq	XP_011507912	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011507912
RefSeq	XP_011507914	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011507914
RefSeq	XP_011508210	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011508210
RefSeq	XP_011508211	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011508211
RefSeq	XP_016856937	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016856937
STRING	9606.ENSP00000358233	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000358233&targetmode=cogs
UCSC	uc010ozb	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010ozb&org=rat
UniGene	Hs.504320	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.504320
UniGene	Hs.559115	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.559115
UniGene	Hs.645432	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.645432
UniGene	Hs.680770	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.680770
UniProtKB	GPHRA_HUMAN	http://www.uniprot.org/uniprot/GPHRA_HUMAN
UniProtKB-AC	B7ZAQ6	http://www.uniprot.org/uniprot/B7ZAQ6
charge	swissprot:GPHRA_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GPHRA_HUMAN
eggNOG	ENOG410XQ8R	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ8R
eggNOG	KOG2417	http://eggnogapi.embl.de/nog_data/html/tree/KOG2417
epestfind	swissprot:GPHRA_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GPHRA_HUMAN
garnier	swissprot:GPHRA_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GPHRA_HUMAN
helixturnhelix	swissprot:GPHRA_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GPHRA_HUMAN
hmoment	swissprot:GPHRA_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GPHRA_HUMAN
iep	swissprot:GPHRA_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GPHRA_HUMAN
inforesidue	swissprot:GPHRA_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GPHRA_HUMAN
neXtProt	NX_B7ZAQ6	http://www.nextprot.org/db/entry/NX_B7ZAQ6
octanol	swissprot:GPHRA_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GPHRA_HUMAN
pepcoil	swissprot:GPHRA_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GPHRA_HUMAN
pepdigest	swissprot:GPHRA_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GPHRA_HUMAN
pepinfo	swissprot:GPHRA_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GPHRA_HUMAN
pepnet	swissprot:GPHRA_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GPHRA_HUMAN
pepstats	swissprot:GPHRA_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GPHRA_HUMAN
pepwheel	swissprot:GPHRA_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GPHRA_HUMAN
pepwindow	swissprot:GPHRA_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GPHRA_HUMAN
sigcleave	swissprot:GPHRA_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GPHRA_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	NUPL2_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O15504-1; Sequence=Displayed; Name=2; IsoId=O15504-2; Sequence=VSP_016481, VSP_016482; Name=3; IsoId=O15504-3; Sequence=VSP_016480; 
# AltName	NUPL2_HUMAN	NLP-1
# AltName	NUPL2_HUMAN	NUP42 homolog
# AltName	NUPL2_HUMAN	Nucleoporin hCG1
# BioGrid	116278	22
# CCDS	CCDS5379	-. [O15504-1]
# ChiTaRS	NUPL2	human
# DOMAIN	NUPL2_HUMAN	The FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. {ECO 0000250}. 
# Ensembl	ENST00000258742	ENSP00000258742; ENSG00000136243. [O15504-1]
# Ensembl	ENST00000438012	ENSP00000415511; ENSG00000136243. [O15504-2]
# ExpressionAtlas	O15504	baseline and differential
# FUNCTION	NUPL2_HUMAN	Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope. {ECO 0000269|PubMed 10610322, ECO 0000269|PubMed 16000379}. 
# GO_component	GO:0005634	nucleus; IDA:GO_Central.
# GO_component	GO:0005643	nuclear pore; IEA:UniProtKB-SubCell.
# GO_component	GO:0005654	nucleoplasm; IDA:HPA.
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0031965	nuclear membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0005049	nuclear export signal receptor activity; IDA:GO_Central.
# GO_function	GO:0044822	poly(A) RNA binding; IDA:UniProtKB.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0006406	mRNA export from nucleus; TAS:Reactome.
# GO_process	GO:0006409	tRNA export from nucleus; TAS:Reactome.
# GO_process	GO:0006611	protein export from nucleus; IGI:GO_Central.
# GO_process	GO:0007077	mitotic nuclear envelope disassembly; TAS:Reactome.
# GO_process	GO:0010827	regulation of glucose transport; TAS:Reactome.
# GO_process	GO:0016032	viral process; TAS:Reactome.
# GO_process	GO:0016925	protein sumoylation; TAS:Reactome.
# GO_process	GO:0019083	viral transcription; TAS:Reactome.
# GO_process	GO:0031047	gene silencing by RNA; TAS:Reactome.
# GO_process	GO:0075733	intracellular transport of virus; TAS:Reactome.
# GO_process	GO:1900034	regulation of cellular response to heat; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003723	RNA binding
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# GOslim_process	GO:0061024	membrane organization
# Genevisible	O15504	HS
# HGNC	HGNC:17010	NUPL2
# IntAct	O15504	18
# InterPro	IPR000571	Znf_CCCH
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Pathway	ko03013	RNA transport
# Organism	NUPL2_HUMAN	Homo sapiens (Human)
# PROSITE	PS50103	ZF_C3H1
# PTM	NUPL2_HUMAN	O-glycosylated. {ECO 0000269|PubMed 10358091}. 
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-1169408	ISG15 antiviral mechanism
# Reactome	R-HSA-159227	Transport of the SLBP independent Mature mRNA
# Reactome	R-HSA-159230	Transport of the SLBP Dependant Mature mRNA
# Reactome	R-HSA-159231	Transport of Mature mRNA Derived from an Intronless Transcript
# Reactome	R-HSA-159236	Transport of Mature mRNA derived from an Intron-Containing Transcript
# Reactome	R-HSA-165054	Rev-mediated nuclear export of HIV RNA
# Reactome	R-HSA-168271	Transport of Ribonucleoproteins into the Host Nucleus
# Reactome	R-HSA-168276	NS1 Mediated Effects on Host Pathways
# Reactome	R-HSA-168325	Viral Messenger RNA Synthesis
# Reactome	R-HSA-168333	NEP/NS2 Interacts with the Cellular Export Machinery
# Reactome	R-HSA-170822	Regulation of Glucokinase by Glucokinase Regulatory Protein
# Reactome	R-HSA-180746	Nuclear import of Rev protein
# Reactome	R-HSA-180910	Vpr-mediated nuclear import of PICs
# Reactome	R-HSA-191859	snRNP Assembly
# Reactome	R-HSA-3108214	SUMOylation of DNA damage response and repair proteins
# Reactome	R-HSA-3301854	Nuclear Pore Complex (NPC) Disassembly
# Reactome	R-HSA-3371453	Regulation of HSF1-mediated heat shock response
# Reactome	R-HSA-4570464	SUMOylation of RNA binding proteins
# Reactome	R-HSA-4615885	SUMOylation of DNA replication proteins
# Reactome	R-HSA-5578749	Transcriptional regulation by small RNAs
# Reactome	R-HSA-6784531	tRNA processing in the nucleus
# RecName	NUPL2_HUMAN	Nucleoporin-like protein 2
# RefSeq	NP_031368	NM_007342.2. [O15504-1]
# SIMILARITY	Contains 1 C3H1-type zinc finger. {ECO:0000255|PROSITE-ProRule	PRU00723}.
# SMART	SM00356	ZnF_C3H1
# SUBCELLULAR LOCATION	NUPL2_HUMAN	Nucleus, nuclear pore complex {ECO 0000269|PubMed 12228227, ECO 0000269|PubMed 16000379}. Nucleus membrane {ECO 0000269|PubMed 12228227, ECO 0000269|PubMed 16000379}; Peripheral membrane protein; Cytoplasmic side {ECO 0000269|PubMed 12228227}. Note=Excluded from the nucleolus. {ECO 0000269|PubMed 10358091}. 
# SUBUNIT	NUPL2_HUMAN	Probable component of the nuclear pore complex (NPC). Interacts with nuclear export protein NXF1. Interacts with GLE1. Able to form a heterotrimer with NUP155 and GLE1 in vitro. Interacts with the HIV-1 virus proteins Rev and Vpr. The interaction with HIV-1 Rev, a protein that mediates nuclear export of unspliced viral RNAs, suggests that its function may be bypassed by the HIV-1 virus. {ECO 0000269|PubMed 10228171, ECO 0000269|PubMed 10358091, ECO 0000269|PubMed 12228227, ECO 0000269|PubMed 16000379}. 
# TCDB	1.I.1.1	the nuclear pore complex (npc) family
# TISSUE SPECIFICITY	Ubiquitously expressed. {ECO:0000269|PubMed	10358091}. 
# UCSC	uc003svu	human. [O15504-1]
# eggNOG	ENOG410IIH3	Eukaryota
# eggNOG	ENOG4111HKJ	LUCA
BLAST	swissprot:NUPL2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NUPL2_HUMAN
COXPRESdb	11097	http://coxpresdb.jp/data/gene/11097.shtml
CleanEx	HS_NUPL2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_NUPL2
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/jbc.274.24.17309	http://dx.doi.org/10.1074/jbc.274.24.17309
DOI	10.1074/jbc.M207439200	http://dx.doi.org/10.1074/jbc.M207439200
DOI	10.1091/mbc.E04-11-0998	http://dx.doi.org/10.1091/mbc.E04-11-0998
DOI	10.1093/emboj/18.20.5761	http://dx.doi.org/10.1093/emboj/18.20.5761
DOI	10.1093/emboj/18.9.2593	http://dx.doi.org/10.1093/emboj/18.9.2593
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1083423	http://dx.doi.org/10.1126/science.1083423
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
EMBL	AK298183	http://www.ebi.ac.uk/ena/data/view/AK298183
EMBL	BC005327	http://www.ebi.ac.uk/ena/data/view/BC005327
EMBL	BC039333	http://www.ebi.ac.uk/ena/data/view/BC039333
EMBL	BT007409	http://www.ebi.ac.uk/ena/data/view/BT007409
EMBL	CH236948	http://www.ebi.ac.uk/ena/data/view/CH236948
EMBL	U97198	http://www.ebi.ac.uk/ena/data/view/U97198
Ensembl	ENST00000258742	http://www.ensembl.org/id/ENST00000258742
Ensembl	ENST00000438012	http://www.ensembl.org/id/ENST00000438012
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005643	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005643
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0031965	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031965
GO_function	GO:0005049	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005049
GO_function	GO:0044822	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044822
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006406	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006406
GO_process	GO:0006409	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006409
GO_process	GO:0006611	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006611
GO_process	GO:0007077	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007077
GO_process	GO:0010827	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010827
GO_process	GO:0016032	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016032
GO_process	GO:0016925	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016925
GO_process	GO:0019083	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019083
GO_process	GO:0031047	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031047
GO_process	GO:0075733	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0075733
GO_process	GO:1900034	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900034
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003723	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
GeneCards	NUPL2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=NUPL2
GeneID	11097	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11097
GeneTree	ENSGT00390000000118	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000000118
HGNC	HGNC:17010	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17010
HOGENOM	HOG000113895	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000113895&db=HOGENOM6
HOVERGEN	HBG082070	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG082070&db=HOVERGEN
HPA	HPA049036	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA049036
HPA	HPA057251	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA057251
InParanoid	O15504	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O15504
IntAct	O15504	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O15504*
InterPro	IPR000571	http://www.ebi.ac.uk/interpro/entry/IPR000571
Jabion	11097	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=11097
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Gene	hsa:11097	http://www.genome.jp/dbget-bin/www_bget?hsa:11097
KEGG_Orthology	KO:K14321	http://www.genome.jp/dbget-bin/www_bget?KO:K14321
KEGG_Pathway	ko03013	http://www.genome.jp/kegg-bin/show_pathway?ko03013
MINT	MINT-4786853	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4786853
PROSITE	PS50103	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50103
PSORT	swissprot:NUPL2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NUPL2_HUMAN
PSORT-B	swissprot:NUPL2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NUPL2_HUMAN
PSORT2	swissprot:NUPL2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NUPL2_HUMAN
PharmGKB	PA134990469	http://www.pharmgkb.org/do/serve?objId=PA134990469&objCls=Gene
Phobius	swissprot:NUPL2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NUPL2_HUMAN
PhylomeDB	O15504	http://phylomedb.org/?seqid=O15504
ProteinModelPortal	O15504	http://www.proteinmodelportal.org/query/uniprot/O15504
PubMed	10228171	http://www.ncbi.nlm.nih.gov/pubmed/10228171
PubMed	10358091	http://www.ncbi.nlm.nih.gov/pubmed/10358091
PubMed	10610322	http://www.ncbi.nlm.nih.gov/pubmed/10610322
PubMed	12228227	http://www.ncbi.nlm.nih.gov/pubmed/12228227
PubMed	12690205	http://www.ncbi.nlm.nih.gov/pubmed/12690205
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16000379	http://www.ncbi.nlm.nih.gov/pubmed/16000379
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	9450185	http://www.ncbi.nlm.nih.gov/pubmed/9450185
Reactome	R-HSA-1169408	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1169408
Reactome	R-HSA-159227	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-159227
Reactome	R-HSA-159230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-159230
Reactome	R-HSA-159231	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-159231
Reactome	R-HSA-159236	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-159236
Reactome	R-HSA-165054	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-165054
Reactome	R-HSA-168271	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-168271
Reactome	R-HSA-168276	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-168276
Reactome	R-HSA-168325	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-168325
Reactome	R-HSA-168333	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-168333
Reactome	R-HSA-170822	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-170822
Reactome	R-HSA-180746	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-180746
Reactome	R-HSA-180910	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-180910
Reactome	R-HSA-191859	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-191859
Reactome	R-HSA-3108214	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3108214
Reactome	R-HSA-3301854	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3301854
Reactome	R-HSA-3371453	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3371453
Reactome	R-HSA-4570464	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-4570464
Reactome	R-HSA-4615885	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-4615885
Reactome	R-HSA-5578749	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578749
Reactome	R-HSA-6784531	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6784531
RefSeq	NP_031368	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_031368
SMART	SM00356	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00356
SMR	O15504	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O15504
STRING	9606.ENSP00000258742	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000258742&targetmode=cogs
TCDB	1.I.1.1	http://www.tcdb.org/search/result.php?tc=1.I.1.1
UCSC	uc003svu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003svu&org=rat
UniGene	Hs.408241	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.408241
UniProtKB	NUPL2_HUMAN	http://www.uniprot.org/uniprot/NUPL2_HUMAN
UniProtKB-AC	O15504	http://www.uniprot.org/uniprot/O15504
charge	swissprot:NUPL2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NUPL2_HUMAN
eggNOG	ENOG410IIH3	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IIH3
eggNOG	ENOG4111HKJ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111HKJ
epestfind	swissprot:NUPL2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NUPL2_HUMAN
garnier	swissprot:NUPL2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NUPL2_HUMAN
helixturnhelix	swissprot:NUPL2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NUPL2_HUMAN
hmoment	swissprot:NUPL2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NUPL2_HUMAN
iep	swissprot:NUPL2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NUPL2_HUMAN
inforesidue	swissprot:NUPL2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NUPL2_HUMAN
neXtProt	NX_O15504	http://www.nextprot.org/db/entry/NX_O15504
octanol	swissprot:NUPL2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NUPL2_HUMAN
pepcoil	swissprot:NUPL2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NUPL2_HUMAN
pepdigest	swissprot:NUPL2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NUPL2_HUMAN
pepinfo	swissprot:NUPL2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NUPL2_HUMAN
pepnet	swissprot:NUPL2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NUPL2_HUMAN
pepstats	swissprot:NUPL2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NUPL2_HUMAN
pepwheel	swissprot:NUPL2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NUPL2_HUMAN
pepwindow	swissprot:NUPL2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NUPL2_HUMAN
sigcleave	swissprot:NUPL2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NUPL2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S22AF_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8IZD6-1; Sequence=Displayed; Name=2; IsoId=Q8IZD6-2; Sequence=VSP_034059, VSP_034060; 
# AltName	S22AF_HUMAN	Fly-like putative transporter 1
# CCDS	CCDS44198	-. [Q8IZD6-1]
# CDD	cd06174	MFS
# DEVELOPMENTAL STAGE	Expressed at low levels at 20-25 weeks of gestation in fetal brain, lung, liver and kidney. {ECO:0000269|PubMed	12372408}. 
# Ensembl	ENST00000369502	ENSP00000358514; ENSG00000163393. [Q8IZD6-2]
# Ensembl	ENST00000369503	ENSP00000358515; ENSG00000163393. [Q8IZD6-1]
# FUNCTION	S22AF_HUMAN	Probably transports organic cations (By similarity). Appears not to be the agmatine transporter. {ECO 0000250, ECO 0000269|PubMed 15028572}. 
# GO_component	GO:0016021	integral component of membrane; IBA:GO_Central.
# GO_function	GO:0022891	substrate-specific transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0006811	ion transport; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q8IZD6	HS
# HGNC	HGNC:20301	SLC22A15
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	608275	gene
# Organism	S22AF_HUMAN	Homo sapiens (Human)
# PIR	T48683	T48683
# PROSITE	PS50850	MFS
# Pfam	PF00083	Sugar_tr
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-549127	Organic cation transport
# RecName	S22AF_HUMAN	Solute carrier family 22 member 15
# RefSeq	NP_060890	NM_018420.2. [Q8IZD6-1]
# SEQUENCE CAUTION	Sequence=AAH26358.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH26358.1; Type=Frameshift; Positions=7; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S22AF_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.19.32	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	S22AF_HUMAN	Expressed at highest levels in kidney and brain. Expressed at high levels in skeletal muscle, heart, liver, placenta and white blood cells. Expressed at moderate levels in lung and spleen. Expressed at low levels in thymus, small intestine and colon. Expressed in several intestinal tumor cell lines. {ECO 0000269|PubMed 12372408, ECO 0000269|PubMed 15028572}. 
# UCSC	uc001ega	human. [Q8IZD6-1]
# eggNOG	ENOG410IRI2	Eukaryota
# eggNOG	ENOG4110YHH	LUCA
BLAST	swissprot:S22AF_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S22AF_HUMAN
COXPRESdb	55356	http://coxpresdb.jp/data/gene/55356.shtml
CleanEx	HS_SLC22A15	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC22A15
DOI	10.1016/S0006-291X(02)02343-4	http://dx.doi.org/10.1016/S0006-291X(02)02343-4
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.1196/annals.1304.008	http://dx.doi.org/10.1196/annals.1304.008
EMBL	AL353933	http://www.ebi.ac.uk/ena/data/view/AL353933
EMBL	AL357137	http://www.ebi.ac.uk/ena/data/view/AL357137
EMBL	AL357137	http://www.ebi.ac.uk/ena/data/view/AL357137
EMBL	AL357137	http://www.ebi.ac.uk/ena/data/view/AL357137
EMBL	AL357137	http://www.ebi.ac.uk/ena/data/view/AL357137
EMBL	AL365318	http://www.ebi.ac.uk/ena/data/view/AL365318
EMBL	AL365318	http://www.ebi.ac.uk/ena/data/view/AL365318
EMBL	AL365318	http://www.ebi.ac.uk/ena/data/view/AL365318
EMBL	AL365318	http://www.ebi.ac.uk/ena/data/view/AL365318
EMBL	AY145501	http://www.ebi.ac.uk/ena/data/view/AY145501
EMBL	AY358258	http://www.ebi.ac.uk/ena/data/view/AY358258
EMBL	BC026358	http://www.ebi.ac.uk/ena/data/view/BC026358
EMBL	CH471122	http://www.ebi.ac.uk/ena/data/view/CH471122
Ensembl	ENST00000369502	http://www.ensembl.org/id/ENST00000369502
Ensembl	ENST00000369503	http://www.ensembl.org/id/ENST00000369503
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0022891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022891
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC22A15	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC22A15
GeneID	55356	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55356
GeneTree	ENSGT00860000133730	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00860000133730
HGNC	HGNC:20301	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20301
HOGENOM	HOG000234568	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234568&db=HOGENOM6
HOVERGEN	HBG108435	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108435&db=HOVERGEN
HPA	HPA019785	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA019785
InParanoid	Q8IZD6	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8IZD6
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	55356	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55356
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:55356	http://www.genome.jp/dbget-bin/www_bget?hsa:55356
KEGG_Orthology	KO:K08211	http://www.genome.jp/dbget-bin/www_bget?KO:K08211
MIM	608275	http://www.ncbi.nlm.nih.gov/omim/608275
OMA	FATFEAT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FATFEAT
OrthoDB	EOG091G05DV	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05DV
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:S22AF_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S22AF_HUMAN
PSORT-B	swissprot:S22AF_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S22AF_HUMAN
PSORT2	swissprot:S22AF_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S22AF_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
PharmGKB	PA134870374	http://www.pharmgkb.org/do/serve?objId=PA134870374&objCls=Gene
Phobius	swissprot:S22AF_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S22AF_HUMAN
PhylomeDB	Q8IZD6	http://phylomedb.org/?seqid=Q8IZD6
ProteinModelPortal	Q8IZD6	http://www.proteinmodelportal.org/query/uniprot/Q8IZD6
PubMed	12372408	http://www.ncbi.nlm.nih.gov/pubmed/12372408
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	15028572	http://www.ncbi.nlm.nih.gov/pubmed/15028572
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
Reactome	R-HSA-549127	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-549127
RefSeq	NP_060890	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060890
STRING	9606.ENSP00000358515	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000358515&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.19.32	http://www.tcdb.org/search/result.php?tc=2.A.1.19.32
UCSC	uc001ega	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001ega&org=rat
UniGene	Hs.125482	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.125482
UniProtKB	S22AF_HUMAN	http://www.uniprot.org/uniprot/S22AF_HUMAN
UniProtKB-AC	Q8IZD6	http://www.uniprot.org/uniprot/Q8IZD6
charge	swissprot:S22AF_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S22AF_HUMAN
eggNOG	ENOG410IRI2	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IRI2
eggNOG	ENOG4110YHH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110YHH
epestfind	swissprot:S22AF_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S22AF_HUMAN
garnier	swissprot:S22AF_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S22AF_HUMAN
helixturnhelix	swissprot:S22AF_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S22AF_HUMAN
hmoment	swissprot:S22AF_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S22AF_HUMAN
iep	swissprot:S22AF_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S22AF_HUMAN
inforesidue	swissprot:S22AF_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S22AF_HUMAN
neXtProt	NX_Q8IZD6	http://www.nextprot.org/db/entry/NX_Q8IZD6
octanol	swissprot:S22AF_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S22AF_HUMAN
pepcoil	swissprot:S22AF_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S22AF_HUMAN
pepdigest	swissprot:S22AF_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S22AF_HUMAN
pepinfo	swissprot:S22AF_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S22AF_HUMAN
pepnet	swissprot:S22AF_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S22AF_HUMAN
pepstats	swissprot:S22AF_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S22AF_HUMAN
pepwheel	swissprot:S22AF_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S22AF_HUMAN
pepwindow	swissprot:S22AF_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S22AF_HUMAN
sigcleave	swissprot:S22AF_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S22AF_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	XPO6_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96QU8-1; Sequence=Displayed; Name=2; IsoId=Q96QU8-2; Sequence=VSP_055756; 
# AltName	XPO6_HUMAN	Ran-binding protein 20
# BioGrid	116821	39
# CCDS	CCDS42135	-. [Q96QU8-1]
# CCDS	CCDS59266	-. [Q96QU8-2]
# ChiTaRS	XPO6	human
# Ensembl	ENST00000304658	ENSP00000302790; ENSG00000169180. [Q96QU8-1]
# Ensembl	ENST00000565698	ENSP00000457341; ENSG00000169180. [Q96QU8-2]
# ExpressionAtlas	Q96QU8	baseline and differential
# FUNCTION	XPO6_HUMAN	Mediates the nuclear export of actin and profilin-actin complexes in somatic cells. {ECO 0000269|PubMed 14592989}. 
# GO_component	GO:0005634	nucleus; IC:UniProtKB.
# GO_component	GO:0005730	nucleolus; IDA:HPA.
# GO_component	GO:0005737	cytoplasm; IC:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:HPA.
# GO_function	GO:0008565	protein transporter activity; IDA:UniProtKB.
# GO_process	GO:0006611	protein export from nucleus; IDA:UniProtKB.
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005730	nucleolus
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# Gene3D	1.25.10.10	-; 6.
# Genevisible	Q96QU8	HS
# HGNC	HGNC:19733	XPO6
# INTERACTION	XPO6_HUMAN	P37198 NUP62; NbExp=3; IntAct=EBI-10293124, EBI-347978; 
# IntAct	Q96QU8	4
# InterPro	IPR001494	Importin-beta_N
# InterPro	IPR011989	ARM-like
# InterPro	IPR013598	Exportin-1/Importin-b-like
# InterPro	IPR016024	ARM-type_fold
# MIM	608411	gene
# Organism	XPO6_HUMAN	Homo sapiens (Human)
# PROSITE	PS50166	IMPORTIN_B_NT
# Pfam	PF03810	IBN_N
# Pfam	PF08389	Xpo1
# Proteomes	UP000005640	Chromosome 16
# RecName	XPO6_HUMAN	Exportin-6
# RefSeq	NP_001257869	NM_001270940.1. [Q96QU8-2]
# RefSeq	NP_055986	NM_015171.3. [Q96QU8-1]
# SEQUENCE CAUTION	Sequence=BAA20825.3; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the exportin family. {ECO	0000305}. 
# SIMILARITY	Contains 1 importin N-terminal domain. {ECO:0000255|PROSITE-ProRule	PRU00115}. 
# SMART	SM00913	IBN_N
# SUBCELLULAR LOCATION	XPO6_HUMAN	Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. 
# SUBUNIT	Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with ACTB. Interacts with ACTB in a RanGTP-dependent manner. {ECO:0000269|PubMed	14592989}. 
# SUPFAM	SSF48371	SSF48371; 6
# UCSC	uc002dpa	human. [Q96QU8-1]
# eggNOG	COG5101	LUCA
# eggNOG	KOG2020	Eukaryota
BLAST	swissprot:XPO6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:XPO6_HUMAN
COXPRESdb	23214	http://coxpresdb.jp/data/gene/23214.shtml
CleanEx	HS_XPO6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_XPO6
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature03187	http://dx.doi.org/10.1038/nature03187
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1074/mcp.M111.015131	http://dx.doi.org/10.1074/mcp.M111.015131
DOI	10.1093/dnares/4.2.141	http://dx.doi.org/10.1093/dnares/4.2.141
DOI	10.1093/dnares/9.3.99	http://dx.doi.org/10.1093/dnares/9.3.99
DOI	10.1093/emboj/cdg565	http://dx.doi.org/10.1093/emboj/cdg565
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AB002368	http://www.ebi.ac.uk/ena/data/view/AB002368
EMBL	AC136611	http://www.ebi.ac.uk/ena/data/view/AC136611
EMBL	AK123846	http://www.ebi.ac.uk/ena/data/view/AK123846
EMBL	AK223043	http://www.ebi.ac.uk/ena/data/view/AK223043
EMBL	AY026388	http://www.ebi.ac.uk/ena/data/view/AY026388
EMBL	BC004403	http://www.ebi.ac.uk/ena/data/view/BC004403
EMBL	BC014071	http://www.ebi.ac.uk/ena/data/view/BC014071
EMBL	BC078674	http://www.ebi.ac.uk/ena/data/view/BC078674
EMBL	BC108286	http://www.ebi.ac.uk/ena/data/view/BC108286
EMBL	BC130304	http://www.ebi.ac.uk/ena/data/view/BC130304
EMBL	CH471145	http://www.ebi.ac.uk/ena/data/view/CH471145
EMBL	CH471145	http://www.ebi.ac.uk/ena/data/view/CH471145
EMBL	CH471145	http://www.ebi.ac.uk/ena/data/view/CH471145
Ensembl	ENST00000304658	http://www.ensembl.org/id/ENST00000304658
Ensembl	ENST00000565698	http://www.ensembl.org/id/ENST00000565698
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005730
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0006611	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006611
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005730
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
GeneCards	XPO6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=XPO6
GeneID	23214	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23214
GeneTree	ENSGT00390000002810	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002810
HGNC	HGNC:19733	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:19733
HOVERGEN	HBG054104	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054104&db=HOVERGEN
HPA	HPA038246	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA038246
InParanoid	Q96QU8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96QU8
IntAct	Q96QU8	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96QU8*
InterPro	IPR001494	http://www.ebi.ac.uk/interpro/entry/IPR001494
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR013598	http://www.ebi.ac.uk/interpro/entry/IPR013598
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
Jabion	23214	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=23214
KEGG_Gene	hsa:23214	http://www.genome.jp/dbget-bin/www_bget?hsa:23214
MIM	608411	http://www.ncbi.nlm.nih.gov/omim/608411
MINT	MINT-1452541	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1452541
OMA	EYVMMYS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EYVMMYS
OrthoDB	EOG091G040W	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G040W
PROSITE	PS50166	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50166
PSORT	swissprot:XPO6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:XPO6_HUMAN
PSORT-B	swissprot:XPO6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:XPO6_HUMAN
PSORT2	swissprot:XPO6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:XPO6_HUMAN
Pfam	PF03810	http://pfam.xfam.org/family/PF03810
Pfam	PF08389	http://pfam.xfam.org/family/PF08389
PharmGKB	PA134989996	http://www.pharmgkb.org/do/serve?objId=PA134989996&objCls=Gene
Phobius	swissprot:XPO6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:XPO6_HUMAN
PhylomeDB	Q96QU8	http://phylomedb.org/?seqid=Q96QU8
ProteinModelPortal	Q96QU8	http://www.proteinmodelportal.org/query/uniprot/Q96QU8
PubMed	12168954	http://www.ncbi.nlm.nih.gov/pubmed/12168954
PubMed	14592989	http://www.ncbi.nlm.nih.gov/pubmed/14592989
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15616553	http://www.ncbi.nlm.nih.gov/pubmed/15616553
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	22223895	http://www.ncbi.nlm.nih.gov/pubmed/22223895
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	9205841	http://www.ncbi.nlm.nih.gov/pubmed/9205841
RefSeq	NP_001257869	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001257869
RefSeq	NP_055986	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055986
SMART	SM00913	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00913
STRING	9606.ENSP00000302790	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000302790&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
UCSC	uc002dpa	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002dpa&org=rat
UniGene	Hs.460468	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.460468
UniProtKB	XPO6_HUMAN	http://www.uniprot.org/uniprot/XPO6_HUMAN
UniProtKB-AC	Q96QU8	http://www.uniprot.org/uniprot/Q96QU8
charge	swissprot:XPO6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:XPO6_HUMAN
eggNOG	COG5101	http://eggnogapi.embl.de/nog_data/html/tree/COG5101
eggNOG	KOG2020	http://eggnogapi.embl.de/nog_data/html/tree/KOG2020
epestfind	swissprot:XPO6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:XPO6_HUMAN
garnier	swissprot:XPO6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:XPO6_HUMAN
helixturnhelix	swissprot:XPO6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:XPO6_HUMAN
hmoment	swissprot:XPO6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:XPO6_HUMAN
iep	swissprot:XPO6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:XPO6_HUMAN
inforesidue	swissprot:XPO6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:XPO6_HUMAN
neXtProt	NX_Q96QU8	http://www.nextprot.org/db/entry/NX_Q96QU8
octanol	swissprot:XPO6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:XPO6_HUMAN
pepcoil	swissprot:XPO6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:XPO6_HUMAN
pepdigest	swissprot:XPO6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:XPO6_HUMAN
pepinfo	swissprot:XPO6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:XPO6_HUMAN
pepnet	swissprot:XPO6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:XPO6_HUMAN
pepstats	swissprot:XPO6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:XPO6_HUMAN
pepwheel	swissprot:XPO6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:XPO6_HUMAN
pepwindow	swissprot:XPO6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:XPO6_HUMAN
sigcleave	swissprot:XPO6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:XPO6_HUMAN
## Database	ID	URL or Descriptions
# AltName	S6A18_HUMAN	Sodium- and chloride-dependent transporter XTRP2
# AltName	S6A18_HUMAN	Solute carrier family 6 member 18
# AltName	S6A18_HUMAN	System B(0) neutral amino acid transporter AT3
# DISEASE	S6A18_HUMAN	Note=Genetic variations in SLC6A18 might contribute to the disease phentotype in some individuals with iminoglycinuria or hyperglycinuria, that carry variants in SLC36A2, SLC6A19 or SLC6A20 (PubMed 19033659). {ECO 0000269|PubMed 19033659}. 
# Ensembl	ENST00000324642	ENSP00000323549; ENSG00000164363
# FUNCTION	S6A18_HUMAN	Functions as a sodium and chloride-dependent neutral amino acid transporter. {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0031526	brush border membrane; IEA:Ensembl.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; IBA:GO_Central.
# GO_function	S6A18_HUMAN	GO 0005328 neurotransmitter sodium symporter activity; IEA InterPro.
# GO_process	GO:0006865	amino acid transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q96N87	HS
# HGNC	HGNC:26441	SLC6A18
# InterPro	IPR000175	Na/ntran_symport
# InterPro	IPR002438	Na/ntran_symport_orphan
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Brite	ko04040	 Ion channels
# MIM	610300	gene
# Organism	S6A18_HUMAN	Homo sapiens (Human)
# Orphanet	42062	Iminoglycinuria
# PANTHER	PTHR11616	PTHR11616; 2
# POLYMORPHISM	Genetic variation in SLC6A18 is not a significant predictor for elevated systolic or diastolic blood pressure and is not associated with hypertension in the Japanese population (PubMed:16340170). {ECO	0000269|PubMed:16340170}. 
# PRINTS	PR00176	NANEUSMPORT
# PRINTS	PR01206	ORPHTRNSPORT
# PROSITE	PS00610	NA_NEUROTRAN_SYMP_1
# PROSITE	PS00754	NA_NEUROTRAN_SYMP_2
# PROSITE	PS50267	NA_NEUROTRAN_SYMP_3
# Pfam	PF00209	SNF
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-352230	Amino acid transport across the plasma membrane
# Reactome	R-HSA-442660	Na+/Cl- dependent neurotransmitter transporters
# RecName	S6A18_HUMAN	Sodium-dependent neutral amino acid transporter B(0)AT3
# RefSeq	NP_872438	NM_182632.2
# SIMILARITY	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A18 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	S6A18_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUBUNIT	Associates with TMEM27. TMEM27 association is required for functional expression in kidney. {ECO	0000250}. 
# TCDB	2.A.22.6:the neurotransmitter	sodium symporter (nss) family
# TISSUE SPECIFICITY	Abundantly expressed in kidney, but not in intestine. {ECO:0000269|PubMed	15286787}. 
# UCSC	uc003jby	human
# eggNOG	COG0733	LUCA
# eggNOG	KOG3659	Eukaryota
BLAST	swissprot:S6A18_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S6A18_HUMAN
BioCyc	ZFISH:ENSG00000164363-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000164363-MONOMER
COXPRESdb	348932	http://coxpresdb.jp/data/gene/348932.shtml
CleanEx	HS_SLC6A18	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC6A18
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/ng1405	http://dx.doi.org/10.1038/ng1405
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1172/JCI36625	http://dx.doi.org/10.1172/JCI36625
DOI	10.1620/tjem.208.25	http://dx.doi.org/10.1620/tjem.208.25
EMBL	AC114291	http://www.ebi.ac.uk/ena/data/view/AC114291
EMBL	AK055798	http://www.ebi.ac.uk/ena/data/view/AK055798
EMBL	BC056757	http://www.ebi.ac.uk/ena/data/view/BC056757
Ensembl	ENST00000324642	http://www.ensembl.org/id/ENST00000324642
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0031526	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031526
GO_function	GO:0005328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005328
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC6A18	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC6A18
GeneID	348932	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=348932
GeneTree	ENSGT00760000119044	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119044
H-InvDB	HIX0004720	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0004720
HGNC	HGNC:26441	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:26441
HOGENOM	HOG000116406	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116406&db=HOGENOM6
HOVERGEN	HBG071421	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG071421&db=HOVERGEN
HPA	HPA011885	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA011885
InParanoid	Q96N87	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96N87
InterPro	IPR000175	http://www.ebi.ac.uk/interpro/entry/IPR000175
InterPro	IPR002438	http://www.ebi.ac.uk/interpro/entry/IPR002438
Jabion	348932	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=348932
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:348932	http://www.genome.jp/dbget-bin/www_bget?hsa:348932
KEGG_Orthology	KO:K05048	http://www.genome.jp/dbget-bin/www_bget?KO:K05048
MIM	610300	http://www.ncbi.nlm.nih.gov/omim/610300
MINT	MINT-4723009	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4723009
OMA	KLYPGWV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KLYPGWV
Orphanet	42062	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=42062
OrthoDB	EOG091G08PX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08PX
PANTHER	PTHR11616	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11616
PRINTS	PR00176	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00176
PRINTS	PR01206	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01206
PROSITE	PS00610	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00610
PROSITE	PS00754	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00754
PROSITE	PS50267	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50267
PSORT	swissprot:S6A18_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S6A18_HUMAN
PSORT-B	swissprot:S6A18_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S6A18_HUMAN
PSORT2	swissprot:S6A18_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S6A18_HUMAN
Pfam	PF00209	http://pfam.xfam.org/family/PF00209
PharmGKB	PA134982449	http://www.pharmgkb.org/do/serve?objId=PA134982449&objCls=Gene
Phobius	swissprot:S6A18_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S6A18_HUMAN
PhylomeDB	Q96N87	http://phylomedb.org/?seqid=Q96N87
ProteinModelPortal	Q96N87	http://www.proteinmodelportal.org/query/uniprot/Q96N87
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15286787	http://www.ncbi.nlm.nih.gov/pubmed/15286787
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16340170	http://www.ncbi.nlm.nih.gov/pubmed/16340170
PubMed	19033659	http://www.ncbi.nlm.nih.gov/pubmed/19033659
Reactome	R-HSA-352230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-352230
Reactome	R-HSA-442660	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442660
RefSeq	NP_872438	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_872438
SMR	Q96N87	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q96N87
STRING	9606.ENSP00000323549	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000323549&targetmode=cogs
TCDB	2.A.22.6	http://www.tcdb.org/search/result.php?tc=2.A.22.6
UCSC	uc003jby	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003jby&org=rat
UniGene	Hs.213284	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.213284
UniProtKB	S6A18_HUMAN	http://www.uniprot.org/uniprot/S6A18_HUMAN
UniProtKB-AC	Q96N87	http://www.uniprot.org/uniprot/Q96N87
charge	swissprot:S6A18_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S6A18_HUMAN
eggNOG	COG0733	http://eggnogapi.embl.de/nog_data/html/tree/COG0733
eggNOG	KOG3659	http://eggnogapi.embl.de/nog_data/html/tree/KOG3659
epestfind	swissprot:S6A18_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S6A18_HUMAN
garnier	swissprot:S6A18_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S6A18_HUMAN
helixturnhelix	swissprot:S6A18_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S6A18_HUMAN
hmoment	swissprot:S6A18_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S6A18_HUMAN
iep	swissprot:S6A18_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S6A18_HUMAN
inforesidue	swissprot:S6A18_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S6A18_HUMAN
neXtProt	NX_Q96N87	http://www.nextprot.org/db/entry/NX_Q96N87
octanol	swissprot:S6A18_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S6A18_HUMAN
pepcoil	swissprot:S6A18_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S6A18_HUMAN
pepdigest	swissprot:S6A18_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S6A18_HUMAN
pepinfo	swissprot:S6A18_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S6A18_HUMAN
pepnet	swissprot:S6A18_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S6A18_HUMAN
pepstats	swissprot:S6A18_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S6A18_HUMAN
pepwheel	swissprot:S6A18_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S6A18_HUMAN
pepwindow	swissprot:S6A18_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S6A18_HUMAN
sigcleave	swissprot:S6A18_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S6A18_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SCN3A_HUMAN	Event=Alternative splicing; Named isoforms=4; Comment=Exons 6A and 6N only differ by a single residue.; Name=1; Synonyms=6A-12+12b; IsoId=Q9NY46-1; Sequence=Displayed; Name=2; Synonyms=6A-12; IsoId=Q9NY46-2; Sequence=VSP_001034; Name=3; Synonyms=6N-12+12b; IsoId=Q9NY46-3; Sequence=VSP_001033; Name=4; Synonyms=6N-12; IsoId=Q9NY46-4; Sequence=VSP_001033, VSP_001034; 
# AltName	SCN3A_HUMAN	Sodium channel protein brain III subunit alpha
# AltName	SCN3A_HUMAN	Sodium channel protein type III subunit alpha
# AltName	SCN3A_HUMAN	Voltage-gated sodium channel subtype III
# AltName	SCN3A_HUMAN	Voltage-gated sodium channel subunit alpha Nav1.3
# BioGrid	112233	6
# CCDS	CCDS33312	-. [Q9NY46-3]
# CCDS	CCDS46440	-. [Q9NY46-2]
# ChiTaRS	SCN3A	human
# DOMAIN	SCN3A_HUMAN	The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position. 
# DrugBank	DB00313	Valproic Acid
# DrugBank	DB00909	Zonisamide
# DrugBank	DB06218	Lacosamide
# Ensembl	ENST00000283254	ENSP00000283254; ENSG00000153253. [Q9NY46-3]
# Ensembl	ENST00000360093	ENSP00000353206; ENSG00000153253. [Q9NY46-1]
# Ensembl	ENST00000409101	ENSP00000386726; ENSG00000153253. [Q9NY46-2]
# ExpressionAtlas	Q9NY46	baseline and differential
# FUNCTION	SCN3A_HUMAN	Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. 
# GO_component	GO:0001518	voltage-gated sodium channel complex; IEA:InterPro.
# GO_component	GO:0005737	cytoplasm; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_function	GO:0005248	voltage-gated sodium channel activity; NAS:UniProtKB.
# GO_process	GO:0006814	sodium ion transport; NAS:UniProtKB.
# GO_process	GO:0019228	neuronal action potential; IBA:GO_Central.
# GO_process	GO:0086010	membrane depolarization during action potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.20.120.350	-; 4.
# Genevisible	Q9NY46	HS
# HGNC	HGNC:10590	SCN3A
# IntAct	Q9NY46	2
# InterPro	IPR000048	IQ_motif_EF-hand-BS
# InterPro	IPR001696	Na_channel_asu
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR010526	Na_trans_assoc
# InterPro	IPR024583	Na_trans_cytopl
# InterPro	IPR027359	Channel_four-helix_dom
# KEGG_Brite	ko04040	Ion channels
# MIM	182391	gene
# Organism	SCN3A_HUMAN	Homo sapiens (Human)
# PIR	A54937	A54937
# PRINTS	PR00170	NACHANNEL
# PROSITE	PS50096	IQ
# PTM	SCN3A_HUMAN	May be ubiquitinated by NEDD4L; which would promote its endocytosis. 
# PTM	SCN3A_HUMAN	Phosphorylation at Ser-1501 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents. {ECO 0000250}. 
# Pfam	PF00520	Ion_trans; 4
# Pfam	PF06512	Na_trans_assoc
# Pfam	PF11933	Na_trans_cytopl
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-445095	Interaction between L1 and Ankyrins
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# RecName	SCN3A_HUMAN	Sodium channel protein type 3 subunit alpha
# RefSeq	NP_001075145	NM_001081676.1. [Q9NY46-4]
# RefSeq	NP_001075146	NM_001081677.1. [Q9NY46-2]
# RefSeq	NP_008853	NM_006922.3. [Q9NY46-3]
# RefSeq	XP_011509912	XM_011511610.2. [Q9NY46-3]
# RefSeq	XP_016860149	XM_017004660.1. [Q9NY46-1]
# SIMILARITY	Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.3/SCN3A subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 IQ domain. {ECO:0000255|PROSITE- ProRule	PRU00116}.
# SUBCELLULAR LOCATION	SCN3A_HUMAN	Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUBUNIT	The sodium channel consists of a large polypeptide and 2- 3 smaller ones. This sequence represents a large polypeptide. Interacts with NEDD4L. {ECO:0000269|PubMed	15548568}. 
# UCSC	uc002ucx	human. [Q9NY46-1]
# eggNOG	ENOG410XNP6	LUCA
# eggNOG	KOG2301	Eukaryota
BLAST	swissprot:SCN3A_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SCN3A_HUMAN
BioCyc	ZFISH:ENSG00000153253-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000153253-MONOMER
COXPRESdb	6328	http://coxpresdb.jp/data/gene/6328.shtml
CleanEx	HS_SCN3A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SCN3A
DOI	10.1007/BF02737087	http://dx.doi.org/10.1007/BF02737087
DOI	10.1016/S0378-1119(00)00594-1	http://dx.doi.org/10.1016/S0378-1119(00)00594-1
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/sj.mp.4001241	http://dx.doi.org/10.1038/sj.mp.4001241
DOI	10.1073/pnas.91.8.2975	http://dx.doi.org/10.1073/pnas.91.8.2975
DOI	10.1093/dnares/7.1.65	http://dx.doi.org/10.1093/dnares/7.1.65
DOI	10.1136/jmedgenet-2015-103179	http://dx.doi.org/10.1136/jmedgenet-2015-103179
DOI	10.1152/ajpcell.00460.2004	http://dx.doi.org/10.1152/ajpcell.00460.2004
DrugBank	DB00313	http://www.drugbank.ca/drugs/DB00313
DrugBank	DB00909	http://www.drugbank.ca/drugs/DB00909
DrugBank	DB06218	http://www.drugbank.ca/drugs/DB06218
EMBL	AB037777	http://www.ebi.ac.uk/ena/data/view/AB037777
EMBL	AC013463	http://www.ebi.ac.uk/ena/data/view/AC013463
EMBL	AF035685	http://www.ebi.ac.uk/ena/data/view/AF035685
EMBL	AF035686	http://www.ebi.ac.uk/ena/data/view/AF035686
EMBL	AF225987	http://www.ebi.ac.uk/ena/data/view/AF225987
EMBL	AF239921	http://www.ebi.ac.uk/ena/data/view/AF239921
EMBL	AF330118	http://www.ebi.ac.uk/ena/data/view/AF330118
EMBL	AF330118	http://www.ebi.ac.uk/ena/data/view/AF330118
EMBL	AF330119	http://www.ebi.ac.uk/ena/data/view/AF330119
EMBL	AF330119	http://www.ebi.ac.uk/ena/data/view/AF330119
EMBL	AF330120	http://www.ebi.ac.uk/ena/data/view/AF330120
EMBL	AF330120	http://www.ebi.ac.uk/ena/data/view/AF330120
EMBL	AF330121	http://www.ebi.ac.uk/ena/data/view/AF330121
EMBL	AF330121	http://www.ebi.ac.uk/ena/data/view/AF330121
EMBL	AF330122	http://www.ebi.ac.uk/ena/data/view/AF330122
EMBL	AF330122	http://www.ebi.ac.uk/ena/data/view/AF330122
EMBL	AF330123	http://www.ebi.ac.uk/ena/data/view/AF330123
EMBL	AF330123	http://www.ebi.ac.uk/ena/data/view/AF330123
EMBL	AF330124	http://www.ebi.ac.uk/ena/data/view/AF330124
EMBL	AF330124	http://www.ebi.ac.uk/ena/data/view/AF330124
EMBL	AF330125	http://www.ebi.ac.uk/ena/data/view/AF330125
EMBL	AF330125	http://www.ebi.ac.uk/ena/data/view/AF330125
EMBL	AF330126	http://www.ebi.ac.uk/ena/data/view/AF330126
EMBL	AF330126	http://www.ebi.ac.uk/ena/data/view/AF330126
EMBL	AF330127	http://www.ebi.ac.uk/ena/data/view/AF330127
EMBL	AF330127	http://www.ebi.ac.uk/ena/data/view/AF330127
EMBL	AF330128	http://www.ebi.ac.uk/ena/data/view/AF330128
EMBL	AF330128	http://www.ebi.ac.uk/ena/data/view/AF330128
EMBL	AF330129	http://www.ebi.ac.uk/ena/data/view/AF330129
EMBL	AF330129	http://www.ebi.ac.uk/ena/data/view/AF330129
EMBL	AF330130	http://www.ebi.ac.uk/ena/data/view/AF330130
EMBL	AF330130	http://www.ebi.ac.uk/ena/data/view/AF330130
EMBL	AF330131	http://www.ebi.ac.uk/ena/data/view/AF330131
EMBL	AF330131	http://www.ebi.ac.uk/ena/data/view/AF330131
EMBL	AF330132	http://www.ebi.ac.uk/ena/data/view/AF330132
EMBL	AF330132	http://www.ebi.ac.uk/ena/data/view/AF330132
EMBL	AF330133	http://www.ebi.ac.uk/ena/data/view/AF330133
EMBL	AF330133	http://www.ebi.ac.uk/ena/data/view/AF330133
EMBL	AF330134	http://www.ebi.ac.uk/ena/data/view/AF330134
EMBL	AF330134	http://www.ebi.ac.uk/ena/data/view/AF330134
EMBL	AF330135	http://www.ebi.ac.uk/ena/data/view/AF330135
EMBL	AF330135	http://www.ebi.ac.uk/ena/data/view/AF330135
EMBL	AJ251507	http://www.ebi.ac.uk/ena/data/view/AJ251507
EMBL	S69887	http://www.ebi.ac.uk/ena/data/view/S69887
Ensembl	ENST00000283254	http://www.ensembl.org/id/ENST00000283254
Ensembl	ENST00000360093	http://www.ensembl.org/id/ENST00000360093
Ensembl	ENST00000409101	http://www.ensembl.org/id/ENST00000409101
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0001518	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001518
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_function	GO:0005248	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005248
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0019228	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019228
GO_process	GO:0086010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086010
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	SCN3A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SCN3A
GeneID	6328	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6328
GeneTree	ENSGT00830000128242	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00830000128242
HGNC	HGNC:10590	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10590
HOVERGEN	HBG053100	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053100&db=HOVERGEN
HPA	HPA035396	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035396
InParanoid	Q9NY46	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NY46
IntAct	Q9NY46	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NY46*
InterPro	IPR000048	http://www.ebi.ac.uk/interpro/entry/IPR000048
InterPro	IPR001696	http://www.ebi.ac.uk/interpro/entry/IPR001696
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR010526	http://www.ebi.ac.uk/interpro/entry/IPR010526
InterPro	IPR024583	http://www.ebi.ac.uk/interpro/entry/IPR024583
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
Jabion	6328	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6328
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:6328	http://www.genome.jp/dbget-bin/www_bget?hsa:6328
KEGG_Orthology	KO:K04836	http://www.genome.jp/dbget-bin/www_bget?KO:K04836
MIM	182391	http://www.ncbi.nlm.nih.gov/omim/182391
MINT	MINT-8330038	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8330038
OMA	YFNGTMD	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YFNGTMD
OrthoDB	EOG091G00FK	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00FK
PRINTS	PR00170	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00170
PROSITE	PS50096	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50096
PSORT	swissprot:SCN3A_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SCN3A_HUMAN
PSORT-B	swissprot:SCN3A_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SCN3A_HUMAN
PSORT2	swissprot:SCN3A_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SCN3A_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF06512	http://pfam.xfam.org/family/PF06512
Pfam	PF11933	http://pfam.xfam.org/family/PF11933
PharmGKB	PA35005	http://www.pharmgkb.org/do/serve?objId=PA35005&objCls=Gene
Phobius	swissprot:SCN3A_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SCN3A_HUMAN
PhylomeDB	Q9NY46	http://phylomedb.org/?seqid=Q9NY46
ProteinModelPortal	Q9NY46	http://www.proteinmodelportal.org/query/uniprot/Q9NY46
PubMed	10718198	http://www.ncbi.nlm.nih.gov/pubmed/10718198
PubMed	11245985	http://www.ncbi.nlm.nih.gov/pubmed/11245985
PubMed	12610651	http://www.ncbi.nlm.nih.gov/pubmed/12610651
PubMed	15548568	http://www.ncbi.nlm.nih.gov/pubmed/15548568
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	26566883	http://www.ncbi.nlm.nih.gov/pubmed/26566883
PubMed	8159690	http://www.ncbi.nlm.nih.gov/pubmed/8159690
PubMed	9589372	http://www.ncbi.nlm.nih.gov/pubmed/9589372
Reactome	R-HSA-445095	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-445095
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
RefSeq	NP_001075145	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001075145
RefSeq	NP_001075146	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001075146
RefSeq	NP_008853	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_008853
RefSeq	XP_011509912	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011509912
RefSeq	XP_016860149	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016860149
STRING	9606.ENSP00000283254	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000283254&targetmode=cogs
UCSC	uc002ucx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ucx&org=rat
UniGene	Hs.435274	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.435274
UniProtKB	SCN3A_HUMAN	http://www.uniprot.org/uniprot/SCN3A_HUMAN
UniProtKB-AC	Q9NY46	http://www.uniprot.org/uniprot/Q9NY46
charge	swissprot:SCN3A_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SCN3A_HUMAN
eggNOG	ENOG410XNP6	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNP6
eggNOG	KOG2301	http://eggnogapi.embl.de/nog_data/html/tree/KOG2301
epestfind	swissprot:SCN3A_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SCN3A_HUMAN
garnier	swissprot:SCN3A_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SCN3A_HUMAN
helixturnhelix	swissprot:SCN3A_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SCN3A_HUMAN
hmoment	swissprot:SCN3A_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SCN3A_HUMAN
iep	swissprot:SCN3A_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SCN3A_HUMAN
inforesidue	swissprot:SCN3A_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SCN3A_HUMAN
neXtProt	NX_Q9NY46	http://www.nextprot.org/db/entry/NX_Q9NY46
octanol	swissprot:SCN3A_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SCN3A_HUMAN
pepcoil	swissprot:SCN3A_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SCN3A_HUMAN
pepdigest	swissprot:SCN3A_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SCN3A_HUMAN
pepinfo	swissprot:SCN3A_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SCN3A_HUMAN
pepnet	swissprot:SCN3A_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SCN3A_HUMAN
pepstats	swissprot:SCN3A_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SCN3A_HUMAN
pepwheel	swissprot:SCN3A_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SCN3A_HUMAN
pepwindow	swissprot:SCN3A_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SCN3A_HUMAN
sigcleave	swissprot:SCN3A_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SCN3A_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ODC_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BQT8-1; Sequence=Displayed; Name=2; IsoId=Q9BQT8-2; Sequence=VSP_046690; 
# AltName	ODC_HUMAN	Solute carrier family 25 member 21
# BioGrid	124629	5
# CCDS	CCDS55913	-. [Q9BQT8-2]
# CCDS	CCDS9663	-. [Q9BQT8-1]
# Ensembl	ENST00000331299	ENSP00000329452; ENSG00000183032. [Q9BQT8-1]
# Ensembl	ENST00000555449	ENSP00000451873; ENSG00000183032. [Q9BQT8-2]
# FUNCTION	ODC_HUMAN	Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2- oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate. 
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015139	alpha-ketoglutarate transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0006554	lysine catabolic process; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006520	cellular amino acid metabolic process
# GOslim_process	GO:0009056	catabolic process
# Gene3D	1.50.40.10	-; 1.
# Genevisible	Q9BQT8	HS
# HGNC	HGNC:14411	SLC25A21
# IntAct	Q9BQT8	2
# InterPro	IPR002067	Mit_carrier
# InterPro	IPR018108	Mitochondrial_sb/sol_carrier
# InterPro	IPR023395	Mt_carrier_dom
# KEGG_Brite	ko02001	Solute carrier family
# MIM	607571	gene
# Organism	ODC_HUMAN	Homo sapiens (Human)
# PRINTS	PR00926	MITOCARRIER
# PROSITE	PS50920	SOLCAR; 3
# Pfam	PF00153	Mito_carr; 3
# Proteomes	UP000005640	Chromosome 14
# Reactome	R-HSA-71064	Lysine catabolism
# RecName	ODC_HUMAN	Mitochondrial 2-oxodicarboxylate carrier
# RefSeq	NP_001164641	NM_001171170.1. [Q9BQT8-2]
# RefSeq	NP_085134	NM_030631.3. [Q9BQT8-1]
# SIMILARITY	Belongs to the mitochondrial carrier (TC 2.A.29) family. {ECO	0000305}. 
# SIMILARITY	Contains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule	PRU00282}.
# SUBCELLULAR LOCATION	ODC_HUMAN	Mitochondrion inner membrane; Multi-pass membrane protein. 
# SUPFAM	SSF103506	SSF103506
# TCDB	2.A.29.2	the mitochondrial carrier (mc) family
# TISSUE SPECIFICITY	Ubiquitous. {ECO:0000269|PubMed	11083877}. 
# UCSC	uc001wtz	human. [Q9BQT8-1]
# eggNOG	ENOG410XRZG	LUCA
# eggNOG	KOG0754	Eukaryota
BLAST	swissprot:ODC_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ODC_HUMAN
BioCyc	ZFISH:G66-32919-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32919-MONOMER
COXPRESdb	89874	http://coxpresdb.jp/data/gene/89874.shtml
CleanEx	HS_SLC25A21	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC25A21
DOI	10.1038/nature01348	http://dx.doi.org/10.1038/nature01348
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M009607200	http://dx.doi.org/10.1074/jbc.M009607200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AJ278148	http://www.ebi.ac.uk/ena/data/view/AJ278148
EMBL	AK289575	http://www.ebi.ac.uk/ena/data/view/AK289575
EMBL	AL079303	http://www.ebi.ac.uk/ena/data/view/AL079303
EMBL	AL079304	http://www.ebi.ac.uk/ena/data/view/AL079304
EMBL	AL121775	http://www.ebi.ac.uk/ena/data/view/AL121775
EMBL	AL162464	http://www.ebi.ac.uk/ena/data/view/AL162464
EMBL	BC101521	http://www.ebi.ac.uk/ena/data/view/BC101521
EMBL	BC113365	http://www.ebi.ac.uk/ena/data/view/BC113365
Ensembl	ENST00000331299	http://www.ensembl.org/id/ENST00000331299
Ensembl	ENST00000555449	http://www.ensembl.org/id/ENST00000555449
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015139
GO_process	GO:0006554	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006554
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520
GOslim_process	GO:0009056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056
Gene3D	1.50.40.10	http://www.cathdb.info/version/latest/superfamily/1.50.40.10
GeneCards	SLC25A21	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC25A21
GeneID	89874	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=89874
GeneTree	ENSGT00730000111119	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00730000111119
H-InvDB	HIX0037719	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0037719
HGNC	HGNC:14411	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14411
HOGENOM	HOG000168307	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000168307&db=HOGENOM6
HOVERGEN	HBG105598	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG105598&db=HOVERGEN
HPA	HPA000662	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA000662
InParanoid	Q9BQT8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9BQT8
IntAct	Q9BQT8	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9BQT8*
InterPro	IPR002067	http://www.ebi.ac.uk/interpro/entry/IPR002067
InterPro	IPR018108	http://www.ebi.ac.uk/interpro/entry/IPR018108
InterPro	IPR023395	http://www.ebi.ac.uk/interpro/entry/IPR023395
Jabion	89874	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=89874
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:89874	http://www.genome.jp/dbget-bin/www_bget?hsa:89874
KEGG_Orthology	KO:K15110	http://www.genome.jp/dbget-bin/www_bget?KO:K15110
MIM	607571	http://www.ncbi.nlm.nih.gov/omim/607571
OMA	MATVYKE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MATVYKE
OrthoDB	EOG091G0DEF	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0DEF
PRINTS	PR00926	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00926
PROSITE	PS50920	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50920
PSORT	swissprot:ODC_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ODC_HUMAN
PSORT-B	swissprot:ODC_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ODC_HUMAN
PSORT2	swissprot:ODC_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ODC_HUMAN
Pfam	PF00153	http://pfam.xfam.org/family/PF00153
PharmGKB	PA37880	http://www.pharmgkb.org/do/serve?objId=PA37880&objCls=Gene
Phobius	swissprot:ODC_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ODC_HUMAN
PhylomeDB	Q9BQT8	http://phylomedb.org/?seqid=Q9BQT8
ProteinModelPortal	Q9BQT8	http://www.proteinmodelportal.org/query/uniprot/Q9BQT8
PubMed	11083877	http://www.ncbi.nlm.nih.gov/pubmed/11083877
PubMed	12508121	http://www.ncbi.nlm.nih.gov/pubmed/12508121
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
Reactome	R-HSA-71064	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-71064
RefSeq	NP_001164641	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001164641
RefSeq	NP_085134	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_085134
STRING	9606.ENSP00000329452	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000329452&targetmode=cogs
SUPFAM	SSF103506	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103506
TCDB	2.A.29.2	http://www.tcdb.org/search/result.php?tc=2.A.29.2
UCSC	uc001wtz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001wtz&org=rat
UniGene	Hs.730857	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.730857
UniProtKB	ODC_HUMAN	http://www.uniprot.org/uniprot/ODC_HUMAN
UniProtKB-AC	Q9BQT8	http://www.uniprot.org/uniprot/Q9BQT8
charge	swissprot:ODC_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ODC_HUMAN
eggNOG	ENOG410XRZG	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRZG
eggNOG	KOG0754	http://eggnogapi.embl.de/nog_data/html/tree/KOG0754
epestfind	swissprot:ODC_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ODC_HUMAN
garnier	swissprot:ODC_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ODC_HUMAN
helixturnhelix	swissprot:ODC_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ODC_HUMAN
hmoment	swissprot:ODC_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ODC_HUMAN
iep	swissprot:ODC_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ODC_HUMAN
inforesidue	swissprot:ODC_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ODC_HUMAN
neXtProt	NX_Q9BQT8	http://www.nextprot.org/db/entry/NX_Q9BQT8
octanol	swissprot:ODC_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ODC_HUMAN
pepcoil	swissprot:ODC_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ODC_HUMAN
pepdigest	swissprot:ODC_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ODC_HUMAN
pepinfo	swissprot:ODC_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ODC_HUMAN
pepnet	swissprot:ODC_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ODC_HUMAN
pepstats	swissprot:ODC_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ODC_HUMAN
pepwheel	swissprot:ODC_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ODC_HUMAN
pepwindow	swissprot:ODC_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ODC_HUMAN
sigcleave	swissprot:ODC_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ODC_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5JTJ3-1; Sequence=Displayed; Name=2; IsoId=Q5JTJ3-2; Sequence=VSP_023656; Note=Gene prediction based on EST data.; Name=3; IsoId=Q5JTJ3-3; Sequence=VSP_023655; Note=Gene prediction based on EST data. Initiator Met-1 is removed. Contains a N-acetylalanine at position 2. {ECO:0000244|PubMed	22814378}; 
# BioGrid	132839	2
# CCDS	CCDS31059	-. [Q5JTJ3-1]
# CCDS	CCDS55690	-. [Q5JTJ3-3]
# CDD	cd00926	Cyt_c_Oxidase_VIb
# DISEASE	COA6_HUMAN	Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 4 (CEMCOX4) [MIM 616501]  An infantile disorder with a fatal course in the first weeks of life, characterized by hypertrophic cardiomyopathy, left ventricular non-compaction, lactic acidosis, metabolic hypotonia, and mitochondrial complex IV deficiency. {ECO 0000269|PubMed 24549041, ECO 0000269|PubMed 25339201}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000366612	ENSP00000355571; ENSG00000168275. [Q5JTJ3-3]
# Ensembl	ENST00000366613	ENSP00000355572; ENSG00000168275. [Q5JTJ3-1]
# Ensembl	ENST00000619305	ENSP00000479686; ENSG00000168275. [Q5JTJ3-3]
# ExpressionAtlas	Q5JTJ3	baseline and differential
# FUNCTION	COA6_HUMAN	Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV. {ECO 0000269|PubMed 24549041, ECO 0000269|PubMed 25959673, ECO 0000269|PubMed 26160915}. 
# GO_component	GO:0005739	mitochondrion; ISS:UniProtKB.
# GO_component	GO:0005758	mitochondrial intermembrane space; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IEA:GOC.
# GO_function	GO:0004129	cytochrome-c oxidase activity; IEA:InterPro.
# GO_function	GO:0005507	copper ion binding; IDA:UniProtKB.
# GO_function	GO:0044822	poly(A) RNA binding; IDA:UniProtKB.
# GO_process	GO:0008535	respiratory chain complex IV assembly; IDA:UniProtKB.
# GO_process	GO:0042774	plasma membrane ATP synthesis coupled electron transport; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003723	RNA binding
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# GOslim_process	GO:0006461	protein complex assembly
# Gene3D	1.10.10.140	-; 1.
# Genevisible	Q5JTJ3	HS
# HGNC	HGNC:18025	COA6
# IntAct	Q5JTJ3	3
# InterPro	IPR003213	Cyt_c_oxidase_su6B
# MIM	614772	gene
# MIM	616501	phenotype
# Organism	COA6_HUMAN	Homo sapiens (Human)
# PROSITE	PS51808	CHCH
# Pfam	PF02297	COX6B
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-1268020	Mitochondrial protein import
# RecName	COA6_HUMAN	Cytochrome c oxidase assembly factor 6 homolog
# RefSeq	NP_001013003	NM_001012985.2. [Q5JTJ3-1]
# RefSeq	NP_001288662	NM_001301733.1. [Q5JTJ3-3]
# SEQUENCE CAUTION	Sequence=AAH25793.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH25793.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the cytochrome c oxidase subunit 6B family. {ECO	0000305}. 
# SIMILARITY	Contains 1 CHCH (coiled coil-helix-coiled coil-helix) domain. {ECO:0000255|PROSITE-ProRule	PRU01150}. 
# SUBCELLULAR LOCATION	COA6_HUMAN	Mitochondrion intermembrane space {ECO 0000269|PubMed 25339201, ECO 0000269|PubMed 25959673}. 
# SUBUNIT	COA6_HUMAN	Interacts with COA1 (PubMed 22356826). Interacts with MT- CO2 (PubMed 25959673). Interacts with SCO2 (PubMed 25959673). Interacts with SCO1 (PubMed 26160915). {ECO 0000269|PubMed 22356826, ECO 0000269|PubMed 25959673, ECO 0000269|PubMed 26160915}. 
# SUPFAM	SSF47694	SSF47694
# UCSC	uc001hwc	human. [Q5JTJ3-1]
# WEB RESOURCE	COA6_HUMAN	Name=LOVD-Leiden Open Variation Database; Note=cytochrome c oxidase assembly factor 6 homolog (S. cerevisiae) (COA6); URL="http //databases.lovd.nl/shared/genes/COA6";
# eggNOG	ENOG41121WM	LUCA
# eggNOG	KOG3057	Eukaryota
BLAST	swissprot:COA6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:COA6_HUMAN
COXPRESdb	388753	http://coxpresdb.jp/data/gene/388753.shtml
CleanEx	HS_C1orf31	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_C1orf31
DOI	10.1002/humu.22715	http://dx.doi.org/10.1002/humu.22715
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.cmet.2015.04.012	http://dx.doi.org/10.1016/j.cmet.2015.04.012
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1093/hmg/ddu069	http://dx.doi.org/10.1093/hmg/ddu069
DOI	10.1093/hmg/ddv265	http://dx.doi.org/10.1093/hmg/ddv265
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1186/gb-2012-13-2-r12	http://dx.doi.org/10.1186/gb-2012-13-2-r12
EMBL	AL355472	http://www.ebi.ac.uk/ena/data/view/AL355472
EMBL	AL355472	http://www.ebi.ac.uk/ena/data/view/AL355472
EMBL	AL355472	http://www.ebi.ac.uk/ena/data/view/AL355472
EMBL	BC025793	http://www.ebi.ac.uk/ena/data/view/BC025793
EMBL	BC116455	http://www.ebi.ac.uk/ena/data/view/BC116455
Ensembl	ENST00000366612	http://www.ensembl.org/id/ENST00000366612
Ensembl	ENST00000366613	http://www.ensembl.org/id/ENST00000366613
Ensembl	ENST00000619305	http://www.ensembl.org/id/ENST00000619305
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005758	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005758
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_function	GO:0004129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004129
GO_function	GO:0005507	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005507
GO_function	GO:0044822	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044822
GO_process	GO:0008535	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008535
GO_process	GO:0042774	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042774
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003723	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
Gene3D	1.10.10.140	http://www.cathdb.info/version/latest/superfamily/1.10.10.140
GeneCards	COA6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=COA6
GeneID	388753	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=388753
GeneTree	ENSGT00390000004094	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000004094
HGNC	HGNC:18025	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18025
HOGENOM	HOG000196422	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000196422&db=HOGENOM6
HOVERGEN	HBG056284	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG056284&db=HOVERGEN
HPA	HPA028588	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA028588
InParanoid	Q5JTJ3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q5JTJ3
IntAct	Q5JTJ3	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q5JTJ3*
InterPro	IPR003213	http://www.ebi.ac.uk/interpro/entry/IPR003213
Jabion	388753	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=388753
KEGG_Gene	hsa:388753	http://www.genome.jp/dbget-bin/www_bget?hsa:388753
MIM	614772	http://www.ncbi.nlm.nih.gov/omim/614772
MIM	616501	http://www.ncbi.nlm.nih.gov/omim/616501
OMA	LLGDCGP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LLGDCGP
PROSITE	PS51808	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51808
PSORT	swissprot:COA6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:COA6_HUMAN
PSORT-B	swissprot:COA6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:COA6_HUMAN
PSORT2	swissprot:COA6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:COA6_HUMAN
Pfam	PF02297	http://pfam.xfam.org/family/PF02297
PharmGKB	PA25617	http://www.pharmgkb.org/do/serve?objId=PA25617&objCls=Gene
Phobius	swissprot:COA6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:COA6_HUMAN
PhylomeDB	Q5JTJ3	http://phylomedb.org/?seqid=Q5JTJ3
ProteinModelPortal	Q5JTJ3	http://www.proteinmodelportal.org/query/uniprot/Q5JTJ3
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22356826	http://www.ncbi.nlm.nih.gov/pubmed/22356826
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	24549041	http://www.ncbi.nlm.nih.gov/pubmed/24549041
PubMed	25339201	http://www.ncbi.nlm.nih.gov/pubmed/25339201
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	25959673	http://www.ncbi.nlm.nih.gov/pubmed/25959673
PubMed	26160915	http://www.ncbi.nlm.nih.gov/pubmed/26160915
Reactome	R-HSA-1268020	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1268020
RefSeq	NP_001013003	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001013003
RefSeq	NP_001288662	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001288662
STRING	9606.ENSP00000355572	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000355572&targetmode=cogs
SUPFAM	SSF47694	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47694
UCSC	uc001hwc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001hwc&org=rat
UniGene	Hs.23198	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.23198
UniProtKB	COA6_HUMAN	http://www.uniprot.org/uniprot/COA6_HUMAN
UniProtKB-AC	Q5JTJ3	http://www.uniprot.org/uniprot/Q5JTJ3
charge	swissprot:COA6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:COA6_HUMAN
eggNOG	ENOG41121WM	http://eggnogapi.embl.de/nog_data/html/tree/ENOG41121WM
eggNOG	KOG3057	http://eggnogapi.embl.de/nog_data/html/tree/KOG3057
epestfind	swissprot:COA6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:COA6_HUMAN
garnier	swissprot:COA6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:COA6_HUMAN
helixturnhelix	swissprot:COA6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:COA6_HUMAN
hmoment	swissprot:COA6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:COA6_HUMAN
iep	swissprot:COA6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:COA6_HUMAN
inforesidue	swissprot:COA6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:COA6_HUMAN
neXtProt	NX_Q5JTJ3	http://www.nextprot.org/db/entry/NX_Q5JTJ3
octanol	swissprot:COA6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:COA6_HUMAN
pepcoil	swissprot:COA6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:COA6_HUMAN
pepdigest	swissprot:COA6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:COA6_HUMAN
pepinfo	swissprot:COA6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:COA6_HUMAN
pepnet	swissprot:COA6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:COA6_HUMAN
pepstats	swissprot:COA6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:COA6_HUMAN
pepwheel	swissprot:COA6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:COA6_HUMAN
pepwindow	swissprot:COA6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:COA6_HUMAN
sigcleave	swissprot:COA6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:COA6_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCND3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=KCND3L, Long; IsoId=Q9UK17-1; Sequence=Displayed; Name=2; Synonyms=KCND3S, Short; IsoId=Q9UK17-2; Sequence=VSP_008826; 
# AltName	KCND3_HUMAN	Voltage-gated potassium channel subunit Kv4.3
# BioGrid	109954	35
# CCDS	CCDS843	-. [Q9UK17-1]
# CCDS	CCDS844	-. [Q9UK17-2]
# DISEASE	KCND3_HUMAN	Brugada syndrome 9 (BRGDA9) [MIM 616399]  A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset. {ECO 0000269|PubMed 21349352, ECO 0000269|PubMed 22457051}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	KCND3_HUMAN	Spinocerebellar ataxia 19 (SCA19) [MIM 607346]  A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA19 is a relatively mild, cerebellar ataxic syndrome with cognitive impairment, pyramidal tract involvement, tremor and peripheral neuropathy, and mild atrophy of the cerebellar hemispheres and vermis. {ECO 0000269|PubMed 23280837, ECO 0000269|PubMed 23280838}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	KCND3_HUMAN	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. 
# DrugBank	DB00280	Disopyramide
# DrugBank	DB00321	Amitriptyline
# DrugBank	DB00458	Imipramine
# DrugBank	DB06637	Dalfampridine
# Ensembl	ENST00000302127	ENSP00000306923; ENSG00000171385. [Q9UK17-2]
# Ensembl	ENST00000315987	ENSP00000319591; ENSG00000171385. [Q9UK17-1]
# Ensembl	ENST00000369697	ENSP00000358711; ENSG00000171385. [Q9UK17-2]
# ExpressionAtlas	Q9UK17	baseline and differential
# FUNCTION	KCND3_HUMAN	Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. {ECO 0000269|PubMed 10200233, ECO 0000269|PubMed 9843794}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IDA:BHF-UCL.
# GO_component	GO:0030425	dendrite; IEA:UniProtKB-SubCell.
# GO_component	GO:0042383	sarcolemma; IEA:UniProtKB-SubCell.
# GO_function	GO:0005250	A-type (transient outward) potassium channel activity; TAS:ProtInc.
# GO_function	GO:0044325	ion channel binding; IPI:BHF-UCL.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0051260	protein homooligomerization; IEA:InterPro.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:0071435	potassium ion export; IDA:BHF-UCL.
# GO_process	GO:0086009	membrane repolarization; IDA:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.350	-; 1.
# Genevisible	Q9UK17	HS
# HGNC	HGNC:6239	KCND3
# INTERACTION	KCND3_HUMAN	Q9NZI2 KCNIP1; NbExp=3; IntAct=EBI-9825212, EBI-2120635; 
# InterPro	IPR000210	BTB/POZ_dom
# InterPro	IPR003131	T1-type_BTB
# InterPro	IPR003968	K_chnl_volt-dep_Kv
# InterPro	IPR003975	K_chnl_volt-dep_Kv4
# InterPro	IPR004056	K_chnl_volt-dep_Kv4.3
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR011333	SKP1/BTB/POZ
# InterPro	IPR021645	Shal-type_N
# InterPro	IPR024587	K_chnl_volt-dep_Kv4_C
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko04040	Ion channels
# MIM	605411	gene
# MIM	607346	phenotype
# MIM	616399	phenotype
# Organism	KCND3_HUMAN	Homo sapiens (Human)
# Orphanet	130	Brugada syndrome
# Orphanet	98772	Spinocerebellar ataxia type 19/22
# PANTHER	PTHR11537	PTHR11537; 2
# PDB	1S1G	X-ray; 2.60 A; A/B=29-143
# PDB	2NZ0	X-ray; 3.20 A; B/D=6-145
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01491	KVCHANNEL
# PRINTS	PR01497	SHALCHANNEL
# PRINTS	PR01518	KV43CHANNEL
# PTM	KCND3_HUMAN	Regulated through phosphorylation at Ser-569 by CaMK2D. {ECO 0000250}. 
# Pfam	PF00520	Ion_trans
# Pfam	PF02214	BTB_2
# Pfam	PF11601	Shal-type
# Pfam	PF11879	DUF3399
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# Reactome	R-HSA-5576894	Phase 1 - inactivation of fast Na+ channels
# RecName	KCND3_HUMAN	Potassium voltage-gated channel subfamily D member 3
# RefSeq	NP_004971	NM_004980.4. [Q9UK17-1]
# RefSeq	NP_751948	NM_172198.2. [Q9UK17-2]
# RefSeq	XP_005270908	XM_005270851.4. [Q9UK17-1]
# RefSeq	XP_006710692	XM_006710629.3. [Q9UK17-1]
# RefSeq	XP_006710693	XM_006710630.3. [Q9UK17-2]
# RefSeq	XP_016856733	XM_017001244.1. [Q9UK17-1]
# SIMILARITY	Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily. {ECO	0000305}. 
# SMART	SM00225	BTB
# SUBCELLULAR LOCATION	KCND3_HUMAN	Cell membrane {ECO 0000250|UniProtKB Q62897}; Multi-pass membrane protein {ECO 0000255}. Cell membrane, sarcolemma {ECO 0000250|UniProtKB Q62897}; Multi-pass membrane protein {ECO 0000255}. Cell projection, dendrite {ECO 0000250|UniProtKB Q62897}. Note=Interaction with palmitoylated KCNIP2 and KCNIP3 enhances cell surface expression. {ECO 0000250|UniProtKB Q62897}. 
# SUBUNIT	KCND3_HUMAN	Homotetramer or heterotetramer with KCND1 and/or KCND2. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4 (By similarity). Interacts with KCNE1, KCNE2, SCN1B and KCNAB1 and DLG1. {ECO 0000250, ECO 0000269|PubMed 12297301, ECO 0000269|PubMed 14980207, ECO 0000269|PubMed 17187064, ECO 0000269|PubMed 19213956}. 
# SUPFAM	SSF54695	SSF54695
# TCDB	1.A.1.2.19	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	KCND3_HUMAN	Highly expressed in heart and brain, in particular in cortex, cerebellum, amygdala and caudate nucleus. Detected at lower levels in liver, skeletal muscle, kidney and pancreas. Isoform 1 predominates in most tissues. Isoform 1 and isoform 2 are detected at similar levels in brain, skeletal muscle and pancreas. {ECO 0000269|PubMed 10200233, ECO 0000269|PubMed 10729221, ECO 0000269|PubMed 9843794}. 
# UCSC	uc001ebu	human. [Q9UK17-1]
# WEB RESOURCE	KCND3_HUMAN	Name=Potassium voltage-gated channel, Shal-related subfamily, member 3 (KCND3); Note=Leiden Open Variation Database (LOVD); URL="http //www.lovd.nl/KCND3";
# eggNOG	COG1226	LUCA
# eggNOG	KOG4390	Eukaryota
BLAST	swissprot:KCND3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCND3_HUMAN
COXPRESdb	3752	http://coxpresdb.jp/data/gene/3752.shtml
CleanEx	HS_KCND3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCND3
DOI	10.1002/ana.23700	http://dx.doi.org/10.1002/ana.23700
DOI	10.1002/ana.23701	http://dx.doi.org/10.1002/ana.23701
DOI	10.1002/humu.22058	http://dx.doi.org/10.1002/humu.22058
DOI	10.1006/geno.2000.6117	http://dx.doi.org/10.1006/geno.2000.6117
DOI	10.1016/S0014-5793(02)03296-9	http://dx.doi.org/10.1016/S0014-5793(02)03296-9
DOI	10.1016/S0896-6273(04)00049-2	http://dx.doi.org/10.1016/S0896-6273(04)00049-2
DOI	10.1016/j.hrthm.2011.02.021	http://dx.doi.org/10.1016/j.hrthm.2011.02.021
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/nn1822	http://dx.doi.org/10.1038/nn1822
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1161/CIRCRESAHA.108.191007	http://dx.doi.org/10.1161/CIRCRESAHA.108.191007
DrugBank	DB00280	http://www.drugbank.ca/drugs/DB00280
DrugBank	DB00321	http://www.drugbank.ca/drugs/DB00321
DrugBank	DB00458	http://www.drugbank.ca/drugs/DB00458
DrugBank	DB06637	http://www.drugbank.ca/drugs/DB06637
EMBL	AF048712	http://www.ebi.ac.uk/ena/data/view/AF048712
EMBL	AF048713	http://www.ebi.ac.uk/ena/data/view/AF048713
EMBL	AF120491	http://www.ebi.ac.uk/ena/data/view/AF120491
EMBL	AF166009	http://www.ebi.ac.uk/ena/data/view/AF166009
EMBL	AF166009	http://www.ebi.ac.uk/ena/data/view/AF166009
EMBL	AF166010	http://www.ebi.ac.uk/ena/data/view/AF166010
EMBL	AF166010	http://www.ebi.ac.uk/ena/data/view/AF166010
EMBL	AF166011	http://www.ebi.ac.uk/ena/data/view/AF166011
EMBL	AF166011	http://www.ebi.ac.uk/ena/data/view/AF166011
EMBL	AF187963	http://www.ebi.ac.uk/ena/data/view/AF187963
EMBL	AF187964	http://www.ebi.ac.uk/ena/data/view/AF187964
EMBL	AF205856	http://www.ebi.ac.uk/ena/data/view/AF205856
EMBL	AF205857	http://www.ebi.ac.uk/ena/data/view/AF205857
EMBL	AL049557	http://www.ebi.ac.uk/ena/data/view/AL049557
EMBL	AL049557	http://www.ebi.ac.uk/ena/data/view/AL049557
EMBL	AL049557	http://www.ebi.ac.uk/ena/data/view/AL049557
EMBL	AL450997	http://www.ebi.ac.uk/ena/data/view/AL450997
EMBL	AL450997	http://www.ebi.ac.uk/ena/data/view/AL450997
EMBL	AL450997	http://www.ebi.ac.uk/ena/data/view/AL450997
EMBL	AL512665	http://www.ebi.ac.uk/ena/data/view/AL512665
EMBL	AL512665	http://www.ebi.ac.uk/ena/data/view/AL512665
EMBL	AL512665	http://www.ebi.ac.uk/ena/data/view/AL512665
EMBL	BC113475	http://www.ebi.ac.uk/ena/data/view/BC113475
EMBL	BC113477	http://www.ebi.ac.uk/ena/data/view/BC113477
EMBL	CH471122	http://www.ebi.ac.uk/ena/data/view/CH471122
Ensembl	ENST00000302127	http://www.ensembl.org/id/ENST00000302127
Ensembl	ENST00000315987	http://www.ensembl.org/id/ENST00000315987
Ensembl	ENST00000369697	http://www.ensembl.org/id/ENST00000369697
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0042383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042383
GO_function	GO:0005250	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005250
GO_function	GO:0044325	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044325
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:0071435	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071435
GO_process	GO:0086009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086009
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	KCND3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCND3
GeneID	3752	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3752
GeneTree	ENSGT00760000118846	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118846
HGNC	HGNC:6239	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6239
HOVERGEN	HBG106687	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG106687&db=HOVERGEN
HPA	HPA029452	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA029452
InParanoid	Q9UK17	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UK17
IntAct	Q9UK17	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9UK17*
InterPro	IPR000210	http://www.ebi.ac.uk/interpro/entry/IPR000210
InterPro	IPR003131	http://www.ebi.ac.uk/interpro/entry/IPR003131
InterPro	IPR003968	http://www.ebi.ac.uk/interpro/entry/IPR003968
InterPro	IPR003975	http://www.ebi.ac.uk/interpro/entry/IPR003975
InterPro	IPR004056	http://www.ebi.ac.uk/interpro/entry/IPR004056
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR011333	http://www.ebi.ac.uk/interpro/entry/IPR011333
InterPro	IPR021645	http://www.ebi.ac.uk/interpro/entry/IPR021645
InterPro	IPR024587	http://www.ebi.ac.uk/interpro/entry/IPR024587
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	3752	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3752
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3752	http://www.genome.jp/dbget-bin/www_bget?hsa:3752
KEGG_Orthology	KO:K04893	http://www.genome.jp/dbget-bin/www_bget?KO:K04893
MIM	605411	http://www.ncbi.nlm.nih.gov/omim/605411
MIM	607346	http://www.ncbi.nlm.nih.gov/omim/607346
MIM	616399	http://www.ncbi.nlm.nih.gov/omim/616399
OMA	PNQKEVP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PNQKEVP
Orphanet	130	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=130
Orphanet	98772	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98772
OrthoDB	EOG091G18X0	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G18X0
PANTHER	PTHR11537	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537
PDB	1S1G	http://www.ebi.ac.uk/pdbe-srv/view/entry/1S1G
PDB	2NZ0	http://www.ebi.ac.uk/pdbe-srv/view/entry/2NZ0
PDBsum	1S1G	http://www.ebi.ac.uk/pdbsum/1S1G
PDBsum	2NZ0	http://www.ebi.ac.uk/pdbsum/2NZ0
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01491	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01491
PRINTS	PR01497	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01497
PRINTS	PR01518	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01518
PSORT	swissprot:KCND3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCND3_HUMAN
PSORT-B	swissprot:KCND3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCND3_HUMAN
PSORT2	swissprot:KCND3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCND3_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF02214	http://pfam.xfam.org/family/PF02214
Pfam	PF11601	http://pfam.xfam.org/family/PF11601
Pfam	PF11879	http://pfam.xfam.org/family/PF11879
PharmGKB	PA210	http://www.pharmgkb.org/do/serve?objId=PA210&objCls=Gene
Phobius	swissprot:KCND3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCND3_HUMAN
PhylomeDB	Q9UK17	http://phylomedb.org/?seqid=Q9UK17
ProteinModelPortal	Q9UK17	http://www.proteinmodelportal.org/query/uniprot/Q9UK17
PubMed	10200233	http://www.ncbi.nlm.nih.gov/pubmed/10200233
PubMed	10729221	http://www.ncbi.nlm.nih.gov/pubmed/10729221
PubMed	12297301	http://www.ncbi.nlm.nih.gov/pubmed/12297301
PubMed	14980207	http://www.ncbi.nlm.nih.gov/pubmed/14980207
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	17187064	http://www.ncbi.nlm.nih.gov/pubmed/17187064
PubMed	19213956	http://www.ncbi.nlm.nih.gov/pubmed/19213956
PubMed	21349352	http://www.ncbi.nlm.nih.gov/pubmed/21349352
PubMed	22457051	http://www.ncbi.nlm.nih.gov/pubmed/22457051
PubMed	23280837	http://www.ncbi.nlm.nih.gov/pubmed/23280837
PubMed	23280838	http://www.ncbi.nlm.nih.gov/pubmed/23280838
PubMed	9843794	http://www.ncbi.nlm.nih.gov/pubmed/9843794
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
Reactome	R-HSA-5576894	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576894
RefSeq	NP_004971	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004971
RefSeq	NP_751948	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_751948
RefSeq	XP_005270908	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005270908
RefSeq	XP_006710692	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006710692
RefSeq	XP_006710693	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006710693
RefSeq	XP_016856733	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016856733
SMART	SM00225	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225
SMR	Q9UK17	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9UK17
STRING	9606.ENSP00000319591	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000319591&targetmode=cogs
SUPFAM	SSF54695	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54695
TCDB	1.A.1.2.19	http://www.tcdb.org/search/result.php?tc=1.A.1.2.19
UCSC	uc001ebu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001ebu&org=rat
UniGene	Hs.666367	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.666367
UniGene	Hs.730579	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.730579
UniProtKB	KCND3_HUMAN	http://www.uniprot.org/uniprot/KCND3_HUMAN
UniProtKB-AC	Q9UK17	http://www.uniprot.org/uniprot/Q9UK17
charge	swissprot:KCND3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCND3_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG4390	http://eggnogapi.embl.de/nog_data/html/tree/KOG4390
epestfind	swissprot:KCND3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCND3_HUMAN
garnier	swissprot:KCND3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCND3_HUMAN
helixturnhelix	swissprot:KCND3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCND3_HUMAN
hmoment	swissprot:KCND3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCND3_HUMAN
iep	swissprot:KCND3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCND3_HUMAN
inforesidue	swissprot:KCND3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCND3_HUMAN
neXtProt	NX_Q9UK17	http://www.nextprot.org/db/entry/NX_Q9UK17
octanol	swissprot:KCND3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCND3_HUMAN
pepcoil	swissprot:KCND3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCND3_HUMAN
pepdigest	swissprot:KCND3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCND3_HUMAN
pepinfo	swissprot:KCND3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCND3_HUMAN
pepnet	swissprot:KCND3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCND3_HUMAN
pepstats	swissprot:KCND3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCND3_HUMAN
pepwheel	swissprot:KCND3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCND3_HUMAN
pepwindow	swissprot:KCND3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCND3_HUMAN
sigcleave	swissprot:KCND3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCND3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNQ3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O43525-1; Sequence=Displayed; Name=2; IsoId=O43525-2; Sequence=VSP_044906, VSP_044907; Note=No experimental confirmation available.; 
# AltName	KCNQ3_HUMAN	KQT-like 3
# AltName	KCNQ3_HUMAN	Potassium channel subunit alpha KvLQT3
# AltName	KCNQ3_HUMAN	Voltage-gated potassium channel subunit Kv7.3
# BioGrid	109987	2
# CCDS	CCDS34943	-. [O43525-1]
# CCDS	CCDS56554	-. [O43525-2]
# ChiTaRS	KCNQ3	human
# DISEASE	KCNQ3_HUMAN	Note=Defects in KCNQ3 may be involved in epileptic disorders. These are characterized by paroxysmal transient disturbances of the electrical activity of the brain that may be manifested as episodic impairment or loss of consciousness, abnormal motor phenomena, psychic or sensory disturbances, or perturbation of the autonomic nervous system. {ECO 0000269|PubMed 22612257}. 
# DISEASE	KCNQ3_HUMAN	Seizures, benign familial neonatal 2 (BFNS2) [MIM 121201]  A disorder characterized by clusters of seizures occurring in the first days of life. Most patients have spontaneous remission by 12 months of age and show normal psychomotor development. The disorder is distinguished from benign familial infantile seizures by an earlier age at onset. {ECO 0000269|PubMed 10852552, ECO 0000269|PubMed 14534157, ECO 0000269|PubMed 9425900}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	KCNQ3_HUMAN	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. {ECO 0000250}. 
# DrugBank	DB00321	Amitriptyline
# DrugBank	DB00586	Diclofenac
# DrugBank	DB00939	Meclofenamic acid
# DrugBank	DB04953	Ezogabine
# Ensembl	ENST00000388996	ENSP00000373648; ENSG00000184156. [O43525-1]
# Ensembl	ENST00000521134	ENSP00000429799; ENSG00000184156. [O43525-2]
# ExpressionAtlas	O43525	baseline and differential
# FUNCTION	KCNQ3_HUMAN	Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. 
# GO_component	GO:0005886	plasma membrane; ISS:BHF-UCL.
# GO_component	GO:0008076	voltage-gated potassium channel complex; TAS:ProtInc.
# GO_component	GO:0009986	cell surface; IEA:Ensembl.
# GO_component	GO:0033268	node of Ranvier; ISS:BHF-UCL.
# GO_component	GO:0043194	axon initial segment; ISS:BHF-UCL.
# GO_function	GO:0005249	voltage-gated potassium channel activity; TAS:ProtInc.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; IBA:GO_Central.
# GO_function	GO:0005267	potassium channel activity; TAS:ProtInc.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:ProtInc.
# GO_process	GO:0060081	membrane hyperpolarization; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# Genevisible	O43525	HS
# HGNC	HGNC:6297	KCNQ3
# InterPro	IPR003937	K_chnl_volt-dep_KCNQ
# InterPro	IPR003948	K_chnl_volt-dep_KCNQ3
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR013821	K_chnl_volt-dep_KCNQ_C
# InterPro	IPR020969	Ankyrin-G_BS
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00806	[Nervous system disease] Benign familial infantile epilepsy (BFIE)
# KEGG_Pathway	ko04725	Cholinergic synapse
# MIM	121201	phenotype
# MIM	602232	gene
# MISCELLANEOUS	Mutagenesis experiments were carried out in Xenopus oocytes by coexpression of either KCNQ3(mut) and KCNQ2 at the ratio of 1:1, or of KCNQ3(mut), KCNQ3(wt) and KCNQ2 at the ratio of 1	1:2, to mimic the situation in a heterozygous patient with BFNC2 disease. 
# Organism	KCNQ3_HUMAN	Homo sapiens (Human)
# Orphanet	1949	Benign familial neonatal seizures
# Orphanet	306	Benign familial infantile epilepsy
# Orphanet	307	Juvenile myoclonic epilepsy
# PANTHER	PTHR11537	PTHR11537; 3
# PANTHER	PTHR11537:SF5	PTHR11537:SF5; 3
# PDB	5J03	X-ray; 2.00 A; A=354-409
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01459	KCNQCHANNEL
# PRINTS	PR01462	KCNQ3CHANNEL
# Pfam	PF00520	Ion_trans
# Pfam	PF03520	KCNQ_channel
# Pfam	PF11956	KCNQC3-Ank-G_bd
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# Reactome	R-HSA-445095	Interaction between L1 and Ankyrins
# RecName	KCNQ3_HUMAN	Potassium voltage-gated channel subfamily KQT member 3
# RefSeq	NP_001191753	NM_001204824.1. [O43525-2]
# RefSeq	NP_004510	NM_004519.3. [O43525-1]
# SEQUENCE CAUTION	Sequence=AAI28577.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI28577.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.3/KCNQ3 sub-subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	KCNQ3_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	KCNQ3_HUMAN	Heteromultimer with KCNQ2 or KCNQ5. May associate with KCNE2. 
# TCDB	1.A.1.15	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	KCNQ3_HUMAN	Predominantly expressed in brain. 
# UCSC	uc003yti	human. [O43525-1]
# eggNOG	COG1226	LUCA
# eggNOG	KOG1419	Eukaryota
BLAST	swissprot:KCNQ3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNQ3_HUMAN
BioCyc	ZFISH:G66-33340-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33340-MONOMER
COXPRESdb	3786	http://coxpresdb.jp/data/gene/3786.shtml
CleanEx	HS_KCNQ3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNQ3
DOI	10.1002/1531-8249(200006)47:6<822::AID-ANA19>3.3.CO	http://dx.doi.org/10.1002/1531-8249(200006)47:6<822::AID-ANA19>3.3.CO
DOI	10.1016/S0014-5793(00)01918-9	http://dx.doi.org/10.1016/S0014-5793(00)01918-9
DOI	10.1016/S0304-3940(00)00866-1	http://dx.doi.org/10.1016/S0304-3940(00)00866-1
DOI	10.1038/25367	http://dx.doi.org/10.1038/25367
DOI	10.1038/nature04406	http://dx.doi.org/10.1038/nature04406
DOI	10.1038/ng0198-53	http://dx.doi.org/10.1038/ng0198-53
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.bjp.0703861	http://dx.doi.org/10.1038/sj.bjp.0703861
DOI	10.1073/pnas.0509122102	http://dx.doi.org/10.1073/pnas.0509122102
DOI	10.1074/jbc.273.31.19419	http://dx.doi.org/10.1074/jbc.273.31.19419
DOI	10.1074/jbc.275.18.13343	http://dx.doi.org/10.1074/jbc.275.18.13343
DOI	10.1093/brain/awg286	http://dx.doi.org/10.1093/brain/awg286
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1469-7793.2000.t01-2-00349.x	http://dx.doi.org/10.1111/j.1469-7793.2000.t01-2-00349.x
DOI	10.1111/j.1528-1167.2012.03516.x	http://dx.doi.org/10.1111/j.1528-1167.2012.03516.x
DrugBank	DB00321	http://www.drugbank.ca/drugs/DB00321
DrugBank	DB00586	http://www.drugbank.ca/drugs/DB00586
DrugBank	DB00939	http://www.drugbank.ca/drugs/DB00939
DrugBank	DB04953	http://www.drugbank.ca/drugs/DB04953
EMBL	AC018540	http://www.ebi.ac.uk/ena/data/view/AC018540
EMBL	AC123776	http://www.ebi.ac.uk/ena/data/view/AC123776
EMBL	AC131042	http://www.ebi.ac.uk/ena/data/view/AC131042
EMBL	AC136373	http://www.ebi.ac.uk/ena/data/view/AC136373
EMBL	AF033347	http://www.ebi.ac.uk/ena/data/view/AF033347
EMBL	AF071478	http://www.ebi.ac.uk/ena/data/view/AF071478
EMBL	AF071479	http://www.ebi.ac.uk/ena/data/view/AF071479
EMBL	AF071480	http://www.ebi.ac.uk/ena/data/view/AF071480
EMBL	AF071481	http://www.ebi.ac.uk/ena/data/view/AF071481
EMBL	AF071482	http://www.ebi.ac.uk/ena/data/view/AF071482
EMBL	AF071483	http://www.ebi.ac.uk/ena/data/view/AF071483
EMBL	AF071484	http://www.ebi.ac.uk/ena/data/view/AF071484
EMBL	AF071485	http://www.ebi.ac.uk/ena/data/view/AF071485
EMBL	AF071486	http://www.ebi.ac.uk/ena/data/view/AF071486
EMBL	AF071487	http://www.ebi.ac.uk/ena/data/view/AF071487
EMBL	AF071488	http://www.ebi.ac.uk/ena/data/view/AF071488
EMBL	AF071489	http://www.ebi.ac.uk/ena/data/view/AF071489
EMBL	AF071490	http://www.ebi.ac.uk/ena/data/view/AF071490
EMBL	AF071491	http://www.ebi.ac.uk/ena/data/view/AF071491
EMBL	AK296293	http://www.ebi.ac.uk/ena/data/view/AK296293
EMBL	BC128576	http://www.ebi.ac.uk/ena/data/view/BC128576
Ensembl	ENST00000388996	http://www.ensembl.org/id/ENST00000388996
Ensembl	ENST00000521134	http://www.ensembl.org/id/ENST00000521134
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0033268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033268
GO_component	GO:0043194	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043194
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0060081	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060081
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	KCNQ3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNQ3
GeneID	3786	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3786
GeneTree	ENSGT00550000074513	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074513
HGNC	HGNC:6297	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6297
HOGENOM	HOG000220839	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220839&db=HOGENOM6
HOVERGEN	HBG059014	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG059014&db=HOVERGEN
InParanoid	O43525	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O43525
InterPro	IPR003937	http://www.ebi.ac.uk/interpro/entry/IPR003937
InterPro	IPR003948	http://www.ebi.ac.uk/interpro/entry/IPR003948
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR013821	http://www.ebi.ac.uk/interpro/entry/IPR013821
InterPro	IPR020969	http://www.ebi.ac.uk/interpro/entry/IPR020969
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	3786	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3786
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00806	http://www.genome.jp/dbget-bin/www_bget?H00806
KEGG_Gene	hsa:3786	http://www.genome.jp/dbget-bin/www_bget?hsa:3786
KEGG_Orthology	KO:K04928	http://www.genome.jp/dbget-bin/www_bget?KO:K04928
KEGG_Pathway	ko04725	http://www.genome.jp/kegg-bin/show_pathway?ko04725
MIM	121201	http://www.ncbi.nlm.nih.gov/omim/121201
MIM	602232	http://www.ncbi.nlm.nih.gov/omim/602232
OMA	FFAHDPV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FFAHDPV
Orphanet	1949	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1949
Orphanet	306	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=306
Orphanet	307	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=307
OrthoDB	EOG091G02ZT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02ZT
PANTHER	PTHR11537	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537
PANTHER	PTHR11537:SF5	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537:SF5
PDB	5J03	http://www.ebi.ac.uk/pdbe-srv/view/entry/5J03
PDBsum	5J03	http://www.ebi.ac.uk/pdbsum/5J03
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01459	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01459
PRINTS	PR01462	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01462
PSORT	swissprot:KCNQ3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNQ3_HUMAN
PSORT-B	swissprot:KCNQ3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNQ3_HUMAN
PSORT2	swissprot:KCNQ3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNQ3_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF03520	http://pfam.xfam.org/family/PF03520
Pfam	PF11956	http://pfam.xfam.org/family/PF11956
PharmGKB	PA30075	http://www.pharmgkb.org/do/serve?objId=PA30075&objCls=Gene
Phobius	swissprot:KCNQ3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNQ3_HUMAN
PhylomeDB	O43525	http://phylomedb.org/?seqid=O43525
ProteinModelPortal	O43525	http://www.proteinmodelportal.org/query/uniprot/O43525
PubMed	10479678	http://www.ncbi.nlm.nih.gov/pubmed/10479678
PubMed	10684873	http://www.ncbi.nlm.nih.gov/pubmed/10684873
PubMed	10713399	http://www.ncbi.nlm.nih.gov/pubmed/10713399
PubMed	10713961	http://www.ncbi.nlm.nih.gov/pubmed/10713961
PubMed	10788442	http://www.ncbi.nlm.nih.gov/pubmed/10788442
PubMed	10852552	http://www.ncbi.nlm.nih.gov/pubmed/10852552
PubMed	10908292	http://www.ncbi.nlm.nih.gov/pubmed/10908292
PubMed	10953053	http://www.ncbi.nlm.nih.gov/pubmed/10953053
PubMed	11034315	http://www.ncbi.nlm.nih.gov/pubmed/11034315
PubMed	11159685	http://www.ncbi.nlm.nih.gov/pubmed/11159685
PubMed	14534157	http://www.ncbi.nlm.nih.gov/pubmed/14534157
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16319223	http://www.ncbi.nlm.nih.gov/pubmed/16319223
PubMed	16421571	http://www.ncbi.nlm.nih.gov/pubmed/16421571
PubMed	22612257	http://www.ncbi.nlm.nih.gov/pubmed/22612257
PubMed	9425900	http://www.ncbi.nlm.nih.gov/pubmed/9425900
PubMed	9677360	http://www.ncbi.nlm.nih.gov/pubmed/9677360
PubMed	9872318	http://www.ncbi.nlm.nih.gov/pubmed/9872318
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
Reactome	R-HSA-445095	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-445095
RefSeq	NP_001191753	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001191753
RefSeq	NP_004510	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004510
SMR	O43525	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O43525
STRING	9606.ENSP00000373648	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000373648&targetmode=cogs
TCDB	1.A.1.15	http://www.tcdb.org/search/result.php?tc=1.A.1.15
UCSC	uc003yti	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003yti&org=rat
UniGene	Hs.374023	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.374023
UniProtKB	KCNQ3_HUMAN	http://www.uniprot.org/uniprot/KCNQ3_HUMAN
UniProtKB-AC	O43525	http://www.uniprot.org/uniprot/O43525
charge	swissprot:KCNQ3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNQ3_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG1419	http://eggnogapi.embl.de/nog_data/html/tree/KOG1419
epestfind	swissprot:KCNQ3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNQ3_HUMAN
garnier	swissprot:KCNQ3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNQ3_HUMAN
helixturnhelix	swissprot:KCNQ3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNQ3_HUMAN
hmoment	swissprot:KCNQ3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNQ3_HUMAN
iep	swissprot:KCNQ3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNQ3_HUMAN
inforesidue	swissprot:KCNQ3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNQ3_HUMAN
neXtProt	NX_O43525	http://www.nextprot.org/db/entry/NX_O43525
octanol	swissprot:KCNQ3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNQ3_HUMAN
pepcoil	swissprot:KCNQ3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNQ3_HUMAN
pepdigest	swissprot:KCNQ3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNQ3_HUMAN
pepinfo	swissprot:KCNQ3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNQ3_HUMAN
pepnet	swissprot:KCNQ3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNQ3_HUMAN
pepstats	swissprot:KCNQ3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNQ3_HUMAN
pepwheel	swissprot:KCNQ3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNQ3_HUMAN
pepwindow	swissprot:KCNQ3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNQ3_HUMAN
sigcleave	swissprot:KCNQ3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNQ3_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	121691	3
# ChiTaRS	HCN3	human
# DOMAIN	HCN3_HUMAN	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. 
# ENZYME REGULATION	Inhibited by Cs(1+) and ZD7288. Is apparently not activated by cAMP. {ECO:0000269|PubMed	16043489}. 
# Ensembl	ENST00000368358	ENSP00000357342; ENSG00000143630
# Ensembl	ENST00000575670	ENSP00000458364; ENSG00000263324
# FUNCTION	HCN3_HUMAN	Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions. {ECO 0000269|PubMed 16043489}. 
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0030425	dendrite; IEA:Ensembl.
# GO_component	GO:0043025	neuronal cell body; IEA:Ensembl.
# GO_component	GO:0044316	cone cell pedicle; IEA:Ensembl.
# GO_component	GO:0045202	synapse; IEA:Ensembl.
# GO_function	GO:0005248	voltage-gated sodium channel activity; IMP:UniProtKB.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IMP:UniProtKB.
# GO_function	GO:0030552	cAMP binding; IEA:UniProtKB-KW.
# GO_process	GO:0035725	sodium ion transmembrane transport; IMP:UniProtKB.
# GO_process	GO:0042391	regulation of membrane potential; IMP:UniProtKB.
# GO_process	GO:0071805	potassium ion transmembrane transport; IMP:UniProtKB.
# GO_process	GO:0072718	response to cisplatin; IEA:Ensembl.
# GO_process	GO:1903351	cellular response to dopamine; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.120.10	-; 1.
# Genevisible	Q9P1Z3	HS
# HGNC	HGNC:19183	HCN3
# InterPro	IPR000595	cNMP-bd_dom
# InterPro	IPR003938	K_chnl_volt-dep_EAG/ELK/ERG
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR013621	Ion_trans_N
# InterPro	IPR014710	RmlC-like_jellyroll
# InterPro	IPR018490	cNMP-bd-like
# KEGG_Brite	ko04040	Ion channels
# MIM	609973	gene
# Organism	HCN3_HUMAN	Homo sapiens (Human)
# PRINTS	PR01463	EAGCHANLFMLY
# PROSITE	PS50042	CNMP_BINDING_3
# Pfam	PF00027	cNMP_binding
# Pfam	PF00520	Ion_trans
# Pfam	PF08412	Ion_trans_N
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-1296061	HCN channels
# RecName	HCN3_HUMAN	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
# RefSeq	NP_065948	NM_020897.2
# SEQUENCE CAUTION	Sequence=AAH28024.2; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the potassium channel HCN family. {ECO	0000305}. 
# SIMILARITY	Contains 1 cyclic nucleotide-binding domain. {ECO:0000255|PROSITE-ProRule	PRU00060}. 
# SMART	SM00100	cNMP
# SUBCELLULAR LOCATION	HCN3_HUMAN	Cell membrane {ECO 0000269|PubMed 16043489}; Multi-pass membrane protein {ECO 0000269|PubMed 16043489}. 
# SUBUNIT	Homotetramer. The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits (By similarity). {ECO	0000250}. 
# SUPFAM	SSF51206	SSF51206
# TISSUE SPECIFICITY	Detected in brain. {ECO:0000269|PubMed	16043489}. 
# UCSC	uc001fjz	human
# eggNOG	ENOG410XPSE	LUCA
# eggNOG	KOG0498	Eukaryota
BLAST	swissprot:HCN3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:HCN3_HUMAN
BioCyc	ZFISH:ENSG00000143630-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000143630-MONOMER
COXPRESdb	57657	http://coxpresdb.jp/data/gene/57657.shtml
CleanEx	HS_HCN3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_HCN3
DIP	DIP-62039N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-62039N
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1074/jbc.M502508200	http://dx.doi.org/10.1074/jbc.M502508200
DOI	10.1093/dnares/7.2.143	http://dx.doi.org/10.1093/dnares/7.2.143
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB040968	http://www.ebi.ac.uk/ena/data/view/AB040968
EMBL	AL713999	http://www.ebi.ac.uk/ena/data/view/AL713999
EMBL	BC000066	http://www.ebi.ac.uk/ena/data/view/BC000066
EMBL	BC028024	http://www.ebi.ac.uk/ena/data/view/BC028024
EMBL	CH471121	http://www.ebi.ac.uk/ena/data/view/CH471121
EMBL	CH471121	http://www.ebi.ac.uk/ena/data/view/CH471121
Ensembl	ENST00000368358	http://www.ensembl.org/id/ENST00000368358
Ensembl	ENST00000575670	http://www.ensembl.org/id/ENST00000575670
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0044316	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044316
GO_component	GO:0045202	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045202
GO_function	GO:0005248	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005248
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0030552	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030552
GO_process	GO:0035725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035725
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GO_process	GO:0072718	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072718
GO_process	GO:1903351	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903351
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.120.10	http://www.cathdb.info/version/latest/superfamily/2.60.120.10
GeneCards	HCN3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=HCN3
GeneID	57657	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57657
GeneTree	ENSGT00760000118772	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118772
H-InvDB	HIX0001125	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0001125
HGNC	HGNC:19183	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:19183
HOGENOM	HOG000230717	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230717&db=HOGENOM6
HOVERGEN	HBG039489	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG039489&db=HOVERGEN
HPA	HPA026584	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA026584
InParanoid	Q9P1Z3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9P1Z3
InterPro	IPR000595	http://www.ebi.ac.uk/interpro/entry/IPR000595
InterPro	IPR003938	http://www.ebi.ac.uk/interpro/entry/IPR003938
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR013621	http://www.ebi.ac.uk/interpro/entry/IPR013621
InterPro	IPR014710	http://www.ebi.ac.uk/interpro/entry/IPR014710
InterPro	IPR018490	http://www.ebi.ac.uk/interpro/entry/IPR018490
Jabion	57657	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=57657
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:57657	http://www.genome.jp/dbget-bin/www_bget?hsa:57657
KEGG_Orthology	KO:K04956	http://www.genome.jp/dbget-bin/www_bget?KO:K04956
MIM	609973	http://www.ncbi.nlm.nih.gov/omim/609973
OMA	VMEQHLV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VMEQHLV
OrthoDB	EOG091G0JQU	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0JQU
PRINTS	PR01463	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01463
PROSITE	PS50042	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50042
PSORT	swissprot:HCN3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:HCN3_HUMAN
PSORT-B	swissprot:HCN3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:HCN3_HUMAN
PSORT2	swissprot:HCN3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:HCN3_HUMAN
Pfam	PF00027	http://pfam.xfam.org/family/PF00027
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF08412	http://pfam.xfam.org/family/PF08412
PharmGKB	PA38821	http://www.pharmgkb.org/do/serve?objId=PA38821&objCls=Gene
Phobius	swissprot:HCN3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:HCN3_HUMAN
PhylomeDB	Q9P1Z3	http://phylomedb.org/?seqid=Q9P1Z3
ProteinModelPortal	Q9P1Z3	http://www.proteinmodelportal.org/query/uniprot/Q9P1Z3
PubMed	10819331	http://www.ncbi.nlm.nih.gov/pubmed/10819331
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16043489	http://www.ncbi.nlm.nih.gov/pubmed/16043489
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
Reactome	R-HSA-1296061	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296061
RefSeq	NP_065948	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_065948
SMART	SM00100	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00100
SMR	Q9P1Z3	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9P1Z3
STRING	9606.ENSP00000357342	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000357342&targetmode=cogs
SUPFAM	SSF51206	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51206
UCSC	uc001fjz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001fjz&org=rat
UniGene	Hs.706960	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.706960
UniProtKB	HCN3_HUMAN	http://www.uniprot.org/uniprot/HCN3_HUMAN
UniProtKB-AC	Q9P1Z3	http://www.uniprot.org/uniprot/Q9P1Z3
charge	swissprot:HCN3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:HCN3_HUMAN
eggNOG	ENOG410XPSE	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPSE
eggNOG	KOG0498	http://eggnogapi.embl.de/nog_data/html/tree/KOG0498
epestfind	swissprot:HCN3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:HCN3_HUMAN
garnier	swissprot:HCN3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:HCN3_HUMAN
helixturnhelix	swissprot:HCN3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:HCN3_HUMAN
hmoment	swissprot:HCN3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:HCN3_HUMAN
iep	swissprot:HCN3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:HCN3_HUMAN
inforesidue	swissprot:HCN3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:HCN3_HUMAN
neXtProt	NX_Q9P1Z3	http://www.nextprot.org/db/entry/NX_Q9P1Z3
octanol	swissprot:HCN3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:HCN3_HUMAN
pepcoil	swissprot:HCN3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:HCN3_HUMAN
pepdigest	swissprot:HCN3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:HCN3_HUMAN
pepinfo	swissprot:HCN3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:HCN3_HUMAN
pepnet	swissprot:HCN3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:HCN3_HUMAN
pepstats	swissprot:HCN3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:HCN3_HUMAN
pepwheel	swissprot:HCN3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:HCN3_HUMAN
pepwindow	swissprot:HCN3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:HCN3_HUMAN
sigcleave	swissprot:HCN3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:HCN3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ABCB5_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=4; IsoId=Q2M3G0-4; Sequence=Displayed; Name=2; Synonyms=ABCB5alpha; IsoId=Q2M3G0-2; Sequence=VSP_056752, VSP_056753, VSP_056756; Name=3; IsoId=Q2M3G0-3; Sequence=VSP_056752, VSP_056754, VSP_056755; Note=No experimental confirmation available.; Name=1; Synonyms=ABCB5beta; IsoId=Q2M3G0-1; Sequence=VSP_056752; 
# AltName	ABCB5_HUMAN	ABCB5 P-gp
# AltName	ABCB5_HUMAN	P-glycoprotein ABCB5
# BioGrid	131028	2
# CAUTION	Was named ABCB1 by some authors. {ECO	0000305}. 
# CCDS	CCDS5371	-. [Q2M3G0-1]
# CCDS	CCDS55090	-. [Q2M3G0-4]
# CCDS	CCDS55091	-. [Q2M3G0-2]
# CCDS	CCDS55092	-. [Q2M3G0-3]
# Ensembl	ENST00000258738	ENSP00000258738; ENSG00000004846. [Q2M3G0-1]
# Ensembl	ENST00000404938	ENSP00000384881; ENSG00000004846. [Q2M3G0-4]
# Ensembl	ENST00000406935	ENSP00000383899; ENSG00000004846. [Q2M3G0-3]
# Ensembl	ENST00000443026	ENSP00000406730; ENSG00000004846. [Q2M3G0-2]
# ExpressionAtlas	Q2M3G0	baseline and differential
# FUNCTION	ABCB5_HUMAN	Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair. {ECO 0000269|PubMed 12960149, ECO 0000269|PubMed 15205344, ECO 0000269|PubMed 15899824, ECO 0000269|PubMed 22306008}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0008559	xenobiotic-transporting ATPase activity; TAS:Reactome.
# GO_function	GO:0015562	efflux transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; IBA:GO_Central.
# GO_process	GO:0002481	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; IBA:GO_Central.
# GO_process	GO:0002485	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; IBA:GO_Central.
# GO_process	GO:0002489	antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; IBA:GO_Central.
# GO_process	GO:0002591	positive regulation of antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central.
# GO_process	GO:0030154	cell differentiation; IEA:UniProtKB-KW.
# GO_process	GO:0042391	regulation of membrane potential; IDA:UniProtKB.
# GO_process	GO:0048058	compound eye corneal lens development; ISS:UniProtKB.
# GO_process	GO:0055085	transmembrane transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 2.
# Genevisible	Q2M3G0	HS
# HGNC	HGNC:46	ABCB5
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR011527	ABC1_TM_dom
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko02010	ABC transporters
# MIM	611785	gene
# MISCELLANEOUS	ABCB5_HUMAN	Acts as a marker of stem-like cells (CSC) in a number of malignancies (PubMed 24934811). Associated with clinical drug resistance, tumor progression and disease recurrence in malignant melanoma and acute leukemias. Responsible for the resistance to doxorubicin of a subset of malignant melanomas. ABCB5-expressing cells selectively survive when exposed to dacarbazine drug, the reference treatment of metastatic melanoma, vemurafenib and other various chemotherapeutic drugs, suggesting that anti-melanoma chemotherapy participates in the chemoresistance acquisition by selecting tumor cell subpopulations expressing ABCB5 (PubMed 22784549, PubMed 22044138, PubMed 22675422, PubMed 23770371, PubMed 24934811). Present in melanoma-initiating cells that acts as an enhancer of tumor growth by promoting CSC maintenance and tumor growth by controlling IL- 1beta (IL1B) secretion to maintain slow-cycling, chemoresistant cells through an IL-1beta (IL1B)/IL8/CXCR1 cytokine signaling circuit (PubMed 24934811). {ECO 0000305|PubMed 22044138, ECO 0000305|PubMed 22675422, ECO 0000305|PubMed 22784549, ECO 0000305|PubMed 23770371, ECO 0000305|PubMed 24934811}. 
# Organism	ABCB5_HUMAN	Homo sapiens (Human)
# PROSITE	PS00211	ABC_TRANSPORTER_1; 2
# PROSITE	PS50893	ABC_TRANSPORTER_2; 2
# PROSITE	PS50929	ABC_TM1F
# Pfam	PF00005	ABC_tran; 2
# Pfam	PF00664	ABC_membrane; 2
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-382556	ABC-family proteins mediated transport
# RecName	ABCB5_HUMAN	ATP-binding cassette sub-family B member 5
# RefSeq	NP_001157413	NM_001163941.1. [Q2M3G0-4]
# RefSeq	NP_001157414	NM_001163942.1. [Q2M3G0-2]
# RefSeq	NP_001157465	NM_001163993.2. [Q2M3G0-3]
# RefSeq	NP_848654	NM_178559.5. [Q2M3G0-1]
# RefSeq	XP_011513669	XM_011515367.2. [Q2M3G0-1]
# SEQUENCE CAUTION	Sequence=AAN76500.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAQ03033.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 2 ABC transmembrane type-1 domains. {ECO:0000255|PROSITE-ProRule	PRU00441}. 
# SIMILARITY	Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA; 2
# SUBCELLULAR LOCATION	ABCB5_HUMAN	Cell membrane {ECO 0000269|PubMed 12960149}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00441, ECO 0000269|PubMed 12960149}. 
# SUPFAM	SSF52540	SSF52540; 2
# SUPFAM	SSF90123	SSF90123; 2
# TCDB	3.A.1.201.13	the atp-binding cassette (abc) superfamily
# TISSUE SPECIFICITY	ABCB5_HUMAN	Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Highly expressed in several malignant tissues  highly expressed in clinical melanomas, with low expression in normal skin. In melanoma, marks malignant melanoma-initiating cells (MMIC), in which clinical virulence resides as a consequence of unlimited self-renewal capacity, resulting in inexorable tumor progression and metastasis. Also highly expressed in a number of leukemia cells. Expressed in basal limbal epithelium. {ECO 0000269|PubMed 12960149, ECO 0000269|PubMed 15760339, ECO 0000269|PubMed 22044138, ECO 0000269|PubMed 22675422, ECO 0000269|PubMed 22784549, ECO 0000269|PubMed 23770371, ECO 0000269|PubMed 24934811, ECO 0000269|PubMed 25030174}. 
# UCSC	uc003suv	human. [Q2M3G0-4]
# WEB RESOURCE	ABCB5_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/ABCB5ID44305ch7p15.html";
# eggNOG	COG1132	LUCA
# eggNOG	KOG0055	Eukaryota
BLAST	swissprot:ABCB5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCB5_HUMAN
BioCyc	ZFISH:HS11997-MONOMER	http://biocyc.org/getid?id=ZFISH:HS11997-MONOMER
COXPRESdb	340273	http://coxpresdb.jp/data/gene/340273.shtml
CleanEx	HS_ABCB5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCB5
DOI	10.1016/j.bbrc.2012.01.090	http://dx.doi.org/10.1016/j.bbrc.2012.01.090
DOI	10.1016/j.bbrc.2013.06.006	http://dx.doi.org/10.1016/j.bbrc.2013.06.006
DOI	10.1016/j.ejca.2012.05.027	http://dx.doi.org/10.1016/j.ejca.2012.05.027
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1038/nature13426	http://dx.doi.org/10.1038/nature13426
DOI	10.1074/jbc.M308700200	http://dx.doi.org/10.1074/jbc.M308700200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1600-0749.2005.00214.x	http://dx.doi.org/10.1111/j.1600-0749.2005.00214.x
DOI	10.1126/science.1083423	http://dx.doi.org/10.1126/science.1083423
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1126/science.1164368	http://dx.doi.org/10.1126/science.1164368
DOI	10.1158/0008-5472.CAN-03-3884	http://dx.doi.org/10.1158/0008-5472.CAN-03-3884
DOI	10.1158/0008-5472.CAN-04-3327	http://dx.doi.org/10.1158/0008-5472.CAN-04-3327
DOI	10.1158/0008-5472.CAN-11-0221	http://dx.doi.org/10.1158/0008-5472.CAN-11-0221
DOI	10.1158/0008-5472.CAN-14-0582	http://dx.doi.org/10.1158/0008-5472.CAN-14-0582
DOI	10.1371/journal.pone.0036762	http://dx.doi.org/10.1371/journal.pone.0036762
DOI	10.3109/10428194.2011.637214	http://dx.doi.org/10.3109/10428194.2011.637214
EMBL	AB353947	http://www.ebi.ac.uk/ena/data/view/AB353947
EMBL	AC002486	http://www.ebi.ac.uk/ena/data/view/AC002486
EMBL	AC005060	http://www.ebi.ac.uk/ena/data/view/AC005060
EMBL	AF319622	http://www.ebi.ac.uk/ena/data/view/AF319622
EMBL	AF399931	http://www.ebi.ac.uk/ena/data/view/AF399931
EMBL	AY090613	http://www.ebi.ac.uk/ena/data/view/AY090613
EMBL	AY230001	http://www.ebi.ac.uk/ena/data/view/AY230001
EMBL	AY234788	http://www.ebi.ac.uk/ena/data/view/AY234788
EMBL	AY851364	http://www.ebi.ac.uk/ena/data/view/AY851364
EMBL	AY851365	http://www.ebi.ac.uk/ena/data/view/AY851365
EMBL	BC104894	http://www.ebi.ac.uk/ena/data/view/BC104894
EMBL	BC104920	http://www.ebi.ac.uk/ena/data/view/BC104920
EMBL	BC110370	http://www.ebi.ac.uk/ena/data/view/BC110370
EMBL	CH236948	http://www.ebi.ac.uk/ena/data/view/CH236948
EMBL	CH471073	http://www.ebi.ac.uk/ena/data/view/CH471073
EMBL	GU437216	http://www.ebi.ac.uk/ena/data/view/GU437216
EMBL	GU437217	http://www.ebi.ac.uk/ena/data/view/GU437217
Ensembl	ENST00000258738	http://www.ensembl.org/id/ENST00000258738
Ensembl	ENST00000404938	http://www.ensembl.org/id/ENST00000404938
Ensembl	ENST00000406935	http://www.ensembl.org/id/ENST00000406935
Ensembl	ENST00000443026	http://www.ensembl.org/id/ENST00000443026
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0008559	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008559
GO_function	GO:0015562	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015562
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GO_process	GO:0002481	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002481
GO_process	GO:0002485	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002485
GO_process	GO:0002489	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002489
GO_process	GO:0002591	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002591
GO_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0048058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048058
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCB5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCB5
GeneID	340273	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=340273
GeneTree	ENSGT00530000062896	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062896
H-InvDB	HIX0025281	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0025281
HGNC	HGNC:46	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:46
HOVERGEN	HBG080809	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG080809&db=HOVERGEN
HPA	HPA026975	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA026975
InParanoid	Q2M3G0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q2M3G0
IntAct	Q2M3G0	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q2M3G0*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR011527	http://www.ebi.ac.uk/interpro/entry/IPR011527
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	340273	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=340273
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:340273	http://www.genome.jp/dbget-bin/www_bget?hsa:340273
KEGG_Orthology	KO:K05660	http://www.genome.jp/dbget-bin/www_bget?KO:K05660
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
MIM	611785	http://www.ncbi.nlm.nih.gov/omim/611785
OMA	YCIGAAV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YCIGAAV
OrthoDB	EOG091G0HVA	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0HVA
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PROSITE	PS50929	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929
PSORT	swissprot:ABCB5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCB5_HUMAN
PSORT-B	swissprot:ABCB5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCB5_HUMAN
PSORT2	swissprot:ABCB5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCB5_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF00664	http://pfam.xfam.org/family/PF00664
PharmGKB	PA24387	http://www.pharmgkb.org/do/serve?objId=PA24387&objCls=Gene
Phobius	swissprot:ABCB5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCB5_HUMAN
PhylomeDB	Q2M3G0	http://phylomedb.org/?seqid=Q2M3G0
ProteinModelPortal	Q2M3G0	http://www.proteinmodelportal.org/query/uniprot/Q2M3G0
PubMed	12690205	http://www.ncbi.nlm.nih.gov/pubmed/12690205
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	12960149	http://www.ncbi.nlm.nih.gov/pubmed/12960149
PubMed	15205344	http://www.ncbi.nlm.nih.gov/pubmed/15205344
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15760339	http://www.ncbi.nlm.nih.gov/pubmed/15760339
PubMed	15899824	http://www.ncbi.nlm.nih.gov/pubmed/15899824
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	18772397	http://www.ncbi.nlm.nih.gov/pubmed/18772397
PubMed	21652540	http://www.ncbi.nlm.nih.gov/pubmed/21652540
PubMed	22044138	http://www.ncbi.nlm.nih.gov/pubmed/22044138
PubMed	22306008	http://www.ncbi.nlm.nih.gov/pubmed/22306008
PubMed	22675422	http://www.ncbi.nlm.nih.gov/pubmed/22675422
PubMed	22784549	http://www.ncbi.nlm.nih.gov/pubmed/22784549
PubMed	23770371	http://www.ncbi.nlm.nih.gov/pubmed/23770371
PubMed	24934811	http://www.ncbi.nlm.nih.gov/pubmed/24934811
PubMed	25030174	http://www.ncbi.nlm.nih.gov/pubmed/25030174
Reactome	R-HSA-382556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-382556
RefSeq	NP_001157413	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001157413
RefSeq	NP_001157414	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001157414
RefSeq	NP_001157465	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001157465
RefSeq	NP_848654	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_848654
RefSeq	XP_011513669	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011513669
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	Q2M3G0	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q2M3G0
STRING	9606.ENSP00000384881	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000384881&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
SUPFAM	SSF90123	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123
TCDB	3.A.1.201.13	http://www.tcdb.org/search/result.php?tc=3.A.1.201.13
UCSC	uc003suv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003suv&org=rat
UniGene	Hs.404102	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.404102
UniProtKB	ABCB5_HUMAN	http://www.uniprot.org/uniprot/ABCB5_HUMAN
UniProtKB-AC	Q2M3G0	http://www.uniprot.org/uniprot/Q2M3G0
charge	swissprot:ABCB5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCB5_HUMAN
eggNOG	COG1132	http://eggnogapi.embl.de/nog_data/html/tree/COG1132
eggNOG	KOG0055	http://eggnogapi.embl.de/nog_data/html/tree/KOG0055
epestfind	swissprot:ABCB5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCB5_HUMAN
garnier	swissprot:ABCB5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCB5_HUMAN
helixturnhelix	swissprot:ABCB5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCB5_HUMAN
hmoment	swissprot:ABCB5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCB5_HUMAN
iep	swissprot:ABCB5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCB5_HUMAN
inforesidue	swissprot:ABCB5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCB5_HUMAN
neXtProt	NX_Q2M3G0	http://www.nextprot.org/db/entry/NX_Q2M3G0
octanol	swissprot:ABCB5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCB5_HUMAN
pepcoil	swissprot:ABCB5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCB5_HUMAN
pepdigest	swissprot:ABCB5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCB5_HUMAN
pepinfo	swissprot:ABCB5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCB5_HUMAN
pepnet	swissprot:ABCB5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCB5_HUMAN
pepstats	swissprot:ABCB5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCB5_HUMAN
pepwheel	swissprot:ABCB5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCB5_HUMAN
pepwindow	swissprot:ABCB5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCB5_HUMAN
sigcleave	swissprot:ABCB5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCB5_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	MCU_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8NE86-1; Sequence=Displayed; Name=2; IsoId=Q8NE86-2; Sequence=VSP_024263; Note=No experimental confirmation available.; Name=3; IsoId=Q8NE86-3; Sequence=VSP_041687; 
# AltName	Coiled-coil domain-containing protein 109A {ECO	0000305}
# BioGrid	124733	30
# CCDS	CCDS59218	-. [Q8NE86-2]
# CCDS	CCDS59219	-. [Q8NE86-3]
# CCDS	CCDS7317	-. [Q8NE86-1]
# ChiTaRS	MCU	human
# DOMAIN	MCU_HUMAN	Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region  while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH). {ECO 0000250|UniProtKB Q21121}. 
# DOMAIN	MCU_HUMAN	The N-terminal MCU domain is required for efficient Ca(2+) uptake and for interaction with MCUR1. It is not required for targeting to the mitochondria, oligomerization, interaction with MICU1 and MICU2, or assembly of the uniplex complex. {ECO 0000269|PubMed 26341627}. 
# DOMAIN	MCU_HUMAN	The critical DXXE motif connecting the transmembrane regions forms a pentameric barrel that constitutes the mouth of the pore. Inside the barrel, two acidic residues are in position to form two carboxylate rings. In absence of SMDT1/EMRE regulator, the calcium ions cannot exit the channel, suggesting that SMDT1/EMRE-binding induces conformational rearrangements to allow calcium to exit. {ECO 0000250|UniProtKB Q21121}. 
# ENZYME REGULATION	Inhibited by ruthenium red or its derivative Ru360. {ECO:0000269|PubMed	23755363}. 
# Ensembl	ENST00000357157	ENSP00000349680; ENSG00000156026. [Q8NE86-2]
# Ensembl	ENST00000373053	ENSP00000362144; ENSG00000156026. [Q8NE86-1]
# Ensembl	ENST00000536019	ENSP00000440913; ENSG00000156026. [Q8NE86-3]
# ExpressionAtlas	Q8NE86	baseline and differential
# FUNCTION	MCU_HUMAN	Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria (PubMed 21685888, PubMed 21685886, PubMed 23101630, PubMed 22904319, PubMed 23178883, PubMed 22829870, PubMed 22822213, PubMed 24332854, PubMed 23755363, PubMed 26341627). Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) (PubMed 23755363). Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down- regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity (PubMed 24560927, PubMed 26903221). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes (PubMed 22822213). While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short- term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress  acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells (PubMed 25603276). participates in mitochondrial permeability transition during ischemia-reperfusion injury (By similarity). Regulates glucose- dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed 22904319, PubMed 22829870). Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults (By similarity). Regulates synaptic vesicle endocytosis kinetics in central nerve terminal (By similarity). Involved in antigen processing and presentation (By similarity). {ECO 0000250|UniProtKB Q3UMR5, ECO 0000269|PubMed 21685886, ECO 0000269|PubMed 21685888, ECO 0000269|PubMed 22822213, ECO 0000269|PubMed 22829870, ECO 0000269|PubMed 22904319, ECO 0000269|PubMed 23101630, ECO 0000269|PubMed 23178883, ECO 0000269|PubMed 23755363, ECO 0000269|PubMed 24332854, ECO 0000269|PubMed 24560927, ECO 0000269|PubMed 25603276, ECO 0000269|PubMed 26341627, ECO 0000269|PubMed 26903221}. 
# GO_component	GO:0005739	mitochondrion; IDA:HPA.
# GO_component	GO:0005743	mitochondrial inner membrane; IDA:UniProtKB.
# GO_component	GO:0031305	integral component of mitochondrial inner membrane; IDA:UniProtKB.
# GO_component	GO:0034704	calcium channel complex; IDA:UniProtKB.
# GO_component	GO:1990246	uniplex complex; IDA:UniProtKB.
# GO_function	GO:0005262	calcium channel activity; IDA:UniProtKB.
# GO_function	GO:0015292	uniporter activity; IDA:UniProtKB.
# GO_process	GO:0006851	mitochondrial calcium ion transport; IDA:UniProtKB.
# GO_process	GO:0019722	calcium-mediated signaling; IDA:UniProtKB.
# GO_process	GO:0032024	positive regulation of insulin secretion; IMP:UniProtKB.
# GO_process	GO:0035786	protein complex oligomerization; IDA:UniProtKB.
# GO_process	GO:0036444	calcium ion transmembrane import into mitochondrion; IMP:UniProtKB.
# GO_process	GO:0042593	glucose homeostasis; IMP:UniProtKB.
# GO_process	GO:0051561	positive regulation of mitochondrial calcium ion concentration; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q8NE86	HS
# HGNC	HGNC:23526	MCU
# INDUCTION	MCU_HUMAN	MCU transcripts are down-regulated by microRNA miR-25 (PubMed 23246404). Down-regulation by miR-25 may protect cardiomyocytes against oxidative damage in cardiomyocytes (PubMed 25764156). {ECO 0000269|PubMed 23246404, ECO 0000269|PubMed 25764156}. 
# IntAct	Q8NE86	11
# InterPro	IPR006769	Coiled-coil-dom_prot_109_C
# MIM	614197	gene
# Organism	MCU_HUMAN	Homo sapiens (Human)
# PDB	4XSJ	X-ray; 1.80 A; A=75-165
# PDB	4XTB	X-ray; 1.50 A; A=75-185
# PDB	5BZ6	X-ray; 2.75 A; A=75-165
# PDB	5KUE	X-ray; 1.50 A; A=72-189
# PDB	5KUG	X-ray; 1.90 A; A=72-189
# PDB	5KUI	X-ray; 2.70 A; A=72-189
# PDB	5KUJ	X-ray; 1.60 A; A=72-189
# PTM	MCU_HUMAN	Phosphorylation by CaMK2 in heart leads to increased MCU current (PubMed 23051746, PubMed 25254481). The regulation of MCU by CaMK2 is however subject to discussion  another group was unable to reproduce these results (PubMed 25254480). Phosphorylated on tyrosines by PTK2B/PYK2, promoting oligomerization (PubMed 24800979). {ECO 0000269|PubMed 24800979, ECO 0000305|PubMed 23051746, ECO 0000305|PubMed 25254480, ECO 0000305|PubMed 25254481}. 
# Pfam	PF04678	MCU
# Proteomes	UP000005640	Chromosome 10
# RecName	Calcium uniporter protein, mitochondrial {ECO:0000303|PubMed	21685886}
# RefSeq	NP_001257608	NM_001270679.1. [Q8NE86-2]
# RefSeq	NP_001257609	NM_001270680.1. [Q8NE86-3]
# RefSeq	NP_612366	NM_138357.2. [Q8NE86-1]
# SIMILARITY	Belongs to the MCU (TC 1.A.77) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	MCU_HUMAN	Mitochondrion inner membrane {ECO 0000269|PubMed 21685886, ECO 0000269|PubMed 21685888, ECO 0000269|PubMed 23755363, ECO 0000269|PubMed 24231807, ECO 0000269|PubMed 27099988, ECO 0000305|PubMed 26341627}; Multi- pass membrane protein {ECO 0000269|PubMed 21685886, ECO 0000269|PubMed 21685888, ECO 0000269|PubMed 24231807}. 
# SUBUNIT	MCU_HUMAN	Component of the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1 (PubMed 24231807). Homooligomer (PubMed 21685886, PubMed 26341627). Forms a pentamer (By similarity). Heterooligomer with CCDC109B/MCUB; this inhibits channel activity (By similarity). Interacts with MICU1; MICU1 acts as an essential regulator for MCU (PubMed 21685886, PubMed 23101630, PubMed 23178883, PubMed 24332854, PubMed 26341627). Interacts with MCUR1 (PubMed 23178883, PubMed 26341627, PubMed 27184846, PubMed 26976564). Interacts with CCDC90B (PubMed 27184846). Interactions with MICU1 and MCUR1 are mutually exclusive (PubMed 23178883). Interacts with MICU2 (PubMed 26341627). Interacts with SLC25A23 (PubMed 24430870). {ECO 0000250|UniProtKB Q21121, ECO 0000250|UniProtKB Q3UMR5, ECO 0000269|PubMed 21685886, ECO 0000269|PubMed 23101630, ECO 0000269|PubMed 23178883, ECO 0000269|PubMed 24231807, ECO 0000269|PubMed 24332854, ECO 0000269|PubMed 24430870, ECO 0000269|PubMed 26341627, ECO 0000269|PubMed 26976564, ECO 0000269|PubMed 27184846}. 
# TopDownProteomics	Q8NE86-3	-. [Q8NE86-3]
# UCSC	uc001jtc	human. [Q8NE86-1]
# eggNOG	ENOG410Y3YU	LUCA
# eggNOG	KOG2966	Eukaryota
BLAST	swissprot:MCU_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MCU_HUMAN
BioCyc	ZFISH:ENSG00000156026-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000156026-MONOMER
BioCyc	ZFISH:MONOMER66-34413	http://biocyc.org/getid?id=ZFISH:MONOMER66-34413
COXPRESdb	90550	http://coxpresdb.jp/data/gene/90550.shtml
CleanEx	HS_CCDC109A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CCDC109A
DIP	DIP-60468N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-60468N
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.bbamem.2016.02.022	http://dx.doi.org/10.1016/j.bbamem.2016.02.022
DOI	10.1016/j.cell.2012.10.011	http://dx.doi.org/10.1016/j.cell.2012.10.011
DOI	10.1016/j.celrep.2013.11.026	http://dx.doi.org/10.1016/j.celrep.2013.11.026
DOI	10.1016/j.celrep.2016.04.050	http://dx.doi.org/10.1016/j.celrep.2016.04.050
DOI	10.1016/j.cub.2012.11.026	http://dx.doi.org/10.1016/j.cub.2012.11.026
DOI	10.1016/j.molcel.2014.01.013	http://dx.doi.org/10.1016/j.molcel.2014.01.013
DOI	10.1038/nature02462	http://dx.doi.org/10.1038/nature02462
DOI	10.1038/nature10230	http://dx.doi.org/10.1038/nature10230
DOI	10.1038/nature10234	http://dx.doi.org/10.1038/nature10234
DOI	10.1038/nature11444	http://dx.doi.org/10.1038/nature11444
DOI	10.1038/nature13626	http://dx.doi.org/10.1038/nature13626
DOI	10.1038/nature13627	http://dx.doi.org/10.1038/nature13627
DOI	10.1038/nature17656	http://dx.doi.org/10.1038/nature17656
DOI	10.1038/ncb2622	http://dx.doi.org/10.1038/ncb2622
DOI	10.1038/ncomms7081	http://dx.doi.org/10.1038/ncomms7081
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.1210718109	http://dx.doi.org/10.1073/pnas.1210718109
DOI	10.1073/pnas.1602264113	http://dx.doi.org/10.1073/pnas.1602264113
DOI	10.1074/jbc.M112.392084	http://dx.doi.org/10.1074/jbc.M112.392084
DOI	10.1089/ars.2013.5394	http://dx.doi.org/10.1089/ars.2013.5394
DOI	10.1091/mbc.E13-08-0502	http://dx.doi.org/10.1091/mbc.E13-08-0502
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1214977	http://dx.doi.org/10.1126/science.1214977
DOI	10.1126/science.1242993	http://dx.doi.org/10.1126/science.1242993
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1371/journal.pone.0039722	http://dx.doi.org/10.1371/journal.pone.0039722
DOI	10.15252/embr.201540436	http://dx.doi.org/10.15252/embr.201540436
DOI	10.3390/ijms16035420	http://dx.doi.org/10.3390/ijms16035420
DOI	10.7554/eLife.00704	http://dx.doi.org/10.7554/eLife.00704
DOI	10.7554/eLife.15545	http://dx.doi.org/10.7554/eLife.15545
EMBL	AC016542	http://www.ebi.ac.uk/ena/data/view/AC016542
EMBL	AC069548	http://www.ebi.ac.uk/ena/data/view/AC069548
EMBL	AK128016	http://www.ebi.ac.uk/ena/data/view/AK128016
EMBL	AK315519	http://www.ebi.ac.uk/ena/data/view/AK315519
EMBL	BC010682	http://www.ebi.ac.uk/ena/data/view/BC010682
EMBL	BC034235	http://www.ebi.ac.uk/ena/data/view/BC034235
EMBL	CH471083	http://www.ebi.ac.uk/ena/data/view/CH471083
Ensembl	ENST00000357157	http://www.ensembl.org/id/ENST00000357157
Ensembl	ENST00000373053	http://www.ensembl.org/id/ENST00000373053
Ensembl	ENST00000536019	http://www.ensembl.org/id/ENST00000536019
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0031305	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031305
GO_component	GO:0034704	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034704
GO_component	GO:1990246	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990246
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0015292	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015292
GO_process	GO:0006851	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006851
GO_process	GO:0019722	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019722
GO_process	GO:0032024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032024
GO_process	GO:0035786	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035786
GO_process	GO:0036444	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036444
GO_process	GO:0042593	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042593
GO_process	GO:0051561	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051561
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	MCU	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=MCU
GeneID	90550	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=90550
GeneTree	ENSGT00390000004496	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000004496
HGNC	HGNC:23526	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:23526
HOGENOM	HOG000008081	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000008081&db=HOGENOM6
HOVERGEN	HBG060246	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG060246&db=HOVERGEN
HPA	HPA016480	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA016480
InParanoid	Q8NE86	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8NE86
IntAct	Q8NE86	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8NE86*
InterPro	IPR006769	http://www.ebi.ac.uk/interpro/entry/IPR006769
Jabion	90550	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=90550
KEGG_Gene	hsa:90550	http://www.genome.jp/dbget-bin/www_bget?hsa:90550
MIM	614197	http://www.ncbi.nlm.nih.gov/omim/614197
MINT	MINT-8051705	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8051705
OMA	GAVYCST	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GAVYCST
OrthoDB	EOG091G092C	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G092C
PDB	4XSJ	http://www.ebi.ac.uk/pdbe-srv/view/entry/4XSJ
PDB	4XTB	http://www.ebi.ac.uk/pdbe-srv/view/entry/4XTB
PDB	5BZ6	http://www.ebi.ac.uk/pdbe-srv/view/entry/5BZ6
PDB	5KUE	http://www.ebi.ac.uk/pdbe-srv/view/entry/5KUE
PDB	5KUG	http://www.ebi.ac.uk/pdbe-srv/view/entry/5KUG
PDB	5KUI	http://www.ebi.ac.uk/pdbe-srv/view/entry/5KUI
PDB	5KUJ	http://www.ebi.ac.uk/pdbe-srv/view/entry/5KUJ
PDBsum	4XSJ	http://www.ebi.ac.uk/pdbsum/4XSJ
PDBsum	4XTB	http://www.ebi.ac.uk/pdbsum/4XTB
PDBsum	5BZ6	http://www.ebi.ac.uk/pdbsum/5BZ6
PDBsum	5KUE	http://www.ebi.ac.uk/pdbsum/5KUE
PDBsum	5KUG	http://www.ebi.ac.uk/pdbsum/5KUG
PDBsum	5KUI	http://www.ebi.ac.uk/pdbsum/5KUI
PDBsum	5KUJ	http://www.ebi.ac.uk/pdbsum/5KUJ
PSORT	swissprot:MCU_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MCU_HUMAN
PSORT-B	swissprot:MCU_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MCU_HUMAN
PSORT2	swissprot:MCU_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MCU_HUMAN
Pfam	PF04678	http://pfam.xfam.org/family/PF04678
PharmGKB	PA134888841	http://www.pharmgkb.org/do/serve?objId=PA134888841&objCls=Gene
Phobius	swissprot:MCU_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MCU_HUMAN
PhylomeDB	Q8NE86	http://phylomedb.org/?seqid=Q8NE86
ProteinModelPortal	Q8NE86	http://www.proteinmodelportal.org/query/uniprot/Q8NE86
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15164054	http://www.ncbi.nlm.nih.gov/pubmed/15164054
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21685886	http://www.ncbi.nlm.nih.gov/pubmed/21685886
PubMed	21685888	http://www.ncbi.nlm.nih.gov/pubmed/21685888
PubMed	22605770	http://www.ncbi.nlm.nih.gov/pubmed/22605770
PubMed	22822213	http://www.ncbi.nlm.nih.gov/pubmed/22822213
PubMed	22829870	http://www.ncbi.nlm.nih.gov/pubmed/22829870
PubMed	22904319	http://www.ncbi.nlm.nih.gov/pubmed/22904319
PubMed	23051746	http://www.ncbi.nlm.nih.gov/pubmed/23051746
PubMed	23101630	http://www.ncbi.nlm.nih.gov/pubmed/23101630
PubMed	23178883	http://www.ncbi.nlm.nih.gov/pubmed/23178883
PubMed	23246404	http://www.ncbi.nlm.nih.gov/pubmed/23246404
PubMed	23755363	http://www.ncbi.nlm.nih.gov/pubmed/23755363
PubMed	24231807	http://www.ncbi.nlm.nih.gov/pubmed/24231807
PubMed	24332854	http://www.ncbi.nlm.nih.gov/pubmed/24332854
PubMed	24430870	http://www.ncbi.nlm.nih.gov/pubmed/24430870
PubMed	24560927	http://www.ncbi.nlm.nih.gov/pubmed/24560927
PubMed	24800979	http://www.ncbi.nlm.nih.gov/pubmed/24800979
PubMed	25254480	http://www.ncbi.nlm.nih.gov/pubmed/25254480
PubMed	25254481	http://www.ncbi.nlm.nih.gov/pubmed/25254481
PubMed	25603276	http://www.ncbi.nlm.nih.gov/pubmed/25603276
PubMed	25764156	http://www.ncbi.nlm.nih.gov/pubmed/25764156
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	26341627	http://www.ncbi.nlm.nih.gov/pubmed/26341627
PubMed	26903221	http://www.ncbi.nlm.nih.gov/pubmed/26903221
PubMed	26976564	http://www.ncbi.nlm.nih.gov/pubmed/26976564
PubMed	27099988	http://www.ncbi.nlm.nih.gov/pubmed/27099988
PubMed	27135929	http://www.ncbi.nlm.nih.gov/pubmed/27135929
PubMed	27184846	http://www.ncbi.nlm.nih.gov/pubmed/27184846
RefSeq	NP_001257608	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001257608
RefSeq	NP_001257609	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001257609
RefSeq	NP_612366	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_612366
SMR	Q8NE86	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8NE86
STRING	9606.ENSP00000362144	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000362144&targetmode=cogs
UCSC	uc001jtc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001jtc&org=rat
UniGene	Hs.591366	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.591366
UniProtKB	MCU_HUMAN	http://www.uniprot.org/uniprot/MCU_HUMAN
UniProtKB-AC	Q8NE86	http://www.uniprot.org/uniprot/Q8NE86
charge	swissprot:MCU_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MCU_HUMAN
eggNOG	ENOG410Y3YU	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y3YU
eggNOG	KOG2966	http://eggnogapi.embl.de/nog_data/html/tree/KOG2966
epestfind	swissprot:MCU_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MCU_HUMAN
garnier	swissprot:MCU_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MCU_HUMAN
helixturnhelix	swissprot:MCU_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MCU_HUMAN
hmoment	swissprot:MCU_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MCU_HUMAN
iep	swissprot:MCU_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MCU_HUMAN
inforesidue	swissprot:MCU_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MCU_HUMAN
neXtProt	NX_Q8NE86	http://www.nextprot.org/db/entry/NX_Q8NE86
octanol	swissprot:MCU_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MCU_HUMAN
pepcoil	swissprot:MCU_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MCU_HUMAN
pepdigest	swissprot:MCU_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MCU_HUMAN
pepinfo	swissprot:MCU_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MCU_HUMAN
pepnet	swissprot:MCU_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MCU_HUMAN
pepstats	swissprot:MCU_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MCU_HUMAN
pepwheel	swissprot:MCU_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MCU_HUMAN
pepwindow	swissprot:MCU_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MCU_HUMAN
sigcleave	swissprot:MCU_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MCU_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ABCG1_HUMAN	Event=Alternative splicing; Named isoforms=8; Comment=Additional isoforms seem to exist.; Name=1; IsoId=P45844-1; Sequence=Displayed; Name=2; Synonyms=J; IsoId=P45844-2; Sequence=VSP_000047, VSP_000051; Name=3; Synonyms=ABDE; IsoId=P45844-3; Sequence=VSP_000048, VSP_000051; Name=4; Synonyms=G; IsoId=P45844-4; Sequence=VSP_000051; Name=5; Synonyms=F; IsoId=P45844-5; Sequence=VSP_000049, VSP_000051; Name=6; Synonyms=HI; IsoId=P45844-6; Sequence=VSP_000046, VSP_000051; Name=7; Synonyms=C; IsoId=P45844-7; Sequence=VSP_000050, VSP_000051; Name=8; IsoId=P45844-8; Sequence=VSP_010718; 
# AltName	ABCG1_HUMAN	ATP-binding cassette transporter 8
# AltName	ABCG1_HUMAN	White protein homolog
# BioGrid	114980	59
# CCDS	CCDS13681	-. [P45844-5]
# CCDS	CCDS13682	-. [P45844-1]
# CCDS	CCDS13683	-. [P45844-2]
# CCDS	CCDS42937	-. [P45844-3]
# CCDS	CCDS42938	-. [P45844-4]
# ChiTaRS	ABCG1	human
# DrugBank	DB00171	Adenosine triphosphate
# Ensembl	ENST00000343687	ENSP00000339744; ENSG00000160179. [P45844-2]
# Ensembl	ENST00000347800	ENSP00000291524; ENSG00000160179. [P45844-5]
# Ensembl	ENST00000361802	ENSP00000354995; ENSG00000160179. [P45844-1]
# Ensembl	ENST00000398449	ENSP00000381467; ENSG00000160179. [P45844-4]
# Ensembl	ENST00000398457	ENSP00000381475; ENSG00000160179. [P45844-3]
# ExpressionAtlas	P45844	baseline and differential
# FUNCTION	ABCG1_HUMAN	Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. 
# GO_component	GO:0000139	Golgi membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005654	nucleoplasm; IDA:HPA.
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005768	endosome; ISS:BHF-UCL.
# GO_component	GO:0005789	endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005794	Golgi apparatus; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IC:UniProtKB.
# GO_component	GO:0009897	external side of plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0016021	integral component of membrane; IBA:GO_Central.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_component	GO:0055037	recycling endosome; ISS:BHF-UCL.
# GO_function	GO:0005524	ATP binding; IDA:BHF-UCL.
# GO_function	GO:0005543	phospholipid binding; IC:BHF-UCL.
# GO_function	GO:0005548	phospholipid transporter activity; IDA:BHF-UCL.
# GO_function	GO:0015485	cholesterol binding; IC:BHF-UCL.
# GO_function	GO:0017127	cholesterol transporter activity; IDA:BHF-UCL.
# GO_function	GO:0019534	toxin transporter activity; IDA:BHF-UCL.
# GO_function	GO:0034041	sterol-transporting ATPase activity; IDA:BHF-UCL.
# GO_function	GO:0034437	glycoprotein transporter activity; IDA:BHF-UCL.
# GO_function	GO:0042803	protein homodimerization activity; IDA:BHF-UCL.
# GO_function	GO:0043531	ADP binding; IDA:BHF-UCL.
# GO_function	GO:0046982	protein heterodimerization activity; IPI:BHF-UCL.
# GO_function	GO:0046983	protein dimerization activity; NAS:UniProtKB.
# GO_process	GO:0006355	regulation of transcription, DNA-templated; ISS:BHF-UCL.
# GO_process	GO:0008203	cholesterol metabolic process; IDA:BHF-UCL.
# GO_process	GO:0009720	detection of hormone stimulus; NAS:UniProtKB.
# GO_process	GO:0010033	response to organic substance; IDA:UniProtKB.
# GO_process	GO:0010745	negative regulation of macrophage derived foam cell differentiation; TAS:BHF-UCL.
# GO_process	GO:0010872	regulation of cholesterol esterification; ISS:BHF-UCL.
# GO_process	GO:0010875	positive regulation of cholesterol efflux; IEA:Ensembl.
# GO_process	GO:0010887	negative regulation of cholesterol storage; TAS:BHF-UCL.
# GO_process	GO:0032367	intracellular cholesterol transport; IMP:BHF-UCL.
# GO_process	GO:0033344	cholesterol efflux; IDA:BHF-UCL.
# GO_process	GO:0033700	phospholipid efflux; IMP:BHF-UCL.
# GO_process	GO:0033993	response to lipid; IDA:BHF-UCL.
# GO_process	GO:0034374	low-density lipoprotein particle remodeling; ISS:BHF-UCL.
# GO_process	GO:0034375	high-density lipoprotein particle remodeling; ISS:BHF-UCL.
# GO_process	GO:0034436	glycoprotein transport; IDA:BHF-UCL.
# GO_process	GO:0042157	lipoprotein metabolic process; TAS:Reactome.
# GO_process	GO:0042632	cholesterol homeostasis; IDA:BHF-UCL.
# GO_process	GO:0042987	amyloid precursor protein catabolic process; IDA:BHF-UCL.
# GO_process	GO:0043691	reverse cholesterol transport; ISS:BHF-UCL.
# GO_process	GO:0045542	positive regulation of cholesterol biosynthetic process; ISS:BHF-UCL.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GO_process	GO:0055091	phospholipid homeostasis; IMP:BHF-UCL.
# GO_process	GO:0055099	response to high density lipoprotein particle; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008289	lipid binding
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 1.
# Genevisible	P45844	HS
# HGNC	HGNC:73	ABCG1
# INDUCTION	ABCG1_HUMAN	Strongly induced in monocyte-derived macrophages during cholesterol influx. Conversely, mRNA and protein expression are suppressed by lipid efflux. Induction is mediated by the liver X receptor/retinoid X receptor (LXR/RXR) pathway. Not induced by bacterial lipopolysaccharides (LPS). Repressed by ZNF202. {ECO 0000269|PubMed 10639163, ECO 0000269|PubMed 10799558, ECO 0000269|PubMed 11279031, ECO 0000269|PubMed 12032171}. 
# INTERACTION	ABCG1_HUMAN	Q9H172 ABCG4; NbExp=2; IntAct=EBI-8584087, EBI-8584118; 
# IntAct	P45844	5
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR005284	Pigment_permease
# InterPro	IPR013525	ABC_2_trans
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR020064	ABCG1
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko02010	ABC transporters
# MIM	603076	gene
# MISCELLANEOUS	A protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells. {ECO:0000305|PubMed	22042635}. 
# Organism	ABCG1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR19241:SF177	PTHR19241:SF177
# PROSITE	PS00211	ABC_TRANSPORTER_1
# PROSITE	PS50893	ABC_TRANSPORTER_2
# PTM	ABCG1_HUMAN	Palmitoylation at Cys-315 seems important for trafficking from the endoplasmic reticulum. {ECO 0000269|PubMed 23388354}. 
# Pfam	PF00005	ABC_tran
# Pfam	PF01061	ABC2_membrane
# Proteomes	UP000005640	Chromosome 21
# Reactome	R-HSA-1369062	ABC transporters in lipid homeostasis
# Reactome	R-HSA-194223	HDL-mediated lipid transport
# RecName	ABCG1_HUMAN	ATP-binding cassette sub-family G member 1
# RefSeq	NP_004906	NM_004915.3. [P45844-1]
# RefSeq	NP_058198	NM_016818.2. [P45844-4]
# RefSeq	NP_997057	NM_207174.1. [P45844-2]
# RefSeq	NP_997510	NM_207627.1. [P45844-3]
# RefSeq	NP_997511	NM_207628.1. [P45844-7]
# RefSeq	NP_997512	NM_207629.1. [P45844-5]
# SEQUENCE CAUTION	ABCG1_HUMAN	Sequence=AAC51098.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=AAK28841.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=BAA95530.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=BAB13728.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=CAA62631.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=CAC00730.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; 
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 ABC transmembrane type-2 domain. {ECO	0000305}. 
# SIMILARITY	Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA
# SUBCELLULAR LOCATION	ABCG1_HUMAN	Endoplasmic reticulum membrane {ECO 0000269|PubMed 22042635}; Multi-pass membrane protein {ECO 0000269|PubMed 22042635}. Golgi apparatus membrane {ECO 0000269|PubMed 22042635}; Multi-pass membrane protein {ECO 0000269|PubMed 22042635}. Note=Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes. 
# SUBUNIT	ABCG1_HUMAN	May form heterodimers with several heterologous partners of the ABCG subfamily. 
# SUPFAM	SSF52540	SSF52540
# TCDB	3.A.1.204.12	the atp-binding cassette (abc) superfamily
# TIGRFAMs	TIGR00955	3a01204
# TISSUE SPECIFICITY	Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease. {ECO:0000269|PubMed	11350058}. 
# TopDownProteomics	P45844-8	-. [P45844-8]
# UCSC	uc002zan	human. [P45844-1]
# WEB RESOURCE	ABCG1_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=P45844";
# eggNOG	COG1131	LUCA
# eggNOG	KOG0061	Eukaryota
BLAST	swissprot:ABCG1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCG1_HUMAN
BioCyc	ZFISH:ENSG00000160179-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000160179-MONOMER
COXPRESdb	9619	http://coxpresdb.jp/data/gene/9619.shtml
DOI	10.1006/bbrc.2000.4089	http://dx.doi.org/10.1006/bbrc.2000.4089
DOI	10.1006/bbrc.2001.4863	http://dx.doi.org/10.1006/bbrc.2001.4863
DOI	10.1006/geno.2000.6253	http://dx.doi.org/10.1006/geno.2000.6253
DOI	10.1016/S0378-1119(96)00633-6	http://dx.doi.org/10.1016/S0378-1119(96)00633-6
DOI	10.1016/j.bbalip.2013.01.019	http://dx.doi.org/10.1016/j.bbalip.2013.01.019
DOI	10.1038/35012518	http://dx.doi.org/10.1038/35012518
DOI	10.1073/pnas.97.2.817	http://dx.doi.org/10.1073/pnas.97.2.817
DOI	10.1074/jbc.275.19.14700	http://dx.doi.org/10.1074/jbc.275.19.14700
DOI	10.1074/jbc.M100218200	http://dx.doi.org/10.1074/jbc.M100218200
DOI	10.1074/jbc.M105863200	http://dx.doi.org/10.1074/jbc.M105863200
DOI	10.1074/mcp.M111.013458	http://dx.doi.org/10.1074/mcp.M111.013458
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00171	http://www.drugbank.ca/drugs/DB00171
EMBL	AB038161	http://www.ebi.ac.uk/ena/data/view/AB038161
EMBL	AF323640	http://www.ebi.ac.uk/ena/data/view/AF323640
EMBL	AF323642	http://www.ebi.ac.uk/ena/data/view/AF323642
EMBL	AF323643	http://www.ebi.ac.uk/ena/data/view/AF323643
EMBL	AF323644	http://www.ebi.ac.uk/ena/data/view/AF323644
EMBL	AF323645	http://www.ebi.ac.uk/ena/data/view/AF323645
EMBL	AF323645	http://www.ebi.ac.uk/ena/data/view/AF323645
EMBL	AF323645	http://www.ebi.ac.uk/ena/data/view/AF323645
EMBL	AF323645	http://www.ebi.ac.uk/ena/data/view/AF323645
EMBL	AF323645	http://www.ebi.ac.uk/ena/data/view/AF323645
EMBL	AF323646	http://www.ebi.ac.uk/ena/data/view/AF323646
EMBL	AF323646	http://www.ebi.ac.uk/ena/data/view/AF323646
EMBL	AF323646	http://www.ebi.ac.uk/ena/data/view/AF323646
EMBL	AF323646	http://www.ebi.ac.uk/ena/data/view/AF323646
EMBL	AF323646	http://www.ebi.ac.uk/ena/data/view/AF323646
EMBL	AF323647	http://www.ebi.ac.uk/ena/data/view/AF323647
EMBL	AF323647	http://www.ebi.ac.uk/ena/data/view/AF323647
EMBL	AF323647	http://www.ebi.ac.uk/ena/data/view/AF323647
EMBL	AF323647	http://www.ebi.ac.uk/ena/data/view/AF323647
EMBL	AF323647	http://www.ebi.ac.uk/ena/data/view/AF323647
EMBL	AF323648	http://www.ebi.ac.uk/ena/data/view/AF323648
EMBL	AF323648	http://www.ebi.ac.uk/ena/data/view/AF323648
EMBL	AF323648	http://www.ebi.ac.uk/ena/data/view/AF323648
EMBL	AF323648	http://www.ebi.ac.uk/ena/data/view/AF323648
EMBL	AF323648	http://www.ebi.ac.uk/ena/data/view/AF323648
EMBL	AF323649	http://www.ebi.ac.uk/ena/data/view/AF323649
EMBL	AF323649	http://www.ebi.ac.uk/ena/data/view/AF323649
EMBL	AF323649	http://www.ebi.ac.uk/ena/data/view/AF323649
EMBL	AF323649	http://www.ebi.ac.uk/ena/data/view/AF323649
EMBL	AF323649	http://www.ebi.ac.uk/ena/data/view/AF323649
EMBL	AF323650	http://www.ebi.ac.uk/ena/data/view/AF323650
EMBL	AF323650	http://www.ebi.ac.uk/ena/data/view/AF323650
EMBL	AF323650	http://www.ebi.ac.uk/ena/data/view/AF323650
EMBL	AF323650	http://www.ebi.ac.uk/ena/data/view/AF323650
EMBL	AF323650	http://www.ebi.ac.uk/ena/data/view/AF323650
EMBL	AF323651	http://www.ebi.ac.uk/ena/data/view/AF323651
EMBL	AF323651	http://www.ebi.ac.uk/ena/data/view/AF323651
EMBL	AF323651	http://www.ebi.ac.uk/ena/data/view/AF323651
EMBL	AF323651	http://www.ebi.ac.uk/ena/data/view/AF323651
EMBL	AF323651	http://www.ebi.ac.uk/ena/data/view/AF323651
EMBL	AF323652	http://www.ebi.ac.uk/ena/data/view/AF323652
EMBL	AF323652	http://www.ebi.ac.uk/ena/data/view/AF323652
EMBL	AF323652	http://www.ebi.ac.uk/ena/data/view/AF323652
EMBL	AF323652	http://www.ebi.ac.uk/ena/data/view/AF323652
EMBL	AF323652	http://www.ebi.ac.uk/ena/data/view/AF323652
EMBL	AF323653	http://www.ebi.ac.uk/ena/data/view/AF323653
EMBL	AF323653	http://www.ebi.ac.uk/ena/data/view/AF323653
EMBL	AF323653	http://www.ebi.ac.uk/ena/data/view/AF323653
EMBL	AF323653	http://www.ebi.ac.uk/ena/data/view/AF323653
EMBL	AF323653	http://www.ebi.ac.uk/ena/data/view/AF323653
EMBL	AF323654	http://www.ebi.ac.uk/ena/data/view/AF323654
EMBL	AF323654	http://www.ebi.ac.uk/ena/data/view/AF323654
EMBL	AF323654	http://www.ebi.ac.uk/ena/data/view/AF323654
EMBL	AF323654	http://www.ebi.ac.uk/ena/data/view/AF323654
EMBL	AF323654	http://www.ebi.ac.uk/ena/data/view/AF323654
EMBL	AF323655	http://www.ebi.ac.uk/ena/data/view/AF323655
EMBL	AF323655	http://www.ebi.ac.uk/ena/data/view/AF323655
EMBL	AF323655	http://www.ebi.ac.uk/ena/data/view/AF323655
EMBL	AF323655	http://www.ebi.ac.uk/ena/data/view/AF323655
EMBL	AF323655	http://www.ebi.ac.uk/ena/data/view/AF323655
EMBL	AF323656	http://www.ebi.ac.uk/ena/data/view/AF323656
EMBL	AF323656	http://www.ebi.ac.uk/ena/data/view/AF323656
EMBL	AF323656	http://www.ebi.ac.uk/ena/data/view/AF323656
EMBL	AF323656	http://www.ebi.ac.uk/ena/data/view/AF323656
EMBL	AF323656	http://www.ebi.ac.uk/ena/data/view/AF323656
EMBL	AF323657	http://www.ebi.ac.uk/ena/data/view/AF323657
EMBL	AF323657	http://www.ebi.ac.uk/ena/data/view/AF323657
EMBL	AF323657	http://www.ebi.ac.uk/ena/data/view/AF323657
EMBL	AF323657	http://www.ebi.ac.uk/ena/data/view/AF323657
EMBL	AF323657	http://www.ebi.ac.uk/ena/data/view/AF323657
EMBL	AF323658	http://www.ebi.ac.uk/ena/data/view/AF323658
EMBL	AF323658	http://www.ebi.ac.uk/ena/data/view/AF323658
EMBL	AF323658	http://www.ebi.ac.uk/ena/data/view/AF323658
EMBL	AF323658	http://www.ebi.ac.uk/ena/data/view/AF323658
EMBL	AF323658	http://www.ebi.ac.uk/ena/data/view/AF323658
EMBL	AF323660	http://www.ebi.ac.uk/ena/data/view/AF323660
EMBL	AF323661	http://www.ebi.ac.uk/ena/data/view/AF323661
EMBL	AF323662	http://www.ebi.ac.uk/ena/data/view/AF323662
EMBL	AF323663	http://www.ebi.ac.uk/ena/data/view/AF323663
EMBL	AF323664	http://www.ebi.ac.uk/ena/data/view/AF323664
EMBL	AJ289137	http://www.ebi.ac.uk/ena/data/view/AJ289137
EMBL	AJ289138	http://www.ebi.ac.uk/ena/data/view/AJ289138
EMBL	AJ289139	http://www.ebi.ac.uk/ena/data/view/AJ289139
EMBL	AJ289140	http://www.ebi.ac.uk/ena/data/view/AJ289140
EMBL	AJ289141	http://www.ebi.ac.uk/ena/data/view/AJ289141
EMBL	AJ289142	http://www.ebi.ac.uk/ena/data/view/AJ289142
EMBL	AJ289143	http://www.ebi.ac.uk/ena/data/view/AJ289143
EMBL	AJ289144	http://www.ebi.ac.uk/ena/data/view/AJ289144
EMBL	AJ289145	http://www.ebi.ac.uk/ena/data/view/AJ289145
EMBL	AJ289146	http://www.ebi.ac.uk/ena/data/view/AJ289146
EMBL	AJ289147	http://www.ebi.ac.uk/ena/data/view/AJ289147
EMBL	AJ289148	http://www.ebi.ac.uk/ena/data/view/AJ289148
EMBL	AJ289149	http://www.ebi.ac.uk/ena/data/view/AJ289149
EMBL	AJ289150	http://www.ebi.ac.uk/ena/data/view/AJ289150
EMBL	AJ289151	http://www.ebi.ac.uk/ena/data/view/AJ289151
EMBL	AP001746	http://www.ebi.ac.uk/ena/data/view/AP001746
EMBL	AY048757	http://www.ebi.ac.uk/ena/data/view/AY048757
EMBL	BC029158	http://www.ebi.ac.uk/ena/data/view/BC029158
EMBL	U34919	http://www.ebi.ac.uk/ena/data/view/U34919
EMBL	X91249	http://www.ebi.ac.uk/ena/data/view/X91249
Ensembl	ENST00000343687	http://www.ensembl.org/id/ENST00000343687
Ensembl	ENST00000347800	http://www.ensembl.org/id/ENST00000347800
Ensembl	ENST00000361802	http://www.ensembl.org/id/ENST00000361802
Ensembl	ENST00000398449	http://www.ensembl.org/id/ENST00000398449
Ensembl	ENST00000398457	http://www.ensembl.org/id/ENST00000398457
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0009897	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009897
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_component	GO:0055037	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055037
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0005543	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005543
GO_function	GO:0005548	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005548
GO_function	GO:0015485	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015485
GO_function	GO:0017127	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017127
GO_function	GO:0019534	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019534
GO_function	GO:0034041	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034041
GO_function	GO:0034437	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034437
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_function	GO:0043531	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043531
GO_function	GO:0046982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046982
GO_function	GO:0046983	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046983
GO_process	GO:0006355	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355
GO_process	GO:0008203	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008203
GO_process	GO:0009720	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009720
GO_process	GO:0010033	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010033
GO_process	GO:0010745	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010745
GO_process	GO:0010872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010872
GO_process	GO:0010875	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010875
GO_process	GO:0010887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010887
GO_process	GO:0032367	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032367
GO_process	GO:0033344	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033344
GO_process	GO:0033700	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033700
GO_process	GO:0033993	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033993
GO_process	GO:0034374	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034374
GO_process	GO:0034375	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034375
GO_process	GO:0034436	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034436
GO_process	GO:0042157	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042157
GO_process	GO:0042632	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042632
GO_process	GO:0042987	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042987
GO_process	GO:0043691	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043691
GO_process	GO:0045542	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045542
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GO_process	GO:0055091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055091
GO_process	GO:0055099	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055099
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCG1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCG1
GeneID	9619	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9619
GeneTree	ENSGT00740000114855	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00740000114855
HGNC	HGNC:73	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:73
HOVERGEN	HBG103052	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG103052&db=HOVERGEN
HPA	HPA031470	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031470
HPA	HPA031471	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031471
InParanoid	P45844	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45844
IntAct	P45844	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45844*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR005284	http://www.ebi.ac.uk/interpro/entry/IPR005284
InterPro	IPR013525	http://www.ebi.ac.uk/interpro/entry/IPR013525
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR020064	http://www.ebi.ac.uk/interpro/entry/IPR020064
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	9619	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9619
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:9619	http://www.genome.jp/dbget-bin/www_bget?hsa:9619
KEGG_Orthology	KO:K05679	http://www.genome.jp/dbget-bin/www_bget?KO:K05679
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
MIM	603076	http://www.ncbi.nlm.nih.gov/omim/603076
OMA	ASMEGCH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ASMEGCH
PANTHER	PTHR19241:SF177	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19241:SF177
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PSORT	swissprot:ABCG1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCG1_HUMAN
PSORT-B	swissprot:ABCG1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCG1_HUMAN
PSORT2	swissprot:ABCG1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCG1_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF01061	http://pfam.xfam.org/family/PF01061
PharmGKB	PA24408	http://www.pharmgkb.org/do/serve?objId=PA24408&objCls=Gene
Phobius	swissprot:ABCG1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCG1_HUMAN
PhylomeDB	P45844	http://phylomedb.org/?seqid=P45844
ProteinModelPortal	P45844	http://www.proteinmodelportal.org/query/uniprot/P45844
PubMed	10639163	http://www.ncbi.nlm.nih.gov/pubmed/10639163
PubMed	10799558	http://www.ncbi.nlm.nih.gov/pubmed/10799558
PubMed	10830953	http://www.ncbi.nlm.nih.gov/pubmed/10830953
PubMed	10950923	http://www.ncbi.nlm.nih.gov/pubmed/10950923
PubMed	11162488	http://www.ncbi.nlm.nih.gov/pubmed/11162488
PubMed	11279031	http://www.ncbi.nlm.nih.gov/pubmed/11279031
PubMed	11350058	http://www.ncbi.nlm.nih.gov/pubmed/11350058
PubMed	11500512	http://www.ncbi.nlm.nih.gov/pubmed/11500512
PubMed	11590207	http://www.ncbi.nlm.nih.gov/pubmed/11590207
PubMed	12032171	http://www.ncbi.nlm.nih.gov/pubmed/12032171
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	22042635	http://www.ncbi.nlm.nih.gov/pubmed/22042635
PubMed	23388354	http://www.ncbi.nlm.nih.gov/pubmed/23388354
PubMed	8659545	http://www.ncbi.nlm.nih.gov/pubmed/8659545
PubMed	9034316	http://www.ncbi.nlm.nih.gov/pubmed/9034316
Reactome	R-HSA-1369062	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1369062
Reactome	R-HSA-194223	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-194223
RefSeq	NP_004906	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004906
RefSeq	NP_058198	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_058198
RefSeq	NP_997057	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_997057
RefSeq	NP_997510	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_997510
RefSeq	NP_997511	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_997511
RefSeq	NP_997512	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_997512
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	P45844	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45844
STRING	9606.ENSP00000354995	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000354995&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TCDB	3.A.1.204.12	http://www.tcdb.org/search/result.php?tc=3.A.1.204.12
TIGRFAMs	TIGR00955	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00955
UCSC	uc002zan	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002zan&org=rat
UniGene	Hs.124649	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.124649
UniGene	Hs.418279	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.418279
UniProtKB	ABCG1_HUMAN	http://www.uniprot.org/uniprot/ABCG1_HUMAN
UniProtKB-AC	P45844	http://www.uniprot.org/uniprot/P45844
charge	swissprot:ABCG1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCG1_HUMAN
eggNOG	COG1131	http://eggnogapi.embl.de/nog_data/html/tree/COG1131
eggNOG	KOG0061	http://eggnogapi.embl.de/nog_data/html/tree/KOG0061
epestfind	swissprot:ABCG1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCG1_HUMAN
garnier	swissprot:ABCG1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCG1_HUMAN
helixturnhelix	swissprot:ABCG1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCG1_HUMAN
hmoment	swissprot:ABCG1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCG1_HUMAN
iep	swissprot:ABCG1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCG1_HUMAN
inforesidue	swissprot:ABCG1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCG1_HUMAN
neXtProt	NX_P45844	http://www.nextprot.org/db/entry/NX_P45844
octanol	swissprot:ABCG1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCG1_HUMAN
pepcoil	swissprot:ABCG1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCG1_HUMAN
pepdigest	swissprot:ABCG1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCG1_HUMAN
pepinfo	swissprot:ABCG1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCG1_HUMAN
pepnet	swissprot:ABCG1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCG1_HUMAN
pepstats	swissprot:ABCG1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCG1_HUMAN
pepwheel	swissprot:ABCG1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCG1_HUMAN
pepwindow	swissprot:ABCG1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCG1_HUMAN
sigcleave	swissprot:ABCG1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCG1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	COX18_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Hs1; IsoId=Q8N8Q8-1; Sequence=Displayed; Name=2; Synonyms=Hs2; IsoId=Q8N8Q8-2; Sequence=VSP_022312, VSP_022314; Name=3; Synonyms=Hs3; IsoId=Q8N8Q8-3; Sequence=VSP_022311, VSP_022315; Name=4; IsoId=Q8N8Q8-4; Sequence=VSP_022313, VSP_022316; Note=No experimental confirmation available.; 
# AltName	COX18_HUMAN	Cytochrome c oxidase assembly protein 18
# CCDS	CCDS3554	-. [Q8N8Q8-1]
# Ensembl	ENST00000295890	ENSP00000295890; ENSG00000163626. [Q8N8Q8-1]
# Ensembl	ENST00000449739	ENSP00000394583; ENSG00000163626. [Q8N8Q8-3]
# Ensembl	ENST00000510031	ENSP00000424978; ENSG00000163626. [Q8N8Q8-2]
# ExpressionAtlas	Q8N8Q8	baseline and differential
# FUNCTION	COX18_HUMAN	Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c oxidase. Plays a central role in the translocation and export of the C-terminal part of the COX2 protein into the mitochondrial intermembrane space. {ECO 0000269|PubMed 16911509}. 
# GO_component	GO:0031305	integral component of mitochondrial inner membrane; IDA:UniProtKB.
# GO_function	GO:0008565	protein transporter activity; IGI:UniProtKB.
# GO_process	GO:0008535	respiratory chain complex IV assembly; IGI:UniProtKB.
# GO_process	GO:0051204	protein insertion into mitochondrial membrane; IGI:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0007005	mitochondrion organization
# GOslim_process	GO:0061024	membrane organization
# Genevisible	Q8N8Q8	HS
# HGNC	HGNC:26801	COX18
# InterPro	IPR001708	Membrane_insert_OXA1/ALB3/YidC
# MIM	610428	gene
# Organism	COX18_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12428	PTHR12428
# Pfam	PF02096	60KD_IMP
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-5628897	TP53 Regulates Metabolic Genes
# Reactome	R-HSA-611105	Respiratory electron transport
# RecName	COX18_HUMAN	Mitochondrial inner membrane protein COX18
# RefSeq	NP_001284662	NM_001297733.1
# RefSeq	NP_001287658	NM_001300729.1
# RefSeq	NP_776188	NM_173827.3. [Q8N8Q8-1]
# SEQUENCE CAUTION	Sequence=AAH71812.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the OXA1/ALB3/YidC family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	COX18_HUMAN	Mitochondrion inner membrane {ECO 0000269|PubMed 16212937}; Multi-pass membrane protein {ECO 0000269|PubMed 16212937}. 
# UCSC	uc003hgm	human. [Q8N8Q8-1]
# eggNOG	COG0706	LUCA
# eggNOG	KOG1239	Eukaryota
BLAST	swissprot:COX18_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:COX18_HUMAN
BioCyc	ZFISH:ENSG00000163626-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000163626-MONOMER
COXPRESdb	285521	http://coxpresdb.jp/data/gene/285521.shtml
CleanEx	HS_COX18	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_COX18
DOI	10.1016/j.bbrc.2005.09.127	http://dx.doi.org/10.1016/j.bbrc.2005.09.127
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1567-1364.2006.00083.x	http://dx.doi.org/10.1111/j.1567-1364.2006.00083.x
EMBL	AK096310	http://www.ebi.ac.uk/ena/data/view/AK096310
EMBL	AM055750	http://www.ebi.ac.uk/ena/data/view/AM055750
EMBL	AM055751	http://www.ebi.ac.uk/ena/data/view/AM055751
EMBL	AM055752	http://www.ebi.ac.uk/ena/data/view/AM055752
EMBL	AY957564	http://www.ebi.ac.uk/ena/data/view/AY957564
EMBL	AY957565	http://www.ebi.ac.uk/ena/data/view/AY957565
EMBL	BC071812	http://www.ebi.ac.uk/ena/data/view/BC071812
EMBL	BC101684	http://www.ebi.ac.uk/ena/data/view/BC101684
Ensembl	ENST00000295890	http://www.ensembl.org/id/ENST00000295890
Ensembl	ENST00000449739	http://www.ensembl.org/id/ENST00000449739
Ensembl	ENST00000510031	http://www.ensembl.org/id/ENST00000510031
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0031305	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031305
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0008535	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008535
GO_process	GO:0051204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051204
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0007005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007005
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
GeneCards	COX18	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=COX18
GeneID	285521	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=285521
GeneTree	ENSGT00530000063506	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063506
HGNC	HGNC:26801	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:26801
HOVERGEN	HBG081304	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG081304&db=HOVERGEN
HPA	HPA046772	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA046772
HPA	HPA049489	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA049489
InParanoid	Q8N8Q8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8N8Q8
InterPro	IPR001708	http://www.ebi.ac.uk/interpro/entry/IPR001708
Jabion	285521	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=285521
KEGG_Gene	hsa:285521	http://www.genome.jp/dbget-bin/www_bget?hsa:285521
MIM	610428	http://www.ncbi.nlm.nih.gov/omim/610428
PANTHER	PTHR12428	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12428
PSORT	swissprot:COX18_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:COX18_HUMAN
PSORT-B	swissprot:COX18_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:COX18_HUMAN
PSORT2	swissprot:COX18_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:COX18_HUMAN
Pfam	PF02096	http://pfam.xfam.org/family/PF02096
PharmGKB	PA145008543	http://www.pharmgkb.org/do/serve?objId=PA145008543&objCls=Gene
Phobius	swissprot:COX18_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:COX18_HUMAN
PhylomeDB	Q8N8Q8	http://phylomedb.org/?seqid=Q8N8Q8
ProteinModelPortal	Q8N8Q8	http://www.proteinmodelportal.org/query/uniprot/Q8N8Q8
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16212937	http://www.ncbi.nlm.nih.gov/pubmed/16212937
PubMed	16911509	http://www.ncbi.nlm.nih.gov/pubmed/16911509
Reactome	R-HSA-5628897	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5628897
Reactome	R-HSA-611105	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-611105
RefSeq	NP_001284662	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001284662
RefSeq	NP_001287658	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001287658
RefSeq	NP_776188	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_776188
STRING	9606.ENSP00000295890	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000295890&targetmode=cogs
UCSC	uc003hgm	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003hgm&org=rat
UniGene	Hs.356697	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.356697
UniProtKB	COX18_HUMAN	http://www.uniprot.org/uniprot/COX18_HUMAN
UniProtKB-AC	Q8N8Q8	http://www.uniprot.org/uniprot/Q8N8Q8
charge	swissprot:COX18_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:COX18_HUMAN
eggNOG	COG0706	http://eggnogapi.embl.de/nog_data/html/tree/COG0706
eggNOG	KOG1239	http://eggnogapi.embl.de/nog_data/html/tree/KOG1239
epestfind	swissprot:COX18_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:COX18_HUMAN
garnier	swissprot:COX18_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:COX18_HUMAN
helixturnhelix	swissprot:COX18_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:COX18_HUMAN
hmoment	swissprot:COX18_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:COX18_HUMAN
iep	swissprot:COX18_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:COX18_HUMAN
inforesidue	swissprot:COX18_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:COX18_HUMAN
neXtProt	NX_Q8N8Q8	http://www.nextprot.org/db/entry/NX_Q8N8Q8
octanol	swissprot:COX18_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:COX18_HUMAN
pepcoil	swissprot:COX18_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:COX18_HUMAN
pepdigest	swissprot:COX18_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:COX18_HUMAN
pepinfo	swissprot:COX18_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:COX18_HUMAN
pepnet	swissprot:COX18_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:COX18_HUMAN
pepstats	swissprot:COX18_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:COX18_HUMAN
pepwheel	swissprot:COX18_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:COX18_HUMAN
pepwindow	swissprot:COX18_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:COX18_HUMAN
sigcleave	swissprot:COX18_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:COX18_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ATPA_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P25705-1; Sequence=Displayed; Name=2; IsoId=P25705-2; Sequence=VSP_045129; Name=3; IsoId=P25705-3; Sequence=VSP_054688; Note=No experimental confirmation available.; 
# BioGrid	106987	167
# CCDS	CCDS11927	-. [P25705-1]
# CCDS	CCDS58620	-. [P25705-2]
# CCDS	CCDS59315	-. [P25705-3]
# CDD	cd01132	F1_ATPase_alpha
# ChiTaRS	ATP5A1	human
# DISEASE	ATPA_HUMAN	Combined oxidative phosphorylation deficiency 22 (COXPD22) [MIM 616045]  A mitochondrial disorder characterized by intrauterine growth retardation, microcephaly, hypotonia, pulmonary hypertension, failure to thrive, encephalopathy, and heart failure. {ECO 0000269|PubMed 23596069}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ATPA_HUMAN	Mitochondrial complex V deficiency, nuclear 4 (MC5DN4) [MIM 615228]  A mitochondrial disorder with heterogeneous clinical manifestations including dysmorphic features, psychomotor retardation, hypotonia, growth retardation, cardiomyopathy, enlarged liver, hypoplastic kidneys and elevated lactate levels in urine, plasma and cerebrospinal fluid. {ECO 0000269|PubMed 23599390}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000282050	ENSP00000282050; ENSG00000152234. [P25705-1]
# Ensembl	ENST00000398752	ENSP00000381736; ENSG00000152234. [P25705-1]
# Ensembl	ENST00000590665	ENSP00000467037; ENSG00000152234. [P25705-3]
# Ensembl	ENST00000593152	ENSP00000465477; ENSG00000152234. [P25705-2]
# ExpressionAtlas	P25705	baseline and differential
# FUNCTION	ATPA_HUMAN	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity). {ECO 0000250, ECO 0000269|PubMed 10077593, ECO 0000269|PubMed 19285951}. 
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; IDA:UniProtKB.
# GO_component	GO:0005753	mitochondrial proton-transporting ATP synthase complex; IDA:UniProtKB.
# GO_component	GO:0005759	mitochondrial matrix; TAS:Reactome.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0031012	extracellular matrix; IDA:BHF-UCL.
# GO_component	GO:0043209	myelin sheath; IEA:Ensembl.
# GO_component	GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1); IEA:UniProtKB-KW.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005524	ATP binding; ISS:UniProtKB.
# GO_function	GO:0022857	transmembrane transporter activity; IC:UniProtKB.
# GO_function	GO:0042288	MHC class I protein binding; IDA:UniProtKB.
# GO_function	GO:0044822	poly(A) RNA binding; IDA:UniProtKB.
# GO_function	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism; ISS:UniProtKB.
# GO_process	GO:0001937	negative regulation of endothelial cell proliferation; IMP:UniProtKB.
# GO_process	GO:0006629	lipid metabolic process; ISS:UniProtKB.
# GO_process	GO:0006754	ATP biosynthetic process; NAS:UniProtKB.
# GO_process	GO:0009790	embryo development; ISS:UniProtKB.
# GO_process	GO:0042776	mitochondrial ATP synthesis coupled proton transport; IC:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0003723	RNA binding
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0009790	embryo development
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.40.30.20	-; 1.
# Gene3D	3.40.50.300	-; 1.
# Genevisible	P25705	HS
# HAMAP	MF_01346	ATP_synth_alpha_bact
# HGNC	HGNC:823	ATP5A1
# INTERACTION	ATPA_HUMAN	P78537 BLOC1S1; NbExp=2; IntAct=EBI-351437, EBI-348630; Q9NTG7 SIRT3; NbExp=2; IntAct=EBI-351437, EBI-724621; P63104 YWHAZ; NbExp=3; IntAct=EBI-351437, EBI-347088; 
# IntAct	P25705	61
# InterPro	IPR000194	ATPase_F1/V1/A1_a/bsu_nucl-bd
# InterPro	IPR000793	ATP_synth_asu_C
# InterPro	IPR004100	ATPase_F1/V1/A1_a/bsu_N
# InterPro	IPR005294	ATP_synth_F1_asu
# InterPro	IPR020003	ATPase_a/bsu_AS
# InterPro	IPR023366	ATP_synth_asu-like
# InterPro	IPR027417	P-loop_NTPase
# InterPro	IPR033732	ATP_synth_F1_a
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Disease	H01369	[Inherited metabolic disease; Mitochondrial disease] Mitochondrial infantile bilateral striatal necrosis (MIBSN)
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	164360	gene
# MIM	615228	phenotype
# MIM	616045	phenotype
# Organism	ATPA_HUMAN	Homo sapiens (Human)
# Orphanet	254913	Isolated ATP synthase deficiency
# PANTHER	PTHR15184:SF3	PTHR15184:SF3
# PIR	S17193	PWHUA
# PIRSF	PIRSF039088	F_ATPase_subunit_alpha
# PROSITE	PS00152	ATPASE_ALPHA_BETA
# PTM	ATPA_HUMAN	Acetylated on lysine residues. BLOC1S1 is required for acetylation. {ECO 0000269|PubMed 22309213}. 
# PTM	ATPA_HUMAN	The N-terminus is blocked. 
# Pfam	PF00006	ATP-synt_ab
# Pfam	PF00306	ATP-synt_ab_C
# Pfam	PF02874	ATP-synt_ab_N
# Proteomes	UP000005640	Chromosome 18
# Reactome	R-HSA-1268020	Mitochondrial protein import
# Reactome	R-HSA-163210	Formation of ATP by chemiosmotic coupling
# RecName	ATPA_HUMAN	ATP synthase subunit alpha, mitochondrial
# RefSeq	NP_001001935	NM_001001935.2. [P25705-2]
# RefSeq	NP_001001937	NM_001001937.1. [P25705-1]
# RefSeq	NP_001244263	NM_001257334.1. [P25705-3]
# RefSeq	NP_001244264	NM_001257335.1. [P25705-2]
# RefSeq	NP_004037	NM_004046.5. [P25705-1]
# SIMILARITY	Belongs to the ATPase alpha/beta chains family. {ECO	0000305}.
# SUBCELLULAR LOCATION	ATPA_HUMAN	Mitochondrion inner membrane {ECO 0000305}. Cell membrane; Peripheral membrane protein; Extracellular side {ECO 0000269|PubMed 10077593}. Note=Colocalizes with HRG on the cell surface of T-cells (PubMed 19285951). 
# SUBUNIT	ATPA_HUMAN	F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits  alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits  a, b and c. Interacts with ATPAF2 (PubMed 11410595). Interacts with HRG; the interaction occurs on the surface of T-cells and alters the cell morphology when associated with concanavalin (in vitro) (PubMed 19285951). Interacts with PLG (angiostatin peptide); the interaction inhibits most of the angiogenic properties of angiostatin (PubMed 10077593). Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68. Interacts with BLOC1S1 (PubMed 22309213). Interacts with BCL2L1 isoform BCL-X(L); the interaction mediates the association of BCL2L1 isoform BCL-X(L) with the mitochondrial membrane F(1)F(0) ATP synthase and enhances neurons metabolic efficency. Interacts with CLN5 and PPT1 (By similarity). {ECO 0000250|UniProtKB Q03265, ECO 0000269|PubMed 10077593, ECO 0000269|PubMed 11410595, ECO 0000269|PubMed 19285951, ECO 0000269|PubMed 22309213}. 
# SUPFAM	SSF50615	SSF50615
# SUPFAM	SSF52540	SSF52540
# TIGRFAMs	TIGR00962	atpA
# TISSUE SPECIFICITY	Fetal lung, heart, liver, gut and kidney. Expressed at higher levels in the fetal brain, retina and spinal cord. {ECO:0000269|PubMed	8428659}. 
# TopDownProteomics	P25705-1	-. [P25705-1]
# UCSC	uc010dnl	human. [P25705-1]
# eggNOG	COG0056	LUCA
# eggNOG	KOG1353	Eukaryota
BLAST	swissprot:ATPA_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ATPA_HUMAN
BioCyc	ZFISH:HS07800-MONOMER	http://biocyc.org/getid?id=ZFISH:HS07800-MONOMER
COG	COG0056	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0056
COXPRESdb	498	http://coxpresdb.jp/data/gene/498.shtml
CleanEx	HS_ATP5A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP5A1
DIP	DIP-32871N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-32871N
DOI	10.1002/elps.11501601192	http://dx.doi.org/10.1002/elps.11501601192
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/0167-4781(91)90183-M	http://dx.doi.org/10.1016/0167-4781(91)90183-M
DOI	10.1016/0167-4781(94)90255-0	http://dx.doi.org/10.1016/0167-4781(94)90255-0
DOI	10.1016/0378-1119(93)90124-L	http://dx.doi.org/10.1016/0378-1119(93)90124-L
DOI	10.1016/j.bbamem.2009.03.005	http://dx.doi.org/10.1016/j.bbamem.2009.03.005
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature03983	http://dx.doi.org/10.1038/nature03983
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/BJ20120118	http://dx.doi.org/10.1042/BJ20120118
DOI	10.1073/pnas.0908958106	http://dx.doi.org/10.1073/pnas.0908958106
DOI	10.1073/pnas.96.6.2811	http://dx.doi.org/10.1073/pnas.96.6.2811
DOI	10.1074/jbc.M104133200	http://dx.doi.org/10.1074/jbc.M104133200
DOI	10.1093/brain/awt086	http://dx.doi.org/10.1093/brain/awt086
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1212/WNL.0b013e3182918c40	http://dx.doi.org/10.1212/WNL.0b013e3182918c40
EMBL	AC012569	http://www.ebi.ac.uk/ena/data/view/AC012569
EMBL	AK092735	http://www.ebi.ac.uk/ena/data/view/AK092735
EMBL	AK289457	http://www.ebi.ac.uk/ena/data/view/AK289457
EMBL	AK302272	http://www.ebi.ac.uk/ena/data/view/AK302272
EMBL	BC003119	http://www.ebi.ac.uk/ena/data/view/BC003119
EMBL	BC007299	http://www.ebi.ac.uk/ena/data/view/BC007299
EMBL	BC008028	http://www.ebi.ac.uk/ena/data/view/BC008028
EMBL	BC011384	http://www.ebi.ac.uk/ena/data/view/BC011384
EMBL	BC016046	http://www.ebi.ac.uk/ena/data/view/BC016046
EMBL	BC019310	http://www.ebi.ac.uk/ena/data/view/BC019310
EMBL	BC039135	http://www.ebi.ac.uk/ena/data/view/BC039135
EMBL	BC064562	http://www.ebi.ac.uk/ena/data/view/BC064562
EMBL	BC067385	http://www.ebi.ac.uk/ena/data/view/BC067385
EMBL	BT007209	http://www.ebi.ac.uk/ena/data/view/BT007209
EMBL	D14710	http://www.ebi.ac.uk/ena/data/view/D14710
EMBL	D28126	http://www.ebi.ac.uk/ena/data/view/D28126
EMBL	X59066	http://www.ebi.ac.uk/ena/data/view/X59066
EMBL	X65460	http://www.ebi.ac.uk/ena/data/view/X65460
Ensembl	ENST00000282050	http://www.ensembl.org/id/ENST00000282050
Ensembl	ENST00000398752	http://www.ensembl.org/id/ENST00000398752
Ensembl	ENST00000590665	http://www.ensembl.org/id/ENST00000590665
Ensembl	ENST00000593152	http://www.ensembl.org/id/ENST00000593152
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005753	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005753
GO_component	GO:0005759	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005759
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0031012	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031012
GO_component	GO:0043209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043209
GO_component	GO:0045261	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045261
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GO_function	GO:0042288	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042288
GO_function	GO:0044822	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044822
GO_function	GO:0046933	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046933
GO_process	GO:0001937	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001937
GO_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GO_process	GO:0006754	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006754
GO_process	GO:0009790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009790
GO_process	GO:0042776	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042776
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0003723	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0009790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009790
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.40.30.20	http://www.cathdb.info/version/latest/superfamily/2.40.30.20
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ATP5A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP5A1
GeneID	498	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=498
GeneTree	ENSGT00550000074846	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074846
HAMAP	MF_01346	http://hamap.expasy.org/unirule/MF_01346
HGNC	HGNC:823	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:823
HOVERGEN	HBG001536	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG001536&db=HOVERGEN
HPA	CAB013067	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB013067
HPA	HPA040622	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA040622
HPA	HPA044202	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA044202
InParanoid	P25705	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25705
IntAct	P25705	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25705*
InterPro	IPR000194	http://www.ebi.ac.uk/interpro/entry/IPR000194
InterPro	IPR000793	http://www.ebi.ac.uk/interpro/entry/IPR000793
InterPro	IPR004100	http://www.ebi.ac.uk/interpro/entry/IPR004100
InterPro	IPR005294	http://www.ebi.ac.uk/interpro/entry/IPR005294
InterPro	IPR020003	http://www.ebi.ac.uk/interpro/entry/IPR020003
InterPro	IPR023366	http://www.ebi.ac.uk/interpro/entry/IPR023366
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
InterPro	IPR033732	http://www.ebi.ac.uk/interpro/entry/IPR033732
Jabion	498	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=498
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Disease	H01369	http://www.genome.jp/dbget-bin/www_bget?H01369
KEGG_Gene	hsa:498	http://www.genome.jp/dbget-bin/www_bget?hsa:498
KEGG_Orthology	KO:K02132	http://www.genome.jp/dbget-bin/www_bget?KO:K02132
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	164360	http://www.ncbi.nlm.nih.gov/omim/164360
MIM	615228	http://www.ncbi.nlm.nih.gov/omim/615228
MIM	616045	http://www.ncbi.nlm.nih.gov/omim/616045
MINT	MINT-1163289	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1163289
OMA	KRFNEAQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KRFNEAQ
Orphanet	254913	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=254913
OrthoDB	EOG091G0D1M	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0D1M
PANTHER	PTHR15184:SF3	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15184:SF3
PROSITE	PS00152	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00152
PSORT	swissprot:ATPA_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ATPA_HUMAN
PSORT-B	swissprot:ATPA_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ATPA_HUMAN
PSORT2	swissprot:ATPA_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ATPA_HUMAN
Pfam	PF00006	http://pfam.xfam.org/family/PF00006
Pfam	PF00306	http://pfam.xfam.org/family/PF00306
Pfam	PF02874	http://pfam.xfam.org/family/PF02874
PharmGKB	PA25115	http://www.pharmgkb.org/do/serve?objId=PA25115&objCls=Gene
Phobius	swissprot:ATPA_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ATPA_HUMAN
PhylomeDB	P25705	http://phylomedb.org/?seqid=P25705
ProteinModelPortal	P25705	http://www.proteinmodelportal.org/query/uniprot/P25705
PubMed	10077593	http://www.ncbi.nlm.nih.gov/pubmed/10077593
PubMed	11410595	http://www.ncbi.nlm.nih.gov/pubmed/11410595
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16177791	http://www.ncbi.nlm.nih.gov/pubmed/16177791
PubMed	1830491	http://www.ncbi.nlm.nih.gov/pubmed/1830491
PubMed	19285951	http://www.ncbi.nlm.nih.gov/pubmed/19285951
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	19892738	http://www.ncbi.nlm.nih.gov/pubmed/19892738
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	22309213	http://www.ncbi.nlm.nih.gov/pubmed/22309213
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	23596069	http://www.ncbi.nlm.nih.gov/pubmed/23596069
PubMed	23599390	http://www.ncbi.nlm.nih.gov/pubmed/23599390
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	7498159	http://www.ncbi.nlm.nih.gov/pubmed/7498159
PubMed	8086450	http://www.ncbi.nlm.nih.gov/pubmed/8086450
PubMed	8428659	http://www.ncbi.nlm.nih.gov/pubmed/8428659
Reactome	R-HSA-1268020	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1268020
Reactome	R-HSA-163210	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-163210
RefSeq	NP_001001935	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001001935
RefSeq	NP_001001937	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001001937
RefSeq	NP_001244263	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001244263
RefSeq	NP_001244264	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001244264
RefSeq	NP_004037	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004037
SMR	P25705	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P25705
STRING	9606.ENSP00000282050	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000282050&targetmode=cogs
STRING	COG0056	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0056&targetmode=cogs
SUPFAM	SSF50615	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50615
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TIGRFAMs	TIGR00962	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00962
UCSC	uc010dnl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010dnl&org=rat
UniGene	Hs.298280	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.298280
UniProtKB	ATPA_HUMAN	http://www.uniprot.org/uniprot/ATPA_HUMAN
UniProtKB-AC	P25705	http://www.uniprot.org/uniprot/P25705
charge	swissprot:ATPA_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ATPA_HUMAN
eggNOG	COG0056	http://eggnogapi.embl.de/nog_data/html/tree/COG0056
eggNOG	KOG1353	http://eggnogapi.embl.de/nog_data/html/tree/KOG1353
epestfind	swissprot:ATPA_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ATPA_HUMAN
garnier	swissprot:ATPA_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ATPA_HUMAN
helixturnhelix	swissprot:ATPA_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATPA_HUMAN
hmoment	swissprot:ATPA_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ATPA_HUMAN
iep	swissprot:ATPA_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ATPA_HUMAN
inforesidue	swissprot:ATPA_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ATPA_HUMAN
neXtProt	NX_P25705	http://www.nextprot.org/db/entry/NX_P25705
octanol	swissprot:ATPA_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ATPA_HUMAN
pepcoil	swissprot:ATPA_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ATPA_HUMAN
pepdigest	swissprot:ATPA_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ATPA_HUMAN
pepinfo	swissprot:ATPA_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ATPA_HUMAN
pepnet	swissprot:ATPA_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ATPA_HUMAN
pepstats	swissprot:ATPA_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ATPA_HUMAN
pepwheel	swissprot:ATPA_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ATPA_HUMAN
pepwindow	swissprot:ATPA_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ATPA_HUMAN
sigcleave	swissprot:ATPA_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ATPA_HUMAN
## Database	ID	URL or Descriptions
# AltName	VDAC1_HUMAN	Outer mitochondrial membrane protein porin 1
# AltName	VDAC1_HUMAN	Plasmalemmal porin
# AltName	VDAC1_HUMAN	Porin 31HL
# AltName	VDAC1_HUMAN	Porin 31HM
# BioGrid	113259	135
# ChiTaRS	VDAC1	human
# DOMAIN	VDAC1_HUMAN	Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity. 
# DrugBank	DB01375	Dihydroxyaluminium
# ENZYME REGULATION	Inhibited by nitric oxide. {ECO:0000269|PubMed	21156174}. 
# Ensembl	ENST00000265333	ENSP00000265333; ENSG00000213585
# Ensembl	ENST00000395044	ENSP00000378484; ENSG00000213585
# Ensembl	ENST00000395047	ENSP00000378487; ENSG00000213585
# ExpressionAtlas	P21796	baseline and differential
# FUNCTION	VDAC1_HUMAN	Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed 11845315, PubMed 18755977, PubMed 20230784, PubMed 8420959). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed 15033708, PubMed 25296756). {ECO 0000269|PubMed 11845315, ECO 0000269|PubMed 15033708, ECO 0000269|PubMed 18755977, ECO 0000269|PubMed 20230784, ECO 0000269|PubMed 25296756, ECO 0000269|PubMed 8420959}. 
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005741	mitochondrial outer membrane; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0008021	synaptic vesicle; IEA:Ensembl.
# GO_component	GO:0016020	membrane; ISS:UniProtKB.
# GO_component	GO:0042645	mitochondrial nucleoid; IDA:BHF-UCL.
# GO_component	GO:0043209	myelin sheath; IEA:Ensembl.
# GO_component	GO:0045121	membrane raft; IEA:UniProtKB-SubCell.
# GO_component	GO:0046930	pore complex; TAS:HGNC.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0008308	voltage-gated anion channel activity; IDA:UniProtKB.
# GO_function	GO:0015288	porin activity; IEA:UniProtKB-KW.
# GO_function	GO:0019901	protein kinase binding; IPI:ParkinsonsUK-UCL.
# GO_function	GO:0044325	ion channel binding; IPI:UniProtKB.
# GO_process	GO:0001662	behavioral fear response; IEA:Ensembl.
# GO_process	GO:0006820	anion transport; IDA:UniProtKB.
# GO_process	GO:0006851	mitochondrial calcium ion transport; IEA:Ensembl.
# GO_process	GO:0006915	apoptotic process; IDA:UniProtKB.
# GO_process	GO:0007270	neuron-neuron synaptic transmission; IEA:Ensembl.
# GO_process	GO:0007612	learning; IEA:Ensembl.
# GO_process	GO:0016032	viral process; IEA:UniProtKB-KW.
# GO_process	GO:0016236	macroautophagy; TAS:Reactome.
# GO_process	GO:0030855	epithelial cell differentiation; IEP:UniProtKB.
# GO_process	GO:1903146	regulation of mitophagy; NAS:ParkinsonsUK-UCL.
# GO_process	GO:2000378	negative regulation of reactive oxygen species metabolic process; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006914	autophagy
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0008219	cell death
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# GOslim_process	GO:0050877	neurological system process
# Gene3D	2.40.160.10	-; 1.
# Genevisible	P21796	HS
# HGNC	HGNC:12669	VDAC1
# INTERACTION	VDAC1_HUMAN	Q7L3V2 BOP; NbExp=2; IntAct=EBI-354158, EBI-10697720; P19367 HK1; NbExp=2; IntAct=EBI-354158, EBI-713162; Q14643 ITPR1; NbExp=3; IntAct=EBI-354158, EBI-465548; 
# IntAct	P21796	45
# InterPro	IPR001925	Porin_Euk
# InterPro	IPR023614	Porin_dom
# InterPro	IPR027246	Porin_Euk/Tom40
# InterPro	IPR030270	VDAC1
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# KEGG_Pathway	ko05164	Influenza A
# KEGG_Pathway	ko05166	HTLV-I infection
# MIM	604492	gene+phenotype
# Organism	VDAC1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11743:SF13	PTHR11743:SF13
# PDB	2JK4	X-ray; 4.10 A; A=2-283
# PDB	2K4T	NMR; -; A=1-283
# PDB	5JDP	NMR; -; A=2-283
# PIR	A44422	MMHUP3
# PRINTS	PR00185	EUKARYTPORIN
# PROSITE	PS00558	EUKARYOTIC_PORIN
# PTM	VDAC1_HUMAN	Phosphorylation at Ser-193 by NEK1 promotes the open conformational state preventing excessive mitochondrial membrane permeability and subsequent apoptotic cell death after injury. Phosphorylation by the AKT-GSK3B axis stabilizes the protein probably by preventing ubiquitin-mediated proteasomal degradation. {ECO 0000269|PubMed 20230784}. 
# PTM	VDAC1_HUMAN	Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. {ECO 0000269|PubMed 25621951}. 
# Pfam	PF01459	Porin_3
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-1268020	Mitochondrial protein import
# Reactome	R-HSA-5205685	Pink/Parkin Mediated Mitophagy
# Reactome	R-HSA-5689880	Ub-specific processing proteases
# RecName	VDAC1_HUMAN	Voltage-dependent anion-selective channel protein 1
# RefSeq	NP_003365	NM_003374.2
# RefSeq	XP_005272132	XM_005272075.3
# RefSeq	XP_016865310	XM_017009821.1
# RefSeq	XP_016865311	XM_017009822.1
# RefSeq	XP_016865312	XM_017009823.1
# SIMILARITY	Belongs to the eukaryotic mitochondrial porin family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	VDAC1_HUMAN	Mitochondrion outer membrane {ECO 0000269|PubMed 7539795}; Multi-pass membrane protein {ECO 0000269|PubMed 18755977, ECO 0000269|PubMed 18832158}. Cell membrane {ECO 0000269|PubMed 25168729, ECO 0000269|PubMed 25296756}; Multi-pass membrane protein {ECO 0000269|PubMed 18755977, ECO 0000269|PubMed 18832158}. Membrane raft {ECO 0000269|PubMed 25168729}; Multi-pass membrane protein {ECO 0000269|PubMed 18755977, ECO 0000269|PubMed 18832158}. 
# SUBUNIT	(Microbial infection) Interacts with influenza A virus PB1-F2 protein. {ECO:0000269|PubMed	16201016}. 
# SUBUNIT	VDAC1_HUMAN	Interacts with hexokinases including HK1 (PubMed 8420959, PubMed 22304920). The HK1-VDAC1 complex interacts with ATF2 (PubMed 22304920). Interacts with BCL2L1 (PubMed 18755977, PubMed 25296756). Interacts with BAK1 (PubMed 25296756). Interacts with BOP/C22orf29 (via BH3 domain) (PubMed 23055042). Interacts with beta amyloid and APP; induces VDAC1 dephosphorylation (PubMed 25168729). {ECO 0000269|PubMed 18755977, ECO 0000269|PubMed 22304920, ECO 0000269|PubMed 23055042, ECO 0000269|PubMed 25168729, ECO 0000269|PubMed 25296756, ECO 0000269|PubMed 8420959}. 
# TISSUE SPECIFICITY	VDAC1_HUMAN	Heart, liver and skeletal muscle. 
# UCSC	uc003kyp	human
# WEB RESOURCE	VDAC1_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/VDAC1ID50902ch5q31.html";
# eggNOG	ENOG410ZBK1	LUCA
# eggNOG	KOG3126	Eukaryota
BLAST	swissprot:VDAC1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VDAC1_HUMAN
BioCyc	ZFISH:ENSG00000073905-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000073905-MONOMER
COXPRESdb	7416	http://coxpresdb.jp/data/gene/7416.shtml
CleanEx	HS_VDAC1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_VDAC1
DIP	DIP-32862N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-32862N
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/bbrc.2000.2487	http://dx.doi.org/10.1006/bbrc.2000.2487
DOI	10.1007/s003359901158	http://dx.doi.org/10.1007/s003359901158
DOI	10.1007/s004240100656	http://dx.doi.org/10.1007/s004240100656
DOI	10.1007/s13238-012-2069-7	http://dx.doi.org/10.1007/s13238-012-2069-7
DOI	10.1016/j.bbrc.2010.03.077	http://dx.doi.org/10.1016/j.bbrc.2010.03.077
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.cell.2012.01.016	http://dx.doi.org/10.1016/j.cell.2012.01.016
DOI	10.1016/j.febslet.2010.12.008	http://dx.doi.org/10.1016/j.febslet.2010.12.008
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1016/j.neuroscience.2014.07.079	http://dx.doi.org/10.1016/j.neuroscience.2014.07.079
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr0704130	http://dx.doi.org/10.1021/pr0704130
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1038/ncb3097	http://dx.doi.org/10.1038/ncb3097
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.0808115105	http://dx.doi.org/10.1073/pnas.0808115105
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1073/pnas.90.12.5446	http://dx.doi.org/10.1073/pnas.90.12.5446
DOI	10.1074/jbc.270.23.13998	http://dx.doi.org/10.1074/jbc.270.23.13998
DOI	10.1074/jbc.M114.567792	http://dx.doi.org/10.1074/jbc.M114.567792
DOI	10.1074/mcp.M111.015131	http://dx.doi.org/10.1074/mcp.M111.015131
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1161302	http://dx.doi.org/10.1126/science.1161302
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1196/annals.1299.022	http://dx.doi.org/10.1196/annals.1299.022
DOI	10.1371/journal.ppat.0010004	http://dx.doi.org/10.1371/journal.ppat.0010004
DOI	10.1515/BC.1999.189	http://dx.doi.org/10.1515/BC.1999.189
DrugBank	DB01375	http://www.drugbank.ca/drugs/DB01375
EMBL	AC005200	http://www.ebi.ac.uk/ena/data/view/AC005200
EMBL	AC008608	http://www.ebi.ac.uk/ena/data/view/AC008608
EMBL	AF151093	http://www.ebi.ac.uk/ena/data/view/AF151093
EMBL	AF151094	http://www.ebi.ac.uk/ena/data/view/AF151094
EMBL	AF151095	http://www.ebi.ac.uk/ena/data/view/AF151095
EMBL	AF151096	http://www.ebi.ac.uk/ena/data/view/AF151096
EMBL	AF151097	http://www.ebi.ac.uk/ena/data/view/AF151097
EMBL	AJ250032	http://www.ebi.ac.uk/ena/data/view/AJ250032
EMBL	AJ250033	http://www.ebi.ac.uk/ena/data/view/AJ250033
EMBL	AJ250034	http://www.ebi.ac.uk/ena/data/view/AJ250034
EMBL	AJ250035	http://www.ebi.ac.uk/ena/data/view/AJ250035
EMBL	AJ250036	http://www.ebi.ac.uk/ena/data/view/AJ250036
EMBL	AJ250037	http://www.ebi.ac.uk/ena/data/view/AJ250037
EMBL	AJ250038	http://www.ebi.ac.uk/ena/data/view/AJ250038
EMBL	AJ250039	http://www.ebi.ac.uk/ena/data/view/AJ250039
EMBL	AK122953	http://www.ebi.ac.uk/ena/data/view/AK122953
EMBL	BC008482	http://www.ebi.ac.uk/ena/data/view/BC008482
EMBL	BC071168	http://www.ebi.ac.uk/ena/data/view/BC071168
EMBL	BC090042	http://www.ebi.ac.uk/ena/data/view/BC090042
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	L06132	http://www.ebi.ac.uk/ena/data/view/L06132
Ensembl	ENST00000265333	http://www.ensembl.org/id/ENST00000265333
Ensembl	ENST00000395044	http://www.ensembl.org/id/ENST00000395044
Ensembl	ENST00000395047	http://www.ensembl.org/id/ENST00000395047
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005741	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005741
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008021
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0042645	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042645
GO_component	GO:0043209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043209
GO_component	GO:0045121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045121
GO_component	GO:0046930	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046930
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0008308	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008308
GO_function	GO:0015288	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015288
GO_function	GO:0019901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019901
GO_function	GO:0044325	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044325
GO_process	GO:0001662	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001662
GO_process	GO:0006820	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006820
GO_process	GO:0006851	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006851
GO_process	GO:0006915	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006915
GO_process	GO:0007270	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007270
GO_process	GO:0007612	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007612
GO_process	GO:0016032	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016032
GO_process	GO:0016236	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016236
GO_process	GO:0030855	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030855
GO_process	GO:1903146	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903146
GO_process	GO:2000378	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000378
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006914	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006914
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0008219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
Gene3D	2.40.160.10	http://www.cathdb.info/version/latest/superfamily/2.40.160.10
GeneCards	VDAC1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=VDAC1
GeneID	7416	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7416
GeneTree	ENSGT00390000011336	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000011336
H-InvDB	HIX0056260	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0056260
HGNC	HGNC:12669	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:12669
HOGENOM	HOG000188277	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000188277&db=HOGENOM6
HOVERGEN	HBG054036	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054036&db=HOVERGEN
HPA	CAB005885	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB005885
HPA	HPA030780	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA030780
InParanoid	P21796	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21796
IntAct	P21796	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21796*
InterPro	IPR001925	http://www.ebi.ac.uk/interpro/entry/IPR001925
InterPro	IPR023614	http://www.ebi.ac.uk/interpro/entry/IPR023614
InterPro	IPR027246	http://www.ebi.ac.uk/interpro/entry/IPR027246
InterPro	IPR030270	http://www.ebi.ac.uk/interpro/entry/IPR030270
Jabion	7416	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7416
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:7416	http://www.genome.jp/dbget-bin/www_bget?hsa:7416
KEGG_Orthology	KO:K05862	http://www.genome.jp/dbget-bin/www_bget?KO:K05862
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
KEGG_Pathway	ko05164	http://www.genome.jp/kegg-bin/show_pathway?ko05164
KEGG_Pathway	ko05166	http://www.genome.jp/kegg-bin/show_pathway?ko05166
MIM	604492	http://www.ncbi.nlm.nih.gov/omim/604492
MINT	MINT-5002499	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5002499
OMA	YGLMFTE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YGLMFTE
OrthoDB	EOG091G0F0O	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0F0O
PANTHER	PTHR11743:SF13	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11743:SF13
PDB	2JK4	http://www.ebi.ac.uk/pdbe-srv/view/entry/2JK4
PDB	2K4T	http://www.ebi.ac.uk/pdbe-srv/view/entry/2K4T
PDB	5JDP	http://www.ebi.ac.uk/pdbe-srv/view/entry/5JDP
PDBsum	2JK4	http://www.ebi.ac.uk/pdbsum/2JK4
PDBsum	2K4T	http://www.ebi.ac.uk/pdbsum/2K4T
PDBsum	5JDP	http://www.ebi.ac.uk/pdbsum/5JDP
PRINTS	PR00185	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00185
PROSITE	PS00558	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00558
PSORT	swissprot:VDAC1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VDAC1_HUMAN
PSORT-B	swissprot:VDAC1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VDAC1_HUMAN
PSORT2	swissprot:VDAC1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VDAC1_HUMAN
Pfam	PF01459	http://pfam.xfam.org/family/PF01459
PharmGKB	PA37292	http://www.pharmgkb.org/do/serve?objId=PA37292&objCls=Gene
Phobius	swissprot:VDAC1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VDAC1_HUMAN
PhylomeDB	P21796	http://phylomedb.org/?seqid=P21796
ProteinModelPortal	P21796	http://www.proteinmodelportal.org/query/uniprot/P21796
PubMed	10501981	http://www.ncbi.nlm.nih.gov/pubmed/10501981
PubMed	10661876	http://www.ncbi.nlm.nih.gov/pubmed/10661876
PubMed	10772903	http://www.ncbi.nlm.nih.gov/pubmed/10772903
PubMed	11845315	http://www.ncbi.nlm.nih.gov/pubmed/11845315
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15033708	http://www.ncbi.nlm.nih.gov/pubmed/15033708
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16201016	http://www.ncbi.nlm.nih.gov/pubmed/16201016
PubMed	1657034	http://www.ncbi.nlm.nih.gov/pubmed/1657034
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	18088087	http://www.ncbi.nlm.nih.gov/pubmed/18088087
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	18755977	http://www.ncbi.nlm.nih.gov/pubmed/18755977
PubMed	18832158	http://www.ncbi.nlm.nih.gov/pubmed/18832158
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	20230784	http://www.ncbi.nlm.nih.gov/pubmed/20230784
PubMed	21156174	http://www.ncbi.nlm.nih.gov/pubmed/21156174
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	22223895	http://www.ncbi.nlm.nih.gov/pubmed/22223895
PubMed	22304920	http://www.ncbi.nlm.nih.gov/pubmed/22304920
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23055042	http://www.ncbi.nlm.nih.gov/pubmed/23055042
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25168729	http://www.ncbi.nlm.nih.gov/pubmed/25168729
PubMed	25296756	http://www.ncbi.nlm.nih.gov/pubmed/25296756
PubMed	2559745	http://www.ncbi.nlm.nih.gov/pubmed/2559745
PubMed	25621951	http://www.ncbi.nlm.nih.gov/pubmed/25621951
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	7539795	http://www.ncbi.nlm.nih.gov/pubmed/7539795
PubMed	7685903	http://www.ncbi.nlm.nih.gov/pubmed/7685903
PubMed	8420959	http://www.ncbi.nlm.nih.gov/pubmed/8420959
Reactome	R-HSA-1268020	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1268020
Reactome	R-HSA-5205685	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5205685
Reactome	R-HSA-5689880	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5689880
RefSeq	NP_003365	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003365
RefSeq	XP_005272132	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005272132
RefSeq	XP_016865310	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016865310
RefSeq	XP_016865311	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016865311
RefSeq	XP_016865312	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016865312
SMR	P21796	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21796
STRING	9606.ENSP00000265333	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000265333&targetmode=cogs
UCSC	uc003kyp	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003kyp&org=rat
UniGene	Hs.519320	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.519320
UniProtKB	VDAC1_HUMAN	http://www.uniprot.org/uniprot/VDAC1_HUMAN
UniProtKB-AC	P21796	http://www.uniprot.org/uniprot/P21796
charge	swissprot:VDAC1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VDAC1_HUMAN
eggNOG	ENOG410ZBK1	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZBK1
eggNOG	KOG3126	http://eggnogapi.embl.de/nog_data/html/tree/KOG3126
epestfind	swissprot:VDAC1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VDAC1_HUMAN
garnier	swissprot:VDAC1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VDAC1_HUMAN
helixturnhelix	swissprot:VDAC1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VDAC1_HUMAN
hmoment	swissprot:VDAC1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VDAC1_HUMAN
iep	swissprot:VDAC1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VDAC1_HUMAN
inforesidue	swissprot:VDAC1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VDAC1_HUMAN
neXtProt	NX_P21796	http://www.nextprot.org/db/entry/NX_P21796
octanol	swissprot:VDAC1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VDAC1_HUMAN
pepcoil	swissprot:VDAC1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VDAC1_HUMAN
pepdigest	swissprot:VDAC1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VDAC1_HUMAN
pepinfo	swissprot:VDAC1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VDAC1_HUMAN
pepnet	swissprot:VDAC1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VDAC1_HUMAN
pepstats	swissprot:VDAC1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VDAC1_HUMAN
pepwheel	swissprot:VDAC1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VDAC1_HUMAN
pepwindow	swissprot:VDAC1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VDAC1_HUMAN
sigcleave	swissprot:VDAC1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VDAC1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S35B1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P78383-1; Sequence=Displayed; Name=2; IsoId=P78383-2; Sequence=VSP_054234; Note=No experimental confirmation available. Ref.2 (BAG57035) sequence is in conflict in position  33 S->P. Contains a phosphoserine at position 15. Contains a phosphoserine at position 29. {ECO 0000244|PubMed 20068231, ECO 0000305}; 
# AltName	S35B1_HUMAN	UDP-galactose transporter-related protein 1
# BioGrid	115531	3
# CCDS	CCDS11552	-. [P78383-2]
# DOMAIN	S35B1_HUMAN	The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins. {ECO 0000250}. 
# Ensembl	ENST00000240333	ENSP00000240333; ENSG00000121073. [P78383-2]
# ExpressionAtlas	P78383	baseline and differential
# FUNCTION	S35B1_HUMAN	Probable sugar transporter. {ECO 0000250}. 
# GO_component	GO:0030173	integral component of Golgi membrane; IBA:GO_Central.
# GO_component	GO:0030176	integral component of endoplasmic reticulum membrane; IBA:GO_Central.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; TAS:ProtInc.
# GO_function	GO:0005459	UDP-galactose transmembrane transporter activity; TAS:ProtInc.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	P78383	HS
# HGNC	HGNC:20798	SLC35B1
# IntAct	P78383	2
# InterPro	IPR013657	UAA
# KEGG_Brite	ko02001	Solute carrier family
# MIM	610790	gene
# Organism	S35B1_HUMAN	Homo sapiens (Human)
# PIR	JC5024	JC5024
# Pfam	PF08449	UAA
# Proteomes	UP000005640	Chromosome 17
# RecName	S35B1_HUMAN	Solute carrier family 35 member B1
# RefSeq	NP_005818	NM_005827.2. [P78383-2]
# SIMILARITY	Belongs to the nucleotide-sugar transporter family. SLC35B subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	S35B1_HUMAN	Endoplasmic reticulum membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	2.A.7.11	the drug/metabolite transporter (dmt) superfamily
# UCSC	uc002iph	human. [P78383-1]
# eggNOG	ENOG410IEAU	Eukaryota
# eggNOG	ENOG4111PY2	LUCA
BLAST	swissprot:S35B1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S35B1_HUMAN
BioCyc	ZFISH:ENSG00000121073-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000121073-MONOMER
COXPRESdb	10237	http://coxpresdb.jp/data/gene/10237.shtml
CleanEx	HS_SLC35B1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC35B1
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1093/oxfordjournals.jbchem.a021523	http://dx.doi.org/10.1093/oxfordjournals.jbchem.a021523
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
EMBL	AC015795	http://www.ebi.ac.uk/ena/data/view/AC015795
EMBL	AK293563	http://www.ebi.ac.uk/ena/data/view/AK293563
EMBL	BC011888	http://www.ebi.ac.uk/ena/data/view/BC011888
EMBL	CH471109	http://www.ebi.ac.uk/ena/data/view/CH471109
EMBL	D87989	http://www.ebi.ac.uk/ena/data/view/D87989
Ensembl	ENST00000240333	http://www.ensembl.org/id/ENST00000240333
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0030173	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030173
GO_component	GO:0030176	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030176
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0005459	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005459
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC35B1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC35B1
GeneID	10237	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10237
GeneTree	ENSGT00530000063090	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063090
HGNC	HGNC:20798	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20798
HOGENOM	HOG000091197	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000091197&db=HOGENOM6
HOVERGEN	HBG083706	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG083706&db=HOVERGEN
HPA	HPA057418	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA057418
InParanoid	P78383	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P78383
IntAct	P78383	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P78383*
InterPro	IPR013657	http://www.ebi.ac.uk/interpro/entry/IPR013657
Jabion	10237	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10237
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:10237	http://www.genome.jp/dbget-bin/www_bget?hsa:10237
KEGG_Orthology	KO:K15275	http://www.genome.jp/dbget-bin/www_bget?KO:K15275
MIM	610790	http://www.ncbi.nlm.nih.gov/omim/610790
OMA	FVCYFYF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FVCYFYF
OrthoDB	EOG091G0LP3	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0LP3
PSORT	swissprot:S35B1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S35B1_HUMAN
PSORT-B	swissprot:S35B1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S35B1_HUMAN
PSORT2	swissprot:S35B1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S35B1_HUMAN
Pfam	PF08449	http://pfam.xfam.org/family/PF08449
PharmGKB	PA134864001	http://www.pharmgkb.org/do/serve?objId=PA134864001&objCls=Gene
Phobius	swissprot:S35B1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S35B1_HUMAN
PhylomeDB	P78383	http://phylomedb.org/?seqid=P78383
ProteinModelPortal	P78383	http://www.proteinmodelportal.org/query/uniprot/P78383
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	9010752	http://www.ncbi.nlm.nih.gov/pubmed/9010752
RefSeq	NP_005818	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005818
STRING	9606.ENSP00000240333	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000240333&targetmode=cogs
TCDB	2.A.7.11	http://www.tcdb.org/search/result.php?tc=2.A.7.11
UCSC	uc002iph	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002iph&org=rat
UniGene	Hs.154073	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.154073
UniProtKB	S35B1_HUMAN	http://www.uniprot.org/uniprot/S35B1_HUMAN
UniProtKB-AC	P78383	http://www.uniprot.org/uniprot/P78383
charge	swissprot:S35B1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S35B1_HUMAN
eggNOG	ENOG410IEAU	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IEAU
eggNOG	ENOG4111PY2	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111PY2
epestfind	swissprot:S35B1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S35B1_HUMAN
garnier	swissprot:S35B1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S35B1_HUMAN
helixturnhelix	swissprot:S35B1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S35B1_HUMAN
hmoment	swissprot:S35B1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S35B1_HUMAN
iep	swissprot:S35B1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S35B1_HUMAN
inforesidue	swissprot:S35B1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S35B1_HUMAN
neXtProt	NX_P78383	http://www.nextprot.org/db/entry/NX_P78383
octanol	swissprot:S35B1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S35B1_HUMAN
pepcoil	swissprot:S35B1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S35B1_HUMAN
pepdigest	swissprot:S35B1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S35B1_HUMAN
pepinfo	swissprot:S35B1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S35B1_HUMAN
pepnet	swissprot:S35B1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S35B1_HUMAN
pepstats	swissprot:S35B1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S35B1_HUMAN
pepwheel	swissprot:S35B1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S35B1_HUMAN
pepwindow	swissprot:S35B1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S35B1_HUMAN
sigcleave	swissprot:S35B1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S35B1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNG3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Kv10.1b; IsoId=Q8TAE7-1; Sequence=Displayed; Name=2; Synonyms=Kv10.1a; IsoId=Q8TAE7-2; Sequence=VSP_001026; 
# AltName	KCNG3_HUMAN	Voltage-gated potassium channel subunit Kv10.1
# AltName	KCNG3_HUMAN	Voltage-gated potassium channel subunit Kv6.3
# BioGrid	128090	4
# CCDS	CCDS1809	-. [Q8TAE7-1]
# CCDS	CCDS42674	-. [Q8TAE7-2]
# DOMAIN	KCNG3_HUMAN	The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. {ECO 0000250|UniProtKB P63142}. 
# Ensembl	ENST00000306078	ENSP00000304127; ENSG00000171126. [Q8TAE7-1]
# Ensembl	ENST00000394973	ENSP00000378424; ENSG00000171126. [Q8TAE7-2]
# FUNCTION	KCNG3_HUMAN	Potassium channel subunit that does not form functional channels by itself (PubMed 11852086). Can form functional heterotetrameric channels with KCNB1; this promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1 (PubMed 11852086, PubMed 19074135). {ECO 0000269|PubMed 11852086, ECO 0000269|PubMed 19074135}. 
# GO_component	GO:0005783	endoplasmic reticulum; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IEA:InterPro.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; IDA:UniProtKB.
# GO_process	GO:0051260	protein homooligomerization; IEA:InterPro.
# GO_process	GO:0071805	potassium ion transmembrane transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.350	-; 1.
# Genevisible	Q8TAE7	HS
# HGNC	HGNC:18306	KCNG3
# InterPro	IPR000210	BTB/POZ_dom
# InterPro	IPR003131	T1-type_BTB
# InterPro	IPR003968	K_chnl_volt-dep_Kv
# InterPro	IPR003971	K_chnl_volt-dep_Kv9
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR011333	SKP1/BTB/POZ
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko04040	Ion channels
# MIM	606767	gene
# Organism	KCNG3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11537	PTHR11537
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01491	KVCHANNEL
# PRINTS	PR01494	KV9CHANNEL
# Pfam	PF00520	Ion_trans
# Pfam	PF02214	BTB_2
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# RecName	KCNG3_HUMAN	Potassium voltage-gated channel subfamily G member 3
# RefSeq	NP_579875	NM_133329.5. [Q8TAE7-1]
# RefSeq	NP_758847	NM_172344.2. [Q8TAE7-2]
# SIMILARITY	Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.3/KCNG3 sub-subfamily. {ECO	0000305}.
# SMART	SM00225	BTB
# SUBCELLULAR LOCATION	KCNG3_HUMAN	Cell membrane {ECO 0000269|PubMed 11852086, ECO 0000269|PubMed 12060745, ECO 0000269|PubMed 19074135}; Multi- pass membrane protein {ECO 0000305}. Cytoplasm {ECO 0000269|PubMed 12060745}. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane (PubMed 12060745). Colocalizes with KCNB1 at the plasma membrane (PubMed 12060745, PubMed 19074135). Remains intracellular in the absence of KCNB1 (PubMed 12060745). {ECO 0000269|PubMed 12060745, ECO 0000269|PubMed 19074135}. 
# SUBUNIT	KCNG3_HUMAN	Heterotetramer with KCNB1 (PubMed 11852086, PubMed 12060745, PubMed 19074135). Does not form homomultimers (PubMed 12060745). {ECO 0000269|PubMed 11852086, ECO 0000269|PubMed 12060745, ECO 0000269|PubMed 19074135}. 
# SUPFAM	SSF54695	SSF54695
# TISSUE SPECIFICITY	KCNG3_HUMAN	Expressed in the brain, liver, testis, small intestine, colon, thymus and adrenal gland (PubMed 11852086, PubMed 12060745). {ECO 0000269|PubMed 11852086, ECO 0000269|PubMed 12060745}. 
# UCSC	uc002rsm	human. [Q8TAE7-1]
# eggNOG	COG1226	LUCA
# eggNOG	KOG3713	Eukaryota
BLAST	swissprot:KCNG3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNG3_HUMAN
BioCyc	ZFISH:ENSG00000171126-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000171126-MONOMER
COXPRESdb	170850	http://coxpresdb.jp/data/gene/170850.shtml
CleanEx	HS_KCNG3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNG3
DOI	10.1016/S0014-5793(02)02267-6	http://dx.doi.org/10.1016/S0014-5793(02)02267-6
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1073/pnas.122617999	http://dx.doi.org/10.1073/pnas.122617999
DOI	10.1074/jbc.M808786200	http://dx.doi.org/10.1074/jbc.M808786200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB070604	http://www.ebi.ac.uk/ena/data/view/AB070604
EMBL	AC025750	http://www.ebi.ac.uk/ena/data/view/AC025750
EMBL	AF348982	http://www.ebi.ac.uk/ena/data/view/AF348982
EMBL	AF454547	http://www.ebi.ac.uk/ena/data/view/AF454547
EMBL	AF454548	http://www.ebi.ac.uk/ena/data/view/AF454548
EMBL	BC071558	http://www.ebi.ac.uk/ena/data/view/BC071558
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
Ensembl	ENST00000306078	http://www.ensembl.org/id/ENST00000306078
Ensembl	ENST00000394973	http://www.ensembl.org/id/ENST00000394973
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	KCNG3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNG3
GeneID	170850	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=170850
GeneTree	ENSGT00760000118981	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118981
HGNC	HGNC:18306	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18306
HOGENOM	HOG000231014	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231014&db=HOGENOM6
HOVERGEN	HBG100172	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG100172&db=HOVERGEN
InParanoid	Q8TAE7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8TAE7
IntAct	Q8TAE7	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8TAE7*
InterPro	IPR000210	http://www.ebi.ac.uk/interpro/entry/IPR000210
InterPro	IPR003131	http://www.ebi.ac.uk/interpro/entry/IPR003131
InterPro	IPR003968	http://www.ebi.ac.uk/interpro/entry/IPR003968
InterPro	IPR003971	http://www.ebi.ac.uk/interpro/entry/IPR003971
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR011333	http://www.ebi.ac.uk/interpro/entry/IPR011333
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	170850	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=170850
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:170850	http://www.genome.jp/dbget-bin/www_bget?hsa:170850
KEGG_Orthology	KO:K04902	http://www.genome.jp/dbget-bin/www_bget?KO:K04902
MIM	606767	http://www.ncbi.nlm.nih.gov/omim/606767
OMA	DMYPITM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DMYPITM
OrthoDB	EOG091G09VX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G09VX
PANTHER	PTHR11537	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01491	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01491
PRINTS	PR01494	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01494
PSORT	swissprot:KCNG3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNG3_HUMAN
PSORT-B	swissprot:KCNG3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNG3_HUMAN
PSORT2	swissprot:KCNG3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNG3_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF02214	http://pfam.xfam.org/family/PF02214
PharmGKB	PA30036	http://www.pharmgkb.org/do/serve?objId=PA30036&objCls=Gene
Phobius	swissprot:KCNG3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNG3_HUMAN
PhylomeDB	Q8TAE7	http://phylomedb.org/?seqid=Q8TAE7
ProteinModelPortal	Q8TAE7	http://www.proteinmodelportal.org/query/uniprot/Q8TAE7
PubMed	11852086	http://www.ncbi.nlm.nih.gov/pubmed/11852086
PubMed	12060745	http://www.ncbi.nlm.nih.gov/pubmed/12060745
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	19074135	http://www.ncbi.nlm.nih.gov/pubmed/19074135
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
RefSeq	NP_579875	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_579875
RefSeq	NP_758847	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_758847
SMART	SM00225	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225
STRING	9606.ENSP00000304127	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000304127&targetmode=cogs
SUPFAM	SSF54695	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54695
UCSC	uc002rsm	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002rsm&org=rat
UniGene	Hs.352633	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.352633
UniProtKB	KCNG3_HUMAN	http://www.uniprot.org/uniprot/KCNG3_HUMAN
UniProtKB-AC	Q8TAE7	http://www.uniprot.org/uniprot/Q8TAE7
charge	swissprot:KCNG3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNG3_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG3713	http://eggnogapi.embl.de/nog_data/html/tree/KOG3713
epestfind	swissprot:KCNG3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNG3_HUMAN
garnier	swissprot:KCNG3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNG3_HUMAN
helixturnhelix	swissprot:KCNG3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNG3_HUMAN
hmoment	swissprot:KCNG3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNG3_HUMAN
iep	swissprot:KCNG3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNG3_HUMAN
inforesidue	swissprot:KCNG3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNG3_HUMAN
neXtProt	NX_Q8TAE7	http://www.nextprot.org/db/entry/NX_Q8TAE7
octanol	swissprot:KCNG3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNG3_HUMAN
pepcoil	swissprot:KCNG3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNG3_HUMAN
pepdigest	swissprot:KCNG3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNG3_HUMAN
pepinfo	swissprot:KCNG3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNG3_HUMAN
pepnet	swissprot:KCNG3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNG3_HUMAN
pepstats	swissprot:KCNG3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNG3_HUMAN
pepwheel	swissprot:KCNG3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNG3_HUMAN
pepwindow	swissprot:KCNG3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNG3_HUMAN
sigcleave	swissprot:KCNG3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNG3_HUMAN
## Database	ID	URL or Descriptions
# AltName	MOT11_HUMAN	Solute carrier family 16 member 11
# BioGrid	127822	4
# CAUTION	It is uncertain whether Met-1 or Met-25 is the initiator. {ECO	0000305}.
# CDD	cd06174	MFS
# DISEASE	MOT11_HUMAN	Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM 125853]  A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO 0000269|PubMed 24390345}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Variants Ile-113, Gly-127, Ser-340 and Thr-443 are individually associated with a 20% increased risk of NIDDM. These variants are present at 50% frequency in Native-American samples, 10% in east Asian, while they are rare in European and African samples populations. These haplotypes probably derive from H.sapiens neanderthalensis (Neanderthal) introgression (PubMed 24390345). {ECO 0000269|PubMed 24390345}. 
# Ensembl	ENST00000308009	ENSP00000310490; ENSG00000174326
# ExpressionAtlas	Q8NCK7	baseline and differential
# FUNCTION	MOT11_HUMAN	Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane (Probable). Probably involved in hepatic lipid metabolism  overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids. {ECO 0000269|PubMed 24390345, ECO 0000305}. 
# GO_component	GO:0005789	endoplasmic reticulum membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0015129	lactate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_process	GO:0006629	lipid metabolic process; IDA:UniProtKB.
# GO_process	GO:0035879	plasma membrane lactate transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q8NCK7	HS
# HGNC	HGNC:23093	SLC16A11
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# InterPro	IPR030769	MCT11
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	125853	phenotype
# Organism	MOT11_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11360:SF80	PTHR11360:SF80
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 17
# RecName	MOT11_HUMAN	Monocarboxylate transporter 11
# RefSeq	NP_699188	NM_153357.1
# SIMILARITY	Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	MOT11_HUMAN	Endoplasmic reticulum membrane {ECO 0000269|PubMed 24390345}; Multi-pass membrane protein {ECO 0000255}. Cell membrane {ECO 0000255}; Multi-pass membrane protein {ECO 0000255}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.13.13	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	Expressed in liver, salivary gland and thyroid. {ECO:0000269|PubMed	24390345}. 
# UCSC	uc002gei	human
# eggNOG	COG0477	LUCA
# eggNOG	KOG2504	Eukaryota
BLAST	swissprot:MOT11_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MOT11_HUMAN
BioCyc	ZFISH:ENSG00000174326-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000174326-MONOMER
COXPRESdb	162515	http://coxpresdb.jp/data/gene/162515.shtml
CleanEx	HS_SLC16A11	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC16A11
DOI	10.1038/nature12828	http://dx.doi.org/10.1038/nature12828
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AK074674	http://www.ebi.ac.uk/ena/data/view/AK074674
EMBL	BC093860	http://www.ebi.ac.uk/ena/data/view/BC093860
EMBL	BC093886	http://www.ebi.ac.uk/ena/data/view/BC093886
Ensembl	ENST00000308009	http://www.ensembl.org/id/ENST00000308009
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0015129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015129
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GO_process	GO:0035879	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035879
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC16A11	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC16A11
GeneID	162515	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=162515
GeneTree	ENSGT00760000118926	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118926
HGNC	HGNC:23093	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:23093
HOGENOM	HOG000280688	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280688&db=HOGENOM6
HOVERGEN	HBG106552	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG106552&db=HOVERGEN
InParanoid	Q8NCK7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8NCK7
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
InterPro	IPR030769	http://www.ebi.ac.uk/interpro/entry/IPR030769
Jabion	162515	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=162515
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:162515	http://www.genome.jp/dbget-bin/www_bget?hsa:162515
KEGG_Orthology	KO:K08188	http://www.genome.jp/dbget-bin/www_bget?KO:K08188
MIM	125853	http://www.ncbi.nlm.nih.gov/omim/125853
OMA	QDTAWIS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QDTAWIS
OrthoDB	EOG091G0JKH	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0JKH
PANTHER	PTHR11360:SF80	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11360:SF80
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:MOT11_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MOT11_HUMAN
PSORT-B	swissprot:MOT11_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MOT11_HUMAN
PSORT2	swissprot:MOT11_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MOT11_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA134976903	http://www.pharmgkb.org/do/serve?objId=PA134976903&objCls=Gene
Phobius	swissprot:MOT11_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MOT11_HUMAN
PhylomeDB	Q8NCK7	http://phylomedb.org/?seqid=Q8NCK7
ProteinModelPortal	Q8NCK7	http://www.proteinmodelportal.org/query/uniprot/Q8NCK7
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	24390345	http://www.ncbi.nlm.nih.gov/pubmed/24390345
RefSeq	NP_699188	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_699188
STRING	9606.ENSP00000310490	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000310490&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.13.13	http://www.tcdb.org/search/result.php?tc=2.A.1.13.13
UCSC	uc002gei	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002gei&org=rat
UniGene	Hs.336564	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.336564
UniProtKB	MOT11_HUMAN	http://www.uniprot.org/uniprot/MOT11_HUMAN
UniProtKB-AC	Q8NCK7	http://www.uniprot.org/uniprot/Q8NCK7
charge	swissprot:MOT11_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MOT11_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG2504	http://eggnogapi.embl.de/nog_data/html/tree/KOG2504
epestfind	swissprot:MOT11_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MOT11_HUMAN
garnier	swissprot:MOT11_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MOT11_HUMAN
helixturnhelix	swissprot:MOT11_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MOT11_HUMAN
hmoment	swissprot:MOT11_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MOT11_HUMAN
iep	swissprot:MOT11_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MOT11_HUMAN
inforesidue	swissprot:MOT11_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MOT11_HUMAN
neXtProt	NX_Q8NCK7	http://www.nextprot.org/db/entry/NX_Q8NCK7
octanol	swissprot:MOT11_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MOT11_HUMAN
pepcoil	swissprot:MOT11_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MOT11_HUMAN
pepdigest	swissprot:MOT11_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MOT11_HUMAN
pepinfo	swissprot:MOT11_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MOT11_HUMAN
pepnet	swissprot:MOT11_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MOT11_HUMAN
pepstats	swissprot:MOT11_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MOT11_HUMAN
pepwheel	swissprot:MOT11_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MOT11_HUMAN
pepwindow	swissprot:MOT11_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MOT11_HUMAN
sigcleave	swissprot:MOT11_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MOT11_HUMAN
## Database	ID	URL or Descriptions
# AltName	CXG2_HUMAN	Connexin-46.6
# AltName	CXG2_HUMAN	Connexin-47
# AltName	CXG2_HUMAN	Gap junction alpha-12 protein
# CAUTION	It is uncertain whether Met-1 or Met-4 is the initiator. {ECO	0000305}. 
# DISEASE	CXG2_HUMAN	Leukodystrophy, hypomyelinating, 2 (HLD2) [MIM 608804]  An autosomal recessive hypomyelinating leukodystrophy with symptoms of Pelizaeus-Merzbacher disease. Clinically characterized by nystagmus, impaired motor development, ataxia, choreoathetotic movements, dysarthria, and progressive spasticity. {ECO 0000269|PubMed 15192806}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CXG2_HUMAN	Lymphedema, hereditary, 1C (LMPH1C) [MIM 613480]  A chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections and physical impairment. {ECO 0000269|PubMed 20537300}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CXG2_HUMAN	Spastic paraplegia 44, autosomal recessive (SPG44) [MIM 613206]  A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. {ECO 0000269|PubMed 19056803}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000366714	ENSP00000355675; ENSG00000198835
# FUNCTION	CXG2_HUMAN	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems. {ECO 0000269|PubMed 15192806}. 
# GO_component	GO:0005922	connexin complex; IEA:InterPro.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0043209	myelin sheath; IEA:Ensembl.
# GO_function	GO:0005243	gap junction channel activity; IEA:Ensembl.
# GO_process	GO:0007267	cell-cell signaling; IEA:Ensembl.
# GO_process	GO:0009636	response to toxic substance; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q5T442	HS
# HGNC	HGNC:17494	GJC2
# InterPro	IPR000500	Connexin
# InterPro	IPR013092	Connexin_N
# InterPro	IPR017990	Connexin_CS
# InterPro	IPR019570	Connexin_CCC
# KEGG_Disease	H00266	[Nervous system disease; Muscular disease] Hereditary spastic paraplegia (SPG)
# KEGG_Disease	H00679	[Inherited metabolic disease; Nervous system disease] Pelizaeus-Merzbacher disease (PMD)
# MIM	608803	gene
# MIM	608804	phenotype
# MIM	613206	phenotype
# MIM	613480	phenotype
# Organism	CXG2_HUMAN	Homo sapiens (Human)
# Orphanet	280282	Pelizaeus-Merzbacher-like disease due to GJC2 mutation
# Orphanet	320401	Autosomal recessive spastic paraplegia type 44
# Orphanet	79452	Milroy disease
# PANTHER	PTHR11984	PTHR11984; 2
# PRINTS	PR00206	CONNEXIN
# PROSITE	PS00407	CONNEXINS_1
# PROSITE	PS00408	CONNEXINS_2
# Pfam	PF00029	Connexin
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-190861	Gap junction assembly
# RecName	CXG2_HUMAN	Gap junction gamma-2 protein
# RefSeq	NP_065168	NM_020435.3
# SEQUENCE CAUTION	Sequence=AAB94511.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH35840.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the connexin family. Gamma-type subfamily. {ECO	0000305}. 
# SMART	SM00037	CNX
# SMART	SM01089	Connexin_CCC
# SUBCELLULAR LOCATION	CXG2_HUMAN	Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. 
# SUBUNIT	A connexon is composed of a hexamer of connexins. Interacts with TJP1 (By similarity). {ECO	0000250}. 
# TISSUE SPECIFICITY	Expressed in central nervous system, in sciatic nerve and sural nerve. Also detected in skeletal muscles. {ECO:0000269|PubMed	15192806}. 
# UCSC	uc001hsk	human
# eggNOG	ENOG410IFK3	Eukaryota
# eggNOG	ENOG410Z7PN	LUCA
BLAST	swissprot:CXG2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CXG2_HUMAN
BioCyc	ZFISH:G66-33535-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33535-MONOMER
COXPRESdb	57165	http://coxpresdb.jp/data/gene/57165.shtml
CleanEx	HS_GJC2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GJC2
DOI	10.1016/j.ajhg.2010.04.010	http://dx.doi.org/10.1016/j.ajhg.2010.04.010
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1086/422763	http://dx.doi.org/10.1086/422763
DOI	10.1093/brain/awn328	http://dx.doi.org/10.1093/brain/awn328
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF014643	http://www.ebi.ac.uk/ena/data/view/AF014643
EMBL	AL359510	http://www.ebi.ac.uk/ena/data/view/AL359510
EMBL	AY285161	http://www.ebi.ac.uk/ena/data/view/AY285161
EMBL	BC035840	http://www.ebi.ac.uk/ena/data/view/BC035840
EMBL	BC089439	http://www.ebi.ac.uk/ena/data/view/BC089439
Ensembl	ENST00000366714	http://www.ensembl.org/id/ENST00000366714
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005922	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005922
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0043209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043209
GO_function	GO:0005243	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005243
GO_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GO_process	GO:0009636	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009636
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	GJC2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GJC2
GeneID	57165	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57165
GeneTree	ENSGT00840000129674	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00840000129674
HGNC	HGNC:17494	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17494
HOGENOM	HOG000231126	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231126&db=HOGENOM6
HOVERGEN	HBG009576	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG009576&db=HOVERGEN
InParanoid	Q5T442	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q5T442
IntAct	Q5T442	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q5T442*
InterPro	IPR000500	http://www.ebi.ac.uk/interpro/entry/IPR000500
InterPro	IPR013092	http://www.ebi.ac.uk/interpro/entry/IPR013092
InterPro	IPR017990	http://www.ebi.ac.uk/interpro/entry/IPR017990
InterPro	IPR019570	http://www.ebi.ac.uk/interpro/entry/IPR019570
Jabion	57165	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=57165
KEGG_Disease	H00266	http://www.genome.jp/dbget-bin/www_bget?H00266
KEGG_Disease	H00679	http://www.genome.jp/dbget-bin/www_bget?H00679
KEGG_Gene	hsa:57165	http://www.genome.jp/dbget-bin/www_bget?hsa:57165
KEGG_Orthology	KO:K07619	http://www.genome.jp/dbget-bin/www_bget?KO:K07619
MIM	608803	http://www.ncbi.nlm.nih.gov/omim/608803
MIM	608804	http://www.ncbi.nlm.nih.gov/omim/608804
MIM	613206	http://www.ncbi.nlm.nih.gov/omim/613206
MIM	613480	http://www.ncbi.nlm.nih.gov/omim/613480
OMA	DRDSPPC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DRDSPPC
Orphanet	280282	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=280282
Orphanet	320401	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=320401
Orphanet	79452	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=79452
OrthoDB	EOG091G08B8	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08B8
PANTHER	PTHR11984	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11984
PRINTS	PR00206	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00206
PROSITE	PS00407	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00407
PROSITE	PS00408	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00408
PSORT	swissprot:CXG2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CXG2_HUMAN
PSORT-B	swissprot:CXG2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CXG2_HUMAN
PSORT2	swissprot:CXG2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CXG2_HUMAN
Pfam	PF00029	http://pfam.xfam.org/family/PF00029
PharmGKB	PA162389696	http://www.pharmgkb.org/do/serve?objId=PA162389696&objCls=Gene
Phobius	swissprot:CXG2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CXG2_HUMAN
PhylomeDB	Q5T442	http://phylomedb.org/?seqid=Q5T442
ProteinModelPortal	Q5T442	http://www.proteinmodelportal.org/query/uniprot/Q5T442
PubMed	15192806	http://www.ncbi.nlm.nih.gov/pubmed/15192806
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	19056803	http://www.ncbi.nlm.nih.gov/pubmed/19056803
PubMed	20537300	http://www.ncbi.nlm.nih.gov/pubmed/20537300
Reactome	R-HSA-190861	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-190861
RefSeq	NP_065168	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_065168
SMART	SM00037	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00037
SMART	SM01089	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01089
STRING	9606.ENSP00000355675	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000355675&targetmode=cogs
UCSC	uc001hsk	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001hsk&org=rat
UniGene	Hs.100072	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.100072
UniGene	Hs.743715	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.743715
UniProtKB	CXG2_HUMAN	http://www.uniprot.org/uniprot/CXG2_HUMAN
UniProtKB-AC	Q5T442	http://www.uniprot.org/uniprot/Q5T442
charge	swissprot:CXG2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CXG2_HUMAN
eggNOG	ENOG410IFK3	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IFK3
eggNOG	ENOG410Z7PN	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z7PN
epestfind	swissprot:CXG2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CXG2_HUMAN
garnier	swissprot:CXG2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CXG2_HUMAN
helixturnhelix	swissprot:CXG2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CXG2_HUMAN
hmoment	swissprot:CXG2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CXG2_HUMAN
iep	swissprot:CXG2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CXG2_HUMAN
inforesidue	swissprot:CXG2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CXG2_HUMAN
neXtProt	NX_Q5T442	http://www.nextprot.org/db/entry/NX_Q5T442
octanol	swissprot:CXG2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CXG2_HUMAN
pepcoil	swissprot:CXG2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CXG2_HUMAN
pepdigest	swissprot:CXG2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CXG2_HUMAN
pepinfo	swissprot:CXG2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CXG2_HUMAN
pepnet	swissprot:CXG2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CXG2_HUMAN
pepstats	swissprot:CXG2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CXG2_HUMAN
pepwheel	swissprot:CXG2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CXG2_HUMAN
pepwindow	swissprot:CXG2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CXG2_HUMAN
sigcleave	swissprot:CXG2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CXG2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S4A4_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=hcNBC, hhNBC, hNBC1, pNBC, pNCB1, pNBC-1, NBC1b; IsoId=Q9Y6R1-1; Sequence=Displayed; Name=2; Synonyms=hkNBC, hkNBCe1, kNBC, kNBC1, kNBC-1, NBC1a; IsoId=Q9Y6R1-2; Sequence=VSP_016704, VSP_016705; Name=3; IsoId=Q9Y6R1-3; Sequence=VSP_016704, VSP_016705, VSP_016706, VSP_016707; Name=4; IsoId=Q9Y6R1-4; Sequence=VSP_016708; Name=5; IsoId=Q9Y6R1-5; Sequence=VSP_041003; 
# AltName	S4A4_HUMAN	Na(+)/HCO3(-) cotransporter
# AltName	S4A4_HUMAN	Solute carrier family 4 member 4
# AltName	S4A4_HUMAN	kNBC1
# CCDS	CCDS3549	-. [Q9Y6R1-2]
# CCDS	CCDS43236	-. [Q9Y6R1-1]
# CCDS	CCDS47071	-. [Q9Y6R1-5]
# ChiTaRS	SLC4A4	human
# DISEASE	S4A4_HUMAN	Note=Loss of interaction with and stimulation by CA4 is the cause of retinitis pigmentosa type 17 (RP17). 
# DISEASE	S4A4_HUMAN	Renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) [MIM 604278]  An extremely rare autosomal recessive syndrome characterized by short stature, profound proximal renal tubular acidosis, mental retardation, bilateral glaucoma, cataracts and bandkeratopathy. pRTA is due to a failure of the proximal tubular cells to reabsorb filtered bicarbonate from the urine, leading to urinary bicarbonate wasting and subsequent acidemia. {ECO 0000269|PubMed 10545938, ECO 0000269|PubMed 15471865, ECO 0000269|PubMed 15713912, ECO 0000269|PubMed 15930088, ECO 0000269|PubMed 16636648, ECO 0000269|PubMed 17661077}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB01390	Sodium bicarbonate
# ENZYME REGULATION	S4A4_HUMAN	Inhibited by stilbene derivatives and regulated by cyclic AMP. 
# Ensembl	ENST00000264485	ENSP00000264485; ENSG00000080493. [Q9Y6R1-1]
# Ensembl	ENST00000340595	ENSP00000344272; ENSG00000080493. [Q9Y6R1-2]
# Ensembl	ENST00000351898	ENSP00000307349; ENSG00000080493. [Q9Y6R1-4]
# Ensembl	ENST00000425175	ENSP00000393557; ENSG00000080493. [Q9Y6R1-5]
# Ensembl	ENST00000512686	ENSP00000422400; ENSG00000080493. [Q9Y6R1-3]
# ExpressionAtlas	Q9Y6R1	baseline and differential
# FUNCTION	S4A4_HUMAN	Electrogenic sodium/bicarbonate cotransporter with a Na(+) HCO3(-) stoichiometry varying from 1 2 to 1 3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO 0000269|PubMed 10069984, ECO 0000269|PubMed 12907161, ECO 0000269|PubMed 16636648, ECO 0000269|PubMed 16769890, ECO 0000269|PubMed 17661077, ECO 0000269|PubMed 9235899, ECO 0000269|PubMed 9651366}. 
# FUNCTION	S4A4_HUMAN	Isoform 2  May have a higher activity than isoform 1. {ECO 0000269|PubMed 16769890}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016323	basolateral plasma membrane; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005452	inorganic anion exchanger activity; IEA:InterPro.
# GO_function	S4A4_HUMAN	GO 0008510 sodium bicarbonate symporter activity; IMP UniProtKB.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006814	sodium ion transport; IDA:UniProtKB.
# GO_process	GO:0015701	bicarbonate transport; TAS:Reactome.
# GO_process	GO:0051453	regulation of intracellular pH; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0042592	homeostatic process
# Gene3D	3.40.1100.10	-; 1.
# Genevisible	Q9Y6R1	HS
# HGNC	HGNC:11030	SLC4A4
# INTERACTION	S4A4_HUMAN	P48283 CA4 (xeno); NbExp=2; IntAct=EBI-6859278, EBI-6859264; 
# IntAct	Q9Y6R1	4
# InterPro	IPR003020	HCO3_transpt_euk
# InterPro	IPR003024	Na/HCO3_transpt
# InterPro	IPR011531	HCO3_transpt_C
# InterPro	IPR013769	Band3_cytoplasmic_dom
# InterPro	IPR016152	PTrfase/Anion_transptr
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H00429	[Urinary system disease] Proximal renal tubular acidosis (RTA type 2)
# KEGG_Pathway	ko04964	Proximal tubule bicarbonate reclamation
# KEGG_Pathway	ko04972	Pancreatic secretion
# KEGG_Pathway	ko04976	Bile secretion
# MIM	603345	gene
# MIM	604278	phenotype
# Organism	S4A4_HUMAN	Homo sapiens (Human)
# Orphanet	93607	Autosomal recessive proximal renal tubular acidosis
# PANTHER	PTHR11453	PTHR11453; 2
# PRINTS	PR01231	HCO3TRNSPORT
# PRINTS	PR01232	NAHCO3TRSPRT
# PTM	S4A4_HUMAN	N-glycosylation is not necessary for the transporter basic functions. {ECO 0000269|PubMed 12604466}. 
# PTM	S4A4_HUMAN	Phosphorylation of Ser-1026 by PKA increases the binding of CA2 and changes the Na(+) HCO3(-) stoichiometry of the transporter from 3 1 to 2 1. Phosphorylated in presence of STK39 and dephosphorylated in presence of PP1 phosphatase; phosphorylation seems to inhibit SLC4A4 activity. {ECO 0000250|UniProtKB O88343, ECO 0000269|PubMed 11744745, ECO 0000269|PubMed 12730338}. 
# Pfam	PF00955	HCO3_cotransp
# Pfam	PF07565	Band_3_cyto
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-425381	Bicarbonate transporters
# RecName	S4A4_HUMAN	Electrogenic sodium bicarbonate cotransporter 1
# RefSeq	NP_001091954	NM_001098484.2. [Q9Y6R1-1]
# RefSeq	NP_003750	NM_003759.3. [Q9Y6R1-2]
# SIMILARITY	Belongs to the anion exchanger (TC 2.A.31) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S4A4_HUMAN	Basolateral cell membrane {ECO 0000269|PubMed 12907161, ECO 0000269|PubMed 15273250, ECO 0000269|PubMed 16636648, ECO 0000269|PubMed 17661077}; Multi- pass membrane protein {ECO 0000269|PubMed 12907161, ECO 0000269|PubMed 15273250}. 
# SUBUNIT	S4A4_HUMAN	Interacts with CA2/carbonic anhydrase 2 and CA4/carbonic anhydrase 4 which may regulate transporter activity (PubMed 12411514, PubMed 14567693, PubMed 15218065, PubMed 15563508). Isoform 1 but not isoform 2 interacts with AHCYL1 (via PEST domain when phosphorylated); the interaction increases SLC4A4 isoform 1 activity (PubMed 16769890). Interacts with AHCYL2 (By similarity). {ECO 0000250|UniProtKB O88343, ECO 0000250|UniProtKB Q9GL77, ECO 0000269|PubMed 12411514, ECO 0000269|PubMed 14567693, ECO 0000269|PubMed 15218065, ECO 0000269|PubMed 15563508, ECO 0000269|PubMed 16769890}. 
# SUPFAM	SSF55804	SSF55804
# TCDB	2.A.31.2.12	the anion exchanger (ae) family
# TIGRFAMs	TIGR00834	ae
# TISSUE SPECIFICITY	S4A4_HUMAN	Isoform 1 is expressed in pancreas and to a lower extent in heart, skeletal muscle, liver, parotid salivary glands, prostate, colon, stomach, thyroid, brain and spinal chord. Corneal endothelium cells express only isoform 1 (at protein level). Isoform 2 is specifically expressed in kidney at the level of proximal tubules. {ECO 0000269|PubMed 10069984, ECO 0000269|PubMed 11743927, ECO 0000269|PubMed 12907161, ECO 0000269|PubMed 14559244, ECO 0000269|PubMed 15329059, ECO 0000269|PubMed 9235899, ECO 0000269|PubMed 9651366}. 
# UCSC	uc003hfy	human. [Q9Y6R1-1]
# eggNOG	ENOG410XPHD	LUCA
# eggNOG	KOG1172	Eukaryota
BLAST	swissprot:S4A4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S4A4_HUMAN
COXPRESdb	8671	http://coxpresdb.jp/data/gene/8671.shtml
CleanEx	HS_SLC4A4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC4A4
DIP	DIP-59373N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-59373N
DOI	10.1007/s00424-007-0319-y	http://dx.doi.org/10.1007/s00424-007-0319-y
DOI	10.1016/S0003-9969(01)00098-X	http://dx.doi.org/10.1016/S0003-9969(01)00098-X
DOI	10.1016/S0014-4835(03)00150-7	http://dx.doi.org/10.1016/S0014-4835(03)00150-7
DOI	10.1016/j.bbrc.2003.09.147	http://dx.doi.org/10.1016/j.bbrc.2003.09.147
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/bi026826q	http://dx.doi.org/10.1021/bi026826q
DOI	10.1021/bi0353124	http://dx.doi.org/10.1021/bi0353124
DOI	10.1038/15440	http://dx.doi.org/10.1038/15440
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1073/pnas.0602250103	http://dx.doi.org/10.1073/pnas.0602250103
DOI	10.1074/jbc.272.31.19111	http://dx.doi.org/10.1074/jbc.272.31.19111
DOI	10.1074/jbc.273.28.17689	http://dx.doi.org/10.1074/jbc.273.28.17689
DOI	10.1074/jbc.M114.619320	http://dx.doi.org/10.1074/jbc.M114.619320
DOI	10.1074/jbc.M405780200	http://dx.doi.org/10.1074/jbc.M405780200
DOI	10.1074/jbc.M406591200	http://dx.doi.org/10.1074/jbc.M406591200
DOI	10.1093/hmg/ddi023	http://dx.doi.org/10.1093/hmg/ddi023
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1365-201X.2004.01297.x	http://dx.doi.org/10.1111/j.1365-201X.2004.01297.x
DOI	10.1113/jphysiol.2001.012956	http://dx.doi.org/10.1113/jphysiol.2001.012956
DOI	10.1113/jphysiol.2002.029777	http://dx.doi.org/10.1113/jphysiol.2002.029777
DOI	10.1113/jphysiol.2003.042226	http://dx.doi.org/10.1113/jphysiol.2003.042226
DOI	10.1113/jphysiol.2004.065110	http://dx.doi.org/10.1113/jphysiol.2004.065110
DOI	10.1113/jphysiol.2005.084988	http://dx.doi.org/10.1113/jphysiol.2005.084988
DOI	10.1152/ajprenal.00032.2005	http://dx.doi.org/10.1152/ajprenal.00032.2005
DOI	10.1152/ajprenal.00131.2002	http://dx.doi.org/10.1152/ajprenal.00131.2002
DOI	10.1681/ASN.2004080667	http://dx.doi.org/10.1681/ASN.2004080667
DrugBank	DB01390	http://www.drugbank.ca/drugs/DB01390
EMBL	AB470072	http://www.ebi.ac.uk/ena/data/view/AB470072
EMBL	AC019089	http://www.ebi.ac.uk/ena/data/view/AC019089
EMBL	AC079230	http://www.ebi.ac.uk/ena/data/view/AC079230
EMBL	AC096713	http://www.ebi.ac.uk/ena/data/view/AC096713
EMBL	AC110783	http://www.ebi.ac.uk/ena/data/view/AC110783
EMBL	AC112226	http://www.ebi.ac.uk/ena/data/view/AC112226
EMBL	AF007216	http://www.ebi.ac.uk/ena/data/view/AF007216
EMBL	AF011390	http://www.ebi.ac.uk/ena/data/view/AF011390
EMBL	AF053753	http://www.ebi.ac.uk/ena/data/view/AF053753
EMBL	AF053754	http://www.ebi.ac.uk/ena/data/view/AF053754
EMBL	AF069510	http://www.ebi.ac.uk/ena/data/view/AF069510
EMBL	AF157492	http://www.ebi.ac.uk/ena/data/view/AF157492
EMBL	AF310248	http://www.ebi.ac.uk/ena/data/view/AF310248
EMBL	BC030977	http://www.ebi.ac.uk/ena/data/view/BC030977
Ensembl	ENST00000264485	http://www.ensembl.org/id/ENST00000264485
Ensembl	ENST00000340595	http://www.ensembl.org/id/ENST00000340595
Ensembl	ENST00000351898	http://www.ensembl.org/id/ENST00000351898
Ensembl	ENST00000425175	http://www.ensembl.org/id/ENST00000425175
Ensembl	ENST00000512686	http://www.ensembl.org/id/ENST00000512686
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005452	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005452
GO_function	GO:0008510	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008510
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0015701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015701
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
Gene3D	3.40.1100.10	http://www.cathdb.info/version/latest/superfamily/3.40.1100.10
GeneCards	SLC4A4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC4A4
GeneID	8671	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8671
GeneTree	ENSGT00760000119021	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119021
HGNC	HGNC:11030	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11030
HOVERGEN	HBG004326	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004326&db=HOVERGEN
HPA	CAB022493	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB022493
HPA	HPA035628	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035628
HPA	HPA035629	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035629
InParanoid	Q9Y6R1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y6R1
IntAct	Q9Y6R1	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9Y6R1*
InterPro	IPR003020	http://www.ebi.ac.uk/interpro/entry/IPR003020
InterPro	IPR003024	http://www.ebi.ac.uk/interpro/entry/IPR003024
InterPro	IPR011531	http://www.ebi.ac.uk/interpro/entry/IPR011531
InterPro	IPR013769	http://www.ebi.ac.uk/interpro/entry/IPR013769
InterPro	IPR016152	http://www.ebi.ac.uk/interpro/entry/IPR016152
Jabion	8671	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=8671
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00429	http://www.genome.jp/dbget-bin/www_bget?H00429
KEGG_Gene	hsa:8671	http://www.genome.jp/dbget-bin/www_bget?hsa:8671
KEGG_Orthology	KO:K13575	http://www.genome.jp/dbget-bin/www_bget?KO:K13575
KEGG_Pathway	ko04964	http://www.genome.jp/kegg-bin/show_pathway?ko04964
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
MIM	603345	http://www.ncbi.nlm.nih.gov/omim/603345
MIM	604278	http://www.ncbi.nlm.nih.gov/omim/604278
OMA	VCSFMAL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VCSFMAL
Orphanet	93607	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=93607
PANTHER	PTHR11453	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11453
PRINTS	PR01231	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01231
PRINTS	PR01232	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01232
PSORT	swissprot:S4A4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S4A4_HUMAN
PSORT-B	swissprot:S4A4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S4A4_HUMAN
PSORT2	swissprot:S4A4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S4A4_HUMAN
Pfam	PF00955	http://pfam.xfam.org/family/PF00955
Pfam	PF07565	http://pfam.xfam.org/family/PF07565
PharmGKB	PA35898	http://www.pharmgkb.org/do/serve?objId=PA35898&objCls=Gene
Phobius	swissprot:S4A4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S4A4_HUMAN
PhylomeDB	Q9Y6R1	http://phylomedb.org/?seqid=Q9Y6R1
ProteinModelPortal	Q9Y6R1	http://www.proteinmodelportal.org/query/uniprot/Q9Y6R1
PubMed	10069984	http://www.ncbi.nlm.nih.gov/pubmed/10069984
PubMed	10545938	http://www.ncbi.nlm.nih.gov/pubmed/10545938
PubMed	11743927	http://www.ncbi.nlm.nih.gov/pubmed/11743927
PubMed	11744745	http://www.ncbi.nlm.nih.gov/pubmed/11744745
PubMed	12411514	http://www.ncbi.nlm.nih.gov/pubmed/12411514
PubMed	12534288	http://www.ncbi.nlm.nih.gov/pubmed/12534288
PubMed	12604466	http://www.ncbi.nlm.nih.gov/pubmed/12604466
PubMed	12730338	http://www.ncbi.nlm.nih.gov/pubmed/12730338
PubMed	12907161	http://www.ncbi.nlm.nih.gov/pubmed/12907161
PubMed	14559244	http://www.ncbi.nlm.nih.gov/pubmed/14559244
PubMed	14567693	http://www.ncbi.nlm.nih.gov/pubmed/14567693
PubMed	15218065	http://www.ncbi.nlm.nih.gov/pubmed/15218065
PubMed	15273250	http://www.ncbi.nlm.nih.gov/pubmed/15273250
PubMed	15329059	http://www.ncbi.nlm.nih.gov/pubmed/15329059
PubMed	15471865	http://www.ncbi.nlm.nih.gov/pubmed/15471865
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15563508	http://www.ncbi.nlm.nih.gov/pubmed/15563508
PubMed	15713912	http://www.ncbi.nlm.nih.gov/pubmed/15713912
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	15817634	http://www.ncbi.nlm.nih.gov/pubmed/15817634
PubMed	15930088	http://www.ncbi.nlm.nih.gov/pubmed/15930088
PubMed	16636648	http://www.ncbi.nlm.nih.gov/pubmed/16636648
PubMed	16769890	http://www.ncbi.nlm.nih.gov/pubmed/16769890
PubMed	17661077	http://www.ncbi.nlm.nih.gov/pubmed/17661077
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25568315	http://www.ncbi.nlm.nih.gov/pubmed/25568315
PubMed	9235899	http://www.ncbi.nlm.nih.gov/pubmed/9235899
PubMed	9651366	http://www.ncbi.nlm.nih.gov/pubmed/9651366
Reactome	R-HSA-425381	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425381
RefSeq	NP_001091954	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001091954
RefSeq	NP_003750	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003750
STRING	9606.ENSP00000393557	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000393557&targetmode=cogs
SUPFAM	SSF55804	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55804
TCDB	2.A.31.2.12	http://www.tcdb.org/search/result.php?tc=2.A.31.2.12
TIGRFAMs	TIGR00834	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00834
UCSC	uc003hfy	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003hfy&org=rat
UniGene	Hs.5462	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.5462
UniProtKB	S4A4_HUMAN	http://www.uniprot.org/uniprot/S4A4_HUMAN
UniProtKB-AC	Q9Y6R1	http://www.uniprot.org/uniprot/Q9Y6R1
charge	swissprot:S4A4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S4A4_HUMAN
eggNOG	ENOG410XPHD	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPHD
eggNOG	KOG1172	http://eggnogapi.embl.de/nog_data/html/tree/KOG1172
epestfind	swissprot:S4A4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S4A4_HUMAN
garnier	swissprot:S4A4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S4A4_HUMAN
helixturnhelix	swissprot:S4A4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S4A4_HUMAN
hmoment	swissprot:S4A4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S4A4_HUMAN
iep	swissprot:S4A4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S4A4_HUMAN
inforesidue	swissprot:S4A4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S4A4_HUMAN
neXtProt	NX_Q9Y6R1	http://www.nextprot.org/db/entry/NX_Q9Y6R1
octanol	swissprot:S4A4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S4A4_HUMAN
pepcoil	swissprot:S4A4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S4A4_HUMAN
pepdigest	swissprot:S4A4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S4A4_HUMAN
pepinfo	swissprot:S4A4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S4A4_HUMAN
pepnet	swissprot:S4A4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S4A4_HUMAN
pepstats	swissprot:S4A4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S4A4_HUMAN
pepwheel	swissprot:S4A4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S4A4_HUMAN
pepwindow	swissprot:S4A4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S4A4_HUMAN
sigcleave	swissprot:S4A4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S4A4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S23A2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UGH3-1; Sequence=Displayed; Name=2; IsoId=Q9UGH3-2; Sequence=VSP_056485; Note=No experimental confirmation available.; 
# AltName	S23A2_HUMAN	Na(+)/L-ascorbic acid transporter 2
# AltName	S23A2_HUMAN	Nucleobase transporter-like 1 protein
# AltName	S23A2_HUMAN	Sodium-dependent vitamin C transporter 2
# AltName	S23A2_HUMAN	Yolk sac permease-like molecule 2
# BioGrid	115287	4
# CCDS	CCDS13085	-. [Q9UGH3-1]
# ChiTaRS	SLC23A2	human
# Ensembl	ENST00000338244	ENSP00000344322; ENSG00000089057. [Q9UGH3-1]
# Ensembl	ENST00000379333	ENSP00000368637; ENSG00000089057. [Q9UGH3-1]
# ExpressionAtlas	Q9UGH3	baseline and differential
# FUNCTION	S23A2_HUMAN	Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate. 
# GO_component	GO:0005737	cytoplasm; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0009925	basal plasma membrane; IEA:Ensembl.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0016323	basolateral plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_function	GO:0008523	sodium-dependent multivitamin transmembrane transporter activity; NAS:UniProtKB.
# GO_function	GO:0015205	nucleobase transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0015229	L-ascorbic acid transporter activity; IDA:UniProtKB.
# GO_function	GO:0070890	sodium-dependent L-ascorbate transmembrane transporter activity; IDA:UniProtKB.
# GO_function	S23A2_HUMAN	GO 0008520 L-ascorbate sodium symporter activity; IEA Ensembl.
# GO_process	GO:0006139	nucleobase-containing compound metabolic process; TAS:ProtInc.
# GO_process	GO:0006979	response to oxidative stress; IEA:Ensembl.
# GO_process	GO:0015851	nucleobase transport; TAS:ProtInc.
# GO_process	GO:0015882	L-ascorbic acid transport; IDA:UniProtKB.
# GO_process	GO:0015993	molecular hydrogen transport; NAS:UniProtKB.
# GO_process	GO:0019852	L-ascorbic acid metabolic process; NAS:UniProtKB.
# GO_process	GO:0070904	transepithelial L-ascorbic acid transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0005975	carbohydrate metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# Genevisible	Q9UGH3	HS
# HGNC	HGNC:10973	SLC23A2
# InterPro	IPR006042	Xan_ur_permease
# InterPro	IPR006043	Xant/urac/vitC
# InterPro	IPR029956	SlC23A2
# KEGG_Brite	ko02001	Solute carrier family
# MIM	603791	gene
# Organism	S23A2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11119	PTHR11119
# PANTHER	PTHR11119:SF33	PTHR11119:SF33
# PIR	JC7095	JC7095
# PROSITE	PS01116	XANTH_URACIL_PERMASE
# PTM	S23A2_HUMAN	Phosphorylated. 
# Pfam	PF00860	Xan_ur_permease
# Proteomes	UP000005640	Chromosome 20
# Reactome	R-HSA-196836	Vitamin C (ascorbate) metabolism
# RecName	S23A2_HUMAN	Solute carrier family 23 member 2
# RefSeq	NP_005107	NM_005116.5. [Q9UGH3-1]
# RefSeq	NP_976072	NM_203327.1. [Q9UGH3-1]
# RefSeq	XP_011527716	XM_011529414.2. [Q9UGH3-1]
# RefSeq	XP_011527717	XM_011529415.2. [Q9UGH3-1]
# RefSeq	XP_011527718	XM_011529416.2. [Q9UGH3-1]
# RefSeq	XP_011527719	XM_011529417.2. [Q9UGH3-1]
# RefSeq	XP_016883660	XM_017028171.1. [Q9UGH3-1]
# RefSeq	XP_016883661	XM_017028172.1. [Q9UGH3-1]
# RefSeq	XP_016883662	XM_017028173.1. [Q9UGH3-1]
# RefSeq	XP_016883663	XM_017028174.1. [Q9UGH3-1]
# RefSeq	XP_016883665	XM_017028176.1. [Q9UGH3-2]
# RefSeq	XP_016883666	XM_017028177.1. [Q9UGH3-2]
# SEQUENCE CAUTION	Sequence=BAA13244.2; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S23A2_HUMAN	Cell membrane {ECO 0000269|PubMed 19379732}; Multi-pass membrane protein {ECO 0000269|PubMed 19379732}. 
# TCDB	2.A.40.6:the nucleobase/ascorbate transporter (nat) or nucleobase	cation symporter-2 (ncs2) family
# TISSUE SPECIFICITY	S23A2_HUMAN	Ubiquitous. 
# UCSC	uc002wlg	human. [Q9UGH3-1]
# eggNOG	COG2233	LUCA
# eggNOG	KOG1292	Eukaryota
BLAST	swissprot:S23A2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S23A2_HUMAN
BioCyc	ZFISH:ENSG00000089057-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000089057-MONOMER
COXPRESdb	9962	http://coxpresdb.jp/data/gene/9962.shtml
CleanEx	HS_SLC23A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC23A1
CleanEx	HS_SLC23A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC23A2
DOI	10.1006/bbrc.1999.1272	http://dx.doi.org/10.1006/bbrc.1999.1272
DOI	10.1006/geno.1999.5847	http://dx.doi.org/10.1006/geno.1999.5847
DOI	10.1016/S0014-5793(99)01393-9	http://dx.doi.org/10.1016/S0014-5793(99)01393-9
DOI	10.1016/S0167-4781(98)00151-1	http://dx.doi.org/10.1016/S0167-4781(98)00151-1
DOI	10.1016/j.yexcr.2009.04.007	http://dx.doi.org/10.1016/j.yexcr.2009.04.007
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/414865a	http://dx.doi.org/10.1038/414865a
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/dnares/3.5.321	http://dx.doi.org/10.1093/dnares/3.5.321
DOI	10.1093/dnares/9.3.99	http://dx.doi.org/10.1093/dnares/9.3.99
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
EMBL	AF058319	http://www.ebi.ac.uk/ena/data/view/AF058319
EMBL	AF092511	http://www.ebi.ac.uk/ena/data/view/AF092511
EMBL	AF164142	http://www.ebi.ac.uk/ena/data/view/AF164142
EMBL	AJ269478	http://www.ebi.ac.uk/ena/data/view/AJ269478
EMBL	AJ292318	http://www.ebi.ac.uk/ena/data/view/AJ292318
EMBL	AK296304	http://www.ebi.ac.uk/ena/data/view/AK296304
EMBL	AL109841	http://www.ebi.ac.uk/ena/data/view/AL109841
EMBL	AL121890	http://www.ebi.ac.uk/ena/data/view/AL121890
EMBL	AL389886	http://www.ebi.ac.uk/ena/data/view/AL389886
EMBL	AY380556	http://www.ebi.ac.uk/ena/data/view/AY380556
EMBL	BC013112	http://www.ebi.ac.uk/ena/data/view/BC013112
EMBL	D87075	http://www.ebi.ac.uk/ena/data/view/D87075
Ensembl	ENST00000338244	http://www.ensembl.org/id/ENST00000338244
Ensembl	ENST00000379333	http://www.ensembl.org/id/ENST00000379333
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0009925	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009925
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_function	GO:0008520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008520
GO_function	GO:0008523	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008523
GO_function	GO:0015205	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015205
GO_function	GO:0015229	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015229
GO_function	GO:0070890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070890
GO_process	GO:0006139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006139
GO_process	GO:0006979	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979
GO_process	GO:0015851	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015851
GO_process	GO:0015882	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015882
GO_process	GO:0015993	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015993
GO_process	GO:0019852	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019852
GO_process	GO:0070904	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070904
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GeneCards	SLC23A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC23A2
GeneID	9962	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9962
GeneTree	ENSGT00390000015686	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000015686
HGNC	HGNC:10973	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10973
HOGENOM	HOG000038201	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000038201&db=HOGENOM6
HOVERGEN	HBG056256	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG056256&db=HOVERGEN
HPA	HPA052825	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA052825
HPA	HPA059314	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA059314
InParanoid	Q9UGH3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UGH3
IntAct	Q9UGH3	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9UGH3*
InterPro	IPR006042	http://www.ebi.ac.uk/interpro/entry/IPR006042
InterPro	IPR006043	http://www.ebi.ac.uk/interpro/entry/IPR006043
InterPro	IPR029956	http://www.ebi.ac.uk/interpro/entry/IPR029956
Jabion	9962	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9962
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:9962	http://www.genome.jp/dbget-bin/www_bget?hsa:9962
KEGG_Orthology	KO:K14611	http://www.genome.jp/dbget-bin/www_bget?KO:K14611
MIM	603791	http://www.ncbi.nlm.nih.gov/omim/603791
OMA	IGMEGLM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IGMEGLM
OrthoDB	EOG091G063Y	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G063Y
PANTHER	PTHR11119	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11119
PANTHER	PTHR11119:SF33	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11119:SF33
PROSITE	PS01116	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01116
PSORT	swissprot:S23A2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S23A2_HUMAN
PSORT-B	swissprot:S23A2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S23A2_HUMAN
PSORT2	swissprot:S23A2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S23A2_HUMAN
Pfam	PF00860	http://pfam.xfam.org/family/PF00860
PharmGKB	PA35849	http://www.pharmgkb.org/do/serve?objId=PA35849&objCls=Gene
Phobius	swissprot:S23A2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S23A2_HUMAN
PhylomeDB	Q9UGH3	http://phylomedb.org/?seqid=Q9UGH3
ProteinModelPortal	Q9UGH3	http://www.proteinmodelportal.org/query/uniprot/Q9UGH3
PubMed	10395795	http://www.ncbi.nlm.nih.gov/pubmed/10395795
PubMed	10471399	http://www.ncbi.nlm.nih.gov/pubmed/10471399
PubMed	10556521	http://www.ncbi.nlm.nih.gov/pubmed/10556521
PubMed	11396616	http://www.ncbi.nlm.nih.gov/pubmed/11396616
PubMed	11780052	http://www.ncbi.nlm.nih.gov/pubmed/11780052
PubMed	12168954	http://www.ncbi.nlm.nih.gov/pubmed/12168954
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19379732	http://www.ncbi.nlm.nih.gov/pubmed/19379732
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	9039502	http://www.ncbi.nlm.nih.gov/pubmed/9039502
PubMed	9804989	http://www.ncbi.nlm.nih.gov/pubmed/9804989
Reactome	R-HSA-196836	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-196836
RefSeq	NP_005107	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005107
RefSeq	NP_976072	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_976072
RefSeq	XP_011527716	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011527716
RefSeq	XP_011527717	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011527717
RefSeq	XP_011527718	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011527718
RefSeq	XP_011527719	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011527719
RefSeq	XP_016883660	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016883660
RefSeq	XP_016883661	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016883661
RefSeq	XP_016883662	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016883662
RefSeq	XP_016883663	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016883663
RefSeq	XP_016883665	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016883665
RefSeq	XP_016883666	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016883666
STRING	9606.ENSP00000344322	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000344322&targetmode=cogs
TCDB	2.A.40.6	http://www.tcdb.org/search/result.php?tc=2.A.40.6
UCSC	uc002wlg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002wlg&org=rat
UniGene	Hs.516866	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.516866
UniProtKB	S23A2_HUMAN	http://www.uniprot.org/uniprot/S23A2_HUMAN
UniProtKB-AC	Q9UGH3	http://www.uniprot.org/uniprot/Q9UGH3
charge	swissprot:S23A2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S23A2_HUMAN
eggNOG	COG2233	http://eggnogapi.embl.de/nog_data/html/tree/COG2233
eggNOG	KOG1292	http://eggnogapi.embl.de/nog_data/html/tree/KOG1292
epestfind	swissprot:S23A2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S23A2_HUMAN
garnier	swissprot:S23A2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S23A2_HUMAN
helixturnhelix	swissprot:S23A2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S23A2_HUMAN
hmoment	swissprot:S23A2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S23A2_HUMAN
iep	swissprot:S23A2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S23A2_HUMAN
inforesidue	swissprot:S23A2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S23A2_HUMAN
neXtProt	NX_Q9UGH3	http://www.nextprot.org/db/entry/NX_Q9UGH3
octanol	swissprot:S23A2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S23A2_HUMAN
pepcoil	swissprot:S23A2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S23A2_HUMAN
pepdigest	swissprot:S23A2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S23A2_HUMAN
pepinfo	swissprot:S23A2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S23A2_HUMAN
pepnet	swissprot:S23A2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S23A2_HUMAN
pepstats	swissprot:S23A2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S23A2_HUMAN
pepwheel	swissprot:S23A2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S23A2_HUMAN
pepwindow	swissprot:S23A2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S23A2_HUMAN
sigcleave	swissprot:S23A2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S23A2_HUMAN
## Database	ID	URL or Descriptions
# CDD	cd06174	MFS
# Ensembl	ENST00000326192	ENSP00000321549; ENSG00000197658
# ExpressionAtlas	Q8N4F4	baseline and differential
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0005452	inorganic anion exchanger activity; IBA:GO_Central.
# GO_function	GO:0015347	sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0043252	sodium-independent organic anion transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q8N4F4	HS
# HGNC	HGNC:28542	SLC22A24
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	611698	gene
# Organism	S22AO_HUMAN	Homo sapiens (Human)
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 11
# RecName	S22AO_HUMAN	Solute carrier family 22 member 24
# RefSeq	NP_775857	NM_173586.2
# SIMILARITY	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S22AO_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF103473	SSF103473
# UCSC	uc010rmn	human
# eggNOG	COG0477	LUCA
# eggNOG	KOG0255	Eukaryota
BLAST	swissprot:S22AO_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S22AO_HUMAN
BioCyc	ZFISH:ENSG00000176642-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000176642-MONOMER
COXPRESdb	283238	http://coxpresdb.jp/data/gene/283238.shtml
CleanEx	HS_SLC22A24	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC22A24
DOI	10.1016/j.ygeno.2007.03.017	http://dx.doi.org/10.1016/j.ygeno.2007.03.017
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	BC034394	http://www.ebi.ac.uk/ena/data/view/BC034394
Ensembl	ENST00000326192	http://www.ensembl.org/id/ENST00000326192
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005452	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005452
GO_function	GO:0015347	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015347
GO_process	GO:0043252	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043252
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC22A24	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC22A24
GeneID	283238	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=283238
H-InvDB	HIX0009734	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0009734
HGNC	HGNC:28542	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:28542
HOGENOM	HOG000234569	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234569&db=HOGENOM6
HOVERGEN	HBG108433	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108433&db=HOVERGEN
HPA	HPA045015	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA045015
InParanoid	Q8N4F4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8N4F4
IntAct	Q8N4F4	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8N4F4*
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	283238	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=283238
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:283238	http://www.genome.jp/dbget-bin/www_bget?hsa:283238
KEGG_Orthology	KO:K08206	http://www.genome.jp/dbget-bin/www_bget?KO:K08206
MIM	611698	http://www.ncbi.nlm.nih.gov/omim/611698
MINT	MINT-1451757	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1451757
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:S22AO_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S22AO_HUMAN
PSORT-B	swissprot:S22AO_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S22AO_HUMAN
PSORT2	swissprot:S22AO_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S22AO_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
Phobius	swissprot:S22AO_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S22AO_HUMAN
PhylomeDB	Q8N4F4	http://phylomedb.org/?seqid=Q8N4F4
ProteinModelPortal	Q8N4F4	http://www.proteinmodelportal.org/query/uniprot/Q8N4F4
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17714910	http://www.ncbi.nlm.nih.gov/pubmed/17714910
RefSeq	NP_775857	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_775857
STRING	9606.ENSP00000396586	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000396586&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
UCSC	uc010rmn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010rmn&org=rat
UniGene	Hs.375139	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.375139
UniProtKB	S22AO_HUMAN	http://www.uniprot.org/uniprot/S22AO_HUMAN
UniProtKB-AC	Q8N4F4	http://www.uniprot.org/uniprot/Q8N4F4
charge	swissprot:S22AO_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S22AO_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG0255	http://eggnogapi.embl.de/nog_data/html/tree/KOG0255
epestfind	swissprot:S22AO_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S22AO_HUMAN
garnier	swissprot:S22AO_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S22AO_HUMAN
helixturnhelix	swissprot:S22AO_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S22AO_HUMAN
hmoment	swissprot:S22AO_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S22AO_HUMAN
iep	swissprot:S22AO_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S22AO_HUMAN
inforesidue	swissprot:S22AO_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S22AO_HUMAN
neXtProt	NX_Q8N4F4	http://www.nextprot.org/db/entry/NX_Q8N4F4
octanol	swissprot:S22AO_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S22AO_HUMAN
pepcoil	swissprot:S22AO_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S22AO_HUMAN
pepdigest	swissprot:S22AO_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S22AO_HUMAN
pepinfo	swissprot:S22AO_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S22AO_HUMAN
pepnet	swissprot:S22AO_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S22AO_HUMAN
pepstats	swissprot:S22AO_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S22AO_HUMAN
pepwheel	swissprot:S22AO_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S22AO_HUMAN
pepwindow	swissprot:S22AO_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S22AO_HUMAN
sigcleave	swissprot:S22AO_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S22AO_HUMAN
## Database	ID	URL or Descriptions
# AltName	CLIC2_HUMAN	XAP121
# BioGrid	107605	6
# DISEASE	CLIC2_HUMAN	Mental retardation, X-linked, syndromic, 32 (MRXS32) [MIM 300886]  A mental retardation syndrome characterized by profound intellectual deficit, delayed psychomotor development beginning in infancy and little or no speech development. Additional features include seizures, large joint contractures, and abnormal positioning of the thumbs. Mental retardation is defined by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO 0000269|PubMed 22814392}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	CLIC2_HUMAN	Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion. 
# Ensembl	ENST00000369449	ENSP00000358460; ENSG00000155962
# ExpressionAtlas	O15247	baseline and differential
# FUNCTION	CLIC2_HUMAN	Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx. {ECO 0000269|PubMed 15147738, ECO 0000269|PubMed 15916532, ECO 0000269|PubMed 17945253}. 
# GO_component	GO:0005622	intracellular; IDA:LIFEdb.
# GO_component	GO:0005634	nucleus; TAS:UniProtKB.
# GO_component	GO:0005737	cytoplasm; TAS:UniProtKB.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_function	GO:0004602	glutathione peroxidase activity; IDA:BHF-UCL.
# GO_function	GO:0005244	voltage-gated ion channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0005254	chloride channel activity; TAS:ProtInc.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007165	signal transduction; TAS:UniProtKB.
# GO_process	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IDA:BHF-UCL.
# GO_process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; IC:BHF-UCL.
# GO_process	GO:0051099	positive regulation of binding; IDA:BHF-UCL.
# GO_process	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity; IDA:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005622	intracellular
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005737	cytoplasm
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.20.1050.10	-; 1.
# Gene3D	3.40.30.10	-; 1.
# Genevisible	O15247	HS
# HGNC	HGNC:2063	CLIC2
# InterPro	IPR002946	CLIC
# InterPro	IPR004045	Glutathione_S-Trfase_N
# InterPro	IPR010987	Glutathione-S-Trfase_C-like
# InterPro	IPR012336	Thioredoxin-like_fold
# InterPro	IPR030253	CLIC-2
# KEGG_Brite	ko04040	Ion channels
# MIM	300138	gene
# MIM	300886	phenotype
# Organism	CLIC2_HUMAN	Homo sapiens (Human)
# Orphanet	324410	X-linked intellectual disability - cardiomegaly - congestive heart failure
# PANTHER	PTHR11260:SF133	PTHR11260:SF133; 2
# PDB	2PER	X-ray; 2.00 A; A=1-247
# PDB	2R4V	X-ray; 1.85 A; A=1-247
# PDB	2R5G	X-ray; 1.86 A; A=1-247
# PRINTS	PR01263	INTCLCHANNEL
# PROSITE	PS50405	GST_CTER
# Pfam	PF13409	GST_N_2
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# Reactome	R-HSA-5578775	Ion homeostasis
# RecName	CLIC2_HUMAN	Chloride intracellular channel protein 2
# RefSeq	NP_001280	NM_001289.5
# SEQUENCE CAUTION	Sequence=CAA73228.1; Type=Frameshift; Positions=244; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the chloride channel CLIC family. {ECO	0000305}. 
# SIMILARITY	Contains 1 GST C-terminal domain. {ECO	0000305}. 
# SUBCELLULAR LOCATION	CLIC2_HUMAN	Cytoplasm {ECO 0000269|PubMed 15916532}. Membrane {ECO 0000305|PubMed 15916532}; Single-pass membrane protein {ECO 0000305|PubMed 15916532}. Note=Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. 
# SUBUNIT	CLIC2_HUMAN	Monomer. Interacts with TRAPPC2 and RYR2. {ECO 0000269|PubMed 12681486, ECO 0000269|PubMed 15147738, ECO 0000269|PubMed 15916532, ECO 0000269|PubMed 17945253}. 
# SUPFAM	SSF47616	SSF47616
# SUPFAM	SSF52833	SSF52833
# TCDB	1.A.12.1	the intracellular chloride channel (clic) family
# TIGRFAMs	TIGR00862	O-ClC
# TISSUE SPECIFICITY	CLIC2_HUMAN	Expressed in adult and fetal brain, heart, skeletal muscle, liver, lung, and spleen. Detected in adult stomach and testis. Expressed in fetal thymus and kidney. {ECO 0000269|PubMed 15147738, ECO 0000269|PubMed 22814392}. 
# UCSC	uc004fnf	human
# eggNOG	ENOG410ZRK6	LUCA
# eggNOG	KOG1422	Eukaryota
BLAST	swissprot:CLIC2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CLIC2_HUMAN
BioCyc	ZFISH:ENSG00000155962-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000155962-MONOMER
COXPRESdb	1193	http://coxpresdb.jp/data/gene/1193.shtml
CleanEx	HS_CLIC2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CLIC2
DOI	10.1002/prot.21922	http://dx.doi.org/10.1002/prot.21922
DOI	10.1006/geno.1997.4922	http://dx.doi.org/10.1006/geno.1997.4922
DOI	10.1016/S0014-5793(03)00228-X	http://dx.doi.org/10.1016/S0014-5793(03)00228-X
DOI	10.1016/j.biocel.2004.01.026	http://dx.doi.org/10.1016/j.biocel.2004.01.026
DOI	10.1016/j.jmb.2007.09.041	http://dx.doi.org/10.1016/j.jmb.2007.09.041
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/BJ20042113	http://dx.doi.org/10.1042/BJ20042113
DOI	10.1093/hmg/dds292	http://dx.doi.org/10.1093/hmg/dds292
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AJ000217	http://www.ebi.ac.uk/ena/data/view/AJ000217
EMBL	AJ000218	http://www.ebi.ac.uk/ena/data/view/AJ000218
EMBL	AJ000219	http://www.ebi.ac.uk/ena/data/view/AJ000219
EMBL	AK292785	http://www.ebi.ac.uk/ena/data/view/AK292785
EMBL	AL356738	http://www.ebi.ac.uk/ena/data/view/AL356738
EMBL	BC022305	http://www.ebi.ac.uk/ena/data/view/BC022305
EMBL	CH471172	http://www.ebi.ac.uk/ena/data/view/CH471172
EMBL	Y12696	http://www.ebi.ac.uk/ena/data/view/Y12696
Ensembl	ENST00000369449	http://www.ensembl.org/id/ENST00000369449
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_function	GO:0004602	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004602
GO_function	GO:0005244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005244
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0010880	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010880
GO_process	GO:0010881	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010881
GO_process	GO:0051099	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051099
GO_process	GO:0060315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060315
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.20.1050.10	http://www.cathdb.info/version/latest/superfamily/1.20.1050.10
Gene3D	3.40.30.10	http://www.cathdb.info/version/latest/superfamily/3.40.30.10
GeneCards	CLIC2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CLIC2
GeneID	1193	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1193
GeneTree	ENSGT00550000074477	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074477
HGNC	HGNC:2063	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2063
HOGENOM	HOG000231548	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231548&db=HOGENOM6
HOVERGEN	HBG050994	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050994&db=HOVERGEN
HPA	HPA060101	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA060101
InParanoid	O15247	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O15247
IntAct	O15247	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O15247*
InterPro	IPR002946	http://www.ebi.ac.uk/interpro/entry/IPR002946
InterPro	IPR004045	http://www.ebi.ac.uk/interpro/entry/IPR004045
InterPro	IPR010987	http://www.ebi.ac.uk/interpro/entry/IPR010987
InterPro	IPR012336	http://www.ebi.ac.uk/interpro/entry/IPR012336
InterPro	IPR030253	http://www.ebi.ac.uk/interpro/entry/IPR030253
Jabion	1193	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1193
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:1193	http://www.genome.jp/dbget-bin/www_bget?hsa:1193
KEGG_Orthology	KO:K05022	http://www.genome.jp/dbget-bin/www_bget?KO:K05022
MIM	300138	http://www.ncbi.nlm.nih.gov/omim/300138
MIM	300886	http://www.ncbi.nlm.nih.gov/omim/300886
MINT	MINT-4713986	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4713986
OMA	SYMKSIF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SYMKSIF
Orphanet	324410	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=324410
OrthoDB	EOG091G0IHT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0IHT
PANTHER	PTHR11260:SF133	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11260:SF133
PDB	2PER	http://www.ebi.ac.uk/pdbe-srv/view/entry/2PER
PDB	2R4V	http://www.ebi.ac.uk/pdbe-srv/view/entry/2R4V
PDB	2R5G	http://www.ebi.ac.uk/pdbe-srv/view/entry/2R5G
PDBsum	2PER	http://www.ebi.ac.uk/pdbsum/2PER
PDBsum	2R4V	http://www.ebi.ac.uk/pdbsum/2R4V
PDBsum	2R5G	http://www.ebi.ac.uk/pdbsum/2R5G
PRINTS	PR01263	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01263
PROSITE	PS50405	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50405
PSORT	swissprot:CLIC2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CLIC2_HUMAN
PSORT-B	swissprot:CLIC2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CLIC2_HUMAN
PSORT2	swissprot:CLIC2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CLIC2_HUMAN
Pfam	PF13409	http://pfam.xfam.org/family/PF13409
PharmGKB	PA26589	http://www.pharmgkb.org/do/serve?objId=PA26589&objCls=Gene
Phobius	swissprot:CLIC2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CLIC2_HUMAN
PhylomeDB	O15247	http://phylomedb.org/?seqid=O15247
ProteinModelPortal	O15247	http://www.proteinmodelportal.org/query/uniprot/O15247
PubMed	12681486	http://www.ncbi.nlm.nih.gov/pubmed/12681486
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15147738	http://www.ncbi.nlm.nih.gov/pubmed/15147738
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	15916532	http://www.ncbi.nlm.nih.gov/pubmed/15916532
PubMed	17945253	http://www.ncbi.nlm.nih.gov/pubmed/17945253
PubMed	18186468	http://www.ncbi.nlm.nih.gov/pubmed/18186468
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22814392	http://www.ncbi.nlm.nih.gov/pubmed/22814392
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	9339381	http://www.ncbi.nlm.nih.gov/pubmed/9339381
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
RefSeq	NP_001280	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001280
SMR	O15247	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O15247
STRING	9606.ENSP00000358460	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000358460&targetmode=cogs
SUPFAM	SSF47616	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47616
SUPFAM	SSF52833	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833
TCDB	1.A.12.1	http://www.tcdb.org/search/result.php?tc=1.A.12.1
TIGRFAMs	TIGR00862	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00862
UCSC	uc004fnf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004fnf&org=rat
UniGene	Hs.655445	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.655445
UniProtKB	CLIC2_HUMAN	http://www.uniprot.org/uniprot/CLIC2_HUMAN
UniProtKB-AC	O15247	http://www.uniprot.org/uniprot/O15247
charge	swissprot:CLIC2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CLIC2_HUMAN
eggNOG	ENOG410ZRK6	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZRK6
eggNOG	KOG1422	http://eggnogapi.embl.de/nog_data/html/tree/KOG1422
epestfind	swissprot:CLIC2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CLIC2_HUMAN
garnier	swissprot:CLIC2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CLIC2_HUMAN
helixturnhelix	swissprot:CLIC2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLIC2_HUMAN
hmoment	swissprot:CLIC2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CLIC2_HUMAN
iep	swissprot:CLIC2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CLIC2_HUMAN
inforesidue	swissprot:CLIC2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CLIC2_HUMAN
neXtProt	NX_O15247	http://www.nextprot.org/db/entry/NX_O15247
octanol	swissprot:CLIC2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CLIC2_HUMAN
pepcoil	swissprot:CLIC2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CLIC2_HUMAN
pepdigest	swissprot:CLIC2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CLIC2_HUMAN
pepinfo	swissprot:CLIC2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CLIC2_HUMAN
pepnet	swissprot:CLIC2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CLIC2_HUMAN
pepstats	swissprot:CLIC2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CLIC2_HUMAN
pepwheel	swissprot:CLIC2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CLIC2_HUMAN
pepwindow	swissprot:CLIC2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CLIC2_HUMAN
sigcleave	swissprot:CLIC2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CLIC2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S7A13_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8TCU3-1; Sequence=Displayed; Name=2; IsoId=Q8TCU3-2; Sequence=VSP_033067, VSP_033068, VSP_033069; 
# AltName	S7A13_HUMAN	Sodium-independent aspartate/glutamate transporter 1
# AltName	S7A13_HUMAN	X-amino acid transporter 2
# CCDS	CCDS34917	-. [Q8TCU3-1]
# Ensembl	ENST00000297524	ENSP00000297524; ENSG00000164893. [Q8TCU3-1]
# Ensembl	ENST00000419776	ENSP00000410982; ENSG00000164893. [Q8TCU3-2]
# FUNCTION	S7A13_HUMAN	Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner. {ECO 0000250}. 
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0015175	neutral amino acid transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015179	L-amino acid transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015297	antiporter activity; IBA:GO_Central.
# GO_process	GO:0015804	neutral amino acid transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q8TCU3	HS
# HGNC	HGNC:23092	SLC7A13
# InterPro	IPR002293	AA/rel_permease1
# KEGG_Brite	ko02001	Solute carrier family
# Organism	S7A13_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11785	PTHR11785
# PIRSF	PIRSF006060	AA_transporter
# Pfam	PF13520	AA_permease_2
# Proteomes	UP000005640	Chromosome 8
# RecName	S7A13_HUMAN	Solute carrier family 7 member 13
# RefSeq	NP_620172	NM_138817.2. [Q8TCU3-1]
# SIMILARITY	Belongs to the amino acid-polyamine-organocation (APC) superfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	S7A13_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	2.A.3.8.24	the amino acid-polyamine-organocation (apc) family
# TISSUE SPECIFICITY	Expressed in the kidney. {ECO:0000269|PubMed	11943479}. 
# UCSC	uc003ydq	human. [Q8TCU3-1]
# eggNOG	COG0531	LUCA
# eggNOG	KOG1287	Eukaryota
BLAST	swissprot:S7A13_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S7A13_HUMAN
BioCyc	ZFISH:ENSG00000164893-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000164893-MONOMER
COXPRESdb	157724	http://coxpresdb.jp/data/gene/157724.shtml
CleanEx	HS_SLC7A13	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC7A13
DOI	10.1016/S0378-1119(02)00435-3	http://dx.doi.org/10.1016/S0378-1119(02)00435-3
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AJ417661	http://www.ebi.ac.uk/ena/data/view/AJ417661
EMBL	AK055815	http://www.ebi.ac.uk/ena/data/view/AK055815
EMBL	BC029436	http://www.ebi.ac.uk/ena/data/view/BC029436
EMBL	BC125165	http://www.ebi.ac.uk/ena/data/view/BC125165
EMBL	BC125166	http://www.ebi.ac.uk/ena/data/view/BC125166
EMBL	CH471060	http://www.ebi.ac.uk/ena/data/view/CH471060
Ensembl	ENST00000297524	http://www.ensembl.org/id/ENST00000297524
Ensembl	ENST00000419776	http://www.ensembl.org/id/ENST00000419776
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0015175	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015175
GO_function	GO:0015179	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015179
GO_function	GO:0015297	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297
GO_process	GO:0015804	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015804
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC7A13	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC7A13
GeneID	157724	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=157724
GeneTree	ENSGT00760000119037	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119037
H-InvDB	HIX0007630	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0007630
HGNC	HGNC:23092	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:23092
HOGENOM	HOG000098892	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000098892&db=HOGENOM6
HOVERGEN	HBG000476	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000476&db=HOVERGEN
InParanoid	Q8TCU3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8TCU3
InterPro	IPR002293	http://www.ebi.ac.uk/interpro/entry/IPR002293
Jabion	157724	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=157724
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:157724	http://www.genome.jp/dbget-bin/www_bget?hsa:157724
KEGG_Orthology	KO:K13870	http://www.genome.jp/dbget-bin/www_bget?KO:K13870
OMA	CSAEISI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CSAEISI
OrthoDB	EOG091G05K3	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05K3
PANTHER	PTHR11785	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785
PSORT	swissprot:S7A13_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S7A13_HUMAN
PSORT-B	swissprot:S7A13_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S7A13_HUMAN
PSORT2	swissprot:S7A13_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S7A13_HUMAN
Pfam	PF13520	http://pfam.xfam.org/family/PF13520
PharmGKB	PA134980828	http://www.pharmgkb.org/do/serve?objId=PA134980828&objCls=Gene
Phobius	swissprot:S7A13_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S7A13_HUMAN
PhylomeDB	Q8TCU3	http://phylomedb.org/?seqid=Q8TCU3
ProteinModelPortal	Q8TCU3	http://www.proteinmodelportal.org/query/uniprot/Q8TCU3
PubMed	11943479	http://www.ncbi.nlm.nih.gov/pubmed/11943479
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
RefSeq	NP_620172	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_620172
STRING	9606.ENSP00000297524	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000297524&targetmode=cogs
TCDB	2.A.3.8.24	http://www.tcdb.org/search/result.php?tc=2.A.3.8.24
UCSC	uc003ydq	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ydq&org=rat
UniGene	Hs.149095	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.149095
UniProtKB	S7A13_HUMAN	http://www.uniprot.org/uniprot/S7A13_HUMAN
UniProtKB-AC	Q8TCU3	http://www.uniprot.org/uniprot/Q8TCU3
charge	swissprot:S7A13_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S7A13_HUMAN
eggNOG	COG0531	http://eggnogapi.embl.de/nog_data/html/tree/COG0531
eggNOG	KOG1287	http://eggnogapi.embl.de/nog_data/html/tree/KOG1287
epestfind	swissprot:S7A13_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S7A13_HUMAN
garnier	swissprot:S7A13_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S7A13_HUMAN
helixturnhelix	swissprot:S7A13_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S7A13_HUMAN
hmoment	swissprot:S7A13_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S7A13_HUMAN
iep	swissprot:S7A13_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S7A13_HUMAN
inforesidue	swissprot:S7A13_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S7A13_HUMAN
neXtProt	NX_Q8TCU3	http://www.nextprot.org/db/entry/NX_Q8TCU3
octanol	swissprot:S7A13_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S7A13_HUMAN
pepcoil	swissprot:S7A13_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S7A13_HUMAN
pepdigest	swissprot:S7A13_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S7A13_HUMAN
pepinfo	swissprot:S7A13_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S7A13_HUMAN
pepnet	swissprot:S7A13_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S7A13_HUMAN
pepstats	swissprot:S7A13_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S7A13_HUMAN
pepwheel	swissprot:S7A13_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S7A13_HUMAN
pepwindow	swissprot:S7A13_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S7A13_HUMAN
sigcleave	swissprot:S7A13_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S7A13_HUMAN
## Database	ID	URL or Descriptions
# AltName	TM38B_HUMAN	Transmembrane protein 38B
# BioGrid	120454	8
# ChiTaRS	TMEM38B	human
# DISEASE	TM38B_HUMAN	Osteogenesis imperfecta 14 (OI14) [MIM 615066]  An autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI14 is characterized by variable degrees of severity of multiple fractures and osteopenia, with normal teeth, sclerae, and hearing. Fractures first occur prenatally or by age 6 years. {ECO 0000269|PubMed 23054245, ECO 0000269|PubMed 23316006}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	TM38B_HUMAN	The second transmembrane domain has been proposed to cross only half of the lipid bilayer and to loop back into the cytosol, so that the domains on each side of this domain are both found on the cytosolic face of the membrane. The cytosolic loop may form an ion-conducting pore (By similarity). {ECO 0000250}. 
# Ensembl	ENST00000374692	ENSP00000363824; ENSG00000095209
# ExpressionAtlas	Q9NVV0	baseline and differential
# FUNCTION	TM38B_HUMAN	Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity). {ECO 0000250}. 
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0031965	nuclear membrane; NAS:BHF-UCL.
# GO_component	GO:0033017	sarcoplasmic reticulum membrane; NAS:BHF-UCL.
# GO_function	GO:0005267	potassium channel activity; TAS:BHF-UCL.
# GO_function	GO:0015269	calcium-activated potassium channel activity; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_function	GO:0022857	transmembrane transporter activity
# Genevisible	Q9NVV0	HS
# HGNC	HGNC:25535	TMEM38B
# IntAct	Q9NVV0	4
# InterPro	IPR007866	TRIC_channel
# MIM	611236	gene
# MIM	615066	phenotype
# Organism	TM38B_HUMAN	Homo sapiens (Human)
# Orphanet	216820	Osteogenesis imperfecta type 4
# PANTHER	PTHR12454	PTHR12454
# Pfam	PF05197	TRIC
# Proteomes	UP000005640	Chromosome 9
# RecName	TM38B_HUMAN	Trimeric intracellular cation channel type B
# RefSeq	NP_060582	NM_018112.2
# SEQUENCE CAUTION	TM38B_HUMAN	Sequence=CAH71458.1; Type=Erroneous gene model prediction; Evidence={ECO 0000305}; Sequence=CAI12390.1; Type=Erroneous gene model prediction; Evidence={ECO 0000305}; Sequence=CAI12391.1; Type=Erroneous gene model prediction; Evidence={ECO 0000305}; Sequence=CAI12392.1; Type=Erroneous gene model prediction; Evidence={ECO 0000305}; Sequence=CAI39690.1; Type=Erroneous initiation; Evidence={ECO 0000305}; Sequence=CAI39691.1; Type=Erroneous gene model prediction; Evidence={ECO 0000305}; Sequence=CAI39692.1; Type=Erroneous gene model prediction; Evidence={ECO 0000305};
# SIMILARITY	Belongs to the TMEM38 family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	TM38B_HUMAN	Endoplasmic reticulum membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUBUNIT	Homotrimer. {ECO	0000250}. 
# TCDB	1.A.62.1	the homotrimeric cation channel (tric) family
# UCSC	uc004bcu	human
# eggNOG	ENOG410XQ0P	LUCA
# eggNOG	KOG3944	Eukaryota
BLAST	swissprot:TM38B_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TM38B_HUMAN
BioCyc	ZFISH:ENSG00000095209-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000095209-MONOMER
COXPRESdb	55151	http://coxpresdb.jp/data/gene/55151.shtml
CleanEx	HS_TMEM38B	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TMEM38B
DOI	10.1002/humu.22274	http://dx.doi.org/10.1002/humu.22274
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1136/jmedgenet-2012-101142	http://dx.doi.org/10.1136/jmedgenet-2012-101142
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AK001355	http://www.ebi.ac.uk/ena/data/view/AK001355
EMBL	AL592437	http://www.ebi.ac.uk/ena/data/view/AL592437
EMBL	AL592437	http://www.ebi.ac.uk/ena/data/view/AL592437
EMBL	AL592437	http://www.ebi.ac.uk/ena/data/view/AL592437
EMBL	AL592437	http://www.ebi.ac.uk/ena/data/view/AL592437
EMBL	AL592437	http://www.ebi.ac.uk/ena/data/view/AL592437
EMBL	AL592437	http://www.ebi.ac.uk/ena/data/view/AL592437
EMBL	AL592437	http://www.ebi.ac.uk/ena/data/view/AL592437
EMBL	AL592437	http://www.ebi.ac.uk/ena/data/view/AL592437
EMBL	AL592437	http://www.ebi.ac.uk/ena/data/view/AL592437
EMBL	AL592488	http://www.ebi.ac.uk/ena/data/view/AL592488
EMBL	AL592488	http://www.ebi.ac.uk/ena/data/view/AL592488
EMBL	AL592488	http://www.ebi.ac.uk/ena/data/view/AL592488
EMBL	AL592488	http://www.ebi.ac.uk/ena/data/view/AL592488
EMBL	AL592488	http://www.ebi.ac.uk/ena/data/view/AL592488
EMBL	AL592488	http://www.ebi.ac.uk/ena/data/view/AL592488
EMBL	AL627247	http://www.ebi.ac.uk/ena/data/view/AL627247
EMBL	AL627247	http://www.ebi.ac.uk/ena/data/view/AL627247
EMBL	AL627247	http://www.ebi.ac.uk/ena/data/view/AL627247
EMBL	AL627247	http://www.ebi.ac.uk/ena/data/view/AL627247
EMBL	AL627247	http://www.ebi.ac.uk/ena/data/view/AL627247
EMBL	AL627247	http://www.ebi.ac.uk/ena/data/view/AL627247
EMBL	AL627247	http://www.ebi.ac.uk/ena/data/view/AL627247
EMBL	AL627247	http://www.ebi.ac.uk/ena/data/view/AL627247
EMBL	AL627247	http://www.ebi.ac.uk/ena/data/view/AL627247
EMBL	BC000049	http://www.ebi.ac.uk/ena/data/view/BC000049
EMBL	CR457258	http://www.ebi.ac.uk/ena/data/view/CR457258
Ensembl	ENST00000374692	http://www.ensembl.org/id/ENST00000374692
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0031965	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031965
GO_component	GO:0033017	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033017
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_function	GO:0015269	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015269
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GeneCards	TMEM38B	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TMEM38B
GeneID	55151	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55151
GeneTree	ENSGT00390000018845	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000018845
HGNC	HGNC:25535	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:25535
HOGENOM	HOG000037929	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000037929&db=HOGENOM6
HOVERGEN	HBG059853	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG059853&db=HOVERGEN
HPA	HPA018465	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA018465
InParanoid	Q9NVV0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NVV0
IntAct	Q9NVV0	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NVV0*
InterPro	IPR007866	http://www.ebi.ac.uk/interpro/entry/IPR007866
Jabion	55151	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55151
KEGG_Gene	hsa:55151	http://www.genome.jp/dbget-bin/www_bget?hsa:55151
MIM	611236	http://www.ncbi.nlm.nih.gov/omim/611236
MIM	615066	http://www.ncbi.nlm.nih.gov/omim/615066
OMA	KMSYPSK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KMSYPSK
Orphanet	216820	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=216820
OrthoDB	EOG091G0GQP	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0GQP
PANTHER	PTHR12454	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12454
PSORT	swissprot:TM38B_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TM38B_HUMAN
PSORT-B	swissprot:TM38B_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TM38B_HUMAN
PSORT2	swissprot:TM38B_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TM38B_HUMAN
Pfam	PF05197	http://pfam.xfam.org/family/PF05197
PharmGKB	PA134916126	http://www.pharmgkb.org/do/serve?objId=PA134916126&objCls=Gene
Phobius	swissprot:TM38B_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TM38B_HUMAN
PhylomeDB	Q9NVV0	http://phylomedb.org/?seqid=Q9NVV0
ProteinModelPortal	Q9NVV0	http://www.proteinmodelportal.org/query/uniprot/Q9NVV0
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23054245	http://www.ncbi.nlm.nih.gov/pubmed/23054245
PubMed	23316006	http://www.ncbi.nlm.nih.gov/pubmed/23316006
RefSeq	NP_060582	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060582
STRING	9606.ENSP00000363824	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000363824&targetmode=cogs
TCDB	1.A.62.1	http://www.tcdb.org/search/result.php?tc=1.A.62.1
UCSC	uc004bcu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004bcu&org=rat
UniGene	Hs.411925	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.411925
UniGene	Hs.618078	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.618078
UniProtKB	TM38B_HUMAN	http://www.uniprot.org/uniprot/TM38B_HUMAN
UniProtKB-AC	Q9NVV0	http://www.uniprot.org/uniprot/Q9NVV0
charge	swissprot:TM38B_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TM38B_HUMAN
eggNOG	ENOG410XQ0P	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ0P
eggNOG	KOG3944	http://eggnogapi.embl.de/nog_data/html/tree/KOG3944
epestfind	swissprot:TM38B_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TM38B_HUMAN
garnier	swissprot:TM38B_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TM38B_HUMAN
helixturnhelix	swissprot:TM38B_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TM38B_HUMAN
hmoment	swissprot:TM38B_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TM38B_HUMAN
iep	swissprot:TM38B_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TM38B_HUMAN
inforesidue	swissprot:TM38B_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TM38B_HUMAN
neXtProt	NX_Q9NVV0	http://www.nextprot.org/db/entry/NX_Q9NVV0
octanol	swissprot:TM38B_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TM38B_HUMAN
pepcoil	swissprot:TM38B_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TM38B_HUMAN
pepdigest	swissprot:TM38B_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TM38B_HUMAN
pepinfo	swissprot:TM38B_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TM38B_HUMAN
pepnet	swissprot:TM38B_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TM38B_HUMAN
pepstats	swissprot:TM38B_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TM38B_HUMAN
pepwheel	swissprot:TM38B_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TM38B_HUMAN
pepwindow	swissprot:TM38B_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TM38B_HUMAN
sigcleave	swissprot:TM38B_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TM38B_HUMAN
## Database	ID	URL or Descriptions
# AltName	S22A3_HUMAN	Extraneuronal monoamine transporter
# AltName	S22A3_HUMAN	Organic cation transporter 3
# CDD	cd06174	MFS
# ChiTaRS	SLC22A3	human
# DrugBank	DB00122	Choline
# DrugBank	DB00182	Amphetamine
# DrugBank	DB00184	Nicotine
# DrugBank	DB00331	Metformin
# DrugBank	DB00368	Norepinephrine
# DrugBank	DB00396	Progesterone
# DrugBank	DB00457	Prazosin
# DrugBank	DB00458	Imipramine
# DrugBank	DB00501	Cimetidine
# DrugBank	DB00526	Oxaliplatin
# DrugBank	DB00536	Guanidine
# DrugBank	DB00541	Vincristine
# DrugBank	DB00575	Clonidine
# DrugBank	DB00624	Testosterone
# DrugBank	DB00667	Histamine Phosphate
# DrugBank	DB00709	Lamivudine
# DrugBank	DB00718	Adefovir Dipivoxil
# DrugBank	DB00762	Irinotecan
# DrugBank	DB00783	Estradiol
# DrugBank	DB00925	Phenoxybenzamine
# DrugBank	DB00988	Dopamine
# DrugBank	DB01035	Procainamide
# DrugBank	DB01042	Melphalan
# DrugBank	DB01151	Desipramine
# DrugBank	DB01394	Colchicine
# DrugBank	DB01577	Methamphetamine
# Ensembl	ENST00000275300	ENSP00000275300; ENSG00000146477
# FUNCTION	S22A3_HUMAN	Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain. {ECO 0000269|PubMed 10196521, ECO 0000269|PubMed 10966924}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_function	GO:0005329	dopamine transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015101	organic cation transmembrane transporter activity; IDA:MGI.
# GO_function	GO:0015651	quaternary ammonium group transmembrane transporter activity; IDA:MGI.
# GO_function	GO:0019534	toxin transporter activity; IEA:Ensembl.
# GO_process	GO:0006855	drug transmembrane transport; TAS:Reactome.
# GO_process	GO:0015695	organic cation transport; IDA:MGI.
# GO_process	GO:0015697	quaternary ammonium group transport; IDA:MGI.
# GO_process	GO:0015872	dopamine transport; IBA:GO_Central.
# GO_process	GO:0032098	regulation of appetite; IEA:Ensembl.
# GO_process	GO:0051615	histamine uptake; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	O75751	HS
# HGNC	HGNC:10967	SLC22A3
# INTERACTION	S22A3_HUMAN	P00519 ABL1; NbExp=2; IntAct=EBI-1752674, EBI-375543; 
# IntAct	O75751	2
# InterPro	IPR004749	Orgcat_transp/SVOP
# InterPro	IPR005829	Sugar_transporter_CS
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	604842	gene
# Organism	S22A3_HUMAN	Homo sapiens (Human)
# PROSITE	PS00216	SUGAR_TRANSPORT_1
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-2161517	Abacavir transmembrane transport
# Reactome	R-HSA-549127	Organic cation transport
# RecName	S22A3_HUMAN	Solute carrier family 22 member 3
# RefSeq	NP_068812	NM_021977.3
# SIMILARITY	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S22A3_HUMAN	Membrane; Multi-pass membrane protein. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.1.19.24	the major facilitator superfamily (mfs)
# TIGRFAMs	TIGR00898	2A0119
# TISSUE SPECIFICITY	S22A3_HUMAN	Expressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland, adrenal gland, kidney and brain cortex. No expression detected in spleen. {ECO 0000269|PubMed 10196521, ECO 0000269|PubMed 10966924, ECO 0000269|PubMed 9933568}. 
# UCSC	uc003qti	human
# eggNOG	ENOG410IRIE	Eukaryota
# eggNOG	ENOG410XSRI	LUCA
BLAST	swissprot:S22A3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S22A3_HUMAN
BioCyc	ZFISH:ENSG00000146477-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000146477-MONOMER
COXPRESdb	6581	http://coxpresdb.jp/data/gene/6581.shtml
CleanEx	HS_SLC22A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC22A3
DOI	10.1006/geno.1998.5639	http://dx.doi.org/10.1006/geno.1998.5639
DOI	10.1038/1557	http://dx.doi.org/10.1038/1557
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DrugBank	DB00122	http://www.drugbank.ca/drugs/DB00122
DrugBank	DB00182	http://www.drugbank.ca/drugs/DB00182
DrugBank	DB00184	http://www.drugbank.ca/drugs/DB00184
DrugBank	DB00331	http://www.drugbank.ca/drugs/DB00331
DrugBank	DB00368	http://www.drugbank.ca/drugs/DB00368
DrugBank	DB00396	http://www.drugbank.ca/drugs/DB00396
DrugBank	DB00457	http://www.drugbank.ca/drugs/DB00457
DrugBank	DB00458	http://www.drugbank.ca/drugs/DB00458
DrugBank	DB00501	http://www.drugbank.ca/drugs/DB00501
DrugBank	DB00526	http://www.drugbank.ca/drugs/DB00526
DrugBank	DB00536	http://www.drugbank.ca/drugs/DB00536
DrugBank	DB00541	http://www.drugbank.ca/drugs/DB00541
DrugBank	DB00575	http://www.drugbank.ca/drugs/DB00575
DrugBank	DB00624	http://www.drugbank.ca/drugs/DB00624
DrugBank	DB00667	http://www.drugbank.ca/drugs/DB00667
DrugBank	DB00709	http://www.drugbank.ca/drugs/DB00709
DrugBank	DB00718	http://www.drugbank.ca/drugs/DB00718
DrugBank	DB00762	http://www.drugbank.ca/drugs/DB00762
DrugBank	DB00783	http://www.drugbank.ca/drugs/DB00783
DrugBank	DB00925	http://www.drugbank.ca/drugs/DB00925
DrugBank	DB00988	http://www.drugbank.ca/drugs/DB00988
DrugBank	DB01035	http://www.drugbank.ca/drugs/DB01035
DrugBank	DB01042	http://www.drugbank.ca/drugs/DB01042
DrugBank	DB01151	http://www.drugbank.ca/drugs/DB01151
DrugBank	DB01394	http://www.drugbank.ca/drugs/DB01394
DrugBank	DB01577	http://www.drugbank.ca/drugs/DB01577
EMBL	AF078749	http://www.ebi.ac.uk/ena/data/view/AF078749
EMBL	AJ001417	http://www.ebi.ac.uk/ena/data/view/AJ001417
EMBL	AK314590	http://www.ebi.ac.uk/ena/data/view/AK314590
EMBL	AL355506	http://www.ebi.ac.uk/ena/data/view/AL355506
EMBL	AL355506	http://www.ebi.ac.uk/ena/data/view/AL355506
EMBL	AL591069	http://www.ebi.ac.uk/ena/data/view/AL591069
EMBL	AL591069	http://www.ebi.ac.uk/ena/data/view/AL591069
EMBL	CH471051	http://www.ebi.ac.uk/ena/data/view/CH471051
Ensembl	ENST00000275300	http://www.ensembl.org/id/ENST00000275300
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0005329	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005329
GO_function	GO:0015101	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015101
GO_function	GO:0015651	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015651
GO_function	GO:0019534	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019534
GO_process	GO:0006855	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006855
GO_process	GO:0015695	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015695
GO_process	GO:0015697	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015697
GO_process	GO:0015872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015872
GO_process	GO:0032098	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032098
GO_process	GO:0051615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051615
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC22A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC22A3
GeneID	6581	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6581
GeneTree	ENSGT00760000118852	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118852
HGNC	HGNC:10967	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10967
HOGENOM	HOG000234568	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234568&db=HOGENOM6
HOVERGEN	HBG061545	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG061545&db=HOVERGEN
HPA	HPA029750	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA029750
InParanoid	O75751	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O75751
IntAct	O75751	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O75751*
InterPro	IPR004749	http://www.ebi.ac.uk/interpro/entry/IPR004749
InterPro	IPR005829	http://www.ebi.ac.uk/interpro/entry/IPR005829
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	6581	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6581
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6581	http://www.genome.jp/dbget-bin/www_bget?hsa:6581
KEGG_Orthology	KO:K08200	http://www.genome.jp/dbget-bin/www_bget?KO:K08200
MIM	604842	http://www.ncbi.nlm.nih.gov/omim/604842
OMA	CQRYLLE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CQRYLLE
OrthoDB	EOG091G05AC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05AC
PROSITE	PS00216	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00216
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:S22A3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S22A3_HUMAN
PSORT-B	swissprot:S22A3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S22A3_HUMAN
PSORT2	swissprot:S22A3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S22A3_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA330	http://www.pharmgkb.org/do/serve?objId=PA330&objCls=Gene
Phobius	swissprot:S22A3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S22A3_HUMAN
PhylomeDB	O75751	http://phylomedb.org/?seqid=O75751
ProteinModelPortal	O75751	http://www.proteinmodelportal.org/query/uniprot/O75751
PubMed	10196521	http://www.ncbi.nlm.nih.gov/pubmed/10196521
PubMed	10966924	http://www.ncbi.nlm.nih.gov/pubmed/10966924
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	9933568	http://www.ncbi.nlm.nih.gov/pubmed/9933568
Reactome	R-HSA-2161517	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2161517
Reactome	R-HSA-549127	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-549127
RefSeq	NP_068812	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_068812
STRING	9606.ENSP00000275300	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000275300&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.19.24	http://www.tcdb.org/search/result.php?tc=2.A.1.19.24
TIGRFAMs	TIGR00898	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00898
UCSC	uc003qti	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003qti&org=rat
UniGene	Hs.567337	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.567337
UniProtKB	S22A3_HUMAN	http://www.uniprot.org/uniprot/S22A3_HUMAN
UniProtKB-AC	O75751	http://www.uniprot.org/uniprot/O75751
charge	swissprot:S22A3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S22A3_HUMAN
eggNOG	ENOG410IRIE	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IRIE
eggNOG	ENOG410XSRI	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSRI
epestfind	swissprot:S22A3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S22A3_HUMAN
garnier	swissprot:S22A3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S22A3_HUMAN
helixturnhelix	swissprot:S22A3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S22A3_HUMAN
hmoment	swissprot:S22A3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S22A3_HUMAN
iep	swissprot:S22A3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S22A3_HUMAN
inforesidue	swissprot:S22A3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S22A3_HUMAN
neXtProt	NX_O75751	http://www.nextprot.org/db/entry/NX_O75751
octanol	swissprot:S22A3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S22A3_HUMAN
pepcoil	swissprot:S22A3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S22A3_HUMAN
pepdigest	swissprot:S22A3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S22A3_HUMAN
pepinfo	swissprot:S22A3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S22A3_HUMAN
pepnet	swissprot:S22A3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S22A3_HUMAN
pepstats	swissprot:S22A3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S22A3_HUMAN
pepwheel	swissprot:S22A3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S22A3_HUMAN
pepwindow	swissprot:S22A3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S22A3_HUMAN
sigcleave	swissprot:S22A3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S22A3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ABCA6_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8N139-1; Sequence=Displayed; Name=2; Synonyms=ABCA6delta-139; IsoId=Q8N139-2; Sequence=VSP_020697, VSP_020698; Name=3; IsoId=Q8N139-3; Sequence=VSP_020695, VSP_020696; Note=No experimental confirmation available.; 
# CCDS	CCDS11683	-. [Q8N139-1]
# ChiTaRS	ABCA6	human
# DEVELOPMENTAL STAGE	Expressed in fetal kidney, lung and liver. {ECO	0000269|Ref.2}. 
# Ensembl	ENST00000284425	ENSP00000284425; ENSG00000154262. [Q8N139-1]
# Ensembl	ENST00000590645	ENSP00000466862; ENSG00000154262. [Q8N139-3]
# FUNCTION	ABCA6_HUMAN	Probable transporter which may play a role in macrophage lipid homeostasis. 
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IBA:GO_Central.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; IBA:GO_Central.
# GO_process	GO:0006869	lipid transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# Gene3D	3.40.50.300	-; 2.
# Genevisible	Q8N139	HS
# HGNC	HGNC:36	ABCA6
# INDUCTION	Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages. {ECO:0000269|PubMed	10639163}. 
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR026082	ABC_A
# InterPro	IPR027417	P-loop_NTPase
# InterPro	IPR030368	ABCA6
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko02010	ABC transporters
# MIM	612504	gene
# Organism	ABCA6_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR19229	PTHR19229
# PANTHER	PTHR19229:SF13	PTHR19229:SF13
# PROSITE	PS50893	ABC_TRANSPORTER_2; 2
# Pfam	PF00005	ABC_tran; 2
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-1369062	ABC transporters in lipid homeostasis
# RecName	ABCA6_HUMAN	ATP-binding cassette sub-family A member 6
# RefSeq	NP_525023	NM_080284.2. [Q8N139-1]
# RefSeq	XP_016879893	XM_017024404.1. [Q8N139-1]
# RefSeq	XP_016879894	XM_017024405.1. [Q8N139-1]
# SEQUENCE CAUTION	Sequence=AAM77557.1; Type=Frameshift; Positions=998, 1000; Evidence={ECO:0000305}; Sequence=AAM77558.1; Type=Frameshift; Positions=998, 1000; Evidence={ECO	0000305}; Sequence=BAC04994.1; Type=Erroneous initiation; Evidence={ECO:0000305}; 
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCA family. {ECO	0000305}. 
# SIMILARITY	Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA; 2
# SUBCELLULAR LOCATION	ABCA6_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF52540	SSF52540; 2
# TCDB	3.A.1.211.15	the atp-binding cassette (abc) superfamily
# TISSUE SPECIFICITY	Widely expressed with higher expression in liver. {ECO:0000269|PubMed	11478798, ECO:0000269|Ref.2}. 
# TopDownProteomics	Q8N139-3	-. [Q8N139-3]
# UCSC	uc002jhw	human. [Q8N139-1]
# WEB RESOURCE	ABCA6_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=Q8N139";
# eggNOG	COG1131	LUCA
# eggNOG	KOG0059	Eukaryota
BLAST	swissprot:ABCA6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCA6_HUMAN
COXPRESdb	23460	http://coxpresdb.jp/data/gene/23460.shtml
CleanEx	HS_ABCA6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCA6
DOI	10.1006/bbrc.2001.5326	http://dx.doi.org/10.1006/bbrc.2001.5326
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.97.2.817	http://dx.doi.org/10.1073/pnas.97.2.817
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF373290	http://www.ebi.ac.uk/ena/data/view/AF373290
EMBL	AF373291	http://www.ebi.ac.uk/ena/data/view/AF373291
EMBL	AF373292	http://www.ebi.ac.uk/ena/data/view/AF373292
EMBL	AF373293	http://www.ebi.ac.uk/ena/data/view/AF373293
EMBL	AF373294	http://www.ebi.ac.uk/ena/data/view/AF373294
EMBL	AF373295	http://www.ebi.ac.uk/ena/data/view/AF373295
EMBL	AF373296	http://www.ebi.ac.uk/ena/data/view/AF373296
EMBL	AF373297	http://www.ebi.ac.uk/ena/data/view/AF373297
EMBL	AF373298	http://www.ebi.ac.uk/ena/data/view/AF373298
EMBL	AF373299	http://www.ebi.ac.uk/ena/data/view/AF373299
EMBL	AF373300	http://www.ebi.ac.uk/ena/data/view/AF373300
EMBL	AF373301	http://www.ebi.ac.uk/ena/data/view/AF373301
EMBL	AF373302	http://www.ebi.ac.uk/ena/data/view/AF373302
EMBL	AF373303	http://www.ebi.ac.uk/ena/data/view/AF373303
EMBL	AF373304	http://www.ebi.ac.uk/ena/data/view/AF373304
EMBL	AF373305	http://www.ebi.ac.uk/ena/data/view/AF373305
EMBL	AF373306	http://www.ebi.ac.uk/ena/data/view/AF373306
EMBL	AF373307	http://www.ebi.ac.uk/ena/data/view/AF373307
EMBL	AF373308	http://www.ebi.ac.uk/ena/data/view/AF373308
EMBL	AF373309	http://www.ebi.ac.uk/ena/data/view/AF373309
EMBL	AF373310	http://www.ebi.ac.uk/ena/data/view/AF373310
EMBL	AF373311	http://www.ebi.ac.uk/ena/data/view/AF373311
EMBL	AF373312	http://www.ebi.ac.uk/ena/data/view/AF373312
EMBL	AF373313	http://www.ebi.ac.uk/ena/data/view/AF373313
EMBL	AF373314	http://www.ebi.ac.uk/ena/data/view/AF373314
EMBL	AF373315	http://www.ebi.ac.uk/ena/data/view/AF373315
EMBL	AF373316	http://www.ebi.ac.uk/ena/data/view/AF373316
EMBL	AF373317	http://www.ebi.ac.uk/ena/data/view/AF373317
EMBL	AF373318	http://www.ebi.ac.uk/ena/data/view/AF373318
EMBL	AF373319	http://www.ebi.ac.uk/ena/data/view/AF373319
EMBL	AF373320	http://www.ebi.ac.uk/ena/data/view/AF373320
EMBL	AF373321	http://www.ebi.ac.uk/ena/data/view/AF373321
EMBL	AF373322	http://www.ebi.ac.uk/ena/data/view/AF373322
EMBL	AF373323	http://www.ebi.ac.uk/ena/data/view/AF373323
EMBL	AF373324	http://www.ebi.ac.uk/ena/data/view/AF373324
EMBL	AF373325	http://www.ebi.ac.uk/ena/data/view/AF373325
EMBL	AF373326	http://www.ebi.ac.uk/ena/data/view/AF373326
EMBL	AF373327	http://www.ebi.ac.uk/ena/data/view/AF373327
EMBL	AF373328	http://www.ebi.ac.uk/ena/data/view/AF373328
EMBL	AK097296	http://www.ebi.ac.uk/ena/data/view/AK097296
EMBL	AY028898	http://www.ebi.ac.uk/ena/data/view/AY028898
EMBL	BC070125	http://www.ebi.ac.uk/ena/data/view/BC070125
Ensembl	ENST00000284425	http://www.ensembl.org/id/ENST00000284425
Ensembl	ENST00000590645	http://www.ensembl.org/id/ENST00000590645
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GO_process	GO:0006869	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006869
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCA6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCA6
GeneID	23460	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23460
GeneTree	ENSGT00760000118965	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118965
H-InvDB	HIX0014121	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0014121
HGNC	HGNC:36	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:36
HOGENOM	HOG000231057	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231057&db=HOGENOM6
HOVERGEN	HBG079884	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG079884&db=HOVERGEN
InParanoid	Q8N139	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8N139
IntAct	Q8N139	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8N139*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR026082	http://www.ebi.ac.uk/interpro/entry/IPR026082
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
InterPro	IPR030368	http://www.ebi.ac.uk/interpro/entry/IPR030368
Jabion	23460	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=23460
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:23460	http://www.genome.jp/dbget-bin/www_bget?hsa:23460
KEGG_Orthology	KO:K05649	http://www.genome.jp/dbget-bin/www_bget?KO:K05649
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
MIM	612504	http://www.ncbi.nlm.nih.gov/omim/612504
OMA	CFQHQRT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CFQHQRT
OrthoDB	EOG091G00AG	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00AG
PANTHER	PTHR19229	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19229
PANTHER	PTHR19229:SF13	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19229:SF13
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PSORT	swissprot:ABCA6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCA6_HUMAN
PSORT-B	swissprot:ABCA6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCA6_HUMAN
PSORT2	swissprot:ABCA6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCA6_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
PharmGKB	PA24381	http://www.pharmgkb.org/do/serve?objId=PA24381&objCls=Gene
Phobius	swissprot:ABCA6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCA6_HUMAN
PhylomeDB	Q8N139	http://phylomedb.org/?seqid=Q8N139
ProteinModelPortal	Q8N139	http://www.proteinmodelportal.org/query/uniprot/Q8N139
PubMed	10639163	http://www.ncbi.nlm.nih.gov/pubmed/10639163
PubMed	11478798	http://www.ncbi.nlm.nih.gov/pubmed/11478798
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
Reactome	R-HSA-1369062	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1369062
RefSeq	NP_525023	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_525023
RefSeq	XP_016879893	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016879893
RefSeq	XP_016879894	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016879894
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	Q8N139	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8N139
STRING	9606.ENSP00000284425	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000284425&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TCDB	3.A.1.211.15	http://www.tcdb.org/search/result.php?tc=3.A.1.211.15
UCSC	uc002jhw	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002jhw&org=rat
UniGene	Hs.709514	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.709514
UniProtKB	ABCA6_HUMAN	http://www.uniprot.org/uniprot/ABCA6_HUMAN
UniProtKB-AC	Q8N139	http://www.uniprot.org/uniprot/Q8N139
charge	swissprot:ABCA6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCA6_HUMAN
eggNOG	COG1131	http://eggnogapi.embl.de/nog_data/html/tree/COG1131
eggNOG	KOG0059	http://eggnogapi.embl.de/nog_data/html/tree/KOG0059
epestfind	swissprot:ABCA6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCA6_HUMAN
garnier	swissprot:ABCA6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCA6_HUMAN
helixturnhelix	swissprot:ABCA6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCA6_HUMAN
hmoment	swissprot:ABCA6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCA6_HUMAN
iep	swissprot:ABCA6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCA6_HUMAN
inforesidue	swissprot:ABCA6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCA6_HUMAN
neXtProt	NX_Q8N139	http://www.nextprot.org/db/entry/NX_Q8N139
octanol	swissprot:ABCA6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCA6_HUMAN
pepcoil	swissprot:ABCA6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCA6_HUMAN
pepdigest	swissprot:ABCA6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCA6_HUMAN
pepinfo	swissprot:ABCA6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCA6_HUMAN
pepnet	swissprot:ABCA6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCA6_HUMAN
pepstats	swissprot:ABCA6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCA6_HUMAN
pepwheel	swissprot:ABCA6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCA6_HUMAN
pepwindow	swissprot:ABCA6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCA6_HUMAN
sigcleave	swissprot:ABCA6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCA6_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7LBE3-1; Sequence=Displayed; Name=2; IsoId=Q7LBE3-2; Sequence=VSP_054056; Note=Ref.2 (AAL26867) and Ref.4 (EAW91587) sequences are in conflict in position: 804	R->G. {ECO:0000305}; 
# AltName	S26A9_HUMAN	Anion transporter/exchanger protein 9
# CCDS	CCDS30989	-. [Q7LBE3-2]
# CCDS	CCDS30990	-. [Q7LBE3-1]
# Ensembl	ENST00000340781	ENSP00000341682; ENSG00000174502. [Q7LBE3-2]
# Ensembl	ENST00000367134	ENSP00000356102; ENSG00000174502. [Q7LBE3-2]
# Ensembl	ENST00000367135	ENSP00000356103; ENSG00000174502. [Q7LBE3-1]
# FUNCTION	S26A9_HUMAN	DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion. Inhibited by ammonium and thiosulfate. {ECO 0000269|PubMed 11834742, ECO 0000269|PubMed 15800055}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0009986	cell surface; IDA:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005254	chloride channel activity; IDA:UniProtKB.
# GO_function	GO:0008271	secondary active sulfate transmembrane transporter activity; IEA:InterPro.
# GO_function	GO:0015106	bicarbonate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015116	sulfate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0019531	oxalate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0051117	ATPase binding; IPI:UniProtKB.
# GO_function	S26A9_HUMAN	GO 0015301 anion anion antiporter activity; IDA UniProtKB.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006820	anion transport; IDA:UniProtKB.
# GO_process	GO:0006821	chloride transport; IDA:UniProtKB.
# GO_process	GO:0010628	positive regulation of gene expression; IDA:UniProtKB.
# GO_process	GO:0015701	bicarbonate transport; IDA:UniProtKB.
# GO_process	GO:0042391	regulation of membrane potential; IBA:GO_Central.
# GO_process	GO:0051453	regulation of intracellular pH; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# Gene3D	3.30.750.24	-; 2.
# Genevisible	Q7LBE3	HS
# HGNC	HGNC:14469	SLC26A9
# InterPro	IPR001902	SLC26A/SulP_fam
# InterPro	IPR002645	STAS_dom
# InterPro	IPR011547	SLC26A/SulP_dom
# InterPro	IPR030306	SLC26A9
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04978	Mineral absorption
# MIM	608481	gene
# Organism	S26A9_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11814	PTHR11814; 2
# PANTHER	PTHR11814:SF17	PTHR11814:SF17; 2
# PROSITE	PS50801	STAS
# Pfam	PF00916	Sulfate_transp
# Pfam	PF01740	STAS
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-427601	Multifunctional anion exchangers
# RecName	S26A9_HUMAN	Solute carrier family 26 member 9
# RefSeq	NP_443166	NM_052934.3. [Q7LBE3-1]
# RefSeq	NP_599152	NM_134325.2. [Q7LBE3-2]
# SIMILARITY	Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. {ECO	0000305}. 
# SIMILARITY	Contains 1 STAS domain. {ECO:0000255|PROSITE- ProRule	PRU00198}.
# SUBCELLULAR LOCATION	S26A9_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF52091	SSF52091; 2
# TCDB	2.A.53.2.15	the sulfate permease (sulp) family
# TIGRFAMs	TIGR00815	sulP
# TISSUE SPECIFICITY	Predominantly expressed in lung at the luminal side of the bronchiolar and alveolar epithelium of lung. To a lower extent, also expressed in pancreas and prostate. {ECO:0000269|PubMed	11834742}. 
# UCSC	uc001hdp	human. [Q7LBE3-1]
# eggNOG	COG0659	LUCA
# eggNOG	KOG0236	Eukaryota
BLAST	swissprot:S26A9_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S26A9_HUMAN
COXPRESdb	115019	http://coxpresdb.jp/data/gene/115019.shtml
CleanEx	HS_SLC26A9	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC26A9
DOI	10.1002/humu.22107	http://dx.doi.org/10.1002/humu.22107
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1074/jbc.M111802200	http://dx.doi.org/10.1074/jbc.M111802200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1152/ajpcell.00030.2005	http://dx.doi.org/10.1152/ajpcell.00030.2005
EMBL	AF314958	http://www.ebi.ac.uk/ena/data/view/AF314958
EMBL	AF331525	http://www.ebi.ac.uk/ena/data/view/AF331525
EMBL	AL713965	http://www.ebi.ac.uk/ena/data/view/AL713965
EMBL	BC136538	http://www.ebi.ac.uk/ena/data/view/BC136538
EMBL	BC151208	http://www.ebi.ac.uk/ena/data/view/BC151208
EMBL	CH471067	http://www.ebi.ac.uk/ena/data/view/CH471067
EMBL	CH471067	http://www.ebi.ac.uk/ena/data/view/CH471067
Ensembl	ENST00000340781	http://www.ensembl.org/id/ENST00000340781
Ensembl	ENST00000367134	http://www.ensembl.org/id/ENST00000367134
Ensembl	ENST00000367135	http://www.ensembl.org/id/ENST00000367135
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0008271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008271
GO_function	GO:0015106	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015106
GO_function	GO:0015116	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015116
GO_function	GO:0015301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015301
GO_function	GO:0019531	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019531
GO_function	GO:0051117	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051117
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006820	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006820
GO_process	GO:0006821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006821
GO_process	GO:0010628	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010628
GO_process	GO:0015701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015701
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
Gene3D	3.30.750.24	http://www.cathdb.info/version/latest/superfamily/3.30.750.24
GeneCards	SLC26A9	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC26A9
GeneID	115019	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=115019
GeneTree	ENSGT00760000119026	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119026
HGNC	HGNC:14469	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14469
HOGENOM	HOG000006546	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006546&db=HOGENOM6
HOVERGEN	HBG000639	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000639&db=HOVERGEN
HPA	HPA051485	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA051485
InParanoid	Q7LBE3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q7LBE3
InterPro	IPR001902	http://www.ebi.ac.uk/interpro/entry/IPR001902
InterPro	IPR002645	http://www.ebi.ac.uk/interpro/entry/IPR002645
InterPro	IPR011547	http://www.ebi.ac.uk/interpro/entry/IPR011547
InterPro	IPR030306	http://www.ebi.ac.uk/interpro/entry/IPR030306
Jabion	115019	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=115019
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:115019	http://www.genome.jp/dbget-bin/www_bget?hsa:115019
KEGG_Orthology	KO:K14706	http://www.genome.jp/dbget-bin/www_bget?KO:K14706
KEGG_Pathway	ko04978	http://www.genome.jp/kegg-bin/show_pathway?ko04978
MIM	608481	http://www.ncbi.nlm.nih.gov/omim/608481
OMA	FMQFGFV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FMQFGFV
OrthoDB	EOG091G07RT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07RT
PANTHER	PTHR11814	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11814
PANTHER	PTHR11814:SF17	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11814:SF17
PROSITE	PS50801	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50801
PSORT	swissprot:S26A9_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S26A9_HUMAN
PSORT-B	swissprot:S26A9_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S26A9_HUMAN
PSORT2	swissprot:S26A9_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S26A9_HUMAN
Pfam	PF00916	http://pfam.xfam.org/family/PF00916
Pfam	PF01740	http://pfam.xfam.org/family/PF01740
PharmGKB	PA37886	http://www.pharmgkb.org/do/serve?objId=PA37886&objCls=Gene
Phobius	swissprot:S26A9_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S26A9_HUMAN
PhylomeDB	Q7LBE3	http://phylomedb.org/?seqid=Q7LBE3
ProteinModelPortal	Q7LBE3	http://www.proteinmodelportal.org/query/uniprot/Q7LBE3
PubMed	11834742	http://www.ncbi.nlm.nih.gov/pubmed/11834742
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15800055	http://www.ncbi.nlm.nih.gov/pubmed/15800055
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	22544634	http://www.ncbi.nlm.nih.gov/pubmed/22544634
Reactome	R-HSA-427601	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-427601
RefSeq	NP_443166	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_443166
RefSeq	NP_599152	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_599152
SMR	Q7LBE3	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q7LBE3
STRING	9606.ENSP00000341682	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000341682&targetmode=cogs
SUPFAM	SSF52091	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52091
TCDB	2.A.53.2.15	http://www.tcdb.org/search/result.php?tc=2.A.53.2.15
TIGRFAMs	TIGR00815	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00815
UCSC	uc001hdp	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001hdp&org=rat
UniGene	Hs.164073	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.164073
UniProtKB	S26A9_HUMAN	http://www.uniprot.org/uniprot/S26A9_HUMAN
UniProtKB-AC	Q7LBE3	http://www.uniprot.org/uniprot/Q7LBE3
charge	swissprot:S26A9_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S26A9_HUMAN
eggNOG	COG0659	http://eggnogapi.embl.de/nog_data/html/tree/COG0659
eggNOG	KOG0236	http://eggnogapi.embl.de/nog_data/html/tree/KOG0236
epestfind	swissprot:S26A9_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S26A9_HUMAN
garnier	swissprot:S26A9_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S26A9_HUMAN
helixturnhelix	swissprot:S26A9_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S26A9_HUMAN
hmoment	swissprot:S26A9_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S26A9_HUMAN
iep	swissprot:S26A9_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S26A9_HUMAN
inforesidue	swissprot:S26A9_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S26A9_HUMAN
neXtProt	NX_Q7LBE3	http://www.nextprot.org/db/entry/NX_Q7LBE3
octanol	swissprot:S26A9_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S26A9_HUMAN
pepcoil	swissprot:S26A9_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S26A9_HUMAN
pepdigest	swissprot:S26A9_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S26A9_HUMAN
pepinfo	swissprot:S26A9_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S26A9_HUMAN
pepnet	swissprot:S26A9_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S26A9_HUMAN
pepstats	swissprot:S26A9_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S26A9_HUMAN
pepwheel	swissprot:S26A9_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S26A9_HUMAN
pepwindow	swissprot:S26A9_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S26A9_HUMAN
sigcleave	swissprot:S26A9_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S26A9_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=7; Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=Q9UP95-1; Sequence=Displayed; Name=2; IsoId=Q9UP95-2; Sequence=VSP_006113, VSP_006114; Name=3; IsoId=Q9UP95-3; Sequence=VSP_006112; Name=4; IsoId=Q9UP95-4; Sequence=VSP_006108, VSP_006109, VSP_006110, VSP_006111; Name=5; IsoId=Q9UP95-5; Sequence=VSP_044596; Note=No experimental confirmation available.; Name=6; IsoId=Q9UP95-6; Sequence=VSP_046146; Note=No experimental confirmation available. Ref.3 (BAH14786) sequence is in conflict in position: 4	E->G. {ECO:0000305}; Name=7; IsoId=Q9UP95-7; Sequence=VSP_046369; Note=No experimental confirmation available.; 
# AltName	S12A4_HUMAN	Electroneutral potassium-chloride cotransporter 1
# AltName	S12A4_HUMAN	Erythroid K-Cl cotransporter 1
# BioGrid	112449	25
# CCDS	CCDS10855	-. [Q9UP95-1]
# CCDS	CCDS54030	-. [Q9UP95-6]
# CCDS	CCDS54031	-. [Q9UP95-5]
# CCDS	CCDS54032	-. [Q9UP95-7]
# DrugBank	DB00761	Potassium Chloride
# DrugBank	DB00887	Bumetanide
# ENZYME REGULATION	Inhibited by WNK3. {ECO:0000269|PubMed	21613606}. 
# Ensembl	ENST00000316341	ENSP00000318557; ENSG00000124067. [Q9UP95-1]
# Ensembl	ENST00000422611	ENSP00000395983; ENSG00000124067. [Q9UP95-7]
# Ensembl	ENST00000537830	ENSP00000445962; ENSG00000124067. [Q9UP95-6]
# Ensembl	ENST00000541864	ENSP00000438334; ENSG00000124067. [Q9UP95-5]
# Ensembl	ENST00000576616	ENSP00000458902; ENSG00000124067. [Q9UP95-2]
# ExpressionAtlas	Q9UP95	baseline and differential
# FUNCTION	S12A4_HUMAN	Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity. {ECO 0000250}. 
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_function	GO:0019901	protein kinase binding; IPI:ParkinsonsUK-UCL.
# GO_function	GO:0022820	potassium ion symporter activity; IBA:GO_Central.
# GO_function	S12A4_HUMAN	GO 0015379 potassium chloride symporter activity; TAS Reactome.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006884	cell volume homeostasis; TAS:ProtInc.
# GO_process	GO:0007268	chemical synaptic transmission; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0042592	homeostatic process
# Genevisible	Q9UP95	HS
# HGNC	HGNC:10913	SLC12A4
# IntAct	Q9UP95	9
# InterPro	IPR000076	KCL_cotranspt
# InterPro	IPR000622	KCC1
# InterPro	IPR004841	AA-permease/SLC12A_dom
# InterPro	IPR004842	SLC12A_fam
# InterPro	IPR018491	SLC12_C
# KEGG_Brite	ko02001	Solute carrier family
# MIM	604119	gene
# Organism	S12A4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11827:SF46	PTHR11827:SF46; 4
# PRINTS	PR01081	KCLTRNSPORT
# PRINTS	PR01082	KCLTRNSPORT1
# PTM	S12A4_HUMAN	N-glycosylated. 
# Pfam	PF00324	AA_permease; 2
# Pfam	PF03522	SLC12; 2
# Proteomes	UP000005640	Chromosome 16
# Reactome	R-HSA-426117	Cation-coupled Chloride cotransporters
# RecName	S12A4_HUMAN	Solute carrier family 12 member 4
# RefSeq	NP_001139433	NM_001145961.1
# RefSeq	NP_001139434	NM_001145962.1. [Q9UP95-7]
# RefSeq	NP_001139435	NM_001145963.1. [Q9UP95-6]
# RefSeq	NP_001139436	NM_001145964.1. [Q9UP95-5]
# RefSeq	NP_005063	NM_005072.4. [Q9UP95-1]
# SEQUENCE CAUTION	Sequence=AAC35282.1; Type=Frameshift; Positions=454; Evidence={ECO:0000305}; Sequence=BAG57330.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the SLC12A transporter family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S12A4_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Homomultimer and heteromultimer with other K-Cl cotransporters. {ECO:0000269|PubMed	11551954}. 
# TCDB	2.A.30.5	the cation-chloride cotransporter (ccc) family
# TIGRFAMs	TIGR00930	2a30
# TISSUE SPECIFICITY	S12A4_HUMAN	Ubiquitous. Levels are much higher in erythrocytes from patients with Hb SC and Hb SS compared to normal AA erythrocytes. This may contribute to red blood cell dehydration and to the manifestation of sickle cell disease by increasing the intracellular concentration of HbS. Isoform 1 was not detected in circulating reticulocytes. 
# UCSC	uc002euz	human. [Q9UP95-1]
# eggNOG	COG0531	LUCA
# eggNOG	KOG2082	Eukaryota
BLAST	swissprot:S12A4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S12A4_HUMAN
BioCyc	ZFISH:ENSG00000124067-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000124067-MONOMER
COXPRESdb	6560	http://coxpresdb.jp/data/gene/6560.shtml
CleanEx	HS_SLC12A4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC12A4
DOI	10.1006/bcmd.1998.0168	http://dx.doi.org/10.1006/bcmd.1998.0168
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature03187	http://dx.doi.org/10.1038/nature03187
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/jbc.271.27.16237	http://dx.doi.org/10.1074/jbc.271.27.16237
DOI	10.1074/jbc.M107155200	http://dx.doi.org/10.1074/jbc.M107155200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1152/ajpcell.00070.2011	http://dx.doi.org/10.1152/ajpcell.00070.2011
DrugBank	DB00761	http://www.drugbank.ca/drugs/DB00761
DrugBank	DB00887	http://www.drugbank.ca/drugs/DB00887
EMBL	AC040162	http://www.ebi.ac.uk/ena/data/view/AC040162
EMBL	AF047338	http://www.ebi.ac.uk/ena/data/view/AF047338
EMBL	AF053402	http://www.ebi.ac.uk/ena/data/view/AF053402
EMBL	AF054505	http://www.ebi.ac.uk/ena/data/view/AF054505
EMBL	AF054506	http://www.ebi.ac.uk/ena/data/view/AF054506
EMBL	AK293956	http://www.ebi.ac.uk/ena/data/view/AK293956
EMBL	AK299042	http://www.ebi.ac.uk/ena/data/view/AK299042
EMBL	AK302790	http://www.ebi.ac.uk/ena/data/view/AK302790
EMBL	AK316415	http://www.ebi.ac.uk/ena/data/view/AK316415
EMBL	AY026038	http://www.ebi.ac.uk/ena/data/view/AY026038
EMBL	BC021193	http://www.ebi.ac.uk/ena/data/view/BC021193
EMBL	U55054	http://www.ebi.ac.uk/ena/data/view/U55054
Ensembl	ENST00000316341	http://www.ensembl.org/id/ENST00000316341
Ensembl	ENST00000422611	http://www.ensembl.org/id/ENST00000422611
Ensembl	ENST00000537830	http://www.ensembl.org/id/ENST00000537830
Ensembl	ENST00000541864	http://www.ensembl.org/id/ENST00000541864
Ensembl	ENST00000576616	http://www.ensembl.org/id/ENST00000576616
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0015379	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015379
GO_function	GO:0019901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019901
GO_function	GO:0022820	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022820
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006884	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006884
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GeneCards	SLC12A4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC12A4
GeneID	6560	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6560
GeneTree	ENSGT00760000119053	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119053
HGNC	HGNC:10913	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10913
HOGENOM	HOG000092644	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000092644&db=HOGENOM6
HOVERGEN	HBG052852	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052852&db=HOVERGEN
HPA	HPA041138	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA041138
InParanoid	Q9UP95	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UP95
IntAct	Q9UP95	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9UP95*
InterPro	IPR000076	http://www.ebi.ac.uk/interpro/entry/IPR000076
InterPro	IPR000622	http://www.ebi.ac.uk/interpro/entry/IPR000622
InterPro	IPR004841	http://www.ebi.ac.uk/interpro/entry/IPR004841
InterPro	IPR004842	http://www.ebi.ac.uk/interpro/entry/IPR004842
InterPro	IPR018491	http://www.ebi.ac.uk/interpro/entry/IPR018491
Jabion	6560	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6560
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6560	http://www.genome.jp/dbget-bin/www_bget?hsa:6560
KEGG_Orthology	KO:K14427	http://www.genome.jp/dbget-bin/www_bget?KO:K14427
MIM	604119	http://www.ncbi.nlm.nih.gov/omim/604119
MINT	MINT-1191426	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1191426
OMA	VATQLWK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VATQLWK
OrthoDB	EOG091G0WB4	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0WB4
PANTHER	PTHR11827:SF46	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11827:SF46
PRINTS	PR01081	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01081
PRINTS	PR01082	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01082
PSORT	swissprot:S12A4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S12A4_HUMAN
PSORT-B	swissprot:S12A4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S12A4_HUMAN
PSORT2	swissprot:S12A4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S12A4_HUMAN
Pfam	PF00324	http://pfam.xfam.org/family/PF00324
Pfam	PF03522	http://pfam.xfam.org/family/PF03522
PharmGKB	PA35807	http://www.pharmgkb.org/do/serve?objId=PA35807&objCls=Gene
Phobius	swissprot:S12A4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S12A4_HUMAN
PhylomeDB	Q9UP95	http://phylomedb.org/?seqid=Q9UP95
ProteinModelPortal	Q9UP95	http://www.proteinmodelportal.org/query/uniprot/Q9UP95
PubMed	10564083	http://www.ncbi.nlm.nih.gov/pubmed/10564083
PubMed	11551954	http://www.ncbi.nlm.nih.gov/pubmed/11551954
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15616553	http://www.ncbi.nlm.nih.gov/pubmed/15616553
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	21613606	http://www.ncbi.nlm.nih.gov/pubmed/21613606
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	8663127	http://www.ncbi.nlm.nih.gov/pubmed/8663127
PubMed	9516379	http://www.ncbi.nlm.nih.gov/pubmed/9516379
Reactome	R-HSA-426117	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-426117
RefSeq	NP_001139433	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001139433
RefSeq	NP_001139434	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001139434
RefSeq	NP_001139435	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001139435
RefSeq	NP_001139436	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001139436
RefSeq	NP_005063	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005063
STRING	9606.ENSP00000395983	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000395983&targetmode=cogs
TCDB	2.A.30.5	http://www.tcdb.org/search/result.php?tc=2.A.30.5
TIGRFAMs	TIGR00930	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00930
UCSC	uc002euz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002euz&org=rat
UniGene	Hs.10094	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.10094
UniProtKB	S12A4_HUMAN	http://www.uniprot.org/uniprot/S12A4_HUMAN
UniProtKB-AC	Q9UP95	http://www.uniprot.org/uniprot/Q9UP95
charge	swissprot:S12A4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S12A4_HUMAN
eggNOG	COG0531	http://eggnogapi.embl.de/nog_data/html/tree/COG0531
eggNOG	KOG2082	http://eggnogapi.embl.de/nog_data/html/tree/KOG2082
epestfind	swissprot:S12A4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S12A4_HUMAN
garnier	swissprot:S12A4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S12A4_HUMAN
helixturnhelix	swissprot:S12A4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S12A4_HUMAN
hmoment	swissprot:S12A4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S12A4_HUMAN
iep	swissprot:S12A4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S12A4_HUMAN
inforesidue	swissprot:S12A4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S12A4_HUMAN
neXtProt	NX_Q9UP95	http://www.nextprot.org/db/entry/NX_Q9UP95
octanol	swissprot:S12A4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S12A4_HUMAN
pepcoil	swissprot:S12A4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S12A4_HUMAN
pepdigest	swissprot:S12A4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S12A4_HUMAN
pepinfo	swissprot:S12A4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S12A4_HUMAN
pepnet	swissprot:S12A4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S12A4_HUMAN
pepstats	swissprot:S12A4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S12A4_HUMAN
pepwheel	swissprot:S12A4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S12A4_HUMAN
pepwindow	swissprot:S12A4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S12A4_HUMAN
sigcleave	swissprot:S12A4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S12A4_HUMAN
## Database	ID	URL or Descriptions
# AltName	ASIC5_HUMAN	Amiloride-sensitive cation channel 5
# AltName	ASIC5_HUMAN	Human intestine Na(+) channel
# Ensembl	ENST00000537611	ENSP00000442477; ENSG00000256394
# FUNCTION	ASIC5_HUMAN	Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride. {ECO 0000269|PubMed 10767424}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015252	hydrogen ion channel activity; IEA:Ensembl.
# GO_function	GO:0044736	acid-sensing ion channel activity; TAS:Reactome.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9NY37	HS
# HGNC	HGNC:17537	ASIC5
# InterPro	IPR001873	Na+channel_ASC
# KEGG_Brite	ko04040	Ion channels
# MIM	616693	gene
# Organism	ASIC5_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11690	PTHR11690
# PRINTS	PR01078	AMINACHANNEL
# Pfam	PF00858	ASC
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	ASIC5_HUMAN	Acid-sensing ion channel 5
# RefSeq	NP_059115	NM_017419.2
# SIMILARITY	Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC5 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	ASIC5_HUMAN	Cell membrane {ECO 0000269|PubMed 10767424}; Multi-pass membrane protein {ECO 0000269|PubMed 10767424}. 
# SUBUNIT	Homotrimer or heterotrimer with other ASIC proteins. {ECO	0000250}. 
# TCDB	1.A.6.1.11	the epithelial na(+) channel (enac) family
# TISSUE SPECIFICITY	Detected in small intestine, duodenum and jejunum. Detected at very low levels in testis and rectum. {ECO:0000269|PubMed	10767424}. 
# UCSC	uc003ipe	human
# eggNOG	ENOG410ZNFK	LUCA
# eggNOG	KOG4294	Eukaryota
BLAST	swissprot:ASIC5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ASIC5_HUMAN
BioCyc	ZFISH:ENSG00000023843-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000023843-MONOMER
COXPRESdb	51802	http://coxpresdb.jp/data/gene/51802.shtml
CleanEx	HS_ACCN5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ACCN5
DOI	10.1016/S0014-5793(00)01403-4	http://dx.doi.org/10.1016/S0014-5793(00)01403-4
EMBL	AJ252011	http://www.ebi.ac.uk/ena/data/view/AJ252011
EMBL	CH471056	http://www.ebi.ac.uk/ena/data/view/CH471056
Ensembl	ENST00000537611	http://www.ensembl.org/id/ENST00000537611
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015252	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015252
GO_function	GO:0044736	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044736
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ASIC5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ASIC5
GeneID	51802	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51802
GeneTree	ENSGT00760000119120	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119120
HGNC	HGNC:17537	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17537
HOGENOM	HOG000033777	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000033777&db=HOGENOM6
HOVERGEN	HBG095680	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG095680&db=HOVERGEN
HPA	HPA014903	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014903
HPA	HPA029444	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA029444
InParanoid	Q9NY37	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NY37
InterPro	IPR001873	http://www.ebi.ac.uk/interpro/entry/IPR001873
Jabion	51802	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=51802
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:51802	http://www.genome.jp/dbget-bin/www_bget?hsa:51802
KEGG_Orthology	KO:K04832	http://www.genome.jp/dbget-bin/www_bget?KO:K04832
MIM	616693	http://www.ncbi.nlm.nih.gov/omim/616693
OMA	TERKKFD	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TERKKFD
OrthoDB	EOG091G053J	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G053J
PANTHER	PTHR11690	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11690
PRINTS	PR01078	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01078
PSORT	swissprot:ASIC5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ASIC5_HUMAN
PSORT-B	swissprot:ASIC5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ASIC5_HUMAN
PSORT2	swissprot:ASIC5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ASIC5_HUMAN
Pfam	PF00858	http://pfam.xfam.org/family/PF00858
PharmGKB	PA134946702	http://www.pharmgkb.org/do/serve?objId=PA134946702&objCls=Gene
Phobius	swissprot:ASIC5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ASIC5_HUMAN
PhylomeDB	Q9NY37	http://phylomedb.org/?seqid=Q9NY37
ProteinModelPortal	Q9NY37	http://www.proteinmodelportal.org/query/uniprot/Q9NY37
PubMed	10767424	http://www.ncbi.nlm.nih.gov/pubmed/10767424
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_059115	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_059115
SMR	Q9NY37	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9NY37
STRING	9606.ENSP00000442477	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000442477&targetmode=cogs
TCDB	1.A.6.1.11	http://www.tcdb.org/search/result.php?tc=1.A.6.1.11
UCSC	uc003ipe	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ipe&org=rat
UniGene	Hs.381349	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.381349
UniProtKB	ASIC5_HUMAN	http://www.uniprot.org/uniprot/ASIC5_HUMAN
UniProtKB-AC	Q9NY37	http://www.uniprot.org/uniprot/Q9NY37
charge	swissprot:ASIC5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ASIC5_HUMAN
eggNOG	ENOG410ZNFK	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZNFK
eggNOG	KOG4294	http://eggnogapi.embl.de/nog_data/html/tree/KOG4294
epestfind	swissprot:ASIC5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ASIC5_HUMAN
garnier	swissprot:ASIC5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ASIC5_HUMAN
helixturnhelix	swissprot:ASIC5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ASIC5_HUMAN
hmoment	swissprot:ASIC5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ASIC5_HUMAN
iep	swissprot:ASIC5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ASIC5_HUMAN
inforesidue	swissprot:ASIC5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ASIC5_HUMAN
neXtProt	NX_Q9NY37	http://www.nextprot.org/db/entry/NX_Q9NY37
octanol	swissprot:ASIC5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ASIC5_HUMAN
pepcoil	swissprot:ASIC5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ASIC5_HUMAN
pepdigest	swissprot:ASIC5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ASIC5_HUMAN
pepinfo	swissprot:ASIC5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ASIC5_HUMAN
pepnet	swissprot:ASIC5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ASIC5_HUMAN
pepstats	swissprot:ASIC5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ASIC5_HUMAN
pepwheel	swissprot:ASIC5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ASIC5_HUMAN
pepwindow	swissprot:ASIC5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ASIC5_HUMAN
sigcleave	swissprot:ASIC5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ASIC5_HUMAN
## Database	ID	URL or Descriptions
# AltName	VATL_HUMAN	Vacuolar proton pump 16 kDa proteolipid subunit
# BioGrid	107010	22
# Ensembl	ENST00000330398	ENSP00000329757; ENSG00000185883
# ExpressionAtlas	P27449	baseline and differential
# FUNCTION	VATL_HUMAN	Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. 
# GO_component	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain; IBA:GO_Central.
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005925	focal adhesion; IDA:UniProtKB.
# GO_component	GO:0010008	endosome membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_component	GO:0030670	phagocytic vesicle membrane; TAS:Reactome.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0031625	ubiquitin protein ligase binding; IPI:UniProtKB.
# GO_function	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism; TAS:UniProtKB.
# GO_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism; TAS:ProtInc.
# GO_process	GO:0007042	lysosomal lumen acidification; IBA:GO_Central.
# GO_process	GO:0008286	insulin receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0015991	ATP hydrolysis coupled proton transport; IEA:InterPro.
# GO_process	GO:0015992	proton transport; TAS:ProtInc.
# GO_process	GO:0016032	viral process; IEA:UniProtKB-KW.
# GO_process	GO:0016241	regulation of macroautophagy; NAS:ParkinsonsUK-UCL.
# GO_process	GO:0030177	positive regulation of Wnt signaling pathway; IMP:UniProtKB.
# GO_process	GO:0033572	transferrin transport; TAS:Reactome.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0090383	phagosome acidification; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P27449	HS
# HGNC	HGNC:855	ATP6V0C
# INTERACTION	VATL_HUMAN	Q96G23 CERS2; NbExp=3; IntAct=EBI-721179, EBI-1057080; P0CK45 E5 (xeno); NbExp=2; IntAct=EBI-721179, EBI-7015490; Q92838 EDA; NbExp=3; IntAct=EBI-721179, EBI-529425; P21757 MSR1; NbExp=3; IntAct=EBI-721179, EBI-1776976; P25788 PSMA3; NbExp=3; IntAct=EBI-721179, EBI-348380; Q9BZL3 SMIM3; NbExp=5; IntAct=EBI-721179, EBI-741850; 
# IntAct	P27449	13
# InterPro	IPR000245	ATPase_proteolipid_csu
# InterPro	IPR002379	ATPase_proteolipid_c-like_dom
# InterPro	IPR011555	ATPase_proteolipid_su_C_euk
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04142	Lysosome
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04966	Collecting duct acid secretion
# KEGG_Pathway	ko05110	Vibrio cholerae infection
# KEGG_Pathway	ko05120	Epithelial cell signaling in Helicobacter pylori infection
# KEGG_Pathway	ko05152	Tuberculosis
# KEGG_Pathway	ko05323	Rheumatoid arthritis
# MIM	108745	gene
# Organism	VATL_HUMAN	Homo sapiens (Human)
# PIR	A39367	A39367
# PRINTS	PR00122	VACATPASE
# PTM	VATL_HUMAN	Ubiquitinated by RNF182, leading to its degradation via the ubiquitin-proteasome pathway. {ECO 0000269|PubMed 18298843}. 
# Pfam	PF00137	ATP-synt_C; 2
# Proteomes	UP000005640	Chromosome 16
# Reactome	R-HSA-1222556	ROS, RNS production in response to bacteria
# Reactome	R-HSA-6798695	Neutrophil degranulation
# Reactome	R-HSA-77387	Insulin receptor recycling
# Reactome	R-HSA-917977	Transferrin endocytosis and recycling
# Reactome	R-HSA-983712	Ion channel transport
# RecName	VATL_HUMAN	V-type proton ATPase 16 kDa proteolipid subunit
# RefSeq	NP_001185498	NM_001198569.1
# RefSeq	NP_001685	NM_001694.3
# SIMILARITY	Belongs to the V-ATPase proteolipid subunit family. {ECO	0000305}.
# SUBCELLULAR LOCATION	VATL_HUMAN	Vacuole membrane; Multi-pass membrane protein. 
# SUBUNIT	VATL_HUMAN	V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components  subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component  the proteolipid protein; which is present as a hexamer that forms the proton-conducting pore). Interacts with LASS2. Interacts with HTLV-1 accessory protein p12I. Interacts with RNF182; this interaction leads to ubiquitination and degradation via the proteasome pathway. {ECO 0000269|PubMed 11543633, ECO 0000269|PubMed 18298843, ECO 0000269|PubMed 7636472}. 
# SUPFAM	SSF81333	SSF81333; 2
# TIGRFAMs	TIGR01100	V_ATP_synt_C
# UCSC	uc002cqn	human
# eggNOG	COG0636	LUCA
# eggNOG	KOG0232	Eukaryota
BLAST	swissprot:VATL_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VATL_HUMAN
BioCyc	MetaCyc:MONOMER66-34368	http://biocyc.org/getid?id=MetaCyc:MONOMER66-34368
BioCyc	ZFISH:MONOMER66-34368	http://biocyc.org/getid?id=ZFISH:MONOMER66-34368
COG	COG0636	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0636
COXPRESdb	527	http://coxpresdb.jp/data/gene/527.shtml
CleanEx	HS_ATP6V0C	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP6V0C
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/geno.2001.6614	http://dx.doi.org/10.1006/geno.2001.6614
DOI	10.1016/0006-291X(92)90562-Y	http://dx.doi.org/10.1016/0006-291X(92)90562-Y
DOI	10.1073/pnas.88.10.4289	http://dx.doi.org/10.1073/pnas.88.10.4289
DOI	10.1099/0022-1317-76-8-1909	http://dx.doi.org/10.1099/0022-1317-76-8-1909
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1750-1326-3-4	http://dx.doi.org/10.1186/1750-1326-3-4
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	BC004537	http://www.ebi.ac.uk/ena/data/view/BC004537
EMBL	BC007389	http://www.ebi.ac.uk/ena/data/view/BC007389
EMBL	BC007759	http://www.ebi.ac.uk/ena/data/view/BC007759
EMBL	BC009290	http://www.ebi.ac.uk/ena/data/view/BC009290
EMBL	BT007155	http://www.ebi.ac.uk/ena/data/view/BT007155
EMBL	CR541930	http://www.ebi.ac.uk/ena/data/view/CR541930
EMBL	CR541951	http://www.ebi.ac.uk/ena/data/view/CR541951
EMBL	M62762	http://www.ebi.ac.uk/ena/data/view/M62762
Ensembl	ENST00000330398	http://www.ensembl.org/id/ENST00000330398
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000220
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005925	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005925
GO_component	GO:0010008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010008
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030670	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030670
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0031625	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031625
GO_function	GO:0046933	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046933
GO_function	GO:0046961	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046961
GO_process	GO:0007042	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007042
GO_process	GO:0008286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008286
GO_process	GO:0015991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015991
GO_process	GO:0015992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992
GO_process	GO:0016032	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016032
GO_process	GO:0016241	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016241
GO_process	GO:0030177	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030177
GO_process	GO:0033572	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033572
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0090383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090383
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ATP6V0C	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP6V0C
GeneID	527	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=527
GeneTree	ENSGT00550000074873	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074873
HGNC	HGNC:855	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:855
HOGENOM	HOG000056520	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000056520&db=HOGENOM6
HOVERGEN	HBG002712	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG002712&db=HOVERGEN
InParanoid	P27449	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27449
IntAct	P27449	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P27449*
InterPro	IPR000245	http://www.ebi.ac.uk/interpro/entry/IPR000245
InterPro	IPR002379	http://www.ebi.ac.uk/interpro/entry/IPR002379
InterPro	IPR011555	http://www.ebi.ac.uk/interpro/entry/IPR011555
Jabion	527	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=527
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:527	http://www.genome.jp/dbget-bin/www_bget?hsa:527
KEGG_Orthology	KO:K02155	http://www.genome.jp/dbget-bin/www_bget?KO:K02155
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04142	http://www.genome.jp/kegg-bin/show_pathway?ko04142
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04966	http://www.genome.jp/kegg-bin/show_pathway?ko04966
KEGG_Pathway	ko05110	http://www.genome.jp/kegg-bin/show_pathway?ko05110
KEGG_Pathway	ko05120	http://www.genome.jp/kegg-bin/show_pathway?ko05120
KEGG_Pathway	ko05152	http://www.genome.jp/kegg-bin/show_pathway?ko05152
KEGG_Pathway	ko05323	http://www.genome.jp/kegg-bin/show_pathway?ko05323
MIM	108745	http://www.ncbi.nlm.nih.gov/omim/108745
MINT	MINT-1414327	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1414327
OMA	TCAIVFT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TCAIVFT
OrthoDB	EOG091G0U1Y	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0U1Y
PRINTS	PR00122	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00122
PSORT	swissprot:VATL_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VATL_HUMAN
PSORT-B	swissprot:VATL_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VATL_HUMAN
PSORT2	swissprot:VATL_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VATL_HUMAN
Pfam	PF00137	http://pfam.xfam.org/family/PF00137
PharmGKB	PA25149	http://www.pharmgkb.org/do/serve?objId=PA25149&objCls=Gene
Phobius	swissprot:VATL_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VATL_HUMAN
PhylomeDB	P27449	http://phylomedb.org/?seqid=P27449
ProteinModelPortal	P27449	http://www.proteinmodelportal.org/query/uniprot/P27449
PubMed	11543633	http://www.ncbi.nlm.nih.gov/pubmed/11543633
PubMed	1532310	http://www.ncbi.nlm.nih.gov/pubmed/1532310
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	1709739	http://www.ncbi.nlm.nih.gov/pubmed/1709739
PubMed	18298843	http://www.ncbi.nlm.nih.gov/pubmed/18298843
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	7636472	http://www.ncbi.nlm.nih.gov/pubmed/7636472
Reactome	R-HSA-1222556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1222556
Reactome	R-HSA-6798695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6798695
Reactome	R-HSA-77387	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-77387
Reactome	R-HSA-917977	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917977
Reactome	R-HSA-983712	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983712
RefSeq	NP_001185498	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001185498
RefSeq	NP_001685	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001685
SMR	P27449	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P27449
STRING	9606.ENSP00000329757	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000329757&targetmode=cogs
STRING	COG0636	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0636&targetmode=cogs
SUPFAM	SSF81333	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81333
TIGRFAMs	TIGR01100	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01100
UCSC	uc002cqn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002cqn&org=rat
UniGene	Hs.389107	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.389107
UniProtKB	VATL_HUMAN	http://www.uniprot.org/uniprot/VATL_HUMAN
UniProtKB-AC	P27449	http://www.uniprot.org/uniprot/P27449
charge	swissprot:VATL_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VATL_HUMAN
eggNOG	COG0636	http://eggnogapi.embl.de/nog_data/html/tree/COG0636
eggNOG	KOG0232	http://eggnogapi.embl.de/nog_data/html/tree/KOG0232
epestfind	swissprot:VATL_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VATL_HUMAN
garnier	swissprot:VATL_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VATL_HUMAN
helixturnhelix	swissprot:VATL_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VATL_HUMAN
hmoment	swissprot:VATL_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VATL_HUMAN
iep	swissprot:VATL_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VATL_HUMAN
inforesidue	swissprot:VATL_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VATL_HUMAN
neXtProt	NX_P27449	http://www.nextprot.org/db/entry/NX_P27449
octanol	swissprot:VATL_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VATL_HUMAN
pepcoil	swissprot:VATL_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VATL_HUMAN
pepdigest	swissprot:VATL_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VATL_HUMAN
pepinfo	swissprot:VATL_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VATL_HUMAN
pepnet	swissprot:VATL_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VATL_HUMAN
pepstats	swissprot:VATL_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VATL_HUMAN
pepwheel	swissprot:VATL_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VATL_HUMAN
pepwindow	swissprot:VATL_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VATL_HUMAN
sigcleave	swissprot:VATL_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VATL_HUMAN
## Database	ID	URL or Descriptions
# AltName	CXB2_HUMAN	Connexin-26
# BioGrid	108972	19
# CAUTION	CXB2_HUMAN	The Thr-34 allele was originally thought to be a cause of autosomal dominant and recessive deafness (DFNA3 and DFNB1) (PubMed 9139825). However, Thr-34 effect on hearing is controversial. Some studies supports its pathogenic role (PubMed 17935238 and PubMed 16849369). Others provide evidence of the non-pathogenic nature of this variant (PubMed 9422505 and PubMed 14694360). {ECO 0000305|PubMed 9139825}. 
# DISEASE	CXB2_HUMAN	Bart-Pumphrey syndrome (BPS) [MIM 149200]  An autosomal dominant disorder characterized by sensorineural hearing loss, palmoplantar keratoderma, knuckle pads, and leukonychia, It shows considerable phenotypic variability. {ECO 0000269|PubMed 15482471, ECO 0000269|PubMed 15952212}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CXB2_HUMAN	Deafness, autosomal dominant, 3A (DFNA3A) [MIM 601544]  A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO 0000269|PubMed 10807696, ECO 0000269|PubMed 11313763, ECO 0000269|PubMed 11439000, ECO 0000269|PubMed 12786758, ECO 0000269|PubMed 19384972, ECO 0000269|PubMed 9620796}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CXB2_HUMAN	Deafness, autosomal recessive, 1A (DFNB1A) [MIM 220290]  A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO 0000269|PubMed 10830906, ECO 0000269|PubMed 11313763, ECO 0000269|PubMed 11439000, ECO 0000269|PubMed 12121355, ECO 0000269|PubMed 12239718, ECO 0000269|PubMed 12786758, ECO 0000269|PubMed 14722929, ECO 0000269|PubMed 15666300, ECO 0000269|PubMed 15994881, ECO 0000269|PubMed 17660464, ECO 0000269|PubMed 17666888, ECO 0000269|PubMed 19384972, ECO 0000269|PubMed 23680645, ECO 0000269|PubMed 9328482, ECO 0000269|PubMed 9336442, ECO 0000269|PubMed 9471561, ECO 0000269|PubMed 9529365}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CXB2_HUMAN	Ichthyosis hystrix-like with deafness syndrome (HID syndrome) [MIM 602540]  An autosomal dominant keratinizing disorder characterized by sensorineural deafness and spiky hyperkeratosis affecting the entire skin. HID syndrome is considered to differ from the similar KID syndrome in the extent and time of occurrence of skin symptoms and the severity of the associated keratitis. {ECO 0000269|PubMed 12072059}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CXB2_HUMAN	Keratitis-ichthyosis-deafness syndrome (KID syndrome) [MIM 148210]  An autosomal dominant form of ectodermal dysplasia. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Keratitis-ichthyosis-deafness syndrome is characterized by the association of hyperkeratotic skin lesions with vascularizing keratitis and profound sensorineural hearing loss. Clinical features include deafness, ichthyosis, photophobia, absent or decreased eyebrows, sparse or absent scalp hair, decreased sweating and dysplastic finger and toenails. {ECO 0000269|PubMed 11912510, ECO 0000269|PubMed 12548749, ECO 0000269|PubMed 12752120}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CXB2_HUMAN	Keratoderma, palmoplantar, with deafness (PPKDFN) [MIM 148350]  An autosomal dominant disorder characterized by the association of palmoplantar hyperkeratosis with progressive, bilateral, high-frequency, sensorineural deafness. {ECO 0000269|PubMed 10633135, ECO 0000269|PubMed 10757647, ECO 0000269|PubMed 12372058, ECO 0000269|PubMed 15996214, ECO 0000269|PubMed 17993581, ECO 0000269|PubMed 9856479}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CXB2_HUMAN	Vohwinkel syndrome (VOWNKL) [MIM 124500]  An autosomal dominant disease characterized by hyperkeratosis, constriction on fingers and toes and congenital deafness. {ECO 0000269|PubMed 10369869, ECO 0000269|PubMed 15954104, ECO 0000269|PubMed 18688874}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000382844	ENSP00000372295; ENSG00000165474
# Ensembl	ENST00000382848	ENSP00000372299; ENSG00000165474
# ExpressionAtlas	P29033	baseline and differential
# FUNCTION	CXB2_HUMAN	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. 
# GO_component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment; TAS:Reactome.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005922	connexin complex; TAS:ProtInc.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0016328	lateral plasma membrane; IEA:Ensembl.
# GO_function	GO:0005243	gap junction channel activity; IEA:Ensembl.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007267	cell-cell signaling; TAS:ProtInc.
# GO_process	GO:0007605	sensory perception of sound; TAS:ProtInc.
# GO_process	GO:0016264	gap junction assembly; TAS:Reactome.
# GO_process	GO:0030539	male genitalia development; IEA:Ensembl.
# GO_process	GO:0032355	response to estradiol; IEA:Ensembl.
# GO_process	GO:0032570	response to progesterone; IEA:Ensembl.
# GO_process	GO:0034599	cellular response to oxidative stress; IEA:Ensembl.
# GO_process	GO:0044752	response to human chorionic gonadotropin; IEA:Ensembl.
# GO_process	GO:0046697	decidualization; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0022607	cellular component assembly
# GOslim_process	GO:0034330	cell junction organization
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# Genevisible	P29033	HS
# HGNC	HGNC:4284	GJB2
# IntAct	P29033	14
# InterPro	IPR000500	Connexin
# InterPro	IPR002268	Connexin26
# InterPro	IPR013092	Connexin_N
# InterPro	IPR017990	Connexin_CS
# InterPro	IPR019570	Connexin_CCC
# KEGG_Disease	H00604	[Nervous system disease; Nervous system disease] Deafness, autosomal dominant
# KEGG_Disease	H00605	[Nervous system disease; Nervous system disease] Deafness, autosomal recessive
# KEGG_Disease	H00706	[Nervous system disease; Skin and connective tissue disease] Bart-Pumphrey syndrome
# KEGG_Disease	H00712	[Skin and connective tissue disease; Nervous system disease] KID/HID syndrome
# KEGG_Disease	H00714	[Skin and connective tissue disease] Vohwinkel syndrome with ichthyosis
# KEGG_Disease	H00716	[Skin and connective tissue disease; Nervous system disease] Palmoplantar keratoderma with deafness
# KEGG_Disease	H01673	[Skin and connective tissue disease] Palmoplantar keratoderma
# MIM	121011	gene
# MIM	124500	phenotype
# MIM	148210	phenotype
# MIM	148350	phenotype
# MIM	149200	phenotype
# MIM	220290	phenotype
# MIM	601544	phenotype
# MIM	602540	phenotype
# Organism	CXB2_HUMAN	Homo sapiens (Human)
# Orphanet	166286	Porokeratotic eccrine ostial and dermal duct nevus
# Orphanet	2202	Palmoplantar keratoderma-deafness syndrome
# Orphanet	2698	Knuckle pads-leukonychia-sensorineural deafness-palmoplantar hyperkeratosis syndrome
# Orphanet	330029	Hypotrichosis-deafness syndrome
# Orphanet	477	KID syndrome
# Orphanet	494	Keratoderma hereditarium mutilans
# Orphanet	90635	Autosomal dominant non-syndromic sensorineural deafness type DFNA
# Orphanet	90636	Autosomal recessive non-syndromic sensorineural deafness type DFNB
# PANTHER	PTHR11984	PTHR11984
# PDB	1XIR	Model; -; A=1-226
# PDB	2ZW3	X-ray; 3.50 A; A/B/C/D/E/F=1-226
# PDB	3IZ1	EM; -; A/B/C=1-226
# PDB	3IZ2	EM; -; A/B/C=8-226
# PDB	5ER7	X-ray; 3.29 A; A/B=1-226
# PDB	5ERA	X-ray; 3.80 A; A/B=1-226
# PDB	5KJ3	NMR; -; A=1-22
# PDB	5KJG	NMR; -; A=1-22
# PIR	A43424	A43424
# PRINTS	PR00206	CONNEXIN
# PRINTS	PR01139	CONNEXINB2
# PROSITE	PS00407	CONNEXINS_1
# PROSITE	PS00408	CONNEXINS_2
# Pfam	PF00029	Connexin
# Proteomes	UP000005640	Chromosome 13
# Reactome	R-HSA-190704	Oligomerization of connexins into connexons
# Reactome	R-HSA-190827	Transport of connexins along the secretory pathway
# Reactome	R-HSA-190861	Gap junction assembly
# Reactome	R-HSA-190872	Transport of connexons to the plasma membrane
# RecName	CXB2_HUMAN	Gap junction beta-2 protein
# RefSeq	NP_003995	NM_004004.5
# RefSeq	XP_011533351	XM_011535049.2
# SIMILARITY	Belongs to the connexin family. Beta-type (group I) subfamily. {ECO	0000305}. 
# SMART	SM00037	CNX
# SMART	SM01089	Connexin_CCC
# SUBCELLULAR LOCATION	CXB2_HUMAN	Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. 
# SUBUNIT	A connexon is composed of a hexamer of connexins. Interacts with CNST (By similarity). {ECO	0000250}. 
# TCDB	1.A.24.1	the gap junction-forming connexin (connexin) family
# UCSC	uc001umy	human
# WEB RESOURCE	CXB2_HUMAN	Name=Connexin-deafness homepage; URL="http //davinci.crg.es/deafness/"; 
# WEB RESOURCE	CXB2_HUMAN	Name=Hereditary hearing loss homepage; Note=Gene page; URL="http //hereditaryhearingloss.org/main.aspx?c=.HHH&n=86162";
# eggNOG	ENOG410IFM8	Eukaryota
# eggNOG	ENOG410Y7VN	LUCA
BLAST	swissprot:CXB2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CXB2_HUMAN
BioCyc	ZFISH:ENSG00000165474-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000165474-MONOMER
COXPRESdb	2706	http://coxpresdb.jp/data/gene/2706.shtml
DIP	DIP-59742N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-59742N
DOI	10.1002/(SICI)1096-8628(20000117)90:2<141::AID-AJMG10>3.0.CO	http://dx.doi.org/10.1002/(SICI)1096-8628(20000117)90:2<141::AID-AJMG10>3.0.CO
DOI	10.1002/(SICI)1098-1004(1998)11:5<387::AID-HUMU6>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1998)11:5<387::AID-HUMU6>3.0.CO
DOI	10.1002/ajmg.10621	http://dx.doi.org/10.1002/ajmg.10621
DOI	10.1002/ajmg.a.10851	http://dx.doi.org/10.1002/ajmg.a.10851
DOI	10.1002/ajmg.a.30576	http://dx.doi.org/10.1002/ajmg.a.30576
DOI	10.1002/ajmg.a.30822	http://dx.doi.org/10.1002/ajmg.a.30822
DOI	10.1002/ajmg.a.31982	http://dx.doi.org/10.1002/ajmg.a.31982
DOI	10.1002/ajmg.a.32462	http://dx.doi.org/10.1002/ajmg.a.32462
DOI	10.1002/ajmg.a.32765	http://dx.doi.org/10.1002/ajmg.a.32765
DOI	10.1002/humu.1156	http://dx.doi.org/10.1002/humu.1156
DOI	10.1002/humu.21036	http://dx.doi.org/10.1002/humu.21036
DOI	10.1002/humu.9216	http://dx.doi.org/10.1002/humu.9216
DOI	10.1002/humu.9350	http://dx.doi.org/10.1002/humu.9350
DOI	10.1007/s00439-002-0889-x	http://dx.doi.org/10.1007/s00439-002-0889-x
DOI	10.1007/s004390000273	http://dx.doi.org/10.1007/s004390000273
DOI	10.1007/s004390050839	http://dx.doi.org/10.1007/s004390050839
DOI	10.1016/j.gene.2013.04.078	http://dx.doi.org/10.1016/j.gene.2013.04.078
DOI	10.1034/j.1399-0004.2002.610611.x	http://dx.doi.org/10.1034/j.1399-0004.2002.610611.x
DOI	10.1034/j.1399-0004.2002.620409.x	http://dx.doi.org/10.1034/j.1399-0004.2002.620409.x
DOI	10.1034/j.1399-0004.2003.00079.x	http://dx.doi.org/10.1034/j.1399-0004.2003.00079.x
DOI	10.1038/30639	http://dx.doi.org/10.1038/30639
DOI	10.1038/34079	http://dx.doi.org/10.1038/34079
DOI	10.1038/387080a0	http://dx.doi.org/10.1038/387080a0
DOI	10.1038/nature02379	http://dx.doi.org/10.1038/nature02379
DOI	10.1038/nature07869	http://dx.doi.org/10.1038/nature07869
DOI	10.1038/ncb1205	http://dx.doi.org/10.1038/ncb1205
DOI	10.1038/sj.ejhg.5200407	http://dx.doi.org/10.1038/sj.ejhg.5200407
DOI	10.1038/sj.ejhg.5200607	http://dx.doi.org/10.1038/sj.ejhg.5200607
DOI	10.1038/sj.ejhg.5201147	http://dx.doi.org/10.1038/sj.ejhg.5201147
DOI	10.1046/j.1365-2133.2002.04893.x	http://dx.doi.org/10.1046/j.1365-2133.2002.04893.x
DOI	10.1046/j.1365-2133.2003.05245.x	http://dx.doi.org/10.1046/j.1365-2133.2003.05245.x
DOI	10.1056/NEJM199802193380813	http://dx.doi.org/10.1056/NEJM199802193380813
DOI	10.1083/jcb.118.5.1213	http://dx.doi.org/10.1083/jcb.118.5.1213
DOI	10.1086/301807	http://dx.doi.org/10.1086/301807
DOI	10.1086/339986	http://dx.doi.org/10.1086/339986
DOI	10.1093/hmg/6.12.2163	http://dx.doi.org/10.1093/hmg/6.12.2163
DOI	10.1093/hmg/6.12.2173	http://dx.doi.org/10.1093/hmg/6.12.2173
DOI	10.1093/hmg/8.7.1237	http://dx.doi.org/10.1093/hmg/8.7.1237
DOI	10.1093/hmg/ddg076	http://dx.doi.org/10.1093/hmg/ddg076
DOI	10.1093/hmg/ddl184	http://dx.doi.org/10.1093/hmg/ddl184
DOI	10.1097/GIM.0b013e3180a03276	http://dx.doi.org/10.1097/GIM.0b013e3180a03276
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.0022-202X.2004.23470.x	http://dx.doi.org/10.1111/j.0022-202X.2004.23470.x
DOI	10.1111/j.1365-2133.2009.09137.x	http://dx.doi.org/10.1111/j.1365-2133.2009.09137.x
DOI	10.1111/j.1399-0004.2005.00468.x	http://dx.doi.org/10.1111/j.1399-0004.2005.00468.x
DOI	10.1136/jmg.2004.028324	http://dx.doi.org/10.1136/jmg.2004.028324
DOI	10.1136/jmg.2007.050682	http://dx.doi.org/10.1136/jmg.2007.050682
DOI	10.1136/jmg.2007.052332	http://dx.doi.org/10.1136/jmg.2007.052332
DOI	10.1136/jmg.37.1.50	http://dx.doi.org/10.1136/jmg.37.1.50
DOI	10.1136/jmg.37.5.368	http://dx.doi.org/10.1136/jmg.37.5.368
DOI	10.1136/jmg.40.5.e68	http://dx.doi.org/10.1136/jmg.40.5.e68
EMBL	AF281280	http://www.ebi.ac.uk/ena/data/view/AF281280
EMBL	AF479776	http://www.ebi.ac.uk/ena/data/view/AF479776
EMBL	AL138688	http://www.ebi.ac.uk/ena/data/view/AL138688
EMBL	AY255853	http://www.ebi.ac.uk/ena/data/view/AY255853
EMBL	AY275646	http://www.ebi.ac.uk/ena/data/view/AY275646
EMBL	AY275647	http://www.ebi.ac.uk/ena/data/view/AY275647
EMBL	AY275648	http://www.ebi.ac.uk/ena/data/view/AY275648
EMBL	AY275649	http://www.ebi.ac.uk/ena/data/view/AY275649
EMBL	AY275650	http://www.ebi.ac.uk/ena/data/view/AY275650
EMBL	AY275651	http://www.ebi.ac.uk/ena/data/view/AY275651
EMBL	AY275652	http://www.ebi.ac.uk/ena/data/view/AY275652
EMBL	AY275653	http://www.ebi.ac.uk/ena/data/view/AY275653
EMBL	AY275654	http://www.ebi.ac.uk/ena/data/view/AY275654
EMBL	AY280971	http://www.ebi.ac.uk/ena/data/view/AY280971
EMBL	AY953438	http://www.ebi.ac.uk/ena/data/view/AY953438
EMBL	AY953441	http://www.ebi.ac.uk/ena/data/view/AY953441
EMBL	BC017048	http://www.ebi.ac.uk/ena/data/view/BC017048
EMBL	BC071703	http://www.ebi.ac.uk/ena/data/view/BC071703
EMBL	BT006732	http://www.ebi.ac.uk/ena/data/view/BT006732
EMBL	M86849	http://www.ebi.ac.uk/ena/data/view/M86849
Ensembl	ENST00000382844	http://www.ensembl.org/id/ENST00000382844
Ensembl	ENST00000382848	http://www.ensembl.org/id/ENST00000382848
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005793	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005793
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005922	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005922
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016328
GO_function	GO:0005243	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005243
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GO_process	GO:0007605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007605
GO_process	GO:0016264	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016264
GO_process	GO:0030539	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030539
GO_process	GO:0032355	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032355
GO_process	GO:0032570	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032570
GO_process	GO:0034599	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034599
GO_process	GO:0044752	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044752
GO_process	GO:0046697	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046697
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0022607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607
GOslim_process	GO:0034330	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034330
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	GJB2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GJB2
GeneID	2706	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2706
GeneTree	ENSGT00860000133694	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00860000133694
HGNC	HGNC:4284	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4284
HOVERGEN	HBG009576	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG009576&db=HOVERGEN
HPA	CAB013093	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB013093
InParanoid	P29033	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P29033
IntAct	P29033	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P29033*
InterPro	IPR000500	http://www.ebi.ac.uk/interpro/entry/IPR000500
InterPro	IPR002268	http://www.ebi.ac.uk/interpro/entry/IPR002268
InterPro	IPR013092	http://www.ebi.ac.uk/interpro/entry/IPR013092
InterPro	IPR017990	http://www.ebi.ac.uk/interpro/entry/IPR017990
InterPro	IPR019570	http://www.ebi.ac.uk/interpro/entry/IPR019570
Jabion	2706	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2706
KEGG_Disease	H00604	http://www.genome.jp/dbget-bin/www_bget?H00604
KEGG_Disease	H00605	http://www.genome.jp/dbget-bin/www_bget?H00605
KEGG_Disease	H00706	http://www.genome.jp/dbget-bin/www_bget?H00706
KEGG_Disease	H00712	http://www.genome.jp/dbget-bin/www_bget?H00712
KEGG_Disease	H00714	http://www.genome.jp/dbget-bin/www_bget?H00714
KEGG_Disease	H00716	http://www.genome.jp/dbget-bin/www_bget?H00716
KEGG_Disease	H01673	http://www.genome.jp/dbget-bin/www_bget?H01673
KEGG_Gene	hsa:2706	http://www.genome.jp/dbget-bin/www_bget?hsa:2706
KEGG_Orthology	KO:K07621	http://www.genome.jp/dbget-bin/www_bget?KO:K07621
MIM	121011	http://www.ncbi.nlm.nih.gov/omim/121011
MIM	124500	http://www.ncbi.nlm.nih.gov/omim/124500
MIM	148210	http://www.ncbi.nlm.nih.gov/omim/148210
MIM	148350	http://www.ncbi.nlm.nih.gov/omim/148350
MIM	149200	http://www.ncbi.nlm.nih.gov/omim/149200
MIM	220290	http://www.ncbi.nlm.nih.gov/omim/220290
MIM	601544	http://www.ncbi.nlm.nih.gov/omim/601544
MIM	602540	http://www.ncbi.nlm.nih.gov/omim/602540
OMA	VMYDGFA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VMYDGFA
Orphanet	166286	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=166286
Orphanet	2202	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=2202
Orphanet	2698	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=2698
Orphanet	330029	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=330029
Orphanet	477	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=477
Orphanet	494	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=494
Orphanet	90635	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=90635
Orphanet	90636	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=90636
OrthoDB	EOG091G0FKH	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0FKH
PANTHER	PTHR11984	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11984
PDB	1XIR	http://www.ebi.ac.uk/pdbe-srv/view/entry/1XIR
PDB	2ZW3	http://www.ebi.ac.uk/pdbe-srv/view/entry/2ZW3
PDB	3IZ1	http://www.ebi.ac.uk/pdbe-srv/view/entry/3IZ1
PDB	3IZ2	http://www.ebi.ac.uk/pdbe-srv/view/entry/3IZ2
PDB	5ER7	http://www.ebi.ac.uk/pdbe-srv/view/entry/5ER7
PDB	5ERA	http://www.ebi.ac.uk/pdbe-srv/view/entry/5ERA
PDB	5KJ3	http://www.ebi.ac.uk/pdbe-srv/view/entry/5KJ3
PDB	5KJG	http://www.ebi.ac.uk/pdbe-srv/view/entry/5KJG
PDBsum	1XIR	http://www.ebi.ac.uk/pdbsum/1XIR
PDBsum	2ZW3	http://www.ebi.ac.uk/pdbsum/2ZW3
PDBsum	3IZ1	http://www.ebi.ac.uk/pdbsum/3IZ1
PDBsum	3IZ2	http://www.ebi.ac.uk/pdbsum/3IZ2
PDBsum	5ER7	http://www.ebi.ac.uk/pdbsum/5ER7
PDBsum	5ERA	http://www.ebi.ac.uk/pdbsum/5ERA
PDBsum	5KJ3	http://www.ebi.ac.uk/pdbsum/5KJ3
PDBsum	5KJG	http://www.ebi.ac.uk/pdbsum/5KJG
PRINTS	PR00206	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00206
PRINTS	PR01139	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01139
PROSITE	PS00407	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00407
PROSITE	PS00408	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00408
PSORT	swissprot:CXB2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CXB2_HUMAN
PSORT-B	swissprot:CXB2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CXB2_HUMAN
PSORT2	swissprot:CXB2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CXB2_HUMAN
Pfam	PF00029	http://pfam.xfam.org/family/PF00029
PharmGKB	PA28695	http://www.pharmgkb.org/do/serve?objId=PA28695&objCls=Gene
Phobius	swissprot:CXB2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CXB2_HUMAN
PhylomeDB	P29033	http://phylomedb.org/?seqid=P29033
ProteinModelPortal	P29033	http://www.proteinmodelportal.org/query/uniprot/P29033
PubMed	10369869	http://www.ncbi.nlm.nih.gov/pubmed/10369869
PubMed	10607953	http://www.ncbi.nlm.nih.gov/pubmed/10607953
PubMed	10633135	http://www.ncbi.nlm.nih.gov/pubmed/10633135
PubMed	10757647	http://www.ncbi.nlm.nih.gov/pubmed/10757647
PubMed	10807696	http://www.ncbi.nlm.nih.gov/pubmed/10807696
PubMed	10830906	http://www.ncbi.nlm.nih.gov/pubmed/10830906
PubMed	11313763	http://www.ncbi.nlm.nih.gov/pubmed/11313763
PubMed	11439000	http://www.ncbi.nlm.nih.gov/pubmed/11439000
PubMed	11912510	http://www.ncbi.nlm.nih.gov/pubmed/11912510
PubMed	12072059	http://www.ncbi.nlm.nih.gov/pubmed/12072059
PubMed	12121355	http://www.ncbi.nlm.nih.gov/pubmed/12121355
PubMed	12239718	http://www.ncbi.nlm.nih.gov/pubmed/12239718
PubMed	12372058	http://www.ncbi.nlm.nih.gov/pubmed/12372058
PubMed	12548749	http://www.ncbi.nlm.nih.gov/pubmed/12548749
PubMed	12560944	http://www.ncbi.nlm.nih.gov/pubmed/12560944
PubMed	12668604	http://www.ncbi.nlm.nih.gov/pubmed/12668604
PubMed	12746422	http://www.ncbi.nlm.nih.gov/pubmed/12746422
PubMed	12752120	http://www.ncbi.nlm.nih.gov/pubmed/12752120
PubMed	12786758	http://www.ncbi.nlm.nih.gov/pubmed/12786758
PubMed	1324944	http://www.ncbi.nlm.nih.gov/pubmed/1324944
PubMed	14694360	http://www.ncbi.nlm.nih.gov/pubmed/14694360
PubMed	14722929	http://www.ncbi.nlm.nih.gov/pubmed/14722929
PubMed	15057823	http://www.ncbi.nlm.nih.gov/pubmed/15057823
PubMed	15482471	http://www.ncbi.nlm.nih.gov/pubmed/15482471
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15592461	http://www.ncbi.nlm.nih.gov/pubmed/15592461
PubMed	15666300	http://www.ncbi.nlm.nih.gov/pubmed/15666300
PubMed	15952212	http://www.ncbi.nlm.nih.gov/pubmed/15952212
PubMed	15954104	http://www.ncbi.nlm.nih.gov/pubmed/15954104
PubMed	15994881	http://www.ncbi.nlm.nih.gov/pubmed/15994881
PubMed	15996214	http://www.ncbi.nlm.nih.gov/pubmed/15996214
PubMed	16849369	http://www.ncbi.nlm.nih.gov/pubmed/16849369
PubMed	17660464	http://www.ncbi.nlm.nih.gov/pubmed/17660464
PubMed	17666888	http://www.ncbi.nlm.nih.gov/pubmed/17666888
PubMed	17935238	http://www.ncbi.nlm.nih.gov/pubmed/17935238
PubMed	17993581	http://www.ncbi.nlm.nih.gov/pubmed/17993581
PubMed	18688874	http://www.ncbi.nlm.nih.gov/pubmed/18688874
PubMed	19283857	http://www.ncbi.nlm.nih.gov/pubmed/19283857
PubMed	19340074	http://www.ncbi.nlm.nih.gov/pubmed/19340074
PubMed	19384972	http://www.ncbi.nlm.nih.gov/pubmed/19384972
PubMed	19416251	http://www.ncbi.nlm.nih.gov/pubmed/19416251
PubMed	23680645	http://www.ncbi.nlm.nih.gov/pubmed/23680645
PubMed	9139825	http://www.ncbi.nlm.nih.gov/pubmed/9139825
PubMed	9328482	http://www.ncbi.nlm.nih.gov/pubmed/9328482
PubMed	9336442	http://www.ncbi.nlm.nih.gov/pubmed/9336442
PubMed	9422505	http://www.ncbi.nlm.nih.gov/pubmed/9422505
PubMed	9471561	http://www.ncbi.nlm.nih.gov/pubmed/9471561
PubMed	9529365	http://www.ncbi.nlm.nih.gov/pubmed/9529365
PubMed	9600457	http://www.ncbi.nlm.nih.gov/pubmed/9600457
PubMed	9620796	http://www.ncbi.nlm.nih.gov/pubmed/9620796
PubMed	9856479	http://www.ncbi.nlm.nih.gov/pubmed/9856479
Reactome	R-HSA-190704	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-190704
Reactome	R-HSA-190827	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-190827
Reactome	R-HSA-190861	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-190861
Reactome	R-HSA-190872	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-190872
RefSeq	NP_003995	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003995
RefSeq	XP_011533351	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011533351
SMART	SM00037	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00037
SMART	SM01089	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01089
SMR	P29033	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P29033
STRING	9606.ENSP00000372295	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000372295&targetmode=cogs
TCDB	1.A.24.1	http://www.tcdb.org/search/result.php?tc=1.A.24.1
UCSC	uc001umy	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001umy&org=rat
UniGene	Hs.524894	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.524894
UniGene	Hs.714494	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.714494
UniProtKB	CXB2_HUMAN	http://www.uniprot.org/uniprot/CXB2_HUMAN
UniProtKB-AC	P29033	http://www.uniprot.org/uniprot/P29033
charge	swissprot:CXB2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CXB2_HUMAN
eggNOG	ENOG410IFM8	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IFM8
eggNOG	ENOG410Y7VN	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y7VN
epestfind	swissprot:CXB2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CXB2_HUMAN
garnier	swissprot:CXB2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CXB2_HUMAN
helixturnhelix	swissprot:CXB2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CXB2_HUMAN
hmoment	swissprot:CXB2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CXB2_HUMAN
iep	swissprot:CXB2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CXB2_HUMAN
inforesidue	swissprot:CXB2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CXB2_HUMAN
neXtProt	NX_P29033	http://www.nextprot.org/db/entry/NX_P29033
octanol	swissprot:CXB2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CXB2_HUMAN
pepcoil	swissprot:CXB2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CXB2_HUMAN
pepdigest	swissprot:CXB2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CXB2_HUMAN
pepinfo	swissprot:CXB2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CXB2_HUMAN
pepnet	swissprot:CXB2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CXB2_HUMAN
pepstats	swissprot:CXB2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CXB2_HUMAN
pepwheel	swissprot:CXB2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CXB2_HUMAN
pepwindow	swissprot:CXB2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CXB2_HUMAN
sigcleave	swissprot:CXB2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CXB2_HUMAN
## Database	ID	URL or Descriptions
# AltName	QCR10_HUMAN	Complex III subunit 10
# AltName	QCR10_HUMAN	Complex III subunit XI
# AltName	QCR10_HUMAN	Ubiquinol-cytochrome c reductase complex 6.4 kDa protein
# BioGrid	116172	4
# ChiTaRS	UQCR11	human
# Ensembl	ENST00000585671	ENSP00000466420; ENSG00000127540
# Ensembl	ENST00000589880	ENSP00000467555; ENSG00000127540
# Ensembl	ENST00000591899	ENSP00000467262; ENSG00000127540
# FUNCTION	QCR10_HUMAN	This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. 
# FUNCTION	QCR10_HUMAN	This protein may be closely linked to the iron-sulfur protein in the complex and function as an iron-sulfur protein binding factor. 
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0070469	respiratory chain; IEA:UniProtKB-KW.
# GO_function	GO:0008121	ubiquinol-cytochrome-c reductase activity; IEA:InterPro.
# GO_function	GO:0009055	electron carrier activity; TAS:UniProtKB.
# GO_process	GO:0006091	generation of precursor metabolites and energy; TAS:ProtInc.
# GO_process	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# Gene3D	1.20.5.220	-; 1.
# Genevisible	O14957	HS
# HGNC	HGNC:30862	UQCR11
# InterPro	IPR015089	UQCR
# InterPro	IPR029027	Single_a-helix
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	609711	gene
# Organism	QCR10_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR15420	PTHR15420
# Pfam	PF08997	UCR_6-4kD
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-611105	Respiratory electron transport
# RecName	QCR10_HUMAN	Cytochrome b-c1 complex subunit 10
# RefSeq	NP_006821	NM_006830.3
# SIMILARITY	Belongs to the UQCR11/QCR10 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	QCR10_HUMAN	Mitochondrion inner membrane. 
# SUBUNIT	The bc1 complex contains 11 subunits	 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1). 
# SUPFAM	SSF81518	SSF81518
# UCSC	uc002ltm	human
# eggNOG	ENOG410J5Z0	Eukaryota
# eggNOG	ENOG410XVMI	LUCA
BLAST	swissprot:QCR10_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:QCR10_HUMAN
BioCyc	ZFISH:HS05111-MONOMER	http://biocyc.org/getid?id=ZFISH:HS05111-MONOMER
COXPRESdb	10975	http://coxpresdb.jp/data/gene/10975.shtml
CleanEx	HS_UQCR	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_UQCR
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC005321	http://www.ebi.ac.uk/ena/data/view/AC005321
EMBL	AC005943	http://www.ebi.ac.uk/ena/data/view/AC005943
EMBL	AK312053	http://www.ebi.ac.uk/ena/data/view/AK312053
EMBL	BC000462	http://www.ebi.ac.uk/ena/data/view/BC000462
EMBL	BC003594	http://www.ebi.ac.uk/ena/data/view/BC003594
EMBL	CH471139	http://www.ebi.ac.uk/ena/data/view/CH471139
EMBL	CH471139	http://www.ebi.ac.uk/ena/data/view/CH471139
EMBL	CH471139	http://www.ebi.ac.uk/ena/data/view/CH471139
EMBL	D55636	http://www.ebi.ac.uk/ena/data/view/D55636
Ensembl	ENST00000585671	http://www.ensembl.org/id/ENST00000585671
Ensembl	ENST00000589880	http://www.ensembl.org/id/ENST00000589880
Ensembl	ENST00000591899	http://www.ensembl.org/id/ENST00000591899
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0070469	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070469
GO_function	GO:0008121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008121
GO_function	GO:0009055	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055
GO_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GO_process	GO:0006122	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006122
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
Gene3D	1.20.5.220	http://www.cathdb.info/version/latest/superfamily/1.20.5.220
GeneCards	UQCR11	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=UQCR11
GeneID	10975	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10975
GeneTree	ENSGT00390000018299	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000018299
HGNC	HGNC:30862	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:30862
HOGENOM	HOG000030914	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000030914&db=HOGENOM6
HOVERGEN	HBG105467	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG105467&db=HOVERGEN
InParanoid	O14957	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O14957
IntAct	O14957	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O14957*
InterPro	IPR015089	http://www.ebi.ac.uk/interpro/entry/IPR015089
InterPro	IPR029027	http://www.ebi.ac.uk/interpro/entry/IPR029027
Jabion	10975	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10975
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Gene	hsa:10975	http://www.genome.jp/dbget-bin/www_bget?hsa:10975
KEGG_Orthology	KO:K00420	http://www.genome.jp/dbget-bin/www_bget?KO:K00420
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	609711	http://www.ncbi.nlm.nih.gov/omim/609711
OMA	GMWGAVG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GMWGAVG
OrthoDB	EOG091G1ATB	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G1ATB
PANTHER	PTHR15420	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15420
PSORT	swissprot:QCR10_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:QCR10_HUMAN
PSORT-B	swissprot:QCR10_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:QCR10_HUMAN
PSORT2	swissprot:QCR10_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:QCR10_HUMAN
Pfam	PF08997	http://pfam.xfam.org/family/PF08997
PharmGKB	PA165394505	http://www.pharmgkb.org/do/serve?objId=PA165394505&objCls=Gene
Phobius	swissprot:QCR10_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:QCR10_HUMAN
PhylomeDB	O14957	http://phylomedb.org/?seqid=O14957
ProteinModelPortal	O14957	http://www.proteinmodelportal.org/query/uniprot/O14957
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	9161705	http://www.ncbi.nlm.nih.gov/pubmed/9161705
Reactome	R-HSA-611105	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-611105
RefSeq	NP_006821	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006821
SMR	O14957	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O14957
STRING	9606.ENSP00000466420	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000466420&targetmode=cogs
SUPFAM	SSF81518	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81518
UCSC	uc002ltm	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ltm&org=rat
UniGene	Hs.8372	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.8372
UniProtKB	QCR10_HUMAN	http://www.uniprot.org/uniprot/QCR10_HUMAN
UniProtKB-AC	O14957	http://www.uniprot.org/uniprot/O14957
charge	swissprot:QCR10_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:QCR10_HUMAN
eggNOG	ENOG410J5Z0	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410J5Z0
eggNOG	ENOG410XVMI	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XVMI
epestfind	swissprot:QCR10_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:QCR10_HUMAN
garnier	swissprot:QCR10_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:QCR10_HUMAN
helixturnhelix	swissprot:QCR10_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:QCR10_HUMAN
hmoment	swissprot:QCR10_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:QCR10_HUMAN
iep	swissprot:QCR10_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:QCR10_HUMAN
inforesidue	swissprot:QCR10_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:QCR10_HUMAN
neXtProt	NX_O14957	http://www.nextprot.org/db/entry/NX_O14957
octanol	swissprot:QCR10_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:QCR10_HUMAN
pepcoil	swissprot:QCR10_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:QCR10_HUMAN
pepdigest	swissprot:QCR10_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:QCR10_HUMAN
pepinfo	swissprot:QCR10_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:QCR10_HUMAN
pepnet	swissprot:QCR10_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:QCR10_HUMAN
pepstats	swissprot:QCR10_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:QCR10_HUMAN
pepwheel	swissprot:QCR10_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:QCR10_HUMAN
pepwindow	swissprot:QCR10_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:QCR10_HUMAN
sigcleave	swissprot:QCR10_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:QCR10_HUMAN
## Database	ID	URL or Descriptions
# AltName	ARY2_HUMAN	Arylamide acetylase 2
# AltName	ARY2_HUMAN	N-acetyltransferase type 2
# AltName	ARY2_HUMAN	Polymorphic arylamine N-acetyltransferase
# BRENDA	2.3.1	2681
# BioGrid	106528	20
# CATALYTIC ACTIVITY	ARY2_HUMAN	Acetyl-CoA + an arylamine = CoA + an N- acetylarylamine. 
# DrugBank	DB00250	Dapsone
# DrugBank	DB00316	Acetaminophen
# DrugBank	DB00951	Isoniazid
# DrugBank	DB01015	Sulfamethoxazole
# DrugBank	DB01068	Clonazepam
# DrugBank	DB04953	Ezogabine
# Ensembl	ENST00000286479	ENSP00000286479; ENSG00000156006
# ExpressionAtlas	P11245	baseline and differential
# FUNCTION	ARY2_HUMAN	Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens. 
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0005886	plasma membrane; IEA:Ensembl.
# GO_function	GO:0004060	arylamine N-acetyltransferase activity; TAS:Reactome.
# GO_function	GO:0015179	L-amino acid transmembrane transporter activity; IEA:Ensembl.
# GO_process	GO:0006805	xenobiotic metabolic process; TAS:Reactome.
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0016746	transferase activity, transferring acyl groups
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# Genevisible	P11245	HS
# HGNC	HGNC:7646	NAT2
# INTERACTION	ARY2_HUMAN	Q13315 ATM; NbExp=2; IntAct=EBI-9057228, EBI-495465; Q06609 RAD51; NbExp=4; IntAct=EBI-9057228, EBI-297202; 
# IntAct	P11245	16
# InterPro	IPR001447	Arylamine_N-AcTrfase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00232	Caffeine metabolism
# KEGG_Pathway	ko00633	Nitrotoluene degradation
# KEGG_Pathway	ko00983	Drug metabolism - other enzymes
# KEGG_Pathway	ko05204	Chemical carcinogenesis
# MIM	243400	phenotype
# MIM	612182	gene
# Organism	ARY2_HUMAN	Homo sapiens (Human)
# Orphanet	240887	Isoniazid toxicity
# PANTHER	PTHR11786	PTHR11786
# PDB	2PFR	X-ray; 1.92 A; A/B=2-290
# PIR	B34585	B34585
# PIR	S02788	S02788
# POLYMORPHISM	Polymorphisms in NAT2 are the cause of slow and fast acetylation phenotypes [MIM:243400] and influence drug therapy response and susceptibility to chemical toxicity or carcinogenicity. {ECO	0000269|PubMed:16416399}. 
# PRINTS	PR01543	ANATRNSFRASE
# Pfam	PF00797	Acetyltransf_2
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-156582	Acetylation
# RecName	ARY2_HUMAN	Arylamine N-acetyltransferase 2
# RefSeq	NP_000006	NM_000015.2
# RefSeq	XP_016868427	XM_017012938.1
# SEQUENCE CAUTION	Sequence=AAK51711.1; Type=Frameshift; Positions=287; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the arylamine N-acetyltransferase family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	ARY2_HUMAN	Cytoplasm. 
# UCSC	uc003wyw	human
# WEB RESOURCE	ARY2_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/NAT2ID41498ch8p22.html"; 
# WEB RESOURCE	ARY2_HUMAN	Name=NAT; Note=NAT alleles; URL="http //nat.mbg.duth.gr/"; 
# WEB RESOURCE	ARY2_HUMAN	Name=NIEHS-SNPs; URL="http //egp.gs.washington.edu/data/nat2/"; 
# WEB RESOURCE	ARY2_HUMAN	Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http //shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=NAT2";
# eggNOG	COG2162	LUCA
# eggNOG	ENOG410IFD6	Eukaryota
BLAST	swissprot:ARY2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ARY2_HUMAN
BioCyc	ZFISH:HS08090-MONOMER	http://biocyc.org/getid?id=ZFISH:HS08090-MONOMER
COG	COG2162	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2162
COXPRESdb	10	http://coxpresdb.jp/data/gene/10.shtml
CleanEx	HS_NAT2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_NAT2
DOI	10.1006/bbrc.1993.1289	http://dx.doi.org/10.1006/bbrc.1993.1289
DOI	10.1016/0006-291X(91)90676-X	http://dx.doi.org/10.1016/0006-291X(91)90676-X
DOI	10.1016/0014-5793(89)81193-7	http://dx.doi.org/10.1016/0014-5793(89)81193-7
DOI	10.1038/nature04406	http://dx.doi.org/10.1038/nature04406
DOI	10.1073/pnas.88.14.6333	http://dx.doi.org/10.1073/pnas.88.14.6333
DOI	10.1074/jbc.M704138200	http://dx.doi.org/10.1074/jbc.M704138200
DOI	10.1086/500614	http://dx.doi.org/10.1086/500614
DOI	10.1089/dna.1990.9.193	http://dx.doi.org/10.1089/dna.1990.9.193
DOI	10.1093/nar/17.10.3978	http://dx.doi.org/10.1093/nar/17.10.3978
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00250	http://www.drugbank.ca/drugs/DB00250
DrugBank	DB00316	http://www.drugbank.ca/drugs/DB00316
DrugBank	DB00951	http://www.drugbank.ca/drugs/DB00951
DrugBank	DB01015	http://www.drugbank.ca/drugs/DB01015
DrugBank	DB01068	http://www.drugbank.ca/drugs/DB01068
DrugBank	DB04953	http://www.drugbank.ca/drugs/DB04953
EC_number	EC:2.3.1.5	http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.5
EMBL	AC025062	http://www.ebi.ac.uk/ena/data/view/AC025062
EMBL	AC120051	http://www.ebi.ac.uk/ena/data/view/AC120051
EMBL	AF042740	http://www.ebi.ac.uk/ena/data/view/AF042740
EMBL	AF055874	http://www.ebi.ac.uk/ena/data/view/AF055874
EMBL	AF055875	http://www.ebi.ac.uk/ena/data/view/AF055875
EMBL	AF320309	http://www.ebi.ac.uk/ena/data/view/AF320309
EMBL	AF348074	http://www.ebi.ac.uk/ena/data/view/AF348074
EMBL	AF348075	http://www.ebi.ac.uk/ena/data/view/AF348075
EMBL	AY230251	http://www.ebi.ac.uk/ena/data/view/AY230251
EMBL	AY230252	http://www.ebi.ac.uk/ena/data/view/AY230252
EMBL	AY331807	http://www.ebi.ac.uk/ena/data/view/AY331807
EMBL	BC015878	http://www.ebi.ac.uk/ena/data/view/BC015878
EMBL	BC067218	http://www.ebi.ac.uk/ena/data/view/BC067218
EMBL	CR407631	http://www.ebi.ac.uk/ena/data/view/CR407631
EMBL	D10870	http://www.ebi.ac.uk/ena/data/view/D10870
EMBL	D10871	http://www.ebi.ac.uk/ena/data/view/D10871
EMBL	D10872	http://www.ebi.ac.uk/ena/data/view/D10872
EMBL	D90040	http://www.ebi.ac.uk/ena/data/view/D90040
EMBL	D90042	http://www.ebi.ac.uk/ena/data/view/D90042
EMBL	DQ305496	http://www.ebi.ac.uk/ena/data/view/DQ305496
EMBL	DQ305497	http://www.ebi.ac.uk/ena/data/view/DQ305497
EMBL	DQ305498	http://www.ebi.ac.uk/ena/data/view/DQ305498
EMBL	DQ305499	http://www.ebi.ac.uk/ena/data/view/DQ305499
EMBL	DQ305500	http://www.ebi.ac.uk/ena/data/view/DQ305500
EMBL	DQ305501	http://www.ebi.ac.uk/ena/data/view/DQ305501
EMBL	DQ305502	http://www.ebi.ac.uk/ena/data/view/DQ305502
EMBL	DQ305503	http://www.ebi.ac.uk/ena/data/view/DQ305503
EMBL	DQ305504	http://www.ebi.ac.uk/ena/data/view/DQ305504
EMBL	DQ305505	http://www.ebi.ac.uk/ena/data/view/DQ305505
EMBL	DQ305506	http://www.ebi.ac.uk/ena/data/view/DQ305506
EMBL	DQ305507	http://www.ebi.ac.uk/ena/data/view/DQ305507
EMBL	DQ305508	http://www.ebi.ac.uk/ena/data/view/DQ305508
EMBL	DQ305509	http://www.ebi.ac.uk/ena/data/view/DQ305509
EMBL	DQ305510	http://www.ebi.ac.uk/ena/data/view/DQ305510
EMBL	DQ305511	http://www.ebi.ac.uk/ena/data/view/DQ305511
EMBL	DQ305512	http://www.ebi.ac.uk/ena/data/view/DQ305512
EMBL	DQ305513	http://www.ebi.ac.uk/ena/data/view/DQ305513
EMBL	DQ305514	http://www.ebi.ac.uk/ena/data/view/DQ305514
EMBL	DQ305515	http://www.ebi.ac.uk/ena/data/view/DQ305515
EMBL	DQ305516	http://www.ebi.ac.uk/ena/data/view/DQ305516
EMBL	DQ305517	http://www.ebi.ac.uk/ena/data/view/DQ305517
EMBL	DQ305518	http://www.ebi.ac.uk/ena/data/view/DQ305518
EMBL	DQ305519	http://www.ebi.ac.uk/ena/data/view/DQ305519
EMBL	DQ305520	http://www.ebi.ac.uk/ena/data/view/DQ305520
EMBL	DQ305521	http://www.ebi.ac.uk/ena/data/view/DQ305521
EMBL	DQ305522	http://www.ebi.ac.uk/ena/data/view/DQ305522
EMBL	DQ305523	http://www.ebi.ac.uk/ena/data/view/DQ305523
EMBL	DQ305524	http://www.ebi.ac.uk/ena/data/view/DQ305524
EMBL	DQ305525	http://www.ebi.ac.uk/ena/data/view/DQ305525
EMBL	DQ305526	http://www.ebi.ac.uk/ena/data/view/DQ305526
EMBL	DQ305527	http://www.ebi.ac.uk/ena/data/view/DQ305527
EMBL	DQ305528	http://www.ebi.ac.uk/ena/data/view/DQ305528
EMBL	DQ305529	http://www.ebi.ac.uk/ena/data/view/DQ305529
EMBL	DQ305530	http://www.ebi.ac.uk/ena/data/view/DQ305530
EMBL	DQ305531	http://www.ebi.ac.uk/ena/data/view/DQ305531
EMBL	DQ305532	http://www.ebi.ac.uk/ena/data/view/DQ305532
EMBL	DQ305533	http://www.ebi.ac.uk/ena/data/view/DQ305533
EMBL	DQ305534	http://www.ebi.ac.uk/ena/data/view/DQ305534
EMBL	DQ305535	http://www.ebi.ac.uk/ena/data/view/DQ305535
EMBL	DQ305536	http://www.ebi.ac.uk/ena/data/view/DQ305536
EMBL	DQ305537	http://www.ebi.ac.uk/ena/data/view/DQ305537
EMBL	DQ305538	http://www.ebi.ac.uk/ena/data/view/DQ305538
EMBL	DQ305539	http://www.ebi.ac.uk/ena/data/view/DQ305539
EMBL	DQ305540	http://www.ebi.ac.uk/ena/data/view/DQ305540
EMBL	DQ305541	http://www.ebi.ac.uk/ena/data/view/DQ305541
EMBL	DQ305542	http://www.ebi.ac.uk/ena/data/view/DQ305542
EMBL	DQ305543	http://www.ebi.ac.uk/ena/data/view/DQ305543
EMBL	DQ305544	http://www.ebi.ac.uk/ena/data/view/DQ305544
EMBL	DQ305545	http://www.ebi.ac.uk/ena/data/view/DQ305545
EMBL	DQ305546	http://www.ebi.ac.uk/ena/data/view/DQ305546
EMBL	DQ305547	http://www.ebi.ac.uk/ena/data/view/DQ305547
EMBL	DQ305548	http://www.ebi.ac.uk/ena/data/view/DQ305548
EMBL	DQ305549	http://www.ebi.ac.uk/ena/data/view/DQ305549
EMBL	DQ305550	http://www.ebi.ac.uk/ena/data/view/DQ305550
EMBL	DQ305551	http://www.ebi.ac.uk/ena/data/view/DQ305551
EMBL	DQ305552	http://www.ebi.ac.uk/ena/data/view/DQ305552
EMBL	DQ305553	http://www.ebi.ac.uk/ena/data/view/DQ305553
EMBL	DQ305554	http://www.ebi.ac.uk/ena/data/view/DQ305554
EMBL	DQ305555	http://www.ebi.ac.uk/ena/data/view/DQ305555
EMBL	DQ305556	http://www.ebi.ac.uk/ena/data/view/DQ305556
EMBL	DQ305557	http://www.ebi.ac.uk/ena/data/view/DQ305557
EMBL	DQ305558	http://www.ebi.ac.uk/ena/data/view/DQ305558
EMBL	DQ305559	http://www.ebi.ac.uk/ena/data/view/DQ305559
EMBL	DQ305560	http://www.ebi.ac.uk/ena/data/view/DQ305560
EMBL	DQ305561	http://www.ebi.ac.uk/ena/data/view/DQ305561
EMBL	DQ305562	http://www.ebi.ac.uk/ena/data/view/DQ305562
EMBL	DQ305563	http://www.ebi.ac.uk/ena/data/view/DQ305563
EMBL	DQ305564	http://www.ebi.ac.uk/ena/data/view/DQ305564
EMBL	DQ305565	http://www.ebi.ac.uk/ena/data/view/DQ305565
EMBL	DQ305566	http://www.ebi.ac.uk/ena/data/view/DQ305566
EMBL	DQ305567	http://www.ebi.ac.uk/ena/data/view/DQ305567
EMBL	DQ305568	http://www.ebi.ac.uk/ena/data/view/DQ305568
EMBL	DQ305569	http://www.ebi.ac.uk/ena/data/view/DQ305569
EMBL	DQ305570	http://www.ebi.ac.uk/ena/data/view/DQ305570
EMBL	DQ305571	http://www.ebi.ac.uk/ena/data/view/DQ305571
EMBL	DQ305572	http://www.ebi.ac.uk/ena/data/view/DQ305572
EMBL	DQ305573	http://www.ebi.ac.uk/ena/data/view/DQ305573
EMBL	DQ305574	http://www.ebi.ac.uk/ena/data/view/DQ305574
EMBL	DQ305575	http://www.ebi.ac.uk/ena/data/view/DQ305575
EMBL	DQ305576	http://www.ebi.ac.uk/ena/data/view/DQ305576
EMBL	DQ305577	http://www.ebi.ac.uk/ena/data/view/DQ305577
EMBL	DQ305578	http://www.ebi.ac.uk/ena/data/view/DQ305578
EMBL	DQ305579	http://www.ebi.ac.uk/ena/data/view/DQ305579
EMBL	DQ305580	http://www.ebi.ac.uk/ena/data/view/DQ305580
EMBL	DQ305581	http://www.ebi.ac.uk/ena/data/view/DQ305581
EMBL	DQ305582	http://www.ebi.ac.uk/ena/data/view/DQ305582
EMBL	DQ305583	http://www.ebi.ac.uk/ena/data/view/DQ305583
EMBL	DQ305584	http://www.ebi.ac.uk/ena/data/view/DQ305584
EMBL	DQ305585	http://www.ebi.ac.uk/ena/data/view/DQ305585
EMBL	DQ305586	http://www.ebi.ac.uk/ena/data/view/DQ305586
EMBL	DQ305587	http://www.ebi.ac.uk/ena/data/view/DQ305587
EMBL	DQ305588	http://www.ebi.ac.uk/ena/data/view/DQ305588
EMBL	DQ305589	http://www.ebi.ac.uk/ena/data/view/DQ305589
EMBL	DQ305590	http://www.ebi.ac.uk/ena/data/view/DQ305590
EMBL	DQ305591	http://www.ebi.ac.uk/ena/data/view/DQ305591
EMBL	DQ305592	http://www.ebi.ac.uk/ena/data/view/DQ305592
EMBL	DQ305593	http://www.ebi.ac.uk/ena/data/view/DQ305593
EMBL	DQ305594	http://www.ebi.ac.uk/ena/data/view/DQ305594
EMBL	DQ305595	http://www.ebi.ac.uk/ena/data/view/DQ305595
EMBL	DQ305596	http://www.ebi.ac.uk/ena/data/view/DQ305596
EMBL	DQ305597	http://www.ebi.ac.uk/ena/data/view/DQ305597
EMBL	DQ305598	http://www.ebi.ac.uk/ena/data/view/DQ305598
EMBL	DQ305599	http://www.ebi.ac.uk/ena/data/view/DQ305599
EMBL	DQ305600	http://www.ebi.ac.uk/ena/data/view/DQ305600
EMBL	DQ305601	http://www.ebi.ac.uk/ena/data/view/DQ305601
EMBL	DQ305602	http://www.ebi.ac.uk/ena/data/view/DQ305602
EMBL	DQ305603	http://www.ebi.ac.uk/ena/data/view/DQ305603
EMBL	DQ305604	http://www.ebi.ac.uk/ena/data/view/DQ305604
EMBL	DQ305605	http://www.ebi.ac.uk/ena/data/view/DQ305605
EMBL	DQ305606	http://www.ebi.ac.uk/ena/data/view/DQ305606
EMBL	DQ305607	http://www.ebi.ac.uk/ena/data/view/DQ305607
EMBL	DQ305608	http://www.ebi.ac.uk/ena/data/view/DQ305608
EMBL	DQ305609	http://www.ebi.ac.uk/ena/data/view/DQ305609
EMBL	DQ305610	http://www.ebi.ac.uk/ena/data/view/DQ305610
EMBL	DQ305611	http://www.ebi.ac.uk/ena/data/view/DQ305611
EMBL	DQ305612	http://www.ebi.ac.uk/ena/data/view/DQ305612
EMBL	DQ305613	http://www.ebi.ac.uk/ena/data/view/DQ305613
EMBL	DQ305614	http://www.ebi.ac.uk/ena/data/view/DQ305614
EMBL	DQ305615	http://www.ebi.ac.uk/ena/data/view/DQ305615
EMBL	DQ305616	http://www.ebi.ac.uk/ena/data/view/DQ305616
EMBL	DQ305617	http://www.ebi.ac.uk/ena/data/view/DQ305617
EMBL	DQ305618	http://www.ebi.ac.uk/ena/data/view/DQ305618
EMBL	DQ305619	http://www.ebi.ac.uk/ena/data/view/DQ305619
EMBL	DQ305620	http://www.ebi.ac.uk/ena/data/view/DQ305620
EMBL	DQ305621	http://www.ebi.ac.uk/ena/data/view/DQ305621
EMBL	DQ305622	http://www.ebi.ac.uk/ena/data/view/DQ305622
EMBL	DQ305623	http://www.ebi.ac.uk/ena/data/view/DQ305623
EMBL	DQ305624	http://www.ebi.ac.uk/ena/data/view/DQ305624
EMBL	DQ305625	http://www.ebi.ac.uk/ena/data/view/DQ305625
EMBL	DQ305626	http://www.ebi.ac.uk/ena/data/view/DQ305626
EMBL	DQ305627	http://www.ebi.ac.uk/ena/data/view/DQ305627
EMBL	DQ305628	http://www.ebi.ac.uk/ena/data/view/DQ305628
EMBL	DQ305629	http://www.ebi.ac.uk/ena/data/view/DQ305629
EMBL	DQ305630	http://www.ebi.ac.uk/ena/data/view/DQ305630
EMBL	DQ305631	http://www.ebi.ac.uk/ena/data/view/DQ305631
EMBL	DQ305632	http://www.ebi.ac.uk/ena/data/view/DQ305632
EMBL	DQ305633	http://www.ebi.ac.uk/ena/data/view/DQ305633
EMBL	DQ305634	http://www.ebi.ac.uk/ena/data/view/DQ305634
EMBL	DQ305635	http://www.ebi.ac.uk/ena/data/view/DQ305635
EMBL	DQ305636	http://www.ebi.ac.uk/ena/data/view/DQ305636
EMBL	DQ305637	http://www.ebi.ac.uk/ena/data/view/DQ305637
EMBL	DQ305638	http://www.ebi.ac.uk/ena/data/view/DQ305638
EMBL	DQ305639	http://www.ebi.ac.uk/ena/data/view/DQ305639
EMBL	DQ305640	http://www.ebi.ac.uk/ena/data/view/DQ305640
EMBL	DQ305641	http://www.ebi.ac.uk/ena/data/view/DQ305641
EMBL	DQ305642	http://www.ebi.ac.uk/ena/data/view/DQ305642
EMBL	DQ305643	http://www.ebi.ac.uk/ena/data/view/DQ305643
EMBL	DQ305644	http://www.ebi.ac.uk/ena/data/view/DQ305644
EMBL	DQ305645	http://www.ebi.ac.uk/ena/data/view/DQ305645
EMBL	DQ305646	http://www.ebi.ac.uk/ena/data/view/DQ305646
EMBL	DQ305647	http://www.ebi.ac.uk/ena/data/view/DQ305647
EMBL	DQ305648	http://www.ebi.ac.uk/ena/data/view/DQ305648
EMBL	DQ305649	http://www.ebi.ac.uk/ena/data/view/DQ305649
EMBL	DQ305650	http://www.ebi.ac.uk/ena/data/view/DQ305650
EMBL	DQ305651	http://www.ebi.ac.uk/ena/data/view/DQ305651
EMBL	DQ305652	http://www.ebi.ac.uk/ena/data/view/DQ305652
EMBL	DQ305653	http://www.ebi.ac.uk/ena/data/view/DQ305653
EMBL	DQ305654	http://www.ebi.ac.uk/ena/data/view/DQ305654
EMBL	DQ305655	http://www.ebi.ac.uk/ena/data/view/DQ305655
EMBL	M75163	http://www.ebi.ac.uk/ena/data/view/M75163
EMBL	U23052	http://www.ebi.ac.uk/ena/data/view/U23052
EMBL	U23434	http://www.ebi.ac.uk/ena/data/view/U23434
EMBL	U53473	http://www.ebi.ac.uk/ena/data/view/U53473
EMBL	X14672	http://www.ebi.ac.uk/ena/data/view/X14672
ENZYME	2.3.1.5	http://enzyme.expasy.org/EC/2.3.1.5
Ensembl	ENST00000286479	http://www.ensembl.org/id/ENST00000286479
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_function	GO:0004060	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004060
GO_function	GO:0015179	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015179
GO_process	GO:0006805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006805
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0016746	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	NAT2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=NAT2
GeneID	10	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10
HGNC	HGNC:7646	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:7646
HOVERGEN	HBG000165	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000165&db=HOVERGEN
HPA	HPA043704	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA043704
InParanoid	P11245	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P11245
IntAct	P11245	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P11245*
IntEnz	2.3.1.5	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.5
InterPro	IPR001447	http://www.ebi.ac.uk/interpro/entry/IPR001447
Jabion	10	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:10	http://www.genome.jp/dbget-bin/www_bget?hsa:10
KEGG_Orthology	KO:K00622	http://www.genome.jp/dbget-bin/www_bget?KO:K00622
KEGG_Pathway	ko00232	http://www.genome.jp/kegg-bin/show_pathway?ko00232
KEGG_Pathway	ko00633	http://www.genome.jp/kegg-bin/show_pathway?ko00633
KEGG_Pathway	ko00983	http://www.genome.jp/kegg-bin/show_pathway?ko00983
KEGG_Pathway	ko05204	http://www.genome.jp/kegg-bin/show_pathway?ko05204
KEGG_Reaction	rn:R07940	http://www.genome.jp/dbget-bin/www_bget?rn:R07940
KEGG_Reaction	rn:R08036	http://www.genome.jp/dbget-bin/www_bget?rn:R08036
KEGG_Reaction	rn:R08248	http://www.genome.jp/dbget-bin/www_bget?rn:R08248
KEGG_Reaction	rn:R08250	http://www.genome.jp/dbget-bin/www_bget?rn:R08250
MIM	243400	http://www.ncbi.nlm.nih.gov/omim/243400
MIM	612182	http://www.ncbi.nlm.nih.gov/omim/612182
Orphanet	240887	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=240887
OrthoDB	EOG091G0CO6	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0CO6
PANTHER	PTHR11786	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11786
PDB	2PFR	http://www.ebi.ac.uk/pdbe-srv/view/entry/2PFR
PDBsum	2PFR	http://www.ebi.ac.uk/pdbsum/2PFR
PRINTS	PR01543	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01543
PSORT	swissprot:ARY2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ARY2_HUMAN
PSORT-B	swissprot:ARY2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ARY2_HUMAN
PSORT2	swissprot:ARY2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ARY2_HUMAN
Pfam	PF00797	http://pfam.xfam.org/family/PF00797
PharmGKB	PA18	http://www.pharmgkb.org/do/serve?objId=PA18&objCls=Gene
Phobius	swissprot:ARY2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ARY2_HUMAN
PhylomeDB	P11245	http://phylomedb.org/?seqid=P11245
ProteinModelPortal	P11245	http://www.proteinmodelportal.org/query/uniprot/P11245
PubMed	1381364	http://www.ncbi.nlm.nih.gov/pubmed/1381364
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16416399	http://www.ncbi.nlm.nih.gov/pubmed/16416399
PubMed	16421571	http://www.ncbi.nlm.nih.gov/pubmed/16421571
PubMed	1676262	http://www.ncbi.nlm.nih.gov/pubmed/1676262
PubMed	17656365	http://www.ncbi.nlm.nih.gov/pubmed/17656365
PubMed	1968463	http://www.ncbi.nlm.nih.gov/pubmed/1968463
PubMed	2068113	http://www.ncbi.nlm.nih.gov/pubmed/2068113
PubMed	2340091	http://www.ncbi.nlm.nih.gov/pubmed/2340091
PubMed	2734109	http://www.ncbi.nlm.nih.gov/pubmed/2734109
PubMed	2924904	http://www.ncbi.nlm.nih.gov/pubmed/2924904
PubMed	7915226	http://www.ncbi.nlm.nih.gov/pubmed/7915226
PubMed	7920692	http://www.ncbi.nlm.nih.gov/pubmed/7920692
PubMed	8466518	http://www.ncbi.nlm.nih.gov/pubmed/8466518
Reactome	R-HSA-156582	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-156582
RefSeq	NP_000006	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000006
RefSeq	XP_016868427	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016868427
SMR	P11245	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P11245
STRING	9606.ENSP00000286479	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000286479&targetmode=cogs
STRING	COG2162	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2162&targetmode=cogs
UCSC	uc003wyw	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003wyw&org=rat
UniGene	Hs	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs
UniProtKB	ARY2_HUMAN	http://www.uniprot.org/uniprot/ARY2_HUMAN
UniProtKB-AC	P11245	http://www.uniprot.org/uniprot/P11245
charge	swissprot:ARY2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ARY2_HUMAN
eggNOG	COG2162	http://eggnogapi.embl.de/nog_data/html/tree/COG2162
eggNOG	ENOG410IFD6	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IFD6
epestfind	swissprot:ARY2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ARY2_HUMAN
garnier	swissprot:ARY2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ARY2_HUMAN
helixturnhelix	swissprot:ARY2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARY2_HUMAN
hmoment	swissprot:ARY2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ARY2_HUMAN
iep	swissprot:ARY2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ARY2_HUMAN
inforesidue	swissprot:ARY2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ARY2_HUMAN
neXtProt	NX_P11245	http://www.nextprot.org/db/entry/NX_P11245
octanol	swissprot:ARY2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ARY2_HUMAN
pepcoil	swissprot:ARY2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ARY2_HUMAN
pepdigest	swissprot:ARY2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ARY2_HUMAN
pepinfo	swissprot:ARY2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ARY2_HUMAN
pepnet	swissprot:ARY2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ARY2_HUMAN
pepstats	swissprot:ARY2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ARY2_HUMAN
pepwheel	swissprot:ARY2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ARY2_HUMAN
pepwindow	swissprot:ARY2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ARY2_HUMAN
sigcleave	swissprot:ARY2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ARY2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AP1S3_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q96PC3-1; Sequence=Displayed; Name=2; IsoId=Q96PC3-2; Sequence=VSP_015944; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=4; IsoId=Q96PC3-4; Sequence=VSP_040384; Note=No experimental confirmation available.; Name=3; IsoId=Q96PC3-3; Sequence=VSP_015942, VSP_015943; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 
# AltName	AP1S3_HUMAN	Adaptor protein complex AP-1 subunit sigma-1C
# AltName	AP1S3_HUMAN	Adaptor-related protein complex 1 subunit sigma-1C
# AltName	AP1S3_HUMAN	Clathrin assembly protein complex 1 sigma-1C small chain
# AltName	AP1S3_HUMAN	Golgi adaptor HA1/AP1 adaptin sigma-1C subunit
# AltName	AP1S3_HUMAN	Sigma 1C subunit of AP-1 clathrin
# AltName	AP1S3_HUMAN	Sigma-adaptin 1C
# AltName	AP1S3_HUMAN	Sigma1C-adaptin
# BioGrid	126229	4
# CCDS	CCDS42827	-. [Q96PC3-4]
# ChiTaRS	AP1S3	human
# DISEASE	AP1S3_HUMAN	Psoriasis 15, pustular (PSORS15) [MIM 616106]  A form of pustular psoriasis, a life-threatening disease defined by repeated flares of sudden onset consisting of diffuse erythematous skin eruption characterized by rapid coverage with pustules, high-grade fever, asthenia, marked leukocytosis, and elevated serum levels of C-reactive protein. {ECO 0000269|PubMed 24791904}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# Ensembl	ENST00000396654	ENSP00000379891; ENSG00000152056. [Q96PC3-4]
# Ensembl	ENST00000415298	ENSP00000401705; ENSG00000152056. [Q96PC3-3]
# Ensembl	ENST00000443700	ENSP00000397155; ENSG00000152056. [Q96PC3-2]
# Ensembl	ENST00000446015	ENSP00000388738; ENSG00000152056. [Q96PC3-1]
# ExpressionAtlas	Q96PC3	baseline and differential
# FUNCTION	AP1S3_HUMAN	Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Involved in TLR3 trafficking (PubMed 24791904). {ECO 0000269|PubMed 24791904}. 
# GO_component	GO:0000139	Golgi membrane; TAS:Reactome.
# GO_component	GO:0005765	lysosomal membrane; TAS:Reactome.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0005905	clathrin-coated pit; IEA:UniProtKB-SubCell.
# GO_component	GO:0030117	membrane coat; IEA:InterPro.
# GO_component	GO:0030659	cytoplasmic vesicle membrane; TAS:Reactome.
# GO_component	GO:0030669	clathrin-coated endocytic vesicle membrane; TAS:Reactome.
# GO_component	GO:0032588	trans-Golgi network membrane; TAS:Reactome.
# GO_function	GO:0008565	protein transporter activity; IEA:InterPro.
# GO_process	GO:0006605	protein targeting; IMP:UniProtKB.
# GO_process	GO:0016192	vesicle-mediated transport; IEA:InterPro.
# GO_process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
# GO_process	GO:0050690	regulation of defense response to virus by virus; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006605	protein targeting
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# Genevisible	Q96PC3	HS
# HGNC	HGNC:18971	AP1S3
# INTERACTION	AP1S3_HUMAN	Q6PD74 AAGAB; NbExp=3; IntAct=EBI-3923129, EBI-719906; 
# IntAct	Q96PC3	5
# InterPro	IPR000804	Clathrin_sm-chain_CS
# InterPro	IPR011012	Longin-like_dom
# InterPro	IPR016635	AP_complex_ssu
# InterPro	IPR022775	AP_mu_sigma_su
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Pathway	ko04142	Lysosome
# MIM	615781	gene
# MIM	616106	phenotype
# Organism	AP1S3_HUMAN	Homo sapiens (Human)
# Orphanet	163927	Pustulosis palmaris et plantaris
# Orphanet	163931	Acrodermatitis continua suppurativa of Hallopeau
# Orphanet	247353	Generalized pustular psoriasis
# PANTHER	PTHR11753	PTHR11753
# PDB	4HMY	X-ray; 7.00 A; S=1-154
# PIRSF	PIRSF015588	AP_complex_sigma
# PROSITE	PS00989	CLAT_ADAPTOR_S
# Pfam	PF01217	Clat_adaptor_s
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-164940	Nef mediated downregulation of MHC class I complex cell surface expression
# Reactome	R-HSA-2132295	MHC class II antigen presentation
# Reactome	R-HSA-432720	Lysosome Vesicle Biogenesis
# Reactome	R-HSA-432722	Golgi Associated Vesicle Biogenesis
# RecName	AP1S3_HUMAN	AP-1 complex subunit sigma-3
# RefSeq	NP_001034658	NM_001039569.1. [Q96PC3-4]
# SIMILARITY	Belongs to the adaptor complexes small subunit family. {ECO	0000305}.
# SUBCELLULAR LOCATION	AP1S3_HUMAN	Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. 
# SUBUNIT	AP1S3_HUMAN	Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta- type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). 
# SUPFAM	SSF64356	SSF64356
# TISSUE SPECIFICITY	AP1S3_HUMAN	Widely expressed. 
# UCSC	uc002vnn	human. [Q96PC3-1]
# eggNOG	COG5030	LUCA
# eggNOG	KOG0934	Eukaryota
BLAST	swissprot:AP1S3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AP1S3_HUMAN
BioCyc	ZFISH:ENSG00000152056-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000152056-MONOMER
COXPRESdb	130340	http://coxpresdb.jp/data/gene/130340.shtml
CleanEx	HS_AP1S3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AP1S3
DOI	10.1016/j.ajhg.2014.04.005	http://dx.doi.org/10.1016/j.ajhg.2014.04.005
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1091/mbc.12.10.2907	http://dx.doi.org/10.1091/mbc.12.10.2907
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC012512	http://www.ebi.ac.uk/ena/data/view/AC012512
EMBL	AC093884	http://www.ebi.ac.uk/ena/data/view/AC093884
EMBL	AF393369	http://www.ebi.ac.uk/ena/data/view/AF393369
EMBL	AK299026	http://www.ebi.ac.uk/ena/data/view/AK299026
EMBL	BC009606	http://www.ebi.ac.uk/ena/data/view/BC009606
EMBL	BC021898	http://www.ebi.ac.uk/ena/data/view/BC021898
Ensembl	ENST00000396654	http://www.ensembl.org/id/ENST00000396654
Ensembl	ENST00000415298	http://www.ensembl.org/id/ENST00000415298
Ensembl	ENST00000443700	http://www.ensembl.org/id/ENST00000443700
Ensembl	ENST00000446015	http://www.ensembl.org/id/ENST00000446015
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005905	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005905
GO_component	GO:0030117	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030117
GO_component	GO:0030659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030659
GO_component	GO:0030669	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030669
GO_component	GO:0032588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032588
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0006605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605
GO_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GO_process	GO:0019886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019886
GO_process	GO:0050690	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050690
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GeneCards	AP1S3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=AP1S3
GeneID	130340	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=130340
GeneTree	ENSGT00530000062839	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062839
HGNC	HGNC:18971	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18971
HOGENOM	HOG000185227	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000185227&db=HOGENOM6
HOVERGEN	HBG050517	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050517&db=HOVERGEN
HPA	HPA066782	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA066782
InParanoid	Q96PC3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96PC3
IntAct	Q96PC3	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96PC3*
InterPro	IPR000804	http://www.ebi.ac.uk/interpro/entry/IPR000804
InterPro	IPR011012	http://www.ebi.ac.uk/interpro/entry/IPR011012
InterPro	IPR016635	http://www.ebi.ac.uk/interpro/entry/IPR016635
InterPro	IPR022775	http://www.ebi.ac.uk/interpro/entry/IPR022775
Jabion	130340	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=130340
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Gene	hsa:130340	http://www.genome.jp/dbget-bin/www_bget?hsa:130340
KEGG_Orthology	KO:K12395	http://www.genome.jp/dbget-bin/www_bget?KO:K12395
KEGG_Pathway	ko04142	http://www.genome.jp/kegg-bin/show_pathway?ko04142
MIM	615781	http://www.ncbi.nlm.nih.gov/omim/615781
MIM	616106	http://www.ncbi.nlm.nih.gov/omim/616106
OMA	ESDMLQE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ESDMLQE
Orphanet	163927	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=163927
Orphanet	163931	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=163931
Orphanet	247353	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=247353
OrthoDB	EOG091G0QZV	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0QZV
PANTHER	PTHR11753	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11753
PDB	4HMY	http://www.ebi.ac.uk/pdbe-srv/view/entry/4HMY
PDBsum	4HMY	http://www.ebi.ac.uk/pdbsum/4HMY
PROSITE	PS00989	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00989
PSORT	swissprot:AP1S3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AP1S3_HUMAN
PSORT-B	swissprot:AP1S3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AP1S3_HUMAN
PSORT2	swissprot:AP1S3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AP1S3_HUMAN
Pfam	PF01217	http://pfam.xfam.org/family/PF01217
Phobius	swissprot:AP1S3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AP1S3_HUMAN
PhylomeDB	Q96PC3	http://phylomedb.org/?seqid=Q96PC3
ProteinModelPortal	Q96PC3	http://www.proteinmodelportal.org/query/uniprot/Q96PC3
PubMed	11598180	http://www.ncbi.nlm.nih.gov/pubmed/11598180
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	24791904	http://www.ncbi.nlm.nih.gov/pubmed/24791904
Reactome	R-HSA-164940	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-164940
Reactome	R-HSA-2132295	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2132295
Reactome	R-HSA-432720	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432720
Reactome	R-HSA-432722	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432722
RefSeq	NP_001034658	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001034658
SMR	Q96PC3	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q96PC3
STRING	9606.ENSP00000379891	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000379891&targetmode=cogs
SUPFAM	SSF64356	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF64356
UCSC	uc002vnn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002vnn&org=rat
UniGene	Hs.632555	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.632555
UniProtKB	AP1S3_HUMAN	http://www.uniprot.org/uniprot/AP1S3_HUMAN
UniProtKB-AC	Q96PC3	http://www.uniprot.org/uniprot/Q96PC3
charge	swissprot:AP1S3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AP1S3_HUMAN
eggNOG	COG5030	http://eggnogapi.embl.de/nog_data/html/tree/COG5030
eggNOG	KOG0934	http://eggnogapi.embl.de/nog_data/html/tree/KOG0934
epestfind	swissprot:AP1S3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AP1S3_HUMAN
garnier	swissprot:AP1S3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AP1S3_HUMAN
helixturnhelix	swissprot:AP1S3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AP1S3_HUMAN
hmoment	swissprot:AP1S3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AP1S3_HUMAN
iep	swissprot:AP1S3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AP1S3_HUMAN
inforesidue	swissprot:AP1S3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AP1S3_HUMAN
neXtProt	NX_Q96PC3	http://www.nextprot.org/db/entry/NX_Q96PC3
octanol	swissprot:AP1S3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AP1S3_HUMAN
pepcoil	swissprot:AP1S3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AP1S3_HUMAN
pepdigest	swissprot:AP1S3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AP1S3_HUMAN
pepinfo	swissprot:AP1S3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AP1S3_HUMAN
pepnet	swissprot:AP1S3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AP1S3_HUMAN
pepstats	swissprot:AP1S3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AP1S3_HUMAN
pepwheel	swissprot:AP1S3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AP1S3_HUMAN
pepwindow	swissprot:AP1S3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AP1S3_HUMAN
sigcleave	swissprot:AP1S3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AP1S3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GBRB2_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Long, Beta-2L; IsoId=P47870-2; Sequence=Displayed; Name=2; Synonyms=Short, Beta-2S; IsoId=P47870-1; Sequence=VSP_038825; Name=3; Synonyms=Beta-2S1; IsoId=P47870-3; Sequence=VSP_038823, VSP_038824, VSP_038828; Name=4; Synonyms=Beta-2S2; IsoId=P47870-4; Sequence=VSP_038825, VSP_038826, VSP_038827; 
# AltName	GBRB2_HUMAN	GABA(A) receptor subunit beta-2
# BioGrid	108835	4
# CCDS	CCDS4354	-. [P47870-1]
# CCDS	CCDS4355	-. [P47870-2]
# DrugBank	DB00186	Lorazepam
# DrugBank	DB00189	Ethchlorvynol
# DrugBank	DB00228	Enflurane
# DrugBank	DB00231	Temazepam
# DrugBank	DB00237	Butabarbital
# DrugBank	DB00241	Butalbital
# DrugBank	DB00273	Topiramate
# DrugBank	DB00292	Etomidate
# DrugBank	DB00306	Talbutal
# DrugBank	DB00312	Pentobarbital
# DrugBank	DB00334	Olanzapine
# DrugBank	DB00349	Clobazam
# DrugBank	DB00371	Meprobamate
# DrugBank	DB00402	Eszopiclone
# DrugBank	DB00404	Alprazolam
# DrugBank	DB00475	Chlordiazepoxide
# DrugBank	DB00543	Amoxapine
# DrugBank	DB00546	Adinazolam
# DrugBank	DB00628	Clorazepate
# DrugBank	DB00659	Acamprosate
# DrugBank	DB00683	Midazolam
# DrugBank	DB00690	Flurazepam
# DrugBank	DB00753	Isoflurane
# DrugBank	DB00794	Primidone
# DrugBank	DB00801	Halazepam
# DrugBank	DB00818	Propofol
# DrugBank	DB00829	Diazepam
# DrugBank	DB00842	Oxazepam
# DrugBank	DB00897	Triazolam
# DrugBank	DB00898	Ethanol
# DrugBank	DB01028	Methoxyflurane
# DrugBank	DB01049	Ergoloid mesylate
# DrugBank	DB01068	Clonazepam
# DrugBank	DB01107	Methyprylon
# DrugBank	DB01159	Halothane
# DrugBank	DB01189	Desflurane
# DrugBank	DB01205	Flumazenil
# DrugBank	DB01215	Estazolam
# DrugBank	DB01236	Sevoflurane
# DrugBank	DB01381	Ginkgo biloba
# DrugBank	DB01437	Glutethimide
# DrugBank	DB01558	Bromazepam
# DrugBank	DB01559	Clotiazepam
# DrugBank	DB01567	Fludiazepam
# DrugBank	DB01588	Prazepam
# DrugBank	DB01589	Quazepam
# DrugBank	DB01594	Cinolazepam
# DrugBank	DB01595	Nitrazepam
# DrugBank	DB06716	Fospropofol
# Ensembl	ENST00000274547	ENSP00000274547; ENSG00000145864. [P47870-2]
# Ensembl	ENST00000353437	ENSP00000274546; ENSG00000145864. [P47870-1]
# Ensembl	ENST00000393959	ENSP00000377531; ENSG00000145864. [P47870-2]
# Ensembl	ENST00000520240	ENSP00000429320; ENSG00000145864. [P47870-1]
# Ensembl	ENST00000612710	ENSP00000480066; ENSG00000145864. [P47870-3]
# ExpressionAtlas	P47870	baseline and differential
# FUNCTION	GBRB2_HUMAN	Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel. {ECO 0000269|PubMed 19763268, ECO 0000269|PubMed 8264558}. 
# GO_component	GO:0005829	cytosol; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; ISS:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_component	GO:1902711	GABA-A receptor complex; ISS:UniProtKB.
# GO_function	GO:0004890	GABA-A receptor activity; ISS:BHF-UCL.
# GO_function	GO:0005237	inhibitory extracellular ligand-gated ion channel activity; IEA:Ensembl.
# GO_function	GO:0005254	chloride channel activity; ISS:UniProtKB.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007214	gamma-aminobutyric acid signaling pathway; TAS:ProtInc.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:ProtInc.
# GO_process	GO:0007605	sensory perception of sound; IEA:Ensembl.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0043524	negative regulation of neuron apoptotic process; IEA:Ensembl.
# GO_process	GO:0051932	synaptic transmission, GABAergic; ISS:BHF-UCL.
# GO_process	GO:0060119	inner ear receptor cell development; IEA:Ensembl.
# GO_process	GO:0060384	innervation; IEA:Ensembl.
# GO_process	GO:0071420	cellular response to histamine; ISS:UniProtKB.
# GO_process	GO:0090102	cochlea development; IEA:Ensembl.
# GO_process	GO:1902476	chloride transmembrane transport; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.70.170.10	-; 1.
# Genevisible	P47870	HS
# HGNC	HGNC:4082	GABRB2
# InterPro	IPR002289	GABAAb_rcpt
# InterPro	IPR006028	GABAA/Glycine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04726	Serotonergic synapse
# KEGG_Pathway	ko04727	GABAergic synapse
# KEGG_Pathway	ko05032	Morphine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# MIM	600232	gene
# Organism	GBRB2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR18945	PTHR18945; 2
# PIR	I52656	I52656
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00253	GABAARECEPTR
# PRINTS	PR01160	GABAARBETA
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-112314	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
# Reactome	R-HSA-975298	Ligand-gated ion channel transport
# Reactome	R-HSA-977441	GABA A receptor activation
# RecName	GBRB2_HUMAN	Gamma-aminobutyric acid receptor subunit beta-2
# RefSeq	NP_000804	NM_000813.2. [P47870-1]
# RefSeq	NP_068711	NM_021911.2. [P47870-2]
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB2 sub-subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	GBRB2_HUMAN	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane {ECO 0000269|PubMed 19763268, ECO 0000269|PubMed 8264558}; Multi- pass membrane protein {ECO 0000255}. Cytoplasmic vesicle membrane {ECO 0000250|UniProtKB P63138}. 
# SUBUNIT	GBRB2_HUMAN	Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains (PubMed 8264558). Interacts with UBQLN1 (By similarity). Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents (By similarity). May interact with KIF21B (By similarity). {ECO 0000250|UniProtKB P63138, ECO 0000269|PubMed 8264558}. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112; 2
# TCDB	1.A.9.5	the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family
# TIGRFAMs	TIGR00860	LIC
# TISSUE SPECIFICITY	GBRB2_HUMAN	Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression. {ECO 0000269|PubMed 16983389, ECO 0000269|PubMed 19763268}. 
# UCSC	uc003lyr	human. [P47870-2]
# WEB RESOURCE	GBRB2_HUMAN	Name=Protein Spotlight; Note=Forbidden fruit - Issue 56 of March 2005; URL="http //web.expasy.org/spotlight/back_issues/056";
# eggNOG	ENOG410XPWH	LUCA
# eggNOG	KOG3643	Eukaryota
BLAST	swissprot:GBRB2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GBRB2_HUMAN
COXPRESdb	2561	http://coxpresdb.jp/data/gene/2561.shtml
CleanEx	HS_GABRB2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GABRB2
DOI	10.1016/0169-328X(94)00228-7	http://dx.doi.org/10.1016/0169-328X(94)00228-7
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.mp.4001899	http://dx.doi.org/10.1038/sj.mp.4001899
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1371/journal.pone.0006977	http://dx.doi.org/10.1371/journal.pone.0006977
DrugBank	DB00186	http://www.drugbank.ca/drugs/DB00186
DrugBank	DB00189	http://www.drugbank.ca/drugs/DB00189
DrugBank	DB00228	http://www.drugbank.ca/drugs/DB00228
DrugBank	DB00231	http://www.drugbank.ca/drugs/DB00231
DrugBank	DB00237	http://www.drugbank.ca/drugs/DB00237
DrugBank	DB00241	http://www.drugbank.ca/drugs/DB00241
DrugBank	DB00273	http://www.drugbank.ca/drugs/DB00273
DrugBank	DB00292	http://www.drugbank.ca/drugs/DB00292
DrugBank	DB00306	http://www.drugbank.ca/drugs/DB00306
DrugBank	DB00312	http://www.drugbank.ca/drugs/DB00312
DrugBank	DB00334	http://www.drugbank.ca/drugs/DB00334
DrugBank	DB00349	http://www.drugbank.ca/drugs/DB00349
DrugBank	DB00371	http://www.drugbank.ca/drugs/DB00371
DrugBank	DB00402	http://www.drugbank.ca/drugs/DB00402
DrugBank	DB00404	http://www.drugbank.ca/drugs/DB00404
DrugBank	DB00475	http://www.drugbank.ca/drugs/DB00475
DrugBank	DB00543	http://www.drugbank.ca/drugs/DB00543
DrugBank	DB00546	http://www.drugbank.ca/drugs/DB00546
DrugBank	DB00628	http://www.drugbank.ca/drugs/DB00628
DrugBank	DB00659	http://www.drugbank.ca/drugs/DB00659
DrugBank	DB00683	http://www.drugbank.ca/drugs/DB00683
DrugBank	DB00690	http://www.drugbank.ca/drugs/DB00690
DrugBank	DB00753	http://www.drugbank.ca/drugs/DB00753
DrugBank	DB00794	http://www.drugbank.ca/drugs/DB00794
DrugBank	DB00801	http://www.drugbank.ca/drugs/DB00801
DrugBank	DB00818	http://www.drugbank.ca/drugs/DB00818
DrugBank	DB00829	http://www.drugbank.ca/drugs/DB00829
DrugBank	DB00842	http://www.drugbank.ca/drugs/DB00842
DrugBank	DB00897	http://www.drugbank.ca/drugs/DB00897
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01028	http://www.drugbank.ca/drugs/DB01028
DrugBank	DB01049	http://www.drugbank.ca/drugs/DB01049
DrugBank	DB01068	http://www.drugbank.ca/drugs/DB01068
DrugBank	DB01107	http://www.drugbank.ca/drugs/DB01107
DrugBank	DB01159	http://www.drugbank.ca/drugs/DB01159
DrugBank	DB01189	http://www.drugbank.ca/drugs/DB01189
DrugBank	DB01205	http://www.drugbank.ca/drugs/DB01205
DrugBank	DB01215	http://www.drugbank.ca/drugs/DB01215
DrugBank	DB01236	http://www.drugbank.ca/drugs/DB01236
DrugBank	DB01381	http://www.drugbank.ca/drugs/DB01381
DrugBank	DB01437	http://www.drugbank.ca/drugs/DB01437
DrugBank	DB01558	http://www.drugbank.ca/drugs/DB01558
DrugBank	DB01559	http://www.drugbank.ca/drugs/DB01559
DrugBank	DB01567	http://www.drugbank.ca/drugs/DB01567
DrugBank	DB01588	http://www.drugbank.ca/drugs/DB01588
DrugBank	DB01589	http://www.drugbank.ca/drugs/DB01589
DrugBank	DB01594	http://www.drugbank.ca/drugs/DB01594
DrugBank	DB01595	http://www.drugbank.ca/drugs/DB01595
DrugBank	DB06716	http://www.drugbank.ca/drugs/DB06716
EMBL	AK289730	http://www.ebi.ac.uk/ena/data/view/AK289730
EMBL	AK289815	http://www.ebi.ac.uk/ena/data/view/AK289815
EMBL	BC099705	http://www.ebi.ac.uk/ena/data/view/BC099705
EMBL	BC099719	http://www.ebi.ac.uk/ena/data/view/BC099719
EMBL	BC105639	http://www.ebi.ac.uk/ena/data/view/BC105639
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	GU086163	http://www.ebi.ac.uk/ena/data/view/GU086163
EMBL	GU086164	http://www.ebi.ac.uk/ena/data/view/GU086164
EMBL	S67368	http://www.ebi.ac.uk/ena/data/view/S67368
EMBL	S77553	http://www.ebi.ac.uk/ena/data/view/S77553
EMBL	S77554	http://www.ebi.ac.uk/ena/data/view/S77554
Ensembl	ENST00000274547	http://www.ensembl.org/id/ENST00000274547
Ensembl	ENST00000353437	http://www.ensembl.org/id/ENST00000353437
Ensembl	ENST00000393959	http://www.ensembl.org/id/ENST00000393959
Ensembl	ENST00000520240	http://www.ensembl.org/id/ENST00000520240
Ensembl	ENST00000612710	http://www.ensembl.org/id/ENST00000612710
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_component	GO:1902711	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902711
GO_function	GO:0004890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004890
GO_function	GO:0005237	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005237
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007214	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007214
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007605
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0043524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043524
GO_process	GO:0051932	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051932
GO_process	GO:0060119	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060119
GO_process	GO:0060384	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060384
GO_process	GO:0071420	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071420
GO_process	GO:0090102	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090102
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	GABRB2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GABRB2
GeneID	2561	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2561
GeneTree	ENSGT00760000118821	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118821
HGNC	HGNC:4082	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4082
HOVERGEN	HBG051707	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051707&db=HOVERGEN
HPA	CAB001964	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB001964
HPA	HPA067632	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA067632
InParanoid	P47870	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P47870
IntAct	P47870	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P47870*
InterPro	IPR002289	http://www.ebi.ac.uk/interpro/entry/IPR002289
InterPro	IPR006028	http://www.ebi.ac.uk/interpro/entry/IPR006028
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
Jabion	2561	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2561
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:2561	http://www.genome.jp/dbget-bin/www_bget?hsa:2561
KEGG_Orthology	KO:K05181	http://www.genome.jp/dbget-bin/www_bget?KO:K05181
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04726	http://www.genome.jp/kegg-bin/show_pathway?ko04726
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
KEGG_Pathway	ko05032	http://www.genome.jp/kegg-bin/show_pathway?ko05032
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
MIM	600232	http://www.ncbi.nlm.nih.gov/omim/600232
MINT	MINT-268409	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-268409
OMA	HMTQKKS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HMTQKKS
OrthoDB	EOG091G0805	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0805
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00253	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00253
PRINTS	PR01160	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01160
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:GBRB2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GBRB2_HUMAN
PSORT-B	swissprot:GBRB2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GBRB2_HUMAN
PSORT2	swissprot:GBRB2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GBRB2_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA28496	http://www.pharmgkb.org/do/serve?objId=PA28496&objCls=Gene
Phobius	swissprot:GBRB2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GBRB2_HUMAN
PhylomeDB	P47870	http://phylomedb.org/?seqid=P47870
ProteinModelPortal	P47870	http://www.proteinmodelportal.org/query/uniprot/P47870
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16983389	http://www.ncbi.nlm.nih.gov/pubmed/16983389
PubMed	19763268	http://www.ncbi.nlm.nih.gov/pubmed/19763268
PubMed	7707873	http://www.ncbi.nlm.nih.gov/pubmed/7707873
PubMed	8264558	http://www.ncbi.nlm.nih.gov/pubmed/8264558
Reactome	R-HSA-112314	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112314
Reactome	R-HSA-975298	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-975298
Reactome	R-HSA-977441	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-977441
RefSeq	NP_000804	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000804
RefSeq	NP_068711	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_068711
SMR	P47870	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P47870
STRING	9606.ENSP00000274547	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000274547&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TCDB	1.A.9.5	http://www.tcdb.org/search/result.php?tc=1.A.9.5
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc003lyr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003lyr&org=rat
UniGene	Hs.303527	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.303527
UniProtKB	GBRB2_HUMAN	http://www.uniprot.org/uniprot/GBRB2_HUMAN
UniProtKB-AC	P47870	http://www.uniprot.org/uniprot/P47870
charge	swissprot:GBRB2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GBRB2_HUMAN
eggNOG	ENOG410XPWH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPWH
eggNOG	KOG3643	http://eggnogapi.embl.de/nog_data/html/tree/KOG3643
epestfind	swissprot:GBRB2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GBRB2_HUMAN
garnier	swissprot:GBRB2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GBRB2_HUMAN
helixturnhelix	swissprot:GBRB2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GBRB2_HUMAN
hmoment	swissprot:GBRB2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GBRB2_HUMAN
iep	swissprot:GBRB2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GBRB2_HUMAN
inforesidue	swissprot:GBRB2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GBRB2_HUMAN
neXtProt	NX_P47870	http://www.nextprot.org/db/entry/NX_P47870
octanol	swissprot:GBRB2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GBRB2_HUMAN
pepcoil	swissprot:GBRB2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GBRB2_HUMAN
pepdigest	swissprot:GBRB2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GBRB2_HUMAN
pepinfo	swissprot:GBRB2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GBRB2_HUMAN
pepnet	swissprot:GBRB2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GBRB2_HUMAN
pepstats	swissprot:GBRB2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GBRB2_HUMAN
pepwheel	swissprot:GBRB2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GBRB2_HUMAN
pepwindow	swissprot:GBRB2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GBRB2_HUMAN
sigcleave	swissprot:GBRB2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GBRB2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	B3A4_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q96Q91-1; Sequence=Displayed; Name=2; IsoId=Q96Q91-2; Sequence=VSP_007085, VSP_007086, VSP_007087; Name=3; IsoId=Q96Q91-3; Sequence=VSP_007085; Name=4; IsoId=Q96Q91-4; Sequence=VSP_007085, VSP_044785; Note=No experimental confirmation available.; 
# AltName	B3A4_HUMAN	Sodium bicarbonate cotransporter 5
# AltName	B3A4_HUMAN	Solute carrier family 4 member 9
# CCDS	CCDS47278	-. [Q96Q91-3]
# CCDS	CCDS58973	-. [Q96Q91-1]
# CCDS	CCDS58974	-. [Q96Q91-4]
# CCDS	CCDS58975	-. [Q96Q91-2]
# Ensembl	ENST00000432095	ENSP00000410056; ENSG00000113073. [Q96Q91-2]
# Ensembl	ENST00000506545	ENSP00000422855; ENSG00000113073. [Q96Q91-4]
# Ensembl	ENST00000506757	ENSP00000424424; ENSG00000113073. [Q96Q91-3]
# Ensembl	ENST00000507527	ENSP00000427661; ENSG00000113073. [Q96Q91-1]
# FUNCTION	B3A4_HUMAN	Probable apical anion exchanger of the kidney cortex. {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0045177	apical part of cell; IEA:Ensembl.
# GO_function	B3A4_HUMAN	GO 0008510 sodium bicarbonate symporter activity; TAS Reactome.
# GO_function	B3A4_HUMAN	GO 0015301 anion anion antiporter activity; IEA UniProtKB-KW.
# GO_function	GO:0005452	inorganic anion exchanger activity; IEA:InterPro.
# GO_function	GO:0008509	anion transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0015701	bicarbonate transport; IBA:GO_Central.
# GO_process	GO:0051453	regulation of intracellular pH; IBA:GO_Central.
# GO_process	GO:0098656	anion transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.1100.10	-; 1.
# Genevisible	Q96Q91	HS
# HGNC	HGNC:11035	SLC4A9
# InterPro	IPR003020	HCO3_transpt_euk
# InterPro	IPR003024	Na/HCO3_transpt
# InterPro	IPR011531	HCO3_transpt_C
# InterPro	IPR013769	Band3_cytoplasmic_dom
# InterPro	IPR016152	PTrfase/Anion_transptr
# KEGG_Brite	ko02001	Solute carrier family
# MIM	610207	gene
# Organism	B3A4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11453	PTHR11453; 2
# PRINTS	PR01231	HCO3TRNSPORT
# PRINTS	PR01232	NAHCO3TRSPRT
# Pfam	PF00955	HCO3_cotransp
# Pfam	PF07565	Band_3_cyto; 2
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-425381	Bicarbonate transporters
# RecName	B3A4_HUMAN	Anion exchange protein 4
# RefSeq	NP_001245355	NM_001258426.1. [Q96Q91-2]
# RefSeq	NP_001245356	NM_001258427.1. [Q96Q91-4]
# RefSeq	NP_001245357	NM_001258428.1. [Q96Q91-1]
# RefSeq	NP_113655	NM_031467.2. [Q96Q91-3]
# SEQUENCE CAUTION	Sequence=AAK28832.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the anion exchanger (TC 2.A.31) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	B3A4_HUMAN	Membrane; Multi-pass membrane protein. 
# SUPFAM	SSF55804	SSF55804
# TCDB	2.A.31.2.13	the anion exchanger (ae) family
# TIGRFAMs	TIGR00834	ae
# TISSUE SPECIFICITY	Kidney specific. {ECO:0000269|PubMed	11305939, ECO:0000269|Ref.7}. 
# UCSC	uc003lfk	human. [Q96Q91-1]
# eggNOG	ENOG410XPHD	LUCA
# eggNOG	KOG1172	Eukaryota
BLAST	swissprot:B3A4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:B3A4_HUMAN
COXPRESdb	83697	http://coxpresdb.jp/data/gene/83697.shtml
CleanEx	HS_SLC4A9	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC4A9
DOI	10.1006/bbrc.2001.4692	http://dx.doi.org/10.1006/bbrc.2001.4692
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/gb-2001-2-4-research0011	http://dx.doi.org/10.1186/gb-2001-2-4-research0011
EMBL	AB032762	http://www.ebi.ac.uk/ena/data/view/AB032762
EMBL	AC008438	http://www.ebi.ac.uk/ena/data/view/AC008438
EMBL	AF313465	http://www.ebi.ac.uk/ena/data/view/AF313465
EMBL	AF332961	http://www.ebi.ac.uk/ena/data/view/AF332961
EMBL	AF336237	http://www.ebi.ac.uk/ena/data/view/AF336237
EMBL	BC136262	http://www.ebi.ac.uk/ena/data/view/BC136262
EMBL	BC143602	http://www.ebi.ac.uk/ena/data/view/BC143602
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
Ensembl	ENST00000432095	http://www.ensembl.org/id/ENST00000432095
Ensembl	ENST00000506545	http://www.ensembl.org/id/ENST00000506545
Ensembl	ENST00000506757	http://www.ensembl.org/id/ENST00000506757
Ensembl	ENST00000507527	http://www.ensembl.org/id/ENST00000507527
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0045177	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045177
GO_function	GO:0005452	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005452
GO_function	GO:0008509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008509
GO_function	GO:0008510	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008510
GO_function	GO:0015301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015301
GO_process	GO:0015701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015701
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GO_process	GO:0098656	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098656
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.1100.10	http://www.cathdb.info/version/latest/superfamily/3.40.1100.10
GeneCards	SLC4A9	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC4A9
GeneID	83697	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83697
GeneTree	ENSGT00760000119021	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119021
H-InvDB	HIX0031939	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0031939
HGNC	HGNC:11035	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11035
HOGENOM	HOG000280684	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280684&db=HOGENOM6
HOVERGEN	HBG004326	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004326&db=HOVERGEN
HPA	HPA051307	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA051307
InParanoid	Q96Q91	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96Q91
InterPro	IPR003020	http://www.ebi.ac.uk/interpro/entry/IPR003020
InterPro	IPR003024	http://www.ebi.ac.uk/interpro/entry/IPR003024
InterPro	IPR011531	http://www.ebi.ac.uk/interpro/entry/IPR011531
InterPro	IPR013769	http://www.ebi.ac.uk/interpro/entry/IPR013769
InterPro	IPR016152	http://www.ebi.ac.uk/interpro/entry/IPR016152
Jabion	83697	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=83697
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:83697	http://www.genome.jp/dbget-bin/www_bget?hsa:83697
KEGG_Orthology	KO:K13860	http://www.genome.jp/dbget-bin/www_bget?KO:K13860
MIM	610207	http://www.ncbi.nlm.nih.gov/omim/610207
OMA	QELLWLD	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QELLWLD
OrthoDB	EOG091G01FT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01FT
PANTHER	PTHR11453	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11453
PRINTS	PR01231	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01231
PRINTS	PR01232	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01232
PSORT	swissprot:B3A4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:B3A4_HUMAN
PSORT-B	swissprot:B3A4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:B3A4_HUMAN
PSORT2	swissprot:B3A4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:B3A4_HUMAN
Pfam	PF00955	http://pfam.xfam.org/family/PF00955
Pfam	PF07565	http://pfam.xfam.org/family/PF07565
PharmGKB	PA35901	http://www.pharmgkb.org/do/serve?objId=PA35901&objCls=Gene
Phobius	swissprot:B3A4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:B3A4_HUMAN
PhylomeDB	Q96Q91	http://phylomedb.org/?seqid=Q96Q91
ProteinModelPortal	Q96Q91	http://www.proteinmodelportal.org/query/uniprot/Q96Q91
PubMed	11302728	http://www.ncbi.nlm.nih.gov/pubmed/11302728
PubMed	11305939	http://www.ncbi.nlm.nih.gov/pubmed/11305939
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-425381	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425381
RefSeq	NP_001245355	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001245355
RefSeq	NP_001245356	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001245356
RefSeq	NP_001245357	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001245357
RefSeq	NP_113655	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_113655
STRING	9606.ENSP00000424424	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000424424&targetmode=cogs
SUPFAM	SSF55804	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55804
TCDB	2.A.31.2.13	http://www.tcdb.org/search/result.php?tc=2.A.31.2.13
TIGRFAMs	TIGR00834	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00834
UCSC	uc003lfk	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003lfk&org=rat
UniGene	Hs.550313	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.550313
UniProtKB	B3A4_HUMAN	http://www.uniprot.org/uniprot/B3A4_HUMAN
UniProtKB-AC	Q96Q91	http://www.uniprot.org/uniprot/Q96Q91
charge	swissprot:B3A4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:B3A4_HUMAN
eggNOG	ENOG410XPHD	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPHD
eggNOG	KOG1172	http://eggnogapi.embl.de/nog_data/html/tree/KOG1172
epestfind	swissprot:B3A4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:B3A4_HUMAN
garnier	swissprot:B3A4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:B3A4_HUMAN
helixturnhelix	swissprot:B3A4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:B3A4_HUMAN
hmoment	swissprot:B3A4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:B3A4_HUMAN
iep	swissprot:B3A4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:B3A4_HUMAN
inforesidue	swissprot:B3A4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:B3A4_HUMAN
neXtProt	NX_Q96Q91	http://www.nextprot.org/db/entry/NX_Q96Q91
octanol	swissprot:B3A4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:B3A4_HUMAN
pepcoil	swissprot:B3A4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:B3A4_HUMAN
pepdigest	swissprot:B3A4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:B3A4_HUMAN
pepinfo	swissprot:B3A4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:B3A4_HUMAN
pepnet	swissprot:B3A4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:B3A4_HUMAN
pepstats	swissprot:B3A4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:B3A4_HUMAN
pepwheel	swissprot:B3A4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:B3A4_HUMAN
pepwindow	swissprot:B3A4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:B3A4_HUMAN
sigcleave	swissprot:B3A4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:B3A4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	NPT2A_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q06495-1; Sequence=Displayed; Name=2; IsoId=Q06495-2; Sequence=VSP_042311; 
# AltName	NPT2A_HUMAN	Na(+)-dependent phosphate cotransporter 2A
# AltName	NPT2A_HUMAN	NaPi-3
# AltName	NPT2A_HUMAN	Sodium/phosphate cotransporter 2A
# AltName	NPT2A_HUMAN	Solute carrier family 34 member 1
# CCDS	CCDS4418	-. [Q06495-1]
# CCDS	CCDS54953	-. [Q06495-2]
# DISEASE	NPT2A_HUMAN	Fanconi renotubular syndrome 2 (FRTS2) [MIM 613388]  A disease due to a generalized dysfunction of the proximal kidney tubule resulting in decreased solute and water reabsorption. Patients have polydipsia and polyuria with phosphaturia, glycosuria and aminoaciduria. They may develop hypophosphatemic rickets or osteomalacia, acidosis and a tendency toward dehydration. Some eventually develop renal insufficiency. {ECO 0000269|PubMed 20335586}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	NPT2A_HUMAN	Nephrolithiasis/osteoporosis, hypophosphatemic, 1 (NPHLOP1) [MIM 612286]  A disease characterized by decreased renal phosphate absorption, renal phosphate wasting, hypophosphatemia, hyperphosphaturia, hypercalciuria, nephrolithiasis and osteoporosis. {ECO 0000269|PubMed 12324554}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000324417	ENSP00000321424; ENSG00000131183. [Q06495-1]
# Ensembl	ENST00000512593	ENSP00000423022; ENSG00000131183. [Q06495-2]
# ExpressionAtlas	Q06495	baseline and differential
# FUNCTION	NPT2A_HUMAN	May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx. 
# GO_component	GO:0005737	cytoplasm; IBA:GO_Central.
# GO_component	GO:0005768	endosome; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; NAS:UniProtKB.
# GO_component	GO:0005903	brush border; IBA:GO_Central.
# GO_component	GO:0009986	cell surface; IEA:Ensembl.
# GO_component	GO:0016324	apical plasma membrane; IBA:GO_Central.
# GO_component	GO:0031526	brush border membrane; ISS:UniProtKB.
# GO_component	GO:0031982	vesicle; IBA:GO_Central.
# GO_component	GO:0045121	membrane raft; IEA:Ensembl.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IEA:Ensembl.
# GO_function	GO:0005315	inorganic phosphate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015321	sodium-dependent phosphate transmembrane transporter activity; IDA:UniProtKB.
# GO_function	NPT2A_HUMAN	GO 0005436 sodium phosphate symporter activity; IBA GO_Central.
# GO_process	GO:0001503	ossification; IEA:Ensembl.
# GO_process	GO:0001822	kidney development; IEA:Ensembl.
# GO_process	GO:0006817	phosphate ion transport; IDA:UniProtKB.
# GO_process	GO:0009100	glycoprotein metabolic process; IEA:Ensembl.
# GO_process	GO:0010288	response to lead ion; IDA:UniProtKB.
# GO_process	GO:0030643	cellular phosphate ion homeostasis; IBA:GO_Central.
# GO_process	GO:0032026	response to magnesium ion; IEA:Ensembl.
# GO_process	GO:0032355	response to estradiol; IEA:Ensembl.
# GO_process	GO:0033189	response to vitamin A; IEA:Ensembl.
# GO_process	GO:0035864	response to potassium ion; IEA:Ensembl.
# GO_process	GO:0042431	indole metabolic process; IEA:Ensembl.
# GO_process	GO:0042493	response to drug; IEA:Ensembl.
# GO_process	GO:0044267	cellular protein metabolic process; TAS:Reactome.
# GO_process	GO:0045838	positive regulation of membrane potential; IEA:Ensembl.
# GO_process	GO:0046686	response to cadmium ion; IDA:UniProtKB.
# GO_process	GO:0046689	response to mercury ion; IDA:UniProtKB.
# GO_process	GO:0051260	protein homooligomerization; IEA:Ensembl.
# GO_process	GO:0055062	phosphate ion homeostasis; IDA:UniProtKB.
# GO_process	GO:0060416	response to growth hormone; IEA:Ensembl.
# GO_process	GO:0071248	cellular response to metal ion; IEA:Ensembl.
# GO_process	GO:0071374	cellular response to parathyroid hormone stimulus; IEA:Ensembl.
# GO_process	GO:0072350	tricarboxylic acid metabolic process; IEA:Ensembl.
# GO_process	GO:0072734	cellular response to staurosporine; IEA:Ensembl.
# GO_process	GO:0097066	response to thyroid hormone; IEA:Ensembl.
# GO_process	GO:0097187	dentinogenesis; IEA:Ensembl.
# GO_process	GO:1901128	gentamycin metabolic process; IEA:Ensembl.
# GO_process	GO:1901684	arsenate ion transmembrane transport; IEA:Ensembl.
# GO_process	GO:2000120	positive regulation of sodium-dependent phosphate transport; IEA:Ensembl.
# GO_process	GO:2000187	positive regulation of phosphate transmembrane transport; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0048646	anatomical structure formation involved in morphogenesis
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q06495	HS
# HGNC	HGNC:11019	SLC34A1
# InterPro	IPR003841	Na/Pi_transpt
# InterPro	IPR029848	Na/Pi_transpt_2A
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H00888	[Kidney disease; Skeletal dysplasia] Nephrolithiasis/osteoporosis, hypophosphatemic
# KEGG_Disease	H01198	[Inherited metabolic disease; Kidney disease] Fanconi renotubular syndrome (FTS)
# MIM	182309	gene
# MIM	612286	phenotype
# MIM	613388	phenotype
# Organism	NPT2A_HUMAN	Homo sapiens (Human)
# Orphanet	244305	Dominant hypophosphatemia with nephrolithiasis or osteoporosis
# Orphanet	3337	Primary Fanconi syndrome
# PANTHER	PTHR10010:SF21	PTHR10010:SF21
# PIR	B48189	B48189
# Pfam	PF02690	Na_Pi_cotrans; 2
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-427589	Type II Na+/Pi cotransporters
# Reactome	R-HSA-5683826	Surfactant metabolism
# RecName	NPT2A_HUMAN	Sodium-dependent phosphate transport protein 2A
# RefSeq	NP_001161051	NM_001167579.1. [Q06495-2]
# RefSeq	NP_003043	NM_003052.4. [Q06495-1]
# SIMILARITY	Belongs to the SLC34A transporter family. {ECO	0000305}.
# SUBCELLULAR LOCATION	NPT2A_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Interacts via its C-terminal region with PDZK2 (By similarity). Interacts with SLC9A3R1. {ECO:0000250, ECO	0000269|PubMed:22506049}. 
# TCDB	2.A.58.1:the phosphate	na(+) symporter (pnas) family
# TIGRFAMs	TIGR01013	2a58
# TISSUE SPECIFICITY	NPT2A_HUMAN	Kidney and lung. 
# UCSC	uc003mgk	human. [Q06495-1]
# eggNOG	COG1283	LUCA
# eggNOG	ENOG410IE8P	Eukaryota
BLAST	swissprot:NPT2A_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NPT2A_HUMAN
BioCyc	ZFISH:ENSG00000131183-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000131183-MONOMER
COG	COG1283	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1283
COXPRESdb	6569	http://coxpresdb.jp/data/gene/6569.shtml
CleanEx	HS_SLC17A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC17A2
CleanEx	HS_SLC34A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC34A1
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1056/NEJMoa020028	http://dx.doi.org/10.1056/NEJMoa020028
DOI	10.1056/NEJMoa0905647	http://dx.doi.org/10.1056/NEJMoa0905647
DOI	10.1073/pnas.90.13.5979	http://dx.doi.org/10.1073/pnas.90.13.5979
DOI	10.1371/journal.pone.0034764	http://dx.doi.org/10.1371/journal.pone.0034764
EMBL	AC145098	http://www.ebi.ac.uk/ena/data/view/AC145098
EMBL	AK298299	http://www.ebi.ac.uk/ena/data/view/AK298299
EMBL	L13258	http://www.ebi.ac.uk/ena/data/view/L13258
Ensembl	ENST00000324417	http://www.ensembl.org/id/ENST00000324417
Ensembl	ENST00000512593	http://www.ensembl.org/id/ENST00000512593
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005903	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005903
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0031526	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031526
GO_component	GO:0031982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031982
GO_component	GO:0045121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045121
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_function	GO:0005315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005315
GO_function	GO:0005436	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005436
GO_function	GO:0015321	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015321
GO_process	GO:0001503	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001503
GO_process	GO:0001822	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001822
GO_process	GO:0006817	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006817
GO_process	GO:0009100	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009100
GO_process	GO:0010288	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010288
GO_process	GO:0030643	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030643
GO_process	GO:0032026	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032026
GO_process	GO:0032355	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032355
GO_process	GO:0033189	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033189
GO_process	GO:0035864	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035864
GO_process	GO:0042431	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042431
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0044267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044267
GO_process	GO:0045838	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045838
GO_process	GO:0046686	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046686
GO_process	GO:0046689	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046689
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:0055062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055062
GO_process	GO:0060416	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060416
GO_process	GO:0071248	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071248
GO_process	GO:0071374	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071374
GO_process	GO:0072350	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072350
GO_process	GO:0072734	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072734
GO_process	GO:0097066	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097066
GO_process	GO:0097187	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097187
GO_process	GO:1901128	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901128
GO_process	GO:1901684	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901684
GO_process	GO:2000120	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000120
GO_process	GO:2000187	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000187
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0048646	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048646
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC34A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC34A1
GeneID	6569	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6569
GeneTree	ENSGT00390000005032	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000005032
HGNC	HGNC:11019	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11019
HOGENOM	HOG000006550	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006550&db=HOGENOM6
HOVERGEN	HBG079110	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG079110&db=HOVERGEN
HPA	HPA051255	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA051255
InParanoid	Q06495	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q06495
InterPro	IPR003841	http://www.ebi.ac.uk/interpro/entry/IPR003841
InterPro	IPR029848	http://www.ebi.ac.uk/interpro/entry/IPR029848
Jabion	6569	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6569
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00888	http://www.genome.jp/dbget-bin/www_bget?H00888
KEGG_Disease	H01198	http://www.genome.jp/dbget-bin/www_bget?H01198
KEGG_Gene	hsa:6569	http://www.genome.jp/dbget-bin/www_bget?hsa:6569
KEGG_Orthology	KO:K14683	http://www.genome.jp/dbget-bin/www_bget?KO:K14683
MIM	182309	http://www.ncbi.nlm.nih.gov/omim/182309
MIM	612286	http://www.ncbi.nlm.nih.gov/omim/612286
MIM	613388	http://www.ncbi.nlm.nih.gov/omim/613388
OMA	CPYGEVL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CPYGEVL
Orphanet	244305	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=244305
Orphanet	3337	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=3337
OrthoDB	EOG091G0DR5	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0DR5
PANTHER	PTHR10010:SF21	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10010:SF21
PSORT	swissprot:NPT2A_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NPT2A_HUMAN
PSORT-B	swissprot:NPT2A_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NPT2A_HUMAN
PSORT2	swissprot:NPT2A_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NPT2A_HUMAN
Pfam	PF02690	http://pfam.xfam.org/family/PF02690
PharmGKB	PA35887	http://www.pharmgkb.org/do/serve?objId=PA35887&objCls=Gene
Phobius	swissprot:NPT2A_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NPT2A_HUMAN
PhylomeDB	Q06495	http://phylomedb.org/?seqid=Q06495
ProteinModelPortal	Q06495	http://www.proteinmodelportal.org/query/uniprot/Q06495
PubMed	12324554	http://www.ncbi.nlm.nih.gov/pubmed/12324554
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	20335586	http://www.ncbi.nlm.nih.gov/pubmed/20335586
PubMed	22506049	http://www.ncbi.nlm.nih.gov/pubmed/22506049
PubMed	8327470	http://www.ncbi.nlm.nih.gov/pubmed/8327470
Reactome	R-HSA-427589	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-427589
Reactome	R-HSA-5683826	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5683826
RefSeq	NP_001161051	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001161051
RefSeq	NP_003043	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003043
STRING	9606.ENSP00000321424	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000321424&targetmode=cogs
STRING	COG1283	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1283&targetmode=cogs
TCDB	2.A.58.1	http://www.tcdb.org/search/result.php?tc=2.A.58.1
TIGRFAMs	TIGR01013	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01013
UCSC	uc003mgk	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003mgk&org=rat
UniGene	Hs.936	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.936
UniProtKB	NPT2A_HUMAN	http://www.uniprot.org/uniprot/NPT2A_HUMAN
UniProtKB-AC	Q06495	http://www.uniprot.org/uniprot/Q06495
charge	swissprot:NPT2A_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NPT2A_HUMAN
eggNOG	COG1283	http://eggnogapi.embl.de/nog_data/html/tree/COG1283
eggNOG	ENOG410IE8P	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IE8P
epestfind	swissprot:NPT2A_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NPT2A_HUMAN
garnier	swissprot:NPT2A_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NPT2A_HUMAN
helixturnhelix	swissprot:NPT2A_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NPT2A_HUMAN
hmoment	swissprot:NPT2A_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NPT2A_HUMAN
iep	swissprot:NPT2A_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NPT2A_HUMAN
inforesidue	swissprot:NPT2A_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NPT2A_HUMAN
neXtProt	NX_Q06495	http://www.nextprot.org/db/entry/NX_Q06495
octanol	swissprot:NPT2A_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NPT2A_HUMAN
pepcoil	swissprot:NPT2A_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NPT2A_HUMAN
pepdigest	swissprot:NPT2A_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NPT2A_HUMAN
pepinfo	swissprot:NPT2A_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NPT2A_HUMAN
pepnet	swissprot:NPT2A_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NPT2A_HUMAN
pepstats	swissprot:NPT2A_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NPT2A_HUMAN
pepwheel	swissprot:NPT2A_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NPT2A_HUMAN
pepwindow	swissprot:NPT2A_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NPT2A_HUMAN
sigcleave	swissprot:NPT2A_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NPT2A_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S22AA_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q63ZE4-1; Sequence=Displayed; Name=2; IsoId=Q63ZE4-2; Sequence=VSP_056645, VSP_056646, VSP_056647; 
# AltName	S22AA_HUMAN	Organic anion transporter 5
# CCDS	CCDS41661	-. [Q63ZE4-1]
# CDD	cd06174	MFS
# DrugBank	DB00286	Conjugated Estrogens
# DrugBank	DB00936	Salicylic acid
# DrugBank	DB01032	Probenecid
# Ensembl	ENST00000332793	ENSP00000327569; ENSG00000184999. [Q63ZE4-1]
# ExpressionAtlas	Q63ZE4	baseline and differential
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0005452	inorganic anion exchanger activity; IBA:GO_Central.
# GO_function	GO:0015347	sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0043252	sodium-independent organic anion transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# HGNC	HGNC:18057	SLC22A10
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	607580	gene
# Organism	S22AA_HUMAN	Homo sapiens (Human)
# PROSITE	PS50850	MFS
# Pfam	PF00083	Sugar_tr
# Proteomes	UP000005640	Chromosome 11
# RecName	S22AA_HUMAN	Solute carrier family 22 member 10
# RefSeq	NP_001034841	NM_001039752.3. [Q63ZE4-1]
# RefSeq	XP_011543318	XM_011545016.2. [Q63ZE4-1]
# SIMILARITY	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S22AA_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.19.27	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	S22AA_HUMAN	Detected in fetal and adult liver, and in adult kidney. {ECO 0000269|PubMed 11327718, ECO 0000269|PubMed 12372408}. 
# UCSC	uc009yor	human. [Q63ZE4-1]
# eggNOG	COG0477	LUCA
# eggNOG	KOG0255	Eukaryota
BLAST	swissprot:S22AA_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S22AA_HUMAN
BioCyc	ZFISH:G66-32580-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32580-MONOMER
COXPRESdb	387775	http://coxpresdb.jp/data/gene/387775.shtml
CleanEx	HS_SLC22A10	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC22A10
DOI	10.1006/bbrc.2001.4774	http://dx.doi.org/10.1006/bbrc.2001.4774
DOI	10.1016/S0006-291X(02)02343-4	http://dx.doi.org/10.1016/S0006-291X(02)02343-4
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1038/sj.onc.1207782	http://dx.doi.org/10.1038/sj.onc.1207782
DrugBank	DB00286	http://www.drugbank.ca/drugs/DB00286
DrugBank	DB00936	http://www.drugbank.ca/drugs/DB00936
DrugBank	DB01032	http://www.drugbank.ca/drugs/DB01032
EMBL	AB075876	http://www.ebi.ac.uk/ena/data/view/AB075876
EMBL	AP001858	http://www.ebi.ac.uk/ena/data/view/AP001858
EMBL	AP001880	http://www.ebi.ac.uk/ena/data/view/AP001880
EMBL	AP003420	http://www.ebi.ac.uk/ena/data/view/AP003420
EMBL	BK001421	http://www.ebi.ac.uk/ena/data/view/BK001421
Ensembl	ENST00000332793	http://www.ensembl.org/id/ENST00000332793
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005452	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005452
GO_function	GO:0015347	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015347
GO_process	GO:0043252	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043252
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC22A10	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC22A10
GeneID	387775	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=387775
GeneTree	ENSGT00760000118852	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118852
H-InvDB	HIX0035825	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0035825
HGNC	HGNC:18057	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18057
HOGENOM	HOG000234569	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234569&db=HOGENOM6
HOVERGEN	HBG108433	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108433&db=HOVERGEN
InParanoid	Q63ZE4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q63ZE4
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	387775	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=387775
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:387775	http://www.genome.jp/dbget-bin/www_bget?hsa:387775
KEGG_Orthology	KO:K08206	http://www.genome.jp/dbget-bin/www_bget?KO:K08206
MIM	607580	http://www.ncbi.nlm.nih.gov/omim/607580
OMA	SVAVHFI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SVAVHFI
OrthoDB	EOG091G04H6	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G04H6
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:S22AA_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S22AA_HUMAN
PSORT-B	swissprot:S22AA_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S22AA_HUMAN
PSORT2	swissprot:S22AA_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S22AA_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
PharmGKB	PA38283	http://www.pharmgkb.org/do/serve?objId=PA38283&objCls=Gene
Phobius	swissprot:S22AA_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S22AA_HUMAN
PhylomeDB	Q63ZE4	http://phylomedb.org/?seqid=Q63ZE4
ProteinModelPortal	Q63ZE4	http://www.proteinmodelportal.org/query/uniprot/Q63ZE4
PubMed	11327718	http://www.ncbi.nlm.nih.gov/pubmed/11327718
PubMed	12372408	http://www.ncbi.nlm.nih.gov/pubmed/12372408
PubMed	15221005	http://www.ncbi.nlm.nih.gov/pubmed/15221005
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
RefSeq	NP_001034841	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001034841
RefSeq	XP_011543318	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011543318
STRING	9606.ENSP00000327569	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000327569&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.19.27	http://www.tcdb.org/search/result.php?tc=2.A.1.19.27
UCSC	uc009yor	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc009yor&org=rat
UniGene	Hs.188982	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.188982
UniProtKB	S22AA_HUMAN	http://www.uniprot.org/uniprot/S22AA_HUMAN
UniProtKB-AC	Q63ZE4	http://www.uniprot.org/uniprot/Q63ZE4
charge	swissprot:S22AA_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S22AA_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG0255	http://eggnogapi.embl.de/nog_data/html/tree/KOG0255
epestfind	swissprot:S22AA_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S22AA_HUMAN
garnier	swissprot:S22AA_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S22AA_HUMAN
helixturnhelix	swissprot:S22AA_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S22AA_HUMAN
hmoment	swissprot:S22AA_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S22AA_HUMAN
iep	swissprot:S22AA_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S22AA_HUMAN
inforesidue	swissprot:S22AA_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S22AA_HUMAN
neXtProt	NX_Q63ZE4	http://www.nextprot.org/db/entry/NX_Q63ZE4
octanol	swissprot:S22AA_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S22AA_HUMAN
pepcoil	swissprot:S22AA_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S22AA_HUMAN
pepdigest	swissprot:S22AA_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S22AA_HUMAN
pepinfo	swissprot:S22AA_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S22AA_HUMAN
pepnet	swissprot:S22AA_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S22AA_HUMAN
pepstats	swissprot:S22AA_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S22AA_HUMAN
pepwheel	swissprot:S22AA_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S22AA_HUMAN
pepwindow	swissprot:S22AA_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S22AA_HUMAN
sigcleave	swissprot:S22AA_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S22AA_HUMAN
## Database	ID	URL or Descriptions
# AltName	SC6A3_HUMAN	Solute carrier family 6 member 3
# BioGrid	112422	13
# DISEASE	SC6A3_HUMAN	Parkinsonism-dystonia infantile (PKDYS) [MIM 613135]  A neurodegenerative disorder characterized by infantile onset of parkinsonism and dystonia. Other neurologic features include global developmental delay, bradykinesia and pyramidal tract signs. {ECO 0000269|PubMed 19478460}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00182	Amphetamine
# DrugBank	DB00191	Phentermine
# DrugBank	DB00215	Citalopram
# DrugBank	DB00245	Benzatropine
# DrugBank	DB00285	Venlafaxine
# DrugBank	DB00289	Atomoxetine
# DrugBank	DB00370	Mirtazapine
# DrugBank	DB00408	Loxapine
# DrugBank	DB00422	Methylphenidate
# DrugBank	DB00454	Pethidine
# DrugBank	DB00458	Imipramine
# DrugBank	DB00476	Duloxetine
# DrugBank	DB00543	Amoxapine
# DrugBank	DB00579	Mazindol
# DrugBank	DB00721	Procaine
# DrugBank	DB00726	Trimipramine
# DrugBank	DB00745	Modafinil
# DrugBank	DB00830	Phenmetrazine
# DrugBank	DB00852	Pseudoephedrine
# DrugBank	DB00865	Benzphetamine
# DrugBank	DB00907	Cocaine
# DrugBank	DB00937	Diethylpropion
# DrugBank	DB00988	Dopamine
# DrugBank	DB01104	Sertraline
# DrugBank	DB01105	Sibutramine
# DrugBank	DB01114	Chlorphenamine
# DrugBank	DB01146	Diphenylpyraline
# DrugBank	DB01149	Nefazodone
# DrugBank	DB01156	Bupropion
# DrugBank	DB01161	Chloroprocaine
# DrugBank	DB01175	Escitalopram
# DrugBank	DB01255	Lisdexamfetamine
# DrugBank	DB01363	Ephedra
# DrugBank	DB01463	Fencamfamine
# DrugBank	DB01576	Dextroamphetamine
# DrugBank	DB01577	Methamphetamine
# DrugBank	DB06148	Mianserin
# DrugBank	DB06413	Armodafinil
# DrugBank	DB06701	Dexmethylphenidate
# DrugBank	DB08824	Ioflupane I 123
# Ensembl	ENST00000270349	ENSP00000270349; ENSG00000142319
# Ensembl	ENST00000621716	ENSP00000479597; ENSG00000276996
# FUNCTION	SC6A3_HUMAN	Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. {ECO 0000269|PubMed 1406597, ECO 0000269|PubMed 15505207, ECO 0000269|PubMed 8302271}. 
# GO_component	GO:0005737	cytoplasm; TAS:ProtInc.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0009986	cell surface; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_component	GO:0016600	flotillin complex; IDA:UniProtKB.
# GO_component	GO:0030424	axon; IDA:UniProtKB.
# GO_component	GO:0043005	neuron projection; IDA:ParkinsonsUK-UCL.
# GO_component	GO:0043025	neuronal cell body; IDA:UniProtKB.
# GO_component	GO:0045121	membrane raft; IDA:ParkinsonsUK-UCL.
# GO_component	GO:0098793	presynapse; IEA:GOC.
# GO_function	GO:0005329	dopamine transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0008144	drug binding; IEA:Ensembl.
# GO_function	GO:0008504	monoamine transmembrane transporter activity; IDA:MGI.
# GO_function	GO:0035240	dopamine binding; IEA:Ensembl.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_function	SC6A3_HUMAN	GO 0005330 dopamine sodium symporter activity; IBA GO_Central.
# GO_process	GO:0007568	aging; IEA:Ensembl.
# GO_process	GO:0007595	lactation; IEA:Ensembl.
# GO_process	GO:0007608	sensory perception of smell; IEA:Ensembl.
# GO_process	GO:0007626	locomotory behavior; IEA:Ensembl.
# GO_process	GO:0010039	response to iron ion; IEA:Ensembl.
# GO_process	GO:0015844	monoamine transport; IDA:MGI.
# GO_process	GO:0015872	dopamine transport; IDA:UniProtKB.
# GO_process	GO:0021984	adenohypophysis development; IEA:Ensembl.
# GO_process	GO:0035094	response to nicotine; IEA:Ensembl.
# GO_process	GO:0040018	positive regulation of multicellular organism growth; IEA:Ensembl.
# GO_process	GO:0042053	regulation of dopamine metabolic process; IEA:Ensembl.
# GO_process	GO:0042136	neurotransmitter biosynthetic process; TAS:Reactome.
# GO_process	GO:0042220	response to cocaine; IEA:Ensembl.
# GO_process	GO:0042416	dopamine biosynthetic process; IEA:Ensembl.
# GO_process	GO:0042420	dopamine catabolic process; IEA:Ensembl.
# GO_process	GO:0042493	response to drug; IEA:Ensembl.
# GO_process	GO:0045471	response to ethanol; IEA:Ensembl.
# GO_process	GO:0051583	dopamine uptake involved in synaptic transmission; IBA:GO_Central.
# GO_process	GO:0051591	response to cAMP; IEA:Ensembl.
# GO_process	GO:0060134	prepulse inhibition; IEA:Ensembl.
# GO_process	GO:0090494	dopamine uptake; IDA:ParkinsonsUK-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007568	aging
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009056	catabolic process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# Genevisible	Q01959	HS
# HGNC	HGNC:11049	SLC6A3
# INTERACTION	SC6A3_HUMAN	P14416 DRD2; NbExp=4; IntAct=EBI-6661445, EBI-2928178; P37840 SNCA; NbExp=3; IntAct=EBI-6661445, EBI-985879; 
# IntAct	Q01959	4
# InterPro	IPR000175	Na/ntran_symport
# InterPro	IPR002436	Na/ntran_symport_dopamine
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04728	Dopaminergic synapse
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05030	Cocaine addiction
# KEGG_Pathway	ko05031	Amphetamine addiction
# KEGG_Pathway	ko05034	Alcoholism
# MIM	126455	gene
# MIM	613135	phenotype
# MISCELLANEOUS	SC6A3_HUMAN	This protein is the target of psychomotor stimulants such as amphetamines or cocaine. 
# Organism	SC6A3_HUMAN	Homo sapiens (Human)
# Orphanet	238455	Infantile dystonia-parkinsonism
# PANTHER	PTHR11616	PTHR11616
# PIR	A48980	A48980
# PIR	I57937	I57937
# PIR	I84455	I84455
# PRINTS	PR00176	NANEUSMPORT
# PRINTS	PR01202	DOPTRANSPORT
# PROSITE	PS00610	NA_NEUROTRAN_SYMP_1
# PROSITE	PS00754	NA_NEUROTRAN_SYMP_2
# PROSITE	PS50267	NA_NEUROTRAN_SYMP_3
# Pfam	PF00209	SNF
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-379401	Dopamine clearance from the synaptic cleft
# Reactome	R-HSA-442660	Na+/Cl- dependent neurotransmitter transporters
# RecName	SC6A3_HUMAN	Sodium-dependent dopamine transporter
# RefSeq	NP_001035	NM_001044.4
# SIMILARITY	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	SC6A3_HUMAN	Cell membrane {ECO 0000269|PubMed 1406597, ECO 0000269|PubMed 15505207, ECO 0000269|PubMed 8302271}; Multi- pass membrane protein {ECO 0000269|PubMed 15505207}. 
# SUBUNIT	SC6A3_HUMAN	Homooligomer; disulfide-linked (Ref.14). Interacts with PRKCABP and TGFB1I1 (PubMed 11343649, PubMed 12177201). Interacts (via N-terminus) with SYNGR3 (via N-terminus). Interacts with SLC18A2. Interacts with TOR1A (ATP-bound); TOR1A regulates SLC6A3 subcellular location (By similarity). {ECO 0000250|UniProtKB Q61327, ECO 0000269|PubMed 11343649, ECO 0000269|PubMed 12177201, ECO 0000269|PubMed 15505207, ECO 0000269|Ref.14}. 
# TCDB	2.A.22.1:the neurotransmitter	sodium symporter (nss) family
# TISSUE SPECIFICITY	Highly expressed in substantia nigra. {ECO:0000269|PubMed	7637582}. 
# UCSC	uc003jck	human
# WEB RESOURCE	SC6A3_HUMAN	Name=NIEHS-SNPs; URL="http //egp.gs.washington.edu/data/slc6a3/"; 
# WEB RESOURCE	SC6A3_HUMAN	Name=Wikipedia; Note=Dopamine transporter entry; URL="https //en.wikipedia.org/wiki/Dopamine_transporter";
# eggNOG	COG0733	LUCA
# eggNOG	KOG3659	Eukaryota
BLAST	swissprot:SC6A3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SC6A3_HUMAN
BioCyc	ZFISH:ENSG00000142319-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000142319-MONOMER
COXPRESdb	6531	http://coxpresdb.jp/data/gene/6531.shtml
CleanEx	HS_SLC6A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC6A3
DIP	DIP-41827N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-41827N
DOI	10.1002/1096-8628(2001)9999:9999<::AID-AJMG1161>3.0.CO	http://dx.doi.org/10.1002/1096-8628(2001)9999:9999<::AID-AJMG1161>3.0.CO
DOI	10.1016/0169-328X(92)90165-8	http://dx.doi.org/10.1016/0169-328X(92)90165-8
DOI	10.1016/0169-328X(95)00018-N	http://dx.doi.org/10.1016/0169-328X(95)00018-N
DOI	10.1016/S0378-1119(97)00131-5	http://dx.doi.org/10.1016/S0378-1119(97)00131-5
DOI	10.1016/S0896-6273(01)00267-7	http://dx.doi.org/10.1016/S0896-6273(01)00267-7
DOI	10.1038/10290	http://dx.doi.org/10.1038/10290
DOI	10.1038/nature09629	http://dx.doi.org/10.1038/nature09629
DOI	10.1038/sj.mp.4000701	http://dx.doi.org/10.1038/sj.mp.4000701
DOI	10.1073/pnas.0308088101	http://dx.doi.org/10.1073/pnas.0308088101
DOI	10.1073/pnas.89.15.7095	http://dx.doi.org/10.1073/pnas.89.15.7095
DOI	10.1093/molbev/msm219	http://dx.doi.org/10.1093/molbev/msm219
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1172/JCI39060	http://dx.doi.org/10.1172/JCI39060
DrugBank	DB00182	http://www.drugbank.ca/drugs/DB00182
DrugBank	DB00191	http://www.drugbank.ca/drugs/DB00191
DrugBank	DB00215	http://www.drugbank.ca/drugs/DB00215
DrugBank	DB00245	http://www.drugbank.ca/drugs/DB00245
DrugBank	DB00285	http://www.drugbank.ca/drugs/DB00285
DrugBank	DB00289	http://www.drugbank.ca/drugs/DB00289
DrugBank	DB00370	http://www.drugbank.ca/drugs/DB00370
DrugBank	DB00408	http://www.drugbank.ca/drugs/DB00408
DrugBank	DB00422	http://www.drugbank.ca/drugs/DB00422
DrugBank	DB00454	http://www.drugbank.ca/drugs/DB00454
DrugBank	DB00458	http://www.drugbank.ca/drugs/DB00458
DrugBank	DB00476	http://www.drugbank.ca/drugs/DB00476
DrugBank	DB00543	http://www.drugbank.ca/drugs/DB00543
DrugBank	DB00579	http://www.drugbank.ca/drugs/DB00579
DrugBank	DB00721	http://www.drugbank.ca/drugs/DB00721
DrugBank	DB00726	http://www.drugbank.ca/drugs/DB00726
DrugBank	DB00745	http://www.drugbank.ca/drugs/DB00745
DrugBank	DB00830	http://www.drugbank.ca/drugs/DB00830
DrugBank	DB00852	http://www.drugbank.ca/drugs/DB00852
DrugBank	DB00865	http://www.drugbank.ca/drugs/DB00865
DrugBank	DB00907	http://www.drugbank.ca/drugs/DB00907
DrugBank	DB00937	http://www.drugbank.ca/drugs/DB00937
DrugBank	DB00988	http://www.drugbank.ca/drugs/DB00988
DrugBank	DB01104	http://www.drugbank.ca/drugs/DB01104
DrugBank	DB01105	http://www.drugbank.ca/drugs/DB01105
DrugBank	DB01114	http://www.drugbank.ca/drugs/DB01114
DrugBank	DB01146	http://www.drugbank.ca/drugs/DB01146
DrugBank	DB01149	http://www.drugbank.ca/drugs/DB01149
DrugBank	DB01156	http://www.drugbank.ca/drugs/DB01156
DrugBank	DB01161	http://www.drugbank.ca/drugs/DB01161
DrugBank	DB01175	http://www.drugbank.ca/drugs/DB01175
DrugBank	DB01255	http://www.drugbank.ca/drugs/DB01255
DrugBank	DB01363	http://www.drugbank.ca/drugs/DB01363
DrugBank	DB01463	http://www.drugbank.ca/drugs/DB01463
DrugBank	DB01576	http://www.drugbank.ca/drugs/DB01576
DrugBank	DB01577	http://www.drugbank.ca/drugs/DB01577
DrugBank	DB06148	http://www.drugbank.ca/drugs/DB06148
DrugBank	DB06413	http://www.drugbank.ca/drugs/DB06413
DrugBank	DB06701	http://www.drugbank.ca/drugs/DB06701
DrugBank	DB08824	http://www.drugbank.ca/drugs/DB08824
EMBL	AF119117	http://www.ebi.ac.uk/ena/data/view/AF119117
EMBL	AF306558	http://www.ebi.ac.uk/ena/data/view/AF306558
EMBL	AF306559	http://www.ebi.ac.uk/ena/data/view/AF306559
EMBL	AF306560	http://www.ebi.ac.uk/ena/data/view/AF306560
EMBL	AF306561	http://www.ebi.ac.uk/ena/data/view/AF306561
EMBL	AF306562	http://www.ebi.ac.uk/ena/data/view/AF306562
EMBL	AF306563	http://www.ebi.ac.uk/ena/data/view/AF306563
EMBL	AF306564	http://www.ebi.ac.uk/ena/data/view/AF306564
EMBL	AF321320	http://www.ebi.ac.uk/ena/data/view/AF321320
EMBL	AF321321	http://www.ebi.ac.uk/ena/data/view/AF321321
EMBL	AY623110	http://www.ebi.ac.uk/ena/data/view/AY623110
EMBL	BC132977	http://www.ebi.ac.uk/ena/data/view/BC132977
EMBL	BC133003	http://www.ebi.ac.uk/ena/data/view/BC133003
EMBL	CH471102	http://www.ebi.ac.uk/ena/data/view/CH471102
EMBL	D88570	http://www.ebi.ac.uk/ena/data/view/D88570
EMBL	EF174603	http://www.ebi.ac.uk/ena/data/view/EF174603
EMBL	L24178	http://www.ebi.ac.uk/ena/data/view/L24178
EMBL	M95167	http://www.ebi.ac.uk/ena/data/view/M95167
EMBL	M96670	http://www.ebi.ac.uk/ena/data/view/M96670
EMBL	S44626	http://www.ebi.ac.uk/ena/data/view/S44626
EMBL	S46955	http://www.ebi.ac.uk/ena/data/view/S46955
Ensembl	ENST00000270349	http://www.ensembl.org/id/ENST00000270349
Ensembl	ENST00000621716	http://www.ensembl.org/id/ENST00000621716
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016600	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016600
GO_component	GO:0030424	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030424
GO_component	GO:0043005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043005
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0045121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045121
GO_component	GO:0098793	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098793
GO_function	GO:0005329	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005329
GO_function	GO:0005330	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005330
GO_function	GO:0008144	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008144
GO_function	GO:0008504	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008504
GO_function	GO:0035240	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035240
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0007568	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007568
GO_process	GO:0007595	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007595
GO_process	GO:0007608	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007608
GO_process	GO:0007626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007626
GO_process	GO:0010039	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010039
GO_process	GO:0015844	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015844
GO_process	GO:0015872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015872
GO_process	GO:0021984	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021984
GO_process	GO:0035094	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035094
GO_process	GO:0040018	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040018
GO_process	GO:0042053	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042053
GO_process	GO:0042136	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042136
GO_process	GO:0042220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042220
GO_process	GO:0042416	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042416
GO_process	GO:0042420	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042420
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0045471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045471
GO_process	GO:0051583	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051583
GO_process	GO:0051591	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051591
GO_process	GO:0060134	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060134
GO_process	GO:0090494	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090494
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007568	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007568
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	SLC6A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC6A3
GeneID	6531	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6531
GeneTree	ENSGT00760000118857	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118857
HGNC	HGNC:11049	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11049
HOGENOM	HOG000116406	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116406&db=HOGENOM6
HOVERGEN	HBG071421	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG071421&db=HOVERGEN
HPA	CAB016249	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB016249
HPA	HPA013602	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA013602
InParanoid	Q01959	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q01959
IntAct	Q01959	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q01959*
InterPro	IPR000175	http://www.ebi.ac.uk/interpro/entry/IPR000175
InterPro	IPR002436	http://www.ebi.ac.uk/interpro/entry/IPR002436
Jabion	6531	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6531
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:6531	http://www.genome.jp/dbget-bin/www_bget?hsa:6531
KEGG_Orthology	KO:K05036	http://www.genome.jp/dbget-bin/www_bget?KO:K05036
KEGG_Pathway	ko04728	http://www.genome.jp/kegg-bin/show_pathway?ko04728
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05030	http://www.genome.jp/kegg-bin/show_pathway?ko05030
KEGG_Pathway	ko05031	http://www.genome.jp/kegg-bin/show_pathway?ko05031
KEGG_Pathway	ko05034	http://www.genome.jp/kegg-bin/show_pathway?ko05034
MIM	126455	http://www.ncbi.nlm.nih.gov/omim/126455
MIM	613135	http://www.ncbi.nlm.nih.gov/omim/613135
MINT	MINT-576917	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-576917
OMA	YAAYKFC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YAAYKFC
Orphanet	238455	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=238455
OrthoDB	EOG091G08PX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08PX
PANTHER	PTHR11616	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11616
PRINTS	PR00176	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00176
PRINTS	PR01202	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01202
PROSITE	PS00610	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00610
PROSITE	PS00754	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00754
PROSITE	PS50267	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50267
PSORT	swissprot:SC6A3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SC6A3_HUMAN
PSORT-B	swissprot:SC6A3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SC6A3_HUMAN
PSORT2	swissprot:SC6A3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SC6A3_HUMAN
Pfam	PF00209	http://pfam.xfam.org/family/PF00209
PharmGKB	PA311	http://www.pharmgkb.org/do/serve?objId=PA311&objCls=Gene
Phobius	swissprot:SC6A3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SC6A3_HUMAN
PhylomeDB	Q01959	http://phylomedb.org/?seqid=Q01959
ProteinModelPortal	Q01959	http://www.proteinmodelportal.org/query/uniprot/Q01959
PubMed	10391209	http://www.ncbi.nlm.nih.gov/pubmed/10391209
PubMed	10889531	http://www.ncbi.nlm.nih.gov/pubmed/10889531
PubMed	11304827	http://www.ncbi.nlm.nih.gov/pubmed/11304827
PubMed	11343649	http://www.ncbi.nlm.nih.gov/pubmed/11343649
PubMed	12177201	http://www.ncbi.nlm.nih.gov/pubmed/12177201
PubMed	1353885	http://www.ncbi.nlm.nih.gov/pubmed/1353885
PubMed	1359373	http://www.ncbi.nlm.nih.gov/pubmed/1359373
PubMed	1406597	http://www.ncbi.nlm.nih.gov/pubmed/1406597
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15505207	http://www.ncbi.nlm.nih.gov/pubmed/15505207
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	17934207	http://www.ncbi.nlm.nih.gov/pubmed/17934207
PubMed	19478460	http://www.ncbi.nlm.nih.gov/pubmed/19478460
PubMed	21179162	http://www.ncbi.nlm.nih.gov/pubmed/21179162
PubMed	7637582	http://www.ncbi.nlm.nih.gov/pubmed/7637582
PubMed	8302271	http://www.ncbi.nlm.nih.gov/pubmed/8302271
PubMed	9300814	http://www.ncbi.nlm.nih.gov/pubmed/9300814
Reactome	R-HSA-379401	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-379401
Reactome	R-HSA-442660	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442660
RefSeq	NP_001035	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001035
SMR	Q01959	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q01959
STRING	9606.ENSP00000270349	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000270349&targetmode=cogs
TCDB	2.A.22.1	http://www.tcdb.org/search/result.php?tc=2.A.22.1
UCSC	uc003jck	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003jck&org=rat
UniGene	Hs.406	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.406
UniProtKB	SC6A3_HUMAN	http://www.uniprot.org/uniprot/SC6A3_HUMAN
UniProtKB-AC	Q01959	http://www.uniprot.org/uniprot/Q01959
charge	swissprot:SC6A3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SC6A3_HUMAN
eggNOG	COG0733	http://eggnogapi.embl.de/nog_data/html/tree/COG0733
eggNOG	KOG3659	http://eggnogapi.embl.de/nog_data/html/tree/KOG3659
epestfind	swissprot:SC6A3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SC6A3_HUMAN
garnier	swissprot:SC6A3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SC6A3_HUMAN
helixturnhelix	swissprot:SC6A3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SC6A3_HUMAN
hmoment	swissprot:SC6A3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SC6A3_HUMAN
iep	swissprot:SC6A3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SC6A3_HUMAN
inforesidue	swissprot:SC6A3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SC6A3_HUMAN
neXtProt	NX_Q01959	http://www.nextprot.org/db/entry/NX_Q01959
octanol	swissprot:SC6A3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SC6A3_HUMAN
pepcoil	swissprot:SC6A3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SC6A3_HUMAN
pepdigest	swissprot:SC6A3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SC6A3_HUMAN
pepinfo	swissprot:SC6A3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SC6A3_HUMAN
pepnet	swissprot:SC6A3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SC6A3_HUMAN
pepstats	swissprot:SC6A3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SC6A3_HUMAN
pepwheel	swissprot:SC6A3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SC6A3_HUMAN
pepwindow	swissprot:SC6A3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SC6A3_HUMAN
sigcleave	swissprot:SC6A3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SC6A3_HUMAN
## Database	ID	URL or Descriptions
# AltName	S10A6_HUMAN	Calcyclin
# AltName	S10A6_HUMAN	Growth factor-inducible protein 2A9
# AltName	S10A6_HUMAN	MLN 4
# AltName	S10A6_HUMAN	Prolactin receptor-associated protein
# AltName	S10A6_HUMAN	S100 calcium-binding protein A6
# BioGrid	112185	28
# ChiTaRS	S100A6	human
# Ensembl	ENST00000368719	ENSP00000357708; ENSG00000197956
# Ensembl	ENST00000368720	ENSP00000357709; ENSG00000197956
# Ensembl	ENST00000496817	ENSP00000473589; ENSG00000197956
# ExpressionAtlas	P06703	baseline and differential
# FUNCTION	S10A6_HUMAN	May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative. {ECO 0000269|PubMed 22399290}. 
# GO_component	GO:0001726	ruffle; IDA:UniProtKB.
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005635	nuclear envelope; IDA:UniProtKB.
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005829	cytosol; IDA:UniProtKB.
# GO_component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005509	calcium ion binding; IDA:UniProtKB.
# GO_function	GO:0005523	tropomyosin binding; IDA:UniProtKB.
# GO_function	GO:0008270	zinc ion binding; IEA:Ensembl.
# GO_function	GO:0015075	ion transmembrane transporter activity; IEA:Ensembl.
# GO_function	GO:0042803	protein homodimerization activity; IDA:UniProtKB.
# GO_function	GO:0044548	S100 protein binding; IPI:UniProtKB.
# GO_function	GO:0048306	calcium-dependent protein binding; IDA:UniProtKB.
# GO_process	GO:0007165	signal transduction; TAS:UniProtKB.
# GO_process	GO:0007409	axonogenesis; NAS:UniProtKB.
# GO_process	GO:0048146	positive regulation of fibroblast proliferation; NAS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005635	nuclear envelope
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008092	cytoskeletal protein binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.10.238.10	-; 1.
# Genevisible	P06703	HS
# HGNC	HGNC:10496	S100A6
# INDUCTION	S10A6_HUMAN	Preferentially expressed when quiescent fibroblasts are stimulated to proliferate. It is inducible by growth factors and overexpressed in acute myeloid leukemias. 
# INTERACTION	S10A6_HUMAN	Q02790 FKBP4; NbExp=3; IntAct=EBI-352877, EBI-1047444; P52292 KPNA2; NbExp=3; IntAct=EBI-352877, EBI-349938; Q00987 MDM2; NbExp=2; IntAct=EBI-352877, EBI-389668; P50542 PEX5; NbExp=3; IntAct=EBI-352877, EBI-597835; P26882 PPID (xeno); NbExp=3; IntAct=EBI-352877, EBI-6477155; P04271 S100B; NbExp=5; IntAct=EBI-352877, EBI-458391; 
# IntAct	P06703	18
# InterPro	IPR001751	S100/CaBP-9k_CS
# InterPro	IPR002048	EF_hand_dom
# InterPro	IPR011992	EF-hand-dom_pair
# InterPro	IPR013787	S100_Ca-bd_sub
# InterPro	IPR018247	EF_Hand_1_Ca_BS
# MIM	114110	gene
# MISCELLANEOUS	S10A6_HUMAN	This protein co-purified with the prolactin receptor. 
# Organism	S10A6_HUMAN	Homo sapiens (Human)
# PDB	1K8U	X-ray; 1.15 A; A=1-90
# PDB	1K96	X-ray; 1.44 A; A=1-90
# PDB	1K9K	X-ray; 1.76 A; A/B=1-90
# PDB	1K9P	X-ray; 1.90 A; A=1-90
# PDB	2M1K	NMR; -; B/D=1-90
# PDB	4YBH	X-ray; 2.40 A; B=1-90
# PIR	A28363	BCHUY
# PROSITE	PS00018	EF_HAND_1
# PROSITE	PS00303	S100_CABP
# PROSITE	PS50222	EF_HAND_2
# PTM	S10A6_HUMAN	The N-terminus is blocked. 
# Pfam	PF01023	S_100
# Proteomes	UP000005640	Chromosome 1
# RecName	S10A6_HUMAN	Protein S100-A6
# RefSeq	NP_055439	NM_014624.3
# RefSeq	XP_016857522	XM_017002033.1
# SIMILARITY	Belongs to the S-100 family. {ECO	0000305}. 
# SIMILARITY	Contains 2 EF-hand domains. {ECO:0000255|PROSITE- ProRule	PRU00448}.
# SMART	SM00054	EFh
# SMART	SM01394	S_100
# SUBCELLULAR LOCATION	S10A6_HUMAN	Nucleus envelope. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. 
# SUBUNIT	S10A6_HUMAN	Homodimer; head to tail assembly of 2 subunits. Interacts with CACYBP in a calcium-dependent manner. Interacts with ANXA2 and ANXA11 (via N-terminus). Interacts with SUGT1. Interacts with TP53; has higher affinity for TP53 that is phosphorylated on its N-terminal domain, and lower affinity for TP53 that is phosphorylated on its C-terminal domain. Interacts with tropomyosin. Interacts with FKBP4. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity. {ECO 0000269|PubMed 11937060, ECO 0000269|PubMed 12746458, ECO 0000269|PubMed 19724273, ECO 0000269|PubMed 19819244, ECO 0000269|PubMed 20188096, ECO 0000269|PubMed 22399290}. 
# SUPFAM	SSF47473	SSF47473
# UCSC	uc001fbw	human
# eggNOG	ENOG410IYT5	Eukaryota
# eggNOG	ENOG410Z6I6	LUCA
BLAST	swissprot:S10A6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S10A6_HUMAN
BioCyc	ZFISH:G66-33816-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33816-MONOMER
COXPRESdb	6277	http://coxpresdb.jp/data/gene/6277.shtml
CleanEx	HS_S100A6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_S100A6
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/0006-291X(89)92166-9	http://dx.doi.org/10.1016/0006-291X(89)92166-9
DOI	10.1016/0006-291X(92)90216-8	http://dx.doi.org/10.1016/0006-291X(92)90216-8
DOI	10.1016/S0969-2126(02)00740-2	http://dx.doi.org/10.1016/S0969-2126(02)00740-2
DOI	10.1016/j.febslet.2010.02.055	http://dx.doi.org/10.1016/j.febslet.2010.02.055
DOI	10.1016/j.jmb.2009.10.002	http://dx.doi.org/10.1016/j.jmb.2009.10.002
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/sj.bjc.6605289	http://dx.doi.org/10.1038/sj.bjc.6605289
DOI	10.1074/jbc.M111.329771	http://dx.doi.org/10.1074/jbc.M111.329771
DOI	10.1074/jbc.M211518200	http://dx.doi.org/10.1074/jbc.M211518200
DOI	10.1074/jbc.M212669200	http://dx.doi.org/10.1074/jbc.M212669200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AY034480	http://www.ebi.ac.uk/ena/data/view/AY034480
EMBL	BC001431	http://www.ebi.ac.uk/ena/data/view/BC001431
EMBL	BC009017	http://www.ebi.ac.uk/ena/data/view/BC009017
EMBL	BT006965	http://www.ebi.ac.uk/ena/data/view/BT006965
EMBL	BX470102	http://www.ebi.ac.uk/ena/data/view/BX470102
EMBL	CH471121	http://www.ebi.ac.uk/ena/data/view/CH471121
EMBL	CH471121	http://www.ebi.ac.uk/ena/data/view/CH471121
EMBL	CH471121	http://www.ebi.ac.uk/ena/data/view/CH471121
EMBL	CH471121	http://www.ebi.ac.uk/ena/data/view/CH471121
EMBL	CH471121	http://www.ebi.ac.uk/ena/data/view/CH471121
EMBL	CH471121	http://www.ebi.ac.uk/ena/data/view/CH471121
EMBL	CH471121	http://www.ebi.ac.uk/ena/data/view/CH471121
EMBL	CH471121	http://www.ebi.ac.uk/ena/data/view/CH471121
EMBL	J02763	http://www.ebi.ac.uk/ena/data/view/J02763
EMBL	M14300	http://www.ebi.ac.uk/ena/data/view/M14300
EMBL	M18981	http://www.ebi.ac.uk/ena/data/view/M18981
Ensembl	ENST00000368719	http://www.ensembl.org/id/ENST00000368719
Ensembl	ENST00000368720	http://www.ensembl.org/id/ENST00000368720
Ensembl	ENST00000496817	http://www.ensembl.org/id/ENST00000496817
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0001726	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001726
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0031234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031234
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0005523	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005523
GO_function	GO:0008270	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270
GO_function	GO:0015075	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015075
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_function	GO:0044548	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044548
GO_function	GO:0048306	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048306
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007409	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007409
GO_process	GO:0048146	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048146
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.10.238.10	http://www.cathdb.info/version/latest/superfamily/1.10.238.10
GeneCards	S100A6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=S100A6
GeneID	6277	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6277
GeneTree	ENSGT00760000119034	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119034
HGNC	HGNC:10496	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10496
HOGENOM	HOG000246968	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000246968&db=HOGENOM6
HOVERGEN	HBG001479	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG001479&db=HOVERGEN
HPA	CAB002601	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB002601
HPA	CAB040549	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB040549
HPA	HPA007575	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA007575
InParanoid	P06703	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06703
IntAct	P06703	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06703*
InterPro	IPR001751	http://www.ebi.ac.uk/interpro/entry/IPR001751
InterPro	IPR002048	http://www.ebi.ac.uk/interpro/entry/IPR002048
InterPro	IPR011992	http://www.ebi.ac.uk/interpro/entry/IPR011992
InterPro	IPR013787	http://www.ebi.ac.uk/interpro/entry/IPR013787
InterPro	IPR018247	http://www.ebi.ac.uk/interpro/entry/IPR018247
Jabion	6277	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6277
KEGG_Gene	hsa:6277	http://www.genome.jp/dbget-bin/www_bget?hsa:6277
MIM	114110	http://www.ncbi.nlm.nih.gov/omim/114110
MINT	MINT-3005220	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3005220
OMA	QVVNFQE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QVVNFQE
OrthoDB	EOG091G10JX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G10JX
PDB	1K8U	http://www.ebi.ac.uk/pdbe-srv/view/entry/1K8U
PDB	1K96	http://www.ebi.ac.uk/pdbe-srv/view/entry/1K96
PDB	1K9K	http://www.ebi.ac.uk/pdbe-srv/view/entry/1K9K
PDB	1K9P	http://www.ebi.ac.uk/pdbe-srv/view/entry/1K9P
PDB	2M1K	http://www.ebi.ac.uk/pdbe-srv/view/entry/2M1K
PDB	4YBH	http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBH
PDBsum	1K8U	http://www.ebi.ac.uk/pdbsum/1K8U
PDBsum	1K96	http://www.ebi.ac.uk/pdbsum/1K96
PDBsum	1K9K	http://www.ebi.ac.uk/pdbsum/1K9K
PDBsum	1K9P	http://www.ebi.ac.uk/pdbsum/1K9P
PDBsum	2M1K	http://www.ebi.ac.uk/pdbsum/2M1K
PDBsum	4YBH	http://www.ebi.ac.uk/pdbsum/4YBH
PROSITE	PS00018	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00018
PROSITE	PS00303	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00303
PROSITE	PS50222	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50222
PSORT	swissprot:S10A6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S10A6_HUMAN
PSORT-B	swissprot:S10A6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S10A6_HUMAN
PSORT2	swissprot:S10A6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S10A6_HUMAN
Pfam	PF01023	http://pfam.xfam.org/family/PF01023
PharmGKB	PA34908	http://www.pharmgkb.org/do/serve?objId=PA34908&objCls=Gene
Phobius	swissprot:S10A6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S10A6_HUMAN
PhylomeDB	P06703	http://phylomedb.org/?seqid=P06703
ProteinModelPortal	P06703	http://www.proteinmodelportal.org/query/uniprot/P06703
PubMed	11937060	http://www.ncbi.nlm.nih.gov/pubmed/11937060
PubMed	12601007	http://www.ncbi.nlm.nih.gov/pubmed/12601007
PubMed	12746458	http://www.ncbi.nlm.nih.gov/pubmed/12746458
PubMed	1482346	http://www.ncbi.nlm.nih.gov/pubmed/1482346
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	19724273	http://www.ncbi.nlm.nih.gov/pubmed/19724273
PubMed	19819244	http://www.ncbi.nlm.nih.gov/pubmed/19819244
PubMed	20188096	http://www.ncbi.nlm.nih.gov/pubmed/20188096
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22399290	http://www.ncbi.nlm.nih.gov/pubmed/22399290
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	2448309	http://www.ncbi.nlm.nih.gov/pubmed/2448309
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	2775283	http://www.ncbi.nlm.nih.gov/pubmed/2775283
PubMed	3036810	http://www.ncbi.nlm.nih.gov/pubmed/3036810
PubMed	3755724	http://www.ncbi.nlm.nih.gov/pubmed/3755724
RefSeq	NP_055439	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055439
RefSeq	XP_016857522	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016857522
SMART	SM00054	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00054
SMART	SM01394	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01394
SMR	P06703	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06703
STRING	9606.ENSP00000357708	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000357708&targetmode=cogs
SUPFAM	SSF47473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47473
UCSC	uc001fbw	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001fbw&org=rat
UniGene	Hs.275243	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.275243
UniProtKB	S10A6_HUMAN	http://www.uniprot.org/uniprot/S10A6_HUMAN
UniProtKB-AC	P06703	http://www.uniprot.org/uniprot/P06703
charge	swissprot:S10A6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S10A6_HUMAN
eggNOG	ENOG410IYT5	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IYT5
eggNOG	ENOG410Z6I6	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z6I6
epestfind	swissprot:S10A6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S10A6_HUMAN
garnier	swissprot:S10A6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S10A6_HUMAN
helixturnhelix	swissprot:S10A6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S10A6_HUMAN
hmoment	swissprot:S10A6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S10A6_HUMAN
iep	swissprot:S10A6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S10A6_HUMAN
inforesidue	swissprot:S10A6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S10A6_HUMAN
neXtProt	NX_P06703	http://www.nextprot.org/db/entry/NX_P06703
octanol	swissprot:S10A6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S10A6_HUMAN
pepcoil	swissprot:S10A6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S10A6_HUMAN
pepdigest	swissprot:S10A6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S10A6_HUMAN
pepinfo	swissprot:S10A6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S10A6_HUMAN
pepnet	swissprot:S10A6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S10A6_HUMAN
pepstats	swissprot:S10A6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S10A6_HUMAN
pepwheel	swissprot:S10A6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S10A6_HUMAN
pepwindow	swissprot:S10A6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S10A6_HUMAN
sigcleave	swissprot:S10A6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S10A6_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GBRB1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P18505-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=P18505-2; Sequence=VSP_055900, VSP_055901; 
# AltName	GBRB1_HUMAN	GABA(A) receptor subunit beta-1
# BioGrid	108834	5
# CCDS	CCDS3474	-. [P18505-1]
# DrugBank	DB00186	Lorazepam
# DrugBank	DB00189	Ethchlorvynol
# DrugBank	DB00228	Enflurane
# DrugBank	DB00231	Temazepam
# DrugBank	DB00237	Butabarbital
# DrugBank	DB00241	Butalbital
# DrugBank	DB00273	Topiramate
# DrugBank	DB00292	Etomidate
# DrugBank	DB00306	Talbutal
# DrugBank	DB00312	Pentobarbital
# DrugBank	DB00334	Olanzapine
# DrugBank	DB00349	Clobazam
# DrugBank	DB00371	Meprobamate
# DrugBank	DB00402	Eszopiclone
# DrugBank	DB00404	Alprazolam
# DrugBank	DB00431	Lindane
# DrugBank	DB00475	Chlordiazepoxide
# DrugBank	DB00543	Amoxapine
# DrugBank	DB00546	Adinazolam
# DrugBank	DB00628	Clorazepate
# DrugBank	DB00659	Acamprosate
# DrugBank	DB00683	Midazolam
# DrugBank	DB00690	Flurazepam
# DrugBank	DB00753	Isoflurane
# DrugBank	DB00794	Primidone
# DrugBank	DB00801	Halazepam
# DrugBank	DB00818	Propofol
# DrugBank	DB00829	Diazepam
# DrugBank	DB00842	Oxazepam
# DrugBank	DB00897	Triazolam
# DrugBank	DB00898	Ethanol
# DrugBank	DB01028	Methoxyflurane
# DrugBank	DB01049	Ergoloid mesylate
# DrugBank	DB01068	Clonazepam
# DrugBank	DB01107	Methyprylon
# DrugBank	DB01159	Halothane
# DrugBank	DB01189	Desflurane
# DrugBank	DB01205	Flumazenil
# DrugBank	DB01215	Estazolam
# DrugBank	DB01236	Sevoflurane
# DrugBank	DB01437	Glutethimide
# DrugBank	DB01440	Gamma Hydroxybutyric Acid
# DrugBank	DB01558	Bromazepam
# DrugBank	DB01559	Clotiazepam
# DrugBank	DB01567	Fludiazepam
# DrugBank	DB01587	Ketazolam
# DrugBank	DB01588	Prazepam
# DrugBank	DB01589	Quazepam
# DrugBank	DB01594	Cinolazepam
# DrugBank	DB01595	Nitrazepam
# Ensembl	ENST00000295454	ENSP00000295454; ENSG00000163288. [P18505-1]
# Ensembl	ENST00000510909	ENSP00000426766; ENSG00000163288. [P18505-2]
# ExpressionAtlas	P18505	baseline and differential
# FUNCTION	GBRB1_HUMAN	Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel (By similarity). {ECO 0000250}. 
# GO_component	GO:0005635	nuclear envelope; IEA:Ensembl.
# GO_component	GO:0005737	cytoplasm; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; ISS:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030425	dendrite; IEA:Ensembl.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:1902711	GABA-A receptor complex; ISS:UniProtKB.
# GO_function	GO:0004890	GABA-A receptor activity; ISS:UniProtKB.
# GO_function	GO:0015276	ligand-gated ion channel activity; ISS:UniProtKB.
# GO_function	GO:0022851	GABA-gated chloride ion channel activity; IDA:GO_Central.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006811	ion transport; ISS:UniProtKB.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0009636	response to toxic substance; IEA:Ensembl.
# GO_process	GO:0021954	central nervous system neuron development; IEA:Ensembl.
# GO_process	GO:0032570	response to progesterone; IEA:Ensembl.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0042698	ovulation cycle; IEA:Ensembl.
# GO_process	GO:0071420	cellular response to histamine; ISS:UniProtKB.
# GO_process	GO:1902476	chloride transmembrane transport; IDA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005635	nuclear envelope
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.70.170.10	-; 1.
# Genevisible	P18505	HS
# HGNC	HGNC:4081	GABRB1
# IntAct	P18505	4
# InterPro	IPR002289	GABAAb_rcpt
# InterPro	IPR006028	GABAA/Glycine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04726	Serotonergic synapse
# KEGG_Pathway	ko04727	GABAergic synapse
# KEGG_Pathway	ko05032	Morphine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# MIM	137190	gene
# Organism	GBRB1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR18945	PTHR18945; 2
# PIR	A40336	A40336
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00253	GABAARECEPTR
# PRINTS	PR01160	GABAARBETA
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-112314	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
# Reactome	R-HSA-975298	Ligand-gated ion channel transport
# Reactome	R-HSA-977441	GABA A receptor activation
# RecName	GBRB1_HUMAN	Gamma-aminobutyric acid receptor subunit beta-1
# RefSeq	NP_000803	NM_000812.3. [P18505-1]
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB1 sub-subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	GBRB1_HUMAN	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Binds UBQLN1 (By similarity). Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains. Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents (By similarity). {ECO	0000250}. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TIGRFAMs	TIGR00860	LIC
# UCSC	uc062wjg	human. [P18505-1]
# WEB RESOURCE	GBRB1_HUMAN	Name=Protein Spotlight; Note=Forbidden fruit - Issue 56 of March 2005; URL="http //web.expasy.org/spotlight/back_issues/056";
# eggNOG	ENOG410XPWH	LUCA
# eggNOG	KOG3643	Eukaryota
BLAST	swissprot:GBRB1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GBRB1_HUMAN
COXPRESdb	2560	http://coxpresdb.jp/data/gene/2560.shtml
CleanEx	HS_GABRB1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GABRB1
DOI	10.1002/ajmg.1320540105	http://dx.doi.org/10.1002/ajmg.1320540105
DOI	10.1016/0014-5793(89)80563-0	http://dx.doi.org/10.1016/0014-5793(89)80563-0
DOI	10.1016/0888-7543(91)90189-L	http://dx.doi.org/10.1016/0888-7543(91)90189-L
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ncomms4650	http://dx.doi.org/10.1038/ncomms4650
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00186	http://www.drugbank.ca/drugs/DB00186
DrugBank	DB00189	http://www.drugbank.ca/drugs/DB00189
DrugBank	DB00228	http://www.drugbank.ca/drugs/DB00228
DrugBank	DB00231	http://www.drugbank.ca/drugs/DB00231
DrugBank	DB00237	http://www.drugbank.ca/drugs/DB00237
DrugBank	DB00241	http://www.drugbank.ca/drugs/DB00241
DrugBank	DB00273	http://www.drugbank.ca/drugs/DB00273
DrugBank	DB00292	http://www.drugbank.ca/drugs/DB00292
DrugBank	DB00306	http://www.drugbank.ca/drugs/DB00306
DrugBank	DB00312	http://www.drugbank.ca/drugs/DB00312
DrugBank	DB00334	http://www.drugbank.ca/drugs/DB00334
DrugBank	DB00349	http://www.drugbank.ca/drugs/DB00349
DrugBank	DB00371	http://www.drugbank.ca/drugs/DB00371
DrugBank	DB00402	http://www.drugbank.ca/drugs/DB00402
DrugBank	DB00404	http://www.drugbank.ca/drugs/DB00404
DrugBank	DB00431	http://www.drugbank.ca/drugs/DB00431
DrugBank	DB00475	http://www.drugbank.ca/drugs/DB00475
DrugBank	DB00543	http://www.drugbank.ca/drugs/DB00543
DrugBank	DB00546	http://www.drugbank.ca/drugs/DB00546
DrugBank	DB00628	http://www.drugbank.ca/drugs/DB00628
DrugBank	DB00659	http://www.drugbank.ca/drugs/DB00659
DrugBank	DB00683	http://www.drugbank.ca/drugs/DB00683
DrugBank	DB00690	http://www.drugbank.ca/drugs/DB00690
DrugBank	DB00753	http://www.drugbank.ca/drugs/DB00753
DrugBank	DB00794	http://www.drugbank.ca/drugs/DB00794
DrugBank	DB00801	http://www.drugbank.ca/drugs/DB00801
DrugBank	DB00818	http://www.drugbank.ca/drugs/DB00818
DrugBank	DB00829	http://www.drugbank.ca/drugs/DB00829
DrugBank	DB00842	http://www.drugbank.ca/drugs/DB00842
DrugBank	DB00897	http://www.drugbank.ca/drugs/DB00897
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01028	http://www.drugbank.ca/drugs/DB01028
DrugBank	DB01049	http://www.drugbank.ca/drugs/DB01049
DrugBank	DB01068	http://www.drugbank.ca/drugs/DB01068
DrugBank	DB01107	http://www.drugbank.ca/drugs/DB01107
DrugBank	DB01159	http://www.drugbank.ca/drugs/DB01159
DrugBank	DB01189	http://www.drugbank.ca/drugs/DB01189
DrugBank	DB01205	http://www.drugbank.ca/drugs/DB01205
DrugBank	DB01215	http://www.drugbank.ca/drugs/DB01215
DrugBank	DB01236	http://www.drugbank.ca/drugs/DB01236
DrugBank	DB01437	http://www.drugbank.ca/drugs/DB01437
DrugBank	DB01440	http://www.drugbank.ca/drugs/DB01440
DrugBank	DB01558	http://www.drugbank.ca/drugs/DB01558
DrugBank	DB01559	http://www.drugbank.ca/drugs/DB01559
DrugBank	DB01567	http://www.drugbank.ca/drugs/DB01567
DrugBank	DB01587	http://www.drugbank.ca/drugs/DB01587
DrugBank	DB01588	http://www.drugbank.ca/drugs/DB01588
DrugBank	DB01589	http://www.drugbank.ca/drugs/DB01589
DrugBank	DB01594	http://www.drugbank.ca/drugs/DB01594
DrugBank	DB01595	http://www.drugbank.ca/drugs/DB01595
EMBL	AC097712	http://www.ebi.ac.uk/ena/data/view/AC097712
EMBL	AC105394	http://www.ebi.ac.uk/ena/data/view/AC105394
EMBL	AC107383	http://www.ebi.ac.uk/ena/data/view/AC107383
EMBL	AC107392	http://www.ebi.ac.uk/ena/data/view/AC107392
EMBL	AK312720	http://www.ebi.ac.uk/ena/data/view/AK312720
EMBL	BC022449	http://www.ebi.ac.uk/ena/data/view/BC022449
EMBL	CH471069	http://www.ebi.ac.uk/ena/data/view/CH471069
EMBL	KJ535054	http://www.ebi.ac.uk/ena/data/view/KJ535054
EMBL	M59212	http://www.ebi.ac.uk/ena/data/view/M59212
EMBL	M59214	http://www.ebi.ac.uk/ena/data/view/M59214
EMBL	M59215	http://www.ebi.ac.uk/ena/data/view/M59215
EMBL	M59216	http://www.ebi.ac.uk/ena/data/view/M59216
EMBL	S70733	http://www.ebi.ac.uk/ena/data/view/S70733
EMBL	X14767	http://www.ebi.ac.uk/ena/data/view/X14767
Ensembl	ENST00000295454	http://www.ensembl.org/id/ENST00000295454
Ensembl	ENST00000510909	http://www.ensembl.org/id/ENST00000510909
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_component	GO:1902711	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902711
GO_function	GO:0004890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004890
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_function	GO:0022851	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022851
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0009636	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009636
GO_process	GO:0021954	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021954
GO_process	GO:0032570	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032570
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0042698	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042698
GO_process	GO:0071420	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071420
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	GABRB1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GABRB1
GeneID	2560	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2560
GeneTree	ENSGT00760000118821	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118821
H-InvDB	HIX0004191	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0004191
H-InvDB	HIX0164000	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0164000
HGNC	HGNC:4081	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4081
HOGENOM	HOG000231335	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231335&db=HOGENOM6
HOVERGEN	HBG051707	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051707&db=HOVERGEN
HPA	HPA051297	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA051297
InParanoid	P18505	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P18505
IntAct	P18505	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P18505*
InterPro	IPR002289	http://www.ebi.ac.uk/interpro/entry/IPR002289
InterPro	IPR006028	http://www.ebi.ac.uk/interpro/entry/IPR006028
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
Jabion	2560	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2560
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:2560	http://www.genome.jp/dbget-bin/www_bget?hsa:2560
KEGG_Orthology	KO:K05181	http://www.genome.jp/dbget-bin/www_bget?KO:K05181
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04726	http://www.genome.jp/kegg-bin/show_pathway?ko04726
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
KEGG_Pathway	ko05032	http://www.genome.jp/kegg-bin/show_pathway?ko05032
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
MIM	137190	http://www.ncbi.nlm.nih.gov/omim/137190
OMA	CAHSSNE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CAHSSNE
OrthoDB	EOG091G0805	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0805
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00253	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00253
PRINTS	PR01160	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01160
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:GBRB1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GBRB1_HUMAN
PSORT-B	swissprot:GBRB1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GBRB1_HUMAN
PSORT2	swissprot:GBRB1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GBRB1_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA28495	http://www.pharmgkb.org/do/serve?objId=PA28495&objCls=Gene
Phobius	swissprot:GBRB1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GBRB1_HUMAN
PhylomeDB	P18505	http://phylomedb.org/?seqid=P18505
ProteinModelPortal	P18505	http://www.proteinmodelportal.org/query/uniprot/P18505
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	1655634	http://www.ncbi.nlm.nih.gov/pubmed/1655634
PubMed	2160058	http://www.ncbi.nlm.nih.gov/pubmed/2160058
PubMed	2465923	http://www.ncbi.nlm.nih.gov/pubmed/2465923
PubMed	24722188	http://www.ncbi.nlm.nih.gov/pubmed/24722188
PubMed	8178835	http://www.ncbi.nlm.nih.gov/pubmed/8178835
Reactome	R-HSA-112314	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112314
Reactome	R-HSA-975298	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-975298
Reactome	R-HSA-977441	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-977441
RefSeq	NP_000803	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000803
SMR	P18505	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P18505
STRING	9606.ENSP00000295454	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000295454&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc062wjg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc062wjg&org=rat
UniGene	Hs.254117	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.254117
UniGene	Hs.27283	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.27283
UniGene	Hs.633316	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.633316
UniProtKB	GBRB1_HUMAN	http://www.uniprot.org/uniprot/GBRB1_HUMAN
UniProtKB-AC	P18505	http://www.uniprot.org/uniprot/P18505
charge	swissprot:GBRB1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GBRB1_HUMAN
eggNOG	ENOG410XPWH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPWH
eggNOG	KOG3643	http://eggnogapi.embl.de/nog_data/html/tree/KOG3643
epestfind	swissprot:GBRB1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GBRB1_HUMAN
garnier	swissprot:GBRB1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GBRB1_HUMAN
helixturnhelix	swissprot:GBRB1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GBRB1_HUMAN
hmoment	swissprot:GBRB1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GBRB1_HUMAN
iep	swissprot:GBRB1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GBRB1_HUMAN
inforesidue	swissprot:GBRB1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GBRB1_HUMAN
neXtProt	NX_P18505	http://www.nextprot.org/db/entry/NX_P18505
octanol	swissprot:GBRB1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GBRB1_HUMAN
pepcoil	swissprot:GBRB1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GBRB1_HUMAN
pepdigest	swissprot:GBRB1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GBRB1_HUMAN
pepinfo	swissprot:GBRB1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GBRB1_HUMAN
pepnet	swissprot:GBRB1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GBRB1_HUMAN
pepstats	swissprot:GBRB1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GBRB1_HUMAN
pepwheel	swissprot:GBRB1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GBRB1_HUMAN
pepwindow	swissprot:GBRB1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GBRB1_HUMAN
sigcleave	swissprot:GBRB1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GBRB1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ABCAA_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8WWZ4-1; Sequence=Displayed; Name=2; Synonyms=ABCA10delta+82; IsoId=Q8WWZ4-2; Sequence=VSP_021061; Name=3; Synonyms=ABCA10delta-104; IsoId=Q8WWZ4-3; Sequence=VSP_021062, VSP_021063; Name=4; Synonyms=ABCA10delta-176; IsoId=Q8WWZ4-4; Sequence=VSP_021065, VSP_021066; Name=5; IsoId=Q8WWZ4-5; Sequence=VSP_021064, VSP_021067; Note=No experimental confirmation available.; 
# BioGrid	115630	2
# CCDS	CCDS11684	-. [Q8WWZ4-1]
# ChiTaRS	ABCA10	human
# Ensembl	ENST00000269081	ENSP00000269081; ENSG00000154263. [Q8WWZ4-1]
# Ensembl	ENST00000522406	ENSP00000429853; ENSG00000154263. [Q8WWZ4-5]
# Ensembl	ENST00000523512	ENSP00000429945; ENSG00000154263. [Q8WWZ4-3]
# ExpressionAtlas	Q8WWZ4	baseline and differential
# FUNCTION	ABCAA_HUMAN	Probable transporter which may play a role in macrophage lipid homeostasis. 
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IBA:GO_Central.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; IBA:GO_Central.
# GO_process	GO:0006869	lipid transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# Gene3D	3.40.50.300	-; 2.
# HGNC	HGNC:30	ABCA10
# INDUCTION	Down-regulated by cholesterol loading of macrophages. {ECO:0000269|PubMed	12821155}. 
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR026082	ABC_A
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko02010	ABC transporters
# MIM	612508	gene
# Organism	ABCAA_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR19229	PTHR19229
# PROSITE	PS00211	ABC_TRANSPORTER_1
# PROSITE	PS50893	ABC_TRANSPORTER_2; 2
# Pfam	PF00005	ABC_tran; 2
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-1369062	ABC transporters in lipid homeostasis
# RecName	ABCAA_HUMAN	ATP-binding cassette sub-family A member 10
# RefSeq	NP_525021	NM_080282.3. [Q8WWZ4-1]
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCA family. {ECO	0000305}. 
# SIMILARITY	Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA; 2
# SUBCELLULAR LOCATION	ABCAA_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF52540	SSF52540; 2
# TCDB	3.A.1.211.17	the atp-binding cassette (abc) superfamily
# TISSUE SPECIFICITY	Widely expressed. Highly expressed in skeletal muscle, heart, brain and gastrointestinal tract. {ECO:0000269|PubMed	12821155, ECO:0000269|Ref.1}. 
# UCSC	uc010dfa	human. [Q8WWZ4-1]
# WEB RESOURCE	ABCAA_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=Q8WWZ4";
# eggNOG	COG1131	LUCA
# eggNOG	KOG0059	Eukaryota
BLAST	swissprot:ABCAA_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCAA_HUMAN
BioCyc	ZFISH:ENSG00000154263-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000154263-MONOMER
COXPRESdb	10349	http://coxpresdb.jp/data/gene/10349.shtml
CleanEx	HS_ABCA10	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCA10
DOI	10.1016/S0006-291X(03)01097-0	http://dx.doi.org/10.1016/S0006-291X(03)01097-0
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AC005495	http://www.ebi.ac.uk/ena/data/view/AC005495
EMBL	AL832004	http://www.ebi.ac.uk/ena/data/view/AL832004
EMBL	AY028900	http://www.ebi.ac.uk/ena/data/view/AY028900
EMBL	AY247065	http://www.ebi.ac.uk/ena/data/view/AY247065
EMBL	AY247069	http://www.ebi.ac.uk/ena/data/view/AY247069
EMBL	AY247070	http://www.ebi.ac.uk/ena/data/view/AY247070
EMBL	AY247071	http://www.ebi.ac.uk/ena/data/view/AY247071
EMBL	AY247072	http://www.ebi.ac.uk/ena/data/view/AY247072
EMBL	AY247073	http://www.ebi.ac.uk/ena/data/view/AY247073
EMBL	AY247074	http://www.ebi.ac.uk/ena/data/view/AY247074
EMBL	AY247075	http://www.ebi.ac.uk/ena/data/view/AY247075
EMBL	AY247076	http://www.ebi.ac.uk/ena/data/view/AY247076
EMBL	AY247077	http://www.ebi.ac.uk/ena/data/view/AY247077
EMBL	AY247078	http://www.ebi.ac.uk/ena/data/view/AY247078
EMBL	AY247079	http://www.ebi.ac.uk/ena/data/view/AY247079
EMBL	AY247080	http://www.ebi.ac.uk/ena/data/view/AY247080
EMBL	AY247081	http://www.ebi.ac.uk/ena/data/view/AY247081
EMBL	AY247082	http://www.ebi.ac.uk/ena/data/view/AY247082
EMBL	AY247083	http://www.ebi.ac.uk/ena/data/view/AY247083
EMBL	AY247084	http://www.ebi.ac.uk/ena/data/view/AY247084
EMBL	AY247085	http://www.ebi.ac.uk/ena/data/view/AY247085
EMBL	AY247086	http://www.ebi.ac.uk/ena/data/view/AY247086
EMBL	AY247087	http://www.ebi.ac.uk/ena/data/view/AY247087
EMBL	AY247088	http://www.ebi.ac.uk/ena/data/view/AY247088
EMBL	AY247089	http://www.ebi.ac.uk/ena/data/view/AY247089
EMBL	AY247090	http://www.ebi.ac.uk/ena/data/view/AY247090
EMBL	AY247091	http://www.ebi.ac.uk/ena/data/view/AY247091
EMBL	AY247092	http://www.ebi.ac.uk/ena/data/view/AY247092
EMBL	AY247093	http://www.ebi.ac.uk/ena/data/view/AY247093
EMBL	AY247094	http://www.ebi.ac.uk/ena/data/view/AY247094
EMBL	AY247095	http://www.ebi.ac.uk/ena/data/view/AY247095
EMBL	AY247096	http://www.ebi.ac.uk/ena/data/view/AY247096
EMBL	AY247097	http://www.ebi.ac.uk/ena/data/view/AY247097
EMBL	AY247098	http://www.ebi.ac.uk/ena/data/view/AY247098
EMBL	AY247099	http://www.ebi.ac.uk/ena/data/view/AY247099
EMBL	AY247100	http://www.ebi.ac.uk/ena/data/view/AY247100
EMBL	AY247101	http://www.ebi.ac.uk/ena/data/view/AY247101
EMBL	AY247102	http://www.ebi.ac.uk/ena/data/view/AY247102
EMBL	AY247103	http://www.ebi.ac.uk/ena/data/view/AY247103
EMBL	AY247104	http://www.ebi.ac.uk/ena/data/view/AY247104
EMBL	AY247105	http://www.ebi.ac.uk/ena/data/view/AY247105
EMBL	BC031026	http://www.ebi.ac.uk/ena/data/view/BC031026
EMBL	BC051320	http://www.ebi.ac.uk/ena/data/view/BC051320
Ensembl	ENST00000269081	http://www.ensembl.org/id/ENST00000269081
Ensembl	ENST00000522406	http://www.ensembl.org/id/ENST00000522406
Ensembl	ENST00000523512	http://www.ensembl.org/id/ENST00000523512
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GO_process	GO:0006869	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006869
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCA10	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCA10
GeneID	10349	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10349
GeneTree	ENSGT00760000118965	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118965
HGNC	HGNC:30	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:30
HOVERGEN	HBG079884	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG079884&db=HOVERGEN
HPA	HPA014535	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014535
InParanoid	Q8WWZ4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8WWZ4
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR026082	http://www.ebi.ac.uk/interpro/entry/IPR026082
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	10349	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10349
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:10349	http://www.genome.jp/dbget-bin/www_bget?hsa:10349
KEGG_Orthology	KO:K05652	http://www.genome.jp/dbget-bin/www_bget?KO:K05652
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
MIM	612508	http://www.ncbi.nlm.nih.gov/omim/612508
OMA	EWFIFIC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EWFIFIC
OrthoDB	EOG091G00AG	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00AG
PANTHER	PTHR19229	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19229
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PSORT	swissprot:ABCAA_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCAA_HUMAN
PSORT-B	swissprot:ABCAA_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCAA_HUMAN
PSORT2	swissprot:ABCAA_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCAA_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
PharmGKB	PA24374	http://www.pharmgkb.org/do/serve?objId=PA24374&objCls=Gene
Phobius	swissprot:ABCAA_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCAA_HUMAN
PhylomeDB	Q8WWZ4	http://phylomedb.org/?seqid=Q8WWZ4
ProteinModelPortal	Q8WWZ4	http://www.proteinmodelportal.org/query/uniprot/Q8WWZ4
PubMed	12821155	http://www.ncbi.nlm.nih.gov/pubmed/12821155
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
Reactome	R-HSA-1369062	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1369062
RefSeq	NP_525021	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_525021
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	Q8WWZ4	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8WWZ4
STRING	9606.ENSP00000269081	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000269081&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TCDB	3.A.1.211.17	http://www.tcdb.org/search/result.php?tc=3.A.1.211.17
UCSC	uc010dfa	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010dfa&org=rat
UniGene	Hs.25377	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.25377
UniProtKB	ABCAA_HUMAN	http://www.uniprot.org/uniprot/ABCAA_HUMAN
UniProtKB-AC	Q8WWZ4	http://www.uniprot.org/uniprot/Q8WWZ4
charge	swissprot:ABCAA_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCAA_HUMAN
eggNOG	COG1131	http://eggnogapi.embl.de/nog_data/html/tree/COG1131
eggNOG	KOG0059	http://eggnogapi.embl.de/nog_data/html/tree/KOG0059
epestfind	swissprot:ABCAA_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCAA_HUMAN
garnier	swissprot:ABCAA_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCAA_HUMAN
helixturnhelix	swissprot:ABCAA_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCAA_HUMAN
hmoment	swissprot:ABCAA_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCAA_HUMAN
iep	swissprot:ABCAA_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCAA_HUMAN
inforesidue	swissprot:ABCAA_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCAA_HUMAN
neXtProt	NX_Q8WWZ4	http://www.nextprot.org/db/entry/NX_Q8WWZ4
octanol	swissprot:ABCAA_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCAA_HUMAN
pepcoil	swissprot:ABCAA_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCAA_HUMAN
pepdigest	swissprot:ABCAA_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCAA_HUMAN
pepinfo	swissprot:ABCAA_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCAA_HUMAN
pepnet	swissprot:ABCAA_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCAA_HUMAN
pepstats	swissprot:ABCAA_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCAA_HUMAN
pepwheel	swissprot:ABCAA_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCAA_HUMAN
pepwindow	swissprot:ABCAA_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCAA_HUMAN
sigcleave	swissprot:ABCAA_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCAA_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	114489	9
# DOMAIN	CLIC3_HUMAN	Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity). {ECO 0000250}. 
# Ensembl	ENST00000494426	ENSP00000419378; ENSG00000169583
# FUNCTION	CLIC3_HUMAN	Can insert into membranes and form chloride ion channels. May participate in cellular growth control. {ECO 0000269|PubMed 9880541}. 
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005244	voltage-gated ion channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0005254	chloride channel activity; IMP:UniProtKB.
# GO_process	GO:0006821	chloride transport; IMP:UniProtKB.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# Gene3D	1.20.1050.10	-; 1.
# Gene3D	3.40.30.10	-; 1.
# Genevisible	O95833	HS
# HGNC	HGNC:2064	CLIC3
# INTERACTION	CLIC3_HUMAN	Q5JST6 EFHC2; NbExp=3; IntAct=EBI-10192241, EBI-2349927; Q9NUX5 POT1; NbExp=2; IntAct=EBI-10192241, EBI-752420; 
# IntAct	O95833	3
# InterPro	IPR002946	CLIC
# InterPro	IPR004045	Glutathione_S-Trfase_N
# InterPro	IPR010987	Glutathione-S-Trfase_C-like
# InterPro	IPR012336	Thioredoxin-like_fold
# InterPro	IPR030261	CLIC-3
# KEGG_Brite	ko04040	Ion channels
# MIM	606533	gene
# Organism	CLIC3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11260:SF266	PTHR11260:SF266; 2
# PDB	3FY7	X-ray; 1.95 A; A/B=1-230
# PDB	3KJY	X-ray; 1.95 A; A/B=1-230
# PRINTS	PR01263	INTCLCHANNEL
# PROSITE	PS50404	GST_NTER
# PROSITE	PS50405	GST_CTER
# Pfam	PF13417	GST_N_3
# Proteomes	UP000005640	Chromosome 9
# RecName	CLIC3_HUMAN	Chloride intracellular channel protein 3
# RefSeq	NP_004660	NM_004669.2
# RefSeq	XP_016870771	XM_017015282.1
# SEQUENCE CAUTION	Sequence=AAD16450.1; Type=Frameshift; Positions=28; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the chloride channel CLIC family. {ECO	0000305}. 
# SIMILARITY	Contains 1 GST C-terminal domain. {ECO	0000305}. 
# SIMILARITY	Contains 1 GST N-terminal domain. {ECO	0000305}. 
# SUBCELLULAR LOCATION	CLIC3_HUMAN	Nucleus. Membrane; Single-pass membrane protein. Cytoplasm. Note=Predominantly nuclear. Some protein was found in the cytoplasm. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity). {ECO 0000250}. 
# SUBUNIT	CLIC3_HUMAN	Associated with the C-terminal of ERK7. 
# SUPFAM	SSF47616	SSF47616
# SUPFAM	SSF52833	SSF52833
# TCDB	1.A.12.1	the intracellular chloride channel (clic) family
# TISSUE SPECIFICITY	CLIC3_HUMAN	Detected in placenta (at protein level). Widely expressed. High expression is found in placenta followed by lung and heart. Low expression in skeletal muscle, kidney and pancreas. {ECO 0000269|PubMed 17027078, ECO 0000269|PubMed 9880541}. 
# UCSC	uc004ckj	human
# eggNOG	ENOG410INGX	Eukaryota
# eggNOG	ENOG41128FW	LUCA
BLAST	swissprot:CLIC3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CLIC3_HUMAN
BioCyc	ZFISH:ENSG00000169583-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000169583-MONOMER
COXPRESdb	9022	http://coxpresdb.jp/data/gene/9022.shtml
CleanEx	HS_CLIC3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CLIC3
DOI	10.1002/prot.22675	http://dx.doi.org/10.1002/prot.22675
DOI	10.1016/j.placenta.2006.08.002	http://dx.doi.org/10.1016/j.placenta.2006.08.002
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
DOI	10.1074/jbc.274.3.1621	http://dx.doi.org/10.1074/jbc.274.3.1621
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF102166	http://www.ebi.ac.uk/ena/data/view/AF102166
EMBL	AL807752	http://www.ebi.ac.uk/ena/data/view/AL807752
EMBL	BC007012	http://www.ebi.ac.uk/ena/data/view/BC007012
EMBL	CH471090	http://www.ebi.ac.uk/ena/data/view/CH471090
Ensembl	ENST00000494426	http://www.ensembl.org/id/ENST00000494426
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005244
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_process	GO:0006821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006821
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
Gene3D	1.20.1050.10	http://www.cathdb.info/version/latest/superfamily/1.20.1050.10
Gene3D	3.40.30.10	http://www.cathdb.info/version/latest/superfamily/3.40.30.10
GeneCards	CLIC3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CLIC3
GeneID	9022	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9022
GeneTree	ENSGT00550000074477	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074477
HGNC	HGNC:2064	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2064
HOGENOM	HOG000231548	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231548&db=HOGENOM6
HOVERGEN	HBG050994	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050994&db=HOVERGEN
HPA	HPA005963	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA005963
InParanoid	O95833	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O95833
IntAct	O95833	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O95833*
InterPro	IPR002946	http://www.ebi.ac.uk/interpro/entry/IPR002946
InterPro	IPR004045	http://www.ebi.ac.uk/interpro/entry/IPR004045
InterPro	IPR010987	http://www.ebi.ac.uk/interpro/entry/IPR010987
InterPro	IPR012336	http://www.ebi.ac.uk/interpro/entry/IPR012336
InterPro	IPR030261	http://www.ebi.ac.uk/interpro/entry/IPR030261
Jabion	9022	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9022
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:9022	http://www.genome.jp/dbget-bin/www_bget?hsa:9022
KEGG_Orthology	KO:K05023	http://www.genome.jp/dbget-bin/www_bget?KO:K05023
MIM	606533	http://www.ncbi.nlm.nih.gov/omim/606533
OMA	QDDALYQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QDDALYQ
OrthoDB	EOG091G0IHT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0IHT
PANTHER	PTHR11260:SF266	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11260:SF266
PDB	3FY7	http://www.ebi.ac.uk/pdbe-srv/view/entry/3FY7
PDB	3KJY	http://www.ebi.ac.uk/pdbe-srv/view/entry/3KJY
PDBsum	3FY7	http://www.ebi.ac.uk/pdbsum/3FY7
PDBsum	3KJY	http://www.ebi.ac.uk/pdbsum/3KJY
PRINTS	PR01263	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01263
PROSITE	PS50404	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50404
PROSITE	PS50405	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50405
PSORT	swissprot:CLIC3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CLIC3_HUMAN
PSORT-B	swissprot:CLIC3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CLIC3_HUMAN
PSORT2	swissprot:CLIC3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CLIC3_HUMAN
Pfam	PF13417	http://pfam.xfam.org/family/PF13417
PharmGKB	PA26590	http://www.pharmgkb.org/do/serve?objId=PA26590&objCls=Gene
Phobius	swissprot:CLIC3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CLIC3_HUMAN
PhylomeDB	O95833	http://phylomedb.org/?seqid=O95833
ProteinModelPortal	O95833	http://www.proteinmodelportal.org/query/uniprot/O95833
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17027078	http://www.ncbi.nlm.nih.gov/pubmed/17027078
PubMed	20146363	http://www.ncbi.nlm.nih.gov/pubmed/20146363
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	9880541	http://www.ncbi.nlm.nih.gov/pubmed/9880541
RefSeq	NP_004660	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004660
RefSeq	XP_016870771	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016870771
SMR	O95833	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O95833
STRING	9606.ENSP00000419378	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000419378&targetmode=cogs
SUPFAM	SSF47616	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47616
SUPFAM	SSF52833	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833
TCDB	1.A.12.1	http://www.tcdb.org/search/result.php?tc=1.A.12.1
UCSC	uc004ckj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004ckj&org=rat
UniGene	Hs.64746	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.64746
UniProtKB	CLIC3_HUMAN	http://www.uniprot.org/uniprot/CLIC3_HUMAN
UniProtKB-AC	O95833	http://www.uniprot.org/uniprot/O95833
charge	swissprot:CLIC3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CLIC3_HUMAN
eggNOG	ENOG410INGX	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410INGX
eggNOG	ENOG41128FW	http://eggnogapi.embl.de/nog_data/html/tree/ENOG41128FW
epestfind	swissprot:CLIC3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CLIC3_HUMAN
garnier	swissprot:CLIC3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CLIC3_HUMAN
helixturnhelix	swissprot:CLIC3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLIC3_HUMAN
hmoment	swissprot:CLIC3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CLIC3_HUMAN
iep	swissprot:CLIC3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CLIC3_HUMAN
inforesidue	swissprot:CLIC3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CLIC3_HUMAN
neXtProt	NX_O95833	http://www.nextprot.org/db/entry/NX_O95833
octanol	swissprot:CLIC3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CLIC3_HUMAN
pepcoil	swissprot:CLIC3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CLIC3_HUMAN
pepdigest	swissprot:CLIC3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CLIC3_HUMAN
pepinfo	swissprot:CLIC3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CLIC3_HUMAN
pepnet	swissprot:CLIC3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CLIC3_HUMAN
pepstats	swissprot:CLIC3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CLIC3_HUMAN
pepwheel	swissprot:CLIC3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CLIC3_HUMAN
pepwindow	swissprot:CLIC3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CLIC3_HUMAN
sigcleave	swissprot:CLIC3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CLIC3_HUMAN
## Database	ID	URL or Descriptions
# AltName	GBRA3_HUMAN	GABA(A) receptor subunit alpha-3
# BioGrid	108830	20
# ChiTaRS	GABRA3	human
# DrugBank	DB00186	Lorazepam
# DrugBank	DB00189	Ethchlorvynol
# DrugBank	DB00228	Enflurane
# DrugBank	DB00231	Temazepam
# DrugBank	DB00237	Butabarbital
# DrugBank	DB00241	Butalbital
# DrugBank	DB00273	Topiramate
# DrugBank	DB00292	Etomidate
# DrugBank	DB00306	Talbutal
# DrugBank	DB00312	Pentobarbital
# DrugBank	DB00334	Olanzapine
# DrugBank	DB00349	Clobazam
# DrugBank	DB00371	Meprobamate
# DrugBank	DB00402	Eszopiclone
# DrugBank	DB00404	Alprazolam
# DrugBank	DB00418	Secobarbital
# DrugBank	DB00425	Zolpidem
# DrugBank	DB00475	Chlordiazepoxide
# DrugBank	DB00543	Amoxapine
# DrugBank	DB00546	Adinazolam
# DrugBank	DB00599	Thiopental
# DrugBank	DB00628	Clorazepate
# DrugBank	DB00659	Acamprosate
# DrugBank	DB00683	Midazolam
# DrugBank	DB00690	Flurazepam
# DrugBank	DB00753	Isoflurane
# DrugBank	DB00794	Primidone
# DrugBank	DB00801	Halazepam
# DrugBank	DB00818	Propofol
# DrugBank	DB00829	Diazepam
# DrugBank	DB00842	Oxazepam
# DrugBank	DB00849	Methylphenobarbital
# DrugBank	DB00897	Triazolam
# DrugBank	DB00898	Ethanol
# DrugBank	DB01028	Methoxyflurane
# DrugBank	DB01049	Ergoloid mesylate
# DrugBank	DB01068	Clonazepam
# DrugBank	DB01107	Methyprylon
# DrugBank	DB01159	Halothane
# DrugBank	DB01189	Desflurane
# DrugBank	DB01198	Zopiclone
# DrugBank	DB01205	Flumazenil
# DrugBank	DB01215	Estazolam
# DrugBank	DB01236	Sevoflurane
# DrugBank	DB01351	Amobarbital
# DrugBank	DB01352	Aprobarbital
# DrugBank	DB01353	Butethal
# DrugBank	DB01354	Heptabarbital
# DrugBank	DB01355	Hexobarbital
# DrugBank	DB01437	Glutethimide
# DrugBank	DB01544	Flunitrazepam
# DrugBank	DB01558	Bromazepam
# DrugBank	DB01559	Clotiazepam
# DrugBank	DB01567	Fludiazepam
# DrugBank	DB01588	Prazepam
# DrugBank	DB01589	Quazepam
# DrugBank	DB01594	Cinolazepam
# DrugBank	DB01595	Nitrazepam
# Ensembl	ENST00000370314	ENSP00000359337; ENSG00000011677
# Ensembl	ENST00000535043	ENSP00000443527; ENSG00000011677
# FUNCTION	GBRA3_HUMAN	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:1902711	GABA-A receptor complex; IBA:GO_Central.
# GO_function	GO:0004890	GABA-A receptor activity; IEA:InterPro.
# GO_function	GO:0005230	extracellular ligand-gated ion channel activity; IEA:InterPro.
# GO_function	GO:0005254	chloride channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0008503	benzodiazepine receptor activity; TAS:ProtInc.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007214	gamma-aminobutyric acid signaling pathway; TAS:ProtInc.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.70.170.10	-; 1.
# Genevisible	P34903	HS
# HGNC	HGNC:4077	GABRA3
# IntAct	P34903	3
# InterPro	IPR001390	GABAAa_rcpt
# InterPro	IPR005433	GABBAa3_rcpt
# InterPro	IPR006028	GABAA/Glycine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04727	GABAergic synapse
# KEGG_Pathway	ko05032	Morphine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# MIM	305660	gene
# Organism	GBRA3_HUMAN	Homo sapiens (Human)
# Orphanet	79102	Thyrotoxic periodic paralysis
# PANTHER	PTHR18945	PTHR18945; 2
# PIR	I77911	I77911
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00253	GABAARECEPTR
# PRINTS	PR01079	GABAARALPHA
# PRINTS	PR01616	GABAARALPHA3
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-112314	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
# Reactome	R-HSA-975298	Ligand-gated ion channel transport
# Reactome	R-HSA-977441	GABA A receptor activation
# RecName	GBRA3_HUMAN	Gamma-aminobutyric acid receptor subunit alpha-3
# RefSeq	NP_000799	NM_000808.3
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA3 sub-subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	GBRA3_HUMAN	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	GBRA3_HUMAN	Generally pentameric. There are five types of GABA(A) receptor chains  alpha, beta, gamma, delta, and rho. Binds UBQLN1 (By similarity). Interacts with GPHN (PubMed 26613940). {ECO 0000250|UniProtKB P26049, ECO 0000269|PubMed 26613940}. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TIGRFAMs	TIGR00860	LIC
# UCSC	uc010ntk	human
# WEB RESOURCE	GBRA3_HUMAN	Name=Protein Spotlight; Note=Forbidden fruit - Issue 56 of March 2005; URL="http //web.expasy.org/spotlight/back_issues/056";
# eggNOG	ENOG410XNQG	LUCA
# eggNOG	KOG3642	Eukaryota
BLAST	swissprot:GBRA3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GBRA3_HUMAN
BioCyc	ZFISH:ENSG00000011677-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000011677-MONOMER
COXPRESdb	2556	http://coxpresdb.jp/data/gene/2556.shtml
CleanEx	HS_GABRA3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GABRA3
DOI	10.1002/(SICI)1096-8628(20000103)90:1<69::AID-AJMG12>3.3.CO	http://dx.doi.org/10.1002/(SICI)1096-8628(20000103)90:1<69::AID-AJMG12>3.3.CO
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.15252/emmm.201505323	http://dx.doi.org/10.15252/emmm.201505323
DrugBank	DB00186	http://www.drugbank.ca/drugs/DB00186
DrugBank	DB00189	http://www.drugbank.ca/drugs/DB00189
DrugBank	DB00228	http://www.drugbank.ca/drugs/DB00228
DrugBank	DB00231	http://www.drugbank.ca/drugs/DB00231
DrugBank	DB00237	http://www.drugbank.ca/drugs/DB00237
DrugBank	DB00241	http://www.drugbank.ca/drugs/DB00241
DrugBank	DB00273	http://www.drugbank.ca/drugs/DB00273
DrugBank	DB00292	http://www.drugbank.ca/drugs/DB00292
DrugBank	DB00306	http://www.drugbank.ca/drugs/DB00306
DrugBank	DB00312	http://www.drugbank.ca/drugs/DB00312
DrugBank	DB00334	http://www.drugbank.ca/drugs/DB00334
DrugBank	DB00349	http://www.drugbank.ca/drugs/DB00349
DrugBank	DB00371	http://www.drugbank.ca/drugs/DB00371
DrugBank	DB00402	http://www.drugbank.ca/drugs/DB00402
DrugBank	DB00404	http://www.drugbank.ca/drugs/DB00404
DrugBank	DB00418	http://www.drugbank.ca/drugs/DB00418
DrugBank	DB00425	http://www.drugbank.ca/drugs/DB00425
DrugBank	DB00475	http://www.drugbank.ca/drugs/DB00475
DrugBank	DB00543	http://www.drugbank.ca/drugs/DB00543
DrugBank	DB00546	http://www.drugbank.ca/drugs/DB00546
DrugBank	DB00599	http://www.drugbank.ca/drugs/DB00599
DrugBank	DB00628	http://www.drugbank.ca/drugs/DB00628
DrugBank	DB00659	http://www.drugbank.ca/drugs/DB00659
DrugBank	DB00683	http://www.drugbank.ca/drugs/DB00683
DrugBank	DB00690	http://www.drugbank.ca/drugs/DB00690
DrugBank	DB00753	http://www.drugbank.ca/drugs/DB00753
DrugBank	DB00794	http://www.drugbank.ca/drugs/DB00794
DrugBank	DB00801	http://www.drugbank.ca/drugs/DB00801
DrugBank	DB00818	http://www.drugbank.ca/drugs/DB00818
DrugBank	DB00829	http://www.drugbank.ca/drugs/DB00829
DrugBank	DB00842	http://www.drugbank.ca/drugs/DB00842
DrugBank	DB00849	http://www.drugbank.ca/drugs/DB00849
DrugBank	DB00897	http://www.drugbank.ca/drugs/DB00897
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01028	http://www.drugbank.ca/drugs/DB01028
DrugBank	DB01049	http://www.drugbank.ca/drugs/DB01049
DrugBank	DB01068	http://www.drugbank.ca/drugs/DB01068
DrugBank	DB01107	http://www.drugbank.ca/drugs/DB01107
DrugBank	DB01159	http://www.drugbank.ca/drugs/DB01159
DrugBank	DB01189	http://www.drugbank.ca/drugs/DB01189
DrugBank	DB01198	http://www.drugbank.ca/drugs/DB01198
DrugBank	DB01205	http://www.drugbank.ca/drugs/DB01205
DrugBank	DB01215	http://www.drugbank.ca/drugs/DB01215
DrugBank	DB01236	http://www.drugbank.ca/drugs/DB01236
DrugBank	DB01351	http://www.drugbank.ca/drugs/DB01351
DrugBank	DB01352	http://www.drugbank.ca/drugs/DB01352
DrugBank	DB01353	http://www.drugbank.ca/drugs/DB01353
DrugBank	DB01354	http://www.drugbank.ca/drugs/DB01354
DrugBank	DB01355	http://www.drugbank.ca/drugs/DB01355
DrugBank	DB01437	http://www.drugbank.ca/drugs/DB01437
DrugBank	DB01544	http://www.drugbank.ca/drugs/DB01544
DrugBank	DB01558	http://www.drugbank.ca/drugs/DB01558
DrugBank	DB01559	http://www.drugbank.ca/drugs/DB01559
DrugBank	DB01567	http://www.drugbank.ca/drugs/DB01567
DrugBank	DB01588	http://www.drugbank.ca/drugs/DB01588
DrugBank	DB01589	http://www.drugbank.ca/drugs/DB01589
DrugBank	DB01594	http://www.drugbank.ca/drugs/DB01594
DrugBank	DB01595	http://www.drugbank.ca/drugs/DB01595
EMBL	AF165901	http://www.ebi.ac.uk/ena/data/view/AF165901
EMBL	AF165902	http://www.ebi.ac.uk/ena/data/view/AF165902
EMBL	AF165903	http://www.ebi.ac.uk/ena/data/view/AF165903
EMBL	AF165904	http://www.ebi.ac.uk/ena/data/view/AF165904
EMBL	AF165905	http://www.ebi.ac.uk/ena/data/view/AF165905
EMBL	AF165906	http://www.ebi.ac.uk/ena/data/view/AF165906
EMBL	AF166359	http://www.ebi.ac.uk/ena/data/view/AF166359
EMBL	AF166360	http://www.ebi.ac.uk/ena/data/view/AF166360
EMBL	AF166361	http://www.ebi.ac.uk/ena/data/view/AF166361
EMBL	BC028629	http://www.ebi.ac.uk/ena/data/view/BC028629
EMBL	S62908	http://www.ebi.ac.uk/ena/data/view/S62908
Ensembl	ENST00000370314	http://www.ensembl.org/id/ENST00000370314
Ensembl	ENST00000535043	http://www.ensembl.org/id/ENST00000535043
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_component	GO:1902711	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902711
GO_function	GO:0004890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004890
GO_function	GO:0005230	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005230
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0008503	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008503
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007214	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007214
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	GABRA3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GABRA3
GeneID	2556	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2556
GeneTree	ENSGT00760000119010	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119010
HGNC	HGNC:4077	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4077
HOGENOM	HOG000231337	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231337&db=HOGENOM6
HOVERGEN	HBG051707	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051707&db=HOVERGEN
HPA	HPA000839	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA000839
InParanoid	P34903	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P34903
IntAct	P34903	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P34903*
InterPro	IPR001390	http://www.ebi.ac.uk/interpro/entry/IPR001390
InterPro	IPR005433	http://www.ebi.ac.uk/interpro/entry/IPR005433
InterPro	IPR006028	http://www.ebi.ac.uk/interpro/entry/IPR006028
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
Jabion	2556	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2556
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:2556	http://www.genome.jp/dbget-bin/www_bget?hsa:2556
KEGG_Orthology	KO:K05175	http://www.genome.jp/dbget-bin/www_bget?KO:K05175
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
KEGG_Pathway	ko05032	http://www.genome.jp/kegg-bin/show_pathway?ko05032
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
MIM	305660	http://www.ncbi.nlm.nih.gov/omim/305660
MINT	MINT-7242442	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-7242442
OMA	YNIVGTT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YNIVGTT
Orphanet	79102	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=79102
OrthoDB	EOG091G0805	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0805
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00253	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00253
PRINTS	PR01079	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01079
PRINTS	PR01616	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01616
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:GBRA3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GBRA3_HUMAN
PSORT-B	swissprot:GBRA3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GBRA3_HUMAN
PSORT2	swissprot:GBRA3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GBRA3_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA28491	http://www.pharmgkb.org/do/serve?objId=PA28491&objCls=Gene
Phobius	swissprot:GBRA3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GBRA3_HUMAN
PhylomeDB	P34903	http://phylomedb.org/?seqid=P34903
ProteinModelPortal	P34903	http://www.proteinmodelportal.org/query/uniprot/P34903
PubMed	10602120	http://www.ncbi.nlm.nih.gov/pubmed/10602120
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	26613940	http://www.ncbi.nlm.nih.gov/pubmed/26613940
PubMed	8391122	http://www.ncbi.nlm.nih.gov/pubmed/8391122
Reactome	R-HSA-112314	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112314
Reactome	R-HSA-975298	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-975298
Reactome	R-HSA-977441	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-977441
RefSeq	NP_000799	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000799
STRING	9606.ENSP00000359334	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000359334&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc010ntk	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010ntk&org=rat
UniGene	Hs.123024	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.123024
UniProtKB	GBRA3_HUMAN	http://www.uniprot.org/uniprot/GBRA3_HUMAN
UniProtKB-AC	P34903	http://www.uniprot.org/uniprot/P34903
charge	swissprot:GBRA3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GBRA3_HUMAN
eggNOG	ENOG410XNQG	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNQG
eggNOG	KOG3642	http://eggnogapi.embl.de/nog_data/html/tree/KOG3642
epestfind	swissprot:GBRA3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GBRA3_HUMAN
garnier	swissprot:GBRA3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GBRA3_HUMAN
helixturnhelix	swissprot:GBRA3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GBRA3_HUMAN
hmoment	swissprot:GBRA3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GBRA3_HUMAN
iep	swissprot:GBRA3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GBRA3_HUMAN
inforesidue	swissprot:GBRA3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GBRA3_HUMAN
neXtProt	NX_P34903	http://www.nextprot.org/db/entry/NX_P34903
octanol	swissprot:GBRA3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GBRA3_HUMAN
pepcoil	swissprot:GBRA3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GBRA3_HUMAN
pepdigest	swissprot:GBRA3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GBRA3_HUMAN
pepinfo	swissprot:GBRA3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GBRA3_HUMAN
pepnet	swissprot:GBRA3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GBRA3_HUMAN
pepstats	swissprot:GBRA3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GBRA3_HUMAN
pepwheel	swissprot:GBRA3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GBRA3_HUMAN
pepwindow	swissprot:GBRA3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GBRA3_HUMAN
sigcleave	swissprot:GBRA3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GBRA3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=5-HT3R-AS; IsoId=P46098-1; Sequence=Displayed; Name=2; Synonyms=5-HT3R-AL; IsoId=P46098-2; Sequence=VSP_000078; Name=3; IsoId=P46098-3; Sequence=VSP_042214; Name=4; IsoId=P46098-4; Sequence=VSP_043484; Note=No experimental confirmation available.; Name=5; IsoId=P46098-5; Sequence=VSP_043484, VSP_000078; Note=No experimental confirmation available. Ref.7 (CD014118) sequence is in conflict in position: 342	C->W. {ECO:0000305}; 
# AltName	5HT3A_HUMAN	5-hydroxytryptamine receptor 3
# AltName	5HT3A_HUMAN	Serotonin receptor 3A
# AltName	5HT3A_HUMAN	Serotonin-gated ion channel receptor
# BioGrid	109591	97
# CCDS	CCDS53710	-. [P46098-3]
# CCDS	CCDS8365	-. [P46098-4]
# CCDS	CCDS8366	-. [P46098-5]
# DrugBank	DB00246	Ziprasidone
# DrugBank	DB00333	Methadone
# DrugBank	DB00334	Olanzapine
# DrugBank	DB00363	Clozapine
# DrugBank	DB00370	Mirtazapine
# DrugBank	DB00377	Palonosetron
# DrugBank	DB00408	Loxapine
# DrugBank	DB00543	Amoxapine
# DrugBank	DB00604	Cisapride
# DrugBank	DB00721	Procaine
# DrugBank	DB00726	Trimipramine
# DrugBank	DB00728	Rocuronium
# DrugBank	DB00757	Dolasetron
# DrugBank	DB00889	Granisetron
# DrugBank	DB00898	Ethanol
# DrugBank	DB00904	Ondansetron
# DrugBank	DB00969	Alosetron
# DrugBank	DB01043	Memantine
# DrugBank	DB01049	Ergoloid mesylate
# DrugBank	DB01161	Chloroprocaine
# DrugBank	DB01199	Tubocurarine
# DrugBank	DB01224	Quetiapine
# DrugBank	DB01233	Metoclopramide
# DrugBank	DB01238	Aripiprazole
# DrugBank	DB06204	Tapentadol
# DrugBank	DB09068	Vortioxetine
# Ensembl	ENST00000299961	ENSP00000299961; ENSG00000166736. [P46098-3]
# Ensembl	ENST00000355556	ENSP00000347754; ENSG00000166736. [P46098-5]
# Ensembl	ENST00000375498	ENSP00000364648; ENSG00000166736. [P46098-4]
# Ensembl	ENST00000504030	ENSP00000424189; ENSG00000166736. [P46098-1]
# Ensembl	ENST00000506841	ENSP00000424776; ENSG00000166736. [P46098-2]
# ExpressionAtlas	P46098	baseline and differential
# FUNCTION	5HT3A_HUMAN	This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. {ECO 0000269|PubMed 12867984, ECO 0000269|PubMed 9950429}. 
# GO_component	GO:0005737	cytoplasm; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030424	axon; IEA:Ensembl.
# GO_component	GO:0043025	neuronal cell body; IEA:Ensembl.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:1904602	serotonin-activated cation-selective channel complex; IDA:GO_Central.
# GO_function	GO:0005232	serotonin-activated cation-selective channel activity; IDA:GO_Central.
# GO_function	GO:0022850	serotonin-gated cation channel activity; IDA:MGI.
# GO_function	GO:0051378	serotonin binding; IDA:MGI.
# GO_process	GO:0032414	positive regulation of ion transmembrane transporter activity; IEA:Ensembl.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0042220	response to cocaine; IEA:Ensembl.
# GO_process	GO:0045471	response to ethanol; IEA:Ensembl.
# GO_process	GO:0071363	cellular response to growth factor stimulus; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.370	-; 2.
# Gene3D	2.70.170.10	-; 1.
# Genevisible	P46098	HS
# HGNC	HGNC:5297	HTR3A
# INTERACTION	5HT3A_HUMAN	Q8WXA8 HTR3C; NbExp=5; IntAct=EBI-9008743, EBI-9008753; Q70Z44 HTR3D; NbExp=5; IntAct=EBI-9008743, EBI-9008717; A5X5Y0-1 HTR3E; NbExp=5; IntAct=EBI-9008743, EBI-11174612; A5X5Y0-3 HTR3E; NbExp=3; IntAct=EBI-9008743, EBI-11163690; 
# IntAct	P46098	4
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR008132	5HT3_rcpt
# InterPro	IPR008133	5HT3_rcpt_A
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# InterPro	IPR027361	Acetylcholine_rcpt_TM
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04726	Serotonergic synapse
# MIM	182139	gene
# MISCELLANEOUS	5HT3A_HUMAN	The HA-stretch region of HTR3A seems to be responsible for the low conductance of HTR3A homomers compared to that of HTR3A/HTR3B heteromers. 
# Organism	5HT3A_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR18945	PTHR18945
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR01708	5HT3RECEPTOR
# PRINTS	PR01709	5HT3ARECEPTR
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-975298	Ligand-gated ion channel transport
# RecName	5HT3A_HUMAN	5-hydroxytryptamine receptor 3A
# RefSeq	NP_000860	NM_000869.5. [P46098-4]
# RefSeq	NP_001155244	NM_001161772.2. [P46098-3]
# RefSeq	NP_998786	NM_213621.3. [P46098-5]
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	5HT3A_HUMAN	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	5HT3A_HUMAN	Forms pentahomomeric complex as well as pentaheteromeric complex with HTR3B or HTR3C or HTR3D or HTR3E; homomeric complex is functional but exhibits low conductance with modified voltage dependence, and decreased agonist and antagonist affinity. Interacts with RIC3. {ECO 0000269|PubMed 10521471, ECO 0000269|PubMed 15809299, ECO 0000269|PubMed 17392525, ECO 0000269|PubMed 9950429}. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TCDB	1.A.9.2	the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family
# TIGRFAMs	TIGR00860	LIC
# TISSUE SPECIFICITY	Expressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of the spleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta. {ECO:0000269|PubMed	10521471}. 
# UCSC	uc010rxa	human. [P46098-1]
BLAST	swissprot:5HT3A_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:5HT3A_HUMAN
BioCyc	ZFISH:ENSG00000166736-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000166736-MONOMER
COXPRESdb	3359	http://coxpresdb.jp/data/gene/3359.shtml
CleanEx	HS_HTR3A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_HTR3A
DOI	10.1007/s10067-004-0927-2	http://dx.doi.org/10.1007/s10067-004-0927-2
DOI	10.1016/S0028-3908(99)00116-1	http://dx.doi.org/10.1016/S0028-3908(99)00116-1
DOI	10.1016/j.biopsych.2005.11.008	http://dx.doi.org/10.1016/j.biopsych.2005.11.008
DOI	10.1016/j.ygeno.2003.09.023	http://dx.doi.org/10.1016/j.ygeno.2003.09.023
DOI	10.1038/16941	http://dx.doi.org/10.1038/16941
DOI	10.1038/nature01788	http://dx.doi.org/10.1038/nature01788
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.274.43.30799	http://dx.doi.org/10.1074/jbc.274.43.30799
DOI	10.1074/jbc.M414341200	http://dx.doi.org/10.1074/jbc.M414341200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1749-6632.1998.tb10196.x	http://dx.doi.org/10.1111/j.1749-6632.1998.tb10196.x
DOI	10.1124/mol.106.032144	http://dx.doi.org/10.1124/mol.106.032144
DrugBank	DB00246	http://www.drugbank.ca/drugs/DB00246
DrugBank	DB00333	http://www.drugbank.ca/drugs/DB00333
DrugBank	DB00334	http://www.drugbank.ca/drugs/DB00334
DrugBank	DB00363	http://www.drugbank.ca/drugs/DB00363
DrugBank	DB00370	http://www.drugbank.ca/drugs/DB00370
DrugBank	DB00377	http://www.drugbank.ca/drugs/DB00377
DrugBank	DB00408	http://www.drugbank.ca/drugs/DB00408
DrugBank	DB00543	http://www.drugbank.ca/drugs/DB00543
DrugBank	DB00604	http://www.drugbank.ca/drugs/DB00604
DrugBank	DB00721	http://www.drugbank.ca/drugs/DB00721
DrugBank	DB00726	http://www.drugbank.ca/drugs/DB00726
DrugBank	DB00728	http://www.drugbank.ca/drugs/DB00728
DrugBank	DB00757	http://www.drugbank.ca/drugs/DB00757
DrugBank	DB00889	http://www.drugbank.ca/drugs/DB00889
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB00904	http://www.drugbank.ca/drugs/DB00904
DrugBank	DB00969	http://www.drugbank.ca/drugs/DB00969
DrugBank	DB01043	http://www.drugbank.ca/drugs/DB01043
DrugBank	DB01049	http://www.drugbank.ca/drugs/DB01049
DrugBank	DB01161	http://www.drugbank.ca/drugs/DB01161
DrugBank	DB01199	http://www.drugbank.ca/drugs/DB01199
DrugBank	DB01224	http://www.drugbank.ca/drugs/DB01224
DrugBank	DB01233	http://www.drugbank.ca/drugs/DB01233
DrugBank	DB01238	http://www.drugbank.ca/drugs/DB01238
DrugBank	DB06204	http://www.drugbank.ca/drugs/DB06204
DrugBank	DB09068	http://www.drugbank.ca/drugs/DB09068
EMBL	AF498984	http://www.ebi.ac.uk/ena/data/view/AF498984
EMBL	AJ003078	http://www.ebi.ac.uk/ena/data/view/AJ003078
EMBL	AJ003079	http://www.ebi.ac.uk/ena/data/view/AJ003079
EMBL	AJ005205	http://www.ebi.ac.uk/ena/data/view/AJ005205
EMBL	AK299973	http://www.ebi.ac.uk/ena/data/view/AK299973
EMBL	AP000908	http://www.ebi.ac.uk/ena/data/view/AP000908
EMBL	BC002354	http://www.ebi.ac.uk/ena/data/view/BC002354
EMBL	BC004453	http://www.ebi.ac.uk/ena/data/view/BC004453
EMBL	BT007204	http://www.ebi.ac.uk/ena/data/view/BT007204
EMBL	CD014118	http://www.ebi.ac.uk/ena/data/view/CD014118
EMBL	CH471065	http://www.ebi.ac.uk/ena/data/view/CH471065
EMBL	CH471065	http://www.ebi.ac.uk/ena/data/view/CH471065
EMBL	D49394	http://www.ebi.ac.uk/ena/data/view/D49394
EMBL	S82612	http://www.ebi.ac.uk/ena/data/view/S82612
Ensembl	ENST00000299961	http://www.ensembl.org/id/ENST00000299961
Ensembl	ENST00000355556	http://www.ensembl.org/id/ENST00000355556
Ensembl	ENST00000375498	http://www.ensembl.org/id/ENST00000375498
Ensembl	ENST00000504030	http://www.ensembl.org/id/ENST00000504030
Ensembl	ENST00000506841	http://www.ensembl.org/id/ENST00000506841
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030424	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030424
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_component	GO:1904602	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1904602
GO_function	GO:0005232	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005232
GO_function	GO:0022850	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022850
GO_function	GO:0051378	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051378
GO_process	GO:0032414	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032414
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0042220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042220
GO_process	GO:0045471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045471
GO_process	GO:0071363	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071363
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.370	http://www.cathdb.info/version/latest/superfamily/1.20.120.370
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	HTR3A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=HTR3A
GeneID	3359	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3359
GeneTree	ENSGT00790000122957	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00790000122957
HGNC	HGNC:5297	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:5297
HOGENOM	HOG000241519	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000241519&db=HOGENOM6
HOVERGEN	HBG106638	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG106638&db=HOVERGEN
InParanoid	P46098	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46098
IntAct	P46098	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P46098*
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR008132	http://www.ebi.ac.uk/interpro/entry/IPR008132
InterPro	IPR008133	http://www.ebi.ac.uk/interpro/entry/IPR008133
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
InterPro	IPR027361	http://www.ebi.ac.uk/interpro/entry/IPR027361
Jabion	3359	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3359
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3359	http://www.genome.jp/dbget-bin/www_bget?hsa:3359
KEGG_Orthology	KO:K04819	http://www.genome.jp/dbget-bin/www_bget?KO:K04819
KEGG_Pathway	ko04726	http://www.genome.jp/kegg-bin/show_pathway?ko04726
MIM	182139	http://www.ncbi.nlm.nih.gov/omim/182139
OMA	HGEVQNY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HGEVQNY
OrthoDB	EOG091G06Q8	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G06Q8
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR01708	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01708
PRINTS	PR01709	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01709
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:5HT3A_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:5HT3A_HUMAN
PSORT-B	swissprot:5HT3A_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:5HT3A_HUMAN
PSORT2	swissprot:5HT3A_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:5HT3A_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA29555	http://www.pharmgkb.org/do/serve?objId=PA29555&objCls=Gene
Phobius	swissprot:5HT3A_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:5HT3A_HUMAN
PhylomeDB	P46098	http://phylomedb.org/?seqid=P46098
ProteinModelPortal	P46098	http://www.proteinmodelportal.org/query/uniprot/P46098
PubMed	10521471	http://www.ncbi.nlm.nih.gov/pubmed/10521471
PubMed	10670426	http://www.ncbi.nlm.nih.gov/pubmed/10670426
PubMed	12867984	http://www.ncbi.nlm.nih.gov/pubmed/12867984
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15028279	http://www.ncbi.nlm.nih.gov/pubmed/15028279
PubMed	15293096	http://www.ncbi.nlm.nih.gov/pubmed/15293096
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15809299	http://www.ncbi.nlm.nih.gov/pubmed/15809299
PubMed	16487942	http://www.ncbi.nlm.nih.gov/pubmed/16487942
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	17392525	http://www.ncbi.nlm.nih.gov/pubmed/17392525
PubMed	7565620	http://www.ncbi.nlm.nih.gov/pubmed/7565620
PubMed	8848005	http://www.ncbi.nlm.nih.gov/pubmed/8848005
PubMed	9928262	http://www.ncbi.nlm.nih.gov/pubmed/9928262
PubMed	9950429	http://www.ncbi.nlm.nih.gov/pubmed/9950429
Reactome	R-HSA-975298	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-975298
RefSeq	NP_000860	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000860
RefSeq	NP_001155244	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001155244
RefSeq	NP_998786	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_998786
SMR	P46098	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P46098
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TCDB	1.A.9.2	http://www.tcdb.org/search/result.php?tc=1.A.9.2
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc010rxa	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010rxa&org=rat
UniGene	Hs.413899	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.413899
UniProtKB	5HT3A_HUMAN	http://www.uniprot.org/uniprot/5HT3A_HUMAN
UniProtKB-AC	P46098	http://www.uniprot.org/uniprot/P46098
charge	swissprot:5HT3A_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:5HT3A_HUMAN
epestfind	swissprot:5HT3A_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:5HT3A_HUMAN
garnier	swissprot:5HT3A_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:5HT3A_HUMAN
helixturnhelix	swissprot:5HT3A_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:5HT3A_HUMAN
hmoment	swissprot:5HT3A_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:5HT3A_HUMAN
iep	swissprot:5HT3A_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:5HT3A_HUMAN
inforesidue	swissprot:5HT3A_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:5HT3A_HUMAN
neXtProt	NX_P46098	http://www.nextprot.org/db/entry/NX_P46098
octanol	swissprot:5HT3A_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:5HT3A_HUMAN
pepcoil	swissprot:5HT3A_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:5HT3A_HUMAN
pepdigest	swissprot:5HT3A_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:5HT3A_HUMAN
pepinfo	swissprot:5HT3A_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:5HT3A_HUMAN
pepnet	swissprot:5HT3A_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:5HT3A_HUMAN
pepstats	swissprot:5HT3A_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:5HT3A_HUMAN
pepwheel	swissprot:5HT3A_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:5HT3A_HUMAN
pepwindow	swissprot:5HT3A_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:5HT3A_HUMAN
sigcleave	swissprot:5HT3A_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:5HT3A_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCND1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NSA2-1; Sequence=Displayed; Name=2; IsoId=Q9NSA2-2; Sequence=VSP_057040; Note=No experimental confirmation available.; 
# AltName	KCND1_HUMAN	Voltage-gated potassium channel subunit Kv4.1
# CCDS	CCDS14314	-. [Q9NSA2-1]
# DOMAIN	KCND1_HUMAN	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. 
# DrugBank	DB06637	Dalfampridine
# Ensembl	ENST00000218176	ENSP00000218176; ENSG00000102057. [Q9NSA2-1]
# Ensembl	ENST00000376477	ENSP00000365660; ENSG00000102057. [Q9NSA2-2]
# ExpressionAtlas	Q9NSA2	baseline and differential
# FUNCTION	KCND1_HUMAN	Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IEA:InterPro.
# GO_component	GO:0016021	integral component of membrane; IBA:GO_Central.
# GO_component	GO:0030425	dendrite; IEA:UniProtKB-SubCell.
# GO_component	GO:0043025	neuronal cell body; IEA:Ensembl.
# GO_function	GO:0005250	A-type (transient outward) potassium channel activity; IBA:GO_Central.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0051260	protein homooligomerization; IEA:InterPro.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.20.120.350	-; 1.
# Genevisible	Q9NSA2	HS
# HGNC	HGNC:6237	KCND1
# InterPro	IPR000210	BTB/POZ_dom
# InterPro	IPR003131	T1-type_BTB
# InterPro	IPR003968	K_chnl_volt-dep_Kv
# InterPro	IPR003975	K_chnl_volt-dep_Kv4
# InterPro	IPR004054	K_chnl_volt-dep_Kv4.1
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR011333	SKP1/BTB/POZ
# InterPro	IPR021645	Shal-type_N
# InterPro	IPR024587	K_chnl_volt-dep_Kv4_C
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko04040	Ion channels
# MIM	300281	gene
# Organism	KCND1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11537	PTHR11537
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01491	KVCHANNEL
# PRINTS	PR01497	SHALCHANNEL
# PRINTS	PR01516	KV41CHANNEL
# Pfam	PF00520	Ion_trans
# Pfam	PF02214	BTB_2
# Pfam	PF11601	Shal-type
# Pfam	PF11879	DUF3399
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# Reactome	R-HSA-5576894	Phase 1 - inactivation of fast Na+ channels
# RecName	KCND1_HUMAN	Potassium voltage-gated channel subfamily D member 1
# RefSeq	NP_004970	NM_004979.5. [Q9NSA2-1]
# RefSeq	XP_011542212	XM_011543910.2. [Q9NSA2-1]
# SIMILARITY	Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.1/KCND1 sub-subfamily. {ECO	0000305}.
# SMART	SM00225	BTB
# SUBCELLULAR LOCATION	KCND1_HUMAN	Membrane; Multi-pass membrane protein. Cell projection, dendrite {ECO 0000250}. 
# SUBUNIT	Homotetramer or heterotetramer with KCND2 and/or KCND3. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4 (By similarity). Interacts with DPP10 (Probable). {ECO:0000250, ECO	0000305}. 
# SUPFAM	SSF54695	SSF54695
# TISSUE SPECIFICITY	Widely expressed. Highly expressed in brain, in particular in cerebellum and thalamus; detected at lower levels in the other parts of the brain. {ECO:0000269|PubMed	10729221}. 
# UCSC	uc004dlw	human. [Q9NSA2-1]
# eggNOG	COG1226	LUCA
# eggNOG	KOG4390	Eukaryota
BLAST	swissprot:KCND1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCND1_HUMAN
COXPRESdb	3750	http://coxpresdb.jp/data/gene/3750.shtml
CleanEx	HS_KCND1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCND1
DOI	10.1006/geno.2000.6117	http://dx.doi.org/10.1006/geno.2000.6117
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1529/biophysj.104.042358	http://dx.doi.org/10.1529/biophysj.104.042358
DrugBank	DB06637	http://www.drugbank.ca/drugs/DB06637
EMBL	AB021865	http://www.ebi.ac.uk/ena/data/view/AB021865
EMBL	AF166003	http://www.ebi.ac.uk/ena/data/view/AF166003
EMBL	AF166004	http://www.ebi.ac.uk/ena/data/view/AF166004
EMBL	AF166005	http://www.ebi.ac.uk/ena/data/view/AF166005
EMBL	AF166006	http://www.ebi.ac.uk/ena/data/view/AF166006
EMBL	AF207550	http://www.ebi.ac.uk/ena/data/view/AF207550
EMBL	AJ005898	http://www.ebi.ac.uk/ena/data/view/AJ005898
EMBL	AK094431	http://www.ebi.ac.uk/ena/data/view/AK094431
EMBL	AK315092	http://www.ebi.ac.uk/ena/data/view/AK315092
EMBL	BC045659	http://www.ebi.ac.uk/ena/data/view/BC045659
EMBL	CH471224	http://www.ebi.ac.uk/ena/data/view/CH471224
EMBL	CH471224	http://www.ebi.ac.uk/ena/data/view/CH471224
Ensembl	ENST00000218176	http://www.ensembl.org/id/ENST00000218176
Ensembl	ENST00000376477	http://www.ensembl.org/id/ENST00000376477
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_function	GO:0005250	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005250
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	KCND1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCND1
GeneID	3750	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3750
GeneTree	ENSGT00760000118846	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118846
HGNC	HGNC:6237	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6237
HOGENOM	HOG000231013	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231013&db=HOGENOM6
HOVERGEN	HBG106687	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG106687&db=HOVERGEN
HPA	HPA000524	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA000524
HPA	HPA001066	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA001066
InParanoid	Q9NSA2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NSA2
InterPro	IPR000210	http://www.ebi.ac.uk/interpro/entry/IPR000210
InterPro	IPR003131	http://www.ebi.ac.uk/interpro/entry/IPR003131
InterPro	IPR003968	http://www.ebi.ac.uk/interpro/entry/IPR003968
InterPro	IPR003975	http://www.ebi.ac.uk/interpro/entry/IPR003975
InterPro	IPR004054	http://www.ebi.ac.uk/interpro/entry/IPR004054
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR011333	http://www.ebi.ac.uk/interpro/entry/IPR011333
InterPro	IPR021645	http://www.ebi.ac.uk/interpro/entry/IPR021645
InterPro	IPR024587	http://www.ebi.ac.uk/interpro/entry/IPR024587
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	3750	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3750
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3750	http://www.genome.jp/dbget-bin/www_bget?hsa:3750
KEGG_Orthology	KO:K04891	http://www.genome.jp/dbget-bin/www_bget?KO:K04891
MIM	300281	http://www.ncbi.nlm.nih.gov/omim/300281
OMA	PREQPCG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PREQPCG
OrthoDB	EOG091G18X0	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G18X0
PANTHER	PTHR11537	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01491	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01491
PRINTS	PR01497	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01497
PRINTS	PR01516	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01516
PSORT	swissprot:KCND1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCND1_HUMAN
PSORT-B	swissprot:KCND1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCND1_HUMAN
PSORT2	swissprot:KCND1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCND1_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF02214	http://pfam.xfam.org/family/PF02214
Pfam	PF11601	http://pfam.xfam.org/family/PF11601
Pfam	PF11879	http://pfam.xfam.org/family/PF11879
PharmGKB	PA30029	http://www.pharmgkb.org/do/serve?objId=PA30029&objCls=Gene
Phobius	swissprot:KCND1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCND1_HUMAN
PhylomeDB	Q9NSA2	http://phylomedb.org/?seqid=Q9NSA2
ProteinModelPortal	Q9NSA2	http://www.proteinmodelportal.org/query/uniprot/Q9NSA2
PubMed	10729221	http://www.ncbi.nlm.nih.gov/pubmed/10729221
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15454437	http://www.ncbi.nlm.nih.gov/pubmed/15454437
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
Reactome	R-HSA-5576894	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576894
RefSeq	NP_004970	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004970
RefSeq	XP_011542212	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011542212
SMART	SM00225	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225
SMR	Q9NSA2	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9NSA2
STRING	9606.ENSP00000218176	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000218176&targetmode=cogs
SUPFAM	SSF54695	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54695
UCSC	uc004dlw	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004dlw&org=rat
UniGene	Hs.55276	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.55276
UniProtKB	KCND1_HUMAN	http://www.uniprot.org/uniprot/KCND1_HUMAN
UniProtKB-AC	Q9NSA2	http://www.uniprot.org/uniprot/Q9NSA2
charge	swissprot:KCND1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCND1_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG4390	http://eggnogapi.embl.de/nog_data/html/tree/KOG4390
epestfind	swissprot:KCND1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCND1_HUMAN
garnier	swissprot:KCND1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCND1_HUMAN
helixturnhelix	swissprot:KCND1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCND1_HUMAN
hmoment	swissprot:KCND1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCND1_HUMAN
iep	swissprot:KCND1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCND1_HUMAN
inforesidue	swissprot:KCND1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCND1_HUMAN
neXtProt	NX_Q9NSA2	http://www.nextprot.org/db/entry/NX_Q9NSA2
octanol	swissprot:KCND1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCND1_HUMAN
pepcoil	swissprot:KCND1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCND1_HUMAN
pepdigest	swissprot:KCND1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCND1_HUMAN
pepinfo	swissprot:KCND1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCND1_HUMAN
pepnet	swissprot:KCND1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCND1_HUMAN
pepstats	swissprot:KCND1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCND1_HUMAN
pepwheel	swissprot:KCND1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCND1_HUMAN
pepwindow	swissprot:KCND1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCND1_HUMAN
sigcleave	swissprot:KCND1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCND1_HUMAN
## Database	ID	URL or Descriptions
# DOMAIN	AQP11_HUMAN	Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). 
# Ensembl	ENST00000313578	ENSP00000318770; ENSG00000178301
# FUNCTION	AQP11_HUMAN	Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. {ECO 0000250}. 
# GO_component	GO:0005783	endoplasmic reticulum; IEA:Ensembl.
# GO_component	GO:0005829	cytosol; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0009986	cell surface; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0030425	dendrite; IEA:Ensembl.
# GO_function	GO:0015250	water channel activity; EXP:Reactome.
# GO_process	GO:0006833	water transport; TAS:Reactome.
# GO_process	GO:0048388	endosomal lumen acidification; IEA:Ensembl.
# GO_process	GO:0051260	protein homooligomerization; IEA:Ensembl.
# GO_process	GO:0072014	proximal tubule development; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# Gene3D	1.20.1080.10	-; 1.
# Genevisible	Q8NBQ7	HS
# HGNC	HGNC:19940	AQP11
# InterPro	IPR000425	MIP
# InterPro	IPR016697	Aquaporin_11/12
# InterPro	IPR023266	Aquaporin_11
# InterPro	IPR023271	Aquaporin-like
# KEGG_Brite	ko04040	Ion channels
# MIM	609914	gene
# Organism	AQP11_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR21191:SF7	PTHR21191:SF7
# PIRSF	PIRSF017529	Aquaporin_11/12
# PRINTS	PR00783	MINTRINSICP
# PRINTS	PR02024	AQUAPORIN11
# Pfam	PF00230	MIP
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-432047	Passive transport by Aquaporins
# RecName	AQP11_HUMAN	Aquaporin-11
# RefSeq	NP_766627	NM_173039.2
# SIMILARITY	Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	AQP11_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF81338	SSF81338
# TCDB	1.A.8.17	the major intrinsic protein (mip) family
# UCSC	uc001oyj	human
# eggNOG	ENOG410IHUS	Eukaryota
# eggNOG	ENOG4111GCP	LUCA
BLAST	swissprot:AQP11_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AQP11_HUMAN
BioCyc	ZFISH:ENSG00000178301-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000178301-MONOMER
COXPRESdb	282679	http://coxpresdb.jp/data/gene/282679.shtml
CleanEx	HS_AQP11	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AQP11
DOI	10.1093/dnares/12.2.117	http://dx.doi.org/10.1093/dnares/12.2.117
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB028147	http://www.ebi.ac.uk/ena/data/view/AB028147
EMBL	AK075346	http://www.ebi.ac.uk/ena/data/view/AK075346
EMBL	BC040443	http://www.ebi.ac.uk/ena/data/view/BC040443
Ensembl	ENST00000313578	http://www.ensembl.org/id/ENST00000313578
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_function	GO:0015250	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015250
GO_process	GO:0006833	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006833
GO_process	GO:0048388	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048388
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:0072014	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072014
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
Gene3D	1.20.1080.10	http://www.cathdb.info/version/latest/superfamily/1.20.1080.10
GeneCards	AQP11	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=AQP11
GeneID	282679	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=282679
GeneTree	ENSGT00530000063816	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063816
HGNC	HGNC:19940	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:19940
HOGENOM	HOG000034024	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000034024&db=HOGENOM6
HOVERGEN	HBG050556	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050556&db=HOVERGEN
HPA	HPA042879	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042879
InParanoid	Q8NBQ7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8NBQ7
IntAct	Q8NBQ7	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8NBQ7*
InterPro	IPR000425	http://www.ebi.ac.uk/interpro/entry/IPR000425
InterPro	IPR016697	http://www.ebi.ac.uk/interpro/entry/IPR016697
InterPro	IPR023266	http://www.ebi.ac.uk/interpro/entry/IPR023266
InterPro	IPR023271	http://www.ebi.ac.uk/interpro/entry/IPR023271
Jabion	282679	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=282679
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:282679	http://www.genome.jp/dbget-bin/www_bget?hsa:282679
KEGG_Orthology	KO:K09870	http://www.genome.jp/dbget-bin/www_bget?KO:K09870
MIM	609914	http://www.ncbi.nlm.nih.gov/omim/609914
OMA	CCTHELQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CCTHELQ
OrthoDB	EOG091G0JBQ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0JBQ
PANTHER	PTHR21191:SF7	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21191:SF7
PRINTS	PR00783	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00783
PRINTS	PR02024	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR02024
PSORT	swissprot:AQP11_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AQP11_HUMAN
PSORT-B	swissprot:AQP11_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AQP11_HUMAN
PSORT2	swissprot:AQP11_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AQP11_HUMAN
Pfam	PF00230	http://pfam.xfam.org/family/PF00230
PharmGKB	PA134949682	http://www.pharmgkb.org/do/serve?objId=PA134949682&objCls=Gene
Phobius	swissprot:AQP11_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AQP11_HUMAN
PhylomeDB	Q8NBQ7	http://phylomedb.org/?seqid=Q8NBQ7
ProteinModelPortal	Q8NBQ7	http://www.proteinmodelportal.org/query/uniprot/Q8NBQ7
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16303743	http://www.ncbi.nlm.nih.gov/pubmed/16303743
Reactome	R-HSA-432047	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432047
RefSeq	NP_766627	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_766627
STRING	9606.ENSP00000318770	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000318770&targetmode=cogs
SUPFAM	SSF81338	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81338
TCDB	1.A.8.17	http://www.tcdb.org/search/result.php?tc=1.A.8.17
UCSC	uc001oyj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001oyj&org=rat
UniGene	Hs.503345	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.503345
UniProtKB	AQP11_HUMAN	http://www.uniprot.org/uniprot/AQP11_HUMAN
UniProtKB-AC	Q8NBQ7	http://www.uniprot.org/uniprot/Q8NBQ7
charge	swissprot:AQP11_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AQP11_HUMAN
eggNOG	ENOG410IHUS	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IHUS
eggNOG	ENOG4111GCP	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111GCP
epestfind	swissprot:AQP11_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AQP11_HUMAN
garnier	swissprot:AQP11_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AQP11_HUMAN
helixturnhelix	swissprot:AQP11_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AQP11_HUMAN
hmoment	swissprot:AQP11_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AQP11_HUMAN
iep	swissprot:AQP11_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AQP11_HUMAN
inforesidue	swissprot:AQP11_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AQP11_HUMAN
neXtProt	NX_Q8NBQ7	http://www.nextprot.org/db/entry/NX_Q8NBQ7
octanol	swissprot:AQP11_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AQP11_HUMAN
pepcoil	swissprot:AQP11_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AQP11_HUMAN
pepdigest	swissprot:AQP11_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AQP11_HUMAN
pepinfo	swissprot:AQP11_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AQP11_HUMAN
pepnet	swissprot:AQP11_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AQP11_HUMAN
pepstats	swissprot:AQP11_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AQP11_HUMAN
pepwheel	swissprot:AQP11_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AQP11_HUMAN
pepwindow	swissprot:AQP11_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AQP11_HUMAN
sigcleave	swissprot:AQP11_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AQP11_HUMAN
## Database	ID	URL or Descriptions
# AltName	GRIK4_HUMAN	Excitatory amino acid receptor 1
# AltName	GRIK4_HUMAN	Glutamate receptor KA-1
# BioGrid	109157	2
# ChiTaRS	GRIK4	human
# Ensembl	ENST00000438375	ENSP00000404063; ENSG00000149403
# Ensembl	ENST00000527524	ENSP00000435648; ENSG00000149403
# FUNCTION	GRIK4_HUMAN	Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0032983	kainate selective glutamate receptor complex; IEA:Ensembl.
# GO_component	GO:0042734	presynaptic membrane; IEA:Ensembl.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0005234	extracellular-glutamate-gated ion channel activity; IEA:InterPro.
# GO_function	GO:0015276	ligand-gated ion channel activity; TAS:Reactome.
# GO_function	GO:0015277	kainate selective glutamate receptor activity; TAS:ProtInc.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007215	glutamate receptor signaling pathway; TAS:ProtInc.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# Genevisible	Q16099	HS
# HGNC	HGNC:4582	GRIK4
# InterPro	IPR001320	Iontro_rcpt
# InterPro	IPR001508	Iono_rcpt_met
# InterPro	IPR001828	ANF_lig-bd_rcpt
# InterPro	IPR019594	Glu/Gly-bd
# InterPro	IPR028082	Peripla_BP_I
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04724	Glutamatergic synapse
# MIM	600282	gene
# Organism	GRIK4_HUMAN	Homo sapiens (Human)
# PIR	JH0826	JH0826
# PRINTS	PR00177	NMDARECEPTOR
# Pfam	PF00060	Lig_chan
# Pfam	PF01094	ANF_receptor
# Pfam	PF10613	Lig_chan-Glu_bd
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-451308	Activation of Ca-permeable Kainate Receptor
# RecName	GRIK4_HUMAN	Glutamate receptor ionotropic, kainate 4
# RefSeq	NP_001269399	NM_001282470.2
# RefSeq	NP_055434	NM_014619.4
# SIMILARITY	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK4 subfamily. {ECO	0000305}.
# SMART	SM00079	PBPe
# SMART	SM00918	Lig_chan-Glu_bd
# SUBCELLULAR LOCATION	GRIK4_HUMAN	Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. 
# SUBUNIT	GRIK4_HUMAN	Forms a heteromeric channel with GRIK1 or GRIK3. 
# SUPFAM	SSF53822	SSF53822
# TCDB	1.A.10.1	the glutamate-gated ion channel (gic) family of neurotransmitter receptors
# UCSC	uc001pxn	human
# eggNOG	ENOG410KDI6	Eukaryota
# eggNOG	ENOG4110PNJ	LUCA
BLAST	swissprot:GRIK4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GRIK4_HUMAN
BioCyc	ZFISH:ENSG00000149403-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000149403-MONOMER
COXPRESdb	2900	http://coxpresdb.jp/data/gene/2900.shtml
CleanEx	HS_GRIK4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GRIK4
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
EMBL	AK292726	http://www.ebi.ac.uk/ena/data/view/AK292726
EMBL	CH471065	http://www.ebi.ac.uk/ena/data/view/CH471065
EMBL	S67803	http://www.ebi.ac.uk/ena/data/view/S67803
Ensembl	ENST00000438375	http://www.ensembl.org/id/ENST00000438375
Ensembl	ENST00000527524	http://www.ensembl.org/id/ENST00000527524
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0032983	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032983
GO_component	GO:0042734	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042734
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0005234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005234
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_function	GO:0015277	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015277
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007215
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GeneCards	GRIK4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GRIK4
GeneID	2900	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2900
GeneTree	ENSGT00760000118920	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118920
H-InvDB	HIX0036043	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0036043
HGNC	HGNC:4582	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4582
HOGENOM	HOG000234371	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234371&db=HOGENOM6
HOVERGEN	HBG051839	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051839&db=HOVERGEN
InParanoid	Q16099	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q16099
InterPro	IPR001320	http://www.ebi.ac.uk/interpro/entry/IPR001320
InterPro	IPR001508	http://www.ebi.ac.uk/interpro/entry/IPR001508
InterPro	IPR001828	http://www.ebi.ac.uk/interpro/entry/IPR001828
InterPro	IPR019594	http://www.ebi.ac.uk/interpro/entry/IPR019594
InterPro	IPR028082	http://www.ebi.ac.uk/interpro/entry/IPR028082
Jabion	2900	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2900
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:2900	http://www.genome.jp/dbget-bin/www_bget?hsa:2900
KEGG_Orthology	KO:K05204	http://www.genome.jp/dbget-bin/www_bget?KO:K05204
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
MIM	600282	http://www.ncbi.nlm.nih.gov/omim/600282
OMA	PAXVELE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PAXVELE
OrthoDB	EOG091G02LN	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02LN
PRINTS	PR00177	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00177
PSORT	swissprot:GRIK4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GRIK4_HUMAN
PSORT-B	swissprot:GRIK4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GRIK4_HUMAN
PSORT2	swissprot:GRIK4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GRIK4_HUMAN
Pfam	PF00060	http://pfam.xfam.org/family/PF00060
Pfam	PF01094	http://pfam.xfam.org/family/PF01094
Pfam	PF10613	http://pfam.xfam.org/family/PF10613
PharmGKB	PA28976	http://www.pharmgkb.org/do/serve?objId=PA28976&objCls=Gene
Phobius	swissprot:GRIK4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GRIK4_HUMAN
PhylomeDB	Q16099	http://phylomedb.org/?seqid=Q16099
ProteinModelPortal	Q16099	http://www.proteinmodelportal.org/query/uniprot/Q16099
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	8263508	http://www.ncbi.nlm.nih.gov/pubmed/8263508
Reactome	R-HSA-451308	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-451308
RefSeq	NP_001269399	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269399
RefSeq	NP_055434	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055434
SMART	SM00079	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00079
SMART	SM00918	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00918
SMR	Q16099	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q16099
STRING	9606.ENSP00000404063	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000404063&targetmode=cogs
SUPFAM	SSF53822	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822
TCDB	1.A.10.1	http://www.tcdb.org/search/result.php?tc=1.A.10.1
UCSC	uc001pxn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001pxn&org=rat
UniGene	Hs.538738	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.538738
UniGene	Hs.568901	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.568901
UniProtKB	GRIK4_HUMAN	http://www.uniprot.org/uniprot/GRIK4_HUMAN
UniProtKB-AC	Q16099	http://www.uniprot.org/uniprot/Q16099
charge	swissprot:GRIK4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GRIK4_HUMAN
eggNOG	ENOG410KDI6	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410KDI6
eggNOG	ENOG4110PNJ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110PNJ
epestfind	swissprot:GRIK4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GRIK4_HUMAN
garnier	swissprot:GRIK4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GRIK4_HUMAN
helixturnhelix	swissprot:GRIK4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GRIK4_HUMAN
hmoment	swissprot:GRIK4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GRIK4_HUMAN
iep	swissprot:GRIK4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GRIK4_HUMAN
inforesidue	swissprot:GRIK4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GRIK4_HUMAN
neXtProt	NX_Q16099	http://www.nextprot.org/db/entry/NX_Q16099
octanol	swissprot:GRIK4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GRIK4_HUMAN
pepcoil	swissprot:GRIK4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GRIK4_HUMAN
pepdigest	swissprot:GRIK4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GRIK4_HUMAN
pepinfo	swissprot:GRIK4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GRIK4_HUMAN
pepnet	swissprot:GRIK4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GRIK4_HUMAN
pepstats	swissprot:GRIK4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GRIK4_HUMAN
pepwheel	swissprot:GRIK4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GRIK4_HUMAN
pepwindow	swissprot:GRIK4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GRIK4_HUMAN
sigcleave	swissprot:GRIK4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GRIK4_HUMAN
## Database	ID	URL or Descriptions
# AltName	S40A1_HUMAN	Ferroportin-1
# AltName	S40A1_HUMAN	Iron-regulated transporter 1
# ChiTaRS	SLC40A1	human
# DISEASE	S40A1_HUMAN	Hemochromatosis 4 (HFE4) [MIM 606069]  A disorder of iron metabolism characterized by iron overload. Excess iron is deposited in a variety of organs leading to their failure, and resulting in serious illnesses including cirrhosis, hepatomas, diabetes, cardiomyopathy, arthritis, and hypogonadotropic hypogonadism. Severe effects of the disease usually do not appear until after decades of progressive iron loading. {ECO 0000269|PubMed 10747949, ECO 0000269|PubMed 11431687, ECO 0000269|PubMed 11518736, ECO 0000269|PubMed 12091366, ECO 0000269|PubMed 12091367, ECO 0000269|PubMed 12123233, ECO 0000269|PubMed 12406098, ECO 0000269|PubMed 12730114, ECO 0000269|PubMed 12857562, ECO 0000269|PubMed 12865285, ECO 0000269|PubMed 15338274, ECO 0000269|PubMed 15466004, ECO 0000269|PubMed 16351644}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000261024	ENSP00000261024; ENSG00000138449
# ExpressionAtlas	Q9NP59	baseline and differential
# FUNCTION	S40A1_HUMAN	May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). 
# GO_component	GO:0005622	intracellular; IDA:UniProtKB.
# GO_component	GO:0005737	cytoplasm; TAS:ProtInc.
# GO_component	GO:0005771	multivesicular body; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IC:BHF-UCL.
# GO_component	GO:0008021	synaptic vesicle; IEA:Ensembl.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_component	GO:0016323	basolateral plasma membrane; IDA:UniProtKB.
# GO_function	GO:0004872	receptor activity; ISS:BHF-UCL.
# GO_function	GO:0005381	iron ion transmembrane transporter activity; IMP:BHF-UCL.
# GO_function	GO:0015093	ferrous iron transmembrane transporter activity; ISS:BHF-UCL.
# GO_function	GO:0017046	peptide hormone binding; IPI:BHF-UCL.
# GO_function	GO:0097689	iron channel activity; ISS:BHF-UCL.
# GO_process	GO:0002260	lymphocyte homeostasis; IEA:Ensembl.
# GO_process	GO:0003158	endothelium development; IEA:Ensembl.
# GO_process	GO:0006879	cellular iron ion homeostasis; IMP:BHF-UCL.
# GO_process	GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron; IEA:Ensembl.
# GO_process	GO:0034755	iron ion transmembrane transport; IMP:BHF-UCL.
# GO_process	GO:0043066	negative regulation of apoptotic process; IEA:Ensembl.
# GO_process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
# GO_process	GO:0060345	spleen trabecula formation; IEA:Ensembl.
# GO_process	GO:0060586	multicellular organismal iron ion homeostasis; ISS:BHF-UCL.
# GO_process	GO:1903988	ferrous iron export; ISS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005622	intracellular
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048646	anatomical structure formation involved in morphogenesis
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9NP59	HS
# HGNC	HGNC:10909	SLC40A1
# INTERACTION	S40A1_HUMAN	P05067 APP; NbExp=5; IntAct=EBI-725153, EBI-77613; 
# IntAct	Q9NP59	5
# InterPro	IPR009716	Ferroportin-1
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H00211	[Inherited metabolic disease] Juvenile hemochromatosis (JH)
# KEGG_Pathway	ko04978	Mineral absorption
# MIM	604653	gene
# MIM	606069	phenotype
# Organism	S40A1_HUMAN	Homo sapiens (Human)
# Orphanet	139491	Hemochromatosis type 4
# Pfam	PF06963	FPN1
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-425410	Metal ion SLC transporters
# Reactome	R-HSA-917937	Iron uptake and transport
# RecName	S40A1_HUMAN	Solute carrier family 40 member 1
# RefSeq	NP_055400	NM_014585.5
# SIMILARITY	Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	S40A1_HUMAN	Cell membrane {ECO 0000269|PubMed 10882071, ECO 0000269|PubMed 23219802}; Multi-pass membrane protein {ECO 0000269|PubMed 10882071, ECO 0000269|PubMed 23219802}. Note=Localized to the basolateral membrane of polarized epithelial cells. 
# SUBUNIT	Identified in a complex with STOM. {ECO:0000269|PubMed	23219802}. 
# SUPFAM	SSF103473	SSF103473; 3
# TCDB	2.A.100.1	the ferroportin (fpn) family
# TISSUE SPECIFICITY	S40A1_HUMAN	Detected in erythrocytes (at protein level). Expressed in placenta, intestine, muscle and spleen. {ECO 0000269|PubMed 10747949, ECO 0000269|PubMed 23219802}. 
# UCSC	uc002uqp	human
# eggNOG	ENOG410XS3F	LUCA
# eggNOG	KOG2601	Eukaryota
BLAST	swissprot:S40A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S40A1_HUMAN
BioCyc	ZFISH:ENSG00000138449-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000138449-MONOMER
COXPRESdb	30061	http://coxpresdb.jp/data/gene/30061.shtml
CleanEx	HS_SLC40A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC40A1
DOI	10.1007/s00439-004-1166-y	http://dx.doi.org/10.1007/s00439-004-1166-y
DOI	10.1016/S0168-8278(03)00148-X	http://dx.doi.org/10.1016/S0168-8278(03)00148-X
DOI	10.1016/S1079-9796(03)00164-5	http://dx.doi.org/10.1016/S1079-9796(03)00164-5
DOI	10.1016/S1097-2765(00)80425-6	http://dx.doi.org/10.1016/S1097-2765(00)80425-6
DOI	10.1016/j.bbamem.2012.11.030	http://dx.doi.org/10.1016/j.bbamem.2012.11.030
DOI	10.1016/j.bcmd.2003.08.003	http://dx.doi.org/10.1016/j.bcmd.2003.08.003
DOI	10.1038/35001596	http://dx.doi.org/10.1038/35001596
DOI	10.1038/90038	http://dx.doi.org/10.1038/90038
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1046/j.1365-2141.2002.03946.x	http://dx.doi.org/10.1046/j.1365-2141.2002.03946.x
DOI	10.1074/jbc.M000713200	http://dx.doi.org/10.1074/jbc.M000713200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1101/gr.GR1547R	http://dx.doi.org/10.1101/gr.GR1547R
DOI	10.1111/j.1365-2141.2005.05815.x	http://dx.doi.org/10.1111/j.1365-2141.2005.05815.x
DOI	10.1136/gut.52.8.1215	http://dx.doi.org/10.1136/gut.52.8.1215
DOI	10.1136/jmg.2004.020644	http://dx.doi.org/10.1136/jmg.2004.020644
DOI	10.1172/JCI200113468	http://dx.doi.org/10.1172/JCI200113468
DOI	10.1182/blood-2001-11-0132	http://dx.doi.org/10.1182/blood-2001-11-0132
DOI	10.1182/blood-2002-03-0693	http://dx.doi.org/10.1182/blood-2002-03-0693
DOI	10.1182/blood-2003-02-0439	http://dx.doi.org/10.1182/blood-2003-02-0439
DOI	10.1182/blood.V100.2.692	http://dx.doi.org/10.1182/blood.V100.2.692
EMBL	AC013439	http://www.ebi.ac.uk/ena/data/view/AC013439
EMBL	AF171087	http://www.ebi.ac.uk/ena/data/view/AF171087
EMBL	AF215636	http://www.ebi.ac.uk/ena/data/view/AF215636
EMBL	AF226614	http://www.ebi.ac.uk/ena/data/view/AF226614
EMBL	AF231121	http://www.ebi.ac.uk/ena/data/view/AF231121
EMBL	AJ604512	http://www.ebi.ac.uk/ena/data/view/AJ604512
EMBL	AJ609539	http://www.ebi.ac.uk/ena/data/view/AJ609539
EMBL	AJ609540	http://www.ebi.ac.uk/ena/data/view/AJ609540
EMBL	AJ616847	http://www.ebi.ac.uk/ena/data/view/AJ616847
EMBL	AJ616848	http://www.ebi.ac.uk/ena/data/view/AJ616848
EMBL	AK314827	http://www.ebi.ac.uk/ena/data/view/AK314827
EMBL	AL136944	http://www.ebi.ac.uk/ena/data/view/AL136944
EMBL	BC035893	http://www.ebi.ac.uk/ena/data/view/BC035893
EMBL	BC037733	http://www.ebi.ac.uk/ena/data/view/BC037733
EMBL	CH471058	http://www.ebi.ac.uk/ena/data/view/CH471058
EMBL	CR533564	http://www.ebi.ac.uk/ena/data/view/CR533564
Ensembl	ENST00000261024	http://www.ensembl.org/id/ENST00000261024
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005771	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005771
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0008021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008021
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_function	GO:0004872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004872
GO_function	GO:0005381	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005381
GO_function	GO:0015093	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015093
GO_function	GO:0017046	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017046
GO_function	GO:0097689	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097689
GO_process	GO:0002260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002260
GO_process	GO:0003158	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003158
GO_process	GO:0006879	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006879
GO_process	GO:0034395	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034395
GO_process	GO:0034755	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034755
GO_process	GO:0043066	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043066
GO_process	GO:0045944	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045944
GO_process	GO:0060345	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060345
GO_process	GO:0060586	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060586
GO_process	GO:1903988	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903988
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048646	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048646
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC40A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC40A1
GeneID	30061	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=30061
GeneTree	ENSGT00390000015143	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000015143
HGNC	HGNC:10909	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10909
HOGENOM	HOG000234273	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234273&db=HOGENOM6
HOVERGEN	HBG055582	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG055582&db=HOVERGEN
HPA	HPA065634	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA065634
InParanoid	Q9NP59	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NP59
IntAct	Q9NP59	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NP59*
InterPro	IPR009716	http://www.ebi.ac.uk/interpro/entry/IPR009716
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	30061	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=30061
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00211	http://www.genome.jp/dbget-bin/www_bget?H00211
KEGG_Gene	hsa:30061	http://www.genome.jp/dbget-bin/www_bget?hsa:30061
KEGG_Orthology	KO:K14685	http://www.genome.jp/dbget-bin/www_bget?KO:K14685
KEGG_Pathway	ko04978	http://www.genome.jp/kegg-bin/show_pathway?ko04978
MIM	604653	http://www.ncbi.nlm.nih.gov/omim/604653
MIM	606069	http://www.ncbi.nlm.nih.gov/omim/606069
MINT	MINT-1404238	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1404238
OMA	CLTLCVI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CLTLCVI
Orphanet	139491	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=139491
OrthoDB	EOG091G06RI	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G06RI
PSORT	swissprot:S40A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S40A1_HUMAN
PSORT-B	swissprot:S40A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S40A1_HUMAN
PSORT2	swissprot:S40A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S40A1_HUMAN
Pfam	PF06963	http://pfam.xfam.org/family/PF06963
PharmGKB	PA35805	http://www.pharmgkb.org/do/serve?objId=PA35805&objCls=Gene
Phobius	swissprot:S40A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S40A1_HUMAN
PhylomeDB	Q9NP59	http://phylomedb.org/?seqid=Q9NP59
ProteinModelPortal	Q9NP59	http://www.proteinmodelportal.org/query/uniprot/Q9NP59
PubMed	10693807	http://www.ncbi.nlm.nih.gov/pubmed/10693807
PubMed	10747949	http://www.ncbi.nlm.nih.gov/pubmed/10747949
PubMed	10882071	http://www.ncbi.nlm.nih.gov/pubmed/10882071
PubMed	11230166	http://www.ncbi.nlm.nih.gov/pubmed/11230166
PubMed	11431687	http://www.ncbi.nlm.nih.gov/pubmed/11431687
PubMed	11518736	http://www.ncbi.nlm.nih.gov/pubmed/11518736
PubMed	12091366	http://www.ncbi.nlm.nih.gov/pubmed/12091366
PubMed	12091367	http://www.ncbi.nlm.nih.gov/pubmed/12091367
PubMed	12123233	http://www.ncbi.nlm.nih.gov/pubmed/12123233
PubMed	12406098	http://www.ncbi.nlm.nih.gov/pubmed/12406098
PubMed	12730114	http://www.ncbi.nlm.nih.gov/pubmed/12730114
PubMed	12857562	http://www.ncbi.nlm.nih.gov/pubmed/12857562
PubMed	12865285	http://www.ncbi.nlm.nih.gov/pubmed/12865285
PubMed	12873829	http://www.ncbi.nlm.nih.gov/pubmed/12873829
PubMed	14636642	http://www.ncbi.nlm.nih.gov/pubmed/14636642
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	14757427	http://www.ncbi.nlm.nih.gov/pubmed/14757427
PubMed	15338274	http://www.ncbi.nlm.nih.gov/pubmed/15338274
PubMed	15466004	http://www.ncbi.nlm.nih.gov/pubmed/15466004
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	16351644	http://www.ncbi.nlm.nih.gov/pubmed/16351644
PubMed	23219802	http://www.ncbi.nlm.nih.gov/pubmed/23219802
Reactome	R-HSA-425410	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425410
Reactome	R-HSA-917937	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917937
RefSeq	NP_055400	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055400
STRING	9606.ENSP00000261024	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000261024&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.100.1	http://www.tcdb.org/search/result.php?tc=2.A.100.1
UCSC	uc002uqp	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002uqp&org=rat
UniGene	Hs.643005	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.643005
UniProtKB	S40A1_HUMAN	http://www.uniprot.org/uniprot/S40A1_HUMAN
UniProtKB-AC	Q9NP59	http://www.uniprot.org/uniprot/Q9NP59
charge	swissprot:S40A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S40A1_HUMAN
eggNOG	ENOG410XS3F	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS3F
eggNOG	KOG2601	http://eggnogapi.embl.de/nog_data/html/tree/KOG2601
epestfind	swissprot:S40A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S40A1_HUMAN
garnier	swissprot:S40A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S40A1_HUMAN
helixturnhelix	swissprot:S40A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S40A1_HUMAN
hmoment	swissprot:S40A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S40A1_HUMAN
iep	swissprot:S40A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S40A1_HUMAN
inforesidue	swissprot:S40A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S40A1_HUMAN
neXtProt	NX_Q9NP59	http://www.nextprot.org/db/entry/NX_Q9NP59
octanol	swissprot:S40A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S40A1_HUMAN
pepcoil	swissprot:S40A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S40A1_HUMAN
pepdigest	swissprot:S40A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S40A1_HUMAN
pepinfo	swissprot:S40A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S40A1_HUMAN
pepnet	swissprot:S40A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S40A1_HUMAN
pepstats	swissprot:S40A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S40A1_HUMAN
pepwheel	swissprot:S40A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S40A1_HUMAN
pepwindow	swissprot:S40A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S40A1_HUMAN
sigcleave	swissprot:S40A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S40A1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ZACN_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q401N2-1; Sequence=Displayed; Name=2; IsoId=Q401N2-2; Sequence=VSP_030911, VSP_030912; Name=3; IsoId=Q401N2-3; Sequence=VSP_030909, VSP_030910; Note=No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 
# AltName	ZACN_HUMAN	Ligand-gated ion channel zinc-activated 1
# AltName	ZACN_HUMAN	Ligand-gated ion-channel receptor L2
# BioGrid	131658	70
# CAUTION	It is uncertain whether Met-1 or Met-2 is the initiator. {ECO	0000305}. 
# CCDS	CCDS11740	-. [Q401N2-1]
# ChiTaRS	ZACN	human
# Ensembl	ENST00000334586	ENSP00000334854; ENSG00000186919. [Q401N2-1]
# Ensembl	ENST00000421794	ENSP00000391936; ENSG00000186919. [Q401N2-3]
# Ensembl	ENST00000425015	ENSP00000397489; ENSG00000186919. [Q401N2-2]
# FUNCTION	ZACN_HUMAN	Zinc-activated ligand-gated ion channel. {ECO 0000269|PubMed 12381728}. 
# GO_component	GO:0005886	plasma membrane; IDA:HGNC.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0004993	G-protein coupled serotonin receptor activity; IBA:GO_Central.
# GO_function	GO:0005232	serotonin-activated cation-selective channel activity; IBA:GO_Central.
# GO_function	GO:0008270	zinc ion binding; IC:HGNC.
# GO_function	GO:0015276	ligand-gated ion channel activity; IDA:BHF-UCL.
# GO_process	GO:0007210	serotonin receptor signaling pathway; IBA:GO_Central.
# GO_process	GO:0010043	response to zinc ion; IDA:HGNC.
# GO_process	GO:0034220	ion transmembrane transport; IDA:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.370	-; 1.
# Gene3D	2.70.170.10	-; 1.
# Genevisible	Q401N2	HS
# HGNC	HGNC:29504	ZACN
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# InterPro	IPR027361	Acetylcholine_rcpt_TM
# MIM	610935	gene
# MISCELLANEOUS	ZACN_HUMAN	The mouse and rat orthologous proteins do not exist. 
# Organism	ZACN_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR18945	PTHR18945
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# PTM	ZACN_HUMAN	Glycosylated. {ECO 0000269|PubMed 16083862}. 
# Pfam	PF02931	Neur_chan_LBD
# Proteomes	UP000005640	Chromosome 17
# RecName	ZACN_HUMAN	Zinc-activated ligand-gated ion channel
# RefSeq	NP_851321	NM_180990.3. [Q401N2-1]
# SEQUENCE CAUTION	Sequence=AAI10598.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO20969.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305}; Sequence=EAW89365.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	ZACN_HUMAN	Cell membrane {ECO 0000269|PubMed 16083862}; Multi-pass membrane protein {ECO 0000269|PubMed 16083862}. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TCDB	1.A.9.11	the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family
# TISSUE SPECIFICITY	ZACN_HUMAN	Detected in pancreas, brain, liver, placenta, trachea, kidney, spinal cord, stomach and fetal brain. In the adult brain region expression is detected in the hippocampus, striatum, amygdala and thalamus. {ECO 0000269|PubMed 12381728, ECO 0000269|PubMed 16083862}. 
# TopDownProteomics	Q401N2-3	-. [Q401N2-3]
# UCSC	uc002jqn	human. [Q401N2-1]
# eggNOG	ENOG410IKFM	Eukaryota
# eggNOG	ENOG4111421	LUCA
BLAST	swissprot:ZACN_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ZACN_HUMAN
COXPRESdb	353174	http://coxpresdb.jp/data/gene/353174.shtml
CleanEx	HS_ZACN	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ZACN
DOI	10.1016/j.bbrc.2005.07.079	http://dx.doi.org/10.1016/j.bbrc.2005.07.079
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M208814200	http://dx.doi.org/10.1074/jbc.M208814200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB223030	http://www.ebi.ac.uk/ena/data/view/AB223030
EMBL	AC018665	http://www.ebi.ac.uk/ena/data/view/AC018665
EMBL	AF512521	http://www.ebi.ac.uk/ena/data/view/AF512521
EMBL	AK122638	http://www.ebi.ac.uk/ena/data/view/AK122638
EMBL	BC110596	http://www.ebi.ac.uk/ena/data/view/BC110596
EMBL	BC110597	http://www.ebi.ac.uk/ena/data/view/BC110597
EMBL	CH471099	http://www.ebi.ac.uk/ena/data/view/CH471099
EMBL	CH471099	http://www.ebi.ac.uk/ena/data/view/CH471099
Ensembl	ENST00000334586	http://www.ensembl.org/id/ENST00000334586
Ensembl	ENST00000421794	http://www.ensembl.org/id/ENST00000421794
Ensembl	ENST00000425015	http://www.ensembl.org/id/ENST00000425015
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0004993	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004993
GO_function	GO:0005232	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005232
GO_function	GO:0008270	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_process	GO:0007210	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007210
GO_process	GO:0010043	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010043
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.370	http://www.cathdb.info/version/latest/superfamily/1.20.120.370
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	ZACN	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ZACN
GeneID	353174	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=353174
GeneTree	ENSGT00790000122957	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00790000122957
H-InvDB	HIX0027141	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0027141
HGNC	HGNC:29504	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:29504
HOGENOM	HOG000155757	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000155757&db=HOGENOM6
HOVERGEN	HBG108756	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108756&db=HOVERGEN
InParanoid	Q401N2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q401N2
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
InterPro	IPR027361	http://www.ebi.ac.uk/interpro/entry/IPR027361
Jabion	353174	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=353174
KEGG_Gene	hsa:353174	http://www.genome.jp/dbget-bin/www_bget?hsa:353174
MIM	610935	http://www.ncbi.nlm.nih.gov/omim/610935
OMA	LVPCFQV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LVPCFQV
OrthoDB	EOG091G0CPT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0CPT
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:ZACN_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ZACN_HUMAN
PSORT-B	swissprot:ZACN_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ZACN_HUMAN
PSORT2	swissprot:ZACN_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ZACN_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
PharmGKB	PA162409377	http://www.pharmgkb.org/do/serve?objId=PA162409377&objCls=Gene
Phobius	swissprot:ZACN_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ZACN_HUMAN
PhylomeDB	Q401N2	http://phylomedb.org/?seqid=Q401N2
ProteinModelPortal	Q401N2	http://www.proteinmodelportal.org/query/uniprot/Q401N2
PubMed	12381728	http://www.ncbi.nlm.nih.gov/pubmed/12381728
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16083862	http://www.ncbi.nlm.nih.gov/pubmed/16083862
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
RefSeq	NP_851321	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_851321
STRING	9606.ENSP00000334854	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000334854&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TCDB	1.A.9.11	http://www.tcdb.org/search/result.php?tc=1.A.9.11
UCSC	uc002jqn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002jqn&org=rat
UniGene	Hs.714919	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.714919
UniProtKB	ZACN_HUMAN	http://www.uniprot.org/uniprot/ZACN_HUMAN
UniProtKB-AC	Q401N2	http://www.uniprot.org/uniprot/Q401N2
charge	swissprot:ZACN_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ZACN_HUMAN
eggNOG	ENOG410IKFM	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IKFM
eggNOG	ENOG4111421	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111421
epestfind	swissprot:ZACN_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ZACN_HUMAN
garnier	swissprot:ZACN_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ZACN_HUMAN
helixturnhelix	swissprot:ZACN_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZACN_HUMAN
hmoment	swissprot:ZACN_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ZACN_HUMAN
iep	swissprot:ZACN_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ZACN_HUMAN
inforesidue	swissprot:ZACN_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ZACN_HUMAN
neXtProt	NX_Q401N2	http://www.nextprot.org/db/entry/NX_Q401N2
octanol	swissprot:ZACN_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ZACN_HUMAN
pepcoil	swissprot:ZACN_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ZACN_HUMAN
pepdigest	swissprot:ZACN_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ZACN_HUMAN
pepinfo	swissprot:ZACN_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ZACN_HUMAN
pepnet	swissprot:ZACN_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ZACN_HUMAN
pepstats	swissprot:ZACN_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ZACN_HUMAN
pepwheel	swissprot:ZACN_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ZACN_HUMAN
pepwindow	swissprot:ZACN_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ZACN_HUMAN
sigcleave	swissprot:ZACN_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ZACN_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S12A3_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P55017-1; Sequence=Displayed; Name=2; IsoId=P55017-2; Sequence=VSP_036318; Name=3; IsoId=P55017-3; Sequence=VSP_040100, VSP_036318; Note=No experimental confirmation available.; 
# AltName	S12A3_HUMAN	Na-Cl cotransporter
# AltName	S12A3_HUMAN	Na-Cl symporter
# AltName	S12A3_HUMAN	Thiazide-sensitive sodium-chloride cotransporter
# BioGrid	112448	11
# CCDS	CCDS10770	-. [P55017-2]
# CCDS	CCDS45491	-. [P55017-3]
# CCDS	CCDS58464	-. [P55017-1]
# ChiTaRS	SLC12A3	human
# DISEASE	S12A3_HUMAN	Gitelman syndrome (GTLMNS) [MIM 263800]  An autosomal recessive disorder characterized by hypokalemic alkalosis in combination with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. Patients are often asymptomatic or present transient periods of muscular weakness and tetany, usually accompanied by abdominal pain, vomiting and fever. The phenotype is highly heterogeneous in terms of age at onset and severity. Cardinal features such as hypocalciuria and hypomagnesemia might also change during the life cycle of a given patient. It has overlapping features with Bartter syndrome. {ECO 0000269|PubMed 10616841, ECO 0000269|PubMed 10988270, ECO 0000269|PubMed 11168953, ECO 0000269|PubMed 11940055, ECO 0000269|PubMed 12008755, ECO 0000269|PubMed 12112667, ECO 0000269|PubMed 15069170, ECO 0000269|PubMed 15687331, ECO 0000269|PubMed 16429844, ECO 0000269|PubMed 17654016, ECO 0000269|PubMed 17873326, ECO 0000269|PubMed 22009145, ECO 0000269|PubMed 8528245, ECO 0000269|PubMed 8900229, ECO 0000269|PubMed 8954067, ECO 0000269|PubMed 9734597}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00436	Bendroflumethiazide
# DrugBank	DB00524	Metolazone
# DrugBank	DB00562	Benzthiazide
# DrugBank	DB00880	Chlorothiazide
# DrugBank	DB00999	Hydrochlorothiazide
# DrugBank	DB01119	Diazoxide
# DrugBank	DB01324	Polythiazide
# DrugBank	DB01325	Quinethazone
# ENZYME REGULATION	Activated by WNK3. {ECO:0000269|PubMed	21613606}. 
# Ensembl	ENST00000438926	ENSP00000402152; ENSG00000070915. [P55017-2]
# Ensembl	ENST00000563236	ENSP00000456149; ENSG00000070915. [P55017-1]
# Ensembl	ENST00000566786	ENSP00000457552; ENSG00000070915. [P55017-3]
# ExpressionAtlas	P55017	baseline and differential
# FUNCTION	S12A3_HUMAN	Electroneutral sodium and chloride ion cotransporter. In kidney distal convoluted tubules, key mediator of sodium and chloride reabsorption (PubMed 21613606, PubMed 22009145). Receptor for the proinflammatory cytokine IL18. Contributes to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2. May act either independently of IL18R1, or in a complex with IL18R1 (By similarity). {ECO 0000250|UniProtKB P59158, ECO 0000269|PubMed 21613606, ECO 0000269|PubMed 22009145}. 
# GO_component	GO:0005829	cytosol; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0016324	apical plasma membrane; ISS:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005215	transporter activity; ISS:UniProtKB.
# GO_function	S12A3_HUMAN	GO 0015378 sodium chloride symporter activity; TAS Reactome.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006814	sodium ion transport; ISS:UniProtKB.
# GO_process	GO:0035725	sodium ion transmembrane transport; ISS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P55017	HS
# HGNC	HGNC:10912	SLC12A3
# InterPro	IPR002948	SLC12A3
# InterPro	IPR004841	AA-permease/SLC12A_dom
# InterPro	IPR004842	SLC12A_fam
# InterPro	IPR013612	AA_permease_N
# InterPro	IPR018491	SLC12_C
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H00240	[Endocrine disease; Urinary system disease] Gitelman syndrome
# MIM	263800	phenotype
# MIM	600968	gene
# MISCELLANEOUS	Target of thiazide diuretics used in the treatment of high blood pressure. {ECO:0000305|PubMed	8528245}. 
# Organism	S12A3_HUMAN	Homo sapiens (Human)
# Orphanet	358	Gitelman syndrome
# PANTHER	PTHR11827:SF9	PTHR11827:SF9; 3
# PIR	G01202	G01202
# PIR	PC4180	PC4180
# PRINTS	PR01230	NACLTRNSPORT
# PTM	S12A3_HUMAN	Phosphorylated in response to IL18. {ECO 0000250|UniProtKB P59158}. 
# PTM	S12A3_HUMAN	Ubiquitinated; ubiquitination is essential for regulation of endocytosis. The BCR(KLHL3) complex was initially identified as a candidate ubiquitin ligase for SLC12A3 (PubMed 22406640). However, it was later shown that it is not the case. {ECO 0000269|PubMed 22406640}. 
# Pfam	PF00324	AA_permease
# Pfam	PF03522	SLC12; 2
# Pfam	PF08403	AA_permease_N
# Proteomes	UP000005640	Chromosome 16
# Reactome	R-HSA-426117	Cation-coupled Chloride cotransporters
# RecName	S12A3_HUMAN	Solute carrier family 12 member 3
# RefSeq	NP_000330	NM_000339.2
# RefSeq	NP_001119579	NM_001126107.1
# RefSeq	NP_001119580	NM_001126108.1
# SIMILARITY	Belongs to the SLC12A transporter family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S12A3_HUMAN	Cell membrane {ECO 0000269|PubMed 22009145}; Multi-pass membrane protein. 
# SUBUNIT	S12A3_HUMAN	Interacts with KLHL3 (PubMed 22406640). Interacts with IL18R1; this interaction is increased by IL18 treatment (By similarity). {ECO 0000250|UniProtKB P59158, ECO 0000269|PubMed 22406640}. 
# TCDB	2.A.30.4	the cation-chloride cotransporter (ccc) family
# TIGRFAMs	TIGR00930	2a30
# TISSUE SPECIFICITY	S12A3_HUMAN	Predominantly expressed in kidney (PubMed 8812482). Not detected in normal aorta, but abundantly expressed in fatty streaks and advanced atherosclerotic lesions (at protein level) (PubMed 26099046). {ECO 0000269|PubMed 26099046, ECO 0000269|PubMed 8812482}. 
# UCSC	uc002ekd	human. [P55017-1]
# eggNOG	COG0531	LUCA
# eggNOG	KOG2083	Eukaryota
BLAST	swissprot:S12A3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S12A3_HUMAN
BioCyc	ZFISH:ENSG00000070915-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000070915-MONOMER
COXPRESdb	6559	http://coxpresdb.jp/data/gene/6559.shtml
CleanEx	HS_SLC12A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC12A3
DOI	10.1002/humu.9045	http://dx.doi.org/10.1002/humu.9045
DOI	10.1006/geno.1996.0388	http://dx.doi.org/10.1006/geno.1996.0388
DOI	10.1007/s12020-007-0024-9	http://dx.doi.org/10.1007/s12020-007-0024-9
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/ejhg.2011.189	http://dx.doi.org/10.1038/ejhg.2011.189
DOI	10.1038/nature03187	http://dx.doi.org/10.1038/nature03187
DOI	10.1038/ng.2218	http://dx.doi.org/10.1038/ng.2218
DOI	10.1038/ng0196-24	http://dx.doi.org/10.1038/ng0196-24
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/nm.3890	http://dx.doi.org/10.1038/nm.3890
DOI	10.1046/j.1365-2265.2002.01223.x	http://dx.doi.org/10.1046/j.1365-2265.2002.01223.x
DOI	10.1046/j.1523-1755.1998.00070.x	http://dx.doi.org/10.1046/j.1523-1755.1998.00070.x
DOI	10.1046/j.1523-1755.2001.059002710.x	http://dx.doi.org/10.1046/j.1523-1755.2001.059002710.x
DOI	10.1080/10425170701400456	http://dx.doi.org/10.1080/10425170701400456
DOI	10.1093/ndt/gfh239	http://dx.doi.org/10.1093/ndt/gfh239
DOI	10.1097/HJH.0b013e3282a9be1b	http://dx.doi.org/10.1097/HJH.0b013e3282a9be1b
DOI	10.1152/ajpcell.00070.2011	http://dx.doi.org/10.1152/ajpcell.00070.2011
DOI	10.1161/01.HYP.36.3.389	http://dx.doi.org/10.1161/01.HYP.36.3.389
DOI	10.1210/jc.2004-1905	http://dx.doi.org/10.1210/jc.2004-1905
DOI	10.1210/jc.81.12.4496	http://dx.doi.org/10.1210/jc.81.12.4496
DOI	10.1507/endocrj.49.91	http://dx.doi.org/10.1507/endocrj.49.91
DrugBank	DB00436	http://www.drugbank.ca/drugs/DB00436
DrugBank	DB00524	http://www.drugbank.ca/drugs/DB00524
DrugBank	DB00562	http://www.drugbank.ca/drugs/DB00562
DrugBank	DB00880	http://www.drugbank.ca/drugs/DB00880
DrugBank	DB00999	http://www.drugbank.ca/drugs/DB00999
DrugBank	DB01119	http://www.drugbank.ca/drugs/DB01119
DrugBank	DB01324	http://www.drugbank.ca/drugs/DB01324
DrugBank	DB01325	http://www.drugbank.ca/drugs/DB01325
EMBL	AC012181	http://www.ebi.ac.uk/ena/data/view/AC012181
EMBL	AK315298	http://www.ebi.ac.uk/ena/data/view/AK315298
EMBL	U44128	http://www.ebi.ac.uk/ena/data/view/U44128
EMBL	X91220	http://www.ebi.ac.uk/ena/data/view/X91220
Ensembl	ENST00000438926	http://www.ensembl.org/id/ENST00000438926
Ensembl	ENST00000563236	http://www.ensembl.org/id/ENST00000563236
Ensembl	ENST00000566786	http://www.ensembl.org/id/ENST00000566786
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0015378	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015378
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0035725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035725
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC12A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC12A3
GeneID	6559	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6559
GeneTree	ENSGT00760000119053	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119053
HGNC	HGNC:10912	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10912
HOGENOM	HOG000062855	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000062855&db=HOGENOM6
HOVERGEN	HBG052851	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052851&db=HOVERGEN
HPA	HPA028748	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA028748
InParanoid	P55017	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P55017
InterPro	IPR002948	http://www.ebi.ac.uk/interpro/entry/IPR002948
InterPro	IPR004841	http://www.ebi.ac.uk/interpro/entry/IPR004841
InterPro	IPR004842	http://www.ebi.ac.uk/interpro/entry/IPR004842
InterPro	IPR013612	http://www.ebi.ac.uk/interpro/entry/IPR013612
InterPro	IPR018491	http://www.ebi.ac.uk/interpro/entry/IPR018491
Jabion	6559	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6559
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00240	http://www.genome.jp/dbget-bin/www_bget?H00240
KEGG_Gene	hsa:6559	http://www.genome.jp/dbget-bin/www_bget?hsa:6559
KEGG_Orthology	KO:K14426	http://www.genome.jp/dbget-bin/www_bget?KO:K14426
MIM	263800	http://www.ncbi.nlm.nih.gov/omim/263800
MIM	600968	http://www.ncbi.nlm.nih.gov/omim/600968
OMA	GPRKQRM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GPRKQRM
Orphanet	358	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=358
OrthoDB	EOG091G04G2	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G04G2
PANTHER	PTHR11827:SF9	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11827:SF9
PRINTS	PR01230	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01230
PSORT	swissprot:S12A3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S12A3_HUMAN
PSORT-B	swissprot:S12A3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S12A3_HUMAN
PSORT2	swissprot:S12A3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S12A3_HUMAN
Pfam	PF00324	http://pfam.xfam.org/family/PF00324
Pfam	PF03522	http://pfam.xfam.org/family/PF03522
Pfam	PF08403	http://pfam.xfam.org/family/PF08403
PharmGKB	PA321	http://www.pharmgkb.org/do/serve?objId=PA321&objCls=Gene
Phobius	swissprot:S12A3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S12A3_HUMAN
PhylomeDB	P55017	http://phylomedb.org/?seqid=P55017
ProteinModelPortal	P55017	http://www.proteinmodelportal.org/query/uniprot/P55017
PubMed	10616841	http://www.ncbi.nlm.nih.gov/pubmed/10616841
PubMed	10988270	http://www.ncbi.nlm.nih.gov/pubmed/10988270
PubMed	11168953	http://www.ncbi.nlm.nih.gov/pubmed/11168953
PubMed	11940055	http://www.ncbi.nlm.nih.gov/pubmed/11940055
PubMed	12008755	http://www.ncbi.nlm.nih.gov/pubmed/12008755
PubMed	12112667	http://www.ncbi.nlm.nih.gov/pubmed/12112667
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15069170	http://www.ncbi.nlm.nih.gov/pubmed/15069170
PubMed	15616553	http://www.ncbi.nlm.nih.gov/pubmed/15616553
PubMed	15687331	http://www.ncbi.nlm.nih.gov/pubmed/15687331
PubMed	16429844	http://www.ncbi.nlm.nih.gov/pubmed/16429844
PubMed	17654016	http://www.ncbi.nlm.nih.gov/pubmed/17654016
PubMed	17873326	http://www.ncbi.nlm.nih.gov/pubmed/17873326
PubMed	17885550	http://www.ncbi.nlm.nih.gov/pubmed/17885550
PubMed	21613606	http://www.ncbi.nlm.nih.gov/pubmed/21613606
PubMed	22009145	http://www.ncbi.nlm.nih.gov/pubmed/22009145
PubMed	22406640	http://www.ncbi.nlm.nih.gov/pubmed/22406640
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	26099046	http://www.ncbi.nlm.nih.gov/pubmed/26099046
PubMed	8528245	http://www.ncbi.nlm.nih.gov/pubmed/8528245
PubMed	8812482	http://www.ncbi.nlm.nih.gov/pubmed/8812482
PubMed	8900229	http://www.ncbi.nlm.nih.gov/pubmed/8900229
PubMed	8954067	http://www.ncbi.nlm.nih.gov/pubmed/8954067
PubMed	9734597	http://www.ncbi.nlm.nih.gov/pubmed/9734597
Reactome	R-HSA-426117	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-426117
RefSeq	NP_000330	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000330
RefSeq	NP_001119579	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001119579
RefSeq	NP_001119580	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001119580
STRING	9606.ENSP00000402152	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000402152&targetmode=cogs
TCDB	2.A.30.4	http://www.tcdb.org/search/result.php?tc=2.A.30.4
TIGRFAMs	TIGR00930	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00930
UCSC	uc002ekd	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ekd&org=rat
UniGene	Hs.669115	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.669115
UniProtKB	S12A3_HUMAN	http://www.uniprot.org/uniprot/S12A3_HUMAN
UniProtKB-AC	P55017	http://www.uniprot.org/uniprot/P55017
charge	swissprot:S12A3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S12A3_HUMAN
eggNOG	COG0531	http://eggnogapi.embl.de/nog_data/html/tree/COG0531
eggNOG	KOG2083	http://eggnogapi.embl.de/nog_data/html/tree/KOG2083
epestfind	swissprot:S12A3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S12A3_HUMAN
garnier	swissprot:S12A3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S12A3_HUMAN
helixturnhelix	swissprot:S12A3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S12A3_HUMAN
hmoment	swissprot:S12A3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S12A3_HUMAN
iep	swissprot:S12A3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S12A3_HUMAN
inforesidue	swissprot:S12A3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S12A3_HUMAN
neXtProt	NX_P55017	http://www.nextprot.org/db/entry/NX_P55017
octanol	swissprot:S12A3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S12A3_HUMAN
pepcoil	swissprot:S12A3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S12A3_HUMAN
pepdigest	swissprot:S12A3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S12A3_HUMAN
pepinfo	swissprot:S12A3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S12A3_HUMAN
pepnet	swissprot:S12A3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S12A3_HUMAN
pepstats	swissprot:S12A3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S12A3_HUMAN
pepwheel	swissprot:S12A3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S12A3_HUMAN
pepwindow	swissprot:S12A3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S12A3_HUMAN
sigcleave	swissprot:S12A3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S12A3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S17A9_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9BYT1-1; Sequence=Displayed; Name=2; IsoId=Q9BYT1-2; Sequence=VSP_010344; Name=3; IsoId=Q9BYT1-3; Sequence=VSP_010345, VSP_010346; Note=No experimental confirmation available.; 
# CCDS	CCDS42901	-. [Q9BYT1-1]
# CCDS	CCDS77600	-. [Q9BYT1-2]
# CDD	cd06174	MFS
# DISEASE	S17A9_HUMAN	Porokeratosis 8, disseminated superficial actinic type (POROK8) [MIM 616063]  A form of porokeratosis, a disorder of faulty keratinization characterized by one or more atrophic patches surrounded by a distinctive hyperkeratotic ridgelike border called the cornoid lamella. The keratotic lesions can progress to overt cutaneous neoplasms, typically squamous cell carcinomas. Multiple clinical variants of porokeratosis are recognized, including porokeratosis of Mibelli, linear porokeratosis, disseminated superficial actinic porokeratosis, palmoplantar porokeratosis, and punctate porokeratosis. Disseminated superficial actinic porokeratosis (DSAP) is the most common subtype. It is characterized by multiple small, annular, anhidrotic, keratotic lesions that are located predominantly on sun-exposed areas of the skin, such as the face, neck, and distal limbs. The lesions typically begin to develop in adolescence and reach near-complete penetrance by the third or fourth decade of life. {ECO 0000269|PubMed 25180256}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000370349	ENSP00000359374; ENSG00000101194. [Q9BYT1-2]
# Ensembl	ENST00000370351	ENSP00000359376; ENSG00000101194. [Q9BYT1-1]
# ExpressionAtlas	Q9BYT1	baseline and differential
# FUNCTION	S17A9_HUMAN	Involved in vesicular storage and exocytosis of ATP. May accumulate ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. {ECO 0000269|PubMed 18375752}. 
# GO_component	GO:0016021	integral component of membrane; IBA:GO_Central.
# GO_function	GO:0022857	transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0006820	anion transport; IBA:GO_Central.
# GO_process	GO:0006887	exocytosis; IEA:UniProtKB-KW.
# GO_process	GO:0055085	transmembrane transport; IBA:GO_Central.
# GO_process	GO:1903146	regulation of mitophagy; IMP:ParkinsonsUK-UCL.
# GO_process	GO:1903955	positive regulation of protein targeting to mitochondrion; IMP:ParkinsonsUK-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9BYT1	HS
# HGNC	HGNC:16192	SLC17A9
# InterPro	IPR005829	Sugar_transporter_CS
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	612107	gene
# MIM	616063	phenotype
# Organism	S17A9_HUMAN	Homo sapiens (Human)
# Orphanet	79152	Disseminated superficial actinic porokeratosis
# PROSITE	PS00217	SUGAR_TRANSPORT_2
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 20
# RecName	S17A9_HUMAN	Solute carrier family 17 member 9
# RefSeq	NP_001289572	NM_001302643.1
# RefSeq	NP_071365	NM_022082.3
# SEQUENCE CAUTION	Sequence=AAH25312.1; Type=Erroneous termination; Positions=389; Note=Translated as Leu.; Evidence={ECO:0000305}; Sequence=BAB84933.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S17A9_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.14.21	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	Predominantly expressed in adrenal gland, brain and thyroid. {ECO:0000269|PubMed	18375752}. 
# UCSC	uc002ydz	human. [Q9BYT1-1]
# eggNOG	ENOG410IRU8	Eukaryota
# eggNOG	ENOG411038V	LUCA
BLAST	swissprot:S17A9_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S17A9_HUMAN
BioCyc	ZFISH:ENSG00000101194-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000101194-MONOMER
COXPRESdb	63910	http://coxpresdb.jp/data/gene/63910.shtml
DOI	10.1038/414865a	http://dx.doi.org/10.1038/414865a
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0800141105	http://dx.doi.org/10.1073/pnas.0800141105
DOI	10.1093/dnares/10.1.49	http://dx.doi.org/10.1093/dnares/10.1.49
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1136/jmedgenet-2014-102486	http://dx.doi.org/10.1136/jmedgenet-2014-102486
EMBL	AK074107	http://www.ebi.ac.uk/ena/data/view/AK074107
EMBL	AK095473	http://www.ebi.ac.uk/ena/data/view/AK095473
EMBL	AL121673	http://www.ebi.ac.uk/ena/data/view/AL121673
EMBL	AL121673	http://www.ebi.ac.uk/ena/data/view/AL121673
EMBL	BC025312	http://www.ebi.ac.uk/ena/data/view/BC025312
EMBL	BC027447	http://www.ebi.ac.uk/ena/data/view/BC027447
EMBL	BC038593	http://www.ebi.ac.uk/ena/data/view/BC038593
Ensembl	ENST00000370349	http://www.ensembl.org/id/ENST00000370349
Ensembl	ENST00000370351	http://www.ensembl.org/id/ENST00000370351
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GO_process	GO:0006820	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006820
GO_process	GO:0006887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006887
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GO_process	GO:1903146	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903146
GO_process	GO:1903955	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903955
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC17A9	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC17A9
GeneID	63910	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=63910
GeneTree	ENSGT00760000119079	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119079
HGNC	HGNC:16192	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16192
HPA	HPA047470	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA047470
HPA	HPA056499	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA056499
InParanoid	Q9BYT1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9BYT1
IntAct	Q9BYT1	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9BYT1*
InterPro	IPR005829	http://www.ebi.ac.uk/interpro/entry/IPR005829
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	63910	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=63910
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:63910	http://www.genome.jp/dbget-bin/www_bget?hsa:63910
KEGG_Orthology	KO:K12303	http://www.genome.jp/dbget-bin/www_bget?KO:K12303
MIM	612107	http://www.ncbi.nlm.nih.gov/omim/612107
MIM	616063	http://www.ncbi.nlm.nih.gov/omim/616063
OMA	LLDWCGW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LLDWCGW
Orphanet	79152	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=79152
OrthoDB	EOG091G077E	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G077E
PROSITE	PS00217	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00217
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:S17A9_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S17A9_HUMAN
PSORT-B	swissprot:S17A9_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S17A9_HUMAN
PSORT2	swissprot:S17A9_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S17A9_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA164725806	http://www.pharmgkb.org/do/serve?objId=PA164725806&objCls=Gene
Phobius	swissprot:S17A9_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S17A9_HUMAN
PhylomeDB	Q9BYT1	http://phylomedb.org/?seqid=Q9BYT1
ProteinModelPortal	Q9BYT1	http://www.proteinmodelportal.org/query/uniprot/Q9BYT1
PubMed	11780052	http://www.ncbi.nlm.nih.gov/pubmed/11780052
PubMed	12693554	http://www.ncbi.nlm.nih.gov/pubmed/12693554
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18375752	http://www.ncbi.nlm.nih.gov/pubmed/18375752
PubMed	25180256	http://www.ncbi.nlm.nih.gov/pubmed/25180256
RefSeq	NP_001289572	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001289572
RefSeq	NP_071365	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_071365
STRING	9606.ENSP00000359376	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000359376&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.14.21	http://www.tcdb.org/search/result.php?tc=2.A.1.14.21
UCSC	uc002ydz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ydz&org=rat
UniGene	Hs.512686	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.512686
UniProtKB	S17A9_HUMAN	http://www.uniprot.org/uniprot/S17A9_HUMAN
UniProtKB-AC	Q9BYT1	http://www.uniprot.org/uniprot/Q9BYT1
charge	swissprot:S17A9_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S17A9_HUMAN
eggNOG	ENOG410IRU8	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IRU8
eggNOG	ENOG411038V	http://eggnogapi.embl.de/nog_data/html/tree/ENOG411038V
epestfind	swissprot:S17A9_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S17A9_HUMAN
garnier	swissprot:S17A9_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S17A9_HUMAN
helixturnhelix	swissprot:S17A9_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S17A9_HUMAN
hmoment	swissprot:S17A9_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S17A9_HUMAN
iep	swissprot:S17A9_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S17A9_HUMAN
inforesidue	swissprot:S17A9_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S17A9_HUMAN
neXtProt	NX_Q9BYT1	http://www.nextprot.org/db/entry/NX_Q9BYT1
octanol	swissprot:S17A9_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S17A9_HUMAN
pepcoil	swissprot:S17A9_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S17A9_HUMAN
pepdigest	swissprot:S17A9_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S17A9_HUMAN
pepinfo	swissprot:S17A9_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S17A9_HUMAN
pepnet	swissprot:S17A9_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S17A9_HUMAN
pepstats	swissprot:S17A9_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S17A9_HUMAN
pepwheel	swissprot:S17A9_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S17A9_HUMAN
pepwindow	swissprot:S17A9_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S17A9_HUMAN
sigcleave	swissprot:S17A9_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S17A9_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TRPC7_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9HCX4-1; Sequence=Displayed; Name=2; IsoId=Q9HCX4-2; Sequence=VSP_043035; Note=No experimental confirmation available.; Name=3; IsoId=Q9HCX4-3; Sequence=VSP_044897; Note=No experimental confirmation available.; 
# AltName	TRPC7_HUMAN	Transient receptor protein 7
# BioGrid	121378	4
# CCDS	CCDS47267	-. [Q9HCX4-1]
# CCDS	CCDS54905	-. [Q9HCX4-2]
# CCDS	CCDS54906	-. [Q9HCX4-3]
# ChiTaRS	TRPC7	human
# Ensembl	ENST00000352189	ENSP00000330322; ENSG00000069018. [Q9HCX4-2]
# Ensembl	ENST00000378459	ENSP00000367720; ENSG00000069018. [Q9HCX4-3]
# Ensembl	ENST00000513104	ENSP00000426070; ENSG00000069018. [Q9HCX4-1]
# ExpressionAtlas	Q9HCX4	baseline and differential
# FUNCTION	TRPC7_HUMAN	Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion. {ECO 0000250}. 
# GO_component	GO:0005635	nuclear envelope; IEA:UniProtKB-SubCell.
# GO_component	GO:0005801	cis-Golgi network; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IEA:Ensembl.
# GO_function	GO:0005262	calcium channel activity; TAS:Reactome.
# GO_function	GO:0015279	store-operated calcium channel activity; IBA:GO_Central.
# GO_process	GO:0006828	manganese ion transport; IBA:GO_Central.
# GO_process	GO:0007338	single fertilization; IBA:GO_Central.
# GO_process	GO:0030168	platelet activation; TAS:Reactome.
# GO_process	GO:0051480	regulation of cytosolic calcium ion concentration; IBA:GO_Central.
# GO_process	GO:0070588	calcium ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005635	nuclear envelope
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.25.40.20	-; 1.
# Genevisible	Q9HCX4	HS
# HGNC	HGNC:20754	TRPC7
# InterPro	IPR002110	Ankyrin_rpt
# InterPro	IPR002153	TRPC_channel
# InterPro	IPR004729	TRP_channel
# InterPro	IPR005463	TRPC7_channel
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR013555	TRP_dom
# InterPro	IPR020683	Ankyrin_rpt-contain_dom
# KEGG_Brite	ko04040	Ion channels
# Organism	TRPC7_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10117	PTHR10117
# PANTHER	PTHR10117:SF9	PTHR10117:SF9
# PRINTS	PR01097	TRNSRECEPTRP
# PRINTS	PR01648	TRPCHANNEL7
# PTM	TRPC7_HUMAN	Phosphorylation by PRKG1 at Thr-15 negatively regulates TRPC7 activity. {ECO 0000269|PubMed 21402151}. 
# Pfam	PF00520	Ion_trans
# Pfam	PF08344	TRP_2
# Pfam	PF12796	Ank_2
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-114508	Effects of PIP2 hydrolysis
# Reactome	R-HSA-139853	Elevation of cytosolic Ca2+ levels
# Reactome	R-HSA-3295583	TRP channels
# Reactome	R-HSA-418890	Role of second messengers in netrin-1 signaling
# RecName	TRPC7_HUMAN	Short transient receptor potential channel 7
# RefSeq	NP_001161048	NM_001167576.1. [Q9HCX4-2]
# RefSeq	NP_001161049	NM_001167577.1. [Q9HCX4-3]
# RefSeq	NP_065122	NM_020389.2. [Q9HCX4-1]
# SIMILARITY	Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC7 sub-subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 4 ANK repeats. {ECO	0000305}.
# SMART	SM00248	ANK; 3
# SUBCELLULAR LOCATION	TRPC7_HUMAN	Cell membrane {ECO 0000269|PubMed 21402151}; Multi-pass membrane protein {ECO 0000269|PubMed 21402151}. Nucleus envelope {ECO 0000269|PubMed 21402151}. 
# SUBUNIT	TRPC7_HUMAN	Interacts with MX1 and RNF24. Interacts (via ANK-repeat domains) with PRKG1. {ECO 0000269|PubMed 15757897, ECO 0000269|PubMed 17850865, ECO 0000269|PubMed 21402151}. 
# SUPFAM	SSF48403	SSF48403
# TIGRFAMs	TIGR00870	trp
# UCSC	uc003lbn	human. [Q9HCX4-1]
# eggNOG	ENOG410XQ0Y	LUCA
# eggNOG	KOG3609	Eukaryota
BLAST	swissprot:TRPC7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TRPC7_HUMAN
BioCyc	ZFISH:ENSG00000069018-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000069018-MONOMER
COXPRESdb	57113	http://coxpresdb.jp/data/gene/57113.shtml
CleanEx	HS_TRPC7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TRPC7
DOI	10.1016/j.ceca.2007.07.009	http://dx.doi.org/10.1016/j.ceca.2007.07.009
DOI	10.1016/j.cellsig.2011.03.005	http://dx.doi.org/10.1016/j.cellsig.2011.03.005
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1074/jbc.M500391200	http://dx.doi.org/10.1074/jbc.M500391200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC008661	http://www.ebi.ac.uk/ena/data/view/AC008661
EMBL	AJ272034	http://www.ebi.ac.uk/ena/data/view/AJ272034
EMBL	AJ549088	http://www.ebi.ac.uk/ena/data/view/AJ549088
EMBL	AY167927	http://www.ebi.ac.uk/ena/data/view/AY167927
EMBL	BC128185	http://www.ebi.ac.uk/ena/data/view/BC128185
Ensembl	ENST00000352189	http://www.ensembl.org/id/ENST00000352189
Ensembl	ENST00000378459	http://www.ensembl.org/id/ENST00000378459
Ensembl	ENST00000513104	http://www.ensembl.org/id/ENST00000513104
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GO_component	GO:0005801	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005801
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0015279	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015279
GO_process	GO:0006828	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006828
GO_process	GO:0007338	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007338
GO_process	GO:0030168	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030168
GO_process	GO:0051480	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051480
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.25.40.20	http://www.cathdb.info/version/latest/superfamily/1.25.40.20
GeneCards	TRPC7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TRPC7
GeneID	57113	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57113
GeneTree	ENSGT00760000119180	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119180
HGNC	HGNC:20754	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20754
HOGENOM	HOG000020590	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000020590&db=HOGENOM6
HOVERGEN	HBG068337	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG068337&db=HOVERGEN
HPA	CAB022592	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB022592
HPA	HPA031126	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031126
InParanoid	Q9HCX4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9HCX4
IntAct	Q9HCX4	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9HCX4*
InterPro	IPR002110	http://www.ebi.ac.uk/interpro/entry/IPR002110
InterPro	IPR002153	http://www.ebi.ac.uk/interpro/entry/IPR002153
InterPro	IPR004729	http://www.ebi.ac.uk/interpro/entry/IPR004729
InterPro	IPR005463	http://www.ebi.ac.uk/interpro/entry/IPR005463
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR013555	http://www.ebi.ac.uk/interpro/entry/IPR013555
InterPro	IPR020683	http://www.ebi.ac.uk/interpro/entry/IPR020683
Jabion	57113	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=57113
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:57113	http://www.genome.jp/dbget-bin/www_bget?hsa:57113
KEGG_Orthology	KO:K04970	http://www.genome.jp/dbget-bin/www_bget?KO:K04970
OMA	GSNTFKN	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GSNTFKN
OrthoDB	EOG091G01FB	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01FB
PANTHER	PTHR10117	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10117
PANTHER	PTHR10117:SF9	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10117:SF9
PRINTS	PR01097	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01097
PRINTS	PR01648	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01648
PSORT	swissprot:TRPC7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TRPC7_HUMAN
PSORT-B	swissprot:TRPC7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TRPC7_HUMAN
PSORT2	swissprot:TRPC7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TRPC7_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF08344	http://pfam.xfam.org/family/PF08344
Pfam	PF12796	http://pfam.xfam.org/family/PF12796
PharmGKB	PA164742693	http://www.pharmgkb.org/do/serve?objId=PA164742693&objCls=Gene
Phobius	swissprot:TRPC7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TRPC7_HUMAN
PhylomeDB	Q9HCX4	http://phylomedb.org/?seqid=Q9HCX4
ProteinModelPortal	Q9HCX4	http://www.proteinmodelportal.org/query/uniprot/Q9HCX4
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15757897	http://www.ncbi.nlm.nih.gov/pubmed/15757897
PubMed	17850865	http://www.ncbi.nlm.nih.gov/pubmed/17850865
PubMed	21402151	http://www.ncbi.nlm.nih.gov/pubmed/21402151
Reactome	R-HSA-114508	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-114508
Reactome	R-HSA-139853	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-139853
Reactome	R-HSA-3295583	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3295583
Reactome	R-HSA-418890	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418890
RefSeq	NP_001161048	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001161048
RefSeq	NP_001161049	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001161049
RefSeq	NP_065122	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_065122
SMART	SM00248	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00248
STRING	9606.ENSP00000426070	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000426070&targetmode=cogs
SUPFAM	SSF48403	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48403
TIGRFAMs	TIGR00870	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00870
UCSC	uc003lbn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003lbn&org=rat
UniGene	Hs.591263	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.591263
UniProtKB	TRPC7_HUMAN	http://www.uniprot.org/uniprot/TRPC7_HUMAN
UniProtKB-AC	Q9HCX4	http://www.uniprot.org/uniprot/Q9HCX4
charge	swissprot:TRPC7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TRPC7_HUMAN
eggNOG	ENOG410XQ0Y	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ0Y
eggNOG	KOG3609	http://eggnogapi.embl.de/nog_data/html/tree/KOG3609
epestfind	swissprot:TRPC7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TRPC7_HUMAN
garnier	swissprot:TRPC7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TRPC7_HUMAN
helixturnhelix	swissprot:TRPC7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRPC7_HUMAN
hmoment	swissprot:TRPC7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TRPC7_HUMAN
iep	swissprot:TRPC7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TRPC7_HUMAN
inforesidue	swissprot:TRPC7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TRPC7_HUMAN
neXtProt	NX_Q9HCX4	http://www.nextprot.org/db/entry/NX_Q9HCX4
octanol	swissprot:TRPC7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TRPC7_HUMAN
pepcoil	swissprot:TRPC7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TRPC7_HUMAN
pepdigest	swissprot:TRPC7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TRPC7_HUMAN
pepinfo	swissprot:TRPC7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TRPC7_HUMAN
pepnet	swissprot:TRPC7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TRPC7_HUMAN
pepstats	swissprot:TRPC7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TRPC7_HUMAN
pepwheel	swissprot:TRPC7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TRPC7_HUMAN
pepwindow	swissprot:TRPC7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TRPC7_HUMAN
sigcleave	swissprot:TRPC7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TRPC7_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	NPT1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14916-1; Sequence=Displayed; Name=2; IsoId=Q14916-2; Sequence=VSP_035012; Note=No experimental confirmation available.; 
# AltName	NPT1_HUMAN	Na(+)/PI cotransporter 1
# AltName	NPT1_HUMAN	Na/Pi-4
# AltName	NPT1_HUMAN	Renal Na(+)-dependent phosphate cotransporter 1
# AltName	NPT1_HUMAN	Renal sodium-dependent phosphate transport protein 1
# AltName	NPT1_HUMAN	Sodium/phosphate cotransporter 1
# AltName	NPT1_HUMAN	Solute carrier family 17 member 1
# BioGrid	112456	2
# CAUTION	It is uncertain whether Met-1 or Met-3 is the initiator. {ECO	0000305}. 
# CCDS	CCDS4565	-. [Q14916-1]
# CDD	cd06174	MFS
# Ensembl	ENST00000244527	ENSP00000244527; ENSG00000124568. [Q14916-1]
# Ensembl	ENST00000468082	ENSP00000420546; ENSG00000124568. [Q14916-2]
# Ensembl	ENST00000476801	ENSP00000420614; ENSG00000124568. [Q14916-1]
# ExpressionAtlas	Q14916	baseline and differential
# FUNCTION	NPT1_HUMAN	Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_function	GO:0015321	sodium-dependent phosphate transmembrane transporter activity; TAS:Reactome.
# GO_function	NPT1_HUMAN	GO 0005436 sodium phosphate symporter activity; IBA GO_Central.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006817	phosphate ion transport; TAS:ProtInc.
# GO_process	GO:0035725	sodium ion transmembrane transport; IBA:GO_Central.
# GO_process	GO:0046415	urate metabolic process; IMP:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q14916	HS
# HGNC	HGNC:10929	SLC17A1
# InterPro	IPR004745	Pi_cotranspt
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	182308	gene
# Organism	NPT1_HUMAN	Homo sapiens (Human)
# PIR	A48916	A48916
# PIR	I39473	I39473
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-428643	Organic anion transporters
# RecName	NPT1_HUMAN	Sodium-dependent phosphate transport protein 1
# RefSeq	NP_005065	NM_005074.3. [Q14916-1]
# SEQUENCE CAUTION	Sequence=BAA05888.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI19543.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	NPT1_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Interacts with PDZK1. {ECO	0000250}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.14.27	the major facilitator superfamily (mfs)
# TIGRFAMs	TIGR00894	2A0114euk
# TISSUE SPECIFICITY	NPT1_HUMAN	Expressed in kidney cortex, liver and brain but not in other tissues. 
# UCSC	uc003nfh	human. [Q14916-1]
# eggNOG	ENOG410XPWC	LUCA
# eggNOG	KOG2532	Eukaryota
BLAST	swissprot:NPT1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NPT1_HUMAN
BioCyc	ZFISH:ENSG00000124568-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000124568-MONOMER
COXPRESdb	6568	http://coxpresdb.jp/data/gene/6568.shtml
CleanEx	HS_SLC17A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC17A1
DOI	10.1006/geno.1993.1476	http://dx.doi.org/10.1006/geno.1993.1476
DOI	10.1016/S0167-4781(97)00231-5	http://dx.doi.org/10.1016/S0167-4781(97)00231-5
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/bj3050081	http://dx.doi.org/10.1042/bj3050081
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF362490	http://www.ebi.ac.uk/ena/data/view/AF362490
EMBL	AF362492	http://www.ebi.ac.uk/ena/data/view/AF362492
EMBL	AF362494	http://www.ebi.ac.uk/ena/data/view/AF362494
EMBL	AK290783	http://www.ebi.ac.uk/ena/data/view/AK290783
EMBL	AL138726	http://www.ebi.ac.uk/ena/data/view/AL138726
EMBL	AY780791	http://www.ebi.ac.uk/ena/data/view/AY780791
EMBL	BC101745	http://www.ebi.ac.uk/ena/data/view/BC101745
EMBL	BC101747	http://www.ebi.ac.uk/ena/data/view/BC101747
EMBL	CH471087	http://www.ebi.ac.uk/ena/data/view/CH471087
EMBL	D28532	http://www.ebi.ac.uk/ena/data/view/D28532
EMBL	D83236	http://www.ebi.ac.uk/ena/data/view/D83236
EMBL	X71355	http://www.ebi.ac.uk/ena/data/view/X71355
Ensembl	ENST00000244527	http://www.ensembl.org/id/ENST00000244527
Ensembl	ENST00000468082	http://www.ensembl.org/id/ENST00000468082
Ensembl	ENST00000476801	http://www.ensembl.org/id/ENST00000476801
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0005436	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005436
GO_function	GO:0015321	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015321
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006817	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006817
GO_process	GO:0035725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035725
GO_process	GO:0046415	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046415
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC17A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC17A1
GeneID	6568	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6568
GeneTree	ENSGT00760000119079	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119079
HGNC	HGNC:10929	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10929
HOVERGEN	HBG008834	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG008834&db=HOVERGEN
InParanoid	Q14916	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q14916
InterPro	IPR004745	http://www.ebi.ac.uk/interpro/entry/IPR004745
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	6568	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6568
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6568	http://www.genome.jp/dbget-bin/www_bget?hsa:6568
KEGG_Orthology	KO:K12300	http://www.genome.jp/dbget-bin/www_bget?KO:K12300
MIM	182308	http://www.ncbi.nlm.nih.gov/omim/182308
OMA	CLNLTMV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CLNLTMV
OrthoDB	EOG091G08YP	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08YP
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:NPT1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NPT1_HUMAN
PSORT-B	swissprot:NPT1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NPT1_HUMAN
PSORT2	swissprot:NPT1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NPT1_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA35820	http://www.pharmgkb.org/do/serve?objId=PA35820&objCls=Gene
Phobius	swissprot:NPT1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NPT1_HUMAN
PhylomeDB	Q14916	http://phylomedb.org/?seqid=Q14916
ProteinModelPortal	Q14916	http://www.proteinmodelportal.org/query/uniprot/Q14916
PubMed	11704559	http://www.ncbi.nlm.nih.gov/pubmed/11704559
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	7826357	http://www.ncbi.nlm.nih.gov/pubmed/7826357
PubMed	8288239	http://www.ncbi.nlm.nih.gov/pubmed/8288239
PubMed	9545579	http://www.ncbi.nlm.nih.gov/pubmed/9545579
Reactome	R-HSA-428643	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428643
RefSeq	NP_005065	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005065
STRING	9606.ENSP00000244527	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000244527&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.14.27	http://www.tcdb.org/search/result.php?tc=2.A.1.14.27
TIGRFAMs	TIGR00894	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00894
UCSC	uc003nfh	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003nfh&org=rat
UniGene	Hs.205816	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.205816
UniProtKB	NPT1_HUMAN	http://www.uniprot.org/uniprot/NPT1_HUMAN
UniProtKB-AC	Q14916	http://www.uniprot.org/uniprot/Q14916
charge	swissprot:NPT1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NPT1_HUMAN
eggNOG	ENOG410XPWC	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPWC
eggNOG	KOG2532	http://eggnogapi.embl.de/nog_data/html/tree/KOG2532
epestfind	swissprot:NPT1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NPT1_HUMAN
garnier	swissprot:NPT1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NPT1_HUMAN
helixturnhelix	swissprot:NPT1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NPT1_HUMAN
hmoment	swissprot:NPT1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NPT1_HUMAN
iep	swissprot:NPT1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NPT1_HUMAN
inforesidue	swissprot:NPT1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NPT1_HUMAN
neXtProt	NX_Q14916	http://www.nextprot.org/db/entry/NX_Q14916
octanol	swissprot:NPT1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NPT1_HUMAN
pepcoil	swissprot:NPT1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NPT1_HUMAN
pepdigest	swissprot:NPT1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NPT1_HUMAN
pepinfo	swissprot:NPT1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NPT1_HUMAN
pepnet	swissprot:NPT1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NPT1_HUMAN
pepstats	swissprot:NPT1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NPT1_HUMAN
pepwheel	swissprot:NPT1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NPT1_HUMAN
pepwindow	swissprot:NPT1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NPT1_HUMAN
sigcleave	swissprot:NPT1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NPT1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ABCB7_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O75027-1; Sequence=Displayed; Name=2; IsoId=O75027-2; Sequence=VSP_014635; Name=3; IsoId=O75027-3; Sequence=VSP_054700; Note=No experimental confirmation available. Gene prediction based on EST data.; 
# AltName	ABCB7_HUMAN	ATP-binding cassette transporter 7
# BioGrid	106540	27
# CCDS	CCDS14428	-. [O75027-2]
# CCDS	CCDS65290	-. [O75027-3]
# CCDS	CCDS65291	-. [O75027-1]
# ChiTaRS	ABCB7	human
# DISEASE	ABCB7_HUMAN	Anemia, sideroblastic, spinocerebellar ataxia (ASAT) [MIM 301310]  A X-linked recessive disorder characterized by an infantile to early childhood onset of non-progressive cerebellar ataxia and mild anemia, with hypochromia and microcytosis. {ECO 0000269|PubMed 10196363, ECO 0000269|PubMed 11050011, ECO 0000269|PubMed 11843825, ECO 0000269|PubMed 22398176}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000253577	ENSP00000253577; ENSG00000131269. [O75027-2]
# Ensembl	ENST00000339447	ENSP00000343849; ENSG00000131269. [O75027-3]
# Ensembl	ENST00000373394	ENSP00000362492; ENSG00000131269. [O75027-1]
# ExpressionAtlas	O75027	baseline and differential
# FUNCTION	ABCB7_HUMAN	Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins. 
# GO_component	GO:0005739	mitochondrion; IDA:HPA.
# GO_component	GO:0005743	mitochondrial inner membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IBA:GO_Central.
# GO_function	GO:0005524	ATP binding; TAS:ProtInc.
# GO_function	GO:0015232	heme transporter activity; TAS:Reactome.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; TAS:ProtInc.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006879	cellular iron ion homeostasis; IBA:GO_Central.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 1.
# Genevisible	O75027	HS
# HGNC	HGNC:48	ABCB7
# IntAct	O75027	5
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR011527	ABC1_TM_dom
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Disease	H00982	[Hematologic disease] X-linked sideroblastic anemia with ataxia (ASAT)
# KEGG_Pathway	ko02010	ABC transporters
# MIM	300135	gene
# MIM	301310	phenotype
# Organism	ABCB7_HUMAN	Homo sapiens (Human)
# Orphanet	2802	X-linked sideroblastic anemia with ataxia
# PROSITE	PS00211	ABC_TRANSPORTER_1
# PROSITE	PS50893	ABC_TRANSPORTER_2
# PROSITE	PS50929	ABC_TM1F
# Pfam	PF00005	ABC_tran
# Pfam	PF00664	ABC_membrane
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-1369007	Mitochondrial ABC transporters
# Reactome	R-HSA-2564830	Cytosolic iron-sulfur cluster assembly
# RecName	ABCB7_HUMAN	ATP-binding cassette sub-family B member 7, mitochondrial
# RefSeq	NP_001258625	NM_001271696.1. [O75027-1]
# RefSeq	NP_001258626	NM_001271697.1. [O75027-3]
# RefSeq	NP_001258627	NM_001271698.1
# RefSeq	NP_004290	NM_004299.4. [O75027-2]
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule	PRU00441}. 
# SIMILARITY	Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA
# SUBCELLULAR LOCATION	ABCB7_HUMAN	Mitochondrion inner membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000255|PROSITE- ProRule PRU00441}. 
# SUBUNIT	Homodimer or heterodimer. {ECO	0000305}. 
# SUPFAM	SSF52540	SSF52540
# SUPFAM	SSF90123	SSF90123
# TCDB	3.A.1.210	the atp-binding cassette (abc) superfamily
# UCSC	uc004ebz	human. [O75027-1]
# WEB RESOURCE	ABCB7_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=O75027";
# eggNOG	COG5265	LUCA
# eggNOG	KOG0057	Eukaryota
BLAST	swissprot:ABCB7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCB7_HUMAN
BioCyc	ZFISH:HS05510-MONOMER	http://biocyc.org/getid?id=ZFISH:HS05510-MONOMER
COXPRESdb	22	http://coxpresdb.jp/data/gene/22.shtml
CleanEx	HS_ABCB7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCB7
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1007/s100380050051	http://dx.doi.org/10.1007/s100380050051
DOI	10.1016/S0014-5793(98)01560-9	http://dx.doi.org/10.1016/S0014-5793(98)01560-9
DOI	10.1016/j.ejpn.2012.02.003	http://dx.doi.org/10.1016/j.ejpn.2012.02.003
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1046/j.1365-2141.2001.03015.x	http://dx.doi.org/10.1046/j.1365-2141.2001.03015.x
DOI	10.1073/pnas.95.14.8175	http://dx.doi.org/10.1073/pnas.95.14.8175
DOI	10.1093/hmg/8.5.743	http://dx.doi.org/10.1093/hmg/8.5.743
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AB005289	http://www.ebi.ac.uk/ena/data/view/AB005289
EMBL	AF038950	http://www.ebi.ac.uk/ena/data/view/AF038950
EMBL	AF078777	http://www.ebi.ac.uk/ena/data/view/AF078777
EMBL	AF133659	http://www.ebi.ac.uk/ena/data/view/AF133659
EMBL	AF241872	http://www.ebi.ac.uk/ena/data/view/AF241872
EMBL	AF241873	http://www.ebi.ac.uk/ena/data/view/AF241873
EMBL	AF241874	http://www.ebi.ac.uk/ena/data/view/AF241874
EMBL	AF241875	http://www.ebi.ac.uk/ena/data/view/AF241875
EMBL	AF241876	http://www.ebi.ac.uk/ena/data/view/AF241876
EMBL	AF241877	http://www.ebi.ac.uk/ena/data/view/AF241877
EMBL	AF241878	http://www.ebi.ac.uk/ena/data/view/AF241878
EMBL	AF241879	http://www.ebi.ac.uk/ena/data/view/AF241879
EMBL	AF241880	http://www.ebi.ac.uk/ena/data/view/AF241880
EMBL	AF241881	http://www.ebi.ac.uk/ena/data/view/AF241881
EMBL	AF241882	http://www.ebi.ac.uk/ena/data/view/AF241882
EMBL	AF241883	http://www.ebi.ac.uk/ena/data/view/AF241883
EMBL	AF241884	http://www.ebi.ac.uk/ena/data/view/AF241884
EMBL	AF241885	http://www.ebi.ac.uk/ena/data/view/AF241885
EMBL	AF241886	http://www.ebi.ac.uk/ena/data/view/AF241886
EMBL	AF241887	http://www.ebi.ac.uk/ena/data/view/AF241887
EMBL	AL359545	http://www.ebi.ac.uk/ena/data/view/AL359545
EMBL	AL359545	http://www.ebi.ac.uk/ena/data/view/AL359545
EMBL	AL359545	http://www.ebi.ac.uk/ena/data/view/AL359545
EMBL	AL359545	http://www.ebi.ac.uk/ena/data/view/AL359545
EMBL	AL360179	http://www.ebi.ac.uk/ena/data/view/AL360179
EMBL	AL360179	http://www.ebi.ac.uk/ena/data/view/AL360179
EMBL	AL360179	http://www.ebi.ac.uk/ena/data/view/AL360179
EMBL	AL360179	http://www.ebi.ac.uk/ena/data/view/AL360179
EMBL	BC006323	http://www.ebi.ac.uk/ena/data/view/BC006323
EMBL	BT009918	http://www.ebi.ac.uk/ena/data/view/BT009918
EMBL	CH471104	http://www.ebi.ac.uk/ena/data/view/CH471104
Ensembl	ENST00000253577	http://www.ensembl.org/id/ENST00000253577
Ensembl	ENST00000339447	http://www.ensembl.org/id/ENST00000339447
Ensembl	ENST00000373394	http://www.ensembl.org/id/ENST00000373394
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0015232	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015232
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006879	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006879
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCB7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCB7
GeneID	22	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22
GeneTree	ENSGT00440000033373	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00440000033373
H-InvDB	HIX0028475	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0028475
HGNC	HGNC:48	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:48
HOVERGEN	HBG080194	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG080194&db=HOVERGEN
HPA	HPA034982	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA034982
InParanoid	O75027	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O75027
IntAct	O75027	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O75027*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR011527	http://www.ebi.ac.uk/interpro/entry/IPR011527
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	22	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=22
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Disease	H00982	http://www.genome.jp/dbget-bin/www_bget?H00982
KEGG_Gene	hsa:22	http://www.genome.jp/dbget-bin/www_bget?hsa:22
KEGG_Orthology	KO:K05662	http://www.genome.jp/dbget-bin/www_bget?KO:K05662
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
MIM	300135	http://www.ncbi.nlm.nih.gov/omim/300135
MIM	301310	http://www.ncbi.nlm.nih.gov/omim/301310
OMA	MMYLAAN	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MMYLAAN
Orphanet	2802	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=2802
OrthoDB	EOG091G02G4	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02G4
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PROSITE	PS50929	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929
PSORT	swissprot:ABCB7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCB7_HUMAN
PSORT-B	swissprot:ABCB7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCB7_HUMAN
PSORT2	swissprot:ABCB7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCB7_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF00664	http://pfam.xfam.org/family/PF00664
PharmGKB	PA24389	http://www.pharmgkb.org/do/serve?objId=PA24389&objCls=Gene
Phobius	swissprot:ABCB7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCB7_HUMAN
PhylomeDB	O75027	http://phylomedb.org/?seqid=O75027
ProteinModelPortal	O75027	http://www.proteinmodelportal.org/query/uniprot/O75027
PubMed	10196363	http://www.ncbi.nlm.nih.gov/pubmed/10196363
PubMed	11050011	http://www.ncbi.nlm.nih.gov/pubmed/11050011
PubMed	11843825	http://www.ncbi.nlm.nih.gov/pubmed/11843825
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22398176	http://www.ncbi.nlm.nih.gov/pubmed/22398176
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	9621516	http://www.ncbi.nlm.nih.gov/pubmed/9621516
PubMed	9653160	http://www.ncbi.nlm.nih.gov/pubmed/9653160
PubMed	9883897	http://www.ncbi.nlm.nih.gov/pubmed/9883897
Reactome	R-HSA-1369007	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1369007
Reactome	R-HSA-2564830	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2564830
RefSeq	NP_001258625	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001258625
RefSeq	NP_001258626	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001258626
RefSeq	NP_001258627	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001258627
RefSeq	NP_004290	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004290
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	O75027	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O75027
STRING	9606.ENSP00000253577	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000253577&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
SUPFAM	SSF90123	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123
TCDB	3.A.1.210	http://www.tcdb.org/search/result.php?tc=3.A.1.210
UCSC	uc004ebz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004ebz&org=rat
UniGene	Hs.370480	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.370480
UniProtKB	ABCB7_HUMAN	http://www.uniprot.org/uniprot/ABCB7_HUMAN
UniProtKB-AC	O75027	http://www.uniprot.org/uniprot/O75027
charge	swissprot:ABCB7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCB7_HUMAN
eggNOG	COG5265	http://eggnogapi.embl.de/nog_data/html/tree/COG5265
eggNOG	KOG0057	http://eggnogapi.embl.de/nog_data/html/tree/KOG0057
epestfind	swissprot:ABCB7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCB7_HUMAN
garnier	swissprot:ABCB7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCB7_HUMAN
helixturnhelix	swissprot:ABCB7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCB7_HUMAN
hmoment	swissprot:ABCB7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCB7_HUMAN
iep	swissprot:ABCB7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCB7_HUMAN
inforesidue	swissprot:ABCB7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCB7_HUMAN
neXtProt	NX_O75027	http://www.nextprot.org/db/entry/NX_O75027
octanol	swissprot:ABCB7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCB7_HUMAN
pepcoil	swissprot:ABCB7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCB7_HUMAN
pepdigest	swissprot:ABCB7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCB7_HUMAN
pepinfo	swissprot:ABCB7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCB7_HUMAN
pepnet	swissprot:ABCB7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCB7_HUMAN
pepstats	swissprot:ABCB7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCB7_HUMAN
pepwheel	swissprot:ABCB7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCB7_HUMAN
pepwindow	swissprot:ABCB7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCB7_HUMAN
sigcleave	swissprot:ABCB7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCB7_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	VGLU1_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9P2U7-1; Sequence=Displayed; Name=2; IsoId=Q9P2U7-2; Sequence=VSP_056110; Note=No experimental confirmation available.; Name=3; IsoId=Q9P2U7-3; Sequence=VSP_056111; Note=No experimental confirmation available.; 
# AltName	VGLU1_HUMAN	Brain-specific Na(+)-dependent inorganic phosphate cotransporter
# AltName	VGLU1_HUMAN	Solute carrier family 17 member 7
# CCDS	CCDS12764	-. [Q9P2U7-1]
# CDD	cd06174	MFS
# ChiTaRS	SLC17A7	human
# Ensembl	ENST00000221485	ENSP00000221485; ENSG00000104888. [Q9P2U7-1]
# Ensembl	ENST00000600601	ENSP00000470338; ENSG00000104888. [Q9P2U7-2]
# ExpressionAtlas	Q9P2U7	baseline and differential
# FUNCTION	VGLU1_HUMAN	Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. {ECO 0000269|PubMed 10820226}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IDA:MGI.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030672	synaptic vesicle membrane; IBA:GO_Central.
# GO_component	GO:0044300	cerebellar mossy fiber; IEA:Ensembl.
# GO_component	GO:0048786	presynaptic active zone; IEA:Ensembl.
# GO_component	GO:0060076	excitatory synapse; IEA:Ensembl.
# GO_component	GO:0060203	clathrin-sculpted glutamate transport vesicle membrane; TAS:Reactome.
# GO_component	GO:0098794	postsynapse; IEA:GOC.
# GO_function	GO:0005313	L-glutamate transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0005315	inorganic phosphate transmembrane transporter activity; IEA:Ensembl.
# GO_function	GO:0008068	extracellular-glutamate-gated chloride channel activity; IEA:Ensembl.
# GO_function	GO:0015321	sodium-dependent phosphate transmembrane transporter activity; TAS:ProtInc.
# GO_function	VGLU1_HUMAN	GO 0015319 sodium inorganic phosphate symporter activity; IDA MGI.
# GO_process	GO:0003407	neural retina development; IEA:Ensembl.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006817	phosphate ion transport; TAS:ProtInc.
# GO_process	GO:0006836	neurotransmitter transport; IEA:UniProtKB-KW.
# GO_process	GO:0007420	brain development; IEA:Ensembl.
# GO_process	GO:0007616	long-term memory; IEA:Ensembl.
# GO_process	GO:0014047	glutamate secretion; TAS:Reactome.
# GO_process	GO:0035249	synaptic transmission, glutamatergic; IEA:Ensembl.
# GO_process	GO:0042137	sequestering of neurotransmitter; IEA:Ensembl.
# GO_process	GO:0051938	L-glutamate import; IEA:Ensembl.
# GO_process	GO:0060079	excitatory postsynaptic potential; IEA:Ensembl.
# GO_process	GO:0097401	synaptic vesicle lumen acidification; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# Genevisible	Q9P2U7	HS
# HGNC	HGNC:16704	SLC17A7
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04724	Glutamatergic synapse
# KEGG_Pathway	ko05033	Nicotine addiction
# MIM	605208	gene
# Organism	VGLU1_HUMAN	Homo sapiens (Human)
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-210500	Glutamate Neurotransmitter Release Cycle
# Reactome	R-HSA-428643	Organic anion transporters
# RecName	VGLU1_HUMAN	Vesicular glutamate transporter 1
# RefSeq	NP_064705	NM_020309.3. [Q9P2U7-1]
# SIMILARITY	Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	VGLU1_HUMAN	Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO 0000250|UniProtKB Q3TXX4}. Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. Cell junction, synapse, synaptosome {ECO 0000250|UniProtKB Q3TXX4}. 
# SUBUNIT	Interacts with SHANK3. {ECO	0000250}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.14.30	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	Expressed in several regions of the brain including amygdala, cerebellum, cerebral cortex, hippocampus, frontal lobe, medulla, occipital lobe, putamen and temporal lobe. {ECO:0000269|PubMed	10820226}. 
# TopDownProteomics	Q9P2U7-1	-. [Q9P2U7-1]
# UCSC	uc002pnp	human. [Q9P2U7-1]
# eggNOG	ENOG410XPWC	LUCA
# eggNOG	KOG2532	Eukaryota
BLAST	swissprot:VGLU1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VGLU1_HUMAN
BioCyc	ZFISH:ENSG00000104888-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000104888-MONOMER
COXPRESdb	57030	http://coxpresdb.jp/data/gene/57030.shtml
CleanEx	HS_SLC17A7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC17A7
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1046/j.1471-4159.2000.0742622.x	http://dx.doi.org/10.1046/j.1471-4159.2000.0742622.x
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB032436	http://www.ebi.ac.uk/ena/data/view/AB032436
EMBL	AC010619	http://www.ebi.ac.uk/ena/data/view/AC010619
EMBL	AK294226	http://www.ebi.ac.uk/ena/data/view/AK294226
EMBL	AK294405	http://www.ebi.ac.uk/ena/data/view/AK294405
EMBL	BC059379	http://www.ebi.ac.uk/ena/data/view/BC059379
EMBL	CH471177	http://www.ebi.ac.uk/ena/data/view/CH471177
Ensembl	ENST00000221485	http://www.ensembl.org/id/ENST00000221485
Ensembl	ENST00000600601	http://www.ensembl.org/id/ENST00000600601
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030672	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030672
GO_component	GO:0044300	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044300
GO_component	GO:0048786	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048786
GO_component	GO:0060076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060076
GO_component	GO:0060203	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060203
GO_component	GO:0098794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098794
GO_function	GO:0005313	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005313
GO_function	GO:0005315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005315
GO_function	GO:0008068	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008068
GO_function	GO:0015319	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015319
GO_function	GO:0015321	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015321
GO_process	GO:0003407	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003407
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006817	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006817
GO_process	GO:0006836	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006836
GO_process	GO:0007420	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007420
GO_process	GO:0007616	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007616
GO_process	GO:0014047	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014047
GO_process	GO:0035249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035249
GO_process	GO:0042137	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042137
GO_process	GO:0051938	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051938
GO_process	GO:0060079	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060079
GO_process	GO:0097401	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097401
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	SLC17A7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC17A7
GeneID	57030	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57030
GeneTree	ENSGT00760000119079	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119079
HGNC	HGNC:16704	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16704
HOGENOM	HOG000230812	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230812&db=HOGENOM6
HOVERGEN	HBG008834	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG008834&db=HOVERGEN
HPA	CAB037183	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB037183
HPA	HPA050458	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA050458
HPA	HPA063679	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA063679
InParanoid	Q9P2U7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9P2U7
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	57030	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=57030
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:57030	http://www.genome.jp/dbget-bin/www_bget?hsa:57030
KEGG_Orthology	KO:K12302	http://www.genome.jp/dbget-bin/www_bget?KO:K12302
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
MIM	605208	http://www.ncbi.nlm.nih.gov/omim/605208
OMA	DKSEEYV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DKSEEYV
OrthoDB	EOG091G06DG	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G06DG
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:VGLU1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VGLU1_HUMAN
PSORT-B	swissprot:VGLU1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VGLU1_HUMAN
PSORT2	swissprot:VGLU1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VGLU1_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA423	http://www.pharmgkb.org/do/serve?objId=PA423&objCls=Gene
Phobius	swissprot:VGLU1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VGLU1_HUMAN
PhylomeDB	Q9P2U7	http://phylomedb.org/?seqid=Q9P2U7
ProteinModelPortal	Q9P2U7	http://www.proteinmodelportal.org/query/uniprot/Q9P2U7
PubMed	10820226	http://www.ncbi.nlm.nih.gov/pubmed/10820226
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-210500	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-210500
Reactome	R-HSA-428643	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428643
RefSeq	NP_064705	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_064705
STRING	9606.ENSP00000221485	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000221485&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.14.30	http://www.tcdb.org/search/result.php?tc=2.A.1.14.30
UCSC	uc002pnp	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002pnp&org=rat
UniGene	Hs.375616	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.375616
UniProtKB	VGLU1_HUMAN	http://www.uniprot.org/uniprot/VGLU1_HUMAN
UniProtKB-AC	Q9P2U7	http://www.uniprot.org/uniprot/Q9P2U7
charge	swissprot:VGLU1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VGLU1_HUMAN
eggNOG	ENOG410XPWC	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPWC
eggNOG	KOG2532	http://eggnogapi.embl.de/nog_data/html/tree/KOG2532
epestfind	swissprot:VGLU1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VGLU1_HUMAN
garnier	swissprot:VGLU1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VGLU1_HUMAN
helixturnhelix	swissprot:VGLU1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VGLU1_HUMAN
hmoment	swissprot:VGLU1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VGLU1_HUMAN
iep	swissprot:VGLU1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VGLU1_HUMAN
inforesidue	swissprot:VGLU1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VGLU1_HUMAN
neXtProt	NX_Q9P2U7	http://www.nextprot.org/db/entry/NX_Q9P2U7
octanol	swissprot:VGLU1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VGLU1_HUMAN
pepcoil	swissprot:VGLU1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VGLU1_HUMAN
pepdigest	swissprot:VGLU1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VGLU1_HUMAN
pepinfo	swissprot:VGLU1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VGLU1_HUMAN
pepnet	swissprot:VGLU1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VGLU1_HUMAN
pepstats	swissprot:VGLU1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VGLU1_HUMAN
pepwheel	swissprot:VGLU1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VGLU1_HUMAN
pepwindow	swissprot:VGLU1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VGLU1_HUMAN
sigcleave	swissprot:VGLU1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VGLU1_HUMAN
## Database	ID	URL or Descriptions
# AltName	CX6B2_HUMAN	Cancer/testis antigen 59
# AltName	CX6B2_HUMAN	Cytochrome c oxidase subunit VIb isoform 2
# AltName	CX6B2_HUMAN	Cytochrome c oxidase subunit VIb, testis-specific isoform
# BioGrid	125940	2
# CDD	cd00926	Cyt_c_Oxidase_VIb
# Ensembl	ENST00000326529	ENSP00000320672; ENSG00000160471
# Ensembl	ENST00000588572	ENSP00000467959; ENSG00000160471
# Ensembl	ENST00000589467	ENSP00000476768; ENSG00000160471
# Ensembl	ENST00000590900	ENSP00000467128; ENSG00000160471
# Ensembl	ENST00000593184	ENSP00000467266; ENSG00000160471
# FUNCTION	CX6B2_HUMAN	Connects the two COX monomers into the physiological dimeric form. {ECO 0000250}. 
# GO_component	GO:0005758	mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
# GO_component	GO:0030061	mitochondrial crista; IDA:MGI.
# GO_function	GO:0004129	cytochrome-c oxidase activity; IEA:InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# Gene3D	1.10.10.140	-; 1.
# Genevisible	Q6YFQ2	HS
# HGNC	HGNC:24380	COX6B2
# INTERACTION	CX6B2_HUMAN	Q96NE9 FRMD6; NbExp=3; IntAct=EBI-10291911, EBI-741729; 
# IntAct	Q6YFQ2	2
# InterPro	IPR003213	Cyt_c_oxidase_su6B
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# Organism	CX6B2_HUMAN	Homo sapiens (Human)
# PIRSF	PIRSF000278	Cyt_c_oxidase_6B
# PROSITE	PS51808	CHCH
# Pfam	PF02297	COX6B
# Proteomes	UP000005640	Chromosome 19
# RecName	CX6B2_HUMAN	Cytochrome c oxidase subunit 6B2
# RefSeq	NP_653214	NM_144613.4
# SIMILARITY	Belongs to the cytochrome c oxidase subunit 6B family. {ECO	0000305}. 
# SIMILARITY	Contains 1 CHCH (coiled coil-helix-coiled coil-helix) domain. {ECO:0000255|PROSITE-ProRule	PRU01150}.
# SUBCELLULAR LOCATION	CX6B2_HUMAN	Mitochondrion intermembrane space {ECO 0000250}. 
# SUPFAM	SSF47694	SSF47694
# TCDB	3.D.4.11	the proton-translocating cytochrome oxidase (cox) superfamily
# TISSUE SPECIFICITY	CX6B2_HUMAN	Testis specific. Weak expression in thymus and heart. Expressed in cancer cell lines. {ECO 0000269|PubMed 12874793, ECO 0000269|PubMed 15905330}. 
# UCSC	uc002qkn	human
# eggNOG	ENOG41121WM	LUCA
# eggNOG	KOG3057	Eukaryota
BLAST	swissprot:CX6B2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CX6B2_HUMAN
BioCyc	ZFISH:HS14814-MONOMER	http://biocyc.org/getid?id=ZFISH:HS14814-MONOMER
COXPRESdb	125965	http://coxpresdb.jp/data/gene/125965.shtml
CleanEx	HS_COX6B2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_COX6B2
DOI	10.1002/mrd.10327	http://dx.doi.org/10.1002/mrd.10327
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0502583102	http://dx.doi.org/10.1073/pnas.0502583102
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AK057427	http://www.ebi.ac.uk/ena/data/view/AK057427
EMBL	AY152398	http://www.ebi.ac.uk/ena/data/view/AY152398
EMBL	BC026123	http://www.ebi.ac.uk/ena/data/view/BC026123
EMBL	BC100899	http://www.ebi.ac.uk/ena/data/view/BC100899
EMBL	BC100900	http://www.ebi.ac.uk/ena/data/view/BC100900
EMBL	BC100901	http://www.ebi.ac.uk/ena/data/view/BC100901
EMBL	BC100902	http://www.ebi.ac.uk/ena/data/view/BC100902
Ensembl	ENST00000326529	http://www.ensembl.org/id/ENST00000326529
Ensembl	ENST00000588572	http://www.ensembl.org/id/ENST00000588572
Ensembl	ENST00000589467	http://www.ensembl.org/id/ENST00000589467
Ensembl	ENST00000590900	http://www.ensembl.org/id/ENST00000590900
Ensembl	ENST00000593184	http://www.ensembl.org/id/ENST00000593184
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005758	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005758
GO_component	GO:0030061	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030061
GO_function	GO:0004129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004129
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
Gene3D	1.10.10.140	http://www.cathdb.info/version/latest/superfamily/1.10.10.140
GeneCards	COX6B2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=COX6B2
GeneID	125965	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=125965
GeneTree	ENSGT00390000001191	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000001191
HGNC	HGNC:24380	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:24380
HOGENOM	HOG000165128	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000165128&db=HOGENOM6
HOVERGEN	HBG051090	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051090&db=HOVERGEN
HPA	HPA035014	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035014
InParanoid	Q6YFQ2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6YFQ2
IntAct	Q6YFQ2	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q6YFQ2*
InterPro	IPR003213	http://www.ebi.ac.uk/interpro/entry/IPR003213
Jabion	125965	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=125965
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Gene	hsa:125965	http://www.genome.jp/dbget-bin/www_bget?hsa:125965
KEGG_Orthology	KO:K02267	http://www.genome.jp/dbget-bin/www_bget?KO:K02267
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
OMA	ISWVQRW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ISWVQRW
OrthoDB	EOG091G0UIB	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0UIB
PROSITE	PS51808	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51808
PSORT	swissprot:CX6B2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CX6B2_HUMAN
PSORT-B	swissprot:CX6B2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CX6B2_HUMAN
PSORT2	swissprot:CX6B2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CX6B2_HUMAN
Pfam	PF02297	http://pfam.xfam.org/family/PF02297
PharmGKB	PA134869389	http://www.pharmgkb.org/do/serve?objId=PA134869389&objCls=Gene
Phobius	swissprot:CX6B2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CX6B2_HUMAN
PhylomeDB	Q6YFQ2	http://phylomedb.org/?seqid=Q6YFQ2
ProteinModelPortal	Q6YFQ2	http://www.proteinmodelportal.org/query/uniprot/Q6YFQ2
PubMed	12874793	http://www.ncbi.nlm.nih.gov/pubmed/12874793
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15905330	http://www.ncbi.nlm.nih.gov/pubmed/15905330
RefSeq	NP_653214	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_653214
SMR	Q6YFQ2	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q6YFQ2
STRING	9606.ENSP00000320672	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000320672&targetmode=cogs
SUPFAM	SSF47694	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47694
TCDB	3.D.4.11	http://www.tcdb.org/search/result.php?tc=3.D.4.11
UCSC	uc002qkn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002qkn&org=rat
UniGene	Hs.550544	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.550544
UniProtKB	CX6B2_HUMAN	http://www.uniprot.org/uniprot/CX6B2_HUMAN
UniProtKB-AC	Q6YFQ2	http://www.uniprot.org/uniprot/Q6YFQ2
charge	swissprot:CX6B2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CX6B2_HUMAN
eggNOG	ENOG41121WM	http://eggnogapi.embl.de/nog_data/html/tree/ENOG41121WM
eggNOG	KOG3057	http://eggnogapi.embl.de/nog_data/html/tree/KOG3057
epestfind	swissprot:CX6B2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CX6B2_HUMAN
garnier	swissprot:CX6B2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CX6B2_HUMAN
helixturnhelix	swissprot:CX6B2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CX6B2_HUMAN
hmoment	swissprot:CX6B2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CX6B2_HUMAN
iep	swissprot:CX6B2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CX6B2_HUMAN
inforesidue	swissprot:CX6B2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CX6B2_HUMAN
neXtProt	NX_Q6YFQ2	http://www.nextprot.org/db/entry/NX_Q6YFQ2
octanol	swissprot:CX6B2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CX6B2_HUMAN
pepcoil	swissprot:CX6B2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CX6B2_HUMAN
pepdigest	swissprot:CX6B2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CX6B2_HUMAN
pepinfo	swissprot:CX6B2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CX6B2_HUMAN
pepnet	swissprot:CX6B2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CX6B2_HUMAN
pepstats	swissprot:CX6B2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CX6B2_HUMAN
pepwheel	swissprot:CX6B2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CX6B2_HUMAN
pepwindow	swissprot:CX6B2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CX6B2_HUMAN
sigcleave	swissprot:CX6B2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CX6B2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S22AH_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=NgalR-1; IsoId=Q8WUG5-1; Sequence=Displayed; Name=2; Synonyms=NgalR-2; IsoId=Q8WUG5-2; Sequence=VSP_003774; Name=3; Synonyms=NgalR-3; IsoId=Q8WUG5-3; Sequence=VSP_039782, VSP_039783; 
# AltName	S22AH_HUMAN	24p3 receptor
# AltName	S22AH_HUMAN	Brain-type organic cation transporter
# AltName	S22AH_HUMAN	Lipocalin-2 receptor
# AltName	S22AH_HUMAN	Neutrophil gelatinase-associated lipocalin receptor
# CCDS	CCDS9593	-. [Q8WUG5-1]
# CCDS	CCDS9594	-. [Q8WUG5-2]
# CDD	cd06174	MFS
# ChiTaRS	SLC22A17	human
# Ensembl	ENST00000206544	ENSP00000206544; ENSG00000092096. [Q8WUG5-1]
# Ensembl	ENST00000397267	ENSP00000380437; ENSG00000092096. [Q8WUG5-1]
# ExpressionAtlas	Q8WUG5	baseline and differential
# FUNCTION	S22AH_HUMAN	Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity). {ECO 0000250}. 
# GO_component	GO:0005774	vacuolar membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0031301	integral component of organelle membrane; IDA:UniProtKB.
# GO_function	GO:0004888	transmembrane signaling receptor activity; ISS:UniProtKB.
# GO_function	GO:0008514	organic anion transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0022857	transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0006879	cellular iron ion homeostasis; TAS:Reactome.
# GO_process	GO:0015891	siderophore transport; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0042592	homeostatic process
# Genevisible	Q8WUG5	HS
# HGNC	HGNC:23095	SLC22A17
# INDUCTION	S22AH_HUMAN	Expression is activated by RUNX3. Repressed by the oncoprotein BCR-ABL; BCR-ABL misregulates expression by inducing a switch in binding from RUNX3 to RUNX1, a repressor of 24p3R expression, through a Ras signaling pathway. {ECO 0000269|PubMed 16377569, ECO 0000269|PubMed 19229297}. 
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR005829	Sugar_transporter_CS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	611461	gene
# Organism	S22AH_HUMAN	Homo sapiens (Human)
# PROSITE	PS00216	SUGAR_TRANSPORT_1; 2
# PROSITE	PS50850	MFS
# Pfam	PF00083	Sugar_tr
# Proteomes	UP000005640	Chromosome 14
# Reactome	R-HSA-917937	Iron uptake and transport
# RecName	S22AH_HUMAN	Solute carrier family 22 member 17
# RefSeq	NP_001275979	NM_001289050.1
# RefSeq	NP_057693	NM_016609.4. [Q8WUG5-2]
# RefSeq	NP_065105	NM_020372.3. [Q8WUG5-1]
# RefSeq	XP_005267804	XM_005267747.4. [Q8WUG5-1]
# RefSeq	XP_016876850	XM_017021361.1. [Q8WUG5-1]
# RefSeq	XP_016876851	XM_017021362.1. [Q8WUG5-2]
# SEQUENCE CAUTION	Sequence=CAC01119.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC17762.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S22AH_HUMAN	Cell membrane {ECO 0000269|PubMed 17253959}; Multi-pass membrane protein {ECO 0000269|PubMed 17253959}. Vacuole membrane {ECO 0000269|PubMed 17253959}; Multi-pass membrane protein {ECO 0000269|PubMed 17253959}. Note=Upon LCN2-binding, it is internalized. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.19	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	S22AH_HUMAN	Expressed in brain. 
# UCSC	uc001wjl	human. [Q8WUG5-1]
# eggNOG	ENOG410IRI7	Eukaryota
# eggNOG	ENOG411129W	LUCA
BLAST	swissprot:S22AH_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S22AH_HUMAN
BioCyc	ZFISH:ENSG00000092096-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000092096-MONOMER
COXPRESdb	51310	http://coxpresdb.jp/data/gene/51310.shtml
CleanEx	HS_SLC22A17	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC22A17
DOI	10.1016/j.cell.2005.10.027	http://dx.doi.org/10.1016/j.cell.2005.10.027
DOI	10.1038/emboj.2009.35	http://dx.doi.org/10.1038/emboj.2009.35
DOI	10.1038/nature01348	http://dx.doi.org/10.1038/nature01348
DOI	10.1042/BJ20060836	http://dx.doi.org/10.1042/BJ20060836
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AJ243122	http://www.ebi.ac.uk/ena/data/view/AJ243122
EMBL	AJ243653	http://www.ebi.ac.uk/ena/data/view/AJ243653
EMBL	AL049829	http://www.ebi.ac.uk/ena/data/view/AL049829
EMBL	BC020565	http://www.ebi.ac.uk/ena/data/view/BC020565
EMBL	BC090870	http://www.ebi.ac.uk/ena/data/view/BC090870
EMBL	BC111015	http://www.ebi.ac.uk/ena/data/view/BC111015
EMBL	BX161416	http://www.ebi.ac.uk/ena/data/view/BX161416
EMBL	DQ658848	http://www.ebi.ac.uk/ena/data/view/DQ658848
Ensembl	ENST00000206544	http://www.ensembl.org/id/ENST00000206544
Ensembl	ENST00000397267	http://www.ensembl.org/id/ENST00000397267
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005774	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005774
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0031301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031301
GO_function	GO:0004888	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004888
GO_function	GO:0008514	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008514
GO_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GO_process	GO:0006879	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006879
GO_process	GO:0015891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015891
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GeneCards	SLC22A17	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC22A17
GeneID	51310	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51310
GeneTree	ENSGT00390000014377	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000014377
HGNC	HGNC:23095	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:23095
HOVERGEN	HBG031124	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG031124&db=HOVERGEN
HPA	HPA002728	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA002728
InParanoid	Q8WUG5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8WUG5
IntAct	Q8WUG5	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8WUG5*
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR005829	http://www.ebi.ac.uk/interpro/entry/IPR005829
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	51310	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=51310
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:51310	http://www.genome.jp/dbget-bin/www_bget?hsa:51310
KEGG_Orthology	KO:K08213	http://www.genome.jp/dbget-bin/www_bget?KO:K08213
MIM	611461	http://www.ncbi.nlm.nih.gov/omim/611461
OMA	TRLELCE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TRLELCE
OrthoDB	EOG091G07Y4	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07Y4
PROSITE	PS00216	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00216
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:S22AH_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S22AH_HUMAN
PSORT-B	swissprot:S22AH_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S22AH_HUMAN
PSORT2	swissprot:S22AH_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S22AH_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
PharmGKB	PA134879149	http://www.pharmgkb.org/do/serve?objId=PA134879149&objCls=Gene
Phobius	swissprot:S22AH_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S22AH_HUMAN
PhylomeDB	Q8WUG5	http://phylomedb.org/?seqid=Q8WUG5
ProteinModelPortal	Q8WUG5	http://www.proteinmodelportal.org/query/uniprot/Q8WUG5
PubMed	12508121	http://www.ncbi.nlm.nih.gov/pubmed/12508121
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16377569	http://www.ncbi.nlm.nih.gov/pubmed/16377569
PubMed	17253959	http://www.ncbi.nlm.nih.gov/pubmed/17253959
PubMed	19229297	http://www.ncbi.nlm.nih.gov/pubmed/19229297
Reactome	R-HSA-917937	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917937
RefSeq	NP_001275979	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001275979
RefSeq	NP_057693	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_057693
RefSeq	NP_065105	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_065105
RefSeq	XP_005267804	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005267804
RefSeq	XP_016876850	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016876850
RefSeq	XP_016876851	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016876851
STRING	9606.ENSP00000206544	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000206544&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.19	http://www.tcdb.org/search/result.php?tc=2.A.1.19
UCSC	uc001wjl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001wjl&org=rat
UniGene	Hs.373498	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.373498
UniProtKB	S22AH_HUMAN	http://www.uniprot.org/uniprot/S22AH_HUMAN
UniProtKB-AC	Q8WUG5	http://www.uniprot.org/uniprot/Q8WUG5
charge	swissprot:S22AH_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S22AH_HUMAN
eggNOG	ENOG410IRI7	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IRI7
eggNOG	ENOG411129W	http://eggnogapi.embl.de/nog_data/html/tree/ENOG411129W
epestfind	swissprot:S22AH_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S22AH_HUMAN
garnier	swissprot:S22AH_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S22AH_HUMAN
helixturnhelix	swissprot:S22AH_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S22AH_HUMAN
hmoment	swissprot:S22AH_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S22AH_HUMAN
iep	swissprot:S22AH_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S22AH_HUMAN
inforesidue	swissprot:S22AH_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S22AH_HUMAN
neXtProt	NX_Q8WUG5	http://www.nextprot.org/db/entry/NX_Q8WUG5
octanol	swissprot:S22AH_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S22AH_HUMAN
pepcoil	swissprot:S22AH_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S22AH_HUMAN
pepdigest	swissprot:S22AH_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S22AH_HUMAN
pepinfo	swissprot:S22AH_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S22AH_HUMAN
pepnet	swissprot:S22AH_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S22AH_HUMAN
pepstats	swissprot:S22AH_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S22AH_HUMAN
pepwheel	swissprot:S22AH_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S22AH_HUMAN
pepwindow	swissprot:S22AH_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S22AH_HUMAN
sigcleave	swissprot:S22AH_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S22AH_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CACB1_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Beta-1b2, BetaA, Beta-1B, Beta1-2; IsoId=Q02641-1; Sequence=Displayed; Name=2; Synonyms=Beta-1M, BetaC, Beta-1a; IsoId=Q02641-2; Sequence=VSP_000623, VSP_000624, VSP_000625; Name=3; Synonyms=Beta-1b1, BetaB, Beta-1c, Beta1-3; IsoId=Q02641-3; Sequence=VSP_000624, VSP_000625; 
# AltName	CACB1_HUMAN	Calcium channel voltage-dependent subunit beta 1
# BioGrid	107236	9
# CCDS	CCDS11334	-. [Q02641-2]
# CCDS	CCDS42311	-. [Q02641-1]
# CCDS	CCDS45665	-. [Q02641-3]
# DrugBank	DB00308	Ibutilide
# DrugBank	DB00393	Nimodipine
# DrugBank	DB00421	Spironolactone
# DrugBank	DB00653	Magnesium Sulfate
# DrugBank	DB00661	Verapamil
# DrugBank	DB00898	Ethanol
# DrugBank	DB04855	Dronedarone
# Ensembl	ENST00000344140	ENSP00000345461; ENSG00000067191. [Q02641-2]
# Ensembl	ENST00000394303	ENSP00000377840; ENSG00000067191. [Q02641-1]
# Ensembl	ENST00000394310	ENSP00000377847; ENSG00000067191. [Q02641-3]
# ExpressionAtlas	Q02641	baseline and differential
# FUNCTION	CACB1_HUMAN	The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005891	voltage-gated calcium channel complex; TAS:ProtInc.
# GO_component	GO:0042383	sarcolemma; IEA:UniProtKB-SubCell.
# GO_function	GO:0005245	voltage-gated calcium channel activity; TAS:ProtInc.
# GO_function	GO:0008331	high voltage-gated calcium channel activity; IBA:GO_Central.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007268	chemical synaptic transmission; IBA:GO_Central.
# GO_process	GO:0007528	neuromuscular junction development; IBA:GO_Central.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:1901385	regulation of voltage-gated calcium channel activity; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# Gene3D	3.40.50.300	-; 1.
# Genevisible	Q02641	HS
# HGNC	HGNC:1401	CACNB1
# IntAct	Q02641	2
# InterPro	IPR000584	VDCC_L_bsu
# InterPro	IPR001452	SH3_domain
# InterPro	IPR005443	VDCC_L_b1su
# InterPro	IPR008145	GK/Ca_channel_bsu
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04010	MAPK signaling pathway
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05410	Hypertrophic cardiomyopathy (HCM)
# KEGG_Pathway	ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
# KEGG_Pathway	ko05414	Dilated cardiomyopathy
# MIM	114207	gene
# Organism	CACB1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11824	PTHR11824
# PIR	A44461	A44461
# PIR	B44461	B44461
# PIR	C44461	C44461
# PIR	I38002	I38002
# PIR	I52859	I52859
# PIR	I65766	I65766
# PIR	I65767	I65767
# PIR	JH0566	JH0566
# PRINTS	PR01626	LCACHANNELB
# PRINTS	PR01627	LCACHANNELB1
# PROSITE	PS50002	SH3
# Pfam	PF00625	Guanylate_kin
# Pfam	PF12052	VGCC_beta4Aa_N
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-112308	Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
# Reactome	R-HSA-419037	NCAM1 interactions
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# Reactome	R-HSA-5576893	Phase 2 - plateau phase
# Reactome	R-HSA-5576894	Phase 1 - inactivation of fast Na+ channels
# RecName	CACB1_HUMAN	Voltage-dependent L-type calcium channel subunit beta-1
# RefSeq	NP_000714	NM_000723.4. [Q02641-1]
# RefSeq	NP_954855	NM_199247.2. [Q02641-2]
# RefSeq	NP_954856	NM_199248.2. [Q02641-3]
# SEQUENCE CAUTION	Sequence=CAA79825.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the calcium channel beta subunit family. {ECO	0000305}. 
# SIMILARITY	Contains 1 SH3 domain. {ECO:0000255|PROSITE- ProRule	PRU00192}. 
# SMART	SM00072	GuKc
# SUBCELLULAR LOCATION	CACB1_HUMAN	Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. 
# SUBUNIT	The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with JSRP1. Interacts with RYR1. Interacts with CBARP (By similarity). {ECO	0000250}. 
# SUPFAM	SSF50044	SSF50044
# SUPFAM	SSF52540	SSF52540
# TISSUE SPECIFICITY	Isoform 1 and isoform 3 are expressed in brain, heart, spleen, central nervous system and neuroblastoma cells. Isoform 2 is expressed in skeletal muscle. {ECO:0000269|PubMed	8107964}. 
# UCSC	uc002hrm	human. [Q02641-1]
# eggNOG	ENOG410XRDI	LUCA
# eggNOG	KOG3812	Eukaryota
BLAST	swissprot:CACB1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CACB1_HUMAN
BioCyc	ZFISH:ENSG00000067191-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000067191-MONOMER
COXPRESdb	782	http://coxpresdb.jp/data/gene/782.shtml
CleanEx	HS_CACNB1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CACNB1
DOI	10.1016/0028-3908(93)90004-M	http://dx.doi.org/10.1016/0028-3908(93)90004-M
DOI	10.1016/0304-3940(96)13055-X	http://dx.doi.org/10.1016/0304-3940(96)13055-X
DOI	10.1016/0896-6273(92)90109-Q	http://dx.doi.org/10.1016/0896-6273(92)90109-Q
DOI	10.1016/S0304-3940(99)00851-4	http://dx.doi.org/10.1016/S0304-3940(99)00851-4
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/hmg/2.7.863	http://dx.doi.org/10.1093/hmg/2.7.863
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1161/01.RES.72.6.1337	http://dx.doi.org/10.1161/01.RES.72.6.1337
DrugBank	DB00308	http://www.drugbank.ca/drugs/DB00308
DrugBank	DB00393	http://www.drugbank.ca/drugs/DB00393
DrugBank	DB00421	http://www.drugbank.ca/drugs/DB00421
DrugBank	DB00653	http://www.drugbank.ca/drugs/DB00653
DrugBank	DB00661	http://www.drugbank.ca/drugs/DB00661
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB04855	http://www.drugbank.ca/drugs/DB04855
EMBL	AB054985	http://www.ebi.ac.uk/ena/data/view/AB054985
EMBL	AK289729	http://www.ebi.ac.uk/ena/data/view/AK289729
EMBL	BC037311	http://www.ebi.ac.uk/ena/data/view/BC037311
EMBL	CH471152	http://www.ebi.ac.uk/ena/data/view/CH471152
EMBL	L06110	http://www.ebi.ac.uk/ena/data/view/L06110
EMBL	L06111	http://www.ebi.ac.uk/ena/data/view/L06111
EMBL	L06112	http://www.ebi.ac.uk/ena/data/view/L06112
EMBL	M76560	http://www.ebi.ac.uk/ena/data/view/M76560
EMBL	M92301	http://www.ebi.ac.uk/ena/data/view/M92301
EMBL	M92302	http://www.ebi.ac.uk/ena/data/view/M92302
EMBL	M92303	http://www.ebi.ac.uk/ena/data/view/M92303
EMBL	U86952	http://www.ebi.ac.uk/ena/data/view/U86952
EMBL	U86952	http://www.ebi.ac.uk/ena/data/view/U86952
EMBL	U86952	http://www.ebi.ac.uk/ena/data/view/U86952
EMBL	U86953	http://www.ebi.ac.uk/ena/data/view/U86953
EMBL	U86953	http://www.ebi.ac.uk/ena/data/view/U86953
EMBL	U86953	http://www.ebi.ac.uk/ena/data/view/U86953
EMBL	U86954	http://www.ebi.ac.uk/ena/data/view/U86954
EMBL	U86954	http://www.ebi.ac.uk/ena/data/view/U86954
EMBL	U86954	http://www.ebi.ac.uk/ena/data/view/U86954
EMBL	U86955	http://www.ebi.ac.uk/ena/data/view/U86955
EMBL	U86955	http://www.ebi.ac.uk/ena/data/view/U86955
EMBL	U86955	http://www.ebi.ac.uk/ena/data/view/U86955
EMBL	U86956	http://www.ebi.ac.uk/ena/data/view/U86956
EMBL	U86956	http://www.ebi.ac.uk/ena/data/view/U86956
EMBL	U86956	http://www.ebi.ac.uk/ena/data/view/U86956
EMBL	U86957	http://www.ebi.ac.uk/ena/data/view/U86957
EMBL	U86957	http://www.ebi.ac.uk/ena/data/view/U86957
EMBL	U86957	http://www.ebi.ac.uk/ena/data/view/U86957
EMBL	U86958	http://www.ebi.ac.uk/ena/data/view/U86958
EMBL	U86958	http://www.ebi.ac.uk/ena/data/view/U86958
EMBL	U86958	http://www.ebi.ac.uk/ena/data/view/U86958
EMBL	U86959	http://www.ebi.ac.uk/ena/data/view/U86959
EMBL	U86959	http://www.ebi.ac.uk/ena/data/view/U86959
EMBL	U86959	http://www.ebi.ac.uk/ena/data/view/U86959
EMBL	U86960	http://www.ebi.ac.uk/ena/data/view/U86960
EMBL	U86960	http://www.ebi.ac.uk/ena/data/view/U86960
EMBL	U86960	http://www.ebi.ac.uk/ena/data/view/U86960
EMBL	U86961	http://www.ebi.ac.uk/ena/data/view/U86961
EMBL	Z21725	http://www.ebi.ac.uk/ena/data/view/Z21725
EMBL	Z21726	http://www.ebi.ac.uk/ena/data/view/Z21726
Ensembl	ENST00000344140	http://www.ensembl.org/id/ENST00000344140
Ensembl	ENST00000394303	http://www.ensembl.org/id/ENST00000394303
Ensembl	ENST00000394310	http://www.ensembl.org/id/ENST00000394310
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005891
GO_component	GO:0042383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042383
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0008331	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008331
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007528	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007528
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:1901385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901385
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	CACNB1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CACNB1
GeneID	782	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=782
GeneTree	ENSGT00390000002740	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002740
HGNC	HGNC:1401	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1401
HOVERGEN	HBG050765	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050765&db=HOVERGEN
HPA	CAB009779	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB009779
HPA	HPA023343	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA023343
InParanoid	Q02641	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q02641
IntAct	Q02641	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q02641*
InterPro	IPR000584	http://www.ebi.ac.uk/interpro/entry/IPR000584
InterPro	IPR001452	http://www.ebi.ac.uk/interpro/entry/IPR001452
InterPro	IPR005443	http://www.ebi.ac.uk/interpro/entry/IPR005443
InterPro	IPR008145	http://www.ebi.ac.uk/interpro/entry/IPR008145
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	782	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=782
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:782	http://www.genome.jp/dbget-bin/www_bget?hsa:782
KEGG_Orthology	KO:K04862	http://www.genome.jp/dbget-bin/www_bget?KO:K04862
KEGG_Pathway	ko04010	http://www.genome.jp/kegg-bin/show_pathway?ko04010
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05410	http://www.genome.jp/kegg-bin/show_pathway?ko05410
KEGG_Pathway	ko05412	http://www.genome.jp/kegg-bin/show_pathway?ko05412
KEGG_Pathway	ko05414	http://www.genome.jp/kegg-bin/show_pathway?ko05414
MIM	114207	http://www.ncbi.nlm.nih.gov/omim/114207
MINT	MINT-2857287	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-2857287
OMA	SFWGGLE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SFWGGLE
OrthoDB	EOG091G09C1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G09C1
PANTHER	PTHR11824	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11824
PRINTS	PR01626	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01626
PRINTS	PR01627	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01627
PROSITE	PS50002	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50002
PSORT	swissprot:CACB1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CACB1_HUMAN
PSORT-B	swissprot:CACB1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CACB1_HUMAN
PSORT2	swissprot:CACB1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CACB1_HUMAN
Pfam	PF00625	http://pfam.xfam.org/family/PF00625
Pfam	PF12052	http://pfam.xfam.org/family/PF12052
PharmGKB	PA87	http://www.pharmgkb.org/do/serve?objId=PA87&objCls=Gene
Phobius	swissprot:CACB1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CACB1_HUMAN
PhylomeDB	Q02641	http://phylomedb.org/?seqid=Q02641
ProteinModelPortal	Q02641	http://www.proteinmodelportal.org/query/uniprot/Q02641
PubMed	10624822	http://www.ncbi.nlm.nih.gov/pubmed/10624822
PubMed	1309651	http://www.ncbi.nlm.nih.gov/pubmed/1309651
PubMed	1385409	http://www.ncbi.nlm.nih.gov/pubmed/1385409
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	7916667	http://www.ncbi.nlm.nih.gov/pubmed/7916667
PubMed	8107964	http://www.ncbi.nlm.nih.gov/pubmed/8107964
PubMed	8395940	http://www.ncbi.nlm.nih.gov/pubmed/8395940
PubMed	8905728	http://www.ncbi.nlm.nih.gov/pubmed/8905728
Reactome	R-HSA-112308	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112308
Reactome	R-HSA-419037	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-419037
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
Reactome	R-HSA-5576893	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576893
Reactome	R-HSA-5576894	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576894
RefSeq	NP_000714	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000714
RefSeq	NP_954855	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_954855
RefSeq	NP_954856	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_954856
SMART	SM00072	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00072
SMR	Q02641	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q02641
STRING	9606.ENSP00000377840	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000377840&targetmode=cogs
SUPFAM	SSF50044	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50044
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
UCSC	uc002hrm	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002hrm&org=rat
UniGene	Hs.635	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.635
UniProtKB	CACB1_HUMAN	http://www.uniprot.org/uniprot/CACB1_HUMAN
UniProtKB-AC	Q02641	http://www.uniprot.org/uniprot/Q02641
charge	swissprot:CACB1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CACB1_HUMAN
eggNOG	ENOG410XRDI	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRDI
eggNOG	KOG3812	http://eggnogapi.embl.de/nog_data/html/tree/KOG3812
epestfind	swissprot:CACB1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CACB1_HUMAN
garnier	swissprot:CACB1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CACB1_HUMAN
helixturnhelix	swissprot:CACB1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CACB1_HUMAN
hmoment	swissprot:CACB1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CACB1_HUMAN
iep	swissprot:CACB1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CACB1_HUMAN
inforesidue	swissprot:CACB1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CACB1_HUMAN
neXtProt	NX_Q02641	http://www.nextprot.org/db/entry/NX_Q02641
octanol	swissprot:CACB1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CACB1_HUMAN
pepcoil	swissprot:CACB1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CACB1_HUMAN
pepdigest	swissprot:CACB1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CACB1_HUMAN
pepinfo	swissprot:CACB1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CACB1_HUMAN
pepnet	swissprot:CACB1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CACB1_HUMAN
pepstats	swissprot:CACB1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CACB1_HUMAN
pepwheel	swissprot:CACB1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CACB1_HUMAN
pepwindow	swissprot:CACB1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CACB1_HUMAN
sigcleave	swissprot:CACB1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CACB1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AT1B4_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=A; IsoId=Q9UN42-1; Sequence=Displayed; Name=B; IsoId=Q9UN42-2; Sequence=VSP_000351; 
# AltName	AT1B4_HUMAN	X,K-ATPase subunit beta-m
# AltName	AT1B4_HUMAN	X/potassium-transporting ATPase subunit beta-m
# BioGrid	117007	38
# CCDS	CCDS14598	-. [Q9UN42-2]
# CCDS	CCDS48158	-. [Q9UN42-1]
# Ensembl	ENST00000218008	ENSP00000218008; ENSG00000101892. [Q9UN42-1]
# Ensembl	ENST00000361319	ENSP00000355346; ENSG00000101892. [Q9UN42-2]
# ExpressionAtlas	Q9UN42	baseline and differential
# FUNCTION	AT1B4_HUMAN	May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit. {ECO 0000269|PubMed 17592128}. 
# GO_component	AT1B4_HUMAN	GO 0005890 sodium potassium-exchanging ATPase complex; IEA InterPro.
# GO_component	GO:0005635	nuclear envelope; TAS:Reactome.
# GO_component	GO:0005637	nuclear inner membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_function	GO:0015077	monovalent inorganic cation transmembrane transporter activity; TAS:ProtInc.
# GO_process	GO:0006351	transcription, DNA-templated; IEA:UniProtKB-KW.
# GO_process	GO:0006355	regulation of transcription, DNA-templated; IDA:UniProtKB.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005635	nuclear envelope
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# Genevisible	Q9UN42	HS
# HGNC	HGNC:808	ATP1B4
# InterPro	IPR000402	Na/K_ATPase_sub_beta
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04090	 Cellular antigens
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko04960	Aldosterone-regulated sodium reabsorption
# KEGG_Pathway	ko04961	Endocrine and other factor-regulated calcium reabsorption
# KEGG_Pathway	ko04964	Proximal tubule bicarbonate reclamation
# KEGG_Pathway	ko04970	Salivary secretion
# KEGG_Pathway	ko04971	Gastric acid secretion
# KEGG_Pathway	ko04972	Pancreatic secretion
# KEGG_Pathway	ko04973	Carbohydrate digestion and absorption
# KEGG_Pathway	ko04974	Protein digestion and absorption
# KEGG_Pathway	ko04976	Bile secretion
# KEGG_Pathway	ko04978	Mineral absorption
# Organism	AT1B4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11523	PTHR11523
# PROSITE	PS00390	ATPASE_NA_K_BETA_1
# PROSITE	PS00391	ATPASE_NA_K_BETA_2
# Pfam	PF00287	Na_K-ATPase
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-2173796:SMAD2/SMAD3	SMAD4 heterotrimer regulates transcription
# RecName	AT1B4_HUMAN	Protein ATP1B4
# RefSeq	NP_001135919	NM_001142447.2. [Q9UN42-1]
# RefSeq	NP_036201	NM_012069.4. [Q9UN42-2]
# SIMILARITY	Belongs to the X(+)/potassium ATPases subunit beta family. {ECO	0000305}.
# SUBCELLULAR LOCATION	AT1B4_HUMAN	Nucleus inner membrane {ECO 0000250}; Single-pass type II membrane protein {ECO 0000250}. Note=Detected in nuclear envelops. {ECO 0000269|PubMed 14656723, ECO 0000269|PubMed 17592128}. 
# SUBUNIT	Associates with a SMAD7-transcriptional complex. Interacts with SNW1 and TOR1AIP1 (By similarity). According to PubMed:17592128, does not associate with known Na,K-ATPase alpha- subunits. {ECO	0000250}. 
# TIGRFAMs	TIGR01107	Na_K_ATPase_bet
# TISSUE SPECIFICITY	Highly expressed in skeletal muscle and at a lower level in heart. {ECO:0000269|PubMed	10456317}. 
# UCSC	uc004esq	human. [Q9UN42-1]
# eggNOG	ENOG411150A	LUCA
# eggNOG	KOG3927	Eukaryota
BLAST	swissprot:AT1B4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AT1B4_HUMAN
BioCyc	ZFISH:ENSG00000101892-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000101892-MONOMER
COXPRESdb	23439	http://coxpresdb.jp/data/gene/23439.shtml
CleanEx	HS_ATP1B4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP1B4
DIP	DIP-60961N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-60961N
DOI	10.1016/S0014-5793(99)00954-0	http://dx.doi.org/10.1016/S0014-5793(99)00954-0
DOI	10.1073/pnas.0704809104	http://dx.doi.org/10.1073/pnas.0704809104
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1152/ajpcell.00358.2003	http://dx.doi.org/10.1152/ajpcell.00358.2003
EMBL	AF158383	http://www.ebi.ac.uk/ena/data/view/AF158383
EMBL	AF158384	http://www.ebi.ac.uk/ena/data/view/AF158384
EMBL	BC117227	http://www.ebi.ac.uk/ena/data/view/BC117227
Ensembl	ENST00000218008	http://www.ensembl.org/id/ENST00000218008
Ensembl	ENST00000361319	http://www.ensembl.org/id/ENST00000361319
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GO_component	GO:0005637	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005637
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005890
GO_function	GO:0015077	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015077
GO_process	GO:0006351	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351
GO_process	GO:0006355	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0045944	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045944
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GeneCards	ATP1B4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP1B4
GeneID	23439	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23439
GeneTree	ENSGT00550000074530	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074530
HGNC	HGNC:808	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:808
HOGENOM	HOG000039248	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000039248&db=HOGENOM6
HOVERGEN	HBG050603	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050603&db=HOVERGEN
InParanoid	Q9UN42	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UN42
InterPro	IPR000402	http://www.ebi.ac.uk/interpro/entry/IPR000402
Jabion	23439	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=23439
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04090	http://www.genome.jp/dbget-bin/www_bget?ko04090
KEGG_Gene	hsa:23439	http://www.genome.jp/dbget-bin/www_bget?hsa:23439
KEGG_Orthology	KO:K01540	http://www.genome.jp/dbget-bin/www_bget?KO:K01540
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko04960	http://www.genome.jp/kegg-bin/show_pathway?ko04960
KEGG_Pathway	ko04961	http://www.genome.jp/kegg-bin/show_pathway?ko04961
KEGG_Pathway	ko04964	http://www.genome.jp/kegg-bin/show_pathway?ko04964
KEGG_Pathway	ko04970	http://www.genome.jp/kegg-bin/show_pathway?ko04970
KEGG_Pathway	ko04971	http://www.genome.jp/kegg-bin/show_pathway?ko04971
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
KEGG_Pathway	ko04973	http://www.genome.jp/kegg-bin/show_pathway?ko04973
KEGG_Pathway	ko04974	http://www.genome.jp/kegg-bin/show_pathway?ko04974
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
KEGG_Pathway	ko04978	http://www.genome.jp/kegg-bin/show_pathway?ko04978
OMA	PTGNAWW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PTGNAWW
OrthoDB	EOG091G0DJ4	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0DJ4
PANTHER	PTHR11523	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11523
PROSITE	PS00390	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00390
PROSITE	PS00391	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00391
PSORT	swissprot:AT1B4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AT1B4_HUMAN
PSORT-B	swissprot:AT1B4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AT1B4_HUMAN
PSORT2	swissprot:AT1B4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AT1B4_HUMAN
Pfam	PF00287	http://pfam.xfam.org/family/PF00287
PharmGKB	PA410	http://www.pharmgkb.org/do/serve?objId=PA410&objCls=Gene
Phobius	swissprot:AT1B4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AT1B4_HUMAN
PhylomeDB	Q9UN42	http://phylomedb.org/?seqid=Q9UN42
ProteinModelPortal	Q9UN42	http://www.proteinmodelportal.org/query/uniprot/Q9UN42
PubMed	10456317	http://www.ncbi.nlm.nih.gov/pubmed/10456317
PubMed	14656723	http://www.ncbi.nlm.nih.gov/pubmed/14656723
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17592128	http://www.ncbi.nlm.nih.gov/pubmed/17592128
Reactome	R-HSA-2173796	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2173796
RefSeq	NP_001135919	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001135919
RefSeq	NP_036201	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_036201
STRING	9606.ENSP00000218008	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000218008&targetmode=cogs
TIGRFAMs	TIGR01107	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01107
UCSC	uc004esq	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004esq&org=rat
UniGene	Hs.292599	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.292599
UniProtKB	AT1B4_HUMAN	http://www.uniprot.org/uniprot/AT1B4_HUMAN
UniProtKB-AC	Q9UN42	http://www.uniprot.org/uniprot/Q9UN42
charge	swissprot:AT1B4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AT1B4_HUMAN
eggNOG	ENOG411150A	http://eggnogapi.embl.de/nog_data/html/tree/ENOG411150A
eggNOG	KOG3927	http://eggnogapi.embl.de/nog_data/html/tree/KOG3927
epestfind	swissprot:AT1B4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AT1B4_HUMAN
garnier	swissprot:AT1B4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AT1B4_HUMAN
helixturnhelix	swissprot:AT1B4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AT1B4_HUMAN
hmoment	swissprot:AT1B4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AT1B4_HUMAN
iep	swissprot:AT1B4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AT1B4_HUMAN
inforesidue	swissprot:AT1B4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AT1B4_HUMAN
neXtProt	NX_Q9UN42	http://www.nextprot.org/db/entry/NX_Q9UN42
octanol	swissprot:AT1B4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AT1B4_HUMAN
pepcoil	swissprot:AT1B4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AT1B4_HUMAN
pepdigest	swissprot:AT1B4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AT1B4_HUMAN
pepinfo	swissprot:AT1B4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AT1B4_HUMAN
pepnet	swissprot:AT1B4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AT1B4_HUMAN
pepstats	swissprot:AT1B4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AT1B4_HUMAN
pepwheel	swissprot:AT1B4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AT1B4_HUMAN
pepwindow	swissprot:AT1B4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AT1B4_HUMAN
sigcleave	swissprot:AT1B4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AT1B4_HUMAN
## Database	ID	URL or Descriptions
# AltName	EAA3_HUMAN	Excitatory amino-acid carrier 1
# AltName	EAA3_HUMAN	Neuronal and epithelial glutamate transporter
# AltName	EAA3_HUMAN	Sodium-dependent glutamate/aspartate transporter 3
# AltName	EAA3_HUMAN	Solute carrier family 1 member 1
# BioGrid	112396	33
# ChiTaRS	SLC1A1	human
# DISEASE	EAA3_HUMAN	Dicarboxylic aminoaciduria (DCBXA) [MIM 222730]  An autosomal recessive disorder characterized by abnormal excretion of urinary glutamate and aspartate, resulting from the incomplete reabsorption of anionic amino acids from the glomerular filtrate in the kidney. It can be associated with mental retardation. {ECO 0000269|PubMed 21123949}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	EAA3_HUMAN	Schizophrenia 18 (SCZD18) [MIM 615232]  A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. {ECO 0000269|PubMed 21982423, ECO 0000269|PubMed 23341099}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. A deletion at the chromosome 9p24.2 locus, including SLC1A1, has been identified in patients with psychotic disorders (PubMed 21982423). This 84 kb deletion is immediately upstream of the SLC1A1 gene in a regulatory region that contains the full native promoter sequence, extends through exon 1 of the SLC1A1 mRNA, co-segregates with disease in an extended 5-generation pedigree and increases disease risk more than 18-fold for family members (PubMed 23341099). {ECO 0000269|PubMed 21982423, ECO 0000269|PubMed 23341099}. 
# DrugBank	DB00128	L-Aspartic Acid
# DrugBank	DB00230	Pregabalin
# Ensembl	ENST00000262352	ENSP00000262352; ENSG00000106688
# ExpressionAtlas	P43005	baseline and differential
# FUNCTION	EAA3_HUMAN	Transports L-glutamate, L- and D-aspartate and L-cystein (PubMed 21123949). Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity). {ECO 0000250|UniProtKB P51906, ECO 0000250|UniProtKB P51907, ECO 0000269|PubMed 21123949}. 
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	EAA3_HUMAN	GO 0015501 glutamate sodium symporter activity; IEA Ensembl.
# GO_function	GO:0005313	L-glutamate transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0005314	high-affinity glutamate transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0016595	glutamate binding; IEA:Ensembl.
# GO_function	GO:0033229	cysteine transmembrane transporter activity; IDA:UniProtKB.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:ProtInc.
# GO_process	GO:0010460	positive regulation of heart rate; IEA:Ensembl.
# GO_process	GO:0014047	glutamate secretion; TAS:Reactome.
# GO_process	GO:0042883	cysteine transport; IDA:UniProtKB.
# GO_process	GO:0051260	protein homooligomerization; IEA:Ensembl.
# GO_process	GO:0051938	L-glutamate import; IDA:UniProtKB.
# GO_process	GO:0070779	D-aspartate import; IDA:UniProtKB.
# GO_process	GO:0089711	L-glutamate transmembrane transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.10.3860.10	-; 2.
# Genevisible	P43005	HS
# HGNC	HGNC:10939	SLC1A1
# INTERACTION	EAA3_HUMAN	Q5T700 LDLRAD1; NbExp=3; IntAct=EBI-745376, EBI-10173166; Q99942 RNF5; NbExp=3; IntAct=EBI-745376, EBI-348482; 
# IntAct	P43005	3
# InterPro	IPR001991	Na-dicarboxylate_symporter
# InterPro	IPR018107	Na-dicarboxylate_symporter_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H00911	[Urinary system disease; Kidney disease; Inherited metabolic disease] Dicarboxylic aminoaciduria
# KEGG_Disease	H01450	[Mental and behavioural disorders] Obsessive-compulsive disorder (OCD)
# KEGG_Pathway	ko04724	Glutamatergic synapse
# KEGG_Pathway	ko04974	Protein digestion and absorption
# MIM	133550	gene
# MIM	222730	phenotype
# MIM	615232	phenotype
# Organism	EAA3_HUMAN	Homo sapiens (Human)
# Orphanet	2195	Dicarboxylic aminoaciduria
# Orphanet	3140	Schizophrenia
# PANTHER	PTHR11958	PTHR11958
# PIR	A54856	A54856
# PIR	I38433	I38433
# PIR	I38560	I38560
# PRINTS	PR00173	EDTRNSPORT
# PROSITE	PS00713	NA_DICARBOXYL_SYMP_1
# PROSITE	PS00714	NA_DICARBOXYL_SYMP_2
# PTM	EAA3_HUMAN	Glycosylated. 
# Pfam	PF00375	SDF
# Proteomes	UP000005640	Chromosome 9
# Reactome	R-HSA-210500	Glutamate Neurotransmitter Release Cycle
# Reactome	R-HSA-425393	Transport of inorganic cations/anions and amino acids/oligopeptides
# RecName	EAA3_HUMAN	Excitatory amino acid transporter 3
# RefSeq	NP_004161	NM_004170.5
# SIMILARITY	Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A1 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	EAA3_HUMAN	Cell membrane {ECO 0000269|PubMed 21123949}; Multi-pass membrane protein. Apical cell membrane {ECO 0000269|PubMed 21123949}; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. 
# SUBUNIT	Interacts with ARL6IP5. {ECO:0000250|UniProtKB	P51906}. 
# SUPFAM	SSF118215	SSF118215; 2
# TCDB	2.A.23.2:the dicarboxylate/amino acid	cation (na(+) or h(+)) symporter (daacs) family
# TISSUE SPECIFICITY	EAA3_HUMAN	Expressed in all tissues tested including liver, muscle, testis, ovary, retinoblastoma cell line, neurons and brain (in which there was dense expression in substantia nigra, red nucleus, hippocampus and in cerebral cortical layers). {ECO 0000269|PubMed 7521911, ECO 0000269|PubMed 7859077, ECO 0000269|PubMed 7914198}. 
# UCSC	uc003zij	human
# eggNOG	COG1301	LUCA
# eggNOG	KOG3787	Eukaryota
BLAST	swissprot:EAA3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:EAA3_HUMAN
BioCyc	ZFISH:ENSG00000106688-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000106688-MONOMER
COXPRESdb	6505	http://coxpresdb.jp/data/gene/6505.shtml
CleanEx	HS_SLC1A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC1A1
DOI	10.1002/ajmg.b.32125	http://dx.doi.org/10.1002/ajmg.b.32125
DOI	10.1016/0006-8993(94)90819-2	http://dx.doi.org/10.1016/0006-8993(94)90819-2
DOI	10.1016/j.biopsych.2011.08.009	http://dx.doi.org/10.1016/j.biopsych.2011.08.009
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
DOI	10.1038/sj.mp.4000806	http://dx.doi.org/10.1038/sj.mp.4000806
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1172/JCI44474	http://dx.doi.org/10.1172/JCI44474
DrugBank	DB00128	http://www.drugbank.ca/drugs/DB00128
DrugBank	DB00230	http://www.drugbank.ca/drugs/DB00230
EMBL	AB008536	http://www.ebi.ac.uk/ena/data/view/AB008536
EMBL	AF037982	http://www.ebi.ac.uk/ena/data/view/AF037982
EMBL	AF074903	http://www.ebi.ac.uk/ena/data/view/AF074903
EMBL	AF074904	http://www.ebi.ac.uk/ena/data/view/AF074904
EMBL	AF074905	http://www.ebi.ac.uk/ena/data/view/AF074905
EMBL	AF074906	http://www.ebi.ac.uk/ena/data/view/AF074906
EMBL	AF074907	http://www.ebi.ac.uk/ena/data/view/AF074907
EMBL	AF074908	http://www.ebi.ac.uk/ena/data/view/AF074908
EMBL	AF074909	http://www.ebi.ac.uk/ena/data/view/AF074909
EMBL	AF074910	http://www.ebi.ac.uk/ena/data/view/AF074910
EMBL	AF074911	http://www.ebi.ac.uk/ena/data/view/AF074911
EMBL	AF143773	http://www.ebi.ac.uk/ena/data/view/AF143773
EMBL	AL136231	http://www.ebi.ac.uk/ena/data/view/AL136231
EMBL	AL136231	http://www.ebi.ac.uk/ena/data/view/AL136231
EMBL	AL162587	http://www.ebi.ac.uk/ena/data/view/AL162587
EMBL	AL162587	http://www.ebi.ac.uk/ena/data/view/AL162587
EMBL	BC033040	http://www.ebi.ac.uk/ena/data/view/BC033040
EMBL	U03506	http://www.ebi.ac.uk/ena/data/view/U03506
EMBL	U06469	http://www.ebi.ac.uk/ena/data/view/U06469
EMBL	U08989	http://www.ebi.ac.uk/ena/data/view/U08989
Ensembl	ENST00000262352	http://www.ensembl.org/id/ENST00000262352
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005313	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005313
GO_function	GO:0005314	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005314
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_function	GO:0015501	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015501
GO_function	GO:0016595	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016595
GO_function	GO:0033229	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033229
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0010460	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010460
GO_process	GO:0014047	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014047
GO_process	GO:0042883	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042883
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:0051938	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051938
GO_process	GO:0070779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070779
GO_process	GO:0089711	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0089711
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.10.3860.10	http://www.cathdb.info/version/latest/superfamily/1.10.3860.10
GeneCards	SLC1A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC1A1
GeneID	6505	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6505
GeneTree	ENSGT00760000119117	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119117
HGNC	HGNC:10939	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10939
HOGENOM	HOG000208776	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000208776&db=HOGENOM6
HOVERGEN	HBG000080	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000080&db=HOVERGEN
HPA	CAB015466	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB015466
HPA	HPA020086	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA020086
InParanoid	P43005	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P43005
IntAct	P43005	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P43005*
InterPro	IPR001991	http://www.ebi.ac.uk/interpro/entry/IPR001991
InterPro	IPR018107	http://www.ebi.ac.uk/interpro/entry/IPR018107
Jabion	6505	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6505
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00911	http://www.genome.jp/dbget-bin/www_bget?H00911
KEGG_Disease	H01450	http://www.genome.jp/dbget-bin/www_bget?H01450
KEGG_Gene	hsa:6505	http://www.genome.jp/dbget-bin/www_bget?hsa:6505
KEGG_Orthology	KO:K05612	http://www.genome.jp/dbget-bin/www_bget?KO:K05612
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
KEGG_Pathway	ko04974	http://www.genome.jp/kegg-bin/show_pathway?ko04974
MIM	133550	http://www.ncbi.nlm.nih.gov/omim/133550
MIM	222730	http://www.ncbi.nlm.nih.gov/omim/222730
MIM	615232	http://www.ncbi.nlm.nih.gov/omim/615232
OMA	CEKKSYV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CEKKSYV
Orphanet	2195	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=2195
Orphanet	3140	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=3140
OrthoDB	EOG091G0UCE	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0UCE
PANTHER	PTHR11958	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11958
PRINTS	PR00173	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00173
PROSITE	PS00713	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00713
PROSITE	PS00714	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00714
PSORT	swissprot:EAA3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:EAA3_HUMAN
PSORT-B	swissprot:EAA3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:EAA3_HUMAN
PSORT2	swissprot:EAA3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:EAA3_HUMAN
Pfam	PF00375	http://pfam.xfam.org/family/PF00375
PharmGKB	PA35826	http://www.pharmgkb.org/do/serve?objId=PA35826&objCls=Gene
Phobius	swissprot:EAA3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:EAA3_HUMAN
PhylomeDB	P43005	http://phylomedb.org/?seqid=P43005
ProteinModelPortal	P43005	http://www.proteinmodelportal.org/query/uniprot/P43005
PubMed	11317217	http://www.ncbi.nlm.nih.gov/pubmed/11317217
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21123949	http://www.ncbi.nlm.nih.gov/pubmed/21123949
PubMed	21982423	http://www.ncbi.nlm.nih.gov/pubmed/21982423
PubMed	23341099	http://www.ncbi.nlm.nih.gov/pubmed/23341099
PubMed	7521911	http://www.ncbi.nlm.nih.gov/pubmed/7521911
PubMed	7859077	http://www.ncbi.nlm.nih.gov/pubmed/7859077
PubMed	7914198	http://www.ncbi.nlm.nih.gov/pubmed/7914198
Reactome	R-HSA-210500	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-210500
Reactome	R-HSA-425393	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425393
RefSeq	NP_004161	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004161
STRING	9606.ENSP00000262352	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000262352&targetmode=cogs
SUPFAM	SSF118215	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF118215
TCDB	2.A.23.2	http://www.tcdb.org/search/result.php?tc=2.A.23.2
UCSC	uc003zij	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003zij&org=rat
UniGene	Hs.444915	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.444915
UniProtKB	EAA3_HUMAN	http://www.uniprot.org/uniprot/EAA3_HUMAN
UniProtKB-AC	P43005	http://www.uniprot.org/uniprot/P43005
charge	swissprot:EAA3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:EAA3_HUMAN
eggNOG	COG1301	http://eggnogapi.embl.de/nog_data/html/tree/COG1301
eggNOG	KOG3787	http://eggnogapi.embl.de/nog_data/html/tree/KOG3787
epestfind	swissprot:EAA3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:EAA3_HUMAN
garnier	swissprot:EAA3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:EAA3_HUMAN
helixturnhelix	swissprot:EAA3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:EAA3_HUMAN
hmoment	swissprot:EAA3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:EAA3_HUMAN
iep	swissprot:EAA3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:EAA3_HUMAN
inforesidue	swissprot:EAA3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:EAA3_HUMAN
neXtProt	NX_P43005	http://www.nextprot.org/db/entry/NX_P43005
octanol	swissprot:EAA3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:EAA3_HUMAN
pepcoil	swissprot:EAA3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:EAA3_HUMAN
pepdigest	swissprot:EAA3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:EAA3_HUMAN
pepinfo	swissprot:EAA3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:EAA3_HUMAN
pepnet	swissprot:EAA3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:EAA3_HUMAN
pepstats	swissprot:EAA3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:EAA3_HUMAN
pepwheel	swissprot:EAA3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:EAA3_HUMAN
pepwindow	swissprot:EAA3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:EAA3_HUMAN
sigcleave	swissprot:EAA3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:EAA3_HUMAN
## Database	ID	URL or Descriptions
# AltName	SC5A7_HUMAN	Hemicholinium-3-sensitive choline transporter
# AltName	SC5A7_HUMAN	Solute carrier family 5 member 7
# BioGrid	121915	2
# DISEASE	SC5A7_HUMAN	Neuronopathy, distal hereditary motor, 7A (HMN7A) [MIM 158580]  A neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs. HMN7A is characterized by onset in the second decade of progressive distal muscle wasting and weakness affecting the upper and lower limbs and resulting in walking difficulties and hand grip. There is significant muscle atrophy of the hands and lower limbs. The disorder is associated with vocal cord paresis due to involvement of the tenth cranial nerve. {ECO 0000269|PubMed 23141292}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00122	Choline
# Ensembl	ENST00000264047	ENSP00000264047; ENSG00000115665
# Ensembl	ENST00000409059	ENSP00000387346; ENSG00000115665
# FUNCTION	SC5A7_HUMAN	Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion- dependent. {ECO 0000269|PubMed 11027560}. 
# GO_component	GO:0005886	plasma membrane; IDA:MGI.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IDA:UniProtKB.
# GO_component	GO:0030424	axon; IBA:GO_Central.
# GO_component	GO:0030425	dendrite; IBA:GO_Central.
# GO_component	GO:0043204	perikaryon; IBA:GO_Central.
# GO_component	GO:0045202	synapse; IBA:GO_Central.
# GO_component	GO:0098793	presynapse; IEA:GOC.
# GO_function	GO:0015220	choline transmembrane transporter activity; IMP:UniProtKB.
# GO_function	GO:0033265	choline binding; IBA:GO_Central.
# GO_function	SC5A7_HUMAN	GO 0005307 choline sodium symporter activity; IMP MGI.
# GO_process	GO:0007269	neurotransmitter secretion; TAS:Reactome.
# GO_process	GO:0007271	synaptic transmission, cholinergic; IBA:GO_Central.
# GO_process	GO:0007274	neuromuscular synaptic transmission; IBA:GO_Central.
# GO_process	GO:0008292	acetylcholine biosynthetic process; IMP:UniProtKB.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9GZV3	HS
# HGNC	HGNC:14025	SLC5A7
# InterPro	IPR001734	Na/solute_symporter
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04725	Cholinergic synapse
# MIM	158580	phenotype
# MIM	608761	gene
# MISCELLANEOUS	SC5A7_HUMAN	Specifically inhibited by nanomolar concentrations of hemicholinium 3. 
# Organism	SC5A7_HUMAN	Homo sapiens (Human)
# Orphanet	139589	Distal hereditary motor neuropathy type 7
# PANTHER	PTHR11819	PTHR11819
# PIR	JC7502	JC7502
# PROSITE	PS50283	NA_SOLUT_SYMP_3
# PTM	SC5A7_HUMAN	Phosphorylated. {ECO 0000250}. 
# Pfam	PF00474	SSF
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-264642	Acetylcholine Neurotransmitter Release Cycle
# Reactome	R-HSA-425366	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
# RecName	SC5A7_HUMAN	High affinity choline transporter 1
# RefSeq	NP_001291934	NM_001305005.2
# RefSeq	NP_068587	NM_021815.4
# SIMILARITY	Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	SC5A7_HUMAN	Membrane {ECO 0000269|PubMed 11027560}; Multi-pass membrane protein {ECO 0000269|PubMed 11027560}. 
# SUBUNIT	SC5A7_HUMAN	Homooligomerizes at cell surface (PubMed 23132865). Interacts with SEC14L1; may regulate SLC5A7 (PubMed 17092608). {ECO 0000269|PubMed 17092608, ECO 0000269|PubMed 23132865}. 
# TCDB	2.A.21.8:the solute	sodium symporter (sss) family
# TISSUE SPECIFICITY	SC5A7_HUMAN	Expressed in putamen, spinal cord and medulla. Specific for cholinergic neurons. 
# UCSC	uc002tdv	human
# eggNOG	COG0591	LUCA
# eggNOG	KOG3761	Eukaryota
BLAST	swissprot:SC5A7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SC5A7_HUMAN
BioCyc	ZFISH:ENSG00000115665-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000115665-MONOMER
COXPRESdb	60482	http://coxpresdb.jp/data/gene/60482.shtml
CleanEx	HS_SLC5A7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC5A7
DOI	10.1006/bbrc.2000.3561	http://dx.doi.org/10.1006/bbrc.2000.3561
DOI	10.1016/S0014-5793(00)02134-7	http://dx.doi.org/10.1016/S0014-5793(00)02134-7
DOI	10.1016/j.ajhg.2012.09.019	http://dx.doi.org/10.1016/j.ajhg.2012.09.019
DOI	10.1016/j.neuint.2006.09.010	http://dx.doi.org/10.1016/j.neuint.2006.09.010
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1074/jbc.M112.405027	http://dx.doi.org/10.1074/jbc.M112.405027
DOI	10.1074/jbc.M207742200	http://dx.doi.org/10.1074/jbc.M207742200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00122	http://www.drugbank.ca/drugs/DB00122
EMBL	AB043997	http://www.ebi.ac.uk/ena/data/view/AB043997
EMBL	AC009963	http://www.ebi.ac.uk/ena/data/view/AC009963
EMBL	AF276871	http://www.ebi.ac.uk/ena/data/view/AF276871
EMBL	AJ308378	http://www.ebi.ac.uk/ena/data/view/AJ308378
EMBL	AJ308379	http://www.ebi.ac.uk/ena/data/view/AJ308379
EMBL	AJ308380	http://www.ebi.ac.uk/ena/data/view/AJ308380
EMBL	AJ308381	http://www.ebi.ac.uk/ena/data/view/AJ308381
EMBL	AJ308382	http://www.ebi.ac.uk/ena/data/view/AJ308382
EMBL	AJ308383	http://www.ebi.ac.uk/ena/data/view/AJ308383
EMBL	AJ308384	http://www.ebi.ac.uk/ena/data/view/AJ308384
EMBL	AJ401466	http://www.ebi.ac.uk/ena/data/view/AJ401466
EMBL	BC111525	http://www.ebi.ac.uk/ena/data/view/BC111525
Ensembl	ENST00000264047	http://www.ensembl.org/id/ENST00000264047
Ensembl	ENST00000409059	http://www.ensembl.org/id/ENST00000409059
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030424	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030424
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0043204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043204
GO_component	GO:0045202	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045202
GO_component	GO:0098793	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098793
GO_function	GO:0005307	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005307
GO_function	GO:0015220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015220
GO_function	GO:0033265	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033265
GO_process	GO:0007269	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007269
GO_process	GO:0007271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007271
GO_process	GO:0007274	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007274
GO_process	GO:0008292	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008292
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC5A7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC5A7
GeneID	60482	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=60482
GeneTree	ENSGT00690000101915	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00690000101915
HGNC	HGNC:14025	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14025
HOGENOM	HOG000016386	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000016386&db=HOGENOM6
HOVERGEN	HBG054160	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054160&db=HOVERGEN
HPA	HPA046105	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA046105
InParanoid	Q9GZV3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9GZV3
InterPro	IPR001734	http://www.ebi.ac.uk/interpro/entry/IPR001734
Jabion	60482	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=60482
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:60482	http://www.genome.jp/dbget-bin/www_bget?hsa:60482
KEGG_Orthology	KO:K14387	http://www.genome.jp/dbget-bin/www_bget?KO:K14387
KEGG_Pathway	ko04725	http://www.genome.jp/kegg-bin/show_pathway?ko04725
MIM	158580	http://www.ncbi.nlm.nih.gov/omim/158580
MIM	608761	http://www.ncbi.nlm.nih.gov/omim/608761
OMA	HAKYQKP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HAKYQKP
Orphanet	139589	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=139589
OrthoDB	EOG091G050W	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G050W
PANTHER	PTHR11819	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11819
PROSITE	PS50283	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50283
PSORT	swissprot:SC5A7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SC5A7_HUMAN
PSORT-B	swissprot:SC5A7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SC5A7_HUMAN
PSORT2	swissprot:SC5A7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SC5A7_HUMAN
Pfam	PF00474	http://pfam.xfam.org/family/PF00474
PharmGKB	PA37838	http://www.pharmgkb.org/do/serve?objId=PA37838&objCls=Gene
Phobius	swissprot:SC5A7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SC5A7_HUMAN
PhylomeDB	Q9GZV3	http://phylomedb.org/?seqid=Q9GZV3
ProteinModelPortal	Q9GZV3	http://www.proteinmodelportal.org/query/uniprot/Q9GZV3
PubMed	11027560	http://www.ncbi.nlm.nih.gov/pubmed/11027560
PubMed	11068039	http://www.ncbi.nlm.nih.gov/pubmed/11068039
PubMed	12237312	http://www.ncbi.nlm.nih.gov/pubmed/12237312
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	17092608	http://www.ncbi.nlm.nih.gov/pubmed/17092608
PubMed	23132865	http://www.ncbi.nlm.nih.gov/pubmed/23132865
PubMed	23141292	http://www.ncbi.nlm.nih.gov/pubmed/23141292
Reactome	R-HSA-264642	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-264642
Reactome	R-HSA-425366	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425366
RefSeq	NP_001291934	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001291934
RefSeq	NP_068587	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_068587
STRING	9606.ENSP00000264047	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000264047&targetmode=cogs
TCDB	2.A.21.8	http://www.tcdb.org/search/result.php?tc=2.A.21.8
UCSC	uc002tdv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002tdv&org=rat
UniGene	Hs.287758	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.287758
UniProtKB	SC5A7_HUMAN	http://www.uniprot.org/uniprot/SC5A7_HUMAN
UniProtKB-AC	Q9GZV3	http://www.uniprot.org/uniprot/Q9GZV3
charge	swissprot:SC5A7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SC5A7_HUMAN
eggNOG	COG0591	http://eggnogapi.embl.de/nog_data/html/tree/COG0591
eggNOG	KOG3761	http://eggnogapi.embl.de/nog_data/html/tree/KOG3761
epestfind	swissprot:SC5A7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SC5A7_HUMAN
garnier	swissprot:SC5A7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SC5A7_HUMAN
helixturnhelix	swissprot:SC5A7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SC5A7_HUMAN
hmoment	swissprot:SC5A7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SC5A7_HUMAN
iep	swissprot:SC5A7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SC5A7_HUMAN
inforesidue	swissprot:SC5A7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SC5A7_HUMAN
neXtProt	NX_Q9GZV3	http://www.nextprot.org/db/entry/NX_Q9GZV3
octanol	swissprot:SC5A7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SC5A7_HUMAN
pepcoil	swissprot:SC5A7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SC5A7_HUMAN
pepdigest	swissprot:SC5A7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SC5A7_HUMAN
pepinfo	swissprot:SC5A7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SC5A7_HUMAN
pepnet	swissprot:SC5A7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SC5A7_HUMAN
pepstats	swissprot:SC5A7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SC5A7_HUMAN
pepwheel	swissprot:SC5A7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SC5A7_HUMAN
pepwindow	swissprot:SC5A7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SC5A7_HUMAN
sigcleave	swissprot:SC5A7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SC5A7_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	NALCN_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8IZF0-1; Sequence=Displayed; Name=2; IsoId=Q8IZF0-2; Sequence=VSP_030190, VSP_030191; Name=3; IsoId=Q8IZF0-3; Sequence=VSP_030188, VSP_030189; 
# AltName	NALCN_HUMAN	CanIon
# AltName	NALCN_HUMAN	Voltage gated channel-like protein 1
# BioGrid	129228	3
# CCDS	CCDS9498	-. [Q8IZF0-1]
# ChiTaRS	NALCN	human
# DISEASE	NALCN_HUMAN	Congenital contractures of the limbs and face, hypotonia, and developmental delay (CLIFAHDD) [MIM 616266]  A disease characterized by congenital contractures of the limbs and face, resulting in characteristic facial features, abnormal tone, most commonly manifested as hypotonia, and variable degrees of developmental delay. {ECO 0000269|PubMed 25683120}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	NALCN_HUMAN	Hypotonia, infantile, with psychomotor retardation and characteristic facies 1 (IHPRF1) [MIM 615419]  A neurodegenerative disease characterized by variable degrees of hypotonia, speech impairment, intellectual disability, pyramidal signs, subtle facial dysmorphism, and chronic constipation. Some patients manifest neuroaxonal dystrophy, optic atrophy, unmyelinated axons and spheroid bodies in tissue biopsies. {ECO 0000269|PubMed 23749988, ECO 0000269|PubMed 24075186}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	NALCN_HUMAN	Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor. S4 transmembrane segments lack some of the charged residues (K and R) found at every third position in the S4s of the NaV, CaV, and KV channels. Pore-forming loops (P loops) between S5 and S6 of each domain form an EEKE sodium- ion selectivity filter a mixture between the EEEE found in the CaVs and the DEKA of NaVs. {ECO 0000250|UniProtKB Q8BXR5}. 
# Ensembl	ENST00000251127	ENSP00000251127; ENSG00000102452. [Q8IZF0-1]
# Ensembl	ENST00000376200	ENSP00000365373; ENSG00000102452. [Q8IZF0-3]
# ExpressionAtlas	Q8IZF0	baseline and differential
# FUNCTION	NALCN_HUMAN	Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Regulates the resting membrane potential and controls neuronal excitability (PubMed 17448995). Neuropeptides such as neurotensin and substance P (SP) stimulate the firing of action potentials by activating NALCN through a SRC family kinases-dependent pathway. In addition to its baseline activity, NALCN activity is enhanced/modulated by several GPCRs. Required for normal respiratory rhythm and neonatal survival. Involved in systemic osmoregulation by controlling the serum sodium concentration. NALCN is partly responsible for the substance P-induced depolarization and regulation of the intestinal pace-making activity in the interstitial cells of Cajal. Plays a critical role in both maintenance of spontaneous firing of substantia nigra pars reticulata (SNr) neurons and physiological modulation of SNr neuron excitability (By similarity). {ECO 0000250|UniProtKB Q8BXR5, ECO 0000269|PubMed 17448995}. 
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005244	voltage-gated ion channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0005261	cation channel activity; ISS:UniProtKB.
# GO_function	GO:0005272	sodium channel activity; TAS:Reactome.
# GO_function	GO:0022840	leak channel activity; ISS:UniProtKB.
# GO_process	GO:0006816	calcium ion transport; IBA:GO_Central.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0035725	sodium ion transmembrane transport; ISS:UniProtKB.
# GO_process	GO:0060075	regulation of resting membrane potential; ISS:UniProtKB.
# GO_process	GO:0070588	calcium ion transmembrane transport; ISS:UniProtKB.
# GO_process	GO:0071805	potassium ion transmembrane transport; ISS:UniProtKB.
# GO_process	GO:0086010	membrane depolarization during action potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.350	-; 4.
# Genevisible	Q8IZF0	HS
# HGNC	HGNC:19082	NALCN
# INTERACTION	NALCN_HUMAN	P20309 CHRM3; NbExp=3; IntAct=EBI-7085333, EBI-2687785; A4D127 MEOX2; NbExp=3; IntAct=EBI-7085333, EBI-10172134; 
# IntAct	Q8IZF0	2
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028823	NALCN
# MIM	611549	gene
# MIM	615419	phenotype
# MIM	616266	phenotype
# Organism	NALCN_HUMAN	Homo sapiens (Human)
# Orphanet	371364	Hypotonia-speech impairment-severe cognitive delay syndrome
# PANTHER	PTHR10037:SF214	PTHR10037:SF214; 2
# PTM	NALCN_HUMAN	Phosphorylated on tyrosine residues. {ECO 0000250|UniProtKB Q8BXR5}. 
# Pfam	PF00520	Ion_trans; 4
# Proteomes	UP000005640	Chromosome 13
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	NALCN_HUMAN	Sodium leak channel non-selective protein
# RefSeq	NP_443099	NM_052867.2. [Q8IZF0-1]
# RefSeq	XP_011519370	XM_011521068.2. [Q8IZF0-1]
# SEQUENCE CAUTION	Sequence=BAD18738.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the cation-nonselective channel family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	NALCN_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUBUNIT	Interacts with UNC80; required for the NALCN activation/inhibition by GPCRs in neurons. Found in a complex with NALCN, UNC79 and UNC80; UNC80 bridges NALCN to UNC79. Interacts with CHRM3. {ECO:0000250|UniProtKB	Q8BXR5}. 
# TCDB	1.A.1.11.15	the voltage-gated ion channel (vic) superfamily
# UCSC	uc001vox	human. [Q8IZF0-1]
# eggNOG	ENOG410XNP6	LUCA
# eggNOG	KOG2301	Eukaryota
BLAST	swissprot:NALCN_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NALCN_HUMAN
COXPRESdb	259232	http://coxpresdb.jp/data/gene/259232.shtml
CleanEx	HS_NALCN	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_NALCN
DOI	10.1002/humu.22797	http://dx.doi.org/10.1002/humu.22797
DOI	10.1016/j.ajhg.2013.08.001	http://dx.doi.org/10.1016/j.ajhg.2013.08.001
DOI	10.1016/j.ajhg.2015.01.003	http://dx.doi.org/10.1016/j.ajhg.2015.01.003
DOI	10.1016/j.cell.2007.02.041	http://dx.doi.org/10.1016/j.cell.2007.02.041
DOI	10.1038/jhg.2015.163	http://dx.doi.org/10.1038/jhg.2015.163
DOI	10.1038/nature02379	http://dx.doi.org/10.1038/nature02379
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1055/s-0036-1584084	http://dx.doi.org/10.1055/s-0036-1584084
DOI	10.1073/pnas.182412499	http://dx.doi.org/10.1073/pnas.182412499
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1136/jmedgenet-2013-101634	http://dx.doi.org/10.1136/jmedgenet-2013-101634
EMBL	AE014293	http://www.ebi.ac.uk/ena/data/view/AE014293
EMBL	AK172752	http://www.ebi.ac.uk/ena/data/view/AK172752
EMBL	AL138707	http://www.ebi.ac.uk/ena/data/view/AL138707
EMBL	AL138707	http://www.ebi.ac.uk/ena/data/view/AL138707
EMBL	AL138707	http://www.ebi.ac.uk/ena/data/view/AL138707
EMBL	AL354891	http://www.ebi.ac.uk/ena/data/view/AL354891
EMBL	AL354891	http://www.ebi.ac.uk/ena/data/view/AL354891
EMBL	AL354891	http://www.ebi.ac.uk/ena/data/view/AL354891
EMBL	AL356778	http://www.ebi.ac.uk/ena/data/view/AL356778
EMBL	AL356778	http://www.ebi.ac.uk/ena/data/view/AL356778
EMBL	AL356778	http://www.ebi.ac.uk/ena/data/view/AL356778
EMBL	AY141972	http://www.ebi.ac.uk/ena/data/view/AY141972
EMBL	BC028390	http://www.ebi.ac.uk/ena/data/view/BC028390
EMBL	BC064343	http://www.ebi.ac.uk/ena/data/view/BC064343
EMBL	CH471085	http://www.ebi.ac.uk/ena/data/view/CH471085
Ensembl	ENST00000251127	http://www.ensembl.org/id/ENST00000251127
Ensembl	ENST00000376200	http://www.ensembl.org/id/ENST00000376200
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005244
GO_function	GO:0005261	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005261
GO_function	GO:0005272	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005272
GO_function	GO:0022840	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022840
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0035725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035725
GO_process	GO:0060075	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060075
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GO_process	GO:0086010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086010
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	NALCN	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=NALCN
GeneID	259232	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=259232
GeneTree	ENSGT00830000128247	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00830000128247
H-InvDB	HIX0011433	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0011433
HGNC	HGNC:19082	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:19082
HOGENOM	HOG000012967	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000012967&db=HOGENOM6
HOVERGEN	HBG063081	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG063081&db=HOVERGEN
HPA	HPA031889	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031889
HPA	HPA031890	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031890
HPA	HPA031958	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031958
InParanoid	Q8IZF0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8IZF0
IntAct	Q8IZF0	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8IZF0*
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028823	http://www.ebi.ac.uk/interpro/entry/IPR028823
Jabion	259232	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=259232
KEGG_Gene	hsa:259232	http://www.genome.jp/dbget-bin/www_bget?hsa:259232
MIM	611549	http://www.ncbi.nlm.nih.gov/omim/611549
MIM	615419	http://www.ncbi.nlm.nih.gov/omim/615419
MIM	616266	http://www.ncbi.nlm.nih.gov/omim/616266
OMA	MLGDSAM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MLGDSAM
Orphanet	371364	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=371364
OrthoDB	EOG091G00F9	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00F9
PANTHER	PTHR10037:SF214	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10037:SF214
PSORT	swissprot:NALCN_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NALCN_HUMAN
PSORT-B	swissprot:NALCN_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NALCN_HUMAN
PSORT2	swissprot:NALCN_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NALCN_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
PharmGKB	PA162396840	http://www.pharmgkb.org/do/serve?objId=PA162396840&objCls=Gene
Phobius	swissprot:NALCN_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NALCN_HUMAN
PhylomeDB	Q8IZF0	http://phylomedb.org/?seqid=Q8IZF0
ProteinModelPortal	Q8IZF0	http://www.proteinmodelportal.org/query/uniprot/Q8IZF0
PubMed	12364586	http://www.ncbi.nlm.nih.gov/pubmed/12364586
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15057823	http://www.ncbi.nlm.nih.gov/pubmed/15057823
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17448995	http://www.ncbi.nlm.nih.gov/pubmed/17448995
PubMed	23749988	http://www.ncbi.nlm.nih.gov/pubmed/23749988
PubMed	24075186	http://www.ncbi.nlm.nih.gov/pubmed/24075186
PubMed	25683120	http://www.ncbi.nlm.nih.gov/pubmed/25683120
PubMed	25864427	http://www.ncbi.nlm.nih.gov/pubmed/25864427
PubMed	26763878	http://www.ncbi.nlm.nih.gov/pubmed/26763878
PubMed	27214504	http://www.ncbi.nlm.nih.gov/pubmed/27214504
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_443099	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_443099
RefSeq	XP_011519370	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011519370
STRING	9606.ENSP00000251127	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000251127&targetmode=cogs
TCDB	1.A.1.11.15	http://www.tcdb.org/search/result.php?tc=1.A.1.11.15
UCSC	uc001vox	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001vox&org=rat
UniGene	Hs.525146	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.525146
UniProtKB	NALCN_HUMAN	http://www.uniprot.org/uniprot/NALCN_HUMAN
UniProtKB-AC	Q8IZF0	http://www.uniprot.org/uniprot/Q8IZF0
charge	swissprot:NALCN_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NALCN_HUMAN
eggNOG	ENOG410XNP6	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNP6
eggNOG	KOG2301	http://eggnogapi.embl.de/nog_data/html/tree/KOG2301
epestfind	swissprot:NALCN_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NALCN_HUMAN
garnier	swissprot:NALCN_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NALCN_HUMAN
helixturnhelix	swissprot:NALCN_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NALCN_HUMAN
hmoment	swissprot:NALCN_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NALCN_HUMAN
iep	swissprot:NALCN_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NALCN_HUMAN
inforesidue	swissprot:NALCN_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NALCN_HUMAN
neXtProt	NX_Q8IZF0	http://www.nextprot.org/db/entry/NX_Q8IZF0
octanol	swissprot:NALCN_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NALCN_HUMAN
pepcoil	swissprot:NALCN_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NALCN_HUMAN
pepdigest	swissprot:NALCN_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NALCN_HUMAN
pepinfo	swissprot:NALCN_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NALCN_HUMAN
pepnet	swissprot:NALCN_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NALCN_HUMAN
pepstats	swissprot:NALCN_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NALCN_HUMAN
pepwheel	swissprot:NALCN_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NALCN_HUMAN
pepwindow	swissprot:NALCN_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NALCN_HUMAN
sigcleave	swissprot:NALCN_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NALCN_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=9; Name=1; IsoId=Q96GZ6-1; Sequence=Displayed; Name=2; IsoId=Q96GZ6-2; Sequence=VSP_026938; Name=3; IsoId=Q96GZ6-3; Sequence=VSP_026935; Name=4; IsoId=Q96GZ6-4; Sequence=VSP_026935, VSP_026938; Name=5; IsoId=Q96GZ6-5; Sequence=VSP_026934, VSP_026937; Name=6; IsoId=Q96GZ6-6; Sequence=VSP_026936, VSP_026937; Name=7; IsoId=Q96GZ6-7; Sequence=VSP_035505, VSP_035506, VSP_026937; Note=Ref.1 (BAG52701) sequence is in conflict in position: 432	G->S. {ECO:0000305}; Name=8; IsoId=Q96GZ6-8; Sequence=VSP_043676, VSP_026937; Note=No experimental confirmation available.; Name=9; IsoId=Q96GZ6-9; Sequence=VSP_054059, VSP_054060; Note=No experimental confirmation available.; 
# BioGrid	120285	9
# CCDS	CCDS33842	-. [Q96GZ6-3]
# CCDS	CCDS33843	-. [Q96GZ6-1]
# CCDS	CCDS33844	-. [Q96GZ6-7]
# CCDS	CCDS43144	-. [Q96GZ6-9]
# CCDS	CCDS54635	-. [Q96GZ6-8]
# ChiTaRS	SLC41A3	human
# Ensembl	ENST00000315891	ENSP00000326070; ENSG00000114544. [Q96GZ6-1]
# Ensembl	ENST00000346785	ENSP00000264471; ENSG00000114544. [Q96GZ6-3]
# Ensembl	ENST00000360370	ENSP00000353533; ENSG00000114544. [Q96GZ6-9]
# Ensembl	ENST00000383598	ENSP00000373092; ENSG00000114544. [Q96GZ6-7]
# Ensembl	ENST00000508835	ENSP00000427409; ENSG00000114544. [Q96GZ6-8]
# ExpressionAtlas	Q96GZ6	baseline and differential
# GO_component	GO:0005886	plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0008324	cation transmembrane transporter activity; IEA:InterPro.
# GO_process	GO:0055085	transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.10.357.20	-; 2.
# Genevisible	Q96GZ6	HS
# HGNC	HGNC:31046	SLC41A3
# INTERACTION	S41A3_HUMAN	Q86UT5 PDZD3; NbExp=3; IntAct=EBI-7225508, EBI-8744528; Q04864 REL; NbExp=3; IntAct=EBI-7225508, EBI-307352; 
# IntAct	Q96GZ6	5
# InterPro	IPR006667	SLC41_membr_dom
# KEGG_Brite	ko02001	Solute carrier family
# MIM	610803	gene
# Organism	S41A3_HUMAN	Homo sapiens (Human)
# Pfam	PF01769	MgtE; 2
# Proteomes	UP000005640	Chromosome 3
# RecName	S41A3_HUMAN	Solute carrier family 41 member 3
# RefSeq	NP_001008485	NM_001008485.1
# RefSeq	NP_001008486	NM_001008486.1
# RefSeq	NP_001008487	NM_001008487.1. [Q96GZ6-7]
# RefSeq	NP_001157947	NM_001164475.1. [Q96GZ6-8]
# RefSeq	XP_005247619	XM_005247562.1. [Q96GZ6-1]
# RefSeq	XP_005247620	XM_005247563.2. [Q96GZ6-1]
# RefSeq	XP_006713744	XM_006713681.2. [Q96GZ6-1]
# RefSeq	XP_016862195	XM_017006706.1. [Q96GZ6-9]
# RefSeq	XP_016862196	XM_017006707.1. [Q96GZ6-9]
# SIMILARITY	Belongs to the SLC41A transporter family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S41A3_HUMAN	Cell membrane; Multi-pass membrane protein. 
# TCDB	1.A.26.2	the mg(2+) transporter-e (mgte) family
# TopDownProteomics	Q96GZ6-7	-. [Q96GZ6-7]
# UCSC	uc003eii	human. [Q96GZ6-1]
# eggNOG	ENOG410XSTG	LUCA
# eggNOG	KOG3788	Eukaryota
BLAST	swissprot:S41A3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S41A3_HUMAN
COXPRESdb	54946	http://coxpresdb.jp/data/gene/54946.shtml
CleanEx	HS_SLC41A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC41A3
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC079848	http://www.ebi.ac.uk/ena/data/view/AC079848
EMBL	AC092903	http://www.ebi.ac.uk/ena/data/view/AC092903
EMBL	AC117422	http://www.ebi.ac.uk/ena/data/view/AC117422
EMBL	AK000480	http://www.ebi.ac.uk/ena/data/view/AK000480
EMBL	AK021925	http://www.ebi.ac.uk/ena/data/view/AK021925
EMBL	AK022780	http://www.ebi.ac.uk/ena/data/view/AK022780
EMBL	AK091671	http://www.ebi.ac.uk/ena/data/view/AK091671
EMBL	AK093380	http://www.ebi.ac.uk/ena/data/view/AK093380
EMBL	AK298070	http://www.ebi.ac.uk/ena/data/view/AK298070
EMBL	BC009039	http://www.ebi.ac.uk/ena/data/view/BC009039
EMBL	BC009444	http://www.ebi.ac.uk/ena/data/view/BC009444
EMBL	BC028241	http://www.ebi.ac.uk/ena/data/view/BC028241
Ensembl	ENST00000315891	http://www.ensembl.org/id/ENST00000315891
Ensembl	ENST00000346785	http://www.ensembl.org/id/ENST00000346785
Ensembl	ENST00000360370	http://www.ensembl.org/id/ENST00000360370
Ensembl	ENST00000383598	http://www.ensembl.org/id/ENST00000383598
Ensembl	ENST00000508835	http://www.ensembl.org/id/ENST00000508835
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0008324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008324
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.10.357.20	http://www.cathdb.info/version/latest/superfamily/1.10.357.20
GeneCards	SLC41A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC41A3
GeneID	54946	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54946
GeneTree	ENSGT00390000016816	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000016816
HGNC	HGNC:31046	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:31046
HOGENOM	HOG000007017	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007017&db=HOGENOM6
HOVERGEN	HBG057187	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG057187&db=HOVERGEN
HPA	HPA045847	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA045847
InParanoid	Q96GZ6	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96GZ6
IntAct	Q96GZ6	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96GZ6*
InterPro	IPR006667	http://www.ebi.ac.uk/interpro/entry/IPR006667
Jabion	54946	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=54946
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:54946	http://www.genome.jp/dbget-bin/www_bget?hsa:54946
KEGG_Orthology	KO:K15122	http://www.genome.jp/dbget-bin/www_bget?KO:K15122
MIM	610803	http://www.ncbi.nlm.nih.gov/omim/610803
MINT	MINT-4933371	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4933371
OMA	TQLNLEF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TQLNLEF
OrthoDB	EOG091G08MB	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08MB
PSORT	swissprot:S41A3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S41A3_HUMAN
PSORT-B	swissprot:S41A3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S41A3_HUMAN
PSORT2	swissprot:S41A3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S41A3_HUMAN
Pfam	PF01769	http://pfam.xfam.org/family/PF01769
PharmGKB	PA134878151	http://www.pharmgkb.org/do/serve?objId=PA134878151&objCls=Gene
Phobius	swissprot:S41A3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S41A3_HUMAN
PhylomeDB	Q96GZ6	http://phylomedb.org/?seqid=Q96GZ6
ProteinModelPortal	Q96GZ6	http://www.proteinmodelportal.org/query/uniprot/Q96GZ6
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
RefSeq	NP_001008485	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001008485
RefSeq	NP_001008486	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001008486
RefSeq	NP_001008487	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001008487
RefSeq	NP_001157947	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001157947
RefSeq	XP_005247619	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005247619
RefSeq	XP_005247620	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005247620
RefSeq	XP_006713744	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006713744
RefSeq	XP_016862195	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016862195
RefSeq	XP_016862196	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016862196
STRING	9606.ENSP00000326070	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000326070&targetmode=cogs
TCDB	1.A.26.2	http://www.tcdb.org/search/result.php?tc=1.A.26.2
UCSC	uc003eii	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003eii&org=rat
UniGene	Hs.573007	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.573007
UniProtKB	S41A3_HUMAN	http://www.uniprot.org/uniprot/S41A3_HUMAN
UniProtKB-AC	Q96GZ6	http://www.uniprot.org/uniprot/Q96GZ6
charge	swissprot:S41A3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S41A3_HUMAN
eggNOG	ENOG410XSTG	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSTG
eggNOG	KOG3788	http://eggnogapi.embl.de/nog_data/html/tree/KOG3788
epestfind	swissprot:S41A3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S41A3_HUMAN
garnier	swissprot:S41A3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S41A3_HUMAN
helixturnhelix	swissprot:S41A3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S41A3_HUMAN
hmoment	swissprot:S41A3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S41A3_HUMAN
iep	swissprot:S41A3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S41A3_HUMAN
inforesidue	swissprot:S41A3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S41A3_HUMAN
neXtProt	NX_Q96GZ6	http://www.nextprot.org/db/entry/NX_Q96GZ6
octanol	swissprot:S41A3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S41A3_HUMAN
pepcoil	swissprot:S41A3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S41A3_HUMAN
pepdigest	swissprot:S41A3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S41A3_HUMAN
pepinfo	swissprot:S41A3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S41A3_HUMAN
pepnet	swissprot:S41A3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S41A3_HUMAN
pepstats	swissprot:S41A3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S41A3_HUMAN
pepwheel	swissprot:S41A3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S41A3_HUMAN
pepwindow	swissprot:S41A3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S41A3_HUMAN
sigcleave	swissprot:S41A3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S41A3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AT2C1_HUMAN	Event=Alternative splicing; Named isoforms=9; Comment=Isoform 1 and isoform 2 are expressed in the same tissues.; Name=1; Synonyms=ATP2C1A; IsoId=P98194-1; Sequence=Displayed; Name=2; Synonyms=ATP2C1B, ATP2C1C; IsoId=P98194-2; Sequence=VSP_000409; Name=3; Synonyms=ATP2C1B; IsoId=P98194-3; Sequence=VSP_000408, VSP_000410; Name=4; Synonyms=ATP2C1A; IsoId=P98194-4; Sequence=VSP_000408; Name=5; Synonyms=ATP2C1B; IsoId=P98194-5; Sequence=VSP_000410; Name=6; Synonyms=ATP2C1D; IsoId=P98194-6; Sequence=VSP_014102; Name=7; IsoId=P98194-7; Sequence=VSP_045892, VSP_000410; Note=No experimental confirmation available.; Name=8; IsoId=P98194-8; Sequence=VSP_045892, VSP_055036, VSP_055037; Note=No experimental confirmation available.; Name=9; IsoId=P98194-9; Sequence=VSP_055037; Note=No experimental confirmation available.; 
# AltName	AT2C1_HUMAN	ATP-dependent Ca(2+) pump PMR1
# BRENDA	3.6.3	2681
# BioGrid	117963	15
# CATALYTIC ACTIVITY	AT2C1_HUMAN	ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2). 
# CCDS	CCDS33856	-. [P98194-9]
# CCDS	CCDS46912	-. [P98194-5]
# CCDS	CCDS46913	-. [P98194-2]
# CCDS	CCDS46914	-. [P98194-1]
# CCDS	CCDS56278	-. [P98194-7]
# CCDS	CCDS56279	-. [P98194-8]
# CCDS	CCDS56280	-. [P98194-3]
# CCDS	CCDS56281	-. [P98194-4]
# ChiTaRS	ATP2C1	human
# DISEASE	AT2C1_HUMAN	Hailey-Hailey disease (HHD) [MIM 169600]  Autosomal dominant disorder characterized by persistent blisters and suprabasal cell separation (acantholysis) of the epidermis, due to impaired keratinocyte adhesion. Patients lacking all isoforms except isoform 2 have HHD. {ECO 0000269|PubMed 10615129, ECO 0000269|PubMed 10767338, ECO 0000269|PubMed 11841554, ECO 0000269|PubMed 11874499}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00228	Enflurane
# DrugBank	DB00753	Isoflurane
# DrugBank	DB01028	Methoxyflurane
# DrugBank	DB01159	Halothane
# DrugBank	DB01189	Desflurane
# DrugBank	DB01236	Sevoflurane
# Ensembl	ENST00000328560	ENSP00000329664; ENSG00000017260. [P98194-2]
# Ensembl	ENST00000359644	ENSP00000352665; ENSG00000017260. [P98194-9]
# Ensembl	ENST00000422190	ENSP00000402677; ENSG00000017260. [P98194-5]
# Ensembl	ENST00000428331	ENSP00000395809; ENSG00000017260. [P98194-1]
# Ensembl	ENST00000504381	ENSP00000425320; ENSG00000017260. [P98194-8]
# Ensembl	ENST00000504948	ENSP00000423330; ENSG00000017260. [P98194-4]
# Ensembl	ENST00000507488	ENSP00000421326; ENSG00000017260. [P98194-7]
# Ensembl	ENST00000508532	ENSP00000424783; ENSG00000017260. [P98194-1]
# Ensembl	ENST00000510168	ENSP00000427461; ENSG00000017260. [P98194-1]
# Ensembl	ENST00000513801	ENSP00000422872; ENSG00000017260. [P98194-3]
# Ensembl	ENST00000533801	ENSP00000432956; ENSG00000017260. [P98194-2]
# ExpressionAtlas	P98194	baseline and differential
# FUNCTION	AT2C1_HUMAN	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. 
# GO_component	GO:0000139	Golgi membrane; IDA:UniProtKB.
# GO_component	GO:0005794	Golgi apparatus; IDA:UniProtKB.
# GO_component	GO:0005802	trans-Golgi network; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_function	GO:0004871	signal transducer activity; IMP:UniProtKB.
# GO_function	GO:0005388	calcium-transporting ATPase activity; IDA:UniProtKB.
# GO_function	GO:0005509	calcium ion binding; IDA:UniProtKB.
# GO_function	GO:0005524	ATP binding; IDA:UniProtKB.
# GO_function	GO:0015410	manganese-transporting ATPase activity; IDA:UniProtKB.
# GO_function	GO:0030145	manganese ion binding; IDA:UniProtKB.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0006816	calcium ion transport; IDA:UniProtKB.
# GO_process	GO:0006828	manganese ion transport; IDA:UniProtKB.
# GO_process	GO:0006874	cellular calcium ion homeostasis; IDA:UniProtKB.
# GO_process	GO:0008544	epidermis development; IMP:UniProtKB.
# GO_process	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; IMP:UniProtKB.
# GO_process	GO:0030026	cellular manganese ion homeostasis; IDA:UniProtKB.
# GO_process	GO:0031532	actin cytoskeleton reorganization; IMP:UniProtKB.
# GO_process	GO:0032468	Golgi calcium ion homeostasis; IMP:UniProtKB.
# GO_process	GO:0032472	Golgi calcium ion transport; IMP:UniProtKB.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007010	cytoskeleton organization
# GOslim_process	GO:0007155	cell adhesion
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.1110.10	-; 3.
# Genevisible	P98194	HS
# HGNC	HGNC:13211	ATP2C1
# IntAct	P98194	18
# InterPro	IPR001757	P_typ_ATPase
# InterPro	IPR004014	ATPase_P-typ_cation-transptr_N
# InterPro	IPR006068	ATPase_P-typ_cation-transptr_C
# InterPro	IPR006413	P-type_ATPase_IIA_PMR1
# InterPro	IPR008250	ATPase_P-typ_transduc_dom_A
# InterPro	IPR018303	ATPase_P-typ_P_site
# InterPro	IPR023214	HAD-like_dom
# InterPro	IPR023298	ATPase_P-typ_TM_dom
# InterPro	IPR030336	ATP2C1
# KEGG_Brite	ko01000	Enzymes
# KEGG_Disease	H00844	[Developmental disorder; Skin and connective tissue disease] Hailey-Hailey disease
# MIM	169600	phenotype
# MIM	604384	gene
# Organism	AT2C1_HUMAN	Homo sapiens (Human)
# Orphanet	2841	Familial benign chronic pemphigus
# PANTHER	PTHR24093:SF214	PTHR24093:SF214
# PRINTS	PR00120	HATPASE
# PROSITE	PS00154	ATPASE_E1_E2
# Pfam	PF00122	E1-E2_ATPase
# Pfam	PF00689	Cation_ATPase_C
# Pfam	PF00690	Cation_ATPase_N
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	AT2C1_HUMAN	Calcium-transporting ATPase type 2C member 1
# RefSeq	NP_001001485	NM_001001485.2. [P98194-2]
# RefSeq	NP_001001486	NM_001001486.1. [P98194-9]
# RefSeq	NP_001001487	NM_001001487.1. [P98194-5]
# RefSeq	NP_001186108	NM_001199179.1. [P98194-1]
# RefSeq	NP_001186109	NM_001199180.1. [P98194-7]
# RefSeq	NP_001186110	NM_001199181.1
# RefSeq	NP_001186111	NM_001199182.1. [P98194-8]
# RefSeq	NP_001186112	NM_001199183.1. [P98194-3]
# RefSeq	NP_001186113	NM_001199184.1. [P98194-4]
# RefSeq	NP_001186114	NM_001199185.1. [P98194-2]
# RefSeq	NP_055197	NM_014382.3. [P98194-1]
# RefSeq	XP_005247412	XM_005247355.2. [P98194-9]
# RefSeq	XP_005247413	XM_005247356.2. [P98194-9]
# RefSeq	XP_016861653	XM_017006164.1. [P98194-5]
# SEQUENCE CAUTION	Sequence=BAA92585.1; Type=Frameshift; Positions=8; Evidence={ECO:0000305}; Sequence=BAC11142.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. {ECO	0000305}. 
# SMART	SM00831	Cation_ATPase_N
# SUBCELLULAR LOCATION	AT2C1_HUMAN	Golgi apparatus membrane {ECO 0000269|PubMed 12707275}; Multi-pass membrane protein {ECO 0000269|PubMed 12707275}. 
# SUPFAM	SSF56784	SSF56784; 2
# TCDB	3.A.3.2	the p-type atpase (p-atpase) superfamily
# TIGRFAMs	TIGR01494	ATPase_P-type; 3
# TIGRFAMs	TIGR01522	ATPase-IIA2_Ca
# TISSUE SPECIFICITY	AT2C1_HUMAN	Found in most tissues except colon, thymus, spleen and leukocytes. Most abundant in keratinocytes and kidney. 
# UCSC	uc003enk	human. [P98194-1]
# eggNOG	COG0474	LUCA
# eggNOG	KOG0202	Eukaryota
BLAST	swissprot:AT2C1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AT2C1_HUMAN
BioCyc	ZFISH:HS00380-MONOMER	http://biocyc.org/getid?id=ZFISH:HS00380-MONOMER
COG	COG0474	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0474
COXPRESdb	27032	http://coxpresdb.jp/data/gene/27032.shtml
CleanEx	HS_ATP2C1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP2C1
DOI	10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO	http://dx.doi.org/10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/71701	http://dx.doi.org/10.1038/71701
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1046/j.0022-202x.2001.01675.x	http://dx.doi.org/10.1046/j.0022-202x.2001.01675.x
DOI	10.1046/j.0022-202x.2001.01686.x	http://dx.doi.org/10.1046/j.0022-202x.2001.01686.x
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/jbc.M300509200	http://dx.doi.org/10.1074/jbc.M300509200
DOI	10.1093/dnares/7.1.65	http://dx.doi.org/10.1093/dnares/7.1.65
DOI	10.1093/hmg/9.7.1131	http://dx.doi.org/10.1093/hmg/9.7.1131
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DrugBank	DB00228	http://www.drugbank.ca/drugs/DB00228
DrugBank	DB00753	http://www.drugbank.ca/drugs/DB00753
DrugBank	DB01028	http://www.drugbank.ca/drugs/DB01028
DrugBank	DB01159	http://www.drugbank.ca/drugs/DB01159
DrugBank	DB01189	http://www.drugbank.ca/drugs/DB01189
DrugBank	DB01236	http://www.drugbank.ca/drugs/DB01236
EC_number	EC:3.6.3.8	http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.8
EMBL	AB037768	http://www.ebi.ac.uk/ena/data/view/AB037768
EMBL	AC055733	http://www.ebi.ac.uk/ena/data/view/AC055733
EMBL	AC097105	http://www.ebi.ac.uk/ena/data/view/AC097105
EMBL	AF181120	http://www.ebi.ac.uk/ena/data/view/AF181120
EMBL	AF181121	http://www.ebi.ac.uk/ena/data/view/AF181121
EMBL	AF189723	http://www.ebi.ac.uk/ena/data/view/AF189723
EMBL	AF225981	http://www.ebi.ac.uk/ena/data/view/AF225981
EMBL	AJ010953	http://www.ebi.ac.uk/ena/data/view/AJ010953
EMBL	AK001684	http://www.ebi.ac.uk/ena/data/view/AK001684
EMBL	AK074692	http://www.ebi.ac.uk/ena/data/view/AK074692
EMBL	AK296470	http://www.ebi.ac.uk/ena/data/view/AK296470
EMBL	AK299945	http://www.ebi.ac.uk/ena/data/view/AK299945
EMBL	AK314342	http://www.ebi.ac.uk/ena/data/view/AK314342
EMBL	AY268374	http://www.ebi.ac.uk/ena/data/view/AY268374
EMBL	AY268375	http://www.ebi.ac.uk/ena/data/view/AY268375
EMBL	BC028139	http://www.ebi.ac.uk/ena/data/view/BC028139
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
ENZYME	3.6.3.8	http://enzyme.expasy.org/EC/3.6.3.8
Ensembl	ENST00000328560	http://www.ensembl.org/id/ENST00000328560
Ensembl	ENST00000359644	http://www.ensembl.org/id/ENST00000359644
Ensembl	ENST00000422190	http://www.ensembl.org/id/ENST00000422190
Ensembl	ENST00000428331	http://www.ensembl.org/id/ENST00000428331
Ensembl	ENST00000504381	http://www.ensembl.org/id/ENST00000504381
Ensembl	ENST00000504948	http://www.ensembl.org/id/ENST00000504948
Ensembl	ENST00000507488	http://www.ensembl.org/id/ENST00000507488
Ensembl	ENST00000508532	http://www.ensembl.org/id/ENST00000508532
Ensembl	ENST00000510168	http://www.ensembl.org/id/ENST00000510168
Ensembl	ENST00000513801	http://www.ensembl.org/id/ENST00000513801
Ensembl	ENST00000533801	http://www.ensembl.org/id/ENST00000533801
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005802	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005802
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GO_function	GO:0005388	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005388
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0015410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015410
GO_function	GO:0030145	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0006828	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006828
GO_process	GO:0006874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874
GO_process	GO:0008544	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008544
GO_process	GO:0016339	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016339
GO_process	GO:0030026	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030026
GO_process	GO:0031532	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031532
GO_process	GO:0032468	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032468
GO_process	GO:0032472	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032472
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0043123	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043123
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007010
GOslim_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.1110.10	http://www.cathdb.info/version/latest/superfamily/1.20.1110.10
GeneCards	ATP2C1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP2C1
GeneID	27032	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27032
GeneTree	ENSGT00850000132256	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00850000132256
HGNC	HGNC:13211	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13211
HOGENOM	HOG000265621	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265621&db=HOGENOM6
HOVERGEN	HBG106478	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG106478&db=HOVERGEN
HPA	CAB010207	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB010207
HPA	HPA035116	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035116
HPA	HPA053533	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA053533
InParanoid	P98194	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P98194
IntAct	P98194	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P98194*
IntEnz	3.6.3.8	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.8
InterPro	IPR001757	http://www.ebi.ac.uk/interpro/entry/IPR001757
InterPro	IPR004014	http://www.ebi.ac.uk/interpro/entry/IPR004014
InterPro	IPR006068	http://www.ebi.ac.uk/interpro/entry/IPR006068
InterPro	IPR006413	http://www.ebi.ac.uk/interpro/entry/IPR006413
InterPro	IPR008250	http://www.ebi.ac.uk/interpro/entry/IPR008250
InterPro	IPR018303	http://www.ebi.ac.uk/interpro/entry/IPR018303
InterPro	IPR023214	http://www.ebi.ac.uk/interpro/entry/IPR023214
InterPro	IPR023298	http://www.ebi.ac.uk/interpro/entry/IPR023298
InterPro	IPR030336	http://www.ebi.ac.uk/interpro/entry/IPR030336
Jabion	27032	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=27032
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Disease	H00844	http://www.genome.jp/dbget-bin/www_bget?H00844
KEGG_Gene	hsa:27032	http://www.genome.jp/dbget-bin/www_bget?hsa:27032
KEGG_Orthology	KO:K01537	http://www.genome.jp/dbget-bin/www_bget?KO:K01537
MIM	169600	http://www.ncbi.nlm.nih.gov/omim/169600
MIM	604384	http://www.ncbi.nlm.nih.gov/omim/604384
OMA	HRTQQDK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HRTQQDK
Orphanet	2841	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=2841
OrthoDB	EOG091G0NXU	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0NXU
PANTHER	PTHR24093:SF214	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24093:SF214
PRINTS	PR00120	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00120
PROSITE	PS00154	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00154
PSORT	swissprot:AT2C1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AT2C1_HUMAN
PSORT-B	swissprot:AT2C1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AT2C1_HUMAN
PSORT2	swissprot:AT2C1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AT2C1_HUMAN
Pfam	PF00122	http://pfam.xfam.org/family/PF00122
Pfam	PF00689	http://pfam.xfam.org/family/PF00689
Pfam	PF00690	http://pfam.xfam.org/family/PF00690
PharmGKB	PA25111	http://www.pharmgkb.org/do/serve?objId=PA25111&objCls=Gene
Phobius	swissprot:AT2C1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AT2C1_HUMAN
PhylomeDB	P98194	http://phylomedb.org/?seqid=P98194
ProteinModelPortal	P98194	http://www.proteinmodelportal.org/query/uniprot/P98194
PubMed	10615129	http://www.ncbi.nlm.nih.gov/pubmed/10615129
PubMed	10718198	http://www.ncbi.nlm.nih.gov/pubmed/10718198
PubMed	10767338	http://www.ncbi.nlm.nih.gov/pubmed/10767338
PubMed	11124703	http://www.ncbi.nlm.nih.gov/pubmed/11124703
PubMed	11841554	http://www.ncbi.nlm.nih.gov/pubmed/11841554
PubMed	11874499	http://www.ncbi.nlm.nih.gov/pubmed/11874499
PubMed	12707275	http://www.ncbi.nlm.nih.gov/pubmed/12707275
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_001001485	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001001485
RefSeq	NP_001001486	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001001486
RefSeq	NP_001001487	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001001487
RefSeq	NP_001186108	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001186108
RefSeq	NP_001186109	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001186109
RefSeq	NP_001186110	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001186110
RefSeq	NP_001186111	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001186111
RefSeq	NP_001186112	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001186112
RefSeq	NP_001186113	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001186113
RefSeq	NP_001186114	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001186114
RefSeq	NP_055197	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055197
RefSeq	XP_005247412	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005247412
RefSeq	XP_005247413	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005247413
RefSeq	XP_016861653	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016861653
SMART	SM00831	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00831
SMR	P98194	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P98194
STRING	9606.ENSP00000376914	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000376914&targetmode=cogs
STRING	COG0474	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0474&targetmode=cogs
SUPFAM	SSF56784	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784
TCDB	3.A.3.2	http://www.tcdb.org/search/result.php?tc=3.A.3.2
TIGRFAMs	TIGR01494	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01494
TIGRFAMs	TIGR01522	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01522
UCSC	uc003enk	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003enk&org=rat
UniGene	Hs.584884	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.584884
UniProtKB	AT2C1_HUMAN	http://www.uniprot.org/uniprot/AT2C1_HUMAN
UniProtKB-AC	P98194	http://www.uniprot.org/uniprot/P98194
charge	swissprot:AT2C1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AT2C1_HUMAN
eggNOG	COG0474	http://eggnogapi.embl.de/nog_data/html/tree/COG0474
eggNOG	KOG0202	http://eggnogapi.embl.de/nog_data/html/tree/KOG0202
epestfind	swissprot:AT2C1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AT2C1_HUMAN
garnier	swissprot:AT2C1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AT2C1_HUMAN
helixturnhelix	swissprot:AT2C1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AT2C1_HUMAN
hmoment	swissprot:AT2C1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AT2C1_HUMAN
iep	swissprot:AT2C1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AT2C1_HUMAN
inforesidue	swissprot:AT2C1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AT2C1_HUMAN
neXtProt	NX_P98194	http://www.nextprot.org/db/entry/NX_P98194
octanol	swissprot:AT2C1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AT2C1_HUMAN
pepcoil	swissprot:AT2C1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AT2C1_HUMAN
pepdigest	swissprot:AT2C1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AT2C1_HUMAN
pepinfo	swissprot:AT2C1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AT2C1_HUMAN
pepnet	swissprot:AT2C1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AT2C1_HUMAN
pepstats	swissprot:AT2C1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AT2C1_HUMAN
pepwheel	swissprot:AT2C1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AT2C1_HUMAN
pepwindow	swissprot:AT2C1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AT2C1_HUMAN
sigcleave	swissprot:AT2C1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AT2C1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TTYH1_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q9H313-1; Sequence=Displayed; Name=2; IsoId=Q9H313-2; Sequence=VSP_029760; Name=3; Synonyms=TTYH1s; IsoId=Q9H313-3; Sequence=VSP_029759; Name=4; IsoId=Q9H313-4; Sequence=VSP_029753, VSP_029757, VSP_029760; Note=No experimental confirmation available.; Name=5; IsoId=Q9H313-5; Sequence=VSP_029754, VSP_029755, VSP_029756, VSP_029758; Note=No experimental confirmation available.; 
# CCDS	CCDS12893	-. [Q9H313-1]
# CCDS	CCDS33106	-. [Q9H313-3]
# CCDS	CCDS56102	-. [Q9H313-2]
# CDD	cd07912	Tweety_N
# ChiTaRS	TTYH1	human
# Ensembl	ENST00000301194	ENSP00000301194; ENSG00000167614. [Q9H313-2]
# Ensembl	ENST00000376530	ENSP00000365713; ENSG00000167614. [Q9H313-1]
# Ensembl	ENST00000376531	ENSP00000365714; ENSG00000167614. [Q9H313-3]
# Ensembl	ENST00000611133	ENSP00000480177; ENSG00000276887. [Q9H313-2]
# Ensembl	ENST00000611471	ENSP00000484881; ENSG00000275650. [Q9H313-3]
# Ensembl	ENST00000611711	ENSP00000484774; ENSG00000276887. [Q9H313-1]
# Ensembl	ENST00000614387	ENSP00000484077; ENSG00000276887. [Q9H313-4]
# Ensembl	ENST00000614458	ENSP00000484835; ENSG00000276887. [Q9H313-3]
# Ensembl	ENST00000616929	ENSP00000479779; ENSG00000276537. [Q9H313-2]
# Ensembl	ENST00000619450	ENSP00000480769; ENSG00000275650. [Q9H313-1]
# Ensembl	ENST00000619453	ENSP00000484548; ENSG00000276537. [Q9H313-3]
# Ensembl	ENST00000619591	ENSP00000481601; ENSG00000275650. [Q9H313-2]
# Ensembl	ENST00000620133	ENSP00000483288; ENSG00000276887. [Q9H313-5]
# Ensembl	ENST00000620298	ENSP00000481138; ENSG00000276537. [Q9H313-1]
# Ensembl	ENST00000622771	ENSP00000482372; ENSG00000276537. [Q9H313-4]
# ExpressionAtlas	Q9H313	baseline and differential
# FUNCTION	TTYH1_HUMAN	Isoform 3 may be a Ca(2+)-independent and swelling- activated chloride channel, possibly involved in regulation of cell volume. 
# FUNCTION	TTYH1_HUMAN	Probable chloride channel. May be involved in cell adhesion (By similarity). {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; TAS:UniProtKB.
# GO_component	GO:0030868	smooth endoplasmic reticulum membrane; IEA:Ensembl.
# GO_component	GO:0031527	filopodium membrane; IEA:Ensembl.
# GO_component	GO:0032433	filopodium tip; IEA:Ensembl.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_function	GO:0005254	chloride channel activity; TAS:Reactome.
# GO_function	GO:0005381	iron ion transmembrane transporter activity; NAS:UniProtKB.
# GO_function	GO:0005509	calcium ion binding; IEA:Ensembl.
# GO_function	GO:0072320	volume-sensitive chloride channel activity; IDA:FlyBase.
# GO_process	GO:0006821	chloride transport; IDA:FlyBase.
# GO_process	GO:0006826	iron ion transport; NAS:UniProtKB.
# GO_process	GO:0007067	mitotic nuclear division; IEA:Ensembl.
# GO_process	GO:0016337	single organismal cell-cell adhesion; IEA:Ensembl.
# GO_process	GO:0031589	cell-substrate adhesion; IEA:Ensembl.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0046847	filopodium assembly; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007067	mitotic nuclear division
# GOslim_process	GO:0007155	cell adhesion
# GOslim_process	GO:0022607	cellular component assembly
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9H313	HS
# HGNC	HGNC:13476	TTYH1
# InterPro	IPR006990	Tweety
# MIM	605784	gene
# Organism	TTYH1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12424	PTHR12424
# Pfam	PF04906	Tweety
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	TTYH1_HUMAN	Protein tweety homolog 1
# RefSeq	NP_001005367	NM_001005367.2. [Q9H313-3]
# RefSeq	NP_001188390	NM_001201461.1. [Q9H313-2]
# RefSeq	NP_065710	NM_020659.3. [Q9H313-1]
# SIMILARITY	Belongs to the tweety family. {ECO	0000305}.
# SUBCELLULAR LOCATION	TTYH1_HUMAN	Cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# TCDB	1.A.48.1	the anion channel tweety (tweety) family
# TISSUE SPECIFICITY	Expressed in brain, eye, ovary and testis, and at lower levels in muscle, placenta, liver and lung. {ECO:0000269|PubMed	17116230}. 
# UCSC	uc002qfq	human. [Q9H313-1]
# eggNOG	ENOG410ZNTN	LUCA
# eggNOG	KOG4433	Eukaryota
BLAST	swissprot:TTYH1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TTYH1_HUMAN
BioCyc	ZFISH:ENSG00000167614-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000167614-MONOMER
COXPRESdb	57348	http://coxpresdb.jp/data/gene/57348.shtml
DOI	10.1006/geno.2000.6259	http://dx.doi.org/10.1006/geno.2000.6259
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M313813200	http://dx.doi.org/10.1074/jbc.M313813200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1471-4159.2006.04237.x	http://dx.doi.org/10.1111/j.1471-4159.2006.04237.x
EMBL	AB162930	http://www.ebi.ac.uk/ena/data/view/AB162930
EMBL	AB188496	http://www.ebi.ac.uk/ena/data/view/AB188496
EMBL	AF177909	http://www.ebi.ac.uk/ena/data/view/AF177909
EMBL	AK126690	http://www.ebi.ac.uk/ena/data/view/AK126690
EMBL	AK289468	http://www.ebi.ac.uk/ena/data/view/AK289468
EMBL	BC011347	http://www.ebi.ac.uk/ena/data/view/BC011347
EMBL	BC019358	http://www.ebi.ac.uk/ena/data/view/BC019358
EMBL	CH471135	http://www.ebi.ac.uk/ena/data/view/CH471135
EMBL	CH471135	http://www.ebi.ac.uk/ena/data/view/CH471135
EMBL	CU207370	http://www.ebi.ac.uk/ena/data/view/CU207370
EMBL	CU207370	http://www.ebi.ac.uk/ena/data/view/CU207370
EMBL	CU207370	http://www.ebi.ac.uk/ena/data/view/CU207370
EMBL	CU207370	http://www.ebi.ac.uk/ena/data/view/CU207370
EMBL	CU467002	http://www.ebi.ac.uk/ena/data/view/CU467002
EMBL	CU467002	http://www.ebi.ac.uk/ena/data/view/CU467002
EMBL	CU467002	http://www.ebi.ac.uk/ena/data/view/CU467002
Ensembl	ENST00000301194	http://www.ensembl.org/id/ENST00000301194
Ensembl	ENST00000376530	http://www.ensembl.org/id/ENST00000376530
Ensembl	ENST00000376531	http://www.ensembl.org/id/ENST00000376531
Ensembl	ENST00000611133	http://www.ensembl.org/id/ENST00000611133
Ensembl	ENST00000611471	http://www.ensembl.org/id/ENST00000611471
Ensembl	ENST00000611711	http://www.ensembl.org/id/ENST00000611711
Ensembl	ENST00000614387	http://www.ensembl.org/id/ENST00000614387
Ensembl	ENST00000614458	http://www.ensembl.org/id/ENST00000614458
Ensembl	ENST00000616929	http://www.ensembl.org/id/ENST00000616929
Ensembl	ENST00000619450	http://www.ensembl.org/id/ENST00000619450
Ensembl	ENST00000619453	http://www.ensembl.org/id/ENST00000619453
Ensembl	ENST00000619591	http://www.ensembl.org/id/ENST00000619591
Ensembl	ENST00000620133	http://www.ensembl.org/id/ENST00000620133
Ensembl	ENST00000620298	http://www.ensembl.org/id/ENST00000620298
Ensembl	ENST00000622771	http://www.ensembl.org/id/ENST00000622771
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030868	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030868
GO_component	GO:0031527	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031527
GO_component	GO:0032433	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032433
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0005381	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005381
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0072320	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072320
GO_process	GO:0006821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006821
GO_process	GO:0006826	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006826
GO_process	GO:0007067	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007067
GO_process	GO:0016337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016337
GO_process	GO:0031589	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031589
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0046847	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046847
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007067	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007067
GOslim_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GOslim_process	GO:0022607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	TTYH1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TTYH1
GeneID	57348	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57348
GeneTree	ENSGT00390000010182	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000010182
HGNC	HGNC:13476	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13476
HOVERGEN	HBG108621	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108621&db=HOVERGEN
HPA	HPA023617	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA023617
HPA	HPA050655	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA050655
InParanoid	Q9H313	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9H313
InterPro	IPR006990	http://www.ebi.ac.uk/interpro/entry/IPR006990
Jabion	57348	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=57348
KEGG_Gene	hsa:57348	http://www.genome.jp/dbget-bin/www_bget?hsa:57348
MIM	605784	http://www.ncbi.nlm.nih.gov/omim/605784
OMA	WISAHTW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WISAHTW
OrthoDB	EOG091G05MR	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05MR
PANTHER	PTHR12424	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12424
PSORT	swissprot:TTYH1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TTYH1_HUMAN
PSORT-B	swissprot:TTYH1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TTYH1_HUMAN
PSORT2	swissprot:TTYH1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TTYH1_HUMAN
Pfam	PF04906	http://pfam.xfam.org/family/PF04906
PharmGKB	PA37778	http://www.pharmgkb.org/do/serve?objId=PA37778&objCls=Gene
Phobius	swissprot:TTYH1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TTYH1_HUMAN
PhylomeDB	Q9H313	http://phylomedb.org/?seqid=Q9H313
ProteinModelPortal	Q9H313	http://www.proteinmodelportal.org/query/uniprot/Q9H313
PubMed	10950931	http://www.ncbi.nlm.nih.gov/pubmed/10950931
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15010458	http://www.ncbi.nlm.nih.gov/pubmed/15010458
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17116230	http://www.ncbi.nlm.nih.gov/pubmed/17116230
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_001005367	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001005367
RefSeq	NP_001188390	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001188390
RefSeq	NP_065710	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_065710
STRING	9606.ENSP00000365714	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000365714&targetmode=cogs
TCDB	1.A.48.1	http://www.tcdb.org/search/result.php?tc=1.A.48.1
UCSC	uc002qfq	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002qfq&org=rat
UniGene	Hs.268728	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.268728
UniProtKB	TTYH1_HUMAN	http://www.uniprot.org/uniprot/TTYH1_HUMAN
UniProtKB-AC	Q9H313	http://www.uniprot.org/uniprot/Q9H313
charge	swissprot:TTYH1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TTYH1_HUMAN
eggNOG	ENOG410ZNTN	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZNTN
eggNOG	KOG4433	http://eggnogapi.embl.de/nog_data/html/tree/KOG4433
epestfind	swissprot:TTYH1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TTYH1_HUMAN
garnier	swissprot:TTYH1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TTYH1_HUMAN
helixturnhelix	swissprot:TTYH1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TTYH1_HUMAN
hmoment	swissprot:TTYH1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TTYH1_HUMAN
iep	swissprot:TTYH1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TTYH1_HUMAN
inforesidue	swissprot:TTYH1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TTYH1_HUMAN
neXtProt	NX_Q9H313	http://www.nextprot.org/db/entry/NX_Q9H313
octanol	swissprot:TTYH1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TTYH1_HUMAN
pepcoil	swissprot:TTYH1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TTYH1_HUMAN
pepdigest	swissprot:TTYH1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TTYH1_HUMAN
pepinfo	swissprot:TTYH1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TTYH1_HUMAN
pepnet	swissprot:TTYH1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TTYH1_HUMAN
pepstats	swissprot:TTYH1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TTYH1_HUMAN
pepwheel	swissprot:TTYH1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TTYH1_HUMAN
pepwindow	swissprot:TTYH1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TTYH1_HUMAN
sigcleave	swissprot:TTYH1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TTYH1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SCN5A_HUMAN	Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=CAG-inclusive variant, Nav1.5c; IsoId=Q14524-1; Sequence=Displayed; Note=Most abundant isoform in heart.; Name=2; Synonyms=Nav1.5b; IsoId=Q14524-2; Sequence=VSP_037478; Note=Very abundant isoform.; Name=3; IsoId=Q14524-3; Sequence=VSP_037477, VSP_037478, VSP_037481; Name=4; Synonyms=Nav1.5e, neonatal; IsoId=Q14524-4; Sequence=VSP_037477; Note=Abundantly expressed in neonatal brain and heart, slower kinetics of activation and inactivation.; Name=5; Synonyms=Ex18del, Nav1.5a; IsoId=Q14524-5; Sequence=VSP_037477, VSP_037479; Note=Only detected in neuroblastoma in humans.; Name=6; Synonyms=Ex24del, Nav1.5f; IsoId=Q14524-6; Sequence=VSP_037477, VSP_037480; Note=High expression in brain where it accounts for nearly 50% of the total transcripts. Non-functional channel, may exist to limit the number of undesired functional Nav1.5 channels.; 
# AltName	SCN5A_HUMAN	HH1
# AltName	SCN5A_HUMAN	Sodium channel protein cardiac muscle subunit alpha
# AltName	SCN5A_HUMAN	Sodium channel protein type V subunit alpha
# AltName	SCN5A_HUMAN	Voltage-gated sodium channel subunit alpha Nav1.5
# BioGrid	112236	11
# CCDS	CCDS46796	-. [Q14524-1]
# CCDS	CCDS46797	-. [Q14524-2]
# CCDS	CCDS46798	-. [Q14524-6]
# CCDS	CCDS46799	-. [Q14524-4]
# CCDS	CCDS54569	-. [Q14524-5]
# CCDS	CCDS54570	-. [Q14524-3]
# DISEASE	SCN5A_HUMAN	Atrial fibrillation, familial, 10 (ATFB10) [MIM 614022]  A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. {ECO 0000269|PubMed 18088563, ECO 0000269|PubMed 18378609}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCN5A_HUMAN	Atrial standstill 1 (ATRST1) [MIM 108770]  A rare arrhythmia characterized by the absence of electrical and mechanical activity in the atria. Electrocardiographically, it is characterized by bradycardia, the absence of P waves, and a junctional narrow complex escape rhythm. {ECO 0000269|PubMed 12522116}. Note=The disease may be caused by mutations affecting distinct genetic loci, including the gene represented in this entry. A mutation in SCN5A has been detected in combination with a rare GJA5 genotype in a large family with atrial standstill. 
# DISEASE	SCN5A_HUMAN	Brugada syndrome 1 (BRGDA1) [MIM 601144]  A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset. {ECO 0000269|PubMed 11748104, ECO 0000269|PubMed 11901046, ECO 0000269|PubMed 12051963, ECO 0000269|PubMed 12106943, ECO 0000269|PubMed 15023552, ECO 0000269|PubMed 15338453, ECO 0000269|PubMed 15579534, ECO 0000269|PubMed 15851320, ECO 0000269|PubMed 16266370, ECO 0000269|PubMed 16325048, ECO 0000269|PubMed 16616735, ECO 0000269|PubMed 17075016, ECO 0000269|PubMed 17081365, ECO 0000269|PubMed 17198989, ECO 0000269|PubMed 18252757, ECO 0000269|PubMed 18341814, ECO 0000269|PubMed 18451998, ECO 0000269|PubMed 18456723, ECO 0000269|PubMed 18616619, ECO 0000269|PubMed 19251209, ECO 0000269|PubMed 19272188, ECO 0000269|PubMed 20129283, ECO 0000269|PubMed 23085483, ECO 0000269|PubMed 24167619, ECO 0000269|PubMed 26279430, ECO 0000269|PubMed 26776555, ECO 0000269|PubMed 9521325}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCN5A_HUMAN	Cardiomyopathy, dilated 1E (CMD1E) [MIM 601154]  A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. {ECO 0000269|PubMed 15466643}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCN5A_HUMAN	Familial paroxysmal ventricular fibrillation 1 (VF1) [MIM 603829]  A cardiac arrhythmia marked by fibrillary contractions of the ventricular muscle due to rapid repetitive excitation of myocardial fibers without coordinated contraction of the ventricle and by absence of atrial activity. {ECO 0000269|PubMed 10940383}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCN5A_HUMAN	Long QT syndrome 3 (LQT3) [MIM 603830]  A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. {ECO 0000269|PubMed 10377081, ECO 0000269|PubMed 10508990, ECO 0000269|PubMed 10627139, ECO 0000269|PubMed 10911008, ECO 0000269|PubMed 10973849, ECO 0000269|PubMed 11304498, ECO 0000269|PubMed 11997281, ECO 0000269|PubMed 12209021, ECO 0000269|PubMed 12673799, ECO 0000269|PubMed 15840476, ECO 0000269|PubMed 16414944, ECO 0000269|PubMed 16922724, ECO 0000269|PubMed 18060054, ECO 0000269|PubMed 18708744, ECO 0000269|PubMed 18848812, ECO 0000269|PubMed 18929331, ECO 0000269|PubMed 19716085, ECO 0000269|PubMed 26392562, ECO 0000269|PubMed 7651517, ECO 0000269|PubMed 7889574, ECO 0000269|PubMed 8541846, ECO 0000269|PubMed 9506831, ECO 0000269|PubMed 9686753, ECO 0000269|Ref.31}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCN5A_HUMAN	Progressive familial heart block 1A (PFHB1A) [MIM 113900]  A cardiac bundle branch disorder characterized by progressive alteration of cardiac conduction through the His- Purkinje system, with a pattern of a right bundle-branch block and/or left anterior hemiblock occurring individually or together. It leads to complete atrio-ventricular block causing syncope and sudden death. {ECO 0000269|PubMed 12569159, ECO 0000269|PubMed 12574143, ECO 0000269|PubMed 19251209}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCN5A_HUMAN	Sick sinus syndrome 1 (SSS1) [MIM 608567]  The term 'sick sinus syndrome' encompasses a variety of conditions caused by sinus node dysfunction. The most common clinical manifestations are syncope, presyncope, dizziness, and fatigue. Electrocardiogram typically shows sinus bradycardia, sinus arrest, and/or sinoatrial block. Episodes of atrial tachycardias coexisting with sinus bradycardia ('tachycardia-bradycardia syndrome') are also common in this disorder. SSS occurs most often in the elderly associated with underlying heart disease or previous cardiac surgery, but can also occur in the fetus, infant, or child without heart disease or other contributing factors. SSS1 onset is in utero, infancy, or early childhood. {ECO 0000269|PubMed 14523039, ECO 0000269|PubMed 22795782}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCN5A_HUMAN	Sudden infant death syndrome (SIDS) [MIM 272120]  SIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive. {ECO 0000269|PubMed 18596570, ECO 0000269|PubMed 19302788}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# DOMAIN	SCN5A_HUMAN	The IQ domain mediates association with calmodulin. {ECO 0000269|PubMed 21167176, ECO 0000269|PubMed 22705208}. 
# DOMAIN	SCN5A_HUMAN	The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position. 
# DrugBank	DB00192	Indecainide
# DrugBank	DB00243	Ranolazine
# DrugBank	DB00252	Phenytoin
# DrugBank	DB00280	Disopyramide
# DrugBank	DB00281	Lidocaine
# DrugBank	DB00313	Valproic Acid
# DrugBank	DB00379	Mexiletine
# DrugBank	DB00473	Hexylcaine
# DrugBank	DB00527	Cinchocaine
# DrugBank	DB00564	Carbamazepine
# DrugBank	DB00661	Verapamil
# DrugBank	DB00680	Moricizine
# DrugBank	DB00740	Riluzole
# DrugBank	DB00750	Prilocaine
# DrugBank	DB00754	Ethotoin
# DrugBank	DB00776	Oxcarbazepine
# DrugBank	DB00868	Benzonatate
# DrugBank	DB00907	Cocaine
# DrugBank	DB00908	Quinidine
# DrugBank	DB00909	Zonisamide
# DrugBank	DB01035	Procainamide
# DrugBank	DB01056	Tocainide
# DrugBank	DB01182	Propafenone
# DrugBank	DB01195	Flecainide
# DrugBank	DB01228	Encainide
# DrugBank	DB01320	Fosphenytoin
# DrugBank	DB01346	Quinidine barbiturate
# DrugBank	DB01426	Ajmaline
# DrugBank	DB01429	Aprindine
# Ensembl	ENST00000333535	ENSP00000328968; ENSG00000183873. [Q14524-1]
# Ensembl	ENST00000423572	ENSP00000398266; ENSG00000183873. [Q14524-2]
# ExpressionAtlas	Q14524	baseline and differential
# FUNCTION	SCN5A_HUMAN	This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels. {ECO 0000269|PubMed 1309946, ECO 0000269|PubMed 19074138, ECO 0000269|PubMed 23085483, ECO 0000269|PubMed 24167619, ECO 0000269|PubMed 26279430, ECO 0000269|PubMed 26392562, ECO 0000269|PubMed 26776555}. 
# GO_component	GO:0001518	voltage-gated sodium channel complex; IDA:BHF-UCL.
# GO_component	GO:0005622	intracellular; IDA:UniProtKB.
# GO_component	GO:0005783	endoplasmic reticulum; IDA:BHF-UCL.
# GO_component	GO:0005886	plasma membrane; IMP:UniProtKB.
# GO_component	GO:0005901	caveola; IDA:BHF-UCL.
# GO_component	GO:0009986	cell surface; IDA:UniProtKB.
# GO_component	GO:0014704	intercalated disc; IDA:BHF-UCL.
# GO_component	GO:0016021	integral component of membrane; IDA:UniProtKB.
# GO_component	GO:0016328	lateral plasma membrane; TAS:BHF-UCL.
# GO_component	GO:0030018	Z disc; IDA:UniProtKB.
# GO_component	GO:0030315	T-tubule; IDA:BHF-UCL.
# GO_component	GO:0042383	sarcolemma; IDA:BHF-UCL.
# GO_function	GO:0005248	voltage-gated sodium channel activity; IDA:UniProtKB.
# GO_function	GO:0005516	calmodulin binding; IPI:BHF-UCL.
# GO_function	GO:0017134	fibroblast growth factor binding; IPI:BHF-UCL.
# GO_function	GO:0019899	enzyme binding; IPI:BHF-UCL.
# GO_function	GO:0019901	protein kinase binding; IPI:BHF-UCL.
# GO_function	GO:0019904	protein domain specific binding; IPI:UniProtKB.
# GO_function	GO:0030506	ankyrin binding; IDA:BHF-UCL.
# GO_function	GO:0031625	ubiquitin protein ligase binding; IPI:BHF-UCL.
# GO_function	GO:0044325	ion channel binding; IPI:BHF-UCL.
# GO_function	GO:0050998	nitric-oxide synthase binding; IPI:BHF-UCL.
# GO_function	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential; IDA:BHF-UCL.
# GO_function	GO:0086060	voltage-gated sodium channel activity involved in AV node cell action potential; IMP:BHF-UCL.
# GO_function	GO:0086061	voltage-gated sodium channel activity involved in bundle of His cell action potential; IMP:BHF-UCL.
# GO_function	GO:0086062	voltage-gated sodium channel activity involved in Purkinje myocyte action potential; IMP:BHF-UCL.
# GO_function	GO:0086063	voltage-gated sodium channel activity involved in SA node cell action potential; IMP:BHF-UCL.
# GO_function	GO:0097110	scaffold protein binding; IPI:BHF-UCL.
# GO_process	GO:0002027	regulation of heart rate; IMP:UniProtKB.
# GO_process	GO:0003231	cardiac ventricle development; ISS:BHF-UCL.
# GO_process	GO:0003360	brainstem development; ISS:BHF-UCL.
# GO_process	GO:0006814	sodium ion transport; IDA:UniProtKB.
# GO_process	GO:0010765	positive regulation of sodium ion transport; IDA:BHF-UCL.
# GO_process	GO:0014894	response to denervation involved in regulation of muscle adaptation; ISS:BHF-UCL.
# GO_process	GO:0019228	neuronal action potential; IBA:GO_Central.
# GO_process	GO:0021537	telencephalon development; ISS:BHF-UCL.
# GO_process	GO:0021549	cerebellum development; ISS:BHF-UCL.
# GO_process	GO:0035725	sodium ion transmembrane transport; IDA:UniProtKB.
# GO_process	GO:0042475	odontogenesis of dentin-containing tooth; ISS:BHF-UCL.
# GO_process	GO:0045760	positive regulation of action potential; ISS:BHF-UCL.
# GO_process	GO:0050679	positive regulation of epithelial cell proliferation; ISS:BHF-UCL.
# GO_process	GO:0051899	membrane depolarization; IDA:BHF-UCL.
# GO_process	GO:0060048	cardiac muscle contraction; IMP:BHF-UCL.
# GO_process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization; IMP:BHF-UCL.
# GO_process	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization; IMP:BHF-UCL.
# GO_process	GO:0060372	regulation of atrial cardiac muscle cell membrane repolarization; IMP:BHF-UCL.
# GO_process	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization; IMP:BHF-UCL.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:0071277	cellular response to calcium ion; IDA:UniProtKB.
# GO_process	GO:0086002	cardiac muscle cell action potential involved in contraction; IMP:BHF-UCL.
# GO_process	GO:0086004	regulation of cardiac muscle cell contraction; IMP:BHF-UCL.
# GO_process	GO:0086005	ventricular cardiac muscle cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086010	membrane depolarization during action potential; IDA:BHF-UCL.
# GO_process	GO:0086012	membrane depolarization during cardiac muscle cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086015	SA node cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086016	AV node cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086043	bundle of His cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086045	membrane depolarization during AV node cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086046	membrane depolarization during SA node cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086047	membrane depolarization during Purkinje myocyte cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086048	membrane depolarization during bundle of His cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086067	AV node cell to bundle of His cell communication; IMP:BHF-UCL.
# GO_process	GO:0086091	regulation of heart rate by cardiac conduction; IMP:BHF-UCL.
# GO_process	GO:1902305	regulation of sodium ion transmembrane transport; IDA:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005622	intracellular
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008092	cytoskeletal protein binding
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.350	-; 4.
# Genevisible	Q14524	HS
# HGNC	HGNC:10593	SCN5A
# INTERACTION	SCN5A_HUMAN	P62158 CALM3; NbExp=2; IntAct=EBI-726858, EBI-397435; Q13557 CAMK2D; NbExp=16; IntAct=EBI-726858, EBI-351018; Q99873 PRMT1; NbExp=2; IntAct=EBI-726858, EBI-78738; O60678 PRMT3; NbExp=2; IntAct=EBI-726858, EBI-2809009; P26045 PTPN3; NbExp=2; IntAct=EBI-726858, EBI-1047946; 
# IntAct	Q14524	9
# InterPro	IPR001696	Na_channel_asu
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR008053	Na_channel_a5su
# InterPro	IPR010526	Na_trans_assoc
# InterPro	IPR024583	Na_trans_cytopl
# InterPro	IPR027359	Channel_four-helix_dom
# KEGG_Brite	ko04040	Ion channels
# KEGG_Disease	H00294	[Cardiovascular disease] Dilated cardiomyopathy (DCM)
# KEGG_Disease	H00720	[Cardiovascular disease] Jervell and Lange-Nielsen syndrome (JLNS)
# KEGG_Disease	H00728	[Cardiovascular disease] Brugada syndrome (BRS)
# KEGG_Disease	H00729	[Cardiovascular disease] Sinus node dysfunction
# KEGG_Disease	H00730	[Cardiovascular disease] Familial idiopathic ventricular fibrillation
# KEGG_Disease	H00731	[Cardiovascular disease] Atrial fibrillation
# KEGG_Disease	H01263	[Cardiovascular disease] Lenegre-Lev disease
# MIM	108770	phenotype
# MIM	113900	phenotype
# MIM	272120	phenotype
# MIM	600163	gene
# MIM	601144	phenotype
# MIM	601154	phenotype
# MIM	603829	phenotype
# MIM	603830	phenotype
# MIM	608567	phenotype
# MIM	614022	phenotype
# MISCELLANEOUS	SCN5A_HUMAN	Na(+) channels in mammalian cardiac membrane have functional properties quite distinct from Na(+) channels in nerve and skeletal muscle. 
# Organism	SCN5A_HUMAN	Homo sapiens (Human)
# Orphanet	101016	Romano-Ward syndrome
# Orphanet	130	Brugada syndrome
# Orphanet	1344	Atrial stand still
# Orphanet	154	Familial isolated dilated cardiomyopathy
# Orphanet	166282	Familial sick sinus syndrome
# Orphanet	228140	Idiopathic ventricular fibrillation, not Brugada type
# Orphanet	334	Familial atrial fibrillation
# Orphanet	871	Familial progressive cardiac conduction defect
# PDB	2KBI	NMR; -; A=1773-1865
# PDB	2L53	NMR; -; B=1901-1927
# PDB	4DCK	X-ray; 2.20 A; A=1773-1940
# PDB	4DJC	X-ray; 1.35 A; B=1491-1522
# PDB	4JQ0	X-ray; 3.84 A; D=1773-1940
# PDB	4OVN	X-ray; 2.80 A; F/G/H/I/J=1773-1929
# PIR	A38195	A38195
# PRINTS	PR00170	NACHANNEL
# PRINTS	PR01666	NACHANNEL5
# PTM	SCN5A_HUMAN	Phosphorylation at Ser-1503 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents (Probable). Regulated through phosphorylation by CaMK2D (By similarity). {ECO 0000250|UniProtKB Q9JJV9, ECO 0000305|PubMed 19666841}. 
# PTM	SCN5A_HUMAN	Ubiquitinated by NEDD4L; which promotes its endocytosis. Does not seem to be ubiquitinated by NEDD4 or WWP2. {ECO 0000269|PubMed 15217910, ECO 0000269|PubMed 15548568}. 
# Pfam	PF00520	Ion_trans; 4
# Pfam	PF06512	Na_trans_assoc
# Pfam	PF11933	Na_trans_cytopl
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-445095	Interaction between L1 and Ankyrins
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# RecName	SCN5A_HUMAN	Sodium channel protein type 5 subunit alpha
# RefSeq	NP_000326	NM_000335.4. [Q14524-2]
# RefSeq	NP_001092874	NM_001099404.1
# RefSeq	NP_001092875	NM_001099405.1
# RefSeq	NP_001153632	NM_001160160.1
# RefSeq	NP_001153633	NM_001160161.1
# RefSeq	NP_932173	NM_198056.2. [Q14524-1]
# SIMILARITY	Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.5/SCN5A subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 IQ domain. {ECO	0000305}.
# SUBCELLULAR LOCATION	SCN5A_HUMAN	Cell membrane {ECO 0000269|PubMed 1309946, ECO 0000269|PubMed 19074138, ECO 0000269|PubMed 23085483, ECO 0000269|PubMed 26279430}; Multi-pass membrane protein {ECO 0000305}. 
# SUBUNIT	SCN5A_HUMAN	Interacts with the PDZ domain of the syntrophin SNTA1, SNTB1 and SNTB2 (By similarity). Interacts with NEDD4, NEDD4L, WWP2 and GPD1L (PubMed 15217910, PubMed 15548568, PubMed 19666841). Interacts with CALM (PubMed 21167176, PubMed 22705208). Interacts with FGF13; the interaction is direct and may regulate SNC5A density at membranes and function (PubMed 21817159, PubMed 22705208, PubMed 26392562). May also interact with FGF12 and FGF14 (PubMed 26392562). {ECO 0000250|UniProtKB Q9JJV9, ECO 0000269|PubMed 15217910, ECO 0000269|PubMed 15548568, ECO 0000269|PubMed 19666841, ECO 0000269|PubMed 21167176, ECO 0000269|PubMed 21817159, ECO 0000269|PubMed 22705208, ECO 0000269|PubMed 26392562}. 
# TCDB	1.A.1.10	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	Found in jejunal circular smooth muscle cells (at protein level). Expressed in human atrial and ventricular cardiac muscle but not in adult skeletal muscle, brain, myometrium, liver, or spleen. Isoform 4 is expressed in brain. {ECO:0000269|PubMed	12358675}. 
# UCSC	uc062ihe	human. [Q14524-1]
# eggNOG	ENOG410XNP6	LUCA
# eggNOG	KOG2301	Eukaryota
BLAST	swissprot:SCN5A_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SCN5A_HUMAN
BioCyc	ZFISH:G66-32583-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32583-MONOMER
COXPRESdb	6331	http://coxpresdb.jp/data/gene/6331.shtml
CleanEx	HS_SCN5A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SCN5A
DIP	DIP-38416N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-38416N
DIP	DIP-46144N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-46144N
DOI	10.1001/jama.286.18.2264	http://dx.doi.org/10.1001/jama.286.18.2264
DOI	10.1001/jama.294.23.2975	http://dx.doi.org/10.1001/jama.294.23.2975
DOI	10.1002/(SICI)1096-8628(19991029)86:5<470::AID-AJMG13>3.0.CO	http://dx.doi.org/10.1002/(SICI)1096-8628(19991029)86:5<470::AID-AJMG13>3.0.CO
DOI	10.1002/(SICI)1098-1004(1998)12:1<72::AID-HUMU17>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1998)12:1<72::AID-HUMU17>3.0.CO
DOI	10.1002/humu.9136	http://dx.doi.org/10.1002/humu.9136
DOI	10.1007/s10038-004-0182-z	http://dx.doi.org/10.1007/s10038-004-0182-z
DOI	10.1016/0092-8674(95)90359-3	http://dx.doi.org/10.1016/0092-8674(95)90359-3
DOI	10.1016/S0008-6363(99)00350-8	http://dx.doi.org/10.1016/S0008-6363(99)00350-8
DOI	10.1016/S0014-5793(00)01875-5	http://dx.doi.org/10.1016/S0014-5793(00)01875-5
DOI	10.1016/S0014-5793(98)00033-7	http://dx.doi.org/10.1016/S0014-5793(98)00033-7
DOI	10.1016/S0140-6736(05)66786-4	http://dx.doi.org/10.1016/S0140-6736(05)66786-4
DOI	10.1016/S0735-1097(02)01962-9	http://dx.doi.org/10.1016/S0735-1097(02)01962-9
DOI	10.1016/S1096-7192(02)00006-9	http://dx.doi.org/10.1016/S1096-7192(02)00006-9
DOI	10.1016/j.arcped.2012.04.017	http://dx.doi.org/10.1016/j.arcped.2012.04.017
DOI	10.1016/j.cardiores.2004.01.022	http://dx.doi.org/10.1016/j.cardiores.2004.01.022
DOI	10.1016/j.cardiores.2006.02.030	http://dx.doi.org/10.1016/j.cardiores.2006.02.030
DOI	10.1016/j.febslet.2009.02.007	http://dx.doi.org/10.1016/j.febslet.2009.02.007
DOI	10.1016/j.hrthm.2004.11.022	http://dx.doi.org/10.1016/j.hrthm.2004.11.022
DOI	10.1016/j.hrthm.2005.01.020	http://dx.doi.org/10.1016/j.hrthm.2005.01.020
DOI	10.1016/j.hrthm.2006.09.031	http://dx.doi.org/10.1016/j.hrthm.2006.09.031
DOI	10.1016/j.hrthm.2007.09.015	http://dx.doi.org/10.1016/j.hrthm.2007.09.015
DOI	10.1016/j.hrthm.2008.07.013	http://dx.doi.org/10.1016/j.hrthm.2008.07.013
DOI	10.1016/j.hrthm.2008.08.010	http://dx.doi.org/10.1016/j.hrthm.2008.08.010
DOI	10.1016/j.hrthm.2008.11.009	http://dx.doi.org/10.1016/j.hrthm.2008.11.009
DOI	10.1016/j.hrthm.2009.05.021	http://dx.doi.org/10.1016/j.hrthm.2009.05.021
DOI	10.1016/j.hrthm.2009.09.069	http://dx.doi.org/10.1016/j.hrthm.2009.09.069
DOI	10.1016/j.hrthm.2010.11.034	http://dx.doi.org/10.1016/j.hrthm.2010.11.034
DOI	10.1016/j.hrthm.2012.10.025	http://dx.doi.org/10.1016/j.hrthm.2012.10.025
DOI	10.1016/j.hrthm.2016.01.008	http://dx.doi.org/10.1016/j.hrthm.2016.01.008
DOI	10.1016/j.jacc.2005.08.043	http://dx.doi.org/10.1016/j.jacc.2005.08.043
DOI	10.1016/j.jacc.2008.07.013	http://dx.doi.org/10.1016/j.jacc.2008.07.013
DOI	10.1016/j.jmb.2010.11.046	http://dx.doi.org/10.1016/j.jmb.2010.11.046
DOI	10.1016/j.neures.2009.04.003	http://dx.doi.org/10.1016/j.neures.2009.04.003
DOI	10.1016/j.pbiomolbio.2008.10.005	http://dx.doi.org/10.1016/j.pbiomolbio.2008.10.005
DOI	10.1016/j.str.2012.05.001	http://dx.doi.org/10.1016/j.str.2012.05.001
DOI	10.1016/j.yjmcc.2010.04.004	http://dx.doi.org/10.1016/j.yjmcc.2010.04.004
DOI	10.1016/j.ymgme.2007.10.009	http://dx.doi.org/10.1016/j.ymgme.2007.10.009
DOI	10.1021/pr200339n	http://dx.doi.org/10.1021/pr200339n
DOI	10.1021/pr300702c	http://dx.doi.org/10.1021/pr300702c
DOI	10.1038/12618	http://dx.doi.org/10.1038/12618
DOI	10.1038/32675	http://dx.doi.org/10.1038/32675
DOI	10.1038/35059090	http://dx.doi.org/10.1038/35059090
DOI	10.1038/376683a0	http://dx.doi.org/10.1038/376683a0
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1046/j.1365-2982.2002.00348.x	http://dx.doi.org/10.1046/j.1365-2982.2002.00348.x
DOI	10.1056/NEJM200007273430405	http://dx.doi.org/10.1056/NEJM200007273430405
DOI	10.1073/pnas.0403711101	http://dx.doi.org/10.1073/pnas.0403711101
DOI	10.1073/pnas.1516430112	http://dx.doi.org/10.1073/pnas.1516430112
DOI	10.1073/pnas.89.2.554	http://dx.doi.org/10.1073/pnas.89.2.554
DOI	10.1074/jbc.M104471200	http://dx.doi.org/10.1074/jbc.M104471200
DOI	10.1074/jbc.M807747200	http://dx.doi.org/10.1074/jbc.M807747200
DOI	10.1093/cvr/cvn023	http://dx.doi.org/10.1093/cvr/cvn023
DOI	10.1093/hmg/11.3.337	http://dx.doi.org/10.1093/hmg/11.3.337
DOI	10.1093/hmg/4.9.1603	http://dx.doi.org/10.1093/hmg/4.9.1603
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1365-201X.2005.01496.x	http://dx.doi.org/10.1111/j.1365-201X.2005.01496.x
DOI	10.1111/j.1399-0004.2006.00671.x	http://dx.doi.org/10.1111/j.1399-0004.2006.00671.x
DOI	10.1111/j.1460-9568.2005.04280.x	http://dx.doi.org/10.1111/j.1460-9568.2005.04280.x
DOI	10.1111/j.1748-1716.2008.01883.x	http://dx.doi.org/10.1111/j.1748-1716.2008.01883.x
DOI	10.1124/mol.114.092338	http://dx.doi.org/10.1124/mol.114.092338
DOI	10.1126/science.1073569	http://dx.doi.org/10.1126/science.1073569
DOI	10.1136/jmg.39.12.913	http://dx.doi.org/10.1136/jmg.39.12.913
DOI	10.1152/ajpcell.00460.2004	http://dx.doi.org/10.1152/ajpcell.00460.2004
DOI	10.1152/ajpgi.90571.2008	http://dx.doi.org/10.1152/ajpgi.90571.2008
DOI	10.1152/ajpheart.00513.2009	http://dx.doi.org/10.1152/ajpheart.00513.2009
DOI	10.1152/ajpheart.91495.2007	http://dx.doi.org/10.1152/ajpheart.91495.2007
DOI	10.1152/physiolgenomics.00039.2002	http://dx.doi.org/10.1152/physiolgenomics.00039.2002
DOI	10.1152/physiolgenomics.00117.2002	http://dx.doi.org/10.1152/physiolgenomics.00117.2002
DOI	10.1159/000430189	http://dx.doi.org/10.1159/000430189
DOI	10.1161/01.CIR.0000014448.19052.4C	http://dx.doi.org/10.1161/01.CIR.0000014448.19052.4C
DOI	10.1161/01.CIR.0000144458.58660.BB	http://dx.doi.org/10.1161/01.CIR.0000144458.58660.BB
DOI	10.1161/01.CIR.101.1.54	http://dx.doi.org/10.1161/01.CIR.101.1.54
DOI	10.1161/01.CIR.102.10.1178	http://dx.doi.org/10.1161/01.CIR.102.10.1178
DOI	10.1161/01.CIR.99.24.3165	http://dx.doi.org/10.1161/01.CIR.99.24.3165
DOI	10.1161/01.RES.0000050585.07097.D7	http://dx.doi.org/10.1161/01.RES.0000050585.07097.D7
DOI	10.1161/01.RES.0000052672.97759.36	http://dx.doi.org/10.1161/01.RES.0000052672.97759.36
DOI	10.1161/01.RES.0000096652.14509.96	http://dx.doi.org/10.1161/01.RES.0000096652.14509.96
DOI	10.1161/01.RES.0000136816.05109.89	http://dx.doi.org/10.1161/01.RES.0000136816.05109.89
DOI	10.1161/01.RES.83.2.141	http://dx.doi.org/10.1161/01.RES.83.2.141
DOI	10.1161/01.RES.85.12.1206	http://dx.doi.org/10.1161/01.RES.85.12.1206
DOI	10.1161/01.RES.85.9.803	http://dx.doi.org/10.1161/01.RES.85.9.803
DOI	10.1161/CIRCRESAHA.108.172619	http://dx.doi.org/10.1161/CIRCRESAHA.108.172619
DOI	10.1161/CIRCRESAHA.111.247957	http://dx.doi.org/10.1161/CIRCRESAHA.111.247957
DOI	10.1161/CIRCULATIONAHA.106.627489	http://dx.doi.org/10.1161/CIRCULATIONAHA.106.627489
DOI	10.1161/CIRCULATIONAHA.107.757955	http://dx.doi.org/10.1161/CIRCULATIONAHA.107.757955
DOI	10.1161/hc0302.102592	http://dx.doi.org/10.1161/hc0302.102592
DOI	10.1161/hc1002.105183	http://dx.doi.org/10.1161/hc1002.105183
DOI	10.1161/hc1102.105288	http://dx.doi.org/10.1161/hc1102.105288
DOI	10.1161/hc5001.100834	http://dx.doi.org/10.1161/hc5001.100834
DOI	10.1161/hh0701.089668	http://dx.doi.org/10.1161/hh0701.089668
DOI	10.1172/JCI200316879	http://dx.doi.org/10.1172/JCI200316879
DOI	10.1172/JCI200318062	http://dx.doi.org/10.1172/JCI200318062
DOI	10.1172/JCI34057	http://dx.doi.org/10.1172/JCI34057
DOI	10.1186/1423-0127-16-23	http://dx.doi.org/10.1186/1423-0127-16-23
DOI	10.1203/PDR.0b013e3181841eca	http://dx.doi.org/10.1203/PDR.0b013e3181841eca
DOI	10.1371/journal.pone.0001258	http://dx.doi.org/10.1371/journal.pone.0001258
DOI	10.1371/journal.pone.0078382	http://dx.doi.org/10.1371/journal.pone.0078382
DOI	10.4161/chan.4956	http://dx.doi.org/10.4161/chan.4956
DrugBank	DB00192	http://www.drugbank.ca/drugs/DB00192
DrugBank	DB00243	http://www.drugbank.ca/drugs/DB00243
DrugBank	DB00252	http://www.drugbank.ca/drugs/DB00252
DrugBank	DB00280	http://www.drugbank.ca/drugs/DB00280
DrugBank	DB00281	http://www.drugbank.ca/drugs/DB00281
DrugBank	DB00313	http://www.drugbank.ca/drugs/DB00313
DrugBank	DB00379	http://www.drugbank.ca/drugs/DB00379
DrugBank	DB00473	http://www.drugbank.ca/drugs/DB00473
DrugBank	DB00527	http://www.drugbank.ca/drugs/DB00527
DrugBank	DB00564	http://www.drugbank.ca/drugs/DB00564
DrugBank	DB00661	http://www.drugbank.ca/drugs/DB00661
DrugBank	DB00680	http://www.drugbank.ca/drugs/DB00680
DrugBank	DB00740	http://www.drugbank.ca/drugs/DB00740
DrugBank	DB00750	http://www.drugbank.ca/drugs/DB00750
DrugBank	DB00754	http://www.drugbank.ca/drugs/DB00754
DrugBank	DB00776	http://www.drugbank.ca/drugs/DB00776
DrugBank	DB00868	http://www.drugbank.ca/drugs/DB00868
DrugBank	DB00907	http://www.drugbank.ca/drugs/DB00907
DrugBank	DB00908	http://www.drugbank.ca/drugs/DB00908
DrugBank	DB00909	http://www.drugbank.ca/drugs/DB00909
DrugBank	DB01035	http://www.drugbank.ca/drugs/DB01035
DrugBank	DB01056	http://www.drugbank.ca/drugs/DB01056
DrugBank	DB01182	http://www.drugbank.ca/drugs/DB01182
DrugBank	DB01195	http://www.drugbank.ca/drugs/DB01195
DrugBank	DB01228	http://www.drugbank.ca/drugs/DB01228
DrugBank	DB01320	http://www.drugbank.ca/drugs/DB01320
DrugBank	DB01346	http://www.drugbank.ca/drugs/DB01346
DrugBank	DB01426	http://www.drugbank.ca/drugs/DB01426
DrugBank	DB01429	http://www.drugbank.ca/drugs/DB01429
EMBL	AB158469	http://www.ebi.ac.uk/ena/data/view/AB158469
EMBL	AB158470	http://www.ebi.ac.uk/ena/data/view/AB158470
EMBL	AB208866	http://www.ebi.ac.uk/ena/data/view/AB208866
EMBL	AF482988	http://www.ebi.ac.uk/ena/data/view/AF482988
EMBL	AP006241	http://www.ebi.ac.uk/ena/data/view/AP006241
EMBL	AY038064	http://www.ebi.ac.uk/ena/data/view/AY038064
EMBL	AY148488	http://www.ebi.ac.uk/ena/data/view/AY148488
EMBL	BC140813	http://www.ebi.ac.uk/ena/data/view/BC140813
EMBL	BC144621	http://www.ebi.ac.uk/ena/data/view/BC144621
EMBL	DQ784809	http://www.ebi.ac.uk/ena/data/view/DQ784809
EMBL	EF179185	http://www.ebi.ac.uk/ena/data/view/EF179185
EMBL	EF629346	http://www.ebi.ac.uk/ena/data/view/EF629346
EMBL	EF629347	http://www.ebi.ac.uk/ena/data/view/EF629347
EMBL	M77235	http://www.ebi.ac.uk/ena/data/view/M77235
Ensembl	ENST00000333535	http://www.ensembl.org/id/ENST00000333535
Ensembl	ENST00000423572	http://www.ensembl.org/id/ENST00000423572
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0001518	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001518
GO_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005901
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0014704	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014704
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016328
GO_component	GO:0030018	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030018
GO_component	GO:0030315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030315
GO_component	GO:0042383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042383
GO_function	GO:0005248	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005248
GO_function	GO:0005516	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005516
GO_function	GO:0017134	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017134
GO_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GO_function	GO:0019901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019901
GO_function	GO:0019904	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019904
GO_function	GO:0030506	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030506
GO_function	GO:0031625	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031625
GO_function	GO:0044325	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044325
GO_function	GO:0050998	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050998
GO_function	GO:0086006	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086006
GO_function	GO:0086060	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086060
GO_function	GO:0086061	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086061
GO_function	GO:0086062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086062
GO_function	GO:0086063	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086063
GO_function	GO:0097110	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097110
GO_process	GO:0002027	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002027
GO_process	GO:0003231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003231
GO_process	GO:0003360	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003360
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0010765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010765
GO_process	GO:0014894	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014894
GO_process	GO:0019228	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019228
GO_process	GO:0021537	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021537
GO_process	GO:0021549	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021549
GO_process	GO:0035725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035725
GO_process	GO:0042475	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042475
GO_process	GO:0045760	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045760
GO_process	GO:0050679	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050679
GO_process	GO:0051899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051899
GO_process	GO:0060048	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060048
GO_process	GO:0060307	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060307
GO_process	GO:0060371	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060371
GO_process	GO:0060372	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060372
GO_process	GO:0060373	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060373
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:0071277	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071277
GO_process	GO:0086002	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086002
GO_process	GO:0086004	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086004
GO_process	GO:0086005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086005
GO_process	GO:0086010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086010
GO_process	GO:0086012	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086012
GO_process	GO:0086015	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086015
GO_process	GO:0086016	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086016
GO_process	GO:0086043	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086043
GO_process	GO:0086045	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086045
GO_process	GO:0086046	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086046
GO_process	GO:0086047	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086047
GO_process	GO:0086048	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086048
GO_process	GO:0086067	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086067
GO_process	GO:0086091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086091
GO_process	GO:1902305	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902305
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	SCN5A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SCN5A
GeneID	6331	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6331
GeneTree	ENSGT00830000128242	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00830000128242
HGNC	HGNC:10593	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10593
HOVERGEN	HBG053100	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053100&db=HOVERGEN
InParanoid	Q14524	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q14524
IntAct	Q14524	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q14524*
InterPro	IPR001696	http://www.ebi.ac.uk/interpro/entry/IPR001696
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR008053	http://www.ebi.ac.uk/interpro/entry/IPR008053
InterPro	IPR010526	http://www.ebi.ac.uk/interpro/entry/IPR010526
InterPro	IPR024583	http://www.ebi.ac.uk/interpro/entry/IPR024583
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
Jabion	6331	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6331
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00294	http://www.genome.jp/dbget-bin/www_bget?H00294
KEGG_Disease	H00720	http://www.genome.jp/dbget-bin/www_bget?H00720
KEGG_Disease	H00728	http://www.genome.jp/dbget-bin/www_bget?H00728
KEGG_Disease	H00729	http://www.genome.jp/dbget-bin/www_bget?H00729
KEGG_Disease	H00730	http://www.genome.jp/dbget-bin/www_bget?H00730
KEGG_Disease	H00731	http://www.genome.jp/dbget-bin/www_bget?H00731
KEGG_Disease	H01263	http://www.genome.jp/dbget-bin/www_bget?H01263
KEGG_Gene	hsa:6331	http://www.genome.jp/dbget-bin/www_bget?hsa:6331
KEGG_Orthology	KO:K04838	http://www.genome.jp/dbget-bin/www_bget?KO:K04838
MIM	108770	http://www.ncbi.nlm.nih.gov/omim/108770
MIM	113900	http://www.ncbi.nlm.nih.gov/omim/113900
MIM	272120	http://www.ncbi.nlm.nih.gov/omim/272120
MIM	600163	http://www.ncbi.nlm.nih.gov/omim/600163
MIM	601144	http://www.ncbi.nlm.nih.gov/omim/601144
MIM	601154	http://www.ncbi.nlm.nih.gov/omim/601154
MIM	603829	http://www.ncbi.nlm.nih.gov/omim/603829
MIM	603830	http://www.ncbi.nlm.nih.gov/omim/603830
MIM	608567	http://www.ncbi.nlm.nih.gov/omim/608567
MIM	614022	http://www.ncbi.nlm.nih.gov/omim/614022
MINT	MINT-249922	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-249922
Orphanet	101016	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=101016
Orphanet	130	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=130
Orphanet	1344	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1344
Orphanet	154	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=154
Orphanet	166282	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=166282
Orphanet	228140	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=228140
Orphanet	334	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=334
Orphanet	871	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=871
OrthoDB	EOG091G00FK	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00FK
PDB	2KBI	http://www.ebi.ac.uk/pdbe-srv/view/entry/2KBI
PDB	2L53	http://www.ebi.ac.uk/pdbe-srv/view/entry/2L53
PDB	4DCK	http://www.ebi.ac.uk/pdbe-srv/view/entry/4DCK
PDB	4DJC	http://www.ebi.ac.uk/pdbe-srv/view/entry/4DJC
PDB	4JQ0	http://www.ebi.ac.uk/pdbe-srv/view/entry/4JQ0
PDB	4OVN	http://www.ebi.ac.uk/pdbe-srv/view/entry/4OVN
PDBsum	2KBI	http://www.ebi.ac.uk/pdbsum/2KBI
PDBsum	2L53	http://www.ebi.ac.uk/pdbsum/2L53
PDBsum	4DCK	http://www.ebi.ac.uk/pdbsum/4DCK
PDBsum	4DJC	http://www.ebi.ac.uk/pdbsum/4DJC
PDBsum	4JQ0	http://www.ebi.ac.uk/pdbsum/4JQ0
PDBsum	4OVN	http://www.ebi.ac.uk/pdbsum/4OVN
PRINTS	PR00170	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00170
PRINTS	PR01666	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01666
PSORT	swissprot:SCN5A_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SCN5A_HUMAN
PSORT-B	swissprot:SCN5A_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SCN5A_HUMAN
PSORT2	swissprot:SCN5A_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SCN5A_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF06512	http://pfam.xfam.org/family/PF06512
Pfam	PF11933	http://pfam.xfam.org/family/PF11933
PharmGKB	PA304	http://www.pharmgkb.org/do/serve?objId=PA304&objCls=Gene
Phobius	swissprot:SCN5A_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SCN5A_HUMAN
PhylomeDB	Q14524	http://phylomedb.org/?seqid=Q14524
ProteinModelPortal	Q14524	http://www.proteinmodelportal.org/query/uniprot/Q14524
PubMed	10377081	http://www.ncbi.nlm.nih.gov/pubmed/10377081
PubMed	10471492	http://www.ncbi.nlm.nih.gov/pubmed/10471492
PubMed	10508990	http://www.ncbi.nlm.nih.gov/pubmed/10508990
PubMed	10532948	http://www.ncbi.nlm.nih.gov/pubmed/10532948
PubMed	10590249	http://www.ncbi.nlm.nih.gov/pubmed/10590249
PubMed	10618304	http://www.ncbi.nlm.nih.gov/pubmed/10618304
PubMed	10627139	http://www.ncbi.nlm.nih.gov/pubmed/10627139
PubMed	10690282	http://www.ncbi.nlm.nih.gov/pubmed/10690282
PubMed	10911008	http://www.ncbi.nlm.nih.gov/pubmed/10911008
PubMed	10940383	http://www.ncbi.nlm.nih.gov/pubmed/10940383
PubMed	10973849	http://www.ncbi.nlm.nih.gov/pubmed/10973849
PubMed	11234013	http://www.ncbi.nlm.nih.gov/pubmed/11234013
PubMed	11304498	http://www.ncbi.nlm.nih.gov/pubmed/11304498
PubMed	11410597	http://www.ncbi.nlm.nih.gov/pubmed/11410597
PubMed	11710892	http://www.ncbi.nlm.nih.gov/pubmed/11710892
PubMed	11748104	http://www.ncbi.nlm.nih.gov/pubmed/11748104
PubMed	11804990	http://www.ncbi.nlm.nih.gov/pubmed/11804990
PubMed	11823453	http://www.ncbi.nlm.nih.gov/pubmed/11823453
PubMed	11889015	http://www.ncbi.nlm.nih.gov/pubmed/11889015
PubMed	11901046	http://www.ncbi.nlm.nih.gov/pubmed/11901046
PubMed	11997281	http://www.ncbi.nlm.nih.gov/pubmed/11997281
PubMed	12051963	http://www.ncbi.nlm.nih.gov/pubmed/12051963
PubMed	12106943	http://www.ncbi.nlm.nih.gov/pubmed/12106943
PubMed	12193783	http://www.ncbi.nlm.nih.gov/pubmed/12193783
PubMed	12209021	http://www.ncbi.nlm.nih.gov/pubmed/12209021
PubMed	12358675	http://www.ncbi.nlm.nih.gov/pubmed/12358675
PubMed	12454206	http://www.ncbi.nlm.nih.gov/pubmed/12454206
PubMed	12471205	http://www.ncbi.nlm.nih.gov/pubmed/12471205
PubMed	12522116	http://www.ncbi.nlm.nih.gov/pubmed/12522116
PubMed	12569159	http://www.ncbi.nlm.nih.gov/pubmed/12569159
PubMed	12574143	http://www.ncbi.nlm.nih.gov/pubmed/12574143
PubMed	12673799	http://www.ncbi.nlm.nih.gov/pubmed/12673799
PubMed	1309946	http://www.ncbi.nlm.nih.gov/pubmed/1309946
PubMed	14500339	http://www.ncbi.nlm.nih.gov/pubmed/14500339
PubMed	14523039	http://www.ncbi.nlm.nih.gov/pubmed/14523039
PubMed	15023552	http://www.ncbi.nlm.nih.gov/pubmed/15023552
PubMed	15217910	http://www.ncbi.nlm.nih.gov/pubmed/15217910
PubMed	15338453	http://www.ncbi.nlm.nih.gov/pubmed/15338453
PubMed	15466643	http://www.ncbi.nlm.nih.gov/pubmed/15466643
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15548568	http://www.ncbi.nlm.nih.gov/pubmed/15548568
PubMed	15579534	http://www.ncbi.nlm.nih.gov/pubmed/15579534
PubMed	15840476	http://www.ncbi.nlm.nih.gov/pubmed/15840476
PubMed	15851320	http://www.ncbi.nlm.nih.gov/pubmed/15851320
PubMed	16054936	http://www.ncbi.nlm.nih.gov/pubmed/16054936
PubMed	16115203	http://www.ncbi.nlm.nih.gov/pubmed/16115203
PubMed	16266370	http://www.ncbi.nlm.nih.gov/pubmed/16266370
PubMed	16325048	http://www.ncbi.nlm.nih.gov/pubmed/16325048
PubMed	16414944	http://www.ncbi.nlm.nih.gov/pubmed/16414944
PubMed	16616735	http://www.ncbi.nlm.nih.gov/pubmed/16616735
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	16922724	http://www.ncbi.nlm.nih.gov/pubmed/16922724
PubMed	17075016	http://www.ncbi.nlm.nih.gov/pubmed/17075016
PubMed	17081365	http://www.ncbi.nlm.nih.gov/pubmed/17081365
PubMed	17198989	http://www.ncbi.nlm.nih.gov/pubmed/17198989
PubMed	18060054	http://www.ncbi.nlm.nih.gov/pubmed/18060054
PubMed	18088563	http://www.ncbi.nlm.nih.gov/pubmed/18088563
PubMed	18252757	http://www.ncbi.nlm.nih.gov/pubmed/18252757
PubMed	18341814	http://www.ncbi.nlm.nih.gov/pubmed/18341814
PubMed	18368697	http://www.ncbi.nlm.nih.gov/pubmed/18368697
PubMed	18378609	http://www.ncbi.nlm.nih.gov/pubmed/18378609
PubMed	18451998	http://www.ncbi.nlm.nih.gov/pubmed/18451998
PubMed	18456723	http://www.ncbi.nlm.nih.gov/pubmed/18456723
PubMed	18596570	http://www.ncbi.nlm.nih.gov/pubmed/18596570
PubMed	18599870	http://www.ncbi.nlm.nih.gov/pubmed/18599870
PubMed	18616619	http://www.ncbi.nlm.nih.gov/pubmed/18616619
PubMed	18708744	http://www.ncbi.nlm.nih.gov/pubmed/18708744
PubMed	18848812	http://www.ncbi.nlm.nih.gov/pubmed/18848812
PubMed	18929244	http://www.ncbi.nlm.nih.gov/pubmed/18929244
PubMed	18929331	http://www.ncbi.nlm.nih.gov/pubmed/18929331
PubMed	19027780	http://www.ncbi.nlm.nih.gov/pubmed/19027780
PubMed	19056759	http://www.ncbi.nlm.nih.gov/pubmed/19056759
PubMed	19074138	http://www.ncbi.nlm.nih.gov/pubmed/19074138
PubMed	19251209	http://www.ncbi.nlm.nih.gov/pubmed/19251209
PubMed	19272188	http://www.ncbi.nlm.nih.gov/pubmed/19272188
PubMed	19302788	http://www.ncbi.nlm.nih.gov/pubmed/19302788
PubMed	19376164	http://www.ncbi.nlm.nih.gov/pubmed/19376164
PubMed	19666841	http://www.ncbi.nlm.nih.gov/pubmed/19666841
PubMed	19716085	http://www.ncbi.nlm.nih.gov/pubmed/19716085
PubMed	20129283	http://www.ncbi.nlm.nih.gov/pubmed/20129283
PubMed	20398673	http://www.ncbi.nlm.nih.gov/pubmed/20398673
PubMed	21109022	http://www.ncbi.nlm.nih.gov/pubmed/21109022
PubMed	21167176	http://www.ncbi.nlm.nih.gov/pubmed/21167176
PubMed	21726068	http://www.ncbi.nlm.nih.gov/pubmed/21726068
PubMed	21817159	http://www.ncbi.nlm.nih.gov/pubmed/21817159
PubMed	22705208	http://www.ncbi.nlm.nih.gov/pubmed/22705208
PubMed	22795782	http://www.ncbi.nlm.nih.gov/pubmed/22795782
PubMed	23085483	http://www.ncbi.nlm.nih.gov/pubmed/23085483
PubMed	23092124	http://www.ncbi.nlm.nih.gov/pubmed/23092124
PubMed	24167619	http://www.ncbi.nlm.nih.gov/pubmed/24167619
PubMed	24898004	http://www.ncbi.nlm.nih.gov/pubmed/24898004
PubMed	26279430	http://www.ncbi.nlm.nih.gov/pubmed/26279430
PubMed	26392562	http://www.ncbi.nlm.nih.gov/pubmed/26392562
PubMed	26776555	http://www.ncbi.nlm.nih.gov/pubmed/26776555
PubMed	7651517	http://www.ncbi.nlm.nih.gov/pubmed/7651517
PubMed	7889574	http://www.ncbi.nlm.nih.gov/pubmed/7889574
PubMed	8541846	http://www.ncbi.nlm.nih.gov/pubmed/8541846
PubMed	9506831	http://www.ncbi.nlm.nih.gov/pubmed/9506831
PubMed	9521325	http://www.ncbi.nlm.nih.gov/pubmed/9521325
PubMed	9686753	http://www.ncbi.nlm.nih.gov/pubmed/9686753
Reactome	R-HSA-445095	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-445095
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
RefSeq	NP_000326	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000326
RefSeq	NP_001092874	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001092874
RefSeq	NP_001092875	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001092875
RefSeq	NP_001153632	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001153632
RefSeq	NP_001153633	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001153633
RefSeq	NP_932173	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_932173
SMR	Q14524	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q14524
STRING	9606.ENSP00000328968	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000328968&targetmode=cogs
TCDB	1.A.1.10	http://www.tcdb.org/search/result.php?tc=1.A.1.10
UCSC	uc062ihe	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc062ihe&org=rat
UniGene	Hs.517898	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.517898
UniProtKB	SCN5A_HUMAN	http://www.uniprot.org/uniprot/SCN5A_HUMAN
UniProtKB-AC	Q14524	http://www.uniprot.org/uniprot/Q14524
charge	swissprot:SCN5A_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SCN5A_HUMAN
eggNOG	ENOG410XNP6	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNP6
eggNOG	KOG2301	http://eggnogapi.embl.de/nog_data/html/tree/KOG2301
epestfind	swissprot:SCN5A_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SCN5A_HUMAN
garnier	swissprot:SCN5A_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SCN5A_HUMAN
helixturnhelix	swissprot:SCN5A_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SCN5A_HUMAN
hmoment	swissprot:SCN5A_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SCN5A_HUMAN
iep	swissprot:SCN5A_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SCN5A_HUMAN
inforesidue	swissprot:SCN5A_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SCN5A_HUMAN
neXtProt	NX_Q14524	http://www.nextprot.org/db/entry/NX_Q14524
octanol	swissprot:SCN5A_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SCN5A_HUMAN
pepcoil	swissprot:SCN5A_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SCN5A_HUMAN
pepdigest	swissprot:SCN5A_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SCN5A_HUMAN
pepinfo	swissprot:SCN5A_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SCN5A_HUMAN
pepnet	swissprot:SCN5A_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SCN5A_HUMAN
pepstats	swissprot:SCN5A_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SCN5A_HUMAN
pepwheel	swissprot:SCN5A_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SCN5A_HUMAN
pepwindow	swissprot:SCN5A_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SCN5A_HUMAN
sigcleave	swissprot:SCN5A_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SCN5A_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S22A7_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9Y694-1; Sequence=Displayed; Name=2; IsoId=Q9Y694-2; Sequence=VSP_030992; Name=3; IsoId=Q9Y694-3; Sequence=VSP_030992, VSP_030994; Name=4; IsoId=Q9Y694-4; Sequence=VSP_030991, VSP_030993; 
# AltName	S22A7_HUMAN	Novel liver transporter
# AltName	S22A7_HUMAN	Organic anion transporter 2
# BIOPHYSICOCHEMICAL PROPERTIES	S22A7_HUMAN	Kinetic parameters  KM=713 nM for prostaglandin E2 {ECO 0000269|PubMed 11855680, ECO 0000269|PubMed 11907186}; KM=440 uM for tetracycline {ECO 0000269|PubMed 11855680, ECO 0000269|PubMed 11907186}; 
# CCDS	CCDS4892	-. [Q9Y694-2]
# CCDS	CCDS4893	-. [Q9Y694-1]
# CDD	cd06174	MFS
# DrugBank	DB00175	Pravastatin
# DrugBank	DB00199	Erythromycin
# DrugBank	DB00277	Theophylline
# DrugBank	DB00313	Valproic Acid
# DrugBank	DB00328	Indomethacin
# DrugBank	DB00345	Aminohippurate
# DrugBank	DB00437	Allopurinol
# DrugBank	DB00456	Cefalotin
# DrugBank	DB00493	Cefotaxime
# DrugBank	DB00495	Zidovudine
# DrugBank	DB00501	Cimetidine
# DrugBank	DB00544	Fluorouracil
# DrugBank	DB00563	Methotrexate
# DrugBank	DB00584	Enalapril
# DrugBank	DB00595	Oxytetracycline
# DrugBank	DB00624	Testosterone
# DrugBank	DB00759	Tetracycline
# DrugBank	DB00887	Bumetanide
# DrugBank	DB00917	Dinoprostone
# DrugBank	DB00936	Salicylic acid
# DrugBank	DB00943	Zalcitabine
# DrugBank	DB00945	Acetylsalicylic acid
# DrugBank	DB01004	Ganciclovir
# DrugBank	DB01009	Ketoprofen
# DrugBank	DB01016	Glyburide
# DrugBank	DB01017	Minocycline
# DrugBank	DB01032	Probenecid
# DrugBank	DB01045	Rifampicin
# DrugBank	DB01160	Dinoprost Tromethamine
# DrugBank	DB01211	Clarithromycin
# DrugBank	DB01248	Docetaxel
# DrugBank	DB01303	Oxtriphylline
# DrugBank	DB01326	Cefamandole
# DrugBank	DB01329	Cefoperazone
# DrugBank	DB02659	Cholic Acid
# Ensembl	ENST00000372574	ENSP00000361655; ENSG00000137204. [Q9Y694-3]
# Ensembl	ENST00000372585	ENSP00000361666; ENSG00000137204. [Q9Y694-1]
# Ensembl	ENST00000372589	ENSP00000361670; ENSG00000137204. [Q9Y694-2]
# ExpressionAtlas	Q9Y694	baseline and differential
# FUNCTION	S22A7_HUMAN	Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha- ketoglutarate. {ECO 0000269|PubMed 11327718, ECO 0000269|PubMed 11855680, ECO 0000269|PubMed 11907186, ECO 0000269|PubMed 12023506, ECO 0000269|PubMed 15901346}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0015347	sodium-independent organic anion transmembrane transporter activity; TAS:Reactome.
# GO_function	S22A7_HUMAN	GO 0015301 anion anion antiporter activity; TAS Reactome.
# GO_process	GO:0015711	organic anion transport; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q9Y694	HS
# HGNC	HGNC:10971	SLC22A7
# IntAct	Q9Y694	2
# InterPro	IPR004749	Orgcat_transp/SVOP
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04976	Bile secretion
# MIM	604995	gene
# Organism	S22A7_HUMAN	Homo sapiens (Human)
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-561048	Organic anion transport
# RecName	S22A7_HUMAN	Solute carrier family 22 member 7
# RefSeq	NP_006663	NM_006672.3. [Q9Y694-2]
# RefSeq	NP_696961	NM_153320.2. [Q9Y694-1]
# SIMILARITY	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S22A7_HUMAN	Basolateral cell membrane {ECO 0000269|PubMed 11907186, ECO 0000269|PubMed 12023506}; Multi- pass membrane protein {ECO 0000269|PubMed 11907186, ECO 0000269|PubMed 12023506}. Note=Apical side of the renal tubule. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.19.25	the major facilitator superfamily (mfs)
# TIGRFAMs	TIGR00898	2A0119
# TISSUE SPECIFICITY	S22A7_HUMAN	Expressed in liver and kidney. {ECO 0000269|PubMed 11327718, ECO 0000269|PubMed 11907186, ECO 0000269|PubMed 15901346}. 
# UCSC	uc003ous	human. [Q9Y694-1]
# WEB RESOURCE	S22A7_HUMAN	Name=NIEHS-SNPs; URL="http //egp.gs.washington.edu/data/slc22a7/";
# eggNOG	COG0477	LUCA
# eggNOG	KOG0255	Eukaryota
BLAST	swissprot:S22A7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S22A7_HUMAN
BioCyc	ZFISH:ENSG00000137204-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000137204-MONOMER
COXPRESdb	10864	http://coxpresdb.jp/data/gene/10864.shtml
CleanEx	HS_SLC22A7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC22A7
DOI	10.1006/bbrc.2001.4774	http://dx.doi.org/10.1006/bbrc.2001.4774
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1124/jpet.301.1.293	http://dx.doi.org/10.1124/jpet.301.1.293
DOI	10.1124/jpet.301.3.797	http://dx.doi.org/10.1124/jpet.301.3.797
DOI	10.1211/0022357055966	http://dx.doi.org/10.1211/0022357055966
DOI	10.1254/jjp.88.69	http://dx.doi.org/10.1254/jjp.88.69
DrugBank	DB00175	http://www.drugbank.ca/drugs/DB00175
DrugBank	DB00199	http://www.drugbank.ca/drugs/DB00199
DrugBank	DB00277	http://www.drugbank.ca/drugs/DB00277
DrugBank	DB00313	http://www.drugbank.ca/drugs/DB00313
DrugBank	DB00328	http://www.drugbank.ca/drugs/DB00328
DrugBank	DB00345	http://www.drugbank.ca/drugs/DB00345
DrugBank	DB00437	http://www.drugbank.ca/drugs/DB00437
DrugBank	DB00456	http://www.drugbank.ca/drugs/DB00456
DrugBank	DB00493	http://www.drugbank.ca/drugs/DB00493
DrugBank	DB00495	http://www.drugbank.ca/drugs/DB00495
DrugBank	DB00501	http://www.drugbank.ca/drugs/DB00501
DrugBank	DB00544	http://www.drugbank.ca/drugs/DB00544
DrugBank	DB00563	http://www.drugbank.ca/drugs/DB00563
DrugBank	DB00584	http://www.drugbank.ca/drugs/DB00584
DrugBank	DB00595	http://www.drugbank.ca/drugs/DB00595
DrugBank	DB00624	http://www.drugbank.ca/drugs/DB00624
DrugBank	DB00759	http://www.drugbank.ca/drugs/DB00759
DrugBank	DB00887	http://www.drugbank.ca/drugs/DB00887
DrugBank	DB00917	http://www.drugbank.ca/drugs/DB00917
DrugBank	DB00936	http://www.drugbank.ca/drugs/DB00936
DrugBank	DB00943	http://www.drugbank.ca/drugs/DB00943
DrugBank	DB00945	http://www.drugbank.ca/drugs/DB00945
DrugBank	DB01004	http://www.drugbank.ca/drugs/DB01004
DrugBank	DB01009	http://www.drugbank.ca/drugs/DB01009
DrugBank	DB01016	http://www.drugbank.ca/drugs/DB01016
DrugBank	DB01017	http://www.drugbank.ca/drugs/DB01017
DrugBank	DB01032	http://www.drugbank.ca/drugs/DB01032
DrugBank	DB01045	http://www.drugbank.ca/drugs/DB01045
DrugBank	DB01160	http://www.drugbank.ca/drugs/DB01160
DrugBank	DB01211	http://www.drugbank.ca/drugs/DB01211
DrugBank	DB01248	http://www.drugbank.ca/drugs/DB01248
DrugBank	DB01303	http://www.drugbank.ca/drugs/DB01303
DrugBank	DB01326	http://www.drugbank.ca/drugs/DB01326
DrugBank	DB01329	http://www.drugbank.ca/drugs/DB01329
DrugBank	DB02659	http://www.drugbank.ca/drugs/DB02659
EMBL	AF097518	http://www.ebi.ac.uk/ena/data/view/AF097518
EMBL	AF210455	http://www.ebi.ac.uk/ena/data/view/AF210455
EMBL	AK290796	http://www.ebi.ac.uk/ena/data/view/AK290796
EMBL	AK290806	http://www.ebi.ac.uk/ena/data/view/AK290806
EMBL	AL583834	http://www.ebi.ac.uk/ena/data/view/AL583834
EMBL	AL583834	http://www.ebi.ac.uk/ena/data/view/AL583834
EMBL	AL583834	http://www.ebi.ac.uk/ena/data/view/AL583834
EMBL	AL583834	http://www.ebi.ac.uk/ena/data/view/AL583834
EMBL	AY050498	http://www.ebi.ac.uk/ena/data/view/AY050498
EMBL	BC033805	http://www.ebi.ac.uk/ena/data/view/BC033805
EMBL	CH471081	http://www.ebi.ac.uk/ena/data/view/CH471081
EMBL	CH471081	http://www.ebi.ac.uk/ena/data/view/CH471081
EMBL	EU562669	http://www.ebi.ac.uk/ena/data/view/EU562669
Ensembl	ENST00000372574	http://www.ensembl.org/id/ENST00000372574
Ensembl	ENST00000372585	http://www.ensembl.org/id/ENST00000372585
Ensembl	ENST00000372589	http://www.ensembl.org/id/ENST00000372589
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_function	GO:0015301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015301
GO_function	GO:0015347	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015347
GO_process	GO:0015711	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015711
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC22A7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC22A7
GeneID	10864	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10864
GeneTree	ENSGT00760000118852	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118852
HGNC	HGNC:10971	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10971
HOGENOM	HOG000234569	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234569&db=HOGENOM6
HOVERGEN	HBG108433	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108433&db=HOVERGEN
HPA	HPA030220	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA030220
InParanoid	Q9Y694	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y694
IntAct	Q9Y694	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9Y694*
InterPro	IPR004749	http://www.ebi.ac.uk/interpro/entry/IPR004749
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	10864	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10864
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:10864	http://www.genome.jp/dbget-bin/www_bget?hsa:10864
KEGG_Orthology	KO:K08204	http://www.genome.jp/dbget-bin/www_bget?KO:K08204
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
MIM	604995	http://www.ncbi.nlm.nih.gov/omim/604995
OMA	HCARLNG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HCARLNG
OrthoDB	EOG091G07GO	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07GO
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:S22A7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S22A7_HUMAN
PSORT-B	swissprot:S22A7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S22A7_HUMAN
PSORT2	swissprot:S22A7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S22A7_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA35848	http://www.pharmgkb.org/do/serve?objId=PA35848&objCls=Gene
Phobius	swissprot:S22A7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S22A7_HUMAN
PhylomeDB	Q9Y694	http://phylomedb.org/?seqid=Q9Y694
ProteinModelPortal	Q9Y694	http://www.proteinmodelportal.org/query/uniprot/Q9Y694
PubMed	11327718	http://www.ncbi.nlm.nih.gov/pubmed/11327718
PubMed	11855680	http://www.ncbi.nlm.nih.gov/pubmed/11855680
PubMed	11907186	http://www.ncbi.nlm.nih.gov/pubmed/11907186
PubMed	12023506	http://www.ncbi.nlm.nih.gov/pubmed/12023506
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15901346	http://www.ncbi.nlm.nih.gov/pubmed/15901346
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
Reactome	R-HSA-561048	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-561048
RefSeq	NP_006663	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006663
RefSeq	NP_696961	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_696961
STRING	9606.ENSP00000361666	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000361666&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.19.25	http://www.tcdb.org/search/result.php?tc=2.A.1.19.25
TIGRFAMs	TIGR00898	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00898
UCSC	uc003ous	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ous&org=rat
UniGene	Hs.485438	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.485438
UniProtKB	S22A7_HUMAN	http://www.uniprot.org/uniprot/S22A7_HUMAN
UniProtKB-AC	Q9Y694	http://www.uniprot.org/uniprot/Q9Y694
charge	swissprot:S22A7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S22A7_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG0255	http://eggnogapi.embl.de/nog_data/html/tree/KOG0255
epestfind	swissprot:S22A7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S22A7_HUMAN
garnier	swissprot:S22A7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S22A7_HUMAN
helixturnhelix	swissprot:S22A7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S22A7_HUMAN
hmoment	swissprot:S22A7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S22A7_HUMAN
iep	swissprot:S22A7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S22A7_HUMAN
inforesidue	swissprot:S22A7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S22A7_HUMAN
neXtProt	NX_Q9Y694	http://www.nextprot.org/db/entry/NX_Q9Y694
octanol	swissprot:S22A7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S22A7_HUMAN
pepcoil	swissprot:S22A7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S22A7_HUMAN
pepdigest	swissprot:S22A7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S22A7_HUMAN
pepinfo	swissprot:S22A7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S22A7_HUMAN
pepnet	swissprot:S22A7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S22A7_HUMAN
pepstats	swissprot:S22A7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S22A7_HUMAN
pepwheel	swissprot:S22A7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S22A7_HUMAN
pepwindow	swissprot:S22A7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S22A7_HUMAN
sigcleave	swissprot:S22A7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S22A7_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S38AA_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9HBR0-1; Sequence=Displayed; Name=2; IsoId=Q9HBR0-2; Sequence=VSP_031324, VSP_031327; Name=3; IsoId=Q9HBR0-3; Sequence=VSP_031323, VSP_031325, VSP_031326; Note=No experimental confirmation available.; 
# AltName	S38AA_HUMAN	Solute carrier family 38 member 10
# BioGrid	125874	16
# CCDS	CCDS11780	-. [Q9HBR0-2]
# CCDS	CCDS42397	-. [Q9HBR0-1]
# ChiTaRS	SLC38A10	human
# Ensembl	ENST00000288439	ENSP00000288439; ENSG00000157637. [Q9HBR0-2]
# Ensembl	ENST00000374759	ENSP00000363891; ENSG00000157637. [Q9HBR0-1]
# ExpressionAtlas	Q9HBR0	baseline and differential
# FUNCTION	S38AA_HUMAN	Putative sodium-dependent amino acid/proton antiporter. {ECO 0000250}. 
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0003333	amino acid transmembrane transport; IBA:GO_Central.
# GO_process	GO:0006814	sodium ion transport; IEA:UniProtKB-KW.
# GO_process	GO:0060348	bone development; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9HBR0	HS
# HGNC	HGNC:28237	SLC38A10
# IntAct	Q9HBR0	10
# InterPro	IPR013057	AA_transpt_TM
# KEGG_Brite	ko02001	Solute carrier family
# MIM	616525	gene
# Organism	S38AA_HUMAN	Homo sapiens (Human)
# Pfam	PF01490	Aa_trans
# Proteomes	UP000005640	Chromosome 17
# RecName	S38AA_HUMAN	Putative sodium-coupled neutral amino acid transporter 10
# RefSeq	NP_001033073	NM_001037984.2. [Q9HBR0-1]
# RefSeq	NP_612637	NM_138570.3. [Q9HBR0-2]
# SEQUENCE CAUTION	Sequence=AAG17235.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04027.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the amino acid/polyamine transporter 2 family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S38AA_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	2.A.18.6.16	the amino acid/auxin permease (aaap) family
# UCSC	uc002jzz	human. [Q9HBR0-1]
# eggNOG	COG0814	LUCA
# eggNOG	KOG1305	Eukaryota
BLAST	swissprot:S38AA_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S38AA_HUMAN
COXPRESdb	124565	http://coxpresdb.jp/data/gene/124565.shtml
CleanEx	HS_SLC38A10	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC38A10
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0404089101	http://dx.doi.org/10.1073/pnas.0404089101
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC027601	http://www.ebi.ac.uk/ena/data/view/AC027601
EMBL	AF217993	http://www.ebi.ac.uk/ena/data/view/AF217993
EMBL	AK093037	http://www.ebi.ac.uk/ena/data/view/AK093037
EMBL	AK128330	http://www.ebi.ac.uk/ena/data/view/AK128330
EMBL	BC014642	http://www.ebi.ac.uk/ena/data/view/BC014642
EMBL	CH471099	http://www.ebi.ac.uk/ena/data/view/CH471099
Ensembl	ENST00000288439	http://www.ensembl.org/id/ENST00000288439
Ensembl	ENST00000374759	http://www.ensembl.org/id/ENST00000374759
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_process	GO:0003333	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003333
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0060348	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060348
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC38A10	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC38A10
GeneID	124565	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=124565
GeneTree	ENSGT00760000119147	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119147
HGNC	HGNC:28237	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:28237
HOGENOM	HOG000154237	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000154237&db=HOGENOM6
HOVERGEN	HBG097690	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG097690&db=HOVERGEN
HPA	HPA021374	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA021374
HPA	HPA023161	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA023161
HPA	HPA024631	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA024631
InParanoid	Q9HBR0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9HBR0
IntAct	Q9HBR0	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9HBR0*
InterPro	IPR013057	http://www.ebi.ac.uk/interpro/entry/IPR013057
Jabion	124565	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=124565
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:124565	http://www.genome.jp/dbget-bin/www_bget?hsa:124565
KEGG_Orthology	KO:K14996	http://www.genome.jp/dbget-bin/www_bget?KO:K14996
MIM	616525	http://www.ncbi.nlm.nih.gov/omim/616525
OMA	ILKEANW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ILKEANW
OrthoDB	EOG091G0IDE	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0IDE
PSORT	swissprot:S38AA_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S38AA_HUMAN
PSORT-B	swissprot:S38AA_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S38AA_HUMAN
PSORT2	swissprot:S38AA_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S38AA_HUMAN
Pfam	PF01490	http://pfam.xfam.org/family/PF01490
PharmGKB	PA162403738	http://www.pharmgkb.org/do/serve?objId=PA162403738&objCls=Gene
Phobius	swissprot:S38AA_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S38AA_HUMAN
PhylomeDB	Q9HBR0	http://phylomedb.org/?seqid=Q9HBR0
ProteinModelPortal	Q9HBR0	http://www.proteinmodelportal.org/query/uniprot/Q9HBR0
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15498874	http://www.ncbi.nlm.nih.gov/pubmed/15498874
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
RefSeq	NP_001033073	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001033073
RefSeq	NP_612637	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_612637
STRING	9606.ENSP00000363891	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000363891&targetmode=cogs
TCDB	2.A.18.6.16	http://www.tcdb.org/search/result.php?tc=2.A.18.6.16
UCSC	uc002jzz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002jzz&org=rat
UniGene	Hs.352240	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.352240
UniProtKB	S38AA_HUMAN	http://www.uniprot.org/uniprot/S38AA_HUMAN
UniProtKB-AC	Q9HBR0	http://www.uniprot.org/uniprot/Q9HBR0
charge	swissprot:S38AA_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S38AA_HUMAN
eggNOG	COG0814	http://eggnogapi.embl.de/nog_data/html/tree/COG0814
eggNOG	KOG1305	http://eggnogapi.embl.de/nog_data/html/tree/KOG1305
epestfind	swissprot:S38AA_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S38AA_HUMAN
garnier	swissprot:S38AA_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S38AA_HUMAN
helixturnhelix	swissprot:S38AA_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S38AA_HUMAN
hmoment	swissprot:S38AA_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S38AA_HUMAN
iep	swissprot:S38AA_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S38AA_HUMAN
inforesidue	swissprot:S38AA_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S38AA_HUMAN
neXtProt	NX_Q9HBR0	http://www.nextprot.org/db/entry/NX_Q9HBR0
octanol	swissprot:S38AA_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S38AA_HUMAN
pepcoil	swissprot:S38AA_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S38AA_HUMAN
pepdigest	swissprot:S38AA_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S38AA_HUMAN
pepinfo	swissprot:S38AA_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S38AA_HUMAN
pepnet	swissprot:S38AA_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S38AA_HUMAN
pepstats	swissprot:S38AA_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S38AA_HUMAN
pepwheel	swissprot:S38AA_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S38AA_HUMAN
pepwindow	swissprot:S38AA_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S38AA_HUMAN
sigcleave	swissprot:S38AA_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S38AA_HUMAN
## Database	ID	URL or Descriptions
# AltName	CALRL_HUMAN	Calcitonin receptor-like receptor
# BioGrid	115498	4
# Ensembl	ENST00000392370	ENSP00000376177; ENSG00000064989
# Ensembl	ENST00000409998	ENSP00000386972; ENSG00000064989
# Ensembl	ENST00000410068	ENSP00000387190; ENSG00000064989
# ExpressionAtlas	Q16602	baseline and differential
# FUNCTION	CALRL_HUMAN	Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. {ECO 0000250, ECO 0000269|PubMed 22102369}. 
# GO_component	GO:0005764	lysosome; IDA:UniProtKB.
# GO_component	GO:0005768	endosome; IDA:UniProtKB.
# GO_component	GO:0005783	endoplasmic reticulum; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_function	GO:0001605	adrenomedullin receptor activity; IDA:UniProtKB.
# GO_function	GO:0001635	calcitonin gene-related peptide receptor activity; IEA:Ensembl.
# GO_function	GO:0004930	G-protein coupled receptor activity; TAS:ProtInc.
# GO_function	GO:0004948	calcitonin receptor activity; IEA:InterPro.
# GO_function	GO:0008565	protein transporter activity; IDA:UniProtKB.
# GO_process	GO:0001525	angiogenesis; IDA:UniProtKB.
# GO_process	GO:0006171	cAMP biosynthetic process; IDA:UniProtKB.
# GO_process	GO:0006816	calcium ion transport; IDA:UniProtKB.
# GO_process	GO:0007166	cell surface receptor signaling pathway; IEA:InterPro.
# GO_process	GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; TAS:ProtInc.
# GO_process	GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway; IEA:Ensembl.
# GO_process	GO:0007507	heart development; IEA:Ensembl.
# GO_process	GO:0015031	protein transport; IDA:UniProtKB.
# GO_process	GO:0030819	positive regulation of cAMP biosynthetic process; IDA:UniProtKB.
# GO_process	GO:0031623	receptor internalization; IDA:UniProtKB.
# GO_process	GO:0045986	negative regulation of smooth muscle contraction; IEA:Ensembl.
# GO_process	GO:0048661	positive regulation of smooth muscle cell proliferation; IEA:Ensembl.
# GO_process	GO:0050728	negative regulation of inflammatory response; IEA:Ensembl.
# GO_process	GO:0071329	cellular response to sucrose stimulus; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005764	lysosome
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0048646	anatomical structure formation involved in morphogenesis
# GOslim_process	GO:0048856	anatomical structure development
# Genevisible	Q16602	HS
# HGNC	HGNC:16709	CALCRL
# INTERACTION	CALRL_HUMAN	P06881 CALCA; NbExp=2; IntAct=EBI-962878, EBI-962928; O60895 RAMP2; NbExp=6; IntAct=EBI-962878, EBI-9009040; 
# IntAct	Q16602	4
# InterPro	IPR000832	GPCR_2_secretin-like
# InterPro	IPR001879	GPCR_2_extracellular_dom
# InterPro	IPR003287	GCPR_2_calcitonin_rcpt_fam
# InterPro	IPR003289	GPCR_2_CGRP1_rcpt
# InterPro	IPR017981	GPCR_2-like
# InterPro	IPR017983	GPCR_2_secretin-like_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04030	 G protein-coupled receptors
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04270	Vascular smooth muscle contraction
# MIM	114190	gene
# Organism	CALRL_HUMAN	Homo sapiens (Human)
# PDB	3AQF	X-ray; 2.60 A; B=23-136
# PDB	3N7P	X-ray; 2.80 A; A/B/C/J=23-133
# PDB	3N7R	X-ray; 2.90 A; A/B=23-133
# PDB	3N7S	X-ray; 2.10 A; A/B=23-133
# PDB	4RWF	X-ray; 1.76 A; A=31-116
# PDB	4RWG	X-ray; 2.44 A; A/B/C=31-114
# PIR	JC2477	JC2477
# PRINTS	PR00249	GPCRSECRETIN
# PRINTS	PR01350	CTRFAMILY
# PRINTS	PR01351	CGRPRECEPTOR
# PROSITE	PS00649	G_PROTEIN_RECEP_F2_1
# PROSITE	PS00650	G_PROTEIN_RECEP_F2_2
# PROSITE	PS50227	G_PROTEIN_RECEP_F2_3
# PROSITE	PS50261	G_PROTEIN_RECEP_F2_4
# Pfam	PF00002	7tm_2
# Pfam	PF02793	HRM
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-418555	G alpha (s) signalling events
# Reactome	R-HSA-419812	Calcitonin-like ligand receptors
# RecName	CALRL_HUMAN	Calcitonin gene-related peptide type 1 receptor
# RefSeq	NP_001258680	NM_001271751.1
# RefSeq	NP_005786	NM_005795.5
# SEQUENCE CAUTION	Sequence=BAF84319.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the G-protein coupled receptor 2 family. {ECO	0000305}. 
# SMART	SM00008	HormR
# SUBCELLULAR LOCATION	CALRL_HUMAN	Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	CALRL_HUMAN	Heterodimer of CALCRL and RAMP3 (By similarity). Heterodimer of CALCRL and RAMP1 or CALCRL and RAMP2. {ECO 0000250, ECO 0000269|PubMed 20826335, ECO 0000269|PubMed 22102369}. 
# TCDB	9.A.14.4.12	the g-protein-coupled receptor (gpcr) family
# TISSUE SPECIFICITY	CALRL_HUMAN	Predominantly expressed in the lung and heart. 
# UCSC	uc002upv	human
# eggNOG	ENOG410XRS2	LUCA
# eggNOG	KOG4564	Eukaryota
BLAST	swissprot:CALRL_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CALRL_HUMAN
BioCyc	ZFISH:ENSG00000064989-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000064989-MONOMER
COXPRESdb	10203	http://coxpresdb.jp/data/gene/10203.shtml
CleanEx	HS_CALCRL	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CALCRL
DIP	DIP-37674N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-37674N
DOI	10.1002/pro.2003	http://dx.doi.org/10.1002/pro.2003
DOI	10.1006/bbrc.1995.1047	http://dx.doi.org/10.1006/bbrc.1995.1047
DOI	10.1016/j.str.2010.05.014	http://dx.doi.org/10.1016/j.str.2010.05.014
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.271.19.11325	http://dx.doi.org/10.1074/jbc.271.19.11325
DOI	10.1110/ps.04682504	http://dx.doi.org/10.1110/ps.04682504
EMBL	AC007319	http://www.ebi.ac.uk/ena/data/view/AC007319
EMBL	AC074020	http://www.ebi.ac.uk/ena/data/view/AC074020
EMBL	AK291630	http://www.ebi.ac.uk/ena/data/view/AK291630
EMBL	AK292998	http://www.ebi.ac.uk/ena/data/view/AK292998
EMBL	AY389506	http://www.ebi.ac.uk/ena/data/view/AY389506
EMBL	L76380	http://www.ebi.ac.uk/ena/data/view/L76380
EMBL	U17473	http://www.ebi.ac.uk/ena/data/view/U17473
Ensembl	ENST00000392370	http://www.ensembl.org/id/ENST00000392370
Ensembl	ENST00000409998	http://www.ensembl.org/id/ENST00000409998
Ensembl	ENST00000410068	http://www.ensembl.org/id/ENST00000410068
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GO_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0001605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001605
GO_function	GO:0001635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001635
GO_function	GO:0004930	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004930
GO_function	GO:0004948	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004948
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0001525	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001525
GO_process	GO:0006171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006171
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0007166	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007166
GO_process	GO:0007187	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007187
GO_process	GO:0007189	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007189
GO_process	GO:0007507	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007507
GO_process	GO:0015031	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031
GO_process	GO:0030819	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030819
GO_process	GO:0031623	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031623
GO_process	GO:0045986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045986
GO_process	GO:0048661	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048661
GO_process	GO:0050728	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050728
GO_process	GO:0071329	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071329
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0048646	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048646
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GeneCards	CALCRL	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CALCRL
GeneID	10203	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10203
HGNC	HGNC:16709	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16709
HOVERGEN	HBG102129	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG102129&db=HOVERGEN
HPA	HPA008070	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA008070
InParanoid	Q16602	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q16602
IntAct	Q16602	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q16602*
InterPro	IPR000832	http://www.ebi.ac.uk/interpro/entry/IPR000832
InterPro	IPR001879	http://www.ebi.ac.uk/interpro/entry/IPR001879
InterPro	IPR003287	http://www.ebi.ac.uk/interpro/entry/IPR003287
InterPro	IPR003289	http://www.ebi.ac.uk/interpro/entry/IPR003289
InterPro	IPR017981	http://www.ebi.ac.uk/interpro/entry/IPR017981
InterPro	IPR017983	http://www.ebi.ac.uk/interpro/entry/IPR017983
Jabion	10203	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10203
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04030	http://www.genome.jp/dbget-bin/www_bget?ko04030
KEGG_Gene	hsa:10203	http://www.genome.jp/dbget-bin/www_bget?hsa:10203
KEGG_Orthology	KO:K04577	http://www.genome.jp/dbget-bin/www_bget?KO:K04577
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04270	http://www.genome.jp/kegg-bin/show_pathway?ko04270
MIM	114190	http://www.ncbi.nlm.nih.gov/omim/114190
OrthoDB	EOG091G027C	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G027C
PDB	3AQF	http://www.ebi.ac.uk/pdbe-srv/view/entry/3AQF
PDB	3N7P	http://www.ebi.ac.uk/pdbe-srv/view/entry/3N7P
PDB	3N7R	http://www.ebi.ac.uk/pdbe-srv/view/entry/3N7R
PDB	3N7S	http://www.ebi.ac.uk/pdbe-srv/view/entry/3N7S
PDB	4RWF	http://www.ebi.ac.uk/pdbe-srv/view/entry/4RWF
PDB	4RWG	http://www.ebi.ac.uk/pdbe-srv/view/entry/4RWG
PDBsum	3AQF	http://www.ebi.ac.uk/pdbsum/3AQF
PDBsum	3N7P	http://www.ebi.ac.uk/pdbsum/3N7P
PDBsum	3N7R	http://www.ebi.ac.uk/pdbsum/3N7R
PDBsum	3N7S	http://www.ebi.ac.uk/pdbsum/3N7S
PDBsum	4RWF	http://www.ebi.ac.uk/pdbsum/4RWF
PDBsum	4RWG	http://www.ebi.ac.uk/pdbsum/4RWG
PRINTS	PR00249	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00249
PRINTS	PR01350	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01350
PRINTS	PR01351	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01351
PROSITE	PS00649	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00649
PROSITE	PS00650	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00650
PROSITE	PS50227	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50227
PROSITE	PS50261	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50261
PSORT	swissprot:CALRL_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CALRL_HUMAN
PSORT-B	swissprot:CALRL_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CALRL_HUMAN
PSORT2	swissprot:CALRL_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CALRL_HUMAN
Pfam	PF00002	http://pfam.xfam.org/family/PF00002
Pfam	PF02793	http://pfam.xfam.org/family/PF02793
PharmGKB	PA26033	http://www.pharmgkb.org/do/serve?objId=PA26033&objCls=Gene
Phobius	swissprot:CALRL_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CALRL_HUMAN
PhylomeDB	Q16602	http://phylomedb.org/?seqid=Q16602
ProteinModelPortal	Q16602	http://www.proteinmodelportal.org/query/uniprot/Q16602
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15340161	http://www.ncbi.nlm.nih.gov/pubmed/15340161
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	20826335	http://www.ncbi.nlm.nih.gov/pubmed/20826335
PubMed	22102369	http://www.ncbi.nlm.nih.gov/pubmed/22102369
PubMed	7818539	http://www.ncbi.nlm.nih.gov/pubmed/7818539
PubMed	8626685	http://www.ncbi.nlm.nih.gov/pubmed/8626685
Reactome	R-HSA-418555	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418555
Reactome	R-HSA-419812	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-419812
RefSeq	NP_001258680	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001258680
RefSeq	NP_005786	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005786
SMART	SM00008	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00008
SMR	Q16602	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q16602
STRING	9606.ENSP00000376177	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000376177&targetmode=cogs
TCDB	9.A.14.4.12	http://www.tcdb.org/search/result.php?tc=9.A.14.4.12
UCSC	uc002upv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002upv&org=rat
UniGene	Hs.470882	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.470882
UniGene	Hs.744587	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.744587
UniProtKB	CALRL_HUMAN	http://www.uniprot.org/uniprot/CALRL_HUMAN
UniProtKB-AC	Q16602	http://www.uniprot.org/uniprot/Q16602
charge	swissprot:CALRL_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CALRL_HUMAN
eggNOG	ENOG410XRS2	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRS2
eggNOG	KOG4564	http://eggnogapi.embl.de/nog_data/html/tree/KOG4564
epestfind	swissprot:CALRL_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CALRL_HUMAN
garnier	swissprot:CALRL_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CALRL_HUMAN
helixturnhelix	swissprot:CALRL_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CALRL_HUMAN
hmoment	swissprot:CALRL_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CALRL_HUMAN
iep	swissprot:CALRL_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CALRL_HUMAN
inforesidue	swissprot:CALRL_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CALRL_HUMAN
neXtProt	NX_Q16602	http://www.nextprot.org/db/entry/NX_Q16602
octanol	swissprot:CALRL_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CALRL_HUMAN
pepcoil	swissprot:CALRL_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CALRL_HUMAN
pepdigest	swissprot:CALRL_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CALRL_HUMAN
pepinfo	swissprot:CALRL_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CALRL_HUMAN
pepnet	swissprot:CALRL_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CALRL_HUMAN
pepstats	swissprot:CALRL_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CALRL_HUMAN
pepwheel	swissprot:CALRL_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CALRL_HUMAN
pepwindow	swissprot:CALRL_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CALRL_HUMAN
sigcleave	swissprot:CALRL_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CALRL_HUMAN
## Database	ID	URL or Descriptions
# AltName	LRC8C_HUMAN	Factor for adipocyte differentiation 158
# AltName	LRC8C_HUMAN	Leucine-rich repeat-containing protein 8C
# BioGrid	123963	7
# ChiTaRS	LRRC8C	human
# Ensembl	ENST00000370454	ENSP00000359483; ENSG00000171488
# ExpressionAtlas	Q8TDW0	baseline and differential
# FUNCTION	LRC8C_HUMAN	Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. {ECO 0000269|PubMed 24790029, ECO 0000269|PubMed 26824658}. 
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005789	endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IMP:UniProtKB.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_function	GO:0005225	volume-sensitive anion channel activity; IMP:UniProtKB.
# GO_process	GO:0045444	fat cell differentiation; IEA:Ensembl.
# GO_process	GO:0098656	anion transmembrane transport; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.80.10.10	-; 1.
# Genevisible	Q8TDW0	HS
# HGNC	HGNC:25075	LRRC8C
# InterPro	IPR001611	Leu-rich_rpt
# InterPro	IPR003591	Leu-rich_rpt_typical-subtyp
# InterPro	IPR021040	LRRC8_Pannexin-like
# InterPro	IPR026906	LRR_5
# InterPro	IPR032675	L_dom-like
# KEGG_Disease	H00085	[Primary immunodeficiency] Leucine-rich repeat-containing 8
# MIM	612889	gene
# Organism	LRC8C_HUMAN	Homo sapiens (Human)
# PROSITE	PS51450	LRR; 7
# Pfam	PF12534	Pannexin_like
# Pfam	PF13306	LRR_5
# Pfam	PF13855	LRR_8
# Proteomes	UP000005640	Chromosome 1
# RecName	LRC8C_HUMAN	Volume-regulated anion channel subunit LRRC8C
# RefSeq	NP_115646	NM_032270.4
# RefSeq	XP_011540584	XM_011542282.2
# RefSeq	XP_016857992	XM_017002503.1
# SIMILARITY	Belongs to the LRRC8 family. {ECO	0000305}. 
# SIMILARITY	Contains 17 LRR (leucine-rich) repeats. {ECO	0000305}.
# SMART	SM00369	LRR_TYP; 7
# SUBCELLULAR LOCATION	LRC8C_HUMAN	Cell membrane {ECO 0000269|PubMed 24790029}; Multi-pass membrane protein {ECO 0000305}. Endoplasmic reticulum membrane {ECO 0000305|PubMed 24790029}. Note=In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum. Requires LRRC8A for expression at the cell membrane. {ECO 0000269|PubMed 24790029}. 
# SUBUNIT	LRC8C_HUMAN	Heterooligomer; heterooligomerizes with other LRRC8 proteins (LRRC8A, LRRC8B, LRRC8D and/or LRRC8E), possibly to form a heterohexamer (PubMed 24790029, PubMed 26824658). In vivo, the subunit composition may depend primarily on expression levels, and heterooligomeric channels containing various proportions of the different LRRC8 proteins may coexist (Probable). {ECO 0000269|PubMed 24790029, ECO 0000269|PubMed 26824658, ECO 0000305}. 
# SUPFAM	SSF52058	SSF52058
# TCDB	1.A.25.3	the gap junction-forming innexin (innexin) family
# TISSUE SPECIFICITY	Expressed at highest levels in skeletal muscle, and at moderate levels in heart, lung and peripheral blood leukocytes. {ECO:0000269|PubMed	15564382}. 
# UCSC	uc001dnl	human
# eggNOG	COG4886	LUCA
# eggNOG	KOG0619	Eukaryota
BLAST	swissprot:LRC8C_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:LRC8C_HUMAN
BioCyc	ZFISH:ENSG00000171488-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000171488-MONOMER
COXPRESdb	84230	http://coxpresdb.jp/data/gene/84230.shtml
CleanEx	HS_LRRC8C	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_LRRC8C
DIP	DIP-61362N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-61362N
DOI	10.1002/bies.201100173	http://dx.doi.org/10.1002/bies.201100173
DOI	10.1016/j.cell.2015.12.031	http://dx.doi.org/10.1016/j.cell.2015.12.031
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1101/gr.GR1547R	http://dx.doi.org/10.1101/gr.GR1547R
DOI	10.1126/science.1252826	http://dx.doi.org/10.1126/science.1252826
DOI	10.1242/jcs.01546	http://dx.doi.org/10.1242/jcs.01546
EMBL	AB081509	http://www.ebi.ac.uk/ena/data/view/AB081509
EMBL	AC093423	http://www.ebi.ac.uk/ena/data/view/AC093423
EMBL	AK127881	http://www.ebi.ac.uk/ena/data/view/AK127881
EMBL	AL136919	http://www.ebi.ac.uk/ena/data/view/AL136919
EMBL	BC113973	http://www.ebi.ac.uk/ena/data/view/BC113973
Ensembl	ENST00000370454	http://www.ensembl.org/id/ENST00000370454
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0005225	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005225
GO_process	GO:0045444	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045444
GO_process	GO:0098656	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098656
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.80.10.10	http://www.cathdb.info/version/latest/superfamily/3.80.10.10
GeneCards	LRRC8C	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=LRRC8C
GeneID	84230	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84230
GeneTree	ENSGT00840000129676	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00840000129676
HGNC	HGNC:25075	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:25075
HOGENOM	HOG000231806	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231806&db=HOGENOM6
HOVERGEN	HBG052360	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052360&db=HOVERGEN
HPA	HPA029347	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA029347
InParanoid	Q8TDW0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8TDW0
InterPro	IPR001611	http://www.ebi.ac.uk/interpro/entry/IPR001611
InterPro	IPR003591	http://www.ebi.ac.uk/interpro/entry/IPR003591
InterPro	IPR021040	http://www.ebi.ac.uk/interpro/entry/IPR021040
InterPro	IPR026906	http://www.ebi.ac.uk/interpro/entry/IPR026906
InterPro	IPR032675	http://www.ebi.ac.uk/interpro/entry/IPR032675
Jabion	84230	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=84230
KEGG_Disease	H00085	http://www.genome.jp/dbget-bin/www_bget?H00085
KEGG_Gene	hsa:84230	http://www.genome.jp/dbget-bin/www_bget?hsa:84230
MIM	612889	http://www.ncbi.nlm.nih.gov/omim/612889
MINT	MINT-4721599	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4721599
OMA	NEWTADK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NEWTADK
OrthoDB	EOG091G01ER	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01ER
PROSITE	PS51450	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51450
PSORT	swissprot:LRC8C_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:LRC8C_HUMAN
PSORT-B	swissprot:LRC8C_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:LRC8C_HUMAN
PSORT2	swissprot:LRC8C_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:LRC8C_HUMAN
Pfam	PF12534	http://pfam.xfam.org/family/PF12534
Pfam	PF13306	http://pfam.xfam.org/family/PF13306
Pfam	PF13855	http://pfam.xfam.org/family/PF13855
PharmGKB	PA142671536	http://www.pharmgkb.org/do/serve?objId=PA142671536&objCls=Gene
Phobius	swissprot:LRC8C_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:LRC8C_HUMAN
PhylomeDB	Q8TDW0	http://phylomedb.org/?seqid=Q8TDW0
ProteinModelPortal	Q8TDW0	http://www.proteinmodelportal.org/query/uniprot/Q8TDW0
PubMed	11230166	http://www.ncbi.nlm.nih.gov/pubmed/11230166
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15564382	http://www.ncbi.nlm.nih.gov/pubmed/15564382
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	22532330	http://www.ncbi.nlm.nih.gov/pubmed/22532330
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24790029	http://www.ncbi.nlm.nih.gov/pubmed/24790029
PubMed	26824658	http://www.ncbi.nlm.nih.gov/pubmed/26824658
RefSeq	NP_115646	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_115646
RefSeq	XP_011540584	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011540584
RefSeq	XP_016857992	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016857992
SMART	SM00369	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00369
STRING	9606.ENSP00000359483	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000359483&targetmode=cogs
SUPFAM	SSF52058	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52058
TCDB	1.A.25.3	http://www.tcdb.org/search/result.php?tc=1.A.25.3
UCSC	uc001dnl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001dnl&org=rat
UniGene	Hs.412836	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.412836
UniProtKB	LRC8C_HUMAN	http://www.uniprot.org/uniprot/LRC8C_HUMAN
UniProtKB-AC	Q8TDW0	http://www.uniprot.org/uniprot/Q8TDW0
charge	swissprot:LRC8C_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:LRC8C_HUMAN
eggNOG	COG4886	http://eggnogapi.embl.de/nog_data/html/tree/COG4886
eggNOG	KOG0619	http://eggnogapi.embl.de/nog_data/html/tree/KOG0619
epestfind	swissprot:LRC8C_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:LRC8C_HUMAN
garnier	swissprot:LRC8C_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:LRC8C_HUMAN
helixturnhelix	swissprot:LRC8C_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:LRC8C_HUMAN
hmoment	swissprot:LRC8C_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:LRC8C_HUMAN
iep	swissprot:LRC8C_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:LRC8C_HUMAN
inforesidue	swissprot:LRC8C_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:LRC8C_HUMAN
neXtProt	NX_Q8TDW0	http://www.nextprot.org/db/entry/NX_Q8TDW0
octanol	swissprot:LRC8C_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:LRC8C_HUMAN
pepcoil	swissprot:LRC8C_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:LRC8C_HUMAN
pepdigest	swissprot:LRC8C_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:LRC8C_HUMAN
pepinfo	swissprot:LRC8C_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:LRC8C_HUMAN
pepnet	swissprot:LRC8C_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:LRC8C_HUMAN
pepstats	swissprot:LRC8C_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:LRC8C_HUMAN
pepwheel	swissprot:LRC8C_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:LRC8C_HUMAN
pepwindow	swissprot:LRC8C_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:LRC8C_HUMAN
sigcleave	swissprot:LRC8C_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:LRC8C_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S19A2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O60779-1; Sequence=Displayed; Name=2; IsoId=O60779-2; Sequence=VSP_036467; 
# AltName	S19A2_HUMAN	Solute carrier family 19 member 2
# AltName	S19A2_HUMAN	Thiamine carrier 1
# BioGrid	115811	30
# CCDS	CCDS1280	-. [O60779-1]
# CCDS	CCDS81398	-. [O60779-2]
# ChiTaRS	SLC19A2	human
# DISEASE	S19A2_HUMAN	Thiamine-responsive megaloblastic anemia syndrome (TRMA) [MIM 249270]  An autosomal recessive disease characterized by megaloblastic anemia, diabetes mellitus, and sensorineural deafness. Onset is typically between infancy and adolescence, but all of the cardinal findings are often not present initially. The anemia, and sometimes the diabetes, improves with high doses of thiamine. Other more variable features include optic atrophy, congenital heart defects, short stature, and stroke. {ECO 0000269|PubMed 10391221, ECO 0000269|PubMed 10874303}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00152	Thiamine
# Ensembl	ENST00000236137	ENSP00000236137; ENSG00000117479. [O60779-1]
# Ensembl	ENST00000367804	ENSP00000356778; ENSG00000117479. [O60779-2]
# ExpressionAtlas	O60779	baseline and differential
# FUNCTION	S19A2_HUMAN	High-affinity transporter for the intake of thiamine. 
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_function	GO:0008517	folic acid transporter activity; NAS:UniProtKB.
# GO_function	GO:0015234	thiamine transmembrane transporter activity; TAS:UniProtKB.
# GO_function	GO:0015403	thiamine uptake transmembrane transporter activity; IDA:UniProtKB.
# GO_process	GO:0015888	thiamine transport; NAS:UniProtKB.
# GO_process	GO:0042723	thiamine-containing compound metabolic process; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006790	sulfur compound metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# Genevisible	O60779	HS
# HGNC	HGNC:10938	SLC19A2
# InterPro	IPR002666	Folate_carrier
# InterPro	IPR020846	MFS_dom
# InterPro	IPR028338	ThTr-1
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H01183	[Inherited metabolic disease] Thiamine-responsive megaloblastic anemia (TRMA)
# KEGG_Disease	H01565	[Metabolic disorders; Nervous system disease] Wernicke-Korsakoff syndrome
# KEGG_Pathway	ko04977	Vitamin digestion and absorption
# MIM	249270	phenotype
# MIM	603941	gene
# Organism	S19A2_HUMAN	Homo sapiens (Human)
# Orphanet	49827	Thiamine-responsive megaloblastic anemia syndrome
# PANTHER	PTHR10686	PTHR10686
# PIRSF	PIRSF028739	Folate_carrier
# PIRSF	PIRSF500794	Thiamine_transporter_1
# Pfam	PF01770	Folate_carrier
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-196819	Vitamin B1 (thiamin) metabolism
# RecName	S19A2_HUMAN	Thiamine transporter 1
# RefSeq	NP_001306596	NM_001319667.1. [O60779-2]
# RefSeq	NP_008927	NM_006996.2. [O60779-1]
# SEQUENCE CAUTION	Sequence=BAG64936.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S19A2_HUMAN	Membrane; Multi-pass membrane protein. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.48.1	the reduced folate carrier (rfc) family
# TISSUE SPECIFICITY	S19A2_HUMAN	Ubiquitous; most abundant in skeletal and cardiac muscle. Medium expression in placenta, heart, liver and kidney, low in lung. 
# UCSC	uc001gge	human. [O60779-1]
# eggNOG	ENOG410XT34	LUCA
# eggNOG	KOG3810	Eukaryota
BLAST	swissprot:S19A2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S19A2_HUMAN
BioCyc	ZFISH:ENSG00000117479-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000117479-MONOMER
COXPRESdb	10560	http://coxpresdb.jp/data/gene/10560.shtml
CleanEx	HS_SLC19A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC19A2
DOI	10.1002/1098-1004(200007)16:1<37::AID-HUMU7>3.0.CO	http://dx.doi.org/10.1002/1098-1004(200007)16:1<37::AID-HUMU7>3.0.CO
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/10372	http://dx.doi.org/10.1038/10372
DOI	10.1038/10379	http://dx.doi.org/10.1038/10379
DOI	10.1038/10385	http://dx.doi.org/10.1038/10385
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1074/jbc.274.45.31925	http://dx.doi.org/10.1074/jbc.274.45.31925
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00152	http://www.drugbank.ca/drugs/DB00152
EMBL	AF135488	http://www.ebi.ac.uk/ena/data/view/AF135488
EMBL	AF153330	http://www.ebi.ac.uk/ena/data/view/AF153330
EMBL	AF158233	http://www.ebi.ac.uk/ena/data/view/AF158233
EMBL	AF160186	http://www.ebi.ac.uk/ena/data/view/AF160186
EMBL	AF160756	http://www.ebi.ac.uk/ena/data/view/AF160756
EMBL	AF160812	http://www.ebi.ac.uk/ena/data/view/AF160812
EMBL	AF272359	http://www.ebi.ac.uk/ena/data/view/AF272359
EMBL	AJ237724	http://www.ebi.ac.uk/ena/data/view/AJ237724
EMBL	AJ238413	http://www.ebi.ac.uk/ena/data/view/AJ238413
EMBL	AK304021	http://www.ebi.ac.uk/ena/data/view/AK304021
EMBL	AK313779	http://www.ebi.ac.uk/ena/data/view/AK313779
EMBL	AK316465	http://www.ebi.ac.uk/ena/data/view/AK316465
EMBL	AL021068	http://www.ebi.ac.uk/ena/data/view/AL021068
EMBL	AL021068	http://www.ebi.ac.uk/ena/data/view/AL021068
EMBL	BC018514	http://www.ebi.ac.uk/ena/data/view/BC018514
EMBL	CH471067	http://www.ebi.ac.uk/ena/data/view/CH471067
EMBL	CH471067	http://www.ebi.ac.uk/ena/data/view/CH471067
Ensembl	ENST00000236137	http://www.ensembl.org/id/ENST00000236137
Ensembl	ENST00000367804	http://www.ensembl.org/id/ENST00000367804
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0008517	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008517
GO_function	GO:0015234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015234
GO_function	GO:0015403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015403
GO_process	GO:0015888	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015888
GO_process	GO:0042723	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042723
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GeneCards	SLC19A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC19A2
GeneID	10560	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10560
GeneTree	ENSGT00510000046382	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00510000046382
HGNC	HGNC:10938	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10938
HOVERGEN	HBG054198	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054198&db=HOVERGEN
HPA	HPA006119	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA006119
HPA	HPA016599	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA016599
InParanoid	O60779	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O60779
IntAct	O60779	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O60779*
InterPro	IPR002666	http://www.ebi.ac.uk/interpro/entry/IPR002666
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
InterPro	IPR028338	http://www.ebi.ac.uk/interpro/entry/IPR028338
Jabion	10560	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10560
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H01183	http://www.genome.jp/dbget-bin/www_bget?H01183
KEGG_Disease	H01565	http://www.genome.jp/dbget-bin/www_bget?H01565
KEGG_Gene	hsa:10560	http://www.genome.jp/dbget-bin/www_bget?hsa:10560
KEGG_Orthology	KO:K14610	http://www.genome.jp/dbget-bin/www_bget?KO:K14610
KEGG_Pathway	ko04977	http://www.genome.jp/kegg-bin/show_pathway?ko04977
MIM	249270	http://www.ncbi.nlm.nih.gov/omim/249270
MIM	603941	http://www.ncbi.nlm.nih.gov/omim/603941
OMA	VCYSSRP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VCYSSRP
Orphanet	49827	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=49827
OrthoDB	EOG091G0BSJ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0BSJ
PANTHER	PTHR10686	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10686
PSORT	swissprot:S19A2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S19A2_HUMAN
PSORT-B	swissprot:S19A2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S19A2_HUMAN
PSORT2	swissprot:S19A2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S19A2_HUMAN
Pfam	PF01770	http://pfam.xfam.org/family/PF01770
PharmGKB	PA35825	http://www.pharmgkb.org/do/serve?objId=PA35825&objCls=Gene
Phobius	swissprot:S19A2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S19A2_HUMAN
PhylomeDB	O60779	http://phylomedb.org/?seqid=O60779
ProteinModelPortal	O60779	http://www.proteinmodelportal.org/query/uniprot/O60779
PubMed	10391221	http://www.ncbi.nlm.nih.gov/pubmed/10391221
PubMed	10391222	http://www.ncbi.nlm.nih.gov/pubmed/10391222
PubMed	10391223	http://www.ncbi.nlm.nih.gov/pubmed/10391223
PubMed	10542220	http://www.ncbi.nlm.nih.gov/pubmed/10542220
PubMed	10874303	http://www.ncbi.nlm.nih.gov/pubmed/10874303
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
Reactome	R-HSA-196819	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-196819
RefSeq	NP_001306596	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001306596
RefSeq	NP_008927	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_008927
STRING	9606.ENSP00000236137	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000236137&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.48.1	http://www.tcdb.org/search/result.php?tc=2.A.48.1
UCSC	uc001gge	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001gge&org=rat
UniGene	Hs.30246	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.30246
UniProtKB	S19A2_HUMAN	http://www.uniprot.org/uniprot/S19A2_HUMAN
UniProtKB-AC	O60779	http://www.uniprot.org/uniprot/O60779
charge	swissprot:S19A2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S19A2_HUMAN
eggNOG	ENOG410XT34	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XT34
eggNOG	KOG3810	http://eggnogapi.embl.de/nog_data/html/tree/KOG3810
epestfind	swissprot:S19A2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S19A2_HUMAN
garnier	swissprot:S19A2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S19A2_HUMAN
helixturnhelix	swissprot:S19A2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S19A2_HUMAN
hmoment	swissprot:S19A2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S19A2_HUMAN
iep	swissprot:S19A2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S19A2_HUMAN
inforesidue	swissprot:S19A2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S19A2_HUMAN
neXtProt	NX_O60779	http://www.nextprot.org/db/entry/NX_O60779
octanol	swissprot:S19A2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S19A2_HUMAN
pepcoil	swissprot:S19A2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S19A2_HUMAN
pepdigest	swissprot:S19A2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S19A2_HUMAN
pepinfo	swissprot:S19A2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S19A2_HUMAN
pepnet	swissprot:S19A2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S19A2_HUMAN
pepstats	swissprot:S19A2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S19A2_HUMAN
pepwheel	swissprot:S19A2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S19A2_HUMAN
pepwindow	swissprot:S19A2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S19A2_HUMAN
sigcleave	swissprot:S19A2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S19A2_HUMAN
## Database	ID	URL or Descriptions
# AltName	QCR8_HUMAN	Complex III subunit 8
# AltName	QCR8_HUMAN	Complex III subunit VIII
# AltName	QCR8_HUMAN	Ubiquinol-cytochrome c reductase complex 9.5 kDa protein
# AltName	QCR8_HUMAN	Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C
# BioGrid	117991	82
# ChiTaRS	UQCRQ	human
# DISEASE	QCR8_HUMAN	Mitochondrial complex III deficiency, nuclear 4 (MC3DN4) [MIM 615159]  A disorder of the mitochondrial respiratory chain resulting in a highly variable phenotype depending on which tissues are affected. Clinical features include mitochondrial encephalopathy, psychomotor retardation, ataxia, severe failure to thrive, liver dysfunction, renal tubulopathy, muscle weakness and exercise intolerance. {ECO 0000269|PubMed 18439546}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000378665	ENSP00000367934; ENSG00000164405
# Ensembl	ENST00000378667	ENSP00000367936; ENSG00000164405
# Ensembl	ENST00000378670	ENSP00000367939; ENSG00000164405
# FUNCTION	QCR8_HUMAN	This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone. 
# GO_component	GO:0005739	mitochondrion; IDA:HPA.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0005750	mitochondrial respiratory chain complex III; IBA:GO_Central.
# GO_function	GO:0008121	ubiquinol-cytochrome-c reductase activity; IEA:InterPro.
# GO_process	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c; IBA:GO_Central.
# GO_process	GO:0021539	subthalamus development; IEA:Ensembl.
# GO_process	GO:0021548	pons development; IEA:Ensembl.
# GO_process	GO:0021680	cerebellar Purkinje cell layer development; IEA:Ensembl.
# GO_process	GO:0021766	hippocampus development; IEA:Ensembl.
# GO_process	GO:0021794	thalamus development; IEA:Ensembl.
# GO_process	GO:0021854	hypothalamus development; IEA:Ensembl.
# GO_process	GO:0021860	pyramidal neuron development; IEA:Ensembl.
# GO_process	GO:0030901	midbrain development; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# GOslim_process	GO:0048856	anatomical structure development
# Gene3D	1.20.5.210	-; 1.
# Genevisible	O14949	HS
# HGNC	HGNC:29594	UQCRQ
# IntAct	O14949	14
# InterPro	IPR004205	Cyt_bc1_su8
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Disease	H00473	[Inherited metabolic disease; Mitochondrial disease] GRACILE Syndrome
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	612080	gene
# MIM	615159	phenotype
# Organism	QCR8_HUMAN	Homo sapiens (Human)
# Orphanet	1460	Isolated CoQ-cytochrome C reductase deficiency
# PANTHER	PTHR12119	PTHR12119
# Pfam	PF02939	UcrQ
# ProDom	PD331499	UcrQ
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-611105	Respiratory electron transport
# RecName	QCR8_HUMAN	Cytochrome b-c1 complex subunit 8
# RefSeq	NP_055217	NM_014402.4
# SIMILARITY	Belongs to the UQCRQ/QCR8 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	QCR8_HUMAN	Mitochondrion inner membrane. 
# SUBUNIT	The bc1 complex contains 11 subunits	 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1). 
# SUPFAM	SSF81508	SSF81508
# UCSC	uc003kya	human
# eggNOG	ENOG41123BH	LUCA
# eggNOG	KOG4116	Eukaryota
BLAST	swissprot:QCR8_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:QCR8_HUMAN
BioCyc	ZFISH:HS09077-MONOMER	http://biocyc.org/getid?id=ZFISH:HS09077-MONOMER
COXPRESdb	27089	http://coxpresdb.jp/data/gene/27089.shtml
CleanEx	HS_UQCRQ	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_UQCRQ
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/0076-6879(95)60132-5	http://dx.doi.org/10.1016/0076-6879(95)60132-5
DOI	10.1016/j.ajhg.2008.03.020	http://dx.doi.org/10.1016/j.ajhg.2008.03.020
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	BC001390	http://www.ebi.ac.uk/ena/data/view/BC001390
EMBL	BC090048	http://www.ebi.ac.uk/ena/data/view/BC090048
EMBL	D50369	http://www.ebi.ac.uk/ena/data/view/D50369
Ensembl	ENST00000378665	http://www.ensembl.org/id/ENST00000378665
Ensembl	ENST00000378667	http://www.ensembl.org/id/ENST00000378667
Ensembl	ENST00000378670	http://www.ensembl.org/id/ENST00000378670
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005750	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005750
GO_function	GO:0008121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008121
GO_process	GO:0006122	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006122
GO_process	GO:0021539	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021539
GO_process	GO:0021548	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021548
GO_process	GO:0021680	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021680
GO_process	GO:0021766	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021766
GO_process	GO:0021794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021794
GO_process	GO:0021854	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021854
GO_process	GO:0021860	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021860
GO_process	GO:0030901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030901
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
Gene3D	1.20.5.210	http://www.cathdb.info/version/latest/superfamily/1.20.5.210
GeneCards	UQCRQ	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=UQCRQ
GeneID	27089	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27089
GeneTree	ENSGT00390000004029	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000004029
HGNC	HGNC:29594	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:29594
HOGENOM	HOG000205681	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000205681&db=HOGENOM6
HOVERGEN	HBG001468	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG001468&db=HOVERGEN
HPA	HPA046693	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA046693
HPA	HPA053323	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA053323
InParanoid	O14949	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O14949
IntAct	O14949	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O14949*
InterPro	IPR004205	http://www.ebi.ac.uk/interpro/entry/IPR004205
Jabion	27089	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=27089
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Disease	H00473	http://www.genome.jp/dbget-bin/www_bget?H00473
KEGG_Gene	hsa:27089	http://www.genome.jp/dbget-bin/www_bget?hsa:27089
KEGG_Orthology	KO:K00418	http://www.genome.jp/dbget-bin/www_bget?KO:K00418
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	612080	http://www.ncbi.nlm.nih.gov/omim/612080
MIM	615159	http://www.ncbi.nlm.nih.gov/omim/615159
MINT	MINT-1417930	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1417930
OMA	ILNGAHF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ILNGAHF
Orphanet	1460	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1460
OrthoDB	EOG091G13Z0	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G13Z0
PANTHER	PTHR12119	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12119
PSORT	swissprot:QCR8_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:QCR8_HUMAN
PSORT-B	swissprot:QCR8_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:QCR8_HUMAN
PSORT2	swissprot:QCR8_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:QCR8_HUMAN
Pfam	PF02939	http://pfam.xfam.org/family/PF02939
PharmGKB	PA142670637	http://www.pharmgkb.org/do/serve?objId=PA142670637&objCls=Gene
Phobius	swissprot:QCR8_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:QCR8_HUMAN
PhylomeDB	O14949	http://phylomedb.org/?seqid=O14949
ProteinModelPortal	O14949	http://www.proteinmodelportal.org/query/uniprot/O14949
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18439546	http://www.ncbi.nlm.nih.gov/pubmed/18439546
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	8592474	http://www.ncbi.nlm.nih.gov/pubmed/8592474
Reactome	R-HSA-611105	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-611105
RefSeq	NP_055217	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055217
SMR	O14949	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O14949
STRING	9606.ENSP00000367934	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000367934&targetmode=cogs
SUPFAM	SSF81508	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81508
UCSC	uc003kya	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003kya&org=rat
UniGene	Hs.146602	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.146602
UniProtKB	QCR8_HUMAN	http://www.uniprot.org/uniprot/QCR8_HUMAN
UniProtKB-AC	O14949	http://www.uniprot.org/uniprot/O14949
charge	swissprot:QCR8_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:QCR8_HUMAN
eggNOG	ENOG41123BH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG41123BH
eggNOG	KOG4116	http://eggnogapi.embl.de/nog_data/html/tree/KOG4116
epestfind	swissprot:QCR8_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:QCR8_HUMAN
garnier	swissprot:QCR8_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:QCR8_HUMAN
helixturnhelix	swissprot:QCR8_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:QCR8_HUMAN
hmoment	swissprot:QCR8_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:QCR8_HUMAN
iep	swissprot:QCR8_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:QCR8_HUMAN
inforesidue	swissprot:QCR8_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:QCR8_HUMAN
neXtProt	NX_O14949	http://www.nextprot.org/db/entry/NX_O14949
octanol	swissprot:QCR8_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:QCR8_HUMAN
pepcoil	swissprot:QCR8_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:QCR8_HUMAN
pepdigest	swissprot:QCR8_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:QCR8_HUMAN
pepinfo	swissprot:QCR8_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:QCR8_HUMAN
pepnet	swissprot:QCR8_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:QCR8_HUMAN
pepstats	swissprot:QCR8_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:QCR8_HUMAN
pepwheel	swissprot:QCR8_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:QCR8_HUMAN
pepwindow	swissprot:QCR8_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:QCR8_HUMAN
sigcleave	swissprot:QCR8_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:QCR8_HUMAN
## Database	ID	URL or Descriptions
# AltName	S13A4_HUMAN	Na(+)/sulfate cotransporter SUT-1
# AltName	S13A4_HUMAN	NaS2
# ChiTaRS	SLC13A4	human
# Ensembl	ENST00000354042	ENSP00000297282; ENSG00000164707
# ExpressionAtlas	Q9UKG4	baseline and differential
# FUNCTION	S13A4_HUMAN	Sodium/sulfate cotransporter that mediates sulfate reabsorption in the high endothelial venules (HEV). {ECO 0000269|PubMed 10535998, ECO 0000269|PubMed 15607730}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_function	S13A4_HUMAN	GO 0015382 sodium sulfate symporter activity; TAS Reactome.
# GO_process	GO:0008272	sulfate transport; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q9UKG4	HS
# HGNC	HGNC:15827	SLC13A4
# InterPro	IPR001898	Na/sul_symport
# KEGG_Brite	ko02001	Solute carrier family
# MIM	604309	gene
# MISCELLANEOUS	S13A4_HUMAN	Transport is inhibited by thiosulfate, phosphate, molybdate, selenate and tungstate. Not inhibited by oxalate, citrate, succinate, phenol red or 4,4'-diisothiocyanostilbene- 2,2'-disulfonic acid (DIDS). 
# Organism	S13A4_HUMAN	Homo sapiens (Human)
# Pfam	PF00939	Na_sulph_symp
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-433137	Sodium-coupled sulphate, di- and tri-carboxylate transporters
# RecName	S13A4_HUMAN	Solute carrier family 13 member 4
# RefSeq	NP_001305121	NM_001318192.1
# RefSeq	NP_036582	NM_012450.3
# SIMILARITY	Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	S13A4_HUMAN	Membrane; Multi-pass membrane protein. 
# TCDB	2.A.47.1.14:the divalent anion	na(+) symporter (dass) family
# TISSUE SPECIFICITY	S13A4_HUMAN	Highly expressed in placenta and testis with intermediate levels in brain and lower levels in heart, thymus and liver. {ECO 0000269|PubMed 10535998, ECO 0000269|PubMed 15607730}. 
# UCSC	uc003vta	human
# eggNOG	COG0471	LUCA
# eggNOG	KOG1281	Eukaryota
BLAST	swissprot:S13A4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S13A4_HUMAN
BioCyc	ZFISH:ENSG00000164707-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000164707-MONOMER
COXPRESdb	26266	http://coxpresdb.jp/data/gene/26266.shtml
CleanEx	HS_SLC13A4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC13A4
DOI	10.1016/j.bbrc.2004.11.102	http://dx.doi.org/10.1016/j.bbrc.2004.11.102
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1073/pnas.96.22.12772	http://dx.doi.org/10.1073/pnas.96.22.12772
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1083423	http://dx.doi.org/10.1126/science.1083423
EMBL	AC091736	http://www.ebi.ac.uk/ena/data/view/AC091736
EMBL	AF169301	http://www.ebi.ac.uk/ena/data/view/AF169301
EMBL	BC030689	http://www.ebi.ac.uk/ena/data/view/BC030689
EMBL	CH236950	http://www.ebi.ac.uk/ena/data/view/CH236950
EMBL	CH471070	http://www.ebi.ac.uk/ena/data/view/CH471070
Ensembl	ENST00000354042	http://www.ensembl.org/id/ENST00000354042
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0015382	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015382
GO_process	GO:0008272	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008272
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC13A4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC13A4
GeneID	26266	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26266
GeneTree	ENSGT00550000074480	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074480
H-InvDB	HIX0025275	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0025275
HGNC	HGNC:15827	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:15827
HOGENOM	HOG000278432	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278432&db=HOGENOM6
HOVERGEN	HBG055339	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG055339&db=HOVERGEN
HPA	HPA048582	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA048582
InParanoid	Q9UKG4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UKG4
InterPro	IPR001898	http://www.ebi.ac.uk/interpro/entry/IPR001898
Jabion	26266	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=26266
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:26266	http://www.genome.jp/dbget-bin/www_bget?hsa:26266
KEGG_Orthology	KO:K14444	http://www.genome.jp/dbget-bin/www_bget?KO:K14444
MIM	604309	http://www.ncbi.nlm.nih.gov/omim/604309
OMA	IFVNEDT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IFVNEDT
OrthoDB	EOG091G092X	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G092X
PSORT	swissprot:S13A4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S13A4_HUMAN
PSORT-B	swissprot:S13A4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S13A4_HUMAN
PSORT2	swissprot:S13A4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S13A4_HUMAN
Pfam	PF00939	http://pfam.xfam.org/family/PF00939
PharmGKB	PA38045	http://www.pharmgkb.org/do/serve?objId=PA38045&objCls=Gene
Phobius	swissprot:S13A4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S13A4_HUMAN
PhylomeDB	Q9UKG4	http://phylomedb.org/?seqid=Q9UKG4
ProteinModelPortal	Q9UKG4	http://www.proteinmodelportal.org/query/uniprot/Q9UKG4
PubMed	10535998	http://www.ncbi.nlm.nih.gov/pubmed/10535998
PubMed	12690205	http://www.ncbi.nlm.nih.gov/pubmed/12690205
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15607730	http://www.ncbi.nlm.nih.gov/pubmed/15607730
Reactome	R-HSA-433137	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-433137
RefSeq	NP_001305121	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001305121
RefSeq	NP_036582	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_036582
STRING	9606.ENSP00000297282	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000297282&targetmode=cogs
TCDB	2.A.47.1.14	http://www.tcdb.org/search/result.php?tc=2.A.47.1.14
UCSC	uc003vta	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003vta&org=rat
UniGene	Hs.490241	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.490241
UniProtKB	S13A4_HUMAN	http://www.uniprot.org/uniprot/S13A4_HUMAN
UniProtKB-AC	Q9UKG4	http://www.uniprot.org/uniprot/Q9UKG4
charge	swissprot:S13A4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S13A4_HUMAN
eggNOG	COG0471	http://eggnogapi.embl.de/nog_data/html/tree/COG0471
eggNOG	KOG1281	http://eggnogapi.embl.de/nog_data/html/tree/KOG1281
epestfind	swissprot:S13A4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S13A4_HUMAN
garnier	swissprot:S13A4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S13A4_HUMAN
helixturnhelix	swissprot:S13A4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S13A4_HUMAN
hmoment	swissprot:S13A4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S13A4_HUMAN
iep	swissprot:S13A4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S13A4_HUMAN
inforesidue	swissprot:S13A4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S13A4_HUMAN
neXtProt	NX_Q9UKG4	http://www.nextprot.org/db/entry/NX_Q9UKG4
octanol	swissprot:S13A4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S13A4_HUMAN
pepcoil	swissprot:S13A4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S13A4_HUMAN
pepdigest	swissprot:S13A4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S13A4_HUMAN
pepinfo	swissprot:S13A4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S13A4_HUMAN
pepnet	swissprot:S13A4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S13A4_HUMAN
pepstats	swissprot:S13A4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S13A4_HUMAN
pepwheel	swissprot:S13A4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S13A4_HUMAN
pepwindow	swissprot:S13A4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S13A4_HUMAN
sigcleave	swissprot:S13A4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S13A4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GBRB3_HUMAN	Event=Alternative splicing; Named isoforms=4; Comment=Isoforms differ in their signal region.; Name=1; IsoId=P28472-1; Sequence=Displayed; Name=2; IsoId=P28472-2; Sequence=VSP_000088; Note=Variant in position  11 P->S (in ECA5, the mutant protein is hyperglycosylated and has reduced mean current densities compared to wild-type, dbSNP rs25409). Variant in position  15 S->F (in ECA5, the mutant protein is hyperglycosylated and has reduced mean current densities compared to wild-type). {ECO 0000269|PubMed 18514161}; Name=3; IsoId=P28472-3; Sequence=VSP_046126; Note=No experimental confirmation available.; Name=4; IsoId=P28472-4; Sequence=VSP_046676; 
# AltName	GBRB3_HUMAN	GABA(A) receptor subunit beta-3
# BioGrid	108836	9
# CCDS	CCDS10018	-. [P28472-2]
# CCDS	CCDS10019	-. [P28472-1]
# CCDS	CCDS53920	-. [P28472-4]
# CCDS	CCDS53921	-. [P28472-3]
# ChiTaRS	GABRB3	human
# DISEASE	GBRB3_HUMAN	Epilepsy, childhood absence 5 (ECA5) [MIM 612269]  A subtype of idiopathic generalized epilepsy characterized by an onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. Tonic-clonic seizures often develop in adolescence. Absence seizures may either remit or persist into adulthood. {ECO 0000269|PubMed 18514161}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# DrugBank	DB00186	Lorazepam
# DrugBank	DB00189	Ethchlorvynol
# DrugBank	DB00228	Enflurane
# DrugBank	DB00231	Temazepam
# DrugBank	DB00237	Butabarbital
# DrugBank	DB00241	Butalbital
# DrugBank	DB00273	Topiramate
# DrugBank	DB00292	Etomidate
# DrugBank	DB00306	Talbutal
# DrugBank	DB00312	Pentobarbital
# DrugBank	DB00334	Olanzapine
# DrugBank	DB00349	Clobazam
# DrugBank	DB00371	Meprobamate
# DrugBank	DB00402	Eszopiclone
# DrugBank	DB00404	Alprazolam
# DrugBank	DB00475	Chlordiazepoxide
# DrugBank	DB00543	Amoxapine
# DrugBank	DB00546	Adinazolam
# DrugBank	DB00592	Piperazine
# DrugBank	DB00602	Ivermectin
# DrugBank	DB00628	Clorazepate
# DrugBank	DB00659	Acamprosate
# DrugBank	DB00683	Midazolam
# DrugBank	DB00690	Flurazepam
# DrugBank	DB00753	Isoflurane
# DrugBank	DB00794	Primidone
# DrugBank	DB00801	Halazepam
# DrugBank	DB00818	Propofol
# DrugBank	DB00829	Diazepam
# DrugBank	DB00842	Oxazepam
# DrugBank	DB00897	Triazolam
# DrugBank	DB00898	Ethanol
# DrugBank	DB01028	Methoxyflurane
# DrugBank	DB01049	Ergoloid mesylate
# DrugBank	DB01068	Clonazepam
# DrugBank	DB01107	Methyprylon
# DrugBank	DB01159	Halothane
# DrugBank	DB01189	Desflurane
# DrugBank	DB01205	Flumazenil
# DrugBank	DB01215	Estazolam
# DrugBank	DB01236	Sevoflurane
# DrugBank	DB01437	Glutethimide
# DrugBank	DB01558	Bromazepam
# DrugBank	DB01559	Clotiazepam
# DrugBank	DB01567	Fludiazepam
# DrugBank	DB01588	Prazepam
# DrugBank	DB01589	Quazepam
# DrugBank	DB01594	Cinolazepam
# DrugBank	DB01595	Nitrazepam
# DrugBank	DB06716	Fospropofol
# Ensembl	ENST00000299267	ENSP00000299267; ENSG00000166206. [P28472-2]
# Ensembl	ENST00000311550	ENSP00000308725; ENSG00000166206. [P28472-1]
# Ensembl	ENST00000400188	ENSP00000383049; ENSG00000166206. [P28472-3]
# Ensembl	ENST00000545868	ENSP00000439169; ENSG00000166206. [P28472-4]
# Ensembl	ENST00000622697	ENSP00000481004; ENSG00000166206. [P28472-4]
# Ensembl	ENST00000628124	ENSP00000486819; ENSG00000166206. [P28472-4]
# Ensembl	ENST00000636466	ENSP00000489768; ENSG00000166206. [P28472-4]
# ExpressionAtlas	P28472	baseline and differential
# FUNCTION	GBRB3_HUMAN	Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel. {ECO 0000269|PubMed 18281286, ECO 0000269|PubMed 18514161, ECO 0000269|PubMed 22243422, ECO 0000269|PubMed 22303015, ECO 0000269|PubMed 24909990}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IMP:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:1902711	GABA-A receptor complex; IMP:UniProtKB.
# GO_function	GO:0004890	GABA-A receptor activity; IMP:UniProtKB.
# GO_function	GO:0022851	GABA-gated chloride ion channel activity; IMP:UniProtKB.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0007605	sensory perception of sound; IEA:Ensembl.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0043524	negative regulation of neuron apoptotic process; IEA:Ensembl.
# GO_process	GO:0060021	palate development; ISS:UniProtKB.
# GO_process	GO:0060080	inhibitory postsynaptic potential; IEA:Ensembl.
# GO_process	GO:0060119	inner ear receptor cell development; IEA:Ensembl.
# GO_process	GO:0060384	innervation; IEA:Ensembl.
# GO_process	GO:0071420	cellular response to histamine; IDA:UniProtKB.
# GO_process	GO:0090102	cochlea development; IEA:Ensembl.
# GO_process	GO:1902476	chloride transmembrane transport; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.70.170.10	-; 1.
# Genevisible	P28472	HS
# HGNC	HGNC:4083	GABRB3
# InterPro	IPR002289	GABAAb_rcpt
# InterPro	IPR006028	GABAA/Glycine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04726	Serotonergic synapse
# KEGG_Pathway	ko04727	GABAergic synapse
# KEGG_Pathway	ko05032	Morphine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# MIM	137192	gene+phenotype
# MIM	612269	phenotype
# Organism	GBRB3_HUMAN	Homo sapiens (Human)
# Orphanet	106	Autism
# Orphanet	64280	Childhood absence epilepsy
# PANTHER	PTHR18945	PTHR18945; 2
# PDB	4COF	X-ray; 2.97 A; A/B/C/D/E=26-332, A/B/C/D/E=447-473
# PIR	A55275	A55275
# PIR	B45468	B45468
# POLYMORPHISM	GABRB3 variants may be associated with insomnia, a condition of inability to initiate or maintain sleep [MIM	137192]. 
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00253	GABAARECEPTR
# PRINTS	PR01160	GABAARBETA
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 15
# Reactome	R-HSA-112314	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
# Reactome	R-HSA-975298	Ligand-gated ion channel transport
# Reactome	R-HSA-977441	GABA A receptor activation
# RecName	GBRB3_HUMAN	Gamma-aminobutyric acid receptor subunit beta-3
# RefSeq	NP_000805	NM_000814.5. [P28472-1]
# RefSeq	NP_001178249	NM_001191320.1. [P28472-4]
# RefSeq	NP_001178250	NM_001191321.2. [P28472-3]
# RefSeq	NP_001265560	NM_001278631.1. [P28472-4]
# RefSeq	NP_068712	NM_021912.4. [P28472-2]
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB3 sub-subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	GBRB3_HUMAN	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane {ECO 0000269|PubMed 18281286, ECO 0000269|PubMed 18514161, ECO 0000269|PubMed 22243422, ECO 0000269|PubMed 22303015, ECO 0000269|PubMed 24909990}; Multi-pass membrane protein {ECO 0000255}. Cytoplasmic vesicle membrane {ECO 0000250|UniProtKB P63079}. 
# SUBUNIT	GBRB3_HUMAN	Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains (PubMed 22243422, PubMed 18281286, PubMed 18514161, PubMed 24909990). Can form functional homopentamers (in vitro) (PubMed 22303015). Interacts with UBQLN1 (By similarity). May interact with KIF21B (By similarity). {ECO 0000250|UniProtKB P63079, ECO 0000269|PubMed 18281286, ECO 0000269|PubMed 18514161, ECO 0000269|PubMed 22243422, ECO 0000269|PubMed 22303015, ECO 0000269|PubMed 24909990}. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TCDB	1.A.9.5	the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family
# TIGRFAMs	TIGR00860	LIC
# UCSC	uc001zaz	human. [P28472-1]
# WEB RESOURCE	GBRB3_HUMAN	Name=Protein Spotlight; Note=Forbidden fruit - Issue 56 of March 2005; URL="http //web.expasy.org/spotlight/back_issues/056";
# eggNOG	ENOG410XPWH	LUCA
# eggNOG	KOG3643	Eukaryota
BLAST	swissprot:GBRB3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GBRB3_HUMAN
COXPRESdb	2562	http://coxpresdb.jp/data/gene/2562.shtml
CleanEx	HS_GABRB3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GABRB3
DIP	DIP-61029N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-61029N
DOI	10.1007/s00439-002-0766-7	http://dx.doi.org/10.1007/s00439-002-0766-7
DOI	10.1016/0888-7543(91)90034-C	http://dx.doi.org/10.1016/0888-7543(91)90034-C
DOI	10.1016/j.ajhg.2008.04.020	http://dx.doi.org/10.1016/j.ajhg.2008.04.020
DOI	10.1021/bi201772m	http://dx.doi.org/10.1021/bi201772m
DOI	10.1038/nature04601	http://dx.doi.org/10.1038/nature04601
DOI	10.1038/nature13293	http://dx.doi.org/10.1038/nature13293
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M111.332528	http://dx.doi.org/10.1074/jbc.M111.332528
DOI	10.1074/jbc.M709993200	http://dx.doi.org/10.1074/jbc.M709993200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00186	http://www.drugbank.ca/drugs/DB00186
DrugBank	DB00189	http://www.drugbank.ca/drugs/DB00189
DrugBank	DB00228	http://www.drugbank.ca/drugs/DB00228
DrugBank	DB00231	http://www.drugbank.ca/drugs/DB00231
DrugBank	DB00237	http://www.drugbank.ca/drugs/DB00237
DrugBank	DB00241	http://www.drugbank.ca/drugs/DB00241
DrugBank	DB00273	http://www.drugbank.ca/drugs/DB00273
DrugBank	DB00292	http://www.drugbank.ca/drugs/DB00292
DrugBank	DB00306	http://www.drugbank.ca/drugs/DB00306
DrugBank	DB00312	http://www.drugbank.ca/drugs/DB00312
DrugBank	DB00334	http://www.drugbank.ca/drugs/DB00334
DrugBank	DB00349	http://www.drugbank.ca/drugs/DB00349
DrugBank	DB00371	http://www.drugbank.ca/drugs/DB00371
DrugBank	DB00402	http://www.drugbank.ca/drugs/DB00402
DrugBank	DB00404	http://www.drugbank.ca/drugs/DB00404
DrugBank	DB00475	http://www.drugbank.ca/drugs/DB00475
DrugBank	DB00543	http://www.drugbank.ca/drugs/DB00543
DrugBank	DB00546	http://www.drugbank.ca/drugs/DB00546
DrugBank	DB00592	http://www.drugbank.ca/drugs/DB00592
DrugBank	DB00602	http://www.drugbank.ca/drugs/DB00602
DrugBank	DB00628	http://www.drugbank.ca/drugs/DB00628
DrugBank	DB00659	http://www.drugbank.ca/drugs/DB00659
DrugBank	DB00683	http://www.drugbank.ca/drugs/DB00683
DrugBank	DB00690	http://www.drugbank.ca/drugs/DB00690
DrugBank	DB00753	http://www.drugbank.ca/drugs/DB00753
DrugBank	DB00794	http://www.drugbank.ca/drugs/DB00794
DrugBank	DB00801	http://www.drugbank.ca/drugs/DB00801
DrugBank	DB00818	http://www.drugbank.ca/drugs/DB00818
DrugBank	DB00829	http://www.drugbank.ca/drugs/DB00829
DrugBank	DB00842	http://www.drugbank.ca/drugs/DB00842
DrugBank	DB00897	http://www.drugbank.ca/drugs/DB00897
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01028	http://www.drugbank.ca/drugs/DB01028
DrugBank	DB01049	http://www.drugbank.ca/drugs/DB01049
DrugBank	DB01068	http://www.drugbank.ca/drugs/DB01068
DrugBank	DB01107	http://www.drugbank.ca/drugs/DB01107
DrugBank	DB01159	http://www.drugbank.ca/drugs/DB01159
DrugBank	DB01189	http://www.drugbank.ca/drugs/DB01189
DrugBank	DB01205	http://www.drugbank.ca/drugs/DB01205
DrugBank	DB01215	http://www.drugbank.ca/drugs/DB01215
DrugBank	DB01236	http://www.drugbank.ca/drugs/DB01236
DrugBank	DB01437	http://www.drugbank.ca/drugs/DB01437
DrugBank	DB01558	http://www.drugbank.ca/drugs/DB01558
DrugBank	DB01559	http://www.drugbank.ca/drugs/DB01559
DrugBank	DB01567	http://www.drugbank.ca/drugs/DB01567
DrugBank	DB01588	http://www.drugbank.ca/drugs/DB01588
DrugBank	DB01589	http://www.drugbank.ca/drugs/DB01589
DrugBank	DB01594	http://www.drugbank.ca/drugs/DB01594
DrugBank	DB01595	http://www.drugbank.ca/drugs/DB01595
DrugBank	DB06716	http://www.drugbank.ca/drugs/DB06716
EMBL	AC009878	http://www.ebi.ac.uk/ena/data/view/AC009878
EMBL	AC011196	http://www.ebi.ac.uk/ena/data/view/AC011196
EMBL	AC104569	http://www.ebi.ac.uk/ena/data/view/AC104569
EMBL	AC127511	http://www.ebi.ac.uk/ena/data/view/AC127511
EMBL	AC135999	http://www.ebi.ac.uk/ena/data/view/AC135999
EMBL	AC145167	http://www.ebi.ac.uk/ena/data/view/AC145167
EMBL	AC145196	http://www.ebi.ac.uk/ena/data/view/AC145196
EMBL	AK295167	http://www.ebi.ac.uk/ena/data/view/AK295167
EMBL	AK302822	http://www.ebi.ac.uk/ena/data/view/AK302822
EMBL	BC010641	http://www.ebi.ac.uk/ena/data/view/BC010641
EMBL	CH471151	http://www.ebi.ac.uk/ena/data/view/CH471151
EMBL	EU606048	http://www.ebi.ac.uk/ena/data/view/EU606048
EMBL	L04311	http://www.ebi.ac.uk/ena/data/view/L04311
EMBL	L04311	http://www.ebi.ac.uk/ena/data/view/L04311
EMBL	M82919	http://www.ebi.ac.uk/ena/data/view/M82919
Ensembl	ENST00000299267	http://www.ensembl.org/id/ENST00000299267
Ensembl	ENST00000311550	http://www.ensembl.org/id/ENST00000311550
Ensembl	ENST00000400188	http://www.ensembl.org/id/ENST00000400188
Ensembl	ENST00000545868	http://www.ensembl.org/id/ENST00000545868
Ensembl	ENST00000622697	http://www.ensembl.org/id/ENST00000622697
Ensembl	ENST00000628124	http://www.ensembl.org/id/ENST00000628124
Ensembl	ENST00000636466	http://www.ensembl.org/id/ENST00000636466
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_component	GO:1902711	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902711
GO_function	GO:0004890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004890
GO_function	GO:0022851	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022851
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007605
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0043524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043524
GO_process	GO:0060021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060021
GO_process	GO:0060080	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060080
GO_process	GO:0060119	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060119
GO_process	GO:0060384	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060384
GO_process	GO:0071420	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071420
GO_process	GO:0090102	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090102
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	GABRB3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GABRB3
GeneID	2562	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2562
GeneTree	ENSGT00760000118821	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118821
HGNC	HGNC:4083	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4083
HOVERGEN	HBG051707	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051707&db=HOVERGEN
HPA	CAB002159	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB002159
InParanoid	P28472	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P28472
IntAct	P28472	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P28472*
InterPro	IPR002289	http://www.ebi.ac.uk/interpro/entry/IPR002289
InterPro	IPR006028	http://www.ebi.ac.uk/interpro/entry/IPR006028
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
Jabion	2562	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2562
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:2562	http://www.genome.jp/dbget-bin/www_bget?hsa:2562
KEGG_Orthology	KO:K05181	http://www.genome.jp/dbget-bin/www_bget?KO:K05181
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04726	http://www.genome.jp/kegg-bin/show_pathway?ko04726
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
KEGG_Pathway	ko05032	http://www.genome.jp/kegg-bin/show_pathway?ko05032
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
MIM	137192	http://www.ncbi.nlm.nih.gov/omim/137192
MIM	612269	http://www.ncbi.nlm.nih.gov/omim/612269
Orphanet	106	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=106
Orphanet	64280	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=64280
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PDB	4COF	http://www.ebi.ac.uk/pdbe-srv/view/entry/4COF
PDBsum	4COF	http://www.ebi.ac.uk/pdbsum/4COF
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00253	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00253
PRINTS	PR01160	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01160
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:GBRB3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GBRB3_HUMAN
PSORT-B	swissprot:GBRB3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GBRB3_HUMAN
PSORT2	swissprot:GBRB3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GBRB3_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA28497	http://www.pharmgkb.org/do/serve?objId=PA28497&objCls=Gene
Phobius	swissprot:GBRB3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GBRB3_HUMAN
PhylomeDB	P28472	http://phylomedb.org/?seqid=P28472
ProteinModelPortal	P28472	http://www.proteinmodelportal.org/query/uniprot/P28472
PubMed	12189488	http://www.ncbi.nlm.nih.gov/pubmed/12189488
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16572171	http://www.ncbi.nlm.nih.gov/pubmed/16572171
PubMed	1664410	http://www.ncbi.nlm.nih.gov/pubmed/1664410
PubMed	1714232	http://www.ncbi.nlm.nih.gov/pubmed/1714232
PubMed	18281286	http://www.ncbi.nlm.nih.gov/pubmed/18281286
PubMed	18514161	http://www.ncbi.nlm.nih.gov/pubmed/18514161
PubMed	22243422	http://www.ncbi.nlm.nih.gov/pubmed/22243422
PubMed	22303015	http://www.ncbi.nlm.nih.gov/pubmed/22303015
PubMed	24909990	http://www.ncbi.nlm.nih.gov/pubmed/24909990
PubMed	8382702	http://www.ncbi.nlm.nih.gov/pubmed/8382702
Reactome	R-HSA-112314	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112314
Reactome	R-HSA-975298	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-975298
Reactome	R-HSA-977441	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-977441
RefSeq	NP_000805	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000805
RefSeq	NP_001178249	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001178249
RefSeq	NP_001178250	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001178250
RefSeq	NP_001265560	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001265560
RefSeq	NP_068712	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_068712
SMR	P28472	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P28472
STRING	9606.ENSP00000299267	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000299267&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TCDB	1.A.9.5	http://www.tcdb.org/search/result.php?tc=1.A.9.5
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc001zaz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001zaz&org=rat
UniGene	Hs.302352	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.302352
UniGene	Hs.727263	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.727263
UniProtKB	GBRB3_HUMAN	http://www.uniprot.org/uniprot/GBRB3_HUMAN
UniProtKB-AC	P28472	http://www.uniprot.org/uniprot/P28472
charge	swissprot:GBRB3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GBRB3_HUMAN
eggNOG	ENOG410XPWH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPWH
eggNOG	KOG3643	http://eggnogapi.embl.de/nog_data/html/tree/KOG3643
epestfind	swissprot:GBRB3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GBRB3_HUMAN
garnier	swissprot:GBRB3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GBRB3_HUMAN
helixturnhelix	swissprot:GBRB3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GBRB3_HUMAN
hmoment	swissprot:GBRB3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GBRB3_HUMAN
iep	swissprot:GBRB3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GBRB3_HUMAN
inforesidue	swissprot:GBRB3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GBRB3_HUMAN
neXtProt	NX_P28472	http://www.nextprot.org/db/entry/NX_P28472
octanol	swissprot:GBRB3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GBRB3_HUMAN
pepcoil	swissprot:GBRB3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GBRB3_HUMAN
pepdigest	swissprot:GBRB3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GBRB3_HUMAN
pepinfo	swissprot:GBRB3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GBRB3_HUMAN
pepnet	swissprot:GBRB3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GBRB3_HUMAN
pepstats	swissprot:GBRB3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GBRB3_HUMAN
pepwheel	swissprot:GBRB3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GBRB3_HUMAN
pepwindow	swissprot:GBRB3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GBRB3_HUMAN
sigcleave	swissprot:GBRB3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GBRB3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	VATG2_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O95670-1; Sequence=Displayed; Name=2; IsoId=O95670-2; Sequence=VSP_045909; Note=No experimental confirmation available.; Name=3; IsoId=O95670-3; Sequence=VSP_047411; Note=No experimental confirmation available.; 
# AltName	VATG2_HUMAN	V-ATPase 13 kDa subunit 2
# AltName	VATG2_HUMAN	Vacuolar proton pump subunit G 2
# BioGrid	107017	5
# CCDS	CCDS4698	-. [O95670-1]
# CCDS	CCDS4699	-. [O95670-3]
# CCDS	CCDS56413	-. [O95670-2]
# Ensembl	ENST00000303892	ENSP00000302194; ENSG00000213760. [O95670-1]
# Ensembl	ENST00000376151	ENSP00000365321; ENSG00000213760. [O95670-2]
# Ensembl	ENST00000383503	ENSP00000372995; ENSG00000206445. [O95670-1]
# Ensembl	ENST00000421596	ENSP00000406575; ENSG00000234668. [O95670-2]
# Ensembl	ENST00000434217	ENSP00000406668; ENSG00000226850. [O95670-2]
# Ensembl	ENST00000441959	ENSP00000395436; ENSG00000227587. [O95670-1]
# Ensembl	ENST00000443657	ENSP00000416031; ENSG00000227587. [O95670-2]
# Ensembl	ENST00000444088	ENSP00000406389; ENSG00000234920. [O95670-1]
# Ensembl	ENST00000447174	ENSP00000403158; ENSG00000230900. [O95670-2]
# Ensembl	ENST00000448779	ENSP00000409104; ENSG00000234920. [O95670-2]
# Ensembl	ENST00000449748	ENSP00000406372; ENSG00000226850. [O95670-1]
# Ensembl	ENST00000452453	ENSP00000402430; ENSG00000206445. [O95670-2]
# Ensembl	ENST00000454370	ENSP00000413222; ENSG00000234668. [O95670-1]
# Ensembl	ENST00000454889	ENSP00000408670; ENSG00000230900. [O95670-1]
# Ensembl	ENST00000483251	ENSP00000419698; ENSG00000213760. [O95670-3]
# ExpressionAtlas	O95670	baseline and differential
# FUNCTION	VATG2_HUMAN	Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. 
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0016471	vacuolar proton-transporting V-type ATPase complex; IEA:InterPro.
# GO_component	GO:0042470	melanosome; IEA:UniProtKB-SubCell.
# GO_function	GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances; IEA:InterPro.
# GO_process	GO:0008286	insulin receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0016241	regulation of macroautophagy; NAS:ParkinsonsUK-UCL.
# GO_process	GO:0033572	transferrin transport; TAS:Reactome.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0090383	phagosome acidification; TAS:Reactome.
# GO_process	GO:1902600	hydrogen ion transmembrane transport; IEA:GOC.
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	O95670	HS
# HGNC	HGNC:862	ATP6V1G2
# IntAct	O95670	3
# InterPro	IPR005124	V-ATPase_G
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04966	Collecting duct acid secretion
# KEGG_Pathway	ko05110	Vibrio cholerae infection
# KEGG_Pathway	ko05120	Epithelial cell signaling in Helicobacter pylori infection
# KEGG_Pathway	ko05323	Rheumatoid arthritis
# MIM	606853	gene
# Organism	VATG2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12713	PTHR12713
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-1222556	ROS, RNS production in response to bacteria
# Reactome	R-HSA-77387	Insulin receptor recycling
# Reactome	R-HSA-917977	Transferrin endocytosis and recycling
# Reactome	R-HSA-983712	Ion channel transport
# RecName	VATG2_HUMAN	V-type proton ATPase subunit G 2
# RefSeq	NP_001191007	NM_001204078.1. [O95670-2]
# RefSeq	NP_569730	NM_130463.3. [O95670-1]
# RefSeq	NP_612139	NM_138282.2. [O95670-3]
# SIMILARITY	Belongs to the V-ATPase G subunit family. {ECO	0000305}.
# SUBCELLULAR LOCATION	VATG2_HUMAN	Melanosome {ECO 0000269|PubMed 17081065}. Note=Highly enriched in late-stage melanosomes. 
# SUBUNIT	V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d). {ECO	0000250}. 
# TIGRFAMs	TIGR01147	V_ATP_synt_G
# TISSUE SPECIFICITY	Brain. {ECO:0000269|PubMed	12384298}. 
# UCSC	uc003ntz	human. [O95670-1]
# eggNOG	ENOG4111XX0	LUCA
# eggNOG	KOG1772	Eukaryota
BLAST	swissprot:VATG2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VATG2_HUMAN
BioCyc	MetaCyc:HS10685-MONOMER	http://biocyc.org/getid?id=MetaCyc:HS10685-MONOMER
BioCyc	ZFISH:HS10685-MONOMER	http://biocyc.org/getid?id=ZFISH:HS10685-MONOMER
COXPRESdb	534	http://coxpresdb.jp/data/gene/534.shtml
CleanEx	HS_ATP6V1G2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP6V1G2
DOI	10.1016/S0378-1119(02)00884-3	http://dx.doi.org/10.1016/S0378-1119(02)00884-3
DOI	10.1021/pr060363j	http://dx.doi.org/10.1021/pr060363j
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1534/genetics.106.057034	http://dx.doi.org/10.1534/genetics.106.057034
EMBL	AA401769	http://www.ebi.ac.uk/ena/data/view/AA401769
EMBL	AB063177	http://www.ebi.ac.uk/ena/data/view/AB063177
EMBL	AB088115	http://www.ebi.ac.uk/ena/data/view/AB088115
EMBL	AB097672	http://www.ebi.ac.uk/ena/data/view/AB097672
EMBL	AB102692	http://www.ebi.ac.uk/ena/data/view/AB102692
EMBL	AB103621	http://www.ebi.ac.uk/ena/data/view/AB103621
EMBL	AB202112	http://www.ebi.ac.uk/ena/data/view/AB202112
EMBL	AL662801	http://www.ebi.ac.uk/ena/data/view/AL662801
EMBL	AL662847	http://www.ebi.ac.uk/ena/data/view/AL662847
EMBL	BA000025	http://www.ebi.ac.uk/ena/data/view/BA000025
EMBL	BC047791	http://www.ebi.ac.uk/ena/data/view/BC047791
EMBL	BC119726	http://www.ebi.ac.uk/ena/data/view/BC119726
EMBL	BC119727	http://www.ebi.ac.uk/ena/data/view/BC119727
EMBL	BX001040	http://www.ebi.ac.uk/ena/data/view/BX001040
EMBL	BX001040	http://www.ebi.ac.uk/ena/data/view/BX001040
EMBL	BX248516	http://www.ebi.ac.uk/ena/data/view/BX248516
EMBL	BX248516	http://www.ebi.ac.uk/ena/data/view/BX248516
EMBL	BX927320	http://www.ebi.ac.uk/ena/data/view/BX927320
EMBL	BX927320	http://www.ebi.ac.uk/ena/data/view/BX927320
EMBL	CH471081	http://www.ebi.ac.uk/ena/data/view/CH471081
EMBL	CH471081	http://www.ebi.ac.uk/ena/data/view/CH471081
EMBL	CR753820	http://www.ebi.ac.uk/ena/data/view/CR753820
EMBL	CR753864	http://www.ebi.ac.uk/ena/data/view/CR753864
EMBL	CR753864	http://www.ebi.ac.uk/ena/data/view/CR753864
EMBL	CR753892	http://www.ebi.ac.uk/ena/data/view/CR753892
EMBL	CR753892	http://www.ebi.ac.uk/ena/data/view/CR753892
EMBL	CR942185	http://www.ebi.ac.uk/ena/data/view/CR942185
EMBL	Y14768	http://www.ebi.ac.uk/ena/data/view/Y14768
Ensembl	ENST00000303892	http://www.ensembl.org/id/ENST00000303892
Ensembl	ENST00000376151	http://www.ensembl.org/id/ENST00000376151
Ensembl	ENST00000383503	http://www.ensembl.org/id/ENST00000383503
Ensembl	ENST00000421596	http://www.ensembl.org/id/ENST00000421596
Ensembl	ENST00000434217	http://www.ensembl.org/id/ENST00000434217
Ensembl	ENST00000441959	http://www.ensembl.org/id/ENST00000441959
Ensembl	ENST00000443657	http://www.ensembl.org/id/ENST00000443657
Ensembl	ENST00000444088	http://www.ensembl.org/id/ENST00000444088
Ensembl	ENST00000447174	http://www.ensembl.org/id/ENST00000447174
Ensembl	ENST00000448779	http://www.ensembl.org/id/ENST00000448779
Ensembl	ENST00000449748	http://www.ensembl.org/id/ENST00000449748
Ensembl	ENST00000452453	http://www.ensembl.org/id/ENST00000452453
Ensembl	ENST00000454370	http://www.ensembl.org/id/ENST00000454370
Ensembl	ENST00000454889	http://www.ensembl.org/id/ENST00000454889
Ensembl	ENST00000483251	http://www.ensembl.org/id/ENST00000483251
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0016471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016471
GO_component	GO:0042470	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042470
GO_function	GO:0016820	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016820
GO_process	GO:0008286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008286
GO_process	GO:0016241	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016241
GO_process	GO:0033572	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033572
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0090383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090383
GO_process	GO:1902600	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902600
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ATP6V1G2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP6V1G2
GeneID	534	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=534
GeneTree	ENSGT00390000011172	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000011172
HGNC	HGNC:862	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:862
HOGENOM	HOG000186416	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000186416&db=HOGENOM6
HOVERGEN	HBG057827	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG057827&db=HOVERGEN
HPA	CAB004616	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB004616
InParanoid	O95670	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O95670
IntAct	O95670	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O95670*
InterPro	IPR005124	http://www.ebi.ac.uk/interpro/entry/IPR005124
Jabion	534	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=534
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:534	http://www.genome.jp/dbget-bin/www_bget?hsa:534
KEGG_Orthology	KO:K02152	http://www.genome.jp/dbget-bin/www_bget?KO:K02152
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04966	http://www.genome.jp/kegg-bin/show_pathway?ko04966
KEGG_Pathway	ko05110	http://www.genome.jp/kegg-bin/show_pathway?ko05110
KEGG_Pathway	ko05120	http://www.genome.jp/kegg-bin/show_pathway?ko05120
KEGG_Pathway	ko05323	http://www.genome.jp/kegg-bin/show_pathway?ko05323
MIM	606853	http://www.ncbi.nlm.nih.gov/omim/606853
MINT	MINT-1035852	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1035852
OMA	HPNYRIT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HPNYRIT
OrthoDB	EOG091G0XIZ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0XIZ
PANTHER	PTHR12713	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12713
PSORT	swissprot:VATG2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VATG2_HUMAN
PSORT-B	swissprot:VATG2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VATG2_HUMAN
PSORT2	swissprot:VATG2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VATG2_HUMAN
PharmGKB	PA25164	http://www.pharmgkb.org/do/serve?objId=PA25164&objCls=Gene
Phobius	swissprot:VATG2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VATG2_HUMAN
PhylomeDB	O95670	http://phylomedb.org/?seqid=O95670
ProteinModelPortal	O95670	http://www.proteinmodelportal.org/query/uniprot/O95670
PubMed	10202016	http://www.ncbi.nlm.nih.gov/pubmed/10202016
PubMed	12384298	http://www.ncbi.nlm.nih.gov/pubmed/12384298
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16702430	http://www.ncbi.nlm.nih.gov/pubmed/16702430
PubMed	17081065	http://www.ncbi.nlm.nih.gov/pubmed/17081065
Reactome	R-HSA-1222556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1222556
Reactome	R-HSA-77387	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-77387
Reactome	R-HSA-917977	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917977
Reactome	R-HSA-983712	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983712
RefSeq	NP_001191007	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001191007
RefSeq	NP_569730	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_569730
RefSeq	NP_612139	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_612139
SMR	O95670	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O95670
STRING	9606.ENSP00000302194	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000302194&targetmode=cogs
TIGRFAMs	TIGR01147	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01147
UCSC	uc003ntz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ntz&org=rat
UniGene	Hs.249227	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.249227
UniProtKB	VATG2_HUMAN	http://www.uniprot.org/uniprot/VATG2_HUMAN
UniProtKB-AC	O95670	http://www.uniprot.org/uniprot/O95670
charge	swissprot:VATG2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VATG2_HUMAN
eggNOG	ENOG4111XX0	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111XX0
eggNOG	KOG1772	http://eggnogapi.embl.de/nog_data/html/tree/KOG1772
epestfind	swissprot:VATG2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VATG2_HUMAN
garnier	swissprot:VATG2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VATG2_HUMAN
helixturnhelix	swissprot:VATG2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VATG2_HUMAN
hmoment	swissprot:VATG2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VATG2_HUMAN
iep	swissprot:VATG2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VATG2_HUMAN
inforesidue	swissprot:VATG2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VATG2_HUMAN
neXtProt	NX_O95670	http://www.nextprot.org/db/entry/NX_O95670
octanol	swissprot:VATG2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VATG2_HUMAN
pepcoil	swissprot:VATG2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VATG2_HUMAN
pepdigest	swissprot:VATG2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VATG2_HUMAN
pepinfo	swissprot:VATG2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VATG2_HUMAN
pepnet	swissprot:VATG2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VATG2_HUMAN
pepstats	swissprot:VATG2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VATG2_HUMAN
pepwheel	swissprot:VATG2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VATG2_HUMAN
pepwindow	swissprot:VATG2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VATG2_HUMAN
sigcleave	swissprot:VATG2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VATG2_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNK3_HUMAN	Acid-sensitive potassium channel protein TASK-1
# AltName	KCNK3_HUMAN	TWIK-related acid-sensitive K(+) channel 1
# AltName	KCNK3_HUMAN	Two pore potassium channel KT3.1
# BioGrid	109978	3
# DISEASE	KCNK3_HUMAN	Pulmonary hypertension, primary, 4 (PPH4) [MIM 615344]  A rare disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial pulmonary hypertension is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs. {ECO 0000269|PubMed 23883380}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00561	Doxapram
# DrugBank	DB01159	Halothane
# Ensembl	ENST00000302909	ENSP00000306275; ENSG00000171303
# ExpressionAtlas	O14649	baseline and differential
# FUNCTION	KCNK3_HUMAN	pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. {ECO 0000269|PubMed 23169818, ECO 0000269|PubMed 9312005}. 
# GO_component	GO:0005886	plasma membrane; IMP:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_function	GO:0005216	ion channel activity; IMP:UniProtKB.
# GO_function	GO:0005252	open rectifier potassium channel activity; IEA:Ensembl.
# GO_function	GO:0005267	potassium channel activity; TAS:Reactome.
# GO_function	GO:0022841	potassium ion leak channel activity; IDA:UniProtKB.
# GO_function	GO:0044548	S100 protein binding; IPI:UniProtKB.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:ProtInc.
# GO_process	GO:0007420	brain development; IEA:Ensembl.
# GO_process	GO:0030322	stabilization of membrane potential; IBA:GO_Central.
# GO_process	GO:0034220	ion transmembrane transport; IMP:UniProtKB.
# GO_process	GO:0042493	response to drug; IEA:Ensembl.
# GO_process	GO:0051481	negative regulation of cytosolic calcium ion concentration; IEA:Ensembl.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:0071294	cellular response to zinc ion; IEA:Ensembl.
# GO_process	GO:0071456	cellular response to hypoxia; IEA:Ensembl.
# GO_process	GO:0090102	cochlea development; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	O14649	HS
# HGNC	HGNC:6278	KCNK3
# InterPro	IPR003092	2pore_dom_K_chnl_TASK
# InterPro	IPR003280	2pore_dom_K_chnl
# InterPro	IPR005406	KCNK3
# InterPro	IPR013099	K_chnl_dom
# KEGG_Brite	ko04040	Ion channels
# KEGG_Disease	H01621	[Cardiovascular disease] Pulmonary arterial hypertension (PAH)
# MIM	603220	gene
# MIM	615344	phenotype
# MISCELLANEOUS	KCNK3_HUMAN	Inhibited by external acidification. Activated by halothane and isoflurane. 
# Organism	KCNK3_HUMAN	Homo sapiens (Human)
# Orphanet	275766	Idiopathic pulmonary arterial hypertension
# Orphanet	275777	Heritable pulmonary arterial hypertension
# PIRSF	PIRSF038061	K_channel_subfamily_K_type
# PRINTS	PR01095	TASKCHANNEL
# PRINTS	PR01333	2POREKCHANEL
# PRINTS	PR01584	TASK1CHANNEL
# Pfam	PF07885	Ion_trans_2; 2
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-1299316	TWIK-releated acid-sensitive K+ channel (TASK)
# Reactome	R-HSA-5576886	Phase 4 - resting membrane potential
# RecName	KCNK3_HUMAN	Potassium channel subfamily K member 3
# RefSeq	NP_002237	NM_002246.2
# SIMILARITY	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCNK3_HUMAN	Cell membrane {ECO 0000269|PubMed 23169818}; Multi-pass membrane protein {ECO 0000305}. 
# SUBUNIT	Homodimer (Probable). Heterodimer with KCNK1. {ECO:0000269|PubMed	23169818, ECO:0000305}. 
# TCDB	1.A.1.9	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	KCNK3_HUMAN	Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon. 
# UCSC	uc002rhn	human
# eggNOG	ENOG410XRZJ	LUCA
# eggNOG	KOG4404	Eukaryota
BLAST	swissprot:KCNK3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNK3_HUMAN
BioCyc	ZFISH:ENSG00000171303-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000171303-MONOMER
COXPRESdb	3777	http://coxpresdb.jp/data/gene/3777.shtml
CleanEx	HS_KCNK3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNK3
DOI	10.1007/s004240100620	http://dx.doi.org/10.1007/s004240100620
DOI	10.1038/8084	http://dx.doi.org/10.1038/8084
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1056/NEJMoa1211097	http://dx.doi.org/10.1056/NEJMoa1211097
DOI	10.1074/jbc.M001948200	http://dx.doi.org/10.1074/jbc.M001948200
DOI	10.1093/emboj/16.17.5464	http://dx.doi.org/10.1093/emboj/16.17.5464
DOI	10.1126/scisignal.2003431	http://dx.doi.org/10.1126/scisignal.2003431
DrugBank	DB00561	http://www.drugbank.ca/drugs/DB00561
DrugBank	DB01159	http://www.drugbank.ca/drugs/DB01159
EMBL	AC015977	http://www.ebi.ac.uk/ena/data/view/AC015977
EMBL	AF006823	http://www.ebi.ac.uk/ena/data/view/AF006823
EMBL	AF065163	http://www.ebi.ac.uk/ena/data/view/AF065163
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
Ensembl	ENST00000302909	http://www.ensembl.org/id/ENST00000302909
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005216	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005216
GO_function	GO:0005252	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005252
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_function	GO:0022841	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022841
GO_function	GO:0044548	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044548
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007420	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007420
GO_process	GO:0030322	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030322
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0051481	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051481
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:0071294	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071294
GO_process	GO:0071456	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071456
GO_process	GO:0090102	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090102
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	KCNK3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNK3
GeneID	3777	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3777
GeneTree	ENSGT00760000118858	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118858
HGNC	HGNC:6278	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6278
HOGENOM	HOG000231463	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231463&db=HOGENOM6
HOVERGEN	HBG052239	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052239&db=HOVERGEN
HPA	HPA026658	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA026658
InParanoid	O14649	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O14649
InterPro	IPR003092	http://www.ebi.ac.uk/interpro/entry/IPR003092
InterPro	IPR003280	http://www.ebi.ac.uk/interpro/entry/IPR003280
InterPro	IPR005406	http://www.ebi.ac.uk/interpro/entry/IPR005406
InterPro	IPR013099	http://www.ebi.ac.uk/interpro/entry/IPR013099
Jabion	3777	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3777
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H01621	http://www.genome.jp/dbget-bin/www_bget?H01621
KEGG_Gene	hsa:3777	http://www.genome.jp/dbget-bin/www_bget?hsa:3777
KEGG_Orthology	KO:K04914	http://www.genome.jp/dbget-bin/www_bget?KO:K04914
MIM	603220	http://www.ncbi.nlm.nih.gov/omim/603220
MIM	615344	http://www.ncbi.nlm.nih.gov/omim/615344
MINT	MINT-1645466	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1645466
OMA	FRSLMKR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FRSLMKR
Orphanet	275766	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=275766
Orphanet	275777	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=275777
OrthoDB	EOG091G08DH	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08DH
PRINTS	PR01095	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01095
PRINTS	PR01333	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01333
PRINTS	PR01584	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01584
PSORT	swissprot:KCNK3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNK3_HUMAN
PSORT-B	swissprot:KCNK3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNK3_HUMAN
PSORT2	swissprot:KCNK3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNK3_HUMAN
Pfam	PF07885	http://pfam.xfam.org/family/PF07885
PharmGKB	PA30060	http://www.pharmgkb.org/do/serve?objId=PA30060&objCls=Gene
Phobius	swissprot:KCNK3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNK3_HUMAN
PhylomeDB	O14649	http://phylomedb.org/?seqid=O14649
ProteinModelPortal	O14649	http://www.proteinmodelportal.org/query/uniprot/O14649
PubMed	10321245	http://www.ncbi.nlm.nih.gov/pubmed/10321245
PubMed	10748056	http://www.ncbi.nlm.nih.gov/pubmed/10748056
PubMed	11680614	http://www.ncbi.nlm.nih.gov/pubmed/11680614
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	23169818	http://www.ncbi.nlm.nih.gov/pubmed/23169818
PubMed	23883380	http://www.ncbi.nlm.nih.gov/pubmed/23883380
PubMed	9312005	http://www.ncbi.nlm.nih.gov/pubmed/9312005
Reactome	R-HSA-1299316	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1299316
Reactome	R-HSA-5576886	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576886
RefSeq	NP_002237	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002237
STRING	9606.ENSP00000306275	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000306275&targetmode=cogs
TCDB	1.A.1.9	http://www.tcdb.org/search/result.php?tc=1.A.1.9
UCSC	uc002rhn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002rhn&org=rat
UniGene	Hs.24040	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.24040
UniGene	Hs.645288	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.645288
UniProtKB	KCNK3_HUMAN	http://www.uniprot.org/uniprot/KCNK3_HUMAN
UniProtKB-AC	O14649	http://www.uniprot.org/uniprot/O14649
charge	swissprot:KCNK3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNK3_HUMAN
eggNOG	ENOG410XRZJ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRZJ
eggNOG	KOG4404	http://eggnogapi.embl.de/nog_data/html/tree/KOG4404
epestfind	swissprot:KCNK3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNK3_HUMAN
garnier	swissprot:KCNK3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNK3_HUMAN
helixturnhelix	swissprot:KCNK3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNK3_HUMAN
hmoment	swissprot:KCNK3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNK3_HUMAN
iep	swissprot:KCNK3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNK3_HUMAN
inforesidue	swissprot:KCNK3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNK3_HUMAN
neXtProt	NX_O14649	http://www.nextprot.org/db/entry/NX_O14649
octanol	swissprot:KCNK3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNK3_HUMAN
pepcoil	swissprot:KCNK3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNK3_HUMAN
pepdigest	swissprot:KCNK3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNK3_HUMAN
pepinfo	swissprot:KCNK3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNK3_HUMAN
pepnet	swissprot:KCNK3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNK3_HUMAN
pepstats	swissprot:KCNK3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNK3_HUMAN
pepwheel	swissprot:KCNK3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNK3_HUMAN
pepwindow	swissprot:KCNK3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNK3_HUMAN
sigcleave	swissprot:KCNK3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNK3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CTL1_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=A; IsoId=Q8WWI5-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q8WWI5-2; Sequence=VSP_015424, VSP_015425; Name=3; Synonyms=C; IsoId=Q8WWI5-3; Sequence=VSP_015426, VSP_015427; 
# AltName	CTL1_HUMAN	CD92
# AltName	CTL1_HUMAN	CDw92
# AltName	CTL1_HUMAN	Solute carrier family 44 member 1
# BioGrid	117012	11
# CCDS	CCDS6763	-. [Q8WWI5-1]
# CCDS	CCDS75868	-. [Q8WWI5-3]
# CCDS	CCDS83390	-. [Q8WWI5-2]
# ChiTaRS	SLC44A1	human
# DrugBank	DB00122	Choline
# Ensembl	ENST00000374720	ENSP00000363852; ENSG00000070214. [Q8WWI5-1]
# Ensembl	ENST00000374723	ENSP00000363855; ENSG00000070214. [Q8WWI5-3]
# Ensembl	ENST00000374724	ENSP00000363856; ENSG00000070214. [Q8WWI5-2]
# Ensembl	ENST00000470972	ENSP00000433072; ENSG00000070214. [Q8WWI5-1]
# ExpressionAtlas	Q8WWI5	baseline and differential
# FUNCTION	CTL1_HUMAN	Choline transporter. May be involved in membrane synthesis and myelin production. {ECO 0000269|PubMed 19357133}. 
# GO_component	GO:0005654	nucleoplasm; IDA:HPA.
# GO_component	GO:0005739	mitochondrion; IDA:HPA.
# GO_component	GO:0005741	mitochondrial outer membrane; TAS:Reactome.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; TAS:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0015220	choline transmembrane transporter activity; TAS:UniProtKB.
# GO_process	GO:0006656	phosphatidylcholine biosynthetic process; TAS:Reactome.
# GO_process	GO:0015871	choline transport; TAS:UniProtKB.
# GO_process	GO:0042426	choline catabolic process; TAS:Reactome.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0009056	catabolic process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q8WWI5	HS
# HGNC	HGNC:18798	SLC44A1
# IntAct	Q8WWI5	4
# InterPro	IPR007603	Choline_transptr-like
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Brite	ko04090	 Cellular antigens
# MIM	606105	gene
# Organism	CTL1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12385	PTHR12385
# Pfam	PF04515	Choline_transpo
# Proteomes	UP000005640	Chromosome 9
# Reactome	R-HSA-1483191	Synthesis of PC
# Reactome	R-HSA-425366	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
# Reactome	R-HSA-6798163	Choline catabolism
# RecName	CTL1_HUMAN	Choline transporter-like protein 1
# RefSeq	NP_001273659	NM_001286730.1. [Q8WWI5-3]
# RefSeq	NP_001317660	NM_001330731.1
# RefSeq	NP_536856	NM_080546.4. [Q8WWI5-1]
# SIMILARITY	Belongs to the CTL (choline transporter-like) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	CTL1_HUMAN	Cell membrane {ECO 0000269|PubMed 19357133}; Multi-pass membrane protein {ECO 0000269|PubMed 19357133}. Mitochondrion outer membrane {ECO 0000269|PubMed 19357133}; Multi- pass membrane protein {ECO 0000269|PubMed 19357133}. 
# TCDB	2.A.92.1	the choline transporter-like (ctl) family
# TISSUE SPECIFICITY	Expressed in various cells of the hematopoietic system. {ECO:0000269|PubMed	11698453}. 
# UCSC	uc004bcn	human. [Q8WWI5-1]
# eggNOG	ENOG410XS0P	LUCA
# eggNOG	KOG1362	Eukaryota
BLAST	swissprot:CTL1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CTL1_HUMAN
COXPRESdb	23446	http://coxpresdb.jp/data/gene/23446.shtml
CleanEx	HS_SLC44A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC44A1
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
DOI	10.1073/pnas.030339697	http://dx.doi.org/10.1073/pnas.030339697
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/mcp.M111.015131	http://dx.doi.org/10.1074/mcp.M111.015131
DOI	10.1096/fj.08-121491	http://dx.doi.org/10.1096/fj.08-121491
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1471-4159.2004.02962.x	http://dx.doi.org/10.1111/j.1471-4159.2004.02962.x
DOI	10.4049/jimmunol.167.10.5795	http://dx.doi.org/10.4049/jimmunol.167.10.5795
DrugBank	DB00122	http://www.drugbank.ca/drugs/DB00122
EMBL	AJ245620	http://www.ebi.ac.uk/ena/data/view/AJ245620
EMBL	AJ272365	http://www.ebi.ac.uk/ena/data/view/AJ272365
EMBL	AJ420812	http://www.ebi.ac.uk/ena/data/view/AJ420812
EMBL	AL161627	http://www.ebi.ac.uk/ena/data/view/AL161627
EMBL	AL161627	http://www.ebi.ac.uk/ena/data/view/AL161627
EMBL	AL161627	http://www.ebi.ac.uk/ena/data/view/AL161627
EMBL	AL161627	http://www.ebi.ac.uk/ena/data/view/AL161627
EMBL	AL161627	http://www.ebi.ac.uk/ena/data/view/AL161627
EMBL	AL161627	http://www.ebi.ac.uk/ena/data/view/AL161627
EMBL	AL161627	http://www.ebi.ac.uk/ena/data/view/AL161627
EMBL	AL161627	http://www.ebi.ac.uk/ena/data/view/AL161627
EMBL	AL161627	http://www.ebi.ac.uk/ena/data/view/AL161627
EMBL	AL450265	http://www.ebi.ac.uk/ena/data/view/AL450265
EMBL	AL450265	http://www.ebi.ac.uk/ena/data/view/AL450265
EMBL	AL450265	http://www.ebi.ac.uk/ena/data/view/AL450265
EMBL	AL450265	http://www.ebi.ac.uk/ena/data/view/AL450265
EMBL	AL450265	http://www.ebi.ac.uk/ena/data/view/AL450265
EMBL	AL450265	http://www.ebi.ac.uk/ena/data/view/AL450265
EMBL	AL450265	http://www.ebi.ac.uk/ena/data/view/AL450265
EMBL	AL450265	http://www.ebi.ac.uk/ena/data/view/AL450265
EMBL	AL450265	http://www.ebi.ac.uk/ena/data/view/AL450265
EMBL	AL590368	http://www.ebi.ac.uk/ena/data/view/AL590368
EMBL	AL590368	http://www.ebi.ac.uk/ena/data/view/AL590368
EMBL	AL590368	http://www.ebi.ac.uk/ena/data/view/AL590368
EMBL	AL590368	http://www.ebi.ac.uk/ena/data/view/AL590368
EMBL	AL590368	http://www.ebi.ac.uk/ena/data/view/AL590368
EMBL	AL590368	http://www.ebi.ac.uk/ena/data/view/AL590368
EMBL	AL590368	http://www.ebi.ac.uk/ena/data/view/AL590368
EMBL	AL590368	http://www.ebi.ac.uk/ena/data/view/AL590368
EMBL	AL590368	http://www.ebi.ac.uk/ena/data/view/AL590368
EMBL	BC018213	http://www.ebi.ac.uk/ena/data/view/BC018213
EMBL	BC049203	http://www.ebi.ac.uk/ena/data/view/BC049203
Ensembl	ENST00000374720	http://www.ensembl.org/id/ENST00000374720
Ensembl	ENST00000374723	http://www.ensembl.org/id/ENST00000374723
Ensembl	ENST00000374724	http://www.ensembl.org/id/ENST00000374724
Ensembl	ENST00000470972	http://www.ensembl.org/id/ENST00000470972
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005741	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005741
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0015220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015220
GO_process	GO:0006656	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006656
GO_process	GO:0015871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015871
GO_process	GO:0042426	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042426
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0009056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC44A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC44A1
GeneID	23446	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23446
GeneTree	ENSGT00550000074521	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074521
HGNC	HGNC:18798	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18798
HOGENOM	HOG000231655	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231655&db=HOGENOM6
HOVERGEN	HBG080361	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG080361&db=HOVERGEN
HPA	HPA064714	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA064714
InParanoid	Q8WWI5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8WWI5
IntAct	Q8WWI5	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8WWI5*
InterPro	IPR007603	http://www.ebi.ac.uk/interpro/entry/IPR007603
Jabion	23446	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=23446
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Brite	ko04090	http://www.genome.jp/dbget-bin/www_bget?ko04090
KEGG_Gene	hsa:23446	http://www.genome.jp/dbget-bin/www_bget?hsa:23446
KEGG_Orthology	KO:K06515	http://www.genome.jp/dbget-bin/www_bget?KO:K06515
MIM	606105	http://www.ncbi.nlm.nih.gov/omim/606105
MINT	MINT-8247377	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8247377
OMA	ICGFTIV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ICGFTIV
OrthoDB	EOG091G0CMQ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0CMQ
PANTHER	PTHR12385	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12385
PSORT	swissprot:CTL1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CTL1_HUMAN
PSORT-B	swissprot:CTL1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CTL1_HUMAN
PSORT2	swissprot:CTL1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CTL1_HUMAN
Pfam	PF04515	http://pfam.xfam.org/family/PF04515
PharmGKB	PA134958011	http://www.pharmgkb.org/do/serve?objId=PA134958011&objCls=Gene
Phobius	swissprot:CTL1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CTL1_HUMAN
PhylomeDB	Q8WWI5	http://phylomedb.org/?seqid=Q8WWI5
ProteinModelPortal	Q8WWI5	http://www.proteinmodelportal.org/query/uniprot/Q8WWI5
PubMed	10677542	http://www.ncbi.nlm.nih.gov/pubmed/10677542
PubMed	11698453	http://www.ncbi.nlm.nih.gov/pubmed/11698453
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15715662	http://www.ncbi.nlm.nih.gov/pubmed/15715662
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19357133	http://www.ncbi.nlm.nih.gov/pubmed/19357133
PubMed	22223895	http://www.ncbi.nlm.nih.gov/pubmed/22223895
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-1483191	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1483191
Reactome	R-HSA-425366	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425366
Reactome	R-HSA-6798163	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6798163
RefSeq	NP_001273659	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273659
RefSeq	NP_001317660	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001317660
RefSeq	NP_536856	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_536856
STRING	9606.ENSP00000363852	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000363852&targetmode=cogs
TCDB	2.A.92.1	http://www.tcdb.org/search/result.php?tc=2.A.92.1
UCSC	uc004bcn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004bcn&org=rat
UniGene	Hs.573495	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.573495
UniProtKB	CTL1_HUMAN	http://www.uniprot.org/uniprot/CTL1_HUMAN
UniProtKB-AC	Q8WWI5	http://www.uniprot.org/uniprot/Q8WWI5
charge	swissprot:CTL1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CTL1_HUMAN
eggNOG	ENOG410XS0P	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS0P
eggNOG	KOG1362	http://eggnogapi.embl.de/nog_data/html/tree/KOG1362
epestfind	swissprot:CTL1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CTL1_HUMAN
garnier	swissprot:CTL1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CTL1_HUMAN
helixturnhelix	swissprot:CTL1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CTL1_HUMAN
hmoment	swissprot:CTL1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CTL1_HUMAN
iep	swissprot:CTL1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CTL1_HUMAN
inforesidue	swissprot:CTL1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CTL1_HUMAN
neXtProt	NX_Q8WWI5	http://www.nextprot.org/db/entry/NX_Q8WWI5
octanol	swissprot:CTL1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CTL1_HUMAN
pepcoil	swissprot:CTL1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CTL1_HUMAN
pepdigest	swissprot:CTL1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CTL1_HUMAN
pepinfo	swissprot:CTL1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CTL1_HUMAN
pepnet	swissprot:CTL1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CTL1_HUMAN
pepstats	swissprot:CTL1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CTL1_HUMAN
pepwheel	swissprot:CTL1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CTL1_HUMAN
pepwindow	swissprot:CTL1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CTL1_HUMAN
sigcleave	swissprot:CTL1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CTL1_HUMAN
## Database	ID	URL or Descriptions
# AltName	CXD2_HUMAN	Connexin-36
# AltName	CXD2_HUMAN	Gap junction alpha-9 protein
# Ensembl	ENST00000290374	ENSP00000290374; ENSG00000159248
# FUNCTION	CXD2_HUMAN	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005922	connexin complex; IEA:InterPro.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005243	gap junction channel activity; TAS:Reactome.
# GO_process	GO:0001508	action potential; IEA:Ensembl.
# GO_process	GO:0007268	chemical synaptic transmission; IEA:Ensembl.
# GO_process	GO:0007601	visual perception; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# Genevisible	Q9UKL4	HS
# HGNC	HGNC:19154	GJD2
# InterPro	IPR000500	Connexin
# InterPro	IPR002260	Connexin36
# InterPro	IPR013092	Connexin_N
# InterPro	IPR017990	Connexin_CS
# InterPro	IPR019570	Connexin_CCC
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Pathway	ko04540	Gap junction
# MIM	607058	gene
# Organism	CXD2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11984	PTHR11984; 2
# PDB	2N6A	NMR; -; A=276-292
# PRINTS	PR00206	CONNEXIN
# PRINTS	PR01131	CONNEXIN36
# PROSITE	PS00407	CONNEXINS_1
# PROSITE	PS00408	CONNEXINS_2
# Pfam	PF00029	Connexin
# Proteomes	UP000005640	Chromosome 15
# Reactome	R-HSA-112303	Electric Transmission Across Gap Junctions
# Reactome	R-HSA-190861	Gap junction assembly
# RecName	CXD2_HUMAN	Gap junction delta-2 protein
# RefSeq	NP_065711	NM_020660.2
# SIMILARITY	Belongs to the connexin family. Delta-type subfamily. {ECO	0000305}.
# SMART	SM00037	CNX
# SMART	SM01089	Connexin_CCC
# SUBCELLULAR LOCATION	CXD2_HUMAN	Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. 
# SUBUNIT	CXD2_HUMAN	A connexon is composed of a hexamer of connexins. 
# TISSUE SPECIFICITY	CXD2_HUMAN	Highly expressed in neurons. 
# UCSC	uc001zis	human
# eggNOG	ENOG410IJ31	Eukaryota
# eggNOG	ENOG410YRD5	LUCA
BLAST	swissprot:CXD2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CXD2_HUMAN
COXPRESdb	57369	http://coxpresdb.jp/data/gene/57369.shtml
CleanEx	HS_GJA9	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GJA9
CleanEx	HS_GJD2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GJD2
DOI	10.1002/(SICI)1097-4547(19990901)57:5<740::AID-JNR16>3.0.CO	http://dx.doi.org/10.1002/(SICI)1097-4547(19990901)57:5<740::AID-JNR16>3.0.CO
DOI	10.1093/molbev/msh100	http://dx.doi.org/10.1093/molbev/msh100
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB037509	http://www.ebi.ac.uk/ena/data/view/AB037509
EMBL	AF153047	http://www.ebi.ac.uk/ena/data/view/AF153047
EMBL	BC069339	http://www.ebi.ac.uk/ena/data/view/BC069339
EMBL	BC112110	http://www.ebi.ac.uk/ena/data/view/BC112110
EMBL	BC112114	http://www.ebi.ac.uk/ena/data/view/BC112114
Ensembl	ENST00000290374	http://www.ensembl.org/id/ENST00000290374
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005922	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005922
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005243	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005243
GO_process	GO:0001508	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001508
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007601	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007601
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	GJD2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GJD2
GeneID	57369	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57369
GeneTree	ENSGT00840000129674	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00840000129674
HGNC	HGNC:19154	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:19154
HOGENOM	HOG000231127	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231127&db=HOGENOM6
HOVERGEN	HBG009576	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG009576&db=HOVERGEN
HPA	HPA014355	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014355
InParanoid	Q9UKL4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UKL4
InterPro	IPR000500	http://www.ebi.ac.uk/interpro/entry/IPR000500
InterPro	IPR002260	http://www.ebi.ac.uk/interpro/entry/IPR002260
InterPro	IPR013092	http://www.ebi.ac.uk/interpro/entry/IPR013092
InterPro	IPR017990	http://www.ebi.ac.uk/interpro/entry/IPR017990
InterPro	IPR019570	http://www.ebi.ac.uk/interpro/entry/IPR019570
Jabion	57369	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=57369
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Gene	hsa:57369	http://www.genome.jp/dbget-bin/www_bget?hsa:57369
KEGG_Orthology	KO:K07373	http://www.genome.jp/dbget-bin/www_bget?KO:K07373
KEGG_Pathway	ko04540	http://www.genome.jp/kegg-bin/show_pathway?ko04540
MIM	607058	http://www.ncbi.nlm.nih.gov/omim/607058
OMA	NKETEPD	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NKETEPD
OrthoDB	EOG091G0FB1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0FB1
PANTHER	PTHR11984	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11984
PDB	2N6A	http://www.ebi.ac.uk/pdbe-srv/view/entry/2N6A
PDBsum	2N6A	http://www.ebi.ac.uk/pdbsum/2N6A
PRINTS	PR00206	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00206
PRINTS	PR01131	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01131
PROSITE	PS00407	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00407
PROSITE	PS00408	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00408
PSORT	swissprot:CXD2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CXD2_HUMAN
PSORT-B	swissprot:CXD2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CXD2_HUMAN
PSORT2	swissprot:CXD2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CXD2_HUMAN
Pfam	PF00029	http://pfam.xfam.org/family/PF00029
PharmGKB	PA162389706	http://www.pharmgkb.org/do/serve?objId=PA162389706&objCls=Gene
Phobius	swissprot:CXD2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CXD2_HUMAN
PhylomeDB	Q9UKL4	http://phylomedb.org/?seqid=Q9UKL4
ProteinModelPortal	Q9UKL4	http://www.proteinmodelportal.org/query/uniprot/Q9UKL4
PubMed	10462698	http://www.ncbi.nlm.nih.gov/pubmed/10462698
PubMed	15014171	http://www.ncbi.nlm.nih.gov/pubmed/15014171
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-112303	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112303
Reactome	R-HSA-190861	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-190861
RefSeq	NP_065711	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_065711
SMART	SM00037	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00037
SMART	SM01089	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01089
SMR	Q9UKL4	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9UKL4
STRING	9606.ENSP00000290374	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000290374&targetmode=cogs
UCSC	uc001zis	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001zis&org=rat
UniGene	Hs.283816	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.283816
UniProtKB	CXD2_HUMAN	http://www.uniprot.org/uniprot/CXD2_HUMAN
UniProtKB-AC	Q9UKL4	http://www.uniprot.org/uniprot/Q9UKL4
charge	swissprot:CXD2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CXD2_HUMAN
eggNOG	ENOG410IJ31	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IJ31
eggNOG	ENOG410YRD5	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YRD5
epestfind	swissprot:CXD2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CXD2_HUMAN
garnier	swissprot:CXD2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CXD2_HUMAN
helixturnhelix	swissprot:CXD2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CXD2_HUMAN
hmoment	swissprot:CXD2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CXD2_HUMAN
iep	swissprot:CXD2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CXD2_HUMAN
inforesidue	swissprot:CXD2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CXD2_HUMAN
neXtProt	NX_Q9UKL4	http://www.nextprot.org/db/entry/NX_Q9UKL4
octanol	swissprot:CXD2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CXD2_HUMAN
pepcoil	swissprot:CXD2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CXD2_HUMAN
pepdigest	swissprot:CXD2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CXD2_HUMAN
pepinfo	swissprot:CXD2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CXD2_HUMAN
pepnet	swissprot:CXD2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CXD2_HUMAN
pepstats	swissprot:CXD2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CXD2_HUMAN
pepwheel	swissprot:CXD2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CXD2_HUMAN
pepwindow	swissprot:CXD2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CXD2_HUMAN
sigcleave	swissprot:CXD2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CXD2_HUMAN
## Database	ID	URL or Descriptions
# AltName	S45A3_HUMAN	Prostate cancer-associated protein 6
# AltName	S45A3_HUMAN	Prostein
# ChiTaRS	SLC45A3	human
# Ensembl	ENST00000367145	ENSP00000356113; ENSG00000158715
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	S45A3_HUMAN	GO 0008506 sucrose proton symporter activity; ISS ParkinsonsUK-UCL.
# GO_process	GO:0010907	positive regulation of glucose metabolic process; ISS:ParkinsonsUK-UCL.
# GO_process	GO:0015770	sucrose transport; ISS:ParkinsonsUK-UCL.
# GO_process	GO:0045723	positive regulation of fatty acid biosynthetic process; ISS:ParkinsonsUK-UCL.
# GO_process	GO:0048713	regulation of oligodendrocyte differentiation; ISS:ParkinsonsUK-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q96JT2	HS
# HGNC	HGNC:8642	SLC45A3
# INDUCTION	Up-regulated by androgens. {ECO:0000269|PubMed	11245466}. 
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H00024	[Cancer] Prostate cancer
# KEGG_Pathway	ko05202	Transcriptional misregulation in cancer
# MIM	605097	gene
# MISCELLANEOUS	S45A3_HUMAN	Marker for prostate cells. May be used, in case of prostate cancers, as a target antigen for prostate carcinomas- directed cytotoxic T-cell lymphocytes. 
# Organism	S45A3_HUMAN	Homo sapiens (Human)
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-70153	Glucose transport
# RecName	S45A3_HUMAN	Solute carrier family 45 member 3
# RefSeq	NP_149093	NM_033102.2
# RefSeq	XP_005245613	XM_005245556.3
# RefSeq	XP_005245614	XM_005245557.4
# RefSeq	XP_016858127	XM_017002638.1
# SIMILARITY	Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S45A3_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.2.4:the glycoside-pentoside-hexuronide (gph)	cation symporter family
# TISSUE SPECIFICITY	S45A3_HUMAN	Prostate specific. Expressed in all prostatic glandular cells. Expressed both in normal and cancerous prostates. {ECO 0000269|PubMed 11245466, ECO 0000269|PubMed 14997204}. 
# UCSC	uc001hda	human
# eggNOG	ENOG410XPTR	LUCA
# eggNOG	KOG0637	Eukaryota
BLAST	swissprot:S45A3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S45A3_HUMAN
BioCyc	ZFISH:ENSG00000158715-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000158715-MONOMER
COXPRESdb	85414	http://coxpresdb.jp/data/gene/85414.shtml
CleanEx	HS_SLC45A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC45A3
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.bjc.6601642	http://dx.doi.org/10.1038/sj.bjc.6601642
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AK290364	http://www.ebi.ac.uk/ena/data/view/AK290364
EMBL	AK313479	http://www.ebi.ac.uk/ena/data/view/AK313479
EMBL	AY033593	http://www.ebi.ac.uk/ena/data/view/AY033593
EMBL	BC050416	http://www.ebi.ac.uk/ena/data/view/BC050416
EMBL	CH471067	http://www.ebi.ac.uk/ena/data/view/CH471067
Ensembl	ENST00000367145	http://www.ensembl.org/id/ENST00000367145
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0008506	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008506
GO_process	GO:0010907	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010907
GO_process	GO:0015770	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015770
GO_process	GO:0045723	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045723
GO_process	GO:0048713	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048713
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	SLC45A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC45A3
GeneID	85414	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=85414
GeneTree	ENSGT00390000018882	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000018882
HGNC	HGNC:8642	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:8642
HOGENOM	HOG000013046	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000013046&db=HOGENOM6
HOVERGEN	HBG053519	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053519&db=HOVERGEN
HPA	HPA019073	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA019073
HPA	HPA019075	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA019075
InParanoid	Q96JT2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96JT2
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	85414	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=85414
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00024	http://www.genome.jp/dbget-bin/www_bget?H00024
KEGG_Gene	hsa:85414	http://www.genome.jp/dbget-bin/www_bget?hsa:85414
KEGG_Orthology	KO:K15379	http://www.genome.jp/dbget-bin/www_bget?KO:K15379
KEGG_Pathway	ko05202	http://www.genome.jp/kegg-bin/show_pathway?ko05202
MIM	605097	http://www.ncbi.nlm.nih.gov/omim/605097
OMA	LCGASAC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LCGASAC
OrthoDB	EOG091G0DTJ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0DTJ
PSORT	swissprot:S45A3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S45A3_HUMAN
PSORT-B	swissprot:S45A3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S45A3_HUMAN
PSORT2	swissprot:S45A3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S45A3_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA32981	http://www.pharmgkb.org/do/serve?objId=PA32981&objCls=Gene
Phobius	swissprot:S45A3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S45A3_HUMAN
PhylomeDB	Q96JT2	http://phylomedb.org/?seqid=Q96JT2
ProteinModelPortal	Q96JT2	http://www.proteinmodelportal.org/query/uniprot/Q96JT2
PubMed	11245466	http://www.ncbi.nlm.nih.gov/pubmed/11245466
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	14997204	http://www.ncbi.nlm.nih.gov/pubmed/14997204
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-70153	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-70153
RefSeq	NP_149093	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_149093
RefSeq	XP_005245613	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005245613
RefSeq	XP_005245614	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005245614
RefSeq	XP_016858127	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016858127
STRING	9606.ENSP00000356113	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000356113&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.2.4	http://www.tcdb.org/search/result.php?tc=2.A.2.4
UCSC	uc001hda	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001hda&org=rat
UniGene	Hs.278695	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.278695
UniProtKB	S45A3_HUMAN	http://www.uniprot.org/uniprot/S45A3_HUMAN
UniProtKB-AC	Q96JT2	http://www.uniprot.org/uniprot/Q96JT2
charge	swissprot:S45A3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S45A3_HUMAN
eggNOG	ENOG410XPTR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPTR
eggNOG	KOG0637	http://eggnogapi.embl.de/nog_data/html/tree/KOG0637
epestfind	swissprot:S45A3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S45A3_HUMAN
garnier	swissprot:S45A3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S45A3_HUMAN
helixturnhelix	swissprot:S45A3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S45A3_HUMAN
hmoment	swissprot:S45A3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S45A3_HUMAN
iep	swissprot:S45A3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S45A3_HUMAN
inforesidue	swissprot:S45A3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S45A3_HUMAN
neXtProt	NX_Q96JT2	http://www.nextprot.org/db/entry/NX_Q96JT2
octanol	swissprot:S45A3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S45A3_HUMAN
pepcoil	swissprot:S45A3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S45A3_HUMAN
pepdigest	swissprot:S45A3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S45A3_HUMAN
pepinfo	swissprot:S45A3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S45A3_HUMAN
pepnet	swissprot:S45A3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S45A3_HUMAN
pepstats	swissprot:S45A3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S45A3_HUMAN
pepwheel	swissprot:S45A3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S45A3_HUMAN
pepwindow	swissprot:S45A3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S45A3_HUMAN
sigcleave	swissprot:S45A3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S45A3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	MOT6_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O15375-1; Sequence=Displayed; Name=2; IsoId=O15375-2; Sequence=VSP_056660, VSP_056661; Note=No experimental confirmation available.; 
# AltName	MOT6_HUMAN	Monocarboxylate transporter 5
# AltName	MOT6_HUMAN	Solute carrier family 16 member 5
# CCDS	CCDS11713	-. [O15375-1]
# CDD	cd06174	MFS
# DrugBank	DB00119	Pyruvic acid
# Ensembl	ENST00000329783	ENSP00000330141; ENSG00000170190. [O15375-1]
# Ensembl	ENST00000450736	ENSP00000390564; ENSG00000170190. [O15375-1]
# Ensembl	ENST00000538213	ENSP00000440212; ENSG00000170190. [O15375-2]
# Ensembl	ENST00000580123	ENSP00000463434; ENSG00000170190. [O15375-1]
# ExpressionAtlas	O15375	baseline and differential
# FUNCTION	MOT6_HUMAN	Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). {ECO 0000250}. 
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_function	GO:0008028	monocarboxylic acid transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0015129	lactate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_process	GO:0015718	monocarboxylic acid transport; TAS:ProtInc.
# GO_process	GO:0035879	plasma membrane lactate transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	O15375	HS
# HGNC	HGNC:10926	SLC16A5
# InterPro	IPR004743	MCT
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# InterPro	IPR030760	MCT6
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	603879	gene
# Organism	MOT6_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11360:SF21	PTHR11360:SF21
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 17
# RecName	MOT6_HUMAN	Monocarboxylate transporter 6
# RefSeq	NP_001258694	NM_001271765.1. [O15375-1]
# RefSeq	NP_004686	NM_004695.3. [O15375-1]
# SIMILARITY	Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	MOT6_HUMAN	Cell membrane; Multi-pass membrane protein. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.13.11	the major facilitator superfamily (mfs)
# TIGRFAMs	TIGR00892	2A0113
# TISSUE SPECIFICITY	MOT6_HUMAN	Highly expressed in kidney. 
# UCSC	uc002jmr	human. [O15375-1]
# eggNOG	COG0477	LUCA
# eggNOG	KOG2504	Eukaryota
BLAST	swissprot:MOT6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MOT6_HUMAN
BioCyc	ZFISH:ENSG00000170190-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000170190-MONOMER
COXPRESdb	9121	http://coxpresdb.jp/data/gene/9121.shtml
CleanEx	HS_SLC16A5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC16A5
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/bj3290321	http://dx.doi.org/10.1042/bj3290321
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00119	http://www.drugbank.ca/drugs/DB00119
EMBL	AC111186	http://www.ebi.ac.uk/ena/data/view/AC111186
EMBL	AK304163	http://www.ebi.ac.uk/ena/data/view/AK304163
EMBL	BC009684	http://www.ebi.ac.uk/ena/data/view/BC009684
EMBL	BC033611	http://www.ebi.ac.uk/ena/data/view/BC033611
EMBL	U59299	http://www.ebi.ac.uk/ena/data/view/U59299
Ensembl	ENST00000329783	http://www.ensembl.org/id/ENST00000329783
Ensembl	ENST00000450736	http://www.ensembl.org/id/ENST00000450736
Ensembl	ENST00000538213	http://www.ensembl.org/id/ENST00000538213
Ensembl	ENST00000580123	http://www.ensembl.org/id/ENST00000580123
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0008028	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008028
GO_function	GO:0015129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015129
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_process	GO:0015718	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015718
GO_process	GO:0035879	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035879
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC16A5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC16A5
GeneID	9121	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9121
GeneTree	ENSGT00760000118926	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118926
HGNC	HGNC:10926	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10926
HOGENOM	HOG000280688	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280688&db=HOGENOM6
HOVERGEN	HBG006384	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006384&db=HOVERGEN
HPA	HPA046944	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA046944
InParanoid	O15375	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O15375
InterPro	IPR004743	http://www.ebi.ac.uk/interpro/entry/IPR004743
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
InterPro	IPR030760	http://www.ebi.ac.uk/interpro/entry/IPR030760
Jabion	9121	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9121
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:9121	http://www.genome.jp/dbget-bin/www_bget?hsa:9121
KEGG_Orthology	KO:K08182	http://www.genome.jp/dbget-bin/www_bget?KO:K08182
MIM	603879	http://www.ncbi.nlm.nih.gov/omim/603879
OMA	AYSVSMS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AYSVSMS
OrthoDB	EOG091G05SW	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05SW
PANTHER	PTHR11360:SF21	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11360:SF21
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:MOT6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MOT6_HUMAN
PSORT-B	swissprot:MOT6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MOT6_HUMAN
PSORT2	swissprot:MOT6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MOT6_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA35817	http://www.pharmgkb.org/do/serve?objId=PA35817&objCls=Gene
Phobius	swissprot:MOT6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MOT6_HUMAN
PhylomeDB	O15375	http://phylomedb.org/?seqid=O15375
ProteinModelPortal	O15375	http://www.proteinmodelportal.org/query/uniprot/O15375
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	9425115	http://www.ncbi.nlm.nih.gov/pubmed/9425115
RefSeq	NP_001258694	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001258694
RefSeq	NP_004686	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004686
STRING	9606.ENSP00000330141	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000330141&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.13.11	http://www.tcdb.org/search/result.php?tc=2.A.1.13.11
TIGRFAMs	TIGR00892	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00892
UCSC	uc002jmr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002jmr&org=rat
UniGene	Hs.592095	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.592095
UniProtKB	MOT6_HUMAN	http://www.uniprot.org/uniprot/MOT6_HUMAN
UniProtKB-AC	O15375	http://www.uniprot.org/uniprot/O15375
charge	swissprot:MOT6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MOT6_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG2504	http://eggnogapi.embl.de/nog_data/html/tree/KOG2504
epestfind	swissprot:MOT6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MOT6_HUMAN
garnier	swissprot:MOT6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MOT6_HUMAN
helixturnhelix	swissprot:MOT6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MOT6_HUMAN
hmoment	swissprot:MOT6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MOT6_HUMAN
iep	swissprot:MOT6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MOT6_HUMAN
inforesidue	swissprot:MOT6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MOT6_HUMAN
neXtProt	NX_O15375	http://www.nextprot.org/db/entry/NX_O15375
octanol	swissprot:MOT6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MOT6_HUMAN
pepcoil	swissprot:MOT6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MOT6_HUMAN
pepdigest	swissprot:MOT6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MOT6_HUMAN
pepinfo	swissprot:MOT6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MOT6_HUMAN
pepnet	swissprot:MOT6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MOT6_HUMAN
pepstats	swissprot:MOT6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MOT6_HUMAN
pepwheel	swissprot:MOT6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MOT6_HUMAN
pepwindow	swissprot:MOT6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MOT6_HUMAN
sigcleave	swissprot:MOT6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MOT6_HUMAN
## Database	ID	URL or Descriptions
# AltName	GTR7_HUMAN	Glucose transporter type 7
# CDD	cd06174	MFS
# Ensembl	ENST00000400906	ENSP00000383698; ENSG00000197241
# FUNCTION	GTR7_HUMAN	High-affinity transporter for glucose and fructose Does not transport galactose, 2-deoxy-d-glucose and xylose. {ECO 0000269|PubMed 15033637}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0051119	sugar transmembrane transporter activity; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# HGNC	HGNC:13445	SLC2A7
# InterPro	IPR003663	Sugar/inositol_transpt
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR005829	Sugar_transporter_CS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	610371	gene
# Organism	GTR7_HUMAN	Homo sapiens (Human)
# PDB	1YG7	Model; -; A=1-512
# PRINTS	PR00171	SUGRTRNSPORT
# PROSITE	PS00216	SUGAR_TRANSPORT_1
# PROSITE	PS00217	SUGAR_TRANSPORT_2
# PROSITE	PS50850	MFS
# Pfam	PF00083	Sugar_tr
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-428776	Class II GLUTs
# RecName	GTR7_HUMAN	Solute carrier family 2, facilitated glucose transporter member 7
# RefSeq	NP_997303	NM_207420.2
# SIMILARITY	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	GTR7_HUMAN	Membrane; Multi-pass membrane protein. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.1.37	the major facilitator superfamily (mfs)
# TIGRFAMs	TIGR00879	SP
# TISSUE SPECIFICITY	Expressed in small intestine and colon. Weakly expressed in testis and prostate. {ECO:0000269|PubMed	15033637}. 
# UCSC	uc009vmo	human
# eggNOG	COG0477	LUCA
# eggNOG	KOG0569	Eukaryota
BLAST	swissprot:GTR7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GTR7_HUMAN
BioCyc	ZFISH:G66-31784-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31784-MONOMER
COXPRESdb	155184	http://coxpresdb.jp/data/gene/155184.shtml
CleanEx	HS_SLC2A7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC2A7
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1152/ajpgi.00396.2003	http://dx.doi.org/10.1152/ajpgi.00396.2003
EMBL	AL158048	http://www.ebi.ac.uk/ena/data/view/AL158048
EMBL	AY571960	http://www.ebi.ac.uk/ena/data/view/AY571960
EMBL	CH471130	http://www.ebi.ac.uk/ena/data/view/CH471130
Ensembl	ENST00000400906	http://www.ensembl.org/id/ENST00000400906
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0051119	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051119
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GeneCards	SLC2A7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC2A7
GeneID	155184	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=155184
GeneTree	ENSGT00760000119022	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119022
HGNC	HGNC:13445	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13445
HOGENOM	HOG000202871	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202871&db=HOGENOM6
HOVERGEN	HBG014816	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG014816&db=HOVERGEN
HPA	HPA039931	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA039931
InParanoid	Q6PXP3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6PXP3
InterPro	IPR003663	http://www.ebi.ac.uk/interpro/entry/IPR003663
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR005829	http://www.ebi.ac.uk/interpro/entry/IPR005829
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	155184	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=155184
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:155184	http://www.genome.jp/dbget-bin/www_bget?hsa:155184
KEGG_Orthology	KO:K12201	http://www.genome.jp/dbget-bin/www_bget?KO:K12201
MIM	610371	http://www.ncbi.nlm.nih.gov/omim/610371
OMA	HSHIHED	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HSHIHED
OrthoDB	EOG091G0A9K	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0A9K
PDB	1YG7	http://www.ebi.ac.uk/pdbe-srv/view/entry/1YG7
PDBsum	1YG7	http://www.ebi.ac.uk/pdbsum/1YG7
PRINTS	PR00171	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00171
PROSITE	PS00216	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00216
PROSITE	PS00217	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00217
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:GTR7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GTR7_HUMAN
PSORT-B	swissprot:GTR7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GTR7_HUMAN
PSORT2	swissprot:GTR7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GTR7_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
PharmGKB	PA37770	http://www.pharmgkb.org/do/serve?objId=PA37770&objCls=Gene
Phobius	swissprot:GTR7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GTR7_HUMAN
PhylomeDB	Q6PXP3	http://phylomedb.org/?seqid=Q6PXP3
ProteinModelPortal	Q6PXP3	http://www.proteinmodelportal.org/query/uniprot/Q6PXP3
PubMed	15033637	http://www.ncbi.nlm.nih.gov/pubmed/15033637
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
Reactome	R-HSA-428776	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428776
RefSeq	NP_997303	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_997303
STRING	9606.ENSP00000383698	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000383698&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.1.37	http://www.tcdb.org/search/result.php?tc=2.A.1.1.37
TIGRFAMs	TIGR00879	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00879
UCSC	uc009vmo	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc009vmo&org=rat
UniGene	Hs.531239	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.531239
UniProtKB	GTR7_HUMAN	http://www.uniprot.org/uniprot/GTR7_HUMAN
UniProtKB-AC	Q6PXP3	http://www.uniprot.org/uniprot/Q6PXP3
charge	swissprot:GTR7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GTR7_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG0569	http://eggnogapi.embl.de/nog_data/html/tree/KOG0569
epestfind	swissprot:GTR7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GTR7_HUMAN
garnier	swissprot:GTR7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GTR7_HUMAN
helixturnhelix	swissprot:GTR7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GTR7_HUMAN
hmoment	swissprot:GTR7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GTR7_HUMAN
iep	swissprot:GTR7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GTR7_HUMAN
inforesidue	swissprot:GTR7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GTR7_HUMAN
neXtProt	NX_Q6PXP3	http://www.nextprot.org/db/entry/NX_Q6PXP3
octanol	swissprot:GTR7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GTR7_HUMAN
pepcoil	swissprot:GTR7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GTR7_HUMAN
pepdigest	swissprot:GTR7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GTR7_HUMAN
pepinfo	swissprot:GTR7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GTR7_HUMAN
pepnet	swissprot:GTR7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GTR7_HUMAN
pepstats	swissprot:GTR7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GTR7_HUMAN
pepwheel	swissprot:GTR7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GTR7_HUMAN
pepwindow	swissprot:GTR7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GTR7_HUMAN
sigcleave	swissprot:GTR7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GTR7_HUMAN
## Database	ID	URL or Descriptions
# AltName	GBRA6_HUMAN	GABA(A) receptor subunit alpha-6
# BioGrid	108833	12
# DrugBank	DB00186	Lorazepam
# DrugBank	DB00189	Ethchlorvynol
# DrugBank	DB00228	Enflurane
# DrugBank	DB00231	Temazepam
# DrugBank	DB00237	Butabarbital
# DrugBank	DB00241	Butalbital
# DrugBank	DB00273	Topiramate
# DrugBank	DB00292	Etomidate
# DrugBank	DB00306	Talbutal
# DrugBank	DB00312	Pentobarbital
# DrugBank	DB00334	Olanzapine
# DrugBank	DB00349	Clobazam
# DrugBank	DB00371	Meprobamate
# DrugBank	DB00402	Eszopiclone
# DrugBank	DB00404	Alprazolam
# DrugBank	DB00418	Secobarbital
# DrugBank	DB00475	Chlordiazepoxide
# DrugBank	DB00543	Amoxapine
# DrugBank	DB00599	Thiopental
# DrugBank	DB00628	Clorazepate
# DrugBank	DB00659	Acamprosate
# DrugBank	DB00683	Midazolam
# DrugBank	DB00690	Flurazepam
# DrugBank	DB00753	Isoflurane
# DrugBank	DB00794	Primidone
# DrugBank	DB00801	Halazepam
# DrugBank	DB00818	Propofol
# DrugBank	DB00829	Diazepam
# DrugBank	DB00842	Oxazepam
# DrugBank	DB00849	Methylphenobarbital
# DrugBank	DB00897	Triazolam
# DrugBank	DB00898	Ethanol
# DrugBank	DB01028	Methoxyflurane
# DrugBank	DB01049	Ergoloid mesylate
# DrugBank	DB01068	Clonazepam
# DrugBank	DB01107	Methyprylon
# DrugBank	DB01159	Halothane
# DrugBank	DB01189	Desflurane
# DrugBank	DB01205	Flumazenil
# DrugBank	DB01215	Estazolam
# DrugBank	DB01236	Sevoflurane
# DrugBank	DB01351	Amobarbital
# DrugBank	DB01352	Aprobarbital
# DrugBank	DB01353	Butethal
# DrugBank	DB01354	Heptabarbital
# DrugBank	DB01355	Hexobarbital
# DrugBank	DB01437	Glutethimide
# DrugBank	DB01544	Flunitrazepam
# DrugBank	DB01558	Bromazepam
# DrugBank	DB01588	Prazepam
# DrugBank	DB01589	Quazepam
# DrugBank	DB01595	Nitrazepam
# Ensembl	ENST00000274545	ENSP00000274545; ENSG00000145863
# ExpressionAtlas	Q16445	baseline and differential
# FUNCTION	GBRA6_HUMAN	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:1902711	GABA-A receptor complex; IBA:GO_Central.
# GO_function	GO:0004890	GABA-A receptor activity; IEA:InterPro.
# GO_function	GO:0005230	extracellular ligand-gated ion channel activity; IEA:InterPro.
# GO_function	GO:0005254	chloride channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0008503	benzodiazepine receptor activity; TAS:ProtInc.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0007214	gamma-aminobutyric acid signaling pathway; IEA:InterPro.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.70.170.10	-; 1.
# Genevisible	Q16445	HS
# HGNC	HGNC:4080	GABRA6
# InterPro	IPR001390	GABAAa_rcpt
# InterPro	IPR005436	GABBAa6_rcpt
# InterPro	IPR006028	GABAA/Glycine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04727	GABAergic synapse
# KEGG_Pathway	ko05032	Morphine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# MIM	137143	gene
# Organism	GBRA6_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR18945	PTHR18945; 2
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00253	GABAARECEPTR
# PRINTS	PR01079	GABAARALPHA
# PRINTS	PR01619	GABAARALPHA6
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-112314	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
# Reactome	R-HSA-975298	Ligand-gated ion channel transport
# Reactome	R-HSA-977441	GABA A receptor activation
# RecName	GBRA6_HUMAN	Gamma-aminobutyric acid receptor subunit alpha-6
# RefSeq	NP_000802	NM_000811.2
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA6 sub-subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	GBRA6_HUMAN	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. {ECO	0000250}. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TIGRFAMs	TIGR00860	LIC
# UCSC	uc003lyu	human
# WEB RESOURCE	GBRA6_HUMAN	Name=Protein Spotlight; Note=Forbidden fruit - Issue 56 of March 2005; URL="http //web.expasy.org/spotlight/back_issues/056";
# eggNOG	ENOG410XNQG	LUCA
# eggNOG	KOG3642	Eukaryota
BLAST	swissprot:GBRA6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GBRA6_HUMAN
BioCyc	ZFISH:ENSG00000145863-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000145863-MONOMER
COXPRESdb	2559	http://coxpresdb.jp/data/gene/2559.shtml
CleanEx	HS_GABRA6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GABRA6
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DrugBank	DB00186	http://www.drugbank.ca/drugs/DB00186
DrugBank	DB00189	http://www.drugbank.ca/drugs/DB00189
DrugBank	DB00228	http://www.drugbank.ca/drugs/DB00228
DrugBank	DB00231	http://www.drugbank.ca/drugs/DB00231
DrugBank	DB00237	http://www.drugbank.ca/drugs/DB00237
DrugBank	DB00241	http://www.drugbank.ca/drugs/DB00241
DrugBank	DB00273	http://www.drugbank.ca/drugs/DB00273
DrugBank	DB00292	http://www.drugbank.ca/drugs/DB00292
DrugBank	DB00306	http://www.drugbank.ca/drugs/DB00306
DrugBank	DB00312	http://www.drugbank.ca/drugs/DB00312
DrugBank	DB00334	http://www.drugbank.ca/drugs/DB00334
DrugBank	DB00349	http://www.drugbank.ca/drugs/DB00349
DrugBank	DB00371	http://www.drugbank.ca/drugs/DB00371
DrugBank	DB00402	http://www.drugbank.ca/drugs/DB00402
DrugBank	DB00404	http://www.drugbank.ca/drugs/DB00404
DrugBank	DB00418	http://www.drugbank.ca/drugs/DB00418
DrugBank	DB00475	http://www.drugbank.ca/drugs/DB00475
DrugBank	DB00543	http://www.drugbank.ca/drugs/DB00543
DrugBank	DB00599	http://www.drugbank.ca/drugs/DB00599
DrugBank	DB00628	http://www.drugbank.ca/drugs/DB00628
DrugBank	DB00659	http://www.drugbank.ca/drugs/DB00659
DrugBank	DB00683	http://www.drugbank.ca/drugs/DB00683
DrugBank	DB00690	http://www.drugbank.ca/drugs/DB00690
DrugBank	DB00753	http://www.drugbank.ca/drugs/DB00753
DrugBank	DB00794	http://www.drugbank.ca/drugs/DB00794
DrugBank	DB00801	http://www.drugbank.ca/drugs/DB00801
DrugBank	DB00818	http://www.drugbank.ca/drugs/DB00818
DrugBank	DB00829	http://www.drugbank.ca/drugs/DB00829
DrugBank	DB00842	http://www.drugbank.ca/drugs/DB00842
DrugBank	DB00849	http://www.drugbank.ca/drugs/DB00849
DrugBank	DB00897	http://www.drugbank.ca/drugs/DB00897
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01028	http://www.drugbank.ca/drugs/DB01028
DrugBank	DB01049	http://www.drugbank.ca/drugs/DB01049
DrugBank	DB01068	http://www.drugbank.ca/drugs/DB01068
DrugBank	DB01107	http://www.drugbank.ca/drugs/DB01107
DrugBank	DB01159	http://www.drugbank.ca/drugs/DB01159
DrugBank	DB01189	http://www.drugbank.ca/drugs/DB01189
DrugBank	DB01205	http://www.drugbank.ca/drugs/DB01205
DrugBank	DB01215	http://www.drugbank.ca/drugs/DB01215
DrugBank	DB01236	http://www.drugbank.ca/drugs/DB01236
DrugBank	DB01351	http://www.drugbank.ca/drugs/DB01351
DrugBank	DB01352	http://www.drugbank.ca/drugs/DB01352
DrugBank	DB01353	http://www.drugbank.ca/drugs/DB01353
DrugBank	DB01354	http://www.drugbank.ca/drugs/DB01354
DrugBank	DB01355	http://www.drugbank.ca/drugs/DB01355
DrugBank	DB01437	http://www.drugbank.ca/drugs/DB01437
DrugBank	DB01544	http://www.drugbank.ca/drugs/DB01544
DrugBank	DB01558	http://www.drugbank.ca/drugs/DB01558
DrugBank	DB01588	http://www.drugbank.ca/drugs/DB01588
DrugBank	DB01589	http://www.drugbank.ca/drugs/DB01589
DrugBank	DB01595	http://www.drugbank.ca/drugs/DB01595
EMBL	AK289461	http://www.ebi.ac.uk/ena/data/view/AK289461
EMBL	BC096241	http://www.ebi.ac.uk/ena/data/view/BC096241
EMBL	BC096242	http://www.ebi.ac.uk/ena/data/view/BC096242
EMBL	BC099640	http://www.ebi.ac.uk/ena/data/view/BC099640
EMBL	BC099641	http://www.ebi.ac.uk/ena/data/view/BC099641
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	S81944	http://www.ebi.ac.uk/ena/data/view/S81944
Ensembl	ENST00000274545	http://www.ensembl.org/id/ENST00000274545
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_component	GO:1902711	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902711
GO_function	GO:0004890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004890
GO_function	GO:0005230	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005230
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0008503	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008503
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007214	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007214
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	GABRA6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GABRA6
GeneID	2559	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2559
GeneTree	ENSGT00760000119010	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119010
H-InvDB	HIX0005382	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0005382
HGNC	HGNC:4080	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4080
HOGENOM	HOG000231337	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231337&db=HOGENOM6
HOVERGEN	HBG051707	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051707&db=HOVERGEN
HPA	CAB022462	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB022462
HPA	HPA019188	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA019188
HPA	HPA058329	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA058329
InParanoid	Q16445	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q16445
IntAct	Q16445	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q16445*
InterPro	IPR001390	http://www.ebi.ac.uk/interpro/entry/IPR001390
InterPro	IPR005436	http://www.ebi.ac.uk/interpro/entry/IPR005436
InterPro	IPR006028	http://www.ebi.ac.uk/interpro/entry/IPR006028
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
Jabion	2559	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2559
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:2559	http://www.genome.jp/dbget-bin/www_bget?hsa:2559
KEGG_Orthology	KO:K05175	http://www.genome.jp/dbget-bin/www_bget?KO:K05175
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
KEGG_Pathway	ko05032	http://www.genome.jp/kegg-bin/show_pathway?ko05032
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
MIM	137143	http://www.ncbi.nlm.nih.gov/omim/137143
OMA	PWLYIIL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PWLYIIL
OrthoDB	EOG091G0805	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0805
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00253	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00253
PRINTS	PR01079	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01079
PRINTS	PR01619	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01619
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:GBRA6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GBRA6_HUMAN
PSORT-B	swissprot:GBRA6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GBRA6_HUMAN
PSORT2	swissprot:GBRA6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GBRA6_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA28494	http://www.pharmgkb.org/do/serve?objId=PA28494&objCls=Gene
Phobius	swissprot:GBRA6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GBRA6_HUMAN
PhylomeDB	Q16445	http://phylomedb.org/?seqid=Q16445
ProteinModelPortal	Q16445	http://www.proteinmodelportal.org/query/uniprot/Q16445
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	8632757	http://www.ncbi.nlm.nih.gov/pubmed/8632757
Reactome	R-HSA-112314	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112314
Reactome	R-HSA-975298	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-975298
Reactome	R-HSA-977441	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-977441
RefSeq	NP_000802	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000802
STRING	9606.ENSP00000274545	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000274545&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc003lyu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003lyu&org=rat
UniGene	Hs.90791	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.90791
UniProtKB	GBRA6_HUMAN	http://www.uniprot.org/uniprot/GBRA6_HUMAN
UniProtKB-AC	Q16445	http://www.uniprot.org/uniprot/Q16445
charge	swissprot:GBRA6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GBRA6_HUMAN
eggNOG	ENOG410XNQG	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNQG
eggNOG	KOG3642	http://eggnogapi.embl.de/nog_data/html/tree/KOG3642
epestfind	swissprot:GBRA6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GBRA6_HUMAN
garnier	swissprot:GBRA6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GBRA6_HUMAN
helixturnhelix	swissprot:GBRA6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GBRA6_HUMAN
hmoment	swissprot:GBRA6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GBRA6_HUMAN
iep	swissprot:GBRA6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GBRA6_HUMAN
inforesidue	swissprot:GBRA6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GBRA6_HUMAN
neXtProt	NX_Q16445	http://www.nextprot.org/db/entry/NX_Q16445
octanol	swissprot:GBRA6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GBRA6_HUMAN
pepcoil	swissprot:GBRA6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GBRA6_HUMAN
pepdigest	swissprot:GBRA6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GBRA6_HUMAN
pepinfo	swissprot:GBRA6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GBRA6_HUMAN
pepnet	swissprot:GBRA6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GBRA6_HUMAN
pepstats	swissprot:GBRA6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GBRA6_HUMAN
pepwheel	swissprot:GBRA6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GBRA6_HUMAN
pepwindow	swissprot:GBRA6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GBRA6_HUMAN
sigcleave	swissprot:GBRA6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GBRA6_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O00410-1; Sequence=Displayed; Name=2; IsoId=O00410-2; Sequence=VSP_037587; Name=3; IsoId=O00410-3; Sequence=VSP_037774; Note=Ref.2 (CAA70103) sequence differs from that shown due to a frameshift in position 18. {ECO	0000305}; 
# AltName	IPO5_HUMAN	Importin subunit beta-3
# AltName	IPO5_HUMAN	Karyopherin beta-3
# AltName	IPO5_HUMAN	Ran-binding protein 5
# BioGrid	110041	102
# CCDS	CCDS31999	-. [O00410-3]
# ChiTaRS	IPO5	human
# Ensembl	ENST00000261574	ENSP00000261574; ENSG00000065150. [O00410-3]
# Ensembl	ENST00000357602	ENSP00000350219; ENSG00000065150. [O00410-1]
# Ensembl	ENST00000490680	ENSP00000418393; ENSG00000065150. [O00410-1]
# ExpressionAtlas	O00410	baseline and differential
# FUNCTION	IPO5_HUMAN	Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 and mediates its nuclear import following neuronal stimulation (By similarity). In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. {ECO 0000250|UniProtKB Q8BKC5, ECO 0000269|PubMed 9687515}. 
# GO_component	GO:0005634	nucleus; ISS:UniProtKB.
# GO_component	GO:0005643	nuclear pore; TAS:ProtInc.
# GO_component	GO:0005654	nucleoplasm; IDA:HPA.
# GO_component	GO:0005730	nucleolus; IEA:UniProtKB-SubCell.
# GO_component	GO:0005737	cytoplasm; ISS:UniProtKB.
# GO_component	GO:0005794	Golgi apparatus; IDA:HPA.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0031965	nuclear membrane; IDA:HPA.
# GO_component	GO:0034399	nuclear periphery; IBA:GO_Central.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_function	GO:0005095	GTPase inhibitor activity; TAS:ProtInc.
# GO_function	GO:0008139	nuclear localization sequence binding; IBA:GO_Central.
# GO_function	GO:0008536	Ran GTPase binding; TAS:ProtInc.
# GO_function	GO:0008565	protein transporter activity; ISS:UniProtKB.
# GO_function	GO:0044822	poly(A) RNA binding; IDA:UniProtKB.
# GO_process	GO:0000059	protein import into nucleus, docking; IBA:GO_Central.
# GO_process	GO:0000060	protein import into nucleus, translocation; IBA:GO_Central.
# GO_process	GO:0006607	NLS-bearing protein import into nucleus; ISS:UniProtKB.
# GO_process	GO:0006610	ribosomal protein import into nucleus; IDA:UniProtKB.
# GO_process	GO:0016032	viral process; IEA:UniProtKB-KW.
# GO_process	GO:0042307	positive regulation of protein import into nucleus; ISS:UniProtKB.
# GO_process	GO:0071230	cellular response to amino acid stimulus; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005730	nucleolus
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0003723	RNA binding
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0030234	enzyme regulator activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# Gene3D	1.25.10.10	-; 3.
# Genevisible	O00410	HS
# HGNC	HGNC:6402	IPO5
# INTERACTION	IPO5_HUMAN	P27958 - (xeno); NbExp=5; IntAct=EBI-356424, EBI-8753518; Q96AP0 ACD; NbExp=2; IntAct=EBI-356424, EBI-717666; O95166 GABARAP; NbExp=6; IntAct=EBI-356424, EBI-712001; Q9H0R8 GABARAPL1; NbExp=4; IntAct=EBI-356424, EBI-746969; P60520 GABARAPL2; NbExp=5; IntAct=EBI-356424, EBI-720116; Q9GZQ8 MAP1LC3B; NbExp=2; IntAct=EBI-356424, EBI-373144; Q9BXW4 MAP1LC3C; NbExp=2; IntAct=EBI-356424, EBI-2603996; P18124 RPL7; NbExp=4; IntAct=EBI-356424, EBI-350806; 
# IntAct	O00410	42
# InterPro	IPR000357	HEAT
# InterPro	IPR001494	Importin-beta_N
# InterPro	IPR011989	ARM-like
# InterPro	IPR016024	ARM-type_fold
# MIM	602008	gene
# Organism	IPO5_HUMAN	Homo sapiens (Human)
# PROSITE	PS50166	IMPORTIN_B_NT
# Pfam	PF02985	HEAT
# Proteomes	UP000005640	Chromosome 13
# Reactome	R-HSA-192905	vRNP Assembly
# RecName	IPO5_HUMAN	Importin-5
# RefSeq	NP_002262	NM_002271.4. [O00410-3]
# RefSeq	XP_005254109	XM_005254052.3. [O00410-3]
# RefSeq	XP_005254110	XM_005254053.3. [O00410-3]
# RefSeq	XP_011519389	XM_011521087.2. [O00410-3]
# RefSeq	XP_011519390	XM_011521088.2. [O00410-3]
# RefSeq	XP_011519391	XM_011521089.2. [O00410-3]
# RefSeq	XP_011519392	XM_011521090.2. [O00410-3]
# RefSeq	XP_016876051	XM_017020562.1. [O00410-3]
# SEQUENCE CAUTION	Sequence=CAA70103.1; Type=Frameshift; Positions=18; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the importin beta family. Importin beta-3 subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 importin N-terminal domain. {ECO:0000255|PROSITE-ProRule	PRU00115}. 
# SIMILARITY	IPO5_HUMAN	Contains 24 HEAT repeats. {ECO 0000250|UniProtKB P32337, ECO 0000305|PubMed 23541588}. 
# SUBCELLULAR LOCATION	IPO5_HUMAN	Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Nucleus; nuclear rim. Found particularly in the nuclear rim and nucleolus. 
# SUBUNIT	IPO5_HUMAN	Binds RPL23A, RPS7 and RPL5 (PubMed 9687515). Interacts with H2A, H2B, H3 and H4 histones (By similarity). Interacts with CPEB3; this mediates CPEB3 nuclear import following neuronal stimulation which enhances the interaction in a RAN-regulated manner (PubMed 22730302). Binds to HIV-1 Rev (PubMed 16704975). {ECO 0000250|UniProtKB Q8BKC5, ECO 0000269|PubMed 16704975, ECO 0000269|PubMed 22730302, ECO 0000269|PubMed 9687515}. 
# SUPFAM	SSF48371	SSF48371; 3
# TCDB	1.I.1.1	the nuclear pore complex (npc) family
# UCSC	uc001vne	human. [O00410-1]
# eggNOG	ENOG410XQAJ	LUCA
# eggNOG	KOG2171	Eukaryota
BLAST	swissprot:IPO5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:IPO5_HUMAN
BioCyc	ZFISH:ENSG00000065150-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000065150-MONOMER
COXPRESdb	3843	http://coxpresdb.jp/data/gene/3843.shtml
CleanEx	HS_IPO5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_IPO5
DIP	DIP-41042N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-41042N
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.jmb.2013.02.035	http://dx.doi.org/10.1016/j.jmb.2013.02.035
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature02379	http://dx.doi.org/10.1038/nature02379
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1073/pnas.94.9.4451	http://dx.doi.org/10.1073/pnas.94.9.4451
DOI	10.1074/jbc.M602189200	http://dx.doi.org/10.1074/jbc.M602189200
DOI	10.1074/mcp.M111.015131	http://dx.doi.org/10.1074/mcp.M111.015131
DOI	10.1093/emboj/17.15.4491	http://dx.doi.org/10.1093/emboj/17.15.4491
DOI	10.1093/nar/gks598	http://dx.doi.org/10.1093/nar/gks598
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1128/MCB.17.9.5087	http://dx.doi.org/10.1128/MCB.17.9.5087
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AK302812	http://www.ebi.ac.uk/ena/data/view/AK302812
EMBL	AL137120	http://www.ebi.ac.uk/ena/data/view/AL137120
EMBL	AL137120	http://www.ebi.ac.uk/ena/data/view/AL137120
EMBL	AL356580	http://www.ebi.ac.uk/ena/data/view/AL356580
EMBL	AL356580	http://www.ebi.ac.uk/ena/data/view/AL356580
EMBL	BC001497	http://www.ebi.ac.uk/ena/data/view/BC001497
EMBL	BC019309	http://www.ebi.ac.uk/ena/data/view/BC019309
EMBL	BC045640	http://www.ebi.ac.uk/ena/data/view/BC045640
EMBL	CH471085	http://www.ebi.ac.uk/ena/data/view/CH471085
EMBL	U72761	http://www.ebi.ac.uk/ena/data/view/U72761
EMBL	Y08890	http://www.ebi.ac.uk/ena/data/view/Y08890
Ensembl	ENST00000261574	http://www.ensembl.org/id/ENST00000261574
Ensembl	ENST00000357602	http://www.ensembl.org/id/ENST00000357602
Ensembl	ENST00000490680	http://www.ensembl.org/id/ENST00000490680
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005643	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005643
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005730
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0031965	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031965
GO_component	GO:0034399	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034399
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0005095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005095
GO_function	GO:0008139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008139
GO_function	GO:0008536	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008536
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0044822	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044822
GO_process	GO:0000059	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000059
GO_process	GO:0000060	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000060
GO_process	GO:0006607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006607
GO_process	GO:0006610	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006610
GO_process	GO:0016032	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016032
GO_process	GO:0042307	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042307
GO_process	GO:0071230	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071230
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005730
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0003723	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0030234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
GeneCards	IPO5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=IPO5
GeneID	3843	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3843
GeneTree	ENSGT00550000074773	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074773
H-InvDB	HIX0174410	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0174410
HGNC	HGNC:6402	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6402
HOGENOM	HOG000209725	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000209725&db=HOGENOM6
HOVERGEN	HBG006156	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006156&db=HOVERGEN
HPA	CAB009110	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB009110
HPA	HPA040983	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA040983
HPA	HPA056548	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA056548
InParanoid	O00410	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O00410
IntAct	O00410	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O00410*
InterPro	IPR000357	http://www.ebi.ac.uk/interpro/entry/IPR000357
InterPro	IPR001494	http://www.ebi.ac.uk/interpro/entry/IPR001494
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
Jabion	3843	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3843
KEGG_Gene	hsa:3843	http://www.genome.jp/dbget-bin/www_bget?hsa:3843
MIM	602008	http://www.ncbi.nlm.nih.gov/omim/602008
MINT	MINT-132356	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-132356
OMA	NLNNMQR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NLNNMQR
OrthoDB	EOG091G011X	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G011X
PROSITE	PS50166	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50166
PSORT	swissprot:IPO5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:IPO5_HUMAN
PSORT-B	swissprot:IPO5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:IPO5_HUMAN
PSORT2	swissprot:IPO5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:IPO5_HUMAN
Pfam	PF02985	http://pfam.xfam.org/family/PF02985
PharmGKB	PA30193	http://www.pharmgkb.org/do/serve?objId=PA30193&objCls=Gene
Phobius	swissprot:IPO5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:IPO5_HUMAN
PhylomeDB	O00410	http://phylomedb.org/?seqid=O00410
ProteinModelPortal	O00410	http://www.proteinmodelportal.org/query/uniprot/O00410
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15057823	http://www.ncbi.nlm.nih.gov/pubmed/15057823
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16704975	http://www.ncbi.nlm.nih.gov/pubmed/16704975
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22223895	http://www.ncbi.nlm.nih.gov/pubmed/22223895
PubMed	22730302	http://www.ncbi.nlm.nih.gov/pubmed/22730302
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	23541588	http://www.ncbi.nlm.nih.gov/pubmed/23541588
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	9114010	http://www.ncbi.nlm.nih.gov/pubmed/9114010
PubMed	9271386	http://www.ncbi.nlm.nih.gov/pubmed/9271386
PubMed	9687515	http://www.ncbi.nlm.nih.gov/pubmed/9687515
Reactome	R-HSA-192905	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-192905
RefSeq	NP_002262	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002262
RefSeq	XP_005254109	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005254109
RefSeq	XP_005254110	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005254110
RefSeq	XP_011519389	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011519389
RefSeq	XP_011519390	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011519390
RefSeq	XP_011519391	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011519391
RefSeq	XP_011519392	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011519392
RefSeq	XP_016876051	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016876051
SMR	O00410	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O00410
STRING	9606.ENSP00000261574	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000261574&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
TCDB	1.I.1.1	http://www.tcdb.org/search/result.php?tc=1.I.1.1
UCSC	uc001vne	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001vne&org=rat
UniGene	Hs.712598	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.712598
UniProtKB	IPO5_HUMAN	http://www.uniprot.org/uniprot/IPO5_HUMAN
UniProtKB-AC	O00410	http://www.uniprot.org/uniprot/O00410
charge	swissprot:IPO5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:IPO5_HUMAN
eggNOG	ENOG410XQAJ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQAJ
eggNOG	KOG2171	http://eggnogapi.embl.de/nog_data/html/tree/KOG2171
epestfind	swissprot:IPO5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:IPO5_HUMAN
garnier	swissprot:IPO5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:IPO5_HUMAN
helixturnhelix	swissprot:IPO5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:IPO5_HUMAN
hmoment	swissprot:IPO5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:IPO5_HUMAN
iep	swissprot:IPO5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:IPO5_HUMAN
inforesidue	swissprot:IPO5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:IPO5_HUMAN
neXtProt	NX_O00410	http://www.nextprot.org/db/entry/NX_O00410
octanol	swissprot:IPO5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:IPO5_HUMAN
pepcoil	swissprot:IPO5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:IPO5_HUMAN
pepdigest	swissprot:IPO5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:IPO5_HUMAN
pepinfo	swissprot:IPO5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:IPO5_HUMAN
pepnet	swissprot:IPO5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:IPO5_HUMAN
pepstats	swissprot:IPO5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:IPO5_HUMAN
pepwheel	swissprot:IPO5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:IPO5_HUMAN
pepwindow	swissprot:IPO5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:IPO5_HUMAN
sigcleave	swissprot:IPO5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:IPO5_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SL9A6_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q92581-1; Sequence=Displayed; Name=2; IsoId=Q92581-2; Sequence=VSP_042030; Name=3; IsoId=Q92581-3; Sequence=VSP_044868, VSP_042030; Note=No experimental confirmation available.; 
# AltName	SL9A6_HUMAN	Na(+)/H(+) exchanger 6
# AltName	SL9A6_HUMAN	Solute carrier family 9 member 6
# BioGrid	115742	30
# CAUTION	SL9A6_HUMAN	Was originally (PubMed 9507001) identified as a mitochondrial inner membrane protein, but was later shown to be localized in early and recycling endosomes and not mitochondria (PubMed 11940519). {ECO 0000305|PubMed 11940519, ECO 0000305|PubMed 9507001}.
# CCDS	CCDS14654	-. [Q92581-1]
# CCDS	CCDS44003	-. [Q92581-2]
# CCDS	CCDS55504	-. [Q92581-3]
# DISEASE	SL9A6_HUMAN	Mental retardation, X-linked, syndromic, Christianson type (MRXSCH) [MIM 300243]  A syndrome characterized by profound mental retardation, epilepsy, ataxia, and microcephaly. It shows phenotypic overlap with Angelman syndrome. {ECO 0000269|PubMed 18342287, ECO 0000269|PubMed 24123876}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000370695	ENSP00000359729; ENSG00000198689. [Q92581-2]
# Ensembl	ENST00000370698	ENSP00000359732; ENSG00000198689. [Q92581-1]
# Ensembl	ENST00000370701	ENSP00000359735; ENSG00000198689. [Q92581-3]
# Ensembl	ENST00000636092	ENSP00000490406; ENSG00000198689. [Q92581-3]
# Ensembl	ENST00000636347	ENSP00000490648; ENSG00000198689. [Q92581-3]
# Ensembl	ENST00000637234	ENSP00000490527; ENSG00000198689. [Q92581-3]
# Ensembl	ENST00000637581	ENSP00000490731; ENSG00000198689. [Q92581-3]
# ExpressionAtlas	Q92581	baseline and differential
# FUNCTION	SL9A6_HUMAN	Electroneutral exchange of protons for Na(+) and K(+) across the early and recycling endosome membranes. Contributes to calcium homeostasis. 
# GO_component	GO:0005770	late endosome; IEA:Ensembl.
# GO_component	GO:0005789	endoplasmic reticulum membrane; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0030425	dendrite; IEA:Ensembl.
# GO_component	GO:0031410	cytoplasmic vesicle; IEA:Ensembl.
# GO_component	GO:0031901	early endosome membrane; IDA:UniProtKB.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_component	GO:0043679	axon terminus; IEA:Ensembl.
# GO_component	GO:0044308	axonal spine; IEA:Ensembl.
# GO_component	GO:0045202	synapse; IEA:Ensembl.
# GO_component	GO:0055038	recycling endosome membrane; IDA:UniProtKB.
# GO_function	SL9A6_HUMAN	GO 0015385 sodium proton antiporter activity; TAS Reactome.
# GO_function	SL9A6_HUMAN	GO 0015386 potassium proton antiporter activity; IBA GO_Central.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0031547	brain-derived neurotrophic factor receptor signaling pathway; IEA:Ensembl.
# GO_process	GO:0048675	axon extension; IDA:MGI.
# GO_process	GO:0048812	neuron projection morphogenesis; IDA:MGI.
# GO_process	GO:0050808	synapse organization; IEA:Ensembl.
# GO_process	GO:0051386	regulation of neurotrophin TRK receptor signaling pathway; IEA:Ensembl.
# GO_process	GO:0051453	regulation of intracellular pH; IBA:GO_Central.
# GO_process	GO:0060996	dendritic spine development; IEA:Ensembl.
# GO_process	GO:0071805	potassium ion transmembrane transport; IBA:GO_Central.
# GO_process	GO:0097484	dendrite extension; IDA:MGI.
# GO_process	GO:0098719	sodium ion import across plasma membrane; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0040007	growth
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q92581	HS
# HGNC	HGNC:11079	SLC9A6
# InterPro	IPR002090	Na/H_exchanger_6
# InterPro	IPR004709	NaH_exchanger
# InterPro	IPR006153	Cation/H_exchanger
# InterPro	IPR018422	Cation/H_exchanger_CPA1
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H00577	[Congenital disorder; Mental retardation; Epilepsy] Rolandic epilepsy
# MIM	300231	gene
# MIM	300243	phenotype
# Organism	SL9A6_HUMAN	Homo sapiens (Human)
# Orphanet	85278	Christianson syndrome
# PANTHER	PTHR10110	PTHR10110
# PRINTS	PR01084	NAHEXCHNGR
# PRINTS	PR01088	NAHEXCHNGR6
# Pfam	PF00999	Na_H_Exchanger
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-425986	Sodium/Proton exchangers
# RecName	SL9A6_HUMAN	Sodium/hydrogen exchanger 6
# RefSeq	NP_001036002	NM_001042537.1. [Q92581-2]
# RefSeq	NP_001171122	NM_001177651.1. [Q92581-3]
# RefSeq	NP_006350	NM_006359.2. [Q92581-1]
# RefSeq	XP_006724789	XM_006724726.3. [Q92581-3]
# RefSeq	XP_016884712	XM_017029223.1. [Q92581-3]
# RefSeq	XP_016884713	XM_017029224.1. [Q92581-3]
# SIMILARITY	Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	SL9A6_HUMAN	Endosome membrane {ECO 0000269|PubMed 11940519}; Multi-pass membrane protein {ECO 0000269|PubMed 11940519}. Note=Is present in the recycling compartments including early and recycling endosomes, and only appears transiently on the plasma membrane. 
# TCDB	2.A.36.1.14:the monovalent cation	proton antiporter-1 (cpa1) family
# TIGRFAMs	TIGR00840	b_cpa1
# TISSUE SPECIFICITY	SL9A6_HUMAN	Ubiquitous; but is most abundant in mitochondrion-rich tissues such as brain, skeletal muscle and heart. 
# UCSC	uc004ezj	human. [Q92581-1]
# eggNOG	COG0025	LUCA
# eggNOG	KOG1965	Eukaryota
BLAST	swissprot:SL9A6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SL9A6_HUMAN
BioCyc	ZFISH:G66-33153-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33153-MONOMER
COXPRESdb	10479	http://coxpresdb.jp/data/gene/10479.shtml
CleanEx	HS_SLC9A6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC9A6
DOI	10.1002/pmic.200600410	http://dx.doi.org/10.1002/pmic.200600410
DOI	10.1016/j.ajhg.2008.01.013	http://dx.doi.org/10.1016/j.ajhg.2008.01.013
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.273.12.6951	http://dx.doi.org/10.1074/jbc.273.12.6951
DOI	10.1093/dnares/3.5.321	http://dx.doi.org/10.1093/dnares/3.5.321
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1136/jmedgenet-2013-101644	http://dx.doi.org/10.1136/jmedgenet-2013-101644
DOI	10.1152/ajpcell.00420.2001	http://dx.doi.org/10.1152/ajpcell.00420.2001
EMBL	AF030409	http://www.ebi.ac.uk/ena/data/view/AF030409
EMBL	AK289775	http://www.ebi.ac.uk/ena/data/view/AK289775
EMBL	AK300475	http://www.ebi.ac.uk/ena/data/view/AK300475
EMBL	AK316255	http://www.ebi.ac.uk/ena/data/view/AK316255
EMBL	AL732579	http://www.ebi.ac.uk/ena/data/view/AL732579
EMBL	AL732579	http://www.ebi.ac.uk/ena/data/view/AL732579
EMBL	AL732579	http://www.ebi.ac.uk/ena/data/view/AL732579
EMBL	BC035029	http://www.ebi.ac.uk/ena/data/view/BC035029
EMBL	BC049169	http://www.ebi.ac.uk/ena/data/view/BC049169
EMBL	D87743	http://www.ebi.ac.uk/ena/data/view/D87743
Ensembl	ENST00000370695	http://www.ensembl.org/id/ENST00000370695
Ensembl	ENST00000370698	http://www.ensembl.org/id/ENST00000370698
Ensembl	ENST00000370701	http://www.ensembl.org/id/ENST00000370701
Ensembl	ENST00000636092	http://www.ensembl.org/id/ENST00000636092
Ensembl	ENST00000636347	http://www.ensembl.org/id/ENST00000636347
Ensembl	ENST00000637234	http://www.ensembl.org/id/ENST00000637234
Ensembl	ENST00000637581	http://www.ensembl.org/id/ENST00000637581
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005770	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005770
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GO_component	GO:0031901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031901
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_component	GO:0043679	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043679
GO_component	GO:0044308	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044308
GO_component	GO:0045202	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045202
GO_component	GO:0055038	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055038
GO_function	GO:0015385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015385
GO_function	GO:0015386	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015386
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0031547	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031547
GO_process	GO:0048675	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048675
GO_process	GO:0048812	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048812
GO_process	GO:0050808	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050808
GO_process	GO:0051386	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051386
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GO_process	GO:0060996	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060996
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GO_process	GO:0097484	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097484
GO_process	GO:0098719	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098719
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0040007	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040007
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC9A6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC9A6
GeneID	10479	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10479
GeneTree	ENSGT00760000119074	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119074
HGNC	HGNC:11079	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11079
HOGENOM	HOG000172307	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000172307&db=HOGENOM6
HOVERGEN	HBG055575	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG055575&db=HOVERGEN
HPA	HPA059445	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA059445
HPA	HPA059590	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA059590
InParanoid	Q92581	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q92581
InterPro	IPR002090	http://www.ebi.ac.uk/interpro/entry/IPR002090
InterPro	IPR004709	http://www.ebi.ac.uk/interpro/entry/IPR004709
InterPro	IPR006153	http://www.ebi.ac.uk/interpro/entry/IPR006153
InterPro	IPR018422	http://www.ebi.ac.uk/interpro/entry/IPR018422
Jabion	10479	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10479
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00577	http://www.genome.jp/dbget-bin/www_bget?H00577
KEGG_Gene	hsa:10479	http://www.genome.jp/dbget-bin/www_bget?hsa:10479
KEGG_Orthology	KO:K12041	http://www.genome.jp/dbget-bin/www_bget?KO:K12041
MIM	300231	http://www.ncbi.nlm.nih.gov/omim/300231
MIM	300243	http://www.ncbi.nlm.nih.gov/omim/300243
OMA	GVFDWAG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GVFDWAG
Orphanet	85278	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=85278
OrthoDB	EOG091G0HN5	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0HN5
PANTHER	PTHR10110	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10110
PRINTS	PR01084	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01084
PRINTS	PR01088	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01088
PSORT	swissprot:SL9A6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SL9A6_HUMAN
PSORT-B	swissprot:SL9A6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SL9A6_HUMAN
PSORT2	swissprot:SL9A6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SL9A6_HUMAN
Pfam	PF00999	http://pfam.xfam.org/family/PF00999
PharmGKB	PA35935	http://www.pharmgkb.org/do/serve?objId=PA35935&objCls=Gene
Phobius	swissprot:SL9A6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SL9A6_HUMAN
PhylomeDB	Q92581	http://phylomedb.org/?seqid=Q92581
ProteinModelPortal	Q92581	http://www.proteinmodelportal.org/query/uniprot/Q92581
PubMed	11940519	http://www.ncbi.nlm.nih.gov/pubmed/11940519
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	17370265	http://www.ncbi.nlm.nih.gov/pubmed/17370265
PubMed	18342287	http://www.ncbi.nlm.nih.gov/pubmed/18342287
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	24123876	http://www.ncbi.nlm.nih.gov/pubmed/24123876
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	9039502	http://www.ncbi.nlm.nih.gov/pubmed/9039502
PubMed	9507001	http://www.ncbi.nlm.nih.gov/pubmed/9507001
Reactome	R-HSA-425986	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425986
RefSeq	NP_001036002	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001036002
RefSeq	NP_001171122	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001171122
RefSeq	NP_006350	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006350
RefSeq	XP_006724789	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006724789
RefSeq	XP_016884712	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016884712
RefSeq	XP_016884713	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016884713
SMR	Q92581	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q92581
STRING	9606.ENSP00000359729	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000359729&targetmode=cogs
TCDB	2.A.36.1.14	http://www.tcdb.org/search/result.php?tc=2.A.36.1.14
TIGRFAMs	TIGR00840	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00840
UCSC	uc004ezj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004ezj&org=rat
UniGene	Hs.62185	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.62185
UniProtKB	SL9A6_HUMAN	http://www.uniprot.org/uniprot/SL9A6_HUMAN
UniProtKB-AC	Q92581	http://www.uniprot.org/uniprot/Q92581
charge	swissprot:SL9A6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SL9A6_HUMAN
eggNOG	COG0025	http://eggnogapi.embl.de/nog_data/html/tree/COG0025
eggNOG	KOG1965	http://eggnogapi.embl.de/nog_data/html/tree/KOG1965
epestfind	swissprot:SL9A6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SL9A6_HUMAN
garnier	swissprot:SL9A6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SL9A6_HUMAN
helixturnhelix	swissprot:SL9A6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SL9A6_HUMAN
hmoment	swissprot:SL9A6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SL9A6_HUMAN
iep	swissprot:SL9A6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SL9A6_HUMAN
inforesidue	swissprot:SL9A6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SL9A6_HUMAN
neXtProt	NX_Q92581	http://www.nextprot.org/db/entry/NX_Q92581
octanol	swissprot:SL9A6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SL9A6_HUMAN
pepcoil	swissprot:SL9A6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SL9A6_HUMAN
pepdigest	swissprot:SL9A6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SL9A6_HUMAN
pepinfo	swissprot:SL9A6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SL9A6_HUMAN
pepnet	swissprot:SL9A6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SL9A6_HUMAN
pepstats	swissprot:SL9A6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SL9A6_HUMAN
pepwheel	swissprot:SL9A6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SL9A6_HUMAN
pepwindow	swissprot:SL9A6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SL9A6_HUMAN
sigcleave	swissprot:SL9A6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SL9A6_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	MFRN1_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9NYZ2-1; Sequence=Displayed; Name=2; IsoId=Q9NYZ2-2; Sequence=VSP_018402, VSP_018403; Name=4; IsoId=Q9NYZ2-4; Sequence=VSP_018400; Note=No experimental confirmation available.; 
# AltName	MFRN1_HUMAN	Mitochondrial iron transporter 1
# AltName	MFRN1_HUMAN	Mitochondrial solute carrier protein
# AltName	MFRN1_HUMAN	Solute carrier family 25 member 37
# CCDS	CCDS47828	-. [Q9NYZ2-1]
# ChiTaRS	SLC25A37	human
# Ensembl	ENST00000290075	ENSP00000290075; ENSG00000147454. [Q9NYZ2-2]
# Ensembl	ENST00000519973	ENSP00000429200; ENSG00000147454. [Q9NYZ2-1]
# ExpressionAtlas	Q9NYZ2	baseline and differential
# FUNCTION	MFRN1_HUMAN	Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity). {ECO 0000250}. 
# GO_component	GO:0005743	mitochondrial inner membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015093	ferrous iron transmembrane transporter activity; IEA:Ensembl.
# GO_process	GO:0048250	mitochondrial iron ion transport; IEA:Ensembl.
# GO_process	GO:0055072	iron ion homeostasis; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0042592	homeostatic process
# Gene3D	1.50.40.10	-; 1.
# Genevisible	Q9NYZ2	HS
# HGNC	HGNC:29786	SLC25A37
# InterPro	IPR018108	Mitochondrial_sb/sol_carrier
# InterPro	IPR023395	Mt_carrier_dom
# KEGG_Brite	ko02001	Solute carrier family
# MIM	610387	gene
# Organism	MFRN1_HUMAN	Homo sapiens (Human)
# PROSITE	PS50920	SOLCAR; 3
# Pfam	PF00153	Mito_carr; 3
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-1362409	Mitochondrial iron-sulfur cluster biogenesis
# RecName	MFRN1_HUMAN	Mitoferrin-1
# RefSeq	NP_001304741	NM_001317812.1. [Q9NYZ2-4]
# RefSeq	NP_001304742	NM_001317813.1
# RefSeq	NP_001304743	NM_001317814.1
# RefSeq	NP_057696	NM_016612.3. [Q9NYZ2-1]
# RefSeq	XP_011542856	XM_011544554.2. [Q9NYZ2-4]
# SEQUENCE CAUTION	Sequence=AAF64141.1; Type=Frameshift; Positions=296; Evidence={ECO:0000305}; Sequence=CAH10415.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the mitochondrial carrier (TC 2.A.29) family. {ECO	0000305}. 
# SIMILARITY	Contains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule	PRU00282}. 
# SUBCELLULAR LOCATION	MFRN1_HUMAN	Mitochondrion inner membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUPFAM	SSF103506	SSF103506
# TCDB	2.A.29.5	the mitochondrial carrier (mc) family
# UCSC	uc003xds	human. [Q9NYZ2-1]
# eggNOG	ENOG410XNT2	LUCA
# eggNOG	KOG0760	Eukaryota
BLAST	swissprot:MFRN1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MFRN1_HUMAN
COXPRESdb	51312	http://coxpresdb.jp/data/gene/51312.shtml
CleanEx	HS_SLC25A37	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC25A37
DOI	10.1007/s00335001-2075-1	http://dx.doi.org/10.1007/s00335001-2075-1
DOI	10.1073/pnas.160270997	http://dx.doi.org/10.1073/pnas.160270997
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AF155660	http://www.ebi.ac.uk/ena/data/view/AF155660
EMBL	AF223466	http://www.ebi.ac.uk/ena/data/view/AF223466
EMBL	AK223194	http://www.ebi.ac.uk/ena/data/view/AK223194
EMBL	AL833186	http://www.ebi.ac.uk/ena/data/view/AL833186
EMBL	AY032628	http://www.ebi.ac.uk/ena/data/view/AY032628
EMBL	BC015013	http://www.ebi.ac.uk/ena/data/view/BC015013
EMBL	BC132799	http://www.ebi.ac.uk/ena/data/view/BC132799
EMBL	BC132801	http://www.ebi.ac.uk/ena/data/view/BC132801
EMBL	CH471080	http://www.ebi.ac.uk/ena/data/view/CH471080
Ensembl	ENST00000290075	http://www.ensembl.org/id/ENST00000290075
Ensembl	ENST00000519973	http://www.ensembl.org/id/ENST00000519973
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015093	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015093
GO_process	GO:0048250	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048250
GO_process	GO:0055072	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
Gene3D	1.50.40.10	http://www.cathdb.info/version/latest/superfamily/1.50.40.10
GeneCards	SLC25A37	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC25A37
GeneID	51312	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51312
GeneTree	ENSGT00550000074721	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074721
H-InvDB	HIX0007389	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0007389
HGNC	HGNC:29786	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:29786
HOGENOM	HOG000171727	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000171727&db=HOGENOM6
HOVERGEN	HBG079464	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG079464&db=HOVERGEN
HPA	HPA045680	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA045680
InParanoid	Q9NYZ2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NYZ2
InterPro	IPR018108	http://www.ebi.ac.uk/interpro/entry/IPR018108
InterPro	IPR023395	http://www.ebi.ac.uk/interpro/entry/IPR023395
Jabion	51312	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=51312
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:51312	http://www.genome.jp/dbget-bin/www_bget?hsa:51312
KEGG_Orthology	KO:K15113	http://www.genome.jp/dbget-bin/www_bget?KO:K15113
MIM	610387	http://www.ncbi.nlm.nih.gov/omim/610387
OMA	PRRDYNP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PRRDYNP
OrthoDB	EOG091G0PU8	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0PU8
PROSITE	PS50920	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50920
PSORT	swissprot:MFRN1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MFRN1_HUMAN
PSORT-B	swissprot:MFRN1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MFRN1_HUMAN
PSORT2	swissprot:MFRN1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MFRN1_HUMAN
Pfam	PF00153	http://pfam.xfam.org/family/PF00153
PharmGKB	PA142670909	http://www.pharmgkb.org/do/serve?objId=PA142670909&objCls=Gene
Phobius	swissprot:MFRN1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MFRN1_HUMAN
PhylomeDB	Q9NYZ2	http://phylomedb.org/?seqid=Q9NYZ2
ProteinModelPortal	Q9NYZ2	http://www.proteinmodelportal.org/query/uniprot/Q9NYZ2
PubMed	10931946	http://www.ncbi.nlm.nih.gov/pubmed/10931946
PubMed	11845285	http://www.ncbi.nlm.nih.gov/pubmed/11845285
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
Reactome	R-HSA-1362409	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1362409
RefSeq	NP_001304741	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001304741
RefSeq	NP_001304742	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001304742
RefSeq	NP_001304743	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001304743
RefSeq	NP_057696	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_057696
RefSeq	XP_011542856	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011542856
STRING	9606.ENSP00000429200	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000429200&targetmode=cogs
SUPFAM	SSF103506	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103506
TCDB	2.A.29.5	http://www.tcdb.org/search/result.php?tc=2.A.29.5
UCSC	uc003xds	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003xds&org=rat
UniGene	Hs.596025	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.596025
UniGene	Hs.658208	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.658208
UniGene	Hs.726050	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.726050
UniProtKB	MFRN1_HUMAN	http://www.uniprot.org/uniprot/MFRN1_HUMAN
UniProtKB-AC	Q9NYZ2	http://www.uniprot.org/uniprot/Q9NYZ2
charge	swissprot:MFRN1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MFRN1_HUMAN
eggNOG	ENOG410XNT2	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNT2
eggNOG	KOG0760	http://eggnogapi.embl.de/nog_data/html/tree/KOG0760
epestfind	swissprot:MFRN1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MFRN1_HUMAN
garnier	swissprot:MFRN1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MFRN1_HUMAN
helixturnhelix	swissprot:MFRN1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MFRN1_HUMAN
hmoment	swissprot:MFRN1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MFRN1_HUMAN
iep	swissprot:MFRN1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MFRN1_HUMAN
inforesidue	swissprot:MFRN1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MFRN1_HUMAN
neXtProt	NX_Q9NYZ2	http://www.nextprot.org/db/entry/NX_Q9NYZ2
octanol	swissprot:MFRN1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MFRN1_HUMAN
pepcoil	swissprot:MFRN1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MFRN1_HUMAN
pepdigest	swissprot:MFRN1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MFRN1_HUMAN
pepinfo	swissprot:MFRN1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MFRN1_HUMAN
pepnet	swissprot:MFRN1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MFRN1_HUMAN
pepstats	swissprot:MFRN1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MFRN1_HUMAN
pepwheel	swissprot:MFRN1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MFRN1_HUMAN
pepwindow	swissprot:MFRN1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MFRN1_HUMAN
sigcleave	swissprot:MFRN1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MFRN1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9BZC7-1; Sequence=Displayed; Name=2; IsoId=Q9BZC7-2; Sequence=VSP_035283, VSP_035284; Note=No experimental confirmation available.; Name=3; IsoId=Q9BZC7-3; Sequence=VSP_040937; Note=Ref.1 (AAK14334/AAK14335) and Ref.2 (AAG09372) sequences are in conflict in position: 55	S->P. {ECO:0000305}; 
# AltName	ABCA2_HUMAN	ATP-binding cassette transporter 2
# BioGrid	106538	21
# CCDS	CCDS43909	-. [Q9BZC7-3]
# ChiTaRS	ABCA2	human
# Ensembl	ENST00000341511	ENSP00000344155; ENSG00000107331
# Ensembl	ENST00000371605	ENSP00000360666; ENSG00000107331
# ExpressionAtlas	Q9BZC7	baseline and differential
# FUNCTION	ABCA2_HUMAN	Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development. 
# GO_component	GO:0005764	lysosome; IDA:UniProtKB.
# GO_component	GO:0005765	lysosomal membrane; NAS:UniProtKB.
# GO_component	GO:0005768	endosome; IDA:UniProtKB.
# GO_component	GO:0005815	microtubule organizing center; ISS:UniProtKB.
# GO_component	GO:0010008	endosome membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IDA:UniProtKB.
# GO_component	GO:0016023	cytoplasmic, membrane-bounded vesicle; ISS:UniProtKB.
# GO_component	GO:0043190	ATP-binding cassette (ABC) transporter complex; NAS:UniProtKB.
# GO_function	GO:0000166	nucleotide binding; NAS:UniProtKB.
# GO_function	GO:0005524	ATP binding; IDA:UniProtKB.
# GO_function	GO:0016887	ATPase activity; IDA:UniProtKB.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; NAS:UniProtKB.
# GO_process	GO:0006357	regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
# GO_process	GO:0006629	lipid metabolic process; NAS:UniProtKB.
# GO_process	GO:0006810	transport; NAS:UniProtKB.
# GO_process	GO:0032383	regulation of intracellular cholesterol transport; IMP:UniProtKB.
# GO_process	GO:0033344	cholesterol efflux; IBA:GO_Central.
# GO_process	GO:0033700	phospholipid efflux; IBA:GO_Central.
# GO_process	GO:0042493	response to drug; TAS:UniProtKB.
# GO_process	GO:0042632	cholesterol homeostasis; IEP:UniProtKB.
# GO_process	GO:0048545	response to steroid hormone; IEP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005764	lysosome
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005815	microtubule organizing center
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# Gene3D	3.40.50.300	-; 2.
# Genevisible	Q9BZC7	HS
# HGNC	HGNC:32	ABCA2
# IntAct	Q9BZC7	16
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR026082	ABC_A
# InterPro	IPR027417	P-loop_NTPase
# InterPro	IPR030366	ABCA2
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko02010	ABC transporters
# KEGG_Pathway	ko04142	Lysosome
# MIM	600047	gene
# Organism	ABCA2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR19229	PTHR19229; 5
# PANTHER	PTHR19229:SF116	PTHR19229:SF116; 5
# PIR	A59189	A59189
# PROSITE	PS00211	ABC_TRANSPORTER_1
# PROSITE	PS50893	ABC_TRANSPORTER_2; 2
# Pfam	PF00005	ABC_tran; 2
# Proteomes	UP000005640	Chromosome 9
# Reactome	R-HSA-1369062	ABC transporters in lipid homeostasis
# RecName	ABCA2_HUMAN	ATP-binding cassette sub-family A member 2
# RefSeq	NP_001597	NM_001606.4
# RefSeq	NP_997698	NM_212533.2
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCA family. {ECO	0000305}. 
# SIMILARITY	Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA; 2
# SUBCELLULAR LOCATION	ABCA2_HUMAN	Endosome membrane {ECO 0000269|PubMed 11309290}; Multi-pass membrane protein {ECO 0000269|PubMed 11309290}. Lysosome membrane {ECO 0000269|PubMed 11309290}; Multi-pass membrane protein {ECO 0000269|PubMed 11309290}. Note=Forms discrete, punctate intracellular vesicles. 
# SUPFAM	SSF52540	SSF52540; 2
# TCDB	3.A.1.211	the atp-binding cassette (abc) superfamily
# TISSUE SPECIFICITY	Highly expressed in the brain, whereas lower levels of expression is observed in kidney and liver. {ECO:0000269|PubMed	11309290}. 
# UCSC	uc011mem	human. [Q9BZC7-1]
# WEB RESOURCE	ABCA2_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=Q9BZC7";
# eggNOG	COG1131	LUCA
# eggNOG	KOG0059	Eukaryota
BLAST	swissprot:ABCA2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCA2_HUMAN
BioCyc	ZFISH:ENSG00000107331-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000107331-MONOMER
COXPRESdb	20	http://coxpresdb.jp/data/gene/20.shtml
CleanEx	HS_ABCA2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCA2
DOI	10.1006/bbrc.2001.4305	http://dx.doi.org/10.1006/bbrc.2001.4305
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1093/dnares/6.3.197	http://dx.doi.org/10.1093/dnares/6.3.197
DOI	10.1093/dnares/9.3.99	http://dx.doi.org/10.1093/dnares/9.3.99
EMBL	AB028985	http://www.ebi.ac.uk/ena/data/view/AB028985
EMBL	AB177854	http://www.ebi.ac.uk/ena/data/view/AB177854
EMBL	AF178941	http://www.ebi.ac.uk/ena/data/view/AF178941
EMBL	AF327657	http://www.ebi.ac.uk/ena/data/view/AF327657
EMBL	AF327658	http://www.ebi.ac.uk/ena/data/view/AF327658
EMBL	AF327659	http://www.ebi.ac.uk/ena/data/view/AF327659
EMBL	AF327660	http://www.ebi.ac.uk/ena/data/view/AF327660
EMBL	AF327661	http://www.ebi.ac.uk/ena/data/view/AF327661
EMBL	AF327662	http://www.ebi.ac.uk/ena/data/view/AF327662
EMBL	AF327663	http://www.ebi.ac.uk/ena/data/view/AF327663
EMBL	AF327664	http://www.ebi.ac.uk/ena/data/view/AF327664
EMBL	AF327665	http://www.ebi.ac.uk/ena/data/view/AF327665
EMBL	AF327666	http://www.ebi.ac.uk/ena/data/view/AF327666
EMBL	AF327667	http://www.ebi.ac.uk/ena/data/view/AF327667
EMBL	AF327668	http://www.ebi.ac.uk/ena/data/view/AF327668
EMBL	AF327669	http://www.ebi.ac.uk/ena/data/view/AF327669
EMBL	AF327670	http://www.ebi.ac.uk/ena/data/view/AF327670
EMBL	AF327671	http://www.ebi.ac.uk/ena/data/view/AF327671
EMBL	AF327672	http://www.ebi.ac.uk/ena/data/view/AF327672
EMBL	AF327673	http://www.ebi.ac.uk/ena/data/view/AF327673
EMBL	AF327674	http://www.ebi.ac.uk/ena/data/view/AF327674
EMBL	AF327675	http://www.ebi.ac.uk/ena/data/view/AF327675
EMBL	AF327676	http://www.ebi.ac.uk/ena/data/view/AF327676
EMBL	AF327677	http://www.ebi.ac.uk/ena/data/view/AF327677
EMBL	AF327678	http://www.ebi.ac.uk/ena/data/view/AF327678
EMBL	AF327679	http://www.ebi.ac.uk/ena/data/view/AF327679
EMBL	AF327680	http://www.ebi.ac.uk/ena/data/view/AF327680
EMBL	AF327681	http://www.ebi.ac.uk/ena/data/view/AF327681
EMBL	AF327682	http://www.ebi.ac.uk/ena/data/view/AF327682
EMBL	AF327683	http://www.ebi.ac.uk/ena/data/view/AF327683
EMBL	AF327684	http://www.ebi.ac.uk/ena/data/view/AF327684
EMBL	AF327685	http://www.ebi.ac.uk/ena/data/view/AF327685
EMBL	AF327686	http://www.ebi.ac.uk/ena/data/view/AF327686
EMBL	AF327687	http://www.ebi.ac.uk/ena/data/view/AF327687
EMBL	AF327688	http://www.ebi.ac.uk/ena/data/view/AF327688
EMBL	AF327689	http://www.ebi.ac.uk/ena/data/view/AF327689
EMBL	AF327690	http://www.ebi.ac.uk/ena/data/view/AF327690
EMBL	AF327691	http://www.ebi.ac.uk/ena/data/view/AF327691
EMBL	AF327692	http://www.ebi.ac.uk/ena/data/view/AF327692
EMBL	AF327693	http://www.ebi.ac.uk/ena/data/view/AF327693
EMBL	AF327694	http://www.ebi.ac.uk/ena/data/view/AF327694
EMBL	AF327695	http://www.ebi.ac.uk/ena/data/view/AF327695
EMBL	AF327696	http://www.ebi.ac.uk/ena/data/view/AF327696
EMBL	AF327697	http://www.ebi.ac.uk/ena/data/view/AF327697
EMBL	AF327698	http://www.ebi.ac.uk/ena/data/view/AF327698
EMBL	AF327699	http://www.ebi.ac.uk/ena/data/view/AF327699
EMBL	AF327700	http://www.ebi.ac.uk/ena/data/view/AF327700
EMBL	AF327701	http://www.ebi.ac.uk/ena/data/view/AF327701
EMBL	AF327702	http://www.ebi.ac.uk/ena/data/view/AF327702
EMBL	AF327703	http://www.ebi.ac.uk/ena/data/view/AF327703
EMBL	AF327704	http://www.ebi.ac.uk/ena/data/view/AF327704
EMBL	AF327705	http://www.ebi.ac.uk/ena/data/view/AF327705
EMBL	AL807752	http://www.ebi.ac.uk/ena/data/view/AL807752
Ensembl	ENST00000341511	http://www.ensembl.org/id/ENST00000341511
Ensembl	ENST00000371605	http://www.ensembl.org/id/ENST00000371605
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GO_component	GO:0005815	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005815
GO_component	GO:0010008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010008
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016023	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016023
GO_component	GO:0043190	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190
GO_function	GO:0000166	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GO_process	GO:0006357	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006357
GO_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0032383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032383
GO_process	GO:0033344	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033344
GO_process	GO:0033700	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033700
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0042632	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042632
GO_process	GO:0048545	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048545
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005815	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005815
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCA2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCA2
GeneID	20	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20
HGNC	HGNC:32	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:32
HOGENOM	HOG000231547	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231547&db=HOGENOM6
HOVERGEN	HBG050436	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050436&db=HOVERGEN
HPA	HPA042886	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042886
InParanoid	Q9BZC7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9BZC7
IntAct	Q9BZC7	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9BZC7*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR026082	http://www.ebi.ac.uk/interpro/entry/IPR026082
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
InterPro	IPR030366	http://www.ebi.ac.uk/interpro/entry/IPR030366
Jabion	20	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=20
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:20	http://www.genome.jp/dbget-bin/www_bget?hsa:20
KEGG_Orthology	KO:K05642	http://www.genome.jp/dbget-bin/www_bget?KO:K05642
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
KEGG_Pathway	ko04142	http://www.genome.jp/kegg-bin/show_pathway?ko04142
MIM	600047	http://www.ncbi.nlm.nih.gov/omim/600047
PANTHER	PTHR19229	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19229
PANTHER	PTHR19229:SF116	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19229:SF116
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PSORT	swissprot:ABCA2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCA2_HUMAN
PSORT-B	swissprot:ABCA2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCA2_HUMAN
PSORT2	swissprot:ABCA2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCA2_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
PharmGKB	PA24377	http://www.pharmgkb.org/do/serve?objId=PA24377&objCls=Gene
Phobius	swissprot:ABCA2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCA2_HUMAN
PhylomeDB	Q9BZC7	http://phylomedb.org/?seqid=Q9BZC7
ProteinModelPortal	Q9BZC7	http://www.proteinmodelportal.org/query/uniprot/Q9BZC7
PubMed	10470851	http://www.ncbi.nlm.nih.gov/pubmed/10470851
PubMed	11178988	http://www.ncbi.nlm.nih.gov/pubmed/11178988
PubMed	11309290	http://www.ncbi.nlm.nih.gov/pubmed/11309290
PubMed	12168954	http://www.ncbi.nlm.nih.gov/pubmed/12168954
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
Reactome	R-HSA-1369062	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1369062
RefSeq	NP_001597	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001597
RefSeq	NP_997698	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_997698
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
STRING	9606.ENSP00000344155	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000344155&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TCDB	3.A.1.211	http://www.tcdb.org/search/result.php?tc=3.A.1.211
UCSC	uc011mem	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc011mem&org=rat
UniGene	Hs.421202	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.421202
UniProtKB	ABCA2_HUMAN	http://www.uniprot.org/uniprot/ABCA2_HUMAN
UniProtKB-AC	Q9BZC7	http://www.uniprot.org/uniprot/Q9BZC7
charge	swissprot:ABCA2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCA2_HUMAN
eggNOG	COG1131	http://eggnogapi.embl.de/nog_data/html/tree/COG1131
eggNOG	KOG0059	http://eggnogapi.embl.de/nog_data/html/tree/KOG0059
epestfind	swissprot:ABCA2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCA2_HUMAN
garnier	swissprot:ABCA2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCA2_HUMAN
helixturnhelix	swissprot:ABCA2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCA2_HUMAN
hmoment	swissprot:ABCA2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCA2_HUMAN
iep	swissprot:ABCA2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCA2_HUMAN
inforesidue	swissprot:ABCA2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCA2_HUMAN
neXtProt	NX_Q9BZC7	http://www.nextprot.org/db/entry/NX_Q9BZC7
octanol	swissprot:ABCA2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCA2_HUMAN
pepcoil	swissprot:ABCA2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCA2_HUMAN
pepdigest	swissprot:ABCA2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCA2_HUMAN
pepinfo	swissprot:ABCA2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCA2_HUMAN
pepnet	swissprot:ABCA2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCA2_HUMAN
pepstats	swissprot:ABCA2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCA2_HUMAN
pepwheel	swissprot:ABCA2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCA2_HUMAN
pepwindow	swissprot:ABCA2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCA2_HUMAN
sigcleave	swissprot:ABCA2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCA2_HUMAN
## Database	ID	URL or Descriptions
# AltName	TM109_HUMAN	Mitsugumin-23
# BioGrid	122524	17
# ChiTaRS	TMEM109	human
# Ensembl	ENST00000227525	ENSP00000227525; ENSG00000110108
# Ensembl	ENST00000536171	ENSP00000443990; ENSG00000110108
# FUNCTION	TM109_HUMAN	May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death (PubMed 23542032). Can form voltage-gated calcium and potassium channels in vitro (By similarity). {ECO 0000250|UniProtKB O77751, ECO 0000269|PubMed 23542032}. 
# GO_component	GO:0005640	nuclear outer membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0033017	sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005244	voltage-gated ion channel activity; IEA:UniProtKB-KW.
# GO_process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IEA:Ensembl.
# GO_process	GO:0060548	negative regulation of cell death; IMP:MGI.
# GO_process	GO:0071480	cellular response to gamma radiation; IMP:MGI.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q9BVC6	HS
# HGNC	HGNC:28771	TMEM109
# IntAct	Q9BVC6	24
# Organism	TM109_HUMAN	Homo sapiens (Human)
# Proteomes	UP000005640	Chromosome 11
# RecName	TM109_HUMAN	Transmembrane protein 109
# RefSeq	NP_076997	NM_024092.2
# SUBCELLULAR LOCATION	TM109_HUMAN	Nucleus outer membrane {ECO 0000250|UniProtKB O77751}; Multi-pass membrane protein {ECO 0000250|UniProtKB O77751}. Endoplasmic reticulum membrane {ECO 0000250|UniProtKB O77751}; Multi-pass membrane protein {ECO 0000250|UniProtKB O77751}. Sarcoplasmic reticulum membrane {ECO 0000250|UniProtKB O77751}; Multi-pass membrane protein {ECO 0000250|UniProtKB O77751}.
# SUBUNIT	TM109_HUMAN	Homooligomer (By similarity). Interacts with CRYAB (PubMed 23542032). {ECO 0000250|UniProtKB O77751, ECO 0000269|PubMed 23542032}. 
# TCDB	1.A.74.1	the mitsugumin 23 (mg23) family
# UCSC	uc001nqg	human
# eggNOG	ENOG410IIBB	Eukaryota
# eggNOG	ENOG410XXDM	LUCA
BLAST	swissprot:TM109_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TM109_HUMAN
BioCyc	ZFISH:ENSG00000110108-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000110108-MONOMER
COXPRESdb	79073	http://coxpresdb.jp/data/gene/79073.shtml
CleanEx	HS_TMEM109	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TMEM109
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.febslet.2013.03.024	http://dx.doi.org/10.1016/j.febslet.2013.03.024
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	BC001309	http://www.ebi.ac.uk/ena/data/view/BC001309
Ensembl	ENST00000227525	http://www.ensembl.org/id/ENST00000227525
Ensembl	ENST00000536171	http://www.ensembl.org/id/ENST00000536171
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005640	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005640
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0033017	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033017
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005244
GO_process	GO:0042771	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042771
GO_process	GO:0060548	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060548
GO_process	GO:0071480	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071480
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	TMEM109	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TMEM109
GeneID	79073	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79073
GeneTree	ENSGT00390000015704	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000015704
HGNC	HGNC:28771	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:28771
HOGENOM	HOG000126892	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126892&db=HOGENOM6
HOVERGEN	HBG083664	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG083664&db=HOVERGEN
HPA	HPA011785	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA011785
InParanoid	Q9BVC6	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9BVC6
IntAct	Q9BVC6	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9BVC6*
Jabion	79073	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=79073
KEGG_Gene	hsa:79073	http://www.genome.jp/dbget-bin/www_bget?hsa:79073
MINT	MINT-5003515	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5003515
OMA	PGQVQTF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PGQVQTF
OrthoDB	EOG091G0S01	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0S01
PSORT	swissprot:TM109_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TM109_HUMAN
PSORT-B	swissprot:TM109_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TM109_HUMAN
PSORT2	swissprot:TM109_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TM109_HUMAN
PharmGKB	PA142670760	http://www.pharmgkb.org/do/serve?objId=PA142670760&objCls=Gene
Phobius	swissprot:TM109_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TM109_HUMAN
PhylomeDB	Q9BVC6	http://phylomedb.org/?seqid=Q9BVC6
ProteinModelPortal	Q9BVC6	http://www.proteinmodelportal.org/query/uniprot/Q9BVC6
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23542032	http://www.ncbi.nlm.nih.gov/pubmed/23542032
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
RefSeq	NP_076997	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_076997
SMR	Q9BVC6	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9BVC6
STRING	9606.ENSP00000227525	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000227525&targetmode=cogs
TCDB	1.A.74.1	http://www.tcdb.org/search/result.php?tc=1.A.74.1
UCSC	uc001nqg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001nqg&org=rat
UniGene	Hs.13662	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.13662
UniProtKB	TM109_HUMAN	http://www.uniprot.org/uniprot/TM109_HUMAN
UniProtKB-AC	Q9BVC6	http://www.uniprot.org/uniprot/Q9BVC6
charge	swissprot:TM109_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TM109_HUMAN
eggNOG	ENOG410IIBB	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IIBB
eggNOG	ENOG410XXDM	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XXDM
epestfind	swissprot:TM109_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TM109_HUMAN
garnier	swissprot:TM109_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TM109_HUMAN
helixturnhelix	swissprot:TM109_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TM109_HUMAN
hmoment	swissprot:TM109_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TM109_HUMAN
iep	swissprot:TM109_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TM109_HUMAN
inforesidue	swissprot:TM109_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TM109_HUMAN
neXtProt	NX_Q9BVC6	http://www.nextprot.org/db/entry/NX_Q9BVC6
octanol	swissprot:TM109_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TM109_HUMAN
pepcoil	swissprot:TM109_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TM109_HUMAN
pepdigest	swissprot:TM109_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TM109_HUMAN
pepinfo	swissprot:TM109_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TM109_HUMAN
pepnet	swissprot:TM109_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TM109_HUMAN
pepstats	swissprot:TM109_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TM109_HUMAN
pepwheel	swissprot:TM109_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TM109_HUMAN
pepwindow	swissprot:TM109_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TM109_HUMAN
sigcleave	swissprot:TM109_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TM109_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CNGA1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P29973-1; Sequence=Displayed; Name=2; IsoId=P29973-2; Sequence=VSP_047170; Note=No experimental confirmation available.; 
# AltName	CNGA1_HUMAN	Cyclic nucleotide-gated cation channel 1
# AltName	CNGA1_HUMAN	Cyclic nucleotide-gated channel alpha-1
# AltName	CNGA1_HUMAN	Cyclic nucleotide-gated channel, photoreceptor
# AltName	CNGA1_HUMAN	Rod photoreceptor cGMP-gated channel subunit alpha
# CAUTION	It is uncertain whether Met-1 or Met-5 is the initiator. {ECO	0000305}. 
# CCDS	CCDS43226	-. [P29973-1]
# CCDS	CCDS47050	-. [P29973-2]
# DISEASE	CNGA1_HUMAN	Retinitis pigmentosa 49 (RP49) [MIM 613756]  A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. {ECO 0000269|PubMed 15570217, ECO 0000269|PubMed 7479749}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	CNGA1_HUMAN	The C-terminal coiled-coil domain mediates homotrimerization of CNGA subunits. {ECO 0000250}. 
# Ensembl	ENST00000358519	ENSP00000351320; ENSG00000198515. [P29973-1]
# Ensembl	ENST00000402813	ENSP00000384264; ENSG00000198515. [P29973-2]
# Ensembl	ENST00000420489	ENSP00000389881; ENSG00000198515. [P29973-1]
# Ensembl	ENST00000514170	ENSP00000426862; ENSG00000198515. [P29973-1]
# Ensembl	ENST00000544810	ENSP00000443401; ENSG00000198515. [P29973-2]
# ExpressionAtlas	P29973	baseline and differential
# FUNCTION	CNGA1_HUMAN	Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0042622	photoreceptor outer segment membrane; IEA:Ensembl.
# GO_function	GO:0005222	intracellular cAMP activated cation channel activity; IBA:GO_Central.
# GO_function	GO:0005223	intracellular cGMP activated cation channel activity; IBA:GO_Central.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IBA:GO_Central.
# GO_function	GO:0030553	cGMP binding; IBA:GO_Central.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007601	visual perception; TAS:ProtInc.
# GO_process	GO:0016056	rhodopsin mediated signaling pathway; TAS:Reactome.
# GO_process	GO:0022400	regulation of rhodopsin mediated signaling pathway; TAS:Reactome.
# GO_process	GO:0042391	regulation of membrane potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# Gene3D	2.60.120.10	-; 1.
# Genevisible	P29973	HS
# HGNC	HGNC:2148	CNGA1
# INTERACTION	CNGA1_HUMAN	Q5ICW4 GRB14 (xeno); NbExp=4; IntAct=EBI-8417095, EBI-7639273; Q9JLM9 Grb14 (xeno); NbExp=2; IntAct=EBI-8417095, EBI-8347358; 
# IntAct	P29973	2
# InterPro	IPR000595	cNMP-bd_dom
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR014710	RmlC-like_jellyroll
# InterPro	IPR018488	cNMP-bd_CS
# InterPro	IPR018490	cNMP-bd-like
# InterPro	IPR032406	CLZ_dom
# InterPro	IPR032945	CNGA1
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00527	[Inherited metabolic disease; Nervous system disease; Eye disease] Retinitis pigmentosa (RP)
# KEGG_Pathway	ko04744	Phototransduction
# MIM	123825	gene
# MIM	613756	phenotype
# Organism	CNGA1_HUMAN	Homo sapiens (Human)
# Orphanet	791	Retinitis pigmentosa
# PANTHER	PTHR10217:SF387	PTHR10217:SF387
# PIR	A42161	A42161
# PROSITE	PS00888	CNMP_BINDING_1
# PROSITE	PS00889	CNMP_BINDING_2
# PROSITE	PS50042	CNMP_BINDING_3
# Pfam	PF00027	cNMP_binding
# Pfam	PF00520	Ion_trans
# Pfam	PF16526	CLZ
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-2485179	Activation of the phototransduction cascade
# Reactome	R-HSA-2514859	Inactivation, recovery and regulation of the phototransduction cascade
# RecName	CNGA1_HUMAN	cGMP-gated cation channel alpha-1
# RefSeq	NP_000078	NM_000087.3. [P29973-1]
# RefSeq	NP_001136036	NM_001142564.1. [P29973-2]
# RefSeq	XP_011511925	XM_011513623.2. [P29973-1]
# RefSeq	XP_016863201	XM_017007712.1. [P29973-1]
# SEQUENCE CAUTION	Sequence=AAB22778.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 cyclic nucleotide-binding domain. {ECO:0000255|PROSITE-ProRule	PRU00060}. 
# SMART	SM00100	cNMP
# SUBCELLULAR LOCATION	CNGA1_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Tetramer formed of three CNGA1 and one CNGB1 modulatory subunits. {ECO	0000250}. 
# SUPFAM	SSF51206	SSF51206
# TCDB	1.A.1.5	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	CNGA1_HUMAN	Rod cells in the retina. 
# UCSC	uc003gxt	human. [P29973-1]
# WEB RESOURCE	CNGA1_HUMAN	Name=Mutations of the CNGA1 gene; Note=Retina International's Scientific Newsletter; URL="http //www.retina-international.org/files/sci-news/cnga1mut.htm";
# eggNOG	ENOG410YWWI	LUCA
# eggNOG	KOG0500	Eukaryota
BLAST	swissprot:CNGA1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CNGA1_HUMAN
BioCyc	ZFISH:G66-33190-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33190-MONOMER
COXPRESdb	1259	http://coxpresdb.jp/data/gene/1259.shtml
CleanEx	HS_CNGA1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CNGA1
DOI	10.1016/0028-3908(94)90027-2	http://dx.doi.org/10.1016/0028-3908(94)90027-2
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.92.22.10177	http://dx.doi.org/10.1073/pnas.92.22.10177
EMBL	AC096749	http://www.ebi.ac.uk/ena/data/view/AC096749
EMBL	AC107068	http://www.ebi.ac.uk/ena/data/view/AC107068
EMBL	AK292021	http://www.ebi.ac.uk/ena/data/view/AK292021
EMBL	CH471069	http://www.ebi.ac.uk/ena/data/view/CH471069
EMBL	M84741	http://www.ebi.ac.uk/ena/data/view/M84741
EMBL	S42457	http://www.ebi.ac.uk/ena/data/view/S42457
EMBL	S76062	http://www.ebi.ac.uk/ena/data/view/S76062
Ensembl	ENST00000358519	http://www.ensembl.org/id/ENST00000358519
Ensembl	ENST00000402813	http://www.ensembl.org/id/ENST00000402813
Ensembl	ENST00000420489	http://www.ensembl.org/id/ENST00000420489
Ensembl	ENST00000514170	http://www.ensembl.org/id/ENST00000514170
Ensembl	ENST00000544810	http://www.ensembl.org/id/ENST00000544810
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0042622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042622
GO_function	GO:0005222	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005222
GO_function	GO:0005223	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005223
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0030553	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030553
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007601	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007601
GO_process	GO:0016056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016056
GO_process	GO:0022400	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022400
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
Gene3D	2.60.120.10	http://www.cathdb.info/version/latest/superfamily/2.60.120.10
GeneCards	CNGA1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CNGA1
GeneID	1259	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1259
GeneTree	ENSGT00760000118772	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118772
H-InvDB	HIX0031530	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0031530
H-InvDB	HIX0031590	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0031590
HGNC	HGNC:2148	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2148
HOGENOM	HOG000007898	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007898&db=HOGENOM6
HOVERGEN	HBG000281	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000281&db=HOVERGEN
HPA	HPA059734	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA059734
InParanoid	P29973	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P29973
IntAct	P29973	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P29973*
InterPro	IPR000595	http://www.ebi.ac.uk/interpro/entry/IPR000595
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR014710	http://www.ebi.ac.uk/interpro/entry/IPR014710
InterPro	IPR018488	http://www.ebi.ac.uk/interpro/entry/IPR018488
InterPro	IPR018490	http://www.ebi.ac.uk/interpro/entry/IPR018490
InterPro	IPR032406	http://www.ebi.ac.uk/interpro/entry/IPR032406
InterPro	IPR032945	http://www.ebi.ac.uk/interpro/entry/IPR032945
Jabion	1259	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1259
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00527	http://www.genome.jp/dbget-bin/www_bget?H00527
KEGG_Gene	hsa:1259	http://www.genome.jp/dbget-bin/www_bget?hsa:1259
KEGG_Orthology	KO:K04948	http://www.genome.jp/dbget-bin/www_bget?KO:K04948
KEGG_Pathway	ko04744	http://www.genome.jp/kegg-bin/show_pathway?ko04744
MIM	123825	http://www.ncbi.nlm.nih.gov/omim/123825
MIM	613756	http://www.ncbi.nlm.nih.gov/omim/613756
MINT	MINT-7004260	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-7004260
OMA	YLEYWLI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YLEYWLI
Orphanet	791	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=791
OrthoDB	EOG091G03EW	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G03EW
PANTHER	PTHR10217:SF387	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10217:SF387
PROSITE	PS00888	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00888
PROSITE	PS00889	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00889
PROSITE	PS50042	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50042
PSORT	swissprot:CNGA1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CNGA1_HUMAN
PSORT-B	swissprot:CNGA1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CNGA1_HUMAN
PSORT2	swissprot:CNGA1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CNGA1_HUMAN
Pfam	PF00027	http://pfam.xfam.org/family/PF00027
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF16526	http://pfam.xfam.org/family/PF16526
PharmGKB	PA26658	http://www.pharmgkb.org/do/serve?objId=PA26658&objCls=Gene
Phobius	swissprot:CNGA1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CNGA1_HUMAN
PhylomeDB	P29973	http://phylomedb.org/?seqid=P29973
ProteinModelPortal	P29973	http://www.proteinmodelportal.org/query/uniprot/P29973
PubMed	1372902	http://www.ncbi.nlm.nih.gov/pubmed/1372902
PubMed	1379636	http://www.ncbi.nlm.nih.gov/pubmed/1379636
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15570217	http://www.ncbi.nlm.nih.gov/pubmed/15570217
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	7479749	http://www.ncbi.nlm.nih.gov/pubmed/7479749
PubMed	7532814	http://www.ncbi.nlm.nih.gov/pubmed/7532814
Reactome	R-HSA-2485179	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2485179
Reactome	R-HSA-2514859	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2514859
RefSeq	NP_000078	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000078
RefSeq	NP_001136036	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001136036
RefSeq	XP_011511925	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011511925
RefSeq	XP_016863201	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016863201
SMART	SM00100	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00100
SMR	P29973	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P29973
STRING	9606.ENSP00000384264	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000384264&targetmode=cogs
SUPFAM	SSF51206	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51206
TCDB	1.A.1.5	http://www.tcdb.org/search/result.php?tc=1.A.1.5
UCSC	uc003gxt	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003gxt&org=rat
UniGene	Hs.1323	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.1323
UniProtKB	CNGA1_HUMAN	http://www.uniprot.org/uniprot/CNGA1_HUMAN
UniProtKB-AC	P29973	http://www.uniprot.org/uniprot/P29973
charge	swissprot:CNGA1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CNGA1_HUMAN
eggNOG	ENOG410YWWI	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YWWI
eggNOG	KOG0500	http://eggnogapi.embl.de/nog_data/html/tree/KOG0500
epestfind	swissprot:CNGA1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CNGA1_HUMAN
garnier	swissprot:CNGA1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CNGA1_HUMAN
helixturnhelix	swissprot:CNGA1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CNGA1_HUMAN
hmoment	swissprot:CNGA1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CNGA1_HUMAN
iep	swissprot:CNGA1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CNGA1_HUMAN
inforesidue	swissprot:CNGA1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CNGA1_HUMAN
neXtProt	NX_P29973	http://www.nextprot.org/db/entry/NX_P29973
octanol	swissprot:CNGA1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CNGA1_HUMAN
pepcoil	swissprot:CNGA1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CNGA1_HUMAN
pepdigest	swissprot:CNGA1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CNGA1_HUMAN
pepinfo	swissprot:CNGA1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CNGA1_HUMAN
pepnet	swissprot:CNGA1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CNGA1_HUMAN
pepstats	swissprot:CNGA1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CNGA1_HUMAN
pepwheel	swissprot:CNGA1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CNGA1_HUMAN
pepwindow	swissprot:CNGA1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CNGA1_HUMAN
sigcleave	swissprot:CNGA1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CNGA1_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	117924	62
# ChiTaRS	RANBP6	human
# Ensembl	ENST00000259569	ENSP00000259569; ENSG00000137040
# ExpressionAtlas	O60518	baseline and differential
# FUNCTION	RNBP6_HUMAN	May function in nuclear protein import as nuclear transport receptor. 
# GO_component	GO:0005737	cytoplasm; IBA:GO_Central.
# GO_component	GO:0031965	nuclear membrane; IBA:GO_Central.
# GO_component	GO:0034399	nuclear periphery; IBA:GO_Central.
# GO_function	GO:0008139	nuclear localization sequence binding; IBA:GO_Central.
# GO_function	GO:0008565	protein transporter activity; IBA:GO_Central.
# GO_process	GO:0000059	protein import into nucleus, docking; IBA:GO_Central.
# GO_process	GO:0000060	protein import into nucleus, translocation; IBA:GO_Central.
# GO_process	GO:0006607	NLS-bearing protein import into nucleus; IBA:GO_Central.
# GO_process	GO:0006610	ribosomal protein import into nucleus; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# Gene3D	1.25.10.10	-; 3.
# Genevisible	O60518	HS
# HGNC	HGNC:9851	RANBP6
# INTERACTION	RNBP6_HUMAN	Q76353 - (xeno); NbExp=2; IntAct=EBI-1055771, EBI-6248077; 
# IntAct	O60518	6
# InterPro	IPR000357	HEAT
# InterPro	IPR011989	ARM-like
# InterPro	IPR016024	ARM-type_fold
# Organism	RNBP6_HUMAN	Homo sapiens (Human)
# Pfam	PF02985	HEAT
# Proteomes	UP000005640	Chromosome 9
# RecName	RNBP6_HUMAN	Ran-binding protein 6
# RefSeq	NP_001230131	NM_001243202.1
# RefSeq	NP_001230132	NM_001243203.1
# RefSeq	NP_036548	NM_012416.3
# SEQUENCE CAUTION	Sequence=CAD97647.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the importin beta family. {ECO	0000305}. 
# SIMILARITY	Contains 7 HEAT repeats. {ECO	0000305}. 
# SUBCELLULAR LOCATION	RNBP6_HUMAN	Cytoplasm {ECO 0000250}. Nucleus {ECO 0000250}. 
# SUPFAM	SSF48371	SSF48371; 3
# UCSC	uc003zjr	human
# eggNOG	ENOG410XQAJ	LUCA
# eggNOG	KOG2171	Eukaryota
BLAST	swissprot:RNBP6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:RNBP6_HUMAN
BioCyc	ZFISH:ENSG00000137040-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000137040-MONOMER
COXPRESdb	26953	http://coxpresdb.jp/data/gene/26953.shtml
CleanEx	HS_RANBP6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_RANBP6
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AF039023	http://www.ebi.ac.uk/ena/data/view/AF039023
EMBL	AL162384	http://www.ebi.ac.uk/ena/data/view/AL162384
EMBL	BC012805	http://www.ebi.ac.uk/ena/data/view/BC012805
EMBL	BC098406	http://www.ebi.ac.uk/ena/data/view/BC098406
EMBL	BX537405	http://www.ebi.ac.uk/ena/data/view/BX537405
Ensembl	ENST00000259569	http://www.ensembl.org/id/ENST00000259569
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0031965	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031965
GO_component	GO:0034399	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034399
GO_function	GO:0008139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008139
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0000059	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000059
GO_process	GO:0000060	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000060
GO_process	GO:0006607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006607
GO_process	GO:0006610	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006610
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
GeneCards	RANBP6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=RANBP6
GeneID	26953	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26953
GeneTree	ENSGT00550000074773	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074773
H-InvDB	HIX0007906	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0007906
HGNC	HGNC:9851	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:9851
HOGENOM	HOG000209725	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000209725&db=HOGENOM6
HOVERGEN	HBG006156	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006156&db=HOVERGEN
HPA	HPA043748	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA043748
HPA	HPA052684	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA052684
InParanoid	O60518	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O60518
IntAct	O60518	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O60518*
InterPro	IPR000357	http://www.ebi.ac.uk/interpro/entry/IPR000357
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
Jabion	26953	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=26953
KEGG_Gene	hsa:26953	http://www.genome.jp/dbget-bin/www_bget?hsa:26953
MINT	MINT-1196413	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1196413
OMA	FGTQERH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FGTQERH
OrthoDB	EOG091G011X	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G011X
PSORT	swissprot:RNBP6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:RNBP6_HUMAN
PSORT-B	swissprot:RNBP6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:RNBP6_HUMAN
PSORT2	swissprot:RNBP6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:RNBP6_HUMAN
Pfam	PF02985	http://pfam.xfam.org/family/PF02985
PharmGKB	PA34212	http://www.pharmgkb.org/do/serve?objId=PA34212&objCls=Gene
Phobius	swissprot:RNBP6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:RNBP6_HUMAN
PhylomeDB	O60518	http://phylomedb.org/?seqid=O60518
ProteinModelPortal	O60518	http://www.proteinmodelportal.org/query/uniprot/O60518
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
RefSeq	NP_001230131	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001230131
RefSeq	NP_001230132	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001230132
RefSeq	NP_036548	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_036548
SMR	O60518	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O60518
STRING	9606.ENSP00000259569	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000259569&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
UCSC	uc003zjr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003zjr&org=rat
UniGene	Hs.167496	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.167496
UniGene	Hs.732683	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.732683
UniProtKB	RNBP6_HUMAN	http://www.uniprot.org/uniprot/RNBP6_HUMAN
UniProtKB-AC	O60518	http://www.uniprot.org/uniprot/O60518
charge	swissprot:RNBP6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:RNBP6_HUMAN
eggNOG	ENOG410XQAJ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQAJ
eggNOG	KOG2171	http://eggnogapi.embl.de/nog_data/html/tree/KOG2171
epestfind	swissprot:RNBP6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:RNBP6_HUMAN
garnier	swissprot:RNBP6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:RNBP6_HUMAN
helixturnhelix	swissprot:RNBP6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:RNBP6_HUMAN
hmoment	swissprot:RNBP6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:RNBP6_HUMAN
iep	swissprot:RNBP6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:RNBP6_HUMAN
inforesidue	swissprot:RNBP6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:RNBP6_HUMAN
neXtProt	NX_O60518	http://www.nextprot.org/db/entry/NX_O60518
octanol	swissprot:RNBP6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:RNBP6_HUMAN
pepcoil	swissprot:RNBP6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:RNBP6_HUMAN
pepdigest	swissprot:RNBP6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:RNBP6_HUMAN
pepinfo	swissprot:RNBP6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:RNBP6_HUMAN
pepnet	swissprot:RNBP6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:RNBP6_HUMAN
pepstats	swissprot:RNBP6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:RNBP6_HUMAN
pepwheel	swissprot:RNBP6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:RNBP6_HUMAN
pepwindow	swissprot:RNBP6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:RNBP6_HUMAN
sigcleave	swissprot:RNBP6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:RNBP6_HUMAN
## Database	ID	URL or Descriptions
# AltName	HCN1_HUMAN	Brain cyclic nucleotide-gated channel 1
# BioGrid	131543	5
# ChiTaRS	HCN1	human
# DISEASE	HCN1_HUMAN	Epileptic encephalopathy, early infantile, 24 (EIEE24) [MIM 615871]  A disease characterized by early-onset seizures, intellectual disability of varying degrees, and behavioral disturbances or autistic features in most individuals. {ECO 0000269|PubMed 24747641}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	HCN1_HUMAN	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. 
# ENZYME REGULATION	Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. cAMP binding promotes tetramerization and formation of an active channel. Compared to other family members, cAMP has less stimulatory effect on HCN1 because part of the molecules already contain bound cAMP and form homotetramers when cAMP levels are low. Inhibited by Cs(1+), zatebradine, capsazepine and ZD7288. {ECO:0000269|PubMed	15351778}. 
# Ensembl	ENST00000303230	ENSP00000307342; ENSG00000164588
# ExpressionAtlas	O60741	baseline and differential
# FUNCTION	HCN1_HUMAN	Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli. {ECO 0000269|PubMed 15351778}. 
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; ISS:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0030424	axon; IEA:Ensembl.
# GO_component	GO:0030425	dendrite; IEA:Ensembl.
# GO_function	GO:0005222	intracellular cAMP activated cation channel activity; ISS:UniProtKB.
# GO_function	GO:0005248	voltage-gated sodium channel activity; IMP:UniProtKB.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IMP:UniProtKB.
# GO_function	GO:0005267	potassium channel activity; NAS:UniProtKB.
# GO_function	GO:0030552	cAMP binding; ISS:UniProtKB.
# GO_process	GO:0006813	potassium ion transport; NAS:UniProtKB.
# GO_process	GO:0035725	sodium ion transmembrane transport; IMP:UniProtKB.
# GO_process	GO:0042391	regulation of membrane potential; IMP:UniProtKB.
# GO_process	GO:0045176	apical protein localization; IEA:Ensembl.
# GO_process	GO:0046549	retinal cone cell development; IEA:Ensembl.
# GO_process	GO:0071320	cellular response to cAMP; IDA:UniProtKB.
# GO_process	GO:0071805	potassium ion transmembrane transport; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.120.10	-; 1.
# Genevisible	O60741	HS
# HGNC	HGNC:4845	HCN1
# InterPro	IPR000595	cNMP-bd_dom
# InterPro	IPR003938	K_chnl_volt-dep_EAG/ELK/ERG
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR013621	Ion_trans_N
# InterPro	IPR014710	RmlC-like_jellyroll
# InterPro	IPR018488	cNMP-bd_CS
# InterPro	IPR018490	cNMP-bd-like
# InterPro	IPR030169	K/Na_HCN1
# KEGG_Brite	ko04040	Ion channels
# MIM	602780	gene
# MIM	615871	phenotype
# Organism	HCN1_HUMAN	Homo sapiens (Human)
# Orphanet	1934	Early infantile epileptic encephalopathy
# PANTHER	PTHR10217:SF373	PTHR10217:SF373
# PRINTS	PR01463	EAGCHANLFMLY
# PROSITE	PS00888	CNMP_BINDING_1
# PROSITE	PS50042	CNMP_BINDING_3
# Pfam	PF00027	cNMP_binding
# Pfam	PF00520	Ion_trans
# Pfam	PF08412	Ion_trans_N
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-1296061	HCN channels
# RecName	HCN1_HUMAN	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
# RefSeq	NP_066550	NM_021072.3
# SEQUENCE CAUTION	Sequence=AAC39759.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the potassium channel HCN family. {ECO	0000305}. 
# SIMILARITY	Contains 1 cyclic nucleotide-binding domain. {ECO:0000255|PROSITE-ProRule	PRU00060}. 
# SMART	SM00100	cNMP
# SUBCELLULAR LOCATION	HCN1_HUMAN	Cell membrane {ECO 0000269|PubMed 15351778}; Multi-pass membrane protein {ECO 0000269|PubMed 15351778}. 
# SUBUNIT	Homotetramer. Heterotetramer with HCN2. The potassium channel is composed of a homo- or heterotetrameric complex of pore-forming subunits. Interacts with KCNE2. Interacts with the SH3 domain of CSK (By similarity). {ECO	0000250}. 
# SUPFAM	SSF51206	SSF51206
# TISSUE SPECIFICITY	Detected in brain, in particular in amygdala and hippocampus, while expression in caudate nucleus, corpus callosum, substantia nigra, subthalamic nucleus and thalamus is very low or not detectable. Detected at very low levels in muscle and pancreas. {ECO:0000269|PubMed	9630217}. 
# UCSC	uc003jok	human
# eggNOG	ENOG410XPSE	LUCA
# eggNOG	KOG0498	Eukaryota
BLAST	swissprot:HCN1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:HCN1_HUMAN
BioCyc	ZFISH:ENSG00000164588-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000164588-MONOMER
COXPRESdb	348980	http://coxpresdb.jp/data/gene/348980.shtml
CleanEx	HS_HCN1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_HCN1
DIP	DIP-62038N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-62038N
DOI	10.1016/S0092-8674(00)81434-8	http://dx.doi.org/10.1016/S0092-8674(00)81434-8
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1038/ng.2952	http://dx.doi.org/10.1038/ng.2952
DOI	10.1038/sj.bjp.0705945	http://dx.doi.org/10.1038/sj.bjp.0705945
EMBL	AC099514	http://www.ebi.ac.uk/ena/data/view/AC099514
EMBL	AC114975	http://www.ebi.ac.uk/ena/data/view/AC114975
EMBL	AC117529	http://www.ebi.ac.uk/ena/data/view/AC117529
EMBL	AC138520	http://www.ebi.ac.uk/ena/data/view/AC138520
EMBL	AF064876	http://www.ebi.ac.uk/ena/data/view/AF064876
Ensembl	ENST00000303230	http://www.ensembl.org/id/ENST00000303230
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030424	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030424
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_function	GO:0005222	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005222
GO_function	GO:0005248	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005248
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_function	GO:0030552	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030552
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0035725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035725
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0045176	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045176
GO_process	GO:0046549	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046549
GO_process	GO:0071320	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071320
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.120.10	http://www.cathdb.info/version/latest/superfamily/2.60.120.10
GeneCards	HCN1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=HCN1
GeneID	348980	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=348980
GeneTree	ENSGT00760000118772	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118772
H-InvDB	HIX0004850	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0004850
HGNC	HGNC:4845	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4845
HOGENOM	HOG000230717	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230717&db=HOGENOM6
HOVERGEN	HBG039489	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG039489&db=HOVERGEN
HPA	HPA019195	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA019195
InParanoid	O60741	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O60741
InterPro	IPR000595	http://www.ebi.ac.uk/interpro/entry/IPR000595
InterPro	IPR003938	http://www.ebi.ac.uk/interpro/entry/IPR003938
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR013621	http://www.ebi.ac.uk/interpro/entry/IPR013621
InterPro	IPR014710	http://www.ebi.ac.uk/interpro/entry/IPR014710
InterPro	IPR018488	http://www.ebi.ac.uk/interpro/entry/IPR018488
InterPro	IPR018490	http://www.ebi.ac.uk/interpro/entry/IPR018490
InterPro	IPR030169	http://www.ebi.ac.uk/interpro/entry/IPR030169
Jabion	348980	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=348980
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:348980	http://www.genome.jp/dbget-bin/www_bget?hsa:348980
KEGG_Orthology	KO:K04954	http://www.genome.jp/dbget-bin/www_bget?KO:K04954
MIM	602780	http://www.ncbi.nlm.nih.gov/omim/602780
MIM	615871	http://www.ncbi.nlm.nih.gov/omim/615871
OMA	EVHRSTQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EVHRSTQ
Orphanet	1934	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1934
OrthoDB	EOG091G0JQU	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0JQU
PANTHER	PTHR10217:SF373	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10217:SF373
PRINTS	PR01463	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01463
PROSITE	PS00888	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00888
PROSITE	PS50042	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50042
PSORT	swissprot:HCN1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:HCN1_HUMAN
PSORT-B	swissprot:HCN1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:HCN1_HUMAN
PSORT2	swissprot:HCN1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:HCN1_HUMAN
Pfam	PF00027	http://pfam.xfam.org/family/PF00027
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF08412	http://pfam.xfam.org/family/PF08412
PharmGKB	PA77	http://www.pharmgkb.org/do/serve?objId=PA77&objCls=Gene
Phobius	swissprot:HCN1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:HCN1_HUMAN
PhylomeDB	O60741	http://phylomedb.org/?seqid=O60741
ProteinModelPortal	O60741	http://www.proteinmodelportal.org/query/uniprot/O60741
PubMed	15351778	http://www.ncbi.nlm.nih.gov/pubmed/15351778
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	24747641	http://www.ncbi.nlm.nih.gov/pubmed/24747641
PubMed	9630217	http://www.ncbi.nlm.nih.gov/pubmed/9630217
Reactome	R-HSA-1296061	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296061
RefSeq	NP_066550	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_066550
SMART	SM00100	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00100
SMR	O60741	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O60741
STRING	9606.ENSP00000307342	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000307342&targetmode=cogs
SUPFAM	SSF51206	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51206
UCSC	uc003jok	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003jok&org=rat
UniGene	Hs.353176	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.353176
UniProtKB	HCN1_HUMAN	http://www.uniprot.org/uniprot/HCN1_HUMAN
UniProtKB-AC	O60741	http://www.uniprot.org/uniprot/O60741
charge	swissprot:HCN1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:HCN1_HUMAN
eggNOG	ENOG410XPSE	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPSE
eggNOG	KOG0498	http://eggnogapi.embl.de/nog_data/html/tree/KOG0498
epestfind	swissprot:HCN1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:HCN1_HUMAN
garnier	swissprot:HCN1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:HCN1_HUMAN
helixturnhelix	swissprot:HCN1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:HCN1_HUMAN
hmoment	swissprot:HCN1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:HCN1_HUMAN
iep	swissprot:HCN1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:HCN1_HUMAN
inforesidue	swissprot:HCN1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:HCN1_HUMAN
neXtProt	NX_O60741	http://www.nextprot.org/db/entry/NX_O60741
octanol	swissprot:HCN1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:HCN1_HUMAN
pepcoil	swissprot:HCN1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:HCN1_HUMAN
pepdigest	swissprot:HCN1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:HCN1_HUMAN
pepinfo	swissprot:HCN1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:HCN1_HUMAN
pepnet	swissprot:HCN1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:HCN1_HUMAN
pepstats	swissprot:HCN1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:HCN1_HUMAN
pepwheel	swissprot:HCN1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:HCN1_HUMAN
pepwindow	swissprot:HCN1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:HCN1_HUMAN
sigcleave	swissprot:HCN1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:HCN1_HUMAN
## Database	ID	URL or Descriptions
# AltName	SCNNG_HUMAN	Epithelial Na(+) channel subunit gamma
# AltName	SCNNG_HUMAN	Gamma-NaCH
# AltName	SCNNG_HUMAN	Nonvoltage-gated sodium channel 1 subunit gamma
# AltName	SCNNG_HUMAN	SCNEG
# BioGrid	112244	13
# DISEASE	SCNNG_HUMAN	Bronchiectasis with or without elevated sweat chloride 3 (BESC3) [MIM 613071]  A debilitating respiratory disease characterized by chronic, abnormal dilatation of the bronchi and other cystic fibrosis-like symptoms in the absence of known causes of bronchiectasis (cystic fibrosis, autoimmune diseases, ciliary dyskinesia, common variable immunodeficiency, foreign body obstruction). Clinical features include sub-normal lung function, sinopulmonary infections, chronic productive cough, excessive sputum production, and elevated sweat chloride in some cases. {ECO 0000269|PubMed 18507830, ECO 0000269|PubMed 19017867}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCNNG_HUMAN	Liddle syndrome (LIDLS) [MIM 177200]  An autosomal dominant disorder characterized by hypertension, hypokalemic alkalosis, and suppression of plasma renin activity and aldosterone secretion. {ECO 0000269|PubMed 7550319}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00384	Triamterene
# DrugBank	DB00594	Amiloride
# ENZYME REGULATION	Activated by WNK1, WNK2, WNK3 and WNK4. {ECO:0000250|UniProtKB	Q9WU39}. 
# Ensembl	ENST00000300061	ENSP00000300061; ENSG00000166828
# ExpressionAtlas	P51170	baseline and differential
# FUNCTION	SCNNG_HUMAN	Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. {ECO 0000269|PubMed 24124190, ECO 0000303|PubMed 7490094}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0009897	external side of plasma membrane; IEA:Ensembl.
# GO_component	GO:0016324	apical plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0034706	sodium channel complex; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005216	ion channel activity; IMP:CACAO.
# GO_function	GO:0005272	sodium channel activity; TAS:ProtInc.
# GO_function	GO:0015280	ligand-gated sodium channel activity; TAS:ProtInc.
# GO_function	GO:0050699	WW domain binding; IPI:BHF-UCL.
# GO_process	GO:0006814	sodium ion transport; TAS:ProtInc.
# GO_process	GO:0007588	excretion; TAS:ProtInc.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0035725	sodium ion transmembrane transport; IDA:UniProtKB.
# GO_process	GO:0050891	multicellular organismal water homeostasis; IDA:UniProtKB.
# GO_process	GO:0050896	response to stimulus; IEA:UniProtKB-KW.
# GO_process	GO:0050909	sensory perception of taste; IEA:UniProtKB-KW.
# GO_process	GO:0055078	sodium ion homeostasis; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P51170	HS
# HGNC	HGNC:10602	SCNN1G
# INTERACTION	SCNNG_HUMAN	P37088 SCNN1A; NbExp=3; IntAct=EBI-2547354, EBI-7845444; 
# IntAct	P51170	3
# InterPro	IPR001873	Na+channel_ASC
# InterPro	IPR004724	ENaC
# InterPro	IPR020903	Na+channel_ASC_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00242	[Endocrine disease; Urinary system disease] Liddle syndrome
# KEGG_Disease	H00243	[Endocrine disease; Urinary system disease] Pseudohypoaldosteronism type II (Gordon's syndrome)
# KEGG_Disease	H00892	[Respiratory disease] Bronchiectasis with or without elevated sweat chloride
# KEGG_Disease	H01633	[Cardiovascular diseases] Hypertension
# KEGG_Pathway	ko04742	Taste transduction
# KEGG_Pathway	ko04960	Aldosterone-regulated sodium reabsorption
# MIM	177200	phenotype
# MIM	600761	gene
# MIM	613071	phenotype
# Organism	SCNNG_HUMAN	Homo sapiens (Human)
# Orphanet	171876	Generalized pseudohypoaldosteronism type 1
# Orphanet	526	Liddle syndrome
# Orphanet	60033	Idiopathic bronchiectasis
# PANTHER	PTHR11690	PTHR11690; 2
# PIR	I38204	I38204
# PIR	I64847	I64847
# PRINTS	PR01078	AMINACHANNEL
# PROSITE	PS01206	ASC
# PTM	SCNNG_HUMAN	ENaC cleavage by furin, and subsequently by prostasin (PRSS8), leads to a stepwise increase in the open probability of the channel as a result of release of the alpha and gamma subunit inhibitory tracts, respectively. Interaction of ENaC subunit SCNN1B with BPIFA1 protects ENaC against proteolytic activation. {ECO 0000269|PubMed 18650438, ECO 0000269|PubMed 24124190}. 
# PTM	SCNNG_HUMAN	Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation. {ECO 0000250|UniProtKB P37091}. 
# PTM	SCNNG_HUMAN	Ubiquitinated; this targets individual subunits for endocytosis and proteasome-mediated degradation. {ECO 0000250|UniProtKB P37091}. 
# Pfam	PF00858	ASC
# Proteomes	UP000005640	Chromosome 16
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	SCNNG_HUMAN	Amiloride-sensitive sodium channel subunit gamma
# RefSeq	NP_001030	NM_001039.3
# SIMILARITY	Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1G subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	SCNNG_HUMAN	Apical cell membrane {ECO 0000269|PubMed 24124190, ECO 0000303|PubMed 7490094}; Multi- pass membrane protein {ECO 0000250|UniProtKB P37089}. Note=Apical membrane of epithelial cells. {ECO 0000303|PubMed 7490094}. 
# SUBUNIT	SCNNG_HUMAN	Heterotrimer containing an alpha/SCNN1A, a beta/SCNN1B and a gamma/SCNN1G subunit. An additional delta/SCNN1D subunit exists only in some organisms and can replace the alpha/SCNN1A subunit to form an alternative channel with specific properties (PubMed 7762608). Interacts with NEDD4; via the WW domains (PubMed 11244092, PubMed 12167593). Interacts with NEDD4L; via the WW domains (PubMed 11244092). Interacts with WWP1; via the WW domains (PubMed 9169421). Interacts with WWP2; via the WW domains (PubMed 9169421, PubMed 12167593). Interacts with the full length immature form of PCSK9 (pro-PCSK9) (PubMed 22493497). {ECO 0000269|PubMed 11244092, ECO 0000269|PubMed 12167593, ECO 0000269|PubMed 22493497, ECO 0000269|PubMed 24124190, ECO 0000269|PubMed 7490094, ECO 0000269|PubMed 7762608, ECO 0000269|PubMed 9169421}. 
# TCDB	1.A.6.1	the epithelial na(+) channel (enac) family
# TIGRFAMs	TIGR00859	ENaC
# TISSUE SPECIFICITY	Expressed in kidney (at protein level). {ECO:0000269|PubMed	22207244}. 
# UCSC	uc002dlm	human
# eggNOG	ENOG410ZNFK	LUCA
# eggNOG	KOG4294	Eukaryota
BLAST	swissprot:SCNNG_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SCNNG_HUMAN
BioCyc	ZFISH:ENSG00000166828-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000166828-MONOMER
COXPRESdb	6340	http://coxpresdb.jp/data/gene/6340.shtml
DOI	10.1006/geno.1995.1188	http://dx.doi.org/10.1006/geno.1995.1188
DOI	10.1007/s00418-011-0904-1	http://dx.doi.org/10.1007/s00418-011-0904-1
DOI	10.1016/j.gene.2015.12.061	http://dx.doi.org/10.1016/j.gene.2015.12.061
DOI	10.1038/10297	http://dx.doi.org/10.1038/10297
DOI	10.1038/ng0995-76	http://dx.doi.org/10.1038/ng0995-76
DOI	10.1074/jbc.271.42.26062	http://dx.doi.org/10.1074/jbc.271.42.26062
DOI	10.1074/jbc.272.23.14611	http://dx.doi.org/10.1074/jbc.272.23.14611
DOI	10.1074/jbc.C000906200	http://dx.doi.org/10.1074/jbc.C000906200
DOI	10.1074/jbc.M112.363382	http://dx.doi.org/10.1074/jbc.M112.363382
DOI	10.1074/jbc.M803931200	http://dx.doi.org/10.1074/jbc.M803931200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1152/ajplung.00103.2013	http://dx.doi.org/10.1152/ajplung.00103.2013
DOI	10.1152/ajprenal.00080.2002	http://dx.doi.org/10.1152/ajprenal.00080.2002
DOI	10.1186/1465-9921-9-46	http://dx.doi.org/10.1186/1465-9921-9-46
DOI	10.1210/jc.84.7.2434	http://dx.doi.org/10.1210/jc.84.7.2434
DOI	10.1210/jcem.87.7.8674	http://dx.doi.org/10.1210/jcem.87.7.8674
DOI	10.1378/chest.08-2246	http://dx.doi.org/10.1378/chest.08-2246
DrugBank	DB00384	http://www.drugbank.ca/drugs/DB00384
DrugBank	DB00594	http://www.drugbank.ca/drugs/DB00594
EMBL	AF356493	http://www.ebi.ac.uk/ena/data/view/AF356493
EMBL	AF356494	http://www.ebi.ac.uk/ena/data/view/AF356494
EMBL	AF356495	http://www.ebi.ac.uk/ena/data/view/AF356495
EMBL	AF356496	http://www.ebi.ac.uk/ena/data/view/AF356496
EMBL	AF356497	http://www.ebi.ac.uk/ena/data/view/AF356497
EMBL	AF356498	http://www.ebi.ac.uk/ena/data/view/AF356498
EMBL	AF356499	http://www.ebi.ac.uk/ena/data/view/AF356499
EMBL	AF356500	http://www.ebi.ac.uk/ena/data/view/AF356500
EMBL	AF356501	http://www.ebi.ac.uk/ena/data/view/AF356501
EMBL	AF356502	http://www.ebi.ac.uk/ena/data/view/AF356502
EMBL	BC059391	http://www.ebi.ac.uk/ena/data/view/BC059391
EMBL	BC069652	http://www.ebi.ac.uk/ena/data/view/BC069652
EMBL	L36592	http://www.ebi.ac.uk/ena/data/view/L36592
EMBL	U35630	http://www.ebi.ac.uk/ena/data/view/U35630
EMBL	U48936	http://www.ebi.ac.uk/ena/data/view/U48936
EMBL	U53836	http://www.ebi.ac.uk/ena/data/view/U53836
EMBL	U53837	http://www.ebi.ac.uk/ena/data/view/U53837
EMBL	U53841	http://www.ebi.ac.uk/ena/data/view/U53841
EMBL	U53844	http://www.ebi.ac.uk/ena/data/view/U53844
EMBL	U53845	http://www.ebi.ac.uk/ena/data/view/U53845
EMBL	U53846	http://www.ebi.ac.uk/ena/data/view/U53846
EMBL	U53847	http://www.ebi.ac.uk/ena/data/view/U53847
EMBL	U53850	http://www.ebi.ac.uk/ena/data/view/U53850
EMBL	U53852	http://www.ebi.ac.uk/ena/data/view/U53852
EMBL	X87160	http://www.ebi.ac.uk/ena/data/view/X87160
Ensembl	ENST00000300061	http://www.ensembl.org/id/ENST00000300061
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0009897	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009897
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0034706	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034706
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005216	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005216
GO_function	GO:0005272	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005272
GO_function	GO:0015280	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015280
GO_function	GO:0050699	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050699
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0007588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007588
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0035725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035725
GO_process	GO:0050891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050891
GO_process	GO:0050896	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050896
GO_process	GO:0050909	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050909
GO_process	GO:0055078	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055078
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SCNN1G	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SCNN1G
GeneID	6340	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6340
GeneTree	ENSGT00760000119120	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119120
HGNC	HGNC:10602	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10602
HOVERGEN	HBG058435	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG058435&db=HOVERGEN
InParanoid	P51170	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P51170
IntAct	P51170	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P51170*
InterPro	IPR001873	http://www.ebi.ac.uk/interpro/entry/IPR001873
InterPro	IPR004724	http://www.ebi.ac.uk/interpro/entry/IPR004724
InterPro	IPR020903	http://www.ebi.ac.uk/interpro/entry/IPR020903
Jabion	6340	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6340
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00242	http://www.genome.jp/dbget-bin/www_bget?H00242
KEGG_Disease	H00243	http://www.genome.jp/dbget-bin/www_bget?H00243
KEGG_Disease	H00892	http://www.genome.jp/dbget-bin/www_bget?H00892
KEGG_Disease	H01633	http://www.genome.jp/dbget-bin/www_bget?H01633
KEGG_Gene	hsa:6340	http://www.genome.jp/dbget-bin/www_bget?hsa:6340
KEGG_Orthology	KO:K04827	http://www.genome.jp/dbget-bin/www_bget?KO:K04827
KEGG_Pathway	ko04742	http://www.genome.jp/kegg-bin/show_pathway?ko04742
KEGG_Pathway	ko04960	http://www.genome.jp/kegg-bin/show_pathway?ko04960
MIM	177200	http://www.ncbi.nlm.nih.gov/omim/177200
MIM	600761	http://www.ncbi.nlm.nih.gov/omim/600761
MIM	613071	http://www.ncbi.nlm.nih.gov/omim/613071
MINT	MINT-198604	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-198604
OMA	NWMYCYY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NWMYCYY
Orphanet	171876	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=171876
Orphanet	526	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=526
Orphanet	60033	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=60033
OrthoDB	EOG091G0KW6	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0KW6
PANTHER	PTHR11690	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11690
PRINTS	PR01078	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01078
PROSITE	PS01206	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01206
PSORT	swissprot:SCNNG_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SCNNG_HUMAN
PSORT-B	swissprot:SCNNG_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SCNNG_HUMAN
PSORT2	swissprot:SCNNG_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SCNNG_HUMAN
Pfam	PF00858	http://pfam.xfam.org/family/PF00858
PharmGKB	PA307	http://www.pharmgkb.org/do/serve?objId=PA307&objCls=Gene
Phobius	swissprot:SCNNG_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SCNNG_HUMAN
PhylomeDB	P51170	http://phylomedb.org/?seqid=P51170
ProteinModelPortal	P51170	http://www.proteinmodelportal.org/query/uniprot/P51170
PubMed	10391210	http://www.ncbi.nlm.nih.gov/pubmed/10391210
PubMed	10404817	http://www.ncbi.nlm.nih.gov/pubmed/10404817
PubMed	11244092	http://www.ncbi.nlm.nih.gov/pubmed/11244092
PubMed	12107247	http://www.ncbi.nlm.nih.gov/pubmed/12107247
PubMed	12167593	http://www.ncbi.nlm.nih.gov/pubmed/12167593
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	18507830	http://www.ncbi.nlm.nih.gov/pubmed/18507830
PubMed	18650438	http://www.ncbi.nlm.nih.gov/pubmed/18650438
PubMed	19017867	http://www.ncbi.nlm.nih.gov/pubmed/19017867
PubMed	22207244	http://www.ncbi.nlm.nih.gov/pubmed/22207244
PubMed	22493497	http://www.ncbi.nlm.nih.gov/pubmed/22493497
PubMed	23547933	http://www.ncbi.nlm.nih.gov/pubmed/23547933
PubMed	24124190	http://www.ncbi.nlm.nih.gov/pubmed/24124190
PubMed	26772908	http://www.ncbi.nlm.nih.gov/pubmed/26772908
PubMed	7490094	http://www.ncbi.nlm.nih.gov/pubmed/7490094
PubMed	7550319	http://www.ncbi.nlm.nih.gov/pubmed/7550319
PubMed	7762608	http://www.ncbi.nlm.nih.gov/pubmed/7762608
PubMed	8824247	http://www.ncbi.nlm.nih.gov/pubmed/8824247
PubMed	9169421	http://www.ncbi.nlm.nih.gov/pubmed/9169421
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_001030	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001030
STRING	9606.ENSP00000300061	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000300061&targetmode=cogs
TCDB	1.A.6.1	http://www.tcdb.org/search/result.php?tc=1.A.6.1
TIGRFAMs	TIGR00859	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00859
UCSC	uc002dlm	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002dlm&org=rat
UniGene	Hs.371727	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.371727
UniProtKB	SCNNG_HUMAN	http://www.uniprot.org/uniprot/SCNNG_HUMAN
UniProtKB-AC	P51170	http://www.uniprot.org/uniprot/P51170
charge	swissprot:SCNNG_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SCNNG_HUMAN
eggNOG	ENOG410ZNFK	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZNFK
eggNOG	KOG4294	http://eggnogapi.embl.de/nog_data/html/tree/KOG4294
epestfind	swissprot:SCNNG_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SCNNG_HUMAN
garnier	swissprot:SCNNG_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SCNNG_HUMAN
helixturnhelix	swissprot:SCNNG_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SCNNG_HUMAN
hmoment	swissprot:SCNNG_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SCNNG_HUMAN
iep	swissprot:SCNNG_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SCNNG_HUMAN
inforesidue	swissprot:SCNNG_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SCNNG_HUMAN
neXtProt	NX_P51170	http://www.nextprot.org/db/entry/NX_P51170
octanol	swissprot:SCNNG_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SCNNG_HUMAN
pepcoil	swissprot:SCNNG_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SCNNG_HUMAN
pepdigest	swissprot:SCNNG_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SCNNG_HUMAN
pepinfo	swissprot:SCNNG_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SCNNG_HUMAN
pepnet	swissprot:SCNNG_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SCNNG_HUMAN
pepstats	swissprot:SCNNG_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SCNNG_HUMAN
pepwheel	swissprot:SCNNG_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SCNNG_HUMAN
pepwindow	swissprot:SCNNG_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SCNNG_HUMAN
sigcleave	swissprot:SCNNG_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SCNNG_HUMAN
## Database	ID	URL or Descriptions
# AltName	GBRA4_HUMAN	GABA(A) receptor subunit alpha-4
# BioGrid	108831	3
# DrugBank	DB00186	Lorazepam
# DrugBank	DB00189	Ethchlorvynol
# DrugBank	DB00228	Enflurane
# DrugBank	DB00231	Temazepam
# DrugBank	DB00237	Butabarbital
# DrugBank	DB00241	Butalbital
# DrugBank	DB00273	Topiramate
# DrugBank	DB00292	Etomidate
# DrugBank	DB00306	Talbutal
# DrugBank	DB00312	Pentobarbital
# DrugBank	DB00334	Olanzapine
# DrugBank	DB00349	Clobazam
# DrugBank	DB00371	Meprobamate
# DrugBank	DB00402	Eszopiclone
# DrugBank	DB00404	Alprazolam
# DrugBank	DB00418	Secobarbital
# DrugBank	DB00475	Chlordiazepoxide
# DrugBank	DB00543	Amoxapine
# DrugBank	DB00599	Thiopental
# DrugBank	DB00628	Clorazepate
# DrugBank	DB00659	Acamprosate
# DrugBank	DB00683	Midazolam
# DrugBank	DB00690	Flurazepam
# DrugBank	DB00753	Isoflurane
# DrugBank	DB00794	Primidone
# DrugBank	DB00801	Halazepam
# DrugBank	DB00818	Propofol
# DrugBank	DB00829	Diazepam
# DrugBank	DB00842	Oxazepam
# DrugBank	DB00849	Methylphenobarbital
# DrugBank	DB00897	Triazolam
# DrugBank	DB00898	Ethanol
# DrugBank	DB01028	Methoxyflurane
# DrugBank	DB01049	Ergoloid mesylate
# DrugBank	DB01068	Clonazepam
# DrugBank	DB01107	Methyprylon
# DrugBank	DB01159	Halothane
# DrugBank	DB01189	Desflurane
# DrugBank	DB01205	Flumazenil
# DrugBank	DB01215	Estazolam
# DrugBank	DB01236	Sevoflurane
# DrugBank	DB01351	Amobarbital
# DrugBank	DB01352	Aprobarbital
# DrugBank	DB01353	Butethal
# DrugBank	DB01354	Heptabarbital
# DrugBank	DB01355	Hexobarbital
# DrugBank	DB01437	Glutethimide
# DrugBank	DB01544	Flunitrazepam
# DrugBank	DB01558	Bromazepam
# DrugBank	DB01588	Prazepam
# DrugBank	DB01589	Quazepam
# DrugBank	DB01595	Nitrazepam
# Ensembl	ENST00000264318	ENSP00000264318; ENSG00000109158
# ExpressionAtlas	P48169	baseline and differential
# FUNCTION	GBRA4_HUMAN	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:1902711	GABA-A receptor complex; IBA:GO_Central.
# GO_function	GO:0004890	GABA-A receptor activity; IEA:InterPro.
# GO_function	GO:0005230	extracellular ligand-gated ion channel activity; IEA:InterPro.
# GO_function	GO:0005254	chloride channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0008503	benzodiazepine receptor activity; TAS:ProtInc.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007214	gamma-aminobutyric acid signaling pathway; TAS:ProtInc.
# GO_process	GO:0007417	central nervous system development; IEA:Ensembl.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:2001023	regulation of response to drug; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.70.170.10	-; 1.
# Genevisible	P48169	HS
# HGNC	HGNC:4078	GABRA4
# INDUCTION	The alpha4 beta2 gamma 2L receptor is not repressed by diazepam. {ECO:0000269|PubMed	8719416}. 
# InterPro	IPR001390	GABAAa_rcpt
# InterPro	IPR005434	GABBAa4_rcpt
# InterPro	IPR006028	GABAA/Glycine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04727	GABAergic synapse
# KEGG_Pathway	ko05032	Morphine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# MIM	137141	gene
# Organism	GBRA4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR18945	PTHR18945; 2
# PIR	G01928	G01928
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00253	GABAARECEPTR
# PRINTS	PR01079	GABAARALPHA
# PRINTS	PR01617	GABAARALPHA4
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-112314	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
# Reactome	R-HSA-975298	Ligand-gated ion channel transport
# Reactome	R-HSA-977441	GABA A receptor activation
# RecName	GBRA4_HUMAN	Gamma-aminobutyric acid receptor subunit alpha-4
# RefSeq	NP_000800	NM_000809.3
# RefSeq	NP_001191195	NM_001204266.1
# RefSeq	NP_001191196	NM_001204267.1
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA4 sub-subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	GBRA4_HUMAN	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Generally pentameric. There are five types of GABA(A) receptor chains	 alpha, beta, gamma, delta, and rho. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112; 2
# TIGRFAMs	TIGR00860	LIC
# WEB RESOURCE	GBRA4_HUMAN	Name=Protein Spotlight; Note=Forbidden fruit - Issue 56 of March 2005; URL="http //web.expasy.org/spotlight/back_issues/056";
# eggNOG	ENOG410XNQG	LUCA
# eggNOG	KOG3642	Eukaryota
BLAST	swissprot:GBRA4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GBRA4_HUMAN
BioCyc	ZFISH:ENSG00000109158-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000109158-MONOMER
COXPRESdb	2557	http://coxpresdb.jp/data/gene/2557.shtml
CleanEx	HS_GABRA4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GABRA4
DOI	10.1016/0888-7543(95)80178-O	http://dx.doi.org/10.1016/0888-7543(95)80178-O
DOI	10.1016/0922-4106(95)90072-1	http://dx.doi.org/10.1016/0922-4106(95)90072-1
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DrugBank	DB00186	http://www.drugbank.ca/drugs/DB00186
DrugBank	DB00189	http://www.drugbank.ca/drugs/DB00189
DrugBank	DB00228	http://www.drugbank.ca/drugs/DB00228
DrugBank	DB00231	http://www.drugbank.ca/drugs/DB00231
DrugBank	DB00237	http://www.drugbank.ca/drugs/DB00237
DrugBank	DB00241	http://www.drugbank.ca/drugs/DB00241
DrugBank	DB00273	http://www.drugbank.ca/drugs/DB00273
DrugBank	DB00292	http://www.drugbank.ca/drugs/DB00292
DrugBank	DB00306	http://www.drugbank.ca/drugs/DB00306
DrugBank	DB00312	http://www.drugbank.ca/drugs/DB00312
DrugBank	DB00334	http://www.drugbank.ca/drugs/DB00334
DrugBank	DB00349	http://www.drugbank.ca/drugs/DB00349
DrugBank	DB00371	http://www.drugbank.ca/drugs/DB00371
DrugBank	DB00402	http://www.drugbank.ca/drugs/DB00402
DrugBank	DB00404	http://www.drugbank.ca/drugs/DB00404
DrugBank	DB00418	http://www.drugbank.ca/drugs/DB00418
DrugBank	DB00475	http://www.drugbank.ca/drugs/DB00475
DrugBank	DB00543	http://www.drugbank.ca/drugs/DB00543
DrugBank	DB00599	http://www.drugbank.ca/drugs/DB00599
DrugBank	DB00628	http://www.drugbank.ca/drugs/DB00628
DrugBank	DB00659	http://www.drugbank.ca/drugs/DB00659
DrugBank	DB00683	http://www.drugbank.ca/drugs/DB00683
DrugBank	DB00690	http://www.drugbank.ca/drugs/DB00690
DrugBank	DB00753	http://www.drugbank.ca/drugs/DB00753
DrugBank	DB00794	http://www.drugbank.ca/drugs/DB00794
DrugBank	DB00801	http://www.drugbank.ca/drugs/DB00801
DrugBank	DB00818	http://www.drugbank.ca/drugs/DB00818
DrugBank	DB00829	http://www.drugbank.ca/drugs/DB00829
DrugBank	DB00842	http://www.drugbank.ca/drugs/DB00842
DrugBank	DB00849	http://www.drugbank.ca/drugs/DB00849
DrugBank	DB00897	http://www.drugbank.ca/drugs/DB00897
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01028	http://www.drugbank.ca/drugs/DB01028
DrugBank	DB01049	http://www.drugbank.ca/drugs/DB01049
DrugBank	DB01068	http://www.drugbank.ca/drugs/DB01068
DrugBank	DB01107	http://www.drugbank.ca/drugs/DB01107
DrugBank	DB01159	http://www.drugbank.ca/drugs/DB01159
DrugBank	DB01189	http://www.drugbank.ca/drugs/DB01189
DrugBank	DB01205	http://www.drugbank.ca/drugs/DB01205
DrugBank	DB01215	http://www.drugbank.ca/drugs/DB01215
DrugBank	DB01236	http://www.drugbank.ca/drugs/DB01236
DrugBank	DB01351	http://www.drugbank.ca/drugs/DB01351
DrugBank	DB01352	http://www.drugbank.ca/drugs/DB01352
DrugBank	DB01353	http://www.drugbank.ca/drugs/DB01353
DrugBank	DB01354	http://www.drugbank.ca/drugs/DB01354
DrugBank	DB01355	http://www.drugbank.ca/drugs/DB01355
DrugBank	DB01437	http://www.drugbank.ca/drugs/DB01437
DrugBank	DB01544	http://www.drugbank.ca/drugs/DB01544
DrugBank	DB01558	http://www.drugbank.ca/drugs/DB01558
DrugBank	DB01588	http://www.drugbank.ca/drugs/DB01588
DrugBank	DB01589	http://www.drugbank.ca/drugs/DB01589
DrugBank	DB01595	http://www.drugbank.ca/drugs/DB01595
EMBL	AC107383	http://www.ebi.ac.uk/ena/data/view/AC107383
EMBL	AK090780	http://www.ebi.ac.uk/ena/data/view/AK090780
EMBL	BC035055	http://www.ebi.ac.uk/ena/data/view/BC035055
EMBL	CH471069	http://www.ebi.ac.uk/ena/data/view/CH471069
EMBL	U20166	http://www.ebi.ac.uk/ena/data/view/U20166
EMBL	U30461	http://www.ebi.ac.uk/ena/data/view/U30461
Ensembl	ENST00000264318	http://www.ensembl.org/id/ENST00000264318
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_component	GO:1902711	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902711
GO_function	GO:0004890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004890
GO_function	GO:0005230	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005230
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0008503	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008503
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007214	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007214
GO_process	GO:0007417	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007417
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:2001023	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001023
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	GABRA4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GABRA4
GeneID	2557	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2557
GeneTree	ENSGT00760000119010	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119010
HGNC	HGNC:4078	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4078
HOGENOM	HOG000231337	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231337&db=HOGENOM6
HOVERGEN	HBG051707	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051707&db=HOVERGEN
InParanoid	P48169	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P48169
IntAct	P48169	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P48169*
InterPro	IPR001390	http://www.ebi.ac.uk/interpro/entry/IPR001390
InterPro	IPR005434	http://www.ebi.ac.uk/interpro/entry/IPR005434
InterPro	IPR006028	http://www.ebi.ac.uk/interpro/entry/IPR006028
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
Jabion	2557	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2557
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:2557	http://www.genome.jp/dbget-bin/www_bget?hsa:2557
KEGG_Orthology	KO:K05175	http://www.genome.jp/dbget-bin/www_bget?KO:K05175
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
KEGG_Pathway	ko05032	http://www.genome.jp/kegg-bin/show_pathway?ko05032
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
MIM	137141	http://www.ncbi.nlm.nih.gov/omim/137141
OMA	THANLNM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=THANLNM
OrthoDB	EOG091G0805	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0805
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00253	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00253
PRINTS	PR01079	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01079
PRINTS	PR01617	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01617
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:GBRA4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GBRA4_HUMAN
PSORT-B	swissprot:GBRA4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GBRA4_HUMAN
PSORT2	swissprot:GBRA4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GBRA4_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA28492	http://www.pharmgkb.org/do/serve?objId=PA28492&objCls=Gene
Phobius	swissprot:GBRA4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GBRA4_HUMAN
PhylomeDB	P48169	http://phylomedb.org/?seqid=P48169
ProteinModelPortal	P48169	http://www.proteinmodelportal.org/query/uniprot/P48169
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	7607683	http://www.ncbi.nlm.nih.gov/pubmed/7607683
PubMed	8719416	http://www.ncbi.nlm.nih.gov/pubmed/8719416
Reactome	R-HSA-112314	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112314
Reactome	R-HSA-975298	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-975298
Reactome	R-HSA-977441	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-977441
RefSeq	NP_000800	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000800
RefSeq	NP_001191195	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001191195
RefSeq	NP_001191196	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001191196
SMR	P48169	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P48169
STRING	9606.ENSP00000264318	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000264318&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UniGene	Hs.248112	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.248112
UniProtKB	GBRA4_HUMAN	http://www.uniprot.org/uniprot/GBRA4_HUMAN
UniProtKB-AC	P48169	http://www.uniprot.org/uniprot/P48169
charge	swissprot:GBRA4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GBRA4_HUMAN
eggNOG	ENOG410XNQG	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNQG
eggNOG	KOG3642	http://eggnogapi.embl.de/nog_data/html/tree/KOG3642
epestfind	swissprot:GBRA4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GBRA4_HUMAN
garnier	swissprot:GBRA4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GBRA4_HUMAN
helixturnhelix	swissprot:GBRA4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GBRA4_HUMAN
hmoment	swissprot:GBRA4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GBRA4_HUMAN
iep	swissprot:GBRA4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GBRA4_HUMAN
inforesidue	swissprot:GBRA4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GBRA4_HUMAN
neXtProt	NX_P48169	http://www.nextprot.org/db/entry/NX_P48169
octanol	swissprot:GBRA4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GBRA4_HUMAN
pepcoil	swissprot:GBRA4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GBRA4_HUMAN
pepdigest	swissprot:GBRA4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GBRA4_HUMAN
pepinfo	swissprot:GBRA4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GBRA4_HUMAN
pepnet	swissprot:GBRA4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GBRA4_HUMAN
pepstats	swissprot:GBRA4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GBRA4_HUMAN
pepwheel	swissprot:GBRA4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GBRA4_HUMAN
pepwindow	swissprot:GBRA4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GBRA4_HUMAN
sigcleave	swissprot:GBRA4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GBRA4_HUMAN
## Database	ID	URL or Descriptions
# AltName	COX8A_HUMAN	Cytochrome c oxidase polypeptide VIII-liver/heart
# AltName	COX8A_HUMAN	Cytochrome c oxidase subunit 8-2
# BioGrid	107744	4
# ChiTaRS	COX8A	human
# DrugBank	DB02659	Cholic Acid
# Ensembl	ENST00000314133	ENSP00000321260; ENSG00000176340
# ExpressionAtlas	P10176	baseline and differential
# FUNCTION	COX8A_HUMAN	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. 
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0005751	mitochondrial respiratory chain complex IV; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0004129	cytochrome-c oxidase activity; TAS:ProtInc.
# GO_process	GO:0006091	generation of precursor metabolites and energy; TAS:ProtInc.
# GO_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# Gene3D	4.10.81.10	-; 1.
# Genevisible	P10176	HS
# HGNC	HGNC:2294	COX8A
# INTERACTION	COX8A_HUMAN	P06748 NPM1; NbExp=3; IntAct=EBI-3904738, EBI-78579; 
# IntAct	P10176	5
# InterPro	IPR003205	Cyt_c_oxidase_su8
# InterPro	IPR016070	Cyt_c_oxidase_su8/PSI_RC_su9
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	123870	gene
# Organism	COX8A_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR16717	PTHR16717
# PIR	A34103	OSHU8
# Pfam	PF02285	COX8
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-5628897	TP53 Regulates Metabolic Genes
# Reactome	R-HSA-611105	Respiratory electron transport
# RecName	COX8A_HUMAN	Cytochrome c oxidase subunit 8A, mitochondrial
# RefSeq	NP_004065	NM_004074.2
# SIMILARITY	Belongs to the cytochrome c oxidase VIII family. {ECO	0000305}.
# SUBCELLULAR LOCATION	COX8A_HUMAN	Mitochondrion inner membrane. 
# SUPFAM	SSF81431	SSF81431
# TCDB	3.D.4.11	the proton-translocating cytochrome oxidase (cox) superfamily
# eggNOG	ENOG410J4WR	Eukaryota
# eggNOG	ENOG410ZEYR	LUCA
BLAST	swissprot:COX8A_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:COX8A_HUMAN
BioCyc	ZFISH:HS11040-MONOMER	http://biocyc.org/getid?id=ZFISH:HS11040-MONOMER
COXPRESdb	1351	http://coxpresdb.jp/data/gene/1351.shtml
CleanEx	HS_COX8A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_COX8A
DOI	10.1016/0014-5793(88)80353-3	http://dx.doi.org/10.1016/0014-5793(88)80353-3
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB02659	http://www.drugbank.ca/drugs/DB02659
EMBL	BC063025	http://www.ebi.ac.uk/ena/data/view/BC063025
EMBL	J04823	http://www.ebi.ac.uk/ena/data/view/J04823
Ensembl	ENST00000314133	http://www.ensembl.org/id/ENST00000314133
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005751	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005751
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0004129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004129
GO_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GO_process	GO:0006123	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006123
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
Gene3D	4.10.81.10	http://www.cathdb.info/version/latest/superfamily/4.10.81.10
GeneCards	COX8A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=COX8A
GeneID	1351	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1351
GeneTree	ENSGT00390000006255	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000006255
HGNC	HGNC:2294	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2294
HOGENOM	HOG000230478	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230478&db=HOGENOM6
HPA	HPA055942	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA055942
InParanoid	P10176	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P10176
IntAct	P10176	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P10176*
InterPro	IPR003205	http://www.ebi.ac.uk/interpro/entry/IPR003205
InterPro	IPR016070	http://www.ebi.ac.uk/interpro/entry/IPR016070
Jabion	1351	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1351
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Gene	hsa:1351	http://www.genome.jp/dbget-bin/www_bget?hsa:1351
KEGG_Orthology	KO:K02273	http://www.genome.jp/dbget-bin/www_bget?KO:K02273
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	123870	http://www.ncbi.nlm.nih.gov/omim/123870
OMA	IGLTSCF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IGLTSCF
OrthoDB	EOG091G11UL	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G11UL
PANTHER	PTHR16717	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16717
PSORT	swissprot:COX8A_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:COX8A_HUMAN
PSORT-B	swissprot:COX8A_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:COX8A_HUMAN
PSORT2	swissprot:COX8A_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:COX8A_HUMAN
Pfam	PF02285	http://pfam.xfam.org/family/PF02285
PharmGKB	PA26814	http://www.pharmgkb.org/do/serve?objId=PA26814&objCls=Gene
Phobius	swissprot:COX8A_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:COX8A_HUMAN
PhylomeDB	P10176	http://phylomedb.org/?seqid=P10176
ProteinModelPortal	P10176	http://www.proteinmodelportal.org/query/uniprot/P10176
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	2543673	http://www.ncbi.nlm.nih.gov/pubmed/2543673
PubMed	2847943	http://www.ncbi.nlm.nih.gov/pubmed/2847943
Reactome	R-HSA-5628897	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5628897
Reactome	R-HSA-611105	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-611105
RefSeq	NP_004065	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004065
SMR	P10176	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P10176
STRING	9606.ENSP00000321260	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000321260&targetmode=cogs
SUPFAM	SSF81431	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81431
TCDB	3.D.4.11	http://www.tcdb.org/search/result.php?tc=3.D.4.11
UniGene	Hs.743989	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.743989
UniProtKB	COX8A_HUMAN	http://www.uniprot.org/uniprot/COX8A_HUMAN
UniProtKB-AC	P10176	http://www.uniprot.org/uniprot/P10176
charge	swissprot:COX8A_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:COX8A_HUMAN
eggNOG	ENOG410J4WR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410J4WR
eggNOG	ENOG410ZEYR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZEYR
epestfind	swissprot:COX8A_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:COX8A_HUMAN
garnier	swissprot:COX8A_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:COX8A_HUMAN
helixturnhelix	swissprot:COX8A_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:COX8A_HUMAN
hmoment	swissprot:COX8A_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:COX8A_HUMAN
iep	swissprot:COX8A_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:COX8A_HUMAN
inforesidue	swissprot:COX8A_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:COX8A_HUMAN
neXtProt	NX_P10176	http://www.nextprot.org/db/entry/NX_P10176
octanol	swissprot:COX8A_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:COX8A_HUMAN
pepcoil	swissprot:COX8A_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:COX8A_HUMAN
pepdigest	swissprot:COX8A_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:COX8A_HUMAN
pepinfo	swissprot:COX8A_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:COX8A_HUMAN
pepnet	swissprot:COX8A_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:COX8A_HUMAN
pepstats	swissprot:COX8A_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:COX8A_HUMAN
pepwheel	swissprot:COX8A_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:COX8A_HUMAN
pepwindow	swissprot:COX8A_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:COX8A_HUMAN
sigcleave	swissprot:COX8A_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:COX8A_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNQ4_HUMAN	Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=1; IsoId=P56696-1; Sequence=Displayed; Name=2; IsoId=P56696-2; Sequence=VSP_001013; 
# AltName	KCNQ4_HUMAN	KQT-like 4
# AltName	KCNQ4_HUMAN	Potassium channel subunit alpha KvLQT4
# AltName	KCNQ4_HUMAN	Voltage-gated potassium channel subunit Kv7.4
# BioGrid	114580	6
# CCDS	CCDS456	-. [P56696-1]
# ChiTaRS	KCNQ4	human
# DISEASE	KCNQ4_HUMAN	Deafness, autosomal dominant, 2A (DFNA2A) [MIM 600101]  A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO 0000269|PubMed 10025409, ECO 0000269|PubMed 10369879, ECO 0000269|PubMed 10571947, ECO 0000269|PubMed 10925378, ECO 0000269|PubMed 21242547}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	KCNQ4_HUMAN	The A-domain tail carries the major determinants of channel assembly specificity. Its coiled-coil region is Four- stranded. {ECO 0000269|PubMed 17329207}. 
# DOMAIN	KCNQ4_HUMAN	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. {ECO 0000250}. 
# DrugBank	DB04953	Ezogabine
# Ensembl	ENST00000347132	ENSP00000262916; ENSG00000117013. [P56696-1]
# Ensembl	ENST00000509682	ENSP00000423756; ENSG00000117013. [P56696-2]
# ExpressionAtlas	P56696	baseline and differential
# FUNCTION	KCNQ4_HUMAN	Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IEA:InterPro.
# GO_component	GO:0009925	basal plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016021	integral component of membrane; IBA:GO_Central.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; IBA:GO_Central.
# GO_function	GO:0005267	potassium channel activity; TAS:ProtInc.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0007605	sensory perception of sound; TAS:ProtInc.
# GO_process	GO:0042472	inner ear morphogenesis; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# Genevisible	P56696	HS
# HGNC	HGNC:6298	KCNQ4
# InterPro	IPR003937	K_chnl_volt-dep_KCNQ
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR013821	K_chnl_volt-dep_KCNQ_C
# InterPro	IPR015573	KCQN4
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00604	[Nervous system disease; Nervous system disease] Deafness, autosomal dominant
# KEGG_Pathway	ko04725	Cholinergic synapse
# MIM	600101	phenotype
# MIM	603537	gene
# MISCELLANEOUS	Mutagenesis experiments were carried out by expressing in Xenopus oocytes KCNQ4 mutants either individually (homomultimers) or in combination with wild-type KCNQ4 (mut/wt homomultimers) in a ratio of 1	1, to mimic the situation in a heterozygous DFNA2 patient. 
# Organism	KCNQ4_HUMAN	Homo sapiens (Human)
# Orphanet	90635	Autosomal dominant non-syndromic sensorineural deafness type DFNA
# PANTHER	PTHR11537	PTHR11537; 3
# PANTHER	PTHR11537:SF4	PTHR11537:SF4; 3
# PDB	2OVC	X-ray; 2.07 A; A=610-640
# PDB	4GOW	X-ray; 2.60 A; A=522-593
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01459	KCNQCHANNEL
# Pfam	PF00520	Ion_trans
# Pfam	PF03520	KCNQ_channel
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# RecName	KCNQ4_HUMAN	Potassium voltage-gated channel subfamily KQT member 4
# RefSeq	NP_004691	NM_004700.3. [P56696-1]
# RefSeq	NP_751895	NM_172163.2. [P56696-2]
# SIMILARITY	Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.4/KCNQ4 sub-subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	KCNQ4_HUMAN	Basal cell membrane; Multi-pass membrane protein. Note=Situated at the basal membrane of cochlear outer hair cells. {ECO 0000250}. 
# SUBUNIT	Homotetramer. May form heteromultimers with KCNQ3. {ECO:0000269|PubMed	17329207}. 
# TCDB	1.A.1.15	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	KCNQ4_HUMAN	Expressed in the outer, but not the inner, sensory hair cells of the cochlea. Slightly expressed in heart, brain and skeletal muscle. 
# UCSC	uc001cgh	human. [P56696-1]
# WEB RESOURCE	KCNQ4_HUMAN	Name=Hereditary hearing loss homepage; Note=Gene page; URL="http //hereditaryhearingloss.org/main.aspx?c=.HHH&n=86162";
# eggNOG	COG1226	LUCA
# eggNOG	KOG1419	Eukaryota
BLAST	swissprot:KCNQ4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNQ4_HUMAN
BioCyc	ZFISH:ENSG00000117013-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000117013-MONOMER
COXPRESdb	9132	http://coxpresdb.jp/data/gene/9132.shtml
CleanEx	HS_KCNQ4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNQ4
DOI	10.1001/archoto.2010.234	http://dx.doi.org/10.1001/archoto.2010.234
DOI	10.1002/(SICI)1098-1004(199912)14:6<493::AID-HUMU8>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(199912)14:6<493::AID-HUMU8>3.0.CO
DOI	10.1002/1096-8628(20000731)93:3<184::AID-AJMG4>3.0.CO	http://dx.doi.org/10.1002/1096-8628(20000731)93:3<184::AID-AJMG4>3.0.CO
DOI	10.1016/S0092-8674(00)80556-5	http://dx.doi.org/10.1016/S0092-8674(00)80556-5
DOI	10.1016/j.neuron.2007.02.010	http://dx.doi.org/10.1016/j.neuron.2007.02.010
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1093/hmg/8.7.1321	http://dx.doi.org/10.1093/hmg/8.7.1321
DOI	10.1111/j.1469-7793.2000.t01-2-00349.x	http://dx.doi.org/10.1111/j.1469-7793.2000.t01-2-00349.x
DrugBank	DB04953	http://www.drugbank.ca/drugs/DB04953
EMBL	AC119677	http://www.ebi.ac.uk/ena/data/view/AC119677
EMBL	AF105202	http://www.ebi.ac.uk/ena/data/view/AF105202
EMBL	AF105203	http://www.ebi.ac.uk/ena/data/view/AF105203
EMBL	AF105204	http://www.ebi.ac.uk/ena/data/view/AF105204
EMBL	AF105205	http://www.ebi.ac.uk/ena/data/view/AF105205
EMBL	AF105206	http://www.ebi.ac.uk/ena/data/view/AF105206
EMBL	AF105207	http://www.ebi.ac.uk/ena/data/view/AF105207
EMBL	AF105208	http://www.ebi.ac.uk/ena/data/view/AF105208
EMBL	AF105209	http://www.ebi.ac.uk/ena/data/view/AF105209
EMBL	AF105210	http://www.ebi.ac.uk/ena/data/view/AF105210
EMBL	AF105211	http://www.ebi.ac.uk/ena/data/view/AF105211
EMBL	AF105212	http://www.ebi.ac.uk/ena/data/view/AF105212
EMBL	AF105213	http://www.ebi.ac.uk/ena/data/view/AF105213
EMBL	AF105214	http://www.ebi.ac.uk/ena/data/view/AF105214
EMBL	AF105215	http://www.ebi.ac.uk/ena/data/view/AF105215
EMBL	AF105216	http://www.ebi.ac.uk/ena/data/view/AF105216
Ensembl	ENST00000347132	http://www.ensembl.org/id/ENST00000347132
Ensembl	ENST00000509682	http://www.ensembl.org/id/ENST00000509682
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0009925	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009925
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0007605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007605
GO_process	GO:0042472	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042472
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	KCNQ4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNQ4
GeneID	9132	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9132
GeneTree	ENSGT00550000074513	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074513
H-InvDB	HIX0200020	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0200020
HGNC	HGNC:6298	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6298
HOGENOM	HOG000220839	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220839&db=HOGENOM6
HOVERGEN	HBG059014	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG059014&db=HOVERGEN
HPA	HPA018305	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA018305
InParanoid	P56696	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P56696
InterPro	IPR003937	http://www.ebi.ac.uk/interpro/entry/IPR003937
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR013821	http://www.ebi.ac.uk/interpro/entry/IPR013821
InterPro	IPR015573	http://www.ebi.ac.uk/interpro/entry/IPR015573
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	9132	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9132
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00604	http://www.genome.jp/dbget-bin/www_bget?H00604
KEGG_Gene	hsa:9132	http://www.genome.jp/dbget-bin/www_bget?hsa:9132
KEGG_Orthology	KO:K04929	http://www.genome.jp/dbget-bin/www_bget?KO:K04929
KEGG_Pathway	ko04725	http://www.genome.jp/kegg-bin/show_pathway?ko04725
MIM	600101	http://www.ncbi.nlm.nih.gov/omim/600101
MIM	603537	http://www.ncbi.nlm.nih.gov/omim/603537
OMA	WAFVYHV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WAFVYHV
Orphanet	90635	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=90635
OrthoDB	EOG091G02ZT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02ZT
PANTHER	PTHR11537	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537
PANTHER	PTHR11537:SF4	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537:SF4
PDB	2OVC	http://www.ebi.ac.uk/pdbe-srv/view/entry/2OVC
PDB	4GOW	http://www.ebi.ac.uk/pdbe-srv/view/entry/4GOW
PDBsum	2OVC	http://www.ebi.ac.uk/pdbsum/2OVC
PDBsum	4GOW	http://www.ebi.ac.uk/pdbsum/4GOW
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01459	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01459
PSORT	swissprot:KCNQ4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNQ4_HUMAN
PSORT-B	swissprot:KCNQ4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNQ4_HUMAN
PSORT2	swissprot:KCNQ4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNQ4_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF03520	http://pfam.xfam.org/family/PF03520
PharmGKB	PA30076	http://www.pharmgkb.org/do/serve?objId=PA30076&objCls=Gene
Phobius	swissprot:KCNQ4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNQ4_HUMAN
PhylomeDB	P56696	http://phylomedb.org/?seqid=P56696
ProteinModelPortal	P56696	http://www.proteinmodelportal.org/query/uniprot/P56696
PubMed	10025409	http://www.ncbi.nlm.nih.gov/pubmed/10025409
PubMed	10369879	http://www.ncbi.nlm.nih.gov/pubmed/10369879
PubMed	10571947	http://www.ncbi.nlm.nih.gov/pubmed/10571947
PubMed	10713961	http://www.ncbi.nlm.nih.gov/pubmed/10713961
PubMed	10925378	http://www.ncbi.nlm.nih.gov/pubmed/10925378
PubMed	11245603	http://www.ncbi.nlm.nih.gov/pubmed/11245603
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17329207	http://www.ncbi.nlm.nih.gov/pubmed/17329207
PubMed	21242547	http://www.ncbi.nlm.nih.gov/pubmed/21242547
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
RefSeq	NP_004691	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004691
RefSeq	NP_751895	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_751895
SMR	P56696	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P56696
STRING	9606.ENSP00000262916	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000262916&targetmode=cogs
TCDB	1.A.1.15	http://www.tcdb.org/search/result.php?tc=1.A.1.15
UCSC	uc001cgh	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001cgh&org=rat
UniGene	Hs.473058	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.473058
UniProtKB	KCNQ4_HUMAN	http://www.uniprot.org/uniprot/KCNQ4_HUMAN
UniProtKB-AC	P56696	http://www.uniprot.org/uniprot/P56696
charge	swissprot:KCNQ4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNQ4_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG1419	http://eggnogapi.embl.de/nog_data/html/tree/KOG1419
epestfind	swissprot:KCNQ4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNQ4_HUMAN
garnier	swissprot:KCNQ4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNQ4_HUMAN
helixturnhelix	swissprot:KCNQ4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNQ4_HUMAN
hmoment	swissprot:KCNQ4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNQ4_HUMAN
iep	swissprot:KCNQ4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNQ4_HUMAN
inforesidue	swissprot:KCNQ4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNQ4_HUMAN
neXtProt	NX_P56696	http://www.nextprot.org/db/entry/NX_P56696
octanol	swissprot:KCNQ4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNQ4_HUMAN
pepcoil	swissprot:KCNQ4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNQ4_HUMAN
pepdigest	swissprot:KCNQ4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNQ4_HUMAN
pepinfo	swissprot:KCNQ4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNQ4_HUMAN
pepnet	swissprot:KCNQ4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNQ4_HUMAN
pepstats	swissprot:KCNQ4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNQ4_HUMAN
pepwheel	swissprot:KCNQ4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNQ4_HUMAN
pepwindow	swissprot:KCNQ4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNQ4_HUMAN
sigcleave	swissprot:KCNQ4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNQ4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SL9B1_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q4ZJI4-1; Sequence=Displayed; Name=2; IsoId=Q4ZJI4-2; Sequence=VSP_030175, VSP_030180; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; IsoId=Q4ZJI4-3; Sequence=VSP_030180; Name=4; IsoId=Q4ZJI4-5; Sequence=VSP_030176, VSP_030177; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 
# AltName	SL9B1_HUMAN	Na(+)/H(+) exchanger-like domain-containing protein 1
# AltName	SL9B1_HUMAN	Sodium/hydrogen exchanger-like domain-containing protein 1
# AltName	SL9B1_HUMAN	Solute carrier family 9 subfamily B member 1
# CCDS	CCDS34041	-. [Q4ZJI4-1]
# CCDS	CCDS47119	-. [Q4ZJI4-3]
# ChiTaRS	SLC9B1	human
# Ensembl	ENST00000296422	ENSP00000296422; ENSG00000164037. [Q4ZJI4-1]
# Ensembl	ENST00000394789	ENSP00000378269; ENSG00000164037. [Q4ZJI4-3]
# Ensembl	ENST00000503584	ENSP00000426926; ENSG00000164037. [Q4ZJI4-5]
# Ensembl	ENST00000510243	ENSP00000425913; ENSG00000164037. [Q4ZJI4-5]
# ExpressionAtlas	Q4ZJI4	baseline and differential
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	SL9B1_HUMAN	GO 0015385 sodium proton antiporter activity; TAS Reactome.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q4ZJI4	HS
# HGNC	HGNC:24244	SLC9B1
# InterPro	IPR006153	Cation/H_exchanger
# MIM	611527	gene
# Organism	SL9B1_HUMAN	Homo sapiens (Human)
# Pfam	PF00999	Na_H_Exchanger
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	SL9B1_HUMAN	Sodium/hydrogen exchanger 9B1
# RefSeq	NP_001094344	NM_001100874.2
# RefSeq	NP_631912	NM_139173.3
# RefSeq	XP_006714156	XM_006714093.3. [Q4ZJI4-1]
# RefSeq	XP_011529924	XM_011531622.1. [Q4ZJI4-1]
# RefSeq	XP_011529925	XM_011531623.1. [Q4ZJI4-1]
# SEQUENCE CAUTION	Sequence=AAM22868.1; Type=Frameshift; Positions=219, 298, 381; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	SL9B1_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	2.A.36.2:the monovalent cation	proton antiporter-1 (cpa1) family
# TISSUE SPECIFICITY	Expressed only in the testis. {ECO:0000269|PubMed	16850186}. 
# UCSC	uc003hwu	human. [Q4ZJI4-1]
# eggNOG	COG0025	LUCA
# eggNOG	KOG3826	Eukaryota
BLAST	swissprot:SL9B1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SL9B1_HUMAN
BioCyc	ZFISH:G66-31690-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31690-MONOMER
COXPRESdb	150159	http://coxpresdb.jp/data/gene/150159.shtml
CleanEx	HS_NHEDC1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_NHEDC1
DOI	10.1007/s11033-006-0010-y	http://dx.doi.org/10.1007/s11033-006-0010-y
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC018797	http://www.ebi.ac.uk/ena/data/view/AC018797
EMBL	AC083826	http://www.ebi.ac.uk/ena/data/view/AC083826
EMBL	AF447585	http://www.ebi.ac.uk/ena/data/view/AF447585
EMBL	AY461581	http://www.ebi.ac.uk/ena/data/view/AY461581
EMBL	BC022079	http://www.ebi.ac.uk/ena/data/view/BC022079
EMBL	BC046636	http://www.ebi.ac.uk/ena/data/view/BC046636
EMBL	BC110794	http://www.ebi.ac.uk/ena/data/view/BC110794
EMBL	BC132712	http://www.ebi.ac.uk/ena/data/view/BC132712
EMBL	BC136966	http://www.ebi.ac.uk/ena/data/view/BC136966
EMBL	CH471057	http://www.ebi.ac.uk/ena/data/view/CH471057
EMBL	DQ003059	http://www.ebi.ac.uk/ena/data/view/DQ003059
Ensembl	ENST00000296422	http://www.ensembl.org/id/ENST00000296422
Ensembl	ENST00000394789	http://www.ensembl.org/id/ENST00000394789
Ensembl	ENST00000503584	http://www.ensembl.org/id/ENST00000503584
Ensembl	ENST00000510243	http://www.ensembl.org/id/ENST00000510243
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015385
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC9B1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC9B1
GeneID	150159	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=150159
GeneTree	ENSGT00390000013285	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000013285
HGNC	HGNC:24244	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:24244
HOVERGEN	HBG108184	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108184&db=HOVERGEN
HPA	HPA035435	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035435
InParanoid	Q4ZJI4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q4ZJI4
InterPro	IPR006153	http://www.ebi.ac.uk/interpro/entry/IPR006153
Jabion	150159	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=150159
KEGG_Gene	hsa:150159	http://www.genome.jp/dbget-bin/www_bget?hsa:150159
MIM	611527	http://www.ncbi.nlm.nih.gov/omim/611527
OMA	PCLMEAC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PCLMEAC
OrthoDB	EOG091G06PH	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G06PH
PSORT	swissprot:SL9B1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SL9B1_HUMAN
PSORT-B	swissprot:SL9B1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SL9B1_HUMAN
PSORT2	swissprot:SL9B1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SL9B1_HUMAN
Pfam	PF00999	http://pfam.xfam.org/family/PF00999
PharmGKB	PA162397486	http://www.pharmgkb.org/do/serve?objId=PA162397486&objCls=Gene
Phobius	swissprot:SL9B1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SL9B1_HUMAN
PhylomeDB	Q4ZJI4	http://phylomedb.org/?seqid=Q4ZJI4
ProteinModelPortal	Q4ZJI4	http://www.proteinmodelportal.org/query/uniprot/Q4ZJI4
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	16850186	http://www.ncbi.nlm.nih.gov/pubmed/16850186
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_001094344	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001094344
RefSeq	NP_631912	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_631912
RefSeq	XP_006714156	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006714156
RefSeq	XP_011529924	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011529924
RefSeq	XP_011529925	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011529925
SMR	Q4ZJI4	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q4ZJI4
STRING	9606.ENSP00000296422	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000296422&targetmode=cogs
TCDB	2.A.36.2	http://www.tcdb.org/search/result.php?tc=2.A.36.2
UCSC	uc003hwu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003hwu&org=rat
UniGene	Hs.666728	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.666728
UniProtKB	SL9B1_HUMAN	http://www.uniprot.org/uniprot/SL9B1_HUMAN
UniProtKB-AC	Q4ZJI4	http://www.uniprot.org/uniprot/Q4ZJI4
charge	swissprot:SL9B1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SL9B1_HUMAN
eggNOG	COG0025	http://eggnogapi.embl.de/nog_data/html/tree/COG0025
eggNOG	KOG3826	http://eggnogapi.embl.de/nog_data/html/tree/KOG3826
epestfind	swissprot:SL9B1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SL9B1_HUMAN
garnier	swissprot:SL9B1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SL9B1_HUMAN
helixturnhelix	swissprot:SL9B1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SL9B1_HUMAN
hmoment	swissprot:SL9B1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SL9B1_HUMAN
iep	swissprot:SL9B1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SL9B1_HUMAN
inforesidue	swissprot:SL9B1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SL9B1_HUMAN
neXtProt	NX_Q4ZJI4	http://www.nextprot.org/db/entry/NX_Q4ZJI4
octanol	swissprot:SL9B1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SL9B1_HUMAN
pepcoil	swissprot:SL9B1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SL9B1_HUMAN
pepdigest	swissprot:SL9B1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SL9B1_HUMAN
pepinfo	swissprot:SL9B1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SL9B1_HUMAN
pepnet	swissprot:SL9B1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SL9B1_HUMAN
pepstats	swissprot:SL9B1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SL9B1_HUMAN
pepwheel	swissprot:SL9B1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SL9B1_HUMAN
pepwindow	swissprot:SL9B1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SL9B1_HUMAN
sigcleave	swissprot:SL9B1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SL9B1_HUMAN
## Database	ID	URL or Descriptions
# AltName	SERC1_HUMAN	Tumor differentially expressed protein 1-like
# AltName	SERC1_HUMAN	Tumor differentially expressed protein 2
# BioGrid	121579	33
# ChiTaRS	SERINC1	human
# Ensembl	ENST00000339697	ENSP00000342962; ENSG00000111897
# FUNCTION	SERC1_HUMAN	Enhances the incorporation of serine into phosphatidylserine and sphingolipids. {ECO 0000250|UniProtKB Q7TNK0}. 
# GO_component	GO:0005789	endoplasmic reticulum membrane; ISS:HGNC.
# GO_component	GO:0005886	plasma membrane; ISS:HGNC.
# GO_component	GO:0016021	integral component of membrane; IBA:GO_Central.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0015194	L-serine transmembrane transporter activity; ISS:HGNC.
# GO_process	GO:0006658	phosphatidylserine metabolic process; ISS:HGNC.
# GO_process	GO:0006665	sphingolipid metabolic process; ISS:HGNC.
# GO_process	GO:0008654	phospholipid biosynthetic process; IEA:UniProtKB-KW.
# GO_process	GO:0015825	L-serine transport; ISS:HGNC.
# GO_process	GO:1904219	positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity; ISS:BHF-UCL.
# GO_process	GO:1904222	positive regulation of serine C-palmitoyltransferase activity; ISS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# Genevisible	Q9NRX5	HS
# HGNC	HGNC:13464	SERINC1
# INTERACTION	SERC1_HUMAN	Q06710 PAX8; NbExp=2; IntAct=EBI-2683145, EBI-2683132; 
# IntAct	Q9NRX5	14
# InterPro	IPR005016	TDE1/TMS
# InterPro	IPR029552	SERINC1
# MIM	614548	gene
# Organism	SERC1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10383	PTHR10383
# PANTHER	PTHR10383:SF15	PTHR10383:SF15
# Pfam	PF03348	Serinc
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-977347	Serine biosynthesis
# RecName	SERC1_HUMAN	Serine incorporator 1
# RefSeq	NP_065806	NM_020755.3
# SEQUENCE CAUTION	Sequence=BAA86567.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the TDE1 family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	SERC1_HUMAN	Endoplasmic reticulum membrane {ECO 0000250|UniProtKB Q7TNK0}; Multi-pass membrane protein {ECO 0000250|UniProtKB Q7TNK0}. 
# SUBUNIT	Interacts with SPTLC1. {ECO:0000250|UniProtKB	Q7TNK0}. 
# UCSC	uc003pyy	human
# eggNOG	ENOG410XP7K	LUCA
# eggNOG	KOG2592	Eukaryota
BLAST	swissprot:SERC1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SERC1_HUMAN
BioCyc	ZFISH:ENSG00000111897-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000111897-MONOMER
COXPRESdb	57515	http://coxpresdb.jp/data/gene/57515.shtml
CleanEx	HS_SERINC1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SERINC1
DOI	10.1002/pmic.200900783	http://dx.doi.org/10.1002/pmic.200900783
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.160270997	http://dx.doi.org/10.1073/pnas.160270997
DOI	10.1093/dnares/6.5.337	http://dx.doi.org/10.1093/dnares/6.5.337
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AB033079	http://www.ebi.ac.uk/ena/data/view/AB033079
EMBL	AF087902	http://www.ebi.ac.uk/ena/data/view/AF087902
EMBL	AF092436	http://www.ebi.ac.uk/ena/data/view/AF092436
EMBL	AF164794	http://www.ebi.ac.uk/ena/data/view/AF164794
EMBL	AK128781	http://www.ebi.ac.uk/ena/data/view/AK128781
EMBL	AL137261	http://www.ebi.ac.uk/ena/data/view/AL137261
EMBL	AY358429	http://www.ebi.ac.uk/ena/data/view/AY358429
EMBL	BC028607	http://www.ebi.ac.uk/ena/data/view/BC028607
EMBL	BC033029	http://www.ebi.ac.uk/ena/data/view/BC033029
EMBL	CH471051	http://www.ebi.ac.uk/ena/data/view/CH471051
EMBL	CH471051	http://www.ebi.ac.uk/ena/data/view/CH471051
EMBL	Z99129	http://www.ebi.ac.uk/ena/data/view/Z99129
Ensembl	ENST00000339697	http://www.ensembl.org/id/ENST00000339697
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0015194	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015194
GO_process	GO:0006658	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006658
GO_process	GO:0006665	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006665
GO_process	GO:0008654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008654
GO_process	GO:0015825	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015825
GO_process	GO:1904219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1904219
GO_process	GO:1904222	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1904222
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GeneCards	SERINC1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SERINC1
GeneID	57515	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57515
GeneTree	ENSGT00550000074522	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074522
HGNC	HGNC:13464	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13464
HOVERGEN	HBG025699	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG025699&db=HOVERGEN
HPA	HPA035738	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035738
HPA	HPA035739	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035739
InParanoid	Q9NRX5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NRX5
IntAct	Q9NRX5	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NRX5*
InterPro	IPR005016	http://www.ebi.ac.uk/interpro/entry/IPR005016
InterPro	IPR029552	http://www.ebi.ac.uk/interpro/entry/IPR029552
Jabion	57515	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=57515
KEGG_Gene	hsa:57515	http://www.genome.jp/dbget-bin/www_bget?hsa:57515
MIM	614548	http://www.ncbi.nlm.nih.gov/omim/614548
MINT	MINT-5005668	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5005668
OMA	SSSWICI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SSSWICI
OrthoDB	EOG091G07WS	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07WS
PANTHER	PTHR10383	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10383
PANTHER	PTHR10383:SF15	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10383:SF15
PSORT	swissprot:SERC1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SERC1_HUMAN
PSORT-B	swissprot:SERC1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SERC1_HUMAN
PSORT2	swissprot:SERC1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SERC1_HUMAN
Pfam	PF03348	http://pfam.xfam.org/family/PF03348
PharmGKB	PA134973249	http://www.pharmgkb.org/do/serve?objId=PA134973249&objCls=Gene
Phobius	swissprot:SERC1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SERC1_HUMAN
PhylomeDB	Q9NRX5	http://phylomedb.org/?seqid=Q9NRX5
ProteinModelPortal	Q9NRX5	http://www.proteinmodelportal.org/query/uniprot/Q9NRX5
PubMed	10574462	http://www.ncbi.nlm.nih.gov/pubmed/10574462
PubMed	10931946	http://www.ncbi.nlm.nih.gov/pubmed/10931946
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20213681	http://www.ncbi.nlm.nih.gov/pubmed/20213681
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
Reactome	R-HSA-977347	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-977347
RefSeq	NP_065806	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_065806
STRING	9606.ENSP00000342962	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000342962&targetmode=cogs
UCSC	uc003pyy	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003pyy&org=rat
UniGene	Hs.146668	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.146668
UniProtKB	SERC1_HUMAN	http://www.uniprot.org/uniprot/SERC1_HUMAN
UniProtKB-AC	Q9NRX5	http://www.uniprot.org/uniprot/Q9NRX5
charge	swissprot:SERC1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SERC1_HUMAN
eggNOG	ENOG410XP7K	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XP7K
eggNOG	KOG2592	http://eggnogapi.embl.de/nog_data/html/tree/KOG2592
epestfind	swissprot:SERC1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SERC1_HUMAN
garnier	swissprot:SERC1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SERC1_HUMAN
helixturnhelix	swissprot:SERC1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SERC1_HUMAN
hmoment	swissprot:SERC1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SERC1_HUMAN
iep	swissprot:SERC1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SERC1_HUMAN
inforesidue	swissprot:SERC1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SERC1_HUMAN
neXtProt	NX_Q9NRX5	http://www.nextprot.org/db/entry/NX_Q9NRX5
octanol	swissprot:SERC1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SERC1_HUMAN
pepcoil	swissprot:SERC1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SERC1_HUMAN
pepdigest	swissprot:SERC1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SERC1_HUMAN
pepinfo	swissprot:SERC1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SERC1_HUMAN
pepnet	swissprot:SERC1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SERC1_HUMAN
pepstats	swissprot:SERC1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SERC1_HUMAN
pepwheel	swissprot:SERC1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SERC1_HUMAN
pepwindow	swissprot:SERC1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SERC1_HUMAN
sigcleave	swissprot:SERC1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SERC1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S35D2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q76EJ3-1; Sequence=Displayed; Name=2; IsoId=Q76EJ3-2; Sequence=VSP_030006; Note=No experimental confirmation available.; 
# AltName	S35D2_HUMAN	Homolog of Fringe connection protein 1
# AltName	S35D2_HUMAN	SQV7-like protein
# AltName	S35D2_HUMAN	Solute carrier family 35 member D2
# AltName	S35D2_HUMAN	UDP-galactose transporter-related protein 8
# BIOPHYSICOCHEMICAL PROPERTIES	S35D2_HUMAN	Kinetic parameters  KM=8 uM for UDP-N-acetylglucosamine {ECO 0000269|PubMed 15082721}; KM=2.1 uM for UDP-glucose {ECO 0000269|PubMed 15082721}; KM=0.14 uM for GDP-mannose {ECO 0000269|PubMed 15082721}; 
# CCDS	CCDS6717	-. [Q76EJ3-1]
# CCDS	CCDS69625	-. [Q76EJ3-2]
# ChiTaRS	SLC35D2	human
# Ensembl	ENST00000253270	ENSP00000253270; ENSG00000130958. [Q76EJ3-1]
# Ensembl	ENST00000375259	ENSP00000364408; ENSG00000130958. [Q76EJ3-2]
# ExpressionAtlas	Q76EJ3	baseline and differential
# FUNCTION	S35D2_HUMAN	Antiporter transporting nucleotide sugars such as UDP-N- acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP- mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling. {ECO 0000269|PubMed 15082721, ECO 0000269|PubMed 15607426}. 
# GO_component	GO:0000139	Golgi membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005338	nucleotide-sugar transmembrane transporter activity; NAS:UniProtKB.
# GO_function	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0006024	glycosaminoglycan biosynthetic process; TAS:Reactome.
# GO_process	GO:0008643	carbohydrate transport; IEA:UniProtKB-KW.
# GO_process	GO:0018146	keratan sulfate biosynthetic process; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006790	sulfur compound metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0044281	small molecule metabolic process
# Genevisible	Q76EJ3	HS
# HGNC	HGNC:20799	SLC35D2
# InterPro	IPR004853	Sugar_P_trans_dom
# KEGG_Brite	ko02001	Solute carrier family
# MIM	609182	gene
# Organism	S35D2_HUMAN	Homo sapiens (Human)
# Pfam	PF03151	TPT
# Proteomes	UP000005640	Chromosome 9
# Reactome	R-HSA-2022854	Keratan sulfate biosynthesis
# Reactome	R-HSA-2022928	HS-GAG biosynthesis
# Reactome	R-HSA-727802	Transport of nucleotide sugars
# RecName	S35D2_HUMAN	UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter
# RefSeq	NP_001273919	NM_001286990.1. [Q76EJ3-2]
# RefSeq	NP_008932	NM_007001.2. [Q76EJ3-1]
# SIMILARITY	Belongs to the TPT transporter family. SLC35D subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	S35D2_HUMAN	Golgi apparatus membrane {ECO 0000269|PubMed 15082721, ECO 0000269|PubMed 15607426}; Multi- pass membrane protein {ECO 0000269|PubMed 15082721, ECO 0000269|PubMed 15607426}. 
# TCDB	2.A.7.15	the drug/metabolite transporter (dmt) superfamily
# TISSUE SPECIFICITY	Highly expressed in heart, kidney, small intestine, placenta, lung and peripheral blood leukocyte. Weakly expressed in skeletal muscle and spleen. Not expressed in brain, colon and thymus. {ECO:0000269|PubMed	15607426}. 
# UCSC	uc004awc	human. [Q76EJ3-1]
# eggNOG	COG5070	LUCA
# eggNOG	KOG1444	Eukaryota
BLAST	swissprot:S35D2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S35D2_HUMAN
COXPRESdb	11046	http://coxpresdb.jp/data/gene/11046.shtml
CleanEx	HS_SLC35D2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC35D2
DOI	10.1016/j.ygeno.2004.09.010	http://dx.doi.org/10.1016/j.ygeno.2004.09.010
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1073/pnas.96.3.974	http://dx.doi.org/10.1073/pnas.96.3.974
DOI	10.1074/jbc.M311353200	http://dx.doi.org/10.1074/jbc.M311353200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB106537	http://www.ebi.ac.uk/ena/data/view/AB106537
EMBL	AB122077	http://www.ebi.ac.uk/ena/data/view/AB122077
EMBL	AJ005866	http://www.ebi.ac.uk/ena/data/view/AJ005866
EMBL	AL160269	http://www.ebi.ac.uk/ena/data/view/AL160269
EMBL	BC009413	http://www.ebi.ac.uk/ena/data/view/BC009413
EMBL	BC100278	http://www.ebi.ac.uk/ena/data/view/BC100278
EMBL	BC113579	http://www.ebi.ac.uk/ena/data/view/BC113579
EMBL	CH471174	http://www.ebi.ac.uk/ena/data/view/CH471174
Ensembl	ENST00000253270	http://www.ensembl.org/id/ENST00000253270
Ensembl	ENST00000375259	http://www.ensembl.org/id/ENST00000375259
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005338	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005338
GO_function	GO:0015165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015165
GO_process	GO:0006024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006024
GO_process	GO:0008643	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008643
GO_process	GO:0018146	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018146
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GeneCards	SLC35D2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC35D2
GeneID	11046	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11046
GeneTree	ENSGT00390000014204	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000014204
HGNC	HGNC:20799	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20799
HOGENOM	HOG000038339	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000038339&db=HOGENOM6
HOVERGEN	HBG054071	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054071&db=HOVERGEN
HPA	HPA064047	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA064047
InParanoid	Q76EJ3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q76EJ3
InterPro	IPR004853	http://www.ebi.ac.uk/interpro/entry/IPR004853
Jabion	11046	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=11046
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:11046	http://www.genome.jp/dbget-bin/www_bget?hsa:11046
KEGG_Orthology	KO:K15281	http://www.genome.jp/dbget-bin/www_bget?KO:K15281
MIM	609182	http://www.ncbi.nlm.nih.gov/omim/609182
OMA	TYGFPSP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TYGFPSP
OrthoDB	EOG091G0KCU	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0KCU
PSORT	swissprot:S35D2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S35D2_HUMAN
PSORT-B	swissprot:S35D2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S35D2_HUMAN
PSORT2	swissprot:S35D2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S35D2_HUMAN
Pfam	PF03151	http://pfam.xfam.org/family/PF03151
PharmGKB	PA134909604	http://www.pharmgkb.org/do/serve?objId=PA134909604&objCls=Gene
Phobius	swissprot:S35D2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S35D2_HUMAN
PhylomeDB	Q76EJ3	http://phylomedb.org/?seqid=Q76EJ3
ProteinModelPortal	Q76EJ3	http://www.proteinmodelportal.org/query/uniprot/Q76EJ3
PubMed	15082721	http://www.ncbi.nlm.nih.gov/pubmed/15082721
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15607426	http://www.ncbi.nlm.nih.gov/pubmed/15607426
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	9927678	http://www.ncbi.nlm.nih.gov/pubmed/9927678
Reactome	R-HSA-2022854	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2022854
Reactome	R-HSA-2022928	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2022928
Reactome	R-HSA-727802	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-727802
RefSeq	NP_001273919	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273919
RefSeq	NP_008932	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_008932
STRING	9606.ENSP00000253270	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000253270&targetmode=cogs
TCDB	2.A.7.15	http://www.tcdb.org/search/result.php?tc=2.A.7.15
UCSC	uc004awc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004awc&org=rat
UniGene	Hs.494556	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.494556
UniGene	Hs.731624	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.731624
UniProtKB	S35D2_HUMAN	http://www.uniprot.org/uniprot/S35D2_HUMAN
UniProtKB-AC	Q76EJ3	http://www.uniprot.org/uniprot/Q76EJ3
charge	swissprot:S35D2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S35D2_HUMAN
eggNOG	COG5070	http://eggnogapi.embl.de/nog_data/html/tree/COG5070
eggNOG	KOG1444	http://eggnogapi.embl.de/nog_data/html/tree/KOG1444
epestfind	swissprot:S35D2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S35D2_HUMAN
garnier	swissprot:S35D2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S35D2_HUMAN
helixturnhelix	swissprot:S35D2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S35D2_HUMAN
hmoment	swissprot:S35D2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S35D2_HUMAN
iep	swissprot:S35D2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S35D2_HUMAN
inforesidue	swissprot:S35D2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S35D2_HUMAN
neXtProt	NX_Q76EJ3	http://www.nextprot.org/db/entry/NX_Q76EJ3
octanol	swissprot:S35D2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S35D2_HUMAN
pepcoil	swissprot:S35D2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S35D2_HUMAN
pepdigest	swissprot:S35D2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S35D2_HUMAN
pepinfo	swissprot:S35D2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S35D2_HUMAN
pepnet	swissprot:S35D2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S35D2_HUMAN
pepstats	swissprot:S35D2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S35D2_HUMAN
pepwheel	swissprot:S35D2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S35D2_HUMAN
pepwindow	swissprot:S35D2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S35D2_HUMAN
sigcleave	swissprot:S35D2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S35D2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CTL4_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q53GD3-1; Sequence=Displayed; Name=2; IsoId=Q53GD3-2; Sequence=VSP_030998; Note=No experimental confirmation available.; Name=3; IsoId=Q53GD3-3; Sequence=VSP_046236; Note=No experimental confirmation available.; Name=4; IsoId=Q53GD3-4; Sequence=VSP_046821; 
# AltName	CTL4_HUMAN	Solute carrier family 44 member 4
# CCDS	CCDS4724	-. [Q53GD3-1]
# CCDS	CCDS54989	-. [Q53GD3-3]
# CCDS	CCDS54990	-. [Q53GD3-4]
# ChiTaRS	SLC44A4	human
# DISEASE	CTL4_HUMAN	Note=An interstitial deletion causing the fusion of exon 10 of CTL4 with the 3'-UTR of NEU has been detected in two patients affected by sialidosis. 
# DrugBank	DB00122	Choline
# Ensembl	ENST00000229729	ENSP00000229729; ENSG00000204385. [Q53GD3-1]
# Ensembl	ENST00000375562	ENSP00000364712; ENSG00000204385. [Q53GD3-4]
# Ensembl	ENST00000383379	ENSP00000372870; ENSG00000206378. [Q53GD3-1]
# Ensembl	ENST00000415517	ENSP00000414120; ENSG00000229077
# Ensembl	ENST00000417894	ENSP00000389244; ENSG00000235336
# Ensembl	ENST00000425238	ENSP00000399161; ENSG00000228263. [Q53GD3-1]
# Ensembl	ENST00000442152	ENSP00000398852; ENSG00000232180
# Ensembl	ENST00000453831	ENSP00000393939; ENSG00000231479. [Q53GD3-1]
# Ensembl	ENST00000544672	ENSP00000444109; ENSG00000204385. [Q53GD3-3]
# Ensembl	ENST00000546461	ENSP00000449039; ENSG00000231479. [Q53GD3-3]
# Ensembl	ENST00000547493	ENSP00000449232; ENSG00000229077
# Ensembl	ENST00000547684	ENSP00000449180; ENSG00000206378. [Q53GD3-3]
# Ensembl	ENST00000548188	ENSP00000447560; ENSG00000228263. [Q53GD3-3]
# Ensembl	ENST00000549663	ENSP00000449642; ENSG00000228263. [Q53GD3-4]
# Ensembl	ENST00000549677	ENSP00000449518; ENSG00000206378. [Q53GD3-4]
# Ensembl	ENST00000550401	ENSP00000448474; ENSG00000235336
# Ensembl	ENST00000551168	ENSP00000448088; ENSG00000231479. [Q53GD3-4]
# Ensembl	ENST00000553121	ENSP00000447704; ENSG00000232180
# ExpressionAtlas	Q53GD3	baseline and differential
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0015220	choline transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0006656	phosphatidylcholine biosynthetic process; TAS:Reactome.
# GO_process	GO:0008292	acetylcholine biosynthetic process; IMP:UniProtKB.
# GO_process	GO:0030307	positive regulation of cell growth; IMP:UniProtKB.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GO_process	GO:0061526	acetylcholine secretion; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q53GD3	HS
# HGNC	HGNC:13941	SLC44A4
# InterPro	IPR007603	Choline_transptr-like
# KEGG_Brite	ko02001	Solute carrier family
# MIM	606107	gene
# Organism	CTL4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12385	PTHR12385; 2
# Pfam	PF04515	Choline_transpo
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-1483191	Synthesis of PC
# Reactome	R-HSA-425366	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
# RecName	CTL4_HUMAN	Choline transporter-like protein 4
# RefSeq	NP_001171515	NM_001178044.1. [Q53GD3-4]
# RefSeq	NP_001171516	NM_001178045.1. [Q53GD3-3]
# RefSeq	NP_079533	NM_025257.2. [Q53GD3-1]
# SIMILARITY	Belongs to the CTL (choline transporter-like) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	CTL4_HUMAN	Membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# TCDB	2.A.92.1	the choline transporter-like (ctl) family
# UCSC	uc010jti	human. [Q53GD3-1]
# eggNOG	ENOG410XS0P	LUCA
# eggNOG	KOG1362	Eukaryota
BLAST	swissprot:CTL4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CTL4_HUMAN
BioCyc	ZFISH:ENSG00000163599-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000163599-MONOMER
BioCyc	ZFISH:HS03497-MONOMER	http://biocyc.org/getid?id=ZFISH:HS03497-MONOMER
COXPRESdb	80736	http://coxpresdb.jp/data/gene/80736.shtml
DOI	10.1016/S0014-5793(02)02748-5	http://dx.doi.org/10.1016/S0014-5793(02)02748-5
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.030339697	http://dx.doi.org/10.1073/pnas.030339697
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.1736803	http://dx.doi.org/10.1101/gr.1736803
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DrugBank	DB00122	http://www.drugbank.ca/drugs/DB00122
EMBL	AF134726	http://www.ebi.ac.uk/ena/data/view/AF134726
EMBL	AF466766	http://www.ebi.ac.uk/ena/data/view/AF466766
EMBL	AK027397	http://www.ebi.ac.uk/ena/data/view/AK027397
EMBL	AK222998	http://www.ebi.ac.uk/ena/data/view/AK222998
EMBL	AK300550	http://www.ebi.ac.uk/ena/data/view/AK300550
EMBL	AK301596	http://www.ebi.ac.uk/ena/data/view/AK301596
EMBL	AL662834	http://www.ebi.ac.uk/ena/data/view/AL662834
EMBL	AL671762	http://www.ebi.ac.uk/ena/data/view/AL671762
EMBL	AL833009	http://www.ebi.ac.uk/ena/data/view/AL833009
EMBL	AL844853	http://www.ebi.ac.uk/ena/data/view/AL844853
EMBL	AY358457	http://www.ebi.ac.uk/ena/data/view/AY358457
EMBL	BA000025	http://www.ebi.ac.uk/ena/data/view/BA000025
EMBL	BC014659	http://www.ebi.ac.uk/ena/data/view/BC014659
EMBL	BX005460	http://www.ebi.ac.uk/ena/data/view/BX005460
EMBL	CH471081	http://www.ebi.ac.uk/ena/data/view/CH471081
EMBL	CR388202	http://www.ebi.ac.uk/ena/data/view/CR388202
EMBL	CR759784	http://www.ebi.ac.uk/ena/data/view/CR759784
EMBL	CR936237	http://www.ebi.ac.uk/ena/data/view/CR936237
Ensembl	ENST00000229729	http://www.ensembl.org/id/ENST00000229729
Ensembl	ENST00000375562	http://www.ensembl.org/id/ENST00000375562
Ensembl	ENST00000383379	http://www.ensembl.org/id/ENST00000383379
Ensembl	ENST00000415517	http://www.ensembl.org/id/ENST00000415517
Ensembl	ENST00000417894	http://www.ensembl.org/id/ENST00000417894
Ensembl	ENST00000425238	http://www.ensembl.org/id/ENST00000425238
Ensembl	ENST00000442152	http://www.ensembl.org/id/ENST00000442152
Ensembl	ENST00000453831	http://www.ensembl.org/id/ENST00000453831
Ensembl	ENST00000544672	http://www.ensembl.org/id/ENST00000544672
Ensembl	ENST00000546461	http://www.ensembl.org/id/ENST00000546461
Ensembl	ENST00000547493	http://www.ensembl.org/id/ENST00000547493
Ensembl	ENST00000547684	http://www.ensembl.org/id/ENST00000547684
Ensembl	ENST00000548188	http://www.ensembl.org/id/ENST00000548188
Ensembl	ENST00000549663	http://www.ensembl.org/id/ENST00000549663
Ensembl	ENST00000549677	http://www.ensembl.org/id/ENST00000549677
Ensembl	ENST00000550401	http://www.ensembl.org/id/ENST00000550401
Ensembl	ENST00000551168	http://www.ensembl.org/id/ENST00000551168
Ensembl	ENST00000553121	http://www.ensembl.org/id/ENST00000553121
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0015220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015220
GO_process	GO:0006656	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006656
GO_process	GO:0008292	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008292
GO_process	GO:0030307	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030307
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GO_process	GO:0061526	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061526
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC44A4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC44A4
GeneID	80736	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80736
GeneTree	ENSGT00550000074521	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074521
H-InvDB	HIX0166072	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0166072
H-InvDB	HIX0166339	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0166339
H-InvDB	HIX0167126	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0167126
H-InvDB	HIX0184154	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0184154
HGNC	HGNC:13941	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13941
HOGENOM	HOG000007110	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007110&db=HOGENOM6
HOVERGEN	HBG062155	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG062155&db=HOVERGEN
HPA	HPA046977	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA046977
HPA	HPA054176	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA054176
InParanoid	Q53GD3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q53GD3
InterPro	IPR007603	http://www.ebi.ac.uk/interpro/entry/IPR007603
Jabion	80736	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=80736
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:80736	http://www.genome.jp/dbget-bin/www_bget?hsa:80736
KEGG_Orthology	KO:K15377	http://www.genome.jp/dbget-bin/www_bget?KO:K15377
MIM	606107	http://www.ncbi.nlm.nih.gov/omim/606107
OMA	KNVLQNQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KNVLQNQ
OrthoDB	EOG091G04CQ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G04CQ
PANTHER	PTHR12385	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12385
PSORT	swissprot:CTL4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CTL4_HUMAN
PSORT-B	swissprot:CTL4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CTL4_HUMAN
PSORT2	swissprot:CTL4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CTL4_HUMAN
Pfam	PF04515	http://pfam.xfam.org/family/PF04515
PharmGKB	PA25930	http://www.pharmgkb.org/do/serve?objId=PA25930&objCls=Gene
Phobius	swissprot:CTL4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CTL4_HUMAN
PhylomeDB	Q53GD3	http://phylomedb.org/?seqid=Q53GD3
ProteinModelPortal	Q53GD3	http://www.proteinmodelportal.org/query/uniprot/Q53GD3
PubMed	10677542	http://www.ncbi.nlm.nih.gov/pubmed/10677542
PubMed	12067718	http://www.ncbi.nlm.nih.gov/pubmed/12067718
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14656967	http://www.ncbi.nlm.nih.gov/pubmed/14656967
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
Reactome	R-HSA-1483191	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1483191
Reactome	R-HSA-425366	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425366
RefSeq	NP_001171515	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001171515
RefSeq	NP_001171516	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001171516
RefSeq	NP_079533	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_079533
STRING	9606.ENSP00000229729	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000229729&targetmode=cogs
TCDB	2.A.92.1	http://www.tcdb.org/search/result.php?tc=2.A.92.1
UCSC	uc010jti	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010jti&org=rat
UniGene	Hs.335355	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.335355
UniProtKB	CTL4_HUMAN	http://www.uniprot.org/uniprot/CTL4_HUMAN
UniProtKB-AC	Q53GD3	http://www.uniprot.org/uniprot/Q53GD3
charge	swissprot:CTL4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CTL4_HUMAN
eggNOG	ENOG410XS0P	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS0P
eggNOG	KOG1362	http://eggnogapi.embl.de/nog_data/html/tree/KOG1362
epestfind	swissprot:CTL4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CTL4_HUMAN
garnier	swissprot:CTL4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CTL4_HUMAN
helixturnhelix	swissprot:CTL4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CTL4_HUMAN
hmoment	swissprot:CTL4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CTL4_HUMAN
iep	swissprot:CTL4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CTL4_HUMAN
inforesidue	swissprot:CTL4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CTL4_HUMAN
neXtProt	NX_Q53GD3	http://www.nextprot.org/db/entry/NX_Q53GD3
octanol	swissprot:CTL4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CTL4_HUMAN
pepcoil	swissprot:CTL4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CTL4_HUMAN
pepdigest	swissprot:CTL4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CTL4_HUMAN
pepinfo	swissprot:CTL4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CTL4_HUMAN
pepnet	swissprot:CTL4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CTL4_HUMAN
pepstats	swissprot:CTL4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CTL4_HUMAN
pepwheel	swissprot:CTL4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CTL4_HUMAN
pepwindow	swissprot:CTL4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CTL4_HUMAN
sigcleave	swissprot:CTL4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CTL4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ANO7_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=NGEP-L; IsoId=Q6IWH7-1; Sequence=Displayed; Name=2; Synonyms=NGEP-S; IsoId=Q6IWH7-2; Sequence=VSP_026004, VSP_026005, VSP_026006; Name=3; Synonyms=D-TMPP; IsoId=Q6IWH7-3; Sequence=VSP_026004, VSP_026007, VSP_026008; 
# AltName	ANO7_HUMAN	Dresden transmembrane protein of the prostate
# AltName	ANO7_HUMAN	IPCA-5
# AltName	ANO7_HUMAN	New gene expressed in prostate
# AltName	ANO7_HUMAN	Prostate cancer-associated protein 5
# AltName	ANO7_HUMAN	Transmembrane protein 16G
# CAUTION	It is uncertain whether Met-1 or Met-55 is the initiator. {ECO	0000305}.
# CCDS	CCDS33423	-. [Q6IWH7-1]
# CCDS	CCDS46563	-. [Q6IWH7-2]
# Ensembl	ENST00000274979	ENSP00000274979; ENSG00000146205. [Q6IWH7-1]
# Ensembl	ENST00000402430	ENSP00000385418; ENSG00000146205. [Q6IWH7-3]
# Ensembl	ENST00000402530	ENSP00000383985; ENSG00000146205. [Q6IWH7-2]
# ExpressionAtlas	Q6IWH7	baseline and differential
# FUNCTION	ANO7_HUMAN	Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium- activated chloride channel (CaCC) activity. May play a role in cell-cell interactions. {ECO 0000250|UniProtKB Q14AT5, ECO 0000269|PubMed 17308099}. 
# GO_component	GO:0005622	intracellular; IDA:UniProtKB.
# GO_component	GO:0005634	nucleus; IEA:Ensembl.
# GO_component	GO:0005783	endoplasmic reticulum; IDA:UniProtKB.
# GO_component	GO:0005829	cytosol; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-SubCell.
# GO_function	GO:0005229	intracellular calcium activated chloride channel activity; IDA:UniProtKB.
# GO_function	GO:0017128	phospholipid scramblase activity; IEA:Ensembl.
# GO_process	GO:0006821	chloride transport; IDA:UniProtKB.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0061589	calcium activated phosphatidylserine scrambling; IEA:Ensembl.
# GO_process	GO:0061590	calcium activated phosphatidylcholine scrambling; IEA:Ensembl.
# GO_process	GO:0061591	calcium activated galactosylceramide scrambling; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005622	intracellular
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007009	plasma membrane organization
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q6IWH7	HS
# HGNC	HGNC:31677	ANO7
# INDUCTION	Up-regulated by androgen. {ECO:0000269|PubMed	15761874}. 
# InterPro	IPR007632	Anoctamin
# InterPro	IPR031296	Anoctamin-7
# InterPro	IPR032394	Anoct_dimer
# MIM	605096	gene
# MISCELLANEOUS	ANO7_HUMAN	The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology. 
# Organism	ANO7_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12308	PTHR12308
# PANTHER	PTHR12308:SF22	PTHR12308:SF22
# Pfam	PF04547	Anoctamin
# Pfam	PF16178	Anoct_dimer
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	ANO7_HUMAN	Anoctamin-7
# RefSeq	NP_001001666	NM_001001666.3. [Q6IWH7-2]
# RefSeq	NP_001001891	NM_001001891.3. [Q6IWH7-1]
# SIMILARITY	Belongs to the anoctamin family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	ANO7_HUMAN	Isoform 1  Cell membrane {ECO 0000269|PubMed 14981236, ECO 0000269|PubMed 17308099, ECO 0000269|PubMed 20056604, ECO 0000269|PubMed 22946059}; Multi- pass membrane protein {ECO 0000255}. Cell junction {ECO 0000269|PubMed 17308099}. Endoplasmic reticulum {ECO 0000269|PubMed 22075693}. Note=Concentrates at sites of cell- cell contact (PubMed 17308099). Shows an intracellular localization according to PubMed 22075693 and PubMed 20056604. {ECO 0000269|PubMed 17308099, ECO 0000269|PubMed 20056604, ECO 0000269|PubMed 22075693}. 
# SUBCELLULAR LOCATION	ANO7_HUMAN	Isoform 2  Cytoplasm, cytosol {ECO 0000269|PubMed 14981236}. 
# TISSUE SPECIFICITY	ANO7_HUMAN	Specifically expressed in epithelial cells of the prostate (at protein level). {ECO 0000269|PubMed 14981236, ECO 0000269|PubMed 15761874, ECO 0000269|PubMed 17308099}. 
# UCSC	uc002waw	human. [Q6IWH7-1]
# eggNOG	ENOG410XS4S	LUCA
# eggNOG	KOG2514	Eukaryota
BLAST	swissprot:ANO7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ANO7_HUMAN
COXPRESdb	50636	http://coxpresdb.jp/data/gene/50636.shtml
CleanEx	HS_ANO7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ANO7
DOI	10.1002/pros.20250	http://dx.doi.org/10.1002/pros.20250
DOI	10.1007/s00424-011-0975-9	http://dx.doi.org/10.1007/s00424-011-0975-9
DOI	10.1038/aps.2011.48	http://dx.doi.org/10.1038/aps.2011.48
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1073/pnas.0308746101	http://dx.doi.org/10.1073/pnas.0308746101
DOI	10.1074/jbc.M109.065367	http://dx.doi.org/10.1074/jbc.M109.065367
DOI	10.1101/gr.9.12.1198	http://dx.doi.org/10.1101/gr.9.12.1198
DOI	10.1113/expphysiol.2011.058198	http://dx.doi.org/10.1113/expphysiol.2011.058198
DOI	10.1113/expphysiol.2011.058214	http://dx.doi.org/10.1113/expphysiol.2011.058214
DOI	10.1152/ajpcell.00140.2011	http://dx.doi.org/10.1152/ajpcell.00140.2011
DOI	10.1158/0008-5472.CAN-06-2673	http://dx.doi.org/10.1158/0008-5472.CAN-06-2673
DOI	10.1158/0008-5472.CAN-08-0870	http://dx.doi.org/10.1158/0008-5472.CAN-08-0870
DOI	10.1242/jcs.109553	http://dx.doi.org/10.1242/jcs.109553
EMBL	AC005237	http://www.ebi.ac.uk/ena/data/view/AC005237
EMBL	AC104841	http://www.ebi.ac.uk/ena/data/view/AC104841
EMBL	AC111201	http://www.ebi.ac.uk/ena/data/view/AC111201
EMBL	AY617079	http://www.ebi.ac.uk/ena/data/view/AY617079
EMBL	AY617080	http://www.ebi.ac.uk/ena/data/view/AY617080
Ensembl	ENST00000274979	http://www.ensembl.org/id/ENST00000274979
Ensembl	ENST00000402430	http://www.ensembl.org/id/ENST00000402430
Ensembl	ENST00000402530	http://www.ensembl.org/id/ENST00000402530
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_function	GO:0005229	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005229
GO_function	GO:0017128	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017128
GO_process	GO:0006821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006821
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0061589	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061589
GO_process	GO:0061590	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061590
GO_process	GO:0061591	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061591
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007009
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ANO7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ANO7
GeneID	50636	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=50636
GeneTree	ENSGT00760000119015	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119015
HGNC	HGNC:31677	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:31677
HOGENOM	HOG000006509	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006509&db=HOGENOM6
HOVERGEN	HBG069519	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG069519&db=HOVERGEN
HPA	HPA035730	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035730
InParanoid	Q6IWH7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6IWH7
InterPro	IPR007632	http://www.ebi.ac.uk/interpro/entry/IPR007632
InterPro	IPR031296	http://www.ebi.ac.uk/interpro/entry/IPR031296
InterPro	IPR032394	http://www.ebi.ac.uk/interpro/entry/IPR032394
Jabion	50636	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=50636
KEGG_Gene	hsa:50636	http://www.genome.jp/dbget-bin/www_bget?hsa:50636
MIM	605096	http://www.ncbi.nlm.nih.gov/omim/605096
OMA	PLCLDCP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PLCLDCP
OrthoDB	EOG091G01JF	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01JF
PANTHER	PTHR12308	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12308
PANTHER	PTHR12308:SF22	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12308:SF22
PSORT	swissprot:ANO7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ANO7_HUMAN
PSORT-B	swissprot:ANO7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ANO7_HUMAN
PSORT2	swissprot:ANO7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ANO7_HUMAN
Pfam	PF04547	http://pfam.xfam.org/family/PF04547
Pfam	PF16178	http://pfam.xfam.org/family/PF16178
PharmGKB	PA32980	http://www.pharmgkb.org/do/serve?objId=PA32980&objCls=Gene
Phobius	swissprot:ANO7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ANO7_HUMAN
PhylomeDB	Q6IWH7	http://phylomedb.org/?seqid=Q6IWH7
ProteinModelPortal	Q6IWH7	http://www.proteinmodelportal.org/query/uniprot/Q6IWH7
PubMed	10613842	http://www.ncbi.nlm.nih.gov/pubmed/10613842
PubMed	14981236	http://www.ncbi.nlm.nih.gov/pubmed/14981236
PubMed	15375614	http://www.ncbi.nlm.nih.gov/pubmed/15375614
PubMed	15761874	http://www.ncbi.nlm.nih.gov/pubmed/15761874
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	17308099	http://www.ncbi.nlm.nih.gov/pubmed/17308099
PubMed	18676855	http://www.ncbi.nlm.nih.gov/pubmed/18676855
PubMed	20056604	http://www.ncbi.nlm.nih.gov/pubmed/20056604
PubMed	21607626	http://www.ncbi.nlm.nih.gov/pubmed/21607626
PubMed	21642943	http://www.ncbi.nlm.nih.gov/pubmed/21642943
PubMed	21984732	http://www.ncbi.nlm.nih.gov/pubmed/21984732
PubMed	22075693	http://www.ncbi.nlm.nih.gov/pubmed/22075693
PubMed	22302790	http://www.ncbi.nlm.nih.gov/pubmed/22302790
PubMed	22946059	http://www.ncbi.nlm.nih.gov/pubmed/22946059
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_001001666	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001001666
RefSeq	NP_001001891	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001001891
STRING	9606.ENSP00000274979	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000274979&targetmode=cogs
UCSC	uc002waw	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002waw&org=rat
UniGene	Hs.163909	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.163909
UniProtKB	ANO7_HUMAN	http://www.uniprot.org/uniprot/ANO7_HUMAN
UniProtKB-AC	Q6IWH7	http://www.uniprot.org/uniprot/Q6IWH7
charge	swissprot:ANO7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ANO7_HUMAN
eggNOG	ENOG410XS4S	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS4S
eggNOG	KOG2514	http://eggnogapi.embl.de/nog_data/html/tree/KOG2514
epestfind	swissprot:ANO7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ANO7_HUMAN
garnier	swissprot:ANO7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ANO7_HUMAN
helixturnhelix	swissprot:ANO7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ANO7_HUMAN
hmoment	swissprot:ANO7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ANO7_HUMAN
iep	swissprot:ANO7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ANO7_HUMAN
inforesidue	swissprot:ANO7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ANO7_HUMAN
neXtProt	NX_Q6IWH7	http://www.nextprot.org/db/entry/NX_Q6IWH7
octanol	swissprot:ANO7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ANO7_HUMAN
pepcoil	swissprot:ANO7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ANO7_HUMAN
pepdigest	swissprot:ANO7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ANO7_HUMAN
pepinfo	swissprot:ANO7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ANO7_HUMAN
pepnet	swissprot:ANO7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ANO7_HUMAN
pepstats	swissprot:ANO7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ANO7_HUMAN
pepwheel	swissprot:ANO7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ANO7_HUMAN
pepwindow	swissprot:ANO7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ANO7_HUMAN
sigcleave	swissprot:ANO7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ANO7_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TPSN_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=O15533-1; Sequence=Displayed; Name=2; IsoId=O15533-2; Sequence=VSP_002577; Note=Due to a partial intron retention.; Name=3; IsoId=O15533-3; Sequence=VSP_017055; Note=No experimental confirmation available.; Name=4; Synonyms=tpsnDeltaEx3; IsoId=O15533-4; Sequence=VSP_044455; 
# AltName	TPSN_HUMAN	NGS-17
# AltName	TPSN_HUMAN	TAP-associated protein
# AltName	TPSN_HUMAN	TAP-binding protein
# BioGrid	112755	14
# CCDS	CCDS34426	-. [O15533-1]
# CCDS	CCDS34427	-. [O15533-4]
# CCDS	CCDS34428	-. [O15533-3]
# ChiTaRS	TAPBP	human
# DISEASE	TPSN_HUMAN	Bare lymphocyte syndrome 1 (BLS1) [MIM 604571]  A HLA class I deficiency. Contrary to bare lymphocyte syndromes type 2 and type 3, which are characterized by early-onset severe combined immunodeficiency, class I antigen deficiencies are not accompanied by particular pathologic manifestations during the first years of life. Systemic infections have not been described. Chronic bacterial infections, often beginning in the first decade of life, are restricted to the respiratory tract. {ECO 0000269|PubMed 12149238}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	TPSN_HUMAN	The N-terminus is required for efficient association with MHC class I molecule and for a stable interaction between MHC I and calreticulin. Binding to TAP is mediated by the C-terminal region. {ECO 0000269|PubMed 10382748}. 
# Ensembl	ENST00000374572	ENSP00000363700; ENSG00000112493. [O15533-1]
# Ensembl	ENST00000383066	ENSP00000372543; ENSG00000206208
# Ensembl	ENST00000383197	ENSP00000372684; ENSG00000206281. [O15533-3]
# Ensembl	ENST00000383198	ENSP00000372685; ENSG00000206281. [O15533-1]
# Ensembl	ENST00000395114	ENSP00000378546; ENSG00000112493. [O15533-3]
# Ensembl	ENST00000417059	ENSP00000402087; ENSG00000236490. [O15533-1]
# Ensembl	ENST00000434618	ENSP00000395701; ENSG00000231925
# Ensembl	ENST00000456807	ENSP00000407195; ENSG00000236490. [O15533-3]
# ExpressionAtlas	O15533	baseline and differential
# FUNCTION	TPSN_HUMAN	Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). {ECO 0000269|PubMed 10636848}. 
# GO_component	GO:0000139	Golgi membrane; IDA:UniProtKB.
# GO_component	GO:0005783	endoplasmic reticulum; TAS:ProtInc.
# GO_component	GO:0005789	endoplasmic reticulum membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_component	GO:0042824	MHC class I peptide loading complex; NAS:UniProtKB.
# GO_component	GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome.
# GO_function	GO:0015433	peptide antigen-transporting ATPase activity; TAS:ProtInc.
# GO_function	GO:0042288	MHC class I protein binding; TAS:UniProtKB.
# GO_function	GO:0042605	peptide antigen binding; TAS:UniProtKB.
# GO_function	GO:0046978	TAP1 binding; IPI:UniProtKB.
# GO_function	GO:0046979	TAP2 binding; IPI:UniProtKB.
# GO_function	GO:0051082	unfolded protein binding; TAS:UniProtKB.
# GO_process	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome.
# GO_process	GO:0006461	protein complex assembly; TAS:ProtInc.
# GO_process	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER; NAS:UniProtKB.
# GO_process	GO:0006955	immune response; TAS:ProtInc.
# GO_process	GO:0010468	regulation of gene expression; IMP:AgBase.
# GO_process	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I; IEA:InterPro.
# GO_process	GO:0050823	peptide antigen stabilization; ISS:UniProtKB.
# GO_process	GO:0061635	regulation of protein complex stability; IDA:AgBase.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0051082	unfolded protein binding
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# Gene3D	2.60.40.10	-; 1.
# Genevisible	O15533	HS
# HGNC	HGNC:11566	TAPBP
# INTERACTION	TPSN_HUMAN	P0C739 BNLF2a (xeno); NbExp=6; IntAct=EBI-874801, EBI-9346744; Q77CE4 gN (xeno); NbExp=2; IntAct=EBI-874801, EBI-11303846; Q03518 TAP1; NbExp=14; IntAct=EBI-874801, EBI-747259; Q03519 TAP2; NbExp=8; IntAct=EBI-874801, EBI-780781; 
# IntAct	O15533	12
# InterPro	IPR003597	Ig_C1-set
# InterPro	IPR007110	Ig-like_dom
# InterPro	IPR008056	Tapasin
# InterPro	IPR013783	Ig-like_fold
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Disease	H00984	[Inherited metabolic disease; Immune system disease] Bare lymphocyte syndrome (BLS) type1
# KEGG_Pathway	ko04612	Antigen processing and presentation
# MIM	601962	gene
# MIM	604571	phenotype
# Organism	TPSN_HUMAN	Homo sapiens (Human)
# Orphanet	34592	Immunodeficiency by defective expression of HLA class 1
# PDB	3F8U	X-ray; 2.60 A; B/D=1-401
# POLYMORPHISM	The 2 alleles of TAPBP; TAPBP*01 (Tapasin*01) (shown here) and TAPBP*02 (Tapasin*02); are in linkage disequilibria with the HLA-DRB1 locus in a Japanese population. {ECO:0000269|PubMed	9802609}. 
# PRINTS	PR01669	TAPASIN
# PROSITE	PS50835	IG_LIKE
# Pfam	PF07654	C1-set
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-1236974	ER-Phagosome pathway
# Reactome	R-HSA-983170:Antigen Presentation	 Folding, assembly and peptide loading of class I MHC
# RecName	TPSN_HUMAN	Tapasin
# RefSeq	NP_003181	NM_003190.4
# RefSeq	NP_757345	NM_172208.2
# RefSeq	NP_757346	NM_172209.2
# SEQUENCE CAUTION	Sequence=AAD32924.2; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO	0000305}; 
# SIMILARITY	Contains 1 Ig-like C1-type (immunoglobulin-like) domain. {ECO	0000305}. 
# SUBCELLULAR LOCATION	TPSN_HUMAN	Endoplasmic reticulum membrane {ECO 0000305}; Single-pass type I membrane protein {ECO 0000305}. 
# SUBUNIT	Heterodimer with PDIA3; disulfide-linked. Interacts with TAP1 and is thus a subunit of the TAP complex, also known as the peptide loading complex (PLC). Interaction with TAP1 is TAP2- independent and is required for efficient peptide-TAP interaction. Obligatory mediator for the interaction between newly assembled MHC class I molecules, calreticulin, PDIA3 and TAP. Up to 4 MHC class I/tapasin complexes bind to 1 TAP. {ECO:0000269|PubMed	19119025}. 
# SUPFAM	SSF48726	SSF48726
# TISSUE SPECIFICITY	TPSN_HUMAN	Neutrophils, mostly in fully differentiated cells. 
# TopDownProteomics	O15533-3	-. [O15533-3]
# UCSC	uc003odx	human. [O15533-1]
# WEB RESOURCE	TPSN_HUMAN	Name=TAPBPbase; Note=TAPBP mutation db; URL="http //structure.bmc.lu.se/idbase/TAPBPbase/";
# eggNOG	ENOG410II43	Eukaryota
# eggNOG	ENOG4111QPK	LUCA
BLAST	swissprot:TPSN_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TPSN_HUMAN
BioCyc	ZFISH:ENSG00000112493-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000112493-MONOMER
COXPRESdb	6892	http://coxpresdb.jp/data/gene/6892.shtml
DOI	10.1002/(SICI)1521-4141(199802)28:02<459::AID-IMMU459>3.0.CO	http://dx.doi.org/10.1002/(SICI)1521-4141(199802)28:02<459::AID-IMMU459>3.0.CO
DOI	10.1002/(SICI)1521-4141(199906)29:06<1858::AID-IMMU1858>3.0.CO	http://dx.doi.org/10.1002/(SICI)1521-4141(199906)29:06<1858::AID-IMMU1858>3.0.CO
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/jmbi.1998.1637	http://dx.doi.org/10.1006/jmbi.1998.1637
DOI	10.1016/j.humimm.2010.05.019	http://dx.doi.org/10.1016/j.humimm.2010.05.019
DOI	10.1016/j.immuni.2008.10.018	http://dx.doi.org/10.1016/j.immuni.2008.10.018
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/sj.gene.6364043	http://dx.doi.org/10.1038/sj.gene.6364043
DOI	10.1073/pnas.94.16.8708	http://dx.doi.org/10.1073/pnas.94.16.8708
DOI	10.1074/jbc.275.3.1581	http://dx.doi.org/10.1074/jbc.275.3.1581
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1399-0039.1998.tb03044.x	http://dx.doi.org/10.1111/j.1399-0039.1998.tb03044.x
DOI	10.1126/science.277.5330.1306	http://dx.doi.org/10.1126/science.277.5330.1306
DOI	10.1182/blood-2001-12-0252	http://dx.doi.org/10.1182/blood-2001-12-0252
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AB010639	http://www.ebi.ac.uk/ena/data/view/AB010639
EMBL	AB012622	http://www.ebi.ac.uk/ena/data/view/AB012622
EMBL	AB012920	http://www.ebi.ac.uk/ena/data/view/AB012920
EMBL	AF009510	http://www.ebi.ac.uk/ena/data/view/AF009510
EMBL	AF029750	http://www.ebi.ac.uk/ena/data/view/AF029750
EMBL	AF067286	http://www.ebi.ac.uk/ena/data/view/AF067286
EMBL	AF314222	http://www.ebi.ac.uk/ena/data/view/AF314222
EMBL	AL662820	http://www.ebi.ac.uk/ena/data/view/AL662820
EMBL	AL662827	http://www.ebi.ac.uk/ena/data/view/AL662827
EMBL	BC080574	http://www.ebi.ac.uk/ena/data/view/BC080574
EMBL	BX248088	http://www.ebi.ac.uk/ena/data/view/BX248088
EMBL	BX248088	http://www.ebi.ac.uk/ena/data/view/BX248088
EMBL	CH471081	http://www.ebi.ac.uk/ena/data/view/CH471081
EMBL	CR759786	http://www.ebi.ac.uk/ena/data/view/CR759786
EMBL	CR759786	http://www.ebi.ac.uk/ena/data/view/CR759786
EMBL	CR759817	http://www.ebi.ac.uk/ena/data/view/CR759817
EMBL	CR759817	http://www.ebi.ac.uk/ena/data/view/CR759817
EMBL	EU693375	http://www.ebi.ac.uk/ena/data/view/EU693375
EMBL	Y13582	http://www.ebi.ac.uk/ena/data/view/Y13582
EMBL	Z97183	http://www.ebi.ac.uk/ena/data/view/Z97183
EMBL	Z97184	http://www.ebi.ac.uk/ena/data/view/Z97184
Ensembl	ENST00000374572	http://www.ensembl.org/id/ENST00000374572
Ensembl	ENST00000383066	http://www.ensembl.org/id/ENST00000383066
Ensembl	ENST00000383197	http://www.ensembl.org/id/ENST00000383197
Ensembl	ENST00000383198	http://www.ensembl.org/id/ENST00000383198
Ensembl	ENST00000395114	http://www.ensembl.org/id/ENST00000395114
Ensembl	ENST00000417059	http://www.ensembl.org/id/ENST00000417059
Ensembl	ENST00000434618	http://www.ensembl.org/id/ENST00000434618
Ensembl	ENST00000456807	http://www.ensembl.org/id/ENST00000456807
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0042824	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042824
GO_component	GO:0071556	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071556
GO_function	GO:0015433	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015433
GO_function	GO:0042288	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042288
GO_function	GO:0042605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042605
GO_function	GO:0046978	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046978
GO_function	GO:0046979	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046979
GO_function	GO:0051082	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051082
GO_process	GO:0002474	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002474
GO_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GO_process	GO:0006890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006890
GO_process	GO:0006955	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006955
GO_process	GO:0010468	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010468
GO_process	GO:0019885	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019885
GO_process	GO:0050823	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050823
GO_process	GO:0061635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061635
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0051082	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051082
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
Gene3D	2.60.40.10	http://www.cathdb.info/version/latest/superfamily/2.60.40.10
GeneCards	TAPBP	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TAPBP
GeneID	6892	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6892
H-InvDB	HIX0058157	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0058157
H-InvDB	HIX0166135	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0166135
H-InvDB	HIX0166410	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0166410
HGNC	HGNC:11566	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11566
HOVERGEN	HBG005156	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG005156&db=HOVERGEN
HPA	HPA007066	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA007066
InParanoid	O15533	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O15533
IntAct	O15533	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O15533*
InterPro	IPR003597	http://www.ebi.ac.uk/interpro/entry/IPR003597
InterPro	IPR007110	http://www.ebi.ac.uk/interpro/entry/IPR007110
InterPro	IPR008056	http://www.ebi.ac.uk/interpro/entry/IPR008056
InterPro	IPR013783	http://www.ebi.ac.uk/interpro/entry/IPR013783
Jabion	6892	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6892
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Disease	H00984	http://www.genome.jp/dbget-bin/www_bget?H00984
KEGG_Gene	hsa:6892	http://www.genome.jp/dbget-bin/www_bget?hsa:6892
KEGG_Orthology	KO:K08058	http://www.genome.jp/dbget-bin/www_bget?KO:K08058
KEGG_Pathway	ko04612	http://www.genome.jp/kegg-bin/show_pathway?ko04612
MIM	601962	http://www.ncbi.nlm.nih.gov/omim/601962
MIM	604571	http://www.ncbi.nlm.nih.gov/omim/604571
MINT	MINT-4053688	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4053688
OMA	YLATVHL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YLATVHL
Orphanet	34592	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=34592
OrthoDB	EOG091G0ATU	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0ATU
PDB	3F8U	http://www.ebi.ac.uk/pdbe-srv/view/entry/3F8U
PDBsum	3F8U	http://www.ebi.ac.uk/pdbsum/3F8U
PRINTS	PR01669	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01669
PROSITE	PS50835	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50835
PSORT	swissprot:TPSN_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TPSN_HUMAN
PSORT-B	swissprot:TPSN_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TPSN_HUMAN
PSORT2	swissprot:TPSN_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TPSN_HUMAN
Pfam	PF07654	http://pfam.xfam.org/family/PF07654
PharmGKB	PA36331	http://www.pharmgkb.org/do/serve?objId=PA36331&objCls=Gene
Phobius	swissprot:TPSN_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TPSN_HUMAN
PhylomeDB	O15533	http://phylomedb.org/?seqid=O15533
ProteinModelPortal	O15533	http://www.proteinmodelportal.org/query/uniprot/O15533
PubMed	10088603	http://www.ncbi.nlm.nih.gov/pubmed/10088603
PubMed	10382748	http://www.ncbi.nlm.nih.gov/pubmed/10382748
PubMed	10636848	http://www.ncbi.nlm.nih.gov/pubmed/10636848
PubMed	12149238	http://www.ncbi.nlm.nih.gov/pubmed/12149238
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14668790	http://www.ncbi.nlm.nih.gov/pubmed/14668790
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19119025	http://www.ncbi.nlm.nih.gov/pubmed/19119025
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	20600451	http://www.ncbi.nlm.nih.gov/pubmed/20600451
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	9238042	http://www.ncbi.nlm.nih.gov/pubmed/9238042
PubMed	9271576	http://www.ncbi.nlm.nih.gov/pubmed/9271576
PubMed	9521053	http://www.ncbi.nlm.nih.gov/pubmed/9521053
PubMed	9545376	http://www.ncbi.nlm.nih.gov/pubmed/9545376
PubMed	9802609	http://www.ncbi.nlm.nih.gov/pubmed/9802609
Reactome	R-HSA-1236974	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1236974
Reactome	R-HSA-983170	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983170
RefSeq	NP_003181	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003181
RefSeq	NP_757345	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_757345
RefSeq	NP_757346	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_757346
SMR	O15533	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O15533
STRING	9606.ENSP00000404833	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000404833&targetmode=cogs
SUPFAM	SSF48726	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48726
UCSC	uc003odx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003odx&org=rat
UniGene	Hs.370937	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.370937
UniProtKB	TPSN_HUMAN	http://www.uniprot.org/uniprot/TPSN_HUMAN
UniProtKB-AC	O15533	http://www.uniprot.org/uniprot/O15533
charge	swissprot:TPSN_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TPSN_HUMAN
eggNOG	ENOG410II43	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410II43
eggNOG	ENOG4111QPK	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111QPK
epestfind	swissprot:TPSN_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TPSN_HUMAN
garnier	swissprot:TPSN_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TPSN_HUMAN
helixturnhelix	swissprot:TPSN_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TPSN_HUMAN
hmoment	swissprot:TPSN_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TPSN_HUMAN
iep	swissprot:TPSN_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TPSN_HUMAN
inforesidue	swissprot:TPSN_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TPSN_HUMAN
neXtProt	NX_O15533	http://www.nextprot.org/db/entry/NX_O15533
octanol	swissprot:TPSN_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TPSN_HUMAN
pepcoil	swissprot:TPSN_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TPSN_HUMAN
pepdigest	swissprot:TPSN_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TPSN_HUMAN
pepinfo	swissprot:TPSN_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TPSN_HUMAN
pepnet	swissprot:TPSN_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TPSN_HUMAN
pepstats	swissprot:TPSN_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TPSN_HUMAN
pepwheel	swissprot:TPSN_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TPSN_HUMAN
pepwindow	swissprot:TPSN_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TPSN_HUMAN
sigcleave	swissprot:TPSN_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TPSN_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TRPC6_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9Y210-1; Sequence=Displayed; Name=2; IsoId=Q9Y210-2; Sequence=VSP_006572; Name=3; IsoId=Q9Y210-3; Sequence=VSP_006573; 
# AltName	TRPC6_HUMAN	Transient receptor protein 6
# BioGrid	113076	12
# CCDS	CCDS8311	-. [Q9Y210-1]
# ChiTaRS	TRPC6	human
# DISEASE	TRPC6_HUMAN	Focal segmental glomerulosclerosis 2 (FSGS2) [MIM 603965]  A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. {ECO 0000269|PubMed 15879175, ECO 0000269|PubMed 15924139, ECO 0000269|PubMed 21734084}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000344327	ENSP00000340913; ENSG00000137672. [Q9Y210-1]
# Ensembl	ENST00000348423	ENSP00000343672; ENSG00000137672. [Q9Y210-2]
# Ensembl	ENST00000360497	ENSP00000353687; ENSG00000137672. [Q9Y210-3]
# ExpressionAtlas	Q9Y210	baseline and differential
# FUNCTION	TRPC6_HUMAN	Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. 
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:MGI.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0036057	slit diaphragm; IEA:Ensembl.
# GO_function	GO:0005262	calcium channel activity; TAS:Reactome.
# GO_function	GO:0015279	store-operated calcium channel activity; IBA:GO_Central.
# GO_function	GO:0070679	inositol 1,4,5 trisphosphate binding; IDA:BHF-UCL.
# GO_process	GO:0006812	cation transport; TAS:ProtInc.
# GO_process	GO:0006828	manganese ion transport; IBA:GO_Central.
# GO_process	GO:0007204	positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
# GO_process	GO:0007338	single fertilization; IBA:GO_Central.
# GO_process	GO:0007568	aging; IEA:Ensembl.
# GO_process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation; IEA:Ensembl.
# GO_process	GO:0030168	platelet activation; TAS:Reactome.
# GO_process	GO:0030182	neuron differentiation; IEA:Ensembl.
# GO_process	GO:0032414	positive regulation of ion transmembrane transporter activity; IDA:MGI.
# GO_process	GO:0045666	positive regulation of neuron differentiation; IEA:Ensembl.
# GO_process	GO:0050774	negative regulation of dendrite morphogenesis; IEA:Ensembl.
# GO_process	GO:0051480	regulation of cytosolic calcium ion concentration; IBA:GO_Central.
# GO_process	GO:0051928	positive regulation of calcium ion transport; IDA:MGI.
# GO_process	GO:0070301	cellular response to hydrogen peroxide; IEA:Ensembl.
# GO_process	GO:0070588	calcium ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0071456	cellular response to hypoxia; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007568	aging
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.25.40.20	-; 1.
# Genevisible	Q9Y210	HS
# HGNC	HGNC:12338	TRPC6
# INTERACTION	TRPC6_HUMAN	P20591 MX1; NbExp=4; IntAct=EBI-929362, EBI-929476; 
# IntAct	Q9Y210	2
# InterPro	IPR002110	Ankyrin_rpt
# InterPro	IPR002153	TRPC_channel
# InterPro	IPR004729	TRP_channel
# InterPro	IPR005462	TRPC6_channel
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR013555	TRP_dom
# InterPro	IPR020683	Ankyrin_rpt-contain_dom
# KEGG_Brite	ko04040	Ion channels
# KEGG_Disease	H00626	[Kidney disease] Focal segmental glomerulosclerosis
# MIM	603652	gene
# MIM	603965	phenotype
# Organism	TRPC6_HUMAN	Homo sapiens (Human)
# Orphanet	93213	Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis
# PANTHER	PTHR10117	PTHR10117; 2
# PANTHER	PTHR10117:SF7	PTHR10117:SF7; 2
# PRINTS	PR01097	TRNSRECEPTRP
# PRINTS	PR01647	TRPCHANNEL6
# PROSITE	PS50088	ANK_REPEAT
# PROSITE	PS50297	ANK_REP_REGION; 2
# PTM	TRPC6_HUMAN	Phosphorylated by FYN, leading to an increase of TRPC6 channel activity. {ECO 0000250}. 
# Pfam	PF00520	Ion_trans
# Pfam	PF08344	TRP_2
# Pfam	PF12796	Ank_2
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-114508	Effects of PIP2 hydrolysis
# Reactome	R-HSA-139853	Elevation of cytosolic Ca2+ levels
# Reactome	R-HSA-3295583	TRP channels
# Reactome	R-HSA-418890	Role of second messengers in netrin-1 signaling
# RecName	TRPC6_HUMAN	Short transient receptor potential channel 6
# RefSeq	NP_004612	NM_004621.5. [Q9Y210-1]
# RefSeq	XP_016873710	XM_017018221.1. [Q9Y210-2]
# SIMILARITY	Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 4 ANK repeats. {ECO:0000255|PROSITE- ProRule	PRU00023}.
# SMART	SM00248	ANK; 3
# SUBCELLULAR LOCATION	TRPC6_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUBUNIT	TRPC6_HUMAN	Interacts with MX1 and RNF24. {ECO 0000269|PubMed 15757897, ECO 0000269|PubMed 17850865}. 
# SUPFAM	SSF48403	SSF48403
# TCDB	1.A.4.1	the transient receptor potential ca(2+) channel (trp-cc) family
# TIGRFAMs	TIGR00870	trp
# TISSUE SPECIFICITY	Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm. {ECO:0000269|PubMed	15924139}. 
# UCSC	uc001pgk	human. [Q9Y210-1]
# eggNOG	ENOG410XQ0Y	LUCA
# eggNOG	KOG3609	Eukaryota
BLAST	swissprot:TRPC6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TRPC6_HUMAN
BioCyc	ZFISH:ENSG00000137672-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000137672-MONOMER
COXPRESdb	7225	http://coxpresdb.jp/data/gene/7225.shtml
CleanEx	HS_TRPC6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TRPC6
DOI	10.1016/j.ceca.2007.07.009	http://dx.doi.org/10.1016/j.ceca.2007.07.009
DOI	10.1021/pr0704130	http://dx.doi.org/10.1021/pr0704130
DOI	10.1038/16711	http://dx.doi.org/10.1038/16711
DOI	10.1038/ng1592	http://dx.doi.org/10.1038/ng1592
DOI	10.1074/jbc.M003408200	http://dx.doi.org/10.1074/jbc.M003408200
DOI	10.1074/jbc.M302983200	http://dx.doi.org/10.1074/jbc.M302983200
DOI	10.1074/jbc.M500391200	http://dx.doi.org/10.1074/jbc.M500391200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1106215	http://dx.doi.org/10.1126/science.1106215
DOI	10.2215/CJN.07830910	http://dx.doi.org/10.2215/CJN.07830910
EMBL	AF080394	http://www.ebi.ac.uk/ena/data/view/AF080394
EMBL	AJ006276	http://www.ebi.ac.uk/ena/data/view/AJ006276
EMBL	AJ007018	http://www.ebi.ac.uk/ena/data/view/AJ007018
EMBL	AJ271066	http://www.ebi.ac.uk/ena/data/view/AJ271066
EMBL	AJ271067	http://www.ebi.ac.uk/ena/data/view/AJ271067
EMBL	AJ271068	http://www.ebi.ac.uk/ena/data/view/AJ271068
EMBL	BC093658	http://www.ebi.ac.uk/ena/data/view/BC093658
EMBL	BC093660	http://www.ebi.ac.uk/ena/data/view/BC093660
Ensembl	ENST00000344327	http://www.ensembl.org/id/ENST00000344327
Ensembl	ENST00000348423	http://www.ensembl.org/id/ENST00000348423
Ensembl	ENST00000360497	http://www.ensembl.org/id/ENST00000360497
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0036057	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036057
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0015279	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015279
GO_function	GO:0070679	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070679
GO_process	GO:0006812	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006812
GO_process	GO:0006828	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006828
GO_process	GO:0007204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007204
GO_process	GO:0007338	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007338
GO_process	GO:0007568	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007568
GO_process	GO:0010800	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010800
GO_process	GO:0030168	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030168
GO_process	GO:0030182	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030182
GO_process	GO:0032414	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032414
GO_process	GO:0045666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045666
GO_process	GO:0050774	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050774
GO_process	GO:0051480	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051480
GO_process	GO:0051928	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051928
GO_process	GO:0070301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070301
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:0071456	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071456
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007568	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007568
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.25.40.20	http://www.cathdb.info/version/latest/superfamily/1.25.40.20
GeneCards	TRPC6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TRPC6
GeneID	7225	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7225
GeneTree	ENSGT00760000119180	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119180
HGNC	HGNC:12338	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:12338
HOGENOM	HOG000020590	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000020590&db=HOGENOM6
HOVERGEN	HBG068337	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG068337&db=HOVERGEN
HPA	HPA045098	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA045098
InParanoid	Q9Y210	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y210
IntAct	Q9Y210	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9Y210*
InterPro	IPR002110	http://www.ebi.ac.uk/interpro/entry/IPR002110
InterPro	IPR002153	http://www.ebi.ac.uk/interpro/entry/IPR002153
InterPro	IPR004729	http://www.ebi.ac.uk/interpro/entry/IPR004729
InterPro	IPR005462	http://www.ebi.ac.uk/interpro/entry/IPR005462
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR013555	http://www.ebi.ac.uk/interpro/entry/IPR013555
InterPro	IPR020683	http://www.ebi.ac.uk/interpro/entry/IPR020683
Jabion	7225	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7225
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00626	http://www.genome.jp/dbget-bin/www_bget?H00626
KEGG_Gene	hsa:7225	http://www.genome.jp/dbget-bin/www_bget?hsa:7225
KEGG_Orthology	KO:K04969	http://www.genome.jp/dbget-bin/www_bget?KO:K04969
MIM	603652	http://www.ncbi.nlm.nih.gov/omim/603652
MIM	603965	http://www.ncbi.nlm.nih.gov/omim/603965
OMA	QAPLPCY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QAPLPCY
Orphanet	93213	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=93213
OrthoDB	EOG091G01FB	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01FB
PANTHER	PTHR10117	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10117
PANTHER	PTHR10117:SF7	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10117:SF7
PRINTS	PR01097	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01097
PRINTS	PR01647	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01647
PROSITE	PS50088	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50088
PROSITE	PS50297	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50297
PSORT	swissprot:TRPC6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TRPC6_HUMAN
PSORT-B	swissprot:TRPC6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TRPC6_HUMAN
PSORT2	swissprot:TRPC6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TRPC6_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF08344	http://pfam.xfam.org/family/PF08344
Pfam	PF12796	http://pfam.xfam.org/family/PF12796
PharmGKB	PA37011	http://www.pharmgkb.org/do/serve?objId=PA37011&objCls=Gene
Phobius	swissprot:TRPC6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TRPC6_HUMAN
PhylomeDB	Q9Y210	http://phylomedb.org/?seqid=Q9Y210
ProteinModelPortal	Q9Y210	http://www.proteinmodelportal.org/query/uniprot/Q9Y210
PubMed	10816590	http://www.ncbi.nlm.nih.gov/pubmed/10816590
PubMed	12970363	http://www.ncbi.nlm.nih.gov/pubmed/12970363
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15757897	http://www.ncbi.nlm.nih.gov/pubmed/15757897
PubMed	15879175	http://www.ncbi.nlm.nih.gov/pubmed/15879175
PubMed	15924139	http://www.ncbi.nlm.nih.gov/pubmed/15924139
PubMed	17850865	http://www.ncbi.nlm.nih.gov/pubmed/17850865
PubMed	18088087	http://www.ncbi.nlm.nih.gov/pubmed/18088087
PubMed	21734084	http://www.ncbi.nlm.nih.gov/pubmed/21734084
PubMed	9925922	http://www.ncbi.nlm.nih.gov/pubmed/9925922
PubMed	9930701	http://www.ncbi.nlm.nih.gov/pubmed/9930701
Reactome	R-HSA-114508	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-114508
Reactome	R-HSA-139853	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-139853
Reactome	R-HSA-3295583	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3295583
Reactome	R-HSA-418890	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418890
RefSeq	NP_004612	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004612
RefSeq	XP_016873710	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016873710
SMART	SM00248	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00248
STRING	9606.ENSP00000340913	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000340913&targetmode=cogs
SUPFAM	SSF48403	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48403
TCDB	1.A.4.1	http://www.tcdb.org/search/result.php?tc=1.A.4.1
TIGRFAMs	TIGR00870	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00870
UCSC	uc001pgk	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001pgk&org=rat
UniGene	Hs.159003	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.159003
UniProtKB	TRPC6_HUMAN	http://www.uniprot.org/uniprot/TRPC6_HUMAN
UniProtKB-AC	Q9Y210	http://www.uniprot.org/uniprot/Q9Y210
charge	swissprot:TRPC6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TRPC6_HUMAN
eggNOG	ENOG410XQ0Y	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ0Y
eggNOG	KOG3609	http://eggnogapi.embl.de/nog_data/html/tree/KOG3609
epestfind	swissprot:TRPC6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TRPC6_HUMAN
garnier	swissprot:TRPC6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TRPC6_HUMAN
helixturnhelix	swissprot:TRPC6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRPC6_HUMAN
hmoment	swissprot:TRPC6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TRPC6_HUMAN
iep	swissprot:TRPC6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TRPC6_HUMAN
inforesidue	swissprot:TRPC6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TRPC6_HUMAN
neXtProt	NX_Q9Y210	http://www.nextprot.org/db/entry/NX_Q9Y210
octanol	swissprot:TRPC6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TRPC6_HUMAN
pepcoil	swissprot:TRPC6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TRPC6_HUMAN
pepdigest	swissprot:TRPC6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TRPC6_HUMAN
pepinfo	swissprot:TRPC6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TRPC6_HUMAN
pepnet	swissprot:TRPC6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TRPC6_HUMAN
pepstats	swissprot:TRPC6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TRPC6_HUMAN
pepwheel	swissprot:TRPC6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TRPC6_HUMAN
pepwindow	swissprot:TRPC6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TRPC6_HUMAN
sigcleave	swissprot:TRPC6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TRPC6_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CTL2_HUMAN	Event=Alternative promoter usage, Alternative splicing; Named isoforms=3; Name=1; Synonyms=CTL2a, CTL2P2A; IsoId=Q8IWA5-1; Sequence=Displayed; Name=2; Synonyms=CTL2b, CTL2P2B; IsoId=Q8IWA5-2; Sequence=VSP_015431; Name=3; Synonyms=CTL2P1; IsoId=Q8IWA5-3; Sequence=VSP_041792; Note=Produced by alternative promoter usage.; 
# AltName	CTL2_HUMAN	Solute carrier family 44 member 2
# CCDS	CCDS12245	-. [Q8IWA5-1]
# CCDS	CCDS54216	-. [Q8IWA5-3]
# ChiTaRS	SLC44A2	human
# DrugBank	DB00122	Choline
# Ensembl	ENST00000335757	ENSP00000336888; ENSG00000129353. [Q8IWA5-1]
# Ensembl	ENST00000407327	ENSP00000385135; ENSG00000129353. [Q8IWA5-3]
# Ensembl	ENST00000586078	ENSP00000466664; ENSG00000129353. [Q8IWA5-2]
# ExpressionAtlas	Q8IWA5	baseline and differential
# FUNCTION	CTL2_HUMAN	Isoform 1, but not isoform 3, exhibits some choline transporter activity. {ECO 0000269|PubMed 10677542, ECO 0000269|PubMed 20665236}. 
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; TAS:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0004871	signal transducer activity; IMP:UniProtKB.
# GO_function	GO:0015220	choline transmembrane transporter activity; TAS:UniProtKB.
# GO_process	GO:0006656	phosphatidylcholine biosynthetic process; TAS:Reactome.
# GO_process	GO:0015871	choline transport; TAS:UniProtKB.
# GO_process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q8IWA5	HS
# HGNC	HGNC:17292	SLC44A2
# InterPro	IPR007603	Choline_transptr-like
# KEGG_Brite	ko02001	Solute carrier family
# MIM	606106	gene
# Organism	CTL2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12385	PTHR12385; 2
# Pfam	PF04515	Choline_transpo
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-1483191	Synthesis of PC
# Reactome	R-HSA-425366	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
# Reactome	R-HSA-6798695	Neutrophil degranulation
# RecName	CTL2_HUMAN	Choline transporter-like protein 2
# RefSeq	NP_001138528	NM_001145056.1. [Q8IWA5-3]
# RefSeq	NP_065161	NM_020428.3. [Q8IWA5-1]
# RefSeq	XP_005260054	XM_005259997.1. [Q8IWA5-2]
# SEQUENCE CAUTION	Sequence=BAC11662.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the CTL (choline transporter-like) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	CTL2_HUMAN	Membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUBUNIT	Interacts with COCH. {ECO:0000269|PubMed	17926100}. 
# TCDB	2.A.92.1	the choline transporter-like (ctl) family
# TISSUE SPECIFICITY	CTL2_HUMAN	Present in supporting cells of the inner ear (at protein level). Only isoform 3 is expressed in inner ear vestibular tissue. {ECO 0000269|PubMed 14973250, ECO 0000269|PubMed 20665236}. 
# UCSC	uc002mpe	human. [Q8IWA5-1]
# eggNOG	ENOG410XS0P	LUCA
# eggNOG	KOG1362	Eukaryota
BLAST	swissprot:CTL2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CTL2_HUMAN
COXPRESdb	57153	http://coxpresdb.jp/data/gene/57153.shtml
CleanEx	HS_SLC44A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC44A2
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1007/s10162-007-0099-2	http://dx.doi.org/10.1007/s10162-007-0099-2
DOI	10.1007/s10930-010-9268-y	http://dx.doi.org/10.1007/s10930-010-9268-y
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DOI	10.1038/nbt.1532	http://dx.doi.org/10.1038/nbt.1532
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.030339697	http://dx.doi.org/10.1073/pnas.030339697
DOI	10.1093/dnares/12.2.117	http://dx.doi.org/10.1093/dnares/12.2.117
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.1523/JNEUROSCI.5063-03.2004	http://dx.doi.org/10.1523/JNEUROSCI.5063-03.2004
DrugBank	DB00122	http://www.drugbank.ca/drugs/DB00122
EMBL	AC011475	http://www.ebi.ac.uk/ena/data/view/AC011475
EMBL	AF070636	http://www.ebi.ac.uk/ena/data/view/AF070636
EMBL	AJ245621	http://www.ebi.ac.uk/ena/data/view/AJ245621
EMBL	AK027519	http://www.ebi.ac.uk/ena/data/view/AK027519
EMBL	AK075512	http://www.ebi.ac.uk/ena/data/view/AK075512
EMBL	AK294118	http://www.ebi.ac.uk/ena/data/view/AK294118
EMBL	AK314582	http://www.ebi.ac.uk/ena/data/view/AK314582
EMBL	AL832517	http://www.ebi.ac.uk/ena/data/view/AL832517
EMBL	AL832978	http://www.ebi.ac.uk/ena/data/view/AL832978
EMBL	BC010617	http://www.ebi.ac.uk/ena/data/view/BC010617
EMBL	BC040556	http://www.ebi.ac.uk/ena/data/view/BC040556
EMBL	CH471106	http://www.ebi.ac.uk/ena/data/view/CH471106
EMBL	FN668568	http://www.ebi.ac.uk/ena/data/view/FN668568
Ensembl	ENST00000335757	http://www.ensembl.org/id/ENST00000335757
Ensembl	ENST00000407327	http://www.ensembl.org/id/ENST00000407327
Ensembl	ENST00000586078	http://www.ensembl.org/id/ENST00000586078
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GO_function	GO:0015220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015220
GO_process	GO:0006656	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006656
GO_process	GO:0015871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015871
GO_process	GO:0043123	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043123
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC44A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC44A2
GeneID	57153	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57153
GeneTree	ENSGT00550000074521	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074521
H-InvDB	HIX0202740	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0202740
HGNC	HGNC:17292	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17292
HOVERGEN	HBG062155	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG062155&db=HOVERGEN
HPA	HPA003228	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA003228
InParanoid	Q8IWA5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8IWA5
IntAct	Q8IWA5	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8IWA5*
InterPro	IPR007603	http://www.ebi.ac.uk/interpro/entry/IPR007603
Jabion	57153	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=57153
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:57153	http://www.genome.jp/dbget-bin/www_bget?hsa:57153
KEGG_Orthology	KO:K15377	http://www.genome.jp/dbget-bin/www_bget?KO:K15377
MIM	606106	http://www.ncbi.nlm.nih.gov/omim/606106
MINT	MINT-5006445	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5006445
OMA	QHYYGKH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QHYYGKH
OrthoDB	EOG091G04CQ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G04CQ
PANTHER	PTHR12385	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12385
PSORT	swissprot:CTL2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CTL2_HUMAN
PSORT-B	swissprot:CTL2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CTL2_HUMAN
PSORT2	swissprot:CTL2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CTL2_HUMAN
Pfam	PF04515	http://pfam.xfam.org/family/PF04515
PharmGKB	PA142670899	http://www.pharmgkb.org/do/serve?objId=PA142670899&objCls=Gene
Phobius	swissprot:CTL2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CTL2_HUMAN
PhylomeDB	Q8IWA5	http://phylomedb.org/?seqid=Q8IWA5
ProteinModelPortal	Q8IWA5	http://www.proteinmodelportal.org/query/uniprot/Q8IWA5
PubMed	10677542	http://www.ncbi.nlm.nih.gov/pubmed/10677542
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	14973250	http://www.ncbi.nlm.nih.gov/pubmed/14973250
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16303743	http://www.ncbi.nlm.nih.gov/pubmed/16303743
PubMed	17926100	http://www.ncbi.nlm.nih.gov/pubmed/17926100
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	19349973	http://www.ncbi.nlm.nih.gov/pubmed/19349973
PubMed	20665236	http://www.ncbi.nlm.nih.gov/pubmed/20665236
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-1483191	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1483191
Reactome	R-HSA-425366	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425366
Reactome	R-HSA-6798695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6798695
RefSeq	NP_001138528	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001138528
RefSeq	NP_065161	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_065161
RefSeq	XP_005260054	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005260054
SMR	Q8IWA5	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8IWA5
STRING	9606.ENSP00000336888	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000336888&targetmode=cogs
TCDB	2.A.92.1	http://www.tcdb.org/search/result.php?tc=2.A.92.1
UCSC	uc002mpe	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002mpe&org=rat
UniGene	Hs.534560	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.534560
UniProtKB	CTL2_HUMAN	http://www.uniprot.org/uniprot/CTL2_HUMAN
UniProtKB-AC	Q8IWA5	http://www.uniprot.org/uniprot/Q8IWA5
charge	swissprot:CTL2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CTL2_HUMAN
eggNOG	ENOG410XS0P	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS0P
eggNOG	KOG1362	http://eggnogapi.embl.de/nog_data/html/tree/KOG1362
epestfind	swissprot:CTL2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CTL2_HUMAN
garnier	swissprot:CTL2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CTL2_HUMAN
helixturnhelix	swissprot:CTL2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CTL2_HUMAN
hmoment	swissprot:CTL2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CTL2_HUMAN
iep	swissprot:CTL2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CTL2_HUMAN
inforesidue	swissprot:CTL2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CTL2_HUMAN
neXtProt	NX_Q8IWA5	http://www.nextprot.org/db/entry/NX_Q8IWA5
octanol	swissprot:CTL2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CTL2_HUMAN
pepcoil	swissprot:CTL2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CTL2_HUMAN
pepdigest	swissprot:CTL2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CTL2_HUMAN
pepinfo	swissprot:CTL2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CTL2_HUMAN
pepnet	swissprot:CTL2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CTL2_HUMAN
pepstats	swissprot:CTL2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CTL2_HUMAN
pepwheel	swissprot:CTL2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CTL2_HUMAN
pepwindow	swissprot:CTL2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CTL2_HUMAN
sigcleave	swissprot:CTL2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CTL2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	P2RX5_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q93086-3; Sequence=Displayed; Name=2; Synonyms=A; IsoId=Q93086-1; Sequence=VSP_035587; Name=3; Synonyms=B; IsoId=Q93086-2; Sequence=VSP_004503, VSP_035587; Name=4; IsoId=Q93086-4; Sequence=VSP_035588; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=5; IsoId=Q93086-5; Sequence=VSP_004503; 
# AltName	P2RX5_HUMAN	ATP receptor
# AltName	P2RX5_HUMAN	Purinergic receptor
# BioGrid	111065	23
# CCDS	CCDS11034	-. [Q93086-3]
# CCDS	CCDS11035	-. [Q93086-2]
# CCDS	CCDS56014	-. [Q93086-5]
# CCDS	CCDS56015	-. [Q93086-1]
# ChiTaRS	P2RX5	human
# Ensembl	ENST00000225328	ENSP00000225328; ENSG00000083454. [Q93086-3]
# Ensembl	ENST00000345901	ENSP00000342161; ENSG00000083454. [Q93086-5]
# Ensembl	ENST00000547178	ENSP00000448355; ENSG00000083454. [Q93086-1]
# Ensembl	ENST00000551178	ENSP00000447545; ENSG00000083454. [Q93086-2]
# ExpressionAtlas	Q93086	baseline and differential
# FUNCTION	P2RX5_HUMAN	Receptor for ATP that acts as a ligand-gated ion channel. 
# GO_component	GO:0005639	integral component of nuclear inner membrane; IBA:GO_Central.
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_function	GO:0001614	purinergic nucleotide receptor activity; NAS:BHF-UCL.
# GO_function	GO:0004888	transmembrane signaling receptor activity; TAS:ProtInc.
# GO_function	GO:0004931	extracellular ATP-gated cation channel activity; NAS:BHF-UCL.
# GO_function	GO:0005216	ion channel activity; TAS:ProtInc.
# GO_function	GO:0005524	ATP binding; NAS:BHF-UCL.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0007399	nervous system development; TAS:ProtInc.
# GO_process	GO:0007596	blood coagulation; TAS:Reactome.
# GO_process	GO:0010524	positive regulation of calcium ion transport into cytosol; NAS:BHF-UCL.
# GO_process	GO:0033198	response to ATP; IEA:InterPro.
# GO_process	GO:0050850	positive regulation of calcium-mediated signaling; NAS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# Gene3D	2.60.490.10	-; 1.
# Genevisible	Q93086	HS
# HGNC	HGNC:8536	P2RX5
# IntAct	Q93086	2
# InterPro	IPR001429	P2X_purnocptor
# InterPro	IPR003048	P2X5_purnocptor
# InterPro	IPR027309	P2X_extracellular_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# MIM	602836	gene
# Organism	P2RX5_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10125	PTHR10125
# PANTHER	PTHR10125:SF12	PTHR10125:SF12
# PRINTS	PR01307	P2XRECEPTOR
# PRINTS	PR01312	P2X5RECEPTOR
# PROSITE	PS01212	P2X_RECEPTOR
# Pfam	PF00864	P2X_receptor
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-139853	Elevation of cytosolic Ca2+ levels
# Reactome	R-HSA-418346	Platelet homeostasis
# RecName	P2RX5_HUMAN	P2X purinoceptor 5
# RefSeq	NP_001191448	NM_001204519.1. [Q93086-1]
# RefSeq	NP_001191449	NM_001204520.1. [Q93086-5]
# RefSeq	NP_002552	NM_002561.3. [Q93086-3]
# RefSeq	NP_778255	NM_175080.2. [Q93086-2]
# SEQUENCE CAUTION	P2RX5_HUMAN	Sequence=AAF43106.1; Type=Erroneous gene model prediction; Evidence={ECO 0000305}; Sequence=AK307959; Type=Frameshift; Positions=112; Evidence={ECO 0000305}; Sequence=BAD92860.1; Type=Frameshift; Positions=112; Evidence={ECO 0000305}; Sequence=BC028084; Type=Frameshift; Positions=112; Evidence={ECO 0000305}; 
# SIMILARITY	Belongs to the P2X receptor family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	P2RX5_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Functional P2XRs are organized as homomeric and heteromeric trimers. {ECO	0000250}. 
# TIGRFAMs	TIGR00863	P2X
# TISSUE SPECIFICITY	P2RX5_HUMAN	Expressed at high levels in brain and immune system. 
# UCSC	uc002fwi	human. [Q93086-3]
# WEB RESOURCE	P2RX5_HUMAN	Name=Wikipedia; Note=P2X receptor entry; URL="https //en.wikipedia.org/wiki/P2X_receptor";
# eggNOG	ENOG410IFJF	Eukaryota
# eggNOG	ENOG410XR0C	LUCA
BLAST	swissprot:P2RX5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:P2RX5_HUMAN
BioCyc	ZFISH:ENSG00000083454-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000083454-MONOMER
COXPRESdb	5026	http://coxpresdb.jp/data/gene/5026.shtml
CleanEx	HS_P2RX5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_P2RX5
DOI	10.1016/S0014-5793(97)01380-X	http://dx.doi.org/10.1016/S0014-5793(97)01380-X
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.10.2.165	http://dx.doi.org/10.1101/gr.10.2.165
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB209623	http://www.ebi.ac.uk/ena/data/view/AB209623
EMBL	AC132942	http://www.ebi.ac.uk/ena/data/view/AC132942
EMBL	AF016709	http://www.ebi.ac.uk/ena/data/view/AF016709
EMBL	AF070573	http://www.ebi.ac.uk/ena/data/view/AF070573
EMBL	AF168787	http://www.ebi.ac.uk/ena/data/view/AF168787
EMBL	AF168787	http://www.ebi.ac.uk/ena/data/view/AF168787
EMBL	AK290889	http://www.ebi.ac.uk/ena/data/view/AK290889
EMBL	AK307959	http://www.ebi.ac.uk/ena/data/view/AK307959
EMBL	BC028084	http://www.ebi.ac.uk/ena/data/view/BC028084
EMBL	BC039015	http://www.ebi.ac.uk/ena/data/view/BC039015
EMBL	CH471108	http://www.ebi.ac.uk/ena/data/view/CH471108
EMBL	DQ234349	http://www.ebi.ac.uk/ena/data/view/DQ234349
EMBL	U49395	http://www.ebi.ac.uk/ena/data/view/U49395
EMBL	U49396	http://www.ebi.ac.uk/ena/data/view/U49396
Ensembl	ENST00000225328	http://www.ensembl.org/id/ENST00000225328
Ensembl	ENST00000345901	http://www.ensembl.org/id/ENST00000345901
Ensembl	ENST00000547178	http://www.ensembl.org/id/ENST00000547178
Ensembl	ENST00000551178	http://www.ensembl.org/id/ENST00000551178
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005639	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005639
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0001614	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001614
GO_function	GO:0004888	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004888
GO_function	GO:0004931	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004931
GO_function	GO:0005216	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005216
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007399	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007399
GO_process	GO:0007596	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007596
GO_process	GO:0010524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010524
GO_process	GO:0033198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033198
GO_process	GO:0050850	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050850
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
Gene3D	2.60.490.10	http://www.cathdb.info/version/latest/superfamily/2.60.490.10
GeneCards	P2RX5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=P2RX5
GeneID	5026	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5026
GeneTree	ENSGT00390000016028	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000016028
HGNC	HGNC:8536	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:8536
HOGENOM	HOG000232042	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000232042&db=HOGENOM6
HOVERGEN	HBG053086	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053086&db=HOVERGEN
HPA	HPA021948	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA021948
HPA	HPA067827	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA067827
InParanoid	Q93086	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q93086
IntAct	Q93086	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q93086*
InterPro	IPR001429	http://www.ebi.ac.uk/interpro/entry/IPR001429
InterPro	IPR003048	http://www.ebi.ac.uk/interpro/entry/IPR003048
InterPro	IPR027309	http://www.ebi.ac.uk/interpro/entry/IPR027309
Jabion	5026	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=5026
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:5026	http://www.genome.jp/dbget-bin/www_bget?hsa:5026
KEGG_Orthology	KO:K05219	http://www.genome.jp/dbget-bin/www_bget?KO:K05219
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
MIM	602836	http://www.ncbi.nlm.nih.gov/omim/602836
OMA	AGAFFCD	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AGAFFCD
PANTHER	PTHR10125	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10125
PANTHER	PTHR10125:SF12	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10125:SF12
PRINTS	PR01307	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01307
PRINTS	PR01312	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01312
PROSITE	PS01212	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01212
PSORT	swissprot:P2RX5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:P2RX5_HUMAN
PSORT-B	swissprot:P2RX5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:P2RX5_HUMAN
PSORT2	swissprot:P2RX5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:P2RX5_HUMAN
Pfam	PF00864	http://pfam.xfam.org/family/PF00864
PharmGKB	PA32865	http://www.pharmgkb.org/do/serve?objId=PA32865&objCls=Gene
Phobius	swissprot:P2RX5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:P2RX5_HUMAN
PhylomeDB	Q93086	http://phylomedb.org/?seqid=Q93086
ProteinModelPortal	Q93086	http://www.proteinmodelportal.org/query/uniprot/Q93086
PubMed	10673275	http://www.ncbi.nlm.nih.gov/pubmed/10673275
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	9414125	http://www.ncbi.nlm.nih.gov/pubmed/9414125
Reactome	R-HSA-139853	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-139853
Reactome	R-HSA-418346	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418346
RefSeq	NP_001191448	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001191448
RefSeq	NP_001191449	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001191449
RefSeq	NP_002552	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002552
RefSeq	NP_778255	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_778255
SMR	Q93086	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q93086
STRING	9606.ENSP00000225328	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000225328&targetmode=cogs
TIGRFAMs	TIGR00863	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00863
UCSC	uc002fwi	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002fwi&org=rat
UniGene	Hs.731607	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.731607
UniProtKB	P2RX5_HUMAN	http://www.uniprot.org/uniprot/P2RX5_HUMAN
UniProtKB-AC	Q93086	http://www.uniprot.org/uniprot/Q93086
charge	swissprot:P2RX5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:P2RX5_HUMAN
eggNOG	ENOG410IFJF	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IFJF
eggNOG	ENOG410XR0C	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XR0C
epestfind	swissprot:P2RX5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:P2RX5_HUMAN
garnier	swissprot:P2RX5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:P2RX5_HUMAN
helixturnhelix	swissprot:P2RX5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:P2RX5_HUMAN
hmoment	swissprot:P2RX5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:P2RX5_HUMAN
iep	swissprot:P2RX5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:P2RX5_HUMAN
inforesidue	swissprot:P2RX5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:P2RX5_HUMAN
neXtProt	NX_Q93086	http://www.nextprot.org/db/entry/NX_Q93086
octanol	swissprot:P2RX5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:P2RX5_HUMAN
pepcoil	swissprot:P2RX5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:P2RX5_HUMAN
pepdigest	swissprot:P2RX5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:P2RX5_HUMAN
pepinfo	swissprot:P2RX5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:P2RX5_HUMAN
pepnet	swissprot:P2RX5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:P2RX5_HUMAN
pepstats	swissprot:P2RX5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:P2RX5_HUMAN
pepwheel	swissprot:P2RX5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:P2RX5_HUMAN
pepwindow	swissprot:P2RX5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:P2RX5_HUMAN
sigcleave	swissprot:P2RX5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:P2RX5_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	5HT3E_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=A5X5Y0-1; Sequence=Displayed; Name=2; Synonyms=5-HT3c1; IsoId=A5X5Y0-2; Sequence=VSP_029804; Name=3; IsoId=A5X5Y0-3; Sequence=VSP_029803; Name=4; Synonyms=5-HT3c1 long; IsoId=A5X5Y0-4; Sequence=VSP_029803, VSP_029804; Name=5; Synonyms=HTR3E_V3; IsoId=A5X5Y0-6; Sequence=VSP_029803, VSP_029804, VSP_045573; 
# AltName	5HT3E_HUMAN	Serotonin receptor 3E
# BioGrid	130056	6
# CCDS	CCDS3251	-. [A5X5Y0-3]
# CCDS	CCDS58868	-. [A5X5Y0-1]
# CCDS	CCDS58869	-. [A5X5Y0-2]
# CCDS	CCDS58870	-. [A5X5Y0-4]
# CCDS	CCDS58871	-. [A5X5Y0-6]
# DrugBank	DB00898	Ethanol
# DrugBank	DB01049	Ergoloid mesylate
# Ensembl	ENST00000335304	ENSP00000335511; ENSG00000186038. [A5X5Y0-3]
# Ensembl	ENST00000415389	ENSP00000401444; ENSG00000186038. [A5X5Y0-1]
# Ensembl	ENST00000425359	ENSP00000401900; ENSG00000186038. [A5X5Y0-2]
# Ensembl	ENST00000436361	ENSP00000395833; ENSG00000186038. [A5X5Y0-4]
# Ensembl	ENST00000440596	ENSP00000406050; ENSG00000186038. [A5X5Y0-6]
# ExpressionAtlas	A5X5Y0	baseline and differential
# FUNCTION	5HT3E_HUMAN	This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0004993	G-protein coupled serotonin receptor activity; IDA:CACAO.
# GO_function	GO:0005232	serotonin-activated cation-selective channel activity; IBA:GO_Central.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.370	-; 2.
# Gene3D	2.70.170.10	-; 1.
# HGNC	HGNC:24005	HTR3E
# INTERACTION	5HT3E_HUMAN	P46098 HTR3A; NbExp=5; IntAct=EBI-11174612, EBI-9008743; 
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# InterPro	IPR027361	Acetylcholine_rcpt_TM
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04726	Serotonergic synapse
# MIM	610123	gene
# Organism	5HT3E_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR18945	PTHR18945
# PRINTS	PR00252	NRIONCHANNEL
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-975298	Ligand-gated ion channel transport
# RecName	5HT3E_HUMAN	5-hydroxytryptamine receptor 3E
# RefSeq	NP_001243542	NM_001256613.1. [A5X5Y0-1]
# RefSeq	NP_001243543	NM_001256614.1. [A5X5Y0-6]
# RefSeq	NP_872395	NM_182589.2. [A5X5Y0-3]
# RefSeq	NP_938055	NM_198313.2. [A5X5Y0-2]
# RefSeq	NP_938056	NM_198314.2. [A5X5Y0-4]
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3E sub-subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	5HT3E_HUMAN	Cell membrane {ECO 0000269|PubMed 17392525, ECO 0000269|PubMed 19012743}; Multi-pass membrane protein {ECO 0000269|PubMed 17392525, ECO 0000269|PubMed 19012743}. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. 
# SUBUNIT	Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex. {ECO:0000269|PubMed	17392525}. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TISSUE SPECIFICITY	5HT3E_HUMAN	Expressed in adult colon and intestine. {ECO 0000269|PubMed 12801637, ECO 0000269|PubMed 14597179}. 
# UCSC	uc003fml	human. [A5X5Y0-1]
# eggNOG	ENOG410XQGR	LUCA
# eggNOG	KOG3645	Eukaryota
BLAST	swissprot:5HT3E_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:5HT3E_HUMAN
BioCyc	ZFISH:G66-33727-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33727-MONOMER
COXPRESdb	285242	http://coxpresdb.jp/data/gene/285242.shtml
CleanEx	HS_HTR3E	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_HTR3E
DOI	10.1016/S0378-1119(03)00503-1	http://dx.doi.org/10.1016/S0378-1119(03)00503-1
DOI	10.1016/S0378-1119(03)00803-5	http://dx.doi.org/10.1016/S0378-1119(03)00803-5
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1471-4159.2008.05775.x	http://dx.doi.org/10.1111/j.1471-4159.2008.05775.x
DOI	10.1124/mol.106.032144	http://dx.doi.org/10.1124/mol.106.032144
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01049	http://www.drugbank.ca/drugs/DB01049
EMBL	AC131235	http://www.ebi.ac.uk/ena/data/view/AC131235
EMBL	AY159813	http://www.ebi.ac.uk/ena/data/view/AY159813
EMBL	AY349352	http://www.ebi.ac.uk/ena/data/view/AY349352
EMBL	AY349353	http://www.ebi.ac.uk/ena/data/view/AY349353
EMBL	BC101182	http://www.ebi.ac.uk/ena/data/view/BC101182
EMBL	BC101183	http://www.ebi.ac.uk/ena/data/view/BC101183
EMBL	BC101185	http://www.ebi.ac.uk/ena/data/view/BC101185
EMBL	DQ644022	http://www.ebi.ac.uk/ena/data/view/DQ644022
EMBL	EU165354	http://www.ebi.ac.uk/ena/data/view/EU165354
Ensembl	ENST00000335304	http://www.ensembl.org/id/ENST00000335304
Ensembl	ENST00000415389	http://www.ensembl.org/id/ENST00000415389
Ensembl	ENST00000425359	http://www.ensembl.org/id/ENST00000425359
Ensembl	ENST00000436361	http://www.ensembl.org/id/ENST00000436361
Ensembl	ENST00000440596	http://www.ensembl.org/id/ENST00000440596
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0004993	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004993
GO_function	GO:0005232	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005232
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.370	http://www.cathdb.info/version/latest/superfamily/1.20.120.370
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	HTR3E	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=HTR3E
GeneID	285242	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=285242
GeneTree	ENSGT00790000122957	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00790000122957
HGNC	HGNC:24005	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:24005
HOGENOM	HOG000241519	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000241519&db=HOGENOM6
HOVERGEN	HBG106638	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG106638&db=HOVERGEN
HPA	HPA049764	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA049764
InParanoid	A5X5Y0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=A5X5Y0
IntAct	A5X5Y0	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=A5X5Y0*
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
InterPro	IPR027361	http://www.ebi.ac.uk/interpro/entry/IPR027361
Jabion	285242	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=285242
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:285242	http://www.genome.jp/dbget-bin/www_bget?hsa:285242
KEGG_Orthology	KO:K04819	http://www.genome.jp/dbget-bin/www_bget?KO:K04819
KEGG_Pathway	ko04726	http://www.genome.jp/kegg-bin/show_pathway?ko04726
MIM	610123	http://www.ncbi.nlm.nih.gov/omim/610123
OMA	SYREHRV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SYREHRV
OrthoDB	EOG091G042C	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G042C
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:5HT3E_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:5HT3E_HUMAN
PSORT-B	swissprot:5HT3E_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:5HT3E_HUMAN
PSORT2	swissprot:5HT3E_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:5HT3E_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA134900226	http://www.pharmgkb.org/do/serve?objId=PA134900226&objCls=Gene
Phobius	swissprot:5HT3E_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:5HT3E_HUMAN
PhylomeDB	A5X5Y0	http://phylomedb.org/?seqid=A5X5Y0
ProteinModelPortal	A5X5Y0	http://www.proteinmodelportal.org/query/uniprot/A5X5Y0
PubMed	12801637	http://www.ncbi.nlm.nih.gov/pubmed/12801637
PubMed	14597179	http://www.ncbi.nlm.nih.gov/pubmed/14597179
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	17392525	http://www.ncbi.nlm.nih.gov/pubmed/17392525
PubMed	19012743	http://www.ncbi.nlm.nih.gov/pubmed/19012743
Reactome	R-HSA-975298	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-975298
RefSeq	NP_001243542	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243542
RefSeq	NP_001243543	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243543
RefSeq	NP_872395	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_872395
RefSeq	NP_938055	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_938055
RefSeq	NP_938056	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_938056
STRING	9606.ENSP00000335511	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000335511&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
UCSC	uc003fml	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003fml&org=rat
UniGene	Hs.449179	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.449179
UniProtKB	5HT3E_HUMAN	http://www.uniprot.org/uniprot/5HT3E_HUMAN
UniProtKB-AC	A5X5Y0	http://www.uniprot.org/uniprot/A5X5Y0
charge	swissprot:5HT3E_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:5HT3E_HUMAN
eggNOG	ENOG410XQGR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQGR
eggNOG	KOG3645	http://eggnogapi.embl.de/nog_data/html/tree/KOG3645
epestfind	swissprot:5HT3E_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:5HT3E_HUMAN
garnier	swissprot:5HT3E_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:5HT3E_HUMAN
helixturnhelix	swissprot:5HT3E_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:5HT3E_HUMAN
hmoment	swissprot:5HT3E_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:5HT3E_HUMAN
iep	swissprot:5HT3E_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:5HT3E_HUMAN
inforesidue	swissprot:5HT3E_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:5HT3E_HUMAN
neXtProt	NX_A5X5Y0	http://www.nextprot.org/db/entry/NX_A5X5Y0
octanol	swissprot:5HT3E_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:5HT3E_HUMAN
pepcoil	swissprot:5HT3E_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:5HT3E_HUMAN
pepdigest	swissprot:5HT3E_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:5HT3E_HUMAN
pepinfo	swissprot:5HT3E_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:5HT3E_HUMAN
pepnet	swissprot:5HT3E_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:5HT3E_HUMAN
pepstats	swissprot:5HT3E_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:5HT3E_HUMAN
pepwheel	swissprot:5HT3E_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:5HT3E_HUMAN
pepwindow	swissprot:5HT3E_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:5HT3E_HUMAN
sigcleave	swissprot:5HT3E_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:5HT3E_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GBRG2_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P18507-1; Sequence=Displayed; Name=2; IsoId=P18507-2; Sequence=VSP_041124; Name=3; IsoId=P18507-3; Sequence=VSP_047323, VSP_041124; Note=No experimental confirmation available.; 
# AltName	GBRG2_HUMAN	GABA(A) receptor subunit gamma-2
# BioGrid	108840	13
# CCDS	CCDS4358	-. [P18507-1]
# CCDS	CCDS4359	-. [P18507-2]
# CCDS	CCDS47333	-. [P18507-3]
# ChiTaRS	GABRG2	human
# DISEASE	GBRG2_HUMAN	Epilepsy, childhood absence 2 (ECA2) [MIM 607681]  A subtype of idiopathic generalized epilepsy characterized by an onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. Tonic-clonic seizures often develop in adolescence. Some individuals manifest febrile seizures. Absence seizures may either remit or persist into adulthood. {ECO 0000269|PubMed 11326275}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# DISEASE	GBRG2_HUMAN	Febrile seizures, familial, 8 (FEB8) [MIM 611277]  Seizures associated with febrile episodes in childhood without any evidence of intracranial infection or defined pathologic or traumatic cause. It is a common condition, affecting 2-5% of children aged 3 months to 5 years. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy. {ECO 0000269|PubMed 16924025}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	GBRG2_HUMAN	Generalized epilepsy with febrile seizures plus 3 (GEFS+3) [MIM 611277]  A rare autosomal dominant, familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. This disease combines febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity. {ECO 0000269|PubMed 11326274}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00186	Lorazepam
# DrugBank	DB00189	Ethchlorvynol
# DrugBank	DB00228	Enflurane
# DrugBank	DB00231	Temazepam
# DrugBank	DB00237	Butabarbital
# DrugBank	DB00241	Butalbital
# DrugBank	DB00273	Topiramate
# DrugBank	DB00292	Etomidate
# DrugBank	DB00306	Talbutal
# DrugBank	DB00312	Pentobarbital
# DrugBank	DB00334	Olanzapine
# DrugBank	DB00349	Clobazam
# DrugBank	DB00371	Meprobamate
# DrugBank	DB00402	Eszopiclone
# DrugBank	DB00404	Alprazolam
# DrugBank	DB00475	Chlordiazepoxide
# DrugBank	DB00543	Amoxapine
# DrugBank	DB00546	Adinazolam
# DrugBank	DB00628	Clorazepate
# DrugBank	DB00659	Acamprosate
# DrugBank	DB00683	Midazolam
# DrugBank	DB00690	Flurazepam
# DrugBank	DB00753	Isoflurane
# DrugBank	DB00794	Primidone
# DrugBank	DB00801	Halazepam
# DrugBank	DB00818	Propofol
# DrugBank	DB00829	Diazepam
# DrugBank	DB00842	Oxazepam
# DrugBank	DB00897	Triazolam
# DrugBank	DB01028	Methoxyflurane
# DrugBank	DB01049	Ergoloid mesylate
# DrugBank	DB01068	Clonazepam
# DrugBank	DB01107	Methyprylon
# DrugBank	DB01159	Halothane
# DrugBank	DB01189	Desflurane
# DrugBank	DB01205	Flumazenil
# DrugBank	DB01215	Estazolam
# DrugBank	DB01236	Sevoflurane
# DrugBank	DB01381	Ginkgo biloba
# DrugBank	DB01437	Glutethimide
# DrugBank	DB01558	Bromazepam
# DrugBank	DB01559	Clotiazepam
# DrugBank	DB01567	Fludiazepam
# DrugBank	DB01588	Prazepam
# DrugBank	DB01589	Quazepam
# DrugBank	DB01594	Cinolazepam
# DrugBank	DB01595	Nitrazepam
# Ensembl	ENST00000356592	ENSP00000349000; ENSG00000113327. [P18507-2]
# Ensembl	ENST00000361925	ENSP00000354651; ENSG00000113327. [P18507-1]
# Ensembl	ENST00000414552	ENSP00000410732; ENSG00000113327. [P18507-3]
# ExpressionAtlas	P18507	baseline and differential
# FUNCTION	GBRG2_HUMAN	Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel. {ECO 0000269|PubMed 2538761}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; ISS:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030424	axon; IEA:Ensembl.
# GO_component	GO:0032590	dendrite membrane; ISS:BHF-UCL.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:1902711	GABA-A receptor complex; ISS:UniProtKB.
# GO_function	GO:0004890	GABA-A receptor activity; ISS:UniProtKB.
# GO_function	GO:0005230	extracellular ligand-gated ion channel activity; IEA:InterPro.
# GO_function	GO:0005254	chloride channel activity; ISS:UniProtKB.
# GO_function	GO:0008503	benzodiazepine receptor activity; TAS:ProtInc.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007214	gamma-aminobutyric acid signaling pathway; TAS:ProtInc.
# GO_process	GO:0009791	post-embryonic development; IEA:Ensembl.
# GO_process	GO:0030534	adult behavior; IEA:Ensembl.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0051932	synaptic transmission, GABAergic; ISS:BHF-UCL.
# GO_process	GO:0071420	cellular response to histamine; ISS:UniProtKB.
# GO_process	GO:1902476	chloride transmembrane transport; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.70.170.10	-; 1.
# Genevisible	P18507	HS
# HGNC	HGNC:4087	GABRG2
# InterPro	IPR005437	GABBAg_rcpt
# InterPro	IPR005439	GABBAg2_rcpt
# InterPro	IPR006028	GABAA/Glycine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00783	[Nervous system disease; Epilepsy] Dravet syndrome/ Severe myoclonic epilepsy in infancy (SMEI)
# KEGG_Disease	H00808	[Nervous system disease] Familial infantile myoclonic epilepsy (FIME)
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04727	GABAergic synapse
# KEGG_Pathway	ko05032	Morphine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# MIM	137164	gene
# MIM	604233	phenotype
# MIM	607681	phenotype
# MIM	611277	phenotype
# MISCELLANEOUS	GBRG2_HUMAN	This subunit carries the benzodiazepine binding site. 
# Organism	GBRG2_HUMAN	Homo sapiens (Human)
# Orphanet	33069	Dravet syndrome
# Orphanet	36387	Generalized epilepsy with febrile seizures-plus
# Orphanet	64280	Childhood absence epilepsy
# PANTHER	PTHR18945	PTHR18945; 2
# PIR	S03905	S03905
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00253	GABAARECEPTR
# PRINTS	PR01620	GABAARGAMMA
# PRINTS	PR01622	GABAARGAMMA2
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# PTM	GBRG2_HUMAN	Palmitoylated by ZDHHC3/GODZ; which may affect presynaptic clustering and/or cell surface stability. {ECO 0000250}. 
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-112314	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
# Reactome	R-HSA-975298	Ligand-gated ion channel transport
# Reactome	R-HSA-977441	GABA A receptor activation
# RecName	GBRG2_HUMAN	Gamma-aminobutyric acid receptor subunit gamma-2
# RefSeq	NP_000807	NM_000816.3. [P18507-1]
# RefSeq	NP_944493	NM_198903.2. [P18507-3]
# RefSeq	NP_944494	NM_198904.2. [P18507-2]
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	GBRG2_HUMAN	Cell junction, synapse, postsynaptic cell membrane {ECO 0000269|PubMed 2538761}; Multi-pass membrane protein {ECO 0000269|PubMed 2538761}. Cell membrane {ECO 0000269|PubMed 2538761}; Multi-pass membrane protein {ECO 0000269|PubMed 2538761}. Cell projection, dendrite {ECO 0000250|UniProtKB P22723}. Cytoplasmic vesicle membrane {ECO 0000250|UniProtKB P18508}. 
# SUBUNIT	GBRG2_HUMAN	Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains (PubMed 2538761). Interacts with GABARAP (PubMed 9892355). Interacts with KIF21B (By similarity). {ECO 0000250|UniProtKB P18508, ECO 0000269|PubMed 2538761, ECO 0000269|PubMed 9892355}. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TCDB	1.A.9.5	the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family
# TIGRFAMs	TIGR00860	LIC
# TopDownProteomics	P18507-2	-. [P18507-2]
# UCSC	uc003lyy	human. [P18507-1]
# WEB RESOURCE	GBRG2_HUMAN	Name=Protein Spotlight; Note=Forbidden fruit - Issue 56 of March 2005; URL="http //web.expasy.org/spotlight/back_issues/056";
BLAST	swissprot:GBRG2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GBRG2_HUMAN
BioCyc	ZFISH:ENSG00000113327-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000113327-MONOMER
COXPRESdb	2566	http://coxpresdb.jp/data/gene/2566.shtml
CleanEx	HS_GABRG2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GABRG2
DOI	10.1038/16264	http://dx.doi.org/10.1038/16264
DOI	10.1038/338582a0	http://dx.doi.org/10.1038/338582a0
DOI	10.1038/88254	http://dx.doi.org/10.1038/88254
DOI	10.1038/88259	http://dx.doi.org/10.1038/88259
DOI	10.1038/jhg.2010.47	http://dx.doi.org/10.1038/jhg.2010.47
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1460-9568.2011.07767.x	http://dx.doi.org/10.1111/j.1460-9568.2011.07767.x
DOI	10.1111/j.1471-4159.1993.tb03243.x	http://dx.doi.org/10.1111/j.1471-4159.1993.tb03243.x
DOI	10.1212/01.wnl.0000230145.73496.a2	http://dx.doi.org/10.1212/01.wnl.0000230145.73496.a2
DrugBank	DB00186	http://www.drugbank.ca/drugs/DB00186
DrugBank	DB00189	http://www.drugbank.ca/drugs/DB00189
DrugBank	DB00228	http://www.drugbank.ca/drugs/DB00228
DrugBank	DB00231	http://www.drugbank.ca/drugs/DB00231
DrugBank	DB00237	http://www.drugbank.ca/drugs/DB00237
DrugBank	DB00241	http://www.drugbank.ca/drugs/DB00241
DrugBank	DB00273	http://www.drugbank.ca/drugs/DB00273
DrugBank	DB00292	http://www.drugbank.ca/drugs/DB00292
DrugBank	DB00306	http://www.drugbank.ca/drugs/DB00306
DrugBank	DB00312	http://www.drugbank.ca/drugs/DB00312
DrugBank	DB00334	http://www.drugbank.ca/drugs/DB00334
DrugBank	DB00349	http://www.drugbank.ca/drugs/DB00349
DrugBank	DB00371	http://www.drugbank.ca/drugs/DB00371
DrugBank	DB00402	http://www.drugbank.ca/drugs/DB00402
DrugBank	DB00404	http://www.drugbank.ca/drugs/DB00404
DrugBank	DB00475	http://www.drugbank.ca/drugs/DB00475
DrugBank	DB00543	http://www.drugbank.ca/drugs/DB00543
DrugBank	DB00546	http://www.drugbank.ca/drugs/DB00546
DrugBank	DB00628	http://www.drugbank.ca/drugs/DB00628
DrugBank	DB00659	http://www.drugbank.ca/drugs/DB00659
DrugBank	DB00683	http://www.drugbank.ca/drugs/DB00683
DrugBank	DB00690	http://www.drugbank.ca/drugs/DB00690
DrugBank	DB00753	http://www.drugbank.ca/drugs/DB00753
DrugBank	DB00794	http://www.drugbank.ca/drugs/DB00794
DrugBank	DB00801	http://www.drugbank.ca/drugs/DB00801
DrugBank	DB00818	http://www.drugbank.ca/drugs/DB00818
DrugBank	DB00829	http://www.drugbank.ca/drugs/DB00829
DrugBank	DB00842	http://www.drugbank.ca/drugs/DB00842
DrugBank	DB00897	http://www.drugbank.ca/drugs/DB00897
DrugBank	DB01028	http://www.drugbank.ca/drugs/DB01028
DrugBank	DB01049	http://www.drugbank.ca/drugs/DB01049
DrugBank	DB01068	http://www.drugbank.ca/drugs/DB01068
DrugBank	DB01107	http://www.drugbank.ca/drugs/DB01107
DrugBank	DB01159	http://www.drugbank.ca/drugs/DB01159
DrugBank	DB01189	http://www.drugbank.ca/drugs/DB01189
DrugBank	DB01205	http://www.drugbank.ca/drugs/DB01205
DrugBank	DB01215	http://www.drugbank.ca/drugs/DB01215
DrugBank	DB01236	http://www.drugbank.ca/drugs/DB01236
DrugBank	DB01381	http://www.drugbank.ca/drugs/DB01381
DrugBank	DB01437	http://www.drugbank.ca/drugs/DB01437
DrugBank	DB01558	http://www.drugbank.ca/drugs/DB01558
DrugBank	DB01559	http://www.drugbank.ca/drugs/DB01559
DrugBank	DB01567	http://www.drugbank.ca/drugs/DB01567
DrugBank	DB01588	http://www.drugbank.ca/drugs/DB01588
DrugBank	DB01589	http://www.drugbank.ca/drugs/DB01589
DrugBank	DB01594	http://www.drugbank.ca/drugs/DB01594
DrugBank	DB01595	http://www.drugbank.ca/drugs/DB01595
EMBL	AC008611	http://www.ebi.ac.uk/ena/data/view/AC008611
EMBL	AC091926	http://www.ebi.ac.uk/ena/data/view/AC091926
EMBL	AC091984	http://www.ebi.ac.uk/ena/data/view/AC091984
EMBL	AF165124	http://www.ebi.ac.uk/ena/data/view/AF165124
EMBL	BC059389	http://www.ebi.ac.uk/ena/data/view/BC059389
EMBL	BC069348	http://www.ebi.ac.uk/ena/data/view/BC069348
EMBL	BC074795	http://www.ebi.ac.uk/ena/data/view/BC074795
EMBL	X15376	http://www.ebi.ac.uk/ena/data/view/X15376
Ensembl	ENST00000356592	http://www.ensembl.org/id/ENST00000356592
Ensembl	ENST00000361925	http://www.ensembl.org/id/ENST00000361925
Ensembl	ENST00000414552	http://www.ensembl.org/id/ENST00000414552
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030424	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030424
GO_component	GO:0032590	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032590
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_component	GO:1902711	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902711
GO_function	GO:0004890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004890
GO_function	GO:0005230	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005230
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0008503	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008503
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007214	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007214
GO_process	GO:0009791	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009791
GO_process	GO:0030534	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030534
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0051932	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051932
GO_process	GO:0071420	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071420
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	GABRG2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GABRG2
GeneID	2566	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2566
GeneTree	ENSGT00760000119010	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119010
HGNC	HGNC:4087	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4087
HOGENOM	HOG000231337	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231337&db=HOGENOM6
HOVERGEN	HBG051707	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051707&db=HOVERGEN
InParanoid	P18507	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P18507
InterPro	IPR005437	http://www.ebi.ac.uk/interpro/entry/IPR005437
InterPro	IPR005439	http://www.ebi.ac.uk/interpro/entry/IPR005439
InterPro	IPR006028	http://www.ebi.ac.uk/interpro/entry/IPR006028
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
Jabion	2566	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2566
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00783	http://www.genome.jp/dbget-bin/www_bget?H00783
KEGG_Disease	H00808	http://www.genome.jp/dbget-bin/www_bget?H00808
KEGG_Gene	hsa:2566	http://www.genome.jp/dbget-bin/www_bget?hsa:2566
KEGG_Orthology	KO:K05186	http://www.genome.jp/dbget-bin/www_bget?KO:K05186
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
KEGG_Pathway	ko05032	http://www.genome.jp/kegg-bin/show_pathway?ko05032
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
MIM	137164	http://www.ncbi.nlm.nih.gov/omim/137164
MIM	604233	http://www.ncbi.nlm.nih.gov/omim/604233
MIM	607681	http://www.ncbi.nlm.nih.gov/omim/607681
MIM	611277	http://www.ncbi.nlm.nih.gov/omim/611277
OMA	YPGFTSQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YPGFTSQ
Orphanet	33069	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=33069
Orphanet	36387	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=36387
Orphanet	64280	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=64280
OrthoDB	EOG091G0805	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0805
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00253	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00253
PRINTS	PR01620	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01620
PRINTS	PR01622	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01622
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:GBRG2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GBRG2_HUMAN
PSORT-B	swissprot:GBRG2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GBRG2_HUMAN
PSORT2	swissprot:GBRG2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GBRG2_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA28501	http://www.pharmgkb.org/do/serve?objId=PA28501&objCls=Gene
Phobius	swissprot:GBRG2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GBRG2_HUMAN
PhylomeDB	P18507	http://phylomedb.org/?seqid=P18507
ProteinModelPortal	P18507	http://www.proteinmodelportal.org/query/uniprot/P18507
PubMed	11326274	http://www.ncbi.nlm.nih.gov/pubmed/11326274
PubMed	11326275	http://www.ncbi.nlm.nih.gov/pubmed/11326275
PubMed	11328646	http://www.ncbi.nlm.nih.gov/pubmed/11328646
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16924025	http://www.ncbi.nlm.nih.gov/pubmed/16924025
PubMed	20485450	http://www.ncbi.nlm.nih.gov/pubmed/20485450
PubMed	21714819	http://www.ncbi.nlm.nih.gov/pubmed/21714819
PubMed	2538761	http://www.ncbi.nlm.nih.gov/pubmed/2538761
PubMed	8382267	http://www.ncbi.nlm.nih.gov/pubmed/8382267
PubMed	9892355	http://www.ncbi.nlm.nih.gov/pubmed/9892355
Reactome	R-HSA-112314	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112314
Reactome	R-HSA-975298	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-975298
Reactome	R-HSA-977441	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-977441
RefSeq	NP_000807	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000807
RefSeq	NP_944493	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_944493
RefSeq	NP_944494	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_944494
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TCDB	1.A.9.5	http://www.tcdb.org/search/result.php?tc=1.A.9.5
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc003lyy	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003lyy&org=rat
UniGene	Hs.7195	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.7195
UniProtKB	GBRG2_HUMAN	http://www.uniprot.org/uniprot/GBRG2_HUMAN
UniProtKB-AC	P18507	http://www.uniprot.org/uniprot/P18507
charge	swissprot:GBRG2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GBRG2_HUMAN
epestfind	swissprot:GBRG2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GBRG2_HUMAN
garnier	swissprot:GBRG2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GBRG2_HUMAN
helixturnhelix	swissprot:GBRG2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GBRG2_HUMAN
hmoment	swissprot:GBRG2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GBRG2_HUMAN
iep	swissprot:GBRG2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GBRG2_HUMAN
inforesidue	swissprot:GBRG2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GBRG2_HUMAN
neXtProt	NX_P18507	http://www.nextprot.org/db/entry/NX_P18507
octanol	swissprot:GBRG2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GBRG2_HUMAN
pepcoil	swissprot:GBRG2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GBRG2_HUMAN
pepdigest	swissprot:GBRG2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GBRG2_HUMAN
pepinfo	swissprot:GBRG2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GBRG2_HUMAN
pepnet	swissprot:GBRG2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GBRG2_HUMAN
pepstats	swissprot:GBRG2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GBRG2_HUMAN
pepwheel	swissprot:GBRG2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GBRG2_HUMAN
pepwindow	swissprot:GBRG2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GBRG2_HUMAN
sigcleave	swissprot:GBRG2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GBRG2_HUMAN
## Database	ID	URL or Descriptions
# AltName	S28A2_HUMAN	Concentrative nucleoside transporter 2
# AltName	S28A2_HUMAN	Na(+)/nucleoside cotransporter 2
# AltName	S28A2_HUMAN	Sodium-coupled nucleoside transporter 2
# AltName	S28A2_HUMAN	Sodium/purine nucleoside co-transporter
# AltName	S28A2_HUMAN	Solute carrier family 28 member 2
# DrugBank	DB01033	Mercaptopurine
# ENZYME REGULATION	S28A2_HUMAN	Inhibited by formycin B. 
# Ensembl	ENST00000347644	ENSP00000315006; ENSG00000137860
# ExpressionAtlas	O43868	baseline and differential
# FUNCTION	S28A2_HUMAN	Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_function	GO:0015211	purine nucleoside transmembrane transporter activity; TAS:ProtInc.
# GO_function	S28A2_HUMAN	GO 0005415 nucleoside sodium symporter activity; IBA GO_Central.
# GO_process	GO:0006139	nucleobase-containing compound metabolic process; TAS:ProtInc.
# GO_process	GO:0015860	purine nucleoside transmembrane transport; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	O43868	HS
# HGNC	HGNC:11002	SLC28A2
# InterPro	IPR002668	CNT_N_dom
# InterPro	IPR008276	C_nuclsd_transpt
# InterPro	IPR011642	Gate_dom
# InterPro	IPR011657	CNT_C_dom
# InterPro	IPR018270	C_nuclsd_transpt_met_bac
# InterPro	IPR030212	CNT1/CNT2
# KEGG_Brite	ko02001	Solute carrier family
# MIM	606208	gene
# Organism	S28A2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10590	PTHR10590
# PANTHER	PTHR10590:SF11	PTHR10590:SF11
# Pfam	PF01773	Nucleos_tra2_N
# Pfam	PF07662	Nucleos_tra2_C
# Pfam	PF07670	Gate
# Proteomes	UP000005640	Chromosome 15
# Reactome	R-HSA-83936	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
# RecName	S28A2_HUMAN	Sodium/nucleoside cotransporter 2
# RefSeq	NP_004203	NM_004212.3
# RefSeq	XP_011520500	XM_011522198.2
# SIMILARITY	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S28A2_HUMAN	Membrane; Multi-pass membrane protein. 
# TCDB	2.A.41.2	the concentrative nucleoside transporter (cnt) family
# TIGRFAMs	TIGR00804	nupC
# TISSUE SPECIFICITY	S28A2_HUMAN	Expressed in heart and skeletal muscle followed by liver, kidney, intestine, pancreas, placenta and brain. Weak expression in lung. 
# UCSC	uc001zva	human
# eggNOG	COG1972	LUCA
# eggNOG	KOG3747	Eukaryota
BLAST	swissprot:S28A2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S28A2_HUMAN
BioCyc	ZFISH:ENSG00000137860-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000137860-MONOMER
COXPRESdb	9153	http://coxpresdb.jp/data/gene/9153.shtml
CleanEx	HS_SLC28A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC28A2
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.274.35.24475	http://dx.doi.org/10.1074/jbc.274.35.24475
DOI	10.1097/01213011-200502000-00004	http://dx.doi.org/10.1097/01213011-200502000-00004
DOI	10.1097/FPC.0b013e3281c10e41	http://dx.doi.org/10.1097/FPC.0b013e3281c10e41
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.3109/09687689709044322	http://dx.doi.org/10.3109/09687689709044322
DrugBank	DB01033	http://www.drugbank.ca/drugs/DB01033
EMBL	AF036109	http://www.ebi.ac.uk/ena/data/view/AF036109
EMBL	AK291974	http://www.ebi.ac.uk/ena/data/view/AK291974
EMBL	BC093737	http://www.ebi.ac.uk/ena/data/view/BC093737
EMBL	U84392	http://www.ebi.ac.uk/ena/data/view/U84392
Ensembl	ENST00000347644	http://www.ensembl.org/id/ENST00000347644
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0005415	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005415
GO_function	GO:0015211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015211
GO_process	GO:0006139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006139
GO_process	GO:0015860	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015860
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC28A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC28A2
GeneID	9153	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9153
GeneTree	ENSGT00390000016025	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000016025
HGNC	HGNC:11002	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11002
HOGENOM	HOG000267658	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267658&db=HOGENOM6
HOVERGEN	HBG054073	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054073&db=HOVERGEN
HPA	HPA046068	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA046068
HPA	HPA055623	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA055623
InParanoid	O43868	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O43868
IntAct	O43868	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O43868*
InterPro	IPR002668	http://www.ebi.ac.uk/interpro/entry/IPR002668
InterPro	IPR008276	http://www.ebi.ac.uk/interpro/entry/IPR008276
InterPro	IPR011642	http://www.ebi.ac.uk/interpro/entry/IPR011642
InterPro	IPR011657	http://www.ebi.ac.uk/interpro/entry/IPR011657
InterPro	IPR018270	http://www.ebi.ac.uk/interpro/entry/IPR018270
InterPro	IPR030212	http://www.ebi.ac.uk/interpro/entry/IPR030212
Jabion	9153	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9153
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:9153	http://www.genome.jp/dbget-bin/www_bget?hsa:9153
KEGG_Orthology	KO:K11536	http://www.genome.jp/dbget-bin/www_bget?KO:K11536
MIM	606208	http://www.ncbi.nlm.nih.gov/omim/606208
OMA	FCKTHAS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FCKTHAS
OrthoDB	EOG091G05D5	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05D5
PANTHER	PTHR10590	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10590
PANTHER	PTHR10590:SF11	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10590:SF11
PSORT	swissprot:S28A2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S28A2_HUMAN
PSORT-B	swissprot:S28A2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S28A2_HUMAN
PSORT2	swissprot:S28A2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S28A2_HUMAN
Pfam	PF01773	http://pfam.xfam.org/family/PF01773
Pfam	PF07662	http://pfam.xfam.org/family/PF07662
Pfam	PF07670	http://pfam.xfam.org/family/PF07670
PharmGKB	PA386	http://www.pharmgkb.org/do/serve?objId=PA386&objCls=Gene
Phobius	swissprot:S28A2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S28A2_HUMAN
PhylomeDB	O43868	http://phylomedb.org/?seqid=O43868
ProteinModelPortal	O43868	http://www.proteinmodelportal.org/query/uniprot/O43868
PubMed	10087507	http://www.ncbi.nlm.nih.gov/pubmed/10087507
PubMed	10455109	http://www.ncbi.nlm.nih.gov/pubmed/10455109
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15861032	http://www.ncbi.nlm.nih.gov/pubmed/15861032
PubMed	17700367	http://www.ncbi.nlm.nih.gov/pubmed/17700367
PubMed	9435697	http://www.ncbi.nlm.nih.gov/pubmed/9435697
Reactome	R-HSA-83936	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-83936
RefSeq	NP_004203	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004203
RefSeq	XP_011520500	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011520500
STRING	9606.ENSP00000315006	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000315006&targetmode=cogs
TCDB	2.A.41.2	http://www.tcdb.org/search/result.php?tc=2.A.41.2
TIGRFAMs	TIGR00804	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00804
UCSC	uc001zva	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001zva&org=rat
UniGene	Hs.367833	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.367833
UniProtKB	S28A2_HUMAN	http://www.uniprot.org/uniprot/S28A2_HUMAN
UniProtKB-AC	O43868	http://www.uniprot.org/uniprot/O43868
charge	swissprot:S28A2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S28A2_HUMAN
eggNOG	COG1972	http://eggnogapi.embl.de/nog_data/html/tree/COG1972
eggNOG	KOG3747	http://eggnogapi.embl.de/nog_data/html/tree/KOG3747
epestfind	swissprot:S28A2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S28A2_HUMAN
garnier	swissprot:S28A2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S28A2_HUMAN
helixturnhelix	swissprot:S28A2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S28A2_HUMAN
hmoment	swissprot:S28A2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S28A2_HUMAN
iep	swissprot:S28A2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S28A2_HUMAN
inforesidue	swissprot:S28A2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S28A2_HUMAN
neXtProt	NX_O43868	http://www.nextprot.org/db/entry/NX_O43868
octanol	swissprot:S28A2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S28A2_HUMAN
pepcoil	swissprot:S28A2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S28A2_HUMAN
pepdigest	swissprot:S28A2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S28A2_HUMAN
pepinfo	swissprot:S28A2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S28A2_HUMAN
pepnet	swissprot:S28A2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S28A2_HUMAN
pepstats	swissprot:S28A2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S28A2_HUMAN
pepwheel	swissprot:S28A2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S28A2_HUMAN
pepwindow	swissprot:S28A2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S28A2_HUMAN
sigcleave	swissprot:S28A2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S28A2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CNGA3_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q16281-1; Sequence=Displayed; Name=2; IsoId=Q16281-2; Sequence=VSP_042525; Note=No experimental confirmation available.; Name=3; IsoId=Q16281-3; Sequence=VSP_057075; Note=No experimental confirmation available.; 
# AltName	CNGA3_HUMAN	Cone photoreceptor cGMP-gated channel subunit alpha
# AltName	CNGA3_HUMAN	Cyclic nucleotide-gated channel alpha-3
# BioGrid	107661	25
# CCDS	CCDS2034	-. [Q16281-1]
# CCDS	CCDS42719	-. [Q16281-2]
# DISEASE	CNGA3_HUMAN	Achromatopsia 2 (ACHM2) [MIM 216900]  An ocular stationary disorder due to the absence of functioning cone photoreceptors in the retina. It is characterized by total colorblindness, low visual acuity, photophobia and nystagmus. {ECO 0000269|PubMed 11536077, ECO 0000269|PubMed 14757870, ECO 0000269|PubMed 15712225, ECO 0000269|PubMed 18521937, ECO 0000269|PubMed 24903488, ECO 0000269|PubMed 26493561, ECO 0000269|PubMed 9662398}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	CNGA3_HUMAN	The C-terminal coiled-coil domain mediates homotrimerization of CNGA subunits. 
# Ensembl	ENST00000272602	ENSP00000272602; ENSG00000144191. [Q16281-1]
# Ensembl	ENST00000393504	ENSP00000377140; ENSG00000144191. [Q16281-1]
# Ensembl	ENST00000409937	ENSP00000386761; ENSG00000144191. [Q16281-3]
# Ensembl	ENST00000436404	ENSP00000410070; ENSG00000144191. [Q16281-2]
# FUNCTION	CNGA3_HUMAN	Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. {ECO 0000250, ECO 0000269|PubMed 10888875}. 
# GO_component	GO:0005737	cytoplasm; IEA:Ensembl.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0030425	dendrite; IEA:Ensembl.
# GO_component	GO:0042622	photoreceptor outer segment membrane; IEA:Ensembl.
# GO_component	GO:0043204	perikaryon; IEA:Ensembl.
# GO_component	GO:1902495	transmembrane transporter complex; IDA:UniProtKB.
# GO_function	GO:0005222	intracellular cAMP activated cation channel activity; IBA:GO_Central.
# GO_function	GO:0005223	intracellular cGMP activated cation channel activity; IMP:UniProtKB.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IBA:GO_Central.
# GO_function	GO:0015276	ligand-gated ion channel activity; TAS:ProtInc.
# GO_function	GO:0030553	cGMP binding; IMP:UniProtKB.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006812	cation transport; IMP:UniProtKB.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0007601	visual perception; TAS:ProtInc.
# GO_process	GO:0031960	response to corticosteroid; IEA:Ensembl.
# GO_process	GO:0032026	response to magnesium ion; IEA:Ensembl.
# GO_process	GO:0042391	regulation of membrane potential; IBA:GO_Central.
# GO_process	GO:0051591	response to cAMP; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# Gene3D	2.60.120.10	-; 1.
# Genevisible	Q16281	HS
# HGNC	HGNC:2150	CNGA3
# InterPro	IPR000595	cNMP-bd_dom
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR014710	RmlC-like_jellyroll
# InterPro	IPR018488	cNMP-bd_CS
# InterPro	IPR018490	cNMP-bd-like
# InterPro	IPR032406	CLZ_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00971	[Eye disease] Rod monochromacy
# KEGG_Pathway	ko04740	Olfactory transduction
# MIM	216900	phenotype
# MIM	600053	gene
# Organism	CNGA3_HUMAN	Homo sapiens (Human)
# Orphanet	1872	Cone rod dystrophy
# Orphanet	49382	Achromatopsia
# PDB	3SWY	X-ray; 1.90 A; A/B/C=626-669
# PIR	I78560	I78560
# PIR	S74179	S74179
# PROSITE	PS00888	CNMP_BINDING_1
# PROSITE	PS00889	CNMP_BINDING_2
# PROSITE	PS50042	CNMP_BINDING_3
# Pfam	PF00027	cNMP_binding
# Pfam	PF00520	Ion_trans
# Pfam	PF16526	CLZ
# Proteomes	UP000005640	Chromosome 2
# RecName	CNGA3_HUMAN	Cyclic nucleotide-gated cation channel alpha-3
# RefSeq	NP_001073347	NM_001079878.1. [Q16281-2]
# RefSeq	NP_001289	NM_001298.2. [Q16281-1]
# SIMILARITY	Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA3 subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 cyclic nucleotide-binding domain. {ECO:0000255|PROSITE-ProRule	PRU00060}. 
# SMART	SM00100	cNMP
# SUBCELLULAR LOCATION	CNGA3_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	CNGA3_HUMAN	Tetramer formed of three CNGA3 and one CNGB3 modulatory subunits. {ECO 0000269|PubMed 10888875, ECO 0000269|PubMed 15134637, ECO 0000269|PubMed 21878911}. 
# SUPFAM	SSF51206	SSF51206
# TCDB	1.A.1.5.12	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	CNGA3_HUMAN	Prominently expressed in retina. 
# UCSC	uc002syt	human. [Q16281-1]
# WEB RESOURCE	CNGA3_HUMAN	Name=Mutations of the CNGA3 gene; Note=Retina International's Scientific Newsletter; URL="http //www.retina-international.org/files/sci-news/cnga3mut.htm";
# eggNOG	ENOG410YWWI	LUCA
# eggNOG	KOG0500	Eukaryota
BLAST	swissprot:CNGA3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CNGA3_HUMAN
BioCyc	ZFISH:ENSG00000144191-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000144191-MONOMER
COXPRESdb	1261	http://coxpresdb.jp/data/gene/1261.shtml
CleanEx	HS_CNGA3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CNGA3
DOI	10.1001/jamaophthalmol.2014.1032	http://dx.doi.org/10.1001/jamaophthalmol.2014.1032
DOI	10.1002/humu.20142	http://dx.doi.org/10.1002/humu.20142
DOI	10.1002/humu.20790	http://dx.doi.org/10.1002/humu.20790
DOI	10.1002/humu.21587	http://dx.doi.org/10.1002/humu.21587
DOI	10.1016/0028-3908(94)90027-2	http://dx.doi.org/10.1016/0028-3908(94)90027-2
DOI	10.1016/S0896-6273(04)00225-9	http://dx.doi.org/10.1016/S0896-6273(04)00225-9
DOI	10.1038/77162	http://dx.doi.org/10.1038/77162
DOI	10.1038/935	http://dx.doi.org/10.1038/935
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ncomms1466	http://dx.doi.org/10.1038/ncomms1466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1056/NEJMoa1206524	http://dx.doi.org/10.1056/NEJMoa1206524
DOI	10.1086/323613	http://dx.doi.org/10.1086/323613
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1460-9568.1997.tb01680.x	http://dx.doi.org/10.1111/j.1460-9568.1997.tb01680.x
DOI	10.1136/jmg.2003.011437	http://dx.doi.org/10.1136/jmg.2003.011437
DOI	10.1152/ajpcell.00490.2004	http://dx.doi.org/10.1152/ajpcell.00490.2004
DOI	10.1186/s12967-015-0694-7	http://dx.doi.org/10.1186/s12967-015-0694-7
EMBL	AC092675	http://www.ebi.ac.uk/ena/data/view/AC092675
EMBL	AF065314	http://www.ebi.ac.uk/ena/data/view/AF065314
EMBL	AK131300	http://www.ebi.ac.uk/ena/data/view/AK131300
EMBL	BC096298	http://www.ebi.ac.uk/ena/data/view/BC096298
EMBL	BC096299	http://www.ebi.ac.uk/ena/data/view/BC096299
EMBL	BC096300	http://www.ebi.ac.uk/ena/data/view/BC096300
EMBL	S76069	http://www.ebi.ac.uk/ena/data/view/S76069
Ensembl	ENST00000272602	http://www.ensembl.org/id/ENST00000272602
Ensembl	ENST00000393504	http://www.ensembl.org/id/ENST00000393504
Ensembl	ENST00000409937	http://www.ensembl.org/id/ENST00000409937
Ensembl	ENST00000436404	http://www.ensembl.org/id/ENST00000436404
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0042622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042622
GO_component	GO:0043204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043204
GO_component	GO:1902495	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902495
GO_function	GO:0005222	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005222
GO_function	GO:0005223	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005223
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_function	GO:0030553	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030553
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006812	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006812
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007601	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007601
GO_process	GO:0031960	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031960
GO_process	GO:0032026	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032026
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0051591	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051591
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
Gene3D	2.60.120.10	http://www.cathdb.info/version/latest/superfamily/2.60.120.10
GeneCards	CNGA3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CNGA3
GeneID	1261	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1261
GeneTree	ENSGT00760000118772	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118772
HGNC	HGNC:2150	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2150
HOGENOM	HOG000007898	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007898&db=HOGENOM6
HOVERGEN	HBG000281	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000281&db=HOVERGEN
InParanoid	Q16281	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q16281
IntAct	Q16281	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q16281*
InterPro	IPR000595	http://www.ebi.ac.uk/interpro/entry/IPR000595
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR014710	http://www.ebi.ac.uk/interpro/entry/IPR014710
InterPro	IPR018488	http://www.ebi.ac.uk/interpro/entry/IPR018488
InterPro	IPR018490	http://www.ebi.ac.uk/interpro/entry/IPR018490
InterPro	IPR032406	http://www.ebi.ac.uk/interpro/entry/IPR032406
Jabion	1261	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1261
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00971	http://www.genome.jp/dbget-bin/www_bget?H00971
KEGG_Gene	hsa:1261	http://www.genome.jp/dbget-bin/www_bget?hsa:1261
KEGG_Orthology	KO:K04950	http://www.genome.jp/dbget-bin/www_bget?KO:K04950
KEGG_Pathway	ko04740	http://www.genome.jp/kegg-bin/show_pathway?ko04740
MIM	216900	http://www.ncbi.nlm.nih.gov/omim/216900
MIM	600053	http://www.ncbi.nlm.nih.gov/omim/600053
OMA	YLWANRK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YLWANRK
Orphanet	1872	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1872
Orphanet	49382	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=49382
OrthoDB	EOG091G03EW	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G03EW
PDB	3SWY	http://www.ebi.ac.uk/pdbe-srv/view/entry/3SWY
PDBsum	3SWY	http://www.ebi.ac.uk/pdbsum/3SWY
PROSITE	PS00888	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00888
PROSITE	PS00889	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00889
PROSITE	PS50042	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50042
PSORT	swissprot:CNGA3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CNGA3_HUMAN
PSORT-B	swissprot:CNGA3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CNGA3_HUMAN
PSORT2	swissprot:CNGA3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CNGA3_HUMAN
Pfam	PF00027	http://pfam.xfam.org/family/PF00027
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF16526	http://pfam.xfam.org/family/PF16526
PharmGKB	PA26660	http://www.pharmgkb.org/do/serve?objId=PA26660&objCls=Gene
Phobius	swissprot:CNGA3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CNGA3_HUMAN
PhylomeDB	Q16281	http://phylomedb.org/?seqid=Q16281
ProteinModelPortal	Q16281	http://www.proteinmodelportal.org/query/uniprot/Q16281
PubMed	10888875	http://www.ncbi.nlm.nih.gov/pubmed/10888875
PubMed	11536077	http://www.ncbi.nlm.nih.gov/pubmed/11536077
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	14757870	http://www.ncbi.nlm.nih.gov/pubmed/14757870
PubMed	15134637	http://www.ncbi.nlm.nih.gov/pubmed/15134637
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15712225	http://www.ncbi.nlm.nih.gov/pubmed/15712225
PubMed	15743887	http://www.ncbi.nlm.nih.gov/pubmed/15743887
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	18521937	http://www.ncbi.nlm.nih.gov/pubmed/18521937
PubMed	21878911	http://www.ncbi.nlm.nih.gov/pubmed/21878911
PubMed	21901789	http://www.ncbi.nlm.nih.gov/pubmed/21901789
PubMed	23033978	http://www.ncbi.nlm.nih.gov/pubmed/23033978
PubMed	24903488	http://www.ncbi.nlm.nih.gov/pubmed/24903488
PubMed	26493561	http://www.ncbi.nlm.nih.gov/pubmed/26493561
PubMed	7532814	http://www.ncbi.nlm.nih.gov/pubmed/7532814
PubMed	9517456	http://www.ncbi.nlm.nih.gov/pubmed/9517456
PubMed	9662398	http://www.ncbi.nlm.nih.gov/pubmed/9662398
RefSeq	NP_001073347	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001073347
RefSeq	NP_001289	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001289
SMART	SM00100	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00100
SMR	Q16281	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q16281
STRING	9606.ENSP00000272602	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000272602&targetmode=cogs
SUPFAM	SSF51206	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51206
TCDB	1.A.1.5.12	http://www.tcdb.org/search/result.php?tc=1.A.1.5.12
UCSC	uc002syt	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002syt&org=rat
UniGene	Hs.234785	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.234785
UniProtKB	CNGA3_HUMAN	http://www.uniprot.org/uniprot/CNGA3_HUMAN
UniProtKB-AC	Q16281	http://www.uniprot.org/uniprot/Q16281
charge	swissprot:CNGA3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CNGA3_HUMAN
eggNOG	ENOG410YWWI	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YWWI
eggNOG	KOG0500	http://eggnogapi.embl.de/nog_data/html/tree/KOG0500
epestfind	swissprot:CNGA3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CNGA3_HUMAN
garnier	swissprot:CNGA3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CNGA3_HUMAN
helixturnhelix	swissprot:CNGA3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CNGA3_HUMAN
hmoment	swissprot:CNGA3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CNGA3_HUMAN
iep	swissprot:CNGA3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CNGA3_HUMAN
inforesidue	swissprot:CNGA3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CNGA3_HUMAN
neXtProt	NX_Q16281	http://www.nextprot.org/db/entry/NX_Q16281
octanol	swissprot:CNGA3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CNGA3_HUMAN
pepcoil	swissprot:CNGA3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CNGA3_HUMAN
pepdigest	swissprot:CNGA3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CNGA3_HUMAN
pepinfo	swissprot:CNGA3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CNGA3_HUMAN
pepnet	swissprot:CNGA3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CNGA3_HUMAN
pepstats	swissprot:CNGA3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CNGA3_HUMAN
pepwheel	swissprot:CNGA3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CNGA3_HUMAN
pepwindow	swissprot:CNGA3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CNGA3_HUMAN
sigcleave	swissprot:CNGA3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CNGA3_HUMAN
## Database	ID	URL or Descriptions
# AltName	COX6C_HUMAN	Cytochrome c oxidase polypeptide VIc
# BioGrid	107738	22
# CDD	cd00927	Cyt_c_Oxidase_VIc
# ChiTaRS	COX6C	human
# DrugBank	DB02659	Cholic Acid
# Ensembl	ENST00000297564	ENSP00000297564; ENSG00000164919
# Ensembl	ENST00000517682	ENSP00000429714; ENSG00000164919
# Ensembl	ENST00000518171	ENSP00000429755; ENSG00000164919
# Ensembl	ENST00000520271	ENSP00000428150; ENSG00000164919
# Ensembl	ENST00000520468	ENSP00000428895; ENSG00000164919
# Ensembl	ENST00000520517	ENSP00000429991; ENSG00000164919
# Ensembl	ENST00000522934	ENSP00000428702; ENSG00000164919
# Ensembl	ENST00000522940	ENSP00000428965; ENSG00000164919
# Ensembl	ENST00000523016	ENSP00000429707; ENSG00000164919
# Ensembl	ENST00000524245	ENSP00000429410; ENSG00000164919
# ExpressionAtlas	P09669	baseline and differential
# FUNCTION	COX6C_HUMAN	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. 
# GO_component	GO:0005739	mitochondrion; IDA:HPA.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0004129	cytochrome-c oxidase activity; IEA:InterPro.
# GO_process	GO:0006091	generation of precursor metabolites and energy; TAS:ProtInc.
# GO_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# Gene3D	4.10.93.10	-; 1.
# Genevisible	P09669	HS
# HGNC	HGNC:2285	COX6C
# IntAct	P09669	25
# InterPro	IPR004204	COX6C
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	124090	gene
# Organism	COX6C_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12916	PTHR12916
# PIR	S01960	OGHU6C
# ProDom	PD015032	Cyt_c_oxidase_su6c
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-5628897	TP53 Regulates Metabolic Genes
# Reactome	R-HSA-611105	Respiratory electron transport
# RecName	COX6C_HUMAN	Cytochrome c oxidase subunit 6C
# RefSeq	NP_004365	NM_004374.3
# RefSeq	XP_016868509	XM_017013020.1
# SIMILARITY	Belongs to the cytochrome c oxidase subunit 6c family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	COX6C_HUMAN	Mitochondrion inner membrane. 
# UCSC	uc003yiy	human
# WEB RESOURCE	COX6C_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/COX6CID251.html";
# eggNOG	ENOG410J83U	Eukaryota
# eggNOG	ENOG41124VH	LUCA
BLAST	swissprot:COX6C_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:COX6C_HUMAN
BioCyc	ZFISH:HS09158-MONOMER	http://biocyc.org/getid?id=ZFISH:HS09158-MONOMER
COXPRESdb	1345	http://coxpresdb.jp/data/gene/1345.shtml
CleanEx	HS_COX6C	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_COX6C
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0908958106	http://dx.doi.org/10.1073/pnas.0908958106
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1093/nar/16.22.10916	http://dx.doi.org/10.1093/nar/16.22.10916
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DrugBank	DB02659	http://www.drugbank.ca/drugs/DB02659
EMBL	AF067636	http://www.ebi.ac.uk/ena/data/view/AF067636
EMBL	AF067637	http://www.ebi.ac.uk/ena/data/view/AF067637
EMBL	AK311791	http://www.ebi.ac.uk/ena/data/view/AK311791
EMBL	BC000187	http://www.ebi.ac.uk/ena/data/view/BC000187
EMBL	BT007007	http://www.ebi.ac.uk/ena/data/view/BT007007
EMBL	CH471060	http://www.ebi.ac.uk/ena/data/view/CH471060
EMBL	X13238	http://www.ebi.ac.uk/ena/data/view/X13238
Ensembl	ENST00000297564	http://www.ensembl.org/id/ENST00000297564
Ensembl	ENST00000517682	http://www.ensembl.org/id/ENST00000517682
Ensembl	ENST00000518171	http://www.ensembl.org/id/ENST00000518171
Ensembl	ENST00000520271	http://www.ensembl.org/id/ENST00000520271
Ensembl	ENST00000520468	http://www.ensembl.org/id/ENST00000520468
Ensembl	ENST00000520517	http://www.ensembl.org/id/ENST00000520517
Ensembl	ENST00000522934	http://www.ensembl.org/id/ENST00000522934
Ensembl	ENST00000522940	http://www.ensembl.org/id/ENST00000522940
Ensembl	ENST00000523016	http://www.ensembl.org/id/ENST00000523016
Ensembl	ENST00000524245	http://www.ensembl.org/id/ENST00000524245
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0004129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004129
GO_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GO_process	GO:0006123	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006123
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
Gene3D	4.10.93.10	http://www.cathdb.info/version/latest/superfamily/4.10.93.10
GeneCards	COX6C	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=COX6C
GeneID	1345	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1345
GeneTree	ENSGT00390000004573	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000004573
HGNC	HGNC:2285	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2285
HOGENOM	HOG000039249	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000039249&db=HOGENOM6
HOVERGEN	HBG051091	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051091&db=HOVERGEN
HPA	CAB016244	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB016244
HPA	HPA014295	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014295
InParanoid	P09669	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09669
IntAct	P09669	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09669*
InterPro	IPR004204	http://www.ebi.ac.uk/interpro/entry/IPR004204
Jabion	1345	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1345
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Gene	hsa:1345	http://www.genome.jp/dbget-bin/www_bget?hsa:1345
KEGG_Orthology	KO:K02268	http://www.genome.jp/dbget-bin/www_bget?KO:K02268
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	124090	http://www.ncbi.nlm.nih.gov/omim/124090
OMA	KPVMRGL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KPVMRGL
OrthoDB	EOG091G10KX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G10KX
PANTHER	PTHR12916	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12916
PSORT	swissprot:COX6C_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:COX6C_HUMAN
PSORT-B	swissprot:COX6C_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:COX6C_HUMAN
PSORT2	swissprot:COX6C_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:COX6C_HUMAN
PharmGKB	PA26802	http://www.pharmgkb.org/do/serve?objId=PA26802&objCls=Gene
Phobius	swissprot:COX6C_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:COX6C_HUMAN
PhylomeDB	P09669	http://phylomedb.org/?seqid=P09669
ProteinModelPortal	P09669	http://www.proteinmodelportal.org/query/uniprot/P09669
PubMed	10072584	http://www.ncbi.nlm.nih.gov/pubmed/10072584
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19892738	http://www.ncbi.nlm.nih.gov/pubmed/19892738
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	2849755	http://www.ncbi.nlm.nih.gov/pubmed/2849755
Reactome	R-HSA-5628897	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5628897
Reactome	R-HSA-611105	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-611105
RefSeq	NP_004365	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004365
RefSeq	XP_016868509	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016868509
SMR	P09669	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09669
STRING	9606.ENSP00000297564	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000297564&targetmode=cogs
UCSC	uc003yiy	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003yiy&org=rat
UniGene	Hs.351875	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.351875
UniProtKB	COX6C_HUMAN	http://www.uniprot.org/uniprot/COX6C_HUMAN
UniProtKB-AC	P09669	http://www.uniprot.org/uniprot/P09669
charge	swissprot:COX6C_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:COX6C_HUMAN
eggNOG	ENOG410J83U	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410J83U
eggNOG	ENOG41124VH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG41124VH
epestfind	swissprot:COX6C_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:COX6C_HUMAN
garnier	swissprot:COX6C_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:COX6C_HUMAN
helixturnhelix	swissprot:COX6C_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:COX6C_HUMAN
hmoment	swissprot:COX6C_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:COX6C_HUMAN
iep	swissprot:COX6C_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:COX6C_HUMAN
inforesidue	swissprot:COX6C_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:COX6C_HUMAN
neXtProt	NX_P09669	http://www.nextprot.org/db/entry/NX_P09669
octanol	swissprot:COX6C_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:COX6C_HUMAN
pepcoil	swissprot:COX6C_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:COX6C_HUMAN
pepdigest	swissprot:COX6C_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:COX6C_HUMAN
pepinfo	swissprot:COX6C_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:COX6C_HUMAN
pepnet	swissprot:COX6C_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:COX6C_HUMAN
pepstats	swissprot:COX6C_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:COX6C_HUMAN
pepwheel	swissprot:COX6C_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:COX6C_HUMAN
pepwindow	swissprot:COX6C_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:COX6C_HUMAN
sigcleave	swissprot:COX6C_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:COX6C_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	MLC1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q15049-1; Sequence=Displayed; Name=2; IsoId=Q15049-2; Sequence=VSP_055494; Note=No experimental confirmation available.; 
# BioGrid	116816	15
# CCDS	CCDS14083	-. [Q15049-1]
# ChiTaRS	MLC1	human
# DISEASE	MLC1_HUMAN	Leukoencephalopathy, megalencephalic, with subcortical cysts, 1 (MLC1) [MIM 604004]  A syndrome of cerebral leukoencephalopathy and megalencephaly characterized by ataxia, spasticity, seizures, delay in motor development and mild mental retardation. The brain appears swollen on magnetic resonance imaging, with diffuse white-matter abnormalities and the invariable presence of subcortical cysts in frontal and temporal lobes. {ECO 0000269|PubMed 11254442, ECO 0000269|PubMed 11935341, ECO 0000269|PubMed 12189496, ECO 0000269|PubMed 16652334}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000311597	ENSP00000310375; ENSG00000100427. [Q15049-1]
# Ensembl	ENST00000395876	ENSP00000379216; ENSG00000100427. [Q15049-1]
# ExpressionAtlas	Q15049	baseline and differential
# FUNCTION	MLC1_HUMAN	Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx. {ECO 0000269|PubMed 22328087}. 
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005764	lysosome; ISS:UniProtKB.
# GO_component	GO:0005768	endosome; IDA:UniProtKB.
# GO_component	GO:0005769	early endosome; ISS:UniProtKB.
# GO_component	GO:0005783	endoplasmic reticulum; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005901	caveola; ISS:UniProtKB.
# GO_component	GO:0005911	cell-cell junction; IEA:Ensembl.
# GO_component	GO:0016021	integral component of membrane; IDA:UniProtKB.
# GO_component	GO:0016323	basolateral plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IEA:Ensembl.
# GO_component	GO:0031410	cytoplasmic vesicle; IDA:UniProtKB.
# GO_component	GO:0045121	membrane raft; ISS:UniProtKB.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IDA:UniProtKB.
# GO_component	GO:0055037	recycling endosome; ISS:UniProtKB.
# GO_function	GO:0005215	transporter activity; NAS:UniProtKB.
# GO_function	GO:0008565	protein transporter activity; ISS:UniProtKB.
# GO_function	GO:0032403	protein complex binding; IDA:UniProtKB.
# GO_process	GO:0006810	transport; NAS:UniProtKB.
# GO_process	GO:0006811	ion transport; IEA:UniProtKB-KW.
# GO_process	GO:0016192	vesicle-mediated transport; ISS:UniProtKB.
# GO_process	GO:0032388	positive regulation of intracellular transport; IDA:UniProtKB.
# GO_process	GO:0047484	regulation of response to osmotic stress; IMP:UniProtKB.
# GO_process	GO:0051259	protein oligomerization; IDA:UniProtKB.
# GO_process	GO:0071397	cellular response to cholesterol; ISS:UniProtKB.
# GO_process	GO:0072584	caveolin-mediated endocytosis; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005764	lysosome
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# Genevisible	Q15049	HS
# HGNC	HGNC:17082	MLC1
# IntAct	Q15049	5
# InterPro	IPR033280	Membrane_MLC1
# KEGG_Disease	H00875	[Nervous system disease] Megalencephalic leukoencephalopathy with subcortical cysts (MLC)
# MIM	604004	phenotype
# MIM	605908	gene
# Organism	MLC1_HUMAN	Homo sapiens (Human)
# Orphanet	2478	Megalencephalic leukoencephalopathy with subcortical cysts
# PANTHER	PTHR17597	PTHR17597
# ProDom	PD492528	PD492528
# Proteomes	UP000005640	Chromosome 22
# RecName	MLC1_HUMAN	Membrane protein MLC1
# RefSeq	NP_055981	NM_015166.3. [Q15049-1]
# RefSeq	NP_631941	NM_139202.2. [Q15049-1]
# RefSeq	XP_016884160	XM_017028671.1. [Q15049-1]
# SEQUENCE CAUTION	Sequence=BAA04947.3; Type=Erroneous initiation; Evidence={ECO	0000305}; 
# SUBCELLULAR LOCATION	MLC1_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. Cell membrane {ECO 0000269|PubMed 22328087}. Cytoplasm, perinuclear region {ECO 0000269|PubMed 22328087}. Endoplasmic reticulum {ECO 0000269|PubMed 22328087}. 
# SUBUNIT	Interacts with ATP1B1. Part of a complex containing ATP1B1, TRPV4, AQP4 and HEPACAM. {ECO:0000269|PubMed	22328087}. 
# TCDB	9.B.129.1	the membrane protein mlc1 family
# TISSUE SPECIFICITY	Expressed in the brain, with highest levels found in the amygdala, nucleus caudatus, thalamus and hippocampus. {ECO:0000269|PubMed	11326298}. 
# UCSC	uc003bjg	human. [Q15049-1]
# WEB RESOURCE	MLC1_HUMAN	Name=Mendelian genes megalencephalic leukoencephalopathy with subcortical cysts 1 (MLC1); Note=Leiden Open Variation Database (LOVD); URL="http //www.lovd.nl/MLC1";
# eggNOG	ENOG410IGRJ	Eukaryota
# eggNOG	ENOG410YAP9	LUCA
BLAST	swissprot:MLC1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MLC1_HUMAN
BioCyc	ZFISH:ENSG00000100427-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000100427-MONOMER
COXPRESdb	23209	http://coxpresdb.jp/data/gene/23209.shtml
CleanEx	HS_MLC1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_MLC1
DOI	10.1002/humu.20332	http://dx.doi.org/10.1002/humu.20332
DOI	10.1007/s00439-002-0682-x	http://dx.doi.org/10.1007/s00439-002-0682-x
DOI	10.1007/s00439-002-0770-y	http://dx.doi.org/10.1007/s00439-002-0770-y
DOI	10.1038/990031	http://dx.doi.org/10.1038/990031
DOI	10.1038/nbt810	http://dx.doi.org/10.1038/nbt810
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.mp.4000869	http://dx.doi.org/10.1038/sj.mp.4000869
DOI	10.1086/319519	http://dx.doi.org/10.1086/319519
DOI	10.1093/dnares/1.1.27	http://dx.doi.org/10.1093/dnares/1.1.27
DOI	10.1093/dnares/9.3.99	http://dx.doi.org/10.1093/dnares/9.3.99
DOI	10.1093/hmg/dds032	http://dx.doi.org/10.1093/hmg/dds032
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/gb-2004-5-10-r84	http://dx.doi.org/10.1186/gb-2004-5-10-r84
EMBL	AF319633	http://www.ebi.ac.uk/ena/data/view/AF319633
EMBL	AK124264	http://www.ebi.ac.uk/ena/data/view/AK124264
EMBL	AK299841	http://www.ebi.ac.uk/ena/data/view/AK299841
EMBL	AL022327	http://www.ebi.ac.uk/ena/data/view/AL022327
EMBL	BC028425	http://www.ebi.ac.uk/ena/data/view/BC028425
EMBL	CH471138	http://www.ebi.ac.uk/ena/data/view/CH471138
EMBL	CR456460	http://www.ebi.ac.uk/ena/data/view/CR456460
EMBL	D25217	http://www.ebi.ac.uk/ena/data/view/D25217
Ensembl	ENST00000311597	http://www.ensembl.org/id/ENST00000311597
Ensembl	ENST00000395876	http://www.ensembl.org/id/ENST00000395876
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GO_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GO_component	GO:0005769	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005769
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005901
GO_component	GO:0005911	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005911
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GO_component	GO:0045121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045121
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_component	GO:0055037	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055037
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0032403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032403
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GO_process	GO:0032388	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032388
GO_process	GO:0047484	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047484
GO_process	GO:0051259	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051259
GO_process	GO:0071397	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071397
GO_process	GO:0072584	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072584
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GeneCards	MLC1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=MLC1
GeneID	23209	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23209
GeneTree	ENSGT00390000015442	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000015442
HGNC	HGNC:17082	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17082
HOGENOM	HOG000065767	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000065767&db=HOGENOM6
HOVERGEN	HBG049239	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG049239&db=HOVERGEN
HPA	HPA003040	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA003040
HPA	HPA067533	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA067533
InParanoid	Q15049	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q15049
IntAct	Q15049	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q15049*
InterPro	IPR033280	http://www.ebi.ac.uk/interpro/entry/IPR033280
Jabion	23209	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=23209
KEGG_Disease	H00875	http://www.genome.jp/dbget-bin/www_bget?H00875
KEGG_Gene	hsa:23209	http://www.genome.jp/dbget-bin/www_bget?hsa:23209
MIM	604004	http://www.ncbi.nlm.nih.gov/omim/604004
MIM	605908	http://www.ncbi.nlm.nih.gov/omim/605908
MINT	MINT-8417695	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8417695
OMA	FKDYPPA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FKDYPPA
Orphanet	2478	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=2478
OrthoDB	EOG091G0AUD	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0AUD
PANTHER	PTHR17597	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17597
PSORT	swissprot:MLC1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MLC1_HUMAN
PSORT-B	swissprot:MLC1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MLC1_HUMAN
PSORT2	swissprot:MLC1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MLC1_HUMAN
PharmGKB	PA38199	http://www.pharmgkb.org/do/serve?objId=PA38199&objCls=Gene
Phobius	swissprot:MLC1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MLC1_HUMAN
PhylomeDB	Q15049	http://phylomedb.org/?seqid=Q15049
ProteinModelPortal	Q15049	http://www.proteinmodelportal.org/query/uniprot/Q15049
PubMed	10591208	http://www.ncbi.nlm.nih.gov/pubmed/10591208
PubMed	11254442	http://www.ncbi.nlm.nih.gov/pubmed/11254442
PubMed	11326298	http://www.ncbi.nlm.nih.gov/pubmed/11326298
PubMed	11935341	http://www.ncbi.nlm.nih.gov/pubmed/11935341
PubMed	12168954	http://www.ncbi.nlm.nih.gov/pubmed/12168954
PubMed	12189496	http://www.ncbi.nlm.nih.gov/pubmed/12189496
PubMed	12665801	http://www.ncbi.nlm.nih.gov/pubmed/12665801
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15461802	http://www.ncbi.nlm.nih.gov/pubmed/15461802
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16652334	http://www.ncbi.nlm.nih.gov/pubmed/16652334
PubMed	22328087	http://www.ncbi.nlm.nih.gov/pubmed/22328087
PubMed	7584026	http://www.ncbi.nlm.nih.gov/pubmed/7584026
RefSeq	NP_055981	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055981
RefSeq	NP_631941	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_631941
RefSeq	XP_016884160	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016884160
STRING	9606.ENSP00000310375	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000310375&targetmode=cogs
TCDB	9.B.129.1	http://www.tcdb.org/search/result.php?tc=9.B.129.1
UCSC	uc003bjg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003bjg&org=rat
UniGene	Hs.517729	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.517729
UniProtKB	MLC1_HUMAN	http://www.uniprot.org/uniprot/MLC1_HUMAN
UniProtKB-AC	Q15049	http://www.uniprot.org/uniprot/Q15049
charge	swissprot:MLC1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MLC1_HUMAN
eggNOG	ENOG410IGRJ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IGRJ
eggNOG	ENOG410YAP9	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YAP9
epestfind	swissprot:MLC1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MLC1_HUMAN
garnier	swissprot:MLC1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MLC1_HUMAN
helixturnhelix	swissprot:MLC1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MLC1_HUMAN
hmoment	swissprot:MLC1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MLC1_HUMAN
iep	swissprot:MLC1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MLC1_HUMAN
inforesidue	swissprot:MLC1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MLC1_HUMAN
neXtProt	NX_Q15049	http://www.nextprot.org/db/entry/NX_Q15049
octanol	swissprot:MLC1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MLC1_HUMAN
pepcoil	swissprot:MLC1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MLC1_HUMAN
pepdigest	swissprot:MLC1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MLC1_HUMAN
pepinfo	swissprot:MLC1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MLC1_HUMAN
pepnet	swissprot:MLC1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MLC1_HUMAN
pepstats	swissprot:MLC1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MLC1_HUMAN
pepwheel	swissprot:MLC1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MLC1_HUMAN
pepwindow	swissprot:MLC1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MLC1_HUMAN
sigcleave	swissprot:MLC1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MLC1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	FLOWR_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9UGQ2-1; Sequence=Displayed; Name=2; IsoId=Q9UGQ2-2; Sequence=VSP_012997; Name=3; IsoId=Q9UGQ2-3; Sequence=VSP_012997, VSP_042522; Note=No experimental confirmation available.; Name=4; IsoId=Q9UGQ2-4; Sequence=VSP_042522; Note=No experimental confirmation available.; 
# AltName	FLOWR_HUMAN	Calcium channel flower domain-containing protein 1
# BioGrid	116275	2
# CCDS	CCDS48051	-. [Q9UGQ2-2]
# CCDS	CCDS56591	-. [Q9UGQ2-4]
# CCDS	CCDS56592	-. [Q9UGQ2-3]
# CCDS	CCDS6974	-. [Q9UGQ2-1]
# Ensembl	ENST00000291722	ENSP00000291722; ENSG00000160325. [Q9UGQ2-2]
# Ensembl	ENST00000316948	ENSP00000317121; ENSG00000160325. [Q9UGQ2-1]
# Ensembl	ENST00000540581	ENSP00000440832; ENSG00000160325. [Q9UGQ2-4]
# Ensembl	ENST00000542192	ENSP00000444328; ENSG00000160325. [Q9UGQ2-3]
# Ensembl	ENST00000625979	ENSP00000486098; ENSG00000280479. [Q9UGQ2-2]
# Ensembl	ENST00000627083	ENSP00000486812; ENSG00000280479. [Q9UGQ2-3]
# Ensembl	ENST00000629431	ENSP00000486696; ENSG00000280479. [Q9UGQ2-1]
# Ensembl	ENST00000630997	ENSP00000485922; ENSG00000280479. [Q9UGQ2-4]
# ExpressionAtlas	Q9UGQ2	baseline and differential
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005262	calcium channel activity; TAS:Reactome.
# GO_process	GO:0016192	vesicle-mediated transport; IBA:GO_Central.
# GO_process	GO:0051899	membrane depolarization; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# Genevisible	Q9UGQ2	HS
# HGNC	HGNC:1365	CACFD1
# INTERACTION	FLOWR_HUMAN	Q96B96 TMEM159; NbExp=4; IntAct=EBI-8652492, EBI-7055862; 
# InterPro	IPR019365	TVP18/Ca-channel_flower
# MIM	613104	gene
# Organism	FLOWR_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR13314	PTHR13314
# Pfam	PF10233	Cg6151-P
# Proteomes	UP000005640	Chromosome 9
# Reactome	R-HSA-112308	Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
# RecName	FLOWR_HUMAN	Calcium channel flower homolog
# RefSeq	NP_001129247	NM_001135775.2. [Q9UGQ2-2]
# RefSeq	NP_001229298	NM_001242369.1. [Q9UGQ2-4]
# RefSeq	NP_001229299	NM_001242370.1. [Q9UGQ2-3]
# RefSeq	NP_060056	NM_017586.3. [Q9UGQ2-1]
# SIMILARITY	Belongs to the calcium channel flower family. {ECO	0000305}.
# SMART	SM01077	Cg6151-P
# SUBCELLULAR LOCATION	FLOWR_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	1.A.55.1	the synaptic vesicle-associated ca(2+) channel, flower (flower) family
# UCSC	uc004cec	human. [Q9UGQ2-1]
BLAST	swissprot:FLOWR_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:FLOWR_HUMAN
COXPRESdb	11094	http://coxpresdb.jp/data/gene/11094.shtml
CleanEx	HS_C9orf7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_C9orf7
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/dnares/12.2.117	http://dx.doi.org/10.1093/dnares/12.2.117
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AJ011373	http://www.ebi.ac.uk/ena/data/view/AJ011373
EMBL	AK074852	http://www.ebi.ac.uk/ena/data/view/AK074852
EMBL	AK075416	http://www.ebi.ac.uk/ena/data/view/AK075416
EMBL	AK075548	http://www.ebi.ac.uk/ena/data/view/AK075548
EMBL	AK296343	http://www.ebi.ac.uk/ena/data/view/AK296343
EMBL	AK298820	http://www.ebi.ac.uk/ena/data/view/AK298820
EMBL	AL593848	http://www.ebi.ac.uk/ena/data/view/AL593848
EMBL	AY358452	http://www.ebi.ac.uk/ena/data/view/AY358452
EMBL	BC030558	http://www.ebi.ac.uk/ena/data/view/BC030558
Ensembl	ENST00000291722	http://www.ensembl.org/id/ENST00000291722
Ensembl	ENST00000316948	http://www.ensembl.org/id/ENST00000316948
Ensembl	ENST00000540581	http://www.ensembl.org/id/ENST00000540581
Ensembl	ENST00000542192	http://www.ensembl.org/id/ENST00000542192
Ensembl	ENST00000625979	http://www.ensembl.org/id/ENST00000625979
Ensembl	ENST00000627083	http://www.ensembl.org/id/ENST00000627083
Ensembl	ENST00000629431	http://www.ensembl.org/id/ENST00000629431
Ensembl	ENST00000630997	http://www.ensembl.org/id/ENST00000630997
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GO_process	GO:0051899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051899
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GeneCards	CACFD1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CACFD1
GeneID	11094	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11094
GeneTree	ENSGT00390000000529	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000000529
HGNC	HGNC:1365	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1365
HOGENOM	HOG000231809	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231809&db=HOGENOM6
HOVERGEN	HBG050956	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050956&db=HOVERGEN
HPA	HPA015280	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA015280
InParanoid	Q9UGQ2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UGQ2
IntAct	Q9UGQ2	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9UGQ2*
InterPro	IPR019365	http://www.ebi.ac.uk/interpro/entry/IPR019365
Jabion	11094	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=11094
KEGG_Gene	hsa:11094	http://www.genome.jp/dbget-bin/www_bget?hsa:11094
MIM	613104	http://www.ncbi.nlm.nih.gov/omim/613104
OMA	CGMAVIP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CGMAVIP
OrthoDB	EOG091G0TAC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0TAC
PANTHER	PTHR13314	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13314
PSORT	swissprot:FLOWR_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:FLOWR_HUMAN
PSORT-B	swissprot:FLOWR_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:FLOWR_HUMAN
PSORT2	swissprot:FLOWR_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:FLOWR_HUMAN
Pfam	PF10233	http://pfam.xfam.org/family/PF10233
PharmGKB	PA25982	http://www.pharmgkb.org/do/serve?objId=PA25982&objCls=Gene
Phobius	swissprot:FLOWR_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:FLOWR_HUMAN
PhylomeDB	Q9UGQ2	http://phylomedb.org/?seqid=Q9UGQ2
ProteinModelPortal	Q9UGQ2	http://www.proteinmodelportal.org/query/uniprot/Q9UGQ2
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16303743	http://www.ncbi.nlm.nih.gov/pubmed/16303743
Reactome	R-HSA-112308	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112308
RefSeq	NP_001129247	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001129247
RefSeq	NP_001229298	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001229298
RefSeq	NP_001229299	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001229299
RefSeq	NP_060056	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060056
SMART	SM01077	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01077
TCDB	1.A.55.1	http://www.tcdb.org/search/result.php?tc=1.A.55.1
UCSC	uc004cec	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004cec&org=rat
UniGene	Hs.62003	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.62003
UniProtKB	FLOWR_HUMAN	http://www.uniprot.org/uniprot/FLOWR_HUMAN
UniProtKB-AC	Q9UGQ2	http://www.uniprot.org/uniprot/Q9UGQ2
charge	swissprot:FLOWR_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:FLOWR_HUMAN
epestfind	swissprot:FLOWR_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:FLOWR_HUMAN
garnier	swissprot:FLOWR_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:FLOWR_HUMAN
helixturnhelix	swissprot:FLOWR_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLOWR_HUMAN
hmoment	swissprot:FLOWR_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:FLOWR_HUMAN
iep	swissprot:FLOWR_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:FLOWR_HUMAN
inforesidue	swissprot:FLOWR_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:FLOWR_HUMAN
neXtProt	NX_Q9UGQ2	http://www.nextprot.org/db/entry/NX_Q9UGQ2
octanol	swissprot:FLOWR_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:FLOWR_HUMAN
pepcoil	swissprot:FLOWR_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:FLOWR_HUMAN
pepdigest	swissprot:FLOWR_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:FLOWR_HUMAN
pepinfo	swissprot:FLOWR_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:FLOWR_HUMAN
pepnet	swissprot:FLOWR_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:FLOWR_HUMAN
pepstats	swissprot:FLOWR_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:FLOWR_HUMAN
pepwheel	swissprot:FLOWR_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:FLOWR_HUMAN
pepwindow	swissprot:FLOWR_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:FLOWR_HUMAN
sigcleave	swissprot:FLOWR_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:FLOWR_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ACHA4_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P43681-1; Sequence=Displayed; Name=2; IsoId=P43681-2; Sequence=VSP_054275, VSP_054276; Note=No experimental confirmation available.; 
# BioGrid	107559	4
# CCDS	CCDS13517	-. [P43681-1]
# ChiTaRS	CHRNA4	human
# DISEASE	ACHA4_HUMAN	Epilepsy, nocturnal frontal lobe, 1 (ENFL1) [MIM 600513]  An autosomal dominant focal epilepsy characterized by nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements. {ECO 0000269|PubMed 10563623, ECO 0000269|PubMed 14623738, ECO 0000269|PubMed 7550350}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00184	Nicotine
# DrugBank	DB00237	Butabarbital
# DrugBank	DB00241	Butalbital
# DrugBank	DB00306	Talbutal
# DrugBank	DB00312	Pentobarbital
# DrugBank	DB00418	Secobarbital
# DrugBank	DB00514	Dextromethorphan
# DrugBank	DB00599	Thiopental
# DrugBank	DB00674	Galantamine
# DrugBank	DB00794	Primidone
# DrugBank	DB00849	Methylphenobarbital
# DrugBank	DB00898	Ethanol
# DrugBank	DB01174	Phenobarbital
# DrugBank	DB01273	Varenicline
# DrugBank	DB01351	Amobarbital
# DrugBank	DB01352	Aprobarbital
# DrugBank	DB01353	Butethal
# DrugBank	DB01354	Heptabarbital
# DrugBank	DB01355	Hexobarbital
# DrugBank	DB09028	Cytisine
# Ensembl	ENST00000370263	ENSP00000359285; ENSG00000101204. [P43681-1]
# Ensembl	ENST00000615287	ENSP00000483388; ENSG00000101204. [P43681-2]
# ExpressionAtlas	P43681	baseline and differential
# FUNCTION	ACHA4_HUMAN	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions. {ECO 0000269|PubMed 22361591}. 
# GO_component	GO:0005886	plasma membrane; ISS:UniProtKB.
# GO_component	GO:0005892	acetylcholine-gated channel complex; IDA:UniProtKB.
# GO_component	GO:0009897	external side of plasma membrane; ISS:UniProtKB.
# GO_component	GO:0016020	membrane; ISS:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030425	dendrite; ISS:UniProtKB.
# GO_component	GO:0043025	neuronal cell body; ISS:UniProtKB.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0004889	acetylcholine-activated cation-selective channel activity; IDA:UniProtKB.
# GO_function	GO:0015276	ligand-gated ion channel activity; TAS:DFLAT.
# GO_function	GO:0015464	acetylcholine receptor activity; IDA:UniProtKB.
# GO_function	GO:0042166	acetylcholine binding; IC:UniProtKB.
# GO_process	GO:0001508	action potential; ISS:UniProtKB.
# GO_process	GO:0001666	response to hypoxia; IDA:UniProtKB.
# GO_process	GO:0006281	DNA repair; IMP:UniProtKB.
# GO_process	GO:0006811	ion transport; NAS:UniProtKB.
# GO_process	GO:0006816	calcium ion transport; ISS:UniProtKB.
# GO_process	GO:0006979	response to oxidative stress; IMP:UniProtKB.
# GO_process	GO:0007165	signal transduction; IDA:UniProtKB.
# GO_process	GO:0007268	chemical synaptic transmission; NAS:UniProtKB.
# GO_process	GO:0007271	synaptic transmission, cholinergic; ISS:UniProtKB.
# GO_process	GO:0007274	neuromuscular synaptic transmission; IBA:GO_Central.
# GO_process	GO:0007585	respiratory gaseous exchange; IEA:Ensembl.
# GO_process	GO:0007626	locomotory behavior; IEA:Ensembl.
# GO_process	GO:0014059	regulation of dopamine secretion; ISS:UniProtKB.
# GO_process	GO:0019233	sensory perception of pain; ISS:UniProtKB.
# GO_process	GO:0035094	response to nicotine; IDA:UniProtKB.
# GO_process	GO:0035095	behavioral response to nicotine; IMP:UniProtKB.
# GO_process	GO:0035640	exploration behavior; IEA:Ensembl.
# GO_process	GO:0042113	B cell activation; ISS:UniProtKB.
# GO_process	GO:0042391	regulation of membrane potential; ISS:UniProtKB.
# GO_process	GO:0050877	neurological system process; IMP:UniProtKB.
# GO_process	GO:0050890	cognition; IMP:UniProtKB.
# GO_process	GO:0051899	membrane depolarization; ISS:UniProtKB.
# GO_process	GO:0060080	inhibitory postsynaptic potential; ISS:UniProtKB.
# GO_process	GO:0095500	acetylcholine receptor signaling pathway; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006259	DNA metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# Gene3D	1.20.120.370	-; 2.
# Gene3D	2.70.170.10	-; 1.
# Genevisible	P43681	HS
# HGNC	HGNC:1958	CHRNA4
# IntAct	P43681	2
# InterPro	IPR002394	Nicotinic_acetylcholine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# InterPro	IPR027361	Acetylcholine_rcpt_TM
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00807	[Nervous system disease] Nocturnal frontal lobe epilepsy (NFLE)
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04725	Cholinergic synapse
# KEGG_Pathway	ko05033	Nicotine addiction
# MIM	118504	gene
# MIM	600513	phenotype
# Organism	ACHA4_HUMAN	Homo sapiens (Human)
# Orphanet	98784	Autosomal dominant nocturnal frontal lobe epilepsy
# PANTHER	PTHR18945	PTHR18945; 3
# PDB	2GVT	Model; -; A/C=38-241
# PDB	2LLY	NMR; -; A=240-339, A=598-626
# PDB	5KXI	X-ray; 3.94 A; A/D=27-364, A/D=586-627
# PIR	JC4021	JC4021
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00254	NICOTINICR
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 20
# Reactome	R-HSA-629587	Highly sodium permeable acetylcholine nicotinic receptors
# Reactome	R-HSA-629594	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
# Reactome	R-HSA-629597	Highly calcium permeable nicotinic acetylcholine receptors
# RecName	ACHA4_HUMAN	Neuronal acetylcholine receptor subunit alpha-4
# RefSeq	NP_000735	NM_000744.6. [P43681-1]
# RefSeq	NP_001243502	NM_001256573.1
# RefSeq	XP_011526826	XM_011528524.1. [P43681-2]
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 4/CHRNA4 sub-subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	ACHA4_HUMAN	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell membrane {ECO 0000250}; Lipid-anchor {ECO 0000250}. 
# SUBUNIT	ACHA4_HUMAN	Neuronal AChR is composed of two different types of subunits  alpha and beta. Alpha-4 subunit can be combined to beta- 2 or beta-4 to give rise to functional receptors, complexes with beta-2 may be heteropentamers. Interacts with RIC3; which is required for proper folding and assembly. {ECO 0000269|PubMed 16120769, ECO 0000269|PubMed 22361591}. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112; 2
# TCDB	1.A.9.1	the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family
# TIGRFAMs	TIGR00860	LIC
# UCSC	uc002yes	human. [P43681-1]
# WEB RESOURCE	ACHA4_HUMAN	Name=NIEHS-SNPs; URL="http //egp.gs.washington.edu/data/chrna4/";
# eggNOG	ENOG410XQGR	LUCA
# eggNOG	KOG3645	Eukaryota
BLAST	swissprot:ACHA4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ACHA4_HUMAN
BioCyc	ZFISH:ENSG00000101204-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000101204-MONOMER
COXPRESdb	1137	http://coxpresdb.jp/data/gene/1137.shtml
CleanEx	HS_CHRNA4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CHRNA4
DOI	10.1001/archneur.60.11.1625	http://dx.doi.org/10.1001/archneur.60.11.1625
DOI	10.1006/geno.1996.0119	http://dx.doi.org/10.1006/geno.1996.0119
DOI	10.1007/BF02736842	http://dx.doi.org/10.1007/BF02736842
DOI	10.1016/0378-1119(94)00914-E	http://dx.doi.org/10.1016/0378-1119(94)00914-E
DOI	10.1016/S0014-5793(96)01383-X	http://dx.doi.org/10.1016/S0014-5793(96)01383-X
DOI	10.1016/j.bbamem.2012.02.008	http://dx.doi.org/10.1016/j.bbamem.2012.02.008
DOI	10.1038/414865a	http://dx.doi.org/10.1038/414865a
DOI	10.1038/ng1095-201	http://dx.doi.org/10.1038/ng1095-201
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1124/mol.105.017459	http://dx.doi.org/10.1124/mol.105.017459
DOI	10.1212/WNL.53.8.1749	http://dx.doi.org/10.1212/WNL.53.8.1749
DrugBank	DB00184	http://www.drugbank.ca/drugs/DB00184
DrugBank	DB00237	http://www.drugbank.ca/drugs/DB00237
DrugBank	DB00241	http://www.drugbank.ca/drugs/DB00241
DrugBank	DB00306	http://www.drugbank.ca/drugs/DB00306
DrugBank	DB00312	http://www.drugbank.ca/drugs/DB00312
DrugBank	DB00418	http://www.drugbank.ca/drugs/DB00418
DrugBank	DB00514	http://www.drugbank.ca/drugs/DB00514
DrugBank	DB00599	http://www.drugbank.ca/drugs/DB00599
DrugBank	DB00674	http://www.drugbank.ca/drugs/DB00674
DrugBank	DB00794	http://www.drugbank.ca/drugs/DB00794
DrugBank	DB00849	http://www.drugbank.ca/drugs/DB00849
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01174	http://www.drugbank.ca/drugs/DB01174
DrugBank	DB01273	http://www.drugbank.ca/drugs/DB01273
DrugBank	DB01351	http://www.drugbank.ca/drugs/DB01351
DrugBank	DB01352	http://www.drugbank.ca/drugs/DB01352
DrugBank	DB01353	http://www.drugbank.ca/drugs/DB01353
DrugBank	DB01354	http://www.drugbank.ca/drugs/DB01354
DrugBank	DB01355	http://www.drugbank.ca/drugs/DB01355
DrugBank	DB09028	http://www.drugbank.ca/drugs/DB09028
EMBL	AL121827	http://www.ebi.ac.uk/ena/data/view/AL121827
EMBL	BC096290	http://www.ebi.ac.uk/ena/data/view/BC096290
EMBL	BC096291	http://www.ebi.ac.uk/ena/data/view/BC096291
EMBL	DQ093071	http://www.ebi.ac.uk/ena/data/view/DQ093071
EMBL	L35901	http://www.ebi.ac.uk/ena/data/view/L35901
EMBL	U62433	http://www.ebi.ac.uk/ena/data/view/U62433
EMBL	X87629	http://www.ebi.ac.uk/ena/data/view/X87629
EMBL	X89741	http://www.ebi.ac.uk/ena/data/view/X89741
EMBL	X89742	http://www.ebi.ac.uk/ena/data/view/X89742
EMBL	X89743	http://www.ebi.ac.uk/ena/data/view/X89743
EMBL	X89744	http://www.ebi.ac.uk/ena/data/view/X89744
EMBL	X89745	http://www.ebi.ac.uk/ena/data/view/X89745
EMBL	X89746	http://www.ebi.ac.uk/ena/data/view/X89746
EMBL	Y08421	http://www.ebi.ac.uk/ena/data/view/Y08421
Ensembl	ENST00000370263	http://www.ensembl.org/id/ENST00000370263
Ensembl	ENST00000615287	http://www.ensembl.org/id/ENST00000615287
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005892	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005892
GO_component	GO:0009897	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009897
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0004889	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004889
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_function	GO:0015464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015464
GO_function	GO:0042166	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042166
GO_process	GO:0001508	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001508
GO_process	GO:0001666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001666
GO_process	GO:0006281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0006979	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007271
GO_process	GO:0007274	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007274
GO_process	GO:0007585	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007585
GO_process	GO:0007626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007626
GO_process	GO:0014059	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014059
GO_process	GO:0019233	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019233
GO_process	GO:0035094	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035094
GO_process	GO:0035095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035095
GO_process	GO:0035640	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035640
GO_process	GO:0042113	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042113
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GO_process	GO:0050890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050890
GO_process	GO:0051899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051899
GO_process	GO:0060080	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060080
GO_process	GO:0095500	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0095500
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006259	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
Gene3D	1.20.120.370	http://www.cathdb.info/version/latest/superfamily/1.20.120.370
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	CHRNA4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CHRNA4
GeneID	1137	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1137
GeneTree	ENSGT00760000118930	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118930
HGNC	HGNC:1958	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1958
HOGENOM	HOG000006756	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006756&db=HOGENOM6
HOVERGEN	HBG003756	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003756&db=HOVERGEN
HPA	CAB034064	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB034064
InParanoid	P43681	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P43681
IntAct	P43681	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P43681*
InterPro	IPR002394	http://www.ebi.ac.uk/interpro/entry/IPR002394
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
InterPro	IPR027361	http://www.ebi.ac.uk/interpro/entry/IPR027361
Jabion	1137	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1137
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00807	http://www.genome.jp/dbget-bin/www_bget?H00807
KEGG_Gene	hsa:1137	http://www.genome.jp/dbget-bin/www_bget?hsa:1137
KEGG_Orthology	KO:K04806	http://www.genome.jp/dbget-bin/www_bget?KO:K04806
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04725	http://www.genome.jp/kegg-bin/show_pathway?ko04725
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
MIM	118504	http://www.ncbi.nlm.nih.gov/omim/118504
MIM	600513	http://www.ncbi.nlm.nih.gov/omim/600513
MINT	MINT-3015931	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3015931
OMA	HMSSPGE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HMSSPGE
Orphanet	98784	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98784
OrthoDB	EOG091G0R20	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0R20
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PDB	2GVT	http://www.ebi.ac.uk/pdbe-srv/view/entry/2GVT
PDB	2LLY	http://www.ebi.ac.uk/pdbe-srv/view/entry/2LLY
PDB	5KXI	http://www.ebi.ac.uk/pdbe-srv/view/entry/5KXI
PDBsum	2GVT	http://www.ebi.ac.uk/pdbsum/2GVT
PDBsum	2LLY	http://www.ebi.ac.uk/pdbsum/2LLY
PDBsum	5KXI	http://www.ebi.ac.uk/pdbsum/5KXI
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00254	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00254
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:ACHA4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ACHA4_HUMAN
PSORT-B	swissprot:ACHA4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ACHA4_HUMAN
PSORT2	swissprot:ACHA4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ACHA4_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA26490	http://www.pharmgkb.org/do/serve?objId=PA26490&objCls=Gene
Phobius	swissprot:ACHA4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ACHA4_HUMAN
PhylomeDB	P43681	http://phylomedb.org/?seqid=P43681
ProteinModelPortal	P43681	http://www.proteinmodelportal.org/query/uniprot/P43681
PubMed	10563623	http://www.ncbi.nlm.nih.gov/pubmed/10563623
PubMed	11780052	http://www.ncbi.nlm.nih.gov/pubmed/11780052
PubMed	14623738	http://www.ncbi.nlm.nih.gov/pubmed/14623738
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16120769	http://www.ncbi.nlm.nih.gov/pubmed/16120769
PubMed	22361591	http://www.ncbi.nlm.nih.gov/pubmed/22361591
PubMed	7550350	http://www.ncbi.nlm.nih.gov/pubmed/7550350
PubMed	7721089	http://www.ncbi.nlm.nih.gov/pubmed/7721089
PubMed	8833159	http://www.ncbi.nlm.nih.gov/pubmed/8833159
PubMed	8906617	http://www.ncbi.nlm.nih.gov/pubmed/8906617
PubMed	9009220	http://www.ncbi.nlm.nih.gov/pubmed/9009220
Reactome	R-HSA-629587	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-629587
Reactome	R-HSA-629594	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-629594
Reactome	R-HSA-629597	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-629597
RefSeq	NP_000735	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000735
RefSeq	NP_001243502	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243502
RefSeq	XP_011526826	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011526826
SMR	P43681	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P43681
STRING	9606.ENSP00000359285	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000359285&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TCDB	1.A.9.1	http://www.tcdb.org/search/result.php?tc=1.A.9.1
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc002yes	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002yes&org=rat
UniGene	Hs.10734	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.10734
UniProtKB	ACHA4_HUMAN	http://www.uniprot.org/uniprot/ACHA4_HUMAN
UniProtKB-AC	P43681	http://www.uniprot.org/uniprot/P43681
charge	swissprot:ACHA4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ACHA4_HUMAN
eggNOG	ENOG410XQGR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQGR
eggNOG	KOG3645	http://eggnogapi.embl.de/nog_data/html/tree/KOG3645
epestfind	swissprot:ACHA4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ACHA4_HUMAN
garnier	swissprot:ACHA4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ACHA4_HUMAN
helixturnhelix	swissprot:ACHA4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACHA4_HUMAN
hmoment	swissprot:ACHA4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ACHA4_HUMAN
iep	swissprot:ACHA4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ACHA4_HUMAN
inforesidue	swissprot:ACHA4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ACHA4_HUMAN
neXtProt	NX_P43681	http://www.nextprot.org/db/entry/NX_P43681
octanol	swissprot:ACHA4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ACHA4_HUMAN
pepcoil	swissprot:ACHA4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ACHA4_HUMAN
pepdigest	swissprot:ACHA4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ACHA4_HUMAN
pepinfo	swissprot:ACHA4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ACHA4_HUMAN
pepnet	swissprot:ACHA4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ACHA4_HUMAN
pepstats	swissprot:ACHA4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ACHA4_HUMAN
pepwheel	swissprot:ACHA4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ACHA4_HUMAN
pepwindow	swissprot:ACHA4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ACHA4_HUMAN
sigcleave	swissprot:ACHA4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ACHA4_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	117039	5
# ChiTaRS	SEC61G	human
# Ensembl	ENST00000352861	ENSP00000341538; ENSG00000132432
# Ensembl	ENST00000395535	ENSP00000378906; ENSG00000132432
# Ensembl	ENST00000415949	ENSP00000388337; ENSG00000132432
# Ensembl	ENST00000450622	ENSP00000409884; ENSG00000132432
# ExpressionAtlas	P60059	baseline and differential
# FUNCTION	SC61G_HUMAN	Necessary for protein translocation in the endoplasmic reticulum. {ECO 0000250}. 
# GO_component	GO:0005789	endoplasmic reticulum membrane; TAS:Reactome.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0016020	membrane; IDA:MGI.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0008565	protein transporter activity; ISS:UniProtKB.
# GO_function	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity; IEA:InterPro.
# GO_process	GO:0036498	IRE1-mediated unfolded protein response; TAS:Reactome.
# GO_process	GO:0045047	protein targeting to ER; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005829	cytosol
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006605	protein targeting
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# Gene3D	1.20.5.820	-; 1.
# Genevisible	P60059	HS
# HAMAP	MF_00422	SecE
# HGNC	HGNC:18277	SEC61G
# INTERACTION	SC61G_HUMAN	P11686 SFTPC; NbExp=3; IntAct=EBI-4402709, EBI-10197617; 
# IntAct	P60059	2
# InterPro	IPR001901	Translocase_SecE/Sec61-g
# InterPro	IPR008158	Translocase_Sec61-g
# InterPro	IPR022943	SecE
# InterPro	IPR023391	Prot_translocase_SecE_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko02044	 M00401  Sec61 complex
# KEGG_Brite	ko02044	 Secretion system
# KEGG_Pathway	ko03060	Protein export
# KEGG_Pathway	ko04141	Protein processing in endoplasmic reticulum
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko05110	Vibrio cholerae infection
# MIM	609215	gene
# Organism	SC61G_HUMAN	Homo sapiens (Human)
# PIR	S42412	S42412
# PROSITE	PS01067	SECE_SEC61G
# Pfam	PF00584	SecE
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-1236974	ER-Phagosome pathway
# Reactome	R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane
# Reactome	R-HSA-381038	XBP1(S) activates chaperone genes
# RecName	SC61G_HUMAN	Protein transport protein Sec61 subunit gamma
# RefSeq	NP_001012474	NM_001012456.1
# RefSeq	NP_055117	NM_014302.3
# SIMILARITY	Belongs to the SecE/SEC61-gamma family. {ECO	0000305}.
# SUBCELLULAR LOCATION	SC61G_HUMAN	Endoplasmic reticulum membrane {ECO 0000250}; Single-pass membrane protein {ECO 0000250}. 
# SUBUNIT	Heterotrimeric complex composed of SEC61-alpha, SEC61- beta and SEC61-gamma. {ECO	0000250}. 
# SUPFAM	SSF103456	SSF103456
# TCDB	3.A.5.9	the general secretory pathway (sec) family
# TIGRFAMs	TIGR00327	secE_euk_arch
# UCSC	uc003tqf	human
# eggNOG	ENOG4111WJ7	LUCA
# eggNOG	KOG3498	Eukaryota
BLAST	swissprot:SC61G_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SC61G_HUMAN
BioCyc	ZFISH:ENSG00000132432-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000132432-MONOMER
COG	COG2443	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2443
COXPRESdb	23480	http://coxpresdb.jp/data/gene/23480.shtml
CleanEx	HS_SEC61G	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SEC61G
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1074/mcp.M111.015131	http://dx.doi.org/10.1074/mcp.M111.015131
DOI	10.1101/gr.140200	http://dx.doi.org/10.1101/gr.140200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF054184	http://www.ebi.ac.uk/ena/data/view/AF054184
EMBL	AK311845	http://www.ebi.ac.uk/ena/data/view/AK311845
EMBL	BC009480	http://www.ebi.ac.uk/ena/data/view/BC009480
EMBL	BC051840	http://www.ebi.ac.uk/ena/data/view/BC051840
EMBL	CH471201	http://www.ebi.ac.uk/ena/data/view/CH471201
EMBL	CR456979	http://www.ebi.ac.uk/ena/data/view/CR456979
Ensembl	ENST00000352861	http://www.ensembl.org/id/ENST00000352861
Ensembl	ENST00000395535	http://www.ensembl.org/id/ENST00000395535
Ensembl	ENST00000415949	http://www.ensembl.org/id/ENST00000415949
Ensembl	ENST00000450622	http://www.ensembl.org/id/ENST00000450622
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0015450	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015450
GO_process	GO:0036498	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036498
GO_process	GO:0045047	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045047
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
Gene3D	1.20.5.820	http://www.cathdb.info/version/latest/superfamily/1.20.5.820
GeneCards	SEC61G	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SEC61G
GeneID	23480	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23480
GeneTree	ENSGT00390000001319	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000001319
HAMAP	MF_00422	http://hamap.expasy.org/unirule/MF_00422
HGNC	HGNC:18277	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18277
HOGENOM	HOG000194479	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000194479&db=HOGENOM6
HOVERGEN	HBG058067	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG058067&db=HOVERGEN
HPA	HPA053196	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA053196
InParanoid	P60059	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P60059
IntAct	P60059	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P60059*
InterPro	IPR001901	http://www.ebi.ac.uk/interpro/entry/IPR001901
InterPro	IPR008158	http://www.ebi.ac.uk/interpro/entry/IPR008158
InterPro	IPR022943	http://www.ebi.ac.uk/interpro/entry/IPR022943
InterPro	IPR023391	http://www.ebi.ac.uk/interpro/entry/IPR023391
Jabion	23480	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=23480
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko02044	http://www.genome.jp/dbget-bin/www_bget?ko02044
KEGG_Brite	ko02044	http://www.genome.jp/dbget-bin/www_bget?ko02044
KEGG_Gene	hsa:23480	http://www.genome.jp/dbget-bin/www_bget?hsa:23480
KEGG_Orthology	KO:K07342	http://www.genome.jp/dbget-bin/www_bget?KO:K07342
KEGG_Pathway	ko03060	http://www.genome.jp/kegg-bin/show_pathway?ko03060
KEGG_Pathway	ko04141	http://www.genome.jp/kegg-bin/show_pathway?ko04141
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko05110	http://www.genome.jp/kegg-bin/show_pathway?ko05110
MIM	609215	http://www.ncbi.nlm.nih.gov/omim/609215
MINT	MINT-3021864	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3021864
OMA	HIPLNHA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HIPLNHA
OrthoDB	EOG091G19JS	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G19JS
PROSITE	PS01067	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01067
PSORT	swissprot:SC61G_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SC61G_HUMAN
PSORT-B	swissprot:SC61G_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SC61G_HUMAN
PSORT2	swissprot:SC61G_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SC61G_HUMAN
Pfam	PF00584	http://pfam.xfam.org/family/PF00584
PharmGKB	PA134939045	http://www.pharmgkb.org/do/serve?objId=PA134939045&objCls=Gene
Phobius	swissprot:SC61G_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SC61G_HUMAN
PhylomeDB	P60059	http://phylomedb.org/?seqid=P60059
ProteinModelPortal	P60059	http://www.proteinmodelportal.org/query/uniprot/P60059
PubMed	11042152	http://www.ncbi.nlm.nih.gov/pubmed/11042152
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	22223895	http://www.ncbi.nlm.nih.gov/pubmed/22223895
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-1236974	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1236974
Reactome	R-HSA-1799339	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1799339
Reactome	R-HSA-381038	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-381038
RefSeq	NP_001012474	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001012474
RefSeq	NP_055117	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055117
SMR	P60059	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P60059
STRING	9606.ENSP00000341538	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000341538&targetmode=cogs
STRING	COG2443	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2443&targetmode=cogs
SUPFAM	SSF103456	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103456
TCDB	3.A.5.9	http://www.tcdb.org/search/result.php?tc=3.A.5.9
TIGRFAMs	TIGR00327	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00327
UCSC	uc003tqf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003tqf&org=rat
UniGene	Hs.488282	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.488282
UniProtKB	SC61G_HUMAN	http://www.uniprot.org/uniprot/SC61G_HUMAN
UniProtKB-AC	P60059	http://www.uniprot.org/uniprot/P60059
charge	swissprot:SC61G_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SC61G_HUMAN
eggNOG	ENOG4111WJ7	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111WJ7
eggNOG	KOG3498	http://eggnogapi.embl.de/nog_data/html/tree/KOG3498
epestfind	swissprot:SC61G_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SC61G_HUMAN
garnier	swissprot:SC61G_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SC61G_HUMAN
helixturnhelix	swissprot:SC61G_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SC61G_HUMAN
hmoment	swissprot:SC61G_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SC61G_HUMAN
iep	swissprot:SC61G_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SC61G_HUMAN
inforesidue	swissprot:SC61G_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SC61G_HUMAN
neXtProt	NX_P60059	http://www.nextprot.org/db/entry/NX_P60059
octanol	swissprot:SC61G_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SC61G_HUMAN
pepcoil	swissprot:SC61G_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SC61G_HUMAN
pepdigest	swissprot:SC61G_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SC61G_HUMAN
pepinfo	swissprot:SC61G_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SC61G_HUMAN
pepnet	swissprot:SC61G_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SC61G_HUMAN
pepstats	swissprot:SC61G_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SC61G_HUMAN
pepwheel	swissprot:SC61G_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SC61G_HUMAN
pepwindow	swissprot:SC61G_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SC61G_HUMAN
sigcleave	swissprot:SC61G_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SC61G_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNC3_HUMAN	KSHIIID
# AltName	KCNC3_HUMAN	Voltage-gated potassium channel subunit Kv3.3
# ChiTaRS	KCNC3	human
# DISEASE	KCNC3_HUMAN	Spinocerebellar ataxia 13 (SCA13) [MIM 605259]  Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA13 is an autosomal dominant cerebellar ataxia (ADCA) characterized by slow progression and variable age at onset, ranging from childhood to late adulthood. Mental retardation can be present in some patients. {ECO 0000269|PubMed 16501573, ECO 0000269|PubMed 19953606, ECO 0000269|PubMed 21479265, ECO 0000269|PubMed 23734863, ECO 0000269|PubMed 25152487, ECO 0000269|PubMed 25756792}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	KCNC3_HUMAN	The C-terminal cytoplasmic tail contributes to the regulation of channel inactivation and to the interaction with HAX1 and the Arp2/3 complex. {ECO 0000269|PubMed 26997484}. 
# DOMAIN	KCNC3_HUMAN	The cytoplasmic N-terminus mediates N-type inactivation. {ECO 0000269|PubMed 26997484}. 
# DOMAIN	KCNC3_HUMAN	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. {ECO 0000305}. 
# DrugBank	DB06637	Dalfampridine
# Ensembl	ENST00000477616	ENSP00000434241; ENSG00000131398
# ExpressionAtlas	Q14003	baseline and differential
# FUNCTION	KCNC3_HUMAN	Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics (PubMed 10712820, PubMed 26997484, PubMed 22289912, PubMed 23734863, PubMed 16501573, PubMed 19953606, PubMed 21479265, PubMed 25756792). It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells. Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca(2+) channels and cellular Ca(2+) homeostasis (By similarity). Required for normal motor function (PubMed 23734863, PubMed 16501573, PubMed 19953606, PubMed 21479265, PubMed 25756792). Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex (PubMed 26997484). {ECO 0000250|UniProtKB Q63959, ECO 0000269|PubMed 10712820, ECO 0000269|PubMed 16501573, ECO 0000269|PubMed 19953606, ECO 0000269|PubMed 21479265, ECO 0000269|PubMed 22289912, ECO 0000269|PubMed 23734863, ECO 0000269|PubMed 25756792, ECO 0000269|PubMed 26997484}. 
# GO_component	GO:0005856	cytoskeleton; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005938	cell cortex; IEA:UniProtKB-SubCell.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IDA:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030424	axon; IEA:UniProtKB-SubCell.
# GO_component	GO:0030425	dendrite; IEA:UniProtKB-SubCell.
# GO_component	GO:0032591	dendritic spine membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0042734	presynaptic membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0043204	perikaryon; IEA:UniProtKB-SubCell.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IMP:UniProtKB.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; IBA:GO_Central.
# GO_process	GO:0051260	protein homooligomerization; IEA:InterPro.
# GO_process	GO:0051262	protein tetramerization; IDA:UniProtKB.
# GO_process	GO:0071805	potassium ion transmembrane transport; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005856	cytoskeleton
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.350	-; 1.
# Genevisible	Q14003	HS
# HGNC	HGNC:6235	KCNC3
# InterPro	IPR000210	BTB/POZ_dom
# InterPro	IPR003131	T1-type_BTB
# InterPro	IPR003968	K_chnl_volt-dep_Kv
# InterPro	IPR003974	K_chnl_volt-dep_Kv3
# InterPro	IPR005404	K_chnl_volt-dep_Kv3.3
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR011333	SKP1/BTB/POZ
# InterPro	IPR021105	K_chnl_volt-dep_Kv3_ID
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko04040	Ion channels
# KEGG_Disease	H00063	[Neurodegenerative disease] Spinocerebellar ataxia (SCA)
# MIM	176264	gene
# MIM	605259	phenotype
# Organism	KCNC3_HUMAN	Homo sapiens (Human)
# Orphanet	98768	Spinocerebellar ataxia type 13
# PANTHER	PTHR11537	PTHR11537; 3
# PIR	S19552	S19552
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01491	KVCHANNEL
# PRINTS	PR01498	SHAWCHANNEL
# PRINTS	PR01582	KV33CHANNEL
# PTM	KCNC3_HUMAN	N-glycosylated. {ECO 0000269|PubMed 25152487}. 
# Pfam	PF00520	Ion_trans
# Pfam	PF02214	BTB_2
# Pfam	PF11404	Potassium_chann
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# RecName	KCNC3_HUMAN	Potassium voltage-gated channel subfamily C member 3
# RefSeq	NP_004968	NM_004977.2
# RefSeq	XP_006723266	XM_006723203.2
# RefSeq	XP_011525228	XM_011526926.1
# SIMILARITY	Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.3/KCNC3 sub-subfamily. {ECO	0000305}.
# SMART	SM00225	BTB
# SUBCELLULAR LOCATION	KCNC3_HUMAN	Cell membrane {ECO 0000269|PubMed 10712820, ECO 0000269|PubMed 16501573, ECO 0000269|PubMed 19953606, ECO 0000269|PubMed 21479265, ECO 0000269|PubMed 22289912, ECO 0000269|PubMed 23734863, ECO 0000269|PubMed 25152487, ECO 0000269|PubMed 25756792, ECO 0000269|PubMed 26997484}; Multi- pass membrane protein {ECO 0000255}. Cell junction, synapse, presynaptic cell membrane {ECO 0000250|UniProtKB Q63959}; Multi- pass membrane protein {ECO 0000255}. Perikaryon {ECO 0000250|UniProtKB Q63959}. Cell projection, axon {ECO 0000250|UniProtKB Q63959}. Cell projection, dendrite {ECO 0000250|UniProtKB Q63959}. Cell projection, dendritic spine membrane {ECO 0000250|UniProtKB Q01956}; Multi-pass membrane protein {ECO 0000255}. Cytoplasm, cell cortex {ECO 0000269|PubMed 26997484}. Cytoplasm, cytoskeleton {ECO 0000269|PubMed 26997484}. Note=Detected on Purkinje cell dendritic spines (By similarity). Detected at presynaptic calices of Held (By similarity). Colocalizes with the cortical actin cytoskeleton and the Arp2/3 complex (PubMed 26997484). {ECO 0000250|UniProtKB Q01956, ECO 0000250|UniProtKB Q63959, ECO 0000269|PubMed 26997484}. 
# SUBUNIT	KCNC3_HUMAN	Homotetramer. Heterotetramer with KCNC1 (PubMed 23734863). Interacts (via C-terminus) with HAX1 (PubMed 26997484). Identified in a complex with ACTR3, a subunit of the Arp2/3 complex; this interaction is indirect and depends on the presence of HAX1 (PubMed 26997484). Interaction with HAX1 modulates channel gating (PubMed 26997484). {ECO 0000269|PubMed 23734863, ECO 0000269|PubMed 26997484}. 
# SUPFAM	SSF54695	SSF54695
# TCDB	1.A.1.2.13	the voltage-gated ion channel (vic) superfamily
# UCSC	uc002pru	human
# eggNOG	COG1226	LUCA
# eggNOG	KOG3713	Eukaryota
BLAST	swissprot:KCNC3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNC3_HUMAN
BioCyc	ZFISH:ENSG00000131398-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000131398-MONOMER
COXPRESdb	3748	http://coxpresdb.jp/data/gene/3748.shtml
CleanEx	HS_KCNC3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNC3
DOI	10.1002/humu.21165	http://dx.doi.org/10.1002/humu.21165
DOI	10.1006/exer.1999.0796	http://dx.doi.org/10.1006/exer.1999.0796
DOI	10.1016/j.cell.2016.02.009	http://dx.doi.org/10.1016/j.cell.2016.02.009
DOI	10.1016/j.nbd.2014.08.020	http://dx.doi.org/10.1016/j.nbd.2014.08.020
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DOI	10.1038/ng1758	http://dx.doi.org/10.1038/ng1758
DOI	10.1042/BJ20130034	http://dx.doi.org/10.1042/BJ20130034
DOI	10.1113/jphysiol.2012.228205	http://dx.doi.org/10.1113/jphysiol.2012.228205
DOI	10.1371/journal.pone.0017811	http://dx.doi.org/10.1371/journal.pone.0017811
DOI	10.1371/journal.pone.0116599	http://dx.doi.org/10.1371/journal.pone.0116599
DrugBank	DB06637	http://www.drugbank.ca/drugs/DB06637
EMBL	AC008655	http://www.ebi.ac.uk/ena/data/view/AC008655
EMBL	AF055989	http://www.ebi.ac.uk/ena/data/view/AF055989
EMBL	Z11585	http://www.ebi.ac.uk/ena/data/view/Z11585
Ensembl	ENST00000477616	http://www.ensembl.org/id/ENST00000477616
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005938	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005938
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030424	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030424
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0032591	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032591
GO_component	GO:0042734	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042734
GO_component	GO:0043204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043204
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:0051262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051262
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	KCNC3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNC3
GeneID	3748	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3748
GeneTree	ENSGT00760000118846	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118846
H-InvDB	HIX0202872	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0202872
HGNC	HGNC:6235	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6235
HOGENOM	HOG000231012	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231012&db=HOGENOM6
HOVERGEN	HBG105862	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG105862&db=HOVERGEN
HPA	HPA018041	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA018041
InParanoid	Q14003	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q14003
InterPro	IPR000210	http://www.ebi.ac.uk/interpro/entry/IPR000210
InterPro	IPR003131	http://www.ebi.ac.uk/interpro/entry/IPR003131
InterPro	IPR003968	http://www.ebi.ac.uk/interpro/entry/IPR003968
InterPro	IPR003974	http://www.ebi.ac.uk/interpro/entry/IPR003974
InterPro	IPR005404	http://www.ebi.ac.uk/interpro/entry/IPR005404
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR011333	http://www.ebi.ac.uk/interpro/entry/IPR011333
InterPro	IPR021105	http://www.ebi.ac.uk/interpro/entry/IPR021105
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	3748	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3748
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00063	http://www.genome.jp/dbget-bin/www_bget?H00063
KEGG_Gene	hsa:3748	http://www.genome.jp/dbget-bin/www_bget?hsa:3748
KEGG_Orthology	KO:K04889	http://www.genome.jp/dbget-bin/www_bget?KO:K04889
MIM	176264	http://www.ncbi.nlm.nih.gov/omim/176264
MIM	605259	http://www.ncbi.nlm.nih.gov/omim/605259
OMA	GTWWRRW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GTWWRRW
Orphanet	98768	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98768
OrthoDB	EOG091G0EJL	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0EJL
PANTHER	PTHR11537	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01491	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01491
PRINTS	PR01498	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01498
PRINTS	PR01582	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01582
PSORT	swissprot:KCNC3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNC3_HUMAN
PSORT-B	swissprot:KCNC3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNC3_HUMAN
PSORT2	swissprot:KCNC3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNC3_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF02214	http://pfam.xfam.org/family/PF02214
Pfam	PF11404	http://pfam.xfam.org/family/PF11404
PharmGKB	PA30027	http://www.pharmgkb.org/do/serve?objId=PA30027&objCls=Gene
Phobius	swissprot:KCNC3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNC3_HUMAN
PhylomeDB	Q14003	http://phylomedb.org/?seqid=Q14003
ProteinModelPortal	Q14003	http://www.proteinmodelportal.org/query/uniprot/Q14003
PubMed	10712820	http://www.ncbi.nlm.nih.gov/pubmed/10712820
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	16501573	http://www.ncbi.nlm.nih.gov/pubmed/16501573
PubMed	19953606	http://www.ncbi.nlm.nih.gov/pubmed/19953606
PubMed	21479265	http://www.ncbi.nlm.nih.gov/pubmed/21479265
PubMed	22289912	http://www.ncbi.nlm.nih.gov/pubmed/22289912
PubMed	23734863	http://www.ncbi.nlm.nih.gov/pubmed/23734863
PubMed	25152487	http://www.ncbi.nlm.nih.gov/pubmed/25152487
PubMed	25756792	http://www.ncbi.nlm.nih.gov/pubmed/25756792
PubMed	26997484	http://www.ncbi.nlm.nih.gov/pubmed/26997484
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
RefSeq	NP_004968	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004968
RefSeq	XP_006723266	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006723266
RefSeq	XP_011525228	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011525228
SMART	SM00225	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225
STRING	9606.ENSP00000434241	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000434241&targetmode=cogs
SUPFAM	SSF54695	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54695
TCDB	1.A.1.2.13	http://www.tcdb.org/search/result.php?tc=1.A.1.2.13
UCSC	uc002pru	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002pru&org=rat
UniGene	Hs.467146	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.467146
UniProtKB	KCNC3_HUMAN	http://www.uniprot.org/uniprot/KCNC3_HUMAN
UniProtKB-AC	Q14003	http://www.uniprot.org/uniprot/Q14003
charge	swissprot:KCNC3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNC3_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG3713	http://eggnogapi.embl.de/nog_data/html/tree/KOG3713
epestfind	swissprot:KCNC3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNC3_HUMAN
garnier	swissprot:KCNC3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNC3_HUMAN
helixturnhelix	swissprot:KCNC3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNC3_HUMAN
hmoment	swissprot:KCNC3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNC3_HUMAN
iep	swissprot:KCNC3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNC3_HUMAN
inforesidue	swissprot:KCNC3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNC3_HUMAN
neXtProt	NX_Q14003	http://www.nextprot.org/db/entry/NX_Q14003
octanol	swissprot:KCNC3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNC3_HUMAN
pepcoil	swissprot:KCNC3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNC3_HUMAN
pepdigest	swissprot:KCNC3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNC3_HUMAN
pepinfo	swissprot:KCNC3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNC3_HUMAN
pepnet	swissprot:KCNC3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNC3_HUMAN
pepstats	swissprot:KCNC3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNC3_HUMAN
pepwheel	swissprot:KCNC3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNC3_HUMAN
pepwindow	swissprot:KCNC3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNC3_HUMAN
sigcleave	swissprot:KCNC3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNC3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SCN9A_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q15858-1; Sequence=Displayed; Name=2; IsoId=Q15858-2; Sequence=VSP_012028; Name=3; IsoId=Q15858-3; Sequence=VSP_012029; Name=4; IsoId=Q15858-4; Sequence=VSP_012028, VSP_012029; 
# AltName	Neuroendocrine sodium channel {ECO:0000303|PubMed	7720699}
# AltName	SCN9A_HUMAN	Peripheral sodium channel 1
# AltName	SCN9A_HUMAN	Sodium channel protein type IX subunit alpha
# AltName	SCN9A_HUMAN	Voltage-gated sodium channel subunit alpha Nav1.7
# CCDS	CCDS46441	-. [Q15858-3]
# DISEASE	SCN9A_HUMAN	Febrile seizures, familial, 3B (FEB3B) [MIM 613863]  Seizures associated with febrile episodes in childhood without any evidence of intracranial infection or defined pathologic or traumatic cause. It is a common condition, affecting 2-5% of children aged 3 months to 5 years. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy. {ECO 0000269|PubMed 19763161}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCN9A_HUMAN	Generalized epilepsy with febrile seizures plus 7 (GEFS+7) [MIM 613863]  A rare autosomal dominant, familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. This disease combines febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity. {ECO 0000269|PubMed 19763161}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCN9A_HUMAN	Indifference to pain, congenital, autosomal recessive (CIP) [MIM 243000]  A disorder characterized by congenital inability to perceive any form of pain, in any part of the body. All other sensory modalities are preserved and the peripheral and central nervous systems are apparently intact. Patients perceive the sensations of touch, warm and cold temperature, proprioception, tickle and pressure, but not painful stimuli. There is no evidence of a motor or sensory neuropathy, either axonal or demyelinating. {ECO 0000269|PubMed 20635406}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCN9A_HUMAN	Paroxysmal extreme pain disorder (PEPD) [MIM 167400]  Autosomal dominant paroxysmal disorder of pain and autonomic dysfunction. The distinctive features are paroxysmal episodes of burning pain in the rectal, ocular, and mandibular areas accompanied by autonomic manifestations such as skin flushing. {ECO 0000269|PubMed 17145499, ECO 0000269|PubMed 18945915, ECO 0000269|PubMed 25285947}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCN9A_HUMAN	Primary erythermalgia (PERYTHM) [MIM 133020]  Autosomal dominant disease characterized by recurrent episodes of severe pain associated with redness and warmth in the feet or hands. {ECO 0000269|PubMed 14985375, ECO 0000269|PubMed 15955112, ECO 0000269|PubMed 15958509, ECO 0000269|PubMed 16216943, ECO 0000269|PubMed 16392115, ECO 0000269|PubMed 18945915, ECO 0000269|PubMed 19369487, ECO 0000269|PubMed 24311784}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	SCN9A_HUMAN	The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position. {ECO 0000305|PubMed 26680203}. 
# DrugBank	DB00243	Ranolazine
# DrugBank	DB00281	Lidocaine
# DrugBank	DB00313	Valproic Acid
# DrugBank	DB00909	Zonisamide
# DrugBank	DB06201	Rufinamide
# DrugBank	DB06218	Lacosamide
# Ensembl	ENST00000303354	ENSP00000304748; ENSG00000169432. [Q15858-1]
# Ensembl	ENST00000409435	ENSP00000386330; ENSG00000169432. [Q15858-1]
# Ensembl	ENST00000409672	ENSP00000386306; ENSG00000169432. [Q15858-3]
# ExpressionAtlas	Q15858	baseline and differential
# FUNCTION	SCN9A_HUMAN	Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed 7720699, PubMed 17167479, PubMed 25240195, PubMed 26680203, PubMed 15385606, PubMed 16988069, PubMed 17145499, PubMed 19369487, PubMed 24311784). It is a tetrodotoxin-sensitive Na(+) channel isoform (PubMed 7720699). Plays a role in pain mechanisms, especially in the development of inflammatory pain (PubMed 17167479, PubMed 17145499, PubMed 19369487, PubMed 24311784). {ECO 0000269|PubMed 15178348, ECO 0000269|PubMed 15385606, ECO 0000269|PubMed 16988069, ECO 0000269|PubMed 17145499, ECO 0000269|PubMed 17167479, ECO 0000269|PubMed 19369487, ECO 0000269|PubMed 24311784, ECO 0000269|PubMed 25240195, ECO 0000269|PubMed 26680203, ECO 0000269|PubMed 7720699}. 
# GO_component	GO:0001518	voltage-gated sodium channel complex; IEA:Ensembl.
# GO_component	GO:0005887	integral component of plasma membrane; IMP:UniProtKB.
# GO_component	GO:0042995	cell projection; IEA:UniProtKB-SubCell.
# GO_function	GO:0005248	voltage-gated sodium channel activity; IDA:UniProtKB.
# GO_function	GO:0031402	sodium ion binding; IEA:Ensembl.
# GO_process	GO:0006814	sodium ion transport; TAS:ProtInc.
# GO_process	GO:0006954	inflammatory response; IEA:Ensembl.
# GO_process	GO:0009636	response to toxic substance; IEA:Ensembl.
# GO_process	GO:0009791	post-embryonic development; IEA:Ensembl.
# GO_process	GO:0019228	neuronal action potential; IBA:GO_Central.
# GO_process	GO:0019233	sensory perception of pain; IMP:UniProtKB.
# GO_process	GO:0035725	sodium ion transmembrane transport; IDA:UniProtKB.
# GO_process	GO:0048266	behavioral response to pain; IEA:Ensembl.
# GO_process	GO:0086010	membrane depolarization during action potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.350	-; 4.
# Genevisible	Q15858	HS
# HGNC	HGNC:10597	SCN9A
# IntAct	Q15858	2
# InterPro	IPR000048	IQ_motif_EF-hand-BS
# InterPro	IPR001696	Na_channel_asu
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR010526	Na_trans_assoc
# InterPro	IPR024583	Na_trans_cytopl
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028803	SCN9A
# KEGG_Brite	ko04040	Ion channels
# KEGG_Disease	H00265	[Nervous system disease] Congenital pain insensitivity with anhidrosis (CIPA/HSAN4)
# KEGG_Disease	H00771	[Cardiovascular disease; Inherited metabolic disease] Primary erythromelalgia
# KEGG_Disease	H00772	[Nervous system disease] Paroxysmal extreme pain disorder (PEPD)
# KEGG_Disease	H00774	[Nervous system disease] Nav1.7-associated congenital insensitivity to pain (CIP)
# KEGG_Disease	H00783	[Nervous system disease; Epilepsy] Dravet syndrome/ Severe myoclonic epilepsy in infancy (SMEI)
# MIM	133020	phenotype
# MIM	167400	phenotype
# MIM	243000	phenotype
# MIM	603415	gene
# MIM	613863	phenotype
# Organism	SCN9A_HUMAN	Homo sapiens (Human)
# Orphanet	1956	Erythromelalgia
# Orphanet	306577	Sodium channelopathy-related small fiber neuropathy
# Orphanet	33069	Dravet syndrome
# Orphanet	36387	Generalized epilepsy with febrile seizures-plus
# Orphanet	46348	Paroxysmal extreme pain disorder
# Orphanet	88642	Channelopathy-associated congenital insensitivity to pain
# Orphanet	90026	Primary erythermalgia
# Orphanet	970	Hereditary sensory and autonomic neuropathy type 2
# PANTHER	PTHR10037:SF221	PTHR10037:SF221; 2
# PDB	5EK0	X-ray; 3.53 A; A/B/C/D=1527-1559, A/B/C/D=1581-1622
# PIR	S54771	S54771
# PRINTS	PR00170	NACHANNEL
# PTM	SCN9A_HUMAN	Phosphorylation at Ser-1490 by PKC in a highly conserved cytoplasmic loop increases peak sodium currents. {ECO 0000269|PubMed 25240195}. 
# PTM	SCN9A_HUMAN	Ubiquitinated by NEDD4L; which may promote its endocytosis. Does not seem to be ubiquitinated by NEDD4. {ECO 0000250|UniProtKB Q62205}. 
# Pfam	PF00520	Ion_trans; 4
# Pfam	PF06512	Na_trans_assoc
# Pfam	PF11933	Na_trans_cytopl
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-445095	Interaction between L1 and Ankyrins
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# RecName	Sodium channel protein type 9 subunit alpha {ECO	0000305}
# RefSeq	NP_002968	NM_002977.3
# RefSeq	XP_005246814	XM_005246757.2. [Q15858-1]
# RefSeq	XP_011509918	XM_011511616.2. [Q15858-1]
# RefSeq	XP_011509919	XM_011511617.2. [Q15858-2]
# RefSeq	XP_011509920	XM_011511618.2. [Q15858-4]
# SIMILARITY	Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.7/SCN9A subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 IQ domain. {ECO	0000305}. 
# SMART	SM00015	IQ
# SUBCELLULAR LOCATION	SCN9A_HUMAN	Cell membrane {ECO 0000269|PubMed 15385606, ECO 0000269|PubMed 17167479, ECO 0000269|PubMed 19369487, ECO 0000269|PubMed 24311784, ECO 0000269|PubMed 25240195, ECO 0000269|PubMed 26680203, ECO 0000269|PubMed 7720699}; Multi- pass membrane protein {ECO 0000305}. Cell projection {ECO 0000250|UniProtKB O08562}. Note=In neurite terminals. {ECO 0000250|UniProtKB O08562}. 
# SUBUNIT	SCN9A_HUMAN	The sodium channel complex consists of a large, channel- forming alpha subunit and 2-3 smaller, ancillary beta subunits (PubMed 7720699, PubMed 17167479, PubMed 25240195). Interacts with NEDD4 and NEDD4L (By similarity). {ECO 0000250|UniProtKB Q62205, ECO 0000269|PubMed 17167479, ECO 0000269|PubMed 25240195, ECO 0000269|PubMed 7720699}. 
# TCDB	1.A.1.10	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	SCN9A_HUMAN	Expressed strongly in dorsal root ganglion, with only minor levels elsewhere in the body, smooth muscle cells, MTC cell line and C-cell carcinoma. Isoform 1 is expressed preferentially in the central and peripheral nervous system. Isoform 2 is expressed preferentially in the dorsal root ganglion. {ECO 0000269|PubMed 15178348, ECO 0000269|PubMed 15302875, ECO 0000269|PubMed 7720699, ECO 0000269|PubMed 9169448}. 
# UCSC	uc002udr	human. [Q15858-1]
# WEB RESOURCE	SCN9A_HUMAN	Name=Protein Spotlight; Note=Silent pain - Issue 102 of February 2009; URL="http //web.expasy.org/spotlight/back_issues/102";
# WEB RESOURCE	SCN9A_HUMAN	Name=Wikipedia; Note=SCN9A entry; URL="https //en.wikipedia.org/wiki/SCN9A"; 
# eggNOG	ENOG410XNP6	LUCA
# eggNOG	KOG2301	Eukaryota
BLAST	swissprot:SCN9A_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SCN9A_HUMAN
BioCyc	ZFISH:ENSG00000169432-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000169432-MONOMER
COXPRESdb	6335	http://coxpresdb.jp/data/gene/6335.shtml
CleanEx	HS_SCN9A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SCN9A
DOI	10.1001/archneur.62.10.1587	http://dx.doi.org/10.1001/archneur.62.10.1587
DOI	10.1002/ana.20776	http://dx.doi.org/10.1002/ana.20776
DOI	10.1002/humu.21325	http://dx.doi.org/10.1002/humu.21325
DOI	10.1016/j.febslet.2004.04.092	http://dx.doi.org/10.1016/j.febslet.2004.04.092
DOI	10.1016/j.febslet.2014.09.011	http://dx.doi.org/10.1016/j.febslet.2014.09.011
DOI	10.1016/j.neuron.2006.10.006	http://dx.doi.org/10.1016/j.neuron.2006.10.006
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/nature05413	http://dx.doi.org/10.1038/nature05413
DOI	10.1073/pnas.0602813103	http://dx.doi.org/10.1073/pnas.0602813103
DOI	10.1074/jbc.272.23.14805	http://dx.doi.org/10.1074/jbc.272.23.14805
DOI	10.1074/jbc.M113.502211	http://dx.doi.org/10.1074/jbc.M113.502211
DOI	10.1074/jbc.M406387200	http://dx.doi.org/10.1074/jbc.M406387200
DOI	10.1093/brain/awh514	http://dx.doi.org/10.1093/brain/awh514
DOI	10.1093/brain/awp078	http://dx.doi.org/10.1093/brain/awp078
DOI	10.1097/ALN.0000000000000476	http://dx.doi.org/10.1097/ALN.0000000000000476
DOI	10.1111/j.0022-202X.2005.23737.x	http://dx.doi.org/10.1111/j.0022-202X.2005.23737.x
DOI	10.1126/science.aac5464	http://dx.doi.org/10.1126/science.aac5464
DOI	10.1136/jmg.2003.012153	http://dx.doi.org/10.1136/jmg.2003.012153
DOI	10.1212/01.wnl.0000231514.33603.1e	http://dx.doi.org/10.1212/01.wnl.0000231514.33603.1e
DOI	10.1371/journal.pgen.1000649	http://dx.doi.org/10.1371/journal.pgen.1000649
DOI	10.1523/JNEUROSCI.2695-04.2004	http://dx.doi.org/10.1523/JNEUROSCI.2695-04.2004
DOI	10.1523/JNEUROSCI.3443-08.2008	http://dx.doi.org/10.1523/JNEUROSCI.3443-08.2008
DrugBank	DB00243	http://www.drugbank.ca/drugs/DB00243
DrugBank	DB00281	http://www.drugbank.ca/drugs/DB00281
DrugBank	DB00313	http://www.drugbank.ca/drugs/DB00313
DrugBank	DB00909	http://www.drugbank.ca/drugs/DB00909
DrugBank	DB06201	http://www.drugbank.ca/drugs/DB06201
DrugBank	DB06218	http://www.drugbank.ca/drugs/DB06218
EMBL	AC074101	http://www.ebi.ac.uk/ena/data/view/AC074101
EMBL	AC107082	http://www.ebi.ac.uk/ena/data/view/AC107082
EMBL	AC108146	http://www.ebi.ac.uk/ena/data/view/AC108146
EMBL	AJ310882	http://www.ebi.ac.uk/ena/data/view/AJ310882
EMBL	AJ310883	http://www.ebi.ac.uk/ena/data/view/AJ310883
EMBL	AJ310897	http://www.ebi.ac.uk/ena/data/view/AJ310897
EMBL	AJ580918	http://www.ebi.ac.uk/ena/data/view/AJ580918
EMBL	AJ580919	http://www.ebi.ac.uk/ena/data/view/AJ580919
EMBL	AY682084	http://www.ebi.ac.uk/ena/data/view/AY682084
EMBL	AY682085	http://www.ebi.ac.uk/ena/data/view/AY682085
EMBL	AY682086	http://www.ebi.ac.uk/ena/data/view/AY682086
EMBL	DQ857292	http://www.ebi.ac.uk/ena/data/view/DQ857292
EMBL	X82835	http://www.ebi.ac.uk/ena/data/view/X82835
Ensembl	ENST00000303354	http://www.ensembl.org/id/ENST00000303354
Ensembl	ENST00000409435	http://www.ensembl.org/id/ENST00000409435
Ensembl	ENST00000409672	http://www.ensembl.org/id/ENST00000409672
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0001518	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001518
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0042995	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042995
GO_function	GO:0005248	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005248
GO_function	GO:0031402	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031402
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0006954	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006954
GO_process	GO:0009636	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009636
GO_process	GO:0009791	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009791
GO_process	GO:0019228	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019228
GO_process	GO:0019233	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019233
GO_process	GO:0035725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035725
GO_process	GO:0048266	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048266
GO_process	GO:0086010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086010
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	SCN9A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SCN9A
GeneID	6335	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6335
GeneTree	ENSGT00830000128242	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00830000128242
HGNC	HGNC:10597	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10597
HOVERGEN	HBG053100	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053100&db=HOVERGEN
HPA	CAB013679	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB013679
HPA	HPA061843	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA061843
InParanoid	Q15858	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q15858
IntAct	Q15858	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q15858*
InterPro	IPR000048	http://www.ebi.ac.uk/interpro/entry/IPR000048
InterPro	IPR001696	http://www.ebi.ac.uk/interpro/entry/IPR001696
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR010526	http://www.ebi.ac.uk/interpro/entry/IPR010526
InterPro	IPR024583	http://www.ebi.ac.uk/interpro/entry/IPR024583
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028803	http://www.ebi.ac.uk/interpro/entry/IPR028803
Jabion	6335	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6335
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00265	http://www.genome.jp/dbget-bin/www_bget?H00265
KEGG_Disease	H00771	http://www.genome.jp/dbget-bin/www_bget?H00771
KEGG_Disease	H00772	http://www.genome.jp/dbget-bin/www_bget?H00772
KEGG_Disease	H00774	http://www.genome.jp/dbget-bin/www_bget?H00774
KEGG_Disease	H00783	http://www.genome.jp/dbget-bin/www_bget?H00783
KEGG_Gene	hsa:6335	http://www.genome.jp/dbget-bin/www_bget?hsa:6335
KEGG_Orthology	KO:K04841	http://www.genome.jp/dbget-bin/www_bget?KO:K04841
MIM	133020	http://www.ncbi.nlm.nih.gov/omim/133020
MIM	167400	http://www.ncbi.nlm.nih.gov/omim/167400
MIM	243000	http://www.ncbi.nlm.nih.gov/omim/243000
MIM	603415	http://www.ncbi.nlm.nih.gov/omim/603415
MIM	613863	http://www.ncbi.nlm.nih.gov/omim/613863
OMA	VSQNVRW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VSQNVRW
Orphanet	1956	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1956
Orphanet	306577	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=306577
Orphanet	33069	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=33069
Orphanet	36387	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=36387
Orphanet	46348	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=46348
Orphanet	88642	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=88642
Orphanet	90026	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=90026
Orphanet	970	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=970
OrthoDB	EOG091G00FK	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00FK
PANTHER	PTHR10037:SF221	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10037:SF221
PDB	5EK0	http://www.ebi.ac.uk/pdbe-srv/view/entry/5EK0
PDBsum	5EK0	http://www.ebi.ac.uk/pdbsum/5EK0
PRINTS	PR00170	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00170
PSORT	swissprot:SCN9A_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SCN9A_HUMAN
PSORT-B	swissprot:SCN9A_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SCN9A_HUMAN
PSORT2	swissprot:SCN9A_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SCN9A_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF06512	http://pfam.xfam.org/family/PF06512
Pfam	PF11933	http://pfam.xfam.org/family/PF11933
PharmGKB	PA35010	http://www.pharmgkb.org/do/serve?objId=PA35010&objCls=Gene
Phobius	swissprot:SCN9A_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SCN9A_HUMAN
PhylomeDB	Q15858	http://phylomedb.org/?seqid=Q15858
ProteinModelPortal	Q15858	http://www.proteinmodelportal.org/query/uniprot/Q15858
PubMed	14985375	http://www.ncbi.nlm.nih.gov/pubmed/14985375
PubMed	15178348	http://www.ncbi.nlm.nih.gov/pubmed/15178348
PubMed	15302875	http://www.ncbi.nlm.nih.gov/pubmed/15302875
PubMed	15385606	http://www.ncbi.nlm.nih.gov/pubmed/15385606
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	15955112	http://www.ncbi.nlm.nih.gov/pubmed/15955112
PubMed	15958509	http://www.ncbi.nlm.nih.gov/pubmed/15958509
PubMed	16216943	http://www.ncbi.nlm.nih.gov/pubmed/16216943
PubMed	16392115	http://www.ncbi.nlm.nih.gov/pubmed/16392115
PubMed	16702558	http://www.ncbi.nlm.nih.gov/pubmed/16702558
PubMed	16988069	http://www.ncbi.nlm.nih.gov/pubmed/16988069
PubMed	17145499	http://www.ncbi.nlm.nih.gov/pubmed/17145499
PubMed	17167479	http://www.ncbi.nlm.nih.gov/pubmed/17167479
PubMed	18945915	http://www.ncbi.nlm.nih.gov/pubmed/18945915
PubMed	19369487	http://www.ncbi.nlm.nih.gov/pubmed/19369487
PubMed	19763161	http://www.ncbi.nlm.nih.gov/pubmed/19763161
PubMed	20635406	http://www.ncbi.nlm.nih.gov/pubmed/20635406
PubMed	24311784	http://www.ncbi.nlm.nih.gov/pubmed/24311784
PubMed	25240195	http://www.ncbi.nlm.nih.gov/pubmed/25240195
PubMed	25285947	http://www.ncbi.nlm.nih.gov/pubmed/25285947
PubMed	26680203	http://www.ncbi.nlm.nih.gov/pubmed/26680203
PubMed	7720699	http://www.ncbi.nlm.nih.gov/pubmed/7720699
PubMed	9169448	http://www.ncbi.nlm.nih.gov/pubmed/9169448
Reactome	R-HSA-445095	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-445095
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
RefSeq	NP_002968	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002968
RefSeq	XP_005246814	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005246814
RefSeq	XP_011509918	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011509918
RefSeq	XP_011509919	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011509919
RefSeq	XP_011509920	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011509920
SMART	SM00015	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00015
SMR	Q15858	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q15858
STRING	9606.ENSP00000386306	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000386306&targetmode=cogs
TCDB	1.A.1.10	http://www.tcdb.org/search/result.php?tc=1.A.1.10
UCSC	uc002udr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002udr&org=rat
UniGene	Hs.439145	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.439145
UniProtKB	SCN9A_HUMAN	http://www.uniprot.org/uniprot/SCN9A_HUMAN
UniProtKB-AC	Q15858	http://www.uniprot.org/uniprot/Q15858
charge	swissprot:SCN9A_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SCN9A_HUMAN
eggNOG	ENOG410XNP6	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNP6
eggNOG	KOG2301	http://eggnogapi.embl.de/nog_data/html/tree/KOG2301
epestfind	swissprot:SCN9A_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SCN9A_HUMAN
garnier	swissprot:SCN9A_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SCN9A_HUMAN
helixturnhelix	swissprot:SCN9A_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SCN9A_HUMAN
hmoment	swissprot:SCN9A_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SCN9A_HUMAN
iep	swissprot:SCN9A_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SCN9A_HUMAN
inforesidue	swissprot:SCN9A_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SCN9A_HUMAN
neXtProt	NX_Q15858	http://www.nextprot.org/db/entry/NX_Q15858
octanol	swissprot:SCN9A_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SCN9A_HUMAN
pepcoil	swissprot:SCN9A_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SCN9A_HUMAN
pepdigest	swissprot:SCN9A_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SCN9A_HUMAN
pepinfo	swissprot:SCN9A_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SCN9A_HUMAN
pepnet	swissprot:SCN9A_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SCN9A_HUMAN
pepstats	swissprot:SCN9A_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SCN9A_HUMAN
pepwheel	swissprot:SCN9A_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SCN9A_HUMAN
pepwindow	swissprot:SCN9A_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SCN9A_HUMAN
sigcleave	swissprot:SCN9A_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SCN9A_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AP4S1_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9Y587-1; Sequence=Displayed; Name=2; IsoId=Q9Y587-2; Sequence=VSP_040023; Name=3; IsoId=Q9Y587-3; Sequence=VSP_046364; Note=No experimental confirmation available.; Name=4; IsoId=Q9Y587-4; Sequence=VSP_046941; 
# AltName	AP4S1_HUMAN	AP-4 adaptor complex subunit sigma-1
# AltName	AP4S1_HUMAN	Adaptor-related protein complex 4 subunit sigma-1
# AltName	AP4S1_HUMAN	Sigma-1 subunit of AP-4
# AltName	AP4S1_HUMAN	Sigma-4-adaptin
# BioGrid	116325	21
# CCDS	CCDS45093	-. [Q9Y587-1]
# CCDS	CCDS58309	-. [Q9Y587-4]
# CCDS	CCDS58310	-. [Q9Y587-3]
# CCDS	CCDS9642	-. [Q9Y587-2]
# ChiTaRS	AP4S1	human
# DISEASE	AP4S1_HUMAN	Spastic paraplegia 52, autosomal recessive (SPG52) [MIM 614067]  A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. SPG52 is characterized by neonatal hypotonia that progresses to hypertonia and spasticity, and severe mental retardation with poor or absent speech development. Some patients may have seizures. {ECO 0000269|PubMed 21620353}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000216366	ENSP00000216366; ENSG00000100478. [Q9Y587-2]
# Ensembl	ENST00000313566	ENSP00000322508; ENSG00000100478. [Q9Y587-4]
# Ensembl	ENST00000334725	ENSP00000334484; ENSG00000100478. [Q9Y587-4]
# Ensembl	ENST00000542754	ENSP00000438170; ENSG00000100478. [Q9Y587-1]
# Ensembl	ENST00000554345	ENSP00000450768; ENSG00000100478. [Q9Y587-3]
# Ensembl	ENST00000616371	ENSP00000477631; ENSG00000100478. [Q9Y587-1]
# Ensembl	ENST00000622409	ENSP00000482876; ENSG00000100478. [Q9Y587-1]
# ExpressionAtlas	Q9Y587	baseline and differential
# FUNCTION	AP4S1_HUMAN	Subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. 
# GO_component	GO:0005905	clathrin-coated pit; IEA:UniProtKB-SubCell.
# GO_component	GO:0031904	endosome lumen; TAS:Reactome.
# GO_component	GO:0032588	trans-Golgi network membrane; TAS:Reactome.
# GO_function	GO:0005215	transporter activity; TAS:ProtInc.
# GO_function	GO:0008565	protein transporter activity; IEA:InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008565	protein transporter activity
# Genevisible	Q9Y587	HS
# HGNC	HGNC:575	AP4S1
# IntAct	Q9Y587	19
# InterPro	IPR011012	Longin-like_dom
# InterPro	IPR016635	AP_complex_ssu
# InterPro	IPR022775	AP_mu_sigma_su
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Disease	H01097	[Nervous system disease] Cerebral palsy
# KEGG_Pathway	ko04142	Lysosome
# MIM	607243	gene
# MIM	614067	phenotype
# Organism	AP4S1_HUMAN	Homo sapiens (Human)
# Orphanet	280763	Severe intellectual disability and progressive spastic paraplegia
# PANTHER	PTHR11753	PTHR11753
# PIRSF	PIRSF015588	AP_complex_sigma
# Pfam	PF01217	Clat_adaptor_s
# Proteomes	UP000005640	Chromosome 14
# Reactome	R-HSA-432720	Lysosome Vesicle Biogenesis
# RecName	AP4S1_HUMAN	AP-4 complex subunit sigma-1
# RefSeq	NP_001121598	NM_001128126.2. [Q9Y587-1]
# RefSeq	NP_001241655	NM_001254726.1. [Q9Y587-3]
# RefSeq	NP_001241656	NM_001254727.1. [Q9Y587-4]
# RefSeq	NP_001241657	NM_001254728.1. [Q9Y587-1]
# RefSeq	NP_001241658	NM_001254729.1. [Q9Y587-1]
# RefSeq	NP_009008	NM_007077.4. [Q9Y587-2]
# RefSeq	XP_005267350	XM_005267293.4. [Q9Y587-2]
# RefSeq	XP_011534673	XM_011536371.2. [Q9Y587-2]
# RefSeq	XP_011534674	XM_011536372.2. [Q9Y587-2]
# SIMILARITY	Belongs to the adaptor complexes small subunit family. {ECO	0000305}.
# SUBCELLULAR LOCATION	AP4S1_HUMAN	Golgi apparatus, trans-Golgi network. Membrane, coated pit. Note=Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells. 
# SUBUNIT	AP4S1_HUMAN	Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunitAP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1). 
# SUPFAM	SSF64356	SSF64356
# TISSUE SPECIFICITY	AP4S1_HUMAN	Widely expressed. 
# UCSC	uc001wqw	human. [Q9Y587-1]
# eggNOG	COG5030	LUCA
# eggNOG	KOG0934	Eukaryota
BLAST	swissprot:AP4S1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AP4S1_HUMAN
BioCyc	ZFISH:ENSG00000100478-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000100478-MONOMER
COXPRESdb	11154	http://coxpresdb.jp/data/gene/11154.shtml
CleanEx	HS_AP4S1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AP4S1
DOI	10.1016/j.ajhg.2011.04.019	http://dx.doi.org/10.1016/j.ajhg.2011.04.019
DOI	10.1038/nature01348	http://dx.doi.org/10.1038/nature01348
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1091/mbc.10.8.2787	http://dx.doi.org/10.1091/mbc.10.8.2787
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB030654	http://www.ebi.ac.uk/ena/data/view/AB030654
EMBL	AF155159	http://www.ebi.ac.uk/ena/data/view/AF155159
EMBL	AK304115	http://www.ebi.ac.uk/ena/data/view/AK304115
EMBL	AL049830	http://www.ebi.ac.uk/ena/data/view/AL049830
EMBL	AL121808	http://www.ebi.ac.uk/ena/data/view/AL121808
EMBL	BC001259	http://www.ebi.ac.uk/ena/data/view/BC001259
EMBL	BT006701	http://www.ebi.ac.uk/ena/data/view/BT006701
EMBL	BX247969	http://www.ebi.ac.uk/ena/data/view/BX247969
EMBL	BX388185	http://www.ebi.ac.uk/ena/data/view/BX388185
EMBL	CH471078	http://www.ebi.ac.uk/ena/data/view/CH471078
EMBL	CH471078	http://www.ebi.ac.uk/ena/data/view/CH471078
EMBL	CH471078	http://www.ebi.ac.uk/ena/data/view/CH471078
EMBL	CR457100	http://www.ebi.ac.uk/ena/data/view/CR457100
Ensembl	ENST00000216366	http://www.ensembl.org/id/ENST00000216366
Ensembl	ENST00000313566	http://www.ensembl.org/id/ENST00000313566
Ensembl	ENST00000334725	http://www.ensembl.org/id/ENST00000334725
Ensembl	ENST00000542754	http://www.ensembl.org/id/ENST00000542754
Ensembl	ENST00000554345	http://www.ensembl.org/id/ENST00000554345
Ensembl	ENST00000616371	http://www.ensembl.org/id/ENST00000616371
Ensembl	ENST00000622409	http://www.ensembl.org/id/ENST00000622409
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005905	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005905
GO_component	GO:0031904	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031904
GO_component	GO:0032588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032588
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GeneCards	AP4S1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=AP4S1
GeneID	11154	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11154
GeneTree	ENSGT00530000062839	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062839
HGNC	HGNC:575	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:575
HOGENOM	HOG000185227	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000185227&db=HOGENOM6
HOVERGEN	HBG050517	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050517&db=HOVERGEN
HPA	HPA039963	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA039963
InParanoid	Q9Y587	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y587
IntAct	Q9Y587	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9Y587*
InterPro	IPR011012	http://www.ebi.ac.uk/interpro/entry/IPR011012
InterPro	IPR016635	http://www.ebi.ac.uk/interpro/entry/IPR016635
InterPro	IPR022775	http://www.ebi.ac.uk/interpro/entry/IPR022775
Jabion	11154	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=11154
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Disease	H01097	http://www.genome.jp/dbget-bin/www_bget?H01097
KEGG_Gene	hsa:11154	http://www.genome.jp/dbget-bin/www_bget?hsa:11154
KEGG_Orthology	KO:K12403	http://www.genome.jp/dbget-bin/www_bget?KO:K12403
KEGG_Pathway	ko04142	http://www.genome.jp/kegg-bin/show_pathway?ko04142
MIM	607243	http://www.ncbi.nlm.nih.gov/omim/607243
MIM	614067	http://www.ncbi.nlm.nih.gov/omim/614067
OMA	KLVYRQY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KLVYRQY
Orphanet	280763	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=280763
OrthoDB	EOG091G0OOD	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0OOD
PANTHER	PTHR11753	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11753
PSORT	swissprot:AP4S1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AP4S1_HUMAN
PSORT-B	swissprot:AP4S1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AP4S1_HUMAN
PSORT2	swissprot:AP4S1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AP4S1_HUMAN
Pfam	PF01217	http://pfam.xfam.org/family/PF01217
PharmGKB	PA24867	http://www.pharmgkb.org/do/serve?objId=PA24867&objCls=Gene
Phobius	swissprot:AP4S1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AP4S1_HUMAN
PhylomeDB	Q9Y587	http://phylomedb.org/?seqid=Q9Y587
ProteinModelPortal	Q9Y587	http://www.proteinmodelportal.org/query/uniprot/Q9Y587
PubMed	10436028	http://www.ncbi.nlm.nih.gov/pubmed/10436028
PubMed	12508121	http://www.ncbi.nlm.nih.gov/pubmed/12508121
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21620353	http://www.ncbi.nlm.nih.gov/pubmed/21620353
Reactome	R-HSA-432720	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432720
RefSeq	NP_001121598	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001121598
RefSeq	NP_001241655	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001241655
RefSeq	NP_001241656	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001241656
RefSeq	NP_001241657	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001241657
RefSeq	NP_001241658	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001241658
RefSeq	NP_009008	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_009008
RefSeq	XP_005267350	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005267350
RefSeq	XP_011534673	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011534673
RefSeq	XP_011534674	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011534674
SMR	Q9Y587	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9Y587
STRING	9606.ENSP00000216366	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000216366&targetmode=cogs
SUPFAM	SSF64356	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF64356
UCSC	uc001wqw	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001wqw&org=rat
UniGene	Hs.293411	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.293411
UniProtKB	AP4S1_HUMAN	http://www.uniprot.org/uniprot/AP4S1_HUMAN
UniProtKB-AC	Q9Y587	http://www.uniprot.org/uniprot/Q9Y587
charge	swissprot:AP4S1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AP4S1_HUMAN
eggNOG	COG5030	http://eggnogapi.embl.de/nog_data/html/tree/COG5030
eggNOG	KOG0934	http://eggnogapi.embl.de/nog_data/html/tree/KOG0934
epestfind	swissprot:AP4S1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AP4S1_HUMAN
garnier	swissprot:AP4S1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AP4S1_HUMAN
helixturnhelix	swissprot:AP4S1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AP4S1_HUMAN
hmoment	swissprot:AP4S1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AP4S1_HUMAN
iep	swissprot:AP4S1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AP4S1_HUMAN
inforesidue	swissprot:AP4S1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AP4S1_HUMAN
neXtProt	NX_Q9Y587	http://www.nextprot.org/db/entry/NX_Q9Y587
octanol	swissprot:AP4S1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AP4S1_HUMAN
pepcoil	swissprot:AP4S1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AP4S1_HUMAN
pepdigest	swissprot:AP4S1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AP4S1_HUMAN
pepinfo	swissprot:AP4S1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AP4S1_HUMAN
pepnet	swissprot:AP4S1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AP4S1_HUMAN
pepstats	swissprot:AP4S1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AP4S1_HUMAN
pepwheel	swissprot:AP4S1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AP4S1_HUMAN
pepwindow	swissprot:AP4S1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AP4S1_HUMAN
sigcleave	swissprot:AP4S1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AP4S1_HUMAN
## Database	ID	URL or Descriptions
# AltName	SCN4A_HUMAN	SkM1
# AltName	SCN4A_HUMAN	Sodium channel protein skeletal muscle subunit alpha
# AltName	SCN4A_HUMAN	Sodium channel protein type IV subunit alpha
# AltName	SCN4A_HUMAN	Voltage-gated sodium channel subunit alpha Nav1.4
# BioGrid	112234	4
# ChiTaRS	SCN4A	human
# DISEASE	SCN4A_HUMAN	Myasthenic syndrome, congenital, 16 (CMS16) [MIM 614198]  A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness. CMS16 is characterized by fatigable generalized weakness and recurrent attacks of respiratory and bulbar paralysis since birth. The fatigable weakness involves lid-elevator, external ocular, facial, limb and truncal muscles and an decremental response of the compound muscle action potential on repetitive stimulation. {ECO 0000269|PubMed 12766226, ECO 0000269|PubMed 25707578, ECO 0000269|PubMed 26659129}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCN4A_HUMAN	Myotonia SCN4A-related (MYOSCN4A) [MIM 608390]  A phenotypically highly variable myotonia aggravated by potassium loading, and sometimes by cold. Myotonia is characterized by sustained muscle tensing that prevents muscles from relaxing normally. It causes muscle stiffness that can interfere with movement. In some people the stiffness is very mild, while in other cases it may be severe enough to interfere with walking, running, and other activities of daily life. Myotonia SCN4A- related includes myotonia permanens and myotonia fluctuans. In myotonia permanens, the myotonia is generalized and there is a hypertrophy of the muscle, particularly in the neck and the shoulder. Attacks of severe muscle stiffness of the thoracic muscles may be life threatening due to impaired ventilation. In myotonia fluctuans, the muscle stiffness may fluctuate from day to day, provoked by exercise. {ECO 0000269|PubMed 10218481, ECO 0000269|PubMed 16786525, ECO 0000269|PubMed 16832098, ECO 0000269|PubMed 17212350, ECO 0000269|PubMed 17998485, ECO 0000269|PubMed 18203179, ECO 0000269|PubMed 18337100, ECO 0000269|PubMed 19015483, ECO 0000269|PubMed 19347921, ECO 0000269|PubMed 20076800, ECO 0000269|PubMed 8058156, ECO 0000269|PubMed 9392583}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCN4A_HUMAN	Note=SCN4A mutations are the cause of an autosomal recessive neuromuscular disorder characterized by severe fetal hypokinesia, neonatal hypotonia and congenital myopathy of variable severity. The most severe clinical features include reduced or absent fetal movements, in-utero upper and lower limb contractures, talipes and hydrops, and intrauterine or early postnatal death. Mildly affected patients present with generalized hypotonia and weakness at birth or within the first few days of life, mild-to-moderate facial muscle weakness without ptosis, significant early respiratory and feeding difficulties, and skeletal abnormalities of the spine and palate. Symptoms improve over time in patients who survive infancy, resulting in gain of muscle strength and motor skills and concomitant resolution of early respiratory and feeding difficulties. In contrast to other SCN4A-related channelopathies, affected individuals manifest in- utero or neonatal onset of permanent muscle weakness, rather than later-onset episodic muscle weakness. {ECO 0000269|PubMed 26700687}. 
# DISEASE	SCN4A_HUMAN	Paramyotonia congenita of von Eulenburg (PMC) [MIM 168300]  An autosomal dominant channelopathy characterized by myotonia, increased by exposure to cold, intermittent flaccid paresis, not necessarily dependent on cold or myotonia, lability of serum potassium, non-progressive nature and lack of atrophy or hypertrophy of muscles. In some patients, myotonia is not increased by cold exposure (paramyotonia without cold paralysis). Patients may have a combination phenotype of PMC and HYPP. {ECO 0000269|PubMed 10369308, ECO 0000269|PubMed 10727489, ECO 0000269|PubMed 1310898, ECO 0000269|PubMed 1316765, ECO 0000269|PubMed 1338909, ECO 0000269|PubMed 15318338, ECO 0000269|PubMed 15790667, ECO 0000269|PubMed 16786525, ECO 0000269|PubMed 18166706, ECO 0000269|PubMed 19077043, ECO 0000269|PubMed 20076800, ECO 0000269|PubMed 8242056, ECO 0000269|PubMed 8308722, ECO 0000269|PubMed 8388676, ECO 0000269|PubMed 8580427}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCN4A_HUMAN	Periodic paralysis hyperkalemic (HYPP) [MIM 170500]  An autosomal dominant channelopathy characterized by episodic flaccid generalized muscle weakness associated with high levels of serum potassium. Concurrence of myotonia is found in HYPP patients. {ECO 0000269|PubMed 1659668, ECO 0000269|PubMed 1659948, ECO 0000269|PubMed 20076800}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCN4A_HUMAN	Periodic paralysis hypokalemic 2 (HOKPP2) [MIM 613345]  An autosomal dominant disorder manifested by episodic flaccid generalized muscle weakness associated with falls of serum potassium levels. {ECO 0000269|PubMed 10599760, ECO 0000269|PubMed 10851391, ECO 0000269|PubMed 10944223, ECO 0000269|PubMed 11558801, ECO 0000269|PubMed 11591859, ECO 0000269|PubMed 16890191, ECO 0000269|PubMed 17898326, ECO 0000269|PubMed 18162704, ECO 0000269|PubMed 19118277, ECO 0000269|PubMed 20522878, ECO 0000269|PubMed 21043388, ECO 0000269|PubMed 24549961}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCN4A_HUMAN	Periodic paralysis normokalemic (NKPP) [MIM 170500]  A disorder closely related to hyperkalemic periodic paralysis, but marked by a lack of alterations in potassium levels during attacks of muscle weakness. {ECO 0000269|PubMed 15596759, ECO 0000269|PubMed 18046642, ECO 0000269|PubMed 20522878}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	SCN4A_HUMAN	The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position. 
# DrugBank	DB00313	Valproic Acid
# DrugBank	DB00586	Diclofenac
# DrugBank	DB00818	Propofol
# DrugBank	DB00909	Zonisamide
# DrugBank	DB01195	Flecainide
# Ensembl	ENST00000435607	ENSP00000396320; ENSG00000007314
# ExpressionAtlas	P35499	baseline and differential
# FUNCTION	SCN4A_HUMAN	This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. This sodium channel may be present in both denervated and innervated skeletal muscle. {ECO 0000269|PubMed 15318338, ECO 0000269|PubMed 16890191}. 
# GO_component	GO:0001518	voltage-gated sodium channel complex; IEA:InterPro.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_function	GO:0005248	voltage-gated sodium channel activity; TAS:ProtInc.
# GO_process	GO:0006814	sodium ion transport; TAS:ProtInc.
# GO_process	GO:0006936	muscle contraction; TAS:ProtInc.
# GO_process	GO:0019228	neuronal action potential; IBA:GO_Central.
# GO_process	GO:0086010	membrane depolarization during action potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.20.120.350	-; 4.
# Genevisible	P35499	HS
# HGNC	HGNC:10591	SCN4A
# InterPro	IPR000048	IQ_motif_EF-hand-BS
# InterPro	IPR001696	Na_channel_asu
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR008052	Na_channel_a4su_mammal
# InterPro	IPR010526	Na_trans_assoc
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028826	Na_channel_a4su
# KEGG_Brite	ko04040	Ion channels
# KEGG_Disease	H00215:[Inherited metabolic disease; Nervous system disease; Muscular disease] Andersen-Tawil syndrome (ATS) [DS	H00748]
# KEGG_Disease	H00743	[Musculoskeletal disease; Nervous system disease] Paramyotonia congenita (PMC)
# KEGG_Disease	H00744	[Musculoskeletal disease; Nervous system disease] Acetazolamide responsive myotonia
# KEGG_Disease	H00745	[Musculoskeletal disease; Nervous system disease; Inherited metabolic disease] Hyperkalemic periodic paralysis (HyperPP)
# KEGG_Disease	H00746	[Musculoskeletal disease; Nervous system disease; Inherited metabolic disease] Hypokalemic periodic paralysis (HypoPP)
# KEGG_Disease	H00770	[Nervous system disease] Congenital myasthenic syndrome
# MIM	168300	phenotype
# MIM	170500	phenotype
# MIM	603967	gene
# MIM	608390	phenotype
# MIM	613345	phenotype
# MIM	614198	phenotype
# Organism	SCN4A_HUMAN	Homo sapiens (Human)
# Orphanet	681	Hypokalemic periodic paralysis
# Orphanet	682	Hyperkalemic periodic paralysis
# Orphanet	684	Paramyotonia congenita of Von Eulenburg
# Orphanet	98913	Postsynaptic congenital myasthenic syndromes
# Orphanet	99734	Myotonia fluctuans
# Orphanet	99735	Myotonia permanens
# Orphanet	99736	Acetazolamide-responsive myotonia
# PANTHER	PTHR10037:SF223	PTHR10037:SF223; 2
# PIR	I51964	I51964
# PIR	I54323	I54323
# PIR	I64893	I64893
# PIR	JS0648	JS0648
# PRINTS	PR00170	NACHANNEL
# PRINTS	PR01665	NACHANNEL4
# PROSITE	PS50096	IQ
# PTM	SCN4A_HUMAN	Phosphorylation at Ser-1328 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents. {ECO 0000250}. 
# Pfam	PF00520	Ion_trans; 4
# Pfam	PF06512	Na_trans_assoc
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-445095	Interaction between L1 and Ankyrins
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# RecName	SCN4A_HUMAN	Sodium channel protein type 4 subunit alpha
# RefSeq	NP_000325	NM_000334.4
# SIMILARITY	Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.4/SCN4A subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 IQ domain. {ECO:0000255|PROSITE- ProRule	PRU00116}. 
# SUBCELLULAR LOCATION	SCN4A_HUMAN	Cell membrane {ECO 0000269|PubMed 15318338, ECO 0000269|PubMed 16890191}; Multi-pass membrane protein {ECO 0000305}. 
# SUBUNIT	Muscle sodium channels contain an alpha subunit and a smaller beta subunit. Interacts with the PDZ domain of the syntrophin SNTA1, SNTB1 and SNTB2 (By similarity). {ECO	0000250}. 
# TCDB	1.A.1.10	the voltage-gated ion channel (vic) superfamily
# UCSC	uc002jds	human
# WEB RESOURCE	SCN4A_HUMAN	Name=Wikipedia; Note=SCN4A entry; URL="https //en.wikipedia.org/wiki/SCN4A";
# eggNOG	COG1226	LUCA
# eggNOG	ENOG410INF8	Eukaryota
BLAST	swissprot:SCN4A_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SCN4A_HUMAN
BioCyc	ZFISH:ENSG00000007314-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000007314-MONOMER
COXPRESdb	6329	http://coxpresdb.jp/data/gene/6329.shtml
CleanEx	HS_SCN4A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SCN4A
DOI	10.1001/archneur.56.6.692	http://dx.doi.org/10.1001/archneur.56.6.692
DOI	10.1002/ajmg.a.32141	http://dx.doi.org/10.1002/ajmg.a.32141
DOI	10.1002/ana.1144	http://dx.doi.org/10.1002/ana.1144
DOI	10.1002/ana.20905	http://dx.doi.org/10.1002/ana.20905
DOI	10.1002/ana.24389	http://dx.doi.org/10.1002/ana.24389
DOI	10.1002/ana.410310203	http://dx.doi.org/10.1002/ana.410310203
DOI	10.1002/ana.410330312	http://dx.doi.org/10.1002/ana.410330312
DOI	10.1002/ana.410370320	http://dx.doi.org/10.1002/ana.410370320
DOI	10.1002/ana.410420219	http://dx.doi.org/10.1002/ana.410420219
DOI	10.1002/ana.410420520	http://dx.doi.org/10.1002/ana.410420520
DOI	10.1002/mus.20080	http://dx.doi.org/10.1002/mus.20080
DOI	10.1002/mus.20733	http://dx.doi.org/10.1002/mus.20733
DOI	10.1002/mus.21155	http://dx.doi.org/10.1002/mus.21155
DOI	10.1007/s10571-007-9231-4	http://dx.doi.org/10.1007/s10571-007-9231-4
DOI	10.1016/0006-291X(92)91802-W	http://dx.doi.org/10.1016/0006-291X(92)91802-W
DOI	10.1016/0092-8674(91)90374-8	http://dx.doi.org/10.1016/0092-8674(91)90374-8
DOI	10.1016/0092-8674(92)90151-2	http://dx.doi.org/10.1016/0092-8674(92)90151-2
DOI	10.1016/0896-6273(92)90203-P	http://dx.doi.org/10.1016/0896-6273(92)90203-P
DOI	10.1016/S0014-5793(99)00338-5	http://dx.doi.org/10.1016/S0014-5793(99)00338-5
DOI	10.1016/j.bbrc.2006.07.101	http://dx.doi.org/10.1016/j.bbrc.2006.07.101
DOI	10.1016/j.nmd.2008.01.007	http://dx.doi.org/10.1016/j.nmd.2008.01.007
DOI	10.1016/j.nmd.2015.01.006	http://dx.doi.org/10.1016/j.nmd.2015.01.006
DOI	10.1038/354387a0	http://dx.doi.org/10.1038/354387a0
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1038/nature19057	http://dx.doi.org/10.1038/nature19057
DOI	10.1038/ng1092-148	http://dx.doi.org/10.1038/ng1092-148
DOI	10.1073/pnas.1230273100	http://dx.doi.org/10.1073/pnas.1230273100
DOI	10.1073/pnas.97.17.9549	http://dx.doi.org/10.1073/pnas.97.17.9549
DOI	10.1093/brain/awu015	http://dx.doi.org/10.1093/brain/awu015
DOI	10.1093/brain/awv352	http://dx.doi.org/10.1093/brain/awv352
DOI	10.1093/hmg/1.7.521	http://dx.doi.org/10.1093/hmg/1.7.521
DOI	10.1093/hmg/2.9.1349	http://dx.doi.org/10.1093/hmg/2.9.1349
DOI	10.1111/j.1440-1789.2008.00985.x	http://dx.doi.org/10.1111/j.1440-1789.2008.00985.x
DOI	10.1113/jphysiol.1993.sp019843	http://dx.doi.org/10.1113/jphysiol.1993.sp019843
DOI	10.1113/jphysiol.2004.081018	http://dx.doi.org/10.1113/jphysiol.2004.081018
DOI	10.1136/jnnp.2009.177451	http://dx.doi.org/10.1136/jnnp.2009.177451
DOI	10.1136/jnnp.68.4.504	http://dx.doi.org/10.1136/jnnp.68.4.504
DOI	10.1212/01.WNL.0000145768.09934.EC	http://dx.doi.org/10.1212/01.WNL.0000145768.09934.EC
DOI	10.1212/01.wnl.0000223838.88872.da	http://dx.doi.org/10.1212/01.wnl.0000223838.88872.da
DOI	10.1212/01.wnl.0000265397.70057.d8	http://dx.doi.org/10.1212/01.wnl.0000265397.70057.d8
DOI	10.1212/01.wnl.0000287069.21162.94	http://dx.doi.org/10.1212/01.wnl.0000287069.21162.94
DOI	10.1212/01.wnl.0000290831.08585.2c	http://dx.doi.org/10.1212/01.wnl.0000290831.08585.2c
DOI	10.1212/01.wnl.0000335168.86248.55	http://dx.doi.org/10.1212/01.wnl.0000335168.86248.55
DOI	10.1212/01.wnl.0000342387.65477.46	http://dx.doi.org/10.1212/01.wnl.0000342387.65477.46
DOI	10.1212/WNL.0000000000002264	http://dx.doi.org/10.1212/WNL.0000000000002264
DOI	10.1212/WNL.44.8.1500	http://dx.doi.org/10.1212/WNL.44.8.1500
DOI	10.1212/WNL.53.9.1932	http://dx.doi.org/10.1212/WNL.53.9.1932
DOI	10.1212/WNL.54.11.2179	http://dx.doi.org/10.1212/WNL.54.11.2179
DOI	10.1212/WNL.57.7.1323	http://dx.doi.org/10.1212/WNL.57.7.1323
DOI	10.3346/jkms.2007.22.6.946	http://dx.doi.org/10.3346/jkms.2007.22.6.946
DOI	10.3988/jcn.2009.5.4.186	http://dx.doi.org/10.3988/jcn.2009.5.4.186
DOI	10.4161/chan.2.1.6051	http://dx.doi.org/10.4161/chan.2.1.6051
DrugBank	DB00313	http://www.drugbank.ca/drugs/DB00313
DrugBank	DB00586	http://www.drugbank.ca/drugs/DB00586
DrugBank	DB00818	http://www.drugbank.ca/drugs/DB00818
DrugBank	DB00909	http://www.drugbank.ca/drugs/DB00909
DrugBank	DB01195	http://www.drugbank.ca/drugs/DB01195
EMBL	AC127029	http://www.ebi.ac.uk/ena/data/view/AC127029
EMBL	AY212253	http://www.ebi.ac.uk/ena/data/view/AY212253
EMBL	L01962	http://www.ebi.ac.uk/ena/data/view/L01962
EMBL	L01963	http://www.ebi.ac.uk/ena/data/view/L01963
EMBL	L01964	http://www.ebi.ac.uk/ena/data/view/L01964
EMBL	L01965	http://www.ebi.ac.uk/ena/data/view/L01965
EMBL	L01966	http://www.ebi.ac.uk/ena/data/view/L01966
EMBL	L01967	http://www.ebi.ac.uk/ena/data/view/L01967
EMBL	L01968	http://www.ebi.ac.uk/ena/data/view/L01968
EMBL	L01969	http://www.ebi.ac.uk/ena/data/view/L01969
EMBL	L01970	http://www.ebi.ac.uk/ena/data/view/L01970
EMBL	L01971	http://www.ebi.ac.uk/ena/data/view/L01971
EMBL	L01972	http://www.ebi.ac.uk/ena/data/view/L01972
EMBL	L01973	http://www.ebi.ac.uk/ena/data/view/L01973
EMBL	L01974	http://www.ebi.ac.uk/ena/data/view/L01974
EMBL	L01975	http://www.ebi.ac.uk/ena/data/view/L01975
EMBL	L01976	http://www.ebi.ac.uk/ena/data/view/L01976
EMBL	L01977	http://www.ebi.ac.uk/ena/data/view/L01977
EMBL	L01978	http://www.ebi.ac.uk/ena/data/view/L01978
EMBL	L01979	http://www.ebi.ac.uk/ena/data/view/L01979
EMBL	L01980	http://www.ebi.ac.uk/ena/data/view/L01980
EMBL	L01981	http://www.ebi.ac.uk/ena/data/view/L01981
EMBL	L01982	http://www.ebi.ac.uk/ena/data/view/L01982
EMBL	L01983	http://www.ebi.ac.uk/ena/data/view/L01983
EMBL	L04216	http://www.ebi.ac.uk/ena/data/view/L04216
EMBL	L04217	http://www.ebi.ac.uk/ena/data/view/L04217
EMBL	L04218	http://www.ebi.ac.uk/ena/data/view/L04218
EMBL	L04219	http://www.ebi.ac.uk/ena/data/view/L04219
EMBL	L04220	http://www.ebi.ac.uk/ena/data/view/L04220
EMBL	L04221	http://www.ebi.ac.uk/ena/data/view/L04221
EMBL	L04222	http://www.ebi.ac.uk/ena/data/view/L04222
EMBL	L04223	http://www.ebi.ac.uk/ena/data/view/L04223
EMBL	L04224	http://www.ebi.ac.uk/ena/data/view/L04224
EMBL	L04225	http://www.ebi.ac.uk/ena/data/view/L04225
EMBL	L04226	http://www.ebi.ac.uk/ena/data/view/L04226
EMBL	L04227	http://www.ebi.ac.uk/ena/data/view/L04227
EMBL	L04228	http://www.ebi.ac.uk/ena/data/view/L04228
EMBL	L04229	http://www.ebi.ac.uk/ena/data/view/L04229
EMBL	L04230	http://www.ebi.ac.uk/ena/data/view/L04230
EMBL	L04231	http://www.ebi.ac.uk/ena/data/view/L04231
EMBL	L04232	http://www.ebi.ac.uk/ena/data/view/L04232
EMBL	L04233	http://www.ebi.ac.uk/ena/data/view/L04233
EMBL	L04234	http://www.ebi.ac.uk/ena/data/view/L04234
EMBL	L04235	http://www.ebi.ac.uk/ena/data/view/L04235
EMBL	L04236	http://www.ebi.ac.uk/ena/data/view/L04236
EMBL	M81758	http://www.ebi.ac.uk/ena/data/view/M81758
EMBL	S82622	http://www.ebi.ac.uk/ena/data/view/S82622
Ensembl	ENST00000435607	http://www.ensembl.org/id/ENST00000435607
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0001518	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001518
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005248	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005248
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0006936	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006936
GO_process	GO:0019228	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019228
GO_process	GO:0086010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086010
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	SCN4A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SCN4A
GeneID	6329	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6329
GeneTree	ENSGT00830000128242	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00830000128242
H-InvDB	HIX0039131	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0039131
HGNC	HGNC:10591	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10591
HOGENOM	HOG000231755	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231755&db=HOGENOM6
HOVERGEN	HBG053100	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053100&db=HOVERGEN
HPA	HPA053992	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA053992
InParanoid	P35499	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P35499
InterPro	IPR000048	http://www.ebi.ac.uk/interpro/entry/IPR000048
InterPro	IPR001696	http://www.ebi.ac.uk/interpro/entry/IPR001696
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR008052	http://www.ebi.ac.uk/interpro/entry/IPR008052
InterPro	IPR010526	http://www.ebi.ac.uk/interpro/entry/IPR010526
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028826	http://www.ebi.ac.uk/interpro/entry/IPR028826
Jabion	6329	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6329
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00215	http://www.genome.jp/dbget-bin/www_bget?H00215
KEGG_Disease	H00743	http://www.genome.jp/dbget-bin/www_bget?H00743
KEGG_Disease	H00744	http://www.genome.jp/dbget-bin/www_bget?H00744
KEGG_Disease	H00745	http://www.genome.jp/dbget-bin/www_bget?H00745
KEGG_Disease	H00746	http://www.genome.jp/dbget-bin/www_bget?H00746
KEGG_Disease	H00770	http://www.genome.jp/dbget-bin/www_bget?H00770
KEGG_Gene	hsa:6329	http://www.genome.jp/dbget-bin/www_bget?hsa:6329
KEGG_Orthology	KO:K04837	http://www.genome.jp/dbget-bin/www_bget?KO:K04837
MIM	168300	http://www.ncbi.nlm.nih.gov/omim/168300
MIM	170500	http://www.ncbi.nlm.nih.gov/omim/170500
MIM	603967	http://www.ncbi.nlm.nih.gov/omim/603967
MIM	608390	http://www.ncbi.nlm.nih.gov/omim/608390
MIM	613345	http://www.ncbi.nlm.nih.gov/omim/613345
MIM	614198	http://www.ncbi.nlm.nih.gov/omim/614198
Orphanet	681	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=681
Orphanet	682	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=682
Orphanet	684	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=684
Orphanet	98913	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98913
Orphanet	99734	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=99734
Orphanet	99735	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=99735
Orphanet	99736	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=99736
OrthoDB	EOG091G00FK	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00FK
PANTHER	PTHR10037:SF223	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10037:SF223
PRINTS	PR00170	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00170
PRINTS	PR01665	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01665
PROSITE	PS50096	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50096
PSORT	swissprot:SCN4A_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SCN4A_HUMAN
PSORT-B	swissprot:SCN4A_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SCN4A_HUMAN
PSORT2	swissprot:SCN4A_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SCN4A_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF06512	http://pfam.xfam.org/family/PF06512
PharmGKB	PA35006	http://www.pharmgkb.org/do/serve?objId=PA35006&objCls=Gene
Phobius	swissprot:SCN4A_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SCN4A_HUMAN
PhylomeDB	P35499	http://phylomedb.org/?seqid=P35499
ProteinModelPortal	P35499	http://www.proteinmodelportal.org/query/uniprot/P35499
PubMed	10218481	http://www.ncbi.nlm.nih.gov/pubmed/10218481
PubMed	10369308	http://www.ncbi.nlm.nih.gov/pubmed/10369308
PubMed	10599760	http://www.ncbi.nlm.nih.gov/pubmed/10599760
PubMed	10727489	http://www.ncbi.nlm.nih.gov/pubmed/10727489
PubMed	10851391	http://www.ncbi.nlm.nih.gov/pubmed/10851391
PubMed	10944223	http://www.ncbi.nlm.nih.gov/pubmed/10944223
PubMed	11558801	http://www.ncbi.nlm.nih.gov/pubmed/11558801
PubMed	11591859	http://www.ncbi.nlm.nih.gov/pubmed/11591859
PubMed	12766226	http://www.ncbi.nlm.nih.gov/pubmed/12766226
PubMed	1310396	http://www.ncbi.nlm.nih.gov/pubmed/1310396
PubMed	1310898	http://www.ncbi.nlm.nih.gov/pubmed/1310898
PubMed	1315496	http://www.ncbi.nlm.nih.gov/pubmed/1315496
PubMed	1316765	http://www.ncbi.nlm.nih.gov/pubmed/1316765
PubMed	1338909	http://www.ncbi.nlm.nih.gov/pubmed/1338909
PubMed	1339144	http://www.ncbi.nlm.nih.gov/pubmed/1339144
PubMed	15318338	http://www.ncbi.nlm.nih.gov/pubmed/15318338
PubMed	15596759	http://www.ncbi.nlm.nih.gov/pubmed/15596759
PubMed	15790667	http://www.ncbi.nlm.nih.gov/pubmed/15790667
PubMed	1659668	http://www.ncbi.nlm.nih.gov/pubmed/1659668
PubMed	1659948	http://www.ncbi.nlm.nih.gov/pubmed/1659948
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	16786525	http://www.ncbi.nlm.nih.gov/pubmed/16786525
PubMed	16832098	http://www.ncbi.nlm.nih.gov/pubmed/16832098
PubMed	16890191	http://www.ncbi.nlm.nih.gov/pubmed/16890191
PubMed	17212350	http://www.ncbi.nlm.nih.gov/pubmed/17212350
PubMed	17898326	http://www.ncbi.nlm.nih.gov/pubmed/17898326
PubMed	17998485	http://www.ncbi.nlm.nih.gov/pubmed/17998485
PubMed	18046642	http://www.ncbi.nlm.nih.gov/pubmed/18046642
PubMed	18162704	http://www.ncbi.nlm.nih.gov/pubmed/18162704
PubMed	18166706	http://www.ncbi.nlm.nih.gov/pubmed/18166706
PubMed	18203179	http://www.ncbi.nlm.nih.gov/pubmed/18203179
PubMed	18337100	http://www.ncbi.nlm.nih.gov/pubmed/18337100
PubMed	18690054	http://www.ncbi.nlm.nih.gov/pubmed/18690054
PubMed	19015483	http://www.ncbi.nlm.nih.gov/pubmed/19015483
PubMed	19077043	http://www.ncbi.nlm.nih.gov/pubmed/19077043
PubMed	19118277	http://www.ncbi.nlm.nih.gov/pubmed/19118277
PubMed	19347921	http://www.ncbi.nlm.nih.gov/pubmed/19347921
PubMed	20076800	http://www.ncbi.nlm.nih.gov/pubmed/20076800
PubMed	20522878	http://www.ncbi.nlm.nih.gov/pubmed/20522878
PubMed	21043388	http://www.ncbi.nlm.nih.gov/pubmed/21043388
PubMed	24549961	http://www.ncbi.nlm.nih.gov/pubmed/24549961
PubMed	25660391	http://www.ncbi.nlm.nih.gov/pubmed/25660391
PubMed	25707578	http://www.ncbi.nlm.nih.gov/pubmed/25707578
PubMed	26659129	http://www.ncbi.nlm.nih.gov/pubmed/26659129
PubMed	26700687	http://www.ncbi.nlm.nih.gov/pubmed/26700687
PubMed	27535533	http://www.ncbi.nlm.nih.gov/pubmed/27535533
PubMed	7695243	http://www.ncbi.nlm.nih.gov/pubmed/7695243
PubMed	8058156	http://www.ncbi.nlm.nih.gov/pubmed/8058156
PubMed	8242056	http://www.ncbi.nlm.nih.gov/pubmed/8242056
PubMed	8308722	http://www.ncbi.nlm.nih.gov/pubmed/8308722
PubMed	8388676	http://www.ncbi.nlm.nih.gov/pubmed/8388676
PubMed	8580427	http://www.ncbi.nlm.nih.gov/pubmed/8580427
PubMed	9266738	http://www.ncbi.nlm.nih.gov/pubmed/9266738
PubMed	9392583	http://www.ncbi.nlm.nih.gov/pubmed/9392583
Reactome	R-HSA-445095	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-445095
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
RefSeq	NP_000325	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000325
STRING	9606.ENSP00000396320	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000396320&targetmode=cogs
TCDB	1.A.1.10	http://www.tcdb.org/search/result.php?tc=1.A.1.10
UCSC	uc002jds	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002jds&org=rat
UniGene	Hs.46038	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.46038
UniProtKB	SCN4A_HUMAN	http://www.uniprot.org/uniprot/SCN4A_HUMAN
UniProtKB-AC	P35499	http://www.uniprot.org/uniprot/P35499
charge	swissprot:SCN4A_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SCN4A_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	ENOG410INF8	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410INF8
epestfind	swissprot:SCN4A_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SCN4A_HUMAN
garnier	swissprot:SCN4A_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SCN4A_HUMAN
helixturnhelix	swissprot:SCN4A_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SCN4A_HUMAN
hmoment	swissprot:SCN4A_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SCN4A_HUMAN
iep	swissprot:SCN4A_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SCN4A_HUMAN
inforesidue	swissprot:SCN4A_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SCN4A_HUMAN
neXtProt	NX_P35499	http://www.nextprot.org/db/entry/NX_P35499
octanol	swissprot:SCN4A_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SCN4A_HUMAN
pepcoil	swissprot:SCN4A_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SCN4A_HUMAN
pepdigest	swissprot:SCN4A_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SCN4A_HUMAN
pepinfo	swissprot:SCN4A_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SCN4A_HUMAN
pepnet	swissprot:SCN4A_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SCN4A_HUMAN
pepstats	swissprot:SCN4A_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SCN4A_HUMAN
pepwheel	swissprot:SCN4A_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SCN4A_HUMAN
pepwindow	swissprot:SCN4A_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SCN4A_HUMAN
sigcleave	swissprot:SCN4A_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SCN4A_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S35A3_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9Y2D2-1; Sequence=Displayed; Name=2; IsoId=Q9Y2D2-2; Sequence=VSP_012786; Note=No experimental confirmation available.; Name=3; IsoId=Q9Y2D2-3; Sequence=VSP_054232, VSP_054233; Note=No experimental confirmation available.; 
# AltName	S35A3_HUMAN	Golgi UDP-GlcNAc transporter
# AltName	S35A3_HUMAN	Solute carrier family 35 member A3
# BioGrid	117010	2
# CCDS	CCDS60204	-. [Q9Y2D2-2]
# CCDS	CCDS60205	-. [Q9Y2D2-3]
# CCDS	CCDS762	-. [Q9Y2D2-1]
# ChiTaRS	SLC35A3	human
# DISEASE	S35A3_HUMAN	Arthrogryposis, mental retardation, and seizures (AMRS) [MIM 615553]  A disease characterized by arthrogryposis, mental retardation, autism spectrum disorder, and epilepsy. Additional features include limb malformations, distal joint involvement, microcephaly, retromicrognathia, and general muscle hypotonia. {ECO 0000269|PubMed 24031089}. Note=The disease is caused by mutations affecting the gene represented in this entry. In Golgi vesicles isolated from patient fibroblasts the transport of the respective nucleotide sugar is significantly reduced causing a massive decrease in the content of cell surface expressed highly branched N-glycans and a concomitant sharp increase of lower branched glycoforms. 
# Ensembl	ENST00000370153	ENSP00000359172; ENSG00000117620. [Q9Y2D2-2]
# Ensembl	ENST00000427993	ENSP00000414947; ENSG00000117620. [Q9Y2D2-1]
# Ensembl	ENST00000465289	ENSP00000418527; ENSG00000117620. [Q9Y2D2-3]
# Ensembl	ENST00000533028	ENSP00000433849; ENSG00000117620. [Q9Y2D2-1]
# ExpressionAtlas	Q9Y2D2	baseline and differential
# FUNCTION	S35A3_HUMAN	Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter in the Golgi apparatus. May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransferases that generate branching of diantennary oligosaccharides. {ECO 0000269|PubMed 10393322}. 
# GO_component	GO:0000139	Golgi membrane; TAS:Reactome.
# GO_component	GO:0005794	Golgi apparatus; TAS:ProtInc.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005462	UDP-N-acetylglucosamine transmembrane transporter activity; TAS:Reactome.
# GO_function	S35A3_HUMAN	GO 0005351 sugar proton symporter activity; IEA InterPro.
# GO_process	GO:0006047	UDP-N-acetylglucosamine metabolic process; TAS:ProtInc.
# GO_process	GO:0015788	UDP-N-acetylglucosamine transport; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# Genevisible	Q9Y2D2	HS
# HGNC	HGNC:11023	SLC35A3
# INTERACTION	S35A3_HUMAN	P78381-1 SLC35A2; NbExp=3; IntAct=EBI-3917581, EBI-8101118; P78381-2 SLC35A2; NbExp=2; IntAct=EBI-3917581, EBI-8101093; 
# IntAct	Q9Y2D2	3
# InterPro	IPR007271	Nuc_sug_transpt
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H01392	[Skeletal dysplasia; Epilepsy] Arthrogryposis, mental retardation, and seizures (AMRS)
# MIM	605632	gene
# MIM	615553	phenotype
# Organism	S35A3_HUMAN	Homo sapiens (Human)
# Orphanet	370943	Autism spectrum disorder-epilepsy-arthrogryposis syndrome
# PANTHER	PTHR10231	PTHR10231
# PIRSF	PIRSF005799	UDP-gal_transpt
# Pfam	PF04142	Nuc_sug_transp
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-727802	Transport of nucleotide sugars
# RecName	S35A3_HUMAN	UDP-N-acetylglucosamine transporter
# RefSeq	NP_001258613	NM_001271684.1. [Q9Y2D2-3]
# RefSeq	NP_001258614	NM_001271685.1. [Q9Y2D2-2]
# RefSeq	NP_036375	NM_012243.2. [Q9Y2D2-1]
# RefSeq	XP_005270748	XM_005270691.4. [Q9Y2D2-1]
# RefSeq	XP_011539438	XM_011541136.2. [Q9Y2D2-1]
# SIMILARITY	Belongs to the nucleotide-sugar transporter family. SLC35A subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	S35A3_HUMAN	Golgi apparatus membrane {ECO 0000269|PubMed 10393322}; Multi-pass membrane protein {ECO 0000269|PubMed 10393322}. 
# SUBUNIT	Interacts with SLC35A2. {ECO:0000269|PubMed	23089177}. 
# TCDB	2.A.7.12	the drug/metabolite transporter (dmt) superfamily
# TopDownProteomics	Q9Y2D2-1	-. [Q9Y2D2-1]
# UCSC	uc001dsp	human. [Q9Y2D2-1]
# eggNOG	COG0697	LUCA
# eggNOG	KOG2234	Eukaryota
BLAST	swissprot:S35A3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S35A3_HUMAN
BioCyc	ZFISH:ENSG00000117620-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000117620-MONOMER
COXPRESdb	23443	http://coxpresdb.jp/data/gene/23443.shtml
CleanEx	HS_SLC35A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC35A3
DOI	10.1016/j.febslet.2012.10.016	http://dx.doi.org/10.1016/j.febslet.2012.10.016
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/oxfordjournals.jbchem.a022437	http://dx.doi.org/10.1093/oxfordjournals.jbchem.a022437
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1136/jmedgenet-2013-101753	http://dx.doi.org/10.1136/jmedgenet-2013-101753
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AB021981	http://www.ebi.ac.uk/ena/data/view/AB021981
EMBL	AC118553	http://www.ebi.ac.uk/ena/data/view/AC118553
EMBL	AK290573	http://www.ebi.ac.uk/ena/data/view/AK290573
EMBL	BC005136	http://www.ebi.ac.uk/ena/data/view/BC005136
EMBL	CH471097	http://www.ebi.ac.uk/ena/data/view/CH471097
EMBL	CH471097	http://www.ebi.ac.uk/ena/data/view/CH471097
EMBL	CH471097	http://www.ebi.ac.uk/ena/data/view/CH471097
EMBL	CR749816	http://www.ebi.ac.uk/ena/data/view/CR749816
Ensembl	ENST00000370153	http://www.ensembl.org/id/ENST00000370153
Ensembl	ENST00000427993	http://www.ensembl.org/id/ENST00000427993
Ensembl	ENST00000465289	http://www.ensembl.org/id/ENST00000465289
Ensembl	ENST00000533028	http://www.ensembl.org/id/ENST00000533028
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005351	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005351
GO_function	GO:0005462	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005462
GO_process	GO:0006047	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006047
GO_process	GO:0015788	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015788
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GeneCards	SLC35A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC35A3
GeneID	23443	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23443
GeneTree	ENSGT00550000074563	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074563
HGNC	HGNC:11023	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11023
HOGENOM	HOG000216649	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000216649&db=HOGENOM6
HOVERGEN	HBG054025	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054025&db=HOVERGEN
HPA	HPA015253	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA015253
InParanoid	Q9Y2D2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y2D2
IntAct	Q9Y2D2	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9Y2D2*
InterPro	IPR007271	http://www.ebi.ac.uk/interpro/entry/IPR007271
Jabion	23443	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=23443
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H01392	http://www.genome.jp/dbget-bin/www_bget?H01392
KEGG_Gene	hsa:23443	http://www.genome.jp/dbget-bin/www_bget?hsa:23443
KEGG_Orthology	KO:K15272	http://www.genome.jp/dbget-bin/www_bget?KO:K15272
MIM	605632	http://www.ncbi.nlm.nih.gov/omim/605632
MIM	615553	http://www.ncbi.nlm.nih.gov/omim/615553
MINT	MINT-4781806	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4781806
OMA	NWAVWST	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NWAVWST
Orphanet	370943	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=370943
OrthoDB	EOG091G0CHS	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0CHS
PANTHER	PTHR10231	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10231
PSORT	swissprot:S35A3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S35A3_HUMAN
PSORT-B	swissprot:S35A3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S35A3_HUMAN
PSORT2	swissprot:S35A3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S35A3_HUMAN
Pfam	PF04142	http://pfam.xfam.org/family/PF04142
PharmGKB	PA35891	http://www.pharmgkb.org/do/serve?objId=PA35891&objCls=Gene
Phobius	swissprot:S35A3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S35A3_HUMAN
PhylomeDB	Q9Y2D2	http://phylomedb.org/?seqid=Q9Y2D2
ProteinModelPortal	Q9Y2D2	http://www.proteinmodelportal.org/query/uniprot/Q9Y2D2
PubMed	10393322	http://www.ncbi.nlm.nih.gov/pubmed/10393322
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	23089177	http://www.ncbi.nlm.nih.gov/pubmed/23089177
PubMed	24031089	http://www.ncbi.nlm.nih.gov/pubmed/24031089
Reactome	R-HSA-727802	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-727802
RefSeq	NP_001258613	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001258613
RefSeq	NP_001258614	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001258614
RefSeq	NP_036375	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_036375
RefSeq	XP_005270748	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005270748
RefSeq	XP_011539438	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011539438
STRING	9606.ENSP00000359174	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000359174&targetmode=cogs
TCDB	2.A.7.12	http://www.tcdb.org/search/result.php?tc=2.A.7.12
UCSC	uc001dsp	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001dsp&org=rat
UniGene	Hs.448979	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.448979
UniGene	Hs.534953	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.534953
UniProtKB	S35A3_HUMAN	http://www.uniprot.org/uniprot/S35A3_HUMAN
UniProtKB-AC	Q9Y2D2	http://www.uniprot.org/uniprot/Q9Y2D2
charge	swissprot:S35A3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S35A3_HUMAN
eggNOG	COG0697	http://eggnogapi.embl.de/nog_data/html/tree/COG0697
eggNOG	KOG2234	http://eggnogapi.embl.de/nog_data/html/tree/KOG2234
epestfind	swissprot:S35A3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S35A3_HUMAN
garnier	swissprot:S35A3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S35A3_HUMAN
helixturnhelix	swissprot:S35A3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S35A3_HUMAN
hmoment	swissprot:S35A3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S35A3_HUMAN
iep	swissprot:S35A3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S35A3_HUMAN
inforesidue	swissprot:S35A3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S35A3_HUMAN
neXtProt	NX_Q9Y2D2	http://www.nextprot.org/db/entry/NX_Q9Y2D2
octanol	swissprot:S35A3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S35A3_HUMAN
pepcoil	swissprot:S35A3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S35A3_HUMAN
pepdigest	swissprot:S35A3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S35A3_HUMAN
pepinfo	swissprot:S35A3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S35A3_HUMAN
pepnet	swissprot:S35A3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S35A3_HUMAN
pepstats	swissprot:S35A3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S35A3_HUMAN
pepwheel	swissprot:S35A3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S35A3_HUMAN
pepwindow	swissprot:S35A3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S35A3_HUMAN
sigcleave	swissprot:S35A3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S35A3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S38A7_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NVC3-1; Sequence=Displayed; Name=2; IsoId=Q9NVC3-2; Sequence=VSP_031511; Note=No experimental confirmation available.; 
# AltName	S38A7_HUMAN	Solute carrier family 38 member 7
# BioGrid	120531	11
# CCDS	CCDS10800	-. [Q9NVC3-1]
# ChiTaRS	SLC38A7	human
# Ensembl	ENST00000219320	ENSP00000219320; ENSG00000103042. [Q9NVC3-1]
# Ensembl	ENST00000570101	ENSP00000454646; ENSG00000103042. [Q9NVC3-1]
# ExpressionAtlas	Q9NVC3	baseline and differential
# FUNCTION	S38A7_HUMAN	Mediates sodium-dependent transport of amino acids, preferentially L-glutamine. {ECO 0000250}. 
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0030424	axon; ISS:UniProtKB.
# GO_component	GO:0043025	neuronal cell body; ISS:UniProtKB.
# GO_function	GO:0005290	L-histidine transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0005313	L-glutamate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015179	L-amino acid transmembrane transporter activity; ISS:UniProtKB.
# GO_function	GO:0015180	L-alanine transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015182	L-asparagine transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015183	L-aspartate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015186	L-glutamine transmembrane transporter activity; ISS:UniProtKB.
# GO_function	GO:0015190	L-leucine transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015191	L-methionine transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015194	L-serine transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0006814	sodium ion transport; ISS:UniProtKB.
# GO_process	GO:0006867	asparagine transport; IBA:GO_Central.
# GO_process	GO:0015808	L-alanine transport; IBA:GO_Central.
# GO_process	GO:0015810	aspartate transport; IBA:GO_Central.
# GO_process	GO:0015825	L-serine transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q9NVC3	HS
# HGNC	HGNC:25582	SLC38A7
# INTERACTION	S38A7_HUMAN	Q99942 RNF5; NbExp=3; IntAct=EBI-10314552, EBI-348482; 
# IntAct	Q9NVC3	3
# InterPro	IPR013057	AA_transpt_TM
# KEGG_Brite	ko02001	Solute carrier family
# MIM	614236	gene
# Organism	S38A7_HUMAN	Homo sapiens (Human)
# Pfam	PF01490	Aa_trans
# Proteomes	UP000005640	Chromosome 16
# RecName	S38A7_HUMAN	Putative sodium-coupled neutral amino acid transporter 7
# RefSeq	NP_060701	NM_018231.2. [Q9NVC3-1]
# RefSeq	XP_016878882	XM_017023393.1. [Q9NVC3-1]
# RefSeq	XP_016878886	XM_017023397.1. [Q9NVC3-2]
# SIMILARITY	Belongs to the amino acid/polyamine transporter 2 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S38A7_HUMAN	Membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Note=In neurons, located in soma and axons. {ECO 0000250}. 
# TCDB	2.A.18.6.13	the amino acid/auxin permease (aaap) family
# UCSC	uc002eod	human. [Q9NVC3-1]
# eggNOG	COG0814	LUCA
# eggNOG	KOG1305	Eukaryota
BLAST	swissprot:S38A7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S38A7_HUMAN
BioCyc	ZFISH:ENSG00000103042-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000103042-MONOMER
COXPRESdb	55238	http://coxpresdb.jp/data/gene/55238.shtml
CleanEx	HS_SLC38A7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC38A7
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AK001677	http://www.ebi.ac.uk/ena/data/view/AK001677
EMBL	AK022786	http://www.ebi.ac.uk/ena/data/view/AK022786
EMBL	AK222932	http://www.ebi.ac.uk/ena/data/view/AK222932
EMBL	BC001961	http://www.ebi.ac.uk/ena/data/view/BC001961
EMBL	CH471092	http://www.ebi.ac.uk/ena/data/view/CH471092
EMBL	CR457236	http://www.ebi.ac.uk/ena/data/view/CR457236
Ensembl	ENST00000219320	http://www.ensembl.org/id/ENST00000219320
Ensembl	ENST00000570101	http://www.ensembl.org/id/ENST00000570101
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030424	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030424
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_function	GO:0005290	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005290
GO_function	GO:0005313	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005313
GO_function	GO:0015179	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015179
GO_function	GO:0015180	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015180
GO_function	GO:0015182	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015182
GO_function	GO:0015183	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015183
GO_function	GO:0015186	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015186
GO_function	GO:0015190	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015190
GO_function	GO:0015191	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015191
GO_function	GO:0015194	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015194
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0006867	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006867
GO_process	GO:0015808	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015808
GO_process	GO:0015810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015810
GO_process	GO:0015825	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015825
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC38A7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC38A7
GeneID	55238	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55238
GeneTree	ENSGT00710000106751	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00710000106751
HGNC	HGNC:25582	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:25582
HOGENOM	HOG000008036	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000008036&db=HOGENOM6
HOVERGEN	HBG055999	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG055999&db=HOVERGEN
HPA	HPA041777	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA041777
InParanoid	Q9NVC3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NVC3
IntAct	Q9NVC3	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NVC3*
InterPro	IPR013057	http://www.ebi.ac.uk/interpro/entry/IPR013057
Jabion	55238	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55238
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:55238	http://www.genome.jp/dbget-bin/www_bget?hsa:55238
KEGG_Orthology	KO:K14994	http://www.genome.jp/dbget-bin/www_bget?KO:K14994
MIM	614236	http://www.ncbi.nlm.nih.gov/omim/614236
MINT	MINT-4650882	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4650882
OMA	SWVAVFN	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SWVAVFN
OrthoDB	EOG091G08A4	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08A4
PSORT	swissprot:S38A7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S38A7_HUMAN
PSORT-B	swissprot:S38A7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S38A7_HUMAN
PSORT2	swissprot:S38A7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S38A7_HUMAN
Pfam	PF01490	http://pfam.xfam.org/family/PF01490
PharmGKB	PA162403772	http://www.pharmgkb.org/do/serve?objId=PA162403772&objCls=Gene
Phobius	swissprot:S38A7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S38A7_HUMAN
PhylomeDB	Q9NVC3	http://phylomedb.org/?seqid=Q9NVC3
ProteinModelPortal	Q9NVC3	http://www.proteinmodelportal.org/query/uniprot/Q9NVC3
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
RefSeq	NP_060701	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060701
RefSeq	XP_016878882	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016878882
RefSeq	XP_016878886	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016878886
STRING	9606.ENSP00000219320	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000219320&targetmode=cogs
TCDB	2.A.18.6.13	http://www.tcdb.org/search/result.php?tc=2.A.18.6.13
UCSC	uc002eod	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002eod&org=rat
UniGene	Hs.10499	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.10499
UniGene	Hs.593499	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.593499
UniProtKB	S38A7_HUMAN	http://www.uniprot.org/uniprot/S38A7_HUMAN
UniProtKB-AC	Q9NVC3	http://www.uniprot.org/uniprot/Q9NVC3
charge	swissprot:S38A7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S38A7_HUMAN
eggNOG	COG0814	http://eggnogapi.embl.de/nog_data/html/tree/COG0814
eggNOG	KOG1305	http://eggnogapi.embl.de/nog_data/html/tree/KOG1305
epestfind	swissprot:S38A7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S38A7_HUMAN
garnier	swissprot:S38A7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S38A7_HUMAN
helixturnhelix	swissprot:S38A7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S38A7_HUMAN
hmoment	swissprot:S38A7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S38A7_HUMAN
iep	swissprot:S38A7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S38A7_HUMAN
inforesidue	swissprot:S38A7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S38A7_HUMAN
neXtProt	NX_Q9NVC3	http://www.nextprot.org/db/entry/NX_Q9NVC3
octanol	swissprot:S38A7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S38A7_HUMAN
pepcoil	swissprot:S38A7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S38A7_HUMAN
pepdigest	swissprot:S38A7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S38A7_HUMAN
pepinfo	swissprot:S38A7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S38A7_HUMAN
pepnet	swissprot:S38A7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S38A7_HUMAN
pepstats	swissprot:S38A7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S38A7_HUMAN
pepwheel	swissprot:S38A7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S38A7_HUMAN
pepwindow	swissprot:S38A7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S38A7_HUMAN
sigcleave	swissprot:S38A7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S38A7_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AT132_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=A; IsoId=Q9NQ11-1; Sequence=Displayed; Name=B; IsoId=Q9NQ11-2; Sequence=VSP_007310, VSP_007311, VSP_007312; Name=3; IsoId=Q9NQ11-3; Sequence=VSP_007310; 
# BioGrid	116973	71
# CATALYTIC ACTIVITY	AT132_HUMAN	ATP + H(2)O = ADP + phosphate. 
# CCDS	CCDS175	-. [Q9NQ11-1]
# CCDS	CCDS44072	-. [Q9NQ11-2]
# CCDS	CCDS44073	-. [Q9NQ11-3]
# ChiTaRS	ATP13A2	human
# DISEASE	AT132_HUMAN	Ceroid lipofuscinosis, neuronal, 12 (CLN12) [MIM 606693]  A form of neuronal ceroid lipofuscinosis characterized by rapidly progressive visual loss due to retinal dystrophy, seizures, cerebellar ataxia, and cerebellar atrophy. Cognitive decline may also occur. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material. {ECO 0000269|PubMed 22388936}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	AT132_HUMAN	Kufor-Rakeb syndrome (KRS) [MIM 606693]  A rare form of autosomal recessive juvenile or early-onset, levodopa-responsive parkinsonism. In addition to typical parkinsonian signs, clinical manifestations of Kufor-Rakeb syndrome include behavioral problems, facial tremor, pyramidal tract dysfunction, supranuclear gaze palsy, and dementia. {ECO 0000269|PubMed 16964263, ECO 0000269|PubMed 17485642, ECO 0000269|PubMed 18413573, ECO 0000269|PubMed 20683840, ECO 0000269|PubMed 20853184, ECO 0000269|PubMed 21542062}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000326735	ENSP00000327214; ENSG00000159363. [Q9NQ11-1]
# Ensembl	ENST00000341676	ENSP00000341115; ENSG00000159363. [Q9NQ11-2]
# Ensembl	ENST00000452699	ENSP00000413307; ENSG00000159363. [Q9NQ11-3]
# ExpressionAtlas	Q9NQ11	baseline and differential
# FUNCTION	AT132_HUMAN	May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity. {ECO 0000269|PubMed 22186024}. 
# GO_component	GO:0005764	lysosome; IDA:UniProtKB.
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005770	late endosome; IDA:ParkinsonsUK-UCL.
# GO_component	GO:0005771	multivesicular body; IDA:ParkinsonsUK-UCL.
# GO_component	GO:0005776	autophagosome; IDA:ParkinsonsUK-UCL.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0012506	vesicle membrane; IEA:Ensembl.
# GO_component	GO:0016021	integral component of membrane; NAS:ParkinsonsUK-UCL.
# GO_component	GO:0030133	transport vesicle; IDA:ParkinsonsUK-UCL.
# GO_component	GO:0031982	vesicle; IDA:ParkinsonsUK-UCL.
# GO_component	GO:0032585	multivesicular body membrane; NAS:ParkinsonsUK-UCL.
# GO_component	GO:0043005	neuron projection; IDA:ParkinsonsUK-UCL.
# GO_component	GO:0043025	neuronal cell body; IDA:ParkinsonsUK-UCL.
# GO_component	GO:0043202	lysosomal lumen; TAS:Reactome.
# GO_component	GO:1905103	integral component of lysosomal membrane; IDA:ParkinsonsUK-UCL.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0008270	zinc ion binding; ISS:ParkinsonsUK-UCL.
# GO_function	GO:0016887	ATPase activity; NAS:ParkinsonsUK-UCL.
# GO_function	GO:0019829	cation-transporting ATPase activity; IBA:GO_Central.
# GO_function	GO:0030145	manganese ion binding; ISS:ParkinsonsUK-UCL.
# GO_function	GO:0070300	phosphatidic acid binding; IDA:ParkinsonsUK-UCL.
# GO_function	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding; IDA:ParkinsonsUK-UCL.
# GO_function	GO:1903135	cupric ion binding; ISS:ParkinsonsUK-UCL.
# GO_process	GO:0006874	cellular calcium ion homeostasis; IDA:ParkinsonsUK-UCL.
# GO_process	GO:0006879	cellular iron ion homeostasis; IMP:ParkinsonsUK-UCL.
# GO_process	GO:0006882	cellular zinc ion homeostasis; IMP:ParkinsonsUK-UCL.
# GO_process	GO:0010821	regulation of mitochondrion organization; IDA:ParkinsonsUK-UCL.
# GO_process	GO:0016241	regulation of macroautophagy; IMP:ParkinsonsUK-UCL.
# GO_process	GO:0016243	regulation of autophagosome size; IDA:ParkinsonsUK-UCL.
# GO_process	GO:0030003	cellular cation homeostasis; TAS:ParkinsonsUK-UCL.
# GO_process	GO:0033157	regulation of intracellular protein transport; NAS:ParkinsonsUK-UCL.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0034599	cellular response to oxidative stress; IMP:ParkinsonsUK-UCL.
# GO_process	GO:0046777	protein autophosphorylation; TAS:ParkinsonsUK-UCL.
# GO_process	GO:0050714	positive regulation of protein secretion; IMP:ParkinsonsUK-UCL.
# GO_process	GO:0052548	regulation of endopeptidase activity; IMP:ParkinsonsUK-UCL.
# GO_process	GO:0055069	zinc ion homeostasis; IMP:ParkinsonsUK-UCL.
# GO_process	GO:0071287	cellular response to manganese ion; IMP:ParkinsonsUK-UCL.
# GO_process	GO:0071294	cellular response to zinc ion; TAS:ParkinsonsUK-UCL.
# GO_process	GO:1901215	negative regulation of neuron death; ISS:ParkinsonsUK-UCL.
# GO_process	GO:1903146	regulation of mitophagy; TAS:ParkinsonsUK-UCL.
# GO_process	GO:1903543	positive regulation of exosomal secretion; IDA:ParkinsonsUK-UCL.
# GO_process	GO:1904714	regulation of chaperone-mediated autophagy; TAS:ParkinsonsUK-UCL.
# GO_process	GO:1905037	autophagosome organization; IDA:ParkinsonsUK-UCL.
# GO_process	GO:1905122	polyamine import; IDA:ParkinsonsUK-UCL.
# GO_process	GO:1905123	regulation of glucosylceramidase activity; IEA:Ensembl.
# GO_process	GO:1905165	regulation of lysosomal protein catabolic process; IMP:ParkinsonsUK-UCL.
# GO_process	GO:1905166	negative regulation of lysosomal protein catabolic process; TAS:ParkinsonsUK-UCL.
# GO_process	GO:1990938	peptidyl-aspartic acid autophosphorylation; IMP:ParkinsonsUK-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005764	lysosome
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005773	vacuole
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0008289	lipid binding
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.70.150.10	-; 1.
# Gene3D	3.40.1110.10	-; 2.
# Gene3D	3.40.50.1000	-; 2.
# Genevisible	Q9NQ11	HS
# HGNC	HGNC:30213	ATP13A2
# INTERACTION	AT132_HUMAN	Q2M2I8 AAK1; NbExp=2; IntAct=EBI-6308763, EBI-1383433; O60238 BNIP3L; NbExp=2; IntAct=EBI-6308763, EBI-849893; O14976 GAK; NbExp=2; IntAct=EBI-6308763, EBI-714707; Q9UBN7 HDAC6; NbExp=2; IntAct=EBI-6308763, EBI-301697; P11142 HSPA8; NbExp=2; IntAct=EBI-6308763, EBI-351896; Q9BT88 SYT11; NbExp=2; IntAct=EBI-6308763, EBI-751770; O95070 YIF1A; NbExp=2; IntAct=EBI-6308763, EBI-2799703; 
# IntAct	Q9NQ11	49
# InterPro	IPR001757	P_typ_ATPase
# InterPro	IPR006544	P-type_TPase_V
# InterPro	IPR008250	ATPase_P-typ_transduc_dom_A
# InterPro	IPR018303	ATPase_P-typ_P_site
# InterPro	IPR023214	HAD-like_dom
# InterPro	IPR023299	ATPase_P-typ_cyto_domN
# KEGG_Brite	ko01000	Enzymes
# KEGG_Disease	H00057	[Neurodegenerative disease] Parkinson's disease (PD)
# KEGG_Disease	H00833	[Nervous system disease] Aceruloplasminemia
# KEGG_Disease	H01600	[Neurodegenerative disease] Parkinsonian syndrome
# MIM	606693	phenotype
# MIM	610513	gene
# Organism	AT132_HUMAN	Homo sapiens (Human)
# Orphanet	306674	Kufor-Rakeb syndrome
# Orphanet	314632	Parkinsonim due to ATP13A2 deficiency
# PROSITE	PS00154	ATPASE_E1_E2
# Pfam	PF00122	E1-E2_ATPase
# Pfam	PF12409	P5-ATPase
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	AT132_HUMAN	Probable cation-transporting ATPase 13A2
# RefSeq	NP_001135445	NM_001141973.2. [Q9NQ11-3]
# RefSeq	NP_001135446	NM_001141974.2. [Q9NQ11-2]
# RefSeq	NP_071372	NM_022089.3. [Q9NQ11-1]
# SEQUENCE CAUTION	Sequence=CAA08912.1; Type=Frameshift; Positions=1054; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	AT132_HUMAN	Membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Lysosome {ECO 0000269|PubMed 21542062, ECO 0000269|PubMed 22186024}. 
# SUPFAM	SSF56784	SSF56784; 3
# SUPFAM	SSF81660	SSF81660; 2
# TCDB	3.A.3.10	the p-type atpase (p-atpase) superfamily
# TIGRFAMs	TIGR01494	ATPase_P-type; 2
# TIGRFAMs	TIGR01657	P-ATPase-V
# TISSUE SPECIFICITY	Expressed in brain; protein levels are markedly increased in brain from subjects with Parkinson disease and subjects with dementia with Lewy bodies. Detected in pyramidal neurons located throughout the cingulate cortex (at protein level). In the substantia nigra, it is found in neuromelanin- positive dopaminergic neurons (at protein level). {ECO:0000269|PubMed	22186024}. 
# UCSC	uc001baa	human. [Q9NQ11-1]
# eggNOG	ENOG410XRCA	LUCA
# eggNOG	KOG0208	Eukaryota
BLAST	swissprot:AT132_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AT132_HUMAN
BioCyc	ZFISH:ENSG00000159363-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000159363-MONOMER
COXPRESdb	23400	http://coxpresdb.jp/data/gene/23400.shtml
CleanEx	HS_ATP13A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP13A2
DOI	10.1002/humu.20877	http://dx.doi.org/10.1002/humu.20877
DOI	10.1002/humu.21527	http://dx.doi.org/10.1002/humu.21527
DOI	10.1002/mds.22996	http://dx.doi.org/10.1002/mds.22996
DOI	10.1007/s10048-010-0259-0	http://dx.doi.org/10.1007/s10048-010-0259-0
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/ng1884	http://dx.doi.org/10.1038/ng1884
DOI	10.1093/hmg/ddr606	http://dx.doi.org/10.1093/hmg/ddr606
DOI	10.1093/hmg/dds089	http://dx.doi.org/10.1093/hmg/dds089
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.1212/01.wnl.0000260963.08711.08	http://dx.doi.org/10.1212/01.wnl.0000260963.08711.08
DOI	10.1212/01.wnl.0000310427.72236.68	http://dx.doi.org/10.1212/01.wnl.0000310427.72236.68
DOI	10.1212/01.wnl.0000335167.72412.68	http://dx.doi.org/10.1212/01.wnl.0000335167.72412.68
EC_number	EC:3.6.3.-	http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.-
EMBL	AJ009947	http://www.ebi.ac.uk/ena/data/view/AJ009947
EMBL	AK290210	http://www.ebi.ac.uk/ena/data/view/AK290210
EMBL	AL049569	http://www.ebi.ac.uk/ena/data/view/AL049569
EMBL	AL354615	http://www.ebi.ac.uk/ena/data/view/AL354615
EMBL	AL833966	http://www.ebi.ac.uk/ena/data/view/AL833966
EMBL	AY461712	http://www.ebi.ac.uk/ena/data/view/AY461712
EMBL	BC030267	http://www.ebi.ac.uk/ena/data/view/BC030267
EMBL	CH471134	http://www.ebi.ac.uk/ena/data/view/CH471134
EMBL	CH471134	http://www.ebi.ac.uk/ena/data/view/CH471134
ENZYME	3.6.3.-	http://enzyme.expasy.org/EC/3.6.3.-
Ensembl	ENST00000326735	http://www.ensembl.org/id/ENST00000326735
Ensembl	ENST00000341676	http://www.ensembl.org/id/ENST00000341676
Ensembl	ENST00000452699	http://www.ensembl.org/id/ENST00000452699
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005770	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005770
GO_component	GO:0005771	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005771
GO_component	GO:0005776	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005776
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0012506	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0012506
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030133	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030133
GO_component	GO:0031982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031982
GO_component	GO:0032585	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032585
GO_component	GO:0043005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043005
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0043202	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043202
GO_component	GO:1905103	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1905103
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0008270	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270
GO_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GO_function	GO:0019829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019829
GO_function	GO:0030145	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145
GO_function	GO:0070300	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070300
GO_function	GO:0080025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0080025
GO_function	GO:1903135	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903135
GO_process	GO:0006874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874
GO_process	GO:0006879	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006879
GO_process	GO:0006882	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006882
GO_process	GO:0010821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010821
GO_process	GO:0016241	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016241
GO_process	GO:0016243	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016243
GO_process	GO:0030003	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030003
GO_process	GO:0033157	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033157
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0034599	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034599
GO_process	GO:0046777	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046777
GO_process	GO:0050714	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050714
GO_process	GO:0052548	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052548
GO_process	GO:0055069	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055069
GO_process	GO:0071287	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071287
GO_process	GO:0071294	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071294
GO_process	GO:1901215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901215
GO_process	GO:1903146	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903146
GO_process	GO:1903543	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903543
GO_process	GO:1904714	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1904714
GO_process	GO:1905037	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1905037
GO_process	GO:1905122	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1905122
GO_process	GO:1905123	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1905123
GO_process	GO:1905165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1905165
GO_process	GO:1905166	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1905166
GO_process	GO:1990938	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990938
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005773	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005773
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.70.150.10	http://www.cathdb.info/version/latest/superfamily/2.70.150.10
Gene3D	3.40.1110.10	http://www.cathdb.info/version/latest/superfamily/3.40.1110.10
Gene3D	3.40.50.1000	http://www.cathdb.info/version/latest/superfamily/3.40.50.1000
GeneCards	ATP13A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP13A2
GeneID	23400	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23400
GeneTree	ENSGT00530000063001	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063001
HGNC	HGNC:30213	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:30213
HOGENOM	HOG000171813	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000171813&db=HOGENOM6
HOVERGEN	HBG065757	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG065757&db=HOVERGEN
HPA	CAB037038	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB037038
HPA	CAB037111	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB037111
HPA	HPA050910	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA050910
HPA	HPA054717	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA054717
InParanoid	Q9NQ11	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NQ11
IntAct	Q9NQ11	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NQ11*
IntEnz	3.6.3	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3
InterPro	IPR001757	http://www.ebi.ac.uk/interpro/entry/IPR001757
InterPro	IPR006544	http://www.ebi.ac.uk/interpro/entry/IPR006544
InterPro	IPR008250	http://www.ebi.ac.uk/interpro/entry/IPR008250
InterPro	IPR018303	http://www.ebi.ac.uk/interpro/entry/IPR018303
InterPro	IPR023214	http://www.ebi.ac.uk/interpro/entry/IPR023214
InterPro	IPR023299	http://www.ebi.ac.uk/interpro/entry/IPR023299
Jabion	23400	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=23400
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Disease	H00057	http://www.genome.jp/dbget-bin/www_bget?H00057
KEGG_Disease	H00833	http://www.genome.jp/dbget-bin/www_bget?H00833
KEGG_Disease	H01600	http://www.genome.jp/dbget-bin/www_bget?H01600
KEGG_Gene	hsa:23400	http://www.genome.jp/dbget-bin/www_bget?hsa:23400
KEGG_Orthology	KO:K13526	http://www.genome.jp/dbget-bin/www_bget?KO:K13526
MIM	606693	http://www.ncbi.nlm.nih.gov/omim/606693
MIM	610513	http://www.ncbi.nlm.nih.gov/omim/610513
MINT	MINT-4781194	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4781194
OMA	PPLWEPQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PPLWEPQ
Orphanet	306674	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=306674
Orphanet	314632	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=314632
OrthoDB	EOG091G01IL	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01IL
PROSITE	PS00154	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00154
PSORT	swissprot:AT132_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AT132_HUMAN
PSORT-B	swissprot:AT132_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AT132_HUMAN
PSORT2	swissprot:AT132_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AT132_HUMAN
Pfam	PF00122	http://pfam.xfam.org/family/PF00122
Pfam	PF12409	http://pfam.xfam.org/family/PF12409
PharmGKB	PA134897221	http://www.pharmgkb.org/do/serve?objId=PA134897221&objCls=Gene
Phobius	swissprot:AT132_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AT132_HUMAN
PhylomeDB	Q9NQ11	http://phylomedb.org/?seqid=Q9NQ11
ProteinModelPortal	Q9NQ11	http://www.proteinmodelportal.org/query/uniprot/Q9NQ11
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	16964263	http://www.ncbi.nlm.nih.gov/pubmed/16964263
PubMed	17485642	http://www.ncbi.nlm.nih.gov/pubmed/17485642
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18413573	http://www.ncbi.nlm.nih.gov/pubmed/18413573
PubMed	19015489	http://www.ncbi.nlm.nih.gov/pubmed/19015489
PubMed	19085912	http://www.ncbi.nlm.nih.gov/pubmed/19085912
PubMed	20683840	http://www.ncbi.nlm.nih.gov/pubmed/20683840
PubMed	20853184	http://www.ncbi.nlm.nih.gov/pubmed/20853184
PubMed	21542062	http://www.ncbi.nlm.nih.gov/pubmed/21542062
PubMed	22186024	http://www.ncbi.nlm.nih.gov/pubmed/22186024
PubMed	22388936	http://www.ncbi.nlm.nih.gov/pubmed/22388936
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_001135445	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001135445
RefSeq	NP_001135446	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001135446
RefSeq	NP_071372	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_071372
STRING	9606.ENSP00000327214	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000327214&targetmode=cogs
SUPFAM	SSF56784	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784
SUPFAM	SSF81660	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81660
TCDB	3.A.3.10	http://www.tcdb.org/search/result.php?tc=3.A.3.10
TIGRFAMs	TIGR01494	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01494
TIGRFAMs	TIGR01657	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01657
UCSC	uc001baa	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001baa&org=rat
UniGene	Hs.128866	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.128866
UniProtKB	AT132_HUMAN	http://www.uniprot.org/uniprot/AT132_HUMAN
UniProtKB-AC	Q9NQ11	http://www.uniprot.org/uniprot/Q9NQ11
charge	swissprot:AT132_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AT132_HUMAN
eggNOG	ENOG410XRCA	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRCA
eggNOG	KOG0208	http://eggnogapi.embl.de/nog_data/html/tree/KOG0208
epestfind	swissprot:AT132_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AT132_HUMAN
garnier	swissprot:AT132_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AT132_HUMAN
helixturnhelix	swissprot:AT132_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AT132_HUMAN
hmoment	swissprot:AT132_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AT132_HUMAN
iep	swissprot:AT132_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AT132_HUMAN
inforesidue	swissprot:AT132_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AT132_HUMAN
neXtProt	NX_Q9NQ11	http://www.nextprot.org/db/entry/NX_Q9NQ11
octanol	swissprot:AT132_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AT132_HUMAN
pepcoil	swissprot:AT132_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AT132_HUMAN
pepdigest	swissprot:AT132_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AT132_HUMAN
pepinfo	swissprot:AT132_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AT132_HUMAN
pepnet	swissprot:AT132_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AT132_HUMAN
pepstats	swissprot:AT132_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AT132_HUMAN
pepwheel	swissprot:AT132_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AT132_HUMAN
pepwindow	swissprot:AT132_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AT132_HUMAN
sigcleave	swissprot:AT132_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AT132_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TOM40_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O96008-1; Sequence=Displayed; Name=2; IsoId=O96008-2; Sequence=VSP_008589, VSP_008590; Note=No experimental confirmation available.; 
# AltName	TOM40_HUMAN	Protein Haymaker
# AltName	TOM40_HUMAN	Translocase of outer membrane 40 kDa subunit homolog
# AltName	TOM40_HUMAN	p38.5
# BioGrid	115716	121
# CCDS	CCDS12646	-. [O96008-1]
# ChiTaRS	TOMM40	human
# Ensembl	ENST00000252487	ENSP00000252487; ENSG00000130204. [O96008-1]
# Ensembl	ENST00000405636	ENSP00000385184; ENSG00000130204. [O96008-1]
# Ensembl	ENST00000426677	ENSP00000410339; ENSG00000130204. [O96008-1]
# Ensembl	ENST00000592434	ENSP00000466084; ENSG00000130204. [O96008-2]
# ExpressionAtlas	O96008	baseline and differential
# FUNCTION	TOM40_HUMAN	Channel-forming protein essential for import of protein precursors into mitochondria. {ECO 0000250, ECO 0000269|PubMed 15644312}. 
# GO_component	GO:0005654	nucleoplasm; IDA:HPA.
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0005739	mitochondrion; IDA:HPA.
# GO_component	GO:0005741	mitochondrial outer membrane; TAS:Reactome.
# GO_component	GO:0005742	mitochondrial outer membrane translocase complex; IDA:BHF-UCL.
# GO_component	GO:0016021	integral component of membrane; IDA:BHF-UCL.
# GO_component	GO:0031307	integral component of mitochondrial outer membrane; ISS:BHF-UCL.
# GO_component	GO:0046930	pore complex; IEA:UniProtKB-KW.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0008320	protein transmembrane transporter activity; ISS:BHF-UCL.
# GO_function	GO:0015266	protein channel activity; IBA:GO_Central.
# GO_function	GO:0015288	porin activity; IEA:UniProtKB-KW.
# GO_process	GO:0006626	protein targeting to mitochondrion; IMP:UniProtKB.
# GO_process	GO:0006811	ion transport; IEA:UniProtKB-KW.
# GO_process	GO:0016236	macroautophagy; TAS:Reactome.
# GO_process	GO:0030150	protein import into mitochondrial matrix; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006605	protein targeting
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006914	autophagy
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.40.160.10	-; 1.
# Genevisible	O96008	HS
# HGNC	HGNC:18001	TOMM40
# IntAct	O96008	28
# InterPro	IPR023614	Porin_dom
# InterPro	IPR027246	Porin_Euk/Tom40
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Pathway	ko05014	Amyotrophic lateral sclerosis (ALS)
# MIM	608061	gene
# Organism	TOM40_HUMAN	Homo sapiens (Human)
# Pfam	PF01459	Porin_3
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-1268020	Mitochondrial protein import
# Reactome	R-HSA-5205685	Pink/Parkin Mediated Mitophagy
# RecName	TOM40_HUMAN	Mitochondrial import receptor subunit TOM40 homolog
# RefSeq	NP_001122388	NM_001128916.1. [O96008-1]
# RefSeq	NP_001122389	NM_001128917.1. [O96008-1]
# RefSeq	NP_006105	NM_006114.2. [O96008-1]
# SIMILARITY	Belongs to the Tom40 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	TOM40_HUMAN	Mitochondrion outer membrane {ECO 0000269|PubMed 15644312}; Multi-pass membrane protein {ECO 0000269|PubMed 15644312}. 
# SUBUNIT	TOM40_HUMAN	Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with mitochondrial targeting sequences. {ECO 0000269|PubMed 12198123, ECO 0000269|PubMed 15644312, ECO 0000269|PubMed 18331822}. 
# TCDB	1.B.8.2	the mitochondrial and plastid porin (mpp) family
# TopDownProteomics	O96008-1	-. [O96008-1]
# UCSC	uc002ozx	human. [O96008-1]
# eggNOG	ENOG410XS2U	LUCA
# eggNOG	KOG3296	Eukaryota
BLAST	swissprot:TOM40_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TOM40_HUMAN
BioCyc	ZFISH:ENSG00000130204-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000130204-MONOMER
COXPRESdb	10452	http://coxpresdb.jp/data/gene/10452.shtml
CleanEx	HS_TOMM40	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TOMM40
DOI	10.1002/ijc.1555	http://dx.doi.org/10.1002/ijc.1555
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.bbrc.2008.02.150	http://dx.doi.org/10.1016/j.bbrc.2008.02.150
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1074/jbc.M205613200	http://dx.doi.org/10.1074/jbc.M205613200
DOI	10.1074/jbc.M413816200	http://dx.doi.org/10.1074/jbc.M413816200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF043250	http://www.ebi.ac.uk/ena/data/view/AF043250
EMBL	AF043251	http://www.ebi.ac.uk/ena/data/view/AF043251
EMBL	AF043252	http://www.ebi.ac.uk/ena/data/view/AF043252
EMBL	AF043253	http://www.ebi.ac.uk/ena/data/view/AF043253
EMBL	AF050154	http://www.ebi.ac.uk/ena/data/view/AF050154
EMBL	AF316398	http://www.ebi.ac.uk/ena/data/view/AF316398
EMBL	AF316399	http://www.ebi.ac.uk/ena/data/view/AF316399
EMBL	AF316401	http://www.ebi.ac.uk/ena/data/view/AF316401
EMBL	AF316402	http://www.ebi.ac.uk/ena/data/view/AF316402
EMBL	BC001779	http://www.ebi.ac.uk/ena/data/view/BC001779
EMBL	BC006413	http://www.ebi.ac.uk/ena/data/view/BC006413
EMBL	BC012134	http://www.ebi.ac.uk/ena/data/view/BC012134
EMBL	BC017224	http://www.ebi.ac.uk/ena/data/view/BC017224
EMBL	BC047528	http://www.ebi.ac.uk/ena/data/view/BC047528
Ensembl	ENST00000252487	http://www.ensembl.org/id/ENST00000252487
Ensembl	ENST00000405636	http://www.ensembl.org/id/ENST00000405636
Ensembl	ENST00000426677	http://www.ensembl.org/id/ENST00000426677
Ensembl	ENST00000592434	http://www.ensembl.org/id/ENST00000592434
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005741	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005741
GO_component	GO:0005742	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005742
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0031307	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031307
GO_component	GO:0046930	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046930
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0008320	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008320
GO_function	GO:0015266	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015266
GO_function	GO:0015288	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015288
GO_process	GO:0006626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006626
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0016236	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016236
GO_process	GO:0030150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030150
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006914	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006914
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.40.160.10	http://www.cathdb.info/version/latest/superfamily/2.40.160.10
GeneCards	TOMM40	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TOMM40
GeneID	10452	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10452
GeneTree	ENSGT00390000003308	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000003308
H-InvDB	HIX0041357	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0041357
HGNC	HGNC:18001	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18001
HOGENOM	HOG000007440	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007440&db=HOGENOM6
HOVERGEN	HBG054707	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054707&db=HOVERGEN
HPA	CAB009156	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB009156
HPA	HPA036231	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA036231
HPA	HPA036232	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA036232
InParanoid	O96008	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O96008
IntAct	O96008	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O96008*
InterPro	IPR023614	http://www.ebi.ac.uk/interpro/entry/IPR023614
InterPro	IPR027246	http://www.ebi.ac.uk/interpro/entry/IPR027246
Jabion	10452	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10452
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Gene	hsa:10452	http://www.genome.jp/dbget-bin/www_bget?hsa:10452
KEGG_Orthology	KO:K11518	http://www.genome.jp/dbget-bin/www_bget?KO:K11518
KEGG_Pathway	ko05014	http://www.genome.jp/kegg-bin/show_pathway?ko05014
MIM	608061	http://www.ncbi.nlm.nih.gov/omim/608061
MINT	MINT-3003386	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3003386
OMA	GVTMRAS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GVTMRAS
OrthoDB	EOG091G0MNA	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0MNA
PSORT	swissprot:TOM40_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TOM40_HUMAN
PSORT-B	swissprot:TOM40_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TOM40_HUMAN
PSORT2	swissprot:TOM40_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TOM40_HUMAN
Pfam	PF01459	http://pfam.xfam.org/family/PF01459
PharmGKB	PA38274	http://www.pharmgkb.org/do/serve?objId=PA38274&objCls=Gene
Phobius	swissprot:TOM40_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TOM40_HUMAN
PhylomeDB	O96008	http://phylomedb.org/?seqid=O96008
ProteinModelPortal	O96008	http://www.proteinmodelportal.org/query/uniprot/O96008
PubMed	10520737	http://www.ncbi.nlm.nih.gov/pubmed/10520737
PubMed	11745481	http://www.ncbi.nlm.nih.gov/pubmed/11745481
PubMed	12198123	http://www.ncbi.nlm.nih.gov/pubmed/12198123
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15644312	http://www.ncbi.nlm.nih.gov/pubmed/15644312
PubMed	18331822	http://www.ncbi.nlm.nih.gov/pubmed/18331822
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-1268020	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1268020
Reactome	R-HSA-5205685	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5205685
RefSeq	NP_001122388	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001122388
RefSeq	NP_001122389	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001122389
RefSeq	NP_006105	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006105
STRING	9606.ENSP00000252487	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000252487&targetmode=cogs
TCDB	1.B.8.2	http://www.tcdb.org/search/result.php?tc=1.B.8.2
UCSC	uc002ozx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ozx&org=rat
UniGene	Hs.655909	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.655909
UniProtKB	TOM40_HUMAN	http://www.uniprot.org/uniprot/TOM40_HUMAN
UniProtKB-AC	O96008	http://www.uniprot.org/uniprot/O96008
charge	swissprot:TOM40_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TOM40_HUMAN
eggNOG	ENOG410XS2U	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS2U
eggNOG	KOG3296	http://eggnogapi.embl.de/nog_data/html/tree/KOG3296
epestfind	swissprot:TOM40_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TOM40_HUMAN
garnier	swissprot:TOM40_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TOM40_HUMAN
helixturnhelix	swissprot:TOM40_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TOM40_HUMAN
hmoment	swissprot:TOM40_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TOM40_HUMAN
iep	swissprot:TOM40_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TOM40_HUMAN
inforesidue	swissprot:TOM40_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TOM40_HUMAN
neXtProt	NX_O96008	http://www.nextprot.org/db/entry/NX_O96008
octanol	swissprot:TOM40_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TOM40_HUMAN
pepcoil	swissprot:TOM40_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TOM40_HUMAN
pepdigest	swissprot:TOM40_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TOM40_HUMAN
pepinfo	swissprot:TOM40_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TOM40_HUMAN
pepnet	swissprot:TOM40_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TOM40_HUMAN
pepstats	swissprot:TOM40_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TOM40_HUMAN
pepwheel	swissprot:TOM40_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TOM40_HUMAN
pepwindow	swissprot:TOM40_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TOM40_HUMAN
sigcleave	swissprot:TOM40_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TOM40_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNN4_HUMAN	IKCa1
# AltName	KCNN4_HUMAN	KCa3.1
# AltName	KCNN4_HUMAN	KCa4
# AltName	KCNN4_HUMAN	Putative Gardos channel
# BioGrid	109984	6
# ChiTaRS	KCNN4	human
# DISEASE	KCNN4_HUMAN	Dehydrated hereditary stomatocytosis 2 (DHS2) [MIM 616689]  An autosomal dominant hemolytic anemia characterized by primary erythrocyte dehydration. Erythrocytes exhibit decreased total cation and potassium content that are not accompanied by a proportional net gain of sodium and water. Affected individuals typically manifest mild to moderate compensated hemolytic anemia, with an increased erythrocyte mean corpuscular hemoglobin concentration and a decreased osmotic fragility, both of which reflect cellular dehydration. Their red cells exhibit a panel of various shape abnormalities such as elliptocytes, hemighosts, schizocytes, and very rare stomatocytic cells. Complications such as splenomegaly and cholelithiasis, resulting from increased red cell trapping in the spleen and elevated bilirubin levels, respectively, may occur. {ECO 0000269|PubMed 26148990, ECO 0000269|PubMed 26178367, ECO 0000269|PubMed 26198474}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00228	Enflurane
# DrugBank	DB00257	Clotrimazole
# DrugBank	DB00468	Quinine
# DrugBank	DB00721	Procaine
# DrugBank	DB01110	Miconazole
# DrugBank	DB01159	Halothane
# Ensembl	ENST00000262888	ENSP00000262888; ENSG00000104783
# ExpressionAtlas	O15554	baseline and differential
# FUNCTION	KCNN4_HUMAN	Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed 26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin (PubMed 17157250, PubMed 18796614). {ECO 0000269|PubMed 17157250, ECO 0000269|PubMed 18796614, ECO 0000269|PubMed 26148990}. 
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IC:BHF-UCL.
# GO_component	GO:0031982	vesicle; IDA:BHF-UCL.
# GO_function	GO:0005267	potassium channel activity; TAS:Reactome.
# GO_function	GO:0015269	calcium-activated potassium channel activity; IDA:UniProtKB.
# GO_function	GO:0016286	small conductance calcium-activated potassium channel activity; IEA:InterPro.
# GO_function	GO:0019903	protein phosphatase binding; IPI:BHF-UCL.
# GO_process	GO:0002376	immune system process; IEA:UniProtKB-KW.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0006816	calcium ion transport; IDA:BHF-UCL.
# GO_process	GO:0006884	cell volume homeostasis; IEA:Ensembl.
# GO_process	GO:0006952	defense response; TAS:ProtInc.
# GO_process	GO:0030322	stabilization of membrane potential; IDA:BHF-UCL.
# GO_process	GO:0045332	phospholipid translocation; IEA:Ensembl.
# GO_process	GO:0046541	saliva secretion; IEA:Ensembl.
# GO_process	GO:0050714	positive regulation of protein secretion; IEA:Ensembl.
# GO_process	GO:0050862	positive regulation of T cell receptor signaling pathway; IDA:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0061024	membrane organization
# Genevisible	O15554	HS
# HGNC	HGNC:6293	KCNN4
# INDUCTION	KCNN4_HUMAN	Up-regulated by phorbol myristate acetate (PMA) and phytohemagglutinin (PHA) in T-cells. 
# IntAct	O15554	2
# InterPro	IPR004178	CaM-bd_dom
# InterPro	IPR013099	K_chnl_dom
# InterPro	IPR015449	K_chnl_Ca-activ_SK
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04970	Salivary secretion
# KEGG_Pathway	ko04974	Protein digestion and absorption
# MIM	602754	gene
# MIM	616689	phenotype
# Organism	KCNN4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10153	PTHR10153
# PTM	KCNN4_HUMAN	Phosphorylation at His-358 by NDKB activates the channel, and conversely it's dephosphorylation by PHPT1 inhibits the channel. {ECO 0000269|PubMed 17157250}. 
# Pfam	PF02888	CaMBD
# Pfam	PF03530	SK_channel
# Pfam	PF07885	Ion_trans_2
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-1296052	Ca2+ activated K+ channels
# RecName	KCNN4_HUMAN	Intermediate conductance calcium-activated potassium channel protein 4
# RefSeq	NP_002241	NM_002250.2
# SIMILARITY	Belongs to the potassium channel KCNN family. KCa3.1/KCNN4 subfamily. {ECO	0000305}.
# SMART	SM01053	CaMBD
# SUBCELLULAR LOCATION	KCNN4_HUMAN	Cell membrane {ECO 0000269|PubMed 26148990}; Multi-pass membrane protein {ECO 0000255}. 
# SUBUNIT	KCNN4_HUMAN	Heterotetramer of potassium channel proteins (Probable). Interacts with MTMR6. {ECO 0000269|PubMed 10026195, ECO 0000269|PubMed 15831468, ECO 0000305}. 
# SUPFAM	SSF81327	SSF81327
# TCDB	1.A.1.16	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	KCNN4_HUMAN	Widely expressed in non-excitable tissues. 
# UCSC	uc002oxl	human
# eggNOG	ENOG410XT9D	LUCA
# eggNOG	KOG3684	Eukaryota
BLAST	swissprot:KCNN4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNN4_HUMAN
BioCyc	ZFISH:ENSG00000104783-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000104783-MONOMER
COXPRESdb	3783	http://coxpresdb.jp/data/gene/3783.shtml
CleanEx	HS_KCNN4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNN4
DIP	DIP-48598N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48598N
DOI	10.1002/ajh.24117	http://dx.doi.org/10.1002/ajh.24117
DOI	10.1006/geno.1998.5333	http://dx.doi.org/10.1006/geno.1998.5333
DOI	10.1016/j.molcel.2006.11.012	http://dx.doi.org/10.1016/j.molcel.2006.11.012
DOI	10.1073/pnas.0803678105	http://dx.doi.org/10.1073/pnas.0803678105
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1073/pnas.94.20.11013	http://dx.doi.org/10.1073/pnas.94.20.11013
DOI	10.1073/pnas.94.21.11651	http://dx.doi.org/10.1073/pnas.94.21.11651
DOI	10.1074/jbc.272.52.32723	http://dx.doi.org/10.1074/jbc.272.52.32723
DOI	10.1074/jbc.274.9.5746	http://dx.doi.org/10.1074/jbc.274.9.5746
DOI	10.1074/jbc.M003941200	http://dx.doi.org/10.1074/jbc.M003941200
DOI	10.1074/jbc.M105231200	http://dx.doi.org/10.1074/jbc.M105231200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1128/MCB.25.9.3630-3638.2005	http://dx.doi.org/10.1128/MCB.25.9.3630-3638.2005
DOI	10.1182/blood-2015-04-642496	http://dx.doi.org/10.1182/blood-2015-04-642496
DOI	10.1182/blood-2015-07-657957	http://dx.doi.org/10.1182/blood-2015-07-657957
DrugBank	DB00228	http://www.drugbank.ca/drugs/DB00228
DrugBank	DB00257	http://www.drugbank.ca/drugs/DB00257
DrugBank	DB00468	http://www.drugbank.ca/drugs/DB00468
DrugBank	DB00721	http://www.drugbank.ca/drugs/DB00721
DrugBank	DB01110	http://www.drugbank.ca/drugs/DB01110
DrugBank	DB01159	http://www.drugbank.ca/drugs/DB01159
EMBL	AF000972	http://www.ebi.ac.uk/ena/data/view/AF000972
EMBL	AF022150	http://www.ebi.ac.uk/ena/data/view/AF022150
EMBL	AF022797	http://www.ebi.ac.uk/ena/data/view/AF022797
EMBL	AF033021	http://www.ebi.ac.uk/ena/data/view/AF033021
EMBL	AF053403	http://www.ebi.ac.uk/ena/data/view/AF053403
EMBL	AF305731	http://www.ebi.ac.uk/ena/data/view/AF305731
EMBL	AF305732	http://www.ebi.ac.uk/ena/data/view/AF305732
EMBL	AF305733	http://www.ebi.ac.uk/ena/data/view/AF305733
EMBL	AF305734	http://www.ebi.ac.uk/ena/data/view/AF305734
EMBL	AF305735	http://www.ebi.ac.uk/ena/data/view/AF305735
EMBL	AF395661	http://www.ebi.ac.uk/ena/data/view/AF395661
EMBL	BC015337	http://www.ebi.ac.uk/ena/data/view/BC015337
EMBL	BT007426	http://www.ebi.ac.uk/ena/data/view/BT007426
EMBL	CH471126	http://www.ebi.ac.uk/ena/data/view/CH471126
Ensembl	ENST00000262888	http://www.ensembl.org/id/ENST00000262888
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0031982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031982
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_function	GO:0015269	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015269
GO_function	GO:0016286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016286
GO_function	GO:0019903	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019903
GO_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0006884	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006884
GO_process	GO:0006952	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006952
GO_process	GO:0030322	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030322
GO_process	GO:0045332	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045332
GO_process	GO:0046541	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046541
GO_process	GO:0050714	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050714
GO_process	GO:0050862	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050862
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
GeneCards	KCNN4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNN4
GeneID	3783	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3783
GeneTree	ENSGT00500000044784	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00500000044784
HGNC	HGNC:6293	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6293
HOGENOM	HOG000276908	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276908&db=HOGENOM6
HOVERGEN	HBG052241	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052241&db=HOVERGEN
HPA	HPA053841	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA053841
HPA	HPA059622	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA059622
InParanoid	O15554	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O15554
IntAct	O15554	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O15554*
InterPro	IPR004178	http://www.ebi.ac.uk/interpro/entry/IPR004178
InterPro	IPR013099	http://www.ebi.ac.uk/interpro/entry/IPR013099
InterPro	IPR015449	http://www.ebi.ac.uk/interpro/entry/IPR015449
Jabion	3783	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3783
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3783	http://www.genome.jp/dbget-bin/www_bget?hsa:3783
KEGG_Orthology	KO:K04945	http://www.genome.jp/dbget-bin/www_bget?KO:K04945
KEGG_Pathway	ko04970	http://www.genome.jp/kegg-bin/show_pathway?ko04970
KEGG_Pathway	ko04974	http://www.genome.jp/kegg-bin/show_pathway?ko04974
MIM	602754	http://www.ncbi.nlm.nih.gov/omim/602754
MIM	616689	http://www.ncbi.nlm.nih.gov/omim/616689
OMA	NINFTFR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NINFTFR
OrthoDB	EOG091G09X0	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G09X0
PANTHER	PTHR10153	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10153
PSORT	swissprot:KCNN4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNN4_HUMAN
PSORT-B	swissprot:KCNN4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNN4_HUMAN
PSORT2	swissprot:KCNN4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNN4_HUMAN
Pfam	PF02888	http://pfam.xfam.org/family/PF02888
Pfam	PF03530	http://pfam.xfam.org/family/PF03530
Pfam	PF07885	http://pfam.xfam.org/family/PF07885
PharmGKB	PA222	http://www.pharmgkb.org/do/serve?objId=PA222&objCls=Gene
Phobius	swissprot:KCNN4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNN4_HUMAN
PhylomeDB	O15554	http://phylomedb.org/?seqid=O15554
ProteinModelPortal	O15554	http://www.proteinmodelportal.org/query/uniprot/O15554
PubMed	10026195	http://www.ncbi.nlm.nih.gov/pubmed/10026195
PubMed	10961988	http://www.ncbi.nlm.nih.gov/pubmed/10961988
PubMed	11425865	http://www.ncbi.nlm.nih.gov/pubmed/11425865
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15831468	http://www.ncbi.nlm.nih.gov/pubmed/15831468
PubMed	17157250	http://www.ncbi.nlm.nih.gov/pubmed/17157250
PubMed	18796614	http://www.ncbi.nlm.nih.gov/pubmed/18796614
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	26148990	http://www.ncbi.nlm.nih.gov/pubmed/26148990
PubMed	26178367	http://www.ncbi.nlm.nih.gov/pubmed/26178367
PubMed	26198474	http://www.ncbi.nlm.nih.gov/pubmed/26198474
PubMed	9326665	http://www.ncbi.nlm.nih.gov/pubmed/9326665
PubMed	9380751	http://www.ncbi.nlm.nih.gov/pubmed/9380751
PubMed	9407042	http://www.ncbi.nlm.nih.gov/pubmed/9407042
PubMed	9693050	http://www.ncbi.nlm.nih.gov/pubmed/9693050
Reactome	R-HSA-1296052	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296052
RefSeq	NP_002241	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002241
SMART	SM01053	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01053
SMR	O15554	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O15554
STRING	9606.ENSP00000262888	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000262888&targetmode=cogs
SUPFAM	SSF81327	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81327
TCDB	1.A.1.16	http://www.tcdb.org/search/result.php?tc=1.A.1.16
UCSC	uc002oxl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002oxl&org=rat
UniGene	Hs.10082	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.10082
UniProtKB	KCNN4_HUMAN	http://www.uniprot.org/uniprot/KCNN4_HUMAN
UniProtKB-AC	O15554	http://www.uniprot.org/uniprot/O15554
charge	swissprot:KCNN4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNN4_HUMAN
eggNOG	ENOG410XT9D	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XT9D
eggNOG	KOG3684	http://eggnogapi.embl.de/nog_data/html/tree/KOG3684
epestfind	swissprot:KCNN4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNN4_HUMAN
garnier	swissprot:KCNN4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNN4_HUMAN
helixturnhelix	swissprot:KCNN4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNN4_HUMAN
hmoment	swissprot:KCNN4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNN4_HUMAN
iep	swissprot:KCNN4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNN4_HUMAN
inforesidue	swissprot:KCNN4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNN4_HUMAN
neXtProt	NX_O15554	http://www.nextprot.org/db/entry/NX_O15554
octanol	swissprot:KCNN4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNN4_HUMAN
pepcoil	swissprot:KCNN4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNN4_HUMAN
pepdigest	swissprot:KCNN4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNN4_HUMAN
pepinfo	swissprot:KCNN4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNN4_HUMAN
pepnet	swissprot:KCNN4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNN4_HUMAN
pepstats	swissprot:KCNN4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNN4_HUMAN
pepwheel	swissprot:KCNN4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNN4_HUMAN
pepwindow	swissprot:KCNN4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNN4_HUMAN
sigcleave	swissprot:KCNN4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNN4_HUMAN
## Database	ID	URL or Descriptions
# AltName	BEST2_HUMAN	Vitelliform macular dystrophy 2-like protein 1
# Ensembl	ENST00000042931	ENSP00000042931; ENSG00000039987
# Ensembl	ENST00000549706	ENSP00000448310; ENSG00000039987
# Ensembl	ENST00000553030	ENSP00000447203; ENSG00000039987
# ExpressionAtlas	Q8NFU1	baseline and differential
# FUNCTION	BEST2_HUMAN	Forms calcium-sensitive chloride channels. Permeable to bicarbonate. {ECO 0000269|PubMed 11904445, ECO 0000269|PubMed 12907679, ECO 0000269|PubMed 18400985}. 
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0005929	cilium; ISS:HGNC.
# GO_component	GO:0034707	chloride channel complex; ISS:BHF-UCL.
# GO_function	GO:0005254	chloride channel activity; IEA:UniProtKB-KW.
# GO_process	GO:0007608	sensory perception of smell; ISS:HGNC.
# GO_process	GO:0051899	membrane depolarization; ISS:HGNC.
# GO_process	GO:1902476	chloride transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005929	cilium
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q8NFU1	HS
# HGNC	HGNC:17107	BEST2
# InterPro	IPR000615	Bestrophin
# InterPro	IPR021134	Bestrophin/UPF0187
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko04970	Salivary secretion
# MIM	607335	gene
# Organism	BEST2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10736	PTHR10736
# Pfam	PF01062	Bestrophin
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	BEST2_HUMAN	Bestrophin-2
# RefSeq	NP_060152	NM_017682.2
# RefSeq	XP_005260020	XM_005259963.3
# SEQUENCE CAUTION	Sequence=BAA90970.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the bestrophin family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	BEST2_HUMAN	Cell membrane; Multi-pass membrane protein. 
# TCDB	1.A.46.1	the anion channel-forming bestrophin (bestrophin) family
# TISSUE SPECIFICITY	Mainly confined to the retinal pigment epithelium and colon. {ECO:0000269|PubMed	12032738}. 
# UCSC	uc002mux	human
# eggNOG	ENOG410XS3J	LUCA
# eggNOG	KOG3547	Eukaryota
BLAST	swissprot:BEST2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:BEST2_HUMAN
BioCyc	ZFISH:ENSG00000039987-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000039987-MONOMER
COXPRESdb	54831	http://coxpresdb.jp/data/gene/54831.shtml
CleanEx	HS_BEST2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_BEST2
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.ejhg.5200796	http://dx.doi.org/10.1038/sj.ejhg.5200796
DOI	10.1073/pnas.052692999	http://dx.doi.org/10.1073/pnas.052692999
DOI	10.1074/jbc.M306150200	http://dx.doi.org/10.1074/jbc.M306150200
DOI	10.1152/ajpcell.00398.2007	http://dx.doi.org/10.1152/ajpcell.00398.2007
EMBL	AF440756	http://www.ebi.ac.uk/ena/data/view/AF440756
EMBL	AK000139	http://www.ebi.ac.uk/ena/data/view/AK000139
EMBL	AY515705	http://www.ebi.ac.uk/ena/data/view/AY515705
Ensembl	ENST00000042931	http://www.ensembl.org/id/ENST00000042931
Ensembl	ENST00000549706	http://www.ensembl.org/id/ENST00000549706
Ensembl	ENST00000553030	http://www.ensembl.org/id/ENST00000553030
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005929	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005929
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_process	GO:0007608	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007608
GO_process	GO:0051899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051899
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005929	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005929
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	BEST2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=BEST2
GeneID	54831	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54831
GeneTree	ENSGT00390000002997	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002997
HGNC	HGNC:17107	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17107
HOGENOM	HOG000115678	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000115678&db=HOGENOM6
HOVERGEN	HBG044928	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG044928&db=HOVERGEN
HPA	HPA046229	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA046229
InParanoid	Q8NFU1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8NFU1
InterPro	IPR000615	http://www.ebi.ac.uk/interpro/entry/IPR000615
InterPro	IPR021134	http://www.ebi.ac.uk/interpro/entry/IPR021134
Jabion	54831	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=54831
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:54831	http://www.genome.jp/dbget-bin/www_bget?hsa:54831
KEGG_Orthology	KO:K13879	http://www.genome.jp/dbget-bin/www_bget?KO:K13879
KEGG_Pathway	ko04970	http://www.genome.jp/kegg-bin/show_pathway?ko04970
MIM	607335	http://www.ncbi.nlm.nih.gov/omim/607335
OMA	DRYWNDS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DRYWNDS
OrthoDB	EOG091G06XO	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G06XO
PANTHER	PTHR10736	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10736
PSORT	swissprot:BEST2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:BEST2_HUMAN
PSORT-B	swissprot:BEST2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:BEST2_HUMAN
PSORT2	swissprot:BEST2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:BEST2_HUMAN
Pfam	PF01062	http://pfam.xfam.org/family/PF01062
PharmGKB	PA162377481	http://www.pharmgkb.org/do/serve?objId=PA162377481&objCls=Gene
Phobius	swissprot:BEST2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:BEST2_HUMAN
PhylomeDB	Q8NFU1	http://phylomedb.org/?seqid=Q8NFU1
ProteinModelPortal	Q8NFU1	http://www.proteinmodelportal.org/query/uniprot/Q8NFU1
PubMed	11904445	http://www.ncbi.nlm.nih.gov/pubmed/11904445
PubMed	12032738	http://www.ncbi.nlm.nih.gov/pubmed/12032738
PubMed	12907679	http://www.ncbi.nlm.nih.gov/pubmed/12907679
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	18400985	http://www.ncbi.nlm.nih.gov/pubmed/18400985
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_060152	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060152
RefSeq	XP_005260020	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005260020
SMR	Q8NFU1	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8NFU1
STRING	9606.ENSP00000042931	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000042931&targetmode=cogs
TCDB	1.A.46.1	http://www.tcdb.org/search/result.php?tc=1.A.46.1
UCSC	uc002mux	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002mux&org=rat
UniGene	Hs.435611	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.435611
UniProtKB	BEST2_HUMAN	http://www.uniprot.org/uniprot/BEST2_HUMAN
UniProtKB-AC	Q8NFU1	http://www.uniprot.org/uniprot/Q8NFU1
charge	swissprot:BEST2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:BEST2_HUMAN
eggNOG	ENOG410XS3J	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS3J
eggNOG	KOG3547	http://eggnogapi.embl.de/nog_data/html/tree/KOG3547
epestfind	swissprot:BEST2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:BEST2_HUMAN
garnier	swissprot:BEST2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:BEST2_HUMAN
helixturnhelix	swissprot:BEST2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:BEST2_HUMAN
hmoment	swissprot:BEST2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:BEST2_HUMAN
iep	swissprot:BEST2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:BEST2_HUMAN
inforesidue	swissprot:BEST2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:BEST2_HUMAN
neXtProt	NX_Q8NFU1	http://www.nextprot.org/db/entry/NX_Q8NFU1
octanol	swissprot:BEST2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:BEST2_HUMAN
pepcoil	swissprot:BEST2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:BEST2_HUMAN
pepdigest	swissprot:BEST2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:BEST2_HUMAN
pepinfo	swissprot:BEST2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:BEST2_HUMAN
pepnet	swissprot:BEST2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:BEST2_HUMAN
pepstats	swissprot:BEST2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:BEST2_HUMAN
pepwheel	swissprot:BEST2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:BEST2_HUMAN
pepwindow	swissprot:BEST2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:BEST2_HUMAN
sigcleave	swissprot:BEST2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:BEST2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	MOT1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P53985-1; Sequence=Displayed; Name=2; IsoId=P53985-2; Sequence=VSP_056191; Note=No experimental confirmation available.; 
# AltName	MOT1_HUMAN	Solute carrier family 16 member 1
# BioGrid	112454	24
# CCDS	CCDS858	-. [P53985-1]
# CDD	cd06174	MFS
# ChiTaRS	SLC16A1	human
# DISEASE	MOT1_HUMAN	Familial hyperinsulinemic hypoglycemia 7 (HHF7) [MIM 610021]  Dominantly inherited hypoglycemic disorder characterized by inappropriate insulin secretion during anaerobic exercise or on pyruvate load. {ECO 0000269|PubMed 17701893}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	MOT1_HUMAN	Monocarboxylate transporter 1 deficiency (MCT1D) [MIM 616095]  A metabolic disorder characterized by recurrent ketoacidosis, a pathologic state due to ketone formation exceeding ketone utilization. The clinical consequences of ketoacidosis are vomiting, osmotic diuresis, dehydration, and Kussmaul breathing. The condition may progress to decreased consciousness and, ultimately, death. {ECO 0000269|PubMed 25390740}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	MOT1_HUMAN	Symptomatic deficiency in lactate transport (SDLT) [MIM 245340]  Deficiency of lactate transporter may result in an acidic intracellular environment created by muscle activity with consequent degeneration of muscle and release of myoglobin and creatine kinase. This defect might compromise extreme performance in otherwise healthy individuals. {ECO 0000269|PubMed 10590411}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00119	Pyruvic acid
# DrugBank	DB00175	Pravastatin
# DrugBank	DB00313	Valproic Acid
# DrugBank	DB00345	Aminohippurate
# DrugBank	DB00415	Ampicillin
# DrugBank	DB00529	Foscarnet
# DrugBank	DB00563	Methotrexate
# DrugBank	DB00627	Niacin
# DrugBank	DB00731	Nateglinide
# DrugBank	DB00936	Salicylic acid
# DrugBank	DB01032	Probenecid
# DrugBank	DB01440	Gamma Hydroxybutyric Acid
# DrugBank	DB03166	Acetic acid
# DrugBank	DB03793	Benzoic Acid
# DrugBank	DB04398	Lactic Acid
# DrugBank	DB04552	Niflumic Acid
# Ensembl	ENST00000369626	ENSP00000358640; ENSG00000155380. [P53985-1]
# Ensembl	ENST00000538576	ENSP00000441065; ENSG00000155380. [P53985-1]
# Ensembl	ENST00000628110	ENSP00000485688; ENSG00000281917. [P53985-1]
# Ensembl	ENST00000630362	ENSP00000486000; ENSG00000281917. [P53985-1]
# ExpressionAtlas	P53985	baseline and differential
# FUNCTION	MOT1_HUMAN	Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis. {ECO 0000269|PubMed 17701893}. 
# GO_component	GO:0005739	mitochondrion; IEA:Ensembl.
# GO_component	GO:0005813	centrosome; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0008028	monocarboxylic acid transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015129	lactate transmembrane transporter activity; EXP:Reactome.
# GO_function	GO:0015130	mevalonate transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_function	GO:0097159	organic cyclic compound binding; IEA:Ensembl.
# GO_process	GO:0006090	pyruvate metabolic process; TAS:Reactome.
# GO_process	GO:0006629	lipid metabolic process; IEA:Ensembl.
# GO_process	GO:0015718	monocarboxylic acid transport; TAS:ProtInc.
# GO_process	GO:0015728	mevalonate transport; TAS:ProtInc.
# GO_process	GO:0032094	response to food; IEA:Ensembl.
# GO_process	GO:0035879	plasma membrane lactate transport; ISS:UniProtKB.
# GO_process	GO:0042593	glucose homeostasis; IEA:Ensembl.
# GO_process	GO:0050796	regulation of insulin secretion; IEA:Ensembl.
# GO_process	GO:0050900	leukocyte migration; TAS:Reactome.
# GO_process	GO:0051297	centrosome organization; IMP:UniProtKB.
# GO_process	GO:0051780	behavioral response to nutrient; IEA:Ensembl.
# GO_process	GO:0071407	cellular response to organic cyclic compound; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005815	microtubule organizing center
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0048870	cell motility
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P53985	HS
# HGNC	HGNC:10922	SLC16A1
# IntAct	P53985	12
# InterPro	IPR004743	MCT
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# InterPro	IPR030757	MCT1
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H01248	[Musculoskeletal disease] Erythrocyte lactate transporter defect
# KEGG_Disease	H01267	[Inherited metabolic disease] Familial hyperinsulinemic hypoglycemia (HHF)
# MIM	245340	phenotype
# MIM	600682	gene
# MIM	610021	phenotype
# MIM	616095	phenotype
# MISCELLANEOUS	MOT1_HUMAN	Overexpression in pancreatic beta-cells triggers insulin secretion in response to pyruvate, causing hyperinsulemia and hypoglycemia during strenuous exercise. 
# Organism	MOT1_HUMAN	Homo sapiens (Human)
# Orphanet	165991	Exercise-induced hyperinsulinism
# Orphanet	171690	Metabolic myopathy due to lactate transporter defect
# PANTHER	PTHR11360:SF24	PTHR11360:SF24
# PIR	A55568	A55568
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-210991	Basigin interactions
# Reactome	R-HSA-433692	Proton-coupled monocarboxylate transport
# Reactome	R-HSA-70268	Pyruvate metabolism
# RecName	MOT1_HUMAN	Monocarboxylate transporter 1
# RefSeq	NP_001159968	NM_001166496.1. [P53985-1]
# RefSeq	NP_003042	NM_003051.3. [P53985-1]
# RefSeq	XP_011540328	XM_011542026.2. [P53985-1]
# RefSeq	XP_011540329	XM_011542027.2. [P53985-1]
# SIMILARITY	Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	MOT1_HUMAN	Cell membrane {ECO 0000269|PubMed 15505343, ECO 0000269|PubMed 17127621, ECO 0000269|PubMed 24390345}; Multi- pass membrane protein {ECO 0000269|PubMed 15505343, ECO 0000269|PubMed 17127621, ECO 0000269|PubMed 24390345}. 
# SUBUNIT	Interacts with EMB. Interaction with either BSG or EMB is required for expression at the cell membrane (By similarity). Interacts with BSG; this is required for expression at the cell membrane. {ECO:0000250, ECO	0000269|PubMed:17127621}. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.1.13	the major facilitator superfamily (mfs)
# TIGRFAMs	TIGR00892	2A0113
# TISSUE SPECIFICITY	Detected in heart and in blood lymphocytes and monocytes (at protein level). Widely expressed. {ECO:0000269|PubMed	15505343}. 
# UCSC	uc001ecx	human. [P53985-1]
# WEB RESOURCE	MOT1_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/SLC16A1ID44046ch1p13.html";
# eggNOG	COG0477	LUCA
# eggNOG	KOG2504	Eukaryota
BLAST	swissprot:MOT1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MOT1_HUMAN
BioCyc	MetaCyc:ENSG00000155380-MONOMER	http://biocyc.org/getid?id=MetaCyc:ENSG00000155380-MONOMER
BioCyc	ZFISH:ENSG00000155380-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000155380-MONOMER
COXPRESdb	6566	http://coxpresdb.jp/data/gene/6566.shtml
CleanEx	HS_SLC16A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC16A1
DOI	10.1002/(SICI)1097-4598(200001)23:1<90::AID-MUS12>3.0.CO	http://dx.doi.org/10.1002/(SICI)1097-4598(200001)23:1<90::AID-MUS12>3.0.CO
DOI	10.1002/iub.572	http://dx.doi.org/10.1002/iub.572
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/bbrc.2002.6763	http://dx.doi.org/10.1006/bbrc.2002.6763
DOI	10.1006/geno.1994.1532	http://dx.doi.org/10.1006/geno.1994.1532
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/nature12828	http://dx.doi.org/10.1038/nature12828
DOI	10.1056/NEJMoa1407778	http://dx.doi.org/10.1056/NEJMoa1407778
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/mcp.M800588-MCP200	http://dx.doi.org/10.1074/mcp.M800588-MCP200
DOI	10.1080/09687860600841967	http://dx.doi.org/10.1080/09687860600841967
DOI	10.1086/520960	http://dx.doi.org/10.1086/520960
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1369/jhc.4A6306.2004	http://dx.doi.org/10.1369/jhc.4A6306.2004
DrugBank	DB00119	http://www.drugbank.ca/drugs/DB00119
DrugBank	DB00175	http://www.drugbank.ca/drugs/DB00175
DrugBank	DB00313	http://www.drugbank.ca/drugs/DB00313
DrugBank	DB00345	http://www.drugbank.ca/drugs/DB00345
DrugBank	DB00415	http://www.drugbank.ca/drugs/DB00415
DrugBank	DB00529	http://www.drugbank.ca/drugs/DB00529
DrugBank	DB00563	http://www.drugbank.ca/drugs/DB00563
DrugBank	DB00627	http://www.drugbank.ca/drugs/DB00627
DrugBank	DB00731	http://www.drugbank.ca/drugs/DB00731
DrugBank	DB00936	http://www.drugbank.ca/drugs/DB00936
DrugBank	DB01032	http://www.drugbank.ca/drugs/DB01032
DrugBank	DB01440	http://www.drugbank.ca/drugs/DB01440
DrugBank	DB03166	http://www.drugbank.ca/drugs/DB03166
DrugBank	DB03793	http://www.drugbank.ca/drugs/DB03793
DrugBank	DB04398	http://www.drugbank.ca/drugs/DB04398
DrugBank	DB04552	http://www.drugbank.ca/drugs/DB04552
EMBL	AJ438945	http://www.ebi.ac.uk/ena/data/view/AJ438945
EMBL	AL158844	http://www.ebi.ac.uk/ena/data/view/AL158844
EMBL	AL162079	http://www.ebi.ac.uk/ena/data/view/AL162079
EMBL	BC026317	http://www.ebi.ac.uk/ena/data/view/BC026317
EMBL	BC045664	http://www.ebi.ac.uk/ena/data/view/BC045664
EMBL	CH471122	http://www.ebi.ac.uk/ena/data/view/CH471122
EMBL	L31801	http://www.ebi.ac.uk/ena/data/view/L31801
Ensembl	ENST00000369626	http://www.ensembl.org/id/ENST00000369626
Ensembl	ENST00000538576	http://www.ensembl.org/id/ENST00000538576
Ensembl	ENST00000628110	http://www.ensembl.org/id/ENST00000628110
Ensembl	ENST00000630362	http://www.ensembl.org/id/ENST00000630362
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005813
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0008028	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008028
GO_function	GO:0015129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015129
GO_function	GO:0015130	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015130
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_function	GO:0097159	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097159
GO_process	GO:0006090	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006090
GO_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GO_process	GO:0015718	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015718
GO_process	GO:0015728	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015728
GO_process	GO:0032094	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032094
GO_process	GO:0035879	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035879
GO_process	GO:0042593	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042593
GO_process	GO:0050796	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050796
GO_process	GO:0050900	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050900
GO_process	GO:0051297	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051297
GO_process	GO:0051780	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051780
GO_process	GO:0071407	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071407
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005815	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005815
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC16A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC16A1
GeneID	6566	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6566
GeneTree	ENSGT00760000118926	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118926
H-InvDB	HIX0000897	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0000897
HGNC	HGNC:10922	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10922
HOGENOM	HOG000280688	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280688&db=HOGENOM6
HOVERGEN	HBG006384	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006384&db=HOVERGEN
HPA	CAB017489	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB017489
HPA	HPA003324	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA003324
InParanoid	P53985	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P53985
IntAct	P53985	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P53985*
InterPro	IPR004743	http://www.ebi.ac.uk/interpro/entry/IPR004743
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
InterPro	IPR030757	http://www.ebi.ac.uk/interpro/entry/IPR030757
Jabion	6566	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6566
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H01248	http://www.genome.jp/dbget-bin/www_bget?H01248
KEGG_Disease	H01267	http://www.genome.jp/dbget-bin/www_bget?H01267
KEGG_Gene	hsa:6566	http://www.genome.jp/dbget-bin/www_bget?hsa:6566
KEGG_Orthology	KO:K08179	http://www.genome.jp/dbget-bin/www_bget?KO:K08179
MIM	245340	http://www.ncbi.nlm.nih.gov/omim/245340
MIM	600682	http://www.ncbi.nlm.nih.gov/omim/600682
MIM	610021	http://www.ncbi.nlm.nih.gov/omim/610021
MIM	616095	http://www.ncbi.nlm.nih.gov/omim/616095
MINT	MINT-5004345	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5004345
OMA	HMLAPLS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HMLAPLS
Orphanet	165991	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=165991
Orphanet	171690	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=171690
OrthoDB	EOG091G05SW	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05SW
PANTHER	PTHR11360:SF24	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11360:SF24
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:MOT1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MOT1_HUMAN
PSORT-B	swissprot:MOT1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MOT1_HUMAN
PSORT2	swissprot:MOT1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MOT1_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA35813	http://www.pharmgkb.org/do/serve?objId=PA35813&objCls=Gene
Phobius	swissprot:MOT1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MOT1_HUMAN
PhylomeDB	P53985	http://phylomedb.org/?seqid=P53985
ProteinModelPortal	P53985	http://www.proteinmodelportal.org/query/uniprot/P53985
PubMed	10590411	http://www.ncbi.nlm.nih.gov/pubmed/10590411
PubMed	11944921	http://www.ncbi.nlm.nih.gov/pubmed/11944921
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15505343	http://www.ncbi.nlm.nih.gov/pubmed/15505343
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	17127621	http://www.ncbi.nlm.nih.gov/pubmed/17127621
PubMed	17701893	http://www.ncbi.nlm.nih.gov/pubmed/17701893
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	19369195	http://www.ncbi.nlm.nih.gov/pubmed/19369195
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	22162139	http://www.ncbi.nlm.nih.gov/pubmed/22162139
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	24390345	http://www.ncbi.nlm.nih.gov/pubmed/24390345
PubMed	25390740	http://www.ncbi.nlm.nih.gov/pubmed/25390740
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	7835905	http://www.ncbi.nlm.nih.gov/pubmed/7835905
Reactome	R-HSA-210991	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-210991
Reactome	R-HSA-433692	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-433692
Reactome	R-HSA-70268	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-70268
RefSeq	NP_001159968	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001159968
RefSeq	NP_003042	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003042
RefSeq	XP_011540328	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011540328
RefSeq	XP_011540329	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011540329
STRING	9606.ENSP00000358640	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000358640&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.13	http://www.tcdb.org/search/result.php?tc=2.A.1.13
TIGRFAMs	TIGR00892	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00892
UCSC	uc001ecx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001ecx&org=rat
UniGene	Hs.75231	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.75231
UniProtKB	MOT1_HUMAN	http://www.uniprot.org/uniprot/MOT1_HUMAN
UniProtKB-AC	P53985	http://www.uniprot.org/uniprot/P53985
charge	swissprot:MOT1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MOT1_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG2504	http://eggnogapi.embl.de/nog_data/html/tree/KOG2504
epestfind	swissprot:MOT1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MOT1_HUMAN
garnier	swissprot:MOT1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MOT1_HUMAN
helixturnhelix	swissprot:MOT1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MOT1_HUMAN
hmoment	swissprot:MOT1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MOT1_HUMAN
iep	swissprot:MOT1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MOT1_HUMAN
inforesidue	swissprot:MOT1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MOT1_HUMAN
neXtProt	NX_P53985	http://www.nextprot.org/db/entry/NX_P53985
octanol	swissprot:MOT1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MOT1_HUMAN
pepcoil	swissprot:MOT1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MOT1_HUMAN
pepdigest	swissprot:MOT1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MOT1_HUMAN
pepinfo	swissprot:MOT1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MOT1_HUMAN
pepnet	swissprot:MOT1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MOT1_HUMAN
pepstats	swissprot:MOT1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MOT1_HUMAN
pepwheel	swissprot:MOT1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MOT1_HUMAN
pepwindow	swissprot:MOT1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MOT1_HUMAN
sigcleave	swissprot:MOT1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MOT1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	P_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q04671-1; Sequence=Displayed; Name=2; IsoId=Q04671-2; Sequence=VSP_012284; Name=3; IsoId=Q04671-3; Sequence=VSP_012285, VSP_012286; Note=No experimental confirmation available.; 
# AltName	P_HUMAN	Melanocyte-specific transporter protein
# AltName	P_HUMAN	Pink-eyed dilution protein homolog
# BioGrid	111002	3
# CCDS	CCDS10020	-. [Q04671-1]
# CCDS	CCDS73701	-. [Q04671-2]
# DISEASE	P_HUMAN	Albinism, oculocutaneous, 2 (OCA2) [MIM 203200]  An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Although affected infants may appear at birth to have complete absence of melanin pigment, most patients acquire small amounts of pigment with age. Visual anomalies include decreased acuity and nystagmus. The phenotype is highly variable. The hair of affected individuals may turn darker with age, and pigmented nevi or freckles may be seen. African and African American individuals may have yellow hair and blue-gray or hazel irides. One phenotypic variant, 'brown OCA,' has been described in African and African American populations and is characterized by light brown hair and skin color and gray to tan irides. {ECO 0000269|PubMed 10649493, ECO 0000269|PubMed 10671067, ECO 0000269|PubMed 10987646, ECO 0000269|PubMed 12713581, ECO 0000269|PubMed 12727022, ECO 0000269|PubMed 12876664, ECO 0000269|PubMed 17385796, ECO 0000269|PubMed 23504663, ECO 0000269|PubMed 7762554, ECO 0000269|PubMed 7874125, ECO 0000269|PubMed 9259203}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000353809	ENSP00000261276; ENSG00000104044. [Q04671-2]
# Ensembl	ENST00000354638	ENSP00000346659; ENSG00000104044. [Q04671-1]
# ExpressionAtlas	Q04671	baseline and differential
# FUNCTION	P_HUMAN	Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color. {ECO 0000269|PubMed 11310796, ECO 0000269|PubMed 15262401, ECO 0000269|PubMed 18252222, ECO 0000269|PubMed 22234890, ECO 0000269|PubMed 7601462}. 
# GO_component	GO:0005737	cytoplasm; TAS:ProtInc.
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005789	endoplasmic reticulum membrane; IDA:UniProtKB.
# GO_component	GO:0010008	endosome membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_component	GO:0033162	melanosome membrane; IDA:UniProtKB.
# GO_function	GO:0005215	transporter activity; TAS:ProtInc.
# GO_function	GO:0005302	L-tyrosine transmembrane transporter activity; TAS:ProtInc.
# GO_process	GO:0006726	eye pigment biosynthetic process; TAS:ProtInc.
# GO_process	GO:0007286	spermatid development; IEA:Ensembl.
# GO_process	GO:0008283	cell proliferation; IEA:Ensembl.
# GO_process	GO:0030318	melanocyte differentiation; IEA:Ensembl.
# GO_process	GO:0042438	melanin biosynthetic process; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0008283	cell proliferation
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0019748	secondary metabolic process
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0048856	anatomical structure development
# Genevisible	Q04671	HS
# HGNC	HGNC:8101	OCA2
# INDUCTION	P_HUMAN	Expression is under the control of an enhancer element that is encoded in an intron of the close-by HERC2 gene. The enhancer element containing the T-allele of the polymorphism rs12913832 mediates binding of the transcription factors HLTF, LEF1 and MITF and increases OCA2 expression. In contrast, transcription factor binding and OCA2 expression are reduced in carriers of the C-allele of polymorphism rs12913832. Thus, people homozygous for the C-allele have light-colored eyes, while people homozygous for the T-allele of polymorphism rs12913832 most often have brown eyes. {ECO 0000269|PubMed 18172690, ECO 0000269|PubMed 18252222, ECO 0000269|PubMed 22234890}. 
# InterPro	IPR004680	Cit_transptr-like_dom
# KEGG_Disease	H00168	[Inherited metabolic disease; Skin and connective tissue disease; Eye disease] Oculocutaneous albinism (OCA)
# MIM	203200	phenotype
# MIM	227220	phenotype
# MIM	611409	gene
# Organism	P_HUMAN	Homo sapiens (Human)
# Orphanet	177901	Prader-Willi syndrome due to paternal deletion of 15q11q13 type 1
# Orphanet	177904	Prader-Willi syndrome due to paternal deletion of 15q11q13 type 2
# Orphanet	72	Angelman syndrome
# Orphanet	79432	Oculocutaneous albinism type 2
# Orphanet	98754	Prader-Willi syndrome due to maternal uniparental disomy of chromosome 15
# PIR	A57173	A57173
# PIR	S28911	S28911
# POLYMORPHISM	P_HUMAN	Genetic variants in OCA2 define the skin/hair/eye pigmentation variation locus 1 (SHEP1) [MIM 227220]; also known as skin/hair/eye pigmentation type 1, blue/nonblue eyes or skin/hair/eye pigmentation type 1, blue/brown eyes or skin/hair/eye pigmentation type 1, blond/brown hair or eye color, brown/blue or eye color, blue/nonblue or eye color type 3 (EYCL3) or brown eye color type 2 (BEY2) or hair color type 3 (HCL3). Hair, eye and skin pigmentation are among the most visible examples of human phenotypic variation, with a broad normal range that is subject to substantial geographic stratification. In the case of skin, individuals tend to have lighter pigmentation with increasing distance from the equator. By contrast, the majority of variation in human eye and hair color is found among individuals of European ancestry, with most other human populations fixed for brown eyes and black hair. OCA2 polymorphisms may act as a penetrance modifier of the risk of malignant melanoma. {ECO 0000269|PubMed 17236130, ECO 0000269|PubMed 17952075, ECO 0000269|PubMed 18172690, ECO 0000269|PubMed 18252221, ECO 0000269|PubMed 18252222}. 
# Pfam	PF03600	CitMHS
# Proteomes	UP000005640	Chromosome 15
# Reactome	R-HSA-5662702	Melanin biosynthesis
# RecName	P_HUMAN	P protein
# RefSeq	NP_000266	NM_000275.2. [Q04671-1]
# RefSeq	NP_001287913	NM_001300984.1. [Q04671-2]
# SIMILARITY	Belongs to the CitM (TC 2.A.11) transporter family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	P_HUMAN	Melanosome membrane {ECO 0000269|PubMed 7601462}; Multi-pass membrane protein {ECO 0000269|PubMed 7601462}. 
# TCDB	2.A.45.2	the arsenite-antimonite (arsb) efflux family
# UCSC	uc001zbh	human. [Q04671-1]
# WEB RESOURCE	P_HUMAN	Name=Albinism database (ADB); Note=P mutations; URL="http //albinismdb.med.umn.edu/oca2mut.html"; 
# WEB RESOURCE	P_HUMAN	Name=Mutations of the P gene; Note=Retina International's Scientific Newsletter; URL="http //www.retina-international.org/files/sci-news/pgenemut.htm"; 
# WEB RESOURCE	P_HUMAN	Name=Protein Spotlight; Note=Questioning colour - Issue 54 of January 2005; URL="http //web.expasy.org/spotlight/back_issues/054";
# eggNOG	COG1055	LUCA
# eggNOG	KOG2639	Eukaryota
BLAST	swissprot:P_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:P_HUMAN
BioCyc	ZFISH:HS02540-MONOMER	http://biocyc.org/getid?id=ZFISH:HS02540-MONOMER
COXPRESdb	4948	http://coxpresdb.jp/data/gene/4948.shtml
CleanEx	HS_OCA2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_OCA2
DOI	10.1002/(SICI)1098-1004(1997)10:2<175::AID-HUMU12>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1997)10:2<175::AID-HUMU12>3.0.CO
DOI	10.1002/(SICI)1098-1004(1998)12:6<434::AID-HUMU15>3.3.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1998)12:6<434::AID-HUMU15>3.3.CO
DOI	10.1002/(SICI)1098-1004(1999)13:2<99::AID-HUMU2>3.3.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1999)13:2<99::AID-HUMU2>3.3.CO
DOI	10.1002/(SICI)1098-1004(200002)15:2<166::AID-HUMU5>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(200002)15:2<166::AID-HUMU5>3.0.CO
DOI	10.1002/humu.22315	http://dx.doi.org/10.1002/humu.22315
DOI	10.1002/pd.1713	http://dx.doi.org/10.1002/pd.1713
DOI	10.1007/s00439-007-0460-x	http://dx.doi.org/10.1007/s00439-007-0460-x
DOI	10.1007/s004390051090	http://dx.doi.org/10.1007/s004390051090
DOI	10.1016/0888-7543(95)80220-G	http://dx.doi.org/10.1016/0888-7543(95)80220-G
DOI	10.1016/S0923-1811(03)00005-7	http://dx.doi.org/10.1016/S0923-1811(03)00005-7
DOI	10.1016/j.ajhg.2007.10.003	http://dx.doi.org/10.1016/j.ajhg.2007.10.003
DOI	10.1016/j.ajhg.2007.11.005	http://dx.doi.org/10.1016/j.ajhg.2007.11.005
DOI	10.1016/j.tig.2004.06.010	http://dx.doi.org/10.1016/j.tig.2004.06.010
DOI	10.1034/j.1600-0749.2001.140203.x	http://dx.doi.org/10.1034/j.1600-0749.2001.140203.x
DOI	10.1034/j.1600-0749.2001.140508.x	http://dx.doi.org/10.1034/j.1600-0749.2001.140508.x
DOI	10.1038/361072a0	http://dx.doi.org/10.1038/361072a0
DOI	10.1038/ng.2007.13	http://dx.doi.org/10.1038/ng.2007.13
DOI	10.1038/sj.ejhg.5201415	http://dx.doi.org/10.1038/sj.ejhg.5201415
DOI	10.1046/j.1523-1747.2003.12127.x	http://dx.doi.org/10.1046/j.1523-1747.2003.12127.x
DOI	10.1086/377569	http://dx.doi.org/10.1086/377569
DOI	10.1086/510885	http://dx.doi.org/10.1086/510885
DOI	10.1101/gr.128652.111	http://dx.doi.org/10.1101/gr.128652.111
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1126/science.257.5073.1121	http://dx.doi.org/10.1126/science.257.5073.1121
EMBL	BC012097	http://www.ebi.ac.uk/ena/data/view/BC012097
EMBL	M97901	http://www.ebi.ac.uk/ena/data/view/M97901
EMBL	M99564	http://www.ebi.ac.uk/ena/data/view/M99564
EMBL	U19153	http://www.ebi.ac.uk/ena/data/view/U19153
EMBL	U19153	http://www.ebi.ac.uk/ena/data/view/U19153
EMBL	U19154	http://www.ebi.ac.uk/ena/data/view/U19154
EMBL	U19154	http://www.ebi.ac.uk/ena/data/view/U19154
EMBL	U19155	http://www.ebi.ac.uk/ena/data/view/U19155
EMBL	U19155	http://www.ebi.ac.uk/ena/data/view/U19155
EMBL	U19156	http://www.ebi.ac.uk/ena/data/view/U19156
EMBL	U19157	http://www.ebi.ac.uk/ena/data/view/U19157
EMBL	U19157	http://www.ebi.ac.uk/ena/data/view/U19157
EMBL	U19158	http://www.ebi.ac.uk/ena/data/view/U19158
EMBL	U19158	http://www.ebi.ac.uk/ena/data/view/U19158
EMBL	U19159	http://www.ebi.ac.uk/ena/data/view/U19159
EMBL	U19159	http://www.ebi.ac.uk/ena/data/view/U19159
EMBL	U19160	http://www.ebi.ac.uk/ena/data/view/U19160
EMBL	U19160	http://www.ebi.ac.uk/ena/data/view/U19160
EMBL	U19161	http://www.ebi.ac.uk/ena/data/view/U19161
EMBL	U19161	http://www.ebi.ac.uk/ena/data/view/U19161
EMBL	U19162	http://www.ebi.ac.uk/ena/data/view/U19162
EMBL	U19162	http://www.ebi.ac.uk/ena/data/view/U19162
EMBL	U19163	http://www.ebi.ac.uk/ena/data/view/U19163
EMBL	U19163	http://www.ebi.ac.uk/ena/data/view/U19163
EMBL	U19164	http://www.ebi.ac.uk/ena/data/view/U19164
EMBL	U19164	http://www.ebi.ac.uk/ena/data/view/U19164
EMBL	U19165	http://www.ebi.ac.uk/ena/data/view/U19165
EMBL	U19165	http://www.ebi.ac.uk/ena/data/view/U19165
EMBL	U19166	http://www.ebi.ac.uk/ena/data/view/U19166
EMBL	U19166	http://www.ebi.ac.uk/ena/data/view/U19166
EMBL	U19167	http://www.ebi.ac.uk/ena/data/view/U19167
EMBL	U19167	http://www.ebi.ac.uk/ena/data/view/U19167
EMBL	U19168	http://www.ebi.ac.uk/ena/data/view/U19168
EMBL	U19168	http://www.ebi.ac.uk/ena/data/view/U19168
EMBL	U19169	http://www.ebi.ac.uk/ena/data/view/U19169
EMBL	U19169	http://www.ebi.ac.uk/ena/data/view/U19169
EMBL	U19170	http://www.ebi.ac.uk/ena/data/view/U19170
EMBL	U19171	http://www.ebi.ac.uk/ena/data/view/U19171
EMBL	U19172	http://www.ebi.ac.uk/ena/data/view/U19172
EMBL	U19173	http://www.ebi.ac.uk/ena/data/view/U19173
EMBL	U19174	http://www.ebi.ac.uk/ena/data/view/U19174
EMBL	U19175	http://www.ebi.ac.uk/ena/data/view/U19175
EMBL	U19176	http://www.ebi.ac.uk/ena/data/view/U19176
Ensembl	ENST00000353809	http://www.ensembl.org/id/ENST00000353809
Ensembl	ENST00000354638	http://www.ensembl.org/id/ENST00000354638
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0010008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010008
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0033162	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033162
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0005302	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005302
GO_process	GO:0006726	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006726
GO_process	GO:0007286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007286
GO_process	GO:0008283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008283
GO_process	GO:0030318	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030318
GO_process	GO:0042438	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042438
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0008283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008283
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0019748	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019748
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GeneCards	OCA2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=OCA2
GeneID	4948	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4948
GeneTree	ENSGT00390000017120	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000017120
H-InvDB	HIX0012054	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0012054
HGNC	HGNC:8101	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:8101
HOGENOM	HOG000047303	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000047303&db=HOGENOM6
HOVERGEN	HBG008343	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG008343&db=HOVERGEN
HPA	HPA036403	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA036403
InParanoid	Q04671	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q04671
IntAct	Q04671	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q04671*
InterPro	IPR004680	http://www.ebi.ac.uk/interpro/entry/IPR004680
Jabion	4948	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=4948
KEGG_Disease	H00168	http://www.genome.jp/dbget-bin/www_bget?H00168
KEGG_Gene	hsa:4948	http://www.genome.jp/dbget-bin/www_bget?hsa:4948
MIM	203200	http://www.ncbi.nlm.nih.gov/omim/203200
MIM	227220	http://www.ncbi.nlm.nih.gov/omim/227220
MIM	611409	http://www.ncbi.nlm.nih.gov/omim/611409
OMA	QVTHNWT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QVTHNWT
Orphanet	177901	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=177901
Orphanet	177904	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=177904
Orphanet	72	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=72
Orphanet	79432	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=79432
Orphanet	98754	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98754
OrthoDB	EOG091G03O6	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G03O6
PSORT	swissprot:P_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:P_HUMAN
PSORT-B	swissprot:P_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:P_HUMAN
PSORT2	swissprot:P_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:P_HUMAN
Pfam	PF03600	http://pfam.xfam.org/family/PF03600
PharmGKB	PA31890	http://www.pharmgkb.org/do/serve?objId=PA31890&objCls=Gene
Phobius	swissprot:P_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:P_HUMAN
PhylomeDB	Q04671	http://phylomedb.org/?seqid=Q04671
ProteinModelPortal	Q04671	http://www.proteinmodelportal.org/query/uniprot/Q04671
PubMed	10094567	http://www.ncbi.nlm.nih.gov/pubmed/10094567
PubMed	10649493	http://www.ncbi.nlm.nih.gov/pubmed/10649493
PubMed	10671067	http://www.ncbi.nlm.nih.gov/pubmed/10671067
PubMed	10987646	http://www.ncbi.nlm.nih.gov/pubmed/10987646
PubMed	11310796	http://www.ncbi.nlm.nih.gov/pubmed/11310796
PubMed	11601658	http://www.ncbi.nlm.nih.gov/pubmed/11601658
PubMed	12163334	http://www.ncbi.nlm.nih.gov/pubmed/12163334
PubMed	12713581	http://www.ncbi.nlm.nih.gov/pubmed/12713581
PubMed	12727022	http://www.ncbi.nlm.nih.gov/pubmed/12727022
PubMed	12876664	http://www.ncbi.nlm.nih.gov/pubmed/12876664
PubMed	1509264	http://www.ncbi.nlm.nih.gov/pubmed/1509264
PubMed	15262401	http://www.ncbi.nlm.nih.gov/pubmed/15262401
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15889046	http://www.ncbi.nlm.nih.gov/pubmed/15889046
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	17236130	http://www.ncbi.nlm.nih.gov/pubmed/17236130
PubMed	17385796	http://www.ncbi.nlm.nih.gov/pubmed/17385796
PubMed	17952075	http://www.ncbi.nlm.nih.gov/pubmed/17952075
PubMed	18172690	http://www.ncbi.nlm.nih.gov/pubmed/18172690
PubMed	18252221	http://www.ncbi.nlm.nih.gov/pubmed/18252221
PubMed	18252222	http://www.ncbi.nlm.nih.gov/pubmed/18252222
PubMed	22234890	http://www.ncbi.nlm.nih.gov/pubmed/22234890
PubMed	23504663	http://www.ncbi.nlm.nih.gov/pubmed/23504663
PubMed	7601462	http://www.ncbi.nlm.nih.gov/pubmed/7601462
PubMed	7762554	http://www.ncbi.nlm.nih.gov/pubmed/7762554
PubMed	7874125	http://www.ncbi.nlm.nih.gov/pubmed/7874125
PubMed	8421497	http://www.ncbi.nlm.nih.gov/pubmed/8421497
PubMed	9259203	http://www.ncbi.nlm.nih.gov/pubmed/9259203
Reactome	R-HSA-5662702	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5662702
RefSeq	NP_000266	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000266
RefSeq	NP_001287913	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001287913
STRING	9606.ENSP00000346659	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000346659&targetmode=cogs
TCDB	2.A.45.2	http://www.tcdb.org/search/result.php?tc=2.A.45.2
UCSC	uc001zbh	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001zbh&org=rat
UniGene	Hs.654411	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.654411
UniProtKB	P_HUMAN	http://www.uniprot.org/uniprot/P_HUMAN
UniProtKB-AC	Q04671	http://www.uniprot.org/uniprot/Q04671
charge	swissprot:P_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:P_HUMAN
eggNOG	COG1055	http://eggnogapi.embl.de/nog_data/html/tree/COG1055
eggNOG	KOG2639	http://eggnogapi.embl.de/nog_data/html/tree/KOG2639
epestfind	swissprot:P_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:P_HUMAN
garnier	swissprot:P_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:P_HUMAN
helixturnhelix	swissprot:P_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:P_HUMAN
hmoment	swissprot:P_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:P_HUMAN
iep	swissprot:P_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:P_HUMAN
inforesidue	swissprot:P_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:P_HUMAN
neXtProt	NX_Q04671	http://www.nextprot.org/db/entry/NX_Q04671
octanol	swissprot:P_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:P_HUMAN
pepcoil	swissprot:P_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:P_HUMAN
pepdigest	swissprot:P_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:P_HUMAN
pepinfo	swissprot:P_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:P_HUMAN
pepnet	swissprot:P_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:P_HUMAN
pepstats	swissprot:P_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:P_HUMAN
pepwheel	swissprot:P_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:P_HUMAN
pepwindow	swissprot:P_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:P_HUMAN
sigcleave	swissprot:P_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:P_HUMAN
## Database	ID	URL or Descriptions
# AltName	SHRM2_HUMAN	Apical-like protein
# AltName	SHRM2_HUMAN	Protein APXL
# ChiTaRS	SHROOM2	human
# DOMAIN	SHRM2_HUMAN	The ASD1 domain mediates F-actin binding. {ECO 0000250}. 
# Ensembl	ENST00000380913	ENSP00000370299; ENSG00000146950
# ExpressionAtlas	Q13796	baseline and differential
# FUNCTION	SHRM2_HUMAN	May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO 0000250}. 
# GO_component	GO:0005737	cytoplasm; IEA:UniProtKB-KW.
# GO_component	GO:0005856	cytoskeleton; ISS:UniProtKB.
# GO_component	GO:0005874	microtubule; IEA:UniProtKB-KW.
# GO_component	GO:0005886	plasma membrane; ISS:UniProtKB.
# GO_component	GO:0005913	cell-cell adherens junction; ISS:UniProtKB.
# GO_component	GO:0005923	bicellular tight junction; ISS:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; ISS:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0003779	actin binding; ISS:UniProtKB.
# GO_function	GO:0008013	beta-catenin binding; ISS:UniProtKB.
# GO_function	GO:0015280	ligand-gated sodium channel activity; TAS:ProtInc.
# GO_function	GO:0051015	actin filament binding; ISS:UniProtKB.
# GO_process	GO:0002089	lens morphogenesis in camera-type eye; ISS:HGNC.
# GO_process	GO:0007420	brain development; ISS:HGNC.
# GO_process	GO:0008057	eye pigment granule organization; ISS:HGNC.
# GO_process	GO:0016477	cell migration; ISS:UniProtKB.
# GO_process	GO:0032401	establishment of melanosome localization; ISS:HGNC.
# GO_process	GO:0032438	melanosome organization; ISS:HGNC.
# GO_process	GO:0043010	camera-type eye development; ISS:HGNC.
# GO_process	GO:0043482	cellular pigment accumulation; ISS:HGNC.
# GO_process	GO:0043583	ear development; ISS:HGNC.
# GO_process	GO:0045176	apical protein localization; ISS:HGNC.
# GO_process	GO:0048593	camera-type eye morphogenesis; ISS:HGNC.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005856	cytoskeleton
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008092	cytoskeletal protein binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0043473	pigmentation
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0048870	cell motility
# Gene3D	2.30.42.10	-; 1.
# Genevisible	Q13796	HS
# HGNC	HGNC:630	SHROOM2
# INTERACTION	SHRM2_HUMAN	P16333 NCK1; NbExp=2; IntAct=EBI-1644065, EBI-389883; 
# IntAct	Q13796	5
# InterPro	IPR001478	PDZ
# InterPro	IPR014799	ASD2_dom
# InterPro	IPR014800	ASD1_dom
# InterPro	IPR027685	Shroom_fam
# MIM	300103	gene
# Organism	SHRM2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR15012	PTHR15012
# PDB	5F4Y	X-ray; 3.29 A; A/B=1427-1610
# PDB	5F5P	X-ray; 3.57 A; A/B/G/H=1427-1610
# PIR	I37183	I37183
# PROSITE	PS50106	PDZ
# PROSITE	PS51306	ASD1
# PROSITE	PS51307	ASD2
# Pfam	PF00595	PDZ
# Pfam	PF08687	ASD2
# Pfam	PF08688	ASD1
# Proteomes	UP000005640	Chromosome X
# RecName	SHRM2_HUMAN	Protein Shroom2
# RefSeq	NP_001307592	NM_001320663.1
# RefSeq	NP_001307593	NM_001320664.1
# RefSeq	NP_001640	NM_001649.3
# SIMILARITY	Belongs to the shroom family. {ECO	0000305}. 
# SIMILARITY	Contains 1 ASD1 domain. {ECO:0000255|PROSITE- ProRule	PRU00637}. 
# SIMILARITY	Contains 1 ASD2 domain. {ECO:0000255|PROSITE- ProRule	PRU00638}. 
# SIMILARITY	Contains 1 PDZ (DHR) domain. {ECO:0000255|PROSITE- ProRule	PRU00143}.
# SMART	SM00228	PDZ
# SUBCELLULAR LOCATION	SHRM2_HUMAN	Apical cell membrane {ECO 0000250}. Cell junction, tight junction {ECO 0000250}. Cytoplasm, cytoskeleton {ECO 0000250}. Note=Associates with cortical F-actin. {ECO 0000250}. 
# SUBUNIT	Interacts with F-actin. {ECO	0000250}. 
# SUPFAM	SSF50156	SSF50156
# TISSUE SPECIFICITY	SHRM2_HUMAN	Abundant in retina and melanoma; also in brain, placenta, lung, kidney and pancreas. 
# UCSC	uc004csu	human
# eggNOG	ENOG410II86	Eukaryota
# eggNOG	ENOG41113GY	LUCA
BLAST	swissprot:SHRM2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SHRM2_HUMAN
BioCyc	ZFISH:ENSG00000146950-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000146950-MONOMER
COXPRESdb	357	http://coxpresdb.jp/data/gene/357.shtml
CleanEx	HS_SHROOM2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SHROOM2
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1093/hmg/4.3.373	http://dx.doi.org/10.1093/hmg/4.3.373
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1186/1471-2121-7-18	http://dx.doi.org/10.1186/1471-2121-7-18
EMBL	AC002365	http://www.ebi.ac.uk/ena/data/view/AC002365
EMBL	AC090481	http://www.ebi.ac.uk/ena/data/view/AC090481
EMBL	BC140866	http://www.ebi.ac.uk/ena/data/view/BC140866
EMBL	X83543	http://www.ebi.ac.uk/ena/data/view/X83543
Ensembl	ENST00000380913	http://www.ensembl.org/id/ENST00000380913
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856
GO_component	GO:0005874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005874
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005913
GO_component	GO:0005923	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005923
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0003779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003779
GO_function	GO:0008013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008013
GO_function	GO:0015280	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015280
GO_function	GO:0051015	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051015
GO_process	GO:0002089	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002089
GO_process	GO:0007420	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007420
GO_process	GO:0008057	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008057
GO_process	GO:0016477	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016477
GO_process	GO:0032401	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032401
GO_process	GO:0032438	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032438
GO_process	GO:0043010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043010
GO_process	GO:0043482	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043482
GO_process	GO:0043583	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043583
GO_process	GO:0045176	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045176
GO_process	GO:0048593	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048593
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0043473	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043473
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
Gene3D	2.30.42.10	http://www.cathdb.info/version/latest/superfamily/2.30.42.10
GeneCards	SHROOM2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SHROOM2
GeneID	357	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=357
GeneTree	ENSGT00530000063061	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063061
HGNC	HGNC:630	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:630
HOGENOM	HOG000008235	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000008235&db=HOGENOM6
HOVERGEN	HBG096290	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG096290&db=HOVERGEN
HPA	HPA051646	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA051646
InParanoid	Q13796	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q13796
IntAct	Q13796	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q13796*
InterPro	IPR001478	http://www.ebi.ac.uk/interpro/entry/IPR001478
InterPro	IPR014799	http://www.ebi.ac.uk/interpro/entry/IPR014799
InterPro	IPR014800	http://www.ebi.ac.uk/interpro/entry/IPR014800
InterPro	IPR027685	http://www.ebi.ac.uk/interpro/entry/IPR027685
Jabion	357	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=357
KEGG_Gene	hsa:357	http://www.genome.jp/dbget-bin/www_bget?hsa:357
MIM	300103	http://www.ncbi.nlm.nih.gov/omim/300103
OMA	WKEQRKP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WKEQRKP
OrthoDB	EOG091G00F1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00F1
PANTHER	PTHR15012	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15012
PDB	5F4Y	http://www.ebi.ac.uk/pdbe-srv/view/entry/5F4Y
PDB	5F5P	http://www.ebi.ac.uk/pdbe-srv/view/entry/5F5P
PDBsum	5F4Y	http://www.ebi.ac.uk/pdbsum/5F4Y
PDBsum	5F5P	http://www.ebi.ac.uk/pdbsum/5F5P
PROSITE	PS50106	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50106
PROSITE	PS51306	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51306
PROSITE	PS51307	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51307
PSORT	swissprot:SHRM2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SHRM2_HUMAN
PSORT-B	swissprot:SHRM2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SHRM2_HUMAN
PSORT2	swissprot:SHRM2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SHRM2_HUMAN
Pfam	PF00595	http://pfam.xfam.org/family/PF00595
Pfam	PF08687	http://pfam.xfam.org/family/PF08687
Pfam	PF08688	http://pfam.xfam.org/family/PF08688
PharmGKB	PA24916	http://www.pharmgkb.org/do/serve?objId=PA24916&objCls=Gene
Phobius	swissprot:SHRM2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SHRM2_HUMAN
PhylomeDB	Q13796	http://phylomedb.org/?seqid=Q13796
ProteinModelPortal	Q13796	http://www.proteinmodelportal.org/query/uniprot/Q13796
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	16615870	http://www.ncbi.nlm.nih.gov/pubmed/16615870
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	7795590	http://www.ncbi.nlm.nih.gov/pubmed/7795590
RefSeq	NP_001307592	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001307592
RefSeq	NP_001307593	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001307593
RefSeq	NP_001640	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001640
SMART	SM00228	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00228
SMR	Q13796	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q13796
STRING	9606.ENSP00000370299	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000370299&targetmode=cogs
SUPFAM	SSF50156	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50156
UCSC	uc004csu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004csu&org=rat
UniGene	Hs.567236	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.567236
UniProtKB	SHRM2_HUMAN	http://www.uniprot.org/uniprot/SHRM2_HUMAN
UniProtKB-AC	Q13796	http://www.uniprot.org/uniprot/Q13796
charge	swissprot:SHRM2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SHRM2_HUMAN
eggNOG	ENOG410II86	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410II86
eggNOG	ENOG41113GY	http://eggnogapi.embl.de/nog_data/html/tree/ENOG41113GY
epestfind	swissprot:SHRM2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SHRM2_HUMAN
garnier	swissprot:SHRM2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SHRM2_HUMAN
helixturnhelix	swissprot:SHRM2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SHRM2_HUMAN
hmoment	swissprot:SHRM2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SHRM2_HUMAN
iep	swissprot:SHRM2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SHRM2_HUMAN
inforesidue	swissprot:SHRM2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SHRM2_HUMAN
neXtProt	NX_Q13796	http://www.nextprot.org/db/entry/NX_Q13796
octanol	swissprot:SHRM2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SHRM2_HUMAN
pepcoil	swissprot:SHRM2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SHRM2_HUMAN
pepdigest	swissprot:SHRM2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SHRM2_HUMAN
pepinfo	swissprot:SHRM2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SHRM2_HUMAN
pepnet	swissprot:SHRM2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SHRM2_HUMAN
pepstats	swissprot:SHRM2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SHRM2_HUMAN
pepwheel	swissprot:SHRM2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SHRM2_HUMAN
pepwindow	swissprot:SHRM2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SHRM2_HUMAN
sigcleave	swissprot:SHRM2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SHRM2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNK2_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=TREK-1b; IsoId=O95069-1; Sequence=Displayed; Name=2; Synonyms=TREK-1a; IsoId=O95069-2; Sequence=VSP_024429; Name=3; Synonyms=TREK-1c; IsoId=O95069-3; Sequence=VSP_024428; Name=4; Synonyms=TREK-1e; IsoId=O95069-4; Sequence=VSP_024428, VSP_047567, VSP_047568; 
# AltName	KCNK2_HUMAN	Outward rectifying potassium channel protein TREK-1
# AltName	KCNK2_HUMAN	TREK-1 K(+) channel subunit
# AltName	KCNK2_HUMAN	Two pore domain potassium channel TREK-1
# AltName	KCNK2_HUMAN	Two pore potassium channel TPKC1
# CCDS	CCDS31024	-. [O95069-2]
# CCDS	CCDS41466	-. [O95069-3]
# CCDS	CCDS41467	-. [O95069-1]
# ChiTaRS	KCNK2	human
# DOMAIN	KCNK2_HUMAN	The C-terminal region of isoform 4 mediates its intracellular retention. {ECO 0000250}. 
# DrugBank	DB00204	Dofetilide
# DrugBank	DB04855	Dronedarone
# Ensembl	ENST00000391894	ENSP00000375764; ENSG00000082482. [O95069-2]
# Ensembl	ENST00000391895	ENSP00000375765; ENSG00000082482. [O95069-3]
# Ensembl	ENST00000444842	ENSP00000394033; ENSG00000082482. [O95069-1]
# Ensembl	ENST00000467031	ENSP00000420203; ENSG00000082482. [O95069-4]
# ExpressionAtlas	O95069	baseline and differential
# FUNCTION	KCNK2_HUMAN	Ion channel that contributes to passive transmembrane potassium transport (PubMed 23169818). Reversibly converts between a voltage-insensitive potassium leak channel and a voltage- dependent outward rectifying potassium channel in a phosphorylation-dependent manner (PubMed 11319556). In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity). {ECO 0000250|UniProtKB P97438, ECO 0000269|PubMed 10784345, ECO 0000269|PubMed 11319556, ECO 0000269|PubMed 23169818}. 
# FUNCTION	KCNK2_HUMAN	Isoform 4  Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2. {ECO 0000250}. 
# GO_component	GO:0005634	nucleus; IEA:Ensembl.
# GO_component	GO:0005783	endoplasmic reticulum; ISS:UniProtKB.
# GO_component	GO:0005789	endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; ISS:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IEA:Ensembl.
# GO_component	GO:0009986	cell surface; IEA:Ensembl.
# GO_component	GO:0016324	apical plasma membrane; IEA:Ensembl.
# GO_component	GO:0043025	neuronal cell body; IEA:Ensembl.
# GO_component	GO:0044305	calyx of Held; IEA:Ensembl.
# GO_component	GO:0097449	astrocyte projection; IEA:Ensembl.
# GO_function	GO:0015271	outward rectifier potassium channel activity; ISS:UniProtKB.
# GO_function	GO:0019870	potassium channel inhibitor activity; ISS:UniProtKB.
# GO_function	GO:0022841	potassium ion leak channel activity; ISS:UniProtKB.
# GO_process	GO:0003231	cardiac ventricle development; IEA:Ensembl.
# GO_process	GO:0007186	G-protein coupled receptor signaling pathway; IEA:Ensembl.
# GO_process	GO:0007613	memory; IEA:Ensembl.
# GO_process	GO:0009612	response to mechanical stimulus; IEA:Ensembl.
# GO_process	GO:0010942	positive regulation of cell death; IEA:Ensembl.
# GO_process	GO:0030322	stabilization of membrane potential; IBA:GO_Central.
# GO_process	GO:0048678	response to axon injury; IEA:Ensembl.
# GO_process	GO:0060044	negative regulation of cardiac muscle cell proliferation; IEA:Ensembl.
# GO_process	GO:0071456	cellular response to hypoxia; IEA:Ensembl.
# GO_process	GO:0071805	potassium ion transmembrane transport; ISS:UniProtKB.
# GO_process	GO:0090102	cochlea development; IEA:Ensembl.
# GO_process	GO:1900039	positive regulation of cellular response to hypoxia; IEA:Ensembl.
# GO_process	GO:2000279	negative regulation of DNA biosynthetic process; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	O95069	HS
# HGNC	HGNC:6277	KCNK2
# InterPro	IPR003280	2pore_dom_K_chnl
# InterPro	IPR003976	2pore_dom_K_chnl_TREK
# InterPro	IPR013099	K_chnl_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04971	Gastric acid secretion
# MIM	603219	gene
# MISCELLANEOUS	KCNK2_HUMAN	Activated by volatile general anesthetics such as chloroform, halothane and isoflurane. 
# Organism	KCNK2_HUMAN	Homo sapiens (Human)
# PDB	4TWK	X-ray; 2.60 A; A/B=41-315
# PRINTS	PR01333	2POREKCHANEL
# PRINTS	PR01499	TREKCHANNEL
# PTM	KCNK2_HUMAN	Phosphorylation at Ser-348 controls the reversible conversion from a leak channel to a voltage-dependent channel. {ECO 0000269|PubMed 11319556}. 
# Pfam	PF07885	Ion_trans_2; 2
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-1299503	TWIK related potassium channel (TREK)
# Reactome	R-HSA-5576886	Phase 4 - resting membrane potential
# RecName	KCNK2_HUMAN	Potassium channel subfamily K member 2
# RefSeq	NP_001017424	NM_001017424.2. [O95069-3]
# RefSeq	NP_001017425	NM_001017425.2. [O95069-1]
# RefSeq	NP_055032	NM_014217.3. [O95069-2]
# RefSeq	XP_016856737	XM_017001248.1. [O95069-3]
# SIMILARITY	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCNK2_HUMAN	Isoform 1  Cell membrane {ECO 0000269|PubMed 23169818}; Multi-pass membrane protein {ECO 0000305}. 
# SUBCELLULAR LOCATION	KCNK2_HUMAN	Isoform 2  Cell membrane {ECO 0000269|PubMed 10784345}; Multi-pass membrane protein {ECO 0000305}. 
# SUBCELLULAR LOCATION	KCNK2_HUMAN	Isoform 4  Endoplasmic reticulum membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUBUNIT	KCNK2_HUMAN	Homodimer; disulfide-linked (Ref.13). Heterodimer with KCNK1; disulfide-linked (By similarity). Interacts with BVES; the interaction enhances KCNK2 surface expression and is inhibited by cAMP (PubMed 26642364). {ECO 0000250|UniProtKB P97438, ECO 0000269|PubMed 26642364, ECO 0000269|Ref.13}. 
# TISSUE SPECIFICITY	Isoform 4 is detected in kidney, adrenal gland and brain where it is preferentially expressed in the amygdala but not found in thalamus, hypothalamus, hippocampus or substantia nigra. {ECO:0000269|PubMed	24196565}. 
# UCSC	uc001hkq	human. [O95069-1]
# eggNOG	COG1226	LUCA
# eggNOG	KOG1418	Eukaryota
BLAST	swissprot:KCNK2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNK2_HUMAN
BioCyc	ZFISH:ENSG00000082482-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000082482-MONOMER
COXPRESdb	3776	http://coxpresdb.jp/data/gene/3776.shtml
CleanEx	HS_KCNK2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNK2
DOI	10.1007/s00424-013-1384-z	http://dx.doi.org/10.1007/s00424-013-1384-z
DOI	10.1007/s004249900235	http://dx.doi.org/10.1007/s004249900235
DOI	10.1038/8084	http://dx.doi.org/10.1038/8084
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2003431	http://dx.doi.org/10.1126/scisignal.2003431
DOI	10.1172/JCI79562	http://dx.doi.org/10.1172/JCI79562
DrugBank	DB00204	http://www.drugbank.ca/drugs/DB00204
DrugBank	DB04855	http://www.drugbank.ca/drugs/DB04855
EMBL	AC092804	http://www.ebi.ac.uk/ena/data/view/AC092804
EMBL	AC099675	http://www.ebi.ac.uk/ena/data/view/AC099675
EMBL	AF004711	http://www.ebi.ac.uk/ena/data/view/AF004711
EMBL	AF129399	http://www.ebi.ac.uk/ena/data/view/AF129399
EMBL	AF171068	http://www.ebi.ac.uk/ena/data/view/AF171068
EMBL	AK291483	http://www.ebi.ac.uk/ena/data/view/AK291483
EMBL	AK315249	http://www.ebi.ac.uk/ena/data/view/AK315249
EMBL	AL583830	http://www.ebi.ac.uk/ena/data/view/AL583830
EMBL	AY552980	http://www.ebi.ac.uk/ena/data/view/AY552980
EMBL	AY552981	http://www.ebi.ac.uk/ena/data/view/AY552981
EMBL	BC069462	http://www.ebi.ac.uk/ena/data/view/BC069462
EMBL	BC101693	http://www.ebi.ac.uk/ena/data/view/BC101693
EMBL	BC101695	http://www.ebi.ac.uk/ena/data/view/BC101695
EMBL	BC143586	http://www.ebi.ac.uk/ena/data/view/BC143586
EMBL	CH471100	http://www.ebi.ac.uk/ena/data/view/CH471100
EMBL	CH471100	http://www.ebi.ac.uk/ena/data/view/CH471100
EMBL	EF165334	http://www.ebi.ac.uk/ena/data/view/EF165334
EMBL	EF165335	http://www.ebi.ac.uk/ena/data/view/EF165335
Ensembl	ENST00000391894	http://www.ensembl.org/id/ENST00000391894
Ensembl	ENST00000391895	http://www.ensembl.org/id/ENST00000391895
Ensembl	ENST00000444842	http://www.ensembl.org/id/ENST00000444842
Ensembl	ENST00000467031	http://www.ensembl.org/id/ENST00000467031
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0044305	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044305
GO_component	GO:0097449	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097449
GO_function	GO:0015271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015271
GO_function	GO:0019870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019870
GO_function	GO:0022841	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022841
GO_process	GO:0003231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003231
GO_process	GO:0007186	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007186
GO_process	GO:0007613	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007613
GO_process	GO:0009612	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009612
GO_process	GO:0010942	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010942
GO_process	GO:0030322	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030322
GO_process	GO:0048678	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048678
GO_process	GO:0060044	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060044
GO_process	GO:0071456	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071456
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GO_process	GO:0090102	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090102
GO_process	GO:1900039	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900039
GO_process	GO:2000279	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000279
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	KCNK2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNK2
GeneID	3776	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3776
GeneTree	ENSGT00760000118858	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118858
HGNC	HGNC:6277	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6277
HOGENOM	HOG000137657	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000137657&db=HOGENOM6
HOVERGEN	HBG052234	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052234&db=HOVERGEN
HPA	HPA056054	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA056054
InParanoid	O95069	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O95069
InterPro	IPR003280	http://www.ebi.ac.uk/interpro/entry/IPR003280
InterPro	IPR003976	http://www.ebi.ac.uk/interpro/entry/IPR003976
InterPro	IPR013099	http://www.ebi.ac.uk/interpro/entry/IPR013099
Jabion	3776	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3776
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3776	http://www.genome.jp/dbget-bin/www_bget?hsa:3776
KEGG_Orthology	KO:K04913	http://www.genome.jp/dbget-bin/www_bget?KO:K04913
KEGG_Pathway	ko04971	http://www.genome.jp/kegg-bin/show_pathway?ko04971
MIM	603219	http://www.ncbi.nlm.nih.gov/omim/603219
OMA	AINVMKW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AINVMKW
OrthoDB	EOG091G0E3R	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0E3R
PDB	4TWK	http://www.ebi.ac.uk/pdbe-srv/view/entry/4TWK
PDBsum	4TWK	http://www.ebi.ac.uk/pdbsum/4TWK
PRINTS	PR01333	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01333
PRINTS	PR01499	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01499
PSORT	swissprot:KCNK2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNK2_HUMAN
PSORT-B	swissprot:KCNK2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNK2_HUMAN
PSORT2	swissprot:KCNK2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNK2_HUMAN
Pfam	PF07885	http://pfam.xfam.org/family/PF07885
PharmGKB	PA30059	http://www.pharmgkb.org/do/serve?objId=PA30059&objCls=Gene
Phobius	swissprot:KCNK2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNK2_HUMAN
PhylomeDB	O95069	http://phylomedb.org/?seqid=O95069
ProteinModelPortal	O95069	http://www.proteinmodelportal.org/query/uniprot/O95069
PubMed	10321245	http://www.ncbi.nlm.nih.gov/pubmed/10321245
PubMed	10784345	http://www.ncbi.nlm.nih.gov/pubmed/10784345
PubMed	11319556	http://www.ncbi.nlm.nih.gov/pubmed/11319556
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	23169818	http://www.ncbi.nlm.nih.gov/pubmed/23169818
PubMed	24196565	http://www.ncbi.nlm.nih.gov/pubmed/24196565
PubMed	26642364	http://www.ncbi.nlm.nih.gov/pubmed/26642364
Reactome	R-HSA-1299503	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1299503
Reactome	R-HSA-5576886	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576886
RefSeq	NP_001017424	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001017424
RefSeq	NP_001017425	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001017425
RefSeq	NP_055032	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055032
RefSeq	XP_016856737	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016856737
SMR	O95069	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O95069
STRING	9606.ENSP00000394033	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000394033&targetmode=cogs
UCSC	uc001hkq	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001hkq&org=rat
UniGene	Hs.497745	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.497745
UniProtKB	KCNK2_HUMAN	http://www.uniprot.org/uniprot/KCNK2_HUMAN
UniProtKB-AC	O95069	http://www.uniprot.org/uniprot/O95069
charge	swissprot:KCNK2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNK2_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG1418	http://eggnogapi.embl.de/nog_data/html/tree/KOG1418
epestfind	swissprot:KCNK2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNK2_HUMAN
garnier	swissprot:KCNK2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNK2_HUMAN
helixturnhelix	swissprot:KCNK2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNK2_HUMAN
hmoment	swissprot:KCNK2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNK2_HUMAN
iep	swissprot:KCNK2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNK2_HUMAN
inforesidue	swissprot:KCNK2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNK2_HUMAN
neXtProt	NX_O95069	http://www.nextprot.org/db/entry/NX_O95069
octanol	swissprot:KCNK2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNK2_HUMAN
pepcoil	swissprot:KCNK2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNK2_HUMAN
pepdigest	swissprot:KCNK2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNK2_HUMAN
pepinfo	swissprot:KCNK2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNK2_HUMAN
pepnet	swissprot:KCNK2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNK2_HUMAN
pepstats	swissprot:KCNK2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNK2_HUMAN
pepwheel	swissprot:KCNK2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNK2_HUMAN
pepwindow	swissprot:KCNK2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNK2_HUMAN
sigcleave	swissprot:KCNK2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNK2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	BEST3_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=2; IsoId=Q8N1M1-2; Sequence=Displayed; Name=1; IsoId=Q8N1M1-1; Sequence=VSP_008977, VSP_008978; Name=4; IsoId=Q8N1M1-4; Sequence=VSP_008981, VSP_008982, VSP_008983; Name=5; IsoId=Q8N1M1-5; Sequence=VSP_046979, VSP_046980; Note=Gene prediction based on EST data.; Name=6; IsoId=Q8N1M1-6; Sequence=VSP_008981; 
# AltName	BEST3_HUMAN	Vitelliform macular dystrophy 2-like protein 3
# CCDS	CCDS41810	-. [Q8N1M1-5]
# CCDS	CCDS61192	-. [Q8N1M1-6]
# CCDS	CCDS61193	-. [Q8N1M1-1]
# CCDS	CCDS73496	-. [Q8N1M1-4]
# CCDS	CCDS8992	-. [Q8N1M1-2]
# ChiTaRS	BEST3	human
# Ensembl	ENST00000266661	ENSP00000266661; ENSG00000127325. [Q8N1M1-4]
# Ensembl	ENST00000330891	ENSP00000332413; ENSG00000127325. [Q8N1M1-2]
# Ensembl	ENST00000331471	ENSP00000329064; ENSG00000127325. [Q8N1M1-1]
# Ensembl	ENST00000488961	ENSP00000433213; ENSG00000127325. [Q8N1M1-5]
# Ensembl	ENST00000551160	ENSP00000449377; ENSG00000127325. [Q8N1M1-4]
# Ensembl	ENST00000553096	ENSP00000449548; ENSG00000127325. [Q8N1M1-6]
# ExpressionAtlas	Q8N1M1	baseline and differential
# FUNCTION	BEST3_HUMAN	Forms calcium-sensitive chloride channels. Permeable to bicarbonate. {ECO 0000269|PubMed 12907679}. 
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0034707	chloride channel complex; IBA:GO_Central.
# GO_function	GO:0005254	chloride channel activity; IEA:UniProtKB-KW.
# GO_process	GO:0043271	negative regulation of ion transport; IEA:Ensembl.
# GO_process	GO:1902476	chloride transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q8N1M1	HS
# HGNC	HGNC:17105	BEST3
# InterPro	IPR000615	Bestrophin
# InterPro	IPR021134	Bestrophin/UPF0187
# KEGG_Brite	ko02000	Transporters
# MIM	607337	gene
# Organism	BEST3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10736	PTHR10736
# Pfam	PF01062	Bestrophin
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	BEST3_HUMAN	Bestrophin-3
# RefSeq	NP_001269542	NM_001282613.1. [Q8N1M1-6]
# RefSeq	NP_001269543	NM_001282614.1. [Q8N1M1-1]
# RefSeq	NP_001269544	NM_001282615.1. [Q8N1M1-4]
# RefSeq	NP_001269545	NM_001282616.1. [Q8N1M1-4]
# RefSeq	NP_116124	NM_032735.2. [Q8N1M1-2]
# RefSeq	NP_689652	NM_152439.3. [Q8N1M1-5]
# RefSeq	XP_011536263	XM_011537961.1. [Q8N1M1-6]
# SIMILARITY	Belongs to the bestrophin family. {ECO	0000305}.
# SUBCELLULAR LOCATION	BEST3_HUMAN	Cell membrane; Multi-pass membrane protein. 
# TISSUE SPECIFICITY	Present in skeletal muscle and weakly in brain, spinal cord, bone marrow and retina. {ECO:0000269|PubMed	12032738}. 
# UCSC	uc001svd	human. [Q8N1M1-2]
# eggNOG	ENOG410XS3J	LUCA
# eggNOG	KOG3547	Eukaryota
BLAST	swissprot:BEST3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:BEST3_HUMAN
COXPRESdb	144453	http://coxpresdb.jp/data/gene/144453.shtml
CleanEx	HS_BEST3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_BEST3
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.ejhg.5200796	http://dx.doi.org/10.1038/sj.ejhg.5200796
DOI	10.1074/jbc.M306150200	http://dx.doi.org/10.1074/jbc.M306150200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC016153	http://www.ebi.ac.uk/ena/data/view/AC016153
EMBL	AC018921	http://www.ebi.ac.uk/ena/data/view/AC018921
EMBL	AC025263	http://www.ebi.ac.uk/ena/data/view/AC025263
EMBL	AF440758	http://www.ebi.ac.uk/ena/data/view/AF440758
EMBL	AK096459	http://www.ebi.ac.uk/ena/data/view/AK096459
EMBL	AY515706	http://www.ebi.ac.uk/ena/data/view/AY515706
EMBL	BC006440	http://www.ebi.ac.uk/ena/data/view/BC006440
EMBL	BC151138	http://www.ebi.ac.uk/ena/data/view/BC151138
Ensembl	ENST00000266661	http://www.ensembl.org/id/ENST00000266661
Ensembl	ENST00000330891	http://www.ensembl.org/id/ENST00000330891
Ensembl	ENST00000331471	http://www.ensembl.org/id/ENST00000331471
Ensembl	ENST00000488961	http://www.ensembl.org/id/ENST00000488961
Ensembl	ENST00000551160	http://www.ensembl.org/id/ENST00000551160
Ensembl	ENST00000553096	http://www.ensembl.org/id/ENST00000553096
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_process	GO:0043271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043271
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	BEST3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=BEST3
GeneID	144453	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=144453
GeneTree	ENSGT00390000002997	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002997
H-InvDB	HIX0010809	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0010809
HGNC	HGNC:17105	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17105
HOGENOM	HOG000115678	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000115678&db=HOGENOM6
HOVERGEN	HBG080894	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG080894&db=HOVERGEN
HPA	HPA054582	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA054582
InParanoid	Q8N1M1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8N1M1
InterPro	IPR000615	http://www.ebi.ac.uk/interpro/entry/IPR000615
InterPro	IPR021134	http://www.ebi.ac.uk/interpro/entry/IPR021134
Jabion	144453	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=144453
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:144453	http://www.genome.jp/dbget-bin/www_bget?hsa:144453
KEGG_Orthology	KO:K13880	http://www.genome.jp/dbget-bin/www_bget?KO:K13880
MIM	607337	http://www.ncbi.nlm.nih.gov/omim/607337
OMA	KRFLSAH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KRFLSAH
OrthoDB	EOG091G06XO	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G06XO
PANTHER	PTHR10736	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10736
PSORT	swissprot:BEST3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:BEST3_HUMAN
PSORT-B	swissprot:BEST3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:BEST3_HUMAN
PSORT2	swissprot:BEST3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:BEST3_HUMAN
Pfam	PF01062	http://pfam.xfam.org/family/PF01062
PharmGKB	PA162377503	http://www.pharmgkb.org/do/serve?objId=PA162377503&objCls=Gene
Phobius	swissprot:BEST3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:BEST3_HUMAN
PhylomeDB	Q8N1M1	http://phylomedb.org/?seqid=Q8N1M1
ProteinModelPortal	Q8N1M1	http://www.proteinmodelportal.org/query/uniprot/Q8N1M1
PubMed	12032738	http://www.ncbi.nlm.nih.gov/pubmed/12032738
PubMed	12907679	http://www.ncbi.nlm.nih.gov/pubmed/12907679
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_001269542	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269542
RefSeq	NP_001269543	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269543
RefSeq	NP_001269544	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269544
RefSeq	NP_001269545	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269545
RefSeq	NP_116124	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_116124
RefSeq	NP_689652	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_689652
RefSeq	XP_011536263	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011536263
SMR	Q8N1M1	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8N1M1
STRING	9606.ENSP00000332413	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000332413&targetmode=cogs
UCSC	uc001svd	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001svd&org=rat
UniGene	Hs.280782	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.280782
UniProtKB	BEST3_HUMAN	http://www.uniprot.org/uniprot/BEST3_HUMAN
UniProtKB-AC	Q8N1M1	http://www.uniprot.org/uniprot/Q8N1M1
charge	swissprot:BEST3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:BEST3_HUMAN
eggNOG	ENOG410XS3J	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS3J
eggNOG	KOG3547	http://eggnogapi.embl.de/nog_data/html/tree/KOG3547
epestfind	swissprot:BEST3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:BEST3_HUMAN
garnier	swissprot:BEST3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:BEST3_HUMAN
helixturnhelix	swissprot:BEST3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:BEST3_HUMAN
hmoment	swissprot:BEST3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:BEST3_HUMAN
iep	swissprot:BEST3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:BEST3_HUMAN
inforesidue	swissprot:BEST3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:BEST3_HUMAN
neXtProt	NX_Q8N1M1	http://www.nextprot.org/db/entry/NX_Q8N1M1
octanol	swissprot:BEST3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:BEST3_HUMAN
pepcoil	swissprot:BEST3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:BEST3_HUMAN
pepdigest	swissprot:BEST3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:BEST3_HUMAN
pepinfo	swissprot:BEST3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:BEST3_HUMAN
pepnet	swissprot:BEST3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:BEST3_HUMAN
pepstats	swissprot:BEST3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:BEST3_HUMAN
pepwheel	swissprot:BEST3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:BEST3_HUMAN
pepwindow	swissprot:BEST3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:BEST3_HUMAN
sigcleave	swissprot:BEST3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:BEST3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	MMGT1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N4V1-1; Sequence=Displayed; Name=2; IsoId=Q8N4V1-2; Sequence=VSP_036488; Note=No experimental confirmation available.; 
# AltName	MMGT1_HUMAN	ER membrane protein complex subunit 5
# AltName	MMGT1_HUMAN	Transmembrane protein 32
# BioGrid	125021	117
# CCDS	CCDS14653	-. [Q8N4V1-1]
# ChiTaRS	MMGT1	human
# Ensembl	ENST00000305963	ENSP00000306220; ENSG00000169446. [Q8N4V1-1]
# FUNCTION	MMGT1_HUMAN	Mediates Mg(2+) transport. {ECO 0000250|UniProtKB Q8K273}. 
# GO_component	GO:0000139	Golgi membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005769	early endosome; ISS:UniProtKB.
# GO_component	GO:0005794	Golgi apparatus; ISS:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IDA:UniProtKB.
# GO_component	GO:0031901	early endosome membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0072546	ER membrane protein complex; IDA:UniProtKB.
# GO_function	GO:0015087	cobalt ion transmembrane transporter activity; IEA:Ensembl.
# GO_function	GO:0015093	ferrous iron transmembrane transporter activity; IEA:Ensembl.
# GO_function	GO:0015095	magnesium ion transmembrane transporter activity; ISS:UniProtKB.
# GO_function	GO:0022890	inorganic cation transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0006825	copper ion transport; IEA:Ensembl.
# GO_process	GO:0015693	magnesium ion transport; ISS:UniProtKB.
# GO_process	GO:0098655	cation transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q8N4V1	HS
# HGNC	HGNC:28100	MMGT1
# IntAct	Q8N4V1	102
# InterPro	IPR018937	Magnesium_transport
# Organism	MMGT1_HUMAN	Homo sapiens (Human)
# Pfam	PF10270	MMgT
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-5223345	Miscellaneous transport and binding events
# RecName	MMGT1_HUMAN	Membrane magnesium transporter 1
# RefSeq	NP_001316929	NM_001330000.1
# RefSeq	NP_775741	NM_173470.2. [Q8N4V1-1]
# SIMILARITY	Belongs to the membrane magnesium transporter (TC 1.A.67) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	MMGT1_HUMAN	Endoplasmic reticulum membrane {ECO 0000269|PubMed 22119785}; Multi-pass membrane protein {ECO 0000255}. Golgi apparatus membrane {ECO 0000250|UniProtKB Q8K273}; Multi-pass membrane protein {ECO 0000255}. Early endosome membrane {ECO 0000250|UniProtKB Q8K273}; Multi-pass membrane protein {ECO 0000255}. 
# SUBUNIT	Component of the ER membrane protein complex (EMC). {ECO:0000269|PubMed	22119785}. 
# TopDownProteomics	Q8N4V1-1	-. [Q8N4V1-1]
# UCSC	uc004ezi	human. [Q8N4V1-1]
# eggNOG	ENOG4111TZW	LUCA
# eggNOG	KOG3918	Eukaryota
BLAST	swissprot:MMGT1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MMGT1_HUMAN
BioCyc	ZFISH:ENSG00000169446-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000169446-MONOMER
COXPRESdb	93380	http://coxpresdb.jp/data/gene/93380.shtml
CleanEx	HS_MMGT1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_MMGT1
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1038/ncb2383	http://dx.doi.org/10.1038/ncb2383
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AK295829	http://www.ebi.ac.uk/ena/data/view/AK295829
EMBL	AK312409	http://www.ebi.ac.uk/ena/data/view/AK312409
EMBL	AL732579	http://www.ebi.ac.uk/ena/data/view/AL732579
EMBL	AL953870	http://www.ebi.ac.uk/ena/data/view/AL953870
EMBL	BC033588	http://www.ebi.ac.uk/ena/data/view/BC033588
EMBL	CH471150	http://www.ebi.ac.uk/ena/data/view/CH471150
EMBL	CH471150	http://www.ebi.ac.uk/ena/data/view/CH471150
Ensembl	ENST00000305963	http://www.ensembl.org/id/ENST00000305963
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005769	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005769
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0031901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031901
GO_component	GO:0072546	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072546
GO_function	GO:0015087	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015087
GO_function	GO:0015093	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015093
GO_function	GO:0015095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015095
GO_function	GO:0022890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022890
GO_process	GO:0006825	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006825
GO_process	GO:0015693	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015693
GO_process	GO:0098655	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098655
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	MMGT1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=MMGT1
GeneID	93380	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=93380
GeneTree	ENSGT00510000047104	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00510000047104
HGNC	HGNC:28100	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:28100
HOGENOM	HOG000244123	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000244123&db=HOGENOM6
HOVERGEN	HBG105215	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG105215&db=HOVERGEN
HPA	HPA032037	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA032037
InParanoid	Q8N4V1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8N4V1
IntAct	Q8N4V1	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8N4V1*
InterPro	IPR018937	http://www.ebi.ac.uk/interpro/entry/IPR018937
Jabion	93380	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=93380
KEGG_Gene	hsa:93380	http://www.genome.jp/dbget-bin/www_bget?hsa:93380
OMA	MAFAVTC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MAFAVTC
OrthoDB	EOG091G0Y35	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0Y35
PSORT	swissprot:MMGT1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MMGT1_HUMAN
PSORT-B	swissprot:MMGT1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MMGT1_HUMAN
PSORT2	swissprot:MMGT1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MMGT1_HUMAN
Pfam	PF10270	http://pfam.xfam.org/family/PF10270
PharmGKB	PA164723074	http://www.pharmgkb.org/do/serve?objId=PA164723074&objCls=Gene
Phobius	swissprot:MMGT1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MMGT1_HUMAN
PhylomeDB	Q8N4V1	http://phylomedb.org/?seqid=Q8N4V1
ProteinModelPortal	Q8N4V1	http://www.proteinmodelportal.org/query/uniprot/Q8N4V1
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22119785	http://www.ncbi.nlm.nih.gov/pubmed/22119785
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-5223345	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5223345
RefSeq	NP_001316929	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001316929
RefSeq	NP_775741	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_775741
STRING	9606.ENSP00000306220	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000306220&targetmode=cogs
UCSC	uc004ezi	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004ezi&org=rat
UniGene	Hs.110702	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.110702
UniProtKB	MMGT1_HUMAN	http://www.uniprot.org/uniprot/MMGT1_HUMAN
UniProtKB-AC	Q8N4V1	http://www.uniprot.org/uniprot/Q8N4V1
charge	swissprot:MMGT1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MMGT1_HUMAN
eggNOG	ENOG4111TZW	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111TZW
eggNOG	KOG3918	http://eggnogapi.embl.de/nog_data/html/tree/KOG3918
epestfind	swissprot:MMGT1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MMGT1_HUMAN
garnier	swissprot:MMGT1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MMGT1_HUMAN
helixturnhelix	swissprot:MMGT1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MMGT1_HUMAN
hmoment	swissprot:MMGT1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MMGT1_HUMAN
iep	swissprot:MMGT1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MMGT1_HUMAN
inforesidue	swissprot:MMGT1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MMGT1_HUMAN
neXtProt	NX_Q8N4V1	http://www.nextprot.org/db/entry/NX_Q8N4V1
octanol	swissprot:MMGT1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MMGT1_HUMAN
pepcoil	swissprot:MMGT1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MMGT1_HUMAN
pepdigest	swissprot:MMGT1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MMGT1_HUMAN
pepinfo	swissprot:MMGT1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MMGT1_HUMAN
pepnet	swissprot:MMGT1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MMGT1_HUMAN
pepstats	swissprot:MMGT1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MMGT1_HUMAN
pepwheel	swissprot:MMGT1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MMGT1_HUMAN
pepwindow	swissprot:MMGT1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MMGT1_HUMAN
sigcleave	swissprot:MMGT1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MMGT1_HUMAN
## Database	ID	URL or Descriptions
# AltName	PK1L3_HUMAN	PC1-like 3 protein
# AltName	PK1L3_HUMAN	Polycystin-1L3
# CAUTION	PK1L3_HUMAN	PKD1L3 and PKD2L1 have been defined as sour taste receptor in gustatory cells based on a number of indirect evidences in mouse. Some data confirm this hypothesis in human  in 2 patients with sour ageusia that are unresponsive to sour stimuli, but show normal responses to bitter, sweet, and salty stimuli, expression of PKD1L3 and PKD2L1 is absent in the anterior part of the tongue (PubMed 19812697). However, a number of experiments have recently shown that the sour taste receptor activity is probably indirect. {ECO 0000305|PubMed 19812697}.
# ENZYME REGULATION	PK1L3_HUMAN	The calcium channel is gated following an off- response property by acid  gated open after the removal of acid stimulus, but not during acid application. {ECO 0000269|PubMed 18535624, ECO 0000269|PubMed 19464260, ECO 0000269|PubMed 22420714}. 
# Ensembl	ENST00000620267	ENSP00000480090; ENSG00000277481
# FUNCTION	PK1L3_HUMAN	Component of a calcium channel. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect. {ECO 0000269|PubMed 12782129, ECO 0000269|PubMed 19812697, ECO 0000269|PubMed 23212381}. 
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0009986	cell surface; IEA:Ensembl.
# GO_component	GO:0034703	cation channel complex; ISS:BHF-UCL.
# GO_component	GO:0043235	receptor complex; ISS:BHF-UCL.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005262	calcium channel activity; IBA:GO_Central.
# GO_function	GO:0030246	carbohydrate binding; IEA:UniProtKB-KW.
# GO_process	GO:0001581	detection of chemical stimulus involved in sensory perception of sour taste; ISS:BHF-UCL.
# GO_process	GO:0001822	kidney development; IEA:InterPro.
# GO_process	GO:0006812	cation transport; ISS:BHF-UCL.
# GO_process	GO:0050915	sensory perception of sour taste; IMP:UniProtKB.
# GO_process	GO:0050982	detection of mechanical stimulus; IBA:GO_Central.
# GO_process	GO:0071468	cellular response to acidic pH; ISS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# Gene3D	2.60.60.20	-; 1.
# Gene3D	3.10.100.10	-; 1.
# HGNC	HGNC:21716	PKD1L3
# InterPro	IPR000203	GPS
# InterPro	IPR000434	PC1
# InterPro	IPR001024	PLAT/LH2_dom
# InterPro	IPR001304	C-type_lectin-like
# InterPro	IPR013122	PKD1_2_channel
# InterPro	IPR016186	C-type_lectin-like/link
# InterPro	IPR016187	CTDL_fold
# KEGG_Brite	ko04040	Ion channels
# MIM	607895	gene
# Organism	PK1L3_HUMAN	Homo sapiens (Human)
# PRINTS	PR00500	POLYCYSTIN1
# PROSITE	PS50095	PLAT
# PROSITE	PS50221	GPS
# Pfam	PF00059	Lectin_C
# Pfam	PF01477	PLAT
# Pfam	PF01825	GPS
# Pfam	PF08016	PKD_channel
# Proteomes	UP000005640	Chromosome 16
# RecName	PK1L3_HUMAN	Polycystic kidney disease protein 1-like 3
# RefSeq	NP_853514	NM_181536.1
# SIMILARITY	Belongs to the polycystin family. {ECO	0000305}. 
# SIMILARITY	Contains 1 C-type lectin domain. {ECO	0000305}. 
# SIMILARITY	Contains 1 GPS domain. {ECO:0000255|PROSITE- ProRule	PRU00098}. 
# SIMILARITY	Contains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule	PRU00152}. 
# SMART	SM00303	GPS
# SMART	SM00308	LH2
# SUBCELLULAR LOCATION	PK1L3_HUMAN	Cell membrane {ECO 0000269|PubMed 18535624, ECO 0000269|PubMed 20538909, ECO 0000269|PubMed 23212381}; Multi- pass membrane protein {ECO 0000269|PubMed 18535624, ECO 0000269|PubMed 20538909, ECO 0000269|PubMed 23212381}. Note=Interaction with PKD2L1 is required for localization to the cell membrane. 
# SUBUNIT	PK1L3_HUMAN	Calcium channels are probably composed of 3 subunit of PKD2L1 and 1 subunit of PKD1L3. 
# SUPFAM	SSF49723	SSF49723
# SUPFAM	SSF56436	SSF56436
# TCDB	1.A.5.1	the polycystin cation channel (pcc) family
# TISSUE SPECIFICITY	Highly expressed in placenta, weakly in heart and lung. {ECO:0000269|PubMed	12782129}. 
# UCSC	uc059wxm	human
BLAST	swissprot:PK1L3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:PK1L3_HUMAN
BioCyc	ZFISH:G66-32457-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32457-MONOMER
COXPRESdb	342372	http://coxpresdb.jp/data/gene/342372.shtml
CleanEx	HS_PKD1L3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_PKD1L3
DOI	10.1016/S0888-7543(03)00048-X	http://dx.doi.org/10.1016/S0888-7543(03)00048-X
DOI	10.1016/j.bbrc.2009.05.069	http://dx.doi.org/10.1016/j.bbrc.2009.05.069
DOI	10.1038/embor.2008.89	http://dx.doi.org/10.1038/embor.2008.89
DOI	10.1038/ncomms2257	http://dx.doi.org/10.1038/ncomms2257
DOI	10.1096/fj.10-162925	http://dx.doi.org/10.1096/fj.10-162925
DOI	10.1111/j.1742-4658.2012.08566.x	http://dx.doi.org/10.1111/j.1742-4658.2012.08566.x
DOI	10.1371/journal.pone.0007347	http://dx.doi.org/10.1371/journal.pone.0007347
EMBL	AY164485	http://www.ebi.ac.uk/ena/data/view/AY164485
Ensembl	ENST00000620267	http://www.ensembl.org/id/ENST00000620267
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0034703	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034703
GO_component	GO:0043235	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043235
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0030246	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030246
GO_process	GO:0001581	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001581
GO_process	GO:0001822	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001822
GO_process	GO:0006812	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006812
GO_process	GO:0050915	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050915
GO_process	GO:0050982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050982
GO_process	GO:0071468	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071468
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
Gene3D	2.60.60.20	http://www.cathdb.info/version/latest/superfamily/2.60.60.20
Gene3D	3.10.100.10	http://www.cathdb.info/version/latest/superfamily/3.10.100.10
GeneCards	PKD1L3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=PKD1L3
GeneID	342372	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=342372
GeneTree	ENSGT00700000104221	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00700000104221
H-InvDB	HIX0038832	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0038832
HGNC	HGNC:21716	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:21716
HOGENOM	HOG000230856	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230856&db=HOGENOM6
HOVERGEN	HBG066396	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG066396&db=HOVERGEN
InParanoid	Q7Z443	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q7Z443
IntAct	Q7Z443	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q7Z443*
InterPro	IPR000203	http://www.ebi.ac.uk/interpro/entry/IPR000203
InterPro	IPR000434	http://www.ebi.ac.uk/interpro/entry/IPR000434
InterPro	IPR001024	http://www.ebi.ac.uk/interpro/entry/IPR001024
InterPro	IPR001304	http://www.ebi.ac.uk/interpro/entry/IPR001304
InterPro	IPR013122	http://www.ebi.ac.uk/interpro/entry/IPR013122
InterPro	IPR016186	http://www.ebi.ac.uk/interpro/entry/IPR016186
InterPro	IPR016187	http://www.ebi.ac.uk/interpro/entry/IPR016187
Jabion	342372	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=342372
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:342372	http://www.genome.jp/dbget-bin/www_bget?hsa:342372
KEGG_Orthology	KO:K04989	http://www.genome.jp/dbget-bin/www_bget?KO:K04989
MIM	607895	http://www.ncbi.nlm.nih.gov/omim/607895
MINT	MINT-6743423	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6743423
OMA	AKCSSSV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AKCSSSV
OrthoDB	EOG091G004D	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G004D
PRINTS	PR00500	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00500
PROSITE	PS50095	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50095
PROSITE	PS50221	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50221
PSORT	swissprot:PK1L3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:PK1L3_HUMAN
PSORT-B	swissprot:PK1L3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:PK1L3_HUMAN
PSORT2	swissprot:PK1L3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:PK1L3_HUMAN
Pfam	PF00059	http://pfam.xfam.org/family/PF00059
Pfam	PF01477	http://pfam.xfam.org/family/PF01477
Pfam	PF01825	http://pfam.xfam.org/family/PF01825
Pfam	PF08016	http://pfam.xfam.org/family/PF08016
Phobius	swissprot:PK1L3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:PK1L3_HUMAN
PhylomeDB	Q7Z443	http://phylomedb.org/?seqid=Q7Z443
ProteinModelPortal	Q7Z443	http://www.proteinmodelportal.org/query/uniprot/Q7Z443
PubMed	12782129	http://www.ncbi.nlm.nih.gov/pubmed/12782129
PubMed	18535624	http://www.ncbi.nlm.nih.gov/pubmed/18535624
PubMed	19464260	http://www.ncbi.nlm.nih.gov/pubmed/19464260
PubMed	19812697	http://www.ncbi.nlm.nih.gov/pubmed/19812697
PubMed	20538909	http://www.ncbi.nlm.nih.gov/pubmed/20538909
PubMed	22420714	http://www.ncbi.nlm.nih.gov/pubmed/22420714
PubMed	23212381	http://www.ncbi.nlm.nih.gov/pubmed/23212381
RefSeq	NP_853514	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_853514
SMART	SM00303	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00303
SMART	SM00308	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00308
SMR	Q7Z443	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q7Z443
SUPFAM	SSF49723	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49723
SUPFAM	SSF56436	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56436
TCDB	1.A.5.1	http://www.tcdb.org/search/result.php?tc=1.A.5.1
UCSC	uc059wxm	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc059wxm&org=rat
UniGene	Hs.675286	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.675286
UniProtKB	PK1L3_HUMAN	http://www.uniprot.org/uniprot/PK1L3_HUMAN
UniProtKB-AC	Q7Z443	http://www.uniprot.org/uniprot/Q7Z443
charge	swissprot:PK1L3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:PK1L3_HUMAN
epestfind	swissprot:PK1L3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:PK1L3_HUMAN
garnier	swissprot:PK1L3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:PK1L3_HUMAN
helixturnhelix	swissprot:PK1L3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:PK1L3_HUMAN
hmoment	swissprot:PK1L3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:PK1L3_HUMAN
iep	swissprot:PK1L3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:PK1L3_HUMAN
inforesidue	swissprot:PK1L3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:PK1L3_HUMAN
neXtProt	NX_Q7Z443	http://www.nextprot.org/db/entry/NX_Q7Z443
octanol	swissprot:PK1L3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:PK1L3_HUMAN
pepcoil	swissprot:PK1L3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:PK1L3_HUMAN
pepdigest	swissprot:PK1L3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:PK1L3_HUMAN
pepinfo	swissprot:PK1L3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:PK1L3_HUMAN
pepnet	swissprot:PK1L3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:PK1L3_HUMAN
pepstats	swissprot:PK1L3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:PK1L3_HUMAN
pepwheel	swissprot:PK1L3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:PK1L3_HUMAN
pepwindow	swissprot:PK1L3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:PK1L3_HUMAN
sigcleave	swissprot:PK1L3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:PK1L3_HUMAN
## Database	ID	URL or Descriptions
# AltName	VPP2_HUMAN	Lysosomal H(+)-transporting ATPase V0 subunit a2
# AltName	VPP2_HUMAN	TJ6
# AltName	VPP2_HUMAN	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2
# BRENDA	3.6.3	2681
# BioGrid	117089	55
# CAUTION	The N-terminal peptide may increase IL1B secretion by peripheral blood monocytes; however as this region is probably in the cytosol, the in vivo relevance of this observation needs to be confirmed. {ECO	0000305}.
# ChiTaRS	ATP6V0A2	human
# DISEASE	VPP2_HUMAN	Cutis laxa, autosomal recessive, 2A (ARCL2A) [MIM 219200]  A disorder characterized by an excessive congenital skin wrinkling, a large fontanelle with delayed closure, a typical facial appearance with downslanting palpebral fissures, a general connective tissue weakness, and varying degrees of growth and developmental delay and neurological abnormalities. Some affected individuals develop seizures and mental deterioration later in life, whereas the skin phenotype tends to become milder with age. At the molecular level, an abnormal glycosylation of serum proteins is observed in many cases. {ECO 0000269|PubMed 18157129}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	VPP2_HUMAN	Wrinkly skin syndrome (WSS) [MIM 278250]  A rare autosomal recessive disorder characterized by wrinkling of the skin of the dorsum of the hands and feet, an increased number of palmar and plantar creases, wrinkled abdominal skin, multiple musculoskeletal abnormalities, microcephaly, growth failure and developmental delay. {ECO 0000269|PubMed 18157129}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000330342	ENSP00000332247; ENSG00000185344
# ExpressionAtlas	Q9Y487	baseline and differential
# FUNCTION	VPP2_HUMAN	Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH. {ECO 0000269|PubMed 16415858, ECO 0000269|PubMed 18157129}. 
# GO_component	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
# GO_component	GO:0001669	acrosomal vesicle; IEA:Ensembl.
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:HPA.
# GO_component	GO:0005925	focal adhesion; IDA:HPA.
# GO_component	GO:0010008	endosome membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0016471	vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
# GO_component	GO:0030670	phagocytic vesicle membrane; TAS:Reactome.
# GO_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
# GO_function	GO:0051117	ATPase binding; IBA:GO_Central.
# GO_process	GO:0006955	immune response; TAS:ProtInc.
# GO_process	GO:0007035	vacuolar acidification; IBA:GO_Central.
# GO_process	GO:0008286	insulin receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0015986	ATP synthesis coupled proton transport; IBA:GO_Central.
# GO_process	GO:0015991	ATP hydrolysis coupled proton transport; IEA:InterPro.
# GO_process	GO:0016241	regulation of macroautophagy; NAS:ParkinsonsUK-UCL.
# GO_process	GO:0033572	transferrin transport; TAS:Reactome.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
# GO_process	GO:0090383	phagosome acidification; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9Y487	HS
# HGNC	HGNC:18481	ATP6V0A2
# INTERACTION	VPP2_HUMAN	Q99418 CYTH2; NbExp=2; IntAct=EBI-988630, EBI-448974; 
# IntAct	Q9Y487	5
# InterPro	IPR002490	V-ATPase_116kDa_su
# InterPro	IPR026028	V-type_ATPase_116kDa_su_euka
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Disease	H00557	[Developmental disorder; Skin and connective tissue disease] Wrinkly skin syndrome
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04142	Lysosome
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04966	Collecting duct acid secretion
# KEGG_Pathway	ko05110	Vibrio cholerae infection
# KEGG_Pathway	ko05120	Epithelial cell signaling in Helicobacter pylori infection
# KEGG_Pathway	ko05152	Tuberculosis
# KEGG_Pathway	ko05323	Rheumatoid arthritis
# MIM	219200	phenotype
# MIM	278250	phenotype
# MIM	611716	gene
# Organism	VPP2_HUMAN	Homo sapiens (Human)
# Orphanet	2834	Wrinkly skin syndrome
# Orphanet	357074	Autosomal recessive cutis laxa type 2, classic type
# PANTHER	PTHR11629	PTHR11629
# PIRSF	PIRSF001293	ATP6V0A1
# Pfam	PF01496	V_ATPase_I
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-1222556	ROS, RNS production in response to bacteria
# Reactome	R-HSA-77387	Insulin receptor recycling
# Reactome	R-HSA-917977	Transferrin endocytosis and recycling
# Reactome	R-HSA-983712	Ion channel transport
# RecName	VPP2_HUMAN	V-type proton ATPase 116 kDa subunit a isoform 2
# RefSeq	NP_036595	NM_012463.3
# SIMILARITY	Belongs to the V-ATPase 116 kDa subunit family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	VPP2_HUMAN	Cell membrane; Multi-pass membrane protein. Endosome membrane. Note=In kidney proximal tubules, also detected in subapical vesicles. {ECO 0000250}. 
# SUBUNIT	The V-ATPase is a heteromultimeric enzyme composed of at least thirteen different subunits. It has a membrane peripheral V1 sector for ATP hydrolysis and an integral V0 for proton translocation. The V1 sector comprises subunits A-H, whereas V0 includes subunits a, d, c, c', and c''. Directly interacts with PSCD2 through its N-terminal cytosolic tail in an intra-endosomal acidification-dependent manner. Disruption of this interaction results in the inhibition of endocytosis. {ECO:0000269|PubMed	16415858}. 
# UCSC	uc001ufr	human
# eggNOG	COG1269	LUCA
# eggNOG	KOG2189	Eukaryota
BLAST	swissprot:VPP2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VPP2_HUMAN
BioCyc	MetaCyc:G66-33375-MONOMER	http://biocyc.org/getid?id=MetaCyc:G66-33375-MONOMER
BioCyc	ZFISH:G66-33375-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33375-MONOMER
COG	COG1269	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1269
COXPRESdb	23545	http://coxpresdb.jp/data/gene/23545.shtml
CleanEx	HS_ATP6V0A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP6V0A2
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/ncb1348	http://dx.doi.org/10.1038/ncb1348
DOI	10.1038/ng.2007.45	http://dx.doi.org/10.1038/ng.2007.45
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1600-0897.2006.00463.x	http://dx.doi.org/10.1111/j.1600-0897.2006.00463.x
DOI	10.1126/science.1140321	http://dx.doi.org/10.1126/science.1140321
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF112972	http://www.ebi.ac.uk/ena/data/view/AF112972
EMBL	AK289391	http://www.ebi.ac.uk/ena/data/view/AK289391
EMBL	BC068531	http://www.ebi.ac.uk/ena/data/view/BC068531
EMBL	CH471054	http://www.ebi.ac.uk/ena/data/view/CH471054
Ensembl	ENST00000330342	http://www.ensembl.org/id/ENST00000330342
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000220
GO_component	GO:0001669	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001669
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005925	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005925
GO_component	GO:0010008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010008
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016471
GO_component	GO:0030670	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030670
GO_function	GO:0046961	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046961
GO_function	GO:0051117	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051117
GO_process	GO:0006955	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006955
GO_process	GO:0007035	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007035
GO_process	GO:0008286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008286
GO_process	GO:0015986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015986
GO_process	GO:0015991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015991
GO_process	GO:0016241	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016241
GO_process	GO:0033572	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033572
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0070072	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070072
GO_process	GO:0090383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090383
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ATP6V0A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP6V0A2
GeneID	23545	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23545
GeneTree	ENSGT00390000004941	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000004941
H-InvDB	HIX0011113	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0011113
HGNC	HGNC:18481	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18481
HOGENOM	HOG000037059	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000037059&db=HOGENOM6
HOVERGEN	HBG014606	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG014606&db=HOVERGEN
HPA	HPA044279	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA044279
InParanoid	Q9Y487	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y487
IntAct	Q9Y487	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9Y487*
InterPro	IPR002490	http://www.ebi.ac.uk/interpro/entry/IPR002490
InterPro	IPR026028	http://www.ebi.ac.uk/interpro/entry/IPR026028
Jabion	23545	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=23545
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Disease	H00557	http://www.genome.jp/dbget-bin/www_bget?H00557
KEGG_Gene	hsa:23545	http://www.genome.jp/dbget-bin/www_bget?hsa:23545
KEGG_Orthology	KO:K02154	http://www.genome.jp/dbget-bin/www_bget?KO:K02154
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04142	http://www.genome.jp/kegg-bin/show_pathway?ko04142
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04966	http://www.genome.jp/kegg-bin/show_pathway?ko04966
KEGG_Pathway	ko05110	http://www.genome.jp/kegg-bin/show_pathway?ko05110
KEGG_Pathway	ko05120	http://www.genome.jp/kegg-bin/show_pathway?ko05120
KEGG_Pathway	ko05152	http://www.genome.jp/kegg-bin/show_pathway?ko05152
KEGG_Pathway	ko05323	http://www.genome.jp/kegg-bin/show_pathway?ko05323
MIM	219200	http://www.ncbi.nlm.nih.gov/omim/219200
MIM	278250	http://www.ncbi.nlm.nih.gov/omim/278250
MIM	611716	http://www.ncbi.nlm.nih.gov/omim/611716
OMA	HPPAEHK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HPPAEHK
Orphanet	2834	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=2834
Orphanet	357074	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=357074
OrthoDB	EOG091G01BI	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01BI
PANTHER	PTHR11629	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11629
PSORT	swissprot:VPP2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VPP2_HUMAN
PSORT-B	swissprot:VPP2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VPP2_HUMAN
PSORT2	swissprot:VPP2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VPP2_HUMAN
Pfam	PF01496	http://pfam.xfam.org/family/PF01496
PharmGKB	PA38549	http://www.pharmgkb.org/do/serve?objId=PA38549&objCls=Gene
Phobius	swissprot:VPP2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VPP2_HUMAN
PhylomeDB	Q9Y487	http://phylomedb.org/?seqid=Q9Y487
ProteinModelPortal	Q9Y487	http://www.proteinmodelportal.org/query/uniprot/Q9Y487
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16415858	http://www.ncbi.nlm.nih.gov/pubmed/16415858
PubMed	17295899	http://www.ncbi.nlm.nih.gov/pubmed/17295899
PubMed	17525332	http://www.ncbi.nlm.nih.gov/pubmed/17525332
PubMed	18157129	http://www.ncbi.nlm.nih.gov/pubmed/18157129
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
Reactome	R-HSA-1222556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1222556
Reactome	R-HSA-77387	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-77387
Reactome	R-HSA-917977	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917977
Reactome	R-HSA-983712	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983712
RefSeq	NP_036595	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_036595
STRING	9606.ENSP00000332247	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000332247&targetmode=cogs
STRING	COG1269	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1269&targetmode=cogs
UCSC	uc001ufr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001ufr&org=rat
UniGene	Hs.25786	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.25786
UniProtKB	VPP2_HUMAN	http://www.uniprot.org/uniprot/VPP2_HUMAN
UniProtKB-AC	Q9Y487	http://www.uniprot.org/uniprot/Q9Y487
charge	swissprot:VPP2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VPP2_HUMAN
eggNOG	COG1269	http://eggnogapi.embl.de/nog_data/html/tree/COG1269
eggNOG	KOG2189	http://eggnogapi.embl.de/nog_data/html/tree/KOG2189
epestfind	swissprot:VPP2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VPP2_HUMAN
garnier	swissprot:VPP2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VPP2_HUMAN
helixturnhelix	swissprot:VPP2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VPP2_HUMAN
hmoment	swissprot:VPP2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VPP2_HUMAN
iep	swissprot:VPP2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VPP2_HUMAN
inforesidue	swissprot:VPP2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VPP2_HUMAN
neXtProt	NX_Q9Y487	http://www.nextprot.org/db/entry/NX_Q9Y487
octanol	swissprot:VPP2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VPP2_HUMAN
pepcoil	swissprot:VPP2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VPP2_HUMAN
pepdigest	swissprot:VPP2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VPP2_HUMAN
pepinfo	swissprot:VPP2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VPP2_HUMAN
pepnet	swissprot:VPP2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VPP2_HUMAN
pepstats	swissprot:VPP2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VPP2_HUMAN
pepwheel	swissprot:VPP2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VPP2_HUMAN
pepwindow	swissprot:VPP2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VPP2_HUMAN
sigcleave	swissprot:VPP2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VPP2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	RHD_HUMAN	Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=Long; IsoId=Q02161-1; Sequence=Displayed; Name=2; Synonyms=Short 1; IsoId=Q02161-2; Sequence=VSP_005706; Name=3; Synonyms=Short 2; IsoId=Q02161-3; Sequence=VSP_005707, VSP_005708; Name=4; IsoId=Q02161-4; Sequence=VSP_047797; Name=5; IsoId=Q02161-5; Sequence=VSP_047796; Name=6; IsoId=Q02161-6; Sequence=VSP_047795, VSP_047798; 
# AltName	RHD_HUMAN	CD240D
# AltName	RHD_HUMAN	RHXIII
# AltName	RHD_HUMAN	Rh polypeptide 2
# AltName	RHD_HUMAN	Rhesus D antigen
# CCDS	CCDS262	-. [Q02161-1]
# CCDS	CCDS53285	-. [Q02161-2]
# CCDS	CCDS60028	-. [Q02161-4]
# CCDS	CCDS60030	-. [Q02161-5]
# CCDS	CCDS60031	-. [Q02161-6]
# Ensembl	ENST00000328664	ENSP00000331871; ENSG00000187010. [Q02161-1]
# Ensembl	ENST00000342055	ENSP00000339577; ENSG00000187010. [Q02161-4]
# Ensembl	ENST00000357542	ENSP00000350150; ENSG00000187010. [Q02161-5]
# Ensembl	ENST00000417538	ENSP00000396420; ENSG00000187010. [Q02161-6]
# Ensembl	ENST00000454452	ENSP00000413849; ENSG00000187010. [Q02161-2]
# ExpressionAtlas	Q02161	baseline and differential
# FUNCTION	RHD_HUMAN	May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane. 
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_function	GO:0008519	ammonium transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0015695	organic cation transport; IBA:GO_Central.
# GO_process	GO:0019740	nitrogen utilization; IBA:GO_Central.
# GO_process	GO:0072488	ammonium transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.10.3430.10	-; 1.
# Genevisible	Q02161	HS
# HGNC	HGNC:10009	RHD
# InterPro	IPR001905	Ammonium_transpt
# InterPro	IPR002229	RhesusRHD
# InterPro	IPR024041	NH4_transpt_AmtB-like_dom
# InterPro	IPR029020	Ammonium/urea_transptr
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko04090	 Cellular antigens
# MIM	111680	gene
# Organism	RHD_HUMAN	Homo sapiens (Human)
# Orphanet	71275	Rh deficiency syndrome
# PANTHER	PTHR11730	PTHR11730
# PIR	A46368	A46368
# PIR	I52615	I52615
# POLYMORPHISM	RHD_HUMAN	RHD and RHCE are responsible for the Rh blood group system. The molecular basis of the Tar=Rh40 blood group antigen is a polymorphism in position 110. 
# PRINTS	PR00342	RHESUSRHD
# Pfam	PF00909	Ammonium_transp
# Proteomes	UP000005640	Chromosome 1
# RecName	RHD_HUMAN	Blood group Rh(D) polypeptide
# RefSeq	NP_001121163	NM_001127691.2. [Q02161-2]
# RefSeq	NP_001269797	NM_001282868.1. [Q02161-6]
# RefSeq	NP_001269798	NM_001282869.1. [Q02161-5]
# RefSeq	NP_001269800	NM_001282871.1. [Q02161-4]
# RefSeq	NP_057208	NM_016124.4
# SIMILARITY	Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	RHD_HUMAN	Membrane; Multi-pass membrane protein. 
# SUPFAM	SSF111352	SSF111352
# TCDB	1.A.11.4	the ammonium transporter channel (amt) family
# TISSUE SPECIFICITY	RHD_HUMAN	Restricted to tissues or cell lines expressing erythroid characters. 
# UCSC	uc001bjz	human. [Q02161-1]
# WEB RESOURCE	RHD_HUMAN	Name=dbRBC/BGMUT; Note=Blood group antigen gene mutation database; URL="https //www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=rh";
# eggNOG	ENOG410XTF8	LUCA
# eggNOG	KOG3796	Eukaryota
BLAST	swissprot:RHD_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:RHD_HUMAN
BioCyc	ZFISH:ENSG00000178847-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000178847-MONOMER
COXPRESdb	6007	http://coxpresdb.jp/data/gene/6007.shtml
DOI	10.1002/ajh.2830490115	http://dx.doi.org/10.1002/ajh.2830490115
DOI	10.1007/BF00222717	http://dx.doi.org/10.1007/BF00222717
DOI	10.1016/j.transci.2005.10.001	http://dx.doi.org/10.1016/j.transci.2005.10.001
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1042/bj2561043	http://dx.doi.org/10.1042/bj2561043
DOI	10.1073/pnas.85.11.4042	http://dx.doi.org/10.1073/pnas.85.11.4042
DOI	10.1073/pnas.89.22.10925	http://dx.doi.org/10.1073/pnas.89.22.10925
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
EMBL	AB018966	http://www.ebi.ac.uk/ena/data/view/AB018966
EMBL	AB018967	http://www.ebi.ac.uk/ena/data/view/AB018967
EMBL	AB018968	http://www.ebi.ac.uk/ena/data/view/AB018968
EMBL	AB018969	http://www.ebi.ac.uk/ena/data/view/AB018969
EMBL	AL928711	http://www.ebi.ac.uk/ena/data/view/AL928711
EMBL	AY751492	http://www.ebi.ac.uk/ena/data/view/AY751492
EMBL	AY751493	http://www.ebi.ac.uk/ena/data/view/AY751493
EMBL	AY751495	http://www.ebi.ac.uk/ena/data/view/AY751495
EMBL	L08429	http://www.ebi.ac.uk/ena/data/view/L08429
EMBL	S57971	http://www.ebi.ac.uk/ena/data/view/S57971
EMBL	S70174	http://www.ebi.ac.uk/ena/data/view/S70174
EMBL	S73913	http://www.ebi.ac.uk/ena/data/view/S73913
EMBL	S78509	http://www.ebi.ac.uk/ena/data/view/S78509
EMBL	X63094	http://www.ebi.ac.uk/ena/data/view/X63094
EMBL	X63097	http://www.ebi.ac.uk/ena/data/view/X63097
Ensembl	ENST00000328664	http://www.ensembl.org/id/ENST00000328664
Ensembl	ENST00000342055	http://www.ensembl.org/id/ENST00000342055
Ensembl	ENST00000357542	http://www.ensembl.org/id/ENST00000357542
Ensembl	ENST00000417538	http://www.ensembl.org/id/ENST00000417538
Ensembl	ENST00000454452	http://www.ensembl.org/id/ENST00000454452
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0008519	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008519
GO_process	GO:0015695	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015695
GO_process	GO:0019740	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019740
GO_process	GO:0072488	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072488
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.10.3430.10	http://www.cathdb.info/version/latest/superfamily/1.10.3430.10
GeneCards	RHD	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=RHD
GeneID	6007	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6007
GeneTree	ENSGT00390000005787	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000005787
HGNC	HGNC:10009	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10009
HOVERGEN	HBG004374	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004374&db=HOVERGEN
InParanoid	Q02161	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q02161
InterPro	IPR001905	http://www.ebi.ac.uk/interpro/entry/IPR001905
InterPro	IPR002229	http://www.ebi.ac.uk/interpro/entry/IPR002229
InterPro	IPR024041	http://www.ebi.ac.uk/interpro/entry/IPR024041
InterPro	IPR029020	http://www.ebi.ac.uk/interpro/entry/IPR029020
Jabion	6007	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6007
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko04090	http://www.genome.jp/dbget-bin/www_bget?ko04090
KEGG_Gene	hsa:6007	http://www.genome.jp/dbget-bin/www_bget?hsa:6007
KEGG_Orthology	KO:K06579	http://www.genome.jp/dbget-bin/www_bget?KO:K06579
MIM	111680	http://www.ncbi.nlm.nih.gov/omim/111680
OMA	XFPHLAV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=XFPHLAV
Orphanet	71275	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=71275
OrthoDB	EOG091G06KX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G06KX
PANTHER	PTHR11730	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11730
PRINTS	PR00342	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00342
PSORT	swissprot:RHD_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:RHD_HUMAN
PSORT-B	swissprot:RHD_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:RHD_HUMAN
PSORT2	swissprot:RHD_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:RHD_HUMAN
Pfam	PF00909	http://pfam.xfam.org/family/PF00909
PharmGKB	PA34387	http://www.pharmgkb.org/do/serve?objId=PA34387&objCls=Gene
Phobius	swissprot:RHD_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:RHD_HUMAN
PhylomeDB	Q02161	http://phylomedb.org/?seqid=Q02161
ProteinModelPortal	Q02161	http://www.proteinmodelportal.org/query/uniprot/Q02161
PubMed	1379850	http://www.ncbi.nlm.nih.gov/pubmed/1379850
PubMed	1438298	http://www.ncbi.nlm.nih.gov/pubmed/1438298
PubMed	16510313	http://www.ncbi.nlm.nih.gov/pubmed/16510313
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	1898705	http://www.ncbi.nlm.nih.gov/pubmed/1898705
PubMed	3131772	http://www.ncbi.nlm.nih.gov/pubmed/3131772
PubMed	3135863	http://www.ncbi.nlm.nih.gov/pubmed/3135863
PubMed	3146980	http://www.ncbi.nlm.nih.gov/pubmed/3146980
PubMed	7606008	http://www.ncbi.nlm.nih.gov/pubmed/7606008
PubMed	7741145	http://www.ncbi.nlm.nih.gov/pubmed/7741145
PubMed	7916743	http://www.ncbi.nlm.nih.gov/pubmed/7916743
PubMed	8080999	http://www.ncbi.nlm.nih.gov/pubmed/8080999
PubMed	8180407	http://www.ncbi.nlm.nih.gov/pubmed/8180407
PubMed	8329718	http://www.ncbi.nlm.nih.gov/pubmed/8329718
RefSeq	NP_001121163	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001121163
RefSeq	NP_001269797	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269797
RefSeq	NP_001269798	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269798
RefSeq	NP_001269800	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269800
RefSeq	NP_057208	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_057208
STRING	9606.ENSP00000331871	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000331871&targetmode=cogs
SUPFAM	SSF111352	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF111352
TCDB	1.A.11.4	http://www.tcdb.org/search/result.php?tc=1.A.11.4
UCSC	uc001bjz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001bjz&org=rat
UniGene	Hs.449968	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.449968
UniProtKB	RHD_HUMAN	http://www.uniprot.org/uniprot/RHD_HUMAN
UniProtKB-AC	Q02161	http://www.uniprot.org/uniprot/Q02161
charge	swissprot:RHD_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:RHD_HUMAN
eggNOG	ENOG410XTF8	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XTF8
eggNOG	KOG3796	http://eggnogapi.embl.de/nog_data/html/tree/KOG3796
epestfind	swissprot:RHD_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:RHD_HUMAN
garnier	swissprot:RHD_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:RHD_HUMAN
helixturnhelix	swissprot:RHD_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:RHD_HUMAN
hmoment	swissprot:RHD_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:RHD_HUMAN
iep	swissprot:RHD_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:RHD_HUMAN
inforesidue	swissprot:RHD_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:RHD_HUMAN
neXtProt	NX_Q02161	http://www.nextprot.org/db/entry/NX_Q02161
octanol	swissprot:RHD_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:RHD_HUMAN
pepcoil	swissprot:RHD_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:RHD_HUMAN
pepdigest	swissprot:RHD_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:RHD_HUMAN
pepinfo	swissprot:RHD_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:RHD_HUMAN
pepnet	swissprot:RHD_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:RHD_HUMAN
pepstats	swissprot:RHD_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:RHD_HUMAN
pepwheel	swissprot:RHD_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:RHD_HUMAN
pepwindow	swissprot:RHD_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:RHD_HUMAN
sigcleave	swissprot:RHD_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:RHD_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	MAGT1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H0U3-1; Sequence=Displayed; Name=2; IsoId=Q9H0U3-2; Sequence=VSP_056556, VSP_056557; Note=No experimental confirmation available.; 
# AltName	MAGT1_HUMAN	Implantation-associated protein
# BioGrid	123856	34
# CAUTION	MAGT1_HUMAN	Although MAGT1 has been reported to be involved in mental retardation (PubMed 18455129), its pathological role is questionable (PubMed 23871722). {ECO 0000305|PubMed 18455129, ECO 0000305|PubMed 23871722}.
# ChiTaRS	MAGT1	human
# DISEASE	MAGT1_HUMAN	Immunodeficiency, X-linked, with magnesium defect, Epstein-Barr virus infection and neoplasia (XMEN) [MIM 300853]  A disease characterized by CD4 lymphopenia, severe chronic viral infections, and defective T-lymphocyte activation. {ECO 0000269|PubMed 21796205}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000373336	ENSP00000362433; ENSG00000102158. [Q9H0U3-2]
# Ensembl	ENST00000618282	ENSP00000480732; ENSG00000102158. [Q9H0U3-1]
# ExpressionAtlas	Q9H0U3	baseline and differential
# FUNCTION	MAGT1_HUMAN	May be involved in N-glycosylation through its association with N-oligosaccharyl transferase. May be involved in Mg(2+) transport in epithelial cells. {ECO 0000269|PubMed 15804357, ECO 0000269|PubMed 19717468}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; NAS:UniProtKB.
# GO_component	GO:0008250	oligosaccharyltransferase complex; IDA:HGNC.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_function	GO:0015095	magnesium ion transmembrane transporter activity; IMP:UniProtKB.
# GO_process	GO:0006487	protein N-linked glycosylation; NAS:UniProtKB.
# GO_process	GO:0015693	magnesium ion transport; IMP:UniProtKB.
# GO_process	GO:0018279	protein N-linked glycosylation via asparagine; IBA:GO_Central.
# GO_process	GO:0050890	cognition; IMP:UniProtKB.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.30.10	-; 1.
# Genevisible	Q9H0U3	HS
# HGNC	HGNC:28880	MAGT1
# INDUCTION	Up-regulated by low extracellular Mg(2+). {ECO:0000269|PubMed	19717468}. 
# IntAct	Q9H0U3	15
# InterPro	IPR006844	Mg_transporter-1
# InterPro	IPR012336	Thioredoxin-like_fold
# InterPro	IPR021149	OligosaccharylTrfase_OST3/OST6
# KEGG_Disease	H00480	[Congenital disorder; Mental retardation] Non-syndromic X-linked mental retardation
# MIM	300715	gene
# MIM	300853	phenotype
# Organism	MAGT1_HUMAN	Homo sapiens (Human)
# Orphanet	317476	X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
# Orphanet	777	X-linked non-syndromic intellectual disability
# PANTHER	PTHR12692:SF2	PTHR12692:SF2
# Pfam	PF04756	OST3_OST6
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-446203	Asparagine N-linked glycosylation
# Reactome	R-HSA-5223345	Miscellaneous transport and binding events
# Reactome	R-HSA-6798695	Neutrophil degranulation
# RecName	MAGT1_HUMAN	Magnesium transporter protein 1
# RefSeq	NP_115497	NM_032121.5
# SIMILARITY	Belongs to the OST3/OST6 family. {ECO	0000305}. 
# SIMILARITY	Contains 1 thioredoxin domain. {ECO	0000305}. 
# SUBCELLULAR LOCATION	MAGT1_HUMAN	Cell membrane {ECO 0000269|PubMed 19717468}; Multi-pass membrane protein {ECO 0000269|PubMed 19717468}. Endoplasmic reticulum membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUBUNIT	Weakly associates with the oligosaccharyl transferase (OST) complex which contains at least RPN1/ribophorin I, RPN2/ribophorin II, OST48, DAD1, and either STT3A or STT3B. {ECO	0000250}. 
# SUPFAM	SSF52833	SSF52833
# TCDB	1.A.76.1	the magnesium transporter1 (magt1) family
# TISSUE SPECIFICITY	MAGT1_HUMAN	Ubiquitous. Expressed at very low levels in brain, lung and kidney. {ECO 0000269|PubMed 12887896, ECO 0000269|PubMed 15804357, ECO 0000269|PubMed 19717468}. 
# UCSC	uc065abq	human. [Q9H0U3-1]
# eggNOG	ENOG410XR1F	LUCA
# eggNOG	KOG2603	Eukaryota
BLAST	swissprot:MAGT1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MAGT1_HUMAN
BioCyc	ZFISH:ENSG00000102158-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000102158-MONOMER
COXPRESdb	84061	http://coxpresdb.jp/data/gene/84061.shtml
CleanEx	HS_MAGT1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_MAGT1
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/S1097-2765(03)00243-0	http://dx.doi.org/10.1016/S1097-2765(03)00243-0
DOI	10.1016/j.ajhg.2008.03.021	http://dx.doi.org/10.1016/j.ajhg.2008.03.021
DOI	10.1016/j.ajhg.2013.06.013	http://dx.doi.org/10.1016/j.ajhg.2013.06.013
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1038/nature10246	http://dx.doi.org/10.1038/nature10246
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0908332106	http://dx.doi.org/10.1073/pnas.0908332106
DOI	10.1093/dnares/12.2.117	http://dx.doi.org/10.1093/dnares/12.2.117
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1101/gr.GR1547R	http://dx.doi.org/10.1101/gr.GR1547R
DOI	10.1186/1471-2164-6-48	http://dx.doi.org/10.1186/1471-2164-6-48
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AK075394	http://www.ebi.ac.uk/ena/data/view/AK075394
EMBL	AK223131	http://www.ebi.ac.uk/ena/data/view/AK223131
EMBL	AK314309	http://www.ebi.ac.uk/ena/data/view/AK314309
EMBL	AL136636	http://www.ebi.ac.uk/ena/data/view/AL136636
EMBL	AL138743	http://www.ebi.ac.uk/ena/data/view/AL138743
EMBL	AL138743	http://www.ebi.ac.uk/ena/data/view/AL138743
EMBL	AL356235	http://www.ebi.ac.uk/ena/data/view/AL356235
EMBL	AL356235	http://www.ebi.ac.uk/ena/data/view/AL356235
EMBL	AY358691	http://www.ebi.ac.uk/ena/data/view/AY358691
EMBL	BC041014	http://www.ebi.ac.uk/ena/data/view/BC041014
EMBL	BC060842	http://www.ebi.ac.uk/ena/data/view/BC060842
EMBL	BC063037	http://www.ebi.ac.uk/ena/data/view/BC063037
EMBL	CH471104	http://www.ebi.ac.uk/ena/data/view/CH471104
EMBL	CH471104	http://www.ebi.ac.uk/ena/data/view/CH471104
EMBL	CH471104	http://www.ebi.ac.uk/ena/data/view/CH471104
EMBL	DQ000004	http://www.ebi.ac.uk/ena/data/view/DQ000004
Ensembl	ENST00000373336	http://www.ensembl.org/id/ENST00000373336
Ensembl	ENST00000618282	http://www.ensembl.org/id/ENST00000618282
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0008250	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008250
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0015095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015095
GO_process	GO:0006487	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006487
GO_process	GO:0015693	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015693
GO_process	GO:0018279	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018279
GO_process	GO:0050890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050890
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.30.10	http://www.cathdb.info/version/latest/superfamily/3.40.30.10
GeneCards	MAGT1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=MAGT1
GeneID	84061	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84061
GeneTree	ENSGT00390000012030	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000012030
H-InvDB	HIX0016886	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0016886
HGNC	HGNC:28880	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:28880
HOGENOM	HOG000143405	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000143405&db=HOGENOM6
HOVERGEN	HBG002493	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG002493&db=HOVERGEN
HPA	HPA049851	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA049851
InParanoid	Q9H0U3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9H0U3
IntAct	Q9H0U3	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9H0U3*
InterPro	IPR006844	http://www.ebi.ac.uk/interpro/entry/IPR006844
InterPro	IPR012336	http://www.ebi.ac.uk/interpro/entry/IPR012336
InterPro	IPR021149	http://www.ebi.ac.uk/interpro/entry/IPR021149
Jabion	84061	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=84061
KEGG_Disease	H00480	http://www.genome.jp/dbget-bin/www_bget?H00480
KEGG_Gene	hsa:84061	http://www.genome.jp/dbget-bin/www_bget?hsa:84061
MIM	300715	http://www.ncbi.nlm.nih.gov/omim/300715
MIM	300853	http://www.ncbi.nlm.nih.gov/omim/300853
MINT	MINT-3972987	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3972987
Orphanet	317476	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=317476
Orphanet	777	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=777
PANTHER	PTHR12692:SF2	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12692:SF2
PSORT	swissprot:MAGT1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MAGT1_HUMAN
PSORT-B	swissprot:MAGT1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MAGT1_HUMAN
PSORT2	swissprot:MAGT1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MAGT1_HUMAN
Pfam	PF04756	http://pfam.xfam.org/family/PF04756
PharmGKB	PA162394900	http://www.pharmgkb.org/do/serve?objId=PA162394900&objCls=Gene
Phobius	swissprot:MAGT1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MAGT1_HUMAN
PhylomeDB	Q9H0U3	http://phylomedb.org/?seqid=Q9H0U3
ProteinModelPortal	Q9H0U3	http://www.proteinmodelportal.org/query/uniprot/Q9H0U3
PubMed	11230166	http://www.ncbi.nlm.nih.gov/pubmed/11230166
PubMed	12887896	http://www.ncbi.nlm.nih.gov/pubmed/12887896
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	15804357	http://www.ncbi.nlm.nih.gov/pubmed/15804357
PubMed	16303743	http://www.ncbi.nlm.nih.gov/pubmed/16303743
PubMed	18455129	http://www.ncbi.nlm.nih.gov/pubmed/18455129
PubMed	19717468	http://www.ncbi.nlm.nih.gov/pubmed/19717468
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21796205	http://www.ncbi.nlm.nih.gov/pubmed/21796205
PubMed	23871722	http://www.ncbi.nlm.nih.gov/pubmed/23871722
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-446203	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-446203
Reactome	R-HSA-5223345	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5223345
Reactome	R-HSA-6798695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6798695
RefSeq	NP_115497	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_115497
SMR	Q9H0U3	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9H0U3
STRING	9606.ENSP00000354649	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000354649&targetmode=cogs
SUPFAM	SSF52833	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833
TCDB	1.A.76.1	http://www.tcdb.org/search/result.php?tc=1.A.76.1
UCSC	uc065abq	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc065abq&org=rat
UniGene	Hs.323562	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.323562
UniProtKB	MAGT1_HUMAN	http://www.uniprot.org/uniprot/MAGT1_HUMAN
UniProtKB-AC	Q9H0U3	http://www.uniprot.org/uniprot/Q9H0U3
charge	swissprot:MAGT1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MAGT1_HUMAN
eggNOG	ENOG410XR1F	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XR1F
eggNOG	KOG2603	http://eggnogapi.embl.de/nog_data/html/tree/KOG2603
epestfind	swissprot:MAGT1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MAGT1_HUMAN
garnier	swissprot:MAGT1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MAGT1_HUMAN
helixturnhelix	swissprot:MAGT1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MAGT1_HUMAN
hmoment	swissprot:MAGT1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MAGT1_HUMAN
iep	swissprot:MAGT1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MAGT1_HUMAN
inforesidue	swissprot:MAGT1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MAGT1_HUMAN
neXtProt	NX_Q9H0U3	http://www.nextprot.org/db/entry/NX_Q9H0U3
octanol	swissprot:MAGT1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MAGT1_HUMAN
pepcoil	swissprot:MAGT1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MAGT1_HUMAN
pepdigest	swissprot:MAGT1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MAGT1_HUMAN
pepinfo	swissprot:MAGT1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MAGT1_HUMAN
pepnet	swissprot:MAGT1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MAGT1_HUMAN
pepstats	swissprot:MAGT1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MAGT1_HUMAN
pepwheel	swissprot:MAGT1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MAGT1_HUMAN
pepwindow	swissprot:MAGT1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MAGT1_HUMAN
sigcleave	swissprot:MAGT1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MAGT1_HUMAN
## Database	ID	URL or Descriptions
# AltName	CCG1_HUMAN	Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma
# DrugBank	DB00308	Ibutilide
# DrugBank	DB00343	Diltiazem
# DrugBank	DB00421	Spironolactone
# DrugBank	DB00528	Lercanidipine
# DrugBank	DB00653	Magnesium Sulfate
# DrugBank	DB00898	Ethanol
# DrugBank	DB01054	Nitrendipine
# DrugBank	DB04842	Fluspirilene
# Ensembl	ENST00000226021	ENSP00000226021; ENSG00000108878
# FUNCTION	CCG1_HUMAN	This protein is a subunit of the dihydropyridine (DHP) sensitive calcium channel. Plays a role in excitation-contraction coupling. The skeletal muscle DHP-sensitive Ca(2+) channel may function only as a multiple subunit complex. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005891	voltage-gated calcium channel complex; TAS:ProtInc.
# GO_function	GO:0005245	voltage-gated calcium channel activity; TAS:ProtInc.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006936	muscle contraction; TAS:ProtInc.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:0070296	sarcoplasmic reticulum calcium ion transport; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q06432	HS
# HGNC	HGNC:1405	CACNG1
# INTERACTION	CCG1_HUMAN	A8KA83 -; NbExp=3; IntAct=EBI-9686780, EBI-10174961; 
# IntAct	Q06432	2
# InterPro	IPR004031	PMP22/EMP/MP20/Claudin
# InterPro	IPR005421	VDCC_g1su
# InterPro	IPR008368	VDCC_gsu
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04010	MAPK signaling pathway
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05410	Hypertrophic cardiomyopathy (HCM)
# KEGG_Pathway	ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
# KEGG_Pathway	ko05414	Dilated cardiomyopathy
# MIM	114209	gene
# Organism	CCG1_HUMAN	Homo sapiens (Human)
# PIR	A46658	A46658
# PRINTS	PR01601	VDCCGAMMA1
# PRINTS	PR01792	VDCCGAMMA
# Pfam	PF13903	Claudin_2
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# Reactome	R-HSA-5576893	Phase 2 - plateau phase
# Reactome	R-HSA-5576894	Phase 1 - inactivation of fast Na+ channels
# RecName	CCG1_HUMAN	Voltage-dependent calcium channel gamma-1 subunit
# RefSeq	NP_000718	NM_000727.3
# SIMILARITY	Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	CCG1_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	The L-type calcium channel is composed of five subunits	 alpha-1, alpha-2/delta, beta and gamma. 
# TCDB	8.A.16.1	the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family
# TISSUE SPECIFICITY	CCG1_HUMAN	Skeletal muscle. 
# UCSC	uc002jfu	human
# eggNOG	ENOG410IH0I	Eukaryota
# eggNOG	ENOG4111J5G	LUCA
BLAST	swissprot:CCG1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CCG1_HUMAN
BioCyc	ZFISH:ENSG00000108878-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000108878-MONOMER
COXPRESdb	786	http://coxpresdb.jp/data/gene/786.shtml
CleanEx	HS_CACNG1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CACNG1
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00308	http://www.drugbank.ca/drugs/DB00308
DrugBank	DB00343	http://www.drugbank.ca/drugs/DB00343
DrugBank	DB00421	http://www.drugbank.ca/drugs/DB00421
DrugBank	DB00528	http://www.drugbank.ca/drugs/DB00528
DrugBank	DB00653	http://www.drugbank.ca/drugs/DB00653
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01054	http://www.drugbank.ca/drugs/DB01054
DrugBank	DB04842	http://www.drugbank.ca/drugs/DB04842
EMBL	AK313852	http://www.ebi.ac.uk/ena/data/view/AK313852
EMBL	BC069493	http://www.ebi.ac.uk/ena/data/view/BC069493
EMBL	BC113486	http://www.ebi.ac.uk/ena/data/view/BC113486
EMBL	BC113492	http://www.ebi.ac.uk/ena/data/view/BC113492
EMBL	CH471099	http://www.ebi.ac.uk/ena/data/view/CH471099
EMBL	L07738	http://www.ebi.ac.uk/ena/data/view/L07738
EMBL	Z19587	http://www.ebi.ac.uk/ena/data/view/Z19587
EMBL	Z19603	http://www.ebi.ac.uk/ena/data/view/Z19603
Ensembl	ENST00000226021	http://www.ensembl.org/id/ENST00000226021
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005891
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006936	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006936
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:0070296	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070296
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	CACNG1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CACNG1
GeneID	786	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=786
GeneTree	ENSGT00390000007786	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000007786
HGNC	HGNC:1405	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1405
HOGENOM	HOG000293219	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000293219&db=HOGENOM6
HOVERGEN	HBG003868	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003868&db=HOVERGEN
HPA	CAB016200	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB016200
HPA	CAB021109	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB021109
HPA	CAB047350	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB047350
InParanoid	Q06432	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q06432
IntAct	Q06432	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q06432*
InterPro	IPR004031	http://www.ebi.ac.uk/interpro/entry/IPR004031
InterPro	IPR005421	http://www.ebi.ac.uk/interpro/entry/IPR005421
InterPro	IPR008368	http://www.ebi.ac.uk/interpro/entry/IPR008368
Jabion	786	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=786
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:786	http://www.genome.jp/dbget-bin/www_bget?hsa:786
KEGG_Orthology	KO:K04866	http://www.genome.jp/dbget-bin/www_bget?KO:K04866
KEGG_Pathway	ko04010	http://www.genome.jp/kegg-bin/show_pathway?ko04010
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05410	http://www.genome.jp/kegg-bin/show_pathway?ko05410
KEGG_Pathway	ko05412	http://www.genome.jp/kegg-bin/show_pathway?ko05412
KEGG_Pathway	ko05414	http://www.genome.jp/kegg-bin/show_pathway?ko05414
MIM	114209	http://www.ncbi.nlm.nih.gov/omim/114209
OMA	LKPASMF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LKPASMF
OrthoDB	EOG091G0IU0	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0IU0
PRINTS	PR01601	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01601
PRINTS	PR01792	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01792
PSORT	swissprot:CCG1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CCG1_HUMAN
PSORT-B	swissprot:CCG1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CCG1_HUMAN
PSORT2	swissprot:CCG1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CCG1_HUMAN
Pfam	PF13903	http://pfam.xfam.org/family/PF13903
PharmGKB	PA26015	http://www.pharmgkb.org/do/serve?objId=PA26015&objCls=Gene
Phobius	swissprot:CCG1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CCG1_HUMAN
PhylomeDB	Q06432	http://phylomedb.org/?seqid=Q06432
ProteinModelPortal	Q06432	http://www.proteinmodelportal.org/query/uniprot/Q06432
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	8387489	http://www.ncbi.nlm.nih.gov/pubmed/8387489
PubMed	8404045	http://www.ncbi.nlm.nih.gov/pubmed/8404045
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
Reactome	R-HSA-5576893	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576893
Reactome	R-HSA-5576894	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576894
RefSeq	NP_000718	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000718
STRING	9606.ENSP00000226021	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000226021&targetmode=cogs
TCDB	8.A.16.1	http://www.tcdb.org/search/result.php?tc=8.A.16.1
UCSC	uc002jfu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002jfu&org=rat
UniGene	Hs.147989	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.147989
UniProtKB	CCG1_HUMAN	http://www.uniprot.org/uniprot/CCG1_HUMAN
UniProtKB-AC	Q06432	http://www.uniprot.org/uniprot/Q06432
charge	swissprot:CCG1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CCG1_HUMAN
eggNOG	ENOG410IH0I	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IH0I
eggNOG	ENOG4111J5G	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111J5G
epestfind	swissprot:CCG1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CCG1_HUMAN
garnier	swissprot:CCG1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CCG1_HUMAN
helixturnhelix	swissprot:CCG1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CCG1_HUMAN
hmoment	swissprot:CCG1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CCG1_HUMAN
iep	swissprot:CCG1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CCG1_HUMAN
inforesidue	swissprot:CCG1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CCG1_HUMAN
neXtProt	NX_Q06432	http://www.nextprot.org/db/entry/NX_Q06432
octanol	swissprot:CCG1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CCG1_HUMAN
pepcoil	swissprot:CCG1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CCG1_HUMAN
pepdigest	swissprot:CCG1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CCG1_HUMAN
pepinfo	swissprot:CCG1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CCG1_HUMAN
pepnet	swissprot:CCG1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CCG1_HUMAN
pepstats	swissprot:CCG1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CCG1_HUMAN
pepwheel	swissprot:CCG1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CCG1_HUMAN
pepwindow	swissprot:CCG1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CCG1_HUMAN
sigcleave	swissprot:CCG1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CCG1_HUMAN
## Database	ID	URL or Descriptions
# AltName	MPC2_HUMAN	Brain protein 44
# BioGrid	117389	12
# Ensembl	ENST00000271373	ENSP00000271373; ENSG00000143158
# Ensembl	ENST00000367846	ENSP00000356820; ENSG00000143158
# ExpressionAtlas	O95563	baseline and differential
# FUNCTION	MPC2_HUMAN	Mediates the uptake of pyruvate into mitochondria. {ECO 0000269|PubMed 22628558}. 
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005739	mitochondrion; IDA:LIFEdb.
# GO_component	GO:0005743	mitochondrial inner membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0050833	pyruvate transmembrane transporter activity; IEA:Ensembl.
# GO_process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
# GO_process	GO:0061732	mitochondrial acetyl-CoA biosynthetic process from pyruvate; IEA:Ensembl.
# GO_process	GO:1902361	mitochondrial pyruvate transmembrane transport; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005739	mitochondrion
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006790	sulfur compound metabolic process
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0051186	cofactor metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	O95563	HS
# HGNC	HGNC:24515	MPC2
# IntAct	O95563	2
# InterPro	IPR005336	MPC
# MIM	614737	gene
# Organism	MPC2_HUMAN	Homo sapiens (Human)
# PIR	T14797	T14797
# Pfam	PF03650	MPC
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-70268	Pyruvate metabolism
# RecName	MPC2_HUMAN	Mitochondrial pyruvate carrier 2
# RefSeq	NP_001137146	NM_001143674.3
# RefSeq	NP_056230	NM_015415.3
# RefSeq	XP_006711329	XM_006711266.3
# SIMILARITY	Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	MPC2_HUMAN	Mitochondrion inner membrane {ECO 0000269|PubMed 22628558}; Multi-pass membrane protein {ECO 0000269|PubMed 22628558}. 
# SUBUNIT	The functional 150 kDa pyruvate import complex is a heteromer of MPC1 and MPC2. {ECO:0000250|UniProtKB	Q9D023}. 
# TCDB	2.A.105.1	the mitochondrial pyruvate carrier (mpc) family
# UCSC	uc001ges	human
# eggNOG	ENOG4111UER	LUCA
# eggNOG	KOG1589	Eukaryota
BLAST	swissprot:MPC2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MPC2_HUMAN
BioCyc	ZFISH:ENSG00000143158-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000143158-MONOMER
COXPRESdb	25874	http://coxpresdb.jp/data/gene/25874.shtml
CleanEx	HS_BRP44	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_BRP44
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1101/gr.GR1547R	http://dx.doi.org/10.1101/gr.GR1547R
DOI	10.1126/science.1218099	http://dx.doi.org/10.1126/science.1218099
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AK290126	http://www.ebi.ac.uk/ena/data/view/AK290126
EMBL	AL035304	http://www.ebi.ac.uk/ena/data/view/AL035304
EMBL	AL110297	http://www.ebi.ac.uk/ena/data/view/AL110297
EMBL	BC104157	http://www.ebi.ac.uk/ena/data/view/BC104157
EMBL	BC104158	http://www.ebi.ac.uk/ena/data/view/BC104158
EMBL	CH471067	http://www.ebi.ac.uk/ena/data/view/CH471067
EMBL	CR407632	http://www.ebi.ac.uk/ena/data/view/CR407632
EMBL	CR533473	http://www.ebi.ac.uk/ena/data/view/CR533473
EMBL	Z97876	http://www.ebi.ac.uk/ena/data/view/Z97876
Ensembl	ENST00000271373	http://www.ensembl.org/id/ENST00000271373
Ensembl	ENST00000367846	http://www.ensembl.org/id/ENST00000367846
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0050833	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050833
GO_process	GO:0035774	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035774
GO_process	GO:0061732	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061732
GO_process	GO:1902361	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902361
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0051186	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	MPC2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=MPC2
GeneID	25874	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25874
GeneTree	ENSGT00510000047120	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00510000047120
HGNC	HGNC:24515	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:24515
HOGENOM	HOG000188910	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000188910&db=HOGENOM6
HOVERGEN	HBG023934	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG023934&db=HOVERGEN
HPA	HPA056091	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA056091
InParanoid	O95563	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O95563
IntAct	O95563	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O95563*
InterPro	IPR005336	http://www.ebi.ac.uk/interpro/entry/IPR005336
Jabion	25874	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=25874
KEGG_Gene	hsa:25874	http://www.genome.jp/dbget-bin/www_bget?hsa:25874
MIM	614737	http://www.ncbi.nlm.nih.gov/omim/614737
MINT	MINT-3003059	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3003059
OMA	ASYHRIL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ASYHRIL
OrthoDB	EOG091G0XXH	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0XXH
PSORT	swissprot:MPC2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MPC2_HUMAN
PSORT-B	swissprot:MPC2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MPC2_HUMAN
PSORT2	swissprot:MPC2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MPC2_HUMAN
Pfam	PF03650	http://pfam.xfam.org/family/PF03650
PharmGKB	PA142672547	http://www.pharmgkb.org/do/serve?objId=PA142672547&objCls=Gene
Phobius	swissprot:MPC2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MPC2_HUMAN
PhylomeDB	O95563	http://phylomedb.org/?seqid=O95563
ProteinModelPortal	O95563	http://www.proteinmodelportal.org/query/uniprot/O95563
PubMed	11230166	http://www.ncbi.nlm.nih.gov/pubmed/11230166
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22628558	http://www.ncbi.nlm.nih.gov/pubmed/22628558
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-70268	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-70268
RefSeq	NP_001137146	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001137146
RefSeq	NP_056230	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_056230
RefSeq	XP_006711329	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006711329
STRING	9606.ENSP00000271373	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000271373&targetmode=cogs
TCDB	2.A.105.1	http://www.tcdb.org/search/result.php?tc=2.A.105.1
UCSC	uc001ges	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001ges&org=rat
UniGene	Hs.517768	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.517768
UniProtKB	MPC2_HUMAN	http://www.uniprot.org/uniprot/MPC2_HUMAN
UniProtKB-AC	O95563	http://www.uniprot.org/uniprot/O95563
charge	swissprot:MPC2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MPC2_HUMAN
eggNOG	ENOG4111UER	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111UER
eggNOG	KOG1589	http://eggnogapi.embl.de/nog_data/html/tree/KOG1589
epestfind	swissprot:MPC2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MPC2_HUMAN
garnier	swissprot:MPC2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MPC2_HUMAN
helixturnhelix	swissprot:MPC2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MPC2_HUMAN
hmoment	swissprot:MPC2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MPC2_HUMAN
iep	swissprot:MPC2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MPC2_HUMAN
inforesidue	swissprot:MPC2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MPC2_HUMAN
neXtProt	NX_O95563	http://www.nextprot.org/db/entry/NX_O95563
octanol	swissprot:MPC2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MPC2_HUMAN
pepcoil	swissprot:MPC2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MPC2_HUMAN
pepdigest	swissprot:MPC2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MPC2_HUMAN
pepinfo	swissprot:MPC2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MPC2_HUMAN
pepnet	swissprot:MPC2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MPC2_HUMAN
pepstats	swissprot:MPC2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MPC2_HUMAN
pepwheel	swissprot:MPC2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MPC2_HUMAN
pepwindow	swissprot:MPC2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MPC2_HUMAN
sigcleave	swissprot:MPC2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MPC2_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCMB2_HUMAN	BK channel subunit beta-2
# AltName	KCMB2_HUMAN	Calcium-activated potassium channel, subfamily M subunit beta-2
# AltName	KCMB2_HUMAN	Charybdotoxin receptor subunit beta-2
# AltName	KCMB2_HUMAN	Hbeta3
# AltName	KCMB2_HUMAN	K(VCA)beta-2
# AltName	KCMB2_HUMAN	Maxi K channel subunit beta-2
# AltName	KCMB2_HUMAN	Slo-beta-2
# DOMAIN	KCMB2_HUMAN	The ball and chain domain mediates the inactivation of KCNMA1. It occludes the conduction pathway of KCNMA1 channels, and comprises the pore-blocking ball domain (residues 1-17) and the chain domain (residues 20-45) linking it to the transmembrane segment. The ball domain is made up of a flexible N-terminus anchored at a well ordered loop-helix motif. The chain domain consists of a 4-turn helix with an unfolded linker at its C- terminus. {ECO 0000269|PubMed 10097176, ECO 0000269|PubMed 10377337}. 
# DrugBank	DB00721	Procaine
# DrugBank	DB01110	Miconazole
# Ensembl	ENST00000358316	ENSP00000351068; ENSG00000197584
# Ensembl	ENST00000420517	ENSP00000408252; ENSG00000197584
# Ensembl	ENST00000432997	ENSP00000407592; ENSG00000197584
# Ensembl	ENST00000452583	ENSP00000397483; ENSG00000197584
# ExpressionAtlas	Q9Y691	baseline and differential
# FUNCTION	KCMB2_HUMAN	Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons. {ECO 0000269|PubMed 10097176, ECO 0000269|PubMed 10377337}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IDA:UniProtKB.
# GO_function	GO:0008200	ion channel inhibitor activity; TAS:ProtInc.
# GO_function	GO:0015269	calcium-activated potassium channel activity; IDA:UniProtKB.
# GO_function	GO:0015459	potassium channel regulator activity; TAS:ProtInc.
# GO_process	GO:0001508	action potential; IDA:UniProtKB.
# GO_process	GO:0005513	detection of calcium ion; IDA:UniProtKB.
# GO_process	GO:0006813	potassium ion transport; IDA:UniProtKB.
# GO_process	GO:0007268	chemical synaptic transmission; IBA:GO_Central.
# GO_process	GO:0019228	neuronal action potential; IDA:UniProtKB.
# GO_process	GO:0019229	regulation of vasoconstriction; TAS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0003013	circulatory system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# Gene3D	4.10.81.20	-; 1.
# Genevisible	Q9Y691	HS
# HGNC	HGNC:6286	KCNMB2
# InterPro	IPR003930	K_chnl_Ca-activ_BK_bsu
# InterPro	IPR015382	KCNMB2_ball_chain_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04270	Vascular smooth muscle contraction
# MIM	605214	gene
# Organism	KCMB2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10258	PTHR10258
# PDB	1JO6	NMR; -; A=1-45
# PRINTS	PR01450	BKCHANNELB
# PTM	KCMB2_HUMAN	N-glycosylated. {ECO 0000269|PubMed 10792058}. 
# Pfam	PF03185	CaKB
# Pfam	PF09303	KcnmB2_inactiv
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-1296052	Ca2+ activated K+ channels
# Reactome	R-HSA-418457	cGMP effects
# RecName	KCMB2_HUMAN	Calcium-activated potassium channel subunit beta-2
# RefSeq	NP_001265840	NM_001278911.1
# RefSeq	NP_005823	NM_005832.4
# RefSeq	NP_852006	NM_181361.2
# RefSeq	XP_011510627	XM_011512325.2
# SIMILARITY	Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB2 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCMB2_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB2 per KCNMA1 tetramer. {ECO:0000269|PubMed	10097176}. 
# TCDB	8.A.14.1	the ca(2+)-activated k(+) channel auxiliary subunit slowpoke-Beta (sloBeta) family
# TISSUE SPECIFICITY	KCMB2_HUMAN	Expressed in kidney, heart and brain. Highly expressed in ovary. Expressed at low level in other tissues. {ECO 0000269|PubMed 10097176, ECO 0000269|PubMed 10377337, ECO 0000269|PubMed 10692449}. 
# UCSC	uc003fjd	human
# eggNOG	ENOG410IEU4	Eukaryota
# eggNOG	ENOG4111FIG	LUCA
BLAST	swissprot:KCMB2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCMB2_HUMAN
COXPRESdb	10242	http://coxpresdb.jp/data/gene/10242.shtml
CleanEx	HS_KCNMB2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNMB2
DOI	10.1073/pnas.100118597	http://dx.doi.org/10.1073/pnas.100118597
DOI	10.1073/pnas.96.7.4137	http://dx.doi.org/10.1073/pnas.96.7.4137
DOI	10.1074/jbc.275.9.6453	http://dx.doi.org/10.1074/jbc.275.9.6453
DOI	10.1074/jbc.M107118200	http://dx.doi.org/10.1074/jbc.M107118200
DOI	10.1085/jgp.20028667	http://dx.doi.org/10.1085/jgp.20028667
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1152/nips.01387.2002	http://dx.doi.org/10.1152/nips.01387.2002
DrugBank	DB00721	http://www.drugbank.ca/drugs/DB00721
DrugBank	DB01110	http://www.drugbank.ca/drugs/DB01110
EMBL	AF099137	http://www.ebi.ac.uk/ena/data/view/AF099137
EMBL	AF209747	http://www.ebi.ac.uk/ena/data/view/AF209747
EMBL	BC017825	http://www.ebi.ac.uk/ena/data/view/BC017825
Ensembl	ENST00000358316	http://www.ensembl.org/id/ENST00000358316
Ensembl	ENST00000420517	http://www.ensembl.org/id/ENST00000420517
Ensembl	ENST00000432997	http://www.ensembl.org/id/ENST00000432997
Ensembl	ENST00000452583	http://www.ensembl.org/id/ENST00000452583
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_function	GO:0008200	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008200
GO_function	GO:0015269	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015269
GO_function	GO:0015459	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015459
GO_process	GO:0001508	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001508
GO_process	GO:0005513	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005513
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0019228	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019228
GO_process	GO:0019229	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019229
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0003013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003013
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	4.10.81.20	http://www.cathdb.info/version/latest/superfamily/4.10.81.20
GeneCards	KCNMB2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNMB2
GeneID	10242	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10242
GeneTree	ENSGT00390000015997	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000015997
HGNC	HGNC:6286	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6286
HOVERGEN	HBG052223	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052223&db=HOVERGEN
HPA	CAB022649	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB022649
InParanoid	Q9Y691	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y691
IntAct	Q9Y691	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9Y691*
InterPro	IPR003930	http://www.ebi.ac.uk/interpro/entry/IPR003930
InterPro	IPR015382	http://www.ebi.ac.uk/interpro/entry/IPR015382
Jabion	10242	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10242
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:10242	http://www.genome.jp/dbget-bin/www_bget?hsa:10242
KEGG_Orthology	KO:K04938	http://www.genome.jp/dbget-bin/www_bget?KO:K04938
KEGG_Pathway	ko04270	http://www.genome.jp/kegg-bin/show_pathway?ko04270
MIM	605214	http://www.ncbi.nlm.nih.gov/omim/605214
MINT	MINT-8381989	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8381989
OMA	KMFIWTS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KMFIWTS
OrthoDB	EOG091G0MVO	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0MVO
PANTHER	PTHR10258	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10258
PDB	1JO6	http://www.ebi.ac.uk/pdbe-srv/view/entry/1JO6
PDBsum	1JO6	http://www.ebi.ac.uk/pdbsum/1JO6
PRINTS	PR01450	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01450
PSORT	swissprot:KCMB2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCMB2_HUMAN
PSORT-B	swissprot:KCMB2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCMB2_HUMAN
PSORT2	swissprot:KCMB2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCMB2_HUMAN
Pfam	PF03185	http://pfam.xfam.org/family/PF03185
Pfam	PF09303	http://pfam.xfam.org/family/PF09303
PharmGKB	PA30066	http://www.pharmgkb.org/do/serve?objId=PA30066&objCls=Gene
Phobius	swissprot:KCMB2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCMB2_HUMAN
PhylomeDB	Q9Y691	http://phylomedb.org/?seqid=Q9Y691
ProteinModelPortal	Q9Y691	http://www.proteinmodelportal.org/query/uniprot/Q9Y691
PubMed	10097176	http://www.ncbi.nlm.nih.gov/pubmed/10097176
PubMed	10377337	http://www.ncbi.nlm.nih.gov/pubmed/10377337
PubMed	10692449	http://www.ncbi.nlm.nih.gov/pubmed/10692449
PubMed	10792058	http://www.ncbi.nlm.nih.gov/pubmed/10792058
PubMed	11517232	http://www.ncbi.nlm.nih.gov/pubmed/11517232
PubMed	12136044	http://www.ncbi.nlm.nih.gov/pubmed/12136044
PubMed	12566540	http://www.ncbi.nlm.nih.gov/pubmed/12566540
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-1296052	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296052
Reactome	R-HSA-418457	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418457
RefSeq	NP_001265840	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001265840
RefSeq	NP_005823	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005823
RefSeq	NP_852006	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_852006
RefSeq	XP_011510627	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011510627
SMR	Q9Y691	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9Y691
STRING	9606.ENSP00000351068	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000351068&targetmode=cogs
TCDB	8.A.14.1	http://www.tcdb.org/search/result.php?tc=8.A.14.1
UCSC	uc003fjd	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003fjd&org=rat
UniGene	Hs.478368	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.478368
UniProtKB	KCMB2_HUMAN	http://www.uniprot.org/uniprot/KCMB2_HUMAN
UniProtKB-AC	Q9Y691	http://www.uniprot.org/uniprot/Q9Y691
charge	swissprot:KCMB2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCMB2_HUMAN
eggNOG	ENOG410IEU4	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IEU4
eggNOG	ENOG4111FIG	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111FIG
epestfind	swissprot:KCMB2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCMB2_HUMAN
garnier	swissprot:KCMB2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCMB2_HUMAN
helixturnhelix	swissprot:KCMB2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCMB2_HUMAN
hmoment	swissprot:KCMB2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCMB2_HUMAN
iep	swissprot:KCMB2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCMB2_HUMAN
inforesidue	swissprot:KCMB2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCMB2_HUMAN
neXtProt	NX_Q9Y691	http://www.nextprot.org/db/entry/NX_Q9Y691
octanol	swissprot:KCMB2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCMB2_HUMAN
pepcoil	swissprot:KCMB2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCMB2_HUMAN
pepdigest	swissprot:KCMB2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCMB2_HUMAN
pepinfo	swissprot:KCMB2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCMB2_HUMAN
pepnet	swissprot:KCMB2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCMB2_HUMAN
pepstats	swissprot:KCMB2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCMB2_HUMAN
pepwheel	swissprot:KCMB2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCMB2_HUMAN
pepwindow	swissprot:KCMB2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCMB2_HUMAN
sigcleave	swissprot:KCMB2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCMB2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AZIN2_HUMAN	Event=Alternative splicing; Named isoforms=5; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q96A70-1; Sequence=Displayed; Name=2; IsoId=Q96A70-2; Sequence=VSP_003756; Name=3; IsoId=Q96A70-3; Sequence=VSP_003757, VSP_003758; Name=4; IsoId=Q96A70-4; Sequence=VSP_003755, VSP_003757, VSP_003758; Name=6; IsoId=Q96A70-5; Sequence=VSP_003754, VSP_003757, VSP_003758; 
# AltName	AZIN2_HUMAN	Arginine decarboxylase
# AltName	AZIN2_HUMAN	Ornithine decarboxylase-like protein
# AltName	AZIN2_HUMAN	ornithine decarboxylase paralog
# BRENDA	4.1.1.17	2681
# BRENDA	4.1.1.19	2681
# BioGrid	125246	10
# CAUTION	AZIN2_HUMAN	Was initially reported to have ornithine decarboxylase (PubMed 11587527) or arginine decarboxylase (PubMed 14738999) activities, but it was later found that the mouse ortholog does not possess either of them. {ECO 0000305|PubMed 11587527, ECO 0000305|PubMed 14738999}.
# CCDS	CCDS375	-. [Q96A70-1]
# CCDS	CCDS76138	-. [Q96A70-2]
# DOMAIN	AZIN2_HUMAN	The N-terminus domain is necessary for its localization to the ER-Golgi intermediate compartment (ERGIC). {ECO 0000250}. 
# DrugBank	DB00125	L-Arginine
# Ensembl	ENST00000294517	ENSP00000294517; ENSG00000142920. [Q96A70-1]
# Ensembl	ENST00000373440	ENSP00000362539; ENSG00000142920. [Q96A70-5]
# Ensembl	ENST00000373441	ENSP00000362540; ENSG00000142920. [Q96A70-2]
# Ensembl	ENST00000373443	ENSP00000362542; ENSG00000142920. [Q96A70-1]
# FUNCTION	AZIN2_HUMAN	Antizyme inhibitor protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake by counteracting the negative effect of antizymes OAZ1, OAZ2 and OAZ3 on ODC1 activity (PubMed 17900240). Inhibits antizyme-dependent ODC1 degradation by binding to antizymes. Releases ODC1 from its inactive complex with antizymes, leading to formation of the catalytically active ODC1. Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking (PubMed 20188728). {ECO 0000269|PubMed 14738999, ECO 0000269|PubMed 17900240, ECO 0000269|PubMed 20188728}. 
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005739	mitochondrion; IEA:Ensembl.
# GO_component	GO:0005801	cis-Golgi network; ISS:UniProtKB.
# GO_component	GO:0005802	trans-Golgi network; IDA:UniProtKB.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0030133	transport vesicle; IMP:UniProtKB.
# GO_component	GO:0030424	axon; IDA:UniProtKB.
# GO_component	GO:0030425	dendrite; IDA:UniProtKB.
# GO_component	GO:0031410	cytoplasmic vesicle; IDA:UniProtKB.
# GO_component	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane; ISS:UniProtKB.
# GO_component	GO:0043204	perikaryon; IDA:UniProtKB.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IDA:UniProtKB.
# GO_component	GO:1990005	granular vesicle; IDA:UniProtKB.
# GO_function	GO:0008792	arginine decarboxylase activity; TAS:Reactome.
# GO_function	GO:0015489	putrescine transmembrane transporter activity; ISS:UniProtKB.
# GO_function	GO:0042978	ornithine decarboxylase activator activity; IDA:UniProtKB.
# GO_process	GO:0007283	spermatogenesis; NAS:UniProtKB.
# GO_process	GO:0015847	putrescine transport; ISS:UniProtKB.
# GO_process	GO:0033387	putrescine biosynthetic process from ornithine; IBA:GO_Central.
# GO_process	GO:0042177	negative regulation of protein catabolic process; IDA:UniProtKB.
# GO_process	GO:0043085	positive regulation of catalytic activity; ISS:UniProtKB.
# GO_process	GO:0097055	agmatine biosynthetic process; TAS:Reactome.
# GO_process	GO:0098629	trans-Golgi network membrane organization; IMP:UniProtKB.
# GO_process	GO:1902269	positive regulation of polyamine transmembrane transport; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0016829	lyase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0030234	enzyme regulator activity
# GOslim_process	GO:0006520	cellular amino acid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0061024	membrane organization
# Gene3D	2.40.37.10	-; 1.
# Gene3D	3.20.20.10	-; 1.
# Genevisible	Q96A70	HS
# HGNC	HGNC:29957	AZIN2
# INTERACTION	AZIN2_HUMAN	Q9UMX2 OAZ3; NbExp=5; IntAct=EBI-10281609, EBI-10281601; Q9UMX2-2 OAZ3; NbExp=4; IntAct=EBI-10281609, EBI-12049527; 
# InterPro	IPR000183	Orn/DAP/Arg_de-COase
# InterPro	IPR002433	Orn_de-COase
# InterPro	IPR009006	Ala_racemase/Decarboxylase_C
# InterPro	IPR022643	De-COase2_C
# InterPro	IPR022644	De-COase2_N
# InterPro	IPR022653	De-COase2_pyr-phos_BS
# InterPro	IPR022657	De-COase2_CS
# InterPro	IPR029066	PLP-binding_barrel
# InterPro	IPR031173	Azin2
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00330	Arginine and proline metabolism
# MIM	608353	gene
# Organism	AZIN2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11482:SF4	PTHR11482:SF4
# PRINTS	PR01179	ODADCRBXLASE
# PRINTS	PR01182	ORNDCRBXLASE
# PROSITE	PS00878	ODR_DC_2_1
# PROSITE	PS00879	ODR_DC_2_2
# PTM	AZIN2_HUMAN	Ubiquitinated, leading to its proteosomal degradation; a process that is reduced in presence of antizymes. May also be degraded through the lysosomal degradative pathway in a proteosomal-independent manner. {ECO 0000269|PubMed 17900240}. 
# Pfam	PF00278	Orn_DAP_Arg_deC
# Pfam	PF02784	Orn_Arg_deC_N
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-351143	Agmatine biosynthesis
# RecName	AZIN2_HUMAN	Antizyme inhibitor 2
# RefSeq	NP_001280491	NM_001293562.1. [Q96A70-1]
# RefSeq	NP_001288752	NM_001301823.1
# RefSeq	NP_001288753	NM_001301824.1
# RefSeq	NP_001288754	NM_001301825.1. [Q96A70-2]
# RefSeq	NP_001288755	NM_001301826.1. [Q96A70-3]
# RefSeq	NP_443724	NM_052998.3. [Q96A70-1]
# RefSeq	XP_005270461	XM_005270404.2. [Q96A70-1]
# RefSeq	XP_005270464	XM_005270407.1
# RefSeq	XP_011538865	XM_011540563.1. [Q96A70-3]
# RefSeq	XP_016855657	XM_017000168.1
# RefSeq	XP_016855658	XM_017000169.1
# RefSeq	XP_016855659	XM_017000170.1
# RefSeq	XP_016855660	XM_017000171.1
# RefSeq	XP_016855661	XM_017000172.1
# RefSeq	XP_016855662	XM_017000173.1
# RefSeq	XP_016855664	XM_017000175.1
# SIMILARITY	Belongs to the Orn/Lys/Arg decarboxylase class-II family. ODC antizyme inhibitor subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	AZIN2_HUMAN	Nucleus. Cytoplasm {ECO 0000250}. Cytoplasm, perinuclear region. Membrane {ECO 0000250}. Cytoplasmic vesicle. Endoplasmic reticulum-Golgi intermediate compartment {ECO 0000250}. Golgi apparatus, cis-Golgi network {ECO 0000250}. Golgi apparatus, trans-Golgi network. Cytoplasmic granule. Cell projection, axon. Cell projection, dendrite. Perikaryon. Note=Colocalizes with KDEL receptors in ER-Golgi intermediate compartment (ERGIC). Translocates from the ERGIC structure to the cytoplasm in an antizyme-dependent manner. Localizes with vesicle- associated membrane protein VAMP8 in the vicinity of the plasma membrane within serotonin-containing secretory granules (By similarity). Detected as vesicle-like pattern in neurite outgrowths. Localizes to the vesicular compartments of the secretory pathway, predominantly in the trans-Golgi network (TGN). Localizes with vesicle-associated membrane protein VAMP8 in the vicinity of the plasma membrane within serotonin-containing secretory granules. {ECO 0000250}. 
# SUBUNIT	Interacts with OAZ1, OAZ2 and OAZ3; the interactions stabilize the complex by inhibiting AZIN2 ubiquitination and degradation. Does not form a heterodimer with ODC1 (By similarity). Monomer. Interaction with OAZ1, OAZ2 and OAZ3; the interactions lead to increased ornithine decarboxylase (ODC) activity and decreased rate of ODC1 degradation. {ECO:0000250, ECO	0000269|PubMed:17900240}. 
# SUPFAM	SSF50621	SSF50621
# SUPFAM	SSF51419	SSF51419
# TISSUE SPECIFICITY	AZIN2_HUMAN	Expressed in the neocortex, thalamus, hippocampus, cerebellum, medulla oblongata, gray and white matter. Expressed in neurons, oligodendrocytes, basket, Purkinje and pyramidal cells. Expressed in spermatocytes and Leydig cells of the testis. Expressed in luteal theca cells lining corpus luteum cysts and in hilus cells of the ovary. Expressed in primary and neoplastic mast cells (MC) (at protein level). Highly expressed in brain. Also expressed in testis. {ECO 0000269|PubMed 11587527, ECO 0000269|PubMed 14738999, ECO 0000269|PubMed 19718454, ECO 0000269|PubMed 19756694, ECO 0000269|PubMed 19832840}. 
# UCSC	uc001bwr	human. [Q96A70-1]
# eggNOG	COG0019	LUCA
# eggNOG	KOG0622	Eukaryota
BLAST	swissprot:AZIN2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AZIN2_HUMAN
BioCyc	MetaCyc:HS06971-MONOMER	http://biocyc.org/getid?id=MetaCyc:HS06971-MONOMER
BioCyc	ZFISH:HS06971-MONOMER	http://biocyc.org/getid?id=ZFISH:HS06971-MONOMER
COXPRESdb	113451	http://coxpresdb.jp/data/gene/113451.shtml
DOI	10.1006/bbrc.2001.5703	http://dx.doi.org/10.1006/bbrc.2001.5703
DOI	10.1007/s00418-009-0636-7	http://dx.doi.org/10.1007/s00418-009-0636-7
DOI	10.1007/s00726-009-0419-4	http://dx.doi.org/10.1007/s00726-009-0419-4
DOI	10.1016/j.bbagen.2003.11.006	http://dx.doi.org/10.1016/j.bbagen.2003.11.006
DOI	10.1016/j.yexcr.2010.02.021	http://dx.doi.org/10.1016/j.yexcr.2010.02.021
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/BJ20071004	http://dx.doi.org/10.1042/BJ20071004
DOI	10.1093/dnares/8.6.319	http://dx.doi.org/10.1093/dnares/8.6.319
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1750-3639.2009.00334.x	http://dx.doi.org/10.1111/j.1750-3639.2009.00334.x
DOI	10.1371/journal.pone.0006858	http://dx.doi.org/10.1371/journal.pone.0006858
DrugBank	DB00125	http://www.drugbank.ca/drugs/DB00125
EMBL	AB075825	http://www.ebi.ac.uk/ena/data/view/AB075825
EMBL	AK057051	http://www.ebi.ac.uk/ena/data/view/AK057051
EMBL	AK095127	http://www.ebi.ac.uk/ena/data/view/AK095127
EMBL	AK315677	http://www.ebi.ac.uk/ena/data/view/AK315677
EMBL	AL020995	http://www.ebi.ac.uk/ena/data/view/AL020995
EMBL	AL020995	http://www.ebi.ac.uk/ena/data/view/AL020995
EMBL	AL020995	http://www.ebi.ac.uk/ena/data/view/AL020995
EMBL	AY050634	http://www.ebi.ac.uk/ena/data/view/AY050634
EMBL	AY050635	http://www.ebi.ac.uk/ena/data/view/AY050635
EMBL	AY050636	http://www.ebi.ac.uk/ena/data/view/AY050636
EMBL	AY050637	http://www.ebi.ac.uk/ena/data/view/AY050637
EMBL	AY050638	http://www.ebi.ac.uk/ena/data/view/AY050638
EMBL	AY325129	http://www.ebi.ac.uk/ena/data/view/AY325129
EMBL	BC010449	http://www.ebi.ac.uk/ena/data/view/BC010449
EMBL	BC028128	http://www.ebi.ac.uk/ena/data/view/BC028128
EMBL	CH471059	http://www.ebi.ac.uk/ena/data/view/CH471059
EMBL	CH471059	http://www.ebi.ac.uk/ena/data/view/CH471059
Ensembl	ENST00000294517	http://www.ensembl.org/id/ENST00000294517
Ensembl	ENST00000373440	http://www.ensembl.org/id/ENST00000373440
Ensembl	ENST00000373441	http://www.ensembl.org/id/ENST00000373441
Ensembl	ENST00000373443	http://www.ensembl.org/id/ENST00000373443
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005801	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005801
GO_component	GO:0005802	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005802
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0030133	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030133
GO_component	GO:0030424	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030424
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GO_component	GO:0033116	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033116
GO_component	GO:0043204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043204
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_component	GO:1990005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990005
GO_function	GO:0008792	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008792
GO_function	GO:0015489	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015489
GO_function	GO:0042978	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042978
GO_process	GO:0007283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007283
GO_process	GO:0015847	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015847
GO_process	GO:0033387	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033387
GO_process	GO:0042177	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042177
GO_process	GO:0043085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043085
GO_process	GO:0097055	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097055
GO_process	GO:0098629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098629
GO_process	GO:1902269	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902269
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0016829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0030234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234
GOslim_process	GO:0006520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
Gene3D	2.40.37.10	http://www.cathdb.info/version/latest/superfamily/2.40.37.10
Gene3D	3.20.20.10	http://www.cathdb.info/version/latest/superfamily/3.20.20.10
GeneCards	AZIN2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=AZIN2
GeneID	113451	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=113451
GeneTree	ENSGT00390000011560	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000011560
HGNC	HGNC:29957	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:29957
HOVERGEN	HBG005456	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG005456&db=HOVERGEN
HPA	HPA028045	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA028045
HPA	HPA028527	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA028527
InParanoid	Q96A70	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96A70
IntAct	Q96A70	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96A70*
InterPro	IPR000183	http://www.ebi.ac.uk/interpro/entry/IPR000183
InterPro	IPR002433	http://www.ebi.ac.uk/interpro/entry/IPR002433
InterPro	IPR009006	http://www.ebi.ac.uk/interpro/entry/IPR009006
InterPro	IPR022643	http://www.ebi.ac.uk/interpro/entry/IPR022643
InterPro	IPR022644	http://www.ebi.ac.uk/interpro/entry/IPR022644
InterPro	IPR022653	http://www.ebi.ac.uk/interpro/entry/IPR022653
InterPro	IPR022657	http://www.ebi.ac.uk/interpro/entry/IPR022657
InterPro	IPR029066	http://www.ebi.ac.uk/interpro/entry/IPR029066
InterPro	IPR031173	http://www.ebi.ac.uk/interpro/entry/IPR031173
Jabion	113451	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=113451
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:113451	http://www.genome.jp/dbget-bin/www_bget?hsa:113451
KEGG_Orthology	KO:K01583	http://www.genome.jp/dbget-bin/www_bget?KO:K01583
KEGG_Pathway	ko00330	http://www.genome.jp/kegg-bin/show_pathway?ko00330
KEGG_Reaction	rn:R00566	http://www.genome.jp/dbget-bin/www_bget?rn:R00566
MIM	608353	http://www.ncbi.nlm.nih.gov/omim/608353
OMA	SHMEVVG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SHMEVVG
OrthoDB	EOG091G0AJV	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0AJV
PANTHER	PTHR11482:SF4	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11482:SF4
PRINTS	PR01179	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01179
PRINTS	PR01182	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01182
PROSITE	PS00878	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00878
PROSITE	PS00879	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00879
PSORT	swissprot:AZIN2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AZIN2_HUMAN
PSORT-B	swissprot:AZIN2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AZIN2_HUMAN
PSORT2	swissprot:AZIN2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AZIN2_HUMAN
Pfam	PF00278	http://pfam.xfam.org/family/PF00278
Pfam	PF02784	http://pfam.xfam.org/family/PF02784
PharmGKB	PA142672642	http://www.pharmgkb.org/do/serve?objId=PA142672642&objCls=Gene
Phobius	swissprot:AZIN2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AZIN2_HUMAN
PhylomeDB	Q96A70	http://phylomedb.org/?seqid=Q96A70
ProteinModelPortal	Q96A70	http://www.proteinmodelportal.org/query/uniprot/Q96A70
PubMed	11587527	http://www.ncbi.nlm.nih.gov/pubmed/11587527
PubMed	11853319	http://www.ncbi.nlm.nih.gov/pubmed/11853319
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	14738999	http://www.ncbi.nlm.nih.gov/pubmed/14738999
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17900240	http://www.ncbi.nlm.nih.gov/pubmed/17900240
PubMed	19718454	http://www.ncbi.nlm.nih.gov/pubmed/19718454
PubMed	19756694	http://www.ncbi.nlm.nih.gov/pubmed/19756694
PubMed	19832840	http://www.ncbi.nlm.nih.gov/pubmed/19832840
PubMed	19956990	http://www.ncbi.nlm.nih.gov/pubmed/19956990
PubMed	20188728	http://www.ncbi.nlm.nih.gov/pubmed/20188728
Reactome	R-HSA-351143	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-351143
RefSeq	NP_001280491	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001280491
RefSeq	NP_001288752	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001288752
RefSeq	NP_001288753	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001288753
RefSeq	NP_001288754	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001288754
RefSeq	NP_001288755	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001288755
RefSeq	NP_443724	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_443724
RefSeq	XP_005270461	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005270461
RefSeq	XP_005270464	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005270464
RefSeq	XP_011538865	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011538865
RefSeq	XP_016855657	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016855657
RefSeq	XP_016855658	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016855658
RefSeq	XP_016855659	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016855659
RefSeq	XP_016855660	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016855660
RefSeq	XP_016855661	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016855661
RefSeq	XP_016855662	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016855662
RefSeq	XP_016855664	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016855664
SMR	Q96A70	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q96A70
STRING	9606.ENSP00000294517	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000294517&targetmode=cogs
SUPFAM	SSF50621	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50621
SUPFAM	SSF51419	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51419
UCSC	uc001bwr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001bwr&org=rat
UniGene	Hs.101807	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.101807
UniProtKB	AZIN2_HUMAN	http://www.uniprot.org/uniprot/AZIN2_HUMAN
UniProtKB-AC	Q96A70	http://www.uniprot.org/uniprot/Q96A70
charge	swissprot:AZIN2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AZIN2_HUMAN
eggNOG	COG0019	http://eggnogapi.embl.de/nog_data/html/tree/COG0019
eggNOG	KOG0622	http://eggnogapi.embl.de/nog_data/html/tree/KOG0622
epestfind	swissprot:AZIN2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AZIN2_HUMAN
garnier	swissprot:AZIN2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AZIN2_HUMAN
helixturnhelix	swissprot:AZIN2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AZIN2_HUMAN
hmoment	swissprot:AZIN2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AZIN2_HUMAN
iep	swissprot:AZIN2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AZIN2_HUMAN
inforesidue	swissprot:AZIN2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AZIN2_HUMAN
neXtProt	NX_Q96A70	http://www.nextprot.org/db/entry/NX_Q96A70
octanol	swissprot:AZIN2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AZIN2_HUMAN
pepcoil	swissprot:AZIN2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AZIN2_HUMAN
pepdigest	swissprot:AZIN2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AZIN2_HUMAN
pepinfo	swissprot:AZIN2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AZIN2_HUMAN
pepnet	swissprot:AZIN2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AZIN2_HUMAN
pepstats	swissprot:AZIN2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AZIN2_HUMAN
pepwheel	swissprot:AZIN2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AZIN2_HUMAN
pepwindow	swissprot:AZIN2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AZIN2_HUMAN
sigcleave	swissprot:AZIN2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AZIN2_HUMAN
## Database	ID	URL or Descriptions
# AltName	CLCN1_HUMAN	Chloride channel protein, skeletal muscle
# BioGrid	107594	7
# ChiTaRS	CLCN1	human
# DISEASE	CLCN1_HUMAN	Myotonia congenita, autosomal dominant (MCAD) [MIM 160800]  A non-dystrophic skeletal muscle disorder characterized by muscle stiffness and an inability of the muscle to relax after voluntary contraction. Most patients have symptom onset in the legs, which later progresses to the arms, neck, and facial muscles. Many patients show marked hypertrophy of the lower limb muscles. The autosomal dominant form (Thomsen disease) is less common and less severe than the autosomal recessive one (Becker disease). A milder form of autosomal dominant myotonia is characterized by isolated myotonia without muscle weakness, hypotrophy, or hypertrophy (myotonia levior). {ECO 0000269|PubMed 12661046, ECO 0000269|PubMed 7581380, ECO 0000269|PubMed 7981750, ECO 0000269|PubMed 8112288, ECO 0000269|PubMed 8533761, ECO 0000269|PubMed 9122265, ECO 0000269|PubMed 9566422, ECO 0000269|PubMed 9736777}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CLCN1_HUMAN	Myotonia congenita, autosomal recessive (MCAR) [MIM 255700]  A non-dystrophic skeletal muscle disorder characterized by muscle stiffness and an inability of the muscle to relax after voluntary contraction. Most patients have symptom onset in the legs, which later progresses to the arms, neck, and facial muscles. Many patients show marked hypertrophy of the lower limb muscles. The autosomal recessive form (Becker disease) is more severe than the autosomal dominant one (Thomsen disease). {ECO 0000269|PubMed 10215406, ECO 0000269|PubMed 10644771, ECO 0000269|PubMed 11113225, ECO 0000269|PubMed 12661046, ECO 0000269|PubMed 1379744, ECO 0000269|PubMed 19697366, ECO 0000269|PubMed 22521272, ECO 0000269|PubMed 26007199, ECO 0000269|PubMed 26502825, ECO 0000269|PubMed 26510092, ECO 0000269|PubMed 7874130, ECO 0000269|PubMed 7951242, ECO 0000269|PubMed 7981681, ECO 0000269|PubMed 8571958, ECO 0000269|PubMed 9566422, ECO 0000269|PubMed 9736777}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000343257	ENSP00000339867; ENSG00000188037
# ExpressionAtlas	P35523	baseline and differential
# FUNCTION	CLCN1_HUMAN	Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. {ECO 0000269|PubMed 12456816, ECO 0000269|PubMed 22521272, ECO 0000269|PubMed 26007199, ECO 0000269|PubMed 26502825, ECO 0000269|PubMed 26510092, ECO 0000269|PubMed 7951242, ECO 0000269|PubMed 8112288, ECO 0000269|PubMed 9122265, ECO 0000269|PubMed 9736777}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0042383	sarcolemma; IEA:Ensembl.
# GO_function	GO:0005247	voltage-gated chloride channel activity; IMP:UniProtKB.
# GO_function	GO:0031404	chloride ion binding; IBA:GO_Central.
# GO_function	GO:0042803	protein homodimerization activity; IDA:UniProtKB.
# GO_process	GO:0006936	muscle contraction; IMP:UniProtKB.
# GO_process	GO:0019227	neuronal action potential propagation; IEA:Ensembl.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:1902476	chloride transmembrane transport; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.10.3080.10	-; 1.
# Genevisible	P35523	HS
# HGNC	HGNC:2019	CLCN1
# INTERACTION	CLCN1_HUMAN	Q92624 APPBP2; NbExp=5; IntAct=EBI-10206780, EBI-743771; Q8IZU0 FAM9B; NbExp=3; IntAct=EBI-10206780, EBI-10175124; 
# IntAct	P35523	2
# InterPro	IPR000644	CBS_dom
# InterPro	IPR001807	Cl-channel_volt-gated
# InterPro	IPR002243	Cl_channel-1
# InterPro	IPR014743	Cl-channel_core
# KEGG_Brite	ko04040	Ion channels
# KEGG_Disease	H00705	[Musculoskeletal disease; Nervous system disease] Myotonia levoir
# MIM	118425	gene
# MIM	160800	phenotype
# MIM	255700	phenotype
# MISCELLANEOUS	CLCN1_HUMAN	The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels. 
# Organism	CLCN1_HUMAN	Homo sapiens (Human)
# Orphanet	614	Thomsen and Becker disease
# PIR	S37078	S37078
# PRINTS	PR00762	CLCHANNEL
# PRINTS	PR01112	CLCHANNEL1
# PROSITE	PS51371	CBS; 2
# Pfam	PF00654	Voltage_CLC
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	CLCN1_HUMAN	Chloride channel protein 1
# RefSeq	NP_000074	NM_000083.2
# SIMILARITY	Belongs to the chloride channel (TC 2.A.49) family. ClC-1/CLCN1 subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 2 CBS domains. {ECO:0000255|PROSITE- ProRule	PRU00703}.
# SUBCELLULAR LOCATION	CLCN1_HUMAN	Cell membrane {ECO 0000269|PubMed 26502825}; Multi-pass membrane protein {ECO 0000255}. 
# SUBUNIT	Homodimer. {ECO:0000269|PubMed	26502825}. 
# SUPFAM	SSF81340	SSF81340
# TCDB	2.A.49.2	the chloride carrier/channel (clc) family
# TISSUE SPECIFICITY	CLCN1_HUMAN	Predominantly expressed in skeletal muscles. 
# UCSC	uc003wcr	human
# eggNOG	COG0038	LUCA
# eggNOG	KOG0476	Eukaryota
BLAST	swissprot:CLCN1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CLCN1_HUMAN
BioCyc	ZFISH:G66-31329-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31329-MONOMER
COXPRESdb	1180	http://coxpresdb.jp/data/gene/1180.shtml
CleanEx	HS_CLCN1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CLCN1
DOI	10.1002/(SICI)1098-1004(1998)11:4<331::AID-HUMU13>3.3.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1998)11:4<331::AID-HUMU13>3.3.CO
DOI	10.1002/humu.22916	http://dx.doi.org/10.1002/humu.22916
DOI	10.1002/mus.10347	http://dx.doi.org/10.1002/mus.10347
DOI	10.1002/mus.21525	http://dx.doi.org/10.1002/mus.21525
DOI	10.1007/s12017-015-8356-8	http://dx.doi.org/10.1007/s12017-015-8356-8
DOI	10.1016/0896-6273(95)90023-3	http://dx.doi.org/10.1016/0896-6273(95)90023-3
DOI	10.1016/j.jns.2012.03.024	http://dx.doi.org/10.1016/j.jns.2012.03.024
DOI	10.1038/ng0493-305	http://dx.doi.org/10.1038/ng0493-305
DOI	10.1038/srep15382	http://dx.doi.org/10.1038/srep15382
DOI	10.1073/pnas.94.6.2729	http://dx.doi.org/10.1073/pnas.94.6.2729
DOI	10.1074/jbc.275.4.2999	http://dx.doi.org/10.1074/jbc.275.4.2999
DOI	10.1093/hmg/3.6.941	http://dx.doi.org/10.1093/hmg/3.6.941
DOI	10.1093/hmg/3.7.1123	http://dx.doi.org/10.1093/hmg/3.7.1123
DOI	10.1093/hmg/4.8.1397	http://dx.doi.org/10.1093/hmg/4.8.1397
DOI	10.1093/hmg/7.11.1753	http://dx.doi.org/10.1093/hmg/7.11.1753
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1113/JP270358	http://dx.doi.org/10.1113/JP270358
DOI	10.1113/jphysiol.2002.027037	http://dx.doi.org/10.1113/jphysiol.2002.027037
DOI	10.1113/jphysiol.2012.232785	http://dx.doi.org/10.1113/jphysiol.2012.232785
DOI	10.1126/science.1083423	http://dx.doi.org/10.1126/science.1083423
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1126/science.1379744	http://dx.doi.org/10.1126/science.1379744
DOI	10.1212/WNL.50.4.1176	http://dx.doi.org/10.1212/WNL.50.4.1176
DOI	10.1212/WNL.55.11.1697	http://dx.doi.org/10.1212/WNL.55.11.1697
EMBL	BC112156	http://www.ebi.ac.uk/ena/data/view/BC112156
EMBL	BC113495	http://www.ebi.ac.uk/ena/data/view/BC113495
EMBL	CH236959	http://www.ebi.ac.uk/ena/data/view/CH236959
EMBL	L08261	http://www.ebi.ac.uk/ena/data/view/L08261
EMBL	L08262	http://www.ebi.ac.uk/ena/data/view/L08262
EMBL	L08263	http://www.ebi.ac.uk/ena/data/view/L08263
EMBL	L08264	http://www.ebi.ac.uk/ena/data/view/L08264
EMBL	L08265	http://www.ebi.ac.uk/ena/data/view/L08265
EMBL	M97820	http://www.ebi.ac.uk/ena/data/view/M97820
EMBL	Z25587	http://www.ebi.ac.uk/ena/data/view/Z25587
EMBL	Z25752	http://www.ebi.ac.uk/ena/data/view/Z25752
EMBL	Z25753	http://www.ebi.ac.uk/ena/data/view/Z25753
EMBL	Z25754	http://www.ebi.ac.uk/ena/data/view/Z25754
EMBL	Z25755	http://www.ebi.ac.uk/ena/data/view/Z25755
EMBL	Z25756	http://www.ebi.ac.uk/ena/data/view/Z25756
EMBL	Z25757	http://www.ebi.ac.uk/ena/data/view/Z25757
EMBL	Z25758	http://www.ebi.ac.uk/ena/data/view/Z25758
EMBL	Z25759	http://www.ebi.ac.uk/ena/data/view/Z25759
EMBL	Z25760	http://www.ebi.ac.uk/ena/data/view/Z25760
EMBL	Z25761	http://www.ebi.ac.uk/ena/data/view/Z25761
EMBL	Z25762	http://www.ebi.ac.uk/ena/data/view/Z25762
EMBL	Z25763	http://www.ebi.ac.uk/ena/data/view/Z25763
EMBL	Z25764	http://www.ebi.ac.uk/ena/data/view/Z25764
EMBL	Z25765	http://www.ebi.ac.uk/ena/data/view/Z25765
EMBL	Z25766	http://www.ebi.ac.uk/ena/data/view/Z25766
EMBL	Z25767	http://www.ebi.ac.uk/ena/data/view/Z25767
EMBL	Z25768	http://www.ebi.ac.uk/ena/data/view/Z25768
EMBL	Z25872	http://www.ebi.ac.uk/ena/data/view/Z25872
EMBL	Z25884	http://www.ebi.ac.uk/ena/data/view/Z25884
Ensembl	ENST00000343257	http://www.ensembl.org/id/ENST00000343257
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0042383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042383
GO_function	GO:0005247	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005247
GO_function	GO:0031404	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031404
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_process	GO:0006936	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006936
GO_process	GO:0019227	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019227
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.10.3080.10	http://www.cathdb.info/version/latest/superfamily/1.10.3080.10
GeneCards	CLCN1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CLCN1
GeneID	1180	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1180
GeneTree	ENSGT00760000119109	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119109
HGNC	HGNC:2019	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2019
HOGENOM	HOG000231297	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231297&db=HOGENOM6
HOVERGEN	HBG005332	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG005332&db=HOVERGEN
InParanoid	P35523	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P35523
IntAct	P35523	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P35523*
InterPro	IPR000644	http://www.ebi.ac.uk/interpro/entry/IPR000644
InterPro	IPR001807	http://www.ebi.ac.uk/interpro/entry/IPR001807
InterPro	IPR002243	http://www.ebi.ac.uk/interpro/entry/IPR002243
InterPro	IPR014743	http://www.ebi.ac.uk/interpro/entry/IPR014743
Jabion	1180	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1180
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00705	http://www.genome.jp/dbget-bin/www_bget?H00705
KEGG_Gene	hsa:1180	http://www.genome.jp/dbget-bin/www_bget?hsa:1180
KEGG_Orthology	KO:K05010	http://www.genome.jp/dbget-bin/www_bget?KO:K05010
MIM	118425	http://www.ncbi.nlm.nih.gov/omim/118425
MIM	160800	http://www.ncbi.nlm.nih.gov/omim/160800
MIM	255700	http://www.ncbi.nlm.nih.gov/omim/255700
OMA	DMLTVGC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DMLTVGC
Orphanet	614	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=614
OrthoDB	EOG091G01RJ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01RJ
PRINTS	PR00762	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00762
PRINTS	PR01112	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01112
PROSITE	PS51371	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51371
PSORT	swissprot:CLCN1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CLCN1_HUMAN
PSORT-B	swissprot:CLCN1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CLCN1_HUMAN
PSORT2	swissprot:CLCN1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CLCN1_HUMAN
Pfam	PF00654	http://pfam.xfam.org/family/PF00654
PharmGKB	PA26546	http://www.pharmgkb.org/do/serve?objId=PA26546&objCls=Gene
Phobius	swissprot:CLCN1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CLCN1_HUMAN
PhylomeDB	P35523	http://phylomedb.org/?seqid=P35523
ProteinModelPortal	P35523	http://www.proteinmodelportal.org/query/uniprot/P35523
PubMed	10215406	http://www.ncbi.nlm.nih.gov/pubmed/10215406
PubMed	10644771	http://www.ncbi.nlm.nih.gov/pubmed/10644771
PubMed	11113225	http://www.ncbi.nlm.nih.gov/pubmed/11113225
PubMed	12456816	http://www.ncbi.nlm.nih.gov/pubmed/12456816
PubMed	12661046	http://www.ncbi.nlm.nih.gov/pubmed/12661046
PubMed	12690205	http://www.ncbi.nlm.nih.gov/pubmed/12690205
PubMed	1379744	http://www.ncbi.nlm.nih.gov/pubmed/1379744
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	19697366	http://www.ncbi.nlm.nih.gov/pubmed/19697366
PubMed	22521272	http://www.ncbi.nlm.nih.gov/pubmed/22521272
PubMed	22641783	http://www.ncbi.nlm.nih.gov/pubmed/22641783
PubMed	26007199	http://www.ncbi.nlm.nih.gov/pubmed/26007199
PubMed	26096614	http://www.ncbi.nlm.nih.gov/pubmed/26096614
PubMed	26502825	http://www.ncbi.nlm.nih.gov/pubmed/26502825
PubMed	26510092	http://www.ncbi.nlm.nih.gov/pubmed/26510092
PubMed	7581380	http://www.ncbi.nlm.nih.gov/pubmed/7581380
PubMed	7874130	http://www.ncbi.nlm.nih.gov/pubmed/7874130
PubMed	7951242	http://www.ncbi.nlm.nih.gov/pubmed/7951242
PubMed	7981681	http://www.ncbi.nlm.nih.gov/pubmed/7981681
PubMed	7981750	http://www.ncbi.nlm.nih.gov/pubmed/7981750
PubMed	8112288	http://www.ncbi.nlm.nih.gov/pubmed/8112288
PubMed	8533761	http://www.ncbi.nlm.nih.gov/pubmed/8533761
PubMed	8571958	http://www.ncbi.nlm.nih.gov/pubmed/8571958
PubMed	8845168	http://www.ncbi.nlm.nih.gov/pubmed/8845168
PubMed	9122265	http://www.ncbi.nlm.nih.gov/pubmed/9122265
PubMed	9566422	http://www.ncbi.nlm.nih.gov/pubmed/9566422
PubMed	9736777	http://www.ncbi.nlm.nih.gov/pubmed/9736777
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_000074	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000074
STRING	9606.ENSP00000339867	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000339867&targetmode=cogs
SUPFAM	SSF81340	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81340
TCDB	2.A.49.2	http://www.tcdb.org/search/result.php?tc=2.A.49.2
UCSC	uc003wcr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003wcr&org=rat
UniGene	Hs.121483	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.121483
UniProtKB	CLCN1_HUMAN	http://www.uniprot.org/uniprot/CLCN1_HUMAN
UniProtKB-AC	P35523	http://www.uniprot.org/uniprot/P35523
charge	swissprot:CLCN1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CLCN1_HUMAN
eggNOG	COG0038	http://eggnogapi.embl.de/nog_data/html/tree/COG0038
eggNOG	KOG0476	http://eggnogapi.embl.de/nog_data/html/tree/KOG0476
epestfind	swissprot:CLCN1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CLCN1_HUMAN
garnier	swissprot:CLCN1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CLCN1_HUMAN
helixturnhelix	swissprot:CLCN1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLCN1_HUMAN
hmoment	swissprot:CLCN1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CLCN1_HUMAN
iep	swissprot:CLCN1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CLCN1_HUMAN
inforesidue	swissprot:CLCN1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CLCN1_HUMAN
neXtProt	NX_P35523	http://www.nextprot.org/db/entry/NX_P35523
octanol	swissprot:CLCN1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CLCN1_HUMAN
pepcoil	swissprot:CLCN1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CLCN1_HUMAN
pepdigest	swissprot:CLCN1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CLCN1_HUMAN
pepinfo	swissprot:CLCN1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CLCN1_HUMAN
pepnet	swissprot:CLCN1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CLCN1_HUMAN
pepstats	swissprot:CLCN1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CLCN1_HUMAN
pepwheel	swissprot:CLCN1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CLCN1_HUMAN
pepwindow	swissprot:CLCN1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CLCN1_HUMAN
sigcleave	swissprot:CLCN1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CLCN1_HUMAN
## Database	ID	URL or Descriptions
# AltName	S6A14_HUMAN	Amino acid transporter ATB0+
# AltName	S6A14_HUMAN	Solute carrier family 6 member 14
# ChiTaRS	SLC6A14	human
# DISEASE	S6A14_HUMAN	Note=Genetic variations in SLC6A14 may be associated with obesity in some populations, as shown by significant differences in allele frequencies between obese and non-obese individuals. {ECO 0000269|PubMed 14660737, ECO 0000269|PubMed 14660752}. 
# DrugBank	DB00172	L-Proline
# DrugBank	DB00577	Valaciclovir
# DrugBank	DB01610	Valganciclovir
# Ensembl	ENST00000598581	ENSP00000470801; ENSG00000268104
# FUNCTION	S6A14_HUMAN	Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner. {ECO 0000269|PubMed 10446133}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_component	GO:0031526	brush border membrane; IEA:Ensembl.
# GO_component	GO:0031982	vesicle; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; TAS:Reactome.
# GO_function	S6A14_HUMAN	GO 0005328 neurotransmitter sodium symporter activity; IEA InterPro.
# GO_process	GO:0006520	cellular amino acid metabolic process; TAS:ProtInc.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006865	amino acid transport; TAS:Reactome.
# GO_process	GO:0009636	response to toxic substance; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006520	cellular amino acid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q9UN76	HS
# HGNC	HGNC:11047	SLC6A14
# InterPro	IPR000175	Na/ntran_symport
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Brite	ko04040	 Ion channels
# MIM	300444	gene
# MISCELLANEOUS	S6A14_HUMAN	Transport inhibited by BCH (2-aminobicyclo-[2.2.1]- heptane-2-carboxylic acid). 
# Organism	S6A14_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11616	PTHR11616; 2
# PRINTS	PR00176	NANEUSMPORT
# PROSITE	PS00610	NA_NEUROTRAN_SYMP_1
# PROSITE	PS00754	NA_NEUROTRAN_SYMP_2
# PROSITE	PS50267	NA_NEUROTRAN_SYMP_3
# Pfam	PF00209	SNF
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-352230	Amino acid transport across the plasma membrane
# Reactome	R-HSA-442660	Na+/Cl- dependent neurotransmitter transporters
# RecName	S6A14_HUMAN	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
# RefSeq	NP_009162	NM_007231.4
# SIMILARITY	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A14 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	S6A14_HUMAN	Membrane; Multi-pass membrane protein. 
# TCDB	2.A.22.2:the neurotransmitter	sodium symporter (nss) family
# TISSUE SPECIFICITY	Levels are highest in adult and fetal lung, in trachea and salivary gland. Lower levels detected in mammary gland, stomach and pituitary gland, and very low levels in colon, uterus, prostate and testis. {ECO:0000269|PubMed	10446133}. 
# UCSC	uc033eru	human
# eggNOG	COG0733	LUCA
# eggNOG	KOG3659	Eukaryota
BLAST	swissprot:S6A14_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S6A14_HUMAN
BioCyc	ZFISH:ENSG00000087916-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000087916-MONOMER
COXPRESdb	11254	http://coxpresdb.jp/data/gene/11254.shtml
CleanEx	HS_SLC6A14	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC6A14
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1074/jbc.274.34.23740	http://dx.doi.org/10.1074/jbc.274.34.23740
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1172/JCI200317491	http://dx.doi.org/10.1172/JCI200317491
DOI	10.1172/JCI200320448	http://dx.doi.org/10.1172/JCI200320448
DrugBank	DB00172	http://www.drugbank.ca/drugs/DB00172
DrugBank	DB00577	http://www.drugbank.ca/drugs/DB00577
DrugBank	DB01610	http://www.drugbank.ca/drugs/DB01610
EMBL	AF151978	http://www.ebi.ac.uk/ena/data/view/AF151978
EMBL	AL034411	http://www.ebi.ac.uk/ena/data/view/AL034411
EMBL	AL034411	http://www.ebi.ac.uk/ena/data/view/AL034411
EMBL	BC093710	http://www.ebi.ac.uk/ena/data/view/BC093710
EMBL	BC093712	http://www.ebi.ac.uk/ena/data/view/BC093712
EMBL	Z96810	http://www.ebi.ac.uk/ena/data/view/Z96810
EMBL	Z96810	http://www.ebi.ac.uk/ena/data/view/Z96810
Ensembl	ENST00000598581	http://www.ensembl.org/id/ENST00000598581
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0031526	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031526
GO_component	GO:0031982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031982
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005328
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_process	GO:0006520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GO_process	GO:0009636	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009636
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	SLC6A14	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC6A14
GeneID	11254	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11254
GeneTree	ENSGT00760000118857	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118857
HGNC	HGNC:11047	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11047
HOGENOM	HOG000116406	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116406&db=HOGENOM6
HOVERGEN	HBG071421	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG071421&db=HOVERGEN
HPA	HPA003193	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA003193
InParanoid	Q9UN76	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UN76
InterPro	IPR000175	http://www.ebi.ac.uk/interpro/entry/IPR000175
Jabion	11254	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=11254
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:11254	http://www.genome.jp/dbget-bin/www_bget?hsa:11254
KEGG_Orthology	KO:K05038	http://www.genome.jp/dbget-bin/www_bget?KO:K05038
MIM	300444	http://www.ncbi.nlm.nih.gov/omim/300444
OMA	FKCREKE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FKCREKE
OrthoDB	EOG091G08PX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08PX
PANTHER	PTHR11616	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11616
PRINTS	PR00176	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00176
PROSITE	PS00610	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00610
PROSITE	PS00754	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00754
PROSITE	PS50267	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50267
PSORT	swissprot:S6A14_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S6A14_HUMAN
PSORT-B	swissprot:S6A14_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S6A14_HUMAN
PSORT2	swissprot:S6A14_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S6A14_HUMAN
Pfam	PF00209	http://pfam.xfam.org/family/PF00209
PharmGKB	PA35910	http://www.pharmgkb.org/do/serve?objId=PA35910&objCls=Gene
Phobius	swissprot:S6A14_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S6A14_HUMAN
PhylomeDB	Q9UN76	http://phylomedb.org/?seqid=Q9UN76
ProteinModelPortal	Q9UN76	http://www.proteinmodelportal.org/query/uniprot/Q9UN76
PubMed	10446133	http://www.ncbi.nlm.nih.gov/pubmed/10446133
PubMed	14660737	http://www.ncbi.nlm.nih.gov/pubmed/14660737
PubMed	14660752	http://www.ncbi.nlm.nih.gov/pubmed/14660752
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
Reactome	R-HSA-352230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-352230
Reactome	R-HSA-442660	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442660
RefSeq	NP_009162	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_009162
STRING	9606.ENSP00000360967	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000360967&targetmode=cogs
TCDB	2.A.22.2	http://www.tcdb.org/search/result.php?tc=2.A.22.2
UCSC	uc033eru	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc033eru&org=rat
UniGene	Hs.522109	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.522109
UniProtKB	S6A14_HUMAN	http://www.uniprot.org/uniprot/S6A14_HUMAN
UniProtKB-AC	Q9UN76	http://www.uniprot.org/uniprot/Q9UN76
charge	swissprot:S6A14_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S6A14_HUMAN
eggNOG	COG0733	http://eggnogapi.embl.de/nog_data/html/tree/COG0733
eggNOG	KOG3659	http://eggnogapi.embl.de/nog_data/html/tree/KOG3659
epestfind	swissprot:S6A14_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S6A14_HUMAN
garnier	swissprot:S6A14_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S6A14_HUMAN
helixturnhelix	swissprot:S6A14_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S6A14_HUMAN
hmoment	swissprot:S6A14_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S6A14_HUMAN
iep	swissprot:S6A14_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S6A14_HUMAN
inforesidue	swissprot:S6A14_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S6A14_HUMAN
neXtProt	NX_Q9UN76	http://www.nextprot.org/db/entry/NX_Q9UN76
octanol	swissprot:S6A14_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S6A14_HUMAN
pepcoil	swissprot:S6A14_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S6A14_HUMAN
pepdigest	swissprot:S6A14_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S6A14_HUMAN
pepinfo	swissprot:S6A14_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S6A14_HUMAN
pepnet	swissprot:S6A14_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S6A14_HUMAN
pepstats	swissprot:S6A14_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S6A14_HUMAN
pepwheel	swissprot:S6A14_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S6A14_HUMAN
pepwindow	swissprot:S6A14_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S6A14_HUMAN
sigcleave	swissprot:S6A14_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S6A14_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ATPK_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=P56134-1; Sequence=Displayed; Name=2; IsoId=P56134-2; Sequence=VSP_000437; Note=No experimental confirmation available.; Name=3; IsoId=P56134-3; Sequence=VSP_046746; Note=No experimental confirmation available. Gene prediction based on EST data.; Name=4; IsoId=P56134-4; Sequence=VSP_000437, VSP_046746; Note=No experimental confirmation available. Gene prediction based on EST data.; 
# BioGrid	114923	39
# CCDS	CCDS34692	-. [P56134-3]
# CCDS	CCDS47653	-. [P56134-4]
# CCDS	CCDS47654	-. [P56134-2]
# CCDS	CCDS5665	-. [P56134-1]
# Ensembl	ENST00000292475	ENSP00000292475; ENSG00000241468. [P56134-1]
# Ensembl	ENST00000359832	ENSP00000352890; ENSG00000241468. [P56134-3]
# Ensembl	ENST00000394186	ENSP00000377740; ENSG00000241468. [P56134-2]
# Ensembl	ENST00000414062	ENSP00000412149; ENSG00000241468. [P56134-4]
# Ensembl	ENST00000488775	ENSP00000418197; ENSG00000241468. [P56134-4]
# ExpressionAtlas	P56134	baseline and differential
# FUNCTION	ATPK_HUMAN	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. 
# GO_component	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); IEA:Ensembl.
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0005753	mitochondrial proton-transporting ATP synthase complex; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0022857	transmembrane transporter activity; IC:UniProtKB.
# GO_process	GO:0006754	ATP biosynthetic process; TAS:Reactome.
# GO_process	GO:0015992	proton transport; NAS:UniProtKB.
# GO_process	GO:0042776	mitochondrial ATP synthesis coupled proton transport; IC:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P56134	HS
# HGNC	HGNC:848	ATP5J2
# IntAct	P56134	22
# InterPro	IPR019344	F1F0-ATPsyn_F_prd
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# Organism	ATPK_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR13080	PTHR13080
# Pfam	PF10206	WRW
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-163210	Formation of ATP by chemiosmotic coupling
# RecName	ATPK_HUMAN	ATP synthase subunit f, mitochondrial
# RefSeq	NP_001003713	NM_001003713.2. [P56134-2]
# RefSeq	NP_001003714	NM_001003714.2. [P56134-3]
# RefSeq	NP_001034267	NM_001039178.2. [P56134-4]
# RefSeq	NP_004880	NM_004889.3. [P56134-1]
# SIMILARITY	Belongs to the ATPase F chain family. {ECO	0000305}.
# SUBCELLULAR LOCATION	ATPK_HUMAN	Mitochondrion. Mitochondrion inner membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. 
# SUBUNIT	F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity). {ECO	0000250}. 
# TopDownProteomics	P56134-1	-. [P56134-1]
# TopDownProteomics	P56134-2	-. [P56134-2]
# UCSC	uc003uql	human. [P56134-1]
# eggNOG	ENOG4111PBN	LUCA
# eggNOG	KOG4092	Eukaryota
BLAST	swissprot:ATPK_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ATPK_HUMAN
BioCyc	ZFISH:HS08550-MONOMER	http://biocyc.org/getid?id=ZFISH:HS08550-MONOMER
COXPRESdb	9551	http://coxpresdb.jp/data/gene/9551.shtml
CleanEx	HS_ATP5J2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP5J2
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1073/pnas.95.14.8175	http://dx.doi.org/10.1073/pnas.95.14.8175
DOI	10.1074/mcp.M111.015131	http://dx.doi.org/10.1074/mcp.M111.015131
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1083423	http://dx.doi.org/10.1126/science.1083423
EMBL	AC073063	http://www.ebi.ac.uk/ena/data/view/AC073063
EMBL	AF047436	http://www.ebi.ac.uk/ena/data/view/AF047436
EMBL	AF088918	http://www.ebi.ac.uk/ena/data/view/AF088918
EMBL	AY046911	http://www.ebi.ac.uk/ena/data/view/AY046911
EMBL	BC003678	http://www.ebi.ac.uk/ena/data/view/BC003678
EMBL	CH236956	http://www.ebi.ac.uk/ena/data/view/CH236956
EMBL	CH471091	http://www.ebi.ac.uk/ena/data/view/CH471091
EMBL	CR456891	http://www.ebi.ac.uk/ena/data/view/CR456891
EMBL	CR542155	http://www.ebi.ac.uk/ena/data/view/CR542155
Ensembl	ENST00000292475	http://www.ensembl.org/id/ENST00000292475
Ensembl	ENST00000359832	http://www.ensembl.org/id/ENST00000359832
Ensembl	ENST00000394186	http://www.ensembl.org/id/ENST00000394186
Ensembl	ENST00000414062	http://www.ensembl.org/id/ENST00000414062
Ensembl	ENST00000488775	http://www.ensembl.org/id/ENST00000488775
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000276
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005753	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005753
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GO_process	GO:0006754	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006754
GO_process	GO:0015992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992
GO_process	GO:0042776	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042776
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ATP5J2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP5J2
GeneID	9551	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9551
GeneTree	ENSGT00510000046986	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00510000046986
HGNC	HGNC:848	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:848
HOGENOM	HOG000293164	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000293164&db=HOGENOM6
HOVERGEN	HBG002418	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG002418&db=HOVERGEN
HPA	HPA067267	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA067267
InParanoid	P56134	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P56134
IntAct	P56134	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P56134*
InterPro	IPR019344	http://www.ebi.ac.uk/interpro/entry/IPR019344
Jabion	9551	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9551
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:9551	http://www.genome.jp/dbget-bin/www_bget?hsa:9551
KEGG_Orthology	KO:K02130	http://www.genome.jp/dbget-bin/www_bget?KO:K02130
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
MINT	MINT-1370314	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1370314
PANTHER	PTHR13080	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13080
PSORT	swissprot:ATPK_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ATPK_HUMAN
PSORT-B	swissprot:ATPK_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ATPK_HUMAN
PSORT2	swissprot:ATPK_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ATPK_HUMAN
Pfam	PF10206	http://pfam.xfam.org/family/PF10206
PharmGKB	PA25138	http://www.pharmgkb.org/do/serve?objId=PA25138&objCls=Gene
Phobius	swissprot:ATPK_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ATPK_HUMAN
PhylomeDB	P56134	http://phylomedb.org/?seqid=P56134
ProteinModelPortal	P56134	http://www.proteinmodelportal.org/query/uniprot/P56134
PubMed	12690205	http://www.ncbi.nlm.nih.gov/pubmed/12690205
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	22223895	http://www.ncbi.nlm.nih.gov/pubmed/22223895
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	9653160	http://www.ncbi.nlm.nih.gov/pubmed/9653160
Reactome	R-HSA-163210	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-163210
RefSeq	NP_001003713	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001003713
RefSeq	NP_001003714	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001003714
RefSeq	NP_001034267	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001034267
RefSeq	NP_004880	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004880
STRING	9606.ENSP00000292475	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000292475&targetmode=cogs
UCSC	uc003uql	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003uql&org=rat
UniGene	Hs.521056	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.521056
UniGene	Hs.656515	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.656515
UniProtKB	ATPK_HUMAN	http://www.uniprot.org/uniprot/ATPK_HUMAN
UniProtKB-AC	P56134	http://www.uniprot.org/uniprot/P56134
charge	swissprot:ATPK_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ATPK_HUMAN
eggNOG	ENOG4111PBN	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111PBN
eggNOG	KOG4092	http://eggnogapi.embl.de/nog_data/html/tree/KOG4092
epestfind	swissprot:ATPK_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ATPK_HUMAN
garnier	swissprot:ATPK_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ATPK_HUMAN
helixturnhelix	swissprot:ATPK_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATPK_HUMAN
hmoment	swissprot:ATPK_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ATPK_HUMAN
iep	swissprot:ATPK_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ATPK_HUMAN
inforesidue	swissprot:ATPK_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ATPK_HUMAN
neXtProt	NX_P56134	http://www.nextprot.org/db/entry/NX_P56134
octanol	swissprot:ATPK_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ATPK_HUMAN
pepcoil	swissprot:ATPK_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ATPK_HUMAN
pepdigest	swissprot:ATPK_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ATPK_HUMAN
pepinfo	swissprot:ATPK_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ATPK_HUMAN
pepnet	swissprot:ATPK_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ATPK_HUMAN
pepstats	swissprot:ATPK_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ATPK_HUMAN
pepwheel	swissprot:ATPK_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ATPK_HUMAN
pepwindow	swissprot:ATPK_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ATPK_HUMAN
sigcleave	swissprot:ATPK_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ATPK_HUMAN
## Database	ID	URL or Descriptions
# AltName	NTCP5_HUMAN	Na(+)/bile acid cotransporter 5
# AltName	NTCP5_HUMAN	Solute carrier family 10 member 5
# Ensembl	ENST00000518568	ENSP00000428612; ENSG00000253598
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	NTCP5_HUMAN	GO 0008508 bile acid sodium symporter activity; IBA GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# HGNC	HGNC:22981	SLC10A5
# InterPro	IPR002657:BilAc	Na_symport/Acr3
# InterPro	IPR030209	SLC10A5
# KEGG_Brite	ko02001	Solute carrier family
# Organism	NTCP5_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10361	PTHR10361
# PANTHER	PTHR10361:SF29	PTHR10361:SF29
# Pfam	PF01758	SBF
# Proteomes	UP000005640	Chromosome 8
# RecName	NTCP5_HUMAN	Sodium/bile acid cotransporter 5
# RefSeq	NP_001010893	NM_001010893.2
# SIMILARITY	Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	NTCP5_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	2.A.28.1:the bile acid	na(+) symporter (bass) family
# UCSC	uc011lfs	human
# eggNOG	COG0385	LUCA
# eggNOG	KOG2718	Eukaryota
BLAST	swissprot:NTCP5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NTCP5_HUMAN
BioCyc	ZFISH:G66-33022-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33022-MONOMER
COXPRESdb	347051	http://coxpresdb.jp/data/gene/347051.shtml
CleanEx	HS_SLC10A5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC10A5
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AK095808	http://www.ebi.ac.uk/ena/data/view/AK095808
EMBL	AY825924	http://www.ebi.ac.uk/ena/data/view/AY825924
EMBL	BC136625	http://www.ebi.ac.uk/ena/data/view/BC136625
EMBL	BC136631	http://www.ebi.ac.uk/ena/data/view/BC136631
Ensembl	ENST00000518568	http://www.ensembl.org/id/ENST00000518568
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0008508	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008508
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GeneCards	SLC10A5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC10A5
GeneID	347051	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=347051
GeneTree	ENSGT00550000074505	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074505
HGNC	HGNC:22981	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:22981
HOGENOM	HOG000037944	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000037944&db=HOGENOM6
HOVERGEN	HBG002872	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG002872&db=HOVERGEN
HPA	HPA025966	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA025966
InParanoid	Q5PT55	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q5PT55
InterPro	IPR002657	http://www.ebi.ac.uk/interpro/entry/IPR002657
InterPro	IPR030209	http://www.ebi.ac.uk/interpro/entry/IPR030209
Jabion	347051	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=347051
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:347051	http://www.genome.jp/dbget-bin/www_bget?hsa:347051
KEGG_Orthology	KO:K14343	http://www.genome.jp/dbget-bin/www_bget?KO:K14343
OMA	CAFGCKI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CAFGCKI
OrthoDB	EOG091G0HEJ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0HEJ
PANTHER	PTHR10361	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10361
PANTHER	PTHR10361:SF29	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10361:SF29
PSORT	swissprot:NTCP5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NTCP5_HUMAN
PSORT-B	swissprot:NTCP5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NTCP5_HUMAN
PSORT2	swissprot:NTCP5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NTCP5_HUMAN
Pfam	PF01758	http://pfam.xfam.org/family/PF01758
PharmGKB	PA134933839	http://www.pharmgkb.org/do/serve?objId=PA134933839&objCls=Gene
Phobius	swissprot:NTCP5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NTCP5_HUMAN
PhylomeDB	Q5PT55	http://phylomedb.org/?seqid=Q5PT55
ProteinModelPortal	Q5PT55	http://www.proteinmodelportal.org/query/uniprot/Q5PT55
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
RefSeq	NP_001010893	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001010893
STRING	9606.ENSP00000428612	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000428612&targetmode=cogs
TCDB	2.A.28.1	http://www.tcdb.org/search/result.php?tc=2.A.28.1
UCSC	uc011lfs	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc011lfs&org=rat
UniGene	Hs.683849	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.683849
UniProtKB	NTCP5_HUMAN	http://www.uniprot.org/uniprot/NTCP5_HUMAN
UniProtKB-AC	Q5PT55	http://www.uniprot.org/uniprot/Q5PT55
charge	swissprot:NTCP5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NTCP5_HUMAN
eggNOG	COG0385	http://eggnogapi.embl.de/nog_data/html/tree/COG0385
eggNOG	KOG2718	http://eggnogapi.embl.de/nog_data/html/tree/KOG2718
epestfind	swissprot:NTCP5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NTCP5_HUMAN
garnier	swissprot:NTCP5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NTCP5_HUMAN
helixturnhelix	swissprot:NTCP5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NTCP5_HUMAN
hmoment	swissprot:NTCP5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NTCP5_HUMAN
iep	swissprot:NTCP5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NTCP5_HUMAN
inforesidue	swissprot:NTCP5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NTCP5_HUMAN
neXtProt	NX_Q5PT55	http://www.nextprot.org/db/entry/NX_Q5PT55
octanol	swissprot:NTCP5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NTCP5_HUMAN
pepcoil	swissprot:NTCP5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NTCP5_HUMAN
pepdigest	swissprot:NTCP5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NTCP5_HUMAN
pepinfo	swissprot:NTCP5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NTCP5_HUMAN
pepnet	swissprot:NTCP5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NTCP5_HUMAN
pepstats	swissprot:NTCP5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NTCP5_HUMAN
pepwheel	swissprot:NTCP5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NTCP5_HUMAN
pepwindow	swissprot:NTCP5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NTCP5_HUMAN
sigcleave	swissprot:NTCP5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NTCP5_HUMAN
## Database	ID	URL or Descriptions
# AltName	CX6A2_HUMAN	Cytochrome c oxidase polypeptide VIa-heart
# AltName	CX6A2_HUMAN	Cytochrome c oxidase subunit VIA-muscle
# BioGrid	107732	5
# CDD	cd00925	Cyt_c_Oxidase_VIa
# ChiTaRS	COX6A2	human
# DrugBank	DB02659	Cholic Acid
# Ensembl	ENST00000287490	ENSP00000287490; ENSG00000156885
# FUNCTION	CX6A2_HUMAN	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. 
# GO_component	GO:0005751	mitochondrial respiratory chain complex IV; IBA:GO_Central.
# GO_function	GO:0004129	cytochrome-c oxidase activity; IEA:InterPro.
# GO_function	GO:0030234	enzyme regulator activity; IBA:GO_Central.
# GO_process	GO:0006091	generation of precursor metabolites and energy; TAS:ProtInc.
# GO_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen; IBA:GO_Central.
# GO_process	GO:0009060	aerobic respiration; IBA:GO_Central.
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0030234	enzyme regulator activity
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# Gene3D	4.10.95.10	-; 1.
# Genevisible	Q02221	HS
# HGNC	HGNC:2279	COX6A2
# IntAct	Q02221	10
# InterPro	IPR001349	Cyt_c_oxidase_su6a
# InterPro	IPR018507	Cyt_c_oxidase_su6a_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	602009	gene
# Organism	CX6A2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11504	PTHR11504
# PIR	JC1304	OGHU6A
# PIRSF	PIRSF000277	COX6A1
# PROSITE	PS01329	COX6A
# Pfam	PF02046	COX6A
# ProDom	PD006036	Cyt_c_oxidase_su6a
# Proteomes	UP000005640	Chromosome 16
# RecName	CX6A2_HUMAN	Cytochrome c oxidase subunit 6A2, mitochondrial
# RefSeq	NP_005196	NM_005205.3
# SIMILARITY	Belongs to the cytochrome c oxidase subunit 6A family. {ECO	0000305}.
# SUBCELLULAR LOCATION	CX6A2_HUMAN	Mitochondrion inner membrane. 
# SUPFAM	SSF81411	SSF81411
# TCDB	3.D.4.11	the proton-translocating cytochrome oxidase (cox) superfamily
# TISSUE SPECIFICITY	Expressed specifically in heart and muscle. {ECO:0000269|PubMed	1327966}. 
# UCSC	uc002ebx	human
# eggNOG	ENOG411253X	LUCA
# eggNOG	KOG3469	Eukaryota
BLAST	swissprot:CX6A2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CX6A2_HUMAN
BioCyc	ZFISH:HS08157-MONOMER	http://biocyc.org/getid?id=ZFISH:HS08157-MONOMER
COXPRESdb	1339	http://coxpresdb.jp/data/gene/1339.shtml
CleanEx	HS_COX6A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_COX6A2
DOI	10.1006/geno.1997.4687	http://dx.doi.org/10.1006/geno.1997.4687
DOI	10.1016/0378-1119(92)90288-Z	http://dx.doi.org/10.1016/0378-1119(92)90288-Z
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB02659	http://www.drugbank.ca/drugs/DB02659
EMBL	BC029818	http://www.ebi.ac.uk/ena/data/view/BC029818
EMBL	M83308	http://www.ebi.ac.uk/ena/data/view/M83308
EMBL	U66875	http://www.ebi.ac.uk/ena/data/view/U66875
Ensembl	ENST00000287490	http://www.ensembl.org/id/ENST00000287490
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005751	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005751
GO_function	GO:0004129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004129
GO_function	GO:0030234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234
GO_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GO_process	GO:0006123	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006123
GO_process	GO:0009060	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009060
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0030234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
Gene3D	4.10.95.10	http://www.cathdb.info/version/latest/superfamily/4.10.95.10
GeneCards	COX6A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=COX6A2
GeneID	1339	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1339
GeneTree	ENSGT00390000002756	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002756
HGNC	HGNC:2279	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2279
HOGENOM	HOG000193965	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000193965&db=HOGENOM6
HOVERGEN	HBG060482	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG060482&db=HOVERGEN
InParanoid	Q02221	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q02221
IntAct	Q02221	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q02221*
InterPro	IPR001349	http://www.ebi.ac.uk/interpro/entry/IPR001349
InterPro	IPR018507	http://www.ebi.ac.uk/interpro/entry/IPR018507
Jabion	1339	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1339
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Gene	hsa:1339	http://www.genome.jp/dbget-bin/www_bget?hsa:1339
KEGG_Orthology	KO:K02266	http://www.genome.jp/dbget-bin/www_bget?KO:K02266
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	602009	http://www.ncbi.nlm.nih.gov/omim/602009
OMA	NSWLHAG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NSWLHAG
OrthoDB	EOG091G0C5F	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0C5F
PANTHER	PTHR11504	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11504
PROSITE	PS01329	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01329
PSORT	swissprot:CX6A2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CX6A2_HUMAN
PSORT-B	swissprot:CX6A2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CX6A2_HUMAN
PSORT2	swissprot:CX6A2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CX6A2_HUMAN
Pfam	PF02046	http://pfam.xfam.org/family/PF02046
PharmGKB	PA26796	http://www.pharmgkb.org/do/serve?objId=PA26796&objCls=Gene
Phobius	swissprot:CX6A2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CX6A2_HUMAN
PhylomeDB	Q02221	http://phylomedb.org/?seqid=Q02221
ProteinModelPortal	Q02221	http://www.proteinmodelportal.org/query/uniprot/Q02221
PubMed	1327966	http://www.ncbi.nlm.nih.gov/pubmed/1327966
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	9177785	http://www.ncbi.nlm.nih.gov/pubmed/9177785
RefSeq	NP_005196	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005196
SMR	Q02221	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q02221
STRING	9606.ENSP00000287490	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000287490&targetmode=cogs
SUPFAM	SSF81411	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81411
TCDB	3.D.4.11	http://www.tcdb.org/search/result.php?tc=3.D.4.11
UCSC	uc002ebx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ebx&org=rat
UniGene	Hs.250760	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.250760
UniProtKB	CX6A2_HUMAN	http://www.uniprot.org/uniprot/CX6A2_HUMAN
UniProtKB-AC	Q02221	http://www.uniprot.org/uniprot/Q02221
charge	swissprot:CX6A2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CX6A2_HUMAN
eggNOG	ENOG411253X	http://eggnogapi.embl.de/nog_data/html/tree/ENOG411253X
eggNOG	KOG3469	http://eggnogapi.embl.de/nog_data/html/tree/KOG3469
epestfind	swissprot:CX6A2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CX6A2_HUMAN
garnier	swissprot:CX6A2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CX6A2_HUMAN
helixturnhelix	swissprot:CX6A2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CX6A2_HUMAN
hmoment	swissprot:CX6A2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CX6A2_HUMAN
iep	swissprot:CX6A2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CX6A2_HUMAN
inforesidue	swissprot:CX6A2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CX6A2_HUMAN
neXtProt	NX_Q02221	http://www.nextprot.org/db/entry/NX_Q02221
octanol	swissprot:CX6A2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CX6A2_HUMAN
pepcoil	swissprot:CX6A2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CX6A2_HUMAN
pepdigest	swissprot:CX6A2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CX6A2_HUMAN
pepinfo	swissprot:CX6A2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CX6A2_HUMAN
pepnet	swissprot:CX6A2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CX6A2_HUMAN
pepstats	swissprot:CX6A2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CX6A2_HUMAN
pepwheel	swissprot:CX6A2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CX6A2_HUMAN
pepwindow	swissprot:CX6A2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CX6A2_HUMAN
sigcleave	swissprot:CX6A2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CX6A2_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	129036	4
# ChiTaRS	SLC41A1	human
# Ensembl	ENST00000367137	ENSP00000356105; ENSG00000133065
# ExpressionAtlas	Q8IVJ1	baseline and differential
# FUNCTION	S41A1_HUMAN	Acts as a magnesium transporter that is responsive to magnesium balance. {ECO 0000269|PubMed 15713785}. 
# GO_component	GO:0005623	cell; IMP:ParkinsonsUK-UCL.
# GO_component	GO:0005886	plasma membrane; IDA:ParkinsonsUK-UCL.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0016323	basolateral plasma membrane; IDA:ParkinsonsUK-UCL.
# GO_component	GO:0043234	protein complex; IDA:ParkinsonsUK-UCL.
# GO_function	GO:0015095	magnesium ion transmembrane transporter activity; IDA:ParkinsonsUK-UCL.
# GO_function	GO:0022892	substrate-specific transporter activity; IDA:ParkinsonsUK-UCL.
# GO_function	GO:0072509	divalent inorganic cation transmembrane transporter activity; ISS:ParkinsonsUK-UCL.
# GO_function	S41A1_HUMAN	GO 0061768 magnesium sodium antiporter activity; IMP ParkinsonsUK-UCL.
# GO_process	GO:0010961	cellular magnesium ion homeostasis; IMP:ParkinsonsUK-UCL.
# GO_process	GO:0015693	magnesium ion transport; IDA:ParkinsonsUK-UCL.
# GO_process	GO:0055085	transmembrane transport; IBA:GO_Central.
# GO_process	GO:0070838	divalent metal ion transport; ISS:ParkinsonsUK-UCL.
# GO_process	GO:0071286	cellular response to magnesium ion; ISS:ParkinsonsUK-UCL.
# GO_process	GO:1903830	magnesium ion transmembrane transport; IDA:ParkinsonsUK-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005623	cell
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.10.357.20	-; 2.
# Genevisible	Q8IVJ1	HS
# HGNC	HGNC:19429	SLC41A1
# InterPro	IPR006667	SLC41_membr_dom
# KEGG_Brite	ko02001	Solute carrier family
# MIM	610801	gene
# Organism	S41A1_HUMAN	Homo sapiens (Human)
# Pfam	PF01769	MgtE; 2
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-425410	Metal ion SLC transporters
# RecName	S41A1_HUMAN	Solute carrier family 41 member 1
# RefSeq	NP_776253	NM_173854.5
# RefSeq	XP_005245126	XM_005245069.2
# SIMILARITY	Belongs to the SLC41A transporter family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S41A1_HUMAN	Cell membrane; Multi-pass membrane protein. 
# TCDB	1.A.26.2	the mg(2+) transporter-e (mgte) family
# TISSUE SPECIFICITY	Highest expression levels in heart and testis, slightly less in skeletal muscles, prostate, adrenal gland and thyroid, and weakest in the hematopoietic tissues bones marrow, lymph node, thymus and spleen. {ECO:0000269|PubMed	12810078}. 
# UCSC	uc001hdh	human
# eggNOG	ENOG410XSTG	LUCA
# eggNOG	KOG3788	Eukaryota
BLAST	swissprot:S41A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S41A1_HUMAN
COXPRESdb	254428	http://coxpresdb.jp/data/gene/254428.shtml
CleanEx	HS_SLC41A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC41A1
DOI	10.1016/S0006-291X(03)01030-1	http://dx.doi.org/10.1016/S0006-291X(03)01030-1
DOI	10.1152/physiolgenomics.00261.2004	http://dx.doi.org/10.1152/physiolgenomics.00261.2004
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AJ514402	http://www.ebi.ac.uk/ena/data/view/AJ514402
EMBL	AL831974	http://www.ebi.ac.uk/ena/data/view/AL831974
EMBL	AL832001	http://www.ebi.ac.uk/ena/data/view/AL832001
EMBL	AL832362	http://www.ebi.ac.uk/ena/data/view/AL832362
EMBL	BX641054	http://www.ebi.ac.uk/ena/data/view/BX641054
EMBL	BX648979	http://www.ebi.ac.uk/ena/data/view/BX648979
Ensembl	ENST00000367137	http://www.ensembl.org/id/ENST00000367137
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005623	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005623
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GO_function	GO:0015095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015095
GO_function	GO:0022892	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022892
GO_function	GO:0061768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061768
GO_function	GO:0072509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072509
GO_process	GO:0010961	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010961
GO_process	GO:0015693	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015693
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GO_process	GO:0070838	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070838
GO_process	GO:0071286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071286
GO_process	GO:1903830	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903830
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005623	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005623
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.10.357.20	http://www.cathdb.info/version/latest/superfamily/1.10.357.20
GeneCards	SLC41A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC41A1
GeneID	254428	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=254428
GeneTree	ENSGT00390000016816	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000016816
H-InvDB	HIX0001523	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0001523
HGNC	HGNC:19429	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:19429
HOGENOM	HOG000007017	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007017&db=HOGENOM6
HOVERGEN	HBG057187	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG057187&db=HOVERGEN
HPA	HPA015138	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA015138
InParanoid	Q8IVJ1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8IVJ1
IntAct	Q8IVJ1	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8IVJ1*
InterPro	IPR006667	http://www.ebi.ac.uk/interpro/entry/IPR006667
Jabion	254428	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=254428
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:254428	http://www.genome.jp/dbget-bin/www_bget?hsa:254428
KEGG_Orthology	KO:K15122	http://www.genome.jp/dbget-bin/www_bget?KO:K15122
MIM	610801	http://www.ncbi.nlm.nih.gov/omim/610801
OMA	DDWQYIY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DDWQYIY
OrthoDB	EOG091G08MB	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08MB
PSORT	swissprot:S41A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S41A1_HUMAN
PSORT-B	swissprot:S41A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S41A1_HUMAN
PSORT2	swissprot:S41A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S41A1_HUMAN
Pfam	PF01769	http://pfam.xfam.org/family/PF01769
PharmGKB	PA134889327	http://www.pharmgkb.org/do/serve?objId=PA134889327&objCls=Gene
Phobius	swissprot:S41A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S41A1_HUMAN
PhylomeDB	Q8IVJ1	http://phylomedb.org/?seqid=Q8IVJ1
ProteinModelPortal	Q8IVJ1	http://www.proteinmodelportal.org/query/uniprot/Q8IVJ1
PubMed	12810078	http://www.ncbi.nlm.nih.gov/pubmed/12810078
PubMed	15713785	http://www.ncbi.nlm.nih.gov/pubmed/15713785
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
Reactome	R-HSA-425410	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425410
RefSeq	NP_776253	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_776253
RefSeq	XP_005245126	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005245126
STRING	9606.ENSP00000356105	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000356105&targetmode=cogs
TCDB	1.A.26.2	http://www.tcdb.org/search/result.php?tc=1.A.26.2
UCSC	uc001hdh	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001hdh&org=rat
UniGene	Hs.20274	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.20274
UniProtKB	S41A1_HUMAN	http://www.uniprot.org/uniprot/S41A1_HUMAN
UniProtKB-AC	Q8IVJ1	http://www.uniprot.org/uniprot/Q8IVJ1
charge	swissprot:S41A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S41A1_HUMAN
eggNOG	ENOG410XSTG	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSTG
eggNOG	KOG3788	http://eggnogapi.embl.de/nog_data/html/tree/KOG3788
epestfind	swissprot:S41A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S41A1_HUMAN
garnier	swissprot:S41A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S41A1_HUMAN
helixturnhelix	swissprot:S41A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S41A1_HUMAN
hmoment	swissprot:S41A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S41A1_HUMAN
iep	swissprot:S41A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S41A1_HUMAN
inforesidue	swissprot:S41A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S41A1_HUMAN
neXtProt	NX_Q8IVJ1	http://www.nextprot.org/db/entry/NX_Q8IVJ1
octanol	swissprot:S41A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S41A1_HUMAN
pepcoil	swissprot:S41A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S41A1_HUMAN
pepdigest	swissprot:S41A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S41A1_HUMAN
pepinfo	swissprot:S41A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S41A1_HUMAN
pepnet	swissprot:S41A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S41A1_HUMAN
pepstats	swissprot:S41A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S41A1_HUMAN
pepwheel	swissprot:S41A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S41A1_HUMAN
pepwindow	swissprot:S41A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S41A1_HUMAN
sigcleave	swissprot:S41A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S41A1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CC055_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=A1A4F0-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=A1A4F0-2; Sequence=VSP_036612; Note=No experimental confirmation available.; Name=3; IsoId=A1A4F0-3; Sequence=VSP_045571; Note=No experimental confirmation available.; Name=4; IsoId=A1A4F0-4; Sequence=VSP_046204; Note=No experimental confirmation available.; 
# AltName	PQ-loop repeat-containing protein 2-like {ECO:0000312|HGNC	HGNC:25146}
# CCDS	CCDS46942	-. [A1A4F0-4]
# CCDS	CCDS46943	-. [A1A4F0-1]
# CCDS	CCDS46944	-. [A1A4F0-2]
# CCDS	CCDS58859	-. [A1A4F0-3]
# ChiTaRS	C3orf55	human
# Ensembl	ENST00000312275	ENSP00000312323; ENSG00000174899. [A1A4F0-2]
# Ensembl	ENST00000426338	ENSP00000387918; ENSG00000174899. [A1A4F0-4]
# Ensembl	ENST00000449199	ENSP00000413228; ENSG00000174899. [A1A4F0-1]
# Ensembl	ENST00000459838	ENSP00000420317; ENSG00000174899. [A1A4F0-3]
# ExpressionAtlas	A1A4F0	baseline and differential
# GO_component	GO:0005765	lysosomal membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IBA:GO_Central.
# GO_function	GO:0015181	arginine transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015189	L-lysine transmembrane transporter activity; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# Genevisible	A1A4F0	HS
# HGNC	HGNC:25146	PQLC2L
# Organism	CC055_HUMAN	Homo sapiens (Human)
# Proteomes	UP000005640	Chromosome 3
# RecName	Putative uncharacterized protein PQLC2L {ECO	0000305}
# RefSeq	NP_001093247	NM_001099777.3. [A1A4F0-2]
# RefSeq	NP_001123473	NM_001130001.2. [A1A4F0-4]
# RefSeq	NP_001123474	NM_001130002.2. [A1A4F0-1]
# RefSeq	NP_001230658	NM_001243729.1. [A1A4F0-3]
# SEQUENCE CAUTION	Sequence=AAH29129.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO	0000305};
# UCSC	uc003fbo	human. [A1A4F0-1]
# eggNOG	ENOG4111FM2	LUCA
# eggNOG	KOG2913	Eukaryota
BLAST	swissprot:CC055_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CC055_HUMAN
COXPRESdb	152078	http://coxpresdb.jp/data/gene/152078.shtml
CleanEx	HS_C3orf55	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_C3orf55
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC084212	http://www.ebi.ac.uk/ena/data/view/AC084212
EMBL	BC010062	http://www.ebi.ac.uk/ena/data/view/BC010062
EMBL	BC029129	http://www.ebi.ac.uk/ena/data/view/BC029129
EMBL	BC126187	http://www.ebi.ac.uk/ena/data/view/BC126187
EMBL	BC126189	http://www.ebi.ac.uk/ena/data/view/BC126189
EMBL	BC144066	http://www.ebi.ac.uk/ena/data/view/BC144066
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
Ensembl	ENST00000312275	http://www.ensembl.org/id/ENST00000312275
Ensembl	ENST00000426338	http://www.ensembl.org/id/ENST00000426338
Ensembl	ENST00000449199	http://www.ensembl.org/id/ENST00000449199
Ensembl	ENST00000459838	http://www.ensembl.org/id/ENST00000459838
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015181	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015181
GO_function	GO:0015189	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015189
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GeneCards	PQLC2L	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=PQLC2L
GeneID	152078	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=152078
GeneTree	ENSGT00390000003344	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000003344
HGNC	HGNC:25146	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:25146
HOGENOM	HOG000111368	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000111368&db=HOGENOM6
HPA	HPA054395	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA054395
InParanoid	A1A4F0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=A1A4F0
IntAct	A1A4F0	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=A1A4F0*
Jabion	152078	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=152078
KEGG_Gene	hsa:152078	http://www.genome.jp/dbget-bin/www_bget?hsa:152078
OMA	REHLTCL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=REHLTCL
OrthoDB	EOG091G0SAK	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0SAK
PSORT	swissprot:CC055_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CC055_HUMAN
PSORT-B	swissprot:CC055_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CC055_HUMAN
PSORT2	swissprot:CC055_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CC055_HUMAN
PharmGKB	PA143485331	http://www.pharmgkb.org/do/serve?objId=PA143485331&objCls=Gene
Phobius	swissprot:CC055_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CC055_HUMAN
PhylomeDB	A1A4F0	http://phylomedb.org/?seqid=A1A4F0
ProteinModelPortal	A1A4F0	http://www.proteinmodelportal.org/query/uniprot/A1A4F0
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
RefSeq	NP_001093247	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001093247
RefSeq	NP_001123473	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001123473
RefSeq	NP_001123474	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001123474
RefSeq	NP_001230658	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001230658
STRING	9606.ENSP00000413228	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000413228&targetmode=cogs
UCSC	uc003fbo	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003fbo&org=rat
UniGene	Hs.259046	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.259046
UniProtKB	CC055_HUMAN	http://www.uniprot.org/uniprot/CC055_HUMAN
UniProtKB-AC	A1A4F0	http://www.uniprot.org/uniprot/A1A4F0
charge	swissprot:CC055_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CC055_HUMAN
eggNOG	ENOG4111FM2	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111FM2
eggNOG	KOG2913	http://eggnogapi.embl.de/nog_data/html/tree/KOG2913
epestfind	swissprot:CC055_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CC055_HUMAN
garnier	swissprot:CC055_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CC055_HUMAN
helixturnhelix	swissprot:CC055_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CC055_HUMAN
hmoment	swissprot:CC055_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CC055_HUMAN
iep	swissprot:CC055_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CC055_HUMAN
inforesidue	swissprot:CC055_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CC055_HUMAN
neXtProt	NX_A1A4F0	http://www.nextprot.org/db/entry/NX_A1A4F0
octanol	swissprot:CC055_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CC055_HUMAN
pepcoil	swissprot:CC055_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CC055_HUMAN
pepdigest	swissprot:CC055_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CC055_HUMAN
pepinfo	swissprot:CC055_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CC055_HUMAN
pepnet	swissprot:CC055_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CC055_HUMAN
pepstats	swissprot:CC055_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CC055_HUMAN
pepwheel	swissprot:CC055_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CC055_HUMAN
pepwindow	swissprot:CC055_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CC055_HUMAN
sigcleave	swissprot:CC055_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CC055_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNU1_HUMAN	Calcium-activated potassium channel subunit alpha-3
# AltName	KCNU1_HUMAN	Calcium-activated potassium channel, subfamily M subunit alpha-3
# AltName	KCNU1_HUMAN	KCa5
# AltName	KCNU1_HUMAN	Slowpoke homolog 3
# DOMAIN	KCNU1_HUMAN	The C-terminal cytosolic region confers the pH-dependence. {ECO 0000250}. 
# DOMAIN	KCNU1_HUMAN	The RCK N-terminal domain mediates the homotetramerization, thereby promoting the assembly of monomers into functional potassium channel. {ECO 0000250}. 
# DOMAIN	KCNU1_HUMAN	The S4 segment, which is characterized by a series of positively charged amino acids at every third position, is part of the voltage-sensor. {ECO 0000250}. 
# DOMAIN	KCNU1_HUMAN	The pore-forming domain (also referred as P region) is imbedded into the membrane, and forms the selectivity filter of the pore. It contains the signature sequence of potassium channels that displays selectivity to potassium (By similarity). {ECO 0000250}. 
# Ensembl	ENST00000399881	ENSP00000382770; ENSG00000215262
# ExpressionAtlas	A8MYU2	baseline and differential
# FUNCTION	KCNU1_HUMAN	Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina. {ECO 0000269|PubMed 23129643}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IBA:GO_Central.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IBA:GO_Central.
# GO_function	GO:0005267	potassium channel activity; TAS:Reactome.
# GO_function	GO:0060072	large conductance calcium-activated potassium channel activity; IBA:GO_Central.
# GO_process	GO:0035036	sperm-egg recognition; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# Gene3D	3.40.50.720	-; 2.
# Genevisible	A8MYU2	HS
# HGNC	HGNC:18867	KCNU1
# InterPro	IPR003929	K_chnl_Ca-activ_BK_asu
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR016040	NAD(P)-bd_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04270	Vascular smooth muscle contraction
# MIM	615215	gene
# Organism	KCNU1_HUMAN	Homo sapiens (Human)
# PDB	4HPF	X-ray; 3.40 A; A/B=330-1062
# PRINTS	PR01449	BKCHANNELA
# Pfam	PF00520	Ion_trans
# Pfam	PF03493	BK_channel_a
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-1300642	Sperm Motility And Taxes
# RecName	KCNU1_HUMAN	Potassium channel subfamily U member 1
# RefSeq	NP_001027006	NM_001031836.2
# SIMILARITY	Belongs to the potassium channel family. Calcium- activated (TC 1.A.1.3) subfamily. KCa5.1/KCNU1 sub-subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 RCK N-terminal domain. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCNU1_HUMAN	Cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUBUNIT	Homotetramer; which constitutes the calcium-activated potassium channel. May interact with LRRC52; this interaction may change channel gating properties, such as shifting gating to more negative potentials at a given pH. {ECO	0000250}. 
# TISSUE SPECIFICITY	Testis-specific. {ECO:0000269|PubMed	9452476}. 
# UCSC	uc010lvw	human
# eggNOG	ENOG410YUX1	LUCA
# eggNOG	KOG1420	Eukaryota
BLAST	swissprot:KCNU1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNU1_HUMAN
BioCyc	ZFISH:G66-33782-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33782-MONOMER
COXPRESdb	157855	http://coxpresdb.jp/data/gene/157855.shtml
CleanEx	HS_KCNU1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNU1
DIP	DIP-60091N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-60091N
DOI	10.1038/nature04406	http://dx.doi.org/10.1038/nature04406
DOI	10.1073/pnas.1215078109	http://dx.doi.org/10.1073/pnas.1215078109
DOI	10.1074/jbc.273.6.3509	http://dx.doi.org/10.1074/jbc.273.6.3509
EMBL	AC124076	http://www.ebi.ac.uk/ena/data/view/AC124076
Ensembl	ENST00000399881	http://www.ensembl.org/id/ENST00000399881
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_function	GO:0060072	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060072
GO_process	GO:0035036	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035036
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	3.40.50.720	http://www.cathdb.info/version/latest/superfamily/3.40.50.720
GeneCards	KCNU1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNU1
GeneID	157855	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=157855
GeneTree	ENSGT00530000063026	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063026
H-InvDB	HIX0020845	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0020845
HGNC	HGNC:18867	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18867
HOGENOM	HOG000019856	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000019856&db=HOGENOM6
HOVERGEN	HBG052222	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052222&db=HOVERGEN
InParanoid	A8MYU2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=A8MYU2
InterPro	IPR003929	http://www.ebi.ac.uk/interpro/entry/IPR003929
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR016040	http://www.ebi.ac.uk/interpro/entry/IPR016040
Jabion	157855	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=157855
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:157855	http://www.genome.jp/dbget-bin/www_bget?hsa:157855
KEGG_Orthology	KO:K05274	http://www.genome.jp/dbget-bin/www_bget?KO:K05274
KEGG_Pathway	ko04270	http://www.genome.jp/kegg-bin/show_pathway?ko04270
MIM	615215	http://www.ncbi.nlm.nih.gov/omim/615215
OMA	DSSGMFH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DSSGMFH
OrthoDB	EOG091G148D	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G148D
PDB	4HPF	http://www.ebi.ac.uk/pdbe-srv/view/entry/4HPF
PDBsum	4HPF	http://www.ebi.ac.uk/pdbsum/4HPF
PRINTS	PR01449	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01449
PSORT	swissprot:KCNU1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNU1_HUMAN
PSORT-B	swissprot:KCNU1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNU1_HUMAN
PSORT2	swissprot:KCNU1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNU1_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF03493	http://pfam.xfam.org/family/PF03493
PharmGKB	PA38727	http://www.pharmgkb.org/do/serve?objId=PA38727&objCls=Gene
Phobius	swissprot:KCNU1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNU1_HUMAN
PhylomeDB	A8MYU2	http://phylomedb.org/?seqid=A8MYU2
ProteinModelPortal	A8MYU2	http://www.proteinmodelportal.org/query/uniprot/A8MYU2
PubMed	16421571	http://www.ncbi.nlm.nih.gov/pubmed/16421571
PubMed	23129643	http://www.ncbi.nlm.nih.gov/pubmed/23129643
PubMed	9452476	http://www.ncbi.nlm.nih.gov/pubmed/9452476
Reactome	R-HSA-1300642	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1300642
RefSeq	NP_001027006	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001027006
SMR	A8MYU2	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=A8MYU2
STRING	9606.ENSP00000382770	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000382770&targetmode=cogs
UCSC	uc010lvw	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010lvw&org=rat
UniGene	Hs.13861	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.13861
UniProtKB	KCNU1_HUMAN	http://www.uniprot.org/uniprot/KCNU1_HUMAN
UniProtKB-AC	A8MYU2	http://www.uniprot.org/uniprot/A8MYU2
charge	swissprot:KCNU1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNU1_HUMAN
eggNOG	ENOG410YUX1	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YUX1
eggNOG	KOG1420	http://eggnogapi.embl.de/nog_data/html/tree/KOG1420
epestfind	swissprot:KCNU1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNU1_HUMAN
garnier	swissprot:KCNU1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNU1_HUMAN
helixturnhelix	swissprot:KCNU1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNU1_HUMAN
hmoment	swissprot:KCNU1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNU1_HUMAN
iep	swissprot:KCNU1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNU1_HUMAN
inforesidue	swissprot:KCNU1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNU1_HUMAN
neXtProt	NX_A8MYU2	http://www.nextprot.org/db/entry/NX_A8MYU2
octanol	swissprot:KCNU1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNU1_HUMAN
pepcoil	swissprot:KCNU1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNU1_HUMAN
pepdigest	swissprot:KCNU1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNU1_HUMAN
pepinfo	swissprot:KCNU1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNU1_HUMAN
pepnet	swissprot:KCNU1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNU1_HUMAN
pepstats	swissprot:KCNU1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNU1_HUMAN
pepwheel	swissprot:KCNU1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNU1_HUMAN
pepwindow	swissprot:KCNU1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNU1_HUMAN
sigcleave	swissprot:KCNU1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNU1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SCN8A_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1 {ECO 0000269|PubMed 9828131}; IsoId=Q9UQD0-1; Sequence=Displayed; Name=2 {ECO 0000269|PubMed 9828131}; Synonyms=5A {ECO 0000269|PubMed 9828131}; IsoId=Q9UQD0-2; Sequence=VSP_050589, VSP_050590; Name=3 {ECO 0000269|PubMed 9828131}; IsoId=Q9UQD0-3; Sequence=VSP_050591; Name=4 {ECO 0000269|PubMed 9295353}; Synonyms=18N {ECO 0000269|PubMed 9295353}; IsoId=Q9UQD0-4; Sequence=VSP_050592, VSP_050593; Name=5; IsoId=Q9UQD0-5; Sequence=VSP_038651; 
# AltName	SCN8A_HUMAN	Sodium channel protein type VIII subunit alpha
# AltName	SCN8A_HUMAN	Voltage-gated sodium channel subunit alpha Nav1.6
# CCDS	CCDS44891	-. [Q9UQD0-1]
# CCDS	CCDS53794	-. [Q9UQD0-5]
# CCDS	CCDS81692	-. [Q9UQD0-2]
# ChiTaRS	SCN8A	human
# DISEASE	SCN8A_HUMAN	Cognitive impairment with or without cerebellar ataxia (CIAT) [MIM 614306]  A disorder characterized by markedly delayed cognitive and motor development, attention deficit disorder, and cerebellar ataxia. Features include bilateral esophoria, strabismatic amblyopia, unsustained gaze evoked nystagmus on horizontal gaze, ataxic gait, dysmetria in the upper limbs and dysarthria, with normal strength, tone, and reflexes. {ECO 0000269|PubMed 16236810}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCN8A_HUMAN	Epileptic encephalopathy, early infantile, 13 (EIEE13) [MIM 614558]  A form of epilepsy characterized by frequent tonic seizures or spasms beginning in infancy with a specific EEG finding of suppression-burst patterns, characterized by high- voltage bursts alternating with almost flat suppression phases. Patients may progress to West syndrome, which is characterized by tonic spasms with clustering, arrest of psychomotor development, and hypsarrhythmia on EEG. EIEE13 is a severe form consisting of early-onset seizures, features of autism, intellectual disability, ataxia, and sudden unexplained death in epilepsy. {ECO 0000269|PubMed 22365152, ECO 0000269|PubMed 24352161, ECO 0000269|PubMed 24874546, ECO 0000269|PubMed 24888894, ECO 0000269|PubMed 25239001, ECO 0000269|PubMed 25568300, ECO 0000269|PubMed 25725044, ECO 0000269|PubMed 25785782, ECO 0000269|PubMed 26900580, ECO 0000269|PubMed 27210545}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCN8A_HUMAN	Seizures, benign familial infantile, 5 (BFIS5) [MIM 617080]  A form of benign familial infantile epilepsy, a neurologic disorder characterized by afebrile seizures occurring in clusters during the first year of life, without neurologic sequelae. BFIS5 inheritance is autosomal dominant. {ECO 0000269|PubMed 26677014, ECO 0000269|PubMed 27210545}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	SCN8A_HUMAN	The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position. {ECO 0000305}. 
# DrugBank	DB00313	Valproic Acid
# Ensembl	ENST00000354534	ENSP00000346534; ENSG00000196876. [Q9UQD0-1]
# Ensembl	ENST00000355133	ENSP00000347255; ENSG00000196876. [Q9UQD0-5]
# Ensembl	ENST00000545061	ENSP00000440360; ENSG00000196876. [Q9UQD0-5]
# Ensembl	ENST00000599343	ENSP00000476447; ENSG00000196876. [Q9UQD0-3]
# Ensembl	ENST00000627620	ENSP00000487583; ENSG00000196876. [Q9UQD0-2]
# ExpressionAtlas	Q9UQD0	baseline and differential
# FUNCTION	SCN8A_HUMAN	Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation. {ECO 0000269|PubMed 19136557}. 
# GO_component	GO:0001518	voltage-gated sodium channel complex; IC:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_component	GO:0016023	cytoplasmic, membrane-bounded vesicle; IEA:UniProtKB-SubCell.
# GO_component	GO:0030018	Z disc; ISS:BHF-UCL.
# GO_component	GO:0033268	node of Ranvier; ISS:BHF-UCL.
# GO_component	GO:0043194	axon initial segment; ISS:BHF-UCL.
# GO_function	GO:0005248	voltage-gated sodium channel activity; IDA:UniProtKB.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_process	GO:0006814	sodium ion transport; NAS:UniProtKB.
# GO_process	GO:0007399	nervous system development; TAS:ProtInc.
# GO_process	GO:0007422	peripheral nervous system development; ISS:BHF-UCL.
# GO_process	GO:0019228	neuronal action potential; IBA:GO_Central.
# GO_process	GO:0042552	myelination; ISS:BHF-UCL.
# GO_process	GO:0086010	membrane depolarization during action potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# Gene3D	1.20.120.350	-; 4.
# Genevisible	Q9UQD0	HS
# HGNC	HGNC:10596	SCN8A
# InterPro	IPR000048	IQ_motif_EF-hand-BS
# InterPro	IPR001696	Na_channel_asu
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR008054	Na_channel_a8su
# InterPro	IPR010526	Na_trans_assoc
# InterPro	IPR024583	Na_trans_cytopl
# InterPro	IPR027359	Channel_four-helix_dom
# KEGG_Brite	ko04040	Ion channels
# MIM	600702	gene
# MIM	614306	phenotype
# MIM	614558	phenotype
# MIM	617080	phenotype
# Organism	SCN8A_HUMAN	Homo sapiens (Human)
# Orphanet	1934	Early infantile epileptic encephalopathy
# PRINTS	PR00170	NACHANNEL
# PRINTS	PR01667	NACHANNEL8
# PROSITE	PS50096	IQ
# PTM	SCN8A_HUMAN	May be ubiquitinated by NEDD4L; which would promote its endocytosis. {ECO 0000250}. 
# PTM	SCN8A_HUMAN	Phosphorylation at Ser-1497 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents. {ECO 0000250}. 
# Pfam	PF00520	Ion_trans; 4
# Pfam	PF00612	IQ
# Pfam	PF06512	Na_trans_assoc
# Pfam	PF11933	Na_trans_cytopl
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-445095	Interaction between L1 and Ankyrins
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# RecName	SCN8A_HUMAN	Sodium channel protein type 8 subunit alpha
# RefSeq	NP_001171455	NM_001177984.2. [Q9UQD0-5]
# RefSeq	NP_001317189	NM_001330260.1
# RefSeq	NP_055006	NM_014191.3. [Q9UQD0-1]
# RefSeq	XP_006719619	XM_006719556.3. [Q9UQD0-2]
# RefSeq	XP_011536953	XM_011538651.2. [Q9UQD0-2]
# RefSeq	XP_016875283	XM_017019794.1. [Q9UQD0-1]
# SIMILARITY	Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.6/SCN8A subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 IQ domain. {ECO:0000255|PROSITE- ProRule	PRU00116, ECO:0000305}.
# SMART	SM00015	IQ
# SUBCELLULAR LOCATION	SCN8A_HUMAN	Cell membrane {ECO 0000269|PubMed 19136557}; Multi-pass membrane protein {ECO 0000269|PubMed 19136557}. 
# SUBCELLULAR LOCATION	SCN8A_HUMAN	Isoform 5  Cytoplasmic vesicle. Note=Some vesicles are localized adjacent to melanoma invadopodia and macrophage podosomes. Does not localize to the plasma membrane. 
# SUBUNIT	SCN8A_HUMAN	Interacts with NEDD4 and NEDD4L (By similarity). Interacts with FGF13; may regulate SCN8A activity. Interacts with FGF14, GBG3, GBB2 and SCN1B (PubMed 26900580). {ECO 0000250|UniProtKB Q9WTU3, ECO 0000269|PubMed 15282281, ECO 0000269|PubMed 26900580}. 
# TCDB	1.A.1.10	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	Isoform 5 is expressed in non-neuronal tissues, such as monocytes/macrophages. {ECO:0000269|PubMed	19136557}. 
# UCSC	uc001ryw	human. [Q9UQD0-1]
# eggNOG	ENOG410XNP6	LUCA
# eggNOG	KOG2301	Eukaryota
BLAST	swissprot:SCN8A_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SCN8A_HUMAN
COXPRESdb	6334	http://coxpresdb.jp/data/gene/6334.shtml
CleanEx	HS_SCN8A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SCN8A
DOI	10.1002/acn3.276	http://dx.doi.org/10.1002/acn3.276
DOI	10.1002/ana.24580	http://dx.doi.org/10.1002/ana.24580
DOI	10.1006/geno.1998.5550	http://dx.doi.org/10.1006/geno.1998.5550
DOI	10.1016/j.ajhg.2012.01.006	http://dx.doi.org/10.1016/j.ajhg.2012.01.006
DOI	10.1016/j.ejpn.2016.04.015	http://dx.doi.org/10.1016/j.ejpn.2016.04.015
DOI	10.1016/j.eplepsyres.2014.08.020	http://dx.doi.org/10.1016/j.eplepsyres.2014.08.020
DOI	10.1016/j.nbd.2014.05.017	http://dx.doi.org/10.1016/j.nbd.2014.05.017
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1074/jbc.272.38.24008	http://dx.doi.org/10.1074/jbc.272.38.24008
DOI	10.1074/jbc.M801892200	http://dx.doi.org/10.1074/jbc.M801892200
DOI	10.1111/epi.12668	http://dx.doi.org/10.1111/epi.12668
DOI	10.1111/epi.12925	http://dx.doi.org/10.1111/epi.12925
DOI	10.1136/jmedgenet-2014-102813	http://dx.doi.org/10.1136/jmedgenet-2014-102813
DOI	10.1136/jmg.2005.035667	http://dx.doi.org/10.1136/jmg.2005.035667
DOI	10.1177/0883073813511300	http://dx.doi.org/10.1177/0883073813511300
DOI	10.1212/WNL.0000000000001211	http://dx.doi.org/10.1212/WNL.0000000000001211
DOI	10.1523/JNEUROSCI.1628-04.2004	http://dx.doi.org/10.1523/JNEUROSCI.1628-04.2004
DrugBank	DB00313	http://www.drugbank.ca/drugs/DB00313
EMBL	AB027567	http://www.ebi.ac.uk/ena/data/view/AB027567
EMBL	AC013421	http://www.ebi.ac.uk/ena/data/view/AC013421
EMBL	AC025097	http://www.ebi.ac.uk/ena/data/view/AC025097
EMBL	AC068987	http://www.ebi.ac.uk/ena/data/view/AC068987
EMBL	AC140060	http://www.ebi.ac.uk/ena/data/view/AC140060
EMBL	AF049618	http://www.ebi.ac.uk/ena/data/view/AF049618
EMBL	AF050711	http://www.ebi.ac.uk/ena/data/view/AF050711
EMBL	AF050712	http://www.ebi.ac.uk/ena/data/view/AF050712
EMBL	AF050713	http://www.ebi.ac.uk/ena/data/view/AF050713
EMBL	AF050714	http://www.ebi.ac.uk/ena/data/view/AF050714
EMBL	AF050715	http://www.ebi.ac.uk/ena/data/view/AF050715
EMBL	AF050716	http://www.ebi.ac.uk/ena/data/view/AF050716
EMBL	AF050717	http://www.ebi.ac.uk/ena/data/view/AF050717
EMBL	AF050718	http://www.ebi.ac.uk/ena/data/view/AF050718
EMBL	AF050719	http://www.ebi.ac.uk/ena/data/view/AF050719
EMBL	AF050720	http://www.ebi.ac.uk/ena/data/view/AF050720
EMBL	AF050721	http://www.ebi.ac.uk/ena/data/view/AF050721
EMBL	AF050722	http://www.ebi.ac.uk/ena/data/view/AF050722
EMBL	AF050723	http://www.ebi.ac.uk/ena/data/view/AF050723
EMBL	AF050724	http://www.ebi.ac.uk/ena/data/view/AF050724
EMBL	AF050725	http://www.ebi.ac.uk/ena/data/view/AF050725
EMBL	AF050726	http://www.ebi.ac.uk/ena/data/view/AF050726
EMBL	AF050727	http://www.ebi.ac.uk/ena/data/view/AF050727
EMBL	AF050728	http://www.ebi.ac.uk/ena/data/view/AF050728
EMBL	AF050729	http://www.ebi.ac.uk/ena/data/view/AF050729
EMBL	AF050730	http://www.ebi.ac.uk/ena/data/view/AF050730
EMBL	AF050731	http://www.ebi.ac.uk/ena/data/view/AF050731
EMBL	AF050732	http://www.ebi.ac.uk/ena/data/view/AF050732
EMBL	AF050733	http://www.ebi.ac.uk/ena/data/view/AF050733
EMBL	AF050734	http://www.ebi.ac.uk/ena/data/view/AF050734
EMBL	AF050735	http://www.ebi.ac.uk/ena/data/view/AF050735
EMBL	AF050736	http://www.ebi.ac.uk/ena/data/view/AF050736
EMBL	AF225988	http://www.ebi.ac.uk/ena/data/view/AF225988
EMBL	FJ611941	http://www.ebi.ac.uk/ena/data/view/FJ611941
Ensembl	ENST00000354534	http://www.ensembl.org/id/ENST00000354534
Ensembl	ENST00000355133	http://www.ensembl.org/id/ENST00000355133
Ensembl	ENST00000545061	http://www.ensembl.org/id/ENST00000545061
Ensembl	ENST00000599343	http://www.ensembl.org/id/ENST00000599343
Ensembl	ENST00000627620	http://www.ensembl.org/id/ENST00000627620
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0001518	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001518
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016023	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016023
GO_component	GO:0030018	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030018
GO_component	GO:0033268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033268
GO_component	GO:0043194	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043194
GO_function	GO:0005248	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005248
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0007399	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007399
GO_process	GO:0007422	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007422
GO_process	GO:0019228	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019228
GO_process	GO:0042552	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042552
GO_process	GO:0086010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086010
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	SCN8A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SCN8A
GeneID	6334	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6334
GeneTree	ENSGT00830000128242	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00830000128242
HGNC	HGNC:10596	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10596
HOGENOM	HOG000231755	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231755&db=HOGENOM6
HOVERGEN	HBG053100	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053100&db=HOVERGEN
InParanoid	Q9UQD0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UQD0
IntAct	Q9UQD0	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9UQD0*
InterPro	IPR000048	http://www.ebi.ac.uk/interpro/entry/IPR000048
InterPro	IPR001696	http://www.ebi.ac.uk/interpro/entry/IPR001696
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR008054	http://www.ebi.ac.uk/interpro/entry/IPR008054
InterPro	IPR010526	http://www.ebi.ac.uk/interpro/entry/IPR010526
InterPro	IPR024583	http://www.ebi.ac.uk/interpro/entry/IPR024583
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
Jabion	6334	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6334
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:6334	http://www.genome.jp/dbget-bin/www_bget?hsa:6334
KEGG_Orthology	KO:K04840	http://www.genome.jp/dbget-bin/www_bget?KO:K04840
MIM	600702	http://www.ncbi.nlm.nih.gov/omim/600702
MIM	614306	http://www.ncbi.nlm.nih.gov/omim/614306
MIM	614558	http://www.ncbi.nlm.nih.gov/omim/614558
MIM	617080	http://www.ncbi.nlm.nih.gov/omim/617080
OMA	GFICKKT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GFICKKT
Orphanet	1934	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1934
OrthoDB	EOG091G00FK	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00FK
PRINTS	PR00170	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00170
PRINTS	PR01667	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01667
PROSITE	PS50096	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50096
PSORT	swissprot:SCN8A_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SCN8A_HUMAN
PSORT-B	swissprot:SCN8A_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SCN8A_HUMAN
PSORT2	swissprot:SCN8A_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SCN8A_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF00612	http://pfam.xfam.org/family/PF00612
Pfam	PF06512	http://pfam.xfam.org/family/PF06512
Pfam	PF11933	http://pfam.xfam.org/family/PF11933
PharmGKB	PA35009	http://www.pharmgkb.org/do/serve?objId=PA35009&objCls=Gene
Phobius	swissprot:SCN8A_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SCN8A_HUMAN
PhylomeDB	Q9UQD0	http://phylomedb.org/?seqid=Q9UQD0
ProteinModelPortal	Q9UQD0	http://www.proteinmodelportal.org/query/uniprot/Q9UQD0
PubMed	15282281	http://www.ncbi.nlm.nih.gov/pubmed/15282281
PubMed	16236810	http://www.ncbi.nlm.nih.gov/pubmed/16236810
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	19136557	http://www.ncbi.nlm.nih.gov/pubmed/19136557
PubMed	22365152	http://www.ncbi.nlm.nih.gov/pubmed/22365152
PubMed	24352161	http://www.ncbi.nlm.nih.gov/pubmed/24352161
PubMed	24874546	http://www.ncbi.nlm.nih.gov/pubmed/24874546
PubMed	24888894	http://www.ncbi.nlm.nih.gov/pubmed/24888894
PubMed	25239001	http://www.ncbi.nlm.nih.gov/pubmed/25239001
PubMed	25568300	http://www.ncbi.nlm.nih.gov/pubmed/25568300
PubMed	25725044	http://www.ncbi.nlm.nih.gov/pubmed/25725044
PubMed	25785782	http://www.ncbi.nlm.nih.gov/pubmed/25785782
PubMed	26677014	http://www.ncbi.nlm.nih.gov/pubmed/26677014
PubMed	26900580	http://www.ncbi.nlm.nih.gov/pubmed/26900580
PubMed	27210545	http://www.ncbi.nlm.nih.gov/pubmed/27210545
PubMed	9295353	http://www.ncbi.nlm.nih.gov/pubmed/9295353
PubMed	9828131	http://www.ncbi.nlm.nih.gov/pubmed/9828131
Reactome	R-HSA-445095	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-445095
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
RefSeq	NP_001171455	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001171455
RefSeq	NP_001317189	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001317189
RefSeq	NP_055006	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055006
RefSeq	XP_006719619	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006719619
RefSeq	XP_011536953	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011536953
RefSeq	XP_016875283	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016875283
SMART	SM00015	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00015
STRING	9606.ENSP00000346534	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000346534&targetmode=cogs
TCDB	1.A.1.10	http://www.tcdb.org/search/result.php?tc=1.A.1.10
UCSC	uc001ryw	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001ryw&org=rat
UniGene	Hs.436550	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.436550
UniGene	Hs.710638	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.710638
UniProtKB	SCN8A_HUMAN	http://www.uniprot.org/uniprot/SCN8A_HUMAN
UniProtKB-AC	Q9UQD0	http://www.uniprot.org/uniprot/Q9UQD0
charge	swissprot:SCN8A_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SCN8A_HUMAN
eggNOG	ENOG410XNP6	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNP6
eggNOG	KOG2301	http://eggnogapi.embl.de/nog_data/html/tree/KOG2301
epestfind	swissprot:SCN8A_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SCN8A_HUMAN
garnier	swissprot:SCN8A_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SCN8A_HUMAN
helixturnhelix	swissprot:SCN8A_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SCN8A_HUMAN
hmoment	swissprot:SCN8A_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SCN8A_HUMAN
iep	swissprot:SCN8A_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SCN8A_HUMAN
inforesidue	swissprot:SCN8A_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SCN8A_HUMAN
neXtProt	NX_Q9UQD0	http://www.nextprot.org/db/entry/NX_Q9UQD0
octanol	swissprot:SCN8A_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SCN8A_HUMAN
pepcoil	swissprot:SCN8A_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SCN8A_HUMAN
pepdigest	swissprot:SCN8A_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SCN8A_HUMAN
pepinfo	swissprot:SCN8A_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SCN8A_HUMAN
pepnet	swissprot:SCN8A_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SCN8A_HUMAN
pepstats	swissprot:SCN8A_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SCN8A_HUMAN
pepwheel	swissprot:SCN8A_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SCN8A_HUMAN
pepwindow	swissprot:SCN8A_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SCN8A_HUMAN
sigcleave	swissprot:SCN8A_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SCN8A_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TRPV5_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NQA5-1; Sequence=Displayed; Name=2; IsoId=Q9NQA5-2; Sequence=VSP_057199, VSP_057200; Note=No experimental confirmation available.; 
# AltName	TRPV5_HUMAN	Calcium transport protein 2
# AltName	TRPV5_HUMAN	Epithelial calcium channel 1
# AltName	TRPV5_HUMAN	Osm-9-like TRP channel 3
# BioGrid	121137	20
# CCDS	CCDS5875	-. [Q9NQA5-1]
# ENZYME REGULATION	Activated by WNK3. {ECO:0000269|PubMed	18768590}. 
# Ensembl	ENST00000442623	ENSP00000406572; ENSG00000127412
# ExpressionAtlas	Q9NQA5	baseline and differential
# FUNCTION	TRPV5_HUMAN	Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed 11549322, PubMed 18768590). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (PubMed 11549322, PubMed 18768590). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity). {ECO 0000250|UniProtKB P69744, ECO 0000250|UniProtKB Q9XSM3, ECO 0000269|PubMed 11549322, ECO 0000269|PubMed 18768590}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0005262	calcium channel activity; IDA:UniProtKB.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0006816	calcium ion transport; ISS:UniProtKB.
# GO_process	GO:0035809	regulation of urine volume; ISS:UniProtKB.
# GO_process	GO:0051262	protein tetramerization; ISS:UniProtKB.
# GO_process	GO:0055074	calcium ion homeostasis; ISS:UniProtKB.
# GO_process	GO:0070588	calcium ion transmembrane transport; IDA:UniProtKB.
# GO_process	GO:1990035	calcium ion import into cell; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.25.40.20	-; 2.
# Genevisible	Q9NQA5	HS
# HGNC	HGNC:3145	TRPV5
# INTERACTION	TRPV5_HUMAN	P05937 CALB1; NbExp=4; IntAct=EBI-751281, EBI-4286943; 
# IntAct	Q9NQA5	2
# InterPro	IPR002110	Ankyrin_rpt
# InterPro	IPR004729	TRP_channel
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR008344	TRPV5/TRPV6
# InterPro	IPR008346	TRPV5
# InterPro	IPR020683	Ankyrin_rpt-contain_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04961	Endocrine and other factor-regulated calcium reabsorption
# MIM	606679	gene
# Organism	TRPV5_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10582:SF11	PTHR10582:SF11
# PRINTS	PR01415	ANKYRIN
# PRINTS	PR01765	ECACCHANNEL
# PRINTS	PR01767	ECACCHANNEL2
# PROSITE	PS50088	ANK_REPEAT; 2
# PROSITE	PS50297	ANK_REP_REGION
# PTM	TRPV5_HUMAN	Glycosylated. {ECO 0000269|PubMed 18768590}. 
# Pfam	PF00023	Ank
# Pfam	PF00520	Ion_trans
# Pfam	PF12796	Ank_2
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-3295583	TRP channels
# RecName	TRPV5_HUMAN	Transient receptor potential cation channel subfamily V member 5
# RefSeq	NP_062815	NM_019841.6
# SIMILARITY	Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV5 sub-subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 6 ANK repeats. {ECO:0000255|PROSITE- ProRule	PRU00023}. 
# SMART	SM00248	ANK; 5
# SUBCELLULAR LOCATION	TRPV5_HUMAN	Apical cell membrane {ECO 0000269|PubMed 18768590}; Multi-pass membrane protein {ECO 0000269|PubMed 18768590}. Note=Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells (By similarity). The expression of the glycosylated form in the cell membrane is increased in the presence of WNK3 (PubMed 18768590). {ECO 0000250|UniProtKB P69744, ECO 0000269|PubMed 18768590}. 
# SUBUNIT	TRPV5_HUMAN	Homotetramer and probably heterotetramer with TRPV6. Interacts with TRPV6 (By similarity). Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with calmodulin. Interacts with BSPRY, which results in its inactivation. {ECO 0000250|UniProtKB P69744, ECO 0000250|UniProtKB Q9XSM3}. 
# SUPFAM	SSF48403	SSF48403
# TCDB	1.A.4.2.10	the transient receptor potential ca(2+) channel (trp-cc) family
# TIGRFAMs	TIGR00870	trp
# TISSUE SPECIFICITY	TRPV5_HUMAN	Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum. {ECO 0000269|PubMed 10945469, ECO 0000269|PubMed 11549322}. 
# UCSC	uc003wbz	human. [Q9NQA5-1]
# WEB RESOURCE	TRPV5_HUMAN	Name=SeattleSNPs; URL="http //pga.gs.washington.edu/data/trpv5/";
# eggNOG	ENOG4110DG4	LUCA
# eggNOG	KOG3676	Eukaryota
BLAST	swissprot:TRPV5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TRPV5_HUMAN
BioCyc	ZFISH:ENSG00000127412-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000127412-MONOMER
COXPRESdb	56302	http://coxpresdb.jp/data/gene/56302.shtml
CleanEx	HS_TRPV5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TRPV5
DOI	10.1006/geno.2000.6203	http://dx.doi.org/10.1006/geno.2000.6203
DOI	10.1006/geno.2001.6606	http://dx.doi.org/10.1006/geno.2001.6606
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1083423	http://dx.doi.org/10.1126/science.1083423
DOI	10.1152/ajprenal.90229.2008	http://dx.doi.org/10.1152/ajprenal.90229.2008
EMBL	AC245427	http://www.ebi.ac.uk/ena/data/view/AC245427
EMBL	AF304464	http://www.ebi.ac.uk/ena/data/view/AF304464
EMBL	AJ271207	http://www.ebi.ac.uk/ena/data/view/AJ271207
EMBL	AJ487965	http://www.ebi.ac.uk/ena/data/view/AJ487965
EMBL	AY206695	http://www.ebi.ac.uk/ena/data/view/AY206695
EMBL	BC034740	http://www.ebi.ac.uk/ena/data/view/BC034740
EMBL	CH236959	http://www.ebi.ac.uk/ena/data/view/CH236959
EMBL	CH471198	http://www.ebi.ac.uk/ena/data/view/CH471198
Ensembl	ENST00000442623	http://www.ensembl.org/id/ENST00000442623
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0035809	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035809
GO_process	GO:0051262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051262
GO_process	GO:0055074	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055074
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:1990035	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990035
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.25.40.20	http://www.cathdb.info/version/latest/superfamily/1.25.40.20
GeneCards	TRPV5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TRPV5
GeneID	56302	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56302
HGNC	HGNC:3145	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:3145
HOGENOM	HOG000207344	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000207344&db=HOGENOM6
HOVERGEN	HBG061442	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG061442&db=HOVERGEN
HPA	HPA063175	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA063175
InParanoid	Q9NQA5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NQA5
IntAct	Q9NQA5	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NQA5*
InterPro	IPR002110	http://www.ebi.ac.uk/interpro/entry/IPR002110
InterPro	IPR004729	http://www.ebi.ac.uk/interpro/entry/IPR004729
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR008344	http://www.ebi.ac.uk/interpro/entry/IPR008344
InterPro	IPR008346	http://www.ebi.ac.uk/interpro/entry/IPR008346
InterPro	IPR020683	http://www.ebi.ac.uk/interpro/entry/IPR020683
Jabion	56302	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=56302
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:56302	http://www.genome.jp/dbget-bin/www_bget?hsa:56302
KEGG_Orthology	KO:K04974	http://www.genome.jp/dbget-bin/www_bget?KO:K04974
KEGG_Pathway	ko04961	http://www.genome.jp/kegg-bin/show_pathway?ko04961
MIM	606679	http://www.ncbi.nlm.nih.gov/omim/606679
MINT	MINT-1470011	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1470011
PANTHER	PTHR10582:SF11	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10582:SF11
PRINTS	PR01415	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01415
PRINTS	PR01765	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01765
PRINTS	PR01767	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01767
PROSITE	PS50088	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50088
PROSITE	PS50297	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50297
PSORT	swissprot:TRPV5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TRPV5_HUMAN
PSORT-B	swissprot:TRPV5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TRPV5_HUMAN
PSORT2	swissprot:TRPV5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TRPV5_HUMAN
Pfam	PF00023	http://pfam.xfam.org/family/PF00023
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF12796	http://pfam.xfam.org/family/PF12796
PharmGKB	PA35045	http://www.pharmgkb.org/do/serve?objId=PA35045&objCls=Gene
Phobius	swissprot:TRPV5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TRPV5_HUMAN
PhylomeDB	Q9NQA5	http://phylomedb.org/?seqid=Q9NQA5
ProteinModelPortal	Q9NQA5	http://www.proteinmodelportal.org/query/uniprot/Q9NQA5
PubMed	10945469	http://www.ncbi.nlm.nih.gov/pubmed/10945469
PubMed	11549322	http://www.ncbi.nlm.nih.gov/pubmed/11549322
PubMed	12690205	http://www.ncbi.nlm.nih.gov/pubmed/12690205
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18768590	http://www.ncbi.nlm.nih.gov/pubmed/18768590
Reactome	R-HSA-3295583	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3295583
RefSeq	NP_062815	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_062815
SMART	SM00248	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00248
SMR	Q9NQA5	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9NQA5
STRING	9606.ENSP00000265310	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000265310&targetmode=cogs
SUPFAM	SSF48403	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48403
TCDB	1.A.4.2.10	http://www.tcdb.org/search/result.php?tc=1.A.4.2.10
TIGRFAMs	TIGR00870	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00870
UCSC	uc003wbz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003wbz&org=rat
UniGene	Hs.283369	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.283369
UniProtKB	TRPV5_HUMAN	http://www.uniprot.org/uniprot/TRPV5_HUMAN
UniProtKB-AC	Q9NQA5	http://www.uniprot.org/uniprot/Q9NQA5
charge	swissprot:TRPV5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TRPV5_HUMAN
eggNOG	ENOG4110DG4	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110DG4
eggNOG	KOG3676	http://eggnogapi.embl.de/nog_data/html/tree/KOG3676
epestfind	swissprot:TRPV5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TRPV5_HUMAN
garnier	swissprot:TRPV5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TRPV5_HUMAN
helixturnhelix	swissprot:TRPV5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRPV5_HUMAN
hmoment	swissprot:TRPV5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TRPV5_HUMAN
iep	swissprot:TRPV5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TRPV5_HUMAN
inforesidue	swissprot:TRPV5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TRPV5_HUMAN
neXtProt	NX_Q9NQA5	http://www.nextprot.org/db/entry/NX_Q9NQA5
octanol	swissprot:TRPV5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TRPV5_HUMAN
pepcoil	swissprot:TRPV5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TRPV5_HUMAN
pepdigest	swissprot:TRPV5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TRPV5_HUMAN
pepinfo	swissprot:TRPV5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TRPV5_HUMAN
pepnet	swissprot:TRPV5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TRPV5_HUMAN
pepstats	swissprot:TRPV5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TRPV5_HUMAN
pepwheel	swissprot:TRPV5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TRPV5_HUMAN
pepwindow	swissprot:TRPV5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TRPV5_HUMAN
sigcleave	swissprot:TRPV5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TRPV5_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	113582	2
# DISEASE	BSND_HUMAN	Bartter syndrome 4A, neonatal, with sensorineural deafness (BARTS4A) [MIM 602522]  A form of Bartter syndrome, an autosomal recessive disorder characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BARTS4A is associated with sensorineural deafness. {ECO 0000269|PubMed 11687798, ECO 0000269|PubMed 12574213}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000371265	ENSP00000360312; ENSG00000162399
# ExpressionAtlas	Q8WZ55	baseline and differential
# FUNCTION	BSND_HUMAN	Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stria, CLCNK/BSND channels drive potassium secretion by recycling chloride for the basolateral SLC12A2 cotransporter. {ECO 0000269|PubMed 11734858, ECO 0000269|PubMed 12111250}. 
# GO_component	GO:0005737	cytoplasm; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; ISS:UniProtKB.
# GO_component	GO:0016323	basolateral plasma membrane; ISS:UniProtKB.
# GO_component	GO:0043234	protein complex; ISS:UniProtKB.
# GO_function	GO:0005247	voltage-gated chloride channel activity; TAS:Reactome.
# GO_function	GO:0017081	chloride channel regulator activity; IEA:Ensembl.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q8WZ55	HS
# HGNC	HGNC:16512	BSND
# IntAct	Q8WZ55	2
# InterPro	IPR029181	Barttin_dom
# KEGG_Disease	H00239	[Endocrine disease; Urinary system disease] Bartter syndrome
# MIM	602522	phenotype
# MIM	606412	gene
# Organism	BSND_HUMAN	Homo sapiens (Human)
# Orphanet	89938	Infantile Bartter syndrome with sensorineural deafness
# Orphanet	90636	Autosomal recessive non-syndromic sensorineural deafness type DFNB
# PTM	BSND_HUMAN	Palmitoylation is necessary for activation of plasma membrane-inserted CLC-K/barttin channels. {ECO 0000269|PubMed 26013830}. 
# Pfam	PF15462	Barttin
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	BSND_HUMAN	Barttin
# RefSeq	NP_476517	NM_057176.2
# SEQUENCE CAUTION	Sequence=BC069510; Type=Frameshift; Positions=Several; Evidence={ECO	0000305};
# SUBCELLULAR LOCATION	BSND_HUMAN	Cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Cytoplasm {ECO 0000250}. Note=A significant amount also observed intracellularly. Staining in membranes of the renal tubule and of potassium-secreting epithelia of the inner ear is basolateral (By similarity). {ECO 0000250}. 
# SUBUNIT	Interacts with CLCNK channels. Forms heteromers with CLCNKA in the thin ascending limb of Henle and with CLCNKB in the thick ascending limb and more distal segments (By similarity). {ECO	0000250}. 
# TCDB	8.A.53.1	the clc-k accessory subunit, barttin, (barttin) family
# TISSUE SPECIFICITY	Expressed primarily in kidney. Expressed in specific nephron segments and in the stria vascularis of the inner ear. {ECO:0000269|PubMed	11687798}. 
# UCSC	uc001cye	human
# eggNOG	ENOG410J53T	Eukaryota
# eggNOG	ENOG410ZGZV	LUCA
BLAST	swissprot:BSND_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:BSND_HUMAN
BioCyc	ZFISH:ENSG00000162399-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000162399-MONOMER
COXPRESdb	7809	http://coxpresdb.jp/data/gene/7809.shtml
CleanEx	HS_BSND	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_BSND
DOI	10.1007/s00418-003-0535-2	http://dx.doi.org/10.1007/s00418-003-0535-2
DOI	10.1007/s00424-002-0819-8	http://dx.doi.org/10.1007/s00424-002-0819-8
DOI	10.1038/35107099	http://dx.doi.org/10.1038/35107099
DOI	10.1038/ng752	http://dx.doi.org/10.1038/ng752
DOI	10.1074/jbc.M114.631705	http://dx.doi.org/10.1074/jbc.M114.631705
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1210/jc.2002-021398	http://dx.doi.org/10.1210/jc.2002-021398
EMBL	AY034632	http://www.ebi.ac.uk/ena/data/view/AY034632
EMBL	BC069510	http://www.ebi.ac.uk/ena/data/view/BC069510
Ensembl	ENST00000371265	http://www.ensembl.org/id/ENST00000371265
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GO_function	GO:0005247	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005247
GO_function	GO:0017081	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017081
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	BSND	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=BSND
GeneID	7809	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7809
GeneTree	ENSGT00390000008549	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000008549
HGNC	HGNC:16512	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16512
HOGENOM	HOG000049268	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000049268&db=HOGENOM6
HOVERGEN	HBG050739	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050739&db=HOVERGEN
HPA	HPA053836	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA053836
InParanoid	Q8WZ55	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8WZ55
IntAct	Q8WZ55	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8WZ55*
InterPro	IPR029181	http://www.ebi.ac.uk/interpro/entry/IPR029181
Jabion	7809	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7809
KEGG_Disease	H00239	http://www.genome.jp/dbget-bin/www_bget?H00239
KEGG_Gene	hsa:7809	http://www.genome.jp/dbget-bin/www_bget?hsa:7809
MIM	602522	http://www.ncbi.nlm.nih.gov/omim/602522
MIM	606412	http://www.ncbi.nlm.nih.gov/omim/606412
MINT	MINT-4536104	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4536104
OMA	DFSHIQM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DFSHIQM
Orphanet	89938	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=89938
Orphanet	90636	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=90636
OrthoDB	EOG091G0IJM	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0IJM
PSORT	swissprot:BSND_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:BSND_HUMAN
PSORT-B	swissprot:BSND_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:BSND_HUMAN
PSORT2	swissprot:BSND_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:BSND_HUMAN
Pfam	PF15462	http://pfam.xfam.org/family/PF15462
PharmGKB	PA134911659	http://www.pharmgkb.org/do/serve?objId=PA134911659&objCls=Gene
Phobius	swissprot:BSND_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:BSND_HUMAN
PhylomeDB	Q8WZ55	http://phylomedb.org/?seqid=Q8WZ55
ProteinModelPortal	Q8WZ55	http://www.proteinmodelportal.org/query/uniprot/Q8WZ55
PubMed	11687798	http://www.ncbi.nlm.nih.gov/pubmed/11687798
PubMed	11734858	http://www.ncbi.nlm.nih.gov/pubmed/11734858
PubMed	12111250	http://www.ncbi.nlm.nih.gov/pubmed/12111250
PubMed	12574213	http://www.ncbi.nlm.nih.gov/pubmed/12574213
PubMed	12761627	http://www.ncbi.nlm.nih.gov/pubmed/12761627
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	26013830	http://www.ncbi.nlm.nih.gov/pubmed/26013830
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_476517	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_476517
STRING	9606.ENSP00000360312	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000360312&targetmode=cogs
TCDB	8.A.53.1	http://www.tcdb.org/search/result.php?tc=8.A.53.1
UCSC	uc001cye	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001cye&org=rat
UniGene	Hs.151291	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.151291
UniProtKB	BSND_HUMAN	http://www.uniprot.org/uniprot/BSND_HUMAN
UniProtKB-AC	Q8WZ55	http://www.uniprot.org/uniprot/Q8WZ55
charge	swissprot:BSND_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:BSND_HUMAN
eggNOG	ENOG410J53T	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410J53T
eggNOG	ENOG410ZGZV	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZGZV
epestfind	swissprot:BSND_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:BSND_HUMAN
garnier	swissprot:BSND_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:BSND_HUMAN
helixturnhelix	swissprot:BSND_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:BSND_HUMAN
hmoment	swissprot:BSND_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:BSND_HUMAN
iep	swissprot:BSND_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:BSND_HUMAN
inforesidue	swissprot:BSND_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:BSND_HUMAN
neXtProt	NX_Q8WZ55	http://www.nextprot.org/db/entry/NX_Q8WZ55
octanol	swissprot:BSND_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:BSND_HUMAN
pepcoil	swissprot:BSND_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:BSND_HUMAN
pepdigest	swissprot:BSND_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:BSND_HUMAN
pepinfo	swissprot:BSND_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:BSND_HUMAN
pepnet	swissprot:BSND_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:BSND_HUMAN
pepstats	swissprot:BSND_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:BSND_HUMAN
pepwheel	swissprot:BSND_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:BSND_HUMAN
pepwindow	swissprot:BSND_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:BSND_HUMAN
sigcleave	swissprot:BSND_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:BSND_HUMAN
## Database	ID	URL or Descriptions
# AltName	EBP_HUMAN	Cholestenol Delta-isomerase
# AltName	EBP_HUMAN	Delta(8)-Delta(7) sterol isomerase
# AltName	EBP_HUMAN	Emopamil-binding protein
# BRENDA	5.3.3	2681
# BioGrid	115921	38
# CATALYTIC ACTIVITY	EBP_HUMAN	5-alpha-cholest-7-en-3-beta-ol = 5-alpha- cholest-8-en-3-beta-ol. {ECO 0000269|PubMed 12760743, ECO 0000269|PubMed 8798407, ECO 0000269|PubMed 9894009}. 
# DISEASE	EBP_HUMAN	Chondrodysplasia punctata 2, X-linked dominant (CDPX2) [MIM 302960]  A clinically and genetically heterogeneous disorder characterized by punctiform calcification of the bones. The key clinical features of CDPX2 are chondrodysplasia punctata, linear ichthyosis, cataracts and short stature. CDPX2 is a rare disorder of defective cholesterol biosynthesis, biochemically characterized by an increased amount of 8-dehydrocholesterol and cholest-8(9)- en-3-beta-ol in the plasma and tissues. {ECO 0000269|PubMed 10391218, ECO 0000269|PubMed 10391219, ECO 0000269|PubMed 10942423, ECO 0000269|PubMed 11493318, ECO 0000269|PubMed 18176751, ECO 0000269|PubMed 25814754}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	EBP_HUMAN	MEND syndrome (MEND) [MIM 300960]  An X-linked recessive disorder associated with a defect in sterol biosynthesis. Disease manifestations and severity are highly variable. Clinical features include intellectual disability, short stature, scoliosis, digital abnormalities, cataracts, and dermatologic abnormalities. {ECO 0000269|PubMed 12503101, ECO 0000269|PubMed 20949533, ECO 0000269|PubMed 24459067, ECO 0000269|PubMed 24700572}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00675	Tamoxifen
# Ensembl	ENST00000495186	ENSP00000417052; ENSG00000147155
# ExpressionAtlas	Q15125	baseline and differential
# FUNCTION	EBP_HUMAN	Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers. {ECO 0000269|PubMed 12760743, ECO 0000269|PubMed 8798407, ECO 0000269|PubMed 9894009}. 
# GO_component	GO:0005635	nuclear envelope; IDA:UniProtKB.
# GO_component	GO:0005783	endoplasmic reticulum; IDA:UniProtKB.
# GO_component	GO:0005789	endoplasmic reticulum membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016023	cytoplasmic, membrane-bounded vesicle; IEA:UniProtKB-SubCell.
# GO_function	GO:0000247	C-8 sterol isomerase activity; IEA:Ensembl.
# GO_function	GO:0004769	steroid delta-isomerase activity; IDA:UniProtKB.
# GO_function	GO:0004888	transmembrane signaling receptor activity; TAS:ProtInc.
# GO_function	GO:0015238	drug transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0047750	cholestenol delta-isomerase activity; IEA:UniProtKB-EC.
# GO_process	GO:0001501	skeletal system development; TAS:ProtInc.
# GO_process	GO:0006695	cholesterol biosynthetic process; IDA:UniProtKB.
# GO_process	GO:0008203	cholesterol metabolic process; TAS:ProtInc.
# GO_process	GO:0030097	hemopoiesis; IEA:Ensembl.
# GO_process	GO:0033489	cholesterol biosynthetic process via desmosterol; TAS:Reactome.
# GO_process	GO:0033490	cholesterol biosynthetic process via lathosterol; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005635	nuclear envelope
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0016853	isomerase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0048856	anatomical structure development
# Genevisible	Q15125	HS
# HGNC	HGNC:3133	EBP
# IntAct	Q15125	14
# InterPro	IPR007905	EBP
# InterPro	IPR033118	EXPERA
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Disease	H01194	[Inherited metabolic disease; Musculoskeletal disease] X-linked dominant chondrodysplasia punctata (CDPX2)
# KEGG_Pathway	ko00100	Steroid biosynthesis
# MIM	300205	gene
# MIM	300960	phenotype
# MIM	302960	phenotype
# MISCELLANEOUS	EBP_HUMAN	Binds to the phenylalkylamine calcium-ion antagonist emopamil, an anti-ischemic drug. 
# Organism	EBP_HUMAN	Homo sapiens (Human)
# Orphanet	35173	X-linked dominant chondrodysplasia punctata
# Orphanet	352487	Digital anomalies - intellectual disability - short stature
# Orphanet	401973	MEND syndrome
# PANTHER	PTHR14207	PTHR14207
# PATHWAY	EBP_HUMAN	Steroid biosynthesis; cholesterol biosynthesis. {ECO 0000269|PubMed 12760743, ECO 0000269|PubMed 8798407, ECO 0000269|PubMed 9894009}. 
# PIR	B56122	B56122
# PROSITE	PS51751	EXPERA
# Pfam	PF05241	EBP
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-6807047	Cholesterol biosynthesis via desmosterol
# Reactome	R-HSA-6807062	Cholesterol biosynthesis via lathosterol
# RecName	EBP_HUMAN	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
# RefSeq	NP_006570	NM_006579.2
# SIMILARITY	Belongs to the EBP family. {ECO	0000305}. 
# SIMILARITY	Contains 1 EXPERA domain. {ECO:0000255|PROSITE- ProRule	PRU01087}.
# SUBCELLULAR LOCATION	EBP_HUMAN	Endoplasmic reticulum membrane {ECO 0000269|PubMed 10406945}; Multi-pass membrane protein {ECO 0000305}. Nucleus envelope {ECO 0000269|PubMed 10406945}. Cytoplasmic vesicle {ECO 0000269|PubMed 10406945}. Note=During interphase, detected on the endoplasmic reticulum and the nuclear envelope. During mitosis, detected on cytoplasmic vesicles. {ECO 0000269|PubMed 10406945}. 
# UCSC	uc004djx	human
# eggNOG	ENOG41101ES	LUCA
# eggNOG	KOG4826	Eukaryota
BLAST	swissprot:EBP_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:EBP_HUMAN
BioCyc	MetaCyc:ENSG00000147155-MONOMER	http://biocyc.org/getid?id=MetaCyc:ENSG00000147155-MONOMER
BioCyc	ZFISH:ENSG00000147155-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000147155-MONOMER
COXPRESdb	10682	http://coxpresdb.jp/data/gene/10682.shtml
CleanEx	HS_EBP	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_EBP
DOI	10.1002/ajmg.a.10849	http://dx.doi.org/10.1002/ajmg.a.10849
DOI	10.1002/ajmg.a.33674	http://dx.doi.org/10.1002/ajmg.a.33674
DOI	10.1002/ajmg.a.36368	http://dx.doi.org/10.1002/ajmg.a.36368
DOI	10.1002/ajmg.a.36508	http://dx.doi.org/10.1002/ajmg.a.36508
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1021/bi981804i	http://dx.doi.org/10.1021/bi981804i
DOI	10.1034/j.1600-0625.2001.100409.x	http://dx.doi.org/10.1034/j.1600-0625.2001.100409.x
DOI	10.1038/10350	http://dx.doi.org/10.1038/10350
DOI	10.1038/10357	http://dx.doi.org/10.1038/10357
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1042/BJ20030465	http://dx.doi.org/10.1042/BJ20030465
DOI	10.1046/j.1432-1327.1999.00500.x	http://dx.doi.org/10.1046/j.1432-1327.1999.00500.x
DOI	10.1074/jbc.270.13.7551	http://dx.doi.org/10.1074/jbc.270.13.7551
DOI	10.1074/jbc.271.37.22434	http://dx.doi.org/10.1074/jbc.271.37.22434
DOI	10.1093/hmg/9.13.1951	http://dx.doi.org/10.1093/hmg/9.13.1951
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.2340/00015555-0337	http://dx.doi.org/10.2340/00015555-0337
DOI	10.4103/0019-5154.152570	http://dx.doi.org/10.4103/0019-5154.152570
DrugBank	DB00675	http://www.drugbank.ca/drugs/DB00675
EC_number	EC:5.3.3.5 {ECO:0000269|PubMed:12760743, ECO:0000269|PubMed:8798407, ECO:0000269|PubMed:9894009}	http://www.genome.jp/dbget-bin/www_bget?EC:5.3.3.5 {ECO:0000269|PubMed:12760743, ECO:0000269|PubMed:8798407, ECO:0000269|PubMed:9894009}
EMBL	AF196969	http://www.ebi.ac.uk/ena/data/view/AF196969
EMBL	AF196972	http://www.ebi.ac.uk/ena/data/view/AF196972
EMBL	BC001549	http://www.ebi.ac.uk/ena/data/view/BC001549
EMBL	BC001572	http://www.ebi.ac.uk/ena/data/view/BC001572
EMBL	BC046501	http://www.ebi.ac.uk/ena/data/view/BC046501
EMBL	CH471224	http://www.ebi.ac.uk/ena/data/view/CH471224
EMBL	CR456815	http://www.ebi.ac.uk/ena/data/view/CR456815
EMBL	CR542094	http://www.ebi.ac.uk/ena/data/view/CR542094
EMBL	Z37986	http://www.ebi.ac.uk/ena/data/view/Z37986
ENZYME	5.3.3.5 {ECO:0000269|PubMed:12760743, ECO:0000269|PubMed:8798407, ECO:0000269|PubMed:9894009}	http://enzyme.expasy.org/EC/5.3.3.5 {ECO:0000269|PubMed:12760743, ECO:0000269|PubMed:8798407, ECO:0000269|PubMed:9894009}
Ensembl	ENST00000495186	http://www.ensembl.org/id/ENST00000495186
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016023	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016023
GO_function	GO:0000247	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000247
GO_function	GO:0004769	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004769
GO_function	GO:0004888	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004888
GO_function	GO:0015238	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015238
GO_function	GO:0047750	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047750
GO_process	GO:0001501	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001501
GO_process	GO:0006695	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006695
GO_process	GO:0008203	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008203
GO_process	GO:0030097	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030097
GO_process	GO:0033489	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033489
GO_process	GO:0033490	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033490
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0016853	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GeneCards	EBP	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=EBP
GeneID	10682	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10682
GeneTree	ENSGT00530000063715	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063715
HGNC	HGNC:3133	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:3133
HOGENOM	HOG000204543	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000204543&db=HOGENOM6
HOVERGEN	HBG018176	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG018176&db=HOVERGEN
HPA	HPA003130	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA003130
InParanoid	Q15125	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q15125
IntAct	Q15125	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q15125*
IntEnz	5.3.3.5 {ECO:0000269|PubMed:12760743, ECO:0000269|PubMed:8798407, ECO:0000269|PubMed:9894009}	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.3.3.5 {ECO:0000269|PubMed:12760743, ECO:0000269|PubMed:8798407, ECO:0000269|PubMed:9894009}
InterPro	IPR007905	http://www.ebi.ac.uk/interpro/entry/IPR007905
InterPro	IPR033118	http://www.ebi.ac.uk/interpro/entry/IPR033118
Jabion	10682	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10682
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Disease	H01194	http://www.genome.jp/dbget-bin/www_bget?H01194
KEGG_Gene	hsa:10682	http://www.genome.jp/dbget-bin/www_bget?hsa:10682
KEGG_Orthology	KO:K01824	http://www.genome.jp/dbget-bin/www_bget?KO:K01824
KEGG_Pathway	ko00100	http://www.genome.jp/kegg-bin/show_pathway?ko00100
KEGG_Reaction	rn:R03353	http://www.genome.jp/dbget-bin/www_bget?rn:R03353
KEGG_Reaction	rn:R04804	http://www.genome.jp/dbget-bin/www_bget?rn:R04804
KEGG_Reaction	rn:R07484	http://www.genome.jp/dbget-bin/www_bget?rn:R07484
MIM	300205	http://www.ncbi.nlm.nih.gov/omim/300205
MIM	300960	http://www.ncbi.nlm.nih.gov/omim/300960
MIM	302960	http://www.ncbi.nlm.nih.gov/omim/302960
OMA	FVIHHET	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FVIHHET
Orphanet	35173	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=35173
Orphanet	352487	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=352487
Orphanet	401973	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=401973
OrthoDB	EOG091G0KCI	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0KCI
PANTHER	PTHR14207	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14207
PROSITE	PS51751	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51751
PSORT	swissprot:EBP_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:EBP_HUMAN
PSORT-B	swissprot:EBP_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:EBP_HUMAN
PSORT2	swissprot:EBP_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:EBP_HUMAN
Pfam	PF05241	http://pfam.xfam.org/family/PF05241
PharmGKB	PA27587	http://www.pharmgkb.org/do/serve?objId=PA27587&objCls=Gene
Phobius	swissprot:EBP_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:EBP_HUMAN
PhylomeDB	Q15125	http://phylomedb.org/?seqid=Q15125
ProteinModelPortal	Q15125	http://www.proteinmodelportal.org/query/uniprot/Q15125
PubMed	10391218	http://www.ncbi.nlm.nih.gov/pubmed/10391218
PubMed	10391219	http://www.ncbi.nlm.nih.gov/pubmed/10391219
PubMed	10406945	http://www.ncbi.nlm.nih.gov/pubmed/10406945
PubMed	10942423	http://www.ncbi.nlm.nih.gov/pubmed/10942423
PubMed	11493318	http://www.ncbi.nlm.nih.gov/pubmed/11493318
PubMed	12503101	http://www.ncbi.nlm.nih.gov/pubmed/12503101
PubMed	12760743	http://www.ncbi.nlm.nih.gov/pubmed/12760743
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	18176751	http://www.ncbi.nlm.nih.gov/pubmed/18176751
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	20949533	http://www.ncbi.nlm.nih.gov/pubmed/20949533
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	24459067	http://www.ncbi.nlm.nih.gov/pubmed/24459067
PubMed	24700572	http://www.ncbi.nlm.nih.gov/pubmed/24700572
PubMed	25814754	http://www.ncbi.nlm.nih.gov/pubmed/25814754
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	7706302	http://www.ncbi.nlm.nih.gov/pubmed/7706302
PubMed	8798407	http://www.ncbi.nlm.nih.gov/pubmed/8798407
PubMed	9894009	http://www.ncbi.nlm.nih.gov/pubmed/9894009
Reactome	R-HSA-6807047	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6807047
Reactome	R-HSA-6807062	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6807062
RefSeq	NP_006570	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006570
STRING	9606.ENSP00000417052	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000417052&targetmode=cogs
UCSC	uc004djx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004djx&org=rat
UniGene	Hs.30619	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.30619
UniProtKB	EBP_HUMAN	http://www.uniprot.org/uniprot/EBP_HUMAN
UniProtKB-AC	Q15125	http://www.uniprot.org/uniprot/Q15125
charge	swissprot:EBP_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:EBP_HUMAN
eggNOG	ENOG41101ES	http://eggnogapi.embl.de/nog_data/html/tree/ENOG41101ES
eggNOG	KOG4826	http://eggnogapi.embl.de/nog_data/html/tree/KOG4826
epestfind	swissprot:EBP_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:EBP_HUMAN
garnier	swissprot:EBP_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:EBP_HUMAN
helixturnhelix	swissprot:EBP_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:EBP_HUMAN
hmoment	swissprot:EBP_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:EBP_HUMAN
iep	swissprot:EBP_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:EBP_HUMAN
inforesidue	swissprot:EBP_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:EBP_HUMAN
neXtProt	NX_Q15125	http://www.nextprot.org/db/entry/NX_Q15125
octanol	swissprot:EBP_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:EBP_HUMAN
pepcoil	swissprot:EBP_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:EBP_HUMAN
pepdigest	swissprot:EBP_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:EBP_HUMAN
pepinfo	swissprot:EBP_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:EBP_HUMAN
pepnet	swissprot:EBP_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:EBP_HUMAN
pepstats	swissprot:EBP_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:EBP_HUMAN
pepwheel	swissprot:EBP_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:EBP_HUMAN
pepwindow	swissprot:EBP_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:EBP_HUMAN
sigcleave	swissprot:EBP_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:EBP_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	FAK2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14289-1; Sequence=Displayed; Name=2; Synonyms=PYK2H; IsoId=Q14289-2; Sequence=VSP_004981; 
# AltName	FAK2_HUMAN	Calcium-dependent tyrosine kinase
# AltName	FAK2_HUMAN	Calcium-regulated non-receptor proline-rich tyrosine kinase
# AltName	FAK2_HUMAN	Cell adhesion kinase beta
# AltName	FAK2_HUMAN	Focal adhesion kinase 2
# AltName	FAK2_HUMAN	Proline-rich tyrosine kinase 2
# AltName	FAK2_HUMAN	Related adhesion focal tyrosine kinase
# BRENDA	2.7.10	2681
# BioGrid	108480	60
# CATALYTIC ACTIVITY	FAK2_HUMAN	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. {ECO 0000255|PROSITE- ProRule PRU10028, ECO 0000269|PubMed 15050747, ECO 0000269|PubMed 15166227, ECO 0000269|PubMed 18339875, ECO 0000269|PubMed 18951788, ECO 0000269|PubMed 19428251, ECO 0000269|PubMed 19648005}. 
# CCDS	CCDS6057	-. [Q14289-1]
# CCDS	CCDS6058	-. [Q14289-2]
# ChiTaRS	PTK2B	human
# DISEASE	FAK2_HUMAN	Note=Aberrant PTK2B/PYK2 expression may play a role in cancer cell proliferation, migration and invasion, in tumor formation and metastasis. Elevated PTK2B/PYK2 expression is seen in gliomas, hepatocellular carcinoma, lung cancer and breast cancer. 
# DrugBank	DB01097	Leflunomide
# ENZYME REGULATION	FAK2_HUMAN	Activated in response to stimuli that lead to increased intracellular Ca(2+) levels; this activation is indirect and may be mediated by calcium-mediated production of reactive oxygen species (ROS). Activated by autophosphorylation at Tyr-402; this creates a binding site for SRC family kinases and leads to phosphorylation at additional tyrosine residues. Phosphorylation at Tyr-402, Tyr-579 and Tyr-580 is required for optimal kinase activity. Inhibited by PF-562,271, BIRB796, PF-4618433 and by PF- 431396, PF-2318841 and their derivatives. Inhibited by sulfoximine-substituted trifluoromethylpyrimidines. Inhibited by 4-amino and 5-aryl substituted pyridinone compounds. {ECO 0000269|PubMed 18339875, ECO 0000269|PubMed 18951788, ECO 0000269|PubMed 19428251, ECO 0000269|PubMed 19648005}. 
# Ensembl	ENST00000346049	ENSP00000332816; ENSG00000120899. [Q14289-1]
# Ensembl	ENST00000397501	ENSP00000380638; ENSG00000120899. [Q14289-1]
# Ensembl	ENST00000420218	ENSP00000391995; ENSG00000120899. [Q14289-2]
# Ensembl	ENST00000517339	ENSP00000427931; ENSG00000120899. [Q14289-2]
# ExpressionAtlas	Q14289	baseline and differential
# FUNCTION	FAK2_HUMAN	Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T- cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. {ECO 0000269|PubMed 10022920, ECO 0000269|PubMed 12771146, ECO 0000269|PubMed 12893833, ECO 0000269|PubMed 14585963, ECO 0000269|PubMed 15050747, ECO 0000269|PubMed 15166227, ECO 0000269|PubMed 17634955, ECO 0000269|PubMed 18086875, ECO 0000269|PubMed 18339875, ECO 0000269|PubMed 18587400, ECO 0000269|PubMed 18765415, ECO 0000269|PubMed 19086031, ECO 0000269|PubMed 19207108, ECO 0000269|PubMed 19244237, ECO 0000269|PubMed 19428251, ECO 0000269|PubMed 19648005, ECO 0000269|PubMed 19880522, ECO 0000269|PubMed 20001213, ECO 0000269|PubMed 20381867, ECO 0000269|PubMed 20521079, ECO 0000269|PubMed 21357692, ECO 0000269|PubMed 21533080, ECO 0000269|PubMed 7544443, ECO 0000269|PubMed 8670418, ECO 0000269|PubMed 8849729}. 
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005654	nucleoplasm; IDA:HPA.
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0005856	cytoskeleton; IEA:InterPro.
# GO_component	GO:0005925	focal adhesion; IDA:UniProtKB.
# GO_component	GO:0005938	cell cortex; IEA:UniProtKB-SubCell.
# GO_component	GO:0014069	postsynaptic density; ISS:Alzheimers_University_of_Toronto.
# GO_component	GO:0017146	NMDA selective glutamate receptor complex; ISS:Alzheimers_University_of_Toronto.
# GO_component	GO:0030027	lamellipodium; IDA:UniProtKB.
# GO_component	GO:0030424	axon; IEA:Ensembl.
# GO_component	GO:0030425	dendrite; ISS:Alzheimers_University_of_Toronto.
# GO_component	GO:0030426	growth cone; ISS:Alzheimers_University_of_Toronto.
# GO_component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane; IBA:GO_Central.
# GO_component	GO:0043025	neuronal cell body; ISS:Alzheimers_University_of_Toronto.
# GO_component	GO:0044297	cell body; ISS:Alzheimers_University_of_Toronto.
# GO_component	GO:0045121	membrane raft; IEA:Ensembl.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IDA:UniProtKB.
# GO_component	GO:0097440	apical dendrite; ISS:Alzheimers_University_of_Toronto.
# GO_function	GO:0004683	calmodulin-dependent protein kinase activity; ISS:Alzheimers_University_of_Toronto.
# GO_function	GO:0004713	protein tyrosine kinase activity; TAS:ProtInc.
# GO_function	GO:0004715	non-membrane spanning protein tyrosine kinase activity; IDA:UniProtKB.
# GO_function	GO:0004871	signal transducer activity; NAS:ProtInc.
# GO_function	GO:0004972	NMDA glutamate receptor activity; IEA:Ensembl.
# GO_function	GO:0005102	receptor binding; IBA:GO_Central.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_process	GO:0000165	MAPK cascade; IEA:Ensembl.
# GO_process	GO:0001525	angiogenesis; IBA:GO_Central.
# GO_process	GO:0001556	oocyte maturation; IEA:Ensembl.
# GO_process	GO:0001666	response to hypoxia; IEA:Ensembl.
# GO_process	GO:0001954	positive regulation of cell-matrix adhesion; IMP:UniProtKB.
# GO_process	GO:0002040	sprouting angiogenesis; ISS:UniProtKB.
# GO_process	GO:0002250	adaptive immune response; IEA:UniProtKB-KW.
# GO_process	GO:0002315	marginal zone B cell differentiation; ISS:UniProtKB.
# GO_process	GO:0006461	protein complex assembly; TAS:ProtInc.
# GO_process	GO:0006468	protein phosphorylation; TAS:ProtInc.
# GO_process	GO:0006915	apoptotic process; TAS:ProtInc.
# GO_process	GO:0006950	response to stress; TAS:ProtInc.
# GO_process	GO:0006968	cellular defense response; ISS:Alzheimers_University_of_Toronto.
# GO_process	GO:0006970	response to osmotic stress; IEA:Ensembl.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0007166	cell surface receptor signaling pathway; IMP:UniProtKB.
# GO_process	GO:0007172	signal complex assembly; TAS:ProtInc.
# GO_process	GO:0007173	epidermal growth factor receptor signaling pathway; IBA:GO_Central.
# GO_process	GO:0007204	positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
# GO_process	GO:0007229	integrin-mediated signaling pathway; IMP:UniProtKB.
# GO_process	GO:0008284	positive regulation of cell proliferation; IMP:UniProtKB.
# GO_process	GO:0008285	negative regulation of cell proliferation; IMP:UniProtKB.
# GO_process	GO:0008360	regulation of cell shape; IMP:UniProtKB.
# GO_process	GO:0009612	response to mechanical stimulus; IEA:Ensembl.
# GO_process	GO:0009725	response to hormone; IEA:Ensembl.
# GO_process	GO:0009749	response to glucose; IEA:Ensembl.
# GO_process	GO:0010226	response to lithium ion; IEA:Ensembl.
# GO_process	GO:0010595	positive regulation of endothelial cell migration; IDA:BHF-UCL.
# GO_process	GO:0010656	negative regulation of muscle cell apoptotic process; IEA:Ensembl.
# GO_process	GO:0010752	regulation of cGMP-mediated signaling; IEA:Ensembl.
# GO_process	GO:0010758	regulation of macrophage chemotaxis; ISS:UniProtKB.
# GO_process	GO:0010976	positive regulation of neuron projection development; IMP:BHF-UCL.
# GO_process	GO:0014009	glial cell proliferation; IEA:Ensembl.
# GO_process	GO:0018108	peptidyl-tyrosine phosphorylation; IDA:UniProtKB.
# GO_process	GO:0030155	regulation of cell adhesion; IMP:UniProtKB.
# GO_process	GO:0030307	positive regulation of cell growth; IEA:Ensembl.
# GO_process	GO:0030335	positive regulation of cell migration; IMP:UniProtKB.
# GO_process	GO:0030502	negative regulation of bone mineralization; ISS:UniProtKB.
# GO_process	GO:0030826	regulation of cGMP biosynthetic process; IEA:Ensembl.
# GO_process	GO:0030838	positive regulation of actin filament polymerization; IMP:UniProtKB.
# GO_process	GO:0031175	neuron projection development; IEA:Ensembl.
# GO_process	GO:0032960	regulation of inositol trisphosphate biosynthetic process; ISS:UniProtKB.
# GO_process	GO:0033209	tumor necrosis factor-mediated signaling pathway; IMP:UniProtKB.
# GO_process	GO:0035235	ionotropic glutamate receptor signaling pathway; ISS:Alzheimers_University_of_Toronto.
# GO_process	GO:0035902	response to immobilization stress; IEA:Ensembl.
# GO_process	GO:0038083	peptidyl-tyrosine autophosphorylation; IDA:BHF-UCL.
# GO_process	GO:0042220	response to cocaine; IEA:Ensembl.
# GO_process	GO:0042493	response to drug; IEA:Ensembl.
# GO_process	GO:0042542	response to hydrogen peroxide; IEA:Ensembl.
# GO_process	GO:0042976	activation of Janus kinase activity; IMP:UniProtKB.
# GO_process	GO:0043066	negative regulation of apoptotic process; IMP:UniProtKB.
# GO_process	GO:0043149	stress fiber assembly; IEA:Ensembl.
# GO_process	GO:0043267	negative regulation of potassium ion transport; IDA:UniProtKB.
# GO_process	GO:0043507	positive regulation of JUN kinase activity; IEA:Ensembl.
# GO_process	GO:0043524	negative regulation of neuron apoptotic process; ISS:Alzheimers_University_of_Toronto.
# GO_process	GO:0043534	blood vessel endothelial cell migration; IEA:Ensembl.
# GO_process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity; ISS:UniProtKB.
# GO_process	GO:0045087	innate immune response; IBA:GO_Central.
# GO_process	GO:0045429	positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
# GO_process	GO:0045453	bone resorption; ISS:UniProtKB.
# GO_process	GO:0045471	response to ethanol; IEA:Ensembl.
# GO_process	GO:0045638	negative regulation of myeloid cell differentiation; IMP:UniProtKB.
# GO_process	GO:0045727	positive regulation of translation; IEA:Ensembl.
# GO_process	GO:0045766	positive regulation of angiogenesis; IEA:Ensembl.
# GO_process	GO:0045860	positive regulation of protein kinase activity; IMP:UniProtKB.
# GO_process	GO:0046330	positive regulation of JNK cascade; IMP:UniProtKB.
# GO_process	GO:0046777	protein autophosphorylation; TAS:UniProtKB.
# GO_process	GO:0048010	vascular endothelial growth factor receptor signaling pathway; IMP:BHF-UCL.
# GO_process	GO:0048041	focal adhesion assembly; IEA:Ensembl.
# GO_process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation; IDA:BHF-UCL.
# GO_process	GO:0050848	regulation of calcium-mediated signaling; IEA:Ensembl.
# GO_process	GO:0051000	positive regulation of nitric-oxide synthase activity; IEA:Ensembl.
# GO_process	GO:0051279	regulation of release of sequestered calcium ion into cytosol; ISS:UniProtKB.
# GO_process	GO:0051591	response to cAMP; IEA:Ensembl.
# GO_process	GO:0051592	response to calcium ion; IEA:Ensembl.
# GO_process	GO:0051968	positive regulation of synaptic transmission, glutamatergic; ISS:Alzheimers_University_of_Toronto.
# GO_process	GO:0060291	long-term synaptic potentiation; ISS:Alzheimers_University_of_Toronto.
# GO_process	GO:0060292	long term synaptic depression; IEA:Ensembl.
# GO_process	GO:0070098	chemokine-mediated signaling pathway; ISS:UniProtKB.
# GO_process	GO:0070374	positive regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.
# GO_process	GO:0071300	cellular response to retinoic acid; IMP:BHF-UCL.
# GO_process	GO:0071498	cellular response to fluid shear stress; IEA:Ensembl.
# GO_process	GO:0090630	activation of GTPase activity; IEA:Ensembl.
# GO_process	GO:2000058	regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:UniProtKB.
# GO_process	GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Ensembl.
# GO_process	GO:2000114	regulation of establishment of cell polarity; ISS:UniProtKB.
# GO_process	GO:2000249	regulation of actin cytoskeleton reorganization; ISS:UniProtKB.
# GO_process	GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity; ISS:Alzheimers_University_of_Toronto.
# GO_process	GO:2000463	positive regulation of excitatory postsynaptic potential; ISS:Alzheimers_University_of_Toronto.
# GO_process	GO:2000538	positive regulation of B cell chemotaxis; ISS:UniProtKB.
# GO_process	GO:2000573	positive regulation of DNA biosynthetic process; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005856	cytoskeleton
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0016301	kinase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007010	cytoskeleton organization
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0008219	cell death
# GOslim_process	GO:0008283	cell proliferation
# GOslim_process	GO:0021700	developmental maturation
# GOslim_process	GO:0022607	cellular component assembly
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0034330	cell junction organization
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048646	anatomical structure formation involved in morphogenesis
# GOslim_process	GO:0048870	cell motility
# Gene3D	1.20.80.10	-; 1.
# Genevisible	Q14289	HS
# HGNC	HGNC:9612	PTK2B
# INTERACTION	FAK2_HUMAN	O75161 NPHP4; NbExp=2; IntAct=EBI-298640, EBI-4281852; Q7L0Q8 RHOU; NbExp=4; IntAct=EBI-298640, EBI-1638043; P12931 SRC; NbExp=3; IntAct=EBI-298640, EBI-621482; 
# IntAct	Q14289	15
# InterPro	IPR000299	FERM_domain
# InterPro	IPR000719	Prot_kinase_dom
# InterPro	IPR001245	Ser-Thr/Tyr_kinase_cat_dom
# InterPro	IPR005189	Focal_adhesion_kin_target_dom
# InterPro	IPR008266	Tyr_kinase_AS
# InterPro	IPR011009	Kinase-like_dom
# InterPro	IPR011993	PH_dom-like
# InterPro	IPR014352	FERM/acyl-CoA-bd_prot_3-hlx
# InterPro	IPR017441	Protein_kinase_ATP_BS
# InterPro	IPR019748	FERM_central
# InterPro	IPR019749	Band_41_domain
# InterPro	IPR020635	Tyr_kinase_cat_dom
# InterPro	IPR029071	Ubiquitin-rel_dom
# InterPro	IPR030610	PTK2B
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Brite	ko01001	 Protein kinases
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04062	Chemokine signaling pathway
# KEGG_Pathway	ko04650	Natural killer cell mediated cytotoxicity
# KEGG_Pathway	ko04670	Leukocyte transendothelial migration
# KEGG_Pathway	ko04912	GnRH signaling pathway
# KEGG_Pathway	ko05161	Hepatitis B
# MIM	601212	gene
# MISCELLANEOUS	FAK2_HUMAN	Promotes bone resorption, and thus PTK2B/PYK2 inhibitors might be used to treat osteoporosis. 
# Organism	FAK2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR24418:SF94	PTHR24418:SF94
# PDB	2FO6	Model; -; X=45-350
# PDB	2LK4	NMR; -; A=871-1005
# PDB	3CC6	X-ray; 1.60 A; A=414-692
# PDB	3ET7	X-ray; 2.70 A; A=416-692
# PDB	3FZO	X-ray; 2.20 A; A=416-692
# PDB	3FZP	X-ray; 2.10 A; A=416-692
# PDB	3FZR	X-ray; 2.70 A; A=416-692
# PDB	3FZS	X-ray; 1.75 A; A=416-692
# PDB	3FZT	X-ray; 1.95 A; A=416-692
# PDB	3GM1	X-ray; 2.95 A; A/B=861-1009
# PDB	3GM2	X-ray; 2.71 A; A=861-1009
# PDB	3GM3	X-ray; 2.60 A; A=861-1009
# PDB	3H3C	X-ray; 2.00 A; A=416-692
# PDB	3U3F	X-ray; 3.10 A; A/B/C/D=871-1005
# PDB	4EKU	X-ray; 3.25 A; A=21-409
# PDB	4H1J	X-ray; 2.00 A; A=416-692
# PDB	4H1M	X-ray; 1.99 A; A=416-692
# PDB	4R32	X-ray; 3.50 A; A=871-1005
# PDB	4XEF	X-ray; 2.50 A; A/D=871-1005
# PDB	4XEK	X-ray; 1.79 A; A=871-1005
# PDB	4XEV	X-ray; 2.01 A; A/D=871-1005
# PIR	S60248	S60248
# PRINTS	PR00109	TYRKINASE
# PROSITE	PS00107	PROTEIN_KINASE_ATP
# PROSITE	PS00109	PROTEIN_KINASE_TYR
# PROSITE	PS50011	PROTEIN_KINASE_DOM
# PROSITE	PS50057	FERM_3
# PTM	FAK2_HUMAN	Phosphorylated on tyrosine residues in response to various stimuli that elevate the intracellular calcium concentration; this activation is indirect and may be mediated by production of reactive oxygen species (ROS). Tyr-402 is the major autophosphorylation site, but other kinases can also phosphorylate Tyr-402. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-402 promotes interaction with SRC and SRC family members, leading to phosphorylation at Tyr-579; Tyr-580 and Tyr-881. Phosphorylation at Tyr-881 is important for interaction with GRB2. Phosphorylated on tyrosine residues upon activation of FGR and PKC. Recruitment by NPHP1 to cell matrix adhesions initiates Tyr-402 phosphorylation. In monocytes, adherence to substrata is required for tyrosine phosphorylation and kinase activation. Angiotensin II, thapsigargin and L-alpha- lysophosphatidic acid (LPA) also induce autophosphorylation and increase kinase activity. Phosphorylation by MYLK promotes ITGB2 activation and is thus essential to trigger neutrophil transmigration during lung injury. Dephosphorylated by PTPN12. {ECO 0000269|PubMed 11493697, ECO 0000269|PubMed 15166227, ECO 0000269|PubMed 17329398, ECO 0000269|PubMed 18587400, ECO 0000269|PubMed 19207108, ECO 0000269|PubMed 20028775, ECO 0000269|PubMed 20381867, ECO 0000269|PubMed 20521079, ECO 0000269|PubMed 9545257}. 
# Pfam	PF00373	FERM_M
# Pfam	PF03623	Focal_AT
# Pfam	PF07714	Pkinase_Tyr
# ProDom	PD006413	Focal_adhesion_target_reg
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-391160	Signal regulatory protein (SIRP) family interactions
# Reactome	R-HSA-4420097	VEGFA-VEGFR2 Pathway
# Reactome	R-HSA-451927	Interleukin-2 signaling
# RecName	FAK2_HUMAN	Protein-tyrosine kinase 2-beta
# RefSeq	NP_004094	NM_004103.4. [Q14289-1]
# RefSeq	NP_775266	NM_173174.2. [Q14289-1]
# RefSeq	NP_775267	NM_173175.2. [Q14289-2]
# RefSeq	NP_775268	NM_173176.2. [Q14289-1]
# RefSeq	XP_005273504	XM_005273447.4. [Q14289-1]
# RefSeq	XP_011542743	XM_011544441.2. [Q14289-1]
# RefSeq	XP_016868703	XM_017013214.1. [Q14289-1]
# SIMILARITY	Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily. {ECO:0000255|PROSITE- ProRule	PRU00159}. 
# SIMILARITY	Contains 1 FERM domain. {ECO:0000255|PROSITE- ProRule	PRU00084}. 
# SIMILARITY	Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule	PRU00159}.
# SMART	SM00219	TyrKc
# SMART	SM00295	B41
# SUBCELLULAR LOCATION	FAK2_HUMAN	Cytoplasm. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, focal adhesion. Cell projection, lamellipodium. Cytoplasm, cell cortex. Nucleus. Note=Interaction with NPHP1 induces the membrane-association of the kinase. Colocalizes with integrins at the cell periphery. 
# SUBUNIT	FAK2_HUMAN	Homodimer, or homooligomer. Interacts with SIRPA and SH2D3C. Interacts with ARHGAP10. Interacts with DLG4 (By similarity). Interacts with KCNA2 (By similarity). Interacts with NPHP1, ASAP1, ASAP2, ARHGAP26, SKAP2 and TGFB1I1. The Tyr-402 phosphorylated form interacts with SRC (via SH2 domain) and SRC family members. Forms a signaling complex with EPHA1, LCK and phosphatidylinositol 3-kinase; upon activation by EFNA1. Interacts with GRB2 (via SH2 domain). Interacts with P53/TP53 and MDM2. Interacts with MYLK. Interacts with BCAR1. Interacts with PDPK1. Interacts (hypophosphorylated) with PXN. Interacts with RB1CC1. Interacts with RHOU. Interacts with VAV1. Interacts with LPXN and PTPN12. {ECO 0000250|UniProtKB P70600, ECO 0000250|UniProtKB Q9QVP9, ECO 0000269|PubMed 10022920, ECO 0000269|PubMed 10769033, ECO 0000269|PubMed 11493697, ECO 0000269|PubMed 12771146, ECO 0000269|PubMed 12893833, ECO 0000269|PubMed 14585963, ECO 0000269|PubMed 17329398, ECO 0000269|PubMed 17634955, ECO 0000269|PubMed 18086875, ECO 0000269|PubMed 18587400, ECO 0000269|PubMed 18765415, ECO 0000269|PubMed 18951788, ECO 0000269|PubMed 19086031, ECO 0000269|PubMed 19207108, ECO 0000269|PubMed 19358827, ECO 0000269|PubMed 19428251, ECO 0000269|PubMed 20521079, ECO 0000269|PubMed 21357692, ECO 0000269|PubMed 7544443, ECO 0000269|PubMed 8849729, ECO 0000269|PubMed 9422762}. 
# SUPFAM	SSF47031	SSF47031
# SUPFAM	SSF50729	SSF50729
# SUPFAM	SSF54236	SSF54236
# SUPFAM	SSF56112	SSF56112
# SUPFAM	SSF68993	SSF68993
# TISSUE SPECIFICITY	FAK2_HUMAN	Most abundant in the brain, with highest levels in amygdala and hippocampus. Low levels in kidney (at protein level). Also expressed in spleen and lymphocytes. {ECO 0000269|PubMed 7544443, ECO 0000269|PubMed 9545257}. 
# TopDownProteomics	Q14289-2	-. [Q14289-2]
# UCSC	uc003xfn	human. [Q14289-1]
# eggNOG	ENOG410ZH9Y	LUCA
# eggNOG	KOG4257	Eukaryota
BLAST	swissprot:FAK2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:FAK2_HUMAN
BioCyc	ZFISH:HS04447-MONOMER	http://biocyc.org/getid?id=ZFISH:HS04447-MONOMER
COXPRESdb	2185	http://coxpresdb.jp/data/gene/2185.shtml
CleanEx	HS_PTK2B	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_PTK2B
DOI	10.1002/eji.200737111	http://dx.doi.org/10.1002/eji.200737111
DOI	10.1002/jcp.21649	http://dx.doi.org/10.1002/jcp.21649
DOI	10.1006/geno.1996.0149	http://dx.doi.org/10.1006/geno.1996.0149
DOI	10.1007/s00018-010-0411-x	http://dx.doi.org/10.1007/s00018-010-0411-x
DOI	10.1016/j.bbrc.2009.04.011	http://dx.doi.org/10.1016/j.bbrc.2009.04.011
DOI	10.1016/j.bmcl.2008.10.030	http://dx.doi.org/10.1016/j.bmcl.2008.10.030
DOI	10.1016/j.bmcl.2009.04.093	http://dx.doi.org/10.1016/j.bmcl.2009.04.093
DOI	10.1016/j.bmcl.2009.07.084	http://dx.doi.org/10.1016/j.bmcl.2009.07.084
DOI	10.1016/j.exphem.2004.01.001	http://dx.doi.org/10.1016/j.exphem.2004.01.001
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1016/j.molimm.2010.03.009	http://dx.doi.org/10.1016/j.molimm.2010.03.009
DOI	10.1021/pr0704130	http://dx.doi.org/10.1021/pr0704130
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/376737a0	http://dx.doi.org/10.1038/376737a0
DOI	10.1038/383547a0	http://dx.doi.org/10.1038/383547a0
DOI	10.1038/nature04406	http://dx.doi.org/10.1038/nature04406
DOI	10.1038/nature05610	http://dx.doi.org/10.1038/nature05610
DOI	10.1038/ni.1628	http://dx.doi.org/10.1038/ni.1628
DOI	10.1042/BJ20090037	http://dx.doi.org/10.1042/BJ20090037
DOI	10.1073/pnas.171269898	http://dx.doi.org/10.1073/pnas.171269898
DOI	10.1073/pnas.2436191100	http://dx.doi.org/10.1073/pnas.2436191100
DOI	10.1074/jbc.270.36.21206	http://dx.doi.org/10.1074/jbc.270.36.21206
DOI	10.1074/jbc.270.46.27742	http://dx.doi.org/10.1074/jbc.270.46.27742
DOI	10.1074/jbc.273.16.9361	http://dx.doi.org/10.1074/jbc.273.16.9361
DOI	10.1074/jbc.273.2.1003	http://dx.doi.org/10.1074/jbc.273.2.1003
DOI	10.1074/jbc.M109.064212	http://dx.doi.org/10.1074/jbc.M109.064212
DOI	10.1074/jbc.M110.165464	http://dx.doi.org/10.1074/jbc.M110.165464
DOI	10.1074/jbc.M213217200	http://dx.doi.org/10.1074/jbc.M213217200
DOI	10.1074/jbc.M302278200	http://dx.doi.org/10.1074/jbc.M302278200
DOI	10.1074/jbc.M313527200	http://dx.doi.org/10.1074/jbc.M313527200
DOI	10.1074/jbc.M809038200	http://dx.doi.org/10.1074/jbc.M809038200
DOI	10.1074/mcp.M800588-MCP200	http://dx.doi.org/10.1074/mcp.M800588-MCP200
DOI	10.1083/jcb.149.2.423	http://dx.doi.org/10.1083/jcb.149.2.423
DOI	10.1093/carcin/bgn203	http://dx.doi.org/10.1093/carcin/bgn203
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.273.5276.792	http://dx.doi.org/10.1126/science.273.5276.792
DOI	10.1128/MCB.00201-07	http://dx.doi.org/10.1128/MCB.00201-07
DOI	10.1128/MCB.19.3.2338	http://dx.doi.org/10.1128/MCB.19.3.2338
DOI	10.1128/MCB.23.22.8019-8029.2003	http://dx.doi.org/10.1128/MCB.23.22.8019-8029.2003
DOI	10.1152/ajpcell.00503.2006	http://dx.doi.org/10.1152/ajpcell.00503.2006
DOI	10.1158/0008-5472.CAN-07-5155	http://dx.doi.org/10.1158/0008-5472.CAN-07-5155
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1189/jlb.0409227	http://dx.doi.org/10.1189/jlb.0409227
DOI	10.1242/jcs.045112	http://dx.doi.org/10.1242/jcs.045112
DOI	10.1371/journal.pone.0018878	http://dx.doi.org/10.1371/journal.pone.0018878
DOI	10.1385/IR:31:3:267	http://dx.doi.org/10.1385/IR:31:3:267
DOI	10.1517/14728220903473194	http://dx.doi.org/10.1517/14728220903473194
DOI	10.2741/3706	http://dx.doi.org/10.2741/3706
DrugBank	DB01097	http://www.drugbank.ca/drugs/DB01097
EC_number	EC:2.7.10.2	http://www.genome.jp/dbget-bin/www_bget?EC:2.7.10.2
EMBL	AF311103	http://www.ebi.ac.uk/ena/data/view/AF311103
EMBL	BC036651	http://www.ebi.ac.uk/ena/data/view/BC036651
EMBL	BC042599	http://www.ebi.ac.uk/ena/data/view/BC042599
EMBL	CH471080	http://www.ebi.ac.uk/ena/data/view/CH471080
EMBL	CH471080	http://www.ebi.ac.uk/ena/data/view/CH471080
EMBL	CH471080	http://www.ebi.ac.uk/ena/data/view/CH471080
EMBL	D45853	http://www.ebi.ac.uk/ena/data/view/D45853
EMBL	L49207	http://www.ebi.ac.uk/ena/data/view/L49207
EMBL	S80542	http://www.ebi.ac.uk/ena/data/view/S80542
EMBL	U33284	http://www.ebi.ac.uk/ena/data/view/U33284
EMBL	U43522	http://www.ebi.ac.uk/ena/data/view/U43522
ENZYME	2.7.10.2	http://enzyme.expasy.org/EC/2.7.10.2
Ensembl	ENST00000346049	http://www.ensembl.org/id/ENST00000346049
Ensembl	ENST00000397501	http://www.ensembl.org/id/ENST00000397501
Ensembl	ENST00000420218	http://www.ensembl.org/id/ENST00000420218
Ensembl	ENST00000517339	http://www.ensembl.org/id/ENST00000517339
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856
GO_component	GO:0005925	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005925
GO_component	GO:0005938	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005938
GO_component	GO:0014069	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014069
GO_component	GO:0017146	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017146
GO_component	GO:0030027	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030027
GO_component	GO:0030424	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030424
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0030426	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030426
GO_component	GO:0031234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031234
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0044297	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044297
GO_component	GO:0045121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045121
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_component	GO:0097440	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097440
GO_function	GO:0004683	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004683
GO_function	GO:0004713	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004713
GO_function	GO:0004715	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004715
GO_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GO_function	GO:0004972	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004972
GO_function	GO:0005102	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005102
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_process	GO:0000165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000165
GO_process	GO:0001525	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001525
GO_process	GO:0001556	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001556
GO_process	GO:0001666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001666
GO_process	GO:0001954	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001954
GO_process	GO:0002040	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002040
GO_process	GO:0002250	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002250
GO_process	GO:0002315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002315
GO_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GO_process	GO:0006468	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006468
GO_process	GO:0006915	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006915
GO_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GO_process	GO:0006968	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006968
GO_process	GO:0006970	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006970
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007166	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007166
GO_process	GO:0007172	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007172
GO_process	GO:0007173	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007173
GO_process	GO:0007204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007204
GO_process	GO:0007229	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007229
GO_process	GO:0008284	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008284
GO_process	GO:0008285	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008285
GO_process	GO:0008360	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360
GO_process	GO:0009612	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009612
GO_process	GO:0009725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009725
GO_process	GO:0009749	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009749
GO_process	GO:0010226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010226
GO_process	GO:0010595	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010595
GO_process	GO:0010656	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010656
GO_process	GO:0010752	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010752
GO_process	GO:0010758	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010758
GO_process	GO:0010976	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010976
GO_process	GO:0014009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014009
GO_process	GO:0018108	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018108
GO_process	GO:0030155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030155
GO_process	GO:0030307	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030307
GO_process	GO:0030335	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030335
GO_process	GO:0030502	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030502
GO_process	GO:0030826	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030826
GO_process	GO:0030838	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030838
GO_process	GO:0031175	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031175
GO_process	GO:0032960	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032960
GO_process	GO:0033209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033209
GO_process	GO:0035235	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035235
GO_process	GO:0035902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035902
GO_process	GO:0038083	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0038083
GO_process	GO:0042220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042220
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0042542	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042542
GO_process	GO:0042976	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042976
GO_process	GO:0043066	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043066
GO_process	GO:0043149	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043149
GO_process	GO:0043267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043267
GO_process	GO:0043507	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043507
GO_process	GO:0043524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043524
GO_process	GO:0043534	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043534
GO_process	GO:0043552	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043552
GO_process	GO:0045087	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045087
GO_process	GO:0045429	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045429
GO_process	GO:0045453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045453
GO_process	GO:0045471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045471
GO_process	GO:0045638	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045638
GO_process	GO:0045727	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045727
GO_process	GO:0045766	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045766
GO_process	GO:0045860	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045860
GO_process	GO:0046330	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046330
GO_process	GO:0046777	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046777
GO_process	GO:0048010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048010
GO_process	GO:0048041	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048041
GO_process	GO:0050731	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050731
GO_process	GO:0050848	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050848
GO_process	GO:0051000	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051000
GO_process	GO:0051279	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051279
GO_process	GO:0051591	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051591
GO_process	GO:0051592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051592
GO_process	GO:0051968	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051968
GO_process	GO:0060291	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060291
GO_process	GO:0060292	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060292
GO_process	GO:0070098	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070098
GO_process	GO:0070374	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070374
GO_process	GO:0071300	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071300
GO_process	GO:0071498	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071498
GO_process	GO:0090630	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090630
GO_process	GO:2000058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000058
GO_process	GO:2000060	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000060
GO_process	GO:2000114	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000114
GO_process	GO:2000249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000249
GO_process	GO:2000310	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000310
GO_process	GO:2000463	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000463
GO_process	GO:2000538	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000538
GO_process	GO:2000573	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000573
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0016301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007010
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0008219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219
GOslim_process	GO:0008283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008283
GOslim_process	GO:0021700	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021700
GOslim_process	GO:0022607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0034330	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034330
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048646	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048646
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
Gene3D	1.20.80.10	http://www.cathdb.info/version/latest/superfamily/1.20.80.10
GeneCards	PTK2B	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=PTK2B
GeneID	2185	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2185
GeneTree	ENSGT00760000118799	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118799
H-InvDB	HIX0168898	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0168898
HGNC	HGNC:9612	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:9612
HOGENOM	HOG000069938	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000069938&db=HOGENOM6
HOVERGEN	HBG004018	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004018&db=HOVERGEN
HPA	CAB003850	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB003850
HPA	HPA026091	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA026091
HPA	HPA026276	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA026276
InParanoid	Q14289	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q14289
IntAct	Q14289	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q14289*
IntEnz	2.7.10.2	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.10.2
InterPro	IPR000299	http://www.ebi.ac.uk/interpro/entry/IPR000299
InterPro	IPR000719	http://www.ebi.ac.uk/interpro/entry/IPR000719
InterPro	IPR001245	http://www.ebi.ac.uk/interpro/entry/IPR001245
InterPro	IPR005189	http://www.ebi.ac.uk/interpro/entry/IPR005189
InterPro	IPR008266	http://www.ebi.ac.uk/interpro/entry/IPR008266
InterPro	IPR011009	http://www.ebi.ac.uk/interpro/entry/IPR011009
InterPro	IPR011993	http://www.ebi.ac.uk/interpro/entry/IPR011993
InterPro	IPR014352	http://www.ebi.ac.uk/interpro/entry/IPR014352
InterPro	IPR017441	http://www.ebi.ac.uk/interpro/entry/IPR017441
InterPro	IPR019748	http://www.ebi.ac.uk/interpro/entry/IPR019748
InterPro	IPR019749	http://www.ebi.ac.uk/interpro/entry/IPR019749
InterPro	IPR020635	http://www.ebi.ac.uk/interpro/entry/IPR020635
InterPro	IPR029071	http://www.ebi.ac.uk/interpro/entry/IPR029071
InterPro	IPR030610	http://www.ebi.ac.uk/interpro/entry/IPR030610
Jabion	2185	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2185
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Brite	ko01001	http://www.genome.jp/dbget-bin/www_bget?ko01001
KEGG_Gene	hsa:2185	http://www.genome.jp/dbget-bin/www_bget?hsa:2185
KEGG_Orthology	KO:K05871	http://www.genome.jp/dbget-bin/www_bget?KO:K05871
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04062	http://www.genome.jp/kegg-bin/show_pathway?ko04062
KEGG_Pathway	ko04650	http://www.genome.jp/kegg-bin/show_pathway?ko04650
KEGG_Pathway	ko04670	http://www.genome.jp/kegg-bin/show_pathway?ko04670
KEGG_Pathway	ko04912	http://www.genome.jp/kegg-bin/show_pathway?ko04912
KEGG_Pathway	ko05161	http://www.genome.jp/kegg-bin/show_pathway?ko05161
MIM	601212	http://www.ncbi.nlm.nih.gov/omim/601212
MINT	MINT-1211326	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1211326
OMA	VKTCKKD	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VKTCKKD
OrthoDB	EOG091G03BN	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G03BN
PANTHER	PTHR24418:SF94	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24418:SF94
PDB	2FO6	http://www.ebi.ac.uk/pdbe-srv/view/entry/2FO6
PDB	2LK4	http://www.ebi.ac.uk/pdbe-srv/view/entry/2LK4
PDB	3CC6	http://www.ebi.ac.uk/pdbe-srv/view/entry/3CC6
PDB	3ET7	http://www.ebi.ac.uk/pdbe-srv/view/entry/3ET7
PDB	3FZO	http://www.ebi.ac.uk/pdbe-srv/view/entry/3FZO
PDB	3FZP	http://www.ebi.ac.uk/pdbe-srv/view/entry/3FZP
PDB	3FZR	http://www.ebi.ac.uk/pdbe-srv/view/entry/3FZR
PDB	3FZS	http://www.ebi.ac.uk/pdbe-srv/view/entry/3FZS
PDB	3FZT	http://www.ebi.ac.uk/pdbe-srv/view/entry/3FZT
PDB	3GM1	http://www.ebi.ac.uk/pdbe-srv/view/entry/3GM1
PDB	3GM2	http://www.ebi.ac.uk/pdbe-srv/view/entry/3GM2
PDB	3GM3	http://www.ebi.ac.uk/pdbe-srv/view/entry/3GM3
PDB	3H3C	http://www.ebi.ac.uk/pdbe-srv/view/entry/3H3C
PDB	3U3F	http://www.ebi.ac.uk/pdbe-srv/view/entry/3U3F
PDB	4EKU	http://www.ebi.ac.uk/pdbe-srv/view/entry/4EKU
PDB	4H1J	http://www.ebi.ac.uk/pdbe-srv/view/entry/4H1J
PDB	4H1M	http://www.ebi.ac.uk/pdbe-srv/view/entry/4H1M
PDB	4R32	http://www.ebi.ac.uk/pdbe-srv/view/entry/4R32
PDB	4XEF	http://www.ebi.ac.uk/pdbe-srv/view/entry/4XEF
PDB	4XEK	http://www.ebi.ac.uk/pdbe-srv/view/entry/4XEK
PDB	4XEV	http://www.ebi.ac.uk/pdbe-srv/view/entry/4XEV
PDBsum	2FO6	http://www.ebi.ac.uk/pdbsum/2FO6
PDBsum	2LK4	http://www.ebi.ac.uk/pdbsum/2LK4
PDBsum	3CC6	http://www.ebi.ac.uk/pdbsum/3CC6
PDBsum	3ET7	http://www.ebi.ac.uk/pdbsum/3ET7
PDBsum	3FZO	http://www.ebi.ac.uk/pdbsum/3FZO
PDBsum	3FZP	http://www.ebi.ac.uk/pdbsum/3FZP
PDBsum	3FZR	http://www.ebi.ac.uk/pdbsum/3FZR
PDBsum	3FZS	http://www.ebi.ac.uk/pdbsum/3FZS
PDBsum	3FZT	http://www.ebi.ac.uk/pdbsum/3FZT
PDBsum	3GM1	http://www.ebi.ac.uk/pdbsum/3GM1
PDBsum	3GM2	http://www.ebi.ac.uk/pdbsum/3GM2
PDBsum	3GM3	http://www.ebi.ac.uk/pdbsum/3GM3
PDBsum	3H3C	http://www.ebi.ac.uk/pdbsum/3H3C
PDBsum	3U3F	http://www.ebi.ac.uk/pdbsum/3U3F
PDBsum	4EKU	http://www.ebi.ac.uk/pdbsum/4EKU
PDBsum	4H1J	http://www.ebi.ac.uk/pdbsum/4H1J
PDBsum	4H1M	http://www.ebi.ac.uk/pdbsum/4H1M
PDBsum	4R32	http://www.ebi.ac.uk/pdbsum/4R32
PDBsum	4XEF	http://www.ebi.ac.uk/pdbsum/4XEF
PDBsum	4XEK	http://www.ebi.ac.uk/pdbsum/4XEK
PDBsum	4XEV	http://www.ebi.ac.uk/pdbsum/4XEV
PRINTS	PR00109	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00109
PROSITE	PS00107	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00107
PROSITE	PS00109	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00109
PROSITE	PS50011	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50011
PROSITE	PS50057	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50057
PSORT	swissprot:FAK2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:FAK2_HUMAN
PSORT-B	swissprot:FAK2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:FAK2_HUMAN
PSORT2	swissprot:FAK2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:FAK2_HUMAN
Pfam	PF00373	http://pfam.xfam.org/family/PF00373
Pfam	PF03623	http://pfam.xfam.org/family/PF03623
Pfam	PF07714	http://pfam.xfam.org/family/PF07714
PharmGKB	PA33956	http://www.pharmgkb.org/do/serve?objId=PA33956&objCls=Gene
Phobius	swissprot:FAK2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:FAK2_HUMAN
PhylomeDB	Q14289	http://phylomedb.org/?seqid=Q14289
ProteinModelPortal	Q14289	http://www.proteinmodelportal.org/query/uniprot/Q14289
PubMed	10022920	http://www.ncbi.nlm.nih.gov/pubmed/10022920
PubMed	10769033	http://www.ncbi.nlm.nih.gov/pubmed/10769033
PubMed	11493697	http://www.ncbi.nlm.nih.gov/pubmed/11493697
PubMed	12522270	http://www.ncbi.nlm.nih.gov/pubmed/12522270
PubMed	12771146	http://www.ncbi.nlm.nih.gov/pubmed/12771146
PubMed	12893833	http://www.ncbi.nlm.nih.gov/pubmed/12893833
PubMed	14585963	http://www.ncbi.nlm.nih.gov/pubmed/14585963
PubMed	15050747	http://www.ncbi.nlm.nih.gov/pubmed/15050747
PubMed	15166227	http://www.ncbi.nlm.nih.gov/pubmed/15166227
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15888917	http://www.ncbi.nlm.nih.gov/pubmed/15888917
PubMed	16421571	http://www.ncbi.nlm.nih.gov/pubmed/16421571
PubMed	17329398	http://www.ncbi.nlm.nih.gov/pubmed/17329398
PubMed	17344846	http://www.ncbi.nlm.nih.gov/pubmed/17344846
PubMed	17634955	http://www.ncbi.nlm.nih.gov/pubmed/17634955
PubMed	18086875	http://www.ncbi.nlm.nih.gov/pubmed/18086875
PubMed	18088087	http://www.ncbi.nlm.nih.gov/pubmed/18088087
PubMed	18339875	http://www.ncbi.nlm.nih.gov/pubmed/18339875
PubMed	18587400	http://www.ncbi.nlm.nih.gov/pubmed/18587400
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	18765415	http://www.ncbi.nlm.nih.gov/pubmed/18765415
PubMed	18951788	http://www.ncbi.nlm.nih.gov/pubmed/18951788
PubMed	19086031	http://www.ncbi.nlm.nih.gov/pubmed/19086031
PubMed	19207108	http://www.ncbi.nlm.nih.gov/pubmed/19207108
PubMed	19244237	http://www.ncbi.nlm.nih.gov/pubmed/19244237
PubMed	19358827	http://www.ncbi.nlm.nih.gov/pubmed/19358827
PubMed	19369195	http://www.ncbi.nlm.nih.gov/pubmed/19369195
PubMed	19428251	http://www.ncbi.nlm.nih.gov/pubmed/19428251
PubMed	19648005	http://www.ncbi.nlm.nih.gov/pubmed/19648005
PubMed	19880522	http://www.ncbi.nlm.nih.gov/pubmed/19880522
PubMed	20001213	http://www.ncbi.nlm.nih.gov/pubmed/20001213
PubMed	20028775	http://www.ncbi.nlm.nih.gov/pubmed/20028775
PubMed	20332118	http://www.ncbi.nlm.nih.gov/pubmed/20332118
PubMed	20381867	http://www.ncbi.nlm.nih.gov/pubmed/20381867
PubMed	20521079	http://www.ncbi.nlm.nih.gov/pubmed/20521079
PubMed	21196189	http://www.ncbi.nlm.nih.gov/pubmed/21196189
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21357692	http://www.ncbi.nlm.nih.gov/pubmed/21357692
PubMed	21533080	http://www.ncbi.nlm.nih.gov/pubmed/21533080
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	7499242	http://www.ncbi.nlm.nih.gov/pubmed/7499242
PubMed	7544443	http://www.ncbi.nlm.nih.gov/pubmed/7544443
PubMed	7673154	http://www.ncbi.nlm.nih.gov/pubmed/7673154
PubMed	8670418	http://www.ncbi.nlm.nih.gov/pubmed/8670418
PubMed	8838818	http://www.ncbi.nlm.nih.gov/pubmed/8838818
PubMed	8849729	http://www.ncbi.nlm.nih.gov/pubmed/8849729
PubMed	9422762	http://www.ncbi.nlm.nih.gov/pubmed/9422762
PubMed	9545257	http://www.ncbi.nlm.nih.gov/pubmed/9545257
Reactome	R-HSA-391160	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-391160
Reactome	R-HSA-4420097	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-4420097
Reactome	R-HSA-451927	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-451927
RefSeq	NP_004094	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004094
RefSeq	NP_775266	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_775266
RefSeq	NP_775267	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_775267
RefSeq	NP_775268	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_775268
RefSeq	XP_005273504	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005273504
RefSeq	XP_011542743	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011542743
RefSeq	XP_016868703	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016868703
SMART	SM00219	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00219
SMART	SM00295	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00295
SMR	Q14289	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q14289
STRING	9606.ENSP00000332816	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000332816&targetmode=cogs
SUPFAM	SSF47031	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47031
SUPFAM	SSF50729	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50729
SUPFAM	SSF54236	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54236
SUPFAM	SSF56112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56112
SUPFAM	SSF68993	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF68993
UCSC	uc003xfn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003xfn&org=rat
UniGene	Hs.491322	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.491322
UniGene	Hs.735450	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.735450
UniProtKB	FAK2_HUMAN	http://www.uniprot.org/uniprot/FAK2_HUMAN
UniProtKB-AC	Q14289	http://www.uniprot.org/uniprot/Q14289
charge	swissprot:FAK2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:FAK2_HUMAN
eggNOG	ENOG410ZH9Y	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZH9Y
eggNOG	KOG4257	http://eggnogapi.embl.de/nog_data/html/tree/KOG4257
epestfind	swissprot:FAK2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:FAK2_HUMAN
garnier	swissprot:FAK2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:FAK2_HUMAN
helixturnhelix	swissprot:FAK2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:FAK2_HUMAN
hmoment	swissprot:FAK2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:FAK2_HUMAN
iep	swissprot:FAK2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:FAK2_HUMAN
inforesidue	swissprot:FAK2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:FAK2_HUMAN
neXtProt	NX_Q14289	http://www.nextprot.org/db/entry/NX_Q14289
octanol	swissprot:FAK2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:FAK2_HUMAN
pepcoil	swissprot:FAK2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:FAK2_HUMAN
pepdigest	swissprot:FAK2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:FAK2_HUMAN
pepinfo	swissprot:FAK2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:FAK2_HUMAN
pepnet	swissprot:FAK2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:FAK2_HUMAN
pepstats	swissprot:FAK2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:FAK2_HUMAN
pepwheel	swissprot:FAK2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:FAK2_HUMAN
pepwindow	swissprot:FAK2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:FAK2_HUMAN
sigcleave	swissprot:FAK2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:FAK2_HUMAN
## Database	ID	URL or Descriptions
# AltName	S22A4_HUMAN	Ergothioneine transporter
# AltName	S22A4_HUMAN	Organic cation/carnitine transporter 1
# BIOPHYSICOCHEMICAL PROPERTIES	S22A4_HUMAN	Kinetic parameters  KM=0.470 mM for TEA (at 37 degrees Celsius and pH 7.4) {ECO 0000269|PubMed 15459889, ECO 0000269|PubMed 9426230}; Vmax=0.974 nmol/min/mg enzyme toward TEA (at 37 degrees Celsius and pH 7.4) {ECO 0000269|PubMed 15459889, ECO 0000269|PubMed 9426230}; pH dependence  More active at neutral and alkaline pHs than at acidic pHs. {ECO 0000269|PubMed 15459889, ECO 0000269|PubMed 9426230}; 
# CAUTION	PubMed:9426230 reported that this protein does not transport carnitine, however, experiments were done with the Phe- 503 variant, which affects the ability to transport carnitine. PubMed	15459889 showed that, although weakly, it can also transport carnitine at some level. Its function in carnitine transport is therefore unclear. {ECO:0000305}.
# CDD	cd06174	MFS
# DISEASE	S22A4_HUMAN	Rheumatoid arthritis (RA) [MIM 180300]  An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. {ECO 0000269|PubMed 14608356}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# DrugBank	DB00122	Choline
# DrugBank	DB00123	L-Lysine
# DrugBank	DB00125	L-Arginine
# DrugBank	DB00127	Spermine
# DrugBank	DB00184	Nicotine
# DrugBank	DB00332	Ipratropium bromide
# DrugBank	DB00345	Aminohippurate
# DrugBank	DB00458	Imipramine
# DrugBank	DB00468	Quinine
# DrugBank	DB00501	Cimetidine
# DrugBank	DB00536	Guanidine
# DrugBank	DB00575	Clonidine
# DrugBank	DB00583	L-Carnitine
# DrugBank	DB00594	Amiloride
# DrugBank	DB00624	Testosterone
# DrugBank	DB00661	Verapamil
# DrugBank	DB00908	Quinidine
# DrugBank	DB01035	Procainamide
# DrugBank	DB01053	Benzylpenicillin
# DrugBank	DB01137	Levofloxacin
# DrugBank	DB01151	Desipramine
# DrugBank	DB01165	Ofloxacin
# DrugBank	DB01409	Tiotropium
# DrugBank	DB06691	Mepyramine
# Ensembl	ENST00000200652	ENSP00000200652; ENSG00000197208
# FUNCTION	S22A4_HUMAN	Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET). {ECO 0000269|PubMed 10215651, ECO 0000269|PubMed 15795384}. 
# GO_component	GO:0005739	mitochondrion; IDA:MGI.
# GO_component	GO:0005886	plasma membrane; IC:BHF-UCL.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016324	apical plasma membrane; IDA:BHF-UCL.
# GO_function	GO:0000166	nucleotide binding; TAS:ProtInc.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0008513	secondary active organic cation transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015226	carnitine transmembrane transporter activity; IDA:MGI.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_function	GO:0015651	quaternary ammonium group transmembrane transporter activity; IDA:BHF-UCL.
# GO_function	GO:0030165	PDZ domain binding; IPI:BHF-UCL.
# GO_function	S22A4_HUMAN	GO 0015491 cation cation antiporter activity; IDA BHF-UCL.
# GO_process	GO:0006641	triglyceride metabolic process; IEA:Ensembl.
# GO_process	GO:0006814	sodium ion transport; IEA:UniProtKB-KW.
# GO_process	GO:0007589	body fluid secretion; TAS:ProtInc.
# GO_process	GO:0009437	carnitine metabolic process; IBA:GO_Central.
# GO_process	GO:0015695	organic cation transport; TAS:ProtInc.
# GO_process	GO:0015697	quaternary ammonium group transport; IDA:BHF-UCL.
# GO_process	GO:0015879	carnitine transport; IDA:MGI.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# Genevisible	Q9H015	HS
# HGNC	HGNC:10968	SLC22A4
# INDUCTION	Overexpressed upon TNF treatment. {ECO:0000269|PubMed	14608356}. 
# InterPro	IPR004749	Orgcat_transp/SVOP
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR005829	Sugar_transporter_CS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H00286	[Immune system disease] Crohn's disease
# MIM	180300	phenotype
# MIM	604190	gene
# Organism	S22A4_HUMAN	Homo sapiens (Human)
# PROSITE	PS00216	SUGAR_TRANSPORT_1
# PROSITE	PS50850	MFS
# Pfam	PF00083	Sugar_tr
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-549127	Organic cation transport
# RecName	S22A4_HUMAN	Solute carrier family 22 member 4
# RefSeq	NP_003050	NM_003059.2
# SIMILARITY	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S22A4_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Interacts with PDZK1. {ECO	0000250}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.19	the major facilitator superfamily (mfs)
# TIGRFAMs	TIGR00898	2A0119
# TISSUE SPECIFICITY	S22A4_HUMAN	Widely expressed. Highly expressed in whole blood, bone marrow, trachea and fetal liver. Weakly expressed in kidney, skeletal muscle, prostate, lung, pancreas, placenta, heart, uterus, spleen and spinal cord. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells. Predominantly expressed in CD14 cells in peripheral blood mononuclear cells. {ECO 0000269|PubMed 14608356, ECO 0000269|PubMed 15107849, ECO 0000269|PubMed 9426230}. 
# UCSC	uc003kwq	human
# eggNOG	ENOG410IRIE	Eukaryota
# eggNOG	ENOG410XSRI	LUCA
BLAST	swissprot:S22A4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S22A4_HUMAN
BioCyc	ZFISH:ENSG00000072703-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000072703-MONOMER
COXPRESdb	6583	http://coxpresdb.jp/data/gene/6583.shtml
CleanEx	HS_SLC22A4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC22A4
DOI	10.1002/jps.20190	http://dx.doi.org/10.1002/jps.20190
DOI	10.1007/s100380200088	http://dx.doi.org/10.1007/s100380200088
DOI	10.1016/S0014-5793(97)01441-5	http://dx.doi.org/10.1016/S0014-5793(97)01441-5
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1038/ng1267	http://dx.doi.org/10.1038/ng1267
DOI	10.1038/ng1339	http://dx.doi.org/10.1038/ng1339
DOI	10.1073/pnas.0408624102	http://dx.doi.org/10.1073/pnas.0408624102
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00122	http://www.drugbank.ca/drugs/DB00122
DrugBank	DB00123	http://www.drugbank.ca/drugs/DB00123
DrugBank	DB00125	http://www.drugbank.ca/drugs/DB00125
DrugBank	DB00127	http://www.drugbank.ca/drugs/DB00127
DrugBank	DB00184	http://www.drugbank.ca/drugs/DB00184
DrugBank	DB00332	http://www.drugbank.ca/drugs/DB00332
DrugBank	DB00345	http://www.drugbank.ca/drugs/DB00345
DrugBank	DB00458	http://www.drugbank.ca/drugs/DB00458
DrugBank	DB00468	http://www.drugbank.ca/drugs/DB00468
DrugBank	DB00501	http://www.drugbank.ca/drugs/DB00501
DrugBank	DB00536	http://www.drugbank.ca/drugs/DB00536
DrugBank	DB00575	http://www.drugbank.ca/drugs/DB00575
DrugBank	DB00583	http://www.drugbank.ca/drugs/DB00583
DrugBank	DB00594	http://www.drugbank.ca/drugs/DB00594
DrugBank	DB00624	http://www.drugbank.ca/drugs/DB00624
DrugBank	DB00661	http://www.drugbank.ca/drugs/DB00661
DrugBank	DB00908	http://www.drugbank.ca/drugs/DB00908
DrugBank	DB01035	http://www.drugbank.ca/drugs/DB01035
DrugBank	DB01053	http://www.drugbank.ca/drugs/DB01053
DrugBank	DB01137	http://www.drugbank.ca/drugs/DB01137
DrugBank	DB01151	http://www.drugbank.ca/drugs/DB01151
DrugBank	DB01165	http://www.drugbank.ca/drugs/DB01165
DrugBank	DB01409	http://www.drugbank.ca/drugs/DB01409
DrugBank	DB06691	http://www.drugbank.ca/drugs/DB06691
EMBL	AB007448	http://www.ebi.ac.uk/ena/data/view/AB007448
EMBL	AC008599	http://www.ebi.ac.uk/ena/data/view/AC008599
EMBL	AC034220	http://www.ebi.ac.uk/ena/data/view/AC034220
EMBL	BC028313	http://www.ebi.ac.uk/ena/data/view/BC028313
EMBL	Y09881	http://www.ebi.ac.uk/ena/data/view/Y09881
Ensembl	ENST00000200652	http://www.ensembl.org/id/ENST00000200652
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_function	GO:0000166	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0008513	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008513
GO_function	GO:0015226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015226
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_function	GO:0015491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015491
GO_function	GO:0015651	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015651
GO_function	GO:0030165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030165
GO_process	GO:0006641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006641
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0007589	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007589
GO_process	GO:0009437	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009437
GO_process	GO:0015695	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015695
GO_process	GO:0015697	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015697
GO_process	GO:0015879	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015879
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GeneCards	SLC22A4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC22A4
GeneID	6583	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6583
GeneTree	ENSGT00760000118852	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118852
H-InvDB	HIX0024844	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0024844
HGNC	HGNC:10968	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10968
HOGENOM	HOG000234570	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234570&db=HOGENOM6
HOVERGEN	HBG061545	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG061545&db=HOVERGEN
HPA	CAB015468	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB015468
InParanoid	Q9H015	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9H015
InterPro	IPR004749	http://www.ebi.ac.uk/interpro/entry/IPR004749
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR005829	http://www.ebi.ac.uk/interpro/entry/IPR005829
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	6583	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6583
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00286	http://www.genome.jp/dbget-bin/www_bget?H00286
KEGG_Gene	hsa:6583	http://www.genome.jp/dbget-bin/www_bget?hsa:6583
KEGG_Orthology	KO:K08202	http://www.genome.jp/dbget-bin/www_bget?KO:K08202
MIM	180300	http://www.ncbi.nlm.nih.gov/omim/180300
MIM	604190	http://www.ncbi.nlm.nih.gov/omim/604190
OMA	IAIMTIM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IAIMTIM
OrthoDB	EOG091G05AC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05AC
PROSITE	PS00216	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00216
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:S22A4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S22A4_HUMAN
PSORT-B	swissprot:S22A4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S22A4_HUMAN
PSORT2	swissprot:S22A4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S22A4_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
PharmGKB	PA332	http://www.pharmgkb.org/do/serve?objId=PA332&objCls=Gene
Phobius	swissprot:S22A4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S22A4_HUMAN
PhylomeDB	Q9H015	http://phylomedb.org/?seqid=Q9H015
ProteinModelPortal	Q9H015	http://www.proteinmodelportal.org/query/uniprot/Q9H015
PubMed	10215651	http://www.ncbi.nlm.nih.gov/pubmed/10215651
PubMed	12436193	http://www.ncbi.nlm.nih.gov/pubmed/12436193
PubMed	14608356	http://www.ncbi.nlm.nih.gov/pubmed/14608356
PubMed	15107849	http://www.ncbi.nlm.nih.gov/pubmed/15107849
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	15459889	http://www.ncbi.nlm.nih.gov/pubmed/15459889
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15795384	http://www.ncbi.nlm.nih.gov/pubmed/15795384
PubMed	9426230	http://www.ncbi.nlm.nih.gov/pubmed/9426230
Reactome	R-HSA-549127	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-549127
RefSeq	NP_003050	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003050
STRING	9606.ENSP00000200652	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000200652&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.19	http://www.tcdb.org/search/result.php?tc=2.A.1.19
TIGRFAMs	TIGR00898	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00898
UCSC	uc003kwq	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003kwq&org=rat
UniGene	Hs.310591	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.310591
UniProtKB	S22A4_HUMAN	http://www.uniprot.org/uniprot/S22A4_HUMAN
UniProtKB-AC	Q9H015	http://www.uniprot.org/uniprot/Q9H015
charge	swissprot:S22A4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S22A4_HUMAN
eggNOG	ENOG410IRIE	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IRIE
eggNOG	ENOG410XSRI	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSRI
epestfind	swissprot:S22A4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S22A4_HUMAN
garnier	swissprot:S22A4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S22A4_HUMAN
helixturnhelix	swissprot:S22A4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S22A4_HUMAN
hmoment	swissprot:S22A4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S22A4_HUMAN
iep	swissprot:S22A4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S22A4_HUMAN
inforesidue	swissprot:S22A4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S22A4_HUMAN
neXtProt	NX_Q9H015	http://www.nextprot.org/db/entry/NX_Q9H015
octanol	swissprot:S22A4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S22A4_HUMAN
pepcoil	swissprot:S22A4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S22A4_HUMAN
pepdigest	swissprot:S22A4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S22A4_HUMAN
pepinfo	swissprot:S22A4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S22A4_HUMAN
pepnet	swissprot:S22A4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S22A4_HUMAN
pepstats	swissprot:S22A4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S22A4_HUMAN
pepwheel	swissprot:S22A4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S22A4_HUMAN
pepwindow	swissprot:S22A4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S22A4_HUMAN
sigcleave	swissprot:S22A4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S22A4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SCN2A_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Adult, 6A; IsoId=Q99250-1; Sequence=Displayed; Name=2; Synonyms=Neonatal, 6N; IsoId=Q99250-2; Sequence=VSP_001032; 
# AltName	SCN2A_HUMAN	HBSC II
# AltName	SCN2A_HUMAN	Sodium channel protein brain II subunit alpha
# AltName	SCN2A_HUMAN	Sodium channel protein type II subunit alpha
# AltName	SCN2A_HUMAN	Voltage-gated sodium channel subunit alpha Nav1.2
# CCDS	CCDS33313	-. [Q99250-2]
# CCDS	CCDS33314	-. [Q99250-1]
# ChiTaRS	SCN2A	human
# DISEASE	SCN2A_HUMAN	Epileptic encephalopathy, early infantile, 11 (EIEE11) [MIM 613721]  An autosomal dominant seizure disorder characterized by neonatal or infantile onset of refractory seizures with resultant delayed neurologic development and persistent neurologic abnormalities. Patients may progress to West syndrome, which is characterized by tonic spasms with clustering, arrest of psychomotor development, and hypsarrhythmia on EEG. {ECO 0000269|PubMed 19783390, ECO 0000269|PubMed 19786696, ECO 0000269|PubMed 20956790, ECO 0000269|PubMed 23550958, ECO 0000269|PubMed 23935176}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCN2A_HUMAN	Seizures, benign familial infantile, 3 (BFIS3) [MIM 607745]  A form of benign familial infantile epilepsy, a neurologic disorder characterized by afebrile seizures occurring in clusters during the first year of life, without neurologic sequelae. BFIS3 inheritance is autosomal dominant. {ECO 0000269|PubMed 11371648, ECO 0000269|PubMed 12243921, ECO 0000269|PubMed 15048894, ECO 0000269|PubMed 20371507, ECO 0000269|PubMed 22612257}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	SCN2A_HUMAN	The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position. 
# DrugBank	DB00313	Valproic Acid
# DrugBank	DB00555	Lamotrigine
# DrugBank	DB00818	Propofol
# DrugBank	DB00909	Zonisamide
# Ensembl	ENST00000283256	ENSP00000283256; ENSG00000136531. [Q99250-1]
# Ensembl	ENST00000375427	ENSP00000364576; ENSG00000136531. [Q99250-2]
# Ensembl	ENST00000375437	ENSP00000364586; ENSG00000136531. [Q99250-1]
# Ensembl	ENST00000631182	ENSP00000486885; ENSG00000136531. [Q99250-2]
# Ensembl	ENST00000636071	ENSP00000490107; ENSG00000136531. [Q99250-2]
# Ensembl	ENST00000637266	ENSP00000490866; ENSG00000136531. [Q99250-1]
# ExpressionAtlas	Q99250	baseline and differential
# FUNCTION	SCN2A_HUMAN	Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. {ECO 0000269|PubMed 1325650}. 
# GO_component	GO:0001518	voltage-gated sodium channel complex; IEA:InterPro.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0030424	axon; TAS:BHF-UCL.
# GO_component	GO:0031226	intrinsic component of plasma membrane; ISS:UniProtKB.
# GO_component	GO:0033268	node of Ranvier; ISS:BHF-UCL.
# GO_component	GO:0034706	sodium channel complex; ISS:UniProtKB.
# GO_function	GO:0005248	voltage-gated sodium channel activity; ISS:UniProtKB.
# GO_process	GO:0006814	sodium ion transport; TAS:ProtInc.
# GO_process	GO:0019228	neuronal action potential; IBA:GO_Central.
# GO_process	GO:0035725	sodium ion transmembrane transport; ISS:UniProtKB.
# GO_process	GO:0042552	myelination; ISS:BHF-UCL.
# GO_process	GO:0086010	membrane depolarization during action potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.350	-; 4.
# Genevisible	Q99250	HS
# HGNC	HGNC:10588	SCN2A
# IntAct	Q99250	4
# InterPro	IPR000048	IQ_motif_EF-hand-BS
# InterPro	IPR001696	Na_channel_asu
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR010526	Na_trans_assoc
# InterPro	IPR024583	Na_trans_cytopl
# InterPro	IPR027359	Channel_four-helix_dom
# KEGG_Brite	ko04040	Ion channels
# KEGG_Disease	H00606	[Congenital disorder; Epilepsy] Ohtahara syndrome
# KEGG_Disease	H00806	[Nervous system disease] Benign familial infantile epilepsy (BFIE)
# MIM	182390	gene
# MIM	607745	phenotype
# MIM	613721	phenotype
# Organism	SCN2A_HUMAN	Homo sapiens (Human)
# Orphanet	140927	Benign familial neonatal-infantile seizures
# Orphanet	1934	Early infantile epileptic encephalopathy
# Orphanet	306	Benign familial infantile epilepsy
# Orphanet	33069	Dravet syndrome
# Orphanet	3451	West syndrome
# Orphanet	36387	Generalized epilepsy with febrile seizures-plus
# PDB	2KAV	NMR; -; A=1777-1882
# PDB	4JPZ	X-ray; 3.02 A; B/H=1777-1937
# PIR	A46269	A46269
# PIR	I59194	I59194
# PRINTS	PR00170	NACHANNEL
# PROSITE	PS50096	IQ
# PTM	SCN2A_HUMAN	May be ubiquitinated by NEDD4L; which would promote its endocytosis. {ECO 0000250}. 
# PTM	SCN2A_HUMAN	Phosphorylation at Ser-1506 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents. {ECO 0000250}. 
# Pfam	PF00520	Ion_trans; 4
# Pfam	PF06512	Na_trans_assoc
# Pfam	PF11933	Na_trans_cytopl
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-445095	Interaction between L1 and Ankyrins
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# RecName	SCN2A_HUMAN	Sodium channel protein type 2 subunit alpha
# RefSeq	NP_001035232	NM_001040142.1. [Q99250-1]
# RefSeq	NP_001035233	NM_001040143.1. [Q99250-2]
# RefSeq	NP_066287	NM_021007.2. [Q99250-1]
# RefSeq	XP_005246810	XM_005246753.3. [Q99250-2]
# RefSeq	XP_016860144	XM_017004655.1. [Q99250-1]
# RefSeq	XP_016860145	XM_017004656.1. [Q99250-1]
# RefSeq	XP_016860146	XM_017004657.1. [Q99250-2]
# SEQUENCE CAUTION	Sequence=CAA46438.1; Type=Frameshift; Positions=1953; Evidence={ECO:0000305}; Sequence=CAA46438.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.2/SCN2A subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 IQ domain. {ECO:0000255|PROSITE- ProRule	PRU00116}. 
# SMART	SM00015	IQ
# SUBCELLULAR LOCATION	SCN2A_HUMAN	Cell membrane {ECO 0000269|PubMed 1325650}; Multi-pass membrane protein {ECO 0000269|PubMed 1325650}. 
# SUBUNIT	Interacts with NEDD4L. Interacts with CALM (By similarity). Heterooligomer of a large alpha subunit and a smaller beta subunit. Heterooligomer with SCN4B; disulfide-linked. {ECO:0000250, ECO	0000269|PubMed:24297919}. 
# TCDB	1.A.1.10.12	the voltage-gated ion channel (vic) superfamily
# UCSC	uc002udc	human. [Q99250-1]
# eggNOG	COG1226	LUCA
# eggNOG	ENOG410INF8	Eukaryota
BLAST	swissprot:SCN2A_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SCN2A_HUMAN
BioCyc	ZFISH:ENSG00000136531-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000136531-MONOMER
COXPRESdb	6326	http://coxpresdb.jp/data/gene/6326.shtml
CleanEx	HS_SCN2A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SCN2A
DOI	10.1002/ana.20029	http://dx.doi.org/10.1002/ana.20029
DOI	10.1016/0014-5793(92)80476-W	http://dx.doi.org/10.1016/0014-5793(92)80476-W
DOI	10.1016/S0140-6736(02)09968-3	http://dx.doi.org/10.1016/S0140-6736(02)09968-3
DOI	10.1016/S0378-1119(00)00594-1	http://dx.doi.org/10.1016/S0378-1119(00)00594-1
DOI	10.1016/j.braindev.2004.11.005	http://dx.doi.org/10.1016/j.braindev.2004.11.005
DOI	10.1016/j.braindev.2009.08.009	http://dx.doi.org/10.1016/j.braindev.2009.08.009
DOI	10.1016/j.eplepsyres.2015.08.001	http://dx.doi.org/10.1016/j.eplepsyres.2015.08.001
DOI	10.1016/j.pediatrneurol.2013.03.002	http://dx.doi.org/10.1016/j.pediatrneurol.2013.03.002
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/sj.mp.4001241	http://dx.doi.org/10.1038/sj.mp.4001241
DOI	10.1073/pnas.111065098	http://dx.doi.org/10.1073/pnas.111065098
DOI	10.1073/pnas.1314557110	http://dx.doi.org/10.1073/pnas.1314557110
DOI	10.1073/pnas.88.2.335	http://dx.doi.org/10.1073/pnas.88.2.335
DOI	10.1073/pnas.89.17.8220	http://dx.doi.org/10.1073/pnas.89.17.8220
DOI	10.1093/brain/awq057	http://dx.doi.org/10.1093/brain/awq057
DOI	10.1111/epi.12137	http://dx.doi.org/10.1111/epi.12137
DOI	10.1111/j.1528-1167.2012.03516.x	http://dx.doi.org/10.1111/j.1528-1167.2012.03516.x
DOI	10.1212/WNL.0b013e3181b9cebc	http://dx.doi.org/10.1212/WNL.0b013e3181b9cebc
DOI	10.1212/WNL.0b013e3181f8812e	http://dx.doi.org/10.1212/WNL.0b013e3181f8812e
DOI	10.1212/WNL.0b013e3182a43e57	http://dx.doi.org/10.1212/WNL.0b013e3182a43e57
DrugBank	DB00313	http://www.drugbank.ca/drugs/DB00313
DrugBank	DB00555	http://www.drugbank.ca/drugs/DB00555
DrugBank	DB00818	http://www.drugbank.ca/drugs/DB00818
DrugBank	DB00909	http://www.drugbank.ca/drugs/DB00909
EMBL	AC011303	http://www.ebi.ac.uk/ena/data/view/AC011303
EMBL	AC013438	http://www.ebi.ac.uk/ena/data/view/AC013438
EMBL	AF059683	http://www.ebi.ac.uk/ena/data/view/AF059683
EMBL	AF327226	http://www.ebi.ac.uk/ena/data/view/AF327226
EMBL	AF327226	http://www.ebi.ac.uk/ena/data/view/AF327226
EMBL	AF327227	http://www.ebi.ac.uk/ena/data/view/AF327227
EMBL	AF327227	http://www.ebi.ac.uk/ena/data/view/AF327227
EMBL	AF327228	http://www.ebi.ac.uk/ena/data/view/AF327228
EMBL	AF327228	http://www.ebi.ac.uk/ena/data/view/AF327228
EMBL	AF327229	http://www.ebi.ac.uk/ena/data/view/AF327229
EMBL	AF327229	http://www.ebi.ac.uk/ena/data/view/AF327229
EMBL	AF327230	http://www.ebi.ac.uk/ena/data/view/AF327230
EMBL	AF327230	http://www.ebi.ac.uk/ena/data/view/AF327230
EMBL	AF327231	http://www.ebi.ac.uk/ena/data/view/AF327231
EMBL	AF327231	http://www.ebi.ac.uk/ena/data/view/AF327231
EMBL	AF327232	http://www.ebi.ac.uk/ena/data/view/AF327232
EMBL	AF327232	http://www.ebi.ac.uk/ena/data/view/AF327232
EMBL	AF327233	http://www.ebi.ac.uk/ena/data/view/AF327233
EMBL	AF327233	http://www.ebi.ac.uk/ena/data/view/AF327233
EMBL	AF327234	http://www.ebi.ac.uk/ena/data/view/AF327234
EMBL	AF327234	http://www.ebi.ac.uk/ena/data/view/AF327234
EMBL	AF327235	http://www.ebi.ac.uk/ena/data/view/AF327235
EMBL	AF327235	http://www.ebi.ac.uk/ena/data/view/AF327235
EMBL	AF327236	http://www.ebi.ac.uk/ena/data/view/AF327236
EMBL	AF327236	http://www.ebi.ac.uk/ena/data/view/AF327236
EMBL	AF327237	http://www.ebi.ac.uk/ena/data/view/AF327237
EMBL	AF327237	http://www.ebi.ac.uk/ena/data/view/AF327237
EMBL	AF327238	http://www.ebi.ac.uk/ena/data/view/AF327238
EMBL	AF327238	http://www.ebi.ac.uk/ena/data/view/AF327238
EMBL	AF327239	http://www.ebi.ac.uk/ena/data/view/AF327239
EMBL	AF327239	http://www.ebi.ac.uk/ena/data/view/AF327239
EMBL	AF327240	http://www.ebi.ac.uk/ena/data/view/AF327240
EMBL	AF327240	http://www.ebi.ac.uk/ena/data/view/AF327240
EMBL	AF327241	http://www.ebi.ac.uk/ena/data/view/AF327241
EMBL	AF327241	http://www.ebi.ac.uk/ena/data/view/AF327241
EMBL	AF327242	http://www.ebi.ac.uk/ena/data/view/AF327242
EMBL	AF327242	http://www.ebi.ac.uk/ena/data/view/AF327242
EMBL	AF327243	http://www.ebi.ac.uk/ena/data/view/AF327243
EMBL	AF327243	http://www.ebi.ac.uk/ena/data/view/AF327243
EMBL	AF327244	http://www.ebi.ac.uk/ena/data/view/AF327244
EMBL	AF327244	http://www.ebi.ac.uk/ena/data/view/AF327244
EMBL	AF327245	http://www.ebi.ac.uk/ena/data/view/AF327245
EMBL	AF327245	http://www.ebi.ac.uk/ena/data/view/AF327245
EMBL	AF327246	http://www.ebi.ac.uk/ena/data/view/AF327246
EMBL	AF327246	http://www.ebi.ac.uk/ena/data/view/AF327246
EMBL	M55662	http://www.ebi.ac.uk/ena/data/view/M55662
EMBL	M91804	http://www.ebi.ac.uk/ena/data/view/M91804
EMBL	M94055	http://www.ebi.ac.uk/ena/data/view/M94055
EMBL	X65361	http://www.ebi.ac.uk/ena/data/view/X65361
Ensembl	ENST00000283256	http://www.ensembl.org/id/ENST00000283256
Ensembl	ENST00000375427	http://www.ensembl.org/id/ENST00000375427
Ensembl	ENST00000375437	http://www.ensembl.org/id/ENST00000375437
Ensembl	ENST00000631182	http://www.ensembl.org/id/ENST00000631182
Ensembl	ENST00000636071	http://www.ensembl.org/id/ENST00000636071
Ensembl	ENST00000637266	http://www.ensembl.org/id/ENST00000637266
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0001518	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001518
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0030424	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030424
GO_component	GO:0031226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031226
GO_component	GO:0033268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033268
GO_component	GO:0034706	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034706
GO_function	GO:0005248	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005248
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0019228	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019228
GO_process	GO:0035725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035725
GO_process	GO:0042552	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042552
GO_process	GO:0086010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086010
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	SCN2A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SCN2A
GeneID	6326	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6326
GeneTree	ENSGT00830000128242	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00830000128242
H-InvDB	HIX0029932	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0029932
HGNC	HGNC:10588	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10588
HOVERGEN	HBG053100	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053100&db=HOVERGEN
HPA	CAB022567	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB022567
InParanoid	Q99250	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q99250
IntAct	Q99250	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q99250*
InterPro	IPR000048	http://www.ebi.ac.uk/interpro/entry/IPR000048
InterPro	IPR001696	http://www.ebi.ac.uk/interpro/entry/IPR001696
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR010526	http://www.ebi.ac.uk/interpro/entry/IPR010526
InterPro	IPR024583	http://www.ebi.ac.uk/interpro/entry/IPR024583
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
Jabion	6326	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6326
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00606	http://www.genome.jp/dbget-bin/www_bget?H00606
KEGG_Disease	H00806	http://www.genome.jp/dbget-bin/www_bget?H00806
KEGG_Gene	hsa:6326	http://www.genome.jp/dbget-bin/www_bget?hsa:6326
KEGG_Orthology	KO:K04834	http://www.genome.jp/dbget-bin/www_bget?KO:K04834
MIM	182390	http://www.ncbi.nlm.nih.gov/omim/182390
MIM	607745	http://www.ncbi.nlm.nih.gov/omim/607745
MIM	613721	http://www.ncbi.nlm.nih.gov/omim/613721
MINT	MINT-1388751	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1388751
OMA	DQTKEMD	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DQTKEMD
Orphanet	140927	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=140927
Orphanet	1934	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1934
Orphanet	306	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=306
Orphanet	33069	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=33069
Orphanet	3451	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=3451
Orphanet	36387	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=36387
OrthoDB	EOG091G00FK	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00FK
PDB	2KAV	http://www.ebi.ac.uk/pdbe-srv/view/entry/2KAV
PDB	4JPZ	http://www.ebi.ac.uk/pdbe-srv/view/entry/4JPZ
PDBsum	2KAV	http://www.ebi.ac.uk/pdbsum/2KAV
PDBsum	4JPZ	http://www.ebi.ac.uk/pdbsum/4JPZ
PRINTS	PR00170	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00170
PROSITE	PS50096	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50096
PSORT	swissprot:SCN2A_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SCN2A_HUMAN
PSORT-B	swissprot:SCN2A_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SCN2A_HUMAN
PSORT2	swissprot:SCN2A_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SCN2A_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF06512	http://pfam.xfam.org/family/PF06512
Pfam	PF11933	http://pfam.xfam.org/family/PF11933
PharmGKB	PA35004	http://www.pharmgkb.org/do/serve?objId=PA35004&objCls=Gene
Phobius	swissprot:SCN2A_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SCN2A_HUMAN
PhylomeDB	Q99250	http://phylomedb.org/?seqid=Q99250
ProteinModelPortal	Q99250	http://www.proteinmodelportal.org/query/uniprot/Q99250
PubMed	11245985	http://www.ncbi.nlm.nih.gov/pubmed/11245985
PubMed	11371648	http://www.ncbi.nlm.nih.gov/pubmed/11371648
PubMed	12243921	http://www.ncbi.nlm.nih.gov/pubmed/12243921
PubMed	12610651	http://www.ncbi.nlm.nih.gov/pubmed/12610651
PubMed	1317301	http://www.ncbi.nlm.nih.gov/pubmed/1317301
PubMed	1325650	http://www.ncbi.nlm.nih.gov/pubmed/1325650
PubMed	15048894	http://www.ncbi.nlm.nih.gov/pubmed/15048894
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	16122630	http://www.ncbi.nlm.nih.gov/pubmed/16122630
PubMed	1846440	http://www.ncbi.nlm.nih.gov/pubmed/1846440
PubMed	19783390	http://www.ncbi.nlm.nih.gov/pubmed/19783390
PubMed	19786696	http://www.ncbi.nlm.nih.gov/pubmed/19786696
PubMed	20371507	http://www.ncbi.nlm.nih.gov/pubmed/20371507
PubMed	20956790	http://www.ncbi.nlm.nih.gov/pubmed/20956790
PubMed	22612257	http://www.ncbi.nlm.nih.gov/pubmed/22612257
PubMed	23550958	http://www.ncbi.nlm.nih.gov/pubmed/23550958
PubMed	23827426	http://www.ncbi.nlm.nih.gov/pubmed/23827426
PubMed	23935176	http://www.ncbi.nlm.nih.gov/pubmed/23935176
PubMed	24297919	http://www.ncbi.nlm.nih.gov/pubmed/24297919
PubMed	26311622	http://www.ncbi.nlm.nih.gov/pubmed/26311622
Reactome	R-HSA-445095	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-445095
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
RefSeq	NP_001035232	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001035232
RefSeq	NP_001035233	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001035233
RefSeq	NP_066287	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_066287
RefSeq	XP_005246810	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005246810
RefSeq	XP_016860144	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016860144
RefSeq	XP_016860145	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016860145
RefSeq	XP_016860146	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016860146
SMART	SM00015	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00015
SMR	Q99250	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q99250
STRING	9606.ENSP00000283256	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000283256&targetmode=cogs
TCDB	1.A.1.10.12	http://www.tcdb.org/search/result.php?tc=1.A.1.10.12
UCSC	uc002udc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002udc&org=rat
UniGene	Hs.93485	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.93485
UniProtKB	SCN2A_HUMAN	http://www.uniprot.org/uniprot/SCN2A_HUMAN
UniProtKB-AC	Q99250	http://www.uniprot.org/uniprot/Q99250
charge	swissprot:SCN2A_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SCN2A_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	ENOG410INF8	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410INF8
epestfind	swissprot:SCN2A_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SCN2A_HUMAN
garnier	swissprot:SCN2A_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SCN2A_HUMAN
helixturnhelix	swissprot:SCN2A_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SCN2A_HUMAN
hmoment	swissprot:SCN2A_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SCN2A_HUMAN
iep	swissprot:SCN2A_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SCN2A_HUMAN
inforesidue	swissprot:SCN2A_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SCN2A_HUMAN
neXtProt	NX_Q99250	http://www.nextprot.org/db/entry/NX_Q99250
octanol	swissprot:SCN2A_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SCN2A_HUMAN
pepcoil	swissprot:SCN2A_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SCN2A_HUMAN
pepdigest	swissprot:SCN2A_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SCN2A_HUMAN
pepinfo	swissprot:SCN2A_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SCN2A_HUMAN
pepnet	swissprot:SCN2A_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SCN2A_HUMAN
pepstats	swissprot:SCN2A_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SCN2A_HUMAN
pepwheel	swissprot:SCN2A_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SCN2A_HUMAN
pepwindow	swissprot:SCN2A_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SCN2A_HUMAN
sigcleave	swissprot:SCN2A_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SCN2A_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GBRR1_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P24046-1; Sequence=Displayed; Name=2; IsoId=P24046-2; Sequence=VSP_036363; Note=No experimental confirmation available.; Name=3; IsoId=P24046-3; Sequence=VSP_046665; Note=No experimental confirmation available.; 
# AltName	GBRR1_HUMAN	GABA(A) receptor subunit rho-1
# AltName	GBRR1_HUMAN	GABA(C) receptor
# BioGrid	108843	12
# CCDS	CCDS5019	-. [P24046-1]
# CCDS	CCDS59028	-. [P24046-3]
# CCDS	CCDS59029	-. [P24046-2]
# DrugBank	DB00231	Temazepam
# DrugBank	DB00546	Adinazolam
# DrugBank	DB00683	Midazolam
# DrugBank	DB00690	Flurazepam
# DrugBank	DB00801	Halazepam
# DrugBank	DB00829	Diazepam
# DrugBank	DB00842	Oxazepam
# DrugBank	DB00897	Triazolam
# DrugBank	DB01215	Estazolam
# DrugBank	DB01558	Bromazepam
# DrugBank	DB01559	Clotiazepam
# DrugBank	DB01567	Fludiazepam
# DrugBank	DB01588	Prazepam
# DrugBank	DB01589	Quazepam
# DrugBank	DB01594	Cinolazepam
# DrugBank	DB01595	Nitrazepam
# Ensembl	ENST00000369451	ENSP00000358463; ENSG00000146276. [P24046-3]
# Ensembl	ENST00000435811	ENSP00000394687; ENSG00000146276. [P24046-2]
# Ensembl	ENST00000454853	ENSP00000412673; ENSG00000146276. [P24046-1]
# Ensembl	ENST00000611484	ENSP00000478846; ENSG00000146276. [P24046-3]
# Ensembl	ENST00000621627	ENSP00000481986; ENSG00000146276. [P24046-3]
# ExpressionAtlas	P24046	baseline and differential
# FUNCTION	GBRR1_HUMAN	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:1902711	GABA-A receptor complex; IBA:GO_Central.
# GO_function	GO:0004890	GABA-A receptor activity; TAS:ProtInc.
# GO_function	GO:0005230	extracellular ligand-gated ion channel activity; IEA:InterPro.
# GO_function	GO:0005254	chloride channel activity; IEA:UniProtKB-KW.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007214	gamma-aminobutyric acid signaling pathway; TAS:ProtInc.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:ProtInc.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.70.170.10	-; 1.
# Genevisible	P24046	HS
# HGNC	HGNC:4090	GABRR1
# InterPro	IPR006028	GABAA/Glycine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR008057	GABAAa_rho_rcpt
# InterPro	IPR008058	GABAAa_rho1_rcpt
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04727	GABAergic synapse
# KEGG_Pathway	ko05032	Morphine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# MIM	137161	gene
# Organism	GBRR1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR18945	PTHR18945
# PIR	A38627	A38627
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00253	GABAARECEPTR
# PRINTS	PR01670	GABAARRHO
# PRINTS	PR01671	GABAARRHO1
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-975298	Ligand-gated ion channel transport
# Reactome	R-HSA-977442	GABA A (rho) receptor activation
# RecName	GBRR1_HUMAN	Gamma-aminobutyric acid receptor subunit rho-1
# RefSeq	NP_001243632	NM_001256703.1. [P24046-2]
# RefSeq	NP_001243633	NM_001256704.1. [P24046-3]
# RefSeq	NP_001254511	NM_001267582.1. [P24046-3]
# RefSeq	NP_002033	NM_002042.4. [P24046-1]
# RefSeq	XP_016866178	XM_017010689.1. [P24046-3]
# SEQUENCE CAUTION	Sequence=AAA52509.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI30345.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR1 sub-subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	GBRR1_HUMAN	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1 (By similarity). {ECO	0000250}. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TCDB	1.A.9.5	the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family
# TIGRFAMs	TIGR00860	LIC
# TISSUE SPECIFICITY	GBRR1_HUMAN	Highly expressed in the retina and in a lesser extent in brain, lung and thymus. 
# UCSC	uc003pna	human. [P24046-1]
# eggNOG	ENOG410XPWH	LUCA
# eggNOG	KOG3643	Eukaryota
BLAST	swissprot:GBRR1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GBRR1_HUMAN
COXPRESdb	2569	http://coxpresdb.jp/data/gene/2569.shtml
CleanEx	HS_GABRR1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GABRR1
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.88.7.2673	http://dx.doi.org/10.1073/pnas.88.7.2673
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00231	http://www.drugbank.ca/drugs/DB00231
DrugBank	DB00546	http://www.drugbank.ca/drugs/DB00546
DrugBank	DB00683	http://www.drugbank.ca/drugs/DB00683
DrugBank	DB00690	http://www.drugbank.ca/drugs/DB00690
DrugBank	DB00801	http://www.drugbank.ca/drugs/DB00801
DrugBank	DB00829	http://www.drugbank.ca/drugs/DB00829
DrugBank	DB00842	http://www.drugbank.ca/drugs/DB00842
DrugBank	DB00897	http://www.drugbank.ca/drugs/DB00897
DrugBank	DB01215	http://www.drugbank.ca/drugs/DB01215
DrugBank	DB01558	http://www.drugbank.ca/drugs/DB01558
DrugBank	DB01559	http://www.drugbank.ca/drugs/DB01559
DrugBank	DB01567	http://www.drugbank.ca/drugs/DB01567
DrugBank	DB01588	http://www.drugbank.ca/drugs/DB01588
DrugBank	DB01589	http://www.drugbank.ca/drugs/DB01589
DrugBank	DB01594	http://www.drugbank.ca/drugs/DB01594
DrugBank	DB01595	http://www.drugbank.ca/drugs/DB01595
EMBL	AK296124	http://www.ebi.ac.uk/ena/data/view/AK296124
EMBL	AK298948	http://www.ebi.ac.uk/ena/data/view/AK298948
EMBL	AL353135	http://www.ebi.ac.uk/ena/data/view/AL353135
EMBL	AL353135	http://www.ebi.ac.uk/ena/data/view/AL353135
EMBL	AL353659	http://www.ebi.ac.uk/ena/data/view/AL353659
EMBL	AL353659	http://www.ebi.ac.uk/ena/data/view/AL353659
EMBL	BC130344	http://www.ebi.ac.uk/ena/data/view/BC130344
EMBL	M62400	http://www.ebi.ac.uk/ena/data/view/M62400
Ensembl	ENST00000369451	http://www.ensembl.org/id/ENST00000369451
Ensembl	ENST00000435811	http://www.ensembl.org/id/ENST00000435811
Ensembl	ENST00000454853	http://www.ensembl.org/id/ENST00000454853
Ensembl	ENST00000611484	http://www.ensembl.org/id/ENST00000611484
Ensembl	ENST00000621627	http://www.ensembl.org/id/ENST00000621627
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_component	GO:1902711	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902711
GO_function	GO:0004890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004890
GO_function	GO:0005230	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005230
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007214	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007214
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	GABRR1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GABRR1
GeneID	2569	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2569
GeneTree	ENSGT00760000118821	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118821
HGNC	HGNC:4090	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4090
HOGENOM	HOG000231335	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231335&db=HOGENOM6
HOVERGEN	HBG051707	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051707&db=HOVERGEN
InParanoid	P24046	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24046
IntAct	P24046	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24046*
InterPro	IPR006028	http://www.ebi.ac.uk/interpro/entry/IPR006028
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR008057	http://www.ebi.ac.uk/interpro/entry/IPR008057
InterPro	IPR008058	http://www.ebi.ac.uk/interpro/entry/IPR008058
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
Jabion	2569	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2569
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:2569	http://www.genome.jp/dbget-bin/www_bget?hsa:2569
KEGG_Orthology	KO:K05190	http://www.genome.jp/dbget-bin/www_bget?KO:K05190
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
KEGG_Pathway	ko05032	http://www.genome.jp/kegg-bin/show_pathway?ko05032
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
MIM	137161	http://www.ncbi.nlm.nih.gov/omim/137161
OMA	RMMVQLA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RMMVQLA
OrthoDB	EOG091G0805	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0805
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00253	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00253
PRINTS	PR01670	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01670
PRINTS	PR01671	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01671
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:GBRR1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GBRR1_HUMAN
PSORT-B	swissprot:GBRR1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GBRR1_HUMAN
PSORT2	swissprot:GBRR1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GBRR1_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA28505	http://www.pharmgkb.org/do/serve?objId=PA28505&objCls=Gene
Phobius	swissprot:GBRR1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GBRR1_HUMAN
PhylomeDB	P24046	http://phylomedb.org/?seqid=P24046
ProteinModelPortal	P24046	http://www.proteinmodelportal.org/query/uniprot/P24046
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	1849271	http://www.ncbi.nlm.nih.gov/pubmed/1849271
Reactome	R-HSA-975298	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-975298
Reactome	R-HSA-977442	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-977442
RefSeq	NP_001243632	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243632
RefSeq	NP_001243633	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243633
RefSeq	NP_001254511	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001254511
RefSeq	NP_002033	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002033
RefSeq	XP_016866178	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016866178
SMR	P24046	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24046
STRING	9606.ENSP00000412673	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000412673&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TCDB	1.A.9.5	http://www.tcdb.org/search/result.php?tc=1.A.9.5
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc003pna	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003pna&org=rat
UniGene	Hs.99927	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.99927
UniProtKB	GBRR1_HUMAN	http://www.uniprot.org/uniprot/GBRR1_HUMAN
UniProtKB-AC	P24046	http://www.uniprot.org/uniprot/P24046
charge	swissprot:GBRR1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GBRR1_HUMAN
eggNOG	ENOG410XPWH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPWH
eggNOG	KOG3643	http://eggnogapi.embl.de/nog_data/html/tree/KOG3643
epestfind	swissprot:GBRR1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GBRR1_HUMAN
garnier	swissprot:GBRR1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GBRR1_HUMAN
helixturnhelix	swissprot:GBRR1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GBRR1_HUMAN
hmoment	swissprot:GBRR1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GBRR1_HUMAN
iep	swissprot:GBRR1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GBRR1_HUMAN
inforesidue	swissprot:GBRR1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GBRR1_HUMAN
neXtProt	NX_P24046	http://www.nextprot.org/db/entry/NX_P24046
octanol	swissprot:GBRR1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GBRR1_HUMAN
pepcoil	swissprot:GBRR1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GBRR1_HUMAN
pepdigest	swissprot:GBRR1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GBRR1_HUMAN
pepinfo	swissprot:GBRR1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GBRR1_HUMAN
pepnet	swissprot:GBRR1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GBRR1_HUMAN
pepstats	swissprot:GBRR1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GBRR1_HUMAN
pepwheel	swissprot:GBRR1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GBRR1_HUMAN
pepwindow	swissprot:GBRR1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GBRR1_HUMAN
sigcleave	swissprot:GBRR1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GBRR1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ZNT5_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8TAD4-1; Sequence=Displayed; Name=2; IsoId=Q8TAD4-2; Sequence=VSP_030254, VSP_030255, VSP_030256; Name=3; IsoId=Q8TAD4-3; Sequence=VSP_043673, VSP_043674; Note=No experimental confirmation available.; Name=4; IsoId=Q8TAD4-4; Sequence=VSP_045115, VSP_043673, VSP_043674; 
# AltName	ZNT5_HUMAN	Solute carrier family 30 member 5
# AltName	ZNT5_HUMAN	ZnT-like transporter 1
# BioGrid	122346	33
# CCDS	CCDS34173	-. [Q8TAD4-3]
# CCDS	CCDS3996	-. [Q8TAD4-1]
# CCDS	CCDS58955	-. [Q8TAD4-4]
# ChiTaRS	SLC30A5	human
# Ensembl	ENST00000380860	ENSP00000370241; ENSG00000145740. [Q8TAD4-3]
# Ensembl	ENST00000396591	ENSP00000379836; ENSG00000145740. [Q8TAD4-1]
# Ensembl	ENST00000502979	ENSP00000421251; ENSG00000145740. [Q8TAD4-4]
# ExpressionAtlas	Q8TAD4	baseline and differential
# FUNCTION	ZNT5_HUMAN	Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP. {ECO 0000269|PubMed 11904301, ECO 0000269|PubMed 11937503, ECO 0000269|PubMed 15276077, ECO 0000269|PubMed 15525635, ECO 0000269|PubMed 15994300}. 
# GO_component	GO:0005634	nucleus; IDA:HPA.
# GO_component	GO:0005730	nucleolus; IDA:HPA.
# GO_component	GO:0005794	Golgi apparatus; IDA:BHF-UCL.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:UniProtKB.
# GO_component	GO:0016020	membrane; IDA:MGI.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_component	GO:0030141	secretory granule; IDA:MGI.
# GO_component	GO:0030667	secretory granule membrane; TAS:Reactome.
# GO_function	GO:0005385	zinc ion transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0008270	zinc ion binding; NAS:UniProtKB.
# GO_process	GO:0006824	cobalt ion transport; IDA:MGI.
# GO_process	GO:0006829	zinc II ion transport; IDA:UniProtKB.
# GO_process	GO:0006882	cellular zinc ion homeostasis; IDA:UniProtKB.
# GO_process	GO:0010043	response to zinc ion; IDA:UniProtKB.
# GO_process	GO:0010155	regulation of proton transport; NAS:UniProtKB.
# GO_process	GO:0061088	regulation of sequestering of zinc ion; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005730	nucleolus
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# Gene3D	1.20.1510.10	-; 2.
# Genevisible	Q8TAD4	HS
# HGNC	HGNC:19089	SLC30A5
# INDUCTION	ZNT5_HUMAN	Down-regulated by ZNF658 in response to zinc. {ECO 0000269|PubMed 15276077, ECO 0000269|PubMed 25582195}. 
# IntAct	Q8TAD4	3
# InterPro	IPR002524	Cation_efflux
# InterPro	IPR027469	Cation_efflux_TMD
# KEGG_Brite	ko02001	Solute carrier family
# MIM	607819	gene
# MISCELLANEOUS	ZNT5_HUMAN	The histidine-rich loop is essential for ZNT5 and ZNT6 heterooligomeric complexes to activate TNAP. 
# Organism	ZNT5_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11562	PTHR11562; 2
# Pfam	PF01545	Cation_efflux
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-264876	Insulin processing
# Reactome	R-HSA-435368	Zinc efflux and compartmentalization by the SLC30 family
# RecName	ZNT5_HUMAN	Zinc transporter 5
# RefSeq	NP_001238898	NM_001251969.1. [Q8TAD4-4]
# RefSeq	NP_075053	NM_022902.4. [Q8TAD4-1]
# RefSeq	NP_076960	NM_024055.4. [Q8TAD4-3]
# SEQUENCE CAUTION	Sequence=BAB14258.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	ZNT5_HUMAN	Golgi apparatus, trans-Golgi network membrane {ECO 0000269|PubMed 11904301, ECO 0000269|PubMed 11937503, ECO 0000269|PubMed 15525635}; Multi- pass membrane protein {ECO 0000269|PubMed 11904301, ECO 0000269|PubMed 11937503, ECO 0000269|PubMed 15525635}. Note=Perimeter of granules, localizes to the brush border membrane of the enterocyte. Concentrated in early compartments of the secretory pathway such as COPII-coated vesicles. 
# SUBUNIT	Heterooligomer. Interacts with ZNT6. {ECO:0000269|PubMed	15994300}. 
# TCDB	2.A.4.4	the cation diffusion facilitator (cdf) family
# TIGRFAMs	TIGR01297	CDF
# TISSUE SPECIFICITY	ZNT5_HUMAN	Ubiquitously expressed. Highly expressed in pancreas, liver and kidney. Expressed abundantly in insulin- containing beta cells, undetectable in other endocrine cell types including glucagon-secreting alpha cells and most acinar cells. {ECO 0000269|PubMed 11904301, ECO 0000269|PubMed 11937503}. 
# UCSC	uc003jvg	human. [Q8TAD4-1]
# eggNOG	COG1230	LUCA
# eggNOG	KOG1484	Eukaryota
BLAST	swissprot:ZNT5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ZNT5_HUMAN
BioCyc	ZFISH:ENSG00000145740-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000145740-MONOMER
COG	COG1230	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1230
COXPRESdb	64924	http://coxpresdb.jp/data/gene/64924.shtml
CleanEx	HS_SLC30A5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC30A5
DOI	10.1016/j.bcp.2004.05.024	http://dx.doi.org/10.1016/j.bcp.2004.05.024
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1074/jbc.M200577200	http://dx.doi.org/10.1074/jbc.M200577200
DOI	10.1074/jbc.M200910200	http://dx.doi.org/10.1074/jbc.M200910200
DOI	10.1074/jbc.M411247200	http://dx.doi.org/10.1074/jbc.M411247200
DOI	10.1074/jbc.M506902200	http://dx.doi.org/10.1074/jbc.M506902200
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1128/MCB.01298-14	http://dx.doi.org/10.1128/MCB.01298-14
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AC010273	http://www.ebi.ac.uk/ena/data/view/AC010273
EMBL	AF439324	http://www.ebi.ac.uk/ena/data/view/AF439324
EMBL	AF461760	http://www.ebi.ac.uk/ena/data/view/AF461760
EMBL	AK022818	http://www.ebi.ac.uk/ena/data/view/AK022818
EMBL	AK292925	http://www.ebi.ac.uk/ena/data/view/AK292925
EMBL	AY089991	http://www.ebi.ac.uk/ena/data/view/AY089991
EMBL	AY358505	http://www.ebi.ac.uk/ena/data/view/AY358505
EMBL	BC000808	http://www.ebi.ac.uk/ena/data/view/BC000808
EMBL	BC008198	http://www.ebi.ac.uk/ena/data/view/BC008198
EMBL	BC017441	http://www.ebi.ac.uk/ena/data/view/BC017441
EMBL	BC130452	http://www.ebi.ac.uk/ena/data/view/BC130452
EMBL	BC130454	http://www.ebi.ac.uk/ena/data/view/BC130454
EMBL	BC144349	http://www.ebi.ac.uk/ena/data/view/BC144349
EMBL	BX537394	http://www.ebi.ac.uk/ena/data/view/BX537394
EMBL	CH471137	http://www.ebi.ac.uk/ena/data/view/CH471137
EMBL	CH471137	http://www.ebi.ac.uk/ena/data/view/CH471137
Ensembl	ENST00000380860	http://www.ensembl.org/id/ENST00000380860
Ensembl	ENST00000396591	http://www.ensembl.org/id/ENST00000396591
Ensembl	ENST00000502979	http://www.ensembl.org/id/ENST00000502979
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005730
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0030141	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030141
GO_component	GO:0030667	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030667
GO_function	GO:0005385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005385
GO_function	GO:0008270	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270
GO_process	GO:0006824	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006824
GO_process	GO:0006829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006829
GO_process	GO:0006882	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006882
GO_process	GO:0010043	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010043
GO_process	GO:0010155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010155
GO_process	GO:0061088	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061088
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005730
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
Gene3D	1.20.1510.10	http://www.cathdb.info/version/latest/superfamily/1.20.1510.10
GeneCards	SLC30A5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC30A5
GeneID	64924	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64924
GeneTree	ENSGT00630000089781	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00630000089781
HGNC	HGNC:19089	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:19089
HOGENOM	HOG000082502	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000082502&db=HOGENOM6
HOVERGEN	HBG056637	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG056637&db=HOVERGEN
HPA	HPA035373	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035373
InParanoid	Q8TAD4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8TAD4
IntAct	Q8TAD4	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8TAD4*
InterPro	IPR002524	http://www.ebi.ac.uk/interpro/entry/IPR002524
InterPro	IPR027469	http://www.ebi.ac.uk/interpro/entry/IPR027469
Jabion	64924	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=64924
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:64924	http://www.genome.jp/dbget-bin/www_bget?hsa:64924
KEGG_Orthology	KO:K14692	http://www.genome.jp/dbget-bin/www_bget?KO:K14692
MIM	607819	http://www.ncbi.nlm.nih.gov/omim/607819
OMA	ICSVKME	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ICSVKME
OrthoDB	EOG091G030D	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G030D
PANTHER	PTHR11562	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11562
PSORT	swissprot:ZNT5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ZNT5_HUMAN
PSORT-B	swissprot:ZNT5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ZNT5_HUMAN
PSORT2	swissprot:ZNT5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ZNT5_HUMAN
Pfam	PF01545	http://pfam.xfam.org/family/PF01545
PharmGKB	PA134865113	http://www.pharmgkb.org/do/serve?objId=PA134865113&objCls=Gene
Phobius	swissprot:ZNT5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ZNT5_HUMAN
PhylomeDB	Q8TAD4	http://phylomedb.org/?seqid=Q8TAD4
ProteinModelPortal	Q8TAD4	http://www.proteinmodelportal.org/query/uniprot/Q8TAD4
PubMed	11904301	http://www.ncbi.nlm.nih.gov/pubmed/11904301
PubMed	11937503	http://www.ncbi.nlm.nih.gov/pubmed/11937503
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15276077	http://www.ncbi.nlm.nih.gov/pubmed/15276077
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15525635	http://www.ncbi.nlm.nih.gov/pubmed/15525635
PubMed	15994300	http://www.ncbi.nlm.nih.gov/pubmed/15994300
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	25582195	http://www.ncbi.nlm.nih.gov/pubmed/25582195
Reactome	R-HSA-264876	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-264876
Reactome	R-HSA-435368	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-435368
RefSeq	NP_001238898	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001238898
RefSeq	NP_075053	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_075053
RefSeq	NP_076960	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_076960
SMR	Q8TAD4	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8TAD4
STRING	9606.ENSP00000379836	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000379836&targetmode=cogs
STRING	COG1230	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1230&targetmode=cogs
TCDB	2.A.4.4	http://www.tcdb.org/search/result.php?tc=2.A.4.4
TIGRFAMs	TIGR01297	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01297
UCSC	uc003jvg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003jvg&org=rat
UniGene	Hs.631975	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.631975
UniProtKB	ZNT5_HUMAN	http://www.uniprot.org/uniprot/ZNT5_HUMAN
UniProtKB-AC	Q8TAD4	http://www.uniprot.org/uniprot/Q8TAD4
charge	swissprot:ZNT5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ZNT5_HUMAN
eggNOG	COG1230	http://eggnogapi.embl.de/nog_data/html/tree/COG1230
eggNOG	KOG1484	http://eggnogapi.embl.de/nog_data/html/tree/KOG1484
epestfind	swissprot:ZNT5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ZNT5_HUMAN
garnier	swissprot:ZNT5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ZNT5_HUMAN
helixturnhelix	swissprot:ZNT5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZNT5_HUMAN
hmoment	swissprot:ZNT5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ZNT5_HUMAN
iep	swissprot:ZNT5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ZNT5_HUMAN
inforesidue	swissprot:ZNT5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ZNT5_HUMAN
neXtProt	NX_Q8TAD4	http://www.nextprot.org/db/entry/NX_Q8TAD4
octanol	swissprot:ZNT5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ZNT5_HUMAN
pepcoil	swissprot:ZNT5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ZNT5_HUMAN
pepdigest	swissprot:ZNT5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ZNT5_HUMAN
pepinfo	swissprot:ZNT5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ZNT5_HUMAN
pepnet	swissprot:ZNT5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ZNT5_HUMAN
pepstats	swissprot:ZNT5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ZNT5_HUMAN
pepwheel	swissprot:ZNT5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ZNT5_HUMAN
pepwindow	swissprot:ZNT5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ZNT5_HUMAN
sigcleave	swissprot:ZNT5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ZNT5_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CRCM1_HUMAN	Event=Alternative initiation; Named isoforms=2; Name=alpha; IsoId=Q96D31-1; Sequence=Displayed; Name=beta; IsoId=Q96D31-2; Sequence=VSP_044421; 
# AltName	CRCM1_HUMAN	Protein orai-1
# AltName	CRCM1_HUMAN	Transmembrane protein 142A
# BioGrid	124321	3
# DISEASE	CRCM1_HUMAN	Immunodeficiency 9 (IMD9) [MIM 612782]  An immune disorder characterized by recurrent infections, impaired activation and proliferative response of T-cells, decreased T-cell production of cytokines, and normal lymphocytes counts and serum immunoglobulin levels. In surviving patients ectodermal dysplasia with anhidrosis and non-progressive myopathy may be observed. {ECO 0000269|PubMed 16147976, ECO 0000269|PubMed 16582901}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CRCM1_HUMAN	Myopathy, tubular aggregate, 2 (TAM2) [MIM 615883]  A rare congenital myopathy characterized by regular arrays of membrane tubules on muscle biopsies without additional histopathological hallmarks. Tubular aggregates in muscle are structures of variable appearance consisting of an outer tubule containing either one or more microtubule-like structures or amorphous material. TAM2 patients have myopathy and pupillary abnormalities. {ECO 0000269|PubMed 24591628}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000616379	ENSP00000480616; ENSG00000276045
# FUNCTION	CRCM1_HUMAN	Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1 (PubMed 16582901, PubMed 16645049, PubMed 16733527, PubMed 16766533, PubMed 16807233, PubMed 19249086, PubMed 23307288, PubMed 24351972, PubMed 24591628). CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (PubMed 16582901). {ECO 0000269|PubMed 16582901, ECO 0000269|PubMed 16645049, ECO 0000269|PubMed 16733527, ECO 0000269|PubMed 16766533, ECO 0000269|PubMed 16807233, ECO 0000269|PubMed 19249086, ECO 0000269|PubMed 23307288, ECO 0000269|PubMed 24351972, ECO 0000269|PubMed 24591628}. 
# GO_component	GO:0005776	autophagosome; IEA:UniProtKB-SubCell.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0031410	cytoplasmic vesicle; IEA:UniProtKB-KW.
# GO_function	GO:0015279	store-operated calcium channel activity; IDA:UniProtKB.
# GO_process	GO:0002115	store-operated calcium entry; IBA:GO_Central.
# GO_process	GO:0002250	adaptive immune response; IEA:UniProtKB-KW.
# GO_process	GO:0051924	regulation of calcium ion transport; IMP:UniProtKB.
# GO_process	GO:0051928	positive regulation of calcium ion transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005773	vacuole
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q96D31	HS
# HGNC	HGNC:25896	ORAI1
# INTERACTION	CRCM1_HUMAN	Self; NbExp=2; IntAct=EBI-2291476, EBI-2291476; O75185 ATP2C2; NbExp=10; IntAct=EBI-2291476, EBI-2939806; Q9BSW2 CRACR2A; NbExp=6; IntAct=EBI-2291476, EBI-739773; Q9BRQ5 ORAI3; NbExp=3; IntAct=EBI-2291476, EBI-4279484; Q13586 STIM1; NbExp=16; IntAct=EBI-2291476, EBI-448878; 
# IntAct	Q96D31	5
# InterPro	IPR012446	CRAC_channel
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Disease	H00093	[Primary immunodeficiency] CD8 deficiency
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko05340	Primary immunodeficiency
# MIM	610277	gene
# MIM	612782	phenotype
# MIM	615883	phenotype
# MISCELLANEOUS	In Greek mythology, the 'Orai' are the keepers of the gates of heaven	 Eunomia (order or harmony), Dike (justice) and Eirene (peace). 
# Organism	CRCM1_HUMAN	Homo sapiens (Human)
# Orphanet	2593	Tubular aggregate myopathy
# Orphanet	317428	Combined immunodeficiency due to ORAI1 deficiency
# PANTHER	PTHR31501	PTHR31501; 2
# PDB	2MAK	NMR; -; B/D=272-292
# PDB	4EHQ	X-ray; 1.90 A; G=69-88
# PTM	CRCM1_HUMAN	N-glycosylated. {ECO 0000269|PubMed 19249086}. 
# PTM	CRCM1_HUMAN	Ubiquitinated. {ECO 0000269|PubMed 23307288}. 
# Pfam	PF07856	Orai-1
# Proteomes	UP000005640	Unplaced
# Reactome	R-HSA-139853	Elevation of cytosolic Ca2+ levels
# Reactome	R-HSA-5578775	Ion homeostasis
# Reactome	R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
# RecName	CRCM1_HUMAN	Calcium release-activated calcium channel protein 1
# RefSeq	NP_116179	NM_032790.3. [Q96D31-1]
# SEQUENCE CAUTION	Sequence=AAH13386.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI04634.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305}; Sequence=BAB55068.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; 
# SIMILARITY	Belongs to the Orai family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	CRCM1_HUMAN	Cell membrane {ECO 0000269|PubMed 16582901, ECO 0000269|PubMed 16645049, ECO 0000269|PubMed 19249086, ECO 0000269|PubMed 22641696, ECO 0000269|PubMed 23307288, ECO 0000269|PubMed 24351972}; Multi-pass membrane protein {ECO 0000269|PubMed 16582901, ECO 0000269|PubMed 16645049, ECO 0000269|PubMed 19249086, ECO 0000269|PubMed 22641696, ECO 0000269|PubMed 24351972}. Cytoplasmic vesicle, autophagosome {ECO 0000269|PubMed 23307288}. Note=Isoform beta is more mobile in the plasma membrane. Colocalizes with UBQLN1 in the autophagosome. {ECO 0000269|PubMed 23307288}. 
# SUBUNIT	CRCM1_HUMAN	Interacts with STIM1 and STIM2; this regulates channel activity (PubMed 17905723, PubMed 19249086, PubMed 24351972). Interacts with CALM; this may displace STIM1 and STIM2 and might thereby modulate channel activity (PubMed 23109337). Interacts with CRACR2A/EFCAB4B; the interaction is direct and takes place in absence of Ca(2+) (PubMed 20418871). Forms a complex with CRACR2A/EFCAB4B and STIM1 at low concentration of Ca(2+), the complex dissociates at elevated Ca(2+) concentrations. Interacts with ASPH (isoform 8) (PubMed 22586105). Interacts with SLC35G1 (PubMed 22084111). Interacts with UBQLN1 (PubMed 23307288). {ECO 0000269|PubMed 17905723, ECO 0000269|PubMed 19249086, ECO 0000269|PubMed 20418871, ECO 0000269|PubMed 22084111, ECO 0000269|PubMed 22586105, ECO 0000269|PubMed 23109337, ECO 0000269|PubMed 23307288, ECO 0000269|PubMed 24351972}. 
# TCDB	1.A.52.1	the ca(2+) release-activated ca(2+) (crac) channel (crac-c) family
# TopDownProteomics	Q96D31-2	-. [Q96D31-2]
# UCSC	uc031zps	human. [Q96D31-1]
# WEB RESOURCE	CRCM1_HUMAN	Name=ORAI1base; Note=ORAI1 mutation db; URL="http //structure.bmc.lu.se/idbase/ORAI1base/";
# eggNOG	ENOG4110DSB	LUCA
# eggNOG	KOG4298	Eukaryota
BLAST	swissprot:CRCM1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CRCM1_HUMAN
BioCyc	ZFISH:G66-32411-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32411-MONOMER
COXPRESdb	84876	http://coxpresdb.jp/data/gene/84876.shtml
CleanEx	HS_ORAI1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ORAI1
DIP	DIP-46289N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-46289N
DOI	10.1007/s10059-013-2268-7	http://dx.doi.org/10.1007/s10059-013-2268-7
DOI	10.1016/j.cell.2009.02.014	http://dx.doi.org/10.1016/j.cell.2009.02.014
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature04702	http://dx.doi.org/10.1038/nature04702
DOI	10.1038/ncb1435	http://dx.doi.org/10.1038/ncb1435
DOI	10.1038/ncb2045	http://dx.doi.org/10.1038/ncb2045
DOI	10.1038/ncomms3963	http://dx.doi.org/10.1038/ncomms3963
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.1117231108	http://dx.doi.org/10.1073/pnas.1117231108
DOI	10.1073/pnas.1200667109	http://dx.doi.org/10.1073/pnas.1200667109
DOI	10.1073/pnas.1312520111	http://dx.doi.org/10.1073/pnas.1312520111
DOI	10.1074/jbc.C600126200	http://dx.doi.org/10.1074/jbc.C600126200
DOI	10.1074/jbc.M112.380964	http://dx.doi.org/10.1074/jbc.M112.380964
DOI	10.1074/jbc.M604589200	http://dx.doi.org/10.1074/jbc.M604589200
DOI	10.1084/jem.20050687	http://dx.doi.org/10.1084/jem.20050687
DOI	10.1096/fj.07-9449com	http://dx.doi.org/10.1096/fj.07-9449com
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1127883	http://dx.doi.org/10.1126/science.1127883
DOI	10.1242/jcs.104919	http://dx.doi.org/10.1242/jcs.104919
EMBL	AK027372	http://www.ebi.ac.uk/ena/data/view/AK027372
EMBL	BC013386	http://www.ebi.ac.uk/ena/data/view/BC013386
EMBL	BC015369	http://www.ebi.ac.uk/ena/data/view/BC015369
EMBL	BC075831	http://www.ebi.ac.uk/ena/data/view/BC075831
EMBL	BC104633	http://www.ebi.ac.uk/ena/data/view/BC104633
Ensembl	ENST00000616379	http://www.ensembl.org/id/ENST00000616379
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005776	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005776
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GO_function	GO:0015279	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015279
GO_process	GO:0002115	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002115
GO_process	GO:0002250	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002250
GO_process	GO:0051924	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051924
GO_process	GO:0051928	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051928
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005773	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005773
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	ORAI1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ORAI1
GeneID	84876	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84876
HGNC	HGNC:25896	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:25896
HOGENOM	HOG000246925	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000246925&db=HOGENOM6
HOVERGEN	HBG081343	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG081343&db=HOVERGEN
HPA	HPA016583	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA016583
HPA	HPA061823	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA061823
InParanoid	Q96D31	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96D31
IntAct	Q96D31	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96D31*
InterPro	IPR012446	http://www.ebi.ac.uk/interpro/entry/IPR012446
Jabion	84876	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=84876
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Disease	H00093	http://www.genome.jp/dbget-bin/www_bget?H00093
KEGG_Gene	hsa:84876	http://www.genome.jp/dbget-bin/www_bget?hsa:84876
KEGG_Orthology	KO:K16056	http://www.genome.jp/dbget-bin/www_bget?KO:K16056
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko05340	http://www.genome.jp/kegg-bin/show_pathway?ko05340
MIM	610277	http://www.ncbi.nlm.nih.gov/omim/610277
MIM	612782	http://www.ncbi.nlm.nih.gov/omim/612782
MIM	615883	http://www.ncbi.nlm.nih.gov/omim/615883
MINT	MINT-6780078	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6780078
OMA	DAEHDYP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DAEHDYP
Orphanet	2593	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=2593
Orphanet	317428	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=317428
OrthoDB	EOG091G0E4P	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0E4P
PANTHER	PTHR31501	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31501
PDB	2MAK	http://www.ebi.ac.uk/pdbe-srv/view/entry/2MAK
PDB	4EHQ	http://www.ebi.ac.uk/pdbe-srv/view/entry/4EHQ
PDBsum	2MAK	http://www.ebi.ac.uk/pdbsum/2MAK
PDBsum	4EHQ	http://www.ebi.ac.uk/pdbsum/4EHQ
PSORT	swissprot:CRCM1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CRCM1_HUMAN
PSORT-B	swissprot:CRCM1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CRCM1_HUMAN
PSORT2	swissprot:CRCM1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CRCM1_HUMAN
Pfam	PF07856	http://pfam.xfam.org/family/PF07856
PharmGKB	PA162398445	http://www.pharmgkb.org/do/serve?objId=PA162398445&objCls=Gene
Phobius	swissprot:CRCM1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CRCM1_HUMAN
PhylomeDB	Q96D31	http://phylomedb.org/?seqid=Q96D31
ProteinModelPortal	Q96D31	http://www.proteinmodelportal.org/query/uniprot/Q96D31
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16147976	http://www.ncbi.nlm.nih.gov/pubmed/16147976
PubMed	16582901	http://www.ncbi.nlm.nih.gov/pubmed/16582901
PubMed	16645049	http://www.ncbi.nlm.nih.gov/pubmed/16645049
PubMed	16733527	http://www.ncbi.nlm.nih.gov/pubmed/16733527
PubMed	16766533	http://www.ncbi.nlm.nih.gov/pubmed/16766533
PubMed	16807233	http://www.ncbi.nlm.nih.gov/pubmed/16807233
PubMed	17905723	http://www.ncbi.nlm.nih.gov/pubmed/17905723
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19249086	http://www.ncbi.nlm.nih.gov/pubmed/19249086
PubMed	20418871	http://www.ncbi.nlm.nih.gov/pubmed/20418871
PubMed	22084111	http://www.ncbi.nlm.nih.gov/pubmed/22084111
PubMed	22586105	http://www.ncbi.nlm.nih.gov/pubmed/22586105
PubMed	22641696	http://www.ncbi.nlm.nih.gov/pubmed/22641696
PubMed	23109337	http://www.ncbi.nlm.nih.gov/pubmed/23109337
PubMed	23307288	http://www.ncbi.nlm.nih.gov/pubmed/23307288
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	24351972	http://www.ncbi.nlm.nih.gov/pubmed/24351972
PubMed	24591628	http://www.ncbi.nlm.nih.gov/pubmed/24591628
Reactome	R-HSA-139853	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-139853
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
Reactome	R-HSA-983695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983695
RefSeq	NP_116179	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_116179
SMR	Q96D31	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q96D31
STRING	9606.ENSP00000328216	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000328216&targetmode=cogs
TCDB	1.A.52.1	http://www.tcdb.org/search/result.php?tc=1.A.52.1
UCSC	uc031zps	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc031zps&org=rat
UniGene	Hs.55148	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.55148
UniProtKB	CRCM1_HUMAN	http://www.uniprot.org/uniprot/CRCM1_HUMAN
UniProtKB-AC	Q96D31	http://www.uniprot.org/uniprot/Q96D31
charge	swissprot:CRCM1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CRCM1_HUMAN
eggNOG	ENOG4110DSB	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110DSB
eggNOG	KOG4298	http://eggnogapi.embl.de/nog_data/html/tree/KOG4298
epestfind	swissprot:CRCM1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CRCM1_HUMAN
garnier	swissprot:CRCM1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CRCM1_HUMAN
helixturnhelix	swissprot:CRCM1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CRCM1_HUMAN
hmoment	swissprot:CRCM1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CRCM1_HUMAN
iep	swissprot:CRCM1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CRCM1_HUMAN
inforesidue	swissprot:CRCM1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CRCM1_HUMAN
neXtProt	NX_Q96D31	http://www.nextprot.org/db/entry/NX_Q96D31
octanol	swissprot:CRCM1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CRCM1_HUMAN
pepcoil	swissprot:CRCM1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CRCM1_HUMAN
pepdigest	swissprot:CRCM1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CRCM1_HUMAN
pepinfo	swissprot:CRCM1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CRCM1_HUMAN
pepnet	swissprot:CRCM1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CRCM1_HUMAN
pepstats	swissprot:CRCM1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CRCM1_HUMAN
pepwheel	swissprot:CRCM1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CRCM1_HUMAN
pepwindow	swissprot:CRCM1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CRCM1_HUMAN
sigcleave	swissprot:CRCM1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CRCM1_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNH3_HUMAN	Brain-specific eag-like channel 1
# AltName	KCNH3_HUMAN	Ether-a-go-go-like potassium channel 2
# AltName	KCNH3_HUMAN	Voltage-gated potassium channel subunit Kv12.2
# DOMAIN	KCNH3_HUMAN	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. 
# Ensembl	ENST00000257981	ENSP00000257981; ENSG00000135519
# FUNCTION	KCNH3_HUMAN	Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly. 
# GO_component	GO:0005622	intracellular; IEA:GOC.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_function	GO:0000155	phosphorelay sensor kinase activity; IEA:InterPro.
# GO_function	GO:0005249	voltage-gated potassium channel activity; TAS:UniProtKB.
# GO_process	GO:0006813	potassium ion transport; TAS:UniProtKB.
# GO_process	GO:0042391	regulation of membrane potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005622	intracellular
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0016301	kinase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Gene3D	2.60.120.10	-; 1.
# Genevisible	Q9ULD8	HS
# HGNC	HGNC:6252	KCNH3
# INTERACTION	KCNH3_HUMAN	P04578 env (xeno); NbExp=3; IntAct=EBI-8079227, EBI-6163496; 
# InterPro	IPR000014	PAS
# InterPro	IPR000595	cNMP-bd_dom
# InterPro	IPR000700	PAS-assoc_C
# InterPro	IPR001610	PAC
# InterPro	IPR003938	K_chnl_volt-dep_EAG/ELK/ERG
# InterPro	IPR003950	K_chnl_volt-dep_ELK
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR014710	RmlC-like_jellyroll
# InterPro	IPR018490	cNMP-bd-like
# KEGG_Brite	ko04040	Ion channels
# MIM	604527	gene
# Organism	KCNH3_HUMAN	Homo sapiens (Human)
# PRINTS	PR01463	EAGCHANLFMLY
# PRINTS	PR01465	ELKCHANNEL
# PROSITE	PS50042	CNMP_BINDING_3
# PROSITE	PS50112	PAS
# PROSITE	PS50113	PAC
# Pfam	PF00027	cNMP_binding
# Pfam	PF00520	Ion_trans
# Pfam	PF13426	PAS_9
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# RecName	KCNH3_HUMAN	Potassium voltage-gated channel subfamily H member 3
# RefSeq	NP_001300959	NM_001314030.1
# RefSeq	NP_036416	NM_012284.2
# SEQUENCE CAUTION	Sequence=BAA86596.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.2/KCNH3 sub-subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 PAC (PAS-associated C-terminal) domain. {ECO:0000255|PROSITE-ProRule	PRU00141}. 
# SIMILARITY	Contains 1 PAS (PER-ARNT-SIM) domain. {ECO:0000255|PROSITE-ProRule	PRU00140}. 
# SIMILARITY	Contains 1 cyclic nucleotide-binding domain. {ECO:0000255|PROSITE-ProRule	PRU00060}. 
# SMART	SM00086	PAC
# SMART	SM00100	cNMP
# SUBCELLULAR LOCATION	KCNH3_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	KCNH3_HUMAN	The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. 
# SUPFAM	SSF51206	SSF51206
# SUPFAM	SSF55785	SSF55785
# TCDB	1.A.1.20	the voltage-gated ion channel (vic) superfamily
# TIGRFAMs	TIGR00229	sensory_box
# TISSUE SPECIFICITY	KCNH3_HUMAN	Detected only in brain, in particular in the telencephalon. Detected in the cerebral cortex, occipital pole, frontal and temporal lobe, putamen, amygdala, hippocampus and caudate nucleus. 
# UCSC	uc001ruh	human
# eggNOG	ENOG410XPSE	LUCA
# eggNOG	KOG0498	Eukaryota
BLAST	swissprot:KCNH3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNH3_HUMAN
BioCyc	ZFISH:ENSG00000135519-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000135519-MONOMER
COXPRESdb	23416	http://coxpresdb.jp/data/gene/23416.shtml
CleanEx	HS_KCNH3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNH3
DOI	10.1074/jbc.274.35.25018	http://dx.doi.org/10.1074/jbc.274.35.25018
DOI	10.1093/dnares/6.5.337	http://dx.doi.org/10.1093/dnares/6.5.337
EMBL	AB022696	http://www.ebi.ac.uk/ena/data/view/AB022696
EMBL	AB033108	http://www.ebi.ac.uk/ena/data/view/AB033108
Ensembl	ENST00000257981	http://www.ensembl.org/id/ENST00000257981
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0000155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0016301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	2.60.120.10	http://www.cathdb.info/version/latest/superfamily/2.60.120.10
GeneCards	KCNH3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNH3
GeneID	23416	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23416
GeneTree	ENSGT00760000118772	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118772
HGNC	HGNC:6252	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6252
HOGENOM	HOG000230794	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230794&db=HOGENOM6
HOVERGEN	HBG052232	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052232&db=HOVERGEN
HPA	HPA051088	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA051088
InParanoid	Q9ULD8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9ULD8
IntAct	Q9ULD8	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9ULD8*
InterPro	IPR000014	http://www.ebi.ac.uk/interpro/entry/IPR000014
InterPro	IPR000595	http://www.ebi.ac.uk/interpro/entry/IPR000595
InterPro	IPR000700	http://www.ebi.ac.uk/interpro/entry/IPR000700
InterPro	IPR001610	http://www.ebi.ac.uk/interpro/entry/IPR001610
InterPro	IPR003938	http://www.ebi.ac.uk/interpro/entry/IPR003938
InterPro	IPR003950	http://www.ebi.ac.uk/interpro/entry/IPR003950
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR014710	http://www.ebi.ac.uk/interpro/entry/IPR014710
InterPro	IPR018490	http://www.ebi.ac.uk/interpro/entry/IPR018490
Jabion	23416	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=23416
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:23416	http://www.genome.jp/dbget-bin/www_bget?hsa:23416
KEGG_Orthology	KO:K04906	http://www.genome.jp/dbget-bin/www_bget?KO:K04906
MIM	604527	http://www.ncbi.nlm.nih.gov/omim/604527
MINT	MINT-7968644	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-7968644
OMA	PLMAPWP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PLMAPWP
OrthoDB	EOG091G0OXR	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0OXR
PRINTS	PR01463	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01463
PRINTS	PR01465	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01465
PROSITE	PS50042	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50042
PROSITE	PS50112	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50112
PROSITE	PS50113	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50113
PSORT	swissprot:KCNH3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNH3_HUMAN
PSORT-B	swissprot:KCNH3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNH3_HUMAN
PSORT2	swissprot:KCNH3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNH3_HUMAN
Pfam	PF00027	http://pfam.xfam.org/family/PF00027
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF13426	http://pfam.xfam.org/family/PF13426
PharmGKB	PA30038	http://www.pharmgkb.org/do/serve?objId=PA30038&objCls=Gene
Phobius	swissprot:KCNH3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNH3_HUMAN
PhylomeDB	Q9ULD8	http://phylomedb.org/?seqid=Q9ULD8
ProteinModelPortal	Q9ULD8	http://www.proteinmodelportal.org/query/uniprot/Q9ULD8
PubMed	10455180	http://www.ncbi.nlm.nih.gov/pubmed/10455180
PubMed	10574462	http://www.ncbi.nlm.nih.gov/pubmed/10574462
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
RefSeq	NP_001300959	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001300959
RefSeq	NP_036416	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_036416
SMART	SM00086	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00086
SMART	SM00100	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00100
SMR	Q9ULD8	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9ULD8
STRING	9606.ENSP00000257981	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000257981&targetmode=cogs
SUPFAM	SSF51206	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51206
SUPFAM	SSF55785	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55785
TCDB	1.A.1.20	http://www.tcdb.org/search/result.php?tc=1.A.1.20
TIGRFAMs	TIGR00229	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00229
UCSC	uc001ruh	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001ruh&org=rat
UniGene	Hs.64064	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.64064
UniProtKB	KCNH3_HUMAN	http://www.uniprot.org/uniprot/KCNH3_HUMAN
UniProtKB-AC	Q9ULD8	http://www.uniprot.org/uniprot/Q9ULD8
charge	swissprot:KCNH3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNH3_HUMAN
eggNOG	ENOG410XPSE	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPSE
eggNOG	KOG0498	http://eggnogapi.embl.de/nog_data/html/tree/KOG0498
epestfind	swissprot:KCNH3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNH3_HUMAN
garnier	swissprot:KCNH3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNH3_HUMAN
helixturnhelix	swissprot:KCNH3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNH3_HUMAN
hmoment	swissprot:KCNH3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNH3_HUMAN
iep	swissprot:KCNH3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNH3_HUMAN
inforesidue	swissprot:KCNH3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNH3_HUMAN
neXtProt	NX_Q9ULD8	http://www.nextprot.org/db/entry/NX_Q9ULD8
octanol	swissprot:KCNH3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNH3_HUMAN
pepcoil	swissprot:KCNH3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNH3_HUMAN
pepdigest	swissprot:KCNH3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNH3_HUMAN
pepinfo	swissprot:KCNH3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNH3_HUMAN
pepnet	swissprot:KCNH3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNH3_HUMAN
pepstats	swissprot:KCNH3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNH3_HUMAN
pepwheel	swissprot:KCNH3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNH3_HUMAN
pepwindow	swissprot:KCNH3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNH3_HUMAN
sigcleave	swissprot:KCNH3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNH3_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCJ10_HUMAN	ATP-dependent inwardly rectifying potassium channel Kir4.1
# AltName	KCJ10_HUMAN	Inward rectifier K(+) channel Kir1.2
# AltName	KCJ10_HUMAN	Potassium channel, inwardly rectifying subfamily J member 10
# BioGrid	109968	17
# ChiTaRS	KCNJ10	human
# DISEASE	KCJ10_HUMAN	Seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SESAMES) [MIM 612780]  A complex disorder characterized by generalized seizures with onset in infancy, delayed psychomotor development, ataxia, sensorineural hearing loss, hypokalemia, metabolic alkalosis, and hypomagnesemia. {ECO 0000269|PubMed 19289823, ECO 0000269|PubMed 19420365, ECO 0000269|PubMed 22612257, ECO 0000269|PubMed 24561201}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB01392	Yohimbine
# Ensembl	ENST00000368089	ENSP00000357068; ENSG00000177807
# FUNCTION	KCJ10_HUMAN	May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules. {ECO 0000250, ECO 0000305|PubMed 24561201}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0098793	presynapse; IEA:GOC.
# GO_function	GO:0005242	inward rectifier potassium channel activity; TAS:Reactome.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0015272	ATP-activated inward rectifier potassium channel activity; TAS:ProtInc.
# GO_function	GO:0015467	G-protein activated inward rectifier potassium channel activity; TAS:Reactome.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0007601	visual perception; IEA:Ensembl.
# GO_process	GO:0007628	adult walking behavior; IEA:Ensembl.
# GO_process	GO:0010107	potassium ion import; IBA:GO_Central.
# GO_process	GO:0022010	central nervous system myelination; IEA:Ensembl.
# GO_process	GO:0048169	regulation of long-term neuronal synaptic plasticity; IEA:Ensembl.
# GO_process	GO:0051935	glutamate reuptake; IEA:Ensembl.
# GO_process	GO:0055075	potassium ion homeostasis; IEA:Ensembl.
# GO_process	GO:0060075	regulation of resting membrane potential; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.40.1400	-; 1.
# Genevisible	P78508	HS
# HGNC	HGNC:6256	KCNJ10
# INTERACTION	KCJ10_HUMAN	F1PK57 MAGI1 (xeno); NbExp=2; IntAct=EBI-9117877, EBI-9118227; Q8IUQ4 SIAH1; NbExp=3; IntAct=EBI-9117877, EBI-747107; 
# IntAct	P78508	5
# InterPro	IPR003269	K_chnl_inward-rec_Kir1.2
# InterPro	IPR013518	K_chnl_inward-rec_Kir_cyto
# InterPro	IPR014756	Ig_E-set
# InterPro	IPR016449	K_chnl_inward-rec_Kir
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00803	[Nervous system disease; Epilepsy; Mental retardation] SeSAME/EAST syndrome
# KEGG_Pathway	ko04971	Gastric acid secretion
# MIM	602208	gene
# MIM	612780	phenotype
# Organism	KCJ10_HUMAN	Homo sapiens (Human)
# Orphanet	199343	EAST syndrome
# Orphanet	705	Pendred syndrome
# PANTHER	PTHR11767	PTHR11767
# PANTHER	PTHR11767:SF21	PTHR11767:SF21
# PIRSF	PIRSF005465	GIRK_kir
# PRINTS	PR01320	KIRCHANNEL
# PRINTS	PR01322	KIR12CHANNEL
# Pfam	PF01007	IRK
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-1296041	Activation of G protein gated Potassium channels
# Reactome	R-HSA-1296067	Potassium transport channels
# Reactome	R-HSA-997272	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
# RecName	KCJ10_HUMAN	ATP-sensitive inward rectifier potassium channel 10
# RefSeq	NP_002232	NM_002241.4
# SEQUENCE CAUTION	Sequence=AAH34036.2; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ10 subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	KCJ10_HUMAN	Membrane {ECO 0000269|PubMed 24561201}; Multi-pass membrane protein. Basolateral cell membrane {ECO 0000269|PubMed 24561201}. Note=In kidney distal convoluted tubules, located in the basolateral membrane where it colocalizes with KCNJ16. {ECO 0000269|PubMed 24561201}. 
# SUBUNIT	KCJ10_HUMAN	Heterodimer with Kir5.1/KCNJ16; this interaction is required for KCNJ16 localization to the basolateral membrane in kidney cells. Interacts with MAGI1, alone and possibly as a heterodimer with KCNJ16; this interaction may facilitate KCNJ10/KCNJ16 potassium channel expression at the basolateral membrane in kidney cells (PubMed 24561201). Interacts with PATJ (By similarity). {ECO 0000250|UniProtKB Q9JM63, ECO 0000269|PubMed 24561201}. 
# SUPFAM	SSF81296	SSF81296
# TCDB	1.A.2.1.16	inward rectifier k(+) channel (irk-c) family
# TISSUE SPECIFICITY	Expressed in kidney (at protein level). {ECO:0000269|PubMed	24561201}. 
# UCSC	uc001fuw	human
# eggNOG	ENOG410XQ62	LUCA
# eggNOG	KOG3827	Eukaryota
BLAST	swissprot:KCJ10_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCJ10_HUMAN
BioCyc	ZFISH:ENSG00000177807-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000177807-MONOMER
COXPRESdb	3766	http://coxpresdb.jp/data/gene/3766.shtml
CleanEx	HS_KCNJ10	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNJ10
DOI	10.1016/S0898-6568(99)00059-5	http://dx.doi.org/10.1016/S0898-6568(99)00059-5
DOI	10.1016/j.febslet.2014.02.024	http://dx.doi.org/10.1016/j.febslet.2014.02.024
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1056/NEJMoa0810276	http://dx.doi.org/10.1056/NEJMoa0810276
DOI	10.1073/pnas.0901749106	http://dx.doi.org/10.1073/pnas.0901749106
DOI	10.1074/jbc.272.1.586	http://dx.doi.org/10.1074/jbc.272.1.586
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1528-1167.2012.03516.x	http://dx.doi.org/10.1111/j.1528-1167.2012.03516.x
DrugBank	DB01392	http://www.drugbank.ca/drugs/DB01392
EMBL	AL513302	http://www.ebi.ac.uk/ena/data/view/AL513302
EMBL	BC034036	http://www.ebi.ac.uk/ena/data/view/BC034036
EMBL	BC131627	http://www.ebi.ac.uk/ena/data/view/BC131627
EMBL	CH471121	http://www.ebi.ac.uk/ena/data/view/CH471121
EMBL	U52155	http://www.ebi.ac.uk/ena/data/view/U52155
EMBL	U73192	http://www.ebi.ac.uk/ena/data/view/U73192
EMBL	U73193	http://www.ebi.ac.uk/ena/data/view/U73193
Ensembl	ENST00000368089	http://www.ensembl.org/id/ENST00000368089
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0098793	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098793
GO_function	GO:0005242	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005242
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0015272	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015272
GO_function	GO:0015467	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015467
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0007601	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007601
GO_process	GO:0007628	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007628
GO_process	GO:0010107	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010107
GO_process	GO:0022010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022010
GO_process	GO:0048169	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048169
GO_process	GO:0051935	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051935
GO_process	GO:0055075	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055075
GO_process	GO:0060075	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060075
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.40.1400	http://www.cathdb.info/version/latest/superfamily/2.60.40.1400
GeneCards	KCNJ10	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNJ10
GeneID	3766	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3766
GeneTree	ENSGT00760000118842	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118842
HGNC	HGNC:6256	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6256
HOGENOM	HOG000237326	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237326&db=HOGENOM6
HOVERGEN	HBG006178	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006178&db=HOVERGEN
InParanoid	P78508	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P78508
IntAct	P78508	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P78508*
InterPro	IPR003269	http://www.ebi.ac.uk/interpro/entry/IPR003269
InterPro	IPR013518	http://www.ebi.ac.uk/interpro/entry/IPR013518
InterPro	IPR014756	http://www.ebi.ac.uk/interpro/entry/IPR014756
InterPro	IPR016449	http://www.ebi.ac.uk/interpro/entry/IPR016449
Jabion	3766	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3766
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00803	http://www.genome.jp/dbget-bin/www_bget?H00803
KEGG_Gene	hsa:3766	http://www.genome.jp/dbget-bin/www_bget?hsa:3766
KEGG_Orthology	KO:K05003	http://www.genome.jp/dbget-bin/www_bget?KO:K05003
KEGG_Pathway	ko04971	http://www.genome.jp/kegg-bin/show_pathway?ko04971
MIM	602208	http://www.ncbi.nlm.nih.gov/omim/602208
MIM	612780	http://www.ncbi.nlm.nih.gov/omim/612780
OMA	GTWFAFG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GTWFAFG
Orphanet	199343	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=199343
Orphanet	705	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=705
OrthoDB	EOG091G08HC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08HC
PANTHER	PTHR11767	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11767
PANTHER	PTHR11767:SF21	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11767:SF21
PRINTS	PR01320	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01320
PRINTS	PR01322	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01322
PSORT	swissprot:KCJ10_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCJ10_HUMAN
PSORT-B	swissprot:KCJ10_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCJ10_HUMAN
PSORT2	swissprot:KCJ10_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCJ10_HUMAN
Pfam	PF01007	http://pfam.xfam.org/family/PF01007
PharmGKB	PA30043	http://www.pharmgkb.org/do/serve?objId=PA30043&objCls=Gene
Phobius	swissprot:KCJ10_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCJ10_HUMAN
PhylomeDB	P78508	http://phylomedb.org/?seqid=P78508
ProteinModelPortal	P78508	http://www.proteinmodelportal.org/query/uniprot/P78508
PubMed	10659995	http://www.ncbi.nlm.nih.gov/pubmed/10659995
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	19289823	http://www.ncbi.nlm.nih.gov/pubmed/19289823
PubMed	19420365	http://www.ncbi.nlm.nih.gov/pubmed/19420365
PubMed	22612257	http://www.ncbi.nlm.nih.gov/pubmed/22612257
PubMed	24561201	http://www.ncbi.nlm.nih.gov/pubmed/24561201
PubMed	8995301	http://www.ncbi.nlm.nih.gov/pubmed/8995301
Reactome	R-HSA-1296041	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296041
Reactome	R-HSA-1296067	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296067
Reactome	R-HSA-997272	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-997272
RefSeq	NP_002232	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002232
SMR	P78508	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P78508
STRING	9606.ENSP00000357068	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000357068&targetmode=cogs
SUPFAM	SSF81296	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81296
TCDB	1.A.2.1.16	http://www.tcdb.org/search/result.php?tc=1.A.2.1.16
UCSC	uc001fuw	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001fuw&org=rat
UniGene	Hs.408960	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.408960
UniProtKB	KCJ10_HUMAN	http://www.uniprot.org/uniprot/KCJ10_HUMAN
UniProtKB-AC	P78508	http://www.uniprot.org/uniprot/P78508
charge	swissprot:KCJ10_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCJ10_HUMAN
eggNOG	ENOG410XQ62	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ62
eggNOG	KOG3827	http://eggnogapi.embl.de/nog_data/html/tree/KOG3827
epestfind	swissprot:KCJ10_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCJ10_HUMAN
garnier	swissprot:KCJ10_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCJ10_HUMAN
helixturnhelix	swissprot:KCJ10_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCJ10_HUMAN
hmoment	swissprot:KCJ10_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCJ10_HUMAN
iep	swissprot:KCJ10_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCJ10_HUMAN
inforesidue	swissprot:KCJ10_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCJ10_HUMAN
neXtProt	NX_P78508	http://www.nextprot.org/db/entry/NX_P78508
octanol	swissprot:KCJ10_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCJ10_HUMAN
pepcoil	swissprot:KCJ10_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCJ10_HUMAN
pepdigest	swissprot:KCJ10_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCJ10_HUMAN
pepinfo	swissprot:KCJ10_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCJ10_HUMAN
pepnet	swissprot:KCJ10_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCJ10_HUMAN
pepstats	swissprot:KCJ10_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCJ10_HUMAN
pepwheel	swissprot:KCJ10_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCJ10_HUMAN
pepwindow	swissprot:KCJ10_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCJ10_HUMAN
sigcleave	swissprot:KCJ10_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCJ10_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CAHM3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q86XJ0-1; Sequence=Displayed; Name=2; IsoId=Q86XJ0-2; Sequence=VSP_014318; Note=No experimental confirmation available.; 
# AltName	CAHM3_HUMAN	Protein FAM26A
# CCDS	CCDS44476	-. [Q86XJ0-2]
# Ensembl	ENST00000369783	ENSP00000358798; ENSG00000183128. [Q86XJ0-2]
# FUNCTION	CAHM3_HUMAN	Pore-forming subunit of a voltage-gated ion channel. {ECO 0000250}. 
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0005261	cation channel activity; IBA:GO_Central.
# GO_process	GO:0034220	ion transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q86XJ0	HS
# HGNC	HGNC:23458	CALHM3
# InterPro	IPR029569	FAM26
# InterPro	IPR029571	CALHM3
# Organism	CAHM3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR32261	PTHR32261; 2
# PANTHER	PTHR32261:SF7	PTHR32261:SF7; 2
# Pfam	PF14798	Ca_hom_mod
# Proteomes	UP000005640	Chromosome 10
# RecName	CAHM3_HUMAN	Calcium homeostasis modulator protein 3
# RefSeq	NP_001123214	NM_001129742.1. [Q86XJ0-2]
# SIMILARITY	Belongs to the FAM26 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	CAHM3_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	1.A.84.1	the calcium homeostasis modulator ca(2+) channel (calhm-c) family
# TISSUE SPECIFICITY	Specifically expressed in circumvallate taste bud cells. {ECO:0000269|PubMed	19997627}. 
# UCSC	uc001kxg	human. [Q86XJ0-1]
# eggNOG	ENOG410IJU4	Eukaryota
# eggNOG	ENOG4110PIK	LUCA
BLAST	swissprot:CAHM3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CAHM3_HUMAN
BioCyc	ZFISH:G66-33738-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33738-MONOMER
COXPRESdb	119395	http://coxpresdb.jp/data/gene/119395.shtml
CleanEx	HS_CALHM3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CALHM3
DOI	10.1016/j.cell.2008.05.048	http://dx.doi.org/10.1016/j.cell.2008.05.048
DOI	10.1038/nature02462	http://dx.doi.org/10.1038/nature02462
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1371/journal.pone.0007682	http://dx.doi.org/10.1371/journal.pone.0007682
EMBL	AL139339	http://www.ebi.ac.uk/ena/data/view/AL139339
EMBL	BC039499	http://www.ebi.ac.uk/ena/data/view/BC039499
EMBL	BC043367	http://www.ebi.ac.uk/ena/data/view/BC043367
Ensembl	ENST00000369783	http://www.ensembl.org/id/ENST00000369783
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005261	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005261
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	CALHM3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CALHM3
GeneID	119395	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=119395
GeneTree	ENSGT00530000062796	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062796
H-InvDB	HIX0025951	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0025951
HGNC	HGNC:23458	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:23458
HOGENOM	HOG000111295	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000111295&db=HOGENOM6
HOVERGEN	HBG096020	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG096020&db=HOVERGEN
HPA	HPA018205	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA018205
InParanoid	Q86XJ0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q86XJ0
InterPro	IPR029569	http://www.ebi.ac.uk/interpro/entry/IPR029569
InterPro	IPR029571	http://www.ebi.ac.uk/interpro/entry/IPR029571
Jabion	119395	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=119395
KEGG_Gene	hsa:119395	http://www.genome.jp/dbget-bin/www_bget?hsa:119395
OMA	SGKAHLR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SGKAHLR
OrthoDB	EOG091G09L8	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G09L8
PANTHER	PTHR32261	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32261
PANTHER	PTHR32261:SF7	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32261:SF7
PSORT	swissprot:CAHM3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CAHM3_HUMAN
PSORT-B	swissprot:CAHM3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CAHM3_HUMAN
PSORT2	swissprot:CAHM3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CAHM3_HUMAN
Pfam	PF14798	http://pfam.xfam.org/family/PF14798
PharmGKB	PA162380976	http://www.pharmgkb.org/do/serve?objId=PA162380976&objCls=Gene
Phobius	swissprot:CAHM3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CAHM3_HUMAN
PhylomeDB	Q86XJ0	http://phylomedb.org/?seqid=Q86XJ0
ProteinModelPortal	Q86XJ0	http://www.proteinmodelportal.org/query/uniprot/Q86XJ0
PubMed	15164054	http://www.ncbi.nlm.nih.gov/pubmed/15164054
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18585350	http://www.ncbi.nlm.nih.gov/pubmed/18585350
PubMed	19997627	http://www.ncbi.nlm.nih.gov/pubmed/19997627
RefSeq	NP_001123214	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001123214
SMR	Q86XJ0	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q86XJ0
STRING	9606.ENSP00000358798	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000358798&targetmode=cogs
TCDB	1.A.84.1	http://www.tcdb.org/search/result.php?tc=1.A.84.1
UCSC	uc001kxg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001kxg&org=rat
UniGene	Hs.364624	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.364624
UniProtKB	CAHM3_HUMAN	http://www.uniprot.org/uniprot/CAHM3_HUMAN
UniProtKB-AC	Q86XJ0	http://www.uniprot.org/uniprot/Q86XJ0
charge	swissprot:CAHM3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CAHM3_HUMAN
eggNOG	ENOG410IJU4	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IJU4
eggNOG	ENOG4110PIK	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110PIK
epestfind	swissprot:CAHM3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CAHM3_HUMAN
garnier	swissprot:CAHM3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CAHM3_HUMAN
helixturnhelix	swissprot:CAHM3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CAHM3_HUMAN
hmoment	swissprot:CAHM3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CAHM3_HUMAN
iep	swissprot:CAHM3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CAHM3_HUMAN
inforesidue	swissprot:CAHM3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CAHM3_HUMAN
neXtProt	NX_Q86XJ0	http://www.nextprot.org/db/entry/NX_Q86XJ0
octanol	swissprot:CAHM3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CAHM3_HUMAN
pepcoil	swissprot:CAHM3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CAHM3_HUMAN
pepdigest	swissprot:CAHM3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CAHM3_HUMAN
pepinfo	swissprot:CAHM3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CAHM3_HUMAN
pepnet	swissprot:CAHM3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CAHM3_HUMAN
pepstats	swissprot:CAHM3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CAHM3_HUMAN
pepwheel	swissprot:CAHM3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CAHM3_HUMAN
pepwindow	swissprot:CAHM3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CAHM3_HUMAN
sigcleave	swissprot:CAHM3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CAHM3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	IPO4_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8TEX9-1; Sequence=Displayed; Name=2; IsoId=Q8TEX9-2; Sequence=VSP_009339; Note=No experimental confirmation available.; 
# AltName	IPO4_HUMAN	Importin-4b
# AltName	IPO4_HUMAN	Ran-binding protein 4
# BioGrid	122828	70
# CCDS	CCDS9616	-. [Q8TEX9-1]
# ChiTaRS	IPO4	human
# Ensembl	ENST00000354464	ENSP00000346453; ENSG00000196497. [Q8TEX9-1]
# ExpressionAtlas	Q8TEX9	baseline and differential
# FUNCTION	IPO4_HUMAN	Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. {ECO 0000250, ECO 0000269|PubMed 11823430}. 
# GO_component	GO:0000790	nuclear chromatin; IDA:UniProtKB.
# GO_component	GO:0005737	cytoplasm; IBA:GO_Central.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0031965	nuclear membrane; IBA:GO_Central.
# GO_component	GO:0034399	nuclear periphery; IBA:GO_Central.
# GO_component	GO:0043234	protein complex; IDA:UniProtKB.
# GO_function	GO:0008139	nuclear localization sequence binding; IBA:GO_Central.
# GO_function	GO:0008565	protein transporter activity; IBA:GO_Central.
# GO_process	GO:0000059	protein import into nucleus, docking; IBA:GO_Central.
# GO_process	GO:0000060	protein import into nucleus, translocation; IBA:GO_Central.
# GO_process	GO:0006335	DNA replication-dependent nucleosome assembly; IDA:UniProtKB.
# GO_process	GO:0006336	DNA replication-independent nucleosome assembly; IDA:UniProtKB.
# GO_process	GO:0006607	NLS-bearing protein import into nucleus; IBA:GO_Central.
# GO_process	GO:0006610	ribosomal protein import into nucleus; IBA:GO_Central.
# GO_process	GO:0015031	protein transport; NAS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# GOslim_process	GO:0065003	macromolecular complex assembly
# Gene3D	1.25.10.10	-; 3.
# Genevisible	Q8TEX9	HS
# HGNC	HGNC:19426	IPO4
# IntAct	Q8TEX9	31
# InterPro	IPR000357	HEAT
# InterPro	IPR001494	Importin-beta_N
# InterPro	IPR011989	ARM-like
# InterPro	IPR016024	ARM-type_fold
# InterPro	IPR021133	HEAT_type_2
# Organism	IPO4_HUMAN	Homo sapiens (Human)
# PROSITE	PS50077	HEAT_REPEAT; 2
# PROSITE	PS50166	IMPORTIN_B_NT
# Pfam	PF02985	HEAT
# Pfam	PF03810	IBN_N
# Proteomes	UP000005640	Chromosome 14
# RecName	IPO4_HUMAN	Importin-4
# RefSeq	NP_078934	NM_024658.3. [Q8TEX9-1]
# SEQUENCE CAUTION	IPO4_HUMAN	Sequence=BAB15616.1; Type=Frameshift; Positions=234; Evidence={ECO 0000305}; Sequence=BAB55421.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=BAC11174.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=CAD62595.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305};
# SIMILARITY	Belongs to the importin beta family. {ECO	0000305}. 
# SIMILARITY	Contains 1 importin N-terminal domain. {ECO:0000255|PROSITE-ProRule	PRU00115}. 
# SIMILARITY	Contains 6 HEAT repeats. {ECO:0000255|PROSITE- ProRule	PRU00103}. 
# SMART	SM00913	IBN_N
# SUBCELLULAR LOCATION	IPO4_HUMAN	Cytoplasm {ECO 0000250}. Nucleus {ECO 0000250}. 
# SUBUNIT	Binds with high affinity to RPS3A. The binding is coupled to RanGTP cycles. Binds to human cytomegalovirus UL84. Found in a cytosolic complex with ASF1A, ASF1B, CDAN1 and histones H3.1 and H4. {ECO:0000269|PubMed	22407294}. 
# SUPFAM	SSF48371	SSF48371; 2
# TCDB	1.I.1.1	the nuclear pore complex (npc) family
# UCSC	uc001wmv	human. [Q8TEX9-1]
# eggNOG	ENOG410IQKY	Eukaryota
# eggNOG	ENOG410XP2Z	LUCA
BLAST	swissprot:IPO4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:IPO4_HUMAN
COXPRESdb	79711	http://coxpresdb.jp/data/gene/79711.shtml
CleanEx	HS_IPO4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_IPO4
DIP	DIP-32944N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-32944N
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1038/emboj.2012.55	http://dx.doi.org/10.1038/emboj.2012.55
DOI	10.1038/nature01348	http://dx.doi.org/10.1038/nature01348
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1074/mcp.M111.015131	http://dx.doi.org/10.1074/mcp.M111.015131
DOI	10.1093/emboj/21.3.377	http://dx.doi.org/10.1093/emboj/21.3.377
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1128/JVI.77.6.3734-3748.2003	http://dx.doi.org/10.1128/JVI.77.6.3734-3748.2003
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF411122	http://www.ebi.ac.uk/ena/data/view/AF411122
EMBL	AK026991	http://www.ebi.ac.uk/ena/data/view/AK026991
EMBL	AK027871	http://www.ebi.ac.uk/ena/data/view/AK027871
EMBL	AK074743	http://www.ebi.ac.uk/ena/data/view/AK074743
EMBL	AL136295	http://www.ebi.ac.uk/ena/data/view/AL136295
EMBL	BC003690	http://www.ebi.ac.uk/ena/data/view/BC003690
EMBL	BC110804	http://www.ebi.ac.uk/ena/data/view/BC110804
EMBL	BC136759	http://www.ebi.ac.uk/ena/data/view/BC136759
EMBL	BX248267	http://www.ebi.ac.uk/ena/data/view/BX248267
EMBL	CH471078	http://www.ebi.ac.uk/ena/data/view/CH471078
Ensembl	ENST00000354464	http://www.ensembl.org/id/ENST00000354464
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000790
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0031965	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031965
GO_component	GO:0034399	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034399
GO_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GO_function	GO:0008139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008139
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0000059	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000059
GO_process	GO:0000060	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000060
GO_process	GO:0006335	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006335
GO_process	GO:0006336	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006336
GO_process	GO:0006607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006607
GO_process	GO:0006610	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006610
GO_process	GO:0015031	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
GOslim_process	GO:0065003	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0065003
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
GeneCards	IPO4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=IPO4
GeneID	79711	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79711
GeneTree	ENSGT00550000075074	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000075074
HGNC	HGNC:19426	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:19426
HOVERGEN	HBG049052	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG049052&db=HOVERGEN
HPA	HPA039043	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA039043
HPA	HPA039044	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA039044
InParanoid	Q8TEX9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8TEX9
IntAct	Q8TEX9	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8TEX9*
InterPro	IPR000357	http://www.ebi.ac.uk/interpro/entry/IPR000357
InterPro	IPR001494	http://www.ebi.ac.uk/interpro/entry/IPR001494
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
InterPro	IPR021133	http://www.ebi.ac.uk/interpro/entry/IPR021133
Jabion	79711	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=79711
KEGG_Gene	hsa:79711	http://www.genome.jp/dbget-bin/www_bget?hsa:79711
MINT	MINT-3045897	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3045897
OMA	RPAQEYF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RPAQEYF
OrthoDB	EOG091G012W	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G012W
PROSITE	PS50077	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50077
PROSITE	PS50166	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50166
PSORT	swissprot:IPO4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:IPO4_HUMAN
PSORT-B	swissprot:IPO4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:IPO4_HUMAN
PSORT2	swissprot:IPO4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:IPO4_HUMAN
Pfam	PF02985	http://pfam.xfam.org/family/PF02985
Pfam	PF03810	http://pfam.xfam.org/family/PF03810
PharmGKB	PA134968932	http://www.pharmgkb.org/do/serve?objId=PA134968932&objCls=Gene
Phobius	swissprot:IPO4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:IPO4_HUMAN
PhylomeDB	Q8TEX9	http://phylomedb.org/?seqid=Q8TEX9
ProteinModelPortal	Q8TEX9	http://www.proteinmodelportal.org/query/uniprot/Q8TEX9
PubMed	11823430	http://www.ncbi.nlm.nih.gov/pubmed/11823430
PubMed	12508121	http://www.ncbi.nlm.nih.gov/pubmed/12508121
PubMed	12610148	http://www.ncbi.nlm.nih.gov/pubmed/12610148
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22223895	http://www.ncbi.nlm.nih.gov/pubmed/22223895
PubMed	22407294	http://www.ncbi.nlm.nih.gov/pubmed/22407294
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
RefSeq	NP_078934	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_078934
SMART	SM00913	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00913
SMR	Q8TEX9	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8TEX9
STRING	9606.ENSP00000346453	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000346453&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
TCDB	1.I.1.1	http://www.tcdb.org/search/result.php?tc=1.I.1.1
UCSC	uc001wmv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001wmv&org=rat
UniGene	Hs.411865	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.411865
UniProtKB	IPO4_HUMAN	http://www.uniprot.org/uniprot/IPO4_HUMAN
UniProtKB-AC	Q8TEX9	http://www.uniprot.org/uniprot/Q8TEX9
charge	swissprot:IPO4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:IPO4_HUMAN
eggNOG	ENOG410IQKY	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IQKY
eggNOG	ENOG410XP2Z	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XP2Z
epestfind	swissprot:IPO4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:IPO4_HUMAN
garnier	swissprot:IPO4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:IPO4_HUMAN
helixturnhelix	swissprot:IPO4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:IPO4_HUMAN
hmoment	swissprot:IPO4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:IPO4_HUMAN
iep	swissprot:IPO4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:IPO4_HUMAN
inforesidue	swissprot:IPO4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:IPO4_HUMAN
neXtProt	NX_Q8TEX9	http://www.nextprot.org/db/entry/NX_Q8TEX9
octanol	swissprot:IPO4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:IPO4_HUMAN
pepcoil	swissprot:IPO4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:IPO4_HUMAN
pepdigest	swissprot:IPO4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:IPO4_HUMAN
pepinfo	swissprot:IPO4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:IPO4_HUMAN
pepnet	swissprot:IPO4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:IPO4_HUMAN
pepstats	swissprot:IPO4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:IPO4_HUMAN
pepwheel	swissprot:IPO4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:IPO4_HUMAN
pepwindow	swissprot:IPO4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:IPO4_HUMAN
sigcleave	swissprot:IPO4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:IPO4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S35D1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NTN3-1; Sequence=Displayed; Name=2; IsoId=Q9NTN3-2; Sequence=VSP_056860, VSP_056861; Note=No experimental confirmation available.; 
# AltName	S35D1_HUMAN	Solute carrier family 35 member D1
# AltName	S35D1_HUMAN	UDP-galactose transporter-related protein 7
# CCDS	CCDS636	-. [Q9NTN3-1]
# ChiTaRS	SLC35D1	human
# DISEASE	S35D1_HUMAN	Schneckenbecken dysplasia (SCHBCKD) [MIM 269250]  Rare, autosomal recessive, lethal short-limbed skeletal dysplasia with platyspondylia. {ECO 0000269|PubMed 17952091}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000235345	ENSP00000235345; ENSG00000116704. [Q9NTN3-1]
# FUNCTION	S35D1_HUMAN	Transports both UDP-glucuronic acid (UDP-GlcA) and UDP- N-acetylgalactosamine (UDP-GalNAc) from the cytoplasm to into the endoplasmic reticulum lumen. May participate in glucuronidation and/or chondroitin sulfate biosynthesis. 
# GO_component	GO:0005789	endoplasmic reticulum membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005461	UDP-glucuronic acid transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0006065	UDP-glucuronate biosynthetic process; TAS:Reactome.
# GO_process	GO:0008643	carbohydrate transport; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# Genevisible	Q9NTN3	HS
# HGNC	HGNC:20800	SLC35D1
# InterPro	IPR004853	Sugar_P_trans_dom
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H00474	[Skeletal dysplasia] Schneckenbecken dysplasia
# MIM	269250	phenotype
# MIM	610804	gene
# Organism	S35D1_HUMAN	Homo sapiens (Human)
# Orphanet	3144	Schneckenbecken dysplasia
# Pfam	PF03151	TPT
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-173599	Formation of the active cofactor, UDP-glucuronate
# Reactome	R-HSA-727802	Transport of nucleotide sugars
# RecName	S35D1_HUMAN	UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter
# RefSeq	NP_055954	NM_015139.2. [Q9NTN3-1]
# SEQUENCE CAUTION	Sequence=BAA13390.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the TPT transporter family. SLC35D subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S35D1_HUMAN	Endoplasmic reticulum membrane; Multi-pass membrane protein. 
# TCDB	2.A.7.15	the drug/metabolite transporter (dmt) superfamily
# TISSUE SPECIFICITY	S35D1_HUMAN	Ubiquitous. 
# UCSC	uc001ddk	human. [Q9NTN3-1]
# eggNOG	COG5070	LUCA
# eggNOG	KOG1444	Eukaryota
BLAST	swissprot:S35D1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S35D1_HUMAN
BioCyc	ZFISH:ENSG00000116704-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000116704-MONOMER
COXPRESdb	23169	http://coxpresdb.jp/data/gene/23169.shtml
CleanEx	HS_SLC35D1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC35D1
DOI	10.1016/S0014-5793(01)02358-4	http://dx.doi.org/10.1016/S0014-5793(01)02358-4
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/nm1655	http://dx.doi.org/10.1038/nm1655
DOI	10.1093/dnares/3.5.321	http://dx.doi.org/10.1093/dnares/3.5.321
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB044343	http://www.ebi.ac.uk/ena/data/view/AB044343
EMBL	AK289800	http://www.ebi.ac.uk/ena/data/view/AK289800
EMBL	AK296449	http://www.ebi.ac.uk/ena/data/view/AK296449
EMBL	AL133320	http://www.ebi.ac.uk/ena/data/view/AL133320
EMBL	BC093786	http://www.ebi.ac.uk/ena/data/view/BC093786
EMBL	BC112031	http://www.ebi.ac.uk/ena/data/view/BC112031
EMBL	D87449	http://www.ebi.ac.uk/ena/data/view/D87449
Ensembl	ENST00000235345	http://www.ensembl.org/id/ENST00000235345
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005461
GO_function	GO:0015165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015165
GO_process	GO:0006065	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006065
GO_process	GO:0008643	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008643
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GeneCards	SLC35D1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC35D1
GeneID	23169	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23169
GeneTree	ENSGT00390000014204	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000014204
HGNC	HGNC:20800	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20800
HOGENOM	HOG000038339	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000038339&db=HOGENOM6
HOVERGEN	HBG054071	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054071&db=HOVERGEN
InParanoid	Q9NTN3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NTN3
InterPro	IPR004853	http://www.ebi.ac.uk/interpro/entry/IPR004853
Jabion	23169	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=23169
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00474	http://www.genome.jp/dbget-bin/www_bget?H00474
KEGG_Gene	hsa:23169	http://www.genome.jp/dbget-bin/www_bget?hsa:23169
KEGG_Orthology	KO:K15281	http://www.genome.jp/dbget-bin/www_bget?KO:K15281
MIM	269250	http://www.ncbi.nlm.nih.gov/omim/269250
MIM	610804	http://www.ncbi.nlm.nih.gov/omim/610804
OMA	KFSRPVQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KFSRPVQ
Orphanet	3144	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=3144
OrthoDB	EOG091G0KCU	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0KCU
PSORT	swissprot:S35D1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S35D1_HUMAN
PSORT-B	swissprot:S35D1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S35D1_HUMAN
PSORT2	swissprot:S35D1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S35D1_HUMAN
Pfam	PF03151	http://pfam.xfam.org/family/PF03151
PharmGKB	PA134978757	http://www.pharmgkb.org/do/serve?objId=PA134978757&objCls=Gene
Phobius	swissprot:S35D1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S35D1_HUMAN
PhylomeDB	Q9NTN3	http://phylomedb.org/?seqid=Q9NTN3
ProteinModelPortal	Q9NTN3	http://www.proteinmodelportal.org/query/uniprot/Q9NTN3
PubMed	11322953	http://www.ncbi.nlm.nih.gov/pubmed/11322953
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17952091	http://www.ncbi.nlm.nih.gov/pubmed/17952091
PubMed	9039502	http://www.ncbi.nlm.nih.gov/pubmed/9039502
Reactome	R-HSA-173599	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-173599
Reactome	R-HSA-727802	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-727802
RefSeq	NP_055954	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055954
STRING	9606.ENSP00000235345	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000235345&targetmode=cogs
TCDB	2.A.7.15	http://www.tcdb.org/search/result.php?tc=2.A.7.15
UCSC	uc001ddk	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001ddk&org=rat
UniGene	Hs.213642	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.213642
UniProtKB	S35D1_HUMAN	http://www.uniprot.org/uniprot/S35D1_HUMAN
UniProtKB-AC	Q9NTN3	http://www.uniprot.org/uniprot/Q9NTN3
charge	swissprot:S35D1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S35D1_HUMAN
eggNOG	COG5070	http://eggnogapi.embl.de/nog_data/html/tree/COG5070
eggNOG	KOG1444	http://eggnogapi.embl.de/nog_data/html/tree/KOG1444
epestfind	swissprot:S35D1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S35D1_HUMAN
garnier	swissprot:S35D1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S35D1_HUMAN
helixturnhelix	swissprot:S35D1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S35D1_HUMAN
hmoment	swissprot:S35D1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S35D1_HUMAN
iep	swissprot:S35D1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S35D1_HUMAN
inforesidue	swissprot:S35D1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S35D1_HUMAN
neXtProt	NX_Q9NTN3	http://www.nextprot.org/db/entry/NX_Q9NTN3
octanol	swissprot:S35D1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S35D1_HUMAN
pepcoil	swissprot:S35D1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S35D1_HUMAN
pepdigest	swissprot:S35D1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S35D1_HUMAN
pepinfo	swissprot:S35D1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S35D1_HUMAN
pepnet	swissprot:S35D1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S35D1_HUMAN
pepstats	swissprot:S35D1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S35D1_HUMAN
pepwheel	swissprot:S35D1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S35D1_HUMAN
pepwindow	swissprot:S35D1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S35D1_HUMAN
sigcleave	swissprot:S35D1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S35D1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ATPG_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=Liver; Synonyms=L; IsoId=P36542-1; Sequence=Displayed; Name=Heart; Synonyms=H; IsoId=P36542-2; Sequence=VSP_000439; 
# AltName	ATPG_HUMAN	F-ATPase gamma subunit
# BioGrid	106997	114
# CCDS	CCDS31142	-. [P36542-1]
# CCDS	CCDS7081	-. [P36542-2]
# CDD	cd12151	F1-ATPase_gamma
# ChiTaRS	ATP5C1	human
# Ensembl	ENST00000335698	ENSP00000338568; ENSG00000165629. [P36542-2]
# Ensembl	ENST00000356708	ENSP00000349142; ENSG00000165629. [P36542-1]
# FUNCTION	ATPG_HUMAN	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. 
# GO_component	GO:0000275	mitochondrial proton-transporting ATP synthase complex, catalytic core F(1); NAS:UniProtKB.
# GO_component	GO:0005739	mitochondrion; ISS:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; ISS:UniProtKB.
# GO_component	GO:0005753	mitochondrial proton-transporting ATP synthase complex; IDA:UniProtKB.
# GO_component	GO:0005759	mitochondrial matrix; TAS:Reactome.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0043209	myelin sheath; IEA:Ensembl.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0022857	transmembrane transporter activity; IC:UniProtKB.
# GO_function	GO:0044822	poly(A) RNA binding; IDA:UniProtKB.
# GO_function	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism; IEA:InterPro.
# GO_process	GO:0006119	oxidative phosphorylation; NAS:UniProtKB.
# GO_process	GO:0006754	ATP biosynthetic process; NAS:UniProtKB.
# GO_process	GO:0042776	mitochondrial ATP synthesis coupled proton transport; IC:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003723	RNA binding
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P36542	HS
# HGNC	HGNC:833	ATP5C1
# IntAct	P36542	47
# InterPro	IPR000131	ATP_synth_F1_gsu
# InterPro	IPR023632	ATP_synth_F1_gsu_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	108729	gene
# Organism	ATPG_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11693	PTHR11693
# PIR	A49108	A49108
# PRINTS	PR00126	ATPASEGAMMA
# PROSITE	PS00153	ATPASE_GAMMA
# Pfam	PF00231	ATP-synt
# Proteomes	UP000005640	Chromosome 10
# Reactome	R-HSA-163210	Formation of ATP by chemiosmotic coupling
# RecName	ATPG_HUMAN	ATP synthase subunit gamma, mitochondrial
# RefSeq	NP_001001973	NM_001001973.2. [P36542-1]
# RefSeq	NP_005165	NM_005174.3. [P36542-2]
# SIMILARITY	Belongs to the ATPase gamma chain family. {ECO	0000305}.
# SUBCELLULAR LOCATION	ATPG_HUMAN	Mitochondrion. Mitochondrion inner membrane {ECO 0000250}; Peripheral membrane protein {ECO 0000250}. 
# SUBUNIT	F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits	 a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity). {ECO:0000250}. 
# SUPFAM	SSF52943	SSF52943
# TIGRFAMs	TIGR01146	ATPsyn_F1gamma
# TISSUE SPECIFICITY	ATPG_HUMAN	Isoform Heart is expressed specifically in the heart and skeletal muscle, which require rapid energy supply. Isoform Liver is expressed in the brain, liver and kidney. Isoform Heart and Isoform Liver are expressed in the skin, intestine, stomach and aorta. 
# TopDownProteomics	P36542-1	-. [P36542-1]
# TopDownProteomics	P36542-2	-. [P36542-2]
# UCSC	uc001iju	human. [P36542-1]
# eggNOG	COG0224	LUCA
# eggNOG	KOG1531	Eukaryota
BLAST	swissprot:ATPG_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ATPG_HUMAN
BioCyc	ZFISH:HS09257-MONOMER	http://biocyc.org/getid?id=ZFISH:HS09257-MONOMER
COG	COG0224	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0224
COXPRESdb	509	http://coxpresdb.jp/data/gene/509.shtml
CleanEx	HS_ATP5C1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP5C1
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature02462	http://dx.doi.org/10.1038/nature02462
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AK292896	http://www.ebi.ac.uk/ena/data/view/AK292896
EMBL	AL158044	http://www.ebi.ac.uk/ena/data/view/AL158044
EMBL	AL158044	http://www.ebi.ac.uk/ena/data/view/AL158044
EMBL	AL158044	http://www.ebi.ac.uk/ena/data/view/AL158044
EMBL	AL158044	http://www.ebi.ac.uk/ena/data/view/AL158044
EMBL	AL353754	http://www.ebi.ac.uk/ena/data/view/AL353754
EMBL	AL353754	http://www.ebi.ac.uk/ena/data/view/AL353754
EMBL	AL353754	http://www.ebi.ac.uk/ena/data/view/AL353754
EMBL	AL353754	http://www.ebi.ac.uk/ena/data/view/AL353754
EMBL	BC000470	http://www.ebi.ac.uk/ena/data/view/BC000470
EMBL	BC000931	http://www.ebi.ac.uk/ena/data/view/BC000931
EMBL	BC013394	http://www.ebi.ac.uk/ena/data/view/BC013394
EMBL	BC016812	http://www.ebi.ac.uk/ena/data/view/BC016812
EMBL	BC020824	http://www.ebi.ac.uk/ena/data/view/BC020824
EMBL	CH471072	http://www.ebi.ac.uk/ena/data/view/CH471072
EMBL	CH471072	http://www.ebi.ac.uk/ena/data/view/CH471072
EMBL	CR457403	http://www.ebi.ac.uk/ena/data/view/CR457403
EMBL	D16561	http://www.ebi.ac.uk/ena/data/view/D16561
EMBL	D16561	http://www.ebi.ac.uk/ena/data/view/D16561
EMBL	D16562	http://www.ebi.ac.uk/ena/data/view/D16562
EMBL	D16563	http://www.ebi.ac.uk/ena/data/view/D16563
Ensembl	ENST00000335698	http://www.ensembl.org/id/ENST00000335698
Ensembl	ENST00000356708	http://www.ensembl.org/id/ENST00000356708
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000275	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000275
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005753	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005753
GO_component	GO:0005759	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005759
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0043209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043209
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GO_function	GO:0044822	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044822
GO_function	GO:0046933	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046933
GO_process	GO:0006119	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006119
GO_process	GO:0006754	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006754
GO_process	GO:0042776	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042776
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003723	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ATP5C1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP5C1
GeneID	509	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=509
GeneTree	ENSGT00390000006837	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000006837
HGNC	HGNC:833	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:833
HOGENOM	HOG000215911	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000215911&db=HOGENOM6
HOVERGEN	HBG000933	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000933&db=HOVERGEN
HPA	HPA060949	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA060949
InParanoid	P36542	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36542
IntAct	P36542	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36542*
InterPro	IPR000131	http://www.ebi.ac.uk/interpro/entry/IPR000131
InterPro	IPR023632	http://www.ebi.ac.uk/interpro/entry/IPR023632
Jabion	509	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=509
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:509	http://www.genome.jp/dbget-bin/www_bget?hsa:509
KEGG_Orthology	KO:K02136	http://www.genome.jp/dbget-bin/www_bget?KO:K02136
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	108729	http://www.ncbi.nlm.nih.gov/omim/108729
MINT	MINT-1378900	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1378900
OMA	YQEFALV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YQEFALV
OrthoDB	EOG091G0XX7	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0XX7
PANTHER	PTHR11693	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11693
PRINTS	PR00126	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00126
PROSITE	PS00153	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00153
PSORT	swissprot:ATPG_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ATPG_HUMAN
PSORT-B	swissprot:ATPG_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ATPG_HUMAN
PSORT2	swissprot:ATPG_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ATPG_HUMAN
Pfam	PF00231	http://pfam.xfam.org/family/PF00231
PharmGKB	PA25125	http://www.pharmgkb.org/do/serve?objId=PA25125&objCls=Gene
Phobius	swissprot:ATPG_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ATPG_HUMAN
PhylomeDB	P36542	http://phylomedb.org/?seqid=P36542
ProteinModelPortal	P36542	http://www.proteinmodelportal.org/query/uniprot/P36542
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15164054	http://www.ncbi.nlm.nih.gov/pubmed/15164054
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	8227057	http://www.ncbi.nlm.nih.gov/pubmed/8227057
Reactome	R-HSA-163210	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-163210
RefSeq	NP_001001973	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001001973
RefSeq	NP_005165	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005165
STRING	9606.ENSP00000349142	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000349142&targetmode=cogs
STRING	COG0224	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0224&targetmode=cogs
SUPFAM	SSF52943	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52943
TIGRFAMs	TIGR01146	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01146
UCSC	uc001iju	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001iju&org=rat
UniGene	Hs.271135	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.271135
UniProtKB	ATPG_HUMAN	http://www.uniprot.org/uniprot/ATPG_HUMAN
UniProtKB-AC	P36542	http://www.uniprot.org/uniprot/P36542
charge	swissprot:ATPG_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ATPG_HUMAN
eggNOG	COG0224	http://eggnogapi.embl.de/nog_data/html/tree/COG0224
eggNOG	KOG1531	http://eggnogapi.embl.de/nog_data/html/tree/KOG1531
epestfind	swissprot:ATPG_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ATPG_HUMAN
garnier	swissprot:ATPG_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ATPG_HUMAN
helixturnhelix	swissprot:ATPG_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATPG_HUMAN
hmoment	swissprot:ATPG_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ATPG_HUMAN
iep	swissprot:ATPG_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ATPG_HUMAN
inforesidue	swissprot:ATPG_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ATPG_HUMAN
neXtProt	NX_P36542	http://www.nextprot.org/db/entry/NX_P36542
octanol	swissprot:ATPG_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ATPG_HUMAN
pepcoil	swissprot:ATPG_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ATPG_HUMAN
pepdigest	swissprot:ATPG_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ATPG_HUMAN
pepinfo	swissprot:ATPG_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ATPG_HUMAN
pepnet	swissprot:ATPG_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ATPG_HUMAN
pepstats	swissprot:ATPG_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ATPG_HUMAN
pepwheel	swissprot:ATPG_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ATPG_HUMAN
pepwindow	swissprot:ATPG_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ATPG_HUMAN
sigcleave	swissprot:ATPG_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ATPG_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	107040	19
# CAUTION	It is uncertain whether Met-1 or Met-4 is the initiator. {ECO	0000305}. 
# ChiTaRS	AZGP1	human
# Ensembl	ENST00000292401	ENSP00000292401; ENSG00000160862
# ExpressionAtlas	P25311	baseline and differential
# FUNCTION	ZA2G_HUMAN	Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids. 
# GO_component	GO:0005576	extracellular region; NAS:UniProtKB.
# GO_component	GO:0005615	extracellular space; IDA:UniProtKB.
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0001948	glycoprotein binding; IPI:UniProtKB.
# GO_function	GO:0003823	antigen binding; IBA:GO_Central.
# GO_function	GO:0004540	ribonuclease activity; NAS:UniProtKB.
# GO_function	GO:0008320	protein transmembrane transporter activity; NAS:UniProtKB.
# GO_process	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste; IDA:UniProtKB.
# GO_process	GO:0001895	retina homeostasis; IEP:UniProtKB.
# GO_process	GO:0007155	cell adhesion; IDA:UniProtKB.
# GO_process	GO:0008285	negative regulation of cell proliferation; NAS:UniProtKB.
# GO_process	GO:0019882	antigen processing and presentation; IBA:GO_Central.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005576	extracellular region
# GOslim_component	GO:0005615	extracellular space
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004518	nuclease activity
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0007155	cell adhesion
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.40.10	-; 1.
# Gene3D	3.30.500.10	-; 1.
# Genevisible	P25311	HS
# HGNC	HGNC:910	AZGP1
# IntAct	P25311	14
# InterPro	IPR001039	MHC_I_a_a1/a2
# InterPro	IPR003006	Ig/MHC_CS
# InterPro	IPR003597	Ig_C1-set
# InterPro	IPR007110	Ig-like_dom
# InterPro	IPR011161	MHC_I-like_Ag-recog
# InterPro	IPR011162	MHC_I/II-like_Ag-recog
# InterPro	IPR013783	Ig-like_fold
# MIM	194460	gene
# Organism	ZA2G_HUMAN	Homo sapiens (Human)
# PDB	1T7V	X-ray; 1.95 A; A=21-298
# PDB	1T7W	X-ray; 2.70 A; A=21-298
# PDB	1T7X	X-ray; 3.10 A; A=21-298
# PDB	1T7Y	X-ray; 2.80 A; A=21-298
# PDB	1T7Z	X-ray; 3.00 A; A=21-298
# PDB	1T80	X-ray; 2.10 A; A=21-298
# PDB	1ZAG	X-ray; 2.80 A; A/B/C/D=25-298
# PDB	3ES6	X-ray; 3.23 A; A=21-298
# PIR	A54175	A54175
# PRINTS	PR01638	MHCCLASSI
# PROSITE	PS00290	IG_MHC
# PROSITE	PS50835	IG_LIKE
# PTM	ZA2G_HUMAN	N-glycosylated. N-glycan at Asn-128  Hex5HexNAc4. {ECO 0000269|PubMed 10206894, ECO 0000269|PubMed 14760718, ECO 0000269|PubMed 15084671, ECO 0000269|PubMed 15477100, ECO 0000269|PubMed 16335952, ECO 0000269|PubMed 16740002, ECO 0000269|PubMed 18780401, ECO 0000269|PubMed 18930737, ECO 0000269|PubMed 19139490, ECO 0000269|PubMed 19159218, ECO 0000269|PubMed 22171320}. 
# Pfam	PF00129	MHC_I
# Pfam	PF07654	C1-set
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-5223345	Miscellaneous transport and binding events
# RecName	ZA2G_HUMAN	Zinc-alpha-2-glycoprotein
# RefSeq	NP_001176	NM_001185.3
# SEQUENCE CAUTION	ZA2G_HUMAN	Sequence=AAA61311.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=BAA03123.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=BAA14417.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=CAA42438.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305};
# SIMILARITY	Belongs to the MHC class I family. {ECO	0000305}. 
# SIMILARITY	Contains 1 Ig-like C1-type (immunoglobulin-like) domain. {ECO	0000305}. 
# SMART	SM00407	IGc1
# SUBCELLULAR LOCATION	ZA2G_HUMAN	Secreted. 
# SUBUNIT	Interacts with PIP. {ECO:0000269|PubMed	18930737}. 
# SUPFAM	SSF48726	SSF48726
# SUPFAM	SSF54452	SSF54452
# TISSUE SPECIFICITY	ZA2G_HUMAN	Blood plasma, seminal plasma, urine, saliva, sweat, epithelial cells of various human glands, liver. 
# UCSC	uc003ush	human
# eggNOG	ENOG410J9FR	Eukaryota
# eggNOG	ENOG4111CJX	LUCA
BLAST	swissprot:ZA2G_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ZA2G_HUMAN
BioCyc	ZFISH:ENSG00000160862-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000160862-MONOMER
COXPRESdb	563	http://coxpresdb.jp/data/gene/563.shtml
CleanEx	HS_AZGP1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AZGP1
DOI	10.1002/pmic.200300556	http://dx.doi.org/10.1002/pmic.200300556
DOI	10.1002/pmic.200701057	http://dx.doi.org/10.1002/pmic.200701057
DOI	10.1016/0006-291X(91)91844-3	http://dx.doi.org/10.1016/0006-291X(91)91844-3
DOI	10.1016/0014-5793(91)81271-9	http://dx.doi.org/10.1016/0014-5793(91)81271-9
DOI	10.1016/S0888-7543(05)80359-3	http://dx.doi.org/10.1016/S0888-7543(05)80359-3
DOI	10.1016/j.jmb.2008.09.072	http://dx.doi.org/10.1016/j.jmb.2008.09.072
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.jsb.2004.04.009	http://dx.doi.org/10.1016/j.jsb.2004.04.009
DOI	10.1021/bi00211a004	http://dx.doi.org/10.1021/bi00211a004
DOI	10.1021/pr0502065	http://dx.doi.org/10.1021/pr0502065
DOI	10.1021/pr050492k	http://dx.doi.org/10.1021/pr050492k
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1073/pnas.85.3.679	http://dx.doi.org/10.1073/pnas.85.3.679
DOI	10.1073/pnas.94.9.4626	http://dx.doi.org/10.1073/pnas.94.9.4626
DOI	10.1074/jbc.C100301200	http://dx.doi.org/10.1074/jbc.C100301200
DOI	10.1074/mcp.M111.013649	http://dx.doi.org/10.1074/mcp.M111.013649
DOI	10.1074/mcp.M400015-MCP200	http://dx.doi.org/10.1074/mcp.M400015-MCP200
DOI	10.1074/mcp.M800504-MCP200	http://dx.doi.org/10.1074/mcp.M800504-MCP200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1110/ps.04682504	http://dx.doi.org/10.1110/ps.04682504
DOI	10.1126/science.1083423	http://dx.doi.org/10.1126/science.1083423
DOI	10.1126/science.283.5409.1914	http://dx.doi.org/10.1126/science.283.5409.1914
EMBL	AC004522	http://www.ebi.ac.uk/ena/data/view/AC004522
EMBL	BC005306	http://www.ebi.ac.uk/ena/data/view/BC005306
EMBL	BC033830	http://www.ebi.ac.uk/ena/data/view/BC033830
EMBL	CH236956	http://www.ebi.ac.uk/ena/data/view/CH236956
EMBL	CH471091	http://www.ebi.ac.uk/ena/data/view/CH471091
EMBL	CH471091	http://www.ebi.ac.uk/ena/data/view/CH471091
EMBL	D14034	http://www.ebi.ac.uk/ena/data/view/D14034
EMBL	D90427	http://www.ebi.ac.uk/ena/data/view/D90427
EMBL	M76707	http://www.ebi.ac.uk/ena/data/view/M76707
EMBL	X59766	http://www.ebi.ac.uk/ena/data/view/X59766
EMBL	X69953	http://www.ebi.ac.uk/ena/data/view/X69953
Ensembl	ENST00000292401	http://www.ensembl.org/id/ENST00000292401
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005576	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576
GO_component	GO:0005615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005615
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0001948	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001948
GO_function	GO:0003823	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003823
GO_function	GO:0004540	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004540
GO_function	GO:0008320	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008320
GO_process	GO:0001580	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001580
GO_process	GO:0001895	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001895
GO_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GO_process	GO:0008285	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008285
GO_process	GO:0019882	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019882
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005576	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576
GOslim_component	GO:0005615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005615
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004518	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.40.10	http://www.cathdb.info/version/latest/superfamily/2.60.40.10
Gene3D	3.30.500.10	http://www.cathdb.info/version/latest/superfamily/3.30.500.10
GeneCards	AZGP1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=AZGP1
GeneID	563	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=563
GeneTree	ENSGT00760000118960	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118960
HGNC	HGNC:910	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:910
HOGENOM	HOG000296917	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000296917&db=HOGENOM6
HOVERGEN	HBG016709	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG016709&db=HOVERGEN
HPA	CAB016087	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB016087
HPA	CAB032276	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB032276
HPA	HPA012582	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA012582
InParanoid	P25311	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25311
IntAct	P25311	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25311*
InterPro	IPR001039	http://www.ebi.ac.uk/interpro/entry/IPR001039
InterPro	IPR003006	http://www.ebi.ac.uk/interpro/entry/IPR003006
InterPro	IPR003597	http://www.ebi.ac.uk/interpro/entry/IPR003597
InterPro	IPR007110	http://www.ebi.ac.uk/interpro/entry/IPR007110
InterPro	IPR011161	http://www.ebi.ac.uk/interpro/entry/IPR011161
InterPro	IPR011162	http://www.ebi.ac.uk/interpro/entry/IPR011162
InterPro	IPR013783	http://www.ebi.ac.uk/interpro/entry/IPR013783
Jabion	563	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=563
KEGG_Gene	hsa:563	http://www.genome.jp/dbget-bin/www_bget?hsa:563
MIM	194460	http://www.ncbi.nlm.nih.gov/omim/194460
OMA	IFMVTLK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IFMVTLK
OrthoDB	EOG091G0K1X	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0K1X
PDB	1T7V	http://www.ebi.ac.uk/pdbe-srv/view/entry/1T7V
PDB	1T7W	http://www.ebi.ac.uk/pdbe-srv/view/entry/1T7W
PDB	1T7X	http://www.ebi.ac.uk/pdbe-srv/view/entry/1T7X
PDB	1T7Y	http://www.ebi.ac.uk/pdbe-srv/view/entry/1T7Y
PDB	1T7Z	http://www.ebi.ac.uk/pdbe-srv/view/entry/1T7Z
PDB	1T80	http://www.ebi.ac.uk/pdbe-srv/view/entry/1T80
PDB	1ZAG	http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZAG
PDB	3ES6	http://www.ebi.ac.uk/pdbe-srv/view/entry/3ES6
PDBsum	1T7V	http://www.ebi.ac.uk/pdbsum/1T7V
PDBsum	1T7W	http://www.ebi.ac.uk/pdbsum/1T7W
PDBsum	1T7X	http://www.ebi.ac.uk/pdbsum/1T7X
PDBsum	1T7Y	http://www.ebi.ac.uk/pdbsum/1T7Y
PDBsum	1T7Z	http://www.ebi.ac.uk/pdbsum/1T7Z
PDBsum	1T80	http://www.ebi.ac.uk/pdbsum/1T80
PDBsum	1ZAG	http://www.ebi.ac.uk/pdbsum/1ZAG
PDBsum	3ES6	http://www.ebi.ac.uk/pdbsum/3ES6
PRINTS	PR01638	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01638
PROSITE	PS00290	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00290
PROSITE	PS50835	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50835
PSORT	swissprot:ZA2G_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ZA2G_HUMAN
PSORT-B	swissprot:ZA2G_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ZA2G_HUMAN
PSORT2	swissprot:ZA2G_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ZA2G_HUMAN
Pfam	PF00129	http://pfam.xfam.org/family/PF00129
Pfam	PF07654	http://pfam.xfam.org/family/PF07654
PharmGKB	PA25203	http://www.pharmgkb.org/do/serve?objId=PA25203&objCls=Gene
Phobius	swissprot:ZA2G_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ZA2G_HUMAN
PhylomeDB	P25311	http://phylomedb.org/?seqid=P25311
ProteinModelPortal	P25311	http://www.proteinmodelportal.org/query/uniprot/P25311
PubMed	10206894	http://www.ncbi.nlm.nih.gov/pubmed/10206894
PubMed	11425849	http://www.ncbi.nlm.nih.gov/pubmed/11425849
PubMed	12690205	http://www.ncbi.nlm.nih.gov/pubmed/12690205
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	14760718	http://www.ncbi.nlm.nih.gov/pubmed/14760718
PubMed	15084671	http://www.ncbi.nlm.nih.gov/pubmed/15084671
PubMed	15340161	http://www.ncbi.nlm.nih.gov/pubmed/15340161
PubMed	15477100	http://www.ncbi.nlm.nih.gov/pubmed/15477100
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16335952	http://www.ncbi.nlm.nih.gov/pubmed/16335952
PubMed	16740002	http://www.ncbi.nlm.nih.gov/pubmed/16740002
PubMed	18780401	http://www.ncbi.nlm.nih.gov/pubmed/18780401
PubMed	18930737	http://www.ncbi.nlm.nih.gov/pubmed/18930737
PubMed	19139490	http://www.ncbi.nlm.nih.gov/pubmed/19139490
PubMed	1915885	http://www.ncbi.nlm.nih.gov/pubmed/1915885
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	2049092	http://www.ncbi.nlm.nih.gov/pubmed/2049092
PubMed	22171320	http://www.ncbi.nlm.nih.gov/pubmed/22171320
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	3422450	http://www.ncbi.nlm.nih.gov/pubmed/3422450
PubMed	8241150	http://www.ncbi.nlm.nih.gov/pubmed/8241150
PubMed	8307568	http://www.ncbi.nlm.nih.gov/pubmed/8307568
PubMed	9114041	http://www.ncbi.nlm.nih.gov/pubmed/9114041
Reactome	R-HSA-5223345	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5223345
RefSeq	NP_001176	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001176
SMART	SM00407	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00407
SMR	P25311	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P25311
STRING	9606.ENSP00000292401	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000292401&targetmode=cogs
SUPFAM	SSF48726	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48726
SUPFAM	SSF54452	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54452
SWISS-2DPAGE	P25311	http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P25311
UCSC	uc003ush	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ush&org=rat
UniGene	Hs.546239	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.546239
UniProtKB	ZA2G_HUMAN	http://www.uniprot.org/uniprot/ZA2G_HUMAN
UniProtKB-AC	P25311	http://www.uniprot.org/uniprot/P25311
charge	swissprot:ZA2G_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ZA2G_HUMAN
eggNOG	ENOG410J9FR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410J9FR
eggNOG	ENOG4111CJX	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111CJX
epestfind	swissprot:ZA2G_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ZA2G_HUMAN
garnier	swissprot:ZA2G_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ZA2G_HUMAN
helixturnhelix	swissprot:ZA2G_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZA2G_HUMAN
hmoment	swissprot:ZA2G_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ZA2G_HUMAN
iep	swissprot:ZA2G_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ZA2G_HUMAN
inforesidue	swissprot:ZA2G_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ZA2G_HUMAN
neXtProt	NX_P25311	http://www.nextprot.org/db/entry/NX_P25311
octanol	swissprot:ZA2G_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ZA2G_HUMAN
pepcoil	swissprot:ZA2G_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ZA2G_HUMAN
pepdigest	swissprot:ZA2G_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ZA2G_HUMAN
pepinfo	swissprot:ZA2G_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ZA2G_HUMAN
pepnet	swissprot:ZA2G_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ZA2G_HUMAN
pepstats	swissprot:ZA2G_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ZA2G_HUMAN
pepwheel	swissprot:ZA2G_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ZA2G_HUMAN
pepwindow	swissprot:ZA2G_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ZA2G_HUMAN
sigcleave	swissprot:ZA2G_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ZA2G_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CXD3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N144-1; Sequence=Displayed; Name=2; IsoId=Q8N144-2; Sequence=VSP_029984; Note=No experimental confirmation available.; 
# AltName	CXD3_HUMAN	Connexin-31.9
# AltName	CXD3_HUMAN	Gap junction alpha-11 protein
# AltName	CXD3_HUMAN	Gap junction chi-1 protein
# CCDS	CCDS58547	-. [Q8N144-1]
# Ensembl	ENST00000578689	ENSP00000463752; ENSG00000183153. [Q8N144-1]
# FUNCTION	CXD3_HUMAN	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. {ECO 0000250}. 
# GO_component	GO:0005887	integral component of plasma membrane; TAS:UniProtKB.
# GO_component	GO:0005922	connexin complex; IDA:UniProtKB.
# GO_component	GO:0009986	cell surface; IDA:UniProtKB.
# GO_function	GO:0005216	ion channel activity; IEA:Ensembl.
# GO_function	GO:0005243	gap junction channel activity; IEA:Ensembl.
# GO_process	GO:0007154	cell communication; TAS:UniProtKB.
# GO_process	GO:0009749	response to glucose; IEA:Ensembl.
# GO_process	GO:0016264	gap junction assembly; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0022607	cellular component assembly
# GOslim_process	GO:0034330	cell junction organization
# Genevisible	Q8N144	HS
# HGNC	HGNC:19147	GJD3
# INTERACTION	CXD3_HUMAN	Q07157 TJP1; NbExp=2; IntAct=EBI-2629520, EBI-79553; 
# InterPro	IPR000500	Connexin
# InterPro	IPR013092	Connexin_N
# InterPro	IPR017990	Connexin_CS
# InterPro	IPR019570	Connexin_CCC
# MIM	607425	gene
# Organism	CXD3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11984	PTHR11984
# PRINTS	PR00206	CONNEXIN
# PROSITE	PS00408	CONNEXINS_2
# Pfam	PF00029	Connexin
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-190861	Gap junction assembly
# RecName	CXD3_HUMAN	Gap junction delta-3 protein
# RefSeq	NP_689343	NM_152219.3. [Q8N144-1]
# SIMILARITY	Belongs to the connexin family. Delta-type subfamily. {ECO	0000305}.
# SMART	SM00037	CNX
# SMART	SM01089	Connexin_CCC
# SUBCELLULAR LOCATION	CXD3_HUMAN	Cell membrane {ECO 0000269|PubMed 12154091}; Multi-pass membrane protein {ECO 0000269|PubMed 12154091}. Cell junction, gap junction {ECO 0000269|PubMed 12154091}. 
# SUBUNIT	A connexon is composed of a hexamer of connexins (By similarity). Interacts with TJP1. {ECO:0000250, ECO	0000269|PubMed:12154091}. 
# TISSUE SPECIFICITY	CXD3_HUMAN	Expressed in vascular smooth muscle cells. Found in heart, colon, and artery (at protein level). Found in cerebral cortex, heart, liver, lung, kidney, spleen and testis. {ECO 0000269|PubMed 12154091, ECO 0000269|PubMed 12176752}. 
# UCSC	uc010cwz	human. [Q8N144-1]
# eggNOG	ENOG410IEGI	Eukaryota
# eggNOG	ENOG4111HI4	LUCA
BLAST	swissprot:CXD3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CXD3_HUMAN
BioCyc	ZFISH:G66-32416-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32416-MONOMER
COXPRESdb	125111	http://coxpresdb.jp/data/gene/125111.shtml
CleanEx	HS_GJC1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GJC1
CleanEx	HS_GJD3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GJD3
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M205348200	http://dx.doi.org/10.1074/jbc.M205348200
DOI	10.1152/ajpcell.00163.2002	http://dx.doi.org/10.1152/ajpcell.00163.2002
EMBL	AF514298	http://www.ebi.ac.uk/ena/data/view/AF514298
EMBL	AK125254	http://www.ebi.ac.uk/ena/data/view/AK125254
EMBL	AY093445	http://www.ebi.ac.uk/ena/data/view/AY093445
EMBL	CH471152	http://www.ebi.ac.uk/ena/data/view/CH471152
Ensembl	ENST00000578689	http://www.ensembl.org/id/ENST00000578689
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005922	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005922
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_function	GO:0005216	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005216
GO_function	GO:0005243	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005243
GO_process	GO:0007154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007154
GO_process	GO:0009749	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009749
GO_process	GO:0016264	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016264
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0022607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607
GOslim_process	GO:0034330	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034330
GeneCards	GJD3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GJD3
GeneID	125111	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=125111
GeneTree	ENSGT00840000129674	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00840000129674
H-InvDB	HIX0079908	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0079908
HGNC	HGNC:19147	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:19147
HOGENOM	HOG000231127	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231127&db=HOGENOM6
HOVERGEN	HBG009576	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG009576&db=HOVERGEN
InParanoid	Q8N144	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8N144
IntAct	Q8N144	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8N144*
InterPro	IPR000500	http://www.ebi.ac.uk/interpro/entry/IPR000500
InterPro	IPR013092	http://www.ebi.ac.uk/interpro/entry/IPR013092
InterPro	IPR017990	http://www.ebi.ac.uk/interpro/entry/IPR017990
InterPro	IPR019570	http://www.ebi.ac.uk/interpro/entry/IPR019570
Jabion	125111	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=125111
KEGG_Gene	hsa:125111	http://www.genome.jp/dbget-bin/www_bget?hsa:125111
KEGG_Orthology	KO:K07627	http://www.genome.jp/dbget-bin/www_bget?KO:K07627
MIM	607425	http://www.ncbi.nlm.nih.gov/omim/607425
OMA	ACAGPPC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ACAGPPC
OrthoDB	EOG091G0KR7	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0KR7
PANTHER	PTHR11984	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11984
PRINTS	PR00206	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00206
PROSITE	PS00408	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00408
PSORT	swissprot:CXD3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CXD3_HUMAN
PSORT-B	swissprot:CXD3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CXD3_HUMAN
PSORT2	swissprot:CXD3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CXD3_HUMAN
Pfam	PF00029	http://pfam.xfam.org/family/PF00029
PharmGKB	PA162389707	http://www.pharmgkb.org/do/serve?objId=PA162389707&objCls=Gene
Phobius	swissprot:CXD3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CXD3_HUMAN
PhylomeDB	Q8N144	http://phylomedb.org/?seqid=Q8N144
ProteinModelPortal	Q8N144	http://www.proteinmodelportal.org/query/uniprot/Q8N144
PubMed	12154091	http://www.ncbi.nlm.nih.gov/pubmed/12154091
PubMed	12176752	http://www.ncbi.nlm.nih.gov/pubmed/12176752
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
Reactome	R-HSA-190861	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-190861
RefSeq	NP_689343	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_689343
SMART	SM00037	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00037
SMART	SM01089	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01089
STRING	9606.ENSP00000336832	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000336832&targetmode=cogs
UCSC	uc010cwz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010cwz&org=rat
UniGene	Hs.444663	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.444663
UniProtKB	CXD3_HUMAN	http://www.uniprot.org/uniprot/CXD3_HUMAN
UniProtKB-AC	Q8N144	http://www.uniprot.org/uniprot/Q8N144
charge	swissprot:CXD3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CXD3_HUMAN
eggNOG	ENOG410IEGI	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IEGI
eggNOG	ENOG4111HI4	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111HI4
epestfind	swissprot:CXD3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CXD3_HUMAN
garnier	swissprot:CXD3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CXD3_HUMAN
helixturnhelix	swissprot:CXD3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CXD3_HUMAN
hmoment	swissprot:CXD3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CXD3_HUMAN
iep	swissprot:CXD3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CXD3_HUMAN
inforesidue	swissprot:CXD3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CXD3_HUMAN
neXtProt	NX_Q8N144	http://www.nextprot.org/db/entry/NX_Q8N144
octanol	swissprot:CXD3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CXD3_HUMAN
pepcoil	swissprot:CXD3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CXD3_HUMAN
pepdigest	swissprot:CXD3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CXD3_HUMAN
pepinfo	swissprot:CXD3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CXD3_HUMAN
pepnet	swissprot:CXD3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CXD3_HUMAN
pepstats	swissprot:CXD3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CXD3_HUMAN
pepwheel	swissprot:CXD3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CXD3_HUMAN
pepwindow	swissprot:CXD3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CXD3_HUMAN
sigcleave	swissprot:CXD3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CXD3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=A1H-a; IsoId=O95180-1; Sequence=Displayed; Name=2; Synonyms=A1H-b; IsoId=O95180-2; Sequence=VSP_000949; Note=Ref.4 (CAD12646) sequence is in conflict in position: 1587	K->E. {ECO:0000305}; 
# AltName	CAC1H_HUMAN	Low-voltage-activated calcium channel alpha1 3.2 subunit
# AltName	CAC1H_HUMAN	Voltage-gated calcium channel subunit alpha Cav3.2
# BioGrid	114426	5
# CCDS	CCDS45375	-. [O95180-1]
# CCDS	CCDS45376	-. [O95180-2]
# ChiTaRS	CACNA1H	human
# DISEASE	CAC1H_HUMAN	Epilepsy, childhood absence 6 (ECA6) [MIM 611942]  A subtype of idiopathic generalized epilepsy characterized by an onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. Tonic-clonic seizures often develop in adolescence. Absence seizures may either remit or persist into adulthood. {ECO 0000269|PubMed 12891677}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# DISEASE	CAC1H_HUMAN	Epilepsy, idiopathic generalized 6 (EIG6) [MIM 611942]  A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. {ECO 0000269|PubMed 15048902}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# DOMAIN	CAC1H_HUMAN	Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position. 
# DrugBank	DB00270	Isradipine
# DrugBank	DB00421	Spironolactone
# DrugBank	DB00568	Cinnarizine
# DrugBank	DB00909	Zonisamide
# DrugBank	DB01023	Felodipine
# DrugBank	DB01054	Nitrendipine
# DrugBank	DB01115	Nifedipine
# DrugBank	DB01118	Amiodarone
# DrugBank	DB01244	Bepridil
# DrugBank	DB04841	Flunarizine
# Ensembl	ENST00000348261	ENSP00000334198; ENSG00000196557. [O95180-1]
# Ensembl	ENST00000358590	ENSP00000351401; ENSG00000196557. [O95180-2]
# Ensembl	ENST00000565831	ENSP00000455840; ENSG00000196557. [O95180-2]
# ExpressionAtlas	O95180	baseline and differential
# FUNCTION	CAC1H_HUMAN	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1H gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. 
# GO_component	GO:0005891	voltage-gated calcium channel complex; TAS:ProtInc.
# GO_component	GO:0016021	integral component of membrane; IDA:BHF-UCL.
# GO_function	GO:0008332	low voltage-gated calcium channel activity; IDA:BHF-UCL.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_function	GO:0097110	scaffold protein binding; IPI:BHF-UCL.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006936	muscle contraction; TAS:ProtInc.
# GO_process	GO:0007517	muscle organ development; NAS:ProtInc.
# GO_process	GO:0007520	myoblast fusion; TAS:ProtInc.
# GO_process	GO:0008016	regulation of heart contraction; TAS:ProtInc.
# GO_process	GO:0032342	aldosterone biosynthetic process; IMP:UniProtKB.
# GO_process	GO:0032870	cellular response to hormone stimulus; IEP:UniProtKB.
# GO_process	GO:0034651	cortisol biosynthetic process; IMP:UniProtKB.
# GO_process	GO:0035865	cellular response to potassium ion; IEP:UniProtKB.
# GO_process	GO:0042391	regulation of membrane potential; IDA:BHF-UCL.
# GO_process	GO:0070509	calcium ion import; IDA:BHF-UCL.
# GO_process	GO:0086010	membrane depolarization during action potential; IBA:GO_Central.
# GO_process	GO:2000344	positive regulation of acrosome reaction; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0048646	anatomical structure formation involved in morphogenesis
# GOslim_process	GO:0048856	anatomical structure development
# Gene3D	1.20.120.350	-; 4.
# Genevisible	O95180	HS
# HGNC	HGNC:1395	CACNA1H
# IntAct	O95180	2
# InterPro	IPR005445	VDCC_T_a1
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR030160	VDCC_T_a1H
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04010	MAPK signaling pathway
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04713	Circadian entrainment
# MIM	607904	gene
# MIM	611942	phenotype
# Organism	CAC1H_HUMAN	Homo sapiens (Human)
# Orphanet	64280	Childhood absence epilepsy
# PANTHER	PTHR10037:SF192	PTHR10037:SF192; 4
# PRINTS	PR01629	TVDCCALPHA1
# PTM	CAC1H_HUMAN	In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II. 
# Pfam	PF00520	Ion_trans; 4
# Proteomes	UP000005640	Chromosome 16
# Reactome	R-HSA-419037	NCAM1 interactions
# RecName	CAC1H_HUMAN	Voltage-dependent T-type calcium channel subunit alpha-1H
# RefSeq	NP_001005407	NM_001005407.1. [O95180-2]
# RefSeq	NP_066921	NM_021098.2. [O95180-1]
# SEQUENCE CAUTION	Sequence=AAK61268.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAC42094.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1H subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	CAC1H_HUMAN	Membrane; Multi-pass membrane protein. 
# TCDB	1.A.1.11	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	CAC1H_HUMAN	Expressed in kidney, liver, heart, brain. Isoform 2 seems to be testis-specific. 
# UCSC	uc002cks	human. [O95180-1]
# eggNOG	COG1226	LUCA
# eggNOG	ENOG410IP4J	Eukaryota
BLAST	swissprot:CAC1H_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CAC1H_HUMAN
BioCyc	ZFISH:G66-33641-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33641-MONOMER
COXPRESdb	8912	http://coxpresdb.jp/data/gene/8912.shtml
CleanEx	HS_CACNA1H	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CACNA1H
DOI	10.1002/ana.10607	http://dx.doi.org/10.1002/ana.10607
DOI	10.1002/ana.20028	http://dx.doi.org/10.1002/ana.20028
DOI	10.1038/nature03187	http://dx.doi.org/10.1038/nature03187
DOI	10.1046/j.1471-4159.1999.0720791.x	http://dx.doi.org/10.1046/j.1471-4159.1999.0720791.x
DOI	10.1074/jbc.M105345200	http://dx.doi.org/10.1074/jbc.M105345200
DOI	10.1074/jbc.M109.067660	http://dx.doi.org/10.1074/jbc.M109.067660
DOI	10.1093/hmg/10.4.339	http://dx.doi.org/10.1093/hmg/10.4.339
DOI	10.1161/01.RES.83.1.103	http://dx.doi.org/10.1161/01.RES.83.1.103
DrugBank	DB00270	http://www.drugbank.ca/drugs/DB00270
DrugBank	DB00421	http://www.drugbank.ca/drugs/DB00421
DrugBank	DB00568	http://www.drugbank.ca/drugs/DB00568
DrugBank	DB00909	http://www.drugbank.ca/drugs/DB00909
DrugBank	DB01023	http://www.drugbank.ca/drugs/DB01023
DrugBank	DB01054	http://www.drugbank.ca/drugs/DB01054
DrugBank	DB01115	http://www.drugbank.ca/drugs/DB01115
DrugBank	DB01118	http://www.drugbank.ca/drugs/DB01118
DrugBank	DB01244	http://www.drugbank.ca/drugs/DB01244
DrugBank	DB04841	http://www.drugbank.ca/drugs/DB04841
EMBL	AC120498	http://www.ebi.ac.uk/ena/data/view/AC120498
EMBL	AE006466	http://www.ebi.ac.uk/ena/data/view/AE006466
EMBL	AF051946	http://www.ebi.ac.uk/ena/data/view/AF051946
EMBL	AF073931	http://www.ebi.ac.uk/ena/data/view/AF073931
EMBL	AF223562	http://www.ebi.ac.uk/ena/data/view/AF223562
EMBL	AF223563	http://www.ebi.ac.uk/ena/data/view/AF223563
EMBL	AJ420779	http://www.ebi.ac.uk/ena/data/view/AJ420779
EMBL	AL031703	http://www.ebi.ac.uk/ena/data/view/AL031703
Ensembl	ENST00000348261	http://www.ensembl.org/id/ENST00000348261
Ensembl	ENST00000358590	http://www.ensembl.org/id/ENST00000358590
Ensembl	ENST00000565831	http://www.ensembl.org/id/ENST00000565831
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005891
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0008332	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008332
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_function	GO:0097110	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097110
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006936	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006936
GO_process	GO:0007517	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007517
GO_process	GO:0007520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007520
GO_process	GO:0008016	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008016
GO_process	GO:0032342	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032342
GO_process	GO:0032870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032870
GO_process	GO:0034651	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034651
GO_process	GO:0035865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035865
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0070509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070509
GO_process	GO:0086010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086010
GO_process	GO:2000344	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000344
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0048646	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048646
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	CACNA1H	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CACNA1H
GeneID	8912	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8912
GeneTree	ENSGT00830000128242	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00830000128242
H-InvDB	HIX0038538	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0038538
HGNC	HGNC:1395	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1395
HOVERGEN	HBG050764	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050764&db=HOVERGEN
HPA	HPA039125	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA039125
InParanoid	O95180	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O95180
IntAct	O95180	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O95180*
InterPro	IPR005445	http://www.ebi.ac.uk/interpro/entry/IPR005445
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR030160	http://www.ebi.ac.uk/interpro/entry/IPR030160
Jabion	8912	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=8912
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:8912	http://www.genome.jp/dbget-bin/www_bget?hsa:8912
KEGG_Orthology	KO:K04855	http://www.genome.jp/dbget-bin/www_bget?KO:K04855
KEGG_Pathway	ko04010	http://www.genome.jp/kegg-bin/show_pathway?ko04010
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04713	http://www.genome.jp/kegg-bin/show_pathway?ko04713
MIM	607904	http://www.ncbi.nlm.nih.gov/omim/607904
MIM	611942	http://www.ncbi.nlm.nih.gov/omim/611942
OMA	KMYSLAV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KMYSLAV
Orphanet	64280	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=64280
OrthoDB	EOG091G02L1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02L1
PANTHER	PTHR10037:SF192	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10037:SF192
PRINTS	PR01629	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01629
PSORT	swissprot:CAC1H_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CAC1H_HUMAN
PSORT-B	swissprot:CAC1H_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CAC1H_HUMAN
PSORT2	swissprot:CAC1H_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CAC1H_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
PharmGKB	PA380	http://www.pharmgkb.org/do/serve?objId=PA380&objCls=Gene
Phobius	swissprot:CAC1H_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CAC1H_HUMAN
PhylomeDB	O95180	http://phylomedb.org/?seqid=O95180
ProteinModelPortal	O95180	http://www.proteinmodelportal.org/query/uniprot/O95180
PubMed	11157797	http://www.ncbi.nlm.nih.gov/pubmed/11157797
PubMed	11751928	http://www.ncbi.nlm.nih.gov/pubmed/11751928
PubMed	12891677	http://www.ncbi.nlm.nih.gov/pubmed/12891677
PubMed	15048902	http://www.ncbi.nlm.nih.gov/pubmed/15048902
PubMed	15616553	http://www.ncbi.nlm.nih.gov/pubmed/15616553
PubMed	19940152	http://www.ncbi.nlm.nih.gov/pubmed/19940152
PubMed	9670923	http://www.ncbi.nlm.nih.gov/pubmed/9670923
PubMed	9930755	http://www.ncbi.nlm.nih.gov/pubmed/9930755
Reactome	R-HSA-419037	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-419037
RefSeq	NP_001005407	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001005407
RefSeq	NP_066921	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_066921
STRING	9606.ENSP00000334198	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000334198&targetmode=cogs
TCDB	1.A.1.11	http://www.tcdb.org/search/result.php?tc=1.A.1.11
UCSC	uc002cks	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002cks&org=rat
UniGene	Hs.459642	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.459642
UniProtKB	CAC1H_HUMAN	http://www.uniprot.org/uniprot/CAC1H_HUMAN
UniProtKB-AC	O95180	http://www.uniprot.org/uniprot/O95180
charge	swissprot:CAC1H_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CAC1H_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	ENOG410IP4J	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IP4J
epestfind	swissprot:CAC1H_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CAC1H_HUMAN
garnier	swissprot:CAC1H_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CAC1H_HUMAN
helixturnhelix	swissprot:CAC1H_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CAC1H_HUMAN
hmoment	swissprot:CAC1H_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CAC1H_HUMAN
iep	swissprot:CAC1H_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CAC1H_HUMAN
inforesidue	swissprot:CAC1H_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CAC1H_HUMAN
neXtProt	NX_O95180	http://www.nextprot.org/db/entry/NX_O95180
octanol	swissprot:CAC1H_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CAC1H_HUMAN
pepcoil	swissprot:CAC1H_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CAC1H_HUMAN
pepdigest	swissprot:CAC1H_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CAC1H_HUMAN
pepinfo	swissprot:CAC1H_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CAC1H_HUMAN
pepnet	swissprot:CAC1H_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CAC1H_HUMAN
pepstats	swissprot:CAC1H_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CAC1H_HUMAN
pepwheel	swissprot:CAC1H_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CAC1H_HUMAN
pepwindow	swissprot:CAC1H_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CAC1H_HUMAN
sigcleave	swissprot:CAC1H_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CAC1H_HUMAN
## Database	ID	URL or Descriptions
# AltName	NCKX3_HUMAN	Na(+)/K(+)/Ca(2+)-exchange protein 3
# AltName	NCKX3_HUMAN	Solute carrier family 24 member 3
# ChiTaRS	SLC24A3	human
# Ensembl	ENST00000328041	ENSP00000333519; ENSG00000185052
# Ensembl	ENST00000613834	ENSP00000482967; ENSG00000185052
# FUNCTION	NCKX3_HUMAN	Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0005262	calcium channel activity; IBA:GO_Central.
# GO_function	GO:0005509	calcium ion binding; IBA:GO_Central.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_function	GO:0030955	potassium ion binding; IBA:GO_Central.
# GO_function	GO:0031402	sodium ion binding; IBA:GO_Central.
# GO_function	NCKX3_HUMAN	GO 0008273 calcium, potassium sodium antiporter activity; IBA GO_Central.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006874	cellular calcium ion homeostasis; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0042592	homeostatic process
# Genevisible	Q9HC58	HS
# HGNC	HGNC:10977	SLC24A3
# InterPro	IPR004481	K/Na/Ca-exchanger
# InterPro	IPR004837	NaCa_Exmemb
# InterPro	IPR030248	SLC24A3
# KEGG_Brite	ko02001	Solute carrier family
# MIM	609839	gene
# Organism	NCKX3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10846	PTHR10846
# PANTHER	PTHR10846:SF22	PTHR10846:SF22
# Pfam	PF01699	Na_Ca_ex; 2
# Proteomes	UP000005640	Chromosome 20
# Reactome	R-HSA-425561	Sodium/Calcium exchangers
# RecName	NCKX3_HUMAN	Sodium/potassium/calcium exchanger 3
# RefSeq	NP_065740	NM_020689.3
# SIMILARITY	Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	NCKX3_HUMAN	Membrane; Multi-pass membrane protein. 
# TCDB	2.A.19.4.10:the ca(2+)	cation antiporter (caca) family
# TIGRFAMs	TIGR00367	TIGR00367
# TISSUE SPECIFICITY	NCKX3_HUMAN	Abundant in the brain. Expressed at low levels in the aorta, uterus and intestine. 
# UCSC	uc002wrl	human
# eggNOG	ENOG410Y9YY	LUCA
# eggNOG	KOG1307	Eukaryota
BLAST	swissprot:NCKX3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NCKX3_HUMAN
BioCyc	ZFISH:G66-30813-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-30813-MONOMER
COXPRESdb	57419	http://coxpresdb.jp/data/gene/57419.shtml
CleanEx	HS_SLC24A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC24A3
DOI	10.1038/414865a	http://dx.doi.org/10.1038/414865a
DOI	10.1074/jbc.M102314200	http://dx.doi.org/10.1074/jbc.M102314200
EMBL	AF169257	http://www.ebi.ac.uk/ena/data/view/AF169257
EMBL	AF288087	http://www.ebi.ac.uk/ena/data/view/AF288087
EMBL	AL034425	http://www.ebi.ac.uk/ena/data/view/AL034425
EMBL	AL034425	http://www.ebi.ac.uk/ena/data/view/AL034425
EMBL	AL034425	http://www.ebi.ac.uk/ena/data/view/AL034425
EMBL	AL034425	http://www.ebi.ac.uk/ena/data/view/AL034425
EMBL	AL034425	http://www.ebi.ac.uk/ena/data/view/AL034425
EMBL	AL034425	http://www.ebi.ac.uk/ena/data/view/AL034425
EMBL	AL049647	http://www.ebi.ac.uk/ena/data/view/AL049647
EMBL	AL049647	http://www.ebi.ac.uk/ena/data/view/AL049647
EMBL	AL049647	http://www.ebi.ac.uk/ena/data/view/AL049647
EMBL	AL049647	http://www.ebi.ac.uk/ena/data/view/AL049647
EMBL	AL049647	http://www.ebi.ac.uk/ena/data/view/AL049647
EMBL	AL049647	http://www.ebi.ac.uk/ena/data/view/AL049647
EMBL	AL121761	http://www.ebi.ac.uk/ena/data/view/AL121761
EMBL	AL121761	http://www.ebi.ac.uk/ena/data/view/AL121761
EMBL	AL121761	http://www.ebi.ac.uk/ena/data/view/AL121761
EMBL	AL121761	http://www.ebi.ac.uk/ena/data/view/AL121761
EMBL	AL121761	http://www.ebi.ac.uk/ena/data/view/AL121761
EMBL	AL121761	http://www.ebi.ac.uk/ena/data/view/AL121761
EMBL	AL121830	http://www.ebi.ac.uk/ena/data/view/AL121830
EMBL	AL121830	http://www.ebi.ac.uk/ena/data/view/AL121830
EMBL	AL121830	http://www.ebi.ac.uk/ena/data/view/AL121830
EMBL	AL121830	http://www.ebi.ac.uk/ena/data/view/AL121830
EMBL	AL121830	http://www.ebi.ac.uk/ena/data/view/AL121830
EMBL	AL121830	http://www.ebi.ac.uk/ena/data/view/AL121830
EMBL	AL136090	http://www.ebi.ac.uk/ena/data/view/AL136090
EMBL	AL136090	http://www.ebi.ac.uk/ena/data/view/AL136090
EMBL	AL136090	http://www.ebi.ac.uk/ena/data/view/AL136090
EMBL	AL136090	http://www.ebi.ac.uk/ena/data/view/AL136090
EMBL	AL136090	http://www.ebi.ac.uk/ena/data/view/AL136090
EMBL	AL136090	http://www.ebi.ac.uk/ena/data/view/AL136090
EMBL	AL139429	http://www.ebi.ac.uk/ena/data/view/AL139429
EMBL	AL139429	http://www.ebi.ac.uk/ena/data/view/AL139429
EMBL	AL139429	http://www.ebi.ac.uk/ena/data/view/AL139429
EMBL	AL139429	http://www.ebi.ac.uk/ena/data/view/AL139429
EMBL	AL139429	http://www.ebi.ac.uk/ena/data/view/AL139429
EMBL	AL139429	http://www.ebi.ac.uk/ena/data/view/AL139429
Ensembl	ENST00000328041	http://www.ensembl.org/id/ENST00000328041
Ensembl	ENST00000613834	http://www.ensembl.org/id/ENST00000613834
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0008273	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008273
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_function	GO:0030955	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030955
GO_function	GO:0031402	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031402
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GeneCards	SLC24A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC24A3
GeneID	57419	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57419
GeneTree	ENSGT00760000119209	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119209
H-InvDB	HIX0040511	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0040511
HGNC	HGNC:10977	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10977
HOGENOM	HOG000231933	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231933&db=HOGENOM6
HOVERGEN	HBG054881	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054881&db=HOVERGEN
HPA	HPA043400	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA043400
HPA	HPA045497	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA045497
InParanoid	Q9HC58	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9HC58
InterPro	IPR004481	http://www.ebi.ac.uk/interpro/entry/IPR004481
InterPro	IPR004837	http://www.ebi.ac.uk/interpro/entry/IPR004837
InterPro	IPR030248	http://www.ebi.ac.uk/interpro/entry/IPR030248
Jabion	57419	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=57419
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:57419	http://www.genome.jp/dbget-bin/www_bget?hsa:57419
KEGG_Orthology	KO:K13751	http://www.genome.jp/dbget-bin/www_bget?KO:K13751
MIM	609839	http://www.ncbi.nlm.nih.gov/omim/609839
OMA	LGCGCLF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LGCGCLF
OrthoDB	EOG091G0M5C	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0M5C
PANTHER	PTHR10846	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10846
PANTHER	PTHR10846:SF22	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10846:SF22
PSORT	swissprot:NCKX3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NCKX3_HUMAN
PSORT-B	swissprot:NCKX3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NCKX3_HUMAN
PSORT2	swissprot:NCKX3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NCKX3_HUMAN
Pfam	PF01699	http://pfam.xfam.org/family/PF01699
PharmGKB	PA35853	http://www.pharmgkb.org/do/serve?objId=PA35853&objCls=Gene
Phobius	swissprot:NCKX3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NCKX3_HUMAN
PhylomeDB	Q9HC58	http://phylomedb.org/?seqid=Q9HC58
ProteinModelPortal	Q9HC58	http://www.proteinmodelportal.org/query/uniprot/Q9HC58
PubMed	11294880	http://www.ncbi.nlm.nih.gov/pubmed/11294880
PubMed	11780052	http://www.ncbi.nlm.nih.gov/pubmed/11780052
Reactome	R-HSA-425561	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425561
RefSeq	NP_065740	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_065740
STRING	9606.ENSP00000333519	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000333519&targetmode=cogs
TCDB	2.A.19.4.10	http://www.tcdb.org/search/result.php?tc=2.A.19.4.10
TIGRFAMs	TIGR00367	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00367
UCSC	uc002wrl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002wrl&org=rat
UniGene	Hs.654790	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.654790
UniProtKB	NCKX3_HUMAN	http://www.uniprot.org/uniprot/NCKX3_HUMAN
UniProtKB-AC	Q9HC58	http://www.uniprot.org/uniprot/Q9HC58
charge	swissprot:NCKX3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NCKX3_HUMAN
eggNOG	ENOG410Y9YY	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y9YY
eggNOG	KOG1307	http://eggnogapi.embl.de/nog_data/html/tree/KOG1307
epestfind	swissprot:NCKX3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NCKX3_HUMAN
garnier	swissprot:NCKX3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NCKX3_HUMAN
helixturnhelix	swissprot:NCKX3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NCKX3_HUMAN
hmoment	swissprot:NCKX3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NCKX3_HUMAN
iep	swissprot:NCKX3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NCKX3_HUMAN
inforesidue	swissprot:NCKX3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NCKX3_HUMAN
neXtProt	NX_Q9HC58	http://www.nextprot.org/db/entry/NX_Q9HC58
octanol	swissprot:NCKX3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NCKX3_HUMAN
pepcoil	swissprot:NCKX3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NCKX3_HUMAN
pepdigest	swissprot:NCKX3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NCKX3_HUMAN
pepinfo	swissprot:NCKX3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NCKX3_HUMAN
pepnet	swissprot:NCKX3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NCKX3_HUMAN
pepstats	swissprot:NCKX3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NCKX3_HUMAN
pepwheel	swissprot:NCKX3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NCKX3_HUMAN
pepwindow	swissprot:NCKX3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NCKX3_HUMAN
sigcleave	swissprot:NCKX3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NCKX3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	PSN1_HUMAN	Event=Alternative splicing; Named isoforms=7; Name=1; Synonyms=I-467; IsoId=P49768-1; Sequence=Displayed; Name=2; Synonyms=I-463; IsoId=P49768-2; Sequence=VSP_005191; Name=3; Synonyms=I-374; IsoId=P49768-3; Sequence=VSP_005191, VSP_005192; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=4; Synonyms=Minilin; IsoId=P49768-4; Sequence=VSP_007986, VSP_007987; Name=5; IsoId=P49768-5; Sequence=VSP_005192; Name=6; IsoId=P49768-6; Sequence=VSP_012288; Name=7; IsoId=P49768-7; Sequence=VSP_041440; 
# AltName	PSN1_HUMAN	Protein S182
# AltName	PSN1_HUMAN	Protein S182
# BioGrid	111642	85
# CCDS	CCDS9812	-. [P49768-1]
# CCDS	CCDS9813	-. [P49768-2]
# ChiTaRS	PSEN1	human
# DISEASE	PSN1_HUMAN	Acne inversa, familial, 3 (ACNINV3) [MIM 613737]  A chronic relapsing inflammatory disease of the hair follicles characterized by recurrent draining sinuses, painful skin abscesses, and disfiguring scars. Manifestations typically appear after puberty. {ECO 0000269|PubMed 20929727}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	PSN1_HUMAN	Alzheimer disease 3 (AD3) [MIM 607822]  A familial early- onset form of Alzheimer disease. Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death. {ECO 0000269|PubMed 10025789, ECO 0000269|PubMed 10090481, ECO 0000269|PubMed 10200054, ECO 0000269|PubMed 10208579, ECO 0000269|PubMed 10439444, ECO 0000269|PubMed 10441572, ECO 0000269|PubMed 10447269, ECO 0000269|PubMed 10533070, ECO 0000269|PubMed 10631141, ECO 0000269|PubMed 10644793, ECO 0000269|PubMed 11027672, ECO 0000269|PubMed 11524469, ECO 0000269|PubMed 11710891, ECO 0000269|PubMed 11920851, ECO 0000269|PubMed 12048239, ECO 0000269|PubMed 12484344, ECO 0000269|PubMed 12493737, ECO 0000269|PubMed 20460383, ECO 0000269|PubMed 22503161, ECO 0000269|PubMed 26145164, ECO 0000269|PubMed 26549787, ECO 0000269|PubMed 7550356, ECO 0000269|PubMed 7596406, ECO 0000269|PubMed 7651536, ECO 0000269|PubMed 8634711, ECO 0000269|PubMed 8634712, ECO 0000269|PubMed 8733303, ECO 0000269|PubMed 9172170, ECO 0000269|PubMed 9225696, ECO 0000269|PubMed 9298817, ECO 0000269|PubMed 9384602, ECO 0000269|PubMed 9507958, ECO 0000269|PubMed 9521423, ECO 0000269|PubMed 9719376, ECO 0000269|PubMed 9831473, ECO 0000269|PubMed 9833068, ECO 0000269|Ref.79}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	PSN1_HUMAN	Cardiomyopathy, dilated 1U (CMD1U) [MIM 613694]  A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. {ECO 0000269|PubMed 17186461}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	PSN1_HUMAN	Frontotemporal dementia (FTD) [MIM 600274]  A form of dementia characterized by pathologic finding of frontotemporal lobar degeneration, presenile dementia with behavioral changes, deterioration of cognitive capacities and loss of memory. In some cases, parkinsonian symptoms are prominent. Neuropathological changes include frontotemporal atrophy often associated with atrophy of the basal ganglia, substantia nigra, amygdala. In most cases, protein tau deposits are found in glial cells and/or neurons. {ECO 0000269|PubMed 11094121}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	PSN1_HUMAN	The PAL motif is required for normal active site conformation. 
# Ensembl	ENST00000324501	ENSP00000326366; ENSG00000080815. [P49768-1]
# Ensembl	ENST00000357710	ENSP00000350342; ENSG00000080815. [P49768-2]
# Ensembl	ENST00000394157	ENSP00000377712; ENSG00000080815. [P49768-4]
# Ensembl	ENST00000394164	ENSP00000377719; ENSG00000080815. [P49768-2]
# Ensembl	ENST00000553855	ENSP00000452242; ENSG00000080815. [P49768-5]
# Ensembl	ENST00000555386	ENSP00000450845; ENSG00000080815. [P49768-3]
# Ensembl	ENST00000557511	ENSP00000451429; ENSG00000080815. [P49768-6]
# ExpressionAtlas	P49768	baseline and differential
# FUNCTION	PSN1_HUMAN	Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis. {ECO 0000269|PubMed 10206644, ECO 0000269|PubMed 10545183, ECO 0000269|PubMed 10593990, ECO 0000269|PubMed 10811883, ECO 0000269|PubMed 10899933, ECO 0000269|PubMed 11226248, ECO 0000269|PubMed 15341515, ECO 0000269|PubMed 16305624}. 
# GO_component	GO:0000139	Golgi membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0000776	kinetochore; IDA:UniProtKB.
# GO_component	GO:0005634	nucleus; IDA:HPA.
# GO_component	GO:0005640	nuclear outer membrane; IDA:MGI.
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; IEA:Ensembl.
# GO_component	GO:0005765	lysosomal membrane; IEA:Ensembl.
# GO_component	GO:0005783	endoplasmic reticulum; IDA:HGNC.
# GO_component	GO:0005789	endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005790	smooth endoplasmic reticulum; IDA:UniProtKB.
# GO_component	GO:0005791	rough endoplasmic reticulum; IDA:UniProtKB.
# GO_component	GO:0005794	Golgi apparatus; IDA:UniProtKB.
# GO_component	GO:0005813	centrosome; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:HGNC.
# GO_component	GO:0009986	cell surface; IEA:UniProtKB-SubCell.
# GO_component	GO:0016020	membrane; IDA:MGI.
# GO_component	GO:0016021	integral component of membrane; TAS:UniProtKB.
# GO_component	GO:0016235	aggresome; IDA:UniProtKB.
# GO_component	GO:0030054	cell junction; IDA:HPA.
# GO_component	GO:0030424	axon; IEA:Ensembl.
# GO_component	GO:0030426	growth cone; IEA:Ensembl.
# GO_component	GO:0031410	cytoplasmic vesicle; IEA:Ensembl.
# GO_component	GO:0031594	neuromuscular junction; IEA:Ensembl.
# GO_component	GO:0031965	nuclear membrane; IDA:UniProtKB.
# GO_component	GO:0035253	ciliary rootlet; IEA:Ensembl.
# GO_component	GO:0043025	neuronal cell body; IEA:Ensembl.
# GO_component	GO:0043198	dendritic shaft; IEA:Ensembl.
# GO_component	GO:0045121	membrane raft; IDA:UniProtKB.
# GO_component	GO:0070765	gamma-secretase complex; IDA:UniProtKB.
# GO_component	GO:0098793	presynapse; IEA:GOC.
# GO_function	GO:0004175	endopeptidase activity; IDA:MGI.
# GO_function	GO:0004190	aspartic-type endopeptidase activity; IEA:InterPro.
# GO_function	GO:0005262	calcium channel activity; IMP:UniProtKB.
# GO_function	GO:0008013	beta-catenin binding; IPI:UniProtKB.
# GO_function	GO:0030165	PDZ domain binding; IPI:UniProtKB.
# GO_function	GO:0045296	cadherin binding; IBA:GO_Central.
# GO_process	GO:0000045	autophagosome assembly; IEA:Ensembl.
# GO_process	GO:0000122	negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
# GO_process	GO:0000186	activation of MAPKK activity; IEA:Ensembl.
# GO_process	GO:0001568	blood vessel development; IEA:Ensembl.
# GO_process	GO:0001708	cell fate specification; IEA:Ensembl.
# GO_process	GO:0001756	somitogenesis; IEA:Ensembl.
# GO_process	GO:0001764	neuron migration; IEA:Ensembl.
# GO_process	GO:0001921	positive regulation of receptor recycling; IEA:Ensembl.
# GO_process	GO:0001947	heart looping; IEA:Ensembl.
# GO_process	GO:0002244	hematopoietic progenitor cell differentiation; IEA:Ensembl.
# GO_process	GO:0002286	T cell activation involved in immune response; IEA:Ensembl.
# GO_process	GO:0003407	neural retina development; IEA:Ensembl.
# GO_process	GO:0006486	protein glycosylation; IEA:Ensembl.
# GO_process	GO:0006509	membrane protein ectodomain proteolysis; IDA:HGNC.
# GO_process	GO:0006839	mitochondrial transport; IEA:Ensembl.
# GO_process	GO:0006974	cellular response to DNA damage stimulus; IEA:Ensembl.
# GO_process	GO:0006979	response to oxidative stress; IEA:Ensembl.
# GO_process	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity; IEA:Ensembl.
# GO_process	GO:0007219	Notch signaling pathway; IEA:UniProtKB-KW.
# GO_process	GO:0007220	Notch receptor processing; TAS:HGNC.
# GO_process	GO:0007613	memory; IEA:Ensembl.
# GO_process	GO:0009791	post-embryonic development; IEA:Ensembl.
# GO_process	GO:0015031	protein transport; IEA:Ensembl.
# GO_process	GO:0015813	L-glutamate transport; IEA:Ensembl.
# GO_process	GO:0015871	choline transport; IEA:Ensembl.
# GO_process	GO:0016080	synaptic vesicle targeting; IEA:Ensembl.
# GO_process	GO:0016337	single organismal cell-cell adhesion; IMP:MGI.
# GO_process	GO:0016485	protein processing; IDA:HGNC.
# GO_process	GO:0021795	cerebral cortex cell migration; IEA:Ensembl.
# GO_process	GO:0021870	Cajal-Retzius cell differentiation; IEA:Ensembl.
# GO_process	GO:0021904	dorsal/ventral neural tube patterning; IEA:Ensembl.
# GO_process	GO:0030326	embryonic limb morphogenesis; IEA:Ensembl.
# GO_process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
# GO_process	GO:0032469	endoplasmic reticulum calcium ion homeostasis; IGI:UniProtKB.
# GO_process	GO:0034205	beta-amyloid formation; IEA:Ensembl.
# GO_process	GO:0035556	intracellular signal transduction; IEA:InterPro.
# GO_process	GO:0042325	regulation of phosphorylation; IDA:UniProtKB.
# GO_process	GO:0042987	amyloid precursor protein catabolic process; TAS:HGNC.
# GO_process	GO:0043011	myeloid dendritic cell differentiation; IEA:Ensembl.
# GO_process	GO:0043065	positive regulation of apoptotic process; IEA:Ensembl.
# GO_process	GO:0043066	negative regulation of apoptotic process; IDA:UniProtKB.
# GO_process	GO:0043085	positive regulation of catalytic activity; IDA:HGNC.
# GO_process	GO:0043393	regulation of protein binding; IEA:Ensembl.
# GO_process	GO:0043406	positive regulation of MAP kinase activity; IEA:Ensembl.
# GO_process	GO:0043524	negative regulation of neuron apoptotic process; IEA:Ensembl.
# GO_process	GO:0043589	skin morphogenesis; IEA:Ensembl.
# GO_process	GO:0045893	positive regulation of transcription, DNA-templated; IMP:CACAO.
# GO_process	GO:0048167	regulation of synaptic plasticity; IEA:Ensembl.
# GO_process	GO:0048538	thymus development; IEA:Ensembl.
# GO_process	GO:0048666	neuron development; IEA:Ensembl.
# GO_process	GO:0048705	skeletal system morphogenesis; IEA:Ensembl.
# GO_process	GO:0048854	brain morphogenesis; IEA:Ensembl.
# GO_process	GO:0050673	epithelial cell proliferation; IEA:Ensembl.
# GO_process	GO:0050771	negative regulation of axonogenesis; IEA:Ensembl.
# GO_process	GO:0050820	positive regulation of coagulation; IEA:Ensembl.
# GO_process	GO:0050852	T cell receptor signaling pathway; IEA:Ensembl.
# GO_process	GO:0051402	neuron apoptotic process; IEA:Ensembl.
# GO_process	GO:0051444	negative regulation of ubiquitin-protein transferase activity; IEA:Ensembl.
# GO_process	GO:0051563	smooth endoplasmic reticulum calcium ion homeostasis; IBA:GO_Central.
# GO_process	GO:0051966	regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
# GO_process	GO:0060070	canonical Wnt signaling pathway; IBA:GO_Central.
# GO_process	GO:0060075	regulation of resting membrane potential; IEA:Ensembl.
# GO_process	GO:0060999	positive regulation of dendritic spine development; IMP:CACAO.
# GO_process	GO:2000059	negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Ensembl.
# GO_process	GO:2001234	negative regulation of apoptotic signaling pathway; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005815	microtubule organizing center
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008233	peptidase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007155	cell adhesion
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0008219	cell death
# GOslim_process	GO:0008283	cell proliferation
# GOslim_process	GO:0022607	cellular component assembly
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048646	anatomical structure formation involved in morphogenesis
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0048870	cell motility
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0051604	protein maturation
# Genevisible	P49768	HS
# HGNC	HGNC:9508	PSEN1
# INTERACTION	PSN1_HUMAN	Q02410 APBA1; NbExp=4; IntAct=EBI-297277, EBI-368690; P98084 Apba2 (xeno); NbExp=2; IntAct=EBI-297277, EBI-81669; P05067 APP; NbExp=6; IntAct=EBI-297277, EBI-77613; P05067-4 APP; NbExp=3; IntAct=EBI-297277, EBI-302641; Q63053 Arc (xeno); NbExp=3; IntAct=EBI-2606326, EBI-5275794; Q16543 CDC37; NbExp=3; IntAct=EBI-297277, EBI-295634; P35222 CTNNB1; NbExp=2; IntAct=EBI-297277, EBI-491549; Q02248 Ctnnb1 (xeno); NbExp=3; IntAct=EBI-297277, EBI-397872; Q9BQ95 ECSIT; NbExp=4; IntAct=EBI-297277, EBI-712452; P14923 JUP; NbExp=4; IntAct=EBI-297277, EBI-702484; Q92542 NCSTN; NbExp=3; IntAct=EBI-297277, EBI-998440; P50502 ST13; NbExp=3; IntAct=EBI-297277, EBI-357285; P49755 TMED10; NbExp=3; IntAct=EBI-297277, EBI-998422; 
# IntAct	P49768	127
# InterPro	IPR001108	Peptidase_A22A
# InterPro	IPR002031	Pept_A22A_PS1
# InterPro	IPR006639	Preselin/SPP
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Brite	ko01002	 Peptidases
# KEGG_Disease	H00056	[Neurodegenerative disease] Alzheimer's disease (AD)
# KEGG_Disease	H00078	[Neurodegenerative disease] Frontotemporal dementia, chromosome 3-linked (FTD3)
# KEGG_Disease	H00294	[Cardiovascular disease] Dilated cardiomyopathy (DCM)
# KEGG_Disease	H00681	[Skin and connective tissue disease] Hidradenitis suppurativa
# KEGG_Pathway	ko04310	Wnt signaling pathway
# KEGG_Pathway	ko04330	Notch signaling pathway
# KEGG_Pathway	ko04722	Neurotrophin signaling pathway
# KEGG_Pathway	ko05010	Alzheimer's disease
# MIM	104311	gene
# MIM	600274	phenotype
# MIM	607822	phenotype
# MIM	613694	phenotype
# MIM	613737	phenotype
# Organism	PSN1_HUMAN	Homo sapiens (Human)
# Orphanet	100069	Semantic dementia
# Orphanet	100070	Progressive non-fluent aphasia
# Orphanet	1020	Early-onset autosomal dominant Alzheimer disease
# Orphanet	154	Familial isolated dilated cardiomyopathy
# Orphanet	275864	Behavioral variant of frontotemporal dementia
# Orphanet	387	Hidradenitis suppurativa
# PANTHER	PTHR10202	PTHR10202
# PANTHER	PTHR10202:SF18	PTHR10202:SF18
# PDB	2KR6	NMR; -; A=292-467
# PDB	4UIS	EM; 4.40 A; B=81-463
# PDB	5A63	EM; 3.40 A; B=1-467
# PDB	5FN2	EM; 4.20 A; B=1-467
# PDB	5FN3	EM; 4.10 A; B=1-467
# PDB	5FN4	EM; 4.00 A; B=1-467
# PDB	5FN5	EM; 4.30 A; B=1-467
# PIR	S58396	S58396
# PIR	S63683	S63683
# PIR	S63684	S63684
# PRINTS	PR01072	PRESENILIN
# PRINTS	PR01073	PRESENILIN1
# PTM	PSN1_HUMAN	After endoproteolysis, the C-terminal fragment (CTF) is phosphorylated on serine residues by PKA and/or PKC. Phosphorylation on Ser-346 inhibits endoproteolysis. {ECO 0000269|PubMed 14576165, ECO 0000269|PubMed 9144240}. 
# PTM	PSN1_HUMAN	Heterogeneous proteolytic processing generates N-terminal (NTF) and C-terminal (CTF) fragments of approximately 35 and 20 kDa, respectively. During apoptosis, the C-terminal fragment (CTF) is further cleaved by caspase-3 to produce the fragment, PS1- CTF12. {ECO 0000269|PubMed 9173929}. 
# Pfam	PF01080	Presenilin
# Proteomes	UP000005640	Chromosome 14
# Reactome	R-HSA-1474228	Degradation of the extracellular matrix
# Reactome	R-HSA-6798695	Neutrophil degranulation
# RecName	PSN1_HUMAN	Presenilin-1
# RecName	PSN1_HUMAN	Presenilin-1 CTF subunit
# RecName	PSN1_HUMAN	Presenilin-1 CTF subunit
# RecName	PSN1_HUMAN	Presenilin-1 CTF12
# RecName	PSN1_HUMAN	Presenilin-1 NTF subunit
# RecName	PSN1_HUMAN	Presenilin-1 NTF subunit
# RefSeq	NP_000012	NM_000021.3. [P49768-1]
# RefSeq	NP_015557	NM_007318.2. [P49768-2]
# RefSeq	XP_005267921	XM_005267864.2. [P49768-1]
# RefSeq	XP_005267923	XM_005267866.1. [P49768-2]
# RefSeq	XP_011535273	XM_011536971.2. [P49768-1]
# RefSeq	XP_011535274	XM_011536972.2. [P49768-1]
# RefSeq	XP_011535275	XM_011536973.1. [P49768-2]
# RefSeq	XP_011535276	XM_011536974.1. [P49768-2]
# SIMILARITY	Belongs to the peptidase A22A family. {ECO	0000305}. 
# SMART	SM00730	PSN
# SUBCELLULAR LOCATION	PSN1_HUMAN	Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell surface. Cell membrane {ECO 0000269|PubMed 21143716}. Note=Bound to NOTCH1 also at the cell surface. Colocalizes with CDH1/2 at sites of cell-cell contact. Colocalizes with CTNNB1 in the endoplasmic reticulum and the proximity of the plasma membrane. Also present in azurophil granules of neutrophils. Colocalizes with UBQLN1 in the cell membrane and in cytoplasmic juxtanuclear structures called aggresomes (PubMed 21143716). {ECO 0000269|PubMed 21143716}. 
# SUBUNIT	PSN1_HUMAN	Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity. Other components which are associated with the complex include SLC25A64, SLC5A7, PHB and PSEN1 isoform 3. Predominantly heterodimer of a N-terminal (NTF) and a C-terminal (CTF) endoproteolytical fragment. Associates with proteolytic processed C-terminal fragments C83 and C99 of the amyloid precursor protein (APP). Associates with NOTCH1. Associates with cadherin/catenin adhesion complexes through direct binding to CDH1 or CDH2. Interaction with CDH1 stabilizes the complex and stimulates cell-cell aggregation. Interaction with CDH2 is essential for trafficking of CDH2 from the endoplasmic reticulum to the plasma membrane. Interacts with CTNND2, CTNNB1, HERPUD1, FLNA, FLNB, MTCH1, PKP4 and PARL. Interacts through its N-terminus with isoform 3 of GFAP. Interacts with DOCK3 (By similarity). Interacts with isoform 1 and isoform 3 of UBQLN1. {ECO 0000250|UniProtKB P49769, ECO 0000269|PubMed 10037471, ECO 0000269|PubMed 10551805, ECO 0000269|PubMed 11226248, ECO 0000269|PubMed 11799129, ECO 0000269|PubMed 12058025, ECO 0000269|PubMed 12740439, ECO 0000269|PubMed 14515347, ECO 0000269|PubMed 15274632, ECO 0000269|PubMed 16126725, ECO 0000269|PubMed 21143716, ECO 0000269|PubMed 9437013, ECO 0000269|PubMed 9738936}. 
# TCDB	1.A.54.1	the presenilin er ca(2+) leak channel (presenilin) family
# TISSUE SPECIFICITY	PSN1_HUMAN	Expressed in a wide range of tissues including various regions of the brain, liver, spleen and lymph nodes. {ECO 0000269|PubMed 11987239, ECO 0000269|PubMed 8574969}. 
# UCSC	uc001xnq	human. [P49768-1]
# WEB RESOURCE	PSN1_HUMAN	Name=Alzheimer Research Forum; Note=Presenilins mutations; URL="http //www.alzforum.org/mutations/search?genes%255B%255D=348";
# eggNOG	ENOG410XPZD	LUCA
# eggNOG	KOG2736	Eukaryota
BLAST	swissprot:PSN1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:PSN1_HUMAN
BioCyc	ZFISH:ENSG00000080815-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000080815-MONOMER
COXPRESdb	5663	http://coxpresdb.jp/data/gene/5663.shtml
CleanEx	HS_PSEN1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_PSEN1
DIP	DIP-1134N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-1134N
DOI	10.1001/jama.286.18.2257	http://dx.doi.org/10.1001/jama.286.18.2257
DOI	10.1002/(SICI)1098-1004(1997)10:3<186::AID-HUMU2>3.3.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1997)10:3<186::AID-HUMU2>3.3.CO
DOI	10.1002/(SICI)1098-1004(1998)11:3<183::AID-HUMU1>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1998)11:3<183::AID-HUMU1>3.0.CO
DOI	10.1002/(SICI)1098-1004(1998)11:3<216::AID-HUMU6>3.3.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1998)11:3<216::AID-HUMU6>3.3.CO
DOI	10.1002/(SICI)1098-1004(1998)11:6<481::AID-HUMU13>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1998)11:6<481::AID-HUMU13>3.0.CO
DOI	10.1002/(SICI)1098-1004(1999)13:3<256::AID-HUMU11>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1999)13:3<256::AID-HUMU11>3.0.CO
DOI	10.1002/(SICI)1098-1004(1999)14:1<90::AID-HUMU19>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1999)14:1<90::AID-HUMU19>3.0.CO
DOI	10.1002/(SICI)1098-1004(199911)14:5<433::AID-HUMU10>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(199911)14:5<433::AID-HUMU10>3.0.CO
DOI	10.1002/ajmg.10250	http://dx.doi.org/10.1002/ajmg.10250
DOI	10.1002/ana.410420121	http://dx.doi.org/10.1002/ana.410420121
DOI	10.1002/ana.410440617	http://dx.doi.org/10.1002/ana.410440617
DOI	10.1002/ana.410440624	http://dx.doi.org/10.1002/ana.410440624
DOI	10.1002/jnr.10753	http://dx.doi.org/10.1002/jnr.10753
DOI	10.1006/bbrc.1996.6043	http://dx.doi.org/10.1006/bbrc.1996.6043
DOI	10.1006/bbrc.2000.3646	http://dx.doi.org/10.1006/bbrc.2000.3646
DOI	10.1006/bcmd.2002.0486	http://dx.doi.org/10.1006/bcmd.2002.0486
DOI	10.1006/nbdi.1997.0129	http://dx.doi.org/10.1006/nbdi.1997.0129
DOI	10.1007/s10048-002-0136-6	http://dx.doi.org/10.1007/s10048-002-0136-6
DOI	10.1016/0014-5793(96)00054-3	http://dx.doi.org/10.1016/0014-5793(96)00054-3
DOI	10.1016/0014-5793(96)00845-9	http://dx.doi.org/10.1016/0014-5793(96)00845-9
DOI	10.1016/0304-3940(96)12587-8	http://dx.doi.org/10.1016/0304-3940(96)12587-8
DOI	10.1016/S0014-5793(98)00886-2	http://dx.doi.org/10.1016/S0014-5793(98)00886-2
DOI	10.1016/j.ajhg.2008.04.014	http://dx.doi.org/10.1016/j.ajhg.2008.04.014
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1016/j.neulet.2015.11.004	http://dx.doi.org/10.1016/j.neulet.2015.11.004
DOI	10.1016/j.neurobiolaging.2012.02.020	http://dx.doi.org/10.1016/j.neurobiolaging.2012.02.020
DOI	10.1016/j.neurobiolaging.2015.06.007	http://dx.doi.org/10.1016/j.neurobiolaging.2015.06.007
DOI	10.1021/bi0494976	http://dx.doi.org/10.1021/bi0494976
DOI	10.1021/bi972106l	http://dx.doi.org/10.1021/bi972106l
DOI	10.1021/bi9914210	http://dx.doi.org/10.1021/bi9914210
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/19077	http://dx.doi.org/10.1038/19077
DOI	10.1038/375754a0	http://dx.doi.org/10.1038/375754a0
DOI	10.1038/376775a0	http://dx.doi.org/10.1038/376775a0
DOI	10.1038/nature01348	http://dx.doi.org/10.1038/nature01348
DOI	10.1038/nature09639	http://dx.doi.org/10.1038/nature09639
DOI	10.1038/ncb960	http://dx.doi.org/10.1038/ncb960
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/nm0296-224	http://dx.doi.org/10.1038/nm0296-224
DOI	10.1046/j.1471-4159.1999.0720999.x	http://dx.doi.org/10.1046/j.1471-4159.1999.0720999.x
DOI	10.1046/j.1471-4159.2000.0750583.x	http://dx.doi.org/10.1046/j.1471-4159.2000.0750583.x
DOI	10.1073/pnas.041603398	http://dx.doi.org/10.1073/pnas.041603398
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.100049897	http://dx.doi.org/10.1073/pnas.100049897
DOI	10.1073/pnas.1037392100	http://dx.doi.org/10.1073/pnas.1037392100
DOI	10.1073/pnas.112686799	http://dx.doi.org/10.1073/pnas.112686799
DOI	10.1073/pnas.94.10.5349	http://dx.doi.org/10.1073/pnas.94.10.5349
DOI	10.1074/jbc.274.46.32543	http://dx.doi.org/10.1074/jbc.274.46.32543
DOI	10.1074/jbc.274.51.36801	http://dx.doi.org/10.1074/jbc.274.51.36801
DOI	10.1074/jbc.M110.116962	http://dx.doi.org/10.1074/jbc.M110.116962
DOI	10.1074/jbc.M112121200	http://dx.doi.org/10.1074/jbc.M112121200
DOI	10.1074/jbc.M112372200	http://dx.doi.org/10.1074/jbc.M112372200
DOI	10.1074/jbc.M211827200	http://dx.doi.org/10.1074/jbc.M211827200
DOI	10.1074/jbc.M306653200	http://dx.doi.org/10.1074/jbc.M306653200
DOI	10.1074/jbc.M407898200	http://dx.doi.org/10.1074/jbc.M407898200
DOI	10.1074/jbc.M507503200	http://dx.doi.org/10.1074/jbc.M507503200
DOI	10.1086/302200	http://dx.doi.org/10.1086/302200
DOI	10.1086/302553	http://dx.doi.org/10.1086/302553
DOI	10.1086/302702	http://dx.doi.org/10.1086/302702
DOI	10.1086/509900	http://dx.doi.org/10.1086/509900
DOI	10.1093/hmg/4.12.2363	http://dx.doi.org/10.1093/hmg/4.12.2363
DOI	10.1093/hmg/4.12.2373	http://dx.doi.org/10.1093/hmg/4.12.2373
DOI	10.1093/hmg/7.1.43	http://dx.doi.org/10.1093/hmg/7.1.43
DOI	10.1097/00001756-199704140-00043	http://dx.doi.org/10.1097/00001756-199704140-00043
DOI	10.1097/00001756-199801260-00008	http://dx.doi.org/10.1097/00001756-199801260-00008
DOI	10.1097/00001756-199810050-00034	http://dx.doi.org/10.1097/00001756-199810050-00034
DOI	10.1097/00001756-199902250-00011	http://dx.doi.org/10.1097/00001756-199902250-00011
DOI	10.1097/00001756-199908020-00006	http://dx.doi.org/10.1097/00001756-199908020-00006
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1471-4159.2004.02596.x	http://dx.doi.org/10.1111/j.1471-4159.2004.02596.x
DOI	10.1111/j.1471-4159.2005.03548.x	http://dx.doi.org/10.1111/j.1471-4159.2005.03548.x
DOI	10.1111/j.1600-0854.2010.01149.x	http://dx.doi.org/10.1111/j.1600-0854.2010.01149.x
DOI	10.1126/science.1196284	http://dx.doi.org/10.1126/science.1196284
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1136/jmg.35.8.672	http://dx.doi.org/10.1136/jmg.35.8.672
DOI	10.1136/jnnp.68.2.220	http://dx.doi.org/10.1136/jnnp.68.2.220
DOI	10.1186/gb-2004-5-2-r8	http://dx.doi.org/10.1186/gb-2004-5-2-r8
DOI	10.1212/WNL.52.3.566	http://dx.doi.org/10.1212/WNL.52.3.566
DOI	10.1212/WNL.55.10.1577	http://dx.doi.org/10.1212/WNL.55.10.1577
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EC_number	EC:3.4.23.-	http://www.genome.jp/dbget-bin/www_bget?EC:3.4.23.-
EMBL	AC004858	http://www.ebi.ac.uk/ena/data/view/AC004858
EMBL	AC004858	http://www.ebi.ac.uk/ena/data/view/AC004858
EMBL	AF109907	http://www.ebi.ac.uk/ena/data/view/AF109907
EMBL	AF416717	http://www.ebi.ac.uk/ena/data/view/AF416717
EMBL	AJ008005	http://www.ebi.ac.uk/ena/data/view/AJ008005
EMBL	AK312531	http://www.ebi.ac.uk/ena/data/view/AK312531
EMBL	BC011729	http://www.ebi.ac.uk/ena/data/view/BC011729
EMBL	CH471061	http://www.ebi.ac.uk/ena/data/view/CH471061
EMBL	D84149	http://www.ebi.ac.uk/ena/data/view/D84149
EMBL	L42110	http://www.ebi.ac.uk/ena/data/view/L42110
EMBL	L76517	http://www.ebi.ac.uk/ena/data/view/L76517
EMBL	L76519	http://www.ebi.ac.uk/ena/data/view/L76519
EMBL	L76520	http://www.ebi.ac.uk/ena/data/view/L76520
EMBL	L76521	http://www.ebi.ac.uk/ena/data/view/L76521
EMBL	L76522	http://www.ebi.ac.uk/ena/data/view/L76522
EMBL	L76523	http://www.ebi.ac.uk/ena/data/view/L76523
EMBL	L76524	http://www.ebi.ac.uk/ena/data/view/L76524
EMBL	L76525	http://www.ebi.ac.uk/ena/data/view/L76525
EMBL	L76526	http://www.ebi.ac.uk/ena/data/view/L76526
EMBL	L76527	http://www.ebi.ac.uk/ena/data/view/L76527
EMBL	L76528	http://www.ebi.ac.uk/ena/data/view/L76528
EMBL	U40379	http://www.ebi.ac.uk/ena/data/view/U40379
EMBL	U40380	http://www.ebi.ac.uk/ena/data/view/U40380
ENZYME	3.4.23.-	http://enzyme.expasy.org/EC/3.4.23.-
Ensembl	ENST00000324501	http://www.ensembl.org/id/ENST00000324501
Ensembl	ENST00000357710	http://www.ensembl.org/id/ENST00000357710
Ensembl	ENST00000394157	http://www.ensembl.org/id/ENST00000394157
Ensembl	ENST00000394164	http://www.ensembl.org/id/ENST00000394164
Ensembl	ENST00000553855	http://www.ensembl.org/id/ENST00000553855
Ensembl	ENST00000555386	http://www.ensembl.org/id/ENST00000555386
Ensembl	ENST00000557511	http://www.ensembl.org/id/ENST00000557511
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0000776	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000776
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005640	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005640
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GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005790
GO_component	GO:0005791	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005791
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005813
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016235	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016235
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030424	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030424
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GO_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GO_component	GO:0031594	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031594
GO_component	GO:0031965	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031965
GO_component	GO:0035253	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035253
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0043198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043198
GO_component	GO:0045121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045121
GO_component	GO:0070765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070765
GO_component	GO:0098793	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098793
GO_function	GO:0004175	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004175
GO_function	GO:0004190	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004190
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0008013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008013
GO_function	GO:0030165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030165
GO_function	GO:0045296	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045296
GO_process	GO:0000045	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000045
GO_process	GO:0000122	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000122
GO_process	GO:0000186	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000186
GO_process	GO:0001568	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001568
GO_process	GO:0001708	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001708
GO_process	GO:0001756	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001756
GO_process	GO:0001764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001764
GO_process	GO:0001921	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001921
GO_process	GO:0001947	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001947
GO_process	GO:0002244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002244
GO_process	GO:0002286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002286
GO_process	GO:0003407	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003407
GO_process	GO:0006486	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006486
GO_process	GO:0006509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006509
GO_process	GO:0006839	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006839
GO_process	GO:0006974	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974
GO_process	GO:0006979	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979
GO_process	GO:0007175	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007175
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GO_process	GO:0009791	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009791
GO_process	GO:0015031	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031
GO_process	GO:0015813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015813
GO_process	GO:0015871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015871
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GO_process	GO:0016337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016337
GO_process	GO:0016485	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016485
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GO_process	GO:0030326	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030326
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GO_process	GO:0032469	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032469
GO_process	GO:0034205	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034205
GO_process	GO:0035556	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035556
GO_process	GO:0042325	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042325
GO_process	GO:0042987	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042987
GO_process	GO:0043011	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043011
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GO_process	GO:0043085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043085
GO_process	GO:0043393	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043393
GO_process	GO:0043406	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043406
GO_process	GO:0043524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043524
GO_process	GO:0043589	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043589
GO_process	GO:0045893	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893
GO_process	GO:0048167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048167
GO_process	GO:0048538	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048538
GO_process	GO:0048666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048666
GO_process	GO:0048705	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048705
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GO_process	GO:0050673	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050673
GO_process	GO:0050771	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050771
GO_process	GO:0050820	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050820
GO_process	GO:0050852	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050852
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GO_process	GO:0051444	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051444
GO_process	GO:0051563	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051563
GO_process	GO:0051966	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051966
GO_process	GO:0060070	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060070
GO_process	GO:0060075	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060075
GO_process	GO:0060999	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060999
GO_process	GO:2000059	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000059
GO_process	GO:2001234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001234
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005815	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005815
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008233	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0008219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219
GOslim_process	GO:0008283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008283
GOslim_process	GO:0022607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
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GOslim_process	GO:0048646	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048646
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0051604	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604
GeneCards	PSEN1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=PSEN1
GeneID	5663	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5663
GeneTree	ENSGT00390000016593	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000016593
HGNC	HGNC:9508	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:9508
HOVERGEN	HBG011375	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG011375&db=HOVERGEN
HPA	CAB006844	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB006844
HPA	HPA030760	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA030760
HPA	HPA067496	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA067496
InParanoid	P49768	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P49768
IntAct	P49768	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P49768*
IntEnz	3.4.23	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.23
InterPro	IPR001108	http://www.ebi.ac.uk/interpro/entry/IPR001108
InterPro	IPR002031	http://www.ebi.ac.uk/interpro/entry/IPR002031
InterPro	IPR006639	http://www.ebi.ac.uk/interpro/entry/IPR006639
Jabion	5663	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=5663
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Brite	ko01002	http://www.genome.jp/dbget-bin/www_bget?ko01002
KEGG_Disease	H00056	http://www.genome.jp/dbget-bin/www_bget?H00056
KEGG_Disease	H00078	http://www.genome.jp/dbget-bin/www_bget?H00078
KEGG_Disease	H00294	http://www.genome.jp/dbget-bin/www_bget?H00294
KEGG_Disease	H00681	http://www.genome.jp/dbget-bin/www_bget?H00681
KEGG_Gene	hsa:5663	http://www.genome.jp/dbget-bin/www_bget?hsa:5663
KEGG_Orthology	KO:K04505	http://www.genome.jp/dbget-bin/www_bget?KO:K04505
KEGG_Pathway	ko04310	http://www.genome.jp/kegg-bin/show_pathway?ko04310
KEGG_Pathway	ko04330	http://www.genome.jp/kegg-bin/show_pathway?ko04330
KEGG_Pathway	ko04722	http://www.genome.jp/kegg-bin/show_pathway?ko04722
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
MIM	104311	http://www.ncbi.nlm.nih.gov/omim/104311
MIM	600274	http://www.ncbi.nlm.nih.gov/omim/600274
MIM	607822	http://www.ncbi.nlm.nih.gov/omim/607822
MIM	613694	http://www.ncbi.nlm.nih.gov/omim/613694
MIM	613737	http://www.ncbi.nlm.nih.gov/omim/613737
MINT	MINT-88325	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-88325
OMA	NTNDNRE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NTNDNRE
Orphanet	100069	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=100069
Orphanet	100070	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=100070
Orphanet	1020	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1020
Orphanet	154	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=154
Orphanet	275864	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=275864
Orphanet	387	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=387
OrthoDB	EOG091G0C72	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0C72
PANTHER	PTHR10202	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10202
PANTHER	PTHR10202:SF18	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10202:SF18
PDB	2KR6	http://www.ebi.ac.uk/pdbe-srv/view/entry/2KR6
PDB	4UIS	http://www.ebi.ac.uk/pdbe-srv/view/entry/4UIS
PDB	5A63	http://www.ebi.ac.uk/pdbe-srv/view/entry/5A63
PDB	5FN2	http://www.ebi.ac.uk/pdbe-srv/view/entry/5FN2
PDB	5FN3	http://www.ebi.ac.uk/pdbe-srv/view/entry/5FN3
PDB	5FN4	http://www.ebi.ac.uk/pdbe-srv/view/entry/5FN4
PDB	5FN5	http://www.ebi.ac.uk/pdbe-srv/view/entry/5FN5
PDBsum	2KR6	http://www.ebi.ac.uk/pdbsum/2KR6
PDBsum	4UIS	http://www.ebi.ac.uk/pdbsum/4UIS
PDBsum	5A63	http://www.ebi.ac.uk/pdbsum/5A63
PDBsum	5FN2	http://www.ebi.ac.uk/pdbsum/5FN2
PDBsum	5FN3	http://www.ebi.ac.uk/pdbsum/5FN3
PDBsum	5FN4	http://www.ebi.ac.uk/pdbsum/5FN4
PDBsum	5FN5	http://www.ebi.ac.uk/pdbsum/5FN5
PRINTS	PR01072	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01072
PRINTS	PR01073	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01073
PSORT	swissprot:PSN1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:PSN1_HUMAN
PSORT-B	swissprot:PSN1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:PSN1_HUMAN
PSORT2	swissprot:PSN1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:PSN1_HUMAN
Pfam	PF01080	http://pfam.xfam.org/family/PF01080
PharmGKB	PA33855	http://www.pharmgkb.org/do/serve?objId=PA33855&objCls=Gene
Phobius	swissprot:PSN1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:PSN1_HUMAN
PhylomeDB	P49768	http://phylomedb.org/?seqid=P49768
ProteinModelPortal	P49768	http://www.proteinmodelportal.org/query/uniprot/P49768
PubMed	10025789	http://www.ncbi.nlm.nih.gov/pubmed/10025789
PubMed	10037471	http://www.ncbi.nlm.nih.gov/pubmed/10037471
PubMed	10090481	http://www.ncbi.nlm.nih.gov/pubmed/10090481
PubMed	10200054	http://www.ncbi.nlm.nih.gov/pubmed/10200054
PubMed	10206644	http://www.ncbi.nlm.nih.gov/pubmed/10206644
PubMed	10208579	http://www.ncbi.nlm.nih.gov/pubmed/10208579
PubMed	10439444	http://www.ncbi.nlm.nih.gov/pubmed/10439444
PubMed	10441572	http://www.ncbi.nlm.nih.gov/pubmed/10441572
PubMed	10447269	http://www.ncbi.nlm.nih.gov/pubmed/10447269
PubMed	10533070	http://www.ncbi.nlm.nih.gov/pubmed/10533070
PubMed	10545183	http://www.ncbi.nlm.nih.gov/pubmed/10545183
PubMed	10551805	http://www.ncbi.nlm.nih.gov/pubmed/10551805
PubMed	10593990	http://www.ncbi.nlm.nih.gov/pubmed/10593990
PubMed	10631141	http://www.ncbi.nlm.nih.gov/pubmed/10631141
PubMed	10644793	http://www.ncbi.nlm.nih.gov/pubmed/10644793
PubMed	10811883	http://www.ncbi.nlm.nih.gov/pubmed/10811883
PubMed	10899933	http://www.ncbi.nlm.nih.gov/pubmed/10899933
PubMed	11027672	http://www.ncbi.nlm.nih.gov/pubmed/11027672
PubMed	11094121	http://www.ncbi.nlm.nih.gov/pubmed/11094121
PubMed	11226248	http://www.ncbi.nlm.nih.gov/pubmed/11226248
PubMed	11524469	http://www.ncbi.nlm.nih.gov/pubmed/11524469
PubMed	11710891	http://www.ncbi.nlm.nih.gov/pubmed/11710891
PubMed	11799129	http://www.ncbi.nlm.nih.gov/pubmed/11799129
PubMed	11920851	http://www.ncbi.nlm.nih.gov/pubmed/11920851
PubMed	11987239	http://www.ncbi.nlm.nih.gov/pubmed/11987239
PubMed	12048239	http://www.ncbi.nlm.nih.gov/pubmed/12048239
PubMed	12058025	http://www.ncbi.nlm.nih.gov/pubmed/12058025
PubMed	12484344	http://www.ncbi.nlm.nih.gov/pubmed/12484344
PubMed	12493737	http://www.ncbi.nlm.nih.gov/pubmed/12493737
PubMed	12508121	http://www.ncbi.nlm.nih.gov/pubmed/12508121
PubMed	12679784	http://www.ncbi.nlm.nih.gov/pubmed/12679784
PubMed	12740439	http://www.ncbi.nlm.nih.gov/pubmed/12740439
PubMed	14515347	http://www.ncbi.nlm.nih.gov/pubmed/14515347
PubMed	14576165	http://www.ncbi.nlm.nih.gov/pubmed/14576165
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	14759258	http://www.ncbi.nlm.nih.gov/pubmed/14759258
PubMed	15274632	http://www.ncbi.nlm.nih.gov/pubmed/15274632
PubMed	15341515	http://www.ncbi.nlm.nih.gov/pubmed/15341515
PubMed	15385547	http://www.ncbi.nlm.nih.gov/pubmed/15385547
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16126725	http://www.ncbi.nlm.nih.gov/pubmed/16126725
PubMed	16305624	http://www.ncbi.nlm.nih.gov/pubmed/16305624
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	17186461	http://www.ncbi.nlm.nih.gov/pubmed/17186461
PubMed	18485326	http://www.ncbi.nlm.nih.gov/pubmed/18485326
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	20460383	http://www.ncbi.nlm.nih.gov/pubmed/20460383
PubMed	20929727	http://www.ncbi.nlm.nih.gov/pubmed/20929727
PubMed	21143716	http://www.ncbi.nlm.nih.gov/pubmed/21143716
PubMed	21248752	http://www.ncbi.nlm.nih.gov/pubmed/21248752
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	22503161	http://www.ncbi.nlm.nih.gov/pubmed/22503161
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	26145164	http://www.ncbi.nlm.nih.gov/pubmed/26145164
PubMed	26549787	http://www.ncbi.nlm.nih.gov/pubmed/26549787
PubMed	7550356	http://www.ncbi.nlm.nih.gov/pubmed/7550356
PubMed	7596406	http://www.ncbi.nlm.nih.gov/pubmed/7596406
PubMed	7651536	http://www.ncbi.nlm.nih.gov/pubmed/7651536
PubMed	8574969	http://www.ncbi.nlm.nih.gov/pubmed/8574969
PubMed	8634711	http://www.ncbi.nlm.nih.gov/pubmed/8634711
PubMed	8634712	http://www.ncbi.nlm.nih.gov/pubmed/8634712
PubMed	8641442	http://www.ncbi.nlm.nih.gov/pubmed/8641442
PubMed	8733303	http://www.ncbi.nlm.nih.gov/pubmed/8733303
PubMed	8804415	http://www.ncbi.nlm.nih.gov/pubmed/8804415
PubMed	8875251	http://www.ncbi.nlm.nih.gov/pubmed/8875251
PubMed	9070286	http://www.ncbi.nlm.nih.gov/pubmed/9070286
PubMed	9144240	http://www.ncbi.nlm.nih.gov/pubmed/9144240
PubMed	9172170	http://www.ncbi.nlm.nih.gov/pubmed/9172170
PubMed	9173929	http://www.ncbi.nlm.nih.gov/pubmed/9173929
PubMed	9225696	http://www.ncbi.nlm.nih.gov/pubmed/9225696
PubMed	9298817	http://www.ncbi.nlm.nih.gov/pubmed/9298817
PubMed	9384602	http://www.ncbi.nlm.nih.gov/pubmed/9384602
PubMed	9437013	http://www.ncbi.nlm.nih.gov/pubmed/9437013
PubMed	9485372	http://www.ncbi.nlm.nih.gov/pubmed/9485372
PubMed	9507958	http://www.ncbi.nlm.nih.gov/pubmed/9507958
PubMed	9521418	http://www.ncbi.nlm.nih.gov/pubmed/9521418
PubMed	9521423	http://www.ncbi.nlm.nih.gov/pubmed/9521423
PubMed	9719376	http://www.ncbi.nlm.nih.gov/pubmed/9719376
PubMed	9738936	http://www.ncbi.nlm.nih.gov/pubmed/9738936
PubMed	9831473	http://www.ncbi.nlm.nih.gov/pubmed/9831473
PubMed	9833068	http://www.ncbi.nlm.nih.gov/pubmed/9833068
PubMed	9851443	http://www.ncbi.nlm.nih.gov/pubmed/9851443
PubMed	9851450	http://www.ncbi.nlm.nih.gov/pubmed/9851450
PubMed	9915968	http://www.ncbi.nlm.nih.gov/pubmed/9915968
Reactome	R-HSA-1474228	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1474228
Reactome	R-HSA-6798695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6798695
RefSeq	NP_000012	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000012
RefSeq	NP_015557	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_015557
RefSeq	XP_005267921	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005267921
RefSeq	XP_005267923	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005267923
RefSeq	XP_011535273	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011535273
RefSeq	XP_011535274	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011535274
RefSeq	XP_011535275	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011535275
RefSeq	XP_011535276	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011535276
SMART	SM00730	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00730
SMR	P49768	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P49768
STRING	9606.ENSP00000326366	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000326366&targetmode=cogs
TCDB	1.A.54.1	http://www.tcdb.org/search/result.php?tc=1.A.54.1
UCSC	uc001xnq	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001xnq&org=rat
UniGene	Hs.3260	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.3260
UniProtKB	PSN1_HUMAN	http://www.uniprot.org/uniprot/PSN1_HUMAN
UniProtKB-AC	P49768	http://www.uniprot.org/uniprot/P49768
charge	swissprot:PSN1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:PSN1_HUMAN
eggNOG	ENOG410XPZD	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPZD
eggNOG	KOG2736	http://eggnogapi.embl.de/nog_data/html/tree/KOG2736
epestfind	swissprot:PSN1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:PSN1_HUMAN
garnier	swissprot:PSN1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:PSN1_HUMAN
helixturnhelix	swissprot:PSN1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:PSN1_HUMAN
hmoment	swissprot:PSN1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:PSN1_HUMAN
iep	swissprot:PSN1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:PSN1_HUMAN
inforesidue	swissprot:PSN1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:PSN1_HUMAN
neXtProt	NX_P49768	http://www.nextprot.org/db/entry/NX_P49768
octanol	swissprot:PSN1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:PSN1_HUMAN
pepcoil	swissprot:PSN1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:PSN1_HUMAN
pepdigest	swissprot:PSN1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:PSN1_HUMAN
pepinfo	swissprot:PSN1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:PSN1_HUMAN
pepnet	swissprot:PSN1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:PSN1_HUMAN
pepstats	swissprot:PSN1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:PSN1_HUMAN
pepwheel	swissprot:PSN1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:PSN1_HUMAN
pepwindow	swissprot:PSN1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:PSN1_HUMAN
sigcleave	swissprot:PSN1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:PSN1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	APOL1_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=A; IsoId=O14791-1; Sequence=Displayed; Note=Major isoform.; Name=2; Synonyms=B; IsoId=O14791-2; Sequence=VSP_000292; Name=3; IsoId=O14791-3; Sequence=VSP_045077; Note=No experimental confirmation available.; 
# AltName	APOL1_HUMAN	Apolipoprotein L
# AltName	APOL1_HUMAN	Apolipoprotein L-I
# BioGrid	114112	2
# CCDS	CCDS13925	-. [O14791-2]
# CCDS	CCDS13926	-. [O14791-1]
# CCDS	CCDS46702	-. [O14791-3]
# ChiTaRS	APOL1	human
# DISEASE	APOL1_HUMAN	Focal segmental glomerulosclerosis 4 (FSGS4) [MIM 612551]  A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. {ECO 0000269|PubMed 20635188, ECO 0000269|PubMed 20647424}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000319136	ENSP00000317674; ENSG00000100342. [O14791-2]
# Ensembl	ENST00000397278	ENSP00000380448; ENSG00000100342. [O14791-1]
# Ensembl	ENST00000397279	ENSP00000380449; ENSG00000100342. [O14791-1]
# Ensembl	ENST00000422706	ENSP00000411507; ENSG00000100342. [O14791-1]
# Ensembl	ENST00000426053	ENSP00000388477; ENSG00000100342. [O14791-3]
# ExpressionAtlas	O14791	baseline and differential
# FUNCTION	APOL1_HUMAN	May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. 
# GO_component	GO:0005576	extracellular region; TAS:Reactome.
# GO_component	GO:0005615	extracellular space; IDA:BHF-UCL.
# GO_component	GO:0031224	intrinsic component of membrane; IC:BHF-UCL.
# GO_component	GO:0034361	very-low-density lipoprotein particle; IDA:BHF-UCL.
# GO_component	GO:0034364	high-density lipoprotein particle; IDA:BHF-UCL.
# GO_component	GO:0072562	blood microparticle; IDA:UniProtKB.
# GO_function	GO:0005254	chloride channel activity; IDA:BHF-UCL.
# GO_function	GO:0008289	lipid binding; IDA:BHF-UCL.
# GO_process	GO:0006869	lipid transport; IEA:UniProtKB-KW.
# GO_process	GO:0006898	receptor-mediated endocytosis; TAS:Reactome.
# GO_process	GO:0008203	cholesterol metabolic process; IEA:UniProtKB-KW.
# GO_process	GO:0019835	cytolysis; IDA:BHF-UCL.
# GO_process	GO:0031640	killing of cells of other organism; IDA:BHF-UCL.
# GO_process	GO:0042157	lipoprotein metabolic process; IEA:InterPro.
# GO_process	GO:0045087	innate immune response; IDA:BHF-UCL.
# GO_process	GO:1902476	chloride transmembrane transport; IMP:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005576	extracellular region
# GOslim_component	GO:0005615	extracellular space
# GOslim_function	GO:0008289	lipid binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	O14791	HS
# HGNC	HGNC:618	APOL1
# INTERACTION	APOL1_HUMAN	Q9UJX2 CDC23; NbExp=3; IntAct=EBI-1221934, EBI-396137; 
# IntAct	O14791	2
# InterPro	IPR008405	ApoL
# KEGG_Disease	H00626	[Kidney disease] Focal segmental glomerulosclerosis
# MIM	603743	gene
# MIM	612551	phenotype
# Organism	APOL1_HUMAN	Homo sapiens (Human)
# Orphanet	93218	Sporadic idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis
# PANTHER	PTHR14096	PTHR14096
# PTM	APOL1_HUMAN	Phosphorylated by FAM20C in the extracellular medium. {ECO 0000269|PubMed 26091039}. 
# Pfam	PF05461	ApoL
# Proteomes	UP000005640	Chromosome 22
# Reactome	R-HSA-2168880	Scavenging of heme from plasma
# RecName	APOL1_HUMAN	Apolipoprotein L1
# RefSeq	NP_001130012	NM_001136540.1. [O14791-1]
# RefSeq	NP_001130013	NM_001136541.1. [O14791-3]
# RefSeq	NP_003652	NM_003661.3. [O14791-1]
# RefSeq	XP_005261853	XM_005261796.3. [O14791-3]
# SEQUENCE CAUTION	Sequence=AAB81218.2; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the apolipoprotein L family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	APOL1_HUMAN	Secreted. 
# SUBUNIT	APOL1_HUMAN	In plasma, interacts with APOA1 and mainly associated with large high density lipoprotein particles. 
# TISSUE SPECIFICITY	APOL1_HUMAN	Plasma. Found on APOA-I-containing high density lipoprotein (HDL3). Expressed in pancreas, lung, prostate, liver, placenta and spleen. 
# UCSC	uc003ape	human. [O14791-1]
# eggNOG	ENOG410KC8P	Eukaryota
# eggNOG	ENOG4110P7Y	LUCA
BLAST	swissprot:APOL1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:APOL1_HUMAN
BioCyc	ZFISH:ENSG00000100342-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000100342-MONOMER
COXPRESdb	8542	http://coxpresdb.jp/data/gene/8542.shtml
CleanEx	HS_APOL1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_APOL1
DOI	10.1006/geno.2001.6534	http://dx.doi.org/10.1006/geno.2001.6534
DOI	10.1006/geno.2002.6729	http://dx.doi.org/10.1006/geno.2002.6729
DOI	10.1007/s00439-010-0861-0	http://dx.doi.org/10.1007/s00439-010-0861-0
DOI	10.1016/j.cell.2015.05.028	http://dx.doi.org/10.1016/j.cell.2015.05.028
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr0502065	http://dx.doi.org/10.1021/pr0502065
DOI	10.1038/990031	http://dx.doi.org/10.1038/990031
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.272.41.25576	http://dx.doi.org/10.1074/jbc.272.41.25576
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1126/science.1193032	http://dx.doi.org/10.1126/science.1193032
EMBL	AF019225	http://www.ebi.ac.uk/ena/data/view/AF019225
EMBL	AF305224	http://www.ebi.ac.uk/ena/data/view/AF305224
EMBL	AF305428	http://www.ebi.ac.uk/ena/data/view/AF305428
EMBL	AF323540	http://www.ebi.ac.uk/ena/data/view/AF323540
EMBL	AF323543	http://www.ebi.ac.uk/ena/data/view/AF323543
EMBL	AF323544	http://www.ebi.ac.uk/ena/data/view/AF323544
EMBL	AF323545	http://www.ebi.ac.uk/ena/data/view/AF323545
EMBL	AF323546	http://www.ebi.ac.uk/ena/data/view/AF323546
EMBL	AF323547	http://www.ebi.ac.uk/ena/data/view/AF323547
EMBL	AF323548	http://www.ebi.ac.uk/ena/data/view/AF323548
EMBL	AK300454	http://www.ebi.ac.uk/ena/data/view/AK300454
EMBL	BC143039	http://www.ebi.ac.uk/ena/data/view/BC143039
EMBL	Z82215	http://www.ebi.ac.uk/ena/data/view/Z82215
EMBL	Z82215	http://www.ebi.ac.uk/ena/data/view/Z82215
Ensembl	ENST00000319136	http://www.ensembl.org/id/ENST00000319136
Ensembl	ENST00000397278	http://www.ensembl.org/id/ENST00000397278
Ensembl	ENST00000397279	http://www.ensembl.org/id/ENST00000397279
Ensembl	ENST00000422706	http://www.ensembl.org/id/ENST00000422706
Ensembl	ENST00000426053	http://www.ensembl.org/id/ENST00000426053
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005576	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576
GO_component	GO:0005615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005615
GO_component	GO:0031224	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031224
GO_component	GO:0034361	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034361
GO_component	GO:0034364	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034364
GO_component	GO:0072562	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072562
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GO_process	GO:0006869	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006869
GO_process	GO:0006898	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006898
GO_process	GO:0008203	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008203
GO_process	GO:0019835	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019835
GO_process	GO:0031640	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031640
GO_process	GO:0042157	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042157
GO_process	GO:0045087	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045087
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005576	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576
GOslim_component	GO:0005615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005615
GOslim_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	APOL1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=APOL1
GeneID	8542	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8542
GeneTree	ENSGT00510000046700	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00510000046700
H-InvDB	HIX0016423	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0016423
HGNC	HGNC:618	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:618
HOGENOM	HOG000294132	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294132&db=HOGENOM6
HOVERGEN	HBG074468	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG074468&db=HOVERGEN
HPA	CAB056156	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB056156
HPA	HPA018885	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA018885
InParanoid	O14791	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O14791
IntAct	O14791	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O14791*
InterPro	IPR008405	http://www.ebi.ac.uk/interpro/entry/IPR008405
Jabion	8542	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=8542
KEGG_Disease	H00626	http://www.genome.jp/dbget-bin/www_bget?H00626
KEGG_Gene	hsa:8542	http://www.genome.jp/dbget-bin/www_bget?hsa:8542
KEGG_Orthology	KO:K14480	http://www.genome.jp/dbget-bin/www_bget?KO:K14480
MIM	603743	http://www.ncbi.nlm.nih.gov/omim/603743
MIM	612551	http://www.ncbi.nlm.nih.gov/omim/612551
OMA	VQKVHKG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VQKVHKG
Orphanet	93218	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=93218
OrthoDB	EOG091G0BJK	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0BJK
PANTHER	PTHR14096	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14096
PSORT	swissprot:APOL1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:APOL1_HUMAN
PSORT-B	swissprot:APOL1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:APOL1_HUMAN
PSORT2	swissprot:APOL1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:APOL1_HUMAN
Pfam	PF05461	http://pfam.xfam.org/family/PF05461
PharmGKB	PA24904	http://www.pharmgkb.org/do/serve?objId=PA24904&objCls=Gene
Phobius	swissprot:APOL1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:APOL1_HUMAN
PhylomeDB	O14791	http://phylomedb.org/?seqid=O14791
ProteinModelPortal	O14791	http://www.proteinmodelportal.org/query/uniprot/O14791
PubMed	10591208	http://www.ncbi.nlm.nih.gov/pubmed/10591208
PubMed	11290834	http://www.ncbi.nlm.nih.gov/pubmed/11290834
PubMed	11374903	http://www.ncbi.nlm.nih.gov/pubmed/11374903
PubMed	11944986	http://www.ncbi.nlm.nih.gov/pubmed/11944986
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16335952	http://www.ncbi.nlm.nih.gov/pubmed/16335952
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	20635188	http://www.ncbi.nlm.nih.gov/pubmed/20635188
PubMed	20647424	http://www.ncbi.nlm.nih.gov/pubmed/20647424
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	26091039	http://www.ncbi.nlm.nih.gov/pubmed/26091039
PubMed	9325276	http://www.ncbi.nlm.nih.gov/pubmed/9325276
Reactome	R-HSA-2168880	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2168880
RefSeq	NP_001130012	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001130012
RefSeq	NP_001130013	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001130013
RefSeq	NP_003652	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003652
RefSeq	XP_005261853	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005261853
STRING	9606.ENSP00000317674	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000317674&targetmode=cogs
UCSC	uc003ape	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ape&org=rat
UniGene	Hs.114309	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.114309
UniProtKB	APOL1_HUMAN	http://www.uniprot.org/uniprot/APOL1_HUMAN
UniProtKB-AC	O14791	http://www.uniprot.org/uniprot/O14791
charge	swissprot:APOL1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:APOL1_HUMAN
eggNOG	ENOG410KC8P	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410KC8P
eggNOG	ENOG4110P7Y	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110P7Y
epestfind	swissprot:APOL1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:APOL1_HUMAN
garnier	swissprot:APOL1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:APOL1_HUMAN
helixturnhelix	swissprot:APOL1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:APOL1_HUMAN
hmoment	swissprot:APOL1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:APOL1_HUMAN
iep	swissprot:APOL1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:APOL1_HUMAN
inforesidue	swissprot:APOL1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:APOL1_HUMAN
neXtProt	NX_O14791	http://www.nextprot.org/db/entry/NX_O14791
octanol	swissprot:APOL1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:APOL1_HUMAN
pepcoil	swissprot:APOL1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:APOL1_HUMAN
pepdigest	swissprot:APOL1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:APOL1_HUMAN
pepinfo	swissprot:APOL1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:APOL1_HUMAN
pepnet	swissprot:APOL1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:APOL1_HUMAN
pepstats	swissprot:APOL1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:APOL1_HUMAN
pepwheel	swissprot:APOL1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:APOL1_HUMAN
pepwindow	swissprot:APOL1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:APOL1_HUMAN
sigcleave	swissprot:APOL1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:APOL1_HUMAN
## Database	ID	URL or Descriptions
# AltName	PKDRE_HUMAN	PKD and REJ homolog
# BioGrid	115625	3
# Ensembl	ENST00000253255	ENSP00000253255; ENSG00000130943
# FUNCTION	PKDRE_HUMAN	May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acrosome reaction of the sperm. 
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005262	calcium channel activity; IBA:GO_Central.
# GO_function	GO:0005509	calcium ion binding; IEA:InterPro.
# GO_process	GO:0007340	acrosome reaction; TAS:ProtInc.
# GO_process	GO:0050982	detection of mechanical stimulus; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0008150	biological_process
# Gene3D	2.60.60.20	-; 1.
# Genevisible	Q9NTG1	HS
# HGNC	HGNC:9015	PKDREJ
# InterPro	IPR000203	GPS
# InterPro	IPR001024	PLAT/LH2_dom
# InterPro	IPR002859	PKD/REJ-like
# InterPro	IPR003915	PKD_2
# InterPro	IPR013122	PKD1_2_channel
# InterPro	IPR014010	REJ_dom
# MIM	604670	gene
# Organism	PKDRE_HUMAN	Homo sapiens (Human)
# PIR	T46355	T46355
# PRINTS	PR01433	POLYCYSTIN2
# PROSITE	PS50095	PLAT
# PROSITE	PS51111	REJ
# Pfam	PF01477	PLAT
# Pfam	PF02010	REJ
# Pfam	PF08016	PKD_channel
# Proteomes	UP000005640	Chromosome 22
# RecName	PKDRE_HUMAN	Polycystic kidney disease and receptor for egg jelly-related protein
# RefSeq	NP_006062	NM_006071.1
# SIMILARITY	Belongs to the polycystin family. {ECO	0000305}. 
# SIMILARITY	Contains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule	PRU00152}. 
# SIMILARITY	Contains 1 REJ domain. {ECO:0000255|PROSITE- ProRule	PRU00511}.
# SMART	SM00303	GPS
# SMART	SM00308	LH2
# SUBCELLULAR LOCATION	PKDRE_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUBUNIT	PKDRE_HUMAN	May form homomultimers or heteromultimers in combination with an as yet unidentified subunits. 
# SUPFAM	SSF49723	SSF49723
# TISSUE SPECIFICITY	PKDRE_HUMAN	Exclusively expressed in testis. 
# UCSC	uc003bhh	human
# eggNOG	ENOG410IQ5F	Eukaryota
# eggNOG	ENOG410ZBZ7	LUCA
BLAST	swissprot:PKDRE_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:PKDRE_HUMAN
BioCyc	ZFISH:ENSG00000130943-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000130943-MONOMER
COXPRESdb	10343	http://coxpresdb.jp/data/gene/10343.shtml
CleanEx	HS_PKDREJ	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_PKDREJ
DOI	10.1016/S0165-6147(00)01832-0	http://dx.doi.org/10.1016/S0165-6147(00)01832-0
DOI	10.1038/990031	http://dx.doi.org/10.1038/990031
DOI	10.1093/hmg/8.3.543	http://dx.doi.org/10.1093/hmg/8.3.543
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AF116458	http://www.ebi.ac.uk/ena/data/view/AF116458
EMBL	AL031034	http://www.ebi.ac.uk/ena/data/view/AL031034
EMBL	AL031034	http://www.ebi.ac.uk/ena/data/view/AL031034
EMBL	AL078611	http://www.ebi.ac.uk/ena/data/view/AL078611
EMBL	AL078611	http://www.ebi.ac.uk/ena/data/view/AL078611
EMBL	AL137288	http://www.ebi.ac.uk/ena/data/view/AL137288
EMBL	CH471138	http://www.ebi.ac.uk/ena/data/view/CH471138
EMBL	Z93024	http://www.ebi.ac.uk/ena/data/view/Z93024
EMBL	Z93024	http://www.ebi.ac.uk/ena/data/view/Z93024
Ensembl	ENST00000253255	http://www.ensembl.org/id/ENST00000253255
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_process	GO:0007340	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007340
GO_process	GO:0050982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050982
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	2.60.60.20	http://www.cathdb.info/version/latest/superfamily/2.60.60.20
GeneCards	PKDREJ	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=PKDREJ
GeneID	10343	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10343
GeneTree	ENSGT00700000104221	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00700000104221
HGNC	HGNC:9015	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:9015
HOVERGEN	HBG053603	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053603&db=HOVERGEN
HPA	HPA034587	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA034587
InParanoid	Q9NTG1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NTG1
IntAct	Q9NTG1	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NTG1*
InterPro	IPR000203	http://www.ebi.ac.uk/interpro/entry/IPR000203
InterPro	IPR001024	http://www.ebi.ac.uk/interpro/entry/IPR001024
InterPro	IPR002859	http://www.ebi.ac.uk/interpro/entry/IPR002859
InterPro	IPR003915	http://www.ebi.ac.uk/interpro/entry/IPR003915
InterPro	IPR013122	http://www.ebi.ac.uk/interpro/entry/IPR013122
InterPro	IPR014010	http://www.ebi.ac.uk/interpro/entry/IPR014010
Jabion	10343	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10343
KEGG_Gene	hsa:10343	http://www.genome.jp/dbget-bin/www_bget?hsa:10343
MIM	604670	http://www.ncbi.nlm.nih.gov/omim/604670
OMA	CRNCFYP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CRNCFYP
OrthoDB	EOG091G004D	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G004D
PRINTS	PR01433	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01433
PROSITE	PS50095	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50095
PROSITE	PS51111	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51111
PSORT	swissprot:PKDRE_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:PKDRE_HUMAN
PSORT-B	swissprot:PKDRE_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:PKDRE_HUMAN
PSORT2	swissprot:PKDRE_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:PKDRE_HUMAN
Pfam	PF01477	http://pfam.xfam.org/family/PF01477
Pfam	PF02010	http://pfam.xfam.org/family/PF02010
Pfam	PF08016	http://pfam.xfam.org/family/PF08016
PharmGKB	PA33347	http://www.pharmgkb.org/do/serve?objId=PA33347&objCls=Gene
Phobius	swissprot:PKDRE_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:PKDRE_HUMAN
PhylomeDB	Q9NTG1	http://phylomedb.org/?seqid=Q9NTG1
ProteinModelPortal	Q9NTG1	http://www.proteinmodelportal.org/query/uniprot/Q9NTG1
PubMed	10591208	http://www.ncbi.nlm.nih.gov/pubmed/10591208
PubMed	11698076	http://www.ncbi.nlm.nih.gov/pubmed/11698076
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	9949214	http://www.ncbi.nlm.nih.gov/pubmed/9949214
RefSeq	NP_006062	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006062
SMART	SM00303	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00303
SMART	SM00308	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00308
SMR	Q9NTG1	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9NTG1
STRING	9606.ENSP00000253255	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000253255&targetmode=cogs
SUPFAM	SSF49723	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49723
UCSC	uc003bhh	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003bhh&org=rat
UniGene	Hs.241383	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.241383
UniProtKB	PKDRE_HUMAN	http://www.uniprot.org/uniprot/PKDRE_HUMAN
UniProtKB-AC	Q9NTG1	http://www.uniprot.org/uniprot/Q9NTG1
charge	swissprot:PKDRE_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:PKDRE_HUMAN
eggNOG	ENOG410IQ5F	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IQ5F
eggNOG	ENOG410ZBZ7	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZBZ7
epestfind	swissprot:PKDRE_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:PKDRE_HUMAN
garnier	swissprot:PKDRE_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:PKDRE_HUMAN
helixturnhelix	swissprot:PKDRE_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:PKDRE_HUMAN
hmoment	swissprot:PKDRE_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:PKDRE_HUMAN
iep	swissprot:PKDRE_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:PKDRE_HUMAN
inforesidue	swissprot:PKDRE_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:PKDRE_HUMAN
neXtProt	NX_Q9NTG1	http://www.nextprot.org/db/entry/NX_Q9NTG1
octanol	swissprot:PKDRE_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:PKDRE_HUMAN
pepcoil	swissprot:PKDRE_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:PKDRE_HUMAN
pepdigest	swissprot:PKDRE_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:PKDRE_HUMAN
pepinfo	swissprot:PKDRE_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:PKDRE_HUMAN
pepnet	swissprot:PKDRE_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:PKDRE_HUMAN
pepstats	swissprot:PKDRE_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:PKDRE_HUMAN
pepwheel	swissprot:PKDRE_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:PKDRE_HUMAN
pepwindow	swissprot:PKDRE_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:PKDRE_HUMAN
sigcleave	swissprot:PKDRE_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:PKDRE_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	RHCE_HUMAN	Event=Alternative splicing; Named isoforms=14; Name=RHI; IsoId=P18577-1; Sequence=Displayed; Name=RHIV; Synonyms=1e; IsoId=P18577-2; Sequence=VSP_005703, VSP_005704; Name=RHVI; Synonyms=7c; IsoId=P18577-3; Sequence=VSP_005702, VSP_005705; Name=RHVIII; IsoId=P18577-4; Sequence=VSP_005701; Name=1c; IsoId=P18577-5; Sequence=VSP_005705; Name=1d; IsoId=P18577-6; Sequence=VSP_037514; Name=1h; IsoId=P18577-7; Sequence=VSP_037513; Name=2e; IsoId=P18577-8; Sequence=VSP_037510, VSP_037512; Name=4g; Synonyms=RhPI-Beta; IsoId=P18577-9; Sequence=VSP_037509; Name=7a; IsoId=P18577-10; Sequence=VSP_005702; Name=8a; IsoId=P18577-11; Sequence=VSP_037506, VSP_037511; Name=8e; IsoId=P18577-12; Sequence=VSP_037507, VSP_037508; Name=8h; IsoId=P18577-13; Sequence=VSP_037505; Name=RhPI-Alpha; IsoId=P18577-14; Sequence=VSP_038405, VSP_038406; 
# AltName	RHCE_HUMAN	CD240CE
# AltName	RHCE_HUMAN	Rh polypeptide 1
# AltName	RHCE_HUMAN	Rh30A
# AltName	RHCE_HUMAN	RhIXB
# AltName	RHCE_HUMAN	Rhesus C/E antigens
# CCDS	CCDS30634	-. [P18577-4]
# CCDS	CCDS30635	-. [P18577-1]
# CCDS	CCDS30636	-. [P18577-3]
# CCDS	CCDS30637	-. [P18577-2]
# CCDS	CCDS81283	-. [P18577-5]
# Ensembl	ENST00000294413	ENSP00000294413; ENSG00000188672
# ExpressionAtlas	P18577	baseline and differential
# FUNCTION	RHCE_HUMAN	May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane. 
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_function	GO:0008519	ammonium transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0015695	organic cation transport; IBA:GO_Central.
# GO_process	GO:0019740	nitrogen utilization; IBA:GO_Central.
# GO_process	GO:0072488	ammonium transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.10.3430.10	-; 1.
# Genevisible	P18577	HS
# HGNC	HGNC:10008	RHCE
# InterPro	IPR001905	Ammonium_transpt
# InterPro	IPR002229	RhesusRHD
# InterPro	IPR024041	NH4_transpt_AmtB-like_dom
# InterPro	IPR029020	Ammonium/urea_transptr
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko04090	 Cellular antigens
# MIM	111690	phenotype
# MIM	111700	gene+phenotype
# Organism	RHCE_HUMAN	Homo sapiens (Human)
# Orphanet	71275	Rh deficiency syndrome
# PANTHER	PTHR11730	PTHR11730
# PIR	A30405	A30405
# PIR	I54193	I54193
# PIR	PC2032	PC2032
# PIR	PC2033	PC2033
# PIR	S78478	S78478
# PIR	S78479	S78479
# PIR	S78480	S78480
# POLYMORPHISM	RHCE_HUMAN	RhCE and RhD are responsible for the RH blood group system. The molecular basis of the E=Rh3/e=Rh5 blood group antigens is a single variation in position 226; Pro-226 corresponds to Rh3 and Ala-226 to Rh5. The molecular basis of the C=Rh2/c=Rh4 blood group antigens is a single variation in position 102; Ser-103 corresponds to Rh2 and Pro-103 to Rh4. 
# PRINTS	PR00342	RHESUSRHD
# Pfam	PF00909	Ammonium_transp
# Proteomes	UP000005640	Chromosome 1
# RecName	RHCE_HUMAN	Blood group Rh(CE) polypeptide
# RefSeq	NP_001317359	NM_001330430.1
# RefSeq	NP_065231	NM_020485.4
# RefSeq	NP_619522	NM_138616.3. [P18577-4]
# RefSeq	NP_619523	NM_138617.3. [P18577-3]
# RefSeq	NP_619524	NM_138618.3
# SIMILARITY	Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	RHCE_HUMAN	Membrane; Multi-pass membrane protein. 
# SUPFAM	SSF111352	SSF111352
# TCDB	1.A.11.4	the ammonium transporter channel (amt) family
# TISSUE SPECIFICITY	Restricted to tissues or cell lines expressing erythroid characters. Isoform 4g and isoform RhPI-Alpha are expressed in immature erythroblasts but not in mature erythroblasts. {ECO:0000269|PubMed	8117271}. 
# UCSC	uc001bkf	human. [P18577-1]
# WEB RESOURCE	RHCE_HUMAN	Name=dbRBC/BGMUT; Note=Blood group antigen gene mutation database; URL="https //www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=rh";
# eggNOG	ENOG410XTF8	LUCA
# eggNOG	KOG3796	Eukaryota
BLAST	swissprot:RHCE_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:RHCE_HUMAN
COXPRESdb	6006	http://coxpresdb.jp/data/gene/6006.shtml
CleanEx	HS_RHCE	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_RHCE
DOI	10.1006/bbrc.1994.1161	http://dx.doi.org/10.1006/bbrc.1994.1161
DOI	10.1006/geno.1994.1014	http://dx.doi.org/10.1006/geno.1994.1014
DOI	10.1007/BF00209483	http://dx.doi.org/10.1007/BF00209483
DOI	10.1007/BF00222717	http://dx.doi.org/10.1007/BF00222717
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng0993-62	http://dx.doi.org/10.1038/ng0993-62
DOI	10.1042/bj2561043	http://dx.doi.org/10.1042/bj2561043
DOI	10.1042/bj2710821	http://dx.doi.org/10.1042/bj2710821
DOI	10.1046/j.1365-2141.2001.02803.x	http://dx.doi.org/10.1046/j.1365-2141.2001.02803.x
DOI	10.1046/j.1537-2995.2001.41111408.x	http://dx.doi.org/10.1046/j.1537-2995.2001.41111408.x
DOI	10.1073/pnas.87.16.6243	http://dx.doi.org/10.1073/pnas.87.16.6243
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1182/blood-2001-12-0153	http://dx.doi.org/10.1182/blood-2001-12-0153
DOI	10.1182/blood-2002-01-0229	http://dx.doi.org/10.1182/blood-2002-01-0229
EMBL	AB018644	http://www.ebi.ac.uk/ena/data/view/AB018644
EMBL	AB018645	http://www.ebi.ac.uk/ena/data/view/AB018645
EMBL	AB030388	http://www.ebi.ac.uk/ena/data/view/AB030388
EMBL	AB049753	http://www.ebi.ac.uk/ena/data/view/AB049753
EMBL	AF510065	http://www.ebi.ac.uk/ena/data/view/AF510065
EMBL	AF510066	http://www.ebi.ac.uk/ena/data/view/AF510066
EMBL	AF510067	http://www.ebi.ac.uk/ena/data/view/AF510067
EMBL	AF510068	http://www.ebi.ac.uk/ena/data/view/AF510068
EMBL	AL031284	http://www.ebi.ac.uk/ena/data/view/AL031284
EMBL	AL031284	http://www.ebi.ac.uk/ena/data/view/AL031284
EMBL	AL928711	http://www.ebi.ac.uk/ena/data/view/AL928711
EMBL	AL928711	http://www.ebi.ac.uk/ena/data/view/AL928711
EMBL	AM398146	http://www.ebi.ac.uk/ena/data/view/AM398146
EMBL	AY603478	http://www.ebi.ac.uk/ena/data/view/AY603478
EMBL	BC075081	http://www.ebi.ac.uk/ena/data/view/BC075081
EMBL	BC139905	http://www.ebi.ac.uk/ena/data/view/BC139905
EMBL	BN000065	http://www.ebi.ac.uk/ena/data/view/BN000065
EMBL	DQ178642	http://www.ebi.ac.uk/ena/data/view/DQ178642
EMBL	DQ266353	http://www.ebi.ac.uk/ena/data/view/DQ266353
EMBL	DQ266400	http://www.ebi.ac.uk/ena/data/view/DQ266400
EMBL	DQ322275	http://www.ebi.ac.uk/ena/data/view/DQ322275
EMBL	FJ486155	http://www.ebi.ac.uk/ena/data/view/FJ486155
EMBL	FJ486156	http://www.ebi.ac.uk/ena/data/view/FJ486156
EMBL	FJ486157	http://www.ebi.ac.uk/ena/data/view/FJ486157
EMBL	FJ486158	http://www.ebi.ac.uk/ena/data/view/FJ486158
EMBL	FJ486159	http://www.ebi.ac.uk/ena/data/view/FJ486159
EMBL	FJ486160	http://www.ebi.ac.uk/ena/data/view/FJ486160
EMBL	FJ486161	http://www.ebi.ac.uk/ena/data/view/FJ486161
EMBL	FJ486162	http://www.ebi.ac.uk/ena/data/view/FJ486162
EMBL	FJ486163	http://www.ebi.ac.uk/ena/data/view/FJ486163
EMBL	FJ486164	http://www.ebi.ac.uk/ena/data/view/FJ486164
EMBL	FJ486165	http://www.ebi.ac.uk/ena/data/view/FJ486165
EMBL	M34015	http://www.ebi.ac.uk/ena/data/view/M34015
EMBL	S57967	http://www.ebi.ac.uk/ena/data/view/S57967
EMBL	S70456	http://www.ebi.ac.uk/ena/data/view/S70456
EMBL	X54534	http://www.ebi.ac.uk/ena/data/view/X54534
EMBL	X63095	http://www.ebi.ac.uk/ena/data/view/X63095
EMBL	X63096	http://www.ebi.ac.uk/ena/data/view/X63096
EMBL	X63098	http://www.ebi.ac.uk/ena/data/view/X63098
Ensembl	ENST00000294413	http://www.ensembl.org/id/ENST00000294413
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0008519	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008519
GO_process	GO:0015695	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015695
GO_process	GO:0019740	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019740
GO_process	GO:0072488	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072488
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.10.3430.10	http://www.cathdb.info/version/latest/superfamily/1.10.3430.10
GeneCards	RHCE	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=RHCE
GeneID	6006	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6006
H-InvDB	HIX0023511	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0023511
HGNC	HGNC:10008	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10008
HOVERGEN	HBG004374	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004374&db=HOVERGEN
InParanoid	P18577	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P18577
InterPro	IPR001905	http://www.ebi.ac.uk/interpro/entry/IPR001905
InterPro	IPR002229	http://www.ebi.ac.uk/interpro/entry/IPR002229
InterPro	IPR024041	http://www.ebi.ac.uk/interpro/entry/IPR024041
InterPro	IPR029020	http://www.ebi.ac.uk/interpro/entry/IPR029020
Jabion	6006	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6006
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko04090	http://www.genome.jp/dbget-bin/www_bget?ko04090
KEGG_Gene	hsa:6006	http://www.genome.jp/dbget-bin/www_bget?hsa:6006
KEGG_Orthology	KO:K06579	http://www.genome.jp/dbget-bin/www_bget?KO:K06579
MIM	111690	http://www.ncbi.nlm.nih.gov/omim/111690
MIM	111700	http://www.ncbi.nlm.nih.gov/omim/111700
Orphanet	71275	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=71275
OrthoDB	EOG091G06KX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G06KX
PANTHER	PTHR11730	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11730
PRINTS	PR00342	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00342
PSORT	swissprot:RHCE_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:RHCE_HUMAN
PSORT-B	swissprot:RHCE_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:RHCE_HUMAN
PSORT2	swissprot:RHCE_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:RHCE_HUMAN
Pfam	PF00909	http://pfam.xfam.org/family/PF00909
PharmGKB	PA34386	http://www.pharmgkb.org/do/serve?objId=PA34386&objCls=Gene
Phobius	swissprot:RHCE_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:RHCE_HUMAN
PhylomeDB	P18577	http://phylomedb.org/?seqid=P18577
ProteinModelPortal	P18577	http://www.proteinmodelportal.org/query/uniprot/P18577
PubMed	11380456	http://www.ncbi.nlm.nih.gov/pubmed/11380456
PubMed	11724987	http://www.ncbi.nlm.nih.gov/pubmed/11724987
PubMed	11902138	http://www.ncbi.nlm.nih.gov/pubmed/11902138
PubMed	12393640	http://www.ncbi.nlm.nih.gov/pubmed/12393640
PubMed	1379850	http://www.ncbi.nlm.nih.gov/pubmed/1379850
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	1696722	http://www.ncbi.nlm.nih.gov/pubmed/1696722
PubMed	1898705	http://www.ncbi.nlm.nih.gov/pubmed/1898705
PubMed	2123099	http://www.ncbi.nlm.nih.gov/pubmed/2123099
PubMed	3135863	http://www.ncbi.nlm.nih.gov/pubmed/3135863
PubMed	3146980	http://www.ncbi.nlm.nih.gov/pubmed/3146980
PubMed	7789951	http://www.ncbi.nlm.nih.gov/pubmed/7789951
PubMed	7916743	http://www.ncbi.nlm.nih.gov/pubmed/7916743
PubMed	8117271	http://www.ncbi.nlm.nih.gov/pubmed/8117271
PubMed	8188244	http://www.ncbi.nlm.nih.gov/pubmed/8188244
PubMed	8220426	http://www.ncbi.nlm.nih.gov/pubmed/8220426
RefSeq	NP_001317359	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001317359
RefSeq	NP_065231	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_065231
RefSeq	NP_619522	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_619522
RefSeq	NP_619523	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_619523
RefSeq	NP_619524	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_619524
STRING	9606.ENSP00000294413	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000294413&targetmode=cogs
SUPFAM	SSF111352	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF111352
TCDB	1.A.11.4	http://www.tcdb.org/search/result.php?tc=1.A.11.4
UCSC	uc001bkf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001bkf&org=rat
UniGene	Hs.449968	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.449968
UniGene	Hs.523054	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.523054
UniProtKB	RHCE_HUMAN	http://www.uniprot.org/uniprot/RHCE_HUMAN
UniProtKB-AC	P18577	http://www.uniprot.org/uniprot/P18577
charge	swissprot:RHCE_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:RHCE_HUMAN
eggNOG	ENOG410XTF8	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XTF8
eggNOG	KOG3796	http://eggnogapi.embl.de/nog_data/html/tree/KOG3796
epestfind	swissprot:RHCE_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:RHCE_HUMAN
garnier	swissprot:RHCE_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:RHCE_HUMAN
helixturnhelix	swissprot:RHCE_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:RHCE_HUMAN
hmoment	swissprot:RHCE_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:RHCE_HUMAN
iep	swissprot:RHCE_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:RHCE_HUMAN
inforesidue	swissprot:RHCE_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:RHCE_HUMAN
neXtProt	NX_P18577	http://www.nextprot.org/db/entry/NX_P18577
octanol	swissprot:RHCE_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:RHCE_HUMAN
pepcoil	swissprot:RHCE_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:RHCE_HUMAN
pepdigest	swissprot:RHCE_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:RHCE_HUMAN
pepinfo	swissprot:RHCE_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:RHCE_HUMAN
pepnet	swissprot:RHCE_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:RHCE_HUMAN
pepstats	swissprot:RHCE_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:RHCE_HUMAN
pepwheel	swissprot:RHCE_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:RHCE_HUMAN
pepwindow	swissprot:RHCE_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:RHCE_HUMAN
sigcleave	swissprot:RHCE_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:RHCE_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNK7_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=A; IsoId=Q9Y2U2-1; Sequence=Displayed; Name=B; IsoId=Q9Y2U2-2; Sequence=VSP_006693, VSP_006694; Name=C; IsoId=Q9Y2U2-3; Sequence=VSP_006695, VSP_006696; 
# CCDS	CCDS31608	-. [Q9Y2U2-1]
# CCDS	CCDS41673	-. [Q9Y2U2-3]
# CCDS	CCDS8106	-. [Q9Y2U2-2]
# Ensembl	ENST00000340313	ENSP00000344820; ENSG00000173338. [Q9Y2U2-1]
# Ensembl	ENST00000342202	ENSP00000343923; ENSG00000173338. [Q9Y2U2-2]
# Ensembl	ENST00000394216	ENSP00000377764; ENSG00000173338. [Q9Y2U2-3]
# Ensembl	ENST00000394217	ENSP00000377765; ENSG00000173338. [Q9Y2U2-2]
# ExpressionAtlas	Q9Y2U2	baseline and differential
# FUNCTION	KCNK7_HUMAN	Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0005244	voltage-gated ion channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0005267	potassium channel activity; TAS:Reactome.
# GO_function	GO:0022841	potassium ion leak channel activity; IBA:GO_Central.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0030322	stabilization of membrane potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q9Y2U2	HS
# HGNC	HGNC:6282	KCNK7
# InterPro	IPR003092	2pore_dom_K_chnl_TASK
# InterPro	IPR003280	2pore_dom_K_chnl
# InterPro	IPR005408	2pore_dom_K_chnl_TWIK
# InterPro	IPR013099	K_chnl_dom
# KEGG_Brite	ko04040	Ion channels
# MIM	603940	gene
# Organism	KCNK7_HUMAN	Homo sapiens (Human)
# PIRSF	PIRSF038061	K_channel_subfamily_K_type
# PRINTS	PR01333	2POREKCHANEL
# PRINTS	PR01586	TWIKCHANNEL
# Pfam	PF07885	Ion_trans_2; 2
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-1299308	Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)
# Reactome	R-HSA-5576886	Phase 4 - resting membrane potential
# RecName	KCNK7_HUMAN	Potassium channel subfamily K member 7
# RefSeq	NP_005705	NM_005714.1. [Q9Y2U2-3]
# RefSeq	NP_203133	NM_033347.1. [Q9Y2U2-1]
# RefSeq	NP_203134	NM_033348.1. [Q9Y2U2-2]
# RefSeq	NP_258416	NM_033455.1. [Q9Y2U2-2]
# SIMILARITY	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCNK7_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUBUNIT	Homodimer. {ECO	0000305}. 
# UCSC	uc001oeq	human. [Q9Y2U2-1]
# eggNOG	COG1226	LUCA
# eggNOG	KOG1418	Eukaryota
BLAST	swissprot:KCNK7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNK7_HUMAN
BioCyc	ZFISH:ENSG00000173338-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000173338-MONOMER
COXPRESdb	10089	http://coxpresdb.jp/data/gene/10089.shtml
CleanEx	HS_KCNK7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNK7
DOI	10.1074/jbc.274.17.11751	http://dx.doi.org/10.1074/jbc.274.17.11751
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF110522	http://www.ebi.ac.uk/ena/data/view/AF110522
EMBL	AF110523	http://www.ebi.ac.uk/ena/data/view/AF110523
EMBL	AF110524	http://www.ebi.ac.uk/ena/data/view/AF110524
EMBL	BC103809	http://www.ebi.ac.uk/ena/data/view/BC103809
EMBL	CH471076	http://www.ebi.ac.uk/ena/data/view/CH471076
Ensembl	ENST00000340313	http://www.ensembl.org/id/ENST00000340313
Ensembl	ENST00000342202	http://www.ensembl.org/id/ENST00000342202
Ensembl	ENST00000394216	http://www.ensembl.org/id/ENST00000394216
Ensembl	ENST00000394217	http://www.ensembl.org/id/ENST00000394217
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005244
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_function	GO:0022841	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022841
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0030322	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030322
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	KCNK7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNK7
GeneID	10089	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10089
GeneTree	ENSGT00760000118858	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118858
HGNC	HGNC:6282	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6282
HOGENOM	HOG000286014	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000286014&db=HOGENOM6
HOVERGEN	HBG052237	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052237&db=HOVERGEN
InParanoid	Q9Y2U2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y2U2
InterPro	IPR003092	http://www.ebi.ac.uk/interpro/entry/IPR003092
InterPro	IPR003280	http://www.ebi.ac.uk/interpro/entry/IPR003280
InterPro	IPR005408	http://www.ebi.ac.uk/interpro/entry/IPR005408
InterPro	IPR013099	http://www.ebi.ac.uk/interpro/entry/IPR013099
Jabion	10089	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10089
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:10089	http://www.genome.jp/dbget-bin/www_bget?hsa:10089
KEGG_Orthology	KO:K04918	http://www.genome.jp/dbget-bin/www_bget?KO:K04918
MIM	603940	http://www.ncbi.nlm.nih.gov/omim/603940
OMA	AWVAVHW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AWVAVHW
OrthoDB	EOG091G0DIX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0DIX
PRINTS	PR01333	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01333
PRINTS	PR01586	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01586
PSORT	swissprot:KCNK7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNK7_HUMAN
PSORT-B	swissprot:KCNK7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNK7_HUMAN
PSORT2	swissprot:KCNK7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNK7_HUMAN
Pfam	PF07885	http://pfam.xfam.org/family/PF07885
PharmGKB	PA30064	http://www.pharmgkb.org/do/serve?objId=PA30064&objCls=Gene
Phobius	swissprot:KCNK7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNK7_HUMAN
PhylomeDB	Q9Y2U2	http://phylomedb.org/?seqid=Q9Y2U2
ProteinModelPortal	Q9Y2U2	http://www.proteinmodelportal.org/query/uniprot/Q9Y2U2
PubMed	10206991	http://www.ncbi.nlm.nih.gov/pubmed/10206991
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-1299308	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1299308
Reactome	R-HSA-5576886	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576886
RefSeq	NP_005705	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005705
RefSeq	NP_203133	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_203133
RefSeq	NP_203134	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_203134
RefSeq	NP_258416	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_258416
SMR	Q9Y2U2	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9Y2U2
STRING	9606.ENSP00000344820	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000344820&targetmode=cogs
UCSC	uc001oeq	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001oeq&org=rat
UniGene	Hs.175218	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.175218
UniProtKB	KCNK7_HUMAN	http://www.uniprot.org/uniprot/KCNK7_HUMAN
UniProtKB-AC	Q9Y2U2	http://www.uniprot.org/uniprot/Q9Y2U2
charge	swissprot:KCNK7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNK7_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG1418	http://eggnogapi.embl.de/nog_data/html/tree/KOG1418
epestfind	swissprot:KCNK7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNK7_HUMAN
garnier	swissprot:KCNK7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNK7_HUMAN
helixturnhelix	swissprot:KCNK7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNK7_HUMAN
hmoment	swissprot:KCNK7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNK7_HUMAN
iep	swissprot:KCNK7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNK7_HUMAN
inforesidue	swissprot:KCNK7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNK7_HUMAN
neXtProt	NX_Q9Y2U2	http://www.nextprot.org/db/entry/NX_Q9Y2U2
octanol	swissprot:KCNK7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNK7_HUMAN
pepcoil	swissprot:KCNK7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNK7_HUMAN
pepdigest	swissprot:KCNK7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNK7_HUMAN
pepinfo	swissprot:KCNK7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNK7_HUMAN
pepnet	swissprot:KCNK7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNK7_HUMAN
pepstats	swissprot:KCNK7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNK7_HUMAN
pepwheel	swissprot:KCNK7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNK7_HUMAN
pepwindow	swissprot:KCNK7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNK7_HUMAN
sigcleave	swissprot:KCNK7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNK7_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ACHA7_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P36544-1; Sequence=Displayed; Name=2; IsoId=P36544-2; Sequence=VSP_043019; Note=No experimental confirmation available.; Name=3; IsoId=P36544-3; Sequence=VSP_058107, VSP_058108; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 
# BioGrid	107561	3
# CCDS	CCDS10027	-. [P36544-1]
# CCDS	CCDS53924	-. [P36544-2]
# ChiTaRS	CHRNA7	human
# DrugBank	DB00184	Nicotine
# DrugBank	DB00237	Butabarbital
# DrugBank	DB00241	Butalbital
# DrugBank	DB00306	Talbutal
# DrugBank	DB00312	Pentobarbital
# DrugBank	DB00418	Secobarbital
# DrugBank	DB00514	Dextromethorphan
# DrugBank	DB00599	Thiopental
# DrugBank	DB00674	Galantamine
# DrugBank	DB00794	Primidone
# DrugBank	DB00849	Methylphenobarbital
# DrugBank	DB00898	Ethanol
# DrugBank	DB01174	Phenobarbital
# DrugBank	DB01273	Varenicline
# DrugBank	DB01351	Amobarbital
# DrugBank	DB01352	Aprobarbital
# DrugBank	DB01353	Butethal
# DrugBank	DB01354	Heptabarbital
# DrugBank	DB01355	Hexobarbital
# DrugBank	DB09028	Cytisine
# Ensembl	ENST00000306901	ENSP00000303727; ENSG00000175344. [P36544-1]
# Ensembl	ENST00000437966	ENSP00000399087; ENSG00000175344. [P36544-3]
# Ensembl	ENST00000454250	ENSP00000407546; ENSG00000175344. [P36544-2]
# ExpressionAtlas	P36544	baseline and differential
# FUNCTION	ACHA7_HUMAN	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. 
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005892	acetylcholine-gated channel complex; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0001540	beta-amyloid binding; IPI:UniProtKB.
# GO_function	GO:0004889	acetylcholine-activated cation-selective channel activity; IDA:UniProtKB.
# GO_function	GO:0015276	ligand-gated ion channel activity; TAS:Reactome.
# GO_function	GO:0015464	acetylcholine receptor activity; IDA:UniProtKB.
# GO_function	GO:0015643	toxic substance binding; IDA:UniProtKB.
# GO_function	GO:0017081	chloride channel regulator activity; IDA:UniProtKB.
# GO_function	GO:0022848	acetylcholine-gated cation channel activity; IDA:ParkinsonsUK-UCL.
# GO_function	GO:0042166	acetylcholine binding; IDA:UniProtKB.
# GO_function	GO:0042803	protein homodimerization activity; IDA:UniProtKB.
# GO_process	GO:0000187	activation of MAPK activity; IDA:UniProtKB.
# GO_process	GO:0001666	response to hypoxia; IDA:UniProtKB.
# GO_process	GO:0006811	ion transport; NAS:UniProtKB.
# GO_process	GO:0006816	calcium ion transport; IDA:UniProtKB.
# GO_process	GO:0006874	cellular calcium ion homeostasis; IMP:UniProtKB.
# GO_process	GO:0007165	signal transduction; IDA:UniProtKB.
# GO_process	GO:0007271	synaptic transmission, cholinergic; IBA:GO_Central.
# GO_process	GO:0007613	memory; NAS:UniProtKB.
# GO_process	GO:0008284	positive regulation of cell proliferation; IMP:UniProtKB.
# GO_process	GO:0032720	negative regulation of tumor necrosis factor production; IMP:UniProtKB.
# GO_process	GO:0034220	ion transmembrane transport; IDA:ParkinsonsUK-UCL.
# GO_process	GO:0035094	response to nicotine; IDA:UniProtKB.
# GO_process	GO:0045766	positive regulation of angiogenesis; IMP:UniProtKB.
# GO_process	GO:0050890	cognition; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.370	-; 2.
# Gene3D	2.70.170.10	-; 1.
# Genevisible	P36544	HS
# HGNC	HGNC:1960	CHRNA7
# IntAct	P36544	2
# InterPro	IPR002394	Nicotinic_acetylcholine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# InterPro	IPR027361	Acetylcholine_rcpt_TM
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04725	Cholinergic synapse
# KEGG_Pathway	ko05033	Nicotine addiction
# KEGG_Pathway	ko05204	Chemical carcinogenesis
# MASS SPECTROMETRY	Mass=54157.68; Method=MALDI; Range=23-502; Evidence={ECO:0000269|PubMed	11840567}; 
# MIM	118511	gene
# Organism	ACHA7_HUMAN	Homo sapiens (Human)
# Orphanet	199318	15q13.3 microdeletion syndrome
# PANTHER	PTHR18945	PTHR18945; 3
# PDB	2MAW	NMR; -; A=228-326, A=467-495
# PDB	5AFH	X-ray; 2.40 A; A/B/C/D/E=23-227
# PDB	5AFJ	X-ray; 2.20 A; A/B/C/D/E=23-227
# PDB	5AFK	X-ray; 2.38 A; A/B/C/D/E=23-227
# PDB	5AFL	X-ray; 2.38 A; A/B/C/D/E=23-227
# PDB	5AFM	X-ray; 2.85 A; A/B/C/D/E=23-38, A/B/C/D/E=52-71, A/B/C/D/E=77-98, A/C/D/E=23-192, A/C/D/E=96-227, B=131-141, B=164-168, B=178-192
# PDB	5AFN	X-ray; 2.15 A; A/B/C/D/E=23-227
# PIR	G02259	G02259
# PIR	I37185	ACHUA7
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00254	NICOTINICR
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 15
# Reactome	R-HSA-629594	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
# RecName	ACHA7_HUMAN	Neuronal acetylcholine receptor subunit alpha-7
# RefSeq	NP_000737	NM_000746.5. [P36544-1]
# RefSeq	NP_001177384	NM_001190455.2. [P36544-2]
# RefSeq	NP_683709	NM_148911.1
# RefSeq	XP_005254807	XM_005254750.2
# RefSeq	XP_016877373	XM_017021884.1
# SEQUENCE CAUTION	Sequence=AAH37571.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 7/CHRNA7 sub-subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	ACHA7_HUMAN	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	ACHA7_HUMAN	Homopentamer. Interacts with RIC3; which is required for proper folding and assembly. {ECO 0000269|PubMed 15504725, ECO 0000269|PubMed 16120769}. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TCDB	1.A.9.1	the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family
# TIGRFAMs	TIGR00860	LIC
# UCSC	uc001zft	human. [P36544-1]
# eggNOG	ENOG410XQGR	LUCA
# eggNOG	KOG3645	Eukaryota
BLAST	swissprot:ACHA7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ACHA7_HUMAN
BioCyc	ZFISH:ENSG00000175344-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000175344-MONOMER
COXPRESdb	1139	http://coxpresdb.jp/data/gene/1139.shtml
COXPRESdb	89832	http://coxpresdb.jp/data/gene/89832.shtml
CleanEx	HS_CHRNA7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CHRNA7
DOI	10.1002/1615-9861(200202)2:2<212::AID-PROT212>3.0.CO	http://dx.doi.org/10.1002/1615-9861(200202)2:2<212::AID-PROT212>3.0.CO
DOI	10.1006/geno.1994.1075	http://dx.doi.org/10.1006/geno.1994.1075
DOI	10.1006/geno.2002.6694	http://dx.doi.org/10.1006/geno.2002.6694
DOI	10.1007/BF02736842	http://dx.doi.org/10.1007/BF02736842
DOI	10.1016/S0014-5793(96)01383-X	http://dx.doi.org/10.1016/S0014-5793(96)01383-X
DOI	10.1038/nature04601	http://dx.doi.org/10.1038/nature04601
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M410039200	http://dx.doi.org/10.1074/jbc.M410039200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1124/mol.105.017459	http://dx.doi.org/10.1124/mol.105.017459
DrugBank	DB00184	http://www.drugbank.ca/drugs/DB00184
DrugBank	DB00237	http://www.drugbank.ca/drugs/DB00237
DrugBank	DB00241	http://www.drugbank.ca/drugs/DB00241
DrugBank	DB00306	http://www.drugbank.ca/drugs/DB00306
DrugBank	DB00312	http://www.drugbank.ca/drugs/DB00312
DrugBank	DB00418	http://www.drugbank.ca/drugs/DB00418
DrugBank	DB00514	http://www.drugbank.ca/drugs/DB00514
DrugBank	DB00599	http://www.drugbank.ca/drugs/DB00599
DrugBank	DB00674	http://www.drugbank.ca/drugs/DB00674
DrugBank	DB00794	http://www.drugbank.ca/drugs/DB00794
DrugBank	DB00849	http://www.drugbank.ca/drugs/DB00849
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01174	http://www.drugbank.ca/drugs/DB01174
DrugBank	DB01273	http://www.drugbank.ca/drugs/DB01273
DrugBank	DB01351	http://www.drugbank.ca/drugs/DB01351
DrugBank	DB01352	http://www.drugbank.ca/drugs/DB01352
DrugBank	DB01353	http://www.drugbank.ca/drugs/DB01353
DrugBank	DB01354	http://www.drugbank.ca/drugs/DB01354
DrugBank	DB01355	http://www.drugbank.ca/drugs/DB01355
DrugBank	DB09028	http://www.drugbank.ca/drugs/DB09028
EMBL	AC004460	http://www.ebi.ac.uk/ena/data/view/AC004460
EMBL	AC009562	http://www.ebi.ac.uk/ena/data/view/AC009562
EMBL	AC012236	http://www.ebi.ac.uk/ena/data/view/AC012236
EMBL	AC021316	http://www.ebi.ac.uk/ena/data/view/AC021316
EMBL	AC026150	http://www.ebi.ac.uk/ena/data/view/AC026150
EMBL	AC026951	http://www.ebi.ac.uk/ena/data/view/AC026951
EMBL	AC058803	http://www.ebi.ac.uk/ena/data/view/AC058803
EMBL	AC068448	http://www.ebi.ac.uk/ena/data/view/AC068448
EMBL	AC079969	http://www.ebi.ac.uk/ena/data/view/AC079969
EMBL	AC087481	http://www.ebi.ac.uk/ena/data/view/AC087481
EMBL	AC090829	http://www.ebi.ac.uk/ena/data/view/AC090829
EMBL	AC091057	http://www.ebi.ac.uk/ena/data/view/AC091057
EMBL	AC104266	http://www.ebi.ac.uk/ena/data/view/AC104266
EMBL	AC104759	http://www.ebi.ac.uk/ena/data/view/AC104759
EMBL	AF332758	http://www.ebi.ac.uk/ena/data/view/AF332758
EMBL	AF385585	http://www.ebi.ac.uk/ena/data/view/AF385585
EMBL	AK292069	http://www.ebi.ac.uk/ena/data/view/AK292069
EMBL	AK294229	http://www.ebi.ac.uk/ena/data/view/AK294229
EMBL	BC037571	http://www.ebi.ac.uk/ena/data/view/BC037571
EMBL	BC101345	http://www.ebi.ac.uk/ena/data/view/BC101345
EMBL	L25827	http://www.ebi.ac.uk/ena/data/view/L25827
EMBL	U40583	http://www.ebi.ac.uk/ena/data/view/U40583
EMBL	U62436	http://www.ebi.ac.uk/ena/data/view/U62436
EMBL	X70297	http://www.ebi.ac.uk/ena/data/view/X70297
EMBL	Y08420	http://www.ebi.ac.uk/ena/data/view/Y08420
EMBL	Z23141	http://www.ebi.ac.uk/ena/data/view/Z23141
Ensembl	ENST00000306901	http://www.ensembl.org/id/ENST00000306901
Ensembl	ENST00000437966	http://www.ensembl.org/id/ENST00000437966
Ensembl	ENST00000454250	http://www.ensembl.org/id/ENST00000454250
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005892	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005892
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0001540	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001540
GO_function	GO:0004889	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004889
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_function	GO:0015464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015464
GO_function	GO:0015643	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015643
GO_function	GO:0017081	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017081
GO_function	GO:0022848	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022848
GO_function	GO:0042166	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042166
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_process	GO:0000187	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000187
GO_process	GO:0001666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001666
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0006874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007271
GO_process	GO:0007613	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007613
GO_process	GO:0008284	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008284
GO_process	GO:0032720	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032720
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0035094	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035094
GO_process	GO:0045766	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045766
GO_process	GO:0050890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050890
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.370	http://www.cathdb.info/version/latest/superfamily/1.20.120.370
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	CHRNA7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CHRNA7
GeneID	1139	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1139
GeneID	89832	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=89832
GeneTree	ENSGT00790000122957	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00790000122957
HGNC	HGNC:1960	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1960
HOGENOM	HOG000006756	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006756&db=HOGENOM6
HOVERGEN	HBG003756	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003756&db=HOVERGEN
HPA	CAB033624	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB033624
HPA	HPA029422	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA029422
InParanoid	P36544	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36544
IntAct	P36544	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36544*
InterPro	IPR002394	http://www.ebi.ac.uk/interpro/entry/IPR002394
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
InterPro	IPR027361	http://www.ebi.ac.uk/interpro/entry/IPR027361
Jabion	1139	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1139
Jabion	89832	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=89832
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:1139	http://www.genome.jp/dbget-bin/www_bget?hsa:1139
KEGG_Orthology	KO:K04809	http://www.genome.jp/dbget-bin/www_bget?KO:K04809
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04725	http://www.genome.jp/kegg-bin/show_pathway?ko04725
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
KEGG_Pathway	ko05204	http://www.genome.jp/kegg-bin/show_pathway?ko05204
MIM	118511	http://www.ncbi.nlm.nih.gov/omim/118511
OMA	FPQPHSL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FPQPHSL
Orphanet	199318	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=199318
OrthoDB	EOG091G0R20	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0R20
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PDB	2MAW	http://www.ebi.ac.uk/pdbe-srv/view/entry/2MAW
PDB	5AFH	http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFH
PDB	5AFJ	http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFJ
PDB	5AFK	http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFK
PDB	5AFL	http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFL
PDB	5AFM	http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFM
PDB	5AFN	http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFN
PDBsum	2MAW	http://www.ebi.ac.uk/pdbsum/2MAW
PDBsum	5AFH	http://www.ebi.ac.uk/pdbsum/5AFH
PDBsum	5AFJ	http://www.ebi.ac.uk/pdbsum/5AFJ
PDBsum	5AFK	http://www.ebi.ac.uk/pdbsum/5AFK
PDBsum	5AFL	http://www.ebi.ac.uk/pdbsum/5AFL
PDBsum	5AFM	http://www.ebi.ac.uk/pdbsum/5AFM
PDBsum	5AFN	http://www.ebi.ac.uk/pdbsum/5AFN
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00254	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00254
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:ACHA7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ACHA7_HUMAN
PSORT-B	swissprot:ACHA7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ACHA7_HUMAN
PSORT2	swissprot:ACHA7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ACHA7_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA114	http://www.pharmgkb.org/do/serve?objId=PA114&objCls=Gene
PharmGKB	PA26483	http://www.pharmgkb.org/do/serve?objId=PA26483&objCls=Gene
Phobius	swissprot:ACHA7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ACHA7_HUMAN
PhylomeDB	P36544	http://phylomedb.org/?seqid=P36544
ProteinModelPortal	P36544	http://www.proteinmodelportal.org/query/uniprot/P36544
PubMed	11829490	http://www.ncbi.nlm.nih.gov/pubmed/11829490
PubMed	11840567	http://www.ncbi.nlm.nih.gov/pubmed/11840567
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15504725	http://www.ncbi.nlm.nih.gov/pubmed/15504725
PubMed	16120769	http://www.ncbi.nlm.nih.gov/pubmed/16120769
PubMed	16572171	http://www.ncbi.nlm.nih.gov/pubmed/16572171
PubMed	8145738	http://www.ncbi.nlm.nih.gov/pubmed/8145738
PubMed	8188270	http://www.ncbi.nlm.nih.gov/pubmed/8188270
PubMed	8906617	http://www.ncbi.nlm.nih.gov/pubmed/8906617
PubMed	9009220	http://www.ncbi.nlm.nih.gov/pubmed/9009220
Reactome	R-HSA-629594	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-629594
RefSeq	NP_000737	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000737
RefSeq	NP_001177384	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001177384
RefSeq	NP_683709	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_683709
RefSeq	XP_005254807	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005254807
RefSeq	XP_016877373	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016877373
SMR	P36544	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P36544
STRING	9606.ENSP00000299847	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000299847&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TCDB	1.A.9.1	http://www.tcdb.org/search/result.php?tc=1.A.9.1
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc001zft	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001zft&org=rat
UniGene	Hs.510853	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.510853
UniGene	Hs.511772	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.511772
UniGene	Hs.713151	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.713151
UniProtKB	ACHA7_HUMAN	http://www.uniprot.org/uniprot/ACHA7_HUMAN
UniProtKB-AC	P36544	http://www.uniprot.org/uniprot/P36544
charge	swissprot:ACHA7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ACHA7_HUMAN
eggNOG	ENOG410XQGR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQGR
eggNOG	KOG3645	http://eggnogapi.embl.de/nog_data/html/tree/KOG3645
epestfind	swissprot:ACHA7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ACHA7_HUMAN
garnier	swissprot:ACHA7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ACHA7_HUMAN
helixturnhelix	swissprot:ACHA7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACHA7_HUMAN
hmoment	swissprot:ACHA7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ACHA7_HUMAN
iep	swissprot:ACHA7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ACHA7_HUMAN
inforesidue	swissprot:ACHA7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ACHA7_HUMAN
neXtProt	NX_P36544	http://www.nextprot.org/db/entry/NX_P36544
octanol	swissprot:ACHA7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ACHA7_HUMAN
pepcoil	swissprot:ACHA7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ACHA7_HUMAN
pepdigest	swissprot:ACHA7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ACHA7_HUMAN
pepinfo	swissprot:ACHA7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ACHA7_HUMAN
pepnet	swissprot:ACHA7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ACHA7_HUMAN
pepstats	swissprot:ACHA7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ACHA7_HUMAN
pepwheel	swissprot:ACHA7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ACHA7_HUMAN
pepwindow	swissprot:ACHA7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ACHA7_HUMAN
sigcleave	swissprot:ACHA7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ACHA7_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	NIPA1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7RTP0-1; Sequence=Displayed; Name=2; IsoId=Q7RTP0-2; Sequence=VSP_017189; 
# AltName	NIPA1_HUMAN	Non-imprinted in Prader-Willi/Angelman syndrome region protein 1
# AltName	NIPA1_HUMAN	Spastic paraplegia 6 protein
# CCDS	CCDS73691	-. [Q7RTP0-1]
# CCDS	CCDS73692	-. [Q7RTP0-2]
# ChiTaRS	NIPA1	human
# DISEASE	NIPA1_HUMAN	Spastic paraplegia 6, autosomal dominant (SPG6) [MIM 600363]  A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. {ECO 0000269|PubMed 14508710, ECO 0000269|PubMed 15643603}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000337435	ENSP00000337452; ENSG00000170113. [Q7RTP0-1]
# Ensembl	ENST00000437912	ENSP00000393962; ENSG00000170113. [Q7RTP0-2]
# Ensembl	ENST00000561183	ENSP00000453722; ENSG00000170113. [Q7RTP0-2]
# ExpressionAtlas	Q7RTP0	baseline and differential
# FUNCTION	NIPA1_HUMAN	Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). {ECO 0000250}. 
# GO_component	GO:0005769	early endosome; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016020	membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015095	magnesium ion transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0015693	magnesium ion transport; IBA:GO_Central.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q7RTP0	HS
# HGNC	HGNC:17043	NIPA1
# InterPro	IPR008521	Mg_trans_NIPA
# KEGG_Disease	H00266	[Nervous system disease; Muscular disease] Hereditary spastic paraplegia (SPG)
# MIM	600363	phenotype
# MIM	608145	gene
# Organism	NIPA1_HUMAN	Homo sapiens (Human)
# Orphanet	100988	Autosomal dominant spastic paraplegia type 6
# PANTHER	PTHR12570	PTHR12570
# Pfam	PF05653	Mg_trans_NIPA
# Proteomes	UP000005640	Chromosome 15
# Reactome	R-HSA-5223345	Miscellaneous transport and binding events
# RecName	NIPA1_HUMAN	Magnesium transporter NIPA1
# RefSeq	NP_001135747	NM_001142275.1. [Q7RTP0-2]
# RefSeq	NP_653200	NM_144599.4. [Q7RTP0-1]
# SEQUENCE CAUTION	Sequence=BAC67707.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC67707.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the NIPA family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	NIPA1_HUMAN	Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. Early endosome {ECO 0000250}. Note=Recruited to the cell membrane in response to low extracellular magnesium. {ECO 0000250}. 
# SUBUNIT	Homodimer. {ECO	0000250}. 
# TCDB	2.A.7.25	the drug/metabolite transporter (dmt) superfamily
# TISSUE SPECIFICITY	Widely expressed with highest levels in neuronal tissues. {ECO:0000269|PubMed	14508710}. 
# UCSC	uc001yvc	human. [Q7RTP0-1]
# eggNOG	ENOG410XNR8	LUCA
# eggNOG	KOG2922	Eukaryota
BLAST	swissprot:NIPA1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NIPA1_HUMAN
COXPRESdb	123606	http://coxpresdb.jp/data/gene/123606.shtml
CleanEx	HS_NIPA1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_NIPA1
DOI	10.1002/humu.20126	http://dx.doi.org/10.1002/humu.20126
DOI	10.1021/pr0502065	http://dx.doi.org/10.1021/pr0502065
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1086/378816	http://dx.doi.org/10.1086/378816
DOI	10.1086/378817	http://dx.doi.org/10.1086/378817
DOI	10.1101/gr.709603	http://dx.doi.org/10.1101/gr.709603
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AB089319	http://www.ebi.ac.uk/ena/data/view/AB089319
EMBL	AK314073	http://www.ebi.ac.uk/ena/data/view/AK314073
EMBL	BK001020	http://www.ebi.ac.uk/ena/data/view/BK001020
EMBL	BX537997	http://www.ebi.ac.uk/ena/data/view/BX537997
EMBL	BX648722	http://www.ebi.ac.uk/ena/data/view/BX648722
EMBL	CH471258	http://www.ebi.ac.uk/ena/data/view/CH471258
EMBL	CR614719	http://www.ebi.ac.uk/ena/data/view/CR614719
Ensembl	ENST00000337435	http://www.ensembl.org/id/ENST00000337435
Ensembl	ENST00000437912	http://www.ensembl.org/id/ENST00000437912
Ensembl	ENST00000561183	http://www.ensembl.org/id/ENST00000561183
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005769	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005769
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015095
GO_process	GO:0015693	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015693
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	NIPA1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=NIPA1
GeneID	123606	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=123606
GeneTree	ENSGT00550000074395	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074395
HGNC	HGNC:17043	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17043
HOGENOM	HOG000203962	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000203962&db=HOGENOM6
HOVERGEN	HBG055032	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG055032&db=HOVERGEN
HPA	HPA023269	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA023269
InParanoid	Q7RTP0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q7RTP0
InterPro	IPR008521	http://www.ebi.ac.uk/interpro/entry/IPR008521
Jabion	123606	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=123606
KEGG_Disease	H00266	http://www.genome.jp/dbget-bin/www_bget?H00266
KEGG_Gene	hsa:123606	http://www.genome.jp/dbget-bin/www_bget?hsa:123606
MIM	600363	http://www.ncbi.nlm.nih.gov/omim/600363
MIM	608145	http://www.ncbi.nlm.nih.gov/omim/608145
OMA	EWSNVGV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EWSNVGV
Orphanet	100988	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=100988
OrthoDB	EOG091G0M8A	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0M8A
PANTHER	PTHR12570	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12570
PSORT	swissprot:NIPA1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NIPA1_HUMAN
PSORT-B	swissprot:NIPA1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NIPA1_HUMAN
PSORT2	swissprot:NIPA1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NIPA1_HUMAN
Pfam	PF05653	http://pfam.xfam.org/family/PF05653
PharmGKB	PA134967361	http://www.pharmgkb.org/do/serve?objId=PA134967361&objCls=Gene
Phobius	swissprot:NIPA1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NIPA1_HUMAN
PhylomeDB	Q7RTP0	http://phylomedb.org/?seqid=Q7RTP0
ProteinModelPortal	Q7RTP0	http://www.proteinmodelportal.org/query/uniprot/Q7RTP0
PubMed	12805275	http://www.ncbi.nlm.nih.gov/pubmed/12805275
PubMed	14508708	http://www.ncbi.nlm.nih.gov/pubmed/14508708
PubMed	14508710	http://www.ncbi.nlm.nih.gov/pubmed/14508710
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15643603	http://www.ncbi.nlm.nih.gov/pubmed/15643603
PubMed	16335952	http://www.ncbi.nlm.nih.gov/pubmed/16335952
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
Reactome	R-HSA-5223345	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5223345
RefSeq	NP_001135747	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001135747
RefSeq	NP_653200	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_653200
STRING	9606.ENSP00000337452	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000337452&targetmode=cogs
TCDB	2.A.7.25	http://www.tcdb.org/search/result.php?tc=2.A.7.25
UCSC	uc001yvc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001yvc&org=rat
UniGene	Hs.511797	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.511797
UniProtKB	NIPA1_HUMAN	http://www.uniprot.org/uniprot/NIPA1_HUMAN
UniProtKB-AC	Q7RTP0	http://www.uniprot.org/uniprot/Q7RTP0
charge	swissprot:NIPA1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NIPA1_HUMAN
eggNOG	ENOG410XNR8	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNR8
eggNOG	KOG2922	http://eggnogapi.embl.de/nog_data/html/tree/KOG2922
epestfind	swissprot:NIPA1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NIPA1_HUMAN
garnier	swissprot:NIPA1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NIPA1_HUMAN
helixturnhelix	swissprot:NIPA1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NIPA1_HUMAN
hmoment	swissprot:NIPA1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NIPA1_HUMAN
iep	swissprot:NIPA1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NIPA1_HUMAN
inforesidue	swissprot:NIPA1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NIPA1_HUMAN
neXtProt	NX_Q7RTP0	http://www.nextprot.org/db/entry/NX_Q7RTP0
octanol	swissprot:NIPA1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NIPA1_HUMAN
pepcoil	swissprot:NIPA1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NIPA1_HUMAN
pepdigest	swissprot:NIPA1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NIPA1_HUMAN
pepinfo	swissprot:NIPA1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NIPA1_HUMAN
pepnet	swissprot:NIPA1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NIPA1_HUMAN
pepstats	swissprot:NIPA1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NIPA1_HUMAN
pepwheel	swissprot:NIPA1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NIPA1_HUMAN
pepwindow	swissprot:NIPA1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NIPA1_HUMAN
sigcleave	swissprot:NIPA1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NIPA1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	PKD1_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P98161-1; Sequence=Displayed; Name=2; IsoId=P98161-2; Sequence=VSP_009677, VSP_009678; Name=3; IsoId=P98161-3; Sequence=VSP_009678; 
# AltName	PKD1_HUMAN	Autosomal dominant polycystic kidney disease 1 protein
# BioGrid	111327	19
# CAUTION	PKD1_HUMAN	Variant Cys-2379 has been originally described as a benign polymorphism (PubMed 10854095). However, it is a likely pathogenic mutation (PubMed 22508176). {ECO 0000305|PubMed 10854095, ECO 0000305|PubMed 22508176}. 
# CCDS	CCDS32369	-. [P98161-1]
# CCDS	CCDS45385	-. [P98161-3]
# DISEASE	PKD1_HUMAN	Polycystic kidney disease 1 (PKD1) [MIM 173900]  A disorder characterized by renal cysts, liver cysts and intracranial aneurysm. Clinical variability is due to differences in the rate of loss of glomerular filtration, the age of reaching end-stage renal disease and the occurrence of hypertension, symptomatic extrarenal cysts, and subarachnoid hemorrhage from intracranial 'berry' aneurysm. {ECO 0000269|PubMed 10200984, ECO 0000269|PubMed 10364515, ECO 0000269|PubMed 10577909, ECO 0000269|PubMed 10647901, ECO 0000269|PubMed 10729710, ECO 0000269|PubMed 10854095, ECO 0000269|PubMed 10923040, ECO 0000269|PubMed 10987650, ECO 0000269|PubMed 11012875, ECO 0000269|PubMed 11058904, ECO 0000269|PubMed 11115377, ECO 0000269|PubMed 11216660, ECO 0000269|PubMed 11316854, ECO 0000269|PubMed 11558899, ECO 0000269|PubMed 11571556, ECO 0000269|PubMed 11691639, ECO 0000269|PubMed 11773467, ECO 0000269|PubMed 11857740, ECO 0000269|PubMed 11967008, ECO 0000269|PubMed 12007219, ECO 0000269|PubMed 12070253, ECO 0000269|PubMed 12220456, ECO 0000269|PubMed 12842373, ECO 0000269|PubMed 15772804, ECO 0000269|PubMed 18837007, ECO 0000269|PubMed 21115670, ECO 0000269|PubMed 22508176, ECO 0000269|PubMed 8554072, ECO 0000269|PubMed 9199561, ECO 0000269|PubMed 9259200, ECO 0000269|PubMed 9285784, ECO 0000269|PubMed 9521593, ECO 0000269|PubMed 9921908}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	PKD1_HUMAN	The LDL-receptor class A domain is atypical; the potential calcium-binding site is missing. 
# Ensembl	ENST00000262304	ENSP00000262304; ENSG00000008710. [P98161-1]
# Ensembl	ENST00000423118	ENSP00000399501; ENSG00000008710. [P98161-3]
# ExpressionAtlas	P98161	baseline and differential
# FUNCTION	PKD1_HUMAN	Involved in renal tubulogenesis (PubMed 12482949). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling (By similarity). The cilium length response creates a negative feedback loop whereby fluid shear- mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). May be an ion-channel regulator. Involved in adhesive protein-protein and protein- carbohydrate interactions. {ECO 0000250|UniProtKB O08852, ECO 0000269|PubMed 12482949}. 
# GO_component	GO:0000139	Golgi membrane; TAS:Reactome.
# GO_component	GO:0002133	polycystin complex; ISS:BHF-UCL.
# GO_component	GO:0005634	nucleus; ISS:BHF-UCL.
# GO_component	GO:0005737	cytoplasm; ISS:BHF-UCL.
# GO_component	GO:0005886	plasma membrane; IDA:MGI.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0005929	cilium; ISS:UniProtKB.
# GO_component	GO:0009986	cell surface; IEA:Ensembl.
# GO_component	GO:0016021	integral component of membrane; NAS:BHF-UCL.
# GO_component	GO:0016323	basolateral plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0016328	lateral plasma membrane; IEA:Ensembl.
# GO_component	GO:0030660	Golgi-associated vesicle membrane; TAS:Reactome.
# GO_component	GO:0031514	motile cilium; ISS:BHF-UCL.
# GO_component	GO:0060170	ciliary membrane; TAS:Reactome.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005262	calcium channel activity; ISS:BHF-UCL.
# GO_function	GO:0019901	protein kinase binding; IPI:UniProtKB.
# GO_function	GO:0019904	protein domain specific binding; IPI:BHF-UCL.
# GO_function	GO:0030246	carbohydrate binding; IEA:UniProtKB-KW.
# GO_function	GO:0044325	ion channel binding; IPI:BHF-UCL.
# GO_process	GO:0001502	cartilage condensation; IEA:Ensembl.
# GO_process	GO:0001701	in utero embryonic development; ISS:BHF-UCL.
# GO_process	GO:0001822	kidney development; ISS:BHF-UCL.
# GO_process	GO:0001889	liver development; IEA:Ensembl.
# GO_process	GO:0001892	embryonic placenta development; ISS:BHF-UCL.
# GO_process	GO:0006611	protein export from nucleus; ISS:BHF-UCL.
# GO_process	GO:0006807	nitrogen compound metabolic process; IEA:Ensembl.
# GO_process	GO:0007050	cell cycle arrest; ISS:BHF-UCL.
# GO_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules; TAS:ProtInc.
# GO_process	GO:0007160	cell-matrix adhesion; TAS:ProtInc.
# GO_process	GO:0007161	calcium-independent cell-matrix adhesion; TAS:ProtInc.
# GO_process	GO:0007204	positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
# GO_process	GO:0007259	JAK-STAT cascade; ISS:BHF-UCL.
# GO_process	GO:0007507	heart development; IEP:UniProtKB.
# GO_process	GO:0009653	anatomical structure morphogenesis; TAS:ProtInc.
# GO_process	GO:0016337	single organismal cell-cell adhesion; IEA:Ensembl.
# GO_process	GO:0018105	peptidyl-serine phosphorylation; ISS:BHF-UCL.
# GO_process	GO:0021510	spinal cord development; IEP:UniProtKB.
# GO_process	GO:0021915	neural tube development; IEP:UniProtKB.
# GO_process	GO:0030010	establishment of cell polarity; IEA:Ensembl.
# GO_process	GO:0030155	regulation of cell adhesion; IEA:Ensembl.
# GO_process	GO:0031659	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; IDA:BHF-UCL.
# GO_process	GO:0032092	positive regulation of protein binding; ISS:BHF-UCL.
# GO_process	GO:0034405	response to fluid shear stress; IEA:Ensembl.
# GO_process	GO:0036303	lymph vessel morphogenesis; IEA:Ensembl.
# GO_process	GO:0042994	cytoplasmic sequestering of transcription factor; ISS:BHF-UCL.
# GO_process	GO:0043588	skin development; IEP:UniProtKB.
# GO_process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
# GO_process	GO:0048565	digestive tract development; IEP:UniProtKB.
# GO_process	GO:0048754	branching morphogenesis of an epithelial tube; IDA:UniProtKB.
# GO_process	GO:0048806	genitalia development; IEP:UniProtKB.
# GO_process	GO:0050982	detection of mechanical stimulus; ISS:BHF-UCL.
# GO_process	GO:0051216	cartilage development; IEP:UniProtKB.
# GO_process	GO:0060236	regulation of mitotic spindle organization; IEA:Ensembl.
# GO_process	GO:0060428	lung epithelium development; IEP:UniProtKB.
# GO_process	GO:0060674	placenta blood vessel development; ISS:BHF-UCL.
# GO_process	GO:0061136	regulation of proteasomal protein catabolic process; IDA:MGI.
# GO_process	GO:0070588	calcium ion transmembrane transport; ISS:BHF-UCL.
# GO_process	GO:0072164	mesonephric tubule development; IEP:UniProtKB.
# GO_process	GO:0072177	mesonephric duct development; IEP:UniProtKB.
# GO_process	GO:0072205	metanephric collecting duct development; IEP:UniProtKB.
# GO_process	GO:0072218	metanephric ascending thin limb development; IEP:UniProtKB.
# GO_process	GO:0072237	metanephric proximal tubule development; IEP:UniProtKB.
# GO_process	GO:0072287	metanephric distal tubule morphogenesis; IEP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0005929	cilium
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007155	cell adhesion
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009790	embryo development
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.40.670	-; 14.
# Gene3D	2.60.60.20	-; 1.
# Gene3D	3.10.100.10	-; 2.
# Gene3D	3.80.10.10	-; 1.
# Genevisible	P98161	HS
# HGNC	HGNC:9008	PKD1
# INTERACTION	PKD1_HUMAN	O15259 NPHP1; NbExp=2; IntAct=EBI-1752013, EBI-953828; Q13563 PKD2; NbExp=8; IntAct=EBI-1752013, EBI-7813714; 
# IntAct	P98161	7
# InterPro	IPR000203	GPS
# InterPro	IPR000372	LRRNT
# InterPro	IPR000434	PC1
# InterPro	IPR000483	Cys-rich_flank_reg_C
# InterPro	IPR000601	PKD_dom
# InterPro	IPR001024	PLAT/LH2_dom
# InterPro	IPR001304	C-type_lectin-like
# InterPro	IPR001611	Leu-rich_rpt
# InterPro	IPR002859	PKD/REJ-like
# InterPro	IPR002889	WSC_carb-bd
# InterPro	IPR003591	Leu-rich_rpt_typical-subtyp
# InterPro	IPR006228	Polycystin_cat
# InterPro	IPR013122	PKD1_2_channel
# InterPro	IPR014010	REJ_dom
# InterPro	IPR016186	C-type_lectin-like/link
# InterPro	IPR016187	CTDL_fold
# InterPro	IPR022409	PKD/Chitinase_dom
# InterPro	IPR032675	L_dom-like
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Brite	ko04812	Cytoskeleton proteins
# KEGG_Disease	H00542	[Developmental disorder; Kidney disease; Liver disease] Polycystic kidney disease
# MIM	173900	phenotype
# MIM	601313	gene+phenotype
# Organism	PKD1_HUMAN	Homo sapiens (Human)
# Orphanet	730	Autosomal dominant polycystic kidney disease
# Orphanet	88924	Autosomal dominant polycystic kidney disease type 1 with tuberous sclerosis
# PDB	1B4R	NMR; -; A=275-354
# PIR	A38971	A38971
# PRINTS	PR00500	POLYCYSTIN1
# PROSITE	PS50041	C_TYPE_LECTIN_2
# PROSITE	PS50093	PKD; 12
# PROSITE	PS50095	PLAT
# PROSITE	PS50221	GPS
# PROSITE	PS51111	REJ
# PROSITE	PS51212	WSC
# PROSITE	PS51450	LRR; 2
# PTM	PKD1_HUMAN	After synthesis, undergoes cleavage between Leu-3048 and Thr- 3049 in the GPS domain. Cleavage at the GPS domain occurs through a cis-autoproteolytic mechanism involving an ester-intermediate via N-O acyl rearrangement. This process takes place in the early secretory pathway, depends on initial N-glycosylation, and requires the REJ domain. There is evidence that cleavage at GPS domain is incomplete. Uncleaved and cleaved products may have different functions in vivo. {ECO 0000269|PubMed 12482949}. 
# Pfam	PF00059	Lectin_C
# Pfam	PF00801	PKD; 15
# Pfam	PF01477	PLAT
# Pfam	PF01822	WSC
# Pfam	PF02010	REJ
# Pfam	PF08016	PKD_channel
# Pfam	PF13855	LRR_8
# Proteomes	UP000005640	Chromosome 16
# Reactome	R-HSA-5620916	VxPx cargo-targeting to cilium
# RecName	PKD1_HUMAN	Polycystin-1
# RefSeq	NP_000287	NM_000296.3
# RefSeq	NP_001009944	NM_001009944.2
# SIMILARITY	Belongs to the polycystin family. {ECO	0000305}. 
# SIMILARITY	Contains 1 C-type lectin domain. {ECO:0000255|PROSITE- ProRule	PRU00040}. 
# SIMILARITY	Contains 1 GPS domain. {ECO:0000255|PROSITE- ProRule	PRU00098}. 
# SIMILARITY	Contains 1 LDL-receptor class A domain. {ECO	0000305}. 
# SIMILARITY	Contains 1 LRRCT domain. {ECO	0000305}. 
# SIMILARITY	Contains 1 LRRNT domain. {ECO	0000305}. 
# SIMILARITY	Contains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule	PRU00152}. 
# SIMILARITY	Contains 1 REJ domain. {ECO:0000255|PROSITE- ProRule	PRU00511}. 
# SIMILARITY	Contains 1 WSC domain. {ECO:0000255|PROSITE- ProRule	PRU00558}. 
# SIMILARITY	Contains 17 PKD domains. {ECO:0000255|PROSITE- ProRule	PRU00151}. 
# SIMILARITY	Contains 2 LRR (leucine-rich) repeats. {ECO	0000305}. 
# SMART	SM00013	LRRNT
# SMART	SM00034	CLECT
# SMART	SM00082	LRRCT
# SMART	SM00089	PKD; 15
# SMART	SM00303	GPS
# SMART	SM00308	LH2
# SMART	SM00321	WSC
# SMART	SM00369	LRR_TYP; 2
# SUBCELLULAR LOCATION	PKD1_HUMAN	Cell membrane {ECO 0000269|PubMed 10339594, ECO 0000269|PubMed 20980620}; Multi-pass membrane protein {ECO 0000269|PubMed 20980620}. Cell projection, cilium {ECO 0000250|UniProtKB O08852}. Note=PKD1 localization to the plasma and ciliary membranes requires PKD2, is independent of PKD2 channel activity, and involves stimulation of PKD1 autoproteolytic cleavage at the GPS domain (By similarity). Ciliary localization of PKD1 requires BBS1 and ARL6/BBS3 (By similarity). {ECO 0000250|UniProtKB O08852}. 
# SUBUNIT	PKD1_HUMAN	Interacts with PKD2 and PKD2L1 (By similarity). Interacts with PRKX; involved in differentiation and controlled morphogenesis of the kidney (PubMed 17980165). Interacts with NPHP1 (via SH3 domain) (PubMed 20856870). Interacts with BBS1, BBS4, BBS5 and TTC8 (PubMed 24939912). Interacts with RGS7 (PubMed 10339594). {ECO 0000250|UniProtKB O08852, ECO 0000269|PubMed 10339594, ECO 0000269|PubMed 17980165, ECO 0000269|PubMed 20856870, ECO 0000269|PubMed 24939912}. 
# SUPFAM	SSF49299	SSF49299; 13
# SUPFAM	SSF49723	SSF49723
# SUPFAM	SSF52058	SSF52058
# SUPFAM	SSF56436	SSF56436
# TCDB	1.A.5.1	the polycystin cation channel (pcc) family
# TIGRFAMs	TIGR00864	PCC
# UCSC	uc002cos	human. [P98161-1]
# WEB RESOURCE	PKD1_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/PKD1ID41725ch16p13.html";
# WEB RESOURCE	PKD1_HUMAN	Name=Functional Glycomics Gateway - Glycan Binding; Note=Polycystin-1; URL="http //www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_204"; 
# eggNOG	ENOG410XTGE	LUCA
# eggNOG	KOG3599	Eukaryota
BLAST	swissprot:PKD1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:PKD1_HUMAN
BioCyc	ZFISH:ENSG00000008710-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000008710-MONOMER
COXPRESdb	5310	http://coxpresdb.jp/data/gene/5310.shtml
CleanEx	HS_PKD1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_PKD1
DIP	DIP-52317N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-52317N
DOI	10.1002/(SICI)1098-1004(1997)10:2<164::AID-HUMU9>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1997)10:2<164::AID-HUMU9>3.0.CO
DOI	10.1002/1098-1004(200008)16:2<176::AID-HUMU11>3.0.CO	http://dx.doi.org/10.1002/1098-1004(200008)16:2<176::AID-HUMU11>3.0.CO
DOI	10.1002/1098-1004(200011)16:5<444::AID-HUMU11>3.0.CO	http://dx.doi.org/10.1002/1098-1004(200011)16:5<444::AID-HUMU11>3.0.CO
DOI	10.1002/humu.10045	http://dx.doi.org/10.1002/humu.10045
DOI	10.1002/humu.10080	http://dx.doi.org/10.1002/humu.10080
DOI	10.1002/humu.20842	http://dx.doi.org/10.1002/humu.20842
DOI	10.1002/humu.22103	http://dx.doi.org/10.1002/humu.22103
DOI	10.1007/s00109-005-0644-6	http://dx.doi.org/10.1007/s00109-005-0644-6
DOI	10.1007/s004390050421	http://dx.doi.org/10.1007/s004390050421
DOI	10.1007/s004390050681	http://dx.doi.org/10.1007/s004390050681
DOI	10.1007/s004390050896	http://dx.doi.org/10.1007/s004390050896
DOI	10.1007/s004390051094	http://dx.doi.org/10.1007/s004390051094
DOI	10.1007/s004399900177	http://dx.doi.org/10.1007/s004399900177
DOI	10.1007/s100380170032	http://dx.doi.org/10.1007/s100380170032
DOI	10.1016/S0027-5107(01)00226-3	http://dx.doi.org/10.1016/S0027-5107(01)00226-3
DOI	10.1016/S0140-6736(03)13773-7	http://dx.doi.org/10.1016/S0140-6736(03)13773-7
DOI	10.1016/S0165-6147(00)01832-0	http://dx.doi.org/10.1016/S0165-6147(00)01832-0
DOI	10.1016/S1383-5726(99)00013-8	http://dx.doi.org/10.1016/S1383-5726(99)00013-8
DOI	10.1016/j.bbadis.2007.09.003	http://dx.doi.org/10.1016/j.bbadis.2007.09.003
DOI	10.1034/j.1399-0004.2002.620211.x	http://dx.doi.org/10.1034/j.1399-0004.2002.620211.x
DOI	10.1038/nature03187	http://dx.doi.org/10.1038/nature03187
DOI	10.1038/ng0695-151	http://dx.doi.org/10.1038/ng0695-151
DOI	10.1038/sj.ejhg.5200459	http://dx.doi.org/10.1038/sj.ejhg.5200459
DOI	10.1038/sj.ejhg.5200696	http://dx.doi.org/10.1038/sj.ejhg.5200696
DOI	10.1046/j.1523-1755.1999.00368.x	http://dx.doi.org/10.1046/j.1523-1755.1999.00368.x
DOI	10.1046/j.1523-1755.2000.00302.x	http://dx.doi.org/10.1046/j.1523-1755.2000.00302.x
DOI	10.1046/j.1523-1755.2002.00326.x	http://dx.doi.org/10.1046/j.1523-1755.2002.00326.x
DOI	10.1073/pnas.252484899	http://dx.doi.org/10.1073/pnas.252484899
DOI	10.1073/pnas.96.11.6371	http://dx.doi.org/10.1073/pnas.96.11.6371
DOI	10.1074/jbc.M703218200	http://dx.doi.org/10.1074/jbc.M703218200
DOI	10.1086/302460	http://dx.doi.org/10.1086/302460
DOI	10.1086/302657	http://dx.doi.org/10.1086/302657
DOI	10.1086/316939	http://dx.doi.org/10.1086/316939
DOI	10.1086/515467	http://dx.doi.org/10.1086/515467
DOI	10.1089/109065700750065108	http://dx.doi.org/10.1089/109065700750065108
DOI	10.1091/mbc.E10-05-0407	http://dx.doi.org/10.1091/mbc.E10-05-0407
DOI	10.1093/emboj/18.2.297	http://dx.doi.org/10.1093/emboj/18.2.297
DOI	10.1093/hmg/6.9.1473	http://dx.doi.org/10.1093/hmg/6.9.1473
DOI	10.1093/hmg/ddu267	http://dx.doi.org/10.1093/hmg/ddu267
DOI	10.1093/ndt/17.1.75	http://dx.doi.org/10.1093/ndt/17.1.75
DOI	10.1093/ndt/gfq720	http://dx.doi.org/10.1093/ndt/gfq720
DOI	10.1136/jmg.39.6.422	http://dx.doi.org/10.1136/jmg.39.6.422
DOI	10.1371/journal.pone.0012719	http://dx.doi.org/10.1371/journal.pone.0012719
EMBL	AC009065	http://www.ebi.ac.uk/ena/data/view/AC009065
EMBL	AC093513	http://www.ebi.ac.uk/ena/data/view/AC093513
EMBL	L33243	http://www.ebi.ac.uk/ena/data/view/L33243
EMBL	L43601	http://www.ebi.ac.uk/ena/data/view/L43601
EMBL	L43602	http://www.ebi.ac.uk/ena/data/view/L43602
EMBL	L43604	http://www.ebi.ac.uk/ena/data/view/L43604
EMBL	L43605	http://www.ebi.ac.uk/ena/data/view/L43605
EMBL	L43610	http://www.ebi.ac.uk/ena/data/view/L43610
EMBL	L43617	http://www.ebi.ac.uk/ena/data/view/L43617
EMBL	L43618	http://www.ebi.ac.uk/ena/data/view/L43618
EMBL	L43619	http://www.ebi.ac.uk/ena/data/view/L43619
EMBL	U24497	http://www.ebi.ac.uk/ena/data/view/U24497
Ensembl	ENST00000262304	http://www.ensembl.org/id/ENST00000262304
Ensembl	ENST00000423118	http://www.ensembl.org/id/ENST00000423118
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0002133	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002133
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005929	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005929
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0016328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016328
GO_component	GO:0030660	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030660
GO_component	GO:0031514	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031514
GO_component	GO:0060170	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060170
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0019901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019901
GO_function	GO:0019904	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019904
GO_function	GO:0030246	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030246
GO_function	GO:0044325	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044325
GO_process	GO:0001502	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001502
GO_process	GO:0001701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001701
GO_process	GO:0001822	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001822
GO_process	GO:0001889	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001889
GO_process	GO:0001892	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001892
GO_process	GO:0006611	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006611
GO_process	GO:0006807	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006807
GO_process	GO:0007050	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007050
GO_process	GO:0007156	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007156
GO_process	GO:0007160	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007160
GO_process	GO:0007161	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007161
GO_process	GO:0007204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007204
GO_process	GO:0007259	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007259
GO_process	GO:0007507	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007507
GO_process	GO:0009653	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009653
GO_process	GO:0016337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016337
GO_process	GO:0018105	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018105
GO_process	GO:0021510	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021510
GO_process	GO:0021915	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021915
GO_process	GO:0030010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030010
GO_process	GO:0030155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030155
GO_process	GO:0031659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031659
GO_process	GO:0032092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032092
GO_process	GO:0034405	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034405
GO_process	GO:0036303	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036303
GO_process	GO:0042994	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042994
GO_process	GO:0043588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043588
GO_process	GO:0045944	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045944
GO_process	GO:0048565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048565
GO_process	GO:0048754	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048754
GO_process	GO:0048806	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048806
GO_process	GO:0050982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050982
GO_process	GO:0051216	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051216
GO_process	GO:0060236	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060236
GO_process	GO:0060428	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060428
GO_process	GO:0060674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060674
GO_process	GO:0061136	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061136
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:0072164	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072164
GO_process	GO:0072177	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072177
GO_process	GO:0072205	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072205
GO_process	GO:0072218	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072218
GO_process	GO:0072237	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072237
GO_process	GO:0072287	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072287
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0005929	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005929
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009790
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.40.670	http://www.cathdb.info/version/latest/superfamily/2.60.40.670
Gene3D	2.60.60.20	http://www.cathdb.info/version/latest/superfamily/2.60.60.20
Gene3D	3.10.100.10	http://www.cathdb.info/version/latest/superfamily/3.10.100.10
Gene3D	3.80.10.10	http://www.cathdb.info/version/latest/superfamily/3.80.10.10
GeneCards	PKD1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=PKD1
GeneID	5310	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5310
GeneTree	ENSGT00700000104221	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00700000104221
H-InvDB	HIX0173395	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0173395
H-InvDB	HIX0202314	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0202314
HGNC	HGNC:9008	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:9008
HOGENOM	HOG000168445	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000168445&db=HOGENOM6
HOVERGEN	HBG049412	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG049412&db=HOVERGEN
HPA	CAB046448	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB046448
InParanoid	P98161	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P98161
IntAct	P98161	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P98161*
InterPro	IPR000203	http://www.ebi.ac.uk/interpro/entry/IPR000203
InterPro	IPR000372	http://www.ebi.ac.uk/interpro/entry/IPR000372
InterPro	IPR000434	http://www.ebi.ac.uk/interpro/entry/IPR000434
InterPro	IPR000483	http://www.ebi.ac.uk/interpro/entry/IPR000483
InterPro	IPR000601	http://www.ebi.ac.uk/interpro/entry/IPR000601
InterPro	IPR001024	http://www.ebi.ac.uk/interpro/entry/IPR001024
InterPro	IPR001304	http://www.ebi.ac.uk/interpro/entry/IPR001304
InterPro	IPR001611	http://www.ebi.ac.uk/interpro/entry/IPR001611
InterPro	IPR002859	http://www.ebi.ac.uk/interpro/entry/IPR002859
InterPro	IPR002889	http://www.ebi.ac.uk/interpro/entry/IPR002889
InterPro	IPR003591	http://www.ebi.ac.uk/interpro/entry/IPR003591
InterPro	IPR006228	http://www.ebi.ac.uk/interpro/entry/IPR006228
InterPro	IPR013122	http://www.ebi.ac.uk/interpro/entry/IPR013122
InterPro	IPR014010	http://www.ebi.ac.uk/interpro/entry/IPR014010
InterPro	IPR016186	http://www.ebi.ac.uk/interpro/entry/IPR016186
InterPro	IPR016187	http://www.ebi.ac.uk/interpro/entry/IPR016187
InterPro	IPR022409	http://www.ebi.ac.uk/interpro/entry/IPR022409
InterPro	IPR032675	http://www.ebi.ac.uk/interpro/entry/IPR032675
Jabion	5310	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=5310
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Brite	ko04812	http://www.genome.jp/dbget-bin/www_bget?ko04812
KEGG_Disease	H00542	http://www.genome.jp/dbget-bin/www_bget?H00542
KEGG_Gene	hsa:5310	http://www.genome.jp/dbget-bin/www_bget?hsa:5310
KEGG_Orthology	KO:K04985	http://www.genome.jp/dbget-bin/www_bget?KO:K04985
MIM	173900	http://www.ncbi.nlm.nih.gov/omim/173900
MIM	601313	http://www.ncbi.nlm.nih.gov/omim/601313
MINT	MINT-1199187	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1199187
OMA	VSCKAQS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VSCKAQS
Orphanet	730	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=730
Orphanet	88924	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=88924
OrthoDB	EOG091G004D	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G004D
PDB	1B4R	http://www.ebi.ac.uk/pdbe-srv/view/entry/1B4R
PDBsum	1B4R	http://www.ebi.ac.uk/pdbsum/1B4R
PRINTS	PR00500	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00500
PROSITE	PS50041	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50041
PROSITE	PS50093	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50093
PROSITE	PS50095	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50095
PROSITE	PS50221	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50221
PROSITE	PS51111	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51111
PROSITE	PS51212	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51212
PROSITE	PS51450	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51450
PSORT	swissprot:PKD1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:PKD1_HUMAN
PSORT-B	swissprot:PKD1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:PKD1_HUMAN
PSORT2	swissprot:PKD1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:PKD1_HUMAN
Pfam	PF00059	http://pfam.xfam.org/family/PF00059
Pfam	PF00801	http://pfam.xfam.org/family/PF00801
Pfam	PF01477	http://pfam.xfam.org/family/PF01477
Pfam	PF01822	http://pfam.xfam.org/family/PF01822
Pfam	PF02010	http://pfam.xfam.org/family/PF02010
Pfam	PF08016	http://pfam.xfam.org/family/PF08016
Pfam	PF13855	http://pfam.xfam.org/family/PF13855
PharmGKB	PA35521	http://www.pharmgkb.org/do/serve?objId=PA35521&objCls=Gene
Phobius	swissprot:PKD1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:PKD1_HUMAN
PhylomeDB	P98161	http://phylomedb.org/?seqid=P98161
ProteinModelPortal	P98161	http://www.proteinmodelportal.org/query/uniprot/P98161
PubMed	10200984	http://www.ncbi.nlm.nih.gov/pubmed/10200984
PubMed	10339594	http://www.ncbi.nlm.nih.gov/pubmed/10339594
PubMed	10364515	http://www.ncbi.nlm.nih.gov/pubmed/10364515
PubMed	10577909	http://www.ncbi.nlm.nih.gov/pubmed/10577909
PubMed	10647901	http://www.ncbi.nlm.nih.gov/pubmed/10647901
PubMed	10729710	http://www.ncbi.nlm.nih.gov/pubmed/10729710
PubMed	10854095	http://www.ncbi.nlm.nih.gov/pubmed/10854095
PubMed	10923040	http://www.ncbi.nlm.nih.gov/pubmed/10923040
PubMed	10987650	http://www.ncbi.nlm.nih.gov/pubmed/10987650
PubMed	11012875	http://www.ncbi.nlm.nih.gov/pubmed/11012875
PubMed	11058904	http://www.ncbi.nlm.nih.gov/pubmed/11058904
PubMed	11115377	http://www.ncbi.nlm.nih.gov/pubmed/11115377
PubMed	11216660	http://www.ncbi.nlm.nih.gov/pubmed/11216660
PubMed	11316854	http://www.ncbi.nlm.nih.gov/pubmed/11316854
PubMed	11558899	http://www.ncbi.nlm.nih.gov/pubmed/11558899
PubMed	11571556	http://www.ncbi.nlm.nih.gov/pubmed/11571556
PubMed	11691639	http://www.ncbi.nlm.nih.gov/pubmed/11691639
PubMed	11698076	http://www.ncbi.nlm.nih.gov/pubmed/11698076
PubMed	11773467	http://www.ncbi.nlm.nih.gov/pubmed/11773467
PubMed	11857740	http://www.ncbi.nlm.nih.gov/pubmed/11857740
PubMed	11967008	http://www.ncbi.nlm.nih.gov/pubmed/11967008
PubMed	12007219	http://www.ncbi.nlm.nih.gov/pubmed/12007219
PubMed	12070253	http://www.ncbi.nlm.nih.gov/pubmed/12070253
PubMed	12220456	http://www.ncbi.nlm.nih.gov/pubmed/12220456
PubMed	12482949	http://www.ncbi.nlm.nih.gov/pubmed/12482949
PubMed	12842373	http://www.ncbi.nlm.nih.gov/pubmed/12842373
PubMed	15616553	http://www.ncbi.nlm.nih.gov/pubmed/15616553
PubMed	15772804	http://www.ncbi.nlm.nih.gov/pubmed/15772804
PubMed	17525154	http://www.ncbi.nlm.nih.gov/pubmed/17525154
PubMed	17980165	http://www.ncbi.nlm.nih.gov/pubmed/17980165
PubMed	18837007	http://www.ncbi.nlm.nih.gov/pubmed/18837007
PubMed	20856870	http://www.ncbi.nlm.nih.gov/pubmed/20856870
PubMed	20980620	http://www.ncbi.nlm.nih.gov/pubmed/20980620
PubMed	21115670	http://www.ncbi.nlm.nih.gov/pubmed/21115670
PubMed	22508176	http://www.ncbi.nlm.nih.gov/pubmed/22508176
PubMed	24939912	http://www.ncbi.nlm.nih.gov/pubmed/24939912
PubMed	7663510	http://www.ncbi.nlm.nih.gov/pubmed/7663510
PubMed	7736581	http://www.ncbi.nlm.nih.gov/pubmed/7736581
PubMed	8004675	http://www.ncbi.nlm.nih.gov/pubmed/8004675
PubMed	8069919	http://www.ncbi.nlm.nih.gov/pubmed/8069919
PubMed	8554072	http://www.ncbi.nlm.nih.gov/pubmed/8554072
PubMed	9150733	http://www.ncbi.nlm.nih.gov/pubmed/9150733
PubMed	9199561	http://www.ncbi.nlm.nih.gov/pubmed/9199561
PubMed	9259200	http://www.ncbi.nlm.nih.gov/pubmed/9259200
PubMed	9285784	http://www.ncbi.nlm.nih.gov/pubmed/9285784
PubMed	9521593	http://www.ncbi.nlm.nih.gov/pubmed/9521593
PubMed	9889186	http://www.ncbi.nlm.nih.gov/pubmed/9889186
PubMed	9921908	http://www.ncbi.nlm.nih.gov/pubmed/9921908
Reactome	R-HSA-5620916	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5620916
RefSeq	NP_000287	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000287
RefSeq	NP_001009944	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001009944
SMART	SM00013	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00013
SMART	SM00034	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00034
SMART	SM00082	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00082
SMART	SM00089	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00089
SMART	SM00303	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00303
SMART	SM00308	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00308
SMART	SM00321	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00321
SMART	SM00369	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00369
SMR	P98161	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P98161
STRING	9606.ENSP00000262304	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000262304&targetmode=cogs
SUPFAM	SSF49299	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49299
SUPFAM	SSF49723	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49723
SUPFAM	SSF52058	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52058
SUPFAM	SSF56436	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56436
TCDB	1.A.5.1	http://www.tcdb.org/search/result.php?tc=1.A.5.1
TIGRFAMs	TIGR00864	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00864
UCSC	uc002cos	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002cos&org=rat
UniGene	Hs.75813	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.75813
UniProtKB	PKD1_HUMAN	http://www.uniprot.org/uniprot/PKD1_HUMAN
UniProtKB-AC	P98161	http://www.uniprot.org/uniprot/P98161
charge	swissprot:PKD1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:PKD1_HUMAN
eggNOG	ENOG410XTGE	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XTGE
eggNOG	KOG3599	http://eggnogapi.embl.de/nog_data/html/tree/KOG3599
epestfind	swissprot:PKD1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:PKD1_HUMAN
garnier	swissprot:PKD1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:PKD1_HUMAN
helixturnhelix	swissprot:PKD1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:PKD1_HUMAN
hmoment	swissprot:PKD1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:PKD1_HUMAN
iep	swissprot:PKD1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:PKD1_HUMAN
inforesidue	swissprot:PKD1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:PKD1_HUMAN
neXtProt	NX_P98161	http://www.nextprot.org/db/entry/NX_P98161
octanol	swissprot:PKD1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:PKD1_HUMAN
pepcoil	swissprot:PKD1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:PKD1_HUMAN
pepdigest	swissprot:PKD1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:PKD1_HUMAN
pepinfo	swissprot:PKD1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:PKD1_HUMAN
pepnet	swissprot:PKD1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:PKD1_HUMAN
pepstats	swissprot:PKD1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:PKD1_HUMAN
pepwheel	swissprot:PKD1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:PKD1_HUMAN
pepwindow	swissprot:PKD1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:PKD1_HUMAN
sigcleave	swissprot:PKD1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:PKD1_HUMAN
## Database	ID	URL or Descriptions
# AltName	ZNT3_HUMAN	Solute carrier family 30 member 3
# BioGrid	113562	2
# Ensembl	ENST00000233535	ENSP00000233535; ENSG00000115194
# ExpressionAtlas	Q99726	baseline and differential
# FUNCTION	ZNT3_HUMAN	Involved in accumulation of zinc in synaptic vesicles. {ECO 0000250|UniProtKB P97441}. 
# GO_component	GO:0005737	cytoplasm; IDA:BHF-UCL.
# GO_component	GO:0005765	lysosomal membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005768	endosome; TAS:ProtInc.
# GO_component	GO:0005770	late endosome; IDA:BHF-UCL.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0008021	synaptic vesicle; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030672	synaptic vesicle membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0031902	late endosome membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0043005	neuron projection; ISS:UniProtKB.
# GO_function	GO:0015633	zinc-transporting ATPase activity; TAS:ProtInc.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0010043	response to zinc ion; IBA:GO_Central.
# GO_process	GO:0051050	positive regulation of transport; IEA:Ensembl.
# GO_process	GO:0061088	regulation of sequestering of zinc ion; IDA:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.20.1510.10	-; 1.
# Genevisible	Q99726	HS
# HGNC	HGNC:11014	SLC30A3
# INTERACTION	ZNT3_HUMAN	Q58DX5 NAALADL2; NbExp=3; IntAct=EBI-10294651, EBI-10178964; 
# IntAct	Q99726	2
# InterPro	IPR002524	Cation_efflux
# InterPro	IPR027469	Cation_efflux_TMD
# KEGG_Brite	ko02001	Solute carrier family
# MIM	602878	gene
# Organism	ZNT3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11562	PTHR11562
# Pfam	PF01545	Cation_efflux
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-435368	Zinc efflux and compartmentalization by the SLC30 family
# RecName	ZNT3_HUMAN	Zinc transporter 3
# RefSeq	NP_001305878	NM_001318949.1
# RefSeq	NP_001305879	NM_001318950.1
# RefSeq	NP_001305880	NM_001318951.1
# RefSeq	NP_003450	NM_003459.4
# SIMILARITY	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	ZNT3_HUMAN	Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO 0000250|UniProtKB P97441}; Multi- pass membrane protein {ECO 0000255}. Cell junction, synapse, synaptosome {ECO 0000250|UniProtKB P97441}. Late endosome membrane {ECO 0000269|PubMed 17349999}; Multi-pass membrane protein {ECO 0000255}. Lysosome membrane {ECO 0000269|PubMed 17349999}; Multi-pass membrane protein {ECO 0000255}. 
# TCDB	2.A.4.3	the cation diffusion facilitator (cdf) family
# TIGRFAMs	TIGR01297	CDF
# UCSC	uc002rjk	human
# eggNOG	COG1230	LUCA
# eggNOG	KOG1482	Eukaryota
BLAST	swissprot:ZNT3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ZNT3_HUMAN
BioCyc	ZFISH:ENSG00000115194-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000115194-MONOMER
COXPRESdb	7781	http://coxpresdb.jp/data/gene/7781.shtml
CleanEx	HS_SLC30A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC30A3
DOI	10.1016/j.yexcr.2007.02.006	http://dx.doi.org/10.1016/j.yexcr.2007.02.006
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.93.25.14934	http://dx.doi.org/10.1073/pnas.93.25.14934
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC013413	http://www.ebi.ac.uk/ena/data/view/AC013413
EMBL	AK313600	http://www.ebi.ac.uk/ena/data/view/AK313600
EMBL	BC028358	http://www.ebi.ac.uk/ena/data/view/BC028358
EMBL	U76010	http://www.ebi.ac.uk/ena/data/view/U76010
Ensembl	ENST00000233535	http://www.ensembl.org/id/ENST00000233535
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GO_component	GO:0005770	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005770
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0008021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008021
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030672	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030672
GO_component	GO:0031902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031902
GO_component	GO:0043005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043005
GO_function	GO:0015633	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015633
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0010043	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010043
GO_process	GO:0051050	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051050
GO_process	GO:0061088	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061088
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.20.1510.10	http://www.cathdb.info/version/latest/superfamily/1.20.1510.10
GeneCards	SLC30A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC30A3
GeneID	7781	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7781
GeneTree	ENSGT00550000074381	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074381
H-InvDB	HIX0001914	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0001914
HGNC	HGNC:11014	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11014
HOGENOM	HOG000079023	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000079023&db=HOGENOM6
HOVERGEN	HBG003345	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003345&db=HOVERGEN
HPA	HPA060505	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA060505
HPA	HPA067637	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA067637
InParanoid	Q99726	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q99726
IntAct	Q99726	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q99726*
InterPro	IPR002524	http://www.ebi.ac.uk/interpro/entry/IPR002524
InterPro	IPR027469	http://www.ebi.ac.uk/interpro/entry/IPR027469
Jabion	7781	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7781
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:7781	http://www.genome.jp/dbget-bin/www_bget?hsa:7781
KEGG_Orthology	KO:K14690	http://www.genome.jp/dbget-bin/www_bget?KO:K14690
MIM	602878	http://www.ncbi.nlm.nih.gov/omim/602878
OMA	AQCLRCR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AQCLRCR
OrthoDB	EOG091G07UN	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07UN
PANTHER	PTHR11562	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11562
PSORT	swissprot:ZNT3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ZNT3_HUMAN
PSORT-B	swissprot:ZNT3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ZNT3_HUMAN
PSORT2	swissprot:ZNT3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ZNT3_HUMAN
Pfam	PF01545	http://pfam.xfam.org/family/PF01545
PharmGKB	PA35884	http://www.pharmgkb.org/do/serve?objId=PA35884&objCls=Gene
Phobius	swissprot:ZNT3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ZNT3_HUMAN
PhylomeDB	Q99726	http://phylomedb.org/?seqid=Q99726
ProteinModelPortal	Q99726	http://www.proteinmodelportal.org/query/uniprot/Q99726
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	17349999	http://www.ncbi.nlm.nih.gov/pubmed/17349999
PubMed	8962159	http://www.ncbi.nlm.nih.gov/pubmed/8962159
Reactome	R-HSA-435368	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-435368
RefSeq	NP_001305878	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001305878
RefSeq	NP_001305879	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001305879
RefSeq	NP_001305880	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001305880
RefSeq	NP_003450	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003450
STRING	9606.ENSP00000233535	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000233535&targetmode=cogs
TCDB	2.A.4.3	http://www.tcdb.org/search/result.php?tc=2.A.4.3
TIGRFAMs	TIGR01297	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01297
UCSC	uc002rjk	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002rjk&org=rat
UniGene	Hs.467981	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.467981
UniProtKB	ZNT3_HUMAN	http://www.uniprot.org/uniprot/ZNT3_HUMAN
UniProtKB-AC	Q99726	http://www.uniprot.org/uniprot/Q99726
charge	swissprot:ZNT3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ZNT3_HUMAN
eggNOG	COG1230	http://eggnogapi.embl.de/nog_data/html/tree/COG1230
eggNOG	KOG1482	http://eggnogapi.embl.de/nog_data/html/tree/KOG1482
epestfind	swissprot:ZNT3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ZNT3_HUMAN
garnier	swissprot:ZNT3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ZNT3_HUMAN
helixturnhelix	swissprot:ZNT3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZNT3_HUMAN
hmoment	swissprot:ZNT3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ZNT3_HUMAN
iep	swissprot:ZNT3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ZNT3_HUMAN
inforesidue	swissprot:ZNT3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ZNT3_HUMAN
neXtProt	NX_Q99726	http://www.nextprot.org/db/entry/NX_Q99726
octanol	swissprot:ZNT3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ZNT3_HUMAN
pepcoil	swissprot:ZNT3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ZNT3_HUMAN
pepdigest	swissprot:ZNT3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ZNT3_HUMAN
pepinfo	swissprot:ZNT3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ZNT3_HUMAN
pepnet	swissprot:ZNT3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ZNT3_HUMAN
pepstats	swissprot:ZNT3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ZNT3_HUMAN
pepwheel	swissprot:ZNT3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ZNT3_HUMAN
pepwindow	swissprot:ZNT3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ZNT3_HUMAN
sigcleave	swissprot:ZNT3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ZNT3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SC5A9_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q2M3M2-1; Sequence=Displayed; Name=2; IsoId=Q2M3M2-2; Sequence=VSP_044577; Note=No experimental confirmation available.; Name=3; IsoId=Q2M3M2-3; Sequence=VSP_057168; Note=No experimental confirmation available.; 
# AltName	SC5A9_HUMAN	Solute carrier family 5 member 9
# CCDS	CCDS30709	-. [Q2M3M2-1]
# CCDS	CCDS44136	-. [Q2M3M2-2]
# Ensembl	ENST00000236495	ENSP00000236495; ENSG00000117834. [Q2M3M2-2]
# Ensembl	ENST00000438567	ENSP00000401730; ENSG00000117834. [Q2M3M2-1]
# Ensembl	ENST00000533824	ENSP00000431900; ENSG00000117834. [Q2M3M2-3]
# ExpressionAtlas	Q2M3M2	baseline and differential
# FUNCTION	SC5A9_HUMAN	Involved in sodium-dependent transport of D-mannose, D- glucose and D-fructose. {ECO 0000269|PubMed 15607332}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0015293	symporter activity; IBA:GO_Central.
# GO_function	SC5A9_HUMAN	GO 0005362 low-affinity glucose sodium symporter activity; TAS Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# Genevisible	Q2M3M2	HS
# HGNC	HGNC:22146	SLC5A9
# InterPro	IPR001734	Na/solute_symporter
# InterPro	IPR018212	Na/solute_symporter_CS
# KEGG_Brite	ko02001	Solute carrier family
# Organism	SC5A9_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11819	PTHR11819; 3
# PROSITE	PS00456	NA_SOLUT_SYMP_1
# PROSITE	PS50283	NA_SOLUT_SYMP_3
# Pfam	PF00474	SSF
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-189200	Hexose transport
# Reactome	R-HSA-428808	Na+-dependent glucose transporters
# Reactome	R-HSA-429593	Inositol transporters
# RecName	SC5A9_HUMAN	Sodium/glucose cotransporter 4
# RefSeq	NP_001011547	NM_001011547.2. [Q2M3M2-1]
# RefSeq	NP_001128653	NM_001135181.1. [Q2M3M2-2]
# SEQUENCE CAUTION	Sequence=CAI18915.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	SC5A9_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	2.A.21.3.17:the solute	sodium symporter (sss) family
# TIGRFAMs	TIGR00813	sss
# TISSUE SPECIFICITY	Expressed in the small intestine, kidney and liver. {ECO:0000269|PubMed	15607332}. 
# UCSC	uc001crn	human. [Q2M3M2-1]
# eggNOG	COG4146	LUCA
# eggNOG	ENOG410IP49	Eukaryota
BLAST	swissprot:SC5A9_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SC5A9_HUMAN
COXPRESdb	200010	http://coxpresdb.jp/data/gene/200010.shtml
CleanEx	HS_SLC5A9	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC5A9
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.lfs.2004.10.016	http://dx.doi.org/10.1016/j.lfs.2004.10.016
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AK131200	http://www.ebi.ac.uk/ena/data/view/AK131200
EMBL	AL109659	http://www.ebi.ac.uk/ena/data/view/AL109659
EMBL	BC104857	http://www.ebi.ac.uk/ena/data/view/BC104857
EMBL	BC104863	http://www.ebi.ac.uk/ena/data/view/BC104863
EMBL	BC143570	http://www.ebi.ac.uk/ena/data/view/BC143570
EMBL	BC143572	http://www.ebi.ac.uk/ena/data/view/BC143572
EMBL	CH471059	http://www.ebi.ac.uk/ena/data/view/CH471059
Ensembl	ENST00000236495	http://www.ensembl.org/id/ENST00000236495
Ensembl	ENST00000438567	http://www.ensembl.org/id/ENST00000438567
Ensembl	ENST00000533824	http://www.ensembl.org/id/ENST00000533824
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005362	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005362
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GeneCards	SLC5A9	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC5A9
GeneID	200010	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=200010
GeneTree	ENSGT00760000118955	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118955
H-InvDB	HIX0023625	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0023625
H-InvDB	HIX0029229	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0029229
HGNC	HGNC:22146	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:22146
HOGENOM	HOG000025422	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000025422&db=HOGENOM6
HOVERGEN	HBG052859	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052859&db=HOVERGEN
HPA	CAB013090	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB013090
InParanoid	Q2M3M2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q2M3M2
InterPro	IPR001734	http://www.ebi.ac.uk/interpro/entry/IPR001734
InterPro	IPR018212	http://www.ebi.ac.uk/interpro/entry/IPR018212
Jabion	200010	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=200010
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:200010	http://www.genome.jp/dbget-bin/www_bget?hsa:200010
KEGG_Orthology	KO:K14389	http://www.genome.jp/dbget-bin/www_bget?KO:K14389
OMA	QRIQIYM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QRIQIYM
OrthoDB	EOG091G077U	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G077U
PANTHER	PTHR11819	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11819
PROSITE	PS00456	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00456
PROSITE	PS50283	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50283
PSORT	swissprot:SC5A9_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SC5A9_HUMAN
PSORT-B	swissprot:SC5A9_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SC5A9_HUMAN
PSORT2	swissprot:SC5A9_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SC5A9_HUMAN
Pfam	PF00474	http://pfam.xfam.org/family/PF00474
PharmGKB	PA134949681	http://www.pharmgkb.org/do/serve?objId=PA134949681&objCls=Gene
Phobius	swissprot:SC5A9_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SC5A9_HUMAN
PhylomeDB	Q2M3M2	http://phylomedb.org/?seqid=Q2M3M2
ProteinModelPortal	Q2M3M2	http://www.proteinmodelportal.org/query/uniprot/Q2M3M2
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15607332	http://www.ncbi.nlm.nih.gov/pubmed/15607332
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
Reactome	R-HSA-189200	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-189200
Reactome	R-HSA-428808	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428808
Reactome	R-HSA-429593	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-429593
RefSeq	NP_001011547	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001011547
RefSeq	NP_001128653	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001128653
STRING	9606.ENSP00000236495	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000236495&targetmode=cogs
TCDB	2.A.21.3.17	http://www.tcdb.org/search/result.php?tc=2.A.21.3.17
TIGRFAMs	TIGR00813	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00813
UCSC	uc001crn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001crn&org=rat
UniGene	Hs.37890	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.37890
UniProtKB	SC5A9_HUMAN	http://www.uniprot.org/uniprot/SC5A9_HUMAN
UniProtKB-AC	Q2M3M2	http://www.uniprot.org/uniprot/Q2M3M2
charge	swissprot:SC5A9_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SC5A9_HUMAN
eggNOG	COG4146	http://eggnogapi.embl.de/nog_data/html/tree/COG4146
eggNOG	ENOG410IP49	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IP49
epestfind	swissprot:SC5A9_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SC5A9_HUMAN
garnier	swissprot:SC5A9_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SC5A9_HUMAN
helixturnhelix	swissprot:SC5A9_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SC5A9_HUMAN
hmoment	swissprot:SC5A9_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SC5A9_HUMAN
iep	swissprot:SC5A9_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SC5A9_HUMAN
inforesidue	swissprot:SC5A9_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SC5A9_HUMAN
neXtProt	NX_Q2M3M2	http://www.nextprot.org/db/entry/NX_Q2M3M2
octanol	swissprot:SC5A9_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SC5A9_HUMAN
pepcoil	swissprot:SC5A9_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SC5A9_HUMAN
pepdigest	swissprot:SC5A9_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SC5A9_HUMAN
pepinfo	swissprot:SC5A9_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SC5A9_HUMAN
pepnet	swissprot:SC5A9_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SC5A9_HUMAN
pepstats	swissprot:SC5A9_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SC5A9_HUMAN
pepwheel	swissprot:SC5A9_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SC5A9_HUMAN
pepwindow	swissprot:SC5A9_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SC5A9_HUMAN
sigcleave	swissprot:SC5A9_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SC5A9_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	LASP1_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q14847-1; Sequence=Displayed; Name=2; IsoId=Q14847-2; Sequence=VSP_016554; Note=No experimental confirmation available.; Name=3; IsoId=Q14847-3; Sequence=VSP_054611; Note=No experimental confirmation available.; 
# AltName	LASP1_HUMAN	Metastatic lymph node gene 50 protein
# BioGrid	110120	64
# CCDS	CCDS11331	-. [Q14847-1]
# CCDS	CCDS62164	-. [Q14847-3]
# ChiTaRS	LASP1	human
# Ensembl	ENST00000318008	ENSP00000325240; ENSG00000002834. [Q14847-1]
# Ensembl	ENST00000433206	ENSP00000401048; ENSG00000002834. [Q14847-3]
# Ensembl	ENST00000435347	ENSP00000392853; ENSG00000002834. [Q14847-1]
# ExpressionAtlas	Q14847	baseline and differential
# FUNCTION	LASP1_HUMAN	Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO 0000250}. 
# GO_component	GO:0005737	cytoplasm; IDA:BHF-UCL.
# GO_component	GO:0005913	cell-cell adherens junction; IDA:BHF-UCL.
# GO_component	GO:0005925	focal adhesion; IDA:UniProtKB.
# GO_component	GO:0030864	cortical actin cytoskeleton; ISS:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005070	SH3/SH2 adaptor activity; TAS:ProtInc.
# GO_function	GO:0008270	zinc ion binding; IEA:InterPro.
# GO_function	GO:0015075	ion transmembrane transporter activity; ISS:UniProtKB.
# GO_function	GO:0098641	cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
# GO_process	GO:0006811	ion transport; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005856	cytoskeleton
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0030674	protein binding, bridging
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# Gene3D	2.10.110.10	-; 1.
# Genevisible	Q14847	HS
# HGNC	HGNC:6513	LASP1
# INTERACTION	LASP1_HUMAN	D3DTR7 ARHGEF15; NbExp=3; IntAct=EBI-742828, EBI-10176602; P51116 FXR2; NbExp=3; IntAct=EBI-742828, EBI-740459; Q08379 GOLGA2; NbExp=3; IntAct=EBI-742828, EBI-618309; Q9BYR5 KRTAP4-2; NbExp=3; IntAct=EBI-742828, EBI-10172511; Q93052 LPP; NbExp=3; IntAct=EBI-742828, EBI-718388; Q9BRK4 LZTS2; NbExp=3; IntAct=EBI-742828, EBI-741037; Q99750 MDFI; NbExp=3; IntAct=EBI-742828, EBI-724076; P25788 PSMA3; NbExp=3; IntAct=EBI-742828, EBI-348380; Q93062-3 RBPMS; NbExp=4; IntAct=EBI-9088686, EBI-740343; Q04864 REL; NbExp=3; IntAct=EBI-742828, EBI-307352; Q9BQY4 RHOXF2; NbExp=3; IntAct=EBI-742828, EBI-372094; Q9UH03 SEPT3; NbExp=3; IntAct=EBI-742828, EBI-727037; Q9NP31 SH2D2A; NbExp=2; IntAct=EBI-742828, EBI-490630; O43597 SPRY2; NbExp=3; IntAct=EBI-742828, EBI-742487; P15884 TCF4; NbExp=3; IntAct=EBI-742828, EBI-533224; Q9NVV9 THAP1; NbExp=3; IntAct=EBI-742828, EBI-741515; Q9UDY2 TJP2; NbExp=9; IntAct=EBI-742828, EBI-1042602; P14373 TRIM27; NbExp=3; IntAct=EBI-742828, EBI-719493; Q15645 TRIP13; NbExp=7; IntAct=EBI-742828, EBI-358993; Q96C00 ZBTB9; NbExp=3; IntAct=EBI-742828, EBI-395708; Q96GY0 ZC2HC1A; NbExp=3; IntAct=EBI-742828, EBI-5458880; Q8IUH5 ZDHHC17; NbExp=3; IntAct=EBI-9088686, EBI-524753; Q15942 ZYX; NbExp=5; IntAct=EBI-742828, EBI-444225; 
# IntAct	Q14847	50
# InterPro	IPR000900	Nebulin_repeat
# InterPro	IPR001452	SH3_domain
# InterPro	IPR001781	Znf_LIM
# MIM	602920	gene
# Organism	LASP1_HUMAN	Homo sapiens (Human)
# PDB	3I35	X-ray; 1.40 A; A=202-261
# PIR	S68234	S68234
# PRINTS	PR00452	SH3DOMAIN
# PROSITE	PS00478	LIM_DOMAIN_1
# PROSITE	PS50002	SH3
# PROSITE	PS50023	LIM_DOMAIN_2
# PROSITE	PS51216	NEBULIN; 2
# Pfam	PF00412	LIM
# Pfam	PF00880	Nebulin; 2
# Pfam	PF14604	SH3_9
# Proteomes	UP000005640	Chromosome 17
# RecName	LASP1_HUMAN	LIM and SH3 domain protein 1
# RefSeq	NP_001258537	NM_001271608.1. [Q14847-3]
# RefSeq	NP_006139	NM_006148.3. [Q14847-1]
# SIMILARITY	Contains 1 LIM zinc-binding domain. {ECO:0000255|PROSITE-ProRule	PRU00125}. 
# SIMILARITY	Contains 1 SH3 domain. {ECO:0000255|PROSITE- ProRule	PRU00192}. 
# SIMILARITY	Contains 2 nebulin repeats. {ECO:0000255|PROSITE- ProRule	PRU00563}. 
# SMART	SM00132	LIM
# SMART	SM00227	NEBU; 2
# SMART	SM00326	SH3
# SUBCELLULAR LOCATION	LASP1_HUMAN	Cytoplasm, cell cortex {ECO 0000250}. Cytoplasm, cytoskeleton {ECO 0000250}. Note=Associated with the F- actin rich cortical cytoskeleton. {ECO 0000250}. 
# SUBUNIT	Interacts with F-actin (By similarity). Interacts with ANKRD54 (By similarity). Interacts with KBTBD10. {ECO:0000250, ECO	0000269|PubMed:19726686}. 
# SUPFAM	SSF50044	SSF50044
# UCSC	uc002hra	human. [Q14847-1]
# WEB RESOURCE	LASP1_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/Lasp1ID203.html";
# eggNOG	ENOG4111GQ8	LUCA
# eggNOG	KOG1702	Eukaryota
BLAST	swissprot:LASP1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:LASP1_HUMAN
BioCyc	ZFISH:ENSG00000002834-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000002834-MONOMER
COXPRESdb	3927	http://coxpresdb.jp/data/gene/3927.shtml
CleanEx	HS_LASP1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_LASP1
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/geno.1995.1163	http://dx.doi.org/10.1006/geno.1995.1163
DOI	10.1016/0014-5793(95)01040-L	http://dx.doi.org/10.1016/0014-5793(95)01040-L
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr070152u	http://dx.doi.org/10.1021/pr070152u
DOI	10.1021/pr0704130	http://dx.doi.org/10.1021/pr0704130
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1038/nbt810	http://dx.doi.org/10.1038/nbt810
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/jbc.M109.023259	http://dx.doi.org/10.1074/jbc.M109.023259
DOI	10.1074/mcp.O113.027870	http://dx.doi.org/10.1074/mcp.O113.027870
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AC006441	http://www.ebi.ac.uk/ena/data/view/AC006441
EMBL	AC110749	http://www.ebi.ac.uk/ena/data/view/AC110749
EMBL	AK294704	http://www.ebi.ac.uk/ena/data/view/AK294704
EMBL	BC007560	http://www.ebi.ac.uk/ena/data/view/BC007560
EMBL	BC012460	http://www.ebi.ac.uk/ena/data/view/BC012460
EMBL	X82456	http://www.ebi.ac.uk/ena/data/view/X82456
Ensembl	ENST00000318008	http://www.ensembl.org/id/ENST00000318008
Ensembl	ENST00000433206	http://www.ensembl.org/id/ENST00000433206
Ensembl	ENST00000435347	http://www.ensembl.org/id/ENST00000435347
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005913
GO_component	GO:0005925	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005925
GO_component	GO:0030864	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030864
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005070	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005070
GO_function	GO:0008270	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270
GO_function	GO:0015075	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015075
GO_function	GO:0098641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098641
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0030674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030674
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
Gene3D	2.10.110.10	http://www.cathdb.info/version/latest/superfamily/2.10.110.10
GeneCards	LASP1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=LASP1
GeneID	3927	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3927
GeneTree	ENSGT00530000062924	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062924
HGNC	HGNC:6513	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6513
HOGENOM	HOG000006616	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006616&db=HOGENOM6
HOVERGEN	HBG054636	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054636&db=HOVERGEN
HPA	CAB022049	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB022049
HPA	HPA012072	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA012072
InParanoid	Q14847	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q14847
IntAct	Q14847	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q14847*
InterPro	IPR000900	http://www.ebi.ac.uk/interpro/entry/IPR000900
InterPro	IPR001452	http://www.ebi.ac.uk/interpro/entry/IPR001452
InterPro	IPR001781	http://www.ebi.ac.uk/interpro/entry/IPR001781
Jabion	3927	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3927
KEGG_Gene	hsa:3927	http://www.genome.jp/dbget-bin/www_bget?hsa:3927
MIM	602920	http://www.ncbi.nlm.nih.gov/omim/602920
MINT	MINT-5001286	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5001286
OMA	YGYKEPA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YGYKEPA
OrthoDB	EOG091G0U2O	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0U2O
PDB	3I35	http://www.ebi.ac.uk/pdbe-srv/view/entry/3I35
PDBsum	3I35	http://www.ebi.ac.uk/pdbsum/3I35
PRINTS	PR00452	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00452
PROSITE	PS00478	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00478
PROSITE	PS50002	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50002
PROSITE	PS50023	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50023
PROSITE	PS51216	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51216
PSORT	swissprot:LASP1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:LASP1_HUMAN
PSORT-B	swissprot:LASP1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:LASP1_HUMAN
PSORT2	swissprot:LASP1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:LASP1_HUMAN
Pfam	PF00412	http://pfam.xfam.org/family/PF00412
Pfam	PF00880	http://pfam.xfam.org/family/PF00880
Pfam	PF14604	http://pfam.xfam.org/family/PF14604
PharmGKB	PA30298	http://www.pharmgkb.org/do/serve?objId=PA30298&objCls=Gene
Phobius	swissprot:LASP1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:LASP1_HUMAN
PhylomeDB	Q14847	http://phylomedb.org/?seqid=Q14847
ProteinModelPortal	Q14847	http://www.proteinmodelportal.org/query/uniprot/Q14847
PubMed	12665801	http://www.ncbi.nlm.nih.gov/pubmed/12665801
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	17924679	http://www.ncbi.nlm.nih.gov/pubmed/17924679
PubMed	18088087	http://www.ncbi.nlm.nih.gov/pubmed/18088087
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	19726686	http://www.ncbi.nlm.nih.gov/pubmed/19726686
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24129315	http://www.ncbi.nlm.nih.gov/pubmed/24129315
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	7490069	http://www.ncbi.nlm.nih.gov/pubmed/7490069
PubMed	7589475	http://www.ncbi.nlm.nih.gov/pubmed/7589475
RefSeq	NP_001258537	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001258537
RefSeq	NP_006139	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006139
SMART	SM00132	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00132
SMART	SM00227	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00227
SMART	SM00326	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00326
SMR	Q14847	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q14847
STRING	9606.ENSP00000325240	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000325240&targetmode=cogs
SUPFAM	SSF50044	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50044
SWISS-2DPAGE	Q14847	http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=Q14847
UCSC	uc002hra	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002hra&org=rat
UniGene	Hs.741156	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.741156
UniProtKB	LASP1_HUMAN	http://www.uniprot.org/uniprot/LASP1_HUMAN
UniProtKB-AC	Q14847	http://www.uniprot.org/uniprot/Q14847
charge	swissprot:LASP1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:LASP1_HUMAN
eggNOG	ENOG4111GQ8	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111GQ8
eggNOG	KOG1702	http://eggnogapi.embl.de/nog_data/html/tree/KOG1702
epestfind	swissprot:LASP1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:LASP1_HUMAN
garnier	swissprot:LASP1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:LASP1_HUMAN
helixturnhelix	swissprot:LASP1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:LASP1_HUMAN
hmoment	swissprot:LASP1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:LASP1_HUMAN
iep	swissprot:LASP1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:LASP1_HUMAN
inforesidue	swissprot:LASP1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:LASP1_HUMAN
neXtProt	NX_Q14847	http://www.nextprot.org/db/entry/NX_Q14847
octanol	swissprot:LASP1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:LASP1_HUMAN
pepcoil	swissprot:LASP1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:LASP1_HUMAN
pepdigest	swissprot:LASP1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:LASP1_HUMAN
pepinfo	swissprot:LASP1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:LASP1_HUMAN
pepnet	swissprot:LASP1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:LASP1_HUMAN
pepstats	swissprot:LASP1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:LASP1_HUMAN
pepwheel	swissprot:LASP1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:LASP1_HUMAN
pepwindow	swissprot:LASP1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:LASP1_HUMAN
sigcleave	swissprot:LASP1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:LASP1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNC1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P48547-1; Sequence=Displayed; Name=2; IsoId=P48547-2; Sequence=VSP_055129; Note=No experimental confirmation available. Gene prediction based on EST data.; 
# AltName	KCNC1_HUMAN	NGK2
# AltName	KCNC1_HUMAN	Voltage-gated potassium channel subunit Kv3.1
# AltName	KCNC1_HUMAN	Voltage-gated potassium channel subunit Kv4
# BioGrid	109948	8
# CCDS	CCDS44547	-. [P48547-2]
# CCDS	CCDS7827	-. [P48547-1]
# DISEASE	KCNC1_HUMAN	Epilepsy, progressive myoclonic 7 (EPM7) [MIM 616187]  A neurologic disorder characterized by progressive myoclonic epilepsy, manifesting in the first or second decades of life. Cognitive function may decline in some patients. Myoclonus is a brief, involuntary twitching of a muscle or a group of muscles. {ECO 0000269|PubMed 25401298}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	KCNC1_HUMAN	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. {ECO 0000305}. 
# DOMAIN	KCNC1_HUMAN	The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. {ECO 0000305}. 
# DrugBank	DB06637	Dalfampridine
# Ensembl	ENST00000265969	ENSP00000265969; ENSG00000129159. [P48547-2]
# Ensembl	ENST00000379472	ENSP00000368785; ENSG00000129159. [P48547-1]
# FUNCTION	KCNC1_HUMAN	Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient (PubMed 25401298). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons. {ECO 0000250|UniProtKB P25122, ECO 0000269|PubMed 25401298}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IDA:UniProtKB.
# GO_component	GO:0009986	cell surface; IEA:Ensembl.
# GO_component	GO:0030425	dendrite; IEA:Ensembl.
# GO_component	GO:0032589	neuron projection membrane; IEA:Ensembl.
# GO_component	GO:0032809	neuronal cell body membrane; ISS:UniProtKB.
# GO_function	GO:0005249	voltage-gated potassium channel activity; TAS:ProtInc.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; ISS:UniProtKB.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0009636	response to toxic substance; IEA:Ensembl.
# GO_process	GO:0009642	response to light intensity; IEA:Ensembl.
# GO_process	GO:0010996	response to auditory stimulus; IEA:Ensembl.
# GO_process	GO:0014075	response to amine; IEA:Ensembl.
# GO_process	GO:0021549	cerebellum development; IEA:Ensembl.
# GO_process	GO:0021759	globus pallidus development; IEA:Ensembl.
# GO_process	GO:0035690	cellular response to drug; IEA:Ensembl.
# GO_process	GO:0035864	response to potassium ion; IEA:Ensembl.
# GO_process	GO:0051260	protein homooligomerization; IEA:InterPro.
# GO_process	GO:0051262	protein tetramerization; IDA:UniProtKB.
# GO_process	GO:0071774	response to fibroblast growth factor; IEA:Ensembl.
# GO_process	GO:0071805	potassium ion transmembrane transport; ISS:UniProtKB.
# GO_process	GO:1901381	positive regulation of potassium ion transmembrane transport; IEA:Ensembl.
# GO_process	GO:1990089	response to nerve growth factor; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.350	-; 1.
# Genevisible	P48547	HS
# HGNC	HGNC:6233	KCNC1
# InterPro	IPR000210	BTB/POZ_dom
# InterPro	IPR003131	T1-type_BTB
# InterPro	IPR003968	K_chnl_volt-dep_Kv
# InterPro	IPR003974	K_chnl_volt-dep_Kv3
# InterPro	IPR005403	K_chnl_volt-dep_Kv3.1
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR011333	SKP1/BTB/POZ
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko04040	Ion channels
# MIM	176258	gene
# MIM	616187	phenotype
# Organism	KCNC1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11537	PTHR11537; 2
# PIR	A46020	A46020
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01491	KVCHANNEL
# PRINTS	PR01498	SHAWCHANNEL
# PRINTS	PR01581	KV31CHANNEL
# PTM	KCNC1_HUMAN	N-glycosylated; contains sialylated glycans. {ECO 0000250|UniProtKB P25122}. 
# Pfam	PF00520	Ion_trans
# Pfam	PF02214	BTB_2
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# RecName	KCNC1_HUMAN	Potassium voltage-gated channel subfamily C member 1
# RefSeq	NP_001106212	NM_001112741.1. [P48547-2]
# RefSeq	NP_004967	NM_004976.4. [P48547-1]
# SIMILARITY	Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.1/KCNC1 sub-subfamily. {ECO	0000305}.
# SMART	SM00225	BTB
# SUBCELLULAR LOCATION	KCNC1_HUMAN	Cell membrane {ECO 0000269|PubMed 25401298}; Multi-pass membrane protein {ECO 0000255}. 
# SUBUNIT	KCNC1_HUMAN	Heteromultimer with KCNG3, KCNG4 and KCNV2 (By similarity). Heteromultimer with KCNC2 (By similarity). Heterotetramer with KCNC3 (PubMed 23734863). Interacts with the ancillary subunits KCNE1 and KCNE2; the interaction modulates channel activity (By similarity). {ECO 0000250, ECO 0000250|UniProtKB P25122, ECO 0000269|PubMed 23734863}. 
# SUPFAM	SSF54695	SSF54695
# UCSC	uc001mnk	human. [P48547-1]
# eggNOG	COG1226	LUCA
# eggNOG	KOG3713	Eukaryota
BLAST	swissprot:KCNC1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNC1_HUMAN
BioCyc	ZFISH:ENSG00000129159-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000129159-MONOMER
COXPRESdb	3746	http://coxpresdb.jp/data/gene/3746.shtml
CleanEx	HS_KCNC1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNC1
DOI	10.1006/geno.1993.1075	http://dx.doi.org/10.1006/geno.1993.1075
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1038/ng.3144	http://dx.doi.org/10.1038/ng.3144
DOI	10.1042/BJ20130034	http://dx.doi.org/10.1042/BJ20130034
DrugBank	DB06637	http://www.drugbank.ca/drugs/DB06637
EMBL	AC124056	http://www.ebi.ac.uk/ena/data/view/AC124056
EMBL	AC124078	http://www.ebi.ac.uk/ena/data/view/AC124078
EMBL	AC124301	http://www.ebi.ac.uk/ena/data/view/AC124301
EMBL	CH471064	http://www.ebi.ac.uk/ena/data/view/CH471064
EMBL	M96747	http://www.ebi.ac.uk/ena/data/view/M96747
EMBL	S56770	http://www.ebi.ac.uk/ena/data/view/S56770
Ensembl	ENST00000265969	http://www.ensembl.org/id/ENST00000265969
Ensembl	ENST00000379472	http://www.ensembl.org/id/ENST00000379472
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0032589	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032589
GO_component	GO:0032809	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032809
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0009636	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009636
GO_process	GO:0009642	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009642
GO_process	GO:0010996	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010996
GO_process	GO:0014075	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014075
GO_process	GO:0021549	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021549
GO_process	GO:0021759	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021759
GO_process	GO:0035690	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035690
GO_process	GO:0035864	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035864
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:0051262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051262
GO_process	GO:0071774	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071774
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GO_process	GO:1901381	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901381
GO_process	GO:1990089	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990089
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	KCNC1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNC1
GeneID	3746	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3746
GeneTree	ENSGT00760000118846	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118846
HGNC	HGNC:6233	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6233
HOGENOM	HOG000231012	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231012&db=HOGENOM6
HOVERGEN	HBG105862	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG105862&db=HOVERGEN
HPA	HPA047634	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA047634
InParanoid	P48547	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P48547
InterPro	IPR000210	http://www.ebi.ac.uk/interpro/entry/IPR000210
InterPro	IPR003131	http://www.ebi.ac.uk/interpro/entry/IPR003131
InterPro	IPR003968	http://www.ebi.ac.uk/interpro/entry/IPR003968
InterPro	IPR003974	http://www.ebi.ac.uk/interpro/entry/IPR003974
InterPro	IPR005403	http://www.ebi.ac.uk/interpro/entry/IPR005403
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR011333	http://www.ebi.ac.uk/interpro/entry/IPR011333
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	3746	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3746
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3746	http://www.genome.jp/dbget-bin/www_bget?hsa:3746
KEGG_Orthology	KO:K04887	http://www.genome.jp/dbget-bin/www_bget?KO:K04887
MIM	176258	http://www.ncbi.nlm.nih.gov/omim/176258
MIM	616187	http://www.ncbi.nlm.nih.gov/omim/616187
OMA	MGQGDDS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MGQGDDS
OrthoDB	EOG091G0EJL	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0EJL
PANTHER	PTHR11537	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01491	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01491
PRINTS	PR01498	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01498
PRINTS	PR01581	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01581
PSORT	swissprot:KCNC1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNC1_HUMAN
PSORT-B	swissprot:KCNC1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNC1_HUMAN
PSORT2	swissprot:KCNC1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNC1_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF02214	http://pfam.xfam.org/family/PF02214
PharmGKB	PA30026	http://www.pharmgkb.org/do/serve?objId=PA30026&objCls=Gene
Phobius	swissprot:KCNC1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNC1_HUMAN
PhylomeDB	P48547	http://phylomedb.org/?seqid=P48547
ProteinModelPortal	P48547	http://www.proteinmodelportal.org/query/uniprot/P48547
PubMed	1400413	http://www.ncbi.nlm.nih.gov/pubmed/1400413
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	23734863	http://www.ncbi.nlm.nih.gov/pubmed/23734863
PubMed	25401298	http://www.ncbi.nlm.nih.gov/pubmed/25401298
PubMed	8449507	http://www.ncbi.nlm.nih.gov/pubmed/8449507
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
RefSeq	NP_001106212	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001106212
RefSeq	NP_004967	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004967
SMART	SM00225	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225
SMR	P48547	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P48547
STRING	9606.ENSP00000265969	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000265969&targetmode=cogs
SUPFAM	SSF54695	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54695
UCSC	uc001mnk	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001mnk&org=rat
UniGene	Hs.552896	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.552896
UniProtKB	KCNC1_HUMAN	http://www.uniprot.org/uniprot/KCNC1_HUMAN
UniProtKB-AC	P48547	http://www.uniprot.org/uniprot/P48547
charge	swissprot:KCNC1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNC1_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG3713	http://eggnogapi.embl.de/nog_data/html/tree/KOG3713
epestfind	swissprot:KCNC1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNC1_HUMAN
garnier	swissprot:KCNC1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNC1_HUMAN
helixturnhelix	swissprot:KCNC1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNC1_HUMAN
hmoment	swissprot:KCNC1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNC1_HUMAN
iep	swissprot:KCNC1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNC1_HUMAN
inforesidue	swissprot:KCNC1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNC1_HUMAN
neXtProt	NX_P48547	http://www.nextprot.org/db/entry/NX_P48547
octanol	swissprot:KCNC1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNC1_HUMAN
pepcoil	swissprot:KCNC1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNC1_HUMAN
pepdigest	swissprot:KCNC1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNC1_HUMAN
pepinfo	swissprot:KCNC1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNC1_HUMAN
pepnet	swissprot:KCNC1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNC1_HUMAN
pepstats	swissprot:KCNC1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNC1_HUMAN
pepwheel	swissprot:KCNC1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNC1_HUMAN
pepwindow	swissprot:KCNC1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNC1_HUMAN
sigcleave	swissprot:KCNC1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNC1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	LAT4_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8N370-1; Sequence=Displayed; Name=2; IsoId=Q8N370-2; Sequence=VSP_028665, VSP_028666; Name=3; IsoId=Q8N370-3; Sequence=VSP_028664; Name=4; IsoId=Q8N370-4; Sequence=VSP_055373, VSP_055374; Note=No experimental confirmation available.; 
# AltName	LAT4_HUMAN	L-type amino acid transporter 4
# AltName	LAT4_HUMAN	Solute carrier family 43 member 2
# BioGrid	125901	3
# CCDS	CCDS11006	-. [Q8N370-1]
# CCDS	CCDS67107	-. [Q8N370-4]
# CCDS	CCDS67108	-. [Q8N370-3]
# CDD	cd06174	MFS
# ChiTaRS	SLC43A2	human
# Ensembl	ENST00000301335	ENSP00000301335; ENSG00000167703. [Q8N370-1]
# Ensembl	ENST00000382147	ENSP00000371582; ENSG00000278550. [Q8N370-4]
# Ensembl	ENST00000412517	ENSP00000408284; ENSG00000167703. [Q8N370-4]
# Ensembl	ENST00000571650	ENSP00000461382; ENSG00000167703. [Q8N370-3]
# Ensembl	ENST00000612931	ENSP00000483848; ENSG00000278550. [Q8N370-3]
# Ensembl	ENST00000613070	ENSP00000484291; ENSG00000278550. [Q8N370-3]
# Ensembl	ENST00000634102	ENSP00000488355; ENSG00000278550. [Q8N370-1]
# ExpressionAtlas	Q8N370	baseline and differential
# FUNCTION	LAT4_HUMAN	Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids. {ECO 0000269|PubMed 15659399}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015175	neutral amino acid transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015179	L-amino acid transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0006865	amino acid transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q8N370	HS
# HGNC	HGNC:23087	SLC43A2
# IntAct	Q8N370	3
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# InterPro	IPR027201	LAT4
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	610791	gene
# Organism	LAT4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR20766:SF2	PTHR20766:SF2
# PTM	LAT4_HUMAN	Glycosylated. {ECO 0000250}. 
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-352230	Amino acid transport across the plasma membrane
# RecName	LAT4_HUMAN	Large neutral amino acids transporter small subunit 4
# RefSeq	NP_001271427	NM_001284498.1. [Q8N370-3]
# RefSeq	NP_001271428	NM_001284499.1. [Q8N370-4]
# RefSeq	NP_001308293	NM_001321364.1. [Q8N370-3]
# RefSeq	NP_001308294	NM_001321365.1. [Q8N370-3]
# RefSeq	NP_689559	NM_152346.2. [Q8N370-1]
# RefSeq	XP_016879666	XM_017024177.1. [Q8N370-1]
# RefSeq	XP_016879667	XM_017024178.1. [Q8N370-1]
# SEQUENCE CAUTION	Sequence=BAC11383.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11450.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the SLC43A transporter (TC 2.A.1.44) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	LAT4_HUMAN	Membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUPFAM	SSF103473	SSF103473; 3
# TCDB	2.A.1.44	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	Detected in several tissues with higher expression in placenta, kidney and peripheral blood leukocytes. In the kidney, is detected in epithelial cells of the distal tubule and collecting duct. In the intestine, is expressed mainly in crypt cells of the intestinal microvilli and epithelial cells in the base of the villus. {ECO:0000269|PubMed	15659399}. 
# UCSC	uc002fsu	human. [Q8N370-1]
# eggNOG	ENOG410IHJQ	Eukaryota
# eggNOG	ENOG410XS1N	LUCA
BLAST	swissprot:LAT4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:LAT4_HUMAN
BioCyc	ZFISH:ENSG00000167703-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000167703-MONOMER
COXPRESdb	124935	http://coxpresdb.jp/data/gene/124935.shtml
CleanEx	HS_SLC43A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC43A2
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0404089101	http://dx.doi.org/10.1073/pnas.0404089101
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/jbc.M408638200	http://dx.doi.org/10.1074/jbc.M408638200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB120364	http://www.ebi.ac.uk/ena/data/view/AB120364
EMBL	AC100748	http://www.ebi.ac.uk/ena/data/view/AC100748
EMBL	AC130343	http://www.ebi.ac.uk/ena/data/view/AC130343
EMBL	AF289592	http://www.ebi.ac.uk/ena/data/view/AF289592
EMBL	AK075068	http://www.ebi.ac.uk/ena/data/view/AK075068
EMBL	AK075173	http://www.ebi.ac.uk/ena/data/view/AK075173
EMBL	AK301127	http://www.ebi.ac.uk/ena/data/view/AK301127
EMBL	BC027923	http://www.ebi.ac.uk/ena/data/view/BC027923
EMBL	BC071859	http://www.ebi.ac.uk/ena/data/view/BC071859
EMBL	BK005642	http://www.ebi.ac.uk/ena/data/view/BK005642
EMBL	CH471108	http://www.ebi.ac.uk/ena/data/view/CH471108
EMBL	CH471108	http://www.ebi.ac.uk/ena/data/view/CH471108
EMBL	CH471108	http://www.ebi.ac.uk/ena/data/view/CH471108
EMBL	CH471108	http://www.ebi.ac.uk/ena/data/view/CH471108
Ensembl	ENST00000301335	http://www.ensembl.org/id/ENST00000301335
Ensembl	ENST00000382147	http://www.ensembl.org/id/ENST00000382147
Ensembl	ENST00000412517	http://www.ensembl.org/id/ENST00000412517
Ensembl	ENST00000571650	http://www.ensembl.org/id/ENST00000571650
Ensembl	ENST00000612931	http://www.ensembl.org/id/ENST00000612931
Ensembl	ENST00000613070	http://www.ensembl.org/id/ENST00000613070
Ensembl	ENST00000634102	http://www.ensembl.org/id/ENST00000634102
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_function	GO:0015175	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015175
GO_function	GO:0015179	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015179
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC43A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC43A2
GeneID	124935	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=124935
GeneTree	ENSGT00530000063043	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063043
H-InvDB	HIX0017704	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0017704
H-InvDB	HIX0039573	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0039573
HGNC	HGNC:23087	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:23087
HOGENOM	HOG000231937	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231937&db=HOGENOM6
HOVERGEN	HBG072879	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG072879&db=HOVERGEN
HPA	HPA021564	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA021564
InParanoid	Q8N370	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8N370
IntAct	Q8N370	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8N370*
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
InterPro	IPR027201	http://www.ebi.ac.uk/interpro/entry/IPR027201
Jabion	124935	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=124935
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:124935	http://www.genome.jp/dbget-bin/www_bget?hsa:124935
KEGG_Orthology	KO:K08229	http://www.genome.jp/dbget-bin/www_bget?KO:K08229
MIM	610791	http://www.ncbi.nlm.nih.gov/omim/610791
MINT	MINT-4724578	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4724578
OMA	FYSYLCK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FYSYLCK
OrthoDB	EOG091G0407	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0407
PANTHER	PTHR20766:SF2	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20766:SF2
PSORT	swissprot:LAT4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:LAT4_HUMAN
PSORT-B	swissprot:LAT4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:LAT4_HUMAN
PSORT2	swissprot:LAT4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:LAT4_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA134940765	http://www.pharmgkb.org/do/serve?objId=PA134940765&objCls=Gene
Phobius	swissprot:LAT4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:LAT4_HUMAN
PhylomeDB	Q8N370	http://phylomedb.org/?seqid=Q8N370
ProteinModelPortal	Q8N370	http://www.proteinmodelportal.org/query/uniprot/Q8N370
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15498874	http://www.ncbi.nlm.nih.gov/pubmed/15498874
PubMed	15659399	http://www.ncbi.nlm.nih.gov/pubmed/15659399
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
Reactome	R-HSA-352230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-352230
RefSeq	NP_001271427	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001271427
RefSeq	NP_001271428	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001271428
RefSeq	NP_001308293	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001308293
RefSeq	NP_001308294	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001308294
RefSeq	NP_689559	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_689559
RefSeq	XP_016879666	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016879666
RefSeq	XP_016879667	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016879667
STRING	9606.ENSP00000301335	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000301335&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.44	http://www.tcdb.org/search/result.php?tc=2.A.1.44
UCSC	uc002fsu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002fsu&org=rat
UniGene	Hs.160550	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.160550
UniGene	Hs.656337	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.656337
UniGene	Hs.732271	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.732271
UniProtKB	LAT4_HUMAN	http://www.uniprot.org/uniprot/LAT4_HUMAN
UniProtKB-AC	Q8N370	http://www.uniprot.org/uniprot/Q8N370
charge	swissprot:LAT4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:LAT4_HUMAN
eggNOG	ENOG410IHJQ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IHJQ
eggNOG	ENOG410XS1N	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS1N
epestfind	swissprot:LAT4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:LAT4_HUMAN
garnier	swissprot:LAT4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:LAT4_HUMAN
helixturnhelix	swissprot:LAT4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:LAT4_HUMAN
hmoment	swissprot:LAT4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:LAT4_HUMAN
iep	swissprot:LAT4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:LAT4_HUMAN
inforesidue	swissprot:LAT4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:LAT4_HUMAN
neXtProt	NX_Q8N370	http://www.nextprot.org/db/entry/NX_Q8N370
octanol	swissprot:LAT4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:LAT4_HUMAN
pepcoil	swissprot:LAT4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:LAT4_HUMAN
pepdigest	swissprot:LAT4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:LAT4_HUMAN
pepinfo	swissprot:LAT4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:LAT4_HUMAN
pepnet	swissprot:LAT4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:LAT4_HUMAN
pepstats	swissprot:LAT4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:LAT4_HUMAN
pepwheel	swissprot:LAT4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:LAT4_HUMAN
pepwindow	swissprot:LAT4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:LAT4_HUMAN
sigcleave	swissprot:LAT4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:LAT4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	UT1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13336-1; Sequence=Displayed; Name=2; IsoId=Q13336-2; Sequence=VSP_041573; 
# AltName	UT1_HUMAN	Solute carrier family 14 member 1
# AltName	UT1_HUMAN	Urea transporter, erythrocyte
# CCDS	CCDS11925	-. [Q13336-1]
# CCDS	CCDS45860	-. [Q13336-2]
# DrugBank	DB03904	Urea
# Ensembl	ENST00000321925	ENSP00000318546; ENSG00000141469. [Q13336-1]
# Ensembl	ENST00000415427	ENSP00000412309; ENSG00000141469. [Q13336-2]
# Ensembl	ENST00000436407	ENSP00000390637; ENSG00000141469. [Q13336-2]
# Ensembl	ENST00000586142	ENSP00000470476; ENSG00000141469. [Q13336-1]
# ExpressionAtlas	Q13336	baseline and differential
# FUNCTION	UT1_HUMAN	Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means. 
# GO_component	GO:0005730	nucleolus; IDA:HPA.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_function	GO:0005372	water transmembrane transporter activity; IEA:Ensembl.
# GO_function	GO:0015204	urea transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015265	urea channel activity; IDA:UniProtKB.
# GO_process	GO:0015840	urea transport; TAS:ProtInc.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GO_process	GO:0071918	urea transmembrane transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005730	nucleolus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.10.3430.10	-; 1.
# Genevisible	Q13336	HS
# HGNC	HGNC:10918	SLC14A1
# InterPro	IPR004937	Urea_transporter
# InterPro	IPR029020	Ammonium/urea_transptr
# KEGG_Brite	ko02001	Solute carrier family
# MIM	111000	phenotype
# MIM	613868	gene
# Organism	UT1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10464	PTHR10464
# PIR	A55662	A55662
# PIRSF	PIRSF016502	Urea_transporter
# POLYMORPHISM	SLC14A1 is responsible for the Kidd blood group system (JK) [MIM	111000]. JK is defined by 2 alleles, JK*01 and JK*02 that give rise to Jk(a) and Jk(b) antigens respectively. The molecular basis of the Jk(a)/Jk(b) antigens is a single variation in position 280; Asp-280 corresponds to Jk(a) and Asn-280 to Jk(b). Some individuals carry silenced JK*01 and JK*02 alleles, designated JK*01N or JK*02N. They results in a Jk(null) phenotype associated with reduced urea permeability of red blood cells. Jk(null) is not associated with any obvious clinical syndrome except for a urine concentration defect. 
# Pfam	PF03253	UT
# Proteomes	UP000005640	Chromosome 18
# Reactome	R-HSA-425366	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
# RecName	UT1_HUMAN	Urea transporter 1
# RefSeq	NP_001122060	NM_001128588.3. [Q13336-2]
# RefSeq	NP_001139508	NM_001146036.2. [Q13336-1]
# RefSeq	NP_001139509	NM_001146037.1. [Q13336-2]
# RefSeq	NP_056949	NM_015865.6. [Q13336-1]
# SIMILARITY	Belongs to the urea transporter family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	UT1_HUMAN	Cell membrane {ECO 0000269|PubMed 23219802}; Multi-pass membrane protein {ECO 0000269|PubMed 23219802}. Basolateral cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Note=Restricted to the basolateral membrane in various portions of the urothelium. {ECO 0000250}. 
# SUBUNIT	Homotrimer; each subunit contains a pore through which urea permeates. Identified in a complex with STOM (By similarity). {ECO	0000250}. 
# TCDB	1.A.28.1	the urea transporter (ut) family
# TISSUE SPECIFICITY	Detected in erythrocytes (at protein level). Erythrocytes. {ECO:0000269|PubMed	23219802}. 
# UCSC	uc002lbf	human. [Q13336-1]
# WEB RESOURCE	UT1_HUMAN	Name=SeattleSNPs; URL="http //pga.gs.washington.edu/data/slc14a1/";
# WEB RESOURCE	UT1_HUMAN	Name=dbRBC/BGMUT; Note=Blood group antigen gene mutation database; URL="https //www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=kidd"; 
# eggNOG	COG4413	LUCA
# eggNOG	ENOG410IEWG	Eukaryota
BLAST	swissprot:UT1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:UT1_HUMAN
BioCyc	ZFISH:ENSG00000141469-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000141469-MONOMER
COXPRESdb	6563	http://coxpresdb.jp/data/gene/6563.shtml
CleanEx	HS_SLC14A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC14A1
DIP	DIP-60049N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-60049N
DOI	10.1016/j.bbamem.2012.11.030	http://dx.doi.org/10.1016/j.bbamem.2012.11.030
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1046/j.1537-2995.2000.40010069.x	http://dx.doi.org/10.1046/j.1537-2995.2000.40010069.x
DOI	10.1074/jbc.274.42.30228	http://dx.doi.org/10.1074/jbc.274.42.30228
DOI	10.1091/mbc.6.10.1411	http://dx.doi.org/10.1091/mbc.6.10.1411
DOI	10.1093/hmg/6.7.1017	http://dx.doi.org/10.1093/hmg/6.7.1017
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1537-2995.2007.01532.x	http://dx.doi.org/10.1111/j.1537-2995.2007.01532.x
DOI	10.1111/j.1537-2995.2008.01958.x	http://dx.doi.org/10.1111/j.1537-2995.2008.01958.x
DrugBank	DB03904	http://www.drugbank.ca/drugs/DB03904
EMBL	AK091064	http://www.ebi.ac.uk/ena/data/view/AK091064
EMBL	AK123681	http://www.ebi.ac.uk/ena/data/view/AK123681
EMBL	AK289608	http://www.ebi.ac.uk/ena/data/view/AK289608
EMBL	AY942197	http://www.ebi.ac.uk/ena/data/view/AY942197
EMBL	BC050539	http://www.ebi.ac.uk/ena/data/view/BC050539
EMBL	EF571316	http://www.ebi.ac.uk/ena/data/view/EF571316
EMBL	EF571317	http://www.ebi.ac.uk/ena/data/view/EF571317
EMBL	EF571318	http://www.ebi.ac.uk/ena/data/view/EF571318
EMBL	GQ502682	http://www.ebi.ac.uk/ena/data/view/GQ502682
EMBL	L36121	http://www.ebi.ac.uk/ena/data/view/L36121
EMBL	U35735	http://www.ebi.ac.uk/ena/data/view/U35735
EMBL	Y19039	http://www.ebi.ac.uk/ena/data/view/Y19039
Ensembl	ENST00000321925	http://www.ensembl.org/id/ENST00000321925
Ensembl	ENST00000415427	http://www.ensembl.org/id/ENST00000415427
Ensembl	ENST00000436407	http://www.ensembl.org/id/ENST00000436407
Ensembl	ENST00000586142	http://www.ensembl.org/id/ENST00000586142
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005730
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0005372	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005372
GO_function	GO:0015204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015204
GO_function	GO:0015265	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015265
GO_process	GO:0015840	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015840
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GO_process	GO:0071918	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071918
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005730
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.10.3430.10	http://www.cathdb.info/version/latest/superfamily/1.10.3430.10
GeneCards	SLC14A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC14A1
GeneID	6563	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6563
GeneTree	ENSGT00390000018729	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000018729
HGNC	HGNC:10918	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10918
HOGENOM	HOG000065705	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000065705&db=HOGENOM6
HOVERGEN	HBG000540	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000540&db=HOVERGEN
HPA	HPA058353	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA058353
HPA	HPA059570	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA059570
InParanoid	Q13336	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q13336
InterPro	IPR004937	http://www.ebi.ac.uk/interpro/entry/IPR004937
InterPro	IPR029020	http://www.ebi.ac.uk/interpro/entry/IPR029020
Jabion	6563	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6563
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6563	http://www.genome.jp/dbget-bin/www_bget?hsa:6563
KEGG_Orthology	KO:K08716	http://www.genome.jp/dbget-bin/www_bget?KO:K08716
MIM	111000	http://www.ncbi.nlm.nih.gov/omim/111000
MIM	613868	http://www.ncbi.nlm.nih.gov/omim/613868
OMA	MGGMFMA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MGGMFMA
OrthoDB	EOG091G095L	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G095L
PANTHER	PTHR10464	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10464
PSORT	swissprot:UT1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:UT1_HUMAN
PSORT-B	swissprot:UT1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:UT1_HUMAN
PSORT2	swissprot:UT1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:UT1_HUMAN
Pfam	PF03253	http://pfam.xfam.org/family/PF03253
PharmGKB	PA35810	http://www.pharmgkb.org/do/serve?objId=PA35810&objCls=Gene
Phobius	swissprot:UT1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:UT1_HUMAN
PhylomeDB	Q13336	http://phylomedb.org/?seqid=Q13336
ProteinModelPortal	Q13336	http://www.proteinmodelportal.org/query/uniprot/Q13336
PubMed	10514515	http://www.ncbi.nlm.nih.gov/pubmed/10514515
PubMed	10644814	http://www.ncbi.nlm.nih.gov/pubmed/10644814
PubMed	10942407	http://www.ncbi.nlm.nih.gov/pubmed/10942407
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18028269	http://www.ncbi.nlm.nih.gov/pubmed/18028269
PubMed	18980618	http://www.ncbi.nlm.nih.gov/pubmed/18980618
PubMed	23219802	http://www.ncbi.nlm.nih.gov/pubmed/23219802
PubMed	7989337	http://www.ncbi.nlm.nih.gov/pubmed/7989337
PubMed	8573795	http://www.ncbi.nlm.nih.gov/pubmed/8573795
PubMed	9215669	http://www.ncbi.nlm.nih.gov/pubmed/9215669
Reactome	R-HSA-425366	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425366
RefSeq	NP_001122060	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001122060
RefSeq	NP_001139508	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001139508
RefSeq	NP_001139509	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001139509
RefSeq	NP_056949	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_056949
SMR	Q13336	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q13336
STRING	9606.ENSP00000390637	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000390637&targetmode=cogs
TCDB	1.A.28.1	http://www.tcdb.org/search/result.php?tc=1.A.28.1
UCSC	uc002lbf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002lbf&org=rat
UniGene	Hs.101307	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.101307
UniProtKB	UT1_HUMAN	http://www.uniprot.org/uniprot/UT1_HUMAN
UniProtKB-AC	Q13336	http://www.uniprot.org/uniprot/Q13336
charge	swissprot:UT1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:UT1_HUMAN
eggNOG	COG4413	http://eggnogapi.embl.de/nog_data/html/tree/COG4413
eggNOG	ENOG410IEWG	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IEWG
epestfind	swissprot:UT1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:UT1_HUMAN
garnier	swissprot:UT1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:UT1_HUMAN
helixturnhelix	swissprot:UT1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:UT1_HUMAN
hmoment	swissprot:UT1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:UT1_HUMAN
iep	swissprot:UT1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:UT1_HUMAN
inforesidue	swissprot:UT1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:UT1_HUMAN
neXtProt	NX_Q13336	http://www.nextprot.org/db/entry/NX_Q13336
octanol	swissprot:UT1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:UT1_HUMAN
pepcoil	swissprot:UT1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:UT1_HUMAN
pepdigest	swissprot:UT1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:UT1_HUMAN
pepinfo	swissprot:UT1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:UT1_HUMAN
pepnet	swissprot:UT1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:UT1_HUMAN
pepstats	swissprot:UT1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:UT1_HUMAN
pepwheel	swissprot:UT1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:UT1_HUMAN
pepwindow	swissprot:UT1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:UT1_HUMAN
sigcleave	swissprot:UT1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:UT1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AT1A1_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Long; IsoId=P05023-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=P05023-2; Sequence=VSP_000415, VSP_000416; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; IsoId=P05023-3; Sequence=VSP_044242; Name=4; IsoId=P05023-4; Sequence=VSP_047309; 
# AltName	AT1A1_HUMAN	Sodium pump subunit alpha-1
# BioGrid	106966	120
# CATALYTIC ACTIVITY	AT1A1_HUMAN	ATP + H(2)O + Na(+)(In) + K(+)(Out) = ADP + phosphate + Na(+)(Out) + K(+)(In). 
# CCDS	CCDS53351	-. [P05023-4]
# CCDS	CCDS53352	-. [P05023-3]
# CCDS	CCDS887	-. [P05023-1]
# ChiTaRS	ATP1A1	human
# DrugBank	DB00390	Digoxin
# DrugBank	DB00511	Acetyldigitoxin
# DrugBank	DB00774	Hydroflumethiazide
# DrugBank	DB00903	Ethacrynic acid
# DrugBank	DB01021	Trichlormethiazide
# DrugBank	DB01078	Deslanoside
# DrugBank	DB01092	Ouabain
# DrugBank	DB01119	Diazoxide
# DrugBank	DB01158	Bretylium
# DrugBank	DB01188	Ciclopirox
# DrugBank	DB01244	Bepridil
# DrugBank	DB01345	Potassium
# DrugBank	DB01370	Aluminium
# DrugBank	DB01396	Digitoxin
# DrugBank	DB01430	Almitrine
# Ensembl	ENST00000295598	ENSP00000295598; ENSG00000163399. [P05023-1]
# Ensembl	ENST00000369496	ENSP00000358508; ENSG00000163399. [P05023-3]
# Ensembl	ENST00000537345	ENSP00000445306; ENSG00000163399. [P05023-4]
# ExpressionAtlas	P05023	baseline and differential
# FUNCTION	AT1A1_HUMAN	This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. 
# GO_component	AT1A1_HUMAN	GO 0005890 sodium potassium-exchanging ATPase complex; IDA BHF-UCL.
# GO_component	GO:0005768	endosome; IEA:Ensembl.
# GO_component	GO:0005783	endoplasmic reticulum; ISS:BHF-UCL.
# GO_component	GO:0005794	Golgi apparatus; ISS:BHF-UCL.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005901	caveola; IEA:Ensembl.
# GO_component	GO:0014069	postsynaptic density; IEA:Ensembl.
# GO_component	GO:0014704	intercalated disc; IEA:Ensembl.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0016021	integral component of membrane; ISS:UniProtKB.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:Ensembl.
# GO_component	GO:0016324	apical plasma membrane; IEA:Ensembl.
# GO_component	GO:0030315	T-tubule; IEA:Ensembl.
# GO_component	GO:0042383	sarcolemma; ISS:BHF-UCL.
# GO_component	GO:0042470	melanosome; IEA:UniProtKB-SubCell.
# GO_component	GO:0043209	myelin sheath; IEA:Ensembl.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IBA:GO_Central.
# GO_component	GO:0043234	protein complex; IDA:MGI.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_component	GO:1903561	extracellular vesicle; IDA:UniProtKB.
# GO_function	AT1A1_HUMAN	GO 0005391 sodium potassium-exchanging ATPase activity; ISS UniProtKB.
# GO_function	GO:0005524	ATP binding; ISS:BHF-UCL.
# GO_function	GO:0016791	phosphatase activity; IEA:Ensembl.
# GO_function	GO:0030955	potassium ion binding; ISS:BHF-UCL.
# GO_function	GO:0031402	sodium ion binding; ISS:BHF-UCL.
# GO_function	GO:0043531	ADP binding; IEA:Ensembl.
# GO_function	GO:0051087	chaperone binding; IPI:BHF-UCL.
# GO_function	GO:1990239	steroid hormone binding; IDA:BHF-UCL.
# GO_process	GO:0002026	regulation of the force of heart contraction; IEA:Ensembl.
# GO_process	GO:0002028	regulation of sodium ion transport; ISS:UniProtKB.
# GO_process	GO:0006883	cellular sodium ion homeostasis; IDA:BHF-UCL.
# GO_process	GO:0008217	regulation of blood pressure; IEA:Ensembl.
# GO_process	GO:0010107	potassium ion import; IDA:BHF-UCL.
# GO_process	GO:0015991	ATP hydrolysis coupled proton transport; IBA:GO_Central.
# GO_process	GO:0030007	cellular potassium ion homeostasis; IDA:BHF-UCL.
# GO_process	GO:0031947	negative regulation of glucocorticoid biosynthetic process; IEA:Ensembl.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0036376	sodium ion export from cell; IDA:BHF-UCL.
# GO_process	GO:0042493	response to drug; IEA:Ensembl.
# GO_process	GO:0045822	negative regulation of heart contraction; IEA:Ensembl.
# GO_process	GO:0045823	positive regulation of heart contraction; IEA:Ensembl.
# GO_process	GO:0045989	positive regulation of striated muscle contraction; IEA:Ensembl.
# GO_process	GO:0055119	relaxation of cardiac muscle; TAS:BHF-UCL.
# GO_process	GO:0060048	cardiac muscle contraction; TAS:BHF-UCL.
# GO_process	GO:0060081	membrane hyperpolarization; IEA:Ensembl.
# GO_process	GO:0071260	cellular response to mechanical stimulus; IEA:Ensembl.
# GO_process	GO:0071383	cellular response to steroid hormone stimulus; IDA:BHF-UCL.
# GO_process	GO:0086004	regulation of cardiac muscle cell contraction; IEA:Ensembl.
# GO_process	GO:0086009	membrane repolarization; IDA:BHF-UCL.
# GO_process	GO:0086013	membrane repolarization during cardiac muscle cell action potential; IC:BHF-UCL.
# GO_process	GO:0086064	cell communication by electrical coupling involved in cardiac conduction; TAS:BHF-UCL.
# GO_process	GO:1903416	response to glycoside; IDA:BHF-UCL.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GO_process	GO:1990573	potassium ion import across plasma membrane; ISS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008289	lipid binding
# GOslim_function	GO:0016791	phosphatase activity
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.1110.10	-; 2.
# Gene3D	2.70.150.10	-; 2.
# Gene3D	3.40.1110.10	-; 1.
# Genevisible	P05023	HS
# HGNC	HGNC:799	ATP1A1
# INTERACTION	AT1A1_HUMAN	P13693 TPT1; NbExp=5; IntAct=EBI-358778, EBI-1783169; 
# IntAct	P05023	58
# InterPro	IPR001757	P_typ_ATPase
# InterPro	IPR004014	ATPase_P-typ_cation-transptr_N
# InterPro	IPR005775	P-type_ATPase_IIC
# InterPro	IPR006068	ATPase_P-typ_cation-transptr_C
# InterPro	IPR008250	ATPase_P-typ_transduc_dom_A
# InterPro	IPR018303	ATPase_P-typ_P_site
# InterPro	IPR023214	HAD-like_dom
# InterPro	IPR023298	ATPase_P-typ_TM_dom
# InterPro	IPR023299	ATPase_P-typ_cyto_domN
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Disease	H01603	[Endocrine disease] Primary aldosteronism
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko04960	Aldosterone-regulated sodium reabsorption
# KEGG_Pathway	ko04961	Endocrine and other factor-regulated calcium reabsorption
# KEGG_Pathway	ko04964	Proximal tubule bicarbonate reclamation
# KEGG_Pathway	ko04970	Salivary secretion
# KEGG_Pathway	ko04971	Gastric acid secretion
# KEGG_Pathway	ko04972	Pancreatic secretion
# KEGG_Pathway	ko04973	Carbohydrate digestion and absorption
# KEGG_Pathway	ko04974	Protein digestion and absorption
# KEGG_Pathway	ko04976	Bile secretion
# KEGG_Pathway	ko04978	Mineral absorption
# MIM	182310	gene
# Organism	AT1A1_HUMAN	Homo sapiens (Human)
# Orphanet	85142	Aldosterone-producing adenoma
# PIR	A24414	A24414
# PROSITE	PS00154	ATPASE_E1_E2
# PTM	AT1A1_HUMAN	Phosphorylation on Tyr-10 modulates pumping activity. Phosphorylation of Ser-943 by PKA modulates the response of ATP1A1 to PKC. Dephosphorylation by protein phosphatase 2A (PP2A) following increases in intracellular sodium, leading to increase catalytic activity (By similarity). {ECO 0000250}. 
# Pfam	PF00122	E1-E2_ATPase
# Pfam	PF00689	Cation_ATPase_C
# Pfam	PF00690	Cation_ATPase_N
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-5578775	Ion homeostasis
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	AT1A1_HUMAN	Sodium/potassium-transporting ATPase subunit alpha-1
# RefSeq	NP_000692	NM_000701.7. [P05023-1]
# RefSeq	NP_001153705	NM_001160233.1. [P05023-4]
# RefSeq	NP_001153706	NM_001160234.1. [P05023-3]
# RefSeq	XP_016856849	XM_017001360.1. [P05023-3]
# RefSeq	XP_016856850	XM_017001361.1. [P05023-3]
# SIMILARITY	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. {ECO	0000305}.
# SMART	SM00831	Cation_ATPase_N
# SUBCELLULAR LOCATION	AT1A1_HUMAN	Cell membrane {ECO 0000269|PubMed 7711835}; Multi-pass membrane protein {ECO 0000255}. Melanosome {ECO 0000269|PubMed 17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO 0000269|PubMed 17081065}. 
# SUBUNIT	AT1A1_HUMAN	Interacts with SIK1 (By similarity). Composed of three subunits  alpha (catalytic), beta and gamma. Binds the HLA class II histocompatibility antigen, DR1. Interacts with SLC35G1 and STIM1. {ECO 0000250, ECO 0000269|PubMed 1380674, ECO 0000269|PubMed 22084111}. 
# SUPFAM	SSF56784	SSF56784; 3
# SUPFAM	SSF81660	SSF81660
# TCDB	3.A.3.1	the p-type atpase (p-atpase) superfamily
# TIGRFAMs	TIGR01106	ATPase-IIC_X-K
# TIGRFAMs	TIGR01494	ATPase_P-type; 2
# UCSC	uc001ege	human. [P05023-1]
# eggNOG	COG0474	LUCA
# eggNOG	KOG0203	Eukaryota
BLAST	swissprot:AT1A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AT1A1_HUMAN
BioCyc	ZFISH:HS08843-MONOMER	http://biocyc.org/getid?id=ZFISH:HS08843-MONOMER
COXPRESdb	476	http://coxpresdb.jp/data/gene/476.shtml
CleanEx	HS_ATP1A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP1A1
DIP	DIP-38196N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-38196N
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/0014-5793(87)80677-4	http://dx.doi.org/10.1016/0014-5793(87)80677-4
DOI	10.1016/0378-1119(94)00812-7	http://dx.doi.org/10.1016/0378-1119(94)00812-7
DOI	10.1016/0888-7543(90)90475-A	http://dx.doi.org/10.1016/0888-7543(90)90475-A
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr060363j	http://dx.doi.org/10.1021/pr060363j
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/358764a0	http://dx.doi.org/10.1038/358764a0
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.1117231108	http://dx.doi.org/10.1073/pnas.1117231108
DOI	10.1073/pnas.84.12.4039	http://dx.doi.org/10.1073/pnas.84.12.4039
DOI	10.1073/pnas.84.22.7901	http://dx.doi.org/10.1073/pnas.84.22.7901
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1186/gb-2004-5-2-r8	http://dx.doi.org/10.1186/gb-2004-5-2-r8
DOI	10.3109/09687689409160435	http://dx.doi.org/10.3109/09687689409160435
DrugBank	DB00390	http://www.drugbank.ca/drugs/DB00390
DrugBank	DB00511	http://www.drugbank.ca/drugs/DB00511
DrugBank	DB00774	http://www.drugbank.ca/drugs/DB00774
DrugBank	DB00903	http://www.drugbank.ca/drugs/DB00903
DrugBank	DB01021	http://www.drugbank.ca/drugs/DB01021
DrugBank	DB01078	http://www.drugbank.ca/drugs/DB01078
DrugBank	DB01092	http://www.drugbank.ca/drugs/DB01092
DrugBank	DB01119	http://www.drugbank.ca/drugs/DB01119
DrugBank	DB01158	http://www.drugbank.ca/drugs/DB01158
DrugBank	DB01188	http://www.drugbank.ca/drugs/DB01188
DrugBank	DB01244	http://www.drugbank.ca/drugs/DB01244
DrugBank	DB01345	http://www.drugbank.ca/drugs/DB01345
DrugBank	DB01370	http://www.drugbank.ca/drugs/DB01370
DrugBank	DB01396	http://www.drugbank.ca/drugs/DB01396
DrugBank	DB01430	http://www.drugbank.ca/drugs/DB01430
EC_number	EC:3.6.3.9	http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.9
EMBL	AK295095	http://www.ebi.ac.uk/ena/data/view/AK295095
EMBL	AK296362	http://www.ebi.ac.uk/ena/data/view/AK296362
EMBL	AK314777	http://www.ebi.ac.uk/ena/data/view/AK314777
EMBL	AL136376	http://www.ebi.ac.uk/ena/data/view/AL136376
EMBL	BC001330	http://www.ebi.ac.uk/ena/data/view/BC001330
EMBL	BC003077	http://www.ebi.ac.uk/ena/data/view/BC003077
EMBL	BC050359	http://www.ebi.ac.uk/ena/data/view/BC050359
EMBL	CH471122	http://www.ebi.ac.uk/ena/data/view/CH471122
EMBL	D00099	http://www.ebi.ac.uk/ena/data/view/D00099
EMBL	J03007	http://www.ebi.ac.uk/ena/data/view/J03007
EMBL	L76938	http://www.ebi.ac.uk/ena/data/view/L76938
EMBL	M16793	http://www.ebi.ac.uk/ena/data/view/M16793
EMBL	M16794	http://www.ebi.ac.uk/ena/data/view/M16794
EMBL	M27572	http://www.ebi.ac.uk/ena/data/view/M27572
EMBL	M27579	http://www.ebi.ac.uk/ena/data/view/M27579
EMBL	M30309	http://www.ebi.ac.uk/ena/data/view/M30309
EMBL	M30310	http://www.ebi.ac.uk/ena/data/view/M30310
EMBL	U16798	http://www.ebi.ac.uk/ena/data/view/U16798
EMBL	X03757	http://www.ebi.ac.uk/ena/data/view/X03757
EMBL	X04297	http://www.ebi.ac.uk/ena/data/view/X04297
ENZYME	3.6.3.9	http://enzyme.expasy.org/EC/3.6.3.9
Ensembl	ENST00000295598	http://www.ensembl.org/id/ENST00000295598
Ensembl	ENST00000369496	http://www.ensembl.org/id/ENST00000369496
Ensembl	ENST00000537345	http://www.ensembl.org/id/ENST00000537345
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005890
GO_component	GO:0005901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005901
GO_component	GO:0014069	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014069
GO_component	GO:0014704	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014704
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0030315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030315
GO_component	GO:0042383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042383
GO_component	GO:0042470	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042470
GO_component	GO:0043209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043209
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_component	GO:1903561	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903561
GO_function	GO:0005391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005391
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0016791	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791
GO_function	GO:0030955	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030955
GO_function	GO:0031402	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031402
GO_function	GO:0043531	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043531
GO_function	GO:0051087	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051087
GO_function	GO:1990239	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990239
GO_process	GO:0002026	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002026
GO_process	GO:0002028	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002028
GO_process	GO:0006883	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006883
GO_process	GO:0008217	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008217
GO_process	GO:0010107	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010107
GO_process	GO:0015991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015991
GO_process	GO:0030007	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030007
GO_process	GO:0031947	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031947
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0036376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036376
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0045822	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045822
GO_process	GO:0045823	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045823
GO_process	GO:0045989	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045989
GO_process	GO:0055119	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055119
GO_process	GO:0060048	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060048
GO_process	GO:0060081	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060081
GO_process	GO:0071260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071260
GO_process	GO:0071383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071383
GO_process	GO:0086004	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086004
GO_process	GO:0086009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086009
GO_process	GO:0086013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086013
GO_process	GO:0086064	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086064
GO_process	GO:1903416	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903416
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GO_process	GO:1990573	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990573
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GOslim_function	GO:0016791	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.1110.10	http://www.cathdb.info/version/latest/superfamily/1.20.1110.10
Gene3D	2.70.150.10	http://www.cathdb.info/version/latest/superfamily/2.70.150.10
Gene3D	3.40.1110.10	http://www.cathdb.info/version/latest/superfamily/3.40.1110.10
GeneCards	ATP1A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP1A1
GeneID	476	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=476
GeneTree	ENSGT00850000132256	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00850000132256
HGNC	HGNC:799	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:799
HOGENOM	HOG000265622	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265622&db=HOGENOM6
HOVERGEN	HBG004298	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004298&db=HOVERGEN
HPA	CAB018702	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB018702
InParanoid	P05023	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P05023
IntAct	P05023	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P05023*
IntEnz	3.6.3.9	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.9
InterPro	IPR001757	http://www.ebi.ac.uk/interpro/entry/IPR001757
InterPro	IPR004014	http://www.ebi.ac.uk/interpro/entry/IPR004014
InterPro	IPR005775	http://www.ebi.ac.uk/interpro/entry/IPR005775
InterPro	IPR006068	http://www.ebi.ac.uk/interpro/entry/IPR006068
InterPro	IPR008250	http://www.ebi.ac.uk/interpro/entry/IPR008250
InterPro	IPR018303	http://www.ebi.ac.uk/interpro/entry/IPR018303
InterPro	IPR023214	http://www.ebi.ac.uk/interpro/entry/IPR023214
InterPro	IPR023298	http://www.ebi.ac.uk/interpro/entry/IPR023298
InterPro	IPR023299	http://www.ebi.ac.uk/interpro/entry/IPR023299
Jabion	476	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=476
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Disease	H01603	http://www.genome.jp/dbget-bin/www_bget?H01603
KEGG_Gene	hsa:476	http://www.genome.jp/dbget-bin/www_bget?hsa:476
KEGG_Orthology	KO:K01539	http://www.genome.jp/dbget-bin/www_bget?KO:K01539
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko04960	http://www.genome.jp/kegg-bin/show_pathway?ko04960
KEGG_Pathway	ko04961	http://www.genome.jp/kegg-bin/show_pathway?ko04961
KEGG_Pathway	ko04964	http://www.genome.jp/kegg-bin/show_pathway?ko04964
KEGG_Pathway	ko04970	http://www.genome.jp/kegg-bin/show_pathway?ko04970
KEGG_Pathway	ko04971	http://www.genome.jp/kegg-bin/show_pathway?ko04971
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
KEGG_Pathway	ko04973	http://www.genome.jp/kegg-bin/show_pathway?ko04973
KEGG_Pathway	ko04974	http://www.genome.jp/kegg-bin/show_pathway?ko04974
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
KEGG_Pathway	ko04978	http://www.genome.jp/kegg-bin/show_pathway?ko04978
MIM	182310	http://www.ncbi.nlm.nih.gov/omim/182310
MINT	MINT-4998863	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4998863
OMA	PVENLCF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PVENLCF
Orphanet	85142	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=85142
OrthoDB	EOG091G01BB	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01BB
PROSITE	PS00154	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00154
PSORT	swissprot:AT1A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AT1A1_HUMAN
PSORT-B	swissprot:AT1A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AT1A1_HUMAN
PSORT2	swissprot:AT1A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AT1A1_HUMAN
Pfam	PF00122	http://pfam.xfam.org/family/PF00122
Pfam	PF00689	http://pfam.xfam.org/family/PF00689
Pfam	PF00690	http://pfam.xfam.org/family/PF00690
PharmGKB	PA62	http://www.pharmgkb.org/do/serve?objId=PA62&objCls=Gene
Phobius	swissprot:AT1A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AT1A1_HUMAN
PhylomeDB	P05023	http://phylomedb.org/?seqid=P05023
ProteinModelPortal	P05023	http://www.proteinmodelportal.org/query/uniprot/P05023
PubMed	1380674	http://www.ncbi.nlm.nih.gov/pubmed/1380674
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	14759258	http://www.ncbi.nlm.nih.gov/pubmed/14759258
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17081065	http://www.ncbi.nlm.nih.gov/pubmed/17081065
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	1970326	http://www.ncbi.nlm.nih.gov/pubmed/1970326
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22084111	http://www.ncbi.nlm.nih.gov/pubmed/22084111
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	2430951	http://www.ncbi.nlm.nih.gov/pubmed/2430951
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	2891135	http://www.ncbi.nlm.nih.gov/pubmed/2891135
PubMed	3035563	http://www.ncbi.nlm.nih.gov/pubmed/3035563
PubMed	3036582	http://www.ncbi.nlm.nih.gov/pubmed/3036582
PubMed	7536695	http://www.ncbi.nlm.nih.gov/pubmed/7536695
PubMed	7711835	http://www.ncbi.nlm.nih.gov/pubmed/7711835
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_000692	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000692
RefSeq	NP_001153705	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001153705
RefSeq	NP_001153706	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001153706
RefSeq	XP_016856849	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016856849
RefSeq	XP_016856850	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016856850
SMART	SM00831	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00831
SMR	P05023	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P05023
STRING	9606.ENSP00000295598	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000295598&targetmode=cogs
SUPFAM	SSF56784	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784
SUPFAM	SSF81660	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81660
TCDB	3.A.3.1	http://www.tcdb.org/search/result.php?tc=3.A.3.1
TIGRFAMs	TIGR01106	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01106
TIGRFAMs	TIGR01494	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01494
UCSC	uc001ege	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001ege&org=rat
UniGene	Hs.371889	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.371889
UniProtKB	AT1A1_HUMAN	http://www.uniprot.org/uniprot/AT1A1_HUMAN
UniProtKB-AC	P05023	http://www.uniprot.org/uniprot/P05023
charge	swissprot:AT1A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AT1A1_HUMAN
eggNOG	COG0474	http://eggnogapi.embl.de/nog_data/html/tree/COG0474
eggNOG	KOG0203	http://eggnogapi.embl.de/nog_data/html/tree/KOG0203
epestfind	swissprot:AT1A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AT1A1_HUMAN
garnier	swissprot:AT1A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AT1A1_HUMAN
helixturnhelix	swissprot:AT1A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AT1A1_HUMAN
hmoment	swissprot:AT1A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AT1A1_HUMAN
iep	swissprot:AT1A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AT1A1_HUMAN
inforesidue	swissprot:AT1A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AT1A1_HUMAN
neXtProt	NX_P05023	http://www.nextprot.org/db/entry/NX_P05023
octanol	swissprot:AT1A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AT1A1_HUMAN
pepcoil	swissprot:AT1A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AT1A1_HUMAN
pepdigest	swissprot:AT1A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AT1A1_HUMAN
pepinfo	swissprot:AT1A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AT1A1_HUMAN
pepnet	swissprot:AT1A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AT1A1_HUMAN
pepstats	swissprot:AT1A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AT1A1_HUMAN
pepwheel	swissprot:AT1A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AT1A1_HUMAN
pepwindow	swissprot:AT1A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AT1A1_HUMAN
sigcleave	swissprot:AT1A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AT1A1_HUMAN
## Database	ID	URL or Descriptions
# AltName	CXA5_HUMAN	Connexin-40
# BioGrid	108969	6
# ChiTaRS	GJA5	human
# DISEASE	CXA5_HUMAN	Atrial fibrillation, familial, 11 (ATFB11) [MIM 614049]  A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. {ECO 0000269|PubMed 20650941}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CXA5_HUMAN	Atrial standstill 1 (ATRST1) [MIM 108770]  A rare arrhythmia characterized by the absence of electrical and mechanical activity in the atria. Electrocardiographically, it is characterized by bradycardia, the absence of P waves, and a junctional narrow complex escape rhythm. {ECO 0000269|PubMed 16790700}. Note=The disease may be caused by mutations affecting distinct genetic loci, including the gene represented in this entry. A rare GJA5 genotype has been detected in combination with a mutation in SCN5A in a large family with atrial standstill. 
# Ensembl	ENST00000579774	ENSP00000463851; ENSG00000265107
# Ensembl	ENST00000621517	ENSP00000484552; ENSG00000265107
# ExpressionAtlas	P36382	baseline and differential
# FUNCTION	CXA5_HUMAN	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. 
# GO_component	GO:0005887	integral component of plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0005921	gap junction; IDA:BHF-UCL.
# GO_component	GO:0005922	connexin complex; IDA:BHF-UCL.
# GO_component	GO:0014704	intercalated disc; IDA:BHF-UCL.
# GO_component	GO:0042995	cell projection; IEA:Ensembl.
# GO_function	GO:0055077	gap junction hemi-channel activity; IDA:BHF-UCL.
# GO_function	GO:0086075	gap junction channel activity involved in cardiac conduction electrical coupling; IDA:BHF-UCL.
# GO_function	GO:0086077	gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling; IDA:BHF-UCL.
# GO_process	GO:0001501	skeletal system development; IEA:Ensembl.
# GO_process	GO:0001525	angiogenesis; IEP:UniProtKB.
# GO_process	GO:0003105	negative regulation of glomerular filtration; IEA:Ensembl.
# GO_process	GO:0003151	outflow tract morphogenesis; IMP:BHF-UCL.
# GO_process	GO:0003158	endothelium development; IEA:Ensembl.
# GO_process	GO:0003161	cardiac conduction system development; IEA:Ensembl.
# GO_process	GO:0003174	mitral valve development; IMP:BHF-UCL.
# GO_process	GO:0003193	pulmonary valve formation; IMP:BHF-UCL.
# GO_process	GO:0003281	ventricular septum development; IMP:BHF-UCL.
# GO_process	GO:0003283	atrial septum development; IMP:BHF-UCL.
# GO_process	GO:0003284	septum primum development; IEA:Ensembl.
# GO_process	GO:0003294	atrial ventricular junction remodeling; IEA:Ensembl.
# GO_process	GO:0006813	potassium ion transport; IEA:Ensembl.
# GO_process	GO:0010643	cell communication by chemical coupling; IEA:Ensembl.
# GO_process	GO:0010652	positive regulation of cell communication by chemical coupling; IEA:Ensembl.
# GO_process	GO:0016264	gap junction assembly; IDA:BHF-UCL.
# GO_process	GO:0030326	embryonic limb morphogenesis; IEA:Ensembl.
# GO_process	GO:0035050	embryonic heart tube development; IEA:Ensembl.
# GO_process	GO:0035922	foramen ovale closure; IEA:Ensembl.
# GO_process	GO:0045776	negative regulation of blood pressure; IEA:Ensembl.
# GO_process	GO:0045907	positive regulation of vasoconstriction; IEA:Ensembl.
# GO_process	GO:0045909	positive regulation of vasodilation; IEA:Ensembl.
# GO_process	GO:0048844	artery morphogenesis; ISS:BHF-UCL.
# GO_process	GO:0051259	protein oligomerization; IEA:Ensembl.
# GO_process	GO:0055117	regulation of cardiac muscle contraction; IMP:BHF-UCL.
# GO_process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization; IEA:Ensembl.
# GO_process	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization; IMP:BHF-UCL.
# GO_process	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization; IEA:Ensembl.
# GO_process	GO:0060412	ventricular septum morphogenesis; IEA:Ensembl.
# GO_process	GO:0060413	atrial septum morphogenesis; IEA:Ensembl.
# GO_process	GO:0086005	ventricular cardiac muscle cell action potential; IEA:Ensembl.
# GO_process	GO:0086015	SA node cell action potential; IEA:Ensembl.
# GO_process	GO:0086053	AV node cell to bundle of His cell communication by electrical coupling; IMP:BHF-UCL.
# GO_process	GO:0086054	bundle of His cell to Purkinje myocyte communication by electrical coupling; IMP:BHF-UCL.
# GO_process	GO:0086064	cell communication by electrical coupling involved in cardiac conduction; IDA:BHF-UCL.
# GO_process	GO:0086091	regulation of heart rate by cardiac conduction; IEA:Ensembl.
# GO_process	GO:0098904	regulation of AV node cell action potential; IMP:BHF-UCL.
# GO_process	GO:0098905	regulation of bundle of His cell action potential; IMP:BHF-UCL.
# GO_process	GO:0098906	regulation of Purkinje myocyte action potential; IMP:BHF-UCL.
# GO_process	GO:0098910	regulation of atrial cardiac muscle cell action potential; IMP:BHF-UCL.
# GO_process	GO:1900133	regulation of renin secretion into blood stream; IEA:Ensembl.
# GO_process	GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential; IEA:Ensembl.
# GO_process	GO:1990029	vasomotion; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0003013	circulatory system process
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0022607	cellular component assembly
# GOslim_process	GO:0034330	cell junction organization
# GOslim_process	GO:0048646	anatomical structure formation involved in morphogenesis
# GOslim_process	GO:0048856	anatomical structure development
# Genevisible	P36382	HS
# HGNC	HGNC:4279	GJA5
# IntAct	P36382	3
# InterPro	IPR000500	Connexin
# InterPro	IPR002264	Connexin40
# InterPro	IPR013092	Connexin_N
# InterPro	IPR017990	Connexin_CS
# InterPro	IPR019570	Connexin_CCC
# InterPro	IPR031862	Cx40_C
# KEGG_Disease	H00731	[Cardiovascular disease] Atrial fibrillation
# MIM	108770	phenotype
# MIM	121013	gene
# MIM	614049	phenotype
# Organism	CXA5_HUMAN	Homo sapiens (Human)
# Orphanet	3303	Tetralogy of Fallot
# Orphanet	334	Familial atrial fibrillation
# PANTHER	PTHR11984	PTHR11984
# PANTHER	PTHR11984:SF13	PTHR11984:SF13
# PIR	I38429	I38429
# PRINTS	PR00206	CONNEXIN
# PRINTS	PR01135	CONNEXINA5
# PROSITE	PS00407	CONNEXINS_1
# PROSITE	PS00408	CONNEXINS_2
# Pfam	PF00029	Connexin
# Pfam	PF16791	Connexin40_C
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-190861	Gap junction assembly
# RecName	CXA5_HUMAN	Gap junction alpha-5 protein
# RefSeq	NP_005257	NM_005266.6
# RefSeq	NP_859054	NM_181703.3
# RefSeq	XP_005273008	XM_005272951.4
# RefSeq	XP_016856533	XM_017001044.1
# SIMILARITY	Belongs to the connexin family. Alpha-type (group II) subfamily. {ECO	0000305}.
# SMART	SM00037	CNX
# SMART	SM01089	Connexin_CCC
# SUBCELLULAR LOCATION	CXA5_HUMAN	Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. 
# SUBUNIT	CXA5_HUMAN	A connexon is composed of a hexamer of connexins. 
# UCSC	uc057kfi	human
# eggNOG	ENOG410IF3Z	Eukaryota
# eggNOG	ENOG410ZC96	LUCA
BLAST	swissprot:CXA5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CXA5_HUMAN
BioCyc	ZFISH:ENSG00000143140-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000143140-MONOMER
COXPRESdb	2702	http://coxpresdb.jp/data/gene/2702.shtml
CleanEx	HS_GJA5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GJA5
DOI	10.1006/jmcc.1994.1103	http://dx.doi.org/10.1006/jmcc.1994.1103
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1053/euhj.1999.1718	http://dx.doi.org/10.1053/euhj.1999.1718
DOI	10.1056/NEJMoa052800	http://dx.doi.org/10.1056/NEJMoa052800
DOI	10.1093/europace/euq274	http://dx.doi.org/10.1093/europace/euq274
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF151979	http://www.ebi.ac.uk/ena/data/view/AF151979
EMBL	AL365260	http://www.ebi.ac.uk/ena/data/view/AL365260
EMBL	AL365260	http://www.ebi.ac.uk/ena/data/view/AL365260
EMBL	BC013313	http://www.ebi.ac.uk/ena/data/view/BC013313
EMBL	BT019415	http://www.ebi.ac.uk/ena/data/view/BT019415
EMBL	BT019416	http://www.ebi.ac.uk/ena/data/view/BT019416
EMBL	L34954	http://www.ebi.ac.uk/ena/data/view/L34954
EMBL	U03486	http://www.ebi.ac.uk/ena/data/view/U03486
Ensembl	ENST00000579774	http://www.ensembl.org/id/ENST00000579774
Ensembl	ENST00000621517	http://www.ensembl.org/id/ENST00000621517
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005921	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005921
GO_component	GO:0005922	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005922
GO_component	GO:0014704	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014704
GO_component	GO:0042995	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042995
GO_function	GO:0055077	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055077
GO_function	GO:0086075	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086075
GO_function	GO:0086077	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086077
GO_process	GO:0001501	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001501
GO_process	GO:0001525	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001525
GO_process	GO:0003105	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003105
GO_process	GO:0003151	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003151
GO_process	GO:0003158	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003158
GO_process	GO:0003161	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003161
GO_process	GO:0003174	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003174
GO_process	GO:0003193	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003193
GO_process	GO:0003281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003281
GO_process	GO:0003283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003283
GO_process	GO:0003284	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003284
GO_process	GO:0003294	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003294
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0010643	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010643
GO_process	GO:0010652	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010652
GO_process	GO:0016264	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016264
GO_process	GO:0030326	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030326
GO_process	GO:0035050	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035050
GO_process	GO:0035922	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035922
GO_process	GO:0045776	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045776
GO_process	GO:0045907	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045907
GO_process	GO:0045909	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045909
GO_process	GO:0048844	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048844
GO_process	GO:0051259	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051259
GO_process	GO:0055117	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055117
GO_process	GO:0060307	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060307
GO_process	GO:0060371	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060371
GO_process	GO:0060373	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060373
GO_process	GO:0060412	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060412
GO_process	GO:0060413	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060413
GO_process	GO:0086005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086005
GO_process	GO:0086015	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086015
GO_process	GO:0086053	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086053
GO_process	GO:0086054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086054
GO_process	GO:0086064	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086064
GO_process	GO:0086091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086091
GO_process	GO:0098904	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098904
GO_process	GO:0098905	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098905
GO_process	GO:0098906	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098906
GO_process	GO:0098910	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098910
GO_process	GO:1900133	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900133
GO_process	GO:1900825	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900825
GO_process	GO:1990029	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990029
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0003013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003013
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0022607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607
GOslim_process	GO:0034330	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034330
GOslim_process	GO:0048646	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048646
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GeneCards	GJA5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GJA5
GeneID	2702	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2702
GeneTree	ENSGT00840000129674	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00840000129674
HGNC	HGNC:4279	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4279
HOGENOM	HOG000231127	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231127&db=HOGENOM6
HOVERGEN	HBG009576	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG009576&db=HOVERGEN
HPA	CAB013080	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB013080
InParanoid	P36382	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36382
IntAct	P36382	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36382*
InterPro	IPR000500	http://www.ebi.ac.uk/interpro/entry/IPR000500
InterPro	IPR002264	http://www.ebi.ac.uk/interpro/entry/IPR002264
InterPro	IPR013092	http://www.ebi.ac.uk/interpro/entry/IPR013092
InterPro	IPR017990	http://www.ebi.ac.uk/interpro/entry/IPR017990
InterPro	IPR019570	http://www.ebi.ac.uk/interpro/entry/IPR019570
InterPro	IPR031862	http://www.ebi.ac.uk/interpro/entry/IPR031862
Jabion	2702	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2702
KEGG_Disease	H00731	http://www.genome.jp/dbget-bin/www_bget?H00731
KEGG_Gene	hsa:2702	http://www.genome.jp/dbget-bin/www_bget?hsa:2702
KEGG_Orthology	KO:K07614	http://www.genome.jp/dbget-bin/www_bget?KO:K07614
MIM	108770	http://www.ncbi.nlm.nih.gov/omim/108770
MIM	121013	http://www.ncbi.nlm.nih.gov/omim/121013
MIM	614049	http://www.ncbi.nlm.nih.gov/omim/614049
MINT	MINT-1454178	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1454178
OMA	HKHSTVI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HKHSTVI
Orphanet	3303	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=3303
Orphanet	334	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=334
OrthoDB	EOG091G0FKH	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0FKH
PANTHER	PTHR11984	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11984
PANTHER	PTHR11984:SF13	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11984:SF13
PRINTS	PR00206	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00206
PRINTS	PR01135	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01135
PROSITE	PS00407	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00407
PROSITE	PS00408	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00408
PSORT	swissprot:CXA5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CXA5_HUMAN
PSORT-B	swissprot:CXA5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CXA5_HUMAN
PSORT2	swissprot:CXA5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CXA5_HUMAN
Pfam	PF00029	http://pfam.xfam.org/family/PF00029
Pfam	PF16791	http://pfam.xfam.org/family/PF16791
PharmGKB	PA28690	http://www.pharmgkb.org/do/serve?objId=PA28690&objCls=Gene
Phobius	swissprot:CXA5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CXA5_HUMAN
PhylomeDB	P36382	http://phylomedb.org/?seqid=P36382
ProteinModelPortal	P36382	http://www.proteinmodelportal.org/query/uniprot/P36382
PubMed	10581143	http://www.ncbi.nlm.nih.gov/pubmed/10581143
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	16790700	http://www.ncbi.nlm.nih.gov/pubmed/16790700
PubMed	20650941	http://www.ncbi.nlm.nih.gov/pubmed/20650941
PubMed	7966354	http://www.ncbi.nlm.nih.gov/pubmed/7966354
Reactome	R-HSA-190861	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-190861
RefSeq	NP_005257	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005257
RefSeq	NP_859054	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_859054
RefSeq	XP_005273008	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005273008
RefSeq	XP_016856533	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016856533
SMART	SM00037	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00037
SMART	SM01089	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01089
STRING	9606.ENSP00000271348	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000271348&targetmode=cogs
UCSC	uc057kfi	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc057kfi&org=rat
UniGene	Hs.447968	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.447968
UniProtKB	CXA5_HUMAN	http://www.uniprot.org/uniprot/CXA5_HUMAN
UniProtKB-AC	P36382	http://www.uniprot.org/uniprot/P36382
charge	swissprot:CXA5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CXA5_HUMAN
eggNOG	ENOG410IF3Z	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IF3Z
eggNOG	ENOG410ZC96	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZC96
epestfind	swissprot:CXA5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CXA5_HUMAN
garnier	swissprot:CXA5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CXA5_HUMAN
helixturnhelix	swissprot:CXA5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CXA5_HUMAN
hmoment	swissprot:CXA5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CXA5_HUMAN
iep	swissprot:CXA5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CXA5_HUMAN
inforesidue	swissprot:CXA5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CXA5_HUMAN
neXtProt	NX_P36382	http://www.nextprot.org/db/entry/NX_P36382
octanol	swissprot:CXA5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CXA5_HUMAN
pepcoil	swissprot:CXA5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CXA5_HUMAN
pepdigest	swissprot:CXA5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CXA5_HUMAN
pepinfo	swissprot:CXA5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CXA5_HUMAN
pepnet	swissprot:CXA5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CXA5_HUMAN
pepstats	swissprot:CXA5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CXA5_HUMAN
pepwheel	swissprot:CXA5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CXA5_HUMAN
pepwindow	swissprot:CXA5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CXA5_HUMAN
sigcleave	swissprot:CXA5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CXA5_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GPM6A_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P51674-1; Sequence=Displayed; Name=2; IsoId=P51674-2; Sequence=VSP_045109; Name=3; IsoId=P51674-3; Sequence=VSP_046098; Note=No experimental confirmation available.; 
# BioGrid	109084	33
# CCDS	CCDS3824	-. [P51674-1]
# CCDS	CCDS54822	-. [P51674-3]
# CCDS	CCDS58936	-. [P51674-2]
# ChiTaRS	GPM6A	human
# Ensembl	ENST00000280187	ENSP00000280187; ENSG00000150625. [P51674-1]
# Ensembl	ENST00000393658	ENSP00000377268; ENSG00000150625. [P51674-1]
# Ensembl	ENST00000506894	ENSP00000421578; ENSG00000150625. [P51674-3]
# Ensembl	ENST00000515090	ENSP00000423984; ENSG00000150625. [P51674-2]
# ExpressionAtlas	P51674	baseline and differential
# FUNCTION	GPM6A_HUMAN	Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G- protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor. {ECO 0000269|PubMed 19298174}. 
# GO_component	GO:0005886	plasma membrane; ISS:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0030175	filopodium; ISS:UniProtKB.
# GO_component	GO:0043005	neuron projection; ISS:UniProtKB.
# GO_component	GO:0043025	neuronal cell body; ISS:UniProtKB.
# GO_component	GO:0043197	dendritic spine; IEA:UniProtKB-SubCell.
# GO_component	GO:0044295	axonal growth cone; ISS:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_component	GO:1903561	extracellular vesicle; IDA:UniProtKB.
# GO_function	GO:0005262	calcium channel activity; IEA:Ensembl.
# GO_process	GO:0001764	neuron migration; IDA:UniProtKB.
# GO_process	GO:0003407	neural retina development; ISS:UniProtKB.
# GO_process	GO:0007416	synapse assembly; ISS:UniProtKB.
# GO_process	GO:0048812	neuron projection morphogenesis; ISS:UniProtKB.
# GO_process	GO:0048863	stem cell differentiation; IDA:UniProtKB.
# GO_process	GO:0051491	positive regulation of filopodium assembly; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0022607	cellular component assembly
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0048870	cell motility
# Genevisible	P51674	HS
# HGNC	HGNC:4460	GPM6A
# INTERACTION	GPM6A_HUMAN	Q8IUH5 ZDHHC17; NbExp=5; IntAct=EBI-7187133, EBI-524753; 
# IntAct	P51674	3
# InterPro	IPR001614	Myelin_PLP
# InterPro	IPR018237	Myelin_PLP_CS
# MIM	601275	gene
# Organism	GPM6A_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11683	PTHR11683
# PRINTS	PR00214	MYELINPLP
# PROSITE	PS00575	MYELIN_PLP_1
# PROSITE	PS01004	MYELIN_PLP_2
# Pfam	PF01275	Myelin_PLP
# Proteomes	UP000005640	Chromosome 4
# RecName	GPM6A_HUMAN	Neuronal membrane glycoprotein M6-a
# RefSeq	NP_001248377	NM_001261448.1. [P51674-2]
# RefSeq	NP_005268	NM_005277.4. [P51674-1]
# RefSeq	NP_963885	NM_201591.2. [P51674-1]
# RefSeq	NP_963886	NM_201592.2. [P51674-3]
# SIMILARITY	Belongs to the myelin proteolipid protein family. {ECO	0000305}.
# SMART	SM00002	PLP
# SUBCELLULAR LOCATION	GPM6A_HUMAN	Cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Cell projection, axon {ECO 0000250}. Cell projection, dendritic spine {ECO 0000250}. Cell projection, filopodium {ECO 0000250}. Note=Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons. Localized to plasma membrane of cell bodies and neurites of hippocampal neurons. Localized in membrane protrusions (filopodia and spines) of primary hippocampal neurons. Localized to the growth cone edge membrane of elongating axons (By similarity). {ECO 0000250}. 
# SUBUNIT	Interacts with OPRM1. {ECO	0000250}. 
# UCSC	uc003iuf	human. [P51674-1]
# eggNOG	ENOG4110EPW	LUCA
# eggNOG	KOG4800	Eukaryota
BLAST	swissprot:GPM6A_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GPM6A_HUMAN
BioCyc	ZFISH:ENSG00000150625-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000150625-MONOMER
COXPRESdb	2823	http://coxpresdb.jp/data/gene/2823.shtml
CleanEx	HS_GPM6A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GPM6A
DOI	10.1006/geno.1996.0231	http://dx.doi.org/10.1006/geno.1996.0231
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/mcp.M111.015131	http://dx.doi.org/10.1074/mcp.M111.015131
DOI	10.1089/scd.2008.0215	http://dx.doi.org/10.1089/scd.2008.0215
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC093819	http://www.ebi.ac.uk/ena/data/view/AC093819
EMBL	AC097537	http://www.ebi.ac.uk/ena/data/view/AC097537
EMBL	AC110794	http://www.ebi.ac.uk/ena/data/view/AC110794
EMBL	AK226176	http://www.ebi.ac.uk/ena/data/view/AK226176
EMBL	AK299788	http://www.ebi.ac.uk/ena/data/view/AK299788
EMBL	BC022508	http://www.ebi.ac.uk/ena/data/view/BC022508
EMBL	BC022528	http://www.ebi.ac.uk/ena/data/view/BC022528
EMBL	D49958	http://www.ebi.ac.uk/ena/data/view/D49958
EMBL	U45956	http://www.ebi.ac.uk/ena/data/view/U45956
Ensembl	ENST00000280187	http://www.ensembl.org/id/ENST00000280187
Ensembl	ENST00000393658	http://www.ensembl.org/id/ENST00000393658
Ensembl	ENST00000506894	http://www.ensembl.org/id/ENST00000506894
Ensembl	ENST00000515090	http://www.ensembl.org/id/ENST00000515090
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030175	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030175
GO_component	GO:0043005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043005
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0043197	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043197
GO_component	GO:0044295	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044295
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_component	GO:1903561	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903561
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_process	GO:0001764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001764
GO_process	GO:0003407	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003407
GO_process	GO:0007416	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007416
GO_process	GO:0048812	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048812
GO_process	GO:0048863	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048863
GO_process	GO:0051491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051491
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0022607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GeneCards	GPM6A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GPM6A
GeneID	2823	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2823
GeneTree	ENSGT00390000006915	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000006915
HGNC	HGNC:4460	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4460
HOGENOM	HOG000231338	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231338&db=HOGENOM6
HOVERGEN	HBG000096	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000096&db=HOVERGEN
HPA	HPA017338	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA017338
InParanoid	P51674	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P51674
IntAct	P51674	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P51674*
InterPro	IPR001614	http://www.ebi.ac.uk/interpro/entry/IPR001614
InterPro	IPR018237	http://www.ebi.ac.uk/interpro/entry/IPR018237
Jabion	2823	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2823
KEGG_Gene	hsa:2823	http://www.genome.jp/dbget-bin/www_bget?hsa:2823
MIM	601275	http://www.ncbi.nlm.nih.gov/omim/601275
OMA	EEKKVCT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EEKKVCT
OrthoDB	EOG091G0IM5	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0IM5
PANTHER	PTHR11683	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11683
PRINTS	PR00214	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00214
PROSITE	PS00575	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00575
PROSITE	PS01004	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01004
PSORT	swissprot:GPM6A_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GPM6A_HUMAN
PSORT-B	swissprot:GPM6A_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GPM6A_HUMAN
PSORT2	swissprot:GPM6A_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GPM6A_HUMAN
Pfam	PF01275	http://pfam.xfam.org/family/PF01275
PharmGKB	PA28843	http://www.pharmgkb.org/do/serve?objId=PA28843&objCls=Gene
Phobius	swissprot:GPM6A_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GPM6A_HUMAN
PhylomeDB	P51674	http://phylomedb.org/?seqid=P51674
ProteinModelPortal	P51674	http://www.proteinmodelportal.org/query/uniprot/P51674
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	19298174	http://www.ncbi.nlm.nih.gov/pubmed/19298174
PubMed	22223895	http://www.ncbi.nlm.nih.gov/pubmed/22223895
PubMed	8661015	http://www.ncbi.nlm.nih.gov/pubmed/8661015
PubMed	8893821	http://www.ncbi.nlm.nih.gov/pubmed/8893821
RefSeq	NP_001248377	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001248377
RefSeq	NP_005268	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005268
RefSeq	NP_963885	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_963885
RefSeq	NP_963886	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_963886
SMART	SM00002	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00002
STRING	9606.ENSP00000280187	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000280187&targetmode=cogs
UCSC	uc003iuf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003iuf&org=rat
UniGene	Hs.75819	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.75819
UniProtKB	GPM6A_HUMAN	http://www.uniprot.org/uniprot/GPM6A_HUMAN
UniProtKB-AC	P51674	http://www.uniprot.org/uniprot/P51674
charge	swissprot:GPM6A_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GPM6A_HUMAN
eggNOG	ENOG4110EPW	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110EPW
eggNOG	KOG4800	http://eggnogapi.embl.de/nog_data/html/tree/KOG4800
epestfind	swissprot:GPM6A_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GPM6A_HUMAN
garnier	swissprot:GPM6A_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GPM6A_HUMAN
helixturnhelix	swissprot:GPM6A_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GPM6A_HUMAN
hmoment	swissprot:GPM6A_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GPM6A_HUMAN
iep	swissprot:GPM6A_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GPM6A_HUMAN
inforesidue	swissprot:GPM6A_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GPM6A_HUMAN
neXtProt	NX_P51674	http://www.nextprot.org/db/entry/NX_P51674
octanol	swissprot:GPM6A_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GPM6A_HUMAN
pepcoil	swissprot:GPM6A_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GPM6A_HUMAN
pepdigest	swissprot:GPM6A_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GPM6A_HUMAN
pepinfo	swissprot:GPM6A_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GPM6A_HUMAN
pepnet	swissprot:GPM6A_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GPM6A_HUMAN
pepstats	swissprot:GPM6A_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GPM6A_HUMAN
pepwheel	swissprot:GPM6A_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GPM6A_HUMAN
pepwindow	swissprot:GPM6A_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GPM6A_HUMAN
sigcleave	swissprot:GPM6A_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GPM6A_HUMAN
## Database	ID	URL or Descriptions
# AltName	QCR1_HUMAN	Complex III subunit 1
# AltName	QCR1_HUMAN	Core protein I
# AltName	QCR1_HUMAN	Ubiquinol-cytochrome-c reductase complex core protein 1
# BioGrid	113230	53
# CAUTION	Does not seem to have a protease activity as it lack the zinc-binding site. {ECO	0000305}.
# ChiTaRS	UQCRC1	human
# Ensembl	ENST00000203407	ENSP00000203407; ENSG00000010256
# ExpressionAtlas	P31930	baseline and differential
# FUNCTION	QCR1_HUMAN	This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. 
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0005746	mitochondrial respiratory chain; TAS:ProtInc.
# GO_component	GO:0005750	mitochondrial respiratory chain complex III; IBA:GO_Central.
# GO_component	GO:0043209	myelin sheath; IEA:Ensembl.
# GO_function	GO:0004222	metalloendopeptidase activity; IBA:GO_Central.
# GO_function	GO:0008121	ubiquinol-cytochrome-c reductase activity; TAS:ProtInc.
# GO_function	GO:0008270	zinc ion binding; IBA:GO_Central.
# GO_function	GO:0031625	ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
# GO_process	GO:0006119	oxidative phosphorylation; TAS:ProtInc.
# GO_process	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c; IBA:GO_Central.
# GO_process	GO:0009060	aerobic respiration; TAS:ProtInc.
# GO_process	GO:0014823	response to activity; IEA:Ensembl.
# GO_process	GO:0016485	protein processing; IBA:GO_Central.
# GO_process	GO:0043279	response to alkaloid; IEA:Ensembl.
# GO_process	GO:0055114	oxidation-reduction process; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0008233	peptidase activity
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0051604	protein maturation
# Gene3D	3.30.830.10	-; 2.
# Genevisible	P31930	HS
# HGNC	HGNC:12585	UQCRC1
# IntAct	P31930	27
# InterPro	IPR007863	Peptidase_M16_C
# InterPro	IPR011237	Pept_M16_dom
# InterPro	IPR011249	Metalloenz_LuxS/M16
# InterPro	IPR011765	Pept_M16_N
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	191328	gene
# Organism	QCR1_HUMAN	Homo sapiens (Human)
# PIR	A48043	A48043
# Pfam	PF00675	Peptidase_M16
# Pfam	PF05193	Peptidase_M16_C
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-611105	Respiratory electron transport
# RecName	QCR1_HUMAN	Cytochrome b-c1 complex subunit 1, mitochondrial
# RefSeq	NP_003356	NM_003365.2
# SIMILARITY	Belongs to the peptidase M16 family. UQCRC1/QCR1 subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	QCR1_HUMAN	Mitochondrion inner membrane. 
# SUBUNIT	The bc1 complex contains 11 subunits	 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1). 
# SUPFAM	SSF63411	SSF63411; 2
# UCSC	uc003cub	human
# eggNOG	COG0612	LUCA
# eggNOG	KOG0960	Eukaryota
BLAST	swissprot:QCR1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:QCR1_HUMAN
BioCyc	ZFISH:HS00277-MONOMER	http://biocyc.org/getid?id=ZFISH:HS00277-MONOMER
COXPRESdb	7384	http://coxpresdb.jp/data/gene/7384.shtml
CleanEx	HS_UQCRC1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_UQCRC1
DOI	10.1002/elps.11501401181	http://dx.doi.org/10.1002/elps.11501401181
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1007/s004390050988	http://dx.doi.org/10.1007/s004390050988
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/BJ20040647	http://dx.doi.org/10.1042/BJ20040647
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AK313090	http://www.ebi.ac.uk/ena/data/view/AK313090
EMBL	BC009586	http://www.ebi.ac.uk/ena/data/view/BC009586
EMBL	CH471055	http://www.ebi.ac.uk/ena/data/view/CH471055
EMBL	D26485	http://www.ebi.ac.uk/ena/data/view/D26485
EMBL	L16842	http://www.ebi.ac.uk/ena/data/view/L16842
Ensembl	ENST00000203407	http://www.ensembl.org/id/ENST00000203407
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005746	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005746
GO_component	GO:0005750	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005750
GO_component	GO:0043209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043209
GO_function	GO:0004222	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004222
GO_function	GO:0008121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008121
GO_function	GO:0008270	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270
GO_function	GO:0031625	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031625
GO_process	GO:0006119	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006119
GO_process	GO:0006122	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006122
GO_process	GO:0009060	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009060
GO_process	GO:0014823	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014823
GO_process	GO:0016485	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016485
GO_process	GO:0043279	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043279
GO_process	GO:0055114	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0008233	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0051604	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604
Gene3D	3.30.830.10	http://www.cathdb.info/version/latest/superfamily/3.30.830.10
GeneCards	UQCRC1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=UQCRC1
GeneID	7384	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7384
GeneTree	ENSGT00550000074701	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074701
HGNC	HGNC:12585	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:12585
HOGENOM	HOG000242450	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000242450&db=HOGENOM6
HOVERGEN	HBG006393	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006393&db=HOVERGEN
HPA	CAB033782	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB033782
HPA	HPA002815	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA002815
HPA	HPA003525	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA003525
InParanoid	P31930	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31930
IntAct	P31930	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31930*
InterPro	IPR007863	http://www.ebi.ac.uk/interpro/entry/IPR007863
InterPro	IPR011237	http://www.ebi.ac.uk/interpro/entry/IPR011237
InterPro	IPR011249	http://www.ebi.ac.uk/interpro/entry/IPR011249
InterPro	IPR011765	http://www.ebi.ac.uk/interpro/entry/IPR011765
Jabion	7384	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7384
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Gene	hsa:7384	http://www.genome.jp/dbget-bin/www_bget?hsa:7384
KEGG_Orthology	KO:K00414	http://www.genome.jp/dbget-bin/www_bget?KO:K00414
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	191328	http://www.ncbi.nlm.nih.gov/omim/191328
MINT	MINT-3012677	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3012677
OMA	DDMMFFL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DDMMFFL
OrthoDB	EOG091G05W9	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05W9
PSORT	swissprot:QCR1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:QCR1_HUMAN
PSORT-B	swissprot:QCR1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:QCR1_HUMAN
PSORT2	swissprot:QCR1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:QCR1_HUMAN
Pfam	PF00675	http://pfam.xfam.org/family/PF00675
Pfam	PF05193	http://pfam.xfam.org/family/PF05193
PharmGKB	PA37216	http://www.pharmgkb.org/do/serve?objId=PA37216&objCls=Gene
Phobius	swissprot:QCR1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:QCR1_HUMAN
PhylomeDB	P31930	http://phylomedb.org/?seqid=P31930
ProteinModelPortal	P31930	http://www.proteinmodelportal.org/query/uniprot/P31930
PubMed	10453733	http://www.ncbi.nlm.nih.gov/pubmed/10453733
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15242332	http://www.ncbi.nlm.nih.gov/pubmed/15242332
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	7951059	http://www.ncbi.nlm.nih.gov/pubmed/7951059
PubMed	7981668	http://www.ncbi.nlm.nih.gov/pubmed/7981668
PubMed	8069229	http://www.ncbi.nlm.nih.gov/pubmed/8069229
PubMed	8313870	http://www.ncbi.nlm.nih.gov/pubmed/8313870
PubMed	8407948	http://www.ncbi.nlm.nih.gov/pubmed/8407948
Reactome	R-HSA-611105	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-611105
RefSeq	NP_003356	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003356
SMR	P31930	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31930
STRING	9606.ENSP00000203407	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000203407&targetmode=cogs
SUPFAM	SSF63411	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63411
SWISS-2DPAGE	P31930	http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P31930
UCSC	uc003cub	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003cub&org=rat
UniGene	Hs.119251	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.119251
UniProtKB	QCR1_HUMAN	http://www.uniprot.org/uniprot/QCR1_HUMAN
UniProtKB-AC	P31930	http://www.uniprot.org/uniprot/P31930
charge	swissprot:QCR1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:QCR1_HUMAN
eggNOG	COG0612	http://eggnogapi.embl.de/nog_data/html/tree/COG0612
eggNOG	KOG0960	http://eggnogapi.embl.de/nog_data/html/tree/KOG0960
epestfind	swissprot:QCR1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:QCR1_HUMAN
garnier	swissprot:QCR1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:QCR1_HUMAN
helixturnhelix	swissprot:QCR1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:QCR1_HUMAN
hmoment	swissprot:QCR1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:QCR1_HUMAN
iep	swissprot:QCR1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:QCR1_HUMAN
inforesidue	swissprot:QCR1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:QCR1_HUMAN
neXtProt	NX_P31930	http://www.nextprot.org/db/entry/NX_P31930
octanol	swissprot:QCR1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:QCR1_HUMAN
pepcoil	swissprot:QCR1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:QCR1_HUMAN
pepdigest	swissprot:QCR1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:QCR1_HUMAN
pepinfo	swissprot:QCR1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:QCR1_HUMAN
pepnet	swissprot:QCR1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:QCR1_HUMAN
pepstats	swissprot:QCR1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:QCR1_HUMAN
pepwheel	swissprot:QCR1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:QCR1_HUMAN
pepwindow	swissprot:QCR1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:QCR1_HUMAN
sigcleave	swissprot:QCR1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:QCR1_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	116636	7
# CDD	cd06174	MFS
# ChiTaRS	SV2C	human
# Ensembl	ENST00000502798	ENSP00000423541; ENSG00000122012
# ExpressionAtlas	Q496J9	baseline and differential
# FUNCTION	SV2C_HUMAN	Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity). {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008021	synaptic vesicle; TAS:ParkinsonsUK-UCL.
# GO_component	GO:0016021	integral component of membrane; IBA:GO_Central.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030672	synaptic vesicle membrane; IBA:GO_Central.
# GO_component	GO:0043005	neuron projection; IBA:GO_Central.
# GO_function	GO:0022857	transmembrane transporter activity; IEA:InterPro.
# GO_process	GO:0001504	neurotransmitter uptake; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q496J9	HS
# HGNC	HGNC:30670	SV2C
# InterPro	IPR001646	5peptide_repeat
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR005829	Sugar_transporter_CS
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# InterPro	IPR022308	SV2
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko04512	ECM-receptor interaction
# MIM	610291	gene
# Organism	SV2C_HUMAN	Homo sapiens (Human)
# PDB	4JRA	X-ray; 2.30 A; C/D=456-574
# PDB	5JLV	X-ray; 2.00 A; C/D=473-567
# PROSITE	PS50850	MFS
# PTM	SV2C_HUMAN	N-glycosylated. {ECO 0000250}. 
# Pfam	PF00083	Sugar_tr
# Pfam	PF07690	MFS_1
# Pfam	PF13599	Pentapeptide_4
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-5250955	Toxicity of botulinum toxin type D (BoNT/D)
# Reactome	R-HSA-5250968	Toxicity of botulinum toxin type A (BoNT/A)
# Reactome	R-HSA-5250981	Toxicity of botulinum toxin type F (BoNT/F)
# RecName	SV2C_HUMAN	Synaptic vesicle glycoprotein 2C
# RefSeq	NP_055794	NM_014979.3
# RefSeq	XP_011541583	XM_011543281.2
# RefSeq	XP_011541584	XM_011543282.2
# SIMILARITY	Belongs to the major facilitator superfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	SV2C_HUMAN	Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Note=Enriched in small synaptic vesicles and adrenal microsomes, not present in chromaffin granules. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas (By similarity). {ECO 0000250}. 
# SUBUNIT	Interacts with SYT1 in a calcium-dependent manner. {ECO	0000250}. 
# SUPFAM	SSF103473	SSF103473; 3
# TIGRFAMs	TIGR01299	synapt_SV2
# UCSC	uc003kei	human
# eggNOG	ENOG410YQME	LUCA
# eggNOG	KOG0255	Eukaryota
BLAST	swissprot:SV2C_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SV2C_HUMAN
COXPRESdb	22987	http://coxpresdb.jp/data/gene/22987.shtml
CleanEx	HS_SV2C	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SV2C
DIP	DIP-60687N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-60687N
DOI	10.1093/dnares/6.3.197	http://dx.doi.org/10.1093/dnares/6.3.197
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB028977	http://www.ebi.ac.uk/ena/data/view/AB028977
EMBL	BC100824	http://www.ebi.ac.uk/ena/data/view/BC100824
EMBL	BC100825	http://www.ebi.ac.uk/ena/data/view/BC100825
EMBL	BC100826	http://www.ebi.ac.uk/ena/data/view/BC100826
EMBL	BC100827	http://www.ebi.ac.uk/ena/data/view/BC100827
Ensembl	ENST00000502798	http://www.ensembl.org/id/ENST00000502798
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008021
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030672	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030672
GO_component	GO:0043005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043005
GO_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GO_process	GO:0001504	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001504
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SV2C	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SV2C
GeneID	22987	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22987
GeneTree	ENSGT00550000074384	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074384
HGNC	HGNC:30670	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:30670
HOGENOM	HOG000065727	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000065727&db=HOGENOM6
HOVERGEN	HBG053967	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053967&db=HOVERGEN
HPA	HPA040722	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA040722
HPA	HPA040770	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA040770
InParanoid	Q496J9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q496J9
InterPro	IPR001646	http://www.ebi.ac.uk/interpro/entry/IPR001646
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR005829	http://www.ebi.ac.uk/interpro/entry/IPR005829
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
InterPro	IPR022308	http://www.ebi.ac.uk/interpro/entry/IPR022308
Jabion	22987	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=22987
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:22987	http://www.genome.jp/dbget-bin/www_bget?hsa:22987
KEGG_Orthology	KO:K06258	http://www.genome.jp/dbget-bin/www_bget?KO:K06258
KEGG_Pathway	ko04512	http://www.genome.jp/kegg-bin/show_pathway?ko04512
MIM	610291	http://www.ncbi.nlm.nih.gov/omim/610291
OMA	DFEPYKF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DFEPYKF
OrthoDB	EOG091G02NC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02NC
PDB	4JRA	http://www.ebi.ac.uk/pdbe-srv/view/entry/4JRA
PDB	5JLV	http://www.ebi.ac.uk/pdbe-srv/view/entry/5JLV
PDBsum	4JRA	http://www.ebi.ac.uk/pdbsum/4JRA
PDBsum	5JLV	http://www.ebi.ac.uk/pdbsum/5JLV
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:SV2C_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SV2C_HUMAN
PSORT-B	swissprot:SV2C_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SV2C_HUMAN
PSORT2	swissprot:SV2C_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SV2C_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
Pfam	PF13599	http://pfam.xfam.org/family/PF13599
PharmGKB	PA25005	http://www.pharmgkb.org/do/serve?objId=PA25005&objCls=Gene
Phobius	swissprot:SV2C_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SV2C_HUMAN
PhylomeDB	Q496J9	http://phylomedb.org/?seqid=Q496J9
ProteinModelPortal	Q496J9	http://www.proteinmodelportal.org/query/uniprot/Q496J9
PubMed	10470851	http://www.ncbi.nlm.nih.gov/pubmed/10470851
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-5250955	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5250955
Reactome	R-HSA-5250968	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5250968
Reactome	R-HSA-5250981	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5250981
RefSeq	NP_055794	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055794
RefSeq	XP_011541583	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011541583
RefSeq	XP_011541584	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011541584
SMR	Q496J9	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q496J9
STRING	9606.ENSP00000423541	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000423541&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TIGRFAMs	TIGR01299	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01299
UCSC	uc003kei	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003kei&org=rat
UniGene	Hs.646953	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.646953
UniGene	Hs.663229	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.663229
UniProtKB	SV2C_HUMAN	http://www.uniprot.org/uniprot/SV2C_HUMAN
UniProtKB-AC	Q496J9	http://www.uniprot.org/uniprot/Q496J9
charge	swissprot:SV2C_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SV2C_HUMAN
eggNOG	ENOG410YQME	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YQME
eggNOG	KOG0255	http://eggnogapi.embl.de/nog_data/html/tree/KOG0255
epestfind	swissprot:SV2C_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SV2C_HUMAN
garnier	swissprot:SV2C_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SV2C_HUMAN
helixturnhelix	swissprot:SV2C_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SV2C_HUMAN
hmoment	swissprot:SV2C_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SV2C_HUMAN
iep	swissprot:SV2C_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SV2C_HUMAN
inforesidue	swissprot:SV2C_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SV2C_HUMAN
neXtProt	NX_Q496J9	http://www.nextprot.org/db/entry/NX_Q496J9
octanol	swissprot:SV2C_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SV2C_HUMAN
pepcoil	swissprot:SV2C_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SV2C_HUMAN
pepdigest	swissprot:SV2C_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SV2C_HUMAN
pepinfo	swissprot:SV2C_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SV2C_HUMAN
pepnet	swissprot:SV2C_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SV2C_HUMAN
pepstats	swissprot:SV2C_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SV2C_HUMAN
pepwheel	swissprot:SV2C_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SV2C_HUMAN
pepwindow	swissprot:SV2C_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SV2C_HUMAN
sigcleave	swissprot:SV2C_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SV2C_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SC5A2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P31639-1; Sequence=Displayed; Name=2; IsoId=P31639-2; Sequence=VSP_056333, VSP_056334; Note=No experimental confirmation available.; 
# AltName	SC5A2_HUMAN	Low affinity sodium-glucose cotransporter
# AltName	SC5A2_HUMAN	Solute carrier family 5 member 2
# CCDS	CCDS10714	-. [P31639-1]
# ChiTaRS	SLC5A2	human
# DISEASE	SC5A2_HUMAN	Renal glucosuria (GLYS) [MIM 233100]  A disorder characterized by persistent isolated glucosuria, normal fasting serum glucose concentration, decreased renal tubular resorption of glucose from the urine, and absence of any other signs of tubular dysfunction. {ECO 0000269|PubMed 14614622}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB06292	Dapagliflozin
# DrugBank	DB08907	Canagliflozin
# DrugBank	DB09038	Empagliflozin
# Ensembl	ENST00000330498	ENSP00000327943; ENSG00000140675. [P31639-1]
# Ensembl	ENST00000419665	ENSP00000410601; ENSG00000140675. [P31639-2]
# ExpressionAtlas	P31639	baseline and differential
# FUNCTION	SC5A2_HUMAN	Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. 
# FUNCTION	SC5A2_HUMAN	Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1 1. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	SC5A2_HUMAN	GO 0005362 low-affinity glucose sodium symporter activity; TAS ProtInc.
# GO_function	SC5A2_HUMAN	GO 0005412 glucose sodium symporter activity; TAS Reactome.
# GO_process	GO:0005975	carbohydrate metabolic process; TAS:ProtInc.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0005975	carbohydrate metabolic process
# GOslim_process	GO:0006810	transport
# Genevisible	P31639	HS
# HGNC	HGNC:11037	SLC5A2
# InterPro	IPR001734	Na/solute_symporter
# InterPro	IPR018212	Na/solute_symporter_CS
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H01126	[Urinary system disease; Inherited metabolic disease] Familial renal glucosuria (FRG)
# MIM	182381	gene
# MIM	233100	phenotype
# Organism	SC5A2_HUMAN	Homo sapiens (Human)
# Orphanet	69076	Renal glucosuria
# PANTHER	PTHR11819	PTHR11819; 2
# PIR	A56765	A56765
# PROSITE	PS00456	NA_SOLUT_SYMP_1
# PROSITE	PS00457	NA_SOLUT_SYMP_2
# PROSITE	PS50283	NA_SOLUT_SYMP_3
# Pfam	PF00474	SSF
# Proteomes	UP000005640	Chromosome 16
# Reactome	R-HSA-189200	Hexose transport
# Reactome	R-HSA-428808	Na+-dependent glucose transporters
# Reactome	R-HSA-429593	Inositol transporters
# RecName	SC5A2_HUMAN	Sodium/glucose cotransporter 2
# RefSeq	NP_003032	NM_003041.3. [P31639-1]
# SIMILARITY	Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	SC5A2_HUMAN	Membrane; Multi-pass membrane protein. 
# TCDB	2.A.21.3.16:the solute	sodium symporter (sss) family
# TIGRFAMs	TIGR00813	sss
# UCSC	uc002ecf	human. [P31639-1]
# eggNOG	COG4146	LUCA
# eggNOG	ENOG410IP49	Eukaryota
BLAST	swissprot:SC5A2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SC5A2_HUMAN
BioCyc	ZFISH:ENSG00000140675-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000140675-MONOMER
COXPRESdb	6524	http://coxpresdb.jp/data/gene/6524.shtml
CleanEx	HS_SLC5A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC5A2
DOI	10.1007/s00439-003-1054-x	http://dx.doi.org/10.1007/s00439-003-1054-x
DOI	10.1038/nature03187	http://dx.doi.org/10.1038/nature03187
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB06292	http://www.drugbank.ca/drugs/DB06292
DrugBank	DB08907	http://www.drugbank.ca/drugs/DB08907
DrugBank	DB09038	http://www.drugbank.ca/drugs/DB09038
EMBL	AC026471	http://www.ebi.ac.uk/ena/data/view/AC026471
EMBL	BC131542	http://www.ebi.ac.uk/ena/data/view/BC131542
EMBL	M95549	http://www.ebi.ac.uk/ena/data/view/M95549
Ensembl	ENST00000330498	http://www.ensembl.org/id/ENST00000330498
Ensembl	ENST00000419665	http://www.ensembl.org/id/ENST00000419665
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005362	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005362
GO_function	GO:0005412	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005412
GO_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC5A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC5A2
GeneID	6524	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6524
GeneTree	ENSGT00760000118955	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118955
HGNC	HGNC:11037	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11037
HOGENOM	HOG000025422	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000025422&db=HOGENOM6
HOVERGEN	HBG052859	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052859&db=HOVERGEN
HPA	HPA041603	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA041603
InParanoid	P31639	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31639
InterPro	IPR001734	http://www.ebi.ac.uk/interpro/entry/IPR001734
InterPro	IPR018212	http://www.ebi.ac.uk/interpro/entry/IPR018212
Jabion	6524	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6524
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H01126	http://www.genome.jp/dbget-bin/www_bget?H01126
KEGG_Gene	hsa:6524	http://www.genome.jp/dbget-bin/www_bget?hsa:6524
KEGG_Orthology	KO:K14382	http://www.genome.jp/dbget-bin/www_bget?KO:K14382
MIM	182381	http://www.ncbi.nlm.nih.gov/omim/182381
MIM	233100	http://www.ncbi.nlm.nih.gov/omim/233100
OMA	CTAPIPR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CTAPIPR
Orphanet	69076	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=69076
OrthoDB	EOG091G077U	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G077U
PANTHER	PTHR11819	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11819
PROSITE	PS00456	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00456
PROSITE	PS00457	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00457
PROSITE	PS50283	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50283
PSORT	swissprot:SC5A2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SC5A2_HUMAN
PSORT-B	swissprot:SC5A2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SC5A2_HUMAN
PSORT2	swissprot:SC5A2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SC5A2_HUMAN
Pfam	PF00474	http://pfam.xfam.org/family/PF00474
PharmGKB	PA35902	http://www.pharmgkb.org/do/serve?objId=PA35902&objCls=Gene
Phobius	swissprot:SC5A2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SC5A2_HUMAN
PhylomeDB	P31639	http://phylomedb.org/?seqid=P31639
ProteinModelPortal	P31639	http://www.proteinmodelportal.org/query/uniprot/P31639
PubMed	1415574	http://www.ncbi.nlm.nih.gov/pubmed/1415574
PubMed	14614622	http://www.ncbi.nlm.nih.gov/pubmed/14614622
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15616553	http://www.ncbi.nlm.nih.gov/pubmed/15616553
Reactome	R-HSA-189200	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-189200
Reactome	R-HSA-428808	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428808
Reactome	R-HSA-429593	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-429593
RefSeq	NP_003032	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003032
STRING	9606.ENSP00000327943	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000327943&targetmode=cogs
TCDB	2.A.21.3.16	http://www.tcdb.org/search/result.php?tc=2.A.21.3.16
TIGRFAMs	TIGR00813	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00813
UCSC	uc002ecf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ecf&org=rat
UniGene	Hs.709195	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.709195
UniProtKB	SC5A2_HUMAN	http://www.uniprot.org/uniprot/SC5A2_HUMAN
UniProtKB-AC	P31639	http://www.uniprot.org/uniprot/P31639
charge	swissprot:SC5A2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SC5A2_HUMAN
eggNOG	COG4146	http://eggnogapi.embl.de/nog_data/html/tree/COG4146
eggNOG	ENOG410IP49	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IP49
epestfind	swissprot:SC5A2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SC5A2_HUMAN
garnier	swissprot:SC5A2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SC5A2_HUMAN
helixturnhelix	swissprot:SC5A2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SC5A2_HUMAN
hmoment	swissprot:SC5A2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SC5A2_HUMAN
iep	swissprot:SC5A2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SC5A2_HUMAN
inforesidue	swissprot:SC5A2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SC5A2_HUMAN
neXtProt	NX_P31639	http://www.nextprot.org/db/entry/NX_P31639
octanol	swissprot:SC5A2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SC5A2_HUMAN
pepcoil	swissprot:SC5A2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SC5A2_HUMAN
pepdigest	swissprot:SC5A2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SC5A2_HUMAN
pepinfo	swissprot:SC5A2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SC5A2_HUMAN
pepnet	swissprot:SC5A2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SC5A2_HUMAN
pepstats	swissprot:SC5A2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SC5A2_HUMAN
pepwheel	swissprot:SC5A2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SC5A2_HUMAN
pepwindow	swissprot:SC5A2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SC5A2_HUMAN
sigcleave	swissprot:SC5A2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SC5A2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ZNT2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BRI3-1; Sequence=Displayed; Name=2; IsoId=Q9BRI3-2; Sequence=VSP_039754; 
# AltName	ZNT2_HUMAN	Solute carrier family 30 member 2
# BioGrid	113561	7
# CCDS	CCDS272	-. [Q9BRI3-1]
# CCDS	CCDS30644	-. [Q9BRI3-2]
# DISEASE	ZNT2_HUMAN	Zinc deficiency, transient neonatal (TNZD) [MIM 608118]  A disorder occurring in breast-fed infants as a consequence of low milk zinc concentration in their nursing mothers, which cannot be corrected by maternal zinc supplementation. A large amount of zinc, an essential trace mineral, is required for normal growth particularly in infants, and breast milk normally contains adequate zinc to meet the requirement for infants up to 4 to 6 months of age. Zinc deficiency can lead to dermatitis, alopecia, decreased growth, and impaired immune function. The disorder shows autosomal dominant inheritance with incomplete penetrance. {ECO 0000269|PubMed 17065149, ECO 0000269|PubMed 22733820}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000374276	ENSP00000363394; ENSG00000158014. [Q9BRI3-2]
# Ensembl	ENST00000374278	ENSP00000363396; ENSG00000158014. [Q9BRI3-1]
# GO_component	GO:0005737	cytoplasm; IDA:BHF-UCL.
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005770	late endosome; IDA:BHF-UCL.
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0016023	cytoplasmic, membrane-bounded vesicle; IBA:GO_Central.
# GO_function	GO:0005385	zinc ion transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0010043	response to zinc ion; IBA:GO_Central.
# GO_process	GO:0061090	positive regulation of sequestering of zinc ion; IDA:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.20.1510.10	-; 1.
# Genevisible	Q9BRI3	HS
# HGNC	HGNC:11013	SLC30A2
# INTERACTION	ZNT2_HUMAN	Q08AM2 ADAM33; NbExp=5; IntAct=EBI-8644112, EBI-10225815; Q9BZ11-2 ADAM33; NbExp=3; IntAct=EBI-8644112, EBI-10303054; Q8N6L0 CCDC155; NbExp=5; IntAct=EBI-8644112, EBI-749265; P13236 CCL4; NbExp=5; IntAct=EBI-8644112, EBI-2873970; Q8NHW4 CCL4L2; NbExp=3; IntAct=EBI-8644112, EBI-10271156; P15151 PVR; NbExp=3; IntAct=EBI-8644112, EBI-3919694; Q9NP84 TNFRSF12A; NbExp=5; IntAct=EBI-8644112, EBI-2851995; 
# IntAct	Q9BRI3	14
# InterPro	IPR002524	Cation_efflux
# InterPro	IPR027469	Cation_efflux_TMD
# KEGG_Brite	ko02001	Solute carrier family
# MIM	608118	phenotype
# MIM	609617	gene
# Organism	ZNT2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11562	PTHR11562
# Pfam	PF01545	Cation_efflux
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-435368	Zinc efflux and compartmentalization by the SLC30 family
# RecName	ZNT2_HUMAN	Zinc transporter 2
# RefSeq	NP_001004434	NM_001004434.2. [Q9BRI3-2]
# RefSeq	NP_115902	NM_032513.4. [Q9BRI3-1]
# SIMILARITY	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	ZNT2_HUMAN	Isoform 2  Lysosome membrane. 
# SUBCELLULAR LOCATION	ZNT2_HUMAN	Vacuole membrane {ECO 0000269|PubMed 17897319}; Multi-pass membrane protein {ECO 0000269|PubMed 17897319}. 
# SUBUNIT	Homodimer. {ECO:0000269|PubMed	22733820}. 
# TCDB	2.A.4.3	the cation diffusion facilitator (cdf) family
# TIGRFAMs	TIGR01297	CDF
# UCSC	uc001blg	human. [Q9BRI3-1]
BLAST	swissprot:ZNT2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ZNT2_HUMAN
BioCyc	ZFISH:ENSG00000158014-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000158014-MONOMER
COXPRESdb	7780	http://coxpresdb.jp/data/gene/7780.shtml
CleanEx	HS_SLC30A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC30A2
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1073/pnas.0404089101	http://dx.doi.org/10.1073/pnas.0404089101
DOI	10.1074/jbc.M112.368159	http://dx.doi.org/10.1074/jbc.M112.368159
DOI	10.1074/jbc.M605821200	http://dx.doi.org/10.1074/jbc.M605821200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1600-0854.2007.00643.x	http://dx.doi.org/10.1111/j.1600-0854.2007.00643.x
EMBL	AF370409	http://www.ebi.ac.uk/ena/data/view/AF370409
EMBL	AL391650	http://www.ebi.ac.uk/ena/data/view/AL391650
EMBL	AL391650	http://www.ebi.ac.uk/ena/data/view/AL391650
EMBL	BC006251	http://www.ebi.ac.uk/ena/data/view/BC006251
Ensembl	ENST00000374276	http://www.ensembl.org/id/ENST00000374276
Ensembl	ENST00000374278	http://www.ensembl.org/id/ENST00000374278
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005770	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005770
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016023	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016023
GO_function	GO:0005385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005385
GO_process	GO:0010043	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010043
GO_process	GO:0061090	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061090
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.20.1510.10	http://www.cathdb.info/version/latest/superfamily/1.20.1510.10
GeneCards	SLC30A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC30A2
GeneID	7780	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7780
GeneTree	ENSGT00550000074381	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074381
HGNC	HGNC:11013	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11013
HOGENOM	HOG000079023	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000079023&db=HOGENOM6
HOVERGEN	HBG003345	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003345&db=HOVERGEN
HPA	HPA017979	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA017979
InParanoid	Q9BRI3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9BRI3
IntAct	Q9BRI3	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9BRI3*
InterPro	IPR002524	http://www.ebi.ac.uk/interpro/entry/IPR002524
InterPro	IPR027469	http://www.ebi.ac.uk/interpro/entry/IPR027469
Jabion	7780	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7780
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:7780	http://www.genome.jp/dbget-bin/www_bget?hsa:7780
KEGG_Orthology	KO:K14689	http://www.genome.jp/dbget-bin/www_bget?KO:K14689
MIM	608118	http://www.ncbi.nlm.nih.gov/omim/608118
MIM	609617	http://www.ncbi.nlm.nih.gov/omim/609617
OMA	MMIPRAI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MMIPRAI
OrthoDB	EOG091G07UN	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07UN
PANTHER	PTHR11562	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11562
PSORT	swissprot:ZNT2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ZNT2_HUMAN
PSORT-B	swissprot:ZNT2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ZNT2_HUMAN
PSORT2	swissprot:ZNT2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ZNT2_HUMAN
Pfam	PF01545	http://pfam.xfam.org/family/PF01545
PharmGKB	PA35883	http://www.pharmgkb.org/do/serve?objId=PA35883&objCls=Gene
Phobius	swissprot:ZNT2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ZNT2_HUMAN
PhylomeDB	Q9BRI3	http://phylomedb.org/?seqid=Q9BRI3
ProteinModelPortal	Q9BRI3	http://www.proteinmodelportal.org/query/uniprot/Q9BRI3
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15498874	http://www.ncbi.nlm.nih.gov/pubmed/15498874
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17065149	http://www.ncbi.nlm.nih.gov/pubmed/17065149
PubMed	17897319	http://www.ncbi.nlm.nih.gov/pubmed/17897319
PubMed	22733820	http://www.ncbi.nlm.nih.gov/pubmed/22733820
Reactome	R-HSA-435368	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-435368
RefSeq	NP_001004434	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001004434
RefSeq	NP_115902	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_115902
TCDB	2.A.4.3	http://www.tcdb.org/search/result.php?tc=2.A.4.3
TIGRFAMs	TIGR01297	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01297
UCSC	uc001blg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001blg&org=rat
UniGene	Hs.143545	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.143545
UniProtKB	ZNT2_HUMAN	http://www.uniprot.org/uniprot/ZNT2_HUMAN
UniProtKB-AC	Q9BRI3	http://www.uniprot.org/uniprot/Q9BRI3
charge	swissprot:ZNT2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ZNT2_HUMAN
epestfind	swissprot:ZNT2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ZNT2_HUMAN
garnier	swissprot:ZNT2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ZNT2_HUMAN
helixturnhelix	swissprot:ZNT2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZNT2_HUMAN
hmoment	swissprot:ZNT2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ZNT2_HUMAN
iep	swissprot:ZNT2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ZNT2_HUMAN
inforesidue	swissprot:ZNT2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ZNT2_HUMAN
neXtProt	NX_Q9BRI3	http://www.nextprot.org/db/entry/NX_Q9BRI3
octanol	swissprot:ZNT2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ZNT2_HUMAN
pepcoil	swissprot:ZNT2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ZNT2_HUMAN
pepdigest	swissprot:ZNT2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ZNT2_HUMAN
pepinfo	swissprot:ZNT2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ZNT2_HUMAN
pepnet	swissprot:ZNT2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ZNT2_HUMAN
pepstats	swissprot:ZNT2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ZNT2_HUMAN
pepwheel	swissprot:ZNT2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ZNT2_HUMAN
pepwindow	swissprot:ZNT2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ZNT2_HUMAN
sigcleave	swissprot:ZNT2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ZNT2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	PK1L2_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q7Z442-1; Sequence=Displayed; Name=2; Synonyms=Long isoform; IsoId=Q7Z442-2; Sequence=VSP_031942; Name=3; IsoId=Q7Z442-3; Sequence=VSP_031946, VSP_031948; Name=4; IsoId=Q7Z442-4; Sequence=VSP_031942, VSP_031946, VSP_031948; Note=No experimental confirmation available.; Name=6; IsoId=Q7Z442-6; Sequence=VSP_031942, VSP_031944, VSP_031945, VSP_031947; Note=No experimental confirmation available.; 
# AltName	PK1L2_HUMAN	PC1-like 2 protein
# AltName	PK1L2_HUMAN	Polycystin-1L2
# CCDS	CCDS61999	-. [Q7Z442-4]
# DEVELOPMENTAL STAGE	PK1L2_HUMAN	Expressed in fetal heart. 
# Ensembl	ENST00000337114	ENSP00000337397; ENSG00000166473. [Q7Z442-3]
# Ensembl	ENST00000527937	ENSP00000432818; ENSG00000166473. [Q7Z442-6]
# Ensembl	ENST00000531391	ENSP00000436309; ENSG00000166473. [Q7Z442-4]
# ExpressionAtlas	Q7Z442	baseline and differential
# FUNCTION	PK1L2_HUMAN	May function as an ion-channel regulator. May function as a G-protein-coupled receptor. {ECO 0000269|PubMed 15203210}. 
# GO_component	GO:0016020	membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005262	calcium channel activity; IBA:GO_Central.
# GO_function	GO:0005509	calcium ion binding; IEA:InterPro.
# GO_function	GO:0030246	carbohydrate binding; IEA:UniProtKB-KW.
# GO_process	GO:0050982	detection of mechanical stimulus; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0008150	biological_process
# Gene3D	2.60.60.20	-; 1.
# Gene3D	3.10.100.10	-; 1.
# Genevisible	Q7Z442	HS
# HGNC	HGNC:21715	PKD1L2
# InterPro	IPR000203	GPS
# InterPro	IPR000922	Lectin_gal-bd_dom
# InterPro	IPR001024	PLAT/LH2_dom
# InterPro	IPR001304	C-type_lectin-like
# InterPro	IPR002859	PKD/REJ-like
# InterPro	IPR003915	PKD_2
# InterPro	IPR013122	PKD1_2_channel
# InterPro	IPR014010	REJ_dom
# InterPro	IPR016186	C-type_lectin-like/link
# InterPro	IPR016187	CTDL_fold
# KEGG_Brite	ko04040	Ion channels
# MIM	607894	gene
# Organism	PK1L2_HUMAN	Homo sapiens (Human)
# PRINTS	PR01433	POLYCYSTIN2
# PROSITE	PS50041	C_TYPE_LECTIN_2
# PROSITE	PS50095	PLAT
# PROSITE	PS50221	GPS
# PROSITE	PS50228	SUEL_LECTIN
# PROSITE	PS51111	REJ
# Pfam	PF00059	Lectin_C
# Pfam	PF01477	PLAT
# Pfam	PF01825	GPS
# Pfam	PF02010	REJ
# Pfam	PF02140	Gal_Lectin
# Pfam	PF08016	PKD_channel
# Proteomes	UP000005640	Chromosome 16
# RecName	PK1L2_HUMAN	Polycystic kidney disease protein 1-like 2
# RefSeq	NP_001070248	NM_001076780.1. [Q7Z442-3]
# RefSeq	NP_001265352	NM_001278423.1. [Q7Z442-4]
# RefSeq	NP_001265354	NM_001278425.1
# RefSeq	NP_443124	NM_052892.3
# SEQUENCE CAUTION	PK1L2_HUMAN	Sequence=AAQ73173.1; Type=Frameshift; Positions=2113, 2117; Evidence={ECO 0000305}; Sequence=BAB67772.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO 0000305}; Sequence=BAC05222.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=BAD18529.1; Type=Erroneous translation; Note=Wrong CDS prediction.; Evidence={ECO 0000305};
# SIMILARITY	Belongs to the polycystin family. {ECO	0000305}. 
# SIMILARITY	Contains 1 C-type lectin domain. {ECO:0000255|PROSITE- ProRule	PRU00040}. 
# SIMILARITY	Contains 1 GPS domain. {ECO:0000255|PROSITE- ProRule	PRU00098}. 
# SIMILARITY	Contains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule	PRU00152}. 
# SIMILARITY	Contains 1 REJ domain. {ECO:0000255|PROSITE- ProRule	PRU00511}. 
# SIMILARITY	Contains 1 SUEL-type lectin domain. {ECO:0000255|PROSITE-ProRule	PRU00260}. 
# SMART	SM00034	CLECT
# SMART	SM00303	GPS
# SMART	SM00308	LH2
# SUBCELLULAR LOCATION	PK1L2_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUBUNIT	May interact via its C-terminus with GNAS and GNAI1. {ECO:0000269|PubMed	15203210}. 
# SUPFAM	SSF49723	SSF49723
# SUPFAM	SSF56436	SSF56436
# TISSUE SPECIFICITY	Expressed in all tissues tested including brain, placenta, mammary gland, testis, lung and liver. Highest expression in skeletal muscle. Isoform 2 is expressed in heart and kidney. {ECO:0000269|PubMed	12782129}. 
# UCSC	uc002fgi	human. [Q7Z442-1]
# eggNOG	ENOG410JFZI	Eukaryota
# eggNOG	ENOG410Z7Z0	LUCA
BLAST	swissprot:PK1L2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:PK1L2_HUMAN
BioCyc	ZFISH:ENSG00000140908-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000140908-MONOMER
COXPRESdb	114780	http://coxpresdb.jp/data/gene/114780.shtml
CleanEx	HS_PKD1L2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_PKD1L2
DOI	10.1016/S0888-7543(03)00048-X	http://dx.doi.org/10.1016/S0888-7543(03)00048-X
DOI	10.1016/j.ygeno.2004.02.008	http://dx.doi.org/10.1016/j.ygeno.2004.02.008
DOI	10.1038/nature03187	http://dx.doi.org/10.1038/nature03187
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/dnares/8.4.179	http://dx.doi.org/10.1093/dnares/8.4.179
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB067466	http://www.ebi.ac.uk/ena/data/view/AB067466
EMBL	AC092718	http://www.ebi.ac.uk/ena/data/view/AC092718
EMBL	AC131888	http://www.ebi.ac.uk/ena/data/view/AC131888
EMBL	AK098052	http://www.ebi.ac.uk/ena/data/view/AK098052
EMBL	AK127266	http://www.ebi.ac.uk/ena/data/view/AK127266
EMBL	AK131378	http://www.ebi.ac.uk/ena/data/view/AK131378
EMBL	AY164483	http://www.ebi.ac.uk/ena/data/view/AY164483
EMBL	AY371495	http://www.ebi.ac.uk/ena/data/view/AY371495
EMBL	BC004562	http://www.ebi.ac.uk/ena/data/view/BC004562
EMBL	BC014157	http://www.ebi.ac.uk/ena/data/view/BC014157
Ensembl	ENST00000337114	http://www.ensembl.org/id/ENST00000337114
Ensembl	ENST00000527937	http://www.ensembl.org/id/ENST00000527937
Ensembl	ENST00000531391	http://www.ensembl.org/id/ENST00000531391
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0030246	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030246
GO_process	GO:0050982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050982
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	2.60.60.20	http://www.cathdb.info/version/latest/superfamily/2.60.60.20
Gene3D	3.10.100.10	http://www.cathdb.info/version/latest/superfamily/3.10.100.10
GeneCards	PKD1L2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=PKD1L2
GeneID	114780	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=114780
GeneTree	ENSGT00860000134877	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00860000134877
H-InvDB	HIX0013271	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0013271
HGNC	HGNC:21715	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:21715
HOVERGEN	HBG108252	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108252&db=HOVERGEN
InParanoid	Q7Z442	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q7Z442
IntAct	Q7Z442	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q7Z442*
InterPro	IPR000203	http://www.ebi.ac.uk/interpro/entry/IPR000203
InterPro	IPR000922	http://www.ebi.ac.uk/interpro/entry/IPR000922
InterPro	IPR001024	http://www.ebi.ac.uk/interpro/entry/IPR001024
InterPro	IPR001304	http://www.ebi.ac.uk/interpro/entry/IPR001304
InterPro	IPR002859	http://www.ebi.ac.uk/interpro/entry/IPR002859
InterPro	IPR003915	http://www.ebi.ac.uk/interpro/entry/IPR003915
InterPro	IPR013122	http://www.ebi.ac.uk/interpro/entry/IPR013122
InterPro	IPR014010	http://www.ebi.ac.uk/interpro/entry/IPR014010
InterPro	IPR016186	http://www.ebi.ac.uk/interpro/entry/IPR016186
InterPro	IPR016187	http://www.ebi.ac.uk/interpro/entry/IPR016187
Jabion	114780	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=114780
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:114780	http://www.genome.jp/dbget-bin/www_bget?hsa:114780
KEGG_Orthology	KO:K04988	http://www.genome.jp/dbget-bin/www_bget?KO:K04988
MIM	607894	http://www.ncbi.nlm.nih.gov/omim/607894
PRINTS	PR01433	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01433
PROSITE	PS50041	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50041
PROSITE	PS50095	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50095
PROSITE	PS50221	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50221
PROSITE	PS50228	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50228
PROSITE	PS51111	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51111
PSORT	swissprot:PK1L2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:PK1L2_HUMAN
PSORT-B	swissprot:PK1L2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:PK1L2_HUMAN
PSORT2	swissprot:PK1L2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:PK1L2_HUMAN
Pfam	PF00059	http://pfam.xfam.org/family/PF00059
Pfam	PF01477	http://pfam.xfam.org/family/PF01477
Pfam	PF01825	http://pfam.xfam.org/family/PF01825
Pfam	PF02010	http://pfam.xfam.org/family/PF02010
Pfam	PF02140	http://pfam.xfam.org/family/PF02140
Pfam	PF08016	http://pfam.xfam.org/family/PF08016
PharmGKB	PA134874396	http://www.pharmgkb.org/do/serve?objId=PA134874396&objCls=Gene
Phobius	swissprot:PK1L2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:PK1L2_HUMAN
PhylomeDB	Q7Z442	http://phylomedb.org/?seqid=Q7Z442
ProteinModelPortal	Q7Z442	http://www.proteinmodelportal.org/query/uniprot/Q7Z442
PubMed	11572484	http://www.ncbi.nlm.nih.gov/pubmed/11572484
PubMed	12782129	http://www.ncbi.nlm.nih.gov/pubmed/12782129
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15203210	http://www.ncbi.nlm.nih.gov/pubmed/15203210
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15616553	http://www.ncbi.nlm.nih.gov/pubmed/15616553
RefSeq	NP_001070248	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001070248
RefSeq	NP_001265352	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001265352
RefSeq	NP_001265354	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001265354
RefSeq	NP_443124	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_443124
SMART	SM00034	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00034
SMART	SM00303	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00303
SMART	SM00308	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00308
SMR	Q7Z442	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q7Z442
STRING	9606.ENSP00000469432	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000469432&targetmode=cogs
SUPFAM	SSF49723	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49723
SUPFAM	SSF56436	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56436
UCSC	uc002fgi	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002fgi&org=rat
UniGene	Hs.413525	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.413525
UniProtKB	PK1L2_HUMAN	http://www.uniprot.org/uniprot/PK1L2_HUMAN
UniProtKB-AC	Q7Z442	http://www.uniprot.org/uniprot/Q7Z442
charge	swissprot:PK1L2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:PK1L2_HUMAN
eggNOG	ENOG410JFZI	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410JFZI
eggNOG	ENOG410Z7Z0	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z7Z0
epestfind	swissprot:PK1L2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:PK1L2_HUMAN
garnier	swissprot:PK1L2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:PK1L2_HUMAN
helixturnhelix	swissprot:PK1L2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:PK1L2_HUMAN
hmoment	swissprot:PK1L2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:PK1L2_HUMAN
iep	swissprot:PK1L2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:PK1L2_HUMAN
inforesidue	swissprot:PK1L2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:PK1L2_HUMAN
neXtProt	NX_Q7Z442	http://www.nextprot.org/db/entry/NX_Q7Z442
octanol	swissprot:PK1L2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:PK1L2_HUMAN
pepcoil	swissprot:PK1L2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:PK1L2_HUMAN
pepdigest	swissprot:PK1L2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:PK1L2_HUMAN
pepinfo	swissprot:PK1L2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:PK1L2_HUMAN
pepnet	swissprot:PK1L2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:PK1L2_HUMAN
pepstats	swissprot:PK1L2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:PK1L2_HUMAN
pepwheel	swissprot:PK1L2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:PK1L2_HUMAN
pepwindow	swissprot:PK1L2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:PK1L2_HUMAN
sigcleave	swissprot:PK1L2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:PK1L2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CY561_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P49447-1; Sequence=Displayed; Name=2; IsoId=P49447-2; Sequence=VSP_056950; Note=No experimental confirmation available.; 
# AltName	CY561_HUMAN	Cytochrome b-561
# BioGrid	107914	4
# CCDS	CCDS11636	-. [P49447-1]
# COFACTOR	CY561_HUMAN	Name=heme; Xref=ChEBI CHEBI 30413; Evidence={ECO 0000250}; Note=Binds 2 heme groups non-covalently. {ECO 0000250}; 
# ChiTaRS	CYB561	human
# Ensembl	ENST00000360793	ENSP00000354028; ENSG00000008283. [P49447-1]
# Ensembl	ENST00000392975	ENSP00000376701; ENSG00000008283. [P49447-1]
# Ensembl	ENST00000392976	ENSP00000376702; ENSG00000008283. [P49447-1]
# Ensembl	ENST00000448884	ENSP00000400350; ENSG00000008283. [P49447-2]
# Ensembl	ENST00000581573	ENSP00000462325; ENSG00000008283. [P49447-1]
# Ensembl	ENST00000584291	ENSP00000462543; ENSG00000008283. [P49447-1]
# ExpressionAtlas	P49447	baseline and differential
# FUNCTION	CY561_HUMAN	Secretory vesicle-specific electron transport protein. 
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_function	GO:0000293	ferric-chelate reductase activity; ISS:HGNC.
# GO_function	GO:0016491	oxidoreductase activity; IBA:GO_Central.
# GO_function	GO:0022865	transmembrane electron transfer carrier; NAS:UniProtKB.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0022900	electron transport chain; NAS:UniProtKB.
# GO_process	GO:0055114	oxidation-reduction process; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# GOslim_process	GO:0008150	biological_process
# Genevisible	P49447	HS
# HGNC	HGNC:2571	CYB561
# INTERACTION	CY561_HUMAN	Q92838 EDA; NbExp=3; IntAct=EBI-8646596, EBI-529425; Q99942 RNF5; NbExp=3; IntAct=EBI-8646596, EBI-348482; 
# IntAct	P49447	3
# InterPro	IPR006593	Cyt_b561/ferric_Rdtase_TM
# InterPro	IPR028837	Cytochrome_b561
# KEGG_Brite	ko02000	Transporters
# MIM	600019	gene
# Organism	CY561_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10106:SF14	PTHR10106:SF14
# PIR	S53321	S53321
# PROSITE	PS50939	CYTOCHROME_B561
# Pfam	PF03188	Cytochrom_B561
# Proteomes	UP000005640	Chromosome 17
# RecName	CY561_HUMAN	Cytochrome b561
# RefSeq	NP_001017916	NM_001017916.1. [P49447-1]
# RefSeq	NP_001017917	NM_001017917.1. [P49447-1]
# RefSeq	NP_001317350	NM_001330421.1
# RefSeq	NP_001906	NM_001915.3
# RefSeq	XP_005257148	XM_005257091.1. [P49447-1]
# SIMILARITY	Contains 1 cytochrome b561 domain. {ECO:0000255|PROSITE-ProRule	PRU00242}.
# SMART	SM00665	B561
# SUBCELLULAR LOCATION	CY561_HUMAN	Membrane; Multi-pass membrane protein. 
# TCDB	5.B.2.1	the eukaryotic cytochrome b561 (cytb561) family
# UCSC	uc002jap	human. [P49447-1]
# eggNOG	ENOG4111FKI	LUCA
# eggNOG	KOG1619	Eukaryota
BLAST	swissprot:CY561_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CY561_HUMAN
BioCyc	ZFISH:ENSG00000008283-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000008283-MONOMER
COXPRESdb	1534	http://coxpresdb.jp/data/gene/1534.shtml
CleanEx	HS_CYB561	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CYB561
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/bj3030915	http://dx.doi.org/10.1042/bj3030915
DOI	10.1074/jbc.270.39.22714	http://dx.doi.org/10.1074/jbc.270.39.22714
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC005828	http://www.ebi.ac.uk/ena/data/view/AC005828
EMBL	AK301541	http://www.ebi.ac.uk/ena/data/view/AK301541
EMBL	AK316606	http://www.ebi.ac.uk/ena/data/view/AK316606
EMBL	BC000021	http://www.ebi.ac.uk/ena/data/view/BC000021
EMBL	BC002976	http://www.ebi.ac.uk/ena/data/view/BC002976
EMBL	BC091485	http://www.ebi.ac.uk/ena/data/view/BC091485
EMBL	BT007096	http://www.ebi.ac.uk/ena/data/view/BT007096
EMBL	CH471109	http://www.ebi.ac.uk/ena/data/view/CH471109
EMBL	CH471109	http://www.ebi.ac.uk/ena/data/view/CH471109
EMBL	CH471109	http://www.ebi.ac.uk/ena/data/view/CH471109
EMBL	U06715	http://www.ebi.ac.uk/ena/data/view/U06715
EMBL	U29460	http://www.ebi.ac.uk/ena/data/view/U29460
EMBL	U29461	http://www.ebi.ac.uk/ena/data/view/U29461
EMBL	U29462	http://www.ebi.ac.uk/ena/data/view/U29462
EMBL	U29464	http://www.ebi.ac.uk/ena/data/view/U29464
EMBL	U29469	http://www.ebi.ac.uk/ena/data/view/U29469
Ensembl	ENST00000360793	http://www.ensembl.org/id/ENST00000360793
Ensembl	ENST00000392975	http://www.ensembl.org/id/ENST00000392975
Ensembl	ENST00000392976	http://www.ensembl.org/id/ENST00000392976
Ensembl	ENST00000448884	http://www.ensembl.org/id/ENST00000448884
Ensembl	ENST00000581573	http://www.ensembl.org/id/ENST00000581573
Ensembl	ENST00000584291	http://www.ensembl.org/id/ENST00000584291
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0000293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000293
GO_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GO_function	GO:0022865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022865
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0022900	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022900
GO_process	GO:0055114	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	CYB561	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CYB561
GeneID	1534	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1534
GeneTree	ENSGT00390000010986	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000010986
HGNC	HGNC:2571	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2571
HOVERGEN	HBG054164	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054164&db=HOVERGEN
HPA	HPA014753	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014753
InParanoid	P49447	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P49447
IntAct	P49447	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P49447*
InterPro	IPR006593	http://www.ebi.ac.uk/interpro/entry/IPR006593
InterPro	IPR028837	http://www.ebi.ac.uk/interpro/entry/IPR028837
Jabion	1534	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1534
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:1534	http://www.genome.jp/dbget-bin/www_bget?hsa:1534
KEGG_Orthology	KO:K08360	http://www.genome.jp/dbget-bin/www_bget?KO:K08360
MIM	600019	http://www.ncbi.nlm.nih.gov/omim/600019
PANTHER	PTHR10106:SF14	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10106:SF14
PROSITE	PS50939	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50939
PSORT	swissprot:CY561_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CY561_HUMAN
PSORT-B	swissprot:CY561_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CY561_HUMAN
PSORT2	swissprot:CY561_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CY561_HUMAN
Pfam	PF03188	http://pfam.xfam.org/family/PF03188
PharmGKB	PA27069	http://www.pharmgkb.org/do/serve?objId=PA27069&objCls=Gene
Phobius	swissprot:CY561_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CY561_HUMAN
PhylomeDB	P49447	http://phylomedb.org/?seqid=P49447
ProteinModelPortal	P49447	http://www.proteinmodelportal.org/query/uniprot/P49447
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	7559396	http://www.ncbi.nlm.nih.gov/pubmed/7559396
PubMed	7980462	http://www.ncbi.nlm.nih.gov/pubmed/7980462
RefSeq	NP_001017916	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001017916
RefSeq	NP_001017917	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001017917
RefSeq	NP_001317350	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001317350
RefSeq	NP_001906	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001906
RefSeq	XP_005257148	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005257148
SMART	SM00665	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00665
STRING	9606.ENSP00000354028	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000354028&targetmode=cogs
TCDB	5.B.2.1	http://www.tcdb.org/search/result.php?tc=5.B.2.1
UCSC	uc002jap	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002jap&org=rat
UniGene	Hs.355264	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.355264
UniProtKB	CY561_HUMAN	http://www.uniprot.org/uniprot/CY561_HUMAN
UniProtKB-AC	P49447	http://www.uniprot.org/uniprot/P49447
charge	swissprot:CY561_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CY561_HUMAN
eggNOG	ENOG4111FKI	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111FKI
eggNOG	KOG1619	http://eggnogapi.embl.de/nog_data/html/tree/KOG1619
epestfind	swissprot:CY561_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CY561_HUMAN
garnier	swissprot:CY561_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CY561_HUMAN
helixturnhelix	swissprot:CY561_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CY561_HUMAN
hmoment	swissprot:CY561_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CY561_HUMAN
iep	swissprot:CY561_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CY561_HUMAN
inforesidue	swissprot:CY561_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CY561_HUMAN
neXtProt	NX_P49447	http://www.nextprot.org/db/entry/NX_P49447
octanol	swissprot:CY561_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CY561_HUMAN
pepcoil	swissprot:CY561_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CY561_HUMAN
pepdigest	swissprot:CY561_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CY561_HUMAN
pepinfo	swissprot:CY561_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CY561_HUMAN
pepnet	swissprot:CY561_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CY561_HUMAN
pepstats	swissprot:CY561_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CY561_HUMAN
pepwheel	swissprot:CY561_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CY561_HUMAN
pepwindow	swissprot:CY561_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CY561_HUMAN
sigcleave	swissprot:CY561_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CY561_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ACHB4_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P30926-1; Sequence=Displayed; Name=2; IsoId=P30926-2; Sequence=VSP_046674, VSP_046675; 
# CCDS	CCDS10306	-. [P30926-1]
# CCDS	CCDS58392	-. [P30926-2]
# DrugBank	DB00184	Nicotine
# DrugBank	DB00514	Dextromethorphan
# DrugBank	DB00674	Galantamine
# DrugBank	DB00898	Ethanol
# DrugBank	DB01090	Pentolinium
# DrugBank	DB01227	Levomethadyl Acetate
# Ensembl	ENST00000261751	ENSP00000261751; ENSG00000117971. [P30926-1]
# Ensembl	ENST00000412074	ENSP00000416386; ENSG00000117971. [P30926-2]
# ExpressionAtlas	P30926	baseline and differential
# FUNCTION	ACHB4_HUMAN	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IC:UniProtKB.
# GO_component	GO:0005892	acetylcholine-gated channel complex; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0043005	neuron projection; IEA:Ensembl.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0004889	acetylcholine-activated cation-selective channel activity; TAS:UniProtKB.
# GO_function	GO:0008144	drug binding; IEA:Ensembl.
# GO_function	GO:0015276	ligand-gated ion channel activity; TAS:DFLAT.
# GO_function	GO:0015464	acetylcholine receptor activity; IDA:UniProtKB.
# GO_function	GO:0042166	acetylcholine binding; IEA:Ensembl.
# GO_process	GO:0001508	action potential; IEA:Ensembl.
# GO_process	GO:0006811	ion transport; TAS:UniProtKB.
# GO_process	GO:0006939	smooth muscle contraction; IEA:Ensembl.
# GO_process	GO:0006940	regulation of smooth muscle contraction; IEA:Ensembl.
# GO_process	GO:0007165	signal transduction; IDA:UniProtKB.
# GO_process	GO:0007271	synaptic transmission, cholinergic; TAS:ProtInc.
# GO_process	GO:0007626	locomotory behavior; IEA:Ensembl.
# GO_process	GO:0035094	response to nicotine; IBA:GO_Central.
# GO_process	GO:0035095	behavioral response to nicotine; IEA:Ensembl.
# GO_process	GO:0046928	regulation of neurotransmitter secretion; NAS:UniProtKB.
# GO_process	GO:0051291	protein heterooligomerization; IEA:Ensembl.
# GO_process	GO:0051971	positive regulation of transmission of nerve impulse; IEA:Ensembl.
# GO_process	GO:0060084	synaptic transmission involved in micturition; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.20.120.370	-; 2.
# Gene3D	2.70.170.10	-; 1.
# Genevisible	P30926	HS
# HGNC	HGNC:1964	CHRNB4
# InterPro	IPR002394	Nicotinic_acetylcholine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# InterPro	IPR027361	Acetylcholine_rcpt_TM
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04725	Cholinergic synapse
# MIM	118509	gene
# Organism	ACHB4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR18945	PTHR18945; 2
# PDB	2ASG	Model; -; B/D/E=262-284
# PIR	G02421	G02421
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00254	NICOTINICR
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 15
# Reactome	R-HSA-629587	Highly sodium permeable acetylcholine nicotinic receptors
# Reactome	R-HSA-629594	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
# Reactome	R-HSA-629597	Highly calcium permeable nicotinic acetylcholine receptors
# Reactome	R-HSA-6798695	Neutrophil degranulation
# RecName	ACHB4_HUMAN	Neuronal acetylcholine receptor subunit beta-4
# RefSeq	NP_000741	NM_000750.3. [P30926-1]
# RefSeq	NP_001243496	NM_001256567.1. [P30926-2]
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta- 4/CHRNB4 sub-subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	ACHB4_HUMAN	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Neuronal AChR is composed of two different types of subunits: alpha and beta. Beta-4 subunit can be combined to alpha- 2, alpha-3 or alpha-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly. {ECO	0000269|PubMed:16120769}. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TIGRFAMs	TIGR00860	LIC
# UCSC	uc002bed	human. [P30926-1]
# eggNOG	ENOG410XQGR	LUCA
# eggNOG	KOG3645	Eukaryota
BLAST	swissprot:ACHB4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ACHB4_HUMAN
BioCyc	ZFISH:ENSG00000117971-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000117971-MONOMER
COXPRESdb	1143	http://coxpresdb.jp/data/gene/1143.shtml
CleanEx	HS_CHRNB4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CHRNB4
DOI	10.1007/BF02736842	http://dx.doi.org/10.1007/BF02736842
DOI	10.1007/s100380170054	http://dx.doi.org/10.1007/s100380170054
DOI	10.1016/0014-5793(92)81411-E	http://dx.doi.org/10.1016/0014-5793(92)81411-E
DOI	10.1016/S0014-5793(96)01383-X	http://dx.doi.org/10.1016/S0014-5793(96)01383-X
DOI	10.1038/nature04601	http://dx.doi.org/10.1038/nature04601
DOI	10.1074/jbc.M110454200	http://dx.doi.org/10.1074/jbc.M110454200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1124/mol.105.017459	http://dx.doi.org/10.1124/mol.105.017459
DrugBank	DB00184	http://www.drugbank.ca/drugs/DB00184
DrugBank	DB00514	http://www.drugbank.ca/drugs/DB00514
DrugBank	DB00674	http://www.drugbank.ca/drugs/DB00674
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01090	http://www.drugbank.ca/drugs/DB01090
DrugBank	DB01227	http://www.drugbank.ca/drugs/DB01227
EMBL	AC022748	http://www.ebi.ac.uk/ena/data/view/AC022748
EMBL	AC067863	http://www.ebi.ac.uk/ena/data/view/AC067863
EMBL	AF306325	http://www.ebi.ac.uk/ena/data/view/AF306325
EMBL	AF306326	http://www.ebi.ac.uk/ena/data/view/AF306326
EMBL	AF306327	http://www.ebi.ac.uk/ena/data/view/AF306327
EMBL	AF306328	http://www.ebi.ac.uk/ena/data/view/AF306328
EMBL	AF306329	http://www.ebi.ac.uk/ena/data/view/AF306329
EMBL	AF453877	http://www.ebi.ac.uk/ena/data/view/AF453877
EMBL	AJ306454	http://www.ebi.ac.uk/ena/data/view/AJ306454
EMBL	AJ306455	http://www.ebi.ac.uk/ena/data/view/AJ306455
EMBL	AJ306456	http://www.ebi.ac.uk/ena/data/view/AJ306456
EMBL	AJ306457	http://www.ebi.ac.uk/ena/data/view/AJ306457
EMBL	AJ306458	http://www.ebi.ac.uk/ena/data/view/AJ306458
EMBL	AJ306459	http://www.ebi.ac.uk/ena/data/view/AJ306459
EMBL	BC096080	http://www.ebi.ac.uk/ena/data/view/BC096080
EMBL	BC096081	http://www.ebi.ac.uk/ena/data/view/BC096081
EMBL	BC096082	http://www.ebi.ac.uk/ena/data/view/BC096082
EMBL	BC096083	http://www.ebi.ac.uk/ena/data/view/BC096083
EMBL	U48861	http://www.ebi.ac.uk/ena/data/view/U48861
EMBL	U62439	http://www.ebi.ac.uk/ena/data/view/U62439
EMBL	X68275	http://www.ebi.ac.uk/ena/data/view/X68275
EMBL	Y08416	http://www.ebi.ac.uk/ena/data/view/Y08416
Ensembl	ENST00000261751	http://www.ensembl.org/id/ENST00000261751
Ensembl	ENST00000412074	http://www.ensembl.org/id/ENST00000412074
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005892	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005892
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0043005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043005
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0004889	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004889
GO_function	GO:0008144	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008144
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_function	GO:0015464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015464
GO_function	GO:0042166	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042166
GO_process	GO:0001508	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001508
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006939	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006939
GO_process	GO:0006940	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006940
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007271
GO_process	GO:0007626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007626
GO_process	GO:0035094	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035094
GO_process	GO:0035095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035095
GO_process	GO:0046928	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046928
GO_process	GO:0051291	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051291
GO_process	GO:0051971	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051971
GO_process	GO:0060084	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060084
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.20.120.370	http://www.cathdb.info/version/latest/superfamily/1.20.120.370
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	CHRNB4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CHRNB4
GeneID	1143	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1143
GeneTree	ENSGT00760000118930	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118930
HGNC	HGNC:1964	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1964
HOGENOM	HOG000006757	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006757&db=HOGENOM6
HOVERGEN	HBG003756	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003756&db=HOVERGEN
HPA	CAB000109	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB000109
InParanoid	P30926	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30926
IntAct	P30926	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30926*
InterPro	IPR002394	http://www.ebi.ac.uk/interpro/entry/IPR002394
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
InterPro	IPR027361	http://www.ebi.ac.uk/interpro/entry/IPR027361
Jabion	1143	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1143
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:1143	http://www.genome.jp/dbget-bin/www_bget?hsa:1143
KEGG_Orthology	KO:K04815	http://www.genome.jp/dbget-bin/www_bget?KO:K04815
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04725	http://www.genome.jp/kegg-bin/show_pathway?ko04725
MIM	118509	http://www.ncbi.nlm.nih.gov/omim/118509
OMA	FMKRPGP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FMKRPGP
OrthoDB	EOG091G0R20	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0R20
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PDB	2ASG	http://www.ebi.ac.uk/pdbe-srv/view/entry/2ASG
PDBsum	2ASG	http://www.ebi.ac.uk/pdbsum/2ASG
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00254	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00254
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:ACHB4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ACHB4_HUMAN
PSORT-B	swissprot:ACHB4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ACHB4_HUMAN
PSORT2	swissprot:ACHB4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ACHB4_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA26496	http://www.pharmgkb.org/do/serve?objId=PA26496&objCls=Gene
Phobius	swissprot:ACHB4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ACHB4_HUMAN
PhylomeDB	P30926	http://phylomedb.org/?seqid=P30926
ProteinModelPortal	P30926	http://www.proteinmodelportal.org/query/uniprot/P30926
PubMed	11450844	http://www.ncbi.nlm.nih.gov/pubmed/11450844
PubMed	11742001	http://www.ncbi.nlm.nih.gov/pubmed/11742001
PubMed	1330682	http://www.ncbi.nlm.nih.gov/pubmed/1330682
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16120769	http://www.ncbi.nlm.nih.gov/pubmed/16120769
PubMed	16572171	http://www.ncbi.nlm.nih.gov/pubmed/16572171
PubMed	8906617	http://www.ncbi.nlm.nih.gov/pubmed/8906617
PubMed	9009220	http://www.ncbi.nlm.nih.gov/pubmed/9009220
PubMed	9203638	http://www.ncbi.nlm.nih.gov/pubmed/9203638
Reactome	R-HSA-629587	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-629587
Reactome	R-HSA-629594	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-629594
Reactome	R-HSA-629597	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-629597
Reactome	R-HSA-6798695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6798695
RefSeq	NP_000741	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000741
RefSeq	NP_001243496	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243496
STRING	9606.ENSP00000261751	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000261751&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc002bed	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002bed&org=rat
UniGene	Hs.624178	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.624178
UniProtKB	ACHB4_HUMAN	http://www.uniprot.org/uniprot/ACHB4_HUMAN
UniProtKB-AC	P30926	http://www.uniprot.org/uniprot/P30926
charge	swissprot:ACHB4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ACHB4_HUMAN
eggNOG	ENOG410XQGR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQGR
eggNOG	KOG3645	http://eggnogapi.embl.de/nog_data/html/tree/KOG3645
epestfind	swissprot:ACHB4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ACHB4_HUMAN
garnier	swissprot:ACHB4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ACHB4_HUMAN
helixturnhelix	swissprot:ACHB4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACHB4_HUMAN
hmoment	swissprot:ACHB4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ACHB4_HUMAN
iep	swissprot:ACHB4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ACHB4_HUMAN
inforesidue	swissprot:ACHB4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ACHB4_HUMAN
neXtProt	NX_P30926	http://www.nextprot.org/db/entry/NX_P30926
octanol	swissprot:ACHB4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ACHB4_HUMAN
pepcoil	swissprot:ACHB4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ACHB4_HUMAN
pepdigest	swissprot:ACHB4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ACHB4_HUMAN
pepinfo	swissprot:ACHB4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ACHB4_HUMAN
pepnet	swissprot:ACHB4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ACHB4_HUMAN
pepstats	swissprot:ACHB4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ACHB4_HUMAN
pepwheel	swissprot:ACHB4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ACHB4_HUMAN
pepwindow	swissprot:ACHB4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ACHB4_HUMAN
sigcleave	swissprot:ACHB4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ACHB4_HUMAN
## Database	ID	URL or Descriptions
# AltName	TPC2_HUMAN	Voltage-dependent calcium channel protein TPC2
# BioGrid	128596	51
# ChiTaRS	TPCN2	human
# DOMAIN	TPC2_HUMAN	Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position (By similarity). {ECO 0000250}. 
# Ensembl	ENST00000294309	ENSP00000294309; ENSG00000162341
# ExpressionAtlas	Q8NHX9	baseline and differential
# FUNCTION	TPC2_HUMAN	Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction. {ECO 0000269|PubMed 19387438, ECO 0000269|PubMed 19620632}. 
# GO_component	GO:0005764	lysosome; IDA:ParkinsonsUK-UCL.
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0010008	endosome membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005245	voltage-gated calcium channel activity; ISS:UniProtKB.
# GO_function	GO:0019901	protein kinase binding; IPI:UniProtKB.
# GO_function	GO:0072345	NAADP-sensitive calcium-release channel activity; IDA:UniProtKB.
# GO_process	GO:0006874	cellular calcium ion homeostasis; IDA:UniProtKB.
# GO_process	GO:0006939	smooth muscle contraction; ISS:UniProtKB.
# GO_process	GO:0007040	lysosome organization; IGI:ParkinsonsUK-UCL.
# GO_process	GO:0010506	regulation of autophagy; IGI:ParkinsonsUK-UCL.
# GO_process	GO:0019722	calcium-mediated signaling; IGI:ParkinsonsUK-UCL.
# GO_process	GO:0033280	response to vitamin D; IEA:Ensembl.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0086010	membrane depolarization during action potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005764	lysosome
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.350	-; 1.
# Genevisible	Q8NHX9	HS
# HGNC	HGNC:20820	TPCN2
# INTERACTION	TPC2_HUMAN	Self; NbExp=4; IntAct=EBI-5239949, EBI-5239949; O00165 HAX1; NbExp=4; IntAct=EBI-5239949, EBI-357001; P42345 MTOR; NbExp=2; IntAct=EBI-5239949, EBI-359260; Q9ULQ1 TPCN1; NbExp=9; IntAct=EBI-5239949, EBI-5239895; 
# IntAct	Q8NHX9	3
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR027359	Channel_four-helix_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko04972	Pancreatic secretion
# MIM	612163	gene
# MIM	612267	phenotype
# Organism	TPC2_HUMAN	Homo sapiens (Human)
# PIR	T46421	T46421
# POLYMORPHISM	Genetic variants in TPCN2 define the skin/hair/eye pigmentation variation locus 10 (SHEP10) [MIM:612267]. Hair, eye and skin pigmentation are among the most visible examples of human phenotypic variation, with a broad normal range that is subject to substantial geographic stratification. In the case of skin, individuals tend to have lighter pigmentation with increasing distance from the equator. By contrast, the majority of variation in human eye and hair color is found among individuals of European ancestry, with most other human populations fixed for brown eyes and black hair. {ECO	0000269|PubMed:18488028}. 
# PTM	TPC2_HUMAN	N-glycosylated. {ECO 0000250}. 
# Pfam	PF00520	Ion_trans; 2
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	TPC2_HUMAN	Two pore calcium channel protein 2
# RefSeq	NP_620714	NM_139075.3
# SIMILARITY	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	TPC2_HUMAN	Lysosome membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Note=Only the acidic lysosomal fraction is sensitive to NAADP. {ECO 0000250}. 
# SUBUNIT	TPC2_HUMAN	Homodimer (By similarity). Interacts with LRRK2 (PubMed 22012985). Interacts with HAX1 (PubMed 24188827). {ECO 0000250|UniProtKB Q8BWC0, ECO 0000269|PubMed 22012985, ECO 0000269|PubMed 24188827}. 
# TCDB	1.A.1.11.19	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	Widely expressed. Expressed at high level in liver and kidney. {ECO:0000269|PubMed	19387438}. 
# UCSC	uc001oos	human
# eggNOG	ENOG410INF1	Eukaryota
# eggNOG	ENOG4111V21	LUCA
BLAST	swissprot:TPC2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TPC2_HUMAN
COXPRESdb	219931	http://coxpresdb.jp/data/gene/219931.shtml
CleanEx	HS_TPCN2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TPCN2
DOI	10.1016/j.febslet.2013.10.031	http://dx.doi.org/10.1016/j.febslet.2013.10.031
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1038/nature08030	http://dx.doi.org/10.1038/nature08030
DOI	10.1038/ng.160	http://dx.doi.org/10.1038/ng.160
DOI	10.1083/jcb.200904073	http://dx.doi.org/10.1083/jcb.200904073
DOI	10.1093/hmg/ddr481	http://dx.doi.org/10.1093/hmg/ddr481
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AL137479	http://www.ebi.ac.uk/ena/data/view/AL137479
EMBL	AP003071	http://www.ebi.ac.uk/ena/data/view/AP003071
EMBL	AY029200	http://www.ebi.ac.uk/ena/data/view/AY029200
EMBL	BC063008	http://www.ebi.ac.uk/ena/data/view/BC063008
Ensembl	ENST00000294309	http://www.ensembl.org/id/ENST00000294309
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0010008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010008
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0019901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019901
GO_function	GO:0072345	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072345
GO_process	GO:0006874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874
GO_process	GO:0006939	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006939
GO_process	GO:0007040	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007040
GO_process	GO:0010506	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010506
GO_process	GO:0019722	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019722
GO_process	GO:0033280	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033280
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0086010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086010
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	TPCN2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TPCN2
GeneID	219931	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=219931
GeneTree	ENSGT00530000063660	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063660
H-InvDB	HIX0019754	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0019754
HGNC	HGNC:20820	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20820
HOGENOM	HOG000154668	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000154668&db=HOGENOM6
HOVERGEN	HBG079776	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG079776&db=HOVERGEN
HPA	HPA016561	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA016561
HPA	HPA027080	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA027080
InParanoid	Q8NHX9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8NHX9
IntAct	Q8NHX9	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8NHX9*
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
Jabion	219931	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=219931
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:219931	http://www.genome.jp/dbget-bin/www_bget?hsa:219931
KEGG_Orthology	KO:K14077	http://www.genome.jp/dbget-bin/www_bget?KO:K14077
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
MIM	612163	http://www.ncbi.nlm.nih.gov/omim/612163
MIM	612267	http://www.ncbi.nlm.nih.gov/omim/612267
OMA	FVFGHYY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FVFGHYY
OrthoDB	EOG091G045K	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G045K
PSORT	swissprot:TPC2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TPC2_HUMAN
PSORT-B	swissprot:TPC2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TPC2_HUMAN
PSORT2	swissprot:TPC2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TPC2_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
PharmGKB	PA134937857	http://www.pharmgkb.org/do/serve?objId=PA134937857&objCls=Gene
Phobius	swissprot:TPC2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TPC2_HUMAN
PhylomeDB	Q8NHX9	http://phylomedb.org/?seqid=Q8NHX9
ProteinModelPortal	Q8NHX9	http://www.proteinmodelportal.org/query/uniprot/Q8NHX9
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18488028	http://www.ncbi.nlm.nih.gov/pubmed/18488028
PubMed	19387438	http://www.ncbi.nlm.nih.gov/pubmed/19387438
PubMed	19620632	http://www.ncbi.nlm.nih.gov/pubmed/19620632
PubMed	22012985	http://www.ncbi.nlm.nih.gov/pubmed/22012985
PubMed	24188827	http://www.ncbi.nlm.nih.gov/pubmed/24188827
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_620714	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_620714
STRING	9606.ENSP00000294309	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000294309&targetmode=cogs
TCDB	1.A.1.11.19	http://www.tcdb.org/search/result.php?tc=1.A.1.11.19
UCSC	uc001oos	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001oos&org=rat
UniGene	Hs.131851	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.131851
UniProtKB	TPC2_HUMAN	http://www.uniprot.org/uniprot/TPC2_HUMAN
UniProtKB-AC	Q8NHX9	http://www.uniprot.org/uniprot/Q8NHX9
charge	swissprot:TPC2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TPC2_HUMAN
eggNOG	ENOG410INF1	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410INF1
eggNOG	ENOG4111V21	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111V21
epestfind	swissprot:TPC2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TPC2_HUMAN
garnier	swissprot:TPC2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TPC2_HUMAN
helixturnhelix	swissprot:TPC2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TPC2_HUMAN
hmoment	swissprot:TPC2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TPC2_HUMAN
iep	swissprot:TPC2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TPC2_HUMAN
inforesidue	swissprot:TPC2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TPC2_HUMAN
neXtProt	NX_Q8NHX9	http://www.nextprot.org/db/entry/NX_Q8NHX9
octanol	swissprot:TPC2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TPC2_HUMAN
pepcoil	swissprot:TPC2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TPC2_HUMAN
pepdigest	swissprot:TPC2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TPC2_HUMAN
pepinfo	swissprot:TPC2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TPC2_HUMAN
pepnet	swissprot:TPC2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TPC2_HUMAN
pepstats	swissprot:TPC2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TPC2_HUMAN
pepwheel	swissprot:TPC2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TPC2_HUMAN
pepwindow	swissprot:TPC2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TPC2_HUMAN
sigcleave	swissprot:TPC2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TPC2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GRID1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ULK0-1; Sequence=Displayed; Name=2; IsoId=Q9ULK0-2; Sequence=VSP_057019; Note=No experimental confirmation available.; 
# BioGrid	109151	4
# CCDS	CCDS31236	-. [Q9ULK0-1]
# ChiTaRS	GRID1	human
# Ensembl	ENST00000327946	ENSP00000330148; ENSG00000182771. [Q9ULK0-1]
# ExpressionAtlas	Q9ULK0	baseline and differential
# FUNCTION	GRID1_HUMAN	Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. 
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0004970	ionotropic glutamate receptor activity; IEA:InterPro.
# GO_function	GO:0005234	extracellular-glutamate-gated ion channel activity; IEA:InterPro.
# GO_process	GO:0035176	social behavior; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q9ULK0	HS
# HGNC	HGNC:4575	GRID1
# InterPro	IPR001320	Iontro_rcpt
# InterPro	IPR001508	Iono_rcpt_met
# InterPro	IPR001828	ANF_lig-bd_rcpt
# InterPro	IPR019594	Glu/Gly-bd
# InterPro	IPR028082	Peripla_BP_I
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# MIM	610659	gene
# Organism	GRID1_HUMAN	Homo sapiens (Human)
# PRINTS	PR00177	NMDARECEPTOR
# Pfam	PF00060	Lig_chan
# Pfam	PF01094	ANF_receptor
# Pfam	PF10613	Lig_chan-Glu_bd
# Proteomes	UP000005640	Chromosome 10
# RecName	GRID1_HUMAN	Glutamate receptor ionotropic, delta-1
# RefSeq	NP_060021	NM_017551.2. [Q9ULK0-1]
# SIMILARITY	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID1 subfamily. {ECO	0000305}.
# SMART	SM00079	PBPe
# SMART	SM00918	Lig_chan-Glu_bd
# SUBCELLULAR LOCATION	GRID1_HUMAN	Cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUBUNIT	Interacts with CBLN1, and more weakly with CBLN2. {ECO	0000250}. 
# SUPFAM	SSF53822	SSF53822
# UCSC	uc001kdl	human. [Q9ULK0-1]
# eggNOG	ENOG410XQQV	LUCA
# eggNOG	KOG1052	Eukaryota
BLAST	swissprot:GRID1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GRID1_HUMAN
BioCyc	ZFISH:G66-31135-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31135-MONOMER
COXPRESdb	2894	http://coxpresdb.jp/data/gene/2894.shtml
CleanEx	HS_GRID1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GRID1
DOI	10.1038/nature02462	http://dx.doi.org/10.1038/nature02462
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/dnares/6.5.337	http://dx.doi.org/10.1093/dnares/6.5.337
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB033046	http://www.ebi.ac.uk/ena/data/view/AB033046
EMBL	AC022028	http://www.ebi.ac.uk/ena/data/view/AC022028
EMBL	AC073162	http://www.ebi.ac.uk/ena/data/view/AC073162
EMBL	AC079955	http://www.ebi.ac.uk/ena/data/view/AC079955
EMBL	AK127168	http://www.ebi.ac.uk/ena/data/view/AK127168
EMBL	AK302192	http://www.ebi.ac.uk/ena/data/view/AK302192
EMBL	AL451059	http://www.ebi.ac.uk/ena/data/view/AL451059
EMBL	AL596135	http://www.ebi.ac.uk/ena/data/view/AL596135
EMBL	AL683834	http://www.ebi.ac.uk/ena/data/view/AL683834
EMBL	AL732479	http://www.ebi.ac.uk/ena/data/view/AL732479
EMBL	AL844892	http://www.ebi.ac.uk/ena/data/view/AL844892
EMBL	BC039263	http://www.ebi.ac.uk/ena/data/view/BC039263
EMBL	CH471142	http://www.ebi.ac.uk/ena/data/view/CH471142
Ensembl	ENST00000327946	http://www.ensembl.org/id/ENST00000327946
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0004970	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004970
GO_function	GO:0005234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005234
GO_process	GO:0035176	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035176
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	GRID1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GRID1
GeneID	2894	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2894
GeneTree	ENSGT00760000118920	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118920
HGNC	HGNC:4575	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4575
HOGENOM	HOG000264260	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264260&db=HOGENOM6
HOVERGEN	HBG051840	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051840&db=HOVERGEN
InParanoid	Q9ULK0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9ULK0
InterPro	IPR001320	http://www.ebi.ac.uk/interpro/entry/IPR001320
InterPro	IPR001508	http://www.ebi.ac.uk/interpro/entry/IPR001508
InterPro	IPR001828	http://www.ebi.ac.uk/interpro/entry/IPR001828
InterPro	IPR019594	http://www.ebi.ac.uk/interpro/entry/IPR019594
InterPro	IPR028082	http://www.ebi.ac.uk/interpro/entry/IPR028082
Jabion	2894	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2894
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:2894	http://www.genome.jp/dbget-bin/www_bget?hsa:2894
KEGG_Orthology	KO:K05206	http://www.genome.jp/dbget-bin/www_bget?KO:K05206
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
MIM	610659	http://www.ncbi.nlm.nih.gov/omim/610659
OMA	MGRCDLT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MGRCDLT
OrthoDB	EOG091G010L	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G010L
PRINTS	PR00177	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00177
PSORT	swissprot:GRID1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GRID1_HUMAN
PSORT-B	swissprot:GRID1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GRID1_HUMAN
PSORT2	swissprot:GRID1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GRID1_HUMAN
Pfam	PF00060	http://pfam.xfam.org/family/PF00060
Pfam	PF01094	http://pfam.xfam.org/family/PF01094
Pfam	PF10613	http://pfam.xfam.org/family/PF10613
PharmGKB	PA28970	http://www.pharmgkb.org/do/serve?objId=PA28970&objCls=Gene
Phobius	swissprot:GRID1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GRID1_HUMAN
PhylomeDB	Q9ULK0	http://phylomedb.org/?seqid=Q9ULK0
ProteinModelPortal	Q9ULK0	http://www.proteinmodelportal.org/query/uniprot/Q9ULK0
PubMed	10574462	http://www.ncbi.nlm.nih.gov/pubmed/10574462
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15164054	http://www.ncbi.nlm.nih.gov/pubmed/15164054
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
RefSeq	NP_060021	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060021
SMART	SM00079	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00079
SMART	SM00918	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00918
SMR	Q9ULK0	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9ULK0
STRING	9606.ENSP00000330148	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000330148&targetmode=cogs
SUPFAM	SSF53822	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822
UCSC	uc001kdl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001kdl&org=rat
UniGene	Hs.530653	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.530653
UniProtKB	GRID1_HUMAN	http://www.uniprot.org/uniprot/GRID1_HUMAN
UniProtKB-AC	Q9ULK0	http://www.uniprot.org/uniprot/Q9ULK0
charge	swissprot:GRID1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GRID1_HUMAN
eggNOG	ENOG410XQQV	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQQV
eggNOG	KOG1052	http://eggnogapi.embl.de/nog_data/html/tree/KOG1052
epestfind	swissprot:GRID1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GRID1_HUMAN
garnier	swissprot:GRID1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GRID1_HUMAN
helixturnhelix	swissprot:GRID1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GRID1_HUMAN
hmoment	swissprot:GRID1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GRID1_HUMAN
iep	swissprot:GRID1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GRID1_HUMAN
inforesidue	swissprot:GRID1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GRID1_HUMAN
neXtProt	NX_Q9ULK0	http://www.nextprot.org/db/entry/NX_Q9ULK0
octanol	swissprot:GRID1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GRID1_HUMAN
pepcoil	swissprot:GRID1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GRID1_HUMAN
pepdigest	swissprot:GRID1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GRID1_HUMAN
pepinfo	swissprot:GRID1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GRID1_HUMAN
pepnet	swissprot:GRID1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GRID1_HUMAN
pepstats	swissprot:GRID1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GRID1_HUMAN
pepwheel	swissprot:GRID1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GRID1_HUMAN
pepwindow	swissprot:GRID1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GRID1_HUMAN
sigcleave	swissprot:GRID1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GRID1_HUMAN
## Database	ID	URL or Descriptions
# AltName	S2542_HUMAN	Solute carrier family 25 member 42
# BioGrid	129877	2
# Ensembl	ENST00000318596	ENSP00000326693; ENSG00000181035
# ExpressionAtlas	Q86VD7	baseline and differential
# FUNCTION	S2542_HUMAN	Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'- diphosphate. {ECO 0000269|PubMed 19429682}. 
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005347	ATP transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015217	ADP transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015228	coenzyme A transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0043262	adenosine-diphosphatase activity; IDA:UniProtKB.
# GO_function	GO:0080122	AMP transmembrane transporter activity; IDA:UniProtKB.
# GO_process	GO:0015866	ADP transport; IDA:UniProtKB.
# GO_process	GO:0015867	ATP transport; IDA:UniProtKB.
# GO_process	GO:0035349	coenzyme A transmembrane transport; IDA:UniProtKB.
# GO_process	GO:0080121	AMP transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005739	mitochondrion
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.50.40.10	-; 1.
# Genevisible	Q86VD7	HS
# HGNC	HGNC:28380	SLC25A42
# IntAct	Q86VD7	4
# InterPro	IPR002067	Mit_carrier
# InterPro	IPR002167	Graves_DC
# InterPro	IPR014762	DNA_mismatch_repair_CS
# InterPro	IPR018108	Mitochondrial_sb/sol_carrier
# InterPro	IPR023395	Mt_carrier_dom
# KEGG_Brite	ko02001	Solute carrier family
# MIM	610823	gene
# Organism	S2542_HUMAN	Homo sapiens (Human)
# PRINTS	PR00926	MITOCARRIER
# PRINTS	PR00928	GRAVESDC
# PROSITE	PS50920	SOLCAR; 3
# Pfam	PF00153	Mito_carr; 3
# Proteomes	UP000005640	Chromosome 19
# RecName	S2542_HUMAN	Mitochondrial coenzyme A transporter SLC25A42
# RefSeq	NP_001308473	NM_001321544.1
# RefSeq	NP_848621	NM_178526.4
# RefSeq	XP_005259918	XM_005259861.3
# RefSeq	XP_011526239	XM_011527937.2
# SEQUENCE CAUTION	Sequence=AAC02758.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the mitochondrial carrier (TC 2.A.29) family. {ECO	0000305}. 
# SIMILARITY	Contains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule	PRU00282}. 
# SUBCELLULAR LOCATION	S2542_HUMAN	Mitochondrion inner membrane {ECO 0000269|PubMed 19429682}; Multi-pass membrane protein {ECO 0000269|PubMed 19429682}. 
# SUPFAM	SSF103506	SSF103506
# TCDB	2.A.29.12	the mitochondrial carrier (mc) family
# UCSC	uc002nlf	human
# eggNOG	ENOG410ZRF1	LUCA
# eggNOG	KOG0752	Eukaryota
BLAST	swissprot:S2542_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S2542_HUMAN
COXPRESdb	284439	http://coxpresdb.jp/data/gene/284439.shtml
CleanEx	HS_SLC25A42	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC25A42
DOI	10.1016/j.ygeno.2006.06.016	http://dx.doi.org/10.1016/j.ygeno.2006.06.016
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DOI	10.1074/jbc.M109.014118	http://dx.doi.org/10.1074/jbc.M109.014118
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC002126	http://www.ebi.ac.uk/ena/data/view/AC002126
EMBL	AC004143	http://www.ebi.ac.uk/ena/data/view/AC004143
EMBL	BC045598	http://www.ebi.ac.uk/ena/data/view/BC045598
EMBL	FN356975	http://www.ebi.ac.uk/ena/data/view/FN356975
Ensembl	ENST00000318596	http://www.ensembl.org/id/ENST00000318596
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005347	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005347
GO_function	GO:0015217	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015217
GO_function	GO:0015228	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015228
GO_function	GO:0043262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043262
GO_function	GO:0080122	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0080122
GO_process	GO:0015866	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015866
GO_process	GO:0015867	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015867
GO_process	GO:0035349	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035349
GO_process	GO:0080121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0080121
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.50.40.10	http://www.cathdb.info/version/latest/superfamily/1.50.40.10
GeneCards	SLC25A42	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC25A42
GeneID	284439	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=284439
GeneTree	ENSGT00760000119245	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119245
H-InvDB	HIX0027465	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0027465
HGNC	HGNC:28380	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:28380
HOGENOM	HOG000165726	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000165726&db=HOGENOM6
HOVERGEN	HBG104402	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG104402&db=HOVERGEN
HPA	HPA049449	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA049449
InParanoid	Q86VD7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q86VD7
IntAct	Q86VD7	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q86VD7*
InterPro	IPR002067	http://www.ebi.ac.uk/interpro/entry/IPR002067
InterPro	IPR002167	http://www.ebi.ac.uk/interpro/entry/IPR002167
InterPro	IPR014762	http://www.ebi.ac.uk/interpro/entry/IPR014762
InterPro	IPR018108	http://www.ebi.ac.uk/interpro/entry/IPR018108
InterPro	IPR023395	http://www.ebi.ac.uk/interpro/entry/IPR023395
Jabion	284439	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=284439
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:284439	http://www.genome.jp/dbget-bin/www_bget?hsa:284439
KEGG_Orthology	KO:K15085	http://www.genome.jp/dbget-bin/www_bget?KO:K15085
MIM	610823	http://www.ncbi.nlm.nih.gov/omim/610823
OMA	EYSGRPQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EYSGRPQ
OrthoDB	EOG091G0C8S	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0C8S
PRINTS	PR00926	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00926
PRINTS	PR00928	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00928
PROSITE	PS50920	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50920
PSORT	swissprot:S2542_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S2542_HUMAN
PSORT-B	swissprot:S2542_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S2542_HUMAN
PSORT2	swissprot:S2542_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S2542_HUMAN
Pfam	PF00153	http://pfam.xfam.org/family/PF00153
PharmGKB	PA162403703	http://www.pharmgkb.org/do/serve?objId=PA162403703&objCls=Gene
Phobius	swissprot:S2542_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S2542_HUMAN
PhylomeDB	Q86VD7	http://phylomedb.org/?seqid=Q86VD7
ProteinModelPortal	Q86VD7	http://www.proteinmodelportal.org/query/uniprot/Q86VD7
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16949250	http://www.ncbi.nlm.nih.gov/pubmed/16949250
PubMed	19429682	http://www.ncbi.nlm.nih.gov/pubmed/19429682
RefSeq	NP_001308473	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001308473
RefSeq	NP_848621	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_848621
RefSeq	XP_005259918	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005259918
RefSeq	XP_011526239	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011526239
SMR	Q86VD7	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q86VD7
STRING	9606.ENSP00000326693	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000326693&targetmode=cogs
SUPFAM	SSF103506	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103506
TCDB	2.A.29.12	http://www.tcdb.org/search/result.php?tc=2.A.29.12
UCSC	uc002nlf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002nlf&org=rat
UniGene	Hs.303669	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.303669
UniProtKB	S2542_HUMAN	http://www.uniprot.org/uniprot/S2542_HUMAN
UniProtKB-AC	Q86VD7	http://www.uniprot.org/uniprot/Q86VD7
charge	swissprot:S2542_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S2542_HUMAN
eggNOG	ENOG410ZRF1	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZRF1
eggNOG	KOG0752	http://eggnogapi.embl.de/nog_data/html/tree/KOG0752
epestfind	swissprot:S2542_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S2542_HUMAN
garnier	swissprot:S2542_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S2542_HUMAN
helixturnhelix	swissprot:S2542_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S2542_HUMAN
hmoment	swissprot:S2542_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S2542_HUMAN
iep	swissprot:S2542_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S2542_HUMAN
inforesidue	swissprot:S2542_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S2542_HUMAN
neXtProt	NX_Q86VD7	http://www.nextprot.org/db/entry/NX_Q86VD7
octanol	swissprot:S2542_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S2542_HUMAN
pepcoil	swissprot:S2542_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S2542_HUMAN
pepdigest	swissprot:S2542_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S2542_HUMAN
pepinfo	swissprot:S2542_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S2542_HUMAN
pepnet	swissprot:S2542_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S2542_HUMAN
pepstats	swissprot:S2542_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S2542_HUMAN
pepwheel	swissprot:S2542_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S2542_HUMAN
pepwindow	swissprot:S2542_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S2542_HUMAN
sigcleave	swissprot:S2542_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S2542_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNE1_HUMAN	Delayed rectifier potassium channel subunit IsK
# AltName	KCNE1_HUMAN	IKs producing slow voltage-gated potassium channel subunit beta Mink
# AltName	KCNE1_HUMAN	Minimal potassium channel
# BioGrid	109955	5
# ChiTaRS	KCNE1	human
# DISEASE	KCNE1_HUMAN	Jervell and Lange-Nielsen syndrome 2 (JLNS2) [MIM 612347]  An autosomal recessive disorder characterized by congenital deafness, prolongation of the QT interval, syncopal attacks due to ventricular arrhythmias, and a high risk of sudden death. {ECO 0000269|PubMed 10400998, ECO 0000269|PubMed 9328483, ECO 0000269|PubMed 9354783}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	KCNE1_HUMAN	Long QT syndrome 5 (LQT5) [MIM 613695]  A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. {ECO 0000269|PubMed 10400998, ECO 0000269|PubMed 10973849, ECO 0000269|PubMed 11692163, ECO 0000269|PubMed 16414944, ECO 0000269|PubMed 19716085, ECO 0000269|PubMed 9354802, ECO 0000269|PubMed 9445165}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00808	Indapamide
# Ensembl	ENST00000337385	ENSP00000337255; ENSG00000180509
# Ensembl	ENST00000399284	ENSP00000382225; ENSG00000180509
# Ensembl	ENST00000399286	ENSP00000382226; ENSG00000180509
# Ensembl	ENST00000399289	ENSP00000382228; ENSG00000180509
# Ensembl	ENST00000416357	ENSP00000416258; ENSG00000180509
# Ensembl	ENST00000432085	ENSP00000412498; ENSG00000180509
# Ensembl	ENST00000611936	ENSP00000478215; ENSG00000180509
# Ensembl	ENST00000621601	ENSP00000483895; ENSG00000180509
# ExpressionAtlas	P15382	baseline and differential
# FUNCTION	KCNE1_HUMAN	Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed 19219384). Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr). {ECO 0000269|PubMed 19219384}. 
# GO_component	GO:0005764	lysosome; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IDA:BHF-UCL.
# GO_component	GO:0009986	cell surface; IDA:BHF-UCL.
# GO_component	GO:0016324	apical plasma membrane; ISS:BHF-UCL.
# GO_component	GO:0030018	Z disc; ISS:BHF-UCL.
# GO_component	GO:0045121	membrane raft; IEA:UniProtKB-SubCell.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; IDA:UniProtKB.
# GO_function	GO:0015459	potassium channel regulator activity; IDA:UniProtKB.
# GO_function	GO:0031433	telethonin binding; IPI:BHF-UCL.
# GO_process	GO:0006487	protein N-linked glycosylation; IDA:UniProtKB.
# GO_process	GO:0006493	protein O-linked glycosylation; IDA:UniProtKB.
# GO_process	GO:0007605	sensory perception of sound; TAS:ProtInc.
# GO_process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization; IMP:BHF-UCL.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:0071320	cellular response to cAMP; IDA:BHF-UCL.
# GO_process	GO:0071435	potassium ion export; IDA:BHF-UCL.
# GO_process	GO:0071805	potassium ion transmembrane transport; IDA:BHF-UCL.
# GO_process	GO:0086002	cardiac muscle cell action potential involved in contraction; IMP:BHF-UCL.
# GO_process	GO:0086005	ventricular cardiac muscle cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086009	membrane repolarization; IDA:BHF-UCL.
# GO_process	GO:0086011	membrane repolarization during action potential; IDA:BHF-UCL.
# GO_process	GO:0086013	membrane repolarization during cardiac muscle cell action potential; IDA:BHF-UCL.
# GO_process	GO:0086091	regulation of heart rate by cardiac conduction; IMP:BHF-UCL.
# GO_process	GO:0090315	negative regulation of protein targeting to membrane; ISS:BHF-UCL.
# GO_process	GO:0098915	membrane repolarization during ventricular cardiac muscle cell action potential; IMP:BHF-UCL.
# GO_process	GO:1901379	regulation of potassium ion transmembrane transport; IDA:BHF-UCL.
# GO_process	GO:1901381	positive regulation of potassium ion transmembrane transport; IDA:BHF-UCL.
# GO_process	GO:1902259	regulation of delayed rectifier potassium channel activity; IDA:BHF-UCL.
# GO_process	GO:1902260	negative regulation of delayed rectifier potassium channel activity; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005764	lysosome
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008092	cytoskeletal protein binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P15382	HS
# HGNC	HGNC:6240	KCNE1
# INTERACTION	KCNE1_HUMAN	P51787 KCNQ1; NbExp=4; IntAct=EBI-7043557, EBI-359667; A6HIS0 Tcap (xeno); NbExp=3; IntAct=EBI-7043557, EBI-8784724; 
# IntAct	P15382	4
# InterPro	IPR000369	K_chnl_KCNE
# InterPro	IPR005424	K_chnl_volt-dep_bsu_KCNE1
# KEGG_Brite	ko04040	Ion channels
# KEGG_Disease	H00720	[Cardiovascular disease] Jervell and Lange-Nielsen syndrome (JLNS)
# MIM	176261	gene
# MIM	612347	phenotype
# MIM	613695	phenotype
# Organism	KCNE1_HUMAN	Homo sapiens (Human)
# Orphanet	101016	Romano-Ward syndrome
# Orphanet	334	Familial atrial fibrillation
# Orphanet	90647	Jervell and Lange-Nielsen syndrome
# PDB	2K21	NMR; -; A=1-129
# PIR	A32447	A32447
# PRINTS	PR00168	KCNECHANNEL
# PRINTS	PR01604	KCNE1CHANNEL
# PTM	KCNE1_HUMAN	N-glycosylation at Asn-26 occurs post-translationally, and requires prior cotranslational glycosylation at Asn-5. {ECO 0000269|PubMed 21669976, ECO 0000269|PubMed 21676880}. 
# PTM	KCNE1_HUMAN	Phosphorylation inhibits the potassium current. {ECO 0000250}. 
# Pfam	PF02060	ISK_Channel
# Proteomes	UP000005640	Chromosome 21
# Reactome	R-HSA-5576890	Phase 3 - rapid repolarisation
# Reactome	R-HSA-5576893	Phase 2 - plateau phase
# RecName	KCNE1_HUMAN	Potassium voltage-gated channel subfamily E member 1
# RefSeq	NP_000210	NM_000219.5
# RefSeq	NP_001121140	NM_001127668.3
# RefSeq	NP_001121141	NM_001127669.3
# RefSeq	NP_001121142	NM_001127670.3
# RefSeq	NP_001257331	NM_001270402.2
# RefSeq	NP_001257332	NM_001270403.2
# RefSeq	NP_001257333	NM_001270404.2
# RefSeq	NP_001257334	NM_001270405.2
# SEQUENCE CAUTION	Sequence=AAH36452.1; Type=Erroneous termination; Positions=106; Note=Translated as Cys.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the potassium channel KCNE family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	KCNE1_HUMAN	Cell membrane {ECO 0000269|PubMed 19219384}; Single-pass type I membrane protein {ECO 0000305}. Apical cell membrane {ECO 0000250|UniProtKB P15383}. Membrane raft {ECO 0000269|PubMed 20533308}. Note=Colocalizes with KCNB1 at the plasma membrane (By similarity). Targets to the membrane raft when associated with KNCQ1 (PubMed 20533308). {ECO 0000250|UniProtKB P15383, ECO 0000269|PubMed 20533308}. 
# SUBUNIT	KCNE1_HUMAN	Interacts with KCNB1. Interacts with KCNC2 (By similarity). Associates with KCNH2/HERG (PubMed 9230439). Interacts with KNCQ1; targets the complex KNCQ1-KCNE1 to the membrane raft (PubMed 20533308). {ECO 0000250|UniProtKB P15383, ECO 0000269|PubMed 20533308, ECO 0000269|PubMed 9230439}. 
# TISSUE SPECIFICITY	KCNE1_HUMAN	Expressed in lung, kidney, testis, ovaries, small intestine, peripheral blood leukocytes. Expressed in the heart (PubMed 19219384). Not detected in pancreas, spleen, prostate and colon. Restrictively localized in the apical membrane portion of epithelial cells. {ECO 0000269|PubMed 19219384, ECO 0000269|PubMed 9312006}. 
# UCSC	uc002ytz	human
# eggNOG	ENOG410IY71	Eukaryota
# eggNOG	ENOG410Y1SF	LUCA
BLAST	swissprot:KCNE1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNE1_HUMAN
BioCyc	ZFISH:ENSG00000180509-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000180509-MONOMER
COXPRESdb	3753	http://coxpresdb.jp/data/gene/3753.shtml
CleanEx	HS_KCNE1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNE1
DOI	10.1001/jama.294.23.2975	http://dx.doi.org/10.1001/jama.294.23.2975
DOI	10.1002/humu.20360	http://dx.doi.org/10.1002/humu.20360
DOI	10.1002/jcp.22265	http://dx.doi.org/10.1002/jcp.22265
DOI	10.1006/jmcc.1996.0198	http://dx.doi.org/10.1006/jmcc.1996.0198
DOI	10.1007/s001090100249	http://dx.doi.org/10.1007/s001090100249
DOI	10.1007/s00232-009-9154-8	http://dx.doi.org/10.1007/s00232-009-9154-8
DOI	10.1016/0006-291X(89)91577-5	http://dx.doi.org/10.1016/0006-291X(89)91577-5
DOI	10.1016/0378-1119(94)90685-8	http://dx.doi.org/10.1016/0378-1119(94)90685-8
DOI	10.1016/j.hrthm.2009.05.021	http://dx.doi.org/10.1016/j.hrthm.2009.05.021
DOI	10.1021/bi800875q	http://dx.doi.org/10.1021/bi800875q
DOI	10.1038/40882	http://dx.doi.org/10.1038/40882
DOI	10.1038/ng1197-267	http://dx.doi.org/10.1038/ng1197-267
DOI	10.1038/ng1197-338	http://dx.doi.org/10.1038/ng1197-338
DOI	10.1074/jbc.M111.235168	http://dx.doi.org/10.1074/jbc.M111.235168
DOI	10.1093/emboj/16.17.5472	http://dx.doi.org/10.1093/emboj/16.17.5472
DOI	10.1093/hmg/6.12.2179	http://dx.doi.org/10.1093/hmg/6.12.2179
DOI	10.1093/hmg/8.8.1499	http://dx.doi.org/10.1093/hmg/8.8.1499
DOI	10.1096/fj.01-0520hyp	http://dx.doi.org/10.1096/fj.01-0520hyp
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1113/jphysiol.2011.211284	http://dx.doi.org/10.1113/jphysiol.2011.211284
DOI	10.1161/01.CIR.0000125524.34234.13	http://dx.doi.org/10.1161/01.CIR.0000125524.34234.13
DOI	10.1161/01.CIR.102.10.1178	http://dx.doi.org/10.1161/01.CIR.102.10.1178
DOI	10.1161/01.CIR.97.2.142	http://dx.doi.org/10.1161/01.CIR.97.2.142
DOI	10.1242/jcs.147033	http://dx.doi.org/10.1242/jcs.147033
DrugBank	DB00808	http://www.drugbank.ca/drugs/DB00808
EMBL	AF135188	http://www.ebi.ac.uk/ena/data/view/AF135188
EMBL	BC036452	http://www.ebi.ac.uk/ena/data/view/BC036452
EMBL	DQ784803	http://www.ebi.ac.uk/ena/data/view/DQ784803
EMBL	L28168	http://www.ebi.ac.uk/ena/data/view/L28168
EMBL	L33815	http://www.ebi.ac.uk/ena/data/view/L33815
EMBL	M26685	http://www.ebi.ac.uk/ena/data/view/M26685
Ensembl	ENST00000337385	http://www.ensembl.org/id/ENST00000337385
Ensembl	ENST00000399284	http://www.ensembl.org/id/ENST00000399284
Ensembl	ENST00000399286	http://www.ensembl.org/id/ENST00000399286
Ensembl	ENST00000399289	http://www.ensembl.org/id/ENST00000399289
Ensembl	ENST00000416357	http://www.ensembl.org/id/ENST00000416357
Ensembl	ENST00000432085	http://www.ensembl.org/id/ENST00000432085
Ensembl	ENST00000611936	http://www.ensembl.org/id/ENST00000611936
Ensembl	ENST00000621601	http://www.ensembl.org/id/ENST00000621601
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0030018	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030018
GO_component	GO:0045121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045121
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_function	GO:0015459	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015459
GO_function	GO:0031433	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031433
GO_process	GO:0006487	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006487
GO_process	GO:0006493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006493
GO_process	GO:0007605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007605
GO_process	GO:0060307	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060307
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:0071320	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071320
GO_process	GO:0071435	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071435
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GO_process	GO:0086002	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086002
GO_process	GO:0086005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086005
GO_process	GO:0086009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086009
GO_process	GO:0086011	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086011
GO_process	GO:0086013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086013
GO_process	GO:0086091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086091
GO_process	GO:0090315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090315
GO_process	GO:0098915	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098915
GO_process	GO:1901379	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901379
GO_process	GO:1901381	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901381
GO_process	GO:1902259	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902259
GO_process	GO:1902260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902260
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	KCNE1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNE1
GeneID	3753	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3753
GeneTree	ENSGT00510000048994	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00510000048994
HGNC	HGNC:6240	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6240
HOGENOM	HOG000113207	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000113207&db=HOGENOM6
HOVERGEN	HBG052226	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052226&db=HOVERGEN
InParanoid	P15382	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P15382
IntAct	P15382	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P15382*
InterPro	IPR000369	http://www.ebi.ac.uk/interpro/entry/IPR000369
InterPro	IPR005424	http://www.ebi.ac.uk/interpro/entry/IPR005424
Jabion	3753	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3753
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00720	http://www.genome.jp/dbget-bin/www_bget?H00720
KEGG_Gene	hsa:3753	http://www.genome.jp/dbget-bin/www_bget?hsa:3753
KEGG_Orthology	KO:K04894	http://www.genome.jp/dbget-bin/www_bget?KO:K04894
MIM	176261	http://www.ncbi.nlm.nih.gov/omim/176261
MIM	612347	http://www.ncbi.nlm.nih.gov/omim/612347
MIM	613695	http://www.ncbi.nlm.nih.gov/omim/613695
MINT	MINT-7297782	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-7297782
OMA	ALYILMV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ALYILMV
Orphanet	101016	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=101016
Orphanet	334	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=334
Orphanet	90647	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=90647
OrthoDB	EOG091G0UDJ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0UDJ
PDB	2K21	http://www.ebi.ac.uk/pdbe-srv/view/entry/2K21
PDBsum	2K21	http://www.ebi.ac.uk/pdbsum/2K21
PRINTS	PR00168	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00168
PRINTS	PR01604	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01604
PSORT	swissprot:KCNE1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNE1_HUMAN
PSORT-B	swissprot:KCNE1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNE1_HUMAN
PSORT2	swissprot:KCNE1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNE1_HUMAN
Pfam	PF02060	http://pfam.xfam.org/family/PF02060
PharmGKB	PA211	http://www.pharmgkb.org/do/serve?objId=PA211&objCls=Gene
Phobius	swissprot:KCNE1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNE1_HUMAN
PhylomeDB	P15382	http://phylomedb.org/?seqid=P15382
ProteinModelPortal	P15382	http://www.proteinmodelportal.org/query/uniprot/P15382
PubMed	10400998	http://www.ncbi.nlm.nih.gov/pubmed/10400998
PubMed	10973849	http://www.ncbi.nlm.nih.gov/pubmed/10973849
PubMed	11692163	http://www.ncbi.nlm.nih.gov/pubmed/11692163
PubMed	11874988	http://www.ncbi.nlm.nih.gov/pubmed/11874988
PubMed	15051636	http://www.ncbi.nlm.nih.gov/pubmed/15051636
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16414944	http://www.ncbi.nlm.nih.gov/pubmed/16414944
PubMed	16823764	http://www.ncbi.nlm.nih.gov/pubmed/16823764
PubMed	18611041	http://www.ncbi.nlm.nih.gov/pubmed/18611041
PubMed	19219384	http://www.ncbi.nlm.nih.gov/pubmed/19219384
PubMed	19716085	http://www.ncbi.nlm.nih.gov/pubmed/19716085
PubMed	20533308	http://www.ncbi.nlm.nih.gov/pubmed/20533308
PubMed	21669976	http://www.ncbi.nlm.nih.gov/pubmed/21669976
PubMed	21676880	http://www.ncbi.nlm.nih.gov/pubmed/21676880
PubMed	25037568	http://www.ncbi.nlm.nih.gov/pubmed/25037568
PubMed	2730656	http://www.ncbi.nlm.nih.gov/pubmed/2730656
PubMed	7828904	http://www.ncbi.nlm.nih.gov/pubmed/7828904
PubMed	8899564	http://www.ncbi.nlm.nih.gov/pubmed/8899564
PubMed	9230439	http://www.ncbi.nlm.nih.gov/pubmed/9230439
PubMed	9312006	http://www.ncbi.nlm.nih.gov/pubmed/9312006
PubMed	9328483	http://www.ncbi.nlm.nih.gov/pubmed/9328483
PubMed	9354783	http://www.ncbi.nlm.nih.gov/pubmed/9354783
PubMed	9354802	http://www.ncbi.nlm.nih.gov/pubmed/9354802
PubMed	9445165	http://www.ncbi.nlm.nih.gov/pubmed/9445165
Reactome	R-HSA-5576890	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576890
Reactome	R-HSA-5576893	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576893
RefSeq	NP_000210	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000210
RefSeq	NP_001121140	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001121140
RefSeq	NP_001121141	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001121141
RefSeq	NP_001121142	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001121142
RefSeq	NP_001257331	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001257331
RefSeq	NP_001257332	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001257332
RefSeq	NP_001257333	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001257333
RefSeq	NP_001257334	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001257334
SMR	P15382	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P15382
STRING	9606.ENSP00000337255	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000337255&targetmode=cogs
UCSC	uc002ytz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ytz&org=rat
UniGene	Hs.121495	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.121495
UniGene	Hs.745384	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.745384
UniProtKB	KCNE1_HUMAN	http://www.uniprot.org/uniprot/KCNE1_HUMAN
UniProtKB-AC	P15382	http://www.uniprot.org/uniprot/P15382
charge	swissprot:KCNE1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNE1_HUMAN
eggNOG	ENOG410IY71	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IY71
eggNOG	ENOG410Y1SF	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y1SF
epestfind	swissprot:KCNE1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNE1_HUMAN
garnier	swissprot:KCNE1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNE1_HUMAN
helixturnhelix	swissprot:KCNE1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNE1_HUMAN
hmoment	swissprot:KCNE1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNE1_HUMAN
iep	swissprot:KCNE1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNE1_HUMAN
inforesidue	swissprot:KCNE1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNE1_HUMAN
neXtProt	NX_P15382	http://www.nextprot.org/db/entry/NX_P15382
octanol	swissprot:KCNE1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNE1_HUMAN
pepcoil	swissprot:KCNE1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNE1_HUMAN
pepdigest	swissprot:KCNE1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNE1_HUMAN
pepinfo	swissprot:KCNE1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNE1_HUMAN
pepnet	swissprot:KCNE1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNE1_HUMAN
pepstats	swissprot:KCNE1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNE1_HUMAN
pepwheel	swissprot:KCNE1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNE1_HUMAN
pepwindow	swissprot:KCNE1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNE1_HUMAN
sigcleave	swissprot:KCNE1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNE1_HUMAN
## Database	ID	URL or Descriptions
# AltName	NAC2_HUMAN	Na(+)/Ca(2+)-exchange protein 2
# AltName	NAC2_HUMAN	Solute carrier family 8 member 2
# ChiTaRS	SLC8A2	human
# DOMAIN	NAC2_HUMAN	The cytoplasmic Calx-beta domains bind the regulatory Ca(2+). The first Calx-beta domain can bind up to four Ca(2+) ions. The second domain can bind another two Ca(2+) ions that are essential for calcium-regulated ion exchange. {ECO 0000250|UniProtKB P23685}. 
# ENZYME REGULATION	Calcium transport is down-regulated by Na(+) and stimulated by Ca(2+). {ECO:0000250|UniProtKB	P48768}. 
# Ensembl	ENST00000236877	ENSP00000236877; ENSG00000118160
# ExpressionAtlas	Q9UPR5	baseline and differential
# FUNCTION	NAC2_HUMAN	Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Plays a role in regulating urinary Ca(2+) and Na(+) excretion. {ECO 0000250|UniProtKB Q8K596}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; ISS:UniProtKB.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0043197	dendritic spine; IEA:UniProtKB-SubCell.
# GO_component	GO:0043204	perikaryon; IEA:UniProtKB-SubCell.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_function	NAC2_HUMAN	GO 0005432 calcium sodium antiporter activity; ISS UniProtKB.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006874	cellular calcium ion homeostasis; ISS:UniProtKB.
# GO_process	GO:0007154	cell communication; IEA:InterPro.
# GO_process	GO:0007612	learning; ISS:UniProtKB.
# GO_process	GO:0007613	memory; ISS:UniProtKB.
# GO_process	GO:0035725	sodium ion transmembrane transport; ISS:UniProtKB.
# GO_process	GO:0048172	regulation of short-term neuronal synaptic plasticity; ISS:UniProtKB.
# GO_process	GO:0060291	long-term synaptic potentiation; ISS:UniProtKB.
# GO_process	GO:0070588	calcium ion transmembrane transport; ISS:UniProtKB.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9UPR5	HS
# HGNC	HGNC:11069	SLC8A2
# InterPro	IPR003644	Calx_beta
# InterPro	IPR004836	Na_Ca_Ex
# InterPro	IPR004837	NaCa_Exmemb
# InterPro	IPR032452	Na_Ca_Ex_C-exten
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00536	 Heparan sulfate/heparin binding proteins
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04974	Protein digestion and absorption
# MIM	601901	gene
# Organism	NAC2_HUMAN	Homo sapiens (Human)
# PRINTS	PR01259	NACAEXCHNGR
# Pfam	PF01699	Na_Ca_ex; 2
# Pfam	PF03160	Calx-beta; 2
# Pfam	PF16494	Na_Ca_ex_C
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-418359	Reduction of cytosolic Ca++ levels
# Reactome	R-HSA-425561	Sodium/Calcium exchangers
# Reactome	R-HSA-5578775	Ion homeostasis
# RecName	NAC2_HUMAN	Sodium/calcium exchanger 2
# RefSeq	NP_055878	NM_015063.2
# SEQUENCE CAUTION	Sequence=BAA83039.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 2 Calx-beta domains. {ECO	0000305}. 
# SMART	SM00237	Calx_beta; 2
# SUBCELLULAR LOCATION	NAC2_HUMAN	Cell membrane {ECO 0000250|UniProtKB P48768}; Multi-pass membrane protein {ECO 0000250|UniProtKB P48768}. Basolateral cell membrane {ECO 0000250|UniProtKB Q8K596}; Multi-pass membrane protein {ECO 0000250|UniProtKB Q8K596}. Perikaryon {ECO 0000250|UniProtKB P48768}. Cell projection, dendrite {ECO 0000250|UniProtKB P48768}. Cell projection, dendritic spine {ECO 0000250|UniProtKB P48768}. 
# TCDB	2.A.19.3:the ca(2+)	cation antiporter (caca) family
# TIGRFAMs	TIGR00845	caca
# UCSC	uc002pgx	human
# eggNOG	ENOG410XPJP	LUCA
# eggNOG	KOG1306	Eukaryota
BLAST	swissprot:NAC2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NAC2_HUMAN
BioCyc	ZFISH:ENSG00000118160-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000118160-MONOMER
COXPRESdb	6543	http://coxpresdb.jp/data/gene/6543.shtml
CleanEx	HS_SLC8A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC8A2
DOI	10.1016/j.mam.2012.07.003	http://dx.doi.org/10.1016/j.mam.2012.07.003
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/dnares/6.3.197	http://dx.doi.org/10.1093/dnares/6.3.197
DOI	10.1093/hmg/ddu056	http://dx.doi.org/10.1093/hmg/ddu056
EMBL	AB029010	http://www.ebi.ac.uk/ena/data/view/AB029010
EMBL	AK302552	http://www.ebi.ac.uk/ena/data/view/AK302552
EMBL	CH471126	http://www.ebi.ac.uk/ena/data/view/CH471126
Ensembl	ENST00000236877	http://www.ensembl.org/id/ENST00000236877
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0043197	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043197
GO_component	GO:0043204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043204
GO_function	GO:0005432	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005432
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874
GO_process	GO:0007154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007154
GO_process	GO:0007612	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007612
GO_process	GO:0007613	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007613
GO_process	GO:0035725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035725
GO_process	GO:0048172	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048172
GO_process	GO:0060291	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060291
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC8A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC8A2
GeneID	6543	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6543
GeneTree	ENSGT00730000110414	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00730000110414
HGNC	HGNC:11069	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11069
HOGENOM	HOG000266971	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000266971&db=HOGENOM6
HOVERGEN	HBG006441	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006441&db=HOVERGEN
HPA	HPA050818	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA050818
HPA	HPA054671	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA054671
InParanoid	Q9UPR5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UPR5
InterPro	IPR003644	http://www.ebi.ac.uk/interpro/entry/IPR003644
InterPro	IPR004836	http://www.ebi.ac.uk/interpro/entry/IPR004836
InterPro	IPR004837	http://www.ebi.ac.uk/interpro/entry/IPR004837
InterPro	IPR032452	http://www.ebi.ac.uk/interpro/entry/IPR032452
Jabion	6543	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6543
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00536	http://www.genome.jp/dbget-bin/www_bget?ko00536
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6543	http://www.genome.jp/dbget-bin/www_bget?hsa:6543
KEGG_Orthology	KO:K05849	http://www.genome.jp/dbget-bin/www_bget?KO:K05849
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04974	http://www.genome.jp/kegg-bin/show_pathway?ko04974
MIM	601901	http://www.ncbi.nlm.nih.gov/omim/601901
OMA	AHSQCME	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AHSQCME
OrthoDB	EOG091G0EC1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0EC1
PRINTS	PR01259	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01259
PSORT	swissprot:NAC2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NAC2_HUMAN
PSORT-B	swissprot:NAC2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NAC2_HUMAN
PSORT2	swissprot:NAC2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NAC2_HUMAN
Pfam	PF01699	http://pfam.xfam.org/family/PF01699
Pfam	PF03160	http://pfam.xfam.org/family/PF03160
Pfam	PF16494	http://pfam.xfam.org/family/PF16494
PharmGKB	PA313	http://www.pharmgkb.org/do/serve?objId=PA313&objCls=Gene
Phobius	swissprot:NAC2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NAC2_HUMAN
PhylomeDB	Q9UPR5	http://phylomedb.org/?seqid=Q9UPR5
ProteinModelPortal	Q9UPR5	http://www.proteinmodelportal.org/query/uniprot/Q9UPR5
PubMed	10470851	http://www.ncbi.nlm.nih.gov/pubmed/10470851
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	23506867	http://www.ncbi.nlm.nih.gov/pubmed/23506867
PubMed	24501278	http://www.ncbi.nlm.nih.gov/pubmed/24501278
Reactome	R-HSA-418359	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418359
Reactome	R-HSA-425561	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425561
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
RefSeq	NP_055878	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055878
SMART	SM00237	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00237
SMR	Q9UPR5	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9UPR5
STRING	9606.ENSP00000236877	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000236877&targetmode=cogs
TCDB	2.A.19.3	http://www.tcdb.org/search/result.php?tc=2.A.19.3
TIGRFAMs	TIGR00845	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00845
UCSC	uc002pgx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002pgx&org=rat
UniGene	Hs.172884	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.172884
UniProtKB	NAC2_HUMAN	http://www.uniprot.org/uniprot/NAC2_HUMAN
UniProtKB-AC	Q9UPR5	http://www.uniprot.org/uniprot/Q9UPR5
charge	swissprot:NAC2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NAC2_HUMAN
eggNOG	ENOG410XPJP	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPJP
eggNOG	KOG1306	http://eggnogapi.embl.de/nog_data/html/tree/KOG1306
epestfind	swissprot:NAC2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NAC2_HUMAN
garnier	swissprot:NAC2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NAC2_HUMAN
helixturnhelix	swissprot:NAC2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NAC2_HUMAN
hmoment	swissprot:NAC2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NAC2_HUMAN
iep	swissprot:NAC2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NAC2_HUMAN
inforesidue	swissprot:NAC2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NAC2_HUMAN
neXtProt	NX_Q9UPR5	http://www.nextprot.org/db/entry/NX_Q9UPR5
octanol	swissprot:NAC2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NAC2_HUMAN
pepcoil	swissprot:NAC2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NAC2_HUMAN
pepdigest	swissprot:NAC2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NAC2_HUMAN
pepinfo	swissprot:NAC2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NAC2_HUMAN
pepnet	swissprot:NAC2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NAC2_HUMAN
pepstats	swissprot:NAC2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NAC2_HUMAN
pepwheel	swissprot:NAC2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NAC2_HUMAN
pepwindow	swissprot:NAC2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NAC2_HUMAN
sigcleave	swissprot:NAC2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NAC2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	B3A3_HUMAN	Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist.; Name=BAE3; IsoId=P48751-1; Sequence=Displayed; Name=CAE3; IsoId=P48751-2; Sequence=VSP_000462, VSP_000463; Name=3; IsoId=P48751-3; Sequence=VSP_038184; 
# AltName	B3A3_HUMAN	CAE3/BAE3
# AltName	B3A3_HUMAN	Cardiac/brain band 3-like protein
# AltName	B3A3_HUMAN	Neuronal band 3-like protein
# AltName	B3A3_HUMAN	Solute carrier family 4 member 3
# CCDS	CCDS2445	-. [P48751-1]
# CCDS	CCDS2446	-. [P48751-3]
# ChiTaRS	SLC4A3	human
# Ensembl	ENST00000273063	ENSP00000273063; ENSG00000114923. [P48751-3]
# Ensembl	ENST00000317151	ENSP00000314006; ENSG00000114923. [P48751-1]
# Ensembl	ENST00000358055	ENSP00000350756; ENSG00000114923. [P48751-1]
# Ensembl	ENST00000373760	ENSP00000362865; ENSG00000114923. [P48751-1]
# ExpressionAtlas	P48751	baseline and differential
# FUNCTION	B3A3_HUMAN	Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl(-)/HCO3(-) exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl(-). 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_function	B3A3_HUMAN	GO 0015301 anion anion antiporter activity; IEA UniProtKB-KW.
# GO_function	GO:0005452	inorganic anion exchanger activity; TAS:Reactome.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0015701	bicarbonate transport; TAS:Reactome.
# GO_process	GO:0051453	regulation of intracellular pH; IBA:GO_Central.
# GO_process	GO:1902476	chloride transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.1100.10	-; 1.
# Genevisible	P48751	HS
# HGNC	HGNC:11029	SLC4A3
# InterPro	IPR001717	Anion_exchange
# InterPro	IPR002979	Anion_exchange_3
# InterPro	IPR003020	HCO3_transpt_euk
# InterPro	IPR011531	HCO3_transpt_C
# InterPro	IPR013769	Band3_cytoplasmic_dom
# InterPro	IPR016152	PTrfase/Anion_transptr
# InterPro	IPR018241	Anion_exchange_CS
# KEGG_Brite	ko02001	Solute carrier family
# MIM	106195	gene
# Organism	B3A3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11453	PTHR11453; 2
# PANTHER	PTHR11453:SF15	PTHR11453:SF15; 2
# PIR	I38496	I38496
# PRINTS	PR00165	ANIONEXCHNGR
# PRINTS	PR01189	ANIONEXHNGR3
# PRINTS	PR01231	HCO3TRNSPORT
# PROSITE	PS00219	ANION_EXCHANGER_1
# PROSITE	PS00220	ANION_EXCHANGER_2
# Pfam	PF00955	HCO3_cotransp
# Pfam	PF07565	Band_3_cyto
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-425381	Bicarbonate transporters
# RecName	B3A3_HUMAN	Anion exchange protein 3
# RefSeq	NP_001313488	NM_001326559.1
# RefSeq	NP_005061	NM_005070.3
# RefSeq	NP_963868	NM_201574.2
# RefSeq	XP_005246846	XM_005246789.4. [P48751-3]
# SIMILARITY	Belongs to the anion exchanger (TC 2.A.31) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	B3A3_HUMAN	Membrane; Multi-pass membrane protein. 
# SUPFAM	SSF55804	SSF55804; 2
# TCDB	2.A.31.1	the anion exchanger (ae) family
# TIGRFAMs	TIGR00834	ae
# TISSUE SPECIFICITY	B3A3_HUMAN	Both BAE3 and CAE3 are expressed in failing ventricle. 
# UCSC	uc002vmo	human. [P48751-1]
# eggNOG	ENOG410XPHD	LUCA
# eggNOG	KOG1172	Eukaryota
BLAST	swissprot:B3A3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:B3A3_HUMAN
BioCyc	ZFISH:ENSG00000114923-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000114923-MONOMER
COXPRESdb	6508	http://coxpresdb.jp/data/gene/6508.shtml
CleanEx	HS_SLC4A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC4A3
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1161/01.RES.75.4.603	http://dx.doi.org/10.1161/01.RES.75.4.603
EMBL	AC009955	http://www.ebi.ac.uk/ena/data/view/AC009955
EMBL	AK289974	http://www.ebi.ac.uk/ena/data/view/AK289974
EMBL	AY142112	http://www.ebi.ac.uk/ena/data/view/AY142112
EMBL	BC136384	http://www.ebi.ac.uk/ena/data/view/BC136384
EMBL	BC146656	http://www.ebi.ac.uk/ena/data/view/BC146656
EMBL	BC171760	http://www.ebi.ac.uk/ena/data/view/BC171760
EMBL	CH471063	http://www.ebi.ac.uk/ena/data/view/CH471063
EMBL	L27213	http://www.ebi.ac.uk/ena/data/view/L27213
EMBL	U05596	http://www.ebi.ac.uk/ena/data/view/U05596
Ensembl	ENST00000273063	http://www.ensembl.org/id/ENST00000273063
Ensembl	ENST00000317151	http://www.ensembl.org/id/ENST00000317151
Ensembl	ENST00000358055	http://www.ensembl.org/id/ENST00000358055
Ensembl	ENST00000373760	http://www.ensembl.org/id/ENST00000373760
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0005452	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005452
GO_function	GO:0015301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015301
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0015701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015701
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.1100.10	http://www.cathdb.info/version/latest/superfamily/3.40.1100.10
GeneCards	SLC4A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC4A3
GeneID	6508	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6508
GeneTree	ENSGT00760000119021	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119021
HGNC	HGNC:11029	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11029
HOGENOM	HOG000280683	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280683&db=HOGENOM6
HOVERGEN	HBG004326	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004326&db=HOVERGEN
HPA	HPA040315	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA040315
InParanoid	P48751	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P48751
InterPro	IPR001717	http://www.ebi.ac.uk/interpro/entry/IPR001717
InterPro	IPR002979	http://www.ebi.ac.uk/interpro/entry/IPR002979
InterPro	IPR003020	http://www.ebi.ac.uk/interpro/entry/IPR003020
InterPro	IPR011531	http://www.ebi.ac.uk/interpro/entry/IPR011531
InterPro	IPR013769	http://www.ebi.ac.uk/interpro/entry/IPR013769
InterPro	IPR016152	http://www.ebi.ac.uk/interpro/entry/IPR016152
InterPro	IPR018241	http://www.ebi.ac.uk/interpro/entry/IPR018241
Jabion	6508	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6508
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6508	http://www.genome.jp/dbget-bin/www_bget?hsa:6508
KEGG_Orthology	KO:K13856	http://www.genome.jp/dbget-bin/www_bget?KO:K13856
MIM	106195	http://www.ncbi.nlm.nih.gov/omim/106195
OMA	KSPQHSV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KSPQHSV
OrthoDB	EOG091G01FT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01FT
PANTHER	PTHR11453	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11453
PANTHER	PTHR11453:SF15	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11453:SF15
PRINTS	PR00165	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00165
PRINTS	PR01189	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01189
PRINTS	PR01231	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01231
PROSITE	PS00219	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00219
PROSITE	PS00220	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00220
PSORT	swissprot:B3A3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:B3A3_HUMAN
PSORT-B	swissprot:B3A3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:B3A3_HUMAN
PSORT2	swissprot:B3A3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:B3A3_HUMAN
Pfam	PF00955	http://pfam.xfam.org/family/PF00955
Pfam	PF07565	http://pfam.xfam.org/family/PF07565
PharmGKB	PA35897	http://www.pharmgkb.org/do/serve?objId=PA35897&objCls=Gene
Phobius	swissprot:B3A3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:B3A3_HUMAN
PhylomeDB	P48751	http://phylomedb.org/?seqid=P48751
ProteinModelPortal	P48751	http://www.proteinmodelportal.org/query/uniprot/P48751
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	7923606	http://www.ncbi.nlm.nih.gov/pubmed/7923606
Reactome	R-HSA-425381	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425381
RefSeq	NP_001313488	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001313488
RefSeq	NP_005061	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005061
RefSeq	NP_963868	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_963868
RefSeq	XP_005246846	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005246846
SMR	P48751	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P48751
STRING	9606.ENSP00000273063	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000273063&targetmode=cogs
SUPFAM	SSF55804	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55804
TCDB	2.A.31.1	http://www.tcdb.org/search/result.php?tc=2.A.31.1
TIGRFAMs	TIGR00834	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00834
UCSC	uc002vmo	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002vmo&org=rat
UniGene	Hs.1176	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.1176
UniGene	Hs.684906	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.684906
UniProtKB	B3A3_HUMAN	http://www.uniprot.org/uniprot/B3A3_HUMAN
UniProtKB-AC	P48751	http://www.uniprot.org/uniprot/P48751
charge	swissprot:B3A3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:B3A3_HUMAN
eggNOG	ENOG410XPHD	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPHD
eggNOG	KOG1172	http://eggnogapi.embl.de/nog_data/html/tree/KOG1172
epestfind	swissprot:B3A3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:B3A3_HUMAN
garnier	swissprot:B3A3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:B3A3_HUMAN
helixturnhelix	swissprot:B3A3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:B3A3_HUMAN
hmoment	swissprot:B3A3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:B3A3_HUMAN
iep	swissprot:B3A3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:B3A3_HUMAN
inforesidue	swissprot:B3A3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:B3A3_HUMAN
neXtProt	NX_P48751	http://www.nextprot.org/db/entry/NX_P48751
octanol	swissprot:B3A3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:B3A3_HUMAN
pepcoil	swissprot:B3A3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:B3A3_HUMAN
pepdigest	swissprot:B3A3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:B3A3_HUMAN
pepinfo	swissprot:B3A3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:B3A3_HUMAN
pepnet	swissprot:B3A3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:B3A3_HUMAN
pepstats	swissprot:B3A3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:B3A3_HUMAN
pepwheel	swissprot:B3A3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:B3A3_HUMAN
pepwindow	swissprot:B3A3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:B3A3_HUMAN
sigcleave	swissprot:B3A3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:B3A3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	EMB_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PCB8-1; Sequence=Displayed; Name=2; IsoId=Q6PCB8-2; Sequence=VSP_055593; Note=No experimental confirmation available.; 
# BioGrid	126358	12
# CCDS	CCDS3953	-. [Q6PCB8-1]
# ChiTaRS	EMB	human
# Ensembl	ENST00000303221	ENSP00000302289; ENSG00000170571. [Q6PCB8-1]
# Ensembl	ENST00000514111	ENSP00000426404; ENSG00000170571. [Q6PCB8-2]
# ExpressionAtlas	Q6PCB8	baseline and differential
# FUNCTION	EMB_HUMAN	Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane (By similarity). {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; ISS:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0045202	synapse; IEA:UniProtKB-SubCell.
# GO_function	GO:0008028	monocarboxylic acid transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0035879	plasma membrane lactate transport; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.40.10	-; 2.
# Genevisible	Q6PCB8	HS
# HGNC	HGNC:30465	EMB
# InterPro	IPR003599	Ig_sub
# InterPro	IPR007110	Ig-like_dom
# InterPro	IPR013098	Ig_I-set
# InterPro	IPR013151	Immunoglobulin
# InterPro	IPR013783	Ig-like_fold
# InterPro	IPR027114	Embigin
# MIM	615669	gene
# Organism	EMB_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10075:SF4	PTHR10075:SF4
# PROSITE	PS50835	IG_LIKE; 2
# Pfam	PF00047	ig
# Pfam	PF07679	I-set
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-433692	Proton-coupled monocarboxylate transport
# RecName	EMB_HUMAN	Embigin
# RefSeq	NP_940851	NM_198449.2. [Q6PCB8-1]
# RefSeq	XP_011541448	XM_011543146.2. [Q6PCB8-2]
# SIMILARITY	Contains 2 Ig-like V-type (immunoglobulin-like) domains. {ECO	0000305}.
# SMART	SM00409	IG; 2
# SUBCELLULAR LOCATION	EMB_HUMAN	Cell membrane {ECO 0000250|UniProtKB O88775}; Single-pass type I membrane protein {ECO 0000250|UniProtKB O88775}. Cell junction, synapse {ECO 0000250|UniProtKB P21995}. Note=Localizes to the neuromuscular junctions. {ECO 0000250|UniProtKB P21995}. 
# SUBUNIT	Interacts with SLC16A1 and SLC16A7. {ECO	0000250}. 
# SUPFAM	SSF48726	SSF48726; 2
# TCDB	8.A.23.1	the basigin (basigin) family
# UCSC	uc003jom	human. [Q6PCB8-1]
# eggNOG	ENOG410IVBC	Eukaryota
# eggNOG	ENOG41120A3	LUCA
BLAST	swissprot:EMB_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:EMB_HUMAN
COXPRESdb	133418	http://coxpresdb.jp/data/gene/133418.shtml
CleanEx	HS_EMB	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_EMB
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1038/nbt.1532	http://dx.doi.org/10.1038/nbt.1532
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC035145	http://www.ebi.ac.uk/ena/data/view/AC035145
EMBL	AC091833	http://www.ebi.ac.uk/ena/data/view/AC091833
EMBL	AK300860	http://www.ebi.ac.uk/ena/data/view/AK300860
EMBL	AK304226	http://www.ebi.ac.uk/ena/data/view/AK304226
EMBL	BC059398	http://www.ebi.ac.uk/ena/data/view/BC059398
EMBL	CH471123	http://www.ebi.ac.uk/ena/data/view/CH471123
EMBL	CH471123	http://www.ebi.ac.uk/ena/data/view/CH471123
Ensembl	ENST00000303221	http://www.ensembl.org/id/ENST00000303221
Ensembl	ENST00000514111	http://www.ensembl.org/id/ENST00000514111
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0045202	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045202
GO_function	GO:0008028	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008028
GO_process	GO:0035879	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035879
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.40.10	http://www.cathdb.info/version/latest/superfamily/2.60.40.10
GeneCards	EMB	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=EMB
GeneID	133418	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=133418
GeneTree	ENSGT00390000010516	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000010516
HGNC	HGNC:30465	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:30465
HOGENOM	HOG000082417	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000082417&db=HOGENOM6
HOVERGEN	HBG051471	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051471&db=HOVERGEN
HPA	HPA017740	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA017740
InParanoid	Q6PCB8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6PCB8
InterPro	IPR003599	http://www.ebi.ac.uk/interpro/entry/IPR003599
InterPro	IPR007110	http://www.ebi.ac.uk/interpro/entry/IPR007110
InterPro	IPR013098	http://www.ebi.ac.uk/interpro/entry/IPR013098
InterPro	IPR013151	http://www.ebi.ac.uk/interpro/entry/IPR013151
InterPro	IPR013783	http://www.ebi.ac.uk/interpro/entry/IPR013783
InterPro	IPR027114	http://www.ebi.ac.uk/interpro/entry/IPR027114
Jabion	133418	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=133418
KEGG_Gene	hsa:133418	http://www.genome.jp/dbget-bin/www_bget?hsa:133418
MIM	615669	http://www.ncbi.nlm.nih.gov/omim/615669
OMA	SKQMGSY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SKQMGSY
OrthoDB	EOG091G0RFU	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0RFU
PANTHER	PTHR10075:SF4	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10075:SF4
PROSITE	PS50835	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50835
PSORT	swissprot:EMB_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:EMB_HUMAN
PSORT-B	swissprot:EMB_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:EMB_HUMAN
PSORT2	swissprot:EMB_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:EMB_HUMAN
Pfam	PF00047	http://pfam.xfam.org/family/PF00047
Pfam	PF07679	http://pfam.xfam.org/family/PF07679
PharmGKB	PA134917460	http://www.pharmgkb.org/do/serve?objId=PA134917460&objCls=Gene
Phobius	swissprot:EMB_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:EMB_HUMAN
PhylomeDB	Q6PCB8	http://phylomedb.org/?seqid=Q6PCB8
ProteinModelPortal	Q6PCB8	http://www.proteinmodelportal.org/query/uniprot/Q6PCB8
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19349973	http://www.ncbi.nlm.nih.gov/pubmed/19349973
Reactome	R-HSA-433692	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-433692
RefSeq	NP_940851	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_940851
RefSeq	XP_011541448	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011541448
SMART	SM00409	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00409
STRING	9606.ENSP00000302289	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000302289&targetmode=cogs
SUPFAM	SSF48726	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48726
TCDB	8.A.23.1	http://www.tcdb.org/search/result.php?tc=8.A.23.1
UCSC	uc003jom	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003jom&org=rat
UniGene	Hs.561411	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.561411
UniProtKB	EMB_HUMAN	http://www.uniprot.org/uniprot/EMB_HUMAN
UniProtKB-AC	Q6PCB8	http://www.uniprot.org/uniprot/Q6PCB8
charge	swissprot:EMB_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:EMB_HUMAN
eggNOG	ENOG410IVBC	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IVBC
eggNOG	ENOG41120A3	http://eggnogapi.embl.de/nog_data/html/tree/ENOG41120A3
epestfind	swissprot:EMB_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:EMB_HUMAN
garnier	swissprot:EMB_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:EMB_HUMAN
helixturnhelix	swissprot:EMB_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:EMB_HUMAN
hmoment	swissprot:EMB_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:EMB_HUMAN
iep	swissprot:EMB_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:EMB_HUMAN
inforesidue	swissprot:EMB_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:EMB_HUMAN
neXtProt	NX_Q6PCB8	http://www.nextprot.org/db/entry/NX_Q6PCB8
octanol	swissprot:EMB_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:EMB_HUMAN
pepcoil	swissprot:EMB_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:EMB_HUMAN
pepdigest	swissprot:EMB_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:EMB_HUMAN
pepinfo	swissprot:EMB_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:EMB_HUMAN
pepnet	swissprot:EMB_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:EMB_HUMAN
pepstats	swissprot:EMB_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:EMB_HUMAN
pepwheel	swissprot:EMB_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:EMB_HUMAN
pepwindow	swissprot:EMB_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:EMB_HUMAN
sigcleave	swissprot:EMB_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:EMB_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S36A4_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6YBV0-1; Sequence=Displayed; Name=2; IsoId=Q6YBV0-2; Sequence=VSP_028959; Note=No experimental confirmation available.; 
# AltName	S36A4_HUMAN	Solute carrier family 36 member 4
# BIOPHYSICOCHEMICAL PROPERTIES	S36A4_HUMAN	Kinetic parameters  KM=3.1 uM for L-proline {ECO 0000269|PubMed 21097500}; KM=1.7 uM for L-tryptophan {ECO 0000269|PubMed 21097500}; pH dependence  Optimum pH is 7.4 (for proline transport). {ECO 0000269|PubMed 21097500}; 
# CCDS	CCDS66202	-. [Q6YBV0-2]
# CCDS	CCDS8291	-. [Q6YBV0-1]
# ChiTaRS	SLC36A4	human
# Ensembl	ENST00000326402	ENSP00000317382; ENSG00000180773. [Q6YBV0-1]
# Ensembl	ENST00000529184	ENSP00000436570; ENSG00000180773. [Q6YBV0-2]
# ExpressionAtlas	Q6YBV0	baseline and differential
# FUNCTION	S36A4_HUMAN	Functions as a sodium-independent electroneutral transporter for tryptophan, proline and alanine. Inhibited by sarcosine. {ECO 0000269|PubMed 21097500}. 
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015180	L-alanine transmembrane transporter activity; IDA:WormBase.
# GO_function	GO:0015193	L-proline transmembrane transporter activity; IDA:WormBase.
# GO_function	GO:0015196	L-tryptophan transmembrane transporter activity; IDA:WormBase.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_process	GO:0015808	L-alanine transport; IDA:UniProtKB.
# GO_process	GO:0015824	proline transport; IDA:UniProtKB.
# GO_process	GO:0015827	tryptophan transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q6YBV0	HS
# HGNC	HGNC:19660	SLC36A4
# InterPro	IPR013057	AA_transpt_TM
# KEGG_Brite	ko02001	Solute carrier family
# MIM	613760	gene
# Organism	S36A4_HUMAN	Homo sapiens (Human)
# Pfam	PF01490	Aa_trans
# Proteomes	UP000005640	Chromosome 11
# RecName	S36A4_HUMAN	Proton-coupled amino acid transporter 4
# RefSeq	NP_001273068	NM_001286139.1. [Q6YBV0-2]
# RefSeq	NP_689526	NM_152313.3. [Q6YBV0-1]
# RefSeq	XP_016872665	XM_017017176.1. [Q6YBV0-2]
# SEQUENCE CAUTION	Sequence=CAC82496.1; Type=Frameshift; Positions=358, 361, 363, 366, 370, 373, 376, 387, 396, 458, 487; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the amino acid/polyamine transporter 2 family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S36A4_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	2.A.18.8	the amino acid/auxin permease (aaap) family
# UCSC	uc001pdl	human. [Q6YBV0-1]
# eggNOG	COG0814	LUCA
# eggNOG	KOG1304	Eukaryota
BLAST	swissprot:S36A4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S36A4_HUMAN
COXPRESdb	120103	http://coxpresdb.jp/data/gene/120103.shtml
CleanEx	HS_SLC36A4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC36A4
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1074/jbc.M110.172403	http://dx.doi.org/10.1074/jbc.M110.172403
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AJ295983	http://www.ebi.ac.uk/ena/data/view/AJ295983
EMBL	AK096251	http://www.ebi.ac.uk/ena/data/view/AK096251
EMBL	AY162216	http://www.ebi.ac.uk/ena/data/view/AY162216
EMBL	BC047374	http://www.ebi.ac.uk/ena/data/view/BC047374
Ensembl	ENST00000326402	http://www.ensembl.org/id/ENST00000326402
Ensembl	ENST00000529184	http://www.ensembl.org/id/ENST00000529184
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015180	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015180
GO_function	GO:0015193	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015193
GO_function	GO:0015196	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015196
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_process	GO:0015808	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015808
GO_process	GO:0015824	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015824
GO_process	GO:0015827	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015827
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC36A4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC36A4
GeneID	120103	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=120103
GeneTree	ENSGT00390000011245	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000011245
HGNC	HGNC:19660	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:19660
HOGENOM	HOG000006823	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006823&db=HOGENOM6
HOVERGEN	HBG057183	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG057183&db=HOVERGEN
HPA	HPA017887	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA017887
InParanoid	Q6YBV0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6YBV0
IntAct	Q6YBV0	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q6YBV0*
InterPro	IPR013057	http://www.ebi.ac.uk/interpro/entry/IPR013057
Jabion	120103	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=120103
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:120103	http://www.genome.jp/dbget-bin/www_bget?hsa:120103
KEGG_Orthology	KO:K14209	http://www.genome.jp/dbget-bin/www_bget?KO:K14209
MIM	613760	http://www.ncbi.nlm.nih.gov/omim/613760
OMA	ILTFSKE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ILTFSKE
OrthoDB	EOG091G079T	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G079T
PSORT	swissprot:S36A4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S36A4_HUMAN
PSORT-B	swissprot:S36A4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S36A4_HUMAN
PSORT2	swissprot:S36A4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S36A4_HUMAN
Pfam	PF01490	http://pfam.xfam.org/family/PF01490
PharmGKB	PA134908925	http://www.pharmgkb.org/do/serve?objId=PA134908925&objCls=Gene
Phobius	swissprot:S36A4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S36A4_HUMAN
PhylomeDB	Q6YBV0	http://phylomedb.org/?seqid=Q6YBV0
ProteinModelPortal	Q6YBV0	http://www.proteinmodelportal.org/query/uniprot/Q6YBV0
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21097500	http://www.ncbi.nlm.nih.gov/pubmed/21097500
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
RefSeq	NP_001273068	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273068
RefSeq	NP_689526	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_689526
RefSeq	XP_016872665	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016872665
STRING	9606.ENSP00000317382	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000317382&targetmode=cogs
TCDB	2.A.18.8	http://www.tcdb.org/search/result.php?tc=2.A.18.8
UCSC	uc001pdl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001pdl&org=rat
UniGene	Hs.148766	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.148766
UniGene	Hs.596383	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.596383
UniProtKB	S36A4_HUMAN	http://www.uniprot.org/uniprot/S36A4_HUMAN
UniProtKB-AC	Q6YBV0	http://www.uniprot.org/uniprot/Q6YBV0
charge	swissprot:S36A4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S36A4_HUMAN
eggNOG	COG0814	http://eggnogapi.embl.de/nog_data/html/tree/COG0814
eggNOG	KOG1304	http://eggnogapi.embl.de/nog_data/html/tree/KOG1304
epestfind	swissprot:S36A4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S36A4_HUMAN
garnier	swissprot:S36A4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S36A4_HUMAN
helixturnhelix	swissprot:S36A4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S36A4_HUMAN
hmoment	swissprot:S36A4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S36A4_HUMAN
iep	swissprot:S36A4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S36A4_HUMAN
inforesidue	swissprot:S36A4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S36A4_HUMAN
neXtProt	NX_Q6YBV0	http://www.nextprot.org/db/entry/NX_Q6YBV0
octanol	swissprot:S36A4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S36A4_HUMAN
pepcoil	swissprot:S36A4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S36A4_HUMAN
pepdigest	swissprot:S36A4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S36A4_HUMAN
pepinfo	swissprot:S36A4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S36A4_HUMAN
pepnet	swissprot:S36A4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S36A4_HUMAN
pepstats	swissprot:S36A4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S36A4_HUMAN
pepwheel	swissprot:S36A4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S36A4_HUMAN
pepwindow	swissprot:S36A4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S36A4_HUMAN
sigcleave	swissprot:S36A4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S36A4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	NCKX5_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q71RS6-1; Sequence=Displayed; Name=2; IsoId=Q71RS6-2; Sequence=VSP_047596; 
# AltName	NCKX5_HUMAN	Na(+)/K(+)/Ca(2+)-exchange protein 5
# AltName	NCKX5_HUMAN	Solute carrier family 24 member 5
# BioGrid	129632	3
# CCDS	CCDS10128	-. [Q71RS6-1]
# ChiTaRS	SLC24A5	human
# DISEASE	NCKX5_HUMAN	Albinism, oculocutaneous, 6 (OCA6) [MIM 113750]  A disorder characterized by a reduction or complete loss of melanin in the skin, hair and eyes. Patients show reduced or lacking pigmentation often accompanied by eye symptoms such as photophobia, strabismus, moderate to severe visual impairment, and nystagmus. {ECO 0000269|PubMed 23364476}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000341459	ENSP00000341550; ENSG00000188467. [Q71RS6-1]
# Ensembl	ENST00000449382	ENSP00000389966; ENSG00000188467. [Q71RS6-2]
# ExpressionAtlas	Q71RS6	baseline and differential
# FUNCTION	NCKX5_HUMAN	Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium- Calcium exchanger in melanocytes. Probably transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). {ECO 0000269|PubMed 16357253, ECO 0000269|PubMed 18166528}. 
# GO_component	GO:0005802	trans-Golgi network; IDA:MGI.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0032588	trans-Golgi network membrane; TAS:Reactome.
# GO_component	GO:0042470	melanosome; IEA:UniProtKB-SubCell.
# GO_function	GO:0005262	calcium channel activity; IBA:GO_Central.
# GO_function	GO:0005509	calcium ion binding; IBA:GO_Central.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_function	GO:0030955	potassium ion binding; IBA:GO_Central.
# GO_function	GO:0031402	sodium ion binding; IBA:GO_Central.
# GO_function	NCKX5_HUMAN	GO 0008273 calcium, potassium sodium antiporter activity; IDA MGI.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006874	cellular calcium ion homeostasis; IBA:GO_Central.
# GO_process	GO:0034220	ion transmembrane transport; IDA:MGI.
# GO_process	GO:0048022	negative regulation of melanin biosynthetic process; IEA:Ensembl.
# GO_process	GO:0050896	response to stimulus; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# HGNC	HGNC:20611	SLC24A5
# InterPro	IPR004481	K/Na/Ca-exchanger
# InterPro	IPR004837	NaCa_Exmemb
# InterPro	IPR030245	SLC24A5
# KEGG_Brite	ko02001	Solute carrier family
# MIM	113750	phenotype
# MIM	609802	gene
# Organism	NCKX5_HUMAN	Homo sapiens (Human)
# Orphanet	370097	Oculocutaneous albinism type 6
# PANTHER	PTHR10846	PTHR10846
# PANTHER	PTHR10846:SF27	PTHR10846:SF27
# POLYMORPHISM	Genetic variants in SLC24A5 define the skin/hair/eye pigmentation variation locus 4 (SHEP4) [MIM:113750]. Hair, eye and skin pigmentation are among the most visible examples of human phenotypic variation, with a broad normal range that is subject to substantial geographic stratification. In the case of skin, individuals tend to have lighter pigmentation with increasing distance from the equator. By contrast, the majority of variation in human eye and hair color is found among individuals of European ancestry, with most other human populations fixed for brown eyes and black hair. {ECO	0000269|PubMed:17999355}. 
# POLYMORPHISM	The Ala-111 allele predominates (93 to 100%) in African and East Asian populations. In contrast, the Thr-111 allele is nearly fixed (98.7 to 100%) in European populations, is associated with a substantial reduction in regional heterozygosity, and correlates with lighter skin pigmentation in admixed populations. {ECO:0000269|PubMed	17999355}. 
# Pfam	PF01699	Na_Ca_ex; 2
# Proteomes	UP000005640	Chromosome 15
# Reactome	R-HSA-425561	Sodium/Calcium exchangers
# RecName	NCKX5_HUMAN	Sodium/potassium/calcium exchanger 5
# RefSeq	NP_995322	NM_205850.2. [Q71RS6-1]
# SIMILARITY	Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	NCKX5_HUMAN	Golgi apparatus, trans-Golgi network membrane {ECO 0000269|PubMed 18166528}; Multi-pass membrane protein {ECO 0000269|PubMed 18166528}. Melanosome {ECO 0000269|PubMed 17081065}. Note=Enriched in late-stage melanosomes (PubMed 17081065). 
# TCDB	2.A.19.4:the ca(2+)	cation antiporter (caca) family
# TIGRFAMs	TIGR00367	TIGR00367
# UCSC	uc001zwe	human. [Q71RS6-1]
# WEB RESOURCE	NCKX5_HUMAN	Name=Protein Spotlight; Note=Skin-deep - Issue 74 of September 2006; URL="http //web.expasy.org/spotlight/back_issues/074";
# eggNOG	ENOG410Y9YY	LUCA
# eggNOG	KOG1307	Eukaryota
BLAST	swissprot:NCKX5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NCKX5_HUMAN
BioCyc	ZFISH:G66-32021-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32021-MONOMER
COXPRESdb	283652	http://coxpresdb.jp/data/gene/283652.shtml
CleanEx	HS_SLC24A5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC24A5
DOI	10.1021/pr060363j	http://dx.doi.org/10.1021/pr060363j
DOI	10.1038/jid.2013.49	http://dx.doi.org/10.1038/jid.2013.49
DOI	10.1038/nature04601	http://dx.doi.org/10.1038/nature04601
DOI	10.1074/jbc.M707521200	http://dx.doi.org/10.1074/jbc.M707521200
DOI	10.1086/522235	http://dx.doi.org/10.1086/522235
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1116238	http://dx.doi.org/10.1126/science.1116238
EMBL	AC090526	http://www.ebi.ac.uk/ena/data/view/AC090526
EMBL	AF348468	http://www.ebi.ac.uk/ena/data/view/AF348468
EMBL	BC073944	http://www.ebi.ac.uk/ena/data/view/BC073944
EMBL	BC113628	http://www.ebi.ac.uk/ena/data/view/BC113628
EMBL	BC113630	http://www.ebi.ac.uk/ena/data/view/BC113630
EMBL	BC143950	http://www.ebi.ac.uk/ena/data/view/BC143950
EMBL	DQ665306	http://www.ebi.ac.uk/ena/data/view/DQ665306
EMBL	DQ665307	http://www.ebi.ac.uk/ena/data/view/DQ665307
Ensembl	ENST00000341459	http://www.ensembl.org/id/ENST00000341459
Ensembl	ENST00000449382	http://www.ensembl.org/id/ENST00000449382
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005802	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005802
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0032588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032588
GO_component	GO:0042470	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042470
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0008273	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008273
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_function	GO:0030955	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030955
GO_function	GO:0031402	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031402
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0048022	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048022
GO_process	GO:0050896	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050896
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC24A5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC24A5
GeneID	283652	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=283652
GeneTree	ENSGT00760000119209	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119209
H-InvDB	HIX0012216	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0012216
HGNC	HGNC:20611	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20611
HOGENOM	HOG000231933	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231933&db=HOGENOM6
HOVERGEN	HBG054881	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054881&db=HOVERGEN
InParanoid	Q71RS6	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q71RS6
IntAct	Q71RS6	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q71RS6*
InterPro	IPR004481	http://www.ebi.ac.uk/interpro/entry/IPR004481
InterPro	IPR004837	http://www.ebi.ac.uk/interpro/entry/IPR004837
InterPro	IPR030245	http://www.ebi.ac.uk/interpro/entry/IPR030245
Jabion	283652	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=283652
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:283652	http://www.genome.jp/dbget-bin/www_bget?hsa:283652
KEGG_Orthology	KO:K13753	http://www.genome.jp/dbget-bin/www_bget?KO:K13753
MIM	113750	http://www.ncbi.nlm.nih.gov/omim/113750
MIM	609802	http://www.ncbi.nlm.nih.gov/omim/609802
OMA	CSPCCAC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CSPCCAC
Orphanet	370097	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=370097
OrthoDB	EOG091G0M5C	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0M5C
PANTHER	PTHR10846	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10846
PANTHER	PTHR10846:SF27	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10846:SF27
PSORT	swissprot:NCKX5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NCKX5_HUMAN
PSORT-B	swissprot:NCKX5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NCKX5_HUMAN
PSORT2	swissprot:NCKX5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NCKX5_HUMAN
Pfam	PF01699	http://pfam.xfam.org/family/PF01699
PharmGKB	PA134868972	http://www.pharmgkb.org/do/serve?objId=PA134868972&objCls=Gene
Phobius	swissprot:NCKX5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NCKX5_HUMAN
PhylomeDB	Q71RS6	http://phylomedb.org/?seqid=Q71RS6
ProteinModelPortal	Q71RS6	http://www.proteinmodelportal.org/query/uniprot/Q71RS6
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16357253	http://www.ncbi.nlm.nih.gov/pubmed/16357253
PubMed	16572171	http://www.ncbi.nlm.nih.gov/pubmed/16572171
PubMed	17081065	http://www.ncbi.nlm.nih.gov/pubmed/17081065
PubMed	17999355	http://www.ncbi.nlm.nih.gov/pubmed/17999355
PubMed	18166528	http://www.ncbi.nlm.nih.gov/pubmed/18166528
PubMed	23364476	http://www.ncbi.nlm.nih.gov/pubmed/23364476
Reactome	R-HSA-425561	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425561
RefSeq	NP_995322	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_995322
STRING	9606.ENSP00000341550	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000341550&targetmode=cogs
TCDB	2.A.19.4	http://www.tcdb.org/search/result.php?tc=2.A.19.4
TIGRFAMs	TIGR00367	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00367
UCSC	uc001zwe	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001zwe&org=rat
UniGene	Hs.710240	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.710240
UniProtKB	NCKX5_HUMAN	http://www.uniprot.org/uniprot/NCKX5_HUMAN
UniProtKB-AC	Q71RS6	http://www.uniprot.org/uniprot/Q71RS6
charge	swissprot:NCKX5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NCKX5_HUMAN
eggNOG	ENOG410Y9YY	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y9YY
eggNOG	KOG1307	http://eggnogapi.embl.de/nog_data/html/tree/KOG1307
epestfind	swissprot:NCKX5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NCKX5_HUMAN
garnier	swissprot:NCKX5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NCKX5_HUMAN
helixturnhelix	swissprot:NCKX5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NCKX5_HUMAN
hmoment	swissprot:NCKX5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NCKX5_HUMAN
iep	swissprot:NCKX5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NCKX5_HUMAN
inforesidue	swissprot:NCKX5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NCKX5_HUMAN
neXtProt	NX_Q71RS6	http://www.nextprot.org/db/entry/NX_Q71RS6
octanol	swissprot:NCKX5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NCKX5_HUMAN
pepcoil	swissprot:NCKX5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NCKX5_HUMAN
pepdigest	swissprot:NCKX5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NCKX5_HUMAN
pepinfo	swissprot:NCKX5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NCKX5_HUMAN
pepnet	swissprot:NCKX5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NCKX5_HUMAN
pepstats	swissprot:NCKX5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NCKX5_HUMAN
pepwheel	swissprot:NCKX5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NCKX5_HUMAN
pepwindow	swissprot:NCKX5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NCKX5_HUMAN
sigcleave	swissprot:NCKX5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NCKX5_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNA2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P16389-1; Sequence=Displayed; Name=2; IsoId=P16389-2; Sequence=VSP_043077; Note=No experimental confirmation available.; 
# AltName	KCNA2_HUMAN	NGK1
# AltName	KCNA2_HUMAN	Voltage-gated potassium channel HBK5
# AltName	KCNA2_HUMAN	Voltage-gated potassium channel subunit Kv1.2
# AltName	Voltage-gated K(+) channel HuKIV {ECO:0000303|PubMed	19912772}
# BIOPHYSICOCHEMICAL PROPERTIES	Kinetic parameters: Note=Homotetrameric channels activate rapidly, i.e within a few msec, but inactivation is very slow, with only a marginal decrease in conductance over several seconds. The voltage- dependence of activation and inactivation and other channel characteristics vary depending on the experimental conditions, the expression system, post-translational modifications and the presence or absence of ancillary subunits. For the activation of homotetrameric channels expressed in xenopus oocytes, the threshold is at about -30 mV and the midpoint at about -5 mV. {ECO	0000269|PubMed:19912772}; 
# BioGrid	109940	17
# CCDS	CCDS55625	-. [P16389-2]
# CCDS	CCDS827	-. [P16389-1]
# DISEASE	KCNA2_HUMAN	Epileptic encephalopathy, early infantile, 32 (EIEE32) [MIM 616366]  A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. {ECO 0000269|PubMed 25477152, ECO 0000269|PubMed 25751627}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	KCNA2_HUMAN	The cytoplasmic N-terminus is important for tetramerization. Interactions between the different subunits modulate the gating characteristics (By similarity). Besides, the cytoplasmic N-terminal domain mediates interaction with RHOA and thus is required for RHOA-mediated endocytosis (By similarity). {ECO 0000250|UniProtKB P63142}. 
# DOMAIN	KCNA2_HUMAN	The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. {ECO 0000250|UniProtKB P63142}. 
# DrugBank	DB06637	Dalfampridine
# ENZYME REGULATION	KCNA2_HUMAN	Inhibited by 4-aminopyridine (4-AP) and charybdotoxin (CTX), but not by tetraethylammonium (TEA) (PubMed 19912772). Inhibited by dendrotoxin (DTX) (By similarity). Inhibited by tityustoxin-K alpha (TsTX-Kalpha), a toxin that is highly specific for KCNA2 (By similarity). Inhibited by maurotoxin (By similarity). Inhibited by kappaM conotoxins kappaM-RIIIJ and kappaM-RIIIK; kappaM-RIIIJ has much higher affinity for channels containing KCNA2 than kappaM-RIIIK, with the exception of heterodimers formed by KCNA2 and KCNA7 where the opposite is true (PubMed 20220134). {ECO 0000250|UniProtKB P63141, ECO 0000250|UniProtKB P63142, ECO 0000269|PubMed 19912772, ECO 0000269|PubMed 20220134}. 
# Ensembl	ENST00000316361	ENSP00000314520; ENSG00000177301. [P16389-1]
# Ensembl	ENST00000369770	ENSP00000358785; ENSG00000177301. [P16389-2]
# Ensembl	ENST00000485317	ENSP00000433109; ENSG00000177301. [P16389-1]
# Ensembl	ENST00000633222	ENSP00000487785; ENSG00000177301. [P16389-1]
# FUNCTION	KCNA2_HUMAN	Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium- selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed 19912772, PubMed 8495559, PubMed 11211111, PubMed 23769686). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed 8495559, PubMed 20220134). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA2 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed 19912772, PubMed 23769686). In contrast, a heteromultimer formed by KCNA2 and KCNA4 shows rapid inactivation (PubMed 8495559). Regulates neuronal excitability and plays a role as pacemaker in the regulation of neuronal action potentials (By similarity). KCNA2- containing channels play a presynaptic role and prevent hyperexcitability and aberrant action potential firing (By similarity). Response to toxins that are selective for KCNA2- containing potassium channels suggests that in Purkinje cells, dendritic subthreshold KCNA2-containing potassium channels prevent random spontaneous calcium spikes, suppressing dendritic hyperexcitability without hindering the generation of somatic action potentials, and thereby play an important role in motor coordination (By similarity). Plays a role in the induction of long-term potentiation of neuron excitability in the CA3 layer of the hippocampus (By similarity). May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons (By similarity). May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) (By similarity). Contributes to the regulation of the axonal release of the neurotransmitter dopamine (By similarity). Reduced KCNA2 expression plays a role in the perception of neuropathic pain after peripheral nerve injury, but not acute pain (By similarity). Plays a role in the regulation of the time spent in non-rapid eye movement (NREM) sleep (By similarity). {ECO 0000250|UniProtKB P63141, ECO 0000250|UniProtKB P63142, ECO 0000269|PubMed 11211111, ECO 0000269|PubMed 19912772, ECO 0000269|PubMed 20220134, ECO 0000269|PubMed 23769686, ECO 0000269|PubMed 8495559, ECO 0000305}. 
# GO_component	GO:0005789	endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IMP:UniProtKB.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IDA:UniProtKB.
# GO_component	GO:0030027	lamellipodium; ISS:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030424	axon; ISS:UniProtKB.
# GO_component	GO:0030425	dendrite; ISS:UniProtKB.
# GO_component	GO:0031258	lamellipodium membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0032809	neuronal cell body membrane; ISS:UniProtKB.
# GO_component	GO:0042734	presynaptic membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0043204	perikaryon; ISS:UniProtKB.
# GO_component	GO:0043679	axon terminus; ISS:UniProtKB.
# GO_component	GO:0044224	juxtaparanode region of axon; ISS:BHF-UCL.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IMP:UniProtKB.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; ISS:UniProtKB.
# GO_function	GO:0005267	potassium channel activity; TAS:ProtInc.
# GO_function	GO:0015271	outward rectifier potassium channel activity; IEA:Ensembl.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0014059	regulation of dopamine secretion; ISS:UniProtKB.
# GO_process	GO:0019228	neuronal action potential; ISS:UniProtKB.
# GO_process	GO:0019233	sensory perception of pain; ISS:UniProtKB.
# GO_process	GO:0021633	optic nerve structural organization; IEA:Ensembl.
# GO_process	GO:0045188	regulation of circadian sleep/wake cycle, non-REM sleep; IEA:Ensembl.
# GO_process	GO:0051260	protein homooligomerization; IEA:InterPro.
# GO_process	GO:0071805	potassium ion transmembrane transport; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.350	-; 1.
# Genevisible	P16389	HS
# HGNC	HGNC:6220	KCNA2
# INTERACTION	KCNA2_HUMAN	P49069 CAMLG; NbExp=3; IntAct=EBI-10210559, EBI-1748958; 
# InterPro	IPR000210	BTB/POZ_dom
# InterPro	IPR003131	T1-type_BTB
# InterPro	IPR003968	K_chnl_volt-dep_Kv
# InterPro	IPR003972	K_chnl_volt-dep_Kv1
# InterPro	IPR004049	K_chnl_volt-dep_Kv1.2
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR011333	SKP1/BTB/POZ
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko04040	Ion channels
# MIM	176262	gene
# MIM	616366	phenotype
# MISCELLANEOUS	The delay or D-type current observed in hippocampus pyramidal neurons is probably mediated by potassium channels containing KCNA2 plus KCNA1 or other family members. It is activated at about -50 mV, i.e. below the action potential threshold, and is characterized by slow inactivation, extremely slow recovery from inactivation, sensitivity to dendrotoxin (DTX) and to 4-aminopyridine (4-AP). {ECO:0000305|PubMed	17917103}. 
# Organism	KCNA2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11537	PTHR11537
# PIR	I77466	I77466
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01491	KVCHANNEL
# PRINTS	PR01496	SHAKERCHANEL
# PRINTS	PR01509	KV12CHANNEL
# PTM	KCNA2_HUMAN	N-glycosylated, with complex, sialylated N-glycans. {ECO 0000250|UniProtKB P63142}. 
# PTM	KCNA2_HUMAN	Phosphorylated on tyrosine residues; phosphorylation increases in response to ischemia (By similarity). Phosphorylated on tyrosine residues by activated PTK2B/PYK2 (By similarity). Phosphorylation on tyrosine residues suppresses ion channel activity (By similarity). Phosphorylated on tyrosine residues in response to CHRM1 activation; this abolishes interaction with CTTN. This is probably due to endocytosis of the phosphorylated channel subunits (By similarity). Phosphorylated on serine residues in response to increased cAMP levels; phosphorylation is apparently not catalyzed by PKA (By similarity). {ECO 0000250|UniProtKB P63142}. 
# Pfam	PF00520	Ion_trans
# Pfam	PF02214	BTB_2
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# RecName	KCNA2_HUMAN	Potassium voltage-gated channel subfamily A member 2
# RefSeq	NP_001191198	NM_001204269.1. [P16389-2]
# RefSeq	NP_004965	NM_004974.3. [P16389-1]
# RefSeq	XP_011539698	XM_011541396.2. [P16389-1]
# RefSeq	XP_011539699	XM_011541397.2. [P16389-1]
# RefSeq	XP_011539700	XM_011541398.2. [P16389-1]
# RefSeq	XP_011539701	XM_011541399.2. [P16389-1]
# RefSeq	XP_011539702	XM_011541400.2. [P16389-1]
# RefSeq	XP_016856702	XM_017001213.1. [P16389-1]
# SIMILARITY	Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily. {ECO	0000305}.
# SMART	SM00225	BTB
# SUBCELLULAR LOCATION	KCNA2_HUMAN	Cell membrane {ECO 0000269|PubMed 11211111, ECO 0000269|PubMed 19912772, ECO 0000269|PubMed 20220134, ECO 0000269|PubMed 23769686, ECO 0000269|PubMed 8495559}; Multi- pass membrane protein {ECO 0000250|UniProtKB P63142, ECO 0000305}. Membrane {ECO 0000250|UniProtKB P63142}. Cell projection, axon {ECO 0000269|PubMed 16473933}. Cell junction, synapse {ECO 0000250|UniProtKB P63142}. Endoplasmic reticulum membrane {ECO 0000250|UniProtKB P63142}. Cell projection, lamellipodium membrane {ECO 0000250|UniProtKB P63142}. Cell junction, synapse, synaptosome {ECO 0000250|UniProtKB P63141}. Cell junction, synapse, presynaptic cell membrane {ECO 0000250|UniProtKB P63141}. Cell projection, dendrite {ECO 0000250|UniProtKB P63141}. Note=KCNA2 by itself is detected both at the endoplasmic reticulum and at the cell membrane. Coexpression with KCNA4 or with beta subunits promotes expression at the cell membrane. Coexpression with KCNA1 inhibits cell surface expression. {ECO 0000250|UniProtKB P63142}. 
# SUBUNIT	KCNA2_HUMAN	Homotetramer and heterotetramer with other channel- forming alpha subunits, such as KCNA1, KCNA4, KCNA5, KCNA6 and KCNA7. Channel activity is regulated by interaction with the beta subunits, including KCNAB1 and KCNAB2. Identified in a complex with KCNA1 and KCNAB2 (PubMed 11086297). Identified in a complex with KCNA5 and KCNAB1 (By similarity). Identified in a complex with KCNA4 and FYN (By similarity). Interacts with the beta subunit KCNAB1 (PubMed 19713757). Interacts with PTK2B (By similarity). Interacts (via C-terminus) with CTTN (By similarity). Interacts (via N-terminal cytoplasmic domain) with RHOA (GTP-bound form); this regulates channel activity by reducing location at the cell surface in response to CHRM1 activation (By similarity). Interacts with DRD2 (By similarity). Interacts with SIGMAR1; cocaine consumption leads to increased interaction (By similarity). Interacts with ADAM22 (By similarity). Interacts (via C-terminus) with the PDZ domains of DLG1, DLG2 and DLG4 (By similarity). Interacts with CNTNAP2 (PubMed 10624965). {ECO 0000250|UniProtKB P63141, ECO 0000250|UniProtKB P63142, ECO 0000250|UniProtKB Q09081, ECO 0000269|PubMed 10624965, ECO 0000269|PubMed 11086297, ECO 0000269|PubMed 19713757, ECO 0000269|PubMed 8495559, ECO 0000305}. 
# SUPFAM	SSF54695	SSF54695
# TCDB	1.A.1.2.10	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	KCNA2_HUMAN	Detected in brain cortex (PubMed 16473933). Detected in peroneal nerve in the juxtaparanodal regions of the node of Ranvier; expression is decreased in patients with diabetes mellitus that suffer from axonal neuropathy (PubMed 22649228). Detected in paranodal and juxtanodal zones in myelinated spinal cord (at protein level) (PubMed 11086297). {ECO 0000269|PubMed 11086297, ECO 0000269|PubMed 16473933, ECO 0000269|PubMed 22649228}. 
# UCSC	uc009wfv	human. [P16389-1]
# eggNOG	COG1226	LUCA
# eggNOG	KOG1545	Eukaryota
BLAST	swissprot:KCNA2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNA2_HUMAN
BioCyc	ZFISH:ENSG00000177301-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000177301-MONOMER
COXPRESdb	3737	http://coxpresdb.jp/data/gene/3737.shtml
CleanEx	HS_KCNA2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNA2
DOI	10.1002/1096-9861(20000101)429:1<166::AID-CNE13>3.0.CO	http://dx.doi.org/10.1002/1096-9861(20000101)429:1<166::AID-CNE13>3.0.CO
DOI	10.1007/s004240000406	http://dx.doi.org/10.1007/s004240000406
DOI	10.1007/s12035-007-8001-0	http://dx.doi.org/10.1007/s12035-007-8001-0
DOI	10.1016/1044-7431(90)90004-N	http://dx.doi.org/10.1016/1044-7431(90)90004-N
DOI	10.1016/S0896-6273(00)81049-1	http://dx.doi.org/10.1016/S0896-6273(00)81049-1
DOI	10.1016/j.neulet.2013.05.048	http://dx.doi.org/10.1016/j.neulet.2013.05.048
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng.3239	http://dx.doi.org/10.1038/ng.3239
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0511197103	http://dx.doi.org/10.1073/pnas.0511197103
DOI	10.1074/jbc.M109.068486	http://dx.doi.org/10.1074/jbc.M109.068486
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/cge.12542	http://dx.doi.org/10.1111/cge.12542
DOI	10.1161/01.RES.72.6.1326	http://dx.doi.org/10.1161/01.RES.72.6.1326
DOI	10.1523/JNEUROSCI.0719-12.2012	http://dx.doi.org/10.1523/JNEUROSCI.0719-12.2012
DOI	10.4161/chan.3.5.9558	http://dx.doi.org/10.4161/chan.3.5.9558
DrugBank	DB06637	http://www.drugbank.ca/drugs/DB06637
EMBL	AK290061	http://www.ebi.ac.uk/ena/data/view/AK290061
EMBL	AL365361	http://www.ebi.ac.uk/ena/data/view/AL365361
EMBL	BC043564	http://www.ebi.ac.uk/ena/data/view/BC043564
EMBL	CH471122	http://www.ebi.ac.uk/ena/data/view/CH471122
EMBL	CH471122	http://www.ebi.ac.uk/ena/data/view/CH471122
EMBL	L02752	http://www.ebi.ac.uk/ena/data/view/L02752
Ensembl	ENST00000316361	http://www.ensembl.org/id/ENST00000316361
Ensembl	ENST00000369770	http://www.ensembl.org/id/ENST00000369770
Ensembl	ENST00000485317	http://www.ensembl.org/id/ENST00000485317
Ensembl	ENST00000633222	http://www.ensembl.org/id/ENST00000633222
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0030027	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030027
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030424	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030424
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0031258	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031258
GO_component	GO:0032809	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032809
GO_component	GO:0042734	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042734
GO_component	GO:0043204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043204
GO_component	GO:0043679	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043679
GO_component	GO:0044224	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044224
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_function	GO:0015271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015271
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0014059	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014059
GO_process	GO:0019228	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019228
GO_process	GO:0019233	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019233
GO_process	GO:0021633	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021633
GO_process	GO:0045188	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045188
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	KCNA2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNA2
GeneID	3737	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3737
GeneTree	ENSGT00760000118846	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118846
HGNC	HGNC:6220	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6220
HOGENOM	HOG000231015	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231015&db=HOGENOM6
HOVERGEN	HBG052230	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052230&db=HOVERGEN
HPA	CAB001976	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB001976
InParanoid	P16389	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16389
IntAct	P16389	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16389*
InterPro	IPR000210	http://www.ebi.ac.uk/interpro/entry/IPR000210
InterPro	IPR003131	http://www.ebi.ac.uk/interpro/entry/IPR003131
InterPro	IPR003968	http://www.ebi.ac.uk/interpro/entry/IPR003968
InterPro	IPR003972	http://www.ebi.ac.uk/interpro/entry/IPR003972
InterPro	IPR004049	http://www.ebi.ac.uk/interpro/entry/IPR004049
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR011333	http://www.ebi.ac.uk/interpro/entry/IPR011333
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	3737	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3737
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3737	http://www.genome.jp/dbget-bin/www_bget?hsa:3737
KEGG_Orthology	KO:K04875	http://www.genome.jp/dbget-bin/www_bget?KO:K04875
MIM	176262	http://www.ncbi.nlm.nih.gov/omim/176262
MIM	616366	http://www.ncbi.nlm.nih.gov/omim/616366
OMA	MTFHTYS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MTFHTYS
OrthoDB	EOG091G10NU	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G10NU
PANTHER	PTHR11537	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01491	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01491
PRINTS	PR01496	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01496
PRINTS	PR01509	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01509
PSORT	swissprot:KCNA2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNA2_HUMAN
PSORT-B	swissprot:KCNA2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNA2_HUMAN
PSORT2	swissprot:KCNA2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNA2_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF02214	http://pfam.xfam.org/family/PF02214
PharmGKB	PA206	http://www.pharmgkb.org/do/serve?objId=PA206&objCls=Gene
Phobius	swissprot:KCNA2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNA2_HUMAN
PhylomeDB	P16389	http://phylomedb.org/?seqid=P16389
ProteinModelPortal	P16389	http://www.proteinmodelportal.org/query/uniprot/P16389
PubMed	10624965	http://www.ncbi.nlm.nih.gov/pubmed/10624965
PubMed	11086297	http://www.ncbi.nlm.nih.gov/pubmed/11086297
PubMed	11211111	http://www.ncbi.nlm.nih.gov/pubmed/11211111
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16473933	http://www.ncbi.nlm.nih.gov/pubmed/16473933
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17917103	http://www.ncbi.nlm.nih.gov/pubmed/17917103
PubMed	19713757	http://www.ncbi.nlm.nih.gov/pubmed/19713757
PubMed	19912772	http://www.ncbi.nlm.nih.gov/pubmed/19912772
PubMed	20220134	http://www.ncbi.nlm.nih.gov/pubmed/20220134
PubMed	22649228	http://www.ncbi.nlm.nih.gov/pubmed/22649228
PubMed	23769686	http://www.ncbi.nlm.nih.gov/pubmed/23769686
PubMed	25477152	http://www.ncbi.nlm.nih.gov/pubmed/25477152
PubMed	25751627	http://www.ncbi.nlm.nih.gov/pubmed/25751627
PubMed	8495559	http://www.ncbi.nlm.nih.gov/pubmed/8495559
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
RefSeq	NP_001191198	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001191198
RefSeq	NP_004965	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004965
RefSeq	XP_011539698	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011539698
RefSeq	XP_011539699	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011539699
RefSeq	XP_011539700	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011539700
RefSeq	XP_011539701	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011539701
RefSeq	XP_011539702	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011539702
RefSeq	XP_016856702	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016856702
SMART	SM00225	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225
SMR	P16389	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P16389
STRING	9606.ENSP00000314520	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000314520&targetmode=cogs
SUPFAM	SSF54695	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54695
TCDB	1.A.1.2.10	http://www.tcdb.org/search/result.php?tc=1.A.1.2.10
UCSC	uc009wfv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc009wfv&org=rat
UniGene	Hs.248139	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.248139
UniGene	Hs.657199	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.657199
UniGene	Hs.731191	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.731191
UniProtKB	KCNA2_HUMAN	http://www.uniprot.org/uniprot/KCNA2_HUMAN
UniProtKB-AC	P16389	http://www.uniprot.org/uniprot/P16389
charge	swissprot:KCNA2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNA2_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG1545	http://eggnogapi.embl.de/nog_data/html/tree/KOG1545
epestfind	swissprot:KCNA2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNA2_HUMAN
garnier	swissprot:KCNA2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNA2_HUMAN
helixturnhelix	swissprot:KCNA2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNA2_HUMAN
hmoment	swissprot:KCNA2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNA2_HUMAN
iep	swissprot:KCNA2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNA2_HUMAN
inforesidue	swissprot:KCNA2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNA2_HUMAN
neXtProt	NX_P16389	http://www.nextprot.org/db/entry/NX_P16389
octanol	swissprot:KCNA2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNA2_HUMAN
pepcoil	swissprot:KCNA2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNA2_HUMAN
pepdigest	swissprot:KCNA2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNA2_HUMAN
pepinfo	swissprot:KCNA2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNA2_HUMAN
pepnet	swissprot:KCNA2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNA2_HUMAN
pepstats	swissprot:KCNA2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNA2_HUMAN
pepwheel	swissprot:KCNA2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNA2_HUMAN
pepwindow	swissprot:KCNA2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNA2_HUMAN
sigcleave	swissprot:KCNA2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNA2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	PANX1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96RD7-1; Sequence=Displayed; Name=2; IsoId=Q96RD7-2; Sequence=VSP_011476; 
# BioGrid	117295	12
# CCDS	CCDS8296	-. [Q96RD7-1]
# ChiTaRS	PANX1	human
# DrugBank	DB01032	Probenecid
# Ensembl	ENST00000227638	ENSP00000227638; ENSG00000110218. [Q96RD7-1]
# Ensembl	ENST00000436171	ENSP00000411461; ENSG00000110218. [Q96RD7-2]
# ExpressionAtlas	Q96RD7	baseline and differential
# FUNCTION	PANX1_HUMAN	Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis. {ECO 0000269|PubMed 16908669, ECO 0000269|PubMed 20829356}. 
# GO_component	GO:0005783	endoplasmic reticulum; IDA:UniProtKB.
# GO_component	GO:0005789	endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0005921	gap junction; IEA:UniProtKB-SubCell.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0032059	bleb; IDA:BHF-UCL.
# GO_component	GO:0043234	protein complex; IEA:Ensembl.
# GO_function	GO:0005102	receptor binding; IPI:UniProtKB.
# GO_function	GO:0005262	calcium channel activity; IMP:UniProtKB.
# GO_function	GO:0022840	leak channel activity; IMP:UniProtKB.
# GO_function	GO:0055077	gap junction hemi-channel activity; IDA:UniProtKB.
# GO_process	GO:0002931	response to ischemia; IEA:Ensembl.
# GO_process	GO:0006812	cation transport; IDA:BHF-UCL.
# GO_process	GO:0006816	calcium ion transport; IMP:UniProtKB.
# GO_process	GO:0007267	cell-cell signaling; IBA:GO_Central.
# GO_process	GO:0033198	response to ATP; IEA:Ensembl.
# GO_process	GO:0034214	protein hexamerization; IDA:UniProtKB.
# GO_process	GO:0050717	positive regulation of interleukin-1 alpha secretion; IEA:Ensembl.
# GO_process	GO:0050718	positive regulation of interleukin-1 beta secretion; IDA:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q96RD7	HS
# HGNC	HGNC:8599	PANX1
# IntAct	Q96RD7	7
# InterPro	IPR000990	Innexin
# KEGG_Brite	ko02000	Transporters
# MIM	608420	gene
# Organism	PANX1_HUMAN	Homo sapiens (Human)
# PROSITE	PS51013	PANNEXIN
# PTM	PANX1_HUMAN	S-nitrosylation inhibits channel currents and ATP release. {ECO 0000250}. 
# Pfam	PF00876	Innexin
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-112303	Electric Transmission Across Gap Junctions
# Reactome	R-HSA-844456	The NLRP3 inflammasome
# RecName	PANX1_HUMAN	Pannexin-1
# RefSeq	NP_056183	NM_015368.3. [Q96RD7-1]
# SIMILARITY	Belongs to the pannexin family. {ECO:0000255|PROSITE- ProRule	PRU00351}. 
# SUBCELLULAR LOCATION	PANX1_HUMAN	Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00351}. Cell junction, gap junction {ECO 0000269|PubMed 16908669, ECO 0000269|PubMed 17715132}. Endoplasmic reticulum membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000255|PROSITE- ProRule PRU00351}. 
# SUBUNIT	Homohexamer. Forms homomeric or PANX1/PANX2-heteromeric intercellular channels on coexpression in paired Xenopus oocytes (By similarity). {ECO	0000250}. 
# TCDB	1.A.25.2	the gap junction-forming innexin (innexin) family
# UCSC	uc001peq	human. [Q96RD7-1]
# WEB RESOURCE	PANX1_HUMAN	Name=Wikipedia; Note=Pannexin entry; URL="https //en.wikipedia.org/wiki/Pannexin";
# eggNOG	ENOG410II5X	Eukaryota
# eggNOG	ENOG410YA5H	LUCA
BLAST	swissprot:PANX1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:PANX1_HUMAN
BioCyc	ZFISH:ENSG00000110218-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000110218-MONOMER
COXPRESdb	24145	http://coxpresdb.jp/data/gene/24145.shtml
CleanEx	HS_PANX1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_PANX1
DIP	DIP-43936N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-43936N
DOI	10.1016/j.ygeno.2003.09.025	http://dx.doi.org/10.1016/j.ygeno.2003.09.025
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1074/jbc.M110.101014	http://dx.doi.org/10.1074/jbc.M110.101014
DOI	10.1074/jbc.M702422200	http://dx.doi.org/10.1074/jbc.M702422200
DOI	10.1083/jcb.200601115	http://dx.doi.org/10.1083/jcb.200601115
DOI	10.1093/dnares/12.2.117	http://dx.doi.org/10.1093/dnares/12.2.117
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB01032	http://www.drugbank.ca/drugs/DB01032
EMBL	AF093239	http://www.ebi.ac.uk/ena/data/view/AF093239
EMBL	AF398506	http://www.ebi.ac.uk/ena/data/view/AF398506
EMBL	AF398507	http://www.ebi.ac.uk/ena/data/view/AF398507
EMBL	AF398508	http://www.ebi.ac.uk/ena/data/view/AF398508
EMBL	AF398509	http://www.ebi.ac.uk/ena/data/view/AF398509
EMBL	AH010945	http://www.ebi.ac.uk/ena/data/view/AH010945
EMBL	AK074897	http://www.ebi.ac.uk/ena/data/view/AK074897
EMBL	AP003966	http://www.ebi.ac.uk/ena/data/view/AP003966
EMBL	AY048509	http://www.ebi.ac.uk/ena/data/view/AY048509
EMBL	AY359023	http://www.ebi.ac.uk/ena/data/view/AY359023
EMBL	BC016931	http://www.ebi.ac.uk/ena/data/view/BC016931
Ensembl	ENST00000227638	http://www.ensembl.org/id/ENST00000227638
Ensembl	ENST00000436171	http://www.ensembl.org/id/ENST00000436171
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005921	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005921
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0032059	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032059
GO_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GO_function	GO:0005102	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005102
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0022840	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022840
GO_function	GO:0055077	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055077
GO_process	GO:0002931	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002931
GO_process	GO:0006812	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006812
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GO_process	GO:0033198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033198
GO_process	GO:0034214	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034214
GO_process	GO:0050717	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050717
GO_process	GO:0050718	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050718
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	PANX1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=PANX1
GeneID	24145	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24145
GeneTree	ENSGT00390000009703	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000009703
H-InvDB	HIX0010028	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0010028
HGNC	HGNC:8599	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:8599
HOVERGEN	HBG053497	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053497&db=HOVERGEN
HPA	HPA016930	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA016930
InParanoid	Q96RD7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96RD7
IntAct	Q96RD7	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96RD7*
InterPro	IPR000990	http://www.ebi.ac.uk/interpro/entry/IPR000990
Jabion	24145	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=24145
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:24145	http://www.genome.jp/dbget-bin/www_bget?hsa:24145
KEGG_Orthology	KO:K03443	http://www.genome.jp/dbget-bin/www_bget?KO:K03443
MIM	608420	http://www.ncbi.nlm.nih.gov/omim/608420
MINT	MINT-3379479	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3379479
OMA	VPFRQKT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VPFRQKT
OrthoDB	EOG091G086D	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G086D
PROSITE	PS51013	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51013
PSORT	swissprot:PANX1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:PANX1_HUMAN
PSORT-B	swissprot:PANX1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:PANX1_HUMAN
PSORT2	swissprot:PANX1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:PANX1_HUMAN
Pfam	PF00876	http://pfam.xfam.org/family/PF00876
PharmGKB	PA32929	http://www.pharmgkb.org/do/serve?objId=PA32929&objCls=Gene
Phobius	swissprot:PANX1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:PANX1_HUMAN
PhylomeDB	Q96RD7	http://phylomedb.org/?seqid=Q96RD7
ProteinModelPortal	Q96RD7	http://www.proteinmodelportal.org/query/uniprot/Q96RD7
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	15028292	http://www.ncbi.nlm.nih.gov/pubmed/15028292
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16303743	http://www.ncbi.nlm.nih.gov/pubmed/16303743
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	16908669	http://www.ncbi.nlm.nih.gov/pubmed/16908669
PubMed	17715132	http://www.ncbi.nlm.nih.gov/pubmed/17715132
PubMed	20829356	http://www.ncbi.nlm.nih.gov/pubmed/20829356
Reactome	R-HSA-112303	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112303
Reactome	R-HSA-844456	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-844456
RefSeq	NP_056183	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_056183
STRING	9606.ENSP00000227638	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000227638&targetmode=cogs
TCDB	1.A.25.2	http://www.tcdb.org/search/result.php?tc=1.A.25.2
UCSC	uc001peq	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001peq&org=rat
UniGene	Hs.591976	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.591976
UniProtKB	PANX1_HUMAN	http://www.uniprot.org/uniprot/PANX1_HUMAN
UniProtKB-AC	Q96RD7	http://www.uniprot.org/uniprot/Q96RD7
charge	swissprot:PANX1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:PANX1_HUMAN
eggNOG	ENOG410II5X	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410II5X
eggNOG	ENOG410YA5H	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YA5H
epestfind	swissprot:PANX1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:PANX1_HUMAN
garnier	swissprot:PANX1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:PANX1_HUMAN
helixturnhelix	swissprot:PANX1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:PANX1_HUMAN
hmoment	swissprot:PANX1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:PANX1_HUMAN
iep	swissprot:PANX1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:PANX1_HUMAN
inforesidue	swissprot:PANX1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:PANX1_HUMAN
neXtProt	NX_Q96RD7	http://www.nextprot.org/db/entry/NX_Q96RD7
octanol	swissprot:PANX1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:PANX1_HUMAN
pepcoil	swissprot:PANX1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:PANX1_HUMAN
pepdigest	swissprot:PANX1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:PANX1_HUMAN
pepinfo	swissprot:PANX1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:PANX1_HUMAN
pepnet	swissprot:PANX1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:PANX1_HUMAN
pepstats	swissprot:PANX1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:PANX1_HUMAN
pepwheel	swissprot:PANX1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:PANX1_HUMAN
pepwindow	swissprot:PANX1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:PANX1_HUMAN
sigcleave	swissprot:PANX1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:PANX1_HUMAN
## Database	ID	URL or Descriptions
# AltName	S26A2_HUMAN	Diastrophic dysplasia protein
# AltName	S26A2_HUMAN	Solute carrier family 26 member 2
# BioGrid	108169	13
# ChiTaRS	SLC26A2	human
# DISEASE	S26A2_HUMAN	Achondrogenesis 1B (ACG1B) [MIM 600972]  A form of achondrogenesis type 1, a lethal form of chondrodysplasia characterized by deficient ossification in the lumbar vertebrae and absent ossification in the sacral, pubic and ischial bones and clinically by stillbirth or early death. In addition to severe micromelia, there is a disproportionately large cranium due to marked edema of soft tissues. {ECO 0000269|PubMed 8528239}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	S26A2_HUMAN	Atelosteogenesis 2 (AO2) [MIM 256050]  A perinatal dysplasia characterized by shortening of the limbs, a dysmorphic syndrome and radiographic skeletal features. Patients are stillborn or die soon after birth. {ECO 0000269|PubMed 8571951}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	S26A2_HUMAN	Diastrophic dysplasia (DTD) [MIM 222600]  An autosomal recessive disease characterized by osteochondrodysplasia with clinical features including dwarfism, spinal deformation, and specific joint abnormalities. {ECO 0000269|PubMed 10466420}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	S26A2_HUMAN	Multiple epiphyseal dysplasia 4 (EDM4) [MIM 226900]  A generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. Radiological examination of the skeleton shows delayed, irregular mineralization of the epiphyseal ossification centers and of the centers of the carpal and tarsal bones. Multiple epiphyseal dysplasia is broadly categorized into the more severe Fairbank and the milder Ribbing types. The Fairbank type is characterized by shortness of stature, short and stubby fingers, small epiphyses in several joints, including the knee, ankle, hand, and hip. The Ribbing type is confined predominantly to the hip joints and is characterized by hands that are normal and stature that is normal or near-normal. Multiple epiphyseal dysplasia type 4 is a recessively inherited form, characterized by early childhood-onset hip dysplasia and recurrent patella dislocation. Short stature is not frequent. {ECO 0000269|PubMed 12966518, ECO 0000269|PubMed 21922596}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000286298	ENSP00000286298; ENSG00000155850
# ExpressionAtlas	P50443	baseline and differential
# FUNCTION	S26A2_HUMAN	Sulfate transporter. May play a role in endochondral bone formation. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005254	chloride channel activity; IBA:GO_Central.
# GO_function	GO:0008271	secondary active sulfate transmembrane transporter activity; IEA:InterPro.
# GO_function	GO:0015106	bicarbonate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015116	sulfate transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0019531	oxalate transmembrane transporter activity; IBA:GO_Central.
# GO_function	S26A2_HUMAN	GO 0015301 anion anion antiporter activity; IBA GO_Central.
# GO_process	GO:0001503	ossification; IEA:Ensembl.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0008272	sulfate transport; TAS:ProtInc.
# GO_process	GO:0015701	bicarbonate transport; IBA:GO_Central.
# GO_process	GO:0042391	regulation of membrane potential; IBA:GO_Central.
# GO_process	GO:0050428	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process; TAS:Reactome.
# GO_process	GO:0051453	regulation of intracellular pH; IBA:GO_Central.
# GO_process	GO:1902476	chloride transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006790	sulfur compound metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.30.750.24	-; 2.
# Genevisible	P50443	HS
# HGNC	HGNC:10994	SLC26A2
# InterPro	IPR001902	SLC26A/SulP_fam
# InterPro	IPR002645	STAS_dom
# InterPro	IPR011547	SLC26A/SulP_dom
# InterPro	IPR018045	S04_transporter_CS
# InterPro	IPR030280	SLC26A2
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H00476	[Skeletal dysplasia] Multiple epiphyseal dysplasia (MED)
# KEGG_Disease	H00515	[Skeletal dysplasia] Diastrophic dysplasia (DTD)
# MIM	222600	phenotype
# MIM	226900	phenotype
# MIM	256050	phenotype
# MIM	600972	phenotype
# MIM	606718	gene
# Organism	S26A2_HUMAN	Homo sapiens (Human)
# Orphanet	56304	Atelosteogenesis type II
# Orphanet	628	Diastrophic dwarfism
# Orphanet	93298	Achondrogenesis type 1B
# Orphanet	93307	Multiple epiphyseal dysplasia type 4
# PANTHER	PTHR11814	PTHR11814; 3
# PANTHER	PTHR11814:SF16	PTHR11814:SF16; 3
# PIR	A54808	A54808
# PROSITE	PS01130	SLC26A
# PROSITE	PS50801	STAS
# Pfam	PF00916	Sulfate_transp
# Pfam	PF01740	STAS
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-174362	Transport and synthesis of PAPS
# Reactome	R-HSA-427601	Multifunctional anion exchangers
# RecName	S26A2_HUMAN	Sulfate transporter
# RefSeq	NP_000103	NM_000112.3
# RefSeq	XP_016864680	XM_017009191.1
# SIMILARITY	Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. {ECO	0000305}. 
# SIMILARITY	Contains 1 STAS domain. {ECO:0000255|PROSITE- ProRule	PRU00198}.
# SUBCELLULAR LOCATION	S26A2_HUMAN	Membrane; Multi-pass membrane protein. 
# SUPFAM	SSF52091	SSF52091; 2
# TCDB	2.A.53.2	the sulfate permease (sulp) family
# TIGRFAMs	TIGR00815	sulP
# TISSUE SPECIFICITY	S26A2_HUMAN	Ubiquitously expressed. 
# UCSC	uc003lrh	human
# eggNOG	COG0659	LUCA
# eggNOG	KOG0236	Eukaryota
BLAST	swissprot:S26A2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S26A2_HUMAN
BioCyc	ZFISH:ENSG00000155850-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000155850-MONOMER
COXPRESdb	1836	http://coxpresdb.jp/data/gene/1836.shtml
CleanEx	HS_SLC26A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC26A2
DOI	10.1002/ajmg.a.20282	http://dx.doi.org/10.1002/ajmg.a.20282
DOI	10.1002/humu.21611	http://dx.doi.org/10.1002/humu.21611
DOI	10.1016/0092-8674(94)90281-X	http://dx.doi.org/10.1016/0092-8674(94)90281-X
DOI	10.1034/j.1399-0004.1999.560110.x	http://dx.doi.org/10.1034/j.1399-0004.1999.560110.x
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1038/ng0196-100	http://dx.doi.org/10.1038/ng0196-100
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AC008427	http://www.ebi.ac.uk/ena/data/view/AC008427
EMBL	AK290358	http://www.ebi.ac.uk/ena/data/view/AK290358
EMBL	AK312596	http://www.ebi.ac.uk/ena/data/view/AK312596
EMBL	BC059390	http://www.ebi.ac.uk/ena/data/view/BC059390
EMBL	BX640696	http://www.ebi.ac.uk/ena/data/view/BX640696
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	U14528	http://www.ebi.ac.uk/ena/data/view/U14528
Ensembl	ENST00000286298	http://www.ensembl.org/id/ENST00000286298
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0008271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008271
GO_function	GO:0015106	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015106
GO_function	GO:0015116	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015116
GO_function	GO:0015301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015301
GO_function	GO:0019531	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019531
GO_process	GO:0001503	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001503
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0008272	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008272
GO_process	GO:0015701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015701
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0050428	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050428
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.30.750.24	http://www.cathdb.info/version/latest/superfamily/3.30.750.24
GeneCards	SLC26A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC26A2
GeneID	1836	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1836
GeneTree	ENSGT00760000119026	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119026
H-InvDB	HIX0005307	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0005307
HGNC	HGNC:10994	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10994
HOGENOM	HOG000006546	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006546&db=HOGENOM6
HOVERGEN	HBG000639	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000639&db=HOVERGEN
HPA	HPA041957	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA041957
HPA	HPA058090	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA058090
InParanoid	P50443	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P50443
IntAct	P50443	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P50443*
InterPro	IPR001902	http://www.ebi.ac.uk/interpro/entry/IPR001902
InterPro	IPR002645	http://www.ebi.ac.uk/interpro/entry/IPR002645
InterPro	IPR011547	http://www.ebi.ac.uk/interpro/entry/IPR011547
InterPro	IPR018045	http://www.ebi.ac.uk/interpro/entry/IPR018045
InterPro	IPR030280	http://www.ebi.ac.uk/interpro/entry/IPR030280
Jabion	1836	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1836
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00476	http://www.genome.jp/dbget-bin/www_bget?H00476
KEGG_Disease	H00515	http://www.genome.jp/dbget-bin/www_bget?H00515
KEGG_Gene	hsa:1836	http://www.genome.jp/dbget-bin/www_bget?hsa:1836
KEGG_Orthology	KO:K14701	http://www.genome.jp/dbget-bin/www_bget?KO:K14701
MIM	222600	http://www.ncbi.nlm.nih.gov/omim/222600
MIM	226900	http://www.ncbi.nlm.nih.gov/omim/226900
MIM	256050	http://www.ncbi.nlm.nih.gov/omim/256050
MIM	600972	http://www.ncbi.nlm.nih.gov/omim/600972
MIM	606718	http://www.ncbi.nlm.nih.gov/omim/606718
MINT	MINT-5001062	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5001062
OMA	YPRIHME	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YPRIHME
Orphanet	56304	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=56304
Orphanet	628	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=628
Orphanet	93298	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=93298
Orphanet	93307	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=93307
OrthoDB	EOG091G07RT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07RT
PANTHER	PTHR11814	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11814
PANTHER	PTHR11814:SF16	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11814:SF16
PROSITE	PS01130	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01130
PROSITE	PS50801	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50801
PSORT	swissprot:S26A2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S26A2_HUMAN
PSORT-B	swissprot:S26A2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S26A2_HUMAN
PSORT2	swissprot:S26A2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S26A2_HUMAN
Pfam	PF00916	http://pfam.xfam.org/family/PF00916
Pfam	PF01740	http://pfam.xfam.org/family/PF01740
PharmGKB	PA149	http://www.pharmgkb.org/do/serve?objId=PA149&objCls=Gene
Phobius	swissprot:S26A2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S26A2_HUMAN
PhylomeDB	P50443	http://phylomedb.org/?seqid=P50443
ProteinModelPortal	P50443	http://www.proteinmodelportal.org/query/uniprot/P50443
PubMed	10466420	http://www.ncbi.nlm.nih.gov/pubmed/10466420
PubMed	12966518	http://www.ncbi.nlm.nih.gov/pubmed/12966518
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	21922596	http://www.ncbi.nlm.nih.gov/pubmed/21922596
PubMed	7923357	http://www.ncbi.nlm.nih.gov/pubmed/7923357
PubMed	8528239	http://www.ncbi.nlm.nih.gov/pubmed/8528239
PubMed	8571951	http://www.ncbi.nlm.nih.gov/pubmed/8571951
Reactome	R-HSA-174362	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-174362
Reactome	R-HSA-427601	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-427601
RefSeq	NP_000103	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000103
RefSeq	XP_016864680	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016864680
STRING	9606.ENSP00000286298	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000286298&targetmode=cogs
SUPFAM	SSF52091	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52091
TCDB	2.A.53.2	http://www.tcdb.org/search/result.php?tc=2.A.53.2
TIGRFAMs	TIGR00815	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00815
UCSC	uc003lrh	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003lrh&org=rat
UniGene	Hs.302738	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.302738
UniProtKB	S26A2_HUMAN	http://www.uniprot.org/uniprot/S26A2_HUMAN
UniProtKB-AC	P50443	http://www.uniprot.org/uniprot/P50443
charge	swissprot:S26A2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S26A2_HUMAN
eggNOG	COG0659	http://eggnogapi.embl.de/nog_data/html/tree/COG0659
eggNOG	KOG0236	http://eggnogapi.embl.de/nog_data/html/tree/KOG0236
epestfind	swissprot:S26A2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S26A2_HUMAN
garnier	swissprot:S26A2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S26A2_HUMAN
helixturnhelix	swissprot:S26A2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S26A2_HUMAN
hmoment	swissprot:S26A2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S26A2_HUMAN
iep	swissprot:S26A2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S26A2_HUMAN
inforesidue	swissprot:S26A2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S26A2_HUMAN
neXtProt	NX_P50443	http://www.nextprot.org/db/entry/NX_P50443
octanol	swissprot:S26A2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S26A2_HUMAN
pepcoil	swissprot:S26A2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S26A2_HUMAN
pepdigest	swissprot:S26A2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S26A2_HUMAN
pepinfo	swissprot:S26A2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S26A2_HUMAN
pepnet	swissprot:S26A2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S26A2_HUMAN
pepstats	swissprot:S26A2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S26A2_HUMAN
pepwheel	swissprot:S26A2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S26A2_HUMAN
pepwindow	swissprot:S26A2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S26A2_HUMAN
sigcleave	swissprot:S26A2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S26A2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ACHB_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P11230-1; Sequence=Displayed; Name=2; IsoId=P11230-2; Sequence=VSP_056675; Note=No experimental confirmation available.; 
# CCDS	CCDS11106	-. [P11230-1]
# ChiTaRS	CHRNB1	human
# DISEASE	ACHB_HUMAN	Myasthenic syndrome, congenital, 2A, slow-channel (CMS2A) [MIM 616313]  A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. CMS2A is a slow-channel myasthenic syndrome. It is caused by kinetic abnormalities of the AChR, resulting in prolonged AChR channel opening episodes, prolonged endplate currents, and depolarization block. This is associated with calcium overload, which may contribute to subsequent degeneration of the endplate and postsynaptic membrane. {ECO 0000269|PubMed 8651643, ECO 0000269|PubMed 8872460}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ACHB_HUMAN	Myasthenic syndrome, congenital, 2C, associated with acetylcholine receptor deficiency (CMS2C) [MIM 616314]  A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. CMS2C is an autosomal recessive disorder of postsynaptic neuromuscular transmission, due to deficiency of AChR at the endplate that results in low amplitude of the miniature endplate potential and current. CMS2C is clinically characterized by early-onset muscle weakness with variable severity. {ECO 0000269|PubMed 10562302}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00674	Galantamine
# Ensembl	ENST00000306071	ENSP00000304290; ENSG00000170175. [P11230-1]
# Ensembl	ENST00000536404	ENSP00000439209; ENSG00000170175. [P11230-2]
# ExpressionAtlas	P11230	baseline and differential
# FUNCTION	ACHB_HUMAN	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. 
# GO_component	GO:0005887	integral component of plasma membrane; NAS:UniProtKB.
# GO_component	GO:0005892	acetylcholine-gated channel complex; IMP:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0045202	synapse; IMP:UniProtKB.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0004889	acetylcholine-activated cation-selective channel activity; IEA:Ensembl.
# GO_function	GO:0015267	channel activity; IMP:UniProtKB.
# GO_function	GO:0015276	ligand-gated ion channel activity; ISS:UniProtKB.
# GO_function	GO:0042166	acetylcholine binding; ISS:UniProtKB.
# GO_process	GO:0001941	postsynaptic membrane organization; IMP:UniProtKB.
# GO_process	GO:0003009	skeletal muscle contraction; IEA:Ensembl.
# GO_process	GO:0006812	cation transport; IMP:UniProtKB.
# GO_process	GO:0006936	muscle contraction; IMP:UniProtKB.
# GO_process	GO:0007165	signal transduction; IMP:UniProtKB.
# GO_process	GO:0007271	synaptic transmission, cholinergic; IMP:UniProtKB.
# GO_process	GO:0007274	neuromuscular synaptic transmission; IMP:UniProtKB.
# GO_process	GO:0035095	behavioral response to nicotine; IMP:UniProtKB.
# GO_process	GO:0042391	regulation of membrane potential; ISS:UniProtKB.
# GO_process	GO:0048747	muscle fiber development; IMP:UniProtKB.
# GO_process	GO:0050877	neurological system process; IMP:UniProtKB.
# GO_process	GO:0098655	cation transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# GOslim_process	GO:0061024	membrane organization
# Gene3D	1.20.120.370	-; 2.
# Gene3D	2.70.170.10	-; 1.
# Genevisible	P11230	HS
# HGNC	HGNC:1961	CHRNB1
# InterPro	IPR002394	Nicotinic_acetylcholine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# InterPro	IPR027361	Acetylcholine_rcpt_TM
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00770	[Nervous system disease] Congenital myasthenic syndrome
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# MIM	100710	gene
# MIM	616313	phenotype
# MIM	616314	phenotype
# Organism	ACHB_HUMAN	Homo sapiens (Human)
# Orphanet	98913	Postsynaptic congenital myasthenic syndromes
# PANTHER	PTHR18945	PTHR18945; 2
# PIR	S04607	S04607
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00254	NICOTINICR
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 17
# RecName	ACHB_HUMAN	Acetylcholine receptor subunit beta
# RefSeq	NP_000738	NM_000747.2. [P11230-1]
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta- 1/CHRNB1 sub-subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	ACHB_HUMAN	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	ACHB_HUMAN	Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TCDB	1.A.9.1	the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family
# TIGRFAMs	TIGR00860	LIC
# UCSC	uc002ghb	human. [P11230-1]
# eggNOG	ENOG410XQGR	LUCA
# eggNOG	KOG3645	Eukaryota
BLAST	swissprot:ACHB_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ACHB_HUMAN
BioCyc	ZFISH:ENSG00000170175-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000170175-MONOMER
COXPRESdb	1140	http://coxpresdb.jp/data/gene/1140.shtml
CleanEx	HS_CHRNB1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CHRNB1
DOI	10.1002/ana.410390607	http://dx.doi.org/10.1002/ana.410390607
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/hmg/5.9.1217	http://dx.doi.org/10.1093/hmg/5.9.1217
DOI	10.1093/nar/17.11.4391	http://dx.doi.org/10.1093/nar/17.11.4391
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1172/JCI8179	http://dx.doi.org/10.1172/JCI8179
DrugBank	DB00674	http://www.drugbank.ca/drugs/DB00674
EMBL	AC113189	http://www.ebi.ac.uk/ena/data/view/AC113189
EMBL	AK298938	http://www.ebi.ac.uk/ena/data/view/AK298938
EMBL	BC011371	http://www.ebi.ac.uk/ena/data/view/BC011371
EMBL	BC023553	http://www.ebi.ac.uk/ena/data/view/BC023553
EMBL	X14830	http://www.ebi.ac.uk/ena/data/view/X14830
Ensembl	ENST00000306071	http://www.ensembl.org/id/ENST00000306071
Ensembl	ENST00000536404	http://www.ensembl.org/id/ENST00000536404
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005892	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005892
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0045202	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045202
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0004889	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004889
GO_function	GO:0015267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015267
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_function	GO:0042166	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042166
GO_process	GO:0001941	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001941
GO_process	GO:0003009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003009
GO_process	GO:0006812	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006812
GO_process	GO:0006936	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006936
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007271
GO_process	GO:0007274	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007274
GO_process	GO:0035095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035095
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0048747	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048747
GO_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GO_process	GO:0098655	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098655
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
Gene3D	1.20.120.370	http://www.cathdb.info/version/latest/superfamily/1.20.120.370
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	CHRNB1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CHRNB1
GeneID	1140	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1140
GeneTree	ENSGT00760000118930	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118930
HGNC	HGNC:1961	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1961
HOGENOM	HOG000006757	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006757&db=HOGENOM6
HOVERGEN	HBG003756	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003756&db=HOVERGEN
HPA	CAB011200	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB011200
HPA	HPA005822	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA005822
InParanoid	P11230	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P11230
IntAct	P11230	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P11230*
InterPro	IPR002394	http://www.ebi.ac.uk/interpro/entry/IPR002394
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
InterPro	IPR027361	http://www.ebi.ac.uk/interpro/entry/IPR027361
Jabion	1140	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1140
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00770	http://www.genome.jp/dbget-bin/www_bget?H00770
KEGG_Gene	hsa:1140	http://www.genome.jp/dbget-bin/www_bget?hsa:1140
KEGG_Orthology	KO:K04812	http://www.genome.jp/dbget-bin/www_bget?KO:K04812
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
MIM	100710	http://www.ncbi.nlm.nih.gov/omim/100710
MIM	616313	http://www.ncbi.nlm.nih.gov/omim/616313
MIM	616314	http://www.ncbi.nlm.nih.gov/omim/616314
MINT	MINT-3007602	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3007602
OMA	FIDGPNR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FIDGPNR
Orphanet	98913	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98913
OrthoDB	EOG091G0R20	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0R20
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00254	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00254
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:ACHB_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ACHB_HUMAN
PSORT-B	swissprot:ACHB_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ACHB_HUMAN
PSORT2	swissprot:ACHB_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ACHB_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA26494	http://www.pharmgkb.org/do/serve?objId=PA26494&objCls=Gene
Phobius	swissprot:ACHB_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ACHB_HUMAN
PhylomeDB	P11230	http://phylomedb.org/?seqid=P11230
ProteinModelPortal	P11230	http://www.proteinmodelportal.org/query/uniprot/P11230
PubMed	10562302	http://www.ncbi.nlm.nih.gov/pubmed/10562302
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	2740233	http://www.ncbi.nlm.nih.gov/pubmed/2740233
PubMed	8651643	http://www.ncbi.nlm.nih.gov/pubmed/8651643
PubMed	8872460	http://www.ncbi.nlm.nih.gov/pubmed/8872460
RefSeq	NP_000738	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000738
STRING	9606.ENSP00000304290	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000304290&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TCDB	1.A.9.1	http://www.tcdb.org/search/result.php?tc=1.A.9.1
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc002ghb	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ghb&org=rat
UniGene	Hs.330386	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.330386
UniProtKB	ACHB_HUMAN	http://www.uniprot.org/uniprot/ACHB_HUMAN
UniProtKB-AC	P11230	http://www.uniprot.org/uniprot/P11230
charge	swissprot:ACHB_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ACHB_HUMAN
eggNOG	ENOG410XQGR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQGR
eggNOG	KOG3645	http://eggnogapi.embl.de/nog_data/html/tree/KOG3645
epestfind	swissprot:ACHB_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ACHB_HUMAN
garnier	swissprot:ACHB_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ACHB_HUMAN
helixturnhelix	swissprot:ACHB_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACHB_HUMAN
hmoment	swissprot:ACHB_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ACHB_HUMAN
iep	swissprot:ACHB_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ACHB_HUMAN
inforesidue	swissprot:ACHB_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ACHB_HUMAN
neXtProt	NX_P11230	http://www.nextprot.org/db/entry/NX_P11230
octanol	swissprot:ACHB_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ACHB_HUMAN
pepcoil	swissprot:ACHB_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ACHB_HUMAN
pepdigest	swissprot:ACHB_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ACHB_HUMAN
pepinfo	swissprot:ACHB_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ACHB_HUMAN
pepnet	swissprot:ACHB_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ACHB_HUMAN
pepstats	swissprot:ACHB_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ACHB_HUMAN
pepwheel	swissprot:ACHB_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ACHB_HUMAN
pepwindow	swissprot:ACHB_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ACHB_HUMAN
sigcleave	swissprot:ACHB_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ACHB_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SERC4_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A6NH21-1; Sequence=Displayed; Name=2; IsoId=A6NH21-2; Sequence=VSP_033584, VSP_033585; 
# CCDS	CCDS58360	-. [A6NH21-1]
# Ensembl	ENST00000319327	ENSP00000319796; ENSG00000184716. [A6NH21-1]
# ExpressionAtlas	A6NH21	baseline and differential
# FUNCTION	SERC4_HUMAN	Incorporates a polar amino acid serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids. {ECO 0000269|PubMed 16120614}. 
# GO_component	GO:0016021	integral component of membrane; IBA:GO_Central.
# GO_function	GO:0015194	L-serine transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0008654	phospholipid biosynthetic process; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0009058	biosynthetic process
# HGNC	HGNC:32237	SERINC4
# InterPro	IPR005016	TDE1/TMS
# InterPro	IPR029563	Serinc4
# MIM	614550	gene
# Organism	SERC4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10383	PTHR10383
# PANTHER	PTHR10383:SF5	PTHR10383:SF5
# Pfam	PF03348	Serinc
# Proteomes	UP000005640	Chromosome 15
# Reactome	R-HSA-977347	Serine biosynthesis
# RecName	SERC4_HUMAN	Serine incorporator 4
# RefSeq	NP_001244960	NM_001258031.1. [A6NH21-1]
# RefSeq	NP_001244961	NM_001258032.1. [A6NH21-2]
# SIMILARITY	Belongs to the TDE1 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	SERC4_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# UCSC	uc031qrp	human. [A6NH21-1]
# eggNOG	ENOG410XP7K	LUCA
# eggNOG	KOG2592	Eukaryota
BLAST	swissprot:SERC4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SERC4_HUMAN
BioCyc	ZFISH:G66-30839-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-30839-MONOMER
COXPRESdb	619189	http://coxpresdb.jp/data/gene/619189.shtml
CleanEx	HS_SERINC4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SERINC4
DOI	10.1038/nature04601	http://dx.doi.org/10.1038/nature04601
DOI	10.1074/jbc.M505712200	http://dx.doi.org/10.1074/jbc.M505712200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC018512	http://www.ebi.ac.uk/ena/data/view/AC018512
EMBL	BC136669	http://www.ebi.ac.uk/ena/data/view/BC136669
EMBL	CH471082	http://www.ebi.ac.uk/ena/data/view/CH471082
EMBL	CH471082	http://www.ebi.ac.uk/ena/data/view/CH471082
EMBL	DQ103711	http://www.ebi.ac.uk/ena/data/view/DQ103711
Ensembl	ENST00000319327	http://www.ensembl.org/id/ENST00000319327
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015194	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015194
GO_process	GO:0008654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008654
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GeneCards	SERINC4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SERINC4
GeneID	619189	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=619189
GeneTree	ENSGT00550000074522	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074522
H-InvDB	HIX0012191	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0012191
H-InvDB	HIX0079719	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0079719
HGNC	HGNC:32237	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:32237
HOGENOM	HOG000165463	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000165463&db=HOGENOM6
HOVERGEN	HBG025699	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG025699&db=HOVERGEN
HPA	HPA018526	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA018526
InParanoid	A6NH21	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=A6NH21
InterPro	IPR005016	http://www.ebi.ac.uk/interpro/entry/IPR005016
InterPro	IPR029563	http://www.ebi.ac.uk/interpro/entry/IPR029563
Jabion	619189	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=619189
KEGG_Gene	hsa:619189	http://www.genome.jp/dbget-bin/www_bget?hsa:619189
MIM	614550	http://www.ncbi.nlm.nih.gov/omim/614550
OMA	SWNKNWQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SWNKNWQ
OrthoDB	EOG091G06BW	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G06BW
PANTHER	PTHR10383	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10383
PANTHER	PTHR10383:SF5	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10383:SF5
PSORT	swissprot:SERC4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SERC4_HUMAN
PSORT-B	swissprot:SERC4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SERC4_HUMAN
PSORT2	swissprot:SERC4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SERC4_HUMAN
Pfam	PF03348	http://pfam.xfam.org/family/PF03348
PharmGKB	PA142670936	http://www.pharmgkb.org/do/serve?objId=PA142670936&objCls=Gene
Phobius	swissprot:SERC4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SERC4_HUMAN
PhylomeDB	A6NH21	http://phylomedb.org/?seqid=A6NH21
ProteinModelPortal	A6NH21	http://www.proteinmodelportal.org/query/uniprot/A6NH21
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16120614	http://www.ncbi.nlm.nih.gov/pubmed/16120614
PubMed	16572171	http://www.ncbi.nlm.nih.gov/pubmed/16572171
Reactome	R-HSA-977347	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-977347
RefSeq	NP_001244960	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001244960
RefSeq	NP_001244961	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001244961
SMR	A6NH21	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=A6NH21
STRING	9606.ENSP00000319796	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000319796&targetmode=cogs
UCSC	uc031qrp	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc031qrp&org=rat
UniGene	Hs.424126	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.424126
UniGene	Hs.604985	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.604985
UniProtKB	SERC4_HUMAN	http://www.uniprot.org/uniprot/SERC4_HUMAN
UniProtKB-AC	A6NH21	http://www.uniprot.org/uniprot/A6NH21
charge	swissprot:SERC4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SERC4_HUMAN
eggNOG	ENOG410XP7K	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XP7K
eggNOG	KOG2592	http://eggnogapi.embl.de/nog_data/html/tree/KOG2592
epestfind	swissprot:SERC4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SERC4_HUMAN
garnier	swissprot:SERC4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SERC4_HUMAN
helixturnhelix	swissprot:SERC4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SERC4_HUMAN
hmoment	swissprot:SERC4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SERC4_HUMAN
iep	swissprot:SERC4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SERC4_HUMAN
inforesidue	swissprot:SERC4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SERC4_HUMAN
neXtProt	NX_A6NH21	http://www.nextprot.org/db/entry/NX_A6NH21
octanol	swissprot:SERC4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SERC4_HUMAN
pepcoil	swissprot:SERC4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SERC4_HUMAN
pepdigest	swissprot:SERC4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SERC4_HUMAN
pepinfo	swissprot:SERC4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SERC4_HUMAN
pepnet	swissprot:SERC4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SERC4_HUMAN
pepstats	swissprot:SERC4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SERC4_HUMAN
pepwheel	swissprot:SERC4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SERC4_HUMAN
pepwindow	swissprot:SERC4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SERC4_HUMAN
sigcleave	swissprot:SERC4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SERC4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S39A8_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9C0K1-1; Sequence=Displayed; Name=2; IsoId=Q9C0K1-2; Sequence=VSP_029884, VSP_029885; Note=No experimental confirmation available.; Name=3; IsoId=Q9C0K1-3; Sequence=VSP_043675; Note=No experimental confirmation available.; 
# AltName	S39A8_HUMAN	BCG-induced integral membrane protein in monocyte clone 103 protein
# AltName	S39A8_HUMAN	LIV-1 subfamily of ZIP zinc transporter 6
# AltName	S39A8_HUMAN	Solute carrier family 39 member 8
# AltName	S39A8_HUMAN	Zrt- and Irt-like protein 8
# BioGrid	122072	26
# CCDS	CCDS3656	-. [Q9C0K1-1]
# CCDS	CCDS47117	-. [Q9C0K1-3]
# ChiTaRS	SLC39A8	human
# DISEASE	S39A8_HUMAN	Congenital disorder of glycosylation 2N (CDG2N) [MIM 616721]  A form of congenital disorder of glycosylation, a genetically heterogeneous group of autosomal recessive, multisystem disorders caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. {ECO 0000269|PubMed 26637978, ECO 0000269|PubMed 26637979}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000356736	ENSP00000349174; ENSG00000138821. [Q9C0K1-1]
# Ensembl	ENST00000394833	ENSP00000378310; ENSG00000138821. [Q9C0K1-1]
# Ensembl	ENST00000424970	ENSP00000394548; ENSG00000138821. [Q9C0K1-3]
# ExpressionAtlas	Q9C0K1	baseline and differential
# FUNCTION	S39A8_HUMAN	Acts as a manganese and zinc influx transporter (PubMed 12504855, PubMed 26637978). Plays a role in manganese reabsorption in the proximal tubule of the kidney and in manganese uptake into the brain (PubMed 26637978). {ECO 0000269|PubMed 12504855, ECO 0000305|PubMed 26637978}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0031090	organelle membrane; IDA:UniProtKB.
# GO_function	GO:0005385	zinc ion transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0006829	zinc II ion transport; IMP:UniProtKB.
# GO_process	GO:0006882	cellular zinc ion homeostasis; IBA:GO_Central.
# GO_process	GO:0070574	cadmium ion transmembrane transport; IEA:Ensembl.
# GO_process	GO:0071578	zinc II ion transmembrane import; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9C0K1	HS
# HGNC	HGNC:20862	SLC39A8
# INDUCTION	By live and heat-killed Mycobacterium bovis bacterial cell wall and inflammatory cytokines like TNF. Down-regulated following phorbol ester treatment. {ECO:0000269|PubMed	12504855}. 
# InterPro	IPR003689	ZIP
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H00119	[Inherited metabolic disease] Congenital disorders of glycosylation (CDG) type II
# MIM	608732	gene
# MIM	616721	phenotype
# Organism	S39A8_HUMAN	Homo sapiens (Human)
# Pfam	PF02535	Zip
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-442380	Zinc influx into cells by the SLC39 gene family
# RecName	S39A8_HUMAN	Zinc transporter ZIP8
# RefSeq	NP_001128618	NM_001135146.1. [Q9C0K1-1]
# RefSeq	NP_001128619	NM_001135147.1. [Q9C0K1-3]
# RefSeq	NP_001128620	NM_001135148.1. [Q9C0K1-2]
# RefSeq	NP_071437	NM_022154.5. [Q9C0K1-1]
# RefSeq	XP_005263234	XM_005263177.1. [Q9C0K1-1]
# RefSeq	XP_016864029	XM_017008540.1. [Q9C0K1-1]
# RefSeq	XP_016864030	XM_017008541.1. [Q9C0K1-2]
# SIMILARITY	Belongs to the ZIP transporter (TC 2.A.5) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S39A8_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. Note=Associated with the lysosomal/endosomal compartment following transfection. {ECO 0000269|PubMed 12504855}. 
# TCDB	2.A.5.4.15	the zinc (zn(2+))-iron (fe(2+)) permease (zip) family
# TISSUE SPECIFICITY	Expressed in thymus, placenta, lung, liver, pancreas and, to a lower extent, in spleen, testis, ovary, small intestine, colon, leukocyte, heart. Highest expression is observed in pancreas. {ECO:0000269|PubMed	12504855}. 
# UCSC	uc003hwb	human. [Q9C0K1-1]
# eggNOG	COG0428	LUCA
# eggNOG	KOG2693	Eukaryota
BLAST	swissprot:S39A8_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S39A8_HUMAN
BioCyc	ZFISH:ENSG00000138821-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000138821-MONOMER
COXPRESdb	64116	http://coxpresdb.jp/data/gene/64116.shtml
CleanEx	HS_SLC39A8	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC39A8
DOI	10.1006/geno.2002.7000	http://dx.doi.org/10.1006/geno.2002.7000
DOI	10.1016/j.ajhg.2015.11.002	http://dx.doi.org/10.1016/j.ajhg.2015.11.002
DOI	10.1016/j.ajhg.2015.11.003	http://dx.doi.org/10.1016/j.ajhg.2015.11.003
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0404089101	http://dx.doi.org/10.1073/pnas.0404089101
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB020970	http://www.ebi.ac.uk/ena/data/view/AB020970
EMBL	AB040120	http://www.ebi.ac.uk/ena/data/view/AB040120
EMBL	AC098487	http://www.ebi.ac.uk/ena/data/view/AC098487
EMBL	AF193052	http://www.ebi.ac.uk/ena/data/view/AF193052
EMBL	AK027652	http://www.ebi.ac.uk/ena/data/view/AK027652
EMBL	AK304274	http://www.ebi.ac.uk/ena/data/view/AK304274
EMBL	AP002023	http://www.ebi.ac.uk/ena/data/view/AP002023
EMBL	BC001320	http://www.ebi.ac.uk/ena/data/view/BC001320
EMBL	BC012125	http://www.ebi.ac.uk/ena/data/view/BC012125
EMBL	CH471057	http://www.ebi.ac.uk/ena/data/view/CH471057
Ensembl	ENST00000356736	http://www.ensembl.org/id/ENST00000356736
Ensembl	ENST00000394833	http://www.ensembl.org/id/ENST00000394833
Ensembl	ENST00000424970	http://www.ensembl.org/id/ENST00000424970
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0031090	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031090
GO_function	GO:0005385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005385
GO_process	GO:0006829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006829
GO_process	GO:0006882	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006882
GO_process	GO:0070574	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070574
GO_process	GO:0071578	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071578
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC39A8	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC39A8
GeneID	64116	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64116
GeneTree	ENSGT00760000119115	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119115
HGNC	HGNC:20862	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20862
HOGENOM	HOG000070225	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000070225&db=HOGENOM6
HOVERGEN	HBG108450	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108450&db=HOVERGEN
HPA	HPA038832	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA038832
HPA	HPA038833	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA038833
InParanoid	Q9C0K1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9C0K1
InterPro	IPR003689	http://www.ebi.ac.uk/interpro/entry/IPR003689
Jabion	64116	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=64116
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00119	http://www.genome.jp/dbget-bin/www_bget?H00119
KEGG_Gene	hsa:64116	http://www.genome.jp/dbget-bin/www_bget?hsa:64116
KEGG_Orthology	KO:K14714	http://www.genome.jp/dbget-bin/www_bget?KO:K14714
MIM	608732	http://www.ncbi.nlm.nih.gov/omim/608732
MIM	616721	http://www.ncbi.nlm.nih.gov/omim/616721
OMA	FFVERVL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FFVERVL
OrthoDB	EOG091G064Y	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G064Y
PSORT	swissprot:S39A8_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S39A8_HUMAN
PSORT-B	swissprot:S39A8_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S39A8_HUMAN
PSORT2	swissprot:S39A8_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S39A8_HUMAN
Pfam	PF02535	http://pfam.xfam.org/family/PF02535
PharmGKB	PA134931507	http://www.pharmgkb.org/do/serve?objId=PA134931507&objCls=Gene
Phobius	swissprot:S39A8_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S39A8_HUMAN
PhylomeDB	Q9C0K1	http://phylomedb.org/?seqid=Q9C0K1
ProteinModelPortal	Q9C0K1	http://www.proteinmodelportal.org/query/uniprot/Q9C0K1
PubMed	12504855	http://www.ncbi.nlm.nih.gov/pubmed/12504855
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15498874	http://www.ncbi.nlm.nih.gov/pubmed/15498874
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	26637978	http://www.ncbi.nlm.nih.gov/pubmed/26637978
PubMed	26637979	http://www.ncbi.nlm.nih.gov/pubmed/26637979
Reactome	R-HSA-442380	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442380
RefSeq	NP_001128618	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001128618
RefSeq	NP_001128619	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001128619
RefSeq	NP_001128620	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001128620
RefSeq	NP_071437	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_071437
RefSeq	XP_005263234	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005263234
RefSeq	XP_016864029	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016864029
RefSeq	XP_016864030	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016864030
SMR	Q9C0K1	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9C0K1
STRING	9606.ENSP00000349174	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000349174&targetmode=cogs
TCDB	2.A.5.4.15	http://www.tcdb.org/search/result.php?tc=2.A.5.4.15
UCSC	uc003hwb	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003hwb&org=rat
UniGene	Hs.288034	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.288034
UniProtKB	S39A8_HUMAN	http://www.uniprot.org/uniprot/S39A8_HUMAN
UniProtKB-AC	Q9C0K1	http://www.uniprot.org/uniprot/Q9C0K1
charge	swissprot:S39A8_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S39A8_HUMAN
eggNOG	COG0428	http://eggnogapi.embl.de/nog_data/html/tree/COG0428
eggNOG	KOG2693	http://eggnogapi.embl.de/nog_data/html/tree/KOG2693
epestfind	swissprot:S39A8_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S39A8_HUMAN
garnier	swissprot:S39A8_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S39A8_HUMAN
helixturnhelix	swissprot:S39A8_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S39A8_HUMAN
hmoment	swissprot:S39A8_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S39A8_HUMAN
iep	swissprot:S39A8_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S39A8_HUMAN
inforesidue	swissprot:S39A8_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S39A8_HUMAN
neXtProt	NX_Q9C0K1	http://www.nextprot.org/db/entry/NX_Q9C0K1
octanol	swissprot:S39A8_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S39A8_HUMAN
pepcoil	swissprot:S39A8_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S39A8_HUMAN
pepdigest	swissprot:S39A8_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S39A8_HUMAN
pepinfo	swissprot:S39A8_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S39A8_HUMAN
pepnet	swissprot:S39A8_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S39A8_HUMAN
pepstats	swissprot:S39A8_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S39A8_HUMAN
pepwheel	swissprot:S39A8_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S39A8_HUMAN
pepwindow	swissprot:S39A8_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S39A8_HUMAN
sigcleave	swissprot:S39A8_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S39A8_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AT1B1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P05026-1; Sequence=Displayed; Name=2; IsoId=P05026-2; Sequence=VSP_000349; 
# AltName	AT1B1_HUMAN	Sodium/potassium-dependent ATPase subunit beta-1
# BioGrid	106971	72
# CCDS	CCDS1276	-. [P05026-1]
# ChiTaRS	ATP1B1	human
# DOMAIN	AT1B1_HUMAN	The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties. {ECO 0000250}. 
# Ensembl	ENST00000367815	ENSP00000356789; ENSG00000143153. [P05026-1]
# Ensembl	ENST00000367816	ENSP00000356790; ENSG00000143153. [P05026-1]
# ExpressionAtlas	P05026	baseline and differential
# FUNCTION	AT1B1_HUMAN	Involved in cell adhesion and establishing epithelial cell polarity. {ECO 0000269|PubMed 19694409}. 
# FUNCTION	AT1B1_HUMAN	This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. {ECO 0000269|PubMed 19694409}. 
# GO_component	AT1B1_HUMAN	GO 0005890 sodium potassium-exchanging ATPase complex; IDA BHF-UCL.
# GO_component	GO:0005622	intracellular; IEA:GOC.
# GO_component	GO:0005886	plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0005901	caveola; IEA:Ensembl.
# GO_component	GO:0014704	intercalated disc; ISS:BHF-UCL.
# GO_component	GO:0016020	membrane; IDA:BHF-UCL.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:Ensembl.
# GO_component	GO:0016324	apical plasma membrane; IEA:Ensembl.
# GO_component	GO:0042383	sarcolemma; ISS:BHF-UCL.
# GO_component	GO:0043209	myelin sheath; IEA:Ensembl.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_component	GO:1903561	extracellular vesicle; IDA:UniProtKB.
# GO_function	AT1B1_HUMAN	GO 0005391 sodium potassium-exchanging ATPase activity; IEA Ensembl.
# GO_function	GO:0001671	ATPase activator activity; IDA:BHF-UCL.
# GO_function	GO:0023026	MHC class II protein complex binding; IDA:UniProtKB.
# GO_function	GO:0051117	ATPase binding; IPI:BHF-UCL.
# GO_process	AT1B1_HUMAN	GO 1903281 positive regulation of calcium sodium antiporter activity; ISS BHF-UCL.
# GO_process	GO:0001666	response to hypoxia; IEA:Ensembl.
# GO_process	GO:0006874	cellular calcium ion homeostasis; ISS:BHF-UCL.
# GO_process	GO:0006883	cellular sodium ion homeostasis; IDA:BHF-UCL.
# GO_process	GO:0007155	cell adhesion; IEA:UniProtKB-KW.
# GO_process	GO:0010107	potassium ion import; IDA:BHF-UCL.
# GO_process	GO:0010468	regulation of gene expression; ISS:BHF-UCL.
# GO_process	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling; ISS:BHF-UCL.
# GO_process	GO:0030007	cellular potassium ion homeostasis; IDA:BHF-UCL.
# GO_process	GO:0032781	positive regulation of ATPase activity; IDA:BHF-UCL.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0036376	sodium ion export from cell; IDA:BHF-UCL.
# GO_process	GO:0044861	protein transport into plasma membrane raft; TAS:BHF-UCL.
# GO_process	GO:0046034	ATP metabolic process; IDA:BHF-UCL.
# GO_process	GO:0050821	protein stabilization; IDA:BHF-UCL.
# GO_process	GO:0050900	leukocyte migration; TAS:Reactome.
# GO_process	GO:0055119	relaxation of cardiac muscle; ISS:BHF-UCL.
# GO_process	GO:0060048	cardiac muscle contraction; ISS:BHF-UCL.
# GO_process	GO:0072659	protein localization to plasma membrane; IDA:BHF-UCL.
# GO_process	GO:0086009	membrane repolarization; IDA:BHF-UCL.
# GO_process	GO:0086013	membrane repolarization during cardiac muscle cell action potential; IC:BHF-UCL.
# GO_process	GO:0086064	cell communication by electrical coupling involved in cardiac conduction; TAS:BHF-UCL.
# GO_process	GO:1901018	positive regulation of potassium ion transmembrane transporter activity; IDA:BHF-UCL.
# GO_process	GO:1903278	positive regulation of sodium ion export from cell; IDA:BHF-UCL.
# GO_process	GO:1903288	positive regulation of potassium ion import; IDA:BHF-UCL.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GO_process	GO:1990573	potassium ion import across plasma membrane; ISS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005622	intracellular
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0030234	enzyme regulator activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007009	plasma membrane organization
# GOslim_process	GO:0007155	cell adhesion
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0048870	cell motility
# GOslim_process	GO:0055085	transmembrane transport
# GOslim_process	GO:0061024	membrane organization
# Genevisible	P05026	HS
# HGNC	HGNC:804	ATP1B1
# INTERACTION	AT1B1_HUMAN	P02730 SLC4A1; NbExp=8; IntAct=EBI-714630, EBI-7576138; 
# IntAct	P05026	14
# InterPro	IPR000402	Na/K_ATPase_sub_beta
# InterPro	IPR015565	Na/K_ATPase_sub_beta_chordates
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04090	 Cellular antigens
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko04960	Aldosterone-regulated sodium reabsorption
# KEGG_Pathway	ko04961	Endocrine and other factor-regulated calcium reabsorption
# KEGG_Pathway	ko04964	Proximal tubule bicarbonate reclamation
# KEGG_Pathway	ko04970	Salivary secretion
# KEGG_Pathway	ko04971	Gastric acid secretion
# KEGG_Pathway	ko04972	Pancreatic secretion
# KEGG_Pathway	ko04973	Carbohydrate digestion and absorption
# KEGG_Pathway	ko04974	Protein digestion and absorption
# KEGG_Pathway	ko04976	Bile secretion
# KEGG_Pathway	ko04978	Mineral absorption
# MIM	182330	gene
# Organism	AT1B1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11523	PTHR11523
# PANTHER	PTHR11523:SF10	PTHR11523:SF10
# PIR	A23764	PWHUNB
# PROSITE	PS00390	ATPASE_NA_K_BETA_1
# PROSITE	PS00391	ATPASE_NA_K_BETA_2
# Pfam	PF00287	Na_K-ATPase
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-210991	Basigin interactions
# Reactome	R-HSA-5578775	Ion homeostasis
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	AT1B1_HUMAN	Sodium/potassium-transporting ATPase subunit beta-1
# RefSeq	NP_001668	NM_001677.3. [P05026-1]
# SIMILARITY	Belongs to the X(+)/potassium ATPases subunit beta family. {ECO	0000305}.
# SUBCELLULAR LOCATION	AT1B1_HUMAN	Cell membrane; Single-pass type II membrane protein. 
# SUBUNIT	AT1B1_HUMAN	Composed of three subunits  alpha (catalytic), beta and gamma. Interacts with NKAIN1, NKAIN2 and NKAIN4 (By similarity). Interacts with MLC1 (PubMed 22328087). Part of a complex containing MLC1, TRPV4, AQP4 and HEPACAM. Interacts with KIRREL3 (PubMed 25902260). {ECO 0000250, ECO 0000269|PubMed 22328087, ECO 0000269|PubMed 25902260}. 
# TCDB	3.A.3.1	the p-type atpase (p-atpase) superfamily
# TIGRFAMs	TIGR01107	Na_K_ATPase_bet
# TISSUE SPECIFICITY	AT1B1_HUMAN	Found in most tissues. 
# UCSC	uc001gfr	human. [P05026-1]
# eggNOG	ENOG411150A	LUCA
# eggNOG	KOG3927	Eukaryota
BLAST	swissprot:AT1B1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AT1B1_HUMAN
BioCyc	ZFISH:HS06994-MONOMER	http://biocyc.org/getid?id=ZFISH:HS06994-MONOMER
COXPRESdb	481	http://coxpresdb.jp/data/gene/481.shtml
CleanEx	HS_ATP1B1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP1B1
DOI	10.1016/0014-5793(89)81591-1	http://dx.doi.org/10.1016/0014-5793(89)81591-1
DOI	10.1016/0378-1119(94)00812-7	http://dx.doi.org/10.1016/0378-1119(94)00812-7
DOI	10.1016/0888-7543(89)90008-6	http://dx.doi.org/10.1016/0888-7543(89)90008-6
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/bi900868e	http://dx.doi.org/10.1021/bi900868e
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/nbt.1532	http://dx.doi.org/10.1038/nbt.1532
DOI	10.1038/nbt827	http://dx.doi.org/10.1038/nbt827
DOI	10.1093/hmg/dds032	http://dx.doi.org/10.1093/hmg/dds032
DOI	10.1093/nar/14.7.2833	http://dx.doi.org/10.1093/nar/14.7.2833
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1371/journal.pone.0123106	http://dx.doi.org/10.1371/journal.pone.0123106
EMBL	AL031726	http://www.ebi.ac.uk/ena/data/view/AL031726
EMBL	BC000006	http://www.ebi.ac.uk/ena/data/view/BC000006
EMBL	BT009787	http://www.ebi.ac.uk/ena/data/view/BT009787
EMBL	M25160	http://www.ebi.ac.uk/ena/data/view/M25160
EMBL	M25161	http://www.ebi.ac.uk/ena/data/view/M25161
EMBL	U16799	http://www.ebi.ac.uk/ena/data/view/U16799
EMBL	X03747	http://www.ebi.ac.uk/ena/data/view/X03747
EMBL	X17161	http://www.ebi.ac.uk/ena/data/view/X17161
Ensembl	ENST00000367815	http://www.ensembl.org/id/ENST00000367815
Ensembl	ENST00000367816	http://www.ensembl.org/id/ENST00000367816
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005890
GO_component	GO:0005901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005901
GO_component	GO:0014704	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014704
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0042383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042383
GO_component	GO:0043209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043209
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_component	GO:1903561	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903561
GO_function	GO:0001671	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001671
GO_function	GO:0005391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005391
GO_function	GO:0023026	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0023026
GO_function	GO:0051117	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051117
GO_process	GO:0001666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001666
GO_process	GO:0006874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874
GO_process	GO:0006883	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006883
GO_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GO_process	GO:0010107	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010107
GO_process	GO:0010468	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010468
GO_process	GO:0010882	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010882
GO_process	GO:0030007	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030007
GO_process	GO:0032781	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032781
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0036376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036376
GO_process	GO:0044861	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044861
GO_process	GO:0046034	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046034
GO_process	GO:0050821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050821
GO_process	GO:0050900	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050900
GO_process	GO:0055119	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055119
GO_process	GO:0060048	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060048
GO_process	GO:0072659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072659
GO_process	GO:0086009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086009
GO_process	GO:0086013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086013
GO_process	GO:0086064	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086064
GO_process	GO:1901018	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901018
GO_process	GO:1903278	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903278
GO_process	GO:1903281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903281
GO_process	GO:1903288	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903288
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GO_process	GO:1990573	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990573
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0030234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007009
GOslim_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
GeneCards	ATP1B1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP1B1
GeneID	481	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=481
GeneTree	ENSGT00550000074530	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074530
H-InvDB	HIX0001311	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0001311
HGNC	HGNC:804	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:804
HOGENOM	HOG000039248	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000039248&db=HOGENOM6
HOVERGEN	HBG050603	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050603&db=HOVERGEN
HPA	HPA012911	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA012911
InParanoid	P05026	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P05026
IntAct	P05026	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P05026*
InterPro	IPR000402	http://www.ebi.ac.uk/interpro/entry/IPR000402
InterPro	IPR015565	http://www.ebi.ac.uk/interpro/entry/IPR015565
Jabion	481	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=481
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04090	http://www.genome.jp/dbget-bin/www_bget?ko04090
KEGG_Gene	hsa:481	http://www.genome.jp/dbget-bin/www_bget?hsa:481
KEGG_Orthology	KO:K01540	http://www.genome.jp/dbget-bin/www_bget?KO:K01540
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko04960	http://www.genome.jp/kegg-bin/show_pathway?ko04960
KEGG_Pathway	ko04961	http://www.genome.jp/kegg-bin/show_pathway?ko04961
KEGG_Pathway	ko04964	http://www.genome.jp/kegg-bin/show_pathway?ko04964
KEGG_Pathway	ko04970	http://www.genome.jp/kegg-bin/show_pathway?ko04970
KEGG_Pathway	ko04971	http://www.genome.jp/kegg-bin/show_pathway?ko04971
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
KEGG_Pathway	ko04973	http://www.genome.jp/kegg-bin/show_pathway?ko04973
KEGG_Pathway	ko04974	http://www.genome.jp/kegg-bin/show_pathway?ko04974
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
KEGG_Pathway	ko04978	http://www.genome.jp/kegg-bin/show_pathway?ko04978
MIM	182330	http://www.ncbi.nlm.nih.gov/omim/182330
MINT	MINT-5000887	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5000887
OMA	RGEFNNE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RGEFNNE
OrthoDB	EOG091G0DJ4	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0DJ4
PANTHER	PTHR11523	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11523
PANTHER	PTHR11523:SF10	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11523:SF10
PROSITE	PS00390	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00390
PROSITE	PS00391	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00391
PSORT	swissprot:AT1B1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AT1B1_HUMAN
PSORT-B	swissprot:AT1B1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AT1B1_HUMAN
PSORT2	swissprot:AT1B1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AT1B1_HUMAN
Pfam	PF00287	http://pfam.xfam.org/family/PF00287
PharmGKB	PA66	http://www.pharmgkb.org/do/serve?objId=PA66&objCls=Gene
Phobius	swissprot:AT1B1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AT1B1_HUMAN
PhylomeDB	P05026	http://phylomedb.org/?seqid=P05026
ProteinModelPortal	P05026	http://www.proteinmodelportal.org/query/uniprot/P05026
PubMed	12754519	http://www.ncbi.nlm.nih.gov/pubmed/12754519
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	19349973	http://www.ncbi.nlm.nih.gov/pubmed/19349973
PubMed	19694409	http://www.ncbi.nlm.nih.gov/pubmed/19694409
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22328087	http://www.ncbi.nlm.nih.gov/pubmed/22328087
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	2555225	http://www.ncbi.nlm.nih.gov/pubmed/2555225
PubMed	2559024	http://www.ncbi.nlm.nih.gov/pubmed/2559024
PubMed	25902260	http://www.ncbi.nlm.nih.gov/pubmed/25902260
PubMed	3008098	http://www.ncbi.nlm.nih.gov/pubmed/3008098
PubMed	7536695	http://www.ncbi.nlm.nih.gov/pubmed/7536695
Reactome	R-HSA-210991	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-210991
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_001668	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001668
STRING	9606.ENSP00000356789	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000356789&targetmode=cogs
TCDB	3.A.3.1	http://www.tcdb.org/search/result.php?tc=3.A.3.1
TIGRFAMs	TIGR01107	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01107
UCSC	uc001gfr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001gfr&org=rat
UniGene	Hs.291196	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.291196
UniProtKB	AT1B1_HUMAN	http://www.uniprot.org/uniprot/AT1B1_HUMAN
UniProtKB-AC	P05026	http://www.uniprot.org/uniprot/P05026
charge	swissprot:AT1B1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AT1B1_HUMAN
eggNOG	ENOG411150A	http://eggnogapi.embl.de/nog_data/html/tree/ENOG411150A
eggNOG	KOG3927	http://eggnogapi.embl.de/nog_data/html/tree/KOG3927
epestfind	swissprot:AT1B1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AT1B1_HUMAN
garnier	swissprot:AT1B1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AT1B1_HUMAN
helixturnhelix	swissprot:AT1B1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AT1B1_HUMAN
hmoment	swissprot:AT1B1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AT1B1_HUMAN
iep	swissprot:AT1B1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AT1B1_HUMAN
inforesidue	swissprot:AT1B1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AT1B1_HUMAN
neXtProt	NX_P05026	http://www.nextprot.org/db/entry/NX_P05026
octanol	swissprot:AT1B1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AT1B1_HUMAN
pepcoil	swissprot:AT1B1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AT1B1_HUMAN
pepdigest	swissprot:AT1B1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AT1B1_HUMAN
pepinfo	swissprot:AT1B1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AT1B1_HUMAN
pepnet	swissprot:AT1B1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AT1B1_HUMAN
pepstats	swissprot:AT1B1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AT1B1_HUMAN
pepwheel	swissprot:AT1B1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AT1B1_HUMAN
pepwindow	swissprot:AT1B1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AT1B1_HUMAN
sigcleave	swissprot:AT1B1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AT1B1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNN3_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9UGI6-1; Sequence=Displayed; Name=2; IsoId=Q9UGI6-2; Sequence=VSP_039461, VSP_039462; Name=3; Synonyms=SK3-1B; IsoId=Q9UGI6-3; Sequence=VSP_047641; Note=Do not produce functional channels, but selectively suppresses endogenous SK3 currents, in a dominant-negative fashion. This dominant inhibitory effect extends to other members of the SK subfamily. Widely distributed in human tissues and is present at 20-60% of SK3 in the brain.; 
# AltName	KCNN3_HUMAN	KCa2.3
# BioGrid	109983	5
# CCDS	CCDS1072	-. [Q9UGI6-2]
# ChiTaRS	KCNN3	human
# DrugBank	DB00721	Procaine
# DrugBank	DB01110	Miconazole
# Ensembl	ENST00000358505	ENSP00000351295; ENSG00000143603. [Q9UGI6-3]
# Ensembl	ENST00000361147	ENSP00000354764; ENSG00000143603. [Q9UGI6-2]
# ExpressionAtlas	Q9UGI6	baseline and differential
# FUNCTION	KCNN3_HUMAN	Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. 
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0043025	neuronal cell body; IBA:GO_Central.
# GO_function	GO:0005516	calmodulin binding; IBA:GO_Central.
# GO_function	GO:0016286	small conductance calcium-activated potassium channel activity; IBA:GO_Central.
# GO_process	GO:1903955	positive regulation of protein targeting to mitochondrion; IMP:ParkinsonsUK-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q9UGI6	HS
# HGNC	HGNC:6292	KCNN3
# InterPro	IPR004178	CaM-bd_dom
# InterPro	IPR013099	K_chnl_dom
# InterPro	IPR015449	K_chnl_Ca-activ_SK
# KEGG_Brite	ko04040	Ion channels
# MIM	602983	gene
# Organism	KCNN3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10153	PTHR10153
# POLYMORPHISM	The second poly-Gln region of KCNN3 is highly polymorphic and the number of Gln varies from 12 to 28 in the population. {ECO:0000269|PubMed	9491810}. 
# PRINTS	PR01451	SKCHANNEL
# Pfam	PF02888	CaMBD
# Pfam	PF03530	SK_channel
# Pfam	PF07885	Ion_trans_2
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-1296052	Ca2+ activated K+ channels
# RecName	KCNN3_HUMAN	Small conductance calcium-activated potassium channel protein 3
# RefSeq	NP_001191016	NM_001204087.1
# RefSeq	NP_002240	NM_002249.5
# RefSeq	NP_740752	NM_170782.2. [Q9UGI6-2]
# SIMILARITY	Belongs to the potassium channel KCNN family. KCa2.3/KCNN3 subfamily. {ECO	0000305}.
# SMART	SM01053	CaMBD
# SUBCELLULAR LOCATION	KCNN3_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity). {ECO	0000250}. 
# SUPFAM	SSF81327	SSF81327
# UCSC	uc001ffo	human. [Q9UGI6-1]
# eggNOG	ENOG410XT9D	LUCA
# eggNOG	KOG3684	Eukaryota
BLAST	swissprot:KCNN3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNN3_HUMAN
BioCyc	ZFISH:ENSG00000143603-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000143603-MONOMER
COXPRESdb	3782	http://coxpresdb.jp/data/gene/3782.shtml
CleanEx	HS_KCNN3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNN3
DOI	10.1007/s100380170046	http://dx.doi.org/10.1007/s100380170046
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/sj.mp.4000353	http://dx.doi.org/10.1038/sj.mp.4000353
DOI	10.1038/sj.mp.4001271	http://dx.doi.org/10.1038/sj.mp.4001271
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00721	http://www.drugbank.ca/drugs/DB00721
DrugBank	DB01110	http://www.drugbank.ca/drugs/DB01110
EMBL	AF031815	http://www.ebi.ac.uk/ena/data/view/AF031815
EMBL	AF336797	http://www.ebi.ac.uk/ena/data/view/AF336797
EMBL	AF438203	http://www.ebi.ac.uk/ena/data/view/AF438203
EMBL	AJ251016	http://www.ebi.ac.uk/ena/data/view/AJ251016
EMBL	AL390204	http://www.ebi.ac.uk/ena/data/view/AL390204
EMBL	AL390204	http://www.ebi.ac.uk/ena/data/view/AL390204
EMBL	AL390204	http://www.ebi.ac.uk/ena/data/view/AL390204
EMBL	AL390204	http://www.ebi.ac.uk/ena/data/view/AL390204
EMBL	AL390204	http://www.ebi.ac.uk/ena/data/view/AL390204
EMBL	AL390204	http://www.ebi.ac.uk/ena/data/view/AL390204
EMBL	AL606500	http://www.ebi.ac.uk/ena/data/view/AL606500
EMBL	AL606500	http://www.ebi.ac.uk/ena/data/view/AL606500
EMBL	AL606500	http://www.ebi.ac.uk/ena/data/view/AL606500
EMBL	AL606500	http://www.ebi.ac.uk/ena/data/view/AL606500
EMBL	AL606500	http://www.ebi.ac.uk/ena/data/view/AL606500
EMBL	AL606500	http://www.ebi.ac.uk/ena/data/view/AL606500
EMBL	AL954342	http://www.ebi.ac.uk/ena/data/view/AL954342
EMBL	AL954342	http://www.ebi.ac.uk/ena/data/view/AL954342
EMBL	AL954342	http://www.ebi.ac.uk/ena/data/view/AL954342
EMBL	AL954342	http://www.ebi.ac.uk/ena/data/view/AL954342
EMBL	AL954342	http://www.ebi.ac.uk/ena/data/view/AL954342
EMBL	AL954342	http://www.ebi.ac.uk/ena/data/view/AL954342
EMBL	AY138900	http://www.ebi.ac.uk/ena/data/view/AY138900
EMBL	BC042147	http://www.ebi.ac.uk/ena/data/view/BC042147
EMBL	CH471121	http://www.ebi.ac.uk/ena/data/view/CH471121
EMBL	CH471121	http://www.ebi.ac.uk/ena/data/view/CH471121
Ensembl	ENST00000358505	http://www.ensembl.org/id/ENST00000358505
Ensembl	ENST00000361147	http://www.ensembl.org/id/ENST00000361147
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_function	GO:0005516	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005516
GO_function	GO:0016286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016286
GO_process	GO:1903955	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903955
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	KCNN3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNN3
GeneID	3782	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3782
GeneTree	ENSGT00500000044784	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00500000044784
H-InvDB	HIX0023527	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0023527
HGNC	HGNC:6292	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6292
HOGENOM	HOG000276908	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276908&db=HOGENOM6
HOVERGEN	HBG052241	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052241&db=HOVERGEN
HPA	HPA017990	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA017990
HPA	HPA057127	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA057127
InParanoid	Q9UGI6	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UGI6
InterPro	IPR004178	http://www.ebi.ac.uk/interpro/entry/IPR004178
InterPro	IPR013099	http://www.ebi.ac.uk/interpro/entry/IPR013099
InterPro	IPR015449	http://www.ebi.ac.uk/interpro/entry/IPR015449
Jabion	3782	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3782
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3782	http://www.genome.jp/dbget-bin/www_bget?hsa:3782
KEGG_Orthology	KO:K04944	http://www.genome.jp/dbget-bin/www_bget?KO:K04944
MIM	602983	http://www.ncbi.nlm.nih.gov/omim/602983
PANTHER	PTHR10153	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10153
PRINTS	PR01451	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01451
PSORT	swissprot:KCNN3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNN3_HUMAN
PSORT-B	swissprot:KCNN3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNN3_HUMAN
PSORT2	swissprot:KCNN3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNN3_HUMAN
Pfam	PF02888	http://pfam.xfam.org/family/PF02888
Pfam	PF03530	http://pfam.xfam.org/family/PF03530
Pfam	PF07885	http://pfam.xfam.org/family/PF07885
PharmGKB	PA30072	http://www.pharmgkb.org/do/serve?objId=PA30072&objCls=Gene
Phobius	swissprot:KCNN3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNN3_HUMAN
PhylomeDB	Q9UGI6	http://phylomedb.org/?seqid=Q9UGI6
ProteinModelPortal	Q9UGI6	http://www.proteinmodelportal.org/query/uniprot/Q9UGI6
PubMed	11501944	http://www.ncbi.nlm.nih.gov/pubmed/11501944
PubMed	12808432	http://www.ncbi.nlm.nih.gov/pubmed/12808432
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	9491810	http://www.ncbi.nlm.nih.gov/pubmed/9491810
Reactome	R-HSA-1296052	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296052
RefSeq	NP_001191016	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001191016
RefSeq	NP_002240	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002240
RefSeq	NP_740752	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_740752
SMART	SM01053	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01053
SMR	Q9UGI6	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9UGI6
STRING	9606.ENSP00000271915	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000271915&targetmode=cogs
SUPFAM	SSF81327	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81327
UCSC	uc001ffo	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001ffo&org=rat
UniGene	Hs.490765	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.490765
UniProtKB	KCNN3_HUMAN	http://www.uniprot.org/uniprot/KCNN3_HUMAN
UniProtKB-AC	Q9UGI6	http://www.uniprot.org/uniprot/Q9UGI6
charge	swissprot:KCNN3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNN3_HUMAN
eggNOG	ENOG410XT9D	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XT9D
eggNOG	KOG3684	http://eggnogapi.embl.de/nog_data/html/tree/KOG3684
epestfind	swissprot:KCNN3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNN3_HUMAN
garnier	swissprot:KCNN3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNN3_HUMAN
helixturnhelix	swissprot:KCNN3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNN3_HUMAN
hmoment	swissprot:KCNN3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNN3_HUMAN
iep	swissprot:KCNN3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNN3_HUMAN
inforesidue	swissprot:KCNN3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNN3_HUMAN
neXtProt	NX_Q9UGI6	http://www.nextprot.org/db/entry/NX_Q9UGI6
octanol	swissprot:KCNN3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNN3_HUMAN
pepcoil	swissprot:KCNN3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNN3_HUMAN
pepdigest	swissprot:KCNN3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNN3_HUMAN
pepinfo	swissprot:KCNN3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNN3_HUMAN
pepnet	swissprot:KCNN3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNN3_HUMAN
pepstats	swissprot:KCNN3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNN3_HUMAN
pepwheel	swissprot:KCNN3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNN3_HUMAN
pepwindow	swissprot:KCNN3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNN3_HUMAN
sigcleave	swissprot:KCNN3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNN3_HUMAN
## Database	ID	URL or Descriptions
# AltName	SC5A5_HUMAN	Sodium-iodide symporter
# AltName	SC5A5_HUMAN	Solute carrier family 5 member 5
# BioGrid	112419	11
# ChiTaRS	SLC5A5	human
# DISEASE	SC5A5_HUMAN	Thyroid dyshormonogenesis 1 (TDH1) [MIM 274400]  A disorder characterized by the inability of the thyroid to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland, leading to congenital hypothyroidism. {ECO 0000269|PubMed 10487695, ECO 0000269|PubMed 9171822, ECO 0000269|PubMed 9486973, ECO 0000269|PubMed 9745458}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000222248	ENSP00000222248; ENSG00000105641
# FUNCTION	SC5A5_HUMAN	Mediates iodide uptake in the thyroid gland. 
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_component	GO:1903561	extracellular vesicle; IDA:UniProtKB.
# GO_function	GO:0015111	iodide transmembrane transporter activity; IMP:UniProtKB.
# GO_function	SC5A5_HUMAN	GO 0008507 sodium iodide symporter activity; IBA GO_Central.
# GO_process	GO:0006590	thyroid hormone generation; IBA:GO_Central.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0015705	iodide transport; IMP:UniProtKB.
# GO_process	GO:0071320	cellular response to cAMP; IEP:UniProtKB.
# GO_process	GO:0071371	cellular response to gonadotropin stimulus; IEP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q92911	HS
# HGNC	HGNC:11040	SLC5A5
# InterPro	IPR001734	Na/solute_symporter
# InterPro	IPR018212	Na/solute_symporter_CS
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H00251	[Endocrine disease] Dyshormogenetic goiter
# MIM	274400	phenotype
# MIM	601843	gene
# Organism	SC5A5_HUMAN	Homo sapiens (Human)
# Orphanet	95716	Familial thyroid dyshormonogenesis
# PANTHER	PTHR11819	PTHR11819; 2
# PIR	JC4974	JC4974
# PROSITE	PS00456	NA_SOLUT_SYMP_1
# PROSITE	PS50283	NA_SOLUT_SYMP_3
# Pfam	PF00474	SSF
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-209968	Thyroxine biosynthesis
# Reactome	R-HSA-428643	Organic anion transporters
# RecName	SC5A5_HUMAN	Sodium/iodide cotransporter
# RefSeq	NP_000444	NM_000453.2
# SIMILARITY	Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	SC5A5_HUMAN	Membrane; Multi-pass membrane protein. 
# TCDB	2.A.21.5:the solute	sodium symporter (sss) family
# TIGRFAMs	TIGR00813	sss
# TISSUE SPECIFICITY	SC5A5_HUMAN	Expression is primarily in thyroid tissue, but also to a lower extent in mammary gland and ovary. Expression is reduced in tumors. {ECO 0000269|PubMed 8806637, ECO 0000269|PubMed 9329364}. 
# UCSC	uc002nhr	human
# WEB RESOURCE	SC5A5_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/SLC5A5ID44476ch19p13.html";
# eggNOG	COG0591	LUCA
# eggNOG	KOG2349	Eukaryota
BLAST	swissprot:SC5A5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SC5A5_HUMAN
BioCyc	ZFISH:ENSG00000105641-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000105641-MONOMER
COXPRESdb	6528	http://coxpresdb.jp/data/gene/6528.shtml
CleanEx	HS_SLC5A5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC5A5
DOI	10.1006/bbrc.1996.1358	http://dx.doi.org/10.1006/bbrc.1996.1358
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DOI	10.1038/ng0697-124	http://dx.doi.org/10.1038/ng0697-124
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1172/JCI1504	http://dx.doi.org/10.1172/JCI1504
DOI	10.1210/jc.82.10.3331	http://dx.doi.org/10.1210/jc.82.10.3331
DOI	10.1210/jc.83.9.3365	http://dx.doi.org/10.1210/jc.83.9.3365
DOI	10.1210/jc.84.9.3248	http://dx.doi.org/10.1210/jc.84.9.3248
EMBL	AC005796	http://www.ebi.ac.uk/ena/data/view/AC005796
EMBL	AF260700	http://www.ebi.ac.uk/ena/data/view/AF260700
EMBL	BC105047	http://www.ebi.ac.uk/ena/data/view/BC105047
EMBL	BC105049	http://www.ebi.ac.uk/ena/data/view/BC105049
EMBL	D87920	http://www.ebi.ac.uk/ena/data/view/D87920
EMBL	U66088	http://www.ebi.ac.uk/ena/data/view/U66088
Ensembl	ENST00000222248	http://www.ensembl.org/id/ENST00000222248
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_component	GO:1903561	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903561
GO_function	GO:0008507	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008507
GO_function	GO:0015111	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015111
GO_process	GO:0006590	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006590
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0015705	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015705
GO_process	GO:0071320	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071320
GO_process	GO:0071371	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071371
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	SLC5A5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC5A5
GeneID	6528	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6528
GeneTree	ENSGT00760000118955	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118955
HGNC	HGNC:11040	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11040
HOGENOM	HOG000261662	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261662&db=HOGENOM6
HOVERGEN	HBG057280	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG057280&db=HOVERGEN
HPA	CAB022364	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB022364
HPA	HPA049055	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA049055
InParanoid	Q92911	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q92911
IntAct	Q92911	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q92911*
InterPro	IPR001734	http://www.ebi.ac.uk/interpro/entry/IPR001734
InterPro	IPR018212	http://www.ebi.ac.uk/interpro/entry/IPR018212
Jabion	6528	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6528
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00251	http://www.genome.jp/dbget-bin/www_bget?H00251
KEGG_Gene	hsa:6528	http://www.genome.jp/dbget-bin/www_bget?hsa:6528
KEGG_Orthology	KO:K14385	http://www.genome.jp/dbget-bin/www_bget?KO:K14385
MIM	274400	http://www.ncbi.nlm.nih.gov/omim/274400
MIM	601843	http://www.ncbi.nlm.nih.gov/omim/601843
OMA	ATFGAWD	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ATFGAWD
Orphanet	95716	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=95716
OrthoDB	EOG091G07OC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07OC
PANTHER	PTHR11819	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11819
PROSITE	PS00456	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00456
PROSITE	PS50283	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50283
PSORT	swissprot:SC5A5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SC5A5_HUMAN
PSORT-B	swissprot:SC5A5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SC5A5_HUMAN
PSORT2	swissprot:SC5A5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SC5A5_HUMAN
Pfam	PF00474	http://pfam.xfam.org/family/PF00474
PharmGKB	PA35905	http://www.pharmgkb.org/do/serve?objId=PA35905&objCls=Gene
Phobius	swissprot:SC5A5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SC5A5_HUMAN
PhylomeDB	Q92911	http://phylomedb.org/?seqid=Q92911
ProteinModelPortal	Q92911	http://www.proteinmodelportal.org/query/uniprot/Q92911
PubMed	10487695	http://www.ncbi.nlm.nih.gov/pubmed/10487695
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	8806637	http://www.ncbi.nlm.nih.gov/pubmed/8806637
PubMed	9171822	http://www.ncbi.nlm.nih.gov/pubmed/9171822
PubMed	9329364	http://www.ncbi.nlm.nih.gov/pubmed/9329364
PubMed	9486973	http://www.ncbi.nlm.nih.gov/pubmed/9486973
PubMed	9745458	http://www.ncbi.nlm.nih.gov/pubmed/9745458
Reactome	R-HSA-209968	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-209968
Reactome	R-HSA-428643	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428643
RefSeq	NP_000444	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000444
STRING	9606.ENSP00000222248	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000222248&targetmode=cogs
TCDB	2.A.21.5	http://www.tcdb.org/search/result.php?tc=2.A.21.5
TIGRFAMs	TIGR00813	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00813
UCSC	uc002nhr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002nhr&org=rat
UniGene	Hs.584804	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.584804
UniProtKB	SC5A5_HUMAN	http://www.uniprot.org/uniprot/SC5A5_HUMAN
UniProtKB-AC	Q92911	http://www.uniprot.org/uniprot/Q92911
charge	swissprot:SC5A5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SC5A5_HUMAN
eggNOG	COG0591	http://eggnogapi.embl.de/nog_data/html/tree/COG0591
eggNOG	KOG2349	http://eggnogapi.embl.de/nog_data/html/tree/KOG2349
epestfind	swissprot:SC5A5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SC5A5_HUMAN
garnier	swissprot:SC5A5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SC5A5_HUMAN
helixturnhelix	swissprot:SC5A5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SC5A5_HUMAN
hmoment	swissprot:SC5A5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SC5A5_HUMAN
iep	swissprot:SC5A5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SC5A5_HUMAN
inforesidue	swissprot:SC5A5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SC5A5_HUMAN
neXtProt	NX_Q92911	http://www.nextprot.org/db/entry/NX_Q92911
octanol	swissprot:SC5A5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SC5A5_HUMAN
pepcoil	swissprot:SC5A5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SC5A5_HUMAN
pepdigest	swissprot:SC5A5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SC5A5_HUMAN
pepinfo	swissprot:SC5A5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SC5A5_HUMAN
pepnet	swissprot:SC5A5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SC5A5_HUMAN
pepstats	swissprot:SC5A5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SC5A5_HUMAN
pepwheel	swissprot:SC5A5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SC5A5_HUMAN
pepwindow	swissprot:SC5A5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SC5A5_HUMAN
sigcleave	swissprot:SC5A5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SC5A5_HUMAN
## Database	ID	URL or Descriptions
# AltName	SL9C2_HUMAN	Na(+)/H(+) exchanger 11
# AltName	SL9C2_HUMAN	Solute carrier family 9 member 11
# AltName	SL9C2_HUMAN	Solute carrier family 9 member C2
# DOMAIN	SL9C2_HUMAN	Contains an ion transport-like region is related to the membrane segments of voltage-gated ion channels. {ECO 0000250}. 
# Ensembl	ENST00000367714	ENSP00000356687; ENSG00000162753
# FUNCTION	SL9C2_HUMAN	Involved in pH regulation. {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	SL9C2_HUMAN	GO 0015385 sodium proton antiporter activity; IBA GO_Central.
# GO_function	SL9C2_HUMAN	GO 0015386 potassium proton antiporter activity; IBA GO_Central.
# GO_process	GO:0051453	regulation of intracellular pH; IBA:GO_Central.
# GO_process	GO:0071805	potassium ion transmembrane transport; IBA:GO_Central.
# GO_process	GO:0098719	sodium ion import across plasma membrane; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.350	-; 1.
# Gene3D	2.60.120.10	-; 1.
# Genevisible	Q5TAH2	HS
# HGNC	HGNC:28664	SLC9C2
# InterPro	IPR000595	cNMP-bd_dom
# InterPro	IPR006153	Cation/H_exchanger
# InterPro	IPR014710	RmlC-like_jellyroll
# InterPro	IPR018422	Cation/H_exchanger_CPA1
# InterPro	IPR018490	cNMP-bd-like
# InterPro	IPR027359	Channel_four-helix_dom
# KEGG_Brite	ko02001	Solute carrier family
# Organism	SL9C2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10110	PTHR10110; 2
# PROSITE	PS50042	CNMP_BINDING_3
# Pfam	PF00027	cNMP_binding
# Pfam	PF00999	Na_H_Exchanger
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	SL9C2_HUMAN	Sodium/hydrogen exchanger 11
# RefSeq	NP_848622	NM_178527.3
# SIMILARITY	Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. {ECO	0000305}. 
# SIMILARITY	Contains 1 cyclic nucleotide-binding domain. {ECO:0000255|PROSITE-ProRule	PRU00060}.
# SUBCELLULAR LOCATION	SL9C2_HUMAN	Membrane; Multi-pass membrane protein. 
# SUPFAM	SSF51206	SSF51206
# TCDB	2.A.36.7:the monovalent cation	proton antiporter-1 (cpa1) family
# UCSC	uc001giz	human
# eggNOG	COG0025	LUCA
# eggNOG	KOG0100	Eukaryota
BLAST	swissprot:SL9C2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SL9C2_HUMAN
COXPRESdb	284525	http://coxpresdb.jp/data/gene/284525.shtml
CleanEx	HS_SLC9A11	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC9A11
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AL139142	http://www.ebi.ac.uk/ena/data/view/AL139142
EMBL	BC042592	http://www.ebi.ac.uk/ena/data/view/BC042592
Ensembl	ENST00000367714	http://www.ensembl.org/id/ENST00000367714
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015385
GO_function	GO:0015386	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015386
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GO_process	GO:0098719	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098719
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
Gene3D	2.60.120.10	http://www.cathdb.info/version/latest/superfamily/2.60.120.10
GeneCards	SLC9C2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC9C2
GeneID	284525	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=284525
GeneTree	ENSGT00530000063840	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063840
HGNC	HGNC:28664	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:28664
HOGENOM	HOG000154241	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000154241&db=HOGENOM6
HOVERGEN	HBG102046	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG102046&db=HOVERGEN
HPA	HPA059122	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA059122
InParanoid	Q5TAH2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q5TAH2
InterPro	IPR000595	http://www.ebi.ac.uk/interpro/entry/IPR000595
InterPro	IPR006153	http://www.ebi.ac.uk/interpro/entry/IPR006153
InterPro	IPR014710	http://www.ebi.ac.uk/interpro/entry/IPR014710
InterPro	IPR018422	http://www.ebi.ac.uk/interpro/entry/IPR018422
InterPro	IPR018490	http://www.ebi.ac.uk/interpro/entry/IPR018490
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
Jabion	284525	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=284525
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:284525	http://www.genome.jp/dbget-bin/www_bget?hsa:284525
KEGG_Orthology	KO:K14726	http://www.genome.jp/dbget-bin/www_bget?KO:K14726
OMA	TPDKYLH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TPDKYLH
OrthoDB	EOG091G031U	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G031U
PANTHER	PTHR10110	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10110
PROSITE	PS50042	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50042
PSORT	swissprot:SL9C2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SL9C2_HUMAN
PSORT-B	swissprot:SL9C2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SL9C2_HUMAN
PSORT2	swissprot:SL9C2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SL9C2_HUMAN
Pfam	PF00027	http://pfam.xfam.org/family/PF00027
Pfam	PF00999	http://pfam.xfam.org/family/PF00999
PharmGKB	PA134865165	http://www.pharmgkb.org/do/serve?objId=PA134865165&objCls=Gene
Phobius	swissprot:SL9C2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SL9C2_HUMAN
PhylomeDB	Q5TAH2	http://phylomedb.org/?seqid=Q5TAH2
ProteinModelPortal	Q5TAH2	http://www.proteinmodelportal.org/query/uniprot/Q5TAH2
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_848622	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_848622
SMR	Q5TAH2	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q5TAH2
STRING	9606.ENSP00000356687	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000356687&targetmode=cogs
SUPFAM	SSF51206	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51206
TCDB	2.A.36.7	http://www.tcdb.org/search/result.php?tc=2.A.36.7
UCSC	uc001giz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001giz&org=rat
UniGene	Hs.494981	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.494981
UniProtKB	SL9C2_HUMAN	http://www.uniprot.org/uniprot/SL9C2_HUMAN
UniProtKB-AC	Q5TAH2	http://www.uniprot.org/uniprot/Q5TAH2
charge	swissprot:SL9C2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SL9C2_HUMAN
eggNOG	COG0025	http://eggnogapi.embl.de/nog_data/html/tree/COG0025
eggNOG	KOG0100	http://eggnogapi.embl.de/nog_data/html/tree/KOG0100
epestfind	swissprot:SL9C2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SL9C2_HUMAN
garnier	swissprot:SL9C2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SL9C2_HUMAN
helixturnhelix	swissprot:SL9C2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SL9C2_HUMAN
hmoment	swissprot:SL9C2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SL9C2_HUMAN
iep	swissprot:SL9C2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SL9C2_HUMAN
inforesidue	swissprot:SL9C2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SL9C2_HUMAN
neXtProt	NX_Q5TAH2	http://www.nextprot.org/db/entry/NX_Q5TAH2
octanol	swissprot:SL9C2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SL9C2_HUMAN
pepcoil	swissprot:SL9C2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SL9C2_HUMAN
pepdigest	swissprot:SL9C2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SL9C2_HUMAN
pepinfo	swissprot:SL9C2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SL9C2_HUMAN
pepnet	swissprot:SL9C2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SL9C2_HUMAN
pepstats	swissprot:SL9C2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SL9C2_HUMAN
pepwheel	swissprot:SL9C2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SL9C2_HUMAN
pepwindow	swissprot:SL9C2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SL9C2_HUMAN
sigcleave	swissprot:SL9C2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SL9C2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=37; Comment=Additional isoforms seem to exist. Exons 8A, 21, 22, 31, 32, 33, 40B, 43A, 41A and 45 are alternatively spliced in a variety of combinations. Experimental confirmation may be lacking for some isoforms.; Name=1; Synonyms=HFCC, Fibroblast; IsoId=Q13936-1; Sequence=Displayed; Name=2; IsoId=Q13936-2; Sequence=VSP_000894; Name=3; IsoId=Q13936-3; Sequence=VSP_000886; Note=Contains exon 8a.; Name=4; IsoId=Q13936-4; Sequence=VSP_000887; Note=Lacks exon 21.; Name=5; IsoId=Q13936-5; Sequence=VSP_000888; Note=Lacks exon 22.; Name=6; IsoId=Q13936-6; Sequence=VSP_000889; Note=Lacks exon 31.; Name=7; IsoId=Q13936-7; Sequence=VSP_000890; Note=Lacks exon 32.; Name=8; IsoId=Q13936-8; Sequence=VSP_000891; Note=Lacks exon 33.; Name=9; IsoId=Q13936-9; Sequence=VSP_000892; Note=Contains exon 40B and 43A.; Name=10; IsoId=Q13936-10; Sequence=VSP_000893; Note=Contains exon 41A.; Name=11; Synonyms=Alpha-1C.90; IsoId=Q13936-11; Sequence=VSP_000895; Note=Lacks exon 45.; Name=12; Synonyms=Alpha-1C.70; IsoId=Q13936-12; Sequence=VSP_000888, VSP_000889, VSP_000895; Name=13; Synonyms=Alpha-1C.127; IsoId=Q13936-13; Sequence=VSP_000888, VSP_000890, VSP_000893, VSP_000895; Name=14; Synonyms=Alpha-1C.126; IsoId=Q13936-14; Sequence=VSP_000888, VSP_000889, VSP_022504, VSP_000893, VSP_000895; Name=15; Synonyms=Alpha-1C.125; IsoId=Q13936-15; Sequence=VSP_000888, VSP_000889, VSP_022503, VSP_000893, VSP_000895; Name=16; IsoId=Q13936-16; Sequence=VSP_000885, VSP_000886, VSP_000888, VSP_000890; Name=17; IsoId=Q13936-17; Sequence=VSP_000885, VSP_000886, VSP_000888, VSP_000890, VSP_000895; Name=18; Synonyms=HHT-1; IsoId=Q13936-18; Sequence=VSP_000885, VSP_000886, VSP_000888, VSP_000890, VSP_000894; Name=19; Synonyms=Alpha-1C.76; IsoId=Q13936-19; Sequence=VSP_000887, VSP_000889, VSP_000891, VSP_000895; Name=20; Synonyms=Alpha-1C.77; IsoId=Q13936-20; Sequence=VSP_000887, VSP_000889, VSP_000895; Note=Predominant isoform in atherosclerotic vascular smooth muscle cells.; Name=21; Synonyms=Alpha-1C.69; IsoId=Q13936-21; Sequence=VSP_000887, VSP_000890, VSP_000895; Name=22; Synonyms=Alpha-1C.78; IsoId=Q13936-22; Sequence=VSP_000888, VSP_000890, VSP_000895; Name=23; Synonyms=Alpha-1C.105; IsoId=Q13936-23; Sequence=VSP_000886, VSP_000887, VSP_000889, VSP_000895; Name=24; Synonyms=Alpha-1C.71; IsoId=Q13936-24; Sequence=VSP_000888, VSP_000889, VSP_000893, VSP_000895; Name=25; Synonyms=Alpha-1C.73; IsoId=Q13936-25; Sequence=VSP_000888, VSP_000889, VSP_000891, VSP_000893, VSP_000895; Name=26; Synonyms=Alpha-1C.86; IsoId=Q13936-26; Sequence=VSP_000887, VSP_000889, VSP_000892, VSP_000895; Note=Not inhibited by calcium. Ref.3 (CAA84348) sequence is in conflict in position: 1573	A->T. {ECO:0000305}; Name=27; Synonyms=Alpha-1C.72; IsoId=Q13936-27; Sequence=VSP_000887, VSP_000889, VSP_000893, VSP_000895; Name=28; IsoId=Q13936-28; Sequence=VSP_000885, VSP_000886, VSP_000888, VSP_000889, VSP_000891, VSP_000894; Name=29; Synonyms=Alpha-1C.74; IsoId=Q13936-29; Sequence=VSP_000887, VSP_000889, VSP_000891, VSP_000893, VSP_000895; Name=30; Synonyms=Alpha-1C.87; IsoId=Q13936-30; Sequence=VSP_000889, VSP_000895; Name=31; Synonyms=Alpha-1C.88; IsoId=Q13936-31; Sequence=VSP_000888, VSP_000895; Name=32; Synonyms=Alpha-1C.89; IsoId=Q13936-32; Sequence=VSP_000887, VSP_000891, VSP_000895; Name=33; Synonyms=Alpha-1C.85; IsoId=Q13936-33; Sequence=VSP_000887, VSP_000889; Name=34; Synonyms=Alpha-1C,long-NT; IsoId=Q13936-34; Sequence=VSP_035146; Note=Enhanced by PKC activator.; Name=35; IsoId=Q13936-35; Sequence=VSP_035877, VSP_000888, VSP_000890, VSP_000895; Name=36; IsoId=Q13936-36; Sequence=VSP_000886, VSP_000888, VSP_000890; Note=Gene prediction based on EST data.; Name=37; IsoId=Q13936-37; Sequence=VSP_000886, VSP_000888, VSP_000890, VSP_000895; Note=Gene prediction based on EST data.; 
# AltName	CAC1C_HUMAN	Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle
# AltName	CAC1C_HUMAN	Voltage-gated calcium channel subunit alpha Cav1.2
# BioGrid	107229	14
# CCDS	CCDS44787	-. [Q13936-23]
# CCDS	CCDS44788	-. [Q13936-11]
# CCDS	CCDS44789	-. [Q13936-30]
# CCDS	CCDS44790	-. [Q13936-31]
# CCDS	CCDS44791	-. [Q13936-22]
# CCDS	CCDS44792	-. [Q13936-14]
# CCDS	CCDS44793	-. [Q13936-24]
# CCDS	CCDS44794	-. [Q13936-12]
# CCDS	CCDS44795	-. [Q13936-25]
# CCDS	CCDS44796	-. [Q13936-15]
# CCDS	CCDS44797	-. [Q13936-32]
# CCDS	CCDS44798	-. [Q13936-21]
# CCDS	CCDS44799	-. [Q13936-27]
# CCDS	CCDS44800	-. [Q13936-20]
# CCDS	CCDS44801	-. [Q13936-29]
# CCDS	CCDS53733	-. [Q13936-36]
# CCDS	CCDS53734	-. [Q13936-37]
# CCDS	CCDS53735	-. [Q13936-13]
# CCDS	CCDS53736	-. [Q13936-33]
# ChiTaRS	CACNA1C	human
# DISEASE	CAC1C_HUMAN	Brugada syndrome 3 (BRGDA3) [MIM 611875]  A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset. {ECO 0000269|PubMed 17224476}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CAC1C_HUMAN	Timothy syndrome (TS) [MIM 601005]  Disorder characterized by multiorgan dysfunction including lethal arrhythmias, webbing of fingers and toes, congenital heart disease, immune deficiency, intermittent hypoglycemia, cognitive abnormalities and autism. {ECO 0000269|PubMed 15454078, ECO 0000269|PubMed 15863612, ECO 0000269|PubMed 24728418, ECO 0000269|PubMed 25260352, ECO 0000269|PubMed 25633834, ECO 0000269|PubMed 26253506}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	CAC1C_HUMAN	Binding of intracellular calcium through the EF-hand motif inhibits the opening of the channel. {ECO 0000250|UniProtKB P15381}. 
# DOMAIN	CAC1C_HUMAN	Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position. 
# DrugBank	DB00270	Isradipine
# DrugBank	DB00308	Ibutilide
# DrugBank	DB00381	Amlodipine
# DrugBank	DB00393	Nimodipine
# DrugBank	DB00401	Nisoldipine
# DrugBank	DB00421	Spironolactone
# DrugBank	DB00568	Cinnarizine
# DrugBank	DB00622	Nicardipine
# DrugBank	DB00653	Magnesium Sulfate
# DrugBank	DB00661	Verapamil
# DrugBank	DB00898	Ethanol
# DrugBank	DB01023	Felodipine
# DrugBank	DB01054	Nitrendipine
# DrugBank	DB01115	Nifedipine
# DrugBank	DB04855	Dronedarone
# DrugBank	DB04920	Clevidipine
# DrugBank	DB06712	Nilvadipine
# DrugBank	DB06751	Drotaverine
# Ensembl	ENST00000344100	ENSP00000341092; ENSG00000151067. [Q13936-14]
# Ensembl	ENST00000347598	ENSP00000266376; ENSG00000151067. [Q13936-11]
# Ensembl	ENST00000399591	ENSP00000382500; ENSG00000151067. [Q13936-29]
# Ensembl	ENST00000399595	ENSP00000382504; ENSG00000151067. [Q13936-25]
# Ensembl	ENST00000399597	ENSP00000382506; ENSG00000151067. [Q13936-22]
# Ensembl	ENST00000399601	ENSP00000382510; ENSG00000151067. [Q13936-20]
# Ensembl	ENST00000399603	ENSP00000382512; ENSG00000151067. [Q13936-37]
# Ensembl	ENST00000399606	ENSP00000382515; ENSG00000151067. [Q13936-30]
# Ensembl	ENST00000399621	ENSP00000382530; ENSG00000151067. [Q13936-24]
# Ensembl	ENST00000399629	ENSP00000382537; ENSG00000151067. [Q13936-32]
# Ensembl	ENST00000399637	ENSP00000382546; ENSG00000151067. [Q13936-27]
# Ensembl	ENST00000399638	ENSP00000382547; ENSG00000151067. [Q13936-31]
# Ensembl	ENST00000399641	ENSP00000382549; ENSG00000151067. [Q13936-23]
# Ensembl	ENST00000399644	ENSP00000382552; ENSG00000151067. [Q13936-21]
# Ensembl	ENST00000399649	ENSP00000382557; ENSG00000151067. [Q13936-15]
# Ensembl	ENST00000399655	ENSP00000382563; ENSG00000151067. [Q13936-12]
# Ensembl	ENST00000402845	ENSP00000385724; ENSG00000151067. [Q13936-13]
# ExpressionAtlas	Q13936	baseline and differential
# FUNCTION	CAC1C_HUMAN	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function. {ECO 0000269|PubMed 12176756, ECO 0000269|PubMed 17071743, ECO 0000269|PubMed 7737988, ECO 0000269|PubMed 8392192, ECO 0000269|PubMed 9013606, ECO 0000269|PubMed 9607315}. 
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005891	voltage-gated calcium channel complex; IDA:UniProtKB.
# GO_component	GO:0014069	postsynaptic density; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IDA:UniProtKB.
# GO_component	GO:0030018	Z disc; ISS:BHF-UCL.
# GO_component	GO:1990454	L-type voltage-gated calcium channel complex; IDA:BHF-UCL.
# GO_function	GO:0005245	voltage-gated calcium channel activity; IDA:UniProtKB.
# GO_function	GO:0005516	calmodulin binding; IPI:UniProtKB.
# GO_function	GO:0008331	high voltage-gated calcium channel activity; IDA:BHF-UCL.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_function	GO:0051393	alpha-actinin binding; IPI:BHF-UCL.
# GO_function	GO:0086007	voltage-gated calcium channel activity involved in cardiac muscle cell action potential; IMP:BHF-UCL.
# GO_function	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential; IMP:BHF-UCL.
# GO_process	GO:0002520	immune system development; IMP:BHF-UCL.
# GO_process	GO:0007204	positive regulation of cytosolic calcium ion concentration; IDA:UniProtKB.
# GO_process	GO:0007507	heart development; IMP:BHF-UCL.
# GO_process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; TAS:BHF-UCL.
# GO_process	GO:0035115	embryonic forelimb morphogenesis; IMP:BHF-UCL.
# GO_process	GO:0035585	calcium-mediated signaling using extracellular calcium source; TAS:BHF-UCL.
# GO_process	GO:0043010	camera-type eye development; IMP:BHF-UCL.
# GO_process	GO:0050796	regulation of insulin secretion; TAS:Reactome.
# GO_process	GO:0060402	calcium ion transport into cytosol; TAS:BHF-UCL.
# GO_process	GO:0061337	cardiac conduction; IMP:UniProtKB.
# GO_process	GO:0061577	calcium ion transmembrane transport via high voltage-gated calcium channel; IDA:BHF-UCL.
# GO_process	GO:0070588	calcium ion transmembrane transport; IMP:UniProtKB.
# GO_process	GO:0086002	cardiac muscle cell action potential involved in contraction; IMP:BHF-UCL.
# GO_process	GO:0086012	membrane depolarization during cardiac muscle cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086045	membrane depolarization during AV node cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086064	cell communication by electrical coupling involved in cardiac conduction; TAS:BHF-UCL.
# GO_process	GO:0086091	regulation of heart rate by cardiac conduction; IMP:BHF-UCL.
# GO_process	GO:0098911	regulation of ventricular cardiac muscle cell action potential; IMP:BHF-UCL.
# GO_process	GO:0098912	membrane depolarization during atrial cardiac muscle cell action potential; IMP:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008092	cytoskeletal protein binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.350	-; 6.
# Genevisible	Q13936	HS
# HGNC	HGNC:1390	CACNA1C
# INTERACTION	CAC1C_HUMAN	Q9NZU7 CABP1; NbExp=4; IntAct=EBI-1038838, EBI-907894; P62158 CALM3; NbExp=12; IntAct=EBI-1038838, EBI-397435; 
# IntAct	Q13936	4
# InterPro	IPR002077	VDCCAlpha1
# InterPro	IPR005446	VDCC_L_a1su
# InterPro	IPR005451	VDCC_L_a1csu
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR014873	VDCC_a1su_IQ
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR031649	GPHH_dom
# InterPro	IPR031688	CAC1F_C
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00720	[Cardiovascular disease] Jervell and Lange-Nielsen syndrome (JLNS)
# KEGG_Disease	H00728	[Cardiovascular disease] Brugada syndrome (BRS)
# KEGG_Pathway	ko04010	MAPK signaling pathway
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko04270	Vascular smooth muscle contraction
# KEGG_Pathway	ko04713	Circadian entrainment
# KEGG_Pathway	ko04720	Long-term potentiation
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04724	Glutamatergic synapse
# KEGG_Pathway	ko04725	Cholinergic synapse
# KEGG_Pathway	ko04726	Serotonergic synapse
# KEGG_Pathway	ko04727	GABAergic synapse
# KEGG_Pathway	ko04728	Dopaminergic synapse
# KEGG_Pathway	ko04912	GnRH signaling pathway
# KEGG_Pathway	ko04930	Type II diabetes mellitus
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05031	Amphetamine addiction
# KEGG_Pathway	ko05410	Hypertrophic cardiomyopathy (HCM)
# KEGG_Pathway	ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
# KEGG_Pathway	ko05414	Dilated cardiomyopathy
# MIM	114205	gene
# MIM	601005	phenotype
# MIM	611875	phenotype
# Organism	CAC1C_HUMAN	Homo sapiens (Human)
# Orphanet	130	Brugada syndrome
# Orphanet	65283	Timothy syndrome
# PANTHER	PTHR10037:SF188	PTHR10037:SF188; 3
# PDB	1T0J	X-ray; 2.00 A; C=428-445
# PDB	2BE6	X-ray; 2.00 A; D/E/F=1659-1692
# PDB	2F3Y	X-ray; 1.45 A; B=1665-1685
# PDB	2F3Z	X-ray; 1.60 A; B=1665-1685
# PDB	2LQC	NMR; -; B=47-68
# PDB	3G43	X-ray; 2.10 A; E/F=1609-1682
# PDB	3OXQ	X-ray; 2.55 A; E/F=1609-1685
# PIR	A23660	A23660
# PIR	A44363	A44363
# PIR	A45290	A45290
# PIR	B23660	B23660
# PIR	C23660	C23660
# PIR	I54168	I54168
# PRINTS	PR00167	CACHANNEL
# PRINTS	PR01630	LVDCCALPHA1
# PRINTS	PR01635	LVDCCALPHA1C
# PTM	CAC1C_HUMAN	Phosphorylation by PKA activates the channel. {ECO 0000250|UniProtKB P15381}. 
# Pfam	PF00520	Ion_trans; 5
# Pfam	PF08763	Ca_chan_IQ
# Pfam	PF16885	CAC1F_C; 2
# Pfam	PF16905	GPHH
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-400042	Adrenaline,noradrenaline inhibits insulin secretion
# Reactome	R-HSA-419037	NCAM1 interactions
# Reactome	R-HSA-422356	Regulation of insulin secretion
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# Reactome	R-HSA-5576893	Phase 2 - plateau phase
# Reactome	R-HSA-5576894	Phase 1 - inactivation of fast Na+ channels
# RecName	CAC1C_HUMAN	Voltage-dependent L-type calcium channel subunit alpha-1C
# RefSeq	NP_000710	NM_000719.6. [Q13936-12]
# RefSeq	NP_001123299	NM_001129827.1. [Q13936-11]
# RefSeq	NP_001123301	NM_001129829.1. [Q13936-14]
# RefSeq	NP_001123302	NM_001129830.2
# RefSeq	NP_001123303	NM_001129831.1. [Q13936-31]
# RefSeq	NP_001123304	NM_001129832.1. [Q13936-30]
# RefSeq	NP_001123305	NM_001129833.1. [Q13936-13]
# RefSeq	NP_001123306	NM_001129834.1. [Q13936-24]
# RefSeq	NP_001123307	NM_001129835.1. [Q13936-27]
# RefSeq	NP_001123308	NM_001129836.1. [Q13936-32]
# RefSeq	NP_001123309	NM_001129837.1. [Q13936-25]
# RefSeq	NP_001123310	NM_001129838.1. [Q13936-29]
# RefSeq	NP_001123311	NM_001129839.1. [Q13936-15]
# RefSeq	NP_001123312	NM_001129840.1. [Q13936-23]
# RefSeq	NP_001123313	NM_001129841.1. [Q13936-21]
# RefSeq	NP_001123314	NM_001129842.1. [Q13936-22]
# RefSeq	NP_001123315	NM_001129843.1. [Q13936-20]
# RefSeq	NP_001123316	NM_001129844.1. [Q13936-35]
# RefSeq	NP_001123318	NM_001129846.1. [Q13936-19]
# RefSeq	NP_001161095	NM_001167623.1. [Q13936-37]
# RefSeq	NP_001161096	NM_001167624.2
# RefSeq	NP_001161097	NM_001167625.1
# RefSeq	NP_955630	NM_199460.3
# SEQUENCE CAUTION	Sequence=AAA02500.2; Type=Frameshift; Positions=1844; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily. {ECO	0000305}. 
# SMART	SM01062	Ca_chan_IQ
# SUBCELLULAR LOCATION	CAC1C_HUMAN	Membrane {ECO 0000250|UniProtKB P15381}; Multi-pass membrane protein {ECO 0000250|UniProtKB P15381}. Cell membrane {ECO 0000250|UniProtKB P15381}. Note=The interaction between RRAD and CACNB2 regulates its trafficking to the cell membrane. {ECO 0000250|UniProtKB P15381}. 
# SUBUNIT	CAC1C_HUMAN	Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1 1 1 1 ratio. The channel activity is directed by the pore- forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with CACNA2D4. Interacts (via the N-terminus and the C- terminal C and IQ motifs) with CABP1. The binding via the C motif is calcium independent whereas the binding via IQ requires the presence of calcium and is mutually exclusive with calmodulin binding. The binding to the cytoplasmic N-terminal domain is calcium independent but is essential for the channel modulation. Interacts (via C-terminal CDB motif) with CABP5; in a calcium- dependent manner (By similarity). Interacts with CIB1; the interaction increases upon cardiomyocytes hypertrophy (By similarity). {ECO 0000250, ECO 0000269|PubMed 12181424, ECO 0000269|PubMed 15140941, ECO 0000269|PubMed 15141227, ECO 0000269|PubMed 15980432}. 
# TCDB	1.A.1.11	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	CAC1C_HUMAN	Expressed in brain, heart, jejunum, ovary, pancreatic beta-cells and vascular smooth muscle. Overall expression is reduced in atherosclerotic vascular smooth muscle. {ECO 0000269|PubMed 12176756, ECO 0000269|PubMed 17071743, ECO 0000269|PubMed 8392192}. 
# UCSC	uc001qjz	human. [Q13936-1]
# eggNOG	ENOG410XNP6	LUCA
# eggNOG	KOG2301	Eukaryota
BLAST	swissprot:CAC1C_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CAC1C_HUMAN
BioCyc	ZFISH:ENSG00000151067-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000151067-MONOMER
COXPRESdb	775	http://coxpresdb.jp/data/gene/775.shtml
DIP	DIP-29589N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29589N
DOI	10.1006/geno.1994.1347	http://dx.doi.org/10.1006/geno.1994.1347
DOI	10.1016/0888-7543(91)90471-P	http://dx.doi.org/10.1016/0888-7543(91)90471-P
DOI	10.1016/S0014-5793(98)00425-6	http://dx.doi.org/10.1016/S0014-5793(98)00425-6
DOI	10.1016/S0888-7543(05)80135-1	http://dx.doi.org/10.1016/S0888-7543(05)80135-1
DOI	10.1016/j.cell.2004.09.011	http://dx.doi.org/10.1016/j.cell.2004.09.011
DOI	10.1016/j.hrthm.2014.09.051	http://dx.doi.org/10.1016/j.hrthm.2014.09.051
DOI	10.1016/j.yjmcc.2015.01.002	http://dx.doi.org/10.1016/j.yjmcc.2015.01.002
DOI	10.1038/nature02588	http://dx.doi.org/10.1038/nature02588
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1038/nature09639	http://dx.doi.org/10.1038/nature09639
DOI	10.1073/pnas.0502506102	http://dx.doi.org/10.1073/pnas.0502506102
DOI	10.1073/pnas.0606539103	http://dx.doi.org/10.1073/pnas.0606539103
DOI	10.1073/pnas.89.10.4628	http://dx.doi.org/10.1073/pnas.89.10.4628
DOI	10.1073/pnas.90.13.6228	http://dx.doi.org/10.1073/pnas.90.13.6228
DOI	10.1074/jbc.270.18.10540	http://dx.doi.org/10.1074/jbc.270.18.10540
DOI	10.1074/jbc.272.6.3560	http://dx.doi.org/10.1074/jbc.272.6.3560
DOI	10.1074/jbc.C100642200	http://dx.doi.org/10.1074/jbc.C100642200
DOI	10.1074/jbc.M504167200	http://dx.doi.org/10.1074/jbc.M504167200
DOI	10.1093/europace/euu063	http://dx.doi.org/10.1093/europace/euu063
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/chd.12371	http://dx.doi.org/10.1111/chd.12371
DOI	10.1124/mol.62.3.485	http://dx.doi.org/10.1124/mol.62.3.485
DOI	10.1152/ajpcell.00140.2002	http://dx.doi.org/10.1152/ajpcell.00140.2002
DOI	10.1161/CIRCEP.115.002745	http://dx.doi.org/10.1161/CIRCEP.115.002745
DOI	10.1161/CIRCULATIONAHA.106.668392	http://dx.doi.org/10.1161/CIRCULATIONAHA.106.668392
DOI	10.1523/JNEUROSCI.5523-03.2004	http://dx.doi.org/10.1523/JNEUROSCI.5523-03.2004
DrugBank	DB00270	http://www.drugbank.ca/drugs/DB00270
DrugBank	DB00308	http://www.drugbank.ca/drugs/DB00308
DrugBank	DB00381	http://www.drugbank.ca/drugs/DB00381
DrugBank	DB00393	http://www.drugbank.ca/drugs/DB00393
DrugBank	DB00401	http://www.drugbank.ca/drugs/DB00401
DrugBank	DB00421	http://www.drugbank.ca/drugs/DB00421
DrugBank	DB00568	http://www.drugbank.ca/drugs/DB00568
DrugBank	DB00622	http://www.drugbank.ca/drugs/DB00622
DrugBank	DB00653	http://www.drugbank.ca/drugs/DB00653
DrugBank	DB00661	http://www.drugbank.ca/drugs/DB00661
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01023	http://www.drugbank.ca/drugs/DB01023
DrugBank	DB01054	http://www.drugbank.ca/drugs/DB01054
DrugBank	DB01115	http://www.drugbank.ca/drugs/DB01115
DrugBank	DB04855	http://www.drugbank.ca/drugs/DB04855
DrugBank	DB04920	http://www.drugbank.ca/drugs/DB04920
DrugBank	DB06712	http://www.drugbank.ca/drugs/DB06712
DrugBank	DB06751	http://www.drugbank.ca/drugs/DB06751
EMBL	AC005293	http://www.ebi.ac.uk/ena/data/view/AC005293
EMBL	AC005342	http://www.ebi.ac.uk/ena/data/view/AC005342
EMBL	AC005344	http://www.ebi.ac.uk/ena/data/view/AC005344
EMBL	AC005414	http://www.ebi.ac.uk/ena/data/view/AC005414
EMBL	AC005866	http://www.ebi.ac.uk/ena/data/view/AC005866
EMBL	AC006051	http://www.ebi.ac.uk/ena/data/view/AC006051
EMBL	AC007618	http://www.ebi.ac.uk/ena/data/view/AC007618
EMBL	AF465484	http://www.ebi.ac.uk/ena/data/view/AF465484
EMBL	AJ224873	http://www.ebi.ac.uk/ena/data/view/AJ224873
EMBL	AY604867	http://www.ebi.ac.uk/ena/data/view/AY604867
EMBL	AY830711	http://www.ebi.ac.uk/ena/data/view/AY830711
EMBL	AY830712	http://www.ebi.ac.uk/ena/data/view/AY830712
EMBL	AY830713	http://www.ebi.ac.uk/ena/data/view/AY830713
EMBL	BC146846	http://www.ebi.ac.uk/ena/data/view/BC146846
EMBL	L04568	http://www.ebi.ac.uk/ena/data/view/L04568
EMBL	L04569	http://www.ebi.ac.uk/ena/data/view/L04569
EMBL	L29529	http://www.ebi.ac.uk/ena/data/view/L29529
EMBL	L29530	http://www.ebi.ac.uk/ena/data/view/L29530
EMBL	L29531	http://www.ebi.ac.uk/ena/data/view/L29531
EMBL	L29532	http://www.ebi.ac.uk/ena/data/view/L29532
EMBL	L29533	http://www.ebi.ac.uk/ena/data/view/L29533
EMBL	L29534	http://www.ebi.ac.uk/ena/data/view/L29534
EMBL	L29535	http://www.ebi.ac.uk/ena/data/view/L29535
EMBL	L29536	http://www.ebi.ac.uk/ena/data/view/L29536
EMBL	L29537	http://www.ebi.ac.uk/ena/data/view/L29537
EMBL	L29538	http://www.ebi.ac.uk/ena/data/view/L29538
EMBL	L29539	http://www.ebi.ac.uk/ena/data/view/L29539
EMBL	M57971	http://www.ebi.ac.uk/ena/data/view/M57971
EMBL	M57972	http://www.ebi.ac.uk/ena/data/view/M57972
EMBL	M61130	http://www.ebi.ac.uk/ena/data/view/M61130
EMBL	M91370	http://www.ebi.ac.uk/ena/data/view/M91370
EMBL	M92269	http://www.ebi.ac.uk/ena/data/view/M92269
EMBL	M92270	http://www.ebi.ac.uk/ena/data/view/M92270
EMBL	M92271	http://www.ebi.ac.uk/ena/data/view/M92271
EMBL	M92272	http://www.ebi.ac.uk/ena/data/view/M92272
EMBL	M92273	http://www.ebi.ac.uk/ena/data/view/M92273
EMBL	M92274	http://www.ebi.ac.uk/ena/data/view/M92274
EMBL	M92275	http://www.ebi.ac.uk/ena/data/view/M92275
EMBL	Z26256	http://www.ebi.ac.uk/ena/data/view/Z26256
EMBL	Z26257	http://www.ebi.ac.uk/ena/data/view/Z26257
EMBL	Z26258	http://www.ebi.ac.uk/ena/data/view/Z26258
EMBL	Z26259	http://www.ebi.ac.uk/ena/data/view/Z26259
EMBL	Z26260	http://www.ebi.ac.uk/ena/data/view/Z26260
EMBL	Z26261	http://www.ebi.ac.uk/ena/data/view/Z26261
EMBL	Z26262	http://www.ebi.ac.uk/ena/data/view/Z26262
EMBL	Z26263	http://www.ebi.ac.uk/ena/data/view/Z26263
EMBL	Z26264	http://www.ebi.ac.uk/ena/data/view/Z26264
EMBL	Z26265	http://www.ebi.ac.uk/ena/data/view/Z26265
EMBL	Z26266	http://www.ebi.ac.uk/ena/data/view/Z26266
EMBL	Z26267	http://www.ebi.ac.uk/ena/data/view/Z26267
EMBL	Z26268	http://www.ebi.ac.uk/ena/data/view/Z26268
EMBL	Z26269	http://www.ebi.ac.uk/ena/data/view/Z26269
EMBL	Z26271	http://www.ebi.ac.uk/ena/data/view/Z26271
EMBL	Z26272	http://www.ebi.ac.uk/ena/data/view/Z26272
EMBL	Z26273	http://www.ebi.ac.uk/ena/data/view/Z26273
EMBL	Z26274	http://www.ebi.ac.uk/ena/data/view/Z26274
EMBL	Z26275	http://www.ebi.ac.uk/ena/data/view/Z26275
EMBL	Z26276	http://www.ebi.ac.uk/ena/data/view/Z26276
EMBL	Z26277	http://www.ebi.ac.uk/ena/data/view/Z26277
EMBL	Z26278	http://www.ebi.ac.uk/ena/data/view/Z26278
EMBL	Z26279	http://www.ebi.ac.uk/ena/data/view/Z26279
EMBL	Z26280	http://www.ebi.ac.uk/ena/data/view/Z26280
EMBL	Z26281	http://www.ebi.ac.uk/ena/data/view/Z26281
EMBL	Z26282	http://www.ebi.ac.uk/ena/data/view/Z26282
EMBL	Z26283	http://www.ebi.ac.uk/ena/data/view/Z26283
EMBL	Z26284	http://www.ebi.ac.uk/ena/data/view/Z26284
EMBL	Z26286	http://www.ebi.ac.uk/ena/data/view/Z26286
EMBL	Z26287	http://www.ebi.ac.uk/ena/data/view/Z26287
EMBL	Z26288	http://www.ebi.ac.uk/ena/data/view/Z26288
EMBL	Z26294	http://www.ebi.ac.uk/ena/data/view/Z26294
EMBL	Z26295	http://www.ebi.ac.uk/ena/data/view/Z26295
EMBL	Z26308	http://www.ebi.ac.uk/ena/data/view/Z26308
EMBL	Z34809	http://www.ebi.ac.uk/ena/data/view/Z34809
EMBL	Z34810	http://www.ebi.ac.uk/ena/data/view/Z34810
EMBL	Z34811	http://www.ebi.ac.uk/ena/data/view/Z34811
EMBL	Z34812	http://www.ebi.ac.uk/ena/data/view/Z34812
EMBL	Z34813	http://www.ebi.ac.uk/ena/data/view/Z34813
EMBL	Z34814	http://www.ebi.ac.uk/ena/data/view/Z34814
EMBL	Z34815	http://www.ebi.ac.uk/ena/data/view/Z34815
EMBL	Z34816	http://www.ebi.ac.uk/ena/data/view/Z34816
EMBL	Z34817	http://www.ebi.ac.uk/ena/data/view/Z34817
EMBL	Z34818	http://www.ebi.ac.uk/ena/data/view/Z34818
EMBL	Z34819	http://www.ebi.ac.uk/ena/data/view/Z34819
EMBL	Z34820	http://www.ebi.ac.uk/ena/data/view/Z34820
EMBL	Z34821	http://www.ebi.ac.uk/ena/data/view/Z34821
EMBL	Z34822	http://www.ebi.ac.uk/ena/data/view/Z34822
EMBL	Z74996	http://www.ebi.ac.uk/ena/data/view/Z74996
Ensembl	ENST00000344100	http://www.ensembl.org/id/ENST00000344100
Ensembl	ENST00000347598	http://www.ensembl.org/id/ENST00000347598
Ensembl	ENST00000399591	http://www.ensembl.org/id/ENST00000399591
Ensembl	ENST00000399595	http://www.ensembl.org/id/ENST00000399595
Ensembl	ENST00000399597	http://www.ensembl.org/id/ENST00000399597
Ensembl	ENST00000399601	http://www.ensembl.org/id/ENST00000399601
Ensembl	ENST00000399603	http://www.ensembl.org/id/ENST00000399603
Ensembl	ENST00000399606	http://www.ensembl.org/id/ENST00000399606
Ensembl	ENST00000399621	http://www.ensembl.org/id/ENST00000399621
Ensembl	ENST00000399629	http://www.ensembl.org/id/ENST00000399629
Ensembl	ENST00000399637	http://www.ensembl.org/id/ENST00000399637
Ensembl	ENST00000399638	http://www.ensembl.org/id/ENST00000399638
Ensembl	ENST00000399641	http://www.ensembl.org/id/ENST00000399641
Ensembl	ENST00000399644	http://www.ensembl.org/id/ENST00000399644
Ensembl	ENST00000399649	http://www.ensembl.org/id/ENST00000399649
Ensembl	ENST00000399655	http://www.ensembl.org/id/ENST00000399655
Ensembl	ENST00000402845	http://www.ensembl.org/id/ENST00000402845
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005891
GO_component	GO:0014069	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014069
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030018	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030018
GO_component	GO:1990454	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990454
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0005516	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005516
GO_function	GO:0008331	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008331
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_function	GO:0051393	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051393
GO_function	GO:0086007	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086007
GO_function	GO:0086056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086056
GO_process	GO:0002520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002520
GO_process	GO:0007204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007204
GO_process	GO:0007507	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007507
GO_process	GO:0010881	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010881
GO_process	GO:0035115	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035115
GO_process	GO:0035585	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035585
GO_process	GO:0043010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043010
GO_process	GO:0050796	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050796
GO_process	GO:0060402	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060402
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:0061577	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061577
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:0086002	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086002
GO_process	GO:0086012	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086012
GO_process	GO:0086045	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086045
GO_process	GO:0086064	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086064
GO_process	GO:0086091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086091
GO_process	GO:0098911	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098911
GO_process	GO:0098912	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098912
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	CACNA1C	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CACNA1C
GeneID	775	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=775
GeneTree	ENSGT00830000128247	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00830000128247
H-InvDB	HIX0010327	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0010327
HGNC	HGNC:1390	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1390
HOVERGEN	HBG050763	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050763&db=HOVERGEN
HPA	HPA039796	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA039796
InParanoid	Q13936	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q13936
IntAct	Q13936	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q13936*
InterPro	IPR002077	http://www.ebi.ac.uk/interpro/entry/IPR002077
InterPro	IPR005446	http://www.ebi.ac.uk/interpro/entry/IPR005446
InterPro	IPR005451	http://www.ebi.ac.uk/interpro/entry/IPR005451
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR014873	http://www.ebi.ac.uk/interpro/entry/IPR014873
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR031649	http://www.ebi.ac.uk/interpro/entry/IPR031649
InterPro	IPR031688	http://www.ebi.ac.uk/interpro/entry/IPR031688
Jabion	775	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=775
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00720	http://www.genome.jp/dbget-bin/www_bget?H00720
KEGG_Disease	H00728	http://www.genome.jp/dbget-bin/www_bget?H00728
KEGG_Gene	hsa:775	http://www.genome.jp/dbget-bin/www_bget?hsa:775
KEGG_Orthology	KO:K04850	http://www.genome.jp/dbget-bin/www_bget?KO:K04850
KEGG_Pathway	ko04010	http://www.genome.jp/kegg-bin/show_pathway?ko04010
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko04270	http://www.genome.jp/kegg-bin/show_pathway?ko04270
KEGG_Pathway	ko04713	http://www.genome.jp/kegg-bin/show_pathway?ko04713
KEGG_Pathway	ko04720	http://www.genome.jp/kegg-bin/show_pathway?ko04720
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
KEGG_Pathway	ko04725	http://www.genome.jp/kegg-bin/show_pathway?ko04725
KEGG_Pathway	ko04726	http://www.genome.jp/kegg-bin/show_pathway?ko04726
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
KEGG_Pathway	ko04728	http://www.genome.jp/kegg-bin/show_pathway?ko04728
KEGG_Pathway	ko04912	http://www.genome.jp/kegg-bin/show_pathway?ko04912
KEGG_Pathway	ko04930	http://www.genome.jp/kegg-bin/show_pathway?ko04930
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05031	http://www.genome.jp/kegg-bin/show_pathway?ko05031
KEGG_Pathway	ko05410	http://www.genome.jp/kegg-bin/show_pathway?ko05410
KEGG_Pathway	ko05412	http://www.genome.jp/kegg-bin/show_pathway?ko05412
KEGG_Pathway	ko05414	http://www.genome.jp/kegg-bin/show_pathway?ko05414
MIM	114205	http://www.ncbi.nlm.nih.gov/omim/114205
MIM	601005	http://www.ncbi.nlm.nih.gov/omim/601005
MIM	611875	http://www.ncbi.nlm.nih.gov/omim/611875
Orphanet	130	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=130
Orphanet	65283	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=65283
PANTHER	PTHR10037:SF188	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10037:SF188
PDB	1T0J	http://www.ebi.ac.uk/pdbe-srv/view/entry/1T0J
PDB	2BE6	http://www.ebi.ac.uk/pdbe-srv/view/entry/2BE6
PDB	2F3Y	http://www.ebi.ac.uk/pdbe-srv/view/entry/2F3Y
PDB	2F3Z	http://www.ebi.ac.uk/pdbe-srv/view/entry/2F3Z
PDB	2LQC	http://www.ebi.ac.uk/pdbe-srv/view/entry/2LQC
PDB	3G43	http://www.ebi.ac.uk/pdbe-srv/view/entry/3G43
PDB	3OXQ	http://www.ebi.ac.uk/pdbe-srv/view/entry/3OXQ
PDBsum	1T0J	http://www.ebi.ac.uk/pdbsum/1T0J
PDBsum	2BE6	http://www.ebi.ac.uk/pdbsum/2BE6
PDBsum	2F3Y	http://www.ebi.ac.uk/pdbsum/2F3Y
PDBsum	2F3Z	http://www.ebi.ac.uk/pdbsum/2F3Z
PDBsum	2LQC	http://www.ebi.ac.uk/pdbsum/2LQC
PDBsum	3G43	http://www.ebi.ac.uk/pdbsum/3G43
PDBsum	3OXQ	http://www.ebi.ac.uk/pdbsum/3OXQ
PRINTS	PR00167	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00167
PRINTS	PR01630	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01630
PRINTS	PR01635	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01635
PSORT	swissprot:CAC1C_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CAC1C_HUMAN
PSORT-B	swissprot:CAC1C_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CAC1C_HUMAN
PSORT2	swissprot:CAC1C_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CAC1C_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF08763	http://pfam.xfam.org/family/PF08763
Pfam	PF16885	http://pfam.xfam.org/family/PF16885
Pfam	PF16905	http://pfam.xfam.org/family/PF16905
PharmGKB	PA83	http://www.pharmgkb.org/do/serve?objId=PA83&objCls=Gene
Phobius	swissprot:CAC1C_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CAC1C_HUMAN
PhylomeDB	Q13936	http://phylomedb.org/?seqid=Q13936
ProteinModelPortal	Q13936	http://www.proteinmodelportal.org/query/uniprot/Q13936
PubMed	11741969	http://www.ncbi.nlm.nih.gov/pubmed/11741969
PubMed	12176756	http://www.ncbi.nlm.nih.gov/pubmed/12176756
PubMed	12181424	http://www.ncbi.nlm.nih.gov/pubmed/12181424
PubMed	1316612	http://www.ncbi.nlm.nih.gov/pubmed/1316612
PubMed	1335957	http://www.ncbi.nlm.nih.gov/pubmed/1335957
PubMed	15140941	http://www.ncbi.nlm.nih.gov/pubmed/15140941
PubMed	15141227	http://www.ncbi.nlm.nih.gov/pubmed/15141227
PubMed	15454078	http://www.ncbi.nlm.nih.gov/pubmed/15454078
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15863612	http://www.ncbi.nlm.nih.gov/pubmed/15863612
PubMed	15980432	http://www.ncbi.nlm.nih.gov/pubmed/15980432
PubMed	1653763	http://www.ncbi.nlm.nih.gov/pubmed/1653763
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	17071743	http://www.ncbi.nlm.nih.gov/pubmed/17071743
PubMed	17224476	http://www.ncbi.nlm.nih.gov/pubmed/17224476
PubMed	21248752	http://www.ncbi.nlm.nih.gov/pubmed/21248752
PubMed	2173707	http://www.ncbi.nlm.nih.gov/pubmed/2173707
PubMed	24728418	http://www.ncbi.nlm.nih.gov/pubmed/24728418
PubMed	25260352	http://www.ncbi.nlm.nih.gov/pubmed/25260352
PubMed	25633834	http://www.ncbi.nlm.nih.gov/pubmed/25633834
PubMed	26253506	http://www.ncbi.nlm.nih.gov/pubmed/26253506
PubMed	27218670	http://www.ncbi.nlm.nih.gov/pubmed/27218670
PubMed	7737988	http://www.ncbi.nlm.nih.gov/pubmed/7737988
PubMed	7959794	http://www.ncbi.nlm.nih.gov/pubmed/7959794
PubMed	8099908	http://www.ncbi.nlm.nih.gov/pubmed/8099908
PubMed	8392192	http://www.ncbi.nlm.nih.gov/pubmed/8392192
PubMed	9013606	http://www.ncbi.nlm.nih.gov/pubmed/9013606
PubMed	9087614	http://www.ncbi.nlm.nih.gov/pubmed/9087614
PubMed	9607315	http://www.ncbi.nlm.nih.gov/pubmed/9607315
Reactome	R-HSA-400042	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-400042
Reactome	R-HSA-419037	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-419037
Reactome	R-HSA-422356	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-422356
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
Reactome	R-HSA-5576893	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576893
Reactome	R-HSA-5576894	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576894
RefSeq	NP_000710	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000710
RefSeq	NP_001123299	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001123299
RefSeq	NP_001123301	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001123301
RefSeq	NP_001123302	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001123302
RefSeq	NP_001123303	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001123303
RefSeq	NP_001123304	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001123304
RefSeq	NP_001123305	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001123305
RefSeq	NP_001123306	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001123306
RefSeq	NP_001123307	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001123307
RefSeq	NP_001123308	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001123308
RefSeq	NP_001123309	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001123309
RefSeq	NP_001123310	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001123310
RefSeq	NP_001123311	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001123311
RefSeq	NP_001123312	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001123312
RefSeq	NP_001123313	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001123313
RefSeq	NP_001123314	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001123314
RefSeq	NP_001123315	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001123315
RefSeq	NP_001123316	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001123316
RefSeq	NP_001123318	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001123318
RefSeq	NP_001161095	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001161095
RefSeq	NP_001161096	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001161096
RefSeq	NP_001161097	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001161097
RefSeq	NP_955630	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_955630
SMART	SM01062	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01062
SMR	Q13936	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q13936
STRING	9606.ENSP00000266376	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000266376&targetmode=cogs
TCDB	1.A.1.11	http://www.tcdb.org/search/result.php?tc=1.A.1.11
UCSC	uc001qjz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001qjz&org=rat
UniGene	Hs.118262	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.118262
UniGene	Hs.690010	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.690010
UniProtKB	CAC1C_HUMAN	http://www.uniprot.org/uniprot/CAC1C_HUMAN
UniProtKB-AC	Q13936	http://www.uniprot.org/uniprot/Q13936
charge	swissprot:CAC1C_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CAC1C_HUMAN
eggNOG	ENOG410XNP6	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNP6
eggNOG	KOG2301	http://eggnogapi.embl.de/nog_data/html/tree/KOG2301
epestfind	swissprot:CAC1C_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CAC1C_HUMAN
garnier	swissprot:CAC1C_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CAC1C_HUMAN
helixturnhelix	swissprot:CAC1C_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CAC1C_HUMAN
hmoment	swissprot:CAC1C_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CAC1C_HUMAN
iep	swissprot:CAC1C_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CAC1C_HUMAN
inforesidue	swissprot:CAC1C_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CAC1C_HUMAN
neXtProt	NX_Q13936	http://www.nextprot.org/db/entry/NX_Q13936
octanol	swissprot:CAC1C_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CAC1C_HUMAN
pepcoil	swissprot:CAC1C_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CAC1C_HUMAN
pepdigest	swissprot:CAC1C_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CAC1C_HUMAN
pepinfo	swissprot:CAC1C_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CAC1C_HUMAN
pepnet	swissprot:CAC1C_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CAC1C_HUMAN
pepstats	swissprot:CAC1C_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CAC1C_HUMAN
pepwheel	swissprot:CAC1C_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CAC1C_HUMAN
pepwindow	swissprot:CAC1C_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CAC1C_HUMAN
sigcleave	swissprot:CAC1C_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CAC1C_HUMAN
## Database	ID	URL or Descriptions
# AltName	TOM20_HUMAN	Mitochondrial 20 kDa outer membrane protein
# AltName	TOM20_HUMAN	Outer mitochondrial membrane receptor Tom20
# BioGrid	115144	45
# ChiTaRS	TOMM20	human
# Ensembl	ENST00000366607	ENSP00000355566; ENSG00000173726
# ExpressionAtlas	Q15388	baseline and differential
# FUNCTION	TOM20_HUMAN	Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity). {ECO 0000250}. 
# GO_component	GO:0005739	mitochondrion; IDA:HPA.
# GO_component	GO:0005741	mitochondrial outer membrane; IDA:UniProtKB.
# GO_component	GO:0005742	mitochondrial outer membrane translocase complex; NAS:UniProtKB.
# GO_component	GO:0031012	extracellular matrix; IDA:BHF-UCL.
# GO_component	GO:0031307	integral component of mitochondrial outer membrane; IBA:GO_Central.
# GO_component	GO:0044233	ER-mitochondrion membrane contact site; IDA:MGI.
# GO_function	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity; IDA:HGNC.
# GO_function	GO:0030943	mitochondrion targeting sequence binding; IBA:GO_Central.
# GO_function	GO:0051082	unfolded protein binding; IDA:HGNC.
# GO_process	GO:0006626	protein targeting to mitochondrion; IDA:HGNC.
# GO_process	GO:0016031	tRNA import into mitochondrion; IBA:GO_Central.
# GO_process	GO:0016236	macroautophagy; TAS:Reactome.
# GO_process	GO:0030150	protein import into mitochondrial matrix; IBA:GO_Central.
# GO_process	GO:0070096	mitochondrial outer membrane translocase complex assembly; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0051082	unfolded protein binding
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006605	protein targeting
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006914	autophagy
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.960.10	-; 1.
# Genevisible	Q15388	HS
# HGNC	HGNC:20947	TOMM20
# IntAct	Q15388	28
# InterPro	IPR002056	MAS20
# InterPro	IPR022422	MAS20_rcpt_metazoan
# InterPro	IPR023392	Tom20_dom
# MIM	601848	gene
# Organism	TOM20_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12430	PTHR12430
# PDB	4APO	X-ray; 1.90 A; D/E=140-145
# PIR	S68215	S68215
# PIRSF	PIRSF037707	MAS20_rcpt
# PRINTS	PR00351	OM20RECEPTOR
# PRINTS	PR01989	EUOM20RECPTR
# PTM	TOM20_HUMAN	Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. {ECO 0000269|PubMed 24896179, ECO 0000269|PubMed 25621951}. 
# Pfam	PF02064	MAS20
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-1268020	Mitochondrial protein import
# Reactome	R-HSA-5205685	Pink/Parkin Mediated Mitophagy
# Reactome	R-HSA-5689880	Ub-specific processing proteases
# RecName	TOM20_HUMAN	Mitochondrial import receptor subunit TOM20 homolog
# RefSeq	NP_055580	NM_014765.2
# SIMILARITY	Belongs to the Tom20 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	TOM20_HUMAN	Mitochondrion outer membrane {ECO 0000269|PubMed 25764979, ECO 0000269|PubMed 25997101}; Single-pass membrane protein {ECO 0000255}. 
# SUBUNIT	TOM20_HUMAN	Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with TOM22. Interacts with APEX1. {ECO 0000269|PubMed 18331822, ECO 0000269|PubMed 20231292}. 
# SUPFAM	SSF47157	SSF47157
# TIGRFAMs	TIGR00985	3a0801s04tom
# UCSC	uc001hwl	human
# eggNOG	ENOG4111NAH	LUCA
# eggNOG	KOG4056	Eukaryota
BLAST	swissprot:TOM20_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TOM20_HUMAN
BioCyc	ZFISH:ENSG00000173726-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000173726-MONOMER
COXPRESdb	9804	http://coxpresdb.jp/data/gene/9804.shtml
CleanEx	HS_TOMM20	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TOMM20
DIP	DIP-46735N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-46735N
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/0014-5793(95)01010-C	http://dx.doi.org/10.1016/0014-5793(95)01010-C
DOI	10.1016/0014-5793(95)01229-8	http://dx.doi.org/10.1016/0014-5793(95)01229-8
DOI	10.1016/S0378-1119(99)00409-6	http://dx.doi.org/10.1016/S0378-1119(99)00409-6
DOI	10.1016/j.bbamcr.2015.03.004	http://dx.doi.org/10.1016/j.bbamcr.2015.03.004
DOI	10.1016/j.bbrc.2008.02.150	http://dx.doi.org/10.1016/j.bbrc.2008.02.150
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/nature13418	http://dx.doi.org/10.1038/nature13418
DOI	10.1038/ncb3097	http://dx.doi.org/10.1038/ncb3097
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/jbc.M109.069591	http://dx.doi.org/10.1074/jbc.M109.069591
DOI	10.1093/dnares/1.1.27	http://dx.doi.org/10.1093/dnares/1.1.27
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.7554/eLife.06265	http://dx.doi.org/10.7554/eLife.06265
EMBL	AF126958	http://www.ebi.ac.uk/ena/data/view/AF126958
EMBL	AF126959	http://www.ebi.ac.uk/ena/data/view/AF126959
EMBL	AF126960	http://www.ebi.ac.uk/ena/data/view/AF126960
EMBL	AF126961	http://www.ebi.ac.uk/ena/data/view/AF126961
EMBL	AF126962	http://www.ebi.ac.uk/ena/data/view/AF126962
EMBL	AK289810	http://www.ebi.ac.uk/ena/data/view/AK289810
EMBL	AL732292	http://www.ebi.ac.uk/ena/data/view/AL732292
EMBL	BC000882	http://www.ebi.ac.uk/ena/data/view/BC000882
EMBL	BC066335	http://www.ebi.ac.uk/ena/data/view/BC066335
EMBL	BC071994	http://www.ebi.ac.uk/ena/data/view/BC071994
EMBL	BC100286	http://www.ebi.ac.uk/ena/data/view/BC100286
EMBL	BC107851	http://www.ebi.ac.uk/ena/data/view/BC107851
EMBL	CH471098	http://www.ebi.ac.uk/ena/data/view/CH471098
EMBL	CR456718	http://www.ebi.ac.uk/ena/data/view/CR456718
EMBL	D13641	http://www.ebi.ac.uk/ena/data/view/D13641
Ensembl	ENST00000366607	http://www.ensembl.org/id/ENST00000366607
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005741	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005741
GO_component	GO:0005742	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005742
GO_component	GO:0031012	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031012
GO_component	GO:0031307	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031307
GO_component	GO:0044233	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044233
GO_function	GO:0015450	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015450
GO_function	GO:0030943	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030943
GO_function	GO:0051082	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051082
GO_process	GO:0006626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006626
GO_process	GO:0016031	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016031
GO_process	GO:0016236	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016236
GO_process	GO:0030150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030150
GO_process	GO:0070096	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070096
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0051082	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051082
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006914	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006914
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.960.10	http://www.cathdb.info/version/latest/superfamily/1.20.960.10
GeneCards	TOMM20	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TOMM20
GeneID	9804	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9804
GeneTree	ENSGT00390000011698	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000011698
HGNC	HGNC:20947	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20947
HOGENOM	HOG000006671	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006671&db=HOGENOM6
HOVERGEN	HBG057315	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG057315&db=HOVERGEN
HPA	CAB005585	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB005585
HPA	HPA011562	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA011562
InParanoid	Q15388	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q15388
IntAct	Q15388	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q15388*
InterPro	IPR002056	http://www.ebi.ac.uk/interpro/entry/IPR002056
InterPro	IPR022422	http://www.ebi.ac.uk/interpro/entry/IPR022422
InterPro	IPR023392	http://www.ebi.ac.uk/interpro/entry/IPR023392
Jabion	9804	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9804
KEGG_Gene	hsa:9804	http://www.genome.jp/dbget-bin/www_bget?hsa:9804
MIM	601848	http://www.ncbi.nlm.nih.gov/omim/601848
MINT	MINT-1403841	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1403841
OMA	AMLIIKM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AMLIIKM
OrthoDB	EOG091G0Z80	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0Z80
PANTHER	PTHR12430	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12430
PDB	4APO	http://www.ebi.ac.uk/pdbe-srv/view/entry/4APO
PDBsum	4APO	http://www.ebi.ac.uk/pdbsum/4APO
PRINTS	PR00351	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00351
PRINTS	PR01989	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01989
PSORT	swissprot:TOM20_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TOM20_HUMAN
PSORT-B	swissprot:TOM20_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TOM20_HUMAN
PSORT2	swissprot:TOM20_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TOM20_HUMAN
Pfam	PF02064	http://pfam.xfam.org/family/PF02064
PharmGKB	PA134964372	http://www.pharmgkb.org/do/serve?objId=PA134964372&objCls=Gene
Phobius	swissprot:TOM20_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TOM20_HUMAN
PhylomeDB	Q15388	http://phylomedb.org/?seqid=Q15388
ProteinModelPortal	Q15388	http://www.proteinmodelportal.org/query/uniprot/Q15388
PubMed	10548729	http://www.ncbi.nlm.nih.gov/pubmed/10548729
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	18331822	http://www.ncbi.nlm.nih.gov/pubmed/18331822
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	20231292	http://www.ncbi.nlm.nih.gov/pubmed/20231292
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	24896179	http://www.ncbi.nlm.nih.gov/pubmed/24896179
PubMed	25621951	http://www.ncbi.nlm.nih.gov/pubmed/25621951
PubMed	25764979	http://www.ncbi.nlm.nih.gov/pubmed/25764979
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	25997101	http://www.ncbi.nlm.nih.gov/pubmed/25997101
PubMed	7498524	http://www.ncbi.nlm.nih.gov/pubmed/7498524
PubMed	7584026	http://www.ncbi.nlm.nih.gov/pubmed/7584026
PubMed	7589431	http://www.ncbi.nlm.nih.gov/pubmed/7589431
Reactome	R-HSA-1268020	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1268020
Reactome	R-HSA-5205685	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5205685
Reactome	R-HSA-5689880	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5689880
RefSeq	NP_055580	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055580
SMR	Q15388	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q15388
STRING	9606.ENSP00000355566	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000355566&targetmode=cogs
SUPFAM	SSF47157	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47157
TIGRFAMs	TIGR00985	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00985
UCSC	uc001hwl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001hwl&org=rat
UniGene	Hs.533192	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.533192
UniProtKB	TOM20_HUMAN	http://www.uniprot.org/uniprot/TOM20_HUMAN
UniProtKB-AC	Q15388	http://www.uniprot.org/uniprot/Q15388
charge	swissprot:TOM20_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TOM20_HUMAN
eggNOG	ENOG4111NAH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111NAH
eggNOG	KOG4056	http://eggnogapi.embl.de/nog_data/html/tree/KOG4056
epestfind	swissprot:TOM20_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TOM20_HUMAN
garnier	swissprot:TOM20_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TOM20_HUMAN
helixturnhelix	swissprot:TOM20_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TOM20_HUMAN
hmoment	swissprot:TOM20_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TOM20_HUMAN
iep	swissprot:TOM20_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TOM20_HUMAN
inforesidue	swissprot:TOM20_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TOM20_HUMAN
neXtProt	NX_Q15388	http://www.nextprot.org/db/entry/NX_Q15388
octanol	swissprot:TOM20_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TOM20_HUMAN
pepcoil	swissprot:TOM20_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TOM20_HUMAN
pepdigest	swissprot:TOM20_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TOM20_HUMAN
pepinfo	swissprot:TOM20_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TOM20_HUMAN
pepnet	swissprot:TOM20_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TOM20_HUMAN
pepstats	swissprot:TOM20_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TOM20_HUMAN
pepwheel	swissprot:TOM20_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TOM20_HUMAN
pepwindow	swissprot:TOM20_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TOM20_HUMAN
sigcleave	swissprot:TOM20_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TOM20_HUMAN
## Database	ID	URL or Descriptions
# AltName	TOM7_HUMAN	Translocase of outer membrane 7 kDa subunit homolog
# BioGrid	120030	18
# ChiTaRS	TOMM7	human
# Ensembl	ENST00000358435	ENSP00000351214; ENSG00000196683
# ExpressionAtlas	Q9P0U1	baseline and differential
# FUNCTION	TOM7_HUMAN	Required for assembly and stability of the TOM complex. Positive regulator of PARK2 translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria. {ECO 0000269|PubMed 18331822, ECO 0000269|PubMed 24270810}. 
# GO_component	GO:0005739	mitochondrion; IDA:BHF-UCL.
# GO_component	GO:0005741	mitochondrial outer membrane; TAS:Reactome.
# GO_component	GO:0005742	mitochondrial outer membrane translocase complex; IDA:BHF-UCL.
# GO_component	GO:0031307	integral component of mitochondrial outer membrane; IBA:GO_Central.
# GO_function	GO:0008320	protein transmembrane transporter activity; TAS:BHF-UCL.
# GO_process	GO:0006626	protein targeting to mitochondrion; TAS:BHF-UCL.
# GO_process	GO:0016236	macroautophagy; TAS:Reactome.
# GO_process	GO:0030150	protein import into mitochondrial matrix; IBA:GO_Central.
# GO_process	GO:0031647	regulation of protein stability; IMP:ParkinsonsUK-UCL.
# GO_process	GO:0045040	protein import into mitochondrial outer membrane; IBA:GO_Central.
# GO_process	GO:0098779	mitophagy in response to mitochondrial depolarization; IMP:ParkinsonsUK-UCL.
# GO_process	GO:1903955	positive regulation of protein targeting to mitochondrion; IMP:ParkinsonsUK-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006605	protein targeting
# GOslim_process	GO:0006914	autophagy
# GOslim_process	GO:0007005	mitochondrion organization
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# GOslim_process	GO:0061024	membrane organization
# Genevisible	Q9P0U1	HS
# HGNC	HGNC:21648	TOMM7
# INTERACTION	TOM7_HUMAN	Q9NS69 TOMM22; NbExp=2; IntAct=EBI-1180558, EBI-1047508; 
# IntAct	Q9P0U1	2
# InterPro	IPR012621	Tom7
# MIM	607980	gene
# Organism	TOM7_HUMAN	Homo sapiens (Human)
# Pfam	PF08038	Tom7
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-1268020	Mitochondrial protein import
# Reactome	R-HSA-5205685	Pink/Parkin Mediated Mitophagy
# RecName	TOM7_HUMAN	Mitochondrial import receptor subunit TOM7 homolog
# RefSeq	NP_061932	NM_019059.3
# SIMILARITY	Belongs to the Tom7 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	TOM7_HUMAN	Mitochondrion outer membrane {ECO 0000269|PubMed 12198123}; Single-pass membrane protein {ECO 0000269|PubMed 12198123}. 
# SUBUNIT	TOM7_HUMAN	Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). {ECO 0000269|PubMed 12198123, ECO 0000269|PubMed 18331822}. 
# UCSC	uc003svk	human
# eggNOG	ENOG41123F4	LUCA
# eggNOG	KOG4449	Eukaryota
BLAST	swissprot:TOM7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TOM7_HUMAN
BioCyc	ZFISH:G66-32949-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32949-MONOMER
COXPRESdb	54543	http://coxpresdb.jp/data/gene/54543.shtml
CleanEx	HS_TOMM7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TOMM7
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.bbrc.2008.02.150	http://dx.doi.org/10.1016/j.bbrc.2008.02.150
DOI	10.1038/nature12748	http://dx.doi.org/10.1038/nature12748
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1073/pnas.160270997	http://dx.doi.org/10.1073/pnas.160270997
DOI	10.1074/jbc.M205613200	http://dx.doi.org/10.1074/jbc.M205613200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF150733	http://www.ebi.ac.uk/ena/data/view/AF150733
EMBL	AJ011007	http://www.ebi.ac.uk/ena/data/view/AJ011007
EMBL	BC001732	http://www.ebi.ac.uk/ena/data/view/BC001732
Ensembl	ENST00000358435	http://www.ensembl.org/id/ENST00000358435
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005741	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005741
GO_component	GO:0005742	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005742
GO_component	GO:0031307	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031307
GO_function	GO:0008320	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008320
GO_process	GO:0006626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006626
GO_process	GO:0016236	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016236
GO_process	GO:0030150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030150
GO_process	GO:0031647	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031647
GO_process	GO:0045040	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045040
GO_process	GO:0098779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098779
GO_process	GO:1903955	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903955
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605
GOslim_process	GO:0006914	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006914
GOslim_process	GO:0007005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007005
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
GeneCards	TOMM7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TOMM7
GeneID	54543	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54543
GeneTree	ENSGT00390000014833	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000014833
HGNC	HGNC:21648	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:21648
HOVERGEN	HBG065915	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG065915&db=HOVERGEN
InParanoid	Q9P0U1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9P0U1
IntAct	Q9P0U1	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9P0U1*
InterPro	IPR012621	http://www.ebi.ac.uk/interpro/entry/IPR012621
Jabion	54543	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=54543
KEGG_Gene	hsa:54543	http://www.genome.jp/dbget-bin/www_bget?hsa:54543
MIM	607980	http://www.ncbi.nlm.nih.gov/omim/607980
PSORT	swissprot:TOM7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TOM7_HUMAN
PSORT-B	swissprot:TOM7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TOM7_HUMAN
PSORT2	swissprot:TOM7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TOM7_HUMAN
Pfam	PF08038	http://pfam.xfam.org/family/PF08038
PharmGKB	PA134864325	http://www.pharmgkb.org/do/serve?objId=PA134864325&objCls=Gene
Phobius	swissprot:TOM7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TOM7_HUMAN
PhylomeDB	Q9P0U1	http://phylomedb.org/?seqid=Q9P0U1
ProteinModelPortal	Q9P0U1	http://www.proteinmodelportal.org/query/uniprot/Q9P0U1
PubMed	10647823	http://www.ncbi.nlm.nih.gov/pubmed/10647823
PubMed	10931946	http://www.ncbi.nlm.nih.gov/pubmed/10931946
PubMed	12198123	http://www.ncbi.nlm.nih.gov/pubmed/12198123
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18331822	http://www.ncbi.nlm.nih.gov/pubmed/18331822
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	24270810	http://www.ncbi.nlm.nih.gov/pubmed/24270810
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-1268020	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1268020
Reactome	R-HSA-5205685	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5205685
RefSeq	NP_061932	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061932
STRING	9606.ENSP00000351214	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000351214&targetmode=cogs
UCSC	uc003svk	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003svk&org=rat
UniGene	Hs.112318	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.112318
UniProtKB	TOM7_HUMAN	http://www.uniprot.org/uniprot/TOM7_HUMAN
UniProtKB-AC	Q9P0U1	http://www.uniprot.org/uniprot/Q9P0U1
charge	swissprot:TOM7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TOM7_HUMAN
eggNOG	ENOG41123F4	http://eggnogapi.embl.de/nog_data/html/tree/ENOG41123F4
eggNOG	KOG4449	http://eggnogapi.embl.de/nog_data/html/tree/KOG4449
epestfind	swissprot:TOM7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TOM7_HUMAN
garnier	swissprot:TOM7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TOM7_HUMAN
helixturnhelix	swissprot:TOM7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TOM7_HUMAN
hmoment	swissprot:TOM7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TOM7_HUMAN
iep	swissprot:TOM7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TOM7_HUMAN
inforesidue	swissprot:TOM7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TOM7_HUMAN
neXtProt	NX_Q9P0U1	http://www.nextprot.org/db/entry/NX_Q9P0U1
octanol	swissprot:TOM7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TOM7_HUMAN
pepcoil	swissprot:TOM7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TOM7_HUMAN
pepdigest	swissprot:TOM7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TOM7_HUMAN
pepinfo	swissprot:TOM7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TOM7_HUMAN
pepnet	swissprot:TOM7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TOM7_HUMAN
pepstats	swissprot:TOM7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TOM7_HUMAN
pepwheel	swissprot:TOM7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TOM7_HUMAN
pepwindow	swissprot:TOM7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TOM7_HUMAN
sigcleave	swissprot:TOM7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TOM7_HUMAN
## Database	ID	URL or Descriptions
# AltName	CX7A2_HUMAN	Cytochrome c oxidase subunit VIIa-liver/heart
# BioGrid	107740	19
# CDD	cd00928	Cyt_c_Oxidase_VIIa
# ChiTaRS	COX7A2	human
# Ensembl	ENST00000230459	ENSP00000230459; ENSG00000112695
# FUNCTION	CX7A2_HUMAN	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. 
# GO_component	GO:0005746	mitochondrial respiratory chain; IEA:InterPro.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0004129	cytochrome-c oxidase activity; IEA:InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# Gene3D	4.10.91.10	-; 1.
# HGNC	HGNC:2288	COX7A2
# IntAct	P14406	4
# InterPro	IPR003177	Cyt_c_oxidase_su7a
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	123996	gene
# Organism	CX7A2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10510	PTHR10510
# PIR	S06897	OSHU7L
# Proteomes	UP000005640	Unplaced
# RecName	CX7A2_HUMAN	Cytochrome c oxidase subunit 7A2, mitochondrial
# RefSeq	NP_001856	NM_001865.3
# SEQUENCE CAUTION	Sequence=CAI19899.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the cytochrome c oxidase VIIa family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	CX7A2_HUMAN	Mitochondrion inner membrane. 
# SUBUNIT	Interacts with PET100. {ECO:0000269|PubMed	22356826}. 
# SUPFAM	SSF81419	SSF81419
# TCDB	3.D.4.11	the proton-translocating cytochrome oxidase (cox) superfamily
# eggNOG	ENOG410IZJ9	Eukaryota
# eggNOG	ENOG41124EQ	LUCA
BLAST	swissprot:CX7A2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CX7A2_HUMAN
BioCyc	ZFISH:HS03606-MONOMER	http://biocyc.org/getid?id=ZFISH:HS03606-MONOMER
COXPRESdb	1347	http://coxpresdb.jp/data/gene/1347.shtml
CleanEx	HS_COX7A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_COX7A2
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/nar/17.17.7107	http://dx.doi.org/10.1093/nar/17.17.7107
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1432-1033.1992.tb19847.x	http://dx.doi.org/10.1111/j.1432-1033.1992.tb19847.x
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1186/gb-2012-13-2-r12	http://dx.doi.org/10.1186/gb-2012-13-2-r12
EMBL	AF134406	http://www.ebi.ac.uk/ena/data/view/AF134406
EMBL	AK312154	http://www.ebi.ac.uk/ena/data/view/AK312154
EMBL	AL080250	http://www.ebi.ac.uk/ena/data/view/AL080250
EMBL	BC101826	http://www.ebi.ac.uk/ena/data/view/BC101826
EMBL	BC101828	http://www.ebi.ac.uk/ena/data/view/BC101828
EMBL	CR407646	http://www.ebi.ac.uk/ena/data/view/CR407646
EMBL	CR542125	http://www.ebi.ac.uk/ena/data/view/CR542125
EMBL	X15822	http://www.ebi.ac.uk/ena/data/view/X15822
Ensembl	ENST00000230459	http://www.ensembl.org/id/ENST00000230459
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005746	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005746
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0004129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004129
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
Gene3D	4.10.91.10	http://www.cathdb.info/version/latest/superfamily/4.10.91.10
GeneCards	COX7A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=COX7A2
GeneID	1347	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1347
H-InvDB	HIX0200919	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0200919
HGNC	HGNC:2288	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2288
HOGENOM	HOG000264231	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264231&db=HOGENOM6
HOVERGEN	HBG051095	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051095&db=HOVERGEN
InParanoid	P14406	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P14406
IntAct	P14406	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P14406*
InterPro	IPR003177	http://www.ebi.ac.uk/interpro/entry/IPR003177
Jabion	1347	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1347
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Gene	hsa:1347	http://www.genome.jp/dbget-bin/www_bget?hsa:1347
KEGG_Orthology	KO:K02270	http://www.genome.jp/dbget-bin/www_bget?KO:K02270
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	123996	http://www.ncbi.nlm.nih.gov/omim/123996
PANTHER	PTHR10510	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10510
PSORT	swissprot:CX7A2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CX7A2_HUMAN
PSORT-B	swissprot:CX7A2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CX7A2_HUMAN
PSORT2	swissprot:CX7A2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CX7A2_HUMAN
PharmGKB	PA26806	http://www.pharmgkb.org/do/serve?objId=PA26806&objCls=Gene
Phobius	swissprot:CX7A2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CX7A2_HUMAN
PhylomeDB	P14406	http://phylomedb.org/?seqid=P14406
ProteinModelPortal	P14406	http://www.proteinmodelportal.org/query/uniprot/P14406
PubMed	11004498	http://www.ncbi.nlm.nih.gov/pubmed/11004498
PubMed	1309697	http://www.ncbi.nlm.nih.gov/pubmed/1309697
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22356826	http://www.ncbi.nlm.nih.gov/pubmed/22356826
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	2550906	http://www.ncbi.nlm.nih.gov/pubmed/2550906
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
RefSeq	NP_001856	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001856
SMR	P14406	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P14406
STRING	9606.ENSP00000359098	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000359098&targetmode=cogs
SUPFAM	SSF81419	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81419
TCDB	3.D.4.11	http://www.tcdb.org/search/result.php?tc=3.D.4.11
UniGene	Hs.70312	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.70312
UniProtKB	CX7A2_HUMAN	http://www.uniprot.org/uniprot/CX7A2_HUMAN
UniProtKB-AC	P14406	http://www.uniprot.org/uniprot/P14406
charge	swissprot:CX7A2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CX7A2_HUMAN
eggNOG	ENOG410IZJ9	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IZJ9
eggNOG	ENOG41124EQ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG41124EQ
epestfind	swissprot:CX7A2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CX7A2_HUMAN
garnier	swissprot:CX7A2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CX7A2_HUMAN
helixturnhelix	swissprot:CX7A2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CX7A2_HUMAN
hmoment	swissprot:CX7A2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CX7A2_HUMAN
iep	swissprot:CX7A2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CX7A2_HUMAN
inforesidue	swissprot:CX7A2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CX7A2_HUMAN
neXtProt	NX_P14406	http://www.nextprot.org/db/entry/NX_P14406
octanol	swissprot:CX7A2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CX7A2_HUMAN
pepcoil	swissprot:CX7A2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CX7A2_HUMAN
pepdigest	swissprot:CX7A2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CX7A2_HUMAN
pepinfo	swissprot:CX7A2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CX7A2_HUMAN
pepnet	swissprot:CX7A2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CX7A2_HUMAN
pepstats	swissprot:CX7A2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CX7A2_HUMAN
pepwheel	swissprot:CX7A2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CX7A2_HUMAN
pepwindow	swissprot:CX7A2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CX7A2_HUMAN
sigcleave	swissprot:CX7A2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CX7A2_HUMAN
## Database	ID	URL or Descriptions
# Ensembl	ENST00000344941	ENSP00000340402; ENSG00000188991
# FUNCTION	S15A5_HUMAN	Proton oligopeptide cotransporter. {ECO 0000305}. 
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_process	GO:0015031	protein transport; IEA:UniProtKB-KW.
# GO_process	GO:0015833	peptide transport; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# HGNC	HGNC:33455	SLC15A5
# InterPro	IPR000109	POT_fam
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02001	Solute carrier family
# Organism	S15A5_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11654	PTHR11654
# Pfam	PF00854	PTR2
# Proteomes	UP000005640	Chromosome 12
# RecName	S15A5_HUMAN	Solute carrier family 15 member 5
# RefSeq	NP_001164269	NM_001170798.1
# SIMILARITY	Belongs to the PTR2/POT transporter (TC 2.A.17) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S15A5_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF103473	SSF103473; 3
# TCDB	2.A.17.3.10	the proton-dependent oligopeptide transporter (pot/ptr) family
# UCSC	uc021qvs	human
# eggNOG	COG3104	LUCA
# eggNOG	KOG1237	Eukaryota
BLAST	swissprot:S15A5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S15A5_HUMAN
BioCyc	ZFISH:G66-32045-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32045-MONOMER
COXPRESdb	729025	http://coxpresdb.jp/data/gene/729025.shtml
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
EMBL	AC073574	http://www.ebi.ac.uk/ena/data/view/AC073574
Ensembl	ENST00000344941	http://www.ensembl.org/id/ENST00000344941
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_process	GO:0015031	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031
GO_process	GO:0015833	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015833
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC15A5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC15A5
GeneID	729025	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=729025
GeneTree	ENSGT00530000062961	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062961
HGNC	HGNC:33455	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:33455
HOGENOM	HOG000060235	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000060235&db=HOGENOM6
HPA	HPA041638	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA041638
InParanoid	A6NIM6	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=A6NIM6
InterPro	IPR000109	http://www.ebi.ac.uk/interpro/entry/IPR000109
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	729025	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=729025
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:729025	http://www.genome.jp/dbget-bin/www_bget?hsa:729025
KEGG_Orthology	KO:K14639	http://www.genome.jp/dbget-bin/www_bget?KO:K14639
OMA	FYLVLQY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FYLVLQY
OrthoDB	EOG091G0GF9	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0GF9
PANTHER	PTHR11654	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11654
PSORT	swissprot:S15A5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S15A5_HUMAN
PSORT-B	swissprot:S15A5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S15A5_HUMAN
PSORT2	swissprot:S15A5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S15A5_HUMAN
Pfam	PF00854	http://pfam.xfam.org/family/PF00854
PharmGKB	PA164725785	http://www.pharmgkb.org/do/serve?objId=PA164725785&objCls=Gene
Phobius	swissprot:S15A5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S15A5_HUMAN
PhylomeDB	A6NIM6	http://phylomedb.org/?seqid=A6NIM6
ProteinModelPortal	A6NIM6	http://www.proteinmodelportal.org/query/uniprot/A6NIM6
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
RefSeq	NP_001164269	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001164269
STRING	9606.ENSP00000340402	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000340402&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.17.3.10	http://www.tcdb.org/search/result.php?tc=2.A.17.3.10
UCSC	uc021qvs	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc021qvs&org=rat
UniGene	Hs.692712	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.692712
UniProtKB	S15A5_HUMAN	http://www.uniprot.org/uniprot/S15A5_HUMAN
UniProtKB-AC	A6NIM6	http://www.uniprot.org/uniprot/A6NIM6
charge	swissprot:S15A5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S15A5_HUMAN
eggNOG	COG3104	http://eggnogapi.embl.de/nog_data/html/tree/COG3104
eggNOG	KOG1237	http://eggnogapi.embl.de/nog_data/html/tree/KOG1237
epestfind	swissprot:S15A5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S15A5_HUMAN
garnier	swissprot:S15A5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S15A5_HUMAN
helixturnhelix	swissprot:S15A5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S15A5_HUMAN
hmoment	swissprot:S15A5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S15A5_HUMAN
iep	swissprot:S15A5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S15A5_HUMAN
inforesidue	swissprot:S15A5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S15A5_HUMAN
neXtProt	NX_A6NIM6	http://www.nextprot.org/db/entry/NX_A6NIM6
octanol	swissprot:S15A5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S15A5_HUMAN
pepcoil	swissprot:S15A5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S15A5_HUMAN
pepdigest	swissprot:S15A5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S15A5_HUMAN
pepinfo	swissprot:S15A5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S15A5_HUMAN
pepnet	swissprot:S15A5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S15A5_HUMAN
pepstats	swissprot:S15A5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S15A5_HUMAN
pepwheel	swissprot:S15A5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S15A5_HUMAN
pepwindow	swissprot:S15A5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S15A5_HUMAN
sigcleave	swissprot:S15A5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S15A5_HUMAN
## Database	ID	URL or Descriptions
# AltName	ATPD_HUMAN	F-ATPase delta subunit
# BioGrid	106998	50
# CDD	cd12152	F1-ATPase_delta
# ChiTaRS	ATP5D	human
# DrugBank	DB00228	Enflurane
# DrugBank	DB00753	Isoflurane
# DrugBank	DB01028	Methoxyflurane
# DrugBank	DB01159	Halothane
# DrugBank	DB01189	Desflurane
# DrugBank	DB01236	Sevoflurane
# Ensembl	ENST00000215375	ENSP00000215375; ENSG00000099624
# Ensembl	ENST00000395633	ENSP00000378995; ENSG00000099624
# Ensembl	ENST00000591660	ENSP00000464863; ENSG00000099624
# ExpressionAtlas	P30049	baseline and differential
# FUNCTION	ATPD_HUMAN	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. 
# GO_component	GO:0000275	mitochondrial proton-transporting ATP synthase complex, catalytic core F(1); NAS:UniProtKB.
# GO_component	GO:0005739	mitochondrion; NAS:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; ISS:UniProtKB.
# GO_component	GO:0005753	mitochondrial proton-transporting ATP synthase complex; IDA:UniProtKB.
# GO_component	GO:0005759	mitochondrial matrix; TAS:Reactome.
# GO_function	GO:0005215	transporter activity; NAS:UniProtKB.
# GO_function	GO:0022857	transmembrane transporter activity; IC:UniProtKB.
# GO_function	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism; IEA:InterPro.
# GO_process	GO:0006119	oxidative phosphorylation; NAS:UniProtKB.
# GO_process	GO:0006754	ATP biosynthetic process; NAS:UniProtKB.
# GO_process	GO:0015986	ATP synthesis coupled proton transport; IBA:GO_Central.
# GO_process	GO:0042776	mitochondrial ATP synthesis coupled proton transport; NAS:UniProtKB.
# GO_process	GO:0046688	response to copper ion; NAS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.15.10	-; 1.
# Genevisible	P30049	HS
# HAMAP	MF_00530	ATP_synth_epsil_bac
# HGNC	HGNC:837	ATP5D
# IntAct	P30049	15
# InterPro	IPR001469	ATP_synth_F1_dsu/esu
# InterPro	IPR020546	ATP_synth_F1_dsu/esu_N
# InterPro	IPR020547	ATP_synth_F1_dsu/esu_C
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	603150	gene
# Organism	ATPD_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR13822	PTHR13822
# PIR	S22348	S22348
# Pfam	PF02823	ATP-synt_DE_N
# ProDom	PD000944	ATPase_F1-cplx_dsu/esu
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-163210	Formation of ATP by chemiosmotic coupling
# RecName	ATPD_HUMAN	ATP synthase subunit delta, mitochondrial
# RefSeq	NP_001001975	NM_001001975.1
# RefSeq	NP_001678	NM_001687.4
# SIMILARITY	Belongs to the ATPase epsilon chain family. {ECO	0000305}.
# SUBCELLULAR LOCATION	ATPD_HUMAN	Mitochondrion. Mitochondrion inner membrane. 
# SUBUNIT	F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) seems to have nine subunits	 a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity). {ECO:0000250}. 
# SUPFAM	SSF46604	SSF46604
# SUPFAM	SSF51344	SSF51344
# TIGRFAMs	TIGR01216	ATP_synt_epsi
# UCSC	uc002lrn	human
# eggNOG	COG0355	LUCA
# eggNOG	KOG1758	Eukaryota
BLAST	swissprot:ATPD_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ATPD_HUMAN
BioCyc	ZFISH:HS01900-MONOMER	http://biocyc.org/getid?id=ZFISH:HS01900-MONOMER
COG	COG0355	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0355
COXPRESdb	513	http://coxpresdb.jp/data/gene/513.shtml
CleanEx	HS_ATP5D	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP5D
DOI	10.1002/elps.11501301201	http://dx.doi.org/10.1002/elps.11501301201
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/0167-4781(92)90477-H	http://dx.doi.org/10.1016/0167-4781(92)90477-H
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DrugBank	DB00228	http://www.drugbank.ca/drugs/DB00228
DrugBank	DB00753	http://www.drugbank.ca/drugs/DB00753
DrugBank	DB01028	http://www.drugbank.ca/drugs/DB01028
DrugBank	DB01159	http://www.drugbank.ca/drugs/DB01159
DrugBank	DB01189	http://www.drugbank.ca/drugs/DB01189
DrugBank	DB01236	http://www.drugbank.ca/drugs/DB01236
EMBL	AC004221	http://www.ebi.ac.uk/ena/data/view/AC004221
EMBL	BC002389	http://www.ebi.ac.uk/ena/data/view/BC002389
EMBL	BC004426	http://www.ebi.ac.uk/ena/data/view/BC004426
EMBL	BC018079	http://www.ebi.ac.uk/ena/data/view/BC018079
EMBL	CH471139	http://www.ebi.ac.uk/ena/data/view/CH471139
EMBL	CH471139	http://www.ebi.ac.uk/ena/data/view/CH471139
EMBL	CH471139	http://www.ebi.ac.uk/ena/data/view/CH471139
EMBL	CR542218	http://www.ebi.ac.uk/ena/data/view/CR542218
EMBL	S87916	http://www.ebi.ac.uk/ena/data/view/S87916
EMBL	S87918	http://www.ebi.ac.uk/ena/data/view/S87918
EMBL	X63422	http://www.ebi.ac.uk/ena/data/view/X63422
EMBL	X63423	http://www.ebi.ac.uk/ena/data/view/X63423
Ensembl	ENST00000215375	http://www.ensembl.org/id/ENST00000215375
Ensembl	ENST00000395633	http://www.ensembl.org/id/ENST00000395633
Ensembl	ENST00000591660	http://www.ensembl.org/id/ENST00000591660
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000275	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000275
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005753	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005753
GO_component	GO:0005759	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005759
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GO_function	GO:0046933	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046933
GO_process	GO:0006119	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006119
GO_process	GO:0006754	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006754
GO_process	GO:0015986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015986
GO_process	GO:0042776	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042776
GO_process	GO:0046688	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046688
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.15.10	http://www.cathdb.info/version/latest/superfamily/2.60.15.10
GeneCards	ATP5D	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP5D
GeneID	513	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=513
GeneTree	ENSGT00390000017576	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000017576
HAMAP	MF_00530	http://hamap.expasy.org/unirule/MF_00530
HGNC	HGNC:837	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:837
HOGENOM	HOG000216023	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000216023&db=HOGENOM6
HOVERGEN	HBG001856	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG001856&db=HOVERGEN
HPA	HPA002865	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA002865
InParanoid	P30049	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30049
IntAct	P30049	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30049*
InterPro	IPR001469	http://www.ebi.ac.uk/interpro/entry/IPR001469
InterPro	IPR020546	http://www.ebi.ac.uk/interpro/entry/IPR020546
InterPro	IPR020547	http://www.ebi.ac.uk/interpro/entry/IPR020547
Jabion	513	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=513
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:513	http://www.genome.jp/dbget-bin/www_bget?hsa:513
KEGG_Orthology	KO:K02134	http://www.genome.jp/dbget-bin/www_bget?KO:K02134
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	603150	http://www.ncbi.nlm.nih.gov/omim/603150
OMA	PQMSFTF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PQMSFTF
OrthoDB	EOG091G1AP6	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G1AP6
PANTHER	PTHR13822	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13822
PSORT	swissprot:ATPD_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ATPD_HUMAN
PSORT-B	swissprot:ATPD_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ATPD_HUMAN
PSORT2	swissprot:ATPD_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ATPD_HUMAN
Pfam	PF02823	http://pfam.xfam.org/family/PF02823
PharmGKB	PA25127	http://www.pharmgkb.org/do/serve?objId=PA25127&objCls=Gene
Phobius	swissprot:ATPD_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ATPD_HUMAN
PhylomeDB	P30049	http://phylomedb.org/?seqid=P30049
ProteinModelPortal	P30049	http://www.proteinmodelportal.org/query/uniprot/P30049
PubMed	1286669	http://www.ncbi.nlm.nih.gov/pubmed/1286669
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	1531933	http://www.ncbi.nlm.nih.gov/pubmed/1531933
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-163210	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-163210
RefSeq	NP_001001975	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001001975
RefSeq	NP_001678	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001678
SMR	P30049	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30049
STRING	9606.ENSP00000215375	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000215375&targetmode=cogs
STRING	COG0355	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0355&targetmode=cogs
SUPFAM	SSF46604	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46604
SUPFAM	SSF51344	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51344
SWISS-2DPAGE	P30049	http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P30049
TIGRFAMs	TIGR01216	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01216
UCSC	uc002lrn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002lrn&org=rat
UniGene	Hs.418668	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.418668
UniProtKB	ATPD_HUMAN	http://www.uniprot.org/uniprot/ATPD_HUMAN
UniProtKB-AC	P30049	http://www.uniprot.org/uniprot/P30049
charge	swissprot:ATPD_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ATPD_HUMAN
eggNOG	COG0355	http://eggnogapi.embl.de/nog_data/html/tree/COG0355
eggNOG	KOG1758	http://eggnogapi.embl.de/nog_data/html/tree/KOG1758
epestfind	swissprot:ATPD_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ATPD_HUMAN
garnier	swissprot:ATPD_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ATPD_HUMAN
helixturnhelix	swissprot:ATPD_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATPD_HUMAN
hmoment	swissprot:ATPD_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ATPD_HUMAN
iep	swissprot:ATPD_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ATPD_HUMAN
inforesidue	swissprot:ATPD_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ATPD_HUMAN
neXtProt	NX_P30049	http://www.nextprot.org/db/entry/NX_P30049
octanol	swissprot:ATPD_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ATPD_HUMAN
pepcoil	swissprot:ATPD_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ATPD_HUMAN
pepdigest	swissprot:ATPD_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ATPD_HUMAN
pepinfo	swissprot:ATPD_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ATPD_HUMAN
pepnet	swissprot:ATPD_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ATPD_HUMAN
pepstats	swissprot:ATPD_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ATPD_HUMAN
pepwheel	swissprot:ATPD_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ATPD_HUMAN
pepwindow	swissprot:ATPD_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ATPD_HUMAN
sigcleave	swissprot:ATPD_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ATPD_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S4A7_HUMAN	Event=Alternative splicing; Named isoforms=14; Name=1; Synonyms=mNBC3, NBCn1-A; IsoId=Q9Y6M7-1; Sequence=Displayed; Name=2; Synonyms=NBCn1-F; IsoId=Q9Y6M7-2; Sequence=VSP_047844; Note=Contains a phosphoserine at position 258. Contains a phosphoserine at position 255. {ECO 0000244|PubMed 18669648, ECO 0000244|PubMed 19690332, ECO 0000244|PubMed 20068231, ECO 0000244|PubMed 21406692}; Name=3; IsoId=Q9Y6M7-3; Sequence=VSP_047839, VSP_047842, VSP_047844, VSP_047849; Note=Contains a phosphoserine at position 168. Contains a phosphoserine at position 1010. Contains a phosphoserine at position 1016. Contains a phosphoserine at position 165. Contains a phosphoserine at position 1007. {ECO 0000244|PubMed 18669648, ECO 0000244|PubMed 19690332, ECO 0000244|PubMed 20068231, ECO 0000244|PubMed 21406692}; Name=4; IsoId=Q9Y6M7-4; Sequence=VSP_047839, VSP_047842, VSP_047844; Note=Contains a phosphoserine at position 168. Contains a phosphoserine at position 165. {ECO 0000244|PubMed 18669648, ECO 0000244|PubMed 19690332, ECO 0000244|PubMed 20068231, ECO 0000244|PubMed 21406692}; Name=5; IsoId=Q9Y6M7-5; Sequence=VSP_047838, VSP_047845, VSP_047848; Note=No experimental confirmation available. Contains a phosphoserine at position 774. Contains a phosphoserine at position 780. Contains a phosphoserine at position 742. Contains a phosphoserine at position 771. {ECO 0000244|PubMed 18669648, ECO 0000244|PubMed 19690332, ECO 0000244|PubMed 20068231, ECO 0000244|PubMed 21406692}; Name=6; Synonyms=NBCn1-G; IsoId=Q9Y6M7-6; Sequence=VSP_047840, VSP_047844, VSP_047848; Note=Contains a phosphoserine at position 263. Contains a phosphoserine at position 1105. Contains a phosphoserine at position 1111. Contains a phosphoserine at position 1073. Contains a phosphoserine at position 260. Contains a phosphoserine at position 1102. {ECO 0000244|PubMed 18669648, ECO 0000244|PubMed 19690332, ECO 0000244|PubMed 20068231, ECO 0000244|PubMed 21406692}; Name=7; Synonyms=NBCn1-D; IsoId=Q9Y6M7-7; Sequence=VSP_047841, VSP_047848; Note=Contains a phosphoserine at position 1233. Contains a phosphoserine at position 1239. Contains a phosphoserine at position 1201. Contains a phosphoserine at position 1230. {ECO 0000244|PubMed 18669648, ECO 0000244|PubMed 19690332, ECO 0000244|PubMed 20068231, ECO 0000244|PubMed 21406692}; Name=8; Synonyms=NBCn1-C; IsoId=Q9Y6M7-8; Sequence=VSP_047841, VSP_047843, VSP_047848; Note=Contains a phosphoserine at position 1220. Contains a phosphoserine at position 1226. Contains a phosphoserine at position 1188. Contains a phosphoserine at position 1217. {ECO 0000244|PubMed 18669648, ECO 0000244|PubMed 19690332, ECO 0000244|PubMed 20068231, ECO 0000244|PubMed 21406692}; Name=9; Synonyms=NBCn1-E; IsoId=Q9Y6M7-9; Sequence=VSP_047840, VSP_047844; Note=Contains a phosphoserine at position 263. Contains a phosphoserine at position 260. {ECO 0000244|PubMed 18669648, ECO 0000244|PubMed 19690332, ECO 0000244|PubMed 20068231, ECO 0000244|PubMed 21406692}; Name=10; IsoId=Q9Y6M7-10; Sequence=VSP_047840, VSP_047843, VSP_047846, VSP_047847; Name=11; IsoId=Q9Y6M7-11; Sequence=VSP_047840, VSP_047844, VSP_047846, VSP_047847; Note=Contains a phosphoserine at position 263. Contains a phosphoserine at position 260. {ECO 0000244|PubMed 18669648, ECO 0000244|PubMed 19690332, ECO 0000244|PubMed 20068231, ECO 0000244|PubMed 21406692}; Name=12; Synonyms=NBCn1-H; IsoId=Q9Y6M7-12; Sequence=VSP_047840, VSP_047843; Name=13; IsoId=Q9Y6M7-13; Sequence=VSP_047841, VSP_047844, VSP_047848; Note=Contains a phosphoserine at position 267. Contains a phosphoserine at position 1109. Contains a phosphoserine at position 1115. Contains a phosphoserine at position 1077. Contains a phosphoserine at position 264. Contains a phosphoserine at position 1106. {ECO 0000244|PubMed 18669648, ECO 0000244|PubMed 19690332, ECO 0000244|PubMed 20068231, ECO 0000244|PubMed 21406692}; Name=14; IsoId=Q9Y6M7-14; Sequence=VSP_047841, VSP_047844, VSP_047846, VSP_047847; Note=Contains a phosphoserine at position 267. Contains a phosphoserine at position 264. {ECO 0000244|PubMed 18669648, ECO 0000244|PubMed 19690332, ECO 0000244|PubMed 20068231, ECO 0000244|PubMed 21406692}; 
# AltName	S4A7_HUMAN	Electroneutral Na/HCO(3) cotransporter
# AltName	S4A7_HUMAN	Sodium bicarbonate cotransporter 2
# AltName	S4A7_HUMAN	Sodium bicarbonate cotransporter 2b
# AltName	S4A7_HUMAN	Solute carrier family 4 member 7
# BIOPHYSICOCHEMICAL PROPERTIES	Kinetic parameters: KM=24 mM for external sodium {ECO	0000269|PubMed:10347222}; 
# BioGrid	114876	28
# CCDS	CCDS33721	-. [Q9Y6M7-1]
# CCDS	CCDS58819	-. [Q9Y6M7-2]
# CCDS	CCDS58820	-. [Q9Y6M7-6]
# CCDS	CCDS82747	-. [Q9Y6M7-7]
# CCDS	CCDS82749	-. [Q9Y6M7-8]
# CCDS	CCDS82750	-. [Q9Y6M7-9]
# CCDS	CCDS82751	-. [Q9Y6M7-12]
# ChiTaRS	SLC4A7	human
# DOMAIN	S4A7_HUMAN	The PDZ-binding motif mediates interaction with the CFTR, SLC9A3R1/EBP50 complex and probably with USH1C. {ECO 0000269|PubMed 12403779}. 
# DrugBank	DB01390	Sodium bicarbonate
# ENZYME REGULATION	Transporter activity is regulated by CA2/carbonic anhydrase 2, cAMP and PKA. Insensitive to stilbene derivatives. PubMed	10347222 states it is inhibited by 5-(N-ethyl- N-isopropyl)-amiloride (EIPA). 
# Ensembl	ENST00000295736	ENSP00000295736; ENSG00000033867. [Q9Y6M7-1]
# Ensembl	ENST00000428386	ENSP00000416368; ENSG00000033867. [Q9Y6M7-2]
# Ensembl	ENST00000437179	ENSP00000394252; ENSG00000033867. [Q9Y6M7-9]
# Ensembl	ENST00000437266	ENSP00000409418; ENSG00000033867. [Q9Y6M7-11]
# Ensembl	ENST00000438530	ENSP00000407304; ENSG00000033867. [Q9Y6M7-10]
# Ensembl	ENST00000440156	ENSP00000414797; ENSG00000033867. [Q9Y6M7-8]
# Ensembl	ENST00000446700	ENSP00000406605; ENSG00000033867. [Q9Y6M7-12]
# Ensembl	ENST00000454389	ENSP00000390394; ENSG00000033867. [Q9Y6M7-7]
# Ensembl	ENST00000455077	ENSP00000407382; ENSG00000033867. [Q9Y6M7-6]
# Ensembl	ENST00000457377	ENSP00000408323; ENSG00000033867. [Q9Y6M7-11]
# ExpressionAtlas	Q9Y6M7	baseline and differential
# FUNCTION	S4A7_HUMAN	Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+) HCO3(-) 1 1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity. {ECO 0000269|PubMed 10347222, ECO 0000269|PubMed 12403779}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016324	apical plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0031410	cytoplasmic vesicle; IEA:Ensembl.
# GO_component	GO:0032420	stereocilium; IEA:UniProtKB-SubCell.
# GO_component	GO:0045202	synapse; IEA:Ensembl.
# GO_function	GO:0005452	inorganic anion exchanger activity; IEA:InterPro.
# GO_function	GO:0008509	anion transmembrane transporter activity; IBA:GO_Central.
# GO_function	S4A7_HUMAN	GO 0008510 sodium bicarbonate symporter activity; NAS UniProtKB.
# GO_process	GO:0015701	bicarbonate transport; NAS:UniProtKB.
# GO_process	GO:0051453	regulation of intracellular pH; IBA:GO_Central.
# GO_process	GO:0060117	auditory receptor cell development; IBA:GO_Central.
# GO_process	GO:0098656	anion transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.1100.10	-; 2.
# Genevisible	Q9Y6M7	HS
# HGNC	HGNC:11033	SLC4A7
# IntAct	Q9Y6M7	6
# InterPro	IPR003020	HCO3_transpt_euk
# InterPro	IPR011531	HCO3_transpt_C
# InterPro	IPR013769	Band3_cytoplasmic_dom
# InterPro	IPR016152	PTrfase/Anion_transptr
# KEGG_Brite	ko02001	Solute carrier family
# MIM	603353	gene
# Organism	S4A7_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11453	PTHR11453; 2
# PIR	JE0160	JE0160
# PRINTS	PR01231	HCO3TRNSPORT
# Pfam	PF00955	HCO3_cotransp
# Pfam	PF07565	Band_3_cyto
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-425381	Bicarbonate transporters
# RecName	S4A7_HUMAN	Sodium bicarbonate cotransporter 3
# RefSeq	NP_001245308	NM_001258379.1. [Q9Y6M7-6]
# RefSeq	NP_001245309	NM_001258380.1. [Q9Y6M7-2]
# RefSeq	NP_001308032	NM_001321103.1. [Q9Y6M7-7]
# RefSeq	NP_001308033	NM_001321104.1. [Q9Y6M7-8]
# RefSeq	NP_001308034	NM_001321105.1
# RefSeq	NP_001308035	NM_001321106.1. [Q9Y6M7-12]
# RefSeq	NP_001308036	NM_001321107.1. [Q9Y6M7-9]
# RefSeq	NP_001308037	NM_001321108.1. [Q9Y6M7-13]
# RefSeq	NP_003606	NM_003615.4. [Q9Y6M7-1]
# RefSeq	XP_016863017	XM_017007528.1. [Q9Y6M7-5]
# RefSeq	XP_016863018	XM_017007529.1. [Q9Y6M7-5]
# SIMILARITY	Belongs to the anion exchanger (TC 2.A.31) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S4A7_HUMAN	Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Cell projection, stereocilium {ECO 0000250}. Note=Also described at the apical cell membrane. Localizes to the stereocilia of cochlear outer hair cells and to the lateral membrane of cochlear inner hair cells (By similarity). {ECO 0000250}. 
# SUBUNIT	S4A7_HUMAN	Interacts with CFTR through SLC9A3R1/EBP50. Interacts with USH1C. Forms a complex with ATP6V1B1 and SLC9A3R1/EBP50. Interacts in a pH dependent-manner with CA2/carbonic anhydrase 2. {ECO 0000269|PubMed 12403779, ECO 0000269|PubMed 12444018, ECO 0000269|PubMed 14736710, ECO 0000269|PubMed 16301216}. 
# SUPFAM	SSF55804	SSF55804; 2
# TCDB	2.A.31.2.11	the anion exchanger (ae) family
# TIGRFAMs	TIGR00834	ae
# TISSUE SPECIFICITY	Highly expressed in testis and spleen. Also expressed in retina, colon, small intestine, ovary, thymus, prostate, muscle, heart and kidney. Isoform 1 is expressed in skeletal muscle and heart muscle. {ECO:0000269|PubMed	9610397}. 
# UCSC	uc003cdu	human. [Q9Y6M7-1]
# eggNOG	ENOG410XPHD	LUCA
# eggNOG	KOG1172	Eukaryota
BLAST	swissprot:S4A7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S4A7_HUMAN
COXPRESdb	9497	http://coxpresdb.jp/data/gene/9497.shtml
CleanEx	HS_SLC4A7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC4A7
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/bbrc.1998.8658	http://dx.doi.org/10.1006/bbrc.1998.8658
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1021/ac035352d	http://dx.doi.org/10.1021/ac035352d
DOI	10.1021/pr0705441	http://dx.doi.org/10.1021/pr0705441
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1038/nbt.1532	http://dx.doi.org/10.1038/nbt.1532
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/jbc.274.23.16569	http://dx.doi.org/10.1074/jbc.274.23.16569
DOI	10.1074/jbc.M201862200	http://dx.doi.org/10.1074/jbc.M201862200
DOI	10.1093/hmg/ddi417	http://dx.doi.org/10.1093/hmg/ddi417
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1152/ajpcell.00225.2002	http://dx.doi.org/10.1152/ajpcell.00225.2002
DOI	10.1152/ajpcell.00382.2003	http://dx.doi.org/10.1152/ajpcell.00382.2003
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.1242/jeb.028563	http://dx.doi.org/10.1242/jeb.028563
DrugBank	DB01390	http://www.drugbank.ca/drugs/DB01390
EMBL	AB012130	http://www.ebi.ac.uk/ena/data/view/AB012130
EMBL	AC099535	http://www.ebi.ac.uk/ena/data/view/AC099535
EMBL	AF047033	http://www.ebi.ac.uk/ena/data/view/AF047033
EMBL	AF053755	http://www.ebi.ac.uk/ena/data/view/AF053755
EMBL	AF089726	http://www.ebi.ac.uk/ena/data/view/AF089726
EMBL	CH471055	http://www.ebi.ac.uk/ena/data/view/CH471055
EMBL	CR627428	http://www.ebi.ac.uk/ena/data/view/CR627428
EMBL	EU499349	http://www.ebi.ac.uk/ena/data/view/EU499349
EMBL	EU934246	http://www.ebi.ac.uk/ena/data/view/EU934246
EMBL	EU934248	http://www.ebi.ac.uk/ena/data/view/EU934248
EMBL	EU934249	http://www.ebi.ac.uk/ena/data/view/EU934249
EMBL	EU934250	http://www.ebi.ac.uk/ena/data/view/EU934250
EMBL	FJ178574	http://www.ebi.ac.uk/ena/data/view/FJ178574
EMBL	FJ178575	http://www.ebi.ac.uk/ena/data/view/FJ178575
EMBL	FJ178576	http://www.ebi.ac.uk/ena/data/view/FJ178576
EMBL	GU354307	http://www.ebi.ac.uk/ena/data/view/GU354307
EMBL	GU354308	http://www.ebi.ac.uk/ena/data/view/GU354308
EMBL	GU354309	http://www.ebi.ac.uk/ena/data/view/GU354309
EMBL	GU354310	http://www.ebi.ac.uk/ena/data/view/GU354310
Ensembl	ENST00000295736	http://www.ensembl.org/id/ENST00000295736
Ensembl	ENST00000428386	http://www.ensembl.org/id/ENST00000428386
Ensembl	ENST00000437179	http://www.ensembl.org/id/ENST00000437179
Ensembl	ENST00000437266	http://www.ensembl.org/id/ENST00000437266
Ensembl	ENST00000438530	http://www.ensembl.org/id/ENST00000438530
Ensembl	ENST00000440156	http://www.ensembl.org/id/ENST00000440156
Ensembl	ENST00000446700	http://www.ensembl.org/id/ENST00000446700
Ensembl	ENST00000454389	http://www.ensembl.org/id/ENST00000454389
Ensembl	ENST00000455077	http://www.ensembl.org/id/ENST00000455077
Ensembl	ENST00000457377	http://www.ensembl.org/id/ENST00000457377
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GO_component	GO:0032420	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032420
GO_component	GO:0045202	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045202
GO_function	GO:0005452	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005452
GO_function	GO:0008509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008509
GO_function	GO:0008510	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008510
GO_process	GO:0015701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015701
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GO_process	GO:0060117	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060117
GO_process	GO:0098656	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098656
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.1100.10	http://www.cathdb.info/version/latest/superfamily/3.40.1100.10
GeneCards	SLC4A7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC4A7
GeneID	9497	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9497
GeneTree	ENSGT00760000119021	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119021
HGNC	HGNC:11033	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11033
HOGENOM	HOG000280684	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280684&db=HOGENOM6
HOVERGEN	HBG004326	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004326&db=HOVERGEN
HPA	CAB022494	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB022494
HPA	HPA035857	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035857
InParanoid	Q9Y6M7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y6M7
IntAct	Q9Y6M7	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9Y6M7*
InterPro	IPR003020	http://www.ebi.ac.uk/interpro/entry/IPR003020
InterPro	IPR011531	http://www.ebi.ac.uk/interpro/entry/IPR011531
InterPro	IPR013769	http://www.ebi.ac.uk/interpro/entry/IPR013769
InterPro	IPR016152	http://www.ebi.ac.uk/interpro/entry/IPR016152
Jabion	9497	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9497
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:9497	http://www.genome.jp/dbget-bin/www_bget?hsa:9497
KEGG_Orthology	KO:K13858	http://www.genome.jp/dbget-bin/www_bget?KO:K13858
MIM	603353	http://www.ncbi.nlm.nih.gov/omim/603353
MINT	MINT-1632023	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1632023
OMA	ETYAFNM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ETYAFNM
OrthoDB	EOG091G01FT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01FT
PANTHER	PTHR11453	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11453
PRINTS	PR01231	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01231
PSORT	swissprot:S4A7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S4A7_HUMAN
PSORT-B	swissprot:S4A7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S4A7_HUMAN
PSORT2	swissprot:S4A7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S4A7_HUMAN
Pfam	PF00955	http://pfam.xfam.org/family/PF00955
Pfam	PF07565	http://pfam.xfam.org/family/PF07565
PharmGKB	PA35899	http://www.pharmgkb.org/do/serve?objId=PA35899&objCls=Gene
Phobius	swissprot:S4A7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S4A7_HUMAN
PhylomeDB	Q9Y6M7	http://phylomedb.org/?seqid=Q9Y6M7
ProteinModelPortal	Q9Y6M7	http://www.proteinmodelportal.org/query/uniprot/Q9Y6M7
PubMed	10347222	http://www.ncbi.nlm.nih.gov/pubmed/10347222
PubMed	12403779	http://www.ncbi.nlm.nih.gov/pubmed/12403779
PubMed	12444018	http://www.ncbi.nlm.nih.gov/pubmed/12444018
PubMed	14736710	http://www.ncbi.nlm.nih.gov/pubmed/14736710
PubMed	15144186	http://www.ncbi.nlm.nih.gov/pubmed/15144186
PubMed	16301216	http://www.ncbi.nlm.nih.gov/pubmed/16301216
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18220336	http://www.ncbi.nlm.nih.gov/pubmed/18220336
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19349973	http://www.ncbi.nlm.nih.gov/pubmed/19349973
PubMed	19448079	http://www.ncbi.nlm.nih.gov/pubmed/19448079
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	9610397	http://www.ncbi.nlm.nih.gov/pubmed/9610397
Reactome	R-HSA-425381	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425381
RefSeq	NP_001245308	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001245308
RefSeq	NP_001245309	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001245309
RefSeq	NP_001308032	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001308032
RefSeq	NP_001308033	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001308033
RefSeq	NP_001308034	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001308034
RefSeq	NP_001308035	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001308035
RefSeq	NP_001308036	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001308036
RefSeq	NP_001308037	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001308037
RefSeq	NP_003606	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003606
RefSeq	XP_016863017	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016863017
RefSeq	XP_016863018	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016863018
STRING	9606.ENSP00000295736	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000295736&targetmode=cogs
SUPFAM	SSF55804	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55804
TCDB	2.A.31.2.11	http://www.tcdb.org/search/result.php?tc=2.A.31.2.11
TIGRFAMs	TIGR00834	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00834
UCSC	uc003cdu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003cdu&org=rat
UniGene	Hs.250072	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.250072
UniProtKB	S4A7_HUMAN	http://www.uniprot.org/uniprot/S4A7_HUMAN
UniProtKB-AC	Q9Y6M7	http://www.uniprot.org/uniprot/Q9Y6M7
charge	swissprot:S4A7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S4A7_HUMAN
eggNOG	ENOG410XPHD	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPHD
eggNOG	KOG1172	http://eggnogapi.embl.de/nog_data/html/tree/KOG1172
epestfind	swissprot:S4A7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S4A7_HUMAN
garnier	swissprot:S4A7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S4A7_HUMAN
helixturnhelix	swissprot:S4A7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S4A7_HUMAN
hmoment	swissprot:S4A7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S4A7_HUMAN
iep	swissprot:S4A7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S4A7_HUMAN
inforesidue	swissprot:S4A7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S4A7_HUMAN
neXtProt	NX_Q9Y6M7	http://www.nextprot.org/db/entry/NX_Q9Y6M7
octanol	swissprot:S4A7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S4A7_HUMAN
pepcoil	swissprot:S4A7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S4A7_HUMAN
pepdigest	swissprot:S4A7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S4A7_HUMAN
pepinfo	swissprot:S4A7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S4A7_HUMAN
pepnet	swissprot:S4A7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S4A7_HUMAN
pepstats	swissprot:S4A7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S4A7_HUMAN
pepwheel	swissprot:S4A7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S4A7_HUMAN
pepwindow	swissprot:S4A7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S4A7_HUMAN
sigcleave	swissprot:S4A7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S4A7_HUMAN
## Database	ID	URL or Descriptions
# DOMAIN	AQ12A_HUMAN	Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). 
# Ensembl	ENST00000337801	ENSP00000337144; ENSG00000184945
# ExpressionAtlas	Q8IXF9	baseline and differential
# FUNCTION	AQ12A_HUMAN	Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015250	water channel activity; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# Gene3D	1.20.1080.10	-; 1.
# Genevisible	Q8IXF9	HS
# HGNC	HGNC:19941	AQP12A
# InterPro	IPR000425	MIP
# InterPro	IPR016697	Aquaporin_11/12
# InterPro	IPR023265	Aquaporin_12
# InterPro	IPR023271	Aquaporin-like
# KEGG_Brite	ko04040	Ion channels
# MIM	609789	gene
# Organism	AQ12A_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR21191:SF8	PTHR21191:SF8
# PIRSF	PIRSF017529	Aquaporin_11/12
# PRINTS	PR00783	MINTRINSICP
# PRINTS	PR02025	AQUAPORIN12
# Pfam	PF00230	MIP
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-432047	Passive transport by Aquaporins
# RecName	AQ12A_HUMAN	Aquaporin-12A
# RefSeq	NP_945349	NM_198998.2
# SIMILARITY	Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	AQ12A_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF81338	SSF81338
# TCDB	1.A.8.17	the major intrinsic protein (mip) family
# TISSUE SPECIFICITY	Restricted to the pancreas. {ECO	0000269|Ref.2}. 
# UCSC	uc002vzu	human
# eggNOG	ENOG410IJA3	Eukaryota
# eggNOG	ENOG4111GCP	LUCA
BLAST	swissprot:AQ12A_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AQ12A_HUMAN
BioCyc	ZFISH:G66-32288-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32288-MONOMER
COXPRESdb	375318	http://coxpresdb.jp/data/gene/375318.shtml
CleanEx	HS_AQP12A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AQP12A
DOI	10.1016/j.bbrc.2005.03.046	http://dx.doi.org/10.1016/j.bbrc.2005.03.046
EMBL	AB040748	http://www.ebi.ac.uk/ena/data/view/AB040748
Ensembl	ENST00000337801	http://www.ensembl.org/id/ENST00000337801
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015250	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015250
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
Gene3D	1.20.1080.10	http://www.cathdb.info/version/latest/superfamily/1.20.1080.10
GeneCards	AQP12A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=AQP12A
GeneID	375318	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=375318
GeneTree	ENSGT00530000063816	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063816
H-InvDB	HIX0024040	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0024040
HGNC	HGNC:19941	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:19941
HOGENOM	HOG000034023	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000034023&db=HOGENOM6
HOVERGEN	HBG050557	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050557&db=HOVERGEN
HPA	HPA042216	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042216
InParanoid	Q8IXF9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8IXF9
InterPro	IPR000425	http://www.ebi.ac.uk/interpro/entry/IPR000425
InterPro	IPR016697	http://www.ebi.ac.uk/interpro/entry/IPR016697
InterPro	IPR023265	http://www.ebi.ac.uk/interpro/entry/IPR023265
InterPro	IPR023271	http://www.ebi.ac.uk/interpro/entry/IPR023271
Jabion	375318	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=375318
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:375318	http://www.genome.jp/dbget-bin/www_bget?hsa:375318
KEGG_Orthology	KO:K09871	http://www.genome.jp/dbget-bin/www_bget?KO:K09871
MIM	609789	http://www.ncbi.nlm.nih.gov/omim/609789
PANTHER	PTHR21191:SF8	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21191:SF8
PRINTS	PR00783	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00783
PRINTS	PR02025	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR02025
PSORT	swissprot:AQ12A_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AQ12A_HUMAN
PSORT-B	swissprot:AQ12A_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AQ12A_HUMAN
PSORT2	swissprot:AQ12A_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AQ12A_HUMAN
Pfam	PF00230	http://pfam.xfam.org/family/PF00230
PharmGKB	PA134977417	http://www.pharmgkb.org/do/serve?objId=PA134977417&objCls=Gene
Phobius	swissprot:AQ12A_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AQ12A_HUMAN
PhylomeDB	Q8IXF9	http://phylomedb.org/?seqid=Q8IXF9
ProteinModelPortal	Q8IXF9	http://www.proteinmodelportal.org/query/uniprot/Q8IXF9
PubMed	15809071	http://www.ncbi.nlm.nih.gov/pubmed/15809071
Reactome	R-HSA-432047	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432047
RefSeq	NP_945349	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_945349
STRING	9606.ENSP00000337144	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000337144&targetmode=cogs
SUPFAM	SSF81338	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81338
TCDB	1.A.8.17	http://www.tcdb.org/search/result.php?tc=1.A.8.17
UCSC	uc002vzu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002vzu&org=rat
UniGene	Hs.534650	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.534650
UniProtKB	AQ12A_HUMAN	http://www.uniprot.org/uniprot/AQ12A_HUMAN
UniProtKB-AC	Q8IXF9	http://www.uniprot.org/uniprot/Q8IXF9
charge	swissprot:AQ12A_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AQ12A_HUMAN
eggNOG	ENOG410IJA3	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IJA3
eggNOG	ENOG4111GCP	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111GCP
epestfind	swissprot:AQ12A_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AQ12A_HUMAN
garnier	swissprot:AQ12A_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AQ12A_HUMAN
helixturnhelix	swissprot:AQ12A_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AQ12A_HUMAN
hmoment	swissprot:AQ12A_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AQ12A_HUMAN
iep	swissprot:AQ12A_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AQ12A_HUMAN
inforesidue	swissprot:AQ12A_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AQ12A_HUMAN
neXtProt	NX_Q8IXF9	http://www.nextprot.org/db/entry/NX_Q8IXF9
octanol	swissprot:AQ12A_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AQ12A_HUMAN
pepcoil	swissprot:AQ12A_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AQ12A_HUMAN
pepdigest	swissprot:AQ12A_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AQ12A_HUMAN
pepinfo	swissprot:AQ12A_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AQ12A_HUMAN
pepnet	swissprot:AQ12A_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AQ12A_HUMAN
pepstats	swissprot:AQ12A_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AQ12A_HUMAN
pepwheel	swissprot:AQ12A_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AQ12A_HUMAN
pepwindow	swissprot:AQ12A_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AQ12A_HUMAN
sigcleave	swissprot:AQ12A_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AQ12A_HUMAN
## Database	ID	URL or Descriptions
# AltName	CLCA1_HUMAN	Calcium-activated chloride channel family member 1
# AltName	CLCA1_HUMAN	Calcium-activated chloride channel protein 1
# BioGrid	107593	2
# DOMAIN	CLCA1_HUMAN	The metalloprotease region is responsible for autoproteolytic processing. It can also cross-cleave other CLCA Substrates. {ECO 0000269|PubMed 23112050}. 
# Ensembl	ENST00000234701	ENSP00000234701; ENSG00000016490
# Ensembl	ENST00000394711	ENSP00000378200; ENSG00000016490
# FUNCTION	CLCA1_HUMAN	May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. {ECO 0000269|PubMed 11445004, ECO 0000269|PubMed 11842292, ECO 0000269|PubMed 11956057, ECO 0000269|PubMed 23112050, ECO 0000269|PubMed 9828122}. 
# GO_component	GO:0005615	extracellular space; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0005902	microvillus; IEA:Ensembl.
# GO_component	GO:0042589	zymogen granule membrane; IEA:Ensembl.
# GO_function	GO:0004222	metalloendopeptidase activity; TAS:Reactome.
# GO_function	GO:0005229	intracellular calcium activated chloride channel activity; IEA:InterPro.
# GO_function	GO:0005254	chloride channel activity; TAS:ProtInc.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006816	calcium ion transport; IEA:UniProtKB-KW.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0071456	cellular response to hypoxia; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005615	extracellular space
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0008233	peptidase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.410	-; 1.
# Genevisible	A8K7I4	HS
# HGNC	HGNC:2015	CLCA1
# INDUCTION	CLCA1_HUMAN	By IL13/interleukin-13 in tracheobronchial epithelial cells. Up-regulated by histamine in a dose-dependent manner. Significantly down-regulated in colorectal cancer. Significantly up-regulated in the IL9-responsive mucus-producing epithelium of asthmatic patients. Significantly decreased in nasal polyp. Significantly increased by TNF in upper airway mucosa. {ECO 0000269|PubMed 11445004, ECO 0000269|PubMed 11842292, ECO 0000269|PubMed 11956057, ECO 0000269|PubMed 15696080, ECO 0000269|PubMed 16012037, ECO 0000269|PubMed 16151054, ECO 0000269|PubMed 17622767}. 
# InterPro	IPR002035	VWF_A
# InterPro	IPR004727	CLCA_chordata
# InterPro	IPR013642	CLCA
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04740	Olfactory transduction
# KEGG_Pathway	ko04972	Pancreatic secretion
# MIM	603906	gene
# Organism	CLCA1_HUMAN	Homo sapiens (Human)
# PROSITE	PS50234	VWFA
# PTM	CLCA1_HUMAN	Glycosylated. {ECO 0000269|PubMed 9828122}. 
# PTM	CLCA1_HUMAN	The 125-kDa product is autoproteolytically processed by the metalloprotease domain and yields to two cell-surface-associated subunits, a 90-kDa protein and a group of 37-to 41-kDa proteins. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity. {ECO 0000269|PubMed 23112050, ECO 0000269|PubMed 9828122}. 
# Pfam	PF08434	CLCA
# Pfam	PF13519	VWA_2
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	CLCA1_HUMAN	Calcium-activated chloride channel regulator 1
# RefSeq	NP_001276	NM_001285.3
# SIMILARITY	Belongs to the CLCR family. {ECO	0000305}. 
# SIMILARITY	Contains 1 VWFA domain. {ECO:0000255|PROSITE- ProRule	PRU00219}.
# SMART	SM00327	VWA
# SUBCELLULAR LOCATION	CLCA1_HUMAN	Secreted, extracellular space {ECO 0000269|PubMed 15919655}. Cell membrane {ECO 0000269|PubMed 15919655}; Peripheral membrane protein {ECO 0000269|PubMed 15919655}; Extracellular side {ECO 0000269|PubMed 15919655}. Note=Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli. 
# SUPFAM	SSF53300	SSF53300
# TCDB	1.A.13.1	the epithelial chloride channel (e-clc) family
# TIGRFAMs	TIGR00868	hCaCC
# TISSUE SPECIFICITY	CLCA1_HUMAN	Highly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both asthmatic and healthy patients. Expressed in the bronchial epithelium, especially in mucus- producing goblet cells. Expressed in normal turbinate mucosa and nasal polyp. Expressed in. {ECO 0000269|PubMed 10437792, ECO 0000269|PubMed 11842292, ECO 0000269|PubMed 11956057, ECO 0000269|PubMed 16012037, ECO 0000269|PubMed 9828122}. 
# UCSC	uc001dlt	human
# eggNOG	ENOG410IEPS	Eukaryota
# eggNOG	ENOG410XPSZ	LUCA
BLAST	swissprot:CLCA1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CLCA1_HUMAN
COXPRESdb	1179	http://coxpresdb.jp/data/gene/1179.shtml
CleanEx	HS_CLCA1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CLCA1
DOI	10.1006/geno.1998.5562	http://dx.doi.org/10.1006/geno.1998.5562
DOI	10.1016/S0014-5793(99)00891-1	http://dx.doi.org/10.1016/S0014-5793(99)00891-1
DOI	10.1016/j.jaci.2004.09.039	http://dx.doi.org/10.1016/j.jaci.2004.09.039
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1067/mai.2002.121555	http://dx.doi.org/10.1067/mai.2002.121555
DOI	10.1074/jbc.M112.410282	http://dx.doi.org/10.1074/jbc.M112.410282
DOI	10.1074/jbc.M504654200	http://dx.doi.org/10.1074/jbc.M504654200
DOI	10.1080/00016480510028519	http://dx.doi.org/10.1080/00016480510028519
DOI	10.1089/10445490152122442	http://dx.doi.org/10.1089/10445490152122442
DOI	10.1159/000104419	http://dx.doi.org/10.1159/000104419
DOI	10.1164/ajrccm.165.8.2107068	http://dx.doi.org/10.1164/ajrccm.165.8.2107068
DOI	10.1165/rcmb.2004-0220RC	http://dx.doi.org/10.1165/rcmb.2004-0220RC
EC_number	EC:3.4.-.- {ECO:0000269|PubMed:23112050}	http://www.genome.jp/dbget-bin/www_bget?EC:3.4.-.- {ECO:0000269|PubMed:23112050}
EMBL	AF039400	http://www.ebi.ac.uk/ena/data/view/AF039400
EMBL	AF039401	http://www.ebi.ac.uk/ena/data/view/AF039401
EMBL	AF127036	http://www.ebi.ac.uk/ena/data/view/AF127036
EMBL	AK291999	http://www.ebi.ac.uk/ena/data/view/AK291999
EMBL	AK314375	http://www.ebi.ac.uk/ena/data/view/AK314375
EMBL	AL122002	http://www.ebi.ac.uk/ena/data/view/AL122002
EMBL	CH471097	http://www.ebi.ac.uk/ena/data/view/CH471097
ENZYME	3.4.-.- {ECO:0000269|PubMed:23112050}	http://enzyme.expasy.org/EC/3.4.-.- {ECO:0000269|PubMed:23112050}
Ensembl	ENST00000234701	http://www.ensembl.org/id/ENST00000234701
Ensembl	ENST00000394711	http://www.ensembl.org/id/ENST00000394711
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005615
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005902
GO_component	GO:0042589	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042589
GO_function	GO:0004222	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004222
GO_function	GO:0005229	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005229
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0071456	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071456
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005615
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0008233	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.410	http://www.cathdb.info/version/latest/superfamily/3.40.50.410
GeneCards	CLCA1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CLCA1
GeneID	1179	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1179
GeneTree	ENSGT00390000004810	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000004810
HGNC	HGNC:2015	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2015
HOGENOM	HOG000015107	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000015107&db=HOGENOM6
HOVERGEN	HBG005560	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG005560&db=HOVERGEN
HPA	HPA052787	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA052787
HPA	HPA059301	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA059301
InParanoid	A8K7I4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=A8K7I4
IntAct	A8K7I4	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=A8K7I4*
IntEnz	3.4.-.- {ECO:0000269|PubMed:23112050}	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.-.- {ECO:0000269|PubMed:23112050}
InterPro	IPR002035	http://www.ebi.ac.uk/interpro/entry/IPR002035
InterPro	IPR004727	http://www.ebi.ac.uk/interpro/entry/IPR004727
InterPro	IPR013642	http://www.ebi.ac.uk/interpro/entry/IPR013642
Jabion	1179	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1179
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:1179	http://www.genome.jp/dbget-bin/www_bget?hsa:1179
KEGG_Orthology	KO:K05027	http://www.genome.jp/dbget-bin/www_bget?KO:K05027
KEGG_Pathway	ko04740	http://www.genome.jp/kegg-bin/show_pathway?ko04740
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
MIM	603906	http://www.ncbi.nlm.nih.gov/omim/603906
OMA	KNTKMAY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KNTKMAY
OrthoDB	EOG091G09E6	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G09E6
PROSITE	PS50234	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50234
PSORT	swissprot:CLCA1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CLCA1_HUMAN
PSORT-B	swissprot:CLCA1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CLCA1_HUMAN
PSORT2	swissprot:CLCA1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CLCA1_HUMAN
Pfam	PF08434	http://pfam.xfam.org/family/PF08434
Pfam	PF13519	http://pfam.xfam.org/family/PF13519
PharmGKB	PA26542	http://www.pharmgkb.org/do/serve?objId=PA26542&objCls=Gene
Phobius	swissprot:CLCA1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CLCA1_HUMAN
PhylomeDB	A8K7I4	http://phylomedb.org/?seqid=A8K7I4
ProteinModelPortal	A8K7I4	http://www.proteinmodelportal.org/query/uniprot/A8K7I4
PubMed	10437792	http://www.ncbi.nlm.nih.gov/pubmed/10437792
PubMed	11445004	http://www.ncbi.nlm.nih.gov/pubmed/11445004
PubMed	11842292	http://www.ncbi.nlm.nih.gov/pubmed/11842292
PubMed	11956057	http://www.ncbi.nlm.nih.gov/pubmed/11956057
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15696080	http://www.ncbi.nlm.nih.gov/pubmed/15696080
PubMed	15919655	http://www.ncbi.nlm.nih.gov/pubmed/15919655
PubMed	16012037	http://www.ncbi.nlm.nih.gov/pubmed/16012037
PubMed	16151054	http://www.ncbi.nlm.nih.gov/pubmed/16151054
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17622767	http://www.ncbi.nlm.nih.gov/pubmed/17622767
PubMed	23112050	http://www.ncbi.nlm.nih.gov/pubmed/23112050
PubMed	9828122	http://www.ncbi.nlm.nih.gov/pubmed/9828122
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_001276	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001276
SMART	SM00327	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00327
SMR	A8K7I4	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=A8K7I4
STRING	9606.ENSP00000234701	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000234701&targetmode=cogs
SUPFAM	SSF53300	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53300
TCDB	1.A.13.1	http://www.tcdb.org/search/result.php?tc=1.A.13.1
TIGRFAMs	TIGR00868	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00868
UCSC	uc001dlt	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001dlt&org=rat
UniGene	Hs.194659	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.194659
UniProtKB	CLCA1_HUMAN	http://www.uniprot.org/uniprot/CLCA1_HUMAN
UniProtKB-AC	A8K7I4	http://www.uniprot.org/uniprot/A8K7I4
charge	swissprot:CLCA1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CLCA1_HUMAN
eggNOG	ENOG410IEPS	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IEPS
eggNOG	ENOG410XPSZ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPSZ
epestfind	swissprot:CLCA1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CLCA1_HUMAN
garnier	swissprot:CLCA1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CLCA1_HUMAN
helixturnhelix	swissprot:CLCA1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLCA1_HUMAN
hmoment	swissprot:CLCA1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CLCA1_HUMAN
iep	swissprot:CLCA1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CLCA1_HUMAN
inforesidue	swissprot:CLCA1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CLCA1_HUMAN
neXtProt	NX_A8K7I4	http://www.nextprot.org/db/entry/NX_A8K7I4
octanol	swissprot:CLCA1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CLCA1_HUMAN
pepcoil	swissprot:CLCA1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CLCA1_HUMAN
pepdigest	swissprot:CLCA1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CLCA1_HUMAN
pepinfo	swissprot:CLCA1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CLCA1_HUMAN
pepnet	swissprot:CLCA1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CLCA1_HUMAN
pepstats	swissprot:CLCA1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CLCA1_HUMAN
pepwheel	swissprot:CLCA1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CLCA1_HUMAN
pepwindow	swissprot:CLCA1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CLCA1_HUMAN
sigcleave	swissprot:CLCA1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CLCA1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TNPO1_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q92973-1; Sequence=Displayed; Name=2; IsoId=Q92973-2; Sequence=VSP_038028; Note=Contains a N-acetylmethionine at position 1. {ECO 0000244|PubMed 19413330, ECO 0000244|PubMed 22223895}; Name=3; IsoId=Q92973-3; Sequence=VSP_038029; 
# AltName	TNPO1_HUMAN	Importin beta-2
# AltName	TNPO1_HUMAN	Karyopherin beta-2
# AltName	TNPO1_HUMAN	M9 region interaction protein
# BioGrid	110040	72
# CCDS	CCDS4016	-. [Q92973-2]
# CCDS	CCDS43329	-. [Q92973-1]
# ChiTaRS	TNPO1	human
# Ensembl	ENST00000337273	ENSP00000336712; ENSG00000083312. [Q92973-1]
# Ensembl	ENST00000506351	ENSP00000425118; ENSG00000083312. [Q92973-2]
# Ensembl	ENST00000523768	ENSP00000428899; ENSG00000083312. [Q92973-3]
# ExpressionAtlas	Q92973	baseline and differential
# FUNCTION	TNPO1_HUMAN	Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9- containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Mediates nuclear import of ADAR/ADAR1 (isoform 5) in a RanGTP-dependent manner. {ECO 0000250, ECO 0000269|PubMed 11682607, ECO 0000269|PubMed 19124606, ECO 0000269|PubMed 8986607, ECO 0000269|PubMed 9687515}. 
# GO_component	GO:0005634	nucleus; TAS:ProtInc.
# GO_component	GO:0005737	cytoplasm; TAS:ProtInc.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0031965	nuclear membrane; IBA:GO_Central.
# GO_component	GO:0034399	nuclear periphery; IBA:GO_Central.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0008139	nuclear localization sequence binding; TAS:ProtInc.
# GO_function	GO:0008565	protein transporter activity; IBA:GO_Central.
# GO_function	GO:0044822	poly(A) RNA binding; IDA:UniProtKB.
# GO_process	GO:0000059	protein import into nucleus, docking; IBA:GO_Central.
# GO_process	GO:0000060	protein import into nucleus, translocation; TAS:ProtInc.
# GO_process	GO:0006607	NLS-bearing protein import into nucleus; IBA:GO_Central.
# GO_process	GO:0006610	ribosomal protein import into nucleus; IBA:GO_Central.
# GO_process	GO:0016032	viral process; IEA:UniProtKB-KW.
# GO_process	GO:0043488	regulation of mRNA stability; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0003723	RNA binding
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# Gene3D	1.25.10.10	-; 2.
# Genevisible	Q92973	HS
# HGNC	HGNC:6401	TNPO1
# INTERACTION	TNPO1_HUMAN	P62993 GRB2; NbExp=2; IntAct=EBI-286693, EBI-401755; P62826 RAN; NbExp=2; IntAct=EBI-286693, EBI-286642; 
# IntAct	Q92973	39
# InterPro	IPR001494	Importin-beta_N
# InterPro	IPR011989	ARM-like
# InterPro	IPR016024	ARM-type_fold
# MIM	602901	gene
# Organism	TNPO1_HUMAN	Homo sapiens (Human)
# PDB	1QBK	X-ray; 3.00 A; B=9-898
# PDB	2H4M	X-ray; 3.05 A; A/B=376-898, A/B=9-343
# PDB	2OT8	X-ray; 3.10 A; A/B=9-331, A/B=375-898
# PDB	2QMR	X-ray; 3.00 A; A/B/C/D=9-898
# PDB	2Z5J	X-ray; 3.40 A; A=9-898
# PDB	2Z5K	X-ray; 2.60 A; A=9-898
# PDB	2Z5M	X-ray; 3.00 A; A=9-898
# PDB	2Z5N	X-ray; 3.20 A; A=9-898
# PDB	2Z5O	X-ray; 3.20 A; A=9-898
# PDB	4FDD	X-ray; 2.30 A; A=9-331, A=375-898
# PDB	4FQ3	X-ray; 3.00 A; A=9-898
# PDB	4JLQ	X-ray; 3.05 A; A=9-331, A=375-898
# PDB	4OO6	X-ray; 2.70 A; A=375-898, A=9-331
# PDB	5J3V	X-ray; 3.05 A; A/B=9-331, A/B=375-898
# PROSITE	PS50166	IMPORTIN_B_NT
# Pfam	PF03810	IBN_N
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-450513	Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
# Reactome	R-HSA-5620924	Intraflagellar transport
# RecName	TNPO1_HUMAN	Transportin-1
# RefSeq	NP_002261	NM_002270.3. [Q92973-1]
# RefSeq	NP_694858	NM_153188.2. [Q92973-2]
# RefSeq	XP_005248557	XM_005248500.2. [Q92973-2]
# SEQUENCE CAUTION	Sequence=AAC50723.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH40340.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the importin beta family. Importin beta-2 subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 importin N-terminal domain. {ECO:0000255|PROSITE-ProRule	PRU00115}. 
# SIMILARITY	Contains 20 HEAT repeats. {ECO:0000269|PubMed	10353245}. 
# SMART	SM00913	IBN_N
# SUBCELLULAR LOCATION	TNPO1_HUMAN	Cytoplasm. Nucleus. 
# SUBUNIT	TNPO1_HUMAN	Binds HNRPA1, HNRPA2, HNRNPDL, RPL23A, RPS7, RPL5, RAN and SRP19. Interacts with H2A, H2B, H3 and H4 histones. Binds to HIV-1 Rev. Interacts with isoform 5 of ADAR/ADAR1 (via DRBM 3 domain). Interacts with SNAI1 (via zinc fingers); the interaction mediates SNAI1 nuclear import. Interacts with SNAI2 (via zinc fingers). {ECO 0000269|PubMed 11682607, ECO 0000269|PubMed 16704975, ECO 0000269|PubMed 19124606, ECO 0000269|PubMed 19386897, ECO 0000269|PubMed 9524220, ECO 0000269|PubMed 9687515}. 
# SUPFAM	SSF48371	SSF48371
# TCDB	1.I.1.1	the nuclear pore complex (npc) family
# UCSC	uc003kci	human. [Q92973-1]
# eggNOG	ENOG410XPK2	LUCA
# eggNOG	KOG2023	Eukaryota
BLAST	swissprot:TNPO1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TNPO1_HUMAN
BioCyc	ZFISH:ENSG00000083312-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000083312-MONOMER
COXPRESdb	3842	http://coxpresdb.jp/data/gene/3842.shtml
CleanEx	HS_TNPO1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TNPO1
DIP	DIP-29335N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29335N
DOI	10.1006/excr.1996.0369	http://dx.doi.org/10.1006/excr.1996.0369
DOI	10.1016/S0092-8674(00)80173-7	http://dx.doi.org/10.1016/S0092-8674(00)80173-7
DOI	10.1016/S0167-4781(97)00223-6	http://dx.doi.org/10.1016/S0167-4781(97)00223-6
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1038/20375	http://dx.doi.org/10.1038/20375
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.94.10.5055	http://dx.doi.org/10.1073/pnas.94.10.5055
DOI	10.1074/jbc.M602189200	http://dx.doi.org/10.1074/jbc.M602189200
DOI	10.1074/mcp.M111.015131	http://dx.doi.org/10.1074/mcp.M111.015131
DOI	10.1093/emboj/17.15.4491	http://dx.doi.org/10.1093/emboj/17.15.4491
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1128/MCB.01519-08	http://dx.doi.org/10.1128/MCB.01519-08
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1242/jcs.041749	http://dx.doi.org/10.1242/jcs.041749
EMBL	AK301021	http://www.ebi.ac.uk/ena/data/view/AK301021
EMBL	BC040340	http://www.ebi.ac.uk/ena/data/view/BC040340
EMBL	U70322	http://www.ebi.ac.uk/ena/data/view/U70322
EMBL	U72069	http://www.ebi.ac.uk/ena/data/view/U72069
EMBL	U72395	http://www.ebi.ac.uk/ena/data/view/U72395
Ensembl	ENST00000337273	http://www.ensembl.org/id/ENST00000337273
Ensembl	ENST00000506351	http://www.ensembl.org/id/ENST00000506351
Ensembl	ENST00000523768	http://www.ensembl.org/id/ENST00000523768
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0031965	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031965
GO_component	GO:0034399	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034399
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0008139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008139
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0044822	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044822
GO_process	GO:0000059	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000059
GO_process	GO:0000060	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000060
GO_process	GO:0006607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006607
GO_process	GO:0006610	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006610
GO_process	GO:0016032	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016032
GO_process	GO:0043488	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043488
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0003723	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
GeneCards	TNPO1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TNPO1
GeneID	3842	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3842
GeneTree	ENSGT00550000074720	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074720
HGNC	HGNC:6401	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6401
HOGENOM	HOG000203940	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000203940&db=HOGENOM6
HOVERGEN	HBG058963	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG058963&db=HOVERGEN
HPA	CAB016325	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB016325
InParanoid	Q92973	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q92973
IntAct	Q92973	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q92973*
InterPro	IPR001494	http://www.ebi.ac.uk/interpro/entry/IPR001494
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
Jabion	3842	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3842
KEGG_Gene	hsa:3842	http://www.genome.jp/dbget-bin/www_bget?hsa:3842
MIM	602901	http://www.ncbi.nlm.nih.gov/omim/602901
MINT	MINT-94165	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-94165
OMA	THTIKSG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=THTIKSG
OrthoDB	EOG091G01O2	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01O2
PDB	1QBK	http://www.ebi.ac.uk/pdbe-srv/view/entry/1QBK
PDB	2H4M	http://www.ebi.ac.uk/pdbe-srv/view/entry/2H4M
PDB	2OT8	http://www.ebi.ac.uk/pdbe-srv/view/entry/2OT8
PDB	2QMR	http://www.ebi.ac.uk/pdbe-srv/view/entry/2QMR
PDB	2Z5J	http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z5J
PDB	2Z5K	http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z5K
PDB	2Z5M	http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z5M
PDB	2Z5N	http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z5N
PDB	2Z5O	http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z5O
PDB	4FDD	http://www.ebi.ac.uk/pdbe-srv/view/entry/4FDD
PDB	4FQ3	http://www.ebi.ac.uk/pdbe-srv/view/entry/4FQ3
PDB	4JLQ	http://www.ebi.ac.uk/pdbe-srv/view/entry/4JLQ
PDB	4OO6	http://www.ebi.ac.uk/pdbe-srv/view/entry/4OO6
PDB	5J3V	http://www.ebi.ac.uk/pdbe-srv/view/entry/5J3V
PDBsum	1QBK	http://www.ebi.ac.uk/pdbsum/1QBK
PDBsum	2H4M	http://www.ebi.ac.uk/pdbsum/2H4M
PDBsum	2OT8	http://www.ebi.ac.uk/pdbsum/2OT8
PDBsum	2QMR	http://www.ebi.ac.uk/pdbsum/2QMR
PDBsum	2Z5J	http://www.ebi.ac.uk/pdbsum/2Z5J
PDBsum	2Z5K	http://www.ebi.ac.uk/pdbsum/2Z5K
PDBsum	2Z5M	http://www.ebi.ac.uk/pdbsum/2Z5M
PDBsum	2Z5N	http://www.ebi.ac.uk/pdbsum/2Z5N
PDBsum	2Z5O	http://www.ebi.ac.uk/pdbsum/2Z5O
PDBsum	4FDD	http://www.ebi.ac.uk/pdbsum/4FDD
PDBsum	4FQ3	http://www.ebi.ac.uk/pdbsum/4FQ3
PDBsum	4JLQ	http://www.ebi.ac.uk/pdbsum/4JLQ
PDBsum	4OO6	http://www.ebi.ac.uk/pdbsum/4OO6
PDBsum	5J3V	http://www.ebi.ac.uk/pdbsum/5J3V
PROSITE	PS50166	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50166
PSORT	swissprot:TNPO1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TNPO1_HUMAN
PSORT-B	swissprot:TNPO1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TNPO1_HUMAN
PSORT2	swissprot:TNPO1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TNPO1_HUMAN
Pfam	PF03810	http://pfam.xfam.org/family/PF03810
PharmGKB	PA30192	http://www.pharmgkb.org/do/serve?objId=PA30192&objCls=Gene
Phobius	swissprot:TNPO1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TNPO1_HUMAN
PhylomeDB	Q92973	http://phylomedb.org/?seqid=Q92973
ProteinModelPortal	Q92973	http://www.proteinmodelportal.org/query/uniprot/Q92973
PubMed	10353245	http://www.ncbi.nlm.nih.gov/pubmed/10353245
PubMed	11682607	http://www.ncbi.nlm.nih.gov/pubmed/11682607
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16704975	http://www.ncbi.nlm.nih.gov/pubmed/16704975
PubMed	19124606	http://www.ncbi.nlm.nih.gov/pubmed/19124606
PubMed	19386897	http://www.ncbi.nlm.nih.gov/pubmed/19386897
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22223895	http://www.ncbi.nlm.nih.gov/pubmed/22223895
PubMed	8808633	http://www.ncbi.nlm.nih.gov/pubmed/8808633
PubMed	8986607	http://www.ncbi.nlm.nih.gov/pubmed/8986607
PubMed	9144189	http://www.ncbi.nlm.nih.gov/pubmed/9144189
PubMed	9524220	http://www.ncbi.nlm.nih.gov/pubmed/9524220
PubMed	9687515	http://www.ncbi.nlm.nih.gov/pubmed/9687515
Reactome	R-HSA-450513	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-450513
Reactome	R-HSA-5620924	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5620924
RefSeq	NP_002261	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002261
RefSeq	NP_694858	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_694858
RefSeq	XP_005248557	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005248557
SMART	SM00913	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00913
SMR	Q92973	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q92973
STRING	9606.ENSP00000336712	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000336712&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
TCDB	1.I.1.1	http://www.tcdb.org/search/result.php?tc=1.I.1.1
UCSC	uc003kci	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003kci&org=rat
UniGene	Hs.482497	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.482497
UniProtKB	TNPO1_HUMAN	http://www.uniprot.org/uniprot/TNPO1_HUMAN
UniProtKB-AC	Q92973	http://www.uniprot.org/uniprot/Q92973
charge	swissprot:TNPO1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TNPO1_HUMAN
eggNOG	ENOG410XPK2	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPK2
eggNOG	KOG2023	http://eggnogapi.embl.de/nog_data/html/tree/KOG2023
epestfind	swissprot:TNPO1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TNPO1_HUMAN
garnier	swissprot:TNPO1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TNPO1_HUMAN
helixturnhelix	swissprot:TNPO1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TNPO1_HUMAN
hmoment	swissprot:TNPO1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TNPO1_HUMAN
iep	swissprot:TNPO1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TNPO1_HUMAN
inforesidue	swissprot:TNPO1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TNPO1_HUMAN
neXtProt	NX_Q92973	http://www.nextprot.org/db/entry/NX_Q92973
octanol	swissprot:TNPO1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TNPO1_HUMAN
pepcoil	swissprot:TNPO1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TNPO1_HUMAN
pepdigest	swissprot:TNPO1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TNPO1_HUMAN
pepinfo	swissprot:TNPO1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TNPO1_HUMAN
pepnet	swissprot:TNPO1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TNPO1_HUMAN
pepstats	swissprot:TNPO1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TNPO1_HUMAN
pepwheel	swissprot:TNPO1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TNPO1_HUMAN
pepwindow	swissprot:TNPO1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TNPO1_HUMAN
sigcleave	swissprot:TNPO1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TNPO1_HUMAN
## Database	ID	URL or Descriptions
# AltName	CCG6_HUMAN	Neuronal voltage-gated calcium channel gamma-6 subunit
# Ensembl	ENST00000252729	ENSP00000252729; ENSG00000130433
# ExpressionAtlas	Q9BXT2	baseline and differential
# FUNCTION	CCG6_HUMAN	Thought to stabilize the calcium channel in an inactivated (closed) state. {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005891	voltage-gated calcium channel complex; NAS:UniProtKB.
# GO_function	GO:0005245	voltage-gated calcium channel activity; NAS:UniProtKB.
# GO_process	GO:0006816	calcium ion transport; NAS:UniProtKB.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q9BXT2	HS
# HGNC	HGNC:13625	CACNG6
# InterPro	IPR004031	PMP22/EMP/MP20/Claudin
# InterPro	IPR008368	VDCC_gsu
# InterPro	IPR008370	VDCC_g6su
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04010	MAPK signaling pathway
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05410	Hypertrophic cardiomyopathy (HCM)
# KEGG_Pathway	ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
# KEGG_Pathway	ko05414	Dilated cardiomyopathy
# MIM	606898	gene
# Organism	CCG6_HUMAN	Homo sapiens (Human)
# PRINTS	PR01792	VDCCGAMMA
# PRINTS	PR01794	VDCCGAMMA6
# Pfam	PF13903	Claudin_2
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# Reactome	R-HSA-5576893	Phase 2 - plateau phase
# Reactome	R-HSA-5576894	Phase 1 - inactivation of fast Na+ channels
# RecName	CCG6_HUMAN	Voltage-dependent calcium channel gamma-6 subunit
# RefSeq	NP_114103	NM_031897.2
# RefSeq	NP_665813	NM_145814.1
# RefSeq	NP_665814	NM_145815.1
# SIMILARITY	Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	CCG6_HUMAN	Membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUBUNIT	The L-type calcium channel is composed of five subunits	 alpha-1, alpha-2/delta, beta and gamma. 
# TCDB	8.A.16.1	the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family
# UCSC	uc002qct	human
# eggNOG	ENOG410IWHM	Eukaryota
# eggNOG	ENOG4111I1Z	LUCA
BLAST	swissprot:CCG6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CCG6_HUMAN
BioCyc	ZFISH:ENSG00000130433-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000130433-MONOMER
COXPRESdb	59285	http://coxpresdb.jp/data/gene/59285.shtml
CleanEx	HS_CACNG6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CACNG6
DOI	10.1006/geno.2000.6440	http://dx.doi.org/10.1006/geno.2000.6440
DOI	10.1016/S0378-1119(01)00738-7	http://dx.doi.org/10.1016/S0378-1119(01)00738-7
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF288386	http://www.ebi.ac.uk/ena/data/view/AF288386
EMBL	AF361352	http://www.ebi.ac.uk/ena/data/view/AF361352
EMBL	BC021552	http://www.ebi.ac.uk/ena/data/view/BC021552
Ensembl	ENST00000252729	http://www.ensembl.org/id/ENST00000252729
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005891
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	CACNG6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CACNG6
GeneID	59285	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=59285
GeneTree	ENSGT00390000007786	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000007786
HGNC	HGNC:13625	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13625
HOGENOM	HOG000293219	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000293219&db=HOGENOM6
HOVERGEN	HBG003868	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003868&db=HOVERGEN
InParanoid	Q9BXT2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9BXT2
InterPro	IPR004031	http://www.ebi.ac.uk/interpro/entry/IPR004031
InterPro	IPR008368	http://www.ebi.ac.uk/interpro/entry/IPR008368
InterPro	IPR008370	http://www.ebi.ac.uk/interpro/entry/IPR008370
Jabion	59285	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=59285
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:59285	http://www.genome.jp/dbget-bin/www_bget?hsa:59285
KEGG_Orthology	KO:K04871	http://www.genome.jp/dbget-bin/www_bget?KO:K04871
KEGG_Pathway	ko04010	http://www.genome.jp/kegg-bin/show_pathway?ko04010
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05410	http://www.genome.jp/kegg-bin/show_pathway?ko05410
KEGG_Pathway	ko05412	http://www.genome.jp/kegg-bin/show_pathway?ko05412
KEGG_Pathway	ko05414	http://www.genome.jp/kegg-bin/show_pathway?ko05414
MIM	606898	http://www.ncbi.nlm.nih.gov/omim/606898
OMA	GEANCTY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GEANCTY
OrthoDB	EOG091G0HUO	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0HUO
PRINTS	PR01792	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01792
PRINTS	PR01794	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01794
PSORT	swissprot:CCG6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CCG6_HUMAN
PSORT-B	swissprot:CCG6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CCG6_HUMAN
PSORT2	swissprot:CCG6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CCG6_HUMAN
Pfam	PF13903	http://pfam.xfam.org/family/PF13903
PharmGKB	PA26020	http://www.pharmgkb.org/do/serve?objId=PA26020&objCls=Gene
Phobius	swissprot:CCG6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CCG6_HUMAN
PhylomeDB	Q9BXT2	http://phylomedb.org/?seqid=Q9BXT2
ProteinModelPortal	Q9BXT2	http://www.proteinmodelportal.org/query/uniprot/Q9BXT2
PubMed	11170751	http://www.ncbi.nlm.nih.gov/pubmed/11170751
PubMed	11738816	http://www.ncbi.nlm.nih.gov/pubmed/11738816
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
Reactome	R-HSA-5576893	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576893
Reactome	R-HSA-5576894	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576894
RefSeq	NP_114103	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_114103
RefSeq	NP_665813	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_665813
RefSeq	NP_665814	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_665814
STRING	9606.ENSP00000252729	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000252729&targetmode=cogs
TCDB	8.A.16.1	http://www.tcdb.org/search/result.php?tc=8.A.16.1
UCSC	uc002qct	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002qct&org=rat
UniGene	Hs.631560	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.631560
UniProtKB	CCG6_HUMAN	http://www.uniprot.org/uniprot/CCG6_HUMAN
UniProtKB-AC	Q9BXT2	http://www.uniprot.org/uniprot/Q9BXT2
charge	swissprot:CCG6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CCG6_HUMAN
eggNOG	ENOG410IWHM	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IWHM
eggNOG	ENOG4111I1Z	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111I1Z
epestfind	swissprot:CCG6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CCG6_HUMAN
garnier	swissprot:CCG6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CCG6_HUMAN
helixturnhelix	swissprot:CCG6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CCG6_HUMAN
hmoment	swissprot:CCG6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CCG6_HUMAN
iep	swissprot:CCG6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CCG6_HUMAN
inforesidue	swissprot:CCG6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CCG6_HUMAN
neXtProt	NX_Q9BXT2	http://www.nextprot.org/db/entry/NX_Q9BXT2
octanol	swissprot:CCG6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CCG6_HUMAN
pepcoil	swissprot:CCG6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CCG6_HUMAN
pepdigest	swissprot:CCG6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CCG6_HUMAN
pepinfo	swissprot:CCG6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CCG6_HUMAN
pepnet	swissprot:CCG6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CCG6_HUMAN
pepstats	swissprot:CCG6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CCG6_HUMAN
pepwheel	swissprot:CCG6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CCG6_HUMAN
pepwindow	swissprot:CCG6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CCG6_HUMAN
sigcleave	swissprot:CCG6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CCG6_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TMCO1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UM00-1; Sequence=Displayed; Name=2; IsoId=Q9UM00-2; Sequence=VSP_019505; Note=No experimental confirmation available.; 
# AltName	Transmembrane and coiled-coil domain-containing protein 1 {ECO	0000305}
# AltName	Transmembrane and coiled-coil domains protein 4 {ECO	0000305}
# AltName	Xenogeneic cross-immune protein PCIA3 {ECO	0000303|Ref.2}
# BioGrid	119995	42
# ChiTaRS	TMCO1	human
# DISEASE	TMCO1_HUMAN	Craniofacial dysmorphism, skeletal anomalies and mental retardation syndrome (CFSMR) [MIM 213980]  A disorder characterized by craniofacial and skeletal anomalies, associated with mental retardation. Typical craniofacial dysmorphism include brachycephaly, highly arched bushy eyebrows, synophrys, long eyelashes, low-set ears, microdontism of primary teeth, and generalized gingival hyperplasia, whereas Sprengel deformity of scapula, fusion of spine, rib abnormities, pectus excavatum, and pes planus represent skeletal anomalies. {ECO 0000269|PubMed 20018682, ECO 0000269|PubMed 23320496, ECO 0000269|PubMed 24194475}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	TMCO1_HUMAN	Glaucoma, primary open angle (POAG) [MIM 137760]  A complex and genetically heterogeneous ocular disorder characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. In some cases, POAG shows digenic inheritance involving mutations in CYP1B1 and MYOC genes. {ECO 0000269|PubMed 21532571, ECO 0000269|PubMed 22714896}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# Ensembl	ENST00000392129	ENSP00000375975; ENSG00000143183. [Q9UM00-1]
# ExpressionAtlas	Q9UM00	baseline and differential
# FUNCTION	TMCO1_HUMAN	Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis (PubMed 27212239). In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store (PubMed 27212239). {ECO 0000269|PubMed 27212239}. 
# GO_component	GO:0000139	Golgi membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005783	endoplasmic reticulum; IDA:HPA.
# GO_component	GO:0030176	integral component of endoplasmic reticulum membrane; IDA:UniProtKB.
# GO_function	GO:0005262	calcium channel activity; IDA:UniProtKB.
# GO_process	GO:0006983	ER overload response; IDA:UniProtKB.
# GO_process	GO:0032469	endoplasmic reticulum calcium ion homeostasis; IDA:UniProtKB.
# GO_process	GO:0070588	calcium ion transmembrane transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9UM00	HS
# HGNC	HGNC:18188	TMCO1
# IntAct	Q9UM00	20
# InterPro	IPR002809	EMC3/TMCO1
# InterPro	IPR008559	TMCO1
# MIM	137760	phenotype
# MIM	213980	phenotype
# MIM	614123	gene
# Organism	TMCO1_HUMAN	Homo sapiens (Human)
# Orphanet	1394	Cerebro-facio-thoracic dysplasia
# PANTHER	PTHR20917	PTHR20917
# PIRSF	PIRSF023322	DUF841_euk
# Pfam	PF01956	DUF106
# Proteomes	UP000005640	Chromosome 1
# RecName	Calcium load-activated calcium channel {ECO:0000305|PubMed	27212239}
# RefSeq	NP_061899	NM_019026.4
# SEQUENCE CAUTION	Sequence=AAC25388.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAK07514.1; Type=Frameshift; Positions=Several; Evidence={ECO	0000305}; Sequence=AAK07549.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};
# SIMILARITY	Belongs to the TMCO1 family. {ECO	0000305}. 
# SMART	SM01415	DUF106
# SUBCELLULAR LOCATION	TMCO1_HUMAN	Endoplasmic reticulum membrane {ECO 0000269|PubMed 10393320, ECO 0000269|PubMed 27212239}; Multi- pass membrane protein {ECO 0000269|PubMed 10393320, ECO 0000269|PubMed 27212239}. Golgi apparatus membrane {ECO 0000269|PubMed 10393320}; Multi-pass membrane protein {ECO 0000269|PubMed 10393320}. Note=The first transmembrane region is required for localization to the endoplasmic reticulum (PubMed 27212239). A publication reported localization in cytoplasm and nucleus (PubMed 22714896). Nuclear localization is however in contradiction with two other reports (PubMed 10393320, PubMed 27212239). {ECO 0000269|PubMed 10393320, ECO 0000269|PubMed 22714896, ECO 0000269|PubMed 27212239}. 
# SUBUNIT	TMCO1_HUMAN	Homodimer and homotetramer (PubMed 27212239). Homodimer under resting conditions; forms homotetramers following and endoplasmic reticulum calcium overload (PubMed 27212239). {ECO 0000269|PubMed 27212239}. 
# TCDB	1.A.106.1	the calcium load-activated calcium channel (clac) family
# TISSUE SPECIFICITY	TMCO1_HUMAN	Widely expressed in adult and fetal tissues, with higher levels in thymus, prostate, testis and small intestine and lower levels in brain, placenta, lung and kidney (PubMed 10393320, PubMed 20018682). Present in most tissues in the eye, including the trabecular meshwork and retina (at protein level) (PubMed 22714896). {ECO 0000269|PubMed 10393320, ECO 0000269|PubMed 20018682, ECO 0000269|PubMed 22714896}. 
# TopDownProteomics	Q9UM00-1	-. [Q9UM00-1]
# UCSC	uc057mzb	human. [Q9UM00-1]
# eggNOG	ENOG410XR8B	LUCA
# eggNOG	KOG3312	Eukaryota
BLAST	swissprot:TMCO1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TMCO1_HUMAN
COXPRESdb	54499	http://coxpresdb.jp/data/gene/54499.shtml
CleanEx	HS_TMCO1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TMCO1
DOI	10.1002/ajmg.a.36248	http://dx.doi.org/10.1002/ajmg.a.36248
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.cell.2016.04.051	http://dx.doi.org/10.1016/j.cell.2016.04.051
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng.824	http://dx.doi.org/10.1038/ng.824
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.0908457107	http://dx.doi.org/10.1073/pnas.0908457107
DOI	10.1093/oxfordjournals.jbchem.a022435	http://dx.doi.org/10.1093/oxfordjournals.jbchem.a022435
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/cge.12088	http://dx.doi.org/10.1111/cge.12088
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1167/iovs.11-9047	http://dx.doi.org/10.1167/iovs.11-9047
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AB020980	http://www.ebi.ac.uk/ena/data/view/AB020980
EMBL	AF070626	http://www.ebi.ac.uk/ena/data/view/AF070626
EMBL	AF274935	http://www.ebi.ac.uk/ena/data/view/AF274935
EMBL	AF277194	http://www.ebi.ac.uk/ena/data/view/AF277194
EMBL	AK316610	http://www.ebi.ac.uk/ena/data/view/AK316610
EMBL	AL451074	http://www.ebi.ac.uk/ena/data/view/AL451074
EMBL	AY359027	http://www.ebi.ac.uk/ena/data/view/AY359027
EMBL	AY763589	http://www.ebi.ac.uk/ena/data/view/AY763589
EMBL	BC000104	http://www.ebi.ac.uk/ena/data/view/BC000104
Ensembl	ENST00000392129	http://www.ensembl.org/id/ENST00000392129
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0030176	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030176
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_process	GO:0006983	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006983
GO_process	GO:0032469	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032469
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	TMCO1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TMCO1
GeneID	54499	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54499
GeneTree	ENSGT00390000002659	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002659
HGNC	HGNC:18188	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18188
HOGENOM	HOG000240371	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000240371&db=HOGENOM6
HOVERGEN	HBG054437	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054437&db=HOVERGEN
HPA	HPA054768	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA054768
InParanoid	Q9UM00	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UM00
IntAct	Q9UM00	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9UM00*
InterPro	IPR002809	http://www.ebi.ac.uk/interpro/entry/IPR002809
InterPro	IPR008559	http://www.ebi.ac.uk/interpro/entry/IPR008559
Jabion	54499	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=54499
KEGG_Gene	hsa:54499	http://www.genome.jp/dbget-bin/www_bget?hsa:54499
MIM	137760	http://www.ncbi.nlm.nih.gov/omim/137760
MIM	213980	http://www.ncbi.nlm.nih.gov/omim/213980
MIM	614123	http://www.ncbi.nlm.nih.gov/omim/614123
Orphanet	1394	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1394
PANTHER	PTHR20917	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20917
PSORT	swissprot:TMCO1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TMCO1_HUMAN
PSORT-B	swissprot:TMCO1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TMCO1_HUMAN
PSORT2	swissprot:TMCO1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TMCO1_HUMAN
Pfam	PF01956	http://pfam.xfam.org/family/PF01956
PharmGKB	PA142670792	http://www.pharmgkb.org/do/serve?objId=PA142670792&objCls=Gene
Phobius	swissprot:TMCO1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TMCO1_HUMAN
PhylomeDB	Q9UM00	http://phylomedb.org/?seqid=Q9UM00
ProteinModelPortal	Q9UM00	http://www.proteinmodelportal.org/query/uniprot/Q9UM00
PubMed	10393320	http://www.ncbi.nlm.nih.gov/pubmed/10393320
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	20018682	http://www.ncbi.nlm.nih.gov/pubmed/20018682
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21532571	http://www.ncbi.nlm.nih.gov/pubmed/21532571
PubMed	22714896	http://www.ncbi.nlm.nih.gov/pubmed/22714896
PubMed	23320496	http://www.ncbi.nlm.nih.gov/pubmed/23320496
PubMed	24194475	http://www.ncbi.nlm.nih.gov/pubmed/24194475
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	27212239	http://www.ncbi.nlm.nih.gov/pubmed/27212239
RefSeq	NP_061899	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061899
SMART	SM01415	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01415
STRING	9606.ENSP00000375975	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000375975&targetmode=cogs
TCDB	1.A.106.1	http://www.tcdb.org/search/result.php?tc=1.A.106.1
UCSC	uc057mzb	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc057mzb&org=rat
UniGene	Hs.31498	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.31498
UniProtKB	TMCO1_HUMAN	http://www.uniprot.org/uniprot/TMCO1_HUMAN
UniProtKB-AC	Q9UM00	http://www.uniprot.org/uniprot/Q9UM00
charge	swissprot:TMCO1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TMCO1_HUMAN
eggNOG	ENOG410XR8B	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XR8B
eggNOG	KOG3312	http://eggnogapi.embl.de/nog_data/html/tree/KOG3312
epestfind	swissprot:TMCO1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TMCO1_HUMAN
garnier	swissprot:TMCO1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TMCO1_HUMAN
helixturnhelix	swissprot:TMCO1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TMCO1_HUMAN
hmoment	swissprot:TMCO1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TMCO1_HUMAN
iep	swissprot:TMCO1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TMCO1_HUMAN
inforesidue	swissprot:TMCO1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TMCO1_HUMAN
neXtProt	NX_Q9UM00	http://www.nextprot.org/db/entry/NX_Q9UM00
octanol	swissprot:TMCO1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TMCO1_HUMAN
pepcoil	swissprot:TMCO1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TMCO1_HUMAN
pepdigest	swissprot:TMCO1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TMCO1_HUMAN
pepinfo	swissprot:TMCO1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TMCO1_HUMAN
pepnet	swissprot:TMCO1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TMCO1_HUMAN
pepstats	swissprot:TMCO1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TMCO1_HUMAN
pepwheel	swissprot:TMCO1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TMCO1_HUMAN
pepwindow	swissprot:TMCO1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TMCO1_HUMAN
sigcleave	swissprot:TMCO1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TMCO1_HUMAN
## Database	ID	URL or Descriptions
# AltName	COX7S_HUMAN	Cytochrome c oxidase subunit VIIa 3
# CAUTION	Could be the product of a pseudogene. {ECO	0000305}.
# CDD	cd00928	Cyt_c_Oxidase_VIIa
# GO_component	GO:0005746	mitochondrial respiratory chain; IEA:InterPro.
# GO_function	GO:0004129	cytochrome-c oxidase activity; IEA:InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# Gene3D	4.10.91.10	-; 1.
# HGNC	HGNC:2290	COX7A2P2
# InterPro	IPR003177	Cyt_c_oxidase_su7a
# MIM	123997	gene
# Organism	COX7S_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10510	PTHR10510
# Proteomes	UP000005640	Unplaced
# RecName	COX7S_HUMAN	Putative cytochrome c oxidase subunit 7A3, mitochondrial
# SIMILARITY	Belongs to the cytochrome c oxidase VIIa family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	COX7S_HUMAN	Mitochondrion inner membrane {ECO 0000250}. 
# SUPFAM	SSF81419	SSF81419
BLAST	swissprot:COX7S_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:COX7S_HUMAN
BioCyc	ZFISH:HS03213-MONOMER	http://biocyc.org/getid?id=ZFISH:HS03213-MONOMER
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
EMBL	AC004544	http://www.ebi.ac.uk/ena/data/view/AC004544
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005746	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005746
GO_function	GO:0004129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004129
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
Gene3D	4.10.91.10	http://www.cathdb.info/version/latest/superfamily/4.10.91.10
GeneCards	COX7A2P2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=COX7A2P2
HGNC	HGNC:2290	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2290
HOVERGEN	HBG051095	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051095&db=HOVERGEN
InParanoid	O60397	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O60397
InterPro	IPR003177	http://www.ebi.ac.uk/interpro/entry/IPR003177
MIM	123997	http://www.ncbi.nlm.nih.gov/omim/123997
PANTHER	PTHR10510	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10510
PSORT	swissprot:COX7S_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:COX7S_HUMAN
PSORT-B	swissprot:COX7S_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:COX7S_HUMAN
PSORT2	swissprot:COX7S_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:COX7S_HUMAN
Phobius	swissprot:COX7S_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:COX7S_HUMAN
PhylomeDB	O60397	http://phylomedb.org/?seqid=O60397
ProteinModelPortal	O60397	http://www.proteinmodelportal.org/query/uniprot/O60397
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
SMR	O60397	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O60397
SUPFAM	SSF81419	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81419
UniProtKB	COX7S_HUMAN	http://www.uniprot.org/uniprot/COX7S_HUMAN
UniProtKB-AC	O60397	http://www.uniprot.org/uniprot/O60397
charge	swissprot:COX7S_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:COX7S_HUMAN
epestfind	swissprot:COX7S_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:COX7S_HUMAN
garnier	swissprot:COX7S_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:COX7S_HUMAN
helixturnhelix	swissprot:COX7S_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:COX7S_HUMAN
hmoment	swissprot:COX7S_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:COX7S_HUMAN
iep	swissprot:COX7S_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:COX7S_HUMAN
inforesidue	swissprot:COX7S_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:COX7S_HUMAN
neXtProt	NX_O60397	http://www.nextprot.org/db/entry/NX_O60397
octanol	swissprot:COX7S_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:COX7S_HUMAN
pepcoil	swissprot:COX7S_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:COX7S_HUMAN
pepdigest	swissprot:COX7S_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:COX7S_HUMAN
pepinfo	swissprot:COX7S_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:COX7S_HUMAN
pepnet	swissprot:COX7S_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:COX7S_HUMAN
pepstats	swissprot:COX7S_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:COX7S_HUMAN
pepwheel	swissprot:COX7S_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:COX7S_HUMAN
pepwindow	swissprot:COX7S_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:COX7S_HUMAN
sigcleave	swissprot:COX7S_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:COX7S_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCMB3_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=3d; IsoId=Q9NPA1-1; Sequence=Displayed; Name=2; Synonyms=3a; IsoId=Q9NPA1-2; Sequence=VSP_009827; Name=3; Synonyms=3c; IsoId=Q9NPA1-3; Sequence=VSP_009828; Name=4; Synonyms=3b; IsoId=Q9NPA1-4; Sequence=VSP_009829, VSP_009830; Name=5; IsoId=Q9NPA1-5; Sequence=VSP_009827, VSP_046090, VSP_046091; Note=No experimental confirmation available.; 
# AltName	KCMB3_HUMAN	BK channel subunit beta-3
# AltName	KCMB3_HUMAN	Calcium-activated potassium channel, subfamily M subunit beta-3
# AltName	KCMB3_HUMAN	Charybdotoxin receptor subunit beta-3
# AltName	KCMB3_HUMAN	K(VCA)beta-3
# AltName	KCMB3_HUMAN	Maxi K channel subunit beta-3
# AltName	KCMB3_HUMAN	Slo-beta-3
# CCDS	CCDS3225	-. [Q9NPA1-2]
# CCDS	CCDS3226	-. [Q9NPA1-1]
# CCDS	CCDS43172	-. [Q9NPA1-4]
# CCDS	CCDS43173	-. [Q9NPA1-3]
# CCDS	CCDS54683	-. [Q9NPA1-5]
# DOMAIN	KCMB3_HUMAN	Isoform 4 cytoplasmic N-terminal domain participates in the partial inactivation of KCNMA1, possibly by binding to a receptor site. 
# DOMAIN	KCMB3_HUMAN	The extracellular domain forms gates to block ion permeation, providing a mechanism by which current can be rapidly diminished upon cellular repolarization. 
# DrugBank	DB00721	Procaine
# DrugBank	DB01110	Miconazole
# Ensembl	ENST00000314235	ENSP00000319370; ENSG00000171121. [Q9NPA1-1]
# Ensembl	ENST00000349697	ENSP00000327866; ENSG00000171121. [Q9NPA1-2]
# Ensembl	ENST00000392685	ENSP00000376451; ENSG00000171121. [Q9NPA1-3]
# Ensembl	ENST00000392686	ENSP00000376452; ENSG00000171121. [Q9NPA1-4]
# Ensembl	ENST00000485523	ENSP00000418536; ENSG00000171121. [Q9NPA1-4]
# Ensembl	ENST00000497599	ENSP00000417091; ENSG00000171121. [Q9NPA1-5]
# ExpressionAtlas	Q9NPA1	baseline and differential
# FUNCTION	KCMB3_HUMAN	Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer. {ECO 0000269|PubMed 10766764, ECO 0000269|PubMed 10864947}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IDA:UniProtKB.
# GO_function	GO:0015269	calcium-activated potassium channel activity; IDA:UniProtKB.
# GO_function	GO:0015459	potassium channel regulator activity; NAS:UniProtKB.
# GO_process	GO:0001508	action potential; IDA:UniProtKB.
# GO_process	GO:0005513	detection of calcium ion; IDA:UniProtKB.
# GO_process	GO:0006813	potassium ion transport; IDA:UniProtKB.
# GO_process	GO:0007268	chemical synaptic transmission; IBA:GO_Central.
# GO_process	GO:0019228	neuronal action potential; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q9NPA1	HS
# HGNC	HGNC:6287	KCNMB3
# InterPro	IPR003930	K_chnl_Ca-activ_BK_bsu
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04270	Vascular smooth muscle contraction
# MIM	605222	gene
# Organism	KCMB3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10258	PTHR10258
# PTM	KCMB3_HUMAN	N-glycosylated. {ECO 0000269|PubMed 10792058}. 
# PTM	KCMB3_HUMAN	The extracellular domain contains disulfide bond essential for the gating mechanism. 
# Pfam	PF03185	CaKB
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-1296052	Ca2+ activated K+ channels
# Reactome	R-HSA-418457	cGMP effects
# RecName	KCMB3_HUMAN	Calcium-activated potassium channel subunit beta-3
# RefSeq	NP_001157149	NM_001163677.1. [Q9NPA1-5]
# RefSeq	NP_055222	NM_014407.3. [Q9NPA1-1]
# RefSeq	NP_741979	NM_171828.2. [Q9NPA1-2]
# RefSeq	NP_741980	NM_171829.2. [Q9NPA1-4]
# RefSeq	NP_741981	NM_171830.1. [Q9NPA1-3]
# SIMILARITY	Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB3 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCMB3_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB3 per KCNMA1 tetramer. {ECO:0000269|PubMed	10692449}. 
# TCDB	8.A.14.1	the ca(2+)-activated k(+) channel auxiliary subunit slowpoke-Beta (sloBeta) family
# TISSUE SPECIFICITY	KCMB3_HUMAN	Isoform 1, isoform 3 and isoform 4 are widely expressed. Isoform 2 is expressed placenta, pancreas, kidney and heart. Isoform 1 and isoform 3 are highly expressed in pancreas and testis. {ECO 0000269|PubMed 10585773, ECO 0000269|PubMed 10692449, ECO 0000269|PubMed 10766764}. 
# UCSC	uc003fjm	human. [Q9NPA1-1]
# eggNOG	ENOG410IF7H	Eukaryota
# eggNOG	ENOG410YQCT	LUCA
BLAST	swissprot:KCMB3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCMB3_HUMAN
COXPRESdb	27094	http://coxpresdb.jp/data/gene/27094.shtml
CleanEx	HS_KCNMB2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNMB2
CleanEx	HS_KCNMB3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNMB3
DOI	10.1006/geno.1999.5975	http://dx.doi.org/10.1006/geno.1999.5975
DOI	10.1016/S0014-5793(00)01584-2	http://dx.doi.org/10.1016/S0014-5793(00)01584-2
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/nsb932	http://dx.doi.org/10.1038/nsb932
DOI	10.1073/pnas.100118597	http://dx.doi.org/10.1073/pnas.100118597
DOI	10.1074/jbc.275.9.6453	http://dx.doi.org/10.1074/jbc.275.9.6453
DOI	10.1074/jbc.M910187199	http://dx.doi.org/10.1074/jbc.M910187199
DOI	10.1085/jgp.117.6.583	http://dx.doi.org/10.1085/jgp.117.6.583
DOI	10.1085/jgp.117.6.607	http://dx.doi.org/10.1085/jgp.117.6.607
DOI	10.1152/nips.01387.2002	http://dx.doi.org/10.1152/nips.01387.2002
DOI	10.1152/physiolgenomics.00110.2003	http://dx.doi.org/10.1152/physiolgenomics.00110.2003
DrugBank	DB00721	http://www.drugbank.ca/drugs/DB00721
DrugBank	DB01110	http://www.drugbank.ca/drugs/DB01110
EMBL	AC007823	http://www.ebi.ac.uk/ena/data/view/AC007823
EMBL	AC076966	http://www.ebi.ac.uk/ena/data/view/AC076966
EMBL	AF139471	http://www.ebi.ac.uk/ena/data/view/AF139471
EMBL	AF160968	http://www.ebi.ac.uk/ena/data/view/AF160968
EMBL	AF170916	http://www.ebi.ac.uk/ena/data/view/AF170916
EMBL	AF204159	http://www.ebi.ac.uk/ena/data/view/AF204159
EMBL	AF204160	http://www.ebi.ac.uk/ena/data/view/AF204160
EMBL	AF204161	http://www.ebi.ac.uk/ena/data/view/AF204161
EMBL	AF204162	http://www.ebi.ac.uk/ena/data/view/AF204162
EMBL	AF214561	http://www.ebi.ac.uk/ena/data/view/AF214561
EMBL	AK304837	http://www.ebi.ac.uk/ena/data/view/AK304837
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
Ensembl	ENST00000314235	http://www.ensembl.org/id/ENST00000314235
Ensembl	ENST00000349697	http://www.ensembl.org/id/ENST00000349697
Ensembl	ENST00000392685	http://www.ensembl.org/id/ENST00000392685
Ensembl	ENST00000392686	http://www.ensembl.org/id/ENST00000392686
Ensembl	ENST00000485523	http://www.ensembl.org/id/ENST00000485523
Ensembl	ENST00000497599	http://www.ensembl.org/id/ENST00000497599
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_function	GO:0015269	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015269
GO_function	GO:0015459	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015459
GO_process	GO:0001508	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001508
GO_process	GO:0005513	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005513
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0019228	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019228
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	KCNMB3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNMB3
GeneID	27094	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27094
GeneTree	ENSGT00390000015997	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000015997
HGNC	HGNC:6287	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6287
HOGENOM	HOG000290180	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000290180&db=HOGENOM6
HOVERGEN	HBG108059	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108059&db=HOVERGEN
HPA	HPA015665	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA015665
HPA	HPA019185	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA019185
InParanoid	Q9NPA1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NPA1
InterPro	IPR003930	http://www.ebi.ac.uk/interpro/entry/IPR003930
Jabion	27094	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=27094
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:27094	http://www.genome.jp/dbget-bin/www_bget?hsa:27094
KEGG_Orthology	KO:K04939	http://www.genome.jp/dbget-bin/www_bget?KO:K04939
KEGG_Pathway	ko04270	http://www.genome.jp/kegg-bin/show_pathway?ko04270
MIM	605222	http://www.ncbi.nlm.nih.gov/omim/605222
OMA	KPFMLST	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KPFMLST
OrthoDB	EOG091G0MVO	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0MVO
PANTHER	PTHR10258	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10258
PSORT	swissprot:KCMB3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCMB3_HUMAN
PSORT-B	swissprot:KCMB3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCMB3_HUMAN
PSORT2	swissprot:KCMB3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCMB3_HUMAN
Pfam	PF03185	http://pfam.xfam.org/family/PF03185
PharmGKB	PA30067	http://www.pharmgkb.org/do/serve?objId=PA30067&objCls=Gene
Phobius	swissprot:KCMB3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCMB3_HUMAN
PhylomeDB	Q9NPA1	http://phylomedb.org/?seqid=Q9NPA1
ProteinModelPortal	Q9NPA1	http://www.proteinmodelportal.org/query/uniprot/Q9NPA1
PubMed	10585773	http://www.ncbi.nlm.nih.gov/pubmed/10585773
PubMed	10692449	http://www.ncbi.nlm.nih.gov/pubmed/10692449
PubMed	10766764	http://www.ncbi.nlm.nih.gov/pubmed/10766764
PubMed	10792058	http://www.ncbi.nlm.nih.gov/pubmed/10792058
PubMed	10828459	http://www.ncbi.nlm.nih.gov/pubmed/10828459
PubMed	10864947	http://www.ncbi.nlm.nih.gov/pubmed/10864947
PubMed	11382808	http://www.ncbi.nlm.nih.gov/pubmed/11382808
PubMed	11382809	http://www.ncbi.nlm.nih.gov/pubmed/11382809
PubMed	12136044	http://www.ncbi.nlm.nih.gov/pubmed/12136044
PubMed	12740608	http://www.ncbi.nlm.nih.gov/pubmed/12740608
PubMed	14612589	http://www.ncbi.nlm.nih.gov/pubmed/14612589
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
Reactome	R-HSA-1296052	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296052
Reactome	R-HSA-418457	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418457
RefSeq	NP_001157149	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001157149
RefSeq	NP_055222	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055222
RefSeq	NP_741979	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_741979
RefSeq	NP_741980	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_741980
RefSeq	NP_741981	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_741981
SMR	Q9NPA1	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9NPA1
STRING	9606.ENSP00000319370	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000319370&targetmode=cogs
TCDB	8.A.14.1	http://www.tcdb.org/search/result.php?tc=8.A.14.1
UCSC	uc003fjm	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003fjm&org=rat
UniGene	Hs.591285	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.591285
UniProtKB	KCMB3_HUMAN	http://www.uniprot.org/uniprot/KCMB3_HUMAN
UniProtKB-AC	Q9NPA1	http://www.uniprot.org/uniprot/Q9NPA1
charge	swissprot:KCMB3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCMB3_HUMAN
eggNOG	ENOG410IF7H	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IF7H
eggNOG	ENOG410YQCT	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YQCT
epestfind	swissprot:KCMB3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCMB3_HUMAN
garnier	swissprot:KCMB3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCMB3_HUMAN
helixturnhelix	swissprot:KCMB3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCMB3_HUMAN
hmoment	swissprot:KCMB3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCMB3_HUMAN
iep	swissprot:KCMB3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCMB3_HUMAN
inforesidue	swissprot:KCMB3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCMB3_HUMAN
neXtProt	NX_Q9NPA1	http://www.nextprot.org/db/entry/NX_Q9NPA1
octanol	swissprot:KCMB3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCMB3_HUMAN
pepcoil	swissprot:KCMB3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCMB3_HUMAN
pepdigest	swissprot:KCMB3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCMB3_HUMAN
pepinfo	swissprot:KCMB3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCMB3_HUMAN
pepnet	swissprot:KCMB3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCMB3_HUMAN
pepstats	swissprot:KCMB3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCMB3_HUMAN
pepwheel	swissprot:KCMB3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCMB3_HUMAN
pepwindow	swissprot:KCMB3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCMB3_HUMAN
sigcleave	swissprot:KCMB3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCMB3_HUMAN
## Database	ID	URL or Descriptions
# AltName	ACHA9_HUMAN	Nicotinic acetylcholine receptor subunit alpha-9
# BioGrid	120731	73
# ChiTaRS	CHRNA9	human
# DrugBank	DB00184	Nicotine
# DrugBank	DB00674	Galantamine
# DrugBank	DB00898	Ethanol
# Ensembl	ENST00000310169	ENSP00000312663; ENSG00000174343
# FUNCTION	ACHA9_HUMAN	Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane (PubMed 11752216, PubMed 25282151). The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed 11752216, PubMed 25282151). In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion (PubMed 11021840). {ECO 0000269|PubMed 11021840, ECO 0000269|PubMed 11752216, ECO 0000269|PubMed 25282151, ECO 0000305}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005892	acetylcholine-gated channel complex; IDA:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0004889	acetylcholine-activated cation-selective channel activity; IEA:Ensembl.
# GO_function	GO:0005262	calcium channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0015276	ligand-gated ion channel activity; TAS:Reactome.
# GO_function	GO:0022848	acetylcholine-gated cation channel activity; IDA:UniProtKB.
# GO_function	GO:0042166	acetylcholine binding; IBA:GO_Central.
# GO_process	GO:0007204	positive regulation of cytosolic calcium ion concentration; IGI:MGI.
# GO_process	GO:0007271	synaptic transmission, cholinergic; IBA:GO_Central.
# GO_process	GO:0042472	inner ear morphogenesis; IEA:Ensembl.
# GO_process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0050877	neurological system process
# Gene3D	1.20.120.370	-; 2.
# Gene3D	2.70.170.10	-; 1.
# Genevisible	Q9UGM1	HS
# HGNC	HGNC:14079	CHRNA9
# InterPro	IPR002394	Nicotinic_acetylcholine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# InterPro	IPR027361	Acetylcholine_rcpt_TM
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# MIM	605116	gene
# MISCELLANEOUS	The hetero-oligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic acetylcholine receptor antagonist). {ECO:0000305|PubMed	11752216}. 
# Organism	ACHA9_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR18945	PTHR18945; 2
# PDB	4D01	X-ray; 1.80 A; A=26-237
# PDB	4UXU	X-ray; 1.71 A; A/B=26-237
# PDB	4UY2	X-ray; 2.70 A; A/B=26-237
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00254	NICOTINICR
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# PTM	ACHA9_HUMAN	N-glycosylated. {ECO 0000269|PubMed 25282151}. 
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-629594	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
# RecName	ACHA9_HUMAN	Neuronal acetylcholine receptor subunit alpha-9
# RefSeq	NP_060051	NM_017581.3
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 9/CHRNA9 sub-subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	ACHA9_HUMAN	Cell junction, synapse, postsynaptic cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. Cell membrane {ECO 0000269|PubMed 25282151}; Multi-pass membrane protein {ECO 0000305|PubMed 25282151}. 
# SUBUNIT	Can form homo- or hetero-oligomeric channels in conjunction with CHRNA10 (PubMed:11752216). The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 hetero-oligomers. {ECO	0000269|PubMed:11752216}. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TIGRFAMs	TIGR00860	LIC
# TISSUE SPECIFICITY	ACHA9_HUMAN	Expressed in cochlea, keratinocytes, pituitary gland, B-cells and T-cells. {ECO 0000269|PubMed 11021840, ECO 0000269|PubMed 11752216, ECO 0000269|PubMed 15531379}. 
# UCSC	uc003gva	human
# eggNOG	ENOG410XQGR	LUCA
# eggNOG	KOG3645	Eukaryota
BLAST	swissprot:ACHA9_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ACHA9_HUMAN
BioCyc	ZFISH:ENSG00000174343-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000174343-MONOMER
COXPRESdb	55584	http://coxpresdb.jp/data/gene/55584.shtml
CleanEx	HS_CHRNA9	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CHRNA9
DIP	DIP-61053N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-61053N
DOI	10.1016/S0002-9440(10)64651-2	http://dx.doi.org/10.1016/S0002-9440(10)64651-2
DOI	10.1016/j.lfs.2004.05.031	http://dx.doi.org/10.1016/j.lfs.2004.05.031
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/nsmb.2900	http://dx.doi.org/10.1038/nsmb.2900
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1124/mol.61.1.150	http://dx.doi.org/10.1124/mol.61.1.150
DOI	10.1159/000069804	http://dx.doi.org/10.1159/000069804
DrugBank	DB00184	http://www.drugbank.ca/drugs/DB00184
DrugBank	DB00674	http://www.drugbank.ca/drugs/DB00674
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
EMBL	AC118275	http://www.ebi.ac.uk/ena/data/view/AC118275
EMBL	AF227732	http://www.ebi.ac.uk/ena/data/view/AF227732
EMBL	AJ243342	http://www.ebi.ac.uk/ena/data/view/AJ243342
EMBL	AY123244	http://www.ebi.ac.uk/ena/data/view/AY123244
EMBL	BC113549	http://www.ebi.ac.uk/ena/data/view/BC113549
EMBL	BC113575	http://www.ebi.ac.uk/ena/data/view/BC113575
Ensembl	ENST00000310169	http://www.ensembl.org/id/ENST00000310169
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005892	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005892
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0004889	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004889
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_function	GO:0022848	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022848
GO_function	GO:0042166	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042166
GO_process	GO:0007204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007204
GO_process	GO:0007271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007271
GO_process	GO:0042472	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042472
GO_process	GO:0050910	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050910
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
Gene3D	1.20.120.370	http://www.cathdb.info/version/latest/superfamily/1.20.120.370
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	CHRNA9	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CHRNA9
GeneID	55584	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55584
GeneTree	ENSGT00790000122957	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00790000122957
H-InvDB	HIX0031380	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0031380
HGNC	HGNC:14079	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14079
HOGENOM	HOG000006756	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006756&db=HOGENOM6
HOVERGEN	HBG003756	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003756&db=HOVERGEN
InParanoid	Q9UGM1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UGM1
InterPro	IPR002394	http://www.ebi.ac.uk/interpro/entry/IPR002394
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
InterPro	IPR027361	http://www.ebi.ac.uk/interpro/entry/IPR027361
Jabion	55584	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55584
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:55584	http://www.genome.jp/dbget-bin/www_bget?hsa:55584
KEGG_Orthology	KO:K04810	http://www.genome.jp/dbget-bin/www_bget?KO:K04810
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
MIM	605116	http://www.ncbi.nlm.nih.gov/omim/605116
OMA	MGMDSGD	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MGMDSGD
OrthoDB	EOG091G0R20	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0R20
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PDB	4D01	http://www.ebi.ac.uk/pdbe-srv/view/entry/4D01
PDB	4UXU	http://www.ebi.ac.uk/pdbe-srv/view/entry/4UXU
PDB	4UY2	http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY2
PDBsum	4D01	http://www.ebi.ac.uk/pdbsum/4D01
PDBsum	4UXU	http://www.ebi.ac.uk/pdbsum/4UXU
PDBsum	4UY2	http://www.ebi.ac.uk/pdbsum/4UY2
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00254	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00254
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:ACHA9_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ACHA9_HUMAN
PSORT-B	swissprot:ACHA9_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ACHA9_HUMAN
PSORT2	swissprot:ACHA9_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ACHA9_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA26493	http://www.pharmgkb.org/do/serve?objId=PA26493&objCls=Gene
Phobius	swissprot:ACHA9_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ACHA9_HUMAN
PhylomeDB	Q9UGM1	http://phylomedb.org/?seqid=Q9UGM1
ProteinModelPortal	Q9UGM1	http://www.proteinmodelportal.org/query/uniprot/Q9UGM1
PubMed	11021840	http://www.ncbi.nlm.nih.gov/pubmed/11021840
PubMed	11752216	http://www.ncbi.nlm.nih.gov/pubmed/11752216
PubMed	12697997	http://www.ncbi.nlm.nih.gov/pubmed/12697997
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15531379	http://www.ncbi.nlm.nih.gov/pubmed/15531379
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	25282151	http://www.ncbi.nlm.nih.gov/pubmed/25282151
Reactome	R-HSA-629594	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-629594
RefSeq	NP_060051	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060051
SMR	Q9UGM1	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9UGM1
STRING	9606.ENSP00000312663	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000312663&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc003gva	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003gva&org=rat
UniGene	Hs.272278	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.272278
UniProtKB	ACHA9_HUMAN	http://www.uniprot.org/uniprot/ACHA9_HUMAN
UniProtKB-AC	Q9UGM1	http://www.uniprot.org/uniprot/Q9UGM1
charge	swissprot:ACHA9_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ACHA9_HUMAN
eggNOG	ENOG410XQGR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQGR
eggNOG	KOG3645	http://eggnogapi.embl.de/nog_data/html/tree/KOG3645
epestfind	swissprot:ACHA9_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ACHA9_HUMAN
garnier	swissprot:ACHA9_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ACHA9_HUMAN
helixturnhelix	swissprot:ACHA9_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACHA9_HUMAN
hmoment	swissprot:ACHA9_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ACHA9_HUMAN
iep	swissprot:ACHA9_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ACHA9_HUMAN
inforesidue	swissprot:ACHA9_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ACHA9_HUMAN
neXtProt	NX_Q9UGM1	http://www.nextprot.org/db/entry/NX_Q9UGM1
octanol	swissprot:ACHA9_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ACHA9_HUMAN
pepcoil	swissprot:ACHA9_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ACHA9_HUMAN
pepdigest	swissprot:ACHA9_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ACHA9_HUMAN
pepinfo	swissprot:ACHA9_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ACHA9_HUMAN
pepnet	swissprot:ACHA9_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ACHA9_HUMAN
pepstats	swissprot:ACHA9_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ACHA9_HUMAN
pepwheel	swissprot:ACHA9_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ACHA9_HUMAN
pepwindow	swissprot:ACHA9_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ACHA9_HUMAN
sigcleave	swissprot:ACHA9_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ACHA9_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCIP1_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=KCHIP1b; IsoId=Q9NZI2-1; Sequence=Displayed; Name=2; Synonyms=KCHIP1a; IsoId=Q9NZI2-2; Sequence=VSP_015044, VSP_047686; Name=3; IsoId=Q9NZI2-3; Sequence=VSP_015043; Name=4; IsoId=Q9NZI2-4; Sequence=VSP_041511; Name=5; IsoId=Q9NZI2-5; Sequence=VSP_015044, VSP_047687; 
# AltName	KCIP1_HUMAN	A-type potassium channel modulatory protein 1
# AltName	KCIP1_HUMAN	Potassium channel-interacting protein 1
# AltName	KCIP1_HUMAN	Vesicle APC-binding protein
# BioGrid	119044	5
# CCDS	CCDS34285	-. [Q9NZI2-4]
# CCDS	CCDS34286	-. [Q9NZI2-1]
# CCDS	CCDS64312	-. [Q9NZI2-5]
# CCDS	CCDS64313	-. [Q9NZI2-3]
# CDD	cd00051	EFh; 2
# ChiTaRS	KCNIP1	human
# Ensembl	ENST00000377360	ENSP00000366577; ENSG00000182132. [Q9NZI2-4]
# Ensembl	ENST00000411494	ENSP00000395323; ENSG00000182132. [Q9NZI2-1]
# Ensembl	ENST00000434108	ENSP00000414886; ENSG00000182132. [Q9NZI2-5]
# Ensembl	ENST00000520740	ENSP00000431102; ENSG00000182132. [Q9NZI2-3]
# ExpressionAtlas	Q9NZI2	baseline and differential
# FUNCTION	KCIP1_HUMAN	Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Increases the presence of KCND2 at the cell surface. {ECO 0000269|PubMed 10676964, ECO 0000269|PubMed 11423117, ECO 0000269|PubMed 12829703, ECO 0000269|PubMed 17187064}. 
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IDA:UniProtKB.
# GO_component	GO:0030425	dendrite; IEA:UniProtKB-SubCell.
# GO_component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane; IDA:UniProtKB.
# GO_function	GO:0005244	voltage-gated ion channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0005267	potassium channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0005509	calcium ion binding; IDA:UniProtKB.
# GO_function	GO:0015459	potassium channel regulator activity; IDA:UniProtKB.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:1901379	regulation of potassium ion transmembrane transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.10.238.10	-; 3.
# Genevisible	Q9NZI2	HS
# HGNC	HGNC:15521	KCNIP1
# INTERACTION	KCIP1_HUMAN	Q9NZV8 KCND2; NbExp=4; IntAct=EBI-2120635, EBI-1646745; Q9UK17 KCND3; NbExp=3; IntAct=EBI-2120635, EBI-9825212; Q9NS61-3 KCNIP2; NbExp=4; IntAct=EBI-2120635, EBI-1053010; 
# IntAct	Q9NZI2	3
# InterPro	IPR002048	EF_hand_dom
# InterPro	IPR011992	EF-hand-dom_pair
# InterPro	IPR018247	EF_Hand_1_Ca_BS
# InterPro	IPR028846	Recoverin
# MIM	604660	gene
# Organism	KCIP1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR23055	PTHR23055
# PDB	1S1E	X-ray; 2.30 A; A=1-227
# PDB	2I2R	X-ray; 3.35 A; E/F/G/H/M/N/O/P=48-227
# PDB	2NZ0	X-ray; 3.20 A; A/C=49-227
# PROSITE	PS00018	EF_HAND_1; 2
# PROSITE	PS50222	EF_HAND_2; 3
# Pfam	PF13499	EF-hand_7
# Pfam	PF13833	EF-hand_8
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-5576894	Phase 1 - inactivation of fast Na+ channels
# RecName	KCIP1_HUMAN	Kv channel-interacting protein 1
# RefSeq	NP_001030009	NM_001034837.2. [Q9NZI2-1]
# RefSeq	NP_001030010	NM_001034838.2. [Q9NZI2-4]
# RefSeq	NP_001265268	NM_001278339.1. [Q9NZI2-5]
# RefSeq	NP_001265269	NM_001278340.1. [Q9NZI2-3]
# RefSeq	NP_055407	NM_014592.3
# RefSeq	XP_016864896	XM_017009407.1. [Q9NZI2-4]
# SIMILARITY	Belongs to the recoverin family. {ECO	0000305}. 
# SIMILARITY	Contains 4 EF-hand domains. {ECO:0000255|PROSITE- ProRule	PRU00448}.
# SMART	SM00054	EFh; 3
# SUBCELLULAR LOCATION	KCIP1_HUMAN	Cell membrane {ECO 0000269|PubMed 10676964}; Peripheral membrane protein {ECO 0000305|PubMed 10676964}. Cytoplasm {ECO 0000269|PubMed 10676964}. Cell projection, dendrite {ECO 0000250|UniProtKB Q8R426}. 
# SUBUNIT	KCIP1_HUMAN	Component of heteromultimeric potassium channels. Identified in potassium channel complexes containing KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10 (By similarity). Part of a heterooctamer composed of the tetrameric channel and four KCNIP1 chains. Interacts with KCND3 and the N- terminal domain of KCND2. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2. Self-associates to form homodimers and homotetramers. Interacts with KCNIP2 isoform 3 in a calcium-dependent manner. Interacts with Naja atra venom CTX3. {ECO 0000250|UniProtKB Q9JJ57, ECO 0000269|PubMed 10676964, ECO 0000269|PubMed 14980207, ECO 0000269|PubMed 15184042, ECO 0000269|PubMed 15358149, ECO 0000269|PubMed 17057713, ECO 0000269|PubMed 17187064}. 
# SUPFAM	SSF47473	SSF47473
# TISSUE SPECIFICITY	KCIP1_HUMAN	Isoform 1 and isoform 2 are expressed in brain and kidney. Isoform 1 is also expressed in liver, pancreas, skeletal muscle, small intestine and testis. Isoform 2 is also expressed in lung, pancreas, leukocytes, prostate and thymus. 
# UCSC	uc003map	human. [Q9NZI2-1]
# eggNOG	COG5126	LUCA
# eggNOG	KOG0044	Eukaryota
BLAST	swissprot:KCIP1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCIP1_HUMAN
BioCyc	ZFISH:G66-33457-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33457-MONOMER
COXPRESdb	30820	http://coxpresdb.jp/data/gene/30820.shtml
CleanEx	HS_KCNIP1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNIP1
DIP	DIP-29246N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29246N
DOI	10.1016/S0014-5793(01)02560-1	http://dx.doi.org/10.1016/S0014-5793(01)02560-1
DOI	10.1016/S0896-6273(04)00049-2	http://dx.doi.org/10.1016/S0896-6273(04)00049-2
DOI	10.1016/S1044-7431(03)00174-X	http://dx.doi.org/10.1016/S1044-7431(03)00174-X
DOI	10.1016/j.bbrc.2004.05.064	http://dx.doi.org/10.1016/j.bbrc.2004.05.064
DOI	10.1016/j.bbrc.2004.07.006	http://dx.doi.org/10.1016/j.bbrc.2004.07.006
DOI	10.1016/j.ygeno.2005.07.001	http://dx.doi.org/10.1016/j.ygeno.2005.07.001
DOI	10.1038/35000592	http://dx.doi.org/10.1038/35000592
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/nn1822	http://dx.doi.org/10.1038/nn1822
DOI	10.1038/nsmb1164	http://dx.doi.org/10.1038/nsmb1164
DOI	10.1074/jbc.M306142200	http://dx.doi.org/10.1074/jbc.M306142200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC008619	http://www.ebi.ac.uk/ena/data/view/AC008619
EMBL	AC008719	http://www.ebi.ac.uk/ena/data/view/AC008719
EMBL	AC027306	http://www.ebi.ac.uk/ena/data/view/AC027306
EMBL	AC027312	http://www.ebi.ac.uk/ena/data/view/AC027312
EMBL	AC034199	http://www.ebi.ac.uk/ena/data/view/AC034199
EMBL	AC113432	http://www.ebi.ac.uk/ena/data/view/AC113432
EMBL	AC134820	http://www.ebi.ac.uk/ena/data/view/AC134820
EMBL	AF199597	http://www.ebi.ac.uk/ena/data/view/AF199597
EMBL	AK301775	http://www.ebi.ac.uk/ena/data/view/AK301775
EMBL	AY170821	http://www.ebi.ac.uk/ena/data/view/AY170821
EMBL	AY780424	http://www.ebi.ac.uk/ena/data/view/AY780424
EMBL	BC050375	http://www.ebi.ac.uk/ena/data/view/BC050375
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	DQ148476	http://www.ebi.ac.uk/ena/data/view/DQ148476
EMBL	DQ148477	http://www.ebi.ac.uk/ena/data/view/DQ148477
EMBL	DQ148478	http://www.ebi.ac.uk/ena/data/view/DQ148478
EMBL	DQ148479	http://www.ebi.ac.uk/ena/data/view/DQ148479
Ensembl	ENST00000377360	http://www.ensembl.org/id/ENST00000377360
Ensembl	ENST00000411494	http://www.ensembl.org/id/ENST00000411494
Ensembl	ENST00000434108	http://www.ensembl.org/id/ENST00000434108
Ensembl	ENST00000520740	http://www.ensembl.org/id/ENST00000520740
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0031234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031234
GO_function	GO:0005244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005244
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0015459	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015459
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:1901379	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901379
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.10.238.10	http://www.cathdb.info/version/latest/superfamily/1.10.238.10
GeneCards	KCNIP1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNIP1
GeneID	30820	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=30820
GeneTree	ENSGT00760000118820	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118820
HGNC	HGNC:15521	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:15521
HOGENOM	HOG000233019	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233019&db=HOGENOM6
HOVERGEN	HBG108179	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108179&db=HOVERGEN
HPA	HPA022864	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA022864
InParanoid	Q9NZI2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NZI2
IntAct	Q9NZI2	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NZI2*
InterPro	IPR002048	http://www.ebi.ac.uk/interpro/entry/IPR002048
InterPro	IPR011992	http://www.ebi.ac.uk/interpro/entry/IPR011992
InterPro	IPR018247	http://www.ebi.ac.uk/interpro/entry/IPR018247
InterPro	IPR028846	http://www.ebi.ac.uk/interpro/entry/IPR028846
Jabion	30820	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=30820
KEGG_Gene	hsa:30820	http://www.genome.jp/dbget-bin/www_bget?hsa:30820
MIM	604660	http://www.ncbi.nlm.nih.gov/omim/604660
OMA	TDAPKQH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TDAPKQH
OrthoDB	EOG091G11T4	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G11T4
PANTHER	PTHR23055	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23055
PDB	1S1E	http://www.ebi.ac.uk/pdbe-srv/view/entry/1S1E
PDB	2I2R	http://www.ebi.ac.uk/pdbe-srv/view/entry/2I2R
PDB	2NZ0	http://www.ebi.ac.uk/pdbe-srv/view/entry/2NZ0
PDBsum	1S1E	http://www.ebi.ac.uk/pdbsum/1S1E
PDBsum	2I2R	http://www.ebi.ac.uk/pdbsum/2I2R
PDBsum	2NZ0	http://www.ebi.ac.uk/pdbsum/2NZ0
PROSITE	PS00018	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00018
PROSITE	PS50222	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50222
PSORT	swissprot:KCIP1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCIP1_HUMAN
PSORT-B	swissprot:KCIP1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCIP1_HUMAN
PSORT2	swissprot:KCIP1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCIP1_HUMAN
Pfam	PF13499	http://pfam.xfam.org/family/PF13499
Pfam	PF13833	http://pfam.xfam.org/family/PF13833
PharmGKB	PA30041	http://www.pharmgkb.org/do/serve?objId=PA30041&objCls=Gene
Phobius	swissprot:KCIP1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCIP1_HUMAN
PhylomeDB	Q9NZI2	http://phylomedb.org/?seqid=Q9NZI2
ProteinModelPortal	Q9NZI2	http://www.proteinmodelportal.org/query/uniprot/Q9NZI2
PubMed	10676964	http://www.ncbi.nlm.nih.gov/pubmed/10676964
PubMed	11423117	http://www.ncbi.nlm.nih.gov/pubmed/11423117
PubMed	12829703	http://www.ncbi.nlm.nih.gov/pubmed/12829703
PubMed	14572458	http://www.ncbi.nlm.nih.gov/pubmed/14572458
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	14980207	http://www.ncbi.nlm.nih.gov/pubmed/14980207
PubMed	15184042	http://www.ncbi.nlm.nih.gov/pubmed/15184042
PubMed	15358149	http://www.ncbi.nlm.nih.gov/pubmed/15358149
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16112838	http://www.ncbi.nlm.nih.gov/pubmed/16112838
PubMed	17057713	http://www.ncbi.nlm.nih.gov/pubmed/17057713
PubMed	17187064	http://www.ncbi.nlm.nih.gov/pubmed/17187064
Reactome	R-HSA-5576894	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576894
RefSeq	NP_001030009	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001030009
RefSeq	NP_001030010	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001030010
RefSeq	NP_001265268	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001265268
RefSeq	NP_001265269	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001265269
RefSeq	NP_055407	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055407
RefSeq	XP_016864896	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016864896
SMART	SM00054	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00054
SMR	Q9NZI2	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9NZI2
STRING	9606.ENSP00000395323	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000395323&targetmode=cogs
SUPFAM	SSF47473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47473
UCSC	uc003map	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003map&org=rat
UniGene	Hs.484111	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.484111
UniProtKB	KCIP1_HUMAN	http://www.uniprot.org/uniprot/KCIP1_HUMAN
UniProtKB-AC	Q9NZI2	http://www.uniprot.org/uniprot/Q9NZI2
charge	swissprot:KCIP1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCIP1_HUMAN
eggNOG	COG5126	http://eggnogapi.embl.de/nog_data/html/tree/COG5126
eggNOG	KOG0044	http://eggnogapi.embl.de/nog_data/html/tree/KOG0044
epestfind	swissprot:KCIP1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCIP1_HUMAN
garnier	swissprot:KCIP1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCIP1_HUMAN
helixturnhelix	swissprot:KCIP1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCIP1_HUMAN
hmoment	swissprot:KCIP1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCIP1_HUMAN
iep	swissprot:KCIP1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCIP1_HUMAN
inforesidue	swissprot:KCIP1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCIP1_HUMAN
neXtProt	NX_Q9NZI2	http://www.nextprot.org/db/entry/NX_Q9NZI2
octanol	swissprot:KCIP1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCIP1_HUMAN
pepcoil	swissprot:KCIP1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCIP1_HUMAN
pepdigest	swissprot:KCIP1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCIP1_HUMAN
pepinfo	swissprot:KCIP1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCIP1_HUMAN
pepnet	swissprot:KCIP1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCIP1_HUMAN
pepstats	swissprot:KCIP1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCIP1_HUMAN
pepwheel	swissprot:KCIP1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCIP1_HUMAN
pepwindow	swissprot:KCIP1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCIP1_HUMAN
sigcleave	swissprot:KCIP1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCIP1_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	123605	54
# CAUTION	It is uncertain whether Met-1 or Met-5 is the initiator. {ECO	0000305}.
# ChiTaRS	SFXN3	human
# Ensembl	ENST00000224807	ENSP00000224807; ENSG00000107819
# ExpressionAtlas	Q9BWM7	baseline and differential
# FUNCTION	SFXN3_HUMAN	Potential iron transporter. 
# GO_component	GO:0005739	mitochondrion; IDA:HPA.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0031966	mitochondrial membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0015075	ion transmembrane transporter activity; IEA:InterPro.
# GO_process	GO:0055072	iron ion homeostasis; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0042592	homeostatic process
# Genevisible	Q9BWM7	HS
# HGNC	HGNC:16087	SFXN3
# IntAct	Q9BWM7	18
# InterPro	IPR004686	Mtc
# MIM	615571	gene
# Organism	SFXN3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11153	PTHR11153
# Pfam	PF03820	Mtc
# Proteomes	UP000005640	Chromosome 10
# RecName	SFXN3_HUMAN	Sideroflexin-3
# RefSeq	NP_112233	NM_030971.3
# SIMILARITY	Belongs to the sideroflexin family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	SFXN3_HUMAN	Mitochondrion membrane {ECO 0000269|Ref.4}; Multi-pass membrane protein {ECO 0000269|Ref.4}. 
# TIGRFAMs	TIGR00798	mtc
# UCSC	uc057vma	human
# eggNOG	ENOG410YU8V	LUCA
# eggNOG	KOG3767	Eukaryota
BLAST	swissprot:SFXN3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SFXN3_HUMAN
BioCyc	ZFISH:ENSG00000107819-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000107819-MONOMER
COXPRESdb	81855	http://coxpresdb.jp/data/gene/81855.shtml
CleanEx	HS_SFXN3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SFXN3
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1038/nature02462	http://dx.doi.org/10.1038/nature02462
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AK074707	http://www.ebi.ac.uk/ena/data/view/AK074707
EMBL	AL133215	http://www.ebi.ac.uk/ena/data/view/AL133215
EMBL	BC000124	http://www.ebi.ac.uk/ena/data/view/BC000124
Ensembl	ENST00000224807	http://www.ensembl.org/id/ENST00000224807
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0031966	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031966
GO_function	GO:0015075	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015075
GO_process	GO:0055072	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GeneCards	SFXN3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SFXN3
GeneID	81855	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81855
GeneTree	ENSGT00390000002026	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002026
HGNC	HGNC:16087	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16087
HOGENOM	HOG000203440	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000203440&db=HOGENOM6
HOVERGEN	HBG056083	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG056083&db=HOVERGEN
HPA	HPA008028	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA008028
HPA	HPA048105	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA048105
InParanoid	Q9BWM7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9BWM7
IntAct	Q9BWM7	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9BWM7*
InterPro	IPR004686	http://www.ebi.ac.uk/interpro/entry/IPR004686
Jabion	81855	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=81855
KEGG_Gene	hsa:81855	http://www.genome.jp/dbget-bin/www_bget?hsa:81855
MIM	615571	http://www.ncbi.nlm.nih.gov/omim/615571
OMA	IPPLIMD	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IPPLIMD
OrthoDB	EOG091G0BOU	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0BOU
PANTHER	PTHR11153	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11153
PSORT	swissprot:SFXN3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SFXN3_HUMAN
PSORT-B	swissprot:SFXN3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SFXN3_HUMAN
PSORT2	swissprot:SFXN3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SFXN3_HUMAN
Pfam	PF03820	http://pfam.xfam.org/family/PF03820
PharmGKB	PA38092	http://www.pharmgkb.org/do/serve?objId=PA38092&objCls=Gene
Phobius	swissprot:SFXN3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SFXN3_HUMAN
PhylomeDB	Q9BWM7	http://phylomedb.org/?seqid=Q9BWM7
ProteinModelPortal	Q9BWM7	http://www.proteinmodelportal.org/query/uniprot/Q9BWM7
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15164054	http://www.ncbi.nlm.nih.gov/pubmed/15164054
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
RefSeq	NP_112233	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_112233
STRING	9606.ENSP00000224807	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000224807&targetmode=cogs
TIGRFAMs	TIGR00798	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00798
UCSC	uc057vma	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc057vma&org=rat
UniGene	Hs.283844	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.283844
UniProtKB	SFXN3_HUMAN	http://www.uniprot.org/uniprot/SFXN3_HUMAN
UniProtKB-AC	Q9BWM7	http://www.uniprot.org/uniprot/Q9BWM7
charge	swissprot:SFXN3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SFXN3_HUMAN
eggNOG	ENOG410YU8V	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YU8V
eggNOG	KOG3767	http://eggnogapi.embl.de/nog_data/html/tree/KOG3767
epestfind	swissprot:SFXN3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SFXN3_HUMAN
garnier	swissprot:SFXN3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SFXN3_HUMAN
helixturnhelix	swissprot:SFXN3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SFXN3_HUMAN
hmoment	swissprot:SFXN3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SFXN3_HUMAN
iep	swissprot:SFXN3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SFXN3_HUMAN
inforesidue	swissprot:SFXN3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SFXN3_HUMAN
neXtProt	NX_Q9BWM7	http://www.nextprot.org/db/entry/NX_Q9BWM7
octanol	swissprot:SFXN3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SFXN3_HUMAN
pepcoil	swissprot:SFXN3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SFXN3_HUMAN
pepdigest	swissprot:SFXN3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SFXN3_HUMAN
pepinfo	swissprot:SFXN3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SFXN3_HUMAN
pepnet	swissprot:SFXN3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SFXN3_HUMAN
pepstats	swissprot:SFXN3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SFXN3_HUMAN
pepwheel	swissprot:SFXN3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SFXN3_HUMAN
pepwindow	swissprot:SFXN3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SFXN3_HUMAN
sigcleave	swissprot:SFXN3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SFXN3_HUMAN
## Database	ID	URL or Descriptions
# AltName	RAP1A_HUMAN	C21KG
# AltName	RAP1A_HUMAN	G-22K
# AltName	RAP1A_HUMAN	GTP-binding protein smg p21A
# AltName	RAP1A_HUMAN	Ras-related protein Krev-1
# BioGrid	111841	71
# ChiTaRS	RAP1A	human
# ENZYME REGULATION	RAP1A_HUMAN	Activated by guanine nucleotide-exchange factors (GEF) EPAC and EPAC2 in a cAMP-dependent manner, and GFR. 
# Ensembl	ENST00000356415	ENSP00000348786; ENSG00000116473
# Ensembl	ENST00000369709	ENSP00000358723; ENSG00000116473
# ExpressionAtlas	P62834	baseline and differential
# FUNCTION	RAP1A_HUMAN	Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. {ECO 0000269|PubMed 17916086, ECO 0000269|PubMed 21840392}. 
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005769	early endosome; ISS:UniProtKB.
# GO_component	GO:0005770	late endosome; ISS:UniProtKB.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0030054	cell junction; ISS:UniProtKB.
# GO_component	GO:0032045	guanyl-nucleotide exchange factor complex; IEA:Ensembl.
# GO_component	GO:0043005	neuron projection; IEA:Ensembl.
# GO_component	GO:0043209	myelin sheath; IEA:Ensembl.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0003924	GTPase activity; TAS:ProtInc.
# GO_function	GO:0005525	GTP binding; IEA:UniProtKB-KW.
# GO_function	GO:0008565	protein transporter activity; IDA:UniProtKB.
# GO_function	GO:0017034	Rap guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
# GO_function	GO:0032403	protein complex binding; IDA:UniProtKB.
# GO_process	GO:0000186	activation of MAPKK activity; TAS:Reactome.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0010976	positive regulation of neuron projection development; ISS:UniProtKB.
# GO_process	GO:0015031	protein transport; IDA:UniProtKB.
# GO_process	GO:0032486	Rap protein signal transduction; IMP:UniProtKB.
# GO_process	GO:0032966	negative regulation of collagen biosynthetic process; IEA:Ensembl.
# GO_process	GO:0035690	cellular response to drug; IEA:Ensembl.
# GO_process	GO:0038180	nerve growth factor signaling pathway; ISS:UniProtKB.
# GO_process	GO:0043547	positive regulation of GTPase activity; ISS:UniProtKB.
# GO_process	GO:0045860	positive regulation of protein kinase activity; ISS:UniProtKB.
# GO_process	GO:0046326	positive regulation of glucose import; IEA:Ensembl.
# GO_process	GO:0050766	positive regulation of phagocytosis; IEA:Ensembl.
# GO_process	GO:0050796	regulation of insulin secretion; TAS:Reactome.
# GO_process	GO:0061028	establishment of endothelial barrier; IMP:UniProtKB.
# GO_process	GO:0070374	positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
# GO_process	GO:0071320	cellular response to cAMP; IDA:UniProtKB.
# GO_process	GO:0071333	cellular response to glucose stimulus; IEA:Ensembl.
# GO_process	GO:0097327	response to antineoplastic agent; IEA:Ensembl.
# GO_process	GO:0097421	liver regeneration; IEA:Ensembl.
# GO_process	GO:1901888	regulation of cell junction assembly; IMP:UniProtKB.
# GO_process	GO:1990090	cellular response to nerve growth factor stimulus; ISS:UniProtKB.
# GO_process	GO:2000301	negative regulation of synaptic vesicle exocytosis; IEA:Ensembl.
# GO_process	GO:2001214	positive regulation of vasculogenesis; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0003924	GTPase activity
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# Gene3D	3.40.50.300	-; 1.
# Genevisible	P62834	HS
# HGNC	HGNC:9855	RAP1A
# INTERACTION	RAP1A_HUMAN	P04049 RAF1; NbExp=2; IntAct=EBI-491414, EBI-365996; Q8WWW0-2 RASSF5; NbExp=3; IntAct=EBI-491414, EBI-960502; Q5EBH1 Rassf5 (xeno); NbExp=2; IntAct=EBI-491414, EBI-960530; 
# IntAct	P62834	23
# InterPro	IPR001806	Small_GTPase
# InterPro	IPR005225	Small_GTP-bd_dom
# InterPro	IPR020849	Small_GTPase_Ras
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04031	 GTP-binding proteins
# KEGG_Pathway	ko04010	MAPK signaling pathway
# KEGG_Pathway	ko04062	Chemokine signaling pathway
# KEGG_Pathway	ko04510	Focal adhesion
# KEGG_Pathway	ko04670	Leukocyte transendothelial migration
# KEGG_Pathway	ko04720	Long-term potentiation
# KEGG_Pathway	ko04722	Neurotrophin signaling pathway
# KEGG_Pathway	ko04972	Pancreatic secretion
# KEGG_Pathway	ko05211	Renal cell carcinoma
# MIM	179520	gene
# Organism	RAP1A_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR24070	PTHR24070
# PDB	1C1Y	X-ray; 1.90 A; A=1-167
# PDB	1GUA	X-ray; 2.00 A; A=1-167
# PDB	3KUC	X-ray; 1.92 A; A=1-167
# PDB	4KVG	X-ray; 1.65 A; A/C=1-167
# PIR	A32342	A32342
# PROSITE	PS51421	RAS
# Pfam	PF00071	Ras
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-170968	Frs2-mediated activation
# Reactome	R-HSA-170984	ARMS-mediated activation
# Reactome	R-HSA-354192	Integrin alphaIIb beta3 signaling
# Reactome	R-HSA-354194:GRB2	SOS provides linkage to MAPK signaling for Integrins
# Reactome	R-HSA-372708	p130Cas linkage to MAPK signaling for integrins
# Reactome	R-HSA-381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
# Reactome	R-HSA-392517	Rap1 signalling
# Reactome	R-HSA-5674135	MAP2K and MAPK activation
# Reactome	R-HSA-6798695	Neutrophil degranulation
# Reactome	R-HSA-6802946	Signaling by moderate kinase activity BRAF mutants
# Reactome	R-HSA-6802948	Signaling by high-kinase activity BRAF mutants
# Reactome	R-HSA-6802949	Signaling by RAS mutants
# Reactome	R-HSA-6802952	Signaling by BRAF and RAF fusions
# Reactome	R-HSA-6802955	Paradoxical activation of RAF signaling by kinase inactive BRAF
# Reactome	R-HSA-8875555	MET activates RAP1 and RAC1
# RecName	RAP1A_HUMAN	Ras-related protein Rap-1A
# RefSeq	NP_001010935	NM_001010935.2
# RefSeq	NP_001278825	NM_001291896.1
# RefSeq	NP_002875	NM_002884.3
# RefSeq	XP_016857451	XM_017001962.1
# RefSeq	XP_016857452	XM_017001963.1
# RefSeq	XP_016857453	XM_017001964.1
# SEQUENCE CAUTION	Sequence=CAB55685.2; Type=Erroneous gene model prediction; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the small GTPase superfamily. Ras family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	RAP1A_HUMAN	Cell membrane {ECO 0000269|PubMed 11359771}; Lipid-anchor {ECO 0000269|PubMed 11359771}. Cytoplasm {ECO 0000269|PubMed 11359771}. Cytoplasm, perinuclear region {ECO 0000269|PubMed 11359771}. Cell junction {ECO 0000250}. Early endosome {ECO 0000250}. Note=Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Localized with RAPGEF2 at cell-cell junctions (By similarity). Colocalized with RAPGEF2 in the perinuclear region. {ECO 0000250}. 
# SUBUNIT	RAP1A_HUMAN	Found in a complex, at least composed of ITGB1BP1, KRIT1 and RAP1A. Interacts (active GTP-bound form preferentially) with KRIT1 (via C-terminus FERM domain); the interaction does not induce the opening conformation of KRIT1. In its GTP-bound form interacts with PLCE1 and RADIL. Interacts with SGSM1, SGSM2 and SGSM3. Interacts (via GTP-bound active form) with RAPGEF2 (via Ras-associating domain). {ECO 0000269|PubMed 10608844, ECO 0000269|PubMed 11022048, ECO 0000269|PubMed 11359771, ECO 0000269|PubMed 12444546, ECO 0000269|PubMed 17509819, ECO 0000269|PubMed 17704304, ECO 0000269|PubMed 17916086}. 
# SUPFAM	SSF52540	SSF52540
# TIGRFAMs	TIGR00231	small_GTP
# UCSC	uc001ebi	human
# WEB RESOURCE	RAP1A_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/RAP1AID272.html";
# eggNOG	COG1100	LUCA
# eggNOG	KOG0395	Eukaryota
BLAST	swissprot:RAP1A_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:RAP1A_HUMAN
BioCyc	ZFISH:ENSG00000116473-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000116473-MONOMER
COXPRESdb	5906	http://coxpresdb.jp/data/gene/5906.shtml
CleanEx	HS_RAP1A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_RAP1A
DIP	DIP-29106N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29106N
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/S0006-291X(88)80302-4	http://dx.doi.org/10.1016/S0006-291X(88)80302-4
DOI	10.1016/j.cellsig.2011.07.022	http://dx.doi.org/10.1016/j.cellsig.2011.07.022
DOI	10.1016/j.ygeno.2007.03.013	http://dx.doi.org/10.1016/j.ygeno.2007.03.013
DOI	10.1038/375554a0	http://dx.doi.org/10.1038/375554a0
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/nsb0896-723	http://dx.doi.org/10.1038/nsb0896-723
DOI	10.1038/sj.onc.1206003	http://dx.doi.org/10.1038/sj.onc.1206003
DOI	10.1074/jbc.274.53.37815	http://dx.doi.org/10.1074/jbc.274.53.37815
DOI	10.1074/jbc.M008324200	http://dx.doi.org/10.1074/jbc.M008324200
DOI	10.1074/jbc.M101737200	http://dx.doi.org/10.1074/jbc.M101737200
DOI	10.1101/gad.1561507	http://dx.doi.org/10.1101/gad.1561507
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1742-4658.2007.06068.x	http://dx.doi.org/10.1111/j.1742-4658.2007.06068.x
DOI	10.1128/MCB.11.3.1523	http://dx.doi.org/10.1128/MCB.11.3.1523
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF493912	http://www.ebi.ac.uk/ena/data/view/AF493912
EMBL	AL049557	http://www.ebi.ac.uk/ena/data/view/AL049557
EMBL	BC014086	http://www.ebi.ac.uk/ena/data/view/BC014086
EMBL	M22995	http://www.ebi.ac.uk/ena/data/view/M22995
EMBL	X12533	http://www.ebi.ac.uk/ena/data/view/X12533
Ensembl	ENST00000356415	http://www.ensembl.org/id/ENST00000356415
Ensembl	ENST00000369709	http://www.ensembl.org/id/ENST00000369709
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005769	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005769
GO_component	GO:0005770	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005770
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0032045	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032045
GO_component	GO:0043005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043005
GO_component	GO:0043209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043209
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0003924	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924
GO_function	GO:0005525	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0017034	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017034
GO_function	GO:0032403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032403
GO_process	GO:0000186	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000186
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0010976	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010976
GO_process	GO:0015031	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031
GO_process	GO:0032486	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032486
GO_process	GO:0032966	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032966
GO_process	GO:0035690	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035690
GO_process	GO:0038180	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0038180
GO_process	GO:0043547	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043547
GO_process	GO:0045860	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045860
GO_process	GO:0046326	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046326
GO_process	GO:0050766	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050766
GO_process	GO:0050796	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050796
GO_process	GO:0061028	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061028
GO_process	GO:0070374	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070374
GO_process	GO:0071320	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071320
GO_process	GO:0071333	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071333
GO_process	GO:0097327	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097327
GO_process	GO:0097421	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097421
GO_process	GO:1901888	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901888
GO_process	GO:1990090	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990090
GO_process	GO:2000301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000301
GO_process	GO:2001214	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001214
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0003924	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	RAP1A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=RAP1A
GeneID	5906	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5906
GeneTree	ENSGT00860000133678	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00860000133678
HGNC	HGNC:9855	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:9855
HOGENOM	HOG000233973	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233973&db=HOGENOM6
HOVERGEN	HBG009351	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG009351&db=HOVERGEN
HPA	CAB018335	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB018335
InParanoid	P62834	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P62834
IntAct	P62834	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P62834*
InterPro	IPR001806	http://www.ebi.ac.uk/interpro/entry/IPR001806
InterPro	IPR005225	http://www.ebi.ac.uk/interpro/entry/IPR005225
InterPro	IPR020849	http://www.ebi.ac.uk/interpro/entry/IPR020849
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	5906	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=5906
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04031	http://www.genome.jp/dbget-bin/www_bget?ko04031
KEGG_Gene	hsa:5906	http://www.genome.jp/dbget-bin/www_bget?hsa:5906
KEGG_Orthology	KO:K04353	http://www.genome.jp/dbget-bin/www_bget?KO:K04353
KEGG_Pathway	ko04010	http://www.genome.jp/kegg-bin/show_pathway?ko04010
KEGG_Pathway	ko04062	http://www.genome.jp/kegg-bin/show_pathway?ko04062
KEGG_Pathway	ko04510	http://www.genome.jp/kegg-bin/show_pathway?ko04510
KEGG_Pathway	ko04670	http://www.genome.jp/kegg-bin/show_pathway?ko04670
KEGG_Pathway	ko04720	http://www.genome.jp/kegg-bin/show_pathway?ko04720
KEGG_Pathway	ko04722	http://www.genome.jp/kegg-bin/show_pathway?ko04722
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
KEGG_Pathway	ko05211	http://www.genome.jp/kegg-bin/show_pathway?ko05211
MIM	179520	http://www.ncbi.nlm.nih.gov/omim/179520
MINT	MINT-1509313	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1509313
OMA	ARSFNSA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ARSFNSA
OrthoDB	EOG091G0OOG	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0OOG
PANTHER	PTHR24070	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24070
PDB	1C1Y	http://www.ebi.ac.uk/pdbe-srv/view/entry/1C1Y
PDB	1GUA	http://www.ebi.ac.uk/pdbe-srv/view/entry/1GUA
PDB	3KUC	http://www.ebi.ac.uk/pdbe-srv/view/entry/3KUC
PDB	4KVG	http://www.ebi.ac.uk/pdbe-srv/view/entry/4KVG
PDBsum	1C1Y	http://www.ebi.ac.uk/pdbsum/1C1Y
PDBsum	1GUA	http://www.ebi.ac.uk/pdbsum/1GUA
PDBsum	3KUC	http://www.ebi.ac.uk/pdbsum/3KUC
PDBsum	4KVG	http://www.ebi.ac.uk/pdbsum/4KVG
PROSITE	PS51421	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51421
PSORT	swissprot:RAP1A_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:RAP1A_HUMAN
PSORT-B	swissprot:RAP1A_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:RAP1A_HUMAN
PSORT2	swissprot:RAP1A_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:RAP1A_HUMAN
Pfam	PF00071	http://pfam.xfam.org/family/PF00071
PharmGKB	PA34217	http://www.pharmgkb.org/do/serve?objId=PA34217&objCls=Gene
Phobius	swissprot:RAP1A_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:RAP1A_HUMAN
PhylomeDB	P62834	http://phylomedb.org/?seqid=P62834
ProteinModelPortal	P62834	http://www.proteinmodelportal.org/query/uniprot/P62834
PubMed	10608844	http://www.ncbi.nlm.nih.gov/pubmed/10608844
PubMed	11022048	http://www.ncbi.nlm.nih.gov/pubmed/11022048
PubMed	11359771	http://www.ncbi.nlm.nih.gov/pubmed/11359771
PubMed	12444546	http://www.ncbi.nlm.nih.gov/pubmed/12444546
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17509819	http://www.ncbi.nlm.nih.gov/pubmed/17509819
PubMed	17704304	http://www.ncbi.nlm.nih.gov/pubmed/17704304
PubMed	17916086	http://www.ncbi.nlm.nih.gov/pubmed/17916086
PubMed	1899909	http://www.ncbi.nlm.nih.gov/pubmed/1899909
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21840392	http://www.ncbi.nlm.nih.gov/pubmed/21840392
PubMed	2507536	http://www.ncbi.nlm.nih.gov/pubmed/2507536
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	3045729	http://www.ncbi.nlm.nih.gov/pubmed/3045729
PubMed	3141412	http://www.ncbi.nlm.nih.gov/pubmed/3141412
PubMed	3144274	http://www.ncbi.nlm.nih.gov/pubmed/3144274
PubMed	7791872	http://www.ncbi.nlm.nih.gov/pubmed/7791872
PubMed	8756332	http://www.ncbi.nlm.nih.gov/pubmed/8756332
Reactome	R-HSA-170968	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-170968
Reactome	R-HSA-170984	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-170984
Reactome	R-HSA-354192	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-354192
Reactome	R-HSA-354194	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-354194
Reactome	R-HSA-372708	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-372708
Reactome	R-HSA-381676	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-381676
Reactome	R-HSA-392517	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-392517
Reactome	R-HSA-5674135	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5674135
Reactome	R-HSA-6798695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6798695
Reactome	R-HSA-6802946	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6802946
Reactome	R-HSA-6802948	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6802948
Reactome	R-HSA-6802949	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6802949
Reactome	R-HSA-6802952	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6802952
Reactome	R-HSA-6802955	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6802955
Reactome	R-HSA-8875555	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8875555
RefSeq	NP_001010935	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001010935
RefSeq	NP_001278825	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001278825
RefSeq	NP_002875	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002875
RefSeq	XP_016857451	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016857451
RefSeq	XP_016857452	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016857452
RefSeq	XP_016857453	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016857453
SMR	P62834	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P62834
STRING	9606.ENSP00000348786	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000348786&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TIGRFAMs	TIGR00231	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00231
UCSC	uc001ebi	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001ebi&org=rat
UniGene	Hs.190334	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.190334
UniGene	Hs.586618	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.586618
UniProtKB	RAP1A_HUMAN	http://www.uniprot.org/uniprot/RAP1A_HUMAN
UniProtKB-AC	P62834	http://www.uniprot.org/uniprot/P62834
charge	swissprot:RAP1A_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:RAP1A_HUMAN
eggNOG	COG1100	http://eggnogapi.embl.de/nog_data/html/tree/COG1100
eggNOG	KOG0395	http://eggnogapi.embl.de/nog_data/html/tree/KOG0395
epestfind	swissprot:RAP1A_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:RAP1A_HUMAN
garnier	swissprot:RAP1A_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:RAP1A_HUMAN
helixturnhelix	swissprot:RAP1A_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:RAP1A_HUMAN
hmoment	swissprot:RAP1A_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:RAP1A_HUMAN
iep	swissprot:RAP1A_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:RAP1A_HUMAN
inforesidue	swissprot:RAP1A_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:RAP1A_HUMAN
neXtProt	NX_P62834	http://www.nextprot.org/db/entry/NX_P62834
octanol	swissprot:RAP1A_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:RAP1A_HUMAN
pepcoil	swissprot:RAP1A_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:RAP1A_HUMAN
pepdigest	swissprot:RAP1A_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:RAP1A_HUMAN
pepinfo	swissprot:RAP1A_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:RAP1A_HUMAN
pepnet	swissprot:RAP1A_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:RAP1A_HUMAN
pepstats	swissprot:RAP1A_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:RAP1A_HUMAN
pepwheel	swissprot:RAP1A_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:RAP1A_HUMAN
pepwindow	swissprot:RAP1A_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:RAP1A_HUMAN
sigcleave	swissprot:RAP1A_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:RAP1A_HUMAN
## Database	ID	URL or Descriptions
# AltName	COX5B_HUMAN	Cytochrome c oxidase polypeptide Vb
# BioGrid	107722	39
# CDD	cd00924	Cyt_c_Oxidase_Vb
# ChiTaRS	COX5B	human
# DrugBank	DB02659	Cholic Acid
# Ensembl	ENST00000258424	ENSP00000258424; ENSG00000135940
# FUNCTION	COX5B_HUMAN	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. 
# GO_component	GO:0005739	mitochondrion; IDA:HPA.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0005751	mitochondrial respiratory chain complex IV; IBA:GO_Central.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0004129	cytochrome-c oxidase activity; TAS:ProtInc.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen; IBA:GO_Central.
# GO_process	GO:0007585	respiratory gaseous exchange; TAS:ProtInc.
# GO_process	GO:0042776	mitochondrial ATP synthesis coupled proton transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.11.10	-; 1.
# Genevisible	P10606	HS
# HGNC	HGNC:2269	COX5B
# INTERACTION	COX5B_HUMAN	O14503 BHLHE40; NbExp=3; IntAct=EBI-1053725, EBI-711810; Q8IYA8 CCDC36; NbExp=4; IntAct=EBI-1053725, EBI-8638439; Q01850 CDR2; NbExp=5; IntAct=EBI-1053725, EBI-1181367; P19012 KRT15; NbExp=3; IntAct=EBI-1053725, EBI-739566; Q15323 KRT31; NbExp=3; IntAct=EBI-1053725, EBI-948001; Q8ND90 PNMA1; NbExp=3; IntAct=EBI-1053725, EBI-302345; Q9UBB9 TFIP11; NbExp=3; IntAct=EBI-1053725, EBI-1105213; Q13077 TRAF1; NbExp=3; IntAct=EBI-1053725, EBI-359224; P36406 TRIM23; NbExp=4; IntAct=EBI-1053725, EBI-740098; 
# IntAct	P10606	28
# InterPro	IPR002124	Cyt_c_oxidase_su5b
# InterPro	IPR020893	Cyt_c_oxidase_su5b_Zn_BS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	123866	gene
# Organism	COX5B_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10122	PTHR10122
# PIR	JT0324	OTHU5B
# PROSITE	PS00848	COX5B_1
# PROSITE	PS51359	COX5B_2
# Pfam	PF01215	COX5B
# ProDom	PD007270	Cyt_c_oxidase_su5b
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-5628897	TP53 Regulates Metabolic Genes
# Reactome	R-HSA-611105	Respiratory electron transport
# RecName	COX5B_HUMAN	Cytochrome c oxidase subunit 5B, mitochondrial
# RefSeq	NP_001853	NM_001862.2
# SIMILARITY	Belongs to the cytochrome c oxidase subunit 5B family. {ECO	0000305}.
# SUBCELLULAR LOCATION	COX5B_HUMAN	Mitochondrion inner membrane. 
# TCDB	3.D.4.11	the proton-translocating cytochrome oxidase (cox) superfamily
# UCSC	uc002sya	human
# eggNOG	ENOG4111XEM	LUCA
# eggNOG	KOG3352	Eukaryota
BLAST	swissprot:COX5B_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:COX5B_HUMAN
BioCyc	ZFISH:HS06090-MONOMER	http://biocyc.org/getid?id=ZFISH:HS06090-MONOMER
COXPRESdb	1329	http://coxpresdb.jp/data/gene/1329.shtml
CleanEx	HS_COX5B	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_COX5B
DOI	10.1002/elps.11501401181	http://dx.doi.org/10.1002/elps.11501401181
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/abbi.1996.0376	http://dx.doi.org/10.1006/abbi.1996.0376
DOI	10.1016/0378-1119(88)90411-8	http://dx.doi.org/10.1016/0378-1119(88)90411-8
DOI	10.1016/0888-7543(91)90476-U	http://dx.doi.org/10.1016/0888-7543(91)90476-U
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DrugBank	DB02659	http://www.drugbank.ca/drugs/DB02659
EMBL	AC017099	http://www.ebi.ac.uk/ena/data/view/AC017099
EMBL	BC006229	http://www.ebi.ac.uk/ena/data/view/BC006229
EMBL	BT006742	http://www.ebi.ac.uk/ena/data/view/BT006742
EMBL	M19961	http://www.ebi.ac.uk/ena/data/view/M19961
EMBL	M59250	http://www.ebi.ac.uk/ena/data/view/M59250
EMBL	U41284	http://www.ebi.ac.uk/ena/data/view/U41284
Ensembl	ENST00000258424	http://www.ensembl.org/id/ENST00000258424
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005751	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005751
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0004129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004129
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006123	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006123
GO_process	GO:0007585	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007585
GO_process	GO:0042776	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042776
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.11.10	http://www.cathdb.info/version/latest/superfamily/2.60.11.10
GeneCards	COX5B	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=COX5B
GeneID	1329	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1329
GeneTree	ENSGT00390000011010	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000011010
HGNC	HGNC:2269	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2269
HOGENOM	HOG000184129	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000184129&db=HOGENOM6
HOVERGEN	HBG051089	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051089&db=HOVERGEN
HPA	HPA034517	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA034517
InParanoid	P10606	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P10606
IntAct	P10606	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P10606*
InterPro	IPR002124	http://www.ebi.ac.uk/interpro/entry/IPR002124
InterPro	IPR020893	http://www.ebi.ac.uk/interpro/entry/IPR020893
Jabion	1329	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1329
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Gene	hsa:1329	http://www.genome.jp/dbget-bin/www_bget?hsa:1329
KEGG_Orthology	KO:K02265	http://www.genome.jp/dbget-bin/www_bget?KO:K02265
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	123866	http://www.ncbi.nlm.nih.gov/omim/123866
MINT	MINT-3007350	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3007350
OMA	PYNMLPP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PYNMLPP
OrthoDB	EOG091G0S9L	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0S9L
PANTHER	PTHR10122	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10122
PROSITE	PS00848	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00848
PROSITE	PS51359	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51359
PSORT	swissprot:COX5B_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:COX5B_HUMAN
PSORT-B	swissprot:COX5B_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:COX5B_HUMAN
PSORT2	swissprot:COX5B_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:COX5B_HUMAN
Pfam	PF01215	http://pfam.xfam.org/family/PF01215
PharmGKB	PA26786	http://www.pharmgkb.org/do/serve?objId=PA26786&objCls=Gene
Phobius	swissprot:COX5B_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:COX5B_HUMAN
PhylomeDB	P10606	http://phylomedb.org/?seqid=P10606
ProteinModelPortal	P10606	http://www.proteinmodelportal.org/query/uniprot/P10606
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	1646156	http://www.ncbi.nlm.nih.gov/pubmed/1646156
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	2840351	http://www.ncbi.nlm.nih.gov/pubmed/2840351
PubMed	8313870	http://www.ncbi.nlm.nih.gov/pubmed/8313870
PubMed	8806766	http://www.ncbi.nlm.nih.gov/pubmed/8806766
Reactome	R-HSA-5628897	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5628897
Reactome	R-HSA-611105	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-611105
RefSeq	NP_001853	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001853
SMR	P10606	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P10606
STRING	9606.ENSP00000258424	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000258424&targetmode=cogs
SWISS-2DPAGE	P10606	http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P10606
TCDB	3.D.4.11	http://www.tcdb.org/search/result.php?tc=3.D.4.11
UCSC	uc002sya	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002sya&org=rat
UniGene	Hs.1342	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.1342
UniProtKB	COX5B_HUMAN	http://www.uniprot.org/uniprot/COX5B_HUMAN
UniProtKB-AC	P10606	http://www.uniprot.org/uniprot/P10606
charge	swissprot:COX5B_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:COX5B_HUMAN
eggNOG	ENOG4111XEM	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111XEM
eggNOG	KOG3352	http://eggnogapi.embl.de/nog_data/html/tree/KOG3352
epestfind	swissprot:COX5B_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:COX5B_HUMAN
garnier	swissprot:COX5B_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:COX5B_HUMAN
helixturnhelix	swissprot:COX5B_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:COX5B_HUMAN
hmoment	swissprot:COX5B_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:COX5B_HUMAN
iep	swissprot:COX5B_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:COX5B_HUMAN
inforesidue	swissprot:COX5B_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:COX5B_HUMAN
neXtProt	NX_P10606	http://www.nextprot.org/db/entry/NX_P10606
octanol	swissprot:COX5B_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:COX5B_HUMAN
pepcoil	swissprot:COX5B_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:COX5B_HUMAN
pepdigest	swissprot:COX5B_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:COX5B_HUMAN
pepinfo	swissprot:COX5B_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:COX5B_HUMAN
pepnet	swissprot:COX5B_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:COX5B_HUMAN
pepstats	swissprot:COX5B_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:COX5B_HUMAN
pepwheel	swissprot:COX5B_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:COX5B_HUMAN
pepwindow	swissprot:COX5B_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:COX5B_HUMAN
sigcleave	swissprot:COX5B_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:COX5B_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CNGA4_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8IV77-1; Sequence=Displayed; Name=2; IsoId=Q8IV77-2; Sequence=VSP_039919, VSP_039920, VSP_039921; Note=No experimental confirmation available.; 
# AltName	CNGA4_HUMAN	Cyclic nucleotide-gated channel alpha-4
# CCDS	CCDS31408	-. [Q8IV77-1]
# DOMAIN	CNGA4_HUMAN	The C-terminal coiled-coil domain mediates trimerization of CNGA subunits. {ECO 0000250}. 
# ENZYME REGULATION	Calcium-calmodulin exerts its inhibitory effect in cAMP sensitivity by binding to IQ-like motif of CNGA4 and preferably binds to the channel in the closed state. Inhibition by PIP3 of the CNG channel probably occurs via CGNA2 binding. {ECO:0000269|PubMed	17032767}. 
# Ensembl	ENST00000379936	ENSP00000369268; ENSG00000132259. [Q8IV77-1]
# ExpressionAtlas	Q8IV77	baseline and differential
# FUNCTION	CNGA4_HUMAN	Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity). {ECO 0000250}. 
# GO_component	GO:0000139	Golgi membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0030660	Golgi-associated vesicle membrane; TAS:Reactome.
# GO_component	GO:0060170	ciliary membrane; TAS:Reactome.
# GO_function	GO:0005222	intracellular cAMP activated cation channel activity; IBA:GO_Central.
# GO_function	GO:0005223	intracellular cGMP activated cation channel activity; IBA:GO_Central.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IBA:GO_Central.
# GO_function	GO:0030552	cAMP binding; IEA:UniProtKB-KW.
# GO_function	GO:0030553	cGMP binding; IBA:GO_Central.
# GO_process	GO:0007608	sensory perception of smell; IEA:UniProtKB-KW.
# GO_process	GO:0042391	regulation of membrane potential; IBA:GO_Central.
# GO_process	GO:0050896	response to stimulus; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# Gene3D	2.60.120.10	-; 1.
# Genevisible	Q8IV77	HS
# HGNC	HGNC:2152	CNGA4
# InterPro	IPR000595	cNMP-bd_dom
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR014710	RmlC-like_jellyroll
# InterPro	IPR018488	cNMP-bd_CS
# InterPro	IPR018490	cNMP-bd-like
# InterPro	IPR032406	CLZ_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04740	Olfactory transduction
# MIM	609472	gene
# Organism	CNGA4_HUMAN	Homo sapiens (Human)
# PROSITE	PS00888	CNMP_BINDING_1
# PROSITE	PS00889	CNMP_BINDING_2
# PROSITE	PS50042	CNMP_BINDING_3
# Pfam	PF00027	cNMP_binding
# Pfam	PF00520	Ion_trans
# Pfam	PF16526	CLZ
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-5620916	VxPx cargo-targeting to cilium
# RecName	CNGA4_HUMAN	Cyclic nucleotide-gated cation channel alpha-4
# RefSeq	NP_001032406	NM_001037329.3. [Q8IV77-1]
# SEQUENCE CAUTION	Sequence=AAH40277.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AK122736; Type=Frameshift; Positions=154; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA4 subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 cyclic nucleotide-binding domain. {ECO:0000255|PROSITE-ProRule	PRU00060}. 
# SMART	SM00100	cNMP
# SUBCELLULAR LOCATION	CNGA4_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUBUNIT	Heterotetramer composed of two subunits of CNGA2, one of CNGA4 and one of CNGB1b. The complex forms the cyclic nucleotide- gated (CNG) channel of olfactory sensory neurons. {ECO:0000269|PubMed	15195096}. 
# SUPFAM	SSF51206	SSF51206
# UCSC	uc001mco	human. [Q8IV77-1]
# eggNOG	ENOG410YWWI	LUCA
# eggNOG	KOG0500	Eukaryota
BLAST	swissprot:CNGA4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CNGA4_HUMAN
COXPRESdb	1262	http://coxpresdb.jp/data/gene/1262.shtml
CleanEx	HS_CNGA4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CNGA4
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/nn1266	http://dx.doi.org/10.1038/nn1266
DOI	10.1073/pnas.0603344103	http://dx.doi.org/10.1073/pnas.0603344103
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC022762	http://www.ebi.ac.uk/ena/data/view/AC022762
EMBL	AK122736	http://www.ebi.ac.uk/ena/data/view/AK122736
EMBL	BC040277	http://www.ebi.ac.uk/ena/data/view/BC040277
EMBL	BC106935	http://www.ebi.ac.uk/ena/data/view/BC106935
EMBL	BC106936	http://www.ebi.ac.uk/ena/data/view/BC106936
Ensembl	ENST00000379936	http://www.ensembl.org/id/ENST00000379936
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0030660	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030660
GO_component	GO:0060170	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060170
GO_function	GO:0005222	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005222
GO_function	GO:0005223	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005223
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0030552	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030552
GO_function	GO:0030553	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030553
GO_process	GO:0007608	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007608
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0050896	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050896
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
Gene3D	2.60.120.10	http://www.cathdb.info/version/latest/superfamily/2.60.120.10
GeneCards	CNGA4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CNGA4
GeneID	1262	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1262
GeneTree	ENSGT00760000118772	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118772
H-InvDB	HIX0026152	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0026152
HGNC	HGNC:2152	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2152
HOGENOM	HOG000007898	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007898&db=HOGENOM6
HOVERGEN	HBG000281	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000281&db=HOVERGEN
InParanoid	Q8IV77	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8IV77
InterPro	IPR000595	http://www.ebi.ac.uk/interpro/entry/IPR000595
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR014710	http://www.ebi.ac.uk/interpro/entry/IPR014710
InterPro	IPR018488	http://www.ebi.ac.uk/interpro/entry/IPR018488
InterPro	IPR018490	http://www.ebi.ac.uk/interpro/entry/IPR018490
InterPro	IPR032406	http://www.ebi.ac.uk/interpro/entry/IPR032406
Jabion	1262	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1262
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:1262	http://www.genome.jp/dbget-bin/www_bget?hsa:1262
KEGG_Orthology	KO:K04951	http://www.genome.jp/dbget-bin/www_bget?KO:K04951
KEGG_Pathway	ko04740	http://www.genome.jp/kegg-bin/show_pathway?ko04740
MIM	609472	http://www.ncbi.nlm.nih.gov/omim/609472
OMA	VRTWSFL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VRTWSFL
OrthoDB	EOG091G03EW	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G03EW
PROSITE	PS00888	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00888
PROSITE	PS00889	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00889
PROSITE	PS50042	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50042
PSORT	swissprot:CNGA4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CNGA4_HUMAN
PSORT-B	swissprot:CNGA4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CNGA4_HUMAN
PSORT2	swissprot:CNGA4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CNGA4_HUMAN
Pfam	PF00027	http://pfam.xfam.org/family/PF00027
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF16526	http://pfam.xfam.org/family/PF16526
Phobius	swissprot:CNGA4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CNGA4_HUMAN
PhylomeDB	Q8IV77	http://phylomedb.org/?seqid=Q8IV77
ProteinModelPortal	Q8IV77	http://www.proteinmodelportal.org/query/uniprot/Q8IV77
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15195096	http://www.ncbi.nlm.nih.gov/pubmed/15195096
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	17032767	http://www.ncbi.nlm.nih.gov/pubmed/17032767
Reactome	R-HSA-5620916	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5620916
RefSeq	NP_001032406	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001032406
SMART	SM00100	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00100
SMR	Q8IV77	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8IV77
STRING	9606.ENSP00000369268	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000369268&targetmode=cogs
SUPFAM	SSF51206	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51206
UCSC	uc001mco	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001mco&org=rat
UniGene	Hs.434618	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.434618
UniProtKB	CNGA4_HUMAN	http://www.uniprot.org/uniprot/CNGA4_HUMAN
UniProtKB-AC	Q8IV77	http://www.uniprot.org/uniprot/Q8IV77
charge	swissprot:CNGA4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CNGA4_HUMAN
eggNOG	ENOG410YWWI	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YWWI
eggNOG	KOG0500	http://eggnogapi.embl.de/nog_data/html/tree/KOG0500
epestfind	swissprot:CNGA4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CNGA4_HUMAN
garnier	swissprot:CNGA4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CNGA4_HUMAN
helixturnhelix	swissprot:CNGA4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CNGA4_HUMAN
hmoment	swissprot:CNGA4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CNGA4_HUMAN
iep	swissprot:CNGA4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CNGA4_HUMAN
inforesidue	swissprot:CNGA4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CNGA4_HUMAN
neXtProt	NX_Q8IV77	http://www.nextprot.org/db/entry/NX_Q8IV77
octanol	swissprot:CNGA4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CNGA4_HUMAN
pepcoil	swissprot:CNGA4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CNGA4_HUMAN
pepdigest	swissprot:CNGA4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CNGA4_HUMAN
pepinfo	swissprot:CNGA4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CNGA4_HUMAN
pepnet	swissprot:CNGA4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CNGA4_HUMAN
pepstats	swissprot:CNGA4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CNGA4_HUMAN
pepwheel	swissprot:CNGA4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CNGA4_HUMAN
pepwindow	swissprot:CNGA4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CNGA4_HUMAN
sigcleave	swissprot:CNGA4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CNGA4_HUMAN
## Database	ID	URL or Descriptions
# AltName	CTR3_HUMAN	Cationic amino acid transporter y+
# AltName	CTR3_HUMAN	Solute carrier family 7 member 3
# BioGrid	124329	14
# DrugBank	DB00123	L-Lysine
# DrugBank	DB00125	L-Arginine
# DrugBank	DB00129	L-Ornithine
# Ensembl	ENST00000298085	ENSP00000298085; ENSG00000165349
# Ensembl	ENST00000374299	ENSP00000363417; ENSG00000165349
# FUNCTION	CTR3_HUMAN	Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. {ECO 0000269|PubMed 11591158}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0000064	L-ornithine transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015181	arginine transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015189	L-lysine transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015297	antiporter activity; IBA:GO_Central.
# GO_process	GO:0006865	amino acid transport; TAS:Reactome.
# GO_process	GO:0015809	arginine transport; IEA:Ensembl.
# GO_process	GO:1903352	L-ornithine transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q8WY07	HS
# HGNC	HGNC:11061	SLC7A3
# InterPro	IPR002293	AA/rel_permease1
# InterPro	IPR004755	Cat_AA_permease
# InterPro	IPR015606	CAT3
# InterPro	IPR029485	CAT_C
# KEGG_Brite	ko02001	Solute carrier family
# MIM	300443	gene
# Organism	CTR3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11785	PTHR11785; 3
# PANTHER	PTHR11785:SF209	PTHR11785:SF209; 3
# PTM	CTR3_HUMAN	N-glycosylated. {ECO 0000269|PubMed 11591158}. 
# Pfam	PF13520	AA_permease_2
# Pfam	PF13906	AA_permease_C
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-352230	Amino acid transport across the plasma membrane
# RecName	CTR3_HUMAN	Cationic amino acid transporter 3
# RefSeq	NP_001041629	NM_001048164.2
# RefSeq	NP_116192	NM_032803.5
# RefSeq	XP_016885401	XM_017029912.1
# SEQUENCE CAUTION	Sequence=BAB55118.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	CTR3_HUMAN	Cell membrane; Multi-pass membrane protein. 
# TCDB	2.A.3.3.10	the amino acid-polyamine-organocation (apc) family
# TIGRFAMs	TIGR00906	2A0303
# TISSUE SPECIFICITY	Highly expressed in thymus, uterus and testis. Detected at lower levels in brain, mammary gland, prostate, salivary gland and fetal spleen. In brain, highest expression in thalamus, hippocampus and amygdala. {ECO:0000269|PubMed	11591158}. 
# UCSC	uc004dyn	human
# eggNOG	COG0531	LUCA
# eggNOG	KOG1286	Eukaryota
BLAST	swissprot:CTR3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CTR3_HUMAN
BioCyc	ZFISH:ENSG00000165349-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000165349-MONOMER
COXPRESdb	84889	http://coxpresdb.jp/data/gene/84889.shtml
CleanEx	HS_SLC7A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC7A3
DOI	10.1021/bi011345c	http://dx.doi.org/10.1021/bi011345c
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1038/nature09639	http://dx.doi.org/10.1038/nature09639
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DrugBank	DB00123	http://www.drugbank.ca/drugs/DB00123
DrugBank	DB00125	http://www.drugbank.ca/drugs/DB00125
DrugBank	DB00129	http://www.drugbank.ca/drugs/DB00129
EMBL	AF320612	http://www.ebi.ac.uk/ena/data/view/AF320612
EMBL	AK027447	http://www.ebi.ac.uk/ena/data/view/AK027447
EMBL	AK074865	http://www.ebi.ac.uk/ena/data/view/AK074865
EMBL	AK075014	http://www.ebi.ac.uk/ena/data/view/AK075014
EMBL	AL627071	http://www.ebi.ac.uk/ena/data/view/AL627071
EMBL	BC033816	http://www.ebi.ac.uk/ena/data/view/BC033816
EMBL	CH471132	http://www.ebi.ac.uk/ena/data/view/CH471132
EMBL	CH471132	http://www.ebi.ac.uk/ena/data/view/CH471132
Ensembl	ENST00000298085	http://www.ensembl.org/id/ENST00000298085
Ensembl	ENST00000374299	http://www.ensembl.org/id/ENST00000374299
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0000064	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000064
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_function	GO:0015181	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015181
GO_function	GO:0015189	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015189
GO_function	GO:0015297	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GO_process	GO:0015809	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015809
GO_process	GO:1903352	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903352
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC7A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC7A3
GeneID	84889	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84889
GeneTree	ENSGT00760000119151	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119151
HGNC	HGNC:11061	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11061
HOGENOM	HOG000250623	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000250623&db=HOGENOM6
HOVERGEN	HBG000280	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000280&db=HOVERGEN
HPA	HPA003629	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA003629
InParanoid	Q8WY07	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8WY07
InterPro	IPR002293	http://www.ebi.ac.uk/interpro/entry/IPR002293
InterPro	IPR004755	http://www.ebi.ac.uk/interpro/entry/IPR004755
InterPro	IPR015606	http://www.ebi.ac.uk/interpro/entry/IPR015606
InterPro	IPR029485	http://www.ebi.ac.uk/interpro/entry/IPR029485
Jabion	84889	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=84889
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:84889	http://www.genome.jp/dbget-bin/www_bget?hsa:84889
KEGG_Orthology	KO:K13865	http://www.genome.jp/dbget-bin/www_bget?KO:K13865
MIM	300443	http://www.ncbi.nlm.nih.gov/omim/300443
OMA	YTGWAPA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YTGWAPA
OrthoDB	EOG091G05NM	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05NM
PANTHER	PTHR11785	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785
PANTHER	PTHR11785:SF209	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785:SF209
PSORT	swissprot:CTR3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CTR3_HUMAN
PSORT-B	swissprot:CTR3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CTR3_HUMAN
PSORT2	swissprot:CTR3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CTR3_HUMAN
Pfam	PF13520	http://pfam.xfam.org/family/PF13520
Pfam	PF13906	http://pfam.xfam.org/family/PF13906
PharmGKB	PA35921	http://www.pharmgkb.org/do/serve?objId=PA35921&objCls=Gene
Phobius	swissprot:CTR3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CTR3_HUMAN
PhylomeDB	Q8WY07	http://phylomedb.org/?seqid=Q8WY07
ProteinModelPortal	Q8WY07	http://www.proteinmodelportal.org/query/uniprot/Q8WY07
PubMed	11591158	http://www.ncbi.nlm.nih.gov/pubmed/11591158
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	21248752	http://www.ncbi.nlm.nih.gov/pubmed/21248752
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
Reactome	R-HSA-352230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-352230
RefSeq	NP_001041629	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001041629
RefSeq	NP_116192	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_116192
RefSeq	XP_016885401	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016885401
STRING	9606.ENSP00000298085	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000298085&targetmode=cogs
TCDB	2.A.3.3.10	http://www.tcdb.org/search/result.php?tc=2.A.3.3.10
TIGRFAMs	TIGR00906	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00906
UCSC	uc004dyn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004dyn&org=rat
UniGene	Hs.175220	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.175220
UniProtKB	CTR3_HUMAN	http://www.uniprot.org/uniprot/CTR3_HUMAN
UniProtKB-AC	Q8WY07	http://www.uniprot.org/uniprot/Q8WY07
charge	swissprot:CTR3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CTR3_HUMAN
eggNOG	COG0531	http://eggnogapi.embl.de/nog_data/html/tree/COG0531
eggNOG	KOG1286	http://eggnogapi.embl.de/nog_data/html/tree/KOG1286
epestfind	swissprot:CTR3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CTR3_HUMAN
garnier	swissprot:CTR3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CTR3_HUMAN
helixturnhelix	swissprot:CTR3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CTR3_HUMAN
hmoment	swissprot:CTR3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CTR3_HUMAN
iep	swissprot:CTR3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CTR3_HUMAN
inforesidue	swissprot:CTR3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CTR3_HUMAN
neXtProt	NX_Q8WY07	http://www.nextprot.org/db/entry/NX_Q8WY07
octanol	swissprot:CTR3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CTR3_HUMAN
pepcoil	swissprot:CTR3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CTR3_HUMAN
pepdigest	swissprot:CTR3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CTR3_HUMAN
pepinfo	swissprot:CTR3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CTR3_HUMAN
pepnet	swissprot:CTR3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CTR3_HUMAN
pepstats	swissprot:CTR3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CTR3_HUMAN
pepwheel	swissprot:CTR3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CTR3_HUMAN
pepwindow	swissprot:CTR3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CTR3_HUMAN
sigcleave	swissprot:CTR3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CTR3_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	115338	3
# DISEASE	HCN4_HUMAN	Brugada syndrome 8 (BRGDA8) [MIM 613123]  A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset. {ECO 0000269|PubMed 19165230}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	HCN4_HUMAN	Sick sinus syndrome 2 (SSS2) [MIM 163800]  The term 'sick sinus syndrome' encompasses a variety of conditions caused by sinus node dysfunction. The most common clinical manifestations are syncope, presyncope, dizziness, and fatigue. Electrocardiogram typically shows sinus bradycardia, sinus arrest, and/or sinoatrial block. Episodes of atrial tachycardias coexisting with sinus bradycardia ('tachycardia-bradycardia syndrome') are also common in this disorder. SSS occurs most often in the elderly associated with underlying heart disease or previous cardiac surgery, but can also occur in the fetus, infant, or child without heart disease or other contributing factors. SSS2 onset is in utero or at birth. {ECO 0000269|PubMed 15123648, ECO 0000269|PubMed 16407510, ECO 0000269|PubMed 20662977}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	HCN4_HUMAN	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. 
# ENZYME REGULATION	HCN4_HUMAN	Activated by cAMP. cAMP binding causes a conformation change that leads to the assembly of an active tetramer and channel opening. {ECO 0000269|PubMed 16407510, ECO 0000269|PubMed 20829353, ECO 0000269|PubMed 22006928}. 
# Ensembl	ENST00000261917	ENSP00000261917; ENSG00000138622
# FUNCTION	HCN4_HUMAN	Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli. {ECO 0000269|PubMed 10228147, ECO 0000269|PubMed 10430953, ECO 0000269|PubMed 16407510, ECO 0000269|PubMed 19165230, ECO 0000269|PubMed 20829353}. 
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0031226	intrinsic component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IDA:BHF-UCL.
# GO_function	GO:0005222	intracellular cAMP activated cation channel activity; IDA:UniProtKB.
# GO_function	GO:0005248	voltage-gated sodium channel activity; IMP:UniProtKB.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IDA:UniProtKB.
# GO_function	GO:0030552	cAMP binding; IEA:UniProtKB-KW.
# GO_process	GO:0002027	regulation of heart rate; IMP:UniProtKB.
# GO_process	GO:0003254	regulation of membrane depolarization; IDA:BHF-UCL.
# GO_process	GO:0006812	cation transport; IDA:BHF-UCL.
# GO_process	GO:0006936	muscle contraction; TAS:ProtInc.
# GO_process	GO:0008015	blood circulation; NAS:ProtInc.
# GO_process	GO:0035725	sodium ion transmembrane transport; IMP:UniProtKB.
# GO_process	GO:0042391	regulation of membrane potential; IMP:UniProtKB.
# GO_process	GO:0055117	regulation of cardiac muscle contraction; IMP:BHF-UCL.
# GO_process	GO:0071320	cellular response to cAMP; IDA:UniProtKB.
# GO_process	GO:0071321	cellular response to cGMP; IDA:UniProtKB.
# GO_process	GO:0071805	potassium ion transmembrane transport; IDA:UniProtKB.
# GO_process	GO:0086015	SA node cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086091	regulation of heart rate by cardiac conduction; IMP:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0003013	circulatory system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.120.10	-; 1.
# Genevisible	Q9Y3Q4	HS
# HGNC	HGNC:16882	HCN4
# INTERACTION	HCN4_HUMAN	Self; NbExp=2; IntAct=EBI-1753521, EBI-1753521; 
# IntAct	Q9Y3Q4	2
# InterPro	IPR000595	cNMP-bd_dom
# InterPro	IPR003938	K_chnl_volt-dep_EAG/ELK/ERG
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR013621	Ion_trans_N
# InterPro	IPR014710	RmlC-like_jellyroll
# InterPro	IPR018488	cNMP-bd_CS
# InterPro	IPR018490	cNMP-bd-like
# InterPro	IPR030173	HCN4
# KEGG_Brite	ko04040	Ion channels
# KEGG_Disease	H00728	[Cardiovascular disease] Brugada syndrome (BRS)
# KEGG_Disease	H00729	[Cardiovascular disease] Sinus node dysfunction
# MIM	163800	phenotype
# MIM	605206	gene
# MIM	613123	phenotype
# MISCELLANEOUS	HCN4_HUMAN	Inhibited by extracellular cesium ions. 
# Organism	HCN4_HUMAN	Homo sapiens (Human)
# Orphanet	130	Brugada syndrome
# Orphanet	166282	Familial sick sinus syndrome
# PANTHER	PTHR10217:SF375	PTHR10217:SF375; 3
# PDB	2MNG	NMR; -; A=579-707
# PDB	3OTF	X-ray; 2.40 A; A=521-739
# PDB	3U11	X-ray; 2.50 A; A/B=521-723
# PDB	4HBN	X-ray; 2.60 A; A=521-724
# PDB	4KL1	X-ray; 2.70 A; A/B/C/D=521-713
# PDB	4NVP	X-ray; 2.50 A; A=521-723
# PRINTS	PR01463	EAGCHANLFMLY
# PROSITE	PS00888	CNMP_BINDING_1
# PROSITE	PS50042	CNMP_BINDING_3
# Pfam	PF00027	cNMP_binding
# Pfam	PF00520	Ion_trans
# Pfam	PF08412	Ion_trans_N
# Proteomes	UP000005640	Chromosome 15
# Reactome	R-HSA-1296061	HCN channels
# RecName	HCN4_HUMAN	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
# RefSeq	NP_005468	NM_005477.2
# SIMILARITY	Belongs to the potassium channel HCN family. {ECO	0000305}. 
# SIMILARITY	Contains 1 cyclic nucleotide-binding domain. {ECO:0000255|PROSITE-ProRule	PRU00060}.
# SMART	SM00100	cNMP
# SUBCELLULAR LOCATION	HCN4_HUMAN	Cell membrane {ECO 0000269|PubMed 10228147, ECO 0000269|PubMed 10430953, ECO 0000269|PubMed 16407510}; Multi- pass membrane protein {ECO 0000269|PubMed 10228147, ECO 0000269|PubMed 10430953, ECO 0000269|PubMed 16407510}. 
# SUBUNIT	HCN4_HUMAN	Homotetramer. The potassium channel is composed of a homo- or heterotetrameric complex of pore-forming subunits. {ECO 0000269|PubMed 20829353, ECO 0000269|PubMed 22006928}. 
# SUPFAM	SSF51206	SSF51206
# TCDB	1.A.1.5.10	the voltage-gated ion channel (vic) superfamily
# TCDB	1.A.1.5.11	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	HCN4_HUMAN	Highly expressed in thalamus, testis and in heart, both in ventricle and atrium. Detected at much lower levels in amygdala, substantia nigra, cerebellum and hippocampus. {ECO 0000269|PubMed 10228147, ECO 0000269|PubMed 10430953}. 
# UCSC	uc002avp	human
# eggNOG	ENOG410XPSE	LUCA
# eggNOG	KOG0498	Eukaryota
BLAST	swissprot:HCN4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:HCN4_HUMAN
BioCyc	ZFISH:ENSG00000138622-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000138622-MONOMER
COXPRESdb	10021	http://coxpresdb.jp/data/gene/10021.shtml
CleanEx	HS_HCN4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_HCN4
DIP	DIP-52325N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-52325N
DOI	10.1016/j.str.2012.09.017	http://dx.doi.org/10.1016/j.str.2012.09.017
DOI	10.1038/jhg.2008.16	http://dx.doi.org/10.1038/jhg.2008.16
DOI	10.1056/NEJMoa052475	http://dx.doi.org/10.1056/NEJMoa052475
DOI	10.1073/pnas.96.16.9391	http://dx.doi.org/10.1073/pnas.96.16.9391
DOI	10.1074/jbc.M110.152033	http://dx.doi.org/10.1074/jbc.M110.152033
DOI	10.1074/jbc.M111.297606	http://dx.doi.org/10.1074/jbc.M111.297606
DOI	10.1074/jbc.M311953200	http://dx.doi.org/10.1074/jbc.M311953200
DOI	10.1093/emboj/18.9.2323	http://dx.doi.org/10.1093/emboj/18.9.2323
DOI	10.1111/j.1540-8167.2010.01844.x	http://dx.doi.org/10.1111/j.1540-8167.2010.01844.x
EMBL	AJ132429	http://www.ebi.ac.uk/ena/data/view/AJ132429
EMBL	AJ238850	http://www.ebi.ac.uk/ena/data/view/AJ238850
Ensembl	ENST00000261917	http://www.ensembl.org/id/ENST00000261917
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0031226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031226
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_function	GO:0005222	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005222
GO_function	GO:0005248	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005248
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0030552	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030552
GO_process	GO:0002027	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002027
GO_process	GO:0003254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003254
GO_process	GO:0006812	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006812
GO_process	GO:0006936	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006936
GO_process	GO:0008015	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008015
GO_process	GO:0035725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035725
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0055117	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055117
GO_process	GO:0071320	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071320
GO_process	GO:0071321	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071321
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GO_process	GO:0086015	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086015
GO_process	GO:0086091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086091
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0003013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003013
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.120.10	http://www.cathdb.info/version/latest/superfamily/2.60.120.10
GeneCards	HCN4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=HCN4
GeneID	10021	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10021
GeneTree	ENSGT00760000118772	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118772
HGNC	HGNC:16882	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16882
HOGENOM	HOG000230717	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230717&db=HOGENOM6
HOVERGEN	HBG039490	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG039490&db=HOVERGEN
HPA	CAB026135	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB026135
InParanoid	Q9Y3Q4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y3Q4
IntAct	Q9Y3Q4	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9Y3Q4*
InterPro	IPR000595	http://www.ebi.ac.uk/interpro/entry/IPR000595
InterPro	IPR003938	http://www.ebi.ac.uk/interpro/entry/IPR003938
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR013621	http://www.ebi.ac.uk/interpro/entry/IPR013621
InterPro	IPR014710	http://www.ebi.ac.uk/interpro/entry/IPR014710
InterPro	IPR018488	http://www.ebi.ac.uk/interpro/entry/IPR018488
InterPro	IPR018490	http://www.ebi.ac.uk/interpro/entry/IPR018490
InterPro	IPR030173	http://www.ebi.ac.uk/interpro/entry/IPR030173
Jabion	10021	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10021
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00728	http://www.genome.jp/dbget-bin/www_bget?H00728
KEGG_Disease	H00729	http://www.genome.jp/dbget-bin/www_bget?H00729
KEGG_Gene	hsa:10021	http://www.genome.jp/dbget-bin/www_bget?hsa:10021
KEGG_Orthology	KO:K04957	http://www.genome.jp/dbget-bin/www_bget?KO:K04957
MIM	163800	http://www.ncbi.nlm.nih.gov/omim/163800
MIM	605206	http://www.ncbi.nlm.nih.gov/omim/605206
MIM	613123	http://www.ncbi.nlm.nih.gov/omim/613123
OMA	GAIPGQH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GAIPGQH
Orphanet	130	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=130
Orphanet	166282	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=166282
OrthoDB	EOG091G0JQU	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0JQU
PANTHER	PTHR10217:SF375	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10217:SF375
PDB	2MNG	http://www.ebi.ac.uk/pdbe-srv/view/entry/2MNG
PDB	3OTF	http://www.ebi.ac.uk/pdbe-srv/view/entry/3OTF
PDB	3U11	http://www.ebi.ac.uk/pdbe-srv/view/entry/3U11
PDB	4HBN	http://www.ebi.ac.uk/pdbe-srv/view/entry/4HBN
PDB	4KL1	http://www.ebi.ac.uk/pdbe-srv/view/entry/4KL1
PDB	4NVP	http://www.ebi.ac.uk/pdbe-srv/view/entry/4NVP
PDBsum	2MNG	http://www.ebi.ac.uk/pdbsum/2MNG
PDBsum	3OTF	http://www.ebi.ac.uk/pdbsum/3OTF
PDBsum	3U11	http://www.ebi.ac.uk/pdbsum/3U11
PDBsum	4HBN	http://www.ebi.ac.uk/pdbsum/4HBN
PDBsum	4KL1	http://www.ebi.ac.uk/pdbsum/4KL1
PDBsum	4NVP	http://www.ebi.ac.uk/pdbsum/4NVP
PRINTS	PR01463	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01463
PROSITE	PS00888	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00888
PROSITE	PS50042	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50042
PSORT	swissprot:HCN4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:HCN4_HUMAN
PSORT-B	swissprot:HCN4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:HCN4_HUMAN
PSORT2	swissprot:HCN4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:HCN4_HUMAN
Pfam	PF00027	http://pfam.xfam.org/family/PF00027
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF08412	http://pfam.xfam.org/family/PF08412
PharmGKB	PA394	http://www.pharmgkb.org/do/serve?objId=PA394&objCls=Gene
Phobius	swissprot:HCN4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:HCN4_HUMAN
PhylomeDB	Q9Y3Q4	http://phylomedb.org/?seqid=Q9Y3Q4
ProteinModelPortal	Q9Y3Q4	http://www.proteinmodelportal.org/query/uniprot/Q9Y3Q4
PubMed	10228147	http://www.ncbi.nlm.nih.gov/pubmed/10228147
PubMed	10430953	http://www.ncbi.nlm.nih.gov/pubmed/10430953
PubMed	15123648	http://www.ncbi.nlm.nih.gov/pubmed/15123648
PubMed	16407510	http://www.ncbi.nlm.nih.gov/pubmed/16407510
PubMed	19165230	http://www.ncbi.nlm.nih.gov/pubmed/19165230
PubMed	20662977	http://www.ncbi.nlm.nih.gov/pubmed/20662977
PubMed	20829353	http://www.ncbi.nlm.nih.gov/pubmed/20829353
PubMed	22006928	http://www.ncbi.nlm.nih.gov/pubmed/22006928
PubMed	23103389	http://www.ncbi.nlm.nih.gov/pubmed/23103389
Reactome	R-HSA-1296061	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296061
RefSeq	NP_005468	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005468
SMART	SM00100	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00100
SMR	Q9Y3Q4	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9Y3Q4
STRING	9606.ENSP00000261917	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000261917&targetmode=cogs
SUPFAM	SSF51206	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51206
TCDB	1.A.1.5.10	http://www.tcdb.org/search/result.php?tc=1.A.1.5.10
TCDB	1.A.1.5.11	http://www.tcdb.org/search/result.php?tc=1.A.1.5.11
UCSC	uc002avp	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002avp&org=rat
UniGene	Hs.86941	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.86941
UniProtKB	HCN4_HUMAN	http://www.uniprot.org/uniprot/HCN4_HUMAN
UniProtKB-AC	Q9Y3Q4	http://www.uniprot.org/uniprot/Q9Y3Q4
charge	swissprot:HCN4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:HCN4_HUMAN
eggNOG	ENOG410XPSE	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPSE
eggNOG	KOG0498	http://eggnogapi.embl.de/nog_data/html/tree/KOG0498
epestfind	swissprot:HCN4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:HCN4_HUMAN
garnier	swissprot:HCN4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:HCN4_HUMAN
helixturnhelix	swissprot:HCN4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:HCN4_HUMAN
hmoment	swissprot:HCN4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:HCN4_HUMAN
iep	swissprot:HCN4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:HCN4_HUMAN
inforesidue	swissprot:HCN4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:HCN4_HUMAN
neXtProt	NX_Q9Y3Q4	http://www.nextprot.org/db/entry/NX_Q9Y3Q4
octanol	swissprot:HCN4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:HCN4_HUMAN
pepcoil	swissprot:HCN4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:HCN4_HUMAN
pepdigest	swissprot:HCN4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:HCN4_HUMAN
pepinfo	swissprot:HCN4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:HCN4_HUMAN
pepnet	swissprot:HCN4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:HCN4_HUMAN
pepstats	swissprot:HCN4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:HCN4_HUMAN
pepwheel	swissprot:HCN4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:HCN4_HUMAN
pepwindow	swissprot:HCN4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:HCN4_HUMAN
sigcleave	swissprot:HCN4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:HCN4_HUMAN
## Database	ID	URL or Descriptions
# AltName	ATPO_HUMAN	Oligomycin sensitivity conferral protein
# BioGrid	107021	101
# Ensembl	ENST00000290299	ENSP00000290299; ENSG00000241837
# ExpressionAtlas	P48047	baseline and differential
# FUNCTION	ATPO_HUMAN	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. 
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0005753	mitochondrial proton-transporting ATP synthase complex; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0031012	extracellular matrix; IDA:BHF-UCL.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005215	transporter activity; NAS:ProtInc.
# GO_function	GO:0008144	drug binding; IDA:UniProtKB.
# GO_function	GO:0022857	transmembrane transporter activity; IC:UniProtKB.
# GO_function	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism; IEA:InterPro.
# GO_process	GO:0006754	ATP biosynthetic process; NAS:UniProtKB.
# GO_process	GO:0015992	proton transport; NAS:UniProtKB.
# GO_process	GO:0042776	mitochondrial ATP synthesis coupled proton transport; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.10.520.20	-; 1.
# Genevisible	P48047	HS
# HAMAP	MF_01416	ATP_synth_delta_bact
# HGNC	HGNC:850	ATP5O
# INTERACTION	ATPO_HUMAN	Q96JN2-2 CCDC136; NbExp=3; IntAct=EBI-355815, EBI-10171416; Q8NHQ1 CEP70; NbExp=5; IntAct=EBI-355815, EBI-739624; Q6NT76 HMBOX1; NbExp=3; IntAct=EBI-355815, EBI-2549423; A1A4E9 KRT13; NbExp=3; IntAct=EBI-355815, EBI-10171552; P19012 KRT15; NbExp=3; IntAct=EBI-355815, EBI-739566; Q8TD10 MIPOL1; NbExp=3; IntAct=EBI-355815, EBI-2548751; O14777 NDC80; NbExp=3; IntAct=EBI-355815, EBI-715849; P49902 NT5C2; NbExp=3; IntAct=EBI-355815, EBI-742084; Q8ND90 PNMA1; NbExp=4; IntAct=EBI-355815, EBI-302345; Q9UBB9 TFIP11; NbExp=3; IntAct=EBI-355815, EBI-1105213; Q15654 TRIP6; NbExp=3; IntAct=EBI-355815, EBI-742327; Q8N6Y0 USHBP1; NbExp=3; IntAct=EBI-355815, EBI-739895; O43829 ZBTB14; NbExp=3; IntAct=EBI-355815, EBI-10176632; 
# IntAct	P48047	54
# InterPro	IPR000711	ATPase_OSCP/dsu
# InterPro	IPR020781	ATPase_OSCP/d_CS
# InterPro	IPR026015	ATP_synth_OSCP/delta_N
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	600828	gene
# Organism	ATPO_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11910	PTHR11910
# PRINTS	PR00125	ATPASEDELTA
# PROSITE	PS00389	ATPASE_DELTA
# PTM	ATPO_HUMAN	Acetylation at Lys-162 decreases ATP production. Deacetylated by SIRT3. {ECO 0000269|Ref.11}. 
# Pfam	PF00213	OSCP
# Proteomes	UP000005640	Chromosome 21
# Reactome	R-HSA-163210	Formation of ATP by chemiosmotic coupling
# RecName	ATPO_HUMAN	ATP synthase subunit O, mitochondrial
# RefSeq	NP_001688	NM_001697.2
# SIMILARITY	Belongs to the ATPase delta chain family. {ECO	0000305}.
# SUBCELLULAR LOCATION	ATPO_HUMAN	Mitochondrion {ECO 0000250}. Mitochondrion inner membrane {ECO 0000250}. 
# SUBUNIT	F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits	 a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity). {ECO:0000250}. 
# SUPFAM	SSF47928	SSF47928
# TIGRFAMs	TIGR01145	ATP_synt_delta
# UCSC	uc002ytl	human
# eggNOG	COG0712	LUCA
# eggNOG	KOG1662	Eukaryota
BLAST	swissprot:ATPO_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ATPO_HUMAN
BioCyc	ZFISH:HS08368-MONOMER	http://biocyc.org/getid?id=ZFISH:HS08368-MONOMER
COG	COG0712	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0712
COXPRESdb	539	http://coxpresdb.jp/data/gene/539.shtml
CleanEx	HS_ATP5O	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP5O
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/geno.1995.1176	http://dx.doi.org/10.1006/geno.1995.1176
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nbt810	http://dx.doi.org/10.1038/nbt810
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AK222962	http://www.ebi.ac.uk/ena/data/view/AK222962
EMBL	AK311796	http://www.ebi.ac.uk/ena/data/view/AK311796
EMBL	BC021233	http://www.ebi.ac.uk/ena/data/view/BC021233
EMBL	BC022865	http://www.ebi.ac.uk/ena/data/view/BC022865
EMBL	BT019836	http://www.ebi.ac.uk/ena/data/view/BT019836
EMBL	CH471079	http://www.ebi.ac.uk/ena/data/view/CH471079
EMBL	CR456822	http://www.ebi.ac.uk/ena/data/view/CR456822
EMBL	X83218	http://www.ebi.ac.uk/ena/data/view/X83218
Ensembl	ENST00000290299	http://www.ensembl.org/id/ENST00000290299
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005753	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005753
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0031012	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031012
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0008144	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008144
GO_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GO_function	GO:0046933	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046933
GO_process	GO:0006754	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006754
GO_process	GO:0015992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992
GO_process	GO:0042776	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042776
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.10.520.20	http://www.cathdb.info/version/latest/superfamily/1.10.520.20
GeneCards	ATP5O	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP5O
GeneID	539	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=539
GeneTree	ENSGT00390000015060	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000015060
H-InvDB	HIX0158705	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0158705
HAMAP	MF_01416	http://hamap.expasy.org/unirule/MF_01416
HGNC	HGNC:850	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:850
HOGENOM	HOG000075825	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000075825&db=HOGENOM6
HOVERGEN	HBG004309	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004309&db=HOVERGEN
HPA	CAB016209	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB016209
HPA	HPA041394	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA041394
InParanoid	P48047	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P48047
IntAct	P48047	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P48047*
InterPro	IPR000711	http://www.ebi.ac.uk/interpro/entry/IPR000711
InterPro	IPR020781	http://www.ebi.ac.uk/interpro/entry/IPR020781
InterPro	IPR026015	http://www.ebi.ac.uk/interpro/entry/IPR026015
Jabion	539	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=539
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:539	http://www.genome.jp/dbget-bin/www_bget?hsa:539
KEGG_Orthology	KO:K02137	http://www.genome.jp/dbget-bin/www_bget?KO:K02137
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	600828	http://www.ncbi.nlm.nih.gov/omim/600828
MINT	MINT-5002594	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5002594
OMA	MNPHVKR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MNPHVKR
OrthoDB	EOG091G0L4M	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0L4M
PANTHER	PTHR11910	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11910
PRINTS	PR00125	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00125
PROSITE	PS00389	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00389
PSORT	swissprot:ATPO_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ATPO_HUMAN
PSORT-B	swissprot:ATPO_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ATPO_HUMAN
PSORT2	swissprot:ATPO_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ATPO_HUMAN
Pfam	PF00213	http://pfam.xfam.org/family/PF00213
PharmGKB	PA25144	http://www.pharmgkb.org/do/serve?objId=PA25144&objCls=Gene
Phobius	swissprot:ATPO_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ATPO_HUMAN
PhylomeDB	P48047	http://phylomedb.org/?seqid=P48047
ProteinModelPortal	P48047	http://www.proteinmodelportal.org/query/uniprot/P48047
PubMed	12665801	http://www.ncbi.nlm.nih.gov/pubmed/12665801
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	7490082	http://www.ncbi.nlm.nih.gov/pubmed/7490082
Reactome	R-HSA-163210	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-163210
RefSeq	NP_001688	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001688
STRING	9606.ENSP00000290299	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000290299&targetmode=cogs
STRING	COG0712	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0712&targetmode=cogs
SUPFAM	SSF47928	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47928
TIGRFAMs	TIGR01145	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01145
UCSC	uc002ytl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ytl&org=rat
UniGene	Hs.409140	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.409140
UniProtKB	ATPO_HUMAN	http://www.uniprot.org/uniprot/ATPO_HUMAN
UniProtKB-AC	P48047	http://www.uniprot.org/uniprot/P48047
charge	swissprot:ATPO_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ATPO_HUMAN
eggNOG	COG0712	http://eggnogapi.embl.de/nog_data/html/tree/COG0712
eggNOG	KOG1662	http://eggnogapi.embl.de/nog_data/html/tree/KOG1662
epestfind	swissprot:ATPO_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ATPO_HUMAN
garnier	swissprot:ATPO_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ATPO_HUMAN
helixturnhelix	swissprot:ATPO_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATPO_HUMAN
hmoment	swissprot:ATPO_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ATPO_HUMAN
iep	swissprot:ATPO_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ATPO_HUMAN
inforesidue	swissprot:ATPO_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ATPO_HUMAN
neXtProt	NX_P48047	http://www.nextprot.org/db/entry/NX_P48047
octanol	swissprot:ATPO_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ATPO_HUMAN
pepcoil	swissprot:ATPO_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ATPO_HUMAN
pepdigest	swissprot:ATPO_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ATPO_HUMAN
pepinfo	swissprot:ATPO_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ATPO_HUMAN
pepnet	swissprot:ATPO_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ATPO_HUMAN
pepstats	swissprot:ATPO_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ATPO_HUMAN
pepwheel	swissprot:ATPO_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ATPO_HUMAN
pepwindow	swissprot:ATPO_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ATPO_HUMAN
sigcleave	swissprot:ATPO_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ATPO_HUMAN
## Database	ID	URL or Descriptions
# AltName	S45A1_HUMAN	Deleted in neuroblastoma 5 protein
# AltName	S45A1_HUMAN	Solute carrier family 45 member 1
# ChiTaRS	SLC45A1	human
# Ensembl	ENST00000289877	ENSP00000289877; ENSG00000162426
# ExpressionAtlas	Q9Y2W3	baseline and differential
# FUNCTION	S45A1_HUMAN	Mediates glucose uptake along the pH gradient. {ECO 0000250}. 
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_process	GO:0008643	carbohydrate transport; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q9Y2W3	HS
# HGNC	HGNC:17939	SLC45A1
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# MIM	605763	gene
# Organism	S45A1_HUMAN	Homo sapiens (Human)
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 1
# RecName	S45A1_HUMAN	Proton-associated sugar transporter A
# SEQUENCE CAUTION	Sequence=AAD27583.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=CAH70515.2; Type=Erroneous gene model prediction; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S45A1_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.2.4.10:the glycoside-pentoside-hexuronide (gph)	cation symporter family
# TISSUE SPECIFICITY	S45A1_HUMAN	Expressed in adult heart, brain, muscle and kidney, with very strong expression in brain. Also expressed in fetal brain, kidney and lung. 
# UCSC	uc001apb	human
# eggNOG	ENOG410Y28T	LUCA
# eggNOG	KOG0637	Eukaryota
BLAST	swissprot:S45A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S45A1_HUMAN
BioCyc	ZFISH:ENSG00000162426-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000162426-MONOMER
CleanEx	HS_SLC45A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC45A1
DOI	10.1006/geno.1999.6097	http://dx.doi.org/10.1006/geno.1999.6097
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
EMBL	AF118274	http://www.ebi.ac.uk/ena/data/view/AF118274
EMBL	AL356072	http://www.ebi.ac.uk/ena/data/view/AL356072
Ensembl	ENST00000289877	http://www.ensembl.org/id/ENST00000289877
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_process	GO:0008643	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008643
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC45A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC45A1
GeneTree	ENSGT00390000018882	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000018882
H-InvDB	HIX0028554	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0028554
HGNC	HGNC:17939	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17939
HOGENOM	HOG000231090	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231090&db=HOGENOM6
HOVERGEN	HBG053518	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053518&db=HOVERGEN
HPA	HPA053528	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA053528
HPA	HPA057766	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA057766
InParanoid	Q9Y2W3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y2W3
IntAct	Q9Y2W3	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9Y2W3*
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
MIM	605763	http://www.ncbi.nlm.nih.gov/omim/605763
PSORT	swissprot:S45A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S45A1_HUMAN
PSORT-B	swissprot:S45A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S45A1_HUMAN
PSORT2	swissprot:S45A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S45A1_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
Phobius	swissprot:S45A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S45A1_HUMAN
PhylomeDB	Q9Y2W3	http://phylomedb.org/?seqid=Q9Y2W3
ProteinModelPortal	Q9Y2W3	http://www.proteinmodelportal.org/query/uniprot/Q9Y2W3
PubMed	10729226	http://www.ncbi.nlm.nih.gov/pubmed/10729226
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
STRING	9606.ENSP00000289877	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000289877&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.2.4.10	http://www.tcdb.org/search/result.php?tc=2.A.2.4.10
UCSC	uc001apb	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001apb&org=rat
UniGene	Hs.463036	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.463036
UniProtKB	S45A1_HUMAN	http://www.uniprot.org/uniprot/S45A1_HUMAN
UniProtKB-AC	Q9Y2W3	http://www.uniprot.org/uniprot/Q9Y2W3
charge	swissprot:S45A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S45A1_HUMAN
eggNOG	ENOG410Y28T	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y28T
eggNOG	KOG0637	http://eggnogapi.embl.de/nog_data/html/tree/KOG0637
epestfind	swissprot:S45A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S45A1_HUMAN
garnier	swissprot:S45A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S45A1_HUMAN
helixturnhelix	swissprot:S45A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S45A1_HUMAN
hmoment	swissprot:S45A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S45A1_HUMAN
iep	swissprot:S45A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S45A1_HUMAN
inforesidue	swissprot:S45A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S45A1_HUMAN
neXtProt	NX_Q9Y2W3	http://www.nextprot.org/db/entry/NX_Q9Y2W3
octanol	swissprot:S45A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S45A1_HUMAN
pepcoil	swissprot:S45A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S45A1_HUMAN
pepdigest	swissprot:S45A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S45A1_HUMAN
pepinfo	swissprot:S45A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S45A1_HUMAN
pepnet	swissprot:S45A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S45A1_HUMAN
pepstats	swissprot:S45A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S45A1_HUMAN
pepwheel	swissprot:S45A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S45A1_HUMAN
pepwindow	swissprot:S45A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S45A1_HUMAN
sigcleave	swissprot:S45A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S45A1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	FUCT1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96A29-1; Sequence=Displayed; Name=2; IsoId=Q96A29-2; Sequence=VSP_047116; 
# AltName	FUCT1_HUMAN	Solute carrier family 35 member C1
# CCDS	CCDS44575	-. [Q96A29-2]
# CCDS	CCDS7914	-. [Q96A29-1]
# DISEASE	FUCT1_HUMAN	Congenital disorder of glycosylation 2C (CDG2C) [MIM 266265]  A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N- glycoproteins during embryonic development, differentiation, and maintenance of cell functions. The clinical features of CDG2C include mental retardation, short stature, facial stigmata, and recurrent bacterial peripheral infections with persistently elevated peripheral leukocytes. Biochemically, CDG2C is characterized by a lack of fucosylated glycoconjugates, including selectin ligands. {ECO 0000269|PubMed 11326279, ECO 0000269|PubMed 11326280}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000314134	ENSP00000313318; ENSG00000181830. [Q96A29-1]
# Ensembl	ENST00000442528	ENSP00000412408; ENSG00000181830. [Q96A29-2]
# ExpressionAtlas	Q96A29	baseline and differential
# FUNCTION	FUCT1_HUMAN	Involved in GDP-fucose import from the cytoplasm into the Golgi lumen. 
# GO_component	GO:0000139	Golgi membrane; TAS:Reactome.
# GO_component	GO:0005794	Golgi apparatus; IDA:HPA.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005457	GDP-fucose transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0008643	carbohydrate transport; IEA:UniProtKB-KW.
# GO_process	GO:0030259	lipid glycosylation; IEA:Ensembl.
# GO_process	GO:0045746	negative regulation of Notch signaling pathway; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q96A29	HS
# HGNC	HGNC:20197	SLC35C1
# InterPro	IPR004853	Sugar_P_trans_dom
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H00099	[Primary immunodeficiency] LAD with Rac2 deficiency
# KEGG_Disease	H00119	[Inherited metabolic disease] Congenital disorders of glycosylation (CDG) type II
# MIM	266265	phenotype
# MIM	605881	gene
# Organism	FUCT1_HUMAN	Homo sapiens (Human)
# Orphanet	99843	Leukocyte adhesion deficiency type II
# Pfam	PF03151	TPT
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-6787639	GDP-fucose biosynthesis
# Reactome	R-HSA-727802	Transport of nucleotide sugars
# RecName	FUCT1_HUMAN	GDP-fucose transporter 1
# RefSeq	NP_001138737	NM_001145265.1. [Q96A29-2]
# RefSeq	NP_001138738	NM_001145266.1. [Q96A29-2]
# RefSeq	NP_060859	NM_018389.4. [Q96A29-1]
# SEQUENCE CAUTION	Sequence=BAA92126.1; Type=Erroneous initiation; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the TPT transporter family. SLC35C subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	FUCT1_HUMAN	Golgi apparatus membrane; Multi-pass membrane protein. 
# TCDB	2.A.7.16	the drug/metabolite transporter (dmt) superfamily
# UCSC	uc001nbo	human. [Q96A29-1]
# WEB RESOURCE	FUCT1_HUMAN	Name=SLC35C1base; Note=SLC35C1 mutation db; URL="http //structure.bmc.lu.se/idbase/SLC35C1base/";
# eggNOG	ENOG410XST0	LUCA
# eggNOG	KOG1442	Eukaryota
BLAST	swissprot:FUCT1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:FUCT1_HUMAN
BioCyc	ZFISH:ENSG00000181830-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000181830-MONOMER
COXPRESdb	55343	http://coxpresdb.jp/data/gene/55343.shtml
CleanEx	HS_SLC35C1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC35C1
DOI	10.1038/88289	http://dx.doi.org/10.1038/88289
DOI	10.1038/88299	http://dx.doi.org/10.1038/88299
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC044839	http://www.ebi.ac.uk/ena/data/view/AC044839
EMBL	AF323970	http://www.ebi.ac.uk/ena/data/view/AF323970
EMBL	AF326199	http://www.ebi.ac.uk/ena/data/view/AF326199
EMBL	AK002182	http://www.ebi.ac.uk/ena/data/view/AK002182
EMBL	AK027394	http://www.ebi.ac.uk/ena/data/view/AK027394
EMBL	AK315473	http://www.ebi.ac.uk/ena/data/view/AK315473
EMBL	BC001427	http://www.ebi.ac.uk/ena/data/view/BC001427
EMBL	CH471064	http://www.ebi.ac.uk/ena/data/view/CH471064
Ensembl	ENST00000314134	http://www.ensembl.org/id/ENST00000314134
Ensembl	ENST00000442528	http://www.ensembl.org/id/ENST00000442528
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005457	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005457
GO_process	GO:0008643	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008643
GO_process	GO:0030259	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030259
GO_process	GO:0045746	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045746
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	SLC35C1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC35C1
GeneID	55343	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55343
GeneTree	ENSGT00390000013315	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000013315
HGNC	HGNC:20197	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20197
HOGENOM	HOG000021132	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000021132&db=HOGENOM6
HOVERGEN	HBG051670	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051670&db=HOVERGEN
HPA	HPA064001	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA064001
InParanoid	Q96A29	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96A29
InterPro	IPR004853	http://www.ebi.ac.uk/interpro/entry/IPR004853
Jabion	55343	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55343
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00099	http://www.genome.jp/dbget-bin/www_bget?H00099
KEGG_Disease	H00119	http://www.genome.jp/dbget-bin/www_bget?H00119
KEGG_Gene	hsa:55343	http://www.genome.jp/dbget-bin/www_bget?hsa:55343
KEGG_Orthology	KO:K15279	http://www.genome.jp/dbget-bin/www_bget?KO:K15279
MIM	266265	http://www.ncbi.nlm.nih.gov/omim/266265
MIM	605881	http://www.ncbi.nlm.nih.gov/omim/605881
OMA	VVSLYWV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VVSLYWV
Orphanet	99843	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=99843
OrthoDB	EOG091G0CH6	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0CH6
PSORT	swissprot:FUCT1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:FUCT1_HUMAN
PSORT-B	swissprot:FUCT1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:FUCT1_HUMAN
PSORT2	swissprot:FUCT1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:FUCT1_HUMAN
Pfam	PF03151	http://pfam.xfam.org/family/PF03151
PharmGKB	PA134930330	http://www.pharmgkb.org/do/serve?objId=PA134930330&objCls=Gene
Phobius	swissprot:FUCT1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:FUCT1_HUMAN
PhylomeDB	Q96A29	http://phylomedb.org/?seqid=Q96A29
ProteinModelPortal	Q96A29	http://www.proteinmodelportal.org/query/uniprot/Q96A29
PubMed	11326279	http://www.ncbi.nlm.nih.gov/pubmed/11326279
PubMed	11326280	http://www.ncbi.nlm.nih.gov/pubmed/11326280
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
Reactome	R-HSA-6787639	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6787639
Reactome	R-HSA-727802	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-727802
RefSeq	NP_001138737	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001138737
RefSeq	NP_001138738	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001138738
RefSeq	NP_060859	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060859
STRING	9606.ENSP00000313318	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000313318&targetmode=cogs
TCDB	2.A.7.16	http://www.tcdb.org/search/result.php?tc=2.A.7.16
UCSC	uc001nbo	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001nbo&org=rat
UniGene	Hs.12211	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.12211
UniProtKB	FUCT1_HUMAN	http://www.uniprot.org/uniprot/FUCT1_HUMAN
UniProtKB-AC	Q96A29	http://www.uniprot.org/uniprot/Q96A29
charge	swissprot:FUCT1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:FUCT1_HUMAN
eggNOG	ENOG410XST0	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XST0
eggNOG	KOG1442	http://eggnogapi.embl.de/nog_data/html/tree/KOG1442
epestfind	swissprot:FUCT1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:FUCT1_HUMAN
garnier	swissprot:FUCT1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:FUCT1_HUMAN
helixturnhelix	swissprot:FUCT1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:FUCT1_HUMAN
hmoment	swissprot:FUCT1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:FUCT1_HUMAN
iep	swissprot:FUCT1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:FUCT1_HUMAN
inforesidue	swissprot:FUCT1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:FUCT1_HUMAN
neXtProt	NX_Q96A29	http://www.nextprot.org/db/entry/NX_Q96A29
octanol	swissprot:FUCT1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:FUCT1_HUMAN
pepcoil	swissprot:FUCT1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:FUCT1_HUMAN
pepdigest	swissprot:FUCT1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:FUCT1_HUMAN
pepinfo	swissprot:FUCT1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:FUCT1_HUMAN
pepnet	swissprot:FUCT1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:FUCT1_HUMAN
pepstats	swissprot:FUCT1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:FUCT1_HUMAN
pepwheel	swissprot:FUCT1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:FUCT1_HUMAN
pepwindow	swissprot:FUCT1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:FUCT1_HUMAN
sigcleave	swissprot:FUCT1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:FUCT1_HUMAN
## Database	ID	URL or Descriptions
# AltName	AT5G1_HUMAN	ATP synthase lipid-binding protein
# AltName	AT5G1_HUMAN	ATP synthase proteolipid P1
# AltName	AT5G1_HUMAN	ATP synthase proton-transporting mitochondrial F(0) complex subunit C1
# AltName	AT5G1_HUMAN	ATPase protein 9
# AltName	AT5G1_HUMAN	ATPase subunit c
# BioGrid	107001	8
# Ensembl	ENST00000355938	ENSP00000348205; ENSG00000159199
# Ensembl	ENST00000393366	ENSP00000377033; ENSG00000159199
# ExpressionAtlas	P05496	baseline and differential
# FUNCTION	AT5G1_HUMAN	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element. 
# GO_component	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); IBA:GO_Central.
# GO_component	GO:0005739	mitochondrion; IDA:LIFEdb.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0005753	mitochondrial proton-transporting ATP synthase complex; ISS:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005215	transporter activity; NAS:ProtInc.
# GO_function	GO:0008289	lipid binding; IEA:UniProtKB-KW.
# GO_function	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism; IBA:GO_Central.
# GO_process	GO:0006754	ATP biosynthetic process; TAS:Reactome.
# GO_process	GO:0015986	ATP synthesis coupled proton transport; IBA:GO_Central.
# GO_process	GO:0015991	ATP hydrolysis coupled proton transport; IEA:InterPro.
# GO_process	GO:0042776	mitochondrial ATP synthesis coupled proton transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008289	lipid binding
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.20.10	-; 1.
# Genevisible	P05496	HS
# HAMAP	MF_01396	ATP_synth_c_bact
# HGNC	HGNC:841	ATP5G1
# INTERACTION	AT5G1_HUMAN	Q86WT6 TRIM69; NbExp=3; IntAct=EBI-10194585, EBI-749955; 
# InterPro	IPR000454	ATP_synth_F0_csu
# InterPro	IPR002379	ATPase_proteolipid_c-like_dom
# InterPro	IPR020537	ATP_synth_F0_csu_DDCD_BS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	603192	gene
# MISCELLANEOUS	AT5G1_HUMAN	There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins. Is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease). 
# Organism	AT5G1_HUMAN	Homo sapiens (Human)
# PIR	S34066	S34066
# PRINTS	PR00124	ATPASEC
# PROSITE	PS00605	ATPASE_C
# Pfam	PF00137	ATP-synt_C
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-1268020	Mitochondrial protein import
# Reactome	R-HSA-163210	Formation of ATP by chemiosmotic coupling
# RecName	AT5G1_HUMAN	ATP synthase F(0) complex subunit C1, mitochondrial
# RefSeq	NP_001002027	NM_001002027.1
# RefSeq	NP_005166	NM_005175.2
# SIMILARITY	Belongs to the ATPase C chain family. {ECO	0000305}.
# SUBCELLULAR LOCATION	AT5G1_HUMAN	Mitochondrion membrane; Multi-pass membrane protein. 
# SUBUNIT	F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits	 a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity). {ECO:0000250}. 
# SUPFAM	SSF81333	SSF81333
# eggNOG	COG0636	LUCA
# eggNOG	KOG3025	Eukaryota
BLAST	swissprot:AT5G1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AT5G1_HUMAN
BioCyc	ZFISH:ENSG00000159199-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000159199-MONOMER
COG	COG0636	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0636
COXPRESdb	516	http://coxpresdb.jp/data/gene/516.shtml
CleanEx	HS_ATP5G1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP5G1
DOI	10.1016/0006-291X(87)91446-X	http://dx.doi.org/10.1016/0006-291X(87)91446-X
DOI	10.1016/0167-4781(93)90249-D	http://dx.doi.org/10.1016/0167-4781(93)90249-D
DOI	10.1042/bj2930051	http://dx.doi.org/10.1042/bj2930051
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1101/gr.GR1547R	http://dx.doi.org/10.1101/gr.GR1547R
EMBL	AL080089	http://www.ebi.ac.uk/ena/data/view/AL080089
EMBL	BC004963	http://www.ebi.ac.uk/ena/data/view/BC004963
EMBL	BT007230	http://www.ebi.ac.uk/ena/data/view/BT007230
EMBL	D13118	http://www.ebi.ac.uk/ena/data/view/D13118
EMBL	M16453	http://www.ebi.ac.uk/ena/data/view/M16453
EMBL	X69907	http://www.ebi.ac.uk/ena/data/view/X69907
Ensembl	ENST00000355938	http://www.ensembl.org/id/ENST00000355938
Ensembl	ENST00000393366	http://www.ensembl.org/id/ENST00000393366
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000276
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005753	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005753
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GO_function	GO:0046933	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046933
GO_process	GO:0006754	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006754
GO_process	GO:0015986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015986
GO_process	GO:0015991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015991
GO_process	GO:0042776	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042776
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.20.10	http://www.cathdb.info/version/latest/superfamily/1.20.20.10
GeneCards	ATP5G1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP5G1
GeneID	516	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=516
GeneTree	ENSGT00390000006210	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000006210
HAMAP	MF_01396	http://hamap.expasy.org/unirule/MF_01396
HGNC	HGNC:841	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:841
HOGENOM	HOG000235246	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000235246&db=HOGENOM6
HOVERGEN	HBG050605	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050605&db=HOVERGEN
HPA	CAB004438	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB004438
InParanoid	P05496	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P05496
IntAct	P05496	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P05496*
InterPro	IPR000454	http://www.ebi.ac.uk/interpro/entry/IPR000454
InterPro	IPR002379	http://www.ebi.ac.uk/interpro/entry/IPR002379
InterPro	IPR020537	http://www.ebi.ac.uk/interpro/entry/IPR020537
Jabion	516	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=516
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:516	http://www.genome.jp/dbget-bin/www_bget?hsa:516
KEGG_Orthology	KO:K02128	http://www.genome.jp/dbget-bin/www_bget?KO:K02128
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	603192	http://www.ncbi.nlm.nih.gov/omim/603192
OMA	PPALIRC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PPALIRC
OrthoDB	EOG091G13J1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G13J1
PRINTS	PR00124	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00124
PROSITE	PS00605	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00605
PSORT	swissprot:AT5G1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AT5G1_HUMAN
PSORT-B	swissprot:AT5G1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AT5G1_HUMAN
PSORT2	swissprot:AT5G1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AT5G1_HUMAN
Pfam	PF00137	http://pfam.xfam.org/family/PF00137
PharmGKB	PA25131	http://www.pharmgkb.org/do/serve?objId=PA25131&objCls=Gene
Phobius	swissprot:AT5G1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AT5G1_HUMAN
PhylomeDB	P05496	http://phylomedb.org/?seqid=P05496
ProteinModelPortal	P05496	http://www.proteinmodelportal.org/query/uniprot/P05496
PubMed	11230166	http://www.ncbi.nlm.nih.gov/pubmed/11230166
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	2883974	http://www.ncbi.nlm.nih.gov/pubmed/2883974
PubMed	8328972	http://www.ncbi.nlm.nih.gov/pubmed/8328972
PubMed	8485160	http://www.ncbi.nlm.nih.gov/pubmed/8485160
Reactome	R-HSA-1268020	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1268020
Reactome	R-HSA-163210	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-163210
RefSeq	NP_001002027	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001002027
RefSeq	NP_005166	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005166
STRING	9606.ENSP00000348205	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000348205&targetmode=cogs
STRING	COG0636	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0636&targetmode=cogs
SUPFAM	SSF81333	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81333
UniGene	Hs.80986	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.80986
UniProtKB	AT5G1_HUMAN	http://www.uniprot.org/uniprot/AT5G1_HUMAN
UniProtKB-AC	P05496	http://www.uniprot.org/uniprot/P05496
charge	swissprot:AT5G1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AT5G1_HUMAN
eggNOG	COG0636	http://eggnogapi.embl.de/nog_data/html/tree/COG0636
eggNOG	KOG3025	http://eggnogapi.embl.de/nog_data/html/tree/KOG3025
epestfind	swissprot:AT5G1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AT5G1_HUMAN
garnier	swissprot:AT5G1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AT5G1_HUMAN
helixturnhelix	swissprot:AT5G1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AT5G1_HUMAN
hmoment	swissprot:AT5G1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AT5G1_HUMAN
iep	swissprot:AT5G1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AT5G1_HUMAN
inforesidue	swissprot:AT5G1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AT5G1_HUMAN
neXtProt	NX_P05496	http://www.nextprot.org/db/entry/NX_P05496
octanol	swissprot:AT5G1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AT5G1_HUMAN
pepcoil	swissprot:AT5G1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AT5G1_HUMAN
pepdigest	swissprot:AT5G1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AT5G1_HUMAN
pepinfo	swissprot:AT5G1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AT5G1_HUMAN
pepnet	swissprot:AT5G1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AT5G1_HUMAN
pepstats	swissprot:AT5G1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AT5G1_HUMAN
pepwheel	swissprot:AT5G1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AT5G1_HUMAN
pepwindow	swissprot:AT5G1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AT5G1_HUMAN
sigcleave	swissprot:AT5G1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AT5G1_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	132529	2
# Ensembl	ENST00000360945	ENSP00000354204; ENSG00000196860
# ExpressionAtlas	Q6UXN7	baseline and differential
# GO_component	GO:0005742	mitochondrial outer membrane translocase complex; IBA:GO_Central.
# GO_component	GO:0031307	integral component of mitochondrial outer membrane; IBA:GO_Central.
# GO_function	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0030943	mitochondrion targeting sequence binding; IBA:GO_Central.
# GO_process	GO:0016031	tRNA import into mitochondrion; IBA:GO_Central.
# GO_process	GO:0030150	protein import into mitochondrial matrix; IBA:GO_Central.
# GO_process	GO:0070096	mitochondrial outer membrane translocase complex assembly; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.960.10	-; 1.
# HGNC	HGNC:33752	TOMM20L
# InterPro	IPR002056	MAS20
# InterPro	IPR022422	MAS20_rcpt_metazoan
# InterPro	IPR023392	Tom20_dom
# Organism	TO20L_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12430	PTHR12430
# PIRSF	PIRSF037707	MAS20_rcpt
# PRINTS	PR00351	OM20RECEPTOR
# PRINTS	PR01989	EUOM20RECPTR
# Pfam	PF02064	MAS20
# Proteomes	UP000005640	Chromosome 14
# RecName	TO20L_HUMAN	TOMM20-like protein 1
# RefSeq	NP_997260	NM_207377.2
# SIMILARITY	Belongs to the Tom20 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	TO20L_HUMAN	Mitochondrion outer membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF47157	SSF47157
# UCSC	uc001xdr	human
# eggNOG	ENOG4111NAH	LUCA
# eggNOG	KOG4056	Eukaryota
BLAST	swissprot:TO20L_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TO20L_HUMAN
BioCyc	ZFISH:G66-33497-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33497-MONOMER
COXPRESdb	387990	http://coxpresdb.jp/data/gene/387990.shtml
CleanEx	HS_TOMM20L	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TOMM20L
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AY358266	http://www.ebi.ac.uk/ena/data/view/AY358266
EMBL	BC137557	http://www.ebi.ac.uk/ena/data/view/BC137557
EMBL	BC137563	http://www.ebi.ac.uk/ena/data/view/BC137563
EMBL	CH471061	http://www.ebi.ac.uk/ena/data/view/CH471061
Ensembl	ENST00000360945	http://www.ensembl.org/id/ENST00000360945
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005742	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005742
GO_component	GO:0031307	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031307
GO_function	GO:0015450	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015450
GO_function	GO:0030943	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030943
GO_process	GO:0016031	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016031
GO_process	GO:0030150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030150
GO_process	GO:0070096	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070096
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.960.10	http://www.cathdb.info/version/latest/superfamily/1.20.960.10
GeneCards	TOMM20L	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TOMM20L
GeneID	387990	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=387990
GeneTree	ENSGT00390000011698	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000011698
HGNC	HGNC:33752	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:33752
HOGENOM	HOG000006671	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006671&db=HOGENOM6
HOVERGEN	HBG057315	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG057315&db=HOVERGEN
HPA	HPA044997	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA044997
InParanoid	Q6UXN7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6UXN7
IntAct	Q6UXN7	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q6UXN7*
InterPro	IPR002056	http://www.ebi.ac.uk/interpro/entry/IPR002056
InterPro	IPR022422	http://www.ebi.ac.uk/interpro/entry/IPR022422
InterPro	IPR023392	http://www.ebi.ac.uk/interpro/entry/IPR023392
Jabion	387990	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=387990
KEGG_Gene	hsa:387990	http://www.genome.jp/dbget-bin/www_bget?hsa:387990
OMA	DKRRAEP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DKRRAEP
OrthoDB	EOG091G0Z80	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0Z80
PANTHER	PTHR12430	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12430
PRINTS	PR00351	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00351
PRINTS	PR01989	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01989
PSORT	swissprot:TO20L_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TO20L_HUMAN
PSORT-B	swissprot:TO20L_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TO20L_HUMAN
PSORT2	swissprot:TO20L_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TO20L_HUMAN
Pfam	PF02064	http://pfam.xfam.org/family/PF02064
PharmGKB	PA162406689	http://www.pharmgkb.org/do/serve?objId=PA162406689&objCls=Gene
Phobius	swissprot:TO20L_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TO20L_HUMAN
PhylomeDB	Q6UXN7	http://phylomedb.org/?seqid=Q6UXN7
ProteinModelPortal	Q6UXN7	http://www.proteinmodelportal.org/query/uniprot/Q6UXN7
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
RefSeq	NP_997260	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_997260
SMR	Q6UXN7	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q6UXN7
STRING	9606.ENSP00000354204	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000354204&targetmode=cogs
SUPFAM	SSF47157	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47157
UCSC	uc001xdr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001xdr&org=rat
UniGene	Hs.592307	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.592307
UniProtKB	TO20L_HUMAN	http://www.uniprot.org/uniprot/TO20L_HUMAN
UniProtKB-AC	Q6UXN7	http://www.uniprot.org/uniprot/Q6UXN7
charge	swissprot:TO20L_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TO20L_HUMAN
eggNOG	ENOG4111NAH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111NAH
eggNOG	KOG4056	http://eggnogapi.embl.de/nog_data/html/tree/KOG4056
epestfind	swissprot:TO20L_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TO20L_HUMAN
garnier	swissprot:TO20L_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TO20L_HUMAN
helixturnhelix	swissprot:TO20L_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TO20L_HUMAN
hmoment	swissprot:TO20L_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TO20L_HUMAN
iep	swissprot:TO20L_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TO20L_HUMAN
inforesidue	swissprot:TO20L_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TO20L_HUMAN
neXtProt	NX_Q6UXN7	http://www.nextprot.org/db/entry/NX_Q6UXN7
octanol	swissprot:TO20L_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TO20L_HUMAN
pepcoil	swissprot:TO20L_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TO20L_HUMAN
pepdigest	swissprot:TO20L_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TO20L_HUMAN
pepinfo	swissprot:TO20L_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TO20L_HUMAN
pepnet	swissprot:TO20L_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TO20L_HUMAN
pepstats	swissprot:TO20L_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TO20L_HUMAN
pepwheel	swissprot:TO20L_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TO20L_HUMAN
pepwindow	swissprot:TO20L_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TO20L_HUMAN
sigcleave	swissprot:TO20L_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TO20L_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNJ1_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=ROM-K1; IsoId=P48048-1; Sequence=Displayed; Name=2; Synonyms=2-4-5, ROM-K2, ROM-K4, ROM-K5, ROM-K6; IsoId=P48048-2; Sequence=VSP_002797; Name=3; Synonyms=ROM-K3; IsoId=P48048-3; Sequence=VSP_002798; 
# AltName	KCNJ1_HUMAN	ATP-regulated potassium channel ROM-K
# AltName	KCNJ1_HUMAN	Inward rectifier K(+) channel Kir1.1
# AltName	KCNJ1_HUMAN	Potassium channel, inwardly rectifying subfamily J member 1
# BioGrid	109960	4
# CCDS	CCDS8476	-. [P48048-1]
# CCDS	CCDS8477	-. [P48048-2]
# DISEASE	KCNJ1_HUMAN	Bartter syndrome 2, antenatal (BARTS2) [MIM 241200]  A form of Bartter syndrome, an autosomal recessive disorder characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BARTS2 is a life-threatening condition beginning in utero, with marked fetal polyuria that leads to polyhydramnios and premature delivery. Another hallmark is a marked hypercalciuria and, as a secondary consequence, the development of nephrocalcinosis and osteopenia. {ECO 0000269|PubMed 8841184, ECO 0000269|PubMed 9002665, ECO 0000269|PubMed 9727001}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00217	Bethanidine
# DrugBank	DB00222	Glimepiride
# DrugBank	DB00350	Minoxidil
# DrugBank	DB00839	Tolazamide
# DrugBank	DB01016	Glyburide
# DrugBank	DB01124	Tolbutamide
# DrugBank	DB01382	Glycodiazine
# DrugBank	DB01392	Yohimbine
# ENZYME REGULATION	Inhibited by WNK3. {ECO:0000269|PubMed	16357011}. 
# Ensembl	ENST00000324036	ENSP00000316233; ENSG00000151704. [P48048-2]
# Ensembl	ENST00000392664	ENSP00000376432; ENSG00000151704. [P48048-1]
# Ensembl	ENST00000392665	ENSP00000376433; ENSG00000151704. [P48048-2]
# Ensembl	ENST00000392666	ENSP00000376434; ENSG00000151704. [P48048-2]
# Ensembl	ENST00000440599	ENSP00000406320; ENSG00000151704. [P48048-2]
# ExpressionAtlas	P48048	baseline and differential
# FUNCTION	KCNJ1_HUMAN	In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008076	voltage-gated potassium channel complex; TAS:ProtInc.
# GO_function	GO:0005242	inward rectifier potassium channel activity; TAS:Reactome.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding; IDA:BHF-UCL.
# GO_function	GO:0015272	ATP-activated inward rectifier potassium channel activity; IBA:GO_Central.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0007588	excretion; TAS:ProtInc.
# GO_process	GO:0010107	potassium ion import; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0008289	lipid binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.40.1400	-; 1.
# Genevisible	P48048	HS
# HGNC	HGNC:6255	KCNJ1
# InterPro	IPR003268	K_chnl_inward-rec_Kir1.1
# InterPro	IPR013518	K_chnl_inward-rec_Kir_cyto
# InterPro	IPR014756	Ig_E-set
# InterPro	IPR016449	K_chnl_inward-rec_Kir
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00239	[Endocrine disease; Urinary system disease] Bartter syndrome
# KEGG_Pathway	ko04960	Aldosterone-regulated sodium reabsorption
# KEGG_Pathway	ko04971	Gastric acid secretion
# MIM	241200	phenotype
# MIM	600359	gene
# Organism	KCNJ1_HUMAN	Homo sapiens (Human)
# Orphanet	93604	Antenatal Bartter syndrome
# PANTHER	PTHR11767	PTHR11767
# PANTHER	PTHR11767:SF6	PTHR11767:SF6
# PIR	A55119	A55119
# PIRSF	PIRSF005465	GIRK_kir
# PRINTS	PR01320	KIRCHANNEL
# PRINTS	PR01321	KIR11CHANNEL
# PTM	KCNJ1_HUMAN	Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane. {ECO 0000269|PubMed 12684516}. 
# Pfam	PF01007	IRK
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-1296067	Potassium transport channels
# RecName	KCNJ1_HUMAN	ATP-sensitive inward rectifier potassium channel 1
# RefSeq	NP_000211	NM_000220.4. [P48048-1]
# RefSeq	NP_722448	NM_153764.2. [P48048-2]
# RefSeq	NP_722449	NM_153765.2. [P48048-3]
# RefSeq	NP_722450	NM_153766.2. [P48048-2]
# RefSeq	NP_722451	NM_153767.3. [P48048-2]
# SIMILARITY	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ1 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCNJ1_HUMAN	Cell membrane {ECO 0000269|PubMed 12684516}; Multi-pass membrane protein {ECO 0000269|PubMed 12684516}. Note=Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane. 
# SUBUNIT	Interacts with SGK1 and SLC9A3R2/NHERF2. {ECO:0000269|PubMed	14623317}. 
# SUPFAM	SSF81296	SSF81296
# TCDB	1.A.2.1	inward rectifier k(+) channel (irk-c) family
# TISSUE SPECIFICITY	In the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver. {ECO:0000269|PubMed	7635463}. 
# UCSC	uc001qeo	human. [P48048-1]
# eggNOG	ENOG410XQ62	LUCA
# eggNOG	KOG3827	Eukaryota
BLAST	swissprot:KCNJ1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNJ1_HUMAN
BioCyc	ZFISH:ENSG00000151704-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000151704-MONOMER
COXPRESdb	3758	http://coxpresdb.jp/data/gene/3758.shtml
CleanEx	HS_KCNJ1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNJ1
DOI	10.1007/BF00207372	http://dx.doi.org/10.1007/BF00207372
DOI	10.1016/S0378-1119(96)00759-7	http://dx.doi.org/10.1016/S0378-1119(96)00759-7
DOI	10.1016/j.bbrc.2003.10.037	http://dx.doi.org/10.1016/j.bbrc.2003.10.037
DOI	10.1038/ng1096-152	http://dx.doi.org/10.1038/ng1096-152
DOI	10.1074/jbc.273.37.23884	http://dx.doi.org/10.1074/jbc.273.37.23884
DOI	10.1074/jbc.M005338200	http://dx.doi.org/10.1074/jbc.M005338200
DOI	10.1074/jbc.M212301200	http://dx.doi.org/10.1074/jbc.M212301200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1113/jphysiol.2005.102202	http://dx.doi.org/10.1113/jphysiol.2005.102202
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DrugBank	DB00217	http://www.drugbank.ca/drugs/DB00217
DrugBank	DB00222	http://www.drugbank.ca/drugs/DB00222
DrugBank	DB00350	http://www.drugbank.ca/drugs/DB00350
DrugBank	DB00839	http://www.drugbank.ca/drugs/DB00839
DrugBank	DB01016	http://www.drugbank.ca/drugs/DB01016
DrugBank	DB01124	http://www.drugbank.ca/drugs/DB01124
DrugBank	DB01382	http://www.drugbank.ca/drugs/DB01382
DrugBank	DB01392	http://www.drugbank.ca/drugs/DB01392
EMBL	BC074752	http://www.ebi.ac.uk/ena/data/view/BC074752
EMBL	BC136360	http://www.ebi.ac.uk/ena/data/view/BC136360
EMBL	BC136361	http://www.ebi.ac.uk/ena/data/view/BC136361
EMBL	CH471065	http://www.ebi.ac.uk/ena/data/view/CH471065
EMBL	S78737	http://www.ebi.ac.uk/ena/data/view/S78737
EMBL	U03884	http://www.ebi.ac.uk/ena/data/view/U03884
EMBL	U12541	http://www.ebi.ac.uk/ena/data/view/U12541
EMBL	U12542	http://www.ebi.ac.uk/ena/data/view/U12542
EMBL	U12543	http://www.ebi.ac.uk/ena/data/view/U12543
EMBL	U12544	http://www.ebi.ac.uk/ena/data/view/U12544
EMBL	U12545	http://www.ebi.ac.uk/ena/data/view/U12545
EMBL	U65406	http://www.ebi.ac.uk/ena/data/view/U65406
EMBL	U65406	http://www.ebi.ac.uk/ena/data/view/U65406
EMBL	U65406	http://www.ebi.ac.uk/ena/data/view/U65406
Ensembl	ENST00000324036	http://www.ensembl.org/id/ENST00000324036
Ensembl	ENST00000392664	http://www.ensembl.org/id/ENST00000392664
Ensembl	ENST00000392665	http://www.ensembl.org/id/ENST00000392665
Ensembl	ENST00000392666	http://www.ensembl.org/id/ENST00000392666
Ensembl	ENST00000440599	http://www.ensembl.org/id/ENST00000440599
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_function	GO:0005242	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005242
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0005546	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005546
GO_function	GO:0015272	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015272
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0007588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007588
GO_process	GO:0010107	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010107
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.40.1400	http://www.cathdb.info/version/latest/superfamily/2.60.40.1400
GeneCards	KCNJ1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNJ1
GeneID	3758	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3758
GeneTree	ENSGT00760000118842	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118842
HGNC	HGNC:6255	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6255
HOGENOM	HOG000237326	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237326&db=HOGENOM6
HOVERGEN	HBG006178	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006178&db=HOVERGEN
HPA	HPA026962	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA026962
InParanoid	P48048	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P48048
InterPro	IPR003268	http://www.ebi.ac.uk/interpro/entry/IPR003268
InterPro	IPR013518	http://www.ebi.ac.uk/interpro/entry/IPR013518
InterPro	IPR014756	http://www.ebi.ac.uk/interpro/entry/IPR014756
InterPro	IPR016449	http://www.ebi.ac.uk/interpro/entry/IPR016449
Jabion	3758	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3758
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00239	http://www.genome.jp/dbget-bin/www_bget?H00239
KEGG_Gene	hsa:3758	http://www.genome.jp/dbget-bin/www_bget?hsa:3758
KEGG_Orthology	KO:K04995	http://www.genome.jp/dbget-bin/www_bget?KO:K04995
KEGG_Pathway	ko04960	http://www.genome.jp/kegg-bin/show_pathway?ko04960
KEGG_Pathway	ko04971	http://www.genome.jp/kegg-bin/show_pathway?ko04971
MIM	241200	http://www.ncbi.nlm.nih.gov/omim/241200
MIM	600359	http://www.ncbi.nlm.nih.gov/omim/600359
MINT	MINT-90062	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-90062
OMA	WYAVAYI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WYAVAYI
Orphanet	93604	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=93604
OrthoDB	EOG091G08HC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08HC
PANTHER	PTHR11767	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11767
PANTHER	PTHR11767:SF6	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11767:SF6
PRINTS	PR01320	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01320
PRINTS	PR01321	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01321
PSORT	swissprot:KCNJ1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNJ1_HUMAN
PSORT-B	swissprot:KCNJ1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNJ1_HUMAN
PSORT2	swissprot:KCNJ1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNJ1_HUMAN
Pfam	PF01007	http://pfam.xfam.org/family/PF01007
PharmGKB	PA213	http://www.pharmgkb.org/do/serve?objId=PA213&objCls=Gene
Phobius	swissprot:KCNJ1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNJ1_HUMAN
PhylomeDB	P48048	http://phylomedb.org/?seqid=P48048
ProteinModelPortal	P48048	http://www.proteinmodelportal.org/query/uniprot/P48048
PubMed	10889209	http://www.ncbi.nlm.nih.gov/pubmed/10889209
PubMed	12684516	http://www.ncbi.nlm.nih.gov/pubmed/12684516
PubMed	14623317	http://www.ncbi.nlm.nih.gov/pubmed/14623317
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16357011	http://www.ncbi.nlm.nih.gov/pubmed/16357011
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	7635463	http://www.ncbi.nlm.nih.gov/pubmed/7635463
PubMed	7929082	http://www.ncbi.nlm.nih.gov/pubmed/7929082
PubMed	8190102	http://www.ncbi.nlm.nih.gov/pubmed/8190102
PubMed	8841184	http://www.ncbi.nlm.nih.gov/pubmed/8841184
PubMed	9002665	http://www.ncbi.nlm.nih.gov/pubmed/9002665
PubMed	9099852	http://www.ncbi.nlm.nih.gov/pubmed/9099852
PubMed	9727001	http://www.ncbi.nlm.nih.gov/pubmed/9727001
Reactome	R-HSA-1296067	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296067
RefSeq	NP_000211	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000211
RefSeq	NP_722448	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_722448
RefSeq	NP_722449	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_722449
RefSeq	NP_722450	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_722450
RefSeq	NP_722451	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_722451
SMR	P48048	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P48048
STRING	9606.ENSP00000376432	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000376432&targetmode=cogs
SUPFAM	SSF81296	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81296
TCDB	1.A.2.1	http://www.tcdb.org/search/result.php?tc=1.A.2.1
UCSC	uc001qeo	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001qeo&org=rat
UniGene	Hs.527830	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.527830
UniProtKB	KCNJ1_HUMAN	http://www.uniprot.org/uniprot/KCNJ1_HUMAN
UniProtKB-AC	P48048	http://www.uniprot.org/uniprot/P48048
charge	swissprot:KCNJ1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNJ1_HUMAN
eggNOG	ENOG410XQ62	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ62
eggNOG	KOG3827	http://eggnogapi.embl.de/nog_data/html/tree/KOG3827
epestfind	swissprot:KCNJ1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNJ1_HUMAN
garnier	swissprot:KCNJ1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNJ1_HUMAN
helixturnhelix	swissprot:KCNJ1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNJ1_HUMAN
hmoment	swissprot:KCNJ1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNJ1_HUMAN
iep	swissprot:KCNJ1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNJ1_HUMAN
inforesidue	swissprot:KCNJ1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNJ1_HUMAN
neXtProt	NX_P48048	http://www.nextprot.org/db/entry/NX_P48048
octanol	swissprot:KCNJ1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNJ1_HUMAN
pepcoil	swissprot:KCNJ1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNJ1_HUMAN
pepdigest	swissprot:KCNJ1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNJ1_HUMAN
pepinfo	swissprot:KCNJ1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNJ1_HUMAN
pepnet	swissprot:KCNJ1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNJ1_HUMAN
pepstats	swissprot:KCNJ1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNJ1_HUMAN
pepwheel	swissprot:KCNJ1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNJ1_HUMAN
pepwindow	swissprot:KCNJ1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNJ1_HUMAN
sigcleave	swissprot:KCNJ1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNJ1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	HVCN1_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q96D96-1; Sequence=Displayed; Name=2; IsoId=Q96D96-2; Sequence=VSP_034395; Name=3; IsoId=Q96D96-3; Sequence=VSP_034396; Note=No experimental confirmation available.; Name=4; IsoId=Q96D96-4; Sequence=VSP_045052; Note=No experimental confirmation available.; 
# AltName	HVCN1_HUMAN	Hydrogen voltage-gated channel 1
# AltName	HVCN1_HUMAN	Voltage sensor domain-only protein
# BioGrid	124053	8
# CCDS	CCDS31900	-. [Q96D96-1]
# CCDS	CCDS58278	-. [Q96D96-4]
# ChiTaRS	HVCN1	human
# DOMAIN	HVCN1_HUMAN	The C-terminal coiled coil region mediates homodimerization and cooperative channel gating. It is essential for normal subcellular localization. {ECO 0000269|PubMed 20147290}. 
# DOMAIN	HVCN1_HUMAN	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Unlike other voltage-gated ion channels it lacks the pore domain. {ECO 0000269|PubMed 20147290}. 
# ENZYME REGULATION	HVCN1_HUMAN	The dimers display cooperative channel gating (By similarity). The channel activity is inhibited by zinc ions. {ECO 0000250, ECO 0000269|PubMed 16554753, ECO 0000269|PubMed 22020278}. 
# Ensembl	ENST00000242607	ENSP00000242607; ENSG00000122986. [Q96D96-1]
# Ensembl	ENST00000356742	ENSP00000349181; ENSG00000122986. [Q96D96-1]
# Ensembl	ENST00000439744	ENSP00000412052; ENSG00000122986. [Q96D96-4]
# Ensembl	ENST00000548312	ENSP00000449601; ENSG00000122986. [Q96D96-3]
# Ensembl	ENST00000620084	ENSP00000479812; ENSG00000122986. [Q96D96-1]
# ExpressionAtlas	Q96D96	baseline and differential
# FUNCTION	HVCN1_HUMAN	Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis. {ECO 0000269|PubMed 16554753, ECO 0000269|PubMed 20037153, ECO 0000269|PubMed 22020278}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IDA:HGNC.
# GO_function	GO:0022843	voltage-gated cation channel activity; TAS:Reactome.
# GO_function	GO:0030171	voltage-gated proton channel activity; IDA:UniProtKB.
# GO_process	GO:0009268	response to pH; ISS:HGNC.
# GO_process	GO:0010043	response to zinc ion; IDA:HGNC.
# GO_process	GO:0015992	proton transport; IDA:UniProtKB.
# GO_process	GO:0035036	sperm-egg recognition; TAS:Reactome.
# GO_process	GO:0071294	cellular response to zinc ion; IDA:UniProtKB.
# GO_process	GO:0071467	cellular response to pH; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.20.120.350	-; 1.
# Genevisible	Q96D96	HS
# HGNC	HGNC:28240	HVCN1
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR031844	VGPC1_C
# MIM	611227	gene
# Organism	HVCN1_HUMAN	Homo sapiens (Human)
# PDB	3A2A	X-ray; 2.00 A; A/B/C/D=221-273
# PTM	HVCN1_HUMAN	Phosphorylation may enhance channel gating. {ECO 0000269|PubMed 20037153}. 
# Pfam	PF00520	Ion_trans
# Pfam	PF16799	VGPC1_C
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-1300642	Sperm Motility And Taxes
# Reactome	R-HSA-6798695	Neutrophil degranulation
# RecName	HVCN1_HUMAN	Voltage-gated hydrogen channel 1
# RefSeq	NP_001035196	NM_001040107.1. [Q96D96-1]
# RefSeq	NP_001243342	NM_001256413.1. [Q96D96-4]
# RefSeq	NP_115745	NM_032369.3. [Q96D96-1]
# RefSeq	XP_005254005	XM_005253948.2. [Q96D96-1]
# RefSeq	XP_011537147	XM_011538845.1. [Q96D96-1]
# RefSeq	XP_011537148	XM_011538846.2. [Q96D96-1]
# RefSeq	XP_011537149	XM_011538847.1. [Q96D96-1]
# RefSeq	XP_016875516	XM_017020027.1. [Q96D96-1]
# SEQUENCE CAUTION	Sequence=AAQ89413.1; Type=Frameshift; Positions=164, 175; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the hydrogen channel family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	HVCN1_HUMAN	Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Detected mainly at intracellular membranes upon overexpression in HeLa cells (PuMed 20147290), but not in other cell types. 
# SUBUNIT	Homodimer. {ECO:0000269|PubMed	20147290}. 
# TCDB	1.A.51.1	the voltage-gated proton channel (vpc) family
# TISSUE SPECIFICITY	Enriched in immune tissues, such as lymph nodes, B-lymphocytes, monocytes and spleen. {ECO:0000269|PubMed	16554753}. 
# UCSC	uc001trq	human. [Q96D96-1]
# eggNOG	ENOG410IKBG	Eukaryota
# eggNOG	ENOG4111XHU	LUCA
BLAST	swissprot:HVCN1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:HVCN1_HUMAN
BioCyc	ZFISH:ENSG00000122986-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000122986-MONOMER
COXPRESdb	84329	http://coxpresdb.jp/data/gene/84329.shtml
CleanEx	HS_HVCN1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_HVCN1
DIP	DIP-46112N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-46112N
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1038/nature04700	http://dx.doi.org/10.1038/nature04700
DOI	10.1038/nature10557	http://dx.doi.org/10.1038/nature10557
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.C109.082727	http://dx.doi.org/10.1074/jbc.C109.082727
DOI	10.1074/jbc.M109.040360	http://dx.doi.org/10.1074/jbc.M109.040360
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC144522	http://www.ebi.ac.uk/ena/data/view/AC144522
EMBL	AK293543	http://www.ebi.ac.uk/ena/data/view/AK293543
EMBL	AY359054	http://www.ebi.ac.uk/ena/data/view/AY359054
EMBL	BC007277	http://www.ebi.ac.uk/ena/data/view/BC007277
EMBL	BC009731	http://www.ebi.ac.uk/ena/data/view/BC009731
EMBL	BC032672	http://www.ebi.ac.uk/ena/data/view/BC032672
EMBL	CH471054	http://www.ebi.ac.uk/ena/data/view/CH471054
EMBL	CH471054	http://www.ebi.ac.uk/ena/data/view/CH471054
Ensembl	ENST00000242607	http://www.ensembl.org/id/ENST00000242607
Ensembl	ENST00000356742	http://www.ensembl.org/id/ENST00000356742
Ensembl	ENST00000439744	http://www.ensembl.org/id/ENST00000439744
Ensembl	ENST00000548312	http://www.ensembl.org/id/ENST00000548312
Ensembl	ENST00000620084	http://www.ensembl.org/id/ENST00000620084
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0022843	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022843
GO_function	GO:0030171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030171
GO_process	GO:0009268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009268
GO_process	GO:0010043	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010043
GO_process	GO:0015992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992
GO_process	GO:0035036	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035036
GO_process	GO:0071294	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071294
GO_process	GO:0071467	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071467
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	HVCN1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=HVCN1
GeneID	84329	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84329
GeneTree	ENSGT00530000063670	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063670
H-InvDB	HIX0011039	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0011039
HGNC	HGNC:28240	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:28240
HOGENOM	HOG000067871	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000067871&db=HOGENOM6
HOVERGEN	HBG102207	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG102207&db=HOVERGEN
HPA	HPA039329	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA039329
InParanoid	Q96D96	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96D96
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR031844	http://www.ebi.ac.uk/interpro/entry/IPR031844
Jabion	84329	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=84329
KEGG_Gene	hsa:84329	http://www.genome.jp/dbget-bin/www_bget?hsa:84329
MIM	611227	http://www.ncbi.nlm.nih.gov/omim/611227
MINT	MINT-4724965	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4724965
OMA	RMSKFLK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RMSKFLK
OrthoDB	EOG091G0L8G	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0L8G
PDB	3A2A	http://www.ebi.ac.uk/pdbe-srv/view/entry/3A2A
PDBsum	3A2A	http://www.ebi.ac.uk/pdbsum/3A2A
PSORT	swissprot:HVCN1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:HVCN1_HUMAN
PSORT-B	swissprot:HVCN1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:HVCN1_HUMAN
PSORT2	swissprot:HVCN1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:HVCN1_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF16799	http://pfam.xfam.org/family/PF16799
PharmGKB	PA144596422	http://www.pharmgkb.org/do/serve?objId=PA144596422&objCls=Gene
Phobius	swissprot:HVCN1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:HVCN1_HUMAN
PhylomeDB	Q96D96	http://phylomedb.org/?seqid=Q96D96
ProteinModelPortal	Q96D96	http://www.proteinmodelportal.org/query/uniprot/Q96D96
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	16554753	http://www.ncbi.nlm.nih.gov/pubmed/16554753
PubMed	20037153	http://www.ncbi.nlm.nih.gov/pubmed/20037153
PubMed	20147290	http://www.ncbi.nlm.nih.gov/pubmed/20147290
PubMed	22020278	http://www.ncbi.nlm.nih.gov/pubmed/22020278
Reactome	R-HSA-1300642	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1300642
Reactome	R-HSA-6798695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6798695
RefSeq	NP_001035196	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001035196
RefSeq	NP_001243342	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243342
RefSeq	NP_115745	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_115745
RefSeq	XP_005254005	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005254005
RefSeq	XP_011537147	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011537147
RefSeq	XP_011537148	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011537148
RefSeq	XP_011537149	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011537149
RefSeq	XP_016875516	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016875516
SMR	Q96D96	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q96D96
STRING	9606.ENSP00000242607	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000242607&targetmode=cogs
TCDB	1.A.51.1	http://www.tcdb.org/search/result.php?tc=1.A.51.1
UCSC	uc001trq	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001trq&org=rat
UniGene	Hs.211511	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.211511
UniGene	Hs.334637	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.334637
UniProtKB	HVCN1_HUMAN	http://www.uniprot.org/uniprot/HVCN1_HUMAN
UniProtKB-AC	Q96D96	http://www.uniprot.org/uniprot/Q96D96
charge	swissprot:HVCN1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:HVCN1_HUMAN
eggNOG	ENOG410IKBG	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IKBG
eggNOG	ENOG4111XHU	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111XHU
epestfind	swissprot:HVCN1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:HVCN1_HUMAN
garnier	swissprot:HVCN1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:HVCN1_HUMAN
helixturnhelix	swissprot:HVCN1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:HVCN1_HUMAN
hmoment	swissprot:HVCN1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:HVCN1_HUMAN
iep	swissprot:HVCN1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:HVCN1_HUMAN
inforesidue	swissprot:HVCN1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:HVCN1_HUMAN
neXtProt	NX_Q96D96	http://www.nextprot.org/db/entry/NX_Q96D96
octanol	swissprot:HVCN1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:HVCN1_HUMAN
pepcoil	swissprot:HVCN1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:HVCN1_HUMAN
pepdigest	swissprot:HVCN1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:HVCN1_HUMAN
pepinfo	swissprot:HVCN1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:HVCN1_HUMAN
pepnet	swissprot:HVCN1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:HVCN1_HUMAN
pepstats	swissprot:HVCN1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:HVCN1_HUMAN
pepwheel	swissprot:HVCN1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:HVCN1_HUMAN
pepwindow	swissprot:HVCN1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:HVCN1_HUMAN
sigcleave	swissprot:HVCN1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:HVCN1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AT2B4_HUMAN	Event=Alternative splicing; Named isoforms=8; Comment=There is a combination of two alternatively spliced domains at N-terminal site A (X and Z) and at C-terminal site B/C (A, B, D and K). The splice sites have mostly been studied independently. Full isoforms so far detected are isoform XA and isoform XB. Experimental confirmation may be lacking for some isoforms.; Name=XD; Synonyms=AIICIV; IsoId=P23634-1; Sequence=Displayed; Name=XA; Synonyms=AIICII; IsoId=P23634-2; Sequence=VSP_000405; Name=ZA; Synonyms=AICII; IsoId=P23634-3; Sequence=VSP_000402, VSP_000405; Name=XK; Synonyms=XG; IsoId=P23634-4; Sequence=VSP_000403, VSP_000405; Name=ZK; Synonyms=ZG; IsoId=P23634-5; Sequence=VSP_000402, VSP_000403, VSP_000405; Name=XB; Synonyms=AIICI, hPMCA4b; IsoId=P23634-6; Sequence=VSP_000404; Name=ZB; Synonyms=AICI; IsoId=P23634-7; Sequence=VSP_000402, VSP_000404; Name=ZD; Synonyms=AICIV; IsoId=P23634-8; Sequence=VSP_000402; 
# AltName	AT2B4_HUMAN	Matrix-remodeling-associated protein 1
# AltName	AT2B4_HUMAN	Plasma membrane calcium ATPase isoform 4
# AltName	AT2B4_HUMAN	Plasma membrane calcium pump isoform 4
# BioGrid	106983	49
# CATALYTIC ACTIVITY	ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2). {ECO:0000269|PubMed	8530416}. 
# CCDS	CCDS1440	-. [P23634-6]
# CCDS	CCDS30977	-. [P23634-2]
# ChiTaRS	ATP2B4	human
# ENZYME REGULATION	Activated by calcium/calmodulin. {ECO:0000269|PubMed	8530416}. 
# Ensembl	ENST00000341360	ENSP00000340930; ENSG00000058668. [P23634-2]
# Ensembl	ENST00000357681	ENSP00000350310; ENSG00000058668. [P23634-6]
# Ensembl	ENST00000367218	ENSP00000356187; ENSG00000058668. [P23634-2]
# ExpressionAtlas	P23634	baseline and differential
# FUNCTION	AT2B4_HUMAN	Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed 8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity). {ECO 0000250|UniProtKB Q6Q477, ECO 0000269|PubMed 8530416}. 
# GO_component	GO:0005886	plasma membrane; IDA:HPA.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0005901	caveola; TAS:BHF-UCL.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:Ensembl.
# GO_component	GO:0030018	Z disc; IDA:BHF-UCL.
# GO_component	GO:0030315	T-tubule; IDA:BHF-UCL.
# GO_component	GO:0036126	sperm flagellum; ISS:UniProtKB.
# GO_component	GO:0043005	neuron projection; IEA:Ensembl.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IBA:GO_Central.
# GO_component	GO:0043234	protein complex; ISS:BHF-UCL.
# GO_component	GO:0097228	sperm principal piece; IEA:Ensembl.
# GO_function	GO:0005388	calcium-transporting ATPase activity; IMP:BHF-UCL.
# GO_function	GO:0005516	calmodulin binding; IDA:BHF-UCL.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0030165	PDZ domain binding; IBA:GO_Central.
# GO_function	GO:0030346	protein phosphatase 2B binding; IDA:BHF-UCL.
# GO_function	GO:0036487	nitric-oxide synthase inhibitor activity; IDA:BHF-UCL.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_function	GO:0050998	nitric-oxide synthase binding; IPI:BHF-UCL.
# GO_function	GO:0097110	scaffold protein binding; ISS:BHF-UCL.
# GO_process	GO:0003407	neural retina development; IEA:Ensembl.
# GO_process	GO:0006357	regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.
# GO_process	GO:0006874	cellular calcium ion homeostasis; ISS:UniProtKB.
# GO_process	GO:0007283	spermatogenesis; IEA:Ensembl.
# GO_process	GO:0010751	negative regulation of nitric oxide mediated signal transduction; IDA:BHF-UCL.
# GO_process	GO:0021766	hippocampus development; IEA:Ensembl.
# GO_process	GO:0030317	flagellated sperm motility; ISS:UniProtKB.
# GO_process	GO:0033138	positive regulation of peptidyl-serine phosphorylation; IDA:BHF-UCL.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0045019	negative regulation of nitric oxide biosynthetic process; IDA:BHF-UCL.
# GO_process	GO:0051001	negative regulation of nitric-oxide synthase activity; IDA:BHF-UCL.
# GO_process	GO:0051599	response to hydrostatic pressure; IMP:BHF-UCL.
# GO_process	GO:0070588	calcium ion transmembrane transport; IMP:BHF-UCL.
# GO_process	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade; IDA:BHF-UCL.
# GO_process	GO:0071872	cellular response to epinephrine stimulus; IDA:BHF-UCL.
# GO_process	GO:0097553	calcium ion transmembrane import into cytosol; IC:BHF-UCL.
# GO_process	GO:0098703	calcium ion import across plasma membrane; IC:BHF-UCL.
# GO_process	GO:0098736	negative regulation of the force of heart contraction; IDA:BHF-UCL.
# GO_process	GO:1900082	negative regulation of arginine catabolic process; IDA:BHF-UCL.
# GO_process	GO:1901205	negative regulation of adrenergic receptor signaling pathway involved in heart process; IDA:BHF-UCL.
# GO_process	GO:1901660	calcium ion export; IEA:Ensembl.
# GO_process	GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation; NAS:BHF-UCL.
# GO_process	GO:1902305	regulation of sodium ion transmembrane transport; IC:BHF-UCL.
# GO_process	GO:1902806	regulation of cell cycle G1/S phase transition; IMP:CACAO.
# GO_process	GO:1903243	negative regulation of cardiac muscle hypertrophy in response to stress; IMP:BHF-UCL.
# GO_process	GO:1903249	negative regulation of citrulline biosynthetic process; IDA:BHF-UCL.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GO_process	GO:2000481	positive regulation of cAMP-dependent protein kinase activity; IDA:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0005929	cilium
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0030234	enzyme regulator activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0048870	cell motility
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.1110.10	-; 3.
# Genevisible	P23634	HS
# HGNC	HGNC:817	ATP2B4
# INTERACTION	AT2B4_HUMAN	P01258 CALCA; NbExp=2; IntAct=EBI-1174388, EBI-1018474; Q63622 Dlg2 (xeno); NbExp=2; IntAct=EBI-1174437, EBI-396947; Q62936 Dlg3 (xeno); NbExp=2; IntAct=EBI-1174437, EBI-349596; 
# IntAct	P23634	22
# InterPro	IPR001757	P_typ_ATPase
# InterPro	IPR004014	ATPase_P-typ_cation-transptr_N
# InterPro	IPR006068	ATPase_P-typ_cation-transptr_C
# InterPro	IPR006408	P-type_ATPase_IIB
# InterPro	IPR008250	ATPase_P-typ_transduc_dom_A
# InterPro	IPR018303	ATPase_P-typ_P_site
# InterPro	IPR022141	ATP_Ca_trans_C
# InterPro	IPR023214	HAD-like_dom
# InterPro	IPR023298	ATPase_P-typ_TM_dom
# InterPro	IPR023299	ATPase_P-typ_cyto_domN
# InterPro	IPR030319	ATP2B1/4
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04970	Salivary secretion
# KEGG_Pathway	ko04972	Pancreatic secretion
# MIM	108732	gene
# Organism	AT2B4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR24093:SF276	PTHR24093:SF276; 2
# PDB	1CFF	NMR; -; B=1086-1104
# PDB	2KNE	NMR; -; B=1086-1149
# PIR	A35547	A35547
# PROSITE	PS00154	ATPASE_E1_E2
# Pfam	PF00122	E1-E2_ATPase; 2
# Pfam	PF00689	Cation_ATPase_C
# Pfam	PF00690	Cation_ATPase_N
# Pfam	PF12424	ATP_Ca_trans_C; 2
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-418359	Reduction of cytosolic Ca++ levels
# Reactome	R-HSA-5578775	Ion homeostasis
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	Plasma membrane calcium-transporting ATPase 4 {ECO	0000305}
# RefSeq	NP_001001396	NM_001001396.2. [P23634-2]
# RefSeq	NP_001675	NM_001684.4. [P23634-6]
# SIMILARITY	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. {ECO	0000305}.
# SMART	SM00831	Cation_ATPase_N
# SUBCELLULAR LOCATION	AT2B4_HUMAN	Cell membrane {ECO 0000269|PubMed 2137451}; Multi-pass membrane protein {ECO 0000255}. Cell projection, cilium, flagellum membrane {ECO 0000250|UniProtKB Q6Q477}; Multi- pass membrane protein {ECO 0000255}. 
# SUBUNIT	AT2B4_HUMAN	Interacts with PDZD11 (PubMed 12763866). Interacts with SLC35G1 and STIM1 (PubMed 22084111). Interacts with calmodulin (PubMed 2963820, PubMed 10493800). {ECO 0000269|PubMed 10493800, ECO 0000269|PubMed 12763866, ECO 0000269|PubMed 22084111, ECO 0000269|PubMed 2963820}. 
# SUPFAM	SSF56784	SSF56784; 2
# SUPFAM	SSF81660	SSF81660
# TCDB	3.A.3.2	the p-type atpase (p-atpase) superfamily
# TIGRFAMs	TIGR01494	ATPase_P-type; 3
# TIGRFAMs	TIGR01517	ATPase-IIB_Ca
# TISSUE SPECIFICITY	Isoform XB is the most abundant isoform and is expressed ubiquitously. Isoforms containing segment Z have only been detected in heart, while isoforms containing segment a have been found in heart, stomach and brain cortex. {ECO:0000269|PubMed	1531651}. 
# UCSC	uc001gzv	human. [P23634-1]
# eggNOG	ENOG410XNNC	LUCA
# eggNOG	KOG0204	Eukaryota
BLAST	swissprot:AT2B4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AT2B4_HUMAN
BioCyc	ZFISH:HS00723-MONOMER	http://biocyc.org/getid?id=ZFISH:HS00723-MONOMER
COXPRESdb	493	http://coxpresdb.jp/data/gene/493.shtml
CleanEx	HS_ATP2B2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP2B2
CleanEx	HS_ATP2B4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP2B4
DIP	DIP-6128N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-6128N
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1007/BF00229314	http://dx.doi.org/10.1007/BF00229314
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/bi9908235	http://dx.doi.org/10.1021/bi9908235
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1073/pnas.1117231108	http://dx.doi.org/10.1073/pnas.1117231108
DOI	10.1073/pnas.85.9.2914	http://dx.doi.org/10.1073/pnas.85.9.2914
DOI	10.1074/jbc.270.50.30111	http://dx.doi.org/10.1074/jbc.270.50.30111
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1749-6632.2003.tb07230.x	http://dx.doi.org/10.1111/j.1749-6632.2003.tb07230.x
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EC_number	EC:3.6.3.8 {ECO:0000269|PubMed:8530416}	http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.8 {ECO:0000269|PubMed:8530416}
EMBL	AC114402	http://www.ebi.ac.uk/ena/data/view/AC114402
EMBL	AC114402	http://www.ebi.ac.uk/ena/data/view/AC114402
EMBL	AL513343	http://www.ebi.ac.uk/ena/data/view/AL513343
EMBL	AL513343	http://www.ebi.ac.uk/ena/data/view/AL513343
EMBL	BC140774	http://www.ebi.ac.uk/ena/data/view/BC140774
EMBL	BX537444	http://www.ebi.ac.uk/ena/data/view/BX537444
EMBL	CH471067	http://www.ebi.ac.uk/ena/data/view/CH471067
EMBL	CH471067	http://www.ebi.ac.uk/ena/data/view/CH471067
EMBL	M25874	http://www.ebi.ac.uk/ena/data/view/M25874
EMBL	M83363	http://www.ebi.ac.uk/ena/data/view/M83363
EMBL	U42026	http://www.ebi.ac.uk/ena/data/view/U42026
EMBL	U42061	http://www.ebi.ac.uk/ena/data/view/U42061
EMBL	U42062	http://www.ebi.ac.uk/ena/data/view/U42062
EMBL	U42378	http://www.ebi.ac.uk/ena/data/view/U42378
ENZYME	3.6.3.8 {ECO:0000269|PubMed:8530416}	http://enzyme.expasy.org/EC/3.6.3.8 {ECO:0000269|PubMed:8530416}
Ensembl	ENST00000341360	http://www.ensembl.org/id/ENST00000341360
Ensembl	ENST00000357681	http://www.ensembl.org/id/ENST00000357681
Ensembl	ENST00000367218	http://www.ensembl.org/id/ENST00000367218
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005901
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0030018	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030018
GO_component	GO:0030315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030315
GO_component	GO:0036126	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036126
GO_component	GO:0043005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043005
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GO_component	GO:0097228	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097228
GO_function	GO:0005388	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005388
GO_function	GO:0005516	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005516
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0030165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030165
GO_function	GO:0030346	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030346
GO_function	GO:0036487	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036487
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_function	GO:0050998	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050998
GO_function	GO:0097110	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097110
GO_process	GO:0003407	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003407
GO_process	GO:0006357	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006357
GO_process	GO:0006874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874
GO_process	GO:0007283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007283
GO_process	GO:0010751	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010751
GO_process	GO:0021766	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021766
GO_process	GO:0030317	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030317
GO_process	GO:0033138	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033138
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0045019	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045019
GO_process	GO:0051001	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051001
GO_process	GO:0051599	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051599
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:0070885	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070885
GO_process	GO:0071872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071872
GO_process	GO:0097553	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097553
GO_process	GO:0098703	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098703
GO_process	GO:0098736	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098736
GO_process	GO:1900082	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900082
GO_process	GO:1901205	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901205
GO_process	GO:1901660	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901660
GO_process	GO:1902083	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902083
GO_process	GO:1902305	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902305
GO_process	GO:1902806	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902806
GO_process	GO:1903243	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903243
GO_process	GO:1903249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903249
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GO_process	GO:2000481	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000481
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0005929	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005929
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0030234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.1110.10	http://www.cathdb.info/version/latest/superfamily/1.20.1110.10
GeneCards	ATP2B4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP2B4
GeneID	493	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=493
GeneTree	ENSGT00510000046331	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00510000046331
HGNC	HGNC:817	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:817
HOVERGEN	HBG061286	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG061286&db=HOVERGEN
HPA	CAB016118	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB016118
HPA	HPA040431	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA040431
InParanoid	P23634	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23634
IntAct	P23634	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23634*
IntEnz	3.6.3.8 {ECO:0000269|PubMed:8530416}	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.8 {ECO:0000269|PubMed:8530416}
InterPro	IPR001757	http://www.ebi.ac.uk/interpro/entry/IPR001757
InterPro	IPR004014	http://www.ebi.ac.uk/interpro/entry/IPR004014
InterPro	IPR006068	http://www.ebi.ac.uk/interpro/entry/IPR006068
InterPro	IPR006408	http://www.ebi.ac.uk/interpro/entry/IPR006408
InterPro	IPR008250	http://www.ebi.ac.uk/interpro/entry/IPR008250
InterPro	IPR018303	http://www.ebi.ac.uk/interpro/entry/IPR018303
InterPro	IPR022141	http://www.ebi.ac.uk/interpro/entry/IPR022141
InterPro	IPR023214	http://www.ebi.ac.uk/interpro/entry/IPR023214
InterPro	IPR023298	http://www.ebi.ac.uk/interpro/entry/IPR023298
InterPro	IPR023299	http://www.ebi.ac.uk/interpro/entry/IPR023299
InterPro	IPR030319	http://www.ebi.ac.uk/interpro/entry/IPR030319
Jabion	493	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=493
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:493	http://www.genome.jp/dbget-bin/www_bget?hsa:493
KEGG_Orthology	KO:K05850	http://www.genome.jp/dbget-bin/www_bget?KO:K05850
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04970	http://www.genome.jp/kegg-bin/show_pathway?ko04970
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
MIM	108732	http://www.ncbi.nlm.nih.gov/omim/108732
MINT	MINT-219327	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-219327
OMA	LNNNVFI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LNNNVFI
PANTHER	PTHR24093:SF276	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24093:SF276
PDB	1CFF	http://www.ebi.ac.uk/pdbe-srv/view/entry/1CFF
PDB	2KNE	http://www.ebi.ac.uk/pdbe-srv/view/entry/2KNE
PDBsum	1CFF	http://www.ebi.ac.uk/pdbsum/1CFF
PDBsum	2KNE	http://www.ebi.ac.uk/pdbsum/2KNE
PROSITE	PS00154	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00154
PSORT	swissprot:AT2B4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AT2B4_HUMAN
PSORT-B	swissprot:AT2B4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AT2B4_HUMAN
PSORT2	swissprot:AT2B4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AT2B4_HUMAN
Pfam	PF00122	http://pfam.xfam.org/family/PF00122
Pfam	PF00689	http://pfam.xfam.org/family/PF00689
Pfam	PF00690	http://pfam.xfam.org/family/PF00690
Pfam	PF12424	http://pfam.xfam.org/family/PF12424
PharmGKB	PA25110	http://www.pharmgkb.org/do/serve?objId=PA25110&objCls=Gene
Phobius	swissprot:AT2B4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AT2B4_HUMAN
PhylomeDB	P23634	http://phylomedb.org/?seqid=P23634
ProteinModelPortal	P23634	http://www.proteinmodelportal.org/query/uniprot/P23634
PubMed	10493800	http://www.ncbi.nlm.nih.gov/pubmed/10493800
PubMed	12763866	http://www.ncbi.nlm.nih.gov/pubmed/12763866
PubMed	1531651	http://www.ncbi.nlm.nih.gov/pubmed/1531651
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	2137451	http://www.ncbi.nlm.nih.gov/pubmed/2137451
PubMed	22084111	http://www.ncbi.nlm.nih.gov/pubmed/22084111
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	2963820	http://www.ncbi.nlm.nih.gov/pubmed/2963820
PubMed	2966397	http://www.ncbi.nlm.nih.gov/pubmed/2966397
PubMed	7989379	http://www.ncbi.nlm.nih.gov/pubmed/7989379
PubMed	8245032	http://www.ncbi.nlm.nih.gov/pubmed/8245032
PubMed	8530416	http://www.ncbi.nlm.nih.gov/pubmed/8530416
PubMed	8700162	http://www.ncbi.nlm.nih.gov/pubmed/8700162
Reactome	R-HSA-418359	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418359
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_001001396	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001001396
RefSeq	NP_001675	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001675
SMART	SM00831	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00831
SMR	P23634	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23634
STRING	9606.ENSP00000350310	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000350310&targetmode=cogs
SUPFAM	SSF56784	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784
SUPFAM	SSF81660	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81660
TCDB	3.A.3.2	http://www.tcdb.org/search/result.php?tc=3.A.3.2
TIGRFAMs	TIGR01494	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01494
TIGRFAMs	TIGR01517	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01517
UCSC	uc001gzv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001gzv&org=rat
UniGene	Hs.343522	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.343522
UniGene	Hs.733333	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.733333
UniProtKB	AT2B4_HUMAN	http://www.uniprot.org/uniprot/AT2B4_HUMAN
UniProtKB-AC	P23634	http://www.uniprot.org/uniprot/P23634
charge	swissprot:AT2B4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AT2B4_HUMAN
eggNOG	ENOG410XNNC	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNNC
eggNOG	KOG0204	http://eggnogapi.embl.de/nog_data/html/tree/KOG0204
epestfind	swissprot:AT2B4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AT2B4_HUMAN
garnier	swissprot:AT2B4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AT2B4_HUMAN
helixturnhelix	swissprot:AT2B4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AT2B4_HUMAN
hmoment	swissprot:AT2B4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AT2B4_HUMAN
iep	swissprot:AT2B4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AT2B4_HUMAN
inforesidue	swissprot:AT2B4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AT2B4_HUMAN
neXtProt	NX_P23634	http://www.nextprot.org/db/entry/NX_P23634
octanol	swissprot:AT2B4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AT2B4_HUMAN
pepcoil	swissprot:AT2B4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AT2B4_HUMAN
pepdigest	swissprot:AT2B4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AT2B4_HUMAN
pepinfo	swissprot:AT2B4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AT2B4_HUMAN
pepnet	swissprot:AT2B4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AT2B4_HUMAN
pepstats	swissprot:AT2B4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AT2B4_HUMAN
pepwheel	swissprot:AT2B4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AT2B4_HUMAN
pepwindow	swissprot:AT2B4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AT2B4_HUMAN
sigcleave	swissprot:AT2B4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AT2B4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	EAA2_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P43004-1; Sequence=Displayed; Name=2; IsoId=P43004-2; Sequence=VSP_037152; Name=3; Synonyms=EEAT2b; IsoId=P43004-3; Sequence=VSP_054934; 
# AltName	EAA2_HUMAN	Glutamate/aspartate transporter II
# AltName	EAA2_HUMAN	Sodium-dependent glutamate/aspartate transporter 2
# AltName	EAA2_HUMAN	Solute carrier family 1 member 2
# BioGrid	112397	10
# CCDS	CCDS31459	-. [P43004-1]
# CCDS	CCDS55756	-. [P43004-2]
# ChiTaRS	SLC1A2	human
# Ensembl	ENST00000278379	ENSP00000278379; ENSG00000110436. [P43004-1]
# Ensembl	ENST00000395750	ENSP00000379099; ENSG00000110436. [P43004-2]
# Ensembl	ENST00000395753	ENSP00000379102; ENSG00000110436. [P43004-2]
# Ensembl	ENST00000606205	ENSP00000476124; ENSG00000110436. [P43004-3]
# ExpressionAtlas	P43004	baseline and differential
# FUNCTION	EAA2_HUMAN	Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0009986	cell surface; IDA:UniProtKB.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0030673	axolemma; IEA:Ensembl.
# GO_function	EAA2_HUMAN	GO 0015501 glutamate sodium symporter activity; IEA Ensembl.
# GO_function	GO:0005313	L-glutamate transmembrane transporter activity; IDA:BHF-UCL.
# GO_function	GO:0005314	high-affinity glutamate transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:ProtInc.
# GO_process	GO:0007632	visual behavior; IEA:Ensembl.
# GO_process	GO:0009611	response to wounding; IEA:Ensembl.
# GO_process	GO:0010259	multicellular organism aging; IEA:Ensembl.
# GO_process	GO:0014047	glutamate secretion; TAS:Reactome.
# GO_process	GO:0021537	telencephalon development; IEA:Ensembl.
# GO_process	GO:0030534	adult behavior; IEA:Ensembl.
# GO_process	GO:0031668	cellular response to extracellular stimulus; IEA:Ensembl.
# GO_process	GO:0035264	multicellular organism growth; IEA:Ensembl.
# GO_process	GO:0042493	response to drug; IEA:Ensembl.
# GO_process	GO:0043200	response to amino acid; IEA:Ensembl.
# GO_process	GO:0046326	positive regulation of glucose import; IEA:Ensembl.
# GO_process	GO:0051938	L-glutamate import; IDA:UniProtKB.
# GO_process	GO:0070779	D-aspartate import; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0007568	aging
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0040007	growth
# GOslim_process	GO:0048856	anatomical structure development
# Gene3D	1.10.3860.10	-; 2.
# Genevisible	P43004	HS
# HGNC	HGNC:10940	SLC1A2
# INTERACTION	EAA2_HUMAN	P10636 MAPT; NbExp=4; IntAct=EBI-3440986, EBI-366182; 
# IntAct	P43004	2
# InterPro	IPR001991	Na-dicarboxylate_symporter
# InterPro	IPR018107	Na-dicarboxylate_symporter_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04724	Glutamatergic synapse
# KEGG_Pathway	ko05014	Amyotrophic lateral sclerosis (ALS)
# MIM	600300	gene
# Organism	EAA2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11958	PTHR11958; 2
# PIR	I37426	I37426
# PIR	I38432	I38432
# PRINTS	PR00173	EDTRNSPORT
# PROSITE	PS00713	NA_DICARBOXYL_SYMP_1
# PROSITE	PS00714	NA_DICARBOXYL_SYMP_2
# PTM	EAA2_HUMAN	Glycosylated. 
# PTM	EAA2_HUMAN	Palmitoylation at Cys-38 is not required for correct subcellular localization, but is important for glutamate uptake activity. {ECO 0000250}. 
# Pfam	PF00375	SDF
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-210455	Astrocytic Glutamate-Glutamine Uptake And Metabolism
# Reactome	R-HSA-210500	Glutamate Neurotransmitter Release Cycle
# Reactome	R-HSA-425393	Transport of inorganic cations/anions and amino acids/oligopeptides
# RecName	EAA2_HUMAN	Excitatory amino acid transporter 2
# RefSeq	NP_001182657	NM_001195728.2. [P43004-2]
# RefSeq	NP_001239581	NM_001252652.1. [P43004-2]
# RefSeq	NP_004162	NM_004171.3. [P43004-1]
# SIMILARITY	Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A2 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	EAA2_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Homotrimer. Isoform 3 can oligomerize with isoform 1. Interacts with AJUBA (By similarity). {ECO	0000250}. 
# SUPFAM	SSF118215	SSF118215; 2
# TCDB	2.A.23.2:the dicarboxylate/amino acid	cation (na(+) or h(+)) symporter (daacs) family
# UCSC	uc001mwd	human. [P43004-1]
# eggNOG	COG1301	LUCA
# eggNOG	KOG3787	Eukaryota
BLAST	swissprot:EAA2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:EAA2_HUMAN
BioCyc	ZFISH:ENSG00000110436-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000110436-MONOMER
COXPRESdb	6506	http://coxpresdb.jp/data/gene/6506.shtml
CleanEx	HS_SLC1A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC1A2
DOI	10.1016/0005-2736(94)90026-4	http://dx.doi.org/10.1016/0005-2736(94)90026-4
DOI	10.1016/0005-2736(94)90192-9	http://dx.doi.org/10.1016/0005-2736(94)90192-9
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1046/j.1471-4159.2003.01958.x	http://dx.doi.org/10.1046/j.1471-4159.2003.01958.x
DOI	10.1074/jbc.M110.153494	http://dx.doi.org/10.1074/jbc.M110.153494
DOI	10.1074/jbc.M408038200	http://dx.doi.org/10.1074/jbc.M408038200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC090625	http://www.ebi.ac.uk/ena/data/view/AC090625
EMBL	AK298769	http://www.ebi.ac.uk/ena/data/view/AK298769
EMBL	AL133330	http://www.ebi.ac.uk/ena/data/view/AL133330
EMBL	AY066021	http://www.ebi.ac.uk/ena/data/view/AY066021
EMBL	BC132768	http://www.ebi.ac.uk/ena/data/view/BC132768
EMBL	CH471064	http://www.ebi.ac.uk/ena/data/view/CH471064
EMBL	D85884	http://www.ebi.ac.uk/ena/data/view/D85884
EMBL	U01824	http://www.ebi.ac.uk/ena/data/view/U01824
EMBL	U03505	http://www.ebi.ac.uk/ena/data/view/U03505
EMBL	Z32517	http://www.ebi.ac.uk/ena/data/view/Z32517
Ensembl	ENST00000278379	http://www.ensembl.org/id/ENST00000278379
Ensembl	ENST00000395750	http://www.ensembl.org/id/ENST00000395750
Ensembl	ENST00000395753	http://www.ensembl.org/id/ENST00000395753
Ensembl	ENST00000606205	http://www.ensembl.org/id/ENST00000606205
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030673	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030673
GO_function	GO:0005313	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005313
GO_function	GO:0005314	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005314
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_function	GO:0015501	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015501
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007632	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007632
GO_process	GO:0009611	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009611
GO_process	GO:0010259	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010259
GO_process	GO:0014047	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014047
GO_process	GO:0021537	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021537
GO_process	GO:0030534	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030534
GO_process	GO:0031668	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031668
GO_process	GO:0035264	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035264
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0043200	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043200
GO_process	GO:0046326	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046326
GO_process	GO:0051938	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051938
GO_process	GO:0070779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070779
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0007568	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007568
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0040007	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040007
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
Gene3D	1.10.3860.10	http://www.cathdb.info/version/latest/superfamily/1.10.3860.10
GeneCards	SLC1A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC1A2
GeneID	6506	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6506
GeneTree	ENSGT00760000119117	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119117
HGNC	HGNC:10940	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10940
HOVERGEN	HBG000080	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000080&db=HOVERGEN
HPA	CAB002574	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB002574
HPA	HPA009172	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA009172
InParanoid	P43004	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P43004
IntAct	P43004	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P43004*
InterPro	IPR001991	http://www.ebi.ac.uk/interpro/entry/IPR001991
InterPro	IPR018107	http://www.ebi.ac.uk/interpro/entry/IPR018107
Jabion	6506	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6506
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6506	http://www.genome.jp/dbget-bin/www_bget?hsa:6506
KEGG_Orthology	KO:K05613	http://www.genome.jp/dbget-bin/www_bget?KO:K05613
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
KEGG_Pathway	ko05014	http://www.genome.jp/kegg-bin/show_pathway?ko05014
MIM	600300	http://www.ncbi.nlm.nih.gov/omim/600300
OMA	IKMERLG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IKMERLG
OrthoDB	EOG091G0UCE	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0UCE
PANTHER	PTHR11958	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11958
PRINTS	PR00173	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00173
PROSITE	PS00713	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00713
PROSITE	PS00714	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00714
PSORT	swissprot:EAA2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:EAA2_HUMAN
PSORT-B	swissprot:EAA2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:EAA2_HUMAN
PSORT2	swissprot:EAA2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:EAA2_HUMAN
Pfam	PF00375	http://pfam.xfam.org/family/PF00375
PharmGKB	PA35827	http://www.pharmgkb.org/do/serve?objId=PA35827&objCls=Gene
Phobius	swissprot:EAA2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:EAA2_HUMAN
PhylomeDB	P43004	http://phylomedb.org/?seqid=P43004
ProteinModelPortal	P43004	http://www.proteinmodelportal.org/query/uniprot/P43004
PubMed	12950454	http://www.ncbi.nlm.nih.gov/pubmed/12950454
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15265858	http://www.ncbi.nlm.nih.gov/pubmed/15265858
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	20688910	http://www.ncbi.nlm.nih.gov/pubmed/20688910
PubMed	7521911	http://www.ncbi.nlm.nih.gov/pubmed/7521911
PubMed	7522567	http://www.ncbi.nlm.nih.gov/pubmed/7522567
PubMed	8172925	http://www.ncbi.nlm.nih.gov/pubmed/8172925
PubMed	9463476	http://www.ncbi.nlm.nih.gov/pubmed/9463476
Reactome	R-HSA-210455	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-210455
Reactome	R-HSA-210500	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-210500
Reactome	R-HSA-425393	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425393
RefSeq	NP_001182657	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001182657
RefSeq	NP_001239581	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001239581
RefSeq	NP_004162	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004162
STRING	9606.ENSP00000278379	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000278379&targetmode=cogs
SUPFAM	SSF118215	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF118215
TCDB	2.A.23.2	http://www.tcdb.org/search/result.php?tc=2.A.23.2
UCSC	uc001mwd	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001mwd&org=rat
UniGene	Hs.502338	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.502338
UniGene	Hs.661429	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.661429
UniProtKB	EAA2_HUMAN	http://www.uniprot.org/uniprot/EAA2_HUMAN
UniProtKB-AC	P43004	http://www.uniprot.org/uniprot/P43004
charge	swissprot:EAA2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:EAA2_HUMAN
eggNOG	COG1301	http://eggnogapi.embl.de/nog_data/html/tree/COG1301
eggNOG	KOG3787	http://eggnogapi.embl.de/nog_data/html/tree/KOG3787
epestfind	swissprot:EAA2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:EAA2_HUMAN
garnier	swissprot:EAA2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:EAA2_HUMAN
helixturnhelix	swissprot:EAA2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:EAA2_HUMAN
hmoment	swissprot:EAA2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:EAA2_HUMAN
iep	swissprot:EAA2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:EAA2_HUMAN
inforesidue	swissprot:EAA2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:EAA2_HUMAN
neXtProt	NX_P43004	http://www.nextprot.org/db/entry/NX_P43004
octanol	swissprot:EAA2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:EAA2_HUMAN
pepcoil	swissprot:EAA2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:EAA2_HUMAN
pepdigest	swissprot:EAA2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:EAA2_HUMAN
pepinfo	swissprot:EAA2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:EAA2_HUMAN
pepnet	swissprot:EAA2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:EAA2_HUMAN
pepstats	swissprot:EAA2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:EAA2_HUMAN
pepwheel	swissprot:EAA2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:EAA2_HUMAN
pepwindow	swissprot:EAA2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:EAA2_HUMAN
sigcleave	swissprot:EAA2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:EAA2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S26A4_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O43511-1; Sequence=Displayed; Name=2; IsoId=O43511-2; Sequence=VSP_056688; Note=No experimental confirmation available.; 
# AltName	S26A4_HUMAN	Sodium-independent chloride/iodide transporter
# AltName	S26A4_HUMAN	Solute carrier family 26 member 4
# CCDS	CCDS5746	-. [O43511-1]
# ChiTaRS	SLC26A4	human
# DISEASE	S26A4_HUMAN	Deafness, autosomal recessive, 4 (DFNB4) [MIM 600791]  A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNB4 is associated with an enlarged vestibular aqueduct. {ECO 0000269|PubMed 10190331, ECO 0000269|PubMed 10700480, ECO 0000269|PubMed 11748854, ECO 0000269|PubMed 12676893, ECO 0000269|PubMed 14508505, ECO 0000269|PubMed 14679580, ECO 0000269|PubMed 19204907, ECO 0000269|PubMed 20108392, ECO 0000269|PubMed 20597900, ECO 0000269|PubMed 9500541}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	S26A4_HUMAN	Pendred syndrome (PDS) [MIM 274600]  An autosomal recessive disorder characterized by congenital sensorineural hearing loss in association with thyroid goiter. The disorder may account for up to 10% of the cases of hereditary deafness. The deafness is most often associated with a Mondini cochlear defect. Deafness occurs early, starting at birth or during the first years of life. It is bilateral, sometimes asymmetrical, fluctuant and often progressive. Thyroid perturbations, such as thyroid goiter and/or hypothyroidism appear most commonly during adolescence, but they can be congenital or appear later. {ECO 0000269|PubMed 10602116, ECO 0000269|PubMed 10718825, ECO 0000269|PubMed 10878664, ECO 0000269|PubMed 11317356, ECO 0000269|PubMed 11375792, ECO 0000269|PubMed 11748854, ECO 0000269|PubMed 11919333, ECO 0000269|PubMed 12788906, ECO 0000269|PubMed 12974744, ECO 0000269|PubMed 15355436, ECO 0000269|PubMed 15531480, ECO 0000269|PubMed 15689455, ECO 0000269|PubMed 19204907, ECO 0000269|PubMed 9398842, ECO 0000269|PubMed 9618166, ECO 0000269|PubMed 9618167}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000265715	ENSP00000265715; ENSG00000091137. [O43511-1]
# ExpressionAtlas	O43511	baseline and differential
# FUNCTION	S26A4_HUMAN	Sodium-independent transporter of chloride and iodide. {ECO 0000269|PubMed 10192399}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_component	GO:0031526	brush border membrane; ISS:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005254	chloride channel activity; IBA:GO_Central.
# GO_function	GO:0008271	secondary active sulfate transmembrane transporter activity; IEA:InterPro.
# GO_function	GO:0015106	bicarbonate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015108	chloride transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0015111	iodide transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015116	sulfate transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0019531	oxalate transmembrane transporter activity; IBA:GO_Central.
# GO_function	S26A4_HUMAN	GO 0015301 anion anion antiporter activity; IBA GO_Central.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006885	regulation of pH; ISS:UniProtKB.
# GO_process	GO:0007605	sensory perception of sound; TAS:ProtInc.
# GO_process	GO:0008272	sulfate transport; TAS:ProtInc.
# GO_process	GO:0015698	inorganic anion transport; TAS:ProtInc.
# GO_process	GO:0015701	bicarbonate transport; IBA:GO_Central.
# GO_process	GO:0032880	regulation of protein localization; ISS:UniProtKB.
# GO_process	GO:0042391	regulation of membrane potential; IBA:GO_Central.
# GO_process	GO:0051453	regulation of intracellular pH; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0050877	neurological system process
# Gene3D	3.30.750.24	-; 2.
# Genevisible	O43511	HS
# HGNC	HGNC:8818	SLC26A4
# InterPro	IPR001902	SLC26A/SulP_fam
# InterPro	IPR002645	STAS_dom
# InterPro	IPR011547	SLC26A/SulP_dom
# InterPro	IPR018045	S04_transporter_CS
# InterPro	IPR030285	Pendrin
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H00251	[Endocrine disease] Dyshormogenetic goiter
# KEGG_Disease	H00605	[Nervous system disease; Nervous system disease] Deafness, autosomal recessive
# MIM	274600	phenotype
# MIM	600791	phenotype
# MIM	605646	gene
# Organism	S26A4_HUMAN	Homo sapiens (Human)
# Orphanet	705	Pendred syndrome
# Orphanet	90636	Autosomal recessive non-syndromic sensorineural deafness type DFNB
# Orphanet	95713	Athyreosis
# Orphanet	95720	Thyroid hypoplasia
# PANTHER	PTHR11814	PTHR11814; 2
# PANTHER	PTHR11814:SF33	PTHR11814:SF33; 2
# PROSITE	PS01130	SLC26A
# PROSITE	PS50801	STAS
# Pfam	PF00916	Sulfate_transp
# Pfam	PF01740	STAS
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-427601	Multifunctional anion exchangers
# RecName	S26A4_HUMAN	Pendrin
# RefSeq	NP_000432	NM_000441.1. [O43511-1]
# RefSeq	XP_005250482	XM_005250425.2. [O43511-1]
# SIMILARITY	Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. {ECO	0000305}. 
# SIMILARITY	Contains 1 STAS domain. {ECO:0000255|PROSITE- ProRule	PRU00198}. 
# SUBCELLULAR LOCATION	S26A4_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. Cell membrane; Multi-pass membrane protein. Note=Localizes to the apical brush border of cells in the cortical collecting ducts of the kidney. {ECO 0000250}. 
# SUPFAM	SSF52091	SSF52091; 2
# TCDB	2.A.53.2.17	the sulfate permease (sulp) family
# TIGRFAMs	TIGR00815	sulP
# TISSUE SPECIFICITY	S26A4_HUMAN	High expression in adult thyroid, lower expression in adult and fetal kidney and fetal brain. Not expressed in other tissues. 
# UCSC	uc003vep	human. [O43511-1]
# WEB RESOURCE	S26A4_HUMAN	Name=Hereditary hearing loss homepage; Note=Gene page; URL="http //hereditaryhearingloss.org/main.aspx?c=.HHH&n=86162"; 
# WEB RESOURCE	S26A4_HUMAN	Name=Protein Spotlight; Note=A missing sense - Issue 133 of November 2011; URL="http //web.expasy.org/spotlight/back_issues/133";
# WEB RESOURCE	S26A4_HUMAN	Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http //shmpd.bii.a-star.edu.sg/gene.php?genestart=S&genename=SLC26A4+%40+PDS"; 
# WEB RESOURCE	S26A4_HUMAN	Name=Wikipedia; Note=Pendrin entry; URL="https //en.wikipedia.org/wiki/Pendrin"; 
# eggNOG	COG0659	LUCA
# eggNOG	KOG0236	Eukaryota
BLAST	swissprot:S26A4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S26A4_HUMAN
BioCyc	ZFISH:ENSG00000091137-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000091137-MONOMER
COXPRESdb	5172	http://coxpresdb.jp/data/gene/5172.shtml
CleanEx	HS_SLC26A4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC26A4
DOI	10.1002/(SICI)1096-8628(20000103)90:1<38::AID-AJMG8>3.3.CO	http://dx.doi.org/10.1002/(SICI)1096-8628(20000103)90:1<38::AID-AJMG8>3.3.CO
DOI	10.1002/ajmg.a.20272	http://dx.doi.org/10.1002/ajmg.a.20272
DOI	10.1002/humu.1116	http://dx.doi.org/10.1002/humu.1116
DOI	10.1002/humu.1238	http://dx.doi.org/10.1002/humu.1238
DOI	10.1002/humu.20884	http://dx.doi.org/10.1002/humu.20884
DOI	10.1002/humu.9043	http://dx.doi.org/10.1002/humu.9043
DOI	10.1007/s004390050933	http://dx.doi.org/10.1007/s004390050933
DOI	10.1034/j.1399-0004.2003.00144.x	http://dx.doi.org/10.1034/j.1399-0004.2003.00144.x
DOI	10.1038/7783	http://dx.doi.org/10.1038/7783
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1038/nature19057	http://dx.doi.org/10.1038/nature19057
DOI	10.1038/ng0398-215	http://dx.doi.org/10.1038/ng0398-215
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/ng1297-411	http://dx.doi.org/10.1038/ng1297-411
DOI	10.1038/sj.ejhg.5200489	http://dx.doi.org/10.1038/sj.ejhg.5200489
DOI	10.1038/sj.ejhg.5201073	http://dx.doi.org/10.1038/sj.ejhg.5201073
DOI	10.1046/j.1365-2265.2000.00930.x	http://dx.doi.org/10.1046/j.1365-2265.2000.00930.x
DOI	10.1093/hmg/7.7.1099	http://dx.doi.org/10.1093/hmg/7.7.1099
DOI	10.1093/hmg/7.7.1105	http://dx.doi.org/10.1093/hmg/7.7.1105
DOI	10.1093/qjmed/93.2.99	http://dx.doi.org/10.1093/qjmed/93.2.99
DOI	10.1097/01.mlg.0000244389.68568.a7	http://dx.doi.org/10.1097/01.mlg.0000244389.68568.a7
DOI	10.1111/j.1399-0004.2004.00296.x	http://dx.doi.org/10.1111/j.1399-0004.2004.00296.x
DOI	10.1111/j.1469-1809.2010.00581.x	http://dx.doi.org/10.1111/j.1469-1809.2010.00581.x
DOI	10.1136/jmg.2004.024208	http://dx.doi.org/10.1136/jmg.2004.024208
DOI	10.1136/jmg.40.4.242	http://dx.doi.org/10.1136/jmg.40.4.242
DOI	10.1203/00006450-200204000-00013	http://dx.doi.org/10.1203/00006450-200204000-00013
DOI	10.1210/jc.2002-021334	http://dx.doi.org/10.1210/jc.2002-021334
DOI	10.1210/jc.2004-1013	http://dx.doi.org/10.1210/jc.2004-1013
DOI	10.1210/jc.2006-0142	http://dx.doi.org/10.1210/jc.2006-0142
DOI	10.1210/jc.87.4.1778	http://dx.doi.org/10.1210/jc.87.4.1778
DOI	10.1530/eje.0.1440585	http://dx.doi.org/10.1530/eje.0.1440585
EMBL	AC002467	http://www.ebi.ac.uk/ena/data/view/AC002467
EMBL	AC078937	http://www.ebi.ac.uk/ena/data/view/AC078937
EMBL	AF030880	http://www.ebi.ac.uk/ena/data/view/AF030880
EMBL	AK294388	http://www.ebi.ac.uk/ena/data/view/AK294388
Ensembl	ENST00000265715	http://www.ensembl.org/id/ENST00000265715
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0031526	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031526
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0008271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008271
GO_function	GO:0015106	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015106
GO_function	GO:0015108	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015108
GO_function	GO:0015111	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015111
GO_function	GO:0015116	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015116
GO_function	GO:0015301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015301
GO_function	GO:0019531	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019531
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006885	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006885
GO_process	GO:0007605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007605
GO_process	GO:0008272	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008272
GO_process	GO:0015698	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015698
GO_process	GO:0015701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015701
GO_process	GO:0032880	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032880
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
Gene3D	3.30.750.24	http://www.cathdb.info/version/latest/superfamily/3.30.750.24
GeneCards	SLC26A4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC26A4
GeneID	5172	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5172
GeneTree	ENSGT00760000119026	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119026
H-InvDB	HIX0006991	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0006991
HGNC	HGNC:8818	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:8818
HOGENOM	HOG000006546	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006546&db=HOGENOM6
HOVERGEN	HBG000639	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000639&db=HOVERGEN
HPA	HPA042860	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042860
InParanoid	O43511	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O43511
InterPro	IPR001902	http://www.ebi.ac.uk/interpro/entry/IPR001902
InterPro	IPR002645	http://www.ebi.ac.uk/interpro/entry/IPR002645
InterPro	IPR011547	http://www.ebi.ac.uk/interpro/entry/IPR011547
InterPro	IPR018045	http://www.ebi.ac.uk/interpro/entry/IPR018045
InterPro	IPR030285	http://www.ebi.ac.uk/interpro/entry/IPR030285
Jabion	5172	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=5172
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00251	http://www.genome.jp/dbget-bin/www_bget?H00251
KEGG_Disease	H00605	http://www.genome.jp/dbget-bin/www_bget?H00605
KEGG_Gene	hsa:5172	http://www.genome.jp/dbget-bin/www_bget?hsa:5172
KEGG_Orthology	KO:K14702	http://www.genome.jp/dbget-bin/www_bget?KO:K14702
MIM	274600	http://www.ncbi.nlm.nih.gov/omim/274600
MIM	600791	http://www.ncbi.nlm.nih.gov/omim/600791
MIM	605646	http://www.ncbi.nlm.nih.gov/omim/605646
OMA	PSWNGLG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PSWNGLG
Orphanet	705	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=705
Orphanet	90636	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=90636
Orphanet	95713	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=95713
Orphanet	95720	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=95720
OrthoDB	EOG091G07RT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07RT
PANTHER	PTHR11814	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11814
PANTHER	PTHR11814:SF33	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11814:SF33
PROSITE	PS01130	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01130
PROSITE	PS50801	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50801
PSORT	swissprot:S26A4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S26A4_HUMAN
PSORT-B	swissprot:S26A4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S26A4_HUMAN
PSORT2	swissprot:S26A4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S26A4_HUMAN
Pfam	PF00916	http://pfam.xfam.org/family/PF00916
Pfam	PF01740	http://pfam.xfam.org/family/PF01740
PharmGKB	PA35506	http://www.pharmgkb.org/do/serve?objId=PA35506&objCls=Gene
Phobius	swissprot:S26A4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S26A4_HUMAN
PhylomeDB	O43511	http://phylomedb.org/?seqid=O43511
ProteinModelPortal	O43511	http://www.proteinmodelportal.org/query/uniprot/O43511
PubMed	10190331	http://www.ncbi.nlm.nih.gov/pubmed/10190331
PubMed	10192399	http://www.ncbi.nlm.nih.gov/pubmed/10192399
PubMed	10602116	http://www.ncbi.nlm.nih.gov/pubmed/10602116
PubMed	10700480	http://www.ncbi.nlm.nih.gov/pubmed/10700480
PubMed	10718825	http://www.ncbi.nlm.nih.gov/pubmed/10718825
PubMed	10878664	http://www.ncbi.nlm.nih.gov/pubmed/10878664
PubMed	11317356	http://www.ncbi.nlm.nih.gov/pubmed/11317356
PubMed	11375792	http://www.ncbi.nlm.nih.gov/pubmed/11375792
PubMed	11748854	http://www.ncbi.nlm.nih.gov/pubmed/11748854
PubMed	11919333	http://www.ncbi.nlm.nih.gov/pubmed/11919333
PubMed	11932316	http://www.ncbi.nlm.nih.gov/pubmed/11932316
PubMed	12112665	http://www.ncbi.nlm.nih.gov/pubmed/12112665
PubMed	12676893	http://www.ncbi.nlm.nih.gov/pubmed/12676893
PubMed	12788906	http://www.ncbi.nlm.nih.gov/pubmed/12788906
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	12974744	http://www.ncbi.nlm.nih.gov/pubmed/12974744
PubMed	14508505	http://www.ncbi.nlm.nih.gov/pubmed/14508505
PubMed	14679580	http://www.ncbi.nlm.nih.gov/pubmed/14679580
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15355436	http://www.ncbi.nlm.nih.gov/pubmed/15355436
PubMed	15531480	http://www.ncbi.nlm.nih.gov/pubmed/15531480
PubMed	15689455	http://www.ncbi.nlm.nih.gov/pubmed/15689455
PubMed	16684826	http://www.ncbi.nlm.nih.gov/pubmed/16684826
PubMed	17146393	http://www.ncbi.nlm.nih.gov/pubmed/17146393
PubMed	19204907	http://www.ncbi.nlm.nih.gov/pubmed/19204907
PubMed	20108392	http://www.ncbi.nlm.nih.gov/pubmed/20108392
PubMed	20597900	http://www.ncbi.nlm.nih.gov/pubmed/20597900
PubMed	27535533	http://www.ncbi.nlm.nih.gov/pubmed/27535533
PubMed	9398842	http://www.ncbi.nlm.nih.gov/pubmed/9398842
PubMed	9500541	http://www.ncbi.nlm.nih.gov/pubmed/9500541
PubMed	9618166	http://www.ncbi.nlm.nih.gov/pubmed/9618166
PubMed	9618167	http://www.ncbi.nlm.nih.gov/pubmed/9618167
Reactome	R-HSA-427601	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-427601
RefSeq	NP_000432	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000432
RefSeq	XP_005250482	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005250482
STRING	9606.ENSP00000265715	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000265715&targetmode=cogs
SUPFAM	SSF52091	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52091
TCDB	2.A.53.2.17	http://www.tcdb.org/search/result.php?tc=2.A.53.2.17
TIGRFAMs	TIGR00815	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00815
UCSC	uc003vep	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003vep&org=rat
UniGene	Hs.571246	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.571246
UniProtKB	S26A4_HUMAN	http://www.uniprot.org/uniprot/S26A4_HUMAN
UniProtKB-AC	O43511	http://www.uniprot.org/uniprot/O43511
charge	swissprot:S26A4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S26A4_HUMAN
eggNOG	COG0659	http://eggnogapi.embl.de/nog_data/html/tree/COG0659
eggNOG	KOG0236	http://eggnogapi.embl.de/nog_data/html/tree/KOG0236
epestfind	swissprot:S26A4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S26A4_HUMAN
garnier	swissprot:S26A4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S26A4_HUMAN
helixturnhelix	swissprot:S26A4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S26A4_HUMAN
hmoment	swissprot:S26A4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S26A4_HUMAN
iep	swissprot:S26A4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S26A4_HUMAN
inforesidue	swissprot:S26A4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S26A4_HUMAN
neXtProt	NX_O43511	http://www.nextprot.org/db/entry/NX_O43511
octanol	swissprot:S26A4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S26A4_HUMAN
pepcoil	swissprot:S26A4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S26A4_HUMAN
pepdigest	swissprot:S26A4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S26A4_HUMAN
pepinfo	swissprot:S26A4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S26A4_HUMAN
pepnet	swissprot:S26A4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S26A4_HUMAN
pepstats	swissprot:S26A4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S26A4_HUMAN
pepwheel	swissprot:S26A4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S26A4_HUMAN
pepwindow	swissprot:S26A4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S26A4_HUMAN
sigcleave	swissprot:S26A4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S26A4_HUMAN
## Database	ID	URL or Descriptions
# AltName	TRPM7_HUMAN	Channel-kinase 1
# AltName	TRPM7_HUMAN	Long transient receptor potential channel 7
# BioGrid	120177	23
# CATALYTIC ACTIVITY	TRPM7_HUMAN	ATP + a protein = ADP + a phosphoprotein. 
# COFACTOR	TRPM7_HUMAN	Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000250}; Note=Binds 1 zinc ion per subunit. {ECO 0000250}; 
# ChiTaRS	TRPM7	human
# DISEASE	TRPM7_HUMAN	Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (ALS-PDC1) [MIM 105500]  A neurodegenerative disorder characterized by chronic, progressive and uniformly fatal amyotrophic lateral sclerosis and parkinsonism-dementia. Both diseases are known to occur in the same kindred, the same sibship and even the same individual. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# Ensembl	ENST00000313478	ENSP00000320239; ENSG00000092439
# ExpressionAtlas	Q96QT4	baseline and differential
# FUNCTION	TRPM7_HUMAN	Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF- induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1). {ECO 0000269|PubMed 12887921, ECO 0000269|PubMed 15485879, ECO 0000269|PubMed 24316671}. 
# GO_component	GO:0001726	ruffle; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0004674	protein serine/threonine kinase activity; IEA:UniProtKB-KW.
# GO_function	GO:0005262	calcium channel activity; TAS:Reactome.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0010961	cellular magnesium ion homeostasis; IEA:InterPro.
# GO_process	GO:0016340	calcium-dependent cell-matrix adhesion; IEA:Ensembl.
# GO_process	GO:0031032	actomyosin structure organization; IEA:Ensembl.
# GO_process	GO:0046777	protein autophosphorylation; IEA:Ensembl.
# GO_process	GO:0051262	protein tetramerization; IEA:InterPro.
# GO_process	GO:0070266	necroptotic process; IMP:UniProtKB.
# GO_process	GO:0070588	calcium ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0016301	kinase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0007010	cytoskeleton organization
# GOslim_process	GO:0007155	cell adhesion
# GOslim_process	GO:0008219	cell death
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q96QT4	HS
# HGNC	HGNC:17994	TRPM7
# IntAct	Q96QT4	4
# InterPro	IPR004166	MHCK_EF2_kinase
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR011009	Kinase-like_dom
# InterPro	IPR029601	TRPM7
# InterPro	IPR032415	TRPM_tetra
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Brite	ko01001	 Protein kinases
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04978	Mineral absorption
# MIM	105500	phenotype
# MIM	605692	gene
# Organism	TRPM7_HUMAN	Homo sapiens (Human)
# Orphanet	90020	Amyotrophic lateral sclerosis-parkinsonism-dementia complex
# PANTHER	PTHR13800:SF8	PTHR13800:SF8; 3
# PROSITE	PS51158	ALPHA_KINASE
# PTM	TRPM7_HUMAN	Autophosphorylated. {ECO 0000250}. 
# Pfam	PF00520	Ion_trans
# Pfam	PF02816	Alpha_kinase
# Pfam	PF16519	TRPM_tetra
# Proteomes	UP000005640	Chromosome 15
# Reactome	R-HSA-3295583	TRP channels
# RecName	TRPM7_HUMAN	Transient receptor potential cation channel subfamily M member 7
# RefSeq	NP_001288141	NM_001301212.1
# RefSeq	NP_060142	NM_017672.5
# SEQUENCE CAUTION	Sequence=BAC11462.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD18773.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Contains 1 alpha-type protein kinase domain. {ECO:0000255|PROSITE-ProRule	PRU00501}. 
# SIMILARITY	In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. {ECO	0000305}. 
# SIMILARITY	In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM7 sub-subfamily. {ECO	0000305}. 
# SMART	SM00811	Alpha_kinase
# SUBCELLULAR LOCATION	TRPM7_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUBUNIT	Homodimer. Interacts with PLCB1 (By similarity). Forms heterodimers with TRPM6. {ECO:0000250, ECO	0000269|PubMed:14976260}. 
# SUPFAM	SSF56112	SSF56112
# TCDB	1.A.4.5	the transient receptor potential ca(2+) channel (trp-cc) family
# UCSC	uc001zyt	human
# eggNOG	ENOG410XR5B	LUCA
# eggNOG	KOG3614	Eukaryota
BLAST	swissprot:TRPM7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TRPM7_HUMAN
BioCyc	ZFISH:HS01771-MONOMER	http://biocyc.org/getid?id=ZFISH:HS01771-MONOMER
COXPRESdb	54822	http://coxpresdb.jp/data/gene/54822.shtml
CleanEx	HS_TRPM7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TRPM7
DOI	10.1016/S0092-8674(03)00556-7	http://dx.doi.org/10.1016/S0092-8674(03)00556-7
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/35079092	http://dx.doi.org/10.1038/35079092
DOI	10.1038/nature05610	http://dx.doi.org/10.1038/nature05610
DOI	10.1038/ncb2883	http://dx.doi.org/10.1038/ncb2883
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0305252101	http://dx.doi.org/10.1073/pnas.0305252101
DOI	10.1073/pnas.0505149102	http://dx.doi.org/10.1073/pnas.0505149102
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/jbc.C400441200	http://dx.doi.org/10.1074/jbc.C400441200
DOI	10.1074/jbc.M308820200	http://dx.doi.org/10.1074/jbc.M308820200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
EC_number	EC:2.7.11.1	http://www.genome.jp/dbget-bin/www_bget?EC:2.7.11.1
EMBL	AF346629	http://www.ebi.ac.uk/ena/data/view/AF346629
EMBL	AK000124	http://www.ebi.ac.uk/ena/data/view/AK000124
EMBL	AK075193	http://www.ebi.ac.uk/ena/data/view/AK075193
EMBL	AK172800	http://www.ebi.ac.uk/ena/data/view/AK172800
EMBL	AY032950	http://www.ebi.ac.uk/ena/data/view/AY032950
EMBL	BC051024	http://www.ebi.ac.uk/ena/data/view/BC051024
ENZYME	2.7.11.1	http://enzyme.expasy.org/EC/2.7.11.1
Ensembl	ENST00000313478	http://www.ensembl.org/id/ENST00000313478
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0001726	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001726
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0004674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004674
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0010961	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010961
GO_process	GO:0016340	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016340
GO_process	GO:0031032	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031032
GO_process	GO:0046777	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046777
GO_process	GO:0051262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051262
GO_process	GO:0070266	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070266
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0016301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0007010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007010
GOslim_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GOslim_process	GO:0008219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	TRPM7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TRPM7
GeneID	54822	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54822
GeneTree	ENSGT00760000119127	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119127
HGNC	HGNC:17994	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17994
HOGENOM	HOG000230920	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230920&db=HOGENOM6
HOVERGEN	HBG055663	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG055663&db=HOVERGEN
HPA	HPA035523	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035523
HPA	HPA052173	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA052173
InParanoid	Q96QT4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96QT4
IntAct	Q96QT4	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96QT4*
IntEnz	2.7.11.1	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.11.1
InterPro	IPR004166	http://www.ebi.ac.uk/interpro/entry/IPR004166
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR011009	http://www.ebi.ac.uk/interpro/entry/IPR011009
InterPro	IPR029601	http://www.ebi.ac.uk/interpro/entry/IPR029601
InterPro	IPR032415	http://www.ebi.ac.uk/interpro/entry/IPR032415
Jabion	54822	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=54822
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Brite	ko01001	http://www.genome.jp/dbget-bin/www_bget?ko01001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:54822	http://www.genome.jp/dbget-bin/www_bget?hsa:54822
KEGG_Orthology	KO:K04982	http://www.genome.jp/dbget-bin/www_bget?KO:K04982
KEGG_Pathway	ko04978	http://www.genome.jp/kegg-bin/show_pathway?ko04978
MIM	105500	http://www.ncbi.nlm.nih.gov/omim/105500
MIM	605692	http://www.ncbi.nlm.nih.gov/omim/605692
MINT	MINT-2815126	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-2815126
OMA	KQGPTNP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KQGPTNP
Orphanet	90020	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=90020
OrthoDB	EOG091G0DHL	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0DHL
PANTHER	PTHR13800:SF8	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13800:SF8
PROSITE	PS51158	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51158
PSORT	swissprot:TRPM7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TRPM7_HUMAN
PSORT-B	swissprot:TRPM7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TRPM7_HUMAN
PSORT2	swissprot:TRPM7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TRPM7_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF02816	http://pfam.xfam.org/family/PF02816
Pfam	PF16519	http://pfam.xfam.org/family/PF16519
PharmGKB	PA38273	http://www.pharmgkb.org/do/serve?objId=PA38273&objCls=Gene
Phobius	swissprot:TRPM7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TRPM7_HUMAN
PhylomeDB	Q96QT4	http://phylomedb.org/?seqid=Q96QT4
ProteinModelPortal	Q96QT4	http://www.proteinmodelportal.org/query/uniprot/Q96QT4
PubMed	11385574	http://www.ncbi.nlm.nih.gov/pubmed/11385574
PubMed	12887921	http://www.ncbi.nlm.nih.gov/pubmed/12887921
PubMed	14594813	http://www.ncbi.nlm.nih.gov/pubmed/14594813
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	14976260	http://www.ncbi.nlm.nih.gov/pubmed/14976260
PubMed	15485879	http://www.ncbi.nlm.nih.gov/pubmed/15485879
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16051700	http://www.ncbi.nlm.nih.gov/pubmed/16051700
PubMed	17344846	http://www.ncbi.nlm.nih.gov/pubmed/17344846
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24316671	http://www.ncbi.nlm.nih.gov/pubmed/24316671
Reactome	R-HSA-3295583	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3295583
RefSeq	NP_001288141	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001288141
RefSeq	NP_060142	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060142
SMART	SM00811	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00811
SMR	Q96QT4	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q96QT4
STRING	9606.ENSP00000320239	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000320239&targetmode=cogs
SUPFAM	SSF56112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56112
TCDB	1.A.4.5	http://www.tcdb.org/search/result.php?tc=1.A.4.5
UCSC	uc001zyt	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001zyt&org=rat
UniGene	Hs.512894	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.512894
UniProtKB	TRPM7_HUMAN	http://www.uniprot.org/uniprot/TRPM7_HUMAN
UniProtKB-AC	Q96QT4	http://www.uniprot.org/uniprot/Q96QT4
charge	swissprot:TRPM7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TRPM7_HUMAN
eggNOG	ENOG410XR5B	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XR5B
eggNOG	KOG3614	http://eggnogapi.embl.de/nog_data/html/tree/KOG3614
epestfind	swissprot:TRPM7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TRPM7_HUMAN
garnier	swissprot:TRPM7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TRPM7_HUMAN
helixturnhelix	swissprot:TRPM7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRPM7_HUMAN
hmoment	swissprot:TRPM7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TRPM7_HUMAN
iep	swissprot:TRPM7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TRPM7_HUMAN
inforesidue	swissprot:TRPM7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TRPM7_HUMAN
neXtProt	NX_Q96QT4	http://www.nextprot.org/db/entry/NX_Q96QT4
octanol	swissprot:TRPM7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TRPM7_HUMAN
pepcoil	swissprot:TRPM7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TRPM7_HUMAN
pepdigest	swissprot:TRPM7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TRPM7_HUMAN
pepinfo	swissprot:TRPM7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TRPM7_HUMAN
pepnet	swissprot:TRPM7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TRPM7_HUMAN
pepstats	swissprot:TRPM7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TRPM7_HUMAN
pepwheel	swissprot:TRPM7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TRPM7_HUMAN
pepwindow	swissprot:TRPM7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TRPM7_HUMAN
sigcleave	swissprot:TRPM7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TRPM7_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S35A2_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=UGT2; IsoId=P78381-1; Sequence=Displayed; Name=2; Synonyms=UGT1; IsoId=P78381-2; Sequence=VSP_003728; Name=3; IsoId=P78381-3; Sequence=VSP_042029; Name=4; IsoId=P78381-4; Sequence=VSP_054335, VSP_003728; Note=No experimental confirmation available.; Name=5; IsoId=P78381-5; Sequence=VSP_055197, VSP_003728; Note=No experimental confirmation available.; 
# AltName	S35A2_HUMAN	Solute carrier family 35 member A2
# AltName	S35A2_HUMAN	UDP-galactose transporter
# BioGrid	113202	5
# CCDS	CCDS14311	-. [P78381-1]
# CCDS	CCDS35247	-. [P78381-3]
# CCDS	CCDS43937	-. [P78381-2]
# CCDS	CCDS65253	-. [P78381-5]
# CCDS	CCDS65254	-. [P78381-4]
# ChiTaRS	SLC35A2	human
# DISEASE	S35A2_HUMAN	Congenital disorder of glycosylation 2M (CDG2M) [MIM 300896]  A disorder characterized by developmental delay, hypotonia, ocular anomalies, and brain malformations. Othere more variable clinical features included seizures, hypsarrhythmia, poor feeding, microcephaly, recurrent infections, dysmorphic features, shortened limbs, and coagulation defects. Congenital disorders of glycosylation are caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins and a wide variety of clinical features. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. {ECO 0000269|PubMed 23561849, ECO 0000269|PubMed 24115232}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000247138	ENSP00000247138; ENSG00000102100. [P78381-1]
# Ensembl	ENST00000376521	ENSP00000365704; ENSG00000102100. [P78381-2]
# Ensembl	ENST00000445167	ENSP00000402726; ENSG00000102100. [P78381-3]
# Ensembl	ENST00000452555	ENSP00000416002; ENSG00000102100. [P78381-4]
# Ensembl	ENST00000635285	ENSP00000489484; ENSG00000102100. [P78381-2]
# Ensembl	ENST00000635589	ENSP00000489197; ENSG00000102100. [P78381-5]
# ExpressionAtlas	P78381	baseline and differential
# FUNCTION	S35A2_HUMAN	Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function. 
# GO_component	GO:0000139	Golgi membrane; TAS:Reactome.
# GO_component	GO:0005634	nucleus; IDA:HPA.
# GO_component	GO:0005783	endoplasmic reticulum; IDA:CACAO.
# GO_component	GO:0005794	Golgi apparatus; IDA:CACAO.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005459	UDP-galactose transmembrane transporter activity; TAS:Reactome.
# GO_function	S35A2_HUMAN	GO 0005351 sugar proton symporter activity; IEA InterPro.
# GO_process	GO:0006012	galactose metabolic process; TAS:ProtInc.
# GO_process	GO:0015785	UDP-galactose transport; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0005975	carbohydrate metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0044281	small molecule metabolic process
# Genevisible	P78381	HS
# HGNC	HGNC:11022	SLC35A2
# INTERACTION	S35A2_HUMAN	Q9Y2D2 SLC35A3; NbExp=3; IntAct=EBI-8101118, EBI-3917581; 
# IntAct	P78381	5
# InterPro	IPR007271	Nuc_sug_transpt
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H00119	[Inherited metabolic disease] Congenital disorders of glycosylation (CDG) type II
# KEGG_Disease	H00606	[Congenital disorder; Epilepsy] Ohtahara syndrome
# MIM	300896	phenotype
# MIM	314375	gene
# Organism	S35A2_HUMAN	Homo sapiens (Human)
# Orphanet	356961	SLC35A2-CDG
# PANTHER	PTHR10231	PTHR10231
# PIR	JC5022	JC5022
# PIRSF	PIRSF005799	UDP-gal_transpt
# Pfam	PF04142	Nuc_sug_transp
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-727802	Transport of nucleotide sugars
# RecName	S35A2_HUMAN	UDP-galactose translocator
# RefSeq	NP_001027460	NM_001032289.2. [P78381-3]
# RefSeq	NP_001035963	NM_001042498.2. [P78381-2]
# RefSeq	NP_001269576	NM_001282647.1
# RefSeq	NP_001269577	NM_001282648.1
# RefSeq	NP_001269578	NM_001282649.1. [P78381-5]
# RefSeq	NP_001269579	NM_001282650.1
# RefSeq	NP_001269580	NM_001282651.1. [P78381-4]
# RefSeq	NP_005651	NM_005660.2. [P78381-1]
# SIMILARITY	Belongs to the nucleotide-sugar transporter family. SLC35A subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	S35A2_HUMAN	Golgi apparatus membrane; Multi-pass membrane protein. 
# SUBUNIT	Interacts with SLC35A3. {ECO:0000269|PubMed	23089177}. 
# TCDB	2.A.7.12	the drug/metabolite transporter (dmt) superfamily
# UCSC	uc004dlo	human. [P78381-1]
# eggNOG	COG0697	LUCA
# eggNOG	KOG2234	Eukaryota
BLAST	swissprot:S35A2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S35A2_HUMAN
BioCyc	ZFISH:ENSG00000102100-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000102100-MONOMER
COXPRESdb	7355	http://coxpresdb.jp/data/gene/7355.shtml
CleanEx	HS_SLC35A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC35A2
DOI	10.1002/humu.22446	http://dx.doi.org/10.1002/humu.22446
DOI	10.1007/BF01233383	http://dx.doi.org/10.1007/BF01233383
DOI	10.1016/j.ajhg.2013.03.012	http://dx.doi.org/10.1016/j.ajhg.2013.03.012
DOI	10.1016/j.febslet.2012.10.016	http://dx.doi.org/10.1016/j.febslet.2012.10.016
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/oxfordjournals.jbchem.a021404	http://dx.doi.org/10.1093/oxfordjournals.jbchem.a021404
DOI	10.1093/oxfordjournals.jbchem.a021523	http://dx.doi.org/10.1093/oxfordjournals.jbchem.a021523
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
EMBL	AB042425	http://www.ebi.ac.uk/ena/data/view/AB042425
EMBL	AB042425	http://www.ebi.ac.uk/ena/data/view/AB042425
EMBL	AF207550	http://www.ebi.ac.uk/ena/data/view/AF207550
EMBL	AK290284	http://www.ebi.ac.uk/ena/data/view/AK290284
EMBL	AK292816	http://www.ebi.ac.uk/ena/data/view/AK292816
EMBL	AK293415	http://www.ebi.ac.uk/ena/data/view/AK293415
EMBL	AK298484	http://www.ebi.ac.uk/ena/data/view/AK298484
EMBL	BC035747	http://www.ebi.ac.uk/ena/data/view/BC035747
EMBL	CH471224	http://www.ebi.ac.uk/ena/data/view/CH471224
EMBL	CH471224	http://www.ebi.ac.uk/ena/data/view/CH471224
EMBL	D84454	http://www.ebi.ac.uk/ena/data/view/D84454
EMBL	D88146	http://www.ebi.ac.uk/ena/data/view/D88146
Ensembl	ENST00000247138	http://www.ensembl.org/id/ENST00000247138
Ensembl	ENST00000376521	http://www.ensembl.org/id/ENST00000376521
Ensembl	ENST00000445167	http://www.ensembl.org/id/ENST00000445167
Ensembl	ENST00000452555	http://www.ensembl.org/id/ENST00000452555
Ensembl	ENST00000635285	http://www.ensembl.org/id/ENST00000635285
Ensembl	ENST00000635589	http://www.ensembl.org/id/ENST00000635589
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005351	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005351
GO_function	GO:0005459	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005459
GO_process	GO:0006012	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006012
GO_process	GO:0015785	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015785
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GeneCards	SLC35A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC35A2
GeneID	7355	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7355
GeneTree	ENSGT00550000074563	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074563
HGNC	HGNC:11022	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11022
HOGENOM	HOG000231358	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231358&db=HOGENOM6
HOVERGEN	HBG071267	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG071267&db=HOVERGEN
HPA	HPA036087	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA036087
InParanoid	P78381	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P78381
IntAct	P78381	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P78381*
InterPro	IPR007271	http://www.ebi.ac.uk/interpro/entry/IPR007271
Jabion	7355	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7355
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00119	http://www.genome.jp/dbget-bin/www_bget?H00119
KEGG_Disease	H00606	http://www.genome.jp/dbget-bin/www_bget?H00606
KEGG_Gene	hsa:7355	http://www.genome.jp/dbget-bin/www_bget?hsa:7355
KEGG_Orthology	KO:K15272	http://www.genome.jp/dbget-bin/www_bget?KO:K15272
MIM	300896	http://www.ncbi.nlm.nih.gov/omim/300896
MIM	314375	http://www.ncbi.nlm.nih.gov/omim/314375
OMA	FAKLITC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FAKLITC
Orphanet	356961	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=356961
OrthoDB	EOG091G0CHS	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0CHS
PANTHER	PTHR10231	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10231
PSORT	swissprot:S35A2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S35A2_HUMAN
PSORT-B	swissprot:S35A2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S35A2_HUMAN
PSORT2	swissprot:S35A2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S35A2_HUMAN
Pfam	PF04142	http://pfam.xfam.org/family/PF04142
PharmGKB	PA35890	http://www.pharmgkb.org/do/serve?objId=PA35890&objCls=Gene
Phobius	swissprot:S35A2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S35A2_HUMAN
PhylomeDB	P78381	http://phylomedb.org/?seqid=P78381
ProteinModelPortal	P78381	http://www.proteinmodelportal.org/query/uniprot/P78381
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	23089177	http://www.ncbi.nlm.nih.gov/pubmed/23089177
PubMed	23561849	http://www.ncbi.nlm.nih.gov/pubmed/23561849
PubMed	24115232	http://www.ncbi.nlm.nih.gov/pubmed/24115232
PubMed	8128316	http://www.ncbi.nlm.nih.gov/pubmed/8128316
PubMed	8889805	http://www.ncbi.nlm.nih.gov/pubmed/8889805
PubMed	9010752	http://www.ncbi.nlm.nih.gov/pubmed/9010752
Reactome	R-HSA-727802	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-727802
RefSeq	NP_001027460	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001027460
RefSeq	NP_001035963	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001035963
RefSeq	NP_001269576	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269576
RefSeq	NP_001269577	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269577
RefSeq	NP_001269578	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269578
RefSeq	NP_001269579	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269579
RefSeq	NP_001269580	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269580
RefSeq	NP_005651	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005651
STRING	9606.ENSP00000247138	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000247138&targetmode=cogs
TCDB	2.A.7.12	http://www.tcdb.org/search/result.php?tc=2.A.7.12
UCSC	uc004dlo	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004dlo&org=rat
UniGene	Hs.21899	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.21899
UniProtKB	S35A2_HUMAN	http://www.uniprot.org/uniprot/S35A2_HUMAN
UniProtKB-AC	P78381	http://www.uniprot.org/uniprot/P78381
charge	swissprot:S35A2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S35A2_HUMAN
eggNOG	COG0697	http://eggnogapi.embl.de/nog_data/html/tree/COG0697
eggNOG	KOG2234	http://eggnogapi.embl.de/nog_data/html/tree/KOG2234
epestfind	swissprot:S35A2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S35A2_HUMAN
garnier	swissprot:S35A2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S35A2_HUMAN
helixturnhelix	swissprot:S35A2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S35A2_HUMAN
hmoment	swissprot:S35A2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S35A2_HUMAN
iep	swissprot:S35A2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S35A2_HUMAN
inforesidue	swissprot:S35A2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S35A2_HUMAN
neXtProt	NX_P78381	http://www.nextprot.org/db/entry/NX_P78381
octanol	swissprot:S35A2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S35A2_HUMAN
pepcoil	swissprot:S35A2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S35A2_HUMAN
pepdigest	swissprot:S35A2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S35A2_HUMAN
pepinfo	swissprot:S35A2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S35A2_HUMAN
pepnet	swissprot:S35A2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S35A2_HUMAN
pepstats	swissprot:S35A2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S35A2_HUMAN
pepwheel	swissprot:S35A2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S35A2_HUMAN
pepwindow	swissprot:S35A2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S35A2_HUMAN
sigcleave	swissprot:S35A2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S35A2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ITBP1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=ICAP1-alpha; IsoId=O14713-1; Sequence=Displayed; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=2; Synonyms=ICAP1-beta; IsoId=O14713-2; Sequence=VSP_003898; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 
# AltName	ITBP1_HUMAN	Integrin cytoplasmic domain-associated protein 1
# BioGrid	114689	13
# CCDS	CCDS1662	-. [O14713-1]
# CCDS	CCDS1663	-. [O14713-2]
# ChiTaRS	ITGB1BP1	human
# Ensembl	ENST00000238091	ENSP00000238091; ENSG00000119185. [O14713-2]
# Ensembl	ENST00000355346	ENSP00000347504; ENSG00000119185. [O14713-1]
# Ensembl	ENST00000360635	ENSP00000353850; ENSG00000119185. [O14713-1]
# Ensembl	ENST00000488451	ENSP00000419524; ENSG00000119185. [O14713-2]
# ExpressionAtlas	O14713	baseline and differential
# FUNCTION	ITBP1_HUMAN	Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin- dependent manner. Involved in the regulation of beta-1 integrin- containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin-and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter. {ECO 0000269|PubMed 11741838, ECO 0000269|PubMed 11807099, ECO 0000269|PubMed 11919189, ECO 0000269|PubMed 12473654, ECO 0000269|PubMed 15703214, ECO 0000269|PubMed 17916086, ECO 0000269|PubMed 20616313, ECO 0000269|PubMed 21768292, ECO 0000269|Ref.19}. 
# GO_component	GO:0001726	ruffle; IDA:HGNC.
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005829	cytosol; IDA:HGNC.
# GO_component	GO:0005856	cytoskeleton; ISS:UniProtKB.
# GO_component	GO:0005886	plasma membrane; ISS:UniProtKB.
# GO_component	GO:0016020	membrane; NAS:UniProtKB.
# GO_component	GO:0030027	lamellipodium; IDA:HGNC.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_component	GO:0071944	cell periphery; IDA:UniProtKB.
# GO_function	GO:0005092	GDP-dissociation inhibitor activity; IDA:UniProtKB.
# GO_function	GO:0005178	integrin binding; IDA:UniProtKB.
# GO_function	GO:0008565	protein transporter activity; IDA:UniProtKB.
# GO_function	GO:0032403	protein complex binding; IDA:UniProtKB.
# GO_process	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis; IDA:UniProtKB.
# GO_process	GO:0006351	transcription, DNA-templated; IEA:UniProtKB-KW.
# GO_process	GO:0006469	negative regulation of protein kinase activity; IDA:UniProtKB.
# GO_process	GO:0006933	negative regulation of cell adhesion involved in substrate-bound cell migration; ISS:UniProtKB.
# GO_process	GO:0007160	cell-matrix adhesion; IDA:UniProtKB.
# GO_process	GO:0007219	Notch signaling pathway; IEA:UniProtKB-KW.
# GO_process	GO:0007229	integrin-mediated signaling pathway; IDA:UniProtKB.
# GO_process	GO:0008284	positive regulation of cell proliferation; IDA:UniProtKB.
# GO_process	GO:0008285	negative regulation of cell proliferation; IDA:UniProtKB.
# GO_process	GO:0010595	positive regulation of endothelial cell migration; IDA:UniProtKB.
# GO_process	GO:0010764	negative regulation of fibroblast migration; ISS:UniProtKB.
# GO_process	GO:0015031	protein transport; IDA:UniProtKB.
# GO_process	GO:0016477	cell migration; TAS:HGNC.
# GO_process	GO:0030154	cell differentiation; IEA:UniProtKB-KW.
# GO_process	GO:0031214	biomineral tissue development; IEA:UniProtKB-KW.
# GO_process	GO:0032091	negative regulation of protein binding; IDA:UniProtKB.
# GO_process	GO:0032148	activation of protein kinase B activity; IDA:UniProtKB.
# GO_process	GO:0033622	integrin activation; ISS:UniProtKB.
# GO_process	GO:0033628	regulation of cell adhesion mediated by integrin; ISS:UniProtKB.
# GO_process	GO:0035148	tube formation; IDA:UniProtKB.
# GO_process	GO:0035556	intracellular signal transduction; TAS:ProtInc.
# GO_process	GO:0035924	cellular response to vascular endothelial growth factor stimulus; IDA:UniProtKB.
# GO_process	GO:0043087	regulation of GTPase activity; IDA:UniProtKB.
# GO_process	GO:0043113	receptor clustering; ISS:UniProtKB.
# GO_process	GO:0044344	cellular response to fibroblast growth factor stimulus; IDA:UniProtKB.
# GO_process	GO:0045747	positive regulation of Notch signaling pathway; IDA:UniProtKB.
# GO_process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
# GO_process	GO:0050880	regulation of blood vessel size; IDA:UniProtKB.
# GO_process	GO:0051451	myoblast migration; ISS:UniProtKB.
# GO_process	GO:0051496	positive regulation of stress fiber assembly; ISS:UniProtKB.
# GO_process	GO:0051781	positive regulation of cell division; IEA:UniProtKB-KW.
# GO_process	GO:0051894	positive regulation of focal adhesion assembly; IEA:Ensembl.
# GO_process	GO:0051895	negative regulation of focal adhesion assembly; IDA:UniProtKB.
# GO_process	GO:0051897	positive regulation of protein kinase B signaling; IDA:UniProtKB.
# GO_process	GO:0070373	negative regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.
# GO_process	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis; IDA:UniProtKB.
# GO_process	GO:0090314	positive regulation of protein targeting to membrane; ISS:UniProtKB.
# GO_process	GO:0090315	negative regulation of protein targeting to membrane; IDA:UniProtKB.
# GO_process	GO:1900025	negative regulation of substrate adhesion-dependent cell spreading; IDA:UniProtKB.
# GO_process	GO:2001044	regulation of integrin-mediated signaling pathway; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005856	cytoskeleton
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0030234	enzyme regulator activity
# GOslim_process	GO:0003013	circulatory system process
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007155	cell adhesion
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0008283	cell proliferation
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0048646	anatomical structure formation involved in morphogenesis
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0048870	cell motility
# GOslim_process	GO:0061024	membrane organization
# Gene3D	2.30.29.30	-; 1.
# Genevisible	O14713	HS
# HGNC	HGNC:23927	ITGB1BP1
# INTERACTION	ITBP1_HUMAN	Q6PIW4 FIGNL1; NbExp=3; IntAct=EBI-2127319, EBI-8468390; P22392 NME2; NbExp=7; IntAct=EBI-2127367, EBI-713693; 
# IntAct	O14713	10
# InterPro	IPR006020	PTB/PI_dom
# InterPro	IPR011993	PH_dom-like
# InterPro	IPR019517	Integrin-bd_ICAP-1
# MIM	607153	gene
# Organism	ITBP1_HUMAN	Homo sapiens (Human)
# PDB	1K11	Model; -; A=58-196
# PDB	4DX8	X-ray; 2.54 A; A/B/D/E=49-200
# PDB	4DX9	X-ray; 2.99 A; 0/1/2/3/4/5/A/C/E/G/I/K/M/O/Q/S/U/W/Y/a/c/e/g/i/k/m/o/q/s/u=49-200
# PDB	4JIF	X-ray; 1.70 A; A=49-200
# PTM	ITBP1_HUMAN	Phosphorylation at Thr-38 seems to enhance integrin alpha5beta1-mediated cell adhesion. The degree of phosphorylation is regulated by integrin-dependent cell-matrix interaction. {ECO 0000269|PubMed 9281591, ECO 0000269|PubMed 9813144, ECO 0000269|PubMed 9867804}. 
# Pfam	PF10480	ICAP-1_inte_bdg
# Proteomes	UP000005640	Chromosome 2
# RecName	ITBP1_HUMAN	Integrin beta-1-binding protein 1
# RefSeq	NP_001305995	NM_001319066.1. [O14713-1]
# RefSeq	NP_001305996	NM_001319067.1. [O14713-1]
# RefSeq	NP_001305997	NM_001319068.1. [O14713-1]
# RefSeq	NP_004754	NM_004763.4. [O14713-1]
# RefSeq	NP_071729	NM_022334.4. [O14713-2]
# RefSeq	XP_005246240	XM_005246183.4. [O14713-1]
# RefSeq	XP_005246241	XM_005246184.4. [O14713-1]
# RefSeq	XP_005246242	XM_005246185.4. [O14713-1]
# RefSeq	XP_005246246	XM_005246189.4. [O14713-2]
# RefSeq	XP_006711966	XM_006711903.3. [O14713-1]
# RefSeq	XP_011508718	XM_011510416.2. [O14713-1]
# RefSeq	XP_016860756	XM_017005267.1. [O14713-1]
# RefSeq	XP_016860757	XM_017005268.1. [O14713-1]
# RefSeq	XP_016860758	XM_017005269.1. [O14713-2]
# RefSeq	XP_016860759	XM_017005270.1. [O14713-2]
# SIMILARITY	Contains 1 PID domain. {ECO	0000305}.
# SMART	SM00462	PTB
# SUBCELLULAR LOCATION	ITBP1_HUMAN	Nucleus. Cytoplasm. Cytoplasm, cytoskeleton {ECO 0000250}. Cell membrane {ECO 0000250}. Cell projection, lamellipodium. Cell projection, ruffle. Note=Nucleocytoplasmic shuttling protein; shuttles between nucleus and cytoplasm in a integrin-dependent manner; probably sequestered in the cytosol by ITGB1. Its localization is dependent on the stage of cell spreading on fibronectin; cytoplasmic in case of round cells, corresponding to the initial step of cell spreading, or nuclear in case of well spread cells. Colocalizes with ROCK1 and NME2 at beta-1 integrin engagement sites. Together with ITGB1 and NME2 is recruited to beta-1 integrin-rich peripheral ruffles and lamellipodia during initial cell spreading on fibronectin and/or collagen. 
# SUBUNIT	ITBP1_HUMAN	Interacts (via N-terminus and PTB domain) with ROCK1 (By similarity). Found in a complex, at least composed of ITGB1BP1, KRIT1 and RAP1A. Interacts (via C-terminal region) with ITGB1 (via C-terminal cytoplasmic tail); the interaction prevents talin TLN1 binding to ITGB1 and KRIT1 and ITGB1 compete for the same binding site. Interacts with KRIT1 (via N-terminal NPXY motif); the interaction induces the opening conformation of KRIT1 and KRIT1 and ITGB1 compete for the same binding site. Isoform 2 does not interact with ITGB1. Interacts with CDC42 (GTP- or GDP-bound form); the interaction is increased with the CDC42-membrane bound forms and prevents both CDC42 activation and cell spreading. Interacts (via C-terminal domain region) with NME2. Interacts with FERMT2 and RAC1. {ECO 0000250, ECO 0000269|PubMed 11741838, ECO 0000269|PubMed 11741908, ECO 0000269|PubMed 11807099, ECO 0000269|PubMed 11854171, ECO 0000269|PubMed 11919189, ECO 0000269|PubMed 12473654, ECO 0000269|PubMed 17916086, ECO 0000269|PubMed 21768292, ECO 0000269|PubMed 9281591, ECO 0000269|PubMed 9867804, ECO 0000269|Ref.19}. 
# SUPFAM	SSF50729	SSF50729
# TISSUE SPECIFICITY	ITBP1_HUMAN	Expressed in endothelial cells and fibroblasts (at protein level). Ubiquitously expressed. Expressed in intestine, colon, testis, ovary, thymus, spleen and prostate. {ECO 0000269|PubMed 9281591, ECO 0000269|PubMed 9867804}. 
# UCSC	uc002qzj	human. [O14713-1]
# eggNOG	ENOG410IFN6	Eukaryota
# eggNOG	ENOG4111GWT	LUCA
BLAST	swissprot:ITBP1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ITBP1_HUMAN
BioCyc	ZFISH:ENSG00000119185-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000119185-MONOMER
COXPRESdb	9270	http://coxpresdb.jp/data/gene/9270.shtml
CleanEx	HS_ITGB1BP1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ITGB1BP1
DOI	10.1006/bbrc.1998.9592	http://dx.doi.org/10.1006/bbrc.1998.9592
DOI	10.1016/j.molcel.2012.12.005	http://dx.doi.org/10.1016/j.molcel.2012.12.005
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1074/jbc.274.1.11	http://dx.doi.org/10.1074/jbc.274.1.11
DOI	10.1074/jbc.M109031200	http://dx.doi.org/10.1074/jbc.M109031200
DOI	10.1074/jbc.M200200200	http://dx.doi.org/10.1074/jbc.M200200200
DOI	10.1074/jbc.M211258200	http://dx.doi.org/10.1074/jbc.M211258200
DOI	10.1083/jcb.138.5.1149	http://dx.doi.org/10.1083/jcb.138.5.1149
DOI	10.1083/jcb.200108030	http://dx.doi.org/10.1083/jcb.200108030
DOI	10.1083/jcb.201007108	http://dx.doi.org/10.1083/jcb.201007108
DOI	10.1091/mbc.E04-08-0744	http://dx.doi.org/10.1091/mbc.E04-08-0744
DOI	10.1093/hmg/10.25.2953	http://dx.doi.org/10.1093/hmg/10.25.2953
DOI	10.1093/hmg/11.4.389	http://dx.doi.org/10.1093/hmg/11.4.389
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1742-4658.2007.06068.x	http://dx.doi.org/10.1111/j.1742-4658.2007.06068.x
DOI	10.1161/CIRCRESAHA.110.217257	http://dx.doi.org/10.1161/CIRCRESAHA.110.217257
DOI	10.1186/gb-2004-5-2-r8	http://dx.doi.org/10.1186/gb-2004-5-2-r8
EMBL	AC080162	http://www.ebi.ac.uk/ena/data/view/AC080162
EMBL	AF012023	http://www.ebi.ac.uk/ena/data/view/AF012023
EMBL	AF012024	http://www.ebi.ac.uk/ena/data/view/AF012024
EMBL	BC012264	http://www.ebi.ac.uk/ena/data/view/BC012264
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
Ensembl	ENST00000238091	http://www.ensembl.org/id/ENST00000238091
Ensembl	ENST00000355346	http://www.ensembl.org/id/ENST00000355346
Ensembl	ENST00000360635	http://www.ensembl.org/id/ENST00000360635
Ensembl	ENST00000488451	http://www.ensembl.org/id/ENST00000488451
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0001726	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001726
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0030027	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030027
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_component	GO:0071944	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071944
GO_function	GO:0005092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005092
GO_function	GO:0005178	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005178
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0032403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032403
GO_process	GO:0002043	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002043
GO_process	GO:0006351	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351
GO_process	GO:0006469	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006469
GO_process	GO:0006933	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006933
GO_process	GO:0007160	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007160
GO_process	GO:0007219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007219
GO_process	GO:0007229	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007229
GO_process	GO:0008284	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008284
GO_process	GO:0008285	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008285
GO_process	GO:0010595	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010595
GO_process	GO:0010764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010764
GO_process	GO:0015031	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031
GO_process	GO:0016477	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016477
GO_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GO_process	GO:0031214	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031214
GO_process	GO:0032091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032091
GO_process	GO:0032148	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032148
GO_process	GO:0033622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033622
GO_process	GO:0033628	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033628
GO_process	GO:0035148	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035148
GO_process	GO:0035556	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035556
GO_process	GO:0035924	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035924
GO_process	GO:0043087	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043087
GO_process	GO:0043113	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043113
GO_process	GO:0044344	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044344
GO_process	GO:0045747	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045747
GO_process	GO:0045944	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045944
GO_process	GO:0050880	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050880
GO_process	GO:0051451	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051451
GO_process	GO:0051496	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051496
GO_process	GO:0051781	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051781
GO_process	GO:0051894	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051894
GO_process	GO:0051895	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051895
GO_process	GO:0051897	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051897
GO_process	GO:0070373	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070373
GO_process	GO:0090051	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090051
GO_process	GO:0090314	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090314
GO_process	GO:0090315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090315
GO_process	GO:1900025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900025
GO_process	GO:2001044	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001044
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0030234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234
GOslim_process	GO:0003013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003013
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0008283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008283
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0048646	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048646
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
Gene3D	2.30.29.30	http://www.cathdb.info/version/latest/superfamily/2.30.29.30
GeneCards	ITGB1BP1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ITGB1BP1
GeneID	9270	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9270
GeneTree	ENSGT00390000003990	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000003990
HGNC	HGNC:23927	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:23927
HOGENOM	HOG000015089	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000015089&db=HOGENOM6
HOVERGEN	HBG052155	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052155&db=HOVERGEN
InParanoid	O14713	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O14713
IntAct	O14713	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O14713*
InterPro	IPR006020	http://www.ebi.ac.uk/interpro/entry/IPR006020
InterPro	IPR011993	http://www.ebi.ac.uk/interpro/entry/IPR011993
InterPro	IPR019517	http://www.ebi.ac.uk/interpro/entry/IPR019517
Jabion	9270	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9270
KEGG_Gene	hsa:9270	http://www.genome.jp/dbget-bin/www_bget?hsa:9270
MIM	607153	http://www.ncbi.nlm.nih.gov/omim/607153
OMA	RMLCYDD	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RMLCYDD
OrthoDB	EOG091G16AY	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G16AY
PDB	1K11	http://www.ebi.ac.uk/pdbe-srv/view/entry/1K11
PDB	4DX8	http://www.ebi.ac.uk/pdbe-srv/view/entry/4DX8
PDB	4DX9	http://www.ebi.ac.uk/pdbe-srv/view/entry/4DX9
PDB	4JIF	http://www.ebi.ac.uk/pdbe-srv/view/entry/4JIF
PDBsum	1K11	http://www.ebi.ac.uk/pdbsum/1K11
PDBsum	4DX8	http://www.ebi.ac.uk/pdbsum/4DX8
PDBsum	4DX9	http://www.ebi.ac.uk/pdbsum/4DX9
PDBsum	4JIF	http://www.ebi.ac.uk/pdbsum/4JIF
PSORT	swissprot:ITBP1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ITBP1_HUMAN
PSORT-B	swissprot:ITBP1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ITBP1_HUMAN
PSORT2	swissprot:ITBP1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ITBP1_HUMAN
Pfam	PF10480	http://pfam.xfam.org/family/PF10480
PharmGKB	PA134913590	http://www.pharmgkb.org/do/serve?objId=PA134913590&objCls=Gene
Phobius	swissprot:ITBP1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ITBP1_HUMAN
PhylomeDB	O14713	http://phylomedb.org/?seqid=O14713
ProteinModelPortal	O14713	http://www.proteinmodelportal.org/query/uniprot/O14713
PubMed	11741838	http://www.ncbi.nlm.nih.gov/pubmed/11741838
PubMed	11741908	http://www.ncbi.nlm.nih.gov/pubmed/11741908
PubMed	11807099	http://www.ncbi.nlm.nih.gov/pubmed/11807099
PubMed	11854171	http://www.ncbi.nlm.nih.gov/pubmed/11854171
PubMed	11919189	http://www.ncbi.nlm.nih.gov/pubmed/11919189
PubMed	12473654	http://www.ncbi.nlm.nih.gov/pubmed/12473654
PubMed	14759258	http://www.ncbi.nlm.nih.gov/pubmed/14759258
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15703214	http://www.ncbi.nlm.nih.gov/pubmed/15703214
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	17916086	http://www.ncbi.nlm.nih.gov/pubmed/17916086
PubMed	20616313	http://www.ncbi.nlm.nih.gov/pubmed/20616313
PubMed	21768292	http://www.ncbi.nlm.nih.gov/pubmed/21768292
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	9281591	http://www.ncbi.nlm.nih.gov/pubmed/9281591
PubMed	9813144	http://www.ncbi.nlm.nih.gov/pubmed/9813144
PubMed	9867804	http://www.ncbi.nlm.nih.gov/pubmed/9867804
RefSeq	NP_001305995	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001305995
RefSeq	NP_001305996	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001305996
RefSeq	NP_001305997	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001305997
RefSeq	NP_004754	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004754
RefSeq	NP_071729	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_071729
RefSeq	XP_005246240	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005246240
RefSeq	XP_005246241	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005246241
RefSeq	XP_005246242	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005246242
RefSeq	XP_005246246	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005246246
RefSeq	XP_006711966	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006711966
RefSeq	XP_011508718	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011508718
RefSeq	XP_016860756	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016860756
RefSeq	XP_016860757	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016860757
RefSeq	XP_016860758	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016860758
RefSeq	XP_016860759	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016860759
SMART	SM00462	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00462
SMR	O14713	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O14713
STRING	9606.ENSP00000347504	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000347504&targetmode=cogs
SUPFAM	SSF50729	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50729
UCSC	uc002qzj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002qzj&org=rat
UniGene	Hs.467662	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.467662
UniProtKB	ITBP1_HUMAN	http://www.uniprot.org/uniprot/ITBP1_HUMAN
UniProtKB-AC	O14713	http://www.uniprot.org/uniprot/O14713
charge	swissprot:ITBP1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ITBP1_HUMAN
eggNOG	ENOG410IFN6	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IFN6
eggNOG	ENOG4111GWT	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111GWT
epestfind	swissprot:ITBP1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ITBP1_HUMAN
garnier	swissprot:ITBP1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ITBP1_HUMAN
helixturnhelix	swissprot:ITBP1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ITBP1_HUMAN
hmoment	swissprot:ITBP1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ITBP1_HUMAN
iep	swissprot:ITBP1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ITBP1_HUMAN
inforesidue	swissprot:ITBP1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ITBP1_HUMAN
neXtProt	NX_O14713	http://www.nextprot.org/db/entry/NX_O14713
octanol	swissprot:ITBP1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ITBP1_HUMAN
pepcoil	swissprot:ITBP1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ITBP1_HUMAN
pepdigest	swissprot:ITBP1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ITBP1_HUMAN
pepinfo	swissprot:ITBP1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ITBP1_HUMAN
pepnet	swissprot:ITBP1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ITBP1_HUMAN
pepstats	swissprot:ITBP1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ITBP1_HUMAN
pepwheel	swissprot:ITBP1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ITBP1_HUMAN
pepwindow	swissprot:ITBP1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ITBP1_HUMAN
sigcleave	swissprot:ITBP1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ITBP1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	MDR3_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P21439-1; Sequence=Displayed; Name=2; IsoId=P21439-2; Sequence=VSP_023263; Name=3; IsoId=P21439-3; Sequence=VSP_046258, VSP_023263; Note=No experimental confirmation available. Gene prediction based on EST data.; 
# AltName	ATP-binding cassette sub-family B member 4 {ECO:0000312|HGNC	HGNC:45}
# AltName	Multidrug resistance protein 3 {ECO:0000303|PubMed	2892668}
# AltName	P-glycoprotein 3 {ECO:0000250|UniProtKB	Q08201}
# BioGrid	111263	2
# CATALYTIC ACTIVITY	MDR3_HUMAN	ATP + H(2)O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out). 
# CCDS	CCDS5605	-. [P21439-2]
# CCDS	CCDS5606	-. [P21439-1]
# CCDS	CCDS5607	-. [P21439-3]
# DISEASE	MDR3_HUMAN	Cholestasis of pregnancy, intrahepatic 3 (ICP3) [MIM 614972]  A liver disorder of pregnancy. It presents during the second or, more commonly, the third trimester of pregnancy with intense pruritus which becomes more severe with advancing gestation and cholestasis. It causes fetal distress, spontaneous premature delivery and intrauterine death. Patients have spontaneous and progressive disappearance of cholestasis after delivery. Cholestasis results from abnormal biliary transport from the liver into the small intestine. {ECO 0000269|PubMed 10767346, ECO 0000269|PubMed 12746424, ECO 0000269|PubMed 15077010}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	MDR3_HUMAN	Cholestasis, progressive familial intrahepatic, 3 (PFIC3) [MIM 602347]  A disorder characterized by early onset of cholestasis that progresses to hepatic fibrosis, cirrhosis, and end-stage liver disease before adulthood. {ECO 0000269|PubMed 11313315, ECO 0000269|PubMed 12671900, ECO 0000269|PubMed 17726488, ECO 0000269|PubMed 21119540, ECO 0000269|PubMed 24045840, ECO 0000269|PubMed 24594635, ECO 0000269|PubMed 24806754, ECO 0000269|PubMed 9419367}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	MDR3_HUMAN	Gallbladder disease 1 (GBD1) [MIM 600803]  One of the major digestive diseases. Gallstones composed of cholesterol (cholelithiasis) are the common manifestations in western countries. Most people with gallstones, however, remain asymptomatic through their lifetimes. {ECO 0000269|PubMed 11313316, ECO 0000269|PubMed 12891548, ECO 0000269|PubMed 22331132, ECO 0000269|PubMed 23533021, ECO 0000269|PubMed 24723470, ECO 0000269|Ref.2}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB01394	Colchicine
# DrugBank	DB06207	Silodosin
# DrugBank	DB06414	Etravirine
# ENZYME REGULATION	MDR3_HUMAN	Translocation activity is inhibited by the ATPase inhibitor vanadate and the calcium channel blocker verapamil (PubMed 17523162, PubMed 23468132). Translocation activity is enhanced by the addition of the bile salt taurocholate (PubMed 17523162, PubMed 23468132). {ECO 0000269|PubMed 17523162, ECO 0000269|PubMed 23468132}. 
# Ensembl	ENST00000265723	ENSP00000265723; ENSG00000005471. [P21439-1]
# Ensembl	ENST00000358400	ENSP00000351172; ENSG00000005471. [P21439-3]
# Ensembl	ENST00000359206	ENSP00000352135; ENSG00000005471. [P21439-2]
# Ensembl	ENST00000453593	ENSP00000392983; ENSG00000005471. [P21439-3]
# ExpressionAtlas	P21439	baseline and differential
# FUNCTION	MDR3_HUMAN	Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed 7957936, PubMed 8898203, PubMed 9366571, PubMed 17523162, PubMed 23468132, PubMed 24806754, PubMed 24723470, PubMed 24594635, PubMed 21820390). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to fu rther enrichment of SM and cholesterol in raft membranes in hepatocytes (PubMed 23468132). Required for proper phospholipid bile formation (By similarity). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP- dependent manner (PubMed 24045840). May promote biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed 9366571). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed 21820390). Does not confer multidrug resistance (By similarity). {ECO 0000250|UniProtKB P21440, ECO 0000269|PubMed 17523162, ECO 0000269|PubMed 21820390, ECO 0000269|PubMed 23468132, ECO 0000269|PubMed 24045840, ECO 0000269|PubMed 24594635, ECO 0000269|PubMed 24723470, ECO 0000269|PubMed 24806754, ECO 0000269|PubMed 7957936, ECO 0000269|PubMed 8898203, ECO 0000269|PubMed 9366571}. 
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_component	GO:0030136	clathrin-coated vesicle; IEA:UniProtKB-SubCell.
# GO_component	GO:0045121	membrane raft; IEA:UniProtKB-SubCell.
# GO_component	GO:0046581	intercellular canaliculus; IEA:Ensembl.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0005548	phospholipid transporter activity; TAS:Reactome.
# GO_function	GO:0008525	phosphatidylcholine transporter activity; IDA:UniProtKB.
# GO_function	GO:0008559	xenobiotic-transporting ATPase activity; IEA:UniProtKB-EC.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; IDA:UniProtKB.
# GO_function	GO:0090554	phosphatidylcholine-translocating ATPase activity; IDA:UniProtKB.
# GO_process	GO:0002481	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; IBA:GO_Central.
# GO_process	GO:0002485	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; IBA:GO_Central.
# GO_process	GO:0002489	antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; IBA:GO_Central.
# GO_process	GO:0002591	positive regulation of antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central.
# GO_process	GO:0006629	lipid metabolic process; TAS:ProtInc.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0032376	positive regulation of cholesterol transport; IDA:UniProtKB.
# GO_process	GO:0032782	bile acid secretion; ISS:UniProtKB.
# GO_process	GO:0042493	response to drug; TAS:ProtInc.
# GO_process	GO:0045332	phospholipid translocation; IMP:UniProtKB.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GO_process	GO:0055088	lipid homeostasis; IDA:UniProtKB.
# GO_process	GO:0061092	positive regulation of phospholipid translocation; IDA:UniProtKB.
# GO_process	GO:1901557	response to fenofibrate; ISS:UniProtKB.
# GO_process	GO:1903413	cellular response to bile acid; IDA:UniProtKB.
# GO_process	GO:2001140	positive regulation of phospholipid transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# GOslim_process	GO:0061024	membrane organization
# Gene3D	3.40.50.300	-; 2.
# Genevisible	P21439	HS
# HGNC	HGNC:45	ABCB4
# INDUCTION	MDR3_HUMAN	Up-regulated by PPARA (PubMed 24122873). Up-regulated by compounds that cause peroxisome proliferation, such as fenofibrate (at protein level). Up-regulated by bezafibrate (PubMed 15258199). Up-regulated by compounds that cause peroxisome proliferation, such as fenofibrate, bezafibrate and gemfibrozil (PubMed 24122873). {ECO 0000269|PubMed 15258199, ECO 0000269|PubMed 24122873}. 
# IntAct	P21439	3
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR011527	ABC1_TM_dom
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Disease	H00624	[Inherited metabolic disease; Liver disease] North American Indian childhood cirrhosis (NAIC)
# KEGG_Disease	H01213	[Digestive disease] Cholelithiasis
# KEGG_Pathway	ko02010	ABC transporters
# KEGG_Pathway	ko04976	Bile secretion
# MIM	171060	gene
# MIM	600803	phenotype
# MIM	602347	phenotype
# MIM	614972	phenotype
# Organism	MDR3_HUMAN	Homo sapiens (Human)
# Orphanet	69663	Low phospholipid associated cholelithiasis
# Orphanet	69665	Intrahepatic cholestasis of pregnancy
# Orphanet	79305	Progressive familial intrahepatic cholestasis type 3
# PIR	JS0051	DVHU3
# PROSITE	PS00211	ABC_TRANSPORTER_1; 2
# PROSITE	PS50893	ABC_TRANSPORTER_2; 2
# PROSITE	PS50929	ABC_TM1F; 2
# PTM	MDR3_HUMAN	Glycosylated (PubMed 17523162, PubMed 24723470, PubMed 21820390). {ECO 0000269|PubMed 17523162, ECO 0000269|PubMed 21820390, ECO 0000269|PubMed 24723470}. 
# PTM	MDR3_HUMAN	Phosphorylated (PubMed 24723470). Phosphorylation on Thr-34 is required for PC efflux activity. Phosphorylation occurs on serine and threonine residues in a protein kinase A- or C- dependent manner (PubMed 24723470). May be phosphorylated on Thr- 44 and Ser-49 (PubMed 24723470). {ECO 0000269|PubMed 24723470}. 
# Pfam	PF00005	ABC_tran; 2
# Pfam	PF00664	ABC_membrane; 2
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-1989781	PPARA activates gene expression
# Reactome	R-HSA-382556	ABC-family proteins mediated transport
# RecName	Phosphatidylcholine translocator ABCB4 {ECO	0000305}
# RefSeq	NP_000434	NM_000443.3. [P21439-2]
# RefSeq	NP_061337	NM_018849.2. [P21439-1]
# RefSeq	NP_061338	NM_018850.2. [P21439-3]
# RefSeq	XP_011514615	XM_011516313.2. [P21439-3]
# SEQUENCE CAUTION	Sequence=CAA84542.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 2 ABC transmembrane type-1 domains. {ECO:0000255|PROSITE-ProRule	PRU00441}. 
# SIMILARITY	Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA; 2
# SUBCELLULAR LOCATION	MDR3_HUMAN	Cell membrane {ECO 0000269|PubMed 23468132, ECO 0000269|PubMed 24045840, ECO 0000269|PubMed 24806754}; Multi- pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00441}. Apical cell membrane {ECO 0000269|PubMed 15258199, ECO 0000269|PubMed 19674157, ECO 0000269|PubMed 21820390, ECO 0000269|PubMed 24122873, ECO 0000269|PubMed 24594635, ECO 0000269|PubMed 24723470, ECO 0000269|PubMed 8898203}; Multi- pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00441}. Membrane raft {ECO 0000269|PubMed 23468132}. Cytoplasm {ECO 0000269|PubMed 24045840}. Cytoplasmic vesicle, clathrin- coated vesicle {ECO 0000250|UniProtKB Q08201}. Note=Localized at the apical canalicular membrane of the epithelial cells lining the lumen of the bile canaliculi and biliary ductules (By similarity). Transported from the Golgi to the apical bile canalicular membrane in a RACK1-dependent manner (PubMed 19674157). Redistributed into pseudocanaliculi formed between cells in a bezafibrate- or PPARA- dependent manner (PubMed 15258199). Localized preferentially in lipid nonraft domains of canalicular plasma membranes (PubMed 23468132). {ECO 0000250|UniProtKB P21440, ECO 0000269|PubMed 15258199, ECO 0000269|PubMed 19674157, ECO 0000269|PubMed 23468132}. 
# SUBUNIT	MDR3_HUMAN	May interact with RACK1 (PubMed 19674157). Interacts with HAX1 (By similarity). {ECO 0000250|UniProtKB Q08201, ECO 0000269|PubMed 19674157}. 
# SUPFAM	SSF52540	SSF52540; 2
# SUPFAM	SSF90123	SSF90123; 2
# TCDB	3.A.1.201	the atp-binding cassette (abc) superfamily
# UCSC	uc003uiv	human. [P21439-1]
# WEB RESOURCE	MDR3_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=P21439";
# WEB RESOURCE	MDR3_HUMAN	Name=NIEHS-SNPs; URL="http //egp.gs.washington.edu/data/abcb4/"; 
# eggNOG	COG1132	LUCA
# eggNOG	KOG0055	Eukaryota
BLAST	swissprot:MDR3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MDR3_HUMAN
BioCyc	ZFISH:HS00144-MONOMER	http://biocyc.org/getid?id=ZFISH:HS00144-MONOMER
COXPRESdb	5244	http://coxpresdb.jp/data/gene/5244.shtml
CleanEx	HS_ABCB4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCB4
DOI	10.1002/hep.21591	http://dx.doi.org/10.1002/hep.21591
DOI	10.1002/hep.26424	http://dx.doi.org/10.1002/hep.26424
DOI	10.1002/hep.26894	http://dx.doi.org/10.1002/hep.26894
DOI	10.1002/hep.26970	http://dx.doi.org/10.1002/hep.26970
DOI	10.1002/hep.27170	http://dx.doi.org/10.1002/hep.27170
DOI	10.1007/s00428-012-1202-6	http://dx.doi.org/10.1007/s00428-012-1202-6
DOI	10.1016/0014-5793(94)01135-4	http://dx.doi.org/10.1016/0014-5793(94)01135-4
DOI	10.1016/0167-4781(94)00214-N	http://dx.doi.org/10.1016/0167-4781(94)00214-N
DOI	10.1016/0378-1119(88)90057-1	http://dx.doi.org/10.1016/0378-1119(88)90057-1
DOI	10.1016/S0016-5085(03)00898-9	http://dx.doi.org/10.1016/S0016-5085(03)00898-9
DOI	10.1016/S0092-8674(00)81370-7	http://dx.doi.org/10.1016/S0092-8674(00)81370-7
DOI	10.1016/j.dld.2008.12.101	http://dx.doi.org/10.1016/j.dld.2008.12.101
DOI	10.1038/ejhg.2013.214	http://dx.doi.org/10.1038/ejhg.2013.214
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1038/sj.ejhg.5201908	http://dx.doi.org/10.1038/sj.ejhg.5201908
DOI	10.1053/gast.2001.23947	http://dx.doi.org/10.1053/gast.2001.23947
DOI	10.1053/gast.2001.23984	http://dx.doi.org/10.1053/gast.2001.23984
DOI	10.1053/gast.2003.50144	http://dx.doi.org/10.1053/gast.2003.50144
DOI	10.1053/j.gastro.2011.07.042	http://dx.doi.org/10.1053/j.gastro.2011.07.042
DOI	10.1073/pnas.95.1.282	http://dx.doi.org/10.1073/pnas.95.1.282
DOI	10.1093/hmg/9.8.1209	http://dx.doi.org/10.1093/hmg/9.8.1209
DOI	10.1097/00008571-200402000-00003	http://dx.doi.org/10.1097/00008571-200402000-00003
DOI	10.1097/01.fpc.0000230418.28091.76	http://dx.doi.org/10.1097/01.fpc.0000230418.28091.76
DOI	10.1097/MPG.0b013e3181f50363	http://dx.doi.org/10.1097/MPG.0b013e3181f50363
DOI	10.1111/j.1872-034X.2009.00544.x	http://dx.doi.org/10.1111/j.1872-034X.2009.00544.x
DOI	10.1124/dmd.105.008854	http://dx.doi.org/10.1124/dmd.105.008854
DOI	10.1126/science.1083423	http://dx.doi.org/10.1126/science.1083423
DOI	10.1136/gutjnl-2014-306896	http://dx.doi.org/10.1136/gutjnl-2014-306896
DOI	10.1136/jmg.40.5.e70	http://dx.doi.org/10.1136/jmg.40.5.e70
DOI	10.1172/JCI119799	http://dx.doi.org/10.1172/JCI119799
DOI	10.1194/jlr.M032425	http://dx.doi.org/10.1194/jlr.M032425
DOI	10.1194/jlr.M400132-JLR200	http://dx.doi.org/10.1194/jlr.M400132-JLR200
DrugBank	DB01394	http://www.drugbank.ca/drugs/DB01394
DrugBank	DB06207	http://www.drugbank.ca/drugs/DB06207
DrugBank	DB06414	http://www.drugbank.ca/drugs/DB06414
EC_number	EC:3.6.3.44	http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.44
EMBL	AC005045	http://www.ebi.ac.uk/ena/data/view/AC005045
EMBL	AC005068	http://www.ebi.ac.uk/ena/data/view/AC005068
EMBL	AC006154	http://www.ebi.ac.uk/ena/data/view/AC006154
EMBL	CH236949	http://www.ebi.ac.uk/ena/data/view/CH236949
EMBL	CH236949	http://www.ebi.ac.uk/ena/data/view/CH236949
EMBL	CH236949	http://www.ebi.ac.uk/ena/data/view/CH236949
EMBL	CH471091	http://www.ebi.ac.uk/ena/data/view/CH471091
EMBL	CH471091	http://www.ebi.ac.uk/ena/data/view/CH471091
EMBL	CH471091	http://www.ebi.ac.uk/ena/data/view/CH471091
EMBL	CH471091	http://www.ebi.ac.uk/ena/data/view/CH471091
EMBL	CH471091	http://www.ebi.ac.uk/ena/data/view/CH471091
EMBL	CH471091	http://www.ebi.ac.uk/ena/data/view/CH471091
EMBL	EF034088	http://www.ebi.ac.uk/ena/data/view/EF034088
EMBL	M23234	http://www.ebi.ac.uk/ena/data/view/M23234
EMBL	X06181	http://www.ebi.ac.uk/ena/data/view/X06181
EMBL	Z35284	http://www.ebi.ac.uk/ena/data/view/Z35284
ENZYME	3.6.3.44	http://enzyme.expasy.org/EC/3.6.3.44
Ensembl	ENST00000265723	http://www.ensembl.org/id/ENST00000265723
Ensembl	ENST00000358400	http://www.ensembl.org/id/ENST00000358400
Ensembl	ENST00000359206	http://www.ensembl.org/id/ENST00000359206
Ensembl	ENST00000453593	http://www.ensembl.org/id/ENST00000453593
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0030136	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030136
GO_component	GO:0045121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045121
GO_component	GO:0046581	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046581
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0005548	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005548
GO_function	GO:0008525	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008525
GO_function	GO:0008559	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008559
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GO_function	GO:0090554	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090554
GO_process	GO:0002481	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002481
GO_process	GO:0002485	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002485
GO_process	GO:0002489	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002489
GO_process	GO:0002591	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002591
GO_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0032376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032376
GO_process	GO:0032782	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032782
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0045332	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045332
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GO_process	GO:0055088	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055088
GO_process	GO:0061092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061092
GO_process	GO:1901557	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901557
GO_process	GO:1903413	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903413
GO_process	GO:2001140	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001140
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCB4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCB4
GeneID	5244	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5244
GeneTree	ENSGT00530000062896	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062896
HGNC	HGNC:45	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:45
HOVERGEN	HBG080809	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG080809&db=HOVERGEN
HPA	HPA049395	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA049395
HPA	HPA053288	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA053288
InParanoid	P21439	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21439
IntAct	P21439	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21439*
IntEnz	3.6.3.44	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.44
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR011527	http://www.ebi.ac.uk/interpro/entry/IPR011527
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	5244	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=5244
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Disease	H00624	http://www.genome.jp/dbget-bin/www_bget?H00624
KEGG_Disease	H01213	http://www.genome.jp/dbget-bin/www_bget?H01213
KEGG_Gene	hsa:5244	http://www.genome.jp/dbget-bin/www_bget?hsa:5244
KEGG_Orthology	KO:K05659	http://www.genome.jp/dbget-bin/www_bget?KO:K05659
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
MIM	171060	http://www.ncbi.nlm.nih.gov/omim/171060
MIM	600803	http://www.ncbi.nlm.nih.gov/omim/600803
MIM	602347	http://www.ncbi.nlm.nih.gov/omim/602347
MIM	614972	http://www.ncbi.nlm.nih.gov/omim/614972
OMA	SEDANYQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SEDANYQ
Orphanet	69663	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=69663
Orphanet	69665	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=69665
Orphanet	79305	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=79305
OrthoDB	EOG091G0HVA	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0HVA
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PROSITE	PS50929	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929
PSORT	swissprot:MDR3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MDR3_HUMAN
PSORT-B	swissprot:MDR3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MDR3_HUMAN
PSORT2	swissprot:MDR3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MDR3_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF00664	http://pfam.xfam.org/family/PF00664
PharmGKB	PA268	http://www.pharmgkb.org/do/serve?objId=PA268&objCls=Gene
Phobius	swissprot:MDR3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MDR3_HUMAN
PhylomeDB	P21439	http://phylomedb.org/?seqid=P21439
ProteinModelPortal	P21439	http://www.proteinmodelportal.org/query/uniprot/P21439
PubMed	10767346	http://www.ncbi.nlm.nih.gov/pubmed/10767346
PubMed	11313315	http://www.ncbi.nlm.nih.gov/pubmed/11313315
PubMed	11313316	http://www.ncbi.nlm.nih.gov/pubmed/11313316
PubMed	12671900	http://www.ncbi.nlm.nih.gov/pubmed/12671900
PubMed	12690205	http://www.ncbi.nlm.nih.gov/pubmed/12690205
PubMed	12746424	http://www.ncbi.nlm.nih.gov/pubmed/12746424
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	12891548	http://www.ncbi.nlm.nih.gov/pubmed/12891548
PubMed	15077010	http://www.ncbi.nlm.nih.gov/pubmed/15077010
PubMed	15258199	http://www.ncbi.nlm.nih.gov/pubmed/15258199
PubMed	16763017	http://www.ncbi.nlm.nih.gov/pubmed/16763017
PubMed	17264802	http://www.ncbi.nlm.nih.gov/pubmed/17264802
PubMed	17523162	http://www.ncbi.nlm.nih.gov/pubmed/17523162
PubMed	17726488	http://www.ncbi.nlm.nih.gov/pubmed/17726488
PubMed	19261551	http://www.ncbi.nlm.nih.gov/pubmed/19261551
PubMed	19674157	http://www.ncbi.nlm.nih.gov/pubmed/19674157
PubMed	2002063	http://www.ncbi.nlm.nih.gov/pubmed/2002063
PubMed	21119540	http://www.ncbi.nlm.nih.gov/pubmed/21119540
PubMed	21820390	http://www.ncbi.nlm.nih.gov/pubmed/21820390
PubMed	22331132	http://www.ncbi.nlm.nih.gov/pubmed/22331132
PubMed	23468132	http://www.ncbi.nlm.nih.gov/pubmed/23468132
PubMed	23533021	http://www.ncbi.nlm.nih.gov/pubmed/23533021
PubMed	24045840	http://www.ncbi.nlm.nih.gov/pubmed/24045840
PubMed	24122873	http://www.ncbi.nlm.nih.gov/pubmed/24122873
PubMed	24594635	http://www.ncbi.nlm.nih.gov/pubmed/24594635
PubMed	24723470	http://www.ncbi.nlm.nih.gov/pubmed/24723470
PubMed	24806754	http://www.ncbi.nlm.nih.gov/pubmed/24806754
PubMed	2892668	http://www.ncbi.nlm.nih.gov/pubmed/2892668
PubMed	2906314	http://www.ncbi.nlm.nih.gov/pubmed/2906314
PubMed	7893760	http://www.ncbi.nlm.nih.gov/pubmed/7893760
PubMed	7957936	http://www.ncbi.nlm.nih.gov/pubmed/7957936
PubMed	8898203	http://www.ncbi.nlm.nih.gov/pubmed/8898203
PubMed	9366571	http://www.ncbi.nlm.nih.gov/pubmed/9366571
PubMed	9419367	http://www.ncbi.nlm.nih.gov/pubmed/9419367
Reactome	R-HSA-1989781	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1989781
Reactome	R-HSA-382556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-382556
RefSeq	NP_000434	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000434
RefSeq	NP_061337	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061337
RefSeq	NP_061338	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061338
RefSeq	XP_011514615	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011514615
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	P21439	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21439
STRING	9606.ENSP00000265723	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000265723&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
SUPFAM	SSF90123	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123
TCDB	3.A.1.201	http://www.tcdb.org/search/result.php?tc=3.A.1.201
UCSC	uc003uiv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003uiv&org=rat
UniGene	Hs.654403	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.654403
UniProtKB	MDR3_HUMAN	http://www.uniprot.org/uniprot/MDR3_HUMAN
UniProtKB-AC	P21439	http://www.uniprot.org/uniprot/P21439
charge	swissprot:MDR3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MDR3_HUMAN
eggNOG	COG1132	http://eggnogapi.embl.de/nog_data/html/tree/COG1132
eggNOG	KOG0055	http://eggnogapi.embl.de/nog_data/html/tree/KOG0055
epestfind	swissprot:MDR3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MDR3_HUMAN
garnier	swissprot:MDR3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MDR3_HUMAN
helixturnhelix	swissprot:MDR3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MDR3_HUMAN
hmoment	swissprot:MDR3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MDR3_HUMAN
iep	swissprot:MDR3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MDR3_HUMAN
inforesidue	swissprot:MDR3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MDR3_HUMAN
neXtProt	NX_P21439	http://www.nextprot.org/db/entry/NX_P21439
octanol	swissprot:MDR3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MDR3_HUMAN
pepcoil	swissprot:MDR3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MDR3_HUMAN
pepdigest	swissprot:MDR3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MDR3_HUMAN
pepinfo	swissprot:MDR3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MDR3_HUMAN
pepnet	swissprot:MDR3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MDR3_HUMAN
pepstats	swissprot:MDR3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MDR3_HUMAN
pepwheel	swissprot:MDR3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MDR3_HUMAN
pepwindow	swissprot:MDR3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MDR3_HUMAN
sigcleave	swissprot:MDR3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MDR3_HUMAN
## Database	ID	URL or Descriptions
# AltName	MPC1_HUMAN	Brain protein 44-like protein
# DISEASE	MPC1_HUMAN	Mitochondrial pyruvate carrier deficiency (MPYCD) [MIM 614741]  An autosomal recessive metabolic disorder characterized by severely delayed psychomotor development, mild dysmorphic features, hepatomegaly, marked metabolic acidosis, hyperlactacidemia with normal lactate/pyruvate, and encephalopathy. Some patients have epilepsy and peripheral neuropathy. {ECO 0000269|PubMed 22628558}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000360961	ENSP00000354223; ENSG00000060762
# ExpressionAtlas	Q9Y5U8	baseline and differential
# FUNCTION	MPC1_HUMAN	Mediates the uptake of pyruvate into mitochondria. {ECO 0000269|PubMed 22628558}. 
# GO_component	GO:0005739	mitochondrion; IDA:HPA.
# GO_component	GO:0005743	mitochondrial inner membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0050833	pyruvate transmembrane transporter activity; IEA:Ensembl.
# GO_process	GO:0061732	mitochondrial acetyl-CoA biosynthetic process from pyruvate; IEA:Ensembl.
# GO_process	GO:1902361	mitochondrial pyruvate transmembrane transport; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006790	sulfur compound metabolic process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0051186	cofactor metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9Y5U8	HS
# HGNC	HGNC:21606	MPC1
# IntAct	Q9Y5U8	3
# InterPro	IPR005336	MPC
# MIM	614738	gene
# MIM	614741	phenotype
# Organism	MPC1_HUMAN	Homo sapiens (Human)
# Pfam	PF03650	MPC
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-70268	Pyruvate metabolism
# RecName	MPC1_HUMAN	Mitochondrial pyruvate carrier 1
# RefSeq	NP_057182	NM_016098.3
# SEQUENCE CAUTION	Sequence=AAG23822.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	MPC1_HUMAN	Mitochondrion inner membrane {ECO 0000269|PubMed 22628558}; Multi-pass membrane protein {ECO 0000269|PubMed 22628558}. 
# SUBUNIT	The functional 150 kDa pyruvate import complex is a heteromer of MPC1 and MPC2. {ECO:0000250|UniProtKB	P63030}. 
# TCDB	2.A.105.1	the mitochondrial pyruvate carrier (mpc) family
# UCSC	uc063svb	human
# eggNOG	ENOG4111TU9	LUCA
# eggNOG	KOG1590	Eukaryota
BLAST	swissprot:MPC1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MPC1_HUMAN
BioCyc	ZFISH:ENSG00000060762-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000060762-MONOMER
COXPRESdb	51660	http://coxpresdb.jp/data/gene/51660.shtml
CleanEx	HS_BRP44L	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_BRP44L
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.10.5.703	http://dx.doi.org/10.1101/gr.10.5.703
DOI	10.1101/gr.140200	http://dx.doi.org/10.1101/gr.140200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1218099	http://dx.doi.org/10.1126/science.1218099
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF125101	http://www.ebi.ac.uk/ena/data/view/AF125101
EMBL	AF151887	http://www.ebi.ac.uk/ena/data/view/AF151887
EMBL	AF275811	http://www.ebi.ac.uk/ena/data/view/AF275811
EMBL	AK312201	http://www.ebi.ac.uk/ena/data/view/AK312201
EMBL	AL022069	http://www.ebi.ac.uk/ena/data/view/AL022069
EMBL	BC000810	http://www.ebi.ac.uk/ena/data/view/BC000810
Ensembl	ENST00000360961	http://www.ensembl.org/id/ENST00000360961
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0050833	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050833
GO_process	GO:0061732	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061732
GO_process	GO:1902361	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902361
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0051186	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	MPC1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=MPC1
GeneID	51660	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51660
GeneTree	ENSGT00510000046988	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00510000046988
HGNC	HGNC:21606	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:21606
HOGENOM	HOG000188911	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000188911&db=HOGENOM6
HOVERGEN	HBG050728	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050728&db=HOVERGEN
HPA	HPA045119	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA045119
HPA	HPA055790	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA055790
InParanoid	Q9Y5U8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y5U8
IntAct	Q9Y5U8	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9Y5U8*
InterPro	IPR005336	http://www.ebi.ac.uk/interpro/entry/IPR005336
Jabion	51660	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=51660
KEGG_Gene	hsa:51660	http://www.genome.jp/dbget-bin/www_bget?hsa:51660
MIM	614738	http://www.ncbi.nlm.nih.gov/omim/614738
MIM	614741	http://www.ncbi.nlm.nih.gov/omim/614741
OMA	CHFANET	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CHFANET
PSORT	swissprot:MPC1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MPC1_HUMAN
PSORT-B	swissprot:MPC1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MPC1_HUMAN
PSORT2	swissprot:MPC1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MPC1_HUMAN
Pfam	PF03650	http://pfam.xfam.org/family/PF03650
PharmGKB	PA134940737	http://www.pharmgkb.org/do/serve?objId=PA134940737&objCls=Gene
Phobius	swissprot:MPC1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MPC1_HUMAN
PhylomeDB	Q9Y5U8	http://phylomedb.org/?seqid=Q9Y5U8
ProteinModelPortal	Q9Y5U8	http://www.proteinmodelportal.org/query/uniprot/Q9Y5U8
PubMed	10810093	http://www.ncbi.nlm.nih.gov/pubmed/10810093
PubMed	11042152	http://www.ncbi.nlm.nih.gov/pubmed/11042152
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22628558	http://www.ncbi.nlm.nih.gov/pubmed/22628558
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-70268	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-70268
RefSeq	NP_057182	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_057182
STRING	9606.ENSP00000354223	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000354223&targetmode=cogs
TCDB	2.A.105.1	http://www.tcdb.org/search/result.php?tc=2.A.105.1
UCSC	uc063svb	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc063svb&org=rat
UniGene	Hs.172755	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.172755
UniProtKB	MPC1_HUMAN	http://www.uniprot.org/uniprot/MPC1_HUMAN
UniProtKB-AC	Q9Y5U8	http://www.uniprot.org/uniprot/Q9Y5U8
charge	swissprot:MPC1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MPC1_HUMAN
eggNOG	ENOG4111TU9	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111TU9
eggNOG	KOG1590	http://eggnogapi.embl.de/nog_data/html/tree/KOG1590
epestfind	swissprot:MPC1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MPC1_HUMAN
garnier	swissprot:MPC1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MPC1_HUMAN
helixturnhelix	swissprot:MPC1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MPC1_HUMAN
hmoment	swissprot:MPC1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MPC1_HUMAN
iep	swissprot:MPC1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MPC1_HUMAN
inforesidue	swissprot:MPC1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MPC1_HUMAN
neXtProt	NX_Q9Y5U8	http://www.nextprot.org/db/entry/NX_Q9Y5U8
octanol	swissprot:MPC1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MPC1_HUMAN
pepcoil	swissprot:MPC1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MPC1_HUMAN
pepdigest	swissprot:MPC1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MPC1_HUMAN
pepinfo	swissprot:MPC1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MPC1_HUMAN
pepnet	swissprot:MPC1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MPC1_HUMAN
pepstats	swissprot:MPC1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MPC1_HUMAN
pepwheel	swissprot:MPC1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MPC1_HUMAN
pepwindow	swissprot:MPC1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MPC1_HUMAN
sigcleave	swissprot:MPC1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MPC1_HUMAN
## Database	ID	URL or Descriptions
# AltName	TRFE_HUMAN	Beta-1 metal-binding globulin
# AltName	TRFE_HUMAN	Siderophilin
# BioGrid	112876	38
# ChiTaRS	TF	human
# DISEASE	TRFE_HUMAN	Atransferrinemia (ATRAF) [MIM 209300]  A rare autosomal recessive disorder characterized by abnormal synthesis of transferrin leading to iron overload and microcytic hypochromic anemia. {ECO 0000269|PubMed 11110675, ECO 0000269|PubMed 15466165}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00893	Iron Dextran
# DrugBank	DB01294	Bismuth Subsalicylate
# DrugBank	DB01370	Aluminium
# DrugBank	DB05260	Gallium nitrate
# Ensembl	ENST00000402696	ENSP00000385834; ENSG00000091513
# ExpressionAtlas	P02787	baseline and differential
# FUNCTION	TRFE_HUMAN	Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. 
# GO_component	GO:0005576	extracellular region; NAS:UniProtKB.
# GO_component	GO:0005615	extracellular space; IDA:UniProtKB.
# GO_component	GO:0005769	early endosome; IDA:UniProtKB.
# GO_component	GO:0005770	late endosome; IDA:UniProtKB.
# GO_component	GO:0005905	clathrin-coated pit; IDA:UniProtKB.
# GO_component	GO:0009925	basal plasma membrane; IDA:UniProtKB.
# GO_component	GO:0009986	cell surface; IDA:UniProtKB.
# GO_component	GO:0010008	endosome membrane; TAS:Reactome.
# GO_component	GO:0016023	cytoplasmic, membrane-bounded vesicle; IDA:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_component	GO:0030139	endocytic vesicle; IDA:MGI.
# GO_component	GO:0031232	extrinsic component of external side of plasma membrane; IGI:BHF-UCL.
# GO_component	GO:0031982	vesicle; IDA:UniProtKB.
# GO_component	GO:0034774	secretory granule lumen; TAS:Reactome.
# GO_component	GO:0045178	basal part of cell; IDA:UniProtKB.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IDA:UniProtKB.
# GO_component	GO:0055037	recycling endosome; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_component	GO:0072562	blood microparticle; IDA:UniProtKB.
# GO_component	GO:1990712	HFE-transferrin receptor complex; IDA:BHF-UCL.
# GO_function	GO:0008198	ferrous iron binding; IDA:BHF-UCL.
# GO_function	GO:0008199	ferric iron binding; IEA:InterPro.
# GO_function	GO:0015091	ferric iron transmembrane transporter activity; IEA:InterPro.
# GO_function	GO:1990459	transferrin receptor binding; IPI:BHF-UCL.
# GO_process	GO:0001895	retina homeostasis; IEP:UniProtKB.
# GO_process	GO:0002576	platelet degranulation; TAS:Reactome.
# GO_process	GO:0006879	cellular iron ion homeostasis; TAS:Reactome.
# GO_process	GO:0031647	regulation of protein stability; TAS:BHF-UCL.
# GO_process	GO:0033572	transferrin transport; TAS:Reactome.
# GO_process	GO:0048260	positive regulation of receptor-mediated endocytosis; IDA:BHF-UCL.
# GO_process	GO:0055072	iron ion homeostasis; IC:BHF-UCL.
# GO_process	GO:0071281	cellular response to iron ion; IGI:BHF-UCL.
# GO_process	GO:0097460	ferrous iron import into cell; IGI:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005576	extracellular region
# GOslim_component	GO:0005615	extracellular space
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0042592	homeostatic process
# Genevisible	P02787	HS
# HGNC	HGNC:11740	TF
# INTERACTION	TRFE_HUMAN	P01350 GAST; NbExp=5; IntAct=EBI-714319, EBI-3436637; 
# IntAct	P02787	33
# InterPro	IPR001156	Transferrin-like_dom
# InterPro	IPR016357	Transferrin
# InterPro	IPR018195	Transferrin_Fe_BS
# InterPro	IPR030685	Serotransferrin_mammal
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Disease	H01145	[Inherited metabolic disease; Hematologic disease] Congenital hypotransferrinemia
# KEGG_Pathway	ko04066	HIF-1 signaling pathway
# KEGG_Pathway	ko04978	Mineral absorption
# MIM	190000	gene
# MIM	209300	phenotype
# Organism	TRFE_HUMAN	Homo sapiens (Human)
# Orphanet	1195	Congenital atransferrinemia
# PDB	1A8E	X-ray; 1.60 A; A=22-350
# PDB	1A8F	X-ray; 1.80 A; A=22-350
# PDB	1B3E	X-ray; 2.50 A; A=23-352
# PDB	1BP5	X-ray; 2.20 A; A/B/C/D=20-356
# PDB	1BTJ	X-ray; 3.20 A; A/B=20-356
# PDB	1D3K	X-ray; 1.80 A; A=22-350
# PDB	1D4N	X-ray; 2.00 A; A=22-350
# PDB	1DTG	X-ray; 2.40 A; A=20-353
# PDB	1FQE	X-ray; 1.80 A; A=20-350
# PDB	1FQF	X-ray; 2.10 A; A=20-350
# PDB	1JQF	X-ray; 1.85 A; A=20-353
# PDB	1N7W	X-ray; 2.20 A; A=22-350
# PDB	1N7X	X-ray; 2.10 A; A=20-350
# PDB	1N84	X-ray; 2.05 A; A=20-350
# PDB	1OQG	X-ray; 1.90 A; A=20-354
# PDB	1OQH	X-ray; 2.40 A; A=20-354
# PDB	1RYO	X-ray; 1.20 A; A=20-346
# PDB	1SUV	EM; 7.50 A; C/D=22-350
# PDB	2HAU	X-ray; 2.70 A; A/B=23-698
# PDB	2HAV	X-ray; 2.70 A; A/B=23-698
# PDB	2O7U	X-ray; 2.80 A; A/B/C/D/E/F/G/H/I=20-356
# PDB	2O84	X-ray; 2.60 A; X=20-356
# PDB	3FGS	X-ray; 1.80 A; A=20-356
# PDB	3QYT	X-ray; 2.80 A; A=20-698
# PDB	3S9L	X-ray; 3.22 A; C/D=20-698
# PDB	3S9M	X-ray; 3.32 A; C/D=20-698
# PDB	3S9N	X-ray; 3.25 A; C/D=20-698
# PDB	3SKP	X-ray; 1.70 A; A=358-698
# PDB	3V83	X-ray; 2.10 A; A/B/C/D/E/F=1-698
# PDB	3V89	X-ray; 3.10 A; B=356-698
# PDB	3V8X	X-ray; 2.60 A; B=1-698
# PDB	3VE1	X-ray; 2.96 A; B/D=20-698
# PDB	4H0W	X-ray; 2.40 A; A=20-698
# PDB	4X1B	X-ray; 2.45 A; A=20-698
# PDB	4X1D	X-ray; 2.80 A; A/B=20-698
# PDB	5DYH	X-ray; 2.68 A; A/B=1-698
# PIR	A20981	TFHUP
# PIRSF	PIRSF002549	Transferrin
# PIRSF	PIRSF500682	Serotransferrin
# POLYMORPHISM	TRFE_HUMAN	Different polymorphic variants of transferrin are known. The sequence shown is the predominant electrophoretic variant (C1 or TF*C1). 
# PRINTS	PR00422	TRANSFERRIN
# PROSITE	PS00205	TRANSFERRIN_LIKE_1
# PROSITE	PS00206	TRANSFERRIN_LIKE_2; 2
# PROSITE	PS00207	TRANSFERRIN_LIKE_3; 2
# PROSITE	PS51408	TRANSFERRIN_LIKE_4; 2
# Pfam	PF00405	Transferrin; 2
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-114608	Platelet degranulation
# Reactome	R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis
# Reactome	R-HSA-8856828	Clathrin-mediated endocytosis
# Reactome	R-HSA-917937	Iron uptake and transport
# Reactome	R-HSA-917977	Transferrin endocytosis and recycling
# RecName	TRFE_HUMAN	Serotransferrin
# RefSeq	NP_001054	NM_001063.3
# RefSeq	XP_016862578	XM_017007089.1
# RefSeq	XP_016862579	XM_017007090.1
# SEQUENCE CAUTION	Sequence=AAF22007.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the transferrin family. {ECO:0000255|PROSITE-ProRule	PRU00741}. 
# SIMILARITY	Contains 2 transferrin-like domains. {ECO:0000255|PROSITE-ProRule	PRU00741}. 
# SMART	SM00094	TR_FER; 2
# SUBCELLULAR LOCATION	TRFE_HUMAN	Secreted. 
# SUBUNIT	TRFE_HUMAN	Monomer. 
# TISSUE SPECIFICITY	TRFE_HUMAN	Expressed by the liver and secreted in plasma. 
# UCSC	uc003epv	human
# WEB RESOURCE	TRFE_HUMAN	Name=SeattleSNPs; URL="http //pga.gs.washington.edu/data/tf/";
# WEB RESOURCE	TRFE_HUMAN	Name=Wikipedia; Note=Transferrin entry; URL="https //en.wikipedia.org/wiki/Transferrin"; 
# eggNOG	ENOG410IEAI	Eukaryota
# eggNOG	ENOG410XQ36	LUCA
BLAST	swissprot:TRFE_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TRFE_HUMAN
BioCyc	ZFISH:ENSG00000091513-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000091513-MONOMER
COXPRESdb	7018	http://coxpresdb.jp/data/gene/7018.shtml
CleanEx	HS_TF	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TF
DIP	DIP-2738N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-2738N
DOI	10.1002/1097-4547(20000815)61:4<388::AID-JNR5>3.0.CO	http://dx.doi.org/10.1002/1097-4547(20000815)61:4<388::AID-JNR5>3.0.CO
DOI	10.1002/elps.11501601192	http://dx.doi.org/10.1002/elps.11501601192
DOI	10.1002/pmic.200300556	http://dx.doi.org/10.1002/pmic.200300556
DOI	10.1002/rcm.1718	http://dx.doi.org/10.1002/rcm.1718
DOI	10.1007/s004390050533	http://dx.doi.org/10.1007/s004390050533
DOI	10.1007/s004390100599	http://dx.doi.org/10.1007/s004390100599
DOI	10.1016/0006-291X(84)91648-6	http://dx.doi.org/10.1016/0006-291X(84)91648-6
DOI	10.1016/0378-1119(86)90277-5	http://dx.doi.org/10.1016/0378-1119(86)90277-5
DOI	10.1016/0378-1119(87)90163-6	http://dx.doi.org/10.1016/0378-1119(87)90163-6
DOI	10.1016/S0378-1119(97)00356-9	http://dx.doi.org/10.1016/S0378-1119(97)00356-9
DOI	10.1016/j.cell.2015.05.028	http://dx.doi.org/10.1016/j.cell.2015.05.028
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/bi00109a002	http://dx.doi.org/10.1021/bi00109a002
DOI	10.1021/bi980355j	http://dx.doi.org/10.1021/bi980355j
DOI	10.1021/bi9812064	http://dx.doi.org/10.1021/bi9812064
DOI	10.1021/bi9824543	http://dx.doi.org/10.1021/bi9824543
DOI	10.1021/pr0502065	http://dx.doi.org/10.1021/pr0502065
DOI	10.1021/pr050492k	http://dx.doi.org/10.1021/pr050492k
DOI	10.1021/pr300539b	http://dx.doi.org/10.1021/pr300539b
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1038/nmeth.1392	http://dx.doi.org/10.1038/nmeth.1392
DOI	10.1046/j.1365-2141.2001.03096.x	http://dx.doi.org/10.1046/j.1365-2141.2001.03096.x
DOI	10.1046/j.1469-1809.1998.6230271.x	http://dx.doi.org/10.1046/j.1469-1809.1998.6230271.x
DOI	10.1073/pnas.79.8.2504	http://dx.doi.org/10.1073/pnas.79.8.2504
DOI	10.1073/pnas.81.9.2752	http://dx.doi.org/10.1073/pnas.81.9.2752
DOI	10.1073/pnas.82.10.3149	http://dx.doi.org/10.1073/pnas.82.10.3149
DOI	10.1073/pnas.86.18.7260	http://dx.doi.org/10.1073/pnas.86.18.7260
DOI	10.1074/mcp.M400015-MCP200	http://dx.doi.org/10.1074/mcp.M400015-MCP200
DOI	10.1074/mcp.M800504-MCP200	http://dx.doi.org/10.1074/mcp.M800504-MCP200
DOI	10.1093/nar/14.21.8692	http://dx.doi.org/10.1093/nar/14.21.8692
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1749-6632.1991.tb18573.x	http://dx.doi.org/10.1111/j.1749-6632.1991.tb18573.x
DOI	10.1182/blood-2004-05-1751	http://dx.doi.org/10.1182/blood-2004-05-1751
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DrugBank	DB00893	http://www.drugbank.ca/drugs/DB00893
DrugBank	DB01294	http://www.drugbank.ca/drugs/DB01294
DrugBank	DB01370	http://www.drugbank.ca/drugs/DB01370
DrugBank	DB05260	http://www.drugbank.ca/drugs/DB05260
EMBL	AC080128	http://www.ebi.ac.uk/ena/data/view/AC080128
EMBL	AC083905	http://www.ebi.ac.uk/ena/data/view/AC083905
EMBL	AF058327	http://www.ebi.ac.uk/ena/data/view/AF058327
EMBL	AF118063	http://www.ebi.ac.uk/ena/data/view/AF118063
EMBL	AF288139	http://www.ebi.ac.uk/ena/data/view/AF288139
EMBL	AF288140	http://www.ebi.ac.uk/ena/data/view/AF288140
EMBL	AF288141	http://www.ebi.ac.uk/ena/data/view/AF288141
EMBL	AF288142	http://www.ebi.ac.uk/ena/data/view/AF288142
EMBL	AF288143	http://www.ebi.ac.uk/ena/data/view/AF288143
EMBL	AF288144	http://www.ebi.ac.uk/ena/data/view/AF288144
EMBL	AF294270	http://www.ebi.ac.uk/ena/data/view/AF294270
EMBL	AF294271	http://www.ebi.ac.uk/ena/data/view/AF294271
EMBL	AJ252279	http://www.ebi.ac.uk/ena/data/view/AJ252279
EMBL	AY308797	http://www.ebi.ac.uk/ena/data/view/AY308797
EMBL	BC059367	http://www.ebi.ac.uk/ena/data/view/BC059367
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
EMBL	DQ525716	http://www.ebi.ac.uk/ena/data/view/DQ525716
EMBL	M11361	http://www.ebi.ac.uk/ena/data/view/M11361
EMBL	M11362	http://www.ebi.ac.uk/ena/data/view/M11362
EMBL	M11363	http://www.ebi.ac.uk/ena/data/view/M11363
EMBL	M11364	http://www.ebi.ac.uk/ena/data/view/M11364
EMBL	M11365	http://www.ebi.ac.uk/ena/data/view/M11365
EMBL	M11366	http://www.ebi.ac.uk/ena/data/view/M11366
EMBL	M11367	http://www.ebi.ac.uk/ena/data/view/M11367
EMBL	M11368	http://www.ebi.ac.uk/ena/data/view/M11368
EMBL	M11369	http://www.ebi.ac.uk/ena/data/view/M11369
EMBL	M11370	http://www.ebi.ac.uk/ena/data/view/M11370
EMBL	M11371	http://www.ebi.ac.uk/ena/data/view/M11371
EMBL	M11372	http://www.ebi.ac.uk/ena/data/view/M11372
EMBL	M12525	http://www.ebi.ac.uk/ena/data/view/M12525
EMBL	M12530	http://www.ebi.ac.uk/ena/data/view/M12530
EMBL	M15673	http://www.ebi.ac.uk/ena/data/view/M15673
EMBL	M17610	http://www.ebi.ac.uk/ena/data/view/M17610
EMBL	M17611	http://www.ebi.ac.uk/ena/data/view/M17611
EMBL	M17612	http://www.ebi.ac.uk/ena/data/view/M17612
EMBL	M17613	http://www.ebi.ac.uk/ena/data/view/M17613
EMBL	M17614	http://www.ebi.ac.uk/ena/data/view/M17614
EMBL	M21569	http://www.ebi.ac.uk/ena/data/view/M21569
EMBL	M21570	http://www.ebi.ac.uk/ena/data/view/M21570
EMBL	M26641	http://www.ebi.ac.uk/ena/data/view/M26641
EMBL	S95936	http://www.ebi.ac.uk/ena/data/view/S95936
EMBL	U88581	http://www.ebi.ac.uk/ena/data/view/U88581
EMBL	X04600	http://www.ebi.ac.uk/ena/data/view/X04600
Ensembl	ENST00000402696	http://www.ensembl.org/id/ENST00000402696
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005576	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576
GO_component	GO:0005615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005615
GO_component	GO:0005769	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005769
GO_component	GO:0005770	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005770
GO_component	GO:0005905	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005905
GO_component	GO:0009925	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009925
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0010008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010008
GO_component	GO:0016023	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016023
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0030139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030139
GO_component	GO:0031232	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031232
GO_component	GO:0031982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031982
GO_component	GO:0034774	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034774
GO_component	GO:0045178	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045178
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_component	GO:0055037	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055037
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_component	GO:0072562	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072562
GO_component	GO:1990712	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990712
GO_function	GO:0008198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008198
GO_function	GO:0008199	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008199
GO_function	GO:0015091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015091
GO_function	GO:1990459	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990459
GO_process	GO:0001895	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001895
GO_process	GO:0002576	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002576
GO_process	GO:0006879	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006879
GO_process	GO:0031647	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031647
GO_process	GO:0033572	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033572
GO_process	GO:0048260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048260
GO_process	GO:0055072	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072
GO_process	GO:0071281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071281
GO_process	GO:0097460	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097460
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005576	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576
GOslim_component	GO:0005615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005615
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GeneCards	TF	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TF
GeneID	7018	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7018
GeneTree	ENSGT00390000001619	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000001619
HGNC	HGNC:11740	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11740
HOGENOM	HOG000252723	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000252723&db=HOGENOM6
HOVERGEN	HBG000055	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000055&db=HOVERGEN
HPA	CAB009538	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB009538
HPA	HPA001527	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA001527
HPA	HPA005692	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA005692
InParanoid	P02787	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P02787
IntAct	P02787	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P02787*
InterPro	IPR001156	http://www.ebi.ac.uk/interpro/entry/IPR001156
InterPro	IPR016357	http://www.ebi.ac.uk/interpro/entry/IPR016357
InterPro	IPR018195	http://www.ebi.ac.uk/interpro/entry/IPR018195
InterPro	IPR030685	http://www.ebi.ac.uk/interpro/entry/IPR030685
Jabion	7018	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7018
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Disease	H01145	http://www.genome.jp/dbget-bin/www_bget?H01145
KEGG_Gene	hsa:7018	http://www.genome.jp/dbget-bin/www_bget?hsa:7018
KEGG_Orthology	KO:K14736	http://www.genome.jp/dbget-bin/www_bget?KO:K14736
KEGG_Pathway	ko04066	http://www.genome.jp/kegg-bin/show_pathway?ko04066
KEGG_Pathway	ko04978	http://www.genome.jp/kegg-bin/show_pathway?ko04978
MIM	190000	http://www.ncbi.nlm.nih.gov/omim/190000
MIM	209300	http://www.ncbi.nlm.nih.gov/omim/209300
MINT	MINT-1400694	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1400694
OMA	IGLLYCD	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IGLLYCD
Orphanet	1195	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1195
OrthoDB	EOG091G0242	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0242
PDB	1A8E	http://www.ebi.ac.uk/pdbe-srv/view/entry/1A8E
PDB	1A8F	http://www.ebi.ac.uk/pdbe-srv/view/entry/1A8F
PDB	1B3E	http://www.ebi.ac.uk/pdbe-srv/view/entry/1B3E
PDB	1BP5	http://www.ebi.ac.uk/pdbe-srv/view/entry/1BP5
PDB	1BTJ	http://www.ebi.ac.uk/pdbe-srv/view/entry/1BTJ
PDB	1D3K	http://www.ebi.ac.uk/pdbe-srv/view/entry/1D3K
PDB	1D4N	http://www.ebi.ac.uk/pdbe-srv/view/entry/1D4N
PDB	1DTG	http://www.ebi.ac.uk/pdbe-srv/view/entry/1DTG
PDB	1FQE	http://www.ebi.ac.uk/pdbe-srv/view/entry/1FQE
PDB	1FQF	http://www.ebi.ac.uk/pdbe-srv/view/entry/1FQF
PDB	1JQF	http://www.ebi.ac.uk/pdbe-srv/view/entry/1JQF
PDB	1N7W	http://www.ebi.ac.uk/pdbe-srv/view/entry/1N7W
PDB	1N7X	http://www.ebi.ac.uk/pdbe-srv/view/entry/1N7X
PDB	1N84	http://www.ebi.ac.uk/pdbe-srv/view/entry/1N84
PDB	1OQG	http://www.ebi.ac.uk/pdbe-srv/view/entry/1OQG
PDB	1OQH	http://www.ebi.ac.uk/pdbe-srv/view/entry/1OQH
PDB	1RYO	http://www.ebi.ac.uk/pdbe-srv/view/entry/1RYO
PDB	1SUV	http://www.ebi.ac.uk/pdbe-srv/view/entry/1SUV
PDB	2HAU	http://www.ebi.ac.uk/pdbe-srv/view/entry/2HAU
PDB	2HAV	http://www.ebi.ac.uk/pdbe-srv/view/entry/2HAV
PDB	2O7U	http://www.ebi.ac.uk/pdbe-srv/view/entry/2O7U
PDB	2O84	http://www.ebi.ac.uk/pdbe-srv/view/entry/2O84
PDB	3FGS	http://www.ebi.ac.uk/pdbe-srv/view/entry/3FGS
PDB	3QYT	http://www.ebi.ac.uk/pdbe-srv/view/entry/3QYT
PDB	3S9L	http://www.ebi.ac.uk/pdbe-srv/view/entry/3S9L
PDB	3S9M	http://www.ebi.ac.uk/pdbe-srv/view/entry/3S9M
PDB	3S9N	http://www.ebi.ac.uk/pdbe-srv/view/entry/3S9N
PDB	3SKP	http://www.ebi.ac.uk/pdbe-srv/view/entry/3SKP
PDB	3V83	http://www.ebi.ac.uk/pdbe-srv/view/entry/3V83
PDB	3V89	http://www.ebi.ac.uk/pdbe-srv/view/entry/3V89
PDB	3V8X	http://www.ebi.ac.uk/pdbe-srv/view/entry/3V8X
PDB	3VE1	http://www.ebi.ac.uk/pdbe-srv/view/entry/3VE1
PDB	4H0W	http://www.ebi.ac.uk/pdbe-srv/view/entry/4H0W
PDB	4X1B	http://www.ebi.ac.uk/pdbe-srv/view/entry/4X1B
PDB	4X1D	http://www.ebi.ac.uk/pdbe-srv/view/entry/4X1D
PDB	5DYH	http://www.ebi.ac.uk/pdbe-srv/view/entry/5DYH
PDBsum	1A8E	http://www.ebi.ac.uk/pdbsum/1A8E
PDBsum	1A8F	http://www.ebi.ac.uk/pdbsum/1A8F
PDBsum	1B3E	http://www.ebi.ac.uk/pdbsum/1B3E
PDBsum	1BP5	http://www.ebi.ac.uk/pdbsum/1BP5
PDBsum	1BTJ	http://www.ebi.ac.uk/pdbsum/1BTJ
PDBsum	1D3K	http://www.ebi.ac.uk/pdbsum/1D3K
PDBsum	1D4N	http://www.ebi.ac.uk/pdbsum/1D4N
PDBsum	1DTG	http://www.ebi.ac.uk/pdbsum/1DTG
PDBsum	1FQE	http://www.ebi.ac.uk/pdbsum/1FQE
PDBsum	1FQF	http://www.ebi.ac.uk/pdbsum/1FQF
PDBsum	1JQF	http://www.ebi.ac.uk/pdbsum/1JQF
PDBsum	1N7W	http://www.ebi.ac.uk/pdbsum/1N7W
PDBsum	1N7X	http://www.ebi.ac.uk/pdbsum/1N7X
PDBsum	1N84	http://www.ebi.ac.uk/pdbsum/1N84
PDBsum	1OQG	http://www.ebi.ac.uk/pdbsum/1OQG
PDBsum	1OQH	http://www.ebi.ac.uk/pdbsum/1OQH
PDBsum	1RYO	http://www.ebi.ac.uk/pdbsum/1RYO
PDBsum	1SUV	http://www.ebi.ac.uk/pdbsum/1SUV
PDBsum	2HAU	http://www.ebi.ac.uk/pdbsum/2HAU
PDBsum	2HAV	http://www.ebi.ac.uk/pdbsum/2HAV
PDBsum	2O7U	http://www.ebi.ac.uk/pdbsum/2O7U
PDBsum	2O84	http://www.ebi.ac.uk/pdbsum/2O84
PDBsum	3FGS	http://www.ebi.ac.uk/pdbsum/3FGS
PDBsum	3QYT	http://www.ebi.ac.uk/pdbsum/3QYT
PDBsum	3S9L	http://www.ebi.ac.uk/pdbsum/3S9L
PDBsum	3S9M	http://www.ebi.ac.uk/pdbsum/3S9M
PDBsum	3S9N	http://www.ebi.ac.uk/pdbsum/3S9N
PDBsum	3SKP	http://www.ebi.ac.uk/pdbsum/3SKP
PDBsum	3V83	http://www.ebi.ac.uk/pdbsum/3V83
PDBsum	3V89	http://www.ebi.ac.uk/pdbsum/3V89
PDBsum	3V8X	http://www.ebi.ac.uk/pdbsum/3V8X
PDBsum	3VE1	http://www.ebi.ac.uk/pdbsum/3VE1
PDBsum	4H0W	http://www.ebi.ac.uk/pdbsum/4H0W
PDBsum	4X1B	http://www.ebi.ac.uk/pdbsum/4X1B
PDBsum	4X1D	http://www.ebi.ac.uk/pdbsum/4X1D
PDBsum	5DYH	http://www.ebi.ac.uk/pdbsum/5DYH
PRINTS	PR00422	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00422
PROSITE	PS00205	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00205
PROSITE	PS00206	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00206
PROSITE	PS00207	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00207
PROSITE	PS51408	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51408
PSORT	swissprot:TRFE_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TRFE_HUMAN
PSORT-B	swissprot:TRFE_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TRFE_HUMAN
PSORT2	swissprot:TRFE_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TRFE_HUMAN
Pfam	PF00405	http://pfam.xfam.org/family/PF00405
PharmGKB	PA36457	http://www.pharmgkb.org/do/serve?objId=PA36457&objCls=Gene
Phobius	swissprot:TRFE_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TRFE_HUMAN
PhylomeDB	P02787	http://phylomedb.org/?seqid=P02787
ProteinModelPortal	P02787	http://www.proteinmodelportal.org/query/uniprot/P02787
PubMed	10029548	http://www.ncbi.nlm.nih.gov/pubmed/10029548
PubMed	10931525	http://www.ncbi.nlm.nih.gov/pubmed/10931525
PubMed	11110675	http://www.ncbi.nlm.nih.gov/pubmed/11110675
PubMed	11702220	http://www.ncbi.nlm.nih.gov/pubmed/11702220
PubMed	11703331	http://www.ncbi.nlm.nih.gov/pubmed/11703331
PubMed	14760718	http://www.ncbi.nlm.nih.gov/pubmed/14760718
PubMed	15084671	http://www.ncbi.nlm.nih.gov/pubmed/15084671
PubMed	15466165	http://www.ncbi.nlm.nih.gov/pubmed/15466165
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15536627	http://www.ncbi.nlm.nih.gov/pubmed/15536627
PubMed	16335952	http://www.ncbi.nlm.nih.gov/pubmed/16335952
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	16740002	http://www.ncbi.nlm.nih.gov/pubmed/16740002
PubMed	1809186	http://www.ncbi.nlm.nih.gov/pubmed/1809186
PubMed	19139490	http://www.ncbi.nlm.nih.gov/pubmed/19139490
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	1932003	http://www.ncbi.nlm.nih.gov/pubmed/1932003
PubMed	19838169	http://www.ncbi.nlm.nih.gov/pubmed/19838169
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22905912	http://www.ncbi.nlm.nih.gov/pubmed/22905912
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	26091039	http://www.ncbi.nlm.nih.gov/pubmed/26091039
PubMed	2780570	http://www.ncbi.nlm.nih.gov/pubmed/2780570
PubMed	3106157	http://www.ncbi.nlm.nih.gov/pubmed/3106157
PubMed	3678832	http://www.ncbi.nlm.nih.gov/pubmed/3678832
PubMed	3786138	http://www.ncbi.nlm.nih.gov/pubmed/3786138
PubMed	3858812	http://www.ncbi.nlm.nih.gov/pubmed/3858812
PubMed	6322780	http://www.ncbi.nlm.nih.gov/pubmed/6322780
PubMed	6585826	http://www.ncbi.nlm.nih.gov/pubmed/6585826
PubMed	6833213	http://www.ncbi.nlm.nih.gov/pubmed/6833213
PubMed	6953407	http://www.ncbi.nlm.nih.gov/pubmed/6953407
PubMed	7498159	http://www.ncbi.nlm.nih.gov/pubmed/7498159
PubMed	9272172	http://www.ncbi.nlm.nih.gov/pubmed/9272172
PubMed	9358047	http://www.ncbi.nlm.nih.gov/pubmed/9358047
PubMed	9609685	http://www.ncbi.nlm.nih.gov/pubmed/9609685
PubMed	9760232	http://www.ncbi.nlm.nih.gov/pubmed/9760232
PubMed	9803271	http://www.ncbi.nlm.nih.gov/pubmed/9803271
Reactome	R-HSA-114608	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-114608
Reactome	R-HSA-8856825	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8856825
Reactome	R-HSA-8856828	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8856828
Reactome	R-HSA-917937	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917937
Reactome	R-HSA-917977	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917977
RefSeq	NP_001054	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001054
RefSeq	XP_016862578	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016862578
RefSeq	XP_016862579	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016862579
SMART	SM00094	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00094
SMR	P02787	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P02787
STRING	9606.ENSP00000385834	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000385834&targetmode=cogs
SWISS-2DPAGE	P02787	http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P02787
UCSC	uc003epv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003epv&org=rat
UniGene	Hs.518267	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.518267
UniProtKB	TRFE_HUMAN	http://www.uniprot.org/uniprot/TRFE_HUMAN
UniProtKB-AC	P02787	http://www.uniprot.org/uniprot/P02787
charge	swissprot:TRFE_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TRFE_HUMAN
eggNOG	ENOG410IEAI	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IEAI
eggNOG	ENOG410XQ36	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ36
epestfind	swissprot:TRFE_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TRFE_HUMAN
garnier	swissprot:TRFE_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TRFE_HUMAN
helixturnhelix	swissprot:TRFE_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRFE_HUMAN
hmoment	swissprot:TRFE_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TRFE_HUMAN
iep	swissprot:TRFE_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TRFE_HUMAN
inforesidue	swissprot:TRFE_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TRFE_HUMAN
neXtProt	NX_P02787	http://www.nextprot.org/db/entry/NX_P02787
octanol	swissprot:TRFE_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TRFE_HUMAN
pepcoil	swissprot:TRFE_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TRFE_HUMAN
pepdigest	swissprot:TRFE_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TRFE_HUMAN
pepinfo	swissprot:TRFE_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TRFE_HUMAN
pepnet	swissprot:TRFE_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TRFE_HUMAN
pepstats	swissprot:TRFE_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TRFE_HUMAN
pepwheel	swissprot:TRFE_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TRFE_HUMAN
pepwindow	swissprot:TRFE_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TRFE_HUMAN
sigcleave	swissprot:TRFE_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TRFE_HUMAN
## Database	ID	URL or Descriptions
# AltName	NMD3B_HUMAN	N-methyl-D-aspartate receptor subtype 3B
# BioGrid	125509	2
# DrugBank	DB00145	Glycine
# DrugBank	DB00289	Atomoxetine
# DrugBank	DB00312	Pentobarbital
# DrugBank	DB00418	Secobarbital
# DrugBank	DB00659	Acamprosate
# DrugBank	DB00996	Gabapentin
# DrugBank	DB01159	Halothane
# DrugBank	DB01173	Orphenadrine
# DrugBank	DB01174	Phenobarbital
# DrugBank	DB04896	Milnacipran
# DrugBank	DB06738	Ketobemidone
# Ensembl	ENST00000234389	ENSP00000234389; ENSG00000116032
# FUNCTION	NMD3B_HUMAN	NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. 
# GO_component	GO:0017146	NMDA selective glutamate receptor complex; ISS:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0043025	neuronal cell body; ISS:UniProtKB.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0004972	NMDA glutamate receptor activity; IBA:GO_Central.
# GO_function	GO:0005234	extracellular-glutamate-gated ion channel activity; IEA:InterPro.
# GO_function	GO:0005261	cation channel activity; ISS:UniProtKB.
# GO_function	GO:0005262	calcium channel activity; IEA:Ensembl.
# GO_function	GO:0016594	glycine binding; ISS:UniProtKB.
# GO_function	GO:0030594	neurotransmitter receptor activity; ISS:UniProtKB.
# GO_function	GO:0042165	neurotransmitter binding; ISS:UniProtKB.
# GO_process	GO:0035235	ionotropic glutamate receptor signaling pathway; ISS:UniProtKB.
# GO_process	GO:0051205	protein insertion into membrane; ISS:UniProtKB.
# GO_process	GO:0051924	regulation of calcium ion transport; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# Genevisible	O60391	HS
# HGNC	HGNC:16768	GRIN3B
# InterPro	IPR001320	Iontro_rcpt
# InterPro	IPR001508	Iono_rcpt_met
# InterPro	IPR019594	Glu/Gly-bd
# InterPro	IPR028082	Peripla_BP_I
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04724	Glutamatergic synapse
# KEGG_Pathway	ko05030	Cocaine addiction
# KEGG_Pathway	ko05031	Amphetamine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# KEGG_Pathway	ko05034	Alcoholism
# MIM	606651	gene
# Organism	NMD3B_HUMAN	Homo sapiens (Human)
# PRINTS	PR00177	NMDARECEPTOR
# Pfam	PF00060	Lig_chan
# Pfam	PF10613	Lig_chan-Glu_bd
# Proteomes	UP000005640	Chromosome 19
# RecName	NMD3B_HUMAN	Glutamate receptor ionotropic, NMDA 3B
# RefSeq	NP_619635	NM_138690.2
# SEQUENCE CAUTION	Sequence=AAC12680.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR3B/GRIN3B subfamily. {ECO	0000305}. 
# SMART	SM00079	PBPe
# SMART	SM00918	Lig_chan-Glu_bd
# SUBCELLULAR LOCATION	NMD3B_HUMAN	Cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO 0000250}. Note=Requires the presence of GRIN1 to be targeted at the plasma membrane. {ECO 0000250}. 
# SUBUNIT	Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex containing GRIN1 and GRIN2A (By similarity). {ECO	0000250}. 
# SUPFAM	SSF53822	SSF53822
# UCSC	uc002lqo	human
# eggNOG	ENOG410XNUR	LUCA
# eggNOG	KOG1053	Eukaryota
BLAST	swissprot:NMD3B_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NMD3B_HUMAN
BioCyc	ZFISH:ENSG00000116032-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000116032-MONOMER
COXPRESdb	116444	http://coxpresdb.jp/data/gene/116444.shtml
CleanEx	HS_GRIN3B	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GRIN3B
DOI	10.1006/geno.2001.6666	http://dx.doi.org/10.1006/geno.2001.6666
DOI	10.1016/j.neulet.2004.11.064	http://dx.doi.org/10.1016/j.neulet.2004.11.064
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DrugBank	DB00145	http://www.drugbank.ca/drugs/DB00145
DrugBank	DB00289	http://www.drugbank.ca/drugs/DB00289
DrugBank	DB00312	http://www.drugbank.ca/drugs/DB00312
DrugBank	DB00418	http://www.drugbank.ca/drugs/DB00418
DrugBank	DB00659	http://www.drugbank.ca/drugs/DB00659
DrugBank	DB00996	http://www.drugbank.ca/drugs/DB00996
DrugBank	DB01159	http://www.drugbank.ca/drugs/DB01159
DrugBank	DB01173	http://www.drugbank.ca/drugs/DB01173
DrugBank	DB01174	http://www.drugbank.ca/drugs/DB01174
DrugBank	DB04896	http://www.drugbank.ca/drugs/DB04896
DrugBank	DB06738	http://www.drugbank.ca/drugs/DB06738
EMBL	AC004528	http://www.ebi.ac.uk/ena/data/view/AC004528
EMBL	BK000070	http://www.ebi.ac.uk/ena/data/view/BK000070
EMBL	BK004079	http://www.ebi.ac.uk/ena/data/view/BK004079
Ensembl	ENST00000234389	http://www.ensembl.org/id/ENST00000234389
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0017146	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017146
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0004972	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004972
GO_function	GO:0005234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005234
GO_function	GO:0005261	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005261
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0016594	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016594
GO_function	GO:0030594	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030594
GO_function	GO:0042165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042165
GO_process	GO:0035235	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035235
GO_process	GO:0051205	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051205
GO_process	GO:0051924	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051924
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	GRIN3B	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GRIN3B
GeneID	116444	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=116444
GeneTree	ENSGT00760000119186	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119186
HGNC	HGNC:16768	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16768
HOGENOM	HOG000231528	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231528&db=HOGENOM6
HOVERGEN	HBG052634	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052634&db=HOVERGEN
HPA	CAB004269	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB004269
InParanoid	O60391	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O60391
InterPro	IPR001320	http://www.ebi.ac.uk/interpro/entry/IPR001320
InterPro	IPR001508	http://www.ebi.ac.uk/interpro/entry/IPR001508
InterPro	IPR019594	http://www.ebi.ac.uk/interpro/entry/IPR019594
InterPro	IPR028082	http://www.ebi.ac.uk/interpro/entry/IPR028082
Jabion	116444	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=116444
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:116444	http://www.genome.jp/dbget-bin/www_bget?hsa:116444
KEGG_Orthology	KO:K05214	http://www.genome.jp/dbget-bin/www_bget?KO:K05214
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
KEGG_Pathway	ko05030	http://www.genome.jp/kegg-bin/show_pathway?ko05030
KEGG_Pathway	ko05031	http://www.genome.jp/kegg-bin/show_pathway?ko05031
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
KEGG_Pathway	ko05034	http://www.genome.jp/kegg-bin/show_pathway?ko05034
MIM	606651	http://www.ncbi.nlm.nih.gov/omim/606651
MINT	MINT-6630966	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6630966
OMA	HLQLDWA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HLQLDWA
OrthoDB	EOG091G00PT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00PT
PRINTS	PR00177	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00177
PSORT	swissprot:NMD3B_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NMD3B_HUMAN
PSORT-B	swissprot:NMD3B_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NMD3B_HUMAN
PSORT2	swissprot:NMD3B_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NMD3B_HUMAN
Pfam	PF00060	http://pfam.xfam.org/family/PF00060
Pfam	PF10613	http://pfam.xfam.org/family/PF10613
PharmGKB	PA28984	http://www.pharmgkb.org/do/serve?objId=PA28984&objCls=Gene
Phobius	swissprot:NMD3B_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NMD3B_HUMAN
PhylomeDB	O60391	http://phylomedb.org/?seqid=O60391
ProteinModelPortal	O60391	http://www.proteinmodelportal.org/query/uniprot/O60391
PubMed	11717388	http://www.ncbi.nlm.nih.gov/pubmed/11717388
PubMed	11735224	http://www.ncbi.nlm.nih.gov/pubmed/11735224
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	15722182	http://www.ncbi.nlm.nih.gov/pubmed/15722182
RefSeq	NP_619635	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_619635
SMART	SM00079	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00079
SMART	SM00918	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00918
STRING	9606.ENSP00000234389	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000234389&targetmode=cogs
SUPFAM	SSF53822	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822
UCSC	uc002lqo	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002lqo&org=rat
UniGene	Hs.660378	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.660378
UniProtKB	NMD3B_HUMAN	http://www.uniprot.org/uniprot/NMD3B_HUMAN
UniProtKB-AC	O60391	http://www.uniprot.org/uniprot/O60391
charge	swissprot:NMD3B_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NMD3B_HUMAN
eggNOG	ENOG410XNUR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNUR
eggNOG	KOG1053	http://eggnogapi.embl.de/nog_data/html/tree/KOG1053
epestfind	swissprot:NMD3B_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NMD3B_HUMAN
garnier	swissprot:NMD3B_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NMD3B_HUMAN
helixturnhelix	swissprot:NMD3B_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NMD3B_HUMAN
hmoment	swissprot:NMD3B_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NMD3B_HUMAN
iep	swissprot:NMD3B_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NMD3B_HUMAN
inforesidue	swissprot:NMD3B_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NMD3B_HUMAN
neXtProt	NX_O60391	http://www.nextprot.org/db/entry/NX_O60391
octanol	swissprot:NMD3B_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NMD3B_HUMAN
pepcoil	swissprot:NMD3B_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NMD3B_HUMAN
pepdigest	swissprot:NMD3B_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NMD3B_HUMAN
pepinfo	swissprot:NMD3B_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NMD3B_HUMAN
pepnet	swissprot:NMD3B_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NMD3B_HUMAN
pepstats	swissprot:NMD3B_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NMD3B_HUMAN
pepwheel	swissprot:NMD3B_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NMD3B_HUMAN
pepwindow	swissprot:NMD3B_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NMD3B_HUMAN
sigcleave	swissprot:NMD3B_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NMD3B_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	VPP3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=Q13488-1; Sequence=Displayed; Name=Short; IsoId=Q13488-2; Sequence=VSP_000345; Note=No experimental confirmation available.; 
# AltName	VPP3_HUMAN	Osteoclastic proton pump 116 kDa subunit
# AltName	VPP3_HUMAN	T-cell immune regulator 1
# AltName	VPP3_HUMAN	T-cell immune response cDNA7 protein
# AltName	VPP3_HUMAN	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3
# BioGrid	115597	20
# CCDS	CCDS53670	-. [Q13488-2]
# CCDS	CCDS8177	-. [Q13488-1]
# ChiTaRS	TCIRG1	human
# DISEASE	VPP3_HUMAN	Osteopetrosis, autosomal recessive 1 (OPTB1) [MIM 259700]  A rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. Osteopetrosis occurs in two forms  a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Recessive osteopetrosis commonly manifests in early infancy with macrocephaly, feeding difficulties, evolving blindness and deafness, bone marrow failure, severe anemia, and hepatosplenomegaly. Deafness and blindness are generally thought to represent effects of pressure on nerves. {ECO 0000269|PubMed 11532986, ECO 0000269|PubMed 12552563, ECO 0000269|PubMed 15300850}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000265686	ENSP00000265686; ENSG00000110719. [Q13488-1]
# Ensembl	ENST00000532635	ENSP00000434407; ENSG00000110719. [Q13488-2]
# ExpressionAtlas	Q13488	baseline and differential
# FUNCTION	VPP3_HUMAN	Part of the proton channel of V-ATPases (By similarity). Seems to be directly involved in T-cell activation. {ECO 0000250}. 
# GO_component	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
# GO_component	GO:0005739	mitochondrion; IEA:Ensembl.
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; TAS:ProtInc.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0010008	endosome membrane; TAS:Reactome.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016471	vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
# GO_component	GO:0030670	phagocytic vesicle membrane; TAS:Reactome.
# GO_function	GO:0005215	transporter activity; TAS:ProtInc.
# GO_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
# GO_function	GO:0051117	ATPase binding; IBA:GO_Central.
# GO_process	GO:0006968	cellular defense response; TAS:ProtInc.
# GO_process	GO:0007035	vacuolar acidification; IBA:GO_Central.
# GO_process	GO:0007039	protein catabolic process in the vacuole; ISS:ParkinsonsUK-UCL.
# GO_process	GO:0008284	positive regulation of cell proliferation; TAS:ProtInc.
# GO_process	GO:0008286	insulin receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0015986	ATP synthesis coupled proton transport; IBA:GO_Central.
# GO_process	GO:0015991	ATP hydrolysis coupled proton transport; IEA:InterPro.
# GO_process	GO:0015992	proton transport; TAS:ProtInc.
# GO_process	GO:0016236	macroautophagy; ISS:ParkinsonsUK-UCL.
# GO_process	GO:0033572	transferrin transport; TAS:Reactome.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
# GO_process	GO:0090383	phagosome acidification; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006914	autophagy
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009056	catabolic process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q13488	HS
# HGNC	HGNC:11647	TCIRG1
# IntAct	Q13488	6
# InterPro	IPR002490	V-ATPase_116kDa_su
# InterPro	IPR026028	V-type_ATPase_116kDa_su_euka
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Disease	H00436	[Skeletal dysplasia] Osteopetrosis, osteoclast poor
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04142	Lysosome
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04966	Collecting duct acid secretion
# KEGG_Pathway	ko05110	Vibrio cholerae infection
# KEGG_Pathway	ko05120	Epithelial cell signaling in Helicobacter pylori infection
# KEGG_Pathway	ko05152	Tuberculosis
# KEGG_Pathway	ko05323	Rheumatoid arthritis
# MIM	259700	phenotype
# MIM	604592	gene
# Organism	VPP3_HUMAN	Homo sapiens (Human)
# Orphanet	486	Autosomal dominant severe congenital neutropenia
# Orphanet	667	Autosomal recessive malignant osteopetrosis
# PANTHER	PTHR11629	PTHR11629
# PIRSF	PIRSF001293	ATP6V0A1
# Pfam	PF01496	V_ATPase_I
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-1222556	ROS, RNS production in response to bacteria
# Reactome	R-HSA-6798695	Neutrophil degranulation
# Reactome	R-HSA-77387	Insulin receptor recycling
# Reactome	R-HSA-917977	Transferrin endocytosis and recycling
# Reactome	R-HSA-983712	Ion channel transport
# RecName	VPP3_HUMAN	V-type proton ATPase 116 kDa subunit a isoform 3
# RefSeq	NP_006010	NM_006019.3. [Q13488-1]
# RefSeq	NP_006044	NM_006053.3. [Q13488-2]
# RefSeq	XP_005273766	XM_005273709.3. [Q13488-1]
# RefSeq	XP_011543028	XM_011544726.2. [Q13488-1]
# SIMILARITY	Belongs to the V-ATPase 116 kDa subunit family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	VPP3_HUMAN	Membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUBUNIT	VPP3_HUMAN	The V-ATPase is a heteromultimeric enzyme composed of at least thirteen different subunits. It has a membrane peripheral V1 sector for ATP hydrolysis and an integral V0 for proton translocation. The V1 sector comprises subunits A-H, whereas V0 includes subunits a, d, c, c', and c''. 
# TISSUE SPECIFICITY	VPP3_HUMAN	Isoform long is highly expressed in osteoclastomas. Isoform short is highly expressed in thymus. 
# UCSC	uc001one	human. [Q13488-1]
# WEB RESOURCE	VPP3_HUMAN	Name=TCIRG1base; Note=TCIRG1 mutation db; URL="http //structure.bmc.lu.se/idbase/TCIRG1base/";
# eggNOG	COG1269	LUCA
# eggNOG	KOG2189	Eukaryota
BLAST	swissprot:VPP3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VPP3_HUMAN
BioCyc	MetaCyc:ENSG00000110719-MONOMER	http://biocyc.org/getid?id=MetaCyc:ENSG00000110719-MONOMER
BioCyc	ZFISH:ENSG00000110719-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000110719-MONOMER
COG	COG1269	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1269
COXPRESdb	10312	http://coxpresdb.jp/data/gene/10312.shtml
CleanEx	HS_TCIRG1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TCIRG1
DOI	10.1002/humu.10165	http://dx.doi.org/10.1002/humu.10165
DOI	10.1002/humu.20076	http://dx.doi.org/10.1002/humu.20076
DOI	10.1006/bbrc.1996.0145	http://dx.doi.org/10.1006/bbrc.1996.0145
DOI	10.1006/geno.1999.5751	http://dx.doi.org/10.1006/geno.1999.5751
DOI	10.1093/hmg/10.17.1767	http://dx.doi.org/10.1093/hmg/10.17.1767
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF025374	http://www.ebi.ac.uk/ena/data/view/AF025374
EMBL	AF033033	http://www.ebi.ac.uk/ena/data/view/AF033033
EMBL	BC018133	http://www.ebi.ac.uk/ena/data/view/BC018133
EMBL	BC032465	http://www.ebi.ac.uk/ena/data/view/BC032465
EMBL	CH471076	http://www.ebi.ac.uk/ena/data/view/CH471076
EMBL	U45285	http://www.ebi.ac.uk/ena/data/view/U45285
Ensembl	ENST00000265686	http://www.ensembl.org/id/ENST00000265686
Ensembl	ENST00000532635	http://www.ensembl.org/id/ENST00000532635
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000220
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0010008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010008
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0016471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016471
GO_component	GO:0030670	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030670
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0046961	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046961
GO_function	GO:0051117	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051117
GO_process	GO:0006968	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006968
GO_process	GO:0007035	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007035
GO_process	GO:0007039	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007039
GO_process	GO:0008284	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008284
GO_process	GO:0008286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008286
GO_process	GO:0015986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015986
GO_process	GO:0015991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015991
GO_process	GO:0015992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992
GO_process	GO:0016236	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016236
GO_process	GO:0033572	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033572
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0070072	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070072
GO_process	GO:0090383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090383
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006914	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006914
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	TCIRG1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TCIRG1
GeneID	10312	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10312
GeneTree	ENSGT00390000004941	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000004941
HGNC	HGNC:11647	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11647
HOGENOM	HOG000037059	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000037059&db=HOGENOM6
HOVERGEN	HBG014606	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG014606&db=HOVERGEN
HPA	HPA038742	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA038742
InParanoid	Q13488	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q13488
IntAct	Q13488	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q13488*
InterPro	IPR002490	http://www.ebi.ac.uk/interpro/entry/IPR002490
InterPro	IPR026028	http://www.ebi.ac.uk/interpro/entry/IPR026028
Jabion	10312	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10312
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Disease	H00436	http://www.genome.jp/dbget-bin/www_bget?H00436
KEGG_Gene	hsa:10312	http://www.genome.jp/dbget-bin/www_bget?hsa:10312
KEGG_Orthology	KO:K02154	http://www.genome.jp/dbget-bin/www_bget?KO:K02154
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04142	http://www.genome.jp/kegg-bin/show_pathway?ko04142
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04966	http://www.genome.jp/kegg-bin/show_pathway?ko04966
KEGG_Pathway	ko05110	http://www.genome.jp/kegg-bin/show_pathway?ko05110
KEGG_Pathway	ko05120	http://www.genome.jp/kegg-bin/show_pathway?ko05120
KEGG_Pathway	ko05152	http://www.genome.jp/kegg-bin/show_pathway?ko05152
KEGG_Pathway	ko05323	http://www.genome.jp/kegg-bin/show_pathway?ko05323
MIM	259700	http://www.ncbi.nlm.nih.gov/omim/259700
MIM	604592	http://www.ncbi.nlm.nih.gov/omim/604592
OMA	MFLFSHS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MFLFSHS
Orphanet	486	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=486
Orphanet	667	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=667
OrthoDB	EOG091G031W	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G031W
PANTHER	PTHR11629	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11629
PSORT	swissprot:VPP3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VPP3_HUMAN
PSORT-B	swissprot:VPP3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VPP3_HUMAN
PSORT2	swissprot:VPP3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VPP3_HUMAN
Pfam	PF01496	http://pfam.xfam.org/family/PF01496
PharmGKB	PA36399	http://www.pharmgkb.org/do/serve?objId=PA36399&objCls=Gene
Phobius	swissprot:VPP3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VPP3_HUMAN
PhylomeDB	Q13488	http://phylomedb.org/?seqid=Q13488
ProteinModelPortal	Q13488	http://www.proteinmodelportal.org/query/uniprot/Q13488
PubMed	10329006	http://www.ncbi.nlm.nih.gov/pubmed/10329006
PubMed	11532986	http://www.ncbi.nlm.nih.gov/pubmed/11532986
PubMed	12552563	http://www.ncbi.nlm.nih.gov/pubmed/12552563
PubMed	15300850	http://www.ncbi.nlm.nih.gov/pubmed/15300850
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	8579597	http://www.ncbi.nlm.nih.gov/pubmed/8579597
Reactome	R-HSA-1222556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1222556
Reactome	R-HSA-6798695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6798695
Reactome	R-HSA-77387	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-77387
Reactome	R-HSA-917977	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917977
Reactome	R-HSA-983712	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983712
RefSeq	NP_006010	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006010
RefSeq	NP_006044	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006044
RefSeq	XP_005273766	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005273766
RefSeq	XP_011543028	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011543028
STRING	9606.ENSP00000265686	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000265686&targetmode=cogs
STRING	COG1269	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1269&targetmode=cogs
UCSC	uc001one	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001one&org=rat
UniGene	Hs.495985	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.495985
UniGene	Hs.716672	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.716672
UniProtKB	VPP3_HUMAN	http://www.uniprot.org/uniprot/VPP3_HUMAN
UniProtKB-AC	Q13488	http://www.uniprot.org/uniprot/Q13488
charge	swissprot:VPP3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VPP3_HUMAN
eggNOG	COG1269	http://eggnogapi.embl.de/nog_data/html/tree/COG1269
eggNOG	KOG2189	http://eggnogapi.embl.de/nog_data/html/tree/KOG2189
epestfind	swissprot:VPP3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VPP3_HUMAN
garnier	swissprot:VPP3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VPP3_HUMAN
helixturnhelix	swissprot:VPP3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VPP3_HUMAN
hmoment	swissprot:VPP3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VPP3_HUMAN
iep	swissprot:VPP3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VPP3_HUMAN
inforesidue	swissprot:VPP3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VPP3_HUMAN
neXtProt	NX_Q13488	http://www.nextprot.org/db/entry/NX_Q13488
octanol	swissprot:VPP3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VPP3_HUMAN
pepcoil	swissprot:VPP3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VPP3_HUMAN
pepdigest	swissprot:VPP3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VPP3_HUMAN
pepinfo	swissprot:VPP3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VPP3_HUMAN
pepnet	swissprot:VPP3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VPP3_HUMAN
pepstats	swissprot:VPP3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VPP3_HUMAN
pepwheel	swissprot:VPP3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VPP3_HUMAN
pepwindow	swissprot:VPP3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VPP3_HUMAN
sigcleave	swissprot:VPP3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VPP3_HUMAN
## Database	ID	URL or Descriptions
# AltName	XPO7_HUMAN	Ran-binding protein 16
# BioGrid	116678	88
# ChiTaRS	XPO7	human
# Ensembl	ENST00000252512	ENSP00000252512; ENSG00000130227
# ExpressionAtlas	Q9UIA9	baseline and differential
# FUNCTION	XPO7_HUMAN	Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO 0000269|PubMed 11024021, ECO 0000269|PubMed 15282546}. 
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005643	nuclear pore; IDA:UniProtKB.
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_function	GO:0005049	nuclear export signal receptor activity; IDA:UniProtKB.
# GO_function	GO:0008536	Ran GTPase binding; IBA:GO_Central.
# GO_process	GO:0006611	protein export from nucleus; IDA:UniProtKB.
# GO_process	GO:0051028	mRNA transport; IEA:UniProtKB-KW.
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# Genevisible	Q9UIA9	HS
# HGNC	HGNC:14108	XPO7
# INTERACTION	XPO7_HUMAN	P62826 RAN; NbExp=3; IntAct=EBI-286668, EBI-286642; O60763 USO1; NbExp=3; IntAct=EBI-286668, EBI-356164; 
# IntAct	Q9UIA9	11
# InterPro	IPR001494	Importin-beta_N
# InterPro	IPR016024	ARM-type_fold
# MIM	606140	gene
# Organism	XPO7_HUMAN	Homo sapiens (Human)
# PROSITE	PS50166	IMPORTIN_B_NT
# Pfam	PF03810	IBN_N
# Proteomes	UP000005640	Chromosome 8
# RecName	XPO7_HUMAN	Exportin-7
# RefSeq	NP_055839	NM_015024.4
# SEQUENCE CAUTION	Sequence=BAA34465.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the exportin family. {ECO	0000305}. 
# SIMILARITY	Contains 1 importin N-terminal domain. {ECO:0000255|PROSITE-ProRule	PRU00115}. 
# SMART	SM00913	IBN_N
# SUBCELLULAR LOCATION	XPO7_HUMAN	Cytoplasm. Nucleus {ECO 0000305}. Nucleus, nuclear pore complex {ECO 0000305}. Note=Shuttles between the nucleus and the cytoplasm. {ECO 0000305}. 
# SUBUNIT	XPO7_HUMAN	Binds to nucleoporins. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with ARHGAP1 and SFN. Interacts with Ran and cargo proteins in a GTP- dependent manner. {ECO 0000269|PubMed 11024021, ECO 0000269|PubMed 15282546}. 
# SUPFAM	SSF48371	SSF48371; 3
# TCDB	1.I.1.1	the nuclear pore complex (npc) family
# TISSUE SPECIFICITY	XPO7_HUMAN	Strong expression in testis, thyroid and bone marrow, low expression in lung, liver and small intestine, no expression in thymus, and remaining tissues studied have moderate expression. Expressed in red blood cells; overexpressed in red blood cells (cytoplasm) of patients with hereditary non- spherocytic hemolytic anemia of unknown etiology. {ECO 0000269|PubMed 11071879, ECO 0000269|PubMed 22509282}. 
# UCSC	uc003xaa	human
# eggNOG	ENOG410XRPR	LUCA
# eggNOG	KOG1410	Eukaryota
BLAST	swissprot:XPO7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:XPO7_HUMAN
BioCyc	ZFISH:ENSG00000130227-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000130227-MONOMER
COXPRESdb	23039	http://coxpresdb.jp/data/gene/23039.shtml
CleanEx	HS_XPO7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_XPO7
DOI	10.1006/bbrc.2000.3788	http://dx.doi.org/10.1006/bbrc.2000.3788
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/sj.emboj.7600338	http://dx.doi.org/10.1038/sj.emboj.7600338
DOI	10.1074/jbc.M006242200	http://dx.doi.org/10.1074/jbc.M006242200
DOI	10.1093/dnares/5.5.277	http://dx.doi.org/10.1093/dnares/5.5.277
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1371/journal.pone.0034237	http://dx.doi.org/10.1371/journal.pone.0034237
EMBL	AB018288	http://www.ebi.ac.uk/ena/data/view/AB018288
EMBL	AF064729	http://www.ebi.ac.uk/ena/data/view/AF064729
EMBL	BC014219	http://www.ebi.ac.uk/ena/data/view/BC014219
EMBL	BC030785	http://www.ebi.ac.uk/ena/data/view/BC030785
Ensembl	ENST00000252512	http://www.ensembl.org/id/ENST00000252512
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005643	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005643
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_function	GO:0005049	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005049
GO_function	GO:0008536	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008536
GO_process	GO:0006611	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006611
GO_process	GO:0051028	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051028
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
GeneCards	XPO7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=XPO7
GeneID	23039	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23039
GeneTree	ENSGT00730000110927	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00730000110927
HGNC	HGNC:14108	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14108
HOGENOM	HOG000018865	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000018865&db=HOGENOM6
HOVERGEN	HBG018869	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG018869&db=HOVERGEN
HPA	HPA043727	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA043727
HPA	HPA048153	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA048153
InParanoid	Q9UIA9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UIA9
IntAct	Q9UIA9	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9UIA9*
InterPro	IPR001494	http://www.ebi.ac.uk/interpro/entry/IPR001494
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
Jabion	23039	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=23039
KEGG_Gene	hsa:23039	http://www.genome.jp/dbget-bin/www_bget?hsa:23039
MIM	606140	http://www.ncbi.nlm.nih.gov/omim/606140
MINT	MINT-1151570	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1151570
PROSITE	PS50166	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50166
PSORT	swissprot:XPO7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:XPO7_HUMAN
PSORT-B	swissprot:XPO7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:XPO7_HUMAN
PSORT2	swissprot:XPO7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:XPO7_HUMAN
Pfam	PF03810	http://pfam.xfam.org/family/PF03810
PharmGKB	PA34207	http://www.pharmgkb.org/do/serve?objId=PA34207&objCls=Gene
Phobius	swissprot:XPO7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:XPO7_HUMAN
PhylomeDB	Q9UIA9	http://phylomedb.org/?seqid=Q9UIA9
ProteinModelPortal	Q9UIA9	http://www.proteinmodelportal.org/query/uniprot/Q9UIA9
PubMed	11024021	http://www.ncbi.nlm.nih.gov/pubmed/11024021
PubMed	11071879	http://www.ncbi.nlm.nih.gov/pubmed/11071879
PubMed	15282546	http://www.ncbi.nlm.nih.gov/pubmed/15282546
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22509282	http://www.ncbi.nlm.nih.gov/pubmed/22509282
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	9872452	http://www.ncbi.nlm.nih.gov/pubmed/9872452
RefSeq	NP_055839	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055839
SMART	SM00913	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00913
STRING	9606.ENSP00000252512	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000252512&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
TCDB	1.I.1.1	http://www.tcdb.org/search/result.php?tc=1.I.1.1
UCSC	uc003xaa	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003xaa&org=rat
UniGene	Hs.172685	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.172685
UniProtKB	XPO7_HUMAN	http://www.uniprot.org/uniprot/XPO7_HUMAN
UniProtKB-AC	Q9UIA9	http://www.uniprot.org/uniprot/Q9UIA9
charge	swissprot:XPO7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:XPO7_HUMAN
eggNOG	ENOG410XRPR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRPR
eggNOG	KOG1410	http://eggnogapi.embl.de/nog_data/html/tree/KOG1410
epestfind	swissprot:XPO7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:XPO7_HUMAN
garnier	swissprot:XPO7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:XPO7_HUMAN
helixturnhelix	swissprot:XPO7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:XPO7_HUMAN
hmoment	swissprot:XPO7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:XPO7_HUMAN
iep	swissprot:XPO7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:XPO7_HUMAN
inforesidue	swissprot:XPO7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:XPO7_HUMAN
neXtProt	NX_Q9UIA9	http://www.nextprot.org/db/entry/NX_Q9UIA9
octanol	swissprot:XPO7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:XPO7_HUMAN
pepcoil	swissprot:XPO7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:XPO7_HUMAN
pepdigest	swissprot:XPO7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:XPO7_HUMAN
pepinfo	swissprot:XPO7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:XPO7_HUMAN
pepnet	swissprot:XPO7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:XPO7_HUMAN
pepstats	swissprot:XPO7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:XPO7_HUMAN
pepwheel	swissprot:XPO7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:XPO7_HUMAN
pepwindow	swissprot:XPO7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:XPO7_HUMAN
sigcleave	swissprot:XPO7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:XPO7_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=COX15.1; IsoId=Q7KZN9-1; Sequence=Displayed; Name=2; Synonyms=COX15.2; IsoId=Q7KZN9-2; Sequence=VSP_011281; Note=Ref.1 (AAD08646) sequence is in conflict in position: 374	F->L. {ECO:0000305}; 
# BioGrid	107747	13
# CCDS	CCDS7481	-. [Q7KZN9-2]
# CCDS	CCDS7482	-. [Q7KZN9-1]
# ChiTaRS	COX15	human
# DISEASE	COX15_HUMAN	Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 2 (CEMCOX2) [MIM 615119]  An infantile disorder, with a rapidly progressive fatal course, characterized by cytochrome c oxidase deficiency. Clinical features include microcephaly, encephalopathy, hypertrophic cardiomyopathy, persistent lactic acidosis, respiratory distress, hypotonia and seizures. Postmortem cardiac muscle studies show marked complex IV deficiency. Complex IV activity is only slightly decreased in the skeletal muscle. {ECO 0000269|PubMed 12474143, ECO 0000269|PubMed 21412973}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	COX15_HUMAN	Leigh syndrome (LS) [MIM 256000]  An early-onset progressive neurodegenerative disorder characterized by the presence of focal, bilateral lesions in one or more areas of the central nervous system including the brainstem, thalamus, basal ganglia, cerebellum and spinal cord. Clinical features depend on which areas of the central nervous system are involved and include subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, and dysphagia. {ECO 0000269|PubMed 15235026, ECO 0000269|PubMed 15863660}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000016171	ENSP00000016171; ENSG00000014919. [Q7KZN9-1]
# Ensembl	ENST00000370483	ENSP00000359514; ENSG00000014919. [Q7KZN9-2]
# FUNCTION	COX15_HUMAN	May be involved in the biosynthesis of heme A. {ECO 0000269|PubMed 12474143}. 
# GO_component	GO:0005739	mitochondrion; IDA:BHF-UCL.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0005746	mitochondrial respiratory chain; TAS:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0070069	cytochrome complex; IDA:BHF-UCL.
# GO_function	GO:0004129	cytochrome-c oxidase activity; TAS:UniProtKB.
# GO_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors; TAS:Reactome.
# GO_function	GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor; IBA:GO_Central.
# GO_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen; IC:HGNC.
# GO_process	GO:0006783	heme biosynthetic process; TAS:Reactome.
# GO_process	GO:0006784	heme a biosynthetic process; IGI:HGNC.
# GO_process	GO:0007585	respiratory gaseous exchange; TAS:UniProtKB.
# GO_process	GO:0008535	respiratory chain complex IV assembly; IMP:HGNC.
# GO_process	GO:0045333	cellular respiration; IC:HGNC.
# GO_process	GO:0055114	oxidation-reduction process; TAS:UniProtKB.
# GO_process	GO:1902600	hydrogen ion transmembrane transport; IMP:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0051186	cofactor metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q7KZN9	HS
# HAMAP	MF_01665	HemeA_synth_type2
# HGNC	HGNC:2263	COX15
# IntAct	Q7KZN9	12
# InterPro	IPR003780	COX15/CtaA_fam
# InterPro	IPR009003	Peptidase_S1_PA
# InterPro	IPR023754	HemeA_Synthase_type2
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Disease	H01200	[Inherited metabolic disease] Fatal infantile cardioencephalomyopathy
# KEGG_Disease	H01354	[Inherited metabolic disease; Neurodegenerative disease; Mitochondrial disease] X-linked Leigh syndrome
# KEGG_Disease	H01368:[Inherited metabolic disease; Mitochondrial disease] Leber Hereditary Optic Neuropathy (LHON) [DS	H00068]
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko00860	Porphyrin and chlorophyll metabolism
# KEGG_Pathway	ko02020	Two-component system
# MIM	256000	phenotype
# MIM	603646	gene
# MIM	615119	phenotype
# Organism	COX15_HUMAN	Homo sapiens (Human)
# Orphanet	1561	Fatal infantile cytochrome C oxidase deficiency
# Orphanet	70474	Leigh syndrome with cardiomyopathy
# PATHWAY	Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O	 step 1/1. 
# Pfam	PF02628	COX15-CtaA
# Proteomes	UP000005640	Chromosome 10
# Reactome	R-HSA-189451	Heme biosynthesis
# RecName	COX15_HUMAN	Cytochrome c oxidase assembly protein COX15 homolog
# RefSeq	NP_001307903	NM_001320974.1
# RefSeq	NP_001307904	NM_001320975.1
# RefSeq	NP_001307905	NM_001320976.1
# RefSeq	NP_004367	NM_004376.6. [Q7KZN9-2]
# RefSeq	NP_510870	NM_078470.5. [Q7KZN9-1]
# SIMILARITY	Belongs to the COX15/CtaA family. {ECO	0000305}.
# SUBCELLULAR LOCATION	COX15_HUMAN	Mitochondrion membrane {ECO 0000269|PubMed 9878253}; Multi-pass membrane protein {ECO 0000269|PubMed 9878253}. 
# SUPFAM	SSF50494	SSF50494
# TISSUE SPECIFICITY	Predominantly found in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain. {ECO:0000269|PubMed	9878253}. 
# TopDownProteomics	Q7KZN9-1	-. [Q7KZN9-1]
# UCSC	uc001kqb	human. [Q7KZN9-1]
# UniPathway	UPA00269	UER00713
# eggNOG	COG1612	LUCA
# eggNOG	KOG2725	Eukaryota
BLAST	swissprot:COX15_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:COX15_HUMAN
COG	COG1612	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1612
COXPRESdb	1355	http://coxpresdb.jp/data/gene/1355.shtml
CleanEx	HS_COX15	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_COX15
DOI	10.1002/ajmg.a.33881	http://dx.doi.org/10.1002/ajmg.a.33881
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/geno.1998.5580	http://dx.doi.org/10.1006/geno.1998.5580
DOI	10.1038/nature02462	http://dx.doi.org/10.1038/nature02462
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1086/345489	http://dx.doi.org/10.1086/345489
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1136/jmg.2003.017426	http://dx.doi.org/10.1136/jmg.2003.017426
DOI	10.1136/jmg.2004.029926	http://dx.doi.org/10.1136/jmg.2004.029926
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF026850	http://www.ebi.ac.uk/ena/data/view/AF026850
EMBL	AF044323	http://www.ebi.ac.uk/ena/data/view/AF044323
EMBL	AK291654	http://www.ebi.ac.uk/ena/data/view/AK291654
EMBL	AL133353	http://www.ebi.ac.uk/ena/data/view/AL133353
EMBL	AL133353	http://www.ebi.ac.uk/ena/data/view/AL133353
EMBL	BC002382	http://www.ebi.ac.uk/ena/data/view/BC002382
EMBL	BC013403	http://www.ebi.ac.uk/ena/data/view/BC013403
EMBL	BC078161	http://www.ebi.ac.uk/ena/data/view/BC078161
EMBL	BT007129	http://www.ebi.ac.uk/ena/data/view/BT007129
EMBL	BX537557	http://www.ebi.ac.uk/ena/data/view/BX537557
EMBL	CH471066	http://www.ebi.ac.uk/ena/data/view/CH471066
Ensembl	ENST00000016171	http://www.ensembl.org/id/ENST00000016171
Ensembl	ENST00000370483	http://www.ensembl.org/id/ENST00000370483
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005746	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005746
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0070069	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070069
GO_function	GO:0004129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004129
GO_function	GO:0016627	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016627
GO_function	GO:0016653	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016653
GO_process	GO:0006123	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006123
GO_process	GO:0006783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006783
GO_process	GO:0006784	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006784
GO_process	GO:0007585	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007585
GO_process	GO:0008535	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008535
GO_process	GO:0045333	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045333
GO_process	GO:0055114	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114
GO_process	GO:1902600	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902600
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0051186	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	COX15	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=COX15
GeneID	1355	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1355
GeneTree	ENSGT00390000002223	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002223
HAMAP	MF_01665	http://hamap.expasy.org/unirule/MF_01665
HGNC	HGNC:2263	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2263
HOVERGEN	HBG051086	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051086&db=HOVERGEN
HPA	HPA037727	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA037727
HPA	HPA037728	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA037728
HPA	HPA066096	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA066096
InParanoid	Q7KZN9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q7KZN9
IntAct	Q7KZN9	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q7KZN9*
InterPro	IPR003780	http://www.ebi.ac.uk/interpro/entry/IPR003780
InterPro	IPR009003	http://www.ebi.ac.uk/interpro/entry/IPR009003
InterPro	IPR023754	http://www.ebi.ac.uk/interpro/entry/IPR023754
Jabion	1355	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1355
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Disease	H01200	http://www.genome.jp/dbget-bin/www_bget?H01200
KEGG_Disease	H01354	http://www.genome.jp/dbget-bin/www_bget?H01354
KEGG_Disease	H01368	http://www.genome.jp/dbget-bin/www_bget?H01368
KEGG_Gene	hsa:1355	http://www.genome.jp/dbget-bin/www_bget?hsa:1355
KEGG_Orthology	KO:K02259	http://www.genome.jp/dbget-bin/www_bget?KO:K02259
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko00860	http://www.genome.jp/kegg-bin/show_pathway?ko00860
KEGG_Pathway	ko02020	http://www.genome.jp/kegg-bin/show_pathway?ko02020
KEGG_Reaction	rn:R07412	http://www.genome.jp/dbget-bin/www_bget?rn:R07412
MIM	256000	http://www.ncbi.nlm.nih.gov/omim/256000
MIM	603646	http://www.ncbi.nlm.nih.gov/omim/603646
MIM	615119	http://www.ncbi.nlm.nih.gov/omim/615119
OMA	TALIYIV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TALIYIV
Orphanet	1561	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1561
Orphanet	70474	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=70474
OrthoDB	EOG091G08NN	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08NN
PSORT	swissprot:COX15_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:COX15_HUMAN
PSORT-B	swissprot:COX15_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:COX15_HUMAN
PSORT2	swissprot:COX15_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:COX15_HUMAN
Pfam	PF02628	http://pfam.xfam.org/family/PF02628
PharmGKB	PA26779	http://www.pharmgkb.org/do/serve?objId=PA26779&objCls=Gene
Phobius	swissprot:COX15_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:COX15_HUMAN
PhylomeDB	Q7KZN9	http://phylomedb.org/?seqid=Q7KZN9
ProteinModelPortal	Q7KZN9	http://www.proteinmodelportal.org/query/uniprot/Q7KZN9
PubMed	12474143	http://www.ncbi.nlm.nih.gov/pubmed/12474143
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15164054	http://www.ncbi.nlm.nih.gov/pubmed/15164054
PubMed	15235026	http://www.ncbi.nlm.nih.gov/pubmed/15235026
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15863660	http://www.ncbi.nlm.nih.gov/pubmed/15863660
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21412973	http://www.ncbi.nlm.nih.gov/pubmed/21412973
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	9878253	http://www.ncbi.nlm.nih.gov/pubmed/9878253
Reactome	R-HSA-189451	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-189451
RefSeq	NP_001307903	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001307903
RefSeq	NP_001307904	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001307904
RefSeq	NP_001307905	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001307905
RefSeq	NP_004367	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004367
RefSeq	NP_510870	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_510870
STRING	9606.ENSP00000016171	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000016171&targetmode=cogs
STRING	COG1612	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1612&targetmode=cogs
SUPFAM	SSF50494	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50494
UCSC	uc001kqb	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001kqb&org=rat
UniGene	Hs.28326	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.28326
UniProtKB	COX15_HUMAN	http://www.uniprot.org/uniprot/COX15_HUMAN
UniProtKB-AC	Q7KZN9	http://www.uniprot.org/uniprot/Q7KZN9
charge	swissprot:COX15_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:COX15_HUMAN
eggNOG	COG1612	http://eggnogapi.embl.de/nog_data/html/tree/COG1612
eggNOG	KOG2725	http://eggnogapi.embl.de/nog_data/html/tree/KOG2725
epestfind	swissprot:COX15_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:COX15_HUMAN
garnier	swissprot:COX15_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:COX15_HUMAN
helixturnhelix	swissprot:COX15_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:COX15_HUMAN
hmoment	swissprot:COX15_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:COX15_HUMAN
iep	swissprot:COX15_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:COX15_HUMAN
inforesidue	swissprot:COX15_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:COX15_HUMAN
neXtProt	NX_Q7KZN9	http://www.nextprot.org/db/entry/NX_Q7KZN9
octanol	swissprot:COX15_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:COX15_HUMAN
pepcoil	swissprot:COX15_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:COX15_HUMAN
pepdigest	swissprot:COX15_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:COX15_HUMAN
pepinfo	swissprot:COX15_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:COX15_HUMAN
pepnet	swissprot:COX15_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:COX15_HUMAN
pepstats	swissprot:COX15_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:COX15_HUMAN
pepwheel	swissprot:COX15_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:COX15_HUMAN
pepwindow	swissprot:COX15_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:COX15_HUMAN
sigcleave	swissprot:COX15_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:COX15_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S4A11_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8NBS3-1; Sequence=Displayed; Name=2; IsoId=Q8NBS3-2; Sequence=VSP_035891; Note=No experimental confirmation available.; Name=3; IsoId=Q8NBS3-3; Sequence=VSP_044846; Note=No experimental confirmation available.; Name=4; IsoId=Q8NBS3-4; Sequence=VSP_054049; 
# AltName	S4A11_HUMAN	Bicarbonate transporter-related protein 1
# AltName	S4A11_HUMAN	Sodium borate cotransporter 1
# AltName	S4A11_HUMAN	Solute carrier family 4 member 11
# CCDS	CCDS13052	-. [Q8NBS3-1]
# CCDS	CCDS54445	-. [Q8NBS3-4]
# CCDS	CCDS54446	-. [Q8NBS3-3]
# DISEASE	S4A11_HUMAN	Corneal dystrophy and perceptive deafness (CDPD) [MIM 217400]  An ocular disease characterized by the association of corneal clouding with progressive perceptive hearing loss. {ECO 0000269|PubMed 17220209}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	S4A11_HUMAN	Corneal dystrophy, Fuchs endothelial, 4 (FECD4) [MIM 613268]  A corneal disease caused by loss of endothelium of the central cornea. It is characterized by focal wart-like guttata that arise from Descemet membrane and develop in the central cornea, epithelial blisters, reduced vision and pain. Descemet membrane is thickened by abnormal collagenous deposition. {ECO 0000269|PubMed 18024964, ECO 0000269|PubMed 20848555, ECO 0000269|PubMed 25007886}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	S4A11_HUMAN	Corneal endothelial dystrophy (CHED) [MIM 217700]  A congenital corneal dystrophy characterized by thickening and opacification of the cornea, altered morphology of the endothelium, and secretion of an abnormal collagenous layer at the Descemet membrane. {ECO 0000269|PubMed 16767101, ECO 0000269|PubMed 16825429, ECO 0000269|PubMed 17220209, ECO 0000269|PubMed 17397048, ECO 0000269|PubMed 17679935, ECO 0000269|PubMed 18474783, ECO 0000269|PubMed 19369245, ECO 0000269|PubMed 20108384, ECO 0000269|PubMed 21203343, ECO 0000269|PubMed 26286922}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000380056	ENSP00000369396; ENSG00000088836. [Q8NBS3-1]
# Ensembl	ENST00000380059	ENSP00000369399; ENSG00000088836. [Q8NBS3-4]
# Ensembl	ENST00000539553	ENSP00000441370; ENSG00000088836. [Q8NBS3-3]
# ExpressionAtlas	Q8NBS3	baseline and differential
# FUNCTION	S4A11_HUMAN	Transporter which plays an important role in sodium- mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration (By similarity). Involved in borate homeostasis. In the absence of borate, it functions as a Na(+) and OH(-)(H(+)) channel. In the presence of borate functions as an electrogenic Na(+) coupled borate cotransporter. {ECO 0000250|UniProtKB A2AJN7, ECO 0000269|PubMed 15525507, ECO 0000269|PubMed 25007886}. 
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016323	basolateral plasma membrane; TAS:HGNC.
# GO_function	GO:0005272	sodium channel activity; IDA:HGNC.
# GO_function	GO:0005452	inorganic anion exchanger activity; IEA:InterPro.
# GO_function	GO:0015106	bicarbonate transmembrane transporter activity; IDA:HGNC.
# GO_function	GO:0015252	hydrogen ion channel activity; IDA:HGNC.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_function	GO:0046715	borate transmembrane transporter activity; IDA:HGNC.
# GO_function	GO:0046983	protein dimerization activity; IDA:UniProtKB.
# GO_function	S4A11_HUMAN	GO 0015301 anion anion antiporter activity; IEA UniProtKB-KW.
# GO_process	GO:0006814	sodium ion transport; IDA:HGNC.
# GO_process	GO:0015701	bicarbonate transport; IDA:HGNC.
# GO_process	GO:0015992	proton transport; IDA:HGNC.
# GO_process	GO:0030003	cellular cation homeostasis; IDA:HGNC.
# GO_process	GO:0042044	fluid transport; ISS:UniProtKB.
# GO_process	GO:0046713	borate transport; IDA:HGNC.
# GO_process	GO:0051453	regulation of intracellular pH; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0042592	homeostatic process
# Gene3D	3.40.930.10	-; 1.
# Genevisible	Q8NBS3	HS
# HGNC	HGNC:16438	SLC4A11
# InterPro	IPR002178	PTS_EIIA_type-2_dom
# InterPro	IPR003020	HCO3_transpt_euk
# InterPro	IPR011531	HCO3_transpt_C
# InterPro	IPR016152	PTrfase/Anion_transptr
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H00960	[Eye disease] Fuchs endothelial corneal dystrophy
# KEGG_Disease	H00963	[Eye disease] Harboyan syndrome
# MIM	217400	phenotype
# MIM	217700	phenotype
# MIM	610206	gene
# MIM	613268	phenotype
# Organism	S4A11_HUMAN	Homo sapiens (Human)
# Orphanet	1490	Corneal dystrophy - perceptive deafness
# Orphanet	293603	Congenital hereditary endothelial dystrophy type II
# Orphanet	98974	Fuchs endothelial corneal dystrophy
# PANTHER	PTHR11453	PTHR11453
# PRINTS	PR01231	HCO3TRNSPORT
# PTM	S4A11_HUMAN	Glycosylated. {ECO 0000269|PubMed 18024964}. 
# Pfam	PF00955	HCO3_cotransp
# Proteomes	UP000005640	Chromosome 20
# RecName	S4A11_HUMAN	Sodium bicarbonate transporter-like protein 11
# RefSeq	NP_001167560	NM_001174089.1. [Q8NBS3-3]
# RefSeq	NP_001167561	NM_001174090.1. [Q8NBS3-4]
# RefSeq	NP_114423	NM_032034.3. [Q8NBS3-1]
# SEQUENCE CAUTION	Sequence=BAC11536.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAB90170.4; Type=Erroneous gene model prediction; Evidence={ECO	0000305}; Sequence=CAD55942.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
# SIMILARITY	Belongs to the anion exchanger (TC 2.A.31) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S4A11_HUMAN	Cell membrane {ECO 0000269|PubMed 18024964, ECO 0000269|PubMed 25007886}. Membrane {ECO 0000269|PubMed 18024964}; Multi-pass membrane protein {ECO 0000269|PubMed 18024964}. 
# SUBUNIT	S4A11_HUMAN	Homodimer. 
# SUPFAM	SSF55804	SSF55804
# TCDB	2.A.31.4	the anion exchanger (ae) family
# TISSUE SPECIFICITY	S4A11_HUMAN	Widely expressed. Highly expressed in kidney, testis, salivary gland, thyroid, trachea and corneal endothelium. Not detected in retina and lymphocytes. {ECO 0000269|PubMed 11302728, ECO 0000269|PubMed 16767101}. 
# UCSC	uc002wig	human. [Q8NBS3-1]
# eggNOG	ENOG410XPHD	LUCA
# eggNOG	KOG1172	Eukaryota
BLAST	swissprot:S4A11_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S4A11_HUMAN
COXPRESdb	83959	http://coxpresdb.jp/data/gene/83959.shtml
CleanEx	HS_SLC4A11	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC4A11
DOI	10.1001/archopht.126.5.700	http://dx.doi.org/10.1001/archopht.126.5.700
DOI	10.1002/humu.21356	http://dx.doi.org/10.1002/humu.21356
DOI	10.1002/humu.21655	http://dx.doi.org/10.1002/humu.21655
DOI	10.1002/humu.9487	http://dx.doi.org/10.1002/humu.9487
DOI	10.1006/bbrc.2001.4692	http://dx.doi.org/10.1006/bbrc.2001.4692
DOI	10.1016/j.molcel.2004.09.030	http://dx.doi.org/10.1016/j.molcel.2004.09.030
DOI	10.1038/414865a	http://dx.doi.org/10.1038/414865a
DOI	10.1038/jhg.2014.55	http://dx.doi.org/10.1038/jhg.2014.55
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/ng1824	http://dx.doi.org/10.1038/ng1824
DOI	10.1074/jbc.M109.094680	http://dx.doi.org/10.1074/jbc.M109.094680
DOI	10.1093/hmg/ddm337	http://dx.doi.org/10.1093/hmg/ddm337
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/cxo.12276	http://dx.doi.org/10.1111/cxo.12276
DOI	10.1136/jmg.2006.044644	http://dx.doi.org/10.1136/jmg.2006.044644
DOI	10.1136/jmg.2006.046904	http://dx.doi.org/10.1136/jmg.2006.046904
DOI	10.1167/iovs.08-3006	http://dx.doi.org/10.1167/iovs.08-3006
EMBL	AF336127	http://www.ebi.ac.uk/ena/data/view/AF336127
EMBL	AK075303	http://www.ebi.ac.uk/ena/data/view/AK075303
EMBL	AK296508	http://www.ebi.ac.uk/ena/data/view/AK296508
EMBL	AK296760	http://www.ebi.ac.uk/ena/data/view/AK296760
EMBL	AL109976	http://www.ebi.ac.uk/ena/data/view/AL109976
EMBL	AL109976	http://www.ebi.ac.uk/ena/data/view/AL109976
EMBL	AL109976	http://www.ebi.ac.uk/ena/data/view/AL109976
EMBL	BC110540	http://www.ebi.ac.uk/ena/data/view/BC110540
EMBL	BC110541	http://www.ebi.ac.uk/ena/data/view/BC110541
EMBL	CH471133	http://www.ebi.ac.uk/ena/data/view/CH471133
Ensembl	ENST00000380056	http://www.ensembl.org/id/ENST00000380056
Ensembl	ENST00000380059	http://www.ensembl.org/id/ENST00000380059
Ensembl	ENST00000539553	http://www.ensembl.org/id/ENST00000539553
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_function	GO:0005272	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005272
GO_function	GO:0005452	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005452
GO_function	GO:0015106	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015106
GO_function	GO:0015252	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015252
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_function	GO:0015301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015301
GO_function	GO:0046715	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046715
GO_function	GO:0046983	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046983
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0015701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015701
GO_process	GO:0015992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992
GO_process	GO:0030003	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030003
GO_process	GO:0042044	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042044
GO_process	GO:0046713	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046713
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
Gene3D	3.40.930.10	http://www.cathdb.info/version/latest/superfamily/3.40.930.10
GeneCards	SLC4A11	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC4A11
GeneID	83959	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83959
GeneTree	ENSGT00760000119021	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119021
HGNC	HGNC:16438	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16438
HOGENOM	HOG000016966	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000016966&db=HOGENOM6
HOVERGEN	HBG079162	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG079162&db=HOVERGEN
HPA	HPA018120	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA018120
HPA	HPA058377	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA058377
InParanoid	Q8NBS3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8NBS3
InterPro	IPR002178	http://www.ebi.ac.uk/interpro/entry/IPR002178
InterPro	IPR003020	http://www.ebi.ac.uk/interpro/entry/IPR003020
InterPro	IPR011531	http://www.ebi.ac.uk/interpro/entry/IPR011531
InterPro	IPR016152	http://www.ebi.ac.uk/interpro/entry/IPR016152
Jabion	83959	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=83959
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00960	http://www.genome.jp/dbget-bin/www_bget?H00960
KEGG_Disease	H00963	http://www.genome.jp/dbget-bin/www_bget?H00963
KEGG_Gene	hsa:83959	http://www.genome.jp/dbget-bin/www_bget?hsa:83959
KEGG_Orthology	KO:K13862	http://www.genome.jp/dbget-bin/www_bget?KO:K13862
MIM	217400	http://www.ncbi.nlm.nih.gov/omim/217400
MIM	217700	http://www.ncbi.nlm.nih.gov/omim/217700
MIM	610206	http://www.ncbi.nlm.nih.gov/omim/610206
MIM	613268	http://www.ncbi.nlm.nih.gov/omim/613268
OMA	NSFYAWT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NSFYAWT
Orphanet	1490	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1490
Orphanet	293603	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=293603
Orphanet	98974	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98974
OrthoDB	EOG091G01E4	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01E4
PANTHER	PTHR11453	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11453
PRINTS	PR01231	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01231
PSORT	swissprot:S4A11_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S4A11_HUMAN
PSORT-B	swissprot:S4A11_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S4A11_HUMAN
PSORT2	swissprot:S4A11_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S4A11_HUMAN
Pfam	PF00955	http://pfam.xfam.org/family/PF00955
PharmGKB	PA38139	http://www.pharmgkb.org/do/serve?objId=PA38139&objCls=Gene
Phobius	swissprot:S4A11_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S4A11_HUMAN
PhylomeDB	Q8NBS3	http://phylomedb.org/?seqid=Q8NBS3
ProteinModelPortal	Q8NBS3	http://www.proteinmodelportal.org/query/uniprot/Q8NBS3
PubMed	11302728	http://www.ncbi.nlm.nih.gov/pubmed/11302728
PubMed	11780052	http://www.ncbi.nlm.nih.gov/pubmed/11780052
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15525507	http://www.ncbi.nlm.nih.gov/pubmed/15525507
PubMed	16767101	http://www.ncbi.nlm.nih.gov/pubmed/16767101
PubMed	16825429	http://www.ncbi.nlm.nih.gov/pubmed/16825429
PubMed	17220209	http://www.ncbi.nlm.nih.gov/pubmed/17220209
PubMed	17397048	http://www.ncbi.nlm.nih.gov/pubmed/17397048
PubMed	17679935	http://www.ncbi.nlm.nih.gov/pubmed/17679935
PubMed	18024964	http://www.ncbi.nlm.nih.gov/pubmed/18024964
PubMed	18474783	http://www.ncbi.nlm.nih.gov/pubmed/18474783
PubMed	19369245	http://www.ncbi.nlm.nih.gov/pubmed/19369245
PubMed	20108384	http://www.ncbi.nlm.nih.gov/pubmed/20108384
PubMed	20185830	http://www.ncbi.nlm.nih.gov/pubmed/20185830
PubMed	20848555	http://www.ncbi.nlm.nih.gov/pubmed/20848555
PubMed	21203343	http://www.ncbi.nlm.nih.gov/pubmed/21203343
PubMed	22072594	http://www.ncbi.nlm.nih.gov/pubmed/22072594
PubMed	25007886	http://www.ncbi.nlm.nih.gov/pubmed/25007886
PubMed	26286922	http://www.ncbi.nlm.nih.gov/pubmed/26286922
RefSeq	NP_001167560	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001167560
RefSeq	NP_001167561	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001167561
RefSeq	NP_114423	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_114423
STRING	9606.ENSP00000369399	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000369399&targetmode=cogs
SUPFAM	SSF55804	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55804
TCDB	2.A.31.4	http://www.tcdb.org/search/result.php?tc=2.A.31.4
UCSC	uc002wig	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002wig&org=rat
UniGene	Hs.105607	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.105607
UniProtKB	S4A11_HUMAN	http://www.uniprot.org/uniprot/S4A11_HUMAN
UniProtKB-AC	Q8NBS3	http://www.uniprot.org/uniprot/Q8NBS3
charge	swissprot:S4A11_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S4A11_HUMAN
eggNOG	ENOG410XPHD	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPHD
eggNOG	KOG1172	http://eggnogapi.embl.de/nog_data/html/tree/KOG1172
epestfind	swissprot:S4A11_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S4A11_HUMAN
garnier	swissprot:S4A11_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S4A11_HUMAN
helixturnhelix	swissprot:S4A11_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S4A11_HUMAN
hmoment	swissprot:S4A11_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S4A11_HUMAN
iep	swissprot:S4A11_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S4A11_HUMAN
inforesidue	swissprot:S4A11_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S4A11_HUMAN
neXtProt	NX_Q8NBS3	http://www.nextprot.org/db/entry/NX_Q8NBS3
octanol	swissprot:S4A11_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S4A11_HUMAN
pepcoil	swissprot:S4A11_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S4A11_HUMAN
pepdigest	swissprot:S4A11_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S4A11_HUMAN
pepinfo	swissprot:S4A11_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S4A11_HUMAN
pepnet	swissprot:S4A11_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S4A11_HUMAN
pepstats	swissprot:S4A11_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S4A11_HUMAN
pepwheel	swissprot:S4A11_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S4A11_HUMAN
pepwindow	swissprot:S4A11_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S4A11_HUMAN
sigcleave	swissprot:S4A11_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S4A11_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CTL5_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=A; IsoId=Q8NCS7-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q8NCS7-2; Sequence=VSP_015433; Name=3; IsoId=Q8NCS7-3; Sequence=VSP_036153, VSP_015433; 
# AltName	CTL5_HUMAN	Solute carrier family 44 member 5
# BioGrid	128491	8
# CCDS	CCDS44164	-. [Q8NCS7-2]
# CCDS	CCDS667	-. [Q8NCS7-1]
# ChiTaRS	SLC44A5	human
# Ensembl	ENST00000370859	ENSP00000359896; ENSG00000137968. [Q8NCS7-2]
# ExpressionAtlas	Q8NCS7	baseline and differential
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015220	choline transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0006656	phosphatidylcholine biosynthetic process; TAS:Reactome.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q8NCS7	HS
# HGNC	HGNC:28524	SLC44A5
# InterPro	IPR007603	Choline_transptr-like
# KEGG_Brite	ko02001	Solute carrier family
# Organism	CTL5_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12385	PTHR12385; 2
# Pfam	PF04515	Choline_transpo
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-1483191	Synthesis of PC
# Reactome	R-HSA-425366	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
# RecName	CTL5_HUMAN	Choline transporter-like protein 5
# RefSeq	NP_001123530	NM_001130058.1. [Q8NCS7-2]
# RefSeq	NP_001307212	NM_001320283.1
# RefSeq	NP_001307214	NM_001320285.1. [Q8NCS7-3]
# RefSeq	NP_001307216	NM_001320287.1. [Q8NCS7-3]
# RefSeq	NP_689910	NM_152697.4
# SEQUENCE CAUTION	Sequence=BAC03655.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the CTL (choline transporter-like) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	CTL5_HUMAN	Membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# TCDB	2.A.92.1	the choline transporter-like (ctl) family
# UCSC	uc001dgt	human. [Q8NCS7-1]
# eggNOG	ENOG410XS0P	LUCA
# eggNOG	KOG1362	Eukaryota
BLAST	swissprot:CTL5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CTL5_HUMAN
BioCyc	ZFISH:ENSG00000137968-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000137968-MONOMER
COXPRESdb	204962	http://coxpresdb.jp/data/gene/204962.shtml
CleanEx	HS_SLC44A5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC44A5
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1471-4159.2004.02962.x	http://dx.doi.org/10.1111/j.1471-4159.2004.02962.x
EMBL	AC118550	http://www.ebi.ac.uk/ena/data/view/AC118550
EMBL	AK091400	http://www.ebi.ac.uk/ena/data/view/AK091400
EMBL	AK093170	http://www.ebi.ac.uk/ena/data/view/AK093170
EMBL	BC028743	http://www.ebi.ac.uk/ena/data/view/BC028743
EMBL	BC034580	http://www.ebi.ac.uk/ena/data/view/BC034580
EMBL	BC051740	http://www.ebi.ac.uk/ena/data/view/BC051740
Ensembl	ENST00000370859	http://www.ensembl.org/id/ENST00000370859
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015220
GO_process	GO:0006656	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006656
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC44A5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC44A5
GeneID	204962	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=204962
GeneTree	ENSGT00550000074521	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074521
HGNC	HGNC:28524	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:28524
HOGENOM	HOG000007110	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007110&db=HOGENOM6
HOVERGEN	HBG062155	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG062155&db=HOVERGEN
HPA	HPA047455	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA047455
HPA	HPA051011	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA051011
InParanoid	Q8NCS7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8NCS7
InterPro	IPR007603	http://www.ebi.ac.uk/interpro/entry/IPR007603
Jabion	204962	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=204962
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:204962	http://www.genome.jp/dbget-bin/www_bget?hsa:204962
KEGG_Orthology	KO:K15377	http://www.genome.jp/dbget-bin/www_bget?KO:K15377
PANTHER	PTHR12385	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12385
PSORT	swissprot:CTL5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CTL5_HUMAN
PSORT-B	swissprot:CTL5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CTL5_HUMAN
PSORT2	swissprot:CTL5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CTL5_HUMAN
Pfam	PF04515	http://pfam.xfam.org/family/PF04515
PharmGKB	PA142670901	http://www.pharmgkb.org/do/serve?objId=PA142670901&objCls=Gene
Phobius	swissprot:CTL5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CTL5_HUMAN
ProteinModelPortal	Q8NCS7	http://www.proteinmodelportal.org/query/uniprot/Q8NCS7
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15715662	http://www.ncbi.nlm.nih.gov/pubmed/15715662
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
Reactome	R-HSA-1483191	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1483191
Reactome	R-HSA-425366	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425366
RefSeq	NP_001123530	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001123530
RefSeq	NP_001307212	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001307212
RefSeq	NP_001307214	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001307214
RefSeq	NP_001307216	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001307216
RefSeq	NP_689910	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_689910
STRING	9606.ENSP00000359892	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000359892&targetmode=cogs
TCDB	2.A.92.1	http://www.tcdb.org/search/result.php?tc=2.A.92.1
UCSC	uc001dgt	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001dgt&org=rat
UniGene	Hs.654821	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.654821
UniGene	Hs.662961	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.662961
UniProtKB	CTL5_HUMAN	http://www.uniprot.org/uniprot/CTL5_HUMAN
UniProtKB-AC	Q8NCS7	http://www.uniprot.org/uniprot/Q8NCS7
charge	swissprot:CTL5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CTL5_HUMAN
eggNOG	ENOG410XS0P	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS0P
eggNOG	KOG1362	http://eggnogapi.embl.de/nog_data/html/tree/KOG1362
epestfind	swissprot:CTL5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CTL5_HUMAN
garnier	swissprot:CTL5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CTL5_HUMAN
helixturnhelix	swissprot:CTL5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CTL5_HUMAN
hmoment	swissprot:CTL5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CTL5_HUMAN
iep	swissprot:CTL5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CTL5_HUMAN
inforesidue	swissprot:CTL5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CTL5_HUMAN
neXtProt	NX_Q8NCS7	http://www.nextprot.org/db/entry/NX_Q8NCS7
octanol	swissprot:CTL5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CTL5_HUMAN
pepcoil	swissprot:CTL5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CTL5_HUMAN
pepdigest	swissprot:CTL5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CTL5_HUMAN
pepinfo	swissprot:CTL5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CTL5_HUMAN
pepnet	swissprot:CTL5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CTL5_HUMAN
pepstats	swissprot:CTL5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CTL5_HUMAN
pepwheel	swissprot:CTL5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CTL5_HUMAN
pepwindow	swissprot:CTL5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CTL5_HUMAN
sigcleave	swissprot:CTL5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CTL5_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S15A4_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N697-1; Sequence=Displayed; Name=2; IsoId=Q8N697-2; Sequence=VSP_034052; 
# AltName	S15A4_HUMAN	Peptide transporter 4
# AltName	S15A4_HUMAN	Peptide/histidine transporter 1
# BioGrid	125714	10
# CCDS	CCDS9264	-. [Q8N697-1]
# ChiTaRS	SLC15A4	human
# Ensembl	ENST00000266771	ENSP00000266771; ENSG00000139370. [Q8N697-1]
# ExpressionAtlas	Q8N697	baseline and differential
# FUNCTION	S15A4_HUMAN	Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides. {ECO 0000269|PubMed 16289537}. 
# GO_component	GO:0005765	lysosomal membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	S15A4_HUMAN	GO 0015333 peptide proton symporter activity; TAS Reactome.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006857	oligopeptide transport; IEA:InterPro.
# GO_process	GO:0015031	protein transport; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q8N697	HS
# HGNC	HGNC:23090	SLC15A4
# InterPro	IPR000109	POT_fam
# InterPro	IPR018456	PTR2_symporter_CS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02001	Solute carrier family
# MIM	615806	gene
# Organism	S15A4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11654	PTHR11654
# PROSITE	PS01023	PTR2_2
# Pfam	PF00854	PTR2
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-427975	Proton/oligopeptide cotransporters
# Reactome	R-HSA-6798695	Neutrophil degranulation
# RecName	S15A4_HUMAN	Solute carrier family 15 member 4
# RefSeq	NP_663623	NM_145648.3. [Q8N697-1]
# SEQUENCE CAUTION	Sequence=AAI46804.1; Type=Frameshift; Positions=342; Evidence={ECO:0000305}; Sequence=AAK95565.1; Type=Frameshift; Positions=572; Evidence={ECO	0000305}; Sequence=AAQ04807.1; Type=Frameshift; Positions=497; Evidence={ECO:0000305};
# SIMILARITY	Belongs to the PTR2/POT transporter (TC 2.A.17) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S15A4_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF103473	SSF103473; 3
# TCDB	2.A.17.3.11	the proton-dependent oligopeptide transporter (pot/ptr) family
# TISSUE SPECIFICITY	S15A4_HUMAN	Highly expressed in skeletal muscle. Moderately expressed in kidney, liver, and heart. Weakly expressed in colon and brain. Expressed in low levels throughout the gastrointestinal tract and in Caco-2 cells. Expressed in retinal fragment epithelium (RPE) and neural retina. Expressed in small intestine, stomach, duodenum, jejunum, ileum and colon. {ECO 0000269|PubMed 11741232, ECO 0000269|PubMed 11741260, ECO 0000269|PubMed 16289537}. 
# UCSC	uc001uhu	human. [Q8N697-1]
# eggNOG	COG3104	LUCA
# eggNOG	KOG1237	Eukaryota
BLAST	swissprot:S15A4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S15A4_HUMAN
COXPRESdb	121260	http://coxpresdb.jp/data/gene/121260.shtml
CleanEx	HS_SLC15A4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC15A4
DIP	DIP-60839N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-60839N
DOI	10.1016/j.ejps.2005.09.014	http://dx.doi.org/10.1016/j.ejps.2005.09.014
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0404089101	http://dx.doi.org/10.1073/pnas.0404089101
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1208/ps020216	http://dx.doi.org/10.1208/ps020216
DOI	10.1208/ps030109	http://dx.doi.org/10.1208/ps030109
EMBL	AF461893	http://www.ebi.ac.uk/ena/data/view/AF461893
EMBL	AK095717	http://www.ebi.ac.uk/ena/data/view/AK095717
EMBL	AY038999	http://www.ebi.ac.uk/ena/data/view/AY038999
EMBL	AY050629	http://www.ebi.ac.uk/ena/data/view/AY050629
EMBL	BC028394	http://www.ebi.ac.uk/ena/data/view/BC028394
EMBL	BC146803	http://www.ebi.ac.uk/ena/data/view/BC146803
EMBL	CH471054	http://www.ebi.ac.uk/ena/data/view/CH471054
Ensembl	ENST00000266771	http://www.ensembl.org/id/ENST00000266771
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015333	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015333
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006857
GO_process	GO:0015031	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC15A4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC15A4
GeneID	121260	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=121260
GeneTree	ENSGT00530000062961	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062961
HGNC	HGNC:23090	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:23090
HOGENOM	HOG000143436	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000143436&db=HOGENOM6
HOVERGEN	HBG108431	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108431&db=HOVERGEN
HPA	HPA016713	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA016713
InParanoid	Q8N697	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8N697
IntAct	Q8N697	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8N697*
InterPro	IPR000109	http://www.ebi.ac.uk/interpro/entry/IPR000109
InterPro	IPR018456	http://www.ebi.ac.uk/interpro/entry/IPR018456
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	121260	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=121260
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:121260	http://www.genome.jp/dbget-bin/www_bget?hsa:121260
KEGG_Orthology	KO:K14638	http://www.genome.jp/dbget-bin/www_bget?KO:K14638
MIM	615806	http://www.ncbi.nlm.nih.gov/omim/615806
OMA	MEGERAP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MEGERAP
OrthoDB	EOG091G0GF9	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0GF9
PANTHER	PTHR11654	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11654
PROSITE	PS01023	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01023
PSORT	swissprot:S15A4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S15A4_HUMAN
PSORT-B	swissprot:S15A4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S15A4_HUMAN
PSORT2	swissprot:S15A4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S15A4_HUMAN
Pfam	PF00854	http://pfam.xfam.org/family/PF00854
PharmGKB	PA134928948	http://www.pharmgkb.org/do/serve?objId=PA134928948&objCls=Gene
Phobius	swissprot:S15A4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S15A4_HUMAN
PhylomeDB	Q8N697	http://phylomedb.org/?seqid=Q8N697
ProteinModelPortal	Q8N697	http://www.proteinmodelportal.org/query/uniprot/Q8N697
PubMed	11741232	http://www.ncbi.nlm.nih.gov/pubmed/11741232
PubMed	11741260	http://www.ncbi.nlm.nih.gov/pubmed/11741260
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15498874	http://www.ncbi.nlm.nih.gov/pubmed/15498874
PubMed	16289537	http://www.ncbi.nlm.nih.gov/pubmed/16289537
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
Reactome	R-HSA-427975	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-427975
Reactome	R-HSA-6798695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6798695
RefSeq	NP_663623	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_663623
STRING	9606.ENSP00000266771	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000266771&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.17.3.11	http://www.tcdb.org/search/result.php?tc=2.A.17.3.11
UCSC	uc001uhu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001uhu&org=rat
UniGene	Hs.507260	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.507260
UniProtKB	S15A4_HUMAN	http://www.uniprot.org/uniprot/S15A4_HUMAN
UniProtKB-AC	Q8N697	http://www.uniprot.org/uniprot/Q8N697
charge	swissprot:S15A4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S15A4_HUMAN
eggNOG	COG3104	http://eggnogapi.embl.de/nog_data/html/tree/COG3104
eggNOG	KOG1237	http://eggnogapi.embl.de/nog_data/html/tree/KOG1237
epestfind	swissprot:S15A4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S15A4_HUMAN
garnier	swissprot:S15A4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S15A4_HUMAN
helixturnhelix	swissprot:S15A4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S15A4_HUMAN
hmoment	swissprot:S15A4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S15A4_HUMAN
iep	swissprot:S15A4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S15A4_HUMAN
inforesidue	swissprot:S15A4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S15A4_HUMAN
neXtProt	NX_Q8N697	http://www.nextprot.org/db/entry/NX_Q8N697
octanol	swissprot:S15A4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S15A4_HUMAN
pepcoil	swissprot:S15A4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S15A4_HUMAN
pepdigest	swissprot:S15A4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S15A4_HUMAN
pepinfo	swissprot:S15A4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S15A4_HUMAN
pepnet	swissprot:S15A4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S15A4_HUMAN
pepstats	swissprot:S15A4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S15A4_HUMAN
pepwheel	swissprot:S15A4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S15A4_HUMAN
pepwindow	swissprot:S15A4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S15A4_HUMAN
sigcleave	swissprot:S15A4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S15A4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	DIC_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UBX3-1; Sequence=Displayed; Name=2; IsoId=Q9UBX3-2; Sequence=VSP_003267; Note=No experimental confirmation available.; 
# AltName	DIC_HUMAN	Solute carrier family 25 member 10
# BioGrid	107850	50
# CCDS	CCDS11786	-. [Q9UBX3-1]
# CCDS	CCDS59301	-. [Q9UBX3-2]
# ChiTaRS	SLC25A10	human
# DrugBank	DB00139	Succinic acid
# Ensembl	ENST00000331531	ENSP00000328403; ENSG00000183048. [Q9UBX3-2]
# Ensembl	ENST00000350690	ENSP00000345580; ENSG00000183048. [Q9UBX3-1]
# ExpressionAtlas	Q9UBX3	baseline and differential
# FUNCTION	DIC_HUMAN	Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane. 
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005310	dicarboxylic acid transmembrane transporter activity; TAS:Reactome.
# GO_process	DIC_HUMAN	GO 0070221 sulfide oxidation, using sulfide quinone oxidoreductase; TAS Reactome.
# GO_process	GO:0006094	gluconeogenesis; TAS:Reactome.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006835	dicarboxylic acid transport; TAS:ProtInc.
# GO_process	GO:0006839	mitochondrial transport; IEA:InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0005975	carbohydrate metabolic process
# GOslim_process	GO:0006790	sulfur compound metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0044281	small molecule metabolic process
# Gene3D	1.50.40.10	-; 1.
# Genevisible	Q9UBX3	HS
# HGNC	HGNC:10980	SLC25A10
# INTERACTION	DIC_HUMAN	Q6A162 KRT40; NbExp=3; IntAct=EBI-750394, EBI-10171697; P60410 KRTAP10-8; NbExp=3; IntAct=EBI-750394, EBI-10171774; Q9BYR5 KRTAP4-2; NbExp=3; IntAct=EBI-750394, EBI-10172511; P26371 KRTAP5-9; NbExp=3; IntAct=EBI-750394, EBI-3958099; Q99750 MDFI; NbExp=7; IntAct=EBI-750394, EBI-724076; Q7Z3S9 NOTCH2NL; NbExp=3; IntAct=EBI-750394, EBI-945833; 
# IntAct	Q9UBX3	19
# InterPro	IPR002030	Mit_uncoupling
# InterPro	IPR018108	Mitochondrial_sb/sol_carrier
# InterPro	IPR023395	Mt_carrier_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04964	Proximal tubule bicarbonate reclamation
# MIM	606794	gene
# Organism	DIC_HUMAN	Homo sapiens (Human)
# PRINTS	PR00784	MTUNCOUPLING
# PROSITE	PS50920	SOLCAR; 3
# Pfam	PF00153	Mito_carr; 3
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-1614517	Sulfide oxidation to sulfate
# Reactome	R-HSA-428643	Organic anion transporters
# Reactome	R-HSA-70263	Gluconeogenesis
# RecName	DIC_HUMAN	Mitochondrial dicarboxylate carrier
# RefSeq	NP_001257817	NM_001270888.1. [Q9UBX3-2]
# RefSeq	NP_001257882	NM_001270953.1
# RefSeq	NP_036272	NM_012140.4. [Q9UBX3-1]
# SIMILARITY	Belongs to the mitochondrial carrier (TC 2.A.29) family. {ECO	0000305}. 
# SIMILARITY	Contains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule	PRU00282}.
# SUBCELLULAR LOCATION	DIC_HUMAN	Mitochondrion inner membrane; Multi-pass membrane protein. 
# SUPFAM	SSF103506	SSF103506
# TCDB	2.A.29.2	the mitochondrial carrier (mc) family
# TISSUE SPECIFICITY	Present in high amounts in liver and kidney, and at lower levels in all the other tissues analyzed. {ECO:0000269|PubMed	10585886}. 
# UCSC	uc002kbi	human. [Q9UBX3-1]
# eggNOG	ENOG410XQHU	LUCA
# eggNOG	KOG0759	Eukaryota
BLAST	swissprot:DIC_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:DIC_HUMAN
BioCyc	ZFISH:G66-31659-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31659-MONOMER
COXPRESdb	1468	http://coxpresdb.jp/data/gene/1468.shtml
CleanEx	HS_SLC25A10	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC25A10
DOI	10.1042/bj3440953	http://dx.doi.org/10.1042/bj3440953
DOI	10.1093/dnares/12.2.117	http://dx.doi.org/10.1093/dnares/12.2.117
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DrugBank	DB00139	http://www.drugbank.ca/drugs/DB00139
EMBL	AJ131612	http://www.ebi.ac.uk/ena/data/view/AJ131612
EMBL	AJ131613	http://www.ebi.ac.uk/ena/data/view/AJ131613
EMBL	AK075249	http://www.ebi.ac.uk/ena/data/view/AK075249
EMBL	BC007355	http://www.ebi.ac.uk/ena/data/view/BC007355
EMBL	BC015797	http://www.ebi.ac.uk/ena/data/view/BC015797
EMBL	CH471099	http://www.ebi.ac.uk/ena/data/view/CH471099
Ensembl	ENST00000331531	http://www.ensembl.org/id/ENST00000331531
Ensembl	ENST00000350690	http://www.ensembl.org/id/ENST00000350690
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005310	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005310
GO_process	GO:0006094	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006094
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006835	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006835
GO_process	GO:0006839	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006839
GO_process	GO:0070221	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070221
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GOslim_process	GO:0006790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
Gene3D	1.50.40.10	http://www.cathdb.info/version/latest/superfamily/1.50.40.10
GeneCards	SLC25A10	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC25A10
GeneID	1468	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1468
GeneTree	ENSGT00760000119170	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119170
HGNC	HGNC:10980	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10980
HOGENOM	HOG000165139	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000165139&db=HOGENOM6
HOVERGEN	HBG009528	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG009528&db=HOVERGEN
HPA	HPA023048	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA023048
InParanoid	Q9UBX3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UBX3
IntAct	Q9UBX3	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9UBX3*
InterPro	IPR002030	http://www.ebi.ac.uk/interpro/entry/IPR002030
InterPro	IPR018108	http://www.ebi.ac.uk/interpro/entry/IPR018108
InterPro	IPR023395	http://www.ebi.ac.uk/interpro/entry/IPR023395
Jabion	1468	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1468
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:1468	http://www.genome.jp/dbget-bin/www_bget?hsa:1468
KEGG_Orthology	KO:K13577	http://www.genome.jp/dbget-bin/www_bget?KO:K13577
KEGG_Pathway	ko04964	http://www.genome.jp/kegg-bin/show_pathway?ko04964
MIM	606794	http://www.ncbi.nlm.nih.gov/omim/606794
MINT	MINT-1477100	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1477100
OMA	MAVHVVK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MAVHVVK
PRINTS	PR00784	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00784
PROSITE	PS50920	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50920
PSORT	swissprot:DIC_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:DIC_HUMAN
PSORT-B	swissprot:DIC_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:DIC_HUMAN
PSORT2	swissprot:DIC_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:DIC_HUMAN
Pfam	PF00153	http://pfam.xfam.org/family/PF00153
PharmGKB	PA35856	http://www.pharmgkb.org/do/serve?objId=PA35856&objCls=Gene
Phobius	swissprot:DIC_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:DIC_HUMAN
PhylomeDB	Q9UBX3	http://phylomedb.org/?seqid=Q9UBX3
ProteinModelPortal	Q9UBX3	http://www.proteinmodelportal.org/query/uniprot/Q9UBX3
PubMed	10585886	http://www.ncbi.nlm.nih.gov/pubmed/10585886
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16303743	http://www.ncbi.nlm.nih.gov/pubmed/16303743
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
Reactome	R-HSA-1614517	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1614517
Reactome	R-HSA-428643	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428643
Reactome	R-HSA-70263	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-70263
RefSeq	NP_001257817	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001257817
RefSeq	NP_001257882	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001257882
RefSeq	NP_036272	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_036272
STRING	9606.ENSP00000345580	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000345580&targetmode=cogs
SUPFAM	SSF103506	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103506
TCDB	2.A.29.2	http://www.tcdb.org/search/result.php?tc=2.A.29.2
UCSC	uc002kbi	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002kbi&org=rat
UniGene	Hs.548187	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.548187
UniProtKB	DIC_HUMAN	http://www.uniprot.org/uniprot/DIC_HUMAN
UniProtKB-AC	Q9UBX3	http://www.uniprot.org/uniprot/Q9UBX3
charge	swissprot:DIC_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:DIC_HUMAN
eggNOG	ENOG410XQHU	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQHU
eggNOG	KOG0759	http://eggnogapi.embl.de/nog_data/html/tree/KOG0759
epestfind	swissprot:DIC_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:DIC_HUMAN
garnier	swissprot:DIC_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:DIC_HUMAN
helixturnhelix	swissprot:DIC_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:DIC_HUMAN
hmoment	swissprot:DIC_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:DIC_HUMAN
iep	swissprot:DIC_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:DIC_HUMAN
inforesidue	swissprot:DIC_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:DIC_HUMAN
neXtProt	NX_Q9UBX3	http://www.nextprot.org/db/entry/NX_Q9UBX3
octanol	swissprot:DIC_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:DIC_HUMAN
pepcoil	swissprot:DIC_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:DIC_HUMAN
pepdigest	swissprot:DIC_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:DIC_HUMAN
pepinfo	swissprot:DIC_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:DIC_HUMAN
pepnet	swissprot:DIC_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:DIC_HUMAN
pepstats	swissprot:DIC_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:DIC_HUMAN
pepwheel	swissprot:DIC_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:DIC_HUMAN
pepwindow	swissprot:DIC_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:DIC_HUMAN
sigcleave	swissprot:DIC_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:DIC_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GTR14_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=GLUT14-L; IsoId=Q8TDB8-1; Sequence=Displayed; Name=2; Synonyms=GLUT14-S; IsoId=Q8TDB8-2; Sequence=VSP_014450; Name=3; IsoId=Q8TDB8-3; Sequence=VSP_014449; Note=No experimental confirmation available.; Name=4; IsoId=Q8TDB8-4; Sequence=VSP_055253; Note=No experimental confirmation available.; Name=5; IsoId=Q8TDB8-5; Sequence=VSP_055254; Note=No experimental confirmation available.; 
# AltName	GTR14_HUMAN	Glucose transporter type 14
# BioGrid	126837	7
# CCDS	CCDS66300	-. [Q8TDB8-4]
# CCDS	CCDS66301	-. [Q8TDB8-2]
# CCDS	CCDS66302	-. [Q8TDB8-5]
# CCDS	CCDS8585	-. [Q8TDB8-1]
# CDD	cd06174	MFS
# Ensembl	ENST00000340749	ENSP00000340450; ENSG00000173262. [Q8TDB8-2]
# Ensembl	ENST00000396589	ENSP00000379834; ENSG00000173262. [Q8TDB8-1]
# Ensembl	ENST00000431042	ENSP00000407287; ENSG00000173262. [Q8TDB8-2]
# Ensembl	ENST00000535295	ENSP00000440492; ENSG00000173262. [Q8TDB8-4]
# Ensembl	ENST00000539924	ENSP00000445929; ENSG00000173262. [Q8TDB8-5]
# Ensembl	ENST00000542505	ENSP00000438484; ENSG00000173262. [Q8TDB8-3]
# Ensembl	ENST00000542546	ENSP00000443903; ENSG00000173262. [Q8TDB8-4]
# Ensembl	ENST00000543909	ENSP00000440480; ENSG00000173262. [Q8TDB8-1]
# Ensembl	ENST00000616981	ENSP00000482927; ENSG00000173262. [Q8TDB8-1]
# ExpressionAtlas	Q8TDB8	baseline and differential
# FUNCTION	GTR14_HUMAN	Facilitative glucose transporter (By similarity). May have a specific function related to spermatogenesis. {ECO 0000250}. 
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005355	glucose transmembrane transporter activity; IEA:InterPro.
# GO_process	GO:0007275	multicellular organism development; IEA:UniProtKB-KW.
# GO_process	GO:0007283	spermatogenesis; IEA:UniProtKB-KW.
# GO_process	GO:0030154	cell differentiation; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0048856	anatomical structure development
# Genevisible	Q8TDB8	HS
# HGNC	HGNC:18301	SLC2A14
# InterPro	IPR002945	Glc_transpt_3
# InterPro	IPR003663	Sugar/inositol_transpt
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR005829	Sugar_transporter_CS
# InterPro	IPR020846	MFS_dom
# MIM	611039	gene
# MISCELLANEOUS	GTR14_HUMAN	GLUT14 is a recent (less than 5 M year old) duplication of GLUT3. 
# Organism	GTR14_HUMAN	Homo sapiens (Human)
# PRINTS	PR00171	SUGRTRNSPORT
# PRINTS	PR01192	GLUCTRSPORT3
# PROSITE	PS00216	SUGAR_TRANSPORT_1
# PROSITE	PS00217	SUGAR_TRANSPORT_2
# PROSITE	PS50850	MFS
# Pfam	PF00083	Sugar_tr
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-428790	Facilitative Na+-independent glucose transporters
# Reactome	R-HSA-70153	Glucose transport
# RecName	GTR14_HUMAN	Solute carrier family 2, facilitated glucose transporter member 14
# RefSeq	NP_001273162	NM_001286233.1. [Q8TDB8-1]
# RefSeq	NP_001273163	NM_001286234.1. [Q8TDB8-2]
# RefSeq	NP_001273164	NM_001286235.1. [Q8TDB8-2]
# RefSeq	NP_001273165	NM_001286236.1. [Q8TDB8-4]
# RefSeq	NP_001273166	NM_001286237.1. [Q8TDB8-5]
# RefSeq	NP_703150	NM_153449.3. [Q8TDB8-1]
# RefSeq	XP_005253372	XM_005253315.3. [Q8TDB8-2]
# RefSeq	XP_005253374	XM_005253317.4. [Q8TDB8-2]
# RefSeq	XP_011518864	XM_011520562.1. [Q8TDB8-2]
# RefSeq	XP_011518865	XM_011520563.2. [Q8TDB8-2]
# RefSeq	XP_011518866	XM_011520564.2. [Q8TDB8-4]
# RefSeq	XP_011518867	XM_011520565.2. [Q8TDB8-4]
# RefSeq	XP_016874335	XM_017018846.1. [Q8TDB8-2]
# RefSeq	XP_016874336	XM_017018847.1. [Q8TDB8-2]
# SIMILARITY	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	GTR14_HUMAN	Membrane; Multi-pass membrane protein. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.1.1.90	the major facilitator superfamily (mfs)
# TIGRFAMs	TIGR00879	SP
# TISSUE SPECIFICITY	Expressed mainly in testis. {ECO:0000269|PubMed	12504846}. 
# UCSC	uc001qtk	human. [Q8TDB8-1]
# eggNOG	COG0477	LUCA
# eggNOG	KOG0569	Eukaryota
BLAST	swissprot:GTR14_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GTR14_HUMAN
BioCyc	ZFISH:ENSG00000173262-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000173262-MONOMER
COXPRESdb	144195	http://coxpresdb.jp/data/gene/144195.shtml
CleanEx	HS_SLC2A14	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC2A14
DOI	10.1006/geno.2002.7010	http://dx.doi.org/10.1006/geno.2002.7010
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AC006517	http://www.ebi.ac.uk/ena/data/view/AC006517
EMBL	AC007536	http://www.ebi.ac.uk/ena/data/view/AC007536
EMBL	AC124891	http://www.ebi.ac.uk/ena/data/view/AC124891
EMBL	AF481878	http://www.ebi.ac.uk/ena/data/view/AF481878
EMBL	AF481879	http://www.ebi.ac.uk/ena/data/view/AF481879
EMBL	AK122783	http://www.ebi.ac.uk/ena/data/view/AK122783
EMBL	AK126026	http://www.ebi.ac.uk/ena/data/view/AK126026
EMBL	AK302881	http://www.ebi.ac.uk/ena/data/view/AK302881
EMBL	AK316238	http://www.ebi.ac.uk/ena/data/view/AK316238
EMBL	AL110298	http://www.ebi.ac.uk/ena/data/view/AL110298
EMBL	AY357941	http://www.ebi.ac.uk/ena/data/view/AY357941
EMBL	BC060766	http://www.ebi.ac.uk/ena/data/view/BC060766
EMBL	CH471116	http://www.ebi.ac.uk/ena/data/view/CH471116
EMBL	CH471116	http://www.ebi.ac.uk/ena/data/view/CH471116
Ensembl	ENST00000340749	http://www.ensembl.org/id/ENST00000340749
Ensembl	ENST00000396589	http://www.ensembl.org/id/ENST00000396589
Ensembl	ENST00000431042	http://www.ensembl.org/id/ENST00000431042
Ensembl	ENST00000535295	http://www.ensembl.org/id/ENST00000535295
Ensembl	ENST00000539924	http://www.ensembl.org/id/ENST00000539924
Ensembl	ENST00000542505	http://www.ensembl.org/id/ENST00000542505
Ensembl	ENST00000542546	http://www.ensembl.org/id/ENST00000542546
Ensembl	ENST00000543909	http://www.ensembl.org/id/ENST00000543909
Ensembl	ENST00000616981	http://www.ensembl.org/id/ENST00000616981
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005355	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005355
GO_process	GO:0007275	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007275
GO_process	GO:0007283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007283
GO_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GeneCards	SLC2A14	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC2A14
GeneID	144195	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=144195
GeneTree	ENSGT00760000119022	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119022
HGNC	HGNC:18301	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18301
HOGENOM	HOG000202871	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202871&db=HOGENOM6
HOVERGEN	HBG014816	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG014816&db=HOVERGEN
HPA	HPA006539	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA006539
InParanoid	Q8TDB8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8TDB8
InterPro	IPR002945	http://www.ebi.ac.uk/interpro/entry/IPR002945
InterPro	IPR003663	http://www.ebi.ac.uk/interpro/entry/IPR003663
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR005829	http://www.ebi.ac.uk/interpro/entry/IPR005829
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	144195	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=144195
KEGG_Gene	hsa:144195	http://www.genome.jp/dbget-bin/www_bget?hsa:144195
MIM	611039	http://www.ncbi.nlm.nih.gov/omim/611039
OMA	MAICSII	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MAICSII
OrthoDB	EOG091G0A9K	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0A9K
PRINTS	PR00171	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00171
PRINTS	PR01192	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01192
PROSITE	PS00216	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00216
PROSITE	PS00217	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00217
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:GTR14_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GTR14_HUMAN
PSORT-B	swissprot:GTR14_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GTR14_HUMAN
PSORT2	swissprot:GTR14_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GTR14_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
PharmGKB	PA134885058	http://www.pharmgkb.org/do/serve?objId=PA134885058&objCls=Gene
Phobius	swissprot:GTR14_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GTR14_HUMAN
PhylomeDB	Q8TDB8	http://phylomedb.org/?seqid=Q8TDB8
ProteinModelPortal	Q8TDB8	http://www.proteinmodelportal.org/query/uniprot/Q8TDB8
PubMed	12504846	http://www.ncbi.nlm.nih.gov/pubmed/12504846
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
Reactome	R-HSA-428790	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428790
Reactome	R-HSA-70153	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-70153
RefSeq	NP_001273162	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273162
RefSeq	NP_001273163	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273163
RefSeq	NP_001273164	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273164
RefSeq	NP_001273165	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273165
RefSeq	NP_001273166	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273166
RefSeq	NP_703150	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_703150
RefSeq	XP_005253372	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005253372
RefSeq	XP_005253374	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005253374
RefSeq	XP_011518864	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011518864
RefSeq	XP_011518865	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011518865
RefSeq	XP_011518866	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011518866
RefSeq	XP_011518867	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011518867
RefSeq	XP_016874335	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016874335
RefSeq	XP_016874336	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016874336
SMR	Q8TDB8	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8TDB8
STRING	9606.ENSP00000379834	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000379834&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.1.90	http://www.tcdb.org/search/result.php?tc=2.A.1.1.90
TIGRFAMs	TIGR00879	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00879
UCSC	uc001qtk	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001qtk&org=rat
UniGene	Hs.655169	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.655169
UniGene	Hs.739527	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.739527
UniProtKB	GTR14_HUMAN	http://www.uniprot.org/uniprot/GTR14_HUMAN
UniProtKB-AC	Q8TDB8	http://www.uniprot.org/uniprot/Q8TDB8
charge	swissprot:GTR14_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GTR14_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG0569	http://eggnogapi.embl.de/nog_data/html/tree/KOG0569
epestfind	swissprot:GTR14_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GTR14_HUMAN
garnier	swissprot:GTR14_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GTR14_HUMAN
helixturnhelix	swissprot:GTR14_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GTR14_HUMAN
hmoment	swissprot:GTR14_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GTR14_HUMAN
iep	swissprot:GTR14_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GTR14_HUMAN
inforesidue	swissprot:GTR14_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GTR14_HUMAN
neXtProt	NX_Q8TDB8	http://www.nextprot.org/db/entry/NX_Q8TDB8
octanol	swissprot:GTR14_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GTR14_HUMAN
pepcoil	swissprot:GTR14_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GTR14_HUMAN
pepdigest	swissprot:GTR14_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GTR14_HUMAN
pepinfo	swissprot:GTR14_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GTR14_HUMAN
pepnet	swissprot:GTR14_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GTR14_HUMAN
pepstats	swissprot:GTR14_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GTR14_HUMAN
pepwheel	swissprot:GTR14_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GTR14_HUMAN
pepwindow	swissprot:GTR14_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GTR14_HUMAN
sigcleave	swissprot:GTR14_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GTR14_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ANO4_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q32M45-1; Sequence=Displayed; Name=2; IsoId=Q32M45-2; Sequence=VSP_025742; Name=3; IsoId=Q32M45-3; Sequence=VSP_025741, VSP_025743; Note=No experimental confirmation available.; 
# AltName	ANO4_HUMAN	Transmembrane protein 16D
# CCDS	CCDS31884	-. [Q32M45-2]
# CCDS	CCDS66445	-. [Q32M45-1]
# ChiTaRS	ANO4	human
# Ensembl	ENST00000392977	ENSP00000376703; ENSG00000151572. [Q32M45-1]
# Ensembl	ENST00000392979	ENSP00000376705; ENSG00000151572. [Q32M45-2]
# Ensembl	ENST00000550015	ENSP00000450192; ENSG00000151572. [Q32M45-3]
# Ensembl	ENST00000570509	ENSP00000471431; ENSG00000262139
# Ensembl	ENST00000573650	ENSP00000469449; ENSG00000262139
# Ensembl	ENST00000575847	ENSP00000470039; ENSG00000262139
# Ensembl	ENST00000594618	ENSP00000471210; ENSG00000262139
# ExpressionAtlas	Q32M45	baseline and differential
# FUNCTION	ANO4_HUMAN	Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity. {ECO 0000250|UniProtKB Q8C5H1}. 
# GO_component	GO:0005622	intracellular; ISS:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005229	intracellular calcium activated chloride channel activity; IDA:UniProtKB.
# GO_function	GO:0017128	phospholipid scramblase activity; IEA:Ensembl.
# GO_process	GO:0006821	chloride transport; IDA:UniProtKB.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0061589	calcium activated phosphatidylserine scrambling; IEA:Ensembl.
# GO_process	GO:0061590	calcium activated phosphatidylcholine scrambling; IEA:Ensembl.
# GO_process	GO:0061591	calcium activated galactosylceramide scrambling; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005622	intracellular
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007009	plasma membrane organization
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q32M45	HS
# HGNC	HGNC:23837	ANO4
# InterPro	IPR007632	Anoctamin
# InterPro	IPR031293	Anoctamin-4
# InterPro	IPR032394	Anoct_dimer
# MIM	610111	gene
# MISCELLANEOUS	ANO4_HUMAN	The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology. 
# Organism	ANO4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12308	PTHR12308
# PANTHER	PTHR12308:SF28	PTHR12308:SF28
# Pfam	PF04547	Anoctamin
# Pfam	PF16178	Anoct_dimer
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	ANO4_HUMAN	Anoctamin-4
# RefSeq	NP_001273544	NM_001286615.1. [Q32M45-1]
# RefSeq	NP_001273545	NM_001286616.1. [Q32M45-1]
# RefSeq	NP_849148	NM_178826.3. [Q32M45-2]
# RefSeq	XP_011536216	XM_011537914.2. [Q32M45-2]
# RefSeq	XP_016874297	XM_017018808.1. [Q32M45-2]
# RefSeq	XP_016874298	XM_017018809.1. [Q32M45-1]
# RefSeq	XP_016874299	XM_017018810.1. [Q32M45-2]
# SEQUENCE CAUTION	Sequence=BAC03688.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the anoctamin family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	ANO4_HUMAN	Cell membrane {ECO 0000269|PubMed 22946059}; Multi-pass membrane protein {ECO 0000269|PubMed 22946059}. Note=Shows an intracellular localization. {ECO 0000250|UniProtKB Q8C5H1}. 
# UCSC	uc001thw	human. [Q32M45-1]
# eggNOG	ENOG410XS4S	LUCA
# eggNOG	KOG2514	Eukaryota
BLAST	swissprot:ANO4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ANO4_HUMAN
COXPRESdb	121601	http://coxpresdb.jp/data/gene/121601.shtml
CleanEx	HS_ANO4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ANO4
DOI	10.1007/s00424-011-0975-9	http://dx.doi.org/10.1007/s00424-011-0975-9
DOI	10.1038/aps.2011.48	http://dx.doi.org/10.1038/aps.2011.48
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1113/expphysiol.2011.058214	http://dx.doi.org/10.1113/expphysiol.2011.058214
DOI	10.1242/jcs.109553	http://dx.doi.org/10.1242/jcs.109553
EMBL	AK091540	http://www.ebi.ac.uk/ena/data/view/AK091540
EMBL	AK091591	http://www.ebi.ac.uk/ena/data/view/AK091591
EMBL	AK092596	http://www.ebi.ac.uk/ena/data/view/AK092596
EMBL	BC109308	http://www.ebi.ac.uk/ena/data/view/BC109308
Ensembl	ENST00000392977	http://www.ensembl.org/id/ENST00000392977
Ensembl	ENST00000392979	http://www.ensembl.org/id/ENST00000392979
Ensembl	ENST00000550015	http://www.ensembl.org/id/ENST00000550015
Ensembl	ENST00000570509	http://www.ensembl.org/id/ENST00000570509
Ensembl	ENST00000573650	http://www.ensembl.org/id/ENST00000573650
Ensembl	ENST00000575847	http://www.ensembl.org/id/ENST00000575847
Ensembl	ENST00000594618	http://www.ensembl.org/id/ENST00000594618
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005229	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005229
GO_function	GO:0017128	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017128
GO_process	GO:0006821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006821
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0061589	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061589
GO_process	GO:0061590	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061590
GO_process	GO:0061591	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061591
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007009
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ANO4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ANO4
GeneID	121601	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=121601
GeneTree	ENSGT00760000119015	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119015
HGNC	HGNC:23837	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:23837
HOGENOM	HOG000006509	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006509&db=HOGENOM6
HOVERGEN	HBG069519	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG069519&db=HOVERGEN
HPA	HPA053412	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA053412
InParanoid	Q32M45	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q32M45
InterPro	IPR007632	http://www.ebi.ac.uk/interpro/entry/IPR007632
InterPro	IPR031293	http://www.ebi.ac.uk/interpro/entry/IPR031293
InterPro	IPR032394	http://www.ebi.ac.uk/interpro/entry/IPR032394
Jabion	121601	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=121601
KEGG_Gene	hsa:121601	http://www.genome.jp/dbget-bin/www_bget?hsa:121601
MIM	610111	http://www.ncbi.nlm.nih.gov/omim/610111
OMA	HHILQRV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HHILQRV
OrthoDB	EOG091G01JF	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01JF
PANTHER	PTHR12308	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12308
PANTHER	PTHR12308:SF28	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12308:SF28
PSORT	swissprot:ANO4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ANO4_HUMAN
PSORT-B	swissprot:ANO4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ANO4_HUMAN
PSORT2	swissprot:ANO4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ANO4_HUMAN
Pfam	PF04547	http://pfam.xfam.org/family/PF04547
Pfam	PF16178	http://pfam.xfam.org/family/PF16178
PharmGKB	PA164715582	http://www.pharmgkb.org/do/serve?objId=PA164715582&objCls=Gene
Phobius	swissprot:ANO4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ANO4_HUMAN
PhylomeDB	Q32M45	http://phylomedb.org/?seqid=Q32M45
ProteinModelPortal	Q32M45	http://www.proteinmodelportal.org/query/uniprot/Q32M45
PubMed	12739008	http://www.ncbi.nlm.nih.gov/pubmed/12739008
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21607626	http://www.ncbi.nlm.nih.gov/pubmed/21607626
PubMed	21642943	http://www.ncbi.nlm.nih.gov/pubmed/21642943
PubMed	22302790	http://www.ncbi.nlm.nih.gov/pubmed/22302790
PubMed	22946059	http://www.ncbi.nlm.nih.gov/pubmed/22946059
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_001273544	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273544
RefSeq	NP_001273545	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273545
RefSeq	NP_849148	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_849148
RefSeq	XP_011536216	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011536216
RefSeq	XP_016874297	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016874297
RefSeq	XP_016874298	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016874298
RefSeq	XP_016874299	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016874299
SMR	Q32M45	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q32M45
STRING	9606.ENSP00000376705	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000376705&targetmode=cogs
UCSC	uc001thw	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001thw&org=rat
UniGene	Hs.58785	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.58785
UniProtKB	ANO4_HUMAN	http://www.uniprot.org/uniprot/ANO4_HUMAN
UniProtKB-AC	Q32M45	http://www.uniprot.org/uniprot/Q32M45
charge	swissprot:ANO4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ANO4_HUMAN
eggNOG	ENOG410XS4S	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS4S
eggNOG	KOG2514	http://eggnogapi.embl.de/nog_data/html/tree/KOG2514
epestfind	swissprot:ANO4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ANO4_HUMAN
garnier	swissprot:ANO4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ANO4_HUMAN
helixturnhelix	swissprot:ANO4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ANO4_HUMAN
hmoment	swissprot:ANO4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ANO4_HUMAN
iep	swissprot:ANO4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ANO4_HUMAN
inforesidue	swissprot:ANO4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ANO4_HUMAN
neXtProt	NX_Q32M45	http://www.nextprot.org/db/entry/NX_Q32M45
octanol	swissprot:ANO4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ANO4_HUMAN
pepcoil	swissprot:ANO4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ANO4_HUMAN
pepdigest	swissprot:ANO4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ANO4_HUMAN
pepinfo	swissprot:ANO4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ANO4_HUMAN
pepnet	swissprot:ANO4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ANO4_HUMAN
pepstats	swissprot:ANO4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ANO4_HUMAN
pepwheel	swissprot:ANO4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ANO4_HUMAN
pepwindow	swissprot:ANO4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ANO4_HUMAN
sigcleave	swissprot:ANO4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ANO4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	MOT5_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=O15374-1; Sequence=Displayed; Name=2; IsoId=O15374-2; Sequence=VSP_046242, VSP_046243; Note=No experimental confirmation available.; Name=3; IsoId=O15374-3; Sequence=VSP_046244; Note=No experimental confirmation available.; Name=4; IsoId=O15374-4; Sequence=VSP_046456, VSP_046458; Note=No experimental confirmation available.; Name=5; IsoId=O15374-5; Sequence=VSP_046457; Note=No experimental confirmation available.; 
# AltName	MOT5_HUMAN	Monocarboxylate transporter 4
# AltName	MOT5_HUMAN	Solute carrier family 16 member 4
# BioGrid	114570	2
# CCDS	CCDS55621	-. [O15374-4]
# CCDS	CCDS55622	-. [O15374-2]
# CCDS	CCDS55623	-. [O15374-5]
# CCDS	CCDS55624	-. [O15374-3]
# CCDS	CCDS823	-. [O15374-1]
# CDD	cd06174	MFS
# DrugBank	DB00119	Pyruvic acid
# Ensembl	ENST00000369779	ENSP00000358794; ENSG00000168679. [O15374-1]
# Ensembl	ENST00000369781	ENSP00000358796; ENSG00000168679. [O15374-3]
# Ensembl	ENST00000437429	ENSP00000394790; ENSG00000168679. [O15374-4]
# Ensembl	ENST00000472422	ENSP00000432495; ENSG00000168679. [O15374-5]
# Ensembl	ENST00000541986	ENSP00000446087; ENSG00000168679. [O15374-2]
# ExpressionAtlas	O15374	baseline and differential
# FUNCTION	MOT5_HUMAN	Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). {ECO 0000250}. 
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_function	GO:0008028	monocarboxylic acid transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0015129	lactate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_process	GO:0015718	monocarboxylic acid transport; TAS:ProtInc.
# GO_process	GO:0035879	plasma membrane lactate transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	O15374	HS
# HGNC	HGNC:10925	SLC16A4
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	603878	gene
# Organism	MOT5_HUMAN	Homo sapiens (Human)
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 1
# RecName	MOT5_HUMAN	Monocarboxylate transporter 5
# RefSeq	NP_001188475	NM_001201546.1. [O15374-5]
# RefSeq	NP_001188476	NM_001201547.1. [O15374-2]
# RefSeq	NP_001188477	NM_001201548.1. [O15374-4]
# RefSeq	NP_001188478	NM_001201549.1. [O15374-3]
# RefSeq	NP_004687	NM_004696.2. [O15374-1]
# RefSeq	XP_005271374	XM_005271317.4. [O15374-1]
# SIMILARITY	Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	MOT5_HUMAN	Cell membrane; Multi-pass membrane protein. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.1.13	the major facilitator superfamily (mfs)
# UCSC	uc001dzo	human. [O15374-1]
# eggNOG	ENOG410IMVW	Eukaryota
# eggNOG	ENOG410ZITK	LUCA
BLAST	swissprot:MOT5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MOT5_HUMAN
BioCyc	ZFISH:ENSG00000168679-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000168679-MONOMER
COXPRESdb	9122	http://coxpresdb.jp/data/gene/9122.shtml
CleanEx	HS_SLC16A4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC16A4
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/bj3290321	http://dx.doi.org/10.1042/bj3290321
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00119	http://www.drugbank.ca/drugs/DB00119
EMBL	AK290720	http://www.ebi.ac.uk/ena/data/view/AK290720
EMBL	AK295946	http://www.ebi.ac.uk/ena/data/view/AK295946
EMBL	AK298539	http://www.ebi.ac.uk/ena/data/view/AK298539
EMBL	AK313735	http://www.ebi.ac.uk/ena/data/view/AK313735
EMBL	AL355488	http://www.ebi.ac.uk/ena/data/view/AL355488
EMBL	AL355488	http://www.ebi.ac.uk/ena/data/view/AL355488
EMBL	BC021664	http://www.ebi.ac.uk/ena/data/view/BC021664
EMBL	CH471122	http://www.ebi.ac.uk/ena/data/view/CH471122
EMBL	CH471122	http://www.ebi.ac.uk/ena/data/view/CH471122
EMBL	CH471122	http://www.ebi.ac.uk/ena/data/view/CH471122
EMBL	U59185	http://www.ebi.ac.uk/ena/data/view/U59185
Ensembl	ENST00000369779	http://www.ensembl.org/id/ENST00000369779
Ensembl	ENST00000369781	http://www.ensembl.org/id/ENST00000369781
Ensembl	ENST00000437429	http://www.ensembl.org/id/ENST00000437429
Ensembl	ENST00000472422	http://www.ensembl.org/id/ENST00000472422
Ensembl	ENST00000541986	http://www.ensembl.org/id/ENST00000541986
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0008028	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008028
GO_function	GO:0015129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015129
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_process	GO:0015718	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015718
GO_process	GO:0035879	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035879
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC16A4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC16A4
GeneID	9122	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9122
GeneTree	ENSGT00760000118926	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118926
HGNC	HGNC:10925	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10925
HOGENOM	HOG000059591	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000059591&db=HOGENOM6
HOVERGEN	HBG006385	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006385&db=HOVERGEN
HPA	HPA046986	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA046986
InParanoid	O15374	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O15374
IntAct	O15374	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O15374*
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	9122	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9122
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:9122	http://www.genome.jp/dbget-bin/www_bget?hsa:9122
KEGG_Orthology	KO:K08181	http://www.genome.jp/dbget-bin/www_bget?KO:K08181
MIM	603878	http://www.ncbi.nlm.nih.gov/omim/603878
OMA	CVTMGFL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CVTMGFL
OrthoDB	EOG091G07PG	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07PG
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:MOT5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MOT5_HUMAN
PSORT-B	swissprot:MOT5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MOT5_HUMAN
PSORT2	swissprot:MOT5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MOT5_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA35816	http://www.pharmgkb.org/do/serve?objId=PA35816&objCls=Gene
Phobius	swissprot:MOT5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MOT5_HUMAN
PhylomeDB	O15374	http://phylomedb.org/?seqid=O15374
ProteinModelPortal	O15374	http://www.proteinmodelportal.org/query/uniprot/O15374
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	9425115	http://www.ncbi.nlm.nih.gov/pubmed/9425115
RefSeq	NP_001188475	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001188475
RefSeq	NP_001188476	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001188476
RefSeq	NP_001188477	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001188477
RefSeq	NP_001188478	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001188478
RefSeq	NP_004687	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004687
RefSeq	XP_005271374	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005271374
STRING	9606.ENSP00000358794	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000358794&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.13	http://www.tcdb.org/search/result.php?tc=2.A.1.13
UCSC	uc001dzo	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001dzo&org=rat
UniGene	Hs.351306	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.351306
UniProtKB	MOT5_HUMAN	http://www.uniprot.org/uniprot/MOT5_HUMAN
UniProtKB-AC	O15374	http://www.uniprot.org/uniprot/O15374
charge	swissprot:MOT5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MOT5_HUMAN
eggNOG	ENOG410IMVW	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IMVW
eggNOG	ENOG410ZITK	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZITK
epestfind	swissprot:MOT5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MOT5_HUMAN
garnier	swissprot:MOT5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MOT5_HUMAN
helixturnhelix	swissprot:MOT5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MOT5_HUMAN
hmoment	swissprot:MOT5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MOT5_HUMAN
iep	swissprot:MOT5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MOT5_HUMAN
inforesidue	swissprot:MOT5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MOT5_HUMAN
neXtProt	NX_O15374	http://www.nextprot.org/db/entry/NX_O15374
octanol	swissprot:MOT5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MOT5_HUMAN
pepcoil	swissprot:MOT5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MOT5_HUMAN
pepdigest	swissprot:MOT5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MOT5_HUMAN
pepinfo	swissprot:MOT5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MOT5_HUMAN
pepnet	swissprot:MOT5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MOT5_HUMAN
pepstats	swissprot:MOT5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MOT5_HUMAN
pepwheel	swissprot:MOT5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MOT5_HUMAN
pepwindow	swissprot:MOT5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MOT5_HUMAN
sigcleave	swissprot:MOT5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MOT5_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AP2A1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=A; IsoId=O95782-1; Sequence=Displayed; Name=B; IsoId=O95782-2; Sequence=VSP_000161; 
# AltName	AP2A1_HUMAN	100 kDa coated vesicle protein A
# AltName	AP2A1_HUMAN	Adaptor protein complex AP-2 subunit alpha-1
# AltName	AP2A1_HUMAN	Adaptor-related protein complex 2 subunit alpha-1
# AltName	AP2A1_HUMAN	Alpha-adaptin A
# AltName	AP2A1_HUMAN	Alpha1-adaptin
# AltName	AP2A1_HUMAN	Clathrin assembly protein complex 2 alpha-A large chain
# AltName	AP2A1_HUMAN	Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit
# BioGrid	106669	120
# CCDS	CCDS46148	-. [O95782-1]
# CCDS	CCDS46149	-. [O95782-2]
# ChiTaRS	AP2A1	human
# Ensembl	ENST00000354293	ENSP00000346246; ENSG00000196961. [O95782-2]
# Ensembl	ENST00000359032	ENSP00000351926; ENSG00000196961. [O95782-1]
# ExpressionAtlas	O95782	baseline and differential
# FUNCTION	AP2A1_HUMAN	Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C- terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). {ECO 0000250, ECO 0000269|PubMed 14745134, ECO 0000269|PubMed 15473838, ECO 0000269|PubMed 19033387}. 
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:Ensembl.
# GO_component	GO:0016324	apical plasma membrane; IEA:Ensembl.
# GO_component	GO:0030122	AP-2 adaptor complex; NAS:UniProtKB.
# GO_component	GO:0030130	clathrin coat of trans-Golgi network vesicle; NAS:UniProtKB.
# GO_component	GO:0030666	endocytic vesicle membrane; TAS:Reactome.
# GO_component	GO:0030669	clathrin-coated endocytic vesicle membrane; TAS:Reactome.
# GO_component	GO:0032433	filopodium tip; IEA:Ensembl.
# GO_component	GO:0036020	endolysosome membrane; TAS:Reactome.
# GO_function	GO:0008565	protein transporter activity; IEA:InterPro.
# GO_function	GO:0019901	protein kinase binding; ISS:ParkinsonsUK-UCL.
# GO_process	GO:0006886	intracellular protein transport; NAS:UniProtKB.
# GO_process	GO:0006895	Golgi to endosome transport; NAS:UniProtKB.
# GO_process	GO:0006897	endocytosis; NAS:UniProtKB.
# GO_process	GO:0007018	microtubule-based movement; TAS:Reactome.
# GO_process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
# GO_process	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0048013	ephrin receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0050690	regulation of defense response to virus by virus; TAS:Reactome.
# GO_process	GO:0060071	Wnt signaling pathway, planar cell polarity pathway; TAS:Reactome.
# GO_process	GO:0072583	clathrin-dependent endocytosis; TAS:BHF-UCL.
# GO_process	GO:1900126	negative regulation of hyaluronan biosynthetic process; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# Gene3D	1.25.10.10	-; 1.
# Gene3D	2.60.40.1030	-; 1.
# Gene3D	3.30.310.30	-; 1.
# Genevisible	O95782	HS
# HGNC	HGNC:561	AP2A1
# IntAct	O95782	67
# InterPro	IPR002553	Clathrin/coatomer_adapt-like_N
# InterPro	IPR003164	Clathrin_a-adaptin_app_sub_C
# InterPro	IPR008152	Clathrin_a/b/g-adaptin_app_Ig
# InterPro	IPR009028	Coatomer/calthrin_app_sub_C
# InterPro	IPR011989	ARM-like
# InterPro	IPR013038	Clathrin_a-adaptin_app_Ig-like
# InterPro	IPR013041	Coatomer/clathrin_app_Ig-like
# InterPro	IPR015873	Clathrin_a/coatomer_app_sub_C
# InterPro	IPR016024	ARM-type_fold
# InterPro	IPR017104	AP2_complex_asu
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Pathway	ko04144	Endocytosis
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04961	Endocrine and other factor-regulated calcium reabsorption
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	601026	gene
# Organism	AP2A1_HUMAN	Homo sapiens (Human)
# PIRSF	PIRSF037091	AP2_complex_alpha
# Pfam	PF01602	Adaptin_N
# Pfam	PF02296	Alpha_adaptin_C
# Pfam	PF02883	Alpha_adaptinC2
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-167590	Nef Mediated CD4 Down-regulation
# Reactome	R-HSA-171052	LDL-mediated lipid transport
# Reactome	R-HSA-177504	Retrograde neurotrophin signalling
# Reactome	R-HSA-182218	Nef Mediated CD8 Down-regulation
# Reactome	R-HSA-2132295	MHC class II antigen presentation
# Reactome	R-HSA-3928665	EPH-ephrin mediated repulsion of cells
# Reactome	R-HSA-416993	Trafficking of GluR2-containing AMPA receptors
# Reactome	R-HSA-437239	Recycling pathway of L1
# Reactome	R-HSA-5099900	WNT5A-dependent internalization of FZD4
# Reactome	R-HSA-5140745	WNT5A-dependent internalization of FZD2, FZD5 and ROR2
# Reactome	R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis
# Reactome	R-HSA-8856828	Clathrin-mediated endocytosis
# Reactome	R-HSA-8866427	VLDLR internalisation and degradation
# RecName	AP2A1_HUMAN	AP-2 complex subunit alpha-1
# RefSeq	NP_055018	NM_014203.2. [O95782-1]
# RefSeq	NP_570603	NM_130787.2. [O95782-2]
# SEQUENCE CAUTION	Sequence=AAD15564.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the adaptor complexes large subunit family. {ECO	0000305}. 
# SMART	SM00809	Alpha_adaptinC2
# SUBCELLULAR LOCATION	AP2A1_HUMAN	Cell membrane {ECO 0000250}. Membrane, coated pit {ECO 0000250}; Peripheral membrane protein {ECO 0000250}; Cytoplasmic side {ECO 0000250}. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. {ECO 0000250}. 
# SUBUNIT	AP2A1_HUMAN	Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1). Interacts with SGIP1 (By similarity). Interacts with HIP1 and RAB11FIP2. Interacts with SLC12A5. Interacts with clathrin. {ECO 0000250, ECO 0000269|PubMed 11532990, ECO 0000269|PubMed 12364336}. 
# SUPFAM	SSF48371	SSF48371
# SUPFAM	SSF49348	SSF49348
# SUPFAM	SSF55711	SSF55711
# TISSUE SPECIFICITY	AP2A1_HUMAN	Isoform A expressed in forebrain, skeletal muscle, spinal cord, cerebellum, salivary gland, heart and colon. Isoform B is widely expressed in tissues and also in breast cancer and in prostate carcinoma cells. 
# UCSC	uc002ppn	human. [O95782-1]
# eggNOG	ENOG410XNQE	LUCA
# eggNOG	KOG1077	Eukaryota
BLAST	swissprot:AP2A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AP2A1_HUMAN
BioCyc	ZFISH:G66-32740-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32740-MONOMER
COXPRESdb	160	http://coxpresdb.jp/data/gene/160.shtml
CleanEx	HS_AP2A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AP2A1
DIP	DIP-33164N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-33164N
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/S0378-1119(02)00504-8	http://dx.doi.org/10.1016/S0378-1119(02)00504-8
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/jbc.M206316200	http://dx.doi.org/10.1074/jbc.M206316200
DOI	10.1093/hmg/10.17.1807	http://dx.doi.org/10.1093/hmg/10.17.1807
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1101/gr.GR1547R	http://dx.doi.org/10.1101/gr.GR1547R
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1146/annurev.cellbio.20.010403.104543	http://dx.doi.org/10.1146/annurev.cellbio.20.010403.104543
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1242/jcs.033522	http://dx.doi.org/10.1242/jcs.033522
DOI	10.1247/csf.28.419	http://dx.doi.org/10.1247/csf.28.419
EMBL	AC006942	http://www.ebi.ac.uk/ena/data/view/AC006942
EMBL	AC011495	http://www.ebi.ac.uk/ena/data/view/AC011495
EMBL	AC098783	http://www.ebi.ac.uk/ena/data/view/AC098783
EMBL	AF289221	http://www.ebi.ac.uk/ena/data/view/AF289221
EMBL	AF289221	http://www.ebi.ac.uk/ena/data/view/AF289221
EMBL	AL136925	http://www.ebi.ac.uk/ena/data/view/AL136925
EMBL	BC014214	http://www.ebi.ac.uk/ena/data/view/BC014214
Ensembl	ENST00000354293	http://www.ensembl.org/id/ENST00000354293
Ensembl	ENST00000359032	http://www.ensembl.org/id/ENST00000359032
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0030122	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030122
GO_component	GO:0030130	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030130
GO_component	GO:0030666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030666
GO_component	GO:0030669	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030669
GO_component	GO:0032433	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032433
GO_component	GO:0036020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036020
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0019901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019901
GO_process	GO:0006886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006886
GO_process	GO:0006895	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006895
GO_process	GO:0006897	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006897
GO_process	GO:0007018	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007018
GO_process	GO:0019886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019886
GO_process	GO:0042059	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042059
GO_process	GO:0048013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048013
GO_process	GO:0050690	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050690
GO_process	GO:0060071	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060071
GO_process	GO:0072583	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072583
GO_process	GO:1900126	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900126
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
Gene3D	2.60.40.1030	http://www.cathdb.info/version/latest/superfamily/2.60.40.1030
Gene3D	3.30.310.30	http://www.cathdb.info/version/latest/superfamily/3.30.310.30
GeneCards	AP2A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=AP2A1
GeneID	160	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=160
GeneTree	ENSGT00550000074757	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074757
HGNC	HGNC:561	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:561
HOGENOM	HOG000170596	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000170596&db=HOGENOM6
HOVERGEN	HBG050518	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050518&db=HOVERGEN
HPA	CAB004306	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB004306
InParanoid	O95782	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O95782
IntAct	O95782	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O95782*
InterPro	IPR002553	http://www.ebi.ac.uk/interpro/entry/IPR002553
InterPro	IPR003164	http://www.ebi.ac.uk/interpro/entry/IPR003164
InterPro	IPR008152	http://www.ebi.ac.uk/interpro/entry/IPR008152
InterPro	IPR009028	http://www.ebi.ac.uk/interpro/entry/IPR009028
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR013038	http://www.ebi.ac.uk/interpro/entry/IPR013038
InterPro	IPR013041	http://www.ebi.ac.uk/interpro/entry/IPR013041
InterPro	IPR015873	http://www.ebi.ac.uk/interpro/entry/IPR015873
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
InterPro	IPR017104	http://www.ebi.ac.uk/interpro/entry/IPR017104
Jabion	160	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=160
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Gene	hsa:160	http://www.genome.jp/dbget-bin/www_bget?hsa:160
KEGG_Orthology	KO:K11824	http://www.genome.jp/dbget-bin/www_bget?KO:K11824
KEGG_Pathway	ko04144	http://www.genome.jp/kegg-bin/show_pathway?ko04144
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04961	http://www.genome.jp/kegg-bin/show_pathway?ko04961
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	601026	http://www.ncbi.nlm.nih.gov/omim/601026
MINT	MINT-5002322	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5002322
OMA	INIKFRY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=INIKFRY
OrthoDB	EOG091G01JZ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01JZ
PSORT	swissprot:AP2A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AP2A1_HUMAN
PSORT-B	swissprot:AP2A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AP2A1_HUMAN
PSORT2	swissprot:AP2A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AP2A1_HUMAN
Pfam	PF01602	http://pfam.xfam.org/family/PF01602
Pfam	PF02296	http://pfam.xfam.org/family/PF02296
Pfam	PF02883	http://pfam.xfam.org/family/PF02883
PharmGKB	PA24852	http://www.pharmgkb.org/do/serve?objId=PA24852&objCls=Gene
Phobius	swissprot:AP2A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AP2A1_HUMAN
PhylomeDB	O95782	http://phylomedb.org/?seqid=O95782
ProteinModelPortal	O95782	http://www.proteinmodelportal.org/query/uniprot/O95782
PubMed	11230166	http://www.ncbi.nlm.nih.gov/pubmed/11230166
PubMed	11532990	http://www.ncbi.nlm.nih.gov/pubmed/11532990
PubMed	12036598	http://www.ncbi.nlm.nih.gov/pubmed/12036598
PubMed	12364336	http://www.ncbi.nlm.nih.gov/pubmed/12364336
PubMed	14745134	http://www.ncbi.nlm.nih.gov/pubmed/14745134
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	15473838	http://www.ncbi.nlm.nih.gov/pubmed/15473838
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	19033387	http://www.ncbi.nlm.nih.gov/pubmed/19033387
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-167590	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-167590
Reactome	R-HSA-171052	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-171052
Reactome	R-HSA-177504	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-177504
Reactome	R-HSA-182218	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-182218
Reactome	R-HSA-2132295	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2132295
Reactome	R-HSA-3928665	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3928665
Reactome	R-HSA-416993	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-416993
Reactome	R-HSA-437239	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-437239
Reactome	R-HSA-5099900	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5099900
Reactome	R-HSA-5140745	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5140745
Reactome	R-HSA-8856825	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8856825
Reactome	R-HSA-8856828	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8856828
Reactome	R-HSA-8866427	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8866427
RefSeq	NP_055018	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055018
RefSeq	NP_570603	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_570603
SMART	SM00809	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00809
SMR	O95782	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O95782
STRING	9606.ENSP00000351926	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000351926&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
SUPFAM	SSF49348	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49348
SUPFAM	SSF55711	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55711
UCSC	uc002ppn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ppn&org=rat
UniGene	Hs.467125	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.467125
UniProtKB	AP2A1_HUMAN	http://www.uniprot.org/uniprot/AP2A1_HUMAN
UniProtKB-AC	O95782	http://www.uniprot.org/uniprot/O95782
charge	swissprot:AP2A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AP2A1_HUMAN
eggNOG	ENOG410XNQE	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNQE
eggNOG	KOG1077	http://eggnogapi.embl.de/nog_data/html/tree/KOG1077
epestfind	swissprot:AP2A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AP2A1_HUMAN
garnier	swissprot:AP2A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AP2A1_HUMAN
helixturnhelix	swissprot:AP2A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AP2A1_HUMAN
hmoment	swissprot:AP2A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AP2A1_HUMAN
iep	swissprot:AP2A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AP2A1_HUMAN
inforesidue	swissprot:AP2A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AP2A1_HUMAN
neXtProt	NX_O95782	http://www.nextprot.org/db/entry/NX_O95782
octanol	swissprot:AP2A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AP2A1_HUMAN
pepcoil	swissprot:AP2A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AP2A1_HUMAN
pepdigest	swissprot:AP2A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AP2A1_HUMAN
pepinfo	swissprot:AP2A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AP2A1_HUMAN
pepnet	swissprot:AP2A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AP2A1_HUMAN
pepstats	swissprot:AP2A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AP2A1_HUMAN
pepwheel	swissprot:AP2A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AP2A1_HUMAN
pepwindow	swissprot:AP2A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AP2A1_HUMAN
sigcleave	swissprot:AP2A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AP2A1_HUMAN
## Database	ID	URL or Descriptions
# AltName	ORAI3_HUMAN	Transmembrane protein 142C
# ChiTaRS	ORAI3	human
# Ensembl	ENST00000318663	ENSP00000322249; ENSG00000175938
# ExpressionAtlas	Q9BRQ5	baseline and differential
# FUNCTION	ORAI3_HUMAN	Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import. {ECO 0000250}. 
# GO_component	GO:0016020	membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015279	store-operated calcium channel activity; IBA:GO_Central.
# GO_process	GO:0002115	store-operated calcium entry; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q9BRQ5	HS
# HGNC	HGNC:28185	ORAI3
# INTERACTION	ORAI3_HUMAN	Q96D31 ORAI1; NbExp=3; IntAct=EBI-4279484, EBI-2291476; 
# IntAct	Q9BRQ5	2
# InterPro	IPR012446	CRAC_channel
# InterPro	IPR030032	Orai-3
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Pathway	ko04020	Calcium signaling pathway
# MIM	610930	gene
# Organism	ORAI3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR31501	PTHR31501; 2
# PANTHER	PTHR31501:SF6	PTHR31501:SF6; 2
# Pfam	PF07856	Orai-1
# Proteomes	UP000005640	Chromosome 16
# RecName	ORAI3_HUMAN	Protein orai-3
# RefSeq	NP_689501	NM_152288.2
# SIMILARITY	Belongs to the Orai family. {ECO	0000305}.
# SUBCELLULAR LOCATION	ORAI3_HUMAN	Membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUBUNIT	Interacts with CRACR2A/EFCAB4B. {ECO:0000269|PubMed	20418871}. 
# TCDB	1.A.52.1	the ca(2+) release-activated ca(2+) (crac) channel (crac-c) family
# UCSC	uc002eac	human
# eggNOG	ENOG4110DSB	LUCA
# eggNOG	KOG4298	Eukaryota
BLAST	swissprot:ORAI3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ORAI3_HUMAN
BioCyc	ZFISH:ENSG00000175938-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000175938-MONOMER
COXPRESdb	93129	http://coxpresdb.jp/data/gene/93129.shtml
CleanEx	HS_ORAI3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ORAI3
DIP	DIP-48945N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48945N
DOI	10.1038/nature04702	http://dx.doi.org/10.1038/nature04702
DOI	10.1038/ncb2045	http://dx.doi.org/10.1038/ncb2045
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	BC006126	http://www.ebi.ac.uk/ena/data/view/BC006126
EMBL	BC015555	http://www.ebi.ac.uk/ena/data/view/BC015555
EMBL	BC022786	http://www.ebi.ac.uk/ena/data/view/BC022786
Ensembl	ENST00000318663	http://www.ensembl.org/id/ENST00000318663
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015279	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015279
GO_process	GO:0002115	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002115
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	ORAI3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ORAI3
GeneID	93129	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=93129
GeneTree	ENSGT00390000015354	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000015354
HGNC	HGNC:28185	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:28185
HOGENOM	HOG000246925	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000246925&db=HOGENOM6
HOVERGEN	HBG081343	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG081343&db=HOVERGEN
HPA	HPA015022	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA015022
InParanoid	Q9BRQ5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9BRQ5
IntAct	Q9BRQ5	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9BRQ5*
InterPro	IPR012446	http://www.ebi.ac.uk/interpro/entry/IPR012446
InterPro	IPR030032	http://www.ebi.ac.uk/interpro/entry/IPR030032
Jabion	93129	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=93129
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Gene	hsa:93129	http://www.genome.jp/dbget-bin/www_bget?hsa:93129
KEGG_Orthology	KO:K16058	http://www.genome.jp/dbget-bin/www_bget?KO:K16058
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
MIM	610930	http://www.ncbi.nlm.nih.gov/omim/610930
OMA	SATYRDF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SATYRDF
OrthoDB	EOG091G0E4P	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0E4P
PANTHER	PTHR31501	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31501
PANTHER	PTHR31501:SF6	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31501:SF6
PSORT	swissprot:ORAI3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ORAI3_HUMAN
PSORT-B	swissprot:ORAI3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ORAI3_HUMAN
PSORT2	swissprot:ORAI3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ORAI3_HUMAN
Pfam	PF07856	http://pfam.xfam.org/family/PF07856
PharmGKB	PA162398465	http://www.pharmgkb.org/do/serve?objId=PA162398465&objCls=Gene
Phobius	swissprot:ORAI3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ORAI3_HUMAN
PhylomeDB	Q9BRQ5	http://phylomedb.org/?seqid=Q9BRQ5
ProteinModelPortal	Q9BRQ5	http://www.proteinmodelportal.org/query/uniprot/Q9BRQ5
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16582901	http://www.ncbi.nlm.nih.gov/pubmed/16582901
PubMed	20418871	http://www.ncbi.nlm.nih.gov/pubmed/20418871
RefSeq	NP_689501	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_689501
STRING	9606.ENSP00000322249	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000322249&targetmode=cogs
TCDB	1.A.52.1	http://www.tcdb.org/search/result.php?tc=1.A.52.1
UCSC	uc002eac	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002eac&org=rat
UniGene	Hs.745104	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.745104
UniProtKB	ORAI3_HUMAN	http://www.uniprot.org/uniprot/ORAI3_HUMAN
UniProtKB-AC	Q9BRQ5	http://www.uniprot.org/uniprot/Q9BRQ5
charge	swissprot:ORAI3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ORAI3_HUMAN
eggNOG	ENOG4110DSB	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110DSB
eggNOG	KOG4298	http://eggnogapi.embl.de/nog_data/html/tree/KOG4298
epestfind	swissprot:ORAI3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ORAI3_HUMAN
garnier	swissprot:ORAI3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ORAI3_HUMAN
helixturnhelix	swissprot:ORAI3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ORAI3_HUMAN
hmoment	swissprot:ORAI3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ORAI3_HUMAN
iep	swissprot:ORAI3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ORAI3_HUMAN
inforesidue	swissprot:ORAI3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ORAI3_HUMAN
neXtProt	NX_Q9BRQ5	http://www.nextprot.org/db/entry/NX_Q9BRQ5
octanol	swissprot:ORAI3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ORAI3_HUMAN
pepcoil	swissprot:ORAI3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ORAI3_HUMAN
pepdigest	swissprot:ORAI3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ORAI3_HUMAN
pepinfo	swissprot:ORAI3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ORAI3_HUMAN
pepnet	swissprot:ORAI3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ORAI3_HUMAN
pepstats	swissprot:ORAI3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ORAI3_HUMAN
pepwheel	swissprot:ORAI3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ORAI3_HUMAN
pepwindow	swissprot:ORAI3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ORAI3_HUMAN
sigcleave	swissprot:ORAI3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ORAI3_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNJ6_HUMAN	BIR1
# AltName	KCNJ6_HUMAN	Inward rectifier K(+) channel Kir3.2
# AltName	KCNJ6_HUMAN	KATP-2
# AltName	KCNJ6_HUMAN	Potassium channel, inwardly rectifying subfamily J member 6
# BioGrid	109965	13
# ChiTaRS	KCNJ6	human
# DISEASE	KCNJ6_HUMAN	Keppen-Lubinsky syndrome (KPLBS) [MIM 614098]  A rare disease characterized by severe developmental delay, intellectual disability, severe generalized lipodystrophy, dysmorphic features including microcephaly, large prominent eyes, narrow nasal bridge, tented upper lip, high palate, open mouth, tightly adherent skin, and aged appearance. {ECO 0000269|PubMed 25620207}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00898	Ethanol
# DrugBank	DB01159	Halothane
# Ensembl	ENST00000609713	ENSP00000477437; ENSG00000157542
# FUNCTION	KCNJ6_HUMAN	This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. 
# GO_component	GO:0005794	Golgi apparatus; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0008076	voltage-gated potassium channel complex; TAS:ProtInc.
# GO_function	GO:0005242	inward rectifier potassium channel activity; TAS:ProtInc.
# GO_function	GO:0015467	G-protein activated inward rectifier potassium channel activity; TAS:Reactome.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0010107	potassium ion import; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.40.1400	-; 1.
# Genevisible	P48051	HS
# HGNC	HGNC:6267	KCNJ6
# InterPro	IPR003275	K_chnl_inward-rec_Kir3.2
# InterPro	IPR013518	K_chnl_inward-rec_Kir_cyto
# InterPro	IPR014756	Ig_E-set
# InterPro	IPR016449	K_chnl_inward-rec_Kir
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04713	Circadian entrainment
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04725	Cholinergic synapse
# KEGG_Pathway	ko04726	Serotonergic synapse
# KEGG_Pathway	ko04727	GABAergic synapse
# KEGG_Pathway	ko04728	Dopaminergic synapse
# KEGG_Pathway	ko05032	Morphine addiction
# MIM	600877	gene
# MIM	614098	phenotype
# Organism	KCNJ6_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11767	PTHR11767
# PANTHER	PTHR11767:SF19	PTHR11767:SF19
# PIR	I38979	I38979
# PIRSF	PIRSF005465	GIRK_kir
# PRINTS	PR01320	KIRCHANNEL
# PRINTS	PR01328	KIR32CHANNEL
# Pfam	PF01007	IRK
# Proteomes	UP000005640	Chromosome 21
# Reactome	R-HSA-1296041	Activation of G protein gated Potassium channels
# Reactome	R-HSA-997272	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
# RecName	KCNJ6_HUMAN	G protein-activated inward rectifier potassium channel 2
# RefSeq	NP_002231	NM_002240.4
# SIMILARITY	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCNJ6_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Associates with GIRK1 or GIRK4 to form a G-protein- activated heteromultimer pore-forming unit. The resulting inward current is much larger. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane (By similarity). {ECO	0000250}. 
# SUPFAM	SSF81296	SSF81296
# TCDB	1.A.2.1.10	inward rectifier k(+) channel (irk-c) family
# TISSUE SPECIFICITY	KCNJ6_HUMAN	Most abundant in cerebellum, and to a lesser degree in islets and exocrine pancreas. 
# UCSC	uc002ywn	human
# eggNOG	ENOG410XQ62	LUCA
# eggNOG	KOG3827	Eukaryota
BLAST	swissprot:KCNJ6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNJ6_HUMAN
BioCyc	ZFISH:ENSG00000157542-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000157542-MONOMER
COXPRESdb	3763	http://coxpresdb.jp/data/gene/3763.shtml
CleanEx	HS_KCNJ6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNJ6
DOI	10.1016/0014-5793(95)00498-X	http://dx.doi.org/10.1016/0014-5793(95)00498-X
DOI	10.1016/S0898-6568(99)00059-5	http://dx.doi.org/10.1016/S0898-6568(99)00059-5
DOI	10.1016/j.ajhg.2014.12.011	http://dx.doi.org/10.1016/j.ajhg.2014.12.011
DOI	10.1074/jbc.270.44.26086	http://dx.doi.org/10.1074/jbc.270.44.26086
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.2337/diab.44.5.592	http://dx.doi.org/10.2337/diab.44.5.592
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01159	http://www.drugbank.ca/drugs/DB01159
EMBL	BC101547	http://www.ebi.ac.uk/ena/data/view/BC101547
EMBL	D87327	http://www.ebi.ac.uk/ena/data/view/D87327
EMBL	G02354	http://www.ebi.ac.uk/ena/data/view/G02354
EMBL	L78480	http://www.ebi.ac.uk/ena/data/view/L78480
EMBL	S78684	http://www.ebi.ac.uk/ena/data/view/S78684
EMBL	S78685	http://www.ebi.ac.uk/ena/data/view/S78685
EMBL	U24660	http://www.ebi.ac.uk/ena/data/view/U24660
EMBL	U52153	http://www.ebi.ac.uk/ena/data/view/U52153
Ensembl	ENST00000609713	http://www.ensembl.org/id/ENST00000609713
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_function	GO:0005242	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005242
GO_function	GO:0015467	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015467
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0010107	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010107
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.40.1400	http://www.cathdb.info/version/latest/superfamily/2.60.40.1400
GeneCards	KCNJ6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNJ6
GeneID	3763	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3763
GeneTree	ENSGT00760000118842	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118842
HGNC	HGNC:6267	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6267
HOGENOM	HOG000237325	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237325&db=HOGENOM6
HOVERGEN	HBG006178	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006178&db=HOVERGEN
HPA	CAB012452	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB012452
InParanoid	P48051	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P48051
InterPro	IPR003275	http://www.ebi.ac.uk/interpro/entry/IPR003275
InterPro	IPR013518	http://www.ebi.ac.uk/interpro/entry/IPR013518
InterPro	IPR014756	http://www.ebi.ac.uk/interpro/entry/IPR014756
InterPro	IPR016449	http://www.ebi.ac.uk/interpro/entry/IPR016449
Jabion	3763	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3763
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3763	http://www.genome.jp/dbget-bin/www_bget?hsa:3763
KEGG_Orthology	KO:K05000	http://www.genome.jp/dbget-bin/www_bget?KO:K05000
KEGG_Pathway	ko04713	http://www.genome.jp/kegg-bin/show_pathway?ko04713
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04725	http://www.genome.jp/kegg-bin/show_pathway?ko04725
KEGG_Pathway	ko04726	http://www.genome.jp/kegg-bin/show_pathway?ko04726
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
KEGG_Pathway	ko04728	http://www.genome.jp/kegg-bin/show_pathway?ko04728
KEGG_Pathway	ko05032	http://www.genome.jp/kegg-bin/show_pathway?ko05032
MIM	600877	http://www.ncbi.nlm.nih.gov/omim/600877
MIM	614098	http://www.ncbi.nlm.nih.gov/omim/614098
OMA	TIHQPKL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TIHQPKL
OrthoDB	EOG091G08HC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08HC
PANTHER	PTHR11767	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11767
PANTHER	PTHR11767:SF19	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11767:SF19
PRINTS	PR01320	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01320
PRINTS	PR01328	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01328
PSORT	swissprot:KCNJ6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNJ6_HUMAN
PSORT-B	swissprot:KCNJ6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNJ6_HUMAN
PSORT2	swissprot:KCNJ6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNJ6_HUMAN
Pfam	PF01007	http://pfam.xfam.org/family/PF01007
PharmGKB	PA30049	http://www.pharmgkb.org/do/serve?objId=PA30049&objCls=Gene
Phobius	swissprot:KCNJ6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNJ6_HUMAN
PhylomeDB	P48051	http://phylomedb.org/?seqid=P48051
ProteinModelPortal	P48051	http://www.proteinmodelportal.org/query/uniprot/P48051
PubMed	10659995	http://www.ncbi.nlm.nih.gov/pubmed/10659995
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	25620207	http://www.ncbi.nlm.nih.gov/pubmed/25620207
PubMed	7592809	http://www.ncbi.nlm.nih.gov/pubmed/7592809
PubMed	7729621	http://www.ncbi.nlm.nih.gov/pubmed/7729621
PubMed	7796919	http://www.ncbi.nlm.nih.gov/pubmed/7796919
Reactome	R-HSA-1296041	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296041
Reactome	R-HSA-997272	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-997272
RefSeq	NP_002231	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002231
SMR	P48051	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P48051
STRING	9606.ENSP00000288309	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000288309&targetmode=cogs
SUPFAM	SSF81296	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81296
TCDB	1.A.2.1.10	http://www.tcdb.org/search/result.php?tc=1.A.2.1.10
UCSC	uc002ywn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ywn&org=rat
UniGene	Hs.626242	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.626242
UniGene	Hs.658533	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.658533
UniGene	Hs.741904	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.741904
UniProtKB	KCNJ6_HUMAN	http://www.uniprot.org/uniprot/KCNJ6_HUMAN
UniProtKB-AC	P48051	http://www.uniprot.org/uniprot/P48051
charge	swissprot:KCNJ6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNJ6_HUMAN
eggNOG	ENOG410XQ62	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ62
eggNOG	KOG3827	http://eggnogapi.embl.de/nog_data/html/tree/KOG3827
epestfind	swissprot:KCNJ6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNJ6_HUMAN
garnier	swissprot:KCNJ6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNJ6_HUMAN
helixturnhelix	swissprot:KCNJ6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNJ6_HUMAN
hmoment	swissprot:KCNJ6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNJ6_HUMAN
iep	swissprot:KCNJ6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNJ6_HUMAN
inforesidue	swissprot:KCNJ6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNJ6_HUMAN
neXtProt	NX_P48051	http://www.nextprot.org/db/entry/NX_P48051
octanol	swissprot:KCNJ6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNJ6_HUMAN
pepcoil	swissprot:KCNJ6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNJ6_HUMAN
pepdigest	swissprot:KCNJ6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNJ6_HUMAN
pepinfo	swissprot:KCNJ6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNJ6_HUMAN
pepnet	swissprot:KCNJ6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNJ6_HUMAN
pepstats	swissprot:KCNJ6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNJ6_HUMAN
pepwheel	swissprot:KCNJ6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNJ6_HUMAN
pepwindow	swissprot:KCNJ6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNJ6_HUMAN
sigcleave	swissprot:KCNJ6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNJ6_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SAMC_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q70HW3-1; Sequence=Displayed; Name=2; IsoId=Q70HW3-2; Sequence=VSP_031062; Name=3; IsoId=Q70HW3-3; Sequence=VSP_031062, VSP_031063, VSP_031064; Note=No experimental confirmation available.; 
# AltName	SAMC_HUMAN	Mitochondrial S-adenosylmethionine transporter
# AltName	SAMC_HUMAN	Solute carrier family 25 member 26
# BioGrid	125423	3
# CCDS	CCDS2905	-. [Q70HW3-1]
# CCDS	CCDS54604	-. [Q70HW3-2]
# ChiTaRS	SLC25A26	human
# DISEASE	SAMC_HUMAN	Combined oxidative phosphorylation deficiency 28 (COXPD28) [MIM 616794]  An autosomal recessive mitochondrial disorder characterized by decreased activities of respiratory chain enzymes, and variable clinical manifestations. Clinical features include episodic metabolic decompensation beginning in infancy, mild muscle weakness, cardiorespiratory insufficiency, developmental delay, or even death. {ECO 0000269|PubMed 26522469}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# ENZYME REGULATION	Strongly inhibited by tannic acid and Bromocresol Purple. {ECO:0000269|PubMed	14674884}. 
# Ensembl	ENST00000336733	ENSP00000336801; ENSG00000144741. [Q70HW3-2]
# Ensembl	ENST00000632575	ENSP00000488865; ENSG00000282739. [Q70HW3-2]
# ExpressionAtlas	Q70HW3	baseline and differential
# FUNCTION	SAMC_HUMAN	Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S- adenosylmethionine (SAM) into the mitochondria. {ECO 0000269|PubMed 14674884, ECO 0000269|PubMed 26522469}. 
# GO_component	GO:0005739	mitochondrion; IDA:HPA.
# GO_component	GO:0005743	mitochondrial inner membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0000095	S-adenosyl-L-methionine transmembrane transporter activity; IMP:UniProtKB.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0015805	S-adenosyl-L-methionine transport; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Gene3D	1.50.40.10	-; 1.
# Genevisible	Q70HW3	HS
# HGNC	HGNC:20661	SLC25A26
# InterPro	IPR018108	Mitochondrial_sb/sol_carrier
# InterPro	IPR023395	Mt_carrier_dom
# KEGG_Brite	ko02001	Solute carrier family
# MIM	611037	gene
# MIM	616794	phenotype
# Organism	SAMC_HUMAN	Homo sapiens (Human)
# PROSITE	PS50920	SOLCAR; 3
# Pfam	PF00153	Mito_carr; 3
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-425393	Transport of inorganic cations/anions and amino acids/oligopeptides
# RecName	SAMC_HUMAN	S-adenosylmethionine mitochondrial carrier protein
# RefSeq	NP_001158268	NM_001164796.1. [Q70HW3-2]
# RefSeq	NP_775742	NM_173471.3
# RefSeq	XP_011531629	XM_011533327.2. [Q70HW3-2]
# SIMILARITY	Belongs to the mitochondrial carrier (TC 2.A.29) family. {ECO	0000305}. 
# SIMILARITY	Contains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule	PRU00282}.
# SUBCELLULAR LOCATION	SAMC_HUMAN	Mitochondrion inner membrane {ECO 0000269|PubMed 14674884}; Multi-pass membrane protein {ECO 0000269|PubMed 14674884}. 
# SUPFAM	SSF103506	SSF103506
# TCDB	2.A.29.18	the mitochondrial carrier (mc) family
# TISSUE SPECIFICITY	Widely expressed. Highly expressed in testis, with moderate expression in brain, heart, kidney, lung, skeletal muscle, pancreas, small intestine and liver, and low expression in spleen. {ECO:0000269|PubMed	14674884}. 
# UCSC	uc011bfs	human. [Q70HW3-1]
# eggNOG	ENOG4110BII	LUCA
# eggNOG	KOG0768	Eukaryota
BLAST	swissprot:SAMC_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SAMC_HUMAN
COXPRESdb	115286	http://coxpresdb.jp/data/gene/115286.shtml
CleanEx	HS_SLC25A26	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC25A26
DOI	10.1016/j.ajhg.2015.09.013	http://dx.doi.org/10.1016/j.ajhg.2015.09.013
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/BJ20031664	http://dx.doi.org/10.1042/BJ20031664
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AJ580932	http://www.ebi.ac.uk/ena/data/view/AJ580932
EMBL	AK092495	http://www.ebi.ac.uk/ena/data/view/AK092495
EMBL	AK096876	http://www.ebi.ac.uk/ena/data/view/AK096876
EMBL	AK291873	http://www.ebi.ac.uk/ena/data/view/AK291873
EMBL	BC003399	http://www.ebi.ac.uk/ena/data/view/BC003399
EMBL	BC012852	http://www.ebi.ac.uk/ena/data/view/BC012852
EMBL	CH471055	http://www.ebi.ac.uk/ena/data/view/CH471055
EMBL	CH471055	http://www.ebi.ac.uk/ena/data/view/CH471055
Ensembl	ENST00000336733	http://www.ensembl.org/id/ENST00000336733
Ensembl	ENST00000632575	http://www.ensembl.org/id/ENST00000632575
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0000095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000095
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0015805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015805
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
Gene3D	1.50.40.10	http://www.cathdb.info/version/latest/superfamily/1.50.40.10
GeneCards	SLC25A26	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC25A26
GeneID	115286	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=115286
GeneTree	ENSGT00550000074950	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074950
HGNC	HGNC:20661	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20661
HOGENOM	HOG000038810	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000038810&db=HOGENOM6
HOVERGEN	HBG108456	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108456&db=HOVERGEN
HPA	HPA026887	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA026887
InParanoid	Q70HW3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q70HW3
InterPro	IPR018108	http://www.ebi.ac.uk/interpro/entry/IPR018108
InterPro	IPR023395	http://www.ebi.ac.uk/interpro/entry/IPR023395
Jabion	115286	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=115286
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:115286	http://www.genome.jp/dbget-bin/www_bget?hsa:115286
KEGG_Orthology	KO:K15111	http://www.genome.jp/dbget-bin/www_bget?KO:K15111
MIM	611037	http://www.ncbi.nlm.nih.gov/omim/611037
MIM	616794	http://www.ncbi.nlm.nih.gov/omim/616794
PROSITE	PS50920	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50920
PSORT	swissprot:SAMC_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SAMC_HUMAN
PSORT-B	swissprot:SAMC_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SAMC_HUMAN
PSORT2	swissprot:SAMC_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SAMC_HUMAN
Pfam	PF00153	http://pfam.xfam.org/family/PF00153
PharmGKB	PA134987831	http://www.pharmgkb.org/do/serve?objId=PA134987831&objCls=Gene
Phobius	swissprot:SAMC_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SAMC_HUMAN
PhylomeDB	Q70HW3	http://phylomedb.org/?seqid=Q70HW3
ProteinModelPortal	Q70HW3	http://www.proteinmodelportal.org/query/uniprot/Q70HW3
PubMed	14674884	http://www.ncbi.nlm.nih.gov/pubmed/14674884
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	26522469	http://www.ncbi.nlm.nih.gov/pubmed/26522469
Reactome	R-HSA-425393	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425393
RefSeq	NP_001158268	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001158268
RefSeq	NP_775742	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_775742
RefSeq	XP_011531629	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011531629
STRING	9606.ENSP00000336801	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000336801&targetmode=cogs
SUPFAM	SSF103506	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103506
TCDB	2.A.29.18	http://www.tcdb.org/search/result.php?tc=2.A.29.18
UCSC	uc011bfs	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc011bfs&org=rat
UniGene	Hs.379386	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.379386
UniProtKB	SAMC_HUMAN	http://www.uniprot.org/uniprot/SAMC_HUMAN
UniProtKB-AC	Q70HW3	http://www.uniprot.org/uniprot/Q70HW3
charge	swissprot:SAMC_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SAMC_HUMAN
eggNOG	ENOG4110BII	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110BII
eggNOG	KOG0768	http://eggnogapi.embl.de/nog_data/html/tree/KOG0768
epestfind	swissprot:SAMC_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SAMC_HUMAN
garnier	swissprot:SAMC_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SAMC_HUMAN
helixturnhelix	swissprot:SAMC_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SAMC_HUMAN
hmoment	swissprot:SAMC_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SAMC_HUMAN
iep	swissprot:SAMC_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SAMC_HUMAN
inforesidue	swissprot:SAMC_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SAMC_HUMAN
neXtProt	NX_Q70HW3	http://www.nextprot.org/db/entry/NX_Q70HW3
octanol	swissprot:SAMC_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SAMC_HUMAN
pepcoil	swissprot:SAMC_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SAMC_HUMAN
pepdigest	swissprot:SAMC_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SAMC_HUMAN
pepinfo	swissprot:SAMC_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SAMC_HUMAN
pepnet	swissprot:SAMC_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SAMC_HUMAN
pepstats	swissprot:SAMC_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SAMC_HUMAN
pepwheel	swissprot:SAMC_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SAMC_HUMAN
pepwindow	swissprot:SAMC_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SAMC_HUMAN
sigcleave	swissprot:SAMC_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SAMC_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNV2_HUMAN	Voltage-gated potassium channel subunit Kv8.2
# BioGrid	127982	6
# DISEASE	KCNV2_HUMAN	Cone dystrophy retinal 3B (RCD3B) [MIM 610356]  A rare form of cone dystrophy associated with supernormal rod responses. The disorder is characterized by reduced visual acuity, photoaversion, night blindness, and abnormal color vision. At an early age, the retina shows subtle depigmentation at the macula and, later, more obvious areas of atrophy. {ECO 0000269|PubMed 16909397}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	KCNV2_HUMAN	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. 
# Ensembl	ENST00000382082	ENSP00000371514; ENSG00000168263
# FUNCTION	KCNV2_HUMAN	Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IEA:InterPro.
# GO_component	GO:0016021	integral component of membrane; IBA:GO_Central.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; IBA:GO_Central.
# GO_process	GO:0051260	protein homooligomerization; IEA:InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# Gene3D	1.20.120.350	-; 1.
# Genevisible	Q8TDN2	HS
# HGNC	HGNC:19698	KCNV2
# InterPro	IPR003131	T1-type_BTB
# InterPro	IPR003968	K_chnl_volt-dep_Kv
# InterPro	IPR003971	K_chnl_volt-dep_Kv9
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR011333	SKP1/BTB/POZ
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko04040	Ion channels
# KEGG_Disease	H00481	[Inherited metabolic disease; Nervous system disease; Eye disease] Retinal cone dystrophy (RCD)
# MIM	607604	gene
# MIM	610356	phenotype
# Organism	KCNV2_HUMAN	Homo sapiens (Human)
# Orphanet	209932	Cone dystrophy with supernormal rod response
# PANTHER	PTHR11537	PTHR11537; 2
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01491	KVCHANNEL
# PRINTS	PR01494	KV9CHANNEL
# Pfam	PF00520	Ion_trans
# Pfam	PF02214	BTB_2
# Proteomes	UP000005640	Chromosome 9
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# RecName	KCNV2_HUMAN	Potassium voltage-gated channel subfamily V member 2
# RefSeq	NP_598004	NM_133497.3
# SIMILARITY	Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.2/KCNV2 sub-subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCNV2_HUMAN	Cell membrane; Multi-pass membrane protein. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1. 
# SUBUNIT	Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers. {ECO:0000269|PubMed	12060745}. 
# SUPFAM	SSF54695	SSF54695
# TISSUE SPECIFICITY	Detected in lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary and colon. {ECO:0000269|PubMed	12060745}. 
# UCSC	uc003zho	human
# eggNOG	COG1226	LUCA
# eggNOG	KOG3713	Eukaryota
BLAST	swissprot:KCNV2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNV2_HUMAN
BioCyc	ZFISH:ENSG00000168263-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000168263-MONOMER
COXPRESdb	169522	http://coxpresdb.jp/data/gene/169522.shtml
CleanEx	HS_KCNV2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNV2
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
DOI	10.1073/pnas.122617999	http://dx.doi.org/10.1073/pnas.122617999
DOI	10.1086/507568	http://dx.doi.org/10.1086/507568
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF348983	http://www.ebi.ac.uk/ena/data/view/AF348983
EMBL	AL354723	http://www.ebi.ac.uk/ena/data/view/AL354723
EMBL	BC101352	http://www.ebi.ac.uk/ena/data/view/BC101352
EMBL	BC101353	http://www.ebi.ac.uk/ena/data/view/BC101353
Ensembl	ENST00000382082	http://www.ensembl.org/id/ENST00000382082
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	KCNV2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNV2
GeneID	169522	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=169522
GeneTree	ENSGT00760000118981	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118981
H-InvDB	HIX0035118	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0035118
HGNC	HGNC:19698	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:19698
HOGENOM	HOG000231016	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231016&db=HOGENOM6
HOVERGEN	HBG095321	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG095321&db=HOVERGEN
HPA	HPA031131	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031131
InParanoid	Q8TDN2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8TDN2
IntAct	Q8TDN2	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8TDN2*
InterPro	IPR003131	http://www.ebi.ac.uk/interpro/entry/IPR003131
InterPro	IPR003968	http://www.ebi.ac.uk/interpro/entry/IPR003968
InterPro	IPR003971	http://www.ebi.ac.uk/interpro/entry/IPR003971
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR011333	http://www.ebi.ac.uk/interpro/entry/IPR011333
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	169522	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=169522
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00481	http://www.genome.jp/dbget-bin/www_bget?H00481
KEGG_Gene	hsa:169522	http://www.genome.jp/dbget-bin/www_bget?hsa:169522
KEGG_Orthology	KO:K04935	http://www.genome.jp/dbget-bin/www_bget?KO:K04935
MIM	607604	http://www.ncbi.nlm.nih.gov/omim/607604
MIM	610356	http://www.ncbi.nlm.nih.gov/omim/610356
OMA	FQLIYNF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FQLIYNF
Orphanet	209932	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=209932
OrthoDB	EOG091G0FP3	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0FP3
PANTHER	PTHR11537	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01491	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01491
PRINTS	PR01494	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01494
PSORT	swissprot:KCNV2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNV2_HUMAN
PSORT-B	swissprot:KCNV2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNV2_HUMAN
PSORT2	swissprot:KCNV2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNV2_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF02214	http://pfam.xfam.org/family/PF02214
PharmGKB	PA134992655	http://www.pharmgkb.org/do/serve?objId=PA134992655&objCls=Gene
Phobius	swissprot:KCNV2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNV2_HUMAN
PhylomeDB	Q8TDN2	http://phylomedb.org/?seqid=Q8TDN2
ProteinModelPortal	Q8TDN2	http://www.proteinmodelportal.org/query/uniprot/Q8TDN2
PubMed	12060745	http://www.ncbi.nlm.nih.gov/pubmed/12060745
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16909397	http://www.ncbi.nlm.nih.gov/pubmed/16909397
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
RefSeq	NP_598004	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_598004
STRING	9606.ENSP00000371514	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000371514&targetmode=cogs
SUPFAM	SSF54695	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54695
UCSC	uc003zho	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003zho&org=rat
UniGene	Hs.622675	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.622675
UniGene	Hs.624689	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.624689
UniGene	Hs.740173	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.740173
UniProtKB	KCNV2_HUMAN	http://www.uniprot.org/uniprot/KCNV2_HUMAN
UniProtKB-AC	Q8TDN2	http://www.uniprot.org/uniprot/Q8TDN2
charge	swissprot:KCNV2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNV2_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG3713	http://eggnogapi.embl.de/nog_data/html/tree/KOG3713
epestfind	swissprot:KCNV2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNV2_HUMAN
garnier	swissprot:KCNV2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNV2_HUMAN
helixturnhelix	swissprot:KCNV2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNV2_HUMAN
hmoment	swissprot:KCNV2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNV2_HUMAN
iep	swissprot:KCNV2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNV2_HUMAN
inforesidue	swissprot:KCNV2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNV2_HUMAN
neXtProt	NX_Q8TDN2	http://www.nextprot.org/db/entry/NX_Q8TDN2
octanol	swissprot:KCNV2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNV2_HUMAN
pepcoil	swissprot:KCNV2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNV2_HUMAN
pepdigest	swissprot:KCNV2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNV2_HUMAN
pepinfo	swissprot:KCNV2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNV2_HUMAN
pepnet	swissprot:KCNV2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNV2_HUMAN
pepstats	swissprot:KCNV2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNV2_HUMAN
pepwheel	swissprot:KCNV2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNV2_HUMAN
pepwindow	swissprot:KCNV2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNV2_HUMAN
sigcleave	swissprot:KCNV2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNV2_HUMAN
## Database	ID	URL or Descriptions
# AltName	ABCA4_HUMAN	ATP-binding cassette sub-family A member 4
# AltName	ABCA4_HUMAN	RIM ABC transporter
# AltName	ABCA4_HUMAN	Stargardt disease protein
# ChiTaRS	ABCA4	human
# DISEASE	ABCA4_HUMAN	Cone-rod dystrophy 3 (CORD3) [MIM 604116]  An inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa. {ECO 0000269|PubMed 10958761, ECO 0000269|PubMed 11385708, ECO 0000269|PubMed 11527935}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ABCA4_HUMAN	Fundus flavimaculatus (FFM) [MIM 248200]  Autosomal recessive retinal disorder very similar to Stargardt disease. In contrast to Stargardt disease, FFM is characterized by later onset and slowly progressive course. {ECO 0000269|PubMed 11379881, ECO 0000269|PubMed 11385708, ECO 0000269|PubMed 9781034}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ABCA4_HUMAN	Macular degeneration, age-related, 2 (ARMD2) [MIM 153800]  A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. {ECO 0000269|PubMed 19028736, ECO 0000269|PubMed 9295268}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# DISEASE	ABCA4_HUMAN	Retinitis pigmentosa 19 (RP19) [MIM 601718]  A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP19 is characterized by choroidal atrophy. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ABCA4_HUMAN	Stargardt disease 1 (STGD1) [MIM 248200]  A common hereditary macular degeneration. It is characterized by decreased central vision, atrophy of the macula and underlying retinal pigment epithelium, and frequent presence of prominent flecks in the posterior pole of the retina. {ECO 0000269|PubMed 10090887, ECO 0000269|PubMed 10206579, ECO 0000269|PubMed 10612508, ECO 0000269|PubMed 10634594, ECO 0000269|PubMed 10711710, ECO 0000269|PubMed 10746567, ECO 0000269|PubMed 10958763, ECO 0000269|PubMed 11328725, ECO 0000269|PubMed 11385708, ECO 0000269|PubMed 11527935, ECO 0000269|PubMed 11594993, ECO 0000269|PubMed 18977788, ECO 0000269|PubMed 24444108, ECO 0000269|PubMed 9054934, ECO 0000269|PubMed 9490294, ECO 0000269|PubMed 9503029, ECO 0000269|PubMed 9781034, ECO 0000269|PubMed 9973280}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000370225	ENSP00000359245; ENSG00000198691
# ExpressionAtlas	P78363	baseline and differential
# FUNCTION	ABCA4_HUMAN	In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans- retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery. {ECO 0000269|PubMed 10075733}. 
# GO_component	GO:0005887	integral component of plasma membrane; IEA:InterPro.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IBA:GO_Central.
# GO_component	GO:0097381	photoreceptor disc membrane; TAS:Reactome.
# GO_function	GO:0005215	transporter activity; TAS:ProtInc.
# GO_function	GO:0005395	eye pigment precursor transporter activity; TAS:Reactome.
# GO_function	GO:0005524	ATP binding; TAS:ProtInc.
# GO_function	GO:0016887	ATPase activity; IDA:BHF-UCL.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; TAS:ProtInc.
# GO_function	GO:0090555	phosphatidylethanolamine-translocating ATPase activity; IDA:BHF-UCL.
# GO_process	GO:0001523	retinoid metabolic process; TAS:Reactome.
# GO_process	GO:0006649	phospholipid transfer to membrane; IEA:Ensembl.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006869	lipid transport; IBA:GO_Central.
# GO_process	GO:0007601	visual perception; TAS:ProtInc.
# GO_process	GO:0007603	phototransduction, visible light; TAS:ProtInc.
# GO_process	GO:0045332	phospholipid translocation; IDA:BHF-UCL.
# GO_process	GO:0045494	photoreceptor cell maintenance; IEA:Ensembl.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# GOslim_process	GO:0061024	membrane organization
# Gene3D	3.40.50.300	-; 2.
# Genevisible	P78363	HS
# HGNC	HGNC:34	ABCA4
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR005951	ABCA4/ABCR
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR026082	ABC_A
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Disease	H00481	[Inherited metabolic disease; Nervous system disease; Eye disease] Retinal cone dystrophy (RCD)
# KEGG_Disease	H00527	[Inherited metabolic disease; Nervous system disease; Eye disease] Retinitis pigmentosa (RP)
# KEGG_Disease	H00819	[Nervous system disease; Eye disease] Fundus flavimaculatus
# KEGG_Disease	H00821	[Nervous system disease; Eye disease] X-linked atrophic macular degeneration (MDXLA)
# KEGG_Pathway	ko02010	ABC transporters
# MIM	153800	phenotype
# MIM	248200	phenotype
# MIM	601691	gene
# MIM	601718	phenotype
# MIM	604116	phenotype
# Organism	ABCA4_HUMAN	Homo sapiens (Human)
# Orphanet	1872	Cone rod dystrophy
# Orphanet	279	Age-related macular degeneration
# Orphanet	791	Retinitis pigmentosa
# Orphanet	827	Stargardt disease
# PANTHER	PTHR19229	PTHR19229; 6
# PANTHER	PTHR19229:SF97	PTHR19229:SF97; 6
# PROSITE	PS00211	ABC_TRANSPORTER_1
# PROSITE	PS50893	ABC_TRANSPORTER_2; 2
# Pfam	PF00005	ABC_tran; 2
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-2453902	The canonical retinoid cycle in rods (twilight vision)
# Reactome	R-HSA-382556	ABC-family proteins mediated transport
# RecName	ABCA4_HUMAN	Retinal-specific ATP-binding cassette transporter
# RefSeq	NP_000341	NM_000350.2
# SEQUENCE CAUTION	Sequence=BAE06122.1; Type=Erroneous initiation; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCA family. {ECO	0000305}. 
# SIMILARITY	Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA; 2
# SUBCELLULAR LOCATION	ABCA4_HUMAN	Membrane {ECO 0000269|PubMed 10075733}; Multi-pass membrane protein {ECO 0000269|PubMed 10075733}. Note=Localized to outer segment disk edges of rods and cones, with around one million copies/photoreceptor. 
# SUPFAM	SSF52540	SSF52540; 2
# TCDB	3.A.1.211	the atp-binding cassette (abc) superfamily
# TIGRFAMs	TIGR01257	rim_protein
# TISSUE SPECIFICITY	ABCA4_HUMAN	Retinal-specific. Seems to be exclusively found in the rims of rod photoreceptor cells. 
# UCSC	uc001dqh	human
# WEB RESOURCE	ABCA4_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=P78363";
# WEB RESOURCE	ABCA4_HUMAN	Name=Mutations of the ABCA4 gene; Note=Retina International's Scientific Newsletter; URL="http //www.retina-international.org/files/sci-news/abcrmut.htm"; 
# eggNOG	COG1131	LUCA
# eggNOG	KOG0059	Eukaryota
BLAST	swissprot:ABCA4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCA4_HUMAN
BioCyc	ZFISH:G66-31851-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31851-MONOMER
COXPRESdb	24	http://coxpresdb.jp/data/gene/24.shtml
CleanEx	HS_ABCA4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCA4
DOI	10.1001/archopht.117.4.504	http://dx.doi.org/10.1001/archopht.117.4.504
DOI	10.1001/archopht.119.5.745	http://dx.doi.org/10.1001/archopht.119.5.745
DOI	10.1002/humu.1133	http://dx.doi.org/10.1002/humu.1133
DOI	10.1006/geno.1997.5164	http://dx.doi.org/10.1006/geno.1997.5164
DOI	10.1007/s004390050649	http://dx.doi.org/10.1007/s004390050649
DOI	10.1007/s004390051034	http://dx.doi.org/10.1007/s004390051034
DOI	10.1007/s004390100493	http://dx.doi.org/10.1007/s004390100493
DOI	10.1007/s100380200041	http://dx.doi.org/10.1007/s100380200041
DOI	10.1016/S0002-9394(01)00838-8	http://dx.doi.org/10.1016/S0002-9394(01)00838-8
DOI	10.1016/S0002-9394(99)00236-6	http://dx.doi.org/10.1016/S0002-9394(99)00236-6
DOI	10.1016/S0014-5793(97)00517-6	http://dx.doi.org/10.1016/S0014-5793(97)00517-6
DOI	10.1034/j.1600-0420.2001.790520.x	http://dx.doi.org/10.1034/j.1600-0420.2001.790520.x
DOI	10.1038/79994	http://dx.doi.org/10.1038/79994
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng0397-236	http://dx.doi.org/10.1038/ng0397-236
DOI	10.1038/sj.ejhg.5200221	http://dx.doi.org/10.1038/sj.ejhg.5200221
DOI	10.1074/jbc.274.12.8269	http://dx.doi.org/10.1074/jbc.274.12.8269
DOI	10.1074/jbc.M101902200	http://dx.doi.org/10.1074/jbc.M101902200
DOI	10.1086/302251	http://dx.doi.org/10.1086/302251
DOI	10.1086/302323	http://dx.doi.org/10.1086/302323
DOI	10.1086/303018	http://dx.doi.org/10.1086/303018
DOI	10.1086/303079	http://dx.doi.org/10.1086/303079
DOI	10.1086/303090	http://dx.doi.org/10.1086/303090
DOI	10.1093/hmg/7.3.355	http://dx.doi.org/10.1093/hmg/7.3.355
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1126/science.277.5333.1805	http://dx.doi.org/10.1126/science.277.5333.1805
DOI	10.1136/bjo.2008.145193	http://dx.doi.org/10.1136/bjo.2008.145193
DOI	10.1136/bjo.2008.148155	http://dx.doi.org/10.1136/bjo.2008.148155
DOI	10.1186/1471-2164-8-42	http://dx.doi.org/10.1186/1471-2164-8-42
DOI	10.1186/1471-2350-15-11	http://dx.doi.org/10.1186/1471-2350-15-11
EMBL	AB210040	http://www.ebi.ac.uk/ena/data/view/AB210040
EMBL	AC093579	http://www.ebi.ac.uk/ena/data/view/AC093579
EMBL	AC105278	http://www.ebi.ac.uk/ena/data/view/AC105278
EMBL	AF000148	http://www.ebi.ac.uk/ena/data/view/AF000148
EMBL	AF001945	http://www.ebi.ac.uk/ena/data/view/AF001945
EMBL	DQ426859	http://www.ebi.ac.uk/ena/data/view/DQ426859
EMBL	U88667	http://www.ebi.ac.uk/ena/data/view/U88667
EMBL	Y15635	http://www.ebi.ac.uk/ena/data/view/Y15635
EMBL	Y15636	http://www.ebi.ac.uk/ena/data/view/Y15636
EMBL	Y15637	http://www.ebi.ac.uk/ena/data/view/Y15637
EMBL	Y15638	http://www.ebi.ac.uk/ena/data/view/Y15638
EMBL	Y15639	http://www.ebi.ac.uk/ena/data/view/Y15639
EMBL	Y15640	http://www.ebi.ac.uk/ena/data/view/Y15640
EMBL	Y15641	http://www.ebi.ac.uk/ena/data/view/Y15641
EMBL	Y15642	http://www.ebi.ac.uk/ena/data/view/Y15642
EMBL	Y15643	http://www.ebi.ac.uk/ena/data/view/Y15643
EMBL	Y15644	http://www.ebi.ac.uk/ena/data/view/Y15644
EMBL	Y15645	http://www.ebi.ac.uk/ena/data/view/Y15645
EMBL	Y15646	http://www.ebi.ac.uk/ena/data/view/Y15646
EMBL	Y15647	http://www.ebi.ac.uk/ena/data/view/Y15647
EMBL	Y15648	http://www.ebi.ac.uk/ena/data/view/Y15648
EMBL	Y15649	http://www.ebi.ac.uk/ena/data/view/Y15649
EMBL	Y15650	http://www.ebi.ac.uk/ena/data/view/Y15650
EMBL	Y15651	http://www.ebi.ac.uk/ena/data/view/Y15651
EMBL	Y15652	http://www.ebi.ac.uk/ena/data/view/Y15652
EMBL	Y15653	http://www.ebi.ac.uk/ena/data/view/Y15653
EMBL	Y15654	http://www.ebi.ac.uk/ena/data/view/Y15654
EMBL	Y15655	http://www.ebi.ac.uk/ena/data/view/Y15655
EMBL	Y15656	http://www.ebi.ac.uk/ena/data/view/Y15656
EMBL	Y15657	http://www.ebi.ac.uk/ena/data/view/Y15657
EMBL	Y15658	http://www.ebi.ac.uk/ena/data/view/Y15658
EMBL	Y15659	http://www.ebi.ac.uk/ena/data/view/Y15659
EMBL	Y15660	http://www.ebi.ac.uk/ena/data/view/Y15660
EMBL	Y15661	http://www.ebi.ac.uk/ena/data/view/Y15661
EMBL	Y15662	http://www.ebi.ac.uk/ena/data/view/Y15662
EMBL	Y15663	http://www.ebi.ac.uk/ena/data/view/Y15663
EMBL	Y15664	http://www.ebi.ac.uk/ena/data/view/Y15664
EMBL	Y15665	http://www.ebi.ac.uk/ena/data/view/Y15665
EMBL	Y15666	http://www.ebi.ac.uk/ena/data/view/Y15666
EMBL	Y15667	http://www.ebi.ac.uk/ena/data/view/Y15667
EMBL	Y15668	http://www.ebi.ac.uk/ena/data/view/Y15668
EMBL	Y15669	http://www.ebi.ac.uk/ena/data/view/Y15669
EMBL	Y15670	http://www.ebi.ac.uk/ena/data/view/Y15670
EMBL	Y15671	http://www.ebi.ac.uk/ena/data/view/Y15671
EMBL	Y15672	http://www.ebi.ac.uk/ena/data/view/Y15672
EMBL	Y15673	http://www.ebi.ac.uk/ena/data/view/Y15673
EMBL	Y15674	http://www.ebi.ac.uk/ena/data/view/Y15674
EMBL	Y15675	http://www.ebi.ac.uk/ena/data/view/Y15675
EMBL	Y15676	http://www.ebi.ac.uk/ena/data/view/Y15676
EMBL	Y15677	http://www.ebi.ac.uk/ena/data/view/Y15677
EMBL	Y15678	http://www.ebi.ac.uk/ena/data/view/Y15678
EMBL	Y15679	http://www.ebi.ac.uk/ena/data/view/Y15679
EMBL	Y15680	http://www.ebi.ac.uk/ena/data/view/Y15680
EMBL	Y15681	http://www.ebi.ac.uk/ena/data/view/Y15681
EMBL	Y15682	http://www.ebi.ac.uk/ena/data/view/Y15682
EMBL	Y15683	http://www.ebi.ac.uk/ena/data/view/Y15683
EMBL	Y15684	http://www.ebi.ac.uk/ena/data/view/Y15684
Ensembl	ENST00000370225	http://www.ensembl.org/id/ENST00000370225
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_component	GO:0097381	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097381
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0005395	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005395
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GO_function	GO:0090555	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090555
GO_process	GO:0001523	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001523
GO_process	GO:0006649	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006649
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006869	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006869
GO_process	GO:0007601	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007601
GO_process	GO:0007603	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007603
GO_process	GO:0045332	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045332
GO_process	GO:0045494	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045494
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCA4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCA4
GeneID	24	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24
GeneTree	ENSGT00760000118965	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118965
H-InvDB	HIX0028510	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0028510
HGNC	HGNC:34	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:34
HOGENOM	HOG000231547	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231547&db=HOGENOM6
HOVERGEN	HBG050436	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050436&db=HOVERGEN
InParanoid	P78363	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P78363
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR005951	http://www.ebi.ac.uk/interpro/entry/IPR005951
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR026082	http://www.ebi.ac.uk/interpro/entry/IPR026082
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	24	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=24
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Disease	H00481	http://www.genome.jp/dbget-bin/www_bget?H00481
KEGG_Disease	H00527	http://www.genome.jp/dbget-bin/www_bget?H00527
KEGG_Disease	H00819	http://www.genome.jp/dbget-bin/www_bget?H00819
KEGG_Disease	H00821	http://www.genome.jp/dbget-bin/www_bget?H00821
KEGG_Gene	hsa:24	http://www.genome.jp/dbget-bin/www_bget?hsa:24
KEGG_Orthology	KO:K05644	http://www.genome.jp/dbget-bin/www_bget?KO:K05644
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
MIM	153800	http://www.ncbi.nlm.nih.gov/omim/153800
MIM	248200	http://www.ncbi.nlm.nih.gov/omim/248200
MIM	601691	http://www.ncbi.nlm.nih.gov/omim/601691
MIM	601718	http://www.ncbi.nlm.nih.gov/omim/601718
MIM	604116	http://www.ncbi.nlm.nih.gov/omim/604116
OMA	RHPCLGP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RHPCLGP
Orphanet	1872	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1872
Orphanet	279	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=279
Orphanet	791	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=791
Orphanet	827	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=827
OrthoDB	EOG091G007E	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G007E
PANTHER	PTHR19229	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19229
PANTHER	PTHR19229:SF97	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19229:SF97
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PSORT	swissprot:ABCA4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCA4_HUMAN
PSORT-B	swissprot:ABCA4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCA4_HUMAN
PSORT2	swissprot:ABCA4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCA4_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
PharmGKB	PA24379	http://www.pharmgkb.org/do/serve?objId=PA24379&objCls=Gene
Phobius	swissprot:ABCA4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCA4_HUMAN
PhylomeDB	P78363	http://phylomedb.org/?seqid=P78363
ProteinModelPortal	P78363	http://www.proteinmodelportal.org/query/uniprot/P78363
PubMed	10075733	http://www.ncbi.nlm.nih.gov/pubmed/10075733
PubMed	10090887	http://www.ncbi.nlm.nih.gov/pubmed/10090887
PubMed	10206579	http://www.ncbi.nlm.nih.gov/pubmed/10206579
PubMed	10612508	http://www.ncbi.nlm.nih.gov/pubmed/10612508
PubMed	10634594	http://www.ncbi.nlm.nih.gov/pubmed/10634594
PubMed	10711710	http://www.ncbi.nlm.nih.gov/pubmed/10711710
PubMed	10746567	http://www.ncbi.nlm.nih.gov/pubmed/10746567
PubMed	10880298	http://www.ncbi.nlm.nih.gov/pubmed/10880298
PubMed	10958761	http://www.ncbi.nlm.nih.gov/pubmed/10958761
PubMed	10958763	http://www.ncbi.nlm.nih.gov/pubmed/10958763
PubMed	11017087	http://www.ncbi.nlm.nih.gov/pubmed/11017087
PubMed	11320094	http://www.ncbi.nlm.nih.gov/pubmed/11320094
PubMed	11328725	http://www.ncbi.nlm.nih.gov/pubmed/11328725
PubMed	11346402	http://www.ncbi.nlm.nih.gov/pubmed/11346402
PubMed	11379881	http://www.ncbi.nlm.nih.gov/pubmed/11379881
PubMed	11384574	http://www.ncbi.nlm.nih.gov/pubmed/11384574
PubMed	11385708	http://www.ncbi.nlm.nih.gov/pubmed/11385708
PubMed	11527935	http://www.ncbi.nlm.nih.gov/pubmed/11527935
PubMed	11594993	http://www.ncbi.nlm.nih.gov/pubmed/11594993
PubMed	12111378	http://www.ncbi.nlm.nih.gov/pubmed/12111378
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	17286855	http://www.ncbi.nlm.nih.gov/pubmed/17286855
PubMed	18977788	http://www.ncbi.nlm.nih.gov/pubmed/18977788
PubMed	19028736	http://www.ncbi.nlm.nih.gov/pubmed/19028736
PubMed	24444108	http://www.ncbi.nlm.nih.gov/pubmed/24444108
PubMed	9054934	http://www.ncbi.nlm.nih.gov/pubmed/9054934
PubMed	9202155	http://www.ncbi.nlm.nih.gov/pubmed/9202155
PubMed	9295268	http://www.ncbi.nlm.nih.gov/pubmed/9295268
PubMed	9466990	http://www.ncbi.nlm.nih.gov/pubmed/9466990
PubMed	9490294	http://www.ncbi.nlm.nih.gov/pubmed/9490294
PubMed	9503029	http://www.ncbi.nlm.nih.gov/pubmed/9503029
PubMed	9781034	http://www.ncbi.nlm.nih.gov/pubmed/9781034
PubMed	9973280	http://www.ncbi.nlm.nih.gov/pubmed/9973280
Reactome	R-HSA-2453902	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2453902
Reactome	R-HSA-382556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-382556
RefSeq	NP_000341	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000341
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	P78363	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P78363
STRING	9606.ENSP00000359245	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000359245&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TCDB	3.A.1.211	http://www.tcdb.org/search/result.php?tc=3.A.1.211
TIGRFAMs	TIGR01257	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01257
UCSC	uc001dqh	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001dqh&org=rat
UniGene	Hs.416707	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.416707
UniProtKB	ABCA4_HUMAN	http://www.uniprot.org/uniprot/ABCA4_HUMAN
UniProtKB-AC	P78363	http://www.uniprot.org/uniprot/P78363
charge	swissprot:ABCA4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCA4_HUMAN
eggNOG	COG1131	http://eggnogapi.embl.de/nog_data/html/tree/COG1131
eggNOG	KOG0059	http://eggnogapi.embl.de/nog_data/html/tree/KOG0059
epestfind	swissprot:ABCA4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCA4_HUMAN
garnier	swissprot:ABCA4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCA4_HUMAN
helixturnhelix	swissprot:ABCA4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCA4_HUMAN
hmoment	swissprot:ABCA4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCA4_HUMAN
iep	swissprot:ABCA4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCA4_HUMAN
inforesidue	swissprot:ABCA4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCA4_HUMAN
neXtProt	NX_P78363	http://www.nextprot.org/db/entry/NX_P78363
octanol	swissprot:ABCA4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCA4_HUMAN
pepcoil	swissprot:ABCA4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCA4_HUMAN
pepdigest	swissprot:ABCA4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCA4_HUMAN
pepinfo	swissprot:ABCA4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCA4_HUMAN
pepnet	swissprot:ABCA4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCA4_HUMAN
pepstats	swissprot:ABCA4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCA4_HUMAN
pepwheel	swissprot:ABCA4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCA4_HUMAN
pepwindow	swissprot:ABCA4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCA4_HUMAN
sigcleave	swissprot:ABCA4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCA4_HUMAN
## Database	ID	URL or Descriptions
# AltName	ATP4A_HUMAN	Gastric H(+)/K(+) ATPase subunit alpha
# AltName	ATP4A_HUMAN	Proton pump
# BRENDA	3.6.3.10	2681
# BioGrid	106985	89
# CATALYTIC ACTIVITY	ATP4A_HUMAN	ATP + H(2)O + H(+)(In) + K(+)(Out) = ADP + phosphate + H(+)(Out) + K(+)(In). 
# DrugBank	DB00213	Pantoprazole
# DrugBank	DB00338	Omeprazole
# DrugBank	DB00448	Lansoprazole
# DrugBank	DB00736	Esomeprazole
# DrugBank	DB01129	Rabeprazole
# Ensembl	ENST00000262623	ENSP00000262623; ENSG00000105675
# ExpressionAtlas	P20648	baseline and differential
# FUNCTION	ATP4A_HUMAN	Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach. 
# GO_component	GO:0005615	extracellular space; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IBA:GO_Central.
# GO_function	ATP4A_HUMAN	GO 0005391 sodium potassium-exchanging ATPase activity; IBA GO_Central.
# GO_function	ATP4A_HUMAN	GO 0008900 hydrogen potassium-exchanging ATPase activity; TAS ProtInc.
# GO_function	GO:0000287	magnesium ion binding; IEA:InterPro.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006883	cellular sodium ion homeostasis; IBA:GO_Central.
# GO_process	GO:0010107	potassium ion import; IBA:GO_Central.
# GO_process	GO:0015991	ATP hydrolysis coupled proton transport; IBA:GO_Central.
# GO_process	GO:0030007	cellular potassium ion homeostasis; IBA:GO_Central.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0036376	sodium ion export from cell; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005615	extracellular space
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.1110.10	-; 2.
# Gene3D	2.70.150.10	-; 2.
# Gene3D	3.40.1110.10	-; 1.
# Genevisible	P20648	HS
# HGNC	HGNC:819	ATP4A
# InterPro	IPR001757	P_typ_ATPase
# InterPro	IPR004014	ATPase_P-typ_cation-transptr_N
# InterPro	IPR005775	P-type_ATPase_IIC
# InterPro	IPR006068	ATPase_P-typ_cation-transptr_C
# InterPro	IPR008250	ATPase_P-typ_transduc_dom_A
# InterPro	IPR015127	ATPase_P-typ_H/K-transp_N
# InterPro	IPR018303	ATPase_P-typ_P_site
# InterPro	IPR023214	HAD-like_dom
# InterPro	IPR023298	ATPase_P-typ_TM_dom
# InterPro	IPR023299	ATPase_P-typ_cyto_domN
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04966	Collecting duct acid secretion
# KEGG_Pathway	ko04971	Gastric acid secretion
# MIM	137216	gene
# Organism	ATP4A_HUMAN	Homo sapiens (Human)
# PIR	A36558	A35292
# PIR	C27397	C27397
# PROSITE	PS00154	ATPASE_E1_E2
# Pfam	PF00122	E1-E2_ATPase
# Pfam	PF00689	Cation_ATPase_C
# Pfam	PF00690	Cation_ATPase_N
# Pfam	PF09040	H-K_ATPase_N
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	ATP4A_HUMAN	Potassium-transporting ATPase alpha chain 1
# RefSeq	NP_000695	NM_000704.2
# SIMILARITY	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. {ECO	0000305}.
# SMART	SM00831	Cation_ATPase_N
# SUBCELLULAR LOCATION	ATP4A_HUMAN	Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Composed of two subunits	 alpha (catalytic) and beta. 
# SUPFAM	SSF56784	SSF56784; 3
# SUPFAM	SSF81660	SSF81660
# TCDB	3.A.3.1	the p-type atpase (p-atpase) superfamily
# TIGRFAMs	TIGR01106	ATPase-IIC_X-K
# TIGRFAMs	TIGR01494	ATPase_P-type; 2
# TISSUE SPECIFICITY	ATP4A_HUMAN	Found in gastric mucosa. 
# UCSC	uc002oal	human
# eggNOG	COG0474	LUCA
# eggNOG	KOG0203	Eukaryota
BLAST	swissprot:ATP4A_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ATP4A_HUMAN
BioCyc	MetaCyc:HS02790-MONOMER	http://biocyc.org/getid?id=MetaCyc:HS02790-MONOMER
BioCyc	ZFISH:HS02790-MONOMER	http://biocyc.org/getid?id=ZFISH:HS02790-MONOMER
COXPRESdb	495	http://coxpresdb.jp/data/gene/495.shtml
CleanEx	HS_ATP4A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP4A
DOI	10.1016/0014-5793(87)80677-4	http://dx.doi.org/10.1016/0014-5793(87)80677-4
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DOI	10.1089/dna.1990.9.749	http://dx.doi.org/10.1089/dna.1990.9.749
DrugBank	DB00213	http://www.drugbank.ca/drugs/DB00213
DrugBank	DB00338	http://www.drugbank.ca/drugs/DB00338
DrugBank	DB00448	http://www.drugbank.ca/drugs/DB00448
DrugBank	DB00736	http://www.drugbank.ca/drugs/DB00736
DrugBank	DB01129	http://www.drugbank.ca/drugs/DB01129
EC_number	EC:3.6.3.10	http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.10
EMBL	AC002389	http://www.ebi.ac.uk/ena/data/view/AC002389
EMBL	AD000090	http://www.ebi.ac.uk/ena/data/view/AD000090
EMBL	J05451	http://www.ebi.ac.uk/ena/data/view/J05451
EMBL	M27575	http://www.ebi.ac.uk/ena/data/view/M27575
EMBL	M63962	http://www.ebi.ac.uk/ena/data/view/M63962
ENZYME	3.6.3.10	http://enzyme.expasy.org/EC/3.6.3.10
Ensembl	ENST00000262623	http://www.ensembl.org/id/ENST00000262623
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005615
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0000287	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287
GO_function	GO:0005391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005391
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0008900	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008900
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006883	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006883
GO_process	GO:0010107	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010107
GO_process	GO:0015991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015991
GO_process	GO:0030007	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030007
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0036376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036376
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005615
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.1110.10	http://www.cathdb.info/version/latest/superfamily/1.20.1110.10
Gene3D	2.70.150.10	http://www.cathdb.info/version/latest/superfamily/2.70.150.10
Gene3D	3.40.1110.10	http://www.cathdb.info/version/latest/superfamily/3.40.1110.10
GeneCards	ATP4A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP4A
GeneID	495	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=495
GeneTree	ENSGT00850000132256	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00850000132256
HGNC	HGNC:819	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:819
HOGENOM	HOG000265622	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265622&db=HOGENOM6
HOVERGEN	HBG004298	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004298&db=HOVERGEN
HPA	HPA039154	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA039154
InParanoid	P20648	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P20648
IntEnz	3.6.3.10	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.10
InterPro	IPR001757	http://www.ebi.ac.uk/interpro/entry/IPR001757
InterPro	IPR004014	http://www.ebi.ac.uk/interpro/entry/IPR004014
InterPro	IPR005775	http://www.ebi.ac.uk/interpro/entry/IPR005775
InterPro	IPR006068	http://www.ebi.ac.uk/interpro/entry/IPR006068
InterPro	IPR008250	http://www.ebi.ac.uk/interpro/entry/IPR008250
InterPro	IPR015127	http://www.ebi.ac.uk/interpro/entry/IPR015127
InterPro	IPR018303	http://www.ebi.ac.uk/interpro/entry/IPR018303
InterPro	IPR023214	http://www.ebi.ac.uk/interpro/entry/IPR023214
InterPro	IPR023298	http://www.ebi.ac.uk/interpro/entry/IPR023298
InterPro	IPR023299	http://www.ebi.ac.uk/interpro/entry/IPR023299
Jabion	495	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=495
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:495	http://www.genome.jp/dbget-bin/www_bget?hsa:495
KEGG_Orthology	KO:K01542	http://www.genome.jp/dbget-bin/www_bget?KO:K01542
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04966	http://www.genome.jp/kegg-bin/show_pathway?ko04966
KEGG_Pathway	ko04971	http://www.genome.jp/kegg-bin/show_pathway?ko04971
MIM	137216	http://www.ncbi.nlm.nih.gov/omim/137216
OMA	EDMNFPS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EDMNFPS
OrthoDB	EOG091G01BB	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01BB
PROSITE	PS00154	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00154
PSORT	swissprot:ATP4A_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ATP4A_HUMAN
PSORT-B	swissprot:ATP4A_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ATP4A_HUMAN
PSORT2	swissprot:ATP4A_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ATP4A_HUMAN
Pfam	PF00122	http://pfam.xfam.org/family/PF00122
Pfam	PF00689	http://pfam.xfam.org/family/PF00689
Pfam	PF00690	http://pfam.xfam.org/family/PF00690
Pfam	PF09040	http://pfam.xfam.org/family/PF09040
PharmGKB	PA25113	http://www.pharmgkb.org/do/serve?objId=PA25113&objCls=Gene
Phobius	swissprot:ATP4A_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ATP4A_HUMAN
PhylomeDB	P20648	http://phylomedb.org/?seqid=P20648
ProteinModelPortal	P20648	http://www.proteinmodelportal.org/query/uniprot/P20648
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	2160952	http://www.ncbi.nlm.nih.gov/pubmed/2160952
PubMed	2176086	http://www.ncbi.nlm.nih.gov/pubmed/2176086
PubMed	3036582	http://www.ncbi.nlm.nih.gov/pubmed/3036582
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_000695	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000695
SMART	SM00831	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00831
SMR	P20648	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P20648
STRING	9606.ENSP00000262623	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000262623&targetmode=cogs
SUPFAM	SSF56784	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784
SUPFAM	SSF81660	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81660
TCDB	3.A.3.1	http://www.tcdb.org/search/result.php?tc=3.A.3.1
TIGRFAMs	TIGR01106	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01106
TIGRFAMs	TIGR01494	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01494
UCSC	uc002oal	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002oal&org=rat
UniGene	Hs.36992	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.36992
UniProtKB	ATP4A_HUMAN	http://www.uniprot.org/uniprot/ATP4A_HUMAN
UniProtKB-AC	P20648	http://www.uniprot.org/uniprot/P20648
charge	swissprot:ATP4A_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ATP4A_HUMAN
eggNOG	COG0474	http://eggnogapi.embl.de/nog_data/html/tree/COG0474
eggNOG	KOG0203	http://eggnogapi.embl.de/nog_data/html/tree/KOG0203
epestfind	swissprot:ATP4A_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ATP4A_HUMAN
garnier	swissprot:ATP4A_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ATP4A_HUMAN
helixturnhelix	swissprot:ATP4A_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATP4A_HUMAN
hmoment	swissprot:ATP4A_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ATP4A_HUMAN
iep	swissprot:ATP4A_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ATP4A_HUMAN
inforesidue	swissprot:ATP4A_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ATP4A_HUMAN
neXtProt	NX_P20648	http://www.nextprot.org/db/entry/NX_P20648
octanol	swissprot:ATP4A_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ATP4A_HUMAN
pepcoil	swissprot:ATP4A_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ATP4A_HUMAN
pepdigest	swissprot:ATP4A_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ATP4A_HUMAN
pepinfo	swissprot:ATP4A_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ATP4A_HUMAN
pepnet	swissprot:ATP4A_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ATP4A_HUMAN
pepstats	swissprot:ATP4A_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ATP4A_HUMAN
pepwheel	swissprot:ATP4A_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ATP4A_HUMAN
pepwindow	swissprot:ATP4A_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ATP4A_HUMAN
sigcleave	swissprot:ATP4A_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ATP4A_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNC4_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q03721-1; Sequence=Displayed; Name=2; IsoId=Q03721-2; Sequence=VSP_020581, VSP_020582; Note=Could be a cloning artifact.; Name=3; IsoId=Q03721-3; Sequence=VSP_040033; Note=Gene prediction based on EST data.; 
# AltName	KCNC4_HUMAN	KSHIIIC
# AltName	KCNC4_HUMAN	Voltage-gated potassium channel subunit Kv3.4
# BioGrid	109951	27
# CCDS	CCDS44193	-. [Q03721-3]
# CCDS	CCDS821	-. [Q03721-1]
# DOMAIN	KCNC4_HUMAN	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. 
# DOMAIN	KCNC4_HUMAN	The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. 
# Ensembl	ENST00000369787	ENSP00000358802; ENSG00000116396. [Q03721-1]
# Ensembl	ENST00000438661	ENSP00000393655; ENSG00000116396. [Q03721-3]
# Ensembl	ENST00000469655	ENSP00000436656; ENSG00000116396. [Q03721-1]
# ExpressionAtlas	Q03721	baseline and differential
# FUNCTION	KCNC4_HUMAN	This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008076	voltage-gated potassium channel complex; TAS:ProtInc.
# GO_component	GO:0031594	neuromuscular junction; IEA:Ensembl.
# GO_component	GO:0043679	axon terminus; IEA:Ensembl.
# GO_function	GO:0005249	voltage-gated potassium channel activity; TAS:ProtInc.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; IBA:GO_Central.
# GO_function	GO:0005267	potassium channel activity; TAS:ProtInc.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:ProtInc.
# GO_process	GO:0046928	regulation of neurotransmitter secretion; IEA:Ensembl.
# GO_process	GO:0051260	protein homooligomerization; IEA:InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.20.120.350	-; 1.
# Genevisible	Q03721	HS
# HGNC	HGNC:6236	KCNC4
# InterPro	IPR000210	BTB/POZ_dom
# InterPro	IPR003131	T1-type_BTB
# InterPro	IPR003968	K_chnl_volt-dep_Kv
# InterPro	IPR003974	K_chnl_volt-dep_Kv3
# InterPro	IPR005405	K_chnl_volt-dep_Kv3.4
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR011333	SKP1/BTB/POZ
# InterPro	IPR021105	K_chnl_volt-dep_Kv3_ID
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko04040	Ion channels
# MIM	176265	gene
# Organism	KCNC4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11537	PTHR11537; 3
# PDB	1B4G	NMR; -; A=1-30
# PDB	1B4I	NMR; -; A=1-30
# PDB	1ZTN	NMR; -; A=1-30
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01491	KVCHANNEL
# PRINTS	PR01498	SHAWCHANNEL
# PRINTS	PR01583	KV34CHANNEL
# PTM	KCNC4_HUMAN	Phosphorylation of serine residues in the inactivation gate inhibits rapid channel closure. {ECO 0000269|PubMed 7993631, ECO 0000269|PubMed 9649584}. 
# Pfam	PF00520	Ion_trans
# Pfam	PF02214	BTB_2
# Pfam	PF11404	Potassium_chann
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# RecName	KCNC4_HUMAN	Potassium voltage-gated channel subfamily C member 4
# RefSeq	NP_001034663	NM_001039574.2. [Q03721-3]
# RefSeq	NP_004969	NM_004978.4. [Q03721-1]
# SIMILARITY	Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.4/KCNC4 sub-subfamily. {ECO	0000305}.
# SMART	SM00225	BTB
# SUBCELLULAR LOCATION	KCNC4_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Homotetramer (Probable). Heterotetramer of potassium channel proteins (By similarity). {ECO:0000250, ECO	0000305}. 
# SUPFAM	SSF54695	SSF54695
# TopDownProteomics	Q03721-3	-. [Q03721-3]
# UCSC	uc001dzg	human. [Q03721-1]
# eggNOG	COG1226	LUCA
# eggNOG	KOG3713	Eukaryota
BLAST	swissprot:KCNC4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNC4_HUMAN
BioCyc	ZFISH:ENSG00000116396-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000116396-MONOMER
COXPRESdb	3749	http://coxpresdb.jp/data/gene/3749.shtml
CleanEx	HS_KCNC4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNC4
DOI	10.1016/0896-6273(94)90425-1	http://dx.doi.org/10.1016/0896-6273(94)90425-1
DOI	10.1038/385272a0	http://dx.doi.org/10.1038/385272a0
DOI	10.1038/5833	http://dx.doi.org/10.1038/5833
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1085/jgp.112.1.71	http://dx.doi.org/10.1085/jgp.112.1.71
DOI	10.1098/rspb.1992.0036	http://dx.doi.org/10.1098/rspb.1992.0036
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AL137790	http://www.ebi.ac.uk/ena/data/view/AL137790
EMBL	BC019010	http://www.ebi.ac.uk/ena/data/view/BC019010
EMBL	BC101769	http://www.ebi.ac.uk/ena/data/view/BC101769
EMBL	M64676	http://www.ebi.ac.uk/ena/data/view/M64676
Ensembl	ENST00000369787	http://www.ensembl.org/id/ENST00000369787
Ensembl	ENST00000438661	http://www.ensembl.org/id/ENST00000438661
Ensembl	ENST00000469655	http://www.ensembl.org/id/ENST00000469655
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0031594	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031594
GO_component	GO:0043679	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043679
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0046928	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046928
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	KCNC4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNC4
GeneID	3749	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3749
GeneTree	ENSGT00760000118846	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118846
H-InvDB	HIX0023584	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0023584
HGNC	HGNC:6236	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6236
HOGENOM	HOG000231012	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231012&db=HOGENOM6
HOVERGEN	HBG105862	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG105862&db=HOVERGEN
HPA	HPA014740	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014740
InParanoid	Q03721	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q03721
IntAct	Q03721	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q03721*
InterPro	IPR000210	http://www.ebi.ac.uk/interpro/entry/IPR000210
InterPro	IPR003131	http://www.ebi.ac.uk/interpro/entry/IPR003131
InterPro	IPR003968	http://www.ebi.ac.uk/interpro/entry/IPR003968
InterPro	IPR003974	http://www.ebi.ac.uk/interpro/entry/IPR003974
InterPro	IPR005405	http://www.ebi.ac.uk/interpro/entry/IPR005405
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR011333	http://www.ebi.ac.uk/interpro/entry/IPR011333
InterPro	IPR021105	http://www.ebi.ac.uk/interpro/entry/IPR021105
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	3749	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3749
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3749	http://www.genome.jp/dbget-bin/www_bget?hsa:3749
KEGG_Orthology	KO:K04890	http://www.genome.jp/dbget-bin/www_bget?KO:K04890
MIM	176265	http://www.ncbi.nlm.nih.gov/omim/176265
OMA	GCEFFFD	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GCEFFFD
OrthoDB	EOG091G0EJL	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0EJL
PANTHER	PTHR11537	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537
PDB	1B4G	http://www.ebi.ac.uk/pdbe-srv/view/entry/1B4G
PDB	1B4I	http://www.ebi.ac.uk/pdbe-srv/view/entry/1B4I
PDB	1ZTN	http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZTN
PDBsum	1B4G	http://www.ebi.ac.uk/pdbsum/1B4G
PDBsum	1B4I	http://www.ebi.ac.uk/pdbsum/1B4I
PDBsum	1ZTN	http://www.ebi.ac.uk/pdbsum/1ZTN
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01491	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01491
PRINTS	PR01498	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01498
PRINTS	PR01583	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01583
PSORT	swissprot:KCNC4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNC4_HUMAN
PSORT-B	swissprot:KCNC4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNC4_HUMAN
PSORT2	swissprot:KCNC4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNC4_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF02214	http://pfam.xfam.org/family/PF02214
Pfam	PF11404	http://pfam.xfam.org/family/PF11404
PharmGKB	PA30028	http://www.pharmgkb.org/do/serve?objId=PA30028&objCls=Gene
Phobius	swissprot:KCNC4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNC4_HUMAN
PhylomeDB	Q03721	http://phylomedb.org/?seqid=Q03721
ProteinModelPortal	Q03721	http://www.proteinmodelportal.org/query/uniprot/Q03721
PubMed	10048926	http://www.ncbi.nlm.nih.gov/pubmed/10048926
PubMed	1381835	http://www.ncbi.nlm.nih.gov/pubmed/1381835
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	7993631	http://www.ncbi.nlm.nih.gov/pubmed/7993631
PubMed	9000078	http://www.ncbi.nlm.nih.gov/pubmed/9000078
PubMed	9649584	http://www.ncbi.nlm.nih.gov/pubmed/9649584
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
RefSeq	NP_001034663	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001034663
RefSeq	NP_004969	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004969
SMART	SM00225	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225
SMR	Q03721	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q03721
STRING	9606.ENSP00000358802	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000358802&targetmode=cogs
SUPFAM	SSF54695	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54695
UCSC	uc001dzg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001dzg&org=rat
UniGene	Hs.153521	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.153521
UniProtKB	KCNC4_HUMAN	http://www.uniprot.org/uniprot/KCNC4_HUMAN
UniProtKB-AC	Q03721	http://www.uniprot.org/uniprot/Q03721
charge	swissprot:KCNC4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNC4_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG3713	http://eggnogapi.embl.de/nog_data/html/tree/KOG3713
epestfind	swissprot:KCNC4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNC4_HUMAN
garnier	swissprot:KCNC4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNC4_HUMAN
helixturnhelix	swissprot:KCNC4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNC4_HUMAN
hmoment	swissprot:KCNC4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNC4_HUMAN
iep	swissprot:KCNC4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNC4_HUMAN
inforesidue	swissprot:KCNC4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNC4_HUMAN
neXtProt	NX_Q03721	http://www.nextprot.org/db/entry/NX_Q03721
octanol	swissprot:KCNC4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNC4_HUMAN
pepcoil	swissprot:KCNC4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNC4_HUMAN
pepdigest	swissprot:KCNC4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNC4_HUMAN
pepinfo	swissprot:KCNC4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNC4_HUMAN
pepnet	swissprot:KCNC4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNC4_HUMAN
pepstats	swissprot:KCNC4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNC4_HUMAN
pepwheel	swissprot:KCNC4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNC4_HUMAN
pepwindow	swissprot:KCNC4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNC4_HUMAN
sigcleave	swissprot:KCNC4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNC4_HUMAN
## Database	ID	URL or Descriptions
# AltName	IMA7_HUMAN	Karyopherin subunit alpha-6
# BioGrid	117163	69
# ChiTaRS	KPNA6	human
# Ensembl	ENST00000373625	ENSP00000362728; ENSG00000025800
# ExpressionAtlas	O60684	baseline and differential
# FUNCTION	IMA7_HUMAN	Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO 0000269|PubMed 10523667}. 
# GO_component	GO:0005643	nuclear pore; IBA:GO_Central.
# GO_component	GO:0005654	nucleoplasm; IBA:GO_Central.
# GO_component	GO:0005829	cytosol; IBA:GO_Central.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_function	GO:0008139	nuclear localization sequence binding; IBA:GO_Central.
# GO_function	GO:0008565	protein transporter activity; IBA:GO_Central.
# GO_process	GO:0006607	NLS-bearing protein import into nucleus; TAS:ProtInc.
# GO_process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
# GO_process	GO:0060135	maternal process involved in female pregnancy; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.25.10.10	-; 1.
# Genevisible	O60684	HS
# HGNC	HGNC:6399	KPNA6
# INTERACTION	IMA7_HUMAN	P46087 NOP2; NbExp=3; IntAct=EBI-359923, EBI-356811; Q9UKX7 NUP50; NbExp=5; IntAct=EBI-359923, EBI-2371082; Q15637 SF1; NbExp=4; IntAct=EBI-359923, EBI-744603; Q16594 TAF9; NbExp=3; IntAct=EBI-359923, EBI-712521; 
# IntAct	O60684	41
# InterPro	IPR000225	Armadillo
# InterPro	IPR002652	Importin-a_IBB
# InterPro	IPR011989	ARM-like
# InterPro	IPR016024	ARM-type_fold
# InterPro	IPR024931	Importing_su_alpha
# InterPro	IPR032413	Arm_3
# MIM	610563	gene
# Organism	IMA7_HUMAN	Homo sapiens (Human)
# PDB	4UAD	X-ray; 2.42 A; A=59-536
# PIRSF	PIRSF005673	Importin_alpha
# PROSITE	PS50176	ARM_REPEAT; 3
# PROSITE	PS51214	IBB
# Pfam	PF00514	Arm; 8
# Pfam	PF01749	IBB
# Pfam	PF16186	Arm_3
# Proteomes	UP000005640	Chromosome 1
# RecName	IMA7_HUMAN	Importin subunit alpha-7
# RefSeq	NP_036448	NM_012316.4
# SIMILARITY	Belongs to the importin alpha family. {ECO	0000305}. 
# SIMILARITY	Contains 1 IBB domain. {ECO:0000255|PROSITE- ProRule	PRU00561}.
# SIMILARITY	Contains 10 ARM repeats. {ECO:0000255|PROSITE- ProRule	PRU00259}. 
# SMART	SM00185	ARM; 8
# SUBUNIT	Interacts with ZIC3 (By similarity). Forms a complex with importin subunit beta-1. {ECO:0000250, ECO	0000269|PubMed:10523667}. 
# SUPFAM	SSF48371	SSF48371
# TCDB	1.I.1.1	the nuclear pore complex (npc) family
# TISSUE SPECIFICITY	Widely expressed. {ECO:0000269|PubMed	10523667}. 
# UCSC	uc001bug	human
# eggNOG	COG5064	LUCA
# eggNOG	KOG0166	Eukaryota
BLAST	swissprot:IMA7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:IMA7_HUMAN
BioCyc	ZFISH:ENSG00000025800-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000025800-MONOMER
COXPRESdb	23633	http://coxpresdb.jp/data/gene/23633.shtml
CleanEx	HS_KPNA6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KPNA6
DIP	DIP-27609N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-27609N
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1128/MCB.19.11.7782	http://dx.doi.org/10.1128/MCB.19.11.7782
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF060543	http://www.ebi.ac.uk/ena/data/view/AF060543
EMBL	AK315490	http://www.ebi.ac.uk/ena/data/view/AK315490
EMBL	AL049795	http://www.ebi.ac.uk/ena/data/view/AL049795
EMBL	AL049795	http://www.ebi.ac.uk/ena/data/view/AL049795
EMBL	AL445248	http://www.ebi.ac.uk/ena/data/view/AL445248
EMBL	AL445248	http://www.ebi.ac.uk/ena/data/view/AL445248
EMBL	BC020520	http://www.ebi.ac.uk/ena/data/view/BC020520
EMBL	BT009843	http://www.ebi.ac.uk/ena/data/view/BT009843
EMBL	CH471059	http://www.ebi.ac.uk/ena/data/view/CH471059
EMBL	CH471059	http://www.ebi.ac.uk/ena/data/view/CH471059
Ensembl	ENST00000373625	http://www.ensembl.org/id/ENST00000373625
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005643	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005643
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0008139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008139
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0006607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006607
GO_process	GO:0045944	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045944
GO_process	GO:0060135	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060135
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
GeneCards	KPNA6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KPNA6
GeneID	23633	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23633
GeneTree	ENSGT00760000119094	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119094
HGNC	HGNC:6399	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6399
HOVERGEN	HBG001846	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG001846&db=HOVERGEN
HPA	HPA018863	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA018863
InParanoid	O60684	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O60684
IntAct	O60684	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O60684*
InterPro	IPR000225	http://www.ebi.ac.uk/interpro/entry/IPR000225
InterPro	IPR002652	http://www.ebi.ac.uk/interpro/entry/IPR002652
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
InterPro	IPR024931	http://www.ebi.ac.uk/interpro/entry/IPR024931
InterPro	IPR032413	http://www.ebi.ac.uk/interpro/entry/IPR032413
Jabion	23633	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=23633
KEGG_Gene	hsa:23633	http://www.genome.jp/dbget-bin/www_bget?hsa:23633
MIM	610563	http://www.ncbi.nlm.nih.gov/omim/610563
MINT	MINT-1144956	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1144956
OMA	HNDNKVA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HNDNKVA
OrthoDB	EOG091G095Z	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G095Z
PDB	4UAD	http://www.ebi.ac.uk/pdbe-srv/view/entry/4UAD
PDBsum	4UAD	http://www.ebi.ac.uk/pdbsum/4UAD
PROSITE	PS50176	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50176
PROSITE	PS51214	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51214
PSORT	swissprot:IMA7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:IMA7_HUMAN
PSORT-B	swissprot:IMA7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:IMA7_HUMAN
PSORT2	swissprot:IMA7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:IMA7_HUMAN
Pfam	PF00514	http://pfam.xfam.org/family/PF00514
Pfam	PF01749	http://pfam.xfam.org/family/PF01749
Pfam	PF16186	http://pfam.xfam.org/family/PF16186
PharmGKB	PA30190	http://www.pharmgkb.org/do/serve?objId=PA30190&objCls=Gene
Phobius	swissprot:IMA7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:IMA7_HUMAN
PhylomeDB	O60684	http://phylomedb.org/?seqid=O60684
ProteinModelPortal	O60684	http://www.proteinmodelportal.org/query/uniprot/O60684
PubMed	10523667	http://www.ncbi.nlm.nih.gov/pubmed/10523667
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
RefSeq	NP_036448	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_036448
SMART	SM00185	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00185
SMR	O60684	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O60684
STRING	9606.ENSP00000362728	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000362728&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
TCDB	1.I.1.1	http://www.tcdb.org/search/result.php?tc=1.I.1.1
UCSC	uc001bug	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001bug&org=rat
UniGene	Hs.470588	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.470588
UniGene	Hs.711019	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.711019
UniProtKB	IMA7_HUMAN	http://www.uniprot.org/uniprot/IMA7_HUMAN
UniProtKB-AC	O60684	http://www.uniprot.org/uniprot/O60684
charge	swissprot:IMA7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:IMA7_HUMAN
eggNOG	COG5064	http://eggnogapi.embl.de/nog_data/html/tree/COG5064
eggNOG	KOG0166	http://eggnogapi.embl.de/nog_data/html/tree/KOG0166
epestfind	swissprot:IMA7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:IMA7_HUMAN
garnier	swissprot:IMA7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:IMA7_HUMAN
helixturnhelix	swissprot:IMA7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:IMA7_HUMAN
hmoment	swissprot:IMA7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:IMA7_HUMAN
iep	swissprot:IMA7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:IMA7_HUMAN
inforesidue	swissprot:IMA7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:IMA7_HUMAN
neXtProt	NX_O60684	http://www.nextprot.org/db/entry/NX_O60684
octanol	swissprot:IMA7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:IMA7_HUMAN
pepcoil	swissprot:IMA7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:IMA7_HUMAN
pepdigest	swissprot:IMA7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:IMA7_HUMAN
pepinfo	swissprot:IMA7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:IMA7_HUMAN
pepnet	swissprot:IMA7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:IMA7_HUMAN
pepstats	swissprot:IMA7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:IMA7_HUMAN
pepwheel	swissprot:IMA7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:IMA7_HUMAN
pepwindow	swissprot:IMA7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:IMA7_HUMAN
sigcleave	swissprot:IMA7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:IMA7_HUMAN
## Database	ID	URL or Descriptions
# AltName	SC5A4_HUMAN	Sodium/glucose cotransporter 3
# AltName	SC5A4_HUMAN	Solute carrier family 5 member 4
# Ensembl	ENST00000266086	ENSP00000266086; ENSG00000100191
# FUNCTION	SC5A4_HUMAN	Sodium-dependent glucose transporter. {ECO 0000250}. 
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	SC5A4_HUMAN	GO 0005412 glucose sodium symporter activity; IBA GO_Central.
# GO_process	GO:0006814	sodium ion transport; IBA:GO_Central.
# GO_process	GO:1904659	glucose transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9NY91	HS
# HGNC	HGNC:11039	SLC5A4
# InterPro	IPR001734	Na/solute_symporter
# InterPro	IPR018212	Na/solute_symporter_CS
# KEGG_Brite	ko02001	Solute carrier family
# Organism	SC5A4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11819	PTHR11819; 2
# PROSITE	PS00456	NA_SOLUT_SYMP_1
# PROSITE	PS00457	NA_SOLUT_SYMP_2
# PROSITE	PS50283	NA_SOLUT_SYMP_3
# Pfam	PF00474	SSF
# Proteomes	UP000005640	Chromosome 22
# Reactome	R-HSA-189200	Hexose transport
# Reactome	R-HSA-428808	Na+-dependent glucose transporters
# Reactome	R-HSA-429593	Inositol transporters
# RecName	SC5A4_HUMAN	Low affinity sodium-glucose cotransporter
# RefSeq	NP_055042	NM_014227.2
# SIMILARITY	Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	SC5A4_HUMAN	Membrane; Multi-pass membrane protein. 
# TCDB	2.A.21.3.18:the solute	sodium symporter (sss) family
# TIGRFAMs	TIGR00813	sss
# UCSC	uc003ami	human
# eggNOG	COG4146	LUCA
# eggNOG	ENOG410IP49	Eukaryota
BLAST	swissprot:SC5A4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SC5A4_HUMAN
BioCyc	ZFISH:ENSG00000100191-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000100191-MONOMER
COXPRESdb	6527	http://coxpresdb.jp/data/gene/6527.shtml
CleanEx	HS_SLC5A4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC5A4
DOI	10.1038/990031	http://dx.doi.org/10.1038/990031
EMBL	AJ133127	http://www.ebi.ac.uk/ena/data/view/AJ133127
EMBL	AL008723	http://www.ebi.ac.uk/ena/data/view/AL008723
EMBL	U41897	http://www.ebi.ac.uk/ena/data/view/U41897
Ensembl	ENST00000266086	http://www.ensembl.org/id/ENST00000266086
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005412	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005412
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:1904659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1904659
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC5A4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC5A4
GeneID	6527	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6527
GeneTree	ENSGT00760000118955	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118955
HGNC	HGNC:11039	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11039
HOGENOM	HOG000025422	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000025422&db=HOGENOM6
HOVERGEN	HBG052859	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052859&db=HOVERGEN
InParanoid	Q9NY91	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NY91
IntAct	Q9NY91	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NY91*
InterPro	IPR001734	http://www.ebi.ac.uk/interpro/entry/IPR001734
InterPro	IPR018212	http://www.ebi.ac.uk/interpro/entry/IPR018212
Jabion	6527	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6527
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6527	http://www.genome.jp/dbget-bin/www_bget?hsa:6527
KEGG_Orthology	KO:K14384	http://www.genome.jp/dbget-bin/www_bget?KO:K14384
OMA	YPMLVME	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YPMLVME
OrthoDB	EOG091G077U	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G077U
PANTHER	PTHR11819	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11819
PROSITE	PS00456	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00456
PROSITE	PS00457	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00457
PROSITE	PS50283	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50283
PSORT	swissprot:SC5A4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SC5A4_HUMAN
PSORT-B	swissprot:SC5A4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SC5A4_HUMAN
PSORT2	swissprot:SC5A4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SC5A4_HUMAN
Pfam	PF00474	http://pfam.xfam.org/family/PF00474
PharmGKB	PA35904	http://www.pharmgkb.org/do/serve?objId=PA35904&objCls=Gene
Phobius	swissprot:SC5A4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SC5A4_HUMAN
PhylomeDB	Q9NY91	http://phylomedb.org/?seqid=Q9NY91
ProteinModelPortal	Q9NY91	http://www.proteinmodelportal.org/query/uniprot/Q9NY91
PubMed	10591208	http://www.ncbi.nlm.nih.gov/pubmed/10591208
Reactome	R-HSA-189200	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-189200
Reactome	R-HSA-428808	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428808
Reactome	R-HSA-429593	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-429593
RefSeq	NP_055042	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055042
STRING	9606.ENSP00000266086	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000266086&targetmode=cogs
TCDB	2.A.21.3.18	http://www.tcdb.org/search/result.php?tc=2.A.21.3.18
TIGRFAMs	TIGR00813	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00813
UCSC	uc003ami	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ami&org=rat
UniGene	Hs.130101	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.130101
UniProtKB	SC5A4_HUMAN	http://www.uniprot.org/uniprot/SC5A4_HUMAN
UniProtKB-AC	Q9NY91	http://www.uniprot.org/uniprot/Q9NY91
charge	swissprot:SC5A4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SC5A4_HUMAN
eggNOG	COG4146	http://eggnogapi.embl.de/nog_data/html/tree/COG4146
eggNOG	ENOG410IP49	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IP49
epestfind	swissprot:SC5A4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SC5A4_HUMAN
garnier	swissprot:SC5A4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SC5A4_HUMAN
helixturnhelix	swissprot:SC5A4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SC5A4_HUMAN
hmoment	swissprot:SC5A4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SC5A4_HUMAN
iep	swissprot:SC5A4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SC5A4_HUMAN
inforesidue	swissprot:SC5A4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SC5A4_HUMAN
neXtProt	NX_Q9NY91	http://www.nextprot.org/db/entry/NX_Q9NY91
octanol	swissprot:SC5A4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SC5A4_HUMAN
pepcoil	swissprot:SC5A4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SC5A4_HUMAN
pepdigest	swissprot:SC5A4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SC5A4_HUMAN
pepinfo	swissprot:SC5A4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SC5A4_HUMAN
pepnet	swissprot:SC5A4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SC5A4_HUMAN
pepstats	swissprot:SC5A4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SC5A4_HUMAN
pepwheel	swissprot:SC5A4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SC5A4_HUMAN
pepwindow	swissprot:SC5A4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SC5A4_HUMAN
sigcleave	swissprot:SC5A4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SC5A4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TRPM2_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=TRPM2-L; IsoId=O94759-1; Sequence=Displayed; Name=2; IsoId=O94759-2; Sequence=VSP_006574, VSP_006575; Name=3; Synonyms=TRPM2-S; IsoId=O94759-3; Sequence=VSP_013018; 
# AltName	Estrogen-responsive element-associated gene 1 protein {ECO	0000303|Ref.9}
# AltName	Long transient receptor potential channel 2 {ECO:0000303|PubMed	11960981}
# AltName	Transient receptor potential channel 7 {ECO:0000303|PubMed	9806837}
# AltName	Transient receptor potential melastatin 2 {ECO:0000303|PubMed	27383051}
# CAUTION	TRPM2_HUMAN	The isolated nudix hydrolase domain was shown to have low catalytic activity with ADP-ribose upon heterologous expression (PubMed 11385575). However, a more recent publication demonstrates that the nudix hydrolase domain lacks enzyme activity and suggests that spontaneous degradation of the substrate underlies the previously reported low activity (PubMed 27383051). {ECO 0000269|PubMed 11385575, ECO 0000269|PubMed 27383051}. 
# CCDS	CCDS13710	-. [O94759-1]
# DOMAIN	TRPM2_HUMAN	The cytosolic nudix box binds ADP-ribose and is required for channel activation by ADP-ribose (PubMed 15561722, PubMed 16601673). {ECO 0000269|PubMed 15561722, ECO 0000269|PubMed 16601673}. 
# ENZYME REGULATION	TRPM2_HUMAN	Inactivated by exposure to extracellular pH between 4.0 and 6.5; irreversibly inactivated when open channels are exposed to extracellular pH between 4.0 and 6.5, while pre- exposure of closed channels to extracellular pH 5.5 gives rise to currents that rapidly inactivate, but protects against irreversible inactivation (PubMed 20660597). Inactivated by intracellular ATP (PubMed 11509734). Activated by arachidonic acid (PubMed 11804595). {ECO 0000269|PubMed 11509734, ECO 0000269|PubMed 11804595, ECO 0000269|PubMed 20660597}. 
# Ensembl	ENST00000300481	ENSP00000300481; ENSG00000142185. [O94759-2]
# Ensembl	ENST00000300482	ENSP00000300482; ENSG00000142185. [O94759-1]
# Ensembl	ENST00000397928	ENSP00000381023; ENSG00000142185. [O94759-1]
# ExpressionAtlas	O94759	baseline and differential
# FUNCTION	TRPM2_HUMAN	Isoform 1  Nonselective, voltage-independent cation channel that mediates Na(+) and Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels (PubMed 11960981, PubMed 12594222, PubMed 11385575, PubMed 11509734, PubMed 11804595, PubMed 15561722, PubMed 16601673, PubMed 19171771, PubMed 20660597, PubMed 27383051, PubMed 27068538). Extracellular calcium passes through the channel and increases channel activity by binding to the cytoplasmic domain and stabilizing the channel in an open conformation (PubMed 19171771). Also contributes to Ca(2+) release from intracellular stores in response to ADP-ribose (PubMed 19454650). Plays a role in numerous processes that involve signaling via intracellular Ca(2+) levels (Probable). Besides, mediates the release of lysosomal Zn(2+) stores in response to reactive oxygen species, leading to increased cytosolic Zn(2+) levels (PubMed 25562606, PubMed 27068538). Activated by moderate heat (35 to 40 degrees Celsius) (PubMed 16601673). Activated by intracellular ADP-ribose, beta-NAD (NAD(+)) and similar compounds, and by oxidative stress caused by reactive oxygen or nitrogen species (PubMed 11960981, PubMed 11385575, PubMed 11509734, PubMed 11804595, PubMed 15561722, PubMed 16601673, PubMed 19171771, PubMed 27383051, PubMed 27068538). The precise physiological activators are under debate; the true, physiological activators may be ADP-ribose and ADP-ribose-2'-phosphate (PubMed 20650899, PubMed 25918360). Activation by ADP-ribose and beta-NAD is strongly increased by moderate heat (35 to 40 degrees Celsius) (PubMed 16601673). Likewise, reactive oxygen species lower the threshold for activation by moderate heat (37 degrees Celsius) (PubMed 22493272). Plays a role in mediating behavorial and physiological responses to moderate heat and thereby contributes to body temperature homeostasis. Plays a role in insulin secretion, a process that requires increased cytoplasmic Ca(2+) levels (By similarity). Required for normal IFNG and cytokine secretion and normal innate immune immunity in response to bacterial infection. Required for normal phagocytosis and cytokine release by macrophages exposed to zymosan (in vitro). Plays a role in dendritic cell differentiation and maturation, and in dendritic cell chemotaxis via its role in regulating cytoplasmic Ca(2+) levels (By similarity). Plays a role in the regulation of the reorganization of the actin cytoskeleton and filopodia formation in response to reactive oxygen species via its role in increasing cytoplasmic Ca(2+) and Zn(2+) levels (PubMed 27068538). Confers susceptibility to cell death following oxidative stress (PubMed 12594222, PubMed 25562606). {ECO 0000250|UniProtKB Q91YD4, ECO 0000269|PubMed 11385575, ECO 0000269|PubMed 11509734, ECO 0000269|PubMed 11804595, ECO 0000269|PubMed 11960981, ECO 0000269|PubMed 12594222, ECO 0000269|PubMed 15561722, ECO 0000269|PubMed 16601673, ECO 0000269|PubMed 19171771, ECO 0000269|PubMed 19454650, ECO 0000269|PubMed 20650899, ECO 0000269|PubMed 20660597, ECO 0000269|PubMed 22493272, ECO 0000269|PubMed 25562606, ECO 0000269|PubMed 25918360, ECO 0000269|PubMed 27068538, ECO 0000269|PubMed 27383051, ECO 0000305}. 
# FUNCTION	TRPM2_HUMAN	Isoform 2  Lacks cation channel activity. Does not mediate cation transport in response to oxidative stress or ADP- ribose. {ECO 0000269|PubMed 11960981}. 
# FUNCTION	TRPM2_HUMAN	Isoform 3  Lacks cation channel activity and negatively regulates the channel activity of isoform 1. Negatively regulates susceptibility to cell death in reposponse to oxidative stress. {ECO 0000269|PubMed 12594222}. 
# GO_component	GO:0005764	lysosome; IDA:UniProtKB.
# GO_component	GO:0005765	lysosomal membrane; ISS:UniProtKB.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IMP:UniProtKB.
# GO_component	GO:0030659	cytoplasmic vesicle membrane; ISS:UniProtKB.
# GO_component	GO:0043005	neuron projection; IEA:Ensembl.
# GO_component	GO:0043204	perikaryon; IEA:UniProtKB-SubCell.
# GO_function	GO:0005261	cation channel activity; IMP:UniProtKB.
# GO_function	GO:0005262	calcium channel activity; TAS:Reactome.
# GO_function	GO:0005272	sodium channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0005509	calcium ion binding; IMP:UniProtKB.
# GO_function	GO:0015278	calcium-release channel activity; IMP:UniProtKB.
# GO_function	GO:0099604	ligand-gated calcium channel activity; IDA:UniProtKB.
# GO_process	GO:0001659	temperature homeostasis; ISS:UniProtKB.
# GO_process	GO:0002407	dendritic cell chemotaxis; ISS:UniProtKB.
# GO_process	GO:0006816	calcium ion transport; TAS:ProtInc.
# GO_process	GO:0014074	response to purine-containing compound; IMP:UniProtKB.
# GO_process	GO:0032024	positive regulation of insulin secretion; IEA:Ensembl.
# GO_process	GO:0035584	calcium-mediated signaling using intracellular calcium source; ISS:UniProtKB.
# GO_process	GO:0044849	estrous cycle; IEA:Ensembl.
# GO_process	GO:0051209	release of sequestered calcium ion into cytosol; IMP:UniProtKB.
# GO_process	GO:0051489	regulation of filopodium assembly; IMP:UniProtKB.
# GO_process	GO:0070301	cellular response to hydrogen peroxide; IDA:UniProtKB.
# GO_process	GO:0070588	calcium ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0071277	cellular response to calcium ion; IMP:UniProtKB.
# GO_process	GO:0071415	cellular response to purine-containing compound; ISS:UniProtKB.
# GO_process	GO:0071502	cellular response to temperature stimulus; ISS:UniProtKB.
# GO_process	GO:0071577	zinc II ion transmembrane transport; IMP:UniProtKB.
# GO_process	GO:0097028	dendritic cell differentiation; ISS:UniProtKB.
# GO_process	GO:0097553	calcium ion transmembrane import into cytosol; IMP:UniProtKB.
# GO_process	GO:0098703	calcium ion import across plasma membrane; ISS:UniProtKB.
# GO_process	GO:1903223	positive regulation of oxidative stress-induced neuron death; IEA:Ensembl.
# GO_process	GO:2000249	regulation of actin cytoskeleton reorganization; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005764	lysosome
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048870	cell motility
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.90.79.10	-; 1.
# Genevisible	O94759	HS
# HGNC	HGNC:12339	TRPM2
# InterPro	IPR000086	NUDIX_hydrolase_dom
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR015797	NUDIX_hydrolase_dom-like
# InterPro	IPR029594	TRPM2
# KEGG_Brite	ko04040	Ion channels
# MIM	603749	gene
# Organism	TRPM2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR13800:SF2	PTHR13800:SF2
# PROSITE	PS51462	NUDIX
# Pfam	PF00520	Ion_trans
# Proteomes	UP000005640	Chromosome 21
# Reactome	R-HSA-3295583	TRP channels
# Reactome	R-HSA-6798695	Neutrophil degranulation
# RecName	TRPM2_HUMAN	Transient receptor potential cation channel subfamily M member 2
# RefSeq	NP_001307279	NM_001320350.1
# RefSeq	NP_001307280	NM_001320351.1
# RefSeq	NP_003298	NM_003307.3
# RefSeq	XP_005261228	XM_005261171.3. [O94759-1]
# SEQUENCE CAUTION	Sequence=BAB64300.1; Type=Frameshift; Positions=1227, 1237; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 nudix hydrolase domain. {ECO:0000255|PROSITE-ProRule	PRU00794}. 
# SUBCELLULAR LOCATION	TRPM2_HUMAN	Cell membrane {ECO 0000269|PubMed 11385575, ECO 0000269|PubMed 11509734, ECO 0000269|PubMed 11804595, ECO 0000269|PubMed 12594222, ECO 0000269|PubMed 15561722, ECO 0000269|PubMed 16601673, ECO 0000269|PubMed 19171771, ECO 0000269|PubMed 20650899, ECO 0000269|PubMed 20660597, ECO 0000269|PubMed 22493272, ECO 0000269|PubMed 25918360, ECO 0000269|PubMed 27068538, ECO 0000269|PubMed 27383051}; Multi- pass membrane protein {ECO 0000255}. Perikaryon {ECO 0000250|UniProtKB E9PTA2}. Cell projection {ECO 0000250|UniProtKB E9PTA2}. Cytoplasmic vesicle {ECO 0000250|UniProtKB E9PTA2}. Lysosome {ECO 0000269|PubMed 27068538}. Note=Detected at the cell membrane and in intracellular vesicles in cortical neurons. Detected on neuronal cell bodies and neurites (By similarity). Detected on the cell membrane in polymorphonuclear neutrophils. Detected on cytoplasmic vesicles and lysosomes in immature bone marrow dendritic cells (By similarity). {ECO 0000250|UniProtKB E9PTA2, ECO 0000250|UniProtKB Q91YD4}. 
# SUBCELLULAR LOCATION	TRPM2_HUMAN	Isoform 1  Cell membrane {ECO 0000269|PubMed 11960981, ECO 0000269|PubMed 12594222}; Multi- pass membrane protein {ECO 0000255}. 
# SUBCELLULAR LOCATION	TRPM2_HUMAN	Isoform 2  Cell membrane {ECO 0000269|PubMed 11960981}; Multi-pass membrane protein {ECO 0000255}. 
# SUBCELLULAR LOCATION	TRPM2_HUMAN	Isoform 3  Cell membrane {ECO 0000269|PubMed 12594222}; Multi-pass membrane protein {ECO 0000255}. 
# SUBUNIT	Isoform 1 can interact with isoform 3. This interaction decreases calcium influx through isoform 1 and suppresses susceptibility to oxidative stress-induced cell death. {ECO:0000269|PubMed	12594222}. 
# SUPFAM	SSF55811	SSF55811
# TCDB	1.A.4.5	the transient receptor potential ca(2+) channel (trp-cc) family
# TISSUE SPECIFICITY	TRPM2_HUMAN	Highly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes. {ECO 0000269|PubMed 11385575, ECO 0000269|PubMed 11509734}. 
# UCSC	uc002zet	human. [O94759-1]
# WEB RESOURCE	TRPM2_HUMAN	Name=NIEHS-SNPs; URL="http //egp.gs.washington.edu/data/trpm2/";
# eggNOG	ENOG410XR5B	LUCA
# eggNOG	KOG3614	Eukaryota
# eggNOG	KOG4195	Eukaryota
BLAST	swissprot:TRPM2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TRPM2_HUMAN
BioCyc	ZFISH:HS06903-MONOMER	http://biocyc.org/getid?id=ZFISH:HS06903-MONOMER
COXPRESdb	7226	http://coxpresdb.jp/data/gene/7226.shtml
CleanEx	HS_TRPC7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TRPC7
CleanEx	HS_TRPM2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TRPM2
DOI	10.1006/geno.1998.5551	http://dx.doi.org/10.1006/geno.1998.5551
DOI	10.1016/S1097-2765(01)00438-5	http://dx.doi.org/10.1016/S1097-2765(01)00438-5
DOI	10.1016/j.bbrc.2005.01.086	http://dx.doi.org/10.1016/j.bbrc.2005.01.086
DOI	10.1038/35012518	http://dx.doi.org/10.1038/35012518
DOI	10.1038/35079100	http://dx.doi.org/10.1038/35079100
DOI	10.1038/sj.emboj.7601083	http://dx.doi.org/10.1038/sj.emboj.7601083
DOI	10.1042/BJ20140747	http://dx.doi.org/10.1042/BJ20140747
DOI	10.1073/pnas.1114193109	http://dx.doi.org/10.1073/pnas.1114193109
DOI	10.1074/jbc.M109.066464	http://dx.doi.org/10.1074/jbc.M109.066464
DOI	10.1074/jbc.M110.139774	http://dx.doi.org/10.1074/jbc.M110.139774
DOI	10.1074/jbc.M112096200	http://dx.doi.org/10.1074/jbc.M112096200
DOI	10.1074/jbc.M300298200	http://dx.doi.org/10.1074/jbc.M300298200
DOI	10.1074/jbc.M411446200	http://dx.doi.org/10.1074/jbc.M411446200
DOI	10.1085/jgp.200810109	http://dx.doi.org/10.1085/jgp.200810109
DOI	10.1085/jgp.201511377	http://dx.doi.org/10.1085/jgp.201511377
DOI	10.1126/science.1062473	http://dx.doi.org/10.1126/science.1062473
DOI	10.1126/scisignal.2000278	http://dx.doi.org/10.1126/scisignal.2000278
DOI	10.1242/jcs.179796	http://dx.doi.org/10.1242/jcs.179796
DOI	10.7554/eLife.17600	http://dx.doi.org/10.7554/eLife.17600
EMBL	AB001535	http://www.ebi.ac.uk/ena/data/view/AB001535
EMBL	AB017549	http://www.ebi.ac.uk/ena/data/view/AB017549
EMBL	AB166745	http://www.ebi.ac.uk/ena/data/view/AB166745
EMBL	AJ417076	http://www.ebi.ac.uk/ena/data/view/AJ417076
EMBL	AJ878416	http://www.ebi.ac.uk/ena/data/view/AJ878416
EMBL	AP001754	http://www.ebi.ac.uk/ena/data/view/AP001754
EMBL	AY603182	http://www.ebi.ac.uk/ena/data/view/AY603182
EMBL	CH471079	http://www.ebi.ac.uk/ena/data/view/CH471079
EMBL	CH471079	http://www.ebi.ac.uk/ena/data/view/CH471079
EMBL	DQ012935	http://www.ebi.ac.uk/ena/data/view/DQ012935
Ensembl	ENST00000300481	http://www.ensembl.org/id/ENST00000300481
Ensembl	ENST00000300482	http://www.ensembl.org/id/ENST00000300482
Ensembl	ENST00000397928	http://www.ensembl.org/id/ENST00000397928
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0030659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030659
GO_component	GO:0043005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043005
GO_component	GO:0043204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043204
GO_function	GO:0005261	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005261
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0005272	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005272
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0015278	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015278
GO_function	GO:0099604	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0099604
GO_process	GO:0001659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001659
GO_process	GO:0002407	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002407
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0014074	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014074
GO_process	GO:0032024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032024
GO_process	GO:0035584	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035584
GO_process	GO:0044849	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044849
GO_process	GO:0051209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051209
GO_process	GO:0051489	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051489
GO_process	GO:0070301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070301
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:0071277	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071277
GO_process	GO:0071415	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071415
GO_process	GO:0071502	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071502
GO_process	GO:0071577	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071577
GO_process	GO:0097028	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097028
GO_process	GO:0097553	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097553
GO_process	GO:0098703	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098703
GO_process	GO:1903223	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903223
GO_process	GO:2000249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000249
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.90.79.10	http://www.cathdb.info/version/latest/superfamily/3.90.79.10
GeneCards	TRPM2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TRPM2
GeneID	7226	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7226
GeneTree	ENSGT00760000119127	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119127
HGNC	HGNC:12339	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:12339
HOGENOM	HOG000236350	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236350&db=HOGENOM6
HOVERGEN	HBG055825	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG055825&db=HOVERGEN
HPA	HPA030976	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA030976
HPA	HPA035260	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035260
InParanoid	O94759	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O94759
InterPro	IPR000086	http://www.ebi.ac.uk/interpro/entry/IPR000086
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR015797	http://www.ebi.ac.uk/interpro/entry/IPR015797
InterPro	IPR029594	http://www.ebi.ac.uk/interpro/entry/IPR029594
Jabion	7226	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7226
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:7226	http://www.genome.jp/dbget-bin/www_bget?hsa:7226
KEGG_Orthology	KO:K04977	http://www.genome.jp/dbget-bin/www_bget?KO:K04977
MIM	603749	http://www.ncbi.nlm.nih.gov/omim/603749
PANTHER	PTHR13800:SF2	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13800:SF2
PROSITE	PS51462	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51462
PSORT	swissprot:TRPM2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TRPM2_HUMAN
PSORT-B	swissprot:TRPM2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TRPM2_HUMAN
PSORT2	swissprot:TRPM2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TRPM2_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
PharmGKB	PA37012	http://www.pharmgkb.org/do/serve?objId=PA37012&objCls=Gene
Phobius	swissprot:TRPM2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TRPM2_HUMAN
PhylomeDB	O94759	http://phylomedb.org/?seqid=O94759
ProteinModelPortal	O94759	http://www.proteinmodelportal.org/query/uniprot/O94759
PubMed	10830953	http://www.ncbi.nlm.nih.gov/pubmed/10830953
PubMed	11385575	http://www.ncbi.nlm.nih.gov/pubmed/11385575
PubMed	11509734	http://www.ncbi.nlm.nih.gov/pubmed/11509734
PubMed	11804595	http://www.ncbi.nlm.nih.gov/pubmed/11804595
PubMed	11960981	http://www.ncbi.nlm.nih.gov/pubmed/11960981
PubMed	12594222	http://www.ncbi.nlm.nih.gov/pubmed/12594222
PubMed	15561722	http://www.ncbi.nlm.nih.gov/pubmed/15561722
PubMed	15708008	http://www.ncbi.nlm.nih.gov/pubmed/15708008
PubMed	16601673	http://www.ncbi.nlm.nih.gov/pubmed/16601673
PubMed	19171771	http://www.ncbi.nlm.nih.gov/pubmed/19171771
PubMed	19454650	http://www.ncbi.nlm.nih.gov/pubmed/19454650
PubMed	20650899	http://www.ncbi.nlm.nih.gov/pubmed/20650899
PubMed	20660597	http://www.ncbi.nlm.nih.gov/pubmed/20660597
PubMed	22493272	http://www.ncbi.nlm.nih.gov/pubmed/22493272
PubMed	25562606	http://www.ncbi.nlm.nih.gov/pubmed/25562606
PubMed	25918360	http://www.ncbi.nlm.nih.gov/pubmed/25918360
PubMed	27068538	http://www.ncbi.nlm.nih.gov/pubmed/27068538
PubMed	27383051	http://www.ncbi.nlm.nih.gov/pubmed/27383051
PubMed	9806837	http://www.ncbi.nlm.nih.gov/pubmed/9806837
Reactome	R-HSA-3295583	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3295583
Reactome	R-HSA-6798695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6798695
RefSeq	NP_001307279	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001307279
RefSeq	NP_001307280	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001307280
RefSeq	NP_003298	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003298
RefSeq	XP_005261228	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005261228
SMR	O94759	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O94759
STRING	9606.ENSP00000300482	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000300482&targetmode=cogs
SUPFAM	SSF55811	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55811
TCDB	1.A.4.5	http://www.tcdb.org/search/result.php?tc=1.A.4.5
UCSC	uc002zet	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002zet&org=rat
UniGene	Hs.369759	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.369759
UniProtKB	TRPM2_HUMAN	http://www.uniprot.org/uniprot/TRPM2_HUMAN
UniProtKB-AC	O94759	http://www.uniprot.org/uniprot/O94759
charge	swissprot:TRPM2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TRPM2_HUMAN
eggNOG	ENOG410XR5B	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XR5B
eggNOG	KOG3614	http://eggnogapi.embl.de/nog_data/html/tree/KOG3614
eggNOG	KOG4195	http://eggnogapi.embl.de/nog_data/html/tree/KOG4195
epestfind	swissprot:TRPM2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TRPM2_HUMAN
garnier	swissprot:TRPM2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TRPM2_HUMAN
helixturnhelix	swissprot:TRPM2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRPM2_HUMAN
hmoment	swissprot:TRPM2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TRPM2_HUMAN
iep	swissprot:TRPM2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TRPM2_HUMAN
inforesidue	swissprot:TRPM2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TRPM2_HUMAN
neXtProt	NX_O94759	http://www.nextprot.org/db/entry/NX_O94759
octanol	swissprot:TRPM2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TRPM2_HUMAN
pepcoil	swissprot:TRPM2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TRPM2_HUMAN
pepdigest	swissprot:TRPM2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TRPM2_HUMAN
pepinfo	swissprot:TRPM2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TRPM2_HUMAN
pepnet	swissprot:TRPM2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TRPM2_HUMAN
pepstats	swissprot:TRPM2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TRPM2_HUMAN
pepwheel	swissprot:TRPM2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TRPM2_HUMAN
pepwindow	swissprot:TRPM2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TRPM2_HUMAN
sigcleave	swissprot:TRPM2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TRPM2_HUMAN
## Database	ID	URL or Descriptions
# AltName	LRC8A_HUMAN	Leucine-rich repeat-containing protein 8A
# AltName	LRC8A_HUMAN	Swelling protein 1
# BioGrid	121126	23
# ChiTaRS	LRRC8A	human
# DISEASE	LRC8A_HUMAN	Agammaglobulinemia 5, autosomal dominant (AGM5) [MIM 613506]  A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. {ECO 0000269|PubMed 14660746}. Note=The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving LRRC8 has been found in a patient with congenital agammaglobulinemia. Translocation t(9;20)(q33.2;q12). The translocation truncates the LRRC8 gene, resulting in deletion of the eighth, ninth, and half of the seventh LRR domains. 
# Ensembl	ENST00000259324	ENSP00000259324; ENSG00000136802
# Ensembl	ENST00000372599	ENSP00000361680; ENSG00000136802
# Ensembl	ENST00000372600	ENSP00000361682; ENSG00000136802
# ExpressionAtlas	Q8IWT6	baseline and differential
# FUNCTION	LRC8A_HUMAN	Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine (PubMed 24725410, PubMed 24790029, PubMed 26530471, PubMed 26824658). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed 26530471). Required for in vivo channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed 24790029, PubMed 26824658). Can form functional channels by itself (in vitro) (PubMed 26824658). Involved in B-cell development  required for the pro-B cell to pre-B cell transition (PubMed 14660746). Also required for T-cell development (By similarity). {ECO 0000250|UniProtKB Q80WG5, ECO 0000269|PubMed 14660746, ECO 0000269|PubMed 24725410, ECO 0000269|PubMed 24790029, ECO 0000269|PubMed 26530471, ECO 0000269|PubMed 26824658}. 
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0009986	cell surface; IDA:MGI.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0034702	ion channel complex; IDA:UniProtKB.
# GO_function	GO:0005225	volume-sensitive anion channel activity; IMP:UniProtKB.
# GO_process	GO:0002329	pre-B cell differentiation; ISS:UniProtKB.
# GO_process	GO:0006820	anion transport; IMP:UniProtKB.
# GO_process	GO:0006884	cell volume homeostasis; IMP:UniProtKB.
# GO_process	GO:0006970	response to osmotic stress; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0042592	homeostatic process
# Gene3D	3.80.10.10	-; 2.
# Genevisible	Q8IWT6	HS
# HGNC	HGNC:19027	LRRC8A
# IntAct	Q8IWT6	4
# InterPro	IPR001611	Leu-rich_rpt
# InterPro	IPR003591	Leu-rich_rpt_typical-subtyp
# InterPro	IPR021040	LRRC8_Pannexin-like
# InterPro	IPR032675	L_dom-like
# KEGG_Disease	H00085	[Primary immunodeficiency] Leucine-rich repeat-containing 8
# MIM	608360	gene
# MIM	613506	phenotype
# Organism	LRC8A_HUMAN	Homo sapiens (Human)
# Orphanet	33110	Autosomal agammaglobulinemia
# PROSITE	PS51450	LRR; 11
# PTM	LRC8A_HUMAN	N-glycosylated. {ECO 0000269|PubMed 24790029}. 
# Pfam	PF12534	Pannexin_like
# Pfam	PF13855	LRR_8; 3
# Proteomes	UP000005640	Chromosome 9
# RecName	LRC8A_HUMAN	Volume-regulated anion channel subunit LRRC8A
# RefSeq	NP_001120716	NM_001127244.1
# RefSeq	NP_001120717	NM_001127245.1
# RefSeq	NP_062540	NM_019594.3
# RefSeq	XP_005252152	XM_005252095.2
# RefSeq	XP_005252153	XM_005252096.3
# RefSeq	XP_006717249	XM_006717186.2
# RefSeq	XP_011517165	XM_011518863.1
# RefSeq	XP_011517166	XM_011518864.2
# RefSeq	XP_011517167	XM_011518865.2
# SEQUENCE CAUTION	Sequence=AAQ88653.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA92675.1; Type=Erroneous initiation; Evidence={ECO	0000305}; Sequence=BAC11161.1; Type=Erroneous initiation; Evidence={ECO:0000305}; 
# SIMILARITY	Belongs to the LRRC8 family. {ECO	0000305}. 
# SIMILARITY	Contains 17 LRR (leucine-rich) repeats. {ECO	0000305}. 
# SMART	SM00369	LRR_TYP; 8
# SUBCELLULAR LOCATION	LRC8A_HUMAN	Cell membrane {ECO 0000269|PubMed 24725410, ECO 0000269|PubMed 24782309, ECO 0000269|PubMed 24790029, ECO 0000269|PubMed 26824658}; Multi-pass membrane protein {ECO 0000269|PubMed 24725410, ECO 0000269|PubMed 24782309, ECO 0000269|PubMed 24790029}. Note=The leucine-rich repeat (LRR) domain is on the cytoplasmic side of the cell membrane. {ECO 0000269|PubMed 24782309}. 
# SUBUNIT	LRC8A_HUMAN	Heterooligomer; heterooligomerizes with other LRRC8 proteins (LRRC8B, LRRC8C, LRRC8D and/or LRRC8E), possibly to form a heterohexamer (PubMed 24782309, PubMed 24790029, PubMed 26824658). In vivo, the subunit composition may depend primarily on expression levels, and heterooligomeric channels containing various proportions of the different LRRC8 proteins may coexist (Probable). {ECO 0000269|PubMed 24782309, ECO 0000269|PubMed 24790029, ECO 0000269|PubMed 26824658, ECO 0000305}. 
# SUPFAM	SSF52058	SSF52058
# TCDB	1.A.25.3	the gap junction-forming innexin (innexin) family
# TISSUE SPECIFICITY	LRC8A_HUMAN	Expressed in brain, kidney, ovary, lung, liver, heart, and fetal brain and liver. Found at high levels in bone marrow; lower levels are detected in peripheral blood cells. Expressed on T-cells as well as on B-lineage cells. {ECO 0000269|PubMed 10718198, ECO 0000269|PubMed 14660746}. 
# UCSC	uc004bwl	human
# WEB RESOURCE	LRC8A_HUMAN	Name=LRRC8Abase; Note=LRRC8A mutation db; URL="http //structure.bmc.lu.se/idbase/LRRC8Abase/";
# eggNOG	COG4886	LUCA
# eggNOG	KOG0619	Eukaryota
BLAST	swissprot:LRC8A_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:LRC8A_HUMAN
COXPRESdb	56262	http://coxpresdb.jp/data/gene/56262.shtml
CleanEx	HS_LRRC8A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_LRRC8A
DIP	DIP-61360N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-61360N
DOI	10.1002/bies.201100173	http://dx.doi.org/10.1002/bies.201100173
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.cell.2014.03.024	http://dx.doi.org/10.1016/j.cell.2014.03.024
DOI	10.1016/j.cell.2015.12.031	http://dx.doi.org/10.1016/j.cell.2015.12.031
DOI	10.1016/j.molimm.2004.04.001	http://dx.doi.org/10.1016/j.molimm.2004.04.001
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1074/jbc.M114.571257	http://dx.doi.org/10.1074/jbc.M114.571257
DOI	10.1093/dnares/7.1.65	http://dx.doi.org/10.1093/dnares/7.1.65
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1252826	http://dx.doi.org/10.1126/science.1252826
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1172/JCI18937	http://dx.doi.org/10.1172/JCI18937
DOI	10.15252/embj.201592409	http://dx.doi.org/10.15252/embj.201592409
EMBL	AB037858	http://www.ebi.ac.uk/ena/data/view/AB037858
EMBL	AK074723	http://www.ebi.ac.uk/ena/data/view/AK074723
EMBL	AL672142	http://www.ebi.ac.uk/ena/data/view/AL672142
EMBL	AY143166	http://www.ebi.ac.uk/ena/data/view/AY143166
EMBL	AY358286	http://www.ebi.ac.uk/ena/data/view/AY358286
EMBL	BC051322	http://www.ebi.ac.uk/ena/data/view/BC051322
Ensembl	ENST00000259324	http://www.ensembl.org/id/ENST00000259324
Ensembl	ENST00000372599	http://www.ensembl.org/id/ENST00000372599
Ensembl	ENST00000372600	http://www.ensembl.org/id/ENST00000372600
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0034702	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034702
GO_function	GO:0005225	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005225
GO_process	GO:0002329	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002329
GO_process	GO:0006820	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006820
GO_process	GO:0006884	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006884
GO_process	GO:0006970	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006970
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
Gene3D	3.80.10.10	http://www.cathdb.info/version/latest/superfamily/3.80.10.10
GeneCards	LRRC8A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=LRRC8A
GeneID	56262	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56262
GeneTree	ENSGT00840000129676	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00840000129676
HGNC	HGNC:19027	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:19027
HOGENOM	HOG000231806	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231806&db=HOGENOM6
HOVERGEN	HBG052360	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052360&db=HOVERGEN
HPA	HPA016811	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA016811
InParanoid	Q8IWT6	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8IWT6
IntAct	Q8IWT6	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8IWT6*
InterPro	IPR001611	http://www.ebi.ac.uk/interpro/entry/IPR001611
InterPro	IPR003591	http://www.ebi.ac.uk/interpro/entry/IPR003591
InterPro	IPR021040	http://www.ebi.ac.uk/interpro/entry/IPR021040
InterPro	IPR032675	http://www.ebi.ac.uk/interpro/entry/IPR032675
Jabion	56262	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=56262
KEGG_Disease	H00085	http://www.genome.jp/dbget-bin/www_bget?H00085
KEGG_Gene	hsa:56262	http://www.genome.jp/dbget-bin/www_bget?hsa:56262
MIM	608360	http://www.ncbi.nlm.nih.gov/omim/608360
MIM	613506	http://www.ncbi.nlm.nih.gov/omim/613506
OMA	HIAYIPM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HIAYIPM
Orphanet	33110	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=33110
OrthoDB	EOG091G01ER	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01ER
PROSITE	PS51450	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51450
PSORT	swissprot:LRC8A_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:LRC8A_HUMAN
PSORT-B	swissprot:LRC8A_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:LRC8A_HUMAN
PSORT2	swissprot:LRC8A_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:LRC8A_HUMAN
Pfam	PF12534	http://pfam.xfam.org/family/PF12534
Pfam	PF13855	http://pfam.xfam.org/family/PF13855
PharmGKB	PA134909315	http://www.pharmgkb.org/do/serve?objId=PA134909315&objCls=Gene
Phobius	swissprot:LRC8A_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:LRC8A_HUMAN
PhylomeDB	Q8IWT6	http://phylomedb.org/?seqid=Q8IWT6
ProteinModelPortal	Q8IWT6	http://www.proteinmodelportal.org/query/uniprot/Q8IWT6
PubMed	10718198	http://www.ncbi.nlm.nih.gov/pubmed/10718198
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	14660746	http://www.ncbi.nlm.nih.gov/pubmed/14660746
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
PubMed	15183935	http://www.ncbi.nlm.nih.gov/pubmed/15183935
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	22532330	http://www.ncbi.nlm.nih.gov/pubmed/22532330
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24725410	http://www.ncbi.nlm.nih.gov/pubmed/24725410
PubMed	24782309	http://www.ncbi.nlm.nih.gov/pubmed/24782309
PubMed	24790029	http://www.ncbi.nlm.nih.gov/pubmed/24790029
PubMed	26530471	http://www.ncbi.nlm.nih.gov/pubmed/26530471
PubMed	26824658	http://www.ncbi.nlm.nih.gov/pubmed/26824658
RefSeq	NP_001120716	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001120716
RefSeq	NP_001120717	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001120717
RefSeq	NP_062540	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_062540
RefSeq	XP_005252152	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005252152
RefSeq	XP_005252153	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005252153
RefSeq	XP_006717249	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006717249
RefSeq	XP_011517165	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011517165
RefSeq	XP_011517166	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011517166
RefSeq	XP_011517167	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011517167
SMART	SM00369	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00369
STRING	9606.ENSP00000259324	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000259324&targetmode=cogs
SUPFAM	SSF52058	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52058
TCDB	1.A.25.3	http://www.tcdb.org/search/result.php?tc=1.A.25.3
UCSC	uc004bwl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004bwl&org=rat
UniGene	Hs.643600	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.643600
UniProtKB	LRC8A_HUMAN	http://www.uniprot.org/uniprot/LRC8A_HUMAN
UniProtKB-AC	Q8IWT6	http://www.uniprot.org/uniprot/Q8IWT6
charge	swissprot:LRC8A_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:LRC8A_HUMAN
eggNOG	COG4886	http://eggnogapi.embl.de/nog_data/html/tree/COG4886
eggNOG	KOG0619	http://eggnogapi.embl.de/nog_data/html/tree/KOG0619
epestfind	swissprot:LRC8A_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:LRC8A_HUMAN
garnier	swissprot:LRC8A_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:LRC8A_HUMAN
helixturnhelix	swissprot:LRC8A_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:LRC8A_HUMAN
hmoment	swissprot:LRC8A_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:LRC8A_HUMAN
iep	swissprot:LRC8A_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:LRC8A_HUMAN
inforesidue	swissprot:LRC8A_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:LRC8A_HUMAN
neXtProt	NX_Q8IWT6	http://www.nextprot.org/db/entry/NX_Q8IWT6
octanol	swissprot:LRC8A_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:LRC8A_HUMAN
pepcoil	swissprot:LRC8A_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:LRC8A_HUMAN
pepdigest	swissprot:LRC8A_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:LRC8A_HUMAN
pepinfo	swissprot:LRC8A_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:LRC8A_HUMAN
pepnet	swissprot:LRC8A_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:LRC8A_HUMAN
pepstats	swissprot:LRC8A_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:LRC8A_HUMAN
pepwheel	swissprot:LRC8A_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:LRC8A_HUMAN
pepwindow	swissprot:LRC8A_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:LRC8A_HUMAN
sigcleave	swissprot:LRC8A_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:LRC8A_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	NPT2B_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=NaPi-3b; IsoId=O95436-1; Sequence=Displayed; Name=2; Synonyms=NaPi-2b, NaPi-IIb; IsoId=O95436-2; Sequence=VSP_016755; 
# AltName	NPT2B_HUMAN	Na(+)-dependent phosphate cotransporter 2B
# AltName	NPT2B_HUMAN	NaPi3b
# AltName	NPT2B_HUMAN	Sodium/phosphate cotransporter 2B
# AltName	NPT2B_HUMAN	Solute carrier family 34 member 2
# BIOPHYSICOCHEMICAL PROPERTIES	pH dependence: Optimum pH is 6.6. {ECO	0000269|PubMed:10329428}; 
# BioGrid	115819	14
# CCDS	CCDS3435	-. [O95436-1]
# CCDS	CCDS54750	-. [O95436-2]
# ChiTaRS	SLC34A2	human
# DISEASE	NPT2B_HUMAN	Note=A chromosomal aberration involving SLC34A2 is found in a glioblastoma multiforme cell line U-118MG. Results in the formation of a SLC34A2-ROS1 chimeric protein that retains a constitutive kinase activity. {ECO 0000269|PubMed 12661006}. 
# DISEASE	NPT2B_HUMAN	Pulmonary alveolar microlithiasis (PALM) [MIM 265100]  Rare disease characterized by the deposition of calcium phosphate microliths throughout the lungs. Most patients are asymptomatic for several years or even for decades and generally, the diagnosis is incidental to clinical investigations unrelated to the disease. Cases with early-onset or rapid progression are rare. A 'sandstorm-appearing' chest roentgenogram is a typical diagnostic finding. The onset of this potentially lethal disease varies from the neonatal period to old age and the disease follows a long- term, progressive course, resulting in a slow deterioration of lung functions. Pulmonary alveolar microlithiasis is a recessive monogenic disease with full penetrance. {ECO 0000269|PubMed 16960801}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000382051	ENSP00000371483; ENSG00000157765. [O95436-1]
# Ensembl	ENST00000503434	ENSP00000423021; ENSG00000157765. [O95436-2]
# Ensembl	ENST00000504570	ENSP00000425501; ENSG00000157765. [O95436-2]
# ExpressionAtlas	O95436	baseline and differential
# FUNCTION	NPT2B_HUMAN	May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli. 
# GO_component	GO:0005737	cytoplasm; IBA:GO_Central.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; NAS:UniProtKB.
# GO_component	GO:0005903	brush border; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IDA:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_component	GO:0031526	brush border membrane; ISS:UniProtKB.
# GO_component	GO:0031982	vesicle; IDA:UniProtKB.
# GO_function	GO:0005315	inorganic phosphate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015321	sodium-dependent phosphate transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0031402	sodium ion binding; IDA:UniProtKB.
# GO_function	GO:0042301	phosphate ion binding; IDA:UniProtKB.
# GO_function	NPT2B_HUMAN	GO 0005436 sodium phosphate symporter activity; IDA UniProtKB.
# GO_process	GO:0001701	in utero embryonic development; IEA:Ensembl.
# GO_process	GO:0006817	phosphate ion transport; IDA:UniProtKB.
# GO_process	GO:0030643	cellular phosphate ion homeostasis; IDA:UniProtKB.
# GO_process	GO:0043627	response to estrogen; IEP:UniProtKB.
# GO_process	GO:0044267	cellular protein metabolic process; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009790	embryo development
# GOslim_process	GO:0042592	homeostatic process
# Genevisible	O95436	HS
# HGNC	HGNC:11020	SLC34A2
# INDUCTION	Down-regulated by EGF. {ECO:0000269|PubMed	11171583}. 
# InterPro	IPR003841	Na/Pi_transpt
# InterPro	IPR029852	Na/Pi_transpt_2B
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H00014	[Cancer] Non-small cell lung cancer
# KEGG_Disease	H01298	[Lung disease] Pulmonary alveolar microlithiasis (PALM)
# MIM	265100	phenotype
# MIM	604217	gene
# Organism	NPT2B_HUMAN	Homo sapiens (Human)
# Orphanet	60025	Pulmonary alveolar microlithiasis
# PANTHER	PTHR10010:SF23	PTHR10010:SF23; 2
# Pfam	PF02690	Na_Pi_cotrans; 2
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-427589	Type II Na+/Pi cotransporters
# Reactome	R-HSA-5683826	Surfactant metabolism
# RecName	NPT2B_HUMAN	Sodium-dependent phosphate transport protein 2B
# RefSeq	NP_001171469	NM_001177998.1
# RefSeq	NP_001171470	NM_001177999.1
# RefSeq	NP_006415	NM_006424.2
# SEQUENCE CAUTION	Sequence=BAC11354.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the SLC34A transporter family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	NPT2B_HUMAN	Membrane; Multi-pass membrane protein. 
# TCDB	2.A.58.1:the phosphate	na(+) symporter (pnas) family
# TIGRFAMs	TIGR01013	2a58
# TISSUE SPECIFICITY	NPT2B_HUMAN	Highly expressed in lung. Also detected in pancreas, kidney, small intestine, ovary, testis, prostate and mammary gland. In lung, it is found in alveolar type II cells but not in bronchiolar epithelium. {ECO 0000269|PubMed 10329428, ECO 0000269|PubMed 10610722}. 
# UCSC	uc003grr	human. [O95436-1]
# eggNOG	COG1283	LUCA
# eggNOG	ENOG410IE8P	Eukaryota
BLAST	swissprot:NPT2B_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NPT2B_HUMAN
BioCyc	ZFISH:ENSG00000157765-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000157765-MONOMER
COG	COG1283	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1283
COXPRESdb	10568	http://coxpresdb.jp/data/gene/10568.shtml
CleanEx	HS_SLC34A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC34A2
DOI	10.1002/gcc.10207	http://dx.doi.org/10.1002/gcc.10207
DOI	10.1006/bbrc.1999.0666	http://dx.doi.org/10.1006/bbrc.1999.0666
DOI	10.1006/geno.1999.6009	http://dx.doi.org/10.1006/geno.1999.6009
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1086/508263	http://dx.doi.org/10.1086/508263
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC092436	http://www.ebi.ac.uk/ena/data/view/AC092436
EMBL	AF111856	http://www.ebi.ac.uk/ena/data/view/AF111856
EMBL	AF146796	http://www.ebi.ac.uk/ena/data/view/AF146796
EMBL	AH011306	http://www.ebi.ac.uk/ena/data/view/AH011306
EMBL	AK075015	http://www.ebi.ac.uk/ena/data/view/AK075015
EMBL	BC142704	http://www.ebi.ac.uk/ena/data/view/BC142704
EMBL	BC146666	http://www.ebi.ac.uk/ena/data/view/BC146666
Ensembl	ENST00000382051	http://www.ensembl.org/id/ENST00000382051
Ensembl	ENST00000503434	http://www.ensembl.org/id/ENST00000503434
Ensembl	ENST00000504570	http://www.ensembl.org/id/ENST00000504570
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005903	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005903
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0031526	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031526
GO_component	GO:0031982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031982
GO_function	GO:0005315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005315
GO_function	GO:0005436	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005436
GO_function	GO:0015321	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015321
GO_function	GO:0031402	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031402
GO_function	GO:0042301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042301
GO_process	GO:0001701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001701
GO_process	GO:0006817	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006817
GO_process	GO:0030643	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030643
GO_process	GO:0043627	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043627
GO_process	GO:0044267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044267
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009790
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GeneCards	SLC34A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC34A2
GeneID	10568	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10568
GeneTree	ENSGT00390000005032	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000005032
HGNC	HGNC:11020	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11020
HOGENOM	HOG000006550	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006550&db=HOGENOM6
HOVERGEN	HBG006527	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006527&db=HOVERGEN
HPA	HPA037989	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA037989
InParanoid	O95436	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O95436
IntAct	O95436	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O95436*
InterPro	IPR003841	http://www.ebi.ac.uk/interpro/entry/IPR003841
InterPro	IPR029852	http://www.ebi.ac.uk/interpro/entry/IPR029852
Jabion	10568	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10568
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00014	http://www.genome.jp/dbget-bin/www_bget?H00014
KEGG_Disease	H01298	http://www.genome.jp/dbget-bin/www_bget?H01298
KEGG_Gene	hsa:10568	http://www.genome.jp/dbget-bin/www_bget?hsa:10568
KEGG_Orthology	KO:K14683	http://www.genome.jp/dbget-bin/www_bget?KO:K14683
MIM	265100	http://www.ncbi.nlm.nih.gov/omim/265100
MIM	604217	http://www.ncbi.nlm.nih.gov/omim/604217
OMA	KTECTAL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KTECTAL
Orphanet	60025	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=60025
OrthoDB	EOG091G0DR5	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0DR5
PANTHER	PTHR10010:SF23	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10010:SF23
PSORT	swissprot:NPT2B_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NPT2B_HUMAN
PSORT-B	swissprot:NPT2B_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NPT2B_HUMAN
PSORT2	swissprot:NPT2B_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NPT2B_HUMAN
Pfam	PF02690	http://pfam.xfam.org/family/PF02690
PharmGKB	PA35888	http://www.pharmgkb.org/do/serve?objId=PA35888&objCls=Gene
Phobius	swissprot:NPT2B_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NPT2B_HUMAN
PhylomeDB	O95436	http://phylomedb.org/?seqid=O95436
ProteinModelPortal	O95436	http://www.proteinmodelportal.org/query/uniprot/O95436
PubMed	10329428	http://www.ncbi.nlm.nih.gov/pubmed/10329428
PubMed	10610722	http://www.ncbi.nlm.nih.gov/pubmed/10610722
PubMed	11171583	http://www.ncbi.nlm.nih.gov/pubmed/11171583
PubMed	12661006	http://www.ncbi.nlm.nih.gov/pubmed/12661006
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	16960801	http://www.ncbi.nlm.nih.gov/pubmed/16960801
Reactome	R-HSA-427589	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-427589
Reactome	R-HSA-5683826	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5683826
RefSeq	NP_001171469	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001171469
RefSeq	NP_001171470	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001171470
RefSeq	NP_006415	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006415
STRING	9606.ENSP00000371483	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000371483&targetmode=cogs
STRING	COG1283	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1283&targetmode=cogs
TCDB	2.A.58.1	http://www.tcdb.org/search/result.php?tc=2.A.58.1
TIGRFAMs	TIGR01013	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01013
UCSC	uc003grr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003grr&org=rat
UniGene	Hs.479372	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.479372
UniProtKB	NPT2B_HUMAN	http://www.uniprot.org/uniprot/NPT2B_HUMAN
UniProtKB-AC	O95436	http://www.uniprot.org/uniprot/O95436
charge	swissprot:NPT2B_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NPT2B_HUMAN
eggNOG	COG1283	http://eggnogapi.embl.de/nog_data/html/tree/COG1283
eggNOG	ENOG410IE8P	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IE8P
epestfind	swissprot:NPT2B_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NPT2B_HUMAN
garnier	swissprot:NPT2B_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NPT2B_HUMAN
helixturnhelix	swissprot:NPT2B_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NPT2B_HUMAN
hmoment	swissprot:NPT2B_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NPT2B_HUMAN
iep	swissprot:NPT2B_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NPT2B_HUMAN
inforesidue	swissprot:NPT2B_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NPT2B_HUMAN
neXtProt	NX_O95436	http://www.nextprot.org/db/entry/NX_O95436
octanol	swissprot:NPT2B_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NPT2B_HUMAN
pepcoil	swissprot:NPT2B_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NPT2B_HUMAN
pepdigest	swissprot:NPT2B_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NPT2B_HUMAN
pepinfo	swissprot:NPT2B_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NPT2B_HUMAN
pepnet	swissprot:NPT2B_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NPT2B_HUMAN
pepstats	swissprot:NPT2B_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NPT2B_HUMAN
pepwheel	swissprot:NPT2B_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NPT2B_HUMAN
pepwindow	swissprot:NPT2B_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NPT2B_HUMAN
sigcleave	swissprot:NPT2B_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NPT2B_HUMAN
## Database	ID	URL or Descriptions
# AltName	ABCD4_HUMAN	PMP70-related protein
# AltName	ABCD4_HUMAN	Peroxisomal membrane protein 1-like
# AltName	ABCD4_HUMAN	Peroxisomal membrane protein 69
# BioGrid	111784	13
# ChiTaRS	ABCD4	human
# DISEASE	ABCD4_HUMAN	Methylmalonic aciduria and homocystinuria type cblJ (MAHCJ) [MIM 614857]  A disorder of cobalamin metabolism characterized by decreased levels of the coenzymes adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl). Clinical features include feeding difficulties, poor growth, hypotonia, lethargy, anemia, and developmental delay. {ECO 0000269|PubMed 22922874}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000356924	ENSP00000349396; ENSG00000119688
# ExpressionAtlas	O14678	baseline and differential
# FUNCTION	ABCD4_HUMAN	May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm. {ECO 0000269|PubMed 22922874}. 
# GO_component	GO:0005765	lysosomal membrane; TAS:Reactome.
# GO_component	GO:0005777	peroxisome; IDA:UniProtKB.
# GO_component	GO:0005778	peroxisomal membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005789	endoplasmic reticulum membrane; IEA:Ensembl.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0043190	ATP-binding cassette (ABC) transporter complex; NAS:UniProtKB.
# GO_function	GO:0005524	ATP binding; NAS:UniProtKB.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; NAS:UniProtKB.
# GO_process	GO:0009235	cobalamin metabolic process; IMP:UniProtKB.
# GO_process	GO:0055085	transmembrane transport; NAS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005777	peroxisome
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 2.
# Genevisible	O14678	HS
# HGNC	HGNC:68	ABCD4
# IntAct	O14678	4
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR011527	ABC1_TM_dom
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Disease	H00174	[Inherited metabolic disease; Nervous system disease] Methylmalonic aciduria (MMA)
# KEGG_Pathway	ko02010	ABC transporters
# KEGG_Pathway	ko04146	Peroxisome
# MIM	603214	gene
# MIM	614857	phenotype
# Organism	ABCD4_HUMAN	Homo sapiens (Human)
# Orphanet	369955	Methylmalonic acidemia with homocystinuria, type cblJ
# PIR	JC5604	JC5604
# PROSITE	PS00211	ABC_TRANSPORTER_1
# PROSITE	PS50893	ABC_TRANSPORTER_2
# PROSITE	PS50929	ABC_TM1F
# Pfam	PF00005	ABC_tran
# Pfam	PF06472	ABC_membrane_2
# Proteomes	UP000005640	Chromosome 14
# Reactome	R-HSA-196741	Cobalamin (Cbl, vitamin B12) transport and metabolism
# RecName	ABCD4_HUMAN	ATP-binding cassette sub-family D member 4
# RefSeq	NP_005041	NM_005050.3
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule	PRU00441}. 
# SIMILARITY	Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA
# SUBCELLULAR LOCATION	ABCD4_HUMAN	Peroxisome membrane; Multi-pass membrane protein. 
# SUBUNIT	Homodimer or heterodimer. {ECO	0000305}. 
# SUPFAM	SSF52540	SSF52540
# SUPFAM	SSF90123	SSF90123
# TCDB	3.A.1.203	the atp-binding cassette (abc) superfamily
# TISSUE SPECIFICITY	ABCD4_HUMAN	Ubiquitous. 
# UCSC	uc001xpr	human
# WEB RESOURCE	ABCD4_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=O14678";
# eggNOG	COG4178	LUCA
# eggNOG	KOG0060	Eukaryota
BLAST	swissprot:ABCD4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCD4_HUMAN
BioCyc	ZFISH:ENSG00000119688-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000119688-MONOMER
COXPRESdb	5826	http://coxpresdb.jp/data/gene/5826.shtml
CleanEx	HS_ABCD4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCD4
DOI	10.1006/bbrc.1997.7102	http://dx.doi.org/10.1006/bbrc.1997.7102
DOI	10.1007/s100380200041	http://dx.doi.org/10.1007/s100380200041
DOI	10.1016/S0014-5793(98)00354-8	http://dx.doi.org/10.1016/S0014-5793(98)00354-8
DOI	10.1038/ng.2386	http://dx.doi.org/10.1038/ng.2386
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/hmg/6.11.1925	http://dx.doi.org/10.1093/hmg/6.11.1925
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF009746	http://www.ebi.ac.uk/ena/data/view/AF009746
EMBL	AK291332	http://www.ebi.ac.uk/ena/data/view/AK291332
EMBL	BC012815	http://www.ebi.ac.uk/ena/data/view/BC012815
EMBL	BT007412	http://www.ebi.ac.uk/ena/data/view/BT007412
EMBL	CR457104	http://www.ebi.ac.uk/ena/data/view/CR457104
EMBL	Y14318	http://www.ebi.ac.uk/ena/data/view/Y14318
EMBL	Y14319	http://www.ebi.ac.uk/ena/data/view/Y14319
EMBL	Y14320	http://www.ebi.ac.uk/ena/data/view/Y14320
EMBL	Y14321	http://www.ebi.ac.uk/ena/data/view/Y14321
EMBL	Y14322	http://www.ebi.ac.uk/ena/data/view/Y14322
EMBL	Y14323	http://www.ebi.ac.uk/ena/data/view/Y14323
Ensembl	ENST00000356924	http://www.ensembl.org/id/ENST00000356924
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005777	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005777
GO_component	GO:0005778	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005778
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0043190	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GO_process	GO:0009235	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009235
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005777	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005777
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCD4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCD4
GeneID	5826	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5826
GeneTree	ENSGT00390000003950	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000003950
HGNC	HGNC:68	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:68
HOGENOM	HOG000007546	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007546&db=HOGENOM6
HOVERGEN	HBG106060	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG106060&db=HOVERGEN
HPA	HPA003396	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA003396
InParanoid	O14678	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O14678
IntAct	O14678	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O14678*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR011527	http://www.ebi.ac.uk/interpro/entry/IPR011527
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	5826	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=5826
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Disease	H00174	http://www.genome.jp/dbget-bin/www_bget?H00174
KEGG_Gene	hsa:5826	http://www.genome.jp/dbget-bin/www_bget?hsa:5826
KEGG_Orthology	KO:K05678	http://www.genome.jp/dbget-bin/www_bget?KO:K05678
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
KEGG_Pathway	ko04146	http://www.genome.jp/kegg-bin/show_pathway?ko04146
MIM	603214	http://www.ncbi.nlm.nih.gov/omim/603214
MIM	614857	http://www.ncbi.nlm.nih.gov/omim/614857
OMA	FRARVYY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FRARVYY
Orphanet	369955	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=369955
OrthoDB	EOG091G03HJ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G03HJ
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PROSITE	PS50929	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929
PSORT	swissprot:ABCD4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCD4_HUMAN
PSORT-B	swissprot:ABCD4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCD4_HUMAN
PSORT2	swissprot:ABCD4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCD4_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF06472	http://pfam.xfam.org/family/PF06472
PharmGKB	PA24403	http://www.pharmgkb.org/do/serve?objId=PA24403&objCls=Gene
Phobius	swissprot:ABCD4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCD4_HUMAN
PhylomeDB	O14678	http://phylomedb.org/?seqid=O14678
ProteinModelPortal	O14678	http://www.proteinmodelportal.org/query/uniprot/O14678
PubMed	12111378	http://www.ncbi.nlm.nih.gov/pubmed/12111378
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	22922874	http://www.ncbi.nlm.nih.gov/pubmed/22922874
PubMed	9266848	http://www.ncbi.nlm.nih.gov/pubmed/9266848
PubMed	9302272	http://www.ncbi.nlm.nih.gov/pubmed/9302272
PubMed	9599016	http://www.ncbi.nlm.nih.gov/pubmed/9599016
Reactome	R-HSA-196741	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-196741
RefSeq	NP_005041	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005041
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
STRING	9606.ENSP00000349396	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000349396&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
SUPFAM	SSF90123	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123
TCDB	3.A.1.203	http://www.tcdb.org/search/result.php?tc=3.A.1.203
UCSC	uc001xpr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001xpr&org=rat
UniGene	Hs.94395	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.94395
UniProtKB	ABCD4_HUMAN	http://www.uniprot.org/uniprot/ABCD4_HUMAN
UniProtKB-AC	O14678	http://www.uniprot.org/uniprot/O14678
charge	swissprot:ABCD4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCD4_HUMAN
eggNOG	COG4178	http://eggnogapi.embl.de/nog_data/html/tree/COG4178
eggNOG	KOG0060	http://eggnogapi.embl.de/nog_data/html/tree/KOG0060
epestfind	swissprot:ABCD4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCD4_HUMAN
garnier	swissprot:ABCD4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCD4_HUMAN
helixturnhelix	swissprot:ABCD4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCD4_HUMAN
hmoment	swissprot:ABCD4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCD4_HUMAN
iep	swissprot:ABCD4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCD4_HUMAN
inforesidue	swissprot:ABCD4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCD4_HUMAN
neXtProt	NX_O14678	http://www.nextprot.org/db/entry/NX_O14678
octanol	swissprot:ABCD4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCD4_HUMAN
pepcoil	swissprot:ABCD4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCD4_HUMAN
pepdigest	swissprot:ABCD4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCD4_HUMAN
pepinfo	swissprot:ABCD4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCD4_HUMAN
pepnet	swissprot:ABCD4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCD4_HUMAN
pepstats	swissprot:ABCD4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCD4_HUMAN
pepwheel	swissprot:ABCD4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCD4_HUMAN
pepwindow	swissprot:ABCD4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCD4_HUMAN
sigcleave	swissprot:ABCD4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCD4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AP2S1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P53680-1; Sequence=Displayed; Name=2; IsoId=P53680-2; Sequence=VSP_017352; 
# AltName	AP2S1_HUMAN	Adaptor protein complex AP-2 subunit sigma
# AltName	AP2S1_HUMAN	Adaptor-related protein complex 2 subunit sigma
# AltName	AP2S1_HUMAN	Clathrin assembly protein 2 sigma small chain
# AltName	AP2S1_HUMAN	Clathrin coat assembly protein AP17
# AltName	AP2S1_HUMAN	Clathrin coat-associated protein AP17
# AltName	AP2S1_HUMAN	HA2 17 kDa subunit
# AltName	AP2S1_HUMAN	Plasma membrane adaptor AP-2 17 kDa protein
# AltName	AP2S1_HUMAN	Sigma2-adaptin
# BioGrid	107589	43
# CCDS	CCDS12693	-. [P53680-2]
# CCDS	CCDS33062	-. [P53680-1]
# ChiTaRS	AP2S1	human
# DISEASE	AP2S1_HUMAN	Hypocalciuric hypercalcemia, familial 3 (HHC3) [MIM 600740]  A form of hypocalciuric hypercalcemia, a disorder of mineral homeostasis that is transmitted as an autosomal dominant trait with a high degree of penetrance. It is characterized biochemically by lifelong elevation of serum calcium concentrations and is associated with inappropriately low urinary calcium excretion and a normal or mildly elevated circulating parathyroid hormone level. Hypermagnesemia is typically present. Affected individuals are usually asymptomatic and the disorder is considered benign. However, chondrocalcinosis and pancreatitis occur in some adults. {ECO 0000269|PubMed 23222959, ECO 0000269|PubMed 24081735}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000263270	ENSP00000263270; ENSG00000042753. [P53680-1]
# Ensembl	ENST00000601649	ENSP00000470898; ENSG00000042753. [P53680-2]
# ExpressionAtlas	P53680	baseline and differential
# FUNCTION	AP2S1_HUMAN	Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). May also play a role in extracellular calcium homeostasis. {ECO 0000250, ECO 0000269|PubMed 14745134, ECO 0000269|PubMed 15473838, ECO 0000269|PubMed 19033387, ECO 0000269|PubMed 23222959}. 
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0030122	AP-2 adaptor complex; TAS:UniProtKB.
# GO_component	GO:0030666	endocytic vesicle membrane; TAS:Reactome.
# GO_component	GO:0030669	clathrin-coated endocytic vesicle membrane; TAS:Reactome.
# GO_component	GO:0036020	endolysosome membrane; TAS:Reactome.
# GO_function	GO:0005215	transporter activity; NAS:ProtInc.
# GO_function	GO:0008565	protein transporter activity; NAS:UniProtKB.
# GO_process	GO:0006886	intracellular protein transport; IEA:InterPro.
# GO_process	GO:0007018	microtubule-based movement; TAS:Reactome.
# GO_process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
# GO_process	GO:0030100	regulation of endocytosis; TAS:UniProtKB.
# GO_process	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0048013	ephrin receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0048268	clathrin coat assembly; TAS:UniProtKB.
# GO_process	GO:0050690	regulation of defense response to virus by virus; TAS:Reactome.
# GO_process	GO:0060071	Wnt signaling pathway, planar cell polarity pathway; TAS:Reactome.
# GO_process	GO:0072583	clathrin-dependent endocytosis; TAS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# Genevisible	P53680	HS
# HGNC	HGNC:565	AP2S1
# INTERACTION	AP2S1_HUMAN	Q6PD74 AAGAB; NbExp=5; IntAct=EBI-297662, EBI-719906; 
# IntAct	P53680	21
# InterPro	IPR000804	Clathrin_sm-chain_CS
# InterPro	IPR011012	Longin-like_dom
# InterPro	IPR016635	AP_complex_ssu
# InterPro	IPR022775	AP_mu_sigma_su
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Pathway	ko04144	Endocytosis
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04961	Endocrine and other factor-regulated calcium reabsorption
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	600740	phenotype
# MIM	602242	gene
# Organism	AP2S1_HUMAN	Homo sapiens (Human)
# Orphanet	101050	Familial hypocalciuric hypercalcemia type 3
# PANTHER	PTHR11753	PTHR11753
# PIRSF	PIRSF015588	AP_complex_sigma
# PROSITE	PS00989	CLAT_ADAPTOR_S
# Pfam	PF01217	Clat_adaptor_s
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-167590	Nef Mediated CD4 Down-regulation
# Reactome	R-HSA-171052	LDL-mediated lipid transport
# Reactome	R-HSA-177504	Retrograde neurotrophin signalling
# Reactome	R-HSA-182218	Nef Mediated CD8 Down-regulation
# Reactome	R-HSA-2132295	MHC class II antigen presentation
# Reactome	R-HSA-3928665	EPH-ephrin mediated repulsion of cells
# Reactome	R-HSA-416993	Trafficking of GluR2-containing AMPA receptors
# Reactome	R-HSA-437239	Recycling pathway of L1
# Reactome	R-HSA-5099900	WNT5A-dependent internalization of FZD4
# Reactome	R-HSA-5140745	WNT5A-dependent internalization of FZD2, FZD5 and ROR2
# Reactome	R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis
# Reactome	R-HSA-8856828	Clathrin-mediated endocytosis
# Reactome	R-HSA-8866427	VLDLR internalisation and degradation
# RecName	AP2S1_HUMAN	AP-2 complex subunit sigma
# RefSeq	NP_001288005	NM_001301076.1
# RefSeq	NP_001288007	NM_001301078.1
# RefSeq	NP_001288010	NM_001301081.1
# RefSeq	NP_004060	NM_004069.4. [P53680-1]
# RefSeq	NP_067586	NM_021575.3. [P53680-2]
# SIMILARITY	Belongs to the adaptor complexes small subunit family. {ECO	0000305}.
# SUBCELLULAR LOCATION	AP2S1_HUMAN	Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. {ECO 0000250}. 
# SUBUNIT	AP2S1_HUMAN	Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1). 
# SUPFAM	SSF64356	SSF64356
# TopDownProteomics	P53680-1	-. [P53680-1]
# UCSC	uc002pft	human. [P53680-1]
# eggNOG	COG5030	LUCA
# eggNOG	KOG0935	Eukaryota
BLAST	swissprot:AP2S1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AP2S1_HUMAN
BioCyc	ZFISH:ENSG00000042753-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000042753-MONOMER
COXPRESdb	1175	http://coxpresdb.jp/data/gene/1175.shtml
CleanEx	HS_AP2S1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AP2S1
DOI	10.1016/S0378-1119(98)00406-5	http://dx.doi.org/10.1016/S0378-1119(98)00406-5
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1038/ng.2492	http://dx.doi.org/10.1038/ng.2492
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1146/annurev.cellbio.20.010403.104543	http://dx.doi.org/10.1146/annurev.cellbio.20.010403.104543
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1210/jc.2013-2571	http://dx.doi.org/10.1210/jc.2013-2571
DOI	10.1242/jcs.033522	http://dx.doi.org/10.1242/jcs.033522
DOI	10.1247/csf.28.419	http://dx.doi.org/10.1247/csf.28.419
EMBL	AJ010148	http://www.ebi.ac.uk/ena/data/view/AJ010148
EMBL	AJ010149	http://www.ebi.ac.uk/ena/data/view/AJ010149
EMBL	AK312003	http://www.ebi.ac.uk/ena/data/view/AK312003
EMBL	BC006337	http://www.ebi.ac.uk/ena/data/view/BC006337
EMBL	CH471126	http://www.ebi.ac.uk/ena/data/view/CH471126
EMBL	X97074	http://www.ebi.ac.uk/ena/data/view/X97074
Ensembl	ENST00000263270	http://www.ensembl.org/id/ENST00000263270
Ensembl	ENST00000601649	http://www.ensembl.org/id/ENST00000601649
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0030122	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030122
GO_component	GO:0030666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030666
GO_component	GO:0030669	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030669
GO_component	GO:0036020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036020
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0006886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006886
GO_process	GO:0007018	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007018
GO_process	GO:0019886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019886
GO_process	GO:0030100	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030100
GO_process	GO:0042059	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042059
GO_process	GO:0048013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048013
GO_process	GO:0048268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048268
GO_process	GO:0050690	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050690
GO_process	GO:0060071	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060071
GO_process	GO:0072583	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072583
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GeneCards	AP2S1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=AP2S1
GeneID	1175	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1175
GeneTree	ENSGT00530000062839	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062839
HGNC	HGNC:565	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:565
HOGENOM	HOG000185227	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000185227&db=HOGENOM6
HOVERGEN	HBG050517	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050517&db=HOVERGEN
InParanoid	P53680	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P53680
IntAct	P53680	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P53680*
InterPro	IPR000804	http://www.ebi.ac.uk/interpro/entry/IPR000804
InterPro	IPR011012	http://www.ebi.ac.uk/interpro/entry/IPR011012
InterPro	IPR016635	http://www.ebi.ac.uk/interpro/entry/IPR016635
InterPro	IPR022775	http://www.ebi.ac.uk/interpro/entry/IPR022775
Jabion	1175	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1175
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Gene	hsa:1175	http://www.genome.jp/dbget-bin/www_bget?hsa:1175
KEGG_Orthology	KO:K11827	http://www.genome.jp/dbget-bin/www_bget?KO:K11827
KEGG_Pathway	ko04144	http://www.genome.jp/kegg-bin/show_pathway?ko04144
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04961	http://www.genome.jp/kegg-bin/show_pathway?ko04961
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	600740	http://www.ncbi.nlm.nih.gov/omim/600740
MIM	602242	http://www.ncbi.nlm.nih.gov/omim/602242
MINT	MINT-256650	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-256650
Orphanet	101050	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=101050
PANTHER	PTHR11753	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11753
PROSITE	PS00989	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00989
PSORT	swissprot:AP2S1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AP2S1_HUMAN
PSORT-B	swissprot:AP2S1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AP2S1_HUMAN
PSORT2	swissprot:AP2S1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AP2S1_HUMAN
Pfam	PF01217	http://pfam.xfam.org/family/PF01217
PharmGKB	PA24856	http://www.pharmgkb.org/do/serve?objId=PA24856&objCls=Gene
Phobius	swissprot:AP2S1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AP2S1_HUMAN
PhylomeDB	P53680	http://phylomedb.org/?seqid=P53680
ProteinModelPortal	P53680	http://www.proteinmodelportal.org/query/uniprot/P53680
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	14745134	http://www.ncbi.nlm.nih.gov/pubmed/14745134
PubMed	15473838	http://www.ncbi.nlm.nih.gov/pubmed/15473838
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	19033387	http://www.ncbi.nlm.nih.gov/pubmed/19033387
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23222959	http://www.ncbi.nlm.nih.gov/pubmed/23222959
PubMed	24081735	http://www.ncbi.nlm.nih.gov/pubmed/24081735
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	9040778	http://www.ncbi.nlm.nih.gov/pubmed/9040778
PubMed	9767099	http://www.ncbi.nlm.nih.gov/pubmed/9767099
Reactome	R-HSA-167590	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-167590
Reactome	R-HSA-171052	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-171052
Reactome	R-HSA-177504	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-177504
Reactome	R-HSA-182218	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-182218
Reactome	R-HSA-2132295	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2132295
Reactome	R-HSA-3928665	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3928665
Reactome	R-HSA-416993	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-416993
Reactome	R-HSA-437239	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-437239
Reactome	R-HSA-5099900	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5099900
Reactome	R-HSA-5140745	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5140745
Reactome	R-HSA-8856825	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8856825
Reactome	R-HSA-8856828	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8856828
Reactome	R-HSA-8866427	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8866427
RefSeq	NP_001288005	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001288005
RefSeq	NP_001288007	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001288007
RefSeq	NP_001288010	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001288010
RefSeq	NP_004060	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004060
RefSeq	NP_067586	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_067586
SMR	P53680	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P53680
STRING	9606.ENSP00000263270	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000263270&targetmode=cogs
SUPFAM	SSF64356	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF64356
UCSC	uc002pft	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002pft&org=rat
UniGene	Hs.119591	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.119591
UniProtKB	AP2S1_HUMAN	http://www.uniprot.org/uniprot/AP2S1_HUMAN
UniProtKB-AC	P53680	http://www.uniprot.org/uniprot/P53680
charge	swissprot:AP2S1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AP2S1_HUMAN
eggNOG	COG5030	http://eggnogapi.embl.de/nog_data/html/tree/COG5030
eggNOG	KOG0935	http://eggnogapi.embl.de/nog_data/html/tree/KOG0935
epestfind	swissprot:AP2S1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AP2S1_HUMAN
garnier	swissprot:AP2S1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AP2S1_HUMAN
helixturnhelix	swissprot:AP2S1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AP2S1_HUMAN
hmoment	swissprot:AP2S1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AP2S1_HUMAN
iep	swissprot:AP2S1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AP2S1_HUMAN
inforesidue	swissprot:AP2S1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AP2S1_HUMAN
neXtProt	NX_P53680	http://www.nextprot.org/db/entry/NX_P53680
octanol	swissprot:AP2S1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AP2S1_HUMAN
pepcoil	swissprot:AP2S1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AP2S1_HUMAN
pepdigest	swissprot:AP2S1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AP2S1_HUMAN
pepinfo	swissprot:AP2S1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AP2S1_HUMAN
pepnet	swissprot:AP2S1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AP2S1_HUMAN
pepstats	swissprot:AP2S1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AP2S1_HUMAN
pepwheel	swissprot:AP2S1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AP2S1_HUMAN
pepwindow	swissprot:AP2S1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AP2S1_HUMAN
sigcleave	swissprot:AP2S1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AP2S1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	IPO11_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UI26-1; Sequence=Displayed; Name=2; IsoId=Q9UI26-2; Sequence=VSP_041420; 
# AltName	IPO11_HUMAN	Ran-binding protein 11
# BioGrid	119368	70
# CCDS	CCDS34167	-. [Q9UI26-1]
# CCDS	CCDS47217	-. [Q9UI26-2]
# ChiTaRS	IPO11	human
# Ensembl	ENST00000325324	ENSP00000316651; ENSG00000086200. [Q9UI26-1]
# Ensembl	ENST00000409296	ENSP00000386992; ENSG00000086200. [Q9UI26-2]
# ExpressionAtlas	Q9UI26	baseline and differential
# FUNCTION	IPO11_HUMAN	Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity). {ECO 0000250, ECO 0000269|PubMed 11032817}. 
# GO_component	GO:0005635	nuclear envelope; IBA:GO_Central.
# GO_component	GO:0005829	cytosol; IBA:GO_Central.
# GO_function	GO:0008565	protein transporter activity; IBA:GO_Central.
# GO_process	GO:0006610	ribosomal protein import into nucleus; IEA:Ensembl.
# GO_process	GO:0042991	transcription factor import into nucleus; IBA:GO_Central.
# GOslim_component	GO:0005635	nuclear envelope
# GOslim_component	GO:0005829	cytosol
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# Gene3D	1.25.10.10	-; 2.
# Genevisible	Q9UI26	HS
# HGNC	HGNC:20628	IPO11
# INTERACTION	IPO11_HUMAN	Q6P1W5 C1orf94; NbExp=3; IntAct=EBI-748752, EBI-946029; Q14240 EIF4A2; NbExp=3; IntAct=EBI-748752, EBI-73473; 
# IntAct	Q9UI26	9
# InterPro	IPR001494	Importin-beta_N
# InterPro	IPR011989	ARM-like
# InterPro	IPR016024	ARM-type_fold
# MIM	610889	gene
# Organism	IPO11_HUMAN	Homo sapiens (Human)
# PIR	T47185	T47185
# PROSITE	PS50166	IMPORTIN_B_NT
# Pfam	PF03810	IBN_N
# Proteomes	UP000005640	Chromosome 5
# RecName	IPO11_HUMAN	Importin-11
# RefSeq	NP_001128251	NM_001134779.1. [Q9UI26-2]
# RefSeq	NP_057422	NM_016338.4. [Q9UI26-1]
# SIMILARITY	Belongs to the importin beta family. {ECO	0000305}. 
# SIMILARITY	Contains 1 importin N-terminal domain. {ECO:0000255|PROSITE-ProRule	PRU00115}.
# SIMILARITY	Contains 15 HEAT repeats. {ECO	0000305}. 
# SMART	SM00913	IBN_N
# SUBCELLULAR LOCATION	IPO11_HUMAN	Cytoplasm {ECO 0000269|PubMed 11032817}. Nucleus {ECO 0000269|PubMed 11032817}. 
# SUBUNIT	Interacts with UBE2E3 and RPL12. {ECO:0000269|PubMed	11032817}. 
# SUPFAM	SSF48371	SSF48371
# TCDB	1.I.1.1	the nuclear pore complex (npc) family
# UCSC	uc003jtc	human. [Q9UI26-1]
# eggNOG	COG5657	LUCA
# eggNOG	KOG1993	Eukaryota
BLAST	swissprot:IPO11_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:IPO11_HUMAN
COXPRESdb	51194	http://coxpresdb.jp/data/gene/51194.shtml
CleanEx	HS_IPO11	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_IPO11
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/emboj/19.20.5502	http://dx.doi.org/10.1093/emboj/19.20.5502
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AC008859	http://www.ebi.ac.uk/ena/data/view/AC008859
EMBL	AF111109	http://www.ebi.ac.uk/ena/data/view/AF111109
EMBL	AK001696	http://www.ebi.ac.uk/ena/data/view/AK001696
EMBL	AK302781	http://www.ebi.ac.uk/ena/data/view/AK302781
EMBL	AL162083	http://www.ebi.ac.uk/ena/data/view/AL162083
EMBL	BC031694	http://www.ebi.ac.uk/ena/data/view/BC031694
EMBL	BC033776	http://www.ebi.ac.uk/ena/data/view/BC033776
EMBL	CH471137	http://www.ebi.ac.uk/ena/data/view/CH471137
EMBL	CH471137	http://www.ebi.ac.uk/ena/data/view/CH471137
Ensembl	ENST00000325324	http://www.ensembl.org/id/ENST00000325324
Ensembl	ENST00000409296	http://www.ensembl.org/id/ENST00000409296
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0006610	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006610
GO_process	GO:0042991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042991
GOslim_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
GeneCards	IPO11	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=IPO11
GeneID	51194	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51194
GeneTree	ENSGT00390000014071	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000014071
HGNC	HGNC:20628	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20628
HOGENOM	HOG000008140	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000008140&db=HOGENOM6
HOVERGEN	HBG061387	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG061387&db=HOVERGEN
HPA	HPA067097	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA067097
InParanoid	Q9UI26	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UI26
IntAct	Q9UI26	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9UI26*
InterPro	IPR001494	http://www.ebi.ac.uk/interpro/entry/IPR001494
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
Jabion	51194	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=51194
KEGG_Gene	hsa:51194	http://www.genome.jp/dbget-bin/www_bget?hsa:51194
MIM	610889	http://www.ncbi.nlm.nih.gov/omim/610889
MINT	MINT-1460740	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1460740
OMA	LLLIRAC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LLLIRAC
OrthoDB	EOG091G01EL	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01EL
PROSITE	PS50166	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50166
PSORT	swissprot:IPO11_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:IPO11_HUMAN
PSORT-B	swissprot:IPO11_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:IPO11_HUMAN
PSORT2	swissprot:IPO11_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:IPO11_HUMAN
Pfam	PF03810	http://pfam.xfam.org/family/PF03810
PharmGKB	PA134936197	http://www.pharmgkb.org/do/serve?objId=PA134936197&objCls=Gene
Phobius	swissprot:IPO11_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:IPO11_HUMAN
PhylomeDB	Q9UI26	http://phylomedb.org/?seqid=Q9UI26
ProteinModelPortal	Q9UI26	http://www.proteinmodelportal.org/query/uniprot/Q9UI26
PubMed	11032817	http://www.ncbi.nlm.nih.gov/pubmed/11032817
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
RefSeq	NP_001128251	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001128251
RefSeq	NP_057422	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_057422
SMART	SM00913	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00913
STRING	9606.ENSP00000386992	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000386992&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
TCDB	1.I.1.1	http://www.tcdb.org/search/result.php?tc=1.I.1.1
UCSC	uc003jtc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003jtc&org=rat
UniGene	Hs.482269	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.482269
UniProtKB	IPO11_HUMAN	http://www.uniprot.org/uniprot/IPO11_HUMAN
UniProtKB-AC	Q9UI26	http://www.uniprot.org/uniprot/Q9UI26
charge	swissprot:IPO11_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:IPO11_HUMAN
eggNOG	COG5657	http://eggnogapi.embl.de/nog_data/html/tree/COG5657
eggNOG	KOG1993	http://eggnogapi.embl.de/nog_data/html/tree/KOG1993
epestfind	swissprot:IPO11_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:IPO11_HUMAN
garnier	swissprot:IPO11_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:IPO11_HUMAN
helixturnhelix	swissprot:IPO11_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:IPO11_HUMAN
hmoment	swissprot:IPO11_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:IPO11_HUMAN
iep	swissprot:IPO11_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:IPO11_HUMAN
inforesidue	swissprot:IPO11_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:IPO11_HUMAN
neXtProt	NX_Q9UI26	http://www.nextprot.org/db/entry/NX_Q9UI26
octanol	swissprot:IPO11_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:IPO11_HUMAN
pepcoil	swissprot:IPO11_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:IPO11_HUMAN
pepdigest	swissprot:IPO11_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:IPO11_HUMAN
pepinfo	swissprot:IPO11_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:IPO11_HUMAN
pepnet	swissprot:IPO11_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:IPO11_HUMAN
pepstats	swissprot:IPO11_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:IPO11_HUMAN
pepwheel	swissprot:IPO11_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:IPO11_HUMAN
pepwindow	swissprot:IPO11_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:IPO11_HUMAN
sigcleave	swissprot:IPO11_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:IPO11_HUMAN
## Database	ID	URL or Descriptions
# AltName	SC5A6_HUMAN	Solute carrier family 5 member 6
# BioGrid	114403	4
# ChiTaRS	SLC5A6	human
# DrugBank	DB00121	Biotin
# DrugBank	DB00166	Lipoic Acid
# DrugBank	DB08872	gabapentin enacarbil
# Ensembl	ENST00000310574	ENSP00000310208; ENSG00000138074
# Ensembl	ENST00000408041	ENSP00000384853; ENSG00000138074
# ExpressionAtlas	Q9Y289	baseline and differential
# FUNCTION	SC5A6_HUMAN	Transports pantothenate, biotin and lipoate in the presence of sodium. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0012506	vesicle membrane; IEA:Ensembl.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0031526	brush border membrane; IEA:Ensembl.
# GO_function	GO:0008523	sodium-dependent multivitamin transmembrane transporter activity; TAS:ProtInc.
# GO_process	GO:0006768	biotin metabolic process; TAS:Reactome.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0015878	biotin transport; IBA:GO_Central.
# GO_process	GO:0015887	pantothenate transmembrane transport; IBA:GO_Central.
# GO_process	GO:0015939	pantothenate metabolic process; TAS:Reactome.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006790	sulfur compound metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0051186	cofactor metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9Y289	HS
# HGNC	HGNC:11041	SLC5A6
# IntAct	Q9Y289	2
# InterPro	IPR001734	Na/solute_symporter
# InterPro	IPR018212	Na/solute_symporter_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04977	Vitamin digestion and absorption
# MIM	604024	gene
# Organism	SC5A6_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11819	PTHR11819; 2
# PROSITE	PS00456	NA_SOLUT_SYMP_1
# PROSITE	PS50283	NA_SOLUT_SYMP_3
# Pfam	PF00474	SSF
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-196780	Biotin transport and metabolism
# Reactome	R-HSA-199220	Vitamin B5 (pantothenate) metabolism
# Reactome	R-HSA-425397	Transport of vitamins, nucleosides, and related molecules
# RecName	SC5A6_HUMAN	Sodium-dependent multivitamin transporter
# RefSeq	NP_066918	NM_021095.2
# RefSeq	XP_006712191	XM_006712128.1
# RefSeq	XP_006712192	XM_006712129.1
# RefSeq	XP_006712193	XM_006712130.1
# SIMILARITY	Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	SC5A6_HUMAN	Membrane; Multi-pass membrane protein. 
# TCDB	2.A.21.5:the solute	sodium symporter (sss) family
# TIGRFAMs	TIGR00813	sss
# UCSC	uc002rjd	human
# eggNOG	COG0591	LUCA
# eggNOG	KOG2349	Eukaryota
BLAST	swissprot:SC5A6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SC5A6_HUMAN
BioCyc	ZFISH:ENSG00000138074-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000138074-MONOMER
COXPRESdb	8884	http://coxpresdb.jp/data/gene/8884.shtml
CleanEx	HS_SLC5A6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC5A6
DOI	10.1006/abbi.1999.1213	http://dx.doi.org/10.1006/abbi.1999.1213
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.274.21.14875	http://dx.doi.org/10.1074/jbc.274.21.14875
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00121	http://www.drugbank.ca/drugs/DB00121
DrugBank	DB00166	http://www.drugbank.ca/drugs/DB00166
DrugBank	DB08872	http://www.drugbank.ca/drugs/DB08872
EMBL	AC013403	http://www.ebi.ac.uk/ena/data/view/AC013403
EMBL	AF069307	http://www.ebi.ac.uk/ena/data/view/AF069307
EMBL	AF081571	http://www.ebi.ac.uk/ena/data/view/AF081571
EMBL	AF116241	http://www.ebi.ac.uk/ena/data/view/AF116241
EMBL	AK314545	http://www.ebi.ac.uk/ena/data/view/AK314545
EMBL	BC012806	http://www.ebi.ac.uk/ena/data/view/BC012806
EMBL	BC015631	http://www.ebi.ac.uk/ena/data/view/BC015631
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
Ensembl	ENST00000310574	http://www.ensembl.org/id/ENST00000310574
Ensembl	ENST00000408041	http://www.ensembl.org/id/ENST00000408041
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0012506	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0012506
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0031526	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031526
GO_function	GO:0008523	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008523
GO_process	GO:0006768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006768
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0015878	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015878
GO_process	GO:0015887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015887
GO_process	GO:0015939	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015939
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0051186	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC5A6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC5A6
GeneID	8884	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8884
GeneTree	ENSGT00760000118955	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118955
HGNC	HGNC:11041	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11041
HOGENOM	HOG000261662	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261662&db=HOGENOM6
HOVERGEN	HBG057280	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG057280&db=HOVERGEN
HPA	HPA036958	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA036958
InParanoid	Q9Y289	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y289
IntAct	Q9Y289	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9Y289*
InterPro	IPR001734	http://www.ebi.ac.uk/interpro/entry/IPR001734
InterPro	IPR018212	http://www.ebi.ac.uk/interpro/entry/IPR018212
Jabion	8884	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=8884
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:8884	http://www.genome.jp/dbget-bin/www_bget?hsa:8884
KEGG_Orthology	KO:K14386	http://www.genome.jp/dbget-bin/www_bget?KO:K14386
KEGG_Pathway	ko04977	http://www.genome.jp/kegg-bin/show_pathway?ko04977
MIM	604024	http://www.ncbi.nlm.nih.gov/omim/604024
MINT	MINT-5005745	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5005745
OMA	CILQETS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CILQETS
OrthoDB	EOG091G07OC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07OC
PANTHER	PTHR11819	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11819
PROSITE	PS00456	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00456
PROSITE	PS50283	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50283
PSORT	swissprot:SC5A6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SC5A6_HUMAN
PSORT-B	swissprot:SC5A6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SC5A6_HUMAN
PSORT2	swissprot:SC5A6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SC5A6_HUMAN
Pfam	PF00474	http://pfam.xfam.org/family/PF00474
PharmGKB	PA379	http://www.pharmgkb.org/do/serve?objId=PA379&objCls=Gene
Phobius	swissprot:SC5A6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SC5A6_HUMAN
PhylomeDB	Q9Y289	http://phylomedb.org/?seqid=Q9Y289
ProteinModelPortal	Q9Y289	http://www.proteinmodelportal.org/query/uniprot/Q9Y289
PubMed	10329687	http://www.ncbi.nlm.nih.gov/pubmed/10329687
PubMed	10334869	http://www.ncbi.nlm.nih.gov/pubmed/10334869
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
Reactome	R-HSA-196780	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-196780
Reactome	R-HSA-199220	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-199220
Reactome	R-HSA-425397	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425397
RefSeq	NP_066918	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_066918
RefSeq	XP_006712191	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006712191
RefSeq	XP_006712192	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006712192
RefSeq	XP_006712193	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006712193
STRING	9606.ENSP00000310208	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000310208&targetmode=cogs
TCDB	2.A.21.5	http://www.tcdb.org/search/result.php?tc=2.A.21.5
TIGRFAMs	TIGR00813	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00813
UCSC	uc002rjd	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002rjd&org=rat
UniGene	Hs.435735	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.435735
UniProtKB	SC5A6_HUMAN	http://www.uniprot.org/uniprot/SC5A6_HUMAN
UniProtKB-AC	Q9Y289	http://www.uniprot.org/uniprot/Q9Y289
charge	swissprot:SC5A6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SC5A6_HUMAN
eggNOG	COG0591	http://eggnogapi.embl.de/nog_data/html/tree/COG0591
eggNOG	KOG2349	http://eggnogapi.embl.de/nog_data/html/tree/KOG2349
epestfind	swissprot:SC5A6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SC5A6_HUMAN
garnier	swissprot:SC5A6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SC5A6_HUMAN
helixturnhelix	swissprot:SC5A6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SC5A6_HUMAN
hmoment	swissprot:SC5A6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SC5A6_HUMAN
iep	swissprot:SC5A6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SC5A6_HUMAN
inforesidue	swissprot:SC5A6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SC5A6_HUMAN
neXtProt	NX_Q9Y289	http://www.nextprot.org/db/entry/NX_Q9Y289
octanol	swissprot:SC5A6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SC5A6_HUMAN
pepcoil	swissprot:SC5A6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SC5A6_HUMAN
pepdigest	swissprot:SC5A6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SC5A6_HUMAN
pepinfo	swissprot:SC5A6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SC5A6_HUMAN
pepnet	swissprot:SC5A6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SC5A6_HUMAN
pepstats	swissprot:SC5A6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SC5A6_HUMAN
pepwheel	swissprot:SC5A6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SC5A6_HUMAN
pepwindow	swissprot:SC5A6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SC5A6_HUMAN
sigcleave	swissprot:SC5A6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SC5A6_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TAP2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q03519-1; Sequence=Displayed; Name=2; IsoId=Q03519-2; Sequence=VSP_038904; 
# AltName	TAP2_HUMAN	ATP-binding cassette sub-family B member 3
# AltName	TAP2_HUMAN	Peptide supply factor 2
# AltName	TAP2_HUMAN	Peptide transporter PSF2
# AltName	TAP2_HUMAN	Peptide transporter TAP2
# AltName	TAP2_HUMAN	Peptide transporter involved in antigen processing 2
# AltName	TAP2_HUMAN	Really interesting new gene 11 protein
# BRENDA	3.6.3.43	2681
# BioGrid	112754	28
# CCDS	CCDS4755	-. [Q03519-2]
# CCDS	CCDS78129	-. [Q03519-1]
# DISEASE	TAP2_HUMAN	Bare lymphocyte syndrome 1 (BLS1) [MIM 604571]  A HLA class I deficiency. Contrary to bare lymphocyte syndromes type 2 and type 3, which are characterized by early-onset severe combined immunodeficiency, class I antigen deficiencies are not accompanied by particular pathologic manifestations during the first years of life. Systemic infections have not been described. Chronic bacterial infections, often beginning in the first decade of life, are restricted to the respiratory tract. {ECO 0000269|PubMed 7517574}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	TAP2_HUMAN	The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2. 
# Ensembl	ENST00000374897	ENSP00000364032; ENSG00000204267. [Q03519-1]
# Ensembl	ENST00000374899	ENSP00000364034; ENSG00000204267. [Q03519-2]
# Ensembl	ENST00000383118	ENSP00000372599; ENSG00000206235. [Q03519-1]
# Ensembl	ENST00000383119	ENSP00000372600; ENSG00000206235. [Q03519-2]
# Ensembl	ENST00000383239	ENSP00000372726; ENSG00000206299. [Q03519-1]
# Ensembl	ENST00000383240	ENSP00000372727; ENSG00000206299. [Q03519-2]
# Ensembl	ENST00000414145	ENSP00000401377; ENSG00000228582. [Q03519-2]
# Ensembl	ENST00000419142	ENSP00000390013; ENSG00000237599
# Ensembl	ENST00000426977	ENSP00000387553; ENSG00000232326. [Q03519-2]
# Ensembl	ENST00000439425	ENSP00000396156; ENSG00000225967. [Q03519-2]
# Ensembl	ENST00000443713	ENSP00000394101; ENSG00000228582. [Q03519-1]
# Ensembl	ENST00000451907	ENSP00000392172; ENSG00000223481. [Q03519-2]
# ExpressionAtlas	Q03519	baseline and differential
# FUNCTION	TAP2_HUMAN	Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. 
# GO_component	GO:0005789	endoplasmic reticulum membrane; TAS:Reactome.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IDA:UniProtKB.
# GO_component	GO:0030176	integral component of endoplasmic reticulum membrane; IDA:UniProtKB.
# GO_component	GO:0042825	TAP complex; IDA:UniProtKB.
# GO_component	GO:0043657	host cell; IEA:GOC.
# GO_function	GO:0005215	transporter activity; IDA:MGI.
# GO_function	GO:0005524	ATP binding; IDA:UniProtKB.
# GO_function	GO:0015197	peptide transporter activity; IEA:InterPro.
# GO_function	GO:0015433	peptide antigen-transporting ATPase activity; IMP:UniProtKB.
# GO_function	GO:0023029	MHC class Ib protein binding; IPI:UniProtKB.
# GO_function	GO:0046978	TAP1 binding; IPI:UniProtKB.
# GO_function	GO:0046980	tapasin binding; ISS:UniProtKB.
# GO_process	GO:0002250	adaptive immune response; IEA:UniProtKB-KW.
# GO_process	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome.
# GO_process	GO:0002481	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; IBA:GO_Central.
# GO_process	GO:0002485	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; IBA:GO_Central.
# GO_process	GO:0002489	antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; IMP:UniProtKB.
# GO_process	GO:0002591	positive regulation of antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central.
# GO_process	GO:0019060	intracellular transport of viral protein in host cell; IMP:UniProtKB.
# GO_process	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I; IDA:UniProtKB.
# GO_process	GO:0046967	cytosol to ER transport; IMP:UniProtKB.
# GO_process	GO:0046968	peptide antigen transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# Gene3D	3.40.50.300	-; 1.
# Genevisible	Q03519	HS
# HGNC	HGNC:44	TAP2
# INDUCTION	TAP2_HUMAN	By IFNG/IFN-gamma. 
# INTERACTION	TAP2_HUMAN	P0C739 BNLF2a (xeno); NbExp=6; IntAct=EBI-780781, EBI-9346744; Q77CE4 gN (xeno); NbExp=2; IntAct=EBI-780781, EBI-11303846; Q03518 TAP1; NbExp=15; IntAct=EBI-780781, EBI-747259; O15533 TAPBP; NbExp=8; IntAct=EBI-780781, EBI-874801; 
# IntAct	Q03519	22
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR005293	Tap2/ABCB3
# InterPro	IPR011527	ABC1_TM_dom
# InterPro	IPR013305	ABC_Tap-like
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Disease	H00093	[Primary immunodeficiency] CD8 deficiency
# KEGG_Disease	H00984	[Inherited metabolic disease; Immune system disease] Bare lymphocyte syndrome (BLS) type1
# KEGG_Pathway	ko02010	ABC transporters
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko04612	Antigen processing and presentation
# KEGG_Pathway	ko05168	Herpes simplex infection
# KEGG_Pathway	ko05340	Primary immunodeficiency
# MIM	170261	gene
# MIM	604571	phenotype
# Organism	TAP2_HUMAN	Homo sapiens (Human)
# Orphanet	34592	Immunodeficiency by defective expression of HLA class 1
# PIR	B41538	B41538
# POLYMORPHISM	TAP2_HUMAN	4 common alleles are officially recognized  TAP2*01 01 (TAP2A or PSF2A or RING11A), TAP2*01 02 (TAP2E), TAP2*01 03 (TAP2F), and TAP2*02 01 (TAP2B or PSF2B or RING11B). Other relatively common alleles have been identified  TAP2*01D, TAP2*01E, TAP2*01F, TAP2*01G, TAP2*01H, TAP2*02B, TAP2*02C (TAP2*02 02), TAP2*02D, TAP2*02E, TAP2*02F, TAP2*03A and TAP2*04A. The sequence shown is that of TAP2*01 01. {ECO 0000269|PubMed 11294565, ECO 0000269|PubMed 1453454, ECO 0000269|PubMed 1741401, ECO 0000269|PubMed 1946428, ECO 0000269|PubMed 8428770, ECO 0000269|PubMed 8568858}. 
# POLYMORPHISM	The allele TAP2*Bky2 is commonly found only in the Japanese population. It may be associated with susceptibility to Sjoegren syndrome, an autoimmune disorder characterized by abnormal dryness of the conjunctiva, cornea and mouth due to exocrine glands dysfunction. {ECO:0000269|PubMed	9324024}. 
# PRINTS	PR01897	TAP2PROTEIN
# PROSITE	PS00211	ABC_TRANSPORTER_1
# PROSITE	PS50893	ABC_TRANSPORTER_2
# PROSITE	PS50929	ABC_TM1F
# Pfam	PF00005	ABC_tran
# Pfam	PF00664	ABC_membrane
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-1236974	ER-Phagosome pathway
# Reactome	R-HSA-983170:Antigen Presentation	 Folding, assembly and peptide loading of class I MHC
# RecName	TAP2_HUMAN	Antigen peptide transporter 2
# RefSeq	NP_000535	NM_000544.3
# RefSeq	NP_001276972	NM_001290043.1. [Q03519-1]
# RefSeq	NP_061313	NM_018833.2. [Q03519-2]
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule	PRU00441}. 
# SIMILARITY	Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA
# SUBCELLULAR LOCATION	TAP2_HUMAN	Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=The transmembrane segments seem to form a pore in the membrane. 
# SUBUNIT	TAP2_HUMAN	Heterodimer of TAP1 and TAP2. Interacts with Epstein-Barr virus BLNF2a. Interacts with herpes simplex virus ICP47 (PubMed 7760936). {ECO 0000269|PubMed 19201886, ECO 0000269|PubMed 7760936}. 
# SUPFAM	SSF52540	SSF52540
# SUPFAM	SSF90123	SSF90123
# TCDB	3.A.1.209	the atp-binding cassette (abc) superfamily
# TIGRFAMs	TIGR00958	3a01208
# TopDownProteomics	Q03519-2	-. [Q03519-2]
# UCSC	uc063yci	human. [Q03519-1]
# WEB RESOURCE	TAP2_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=Q03519";
# WEB RESOURCE	TAP2_HUMAN	Name=TAP2base; Note=TAP2 mutation db; URL="http //structure.bmc.lu.se/idbase/TAP2base/"; 
# eggNOG	COG1132	LUCA
# eggNOG	KOG0058	Eukaryota
BLAST	swissprot:TAP2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TAP2_HUMAN
BioCyc	ZFISH:ENSG00000080469-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000080469-MONOMER
COXPRESdb	6891	http://coxpresdb.jp/data/gene/6891.shtml
CleanEx	HS_TAP2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TAP2
DIP	DIP-322N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-322N
DOI	10.1002/art.1780400919	http://dx.doi.org/10.1002/art.1780400919
DOI	10.1006/jmbi.1996.0001	http://dx.doi.org/10.1006/jmbi.1996.0001
DOI	10.1007/BF00216802	http://dx.doi.org/10.1007/BF00216802
DOI	10.1016/0022-2836(92)90832-5	http://dx.doi.org/10.1016/0022-2836(92)90832-5
DOI	10.1016/S1074-7613(00)80349-0	http://dx.doi.org/10.1016/S1074-7613(00)80349-0
DOI	10.1038/375415a0	http://dx.doi.org/10.1038/375415a0
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/sj.gene.6363731	http://dx.doi.org/10.1038/sj.gene.6363731
DOI	10.1073/pnas.88.22.10094	http://dx.doi.org/10.1073/pnas.88.22.10094
DOI	10.1073/pnas.89.4.1463	http://dx.doi.org/10.1073/pnas.89.4.1463
DOI	10.1073/pnas.89.9.3932	http://dx.doi.org/10.1073/pnas.89.9.3932
DOI	10.1093/emboj/20.3.387	http://dx.doi.org/10.1093/emboj/20.3.387
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1399-0039.1995.tb02431.x	http://dx.doi.org/10.1111/j.1399-0039.1995.tb02431.x
DOI	10.1111/j.1399-0039.1998.tb02992.x	http://dx.doi.org/10.1111/j.1399-0039.1998.tb02992.x
DOI	10.1126/science.7517574	http://dx.doi.org/10.1126/science.7517574
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.4049/jimmunol.0803218	http://dx.doi.org/10.4049/jimmunol.0803218
EMBL	AB073779	http://www.ebi.ac.uk/ena/data/view/AB073779
EMBL	AF105151	http://www.ebi.ac.uk/ena/data/view/AF105151
EMBL	AH007554	http://www.ebi.ac.uk/ena/data/view/AH007554
EMBL	AK222823	http://www.ebi.ac.uk/ena/data/view/AK222823
EMBL	AK223300	http://www.ebi.ac.uk/ena/data/view/AK223300
EMBL	BC002751	http://www.ebi.ac.uk/ena/data/view/BC002751
EMBL	BX296564	http://www.ebi.ac.uk/ena/data/view/BX296564
EMBL	BX682530	http://www.ebi.ac.uk/ena/data/view/BX682530
EMBL	CR753889	http://www.ebi.ac.uk/ena/data/view/CR753889
EMBL	CR762476	http://www.ebi.ac.uk/ena/data/view/CR762476
EMBL	CR788227	http://www.ebi.ac.uk/ena/data/view/CR788227
EMBL	CT009502	http://www.ebi.ac.uk/ena/data/view/CT009502
EMBL	L09191	http://www.ebi.ac.uk/ena/data/view/L09191
EMBL	L10287	http://www.ebi.ac.uk/ena/data/view/L10287
EMBL	M74447	http://www.ebi.ac.uk/ena/data/view/M74447
EMBL	M84748	http://www.ebi.ac.uk/ena/data/view/M84748
EMBL	U07844	http://www.ebi.ac.uk/ena/data/view/U07844
EMBL	X66401	http://www.ebi.ac.uk/ena/data/view/X66401
EMBL	X87344	http://www.ebi.ac.uk/ena/data/view/X87344
EMBL	Z22935	http://www.ebi.ac.uk/ena/data/view/Z22935
EMBL	Z22936	http://www.ebi.ac.uk/ena/data/view/Z22936
Ensembl	ENST00000374897	http://www.ensembl.org/id/ENST00000374897
Ensembl	ENST00000374899	http://www.ensembl.org/id/ENST00000374899
Ensembl	ENST00000383118	http://www.ensembl.org/id/ENST00000383118
Ensembl	ENST00000383119	http://www.ensembl.org/id/ENST00000383119
Ensembl	ENST00000383239	http://www.ensembl.org/id/ENST00000383239
Ensembl	ENST00000383240	http://www.ensembl.org/id/ENST00000383240
Ensembl	ENST00000414145	http://www.ensembl.org/id/ENST00000414145
Ensembl	ENST00000419142	http://www.ensembl.org/id/ENST00000419142
Ensembl	ENST00000426977	http://www.ensembl.org/id/ENST00000426977
Ensembl	ENST00000439425	http://www.ensembl.org/id/ENST00000439425
Ensembl	ENST00000443713	http://www.ensembl.org/id/ENST00000443713
Ensembl	ENST00000451907	http://www.ensembl.org/id/ENST00000451907
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030176	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030176
GO_component	GO:0042825	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042825
GO_component	GO:0043657	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043657
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0015197	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015197
GO_function	GO:0015433	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015433
GO_function	GO:0023029	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0023029
GO_function	GO:0046978	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046978
GO_function	GO:0046980	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046980
GO_process	GO:0002250	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002250
GO_process	GO:0002474	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002474
GO_process	GO:0002481	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002481
GO_process	GO:0002485	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002485
GO_process	GO:0002489	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002489
GO_process	GO:0002591	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002591
GO_process	GO:0019060	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019060
GO_process	GO:0019885	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019885
GO_process	GO:0046967	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046967
GO_process	GO:0046968	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046968
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	TAP2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TAP2
GeneID	6891	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6891
GeneTree	ENSGT00550000074497	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074497
H-InvDB	HIX0005757	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0005757
H-InvDB	HIX0166631	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0166631
H-InvDB	HIX0166883	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0166883
H-InvDB	HIX0167147	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0167147
HGNC	HGNC:44	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:44
HOVERGEN	HBG008358	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG008358&db=HOVERGEN
HPA	HPA001312	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA001312
InParanoid	Q03519	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q03519
IntAct	Q03519	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q03519*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR005293	http://www.ebi.ac.uk/interpro/entry/IPR005293
InterPro	IPR011527	http://www.ebi.ac.uk/interpro/entry/IPR011527
InterPro	IPR013305	http://www.ebi.ac.uk/interpro/entry/IPR013305
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	6891	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6891
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Disease	H00093	http://www.genome.jp/dbget-bin/www_bget?H00093
KEGG_Disease	H00984	http://www.genome.jp/dbget-bin/www_bget?H00984
KEGG_Gene	hsa:6891	http://www.genome.jp/dbget-bin/www_bget?hsa:6891
KEGG_Orthology	KO:K05654	http://www.genome.jp/dbget-bin/www_bget?KO:K05654
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko04612	http://www.genome.jp/kegg-bin/show_pathway?ko04612
KEGG_Pathway	ko05168	http://www.genome.jp/kegg-bin/show_pathway?ko05168
KEGG_Pathway	ko05340	http://www.genome.jp/kegg-bin/show_pathway?ko05340
MIM	170261	http://www.ncbi.nlm.nih.gov/omim/170261
MIM	604571	http://www.ncbi.nlm.nih.gov/omim/604571
MINT	MINT-2838244	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-2838244
Orphanet	34592	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=34592
PRINTS	PR01897	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01897
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PROSITE	PS50929	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929
PSORT	swissprot:TAP2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TAP2_HUMAN
PSORT-B	swissprot:TAP2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TAP2_HUMAN
PSORT2	swissprot:TAP2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TAP2_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF00664	http://pfam.xfam.org/family/PF00664
PharmGKB	PA35022	http://www.pharmgkb.org/do/serve?objId=PA35022&objCls=Gene
Phobius	swissprot:TAP2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TAP2_HUMAN
PhylomeDB	Q03519	http://phylomedb.org/?seqid=Q03519
ProteinModelPortal	Q03519	http://www.proteinmodelportal.org/query/uniprot/Q03519
PubMed	10227971	http://www.ncbi.nlm.nih.gov/pubmed/10227971
PubMed	11157746	http://www.ncbi.nlm.nih.gov/pubmed/11157746
PubMed	11294565	http://www.ncbi.nlm.nih.gov/pubmed/11294565
PubMed	1453454	http://www.ncbi.nlm.nih.gov/pubmed/1453454
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	1570316	http://www.ncbi.nlm.nih.gov/pubmed/1570316
PubMed	1741401	http://www.ncbi.nlm.nih.gov/pubmed/1741401
PubMed	19201886	http://www.ncbi.nlm.nih.gov/pubmed/19201886
PubMed	1946428	http://www.ncbi.nlm.nih.gov/pubmed/1946428
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	7517574	http://www.ncbi.nlm.nih.gov/pubmed/7517574
PubMed	7760936	http://www.ncbi.nlm.nih.gov/pubmed/7760936
PubMed	7792761	http://www.ncbi.nlm.nih.gov/pubmed/7792761
PubMed	8162639	http://www.ncbi.nlm.nih.gov/pubmed/8162639
PubMed	8428770	http://www.ncbi.nlm.nih.gov/pubmed/8428770
PubMed	8568858	http://www.ncbi.nlm.nih.gov/pubmed/8568858
PubMed	8670825	http://www.ncbi.nlm.nih.gov/pubmed/8670825
PubMed	8955196	http://www.ncbi.nlm.nih.gov/pubmed/8955196
PubMed	9175839	http://www.ncbi.nlm.nih.gov/pubmed/9175839
PubMed	9324024	http://www.ncbi.nlm.nih.gov/pubmed/9324024
PubMed	9672156	http://www.ncbi.nlm.nih.gov/pubmed/9672156
PubMed	9916708	http://www.ncbi.nlm.nih.gov/pubmed/9916708
Reactome	R-HSA-1236974	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1236974
Reactome	R-HSA-983170	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983170
RefSeq	NP_000535	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000535
RefSeq	NP_001276972	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001276972
RefSeq	NP_061313	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061313
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	Q03519	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q03519
STRING	9606.ENSP00000364034	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000364034&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
SUPFAM	SSF90123	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123
TCDB	3.A.1.209	http://www.tcdb.org/search/result.php?tc=3.A.1.209
TIGRFAMs	TIGR00958	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00958
UCSC	uc063yci	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc063yci&org=rat
UniGene	Hs.502	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.502
UniProtKB	TAP2_HUMAN	http://www.uniprot.org/uniprot/TAP2_HUMAN
UniProtKB-AC	Q03519	http://www.uniprot.org/uniprot/Q03519
charge	swissprot:TAP2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TAP2_HUMAN
eggNOG	COG1132	http://eggnogapi.embl.de/nog_data/html/tree/COG1132
eggNOG	KOG0058	http://eggnogapi.embl.de/nog_data/html/tree/KOG0058
epestfind	swissprot:TAP2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TAP2_HUMAN
garnier	swissprot:TAP2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TAP2_HUMAN
helixturnhelix	swissprot:TAP2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TAP2_HUMAN
hmoment	swissprot:TAP2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TAP2_HUMAN
iep	swissprot:TAP2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TAP2_HUMAN
inforesidue	swissprot:TAP2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TAP2_HUMAN
neXtProt	NX_Q03519	http://www.nextprot.org/db/entry/NX_Q03519
octanol	swissprot:TAP2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TAP2_HUMAN
pepcoil	swissprot:TAP2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TAP2_HUMAN
pepdigest	swissprot:TAP2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TAP2_HUMAN
pepinfo	swissprot:TAP2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TAP2_HUMAN
pepnet	swissprot:TAP2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TAP2_HUMAN
pepstats	swissprot:TAP2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TAP2_HUMAN
pepwheel	swissprot:TAP2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TAP2_HUMAN
pepwindow	swissprot:TAP2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TAP2_HUMAN
sigcleave	swissprot:TAP2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TAP2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ACHA6_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q15825-1; Sequence=Displayed; Name=2; IsoId=Q15825-2; Sequence=VSP_042713; Note=No experimental confirmation available.; 
# CCDS	CCDS56536	-. [Q15825-2]
# CCDS	CCDS6135	-. [Q15825-1]
# DrugBank	DB00184	Nicotine
# DrugBank	DB00674	Galantamine
# DrugBank	DB00898	Ethanol
# DrugBank	DB01273	Varenicline
# DrugBank	DB09028	Cytisine
# Ensembl	ENST00000276410	ENSP00000276410; ENSG00000147434. [Q15825-1]
# Ensembl	ENST00000534622	ENSP00000433871; ENSG00000147434. [Q15825-2]
# ExpressionAtlas	Q15825	baseline and differential
# FUNCTION	ACHA6_HUMAN	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005892	acetylcholine-gated channel complex; TAS:ProtInc.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0004889	acetylcholine-activated cation-selective channel activity; TAS:ProtInc.
# GO_function	GO:0015276	ligand-gated ion channel activity; TAS:Reactome.
# GO_function	GO:0015464	acetylcholine receptor activity; TAS:ProtInc.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:ProtInc.
# GO_process	GO:0007271	synaptic transmission, cholinergic; IBA:GO_Central.
# GO_process	GO:0007274	neuromuscular synaptic transmission; IBA:GO_Central.
# GO_process	GO:0014059	regulation of dopamine secretion; IEA:Ensembl.
# GO_process	GO:0035094	response to nicotine; IBA:GO_Central.
# GO_process	GO:0051899	membrane depolarization; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.20.120.370	-; 2.
# Gene3D	2.70.170.10	-; 1.
# Genevisible	Q15825	HS
# HGNC	HGNC:15963	CHRNA6
# InterPro	IPR002394	Nicotinic_acetylcholine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# InterPro	IPR027361	Acetylcholine_rcpt_TM
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04725	Cholinergic synapse
# KEGG_Pathway	ko05033	Nicotine addiction
# MIM	606888	gene
# Organism	ACHA6_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR18945	PTHR18945; 2
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00254	NICOTINICR
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-629594	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
# Reactome	R-HSA-629597	Highly calcium permeable nicotinic acetylcholine receptors
# RecName	ACHA6_HUMAN	Neuronal acetylcholine receptor subunit alpha-6
# RefSeq	NP_001186208	NM_001199279.1. [Q15825-2]
# RefSeq	NP_004189	NM_004198.3. [Q15825-1]
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 6/CHRNA6 sub-subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	ACHA6_HUMAN	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Neuronal AChR seems to be composed of two different types of subunits	 alpha and non-alpha (beta). 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TIGRFAMs	TIGR00860	LIC
# UCSC	uc003xpj	human. [Q15825-1]
# eggNOG	ENOG410XQGR	LUCA
# eggNOG	KOG3645	Eukaryota
BLAST	swissprot:ACHA6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ACHA6_HUMAN
BioCyc	ZFISH:ENSG00000147434-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000147434-MONOMER
COXPRESdb	8973	http://coxpresdb.jp/data/gene/8973.shtml
CleanEx	HS_CHRNA6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CHRNA6
DOI	10.1007/BF02736842	http://dx.doi.org/10.1007/BF02736842
DOI	10.1038/nature04406	http://dx.doi.org/10.1038/nature04406
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00184	http://www.drugbank.ca/drugs/DB00184
DrugBank	DB00674	http://www.drugbank.ca/drugs/DB00674
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01273	http://www.drugbank.ca/drugs/DB01273
DrugBank	DB09028	http://www.drugbank.ca/drugs/DB09028
EMBL	AB079251	http://www.ebi.ac.uk/ena/data/view/AB079251
EMBL	AC087533	http://www.ebi.ac.uk/ena/data/view/AC087533
EMBL	AK298798	http://www.ebi.ac.uk/ena/data/view/AK298798
EMBL	AK313521	http://www.ebi.ac.uk/ena/data/view/AK313521
EMBL	BC014456	http://www.ebi.ac.uk/ena/data/view/BC014456
EMBL	CH471080	http://www.ebi.ac.uk/ena/data/view/CH471080
EMBL	U62435	http://www.ebi.ac.uk/ena/data/view/U62435
EMBL	Y16282	http://www.ebi.ac.uk/ena/data/view/Y16282
Ensembl	ENST00000276410	http://www.ensembl.org/id/ENST00000276410
Ensembl	ENST00000534622	http://www.ensembl.org/id/ENST00000534622
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005892	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005892
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0004889	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004889
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_function	GO:0015464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015464
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007271
GO_process	GO:0007274	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007274
GO_process	GO:0014059	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014059
GO_process	GO:0035094	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035094
GO_process	GO:0051899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051899
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.20.120.370	http://www.cathdb.info/version/latest/superfamily/1.20.120.370
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	CHRNA6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CHRNA6
GeneID	8973	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8973
GeneTree	ENSGT00760000118930	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118930
HGNC	HGNC:15963	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:15963
HOGENOM	HOG000006756	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006756&db=HOGENOM6
HOVERGEN	HBG003756	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003756&db=HOVERGEN
InParanoid	Q15825	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q15825
IntAct	Q15825	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q15825*
InterPro	IPR002394	http://www.ebi.ac.uk/interpro/entry/IPR002394
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
InterPro	IPR027361	http://www.ebi.ac.uk/interpro/entry/IPR027361
Jabion	8973	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=8973
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:8973	http://www.genome.jp/dbget-bin/www_bget?hsa:8973
KEGG_Orthology	KO:K04808	http://www.genome.jp/dbget-bin/www_bget?KO:K04808
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04725	http://www.genome.jp/kegg-bin/show_pathway?ko04725
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
MIM	606888	http://www.ncbi.nlm.nih.gov/omim/606888
OMA	CVFTPFF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CVFTPFF
OrthoDB	EOG091G0R20	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0R20
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00254	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00254
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:ACHA6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ACHA6_HUMAN
PSORT-B	swissprot:ACHA6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ACHA6_HUMAN
PSORT2	swissprot:ACHA6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ACHA6_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA26492	http://www.pharmgkb.org/do/serve?objId=PA26492&objCls=Gene
Phobius	swissprot:ACHA6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ACHA6_HUMAN
PhylomeDB	Q15825	http://phylomedb.org/?seqid=Q15825
ProteinModelPortal	Q15825	http://www.proteinmodelportal.org/query/uniprot/Q15825
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16421571	http://www.ncbi.nlm.nih.gov/pubmed/16421571
PubMed	8906617	http://www.ncbi.nlm.nih.gov/pubmed/8906617
Reactome	R-HSA-629594	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-629594
Reactome	R-HSA-629597	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-629597
RefSeq	NP_001186208	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001186208
RefSeq	NP_004189	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004189
STRING	9606.ENSP00000276410	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000276410&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc003xpj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003xpj&org=rat
UniGene	Hs.103128	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.103128
UniProtKB	ACHA6_HUMAN	http://www.uniprot.org/uniprot/ACHA6_HUMAN
UniProtKB-AC	Q15825	http://www.uniprot.org/uniprot/Q15825
charge	swissprot:ACHA6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ACHA6_HUMAN
eggNOG	ENOG410XQGR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQGR
eggNOG	KOG3645	http://eggnogapi.embl.de/nog_data/html/tree/KOG3645
epestfind	swissprot:ACHA6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ACHA6_HUMAN
garnier	swissprot:ACHA6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ACHA6_HUMAN
helixturnhelix	swissprot:ACHA6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACHA6_HUMAN
hmoment	swissprot:ACHA6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ACHA6_HUMAN
iep	swissprot:ACHA6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ACHA6_HUMAN
inforesidue	swissprot:ACHA6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ACHA6_HUMAN
neXtProt	NX_Q15825	http://www.nextprot.org/db/entry/NX_Q15825
octanol	swissprot:ACHA6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ACHA6_HUMAN
pepcoil	swissprot:ACHA6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ACHA6_HUMAN
pepdigest	swissprot:ACHA6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ACHA6_HUMAN
pepinfo	swissprot:ACHA6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ACHA6_HUMAN
pepnet	swissprot:ACHA6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ACHA6_HUMAN
pepstats	swissprot:ACHA6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ACHA6_HUMAN
pepwheel	swissprot:ACHA6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ACHA6_HUMAN
pepwindow	swissprot:ACHA6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ACHA6_HUMAN
sigcleave	swissprot:ACHA6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ACHA6_HUMAN
## Database	ID	URL or Descriptions
# AltName	GHC2_HUMAN	Glutamate/H(+) symporter 2
# AltName	GHC2_HUMAN	Solute carrier family 25 member 18
# BioGrid	123744	3
# Ensembl	ENST00000327451	ENSP00000329033; ENSG00000182902
# Ensembl	ENST00000399813	ENSP00000382710; ENSG00000182902
# ExpressionAtlas	Q9H1K4	baseline and differential
# FUNCTION	GHC2_HUMAN	Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+). {ECO 0000269|PubMed 11897791}. 
# GO_component	GO:0005743	mitochondrial inner membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# Gene3D	1.50.40.10	-; 1.
# Genevisible	Q9H1K4	HS
# HGNC	HGNC:10988	SLC25A18
# INTERACTION	GHC2_HUMAN	Q9HD26 GOPC; NbExp=3; IntAct=EBI-6269587, EBI-349832; 
# IntAct	Q9H1K4	4
# InterPro	IPR002067	Mit_carrier
# InterPro	IPR018108	Mitochondrial_sb/sol_carrier
# InterPro	IPR023395	Mt_carrier_dom
# KEGG_Brite	ko02001	Solute carrier family
# MIM	609303	gene
# Organism	GHC2_HUMAN	Homo sapiens (Human)
# PRINTS	PR00926	MITOCARRIER
# PROSITE	PS50920	SOLCAR; 3
# Pfam	PF00153	Mito_carr; 3
# Proteomes	UP000005640	Chromosome 22
# Reactome	R-HSA-428643	Organic anion transporters
# RecName	GHC2_HUMAN	Mitochondrial glutamate carrier 2
# RefSeq	NP_001290413	NM_001303484.1
# RefSeq	NP_113669	NM_031481.2
# RefSeq	XP_011544453	XM_011546151.2
# RefSeq	XP_011544454	XM_011546152.1
# RefSeq	XP_011544455	XM_011546153.2
# RefSeq	XP_011544456	XM_011546154.2
# RefSeq	XP_016884457	XM_017028968.1
# SIMILARITY	Belongs to the mitochondrial carrier (TC 2.A.29) family. {ECO	0000305}. 
# SIMILARITY	Contains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule	PRU00282}.
# SUBCELLULAR LOCATION	GHC2_HUMAN	Mitochondrion inner membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUPFAM	SSF103506	SSF103506
# TCDB	2.A.29.14	the mitochondrial carrier (mc) family
# UCSC	uc002zmp	human
# eggNOG	ENOG410Y240	LUCA
# eggNOG	KOG0750	Eukaryota
BLAST	swissprot:GHC2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GHC2_HUMAN
BioCyc	ZFISH:G66-31547-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31547-MONOMER
COXPRESdb	83733	http://coxpresdb.jp/data/gene/83733.shtml
CleanEx	HS_SLC25A18	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC25A18
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1074/jbc.M201572200	http://dx.doi.org/10.1074/jbc.M201572200
DOI	10.1101/gr.154901	http://dx.doi.org/10.1101/gr.154901
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/gb-2004-5-10-r84	http://dx.doi.org/10.1186/gb-2004-5-10-r84
EMBL	AJ428203	http://www.ebi.ac.uk/ena/data/view/AJ428203
EMBL	AY008285	http://www.ebi.ac.uk/ena/data/view/AY008285
EMBL	BC031644	http://www.ebi.ac.uk/ena/data/view/BC031644
EMBL	CR456578	http://www.ebi.ac.uk/ena/data/view/CR456578
Ensembl	ENST00000327451	http://www.ensembl.org/id/ENST00000327451
Ensembl	ENST00000399813	http://www.ensembl.org/id/ENST00000399813
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
Gene3D	1.50.40.10	http://www.cathdb.info/version/latest/superfamily/1.50.40.10
GeneCards	SLC25A18	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC25A18
GeneID	83733	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83733
GeneTree	ENSGT00530000062944	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062944
HGNC	HGNC:10988	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10988
HOGENOM	HOG000168308	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000168308&db=HOGENOM6
HOVERGEN	HBG039469	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG039469&db=HOVERGEN
InParanoid	Q9H1K4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9H1K4
IntAct	Q9H1K4	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9H1K4*
InterPro	IPR002067	http://www.ebi.ac.uk/interpro/entry/IPR002067
InterPro	IPR018108	http://www.ebi.ac.uk/interpro/entry/IPR018108
InterPro	IPR023395	http://www.ebi.ac.uk/interpro/entry/IPR023395
Jabion	83733	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=83733
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:83733	http://www.genome.jp/dbget-bin/www_bget?hsa:83733
KEGG_Orthology	KO:K15107	http://www.genome.jp/dbget-bin/www_bget?KO:K15107
MIM	609303	http://www.ncbi.nlm.nih.gov/omim/609303
MINT	MINT-8052484	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8052484
OMA	HQGSASA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HQGSASA
OrthoDB	EOG091G08GT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08GT
PRINTS	PR00926	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00926
PROSITE	PS50920	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50920
PSORT	swissprot:GHC2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GHC2_HUMAN
PSORT-B	swissprot:GHC2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GHC2_HUMAN
PSORT2	swissprot:GHC2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GHC2_HUMAN
Pfam	PF00153	http://pfam.xfam.org/family/PF00153
PharmGKB	PA35864	http://www.pharmgkb.org/do/serve?objId=PA35864&objCls=Gene
Phobius	swissprot:GHC2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GHC2_HUMAN
PhylomeDB	Q9H1K4	http://phylomedb.org/?seqid=Q9H1K4
ProteinModelPortal	Q9H1K4	http://www.proteinmodelportal.org/query/uniprot/Q9H1K4
PubMed	11381032	http://www.ncbi.nlm.nih.gov/pubmed/11381032
PubMed	11897791	http://www.ncbi.nlm.nih.gov/pubmed/11897791
PubMed	15461802	http://www.ncbi.nlm.nih.gov/pubmed/15461802
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
Reactome	R-HSA-428643	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428643
RefSeq	NP_001290413	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001290413
RefSeq	NP_113669	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_113669
RefSeq	XP_011544453	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011544453
RefSeq	XP_011544454	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011544454
RefSeq	XP_011544455	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011544455
RefSeq	XP_011544456	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011544456
RefSeq	XP_016884457	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016884457
STRING	9606.ENSP00000329033	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000329033&targetmode=cogs
SUPFAM	SSF103506	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103506
TCDB	2.A.29.14	http://www.tcdb.org/search/result.php?tc=2.A.29.14
UCSC	uc002zmp	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002zmp&org=rat
UniGene	Hs.282982	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.282982
UniProtKB	GHC2_HUMAN	http://www.uniprot.org/uniprot/GHC2_HUMAN
UniProtKB-AC	Q9H1K4	http://www.uniprot.org/uniprot/Q9H1K4
charge	swissprot:GHC2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GHC2_HUMAN
eggNOG	ENOG410Y240	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y240
eggNOG	KOG0750	http://eggnogapi.embl.de/nog_data/html/tree/KOG0750
epestfind	swissprot:GHC2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GHC2_HUMAN
garnier	swissprot:GHC2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GHC2_HUMAN
helixturnhelix	swissprot:GHC2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GHC2_HUMAN
hmoment	swissprot:GHC2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GHC2_HUMAN
iep	swissprot:GHC2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GHC2_HUMAN
inforesidue	swissprot:GHC2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GHC2_HUMAN
neXtProt	NX_Q9H1K4	http://www.nextprot.org/db/entry/NX_Q9H1K4
octanol	swissprot:GHC2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GHC2_HUMAN
pepcoil	swissprot:GHC2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GHC2_HUMAN
pepdigest	swissprot:GHC2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GHC2_HUMAN
pepinfo	swissprot:GHC2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GHC2_HUMAN
pepnet	swissprot:GHC2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GHC2_HUMAN
pepstats	swissprot:GHC2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GHC2_HUMAN
pepwheel	swissprot:GHC2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GHC2_HUMAN
pepwindow	swissprot:GHC2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GHC2_HUMAN
sigcleave	swissprot:GHC2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GHC2_HUMAN
## Database	ID	URL or Descriptions
# AltName	AP1G2_HUMAN	Gamma2-adaptin
# BioGrid	114420	24
# CAUTION	Does not appear to be a subunit of the clathrin- associated adaptor protein complex 1 (AP-1). {ECO	0000305}. 
# ChiTaRS	AP1G2	human
# Ensembl	ENST00000308724	ENSP00000312442; ENSG00000213983
# Ensembl	ENST00000397120	ENSP00000380309; ENSG00000213983
# ExpressionAtlas	O75843	baseline and differential
# FUNCTION	AP1G2_HUMAN	May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV). {ECO 0000269|PubMed 16867982, ECO 0000269|PubMed 17553870, ECO 0000269|PubMed 9733768}. 
# GO_component	GO:0000139	Golgi membrane; TAS:Reactome.
# GO_component	GO:0005794	Golgi apparatus; TAS:ProtInc.
# GO_component	GO:0005798	Golgi-associated vesicle; IDA:UniProtKB.
# GO_component	GO:0010008	endosome membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0030121	AP-1 adaptor complex; TAS:UniProtKB.
# GO_component	GO:0030133	transport vesicle; IDA:UniProtKB.
# GO_function	GO:0008565	protein transporter activity; IEA:InterPro.
# GO_process	GO:0006886	intracellular protein transport; IEA:InterPro.
# GO_process	GO:0016032	viral process; IEA:UniProtKB-KW.
# GO_process	GO:0016192	vesicle-mediated transport; NAS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# Gene3D	1.25.10.10	-; 1.
# Gene3D	2.60.40.1230	-; 1.
# Genevisible	O75843	HS
# HGNC	HGNC:556	AP1G2
# INTERACTION	AP1G2_HUMAN	Q15276 RABEP1; NbExp=2; IntAct=EBI-373637, EBI-447043; 
# IntAct	O75843	14
# InterPro	IPR002553	Clathrin/coatomer_adapt-like_N
# InterPro	IPR008152	Clathrin_a/b/g-adaptin_app_Ig
# InterPro	IPR008153	Clathrin_g-adaptin_app
# InterPro	IPR011989	ARM-like
# InterPro	IPR013041	Coatomer/clathrin_app_Ig-like
# InterPro	IPR016024	ARM-type_fold
# InterPro	IPR017107	AP1_complex_gsu
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Pathway	ko04142	Lysosome
# MIM	603534	gene
# Organism	AP1G2_HUMAN	Homo sapiens (Human)
# PDB	2E9G	NMR; -; A=662-785
# PDB	2YMT	X-ray; 1.80 A; A=665-785
# PDB	3ZHF	X-ray; 1.70 A; A=665-785
# PDB	4BCX	X-ray; 2.00 A; A=665-785
# PIRSF	PIRSF037094	AP1_complex_gamma
# PROSITE	PS50180	GAE
# Pfam	PF01602	Adaptin_N
# Pfam	PF02883	Alpha_adaptinC2
# Proteomes	UP000005640	Chromosome 14
# Reactome	R-HSA-432720	Lysosome Vesicle Biogenesis
# RecName	AP1G2_HUMAN	AP-1 complex subunit gamma-like 2
# RefSeq	NP_003908	NM_003917.4
# RefSeq	XP_005268229	XM_005268172.3
# RefSeq	XP_005268230	XM_005268173.3
# SEQUENCE CAUTION	Sequence=AAC67390.1; Type=Frameshift; Positions=713; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the adaptor complexes large subunit family. {ECO	0000305}. 
# SIMILARITY	Contains 1 GAE domain. {ECO:0000255|PROSITE- ProRule	PRU00093}. 
# SMART	SM00809	Alpha_adaptinC2
# SUBCELLULAR LOCATION	AP1G2_HUMAN	Golgi apparatus membrane {ECO 0000269|PubMed 11333915, ECO 0000269|PubMed 9762922}; Peripheral membrane protein; Cytoplasmic side {ECO 0000269|PubMed 11333915}. Cytoplasmic vesicle membrane {ECO 0000269|PubMed 9733768}; Peripheral membrane protein. Endosome membrane {ECO 0000269|PubMed 16867982}; Peripheral membrane protein. Note=Mainly localized to perinuclear vesicular structures (PubMed 9733768). Colocalizes with HBV major surface antigen L and HBV core protein C in CD63-containing compartments (PubMed 16867982). Colocalizes with HBV major surface antigen L to cis-Golgi-like structures (PubMed 11333915). 
# SUBUNIT	AP1G2_HUMAN	Probably interacts with AP1S1/Sigma1A-adaptin AP1S2/Sigma1B-adaptin. Probably does not interact with APB1. Interacts with HBV major surface antigen L. Interacts with HBV core protein C in a ubiquitin-dependent manner. Binds ubiquitin. {ECO 0000269|PubMed 11333915, ECO 0000269|PubMed 16867982, ECO 0000269|PubMed 9733768}. 
# SUPFAM	SSF48371	SSF48371
# SUPFAM	SSF49348	SSF49348
# TISSUE SPECIFICITY	AP1G2_HUMAN	Expressed in all but one (skeletal muscle) tissues examined. 
# UCSC	uc001wkl	human
# eggNOG	ENOG410XPKK	LUCA
# eggNOG	KOG1062	Eukaryota
BLAST	swissprot:AP1G2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AP1G2_HUMAN
BioCyc	ZFISH:ENSG00000092051-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000092051-MONOMER
COXPRESdb	8906	http://coxpresdb.jp/data/gene/8906.shtml
CleanEx	HS_AP1G2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AP1G2
DIP	DIP-31185N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31185N
DOI	10.1016/S0014-5793(98)01083-7	http://dx.doi.org/10.1016/S0014-5793(98)01083-7
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1074/jbc.273.38.24693	http://dx.doi.org/10.1074/jbc.273.38.24693
DOI	10.1074/jbc.M603517200	http://dx.doi.org/10.1074/jbc.M603517200
DOI	10.1128/JVI.00479-07	http://dx.doi.org/10.1128/JVI.00479-07
DOI	10.1128/JVI.75.11.5343-5351.2001	http://dx.doi.org/10.1128/JVI.75.11.5343-5351.2001
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AB015318	http://www.ebi.ac.uk/ena/data/view/AB015318
EMBL	AF068706	http://www.ebi.ac.uk/ena/data/view/AF068706
EMBL	CH471078	http://www.ebi.ac.uk/ena/data/view/CH471078
EMBL	CH471078	http://www.ebi.ac.uk/ena/data/view/CH471078
EMBL	CH471078	http://www.ebi.ac.uk/ena/data/view/CH471078
Ensembl	ENST00000308724	http://www.ensembl.org/id/ENST00000308724
Ensembl	ENST00000397120	http://www.ensembl.org/id/ENST00000397120
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005798	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005798
GO_component	GO:0010008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010008
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0030121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030121
GO_component	GO:0030133	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030133
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0006886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006886
GO_process	GO:0016032	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016032
GO_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
Gene3D	2.60.40.1230	http://www.cathdb.info/version/latest/superfamily/2.60.40.1230
GeneCards	AP1G2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=AP1G2
GeneID	8906	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8906
GeneTree	ENSGT00390000012618	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000012618
HGNC	HGNC:556	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:556
HOGENOM	HOG000210271	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000210271&db=HOGENOM6
HOVERGEN	HBG067473	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG067473&db=HOVERGEN
HPA	HPA004106	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA004106
InParanoid	O75843	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O75843
IntAct	O75843	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O75843*
InterPro	IPR002553	http://www.ebi.ac.uk/interpro/entry/IPR002553
InterPro	IPR008152	http://www.ebi.ac.uk/interpro/entry/IPR008152
InterPro	IPR008153	http://www.ebi.ac.uk/interpro/entry/IPR008153
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR013041	http://www.ebi.ac.uk/interpro/entry/IPR013041
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
InterPro	IPR017107	http://www.ebi.ac.uk/interpro/entry/IPR017107
Jabion	8906	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=8906
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Gene	hsa:8906	http://www.genome.jp/dbget-bin/www_bget?hsa:8906
KEGG_Orthology	KO:K12391	http://www.genome.jp/dbget-bin/www_bget?KO:K12391
KEGG_Pathway	ko04142	http://www.genome.jp/kegg-bin/show_pathway?ko04142
MIM	603534	http://www.ncbi.nlm.nih.gov/omim/603534
MINT	MINT-5005892	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5005892
OMA	NVRAMMQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NVRAMMQ
OrthoDB	EOG091G01RV	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01RV
PDB	2E9G	http://www.ebi.ac.uk/pdbe-srv/view/entry/2E9G
PDB	2YMT	http://www.ebi.ac.uk/pdbe-srv/view/entry/2YMT
PDB	3ZHF	http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZHF
PDB	4BCX	http://www.ebi.ac.uk/pdbe-srv/view/entry/4BCX
PDBsum	2E9G	http://www.ebi.ac.uk/pdbsum/2E9G
PDBsum	2YMT	http://www.ebi.ac.uk/pdbsum/2YMT
PDBsum	3ZHF	http://www.ebi.ac.uk/pdbsum/3ZHF
PDBsum	4BCX	http://www.ebi.ac.uk/pdbsum/4BCX
PROSITE	PS50180	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50180
PSORT	swissprot:AP1G2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AP1G2_HUMAN
PSORT-B	swissprot:AP1G2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AP1G2_HUMAN
PSORT2	swissprot:AP1G2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AP1G2_HUMAN
Pfam	PF01602	http://pfam.xfam.org/family/PF01602
Pfam	PF02883	http://pfam.xfam.org/family/PF02883
PharmGKB	PA24846	http://www.pharmgkb.org/do/serve?objId=PA24846&objCls=Gene
Phobius	swissprot:AP1G2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AP1G2_HUMAN
PhylomeDB	O75843	http://phylomedb.org/?seqid=O75843
ProteinModelPortal	O75843	http://www.proteinmodelportal.org/query/uniprot/O75843
PubMed	11333915	http://www.ncbi.nlm.nih.gov/pubmed/11333915
PubMed	16867982	http://www.ncbi.nlm.nih.gov/pubmed/16867982
PubMed	17553870	http://www.ncbi.nlm.nih.gov/pubmed/17553870
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	9733768	http://www.ncbi.nlm.nih.gov/pubmed/9733768
PubMed	9762922	http://www.ncbi.nlm.nih.gov/pubmed/9762922
Reactome	R-HSA-432720	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432720
RefSeq	NP_003908	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003908
RefSeq	XP_005268229	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005268229
RefSeq	XP_005268230	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005268230
SMART	SM00809	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00809
SMR	O75843	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O75843
STRING	9606.ENSP00000312442	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000312442&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
SUPFAM	SSF49348	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49348
UCSC	uc001wkl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001wkl&org=rat
UniGene	Hs.343244	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.343244
UniGene	Hs.569375	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.569375
UniProtKB	AP1G2_HUMAN	http://www.uniprot.org/uniprot/AP1G2_HUMAN
UniProtKB-AC	O75843	http://www.uniprot.org/uniprot/O75843
charge	swissprot:AP1G2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AP1G2_HUMAN
eggNOG	ENOG410XPKK	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPKK
eggNOG	KOG1062	http://eggnogapi.embl.de/nog_data/html/tree/KOG1062
epestfind	swissprot:AP1G2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AP1G2_HUMAN
garnier	swissprot:AP1G2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AP1G2_HUMAN
helixturnhelix	swissprot:AP1G2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AP1G2_HUMAN
hmoment	swissprot:AP1G2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AP1G2_HUMAN
iep	swissprot:AP1G2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AP1G2_HUMAN
inforesidue	swissprot:AP1G2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AP1G2_HUMAN
neXtProt	NX_O75843	http://www.nextprot.org/db/entry/NX_O75843
octanol	swissprot:AP1G2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AP1G2_HUMAN
pepcoil	swissprot:AP1G2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AP1G2_HUMAN
pepdigest	swissprot:AP1G2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AP1G2_HUMAN
pepinfo	swissprot:AP1G2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AP1G2_HUMAN
pepnet	swissprot:AP1G2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AP1G2_HUMAN
pepstats	swissprot:AP1G2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AP1G2_HUMAN
pepwheel	swissprot:AP1G2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AP1G2_HUMAN
pepwindow	swissprot:AP1G2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AP1G2_HUMAN
sigcleave	swissprot:AP1G2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AP1G2_HUMAN
## Database	ID	URL or Descriptions
# CAUTION	Defined as a pseudogene by HGNC. However, proteomic data on a specific peptide from PubMed:17924679 suggest the existence of this protein. {ECO	0000305}.
# CDD	cd12153	F1-ATPase_epsilon
# ChiTaRS	ATP5EP2	human
# Ensembl	ENST00000381026	ENSP00000370414; ENSG00000180389
# FUNCTION	AT5EL_HUMAN	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (By similarity). {ECO 0000250}. 
# GO_component	GO:0000275	mitochondrial proton-transporting ATP synthase complex, catalytic core F(1); IEA:InterPro.
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; IBA:GO_Central.
# GO_function	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism; IEA:InterPro.
# GO_process	GO:0015986	ATP synthesis coupled proton transport; IEA:InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.10.1620.20	-; 1.
# HGNC	HGNC:34026	ATP5EP2
# IntAct	Q5VTU8	13
# InterPro	IPR006721	ATP_synth_F1_esu_mt
# Organism	AT5EL_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12448	PTHR12448
# Pfam	PF04627	ATP-synt_Eps
# Proteomes	UP000005640	Chromosome 13
# RecName	AT5EL_HUMAN	ATP synthase subunit epsilon-like protein, mitochondrial
# SIMILARITY	Belongs to the eukaryotic ATPase epsilon family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	AT5EL_HUMAN	Mitochondrion. Mitochondrion inner membrane {ECO 0000250}. 
# SUBUNIT	F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) seems to have nine subunits	 a, b, c, d, e, f, g, F6 and 8 (or A6L) (By similarity). {ECO:0000250}. 
# SUPFAM	SSF48690	SSF48690
# UCSC	uc001uru	human
# eggNOG	ENOG410Y5P5	LUCA
# eggNOG	KOG3495	Eukaryota
BLAST	swissprot:AT5EL_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AT5EL_HUMAN
BioCyc	ZFISH:HS17497-MONOMER	http://biocyc.org/getid?id=ZFISH:HS17497-MONOMER
DOI	10.1038/nature02379	http://dx.doi.org/10.1038/nature02379
EMBL	AL591024	http://www.ebi.ac.uk/ena/data/view/AL591024
Ensembl	ENST00000381026	http://www.ensembl.org/id/ENST00000381026
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000275	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000275
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_function	GO:0046933	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046933
GO_process	GO:0015986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015986
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.10.1620.20	http://www.cathdb.info/version/latest/superfamily/1.10.1620.20
GeneCards	ATP5EP2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP5EP2
GeneTree	ENSGT00390000015470	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000015470
HGNC	HGNC:34026	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:34026
HOGENOM	HOG000214506	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000214506&db=HOGENOM6
HOVERGEN	HBG050611	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050611&db=HOVERGEN
HPA	HPA042142	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042142
InParanoid	Q5VTU8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q5VTU8
IntAct	Q5VTU8	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q5VTU8*
InterPro	IPR006721	http://www.ebi.ac.uk/interpro/entry/IPR006721
OMA	ANAMKTS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ANAMKTS
OrthoDB	EOG091G16RI	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G16RI
PANTHER	PTHR12448	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12448
PSORT	swissprot:AT5EL_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AT5EL_HUMAN
PSORT-B	swissprot:AT5EL_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AT5EL_HUMAN
PSORT2	swissprot:AT5EL_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AT5EL_HUMAN
Pfam	PF04627	http://pfam.xfam.org/family/PF04627
Phobius	swissprot:AT5EL_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AT5EL_HUMAN
PhylomeDB	Q5VTU8	http://phylomedb.org/?seqid=Q5VTU8
ProteinModelPortal	Q5VTU8	http://www.proteinmodelportal.org/query/uniprot/Q5VTU8
PubMed	15057823	http://www.ncbi.nlm.nih.gov/pubmed/15057823
SMR	Q5VTU8	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q5VTU8
STRING	9606.ENSP00000370414	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000370414&targetmode=cogs
SUPFAM	SSF48690	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48690
UCSC	uc001uru	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001uru&org=rat
UniGene	Hs.574118	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.574118
UniProtKB	AT5EL_HUMAN	http://www.uniprot.org/uniprot/AT5EL_HUMAN
UniProtKB-AC	Q5VTU8	http://www.uniprot.org/uniprot/Q5VTU8
charge	swissprot:AT5EL_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AT5EL_HUMAN
eggNOG	ENOG410Y5P5	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y5P5
eggNOG	KOG3495	http://eggnogapi.embl.de/nog_data/html/tree/KOG3495
epestfind	swissprot:AT5EL_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AT5EL_HUMAN
garnier	swissprot:AT5EL_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AT5EL_HUMAN
helixturnhelix	swissprot:AT5EL_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AT5EL_HUMAN
hmoment	swissprot:AT5EL_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AT5EL_HUMAN
iep	swissprot:AT5EL_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AT5EL_HUMAN
inforesidue	swissprot:AT5EL_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AT5EL_HUMAN
neXtProt	NX_Q5VTU8	http://www.nextprot.org/db/entry/NX_Q5VTU8
octanol	swissprot:AT5EL_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AT5EL_HUMAN
pepcoil	swissprot:AT5EL_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AT5EL_HUMAN
pepdigest	swissprot:AT5EL_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AT5EL_HUMAN
pepinfo	swissprot:AT5EL_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AT5EL_HUMAN
pepnet	swissprot:AT5EL_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AT5EL_HUMAN
pepstats	swissprot:AT5EL_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AT5EL_HUMAN
pepwheel	swissprot:AT5EL_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AT5EL_HUMAN
pepwindow	swissprot:AT5EL_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AT5EL_HUMAN
sigcleave	swissprot:AT5EL_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AT5EL_HUMAN
## Database	ID	URL or Descriptions
# AltName	ATS8_HUMAN	METH-2
# AltName	ATS8_HUMAN	METH-8
# COFACTOR	ATS8_HUMAN	Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000250}; Note=Binds 1 zinc ion per subunit. {ECO 0000250}; 
# DOMAIN	ATS8_HUMAN	The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix. 
# Ensembl	ENST00000257359	ENSP00000257359; ENSG00000134917
# FUNCTION	ATS8_HUMAN	Has anti-angiogenic properties. 
# GO_component	GO:0005578	proteinaceous extracellular matrix; IEA:UniProtKB-SubCell.
# GO_function	GO:0004222	metalloendopeptidase activity; IEA:InterPro.
# GO_function	GO:0005178	integrin binding; TAS:ProtInc.
# GO_function	GO:0008201	heparin binding; IEA:UniProtKB-KW.
# GO_function	GO:0008237	metallopeptidase activity; TAS:ProtInc.
# GO_function	GO:0008270	zinc ion binding; IEA:InterPro.
# GO_function	GO:0009673	low-affinity phosphate transmembrane transporter activity; TAS:ProtInc.
# GO_process	GO:0008285	negative regulation of cell proliferation; TAS:ProtInc.
# GOslim_component	GO:0005578	proteinaceous extracellular matrix
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008233	peptidase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0008150	biological_process
# Gene3D	3.40.390.10	-; 1.
# Genevisible	Q9UP79	HS
# HGNC	HGNC:224	ADAMTS8
# InterPro	IPR000884	TSP1_rpt
# InterPro	IPR001590	Peptidase_M12B
# InterPro	IPR002870	Peptidase_M12B_N
# InterPro	IPR006586	ADAM_Cys-rich
# InterPro	IPR010294	ADAM_spacer1
# InterPro	IPR013273	Peptidase_M12B_ADAM-TS
# InterPro	IPR013277	Pept_M12B_ADAM-TS8
# InterPro	IPR024079	MetalloPept_cat_dom
# KEGG_Brite	ko01000	Enzymes
# KEGG_Brite	ko01002	 Peptidases
# MIM	605175	gene
# Organism	ATS8_HUMAN	Homo sapiens (Human)
# PRINTS	PR01857	ADAMTSFAMILY
# PRINTS	PR01861	ADAMTS8
# PROSITE	PS00142	ZINC_PROTEASE
# PROSITE	PS50092	TSP1; 2
# PROSITE	PS50215	ADAM_MEPRO
# PTM	ATS8_HUMAN	Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)- (S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W- X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity). {ECO 0000250}. 
# PTM	ATS8_HUMAN	The precursor is cleaved by a furin endopeptidase. {ECO 0000250}. 
# Pfam	PF00090	TSP_1; 2
# Pfam	PF01421	Reprolysin
# Pfam	PF01562	Pep_M12B_propep
# Pfam	PF05986	ADAM_spacer1
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-1474228	Degradation of the extracellular matrix
# Reactome	R-HSA-5083635	Defective B3GALTL causes Peters-plus syndrome (PpS)
# Reactome	R-HSA-5173214	O-glycosylation of TSR domain-containing proteins
# RecName	ATS8_HUMAN	A disintegrin and metalloproteinase with thrombospondin motifs 8
# RefSeq	NP_008968	NM_007037.5
# SIMILARITY	Contains 1 disintegrin domain. {ECO	0000305}. 
# SIMILARITY	Contains 1 peptidase M12B domain. {ECO:0000255|PROSITE-ProRule	PRU00276}. 
# SIMILARITY	Contains 2 TSP type-1 domains. {ECO:0000255|PROSITE- ProRule	PRU00210}.
# SMART	SM00209	TSP1; 2
# SMART	SM00608	ACR
# SUBCELLULAR LOCATION	ATS8_HUMAN	Secreted, extracellular space, extracellular matrix {ECO 0000250}. 
# SUPFAM	SSF82895	SSF82895; 2
# TISSUE SPECIFICITY	ATS8_HUMAN	Highly expressed in adult and fetal lung, lower expression in brain, placenta, heart, stomach and fetal brain and kidney. 
# UCSC	uc001qgg	human
# eggNOG	ENOG410XPKZ	LUCA
# eggNOG	KOG3538	Eukaryota
BLAST	swissprot:ATS8_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ATS8_HUMAN
BioCyc	ZFISH:ENSG00000134917-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000134917-MONOMER
COXPRESdb	11095	http://coxpresdb.jp/data/gene/11095.shtml
CleanEx	HS_ADAMTS8	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ADAMTS8
DOI	10.1006/geno.1999.6014	http://dx.doi.org/10.1006/geno.1999.6014
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1074/jbc.274.33.23349	http://dx.doi.org/10.1074/jbc.274.33.23349
EC_number	EC:3.4.24.-	http://www.genome.jp/dbget-bin/www_bget?EC:3.4.24.-
EMBL	AF060153	http://www.ebi.ac.uk/ena/data/view/AF060153
EMBL	AF175283	http://www.ebi.ac.uk/ena/data/view/AF175283
EMBL	AP002986	http://www.ebi.ac.uk/ena/data/view/AP002986
ENZYME	3.4.24.-	http://enzyme.expasy.org/EC/3.4.24.-
Ensembl	ENST00000257359	http://www.ensembl.org/id/ENST00000257359
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005578	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005578
GO_function	GO:0004222	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004222
GO_function	GO:0005178	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005178
GO_function	GO:0008201	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008201
GO_function	GO:0008237	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008237
GO_function	GO:0008270	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270
GO_function	GO:0009673	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009673
GO_process	GO:0008285	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008285
GOslim_component	GO:0005578	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005578
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008233	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	3.40.390.10	http://www.cathdb.info/version/latest/superfamily/3.40.390.10
GeneCards	ADAMTS8	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ADAMTS8
GeneID	11095	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11095
GeneTree	ENSGT00760000118880	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118880
H-InvDB	HIX0026131	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0026131
HGNC	HGNC:224	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:224
HOGENOM	HOG000004799	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000004799&db=HOGENOM6
HOVERGEN	HBG004313	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004313&db=HOVERGEN
HPA	HPA066349	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA066349
InParanoid	Q9UP79	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UP79
IntEnz	3.4.24	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.24
InterPro	IPR000884	http://www.ebi.ac.uk/interpro/entry/IPR000884
InterPro	IPR001590	http://www.ebi.ac.uk/interpro/entry/IPR001590
InterPro	IPR002870	http://www.ebi.ac.uk/interpro/entry/IPR002870
InterPro	IPR006586	http://www.ebi.ac.uk/interpro/entry/IPR006586
InterPro	IPR010294	http://www.ebi.ac.uk/interpro/entry/IPR010294
InterPro	IPR013273	http://www.ebi.ac.uk/interpro/entry/IPR013273
InterPro	IPR013277	http://www.ebi.ac.uk/interpro/entry/IPR013277
InterPro	IPR024079	http://www.ebi.ac.uk/interpro/entry/IPR024079
Jabion	11095	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=11095
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Brite	ko01002	http://www.genome.jp/dbget-bin/www_bget?ko01002
KEGG_Gene	hsa:11095	http://www.genome.jp/dbget-bin/www_bget?hsa:11095
KEGG_Orthology	KO:K08623	http://www.genome.jp/dbget-bin/www_bget?KO:K08623
MIM	605175	http://www.ncbi.nlm.nih.gov/omim/605175
OMA	IQPQGAG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IQPQGAG
OrthoDB	EOG091G00AX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00AX
PRINTS	PR01857	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01857
PRINTS	PR01861	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01861
PROSITE	PS00142	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00142
PROSITE	PS50092	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50092
PROSITE	PS50215	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50215
PSORT	swissprot:ATS8_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ATS8_HUMAN
PSORT-B	swissprot:ATS8_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ATS8_HUMAN
PSORT2	swissprot:ATS8_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ATS8_HUMAN
Pfam	PF00090	http://pfam.xfam.org/family/PF00090
Pfam	PF01421	http://pfam.xfam.org/family/PF01421
Pfam	PF01562	http://pfam.xfam.org/family/PF01562
Pfam	PF05986	http://pfam.xfam.org/family/PF05986
Phobius	swissprot:ATS8_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ATS8_HUMAN
PhylomeDB	Q9UP79	http://phylomedb.org/?seqid=Q9UP79
ProteinModelPortal	Q9UP79	http://www.proteinmodelportal.org/query/uniprot/Q9UP79
PubMed	10438512	http://www.ncbi.nlm.nih.gov/pubmed/10438512
PubMed	10610729	http://www.ncbi.nlm.nih.gov/pubmed/10610729
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
Reactome	R-HSA-1474228	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1474228
Reactome	R-HSA-5083635	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5083635
Reactome	R-HSA-5173214	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5173214
RefSeq	NP_008968	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_008968
SMART	SM00209	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00209
SMART	SM00608	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00608
SMR	Q9UP79	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9UP79
STRING	9606.ENSP00000257359	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000257359&targetmode=cogs
SUPFAM	SSF82895	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82895
UCSC	uc001qgg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001qgg&org=rat
UniGene	Hs.271605	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.271605
UniProtKB	ATS8_HUMAN	http://www.uniprot.org/uniprot/ATS8_HUMAN
UniProtKB-AC	Q9UP79	http://www.uniprot.org/uniprot/Q9UP79
charge	swissprot:ATS8_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ATS8_HUMAN
eggNOG	ENOG410XPKZ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPKZ
eggNOG	KOG3538	http://eggnogapi.embl.de/nog_data/html/tree/KOG3538
epestfind	swissprot:ATS8_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ATS8_HUMAN
garnier	swissprot:ATS8_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ATS8_HUMAN
helixturnhelix	swissprot:ATS8_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATS8_HUMAN
hmoment	swissprot:ATS8_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ATS8_HUMAN
iep	swissprot:ATS8_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ATS8_HUMAN
inforesidue	swissprot:ATS8_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ATS8_HUMAN
neXtProt	NX_Q9UP79	http://www.nextprot.org/db/entry/NX_Q9UP79
octanol	swissprot:ATS8_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ATS8_HUMAN
pepcoil	swissprot:ATS8_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ATS8_HUMAN
pepdigest	swissprot:ATS8_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ATS8_HUMAN
pepinfo	swissprot:ATS8_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ATS8_HUMAN
pepnet	swissprot:ATS8_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ATS8_HUMAN
pepstats	swissprot:ATS8_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ATS8_HUMAN
pepwheel	swissprot:ATS8_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ATS8_HUMAN
pepwindow	swissprot:ATS8_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ATS8_HUMAN
sigcleave	swissprot:ATS8_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ATS8_HUMAN
## Database	ID	URL or Descriptions
# AltName	MYCT_HUMAN	H(+)-myo-inositol symporter
# AltName	MYCT_HUMAN	Solute carrier family 2 member 13
# CDD	cd06174	MFS
# ChiTaRS	SLC2A13	human
# Ensembl	ENST00000280871	ENSP00000280871; ENSG00000151229
# ExpressionAtlas	Q96QE2	baseline and differential
# FUNCTION	MYCT_HUMAN	H(+)-myo-inositol cotransporter. Can also transport related stereoisomers. {ECO 0000269|PubMed 11500374}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0005355	glucose transmembrane transporter activity; IBA:GO_Central.
# GO_function	MYCT_HUMAN	GO 0005351 sugar proton symporter activity; IBA GO_Central.
# GO_function	MYCT_HUMAN	GO 0005366 myo-inositol proton symporter activity; TAS Reactome.
# GO_process	GO:0035428	hexose transmembrane transport; IBA:GO_Central.
# GO_process	GO:0046323	glucose import; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q96QE2	HS
# HGNC	HGNC:15956	SLC2A13
# InterPro	IPR003663	Sugar/inositol_transpt
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR005829	Sugar_transporter_CS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	611036	gene
# Organism	MYCT_HUMAN	Homo sapiens (Human)
# PRINTS	PR00171	SUGRTRNSPORT
# PROSITE	PS00216	SUGAR_TRANSPORT_1
# PROSITE	PS00217	SUGAR_TRANSPORT_2
# PROSITE	PS50850	MFS
# PTM	MYCT_HUMAN	Glycosylated. {ECO 0000269|PubMed 11500374}. 
# Pfam	PF00083	Sugar_tr; 2
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-429593	Inositol transporters
# RecName	MYCT_HUMAN	Proton myo-inositol cotransporter
# RefSeq	NP_443117	NM_052885.3
# SEQUENCE CAUTION	Sequence=AAI17118.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI17120.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305}; Sequence=CAC51116.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
# SIMILARITY	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	MYCT_HUMAN	Membrane {ECO 0000269|PubMed 11500374}; Multi-pass membrane protein {ECO 0000269|PubMed 11500374}. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.1.1.25	the major facilitator superfamily (mfs)
# TIGRFAMs	TIGR00879	SP
# TISSUE SPECIFICITY	Predominantly expressed in the brain. {ECO:0000269|PubMed	11500374}. 
# UCSC	uc010skm	human
# eggNOG	ENOG410XNQK	LUCA
# eggNOG	KOG0254	Eukaryota
BLAST	swissprot:MYCT_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MYCT_HUMAN
BioCyc	ZFISH:ENSG00000151229-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000151229-MONOMER
COG	COG0477	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477
COXPRESdb	114134	http://coxpresdb.jp/data/gene/114134.shtml
CleanEx	HS_SLC2A13	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC2A13
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1093/emboj/20.16.4467	http://dx.doi.org/10.1093/emboj/20.16.4467
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
EMBL	AJ315644	http://www.ebi.ac.uk/ena/data/view/AJ315644
EMBL	BC117117	http://www.ebi.ac.uk/ena/data/view/BC117117
EMBL	BC117119	http://www.ebi.ac.uk/ena/data/view/BC117119
Ensembl	ENST00000280871	http://www.ensembl.org/id/ENST00000280871
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005351	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005351
GO_function	GO:0005355	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005355
GO_function	GO:0005366	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005366
GO_process	GO:0035428	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035428
GO_process	GO:0046323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046323
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC2A13	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC2A13
GeneID	114134	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=114134
GeneTree	ENSGT00850000132274	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00850000132274
H-InvDB	HIX0026507	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0026507
HGNC	HGNC:15956	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:15956
HOGENOM	HOG000202868	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202868&db=HOGENOM6
HOVERGEN	HBG031722	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG031722&db=HOVERGEN
HPA	HPA006584	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA006584
InParanoid	Q96QE2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96QE2
InterPro	IPR003663	http://www.ebi.ac.uk/interpro/entry/IPR003663
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR005829	http://www.ebi.ac.uk/interpro/entry/IPR005829
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	114134	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=114134
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:114134	http://www.genome.jp/dbget-bin/www_bget?hsa:114134
KEGG_Orthology	KO:K08150	http://www.genome.jp/dbget-bin/www_bget?KO:K08150
MIM	611036	http://www.ncbi.nlm.nih.gov/omim/611036
OMA	RKYSLMI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RKYSLMI
OrthoDB	EOG091G046D	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G046D
PRINTS	PR00171	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00171
PROSITE	PS00216	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00216
PROSITE	PS00217	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00217
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:MYCT_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MYCT_HUMAN
PSORT-B	swissprot:MYCT_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MYCT_HUMAN
PSORT2	swissprot:MYCT_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MYCT_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
PharmGKB	PA38066	http://www.pharmgkb.org/do/serve?objId=PA38066&objCls=Gene
Phobius	swissprot:MYCT_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MYCT_HUMAN
PhylomeDB	Q96QE2	http://phylomedb.org/?seqid=Q96QE2
ProteinModelPortal	Q96QE2	http://www.proteinmodelportal.org/query/uniprot/Q96QE2
PubMed	11500374	http://www.ncbi.nlm.nih.gov/pubmed/11500374
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
Reactome	R-HSA-429593	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-429593
RefSeq	NP_443117	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_443117
STRING	9606.ENSP00000280871	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000280871&targetmode=cogs
STRING	COG0477	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.1.25	http://www.tcdb.org/search/result.php?tc=2.A.1.1.25
TIGRFAMs	TIGR00879	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00879
UCSC	uc010skm	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010skm&org=rat
UniGene	Hs.558595	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.558595
UniProtKB	MYCT_HUMAN	http://www.uniprot.org/uniprot/MYCT_HUMAN
UniProtKB-AC	Q96QE2	http://www.uniprot.org/uniprot/Q96QE2
charge	swissprot:MYCT_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MYCT_HUMAN
eggNOG	ENOG410XNQK	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNQK
eggNOG	KOG0254	http://eggnogapi.embl.de/nog_data/html/tree/KOG0254
epestfind	swissprot:MYCT_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MYCT_HUMAN
garnier	swissprot:MYCT_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MYCT_HUMAN
helixturnhelix	swissprot:MYCT_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MYCT_HUMAN
hmoment	swissprot:MYCT_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MYCT_HUMAN
iep	swissprot:MYCT_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MYCT_HUMAN
inforesidue	swissprot:MYCT_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MYCT_HUMAN
neXtProt	NX_Q96QE2	http://www.nextprot.org/db/entry/NX_Q96QE2
octanol	swissprot:MYCT_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MYCT_HUMAN
pepcoil	swissprot:MYCT_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MYCT_HUMAN
pepdigest	swissprot:MYCT_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MYCT_HUMAN
pepinfo	swissprot:MYCT_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MYCT_HUMAN
pepnet	swissprot:MYCT_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MYCT_HUMAN
pepstats	swissprot:MYCT_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MYCT_HUMAN
pepwheel	swissprot:MYCT_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MYCT_HUMAN
pepwindow	swissprot:MYCT_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MYCT_HUMAN
sigcleave	swissprot:MYCT_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MYCT_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	PKD2_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q13563-1; Sequence=Displayed; Name=2; Synonyms=delta6; IsoId=Q13563-2; Sequence=VSP_042479, VSP_042480; Name=3; Synonyms=delta7; IsoId=Q13563-3; Sequence=VSP_042481; Name=4; Synonyms=delta9; IsoId=Q13563-4; Sequence=VSP_042482, VSP_042483; Name=5; Synonyms=delta12/13; IsoId=Q13563-5; Sequence=VSP_042484; Note=Minor isoform.; 
# AltName	PKD2_HUMAN	Autosomal dominant polycystic kidney disease type II protein
# AltName	PKD2_HUMAN	Polycystic kidney disease 2 protein
# AltName	PKD2_HUMAN	Polycystwin
# AltName	PKD2_HUMAN	R48321
# AltName	Transient receptor potential cation channel subfamily P member 2 {ECO:0000312|HGNC	HGNC:9009}
# BioGrid	111328	34
# CCDS	CCDS3627	-. [Q13563-1]
# ChiTaRS	PKD2	human
# DISEASE	PKD2_HUMAN	Polycystic kidney disease 2 (PKD2) [MIM 613095]  A disorder characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. It represents approximately 15% of the cases of autosomal dominant polycystic kidney disease. PKD2 is clinically milder than PKD1 but it has a deleterious impact on overall life expectancy. {ECO 0000269|PubMed 10411676, ECO 0000269|PubMed 10541293, ECO 0000269|PubMed 10835625, ECO 0000269|PubMed 11968093, ECO 0000269|PubMed 12707387, ECO 0000269|PubMed 14993477, ECO 0000269|PubMed 15772804, ECO 0000269|PubMed 21115670, ECO 0000269|PubMed 9326320}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	PKD2_HUMAN	The C-terminal coiled-coil domain binds calcium and undergoes a calcium-induced conformation change. It is implicated in oligomerization and the interaction with PKD1. {ECO 0000269|PubMed 18694932}. 
# Ensembl	ENST00000237596	ENSP00000237596; ENSG00000118762. [Q13563-1]
# ExpressionAtlas	Q13563	baseline and differential
# FUNCTION	PKD2_HUMAN	Functions as a calcium permeable cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed 18695040). PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left/right axis specification downstream of nodal flow  forms a complex with PKD1L1 in cilia to facilitate flow detection in left/right patterning (By similarity). {ECO 0000250|UniProtKB O35245, ECO 0000269|PubMed 18695040}. 
# GO_component	GO:0002133	polycystin complex; ISS:BHF-UCL.
# GO_component	GO:0005737	cytoplasm; IDA:BHF-UCL.
# GO_component	GO:0005783	endoplasmic reticulum; IDA:UniProtKB.
# GO_component	GO:0005789	endoplasmic reticulum membrane; IDA:BHF-UCL.
# GO_component	GO:0005886	plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0005911	cell-cell junction; IEA:Ensembl.
# GO_component	GO:0005929	cilium; ISS:BHF-UCL.
# GO_component	GO:0009925	basal plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0030027	lamellipodium; IDA:BHF-UCL.
# GO_component	GO:0031514	motile cilium; ISS:BHF-UCL.
# GO_component	GO:0036064	ciliary basal body; IDA:MGI.
# GO_component	GO:0045180	basal cortex; IDA:BHF-UCL.
# GO_component	GO:0060170	ciliary membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_component	GO:0071458	integral component of cytoplasmic side of endoplasmic reticulum membrane; IDA:BHF-UCL.
# GO_component	GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane; IDA:BHF-UCL.
# GO_component	GO:0072686	mitotic spindle; IDA:BHF-UCL.
# GO_component	GO:0097730	non-motile cilium; ISS:BHF-UCL.
# GO_function	GO:0005102	receptor binding; IPI:BHF-UCL.
# GO_function	GO:0005244	voltage-gated ion channel activity; IDA:BHF-UCL.
# GO_function	GO:0005245	voltage-gated calcium channel activity; IDA:BHF-UCL.
# GO_function	GO:0005248	voltage-gated sodium channel activity; IDA:BHF-UCL.
# GO_function	GO:0005267	potassium channel activity; ISS:BHF-UCL.
# GO_function	GO:0005509	calcium ion binding; ISS:BHF-UCL.
# GO_function	GO:0008092	cytoskeletal protein binding; IDA:BHF-UCL.
# GO_function	GO:0022843	voltage-gated cation channel activity; IDA:BHF-UCL.
# GO_function	GO:0042802	identical protein binding; IPI:IntAct.
# GO_function	GO:0042803	protein homodimerization activity; IDA:BHF-UCL.
# GO_function	GO:0042805	actinin binding; IDA:BHF-UCL.
# GO_function	GO:0043398	HLH domain binding; IPI:BHF-UCL.
# GO_function	GO:0044325	ion channel binding; IPI:BHF-UCL.
# GO_function	GO:0048763	calcium-induced calcium release activity; IDA:BHF-UCL.
# GO_function	GO:0051117	ATPase binding; ISS:BHF-UCL.
# GO_function	GO:0051219	phosphoprotein binding; IPI:UniProtKB.
# GO_process	GO:0001658	branching involved in ureteric bud morphogenesis; IEP:UniProtKB.
# GO_process	GO:0001889	liver development; IEP:UniProtKB.
# GO_process	GO:0001892	embryonic placenta development; ISS:BHF-UCL.
# GO_process	GO:0001947	heart looping; IMP:BHF-UCL.
# GO_process	GO:0003127	detection of nodal flow; ISS:BHF-UCL.
# GO_process	GO:0006816	calcium ion transport; IDA:BHF-UCL.
# GO_process	GO:0007050	cell cycle arrest; ISS:BHF-UCL.
# GO_process	GO:0007259	JAK-STAT cascade; ISS:BHF-UCL.
# GO_process	GO:0007368	determination of left/right symmetry; ISS:BHF-UCL.
# GO_process	GO:0007507	heart development; IEP:UniProtKB.
# GO_process	GO:0008285	negative regulation of cell proliferation; NAS:BHF-UCL.
# GO_process	GO:0021510	spinal cord development; IEP:UniProtKB.
# GO_process	GO:0021915	neural tube development; IEP:UniProtKB.
# GO_process	GO:0030814	regulation of cAMP metabolic process; ISS:BHF-UCL.
# GO_process	GO:0031587	positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IMP:BHF-UCL.
# GO_process	GO:0031659	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; IDA:BHF-UCL.
# GO_process	GO:0034614	cellular response to reactive oxygen species; NAS:BHF-UCL.
# GO_process	GO:0035502	metanephric part of ureteric bud development; IEP:UniProtKB.
# GO_process	GO:0035725	sodium ion transmembrane transport; IDA:BHF-UCL.
# GO_process	GO:0035904	aorta development; IEP:UniProtKB.
# GO_process	GO:0042127	regulation of cell proliferation; IMP:BHF-UCL.
# GO_process	GO:0042994	cytoplasmic sequestering of transcription factor; IMP:BHF-UCL.
# GO_process	GO:0045429	positive regulation of nitric oxide biosynthetic process; IMP:BHF-UCL.
# GO_process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
# GO_process	GO:0050982	detection of mechanical stimulus; ISS:BHF-UCL.
# GO_process	GO:0051209	release of sequestered calcium ion into cytosol; IDA:BHF-UCL.
# GO_process	GO:0051298	centrosome duplication; NAS:BHF-UCL.
# GO_process	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity; ISS:BHF-UCL.
# GO_process	GO:0060674	placenta blood vessel development; ISS:BHF-UCL.
# GO_process	GO:0061333	renal tubule morphogenesis; ISS:BHF-UCL.
# GO_process	GO:0061441	renal artery morphogenesis; IEP:UniProtKB.
# GO_process	GO:0070588	calcium ion transmembrane transport; IDA:BHF-UCL.
# GO_process	GO:0071158	positive regulation of cell cycle arrest; IMP:BHF-UCL.
# GO_process	GO:0071464	cellular response to hydrostatic pressure; IDA:BHF-UCL.
# GO_process	GO:0071470	cellular response to osmotic stress; IDA:BHF-UCL.
# GO_process	GO:0071498	cellular response to fluid shear stress; IMP:BHF-UCL.
# GO_process	GO:0071910	determination of liver left/right asymmetry; IMP:BHF-UCL.
# GO_process	GO:0072075	metanephric mesenchyme development; IEP:UniProtKB.
# GO_process	GO:0072164	mesonephric tubule development; IEP:UniProtKB.
# GO_process	GO:0072177	mesonephric duct development; IEP:UniProtKB.
# GO_process	GO:0072208	metanephric smooth muscle tissue development; IEP:UniProtKB.
# GO_process	GO:0072214	metanephric cortex development; IEP:UniProtKB.
# GO_process	GO:0072218	metanephric ascending thin limb development; IEP:UniProtKB.
# GO_process	GO:0072219	metanephric cortical collecting duct development; IEP:UniProtKB.
# GO_process	GO:0072235	metanephric distal tubule development; IEP:UniProtKB.
# GO_process	GO:0072284	metanephric S-shaped body morphogenesis; IEP:UniProtKB.
# GO_process	GO:0090279	regulation of calcium ion import; IDA:BHF-UCL.
# GO_process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle; IMP:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005815	microtubule organizing center
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0005929	cilium
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0008092	cytoskeletal protein binding
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.10.238.10	-; 1.
# Gene3D	1.20.120.350	-; 1.
# Genevisible	Q13563	HS
# HGNC	HGNC:9009	PKD2
# INTERACTION	PKD2_HUMAN	Self; NbExp=8; IntAct=EBI-7813714, EBI-7813714; O35387 Hax1 (xeno); NbExp=3; IntAct=EBI-7813714, EBI-642449; Q02363 ID2; NbExp=7; IntAct=EBI-7813714, EBI-713450; Q91908 itpr1 (xeno); NbExp=2; IntAct=EBI-7813714, EBI-9633447; Q6A162 KRT40; NbExp=3; IntAct=EBI-7813714, EBI-10171697; P60410 KRTAP10-8; NbExp=3; IntAct=EBI-7813714, EBI-10171774; P43361 MAGEA8; NbExp=3; IntAct=EBI-7813714, EBI-10182930; P98161 PKD1; NbExp=8; IntAct=EBI-7813714, EBI-1752013; O15162 PLSCR1; NbExp=3; IntAct=EBI-7813714, EBI-740019; P48995 TRPC1; NbExp=3; IntAct=EBI-7813714, EBI-929665; P48995-2 TRPC1; NbExp=4; IntAct=EBI-7813714, EBI-9830970; 
# IntAct	Q13563	22
# InterPro	IPR002048	EF_hand_dom
# InterPro	IPR003915	PKD_2
# InterPro	IPR011992	EF-hand-dom_pair
# InterPro	IPR013122	PKD1_2_channel
# InterPro	IPR027359	Channel_four-helix_dom
# KEGG_Brite	ko03036	Chromosome
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00542	[Developmental disorder; Kidney disease; Liver disease] Polycystic kidney disease
# MIM	173910	gene
# MIM	613095	phenotype
# Organism	PKD2_HUMAN	Homo sapiens (Human)
# Orphanet	730	Autosomal dominant polycystic kidney disease
# PDB	2KLD	NMR; -; A=680-796
# PDB	2KLE	NMR; -; A=680-796
# PDB	2KQ6	NMR; -; A=720-797
# PDB	2Y4Q	NMR; -; A=717-792
# PDB	3HRN	X-ray; 1.90 A; A=833-895
# PDB	3HRO	X-ray; 1.90 A; A=833-872
# PDB	5K47	EM; 4.20 A; A/B/C/D=185-723
# PIR	G02640	G02640
# PRINTS	PR01433	POLYCYSTIN2
# PROSITE	PS50222	EF_HAND_2
# Pfam	PF08016	PKD_channel
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-5620916	VxPx cargo-targeting to cilium
# RecName	PKD2_HUMAN	Polycystin-2
# RefSeq	NP_000288	NM_000297.3. [Q13563-1]
# SIMILARITY	Belongs to the polycystin family. {ECO	0000305}. 
# SIMILARITY	Contains 1 EF-hand domain. {ECO:0000255|PROSITE- ProRule	PRU00448}. 
# SUBCELLULAR LOCATION	PKD2_HUMAN	Cell projection, cilium membrane {ECO 0000269|PubMed 18695040}; Multi-pass membrane protein {ECO 0000255}. Endoplasmic reticulum {ECO 0000269|PubMed 10760273}. 
# SUBUNIT	PKD2_HUMAN	Forms homooligomers. Isoform 1 interacts with PKD1 while isoform 3 does not (By similarity). Interacts with PKD1L1. PKD1 requires the presence of PKD2 for stable expression. Interacts with CD2AP (PubMed 10913159). Interacts with HAX1 (PubMed 10760273). Interacts with NEK8 (By similarity). Part of a complex containing AKAP5, ADCY5, ADCY6 and PDE4C (By similarity). Interacts (via C-terminus) with TRPV4 (via C-terminus) (PubMed 18695040). {ECO 0000250|UniProtKB O35245, ECO 0000269|PubMed 10760273, ECO 0000269|PubMed 10913159, ECO 0000269|PubMed 18695040}. 
# SUPFAM	SSF47473	SSF47473
# TCDB	1.A.5.2	the polycystin cation channel (pcc) family
# TISSUE SPECIFICITY	Strongly expressed in ovary, fetal and adult kidney, testis, and small intestine. Not detected in peripheral leukocytes. {ECO:0000269|PubMed	8650545}. 
# UCSC	uc003hre	human. [Q13563-1]
# WEB RESOURCE	PKD2_HUMAN	Name=Functional Glycomics Gateway - Glycan Binding; Note=Polycystin 2 - Not a C-type lectin; URL="http //www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_205";
# eggNOG	ENOG410XTGE	LUCA
# eggNOG	KOG3599	Eukaryota
BLAST	swissprot:PKD2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:PKD2_HUMAN
BioCyc	ZFISH:ENSG00000118762-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000118762-MONOMER
COXPRESdb	5311	http://coxpresdb.jp/data/gene/5311.shtml
CleanEx	HS_PKD2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_PKD2
DIP	DIP-47455N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47455N
DOI	10.1002/humu.20842	http://dx.doi.org/10.1002/humu.20842
DOI	10.1002/humu.9035	http://dx.doi.org/10.1002/humu.9035
DOI	10.1006/geno.1996.0584	http://dx.doi.org/10.1006/geno.1996.0584
DOI	10.1006/geno.1997.4851	http://dx.doi.org/10.1006/geno.1997.4851
DOI	10.1007/s00109-005-0644-6	http://dx.doi.org/10.1007/s00109-005-0644-6
DOI	10.1016/S0165-6147(00)01832-0	http://dx.doi.org/10.1016/S0165-6147(00)01832-0
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/75981	http://dx.doi.org/10.1038/75981
DOI	10.1046/j.1523-1755.1999.00534.x	http://dx.doi.org/10.1046/j.1523-1755.1999.00534.x
DOI	10.1073/pnas.97.8.4017	http://dx.doi.org/10.1073/pnas.97.8.4017
DOI	10.1074/jbc.M006624200	http://dx.doi.org/10.1074/jbc.M006624200
DOI	10.1074/jbc.M802743200	http://dx.doi.org/10.1074/jbc.M802743200
DOI	10.1074/mcp.M800504-MCP200	http://dx.doi.org/10.1074/mcp.M800504-MCP200
DOI	10.1083/jcb.200805124	http://dx.doi.org/10.1083/jcb.200805124
DOI	10.1086/515497	http://dx.doi.org/10.1086/515497
DOI	10.1093/hmg/ddi356	http://dx.doi.org/10.1093/hmg/ddi356
DOI	10.1093/ndt/gfh083	http://dx.doi.org/10.1093/ndt/gfh083
DOI	10.1093/ndt/gfq720	http://dx.doi.org/10.1093/ndt/gfq720
DOI	10.1097/01.ASN.0000061774.90975.25	http://dx.doi.org/10.1097/01.ASN.0000061774.90975.25
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.272.5266.1339	http://dx.doi.org/10.1126/science.272.5266.1339
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
EMBL	AF004859	http://www.ebi.ac.uk/ena/data/view/AF004859
EMBL	AF004860	http://www.ebi.ac.uk/ena/data/view/AF004860
EMBL	AF004861	http://www.ebi.ac.uk/ena/data/view/AF004861
EMBL	AF004862	http://www.ebi.ac.uk/ena/data/view/AF004862
EMBL	AF004863	http://www.ebi.ac.uk/ena/data/view/AF004863
EMBL	AF004864	http://www.ebi.ac.uk/ena/data/view/AF004864
EMBL	AF004865	http://www.ebi.ac.uk/ena/data/view/AF004865
EMBL	AF004866	http://www.ebi.ac.uk/ena/data/view/AF004866
EMBL	AF004867	http://www.ebi.ac.uk/ena/data/view/AF004867
EMBL	AF004868	http://www.ebi.ac.uk/ena/data/view/AF004868
EMBL	AF004869	http://www.ebi.ac.uk/ena/data/view/AF004869
EMBL	AF004870	http://www.ebi.ac.uk/ena/data/view/AF004870
EMBL	AF004871	http://www.ebi.ac.uk/ena/data/view/AF004871
EMBL	AF004872	http://www.ebi.ac.uk/ena/data/view/AF004872
EMBL	AF004873	http://www.ebi.ac.uk/ena/data/view/AF004873
EMBL	BC112261	http://www.ebi.ac.uk/ena/data/view/BC112261
EMBL	BC112263	http://www.ebi.ac.uk/ena/data/view/BC112263
EMBL	U50928	http://www.ebi.ac.uk/ena/data/view/U50928
EMBL	U56813	http://www.ebi.ac.uk/ena/data/view/U56813
Ensembl	ENST00000237596	http://www.ensembl.org/id/ENST00000237596
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0002133	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002133
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005911	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005911
GO_component	GO:0005929	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005929
GO_component	GO:0009925	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009925
GO_component	GO:0030027	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030027
GO_component	GO:0031514	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031514
GO_component	GO:0036064	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036064
GO_component	GO:0045180	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045180
GO_component	GO:0060170	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060170
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_component	GO:0071458	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071458
GO_component	GO:0071556	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071556
GO_component	GO:0072686	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072686
GO_component	GO:0097730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097730
GO_function	GO:0005102	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005102
GO_function	GO:0005244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005244
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0005248	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005248
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0008092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GO_function	GO:0022843	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022843
GO_function	GO:0042802	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_function	GO:0042805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042805
GO_function	GO:0043398	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043398
GO_function	GO:0044325	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044325
GO_function	GO:0048763	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048763
GO_function	GO:0051117	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051117
GO_function	GO:0051219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051219
GO_process	GO:0001658	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001658
GO_process	GO:0001889	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001889
GO_process	GO:0001892	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001892
GO_process	GO:0001947	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001947
GO_process	GO:0003127	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003127
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0007050	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007050
GO_process	GO:0007259	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007259
GO_process	GO:0007368	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007368
GO_process	GO:0007507	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007507
GO_process	GO:0008285	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008285
GO_process	GO:0021510	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021510
GO_process	GO:0021915	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021915
GO_process	GO:0030814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030814
GO_process	GO:0031587	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031587
GO_process	GO:0031659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031659
GO_process	GO:0034614	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034614
GO_process	GO:0035502	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035502
GO_process	GO:0035725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035725
GO_process	GO:0035904	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035904
GO_process	GO:0042127	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042127
GO_process	GO:0042994	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042994
GO_process	GO:0045429	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045429
GO_process	GO:0045944	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045944
GO_process	GO:0050982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050982
GO_process	GO:0051209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051209
GO_process	GO:0051298	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051298
GO_process	GO:0060315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060315
GO_process	GO:0060674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060674
GO_process	GO:0061333	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061333
GO_process	GO:0061441	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061441
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:0071158	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071158
GO_process	GO:0071464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071464
GO_process	GO:0071470	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071470
GO_process	GO:0071498	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071498
GO_process	GO:0071910	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071910
GO_process	GO:0072075	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072075
GO_process	GO:0072164	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072164
GO_process	GO:0072177	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072177
GO_process	GO:0072208	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072208
GO_process	GO:0072214	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072214
GO_process	GO:0072218	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072218
GO_process	GO:0072219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072219
GO_process	GO:0072235	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072235
GO_process	GO:0072284	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072284
GO_process	GO:0090279	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090279
GO_process	GO:2000134	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000134
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005815	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005815
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0005929	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005929
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0008092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.10.238.10	http://www.cathdb.info/version/latest/superfamily/1.10.238.10
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	PKD2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=PKD2
GeneID	5311	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5311
GeneTree	ENSGT00700000104221	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00700000104221
HGNC	HGNC:9009	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:9009
HOGENOM	HOG000230858	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230858&db=HOGENOM6
HOVERGEN	HBG014945	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG014945&db=HOVERGEN
HPA	CAB004544	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB004544
HPA	HPA015794	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA015794
HPA	HPA055297	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA055297
InParanoid	Q13563	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q13563
IntAct	Q13563	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q13563*
InterPro	IPR002048	http://www.ebi.ac.uk/interpro/entry/IPR002048
InterPro	IPR003915	http://www.ebi.ac.uk/interpro/entry/IPR003915
InterPro	IPR011992	http://www.ebi.ac.uk/interpro/entry/IPR011992
InterPro	IPR013122	http://www.ebi.ac.uk/interpro/entry/IPR013122
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
Jabion	5311	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=5311
KEGG_Brite	ko03036	http://www.genome.jp/dbget-bin/www_bget?ko03036
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00542	http://www.genome.jp/dbget-bin/www_bget?H00542
KEGG_Gene	hsa:5311	http://www.genome.jp/dbget-bin/www_bget?hsa:5311
KEGG_Orthology	KO:K04986	http://www.genome.jp/dbget-bin/www_bget?KO:K04986
MIM	173910	http://www.ncbi.nlm.nih.gov/omim/173910
MIM	613095	http://www.ncbi.nlm.nih.gov/omim/613095
MINT	MINT-6618167	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6618167
OMA	AWSRDNP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AWSRDNP
Orphanet	730	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=730
OrthoDB	EOG091G034F	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G034F
PDB	2KLD	http://www.ebi.ac.uk/pdbe-srv/view/entry/2KLD
PDB	2KLE	http://www.ebi.ac.uk/pdbe-srv/view/entry/2KLE
PDB	2KQ6	http://www.ebi.ac.uk/pdbe-srv/view/entry/2KQ6
PDB	2Y4Q	http://www.ebi.ac.uk/pdbe-srv/view/entry/2Y4Q
PDB	3HRN	http://www.ebi.ac.uk/pdbe-srv/view/entry/3HRN
PDB	3HRO	http://www.ebi.ac.uk/pdbe-srv/view/entry/3HRO
PDB	5K47	http://www.ebi.ac.uk/pdbe-srv/view/entry/5K47
PDBsum	2KLD	http://www.ebi.ac.uk/pdbsum/2KLD
PDBsum	2KLE	http://www.ebi.ac.uk/pdbsum/2KLE
PDBsum	2KQ6	http://www.ebi.ac.uk/pdbsum/2KQ6
PDBsum	2Y4Q	http://www.ebi.ac.uk/pdbsum/2Y4Q
PDBsum	3HRN	http://www.ebi.ac.uk/pdbsum/3HRN
PDBsum	3HRO	http://www.ebi.ac.uk/pdbsum/3HRO
PDBsum	5K47	http://www.ebi.ac.uk/pdbsum/5K47
PRINTS	PR01433	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01433
PROSITE	PS50222	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50222
PSORT	swissprot:PKD2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:PKD2_HUMAN
PSORT-B	swissprot:PKD2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:PKD2_HUMAN
PSORT2	swissprot:PKD2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:PKD2_HUMAN
Pfam	PF08016	http://pfam.xfam.org/family/PF08016
PharmGKB	PA33343	http://www.pharmgkb.org/do/serve?objId=PA33343&objCls=Gene
Phobius	swissprot:PKD2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:PKD2_HUMAN
PhylomeDB	Q13563	http://phylomedb.org/?seqid=Q13563
ProteinModelPortal	Q13563	http://www.proteinmodelportal.org/query/uniprot/Q13563
PubMed	10411676	http://www.ncbi.nlm.nih.gov/pubmed/10411676
PubMed	10541293	http://www.ncbi.nlm.nih.gov/pubmed/10541293
PubMed	10760273	http://www.ncbi.nlm.nih.gov/pubmed/10760273
PubMed	10835625	http://www.ncbi.nlm.nih.gov/pubmed/10835625
PubMed	10913159	http://www.ncbi.nlm.nih.gov/pubmed/10913159
PubMed	11698076	http://www.ncbi.nlm.nih.gov/pubmed/11698076
PubMed	11968093	http://www.ncbi.nlm.nih.gov/pubmed/11968093
PubMed	12707387	http://www.ncbi.nlm.nih.gov/pubmed/12707387
PubMed	14993477	http://www.ncbi.nlm.nih.gov/pubmed/14993477
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15772804	http://www.ncbi.nlm.nih.gov/pubmed/15772804
PubMed	16192288	http://www.ncbi.nlm.nih.gov/pubmed/16192288
PubMed	18694932	http://www.ncbi.nlm.nih.gov/pubmed/18694932
PubMed	18695040	http://www.ncbi.nlm.nih.gov/pubmed/18695040
PubMed	18837007	http://www.ncbi.nlm.nih.gov/pubmed/18837007
PubMed	19139490	http://www.ncbi.nlm.nih.gov/pubmed/19139490
PubMed	21115670	http://www.ncbi.nlm.nih.gov/pubmed/21115670
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	8650545	http://www.ncbi.nlm.nih.gov/pubmed/8650545
PubMed	8954772	http://www.ncbi.nlm.nih.gov/pubmed/8954772
PubMed	9286709	http://www.ncbi.nlm.nih.gov/pubmed/9286709
PubMed	9326320	http://www.ncbi.nlm.nih.gov/pubmed/9326320
Reactome	R-HSA-5620916	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5620916
RefSeq	NP_000288	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000288
SMR	Q13563	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q13563
STRING	9606.ENSP00000237596	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000237596&targetmode=cogs
SUPFAM	SSF47473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47473
TCDB	1.A.5.2	http://www.tcdb.org/search/result.php?tc=1.A.5.2
UCSC	uc003hre	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003hre&org=rat
UniGene	Hs.181272	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.181272
UniProtKB	PKD2_HUMAN	http://www.uniprot.org/uniprot/PKD2_HUMAN
UniProtKB-AC	Q13563	http://www.uniprot.org/uniprot/Q13563
charge	swissprot:PKD2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:PKD2_HUMAN
eggNOG	ENOG410XTGE	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XTGE
eggNOG	KOG3599	http://eggnogapi.embl.de/nog_data/html/tree/KOG3599
epestfind	swissprot:PKD2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:PKD2_HUMAN
garnier	swissprot:PKD2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:PKD2_HUMAN
helixturnhelix	swissprot:PKD2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:PKD2_HUMAN
hmoment	swissprot:PKD2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:PKD2_HUMAN
iep	swissprot:PKD2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:PKD2_HUMAN
inforesidue	swissprot:PKD2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:PKD2_HUMAN
neXtProt	NX_Q13563	http://www.nextprot.org/db/entry/NX_Q13563
octanol	swissprot:PKD2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:PKD2_HUMAN
pepcoil	swissprot:PKD2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:PKD2_HUMAN
pepdigest	swissprot:PKD2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:PKD2_HUMAN
pepinfo	swissprot:PKD2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:PKD2_HUMAN
pepnet	swissprot:PKD2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:PKD2_HUMAN
pepstats	swissprot:PKD2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:PKD2_HUMAN
pepwheel	swissprot:PKD2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:PKD2_HUMAN
pepwindow	swissprot:PKD2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:PKD2_HUMAN
sigcleave	swissprot:PKD2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:PKD2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ZNT10_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6XR72-4; Sequence=Displayed; Name=2; IsoId=Q6XR72-2; Sequence=VSP_029863; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; IsoId=Q6XR72-3; Sequence=VSP_029864, VSP_029865; Note=No experimental confirmation available.; 
# AltName	ZNT10_HUMAN	Solute carrier family 30 member 10
# CCDS	CCDS31026	-. [Q6XR72-4]
# DISEASE	ZNT10_HUMAN	Hypermanganesemia with dystonia 1 (HMNDYT1) [MIM 613280]  A metabolic autosomal recessive disorder characterized by dystonia, parkinsonism, extrapyramidal signs, severe hypermanganesemia, polycythemia, and chronic hepatic disease, including steatosis and cirrhosis. {ECO 0000269|PubMed 22341971, ECO 0000269|PubMed 22341972}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000356609	ENSP00000349018; ENSG00000196660. [Q6XR72-3]
# Ensembl	ENST00000366926	ENSP00000355893; ENSG00000196660. [Q6XR72-4]
# FUNCTION	ZNT10_HUMAN	Plays a pivotal role in manganese transport. Manganese is an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. {ECO 0000269|PubMed 22341971, ECO 0000269|PubMed 22341972}. 
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005385	zinc ion transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0006828	manganese ion transport; IMP:UniProtKB.
# GO_process	GO:0010043	response to zinc ion; IBA:GO_Central.
# GO_process	GO:0061088	regulation of sequestering of zinc ion; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.20.1510.10	-; 2.
# Genevisible	Q6XR72	HS
# HGNC	HGNC:25355	SLC30A10
# INDUCTION	Down-regulated by ZNF658 in response to zinc. {ECO:0000269|PubMed	25582195}. 
# InterPro	IPR002524	Cation_efflux
# InterPro	IPR027469	Cation_efflux_TMD
# KEGG_Brite	ko02001	Solute carrier family
# MIM	611146	gene
# MIM	613280	phenotype
# Organism	ZNT10_HUMAN	Homo sapiens (Human)
# Orphanet	309854	Cirrhosis-dystonia-polycythemia-hypermanganesemia syndrome
# PANTHER	PTHR11562	PTHR11562; 2
# PIR	T50628	T50628
# Pfam	PF01545	Cation_efflux
# Proteomes	UP000005640	Chromosome 1
# RecName	ZNT10_HUMAN	Zinc transporter 10
# RefSeq	NP_061183	NM_018713.2. [Q6XR72-4]
# SEQUENCE CAUTION	Sequence=AAP44332.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in position 427.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	ZNT10_HUMAN	Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	2.A.4.2	the cation diffusion facilitator (cdf) family
# TIGRFAMs	TIGR01297	CDF
# TISSUE SPECIFICITY	Specifically expressed in fetal liver and fetal brain. {ECO:0000269|PubMed	15154973}. 
# UCSC	uc001hlw	human. [Q6XR72-4]
# eggNOG	COG1230	LUCA
# eggNOG	KOG1483	Eukaryota
BLAST	swissprot:ZNT10_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ZNT10_HUMAN
COXPRESdb	55532	http://coxpresdb.jp/data/gene/55532.shtml
CleanEx	HS_SLC30A10	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC30A10
DOI	10.1016/j.ajhg.2012.01.017	http://dx.doi.org/10.1016/j.ajhg.2012.01.017
DOI	10.1016/j.ajhg.2012.01.018	http://dx.doi.org/10.1016/j.ajhg.2012.01.018
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1128/MCB.01298-14	http://dx.doi.org/10.1128/MCB.01298-14
DOI	10.1186/1471-2164-5-32	http://dx.doi.org/10.1186/1471-2164-5-32
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AC093562	http://www.ebi.ac.uk/ena/data/view/AC093562
EMBL	AL359609	http://www.ebi.ac.uk/ena/data/view/AL359609
EMBL	AY212919	http://www.ebi.ac.uk/ena/data/view/AY212919
EMBL	BC036078	http://www.ebi.ac.uk/ena/data/view/BC036078
Ensembl	ENST00000356609	http://www.ensembl.org/id/ENST00000356609
Ensembl	ENST00000366926	http://www.ensembl.org/id/ENST00000366926
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005385
GO_process	GO:0006828	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006828
GO_process	GO:0010043	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010043
GO_process	GO:0061088	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061088
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.20.1510.10	http://www.cathdb.info/version/latest/superfamily/1.20.1510.10
GeneCards	SLC30A10	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC30A10
GeneID	55532	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55532
GeneTree	ENSGT00550000074381	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074381
H-InvDB	HIX0001600	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0001600
HGNC	HGNC:25355	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:25355
HOGENOM	HOG000166089	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000166089&db=HOGENOM6
HOVERGEN	HBG000588	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000588&db=HOVERGEN
HPA	HPA017989	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA017989
InParanoid	Q6XR72	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6XR72
InterPro	IPR002524	http://www.ebi.ac.uk/interpro/entry/IPR002524
InterPro	IPR027469	http://www.ebi.ac.uk/interpro/entry/IPR027469
Jabion	55532	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55532
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:55532	http://www.genome.jp/dbget-bin/www_bget?hsa:55532
KEGG_Orthology	KO:K14697	http://www.genome.jp/dbget-bin/www_bget?KO:K14697
MIM	611146	http://www.ncbi.nlm.nih.gov/omim/611146
MIM	613280	http://www.ncbi.nlm.nih.gov/omim/613280
OMA	AAWFACC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AAWFACC
Orphanet	309854	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=309854
OrthoDB	EOG091G04DT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G04DT
PANTHER	PTHR11562	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11562
PSORT	swissprot:ZNT10_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ZNT10_HUMAN
PSORT-B	swissprot:ZNT10_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ZNT10_HUMAN
PSORT2	swissprot:ZNT10_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ZNT10_HUMAN
Pfam	PF01545	http://pfam.xfam.org/family/PF01545
PharmGKB	PA142670903	http://www.pharmgkb.org/do/serve?objId=PA142670903&objCls=Gene
Phobius	swissprot:ZNT10_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ZNT10_HUMAN
PhylomeDB	Q6XR72	http://phylomedb.org/?seqid=Q6XR72
ProteinModelPortal	Q6XR72	http://www.proteinmodelportal.org/query/uniprot/Q6XR72
PubMed	15154973	http://www.ncbi.nlm.nih.gov/pubmed/15154973
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	22341971	http://www.ncbi.nlm.nih.gov/pubmed/22341971
PubMed	22341972	http://www.ncbi.nlm.nih.gov/pubmed/22341972
PubMed	25582195	http://www.ncbi.nlm.nih.gov/pubmed/25582195
RefSeq	NP_061183	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061183
STRING	9606.ENSP00000355893	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000355893&targetmode=cogs
TCDB	2.A.4.2	http://www.tcdb.org/search/result.php?tc=2.A.4.2
TIGRFAMs	TIGR01297	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01297
UCSC	uc001hlw	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001hlw&org=rat
UniGene	Hs.284450	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.284450
UniProtKB	ZNT10_HUMAN	http://www.uniprot.org/uniprot/ZNT10_HUMAN
UniProtKB-AC	Q6XR72	http://www.uniprot.org/uniprot/Q6XR72
charge	swissprot:ZNT10_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ZNT10_HUMAN
eggNOG	COG1230	http://eggnogapi.embl.de/nog_data/html/tree/COG1230
eggNOG	KOG1483	http://eggnogapi.embl.de/nog_data/html/tree/KOG1483
epestfind	swissprot:ZNT10_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ZNT10_HUMAN
garnier	swissprot:ZNT10_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ZNT10_HUMAN
helixturnhelix	swissprot:ZNT10_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZNT10_HUMAN
hmoment	swissprot:ZNT10_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ZNT10_HUMAN
iep	swissprot:ZNT10_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ZNT10_HUMAN
inforesidue	swissprot:ZNT10_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ZNT10_HUMAN
neXtProt	NX_Q6XR72	http://www.nextprot.org/db/entry/NX_Q6XR72
octanol	swissprot:ZNT10_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ZNT10_HUMAN
pepcoil	swissprot:ZNT10_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ZNT10_HUMAN
pepdigest	swissprot:ZNT10_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ZNT10_HUMAN
pepinfo	swissprot:ZNT10_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ZNT10_HUMAN
pepnet	swissprot:ZNT10_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ZNT10_HUMAN
pepstats	swissprot:ZNT10_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ZNT10_HUMAN
pepwheel	swissprot:ZNT10_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ZNT10_HUMAN
pepwindow	swissprot:ZNT10_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ZNT10_HUMAN
sigcleave	swissprot:ZNT10_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ZNT10_HUMAN
## Database	ID	URL or Descriptions
# AltName	ABCD1_HUMAN	Adrenoleukodystrophy protein
# BRENDA	3.6.3.47	2681
# BioGrid	106717	31
# DISEASE	ABCD1_HUMAN	Adrenoleukodystrophy (ALD) [MIM 300100]  A peroxisomal metabolic disorder characterized by progressive multifocal demyelination of the central nervous system and by peripheral adrenal insufficiency (Addison disease). It results in mental deterioration, corticospinal tract dysfunction, and cortical blindness. Different clinical manifestations exist like  cerebral childhood ALD (CALD), adult cerebral ALD (ACALD), adrenomyeloneuropathy (AMN) and 'Addison disease only' (ADO) phenotype. {ECO 0000269|PubMed 10369742, ECO 0000269|PubMed 10480364, ECO 0000269|PubMed 10737980, ECO 0000269|PubMed 10980539, ECO 0000269|PubMed 11438993, ECO 0000269|PubMed 11810273, ECO 0000269|PubMed 15643618, ECO 0000269|PubMed 21700483, ECO 0000269|PubMed 21889498, ECO 0000269|PubMed 23651979, ECO 0000269|PubMed 26686776, ECO 0000269|PubMed 7581394, ECO 0000269|PubMed 7717396, ECO 0000269|PubMed 7825602, ECO 0000269|PubMed 7849723, ECO 0000269|PubMed 7904210, ECO 0000269|PubMed 8040304, ECO 0000269|PubMed 8566952, ECO 0000269|PubMed 8651290, ECO 0000269|PubMed 9452087}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ABCD1_HUMAN	Note=The promoter region of ABCD1 is deleted in the chromosome Xq28 deletion syndrome which involves ABCD1 and the neighboring gene BCAP31. {ECO 0000269|PubMed 11992258}. 
# Ensembl	ENST00000218104	ENSP00000218104; ENSG00000101986
# ExpressionAtlas	P33897	baseline and differential
# FUNCTION	ABCD1_HUMAN	Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity. {ECO 0000269|PubMed 11248239}. 
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005739	mitochondrion; IEA:Ensembl.
# GO_component	GO:0005777	peroxisome; IDA:UniProtKB.
# GO_component	GO:0005778	peroxisomal membrane; IDA:UniProtKB.
# GO_component	GO:0005779	integral component of peroxisomal membrane; IDA:UniProtKB.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IDA:UniProtKB.
# GO_function	GO:0005215	transporter activity; NAS:UniProtKB.
# GO_function	GO:0005324	long-chain fatty acid transporter activity; EXP:Reactome.
# GO_function	GO:0005325	peroxisomal fatty-acyl-CoA transporter activity; IGI:UniProtKB.
# GO_function	GO:0005524	ATP binding; IDA:UniProtKB.
# GO_function	GO:0016887	ATPase activity; IDA:UniProtKB.
# GO_function	GO:0019899	enzyme binding; IPI:UniProtKB.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; NAS:UniProtKB.
# GO_function	GO:0042803	protein homodimerization activity; IDA:UniProtKB.
# GO_process	GO:0006635	fatty acid beta-oxidation; IDA:UniProtKB.
# GO_process	GO:0007031	peroxisome organization; IDA:UniProtKB.
# GO_process	GO:0015910	peroxisomal long-chain fatty acid import; IGI:UniProtKB.
# GO_process	GO:0015919	peroxisomal membrane transport; NAS:UniProtKB.
# GO_process	GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase; TAS:Reactome.
# GO_process	GO:0036109	alpha-linolenic acid metabolic process; TAS:Reactome.
# GO_process	GO:0042758	long-chain fatty acid catabolic process; IGI:UniProtKB.
# GO_process	GO:0042760	very long-chain fatty acid catabolic process; IDA:UniProtKB.
# GO_process	GO:0043651	linoleic acid metabolic process; TAS:Reactome.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005777	peroxisome
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009056	catabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 1.
# Genevisible	P33897	HS
# HGNC	HGNC:61	ABCD1
# INTERACTION	ABCD1_HUMAN	Self; NbExp=2; IntAct=EBI-81045, EBI-81045; P48410 Abcd1 (xeno); NbExp=2; IntAct=EBI-81045, EBI-81118; P28288 ABCD3; NbExp=2; IntAct=EBI-81045, EBI-80992; P40855 PEX19; NbExp=3; IntAct=EBI-81045, EBI-594747; 
# IntAct	P33897	16
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR005283	FA_transporter
# InterPro	IPR011527	ABC1_TM_dom
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR027417	P-loop_NTPase
# InterPro	IPR031237	ALDP
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Disease	H00176	[Inherited metabolic disease; Neurodegenerative disease; Peroxisomal disease] adrenomyeloneuropathy (AMN)
# KEGG_Pathway	ko02010	ABC transporters
# KEGG_Pathway	ko04146	Peroxisome
# MIM	300100	phenotype
# MIM	300371	gene
# Organism	ABCD1_HUMAN	Homo sapiens (Human)
# Orphanet	139396	X-linked cerebral adrenoleukodystrophy
# Orphanet	139399	Adrenomyeloneuropathy
# Orphanet	369942	CADDS
# PANTHER	PTHR11384:SF21	PTHR11384:SF21
# PIR	G02500	G02500
# PROSITE	PS00211	ABC_TRANSPORTER_1
# PROSITE	PS50893	ABC_TRANSPORTER_2
# PROSITE	PS50929	ABC_TM1F
# Pfam	PF00005	ABC_tran
# Pfam	PF06472	ABC_membrane_2
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-1369062	ABC transporters in lipid homeostasis
# Reactome	R-HSA-2046105	Linoleic acid (LA) metabolism
# Reactome	R-HSA-2046106	alpha-linolenic acid (ALA) metabolism
# Reactome	R-HSA-390247	Beta-oxidation of very long chain fatty acids
# RecName	ABCD1_HUMAN	ATP-binding cassette sub-family D member 1
# RefSeq	NP_000024	NM_000033.3
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule	PRU00441}. 
# SIMILARITY	Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA
# SUBCELLULAR LOCATION	ABCD1_HUMAN	Peroxisome membrane; Multi-pass membrane protein. 
# SUBUNIT	ABCD1_HUMAN	Can form homodimers and heterodimers with ABCD2/ALDR and ABCD3/PMP70. Dimerization is necessary to form an active transporter. Interacts with PEX19. {ECO 0000269|PubMed 10551832, ECO 0000269|PubMed 10704444, ECO 0000269|PubMed 10777694}. 
# SUPFAM	SSF52540	SSF52540
# SUPFAM	SSF90123	SSF90123
# TCDB	3.A.1.203	the atp-binding cassette (abc) superfamily
# TIGRFAMs	TIGR00954	3a01203
# UCSC	uc004fif	human
# WEB RESOURCE	ABCD1_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=P33897";
# WEB RESOURCE	ABCD1_HUMAN	Name=X-ALD gene mutation database; URL="http //www.x-ald.nl/"; 
# eggNOG	COG4178	LUCA
# eggNOG	KOG0064	Eukaryota
BLAST	swissprot:ABCD1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCD1_HUMAN
BioCyc	ZFISH:ENSG00000101986-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000101986-MONOMER
COXPRESdb	215	http://coxpresdb.jp/data/gene/215.shtml
CleanEx	HS_ABCD1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCD1
DOI	10.1002/(SICI)1098-1004(1997)9:6<500::AID-HUMU2>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1997)9:6<500::AID-HUMU2>3.0.CO
DOI	10.1002/(SICI)1098-1004(200004)15:4<348::AID-HUMU7>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(200004)15:4<348::AID-HUMU7>3.0.CO
DOI	10.1002/1098-1004(200009)16:3<271::AID-HUMU15>3.0.CO	http://dx.doi.org/10.1002/1098-1004(200009)16:3<271::AID-HUMU15>3.0.CO
DOI	10.1002/humu.1149	http://dx.doi.org/10.1002/humu.1149
DOI	10.1002/humu.1227	http://dx.doi.org/10.1002/humu.1227
DOI	10.1002/humu.1380060203	http://dx.doi.org/10.1002/humu.1380060203
DOI	10.1002/humu.9303	http://dx.doi.org/10.1002/humu.9303
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/bbrc.2000.2572	http://dx.doi.org/10.1006/bbrc.2000.2572
DOI	10.1006/mcpr.1999.0232	http://dx.doi.org/10.1006/mcpr.1999.0232
DOI	10.1007/BF02265264	http://dx.doi.org/10.1007/BF02265264
DOI	10.1007/s00439-001-0632-z	http://dx.doi.org/10.1007/s00439-001-0632-z
DOI	10.1007/s004399900090	http://dx.doi.org/10.1007/s004399900090
DOI	10.1016/0300-9084(93)90089-B	http://dx.doi.org/10.1016/0300-9084(93)90089-B
DOI	10.1016/S0014-5793(01)02235-9	http://dx.doi.org/10.1016/S0014-5793(01)02235-9
DOI	10.1016/j.cca.2011.08.026	http://dx.doi.org/10.1016/j.cca.2011.08.026
DOI	10.1016/j.cca.2015.12.014	http://dx.doi.org/10.1016/j.cca.2015.12.014
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1016/j.ymgme.2011.05.016	http://dx.doi.org/10.1016/j.ymgme.2011.05.016
DOI	10.1038/361726a0	http://dx.doi.org/10.1038/361726a0
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/jbc.274.46.32738	http://dx.doi.org/10.1074/jbc.274.46.32738
DOI	10.1083/jcb.148.5.931	http://dx.doi.org/10.1083/jcb.148.5.931
DOI	10.1086/340849	http://dx.doi.org/10.1086/340849
DOI	10.1093/hmg/2.11.1949	http://dx.doi.org/10.1093/hmg/2.11.1949
DOI	10.1093/hmg/3.10.1903	http://dx.doi.org/10.1093/hmg/3.10.1903
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1159/000346680	http://dx.doi.org/10.1159/000346680
DOI	10.1172/JCI117363	http://dx.doi.org/10.1172/JCI117363
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	BC015541	http://www.ebi.ac.uk/ena/data/view/BC015541
EMBL	BC025358	http://www.ebi.ac.uk/ena/data/view/BC025358
EMBL	U52111	http://www.ebi.ac.uk/ena/data/view/U52111
EMBL	Z21876	http://www.ebi.ac.uk/ena/data/view/Z21876
EMBL	Z31006	http://www.ebi.ac.uk/ena/data/view/Z31006
EMBL	Z31007	http://www.ebi.ac.uk/ena/data/view/Z31007
EMBL	Z31008	http://www.ebi.ac.uk/ena/data/view/Z31008
EMBL	Z31009	http://www.ebi.ac.uk/ena/data/view/Z31009
EMBL	Z31010	http://www.ebi.ac.uk/ena/data/view/Z31010
EMBL	Z31348	http://www.ebi.ac.uk/ena/data/view/Z31348
Ensembl	ENST00000218104	http://www.ensembl.org/id/ENST00000218104
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005777	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005777
GO_component	GO:0005778	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005778
GO_component	GO:0005779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005779
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0005324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005324
GO_function	GO:0005325	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005325
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GO_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_process	GO:0006635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006635
GO_process	GO:0007031	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007031
GO_process	GO:0015910	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015910
GO_process	GO:0015919	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015919
GO_process	GO:0033540	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033540
GO_process	GO:0036109	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036109
GO_process	GO:0042758	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042758
GO_process	GO:0042760	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042760
GO_process	GO:0043651	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043651
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005777	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005777
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCD1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCD1
GeneID	215	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=215
GeneTree	ENSGT00390000003950	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000003950
HGNC	HGNC:61	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:61
HOGENOM	HOG000206081	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000206081&db=HOGENOM6
HOVERGEN	HBG050438	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050438&db=HOVERGEN
InParanoid	P33897	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33897
IntAct	P33897	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33897*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR005283	http://www.ebi.ac.uk/interpro/entry/IPR005283
InterPro	IPR011527	http://www.ebi.ac.uk/interpro/entry/IPR011527
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
InterPro	IPR031237	http://www.ebi.ac.uk/interpro/entry/IPR031237
Jabion	215	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=215
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Disease	H00176	http://www.genome.jp/dbget-bin/www_bget?H00176
KEGG_Gene	hsa:215	http://www.genome.jp/dbget-bin/www_bget?hsa:215
KEGG_Orthology	KO:K05675	http://www.genome.jp/dbget-bin/www_bget?KO:K05675
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
KEGG_Pathway	ko04146	http://www.genome.jp/kegg-bin/show_pathway?ko04146
MIM	300100	http://www.ncbi.nlm.nih.gov/omim/300100
MIM	300371	http://www.ncbi.nlm.nih.gov/omim/300371
OMA	PRVLCRE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PRVLCRE
Orphanet	139396	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=139396
Orphanet	139399	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=139399
Orphanet	369942	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=369942
OrthoDB	EOG091G04M1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G04M1
PANTHER	PTHR11384:SF21	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11384:SF21
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PROSITE	PS50929	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929
PSORT	swissprot:ABCD1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCD1_HUMAN
PSORT-B	swissprot:ABCD1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCD1_HUMAN
PSORT2	swissprot:ABCD1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCD1_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF06472	http://pfam.xfam.org/family/PF06472
PharmGKB	PA24396	http://www.pharmgkb.org/do/serve?objId=PA24396&objCls=Gene
Phobius	swissprot:ABCD1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCD1_HUMAN
PhylomeDB	P33897	http://phylomedb.org/?seqid=P33897
ProteinModelPortal	P33897	http://www.proteinmodelportal.org/query/uniprot/P33897
PubMed	10369742	http://www.ncbi.nlm.nih.gov/pubmed/10369742
PubMed	10480364	http://www.ncbi.nlm.nih.gov/pubmed/10480364
PubMed	10551832	http://www.ncbi.nlm.nih.gov/pubmed/10551832
PubMed	10704444	http://www.ncbi.nlm.nih.gov/pubmed/10704444
PubMed	10737980	http://www.ncbi.nlm.nih.gov/pubmed/10737980
PubMed	10777694	http://www.ncbi.nlm.nih.gov/pubmed/10777694
PubMed	10980539	http://www.ncbi.nlm.nih.gov/pubmed/10980539
PubMed	11248239	http://www.ncbi.nlm.nih.gov/pubmed/11248239
PubMed	11438993	http://www.ncbi.nlm.nih.gov/pubmed/11438993
PubMed	11748843	http://www.ncbi.nlm.nih.gov/pubmed/11748843
PubMed	11810273	http://www.ncbi.nlm.nih.gov/pubmed/11810273
PubMed	11992258	http://www.ncbi.nlm.nih.gov/pubmed/11992258
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15643618	http://www.ncbi.nlm.nih.gov/pubmed/15643618
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21700483	http://www.ncbi.nlm.nih.gov/pubmed/21700483
PubMed	21889498	http://www.ncbi.nlm.nih.gov/pubmed/21889498
PubMed	23651979	http://www.ncbi.nlm.nih.gov/pubmed/23651979
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	26686776	http://www.ncbi.nlm.nih.gov/pubmed/26686776
PubMed	7581394	http://www.ncbi.nlm.nih.gov/pubmed/7581394
PubMed	7717396	http://www.ncbi.nlm.nih.gov/pubmed/7717396
PubMed	7825602	http://www.ncbi.nlm.nih.gov/pubmed/7825602
PubMed	7849723	http://www.ncbi.nlm.nih.gov/pubmed/7849723
PubMed	7904210	http://www.ncbi.nlm.nih.gov/pubmed/7904210
PubMed	8040304	http://www.ncbi.nlm.nih.gov/pubmed/8040304
PubMed	8441467	http://www.ncbi.nlm.nih.gov/pubmed/8441467
PubMed	8507690	http://www.ncbi.nlm.nih.gov/pubmed/8507690
PubMed	8566952	http://www.ncbi.nlm.nih.gov/pubmed/8566952
PubMed	8651290	http://www.ncbi.nlm.nih.gov/pubmed/8651290
PubMed	9195223	http://www.ncbi.nlm.nih.gov/pubmed/9195223
PubMed	9452087	http://www.ncbi.nlm.nih.gov/pubmed/9452087
Reactome	R-HSA-1369062	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1369062
Reactome	R-HSA-2046105	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2046105
Reactome	R-HSA-2046106	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2046106
Reactome	R-HSA-390247	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-390247
RefSeq	NP_000024	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000024
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
STRING	9606.ENSP00000218104	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000218104&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
SUPFAM	SSF90123	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123
TCDB	3.A.1.203	http://www.tcdb.org/search/result.php?tc=3.A.1.203
TIGRFAMs	TIGR00954	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00954
UCSC	uc004fif	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004fif&org=rat
UniGene	Hs.159546	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.159546
UniProtKB	ABCD1_HUMAN	http://www.uniprot.org/uniprot/ABCD1_HUMAN
UniProtKB-AC	P33897	http://www.uniprot.org/uniprot/P33897
charge	swissprot:ABCD1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCD1_HUMAN
eggNOG	COG4178	http://eggnogapi.embl.de/nog_data/html/tree/COG4178
eggNOG	KOG0064	http://eggnogapi.embl.de/nog_data/html/tree/KOG0064
epestfind	swissprot:ABCD1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCD1_HUMAN
garnier	swissprot:ABCD1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCD1_HUMAN
helixturnhelix	swissprot:ABCD1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCD1_HUMAN
hmoment	swissprot:ABCD1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCD1_HUMAN
iep	swissprot:ABCD1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCD1_HUMAN
inforesidue	swissprot:ABCD1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCD1_HUMAN
neXtProt	NX_P33897	http://www.nextprot.org/db/entry/NX_P33897
octanol	swissprot:ABCD1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCD1_HUMAN
pepcoil	swissprot:ABCD1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCD1_HUMAN
pepdigest	swissprot:ABCD1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCD1_HUMAN
pepinfo	swissprot:ABCD1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCD1_HUMAN
pepnet	swissprot:ABCD1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCD1_HUMAN
pepstats	swissprot:ABCD1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCD1_HUMAN
pepwheel	swissprot:ABCD1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCD1_HUMAN
pepwindow	swissprot:ABCD1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCD1_HUMAN
sigcleave	swissprot:ABCD1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCD1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Asic2a; IsoId=Q16515-1; Sequence=Displayed; Name=2; Synonyms=Asic2b, MDEG2; IsoId=Q16515-2; Sequence=VSP_015590, VSP_015591; Note=No experimental confirmation available. Ref.4 (CAD38879) sequence is in conflict in position: 67	H->R. {ECO:0000305}; 
# AltName	ASIC2_HUMAN	Amiloride-sensitive brain sodium channel
# AltName	ASIC2_HUMAN	Amiloride-sensitive cation channel 1, neuronal
# AltName	ASIC2_HUMAN	Amiloride-sensitive cation channel neuronal 1
# AltName	ASIC2_HUMAN	Brain sodium channel 1
# AltName	ASIC2_HUMAN	Mammalian degenerin homolog
# BioGrid	106558	4
# CCDS	CCDS11276	-. [Q16515-2]
# CCDS	CCDS42296	-. [Q16515-1]
# ChiTaRS	ASIC2	human
# DrugBank	DB00594	Amiloride
# Ensembl	ENST00000225823	ENSP00000225823; ENSG00000108684. [Q16515-2]
# Ensembl	ENST00000359872	ENSP00000352934; ENSG00000108684. [Q16515-1]
# FUNCTION	ASIC2_HUMAN	Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0043025	neuronal cell body; IEA:Ensembl.
# GO_component	GO:0043197	dendritic spine; IEA:Ensembl.
# GO_function	GO:0015280	ligand-gated sodium channel activity; TAS:ProtInc.
# GO_function	GO:0022839	ion gated channel activity; IEA:Ensembl.
# GO_function	GO:0044736	acid-sensing ion channel activity; TAS:Reactome.
# GO_process	GO:0003026	regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback; IEA:Ensembl.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:ProtInc.
# GO_process	GO:0007417	central nervous system development; TAS:ProtInc.
# GO_process	GO:0007422	peripheral nervous system development; TAS:ProtInc.
# GO_process	GO:0007602	phototransduction; IEA:Ensembl.
# GO_process	GO:0007605	sensory perception of sound; IEA:Ensembl.
# GO_process	GO:0010447	response to acidic pH; IEA:Ensembl.
# GO_process	GO:0010468	regulation of gene expression; IMP:UniProtKB.
# GO_process	GO:0015672	monovalent inorganic cation transport; TAS:ProtInc.
# GO_process	GO:0019229	regulation of vasoconstriction; IEA:Ensembl.
# GO_process	GO:0030193	regulation of blood coagulation; IMP:UniProtKB.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0034765	regulation of ion transmembrane transport; IEA:Ensembl.
# GO_process	GO:0035418	protein localization to synapse; IEA:Ensembl.
# GO_process	GO:0042391	regulation of membrane potential; IEA:Ensembl.
# GO_process	GO:0043066	negative regulation of apoptotic process; IEA:Ensembl.
# GO_process	GO:0050915	sensory perception of sour taste; IMP:UniProtKB.
# GO_process	GO:0050974	detection of mechanical stimulus involved in sensory perception; IEA:Ensembl.
# GO_process	GO:0051965	positive regulation of synapse assembly; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0003013	circulatory system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q16515	HS
# HGNC	HGNC:99	ASIC2
# INTERACTION	ASIC2_HUMAN	Q9NRD5 PICK1; NbExp=3; IntAct=EBI-79149, EBI-79165; 
# InterPro	IPR001873	Na+channel_ASC
# InterPro	IPR004724	ENaC
# InterPro	IPR020903	Na+channel_ASC_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04742	Taste transduction
# MIM	601784	gene
# MISCELLANEOUS	Inhibited by anti-inflammatory drugs like salicylic acid (By similarity). Regulated by Zn(2+). {ECO	0000250}. 
# Organism	ASIC2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11690	PTHR11690
# PRINTS	PR01078	AMINACHANNEL
# PROSITE	PS01206	ASC
# Pfam	PF00858	ASC
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	ASIC2_HUMAN	Acid-sensing ion channel 2
# RefSeq	NP_001085	NM_001094.4. [Q16515-1]
# RefSeq	NP_899233	NM_183377.1. [Q16515-2]
# SIMILARITY	Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC2 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	ASIC2_HUMAN	Cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Note=Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes. {ECO 0000250}. 
# SUBUNIT	ASIC2_HUMAN	Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with STOM; this regulates channel activity (By similarity). Interacts with PRKCABP and ASIC3. {ECO 0000250, ECO 0000269|PubMed 10842183, ECO 0000269|PubMed 11802773}. 
# TIGRFAMs	TIGR00859	ENaC
# TISSUE SPECIFICITY	ASIC2_HUMAN	Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary. {ECO 0000269|PubMed 10842183, ECO 0000269|PubMed 8631835}. 
# UCSC	uc002hht	human. [Q16515-1]
BLAST	swissprot:ASIC2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ASIC2_HUMAN
BioCyc	ZFISH:ENSG00000108684-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000108684-MONOMER
COXPRESdb	40	http://coxpresdb.jp/data/gene/40.shtml
CleanEx	HS_ACCN1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ACCN1
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1042/0264-6021:3610443	http://dx.doi.org/10.1042/0264-6021:3610443
DOI	10.1073/pnas.94.4.1459	http://dx.doi.org/10.1073/pnas.94.4.1459
DOI	10.1074/jbc.271.14.7879	http://dx.doi.org/10.1074/jbc.271.14.7879
DOI	10.1074/jbc.271.18.10433	http://dx.doi.org/10.1074/jbc.271.18.10433
DOI	10.1074/jbc.M004114200	http://dx.doi.org/10.1074/jbc.M004114200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DrugBank	DB00594	http://www.drugbank.ca/drugs/DB00594
EMBL	AC003687	http://www.ebi.ac.uk/ena/data/view/AC003687
EMBL	AC004147	http://www.ebi.ac.uk/ena/data/view/AC004147
EMBL	AC005549	http://www.ebi.ac.uk/ena/data/view/AC005549
EMBL	AC008133	http://www.ebi.ac.uk/ena/data/view/AC008133
EMBL	AC011824	http://www.ebi.ac.uk/ena/data/view/AC011824
EMBL	AC015751	http://www.ebi.ac.uk/ena/data/view/AC015751
EMBL	AC024610	http://www.ebi.ac.uk/ena/data/view/AC024610
EMBL	AC024614	http://www.ebi.ac.uk/ena/data/view/AC024614
EMBL	AC025898	http://www.ebi.ac.uk/ena/data/view/AC025898
EMBL	AC027233	http://www.ebi.ac.uk/ena/data/view/AC027233
EMBL	AC078907	http://www.ebi.ac.uk/ena/data/view/AC078907
EMBL	AC123769	http://www.ebi.ac.uk/ena/data/view/AC123769
EMBL	AL834182	http://www.ebi.ac.uk/ena/data/view/AL834182
EMBL	BC075042	http://www.ebi.ac.uk/ena/data/view/BC075042
EMBL	BC075043	http://www.ebi.ac.uk/ena/data/view/BC075043
EMBL	U50352	http://www.ebi.ac.uk/ena/data/view/U50352
EMBL	U53212	http://www.ebi.ac.uk/ena/data/view/U53212
EMBL	U57352	http://www.ebi.ac.uk/ena/data/view/U57352
Ensembl	ENST00000225823	http://www.ensembl.org/id/ENST00000225823
Ensembl	ENST00000359872	http://www.ensembl.org/id/ENST00000359872
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0043197	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043197
GO_function	GO:0015280	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015280
GO_function	GO:0022839	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022839
GO_function	GO:0044736	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044736
GO_process	GO:0003026	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003026
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007417	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007417
GO_process	GO:0007422	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007422
GO_process	GO:0007602	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007602
GO_process	GO:0007605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007605
GO_process	GO:0010447	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010447
GO_process	GO:0010468	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010468
GO_process	GO:0015672	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015672
GO_process	GO:0019229	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019229
GO_process	GO:0030193	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030193
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0034765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034765
GO_process	GO:0035418	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035418
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0043066	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043066
GO_process	GO:0050915	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050915
GO_process	GO:0050974	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050974
GO_process	GO:0051965	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051965
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0003013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003013
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ASIC2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ASIC2
GeneID	40	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=40
GeneTree	ENSGT00760000119120	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119120
HGNC	HGNC:99	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:99
HOGENOM	HOG000247010	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000247010&db=HOGENOM6
HOVERGEN	HBG004150	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004150&db=HOVERGEN
HPA	HPA052112	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA052112
InParanoid	Q16515	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q16515
IntAct	Q16515	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q16515*
InterPro	IPR001873	http://www.ebi.ac.uk/interpro/entry/IPR001873
InterPro	IPR004724	http://www.ebi.ac.uk/interpro/entry/IPR004724
InterPro	IPR020903	http://www.ebi.ac.uk/interpro/entry/IPR020903
Jabion	40	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=40
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:40	http://www.genome.jp/dbget-bin/www_bget?hsa:40
KEGG_Orthology	KO:K04828	http://www.genome.jp/dbget-bin/www_bget?KO:K04828
KEGG_Pathway	ko04742	http://www.genome.jp/kegg-bin/show_pathway?ko04742
MIM	601784	http://www.ncbi.nlm.nih.gov/omim/601784
MINT	MINT-223746	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-223746
OMA	CEHECMA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CEHECMA
OrthoDB	EOG091G053J	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G053J
PANTHER	PTHR11690	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11690
PRINTS	PR01078	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01078
PROSITE	PS01206	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01206
PSORT	swissprot:ASIC2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ASIC2_HUMAN
PSORT-B	swissprot:ASIC2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ASIC2_HUMAN
PSORT2	swissprot:ASIC2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ASIC2_HUMAN
Pfam	PF00858	http://pfam.xfam.org/family/PF00858
PharmGKB	PA24433	http://www.pharmgkb.org/do/serve?objId=PA24433&objCls=Gene
Phobius	swissprot:ASIC2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ASIC2_HUMAN
PhylomeDB	Q16515	http://phylomedb.org/?seqid=Q16515
ProteinModelPortal	Q16515	http://www.proteinmodelportal.org/query/uniprot/Q16515
PubMed	10842183	http://www.ncbi.nlm.nih.gov/pubmed/10842183
PubMed	11802773	http://www.ncbi.nlm.nih.gov/pubmed/11802773
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	8626462	http://www.ncbi.nlm.nih.gov/pubmed/8626462
PubMed	8631835	http://www.ncbi.nlm.nih.gov/pubmed/8631835
PubMed	9037075	http://www.ncbi.nlm.nih.gov/pubmed/9037075
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_001085	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001085
RefSeq	NP_899233	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_899233
SMR	Q16515	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q16515
TIGRFAMs	TIGR00859	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00859
UCSC	uc002hht	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002hht&org=rat
UniGene	Hs.368417	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.368417
UniProtKB	ASIC2_HUMAN	http://www.uniprot.org/uniprot/ASIC2_HUMAN
UniProtKB-AC	Q16515	http://www.uniprot.org/uniprot/Q16515
charge	swissprot:ASIC2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ASIC2_HUMAN
epestfind	swissprot:ASIC2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ASIC2_HUMAN
garnier	swissprot:ASIC2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ASIC2_HUMAN
helixturnhelix	swissprot:ASIC2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ASIC2_HUMAN
hmoment	swissprot:ASIC2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ASIC2_HUMAN
iep	swissprot:ASIC2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ASIC2_HUMAN
inforesidue	swissprot:ASIC2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ASIC2_HUMAN
neXtProt	NX_Q16515	http://www.nextprot.org/db/entry/NX_Q16515
octanol	swissprot:ASIC2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ASIC2_HUMAN
pepcoil	swissprot:ASIC2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ASIC2_HUMAN
pepdigest	swissprot:ASIC2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ASIC2_HUMAN
pepinfo	swissprot:ASIC2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ASIC2_HUMAN
pepnet	swissprot:ASIC2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ASIC2_HUMAN
pepstats	swissprot:ASIC2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ASIC2_HUMAN
pepwheel	swissprot:ASIC2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ASIC2_HUMAN
pepwindow	swissprot:ASIC2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ASIC2_HUMAN
sigcleave	swissprot:ASIC2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ASIC2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TRPV1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8NER1-1; Sequence=Displayed; Name=2; IsoId=Q8NER1-3; Sequence=VSP_056862; 
# AltName	TRPV1_HUMAN	Capsaicin receptor
# AltName	TRPV1_HUMAN	Osm-9-like TRP channel 1
# AltName	TRPV1_HUMAN	Vanilloid receptor 1
# BioGrid	113281	7
# CCDS	CCDS45576	-. [Q8NER1-1]
# DOMAIN	TRPV1_HUMAN	The association domain (AD) is necessary for self- association. {ECO 0000250}. 
# DrugBank	DB00132	Alpha-Linolenic Acid
# DrugBank	DB00159	Icosapent
# DrugBank	DB00168	Aspartame
# DrugBank	DB06774	Capsaicin
# ENZYME REGULATION	Channel activity is activated via the interaction with PIRT and phosphatidylinositol 4,5-bisphosphate (PIP2). Both PIRT and PIP2 are required to activate channel activity (By similarity). The channel is sensitized by ATP binding. Repeated stimulation with capsaicin gives rise to progressively smaller responses, due to desensitization. This desensitization is triggered by the influx of calcium ions and is inhibited by elevated ATP levels. Ca(2+) and CALM displace ATP from its binding site and trigger a conformation change that leads to a closed, desensitized channel. Intracellular PIP2 inhibits desensitization. The double-knot toxin (DkTx) from the Chinese earth tiger tarantula activates the channel and traps it in an open conformation (By similarity). {ECO	0000250}. 
# Ensembl	ENST00000399756	ENSP00000382659; ENSG00000196689. [Q8NER1-1]
# Ensembl	ENST00000399759	ENSP00000382661; ENSG00000196689. [Q8NER1-1]
# Ensembl	ENST00000571088	ENSP00000461007; ENSG00000196689. [Q8NER1-1]
# Ensembl	ENST00000572705	ENSP00000459962; ENSG00000196689. [Q8NER1-1]
# ExpressionAtlas	Q8NER1	baseline and differential
# FUNCTION	TRPV1_HUMAN	Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis. {ECO 0000250|UniProtKB O35433, ECO 0000269|PubMed 11050376, ECO 0000269|PubMed 11226139, ECO 0000269|PubMed 11243859, ECO 0000269|PubMed 12077606}. 
# GO_component	GO:0005829	cytosol; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; ISS:UniProtKB.
# GO_component	GO:0009897	external side of plasma membrane; IEA:Ensembl.
# GO_component	GO:0016021	integral component of membrane; IDA:MGI.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030425	dendrite; IEA:Ensembl.
# GO_component	GO:0031226	intrinsic component of plasma membrane; ISS:UniProtKB.
# GO_component	GO:0032591	dendritic spine membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0043025	neuronal cell body; IEA:Ensembl.
# GO_component	GO:0045211	postsynaptic membrane; ISS:UniProtKB.
# GO_function	GO:0004888	transmembrane signaling receptor activity; ISS:UniProtKB.
# GO_function	GO:0005230	extracellular ligand-gated ion channel activity; IDA:UniProtKB.
# GO_function	GO:0005231	excitatory extracellular ligand-gated ion channel activity; ISS:UniProtKB.
# GO_function	GO:0005262	calcium channel activity; IBA:GO_Central.
# GO_function	GO:0005524	ATP binding; ISS:UniProtKB.
# GO_function	GO:0015278	calcium-release channel activity; ISS:UniProtKB.
# GO_function	GO:0017081	chloride channel regulator activity; IEA:Ensembl.
# GO_function	GO:0035091	phosphatidylinositol binding; ISS:UniProtKB.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_function	GO:0051219	phosphoprotein binding; IPI:UniProtKB.
# GO_function	GO:0097603	temperature-gated ion channel activity; IEA:Ensembl.
# GO_process	GO:0000122	negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
# GO_process	GO:0001660	fever generation; IEA:Ensembl.
# GO_process	GO:0001774	microglial cell activation; IEA:Ensembl.
# GO_process	GO:0002024	diet induced thermogenesis; IEA:Ensembl.
# GO_process	GO:0002790	peptide secretion; IEA:Ensembl.
# GO_process	GO:0006629	lipid metabolic process; IEA:Ensembl.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007166	cell surface receptor signaling pathway; TAS:ProtInc.
# GO_process	GO:0007635	chemosensory behavior; TAS:ProtInc.
# GO_process	GO:0014047	glutamate secretion; IEA:Ensembl.
# GO_process	GO:0034605	cellular response to heat; IDA:UniProtKB.
# GO_process	GO:0043065	positive regulation of apoptotic process; IEA:Ensembl.
# GO_process	GO:0043434	response to peptide hormone; IEA:Ensembl.
# GO_process	GO:0045429	positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
# GO_process	GO:0048266	behavioral response to pain; IEA:Ensembl.
# GO_process	GO:0050954	sensory perception of mechanical stimulus; IEA:Ensembl.
# GO_process	GO:0050955	thermoception; IDA:MGI.
# GO_process	GO:0050960	detection of temperature stimulus involved in thermoception; IEA:Ensembl.
# GO_process	GO:0050965	detection of temperature stimulus involved in sensory perception of pain; IEA:Ensembl.
# GO_process	GO:0050968	detection of chemical stimulus involved in sensory perception of pain; IEA:Ensembl.
# GO_process	GO:0051289	protein homotetramerization; ISS:UniProtKB.
# GO_process	GO:0060083	smooth muscle contraction involved in micturition; IEA:Ensembl.
# GO_process	GO:0060454	positive regulation of gastric acid secretion; IEA:Ensembl.
# GO_process	GO:0070588	calcium ion transmembrane transport; ISS:UniProtKB.
# GO_process	GO:0071312	cellular response to alkaloid; ISS:UniProtKB.
# GO_process	GO:0071318	cellular response to ATP; ISS:UniProtKB.
# GO_process	GO:0071356	cellular response to tumor necrosis factor; IEA:Ensembl.
# GO_process	GO:0071468	cellular response to acidic pH; IDA:UniProtKB.
# GO_process	GO:0071502	cellular response to temperature stimulus; IEA:Ensembl.
# GO_process	GO:0090212	negative regulation of establishment of blood-brain barrier; IEA:Ensembl.
# GO_process	GO:1901594	response to capsazepine; IMP:UniProtKB.
# GO_process	GO:1990035	calcium ion import into cell; IDA:UniProtKB.
# GO_process	GO:1990090	cellular response to nerve growth factor stimulus; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0008289	lipid binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.25.40.20	-; 2.
# Genevisible	Q8NER1	HS
# HGNC	HGNC:12716	TRPV1
# InterPro	IPR002110	Ankyrin_rpt
# InterPro	IPR004729	TRP_channel
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR008347	TRPV1-4_channel
# InterPro	IPR020683	Ankyrin_rpt-contain_dom
# InterPro	IPR024863	TRPV1_channel
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# MIM	602076	gene
# MISCELLANEOUS	TRPV1_HUMAN	Responses evoked by low pH and heat, and capsaicin can be antagonized by capsazepine. 
# Organism	TRPV1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10582:SF17	PTHR10582:SF17; 2
# PIR	JC7621	JC7621
# PRINTS	PR01768	TRPVRECEPTOR
# PROSITE	PS50088	ANK_REPEAT
# PROSITE	PS50297	ANK_REP_REGION
# PTM	TRPV1_HUMAN	Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites, probably including Ser-117 as a major phosphorylation site. Phosphorylation by CAMKII seems to regulate binding to vanilloids. Phosphorylated and modulated by PRKCE, PRKCM and probably PRKCZ. Dephosphorylation by calcineurin seems to lead to receptor desensitization and phosphorylation by CAMKII recovers activity. {ECO 0000250|UniProtKB O35433}. 
# Pfam	PF00520	Ion_trans
# Pfam	PF12796	Ank_2
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-3295583	TRP channels
# RecName	TRPV1_HUMAN	Transient receptor potential cation channel subfamily V member 1
# RefSeq	NP_061197	NM_018727.5. [Q8NER1-1]
# RefSeq	NP_542435	NM_080704.3. [Q8NER1-1]
# RefSeq	NP_542436	NM_080705.3. [Q8NER1-1]
# RefSeq	NP_542437	NM_080706.3. [Q8NER1-1]
# SEQUENCE CAUTION	Sequence=AAG43467.1; Type=Frameshift; Positions=498; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV1 sub-subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 6 ANK repeats. {ECO:0000255|PROSITE- ProRule	PRU00023}. 
# SMART	SM00248	ANK; 4
# SUBCELLULAR LOCATION	TRPV1_HUMAN	Cell junction, synapse, postsynaptic cell membrane {ECO 0000250|UniProtKB O35433}; Multi-pass membrane protein {ECO 0000250|UniProtKB O35433}. Cell projection, dendritic spine membrane {ECO 0000250|UniProtKB O35433}; Multi-pass membrane protein {ECO 0000250|UniProtKB O35433}. Cell membrane {ECO 0000269|PubMed 11050376, ECO 0000269|PubMed 11243859, ECO 0000269|PubMed 12077606}; Multi-pass membrane protein {ECO 0000250|UniProtKB O35433}. Note=Mostly, but not exclusively expressed in postsynaptic dendritic spines. {ECO 0000250|UniProtKB O35433}. 
# SUBUNIT	TRPV1_HUMAN	Interacts with PIRT (By similarity). Homotetramer (By similarity). Interacts with TRPV3 and may also form a heteromeric channel with TRPV3 (PubMed 12077606). Interacts with CALM, PRKCM and CSK. Interacts with PRKCG and NTRK1, probably by forming a trimeric complex (By similarity). Interacts with TMEM100 (By similarity). {ECO 0000250, ECO 0000250|UniProtKB Q704Y3, ECO 0000269|PubMed 12077606}. 
# SUPFAM	SSF48403	SSF48403
# TCDB	1.A.4.2.13	the transient receptor potential ca(2+) channel (trp-cc) family
# TIGRFAMs	TIGR00870	trp
# TISSUE SPECIFICITY	TRPV1_HUMAN	Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level). {ECO 0000269|PubMed 11050376, ECO 0000269|PubMed 11243859, ECO 0000269|PubMed 14987252}. 
# UCSC	uc010vrr	human. [Q8NER1-1]
# WEB RESOURCE	TRPV1_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/TRPV1ID50368ch17p13.html";
# eggNOG	ENOG4110DG4	LUCA
# eggNOG	KOG3676	Eukaryota
BLAST	swissprot:TRPV1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TRPV1_HUMAN
BioCyc	ZFISH:G66-33720-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33720-MONOMER
COXPRESdb	7442	http://coxpresdb.jp/data/gene/7442.shtml
CleanEx	HS_TRPV1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TRPV1
DOI	10.1006/bbrc.2001.4482	http://dx.doi.org/10.1006/bbrc.2001.4482
DOI	10.1016/S0304-3959(00)00353-5	http://dx.doi.org/10.1016/S0304-3959(00)00353-5
DOI	10.1038/nature00894	http://dx.doi.org/10.1038/nature00894
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1038/sj.bjp.0703918	http://dx.doi.org/10.1038/sj.bjp.0703918
DOI	10.1074/jbc.M312577200	http://dx.doi.org/10.1074/jbc.M312577200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1101/gr.GR1547R	http://dx.doi.org/10.1101/gr.GR1547R
DOI	10.1111/j.0906-6705.2004.0178.x	http://dx.doi.org/10.1111/j.0906-6705.2004.0178.x
DrugBank	DB00132	http://www.drugbank.ca/drugs/DB00132
DrugBank	DB00159	http://www.drugbank.ca/drugs/DB00159
DrugBank	DB00168	http://www.drugbank.ca/drugs/DB00168
DrugBank	DB06774	http://www.drugbank.ca/drugs/DB06774
EMBL	AC027796	http://www.ebi.ac.uk/ena/data/view/AC027796
EMBL	AF196175	http://www.ebi.ac.uk/ena/data/view/AF196175
EMBL	AF196176	http://www.ebi.ac.uk/ena/data/view/AF196176
EMBL	AJ272063	http://www.ebi.ac.uk/ena/data/view/AJ272063
EMBL	AJ277028	http://www.ebi.ac.uk/ena/data/view/AJ277028
EMBL	AL136801	http://www.ebi.ac.uk/ena/data/view/AL136801
EMBL	AY131289	http://www.ebi.ac.uk/ena/data/view/AY131289
EMBL	BC132820	http://www.ebi.ac.uk/ena/data/view/BC132820
EMBL	BC136633	http://www.ebi.ac.uk/ena/data/view/BC136633
EMBL	CH471108	http://www.ebi.ac.uk/ena/data/view/CH471108
EMBL	DQ177332	http://www.ebi.ac.uk/ena/data/view/DQ177332
Ensembl	ENST00000399756	http://www.ensembl.org/id/ENST00000399756
Ensembl	ENST00000399759	http://www.ensembl.org/id/ENST00000399759
Ensembl	ENST00000571088	http://www.ensembl.org/id/ENST00000571088
Ensembl	ENST00000572705	http://www.ensembl.org/id/ENST00000572705
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0009897	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009897
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0031226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031226
GO_component	GO:0032591	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032591
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0004888	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004888
GO_function	GO:0005230	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005230
GO_function	GO:0005231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005231
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0015278	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015278
GO_function	GO:0017081	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017081
GO_function	GO:0035091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035091
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_function	GO:0051219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051219
GO_function	GO:0097603	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097603
GO_process	GO:0000122	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000122
GO_process	GO:0001660	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001660
GO_process	GO:0001774	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001774
GO_process	GO:0002024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002024
GO_process	GO:0002790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002790
GO_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007166	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007166
GO_process	GO:0007635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007635
GO_process	GO:0014047	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014047
GO_process	GO:0034605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034605
GO_process	GO:0043065	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043065
GO_process	GO:0043434	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043434
GO_process	GO:0045429	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045429
GO_process	GO:0048266	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048266
GO_process	GO:0050954	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050954
GO_process	GO:0050955	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050955
GO_process	GO:0050960	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050960
GO_process	GO:0050965	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050965
GO_process	GO:0050968	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050968
GO_process	GO:0051289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051289
GO_process	GO:0060083	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060083
GO_process	GO:0060454	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060454
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:0071312	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071312
GO_process	GO:0071318	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071318
GO_process	GO:0071356	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071356
GO_process	GO:0071468	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071468
GO_process	GO:0071502	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071502
GO_process	GO:0090212	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090212
GO_process	GO:1901594	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901594
GO_process	GO:1990035	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990035
GO_process	GO:1990090	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990090
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.25.40.20	http://www.cathdb.info/version/latest/superfamily/1.25.40.20
GeneCards	TRPV1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TRPV1
GeneID	7442	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7442
GeneTree	ENSGT00550000074425	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074425
H-InvDB	HIX0013428	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0013428
H-InvDB	HIX0079948	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0079948
HGNC	HGNC:12716	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:12716
HOGENOM	HOG000234630	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234630&db=HOGENOM6
HOVERGEN	HBG054085	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054085&db=HOVERGEN
InParanoid	Q8NER1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8NER1
InterPro	IPR002110	http://www.ebi.ac.uk/interpro/entry/IPR002110
InterPro	IPR004729	http://www.ebi.ac.uk/interpro/entry/IPR004729
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR008347	http://www.ebi.ac.uk/interpro/entry/IPR008347
InterPro	IPR020683	http://www.ebi.ac.uk/interpro/entry/IPR020683
InterPro	IPR024863	http://www.ebi.ac.uk/interpro/entry/IPR024863
Jabion	7442	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7442
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:7442	http://www.genome.jp/dbget-bin/www_bget?hsa:7442
KEGG_Orthology	KO:K05222	http://www.genome.jp/dbget-bin/www_bget?KO:K05222
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
MIM	602076	http://www.ncbi.nlm.nih.gov/omim/602076
MINT	MINT-4721979	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4721979
PANTHER	PTHR10582:SF17	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10582:SF17
PRINTS	PR01768	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01768
PROSITE	PS50088	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50088
PROSITE	PS50297	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50297
PSORT	swissprot:TRPV1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TRPV1_HUMAN
PSORT-B	swissprot:TRPV1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TRPV1_HUMAN
PSORT2	swissprot:TRPV1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TRPV1_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF12796	http://pfam.xfam.org/family/PF12796
PharmGKB	PA37329	http://www.pharmgkb.org/do/serve?objId=PA37329&objCls=Gene
Phobius	swissprot:TRPV1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TRPV1_HUMAN
PhylomeDB	Q8NER1	http://phylomedb.org/?seqid=Q8NER1
ProteinModelPortal	Q8NER1	http://www.proteinmodelportal.org/query/uniprot/Q8NER1
PubMed	11050376	http://www.ncbi.nlm.nih.gov/pubmed/11050376
PubMed	11226139	http://www.ncbi.nlm.nih.gov/pubmed/11226139
PubMed	11230166	http://www.ncbi.nlm.nih.gov/pubmed/11230166
PubMed	11243859	http://www.ncbi.nlm.nih.gov/pubmed/11243859
PubMed	12077606	http://www.ncbi.nlm.nih.gov/pubmed/12077606
PubMed	14987252	http://www.ncbi.nlm.nih.gov/pubmed/14987252
PubMed	14996838	http://www.ncbi.nlm.nih.gov/pubmed/14996838
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
Reactome	R-HSA-3295583	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3295583
RefSeq	NP_061197	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061197
RefSeq	NP_542435	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_542435
RefSeq	NP_542436	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_542436
RefSeq	NP_542437	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_542437
SMART	SM00248	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00248
SMR	Q8NER1	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8NER1
STRING	9606.ENSP00000459962	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000459962&targetmode=cogs
SUPFAM	SSF48403	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48403
TCDB	1.A.4.2.13	http://www.tcdb.org/search/result.php?tc=1.A.4.2.13
TIGRFAMs	TIGR00870	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00870
UCSC	uc010vrr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010vrr&org=rat
UniGene	Hs.579217	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.579217
UniGene	Hs.655380	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.655380
UniProtKB	TRPV1_HUMAN	http://www.uniprot.org/uniprot/TRPV1_HUMAN
UniProtKB-AC	Q8NER1	http://www.uniprot.org/uniprot/Q8NER1
charge	swissprot:TRPV1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TRPV1_HUMAN
eggNOG	ENOG4110DG4	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110DG4
eggNOG	KOG3676	http://eggnogapi.embl.de/nog_data/html/tree/KOG3676
epestfind	swissprot:TRPV1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TRPV1_HUMAN
garnier	swissprot:TRPV1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TRPV1_HUMAN
helixturnhelix	swissprot:TRPV1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRPV1_HUMAN
hmoment	swissprot:TRPV1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TRPV1_HUMAN
iep	swissprot:TRPV1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TRPV1_HUMAN
inforesidue	swissprot:TRPV1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TRPV1_HUMAN
neXtProt	NX_Q8NER1	http://www.nextprot.org/db/entry/NX_Q8NER1
octanol	swissprot:TRPV1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TRPV1_HUMAN
pepcoil	swissprot:TRPV1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TRPV1_HUMAN
pepdigest	swissprot:TRPV1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TRPV1_HUMAN
pepinfo	swissprot:TRPV1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TRPV1_HUMAN
pepnet	swissprot:TRPV1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TRPV1_HUMAN
pepstats	swissprot:TRPV1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TRPV1_HUMAN
pepwheel	swissprot:TRPV1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TRPV1_HUMAN
pepwindow	swissprot:TRPV1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TRPV1_HUMAN
sigcleave	swissprot:TRPV1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TRPV1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CALCR_HUMAN	Event=Alternative promoter usage, Alternative splicing; Named isoforms=6; Name=1; IsoId=P30988-1; Sequence=Displayed; Name=2; IsoId=P30988-2; Sequence=VSP_053290, VSP_053291; Name=3; IsoId=P30988-3; Sequence=VSP_053289, VSP_053291; Name=4; Synonyms=Delta(1-47)hCT((a)); IsoId=P30988-4; Sequence=VSP_053289; Name=5; Synonyms=HCTR-5; IsoId=P30988-5; Sequence=VSP_053290, VSP_053292, VSP_053293; Name=6; Synonyms=HCTR-6; IsoId=P30988-6; Sequence=VSP_053290, VSP_053291, VSP_053292, VSP_053293; 
# BioGrid	107250	5
# CCDS	CCDS55125	-. [P30988-1]
# CCDS	CCDS5631	-. [P30988-2]
# ChiTaRS	CALCR	human
# DrugBank	DB00017	Salmon Calcitonin
# DrugBank	DB01278	Pramlintide
# Ensembl	ENST00000415529	ENSP00000413179; ENSG00000004948. [P30988-6]
# Ensembl	ENST00000423724	ENSP00000391369; ENSG00000004948. [P30988-5]
# ExpressionAtlas	P30988	baseline and differential
# FUNCTION	CALCR_HUMAN	This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. 
# GO_component	GO:0005623	cell; IEA:GOC.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; NAS:UniProtKB.
# GO_function	GO:0004872	receptor activity; IDA:UniProtKB.
# GO_function	GO:0004948	calcitonin receptor activity; IDA:UniProtKB.
# GO_function	GO:0008565	protein transporter activity; IDA:UniProtKB.
# GO_function	GO:0032841	calcitonin binding; IDA:UniProtKB.
# GO_process	GO:0007166	cell surface receptor signaling pathway; IEA:InterPro.
# GO_process	GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway; IDA:UniProtKB.
# GO_process	GO:0007204	positive regulation of cytosolic calcium ion concentration; IDA:UniProtKB.
# GO_process	GO:0015031	protein transport; IDA:UniProtKB.
# GO_process	GO:0030819	positive regulation of cAMP biosynthetic process; IDA:UniProtKB.
# GO_process	GO:0031623	receptor internalization; IDA:UniProtKB.
# GO_process	GO:0045762	positive regulation of adenylate cyclase activity; IDA:UniProtKB.
# GO_process	GO:0051384	response to glucocorticoid; IDA:UniProtKB.
# GO_process	GO:0072659	protein localization to plasma membrane; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005623	cell
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007009	plasma membrane organization
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0042592	homeostatic process
# Genevisible	P30988	HS
# HGNC	HGNC:1440	CALCR
# IntAct	P30988	8
# InterPro	IPR000832	GPCR_2_secretin-like
# InterPro	IPR001688	GPCR_2_calcitonin_rcpt
# InterPro	IPR001879	GPCR_2_extracellular_dom
# InterPro	IPR003287	GCPR_2_calcitonin_rcpt_fam
# InterPro	IPR017981	GPCR_2-like
# InterPro	IPR017983	GPCR_2_secretin-like_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04030	 G protein-coupled receptors
# KEGG_Disease	H01593	[Skeletal dysplasia] Osteoporosis
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04380	Osteoclast differentiation
# MIM	114131	gene
# Organism	CALCR_HUMAN	Homo sapiens (Human)
# PDB	5II0	X-ray; 2.10 A; A/B/C=43-162
# PIR	I37217	I37217
# PIR	S34486	S34486
# POLYMORPHISM	CALCR_HUMAN	Genetic variations in CALCR may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disruption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture. 
# PRINTS	PR00249	GPCRSECRETIN
# PRINTS	PR00361	CALCITONINR
# PRINTS	PR01350	CTRFAMILY
# PROSITE	PS00649	G_PROTEIN_RECEP_F2_1
# PROSITE	PS00650	G_PROTEIN_RECEP_F2_2
# PROSITE	PS50227	G_PROTEIN_RECEP_F2_3
# PROSITE	PS50261	G_PROTEIN_RECEP_F2_4
# Pfam	PF00002	7tm_2
# Pfam	PF02793	HRM
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-418555	G alpha (s) signalling events
# Reactome	R-HSA-419812	Calcitonin-like ligand receptors
# RecName	CALCR_HUMAN	Calcitonin receptor
# RefSeq	NP_001158209	NM_001164737.1
# RefSeq	NP_001158210	NM_001164738.1
# RefSeq	NP_001733	NM_001742.3
# SEQUENCE CAUTION	Sequence=AAA35640.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the G-protein coupled receptor 2 family. {ECO	0000305}. 
# SMART	SM00008	HormR
# SUBCELLULAR LOCATION	CALCR_HUMAN	Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Interacts with GPRASP2. {ECO:0000269|PubMed	15086532}. 
# TCDB	9.A.14.4	the g-protein-coupled receptor (gpcr) family
# UCSC	uc003umw	human. [P30988-1]
# eggNOG	ENOG410XRS2	LUCA
# eggNOG	KOG4564	Eukaryota
BLAST	swissprot:CALCR_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CALCR_HUMAN
COXPRESdb	799	http://coxpresdb.jp/data/gene/799.shtml
CleanEx	HS_CALCR	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CALCR
DOI	10.1006/bbrc.1995.1562	http://dx.doi.org/10.1006/bbrc.1995.1562
DOI	10.1006/bbrc.1998.8445	http://dx.doi.org/10.1006/bbrc.1998.8445
DOI	10.1006/bbrc.1998.8880	http://dx.doi.org/10.1006/bbrc.1998.8880
DOI	10.1006/bbrc.2000.2842	http://dx.doi.org/10.1006/bbrc.2000.2842
DOI	10.1016/0014-5793(94)80503-2	http://dx.doi.org/10.1016/0014-5793(94)80503-2
DOI	10.1016/S0014-5793(99)01176-X	http://dx.doi.org/10.1016/S0014-5793(99)01176-X
DOI	10.1016/j.gene.2004.08.019	http://dx.doi.org/10.1016/j.gene.2004.08.019
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/hmg/7.13.2129	http://dx.doi.org/10.1093/hmg/7.13.2129
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1110/ps.04682504	http://dx.doi.org/10.1110/ps.04682504
DOI	10.1111/j.1471-4159.2004.02411.x	http://dx.doi.org/10.1111/j.1471-4159.2004.02411.x
DOI	10.1111/j.1476-5381.2012.02197.x	http://dx.doi.org/10.1111/j.1476-5381.2012.02197.x
DOI	10.1126/science.1083423	http://dx.doi.org/10.1126/science.1083423
DOI	10.1172/JCI116046	http://dx.doi.org/10.1172/JCI116046
DOI	10.1210/en.136.12.5377	http://dx.doi.org/10.1210/en.136.12.5377
DOI	10.1210/en.136.5.2047	http://dx.doi.org/10.1210/en.136.5.2047
DrugBank	DB00017	http://www.drugbank.ca/drugs/DB00017
DrugBank	DB01278	http://www.drugbank.ca/drugs/DB01278
EMBL	AB022177	http://www.ebi.ac.uk/ena/data/view/AB022177
EMBL	AB022178	http://www.ebi.ac.uk/ena/data/view/AB022178
EMBL	AC003078	http://www.ebi.ac.uk/ena/data/view/AC003078
EMBL	AC005024	http://www.ebi.ac.uk/ena/data/view/AC005024
EMBL	AJ831406	http://www.ebi.ac.uk/ena/data/view/AJ831406
EMBL	AJ831407	http://www.ebi.ac.uk/ena/data/view/AJ831407
EMBL	AK313996	http://www.ebi.ac.uk/ena/data/view/AK313996
EMBL	AY430048	http://www.ebi.ac.uk/ena/data/view/AY430048
EMBL	BC069611	http://www.ebi.ac.uk/ena/data/view/BC069611
EMBL	BC075028	http://www.ebi.ac.uk/ena/data/view/BC075028
EMBL	CH236949	http://www.ebi.ac.uk/ena/data/view/CH236949
EMBL	CH471091	http://www.ebi.ac.uk/ena/data/view/CH471091
EMBL	FN994995	http://www.ebi.ac.uk/ena/data/view/FN994995
EMBL	FN994996	http://www.ebi.ac.uk/ena/data/view/FN994996
EMBL	L00587	http://www.ebi.ac.uk/ena/data/view/L00587
EMBL	S77875	http://www.ebi.ac.uk/ena/data/view/S77875
EMBL	S77876	http://www.ebi.ac.uk/ena/data/view/S77876
EMBL	U26553	http://www.ebi.ac.uk/ena/data/view/U26553
EMBL	U26554	http://www.ebi.ac.uk/ena/data/view/U26554
EMBL	X69920	http://www.ebi.ac.uk/ena/data/view/X69920
EMBL	X82466	http://www.ebi.ac.uk/ena/data/view/X82466
Ensembl	ENST00000415529	http://www.ensembl.org/id/ENST00000415529
Ensembl	ENST00000423724	http://www.ensembl.org/id/ENST00000423724
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005623	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005623
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0004872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004872
GO_function	GO:0004948	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004948
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0032841	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032841
GO_process	GO:0007166	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007166
GO_process	GO:0007189	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007189
GO_process	GO:0007204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007204
GO_process	GO:0015031	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031
GO_process	GO:0030819	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030819
GO_process	GO:0031623	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031623
GO_process	GO:0045762	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045762
GO_process	GO:0051384	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051384
GO_process	GO:0072659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072659
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005623	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005623
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007009
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GeneCards	CALCR	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CALCR
GeneID	799	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=799
GeneTree	ENSGT00760000118800	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118800
H-InvDB	HIX0033513	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0033513
HGNC	HGNC:1440	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1440
HOGENOM	HOG000230695	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230695&db=HOGENOM6
HOVERGEN	HBG102129	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG102129&db=HOVERGEN
HPA	HPA028962	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA028962
InParanoid	P30988	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30988
IntAct	P30988	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30988*
InterPro	IPR000832	http://www.ebi.ac.uk/interpro/entry/IPR000832
InterPro	IPR001688	http://www.ebi.ac.uk/interpro/entry/IPR001688
InterPro	IPR001879	http://www.ebi.ac.uk/interpro/entry/IPR001879
InterPro	IPR003287	http://www.ebi.ac.uk/interpro/entry/IPR003287
InterPro	IPR017981	http://www.ebi.ac.uk/interpro/entry/IPR017981
InterPro	IPR017983	http://www.ebi.ac.uk/interpro/entry/IPR017983
Jabion	799	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=799
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04030	http://www.genome.jp/dbget-bin/www_bget?ko04030
KEGG_Disease	H01593	http://www.genome.jp/dbget-bin/www_bget?H01593
KEGG_Gene	hsa:799	http://www.genome.jp/dbget-bin/www_bget?hsa:799
KEGG_Orthology	KO:K04576	http://www.genome.jp/dbget-bin/www_bget?KO:K04576
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04380	http://www.genome.jp/kegg-bin/show_pathway?ko04380
MIM	114131	http://www.ncbi.nlm.nih.gov/omim/114131
MINT	MINT-1217503	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1217503
PDB	5II0	http://www.ebi.ac.uk/pdbe-srv/view/entry/5II0
PDBsum	5II0	http://www.ebi.ac.uk/pdbsum/5II0
PRINTS	PR00249	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00249
PRINTS	PR00361	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00361
PRINTS	PR01350	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01350
PROSITE	PS00649	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00649
PROSITE	PS00650	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00650
PROSITE	PS50227	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50227
PROSITE	PS50261	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50261
PSORT	swissprot:CALCR_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CALCR_HUMAN
PSORT-B	swissprot:CALCR_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CALCR_HUMAN
PSORT2	swissprot:CALCR_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CALCR_HUMAN
Pfam	PF00002	http://pfam.xfam.org/family/PF00002
Pfam	PF02793	http://pfam.xfam.org/family/PF02793
PharmGKB	PA26032	http://www.pharmgkb.org/do/serve?objId=PA26032&objCls=Gene
Phobius	swissprot:CALCR_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CALCR_HUMAN
ProteinModelPortal	P30988	http://www.proteinmodelportal.org/query/uniprot/P30988
PubMed	10570950	http://www.ncbi.nlm.nih.gov/pubmed/10570950
PubMed	10860825	http://www.ncbi.nlm.nih.gov/pubmed/10860825
PubMed	12690205	http://www.ncbi.nlm.nih.gov/pubmed/12690205
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	1331173	http://www.ncbi.nlm.nih.gov/pubmed/1331173
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15086532	http://www.ncbi.nlm.nih.gov/pubmed/15086532
PubMed	15340161	http://www.ncbi.nlm.nih.gov/pubmed/15340161
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15563840	http://www.ncbi.nlm.nih.gov/pubmed/15563840
PubMed	22946511	http://www.ncbi.nlm.nih.gov/pubmed/22946511
PubMed	7588285	http://www.ncbi.nlm.nih.gov/pubmed/7588285
PubMed	7720653	http://www.ncbi.nlm.nih.gov/pubmed/7720653
PubMed	7733946	http://www.ncbi.nlm.nih.gov/pubmed/7733946
PubMed	8078488	http://www.ncbi.nlm.nih.gov/pubmed/8078488
PubMed	8143880	http://www.ncbi.nlm.nih.gov/pubmed/8143880
PubMed	9571205	http://www.ncbi.nlm.nih.gov/pubmed/9571205
PubMed	9675109	http://www.ncbi.nlm.nih.gov/pubmed/9675109
PubMed	9817931	http://www.ncbi.nlm.nih.gov/pubmed/9817931
Reactome	R-HSA-418555	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418555
Reactome	R-HSA-419812	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-419812
RefSeq	NP_001158209	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001158209
RefSeq	NP_001158210	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001158210
RefSeq	NP_001733	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001733
SMART	SM00008	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00008
SMR	P30988	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30988
STRING	9606.ENSP00000352561	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000352561&targetmode=cogs
TCDB	9.A.14.4	http://www.tcdb.org/search/result.php?tc=9.A.14.4
UCSC	uc003umw	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003umw&org=rat
UniGene	Hs.489127	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.489127
UniProtKB	CALCR_HUMAN	http://www.uniprot.org/uniprot/CALCR_HUMAN
UniProtKB-AC	P30988	http://www.uniprot.org/uniprot/P30988
charge	swissprot:CALCR_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CALCR_HUMAN
eggNOG	ENOG410XRS2	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRS2
eggNOG	KOG4564	http://eggnogapi.embl.de/nog_data/html/tree/KOG4564
epestfind	swissprot:CALCR_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CALCR_HUMAN
garnier	swissprot:CALCR_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CALCR_HUMAN
helixturnhelix	swissprot:CALCR_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CALCR_HUMAN
hmoment	swissprot:CALCR_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CALCR_HUMAN
iep	swissprot:CALCR_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CALCR_HUMAN
inforesidue	swissprot:CALCR_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CALCR_HUMAN
neXtProt	NX_P30988	http://www.nextprot.org/db/entry/NX_P30988
octanol	swissprot:CALCR_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CALCR_HUMAN
pepcoil	swissprot:CALCR_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CALCR_HUMAN
pepdigest	swissprot:CALCR_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CALCR_HUMAN
pepinfo	swissprot:CALCR_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CALCR_HUMAN
pepnet	swissprot:CALCR_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CALCR_HUMAN
pepstats	swissprot:CALCR_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CALCR_HUMAN
pepwheel	swissprot:CALCR_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CALCR_HUMAN
pepwindow	swissprot:CALCR_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CALCR_HUMAN
sigcleave	swissprot:CALCR_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CALCR_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNT1_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q5JUK3-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q5JUK3-2; Sequence=VSP_015470, VSP_015471; Note=No experimental confirmation available.; Name=3; IsoId=Q5JUK3-3; Sequence=VSP_015470, VSP_015471, VSP_044476; Note=No experimental confirmation available.; Name=4; IsoId=Q5JUK3-4; Sequence=VSP_055700, VSP_055701, VSP_015471; Note=No experimental confirmation available.; 
# AltName	KCNT1_HUMAN	KCa4.1
# CCDS	CCDS35175	-. [Q5JUK3-3]
# CCDS	CCDS65188	-. [Q5JUK3-4]
# ChiTaRS	KCNT1	human
# DISEASE	KCNT1_HUMAN	Epilepsy, nocturnal frontal lobe, 5 (ENFL5) [MIM 615005]  An autosomal dominant focal epilepsy syndrome characterized by childhood onset of clusters of motor seizures during sleep. Some patients may develop behavioral or psychiatric manifestations and/or intellectual disability. The phenotype is more severe than observed in other genetic forms of nocturnal frontal lobe epilepsy. {ECO 0000269|PubMed 23086396}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	KCNT1_HUMAN	Epileptic encephalopathy, early infantile, 14 (EIEE14) [MIM 614959]  A rare epileptic encephalopathy of infancy that combines pharmacoresistant seizures with developmental delay. This severe neurologic disorder is characterized by onset in the first 6 months of life of refractory focal seizures and arrest of psychomotor development. Ictal EEG shows discharges that arise randomly from various areas of both hemispheres and migrate from one brain region to another. {ECO 0000269|PubMed 23086397}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000371757	ENSP00000360822; ENSG00000107147. [Q5JUK3-3]
# Ensembl	ENST00000487664	ENSP00000417851; ENSG00000107147. [Q5JUK3-2]
# Ensembl	ENST00000488444	ENSP00000419007; ENSG00000107147. [Q5JUK3-1]
# Ensembl	ENST00000628528	ENSP00000486374; ENSG00000107147. [Q5JUK3-4]
# ExpressionAtlas	Q5JUK3	baseline and differential
# FUNCTION	KCNT1_HUMAN	Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity). {ECO 0000250}. 
# GO_component	GO:0008076	voltage-gated potassium channel complex; IBA:GO_Central.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IBA:GO_Central.
# GO_function	GO:0015269	calcium-activated potassium channel activity; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# Gene3D	3.40.50.720	-; 2.
# Genevisible	Q5JUK3	HS
# HGNC	HGNC:18865	KCNT1
# InterPro	IPR003929	K_chnl_Ca-activ_BK_asu
# InterPro	IPR013099	K_chnl_dom
# InterPro	IPR016040	NAD(P)-bd_dom
# KEGG_Brite	ko04040	Ion channels
# MIM	608167	gene
# MIM	614959	phenotype
# MIM	615005	phenotype
# Organism	KCNT1_HUMAN	Homo sapiens (Human)
# Orphanet	293181	Malignant migrating partial seizures of infancy
# Orphanet	98784	Autosomal dominant nocturnal frontal lobe epilepsy
# PTM	KCNT1_HUMAN	Phosphorylated by protein kinase C. Phosphorylation of the C- terminal domain increases channel activity (By similarity). {ECO 0000250}. 
# Pfam	PF03493	BK_channel_a
# Pfam	PF07885	Ion_trans_2
# Proteomes	UP000005640	Chromosome 9
# RecName	KCNT1_HUMAN	Potassium channel subfamily T member 1
# RefSeq	NP_001258932	NM_001272003.1. [Q5JUK3-4]
# RefSeq	NP_065873	NM_020822.2. [Q5JUK3-3]
# SEQUENCE CAUTION	Sequence=BAA92660.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the potassium channel family. Calcium- activated (TC 1.A.1.3) subfamily. KCa4.1/KCNT1 sub-subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 RCK N-terminal domain. {ECO	0000305}. 
# SUBCELLULAR LOCATION	KCNT1_HUMAN	Cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUBUNIT	KCNT1_HUMAN	Interacts (via C-terminus) with FMR1; this interaction alters gating properties of KCNT1 (PubMed 20512134). Interacts with CRBN via its cytoplasmic C-terminus (By similarity). {ECO 0000250|UniProtKB Q9Z258, ECO 0000269|PubMed 20512134}. 
# TISSUE SPECIFICITY	Highest expression in liver, brain and spinal cord. Lowest expression in skeletal muscle. {ECO:0000269|PubMed	10718198}. 
# UCSC	uc011mdq	human. [Q5JUK3-1]
# eggNOG	ENOG410XSMA	LUCA
# eggNOG	KOG3193	Eukaryota
BLAST	swissprot:KCNT1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNT1_HUMAN
COXPRESdb	57582	http://coxpresdb.jp/data/gene/57582.shtml
CleanEx	HS_KCNT1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNT1
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
DOI	10.1038/ng.2440	http://dx.doi.org/10.1038/ng.2440
DOI	10.1038/ng.2441	http://dx.doi.org/10.1038/ng.2441
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/nn.2563	http://dx.doi.org/10.1038/nn.2563
DOI	10.1093/dnares/7.1.65	http://dx.doi.org/10.1093/dnares/7.1.65
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB037843	http://www.ebi.ac.uk/ena/data/view/AB037843
EMBL	AK127272	http://www.ebi.ac.uk/ena/data/view/AK127272
EMBL	AL158822	http://www.ebi.ac.uk/ena/data/view/AL158822
EMBL	BC136618	http://www.ebi.ac.uk/ena/data/view/BC136618
EMBL	BC171770	http://www.ebi.ac.uk/ena/data/view/BC171770
EMBL	CH471090	http://www.ebi.ac.uk/ena/data/view/CH471090
Ensembl	ENST00000371757	http://www.ensembl.org/id/ENST00000371757
Ensembl	ENST00000487664	http://www.ensembl.org/id/ENST00000487664
Ensembl	ENST00000488444	http://www.ensembl.org/id/ENST00000488444
Ensembl	ENST00000628528	http://www.ensembl.org/id/ENST00000628528
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0015269	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015269
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
Gene3D	3.40.50.720	http://www.cathdb.info/version/latest/superfamily/3.40.50.720
GeneCards	KCNT1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNT1
GeneID	57582	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57582
GeneTree	ENSGT00530000063026	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063026
HGNC	HGNC:18865	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18865
HOGENOM	HOG000231460	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231460&db=HOGENOM6
HOVERGEN	HBG055190	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG055190&db=HOVERGEN
HPA	HPA059880	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA059880
InParanoid	Q5JUK3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q5JUK3
InterPro	IPR003929	http://www.ebi.ac.uk/interpro/entry/IPR003929
InterPro	IPR013099	http://www.ebi.ac.uk/interpro/entry/IPR013099
InterPro	IPR016040	http://www.ebi.ac.uk/interpro/entry/IPR016040
Jabion	57582	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=57582
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:57582	http://www.genome.jp/dbget-bin/www_bget?hsa:57582
KEGG_Orthology	KO:K04946	http://www.genome.jp/dbget-bin/www_bget?KO:K04946
MIM	608167	http://www.ncbi.nlm.nih.gov/omim/608167
MIM	614959	http://www.ncbi.nlm.nih.gov/omim/614959
MIM	615005	http://www.ncbi.nlm.nih.gov/omim/615005
OMA	RTANEYH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RTANEYH
Orphanet	293181	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=293181
Orphanet	98784	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98784
OrthoDB	EOG091G011O	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G011O
PSORT	swissprot:KCNT1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNT1_HUMAN
PSORT-B	swissprot:KCNT1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNT1_HUMAN
PSORT2	swissprot:KCNT1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNT1_HUMAN
Pfam	PF03493	http://pfam.xfam.org/family/PF03493
Pfam	PF07885	http://pfam.xfam.org/family/PF07885
PharmGKB	PA38725	http://www.pharmgkb.org/do/serve?objId=PA38725&objCls=Gene
Phobius	swissprot:KCNT1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNT1_HUMAN
PhylomeDB	Q5JUK3	http://phylomedb.org/?seqid=Q5JUK3
ProteinModelPortal	Q5JUK3	http://www.proteinmodelportal.org/query/uniprot/Q5JUK3
PubMed	10718198	http://www.ncbi.nlm.nih.gov/pubmed/10718198
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	20512134	http://www.ncbi.nlm.nih.gov/pubmed/20512134
PubMed	23086396	http://www.ncbi.nlm.nih.gov/pubmed/23086396
PubMed	23086397	http://www.ncbi.nlm.nih.gov/pubmed/23086397
RefSeq	NP_001258932	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001258932
RefSeq	NP_065873	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_065873
STRING	9606.ENSP00000360822	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000360822&targetmode=cogs
UCSC	uc011mdq	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc011mdq&org=rat
UniGene	Hs.104950	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.104950
UniProtKB	KCNT1_HUMAN	http://www.uniprot.org/uniprot/KCNT1_HUMAN
UniProtKB-AC	Q5JUK3	http://www.uniprot.org/uniprot/Q5JUK3
charge	swissprot:KCNT1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNT1_HUMAN
eggNOG	ENOG410XSMA	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSMA
eggNOG	KOG3193	http://eggnogapi.embl.de/nog_data/html/tree/KOG3193
epestfind	swissprot:KCNT1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNT1_HUMAN
garnier	swissprot:KCNT1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNT1_HUMAN
helixturnhelix	swissprot:KCNT1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNT1_HUMAN
hmoment	swissprot:KCNT1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNT1_HUMAN
iep	swissprot:KCNT1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNT1_HUMAN
inforesidue	swissprot:KCNT1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNT1_HUMAN
neXtProt	NX_Q5JUK3	http://www.nextprot.org/db/entry/NX_Q5JUK3
octanol	swissprot:KCNT1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNT1_HUMAN
pepcoil	swissprot:KCNT1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNT1_HUMAN
pepdigest	swissprot:KCNT1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNT1_HUMAN
pepinfo	swissprot:KCNT1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNT1_HUMAN
pepnet	swissprot:KCNT1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNT1_HUMAN
pepstats	swissprot:KCNT1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNT1_HUMAN
pepwheel	swissprot:KCNT1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNT1_HUMAN
pepwindow	swissprot:KCNT1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNT1_HUMAN
sigcleave	swissprot:KCNT1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNT1_HUMAN
## Database	ID	URL or Descriptions
# AltName	COX7C_HUMAN	Cytochrome c oxidase polypeptide VIIc
# BioGrid	107743	2
# CDD	cd00929	Cyt_c_Oxidase_VIIc
# DrugBank	DB02659	Cholic Acid
# Ensembl	ENST00000247655	ENSP00000247655; ENSG00000127184
# Ensembl	ENST00000509578	ENSP00000425759; ENSG00000127184
# ExpressionAtlas	P15954	baseline and differential
# FUNCTION	COX7C_HUMAN	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. 
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0005751	mitochondrial respiratory chain complex IV; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0004129	cytochrome-c oxidase activity; IEA:InterPro.
# GO_process	GO:0006091	generation of precursor metabolites and energy; TAS:ProtInc.
# GO_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# Gene3D	4.10.49.10	-; 1.
# Genevisible	P15954	HS
# HGNC	HGNC:2292	COX7C
# IntAct	P15954	3
# InterPro	IPR004202	COX7C/Cox8
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	603774	gene
# Organism	COX7C_HUMAN	Homo sapiens (Human)
# PIR	S15763	OSHU7C
# Pfam	PF02935	COX7C
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-5628897	TP53 Regulates Metabolic Genes
# Reactome	R-HSA-611105	Respiratory electron transport
# RecName	COX7C_HUMAN	Cytochrome c oxidase subunit 7C, mitochondrial
# RefSeq	NP_001858	NM_001867.2
# SIMILARITY	Belongs to the cytochrome c oxidase VIIc family. {ECO	0000305}.
# SUBCELLULAR LOCATION	COX7C_HUMAN	Mitochondrion inner membrane {ECO 0000250}. 
# SUPFAM	SSF81427	SSF81427
# TCDB	3.D.4.11	the proton-translocating cytochrome oxidase (cox) superfamily
# UCSC	uc003kir	human
# eggNOG	ENOG4112B97	LUCA
# eggNOG	KOG4527	Eukaryota
BLAST	swissprot:COX7C_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:COX7C_HUMAN
BioCyc	ZFISH:HS05077-MONOMER	http://biocyc.org/getid?id=ZFISH:HS05077-MONOMER
COXPRESdb	1350	http://coxpresdb.jp/data/gene/1350.shtml
CleanEx	HS_COX7C	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_COX7C
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1093/nar/18.3.684	http://dx.doi.org/10.1093/nar/18.3.684
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1432-1033.1992.tb19847.x	http://dx.doi.org/10.1111/j.1432-1033.1992.tb19847.x
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DrugBank	DB02659	http://www.drugbank.ca/drugs/DB02659
EMBL	AF067638	http://www.ebi.ac.uk/ena/data/view/AF067638
EMBL	AF067639	http://www.ebi.ac.uk/ena/data/view/AF067639
EMBL	BC001005	http://www.ebi.ac.uk/ena/data/view/BC001005
EMBL	BC007498	http://www.ebi.ac.uk/ena/data/view/BC007498
EMBL	BT007098	http://www.ebi.ac.uk/ena/data/view/BT007098
EMBL	X16560	http://www.ebi.ac.uk/ena/data/view/X16560
Ensembl	ENST00000247655	http://www.ensembl.org/id/ENST00000247655
Ensembl	ENST00000509578	http://www.ensembl.org/id/ENST00000509578
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005751	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005751
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0004129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004129
GO_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GO_process	GO:0006123	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006123
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
Gene3D	4.10.49.10	http://www.cathdb.info/version/latest/superfamily/4.10.49.10
GeneCards	COX7C	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=COX7C
GeneID	1350	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1350
GeneTree	ENSGT00390000018086	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000018086
HGNC	HGNC:2292	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2292
HOGENOM	HOG000237276	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237276&db=HOGENOM6
HOVERGEN	HBG051093	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051093&db=HOVERGEN
HPA	HPA046647	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA046647
InParanoid	P15954	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P15954
IntAct	P15954	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P15954*
InterPro	IPR004202	http://www.ebi.ac.uk/interpro/entry/IPR004202
Jabion	1350	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1350
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Gene	hsa:1350	http://www.genome.jp/dbget-bin/www_bget?hsa:1350
KEGG_Orthology	KO:K02272	http://www.genome.jp/dbget-bin/www_bget?KO:K02272
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	603774	http://www.ncbi.nlm.nih.gov/omim/603774
OMA	VRHQILK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VRHQILK
OrthoDB	EOG091G16OJ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G16OJ
PSORT	swissprot:COX7C_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:COX7C_HUMAN
PSORT-B	swissprot:COX7C_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:COX7C_HUMAN
PSORT2	swissprot:COX7C_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:COX7C_HUMAN
Pfam	PF02935	http://pfam.xfam.org/family/PF02935
PharmGKB	PA26812	http://www.pharmgkb.org/do/serve?objId=PA26812&objCls=Gene
Phobius	swissprot:COX7C_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:COX7C_HUMAN
PhylomeDB	P15954	http://phylomedb.org/?seqid=P15954
ProteinModelPortal	P15954	http://www.proteinmodelportal.org/query/uniprot/P15954
PubMed	10072584	http://www.ncbi.nlm.nih.gov/pubmed/10072584
PubMed	1309697	http://www.ncbi.nlm.nih.gov/pubmed/1309697
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	2155413	http://www.ncbi.nlm.nih.gov/pubmed/2155413
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-5628897	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5628897
Reactome	R-HSA-611105	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-611105
RefSeq	NP_001858	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001858
SMR	P15954	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P15954
STRING	9606.ENSP00000247655	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000247655&targetmode=cogs
SUPFAM	SSF81427	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81427
TCDB	3.D.4.11	http://www.tcdb.org/search/result.php?tc=3.D.4.11
UCSC	uc003kir	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003kir&org=rat
UniGene	Hs.430075	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.430075
UniProtKB	COX7C_HUMAN	http://www.uniprot.org/uniprot/COX7C_HUMAN
UniProtKB-AC	P15954	http://www.uniprot.org/uniprot/P15954
charge	swissprot:COX7C_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:COX7C_HUMAN
eggNOG	ENOG4112B97	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4112B97
eggNOG	KOG4527	http://eggnogapi.embl.de/nog_data/html/tree/KOG4527
epestfind	swissprot:COX7C_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:COX7C_HUMAN
garnier	swissprot:COX7C_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:COX7C_HUMAN
helixturnhelix	swissprot:COX7C_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:COX7C_HUMAN
hmoment	swissprot:COX7C_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:COX7C_HUMAN
iep	swissprot:COX7C_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:COX7C_HUMAN
inforesidue	swissprot:COX7C_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:COX7C_HUMAN
neXtProt	NX_P15954	http://www.nextprot.org/db/entry/NX_P15954
octanol	swissprot:COX7C_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:COX7C_HUMAN
pepcoil	swissprot:COX7C_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:COX7C_HUMAN
pepdigest	swissprot:COX7C_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:COX7C_HUMAN
pepinfo	swissprot:COX7C_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:COX7C_HUMAN
pepnet	swissprot:COX7C_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:COX7C_HUMAN
pepstats	swissprot:COX7C_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:COX7C_HUMAN
pepwheel	swissprot:COX7C_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:COX7C_HUMAN
pepwindow	swissprot:COX7C_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:COX7C_HUMAN
sigcleave	swissprot:COX7C_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:COX7C_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TRPM8_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q7Z2W7-1; Sequence=Displayed; Name=2; Synonyms=sTRPM8-18, sM8-18; IsoId=Q7Z2W7-2; Sequence=VSP_053268, VSP_012332, VSP_012333; Name=3; Synonyms=sTRPM8-6, sM8-6; IsoId=Q7Z2W7-3; Sequence=VSP_012330, VSP_012332, VSP_012333; Name=4; IsoId=Q7Z2W7-4; Sequence=VSP_054505, VSP_054506, VSP_054507; Note=No experimental confirmation available.; 
# AltName	TRPM8_HUMAN	Long transient receptor potential channel 6
# AltName	TRPM8_HUMAN	Transient receptor potential p8
# BioGrid	122512	11
# CAUTION	The 192-residue sequence submitted as AAS45276 has been confirmed by the authors of PubMed:22128173 to be incorrect as translation starts from a downstream methionine. {ECO	0000305}. 
# CCDS	CCDS33407	-. [Q7Z2W7-1]
# DOMAIN	TRPM8_HUMAN	The coiled coil region is required for multimerization. {ECO 0000269|PubMed 17065148, ECO 0000269|PubMed 25559186}. 
# DrugBank	DB00825	Menthol
# Ensembl	ENST00000324695	ENSP00000323926; ENSG00000144481. [Q7Z2W7-1]
# Ensembl	ENST00000409625	ENSP00000386771; ENSG00000144481. [Q7Z2W7-3]
# ExpressionAtlas	Q7Z2W7	baseline and differential
# FUNCTION	TRPM8_HUMAN	Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration (PubMed 25559186). Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel. {ECO 0000269|PubMed 15306801, ECO 0000269|PubMed 16174775, ECO 0000269|PubMed 22128173, ECO 0000269|PubMed 25559186}. 
# GO_component	GO:0005789	endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; IDA:MGI.
# GO_component	GO:0009897	external side of plasma membrane; IEA:Ensembl.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0045121	membrane raft; IEA:UniProtKB-SubCell.
# GO_function	GO:0005262	calcium channel activity; TAS:Reactome.
# GO_process	GO:0006874	cellular calcium ion homeostasis; IEA:Ensembl.
# GO_process	GO:0009409	response to cold; IEA:Ensembl.
# GO_process	GO:0016048	detection of temperature stimulus; IEA:InterPro.
# GO_process	GO:0050955	thermoception; IEA:Ensembl.
# GO_process	GO:0051289	protein homotetramerization; IEA:Ensembl.
# GO_process	GO:0070207	protein homotrimerization; IEA:Ensembl.
# GO_process	GO:0070588	calcium ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q7Z2W7	HS
# HGNC	HGNC:17961	TRPM8
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR029603	TRPM8
# KEGG_Brite	ko04040	Ion channels
# MIM	606678	gene
# MISCELLANEOUS	TRPM8_HUMAN	Its expression in most prostate tumors as well as the presence of an immunogenic epitope suggest that it may be suitable for the design of peptide vaccination strategies for prostate cancers. 
# MISCELLANEOUS	TRPM8_HUMAN	The sensation of coolness triggered by eucalyptol or menthol may be explained by the fact that menthol and cool temperatures sensations are detected by this protein. 
# Organism	TRPM8_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR13800:SF9	PTHR13800:SF9
# Pfam	PF00520	Ion_trans
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-3295583	TRP channels
# RecName	TRPM8_HUMAN	Transient receptor potential cation channel subfamily M member 8
# RefSeq	NP_076985	NM_024080.4. [Q7Z2W7-1]
# SEQUENCE CAUTION	Sequence=AAH01135.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAS45276.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM8 sub-subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	TRPM8_HUMAN	Cell membrane; Multi-pass membrane protein. Membrane raft. Endoplasmic reticulum membrane. Note=Localizes to membrane rafts but is also located in the cell membrane outside of these regions where channel response to cold is enhanced compared to membrane rafts (By similarity). Located in the endoplasmic reticulum in prostate cancer cells. {ECO 0000250}. 
# SUBUNIT	TRPM8_HUMAN	Homotetramer (By similarity). Isoform 2 and isoform 3 interact with the C-terminus of isoform 1 in a thermosensitive manner with decreased interaction at 21 degrees Celsius compared to 37 degrees Celsius. Interacts (via N-terminus and C-terminus domains) with TCAF1; the interaction stimulates TRPM8 channel activity (PubMed 25559186). Interacts (via N-terminus and C- terminus domains) with TCAF2 isoform 2; the interaction inhibits TRPM8 channel activity (PubMed 25559186). {ECO 0000250, ECO 0000269|PubMed 22128173, ECO 0000269|PubMed 25559186}. 
# TCDB	1.A.4.5	the transient receptor potential ca(2+) channel (trp-cc) family
# TISSUE SPECIFICITY	TRPM8_HUMAN	Expressed in prostate. Also expressed in prostate tumors and in non-prostatic primary tumors such as colon, lung, breast and skin tumors. {ECO 0000269|PubMed 11325849, ECO 0000269|PubMed 12858355, ECO 0000269|PubMed 16174775, ECO 0000269|PubMed 22128173}. 
# UCSC	uc002vvi	human. [Q7Z2W7-1]
# eggNOG	ENOG410INBX	Eukaryota
# eggNOG	ENOG4110YBY	LUCA
BLAST	swissprot:TRPM8_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TRPM8_HUMAN
COXPRESdb	79054	http://coxpresdb.jp/data/gene/79054.shtml
CleanEx	HS_TRPM8	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TRPM8
DOI	10.1002/pros.10265	http://dx.doi.org/10.1002/pros.10265
DOI	10.1038/nature02732	http://dx.doi.org/10.1038/nature02732
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1074/jbc.M111.270256	http://dx.doi.org/10.1074/jbc.M111.270256
DOI	10.1074/jbc.M503544200	http://dx.doi.org/10.1074/jbc.M503544200
DOI	10.1074/jbc.M607756200	http://dx.doi.org/10.1074/jbc.M607756200
DOI	10.1083/jcb.201402076	http://dx.doi.org/10.1083/jcb.201402076
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00825	http://www.drugbank.ca/drugs/DB00825
EMBL	AB061779	http://www.ebi.ac.uk/ena/data/view/AB061779
EMBL	AC005538	http://www.ebi.ac.uk/ena/data/view/AC005538
EMBL	AY090109	http://www.ebi.ac.uk/ena/data/view/AY090109
EMBL	AY328400	http://www.ebi.ac.uk/ena/data/view/AY328400
EMBL	AY532375	http://www.ebi.ac.uk/ena/data/view/AY532375
EMBL	AY532376	http://www.ebi.ac.uk/ena/data/view/AY532376
EMBL	BC001135	http://www.ebi.ac.uk/ena/data/view/BC001135
EMBL	BC126342	http://www.ebi.ac.uk/ena/data/view/BC126342
EMBL	CH471063	http://www.ebi.ac.uk/ena/data/view/CH471063
EMBL	DQ139309	http://www.ebi.ac.uk/ena/data/view/DQ139309
Ensembl	ENST00000324695	http://www.ensembl.org/id/ENST00000324695
Ensembl	ENST00000409625	http://www.ensembl.org/id/ENST00000409625
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0009897	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009897
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0045121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045121
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_process	GO:0006874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874
GO_process	GO:0009409	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009409
GO_process	GO:0016048	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016048
GO_process	GO:0050955	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050955
GO_process	GO:0051289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051289
GO_process	GO:0070207	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070207
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	TRPM8	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TRPM8
GeneID	79054	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79054
GeneTree	ENSGT00760000119127	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119127
HGNC	HGNC:17961	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17961
HOGENOM	HOG000236350	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236350&db=HOGENOM6
HOVERGEN	HBG100888	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG100888&db=HOVERGEN
InParanoid	Q7Z2W7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q7Z2W7
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR029603	http://www.ebi.ac.uk/interpro/entry/IPR029603
Jabion	79054	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=79054
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:79054	http://www.genome.jp/dbget-bin/www_bget?hsa:79054
KEGG_Orthology	KO:K04983	http://www.genome.jp/dbget-bin/www_bget?KO:K04983
MIM	606678	http://www.ncbi.nlm.nih.gov/omim/606678
OMA	YIMDDFT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YIMDDFT
OrthoDB	EOG091G035A	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G035A
PANTHER	PTHR13800:SF9	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13800:SF9
PSORT	swissprot:TRPM8_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TRPM8_HUMAN
PSORT-B	swissprot:TRPM8_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TRPM8_HUMAN
PSORT2	swissprot:TRPM8_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TRPM8_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
PharmGKB	PA38270	http://www.pharmgkb.org/do/serve?objId=PA38270&objCls=Gene
Phobius	swissprot:TRPM8_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TRPM8_HUMAN
PhylomeDB	Q7Z2W7	http://phylomedb.org/?seqid=Q7Z2W7
ProteinModelPortal	Q7Z2W7	http://www.proteinmodelportal.org/query/uniprot/Q7Z2W7
PubMed	11325849	http://www.ncbi.nlm.nih.gov/pubmed/11325849
PubMed	12858355	http://www.ncbi.nlm.nih.gov/pubmed/12858355
PubMed	15306801	http://www.ncbi.nlm.nih.gov/pubmed/15306801
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	16174775	http://www.ncbi.nlm.nih.gov/pubmed/16174775
PubMed	17065148	http://www.ncbi.nlm.nih.gov/pubmed/17065148
PubMed	22128173	http://www.ncbi.nlm.nih.gov/pubmed/22128173
PubMed	25559186	http://www.ncbi.nlm.nih.gov/pubmed/25559186
Reactome	R-HSA-3295583	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3295583
RefSeq	NP_076985	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_076985
STRING	9606.ENSP00000323926	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000323926&targetmode=cogs
TCDB	1.A.4.5	http://www.tcdb.org/search/result.php?tc=1.A.4.5
UCSC	uc002vvi	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002vvi&org=rat
UniGene	Hs.366053	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.366053
UniProtKB	TRPM8_HUMAN	http://www.uniprot.org/uniprot/TRPM8_HUMAN
UniProtKB-AC	Q7Z2W7	http://www.uniprot.org/uniprot/Q7Z2W7
charge	swissprot:TRPM8_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TRPM8_HUMAN
eggNOG	ENOG410INBX	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410INBX
eggNOG	ENOG4110YBY	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110YBY
epestfind	swissprot:TRPM8_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TRPM8_HUMAN
garnier	swissprot:TRPM8_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TRPM8_HUMAN
helixturnhelix	swissprot:TRPM8_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRPM8_HUMAN
hmoment	swissprot:TRPM8_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TRPM8_HUMAN
iep	swissprot:TRPM8_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TRPM8_HUMAN
inforesidue	swissprot:TRPM8_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TRPM8_HUMAN
neXtProt	NX_Q7Z2W7	http://www.nextprot.org/db/entry/NX_Q7Z2W7
octanol	swissprot:TRPM8_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TRPM8_HUMAN
pepcoil	swissprot:TRPM8_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TRPM8_HUMAN
pepdigest	swissprot:TRPM8_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TRPM8_HUMAN
pepinfo	swissprot:TRPM8_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TRPM8_HUMAN
pepnet	swissprot:TRPM8_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TRPM8_HUMAN
pepstats	swissprot:TRPM8_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TRPM8_HUMAN
pepwheel	swissprot:TRPM8_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TRPM8_HUMAN
pepwindow	swissprot:TRPM8_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TRPM8_HUMAN
sigcleave	swissprot:TRPM8_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TRPM8_HUMAN
## Database	ID	URL or Descriptions
# AltName	TFR1_HUMAN	CD71
# AltName	TFR1_HUMAN	CD71
# AltName	TFR1_HUMAN	T9
# AltName	TFR1_HUMAN	p90
# BioGrid	112895	82
# ChiTaRS	TFRC	human
# DISEASE	TFR1_HUMAN	Immunodeficiency 46 (IMD46) [MIM 616740]  An autosomal recessive primary immunodeficiency disorder characterized by early-onset chronic diarrhea, recurrent infections, hypo- or agammaglobulinemia, normal lymphocyte counts, intermittent neutropenia, and intermittent thrombocytopenia. {ECO 0000269|PubMed 26642240}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB05260	Gallium nitrate
# Ensembl	ENST00000360110	ENSP00000353224; ENSG00000072274
# Ensembl	ENST00000392396	ENSP00000376197; ENSG00000072274
# ExpressionAtlas	P02786	baseline and differential
# FUNCTION	TFR1_HUMAN	(Microbial infection) Acts as a receptor for new-world arenaviruses  Guanarito, Junin and Machupo virus. {ECO 0000269|PubMed 17287727, ECO 0000269|PubMed 18268337}. 
# FUNCTION	TFR1_HUMAN	Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed 26642240). {ECO 0000250, ECO 0000269|PubMed 26642240, ECO 0000269|PubMed 3568132}. 
# GO_component	GO:0005576	extracellular region; IDA:UniProtKB.
# GO_component	GO:0005615	extracellular space; IDA:UniProtKB.
# GO_component	GO:0005768	endosome; IDA:MGI.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IGI:BHF-UCL.
# GO_component	GO:0005905	clathrin-coated pit; IDA:UniProtKB.
# GO_component	GO:0009897	external side of plasma membrane; IGI:BHF-UCL.
# GO_component	GO:0009986	cell surface; IDA:UniProtKB.
# GO_component	GO:0016020	membrane; NAS:UniProtKB.
# GO_component	GO:0016023	cytoplasmic, membrane-bounded vesicle; IDA:MGI.
# GO_component	GO:0016323	basolateral plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0042470	melanosome; IEA:UniProtKB-SubCell.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IDA:CACAO.
# GO_component	GO:0055037	recycling endosome; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_component	GO:0072562	blood microparticle; IDA:UniProtKB.
# GO_component	GO:1903561	extracellular vesicle; IDA:UniProtKB.
# GO_component	GO:1990712	HFE-transferrin receptor complex; IDA:BHF-UCL.
# GO_function	GO:0001618	virus receptor activity; IEA:UniProtKB-KW.
# GO_function	GO:0001948	glycoprotein binding; IPI:BHF-UCL.
# GO_function	GO:0003725	double-stranded RNA binding; IDA:MGI.
# GO_function	GO:0004998	transferrin receptor activity; NAS:UniProtKB.
# GO_function	GO:0033570	transferrin transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0042803	protein homodimerization activity; IPI:BHF-UCL.
# GO_function	GO:0044822	poly(A) RNA binding; IDA:UniProtKB.
# GO_process	GO:0006879	cellular iron ion homeostasis; NAS:UniProtKB.
# GO_process	GO:0030316	osteoclast differentiation; IEA:Ensembl.
# GO_process	GO:0030890	positive regulation of B cell proliferation; IDA:UniProtKB.
# GO_process	GO:0031623	receptor internalization; IDA:UniProtKB.
# GO_process	GO:0033572	transferrin transport; IDA:UniProtKB.
# GO_process	GO:0035690	cellular response to drug; IDA:MGI.
# GO_process	GO:0042102	positive regulation of T cell proliferation; IDA:UniProtKB.
# GO_process	GO:0045780	positive regulation of bone resorption; IEA:Ensembl.
# GO_process	GO:0045830	positive regulation of isotype switching; IDA:UniProtKB.
# GO_process	GO:0097286	iron ion import; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005576	extracellular region
# GOslim_component	GO:0005615	extracellular space
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0003723	RNA binding
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0042592	homeostatic process
# Gene3D	1.20.930.40	-; 1.
# Genevisible	P02786	HS
# HGNC	HGNC:11763	TFRC
# INDUCTION	TFR1_HUMAN	Regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation. 
# INTERACTION	TFR1_HUMAN	Self; NbExp=2; IntAct=EBI-355727, EBI-355727; P02768 ALB; NbExp=2; IntAct=EBI-355727, EBI-714423; Q30201 HFE; NbExp=3; IntAct=EBI-355727, EBI-1028850; O43765 SGTA; NbExp=3; IntAct=EBI-355727, EBI-347996; Q9P0V3 SH3BP4; NbExp=6; IntAct=EBI-355727, EBI-1049513; 
# IntAct	P02786	58
# InterPro	IPR003137	PA_domain
# InterPro	IPR007365	TFR-like_dimer_dom
# InterPro	IPR007484	Peptidase_M28
# InterPro	IPR029513	TfR
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04090	 Cellular antigens
# KEGG_Pathway	ko04066	HIF-1 signaling pathway
# KEGG_Pathway	ko04144	Endocytosis
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko04640	Hematopoietic cell lineage
# MIM	190010	gene
# MIM	616740	phenotype
# MISCELLANEOUS	TFR1_HUMAN	Canine and feline parvoviruses bind human and feline transferrin receptors and use these receptors to enter and infect cells. 
# MISCELLANEOUS	TFR1_HUMAN	Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemia resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients. 
# Organism	TFR1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10404:SF26	PTHR10404:SF26
# PDB	1CX8	X-ray; 3.20 A; A/B/C/D/E/F/G/H=122-760
# PDB	1DE4	X-ray; 2.80 A; C/F/I=121-760
# PDB	1SUV	EM; 7.50 A; A/B=122-760
# PDB	2NSU	EM; 27.00 A; A/B=122-760
# PDB	3KAS	X-ray; 2.40 A; A=121-760
# PDB	3S9L	X-ray; 3.22 A; A/B=120-760
# PDB	3S9M	X-ray; 3.32 A; A/B=120-760
# PDB	3S9N	X-ray; 3.25 A; A/B=120-760
# PIR	A93343	JXHU
# PTM	TFR1_HUMAN	N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated. {ECO 0000269|PubMed 1421756, ECO 0000269|PubMed 1421757, ECO 0000269|PubMed 16335952, ECO 0000269|PubMed 19159218, ECO 0000269|PubMed 19349973, ECO 0000269|PubMed 3582362}. 
# PTM	TFR1_HUMAN	Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation. {ECO 0000269|PubMed 3582362}. 
# PTM	TFR1_HUMAN	Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR). 
# Pfam	PF02225	PA
# Pfam	PF04253	TFR_dimer
# Pfam	PF04389	Peptidase_M28
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-432722	Golgi Associated Vesicle Biogenesis
# Reactome	R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis
# Reactome	R-HSA-8856828	Clathrin-mediated endocytosis
# Reactome	R-HSA-917977	Transferrin endocytosis and recycling
# RecName	TFR1_HUMAN	Transferrin receptor protein 1
# RecName	TFR1_HUMAN	Transferrin receptor protein 1, serum form
# RefSeq	NP_001121620	NM_001128148.2
# RefSeq	NP_001300894	NM_001313965.1
# RefSeq	NP_001300895	NM_001313966.1
# RefSeq	NP_003225	NM_003234.3
# SEQUENCE CAUTION	Sequence=BAD92491.1; Type=Erroneous initiation; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the peptidase M28 family. M28B subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 PA (protease associated) domain. {ECO	0000305}. 
# SUBCELLULAR LOCATION	TFR1_HUMAN	Cell membrane {ECO 0000269|PubMed 17081065}; Single-pass type II membrane protein {ECO 0000269|PubMed 17081065}. Melanosome {ECO 0000269|PubMed 17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO 0000269|PubMed 17081065}. 
# SUBCELLULAR LOCATION	TFR1_HUMAN	Transferrin receptor protein 1, serum form  Secreted {ECO 0000269|PubMed 17081065}. 
# SUBUNIT	TFR1_HUMAN	(Microbial infection) Interacts with Guanarito, Junin and Machupo arenavirus glycoprotein complex (PubMed 17287727, PubMed 18268337). {ECO 0000269|PubMed 17287727, ECO 0000269|PubMed 18268337}. 
# SUBUNIT	TFR1_HUMAN	Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Binds the HLA class II histocompatibility antigen, DR1. Interacts with SH3BP3. Interacts with STEAP3; facilitates TFRC endocytosis in erythroid precursor cells (PubMed 26642240). {ECO 0000269|PubMed 16325581, ECO 0000269|PubMed 26642240}. 
# SUPFAM	SSF47672	SSF47672
# UCSC	uc003fvz	human
# WEB RESOURCE	TFR1_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/TFRCID259ch3q29.html";
# eggNOG	COG2234	LUCA
# eggNOG	KOG2195	Eukaryota
BLAST	swissprot:TFR1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TFR1_HUMAN
BioCyc	ZFISH:ENSG00000072274-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000072274-MONOMER
COXPRESdb	7037	http://coxpresdb.jp/data/gene/7037.shtml
CleanEx	HS_TFRC	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TFRC
DIP	DIP-2736N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-2736N
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/jmbi.2001.5048	http://dx.doi.org/10.1006/jmbi.2001.5048
DOI	10.1007/s004390100599	http://dx.doi.org/10.1007/s004390100599
DOI	10.1016/0092-8674(84)90004-7	http://dx.doi.org/10.1016/0092-8674(84)90004-7
DOI	10.1016/0092-8674(87)90295-9	http://dx.doi.org/10.1016/0092-8674(87)90295-9
DOI	10.1016/S0378-1119(97)00356-9	http://dx.doi.org/10.1016/S0378-1119(97)00356-9
DOI	10.1016/S0969-2126(98)00124-5	http://dx.doi.org/10.1016/S0969-2126(98)00124-5
DOI	10.1016/j.cell.2005.10.021	http://dx.doi.org/10.1016/j.cell.2005.10.021
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr0502065	http://dx.doi.org/10.1021/pr0502065
DOI	10.1021/pr060363j	http://dx.doi.org/10.1021/pr060363j
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/311675b0	http://dx.doi.org/10.1038/311675b0
DOI	10.1038/358764a0	http://dx.doi.org/10.1038/358764a0
DOI	10.1038/nature05539	http://dx.doi.org/10.1038/nature05539
DOI	10.1038/nbt.1532	http://dx.doi.org/10.1038/nbt.1532
DOI	10.1038/nbt1046	http://dx.doi.org/10.1038/nbt1046
DOI	10.1038/ng.3465	http://dx.doi.org/10.1038/ng.3465
DOI	10.1042/bj2670031	http://dx.doi.org/10.1042/bj2670031
DOI	10.1042/bj3060129	http://dx.doi.org/10.1042/bj3060129
DOI	10.1042/bj3410011	http://dx.doi.org/10.1042/bj3410011
DOI	10.1073/pnas.0709254105	http://dx.doi.org/10.1073/pnas.0709254105
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1083/jcb.110.2.283	http://dx.doi.org/10.1083/jcb.110.2.283
DOI	10.1093/glycob/2.4.345	http://dx.doi.org/10.1093/glycob/2.4.345
DOI	10.1093/glycob/2.4.355	http://dx.doi.org/10.1093/glycob/2.4.355
DOI	10.1093/glycob/5.2.227	http://dx.doi.org/10.1093/glycob/5.2.227
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1432-1033.1996.0009u.x	http://dx.doi.org/10.1111/j.1432-1033.1996.0009u.x
DOI	10.1126/science.286.5440.779	http://dx.doi.org/10.1126/science.286.5440.779
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.3181/00379727-197-43276	http://dx.doi.org/10.3181/00379727-197-43276
DrugBank	DB05260	http://www.drugbank.ca/drugs/DB05260
EMBL	AB209254	http://www.ebi.ac.uk/ena/data/view/AB209254
EMBL	AF187320	http://www.ebi.ac.uk/ena/data/view/AF187320
EMBL	BC001188	http://www.ebi.ac.uk/ena/data/view/BC001188
EMBL	CH471191	http://www.ebi.ac.uk/ena/data/view/CH471191
EMBL	CH471191	http://www.ebi.ac.uk/ena/data/view/CH471191
EMBL	DQ496099	http://www.ebi.ac.uk/ena/data/view/DQ496099
EMBL	M11507	http://www.ebi.ac.uk/ena/data/view/M11507
EMBL	X01060	http://www.ebi.ac.uk/ena/data/view/X01060
Ensembl	ENST00000360110	http://www.ensembl.org/id/ENST00000360110
Ensembl	ENST00000392396	http://www.ensembl.org/id/ENST00000392396
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005576	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576
GO_component	GO:0005615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005615
GO_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005905	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005905
GO_component	GO:0009897	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009897
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016023	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016023
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0042470	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042470
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_component	GO:0055037	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055037
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_component	GO:0072562	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072562
GO_component	GO:1903561	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903561
GO_component	GO:1990712	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990712
GO_function	GO:0001618	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001618
GO_function	GO:0001948	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001948
GO_function	GO:0003725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003725
GO_function	GO:0004998	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004998
GO_function	GO:0033570	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033570
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_function	GO:0044822	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044822
GO_process	GO:0006879	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006879
GO_process	GO:0030316	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030316
GO_process	GO:0030890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030890
GO_process	GO:0031623	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031623
GO_process	GO:0033572	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033572
GO_process	GO:0035690	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035690
GO_process	GO:0042102	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042102
GO_process	GO:0045780	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045780
GO_process	GO:0045830	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045830
GO_process	GO:0097286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097286
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005576	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576
GOslim_component	GO:0005615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005615
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0003723	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
Gene3D	1.20.930.40	http://www.cathdb.info/version/latest/superfamily/1.20.930.40
GeneCards	TFRC	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TFRC
GeneID	7037	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7037
GeneTree	ENSGT00550000074421	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074421
HGNC	HGNC:11763	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11763
HOVERGEN	HBG023177	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG023177&db=HOVERGEN
HPA	CAB000153	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB000153
HPA	HPA028598	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA028598
InParanoid	P02786	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P02786
IntAct	P02786	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P02786*
InterPro	IPR003137	http://www.ebi.ac.uk/interpro/entry/IPR003137
InterPro	IPR007365	http://www.ebi.ac.uk/interpro/entry/IPR007365
InterPro	IPR007484	http://www.ebi.ac.uk/interpro/entry/IPR007484
InterPro	IPR029513	http://www.ebi.ac.uk/interpro/entry/IPR029513
Jabion	7037	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7037
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04090	http://www.genome.jp/dbget-bin/www_bget?ko04090
KEGG_Gene	hsa:7037	http://www.genome.jp/dbget-bin/www_bget?hsa:7037
KEGG_Orthology	KO:K06503	http://www.genome.jp/dbget-bin/www_bget?KO:K06503
KEGG_Pathway	ko04066	http://www.genome.jp/kegg-bin/show_pathway?ko04066
KEGG_Pathway	ko04144	http://www.genome.jp/kegg-bin/show_pathway?ko04144
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko04640	http://www.genome.jp/kegg-bin/show_pathway?ko04640
MIM	190010	http://www.ncbi.nlm.nih.gov/omim/190010
MIM	616740	http://www.ncbi.nlm.nih.gov/omim/616740
MINT	MINT-4999032	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4999032
OMA	DNSHVEM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DNSHVEM
OrthoDB	EOG091G02ZM	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02ZM
PANTHER	PTHR10404:SF26	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10404:SF26
PDB	1CX8	http://www.ebi.ac.uk/pdbe-srv/view/entry/1CX8
PDB	1DE4	http://www.ebi.ac.uk/pdbe-srv/view/entry/1DE4
PDB	1SUV	http://www.ebi.ac.uk/pdbe-srv/view/entry/1SUV
PDB	2NSU	http://www.ebi.ac.uk/pdbe-srv/view/entry/2NSU
PDB	3KAS	http://www.ebi.ac.uk/pdbe-srv/view/entry/3KAS
PDB	3S9L	http://www.ebi.ac.uk/pdbe-srv/view/entry/3S9L
PDB	3S9M	http://www.ebi.ac.uk/pdbe-srv/view/entry/3S9M
PDB	3S9N	http://www.ebi.ac.uk/pdbe-srv/view/entry/3S9N
PDBsum	1CX8	http://www.ebi.ac.uk/pdbsum/1CX8
PDBsum	1DE4	http://www.ebi.ac.uk/pdbsum/1DE4
PDBsum	1SUV	http://www.ebi.ac.uk/pdbsum/1SUV
PDBsum	2NSU	http://www.ebi.ac.uk/pdbsum/2NSU
PDBsum	3KAS	http://www.ebi.ac.uk/pdbsum/3KAS
PDBsum	3S9L	http://www.ebi.ac.uk/pdbsum/3S9L
PDBsum	3S9M	http://www.ebi.ac.uk/pdbsum/3S9M
PDBsum	3S9N	http://www.ebi.ac.uk/pdbsum/3S9N
PSORT	swissprot:TFR1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TFR1_HUMAN
PSORT-B	swissprot:TFR1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TFR1_HUMAN
PSORT2	swissprot:TFR1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TFR1_HUMAN
Pfam	PF02225	http://pfam.xfam.org/family/PF02225
Pfam	PF04253	http://pfam.xfam.org/family/PF04253
Pfam	PF04389	http://pfam.xfam.org/family/PF04389
PharmGKB	PA36478	http://www.pharmgkb.org/do/serve?objId=PA36478&objCls=Gene
Phobius	swissprot:TFR1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TFR1_HUMAN
PhylomeDB	P02786	http://phylomedb.org/?seqid=P02786
ProteinModelPortal	P02786	http://www.proteinmodelportal.org/query/uniprot/P02786
PubMed	10377239	http://www.ncbi.nlm.nih.gov/pubmed/10377239
PubMed	10531064	http://www.ncbi.nlm.nih.gov/pubmed/10531064
PubMed	11702220	http://www.ncbi.nlm.nih.gov/pubmed/11702220
PubMed	11800564	http://www.ncbi.nlm.nih.gov/pubmed/11800564
PubMed	1380674	http://www.ncbi.nlm.nih.gov/pubmed/1380674
PubMed	1421756	http://www.ncbi.nlm.nih.gov/pubmed/1421756
PubMed	1421757	http://www.ncbi.nlm.nih.gov/pubmed/1421757
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15592455	http://www.ncbi.nlm.nih.gov/pubmed/15592455
PubMed	16325581	http://www.ncbi.nlm.nih.gov/pubmed/16325581
PubMed	16335952	http://www.ncbi.nlm.nih.gov/pubmed/16335952
PubMed	17081065	http://www.ncbi.nlm.nih.gov/pubmed/17081065
PubMed	17287727	http://www.ncbi.nlm.nih.gov/pubmed/17287727
PubMed	18268337	http://www.ncbi.nlm.nih.gov/pubmed/18268337
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	1871153	http://www.ncbi.nlm.nih.gov/pubmed/1871153
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	19349973	http://www.ncbi.nlm.nih.gov/pubmed/19349973
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	2229063	http://www.ncbi.nlm.nih.gov/pubmed/2229063
PubMed	2298808	http://www.ncbi.nlm.nih.gov/pubmed/2298808
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	2327986	http://www.ncbi.nlm.nih.gov/pubmed/2327986
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	2507316	http://www.ncbi.nlm.nih.gov/pubmed/2507316
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	26642240	http://www.ncbi.nlm.nih.gov/pubmed/26642240
PubMed	3568132	http://www.ncbi.nlm.nih.gov/pubmed/3568132
PubMed	3582362	http://www.ncbi.nlm.nih.gov/pubmed/3582362
PubMed	6090955	http://www.ncbi.nlm.nih.gov/pubmed/6090955
PubMed	6094009	http://www.ncbi.nlm.nih.gov/pubmed/6094009
PubMed	7780197	http://www.ncbi.nlm.nih.gov/pubmed/7780197
PubMed	7864799	http://www.ncbi.nlm.nih.gov/pubmed/7864799
PubMed	8408022	http://www.ncbi.nlm.nih.gov/pubmed/8408022
PubMed	8631371	http://www.ncbi.nlm.nih.gov/pubmed/8631371
PubMed	9358047	http://www.ncbi.nlm.nih.gov/pubmed/9358047
PubMed	9782058	http://www.ncbi.nlm.nih.gov/pubmed/9782058
Reactome	R-HSA-432722	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432722
Reactome	R-HSA-8856825	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8856825
Reactome	R-HSA-8856828	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8856828
Reactome	R-HSA-917977	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917977
RefSeq	NP_001121620	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001121620
RefSeq	NP_001300894	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001300894
RefSeq	NP_001300895	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001300895
RefSeq	NP_003225	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003225
SMR	P02786	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P02786
STRING	9606.ENSP00000353224	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000353224&targetmode=cogs
SUPFAM	SSF47672	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47672
UCSC	uc003fvz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003fvz&org=rat
UniGene	Hs.529618	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.529618
UniProtKB	TFR1_HUMAN	http://www.uniprot.org/uniprot/TFR1_HUMAN
UniProtKB-AC	P02786	http://www.uniprot.org/uniprot/P02786
charge	swissprot:TFR1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TFR1_HUMAN
eggNOG	COG2234	http://eggnogapi.embl.de/nog_data/html/tree/COG2234
eggNOG	KOG2195	http://eggnogapi.embl.de/nog_data/html/tree/KOG2195
epestfind	swissprot:TFR1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TFR1_HUMAN
garnier	swissprot:TFR1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TFR1_HUMAN
helixturnhelix	swissprot:TFR1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TFR1_HUMAN
hmoment	swissprot:TFR1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TFR1_HUMAN
iep	swissprot:TFR1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TFR1_HUMAN
inforesidue	swissprot:TFR1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TFR1_HUMAN
neXtProt	NX_P02786	http://www.nextprot.org/db/entry/NX_P02786
octanol	swissprot:TFR1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TFR1_HUMAN
pepcoil	swissprot:TFR1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TFR1_HUMAN
pepdigest	swissprot:TFR1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TFR1_HUMAN
pepinfo	swissprot:TFR1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TFR1_HUMAN
pepnet	swissprot:TFR1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TFR1_HUMAN
pepstats	swissprot:TFR1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TFR1_HUMAN
pepwheel	swissprot:TFR1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TFR1_HUMAN
pepwindow	swissprot:TFR1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TFR1_HUMAN
sigcleave	swissprot:TFR1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TFR1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	JPH2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BR39-1; Sequence=Displayed; Name=2; IsoId=Q9BR39-2; Sequence=VSP_002785, VSP_002786; Note=No experimental confirmation available.; 
# AltName	JPH2_HUMAN	Junctophilin type 2
# CCDS	CCDS13325	-. [Q9BR39-1]
# CCDS	CCDS13326	-. [Q9BR39-2]
# ChiTaRS	JPH2	human
# DISEASE	JPH2_HUMAN	Cardiomyopathy, familial hypertrophic 17 (CMH17) [MIM 613873]  A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. {ECO 0000269|PubMed 17509612}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	JPH2_HUMAN	The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, by interacting with phospholipids. Has affinity for phosphatidylserine, and phosphorylated phosphatidylinositols including PtdIns3P, PtdIns4P, PtdIns5P, PtdIns(3,5)P2 and PtdIns(3,4,5)P3. {ECO 0000269|PubMed 24001019}. 
# Ensembl	ENST00000342272	ENSP00000344590; ENSG00000149596. [Q9BR39-2]
# Ensembl	ENST00000372980	ENSP00000362071; ENSG00000149596. [Q9BR39-1]
# FUNCTION	JPH2_HUMAN	Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH2 is necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release. Contributes to the construction of skeletal muscle triad junctions. {ECO 0000269|PubMed 20095964}. 
# GO_component	GO:0005886	plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0014701	junctional sarcoplasmic reticulum membrane; TAS:BHF-UCL.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0030018	Z disc; IEA:Ensembl.
# GO_component	GO:0030314	junctional membrane complex; IEA:Ensembl.
# GO_function	GO:0001786	phosphatidylserine binding; IDA:UniProtKB.
# GO_function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding; IDA:UniProtKB.
# GO_function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding; IDA:UniProtKB.
# GO_function	GO:0010314	phosphatidylinositol-5-phosphate binding; IDA:UniProtKB.
# GO_function	GO:0015278	calcium-release channel activity; IDA:UniProtKB.
# GO_function	GO:0032266	phosphatidylinositol-3-phosphate binding; IDA:UniProtKB.
# GO_function	GO:0070273	phosphatidylinositol-4-phosphate binding; IDA:UniProtKB.
# GO_function	GO:0070300	phosphatidic acid binding; IDA:UniProtKB.
# GO_function	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding; IDA:UniProtKB.
# GO_process	GO:0055024	regulation of cardiac muscle tissue development; IEA:Ensembl.
# GO_process	GO:0055074	calcium ion homeostasis; IDA:UniProtKB.
# GO_process	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity; TAS:BHF-UCL.
# GO_process	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity; IDA:UniProtKB.
# GO_process	GO:0060402	calcium ion transport into cytosol; TAS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0008289	lipid binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# Genevisible	Q9BR39	HS
# HGNC	HGNC:14202	JPH2
# InterPro	IPR003409	MORN
# InterPro	IPR017191	Junctophilin
# MIM	605267	gene
# MIM	613873	phenotype
# Organism	JPH2_HUMAN	Homo sapiens (Human)
# Orphanet	155	Familial isolated hypertrophic cardiomyopathy
# PIRSF	PIRSF037387	Junctophilin
# PTM	JPH2_HUMAN	Phosphorylation on Ser-165, probably by PKC, affects RYR1- mediated calcium ion release, interaction with TRPC3, and skeletal muscle myotubule development. {ECO 0000269|PubMed 20095964}. 
# Pfam	PF02493	MORN; 8
# Proteomes	UP000005640	Chromosome 20
# RecName	JPH2_HUMAN	Junctophilin-2
# RefSeq	NP_065166	NM_020433.4. [Q9BR39-1]
# RefSeq	NP_787109	NM_175913.3. [Q9BR39-2]
# SIMILARITY	Belongs to the junctophilin family. {ECO	0000305}. 
# SIMILARITY	Contains 8 MORN repeats. {ECO	0000305}.
# SMART	SM00698	MORN; 6
# SUBCELLULAR LOCATION	JPH2_HUMAN	Cell membrane {ECO 0000250}; Peripheral membrane protein {ECO 0000250}. Endoplasmic reticulum membrane {ECO 0000250}; Single-pass type IV membrane protein {ECO 0000250}. Sarcoplasmic reticulum membrane {ECO 0000250}; Single-pass type IV membrane protein {ECO 0000250}. Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In heart cells, it predominantly associates along Z lines within myocytes. In skeletal muscle, it is specifically localized at the junction of A and I bands (By similarity). {ECO 0000250}. 
# TISSUE SPECIFICITY	Specifically expressed in skeletal muscle and heart. {ECO:0000269|PubMed	10891348}. 
# UCSC	uc002xli	human. [Q9BR39-1]
# eggNOG	COG4642	LUCA
# eggNOG	KOG0231	Eukaryota
BLAST	swissprot:JPH2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:JPH2_HUMAN
BioCyc	ZFISH:ENSG00000149596-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000149596-MONOMER
COXPRESdb	57158	http://coxpresdb.jp/data/gene/57158.shtml
CleanEx	HS_JPH2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_JPH2
DOI	10.1006/bbrc.2000.3011	http://dx.doi.org/10.1006/bbrc.2000.3011
DOI	10.1007/s10038-007-0149-y	http://dx.doi.org/10.1007/s10038-007-0149-y
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.yjmcc.2007.04.006	http://dx.doi.org/10.1016/j.yjmcc.2007.04.006
DOI	10.1038/414865a	http://dx.doi.org/10.1038/414865a
DOI	10.1042/BJ20091225	http://dx.doi.org/10.1042/BJ20091225
DOI	10.1042/BJ20130591	http://dx.doi.org/10.1042/BJ20130591
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
EMBL	AL034419	http://www.ebi.ac.uk/ena/data/view/AL034419
EMBL	AL034419	http://www.ebi.ac.uk/ena/data/view/AL034419
EMBL	AL035447	http://www.ebi.ac.uk/ena/data/view/AL035447
EMBL	AL035447	http://www.ebi.ac.uk/ena/data/view/AL035447
EMBL	AL035447	http://www.ebi.ac.uk/ena/data/view/AL035447
EMBL	AL132999	http://www.ebi.ac.uk/ena/data/view/AL132999
EMBL	CH471077	http://www.ebi.ac.uk/ena/data/view/CH471077
EMBL	CH471077	http://www.ebi.ac.uk/ena/data/view/CH471077
Ensembl	ENST00000342272	http://www.ensembl.org/id/ENST00000342272
Ensembl	ENST00000372980	http://www.ensembl.org/id/ENST00000372980
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0014701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014701
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030018	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030018
GO_component	GO:0030314	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030314
GO_function	GO:0001786	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001786
GO_function	GO:0005546	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005546
GO_function	GO:0005547	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005547
GO_function	GO:0010314	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010314
GO_function	GO:0015278	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015278
GO_function	GO:0032266	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032266
GO_function	GO:0070273	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070273
GO_function	GO:0070300	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070300
GO_function	GO:0080025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0080025
GO_process	GO:0055024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055024
GO_process	GO:0055074	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055074
GO_process	GO:0060314	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060314
GO_process	GO:0060316	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060316
GO_process	GO:0060402	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060402
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GeneCards	JPH2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=JPH2
GeneID	57158	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57158
GeneTree	ENSGT00730000110639	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00730000110639
H-InvDB	HIX0015833	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0015833
HGNC	HGNC:14202	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14202
HOGENOM	HOG000264244	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264244&db=HOGENOM6
HOVERGEN	HBG031648	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG031648&db=HOVERGEN
HPA	HPA052646	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA052646
InParanoid	Q9BR39	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9BR39
InterPro	IPR003409	http://www.ebi.ac.uk/interpro/entry/IPR003409
InterPro	IPR017191	http://www.ebi.ac.uk/interpro/entry/IPR017191
Jabion	57158	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=57158
KEGG_Gene	hsa:57158	http://www.genome.jp/dbget-bin/www_bget?hsa:57158
MIM	605267	http://www.ncbi.nlm.nih.gov/omim/605267
MIM	613873	http://www.ncbi.nlm.nih.gov/omim/613873
OMA	HERETPR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HERETPR
Orphanet	155	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=155
OrthoDB	EOG091G03WX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G03WX
PSORT	swissprot:JPH2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:JPH2_HUMAN
PSORT-B	swissprot:JPH2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:JPH2_HUMAN
PSORT2	swissprot:JPH2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:JPH2_HUMAN
Pfam	PF02493	http://pfam.xfam.org/family/PF02493
PharmGKB	PA29999	http://www.pharmgkb.org/do/serve?objId=PA29999&objCls=Gene
Phobius	swissprot:JPH2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:JPH2_HUMAN
PhylomeDB	Q9BR39	http://phylomedb.org/?seqid=Q9BR39
ProteinModelPortal	Q9BR39	http://www.proteinmodelportal.org/query/uniprot/Q9BR39
PubMed	10891348	http://www.ncbi.nlm.nih.gov/pubmed/10891348
PubMed	11780052	http://www.ncbi.nlm.nih.gov/pubmed/11780052
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	17476457	http://www.ncbi.nlm.nih.gov/pubmed/17476457
PubMed	17509612	http://www.ncbi.nlm.nih.gov/pubmed/17509612
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	20095964	http://www.ncbi.nlm.nih.gov/pubmed/20095964
PubMed	24001019	http://www.ncbi.nlm.nih.gov/pubmed/24001019
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
RefSeq	NP_065166	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_065166
RefSeq	NP_787109	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_787109
SMART	SM00698	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00698
SMR	Q9BR39	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9BR39
STRING	9606.ENSP00000362071	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000362071&targetmode=cogs
UCSC	uc002xli	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002xli&org=rat
UniGene	Hs.441737	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.441737
UniProtKB	JPH2_HUMAN	http://www.uniprot.org/uniprot/JPH2_HUMAN
UniProtKB-AC	Q9BR39	http://www.uniprot.org/uniprot/Q9BR39
charge	swissprot:JPH2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:JPH2_HUMAN
eggNOG	COG4642	http://eggnogapi.embl.de/nog_data/html/tree/COG4642
eggNOG	KOG0231	http://eggnogapi.embl.de/nog_data/html/tree/KOG0231
epestfind	swissprot:JPH2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:JPH2_HUMAN
garnier	swissprot:JPH2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:JPH2_HUMAN
helixturnhelix	swissprot:JPH2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:JPH2_HUMAN
hmoment	swissprot:JPH2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:JPH2_HUMAN
iep	swissprot:JPH2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:JPH2_HUMAN
inforesidue	swissprot:JPH2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:JPH2_HUMAN
neXtProt	NX_Q9BR39	http://www.nextprot.org/db/entry/NX_Q9BR39
octanol	swissprot:JPH2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:JPH2_HUMAN
pepcoil	swissprot:JPH2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:JPH2_HUMAN
pepdigest	swissprot:JPH2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:JPH2_HUMAN
pepinfo	swissprot:JPH2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:JPH2_HUMAN
pepnet	swissprot:JPH2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:JPH2_HUMAN
pepstats	swissprot:JPH2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:JPH2_HUMAN
pepwheel	swissprot:JPH2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:JPH2_HUMAN
pepwindow	swissprot:JPH2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:JPH2_HUMAN
sigcleave	swissprot:JPH2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:JPH2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SVOPL_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N434-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q8N434-2; Sequence=VSP_026651, VSP_026652; Note=No experimental confirmation available.; 
# AltName	SVOPL_HUMAN	SV2-related protein-like
# AltName	SVOPL_HUMAN	SVOP-like protein
# CCDS	CCDS47721	-. [Q8N434-1]
# CCDS	CCDS5848	-. [Q8N434-2]
# CDD	cd06174	MFS
# Ensembl	ENST00000288513	ENSP00000288513; ENSG00000157703. [Q8N434-2]
# Ensembl	ENST00000419765	ENSP00000405482; ENSG00000157703. [Q8N434-1]
# Ensembl	ENST00000436657	ENSP00000417018; ENSG00000157703. [Q8N434-2]
# ExpressionAtlas	Q8N434	baseline and differential
# GO_component	GO:0016021	integral component of membrane; IBA:GO_Central.
# GO_function	GO:0022891	substrate-specific transmembrane transporter activity; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# Genevisible	Q8N434	HS
# HGNC	HGNC:27034	SVOPL
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# MIM	611700	gene
# Organism	SVOPL_HUMAN	Homo sapiens (Human)
# PROSITE	PS50850	MFS
# Pfam	PF00083	Sugar_tr
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 7
# RecName	SVOPL_HUMAN	Putative transporter SVOPL
# RefSeq	NP_001132928	NM_001139456.1. [Q8N434-1]
# RefSeq	NP_777619	NM_174959.3. [Q8N434-2]
# RefSeq	XP_005250200	XM_005250143.3. [Q8N434-1]
# RefSeq	XP_011514099	XM_011515797.2. [Q8N434-2]
# RefSeq	XP_016867236	XM_017011747.1. [Q8N434-2]
# RefSeq	XP_016867237	XM_017011748.1. [Q8N434-2]
# SIMILARITY	Belongs to the major facilitator superfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	SVOPL_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF103473	SSF103473
# UCSC	uc003vue	human. [Q8N434-1]
# eggNOG	ENOG410ZVDQ	LUCA
# eggNOG	KOG0253	Eukaryota
BLAST	swissprot:SVOPL_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SVOPL_HUMAN
BioCyc	ZFISH:ENSG00000157703-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000157703-MONOMER
COXPRESdb	136306	http://coxpresdb.jp/data/gene/136306.shtml
CleanEx	HS_SVOPL	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SVOPL
DOI	10.1016/j.ygeno.2007.03.017	http://dx.doi.org/10.1016/j.ygeno.2007.03.017
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC013429	http://www.ebi.ac.uk/ena/data/view/AC013429
EMBL	AC020983	http://www.ebi.ac.uk/ena/data/view/AC020983
EMBL	BC036796	http://www.ebi.ac.uk/ena/data/view/BC036796
Ensembl	ENST00000288513	http://www.ensembl.org/id/ENST00000288513
Ensembl	ENST00000419765	http://www.ensembl.org/id/ENST00000419765
Ensembl	ENST00000436657	http://www.ensembl.org/id/ENST00000436657
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0022891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022891
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GeneCards	SVOPL	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SVOPL
GeneID	136306	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=136306
GeneTree	ENSGT00550000074384	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074384
HGNC	HGNC:27034	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:27034
HOGENOM	HOG000114543	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000114543&db=HOGENOM6
HOVERGEN	HBG108527	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108527&db=HOVERGEN
HPA	HPA018035	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA018035
InParanoid	Q8N434	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8N434
IntAct	Q8N434	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8N434*
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	136306	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=136306
KEGG_Gene	hsa:136306	http://www.genome.jp/dbget-bin/www_bget?hsa:136306
MIM	611700	http://www.ncbi.nlm.nih.gov/omim/611700
OMA	ESHSPCH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ESHSPCH
OrthoDB	EOG091G04VD	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G04VD
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:SVOPL_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SVOPL_HUMAN
PSORT-B	swissprot:SVOPL_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SVOPL_HUMAN
PSORT2	swissprot:SVOPL_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SVOPL_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA162405089	http://www.pharmgkb.org/do/serve?objId=PA162405089&objCls=Gene
Phobius	swissprot:SVOPL_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SVOPL_HUMAN
PhylomeDB	Q8N434	http://phylomedb.org/?seqid=Q8N434
ProteinModelPortal	Q8N434	http://www.proteinmodelportal.org/query/uniprot/Q8N434
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17714910	http://www.ncbi.nlm.nih.gov/pubmed/17714910
RefSeq	NP_001132928	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001132928
RefSeq	NP_777619	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_777619
RefSeq	XP_005250200	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005250200
RefSeq	XP_011514099	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011514099
RefSeq	XP_016867236	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016867236
RefSeq	XP_016867237	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016867237
STRING	9606.ENSP00000405482	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000405482&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
UCSC	uc003vue	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003vue&org=rat
UniGene	Hs.99414	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.99414
UniProtKB	SVOPL_HUMAN	http://www.uniprot.org/uniprot/SVOPL_HUMAN
UniProtKB-AC	Q8N434	http://www.uniprot.org/uniprot/Q8N434
charge	swissprot:SVOPL_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SVOPL_HUMAN
eggNOG	ENOG410ZVDQ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZVDQ
eggNOG	KOG0253	http://eggnogapi.embl.de/nog_data/html/tree/KOG0253
epestfind	swissprot:SVOPL_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SVOPL_HUMAN
garnier	swissprot:SVOPL_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SVOPL_HUMAN
helixturnhelix	swissprot:SVOPL_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SVOPL_HUMAN
hmoment	swissprot:SVOPL_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SVOPL_HUMAN
iep	swissprot:SVOPL_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SVOPL_HUMAN
inforesidue	swissprot:SVOPL_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SVOPL_HUMAN
neXtProt	NX_Q8N434	http://www.nextprot.org/db/entry/NX_Q8N434
octanol	swissprot:SVOPL_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SVOPL_HUMAN
pepcoil	swissprot:SVOPL_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SVOPL_HUMAN
pepdigest	swissprot:SVOPL_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SVOPL_HUMAN
pepinfo	swissprot:SVOPL_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SVOPL_HUMAN
pepnet	swissprot:SVOPL_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SVOPL_HUMAN
pepstats	swissprot:SVOPL_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SVOPL_HUMAN
pepwheel	swissprot:SVOPL_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SVOPL_HUMAN
pepwindow	swissprot:SVOPL_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SVOPL_HUMAN
sigcleave	swissprot:SVOPL_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SVOPL_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	MOG1_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=MOG1a; IsoId=Q9HD47-1; Sequence=Displayed; Name=2; Synonyms=MOG1b; IsoId=Q9HD47-2; Sequence=VSP_033060; Name=3; IsoId=Q9HD47-3; Sequence=VSP_033059, VSP_033061; Name=4; IsoId=Q9HD47-4; Sequence=VSP_033057, VSP_033058; 
# AltName	MOG1_HUMAN	Ran-binding protein MOG1
# BioGrid	118866	19
# CCDS	CCDS11137	-. [Q9HD47-1]
# CCDS	CCDS54086	-. [Q9HD47-2]
# CCDS	CCDS54087	-. [Q9HD47-3]
# CCDS	CCDS82066	-. [Q9HD47-4]
# Ensembl	ENST00000226105	ENSP00000226105; ENSG00000108961. [Q9HD47-1]
# Ensembl	ENST00000407006	ENSP00000383940; ENSG00000108961. [Q9HD47-2]
# Ensembl	ENST00000439238	ENSP00000413190; ENSG00000108961. [Q9HD47-3]
# Ensembl	ENST00000580434	ENSP00000462310; ENSG00000108961. [Q9HD47-4]
# FUNCTION	MOG1_HUMAN	May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A. {ECO 0000269|PubMed 11290418, ECO 0000269|PubMed 18184654}. 
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005654	nucleoplasm; ISS:BHF-UCL.
# GO_component	GO:0005737	cytoplasm; IDA:BHF-UCL.
# GO_component	GO:0005791	rough endoplasmic reticulum; IDA:BHF-UCL.
# GO_component	GO:0005886	plasma membrane; IC:BHF-UCL.
# GO_component	GO:0005901	caveola; IDA:BHF-UCL.
# GO_component	GO:0014704	intercalated disc; ISS:BHF-UCL.
# GO_function	GO:0005085	guanyl-nucleotide exchange factor activity; ISS:BHF-UCL.
# GO_function	GO:0005087	Ran guanyl-nucleotide exchange factor activity; ISS:BHF-UCL.
# GO_function	GO:0008536	Ran GTPase binding; IPI:BHF-UCL.
# GO_function	GO:0008565	protein transporter activity; IMP:BHF-UCL.
# GO_function	GO:0017080	sodium channel regulator activity; IDA:BHF-UCL.
# GO_function	GO:0044325	ion channel binding; IPI:BHF-UCL.
# GO_process	GO:0002027	regulation of heart rate; TAS:BHF-UCL.
# GO_process	GO:0003254	regulation of membrane depolarization; IDA:BHF-UCL.
# GO_process	GO:0006888	ER to Golgi vesicle-mediated transport; IMP:BHF-UCL.
# GO_process	GO:0032527	protein exit from endoplasmic reticulum; IMP:BHF-UCL.
# GO_process	GO:0042391	regulation of membrane potential; IDA:BHF-UCL.
# GO_process	GO:0043547	positive regulation of GTPase activity; ISS:BHF-UCL.
# GO_process	GO:0090004	positive regulation of establishment of protein localization to plasma membrane; IMP:BHF-UCL.
# GO_process	GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential; TAS:BHF-UCL.
# GO_process	GO:1902305	regulation of sodium ion transmembrane transport; IDA:BHF-UCL.
# GO_process	GO:2000010	positive regulation of protein localization to cell surface; IDA:BHF-UCL.
# GO_process	GO:2000649	regulation of sodium ion transmembrane transporter activity; IDA:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# Gene3D	3.40.1000.10	-; 1.
# Genevisible	Q9HD47	HS
# HGNC	HGNC:17679	RANGRF
# IntAct	Q9HD47	2
# InterPro	IPR007681	Mog1
# InterPro	IPR016123	Mog1/PsbP_a/b/a-sand
# MIM	607954	gene
# Organism	MOG1_HUMAN	Homo sapiens (Human)
# Pfam	PF04603	Mog1
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# RecName	MOG1_HUMAN	Ran guanine nucleotide release factor
# RefSeq	NP_001171272	NM_001177801.1. [Q9HD47-2]
# RefSeq	NP_001171273	NM_001177802.1. [Q9HD47-3]
# RefSeq	NP_001317056	NM_001330127.1
# RefSeq	NP_057576	NM_016492.4. [Q9HD47-1]
# SEQUENCE CAUTION	Sequence=AAF29129.1; Type=Frameshift; Positions=62, 93; Evidence={ECO:0000305}; Sequence=AAF87316.1; Type=Frameshift; Positions=62; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the MOG1 family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	MOG1_HUMAN	Nucleus {ECO 0000269|PubMed 11290418}. Cytoplasm {ECO 0000250|UniProtKB Q9JIB0}. Note=May shuttle between the nucleus and cytoplasm. {ECO 0000269|PubMed 11290418}. 
# SUBUNIT	Monomer (By similarity). Interacts with RAN, RAN-GTP and RAN-GDP. Forms a complex with RAN-GTP and RANBP1 (By similarity). Interacts with the cytoplasmic loop 2 of SCN5A. {ECO:0000250, ECO	0000269|PubMed:18184654}. 
# SUPFAM	SSF55724	SSF55724
# TISSUE SPECIFICITY	Isoform 1 and isoform 2 are ubiquitously expressed. {ECO:0000269|PubMed	11290418}. 
# UCSC	uc002gkv	human. [Q9HD47-1]
# eggNOG	ENOG4111I9Z	LUCA
# eggNOG	KOG3329	Eukaryota
BLAST	swissprot:MOG1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MOG1_HUMAN
COXPRESdb	29098	http://coxpresdb.jp/data/gene/29098.shtml
CleanEx	HS_RANGRF	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_RANGRF
DOI	10.1016/S0378-1119(01)00364-X	http://dx.doi.org/10.1016/S0378-1119(01)00364-X
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M709721200	http://dx.doi.org/10.1074/jbc.M709721200
DOI	10.1101/gr.140200	http://dx.doi.org/10.1101/gr.140200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF151070	http://www.ebi.ac.uk/ena/data/view/AF151070
EMBL	AF161514	http://www.ebi.ac.uk/ena/data/view/AF161514
EMBL	AF168714	http://www.ebi.ac.uk/ena/data/view/AF168714
EMBL	AF265205	http://www.ebi.ac.uk/ena/data/view/AF265205
EMBL	AF265206	http://www.ebi.ac.uk/ena/data/view/AF265206
EMBL	AK290399	http://www.ebi.ac.uk/ena/data/view/AK290399
EMBL	BC006486	http://www.ebi.ac.uk/ena/data/view/BC006486
EMBL	BC012552	http://www.ebi.ac.uk/ena/data/view/BC012552
EMBL	BC100017	http://www.ebi.ac.uk/ena/data/view/BC100017
EMBL	CH471108	http://www.ebi.ac.uk/ena/data/view/CH471108
EMBL	CH471108	http://www.ebi.ac.uk/ena/data/view/CH471108
EMBL	CH471108	http://www.ebi.ac.uk/ena/data/view/CH471108
EMBL	CR457206	http://www.ebi.ac.uk/ena/data/view/CR457206
EMBL	CR749387	http://www.ebi.ac.uk/ena/data/view/CR749387
Ensembl	ENST00000226105	http://www.ensembl.org/id/ENST00000226105
Ensembl	ENST00000407006	http://www.ensembl.org/id/ENST00000407006
Ensembl	ENST00000439238	http://www.ensembl.org/id/ENST00000439238
Ensembl	ENST00000580434	http://www.ensembl.org/id/ENST00000580434
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005791	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005791
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005901
GO_component	GO:0014704	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014704
GO_function	GO:0005085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005085
GO_function	GO:0005087	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005087
GO_function	GO:0008536	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008536
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0017080	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017080
GO_function	GO:0044325	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044325
GO_process	GO:0002027	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002027
GO_process	GO:0003254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003254
GO_process	GO:0006888	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006888
GO_process	GO:0032527	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032527
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0043547	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043547
GO_process	GO:0090004	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090004
GO_process	GO:1900825	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900825
GO_process	GO:1902305	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902305
GO_process	GO:2000010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000010
GO_process	GO:2000649	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000649
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
Gene3D	3.40.1000.10	http://www.cathdb.info/version/latest/superfamily/3.40.1000.10
GeneCards	RANGRF	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=RANGRF
GeneID	29098	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29098
GeneTree	ENSGT00390000013834	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000013834
H-InvDB	HIX0013522	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0013522
HGNC	HGNC:17679	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17679
HOVERGEN	HBG075266	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG075266&db=HOVERGEN
HPA	HPA057280	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA057280
HPA	HPA057888	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA057888
InParanoid	Q9HD47	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9HD47
IntAct	Q9HD47	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9HD47*
InterPro	IPR007681	http://www.ebi.ac.uk/interpro/entry/IPR007681
InterPro	IPR016123	http://www.ebi.ac.uk/interpro/entry/IPR016123
Jabion	29098	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=29098
KEGG_Gene	hsa:29098	http://www.genome.jp/dbget-bin/www_bget?hsa:29098
MIM	607954	http://www.ncbi.nlm.nih.gov/omim/607954
OMA	QPLCLEN	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QPLCLEN
OrthoDB	EOG091G0KIN	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0KIN
PSORT	swissprot:MOG1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MOG1_HUMAN
PSORT-B	swissprot:MOG1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MOG1_HUMAN
PSORT2	swissprot:MOG1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MOG1_HUMAN
Pfam	PF04603	http://pfam.xfam.org/family/PF04603
PharmGKB	PA162400661	http://www.pharmgkb.org/do/serve?objId=PA162400661&objCls=Gene
Phobius	swissprot:MOG1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MOG1_HUMAN
PhylomeDB	Q9HD47	http://phylomedb.org/?seqid=Q9HD47
ProteinModelPortal	Q9HD47	http://www.proteinmodelportal.org/query/uniprot/Q9HD47
PubMed	11042152	http://www.ncbi.nlm.nih.gov/pubmed/11042152
PubMed	11290418	http://www.ncbi.nlm.nih.gov/pubmed/11290418
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18184654	http://www.ncbi.nlm.nih.gov/pubmed/18184654
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
RefSeq	NP_001171272	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001171272
RefSeq	NP_001171273	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001171273
RefSeq	NP_001317056	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001317056
RefSeq	NP_057576	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_057576
SMR	Q9HD47	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9HD47
STRING	9606.ENSP00000226105	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000226105&targetmode=cogs
SUPFAM	SSF55724	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55724
UCSC	uc002gkv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002gkv&org=rat
UniGene	Hs.408233	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.408233
UniProtKB	MOG1_HUMAN	http://www.uniprot.org/uniprot/MOG1_HUMAN
UniProtKB-AC	Q9HD47	http://www.uniprot.org/uniprot/Q9HD47
charge	swissprot:MOG1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MOG1_HUMAN
eggNOG	ENOG4111I9Z	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111I9Z
eggNOG	KOG3329	http://eggnogapi.embl.de/nog_data/html/tree/KOG3329
epestfind	swissprot:MOG1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MOG1_HUMAN
garnier	swissprot:MOG1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MOG1_HUMAN
helixturnhelix	swissprot:MOG1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MOG1_HUMAN
hmoment	swissprot:MOG1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MOG1_HUMAN
iep	swissprot:MOG1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MOG1_HUMAN
inforesidue	swissprot:MOG1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MOG1_HUMAN
neXtProt	NX_Q9HD47	http://www.nextprot.org/db/entry/NX_Q9HD47
octanol	swissprot:MOG1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MOG1_HUMAN
pepcoil	swissprot:MOG1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MOG1_HUMAN
pepdigest	swissprot:MOG1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MOG1_HUMAN
pepinfo	swissprot:MOG1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MOG1_HUMAN
pepnet	swissprot:MOG1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MOG1_HUMAN
pepstats	swissprot:MOG1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MOG1_HUMAN
pepwheel	swissprot:MOG1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MOG1_HUMAN
pepwindow	swissprot:MOG1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MOG1_HUMAN
sigcleave	swissprot:MOG1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MOG1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=3; Name=KvB1.3; IsoId=Q14722-1; Sequence=Displayed; Name=KvB1.1; IsoId=Q14722-2; Sequence=VSP_001051; Name=KvB1.2; IsoId=Q14722-3; Sequence=VSP_001050; Note=Ref.9 (AAC50113) sequence is in conflict in position: 16	L->S. {ECO:0000305}; 
# AltName	KCAB1_HUMAN	K(+) channel subunit beta-1
# AltName	KCAB1_HUMAN	Kv-beta-1
# BioGrid	113626	12
# CCDS	CCDS3174	-. [Q14722-1]
# CCDS	CCDS3175	-. [Q14722-3]
# CCDS	CCDS33882	-. [Q14722-2]
# CDD	cd06660	Aldo_ket_red
# ChiTaRS	KCNAB1	human
# DOMAIN	KCAB1_HUMAN	The N-terminal domain of the beta subunit mediates closure of delayed rectifier potassium channels by physically obstructing the pore. {ECO 0000269|PubMed 19713757, ECO 0000269|PubMed 9763623}. 
# Ensembl	ENST00000302490	ENSP00000305858; ENSG00000169282. [Q14722-2]
# Ensembl	ENST00000471742	ENSP00000418956; ENSG00000169282. [Q14722-3]
# Ensembl	ENST00000490337	ENSP00000419952; ENSG00000169282. [Q14722-1]
# ExpressionAtlas	Q14722	baseline and differential
# FUNCTION	KCAB1_HUMAN	Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed 7499366, PubMed 7603988, PubMed 17156368,PubMed 17540341, PubMed 19713757). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed 9763623). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (PubMed 7499366, PubMed 7890032, PubMed 7603988, PubMed 7649300, PubMed 8938711, PubMed 12077175, PubMed 12130714, PubMed 15361858, PubMed 17540341, PubMed 19713757). Accelerates KCNA4 channel closure (PubMed 7890032, PubMed 7649300, PubMed 7890764, PubMed 9763623). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (PubMed 17156368). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity). Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1 (PubMed 7890032, PubMed 7890764). Enhances KCNB1 and KCNB2 channel activity (By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity (PubMed 17540341). Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity). {ECO 0000250|UniProtKB P63143, ECO 0000250|UniProtKB P63144, ECO 0000269|PubMed 12077175, ECO 0000269|PubMed 12130714, ECO 0000269|PubMed 15361858, ECO 0000269|PubMed 17156368, ECO 0000269|PubMed 17540341, ECO 0000269|PubMed 19713757, ECO 0000269|PubMed 7499366, ECO 0000269|PubMed 7603988, ECO 0000269|PubMed 7649300, ECO 0000269|PubMed 7890032, ECO 0000269|PubMed 7890764, ECO 0000269|PubMed 8938711, ECO 0000269|PubMed 9763623, ECO 0000305}. 
# GO_component	GO:0005829	cytosol; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IEA:Ensembl.
# GO_component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0032839	dendrite cytoplasm; IEA:Ensembl.
# GO_component	GO:0034705	potassium channel complex; IDA:UniProtKB.
# GO_component	GO:0043204	perikaryon; IEA:Ensembl.
# GO_component	GO:0044224	juxtaparanode region of axon; IEA:Ensembl.
# GO_component	GO:1990635	proximal dendrite; IEA:Ensembl.
# GO_function	GO:0004033	aldo-keto reductase (NADP) activity; ISS:UniProtKB.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IEA:InterPro.
# GO_function	GO:0015459	potassium channel regulator activity; IDA:UniProtKB.
# GO_function	GO:0070402	NADPH binding; IDA:UniProtKB.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0007420	brain development; IEA:Ensembl.
# GO_process	GO:0007507	heart development; IEA:Ensembl.
# GO_process	GO:0007519	skeletal muscle tissue development; IEA:Ensembl.
# GO_process	GO:0007611	learning or memory; IEA:Ensembl.
# GO_process	GO:0045445	myoblast differentiation; IEA:Ensembl.
# GO_process	GO:0055114	oxidation-reduction process; ISS:UniProtKB.
# GO_process	GO:0060539	diaphragm development; IEA:Ensembl.
# GO_process	GO:1901379	regulation of potassium ion transmembrane transport; IDA:UniProtKB.
# GO_process	GO:1902259	regulation of delayed rectifier potassium channel activity; ISS:UniProtKB.
# GO_process	GO:1902260	negative regulation of delayed rectifier potassium channel activity; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# Gene3D	3.20.20.100	-; 1.
# Genevisible	Q14722	HS
# HGNC	HGNC:6228	KCNAB1
# IntAct	Q14722	2
# InterPro	IPR001395	Aldo/ket_red/Kv-b
# InterPro	IPR005399	K_chnl_volt-dep_bsu_KCNAB-rel
# InterPro	IPR005400	K_chnl_volt-dep_bsu_KCNAB1
# InterPro	IPR005983	K_chnl_volt-dep_bsu_KCNAB
# InterPro	IPR023210	NADP_OxRdtase_dom
# KEGG_Brite	ko04040	Ion channels
# MIM	601141	gene
# Organism	KCAB1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11732	PTHR11732
# PIR	I55463	I55463
# PIR	I59393	I59393
# PRINTS	PR01577	KCNABCHANNEL
# PRINTS	PR01578	KCNAB1CHANEL
# Pfam	PF00248	Aldo_ket_red
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# RecName	KCAB1_HUMAN	Voltage-gated potassium channel subunit beta-1
# RefSeq	NP_001295146	NM_001308217.1
# RefSeq	NP_001295151	NM_001308222.1
# RefSeq	NP_003462	NM_003471.3. [Q14722-3]
# RefSeq	NP_751891	NM_172159.3. [Q14722-2]
# RefSeq	NP_751892	NM_172160.2. [Q14722-1]
# SIMILARITY	Belongs to the shaker potassium channel beta subunit family. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCAB1_HUMAN	Cytoplasm {ECO 0000269|PubMed 17540341}. Membrane {ECO 0000250|UniProtKB P63144}; Peripheral membrane protein {ECO 0000305}; Cytoplasmic side {ECO 0000305}. Cell membrane {ECO 0000269|PubMed 17540341}; Peripheral membrane protein {ECO 0000269|PubMed 17540341}; Cytoplasmic side {ECO 0000269|PubMed 17540341}. Note=Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits. {ECO 0000269|PubMed 17540341}. 
# SUBUNIT	KCAB1_HUMAN	Homotetramer (By similarity). Interaction with tetrameric potassium channel alpha subunits gives rise to a heterooctamer (Probable). Identified in potassium channel complexes containing KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNAB1 and KCNAB2 (By similarity). Interacts with KCNA1 (By similarity). Interacts with the dimer formed by GNB1 and GNG2; this enhances KCNA1 binding (By similarity). Interacts with KCNA4 (PubMed 9763623). Interacts with KCNA5 (PubMed 12130714). Interacts with KCNB2 (By similarity). Interacts with SQSTM1 (By similarity). Part of a complex containing KCNA1, KCNA4 and LGI1; interaction with LGI1 inhibits down-regulation of KCNA1 channel activity (By similarity). {ECO 0000250|UniProtKB P63143, ECO 0000250|UniProtKB P63144, ECO 0000269|PubMed 12130714, ECO 0000269|PubMed 9763623, ECO 0000305}. 
# SUPFAM	SSF51430	SSF51430
# TCDB	8.A.5.1	the voltage-gated k(+) channel -subunit (kv) family
# TIGRFAMs	TIGR01293	Kv_beta
# TISSUE SPECIFICITY	KCAB1_HUMAN	In brain, expression is most prominent in caudate nucleus, hippocampus and thalamus. Significant expression also detected in amygdala and subthalamic nucleus. Also expressed in both healthy and cardiomyopathic heart. Up to four times more abundant in left ventricle than left atrium. {ECO 0000269|PubMed 7603988, ECO 0000269|PubMed 8938711}. 
# UCSC	uc003far	human. [Q14722-1]
# eggNOG	COG0667	LUCA
# eggNOG	KOG1575	Eukaryota
BLAST	swissprot:KCAB1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCAB1_HUMAN
BioCyc	ZFISH:ENSG00000169282-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000169282-MONOMER
COXPRESdb	7881	http://coxpresdb.jp/data/gene/7881.shtml
CleanEx	HS_KCNAB1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNAB1
DOI	10.1016/0014-5793(95)00120-X	http://dx.doi.org/10.1016/0014-5793(95)00120-X
DOI	10.1016/0014-5793(95)00785-8	http://dx.doi.org/10.1016/0014-5793(95)00785-8
DOI	10.1016/0028-3908(96)00133-5	http://dx.doi.org/10.1016/0028-3908(96)00133-5
DOI	10.1016/j.bbrc.2007.05.102	http://dx.doi.org/10.1016/j.bbrc.2007.05.102
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/nsmb825	http://dx.doi.org/10.1038/nsmb825
DOI	10.1073/pnas.92.14.6309	http://dx.doi.org/10.1073/pnas.92.14.6309
DOI	10.1074/jbc.270.11.6272	http://dx.doi.org/10.1074/jbc.270.11.6272
DOI	10.1074/jbc.270.48.28531	http://dx.doi.org/10.1074/jbc.270.48.28531
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1460-9568.2006.05186.x	http://dx.doi.org/10.1111/j.1460-9568.2006.05186.x
DOI	10.1111/j.1469-7793.1998.325be.x	http://dx.doi.org/10.1111/j.1469-7793.1998.325be.x
DOI	10.1124/jpet.102.033357	http://dx.doi.org/10.1124/jpet.102.033357
DOI	10.4161/chan.3.5.9558	http://dx.doi.org/10.4161/chan.3.5.9558
DisProt	DP00090	http://www.disprot.org/protein.php?id=DP00090
EC_number	EC:1.1.1.- {ECO:0000250|UniProtKB:P63144}	http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.- {ECO:0000250|UniProtKB:P63144}
EMBL	AK057059	http://www.ebi.ac.uk/ena/data/view/AK057059
EMBL	AK127240	http://www.ebi.ac.uk/ena/data/view/AK127240
EMBL	AK292693	http://www.ebi.ac.uk/ena/data/view/AK292693
EMBL	AK292999	http://www.ebi.ac.uk/ena/data/view/AK292999
EMBL	BC043166	http://www.ebi.ac.uk/ena/data/view/BC043166
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
EMBL	L39833	http://www.ebi.ac.uk/ena/data/view/L39833
EMBL	L47665	http://www.ebi.ac.uk/ena/data/view/L47665
EMBL	U16953	http://www.ebi.ac.uk/ena/data/view/U16953
EMBL	U17968	http://www.ebi.ac.uk/ena/data/view/U17968
EMBL	U33428	http://www.ebi.ac.uk/ena/data/view/U33428
EMBL	X83127	http://www.ebi.ac.uk/ena/data/view/X83127
ENZYME	1.1.1.- {ECO:0000250|UniProtKB:P63144}	http://enzyme.expasy.org/EC/1.1.1.- {ECO:0000250|UniProtKB:P63144}
Ensembl	ENST00000302490	http://www.ensembl.org/id/ENST00000302490
Ensembl	ENST00000471742	http://www.ensembl.org/id/ENST00000471742
Ensembl	ENST00000490337	http://www.ensembl.org/id/ENST00000490337
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0031234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031234
GO_component	GO:0032839	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032839
GO_component	GO:0034705	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034705
GO_component	GO:0043204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043204
GO_component	GO:0044224	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044224
GO_component	GO:1990635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990635
GO_function	GO:0004033	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004033
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0015459	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015459
GO_function	GO:0070402	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070402
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0007420	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007420
GO_process	GO:0007507	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007507
GO_process	GO:0007519	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007519
GO_process	GO:0007611	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007611
GO_process	GO:0045445	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045445
GO_process	GO:0055114	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114
GO_process	GO:0060539	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060539
GO_process	GO:1901379	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901379
GO_process	GO:1902259	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902259
GO_process	GO:1902260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902260
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
Gene3D	3.20.20.100	http://www.cathdb.info/version/latest/superfamily/3.20.20.100
GeneCards	KCNAB1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNAB1
GeneID	7881	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7881
GeneTree	ENSGT00550000074567	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074567
HGNC	HGNC:6228	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6228
HOVERGEN	HBG052216	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052216&db=HOVERGEN
HPA	HPA044550	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA044550
InParanoid	Q14722	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q14722
IntAct	Q14722	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q14722*
IntEnz	1.1.1.- {ECO:0000250|UniProtKB:P63144}	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.- {ECO:0000250|UniProtKB:P63144}
InterPro	IPR001395	http://www.ebi.ac.uk/interpro/entry/IPR001395
InterPro	IPR005399	http://www.ebi.ac.uk/interpro/entry/IPR005399
InterPro	IPR005400	http://www.ebi.ac.uk/interpro/entry/IPR005400
InterPro	IPR005983	http://www.ebi.ac.uk/interpro/entry/IPR005983
InterPro	IPR023210	http://www.ebi.ac.uk/interpro/entry/IPR023210
Jabion	7881	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7881
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:7881	http://www.genome.jp/dbget-bin/www_bget?hsa:7881
KEGG_Orthology	KO:K04882	http://www.genome.jp/dbget-bin/www_bget?KO:K04882
MIM	601141	http://www.ncbi.nlm.nih.gov/omim/601141
OMA	MGLVVWS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MGLVVWS
OrthoDB	EOG091G0KDN	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0KDN
PANTHER	PTHR11732	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11732
PRINTS	PR01577	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01577
PRINTS	PR01578	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01578
PSORT	swissprot:KCAB1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCAB1_HUMAN
PSORT-B	swissprot:KCAB1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCAB1_HUMAN
PSORT2	swissprot:KCAB1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCAB1_HUMAN
Pfam	PF00248	http://pfam.xfam.org/family/PF00248
PharmGKB	PA370	http://www.pharmgkb.org/do/serve?objId=PA370&objCls=Gene
Phobius	swissprot:KCAB1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCAB1_HUMAN
PhylomeDB	Q14722	http://phylomedb.org/?seqid=Q14722
ProteinModelPortal	Q14722	http://www.proteinmodelportal.org/query/uniprot/Q14722
PubMed	12077175	http://www.ncbi.nlm.nih.gov/pubmed/12077175
PubMed	12130714	http://www.ncbi.nlm.nih.gov/pubmed/12130714
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15361858	http://www.ncbi.nlm.nih.gov/pubmed/15361858
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17156368	http://www.ncbi.nlm.nih.gov/pubmed/17156368
PubMed	17540341	http://www.ncbi.nlm.nih.gov/pubmed/17540341
PubMed	19713757	http://www.ncbi.nlm.nih.gov/pubmed/19713757
PubMed	7499366	http://www.ncbi.nlm.nih.gov/pubmed/7499366
PubMed	7603988	http://www.ncbi.nlm.nih.gov/pubmed/7603988
PubMed	7649300	http://www.ncbi.nlm.nih.gov/pubmed/7649300
PubMed	7890032	http://www.ncbi.nlm.nih.gov/pubmed/7890032
PubMed	7890764	http://www.ncbi.nlm.nih.gov/pubmed/7890764
PubMed	8938711	http://www.ncbi.nlm.nih.gov/pubmed/8938711
PubMed	9763623	http://www.ncbi.nlm.nih.gov/pubmed/9763623
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
RefSeq	NP_001295146	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001295146
RefSeq	NP_001295151	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001295151
RefSeq	NP_003462	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003462
RefSeq	NP_751891	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_751891
RefSeq	NP_751892	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_751892
SMR	Q14722	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q14722
STRING	9606.ENSP00000419952	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000419952&targetmode=cogs
SUPFAM	SSF51430	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51430
TCDB	8.A.5.1	http://www.tcdb.org/search/result.php?tc=8.A.5.1
TIGRFAMs	TIGR01293	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01293
UCSC	uc003far	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003far&org=rat
UniGene	Hs.654519	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.654519
UniGene	Hs.703187	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.703187
UniProtKB	KCAB1_HUMAN	http://www.uniprot.org/uniprot/KCAB1_HUMAN
UniProtKB-AC	Q14722	http://www.uniprot.org/uniprot/Q14722
charge	swissprot:KCAB1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCAB1_HUMAN
eggNOG	COG0667	http://eggnogapi.embl.de/nog_data/html/tree/COG0667
eggNOG	KOG1575	http://eggnogapi.embl.de/nog_data/html/tree/KOG1575
epestfind	swissprot:KCAB1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCAB1_HUMAN
garnier	swissprot:KCAB1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCAB1_HUMAN
helixturnhelix	swissprot:KCAB1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCAB1_HUMAN
hmoment	swissprot:KCAB1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCAB1_HUMAN
iep	swissprot:KCAB1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCAB1_HUMAN
inforesidue	swissprot:KCAB1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCAB1_HUMAN
neXtProt	NX_Q14722	http://www.nextprot.org/db/entry/NX_Q14722
octanol	swissprot:KCAB1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCAB1_HUMAN
pepcoil	swissprot:KCAB1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCAB1_HUMAN
pepdigest	swissprot:KCAB1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCAB1_HUMAN
pepinfo	swissprot:KCAB1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCAB1_HUMAN
pepnet	swissprot:KCAB1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCAB1_HUMAN
pepstats	swissprot:KCAB1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCAB1_HUMAN
pepwheel	swissprot:KCAB1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCAB1_HUMAN
pepwindow	swissprot:KCAB1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCAB1_HUMAN
sigcleave	swissprot:KCAB1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCAB1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	DLG1_HUMAN	Event=Alternative splicing; Named isoforms=9; Name=1; IsoId=Q12959-1; Sequence=Displayed; Name=2; IsoId=Q12959-2; Sequence=VSP_003150; Note=Contains a phosphoserine at position 709. {ECO 0000244|PubMed 24275569}; Name=3; IsoId=Q12959-3; Sequence=VSP_012862; Name=4; IsoId=Q12959-4; Sequence=VSP_012862, VSP_003150; Note=Ref.6 (AAI44652) sequence is in conflict in position  636 Q->Missing. Contains a phosphoserine at position 676. {ECO 0000244|PubMed 24275569, ECO 0000305}; Name=5; IsoId=Q12959-5; Sequence=VSP_012862, VSP_012863; Name=6; IsoId=Q12959-6; Sequence=VSP_012864; Name=7; IsoId=Q12959-7; Sequence=VSP_012865; Name=8; IsoId=Q12959-8; Sequence=VSP_045896, VSP_045897; Note=No experimental confirmation available.; Name=9; IsoId=Q12959-9; Sequence=VSP_045896, VSP_045897, VSP_012865, VSP_045898; Note=No experimental confirmation available.; 
# AltName	DLG1_HUMAN	Synapse-associated protein 97
# AltName	DLG1_HUMAN	hDlg
# BioGrid	108083	57
# CCDS	CCDS3327	-. [Q12959-2]
# CCDS	CCDS43194	-. [Q12959-1]
# CCDS	CCDS56300	-. [Q12959-8]
# CCDS	CCDS56301	-. [Q12959-9]
# ChiTaRS	DLG1	human
# DOMAIN	DLG1_HUMAN	The L27 domain may regulate DLG1 self-association. The N- terminal alternatively spliced region is capable of binding several SH3 domains and also moderates the level of protein oligomerization. 
# DOMAIN	DLG1_HUMAN	The PDZ domains may also mediate association to membranes by binding to EPB41 and ADGRA2 together with the L27 domain that binds CASK and DLG2. 
# DOMAIN	DLG1_HUMAN	The alternatively spliced domain I3 corresponding to amino acids (636-669) of isoform 4 is an EPB41 binding site mediating association to membranes in polarized and non-polarized cells. 
# Ensembl	ENST00000346964	ENSP00000345731; ENSG00000075711. [Q12959-2]
# Ensembl	ENST00000392382	ENSP00000376187; ENSG00000075711. [Q12959-3]
# Ensembl	ENST00000419354	ENSP00000407531; ENSG00000075711. [Q12959-1]
# Ensembl	ENST00000422288	ENSP00000413238; ENSG00000075711. [Q12959-5]
# Ensembl	ENST00000443183	ENSP00000396658; ENSG00000075711. [Q12959-9]
# Ensembl	ENST00000448528	ENSP00000391732; ENSG00000075711. [Q12959-1]
# Ensembl	ENST00000450955	ENSP00000411278; ENSG00000075711. [Q12959-4]
# Ensembl	ENST00000452595	ENSP00000398939; ENSG00000075711. [Q12959-8]
# ExpressionAtlas	Q12959	baseline and differential
# FUNCTION	DLG1_HUMAN	Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. {ECO 0000250, ECO 0000269|PubMed 10656683, ECO 0000269|PubMed 12445884, ECO 0000269|PubMed 14699157, ECO 0000269|PubMed 15263016, ECO 0000269|PubMed 19213956, ECO 0000269|PubMed 20605917}. 
# GO_component	GO:0001772	immunological synapse; IDA:UniProtKB.
# GO_component	GO:0005605	basal lamina; IEA:Ensembl.
# GO_component	GO:0005634	nucleus; IDA:BHF-UCL.
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005783	endoplasmic reticulum; IDA:UniProtKB.
# GO_component	GO:0005789	endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005794	Golgi apparatus; IDA:UniProtKB.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0005874	microtubule; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005911	cell-cell junction; IDA:UniProtKB.
# GO_component	GO:0005913	cell-cell adherens junction; IDA:BHF-UCL.
# GO_component	GO:0005923	bicellular tight junction; IDA:BHF-UCL.
# GO_component	GO:0009898	cytoplasmic side of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0014069	postsynaptic density; IBA:GO_Central.
# GO_component	GO:0014704	intercalated disc; TAS:BHF-UCL.
# GO_component	GO:0016323	basolateral plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016328	lateral plasma membrane; IEA:Ensembl.
# GO_component	GO:0030054	cell junction; IDA:UniProtKB.
# GO_component	GO:0031253	cell projection membrane; IEA:Ensembl.
# GO_component	GO:0031594	neuromuscular junction; IEA:Ensembl.
# GO_component	GO:0033268	node of Ranvier; IEA:Ensembl.
# GO_component	GO:0035748	myelin sheath abaxonal region; IEA:Ensembl.
# GO_component	GO:0042383	sarcolemma; IEA:UniProtKB-SubCell.
# GO_component	GO:0043219	lateral loop; IEA:Ensembl.
# GO_component	GO:0045121	membrane raft; IEA:Ensembl.
# GO_component	GO:0045211	postsynaptic membrane; IBA:GO_Central.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_component	GO:0097025	MPP7-DLG1-LIN7 complex; IDA:BHF-UCL.
# GO_function	GO:0004385	guanylate kinase activity; TAS:ProtInc.
# GO_function	GO:0004721	phosphoprotein phosphatase activity; TAS:UniProtKB.
# GO_function	GO:0008022	protein C-terminus binding; IPI:UniProtKB.
# GO_function	GO:0008092	cytoskeletal protein binding; TAS:ProtInc.
# GO_function	GO:0015276	ligand-gated ion channel activity; TAS:Reactome.
# GO_function	GO:0015459	potassium channel regulator activity; NAS:UniProtKB.
# GO_function	GO:0019901	protein kinase binding; IPI:UniProtKB.
# GO_function	GO:0019902	phosphatase binding; IPI:UniProtKB.
# GO_function	GO:0031434	mitogen-activated protein kinase kinase binding; IPI:UniProtKB.
# GO_function	GO:0035255	ionotropic glutamate receptor binding; IBA:GO_Central.
# GO_function	GO:0044325	ion channel binding; IPI:BHF-UCL.
# GO_function	GO:0097016	L27 domain binding; IPI:BHF-UCL.
# GO_function	GO:0098641	cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
# GO_process	GO:0000122	negative regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.
# GO_process	GO:0001658	branching involved in ureteric bud morphogenesis; IEA:Ensembl.
# GO_process	GO:0001771	immunological synapse formation; IEA:Ensembl.
# GO_process	GO:0001935	endothelial cell proliferation; IDA:UniProtKB.
# GO_process	GO:0002088	lens development in camera-type eye; IEA:Ensembl.
# GO_process	GO:0002369	T cell cytokine production; IEA:Ensembl.
# GO_process	GO:0007015	actin filament organization; IDA:UniProtKB.
# GO_process	GO:0007093	mitotic cell cycle checkpoint; NAS:UniProtKB.
# GO_process	GO:0007163	establishment or maintenance of cell polarity; TAS:UniProtKB.
# GO_process	GO:0007268	chemical synaptic transmission; IBA:GO_Central.
# GO_process	GO:0007399	nervous system development; IBA:GO_Central.
# GO_process	GO:0008284	positive regulation of cell proliferation; IEA:Ensembl.
# GO_process	GO:0008360	regulation of cell shape; IMP:UniProtKB.
# GO_process	GO:0016032	viral process; IEA:UniProtKB-KW.
# GO_process	GO:0016337	single organismal cell-cell adhesion; IDA:UniProtKB.
# GO_process	GO:0030432	peristalsis; IEA:Ensembl.
# GO_process	GO:0030838	positive regulation of actin filament polymerization; IEA:Ensembl.
# GO_process	GO:0030866	cortical actin cytoskeleton organization; IDA:UniProtKB.
# GO_process	GO:0030953	astral microtubule organization; IMP:UniProtKB.
# GO_process	GO:0031579	membrane raft organization; IEA:Ensembl.
# GO_process	GO:0031641	regulation of myelination; IEA:Ensembl.
# GO_process	GO:0032147	activation of protein kinase activity; IEA:Ensembl.
# GO_process	GO:0034629	cellular protein complex localization; IMP:UniProtKB.
# GO_process	GO:0042110	T cell activation; IEA:Ensembl.
# GO_process	GO:0042130	negative regulation of T cell proliferation; IEA:Ensembl.
# GO_process	GO:0042391	regulation of membrane potential; IDA:BHF-UCL.
# GO_process	GO:0042982	amyloid precursor protein metabolic process; IEA:Ensembl.
# GO_process	GO:0043113	receptor clustering; IBA:GO_Central.
# GO_process	GO:0043268	positive regulation of potassium ion transport; IDA:BHF-UCL.
# GO_process	GO:0043622	cortical microtubule organization; IMP:UniProtKB.
# GO_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity; IBA:GO_Central.
# GO_process	GO:0045930	negative regulation of mitotic cell cycle; IMP:UniProtKB.
# GO_process	GO:0048608	reproductive structure development; IEA:Ensembl.
# GO_process	GO:0048704	embryonic skeletal system morphogenesis; IEA:Ensembl.
# GO_process	GO:0048745	smooth muscle tissue development; IEA:Ensembl.
# GO_process	GO:0050680	negative regulation of epithelial cell proliferation; IEA:Ensembl.
# GO_process	GO:0051660	establishment of centrosome localization; IMP:UniProtKB.
# GO_process	GO:0051898	negative regulation of protein kinase B signaling; IEA:Ensembl.
# GO_process	GO:0060022	hard palate development; IEA:Ensembl.
# GO_process	GO:0070373	negative regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.
# GO_process	GO:0070830	bicellular tight junction assembly; IDA:BHF-UCL.
# GO_process	GO:0072659	protein localization to plasma membrane; IMP:BHF-UCL.
# GO_process	GO:0090004	positive regulation of establishment of protein localization to plasma membrane; IDA:BHF-UCL.
# GO_process	GO:0097120	receptor localization to synapse; IBA:GO_Central.
# GO_process	GO:1902305	regulation of sodium ion transmembrane transport; TAS:BHF-UCL.
# GO_process	GO:1903753	negative regulation of p38MAPK cascade; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008092	cytoskeletal protein binding
# GOslim_function	GO:0016301	kinase activity
# GOslim_function	GO:0016791	phosphatase activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0007009	plasma membrane organization
# GOslim_process	GO:0007010	cytoskeleton organization
# GOslim_process	GO:0007155	cell adhesion
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0008283	cell proliferation
# GOslim_process	GO:0022607	cellular component assembly
# GOslim_process	GO:0034330	cell junction organization
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0061024	membrane organization
# Gene3D	2.30.42.10	-; 3.
# Gene3D	3.40.50.300	-; 2.
# Genevisible	Q12959	HS
# HGNC	HGNC:2900	DLG1
# INTERACTION	DLG1_HUMAN	P78536 ADAM17; NbExp=7; IntAct=EBI-357481, EBI-78188; Q96PE1 ADGRA2; NbExp=2; IntAct=EBI-357500, EBI-10893263; Q8IWK6-3 ADGRA3; NbExp=2; IntAct=EBI-357500, EBI-10949249; Q9Y297 BTRC; NbExp=2; IntAct=EBI-357481, EBI-307461; P31016 Dlg4 (xeno); NbExp=9; IntAct=EBI-357500, EBI-375655; O57125 E6 (xeno); NbExp=2; IntAct=EBI-357481, EBI-7461590; P03126 E6 (xeno); NbExp=2; IntAct=EBI-357481, EBI-1177242; P06463 E6 (xeno); NbExp=3; IntAct=EBI-357481, EBI-1186926; P36799 E6 (xeno); NbExp=2; IntAct=EBI-357481, EBI-7363822; Q9NQT8 KIF13B; NbExp=3; IntAct=EBI-357500, EBI-766408; O60333-3 KIF1B; NbExp=4; IntAct=EBI-357481, EBI-465669; P36507 MAP2K2; NbExp=10; IntAct=EBI-357481, EBI-1056930; Q9ICL1 se6 (xeno); NbExp=3; IntAct=EBI-357481, EBI-7461477; 
# IntAct	Q12959	41
# InterPro	IPR001452	SH3_domain
# InterPro	IPR001478	PDZ
# InterPro	IPR004172	L27_dom
# InterPro	IPR008144	Guanylate_kin-like_dom
# InterPro	IPR008145	GK/Ca_channel_bsu
# InterPro	IPR011511	SH3_2
# InterPro	IPR015143	L27_1
# InterPro	IPR016313	DLG1
# InterPro	IPR019583	PDZ_assoc
# InterPro	IPR019590	DLG1_PEST_dom
# InterPro	IPR020590	Guanylate_kinase_CS
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko03036	 Chromosome
# KEGG_Pathway	ko04390	Hippo signaling pathway
# KEGG_Pathway	ko04391	Hippo signaling pathway - fly
# KEGG_Pathway	ko04660	T cell receptor signaling pathway
# KEGG_Pathway	ko05166	HTLV-I infection
# KEGG_Pathway	ko05203	Viral carcinogenesis
# MIM	601014	gene
# Organism	DLG1_HUMAN	Homo sapiens (Human)
# PDB	1PDR	X-ray; 2.80 A; A=457-555
# PDB	2M3M	NMR; -; A=318-406
# PDB	2OQS	NMR; -; A=318-406
# PDB	2X7Z	X-ray; 2.00 A; A=311-407
# PDB	3LRA	X-ray; 2.95 A; A=2-65
# PDB	3RL7	X-ray; 2.30 A; A/B/C/D/E/F=220-317
# PDB	3RL8	X-ray; 2.20 A; A/B/C/D/E=315-410
# PDB	3W9Y	X-ray; 2.20 A; A=712-904
# PDB	4AMH	X-ray; 2.30 A; A/B=315-405
# PDB	4G69	X-ray; 2.00 A; A=310-407
# PIR	I38756	I38756
# PIR	I38757	I38757
# PIRSF	PIRSF001741	MAGUK_DLGH
# PROSITE	PS00856	GUANYLATE_KINASE_1
# PROSITE	PS50002	SH3
# PROSITE	PS50052	GUANYLATE_KINASE_2
# PROSITE	PS50106	PDZ; 3
# PROSITE	PS51022	L27
# PTM	DLG1_HUMAN	Phosphorylated by MAPK12. Phosphorylation of Ser-232 regulates association with GRIN2A (By similarity). {ECO 0000250}. 
# Pfam	PF00595	PDZ; 3
# Pfam	PF00625	Guanylate_kin
# Pfam	PF07653	SH3_2
# Pfam	PF09058	L27_1
# Pfam	PF10600	PDZ_assoc
# Pfam	PF10608	MAGUK_N_PEST
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-399719	Trafficking of AMPA receptors
# Reactome	R-HSA-447038	NrCAM interactions
# Reactome	R-HSA-451308	Activation of Ca-permeable Kainate Receptor
# Reactome	R-HSA-8849932	SALM protein interactions at the synapses
# RecName	DLG1_HUMAN	Disks large homolog 1
# RefSeq	NP_001091894	NM_001098424.1. [Q12959-1]
# RefSeq	NP_001191315	NM_001204386.1
# RefSeq	NP_001191316	NM_001204387.1. [Q12959-9]
# RefSeq	NP_001191317	NM_001204388.1. [Q12959-8]
# RefSeq	NP_001277912	NM_001290983.1. [Q12959-1]
# RefSeq	NP_004078	NM_004087.2. [Q12959-2]
# RefSeq	XP_005269346	XM_005269289.3. [Q12959-2]
# RefSeq	XP_011510804	XM_011512502.2. [Q12959-1]
# RefSeq	XP_011510805	XM_011512503.1
# RefSeq	XP_011510807	XM_011512505.1. [Q12959-3]
# RefSeq	XP_011510808	XM_011512506.1. [Q12959-5]
# RefSeq	XP_016861289	XM_017005800.1. [Q12959-2]
# RefSeq	XP_016861290	XM_017005801.1. [Q12959-2]
# RefSeq	XP_016861291	XM_017005802.1. [Q12959-2]
# RefSeq	XP_016861292	XM_017005803.1. [Q12959-2]
# RefSeq	XP_016861294	XM_017005805.1. [Q12959-1]
# RefSeq	XP_016861295	XM_017005806.1. [Q12959-4]
# RefSeq	XP_016861296	XM_017005807.1. [Q12959-4]
# RefSeq	XP_016861297	XM_017005808.1. [Q12959-4]
# RefSeq	XP_016861298	XM_017005809.1. [Q12959-4]
# RefSeq	XP_016861299	XM_017005810.1
# RefSeq	XP_016861305	XM_017005816.1. [Q12959-3]
# RefSeq	XP_016861306	XM_017005817.1. [Q12959-3]
# RefSeq	XP_016861307	XM_017005818.1. [Q12959-3]
# RefSeq	XP_016861308	XM_017005819.1. [Q12959-3]
# RefSeq	XP_016861309	XM_017005820.1. [Q12959-5]
# SIMILARITY	Belongs to the MAGUK family. {ECO	0000305}. 
# SIMILARITY	Contains 1 L27 domain. {ECO:0000255|PROSITE- ProRule	PRU00365}. 
# SIMILARITY	Contains 1 SH3 domain. {ECO:0000255|PROSITE- ProRule	PRU00192}. 
# SIMILARITY	Contains 1 guanylate kinase-like domain. {ECO:0000255|PROSITE-ProRule	PRU00100}. 
# SIMILARITY	Contains 3 PDZ (DHR) domains. {ECO:0000255|PROSITE- ProRule	PRU00143}. 
# SMART	SM00072	GuKc
# SMART	SM00228	PDZ; 3
# SMART	SM00326	SH3
# SMART	SM00569	L27
# SMART	SM01277	MAGUK_N_PEST
# SUBCELLULAR LOCATION	DLG1_HUMAN	Membrane {ECO 0000250}; Peripheral membrane protein {ECO 0000250}. Basolateral cell membrane {ECO 0000250}. Endoplasmic reticulum membrane {ECO 0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO 0000250}. Cell junction, synapse. Cell membrane, sarcolemma. Note=Colocalizes with EPB41 at regions of intercellular contacts. Basolateral in epithelial cells. May also associate with endoplasmic reticulum membranes. Mainly found in neurons soma, moderately found at postsynaptic densities (By similarity). {ECO 0000250}. 
# SUBUNIT	DLG1_HUMAN	Homotetramer (Probable). Interacts (via guanylate kinase- like domain) with DLGAP1, DLGAP2, DLGAP3, DLGAP4 and MAP1A (By similarity). Interacts (via guanylate kinase-like domain) with KIF13B (PubMed 10859302). May interact with HTR2A (By similarity). Interacts (via PDZ domains) with GRIA1 (By similarity). Interacts (via PDZ domains) with GRIN2A (By similarity). Interacts (via PDZ domains) with KCND2 and KCND3 (PubMed 19213956). Interacts (via PDZ domains) with KCNA1, KCNA2, KCNA3 and KCNA4 (PubMed 7477295). Interacts (via PDZ domains) with ADGRA3 (PubMed 15021905). Interacts with KCNF1 (PubMed 12445884). Interacts with CAMK2 (By similarity). Interacts with cytoskeleton-associated protein EPB41 (PubMed 7937897, PubMed 8922391). Interacts with cytoskeleton- associated protein EZR (By similarity). Found in a complex with KCNA5 and CAV3 (By similarity). Found in a complex with APC and CTNNB1 (PubMed 8638125, PubMed 10656683). Interacts with CDH1 through binding to PIK3R1 (PubMed 14699157). Forms multiprotein complexes with CASK, LIN7A, LIN7B, LIN7C, APBA1, and KCNJ12 (By similarity). Interacts with TOPK (PubMed 10779557). Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C) (PubMed 17237226, PubMed 17332497, PubMed 20702775). May interact with TJAP1 (PubMed 11602598). Interacts with PTEN (By similarity). Interacts with FRMPD4 (via C-terminus) (PubMed 19118189). Interacts with LRFN1, LRFN2 and LRFN4 (PubMed 16630835). Interacts with SFPQ (PubMed 20605917). Interacts (via PDZ domains) with ADGRA2 (via PDZ-binding motif) (PubMed 15021905, PubMed 25558062). Interacts with the HTLV-1 viral Tax and HPV-18 E6 papillomavirus (HPV) oncoproteins (PubMed 9192623, PubMed 10557085). {ECO 0000250|UniProtKB Q62696, ECO 0000250|UniProtKB Q811D0, ECO 0000269|PubMed 10557085, ECO 0000269|PubMed 10656683, ECO 0000269|PubMed 10779557, ECO 0000269|PubMed 10859302, ECO 0000269|PubMed 12445884, ECO 0000269|PubMed 14699157, ECO 0000269|PubMed 15021905, ECO 0000269|PubMed 16630835, ECO 0000269|PubMed 17237226, ECO 0000269|PubMed 17332497, ECO 0000269|PubMed 19118189, ECO 0000269|PubMed 19213956, ECO 0000269|PubMed 20605917, ECO 0000269|PubMed 20702775, ECO 0000269|PubMed 25558062, ECO 0000269|PubMed 7477295, ECO 0000269|PubMed 7937897, ECO 0000269|PubMed 8638125, ECO 0000269|PubMed 8922391, ECO 0000269|PubMed 9192623, ECO 0000305}. 
# SUPFAM	SSF101288	SSF101288
# SUPFAM	SSF50044	SSF50044; 2
# SUPFAM	SSF50156	SSF50156; 3
# SUPFAM	SSF52540	SSF52540
# TISSUE SPECIFICITY	DLG1_HUMAN	Abundantly expressed in atrial myocardium (at protein level). Expressed in lung fibroblasts, cervical epithelial and B-cells (at protein level). Widely expressed, with isoforms displaying different expression profiles. {ECO 0000269|PubMed 12445884, ECO 0000269|PubMed 19213956, ECO 0000269|PubMed 7937897}. 
# UCSC	uc003fxn	human. [Q12959-1]
# WEB RESOURCE	DLG1_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/DLG1ID40333ch3q29.html";
# eggNOG	COG0194	LUCA
# eggNOG	KOG0708	Eukaryota
BLAST	swissprot:DLG1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:DLG1_HUMAN
BioCyc	ZFISH:ENSG00000075711-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000075711-MONOMER
COXPRESdb	1739	http://coxpresdb.jp/data/gene/1739.shtml
CleanEx	HS_DLG1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_DLG1
DIP	DIP-33957N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-33957N
DOI	10.1002/bies.10286	http://dx.doi.org/10.1002/bies.10286
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/S0008-6363(02)00602-8	http://dx.doi.org/10.1016/S0008-6363(02)00602-8
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.celrep.2014.12.020	http://dx.doi.org/10.1016/j.celrep.2014.12.020
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.neuron.2006.04.005	http://dx.doi.org/10.1016/j.neuron.2006.04.005
DOI	10.1021/pr0705441	http://dx.doi.org/10.1021/pr0705441
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/378085a0	http://dx.doi.org/10.1038/378085a0
DOI	10.1038/382649a0	http://dx.doi.org/10.1038/382649a0
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.onc.1203008	http://dx.doi.org/10.1038/sj.onc.1203008
DOI	10.1038/sj.onc.1203309	http://dx.doi.org/10.1038/sj.onc.1203309
DOI	10.1038/sj.onc.1207495	http://dx.doi.org/10.1038/sj.onc.1207495
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.090102397	http://dx.doi.org/10.1073/pnas.090102397
DOI	10.1073/pnas.91.21.9818	http://dx.doi.org/10.1073/pnas.91.21.9818
DOI	10.1073/pnas.94.13.6670	http://dx.doi.org/10.1073/pnas.94.13.6670
DOI	10.1074/jbc.M000715200	http://dx.doi.org/10.1074/jbc.M000715200
DOI	10.1074/jbc.M107335200	http://dx.doi.org/10.1074/jbc.M107335200
DOI	10.1074/jbc.M108724200	http://dx.doi.org/10.1074/jbc.M108724200
DOI	10.1074/jbc.M305209200	http://dx.doi.org/10.1074/jbc.M305209200
DOI	10.1074/jbc.M309843200	http://dx.doi.org/10.1074/jbc.M309843200
DOI	10.1074/jbc.M610002200	http://dx.doi.org/10.1074/jbc.M610002200
DOI	10.1083/jcb.135.4.1125	http://dx.doi.org/10.1083/jcb.135.4.1125
DOI	10.1083/jcb.200309044	http://dx.doi.org/10.1083/jcb.200309044
DOI	10.1091/mbc.E06-11-0980	http://dx.doi.org/10.1091/mbc.E06-11-0980
DOI	10.1096/fj.10-163857	http://dx.doi.org/10.1096/fj.10-163857
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.272.5264.1020	http://dx.doi.org/10.1126/science.272.5264.1020
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1161/CIRCRESAHA.108.191007	http://dx.doi.org/10.1161/CIRCRESAHA.108.191007
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1242/jcs.066514	http://dx.doi.org/10.1242/jcs.066514
DOI	10.1523/JNEUROSCI.3112-08.2008	http://dx.doi.org/10.1523/JNEUROSCI.3112-08.2008
EMBL	AC068302	http://www.ebi.ac.uk/ena/data/view/AC068302
EMBL	AC092937	http://www.ebi.ac.uk/ena/data/view/AC092937
EMBL	AK294772	http://www.ebi.ac.uk/ena/data/view/AK294772
EMBL	AK294855	http://www.ebi.ac.uk/ena/data/view/AK294855
EMBL	BC140841	http://www.ebi.ac.uk/ena/data/view/BC140841
EMBL	BC144651	http://www.ebi.ac.uk/ena/data/view/BC144651
EMBL	CH471191	http://www.ebi.ac.uk/ena/data/view/CH471191
EMBL	CH471191	http://www.ebi.ac.uk/ena/data/view/CH471191
EMBL	CH471191	http://www.ebi.ac.uk/ena/data/view/CH471191
EMBL	CH471191	http://www.ebi.ac.uk/ena/data/view/CH471191
EMBL	EF553524	http://www.ebi.ac.uk/ena/data/view/EF553524
EMBL	U13896	http://www.ebi.ac.uk/ena/data/view/U13896
EMBL	U13897	http://www.ebi.ac.uk/ena/data/view/U13897
Ensembl	ENST00000346964	http://www.ensembl.org/id/ENST00000346964
Ensembl	ENST00000392382	http://www.ensembl.org/id/ENST00000392382
Ensembl	ENST00000419354	http://www.ensembl.org/id/ENST00000419354
Ensembl	ENST00000422288	http://www.ensembl.org/id/ENST00000422288
Ensembl	ENST00000443183	http://www.ensembl.org/id/ENST00000443183
Ensembl	ENST00000448528	http://www.ensembl.org/id/ENST00000448528
Ensembl	ENST00000450955	http://www.ensembl.org/id/ENST00000450955
Ensembl	ENST00000452595	http://www.ensembl.org/id/ENST00000452595
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0001772	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001772
GO_component	GO:0005605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005605
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005874
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005911	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005911
GO_component	GO:0005913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005913
GO_component	GO:0005923	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005923
GO_component	GO:0009898	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009898
GO_component	GO:0014069	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014069
GO_component	GO:0014704	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014704
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0016328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016328
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0031253	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031253
GO_component	GO:0031594	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031594
GO_component	GO:0033268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033268
GO_component	GO:0035748	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035748
GO_component	GO:0042383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042383
GO_component	GO:0043219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043219
GO_component	GO:0045121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045121
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_component	GO:0097025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097025
GO_function	GO:0004385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004385
GO_function	GO:0004721	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004721
GO_function	GO:0008022	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008022
GO_function	GO:0008092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_function	GO:0015459	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015459
GO_function	GO:0019901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019901
GO_function	GO:0019902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019902
GO_function	GO:0031434	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031434
GO_function	GO:0035255	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035255
GO_function	GO:0044325	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044325
GO_function	GO:0097016	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097016
GO_function	GO:0098641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098641
GO_process	GO:0000122	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000122
GO_process	GO:0001658	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001658
GO_process	GO:0001771	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001771
GO_process	GO:0001935	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001935
GO_process	GO:0002088	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002088
GO_process	GO:0002369	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002369
GO_process	GO:0007015	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007015
GO_process	GO:0007093	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007093
GO_process	GO:0007163	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007163
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007399	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007399
GO_process	GO:0008284	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008284
GO_process	GO:0008360	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360
GO_process	GO:0016032	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016032
GO_process	GO:0016337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016337
GO_process	GO:0030432	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030432
GO_process	GO:0030838	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030838
GO_process	GO:0030866	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030866
GO_process	GO:0030953	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030953
GO_process	GO:0031579	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031579
GO_process	GO:0031641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031641
GO_process	GO:0032147	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032147
GO_process	GO:0034629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034629
GO_process	GO:0042110	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042110
GO_process	GO:0042130	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042130
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0042982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042982
GO_process	GO:0043113	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043113
GO_process	GO:0043268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043268
GO_process	GO:0043622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043622
GO_process	GO:0045197	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045197
GO_process	GO:0045930	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045930
GO_process	GO:0048608	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048608
GO_process	GO:0048704	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048704
GO_process	GO:0048745	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048745
GO_process	GO:0050680	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050680
GO_process	GO:0051660	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051660
GO_process	GO:0051898	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051898
GO_process	GO:0060022	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060022
GO_process	GO:0070373	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070373
GO_process	GO:0070830	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070830
GO_process	GO:0072659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072659
GO_process	GO:0090004	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090004
GO_process	GO:0097120	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097120
GO_process	GO:1902305	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902305
GO_process	GO:1903753	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903753
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GOslim_function	GO:0016301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301
GOslim_function	GO:0016791	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0007009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007009
GOslim_process	GO:0007010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007010
GOslim_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0008283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008283
GOslim_process	GO:0022607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607
GOslim_process	GO:0034330	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034330
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
Gene3D	2.30.42.10	http://www.cathdb.info/version/latest/superfamily/2.30.42.10
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	DLG1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=DLG1
GeneID	1739	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1739
GeneTree	ENSGT00760000118866	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118866
HGNC	HGNC:2900	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2900
HOGENOM	HOG000232102	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000232102&db=HOGENOM6
HOVERGEN	HBG107814	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG107814&db=HOVERGEN
HPA	CAB016307	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB016307
HPA	HPA069593	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA069593
InParanoid	Q12959	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q12959
IntAct	Q12959	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q12959*
InterPro	IPR001452	http://www.ebi.ac.uk/interpro/entry/IPR001452
InterPro	IPR001478	http://www.ebi.ac.uk/interpro/entry/IPR001478
InterPro	IPR004172	http://www.ebi.ac.uk/interpro/entry/IPR004172
InterPro	IPR008144	http://www.ebi.ac.uk/interpro/entry/IPR008144
InterPro	IPR008145	http://www.ebi.ac.uk/interpro/entry/IPR008145
InterPro	IPR011511	http://www.ebi.ac.uk/interpro/entry/IPR011511
InterPro	IPR015143	http://www.ebi.ac.uk/interpro/entry/IPR015143
InterPro	IPR016313	http://www.ebi.ac.uk/interpro/entry/IPR016313
InterPro	IPR019583	http://www.ebi.ac.uk/interpro/entry/IPR019583
InterPro	IPR019590	http://www.ebi.ac.uk/interpro/entry/IPR019590
InterPro	IPR020590	http://www.ebi.ac.uk/interpro/entry/IPR020590
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	1739	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1739
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko03036	http://www.genome.jp/dbget-bin/www_bget?ko03036
KEGG_Gene	hsa:1739	http://www.genome.jp/dbget-bin/www_bget?hsa:1739
KEGG_Orthology	KO:K12076	http://www.genome.jp/dbget-bin/www_bget?KO:K12076
KEGG_Pathway	ko04390	http://www.genome.jp/kegg-bin/show_pathway?ko04390
KEGG_Pathway	ko04391	http://www.genome.jp/kegg-bin/show_pathway?ko04391
KEGG_Pathway	ko04660	http://www.genome.jp/kegg-bin/show_pathway?ko04660
KEGG_Pathway	ko05166	http://www.genome.jp/kegg-bin/show_pathway?ko05166
KEGG_Pathway	ko05203	http://www.genome.jp/kegg-bin/show_pathway?ko05203
MIM	601014	http://www.ncbi.nlm.nih.gov/omim/601014
MINT	MINT-107690	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-107690
OMA	THEHAVT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=THEHAVT
OrthoDB	EOG091G0BB1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0BB1
PDB	1PDR	http://www.ebi.ac.uk/pdbe-srv/view/entry/1PDR
PDB	2M3M	http://www.ebi.ac.uk/pdbe-srv/view/entry/2M3M
PDB	2OQS	http://www.ebi.ac.uk/pdbe-srv/view/entry/2OQS
PDB	2X7Z	http://www.ebi.ac.uk/pdbe-srv/view/entry/2X7Z
PDB	3LRA	http://www.ebi.ac.uk/pdbe-srv/view/entry/3LRA
PDB	3RL7	http://www.ebi.ac.uk/pdbe-srv/view/entry/3RL7
PDB	3RL8	http://www.ebi.ac.uk/pdbe-srv/view/entry/3RL8
PDB	3W9Y	http://www.ebi.ac.uk/pdbe-srv/view/entry/3W9Y
PDB	4AMH	http://www.ebi.ac.uk/pdbe-srv/view/entry/4AMH
PDB	4G69	http://www.ebi.ac.uk/pdbe-srv/view/entry/4G69
PDBsum	1PDR	http://www.ebi.ac.uk/pdbsum/1PDR
PDBsum	2M3M	http://www.ebi.ac.uk/pdbsum/2M3M
PDBsum	2OQS	http://www.ebi.ac.uk/pdbsum/2OQS
PDBsum	2X7Z	http://www.ebi.ac.uk/pdbsum/2X7Z
PDBsum	3LRA	http://www.ebi.ac.uk/pdbsum/3LRA
PDBsum	3RL7	http://www.ebi.ac.uk/pdbsum/3RL7
PDBsum	3RL8	http://www.ebi.ac.uk/pdbsum/3RL8
PDBsum	3W9Y	http://www.ebi.ac.uk/pdbsum/3W9Y
PDBsum	4AMH	http://www.ebi.ac.uk/pdbsum/4AMH
PDBsum	4G69	http://www.ebi.ac.uk/pdbsum/4G69
PROSITE	PS00856	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00856
PROSITE	PS50002	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50002
PROSITE	PS50052	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50052
PROSITE	PS50106	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50106
PROSITE	PS51022	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51022
PSORT	swissprot:DLG1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:DLG1_HUMAN
PSORT-B	swissprot:DLG1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:DLG1_HUMAN
PSORT2	swissprot:DLG1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:DLG1_HUMAN
Pfam	PF00595	http://pfam.xfam.org/family/PF00595
Pfam	PF00625	http://pfam.xfam.org/family/PF00625
Pfam	PF07653	http://pfam.xfam.org/family/PF07653
Pfam	PF09058	http://pfam.xfam.org/family/PF09058
Pfam	PF10600	http://pfam.xfam.org/family/PF10600
Pfam	PF10608	http://pfam.xfam.org/family/PF10608
PharmGKB	PA27356	http://www.pharmgkb.org/do/serve?objId=PA27356&objCls=Gene
Phobius	swissprot:DLG1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:DLG1_HUMAN
PhylomeDB	Q12959	http://phylomedb.org/?seqid=Q12959
ProteinModelPortal	Q12959	http://www.proteinmodelportal.org/query/uniprot/Q12959
PubMed	10557085	http://www.ncbi.nlm.nih.gov/pubmed/10557085
PubMed	10656683	http://www.ncbi.nlm.nih.gov/pubmed/10656683
PubMed	10779557	http://www.ncbi.nlm.nih.gov/pubmed/10779557
PubMed	10859302	http://www.ncbi.nlm.nih.gov/pubmed/10859302
PubMed	11602598	http://www.ncbi.nlm.nih.gov/pubmed/11602598
PubMed	11723125	http://www.ncbi.nlm.nih.gov/pubmed/11723125
PubMed	12445884	http://www.ncbi.nlm.nih.gov/pubmed/12445884
PubMed	12766944	http://www.ncbi.nlm.nih.gov/pubmed/12766944
PubMed	12807908	http://www.ncbi.nlm.nih.gov/pubmed/12807908
PubMed	14699157	http://www.ncbi.nlm.nih.gov/pubmed/14699157
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15021905	http://www.ncbi.nlm.nih.gov/pubmed/15021905
PubMed	15263016	http://www.ncbi.nlm.nih.gov/pubmed/15263016
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16630835	http://www.ncbi.nlm.nih.gov/pubmed/16630835
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	17237226	http://www.ncbi.nlm.nih.gov/pubmed/17237226
PubMed	17332497	http://www.ncbi.nlm.nih.gov/pubmed/17332497
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18220336	http://www.ncbi.nlm.nih.gov/pubmed/18220336
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19118189	http://www.ncbi.nlm.nih.gov/pubmed/19118189
PubMed	19213956	http://www.ncbi.nlm.nih.gov/pubmed/19213956
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	20605917	http://www.ncbi.nlm.nih.gov/pubmed/20605917
PubMed	20702775	http://www.ncbi.nlm.nih.gov/pubmed/20702775
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25558062	http://www.ncbi.nlm.nih.gov/pubmed/25558062
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	7477295	http://www.ncbi.nlm.nih.gov/pubmed/7477295
PubMed	7937897	http://www.ncbi.nlm.nih.gov/pubmed/7937897
PubMed	8638125	http://www.ncbi.nlm.nih.gov/pubmed/8638125
PubMed	8757139	http://www.ncbi.nlm.nih.gov/pubmed/8757139
PubMed	8922391	http://www.ncbi.nlm.nih.gov/pubmed/8922391
PubMed	9192623	http://www.ncbi.nlm.nih.gov/pubmed/9192623
Reactome	R-HSA-399719	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-399719
Reactome	R-HSA-447038	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-447038
Reactome	R-HSA-451308	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-451308
Reactome	R-HSA-8849932	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8849932
RefSeq	NP_001091894	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001091894
RefSeq	NP_001191315	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001191315
RefSeq	NP_001191316	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001191316
RefSeq	NP_001191317	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001191317
RefSeq	NP_001277912	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001277912
RefSeq	NP_004078	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004078
RefSeq	XP_005269346	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005269346
RefSeq	XP_011510804	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011510804
RefSeq	XP_011510805	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011510805
RefSeq	XP_011510807	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011510807
RefSeq	XP_011510808	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011510808
RefSeq	XP_016861289	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016861289
RefSeq	XP_016861290	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016861290
RefSeq	XP_016861291	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016861291
RefSeq	XP_016861292	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016861292
RefSeq	XP_016861294	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016861294
RefSeq	XP_016861295	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016861295
RefSeq	XP_016861296	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016861296
RefSeq	XP_016861297	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016861297
RefSeq	XP_016861298	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016861298
RefSeq	XP_016861299	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016861299
RefSeq	XP_016861305	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016861305
RefSeq	XP_016861306	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016861306
RefSeq	XP_016861307	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016861307
RefSeq	XP_016861308	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016861308
RefSeq	XP_016861309	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016861309
SMART	SM00072	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00072
SMART	SM00228	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00228
SMART	SM00326	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00326
SMART	SM00569	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00569
SMART	SM01277	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01277
SMR	Q12959	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q12959
STRING	9606.ENSP00000345731	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000345731&targetmode=cogs
SUPFAM	SSF101288	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF101288
SUPFAM	SSF50044	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50044
SUPFAM	SSF50156	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50156
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
UCSC	uc003fxn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003fxn&org=rat
UniGene	Hs.292549	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.292549
UniProtKB	DLG1_HUMAN	http://www.uniprot.org/uniprot/DLG1_HUMAN
UniProtKB-AC	Q12959	http://www.uniprot.org/uniprot/Q12959
charge	swissprot:DLG1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:DLG1_HUMAN
eggNOG	COG0194	http://eggnogapi.embl.de/nog_data/html/tree/COG0194
eggNOG	KOG0708	http://eggnogapi.embl.de/nog_data/html/tree/KOG0708
epestfind	swissprot:DLG1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:DLG1_HUMAN
garnier	swissprot:DLG1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:DLG1_HUMAN
helixturnhelix	swissprot:DLG1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:DLG1_HUMAN
hmoment	swissprot:DLG1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:DLG1_HUMAN
iep	swissprot:DLG1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:DLG1_HUMAN
inforesidue	swissprot:DLG1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:DLG1_HUMAN
neXtProt	NX_Q12959	http://www.nextprot.org/db/entry/NX_Q12959
octanol	swissprot:DLG1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:DLG1_HUMAN
pepcoil	swissprot:DLG1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:DLG1_HUMAN
pepdigest	swissprot:DLG1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:DLG1_HUMAN
pepinfo	swissprot:DLG1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:DLG1_HUMAN
pepnet	swissprot:DLG1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:DLG1_HUMAN
pepstats	swissprot:DLG1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:DLG1_HUMAN
pepwheel	swissprot:DLG1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:DLG1_HUMAN
pepwindow	swissprot:DLG1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:DLG1_HUMAN
sigcleave	swissprot:DLG1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:DLG1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	PIEZ2_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9H5I5-1; Sequence=Displayed; Name=2; IsoId=Q9H5I5-2; Sequence=VSP_040472; Note=No experimental confirmation available.; Name=3; IsoId=Q9H5I5-3; Sequence=VSP_040471; Note=No experimental confirmation available.; Name=4; IsoId=Q9H5I5-4; Sequence=VSP_040630; Note=No experimental confirmation available.; 
# AltName	PIEZ2_HUMAN	Protein FAM38B
# CCDS	CCDS11850	-. [Q9H5I5-1]
# ChiTaRS	PIEZO2	human
# DISEASE	PIEZ2_HUMAN	Arthrogryposis, distal, 3 (DA3) [MIM 114300]  A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. DA3 features include short stature and cleft palate. {ECO 0000269|PubMed 24726473}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	PIEZ2_HUMAN	Arthrogryposis, distal, 5 (DA5) [MIM 108145]  A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. DA5 features include ocular abnormalities, typically ptosis, ophthalmoplegia and/or strabismus, in addition to contractures of the skeletal muscles. Some patients have pulmonary hypertension as a result of restrictive lung disease. {ECO 0000269|PubMed 23487782}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	PIEZ2_HUMAN	Marden-Walker syndrome (MWKS) [MIM 248700]  A syndrome characterized by a mask-like face with blepharophimosis, micrognathia, cleft or high-arched palate, low-set ears, congenital joint contractures, kyphoscoliosis, pectus excavatum or carinatum, and arachnodactyly. Additional features include decreased muscular mass, failure to thrive, renal anomalies, hypoplastic corpus callosum, cerebellar vermis hypoplasia, enlarged cisterna magna, and psychomotor retardation. {ECO 0000269|PubMed 24726473}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000302079	ENSP00000303316; ENSG00000154864. [Q9H5I5-2]
# Ensembl	ENST00000503781	ENSP00000421377; ENSG00000154864. [Q9H5I5-1]
# Ensembl	ENST00000538948	ENSP00000443129; ENSG00000154864. [Q9H5I5-3]
# Ensembl	ENST00000580640	ENSP00000463094; ENSG00000154864. [Q9H5I5-4]
# ExpressionAtlas	Q9H5I5	baseline and differential
# FUNCTION	PIEZ2_HUMAN	Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light- touch mechanosensation. {ECO 0000250|UniProtKB Q8CD54}. 
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0008381	mechanically-gated ion channel activity; IEA:InterPro.
# GO_process	GO:0006812	cation transport; ISS:UniProtKB.
# GO_process	GO:0009612	response to mechanical stimulus; ISS:UniProtKB.
# GO_process	GO:0050974	detection of mechanical stimulus involved in sensory perception; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q9H5I5	HS
# HGNC	HGNC:26270	PIEZO2
# InterPro	IPR027272	Piezo
# InterPro	IPR031334	Piezo_RRas-bd_dom
# InterPro	IPR031805	Piezo_dom
# MIM	108145	phenotype
# MIM	114300	phenotype
# MIM	248700	phenotype
# MIM	613629	gene
# MISCELLANEOUS	PIEZ2_HUMAN	Piezo comes from the Greek 'piesi' meaning pressure. 
# Organism	PIEZ2_HUMAN	Homo sapiens (Human)
# Orphanet	1154	Arthrogryposis with oculomotor limitation and electroretinal anomalies
# Orphanet	2461	Marden-Walker syndrome
# Orphanet	376	Gordon syndrome
# PANTHER	PTHR13167	PTHR13167; 3
# Pfam	PF12166	Piezo_RRas_bdg
# Pfam	PF15917	PIEZO
# Proteomes	UP000005640	Chromosome 18
# RecName	PIEZ2_HUMAN	Piezo-type mechanosensitive ion channel component 2
# RefSeq	NP_071351	NM_022068.3. [Q9H5I5-1]
# RefSeq	XP_011524026	XM_011525724.2. [Q9H5I5-4]
# SEQUENCE CAUTION	PIEZ2_HUMAN	Sequence=BAB15556.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=BAB15556.1; Type=Erroneous termination; Positions=2718; Note=Translated as Arg.; Evidence={ECO 0000305}; Sequence=BAB15641.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=BAC03832.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO 0000305}; Sequence=BAC05412.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=BAC05412.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence at the 3'end. Probable cloning artifact.; Evidence={ECO 0000305};
# SIMILARITY	Belongs to the PIEZO (TC 1.A.75) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	PIEZ2_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUBUNIT	Homooligomer, most likely homotetramer. Interacts with STOML3. {ECO:0000250|UniProtKB	Q8CD54}. 
# TCDB	1.A.75.1	the mechanical nociceptor, piezo (piezo) family
# UCSC	uc002koq	human. [Q9H5I5-1]
# eggNOG	ENOG410YVF6	LUCA
# eggNOG	KOG1893	Eukaryota
BLAST	swissprot:PIEZ2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:PIEZ2_HUMAN
BioCyc	ZFISH:ENSG00000154864-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000154864-MONOMER
COXPRESdb	63895	http://coxpresdb.jp/data/gene/63895.shtml
CleanEx	HS_FAM38B	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_FAM38B
DOI	10.1016/j.ajhg.2014.03.015	http://dx.doi.org/10.1016/j.ajhg.2014.03.015
DOI	10.1038/nature03983	http://dx.doi.org/10.1038/nature03983
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.1221400110	http://dx.doi.org/10.1073/pnas.1221400110
EMBL	AK026797	http://www.ebi.ac.uk/ena/data/view/AK026797
EMBL	AK027056	http://www.ebi.ac.uk/ena/data/view/AK027056
EMBL	AK092226	http://www.ebi.ac.uk/ena/data/view/AK092226
EMBL	AK098782	http://www.ebi.ac.uk/ena/data/view/AK098782
EMBL	AK127627	http://www.ebi.ac.uk/ena/data/view/AK127627
EMBL	AK302764	http://www.ebi.ac.uk/ena/data/view/AK302764
EMBL	AP001180	http://www.ebi.ac.uk/ena/data/view/AP001180
EMBL	AP005117	http://www.ebi.ac.uk/ena/data/view/AP005117
EMBL	AP005120	http://www.ebi.ac.uk/ena/data/view/AP005120
EMBL	AP005404	http://www.ebi.ac.uk/ena/data/view/AP005404
EMBL	AP005793	http://www.ebi.ac.uk/ena/data/view/AP005793
EMBL	JN790819	http://www.ebi.ac.uk/ena/data/view/JN790819
Ensembl	ENST00000302079	http://www.ensembl.org/id/ENST00000302079
Ensembl	ENST00000503781	http://www.ensembl.org/id/ENST00000503781
Ensembl	ENST00000538948	http://www.ensembl.org/id/ENST00000538948
Ensembl	ENST00000580640	http://www.ensembl.org/id/ENST00000580640
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0008381	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008381
GO_process	GO:0006812	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006812
GO_process	GO:0009612	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009612
GO_process	GO:0050974	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050974
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	PIEZO2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=PIEZO2
GeneID	63895	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=63895
GeneTree	ENSGT00390000013029	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000013029
HGNC	HGNC:26270	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:26270
HOVERGEN	HBG060934	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG060934&db=HOVERGEN
HPA	HPA015986	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA015986
HPA	HPA031974	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031974
HPA	HPA040616	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA040616
InParanoid	Q9H5I5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9H5I5
InterPro	IPR027272	http://www.ebi.ac.uk/interpro/entry/IPR027272
InterPro	IPR031334	http://www.ebi.ac.uk/interpro/entry/IPR031334
InterPro	IPR031805	http://www.ebi.ac.uk/interpro/entry/IPR031805
Jabion	63895	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=63895
KEGG_Gene	hsa:63895	http://www.genome.jp/dbget-bin/www_bget?hsa:63895
MIM	108145	http://www.ncbi.nlm.nih.gov/omim/108145
MIM	114300	http://www.ncbi.nlm.nih.gov/omim/114300
MIM	248700	http://www.ncbi.nlm.nih.gov/omim/248700
MIM	613629	http://www.ncbi.nlm.nih.gov/omim/613629
OMA	AENKVPI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AENKVPI
Orphanet	1154	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1154
Orphanet	2461	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=2461
Orphanet	376	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=376
OrthoDB	EOG091G0SD8	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0SD8
PANTHER	PTHR13167	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13167
PSORT	swissprot:PIEZ2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:PIEZ2_HUMAN
PSORT-B	swissprot:PIEZ2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:PIEZ2_HUMAN
PSORT2	swissprot:PIEZ2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:PIEZ2_HUMAN
Pfam	PF12166	http://pfam.xfam.org/family/PF12166
Pfam	PF15917	http://pfam.xfam.org/family/PF15917
PharmGKB	PA134930761	http://www.pharmgkb.org/do/serve?objId=PA134930761&objCls=Gene
Phobius	swissprot:PIEZ2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:PIEZ2_HUMAN
PhylomeDB	Q9H5I5	http://phylomedb.org/?seqid=Q9H5I5
ProteinModelPortal	Q9H5I5	http://www.proteinmodelportal.org/query/uniprot/Q9H5I5
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	16177791	http://www.ncbi.nlm.nih.gov/pubmed/16177791
PubMed	23487782	http://www.ncbi.nlm.nih.gov/pubmed/23487782
PubMed	24726473	http://www.ncbi.nlm.nih.gov/pubmed/24726473
RefSeq	NP_071351	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_071351
RefSeq	XP_011524026	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011524026
STRING	9606.ENSP00000463094	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000463094&targetmode=cogs
TCDB	1.A.75.1	http://www.tcdb.org/search/result.php?tc=1.A.75.1
UCSC	uc002koq	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002koq&org=rat
UniGene	Hs.436902	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.436902
UniProtKB	PIEZ2_HUMAN	http://www.uniprot.org/uniprot/PIEZ2_HUMAN
UniProtKB-AC	Q9H5I5	http://www.uniprot.org/uniprot/Q9H5I5
charge	swissprot:PIEZ2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:PIEZ2_HUMAN
eggNOG	ENOG410YVF6	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YVF6
eggNOG	KOG1893	http://eggnogapi.embl.de/nog_data/html/tree/KOG1893
epestfind	swissprot:PIEZ2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:PIEZ2_HUMAN
garnier	swissprot:PIEZ2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:PIEZ2_HUMAN
helixturnhelix	swissprot:PIEZ2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:PIEZ2_HUMAN
hmoment	swissprot:PIEZ2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:PIEZ2_HUMAN
iep	swissprot:PIEZ2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:PIEZ2_HUMAN
inforesidue	swissprot:PIEZ2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:PIEZ2_HUMAN
neXtProt	NX_Q9H5I5	http://www.nextprot.org/db/entry/NX_Q9H5I5
octanol	swissprot:PIEZ2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:PIEZ2_HUMAN
pepcoil	swissprot:PIEZ2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:PIEZ2_HUMAN
pepdigest	swissprot:PIEZ2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:PIEZ2_HUMAN
pepinfo	swissprot:PIEZ2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:PIEZ2_HUMAN
pepnet	swissprot:PIEZ2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:PIEZ2_HUMAN
pepstats	swissprot:PIEZ2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:PIEZ2_HUMAN
pepwheel	swissprot:PIEZ2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:PIEZ2_HUMAN
pepwindow	swissprot:PIEZ2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:PIEZ2_HUMAN
sigcleave	swissprot:PIEZ2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:PIEZ2_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCJ15_HUMAN	Inward rectifier K(+) channel Kir1.3
# AltName	KCJ15_HUMAN	Inward rectifier K(+) channel Kir4.2
# AltName	KCJ15_HUMAN	Potassium channel, inwardly rectifying subfamily J member 15
# ChiTaRS	KCNJ15	human
# DrugBank	DB01392	Yohimbine
# Ensembl	ENST00000328656	ENSP00000331698; ENSG00000157551
# Ensembl	ENST00000398930	ENSP00000381904; ENSG00000157551
# Ensembl	ENST00000398932	ENSP00000381905; ENSG00000157551
# Ensembl	ENST00000398934	ENSP00000381907; ENSG00000157551
# Ensembl	ENST00000398938	ENSP00000381911; ENSG00000157551
# Ensembl	ENST00000612702	ENSP00000484960; ENSG00000157551
# Ensembl	ENST00000613499	ENSP00000479100; ENSG00000157551
# ExpressionAtlas	Q99712	baseline and differential
# FUNCTION	KCJ15_HUMAN	Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_function	GO:0005242	inward rectifier potassium channel activity; TAS:ProtInc.
# GO_function	GO:0015467	G-protein activated inward rectifier potassium channel activity; TAS:Reactome.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0010107	potassium ion import; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.40.1400	-; 1.
# Genevisible	Q99712	HS
# HGNC	HGNC:6261	KCNJ15
# INTERACTION	KCJ15_HUMAN	Q63ZW7 Inadl (xeno); NbExp=4; IntAct=EBI-7082607, EBI-8366894; 
# IntAct	Q99712	2
# InterPro	IPR003270	K_chnl_inward-rec_Kir1.3
# InterPro	IPR013518	K_chnl_inward-rec_Kir_cyto
# InterPro	IPR014756	Ig_E-set
# InterPro	IPR016449	K_chnl_inward-rec_Kir
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04971	Gastric acid secretion
# MIM	602106	gene
# Organism	KCJ15_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11767	PTHR11767
# PANTHER	PTHR11767:SF20	PTHR11767:SF20
# PIRSF	PIRSF005465	GIRK_kir
# PRINTS	PR01320	KIRCHANNEL
# PRINTS	PR01323	KIR13CHANNEL
# Pfam	PF01007	IRK
# Proteomes	UP000005640	Chromosome 21
# Reactome	R-HSA-1296041	Activation of G protein gated Potassium channels
# Reactome	R-HSA-997272	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
# RecName	KCJ15_HUMAN	ATP-sensitive inward rectifier potassium channel 15
# RefSeq	NP_001263364	NM_001276435.1
# RefSeq	NP_001263365	NM_001276436.1
# RefSeq	NP_001263366	NM_001276437.1
# RefSeq	NP_001263367	NM_001276438.1
# RefSeq	NP_001263368	NM_001276439.1
# RefSeq	NP_002234	NM_002243.4
# RefSeq	NP_733932	NM_170736.2
# RefSeq	NP_733933	NM_170737.2
# RefSeq	XP_005261032	XM_005260975.2
# RefSeq	XP_006724065	XM_006724002.2
# RefSeq	XP_011527862	XM_011529560.2
# RefSeq	XP_011527863	XM_011529561.2
# RefSeq	XP_016883832	XM_017028343.1
# RefSeq	XP_016883833	XM_017028344.1
# RefSeq	XP_016883834	XM_017028345.1
# SIMILARITY	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ15 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCJ15_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Interacts with PATJ. {ECO:0000269|PubMed	9647694}. 
# SUPFAM	SSF81296	SSF81296
# UCSC	uc002ywv	human
# eggNOG	ENOG410XQ62	LUCA
# eggNOG	KOG3827	Eukaryota
BLAST	swissprot:KCJ15_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCJ15_HUMAN
BioCyc	ZFISH:ENSG00000157551-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000157551-MONOMER
COXPRESdb	3772	http://coxpresdb.jp/data/gene/3772.shtml
CleanEx	HS_KCNJ14	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNJ14
CleanEx	HS_KCNJ15	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNJ15
DOI	10.1006/geno.1997.4865	http://dx.doi.org/10.1006/geno.1997.4865
DOI	10.1006/mcne.1998.0679	http://dx.doi.org/10.1006/mcne.1998.0679
DOI	10.1038/35012518	http://dx.doi.org/10.1038/35012518
DOI	10.1074/jbc.272.1.586	http://dx.doi.org/10.1074/jbc.272.1.586
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DrugBank	DB01392	http://www.drugbank.ca/drugs/DB01392
EMBL	AP001434	http://www.ebi.ac.uk/ena/data/view/AP001434
EMBL	BC013327	http://www.ebi.ac.uk/ena/data/view/BC013327
EMBL	CH471079	http://www.ebi.ac.uk/ena/data/view/CH471079
EMBL	CH471079	http://www.ebi.ac.uk/ena/data/view/CH471079
EMBL	D87291	http://www.ebi.ac.uk/ena/data/view/D87291
EMBL	U73191	http://www.ebi.ac.uk/ena/data/view/U73191
EMBL	Y10745	http://www.ebi.ac.uk/ena/data/view/Y10745
Ensembl	ENST00000328656	http://www.ensembl.org/id/ENST00000328656
Ensembl	ENST00000398930	http://www.ensembl.org/id/ENST00000398930
Ensembl	ENST00000398932	http://www.ensembl.org/id/ENST00000398932
Ensembl	ENST00000398934	http://www.ensembl.org/id/ENST00000398934
Ensembl	ENST00000398938	http://www.ensembl.org/id/ENST00000398938
Ensembl	ENST00000612702	http://www.ensembl.org/id/ENST00000612702
Ensembl	ENST00000613499	http://www.ensembl.org/id/ENST00000613499
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005242	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005242
GO_function	GO:0015467	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015467
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0010107	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010107
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.40.1400	http://www.cathdb.info/version/latest/superfamily/2.60.40.1400
GeneCards	KCNJ15	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNJ15
GeneID	3772	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3772
GeneTree	ENSGT00760000118842	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118842
HGNC	HGNC:6261	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6261
HOGENOM	HOG000237326	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237326&db=HOGENOM6
HOVERGEN	HBG006178	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006178&db=HOVERGEN
HPA	HPA016702	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA016702
InParanoid	Q99712	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q99712
IntAct	Q99712	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q99712*
InterPro	IPR003270	http://www.ebi.ac.uk/interpro/entry/IPR003270
InterPro	IPR013518	http://www.ebi.ac.uk/interpro/entry/IPR013518
InterPro	IPR014756	http://www.ebi.ac.uk/interpro/entry/IPR014756
InterPro	IPR016449	http://www.ebi.ac.uk/interpro/entry/IPR016449
Jabion	3772	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3772
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3772	http://www.genome.jp/dbget-bin/www_bget?hsa:3772
KEGG_Orthology	KO:K05008	http://www.genome.jp/dbget-bin/www_bget?KO:K05008
KEGG_Pathway	ko04971	http://www.genome.jp/kegg-bin/show_pathway?ko04971
MIM	602106	http://www.ncbi.nlm.nih.gov/omim/602106
MINT	MINT-103775	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-103775
OMA	CPLAIFT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CPLAIFT
OrthoDB	EOG091G08HC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08HC
PANTHER	PTHR11767	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11767
PANTHER	PTHR11767:SF20	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11767:SF20
PRINTS	PR01320	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01320
PRINTS	PR01323	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01323
PSORT	swissprot:KCJ15_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCJ15_HUMAN
PSORT-B	swissprot:KCJ15_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCJ15_HUMAN
PSORT2	swissprot:KCJ15_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCJ15_HUMAN
Pfam	PF01007	http://pfam.xfam.org/family/PF01007
PharmGKB	PA30046	http://www.pharmgkb.org/do/serve?objId=PA30046&objCls=Gene
Phobius	swissprot:KCJ15_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCJ15_HUMAN
PhylomeDB	Q99712	http://phylomedb.org/?seqid=Q99712
ProteinModelPortal	Q99712	http://www.proteinmodelportal.org/query/uniprot/Q99712
PubMed	10830953	http://www.ncbi.nlm.nih.gov/pubmed/10830953
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	8995301	http://www.ncbi.nlm.nih.gov/pubmed/8995301
PubMed	9299242	http://www.ncbi.nlm.nih.gov/pubmed/9299242
PubMed	9647694	http://www.ncbi.nlm.nih.gov/pubmed/9647694
Reactome	R-HSA-1296041	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296041
Reactome	R-HSA-997272	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-997272
RefSeq	NP_001263364	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001263364
RefSeq	NP_001263365	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001263365
RefSeq	NP_001263366	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001263366
RefSeq	NP_001263367	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001263367
RefSeq	NP_001263368	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001263368
RefSeq	NP_002234	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002234
RefSeq	NP_733932	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_733932
RefSeq	NP_733933	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_733933
RefSeq	XP_005261032	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005261032
RefSeq	XP_006724065	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006724065
RefSeq	XP_011527862	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011527862
RefSeq	XP_011527863	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011527863
RefSeq	XP_016883832	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016883832
RefSeq	XP_016883833	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016883833
RefSeq	XP_016883834	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016883834
SMR	Q99712	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q99712
STRING	9606.ENSP00000331698	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000331698&targetmode=cogs
SUPFAM	SSF81296	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81296
UCSC	uc002ywv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ywv&org=rat
UniGene	Hs.411299	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.411299
UniProtKB	KCJ15_HUMAN	http://www.uniprot.org/uniprot/KCJ15_HUMAN
UniProtKB-AC	Q99712	http://www.uniprot.org/uniprot/Q99712
charge	swissprot:KCJ15_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCJ15_HUMAN
eggNOG	ENOG410XQ62	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ62
eggNOG	KOG3827	http://eggnogapi.embl.de/nog_data/html/tree/KOG3827
epestfind	swissprot:KCJ15_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCJ15_HUMAN
garnier	swissprot:KCJ15_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCJ15_HUMAN
helixturnhelix	swissprot:KCJ15_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCJ15_HUMAN
hmoment	swissprot:KCJ15_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCJ15_HUMAN
iep	swissprot:KCJ15_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCJ15_HUMAN
inforesidue	swissprot:KCJ15_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCJ15_HUMAN
neXtProt	NX_Q99712	http://www.nextprot.org/db/entry/NX_Q99712
octanol	swissprot:KCJ15_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCJ15_HUMAN
pepcoil	swissprot:KCJ15_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCJ15_HUMAN
pepdigest	swissprot:KCJ15_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCJ15_HUMAN
pepinfo	swissprot:KCJ15_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCJ15_HUMAN
pepnet	swissprot:KCJ15_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCJ15_HUMAN
pepstats	swissprot:KCJ15_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCJ15_HUMAN
pepwheel	swissprot:KCJ15_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCJ15_HUMAN
pepwindow	swissprot:KCJ15_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCJ15_HUMAN
sigcleave	swissprot:KCJ15_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCJ15_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AQP10_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96PS8-1; Sequence=Displayed; Name=2; IsoId=Q96PS8-2; Sequence=VSP_010211; 
# AltName	AQP10_HUMAN	Aquaglyceroporin-10
# AltName	AQP10_HUMAN	Small intestine aquaporin
# CCDS	CCDS1065	-. [Q96PS8-1]
# CDD	cd00333	MIP
# DOMAIN	AQP10_HUMAN	Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). 
# Ensembl	ENST00000324978	ENSP00000318355; ENSG00000143595. [Q96PS8-1]
# Ensembl	ENST00000484864	ENSP00000420341; ENSG00000143595. [Q96PS8-2]
# FUNCTION	AQP10_HUMAN	Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol. {ECO 0000269|PubMed 11573934, ECO 0000269|PubMed 12084581}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0015204	urea transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015250	water channel activity; EXP:Reactome.
# GO_function	GO:0015254	glycerol channel activity; EXP:Reactome.
# GO_function	GO:0015265	urea channel activity; EXP:Reactome.
# GO_process	GO:0006833	water transport; TAS:Reactome.
# GO_process	GO:0009636	response to toxic substance; IDA:UniProtKB.
# GO_process	GO:0009992	cellular water homeostasis; IBA:GO_Central.
# GO_process	GO:0034219	carbohydrate transmembrane transport; IBA:GO_Central.
# GO_process	GO:0034220	ion transmembrane transport; IBA:GO_Central.
# GO_process	GO:0071918	urea transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.1080.10	-; 1.
# Genevisible	Q96PS8	HS
# HGNC	HGNC:16029	AQP10
# InterPro	IPR000425	MIP
# InterPro	IPR022357	MIP_CS
# InterPro	IPR023271	Aquaporin-like
# InterPro	IPR026252	Aquaporin_10
# KEGG_Brite	ko04040	Ion channels
# MIM	606578	gene
# Organism	AQP10_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR19139	PTHR19139
# PIR	JC7772	JC7772
# PRINTS	PR00783	MINTRINSICP
# PRINTS	PR02022	AQUAPORIN10M
# PROSITE	PS00221	MIP
# Pfam	PF00230	MIP
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-432047	Passive transport by Aquaporins
# RecName	AQP10_HUMAN	Aquaporin-10
# RefSeq	NP_536354	NM_080429.2. [Q96PS8-1]
# SIMILARITY	Belongs to the MIP/aquaporin (TC 1.A.8) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	AQP10_HUMAN	Membrane; Multi-pass membrane protein. 
# SUPFAM	SSF81338	SSF81338
# TCDB	1.A.8.9	the major intrinsic protein (mip) family
# TIGRFAMs	TIGR00861	MIP
# TISSUE SPECIFICITY	AQP10_HUMAN	Expressed exclusively in duodenum and jejunum. Highest expression in absorptive epithelial cells at the tips of villi in the jejunum. 
# UCSC	uc001feu	human. [Q96PS8-1]
# eggNOG	COG0580	LUCA
# eggNOG	KOG0224	Eukaryota
BLAST	swissprot:AQP10_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AQP10_HUMAN
BioCyc	ZFISH:ENSG00000143595-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000143595-MONOMER
COXPRESdb	89872	http://coxpresdb.jp/data/gene/89872.shtml
CleanEx	HS_AQP10	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AQP10
DOI	10.1006/bbrc.2001.5661	http://dx.doi.org/10.1006/bbrc.2001.5661
DOI	10.1016/S0167-4781(02)00393-7	http://dx.doi.org/10.1016/S0167-4781(02)00393-7
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB066105	http://www.ebi.ac.uk/ena/data/view/AB066105
EMBL	AF159174	http://www.ebi.ac.uk/ena/data/view/AF159174
EMBL	AL354980	http://www.ebi.ac.uk/ena/data/view/AL354980
EMBL	AL354980	http://www.ebi.ac.uk/ena/data/view/AL354980
EMBL	BC069607	http://www.ebi.ac.uk/ena/data/view/BC069607
EMBL	BC074896	http://www.ebi.ac.uk/ena/data/view/BC074896
EMBL	BC074897	http://www.ebi.ac.uk/ena/data/view/BC074897
Ensembl	ENST00000324978	http://www.ensembl.org/id/ENST00000324978
Ensembl	ENST00000484864	http://www.ensembl.org/id/ENST00000484864
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0015204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015204
GO_function	GO:0015250	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015250
GO_function	GO:0015254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015254
GO_function	GO:0015265	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015265
GO_process	GO:0006833	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006833
GO_process	GO:0009636	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009636
GO_process	GO:0009992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009992
GO_process	GO:0034219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034219
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0071918	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071918
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.1080.10	http://www.cathdb.info/version/latest/superfamily/1.20.1080.10
GeneCards	AQP10	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=AQP10
GeneID	89872	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=89872
GeneTree	ENSGT00510000046311	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00510000046311
HGNC	HGNC:16029	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16029
HOGENOM	HOG000288287	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000288287&db=HOGENOM6
HOVERGEN	HBG106057	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG106057&db=HOVERGEN
HPA	HPA065947	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA065947
InParanoid	Q96PS8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96PS8
InterPro	IPR000425	http://www.ebi.ac.uk/interpro/entry/IPR000425
InterPro	IPR022357	http://www.ebi.ac.uk/interpro/entry/IPR022357
InterPro	IPR023271	http://www.ebi.ac.uk/interpro/entry/IPR023271
InterPro	IPR026252	http://www.ebi.ac.uk/interpro/entry/IPR026252
Jabion	89872	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=89872
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:89872	http://www.genome.jp/dbget-bin/www_bget?hsa:89872
KEGG_Orthology	KO:K09878	http://www.genome.jp/dbget-bin/www_bget?KO:K09878
MIM	606578	http://www.ncbi.nlm.nih.gov/omim/606578
OMA	ASDLEMP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ASDLEMP
OrthoDB	EOG091G0FMS	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0FMS
PANTHER	PTHR19139	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19139
PRINTS	PR00783	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00783
PRINTS	PR02022	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR02022
PROSITE	PS00221	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00221
PSORT	swissprot:AQP10_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AQP10_HUMAN
PSORT-B	swissprot:AQP10_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AQP10_HUMAN
PSORT2	swissprot:AQP10_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AQP10_HUMAN
Pfam	PF00230	http://pfam.xfam.org/family/PF00230
PharmGKB	PA24919	http://www.pharmgkb.org/do/serve?objId=PA24919&objCls=Gene
Phobius	swissprot:AQP10_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AQP10_HUMAN
PhylomeDB	Q96PS8	http://phylomedb.org/?seqid=Q96PS8
ProteinModelPortal	Q96PS8	http://www.proteinmodelportal.org/query/uniprot/Q96PS8
PubMed	11573934	http://www.ncbi.nlm.nih.gov/pubmed/11573934
PubMed	12084581	http://www.ncbi.nlm.nih.gov/pubmed/12084581
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
Reactome	R-HSA-432047	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432047
RefSeq	NP_536354	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_536354
STRING	9606.ENSP00000318355	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000318355&targetmode=cogs
SUPFAM	SSF81338	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81338
TCDB	1.A.8.9	http://www.tcdb.org/search/result.php?tc=1.A.8.9
TIGRFAMs	TIGR00861	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00861
UCSC	uc001feu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001feu&org=rat
UniGene	Hs.259048	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.259048
UniProtKB	AQP10_HUMAN	http://www.uniprot.org/uniprot/AQP10_HUMAN
UniProtKB-AC	Q96PS8	http://www.uniprot.org/uniprot/Q96PS8
charge	swissprot:AQP10_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AQP10_HUMAN
eggNOG	COG0580	http://eggnogapi.embl.de/nog_data/html/tree/COG0580
eggNOG	KOG0224	http://eggnogapi.embl.de/nog_data/html/tree/KOG0224
epestfind	swissprot:AQP10_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AQP10_HUMAN
garnier	swissprot:AQP10_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AQP10_HUMAN
helixturnhelix	swissprot:AQP10_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AQP10_HUMAN
hmoment	swissprot:AQP10_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AQP10_HUMAN
iep	swissprot:AQP10_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AQP10_HUMAN
inforesidue	swissprot:AQP10_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AQP10_HUMAN
neXtProt	NX_Q96PS8	http://www.nextprot.org/db/entry/NX_Q96PS8
octanol	swissprot:AQP10_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AQP10_HUMAN
pepcoil	swissprot:AQP10_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AQP10_HUMAN
pepdigest	swissprot:AQP10_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AQP10_HUMAN
pepinfo	swissprot:AQP10_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AQP10_HUMAN
pepnet	swissprot:AQP10_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AQP10_HUMAN
pepstats	swissprot:AQP10_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AQP10_HUMAN
pepwheel	swissprot:AQP10_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AQP10_HUMAN
pepwindow	swissprot:AQP10_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AQP10_HUMAN
sigcleave	swissprot:AQP10_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AQP10_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	4F2_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=P08195-1; Sequence=Displayed; Name=2; IsoId=P08195-2; Sequence=VSP_037907; Note=Initiator Met-1 is removed. Contains a N-acetylserine at position 2. Contains a phosphoserine at position 2. {ECO 0000244|PubMed 19413330, ECO 0000244|PubMed 21406692, ECO 0000244|PubMed 22223895}; Name=3; IsoId=P08195-3; Sequence=VSP_037908; Name=4; IsoId=P08195-4; Sequence=VSP_037909; 
# AltName	4F2_HUMAN	4F2 heavy chain antigen
# AltName	4F2_HUMAN	CD98
# AltName	4F2_HUMAN	Lymphocyte activation antigen 4F2 large subunit
# AltName	4F2_HUMAN	Solute carrier family 3 member 2
# BIOPHYSICOCHEMICAL PROPERTIES	4F2_HUMAN	Kinetic parameters  KM=295 uM for glutamine (in the presence of NaCl) {ECO 0000269|PubMed 10903140}; KM=236 uM for leucine (in the presence of NaCl) {ECO 0000269|PubMed 10903140}; KM=120 uM for arginine (in the presence of NaCl) {ECO 0000269|PubMed 10903140}; KM=138 uM for arginine (in the absence of NaCl) {ECO 0000269|PubMed 10903140}; 
# BioGrid	112411	48
# CAZy	GH13	Glycoside Hydrolase Family 13
# CCDS	CCDS31589	-. [P08195-3]
# CCDS	CCDS31590	-. [P08195-2]
# CCDS	CCDS8039	-. [P08195-1]
# ChiTaRS	SLC3A2	human
# Ensembl	ENST00000338663	ENSP00000340815; ENSG00000168003. [P08195-2]
# Ensembl	ENST00000377889	ENSP00000367121; ENSG00000168003. [P08195-3]
# Ensembl	ENST00000377890	ENSP00000367122; ENSG00000168003. [P08195-1]
# ExpressionAtlas	P08195	baseline and differential
# FUNCTION	4F2_HUMAN	Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier. {ECO 0000269|PubMed 10903140, ECO 0000269|PubMed 11311135, ECO 0000269|PubMed 11389679, ECO 0000269|PubMed 11557028, ECO 0000269|PubMed 11564694, ECO 0000269|PubMed 11742812, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 12225859, ECO 0000269|PubMed 12716892, ECO 0000269|PubMed 14603368, ECO 0000269|PubMed 15769744, ECO 0000269|PubMed 15980244, ECO 0000269|PubMed 9751058, ECO 0000269|PubMed 9829974, ECO 0000269|PubMed 9878049}. 
# GO_component	GO:0005634	nucleus; IDA:HPA.
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0005886	plasma membrane; IDA:HPA.
# GO_component	GO:0005913	cell-cell adherens junction; IDA:BHF-UCL.
# GO_component	GO:0009986	cell surface; IDA:UniProtKB.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0042470	melanosome; IEA:UniProtKB-SubCell.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	4F2_HUMAN	GO 0005432 calcium sodium antiporter activity; TAS UniProtKB.
# GO_function	GO:0003725	double-stranded RNA binding; IDA:MGI.
# GO_function	GO:0003824	catalytic activity; IEA:InterPro.
# GO_function	GO:0015175	neutral amino acid transmembrane transporter activity; ISS:UniProtKB.
# GO_function	GO:0044822	poly(A) RNA binding; IDA:UniProtKB.
# GO_function	GO:0098641	cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
# GO_process	GO:0005975	carbohydrate metabolic process; IEA:InterPro.
# GO_process	GO:0006816	calcium ion transport; NAS:UniProtKB.
# GO_process	GO:0006865	amino acid transport; TAS:UniProtKB.
# GO_process	GO:0015827	tryptophan transport; ISS:UniProtKB.
# GO_process	GO:0016049	cell growth; NAS:UniProtKB.
# GO_process	GO:0043330	response to exogenous dsRNA; IMP:MGI.
# GO_process	GO:0050900	leukocyte migration; TAS:Reactome.
# GO_process	GO:0060356	leucine import; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0003723	RNA binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0005975	carbohydrate metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0040007	growth
# GOslim_process	GO:0048870	cell motility
# Gene3D	2.60.40.1180	-; 1.
# Gene3D	3.20.20.80	-; 1.
# Genevisible	P08195	HS
# HGNC	HGNC:11026	SLC3A2
# INDUCTION	4F2_HUMAN	Expression is induced in resting peripheral blood T- lymphocytes following PHA stimulation. Expression increases at the time of maximal DNA synthesis, in fibroblasts stimulated to divide. Expression and the uptake of leucine is stimulated in mononuclear, cytotrophoblast-like choriocarcinoma cells by combined treatment with PMA and calcium ionophore. {ECO 0000269|PubMed 11742812, ECO 0000269|PubMed 3265470, ECO 0000269|PubMed 3480538}. 
# IntAct	P08195	29
# InterPro	IPR006047	Glyco_hydro_13_cat_dom
# InterPro	IPR013780	Glyco_hydro_b
# InterPro	IPR013781	Glyco_hydro_catalytic_dom
# InterPro	IPR015902	Glyco_hydro_13
# InterPro	IPR017853	Glycoside_hydrolase_SF
# InterPro	IPR031984	SLC3A2_N
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Brite	ko04090	 Cellular antigens
# KEGG_Pathway	ko04974	Protein digestion and absorption
# MASS SPECTROMETRY	Mass=57944.93; Method=MALDI; Range=1-529; Evidence={ECO:0000269|PubMed	11840567}; 
# MIM	158070	gene
# MISCELLANEOUS	4F2_HUMAN	Arginine uptake is inhibited by increasing concentrations of leucine in the presence of Na(+). 
# Organism	4F2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10357	PTHR10357
# PDB	2DH2	X-ray; 2.10 A; A=212-630
# PDB	2DH3	X-ray; 2.80 A; A/B=212-630
# PIR	A28455	SAHU4F
# PTM	4F2_HUMAN	Phosphorylation on Ser-406; Ser-408 or Ser-410 and on Ser-527 or Ser-531 by ecto-protein kinases favors heterotypic cell-cell interactions. {ECO 0000269|PubMed 19065266}. 
# Pfam	PF00128	Alpha-amylase
# Pfam	PF16028	SLC3A2_N
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-210991	Basigin interactions
# Reactome	R-HSA-352230	Amino acid transport across the plasma membrane
# RecName	4F2_HUMAN	4F2 cell-surface antigen heavy chain
# RefSeq	NP_001012680	NM_001012662.2
# RefSeq	NP_001012682	NM_001012664.2. [P08195-3]
# RefSeq	NP_001013269	NM_001013251.2. [P08195-2]
# RefSeq	NP_002385	NM_002394.5. [P08195-1]
# SIMILARITY	Belongs to the SLC3A transporter family. {ECO	0000305}.
# SMART	SM00642	Aamy
# SUBCELLULAR LOCATION	4F2_HUMAN	Apical cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localized to the plasma membrane when associated with SLC7A5 or SLC7A8. Localized to the placental apical membrane. Located selectively at cell-cell adhesion sites (By similarity). Colocalized with SLC7A8/LAT2 at the basolateral membrane of kidney proximal tubules and small intestine epithelia. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity). {ECO 0000250}. 
# SUBUNIT	4F2_HUMAN	Disulfide-linked heterodimer of a glycosylated heavy chain and a non-glycosylated light chain (SLC7A5, SLC7A6, SLCA7A7, SLC7A8, SLC7A10 or SLCA7A11). Colocalizes with cadherins (By similarity). Interacts with FAM57A/CT120 and ICAM1. Constitutively and specifically associates with beta-1 integrins (alpha-2/beta-1, alpha-3/beta-1, alpha-5/beta-1 and alpha-6/beta-1), but minimally with alpha-4/beta-1. {ECO 0000250, ECO 0000269|PubMed 11311135, ECO 0000269|PubMed 11389679, ECO 0000269|PubMed 11557028, ECO 0000269|PubMed 11564694, ECO 0000269|PubMed 11696247, ECO 0000269|PubMed 12225859, ECO 0000269|PubMed 12270127, ECO 0000269|PubMed 12716892, ECO 0000269|PubMed 14603368, ECO 0000269|PubMed 15769744, ECO 0000269|PubMed 17724034, ECO 0000269|PubMed 9751058, ECO 0000269|PubMed 9829974, ECO 0000269|PubMed 9878049}. 
# SUPFAM	SSF51445	SSF51445
# TCDB	8.A.9.2	the rbat transport accessory protein (rbat) family
# TISSUE SPECIFICITY	4F2_HUMAN	Expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta was significantly stronger at full-term than at the mid- trimester stage. Expressed in HUVECS and at low levels in resting peripheral blood T-lymphocytes and quiescent fibroblasts. Also expressed in fetal liver and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line C2BBe1. {ECO 0000269|PubMed 11389679, ECO 0000269|PubMed 11557028, ECO 0000269|PubMed 11742812, ECO 0000269|PubMed 12716892, ECO 0000269|PubMed 14603368, ECO 0000269|PubMed 15980244, ECO 0000269|PubMed 16496379, ECO 0000269|PubMed 3265470, ECO 0000269|PubMed 3480538}. 
# UCSC	uc001nwd	human. [P08195-1]
# eggNOG	COG0366	LUCA
# eggNOG	KOG0471	Eukaryota
BLAST	swissprot:4F2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:4F2_HUMAN
BioCyc	MetaCyc:ENSG00000168003-MONOMER	http://biocyc.org/getid?id=MetaCyc:ENSG00000168003-MONOMER
BioCyc	ZFISH:ENSG00000168003-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000168003-MONOMER
COXPRESdb	6520	http://coxpresdb.jp/data/gene/6520.shtml
CleanEx	HS_SLC3A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC3A2
DOI	10.1002/1615-9861(200202)2:2<212::AID-PROT212>3.0.CO	http://dx.doi.org/10.1002/1615-9861(200202)2:2<212::AID-PROT212>3.0.CO
DOI	10.1002/ijc.21866	http://dx.doi.org/10.1002/ijc.21866
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/S0005-2736(01)00384-4	http://dx.doi.org/10.1016/S0005-2736(01)00384-4
DOI	10.1016/S0005-2736(02)00516-3	http://dx.doi.org/10.1016/S0005-2736(02)00516-3
DOI	10.1016/S0006-291X(02)02227-1	http://dx.doi.org/10.1016/S0006-291X(02)02227-1
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr0502065	http://dx.doi.org/10.1021/pr0502065
DOI	10.1021/pr060363j	http://dx.doi.org/10.1021/pr060363j
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/26246	http://dx.doi.org/10.1038/26246
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1038/nbt.1532	http://dx.doi.org/10.1038/nbt.1532
DOI	10.1038/nbt827	http://dx.doi.org/10.1038/nbt827
DOI	10.1042/0264-6021:3560719	http://dx.doi.org/10.1042/0264-6021:3560719
DOI	10.1042/BJ20020841	http://dx.doi.org/10.1042/BJ20020841
DOI	10.1042/bj3490787	http://dx.doi.org/10.1042/bj3490787
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1073/pnas.1413825111	http://dx.doi.org/10.1073/pnas.1413825111
DOI	10.1073/pnas.84.18.6526	http://dx.doi.org/10.1073/pnas.84.18.6526
DOI	10.1073/pnas.84.24.9204	http://dx.doi.org/10.1073/pnas.84.24.9204
DOI	10.1074/jbc.273.49.32437	http://dx.doi.org/10.1074/jbc.273.49.32437
DOI	10.1074/jbc.M302777200	http://dx.doi.org/10.1074/jbc.M302777200
DOI	10.1074/jbc.M413164200	http://dx.doi.org/10.1074/jbc.M413164200
DOI	10.1074/jbc.M704524200	http://dx.doi.org/10.1074/jbc.M704524200
DOI	10.1074/mcp.M111.015131	http://dx.doi.org/10.1074/mcp.M111.015131
DOI	10.1074/mcp.M800504-MCP200	http://dx.doi.org/10.1074/mcp.M800504-MCP200
DOI	10.1093/emboj/18.1.49	http://dx.doi.org/10.1093/emboj/18.1.49
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1113/eph8802647	http://dx.doi.org/10.1113/eph8802647
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1128/MCB.8.9.3809	http://dx.doi.org/10.1128/MCB.8.9.3809
DOI	10.1167/iovs.04-1175	http://dx.doi.org/10.1167/iovs.04-1175
DOI	10.1186/1472-2091-2-10	http://dx.doi.org/10.1186/1472-2091-2-10
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1210/en.142.10.4339	http://dx.doi.org/10.1210/en.142.10.4339
DOI	10.1371/journal.pone.0003895	http://dx.doi.org/10.1371/journal.pone.0003895
EMBL	AB018010	http://www.ebi.ac.uk/ena/data/view/AB018010
EMBL	AP001160	http://www.ebi.ac.uk/ena/data/view/AP001160
EMBL	BC001061	http://www.ebi.ac.uk/ena/data/view/BC001061
EMBL	BC003000	http://www.ebi.ac.uk/ena/data/view/BC003000
EMBL	BE794697	http://www.ebi.ac.uk/ena/data/view/BE794697
EMBL	J02769	http://www.ebi.ac.uk/ena/data/view/J02769
EMBL	J02939	http://www.ebi.ac.uk/ena/data/view/J02939
EMBL	J03569	http://www.ebi.ac.uk/ena/data/view/J03569
EMBL	M21898	http://www.ebi.ac.uk/ena/data/view/M21898
EMBL	M21899	http://www.ebi.ac.uk/ena/data/view/M21899
EMBL	M21900	http://www.ebi.ac.uk/ena/data/view/M21900
EMBL	M21901	http://www.ebi.ac.uk/ena/data/view/M21901
EMBL	M21902	http://www.ebi.ac.uk/ena/data/view/M21902
EMBL	M21903	http://www.ebi.ac.uk/ena/data/view/M21903
EMBL	M21904	http://www.ebi.ac.uk/ena/data/view/M21904
Ensembl	ENST00000338663	http://www.ensembl.org/id/ENST00000338663
Ensembl	ENST00000377889	http://www.ensembl.org/id/ENST00000377889
Ensembl	ENST00000377890	http://www.ensembl.org/id/ENST00000377890
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005913
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0042470	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042470
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0003725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003725
GO_function	GO:0003824	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003824
GO_function	GO:0005432	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005432
GO_function	GO:0015175	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015175
GO_function	GO:0044822	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044822
GO_function	GO:0098641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098641
GO_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GO_process	GO:0015827	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015827
GO_process	GO:0016049	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016049
GO_process	GO:0043330	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043330
GO_process	GO:0050900	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050900
GO_process	GO:0060356	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060356
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0003723	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0040007	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040007
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
Gene3D	2.60.40.1180	http://www.cathdb.info/version/latest/superfamily/2.60.40.1180
Gene3D	3.20.20.80	http://www.cathdb.info/version/latest/superfamily/3.20.20.80
GeneCards	SLC3A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC3A2
GeneID	6520	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6520
GeneTree	ENSGT00860000133843	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00860000133843
HGNC	HGNC:11026	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11026
HOGENOM	HOG000233529	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233529&db=HOGENOM6
HOVERGEN	HBG000023	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000023&db=HOVERGEN
HPA	CAB010455	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB010455
HPA	HPA017980	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA017980
InParanoid	P08195	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08195
IntAct	P08195	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08195*
InterPro	IPR006047	http://www.ebi.ac.uk/interpro/entry/IPR006047
InterPro	IPR013780	http://www.ebi.ac.uk/interpro/entry/IPR013780
InterPro	IPR013781	http://www.ebi.ac.uk/interpro/entry/IPR013781
InterPro	IPR015902	http://www.ebi.ac.uk/interpro/entry/IPR015902
InterPro	IPR017853	http://www.ebi.ac.uk/interpro/entry/IPR017853
InterPro	IPR031984	http://www.ebi.ac.uk/interpro/entry/IPR031984
Jabion	6520	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6520
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Brite	ko04090	http://www.genome.jp/dbget-bin/www_bget?ko04090
KEGG_Gene	hsa:6520	http://www.genome.jp/dbget-bin/www_bget?hsa:6520
KEGG_Orthology	KO:K06519	http://www.genome.jp/dbget-bin/www_bget?KO:K06519
KEGG_Pathway	ko04974	http://www.genome.jp/kegg-bin/show_pathway?ko04974
MIM	158070	http://www.ncbi.nlm.nih.gov/omim/158070
MINT	MINT-4999018	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4999018
PANTHER	PTHR10357	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10357
PDB	2DH2	http://www.ebi.ac.uk/pdbe-srv/view/entry/2DH2
PDB	2DH3	http://www.ebi.ac.uk/pdbe-srv/view/entry/2DH3
PDBsum	2DH2	http://www.ebi.ac.uk/pdbsum/2DH2
PDBsum	2DH3	http://www.ebi.ac.uk/pdbsum/2DH3
PSORT	swissprot:4F2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:4F2_HUMAN
PSORT-B	swissprot:4F2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:4F2_HUMAN
PSORT2	swissprot:4F2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:4F2_HUMAN
Pfam	PF00128	http://pfam.xfam.org/family/PF00128
Pfam	PF16028	http://pfam.xfam.org/family/PF16028
PharmGKB	PA35894	http://www.pharmgkb.org/do/serve?objId=PA35894&objCls=Gene
Phobius	swissprot:4F2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:4F2_HUMAN
PhylomeDB	P08195	http://phylomedb.org/?seqid=P08195
ProteinModelPortal	P08195	http://www.proteinmodelportal.org/query/uniprot/P08195
PubMed	10903140	http://www.ncbi.nlm.nih.gov/pubmed/10903140
PubMed	11311135	http://www.ncbi.nlm.nih.gov/pubmed/11311135
PubMed	11389679	http://www.ncbi.nlm.nih.gov/pubmed/11389679
PubMed	11557028	http://www.ncbi.nlm.nih.gov/pubmed/11557028
PubMed	11564694	http://www.ncbi.nlm.nih.gov/pubmed/11564694
PubMed	11696247	http://www.ncbi.nlm.nih.gov/pubmed/11696247
PubMed	11742812	http://www.ncbi.nlm.nih.gov/pubmed/11742812
PubMed	11840567	http://www.ncbi.nlm.nih.gov/pubmed/11840567
PubMed	12117417	http://www.ncbi.nlm.nih.gov/pubmed/12117417
PubMed	12225859	http://www.ncbi.nlm.nih.gov/pubmed/12225859
PubMed	12270127	http://www.ncbi.nlm.nih.gov/pubmed/12270127
PubMed	12716892	http://www.ncbi.nlm.nih.gov/pubmed/12716892
PubMed	12754519	http://www.ncbi.nlm.nih.gov/pubmed/12754519
PubMed	14603368	http://www.ncbi.nlm.nih.gov/pubmed/14603368
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15769744	http://www.ncbi.nlm.nih.gov/pubmed/15769744
PubMed	15980244	http://www.ncbi.nlm.nih.gov/pubmed/15980244
PubMed	16335952	http://www.ncbi.nlm.nih.gov/pubmed/16335952
PubMed	16496379	http://www.ncbi.nlm.nih.gov/pubmed/16496379
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	17081065	http://www.ncbi.nlm.nih.gov/pubmed/17081065
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	17724034	http://www.ncbi.nlm.nih.gov/pubmed/17724034
PubMed	19065266	http://www.ncbi.nlm.nih.gov/pubmed/19065266
PubMed	19139490	http://www.ncbi.nlm.nih.gov/pubmed/19139490
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	19349973	http://www.ncbi.nlm.nih.gov/pubmed/19349973
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	22223895	http://www.ncbi.nlm.nih.gov/pubmed/22223895
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25114211	http://www.ncbi.nlm.nih.gov/pubmed/25114211
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	3036867	http://www.ncbi.nlm.nih.gov/pubmed/3036867
PubMed	3265470	http://www.ncbi.nlm.nih.gov/pubmed/3265470
PubMed	3476959	http://www.ncbi.nlm.nih.gov/pubmed/3476959
PubMed	3480538	http://www.ncbi.nlm.nih.gov/pubmed/3480538
PubMed	9751058	http://www.ncbi.nlm.nih.gov/pubmed/9751058
PubMed	9829974	http://www.ncbi.nlm.nih.gov/pubmed/9829974
PubMed	9878049	http://www.ncbi.nlm.nih.gov/pubmed/9878049
Reactome	R-HSA-210991	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-210991
Reactome	R-HSA-352230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-352230
RefSeq	NP_001012680	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001012680
RefSeq	NP_001012682	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001012682
RefSeq	NP_001013269	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001013269
RefSeq	NP_002385	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002385
SMART	SM00642	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00642
SMR	P08195	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08195
STRING	9606.ENSP00000367123	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000367123&targetmode=cogs
SUPFAM	SSF51445	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51445
TCDB	8.A.9.2	http://www.tcdb.org/search/result.php?tc=8.A.9.2
UCSC	uc001nwd	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001nwd&org=rat
UniGene	Hs.502769	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.502769
UniProtKB	4F2_HUMAN	http://www.uniprot.org/uniprot/4F2_HUMAN
UniProtKB-AC	P08195	http://www.uniprot.org/uniprot/P08195
charge	swissprot:4F2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:4F2_HUMAN
eggNOG	COG0366	http://eggnogapi.embl.de/nog_data/html/tree/COG0366
eggNOG	KOG0471	http://eggnogapi.embl.de/nog_data/html/tree/KOG0471
epestfind	swissprot:4F2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:4F2_HUMAN
garnier	swissprot:4F2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:4F2_HUMAN
helixturnhelix	swissprot:4F2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:4F2_HUMAN
hmoment	swissprot:4F2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:4F2_HUMAN
iep	swissprot:4F2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:4F2_HUMAN
inforesidue	swissprot:4F2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:4F2_HUMAN
neXtProt	NX_P08195	http://www.nextprot.org/db/entry/NX_P08195
octanol	swissprot:4F2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:4F2_HUMAN
pepcoil	swissprot:4F2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:4F2_HUMAN
pepdigest	swissprot:4F2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:4F2_HUMAN
pepinfo	swissprot:4F2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:4F2_HUMAN
pepnet	swissprot:4F2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:4F2_HUMAN
pepstats	swissprot:4F2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:4F2_HUMAN
pepwheel	swissprot:4F2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:4F2_HUMAN
pepwindow	swissprot:4F2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:4F2_HUMAN
sigcleave	swissprot:4F2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:4F2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNJ3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P48549-1; Sequence=Displayed; Name=2; IsoId=P48549-2; Sequence=VSP_045432, VSP_045433; 
# AltName	KCNJ3_HUMAN	Inward rectifier K(+) channel Kir3.1
# AltName	KCNJ3_HUMAN	Potassium channel, inwardly rectifying subfamily J member 3
# BioGrid	109962	5
# CCDS	CCDS2200	-. [P48549-1]
# CCDS	CCDS58733	-. [P48549-2]
# ChiTaRS	KCNJ3	human
# DrugBank	DB00898	Ethanol
# DrugBank	DB01159	Halothane
# Ensembl	ENST00000295101	ENSP00000295101; ENSG00000162989. [P48549-1]
# Ensembl	ENST00000544049	ENSP00000438410; ENSG00000162989. [P48549-2]
# FUNCTION	KCNJ3_HUMAN	This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008076	voltage-gated potassium channel complex; TAS:ProtInc.
# GO_component	GO:0009897	external side of plasma membrane; IEA:Ensembl.
# GO_component	GO:0030315	T-tubule; IEA:Ensembl.
# GO_function	GO:0015467	G-protein activated inward rectifier potassium channel activity; TAS:Reactome.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0010107	potassium ion import; IBA:GO_Central.
# GO_process	GO:0051602	response to electrical stimulus; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.40.1400	-; 1.
# Genevisible	P48549	HS
# HGNC	HGNC:6264	KCNJ3
# InterPro	IPR003274	K_chnl_inward-rec_Kir3.1
# InterPro	IPR013518	K_chnl_inward-rec_Kir_cyto
# InterPro	IPR014756	Ig_E-set
# InterPro	IPR016449	K_chnl_inward-rec_Kir
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04713	Circadian entrainment
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04724	Glutamatergic synapse
# KEGG_Pathway	ko04725	Cholinergic synapse
# KEGG_Pathway	ko04726	Serotonergic synapse
# KEGG_Pathway	ko04728	Dopaminergic synapse
# KEGG_Pathway	ko05032	Morphine addiction
# MIM	601534	gene
# Organism	KCNJ3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11767	PTHR11767
# PIR	G02468	G02468
# PRINTS	PR01320	KIRCHANNEL
# PRINTS	PR01327	KIR31CHANNEL
# Pfam	PF01007	IRK
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-1296041	Activation of G protein gated Potassium channels
# Reactome	R-HSA-997272	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
# RecName	KCNJ3_HUMAN	G protein-activated inward rectifier potassium channel 1
# RefSeq	NP_001247437	NM_001260508.1. [P48549-2]
# RefSeq	NP_001247438	NM_001260509.1
# RefSeq	NP_001247439	NM_001260510.1
# RefSeq	NP_002230	NM_002239.3. [P48549-1]
# SIMILARITY	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCNJ3_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger (By similarity). {ECO	0000250}. 
# SUPFAM	SSF81296	SSF81296
# TCDB	1.A.2.1.12	inward rectifier k(+) channel (irk-c) family
# UCSC	uc002tyv	human. [P48549-1]
# eggNOG	ENOG410XQ62	LUCA
# eggNOG	KOG3827	Eukaryota
BLAST	swissprot:KCNJ3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNJ3_HUMAN
BioCyc	ZFISH:ENSG00000162989-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000162989-MONOMER
COXPRESdb	3760	http://coxpresdb.jp/data/gene/3760.shtml
CleanEx	HS_KCNJ3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNJ3
DOI	10.1016/0169-328X(95)00349-W	http://dx.doi.org/10.1016/0169-328X(95)00349-W
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M005338200	http://dx.doi.org/10.1074/jbc.M005338200
DOI	10.1085/jgp.107.3.381	http://dx.doi.org/10.1085/jgp.107.3.381
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01159	http://www.drugbank.ca/drugs/DB01159
EMBL	AC061961	http://www.ebi.ac.uk/ena/data/view/AC061961
EMBL	AC093633	http://www.ebi.ac.uk/ena/data/view/AC093633
EMBL	AC107060	http://www.ebi.ac.uk/ena/data/view/AC107060
EMBL	AK293824	http://www.ebi.ac.uk/ena/data/view/AK293824
EMBL	BC022495	http://www.ebi.ac.uk/ena/data/view/BC022495
EMBL	GU074515	http://www.ebi.ac.uk/ena/data/view/GU074515
EMBL	U39196	http://www.ebi.ac.uk/ena/data/view/U39196
EMBL	U50964	http://www.ebi.ac.uk/ena/data/view/U50964
Ensembl	ENST00000295101	http://www.ensembl.org/id/ENST00000295101
Ensembl	ENST00000544049	http://www.ensembl.org/id/ENST00000544049
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0009897	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009897
GO_component	GO:0030315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030315
GO_function	GO:0015467	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015467
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0010107	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010107
GO_process	GO:0051602	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051602
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.40.1400	http://www.cathdb.info/version/latest/superfamily/2.60.40.1400
GeneCards	KCNJ3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNJ3
GeneID	3760	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3760
GeneTree	ENSGT00760000118842	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118842
HGNC	HGNC:6264	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6264
HOGENOM	HOG000237325	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237325&db=HOGENOM6
HOVERGEN	HBG006178	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006178&db=HOVERGEN
HPA	HPA024231	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA024231
InParanoid	P48549	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P48549
InterPro	IPR003274	http://www.ebi.ac.uk/interpro/entry/IPR003274
InterPro	IPR013518	http://www.ebi.ac.uk/interpro/entry/IPR013518
InterPro	IPR014756	http://www.ebi.ac.uk/interpro/entry/IPR014756
InterPro	IPR016449	http://www.ebi.ac.uk/interpro/entry/IPR016449
Jabion	3760	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3760
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3760	http://www.genome.jp/dbget-bin/www_bget?hsa:3760
KEGG_Orthology	KO:K04997	http://www.genome.jp/dbget-bin/www_bget?KO:K04997
KEGG_Pathway	ko04713	http://www.genome.jp/kegg-bin/show_pathway?ko04713
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
KEGG_Pathway	ko04725	http://www.genome.jp/kegg-bin/show_pathway?ko04725
KEGG_Pathway	ko04726	http://www.genome.jp/kegg-bin/show_pathway?ko04726
KEGG_Pathway	ko04728	http://www.genome.jp/kegg-bin/show_pathway?ko04728
KEGG_Pathway	ko05032	http://www.genome.jp/kegg-bin/show_pathway?ko05032
MIM	601534	http://www.ncbi.nlm.nih.gov/omim/601534
OMA	NQPPPEK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NQPPPEK
OrthoDB	EOG091G08HC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08HC
PANTHER	PTHR11767	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11767
PRINTS	PR01320	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01320
PRINTS	PR01327	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01327
PSORT	swissprot:KCNJ3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNJ3_HUMAN
PSORT-B	swissprot:KCNJ3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNJ3_HUMAN
PSORT2	swissprot:KCNJ3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNJ3_HUMAN
Pfam	PF01007	http://pfam.xfam.org/family/PF01007
PharmGKB	PA215	http://www.pharmgkb.org/do/serve?objId=PA215&objCls=Gene
Phobius	swissprot:KCNJ3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNJ3_HUMAN
PhylomeDB	P48549	http://phylomedb.org/?seqid=P48549
ProteinModelPortal	P48549	http://www.proteinmodelportal.org/query/uniprot/P48549
PubMed	10889209	http://www.ncbi.nlm.nih.gov/pubmed/10889209
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	8804710	http://www.ncbi.nlm.nih.gov/pubmed/8804710
PubMed	8868049	http://www.ncbi.nlm.nih.gov/pubmed/8868049
Reactome	R-HSA-1296041	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296041
Reactome	R-HSA-997272	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-997272
RefSeq	NP_001247437	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001247437
RefSeq	NP_001247438	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001247438
RefSeq	NP_001247439	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001247439
RefSeq	NP_002230	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002230
SMR	P48549	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P48549
STRING	9606.ENSP00000295101	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000295101&targetmode=cogs
SUPFAM	SSF81296	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81296
TCDB	1.A.2.1.12	http://www.tcdb.org/search/result.php?tc=1.A.2.1.12
UCSC	uc002tyv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002tyv&org=rat
UniGene	Hs.591606	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.591606
UniProtKB	KCNJ3_HUMAN	http://www.uniprot.org/uniprot/KCNJ3_HUMAN
UniProtKB-AC	P48549	http://www.uniprot.org/uniprot/P48549
charge	swissprot:KCNJ3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNJ3_HUMAN
eggNOG	ENOG410XQ62	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ62
eggNOG	KOG3827	http://eggnogapi.embl.de/nog_data/html/tree/KOG3827
epestfind	swissprot:KCNJ3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNJ3_HUMAN
garnier	swissprot:KCNJ3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNJ3_HUMAN
helixturnhelix	swissprot:KCNJ3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNJ3_HUMAN
hmoment	swissprot:KCNJ3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNJ3_HUMAN
iep	swissprot:KCNJ3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNJ3_HUMAN
inforesidue	swissprot:KCNJ3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNJ3_HUMAN
neXtProt	NX_P48549	http://www.nextprot.org/db/entry/NX_P48549
octanol	swissprot:KCNJ3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNJ3_HUMAN
pepcoil	swissprot:KCNJ3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNJ3_HUMAN
pepdigest	swissprot:KCNJ3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNJ3_HUMAN
pepinfo	swissprot:KCNJ3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNJ3_HUMAN
pepnet	swissprot:KCNJ3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNJ3_HUMAN
pepstats	swissprot:KCNJ3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNJ3_HUMAN
pepwheel	swissprot:KCNJ3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNJ3_HUMAN
pepwindow	swissprot:KCNJ3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNJ3_HUMAN
sigcleave	swissprot:KCNJ3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNJ3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	PK2L1_HUMAN	Event=Alternative splicing; Named isoforms=5; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q9P0L9-1; Sequence=Displayed; Name=2; Synonyms=PKDLdel15, PCL-TS, Testis isoform; IsoId=Q9P0L9-2; Sequence=VSP_004730, VSP_004731; Name=3; Synonyms=PKDLdel5; IsoId=Q9P0L9-3; Sequence=VSP_004729; Name=4; Synonyms=PKDLdel456; IsoId=Q9P0L9-4; Sequence=VSP_004728; Note=Unusual intron exon spliced junction.; Name=5; Synonyms=PCL-LV, Liver isoform; IsoId=Q9P0L9-5; Sequence=VSP_053718; 
# AltName	PK2L1_HUMAN	Polycystin-2 homolog
# AltName	PK2L1_HUMAN	Polycystin-2L1
# AltName	PK2L1_HUMAN	Polycystin-L
# AltName	PK2L1_HUMAN	Polycystin-L1
# BioGrid	114499	2
# CAUTION	PK2L1_HUMAN	PKD1L3 and PKD2L1 have been defined as sour taste receptor in gustatory cells based on a number of indirect evidences in mouse. Some data confirm this hypothesis in human  in 2 patients with sour ageusia that are unresponsive to sour stimuli, but show normal responses to bitter, sweet, and salty stimuli, expression of PKD1L3 and PKD2L1 is absent in the anterior part of the tongue (PubMed 19812697). However, a number of experiments have recently shown that the sour taste receptor activity is probably indirect. {ECO 0000305|PubMed 19812697}.
# CCDS	CCDS7492	-. [Q9P0L9-1]
# DOMAIN	PK2L1_HUMAN	The EF-hand domain probably mediates calcium-binding. It is not required for channel activation (PubMed 11959145). {ECO 0000269|PubMed 11959145}. 
# ENZYME REGULATION	PK2L1_HUMAN	The calcium channel is gated following an off- response property by acid  gated open after the removal of acid stimulus, but not during acid application. {ECO 0000269|PubMed 18535624, ECO 0000269|PubMed 19464260, ECO 0000269|PubMed 22420714}. 
# Ensembl	ENST00000318222	ENSP00000325296; ENSG00000107593. [Q9P0L9-1]
# ExpressionAtlas	Q9P0L9	baseline and differential
# FUNCTION	PK2L1_HUMAN	Pore-forming subunit of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD1L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect. {ECO 0000269|PubMed 10517637, ECO 0000269|PubMed 19812697, ECO 0000269|PubMed 23212381, ECO 0000269|PubMed 24336289}. 
# GO_component	GO:0005783	endoplasmic reticulum; ISS:BHF-UCL.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0009986	cell surface; IEA:Ensembl.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0034704	calcium channel complex; IDA:UniProtKB.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:BHF-UCL.
# GO_component	GO:0043235	receptor complex; ISS:BHF-UCL.
# GO_component	GO:0060170	ciliary membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0097730	non-motile cilium; IDA:UniProtKB.
# GO_function	GO:0005227	calcium activated cation channel activity; IDA:BHF-UCL.
# GO_function	GO:0005261	cation channel activity; IDA:BHF-UCL.
# GO_function	GO:0005262	calcium channel activity; IDA:UniProtKB.
# GO_function	GO:0005272	sodium channel activity; IDA:BHF-UCL.
# GO_function	GO:0005509	calcium ion binding; IDA:UniProtKB.
# GO_function	GO:0008092	cytoskeletal protein binding; IPI:UniProtKB.
# GO_function	GO:0015269	calcium-activated potassium channel activity; IDA:BHF-UCL.
# GO_function	GO:0033040	sour taste receptor activity; IEA:Ensembl.
# GO_function	GO:0042802	identical protein binding; ISS:BHF-UCL.
# GO_function	GO:0051371	muscle alpha-actinin binding; IPI:BHF-UCL.
# GO_function	GO:0051393	alpha-actinin binding; IPI:BHF-UCL.
# GO_process	GO:0001581	detection of chemical stimulus involved in sensory perception of sour taste; ISS:BHF-UCL.
# GO_process	GO:0006812	cation transport; ISS:BHF-UCL.
# GO_process	GO:0007224	smoothened signaling pathway; ISS:UniProtKB.
# GO_process	GO:0035725	sodium ion transmembrane transport; IDA:BHF-UCL.
# GO_process	GO:0050915	sensory perception of sour taste; IMP:UniProtKB.
# GO_process	GO:0050982	detection of mechanical stimulus; IBA:GO_Central.
# GO_process	GO:0070207	protein homotrimerization; IDA:UniProtKB.
# GO_process	GO:0071468	cellular response to acidic pH; ISS:BHF-UCL.
# GO_process	GO:0071805	potassium ion transmembrane transport; IDA:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0005929	cilium
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0008092	cytoskeletal protein binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.10.238.10	-; 1.
# Genevisible	Q9P0L9	HS
# HGNC	HGNC:9011	PKD2L1
# InterPro	IPR003915	PKD_2
# InterPro	IPR011992	EF-hand-dom_pair
# InterPro	IPR013122	PKD1_2_channel
# KEGG_Brite	ko04040	Ion channels
# MIM	604532	gene
# Organism	PK2L1_HUMAN	Homo sapiens (Human)
# PDB	3TE3	X-ray; 2.69 A; A/B/C/D/E/F=699-737
# PDB	4GIF	X-ray; 2.80 A; A=699-743
# PRINTS	PR01433	POLYCYSTIN2
# Pfam	PF08016	PKD_channel
# Proteomes	UP000005640	Chromosome 10
# RecName	PK2L1_HUMAN	Polycystic kidney disease 2-like 1 protein
# RefSeq	NP_001240766	NM_001253837.1
# RefSeq	NP_057196	NM_016112.2. [Q9P0L9-1]
# SIMILARITY	Belongs to the polycystin family. {ECO	0000305}. 
# SIMILARITY	Contains 1 EF-hand domain. {ECO	0000305}. 
# SUBCELLULAR LOCATION	PK2L1_HUMAN	Cell projection, cilium membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum {ECO 0000250}. Note=Interaction with PKD1 or PKD1L3 is required for localization to the cell membrane. 
# SUBUNIT	PK2L1_HUMAN	Homotrimer; trimerization is independent of calcium- binding. Calcium channels are probably composed of 3 subunit of PKD2L1 and 1 subunit of some PKD1 protein (PKD1, PKD1L1, PKD1L2 or PKDL3). Interacts with PKD1. Interacts with PKD1L1; to form ciliary calcium channel. Interacts with PKD1L3, to form putative sour taste receptor. Interacts with RACK1; inhibits the channel activity possibly by impairing localization to the cell membrane. {ECO 0000269|PubMed 20408813, ECO 0000269|PubMed 20538909, ECO 0000269|PubMed 22174419, ECO 0000269|PubMed 22193359, ECO 0000269|PubMed 23212381, ECO 0000269|PubMed 24336289}. 
# TCDB	1.A.5.1	the polycystin cation channel (pcc) family
# TISSUE SPECIFICITY	PK2L1_HUMAN	Expressed in adult heart, skeletal muscle, brain, spleen, testis, retina and liver. According to PubMed 9748274, expressed at high levels in fetal tissues, including kidney and liver, and down-regulated in adult tissues. According to PubMed 10602361, expressed in fetal brain, but not expressed in fetal lung, liver or kidney. Isoform 4 appears to be expressed only in transformed lymphoblasts. {ECO 0000269|PubMed 10602361, ECO 0000269|PubMed 9748274}. 
# UCSC	uc001kqx	human. [Q9P0L9-1]
# eggNOG	ENOG410XTGE	LUCA
# eggNOG	KOG3599	Eukaryota
BLAST	swissprot:PK2L1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:PK2L1_HUMAN
BioCyc	ZFISH:ENSG00000107593-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000107593-MONOMER
COXPRESdb	9033	http://coxpresdb.jp/data/gene/9033.shtml
CleanEx	HS_PKD2L1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_PKD2L1
DOI	10.1006/geno.1998.5618	http://dx.doi.org/10.1006/geno.1998.5618
DOI	10.1007/s003350010009	http://dx.doi.org/10.1007/s003350010009
DOI	10.1016/S0165-6147(00)01832-0	http://dx.doi.org/10.1016/S0165-6147(00)01832-0
DOI	10.1016/j.bbapap.2011.12.002	http://dx.doi.org/10.1016/j.bbapap.2011.12.002
DOI	10.1016/j.bbrc.2009.05.069	http://dx.doi.org/10.1016/j.bbrc.2009.05.069
DOI	10.1038/43907	http://dx.doi.org/10.1038/43907
DOI	10.1038/embor.2008.89	http://dx.doi.org/10.1038/embor.2008.89
DOI	10.1038/nature02462	http://dx.doi.org/10.1038/nature02462
DOI	10.1038/nature12832	http://dx.doi.org/10.1038/nature12832
DOI	10.1038/ncomms2257	http://dx.doi.org/10.1038/ncomms2257
DOI	10.1038/sj.ejhg.5200383	http://dx.doi.org/10.1038/sj.ejhg.5200383
DOI	10.1042/BJ20091843	http://dx.doi.org/10.1042/BJ20091843
DOI	10.1074/jbc.273.40.25967	http://dx.doi.org/10.1074/jbc.273.40.25967
DOI	10.1074/jbc.M111.305854	http://dx.doi.org/10.1074/jbc.M111.305854
DOI	10.1096/fj.10-162925	http://dx.doi.org/10.1096/fj.10-162925
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1742-4658.2012.08566.x	http://dx.doi.org/10.1111/j.1742-4658.2012.08566.x
DOI	10.1371/journal.pone.0007347	http://dx.doi.org/10.1371/journal.pone.0007347
EMBL	AF053316	http://www.ebi.ac.uk/ena/data/view/AF053316
EMBL	AF073481	http://www.ebi.ac.uk/ena/data/view/AF073481
EMBL	AF094827	http://www.ebi.ac.uk/ena/data/view/AF094827
EMBL	AF153459	http://www.ebi.ac.uk/ena/data/view/AF153459
EMBL	AF153460	http://www.ebi.ac.uk/ena/data/view/AF153460
EMBL	AF153461	http://www.ebi.ac.uk/ena/data/view/AF153461
EMBL	AF153462	http://www.ebi.ac.uk/ena/data/view/AF153462
EMBL	AF153463	http://www.ebi.ac.uk/ena/data/view/AF153463
EMBL	AF153464	http://www.ebi.ac.uk/ena/data/view/AF153464
EMBL	AF153465	http://www.ebi.ac.uk/ena/data/view/AF153465
EMBL	AF153466	http://www.ebi.ac.uk/ena/data/view/AF153466
EMBL	AF153467	http://www.ebi.ac.uk/ena/data/view/AF153467
EMBL	AF153468	http://www.ebi.ac.uk/ena/data/view/AF153468
EMBL	AF153469	http://www.ebi.ac.uk/ena/data/view/AF153469
EMBL	AF153470	http://www.ebi.ac.uk/ena/data/view/AF153470
EMBL	AF153471	http://www.ebi.ac.uk/ena/data/view/AF153471
EMBL	AF153472	http://www.ebi.ac.uk/ena/data/view/AF153472
EMBL	AF153473	http://www.ebi.ac.uk/ena/data/view/AF153473
EMBL	AF153474	http://www.ebi.ac.uk/ena/data/view/AF153474
EMBL	AL139819	http://www.ebi.ac.uk/ena/data/view/AL139819
EMBL	BC025665	http://www.ebi.ac.uk/ena/data/view/BC025665
EMBL	CH471066	http://www.ebi.ac.uk/ena/data/view/CH471066
Ensembl	ENST00000318222	http://www.ensembl.org/id/ENST00000318222
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0034704	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034704
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_component	GO:0043235	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043235
GO_component	GO:0060170	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060170
GO_component	GO:0097730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097730
GO_function	GO:0005227	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005227
GO_function	GO:0005261	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005261
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0005272	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005272
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0008092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GO_function	GO:0015269	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015269
GO_function	GO:0033040	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033040
GO_function	GO:0042802	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802
GO_function	GO:0051371	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051371
GO_function	GO:0051393	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051393
GO_process	GO:0001581	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001581
GO_process	GO:0006812	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006812
GO_process	GO:0007224	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007224
GO_process	GO:0035725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035725
GO_process	GO:0050915	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050915
GO_process	GO:0050982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050982
GO_process	GO:0070207	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070207
GO_process	GO:0071468	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071468
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0005929	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005929
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0008092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.10.238.10	http://www.cathdb.info/version/latest/superfamily/1.10.238.10
GeneCards	PKD2L1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=PKD2L1
GeneID	9033	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9033
GeneTree	ENSGT00700000104221	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00700000104221
HGNC	HGNC:9011	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:9011
HOGENOM	HOG000230858	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230858&db=HOGENOM6
HOVERGEN	HBG014945	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG014945&db=HOVERGEN
HPA	CAB022621	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB022621
InParanoid	Q9P0L9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9P0L9
IntAct	Q9P0L9	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9P0L9*
InterPro	IPR003915	http://www.ebi.ac.uk/interpro/entry/IPR003915
InterPro	IPR011992	http://www.ebi.ac.uk/interpro/entry/IPR011992
InterPro	IPR013122	http://www.ebi.ac.uk/interpro/entry/IPR013122
Jabion	9033	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9033
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:9033	http://www.genome.jp/dbget-bin/www_bget?hsa:9033
KEGG_Orthology	KO:K04990	http://www.genome.jp/dbget-bin/www_bget?KO:K04990
MIM	604532	http://www.ncbi.nlm.nih.gov/omim/604532
MINT	MINT-3973148	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3973148
OMA	FIYYENM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FIYYENM
OrthoDB	EOG091G034F	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G034F
PDB	3TE3	http://www.ebi.ac.uk/pdbe-srv/view/entry/3TE3
PDB	4GIF	http://www.ebi.ac.uk/pdbe-srv/view/entry/4GIF
PDBsum	3TE3	http://www.ebi.ac.uk/pdbsum/3TE3
PDBsum	4GIF	http://www.ebi.ac.uk/pdbsum/4GIF
PRINTS	PR01433	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01433
PSORT	swissprot:PK2L1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:PK2L1_HUMAN
PSORT-B	swissprot:PK2L1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:PK2L1_HUMAN
PSORT2	swissprot:PK2L1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:PK2L1_HUMAN
Pfam	PF08016	http://pfam.xfam.org/family/PF08016
PharmGKB	PA33344	http://www.pharmgkb.org/do/serve?objId=PA33344&objCls=Gene
Phobius	swissprot:PK2L1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:PK2L1_HUMAN
PhylomeDB	Q9P0L9	http://phylomedb.org/?seqid=Q9P0L9
ProteinModelPortal	Q9P0L9	http://www.proteinmodelportal.org/query/uniprot/Q9P0L9
PubMed	10517637	http://www.ncbi.nlm.nih.gov/pubmed/10517637
PubMed	10602361	http://www.ncbi.nlm.nih.gov/pubmed/10602361
PubMed	10602992	http://www.ncbi.nlm.nih.gov/pubmed/10602992
PubMed	11698076	http://www.ncbi.nlm.nih.gov/pubmed/11698076
PubMed	11959145	http://www.ncbi.nlm.nih.gov/pubmed/11959145
PubMed	15164054	http://www.ncbi.nlm.nih.gov/pubmed/15164054
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18535624	http://www.ncbi.nlm.nih.gov/pubmed/18535624
PubMed	19464260	http://www.ncbi.nlm.nih.gov/pubmed/19464260
PubMed	19812697	http://www.ncbi.nlm.nih.gov/pubmed/19812697
PubMed	20408813	http://www.ncbi.nlm.nih.gov/pubmed/20408813
PubMed	20538909	http://www.ncbi.nlm.nih.gov/pubmed/20538909
PubMed	22174419	http://www.ncbi.nlm.nih.gov/pubmed/22174419
PubMed	22193359	http://www.ncbi.nlm.nih.gov/pubmed/22193359
PubMed	22420714	http://www.ncbi.nlm.nih.gov/pubmed/22420714
PubMed	23212381	http://www.ncbi.nlm.nih.gov/pubmed/23212381
PubMed	24336289	http://www.ncbi.nlm.nih.gov/pubmed/24336289
PubMed	9748274	http://www.ncbi.nlm.nih.gov/pubmed/9748274
PubMed	9878261	http://www.ncbi.nlm.nih.gov/pubmed/9878261
RefSeq	NP_001240766	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001240766
RefSeq	NP_057196	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_057196
SMR	Q9P0L9	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9P0L9
STRING	9606.ENSP00000325296	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000325296&targetmode=cogs
TCDB	1.A.5.1	http://www.tcdb.org/search/result.php?tc=1.A.5.1
UCSC	uc001kqx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001kqx&org=rat
UniGene	Hs.159241	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.159241
UniProtKB	PK2L1_HUMAN	http://www.uniprot.org/uniprot/PK2L1_HUMAN
UniProtKB-AC	Q9P0L9	http://www.uniprot.org/uniprot/Q9P0L9
charge	swissprot:PK2L1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:PK2L1_HUMAN
eggNOG	ENOG410XTGE	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XTGE
eggNOG	KOG3599	http://eggnogapi.embl.de/nog_data/html/tree/KOG3599
epestfind	swissprot:PK2L1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:PK2L1_HUMAN
garnier	swissprot:PK2L1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:PK2L1_HUMAN
helixturnhelix	swissprot:PK2L1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:PK2L1_HUMAN
hmoment	swissprot:PK2L1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:PK2L1_HUMAN
iep	swissprot:PK2L1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:PK2L1_HUMAN
inforesidue	swissprot:PK2L1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:PK2L1_HUMAN
neXtProt	NX_Q9P0L9	http://www.nextprot.org/db/entry/NX_Q9P0L9
octanol	swissprot:PK2L1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:PK2L1_HUMAN
pepcoil	swissprot:PK2L1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:PK2L1_HUMAN
pepdigest	swissprot:PK2L1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:PK2L1_HUMAN
pepinfo	swissprot:PK2L1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:PK2L1_HUMAN
pepnet	swissprot:PK2L1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:PK2L1_HUMAN
pepstats	swissprot:PK2L1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:PK2L1_HUMAN
pepwheel	swissprot:PK2L1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:PK2L1_HUMAN
pepwindow	swissprot:PK2L1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:PK2L1_HUMAN
sigcleave	swissprot:PK2L1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:PK2L1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y6N1-1; Sequence=Displayed; Name=2; IsoId=Q9Y6N1-2; Sequence=VSP_046360; Note=No experimental confirmation available. Ref.4 (BI600359) sequence is in conflict in position: 223	V->G. {ECO:0000305}; 
# BioGrid	107746	10
# CCDS	CCDS11583	-. [Q9Y6N1-1]
# CCDS	CCDS58579	-. [Q9Y6N1-2]
# Ensembl	ENST00000299335	ENSP00000299335; ENSG00000166260. [Q9Y6N1-1]
# Ensembl	ENST00000572558	ENSP00000459302; ENSG00000166260. [Q9Y6N1-2]
# Ensembl	ENST00000576370	ENSP00000459901; ENSG00000166260. [Q9Y6N1-1]
# ExpressionAtlas	Q9Y6N1	baseline and differential
# FUNCTION	COX11_HUMAN	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I. {ECO 0000250}. 
# GO_component	GO:0005739	mitochondrion; TAS:ProtInc.
# GO_component	GO:0005743	mitochondrial inner membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0004129	cytochrome-c oxidase activity; TAS:ProtInc.
# GO_function	GO:0005507	copper ion binding; IBA:GO_Central.
# GO_function	GO:0009055	electron carrier activity; TAS:UniProtKB.
# GO_process	GO:0007585	respiratory gaseous exchange; TAS:ProtInc.
# GO_process	GO:0008535	respiratory chain complex IV assembly; TAS:ProtInc.
# GO_process	GO:0009060	aerobic respiration; IBA:GO_Central.
# GO_process	GO:0033132	negative regulation of glucokinase activity; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0008150	biological_process
# Gene3D	2.60.370.10	-; 1.
# Genevisible	Q9Y6N1	HS
# HAMAP	MF_00155	CtaG
# HGNC	HGNC:2261	COX11
# IntAct	Q9Y6N1	10
# InterPro	IPR007533	Cyt_c_oxidase_assmbl_CtaG
# InterPro	IPR023471	CtaG/Cox11_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# MIM	603648	gene
# Organism	COX11_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR21320	PTHR21320
# Pfam	PF04442	CtaG_Cox11
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-5628897	TP53 Regulates Metabolic Genes
# Reactome	R-HSA-611105	Respiratory electron transport
# RecName	COX11_HUMAN	Cytochrome c oxidase assembly protein COX11, mitochondrial
# RefSeq	NP_004366	NM_004375.4. [Q9Y6N1-1]
# RefSeq	XP_011522644	XM_011524342.2. [Q9Y6N1-1]
# RefSeq	XP_016879681	XM_017024192.1. [Q9Y6N1-1]
# RefSeq	XP_016879682	XM_017024193.1. [Q9Y6N1-1]
# RefSeq	XP_016879683	XM_017024194.1. [Q9Y6N1-2]
# RefSeq	XP_016879684	XM_017024195.1. [Q9Y6N1-2]
# RefSeq	XP_016879685	XM_017024196.1. [Q9Y6N1-2]
# SIMILARITY	Belongs to the COX11/CtaG family. {ECO	0000305}.
# SUBCELLULAR LOCATION	COX11_HUMAN	Mitochondrion inner membrane {ECO 0000269|PubMed 9878253}; Single-pass membrane protein {ECO 0000269|PubMed 9878253}; Intermembrane side {ECO 0000269|PubMed 9878253}. 
# SUBUNIT	Interacts with CNNM4/ACDP4. {ECO:0000269|PubMed	15840172}. 
# SUPFAM	SSF110111	SSF110111
# TISSUE SPECIFICITY	Ubiquitous. {ECO:0000269|PubMed	9878253}. 
# UCSC	uc010wng	human. [Q9Y6N1-1]
# eggNOG	COG3175	LUCA
# eggNOG	KOG2540	Eukaryota
BLAST	swissprot:COX11_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:COX11_HUMAN
BioCyc	ZFISH:ENSG00000166260-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000166260-MONOMER
COG	COG3175	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3175
COXPRESdb	1353	http://coxpresdb.jp/data/gene/1353.shtml
CleanEx	HS_COX11	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_COX11
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/geno.1998.5580	http://dx.doi.org/10.1006/geno.1998.5580
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1744-8069-1-15	http://dx.doi.org/10.1186/1744-8069-1-15
EMBL	AC007485	http://www.ebi.ac.uk/ena/data/view/AC007485
EMBL	AC090824	http://www.ebi.ac.uk/ena/data/view/AC090824
EMBL	AF044321	http://www.ebi.ac.uk/ena/data/view/AF044321
EMBL	BC005895	http://www.ebi.ac.uk/ena/data/view/BC005895
EMBL	BI600359	http://www.ebi.ac.uk/ena/data/view/BI600359
EMBL	CH471109	http://www.ebi.ac.uk/ena/data/view/CH471109
EMBL	CH471109	http://www.ebi.ac.uk/ena/data/view/CH471109
EMBL	CR541837	http://www.ebi.ac.uk/ena/data/view/CR541837
EMBL	U79270	http://www.ebi.ac.uk/ena/data/view/U79270
Ensembl	ENST00000299335	http://www.ensembl.org/id/ENST00000299335
Ensembl	ENST00000572558	http://www.ensembl.org/id/ENST00000572558
Ensembl	ENST00000576370	http://www.ensembl.org/id/ENST00000576370
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0004129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004129
GO_function	GO:0005507	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005507
GO_function	GO:0009055	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055
GO_process	GO:0007585	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007585
GO_process	GO:0008535	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008535
GO_process	GO:0009060	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009060
GO_process	GO:0033132	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033132
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	2.60.370.10	http://www.cathdb.info/version/latest/superfamily/2.60.370.10
GeneCards	COX11	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=COX11
GeneID	1353	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1353
GeneTree	ENSGT00390000007512	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000007512
HAMAP	MF_00155	http://hamap.expasy.org/unirule/MF_00155
HGNC	HGNC:2261	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2261
HOGENOM	HOG000264965	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264965&db=HOGENOM6
HOVERGEN	HBG051085	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051085&db=HOVERGEN
HPA	HPA044020	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA044020
InParanoid	Q9Y6N1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y6N1
IntAct	Q9Y6N1	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9Y6N1*
InterPro	IPR007533	http://www.ebi.ac.uk/interpro/entry/IPR007533
InterPro	IPR023471	http://www.ebi.ac.uk/interpro/entry/IPR023471
Jabion	1353	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1353
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Gene	hsa:1353	http://www.genome.jp/dbget-bin/www_bget?hsa:1353
KEGG_Orthology	KO:K02258	http://www.genome.jp/dbget-bin/www_bget?KO:K02258
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
MIM	603648	http://www.ncbi.nlm.nih.gov/omim/603648
OMA	RMARVDT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RMARVDT
OrthoDB	EOG091G0J14	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0J14
PANTHER	PTHR21320	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21320
PSORT	swissprot:COX11_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:COX11_HUMAN
PSORT-B	swissprot:COX11_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:COX11_HUMAN
PSORT2	swissprot:COX11_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:COX11_HUMAN
Pfam	PF04442	http://pfam.xfam.org/family/PF04442
PharmGKB	PA26777	http://www.pharmgkb.org/do/serve?objId=PA26777&objCls=Gene
Phobius	swissprot:COX11_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:COX11_HUMAN
PhylomeDB	Q9Y6N1	http://phylomedb.org/?seqid=Q9Y6N1
ProteinModelPortal	Q9Y6N1	http://www.proteinmodelportal.org/query/uniprot/Q9Y6N1
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15840172	http://www.ncbi.nlm.nih.gov/pubmed/15840172
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	9110174	http://www.ncbi.nlm.nih.gov/pubmed/9110174
PubMed	9878253	http://www.ncbi.nlm.nih.gov/pubmed/9878253
Reactome	R-HSA-5628897	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5628897
Reactome	R-HSA-611105	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-611105
RefSeq	NP_004366	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004366
RefSeq	XP_011522644	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011522644
RefSeq	XP_016879681	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016879681
RefSeq	XP_016879682	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016879682
RefSeq	XP_016879683	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016879683
RefSeq	XP_016879684	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016879684
RefSeq	XP_016879685	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016879685
STRING	9606.ENSP00000299335	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000299335&targetmode=cogs
STRING	COG3175	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3175&targetmode=cogs
SUPFAM	SSF110111	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF110111
UCSC	uc010wng	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010wng&org=rat
UniGene	Hs.591171	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.591171
UniGene	Hs.657992	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.657992
UniProtKB	COX11_HUMAN	http://www.uniprot.org/uniprot/COX11_HUMAN
UniProtKB-AC	Q9Y6N1	http://www.uniprot.org/uniprot/Q9Y6N1
charge	swissprot:COX11_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:COX11_HUMAN
eggNOG	COG3175	http://eggnogapi.embl.de/nog_data/html/tree/COG3175
eggNOG	KOG2540	http://eggnogapi.embl.de/nog_data/html/tree/KOG2540
epestfind	swissprot:COX11_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:COX11_HUMAN
garnier	swissprot:COX11_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:COX11_HUMAN
helixturnhelix	swissprot:COX11_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:COX11_HUMAN
hmoment	swissprot:COX11_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:COX11_HUMAN
iep	swissprot:COX11_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:COX11_HUMAN
inforesidue	swissprot:COX11_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:COX11_HUMAN
neXtProt	NX_Q9Y6N1	http://www.nextprot.org/db/entry/NX_Q9Y6N1
octanol	swissprot:COX11_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:COX11_HUMAN
pepcoil	swissprot:COX11_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:COX11_HUMAN
pepdigest	swissprot:COX11_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:COX11_HUMAN
pepinfo	swissprot:COX11_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:COX11_HUMAN
pepnet	swissprot:COX11_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:COX11_HUMAN
pepstats	swissprot:COX11_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:COX11_HUMAN
pepwheel	swissprot:COX11_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:COX11_HUMAN
pepwindow	swissprot:COX11_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:COX11_HUMAN
sigcleave	swissprot:COX11_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:COX11_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S39A6_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13433-1; Sequence=Displayed; Name=2; IsoId=Q13433-2; Sequence=VSP_014309, VSP_014310, VSP_014311; Note=No experimental confirmation available.; 
# AltName	S39A6_HUMAN	Estrogen-regulated protein LIV-1
# AltName	S39A6_HUMAN	Solute carrier family 39 member 6
# AltName	S39A6_HUMAN	Zrt- and Irt-like protein 6
# BioGrid	117332	14
# CCDS	CCDS42428	-. [Q13433-1]
# CCDS	CCDS45854	-. [Q13433-2]
# ChiTaRS	SLC39A6	human
# Ensembl	ENST00000269187	ENSP00000269187; ENSG00000141424. [Q13433-1]
# Ensembl	ENST00000440549	ENSP00000401139; ENSG00000141424. [Q13433-2]
# Ensembl	ENST00000590986	ENSP00000465915; ENSG00000141424. [Q13433-1]
# ExpressionAtlas	Q13433	baseline and differential
# FUNCTION	S39A6_HUMAN	May act as a zinc-influx transporter. {ECO 0000269|PubMed 12839489}. 
# GO_component	GO:0005783	endoplasmic reticulum; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0009986	cell surface; IDA:UniProtKB.
# GO_component	GO:0031258	lamellipodium membrane; IDA:UniProtKB.
# GO_function	GO:0005385	zinc ion transmembrane transporter activity; IDA:BHF-UCL.
# GO_process	GO:0006882	cellular zinc ion homeostasis; IDA:BHF-UCL.
# GO_process	GO:0071577	zinc II ion transmembrane transport; IMP:UniProtKB.
# GO_process	GO:0071578	zinc II ion transmembrane import; IDA:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q13433	HS
# HGNC	HGNC:18607	SLC39A6
# INDUCTION	Up-regulated by estrogen in breast cancer cells lines. {ECO:0000269|PubMed	2903103}. 
# IntAct	Q13433	4
# InterPro	IPR003689	ZIP
# KEGG_Brite	ko02001	Solute carrier family
# MIM	608731	gene
# Organism	S39A6_HUMAN	Homo sapiens (Human)
# PIR	G02273	G02273
# PTM	S39A6_HUMAN	N-glycosylated. {ECO 0000269|PubMed 12839489, ECO 0000269|PubMed 19349973}. 
# Pfam	PF02535	Zip; 2
# Proteomes	UP000005640	Chromosome 18
# Reactome	R-HSA-442380	Zinc influx into cells by the SLC39 gene family
# RecName	S39A6_HUMAN	Zinc transporter ZIP6
# RefSeq	NP_001092876	NM_001099406.1. [Q13433-2]
# RefSeq	NP_036451	NM_012319.3
# RefSeq	XP_011524202	XM_011525900.1. [Q13433-1]
# RefSeq	XP_011524203	XM_011525901.1. [Q13433-1]
# SEQUENCE CAUTION	Sequence=BAG61161.1; Type=Erroneous initiation; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the ZIP transporter (TC 2.A.5) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S39A6_HUMAN	Cell membrane {ECO 0000269|PubMed 12839489}; Multi-pass membrane protein {ECO 0000269|PubMed 12839489}. 
# TCDB	2.A.5.4.13	the zinc (zn(2+))-iron (fe(2+)) permease (zip) family
# TISSUE SPECIFICITY	Highly expressed in the breast, prostate, placenta, kidney, pituitary and corpus callosum. Weakly expressed in heart and intestine. Also highly expressed in cells derived from an adenocarcinoma of the cervix and lung carcinoma. {ECO:0000269|PubMed	12839489}. 
# UCSC	uc002kzj	human. [Q13433-1]
# WEB RESOURCE	S39A6_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/SLC39A6ID44189ch18q12.html";
# eggNOG	COG0428	LUCA
# eggNOG	KOG2693	Eukaryota
BLAST	swissprot:S39A6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S39A6_HUMAN
BioCyc	ZFISH:ENSG00000141424-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000141424-MONOMER
COXPRESdb	25800	http://coxpresdb.jp/data/gene/25800.shtml
CleanEx	HS_SLC39A6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC39A6
DOI	10.1016/0303-7207(88)90105-0	http://dx.doi.org/10.1016/0303-7207(88)90105-0
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature03983	http://dx.doi.org/10.1038/nature03983
DOI	10.1038/nbt.1532	http://dx.doi.org/10.1038/nbt.1532
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/BJ20030478	http://dx.doi.org/10.1042/BJ20030478
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1110/ps.04682504	http://dx.doi.org/10.1110/ps.04682504
EMBL	AC091060	http://www.ebi.ac.uk/ena/data/view/AC091060
EMBL	AK299102	http://www.ebi.ac.uk/ena/data/view/AK299102
EMBL	AK304079	http://www.ebi.ac.uk/ena/data/view/AK304079
EMBL	BC008317	http://www.ebi.ac.uk/ena/data/view/BC008317
EMBL	BC039498	http://www.ebi.ac.uk/ena/data/view/BC039498
EMBL	CH471088	http://www.ebi.ac.uk/ena/data/view/CH471088
EMBL	U41060	http://www.ebi.ac.uk/ena/data/view/U41060
Ensembl	ENST00000269187	http://www.ensembl.org/id/ENST00000269187
Ensembl	ENST00000440549	http://www.ensembl.org/id/ENST00000440549
Ensembl	ENST00000590986	http://www.ensembl.org/id/ENST00000590986
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0031258	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031258
GO_function	GO:0005385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005385
GO_process	GO:0006882	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006882
GO_process	GO:0071577	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071577
GO_process	GO:0071578	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071578
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC39A6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC39A6
GeneID	25800	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25800
GeneTree	ENSGT00760000119115	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119115
HGNC	HGNC:18607	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18607
HOGENOM	HOG000013093	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000013093&db=HOGENOM6
HOVERGEN	HBG055748	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG055748&db=HOVERGEN
HPA	HPA042377	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042377
InParanoid	Q13433	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q13433
IntAct	Q13433	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q13433*
InterPro	IPR003689	http://www.ebi.ac.uk/interpro/entry/IPR003689
Jabion	25800	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=25800
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:25800	http://www.genome.jp/dbget-bin/www_bget?hsa:25800
KEGG_Orthology	KO:K14712	http://www.genome.jp/dbget-bin/www_bget?KO:K14712
MIM	608731	http://www.ncbi.nlm.nih.gov/omim/608731
OMA	HRPEHAS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HRPEHAS
OrthoDB	EOG091G02WM	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02WM
PSORT	swissprot:S39A6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S39A6_HUMAN
PSORT-B	swissprot:S39A6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S39A6_HUMAN
PSORT2	swissprot:S39A6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S39A6_HUMAN
Pfam	PF02535	http://pfam.xfam.org/family/PF02535
PharmGKB	PA134905551	http://www.pharmgkb.org/do/serve?objId=PA134905551&objCls=Gene
Phobius	swissprot:S39A6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S39A6_HUMAN
PhylomeDB	Q13433	http://phylomedb.org/?seqid=Q13433
ProteinModelPortal	Q13433	http://www.proteinmodelportal.org/query/uniprot/Q13433
PubMed	12839489	http://www.ncbi.nlm.nih.gov/pubmed/12839489
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15340161	http://www.ncbi.nlm.nih.gov/pubmed/15340161
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16177791	http://www.ncbi.nlm.nih.gov/pubmed/16177791
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19349973	http://www.ncbi.nlm.nih.gov/pubmed/19349973
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	2903103	http://www.ncbi.nlm.nih.gov/pubmed/2903103
Reactome	R-HSA-442380	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442380
RefSeq	NP_001092876	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001092876
RefSeq	NP_036451	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_036451
RefSeq	XP_011524202	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011524202
RefSeq	XP_011524203	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011524203
STRING	9606.ENSP00000269187	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000269187&targetmode=cogs
TCDB	2.A.5.4.13	http://www.tcdb.org/search/result.php?tc=2.A.5.4.13
UCSC	uc002kzj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002kzj&org=rat
UniGene	Hs.79136	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.79136
UniProtKB	S39A6_HUMAN	http://www.uniprot.org/uniprot/S39A6_HUMAN
UniProtKB-AC	Q13433	http://www.uniprot.org/uniprot/Q13433
charge	swissprot:S39A6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S39A6_HUMAN
eggNOG	COG0428	http://eggnogapi.embl.de/nog_data/html/tree/COG0428
eggNOG	KOG2693	http://eggnogapi.embl.de/nog_data/html/tree/KOG2693
epestfind	swissprot:S39A6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S39A6_HUMAN
garnier	swissprot:S39A6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S39A6_HUMAN
helixturnhelix	swissprot:S39A6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S39A6_HUMAN
hmoment	swissprot:S39A6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S39A6_HUMAN
iep	swissprot:S39A6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S39A6_HUMAN
inforesidue	swissprot:S39A6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S39A6_HUMAN
neXtProt	NX_Q13433	http://www.nextprot.org/db/entry/NX_Q13433
octanol	swissprot:S39A6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S39A6_HUMAN
pepcoil	swissprot:S39A6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S39A6_HUMAN
pepdigest	swissprot:S39A6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S39A6_HUMAN
pepinfo	swissprot:S39A6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S39A6_HUMAN
pepnet	swissprot:S39A6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S39A6_HUMAN
pepstats	swissprot:S39A6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S39A6_HUMAN
pepwheel	swissprot:S39A6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S39A6_HUMAN
pepwindow	swissprot:S39A6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S39A6_HUMAN
sigcleave	swissprot:S39A6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S39A6_HUMAN
## Database	ID	URL or Descriptions
# AltName	COX3_HUMAN	Cytochrome c oxidase polypeptide III
# BioGrid	110617	7
# CDD	cd01665	Cyt_c_Oxidase_III
# DISEASE	COX3_HUMAN	Leber hereditary optic neuropathy (LHON) [MIM 535000]  A maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes. {ECO 0000269|PubMed 8240356}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	COX3_HUMAN	Mitochondrial complex IV deficiency (MT-C4D) [MIM 220110]  A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, exercise intolerance, developmental delay, delayed motor development and mental retardation. Some affected individuals manifest a fatal hypertrophic cardiomyopathy resulting in neonatal death. A subset of patients manifest Leigh syndrome. {ECO 0000269|PubMed 8630495}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	COX3_HUMAN	Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome (MELAS) [MIM 540000]  Genetically heterogeneous disorder, characterized by episodic vomiting, seizures, and recurrent cerebral insults resembling strokes and causing hemiparesis, hemianopsia, or cortical blindness. {ECO 0000269|PubMed 18587274, ECO 0000269|PubMed 7496173}. Note=The disease may be caused by mutations affecting the gene represented in this entry. 
# DISEASE	COX3_HUMAN	Recurrent myoglobinuria mitochondrial (RM-MT) [MIM 550500]  Recurrent myoglobinuria is characterized by recurrent attacks of rhabdomyolysis (necrosis or disintegration of skeletal muscle) associated with muscle pain and weakness, and followed by excretion of myoglobin in the urine. {ECO 0000269|PubMed 8630495}. Note=The gene represented in this entry may be involved in disease pathogenesis. 
# DrugBank	DB02659	Cholic Acid
# Ensembl	ENST00000362079	ENSP00000354982; ENSG00000198938
# ExpressionAtlas	P00414	baseline and differential
# FUNCTION	COX3_HUMAN	Subunits I, II and III form the functional core of the enzyme complex. 
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0045277	respiratory chain complex IV; IDA:UniProtKB.
# GO_function	GO:0004129	cytochrome-c oxidase activity; IEA:InterPro.
# GO_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen; TAS:Reactome.
# GO_process	GO:0008535	respiratory chain complex IV assembly; IMP:UniProtKB.
# GO_process	GO:0019646	aerobic electron transport chain; IEA:InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# GOslim_process	GO:0006461	protein complex assembly
# Gene3D	1.20.120.80	-; 1.
# Genevisible	P00414	HS
# HGNC	HGNC:7422	MT-CO3
# INTERACTION	COX3_HUMAN	P37840 SNCA; NbExp=3; IntAct=EBI-3932264, EBI-985879; 
# IntAct	P00414	8
# InterPro	IPR000298	Cyt_c_oxidase-like_su3
# InterPro	IPR013833	Cyt_c_oxidase_su3_a-hlx
# InterPro	IPR024791	Cyt_c/ubiquinol_Oxase_su3
# InterPro	IPR033945	Cyt_c_oxase_su3_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Disease	H00068	[Neurodegenerative disease] Leber hereditary optic atrophy (LHON)
# KEGG_Disease	H01355	[Inherited metabolic disease; Mitochondrial disease] Kearns-Sayre Syndrome
# KEGG_Disease	H01368:[Inherited metabolic disease; Mitochondrial disease] Leber Hereditary Optic Neuropathy (LHON) [DS	H00068]
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	220110	phenotype
# MIM	516050	gene
# MIM	535000	phenotype
# MIM	540000	phenotype
# MIM	550500	phenotype
# Organism	COX3_HUMAN	Homo sapiens (Human)
# Orphanet	104	Leber hereditary optic neuropathy
# Orphanet	254905	Isolated cytochrome C oxidase deficiency
# Orphanet	255210	Maternally-inherited Leigh syndrome
# Orphanet	550	MELAS
# Orphanet	99845	Genetic recurrent myoglobinuria
# PANTHER	PTHR11403	PTHR11403
# PIR	A00482	OTHU3
# PROSITE	PS50253	COX3
# Pfam	PF00510	COX3
# Proteomes	UP000005640	Mitochondrion
# Reactome	R-HSA-5628897	TP53 Regulates Metabolic Genes
# Reactome	R-HSA-611105	Respiratory electron transport
# RecName	COX3_HUMAN	Cytochrome c oxidase subunit 3
# RefSeq	YP_003024032	NC_012920.1
# SIMILARITY	Belongs to the cytochrome c oxidase subunit 3 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	COX3_HUMAN	Mitochondrion inner membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUPFAM	SSF81452	SSF81452
# TCDB	3.D.4.11	the proton-translocating cytochrome oxidase (cox) superfamily
# eggNOG	COG1845	LUCA
# eggNOG	KOG4664	Eukaryota
BLAST	swissprot:COX3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:COX3_HUMAN
BioCyc	ZFISH:HS00028-MONOMER	http://biocyc.org/getid?id=ZFISH:HS00028-MONOMER
COG	COG1845	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1845
COXPRESdb	4514	http://coxpresdb.jp/data/gene/4514.shtml
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/bbrc.1993.2321	http://dx.doi.org/10.1006/bbrc.1993.2321
DOI	10.1007/BF00206061	http://dx.doi.org/10.1007/BF00206061
DOI	10.1016/0960-8966(94)00079-O	http://dx.doi.org/10.1016/0960-8966(94)00079-O
DOI	10.1038/290457a0	http://dx.doi.org/10.1038/290457a0
DOI	10.1038/ng0496-410	http://dx.doi.org/10.1038/ng0496-410
DOI	10.1093/nar/26.4.967	http://dx.doi.org/10.1093/nar/26.4.967
DOI	10.1186/1471-2164-7-151	http://dx.doi.org/10.1186/1471-2164-7-151
DOI	10.3858/emm.2008.40.3.354	http://dx.doi.org/10.3858/emm.2008.40.3.354
DrugBank	DB02659	http://www.drugbank.ca/drugs/DB02659
EMBL	AF004341	http://www.ebi.ac.uk/ena/data/view/AF004341
EMBL	DQ654394	http://www.ebi.ac.uk/ena/data/view/DQ654394
EMBL	DQ654395	http://www.ebi.ac.uk/ena/data/view/DQ654395
EMBL	DQ654396	http://www.ebi.ac.uk/ena/data/view/DQ654396
EMBL	DQ654397	http://www.ebi.ac.uk/ena/data/view/DQ654397
EMBL	DQ654398	http://www.ebi.ac.uk/ena/data/view/DQ654398
EMBL	DQ654399	http://www.ebi.ac.uk/ena/data/view/DQ654399
EMBL	DQ654400	http://www.ebi.ac.uk/ena/data/view/DQ654400
EMBL	DQ654401	http://www.ebi.ac.uk/ena/data/view/DQ654401
EMBL	DQ654402	http://www.ebi.ac.uk/ena/data/view/DQ654402
EMBL	DQ654403	http://www.ebi.ac.uk/ena/data/view/DQ654403
EMBL	DQ654404	http://www.ebi.ac.uk/ena/data/view/DQ654404
EMBL	DQ654405	http://www.ebi.ac.uk/ena/data/view/DQ654405
EMBL	DQ654406	http://www.ebi.ac.uk/ena/data/view/DQ654406
EMBL	DQ654407	http://www.ebi.ac.uk/ena/data/view/DQ654407
EMBL	DQ654408	http://www.ebi.ac.uk/ena/data/view/DQ654408
EMBL	DQ654409	http://www.ebi.ac.uk/ena/data/view/DQ654409
EMBL	DQ654410	http://www.ebi.ac.uk/ena/data/view/DQ654410
EMBL	DQ654411	http://www.ebi.ac.uk/ena/data/view/DQ654411
EMBL	DQ654412	http://www.ebi.ac.uk/ena/data/view/DQ654412
EMBL	DQ654413	http://www.ebi.ac.uk/ena/data/view/DQ654413
EMBL	DQ654414	http://www.ebi.ac.uk/ena/data/view/DQ654414
EMBL	DQ654415	http://www.ebi.ac.uk/ena/data/view/DQ654415
EMBL	DQ654416	http://www.ebi.ac.uk/ena/data/view/DQ654416
EMBL	DQ654417	http://www.ebi.ac.uk/ena/data/view/DQ654417
EMBL	DQ654418	http://www.ebi.ac.uk/ena/data/view/DQ654418
EMBL	DQ654419	http://www.ebi.ac.uk/ena/data/view/DQ654419
EMBL	DQ654420	http://www.ebi.ac.uk/ena/data/view/DQ654420
EMBL	DQ654421	http://www.ebi.ac.uk/ena/data/view/DQ654421
EMBL	DQ654422	http://www.ebi.ac.uk/ena/data/view/DQ654422
EMBL	DQ654423	http://www.ebi.ac.uk/ena/data/view/DQ654423
EMBL	DQ654424	http://www.ebi.ac.uk/ena/data/view/DQ654424
EMBL	DQ654425	http://www.ebi.ac.uk/ena/data/view/DQ654425
EMBL	DQ654426	http://www.ebi.ac.uk/ena/data/view/DQ654426
EMBL	DQ654427	http://www.ebi.ac.uk/ena/data/view/DQ654427
EMBL	DQ654428	http://www.ebi.ac.uk/ena/data/view/DQ654428
EMBL	DQ654429	http://www.ebi.ac.uk/ena/data/view/DQ654429
EMBL	DQ654430	http://www.ebi.ac.uk/ena/data/view/DQ654430
EMBL	DQ654431	http://www.ebi.ac.uk/ena/data/view/DQ654431
EMBL	DQ654432	http://www.ebi.ac.uk/ena/data/view/DQ654432
EMBL	DQ654433	http://www.ebi.ac.uk/ena/data/view/DQ654433
EMBL	DQ654434	http://www.ebi.ac.uk/ena/data/view/DQ654434
EMBL	DQ654435	http://www.ebi.ac.uk/ena/data/view/DQ654435
EMBL	DQ654436	http://www.ebi.ac.uk/ena/data/view/DQ654436
EMBL	DQ654437	http://www.ebi.ac.uk/ena/data/view/DQ654437
EMBL	DQ654438	http://www.ebi.ac.uk/ena/data/view/DQ654438
EMBL	DQ654439	http://www.ebi.ac.uk/ena/data/view/DQ654439
EMBL	DQ654440	http://www.ebi.ac.uk/ena/data/view/DQ654440
EMBL	DQ654441	http://www.ebi.ac.uk/ena/data/view/DQ654441
EMBL	DQ654442	http://www.ebi.ac.uk/ena/data/view/DQ654442
EMBL	DQ654443	http://www.ebi.ac.uk/ena/data/view/DQ654443
EMBL	J01415	http://www.ebi.ac.uk/ena/data/view/J01415
EMBL	V00662	http://www.ebi.ac.uk/ena/data/view/V00662
Ensembl	ENST00000362079	http://www.ensembl.org/id/ENST00000362079
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0045277	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045277
GO_function	GO:0004129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004129
GO_process	GO:0006123	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006123
GO_process	GO:0008535	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008535
GO_process	GO:0019646	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019646
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
Gene3D	1.20.120.80	http://www.cathdb.info/version/latest/superfamily/1.20.120.80
GeneCards	MT-CO3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=MT-CO3
GeneID	4514	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4514
GeneTree	ENSGT00390000013064	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000013064
H-InvDB	HIX0060139	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0060139
HGNC	HGNC:7422	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:7422
HOGENOM	HOG000264954	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264954&db=HOGENOM6
HOVERGEN	HBG016686	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG016686&db=HOVERGEN
HPA	HPA042788	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042788
InParanoid	P00414	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00414
IntAct	P00414	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00414*
InterPro	IPR000298	http://www.ebi.ac.uk/interpro/entry/IPR000298
InterPro	IPR013833	http://www.ebi.ac.uk/interpro/entry/IPR013833
InterPro	IPR024791	http://www.ebi.ac.uk/interpro/entry/IPR024791
InterPro	IPR033945	http://www.ebi.ac.uk/interpro/entry/IPR033945
Jabion	4514	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=4514
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Disease	H00068	http://www.genome.jp/dbget-bin/www_bget?H00068
KEGG_Disease	H01355	http://www.genome.jp/dbget-bin/www_bget?H01355
KEGG_Disease	H01368	http://www.genome.jp/dbget-bin/www_bget?H01368
KEGG_Gene	hsa:4514	http://www.genome.jp/dbget-bin/www_bget?hsa:4514
KEGG_Orthology	KO:K02262	http://www.genome.jp/dbget-bin/www_bget?KO:K02262
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	220110	http://www.ncbi.nlm.nih.gov/omim/220110
MIM	516050	http://www.ncbi.nlm.nih.gov/omim/516050
MIM	535000	http://www.ncbi.nlm.nih.gov/omim/535000
MIM	540000	http://www.ncbi.nlm.nih.gov/omim/540000
MIM	550500	http://www.ncbi.nlm.nih.gov/omim/550500
OMA	PWPLTGA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PWPLTGA
Orphanet	104	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=104
Orphanet	254905	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=254905
Orphanet	255210	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=255210
Orphanet	550	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=550
Orphanet	99845	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=99845
OrthoDB	EOG091G0GH8	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0GH8
PANTHER	PTHR11403	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11403
PROSITE	PS50253	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50253
PSORT	swissprot:COX3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:COX3_HUMAN
PSORT-B	swissprot:COX3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:COX3_HUMAN
PSORT2	swissprot:COX3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:COX3_HUMAN
Pfam	PF00510	http://pfam.xfam.org/family/PF00510
Phobius	swissprot:COX3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:COX3_HUMAN
PhylomeDB	P00414	http://phylomedb.org/?seqid=P00414
ProteinModelPortal	P00414	http://www.proteinmodelportal.org/query/uniprot/P00414
PubMed	16776823	http://www.ncbi.nlm.nih.gov/pubmed/16776823
PubMed	1757091	http://www.ncbi.nlm.nih.gov/pubmed/1757091
PubMed	18587274	http://www.ncbi.nlm.nih.gov/pubmed/18587274
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	7219534	http://www.ncbi.nlm.nih.gov/pubmed/7219534
PubMed	7496173	http://www.ncbi.nlm.nih.gov/pubmed/7496173
PubMed	8240356	http://www.ncbi.nlm.nih.gov/pubmed/8240356
PubMed	8630495	http://www.ncbi.nlm.nih.gov/pubmed/8630495
PubMed	9461455	http://www.ncbi.nlm.nih.gov/pubmed/9461455
Reactome	R-HSA-5628897	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5628897
Reactome	R-HSA-611105	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-611105
RefSeq	YP_003024032	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_003024032
SMR	P00414	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00414
STRING	9606.ENSP00000354982	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000354982&targetmode=cogs
STRING	COG1845	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1845&targetmode=cogs
SUPFAM	SSF81452	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81452
TCDB	3.D.4.11	http://www.tcdb.org/search/result.php?tc=3.D.4.11
UniProtKB	COX3_HUMAN	http://www.uniprot.org/uniprot/COX3_HUMAN
UniProtKB-AC	P00414	http://www.uniprot.org/uniprot/P00414
charge	swissprot:COX3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:COX3_HUMAN
eggNOG	COG1845	http://eggnogapi.embl.de/nog_data/html/tree/COG1845
eggNOG	KOG4664	http://eggnogapi.embl.de/nog_data/html/tree/KOG4664
epestfind	swissprot:COX3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:COX3_HUMAN
garnier	swissprot:COX3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:COX3_HUMAN
helixturnhelix	swissprot:COX3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:COX3_HUMAN
hmoment	swissprot:COX3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:COX3_HUMAN
iep	swissprot:COX3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:COX3_HUMAN
inforesidue	swissprot:COX3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:COX3_HUMAN
neXtProt	NX_P00414	http://www.nextprot.org/db/entry/NX_P00414
octanol	swissprot:COX3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:COX3_HUMAN
pepcoil	swissprot:COX3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:COX3_HUMAN
pepdigest	swissprot:COX3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:COX3_HUMAN
pepinfo	swissprot:COX3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:COX3_HUMAN
pepnet	swissprot:COX3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:COX3_HUMAN
pepstats	swissprot:COX3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:COX3_HUMAN
pepwheel	swissprot:COX3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:COX3_HUMAN
pepwindow	swissprot:COX3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:COX3_HUMAN
sigcleave	swissprot:COX3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:COX3_HUMAN
## Database	ID	URL or Descriptions
# AltName	S38A4_HUMAN	Amino acid transporter A3
# AltName	S38A4_HUMAN	Na(+)-coupled neutral amino acid transporter 4
# AltName	S38A4_HUMAN	Solute carrier family 38 member 4
# AltName	S38A4_HUMAN	System A amino acid transporter 3
# AltName	S38A4_HUMAN	System N amino acid transporter 3
# BIOPHYSICOCHEMICAL PROPERTIES	pH dependence: Optimum pH is 7.5-8.5. {ECO	0000269|PubMed:11342143}; 
# Ensembl	ENST00000266579	ENSP00000266579; ENSG00000139209
# Ensembl	ENST00000447411	ENSP00000389843; ENSG00000139209
# ExpressionAtlas	Q969I6	baseline and differential
# FUNCTION	S38A4_HUMAN	Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium- independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5. {ECO 0000269|PubMed 11342143, ECO 0000269|PubMed 11414754}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_process	GO:0003333	amino acid transmembrane transport; IBA:GO_Central.
# GO_process	GO:0006814	sodium ion transport; IEA:UniProtKB-KW.
# GO_process	GO:0006865	amino acid transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q969I6	HS
# HGNC	HGNC:14679	SLC38A4
# InterPro	IPR013057	AA_transpt_TM
# KEGG_Brite	ko02001	Solute carrier family
# MIM	608065	gene
# Organism	S38A4_HUMAN	Homo sapiens (Human)
# PTM	S38A4_HUMAN	The disulfide bond plays an important role in substrate transport, but has no effect on trafficking to the cell surface. {ECO 0000250}. 
# Pfam	PF01490	Aa_trans; 2
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-352230	Amino acid transport across the plasma membrane
# RecName	S38A4_HUMAN	Sodium-coupled neutral amino acid transporter 4
# RefSeq	NP_001137296	NM_001143824.1
# RefSeq	NP_060488	NM_018018.4
# RefSeq	XP_005269054	XM_005268997.2
# SIMILARITY	Belongs to the amino acid/polyamine transporter 2 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S38A4_HUMAN	Cell membrane {ECO 0000269|PubMed 11414754, ECO 0000269|PubMed 16148032}; Multi-pass membrane protein {ECO 0000269|PubMed 11414754, ECO 0000269|PubMed 16148032}. 
# TCDB	2.A.18.6.17	the amino acid/auxin permease (aaap) family
# TISSUE SPECIFICITY	S38A4_HUMAN	Detected in embryonic and adult liver, and at lower levels in adult muscle, kidney and pancreas. Detected in placenta syncytiotrophoblasts throughout gestation. Detected in fetal blood vessels. {ECO 0000269|PubMed 11342143, ECO 0000269|PubMed 11414754, ECO 0000269|PubMed 16148032}. 
# UCSC	uc001rpi	human
# eggNOG	COG0814	LUCA
# eggNOG	KOG1305	Eukaryota
BLAST	swissprot:S38A4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S38A4_HUMAN
BioCyc	ZFISH:ENSG00000139209-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000139209-MONOMER
COXPRESdb	55089	http://coxpresdb.jp/data/gene/55089.shtml
CleanEx	HS_SLC38A4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC38A4
DOI	10.1006/geno.2001.6567	http://dx.doi.org/10.1006/geno.2001.6567
DOI	10.1007/s00424-003-1117-9	http://dx.doi.org/10.1007/s00424-003-1117-9
DOI	10.1016/S0005-2736(00)00390-4	http://dx.doi.org/10.1016/S0005-2736(00)00390-4
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M111.220277	http://dx.doi.org/10.1074/jbc.M111.220277
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1152/ajpcell.00258.2005	http://dx.doi.org/10.1152/ajpcell.00258.2005
EMBL	AB055003	http://www.ebi.ac.uk/ena/data/view/AB055003
EMBL	AF193836	http://www.ebi.ac.uk/ena/data/view/AF193836
EMBL	AF305814	http://www.ebi.ac.uk/ena/data/view/AF305814
EMBL	AK291168	http://www.ebi.ac.uk/ena/data/view/AK291168
EMBL	BC069819	http://www.ebi.ac.uk/ena/data/view/BC069819
EMBL	BC101827	http://www.ebi.ac.uk/ena/data/view/BC101827
EMBL	BC104913	http://www.ebi.ac.uk/ena/data/view/BC104913
EMBL	CH471111	http://www.ebi.ac.uk/ena/data/view/CH471111
Ensembl	ENST00000266579	http://www.ensembl.org/id/ENST00000266579
Ensembl	ENST00000447411	http://www.ensembl.org/id/ENST00000447411
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_process	GO:0003333	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003333
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC38A4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC38A4
GeneID	55089	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55089
GeneTree	ENSGT00760000119147	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119147
HGNC	HGNC:14679	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14679
HOGENOM	HOG000013088	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000013088&db=HOGENOM6
HOVERGEN	HBG059571	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG059571&db=HOVERGEN
InParanoid	Q969I6	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q969I6
InterPro	IPR013057	http://www.ebi.ac.uk/interpro/entry/IPR013057
Jabion	55089	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55089
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:55089	http://www.genome.jp/dbget-bin/www_bget?hsa:55089
KEGG_Orthology	KO:K14991	http://www.genome.jp/dbget-bin/www_bget?KO:K14991
MIM	608065	http://www.ncbi.nlm.nih.gov/omim/608065
OMA	NTLPMHV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NTLPMHV
OrthoDB	EOG091G0GP8	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0GP8
PSORT	swissprot:S38A4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S38A4_HUMAN
PSORT-B	swissprot:S38A4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S38A4_HUMAN
PSORT2	swissprot:S38A4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S38A4_HUMAN
Pfam	PF01490	http://pfam.xfam.org/family/PF01490
PharmGKB	PA37908	http://www.pharmgkb.org/do/serve?objId=PA37908&objCls=Gene
Phobius	swissprot:S38A4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S38A4_HUMAN
PhylomeDB	Q969I6	http://phylomedb.org/?seqid=Q969I6
ProteinModelPortal	Q969I6	http://www.proteinmodelportal.org/query/uniprot/Q969I6
PubMed	11342143	http://www.ncbi.nlm.nih.gov/pubmed/11342143
PubMed	11414754	http://www.ncbi.nlm.nih.gov/pubmed/11414754
PubMed	12845534	http://www.ncbi.nlm.nih.gov/pubmed/12845534
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16148032	http://www.ncbi.nlm.nih.gov/pubmed/16148032
PubMed	21917917	http://www.ncbi.nlm.nih.gov/pubmed/21917917
Reactome	R-HSA-352230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-352230
RefSeq	NP_001137296	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001137296
RefSeq	NP_060488	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060488
RefSeq	XP_005269054	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005269054
STRING	9606.ENSP00000266579	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000266579&targetmode=cogs
TCDB	2.A.18.6.17	http://www.tcdb.org/search/result.php?tc=2.A.18.6.17
UCSC	uc001rpi	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001rpi&org=rat
UniGene	Hs.446077	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.446077
UniProtKB	S38A4_HUMAN	http://www.uniprot.org/uniprot/S38A4_HUMAN
UniProtKB-AC	Q969I6	http://www.uniprot.org/uniprot/Q969I6
charge	swissprot:S38A4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S38A4_HUMAN
eggNOG	COG0814	http://eggnogapi.embl.de/nog_data/html/tree/COG0814
eggNOG	KOG1305	http://eggnogapi.embl.de/nog_data/html/tree/KOG1305
epestfind	swissprot:S38A4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S38A4_HUMAN
garnier	swissprot:S38A4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S38A4_HUMAN
helixturnhelix	swissprot:S38A4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S38A4_HUMAN
hmoment	swissprot:S38A4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S38A4_HUMAN
iep	swissprot:S38A4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S38A4_HUMAN
inforesidue	swissprot:S38A4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S38A4_HUMAN
neXtProt	NX_Q969I6	http://www.nextprot.org/db/entry/NX_Q969I6
octanol	swissprot:S38A4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S38A4_HUMAN
pepcoil	swissprot:S38A4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S38A4_HUMAN
pepdigest	swissprot:S38A4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S38A4_HUMAN
pepinfo	swissprot:S38A4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S38A4_HUMAN
pepnet	swissprot:S38A4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S38A4_HUMAN
pepstats	swissprot:S38A4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S38A4_HUMAN
pepwheel	swissprot:S38A4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S38A4_HUMAN
pepwindow	swissprot:S38A4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S38A4_HUMAN
sigcleave	swissprot:S38A4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S38A4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SPX3_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8NCC5-1; Sequence=Displayed; Name=2; IsoId=Q8NCC5-2; Sequence=VSP_029114; Note=No experimental confirmation available.; Name=3; IsoId=Q8NCC5-3; Sequence=VSP_029113, VSP_029115; Note=No experimental confirmation available.; 
# AltName	SPX3_HUMAN	Solute carrier family 37 member 3
# BioGrid	123982	22
# CCDS	CCDS5858	-. [Q8NCC5-3]
# CCDS	CCDS5859	-. [Q8NCC5-1]
# CCDS	CCDS75669	-. [Q8NCC5-2]
# CDD	cd06174	MFS
# ChiTaRS	SLC37A3	human
# Ensembl	ENST00000326232	ENSP00000321498; ENSG00000157800. [Q8NCC5-1]
# Ensembl	ENST00000340308	ENSP00000343358; ENSG00000157800. [Q8NCC5-3]
# Ensembl	ENST00000447932	ENSP00000397481; ENSG00000157800. [Q8NCC5-2]
# ExpressionAtlas	Q8NCC5	baseline and differential
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0030176	integral component of endoplasmic reticulum membrane; IDA:UniProtKB.
# GO_function	GO:0022857	transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0006820	anion transport; IBA:GO_Central.
# GO_process	GO:0008643	carbohydrate transport; IEA:UniProtKB-KW.
# GO_process	GO:0055085	transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q8NCC5	HS
# HGNC	HGNC:20651	SLC37A3
# IntAct	Q8NCC5	2
# InterPro	IPR000849	Sugar_P_transporter
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# Organism	SPX3_HUMAN	Homo sapiens (Human)
# PIRSF	PIRSF002808	Hexose_phosphate_transp
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 7
# RecName	SPX3_HUMAN	Sugar phosphate exchanger 3
# RefSeq	NP_001274427	NM_001287498.1. [Q8NCC5-2]
# RefSeq	NP_115671	NM_032295.3. [Q8NCC5-3]
# RefSeq	NP_996996	NM_207113.2. [Q8NCC5-1]
# RefSeq	XP_016868201	XM_017012712.1. [Q8NCC5-1]
# RefSeq	XP_016868202	XM_017012713.1. [Q8NCC5-3]
# SIMILARITY	Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	SPX3_HUMAN	Endoplasmic reticulum membrane {ECO 0000269|PubMed 21949678}; Multi-pass membrane protein {ECO 0000255}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.4	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	Expressed in liver, kidney, intestine and pancreas. {ECO:0000269|PubMed	21949678}. 
# UCSC	uc003vvo	human. [Q8NCC5-1]
# eggNOG	COG2271	LUCA
# eggNOG	ENOG410IP3Z	Eukaryota
BLAST	swissprot:SPX3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SPX3_HUMAN
COXPRESdb	84255	http://coxpresdb.jp/data/gene/84255.shtml
CleanEx	HS_SLC37A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC37A3
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1101/gr.GR1547R	http://dx.doi.org/10.1101/gr.GR1547R
DOI	10.1126/science.1083423	http://dx.doi.org/10.1126/science.1083423
DOI	10.1371/journal.pone.0023157	http://dx.doi.org/10.1371/journal.pone.0023157
EMBL	AC093087	http://www.ebi.ac.uk/ena/data/view/AC093087
EMBL	AK074823	http://www.ebi.ac.uk/ena/data/view/AK074823
EMBL	AL136583	http://www.ebi.ac.uk/ena/data/view/AL136583
EMBL	BC028380	http://www.ebi.ac.uk/ena/data/view/BC028380
EMBL	BC046567	http://www.ebi.ac.uk/ena/data/view/BC046567
EMBL	CH236950	http://www.ebi.ac.uk/ena/data/view/CH236950
EMBL	CH236950	http://www.ebi.ac.uk/ena/data/view/CH236950
EMBL	CH471070	http://www.ebi.ac.uk/ena/data/view/CH471070
EMBL	CH471070	http://www.ebi.ac.uk/ena/data/view/CH471070
EMBL	CH471070	http://www.ebi.ac.uk/ena/data/view/CH471070
Ensembl	ENST00000326232	http://www.ensembl.org/id/ENST00000326232
Ensembl	ENST00000340308	http://www.ensembl.org/id/ENST00000340308
Ensembl	ENST00000447932	http://www.ensembl.org/id/ENST00000447932
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0030176	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030176
GO_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GO_process	GO:0006820	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006820
GO_process	GO:0008643	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008643
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC37A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC37A3
GeneID	84255	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84255
GeneTree	ENSGT00530000062949	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062949
HGNC	HGNC:20651	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20651
HOGENOM	HOG000230522	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230522&db=HOGENOM6
HOVERGEN	HBG005851	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG005851&db=HOVERGEN
HPA	HPA014713	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014713
HPA	HPA061841	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA061841
InParanoid	Q8NCC5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8NCC5
IntAct	Q8NCC5	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8NCC5*
InterPro	IPR000849	http://www.ebi.ac.uk/interpro/entry/IPR000849
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	84255	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=84255
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:84255	http://www.genome.jp/dbget-bin/www_bget?hsa:84255
KEGG_Orthology	KO:K03447	http://www.genome.jp/dbget-bin/www_bget?KO:K03447
MINT	MINT-4786742	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4786742
OMA	KYGYEYA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KYGYEYA
OrthoDB	EOG091G066D	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G066D
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:SPX3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SPX3_HUMAN
PSORT-B	swissprot:SPX3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SPX3_HUMAN
PSORT2	swissprot:SPX3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SPX3_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA134895240	http://www.pharmgkb.org/do/serve?objId=PA134895240&objCls=Gene
Phobius	swissprot:SPX3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SPX3_HUMAN
PhylomeDB	Q8NCC5	http://phylomedb.org/?seqid=Q8NCC5
ProteinModelPortal	Q8NCC5	http://www.proteinmodelportal.org/query/uniprot/Q8NCC5
PubMed	11230166	http://www.ncbi.nlm.nih.gov/pubmed/11230166
PubMed	12690205	http://www.ncbi.nlm.nih.gov/pubmed/12690205
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21949678	http://www.ncbi.nlm.nih.gov/pubmed/21949678
RefSeq	NP_001274427	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001274427
RefSeq	NP_115671	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_115671
RefSeq	NP_996996	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_996996
RefSeq	XP_016868201	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016868201
RefSeq	XP_016868202	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016868202
STRING	9606.ENSP00000321498	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000321498&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.4	http://www.tcdb.org/search/result.php?tc=2.A.1.4
UCSC	uc003vvo	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003vvo&org=rat
UniGene	Hs.446021	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.446021
UniGene	Hs.738791	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.738791
UniProtKB	SPX3_HUMAN	http://www.uniprot.org/uniprot/SPX3_HUMAN
UniProtKB-AC	Q8NCC5	http://www.uniprot.org/uniprot/Q8NCC5
charge	swissprot:SPX3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SPX3_HUMAN
eggNOG	COG2271	http://eggnogapi.embl.de/nog_data/html/tree/COG2271
eggNOG	ENOG410IP3Z	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IP3Z
epestfind	swissprot:SPX3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SPX3_HUMAN
garnier	swissprot:SPX3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SPX3_HUMAN
helixturnhelix	swissprot:SPX3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SPX3_HUMAN
hmoment	swissprot:SPX3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SPX3_HUMAN
iep	swissprot:SPX3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SPX3_HUMAN
inforesidue	swissprot:SPX3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SPX3_HUMAN
neXtProt	NX_Q8NCC5	http://www.nextprot.org/db/entry/NX_Q8NCC5
octanol	swissprot:SPX3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SPX3_HUMAN
pepcoil	swissprot:SPX3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SPX3_HUMAN
pepdigest	swissprot:SPX3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SPX3_HUMAN
pepinfo	swissprot:SPX3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SPX3_HUMAN
pepnet	swissprot:SPX3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SPX3_HUMAN
pepstats	swissprot:SPX3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SPX3_HUMAN
pepwheel	swissprot:SPX3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SPX3_HUMAN
pepwindow	swissprot:SPX3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SPX3_HUMAN
sigcleave	swissprot:SPX3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SPX3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SCMC1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6NUK1-1; Sequence=Displayed; Name=2; IsoId=Q6NUK1-2; Sequence=VSP_031066; 
# AltName	SCMC1_HUMAN	Mitochondrial ATP-Mg/Pi carrier protein 1
# AltName	SCMC1_HUMAN	Mitochondrial Ca(2+)-dependent solute carrier protein 1
# AltName	SCMC1_HUMAN	Small calcium-binding mitochondrial carrier protein 1
# AltName	SCMC1_HUMAN	Solute carrier family 25 member 24
# BIOPHYSICOCHEMICAL PROPERTIES	SCMC1_HUMAN	Kinetic parameters  KM=0.97 mM for AMP {ECO 0000269|PubMed 15123600}; KM=0.3 mM for ADP {ECO 0000269|PubMed 15123600}; KM=0.33 mM for ATP {ECO 0000269|PubMed 15123600}; KM=0.2 mM for ATP-Mg {ECO 0000269|PubMed 15123600}; KM=1.64 mM for Pi {ECO 0000269|PubMed 15123600}; Vmax=337 umol/min/g enzyme with AMP as substrate {ECO 0000269|PubMed 15123600}; Vmax=345 umol/min/g enzyme with ADP as substrate {ECO 0000269|PubMed 15123600}; Vmax=320 umol/min/g enzyme with ATP as substrate {ECO 0000269|PubMed 15123600}; Vmax=365 umol/min/g enzyme with ATP-Mg as substrate {ECO 0000269|PubMed 15123600}; Vmax=380 umol/min/g enzyme with Pi as substrate {ECO 0000269|PubMed 15123600}; 
# BioGrid	118993	29
# CCDS	CCDS41361	-. [Q6NUK1-1]
# CCDS	CCDS786	-. [Q6NUK1-2]
# CDD	cd00051	EFh; 2
# ChiTaRS	SLC25A24	human
# DOMAIN	SCMC1_HUMAN	The N-terminal domain can bind calcium and regulates the ATP carrier activity of the transmembrane domain. The apo form of the N-terminal domain is intrinsically disordered and binds to the transmembrane domain, leading to inhibition of the ATP carrier activity. Calcium binding leads to a major conformation change and abolishes the interaction with the transmembrane domain and the inhibition of the ATP carrier activity (PubMed 24332718). {ECO 0000269|PubMed 24332718}. 
# Ensembl	ENST00000370041	ENSP00000359058; ENSG00000085491. [Q6NUK1-2]
# Ensembl	ENST00000565488	ENSP00000457733; ENSG00000085491. [Q6NUK1-1]
# ExpressionAtlas	Q6NUK1	baseline and differential
# FUNCTION	SCMC1_HUMAN	Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress- induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix. {ECO 0000269|PubMed 15123600, ECO 0000269|PubMed 22015608}. 
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016021	integral component of membrane; IDA:UniProtKB.
# GO_function	GO:0005347	ATP transmembrane transporter activity; IMP:UniProtKB.
# GO_function	GO:0005509	calcium ion binding; IDA:UniProtKB.
# GO_process	GO:0006839	mitochondrial transport; IMP:UniProtKB.
# GO_process	GO:0010941	regulation of cell death; IMP:UniProtKB.
# GO_process	GO:0015867	ATP transport; IMP:UniProtKB.
# GO_process	GO:0034599	cellular response to oxidative stress; IMP:UniProtKB.
# GO_process	GO:0071277	cellular response to calcium ion; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.10.238.10	-; 1.
# Gene3D	1.50.40.10	-; 1.
# Genevisible	Q6NUK1	HS
# HGNC	HGNC:20662	SLC25A24
# IntAct	Q6NUK1	5
# InterPro	IPR002048	EF_hand_dom
# InterPro	IPR002067	Mit_carrier
# InterPro	IPR002167	Graves_DC
# InterPro	IPR011992	EF-hand-dom_pair
# InterPro	IPR018108	Mitochondrial_sb/sol_carrier
# InterPro	IPR018247	EF_Hand_1_Ca_BS
# InterPro	IPR023395	Mt_carrier_dom
# KEGG_Brite	ko02001	Solute carrier family
# MIM	608744	gene
# Organism	SCMC1_HUMAN	Homo sapiens (Human)
# PDB	4N5X	X-ray; 2.10 A; A=1-193
# PDB	4ZCU	X-ray; 2.10 A; A/B/C=14-174
# PDB	4ZCV	X-ray; 2.80 A; A/B/C/D=14-174
# PRINTS	PR00926	MITOCARRIER
# PRINTS	PR00928	GRAVESDC
# PROSITE	PS00018	EF_HAND_1; 3
# PROSITE	PS50222	EF_HAND_2; 4
# PROSITE	PS50920	SOLCAR; 3
# Pfam	PF00153	Mito_carr; 3
# Pfam	PF13499	EF-hand_7; 2
# Proteomes	UP000005640	Chromosome 1
# RecName	SCMC1_HUMAN	Calcium-binding mitochondrial carrier protein SCaMC-1
# RefSeq	NP_037518	NM_013386.4. [Q6NUK1-1]
# RefSeq	NP_998816	NM_213651.2. [Q6NUK1-2]
# SEQUENCE CAUTION	Sequence=AAF28888.1; Type=Frameshift; Positions=418, 464; Evidence={ECO:0000305}; Sequence=CAI13622.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305}; Sequence=CAI14512.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
# SIMILARITY	Belongs to the mitochondrial carrier (TC 2.A.29) family. {ECO	0000305}. 
# SIMILARITY	Contains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule	PRU00282}. 
# SIMILARITY	Contains 4 EF-hand domains. {ECO:0000255|PROSITE- ProRule	PRU00448}. 
# SMART	SM00054	EFh; 3
# SUBCELLULAR LOCATION	SCMC1_HUMAN	Mitochondrion inner membrane {ECO 0000269|PubMed 15054102, ECO 0000269|PubMed 15123600, ECO 0000269|PubMed 22015608}; Multi-pass membrane protein {ECO 0000269|PubMed 15054102, ECO 0000269|PubMed 15123600, ECO 0000269|PubMed 22015608}. 
# SUPFAM	SSF103506	SSF103506
# SUPFAM	SSF47473	SSF47473
# TCDB	2.A.29.23	the mitochondrial carrier (mc) family
# TISSUE SPECIFICITY	SCMC1_HUMAN	Present in various cell lines (at protein level). Expressed in all tissues tested. Highly expressed in testis, expressed at intermediate level in small intestine and pancreas, and weakly expressed in kidney, spleen, liver, skeletal muscle and heart. {ECO 0000269|PubMed 15054102, ECO 0000269|PubMed 15123600}. 
# TopDownProteomics	Q6NUK1-1	-. [Q6NUK1-1]
# TopDownProteomics	Q6NUK1-2	-. [Q6NUK1-2]
# UCSC	uc001dvm	human. [Q6NUK1-1]
# eggNOG	ENOG410XQ4P	LUCA
# eggNOG	KOG0036	Eukaryota
BLAST	swissprot:SCMC1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SCMC1_HUMAN
COXPRESdb	29957	http://coxpresdb.jp/data/gene/29957.shtml
CleanEx	HS_SLC25A24	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC25A24
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.str.2013.10.018	http://dx.doi.org/10.1016/j.str.2013.10.018
DOI	10.1038/cdd.2011.139	http://dx.doi.org/10.1038/cdd.2011.139
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M400445200	http://dx.doi.org/10.1074/jbc.M400445200
DOI	10.1074/jbc.M401417200	http://dx.doi.org/10.1074/jbc.M401417200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF123303	http://www.ebi.ac.uk/ena/data/view/AF123303
EMBL	AJ619961	http://www.ebi.ac.uk/ena/data/view/AJ619961
EMBL	AJ619987	http://www.ebi.ac.uk/ena/data/view/AJ619987
EMBL	AK292567	http://www.ebi.ac.uk/ena/data/view/AK292567
EMBL	AK316304	http://www.ebi.ac.uk/ena/data/view/AK316304
EMBL	AL359258	http://www.ebi.ac.uk/ena/data/view/AL359258
EMBL	AL359258	http://www.ebi.ac.uk/ena/data/view/AL359258
EMBL	AL359258	http://www.ebi.ac.uk/ena/data/view/AL359258
EMBL	AL359258	http://www.ebi.ac.uk/ena/data/view/AL359258
EMBL	AL390036	http://www.ebi.ac.uk/ena/data/view/AL390036
EMBL	AL390036	http://www.ebi.ac.uk/ena/data/view/AL390036
EMBL	AL390036	http://www.ebi.ac.uk/ena/data/view/AL390036
EMBL	AL390036	http://www.ebi.ac.uk/ena/data/view/AL390036
EMBL	BC014519	http://www.ebi.ac.uk/ena/data/view/BC014519
EMBL	BC068561	http://www.ebi.ac.uk/ena/data/view/BC068561
EMBL	CH471156	http://www.ebi.ac.uk/ena/data/view/CH471156
EMBL	CH471156	http://www.ebi.ac.uk/ena/data/view/CH471156
Ensembl	ENST00000370041	http://www.ensembl.org/id/ENST00000370041
Ensembl	ENST00000565488	http://www.ensembl.org/id/ENST00000565488
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005347	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005347
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_process	GO:0006839	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006839
GO_process	GO:0010941	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010941
GO_process	GO:0015867	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015867
GO_process	GO:0034599	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034599
GO_process	GO:0071277	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071277
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.10.238.10	http://www.cathdb.info/version/latest/superfamily/1.10.238.10
Gene3D	1.50.40.10	http://www.cathdb.info/version/latest/superfamily/1.50.40.10
GeneCards	SLC25A24	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC25A24
GeneID	29957	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29957
GeneTree	ENSGT00760000119245	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119245
H-InvDB	HIX0000832	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0000832
H-InvDB	HIX0023826	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0023826
HGNC	HGNC:20662	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20662
HOVERGEN	HBG108464	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108464&db=HOVERGEN
HPA	HPA028519	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA028519
HPA	HPA063636	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA063636
InParanoid	Q6NUK1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6NUK1
IntAct	Q6NUK1	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q6NUK1*
InterPro	IPR002048	http://www.ebi.ac.uk/interpro/entry/IPR002048
InterPro	IPR002067	http://www.ebi.ac.uk/interpro/entry/IPR002067
InterPro	IPR002167	http://www.ebi.ac.uk/interpro/entry/IPR002167
InterPro	IPR011992	http://www.ebi.ac.uk/interpro/entry/IPR011992
InterPro	IPR018108	http://www.ebi.ac.uk/interpro/entry/IPR018108
InterPro	IPR018247	http://www.ebi.ac.uk/interpro/entry/IPR018247
InterPro	IPR023395	http://www.ebi.ac.uk/interpro/entry/IPR023395
Jabion	29957	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=29957
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:29957	http://www.genome.jp/dbget-bin/www_bget?hsa:29957
KEGG_Orthology	KO:K14684	http://www.genome.jp/dbget-bin/www_bget?KO:K14684
MIM	608744	http://www.ncbi.nlm.nih.gov/omim/608744
MINT	MINT-4905805	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4905805
OMA	TTWLEHY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TTWLEHY
OrthoDB	EOG091G0C8S	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0C8S
PDB	4N5X	http://www.ebi.ac.uk/pdbe-srv/view/entry/4N5X
PDB	4ZCU	http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZCU
PDB	4ZCV	http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZCV
PDBsum	4N5X	http://www.ebi.ac.uk/pdbsum/4N5X
PDBsum	4ZCU	http://www.ebi.ac.uk/pdbsum/4ZCU
PDBsum	4ZCV	http://www.ebi.ac.uk/pdbsum/4ZCV
PRINTS	PR00926	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00926
PRINTS	PR00928	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00928
PROSITE	PS00018	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00018
PROSITE	PS50222	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50222
PROSITE	PS50920	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50920
PSORT	swissprot:SCMC1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SCMC1_HUMAN
PSORT-B	swissprot:SCMC1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SCMC1_HUMAN
PSORT2	swissprot:SCMC1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SCMC1_HUMAN
Pfam	PF00153	http://pfam.xfam.org/family/PF00153
Pfam	PF13499	http://pfam.xfam.org/family/PF13499
PharmGKB	PA134978257	http://www.pharmgkb.org/do/serve?objId=PA134978257&objCls=Gene
Phobius	swissprot:SCMC1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SCMC1_HUMAN
PhylomeDB	Q6NUK1	http://phylomedb.org/?seqid=Q6NUK1
ProteinModelPortal	Q6NUK1	http://www.proteinmodelportal.org/query/uniprot/Q6NUK1
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15054102	http://www.ncbi.nlm.nih.gov/pubmed/15054102
PubMed	15123600	http://www.ncbi.nlm.nih.gov/pubmed/15123600
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22015608	http://www.ncbi.nlm.nih.gov/pubmed/22015608
PubMed	24332718	http://www.ncbi.nlm.nih.gov/pubmed/24332718
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
RefSeq	NP_037518	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_037518
RefSeq	NP_998816	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_998816
SMART	SM00054	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00054
SMR	Q6NUK1	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q6NUK1
STRING	9606.ENSP00000457733	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000457733&targetmode=cogs
SUPFAM	SSF103506	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103506
SUPFAM	SSF47473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47473
TCDB	2.A.29.23	http://www.tcdb.org/search/result.php?tc=2.A.29.23
UCSC	uc001dvm	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001dvm&org=rat
UniGene	Hs.656870	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.656870
UniProtKB	SCMC1_HUMAN	http://www.uniprot.org/uniprot/SCMC1_HUMAN
UniProtKB-AC	Q6NUK1	http://www.uniprot.org/uniprot/Q6NUK1
charge	swissprot:SCMC1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SCMC1_HUMAN
eggNOG	ENOG410XQ4P	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ4P
eggNOG	KOG0036	http://eggnogapi.embl.de/nog_data/html/tree/KOG0036
epestfind	swissprot:SCMC1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SCMC1_HUMAN
garnier	swissprot:SCMC1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SCMC1_HUMAN
helixturnhelix	swissprot:SCMC1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SCMC1_HUMAN
hmoment	swissprot:SCMC1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SCMC1_HUMAN
iep	swissprot:SCMC1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SCMC1_HUMAN
inforesidue	swissprot:SCMC1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SCMC1_HUMAN
neXtProt	NX_Q6NUK1	http://www.nextprot.org/db/entry/NX_Q6NUK1
octanol	swissprot:SCMC1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SCMC1_HUMAN
pepcoil	swissprot:SCMC1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SCMC1_HUMAN
pepdigest	swissprot:SCMC1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SCMC1_HUMAN
pepinfo	swissprot:SCMC1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SCMC1_HUMAN
pepnet	swissprot:SCMC1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SCMC1_HUMAN
pepstats	swissprot:SCMC1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SCMC1_HUMAN
pepwheel	swissprot:SCMC1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SCMC1_HUMAN
pepwindow	swissprot:SCMC1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SCMC1_HUMAN
sigcleave	swissprot:SCMC1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SCMC1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SCN1A_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P35498-1; Sequence=Displayed; Name=2; IsoId=P35498-2; Sequence=VSP_001031; Name=3; IsoId=P35498-3; Sequence=VSP_045399; 
# AltName	SCN1A_HUMAN	Sodium channel protein brain I subunit alpha
# AltName	SCN1A_HUMAN	Sodium channel protein type I subunit alpha
# AltName	SCN1A_HUMAN	Voltage-gated sodium channel subunit alpha Nav1.1
# BioGrid	112228	3
# CCDS	CCDS33316	-. [P35498-2]
# CCDS	CCDS54413	-. [P35498-1]
# CCDS	CCDS54414	-. [P35498-3]
# DISEASE	SCN1A_HUMAN	Epileptic encephalopathy, early infantile, 6 (EIEE6) [MIM 607208]  A severe form of epileptic encephalopathy characterized by generalized tonic, clonic, and tonic-clonic seizures that are initially induced by fever and begin during the first year of life. Later, patients also manifest other seizure types, including absence, myoclonic, and simple and complex partial seizures. Psychomotor development delay is observed around the second year of life. Some patients manifest a borderline disease phenotype and do not necessarily fulfill all diagnostic criteria for core EIEE6. EIEE6 is considered to be the most severe phenotype within the spectrum of generalized epilepsies with febrile seizures-plus. {ECO 0000269|PubMed 11359211, ECO 0000269|PubMed 12083760, ECO 0000269|PubMed 12566275, ECO 0000269|PubMed 12754708, ECO 0000269|PubMed 12821740, ECO 0000269|PubMed 14504318, ECO 0000269|PubMed 14738421, ECO 0000269|PubMed 15087100, ECO 0000269|PubMed 15944908, ECO 0000269|PubMed 16122630, ECO 0000269|PubMed 16458823, ECO 0000269|PubMed 16713920, ECO 0000269|PubMed 17054684, ECO 0000269|PubMed 17054685, ECO 0000269|PubMed 17129991, ECO 0000269|PubMed 17347258, ECO 0000269|PubMed 17561957, ECO 0000269|PubMed 18413471, ECO 0000269|PubMed 18639757, ECO 0000269|PubMed 18930999, ECO 0000269|PubMed 19522081, ECO 0000269|PubMed 19563458, ECO 0000269|PubMed 19589774, ECO 0000269|PubMed 19783390, ECO 0000269|PubMed 20110217, ECO 0000269|PubMed 20431604, ECO 0000269|PubMed 20452746, ECO 0000269|PubMed 20522430, ECO 0000269|PubMed 20729507, ECO 0000269|PubMed 21248271, ECO 0000269|PubMed 21864321, ECO 0000269|PubMed 22092154, ECO 0000269|PubMed 22612257, ECO 0000269|PubMed 23195492}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCN1A_HUMAN	Febrile seizures, familial, 3A (FEB3A) [MIM 604403]  Seizures associated with febrile episodes in childhood without any evidence of intracranial infection or defined pathologic or traumatic cause. It is a common condition, affecting 2-5% of children aged 3 months to 5 years. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy. {ECO 0000269|PubMed 16326807, ECO 0000269|PubMed 19522081}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCN1A_HUMAN	Generalized epilepsy with febrile seizures plus 2 (GEFS+2) [MIM 604403]  A rare autosomal dominant, familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. This disease combines febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity. {ECO 0000269|PubMed 10742094, ECO 0000269|PubMed 11254444, ECO 0000269|PubMed 11254445, ECO 0000269|PubMed 11524484, ECO 0000269|PubMed 11756608, ECO 0000269|PubMed 12535936, ECO 0000269|PubMed 12576172, ECO 0000269|PubMed 12919402, ECO 0000269|PubMed 14672992, ECO 0000269|PubMed 15525788, ECO 0000269|PubMed 15694566, ECO 0000269|PubMed 15715999, ECO 0000269|PubMed 16525050, ECO 0000269|PubMed 17347258, ECO 0000269|PubMed 17507202, ECO 0000269|PubMed 17561957, ECO 0000269|PubMed 17927801, ECO 0000269|PubMed 17928445, ECO 0000269|PubMed 18251839, ECO 0000269|PubMed 18413471, ECO 0000269|PubMed 18566737, ECO 0000269|PubMed 19339291, ECO 0000269|PubMed 19464195, ECO 0000269|PubMed 19522081, ECO 0000269|PubMed 20117752, ECO 0000269|PubMed 20550552, ECO 0000269|PubMed 20600615, ECO 0000269|PubMed 20729507, ECO 0000269|PubMed 21248271, ECO 0000269|PubMed 21864321}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCN1A_HUMAN	Intractable childhood epilepsy with generalized tonic- clonic seizures (ICEGTC) [MIM 607208]  A disorder characterized by generalized tonic-clonic seizures beginning usually in infancy and induced by fever. Seizures are associated with subsequent mental decline, as well as ataxia or hypotonia. ICEGTC is similar to SMEI, except for the absence of myoclonic seizures. {ECO 0000269|PubMed 12566275, ECO 0000269|PubMed 16210358, ECO 0000269|PubMed 17507202, ECO 0000269|PubMed 23195492}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCN1A_HUMAN	Migraine, familial hemiplegic, 3 (FHM3) [MIM 609634]  A subtype of migraine associated with transient blindness in some families. Migraine is a disabling symptom complex of periodic headaches, usually temporal and unilateral. Headaches are often accompanied by irritability, nausea, vomiting and photophobia, preceded by constriction of the cranial arteries. The two major subtypes are common migraine (migraine without aura) and classic migraine (migraine with aura). Classic migraine is characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as blurred vision, hallucinations, vertigo, numbness and difficulty in concentrating and speaking. {ECO 0000269|PubMed 16054936, ECO 0000269|PubMed 17397047, ECO 0000269|PubMed 18021921, ECO 0000269|PubMed 19332696}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCN1A_HUMAN	Note=SCN1A mutations may be involved in Panayiotopoulos syndrome, a benign age-related focal seizure disorder occurring in early and mid-childhood. It is characterized by seizures, often prolonged, with predominantly autonomic symptoms, and by an electroencephalogram that shows shifting and/or multiple foci, often with occipital predominance. Autonomic seizures in Panayiotopoulos syndrome consist of episodes of disturbed autonomic function with emesis as the predominant symptom. Cardiorespiratory arrest is exceptional. {ECO 0000269|PubMed 17679682, ECO 0000269|PubMed 19339291, ECO 0000269|PubMed 19522081}. 
# DOMAIN	SCN1A_HUMAN	The S3b-S4 and S1-S2 loops of repeat IV are targeted by H.maculata toxins Hm1a and Hm1b, leading to inhibit fast inactivation of Nav1.1/SCN1A. Selectivity for H.maculata toxins Hm1a and Hm1b depends on S1-S2 loops of repeat IV. {ECO 0000250|UniProtKB A2APX8}. 
# DOMAIN	SCN1A_HUMAN	The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position. 
# DrugBank	DB00252	Phenytoin
# DrugBank	DB00273	Topiramate
# DrugBank	DB00313	Valproic Acid
# DrugBank	DB00909	Zonisamide
# DrugBank	DB01121	Phenacemide
# DrugBank	DB01438	Phenazopyridine
# DrugBank	DB01595	Nitrazepam
# DrugBank	DB04855	Dronedarone
# DrugBank	DB04930	Permethrin
# ENZYME REGULATION	Specifically activated by the H.maculata toxins Hm1a and Hm1b in somatosensory neurons to elicit acute pain and mechanical allodynia. {ECO:0000250|UniProtKB	A2APX8}. 
# Ensembl	ENST00000303395	ENSP00000303540; ENSG00000144285. [P35498-1]
# Ensembl	ENST00000375405	ENSP00000364554; ENSG00000144285. [P35498-2]
# Ensembl	ENST00000409050	ENSP00000386312; ENSG00000144285. [P35498-3]
# Ensembl	ENST00000423058	ENSP00000407030; ENSG00000144285. [P35498-1]
# Ensembl	ENST00000635750	ENSP00000490799; ENSG00000144285. [P35498-2]
# Ensembl	ENST00000637988	ENSP00000490780; ENSG00000144285. [P35498-2]
# FUNCTION	SCN1A_HUMAN	Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons. Involved in sensory perception of mechanical pain  activation in somatosensory neurons induces pain without neurogenic inflammation and produces hypersensitivity to mechanical, but not thermal stimuli. {ECO 0000250|UniProtKB A2APX8}. 
# GO_component	GO:0001518	voltage-gated sodium channel complex; IEA:InterPro.
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0030018	Z disc; ISS:BHF-UCL.
# GO_function	GO:0005248	voltage-gated sodium channel activity; ISS:UniProtKB.
# GO_process	GO:0006814	sodium ion transport; ISS:UniProtKB.
# GO_process	GO:0019228	neuronal action potential; IBA:GO_Central.
# GO_process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain; ISS:UniProtKB.
# GO_process	GO:0086010	membrane depolarization during action potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.20.120.350	-; 4.
# Genevisible	P35498	HS
# HGNC	HGNC:10585	SCN1A
# IntAct	P35498	2
# InterPro	IPR001696	Na_channel_asu
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR008051	Na_channel_a1su
# InterPro	IPR010526	Na_trans_assoc
# InterPro	IPR024583	Na_trans_cytopl
# InterPro	IPR027359	Channel_four-helix_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00775	[Nervous system disease] Familial or sporadic hemiplegic migraine
# KEGG_Disease	H00783	[Nervous system disease; Epilepsy] Dravet syndrome/ Severe myoclonic epilepsy in infancy (SMEI)
# KEGG_Pathway	ko04728	Dopaminergic synapse
# MIM	182389	gene
# MIM	604403	phenotype
# MIM	607208	phenotype
# MIM	609634	phenotype
# Organism	SCN1A_HUMAN	Homo sapiens (Human)
# Orphanet	2382	Lennox-Gastaut syndrome
# Orphanet	293181	Malignant migrating partial seizures of infancy
# Orphanet	33069	Dravet syndrome
# Orphanet	36387	Generalized epilepsy with febrile seizures-plus
# Orphanet	569	Familial or sporadic hemiplegic migraine
# PIR	I52964	I52964
# PIR	S29184	S29184
# PRINTS	PR00170	NACHANNEL
# PRINTS	PR01664	NACHANNEL1
# PTM	SCN1A_HUMAN	Phosphorylation at Ser-1516 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents. {ECO 0000250|UniProtKB P04775}. 
# Pfam	PF00520	Ion_trans; 4
# Pfam	PF06512	Na_trans_assoc
# Pfam	PF11933	Na_trans_cytopl
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-445095	Interaction between L1 and Ankyrins
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# RecName	SCN1A_HUMAN	Sodium channel protein type 1 subunit alpha
# RefSeq	NP_001159435	NM_001165963.1. [P35498-1]
# RefSeq	NP_001159436	NM_001165964.1. [P35498-3]
# RefSeq	NP_001189364	NM_001202435.1. [P35498-1]
# RefSeq	NP_008851	NM_006920.4. [P35498-2]
# RefSeq	XP_011509904	XM_011511602.2. [P35498-1]
# RefSeq	XP_011509906	XM_011511604.2. [P35498-2]
# RefSeq	XP_011509908	XM_011511606.2. [P35498-3]
# RefSeq	XP_016860133	XM_017004644.1. [P35498-1]
# RefSeq	XP_016860134	XM_017004645.1. [P35498-2]
# RefSeq	XP_016860135	XM_017004646.1. [P35498-2]
# RefSeq	XP_016860136	XM_017004647.1. [P35498-2]
# RefSeq	XP_016860137	XM_017004648.1. [P35498-2]
# RefSeq	XP_016860138	XM_017004649.1. [P35498-2]
# RefSeq	XP_016860140	XM_017004651.1. [P35498-3]
# RefSeq	XP_016860141	XM_017004652.1. [P35498-3]
# SIMILARITY	Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.1/SCN1A subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 IQ domain. {ECO	0000305}.
# SUBCELLULAR LOCATION	SCN1A_HUMAN	Cell membrane {ECO 0000269|PubMed 17928445}; Multi-pass membrane protein {ECO 0000255}. 
# SUBUNIT	SCN1A_HUMAN	The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1 (SCN1B), beta-2 (SCN2B), beta-3 (SCN3B) and/or beta-3 (SCN4B). Beta-1 (SCN1B) and beta-3 (SCN3B) are non-covalently associated with alpha, while beta-2 (SCN2B) is covalently linked by disulfide bonds. Interacts with FGF13; may regulate SCN1A activity (PubMed 21566136). Interacts with SCN1B (PubMed 17928445, PubMed 15525788). {ECO 0000269|PubMed 15525788, ECO 0000269|PubMed 17928445, ECO 0000269|PubMed 21566136}. 
# TCDB	1.A.1.10	the voltage-gated ion channel (vic) superfamily
# UCSC	uc061pes	human. [P35498-1]
# eggNOG	COG1226	LUCA
# eggNOG	ENOG410INF8	Eukaryota
BLAST	swissprot:SCN1A_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SCN1A_HUMAN
BioCyc	ZFISH:ENSG00000144285-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000144285-MONOMER
COXPRESdb	6323	http://coxpresdb.jp/data/gene/6323.shtml
CleanEx	HS_SCN1A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SCN1A
DIP	DIP-59851N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-59851N
DOI	10.1001/archneur.65.4.489	http://dx.doi.org/10.1001/archneur.65.4.489
DOI	10.1002/humu.10217	http://dx.doi.org/10.1002/humu.10217
DOI	10.1002/humu.9486	http://dx.doi.org/10.1002/humu.9486
DOI	10.1007/s10038-008-0306-y	http://dx.doi.org/10.1007/s10038-008-0306-y
DOI	10.1016/0014-5793(92)80476-W	http://dx.doi.org/10.1016/0014-5793(92)80476-W
DOI	10.1016/S0006-291X(02)00617-4	http://dx.doi.org/10.1016/S0006-291X(02)00617-4
DOI	10.1016/S0140-6736(05)66786-4	http://dx.doi.org/10.1016/S0140-6736(05)66786-4
DOI	10.1016/S0306-4522(02)00698-X	http://dx.doi.org/10.1016/S0306-4522(02)00698-X
DOI	10.1016/S0920-1211(02)00259-0	http://dx.doi.org/10.1016/S0920-1211(02)00259-0
DOI	10.1016/S1474-4422(06)70446-X	http://dx.doi.org/10.1016/S1474-4422(06)70446-X
DOI	10.1016/j.arcmed.2010.04.007	http://dx.doi.org/10.1016/j.arcmed.2010.04.007
DOI	10.1016/j.braindev.2004.11.005	http://dx.doi.org/10.1016/j.braindev.2004.11.005
DOI	10.1016/j.braindev.2009.08.009	http://dx.doi.org/10.1016/j.braindev.2009.08.009
DOI	10.1016/j.ejpn.2010.03.002	http://dx.doi.org/10.1016/j.ejpn.2010.03.002
DOI	10.1016/j.eplepsyres.2004.11.005	http://dx.doi.org/10.1016/j.eplepsyres.2004.11.005
DOI	10.1016/j.eplepsyres.2007.03.018	http://dx.doi.org/10.1016/j.eplepsyres.2007.03.018
DOI	10.1016/j.eplepsyres.2010.04.003	http://dx.doi.org/10.1016/j.eplepsyres.2010.04.003
DOI	10.1016/j.eplepsyres.2012.06.006	http://dx.doi.org/10.1016/j.eplepsyres.2012.06.006
DOI	10.1016/j.eplepsyres.2015.08.001	http://dx.doi.org/10.1016/j.eplepsyres.2015.08.001
DOI	10.1016/j.neulet.2010.06.040	http://dx.doi.org/10.1016/j.neulet.2010.06.040
DOI	10.1016/j.pediatrneurol.2003.10.012	http://dx.doi.org/10.1016/j.pediatrneurol.2003.10.012
DOI	10.1016/j.pediatrneurol.2005.07.009	http://dx.doi.org/10.1016/j.pediatrneurol.2005.07.009
DOI	10.1016/j.pediatrneurol.2007.06.016	http://dx.doi.org/10.1016/j.pediatrneurol.2007.06.016
DOI	10.1016/j.pediatrneurol.2008.04.003	http://dx.doi.org/10.1016/j.pediatrneurol.2008.04.003
DOI	10.1016/j.pediatrneurol.2009.09.007	http://dx.doi.org/10.1016/j.pediatrneurol.2009.09.007
DOI	10.1016/j.seizure.2004.12.007	http://dx.doi.org/10.1016/j.seizure.2004.12.007
DOI	10.1016/j.seizure.2009.04.009	http://dx.doi.org/10.1016/j.seizure.2009.04.009
DOI	10.1038/74159	http://dx.doi.org/10.1038/74159
DOI	10.1038/jhg.2010.39	http://dx.doi.org/10.1038/jhg.2010.39
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/sj.mp.4001241	http://dx.doi.org/10.1038/sj.mp.4001241
DOI	10.1046/j.1528-1157.2003.22503.x	http://dx.doi.org/10.1046/j.1528-1157.2003.22503.x
DOI	10.1055/s-2005-865607	http://dx.doi.org/10.1055/s-2005-865607
DOI	10.1055/s-2008-1062703	http://dx.doi.org/10.1055/s-2008-1062703
DOI	10.1073/pnas.0506818102	http://dx.doi.org/10.1073/pnas.0506818102
DOI	10.1074/jbc.M111.245803	http://dx.doi.org/10.1074/jbc.M111.245803
DOI	10.1080/08035250600778628	http://dx.doi.org/10.1080/08035250600778628
DOI	10.1086/319516	http://dx.doi.org/10.1086/319516
DOI	10.1086/319524	http://dx.doi.org/10.1086/319524
DOI	10.1086/320609	http://dx.doi.org/10.1086/320609
DOI	10.1093/brain/awg053	http://dx.doi.org/10.1093/brain/awg053
DOI	10.1093/brain/awm002	http://dx.doi.org/10.1093/brain/awm002
DOI	10.1111/j.0013-9580.2004.15103.x	http://dx.doi.org/10.1111/j.0013-9580.2004.15103.x
DOI	10.1111/j.1365-2125.2009.03437.x	http://dx.doi.org/10.1111/j.1365-2125.2009.03437.x
DOI	10.1111/j.1399-0004.2009.01155.x	http://dx.doi.org/10.1111/j.1399-0004.2009.01155.x
DOI	10.1111/j.1442-200X.2009.02916.x	http://dx.doi.org/10.1111/j.1442-200X.2009.02916.x
DOI	10.1111/j.1460-9568.2011.07826.x	http://dx.doi.org/10.1111/j.1460-9568.2011.07826.x
DOI	10.1111/j.1528-1167.2006.00641.x	http://dx.doi.org/10.1111/j.1528-1167.2006.00641.x
DOI	10.1111/j.1528-1167.2006.00643.x	http://dx.doi.org/10.1111/j.1528-1167.2006.00643.x
DOI	10.1111/j.1528-1167.2007.01122.x	http://dx.doi.org/10.1111/j.1528-1167.2007.01122.x
DOI	10.1111/j.1528-1167.2007.01411.x	http://dx.doi.org/10.1111/j.1528-1167.2007.01411.x
DOI	10.1111/j.1528-1167.2007.01439_2.x	http://dx.doi.org/10.1111/j.1528-1167.2007.01439_2.x
DOI	10.1111/j.1528-1167.2010.02645.x	http://dx.doi.org/10.1111/j.1528-1167.2010.02645.x
DOI	10.1111/j.1528-1167.2011.03311.x	http://dx.doi.org/10.1111/j.1528-1167.2011.03311.x
DOI	10.1111/j.1528-1167.2011.03402.x	http://dx.doi.org/10.1111/j.1528-1167.2011.03402.x
DOI	10.1111/j.1528-1167.2012.03516.x	http://dx.doi.org/10.1111/j.1528-1167.2012.03516.x
DOI	10.1111/j.1600-0404.2007.00941.x	http://dx.doi.org/10.1111/j.1600-0404.2007.00941.x
DOI	10.1113/jphysiol.2005.094326	http://dx.doi.org/10.1113/jphysiol.2005.094326
DOI	10.1136/jmg.2008.062323	http://dx.doi.org/10.1136/jmg.2008.062323
DOI	10.1136/jmg.2008.065912	http://dx.doi.org/10.1136/jmg.2008.065912
DOI	10.1136/jmg.2009.074328	http://dx.doi.org/10.1136/jmg.2009.074328
DOI	10.1177/0883073808324537	http://dx.doi.org/10.1177/0883073808324537
DOI	10.1177/0883073809357241	http://dx.doi.org/10.1177/0883073809357241
DOI	10.1177/0883073810365737	http://dx.doi.org/10.1177/0883073810365737
DOI	10.1212/01.WNL.0000069463.41870.2F	http://dx.doi.org/10.1212/01.WNL.0000069463.41870.2F
DOI	10.1212/01.WNL.0000086379.71183.78	http://dx.doi.org/10.1212/01.WNL.0000086379.71183.78
DOI	10.1212/01.wnl.0000266666.10404.53	http://dx.doi.org/10.1212/01.wnl.0000266666.10404.53
DOI	10.1212/01.wnl.0000345393.53132.8c	http://dx.doi.org/10.1212/01.wnl.0000345393.53132.8c
DOI	10.1212/WNL.0b013e31820c309b	http://dx.doi.org/10.1212/WNL.0b013e31820c309b
DOI	10.1212/WNL.57.12.2265	http://dx.doi.org/10.1212/WNL.57.12.2265
DOI	10.1212/WNL.57.4.703	http://dx.doi.org/10.1212/WNL.57.4.703
DOI	10.1523/JNEUROSCI.2034-04.2004	http://dx.doi.org/10.1523/JNEUROSCI.2034-04.2004
DOI	10.1523/JNEUROSCI.2977-05.2006	http://dx.doi.org/10.1523/JNEUROSCI.2977-05.2006
DOI	10.1523/JNEUROSCI.3515-07.2007	http://dx.doi.org/10.1523/JNEUROSCI.3515-07.2007
DrugBank	DB00252	http://www.drugbank.ca/drugs/DB00252
DrugBank	DB00273	http://www.drugbank.ca/drugs/DB00273
DrugBank	DB00313	http://www.drugbank.ca/drugs/DB00313
DrugBank	DB00909	http://www.drugbank.ca/drugs/DB00909
DrugBank	DB01121	http://www.drugbank.ca/drugs/DB01121
DrugBank	DB01438	http://www.drugbank.ca/drugs/DB01438
DrugBank	DB01595	http://www.drugbank.ca/drugs/DB01595
DrugBank	DB04855	http://www.drugbank.ca/drugs/DB04855
DrugBank	DB04930	http://www.drugbank.ca/drugs/DB04930
EMBL	AB093548	http://www.ebi.ac.uk/ena/data/view/AB093548
EMBL	AB093549	http://www.ebi.ac.uk/ena/data/view/AB093549
EMBL	AB098335	http://www.ebi.ac.uk/ena/data/view/AB098335
EMBL	AC010127	http://www.ebi.ac.uk/ena/data/view/AC010127
EMBL	AF225985	http://www.ebi.ac.uk/ena/data/view/AF225985
EMBL	AY043484	http://www.ebi.ac.uk/ena/data/view/AY043484
EMBL	M91803	http://www.ebi.ac.uk/ena/data/view/M91803
EMBL	S71446	http://www.ebi.ac.uk/ena/data/view/S71446
EMBL	X65362	http://www.ebi.ac.uk/ena/data/view/X65362
Ensembl	ENST00000303395	http://www.ensembl.org/id/ENST00000303395
Ensembl	ENST00000375405	http://www.ensembl.org/id/ENST00000375405
Ensembl	ENST00000409050	http://www.ensembl.org/id/ENST00000409050
Ensembl	ENST00000423058	http://www.ensembl.org/id/ENST00000423058
Ensembl	ENST00000635750	http://www.ensembl.org/id/ENST00000635750
Ensembl	ENST00000637988	http://www.ensembl.org/id/ENST00000637988
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0001518	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001518
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0030018	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030018
GO_function	GO:0005248	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005248
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0019228	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019228
GO_process	GO:0050966	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050966
GO_process	GO:0086010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086010
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	SCN1A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SCN1A
GeneID	6323	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6323
GeneTree	ENSGT00830000128242	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00830000128242
HGNC	HGNC:10585	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10585
HOGENOM	HOG000231755	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231755&db=HOGENOM6
HOVERGEN	HBG053100	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053100&db=HOVERGEN
InParanoid	P35498	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P35498
IntAct	P35498	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P35498*
InterPro	IPR001696	http://www.ebi.ac.uk/interpro/entry/IPR001696
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR008051	http://www.ebi.ac.uk/interpro/entry/IPR008051
InterPro	IPR010526	http://www.ebi.ac.uk/interpro/entry/IPR010526
InterPro	IPR024583	http://www.ebi.ac.uk/interpro/entry/IPR024583
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
Jabion	6323	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6323
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00775	http://www.genome.jp/dbget-bin/www_bget?H00775
KEGG_Disease	H00783	http://www.genome.jp/dbget-bin/www_bget?H00783
KEGG_Gene	hsa:6323	http://www.genome.jp/dbget-bin/www_bget?hsa:6323
KEGG_Orthology	KO:K04833	http://www.genome.jp/dbget-bin/www_bget?KO:K04833
KEGG_Pathway	ko04728	http://www.genome.jp/kegg-bin/show_pathway?ko04728
MIM	182389	http://www.ncbi.nlm.nih.gov/omim/182389
MIM	604403	http://www.ncbi.nlm.nih.gov/omim/604403
MIM	607208	http://www.ncbi.nlm.nih.gov/omim/607208
MIM	609634	http://www.ncbi.nlm.nih.gov/omim/609634
MINT	MINT-6542725	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6542725
OMA	DNCMSNH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DNCMSNH
Orphanet	2382	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=2382
Orphanet	293181	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=293181
Orphanet	33069	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=33069
Orphanet	36387	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=36387
Orphanet	569	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=569
OrthoDB	EOG091G00FK	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00FK
PRINTS	PR00170	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00170
PRINTS	PR01664	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01664
PSORT	swissprot:SCN1A_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SCN1A_HUMAN
PSORT-B	swissprot:SCN1A_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SCN1A_HUMAN
PSORT2	swissprot:SCN1A_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SCN1A_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF06512	http://pfam.xfam.org/family/PF06512
Pfam	PF11933	http://pfam.xfam.org/family/PF11933
PharmGKB	PA301	http://www.pharmgkb.org/do/serve?objId=PA301&objCls=Gene
Phobius	swissprot:SCN1A_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SCN1A_HUMAN
PhylomeDB	P35498	http://phylomedb.org/?seqid=P35498
ProteinModelPortal	P35498	http://www.proteinmodelportal.org/query/uniprot/P35498
PubMed	10742094	http://www.ncbi.nlm.nih.gov/pubmed/10742094
PubMed	11254444	http://www.ncbi.nlm.nih.gov/pubmed/11254444
PubMed	11254445	http://www.ncbi.nlm.nih.gov/pubmed/11254445
PubMed	11359211	http://www.ncbi.nlm.nih.gov/pubmed/11359211
PubMed	11524484	http://www.ncbi.nlm.nih.gov/pubmed/11524484
PubMed	11756608	http://www.ncbi.nlm.nih.gov/pubmed/11756608
PubMed	12083760	http://www.ncbi.nlm.nih.gov/pubmed/12083760
PubMed	12535936	http://www.ncbi.nlm.nih.gov/pubmed/12535936
PubMed	12566275	http://www.ncbi.nlm.nih.gov/pubmed/12566275
PubMed	12576172	http://www.ncbi.nlm.nih.gov/pubmed/12576172
PubMed	12610651	http://www.ncbi.nlm.nih.gov/pubmed/12610651
PubMed	12754708	http://www.ncbi.nlm.nih.gov/pubmed/12754708
PubMed	12821740	http://www.ncbi.nlm.nih.gov/pubmed/12821740
PubMed	12919402	http://www.ncbi.nlm.nih.gov/pubmed/12919402
PubMed	1317301	http://www.ncbi.nlm.nih.gov/pubmed/1317301
PubMed	14504318	http://www.ncbi.nlm.nih.gov/pubmed/14504318
PubMed	14672992	http://www.ncbi.nlm.nih.gov/pubmed/14672992
PubMed	14738421	http://www.ncbi.nlm.nih.gov/pubmed/14738421
PubMed	15087100	http://www.ncbi.nlm.nih.gov/pubmed/15087100
PubMed	15525788	http://www.ncbi.nlm.nih.gov/pubmed/15525788
PubMed	15694566	http://www.ncbi.nlm.nih.gov/pubmed/15694566
PubMed	15715999	http://www.ncbi.nlm.nih.gov/pubmed/15715999
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	15944908	http://www.ncbi.nlm.nih.gov/pubmed/15944908
PubMed	16054936	http://www.ncbi.nlm.nih.gov/pubmed/16054936
PubMed	16122630	http://www.ncbi.nlm.nih.gov/pubmed/16122630
PubMed	16210358	http://www.ncbi.nlm.nih.gov/pubmed/16210358
PubMed	16326807	http://www.ncbi.nlm.nih.gov/pubmed/16326807
PubMed	16458823	http://www.ncbi.nlm.nih.gov/pubmed/16458823
PubMed	16525050	http://www.ncbi.nlm.nih.gov/pubmed/16525050
PubMed	16713920	http://www.ncbi.nlm.nih.gov/pubmed/16713920
PubMed	17054684	http://www.ncbi.nlm.nih.gov/pubmed/17054684
PubMed	17054685	http://www.ncbi.nlm.nih.gov/pubmed/17054685
PubMed	17129991	http://www.ncbi.nlm.nih.gov/pubmed/17129991
PubMed	17347258	http://www.ncbi.nlm.nih.gov/pubmed/17347258
PubMed	17397047	http://www.ncbi.nlm.nih.gov/pubmed/17397047
PubMed	17507202	http://www.ncbi.nlm.nih.gov/pubmed/17507202
PubMed	17561957	http://www.ncbi.nlm.nih.gov/pubmed/17561957
PubMed	17679682	http://www.ncbi.nlm.nih.gov/pubmed/17679682
PubMed	17927801	http://www.ncbi.nlm.nih.gov/pubmed/17927801
PubMed	17928445	http://www.ncbi.nlm.nih.gov/pubmed/17928445
PubMed	18021921	http://www.ncbi.nlm.nih.gov/pubmed/18021921
PubMed	18031552	http://www.ncbi.nlm.nih.gov/pubmed/18031552
PubMed	18251839	http://www.ncbi.nlm.nih.gov/pubmed/18251839
PubMed	18330841	http://www.ncbi.nlm.nih.gov/pubmed/18330841
PubMed	18413471	http://www.ncbi.nlm.nih.gov/pubmed/18413471
PubMed	18566737	http://www.ncbi.nlm.nih.gov/pubmed/18566737
PubMed	18639757	http://www.ncbi.nlm.nih.gov/pubmed/18639757
PubMed	18930999	http://www.ncbi.nlm.nih.gov/pubmed/18930999
PubMed	19332696	http://www.ncbi.nlm.nih.gov/pubmed/19332696
PubMed	19339291	http://www.ncbi.nlm.nih.gov/pubmed/19339291
PubMed	19464195	http://www.ncbi.nlm.nih.gov/pubmed/19464195
PubMed	19522081	http://www.ncbi.nlm.nih.gov/pubmed/19522081
PubMed	19563458	http://www.ncbi.nlm.nih.gov/pubmed/19563458
PubMed	19589774	http://www.ncbi.nlm.nih.gov/pubmed/19589774
PubMed	19694741	http://www.ncbi.nlm.nih.gov/pubmed/19694741
PubMed	19783390	http://www.ncbi.nlm.nih.gov/pubmed/19783390
PubMed	20110217	http://www.ncbi.nlm.nih.gov/pubmed/20110217
PubMed	20117752	http://www.ncbi.nlm.nih.gov/pubmed/20117752
PubMed	20392657	http://www.ncbi.nlm.nih.gov/pubmed/20392657
PubMed	20431604	http://www.ncbi.nlm.nih.gov/pubmed/20431604
PubMed	20452746	http://www.ncbi.nlm.nih.gov/pubmed/20452746
PubMed	20522430	http://www.ncbi.nlm.nih.gov/pubmed/20522430
PubMed	20550552	http://www.ncbi.nlm.nih.gov/pubmed/20550552
PubMed	20600615	http://www.ncbi.nlm.nih.gov/pubmed/20600615
PubMed	20682179	http://www.ncbi.nlm.nih.gov/pubmed/20682179
PubMed	20729507	http://www.ncbi.nlm.nih.gov/pubmed/20729507
PubMed	21248271	http://www.ncbi.nlm.nih.gov/pubmed/21248271
PubMed	21566136	http://www.ncbi.nlm.nih.gov/pubmed/21566136
PubMed	21864321	http://www.ncbi.nlm.nih.gov/pubmed/21864321
PubMed	22092154	http://www.ncbi.nlm.nih.gov/pubmed/22092154
PubMed	22309220	http://www.ncbi.nlm.nih.gov/pubmed/22309220
PubMed	22612257	http://www.ncbi.nlm.nih.gov/pubmed/22612257
PubMed	23195492	http://www.ncbi.nlm.nih.gov/pubmed/23195492
PubMed	26311622	http://www.ncbi.nlm.nih.gov/pubmed/26311622
PubMed	8062593	http://www.ncbi.nlm.nih.gov/pubmed/8062593
Reactome	R-HSA-445095	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-445095
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
RefSeq	NP_001159435	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001159435
RefSeq	NP_001159436	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001159436
RefSeq	NP_001189364	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001189364
RefSeq	NP_008851	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_008851
RefSeq	XP_011509904	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011509904
RefSeq	XP_011509906	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011509906
RefSeq	XP_011509908	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011509908
RefSeq	XP_016860133	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016860133
RefSeq	XP_016860134	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016860134
RefSeq	XP_016860135	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016860135
RefSeq	XP_016860136	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016860136
RefSeq	XP_016860137	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016860137
RefSeq	XP_016860138	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016860138
RefSeq	XP_016860140	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016860140
RefSeq	XP_016860141	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016860141
STRING	9606.ENSP00000303540	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000303540&targetmode=cogs
TCDB	1.A.1.10	http://www.tcdb.org/search/result.php?tc=1.A.1.10
UCSC	uc061pes	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc061pes&org=rat
UniGene	Hs.22654	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.22654
UniGene	Hs.629873	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.629873
UniGene	Hs.693440	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.693440
UniGene	Hs.740081	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.740081
UniProtKB	SCN1A_HUMAN	http://www.uniprot.org/uniprot/SCN1A_HUMAN
UniProtKB-AC	P35498	http://www.uniprot.org/uniprot/P35498
charge	swissprot:SCN1A_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SCN1A_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	ENOG410INF8	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410INF8
epestfind	swissprot:SCN1A_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SCN1A_HUMAN
garnier	swissprot:SCN1A_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SCN1A_HUMAN
helixturnhelix	swissprot:SCN1A_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SCN1A_HUMAN
hmoment	swissprot:SCN1A_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SCN1A_HUMAN
iep	swissprot:SCN1A_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SCN1A_HUMAN
inforesidue	swissprot:SCN1A_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SCN1A_HUMAN
neXtProt	NX_P35498	http://www.nextprot.org/db/entry/NX_P35498
octanol	swissprot:SCN1A_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SCN1A_HUMAN
pepcoil	swissprot:SCN1A_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SCN1A_HUMAN
pepdigest	swissprot:SCN1A_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SCN1A_HUMAN
pepinfo	swissprot:SCN1A_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SCN1A_HUMAN
pepnet	swissprot:SCN1A_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SCN1A_HUMAN
pepstats	swissprot:SCN1A_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SCN1A_HUMAN
pepwheel	swissprot:SCN1A_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SCN1A_HUMAN
pepwindow	swissprot:SCN1A_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SCN1A_HUMAN
sigcleave	swissprot:SCN1A_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SCN1A_HUMAN
## Database	ID	URL or Descriptions
# AltName	ZNT4_HUMAN	Solute carrier family 30 member 4
# BioGrid	113563	21
# ChiTaRS	SLC30A4	human
# DOMAIN	ZNT4_HUMAN	Contains a histidine-rich region which is a ligand for zinc and an aspartate-rich region which is a potential ligand for zinc. {ECO 0000250}. 
# Ensembl	ENST00000261867	ENSP00000261867; ENSG00000104154
# FUNCTION	ZNT4_HUMAN	Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular compartment. 
# GO_component	GO:0005737	cytoplasm; IDA:BHF-UCL.
# GO_component	GO:0005765	lysosomal membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005770	late endosome; IDA:BHF-UCL.
# GO_component	GO:0016020	membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0016023	cytoplasmic, membrane-bounded vesicle; IBA:GO_Central.
# GO_component	GO:0031902	late endosome membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0005385	zinc ion transmembrane transporter activity; TAS:ProtInc.
# GO_process	GO:0009636	response to toxic substance; IDA:UniProtKB.
# GO_process	GO:0010043	response to zinc ion; IBA:GO_Central.
# GO_process	GO:0055069	zinc ion homeostasis; IEA:Ensembl.
# GO_process	GO:0061088	regulation of sequestering of zinc ion; IDA:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005768	endosome
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# Gene3D	1.20.1510.10	-; 1.
# Genevisible	O14863	HS
# HGNC	HGNC:11015	SLC30A4
# InterPro	IPR002524	Cation_efflux
# InterPro	IPR027469	Cation_efflux_TMD
# KEGG_Brite	ko02001	Solute carrier family
# MIM	602095	gene
# Organism	ZNT4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11562	PTHR11562
# Pfam	PF01545	Cation_efflux
# Proteomes	UP000005640	Chromosome 15
# RecName	ZNT4_HUMAN	Zinc transporter 4
# RefSeq	NP_037441	NM_013309.5
# RefSeq	XP_011520299	XM_011521997.2
# RefSeq	XP_016878049	XM_017022560.1
# SIMILARITY	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	ZNT4_HUMAN	Endosome membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. Late endosome membrane {ECO 0000269|PubMed 17349999}; Multi-pass membrane protein {ECO 0000255}. Lysosome membrane {ECO 0000269|PubMed 17349999}; Multi-pass membrane protein {ECO 0000255}. 
# TCDB	2.A.4.3	the cation diffusion facilitator (cdf) family
# TIGRFAMs	TIGR01297	CDF
# UCSC	uc001zvj	human
# eggNOG	COG1230	LUCA
# eggNOG	KOG1482	Eukaryota
BLAST	swissprot:ZNT4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ZNT4_HUMAN
BioCyc	ZFISH:ENSG00000104154-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000104154-MONOMER
COXPRESdb	7782	http://coxpresdb.jp/data/gene/7782.shtml
CleanEx	HS_SLC30A4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC30A4
DOI	10.1016/j.yexcr.2007.02.006	http://dx.doi.org/10.1016/j.yexcr.2007.02.006
DOI	10.1038/ng1197-292	http://dx.doi.org/10.1038/ng1197-292
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF025409	http://www.ebi.ac.uk/ena/data/view/AF025409
EMBL	AK290874	http://www.ebi.ac.uk/ena/data/view/AK290874
EMBL	BC026089	http://www.ebi.ac.uk/ena/data/view/BC026089
EMBL	CH471082	http://www.ebi.ac.uk/ena/data/view/CH471082
Ensembl	ENST00000261867	http://www.ensembl.org/id/ENST00000261867
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005770	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005770
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016023	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016023
GO_component	GO:0031902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031902
GO_function	GO:0005385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005385
GO_process	GO:0009636	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009636
GO_process	GO:0010043	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010043
GO_process	GO:0055069	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055069
GO_process	GO:0061088	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061088
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
Gene3D	1.20.1510.10	http://www.cathdb.info/version/latest/superfamily/1.20.1510.10
GeneCards	SLC30A4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC30A4
GeneID	7782	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7782
GeneTree	ENSGT00550000074381	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074381
H-InvDB	HIX0012212	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0012212
HGNC	HGNC:11015	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11015
HOGENOM	HOG000079023	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000079023&db=HOGENOM6
HOVERGEN	HBG003345	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003345&db=HOVERGEN
HPA	HPA018178	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA018178
InParanoid	O14863	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O14863
InterPro	IPR002524	http://www.ebi.ac.uk/interpro/entry/IPR002524
InterPro	IPR027469	http://www.ebi.ac.uk/interpro/entry/IPR027469
Jabion	7782	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7782
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:7782	http://www.genome.jp/dbget-bin/www_bget?hsa:7782
KEGG_Orthology	KO:K14691	http://www.genome.jp/dbget-bin/www_bget?KO:K14691
MIM	602095	http://www.ncbi.nlm.nih.gov/omim/602095
OMA	HTYGWHN	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HTYGWHN
OrthoDB	EOG091G07UN	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07UN
PANTHER	PTHR11562	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11562
PSORT	swissprot:ZNT4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ZNT4_HUMAN
PSORT-B	swissprot:ZNT4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ZNT4_HUMAN
PSORT2	swissprot:ZNT4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ZNT4_HUMAN
Pfam	PF01545	http://pfam.xfam.org/family/PF01545
PharmGKB	PA35885	http://www.pharmgkb.org/do/serve?objId=PA35885&objCls=Gene
Phobius	swissprot:ZNT4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ZNT4_HUMAN
PhylomeDB	O14863	http://phylomedb.org/?seqid=O14863
ProteinModelPortal	O14863	http://www.proteinmodelportal.org/query/uniprot/O14863
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17349999	http://www.ncbi.nlm.nih.gov/pubmed/17349999
PubMed	9354792	http://www.ncbi.nlm.nih.gov/pubmed/9354792
RefSeq	NP_037441	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_037441
RefSeq	XP_011520299	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011520299
RefSeq	XP_016878049	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016878049
STRING	9606.ENSP00000261867	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000261867&targetmode=cogs
TCDB	2.A.4.3	http://www.tcdb.org/search/result.php?tc=2.A.4.3
TIGRFAMs	TIGR01297	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01297
UCSC	uc001zvj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001zvj&org=rat
UniGene	Hs.162989	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.162989
UniGene	Hs.375762	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.375762
UniProtKB	ZNT4_HUMAN	http://www.uniprot.org/uniprot/ZNT4_HUMAN
UniProtKB-AC	O14863	http://www.uniprot.org/uniprot/O14863
charge	swissprot:ZNT4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ZNT4_HUMAN
eggNOG	COG1230	http://eggnogapi.embl.de/nog_data/html/tree/COG1230
eggNOG	KOG1482	http://eggnogapi.embl.de/nog_data/html/tree/KOG1482
epestfind	swissprot:ZNT4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ZNT4_HUMAN
garnier	swissprot:ZNT4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ZNT4_HUMAN
helixturnhelix	swissprot:ZNT4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZNT4_HUMAN
hmoment	swissprot:ZNT4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ZNT4_HUMAN
iep	swissprot:ZNT4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ZNT4_HUMAN
inforesidue	swissprot:ZNT4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ZNT4_HUMAN
neXtProt	NX_O14863	http://www.nextprot.org/db/entry/NX_O14863
octanol	swissprot:ZNT4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ZNT4_HUMAN
pepcoil	swissprot:ZNT4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ZNT4_HUMAN
pepdigest	swissprot:ZNT4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ZNT4_HUMAN
pepinfo	swissprot:ZNT4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ZNT4_HUMAN
pepnet	swissprot:ZNT4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ZNT4_HUMAN
pepstats	swissprot:ZNT4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ZNT4_HUMAN
pepwheel	swissprot:ZNT4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ZNT4_HUMAN
pepwindow	swissprot:ZNT4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ZNT4_HUMAN
sigcleave	swissprot:ZNT4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ZNT4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	VGLU3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8NDX2-1; Sequence=Displayed; Name=2; IsoId=Q8NDX2-2; Sequence=VSP_033265; Note=No experimental confirmation available.; 
# AltName	VGLU3_HUMAN	Solute carrier family 17 member 8
# CCDS	CCDS44957	-. [Q8NDX2-2]
# CCDS	CCDS9077	-. [Q8NDX2-1]
# CDD	cd06174	MFS
# DISEASE	VGLU3_HUMAN	Deafness, autosomal dominant, 25 (DFNA25) [MIM 605583]  A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA25 expression is variable in terms of onset and rate of progression, with an age-dependent penetrance resembling an early-onset presbycusis, or senile deafness, a progressive bilateral loss of hearing that occurs in the aged. {ECO 0000269|PubMed 18674745}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000323346	ENSP00000316909; ENSG00000179520. [Q8NDX2-1]
# Ensembl	ENST00000392989	ENSP00000376715; ENSG00000179520. [Q8NDX2-2]
# FUNCTION	VGLU3_HUMAN	Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. {ECO 0000269|PubMed 12151341}. 
# GO_component	GO:0005771	multivesicular body; IEA:Ensembl.
# GO_component	GO:0016021	integral component of membrane; IBA:GO_Central.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030672	synaptic vesicle membrane; IBA:GO_Central.
# GO_component	GO:0043204	perikaryon; IEA:Ensembl.
# GO_component	GO:0043679	axon terminus; IEA:Ensembl.
# GO_component	GO:0060076	excitatory synapse; IEA:Ensembl.
# GO_component	GO:0097440	apical dendrite; IEA:Ensembl.
# GO_component	GO:0097441	basilar dendrite; IEA:Ensembl.
# GO_component	GO:0097451	glial limiting end-foot; IEA:Ensembl.
# GO_component	GO:1990030	pericellular basket; IEA:Ensembl.
# GO_function	GO:0005313	L-glutamate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_process	GO:0003407	neural retina development; IEA:Ensembl.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006814	sodium ion transport; IEA:UniProtKB-KW.
# GO_process	GO:0006836	neurotransmitter transport; IEA:UniProtKB-KW.
# GO_process	GO:0007420	brain development; IEA:Ensembl.
# GO_process	GO:0007605	sensory perception of sound; IEA:UniProtKB-KW.
# GO_process	GO:0090102	cochlea development; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005768	endosome
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# Genevisible	Q8NDX2	HS
# HGNC	HGNC:20151	SLC17A8
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H00604	[Nervous system disease; Nervous system disease] Deafness, autosomal dominant
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04724	Glutamatergic synapse
# KEGG_Pathway	ko05033	Nicotine addiction
# MIM	605583	phenotype
# MIM	607557	gene
# Organism	VGLU3_HUMAN	Homo sapiens (Human)
# Orphanet	90635	Autosomal dominant non-syndromic sensorineural deafness type DFNA
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-428643	Organic anion transporters
# RecName	VGLU3_HUMAN	Vesicular glutamate transporter 3
# RefSeq	NP_001138760	NM_001145288.1. [Q8NDX2-2]
# RefSeq	NP_647480	NM_139319.2. [Q8NDX2-1]
# SIMILARITY	Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	VGLU3_HUMAN	Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO 0000250|UniProtKB Q7TSF2}. Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. Cell junction, synapse, synaptosome {ECO 0000250|UniProtKB Q7TSF2}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.14.32	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	Expressed in amygdala, cerebellum, hippocampus, medulla, spinal cord and thalamus. {ECO:0000269|PubMed	12151341}. 
# UCSC	uc009ztx	human. [Q8NDX2-1]
# eggNOG	ENOG410XPWC	LUCA
# eggNOG	KOG2532	Eukaryota
BLAST	swissprot:VGLU3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VGLU3_HUMAN
BioCyc	ZFISH:ENSG00000179520-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000179520-MONOMER
COXPRESdb	246213	http://coxpresdb.jp/data/gene/246213.shtml
CleanEx	HS_SLC17A8	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC17A8
DOI	10.1016/j.ajhg.2008.07.008	http://dx.doi.org/10.1016/j.ajhg.2008.07.008
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/embo-reports/kvf159	http://dx.doi.org/10.1093/embo-reports/kvf159
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AJ459241	http://www.ebi.ac.uk/ena/data/view/AJ459241
EMBL	AK128319	http://www.ebi.ac.uk/ena/data/view/AK128319
EMBL	BC117229	http://www.ebi.ac.uk/ena/data/view/BC117229
EMBL	BC143396	http://www.ebi.ac.uk/ena/data/view/BC143396
EMBL	CH471054	http://www.ebi.ac.uk/ena/data/view/CH471054
Ensembl	ENST00000323346	http://www.ensembl.org/id/ENST00000323346
Ensembl	ENST00000392989	http://www.ensembl.org/id/ENST00000392989
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005771	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005771
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030672	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030672
GO_component	GO:0043204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043204
GO_component	GO:0043679	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043679
GO_component	GO:0060076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060076
GO_component	GO:0097440	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097440
GO_component	GO:0097441	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097441
GO_component	GO:0097451	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097451
GO_component	GO:1990030	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990030
GO_function	GO:0005313	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005313
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_process	GO:0003407	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003407
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0006836	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006836
GO_process	GO:0007420	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007420
GO_process	GO:0007605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007605
GO_process	GO:0090102	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090102
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	SLC17A8	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC17A8
GeneID	246213	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=246213
GeneTree	ENSGT00760000119079	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119079
HGNC	HGNC:20151	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20151
HOGENOM	HOG000230812	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230812&db=HOGENOM6
HOVERGEN	HBG008834	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG008834&db=HOVERGEN
InParanoid	Q8NDX2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8NDX2
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	246213	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=246213
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00604	http://www.genome.jp/dbget-bin/www_bget?H00604
KEGG_Gene	hsa:246213	http://www.genome.jp/dbget-bin/www_bget?hsa:246213
KEGG_Orthology	KO:K12302	http://www.genome.jp/dbget-bin/www_bget?KO:K12302
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
MIM	605583	http://www.ncbi.nlm.nih.gov/omim/605583
MIM	607557	http://www.ncbi.nlm.nih.gov/omim/607557
OMA	IWIMALM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IWIMALM
Orphanet	90635	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=90635
OrthoDB	EOG091G06DG	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G06DG
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:VGLU3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VGLU3_HUMAN
PSORT-B	swissprot:VGLU3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VGLU3_HUMAN
PSORT2	swissprot:VGLU3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VGLU3_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA223010	http://www.pharmgkb.org/do/serve?objId=PA223010&objCls=Gene
Phobius	swissprot:VGLU3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VGLU3_HUMAN
PhylomeDB	Q8NDX2	http://phylomedb.org/?seqid=Q8NDX2
ProteinModelPortal	Q8NDX2	http://www.proteinmodelportal.org/query/uniprot/Q8NDX2
PubMed	12151341	http://www.ncbi.nlm.nih.gov/pubmed/12151341
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18674745	http://www.ncbi.nlm.nih.gov/pubmed/18674745
Reactome	R-HSA-428643	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428643
RefSeq	NP_001138760	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001138760
RefSeq	NP_647480	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_647480
STRING	9606.ENSP00000316909	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000316909&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.14.32	http://www.tcdb.org/search/result.php?tc=2.A.1.14.32
UCSC	uc009ztx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc009ztx&org=rat
UniGene	Hs.116871	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.116871
UniProtKB	VGLU3_HUMAN	http://www.uniprot.org/uniprot/VGLU3_HUMAN
UniProtKB-AC	Q8NDX2	http://www.uniprot.org/uniprot/Q8NDX2
charge	swissprot:VGLU3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VGLU3_HUMAN
eggNOG	ENOG410XPWC	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPWC
eggNOG	KOG2532	http://eggnogapi.embl.de/nog_data/html/tree/KOG2532
epestfind	swissprot:VGLU3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VGLU3_HUMAN
garnier	swissprot:VGLU3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VGLU3_HUMAN
helixturnhelix	swissprot:VGLU3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VGLU3_HUMAN
hmoment	swissprot:VGLU3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VGLU3_HUMAN
iep	swissprot:VGLU3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VGLU3_HUMAN
inforesidue	swissprot:VGLU3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VGLU3_HUMAN
neXtProt	NX_Q8NDX2	http://www.nextprot.org/db/entry/NX_Q8NDX2
octanol	swissprot:VGLU3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VGLU3_HUMAN
pepcoil	swissprot:VGLU3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VGLU3_HUMAN
pepdigest	swissprot:VGLU3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VGLU3_HUMAN
pepinfo	swissprot:VGLU3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VGLU3_HUMAN
pepnet	swissprot:VGLU3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VGLU3_HUMAN
pepstats	swissprot:VGLU3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VGLU3_HUMAN
pepwheel	swissprot:VGLU3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VGLU3_HUMAN
pepwindow	swissprot:VGLU3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VGLU3_HUMAN
sigcleave	swissprot:VGLU3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VGLU3_HUMAN
## Database	ID	URL or Descriptions
# AltName	HDBP1_HUMAN	High density lipoprotein-binding protein 1
# DISEASE	HDBP1_HUMAN	Hyperlipoproteinemia 1D (HLPP1D) [MIM 615947]  An autosomal recessive disorder characterized by hyperlipoproteinemia, decreased plasma LPL levels in some patients, high plasma triglyceride levels, and refractory fasting chylomicronemia. {ECO 0000269|PubMed 19304573, ECO 0000269|PubMed 20026666, ECO 0000269|PubMed 21816778}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000622500	ENSP00000480053; ENSG00000277494
# FUNCTION	HDBP1_HUMAN	Plays a key role in the lipolytic processing of chylomicrons. Required for the transport of lipoprotein lipase LPL into the capillary lumen (By similarity). {ECO 0000250}. 
# GO_component	GO:0005622	intracellular; IEA:GOC.
# GO_component	GO:0009897	external side of plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0016323	basolateral plasma membrane; ISS:BHF-UCL.
# GO_component	GO:0016324	apical plasma membrane; ISS:BHF-UCL.
# GO_component	GO:0031362	anchored component of external side of plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0034364	high-density lipoprotein particle; IEA:UniProtKB-KW.
# GO_function	GO:0008035	high-density lipoprotein particle binding; IEA:Ensembl.
# GO_function	GO:0008289	lipid binding; IEA:UniProtKB-KW.
# GO_function	GO:0008320	protein transmembrane transporter activity; ISS:BHF-UCL.
# GO_function	GO:0035473	lipase binding; IPI:BHF-UCL.
# GO_function	GO:0035478	chylomicron binding; IDA:BHF-UCL.
# GO_function	GO:0071813	lipoprotein particle binding; IDA:UniProtKB.
# GO_process	GO:0006869	lipid transport; IEA:Ensembl.
# GO_process	GO:0006886	intracellular protein transport; ISS:BHF-UCL.
# GO_process	GO:0017038	protein import; ISS:BHF-UCL.
# GO_process	GO:0034394	protein localization to cell surface; ISS:BHF-UCL.
# GO_process	GO:0042632	cholesterol homeostasis; ISS:BHF-UCL.
# GO_process	GO:0045056	transcytosis; ISS:BHF-UCL.
# GO_process	GO:0050821	protein stabilization; ISS:BHF-UCL.
# GO_process	GO:0051006	positive regulation of lipoprotein lipase activity; IMP:BHF-UCL.
# GO_process	GO:0070328	triglyceride homeostasis; IMP:BHF-UCL.
# GO_process	GO:0071503	response to heparin; IMP:BHF-UCL.
# GO_process	GO:0090321	positive regulation of chylomicron remnant clearance; ISS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005622	intracellular
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008289	lipid binding
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0042592	homeostatic process
# Genevisible	Q8IV16	HS
# HGNC	HGNC:24945	GPIHBP1
# InterPro	IPR016054	LY6_UPA_recep-like
# MIM	612757	gene
# MIM	615947	phenotype
# Organism	HDBP1_HUMAN	Homo sapiens (Human)
# Orphanet	411	Hyperlipoproteinemia type 1
# Orphanet	70470	Hyperlipoproteinemia type 5
# POLYMORPHISM	HDBP1_HUMAN	The missense variant Arg-56 may be associated with severe hypertriglyceridemia and chylomicronemia. 
# PTM	HDBP1_HUMAN	Glycosylation of Asn-78 is critical for cell surface localization and the binding of chylomicrons and lipoprotein lipase. {ECO 0000250}. 
# Pfam	PF00021	UPAR_LY6
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-174800	Chylomicron-mediated lipid transport
# Reactome	R-HSA-975634	Retinoid metabolism and transport
# RecName	HDBP1_HUMAN	Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1
# RefSeq	NP_001288701	NM_001301772.1
# RefSeq	NP_835466	NM_178172.5
# SIMILARITY	Contains 1 UPAR/Ly6 domain. {ECO	0000305}.
# SUBCELLULAR LOCATION	HDBP1_HUMAN	Apical cell membrane {ECO 0000250|UniProtKB Q9D1N2}; Lipid-anchor, GPI-anchor {ECO 0000250|UniProtKB Q9D1N2}. Basolateral cell membrane {ECO 0000250|UniProtKB Q9D1N2}; Lipid-anchor, GPI-anchor {ECO 0000250|UniProtKB Q9D1N2}. Cell membrane {ECO 0000250|UniProtKB Q9D1N2}; Peripheral membrane protein {ECO 0000250|UniProtKB Q9D1N2}; Extracellular side {ECO 0000250|UniProtKB Q9D1N2}. 
# SUBUNIT	Binds with high affinity to high-density lipoprotein (HDL) (By similarity). Binds to lipoprotein lipase (LPL), chylomicrons and APOA5. {ECO	0000250}. 
# UCSC	uc033cbs	human
# eggNOG	ENOG410J46G	Eukaryota
# eggNOG	ENOG41116TR	LUCA
BLAST	swissprot:HDBP1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:HDBP1_HUMAN
COXPRESdb	338328	http://coxpresdb.jp/data/gene/338328.shtml
CleanEx	HS_GPIHBP1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GPIHBP1
CleanEx	HS_HBP1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_HBP1
DOI	10.1016/j.bbalip.2007.10.005	http://dx.doi.org/10.1016/j.bbalip.2007.10.005
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1161/ATVBAHA.109.186577	http://dx.doi.org/10.1161/ATVBAHA.109.186577
DOI	10.1186/1476-511X-6-23	http://dx.doi.org/10.1186/1476-511X-6-23
DOI	10.1194/jlr.M002717	http://dx.doi.org/10.1194/jlr.M002717
DOI	10.1194/jlr.R018689	http://dx.doi.org/10.1194/jlr.R018689
DOI	10.1210/jc.2011-1444	http://dx.doi.org/10.1210/jc.2011-1444
EMBL	AY245915	http://www.ebi.ac.uk/ena/data/view/AY245915
EMBL	BC035810	http://www.ebi.ac.uk/ena/data/view/BC035810
EMBL	BC063857	http://www.ebi.ac.uk/ena/data/view/BC063857
EMBL	CH471162	http://www.ebi.ac.uk/ena/data/view/CH471162
Ensembl	ENST00000622500	http://www.ensembl.org/id/ENST00000622500
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GO_component	GO:0009897	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009897
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0031362	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031362
GO_component	GO:0034364	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034364
GO_function	GO:0008035	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008035
GO_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GO_function	GO:0008320	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008320
GO_function	GO:0035473	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035473
GO_function	GO:0035478	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035478
GO_function	GO:0071813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071813
GO_process	GO:0006869	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006869
GO_process	GO:0006886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006886
GO_process	GO:0017038	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017038
GO_process	GO:0034394	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034394
GO_process	GO:0042632	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042632
GO_process	GO:0045056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045056
GO_process	GO:0050821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050821
GO_process	GO:0051006	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051006
GO_process	GO:0070328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070328
GO_process	GO:0071503	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071503
GO_process	GO:0090321	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090321
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GeneCards	GPIHBP1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GPIHBP1
GeneID	338328	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=338328
HGNC	HGNC:24945	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:24945
HOGENOM	HOG000112872	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000112872&db=HOGENOM6
HPA	HPA066302	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA066302
InParanoid	Q8IV16	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8IV16
IntAct	Q8IV16	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8IV16*
InterPro	IPR016054	http://www.ebi.ac.uk/interpro/entry/IPR016054
Jabion	338328	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=338328
KEGG_Gene	hsa:338328	http://www.genome.jp/dbget-bin/www_bget?hsa:338328
MIM	612757	http://www.ncbi.nlm.nih.gov/omim/612757
MIM	615947	http://www.ncbi.nlm.nih.gov/omim/615947
Orphanet	411	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=411
Orphanet	70470	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=70470
OrthoDB	EOG091G0UW5	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0UW5
PSORT	swissprot:HDBP1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:HDBP1_HUMAN
PSORT-B	swissprot:HDBP1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:HDBP1_HUMAN
PSORT2	swissprot:HDBP1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:HDBP1_HUMAN
Pfam	PF00021	http://pfam.xfam.org/family/PF00021
PharmGKB	PA162390135	http://www.pharmgkb.org/do/serve?objId=PA162390135&objCls=Gene
Phobius	swissprot:HDBP1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:HDBP1_HUMAN
PhylomeDB	Q8IV16	http://phylomedb.org/?seqid=Q8IV16
ProteinModelPortal	Q8IV16	http://www.proteinmodelportal.org/query/uniprot/Q8IV16
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17883852	http://www.ncbi.nlm.nih.gov/pubmed/17883852
PubMed	17997385	http://www.ncbi.nlm.nih.gov/pubmed/17997385
PubMed	19304573	http://www.ncbi.nlm.nih.gov/pubmed/19304573
PubMed	20026666	http://www.ncbi.nlm.nih.gov/pubmed/20026666
PubMed	21816778	http://www.ncbi.nlm.nih.gov/pubmed/21816778
PubMed	21844202	http://www.ncbi.nlm.nih.gov/pubmed/21844202
Reactome	R-HSA-174800	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-174800
Reactome	R-HSA-975634	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-975634
RefSeq	NP_001288701	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001288701
RefSeq	NP_835466	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_835466
STRING	9606.ENSP00000329266	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000329266&targetmode=cogs
UCSC	uc033cbs	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc033cbs&org=rat
UniGene	Hs.426410	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.426410
UniProtKB	HDBP1_HUMAN	http://www.uniprot.org/uniprot/HDBP1_HUMAN
UniProtKB-AC	Q8IV16	http://www.uniprot.org/uniprot/Q8IV16
charge	swissprot:HDBP1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:HDBP1_HUMAN
eggNOG	ENOG410J46G	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410J46G
eggNOG	ENOG41116TR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG41116TR
epestfind	swissprot:HDBP1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:HDBP1_HUMAN
garnier	swissprot:HDBP1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:HDBP1_HUMAN
helixturnhelix	swissprot:HDBP1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:HDBP1_HUMAN
hmoment	swissprot:HDBP1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:HDBP1_HUMAN
iep	swissprot:HDBP1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:HDBP1_HUMAN
inforesidue	swissprot:HDBP1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:HDBP1_HUMAN
neXtProt	NX_Q8IV16	http://www.nextprot.org/db/entry/NX_Q8IV16
octanol	swissprot:HDBP1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:HDBP1_HUMAN
pepcoil	swissprot:HDBP1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:HDBP1_HUMAN
pepdigest	swissprot:HDBP1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:HDBP1_HUMAN
pepinfo	swissprot:HDBP1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:HDBP1_HUMAN
pepnet	swissprot:HDBP1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:HDBP1_HUMAN
pepstats	swissprot:HDBP1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:HDBP1_HUMAN
pepwheel	swissprot:HDBP1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:HDBP1_HUMAN
pepwindow	swissprot:HDBP1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:HDBP1_HUMAN
sigcleave	swissprot:HDBP1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:HDBP1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNH7_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NS40-1; Sequence=Displayed; Name=2; IsoId=Q9NS40-2; Sequence=VSP_037116, VSP_037117, VSP_037118; Note=No experimental confirmation available.; 
# AltName	KCNH7_HUMAN	Ether-a-go-go-related gene potassium channel 3
# AltName	KCNH7_HUMAN	Voltage-gated potassium channel subunit Kv11.3
# CCDS	CCDS2219	-. [Q9NS40-1]
# CCDS	CCDS2220	-. [Q9NS40-2]
# ChiTaRS	KCNH7	human
# DOMAIN	KCNH7_HUMAN	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. 
# DrugBank	DB00308	Ibutilide
# DrugBank	DB00457	Prazosin
# DrugBank	DB00590	Doxazosin
# DrugBank	DB01110	Miconazole
# DrugBank	DB01162	Terazosin
# Ensembl	ENST00000328032	ENSP00000333781; ENSG00000184611. [Q9NS40-2]
# Ensembl	ENST00000332142	ENSP00000331727; ENSG00000184611. [Q9NS40-1]
# ExpressionAtlas	Q9NS40	baseline and differential
# FUNCTION	KCNH7_HUMAN	Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IBA:GO_Central.
# GO_process	GO:0042391	regulation of membrane potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# Gene3D	2.60.120.10	-; 1.
# Genevisible	Q9NS40	HS
# HGNC	HGNC:18863	KCNH7
# InterPro	IPR000014	PAS
# InterPro	IPR000595	cNMP-bd_dom
# InterPro	IPR003938	K_chnl_volt-dep_EAG/ELK/ERG
# InterPro	IPR003967	K_chnl_volt-dep_ERG
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR014710	RmlC-like_jellyroll
# InterPro	IPR018490	cNMP-bd-like
# KEGG_Brite	ko04040	Ion channels
# MIM	608169	gene
# Organism	KCNH7_HUMAN	Homo sapiens (Human)
# PRINTS	PR01463	EAGCHANLFMLY
# PRINTS	PR01470	ERGCHANNEL
# PROSITE	PS50042	CNMP_BINDING_3
# Pfam	PF00027	cNMP_binding
# Pfam	PF00520	Ion_trans
# Pfam	PF13426	PAS_9
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# RecName	KCNH7_HUMAN	Potassium voltage-gated channel subfamily H member 7
# RefSeq	NP_150375	NM_033272.3. [Q9NS40-1]
# RefSeq	NP_775185	NM_173162.2. [Q9NS40-2]
# SEQUENCE CAUTION	Sequence=AAD01946.1; Type=Frameshift; Positions=792, 795; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.3/KCNH7 sub-subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 PAC (PAS-associated C-terminal) domain. {ECO	0000305}. 
# SIMILARITY	Contains 1 PAS (PER-ARNT-SIM) domain. {ECO	0000305}. 
# SIMILARITY	Contains 1 cyclic nucleotide-binding domain. {ECO:0000255|PROSITE-ProRule	PRU00060}. 
# SMART	SM00100	cNMP
# SUBCELLULAR LOCATION	KCNH7_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH2/ERG1 and KCNH6/ERG2 (By similarity). {ECO	0000250}. 
# SUPFAM	SSF51206	SSF51206
# SUPFAM	SSF55785	SSF55785
# TIGRFAMs	TIGR00229	sensory_box
# TISSUE SPECIFICITY	Expressed in prolactin-secreting adenomas. {ECO:0000269|PubMed	12634931}. 
# UCSC	uc002uch	human. [Q9NS40-1]
# eggNOG	ENOG410XPSE	LUCA
# eggNOG	KOG0498	Eukaryota
BLAST	swissprot:KCNH7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNH7_HUMAN
COXPRESdb	90134	http://coxpresdb.jp/data/gene/90134.shtml
CleanEx	HS_KCNH7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNH7
DOI	10.1007/s00424-002-0980-0	http://dx.doi.org/10.1007/s00424-002-0980-0
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00308	http://www.drugbank.ca/drugs/DB00308
DrugBank	DB00457	http://www.drugbank.ca/drugs/DB00457
DrugBank	DB00590	http://www.drugbank.ca/drugs/DB00590
DrugBank	DB01110	http://www.drugbank.ca/drugs/DB01110
DrugBank	DB01162	http://www.drugbank.ca/drugs/DB01162
EMBL	AC007740	http://www.ebi.ac.uk/ena/data/view/AC007740
EMBL	AC010876	http://www.ebi.ac.uk/ena/data/view/AC010876
EMBL	AC104822	http://www.ebi.ac.uk/ena/data/view/AC104822
EMBL	AF032897	http://www.ebi.ac.uk/ena/data/view/AF032897
EMBL	BC035815	http://www.ebi.ac.uk/ena/data/view/BC035815
Ensembl	ENST00000328032	http://www.ensembl.org/id/ENST00000328032
Ensembl	ENST00000332142	http://www.ensembl.org/id/ENST00000332142
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	2.60.120.10	http://www.cathdb.info/version/latest/superfamily/2.60.120.10
GeneCards	KCNH7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNH7
GeneID	90134	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=90134
GeneTree	ENSGT00760000118772	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118772
HGNC	HGNC:18863	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18863
HOGENOM	HOG000230793	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230793&db=HOGENOM6
HOVERGEN	HBG052232	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052232&db=HOVERGEN
HPA	HPA018039	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA018039
InParanoid	Q9NS40	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NS40
IntAct	Q9NS40	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NS40*
InterPro	IPR000014	http://www.ebi.ac.uk/interpro/entry/IPR000014
InterPro	IPR000595	http://www.ebi.ac.uk/interpro/entry/IPR000595
InterPro	IPR003938	http://www.ebi.ac.uk/interpro/entry/IPR003938
InterPro	IPR003967	http://www.ebi.ac.uk/interpro/entry/IPR003967
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR014710	http://www.ebi.ac.uk/interpro/entry/IPR014710
InterPro	IPR018490	http://www.ebi.ac.uk/interpro/entry/IPR018490
Jabion	90134	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=90134
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:90134	http://www.genome.jp/dbget-bin/www_bget?hsa:90134
KEGG_Orthology	KO:K04910	http://www.genome.jp/dbget-bin/www_bget?KO:K04910
MIM	608169	http://www.ncbi.nlm.nih.gov/omim/608169
OMA	QMTTDIQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QMTTDIQ
OrthoDB	EOG091G024C	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G024C
PRINTS	PR01463	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01463
PRINTS	PR01470	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01470
PROSITE	PS50042	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50042
PSORT	swissprot:KCNH7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNH7_HUMAN
PSORT-B	swissprot:KCNH7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNH7_HUMAN
PSORT2	swissprot:KCNH7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNH7_HUMAN
Pfam	PF00027	http://pfam.xfam.org/family/PF00027
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF13426	http://pfam.xfam.org/family/PF13426
PharmGKB	PA38723	http://www.pharmgkb.org/do/serve?objId=PA38723&objCls=Gene
Phobius	swissprot:KCNH7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNH7_HUMAN
PhylomeDB	Q9NS40	http://phylomedb.org/?seqid=Q9NS40
ProteinModelPortal	Q9NS40	http://www.proteinmodelportal.org/query/uniprot/Q9NS40
PubMed	12634931	http://www.ncbi.nlm.nih.gov/pubmed/12634931
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
RefSeq	NP_150375	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_150375
RefSeq	NP_775185	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_775185
SMART	SM00100	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00100
SMR	Q9NS40	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9NS40
STRING	9606.ENSP00000331727	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000331727&targetmode=cogs
SUPFAM	SSF51206	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51206
SUPFAM	SSF55785	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55785
TIGRFAMs	TIGR00229	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00229
UCSC	uc002uch	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002uch&org=rat
UniGene	Hs.657413	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.657413
UniProtKB	KCNH7_HUMAN	http://www.uniprot.org/uniprot/KCNH7_HUMAN
UniProtKB-AC	Q9NS40	http://www.uniprot.org/uniprot/Q9NS40
charge	swissprot:KCNH7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNH7_HUMAN
eggNOG	ENOG410XPSE	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPSE
eggNOG	KOG0498	http://eggnogapi.embl.de/nog_data/html/tree/KOG0498
epestfind	swissprot:KCNH7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNH7_HUMAN
garnier	swissprot:KCNH7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNH7_HUMAN
helixturnhelix	swissprot:KCNH7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNH7_HUMAN
hmoment	swissprot:KCNH7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNH7_HUMAN
iep	swissprot:KCNH7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNH7_HUMAN
inforesidue	swissprot:KCNH7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNH7_HUMAN
neXtProt	NX_Q9NS40	http://www.nextprot.org/db/entry/NX_Q9NS40
octanol	swissprot:KCNH7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNH7_HUMAN
pepcoil	swissprot:KCNH7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNH7_HUMAN
pepdigest	swissprot:KCNH7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNH7_HUMAN
pepinfo	swissprot:KCNH7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNH7_HUMAN
pepnet	swissprot:KCNH7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNH7_HUMAN
pepstats	swissprot:KCNH7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNH7_HUMAN
pepwheel	swissprot:KCNH7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNH7_HUMAN
pepwindow	swissprot:KCNH7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNH7_HUMAN
sigcleave	swissprot:KCNH7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNH7_HUMAN
## Database	ID	URL or Descriptions
# AltName	SC6A7_HUMAN	Solute carrier family 6 member 7
# DrugBank	DB00172	L-Proline
# Ensembl	ENST00000230671	ENSP00000230671; ENSG00000011083
# ExpressionAtlas	Q99884	baseline and differential
# FUNCTION	SC6A7_HUMAN	Terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic terminals. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_function	GO:0015193	L-proline transmembrane transporter activity; IBA:GO_Central.
# GO_function	SC6A7_HUMAN	GO 0005298 proline sodium symporter activity; TAS Reactome.
# GO_function	SC6A7_HUMAN	GO 0005328 neurotransmitter sodium symporter activity; IEA InterPro.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0015824	proline transport; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q99884	HS
# HGNC	HGNC:11054	SLC6A7
# InterPro	IPR000175	Na/ntran_symport
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Brite	ko04040	 Ion channels
# MIM	606205	gene
# Organism	SC6A7_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11616	PTHR11616
# PRINTS	PR00176	NANEUSMPORT
# PROSITE	PS00610	NA_NEUROTRAN_SYMP_1
# PROSITE	PS00754	NA_NEUROTRAN_SYMP_2
# PROSITE	PS50267	NA_NEUROTRAN_SYMP_3
# Pfam	PF00209	SNF
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-442660	Na+/Cl- dependent neurotransmitter transporters
# Reactome	R-HSA-71288	Creatine metabolism
# RecName	SC6A7_HUMAN	Sodium-dependent proline transporter
# RefSeq	NP_055043	NM_014228.4
# SIMILARITY	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A7 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	SC6A7_HUMAN	Membrane; Multi-pass membrane protein. 
# TCDB	2.A.22.2.11:the neurotransmitter	sodium symporter (nss) family
# TISSUE SPECIFICITY	SC6A7_HUMAN	Brain. 
# UCSC	uc003lrr	human
# eggNOG	COG0733	LUCA
# eggNOG	KOG3659	Eukaryota
BLAST	swissprot:SC6A7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SC6A7_HUMAN
BioCyc	ZFISH:ENSG00000011083-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000011083-MONOMER
COXPRESdb	6534	http://coxpresdb.jp/data/gene/6534.shtml
CleanEx	HS_SLC6A7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC6A7
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00172	http://www.drugbank.ca/drugs/DB00172
EMBL	AC005895	http://www.ebi.ac.uk/ena/data/view/AC005895
EMBL	BC069631	http://www.ebi.ac.uk/ena/data/view/BC069631
EMBL	BC093785	http://www.ebi.ac.uk/ena/data/view/BC093785
EMBL	BC113425	http://www.ebi.ac.uk/ena/data/view/BC113425
EMBL	S80071	http://www.ebi.ac.uk/ena/data/view/S80071
Ensembl	ENST00000230671	http://www.ensembl.org/id/ENST00000230671
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0005298	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005298
GO_function	GO:0005328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005328
GO_function	GO:0015193	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015193
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0015824	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015824
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC6A7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC6A7
GeneID	6534	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6534
GeneTree	ENSGT00760000118857	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118857
H-InvDB	HIX0005311	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0005311
HGNC	HGNC:11054	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11054
HOGENOM	HOG000116406	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116406&db=HOGENOM6
HOVERGEN	HBG071421	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG071421&db=HOVERGEN
HPA	HPA028907	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA028907
InParanoid	Q99884	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q99884
InterPro	IPR000175	http://www.ebi.ac.uk/interpro/entry/IPR000175
Jabion	6534	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6534
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:6534	http://www.genome.jp/dbget-bin/www_bget?hsa:6534
KEGG_Orthology	KO:K05038	http://www.genome.jp/dbget-bin/www_bget?KO:K05038
MIM	606205	http://www.ncbi.nlm.nih.gov/omim/606205
PANTHER	PTHR11616	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11616
PRINTS	PR00176	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00176
PROSITE	PS00610	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00610
PROSITE	PS00754	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00754
PROSITE	PS50267	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50267
PSORT	swissprot:SC6A7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SC6A7_HUMAN
PSORT-B	swissprot:SC6A7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SC6A7_HUMAN
PSORT2	swissprot:SC6A7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SC6A7_HUMAN
Pfam	PF00209	http://pfam.xfam.org/family/PF00209
PharmGKB	PA35914	http://www.pharmgkb.org/do/serve?objId=PA35914&objCls=Gene
Phobius	swissprot:SC6A7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SC6A7_HUMAN
PhylomeDB	Q99884	http://phylomedb.org/?seqid=Q99884
ProteinModelPortal	Q99884	http://www.proteinmodelportal.org/query/uniprot/Q99884
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	7651355	http://www.ncbi.nlm.nih.gov/pubmed/7651355
Reactome	R-HSA-442660	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442660
Reactome	R-HSA-71288	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-71288
RefSeq	NP_055043	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055043
SMR	Q99884	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q99884
STRING	9606.ENSP00000230671	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000230671&targetmode=cogs
TCDB	2.A.22.2.11	http://www.tcdb.org/search/result.php?tc=2.A.22.2.11
UCSC	uc003lrr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003lrr&org=rat
UniGene	Hs.241597	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.241597
UniProtKB	SC6A7_HUMAN	http://www.uniprot.org/uniprot/SC6A7_HUMAN
UniProtKB-AC	Q99884	http://www.uniprot.org/uniprot/Q99884
charge	swissprot:SC6A7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SC6A7_HUMAN
eggNOG	COG0733	http://eggnogapi.embl.de/nog_data/html/tree/COG0733
eggNOG	KOG3659	http://eggnogapi.embl.de/nog_data/html/tree/KOG3659
epestfind	swissprot:SC6A7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SC6A7_HUMAN
garnier	swissprot:SC6A7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SC6A7_HUMAN
helixturnhelix	swissprot:SC6A7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SC6A7_HUMAN
hmoment	swissprot:SC6A7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SC6A7_HUMAN
iep	swissprot:SC6A7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SC6A7_HUMAN
inforesidue	swissprot:SC6A7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SC6A7_HUMAN
neXtProt	NX_Q99884	http://www.nextprot.org/db/entry/NX_Q99884
octanol	swissprot:SC6A7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SC6A7_HUMAN
pepcoil	swissprot:SC6A7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SC6A7_HUMAN
pepdigest	swissprot:SC6A7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SC6A7_HUMAN
pepinfo	swissprot:SC6A7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SC6A7_HUMAN
pepnet	swissprot:SC6A7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SC6A7_HUMAN
pepstats	swissprot:SC6A7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SC6A7_HUMAN
pepwheel	swissprot:SC6A7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SC6A7_HUMAN
pepwindow	swissprot:SC6A7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SC6A7_HUMAN
sigcleave	swissprot:SC6A7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SC6A7_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=4b; IsoId=O00305-1; Sequence=Displayed; Name=2; Synonyms=4a; IsoId=O00305-2; Sequence=VSP_000635; Note=Ref.2 (AAL14351) sequence is in conflict in position: 12	D->N. {ECO:0000305}; Name=3; IsoId=O00305-3; Sequence=VSP_043192; Note=No experimental confirmation available.; Name=4; Synonyms=4d; IsoId=O00305-4; Sequence=VSP_043193; Note=Unable to interact with the alpha-1 subunit.; 
# AltName	Calcium channel voltage-dependent subunit beta 4 {ECO	0000305}
# BioGrid	107239	8
# CCDS	CCDS46426	-. [O00305-1]
# CCDS	CCDS46427	-. [O00305-3]
# CCDS	CCDS46428	-. [O00305-2]
# CCDS	CCDS54409	-. [O00305-4]
# ChiTaRS	CACNB4	human
# DISEASE	CACB4_HUMAN	Epilepsy, idiopathic generalized 9 (EIG9) [MIM 607682]  A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. {ECO 0000269|PubMed 10762541}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# DISEASE	CACB4_HUMAN	Episodic ataxia 5 (EA5) [MIM 613855]  A disorder characterized by episodes of vertigo and ataxia that last for several hours. Interictal examination show spontaneous downbeat and gaze-evoked nystagmus, mild dysarthria and truncal ataxia. {ECO 0000269|PubMed 10762541}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CACB4_HUMAN	Juvenile myoclonic epilepsy 6 (EJM6) [MIM 607682]  A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# DrugBank	DB00393	Nimodipine
# DrugBank	DB00421	Spironolactone
# DrugBank	DB00661	Verapamil
# DrugBank	DB04855	Dronedarone
# Ensembl	ENST00000201943	ENSP00000201943; ENSG00000182389. [O00305-4]
# Ensembl	ENST00000534999	ENSP00000443893; ENSG00000182389. [O00305-2]
# Ensembl	ENST00000539935	ENSP00000438949; ENSG00000182389. [O00305-1]
# Ensembl	ENST00000638005	ENSP00000489677; ENSG00000182389. [O00305-3]
# ExpressionAtlas	O00305	baseline and differential
# FUNCTION	CACB4_HUMAN	The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. {ECO 0000269|PubMed 11880487}. 
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005891	voltage-gated calcium channel complex; IDA:UniProtKB.
# GO_component	GO:0009898	cytoplasmic side of plasma membrane; TAS:UniProtKB.
# GO_component	GO:0045202	synapse; IDA:UniProtKB.
# GO_function	GO:0005245	voltage-gated calcium channel activity; IEA:InterPro.
# GO_function	GO:0005262	calcium channel activity; TAS:Reactome.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007268	chemical synaptic transmission; IBA:GO_Central.
# GO_process	GO:0007528	neuromuscular junction development; IBA:GO_Central.
# GO_process	GO:0051899	membrane depolarization; TAS:Reactome.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:0070588	calcium ion transmembrane transport; IEA:GOC.
# GO_process	GO:1901385	regulation of voltage-gated calcium channel activity; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 1.
# Genevisible	O00305	HS
# HGNC	HGNC:1404	CACNB4
# INTERACTION	CACB4_HUMAN	P21579 SYT1; NbExp=2; IntAct=EBI-714855, EBI-524909; 
# IntAct	O00305	9
# InterPro	IPR000584	VDCC_L_bsu
# InterPro	IPR001452	SH3_domain
# InterPro	IPR008145	GK/Ca_channel_bsu
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00749	[Nervous system disease] Episodic ataxias
# KEGG_Disease	H00808	[Nervous system disease] Familial infantile myoclonic epilepsy (FIME)
# KEGG_Pathway	ko04010	MAPK signaling pathway
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05410	Hypertrophic cardiomyopathy (HCM)
# KEGG_Pathway	ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
# KEGG_Pathway	ko05414	Dilated cardiomyopathy
# MIM	601949	gene
# MIM	607682	phenotype
# MIM	613855	phenotype
# Organism	CACB4_HUMAN	Homo sapiens (Human)
# Orphanet	211067	Episodic ataxia type 5
# Orphanet	307	Juvenile myoclonic epilepsy
# PANTHER	PTHR11824	PTHR11824
# PDB	1VYV	X-ray; 3.00 A; A/B=254-408
# PDB	2D46	NMR; -; A=50-92
# PRINTS	PR01626	LCACHANNELB
# PROSITE	PS50002	SH3
# Pfam	PF00625	Guanylate_kin
# Pfam	PF12052	VGCC_beta4Aa_N
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-112308	Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
# Reactome	R-HSA-419037	NCAM1 interactions
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# Reactome	R-HSA-5576893	Phase 2 - plateau phase
# Reactome	R-HSA-5576894	Phase 1 - inactivation of fast Na+ channels
# RecName	Voltage-dependent L-type calcium channel subunit beta-4 {ECO	0000305}
# RefSeq	NP_000717	NM_000726.4. [O00305-1]
# RefSeq	NP_001005746	NM_001005746.3. [O00305-3]
# RefSeq	NP_001005747	NM_001005747.3. [O00305-2]
# RefSeq	NP_001139270	NM_001145798.2. [O00305-4]
# RefSeq	NP_001307651	NM_001320722.2
# SIMILARITY	Belongs to the calcium channel beta subunit family. {ECO	0000305}. 
# SIMILARITY	Contains 1 SH3 domain. {ECO:0000255|PROSITE- ProRule	PRU00192}.
# SMART	SM00072	GuKc
# SUBUNIT	CACB4_HUMAN	The L-type calcium channel is composed of four subunits  alpha-1, alpha-2, beta and gamma (PubMed 11880487). Interacts with FASLG (PubMed 19807924). Interacts with CBARP (By similarity). {ECO 0000250|UniProtKB Q8R0S4, ECO 0000269|PubMed 11880487, ECO 0000269|PubMed 19807924}. 
# SUPFAM	SSF50044	SSF50044
# SUPFAM	SSF52540	SSF52540
# TCDB	8.A.22.1	the ca(2+) channel auxiliary subunit types 1-4 (cca-) family
# TISSUE SPECIFICITY	CACB4_HUMAN	Expressed predominantly in the cerebellum and kidney. 
# UCSC	uc002txy	human. [O00305-1]
# eggNOG	ENOG410XRDI	LUCA
# eggNOG	KOG3812	Eukaryota
BLAST	swissprot:CACB4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CACB4_HUMAN
BioCyc	ZFISH:G66-33642-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33642-MONOMER
COXPRESdb	785	http://coxpresdb.jp/data/gene/785.shtml
CleanEx	HS_CACNB4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CACNB4
DOI	10.1006/geno.1998.5311	http://dx.doi.org/10.1006/geno.1998.5311
DOI	10.1007/s004390050482	http://dx.doi.org/10.1007/s004390050482
DOI	10.1016/j.bbrc.2007.06.112	http://dx.doi.org/10.1016/j.bbrc.2007.06.112
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1086/302909	http://dx.doi.org/10.1086/302909
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1110/ps.051894506	http://dx.doi.org/10.1110/ps.051894506
DOI	10.1186/1471-2172-10-53	http://dx.doi.org/10.1186/1471-2172-10-53
DrugBank	DB00393	http://www.drugbank.ca/drugs/DB00393
DrugBank	DB00421	http://www.drugbank.ca/drugs/DB00421
DrugBank	DB00661	http://www.drugbank.ca/drugs/DB00661
DrugBank	DB04855	http://www.drugbank.ca/drugs/DB04855
EMBL	AB302276	http://www.ebi.ac.uk/ena/data/view/AB302276
EMBL	AC068547	http://www.ebi.ac.uk/ena/data/view/AC068547
EMBL	AC079790	http://www.ebi.ac.uk/ena/data/view/AC079790
EMBL	AC097448	http://www.ebi.ac.uk/ena/data/view/AC097448
EMBL	AF038852	http://www.ebi.ac.uk/ena/data/view/AF038852
EMBL	AK290049	http://www.ebi.ac.uk/ena/data/view/AK290049
EMBL	AK294398	http://www.ebi.ac.uk/ena/data/view/AK294398
EMBL	AK316045	http://www.ebi.ac.uk/ena/data/view/AK316045
EMBL	AY054985	http://www.ebi.ac.uk/ena/data/view/AY054985
EMBL	BC075049	http://www.ebi.ac.uk/ena/data/view/BC075049
EMBL	CH471058	http://www.ebi.ac.uk/ena/data/view/CH471058
EMBL	U95020	http://www.ebi.ac.uk/ena/data/view/U95020
Ensembl	ENST00000201943	http://www.ensembl.org/id/ENST00000201943
Ensembl	ENST00000534999	http://www.ensembl.org/id/ENST00000534999
Ensembl	ENST00000539935	http://www.ensembl.org/id/ENST00000539935
Ensembl	ENST00000638005	http://www.ensembl.org/id/ENST00000638005
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005891
GO_component	GO:0009898	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009898
GO_component	GO:0045202	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045202
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007528	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007528
GO_process	GO:0051899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051899
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:1901385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901385
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	CACNB4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CACNB4
GeneID	785	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=785
GeneTree	ENSGT00390000002740	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002740
HGNC	HGNC:1404	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1404
HOGENOM	HOG000230979	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230979&db=HOGENOM6
HOVERGEN	HBG050765	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050765&db=HOVERGEN
HPA	HPA015601	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA015601
InParanoid	O00305	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O00305
IntAct	O00305	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O00305*
InterPro	IPR000584	http://www.ebi.ac.uk/interpro/entry/IPR000584
InterPro	IPR001452	http://www.ebi.ac.uk/interpro/entry/IPR001452
InterPro	IPR008145	http://www.ebi.ac.uk/interpro/entry/IPR008145
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	785	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=785
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00749	http://www.genome.jp/dbget-bin/www_bget?H00749
KEGG_Disease	H00808	http://www.genome.jp/dbget-bin/www_bget?H00808
KEGG_Gene	hsa:785	http://www.genome.jp/dbget-bin/www_bget?hsa:785
KEGG_Orthology	KO:K04865	http://www.genome.jp/dbget-bin/www_bget?KO:K04865
KEGG_Pathway	ko04010	http://www.genome.jp/kegg-bin/show_pathway?ko04010
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05410	http://www.genome.jp/kegg-bin/show_pathway?ko05410
KEGG_Pathway	ko05412	http://www.genome.jp/kegg-bin/show_pathway?ko05412
KEGG_Pathway	ko05414	http://www.genome.jp/kegg-bin/show_pathway?ko05414
MIM	601949	http://www.ncbi.nlm.nih.gov/omim/601949
MIM	607682	http://www.ncbi.nlm.nih.gov/omim/607682
MIM	613855	http://www.ncbi.nlm.nih.gov/omim/613855
MINT	MINT-1418672	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1418672
OMA	SYQDSYK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SYQDSYK
Orphanet	211067	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=211067
Orphanet	307	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=307
OrthoDB	EOG091G09C1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G09C1
PANTHER	PTHR11824	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11824
PDB	1VYV	http://www.ebi.ac.uk/pdbe-srv/view/entry/1VYV
PDB	2D46	http://www.ebi.ac.uk/pdbe-srv/view/entry/2D46
PDBsum	1VYV	http://www.ebi.ac.uk/pdbsum/1VYV
PDBsum	2D46	http://www.ebi.ac.uk/pdbsum/2D46
PRINTS	PR01626	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01626
PROSITE	PS50002	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50002
PSORT	swissprot:CACB4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CACB4_HUMAN
PSORT-B	swissprot:CACB4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CACB4_HUMAN
PSORT2	swissprot:CACB4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CACB4_HUMAN
Pfam	PF00625	http://pfam.xfam.org/family/PF00625
Pfam	PF12052	http://pfam.xfam.org/family/PF12052
PharmGKB	PA26014	http://www.pharmgkb.org/do/serve?objId=PA26014&objCls=Gene
Phobius	swissprot:CACB4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CACB4_HUMAN
PhylomeDB	O00305	http://phylomedb.org/?seqid=O00305
ProteinModelPortal	O00305	http://www.proteinmodelportal.org/query/uniprot/O00305
PubMed	10762541	http://www.ncbi.nlm.nih.gov/pubmed/10762541
PubMed	11880487	http://www.ncbi.nlm.nih.gov/pubmed/11880487
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	16385006	http://www.ncbi.nlm.nih.gov/pubmed/16385006
PubMed	17618603	http://www.ncbi.nlm.nih.gov/pubmed/17618603
PubMed	19807924	http://www.ncbi.nlm.nih.gov/pubmed/19807924
PubMed	9254841	http://www.ncbi.nlm.nih.gov/pubmed/9254841
PubMed	9628818	http://www.ncbi.nlm.nih.gov/pubmed/9628818
Reactome	R-HSA-112308	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112308
Reactome	R-HSA-419037	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-419037
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
Reactome	R-HSA-5576893	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576893
Reactome	R-HSA-5576894	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576894
RefSeq	NP_000717	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000717
RefSeq	NP_001005746	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001005746
RefSeq	NP_001005747	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001005747
RefSeq	NP_001139270	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001139270
RefSeq	NP_001307651	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001307651
SMART	SM00072	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00072
SMR	O00305	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O00305
STRING	9606.ENSP00000438949	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000438949&targetmode=cogs
SUPFAM	SSF50044	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50044
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TCDB	8.A.22.1	http://www.tcdb.org/search/result.php?tc=8.A.22.1
UCSC	uc002txy	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002txy&org=rat
UniGene	Hs.120725	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.120725
UniProtKB	CACB4_HUMAN	http://www.uniprot.org/uniprot/CACB4_HUMAN
UniProtKB-AC	O00305	http://www.uniprot.org/uniprot/O00305
charge	swissprot:CACB4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CACB4_HUMAN
eggNOG	ENOG410XRDI	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRDI
eggNOG	KOG3812	http://eggnogapi.embl.de/nog_data/html/tree/KOG3812
epestfind	swissprot:CACB4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CACB4_HUMAN
garnier	swissprot:CACB4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CACB4_HUMAN
helixturnhelix	swissprot:CACB4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CACB4_HUMAN
hmoment	swissprot:CACB4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CACB4_HUMAN
iep	swissprot:CACB4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CACB4_HUMAN
inforesidue	swissprot:CACB4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CACB4_HUMAN
neXtProt	NX_O00305	http://www.nextprot.org/db/entry/NX_O00305
octanol	swissprot:CACB4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CACB4_HUMAN
pepcoil	swissprot:CACB4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CACB4_HUMAN
pepdigest	swissprot:CACB4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CACB4_HUMAN
pepinfo	swissprot:CACB4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CACB4_HUMAN
pepnet	swissprot:CACB4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CACB4_HUMAN
pepstats	swissprot:CACB4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CACB4_HUMAN
pepwheel	swissprot:CACB4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CACB4_HUMAN
pepwindow	swissprot:CACB4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CACB4_HUMAN
sigcleave	swissprot:CACB4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CACB4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TM175_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BSA9-1; Sequence=Displayed; Name=2; IsoId=Q9BSA9-2; Sequence=VSP_024213; 
# AltName	Transmembrane protein 175 {ECO:0000312|HGNC	HGNC:28709}
# CCDS	CCDS3341	-. [Q9BSA9-1]
# CCDS	CCDS75088	-. [Q9BSA9-2]
# ChiTaRS	TMEM175	human
# DOMAIN	TM175_HUMAN	Probably forms a two-repeat structure, with each repeat containing 6 transmembrane regions. The first transmembrane region of each repeat (named IS1 and IIS1, repectively), which contain the invariant FSD motif probably form the ion filter. Negatively charged residues (Asp/Glu) within the helices may interact with potassium ions to achieve the potassium selectivity. {ECO 0000305|PubMed 26317472}. 
# Ensembl	ENST00000264771	ENSP00000264771; ENSG00000127419. [Q9BSA9-1]
# Ensembl	ENST00000515740	ENSP00000427039; ENSG00000127419. [Q9BSA9-2]
# Ensembl	ENST00000622959	ENSP00000485461; ENSG00000127419. [Q9BSA9-2]
# ExpressionAtlas	Q9BSA9	baseline and differential
# FUNCTION	TM175_HUMAN	Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion. Constitutes the major lysosomal potassium channel. {ECO 0000269|PubMed 26317472}. 
# GO_component	GO:0005764	lysosome; IDA:UniProtKB.
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005768	endosome; IDA:UniProtKB.
# GO_component	GO:0010008	endosome membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0022841	potassium ion leak channel activity; IDA:UniProtKB.
# GO_process	GO:0035751	regulation of lysosomal lumen pH; IEA:Ensembl.
# GO_process	GO:0071805	potassium ion transmembrane transport; IDA:UniProtKB.
# GO_process	GO:0090385	phagosome-lysosome fusion; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005764	lysosome
# GOslim_component	GO:0005768	endosome
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# GOslim_process	GO:0061024	membrane organization
# Genevisible	Q9BSA9	HS
# HGNC	HGNC:28709	TMEM175
# IntAct	Q9BSA9	4
# InterPro	IPR010617	TMEM175
# MIM	616660	gene
# Organism	TM175_HUMAN	Homo sapiens (Human)
# Pfam	PF06736	DUF1211; 2
# Proteomes	UP000005640	Chromosome 4
# RecName	Endosomal/lysomomal potassium channel TMEM175 {ECO	0000305}
# RefSeq	NP_001284355	NM_001297426.1. [Q9BSA9-2]
# RefSeq	NP_001284356	NM_001297427.1. [Q9BSA9-2]
# RefSeq	NP_001284357	NM_001297428.1. [Q9BSA9-2]
# RefSeq	NP_115702	NM_032326.3. [Q9BSA9-1]
# RefSeq	XP_005272361	XM_005272304.1. [Q9BSA9-2]
# RefSeq	XP_016864190	XM_017008701.1. [Q9BSA9-1]
# RefSeq	XP_016864194	XM_017008705.1. [Q9BSA9-2]
# SIMILARITY	Belongs to the TMEM175 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	TM175_HUMAN	Endosome membrane {ECO 0000269|PubMed 26317472}; Multi-pass membrane protein {ECO 0000255}. Lysosome membrane {ECO 0000269|PubMed 26317472}; Multi-pass membrane protein {ECO 0000255}. 
# TCDB	1.A.78.1	the k+-selective channel in endosomes and lysosomes (kel) family
# TISSUE SPECIFICITY	Widely expressed. {ECO:0000269|PubMed	26317472}. 
# UCSC	uc003gbq	human. [Q9BSA9-1]
# eggNOG	ENOG410IIWE	Eukaryota
# eggNOG	ENOG410ZP3B	LUCA
BLAST	swissprot:TM175_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TM175_HUMAN
BioCyc	ZFISH:ENSG00000127419-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000127419-MONOMER
COXPRESdb	84286	http://coxpresdb.jp/data/gene/84286.shtml
CleanEx	HS_TMEM175	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TMEM175
DOI	10.1016/j.cell.2015.08.002	http://dx.doi.org/10.1016/j.cell.2015.08.002
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AL834199	http://www.ebi.ac.uk/ena/data/view/AL834199
EMBL	BC005158	http://www.ebi.ac.uk/ena/data/view/BC005158
EMBL	CH471131	http://www.ebi.ac.uk/ena/data/view/CH471131
EMBL	CH471131	http://www.ebi.ac.uk/ena/data/view/CH471131
Ensembl	ENST00000264771	http://www.ensembl.org/id/ENST00000264771
Ensembl	ENST00000515740	http://www.ensembl.org/id/ENST00000515740
Ensembl	ENST00000622959	http://www.ensembl.org/id/ENST00000622959
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GO_component	GO:0010008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010008
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0022841	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022841
GO_process	GO:0035751	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035751
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GO_process	GO:0090385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090385
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
GeneCards	TMEM175	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TMEM175
GeneID	84286	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84286
GeneTree	ENSGT00390000015667	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000015667
H-InvDB	HIX0004008	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0004008
HGNC	HGNC:28709	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:28709
HOGENOM	HOG000154616	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000154616&db=HOGENOM6
HOVERGEN	HBG059914	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG059914&db=HOVERGEN
HPA	HPA057160	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA057160
InParanoid	Q9BSA9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9BSA9
IntAct	Q9BSA9	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9BSA9*
InterPro	IPR010617	http://www.ebi.ac.uk/interpro/entry/IPR010617
Jabion	84286	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=84286
KEGG_Gene	hsa:84286	http://www.genome.jp/dbget-bin/www_bget?hsa:84286
MIM	616660	http://www.ncbi.nlm.nih.gov/omim/616660
OMA	ACMMLIT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ACMMLIT
OrthoDB	EOG091G05QO	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05QO
PSORT	swissprot:TM175_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TM175_HUMAN
PSORT-B	swissprot:TM175_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TM175_HUMAN
PSORT2	swissprot:TM175_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TM175_HUMAN
Pfam	PF06736	http://pfam.xfam.org/family/PF06736
PharmGKB	PA162405946	http://www.pharmgkb.org/do/serve?objId=PA162405946&objCls=Gene
Phobius	swissprot:TM175_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TM175_HUMAN
PhylomeDB	Q9BSA9	http://phylomedb.org/?seqid=Q9BSA9
ProteinModelPortal	Q9BSA9	http://www.proteinmodelportal.org/query/uniprot/Q9BSA9
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	26317472	http://www.ncbi.nlm.nih.gov/pubmed/26317472
RefSeq	NP_001284355	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001284355
RefSeq	NP_001284356	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001284356
RefSeq	NP_001284357	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001284357
RefSeq	NP_115702	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_115702
RefSeq	XP_005272361	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005272361
RefSeq	XP_016864190	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016864190
RefSeq	XP_016864194	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016864194
STRING	9606.ENSP00000264771	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000264771&targetmode=cogs
TCDB	1.A.78.1	http://www.tcdb.org/search/result.php?tc=1.A.78.1
UCSC	uc003gbq	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003gbq&org=rat
UniGene	Hs.478936	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.478936
UniProtKB	TM175_HUMAN	http://www.uniprot.org/uniprot/TM175_HUMAN
UniProtKB-AC	Q9BSA9	http://www.uniprot.org/uniprot/Q9BSA9
charge	swissprot:TM175_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TM175_HUMAN
eggNOG	ENOG410IIWE	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IIWE
eggNOG	ENOG410ZP3B	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZP3B
epestfind	swissprot:TM175_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TM175_HUMAN
garnier	swissprot:TM175_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TM175_HUMAN
helixturnhelix	swissprot:TM175_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TM175_HUMAN
hmoment	swissprot:TM175_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TM175_HUMAN
iep	swissprot:TM175_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TM175_HUMAN
inforesidue	swissprot:TM175_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TM175_HUMAN
neXtProt	NX_Q9BSA9	http://www.nextprot.org/db/entry/NX_Q9BSA9
octanol	swissprot:TM175_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TM175_HUMAN
pepcoil	swissprot:TM175_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TM175_HUMAN
pepdigest	swissprot:TM175_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TM175_HUMAN
pepinfo	swissprot:TM175_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TM175_HUMAN
pepnet	swissprot:TM175_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TM175_HUMAN
pepstats	swissprot:TM175_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TM175_HUMAN
pepwheel	swissprot:TM175_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TM175_HUMAN
pepwindow	swissprot:TM175_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TM175_HUMAN
sigcleave	swissprot:TM175_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TM175_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CEAM1_HUMAN	Event=Alternative splicing; Named isoforms=11; Name=1; Synonyms=BGPa, CEACAM1-4L {ECO 0000303|PubMed 11501563}, TM1-CEA; IsoId=P13688-1; Sequence=Displayed; Name=2; Synonyms=BGPg, CEACAM1-4C1 {ECO 0000303|PubMed 11501563}; IsoId=P13688-2; Sequence=VSP_002482, VSP_002483; Name=3; Synonyms=BGPh, CEACAM1-3 {ECO 0000303|PubMed 11501563}; IsoId=P13688-3; Sequence=VSP_002478, VSP_002479; Name=4; Synonyms=BGPi, CEACAM1-3C2 {ECO 0000303|PubMed 11501563}; IsoId=P13688-4; Sequence=VSP_002480, VSP_002481; Name=5; Synonyms=BGPy, CEACAM1-3AL {ECO 0000303|PubMed 11501563}; IsoId=P13688-5; Sequence=VSP_009227; Note=Ref.6 (AAA57143) sequence is in conflict in position  323 N->L. Ref.6 (AAA57143) sequence is in conflict in position  337 Q->E. Ref.5 (BAA02063) sequence is in conflict in position  329 R->G. {ECO 0000305}; Name=6; Synonyms=BGPb, CEACAM1-3L {ECO 0000303|PubMed 11501563}, TM2-CEA; IsoId=P13688-6; Sequence=VSP_010938; Name=7; Synonyms=BGPx, CEACAM1-1L {ECO 0000303|PubMed 11501563}; IsoId=P13688-7; Sequence=VSP_012222; Name=8; Synonyms=BGPc, CEACAM1-4S {ECO 0000303|PubMed 11501563}, TM3-CEA; IsoId=P13688-8; Sequence=VSP_040572, VSP_040574; Note=Pseudophosphorylated double mutant Thr-457->Asp and Ser-459->Asp. The single mutant Ser-459->Asp mutant highly binds with ANXA2. {ECO 0000269|PubMed 14522961}; Name=9; Synonyms=BGPz, CEACAM1-3AS; IsoId=P13688-9; Sequence=VSP_040571, VSP_040572, VSP_040574; Name=10; IsoId=P13688-10; Sequence=VSP_040573, VSP_040575; Note=No experimental confirmation available.; Name=11; Synonyms=BGPd, CEACAM1-3S; IsoId=P13688-11; Sequence=VSP_010938, VSP_040572, VSP_040574; 
# AltName	Biliary glycoprotein 1 {ECO:0000303|PubMed	7628460}
# AltName	CEAM1_HUMAN	CD66a
# BioGrid	107103	12
# CCDS	CCDS12609	-. [P13688-1]
# CCDS	CCDS46089	-. [P13688-8]
# CCDS	CCDS54272	-. [P13688-11]
# CCDS	CCDS54273	-. [P13688-6]
# CCDS	CCDS54274	-. [P13688-5]
# DOMAIN	CEAM1_HUMAN	Ig-like V-type domain mediates trans-homophilic cell adhesion through homodimerization and this active process is regulated by tyrosine kinase, PTPN11 AND PTPN6. Ig-like C2-type and/or cytoplasmic domains mediate cis-dimer/oligomer. {ECO 0000250|UniProtKB P16573}. 
# DrugBank	DB00113	Arcitumomab
# Ensembl	ENST00000161559	ENSP00000161559; ENSG00000079385. [P13688-1]
# Ensembl	ENST00000352591	ENSP00000244291; ENSG00000079385. [P13688-6]
# Ensembl	ENST00000358394	ENSP00000351165; ENSG00000079385. [P13688-5]
# Ensembl	ENST00000403444	ENSP00000384709; ENSG00000079385. [P13688-8]
# Ensembl	ENST00000403461	ENSP00000384083; ENSG00000079385. [P13688-11]
# Ensembl	ENST00000599389	ENSP00000471918; ENSG00000079385. [P13688-9]
# ExpressionAtlas	P13688	baseline and differential
# FUNCTION	CEAM1_HUMAN	Isoform 1  Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Plays a role as coinhibitory receptor in immune response, insulin action and functions also as an activator during angiogenesis (PubMed 18424730, PubMed 23696226, PubMed 25363763). Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils (PubMed 18424730, PubMed 23696226). Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70 (PubMed 18424730). Also inhibits T cell proliferation and cytokine production through inhibition of JNK cascade and plays a crucial role in regulating autoimmunity and anti-tumor immunity by inhibiting T cell through its interaction with HAVCR2 (PubMed 25363763). Upon natural killer (NK) cells activation, inhibit KLRK1-mediated cytolysis of CEACAM1-bearing tumor cells by trans-homophilic interactions with CEACAM1 on the target cell and lead to cis-interaction between CEACAM1 and KLRK1, allowing PTPN6 recruitment and then VAV1 dephosphorylation (PubMed 23696226). Upon neutrophils activation negatively regulates IL1B production by recruiting PTPN6 to a SYK-TLR4- CEACAM1 complex, that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome. Downregulates neutrophil production by acting as a coinhibitory receptor for CSF3R by downregulating the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (By similarity). Also regulates insulin action by promoting INS clearance and regulating lipogenesis in liver through regulating insulin signaling (By similarity). Upon INS stimulation, undergoes phosphorylation by INSR leading to INS clearance by increasing receptor-mediated insulin endocytosis. This inernalization promotes interaction with FASN leading to receptor-mediated insulin degradation and to reduction of FASN activity leading to negative regulation of fatty acid synthesis. INSR-mediated phosphorylation also provokes a down-regulation of cell proliferation through SHC1 interaction resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 and phosphatidylinositol 3-kinase pathways (By similarity). Functions as activator in angiogenesis by promoting blood vessel remodeling through endothelial cell differentiation and migration and in arteriogenesis by increasing the number of collateral arteries and collateral vessel calibers after ischemia. Also regulates vascular permeability through the VEGFR2 signaling pathway resulting in control of nitric oxide production (By similarity). Downregulates cell growth in response to EGF through its interaction with SHC1 that mediates interaction with EGFR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (By similarity). Negatively regulates platelet aggregation by decreasing platelet adhesion on type I collagen through the GPVI-FcRgamma complex (By similarity). Inhibits cell migration and cell scattering through interaction with FLNA; interfers with the interaction of FLNA with RALA (PubMed 16291724). Mediates bile acid transport activity in a phosphorylation dependent manner (By similarity). Negatively regulates osteoclastogenesis (By similarity). {ECO 0000250|UniProtKB P16573, ECO 0000250|UniProtKB P31809, ECO 0000269|PubMed 16291724, ECO 0000269|PubMed 18424730, ECO 0000269|PubMed 23696226, ECO 0000269|PubMed 25363763}. 
# FUNCTION	CEAM1_HUMAN	Isoform 8  Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Promotes populations of T cells regulating IgA production and secretion associated with control of the commensal microbiota and resistance to enteropathogens (By similarity). {ECO 0000250|UniProtKB P16573, ECO 0000250|UniProtKB P31809}. 
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; NAS:UniProtKB.
# GO_component	GO:0005911	cell-cell junction; IDA:UniProtKB.
# GO_component	GO:0005912	adherens junction; ISS:UniProtKB.
# GO_component	GO:0009925	basal plasma membrane; ISS:UniProtKB.
# GO_component	GO:0009986	cell surface; IDA:UniProtKB.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0016021	integral component of membrane; IDA:MGI.
# GO_component	GO:0016324	apical plasma membrane; ISS:UniProtKB.
# GO_component	GO:0016328	lateral plasma membrane; ISS:UniProtKB.
# GO_component	GO:0030054	cell junction; IDA:UniProtKB.
# GO_component	GO:0030658	transport vesicle membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0003779	actin binding; IPI:UniProtKB.
# GO_function	GO:0015125	bile acid transmembrane transporter activity; ISS:UniProtKB.
# GO_function	GO:0019900	kinase binding; IPI:UniProtKB.
# GO_function	GO:0019903	protein phosphatase binding; IPI:UniProtKB.
# GO_function	GO:0031005	filamin binding; IPI:UniProtKB.
# GO_function	GO:0042803	protein homodimerization activity; IMP:UniProtKB.
# GO_function	GO:0046983	protein dimerization activity; ISS:UniProtKB.
# GO_function	GO:1990782	protein tyrosine kinase binding; IPI:UniProtKB.
# GO_process	GO:0001525	angiogenesis; NAS:UniProtKB.
# GO_process	GO:0001558	regulation of cell growth; ISS:UniProtKB.
# GO_process	GO:0001568	blood vessel development; ISS:UniProtKB.
# GO_process	GO:0001915	negative regulation of T cell mediated cytotoxicity; IDA:UniProtKB.
# GO_process	GO:0002859	negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; IMP:UniProtKB.
# GO_process	GO:0006469	negative regulation of protein kinase activity; ISS:UniProtKB.
# GO_process	GO:0007155	cell adhesion; ISS:UniProtKB.
# GO_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules; ISS:UniProtKB.
# GO_process	GO:0007229	integrin-mediated signaling pathway; NAS:UniProtKB.
# GO_process	GO:0010594	regulation of endothelial cell migration; ISS:UniProtKB.
# GO_process	GO:0014066	regulation of phosphatidylinositol 3-kinase signaling; ISS:UniProtKB.
# GO_process	GO:0015721	bile acid and bile salt transport; ISS:UniProtKB.
# GO_process	GO:0016477	cell migration; NAS:UniProtKB.
# GO_process	GO:0030334	regulation of cell migration; IDA:UniProtKB.
# GO_process	GO:0030853	negative regulation of granulocyte differentiation; ISS:UniProtKB.
# GO_process	GO:0032692	negative regulation of interleukin-1 production; ISS:UniProtKB.
# GO_process	GO:0032869	cellular response to insulin stimulus; ISS:UniProtKB.
# GO_process	GO:0035726	common myeloid progenitor cell proliferation; ISS:UniProtKB.
# GO_process	GO:0038016	insulin receptor internalization; ISS:UniProtKB.
# GO_process	GO:0038158	granulocyte colony-stimulating factor signaling pathway; ISS:UniProtKB.
# GO_process	GO:0042058	regulation of epidermal growth factor receptor signaling pathway; ISS:UniProtKB.
# GO_process	GO:0043116	negative regulation of vascular permeability; ISS:UniProtKB.
# GO_process	GO:0043318	negative regulation of cytotoxic T cell degranulation; IDA:UniProtKB.
# GO_process	GO:0044319	wound healing, spreading of cells; IDA:UniProtKB.
# GO_process	GO:0045601	regulation of endothelial cell differentiation; ISS:UniProtKB.
# GO_process	GO:0045717	negative regulation of fatty acid biosynthetic process; ISS:UniProtKB.
# GO_process	GO:0050860	negative regulation of T cell receptor signaling pathway; IDA:UniProtKB.
# GO_process	GO:0050900	leukocyte migration; TAS:Reactome.
# GO_process	GO:0051055	negative regulation of lipid biosynthetic process; ISS:UniProtKB.
# GO_process	GO:0060312	regulation of blood vessel remodeling; ISS:UniProtKB.
# GO_process	GO:0070372	regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
# GO_process	GO:0090331	negative regulation of platelet aggregation; ISS:UniProtKB.
# GO_process	GO:0098609	cell-cell adhesion; ISS:UniProtKB.
# GO_process	GO:1901143	insulin catabolic process; ISS:UniProtKB.
# GO_process	GO:1903385	regulation of homophilic cell adhesion; ISS:UniProtKB.
# GO_process	GO:1903670	regulation of sprouting angiogenesis; ISS:UniProtKB.
# GO_process	GO:2000346	negative regulation of hepatocyte proliferation; ISS:UniProtKB.
# GO_process	GO:2001214	positive regulation of vasculogenesis; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008092	cytoskeletal protein binding
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0003013	circulatory system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007155	cell adhesion
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0008283	cell proliferation
# GOslim_process	GO:0009056	catabolic process
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0048646	anatomical structure formation involved in morphogenesis
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0048870	cell motility
# Gene3D	2.60.40.10	-; 4.
# Genevisible	P13688	HS
# HGNC	HGNC:1814	CEACAM1
# INDUCTION	Induced in primary T cells by activation with IL-2. {ECO:0000269|PubMed	18424730}. 
# INTERACTION	CEAM1_HUMAN	Q16568 CARTPT; NbExp=3; IntAct=EBI-4314481, EBI-4314526; P40199 CEACAM6; NbExp=2; IntAct=EBI-4314481, EBI-4314501; Q8GH87 uspa1 (xeno); NbExp=12; IntAct=EBI-4314481, EBI-7936357; 
# IntAct	P13688	6
# InterPro	IPR003598	Ig_sub2
# InterPro	IPR003599	Ig_sub
# InterPro	IPR007110	Ig-like_dom
# InterPro	IPR013106	Ig_V-set
# InterPro	IPR013151	Immunoglobulin
# InterPro	IPR013783	Ig-like_fold
# KEGG_Brite	ko04090	 Cellular antigens
# KEGG_Brite	ko04516	Cell adhesion molecules and their ligands
# MIM	109770	gene
# Organism	CEAM1_HUMAN	Homo sapiens (Human)
# PDB	2GK2	X-ray; 2.20 A; A/B=34-141
# PDB	4QXW	X-ray; 2.04 A; A/B=35-141
# PDB	4WHD	X-ray; 2.50 A; A/B=34-141
# PDB	5DZL	X-ray; 3.40 A; A/B/C/D=35-141
# PIR	A32164	A32164
# PIR	B48078	B48078
# PIR	JH0394	JH0394
# PIR	JH0395	JH0395
# PIR	JH0396	JH0396
# PROSITE	PS50835	IG_LIKE; 3
# PTM	CEAM1_HUMAN	Isoform 1  Phosphorylated on serine and tyrosine (By similarity). Isoform 1 is phosphorylated on tyrosine by Src family kinases like SRC and LCK and by receptor like CSF3R, EGFR and INSR upon stimulation (PubMed 15467833, PubMed 18424730, PubMed 7478590). Phosphorylated at Ser-508; mediates activity. Phosphorylated at Tyr-493; regulates activity (By similarity). Phosphorylated at Tyr-493 by EGFR and INSR upon stimulation; this phosphorylation is Ser-508-phosphorylation-dependent; mediates cellular internalization; increases interaction with downstream proteins like SHC1 and FASN (By similarity). Phosphorylated at Tyr-493 and Tyr-520 by LCK; mediates PTPN6 association and is regulated by homophilic ligation of CEACAM1 in the absence of T cell activation (PubMed 18424730). Phosphorylated at Tyr-520; mediates interaction with PTPN11 (By similarity). {ECO 0000250|UniProtKB P16573, ECO 0000250|UniProtKB P31809, ECO 0000269|PubMed 15467833, ECO 0000269|PubMed 18424730, ECO 0000269|PubMed 7478590}. 
# PTM	CEAM1_HUMAN	Isoform 8  Phosphorylated on serine and threonine. {ECO 0000269|PubMed 14522961}. 
# Pfam	PF00047	ig
# Pfam	PF07686	V-set
# Pfam	PF13895	Ig_2
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-1566977	Fibronectin matrix formation
# Reactome	R-HSA-202733	Cell surface interactions at the vascular wall
# Reactome	R-HSA-6798695	Neutrophil degranulation
# RecName	Carcinoembryonic antigen-related cell adhesion molecule 1 {ECO	0000303|Ref.8}
# RefSeq	NP_001020083	NM_001024912.2. [P13688-8]
# RefSeq	NP_001171742	NM_001184813.1. [P13688-6]
# RefSeq	NP_001171744	NM_001184815.1. [P13688-5]
# RefSeq	NP_001171745	NM_001184816.1. [P13688-11]
# RefSeq	NP_001192273	NM_001205344.1. [P13688-10]
# RefSeq	NP_001703	NM_001712.4. [P13688-1]
# RefSeq	XP_011525508	XM_011527206.1. [P13688-4]
# SEQUENCE CAUTION	Sequence=AAA57141.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the immunoglobulin superfamily. CEA family. {ECO	0000305}. 
# SIMILARITY	Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO	0000305}. 
# SIMILARITY	Contains 3 Ig-like C2-type (immunoglobulin-like) domains. {ECO	0000305}. 
# SMART	SM00408	IGc2; 3
# SMART	SM00409	IG; 4
# SUBCELLULAR LOCATION	CEAM1_HUMAN	Cell projection, microvillus membrane {ECO 0000250|UniProtKB P31809}; Single-pass type I membrane protein {ECO 0000305}. Apical cell membrane {ECO 0000250|UniProtKB P31809}; Single-pass type I membrane protein {ECO 0000305}. Note=Colocalizes with CEACAM20 at the apical brush border of intestinal cells. {ECO 0000250|UniProtKB P31809}. 
# SUBCELLULAR LOCATION	CEAM1_HUMAN	Isoform 1  Cell membrane {ECO 0000250|UniProtKB P16573}; Single-pass type I membrane protein {ECO 0000250|UniProtKB P16573}. Lateral cell membrane {ECO 0000250|UniProtKB P16573}. Apical cell membrane {ECO 0000250|UniProtKB P16573}. Basal cell membrane {ECO 0000250|UniProtKB P16573}. Cell junction {ECO 0000269|PubMed 16291724}. Cell junction, adherens junction {ECO 0000250|UniProtKB P16573}. Note=Canalicular domain of hepatocyte plasma membranes. Found as a mixture of monomer, dimer and oligomer in the plasma membrane. Occurs predominantly as cis- dimers and/or small cis-oligomers in the cell junction regions. Found as dimer in the solution. Predominantly localized to the lateral cell membranes. {ECO 0000250|UniProtKB P16573}. 
# SUBCELLULAR LOCATION	CEAM1_HUMAN	Isoform 2  Secreted {ECO 0000269|PubMed 2025273}. 
# SUBCELLULAR LOCATION	CEAM1_HUMAN	Isoform 3  Secreted {ECO 0000269|PubMed 2025273}. 
# SUBCELLULAR LOCATION	CEAM1_HUMAN	Isoform 4  Secreted {ECO 0000269|PubMed 2025273}. 
# SUBCELLULAR LOCATION	CEAM1_HUMAN	Isoform 5  Cell membrane; Single-pass type I membrane protein. 
# SUBCELLULAR LOCATION	CEAM1_HUMAN	Isoform 6  Cell membrane; Single-pass type I membrane protein. 
# SUBCELLULAR LOCATION	CEAM1_HUMAN	Isoform 7  Cell membrane; Single-pass type I membrane protein. 
# SUBCELLULAR LOCATION	CEAM1_HUMAN	Isoform 8  Cell membrane {ECO 0000269|PubMed 14522961}; Single-pass type I membrane protein {ECO 0000250|UniProtKB P16573}. Cytoplasmic vesicle, secretory vesicle membrane {ECO 0000269|PubMed 14522961}. Lateral cell membrane {ECO 0000250|UniProtKB P16573}. Apical cell membrane {ECO 0000250|UniProtKB P16573}. Basal cell membrane {ECO 0000250|UniProtKB P16573}. Cell junction {ECO 0000269|PubMed 8018919}. Cell junction, adherens junction {ECO 0000250|UniProtKB P16573}. Note=Predominantly localized to the lateral cell membranes. Found as a mixture of monomer, dimer and oligomer in the plasma membrane. Occurs predominantly as cis- dimers and/or small cis-oligomers in the cell junction regions (By similarity). Co-localizes with ANXA2 in secretory vesicles and with S100A10/p11 at the plasma membrane (PubMed 14522961). {ECO 0000250|UniProtKB P16573, ECO 0000269|PubMed 14522961}. 
# SUBUNIT	CEAM1_HUMAN	Monomer. Oligomer. Heterodimer. Homodimer. Cis- dimer/oligomer (via Ig-like C2-type and/or via cytoplasmic domains); induced by trans-homophilic cell adhesion through an allosteric mechanism transmitted by the Ig-like V-type domain, and is regulated by intracellular calcium and calmodulin. Interacts (via cytoplasmic domain) with calmodulin in a calcium dependent manner; reduces homophilic cell adhesion through dissociation of dimer (By similarity). Isoform 1 interacts (via cytoplasmic domain) with PTPN11 (preferentially) and PTPN6; cis-homodimer form is preferred; this interaction is decreased by formation of Isoform 1 /Isoform 8 cis-heterodimers and is dependent on the monomer/dimer equilibrium; this interaction is phosphorylation- dependent (PubMed 23696226). Isoform 1 interacts with LYN (By similarity). Isoform 1 interacts (via cytoplasmic domain) with SRC (via SH2 domain); this interaction is regulated by trans- homophilic cell adhesion (PubMed 7478590). Isoform 1 interacts (via cytoplasmic domain) with LCK; mediates phosphorylation at Tyr-493 and Tyr-520 resulting in PTPN6 association. Isoform 1 interacts with PTPN6; this interaction is phosphorylation- dependent and causes a profound decrease in TCR stimulation- induced CD247 and ZAP70 phosphorylation. Isoform 1 interacts with TCR/CD3 complex through TCR beta chain and CD3E; colocalizes at the cell surface and upon stimulation of the TCR/CD3 complex recuits PTPN6 in the TCR/CD3 complex, resulting in dephosphorylation of CD247 and ZAP70 (PubMed 18424730). Isoform 1 interacts (via cytoplasmic domain) with SHC1 (via SH2 domain); SHC1 mediates interaction with INSR or EGFR in a Ser-508 phosphorylation-dependent manner (By similarity). Isoform 1 interacts with EGFR; the interaction is indirect (PubMed 15467833). Isoform 1 interacts with CSF3R; down-regulates the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (By similarity). Isoform 1 (phosphorylated form) interacts with TLR4 and SYK; recruits PTPN6 that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, leading to a reduction of the inflammasome activity (By similarity). Isoform 1 interacts with FLNA; inhibits cell migration and cell scattering by interfering with the interaction of FLNA with RALA (PubMed 16291724). Isoform 1 interacts (via cytoplasmic domain) with PXN; the interaction is phosphotyrosyl-dependent (PubMed 11035932). Isoform 1 interacts with KLRK1; recruits PTPN6 that dephosphorylates VAV1 (PubMed 23696226). Isoform 1 interacts with CEACAM8 (PubMed 11994468). Isoform 1 interacts with FASN; this interaction is insulin and phosphorylation-dependent; reduces fatty-acid synthase activity (By similarity). Interacts (via Ig- like V-type) with HAVCR2 (via Ig-like V-type); facilitates the maturation and cell surface expression of HAVCR2 thereby regulating T cell tolerance induction (PubMed 25363763). Isoform 8 interacts (via the cytoplasmic domain) with ANXA2; this interaction is regulated by phosphorylation and appears in the AIIt complex (PubMed 14522961). Interacts (via Lewis X moieties) with CD209 (via C-type lectin domain); this interaction is regulated by the glycosylation pattern of CEACAM1 on cell types and regulates contact between dendritic cells and neutrophils (PubMed 16246332). {ECO 0000250|UniProtKB P16573, ECO 0000250|UniProtKB P31809, ECO 0000269|PubMed 11035932, ECO 0000269|PubMed 11994468, ECO 0000269|PubMed 14522961, ECO 0000269|PubMed 15467833, ECO 0000269|PubMed 16246332, ECO 0000269|PubMed 16291724, ECO 0000269|PubMed 18424730, ECO 0000269|PubMed 23696226, ECO 0000269|PubMed 25363763, ECO 0000269|PubMed 7478590}. 
# SUPFAM	SSF48726	SSF48726; 4
# TISSUE SPECIFICITY	CEAM1_HUMAN	The predominant forms expressed by T cells are those containing a long cytoplasmic domain (PubMed 18424730). Expressed in granulocytes and lymphocytes. Leukocytes only express isoforms 6 and isoform 1 (PubMed 11994468). {ECO 0000269|PubMed 11994468, ECO 0000269|PubMed 18424730}. 
# TopDownProteomics	P13688-2	-. [P13688-2]
# UCSC	uc002otv	human. [P13688-1]
# WEB RESOURCE	CEAM1_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/CEACAM1ID40044ch19q13.html";
# WEB RESOURCE	CEAM1_HUMAN	Name=SeattleSNPs; URL="http //pga.gs.washington.edu/data/ceacam1/"; 
# eggNOG	ENOG410IFE1	Eukaryota
# eggNOG	ENOG410YR1P	LUCA
BLAST	swissprot:CEAM1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CEAM1_HUMAN
BioCyc	ZFISH:ENSG00000079385-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000079385-MONOMER
COXPRESdb	634	http://coxpresdb.jp/data/gene/634.shtml
CleanEx	HS_CEACAM1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CEACAM1
DIP	DIP-42683N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-42683N
DOI	10.1002/eji.201242676	http://dx.doi.org/10.1002/eji.201242676
DOI	10.1006/excr.1999.4610	http://dx.doi.org/10.1006/excr.1999.4610
DOI	10.1006/excr.2000.5026	http://dx.doi.org/10.1006/excr.2000.5026
DOI	10.1016/S0006-291X(05)80223-2	http://dx.doi.org/10.1016/S0006-291X(05)80223-2
DOI	10.1016/j.febslet.2005.09.089	http://dx.doi.org/10.1016/j.febslet.2005.09.089
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr0502065	http://dx.doi.org/10.1021/pr0502065
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DOI	10.1038/nature13848	http://dx.doi.org/10.1038/nature13848
DOI	10.1073/pnas.85.18.6959	http://dx.doi.org/10.1073/pnas.85.18.6959
DOI	10.1074/jbc.M309115200	http://dx.doi.org/10.1074/jbc.M309115200
DOI	10.1083/jcb.108.2.267	http://dx.doi.org/10.1083/jcb.108.2.267
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1107/S0907444906020737	http://dx.doi.org/10.1107/S0907444906020737
DOI	10.1111/j.1432-1033.1994.tb19022.x	http://dx.doi.org/10.1111/j.1432-1033.1994.tb19022.x
DOI	10.1111/j.1432-1033.1995.tb20676.x	http://dx.doi.org/10.1111/j.1432-1033.1995.tb20676.x
DOI	10.1128/MCB.13.2.1273	http://dx.doi.org/10.1128/MCB.13.2.1273
DOI	10.1172/JCI200421786	http://dx.doi.org/10.1172/JCI200421786
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1242/jcs.02660	http://dx.doi.org/10.1242/jcs.02660
DOI	10.4049/jimmunol.168.10.5139	http://dx.doi.org/10.4049/jimmunol.168.10.5139
DOI	10.4049/jimmunol.180.9.6085	http://dx.doi.org/10.4049/jimmunol.180.9.6085
DrugBank	DB00113	http://www.drugbank.ca/drugs/DB00113
EMBL	AC004785	http://www.ebi.ac.uk/ena/data/view/AC004785
EMBL	AC004785	http://www.ebi.ac.uk/ena/data/view/AC004785
EMBL	AC004785	http://www.ebi.ac.uk/ena/data/view/AC004785
EMBL	AC004785	http://www.ebi.ac.uk/ena/data/view/AC004785
EMBL	AC004785	http://www.ebi.ac.uk/ena/data/view/AC004785
EMBL	AC004785	http://www.ebi.ac.uk/ena/data/view/AC004785
EMBL	AC004785	http://www.ebi.ac.uk/ena/data/view/AC004785
EMBL	AY766113	http://www.ebi.ac.uk/ena/data/view/AY766113
EMBL	BC014473	http://www.ebi.ac.uk/ena/data/view/BC014473
EMBL	CH471126	http://www.ebi.ac.uk/ena/data/view/CH471126
EMBL	CH471126	http://www.ebi.ac.uk/ena/data/view/CH471126
EMBL	CH471126	http://www.ebi.ac.uk/ena/data/view/CH471126
EMBL	CH471126	http://www.ebi.ac.uk/ena/data/view/CH471126
EMBL	D12502	http://www.ebi.ac.uk/ena/data/view/D12502
EMBL	D90311	http://www.ebi.ac.uk/ena/data/view/D90311
EMBL	D90312	http://www.ebi.ac.uk/ena/data/view/D90312
EMBL	D90313	http://www.ebi.ac.uk/ena/data/view/D90313
EMBL	DQ989182	http://www.ebi.ac.uk/ena/data/view/DQ989182
EMBL	J03858	http://www.ebi.ac.uk/ena/data/view/J03858
EMBL	M69176	http://www.ebi.ac.uk/ena/data/view/M69176
EMBL	M72238	http://www.ebi.ac.uk/ena/data/view/M72238
EMBL	M72238	http://www.ebi.ac.uk/ena/data/view/M72238
EMBL	M76741	http://www.ebi.ac.uk/ena/data/view/M76741
EMBL	M76742	http://www.ebi.ac.uk/ena/data/view/M76742
EMBL	M76743	http://www.ebi.ac.uk/ena/data/view/M76743
EMBL	M76744	http://www.ebi.ac.uk/ena/data/view/M76744
EMBL	S71326	http://www.ebi.ac.uk/ena/data/view/S71326
EMBL	X14831	http://www.ebi.ac.uk/ena/data/view/X14831
EMBL	X16354	http://www.ebi.ac.uk/ena/data/view/X16354
EMBL	X16356	http://www.ebi.ac.uk/ena/data/view/X16356
EMBL	X67277	http://www.ebi.ac.uk/ena/data/view/X67277
Ensembl	ENST00000161559	http://www.ensembl.org/id/ENST00000161559
Ensembl	ENST00000352591	http://www.ensembl.org/id/ENST00000352591
Ensembl	ENST00000358394	http://www.ensembl.org/id/ENST00000358394
Ensembl	ENST00000403444	http://www.ensembl.org/id/ENST00000403444
Ensembl	ENST00000403461	http://www.ensembl.org/id/ENST00000403461
Ensembl	ENST00000599389	http://www.ensembl.org/id/ENST00000599389
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005911	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005911
GO_component	GO:0005912	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005912
GO_component	GO:0009925	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009925
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0016328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016328
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030658	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030658
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0003779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003779
GO_function	GO:0015125	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015125
GO_function	GO:0019900	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019900
GO_function	GO:0019903	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019903
GO_function	GO:0031005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031005
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_function	GO:0046983	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046983
GO_function	GO:1990782	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990782
GO_process	GO:0001525	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001525
GO_process	GO:0001558	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001558
GO_process	GO:0001568	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001568
GO_process	GO:0001915	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001915
GO_process	GO:0002859	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002859
GO_process	GO:0006469	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006469
GO_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GO_process	GO:0007156	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007156
GO_process	GO:0007229	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007229
GO_process	GO:0010594	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010594
GO_process	GO:0014066	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014066
GO_process	GO:0015721	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015721
GO_process	GO:0016477	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016477
GO_process	GO:0030334	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030334
GO_process	GO:0030853	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030853
GO_process	GO:0032692	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032692
GO_process	GO:0032869	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032869
GO_process	GO:0035726	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035726
GO_process	GO:0038016	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0038016
GO_process	GO:0038158	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0038158
GO_process	GO:0042058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042058
GO_process	GO:0043116	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043116
GO_process	GO:0043318	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043318
GO_process	GO:0044319	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044319
GO_process	GO:0045601	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045601
GO_process	GO:0045717	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045717
GO_process	GO:0050860	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050860
GO_process	GO:0050900	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050900
GO_process	GO:0051055	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051055
GO_process	GO:0060312	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060312
GO_process	GO:0070372	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070372
GO_process	GO:0090331	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090331
GO_process	GO:0098609	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098609
GO_process	GO:1901143	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901143
GO_process	GO:1903385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903385
GO_process	GO:1903670	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903670
GO_process	GO:2000346	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000346
GO_process	GO:2001214	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001214
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0003013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003013
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0008283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008283
GOslim_process	GO:0009056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0048646	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048646
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
Gene3D	2.60.40.10	http://www.cathdb.info/version/latest/superfamily/2.60.40.10
GeneCards	CEACAM1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CEACAM1
GeneID	634	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=634
GeneTree	ENSGT00760000119187	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119187
H-InvDB	HIX0017795	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0017795
HGNC	HGNC:1814	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1814
HOVERGEN	HBG007922	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG007922&db=HOVERGEN
HPA	CAB002146	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB002146
HPA	HPA011041	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA011041
InParanoid	P13688	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P13688
IntAct	P13688	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P13688*
InterPro	IPR003598	http://www.ebi.ac.uk/interpro/entry/IPR003598
InterPro	IPR003599	http://www.ebi.ac.uk/interpro/entry/IPR003599
InterPro	IPR007110	http://www.ebi.ac.uk/interpro/entry/IPR007110
InterPro	IPR013106	http://www.ebi.ac.uk/interpro/entry/IPR013106
InterPro	IPR013151	http://www.ebi.ac.uk/interpro/entry/IPR013151
InterPro	IPR013783	http://www.ebi.ac.uk/interpro/entry/IPR013783
Jabion	634	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=634
KEGG_Brite	ko04090	http://www.genome.jp/dbget-bin/www_bget?ko04090
KEGG_Brite	ko04516	http://www.genome.jp/dbget-bin/www_bget?ko04516
KEGG_Gene	hsa:634	http://www.genome.jp/dbget-bin/www_bget?hsa:634
KEGG_Orthology	KO:K06499	http://www.genome.jp/dbget-bin/www_bget?KO:K06499
MIM	109770	http://www.ncbi.nlm.nih.gov/omim/109770
MINT	MINT-5002435	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5002435
OMA	NDPPNKM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NDPPNKM
OrthoDB	EOG091G0AMM	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0AMM
PDB	2GK2	http://www.ebi.ac.uk/pdbe-srv/view/entry/2GK2
PDB	4QXW	http://www.ebi.ac.uk/pdbe-srv/view/entry/4QXW
PDB	4WHD	http://www.ebi.ac.uk/pdbe-srv/view/entry/4WHD
PDB	5DZL	http://www.ebi.ac.uk/pdbe-srv/view/entry/5DZL
PDBsum	2GK2	http://www.ebi.ac.uk/pdbsum/2GK2
PDBsum	4QXW	http://www.ebi.ac.uk/pdbsum/4QXW
PDBsum	4WHD	http://www.ebi.ac.uk/pdbsum/4WHD
PDBsum	5DZL	http://www.ebi.ac.uk/pdbsum/5DZL
PROSITE	PS50835	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50835
PSORT	swissprot:CEAM1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CEAM1_HUMAN
PSORT-B	swissprot:CEAM1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CEAM1_HUMAN
PSORT2	swissprot:CEAM1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CEAM1_HUMAN
Pfam	PF00047	http://pfam.xfam.org/family/PF00047
Pfam	PF07686	http://pfam.xfam.org/family/PF07686
Pfam	PF13895	http://pfam.xfam.org/family/PF13895
PharmGKB	PA26358	http://www.pharmgkb.org/do/serve?objId=PA26358&objCls=Gene
Phobius	swissprot:CEAM1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CEAM1_HUMAN
PhylomeDB	P13688	http://phylomedb.org/?seqid=P13688
ProteinModelPortal	P13688	http://www.proteinmodelportal.org/query/uniprot/P13688
PubMed	11035932	http://www.ncbi.nlm.nih.gov/pubmed/11035932
PubMed	11501563	http://www.ncbi.nlm.nih.gov/pubmed/11501563
PubMed	11994468	http://www.ncbi.nlm.nih.gov/pubmed/11994468
PubMed	14522961	http://www.ncbi.nlm.nih.gov/pubmed/14522961
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	15467833	http://www.ncbi.nlm.nih.gov/pubmed/15467833
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16246332	http://www.ncbi.nlm.nih.gov/pubmed/16246332
PubMed	16291724	http://www.ncbi.nlm.nih.gov/pubmed/16291724
PubMed	16335952	http://www.ncbi.nlm.nih.gov/pubmed/16335952
PubMed	16929097	http://www.ncbi.nlm.nih.gov/pubmed/16929097
PubMed	18424730	http://www.ncbi.nlm.nih.gov/pubmed/18424730
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	2025273	http://www.ncbi.nlm.nih.gov/pubmed/2025273
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23696226	http://www.ncbi.nlm.nih.gov/pubmed/23696226
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	2457922	http://www.ncbi.nlm.nih.gov/pubmed/2457922
PubMed	25363763	http://www.ncbi.nlm.nih.gov/pubmed/25363763
PubMed	2537311	http://www.ncbi.nlm.nih.gov/pubmed/2537311
PubMed	7478590	http://www.ncbi.nlm.nih.gov/pubmed/7478590
PubMed	7628460	http://www.ncbi.nlm.nih.gov/pubmed/7628460
PubMed	8018919	http://www.ncbi.nlm.nih.gov/pubmed/8018919
PubMed	8055923	http://www.ncbi.nlm.nih.gov/pubmed/8055923
PubMed	8423792	http://www.ncbi.nlm.nih.gov/pubmed/8423792
Reactome	R-HSA-1566977	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1566977
Reactome	R-HSA-202733	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-202733
Reactome	R-HSA-6798695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6798695
RefSeq	NP_001020083	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001020083
RefSeq	NP_001171742	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001171742
RefSeq	NP_001171744	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001171744
RefSeq	NP_001171745	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001171745
RefSeq	NP_001192273	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001192273
RefSeq	NP_001703	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001703
RefSeq	XP_011525508	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011525508
SMART	SM00408	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00408
SMART	SM00409	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00409
SMR	P13688	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P13688
STRING	9606.ENSP00000161559	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000161559&targetmode=cogs
SUPFAM	SSF48726	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48726
UCSC	uc002otv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002otv&org=rat
UniGene	Hs.512682	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.512682
UniProtKB	CEAM1_HUMAN	http://www.uniprot.org/uniprot/CEAM1_HUMAN
UniProtKB-AC	P13688	http://www.uniprot.org/uniprot/P13688
charge	swissprot:CEAM1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CEAM1_HUMAN
eggNOG	ENOG410IFE1	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IFE1
eggNOG	ENOG410YR1P	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YR1P
epestfind	swissprot:CEAM1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CEAM1_HUMAN
garnier	swissprot:CEAM1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CEAM1_HUMAN
helixturnhelix	swissprot:CEAM1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CEAM1_HUMAN
hmoment	swissprot:CEAM1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CEAM1_HUMAN
iep	swissprot:CEAM1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CEAM1_HUMAN
inforesidue	swissprot:CEAM1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CEAM1_HUMAN
neXtProt	NX_P13688	http://www.nextprot.org/db/entry/NX_P13688
octanol	swissprot:CEAM1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CEAM1_HUMAN
pepcoil	swissprot:CEAM1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CEAM1_HUMAN
pepdigest	swissprot:CEAM1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CEAM1_HUMAN
pepinfo	swissprot:CEAM1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CEAM1_HUMAN
pepnet	swissprot:CEAM1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CEAM1_HUMAN
pepstats	swissprot:CEAM1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CEAM1_HUMAN
pepwheel	swissprot:CEAM1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CEAM1_HUMAN
pepwindow	swissprot:CEAM1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CEAM1_HUMAN
sigcleave	swissprot:CEAM1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CEAM1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	RHAG_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q02094-1; Sequence=Displayed; Name=2; IsoId=Q02094-2; Sequence=VSP_047629, VSP_047630; 
# AltName	RHAG_HUMAN	CD241
# AltName	RHAG_HUMAN	Erythrocyte membrane glycoprotein Rh50
# AltName	RHAG_HUMAN	Erythrocyte plasma membrane 50 kDa glycoprotein
# AltName	RHAG_HUMAN	Rhesus blood group family type A glycoprotein
# AltName	RHAG_HUMAN	Rhesus blood group-associated ammonia channel
# AltName	RHAG_HUMAN	Rhesus blood group-associated glycoprotein
# CCDS	CCDS4927	-. [Q02094-1]
# ChiTaRS	RHAG	human
# DISEASE	RHAG_HUMAN	Overhydrated hereditary stomatocytosis (OHST) [MIM 185000]  An autosomal dominant disorder of red cell membrane permeability to monovalent cations, characterized by macrocytic hemolytic anemia of fluctuating severity, circulating erythrocytes with slit-like lucencies (stomata) evident on fixed, stained peripheral blood smears. OHST red cells exhibit cation leak, resulting in elevated cell sodium content with reduced potassium content. The disease is marked by splenomegaly or hepatosplenomegaly, cholelithiasis and a strong tendency for iron overload. {ECO 0000269|PubMed 18931342, ECO 0000269|PubMed 21849667, ECO 0000269|PubMed 22012326}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	RHAG_HUMAN	Regulator type Rh-null hemolytic anemia (RHN) [MIM 268150]  Form of chronic hemolytic anemia in which the red blood cells have a stomatocytosis and spherocytosis morphology, an increased osmotic fragility, an altered ion transport system, and abnormal membrane phospholipid organization. {ECO 0000269|PubMed 10467273, ECO 0000269|PubMed 8563755, ECO 0000269|PubMed 9454778, ECO 0000269|PubMed 9716608}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000371175	ENSP00000360217; ENSG00000112077. [Q02094-1]
# ExpressionAtlas	Q02094	baseline and differential
# FUNCTION	RHAG_HUMAN	Associated with rhesus blood group antigen expression (PubMed 19744193). May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane (PubMed 11062476, PubMed 11861637). Involved in ammonia transport across the erythrocyte membrane (PubMed 21849667, PubMed 22012326). Seems to act in monovalent cation transport (PubMed 18931342, PubMed 21849667). {ECO 0000269|PubMed 11062476, ECO 0000269|PubMed 11861637, ECO 0000269|PubMed 18931342, ECO 0000269|PubMed 19744193, ECO 0000269|PubMed 21849667, ECO 0000269|PubMed 22012326}. 
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_function	GO:0008519	ammonium transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0022840	leak channel activity; IDA:UniProtKB.
# GO_function	GO:0030506	ankyrin binding; IPI:UniProtKB.
# GO_function	GO:0035379	carbon dioxide transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0006873	cellular ion homeostasis; IDA:UniProtKB.
# GO_process	GO:0015670	carbon dioxide transport; IDA:UniProtKB.
# GO_process	GO:0015672	monovalent inorganic cation transport; IDA:UniProtKB.
# GO_process	GO:0015695	organic cation transport; IBA:GO_Central.
# GO_process	GO:0015696	ammonium transport; IDA:UniProtKB.
# GO_process	GO:0015701	bicarbonate transport; TAS:Reactome.
# GO_process	GO:0019740	nitrogen utilization; IBA:GO_Central.
# GO_process	GO:0048821	erythrocyte development; IEA:Ensembl.
# GO_process	GO:0060586	multicellular organismal iron ion homeostasis; IEA:Ensembl.
# GO_process	GO:0072488	ammonium transmembrane transport; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0008092	cytoskeletal protein binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.10.3430.10	-; 1.
# Genevisible	Q02094	HS
# HGNC	HGNC:10006	RHAG
# InterPro	IPR001905	Ammonium_transpt
# InterPro	IPR002229	RhesusRHD
# InterPro	IPR024041	NH4_transpt_AmtB-like_dom
# InterPro	IPR029020	Ammonium/urea_transptr
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Brite	ko04090	 Cellular antigens
# KEGG_Disease	H00232	[Hematologic disease] Familial pseudohyperkalemia (FP)
# KEGG_Disease	H01214	[Hematologic disease] Rh-deficiency syndrome
# MIM	180297	gene
# MIM	185000	phenotype
# MIM	268150	phenotype
# Organism	RHAG_HUMAN	Homo sapiens (Human)
# Orphanet	3203	Overhydrated hereditary stomatocytosis
# Orphanet	71275	Rh deficiency syndrome
# PANTHER	PTHR11730	PTHR11730
# PIR	S29124	S29124
# PRINTS	PR00342	RHESUSRHD
# PTM	RHAG_HUMAN	Glycoylated. {ECO 0000269|PubMed 18931342, ECO 0000269|PubMed 22012326}. 
# Pfam	PF00909	Ammonium_transp
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-1237044	Erythrocytes take up carbon dioxide and release oxygen
# Reactome	R-HSA-1247673	Erythrocytes take up oxygen and release carbon dioxide
# Reactome	R-HSA-444411	Rhesus glycoproteins mediate ammonium transport
# RecName	RHAG_HUMAN	Ammonium transporter Rh type A
# RefSeq	NP_000315	NM_000324.2. [Q02094-1]
# SIMILARITY	Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	RHAG_HUMAN	Membrane {ECO 0000269|PubMed 18931342, ECO 0000269|PubMed 22012326}; Multi-pass membrane protein. 
# SUBUNIT	RHAG_HUMAN	Heterotetramer. 
# SUPFAM	SSF111352	SSF111352
# TCDB	1.A.11.4	the ammonium transporter channel (amt) family
# TISSUE SPECIFICITY	RHAG_HUMAN	Erythrocytes. {ECO 0000269|PubMed 18931342, ECO 0000269|PubMed 22012326, ECO 0000269|PubMed 9473510}. 
# UCSC	uc003ozk	human. [Q02094-1]
# eggNOG	ENOG410XTF8	LUCA
# eggNOG	KOG3796	Eukaryota
BLAST	swissprot:RHAG_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:RHAG_HUMAN
BioCyc	ZFISH:ENSG00000112077-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000112077-MONOMER
COXPRESdb	6005	http://coxpresdb.jp/data/gene/6005.shtml
CleanEx	HS_RHAG	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_RHAG
DOI	10.1002/(SICI)1096-8652(199909)62:1<25::AID-AJH5>3.0.CO	http://dx.doi.org/10.1002/(SICI)1096-8652(199909)62:1<25::AID-AJH5>3.0.CO
DOI	10.1006/bbrc.1997.8023	http://dx.doi.org/10.1006/bbrc.1997.8023
DOI	10.1038/81656	http://dx.doi.org/10.1038/81656
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng0296-168	http://dx.doi.org/10.1038/ng0296-168
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/bj2561043	http://dx.doi.org/10.1042/bj2561043
DOI	10.1042/bj2870223	http://dx.doi.org/10.1042/bj2870223
DOI	10.1074/jbc.273.4.2207	http://dx.doi.org/10.1074/jbc.273.4.2207
DOI	10.1074/jbc.C200060200	http://dx.doi.org/10.1074/jbc.C200060200
DOI	10.1074/jbc.M311853200	http://dx.doi.org/10.1074/jbc.M311853200
DOI	10.1111/j.1423-0410.2009.01243.x	http://dx.doi.org/10.1111/j.1423-0410.2009.01243.x
DOI	10.1152/ajpcell.00054.2011	http://dx.doi.org/10.1152/ajpcell.00054.2011
DOI	10.1152/ajpcell.00092.2011	http://dx.doi.org/10.1152/ajpcell.00092.2011
DOI	10.1182/blood-2008-07-171140	http://dx.doi.org/10.1182/blood-2008-07-171140
EMBL	AF031548	http://www.ebi.ac.uk/ena/data/view/AF031548
EMBL	AF031549	http://www.ebi.ac.uk/ena/data/view/AF031549
EMBL	AF237382	http://www.ebi.ac.uk/ena/data/view/AF237382
EMBL	AF237383	http://www.ebi.ac.uk/ena/data/view/AF237383
EMBL	AF237384	http://www.ebi.ac.uk/ena/data/view/AF237384
EMBL	AF237385	http://www.ebi.ac.uk/ena/data/view/AF237385
EMBL	AF237386	http://www.ebi.ac.uk/ena/data/view/AF237386
EMBL	AF237387	http://www.ebi.ac.uk/ena/data/view/AF237387
EMBL	AK313505	http://www.ebi.ac.uk/ena/data/view/AK313505
EMBL	AL121950	http://www.ebi.ac.uk/ena/data/view/AL121950
EMBL	AL121950	http://www.ebi.ac.uk/ena/data/view/AL121950
EMBL	AL590244	http://www.ebi.ac.uk/ena/data/view/AL590244
EMBL	AL590244	http://www.ebi.ac.uk/ena/data/view/AL590244
EMBL	CH471081	http://www.ebi.ac.uk/ena/data/view/CH471081
EMBL	CH471081	http://www.ebi.ac.uk/ena/data/view/CH471081
EMBL	X64594	http://www.ebi.ac.uk/ena/data/view/X64594
Ensembl	ENST00000371175	http://www.ensembl.org/id/ENST00000371175
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0008519	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008519
GO_function	GO:0022840	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022840
GO_function	GO:0030506	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030506
GO_function	GO:0035379	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035379
GO_process	GO:0006873	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006873
GO_process	GO:0015670	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015670
GO_process	GO:0015672	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015672
GO_process	GO:0015695	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015695
GO_process	GO:0015696	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015696
GO_process	GO:0015701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015701
GO_process	GO:0019740	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019740
GO_process	GO:0048821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048821
GO_process	GO:0060586	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060586
GO_process	GO:0072488	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072488
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0008092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.10.3430.10	http://www.cathdb.info/version/latest/superfamily/1.10.3430.10
GeneCards	RHAG	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=RHAG
GeneID	6005	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6005
GeneTree	ENSGT00390000005787	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000005787
H-InvDB	HIX0005947	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0005947
HGNC	HGNC:10006	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10006
HOGENOM	HOG000007656	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007656&db=HOGENOM6
HOVERGEN	HBG004374	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004374&db=HOVERGEN
HPA	HPA055331	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA055331
InParanoid	Q02094	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q02094
InterPro	IPR001905	http://www.ebi.ac.uk/interpro/entry/IPR001905
InterPro	IPR002229	http://www.ebi.ac.uk/interpro/entry/IPR002229
InterPro	IPR024041	http://www.ebi.ac.uk/interpro/entry/IPR024041
InterPro	IPR029020	http://www.ebi.ac.uk/interpro/entry/IPR029020
Jabion	6005	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6005
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Brite	ko04090	http://www.genome.jp/dbget-bin/www_bget?ko04090
KEGG_Disease	H00232	http://www.genome.jp/dbget-bin/www_bget?H00232
KEGG_Disease	H01214	http://www.genome.jp/dbget-bin/www_bget?H01214
KEGG_Gene	hsa:6005	http://www.genome.jp/dbget-bin/www_bget?hsa:6005
KEGG_Orthology	KO:K06580	http://www.genome.jp/dbget-bin/www_bget?KO:K06580
MIM	180297	http://www.ncbi.nlm.nih.gov/omim/180297
MIM	185000	http://www.ncbi.nlm.nih.gov/omim/185000
MIM	268150	http://www.ncbi.nlm.nih.gov/omim/268150
OMA	VTAYACS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VTAYACS
Orphanet	3203	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=3203
Orphanet	71275	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=71275
PANTHER	PTHR11730	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11730
PRINTS	PR00342	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00342
PSORT	swissprot:RHAG_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:RHAG_HUMAN
PSORT-B	swissprot:RHAG_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:RHAG_HUMAN
PSORT2	swissprot:RHAG_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:RHAG_HUMAN
Pfam	PF00909	http://pfam.xfam.org/family/PF00909
PharmGKB	PA34381	http://www.pharmgkb.org/do/serve?objId=PA34381&objCls=Gene
Phobius	swissprot:RHAG_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:RHAG_HUMAN
PhylomeDB	Q02094	http://phylomedb.org/?seqid=Q02094
ProteinModelPortal	Q02094	http://www.proteinmodelportal.org/query/uniprot/Q02094
PubMed	10467273	http://www.ncbi.nlm.nih.gov/pubmed/10467273
PubMed	11062476	http://www.ncbi.nlm.nih.gov/pubmed/11062476
PubMed	11861637	http://www.ncbi.nlm.nih.gov/pubmed/11861637
PubMed	1417776	http://www.ncbi.nlm.nih.gov/pubmed/1417776
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	14966114	http://www.ncbi.nlm.nih.gov/pubmed/14966114
PubMed	18931342	http://www.ncbi.nlm.nih.gov/pubmed/18931342
PubMed	19744193	http://www.ncbi.nlm.nih.gov/pubmed/19744193
PubMed	21849667	http://www.ncbi.nlm.nih.gov/pubmed/21849667
PubMed	22012326	http://www.ncbi.nlm.nih.gov/pubmed/22012326
PubMed	3146980	http://www.ncbi.nlm.nih.gov/pubmed/3146980
PubMed	8563755	http://www.ncbi.nlm.nih.gov/pubmed/8563755
PubMed	9442063	http://www.ncbi.nlm.nih.gov/pubmed/9442063
PubMed	9454778	http://www.ncbi.nlm.nih.gov/pubmed/9454778
PubMed	9473510	http://www.ncbi.nlm.nih.gov/pubmed/9473510
PubMed	9716608	http://www.ncbi.nlm.nih.gov/pubmed/9716608
Reactome	R-HSA-1237044	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1237044
Reactome	R-HSA-1247673	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1247673
Reactome	R-HSA-444411	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-444411
RefSeq	NP_000315	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000315
STRING	9606.ENSP00000360217	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000360217&targetmode=cogs
SUPFAM	SSF111352	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF111352
TCDB	1.A.11.4	http://www.tcdb.org/search/result.php?tc=1.A.11.4
UCSC	uc003ozk	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ozk&org=rat
UniGene	Hs.120950	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.120950
UniProtKB	RHAG_HUMAN	http://www.uniprot.org/uniprot/RHAG_HUMAN
UniProtKB-AC	Q02094	http://www.uniprot.org/uniprot/Q02094
charge	swissprot:RHAG_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:RHAG_HUMAN
eggNOG	ENOG410XTF8	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XTF8
eggNOG	KOG3796	http://eggnogapi.embl.de/nog_data/html/tree/KOG3796
epestfind	swissprot:RHAG_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:RHAG_HUMAN
garnier	swissprot:RHAG_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:RHAG_HUMAN
helixturnhelix	swissprot:RHAG_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:RHAG_HUMAN
hmoment	swissprot:RHAG_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:RHAG_HUMAN
iep	swissprot:RHAG_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:RHAG_HUMAN
inforesidue	swissprot:RHAG_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:RHAG_HUMAN
neXtProt	NX_Q02094	http://www.nextprot.org/db/entry/NX_Q02094
octanol	swissprot:RHAG_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:RHAG_HUMAN
pepcoil	swissprot:RHAG_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:RHAG_HUMAN
pepdigest	swissprot:RHAG_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:RHAG_HUMAN
pepinfo	swissprot:RHAG_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:RHAG_HUMAN
pepnet	swissprot:RHAG_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:RHAG_HUMAN
pepstats	swissprot:RHAG_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:RHAG_HUMAN
pepwheel	swissprot:RHAG_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:RHAG_HUMAN
pepwindow	swissprot:RHAG_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:RHAG_HUMAN
sigcleave	swissprot:RHAG_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:RHAG_HUMAN
## Database	ID	URL or Descriptions
# AltName	SFXN1_HUMAN	Tricarboxylate carrier protein
# BioGrid	125107	53
# ChiTaRS	SFXN1	human
# Ensembl	ENST00000321442	ENSP00000316905; ENSG00000164466
# ExpressionAtlas	Q9H9B4	baseline and differential
# FUNCTION	SFXN1_HUMAN	Might be involved in the transport of a component required for iron utilization into or out of the mitochondria. 
# GO_component	GO:0005739	mitochondrion; IDA:HPA.
# GO_component	GO:0005743	mitochondrial inner membrane; IEA:Ensembl.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015075	ion transmembrane transporter activity; IEA:InterPro.
# GO_process	GO:0006826	iron ion transport; IEA:Ensembl.
# GO_process	GO:0030218	erythrocyte differentiation; IEA:Ensembl.
# GO_process	GO:0055072	iron ion homeostasis; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0042592	homeostatic process
# Genevisible	Q9H9B4	HS
# HGNC	HGNC:16085	SFXN1
# IntAct	Q9H9B4	16
# InterPro	IPR004686	Mtc
# MIM	615569	gene
# Organism	SFXN1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11153	PTHR11153
# Pfam	PF03820	Mtc
# Proteomes	UP000005640	Chromosome 5
# RecName	SFXN1_HUMAN	Sideroflexin-1
# RefSeq	NP_001309906	NM_001322977.1
# RefSeq	NP_073591	NM_022754.6
# SEQUENCE CAUTION	Sequence=AAH20517.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14003.1; Type=Miscellaneous discrepancy; Note=Cloning artifact.; Evidence={ECO	0000305}; Sequence=BAB14318.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
# SIMILARITY	Belongs to the sideroflexin family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	SFXN1_HUMAN	Mitochondrion membrane {ECO 0000250}; Multi- pass membrane protein {ECO 0000250}. 
# TIGRFAMs	TIGR00798	mtc
# UCSC	uc003mda	human
# eggNOG	ENOG410YU8V	LUCA
# eggNOG	KOG3767	Eukaryota
BLAST	swissprot:SFXN1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SFXN1_HUMAN
BioCyc	ZFISH:ENSG00000164466-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000164466-MONOMER
COXPRESdb	94081	http://coxpresdb.jp/data/gene/94081.shtml
CleanEx	HS_SFXN1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SFXN1
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AC091393	http://www.ebi.ac.uk/ena/data/view/AC091393
EMBL	AF327346	http://www.ebi.ac.uk/ena/data/view/AF327346
EMBL	AK022287	http://www.ebi.ac.uk/ena/data/view/AK022287
EMBL	AK022938	http://www.ebi.ac.uk/ena/data/view/AK022938
EMBL	AK056915	http://www.ebi.ac.uk/ena/data/view/AK056915
EMBL	BC020517	http://www.ebi.ac.uk/ena/data/view/BC020517
EMBL	BC063241	http://www.ebi.ac.uk/ena/data/view/BC063241
EMBL	BX648188	http://www.ebi.ac.uk/ena/data/view/BX648188
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
Ensembl	ENST00000321442	http://www.ensembl.org/id/ENST00000321442
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015075	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015075
GO_process	GO:0006826	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006826
GO_process	GO:0030218	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030218
GO_process	GO:0055072	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GeneCards	SFXN1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SFXN1
GeneID	94081	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=94081
GeneTree	ENSGT00390000002026	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002026
HGNC	HGNC:16085	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16085
HOGENOM	HOG000203440	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000203440&db=HOGENOM6
HOVERGEN	HBG056083	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG056083&db=HOVERGEN
HPA	HPA019543	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA019543
HPA	HPA063745	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA063745
InParanoid	Q9H9B4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9H9B4
IntAct	Q9H9B4	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9H9B4*
InterPro	IPR004686	http://www.ebi.ac.uk/interpro/entry/IPR004686
Jabion	94081	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=94081
KEGG_Gene	hsa:94081	http://www.genome.jp/dbget-bin/www_bget?hsa:94081
MIM	615569	http://www.ncbi.nlm.nih.gov/omim/615569
MINT	MINT-1151298	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1151298
OMA	SAVIFWQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SAVIFWQ
OrthoDB	EOG091G0BOU	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0BOU
PANTHER	PTHR11153	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11153
PSORT	swissprot:SFXN1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SFXN1_HUMAN
PSORT-B	swissprot:SFXN1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SFXN1_HUMAN
PSORT2	swissprot:SFXN1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SFXN1_HUMAN
Pfam	PF03820	http://pfam.xfam.org/family/PF03820
PharmGKB	PA38090	http://www.pharmgkb.org/do/serve?objId=PA38090&objCls=Gene
Phobius	swissprot:SFXN1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SFXN1_HUMAN
PhylomeDB	Q9H9B4	http://phylomedb.org/?seqid=Q9H9B4
ProteinModelPortal	Q9H9B4	http://www.proteinmodelportal.org/query/uniprot/Q9H9B4
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
RefSeq	NP_001309906	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001309906
RefSeq	NP_073591	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_073591
STRING	9606.ENSP00000316905	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000316905&targetmode=cogs
TIGRFAMs	TIGR00798	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00798
UCSC	uc003mda	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003mda&org=rat
UniGene	Hs.369440	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.369440
UniGene	Hs.732081	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.732081
UniProtKB	SFXN1_HUMAN	http://www.uniprot.org/uniprot/SFXN1_HUMAN
UniProtKB-AC	Q9H9B4	http://www.uniprot.org/uniprot/Q9H9B4
charge	swissprot:SFXN1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SFXN1_HUMAN
eggNOG	ENOG410YU8V	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YU8V
eggNOG	KOG3767	http://eggnogapi.embl.de/nog_data/html/tree/KOG3767
epestfind	swissprot:SFXN1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SFXN1_HUMAN
garnier	swissprot:SFXN1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SFXN1_HUMAN
helixturnhelix	swissprot:SFXN1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SFXN1_HUMAN
hmoment	swissprot:SFXN1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SFXN1_HUMAN
iep	swissprot:SFXN1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SFXN1_HUMAN
inforesidue	swissprot:SFXN1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SFXN1_HUMAN
neXtProt	NX_Q9H9B4	http://www.nextprot.org/db/entry/NX_Q9H9B4
octanol	swissprot:SFXN1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SFXN1_HUMAN
pepcoil	swissprot:SFXN1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SFXN1_HUMAN
pepdigest	swissprot:SFXN1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SFXN1_HUMAN
pepinfo	swissprot:SFXN1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SFXN1_HUMAN
pepnet	swissprot:SFXN1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SFXN1_HUMAN
pepstats	swissprot:SFXN1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SFXN1_HUMAN
pepwheel	swissprot:SFXN1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SFXN1_HUMAN
pepwindow	swissprot:SFXN1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SFXN1_HUMAN
sigcleave	swissprot:SFXN1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SFXN1_HUMAN
## Database	ID	URL or Descriptions
# AltName	SL9A4_HUMAN	Na(+)/H(+) exchanger 4
# AltName	SL9A4_HUMAN	Solute carrier family 9 member 4
# BioGrid	132934	2
# CAUTION	The number, localization and denomination of hydrophobic domains in the Na(+)/H(+) exchangers vary among authors. {ECO	0000305}.
# Ensembl	ENST00000295269	ENSP00000295269; ENSG00000180251
# FUNCTION	SL9A4_HUMAN	Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained intracellular acidification-dependence manner. Activated by 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) in a sustained intracellular acidification-dependence manner. Affects potassium/proton exchange as well as sodium/proton and lithium/proton exchange. In basolateral cell membrane, participates in homeostatic control of intracellular pH, and may play a role in proton extrusion in order to achieve transepithelial HCO3(-) secretion. In apical cell membrane may be involved in mediating sodium absorption. Requires for normal levels of gastric acid secretion, secretory membrane development, parietal cell maturation and/or differentiation and at least secondarily for chief cell differentiation (By similarity). {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016324	apical plasma membrane; IEA:UniProtKB-SubCell.
# GO_function	SL9A4_HUMAN	GO 0015385 sodium proton antiporter activity; IBA GO_Central.
# GO_function	SL9A4_HUMAN	GO 0015386 potassium proton antiporter activity; IBA GO_Central.
# GO_process	GO:0001696	gastric acid secretion; IEA:Ensembl.
# GO_process	GO:0002064	epithelial cell development; IEA:Ensembl.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0051453	regulation of intracellular pH; IBA:GO_Central.
# GO_process	GO:0071805	potassium ion transmembrane transport; IBA:GO_Central.
# GO_process	GO:0098719	sodium ion import across plasma membrane; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# HGNC	HGNC:11077	SLC9A4
# InterPro	IPR001953	Na/H_exchanger_2
# InterPro	IPR004709	NaH_exchanger
# InterPro	IPR006153	Cation/H_exchanger
# InterPro	IPR018422	Cation/H_exchanger_CPA1
# InterPro	IPR032103	NHE_CaM-bd
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04971	Gastric acid secretion
# MIM	600531	gene
# Organism	SL9A4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10110	PTHR10110
# PRINTS	PR01084	NAHEXCHNGR
# PRINTS	PR01086	NAHEXCHNGR2
# PTM	SL9A4_HUMAN	May be phosphorylated. {ECO 0000250}. 
# Pfam	PF00999	Na_H_Exchanger
# Pfam	PF16644	NEXCaM_BD
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-425986	Sodium/Proton exchangers
# RecName	SL9A4_HUMAN	Sodium/hydrogen exchanger 4
# RefSeq	NP_001011552	NM_001011552.3
# SIMILARITY	Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	SL9A4_HUMAN	Apical cell membrane {ECO 0000250}; Multi- pass membrane protein {ECO 0000250}. Basolateral cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Cytoplasmic granule membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Note=Found in zymogen granule membranes. {ECO 0000250}. 
# SUBUNIT	Interacts with CHP1 and CHP2. {ECO	0000250}. 
# TCDB	2.A.36.1.18:the monovalent cation	proton antiporter-1 (cpa1) family
# TIGRFAMs	TIGR00840	b_cpa1
# UCSC	uc002tbz	human
# eggNOG	COG0025	LUCA
# eggNOG	KOG1966	Eukaryota
BLAST	swissprot:SL9A4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SL9A4_HUMAN
COXPRESdb	389015	http://coxpresdb.jp/data/gene/389015.shtml
CleanEx	HS_SLC9A4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC9A4
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AC007278	http://www.ebi.ac.uk/ena/data/view/AC007278
EMBL	AL833048	http://www.ebi.ac.uk/ena/data/view/AL833048
EMBL	CR627411	http://www.ebi.ac.uk/ena/data/view/CR627411
Ensembl	ENST00000295269	http://www.ensembl.org/id/ENST00000295269
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_function	GO:0015385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015385
GO_function	GO:0015386	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015386
GO_process	GO:0001696	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001696
GO_process	GO:0002064	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002064
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GO_process	GO:0098719	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098719
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC9A4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC9A4
GeneID	389015	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=389015
GeneTree	ENSGT00760000119074	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119074
H-InvDB	HIX0017462	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0017462
HGNC	HGNC:11077	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11077
HOGENOM	HOG000247044	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000247044&db=HOGENOM6
HOVERGEN	HBG052615	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052615&db=HOVERGEN
HPA	HPA036096	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA036096
InParanoid	Q6AI14	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6AI14
InterPro	IPR001953	http://www.ebi.ac.uk/interpro/entry/IPR001953
InterPro	IPR004709	http://www.ebi.ac.uk/interpro/entry/IPR004709
InterPro	IPR006153	http://www.ebi.ac.uk/interpro/entry/IPR006153
InterPro	IPR018422	http://www.ebi.ac.uk/interpro/entry/IPR018422
InterPro	IPR032103	http://www.ebi.ac.uk/interpro/entry/IPR032103
Jabion	389015	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=389015
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:389015	http://www.genome.jp/dbget-bin/www_bget?hsa:389015
KEGG_Orthology	KO:K13961	http://www.genome.jp/dbget-bin/www_bget?KO:K13961
KEGG_Pathway	ko04971	http://www.genome.jp/kegg-bin/show_pathway?ko04971
MIM	600531	http://www.ncbi.nlm.nih.gov/omim/600531
OMA	LAFCQIW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LAFCQIW
OrthoDB	EOG091G02Q0	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02Q0
PANTHER	PTHR10110	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10110
PRINTS	PR01084	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01084
PRINTS	PR01086	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01086
PSORT	swissprot:SL9A4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SL9A4_HUMAN
PSORT-B	swissprot:SL9A4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SL9A4_HUMAN
PSORT2	swissprot:SL9A4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SL9A4_HUMAN
Pfam	PF00999	http://pfam.xfam.org/family/PF00999
Pfam	PF16644	http://pfam.xfam.org/family/PF16644
PharmGKB	PA35933	http://www.pharmgkb.org/do/serve?objId=PA35933&objCls=Gene
Phobius	swissprot:SL9A4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SL9A4_HUMAN
PhylomeDB	Q6AI14	http://phylomedb.org/?seqid=Q6AI14
ProteinModelPortal	Q6AI14	http://www.proteinmodelportal.org/query/uniprot/Q6AI14
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
Reactome	R-HSA-425986	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425986
RefSeq	NP_001011552	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001011552
SMR	Q6AI14	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q6AI14
STRING	9606.ENSP00000295269	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000295269&targetmode=cogs
TCDB	2.A.36.1.18	http://www.tcdb.org/search/result.php?tc=2.A.36.1.18
TIGRFAMs	TIGR00840	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00840
UCSC	uc002tbz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002tbz&org=rat
UniGene	Hs.447686	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.447686
UniProtKB	SL9A4_HUMAN	http://www.uniprot.org/uniprot/SL9A4_HUMAN
UniProtKB-AC	Q6AI14	http://www.uniprot.org/uniprot/Q6AI14
charge	swissprot:SL9A4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SL9A4_HUMAN
eggNOG	COG0025	http://eggnogapi.embl.de/nog_data/html/tree/COG0025
eggNOG	KOG1966	http://eggnogapi.embl.de/nog_data/html/tree/KOG1966
epestfind	swissprot:SL9A4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SL9A4_HUMAN
garnier	swissprot:SL9A4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SL9A4_HUMAN
helixturnhelix	swissprot:SL9A4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SL9A4_HUMAN
hmoment	swissprot:SL9A4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SL9A4_HUMAN
iep	swissprot:SL9A4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SL9A4_HUMAN
inforesidue	swissprot:SL9A4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SL9A4_HUMAN
neXtProt	NX_Q6AI14	http://www.nextprot.org/db/entry/NX_Q6AI14
octanol	swissprot:SL9A4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SL9A4_HUMAN
pepcoil	swissprot:SL9A4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SL9A4_HUMAN
pepdigest	swissprot:SL9A4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SL9A4_HUMAN
pepinfo	swissprot:SL9A4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SL9A4_HUMAN
pepnet	swissprot:SL9A4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SL9A4_HUMAN
pepstats	swissprot:SL9A4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SL9A4_HUMAN
pepwheel	swissprot:SL9A4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SL9A4_HUMAN
pepwindow	swissprot:SL9A4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SL9A4_HUMAN
sigcleave	swissprot:SL9A4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SL9A4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S12A1_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=A; IsoId=Q13621-1; Sequence=Displayed; Name=B; IsoId=Q13621-2; Sequence=Not described; Name=F; IsoId=Q13621-3; Sequence=VSP_035701; Note=Ref.1 (AAB07364) sequence is in conflict in positions  220 VV->TI. Ref.1 (AAB07364) sequence is in conflict in position  225 L->I. Ref.1 (AAB07364) sequence is in conflict in position  228 I->M. Ref.1 (AAB07364) sequence is in conflict in position  230 M->T. Ref.1 (AAB07364) sequence is in conflict in position  234 C->A.; 
# AltName	S12A1_HUMAN	Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2
# AltName	S12A1_HUMAN	Kidney-specific Na-K-Cl symporter
# CCDS	CCDS10129	-. [Q13621-1]
# CCDS	CCDS53940	-. [Q13621-3]
# ChiTaRS	SLC12A1	human
# DISEASE	S12A1_HUMAN	Bartter syndrome 1, antenatal (BARTS1) [MIM 601678]  A form of Bartter syndrome, an autosomal recessive disorder characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BARTS1 is a life-threatening condition beginning in utero, with marked fetal polyuria that leads to polyhydramnios and premature delivery. Another hallmark is a marked hypercalciuria and, as a secondary consequence, the development of nephrocalcinosis and osteopenia. {ECO 0000269|PubMed 8640224}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00214	Torasemide
# DrugBank	DB00232	Methyclothiazide
# DrugBank	DB00310	Chlorthalidone
# DrugBank	DB00534	Chlormerodrin
# DrugBank	DB00695	Furosemide
# DrugBank	DB00761	Potassium Chloride
# DrugBank	DB00774	Hydroflumethiazide
# DrugBank	DB00887	Bumetanide
# DrugBank	DB00903	Ethacrynic acid
# DrugBank	DB01021	Trichlormethiazide
# DrugBank	DB01325	Quinethazone
# ENZYME REGULATION	Activated by WNK3. {ECO:0000269|PubMed	21613606}. 
# Ensembl	ENST00000380993	ENSP00000370381; ENSG00000074803. [Q13621-1]
# Ensembl	ENST00000396577	ENSP00000379822; ENSG00000074803. [Q13621-3]
# Ensembl	ENST00000558405	ENSP00000453409; ENSG00000074803. [Q13621-1]
# ExpressionAtlas	Q13621	baseline and differential
# FUNCTION	S12A1_HUMAN	Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0016324	apical plasma membrane; IBA:GO_Central.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	S12A1_HUMAN	GO 0008511 sodium potassium chloride symporter activity; TAS Reactome.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006813	potassium ion transport; IEA:UniProtKB-KW.
# GO_process	GO:0006814	sodium ion transport; IEA:UniProtKB-KW.
# GO_process	GO:0034220	ion transmembrane transport; ISS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q13621	HS
# HGNC	HGNC:10910	SLC12A1
# IntAct	Q13621	3
# InterPro	IPR002443	Na/K/Cl_cotranspt
# InterPro	IPR002445	Slc12a1
# InterPro	IPR004841	AA-permease/SLC12A_dom
# InterPro	IPR004842	SLC12A_fam
# InterPro	IPR013612	AA_permease_N
# InterPro	IPR018491	SLC12_C
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H00239	[Endocrine disease; Urinary system disease] Bartter syndrome
# MIM	600839	gene
# MIM	601678	phenotype
# Organism	S12A1_HUMAN	Homo sapiens (Human)
# Orphanet	93604	Antenatal Bartter syndrome
# PANTHER	PTHR11827:SF45	PTHR11827:SF45; 3
# PRINTS	PR01207	NAKCLTRNSPRT
# PRINTS	PR01209	NAKCLTRSPRT2
# Pfam	PF00324	AA_permease
# Pfam	PF03522	SLC12
# Pfam	PF08403	AA_permease_N
# Proteomes	UP000005640	Chromosome 15
# Reactome	R-HSA-426117	Cation-coupled Chloride cotransporters
# RecName	S12A1_HUMAN	Solute carrier family 12 member 1
# RefSeq	NP_000329	NM_000338.2. [Q13621-1]
# RefSeq	NP_001171761	NM_001184832.1. [Q13621-3]
# SIMILARITY	Belongs to the SLC12A transporter family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S12A1_HUMAN	Membrane; Multi-pass membrane protein. 
# TCDB	2.A.30.1	the cation-chloride cotransporter (ccc) family
# TIGRFAMs	TIGR00930	2a30
# TISSUE SPECIFICITY	S12A1_HUMAN	Kidney specific. 
# UCSC	uc001zwn	human. [Q13621-1]
# eggNOG	COG0531	LUCA
# eggNOG	KOG2083	Eukaryota
BLAST	swissprot:S12A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S12A1_HUMAN
BioCyc	ZFISH:ENSG00000074803-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000074803-MONOMER
COXPRESdb	6557	http://coxpresdb.jp/data/gene/6557.shtml
CleanEx	HS_SLC12A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC12A1
DOI	10.1038/nature04601	http://dx.doi.org/10.1038/nature04601
DOI	10.1038/ng0696-183	http://dx.doi.org/10.1038/ng0696-183
DOI	10.1152/ajpcell.00070.2011	http://dx.doi.org/10.1152/ajpcell.00070.2011
DrugBank	DB00214	http://www.drugbank.ca/drugs/DB00214
DrugBank	DB00232	http://www.drugbank.ca/drugs/DB00232
DrugBank	DB00310	http://www.drugbank.ca/drugs/DB00310
DrugBank	DB00534	http://www.drugbank.ca/drugs/DB00534
DrugBank	DB00695	http://www.drugbank.ca/drugs/DB00695
DrugBank	DB00761	http://www.drugbank.ca/drugs/DB00761
DrugBank	DB00774	http://www.drugbank.ca/drugs/DB00774
DrugBank	DB00887	http://www.drugbank.ca/drugs/DB00887
DrugBank	DB00903	http://www.drugbank.ca/drugs/DB00903
DrugBank	DB01021	http://www.drugbank.ca/drugs/DB01021
DrugBank	DB01325	http://www.drugbank.ca/drugs/DB01325
EMBL	AC023355	http://www.ebi.ac.uk/ena/data/view/AC023355
EMBL	AC066612	http://www.ebi.ac.uk/ena/data/view/AC066612
EMBL	EF559316	http://www.ebi.ac.uk/ena/data/view/EF559316
EMBL	U58130	http://www.ebi.ac.uk/ena/data/view/U58130
Ensembl	ENST00000380993	http://www.ensembl.org/id/ENST00000380993
Ensembl	ENST00000396577	http://www.ensembl.org/id/ENST00000396577
Ensembl	ENST00000558405	http://www.ensembl.org/id/ENST00000558405
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0008511	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008511
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC12A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC12A1
GeneID	6557	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6557
GeneTree	ENSGT00760000119053	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119053
H-InvDB	HIX0026769	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0026769
HGNC	HGNC:10910	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10910
HOGENOM	HOG000062855	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000062855&db=HOGENOM6
HOVERGEN	HBG052851	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052851&db=HOVERGEN
HPA	HPA014967	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014967
HPA	HPA018107	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA018107
InParanoid	Q13621	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q13621
IntAct	Q13621	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q13621*
InterPro	IPR002443	http://www.ebi.ac.uk/interpro/entry/IPR002443
InterPro	IPR002445	http://www.ebi.ac.uk/interpro/entry/IPR002445
InterPro	IPR004841	http://www.ebi.ac.uk/interpro/entry/IPR004841
InterPro	IPR004842	http://www.ebi.ac.uk/interpro/entry/IPR004842
InterPro	IPR013612	http://www.ebi.ac.uk/interpro/entry/IPR013612
InterPro	IPR018491	http://www.ebi.ac.uk/interpro/entry/IPR018491
Jabion	6557	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6557
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00239	http://www.genome.jp/dbget-bin/www_bget?H00239
KEGG_Gene	hsa:6557	http://www.genome.jp/dbget-bin/www_bget?hsa:6557
KEGG_Orthology	KO:K14425	http://www.genome.jp/dbget-bin/www_bget?KO:K14425
MIM	600839	http://www.ncbi.nlm.nih.gov/omim/600839
MIM	601678	http://www.ncbi.nlm.nih.gov/omim/601678
OMA	CVKEMNS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CVKEMNS
Orphanet	93604	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=93604
OrthoDB	EOG091G04G2	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G04G2
PANTHER	PTHR11827:SF45	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11827:SF45
PRINTS	PR01207	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01207
PRINTS	PR01209	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01209
PSORT	swissprot:S12A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S12A1_HUMAN
PSORT-B	swissprot:S12A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S12A1_HUMAN
PSORT2	swissprot:S12A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S12A1_HUMAN
Pfam	PF00324	http://pfam.xfam.org/family/PF00324
Pfam	PF03522	http://pfam.xfam.org/family/PF03522
Pfam	PF08403	http://pfam.xfam.org/family/PF08403
PharmGKB	PA320	http://www.pharmgkb.org/do/serve?objId=PA320&objCls=Gene
Phobius	swissprot:S12A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S12A1_HUMAN
PhylomeDB	Q13621	http://phylomedb.org/?seqid=Q13621
ProteinModelPortal	Q13621	http://www.proteinmodelportal.org/query/uniprot/Q13621
PubMed	16572171	http://www.ncbi.nlm.nih.gov/pubmed/16572171
PubMed	21613606	http://www.ncbi.nlm.nih.gov/pubmed/21613606
PubMed	8640224	http://www.ncbi.nlm.nih.gov/pubmed/8640224
Reactome	R-HSA-426117	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-426117
RefSeq	NP_000329	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000329
RefSeq	NP_001171761	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001171761
STRING	9606.ENSP00000370381	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000370381&targetmode=cogs
TCDB	2.A.30.1	http://www.tcdb.org/search/result.php?tc=2.A.30.1
TIGRFAMs	TIGR00930	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00930
UCSC	uc001zwn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001zwn&org=rat
UniGene	Hs.123116	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.123116
UniGene	Hs.605373	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.605373
UniProtKB	S12A1_HUMAN	http://www.uniprot.org/uniprot/S12A1_HUMAN
UniProtKB-AC	Q13621	http://www.uniprot.org/uniprot/Q13621
charge	swissprot:S12A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S12A1_HUMAN
eggNOG	COG0531	http://eggnogapi.embl.de/nog_data/html/tree/COG0531
eggNOG	KOG2083	http://eggnogapi.embl.de/nog_data/html/tree/KOG2083
epestfind	swissprot:S12A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S12A1_HUMAN
garnier	swissprot:S12A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S12A1_HUMAN
helixturnhelix	swissprot:S12A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S12A1_HUMAN
hmoment	swissprot:S12A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S12A1_HUMAN
iep	swissprot:S12A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S12A1_HUMAN
inforesidue	swissprot:S12A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S12A1_HUMAN
neXtProt	NX_Q13621	http://www.nextprot.org/db/entry/NX_Q13621
octanol	swissprot:S12A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S12A1_HUMAN
pepcoil	swissprot:S12A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S12A1_HUMAN
pepdigest	swissprot:S12A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S12A1_HUMAN
pepinfo	swissprot:S12A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S12A1_HUMAN
pepnet	swissprot:S12A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S12A1_HUMAN
pepstats	swissprot:S12A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S12A1_HUMAN
pepwheel	swissprot:S12A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S12A1_HUMAN
pepwindow	swissprot:S12A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S12A1_HUMAN
sigcleave	swissprot:S12A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S12A1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TNPO2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O14787-1; Sequence=Displayed; Name=2; Synonyms=beta2b; IsoId=O14787-2; Sequence=VSP_009657; Note=No experimental confirmation available.; 
# AltName	TNPO2_HUMAN	Karyopherin beta-2b
# BioGrid	119024	62
# CCDS	CCDS45991	-. [O14787-1]
# CCDS	CCDS45992	-. [O14787-2]
# ChiTaRS	TNPO2	human
# Ensembl	ENST00000356861	ENSP00000349321; ENSG00000105576. [O14787-2]
# Ensembl	ENST00000425528	ENSP00000407182; ENSG00000105576. [O14787-1]
# Ensembl	ENST00000450764	ENSP00000397379; ENSG00000105576. [O14787-2]
# Ensembl	ENST00000588216	ENSP00000465625; ENSG00000105576. [O14787-2]
# Ensembl	ENST00000592287	ENSP00000468434; ENSG00000105576. [O14787-1]
# ExpressionAtlas	O14787	baseline and differential
# FUNCTION	TNPO2_HUMAN	Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). {ECO 0000250}. 
# GO_component	GO:0005634	nucleus; TAS:ProtInc.
# GO_component	GO:0005737	cytoplasm; TAS:ProtInc.
# GO_component	GO:0031965	nuclear membrane; IBA:GO_Central.
# GO_component	GO:0034399	nuclear periphery; IBA:GO_Central.
# GO_function	GO:0008139	nuclear localization sequence binding; TAS:ProtInc.
# GO_function	GO:0008565	protein transporter activity; IBA:GO_Central.
# GO_process	GO:0000059	protein import into nucleus, docking; IBA:GO_Central.
# GO_process	GO:0000060	protein import into nucleus, translocation; IBA:GO_Central.
# GO_process	GO:0006607	NLS-bearing protein import into nucleus; IBA:GO_Central.
# GO_process	GO:0006610	ribosomal protein import into nucleus; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005737	cytoplasm
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# Gene3D	1.25.10.10	-; 2.
# Genevisible	O14787	HS
# HGNC	HGNC:19998	TNPO2
# INTERACTION	TNPO2_HUMAN	Q96GX9 APIP; NbExp=3; IntAct=EBI-431907, EBI-359248; Q6P1W5 C1orf94; NbExp=3; IntAct=EBI-431907, EBI-946029; Q13557 CAMK2D; NbExp=3; IntAct=EBI-431907, EBI-351018; Q8IW24 EXOC5; NbExp=3; IntAct=EBI-431907, EBI-10171392; V9HW27 HEL-S-101; NbExp=3; IntAct=EBI-431907, EBI-10178933; O95198 KLHL2; NbExp=3; IntAct=EBI-431907, EBI-746999; P15531 NME1; NbExp=3; IntAct=EBI-431907, EBI-741141; Q96PV4 PNMA5; NbExp=3; IntAct=EBI-431907, EBI-10171633; P54274 TERF1; NbExp=2; IntAct=EBI-431907, EBI-710997; 
# IntAct	O14787	19
# InterPro	IPR001494	Importin-beta_N
# InterPro	IPR011989	ARM-like
# InterPro	IPR016024	ARM-type_fold
# MIM	603002	gene
# Organism	TNPO2_HUMAN	Homo sapiens (Human)
# Pfam	PF03810	IBN_N
# Proteomes	UP000005640	Chromosome 19
# RecName	TNPO2_HUMAN	Transportin-2
# RefSeq	NP_001129667	NM_001136195.1. [O14787-2]
# RefSeq	NP_001129668	NM_001136196.1. [O14787-1]
# RefSeq	NP_038461	NM_013433.4. [O14787-2]
# SIMILARITY	Belongs to the importin beta family. Importin beta-2 subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 importin N-terminal domain. {ECO	0000305}.
# SIMILARITY	Contains 20 HEAT repeats. {ECO:0000250|UniProtKB	Q92973}. 
# SMART	SM00913	IBN_N
# SUBCELLULAR LOCATION	TNPO2_HUMAN	Cytoplasm {ECO 0000250}. Nucleus {ECO 0000250}. 
# SUPFAM	SSF48371	SSF48371
# TCDB	1.I.1.1	the nuclear pore complex (npc) family
# UCSC	uc002muo	human. [O14787-1]
# eggNOG	ENOG410XPK2	LUCA
# eggNOG	KOG2023	Eukaryota
BLAST	swissprot:TNPO2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TNPO2_HUMAN
BioCyc	ZFISH:ENSG00000105576-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000105576-MONOMER
COXPRESdb	30000	http://coxpresdb.jp/data/gene/30000.shtml
CleanEx	HS_TNPO2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TNPO2
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DOI	10.1056/NEJMoa1206524	http://dx.doi.org/10.1056/NEJMoa1206524
DOI	10.1083/jcb.138.6.1181	http://dx.doi.org/10.1083/jcb.138.6.1181
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AC018761	http://www.ebi.ac.uk/ena/data/view/AC018761
EMBL	AF007748	http://www.ebi.ac.uk/ena/data/view/AF007748
EMBL	AF019039	http://www.ebi.ac.uk/ena/data/view/AF019039
EMBL	BC072420	http://www.ebi.ac.uk/ena/data/view/BC072420
EMBL	CH471106	http://www.ebi.ac.uk/ena/data/view/CH471106
Ensembl	ENST00000356861	http://www.ensembl.org/id/ENST00000356861
Ensembl	ENST00000425528	http://www.ensembl.org/id/ENST00000425528
Ensembl	ENST00000450764	http://www.ensembl.org/id/ENST00000450764
Ensembl	ENST00000588216	http://www.ensembl.org/id/ENST00000588216
Ensembl	ENST00000592287	http://www.ensembl.org/id/ENST00000592287
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0031965	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031965
GO_component	GO:0034399	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034399
GO_function	GO:0008139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008139
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0000059	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000059
GO_process	GO:0000060	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000060
GO_process	GO:0006607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006607
GO_process	GO:0006610	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006610
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
GeneCards	TNPO2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TNPO2
GeneID	30000	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=30000
GeneTree	ENSGT00550000074720	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074720
HGNC	HGNC:19998	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:19998
HOGENOM	HOG000203940	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000203940&db=HOGENOM6
HOVERGEN	HBG058963	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG058963&db=HOVERGEN
HPA	CAB046446	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB046446
InParanoid	O14787	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O14787
IntAct	O14787	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O14787*
InterPro	IPR001494	http://www.ebi.ac.uk/interpro/entry/IPR001494
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
Jabion	30000	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=30000
KEGG_Gene	hsa:30000	http://www.genome.jp/dbget-bin/www_bget?hsa:30000
MIM	603002	http://www.ncbi.nlm.nih.gov/omim/603002
MINT	MINT-2998321	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-2998321
OMA	CAMDWQP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CAMDWQP
OrthoDB	EOG091G01O2	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01O2
PSORT	swissprot:TNPO2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TNPO2_HUMAN
PSORT-B	swissprot:TNPO2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TNPO2_HUMAN
PSORT2	swissprot:TNPO2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TNPO2_HUMAN
Pfam	PF03810	http://pfam.xfam.org/family/PF03810
PharmGKB	PA134921349	http://www.pharmgkb.org/do/serve?objId=PA134921349&objCls=Gene
Phobius	swissprot:TNPO2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TNPO2_HUMAN
PhylomeDB	O14787	http://phylomedb.org/?seqid=O14787
ProteinModelPortal	O14787	http://www.proteinmodelportal.org/query/uniprot/O14787
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23033978	http://www.ncbi.nlm.nih.gov/pubmed/23033978
PubMed	9298975	http://www.ncbi.nlm.nih.gov/pubmed/9298975
RefSeq	NP_001129667	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001129667
RefSeq	NP_001129668	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001129668
RefSeq	NP_038461	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_038461
SMART	SM00913	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00913
SMR	O14787	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O14787
STRING	9606.ENSP00000407182	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000407182&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
TCDB	1.I.1.1	http://www.tcdb.org/search/result.php?tc=1.I.1.1
UCSC	uc002muo	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002muo&org=rat
UniGene	Hs.416049	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.416049
UniGene	Hs.714402	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.714402
UniProtKB	TNPO2_HUMAN	http://www.uniprot.org/uniprot/TNPO2_HUMAN
UniProtKB-AC	O14787	http://www.uniprot.org/uniprot/O14787
charge	swissprot:TNPO2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TNPO2_HUMAN
eggNOG	ENOG410XPK2	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPK2
eggNOG	KOG2023	http://eggnogapi.embl.de/nog_data/html/tree/KOG2023
epestfind	swissprot:TNPO2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TNPO2_HUMAN
garnier	swissprot:TNPO2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TNPO2_HUMAN
helixturnhelix	swissprot:TNPO2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TNPO2_HUMAN
hmoment	swissprot:TNPO2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TNPO2_HUMAN
iep	swissprot:TNPO2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TNPO2_HUMAN
inforesidue	swissprot:TNPO2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TNPO2_HUMAN
neXtProt	NX_O14787	http://www.nextprot.org/db/entry/NX_O14787
octanol	swissprot:TNPO2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TNPO2_HUMAN
pepcoil	swissprot:TNPO2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TNPO2_HUMAN
pepdigest	swissprot:TNPO2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TNPO2_HUMAN
pepinfo	swissprot:TNPO2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TNPO2_HUMAN
pepnet	swissprot:TNPO2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TNPO2_HUMAN
pepstats	swissprot:TNPO2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TNPO2_HUMAN
pepwheel	swissprot:TNPO2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TNPO2_HUMAN
pepwindow	swissprot:TNPO2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TNPO2_HUMAN
sigcleave	swissprot:TNPO2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TNPO2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	DEN5A_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6IQ26-1; Sequence=Displayed; Name=2; IsoId=Q6IQ26-2; Sequence=VSP_044688; Note=No experimental confirmation available.; 
# AltName	DEN5A_HUMAN	Rab6-interacting protein 1
# BioGrid	116861	5
# CCDS	CCDS31423	-. [Q6IQ26-1]
# CCDS	CCDS58119	-. [Q6IQ26-2]
# ChiTaRS	DENND5A	human
# Ensembl	ENST00000328194	ENSP00000328524; ENSG00000184014. [Q6IQ26-1]
# Ensembl	ENST00000530044	ENSP00000435866; ENSG00000184014. [Q6IQ26-2]
# ExpressionAtlas	Q6IQ26	baseline and differential
# FUNCTION	DEN5A_HUMAN	Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO 0000269|PubMed 20937701}. 
# GO_component	GO:0005802	trans-Golgi network; IDA:UniProtKB.
# GO_component	GO:0005829	cytosol; IEA:GOC.
# GO_function	GO:0005262	calcium channel activity; IBA:GO_Central.
# GO_function	GO:0017112	Rab guanyl-nucleotide exchange factor activity; IDA:UniProtKB.
# GO_process	GO:0042147	retrograde transport, endosome to Golgi; IMP:UniProtKB.
# GO_process	GO:0050982	detection of mechanical stimulus; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005829	cytosol
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# Gene3D	2.60.60.20	-; 1.
# Genevisible	Q6IQ26	HS
# HGNC	HGNC:19344	DENND5A
# IntAct	Q6IQ26	4
# InterPro	IPR001024	PLAT/LH2_dom
# InterPro	IPR001194	DENN_dom
# InterPro	IPR004012	Run_dom
# InterPro	IPR005112	dDENN_dom
# InterPro	IPR005113	uDENN_dom
# Organism	DEN5A_HUMAN	Homo sapiens (Human)
# PIR	T17242	T17242
# PROSITE	PS50095	PLAT
# PROSITE	PS50211	DENN
# PROSITE	PS50826	RUN; 2
# PROSITE	PS50946	UDENN
# PROSITE	PS50947	DDENN
# Pfam	PF01477	PLAT
# Pfam	PF02141	DENN
# Pfam	PF02759	RUN; 2
# Pfam	PF03455	dDENN
# Pfam	PF03456	uDENN
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-8876198	RAB GEFs exchange GTP for GDP on RABs
# RecName	DEN5A_HUMAN	DENN domain-containing protein 5A
# RefSeq	NP_001230183	NM_001243254.1. [Q6IQ26-2]
# RefSeq	NP_056028	NM_015213.3. [Q6IQ26-1]
# SEQUENCE CAUTION	Sequence=BAA83043.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB15155.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the RAB6IP1 family. {ECO	0000305}. 
# SIMILARITY	Contains 1 DENN domain. {ECO:0000255|PROSITE- ProRule	PRU00304}. 
# SIMILARITY	Contains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule	PRU00152}. 
# SIMILARITY	Contains 1 dDENN domain. {ECO:0000255|PROSITE- ProRule	PRU00306}. 
# SIMILARITY	Contains 1 uDENN domain. {ECO:0000255|PROSITE- ProRule	PRU00305}. 
# SIMILARITY	Contains 2 RUN domains. {ECO:0000255|PROSITE- ProRule	PRU00178}. 
# SMART	SM00593	RUN; 2
# SMART	SM00799	DENN
# SMART	SM00800	uDENN
# SMART	SM00801	dDENN
# SUBUNIT	Probably interacts with RAB6A bound to GTP. {ECO	0000250}. 
# SUPFAM	SSF49723	SSF49723
# UCSC	uc001mhl	human. [Q6IQ26-1]
# eggNOG	ENOG410XNYP	LUCA
# eggNOG	KOG2080	Eukaryota
BLAST	swissprot:DEN5A_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:DEN5A_HUMAN
BioCyc	ZFISH:G66-32644-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32644-MONOMER
COXPRESdb	23258	http://coxpresdb.jp/data/gene/23258.shtml
CleanEx	HS_DENND5A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_DENND5A
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1083/jcb.201008051	http://dx.doi.org/10.1083/jcb.201008051
DOI	10.1093/dnares/6.3.197	http://dx.doi.org/10.1093/dnares/6.3.197
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AB029014	http://www.ebi.ac.uk/ena/data/view/AB029014
EMBL	AC055845	http://www.ebi.ac.uk/ena/data/view/AC055845
EMBL	AC079296	http://www.ebi.ac.uk/ena/data/view/AC079296
EMBL	AK025499	http://www.ebi.ac.uk/ena/data/view/AK025499
EMBL	AK295881	http://www.ebi.ac.uk/ena/data/view/AK295881
EMBL	AL117448	http://www.ebi.ac.uk/ena/data/view/AL117448
EMBL	AP006259	http://www.ebi.ac.uk/ena/data/view/AP006259
EMBL	BC009354	http://www.ebi.ac.uk/ena/data/view/BC009354
EMBL	BC071596	http://www.ebi.ac.uk/ena/data/view/BC071596
Ensembl	ENST00000328194	http://www.ensembl.org/id/ENST00000328194
Ensembl	ENST00000530044	http://www.ensembl.org/id/ENST00000530044
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005802	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005802
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0017112	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017112
GO_process	GO:0042147	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042147
GO_process	GO:0050982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050982
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
Gene3D	2.60.60.20	http://www.cathdb.info/version/latest/superfamily/2.60.60.20
GeneCards	DENND5A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=DENND5A
GeneID	23258	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23258
GeneTree	ENSGT00760000118819	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118819
H-InvDB	HIX0009434	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0009434
HGNC	HGNC:19344	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:19344
HOGENOM	HOG000019389	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000019389&db=HOGENOM6
HOVERGEN	HBG059906	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG059906&db=HOVERGEN
HPA	HPA052923	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA052923
HPA	HPA055009	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA055009
InParanoid	Q6IQ26	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6IQ26
IntAct	Q6IQ26	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q6IQ26*
InterPro	IPR001024	http://www.ebi.ac.uk/interpro/entry/IPR001024
InterPro	IPR001194	http://www.ebi.ac.uk/interpro/entry/IPR001194
InterPro	IPR004012	http://www.ebi.ac.uk/interpro/entry/IPR004012
InterPro	IPR005112	http://www.ebi.ac.uk/interpro/entry/IPR005112
InterPro	IPR005113	http://www.ebi.ac.uk/interpro/entry/IPR005113
Jabion	23258	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=23258
KEGG_Gene	hsa:23258	http://www.genome.jp/dbget-bin/www_bget?hsa:23258
MINT	MINT-8247429	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8247429
OMA	AKWLVEC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AKWLVEC
OrthoDB	EOG091G00VU	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00VU
PROSITE	PS50095	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50095
PROSITE	PS50211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50211
PROSITE	PS50826	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50826
PROSITE	PS50946	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50946
PROSITE	PS50947	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50947
PSORT	swissprot:DEN5A_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:DEN5A_HUMAN
PSORT-B	swissprot:DEN5A_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:DEN5A_HUMAN
PSORT2	swissprot:DEN5A_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:DEN5A_HUMAN
Pfam	PF01477	http://pfam.xfam.org/family/PF01477
Pfam	PF02141	http://pfam.xfam.org/family/PF02141
Pfam	PF02759	http://pfam.xfam.org/family/PF02759
Pfam	PF03455	http://pfam.xfam.org/family/PF03455
Pfam	PF03456	http://pfam.xfam.org/family/PF03456
PharmGKB	PA164718737	http://www.pharmgkb.org/do/serve?objId=PA164718737&objCls=Gene
Phobius	swissprot:DEN5A_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:DEN5A_HUMAN
PhylomeDB	Q6IQ26	http://phylomedb.org/?seqid=Q6IQ26
ProteinModelPortal	Q6IQ26	http://www.proteinmodelportal.org/query/uniprot/Q6IQ26
PubMed	10470851	http://www.ncbi.nlm.nih.gov/pubmed/10470851
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	20937701	http://www.ncbi.nlm.nih.gov/pubmed/20937701
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
Reactome	R-HSA-8876198	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8876198
RefSeq	NP_001230183	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001230183
RefSeq	NP_056028	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_056028
SMART	SM00593	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00593
SMART	SM00799	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00799
SMART	SM00800	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00800
SMART	SM00801	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00801
SMR	Q6IQ26	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q6IQ26
STRING	9606.ENSP00000328524	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000328524&targetmode=cogs
SUPFAM	SSF49723	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49723
UCSC	uc001mhl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001mhl&org=rat
UniGene	Hs.501857	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.501857
UniProtKB	DEN5A_HUMAN	http://www.uniprot.org/uniprot/DEN5A_HUMAN
UniProtKB-AC	Q6IQ26	http://www.uniprot.org/uniprot/Q6IQ26
charge	swissprot:DEN5A_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:DEN5A_HUMAN
eggNOG	ENOG410XNYP	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNYP
eggNOG	KOG2080	http://eggnogapi.embl.de/nog_data/html/tree/KOG2080
epestfind	swissprot:DEN5A_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:DEN5A_HUMAN
garnier	swissprot:DEN5A_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:DEN5A_HUMAN
helixturnhelix	swissprot:DEN5A_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:DEN5A_HUMAN
hmoment	swissprot:DEN5A_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:DEN5A_HUMAN
iep	swissprot:DEN5A_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:DEN5A_HUMAN
inforesidue	swissprot:DEN5A_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:DEN5A_HUMAN
neXtProt	NX_Q6IQ26	http://www.nextprot.org/db/entry/NX_Q6IQ26
octanol	swissprot:DEN5A_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:DEN5A_HUMAN
pepcoil	swissprot:DEN5A_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:DEN5A_HUMAN
pepdigest	swissprot:DEN5A_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:DEN5A_HUMAN
pepinfo	swissprot:DEN5A_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:DEN5A_HUMAN
pepnet	swissprot:DEN5A_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:DEN5A_HUMAN
pepstats	swissprot:DEN5A_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:DEN5A_HUMAN
pepwheel	swissprot:DEN5A_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:DEN5A_HUMAN
pepwindow	swissprot:DEN5A_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:DEN5A_HUMAN
sigcleave	swissprot:DEN5A_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:DEN5A_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	PDE2A_HUMAN	Event=Alternative splicing; Named isoforms=6; Comment=Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms.; Name=PDE2A3; IsoId=O00408-1; Sequence=Displayed; Name=PDE2A1; IsoId=O00408-2; Sequence=VSP_055315; Note=Soluble form.; Name=PDE2A2; IsoId=O00408-3; Sequence=VSP_055316; Note=Contains a transit peptide at positions 1-17.; Name=PDE2A4; IsoId=O00408-4; Sequence=VSP_055317; Name=5; IsoId=O00408-5; Sequence=VSP_055316, VSP_055318; Note=No experimental confirmation available.; Name=6; IsoId=O00408-6; Sequence=VSP_055315, VSP_055319, VSP_055320; Note=No experimental confirmation available.; 
# AltName	PDE2A_HUMAN	Cyclic GMP-stimulated phosphodiesterase
# BRENDA	3.1.4.17	2681
# BioGrid	111164	3
# CATALYTIC ACTIVITY	PDE2A_HUMAN	Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate. 
# CCDS	CCDS44670	-. [O00408-3]
# CCDS	CCDS53678	-. [O00408-4]
# CCDS	CCDS73345	-. [O00408-2]
# CCDS	CCDS8216	-. [O00408-1]
# COFACTOR	PDE2A_HUMAN	Name=a divalent metal cation; Xref=ChEBI CHEBI 60240; Evidence={ECO 0000250}; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. {ECO 0000250}; 
# ChiTaRS	PDE2A	human
# DOMAIN	PDE2A_HUMAN	GAF 1 functions as a dimerization domain, whereas GAF 2 binds cGMP, which causes activation of the catalytic activity of the enzyme. {ECO 0000250}. 
# DrugBank	DB00201	Caffeine
# DrugBank	DB08811	Tofisopam
# Ensembl	ENST00000334456	ENSP00000334910; ENSG00000186642. [O00408-1]
# Ensembl	ENST00000376450	ENSP00000365633; ENSG00000186642. [O00408-5]
# Ensembl	ENST00000444035	ENSP00000411657; ENSG00000186642. [O00408-2]
# Ensembl	ENST00000540345	ENSP00000446399; ENSG00000186642. [O00408-4]
# Ensembl	ENST00000544570	ENSP00000442256; ENSG00000186642. [O00408-3]
# ExpressionAtlas	O00408	baseline and differential
# FUNCTION	PDE2A_HUMAN	Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. 
# FUNCTION	PDE2A_HUMAN	Isoform PDE2A2  Regulates Mitochondrial cAMP Levels and Respiration. 
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005759	mitochondrial matrix; ISS:UniProtKB.
# GO_component	GO:0005783	endoplasmic reticulum; ISS:UniProtKB.
# GO_component	GO:0005794	Golgi apparatus; ISS:UniProtKB.
# GO_component	GO:0005829	cytosol; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0042734	presynaptic membrane; ISS:UniProtKB.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IDA:UniProtKB.
# GO_function	GO:0004112	cyclic-nucleotide phosphodiesterase activity; IDA:UniProtKB.
# GO_function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity; TAS:Reactome.
# GO_function	GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; IDA:UniProtKB.
# GO_function	GO:0005262	calcium channel activity; TAS:UniProtKB.
# GO_function	GO:0008144	drug binding; IDA:UniProtKB.
# GO_function	GO:0030552	cAMP binding; IMP:UniProtKB.
# GO_function	GO:0030553	cGMP binding; IDA:UniProtKB.
# GO_function	GO:0030911	TPR domain binding; IPI:UniProtKB.
# GO_function	GO:0042803	protein homodimerization activity; IPI:UniProtKB.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_function	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity; TAS:Reactome.
# GO_process	GO:0000122	negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
# GO_process	GO:0006198	cAMP catabolic process; IDA:UniProtKB.
# GO_process	GO:0006626	protein targeting to mitochondrion; ISS:UniProtKB.
# GO_process	GO:0008152	metabolic process; IDA:UniProtKB.
# GO_process	GO:0019933	cAMP-mediated signaling; IMP:UniProtKB.
# GO_process	GO:0019934	cGMP-mediated signaling; IMP:UniProtKB.
# GO_process	GO:0030224	monocyte differentiation; IEP:UniProtKB.
# GO_process	GO:0030818	negative regulation of cAMP biosynthetic process; ISS:UniProtKB.
# GO_process	GO:0033159	negative regulation of protein import into nucleus, translocation; IDA:UniProtKB.
# GO_process	GO:0035690	cellular response to drug; IMP:UniProtKB.
# GO_process	GO:0036006	cellular response to macrophage colony-stimulating factor stimulus; IDA:UniProtKB.
# GO_process	GO:0043116	negative regulation of vascular permeability; IMP:UniProtKB.
# GO_process	GO:0043117	positive regulation of vascular permeability; IMP:UniProtKB.
# GO_process	GO:0046069	cGMP catabolic process; IDA:UniProtKB.
# GO_process	GO:0050729	positive regulation of inflammatory response; ISS:UniProtKB.
# GO_process	GO:0061028	establishment of endothelial barrier; ISS:UniProtKB.
# GO_process	GO:0071260	cellular response to mechanical stimulus; ISS:UniProtKB.
# GO_process	GO:0071321	cellular response to cGMP; IDA:UniProtKB.
# GO_process	GO:0071560	cellular response to transforming growth factor beta stimulus; IEP:UniProtKB.
# GO_process	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0003013	circulatory system process
# GOslim_process	GO:0006605	protein targeting
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0034655	nucleobase-containing compound catabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0048856	anatomical structure development
# Gene3D	1.10.1300.10	-; 1.
# Gene3D	3.30.450.40	-; 2.
# Genevisible	O00408	HS
# HGNC	HGNC:8777	PDE2A
# INTERACTION	PDE2A_HUMAN	O00170 AIP; NbExp=6; IntAct=EBI-1785967, EBI-704197; 
# IntAct	O00408	3
# InterPro	IPR002073	PDEase_catalytic_dom
# InterPro	IPR003018	GAF
# InterPro	IPR003607	HD/PDEase_dom
# InterPro	IPR023088	PDEase
# InterPro	IPR023174	PDEase_CS
# InterPro	IPR029016	GAF_dom-like
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00230	Purine metabolism
# KEGG_Pathway	ko05032	Morphine addiction
# MIM	602658	gene
# MISCELLANEOUS	cGMP binds at an allosteric activator site. {ECO	0000250}. 
# Organism	PDE2A_HUMAN	Homo sapiens (Human)
# PDB	1Z1L	X-ray; 1.70 A; A=578-919
# PDB	3IBJ	X-ray; 3.02 A; A/B=215-900
# PDB	3ITM	X-ray; 2.49 A; A/B/C/D=579-919
# PDB	3ITU	X-ray; 1.58 A; A/B/C/D=579-919
# PDB	4C1I	X-ray; 2.40 A; A/B/C/D=578-921
# PDB	4D08	X-ray; 1.90 A; A/B/C/D=578-921
# PDB	4D09	X-ray; 2.50 A; A/B/C/D=578-921
# PDB	4HTX	X-ray; 1.90 A; A/B/C/D=578-919
# PDB	4HTZ	X-ray; 2.00 A; A/B/C/D=578-919
# PDB	4JIB	X-ray; 1.72 A; A/B/C/D=579-919
# PRINTS	PR00387	PDIESTERASE1
# PROSITE	PS00126	PDEASE_I
# Pfam	PF00233	PDEase_I
# Pfam	PF01590	GAF
# Pfam	PF13185	GAF_2
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-418457	cGMP effects
# Reactome	R-HSA-418555	G alpha (s) signalling events
# RecName	PDE2A_HUMAN	cGMP-dependent 3',5'-cyclic phosphodiesterase
# RefSeq	NP_001137311	NM_001143839.3. [O00408-3]
# RefSeq	NP_001139681	NM_001146209.2. [O00408-4]
# RefSeq	NP_001230713	NM_001243784.1. [O00408-2]
# RefSeq	NP_002590	NM_002599.4. [O00408-1]
# SEQUENCE CAUTION	Sequence=AAS75515.1; Type=Frameshift; Positions=48; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 2 GAF domains. {ECO	0000305}. 
# SMART	SM00065	GAF; 2
# SMART	SM00471	HDc
# SUBCELLULAR LOCATION	PDE2A_HUMAN	Isoform 5  Mitochondrion {ECO 0000305}. 
# SUBCELLULAR LOCATION	PDE2A_HUMAN	Isoform PDE2A1  Cytoplasm {ECO 0000269|PubMed 19632989}. 
# SUBCELLULAR LOCATION	PDE2A_HUMAN	Isoform PDE2A2  Mitochondrion matrix {ECO 0000269|PubMed 21724846}. 
# SUBCELLULAR LOCATION	PDE2A_HUMAN	Isoform PDE2A3  Cell membrane {ECO 0000269|PubMed 19632989}; Lipid-anchor {ECO 0000269|PubMed 19632989}. 
# SUBUNIT	PDE2A_HUMAN	Homodimer. {ECO 0000269|PubMed 15938621, ECO 0000269|PubMed 19828435, ECO 0000269|PubMed 23899287}. 
# SUPFAM	SSF55781	SSF55781; 3
# TISSUE SPECIFICITY	PDE2A_HUMAN	Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas. 
# UCSC	uc001osn	human. [O00408-1]
# eggNOG	ENOG410XRI7	LUCA
# eggNOG	KOG3689	Eukaryota
BLAST	swissprot:PDE2A_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:PDE2A_HUMAN
BioCyc	ZFISH:HS10579-MONOMER	http://biocyc.org/getid?id=ZFISH:HS10579-MONOMER
COXPRESdb	5138	http://coxpresdb.jp/data/gene/5138.shtml
CleanEx	HS_PDE2A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_PDE2A
DIP	DIP-40269N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-40269N
DOI	10.1002/pmic.200900783	http://dx.doi.org/10.1002/pmic.200900783
DOI	10.1016/S0378-1119(97)00046-2	http://dx.doi.org/10.1016/S0378-1119(97)00046-2
DOI	10.1021/bi047313h	http://dx.doi.org/10.1021/bi047313h
DOI	10.1021/ja404449g	http://dx.doi.org/10.1021/ja404449g
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0907635106	http://dx.doi.org/10.1073/pnas.0907635106
DOI	10.1074/jbc.M109.017194	http://dx.doi.org/10.1074/jbc.M109.017194
DOI	10.1074/jbc.M111.266379	http://dx.doi.org/10.1074/jbc.M111.266379
DOI	10.1074/mcp.M800588-MCP200	http://dx.doi.org/10.1074/mcp.M800588-MCP200
DrugBank	DB00201	http://www.drugbank.ca/drugs/DB00201
DrugBank	DB08811	http://www.drugbank.ca/drugs/DB08811
EC_number	EC:3.1.4.17	http://www.genome.jp/dbget-bin/www_bget?EC:3.1.4.17
EMBL	AK092278	http://www.ebi.ac.uk/ena/data/view/AK092278
EMBL	AK131525	http://www.ebi.ac.uk/ena/data/view/AK131525
EMBL	AK312434	http://www.ebi.ac.uk/ena/data/view/AK312434
EMBL	AP003065	http://www.ebi.ac.uk/ena/data/view/AP003065
EMBL	AP005019	http://www.ebi.ac.uk/ena/data/view/AP005019
EMBL	AY495087	http://www.ebi.ac.uk/ena/data/view/AY495087
EMBL	AY495088	http://www.ebi.ac.uk/ena/data/view/AY495088
EMBL	AY495089	http://www.ebi.ac.uk/ena/data/view/AY495089
EMBL	U67733	http://www.ebi.ac.uk/ena/data/view/U67733
ENZYME	3.1.4.17	http://enzyme.expasy.org/EC/3.1.4.17
Ensembl	ENST00000334456	http://www.ensembl.org/id/ENST00000334456
Ensembl	ENST00000376450	http://www.ensembl.org/id/ENST00000376450
Ensembl	ENST00000444035	http://www.ensembl.org/id/ENST00000444035
Ensembl	ENST00000540345	http://www.ensembl.org/id/ENST00000540345
Ensembl	ENST00000544570	http://www.ensembl.org/id/ENST00000544570
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005759	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005759
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0042734	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042734
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_function	GO:0004112	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004112
GO_function	GO:0004115	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004115
GO_function	GO:0004118	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004118
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0008144	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008144
GO_function	GO:0030552	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030552
GO_function	GO:0030553	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030553
GO_function	GO:0030911	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030911
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_function	GO:0047555	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047555
GO_process	GO:0000122	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000122
GO_process	GO:0006198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006198
GO_process	GO:0006626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006626
GO_process	GO:0008152	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008152
GO_process	GO:0019933	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019933
GO_process	GO:0019934	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019934
GO_process	GO:0030224	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030224
GO_process	GO:0030818	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030818
GO_process	GO:0033159	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033159
GO_process	GO:0035690	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035690
GO_process	GO:0036006	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036006
GO_process	GO:0043116	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043116
GO_process	GO:0043117	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043117
GO_process	GO:0046069	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046069
GO_process	GO:0050729	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050729
GO_process	GO:0061028	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061028
GO_process	GO:0071260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071260
GO_process	GO:0071321	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071321
GO_process	GO:0071560	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071560
GO_process	GO:0097011	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097011
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0003013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003013
GOslim_process	GO:0006605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0034655	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
Gene3D	1.10.1300.10	http://www.cathdb.info/version/latest/superfamily/1.10.1300.10
Gene3D	3.30.450.40	http://www.cathdb.info/version/latest/superfamily/3.30.450.40
GeneCards	PDE2A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=PDE2A
GeneID	5138	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5138
GeneTree	ENSGT00760000119066	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119066
HGNC	HGNC:8777	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:8777
HOGENOM	HOG000007068	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007068&db=HOGENOM6
HOVERGEN	HBG053540	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053540&db=HOVERGEN
HPA	CAB009752	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB009752
HPA	HPA031192	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031192
IntAct	O00408	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O00408*
IntEnz	3.1.4.17	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.4.17
InterPro	IPR002073	http://www.ebi.ac.uk/interpro/entry/IPR002073
InterPro	IPR003018	http://www.ebi.ac.uk/interpro/entry/IPR003018
InterPro	IPR003607	http://www.ebi.ac.uk/interpro/entry/IPR003607
InterPro	IPR023088	http://www.ebi.ac.uk/interpro/entry/IPR023088
InterPro	IPR023174	http://www.ebi.ac.uk/interpro/entry/IPR023174
InterPro	IPR029016	http://www.ebi.ac.uk/interpro/entry/IPR029016
Jabion	5138	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=5138
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:5138	http://www.genome.jp/dbget-bin/www_bget?hsa:5138
KEGG_Orthology	KO:K01120	http://www.genome.jp/dbget-bin/www_bget?KO:K01120
KEGG_Pathway	ko00230	http://www.genome.jp/kegg-bin/show_pathway?ko00230
KEGG_Pathway	ko05032	http://www.genome.jp/kegg-bin/show_pathway?ko05032
KEGG_Reaction	rn:R00191	http://www.genome.jp/dbget-bin/www_bget?rn:R00191
KEGG_Reaction	rn:R01234	http://www.genome.jp/dbget-bin/www_bget?rn:R01234
MIM	602658	http://www.ncbi.nlm.nih.gov/omim/602658
OMA	NEEWSLQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NEEWSLQ
OrthoDB	EOG091G0L2F	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0L2F
PDB	1Z1L	http://www.ebi.ac.uk/pdbe-srv/view/entry/1Z1L
PDB	3IBJ	http://www.ebi.ac.uk/pdbe-srv/view/entry/3IBJ
PDB	3ITM	http://www.ebi.ac.uk/pdbe-srv/view/entry/3ITM
PDB	3ITU	http://www.ebi.ac.uk/pdbe-srv/view/entry/3ITU
PDB	4C1I	http://www.ebi.ac.uk/pdbe-srv/view/entry/4C1I
PDB	4D08	http://www.ebi.ac.uk/pdbe-srv/view/entry/4D08
PDB	4D09	http://www.ebi.ac.uk/pdbe-srv/view/entry/4D09
PDB	4HTX	http://www.ebi.ac.uk/pdbe-srv/view/entry/4HTX
PDB	4HTZ	http://www.ebi.ac.uk/pdbe-srv/view/entry/4HTZ
PDB	4JIB	http://www.ebi.ac.uk/pdbe-srv/view/entry/4JIB
PDBsum	1Z1L	http://www.ebi.ac.uk/pdbsum/1Z1L
PDBsum	3IBJ	http://www.ebi.ac.uk/pdbsum/3IBJ
PDBsum	3ITM	http://www.ebi.ac.uk/pdbsum/3ITM
PDBsum	3ITU	http://www.ebi.ac.uk/pdbsum/3ITU
PDBsum	4C1I	http://www.ebi.ac.uk/pdbsum/4C1I
PDBsum	4D08	http://www.ebi.ac.uk/pdbsum/4D08
PDBsum	4D09	http://www.ebi.ac.uk/pdbsum/4D09
PDBsum	4HTX	http://www.ebi.ac.uk/pdbsum/4HTX
PDBsum	4HTZ	http://www.ebi.ac.uk/pdbsum/4HTZ
PDBsum	4JIB	http://www.ebi.ac.uk/pdbsum/4JIB
PRINTS	PR00387	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00387
PROSITE	PS00126	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00126
PSORT	swissprot:PDE2A_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:PDE2A_HUMAN
PSORT-B	swissprot:PDE2A_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:PDE2A_HUMAN
PSORT2	swissprot:PDE2A_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:PDE2A_HUMAN
Pfam	PF00233	http://pfam.xfam.org/family/PF00233
Pfam	PF01590	http://pfam.xfam.org/family/PF01590
Pfam	PF13185	http://pfam.xfam.org/family/PF13185
PharmGKB	PA33125	http://www.pharmgkb.org/do/serve?objId=PA33125&objCls=Gene
Phobius	swissprot:PDE2A_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:PDE2A_HUMAN
PhylomeDB	O00408	http://phylomedb.org/?seqid=O00408
ProteinModelPortal	O00408	http://www.proteinmodelportal.org/query/uniprot/O00408
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15938621	http://www.ncbi.nlm.nih.gov/pubmed/15938621
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	19369195	http://www.ncbi.nlm.nih.gov/pubmed/19369195
PubMed	19632989	http://www.ncbi.nlm.nih.gov/pubmed/19632989
PubMed	19828435	http://www.ncbi.nlm.nih.gov/pubmed/19828435
PubMed	20213681	http://www.ncbi.nlm.nih.gov/pubmed/20213681
PubMed	21724846	http://www.ncbi.nlm.nih.gov/pubmed/21724846
PubMed	23899287	http://www.ncbi.nlm.nih.gov/pubmed/23899287
PubMed	9210593	http://www.ncbi.nlm.nih.gov/pubmed/9210593
Reactome	R-HSA-418457	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418457
Reactome	R-HSA-418555	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418555
RefSeq	NP_001137311	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001137311
RefSeq	NP_001139681	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001139681
RefSeq	NP_001230713	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001230713
RefSeq	NP_002590	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002590
SMART	SM00065	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00065
SMART	SM00471	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00471
SMR	O00408	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O00408
STRING	9606.ENSP00000334910	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000334910&targetmode=cogs
SUPFAM	SSF55781	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55781
UCSC	uc001osn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001osn&org=rat
UniGene	Hs.503163	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.503163
UniProtKB	PDE2A_HUMAN	http://www.uniprot.org/uniprot/PDE2A_HUMAN
UniProtKB-AC	O00408	http://www.uniprot.org/uniprot/O00408
charge	swissprot:PDE2A_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:PDE2A_HUMAN
eggNOG	ENOG410XRI7	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRI7
eggNOG	KOG3689	http://eggnogapi.embl.de/nog_data/html/tree/KOG3689
epestfind	swissprot:PDE2A_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:PDE2A_HUMAN
garnier	swissprot:PDE2A_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:PDE2A_HUMAN
helixturnhelix	swissprot:PDE2A_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:PDE2A_HUMAN
hmoment	swissprot:PDE2A_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:PDE2A_HUMAN
iep	swissprot:PDE2A_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:PDE2A_HUMAN
inforesidue	swissprot:PDE2A_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:PDE2A_HUMAN
neXtProt	NX_O00408	http://www.nextprot.org/db/entry/NX_O00408
octanol	swissprot:PDE2A_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:PDE2A_HUMAN
pepcoil	swissprot:PDE2A_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:PDE2A_HUMAN
pepdigest	swissprot:PDE2A_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:PDE2A_HUMAN
pepinfo	swissprot:PDE2A_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:PDE2A_HUMAN
pepnet	swissprot:PDE2A_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:PDE2A_HUMAN
pepstats	swissprot:PDE2A_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:PDE2A_HUMAN
pepwheel	swissprot:PDE2A_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:PDE2A_HUMAN
pepwindow	swissprot:PDE2A_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:PDE2A_HUMAN
sigcleave	swissprot:PDE2A_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:PDE2A_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ZFY16_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7Z3T8-1; Sequence=Displayed; Name=2; IsoId=Q7Z3T8-3; Sequence=VSP_011019, VSP_011020; Note=No experimental confirmation available.; 
# AltName	ZFY16_HUMAN	Endofin
# AltName	ZFY16_HUMAN	Endosome-associated FYVE domain protein
# BioGrid	115111	8
# CCDS	CCDS4050	-. [Q7Z3T8-1]
# ChiTaRS	ZFYVE16	human
# DOMAIN	ZFY16_HUMAN	The FYVE-type zinc finger is necessary and sufficient for its localization into early endosomes and mediates the association with PI3P. {ECO 0000269|PubMed 11546807}. 
# Ensembl	ENST00000338008	ENSP00000337159; ENSG00000039319. [Q7Z3T8-1]
# Ensembl	ENST00000505560	ENSP00000426848; ENSG00000039319. [Q7Z3T8-1]
# Ensembl	ENST00000510158	ENSP00000423663; ENSG00000039319. [Q7Z3T8-1]
# ExpressionAtlas	Q7Z3T8	baseline and differential
# FUNCTION	ZFY16_HUMAN	May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. {ECO 0000269|PubMed 11546807, ECO 0000269|PubMed 14613930}. 
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0005769	early endosome; IDA:UniProtKB.
# GO_component	GO:0031901	early endosome membrane; TAS:Reactome.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_function	GO:0005545	1-phosphatidylinositol binding; IDA:UniProtKB.
# GO_function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding; IDA:UniProtKB.
# GO_function	GO:0008565	protein transporter activity; IMP:UniProtKB.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0006622	protein targeting to lysosome; IMP:UniProtKB.
# GO_process	GO:0007165	signal transduction; NAS:UniProtKB.
# GO_process	GO:0016050	vesicle organization; NAS:UniProtKB.
# GO_process	GO:0016197	endosomal transport; IMP:UniProtKB.
# GO_process	GO:0030100	regulation of endocytosis; TAS:UniProtKB.
# GO_process	GO:0030509	BMP signaling pathway; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0008289	lipid binding
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006605	protein targeting
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007034	vacuolar transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# Gene3D	3.30.40.10	-; 1.
# Genevisible	Q7Z3T8	HS
# HGNC	HGNC:20756	ZFYVE16
# INTERACTION	ZFY16_HUMAN	O60784 TOM1; NbExp=5; IntAct=EBI-298055, EBI-74634; 
# IntAct	Q7Z3T8	7
# InterPro	IPR000306	Znf_FYVE
# InterPro	IPR011011	Znf_FYVE_PHD
# InterPro	IPR013083	Znf_RING/FYVE/PHD
# InterPro	IPR017165	Znf_FYVE_endofin
# InterPro	IPR017455	Znf_FYVE-rel
# InterPro	IPR022557	DUF3480
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Pathway	ko04144	Endocytosis
# KEGG_Pathway	ko04350	TGF-beta signaling pathway
# MIM	608880	gene
# Organism	ZFY16_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR22835:SF43	PTHR22835:SF43; 4
# PDB	3T7L	X-ray; 1.09 A; A=733-820
# PIRSF	PIRSF037289	SARA/endofin
# PROSITE	PS50178	ZF_FYVE
# Pfam	PF01363	FYVE
# Pfam	PF11979	DUF3480
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-201451	Signaling by BMP
# RecName	ZFY16_HUMAN	Zinc finger FYVE domain-containing protein 16
# RefSeq	NP_001098721	NM_001105251.2
# RefSeq	NP_001271165	NM_001284236.1
# RefSeq	NP_001271166	NM_001284237.1
# RefSeq	NP_055548	NM_014733.4
# RefSeq	XP_005248689	XM_005248632.4. [Q7Z3T8-1]
# RefSeq	XP_011542055	XM_011543753.2. [Q7Z3T8-1]
# RefSeq	XP_016865580	XM_017010091.1. [Q7Z3T8-1]
# RefSeq	XP_016865581	XM_017010092.1. [Q7Z3T8-1]
# SEQUENCE CAUTION	Sequence=BAA20764.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO	0000305};
# SIMILARITY	Contains 1 FYVE-type zinc finger. {ECO:0000255|PROSITE-ProRule	PRU00091}. 
# SMART	SM00064	FYVE
# SUBCELLULAR LOCATION	ZFY16_HUMAN	Cytoplasm {ECO 0000269|PubMed 11546807}. Early endosome membrane {ECO 0000269|PubMed 11546807}; Peripheral membrane protein {ECO 0000269|PubMed 11546807}. Note=Localized to early endosomes. Membrane-associated, probably via its association with phosphatidylinositol 3-phosphate (PI3P). 
# SUBUNIT	Interacts with the C-terminus of TOM1. Does not interact with TOM1L1 or TOM1L2. {ECO:0000269|PubMed	14613930, ECO:0000269|Ref.15}. 
# SUPFAM	SSF57903	SSF57903
# TISSUE SPECIFICITY	Widely expressed. Highly expressed in kidney, placenta and lung. Expressed at intermediate level in heart, brain, skeletal muscle, spleen and liver. Weakly expressed in colon, thymus and peripheral blood lymphocytes. {ECO:0000269|PubMed	11546807}. 
# UCSC	uc003kgq	human. [Q7Z3T8-1]
# eggNOG	ENOG410XSEQ	LUCA
# eggNOG	KOG1841	Eukaryota
BLAST	swissprot:ZFY16_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ZFY16_HUMAN
COXPRESdb	9765	http://coxpresdb.jp/data/gene/9765.shtml
CleanEx	HS_ZFYVE16	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ZFYVE16
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/ac035352d	http://dx.doi.org/10.1021/ac035352d
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1038/nbt1046	http://dx.doi.org/10.1038/nbt1046
DOI	10.1038/nbt1240	http://dx.doi.org/10.1038/nbt1240
DOI	10.1056/NEJMoa1206524	http://dx.doi.org/10.1056/NEJMoa1206524
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/jbc.M105917200	http://dx.doi.org/10.1074/jbc.M105917200
DOI	10.1074/jbc.M311228200	http://dx.doi.org/10.1074/jbc.M311228200
DOI	10.1093/dnares/4.2.141	http://dx.doi.org/10.1093/dnares/4.2.141
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AB002303	http://www.ebi.ac.uk/ena/data/view/AB002303
EMBL	AC008771	http://www.ebi.ac.uk/ena/data/view/AC008771
EMBL	AF434817	http://www.ebi.ac.uk/ena/data/view/AF434817
EMBL	AL833087	http://www.ebi.ac.uk/ena/data/view/AL833087
EMBL	BC030808	http://www.ebi.ac.uk/ena/data/view/BC030808
EMBL	BX537424	http://www.ebi.ac.uk/ena/data/view/BX537424
EMBL	CR933621	http://www.ebi.ac.uk/ena/data/view/CR933621
Ensembl	ENST00000338008	http://www.ensembl.org/id/ENST00000338008
Ensembl	ENST00000505560	http://www.ensembl.org/id/ENST00000505560
Ensembl	ENST00000510158	http://www.ensembl.org/id/ENST00000510158
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005769	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005769
GO_component	GO:0031901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031901
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0005545	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005545
GO_function	GO:0005547	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005547
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006622
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0016050	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016050
GO_process	GO:0016197	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016197
GO_process	GO:0030100	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030100
GO_process	GO:0030509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030509
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007034	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007034
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	3.30.40.10	http://www.cathdb.info/version/latest/superfamily/3.30.40.10
GeneCards	ZFYVE16	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ZFYVE16
GeneID	9765	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9765
GeneTree	ENSGT00840000129741	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00840000129741
HGNC	HGNC:20756	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20756
HOVERGEN	HBG098617	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG098617&db=HOVERGEN
HPA	HPA035935	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035935
HPA	HPA035936	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035936
InParanoid	Q7Z3T8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q7Z3T8
IntAct	Q7Z3T8	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q7Z3T8*
InterPro	IPR000306	http://www.ebi.ac.uk/interpro/entry/IPR000306
InterPro	IPR011011	http://www.ebi.ac.uk/interpro/entry/IPR011011
InterPro	IPR013083	http://www.ebi.ac.uk/interpro/entry/IPR013083
InterPro	IPR017165	http://www.ebi.ac.uk/interpro/entry/IPR017165
InterPro	IPR017455	http://www.ebi.ac.uk/interpro/entry/IPR017455
InterPro	IPR022557	http://www.ebi.ac.uk/interpro/entry/IPR022557
Jabion	9765	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9765
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Gene	hsa:9765	http://www.genome.jp/dbget-bin/www_bget?hsa:9765
KEGG_Orthology	KO:K04679	http://www.genome.jp/dbget-bin/www_bget?KO:K04679
KEGG_Pathway	ko04144	http://www.genome.jp/kegg-bin/show_pathway?ko04144
KEGG_Pathway	ko04350	http://www.genome.jp/kegg-bin/show_pathway?ko04350
MIM	608880	http://www.ncbi.nlm.nih.gov/omim/608880
MINT	MINT-1196290	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1196290
OMA	FEQNPDE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FEQNPDE
OrthoDB	EOG091G0VJ6	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0VJ6
PANTHER	PTHR22835:SF43	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22835:SF43
PDB	3T7L	http://www.ebi.ac.uk/pdbe-srv/view/entry/3T7L
PDBsum	3T7L	http://www.ebi.ac.uk/pdbsum/3T7L
PROSITE	PS50178	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50178
PSORT	swissprot:ZFY16_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ZFY16_HUMAN
PSORT-B	swissprot:ZFY16_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ZFY16_HUMAN
PSORT2	swissprot:ZFY16_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ZFY16_HUMAN
Pfam	PF01363	http://pfam.xfam.org/family/PF01363
Pfam	PF11979	http://pfam.xfam.org/family/PF11979
PharmGKB	PA134873366	http://www.pharmgkb.org/do/serve?objId=PA134873366&objCls=Gene
Phobius	swissprot:ZFY16_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ZFY16_HUMAN
PhylomeDB	Q7Z3T8	http://phylomedb.org/?seqid=Q7Z3T8
ProteinModelPortal	Q7Z3T8	http://www.proteinmodelportal.org/query/uniprot/Q7Z3T8
PubMed	11546807	http://www.ncbi.nlm.nih.gov/pubmed/11546807
PubMed	14613930	http://www.ncbi.nlm.nih.gov/pubmed/14613930
PubMed	15144186	http://www.ncbi.nlm.nih.gov/pubmed/15144186
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15592455	http://www.ncbi.nlm.nih.gov/pubmed/15592455
PubMed	16964243	http://www.ncbi.nlm.nih.gov/pubmed/16964243
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23033978	http://www.ncbi.nlm.nih.gov/pubmed/23033978
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	9205841	http://www.ncbi.nlm.nih.gov/pubmed/9205841
Reactome	R-HSA-201451	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-201451
RefSeq	NP_001098721	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001098721
RefSeq	NP_001271165	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001271165
RefSeq	NP_001271166	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001271166
RefSeq	NP_055548	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055548
RefSeq	XP_005248689	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005248689
RefSeq	XP_011542055	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011542055
RefSeq	XP_016865580	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016865580
RefSeq	XP_016865581	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016865581
SMART	SM00064	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00064
SMR	Q7Z3T8	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q7Z3T8
STRING	9606.ENSP00000337159	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000337159&targetmode=cogs
SUPFAM	SSF57903	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF57903
UCSC	uc003kgq	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003kgq&org=rat
UniGene	Hs.482660	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.482660
UniGene	Hs.660410	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.660410
UniProtKB	ZFY16_HUMAN	http://www.uniprot.org/uniprot/ZFY16_HUMAN
UniProtKB-AC	Q7Z3T8	http://www.uniprot.org/uniprot/Q7Z3T8
charge	swissprot:ZFY16_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ZFY16_HUMAN
eggNOG	ENOG410XSEQ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSEQ
eggNOG	KOG1841	http://eggnogapi.embl.de/nog_data/html/tree/KOG1841
epestfind	swissprot:ZFY16_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ZFY16_HUMAN
garnier	swissprot:ZFY16_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ZFY16_HUMAN
helixturnhelix	swissprot:ZFY16_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZFY16_HUMAN
hmoment	swissprot:ZFY16_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ZFY16_HUMAN
iep	swissprot:ZFY16_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ZFY16_HUMAN
inforesidue	swissprot:ZFY16_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ZFY16_HUMAN
neXtProt	NX_Q7Z3T8	http://www.nextprot.org/db/entry/NX_Q7Z3T8
octanol	swissprot:ZFY16_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ZFY16_HUMAN
pepcoil	swissprot:ZFY16_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ZFY16_HUMAN
pepdigest	swissprot:ZFY16_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ZFY16_HUMAN
pepinfo	swissprot:ZFY16_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ZFY16_HUMAN
pepnet	swissprot:ZFY16_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ZFY16_HUMAN
pepstats	swissprot:ZFY16_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ZFY16_HUMAN
pepwheel	swissprot:ZFY16_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ZFY16_HUMAN
pepwindow	swissprot:ZFY16_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ZFY16_HUMAN
sigcleave	swissprot:ZFY16_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ZFY16_HUMAN
## Database	ID	URL or Descriptions
# AltName	VIAAT_HUMAN	GABA and glycine transporter
# AltName	VIAAT_HUMAN	Solute carrier family 32 member 1
# AltName	VIAAT_HUMAN	Vesicular GABA transporter
# BioGrid	126644	2
# DrugBank	DB00145	Glycine
# Ensembl	ENST00000217420	ENSP00000217420; ENSG00000101438
# FUNCTION	VIAAT_HUMAN	Involved in the uptake of GABA and glycine into the synaptic vesicles. {ECO 0000250|UniProtKB O35458}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0030425	dendrite; IDA:MGI.
# GO_component	GO:0030672	synaptic vesicle membrane; TAS:Reactome.
# GO_component	GO:0043005	neuron projection; IDA:MGI.
# GO_component	GO:0044292	dendrite terminus; IEA:Ensembl.
# GO_component	GO:0044306	neuron projection terminus; IDA:MGI.
# GO_component	GO:0044316	cone cell pedicle; IEA:Ensembl.
# GO_component	GO:0048786	presynaptic active zone; IEA:Ensembl.
# GO_component	GO:0051286	cell tip; IEA:Ensembl.
# GO_component	GO:0060077	inhibitory synapse; IEA:Ensembl.
# GO_component	GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane; TAS:Reactome.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015187	glycine transmembrane transporter activity; IEA:Ensembl.
# GO_function	VIAAT_HUMAN	GO 0005276 vesicular hydrogen amino acid antiporter activity; TAS Reactome.
# GO_function	VIAAT_HUMAN	GO 0015495 gamma-aminobutyric acid proton symporter activity; IEA Ensembl.
# GO_process	GO:0003333	amino acid transmembrane transport; IBA:GO_Central.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0007269	neurotransmitter secretion; TAS:Reactome.
# GO_process	GO:0007568	aging; IEA:Ensembl.
# GO_process	GO:0021766	hippocampus development; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007568	aging
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9H598	HS
# HGNC	HGNC:11018	SLC32A1
# InterPro	IPR013057	AA_transpt_TM
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04727	GABAergic synapse
# KEGG_Pathway	ko05032	Morphine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# MIM	616440	gene
# Organism	VIAAT_HUMAN	Homo sapiens (Human)
# Pfam	PF01490	Aa_trans
# Proteomes	UP000005640	Chromosome 20
# Reactome	R-HSA-425393	Transport of inorganic cations/anions and amino acids/oligopeptides
# Reactome	R-HSA-888590	GABA synthesis, release, reuptake and degradation
# RecName	VIAAT_HUMAN	Vesicular inhibitory amino acid transporter
# RefSeq	NP_542119	NM_080552.2
# SEQUENCE CAUTION	Sequence=AAH36458.2; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the amino acid/polyamine transporter 2 family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	VIAAT_HUMAN	Cytoplasmic vesicle membrane {ECO 0000250|UniProtKB O35458}; Multi-pass membrane protein {ECO 0000255}. 
# TCDB	2.A.18.5	the amino acid/auxin permease (aaap) family
# TISSUE SPECIFICITY	Retina. Expressed throughout the horizontal cells or more specifically at the terminals. {ECO:0000269|PubMed	12115694}. 
# UCSC	uc002xjc	human
# eggNOG	COG0814	LUCA
# eggNOG	KOG4303	Eukaryota
BLAST	swissprot:VIAAT_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VIAAT_HUMAN
BioCyc	ZFISH:MONOMER66-34359	http://biocyc.org/getid?id=ZFISH:MONOMER66-34359
COXPRESdb	140679	http://coxpresdb.jp/data/gene/140679.shtml
CleanEx	HS_SLC32A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC32A1
DOI	10.1002/cne.10272	http://dx.doi.org/10.1002/cne.10272
DOI	10.1038/414865a	http://dx.doi.org/10.1038/414865a
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.2337/diabetes.51.6.1763	http://dx.doi.org/10.2337/diabetes.51.6.1763
DrugBank	DB00145	http://www.drugbank.ca/drugs/DB00145
EMBL	AK055051	http://www.ebi.ac.uk/ena/data/view/AK055051
EMBL	AL133519	http://www.ebi.ac.uk/ena/data/view/AL133519
EMBL	AY044836	http://www.ebi.ac.uk/ena/data/view/AY044836
EMBL	BC036458	http://www.ebi.ac.uk/ena/data/view/BC036458
EMBL	BC053582	http://www.ebi.ac.uk/ena/data/view/BC053582
Ensembl	ENST00000217420	http://www.ensembl.org/id/ENST00000217420
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0030672	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030672
GO_component	GO:0043005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043005
GO_component	GO:0044292	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044292
GO_component	GO:0044306	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044306
GO_component	GO:0044316	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044316
GO_component	GO:0048786	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048786
GO_component	GO:0051286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051286
GO_component	GO:0060077	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060077
GO_component	GO:0061202	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061202
GO_function	GO:0005276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005276
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_function	GO:0015187	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015187
GO_function	GO:0015495	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015495
GO_process	GO:0003333	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003333
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0007269	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007269
GO_process	GO:0007568	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007568
GO_process	GO:0021766	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021766
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007568	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007568
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC32A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC32A1
GeneID	140679	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=140679
GeneTree	ENSGT00490000043380	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00490000043380
HGNC	HGNC:11018	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11018
HOGENOM	HOG000220837	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220837&db=HOGENOM6
HOVERGEN	HBG061364	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG061364&db=HOVERGEN
HPA	CAB037156	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB037156
HPA	HPA058859	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA058859
HPA	HPA059985	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA059985
InParanoid	Q9H598	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9H598
IntAct	Q9H598	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9H598*
InterPro	IPR013057	http://www.ebi.ac.uk/interpro/entry/IPR013057
Jabion	140679	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=140679
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:140679	http://www.genome.jp/dbget-bin/www_bget?hsa:140679
KEGG_Orthology	KO:K15015	http://www.genome.jp/dbget-bin/www_bget?KO:K15015
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
KEGG_Pathway	ko05032	http://www.genome.jp/kegg-bin/show_pathway?ko05032
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
MIM	616440	http://www.ncbi.nlm.nih.gov/omim/616440
OMA	ANACCSP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ANACCSP
OrthoDB	EOG091G05MY	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05MY
PSORT	swissprot:VIAAT_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VIAAT_HUMAN
PSORT-B	swissprot:VIAAT_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VIAAT_HUMAN
PSORT2	swissprot:VIAAT_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VIAAT_HUMAN
Pfam	PF01490	http://pfam.xfam.org/family/PF01490
PharmGKB	PA401	http://www.pharmgkb.org/do/serve?objId=PA401&objCls=Gene
Phobius	swissprot:VIAAT_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VIAAT_HUMAN
PhylomeDB	Q9H598	http://phylomedb.org/?seqid=Q9H598
ProteinModelPortal	Q9H598	http://www.proteinmodelportal.org/query/uniprot/Q9H598
PubMed	11780052	http://www.ncbi.nlm.nih.gov/pubmed/11780052
PubMed	12031963	http://www.ncbi.nlm.nih.gov/pubmed/12031963
PubMed	12115694	http://www.ncbi.nlm.nih.gov/pubmed/12115694
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-425393	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425393
Reactome	R-HSA-888590	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-888590
RefSeq	NP_542119	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_542119
STRING	9606.ENSP00000217420	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000217420&targetmode=cogs
TCDB	2.A.18.5	http://www.tcdb.org/search/result.php?tc=2.A.18.5
UCSC	uc002xjc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002xjc&org=rat
UniGene	Hs.179080	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.179080
UniProtKB	VIAAT_HUMAN	http://www.uniprot.org/uniprot/VIAAT_HUMAN
UniProtKB-AC	Q9H598	http://www.uniprot.org/uniprot/Q9H598
charge	swissprot:VIAAT_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VIAAT_HUMAN
eggNOG	COG0814	http://eggnogapi.embl.de/nog_data/html/tree/COG0814
eggNOG	KOG4303	http://eggnogapi.embl.de/nog_data/html/tree/KOG4303
epestfind	swissprot:VIAAT_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VIAAT_HUMAN
garnier	swissprot:VIAAT_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VIAAT_HUMAN
helixturnhelix	swissprot:VIAAT_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VIAAT_HUMAN
hmoment	swissprot:VIAAT_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VIAAT_HUMAN
iep	swissprot:VIAAT_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VIAAT_HUMAN
inforesidue	swissprot:VIAAT_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VIAAT_HUMAN
neXtProt	NX_Q9H598	http://www.nextprot.org/db/entry/NX_Q9H598
octanol	swissprot:VIAAT_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VIAAT_HUMAN
pepcoil	swissprot:VIAAT_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VIAAT_HUMAN
pepdigest	swissprot:VIAAT_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VIAAT_HUMAN
pepinfo	swissprot:VIAAT_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VIAAT_HUMAN
pepnet	swissprot:VIAAT_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VIAAT_HUMAN
pepstats	swissprot:VIAAT_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VIAAT_HUMAN
pepwheel	swissprot:VIAAT_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VIAAT_HUMAN
pepwindow	swissprot:VIAAT_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VIAAT_HUMAN
sigcleave	swissprot:VIAAT_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VIAAT_HUMAN
## Database	ID	URL or Descriptions
# AltName	NNTM_HUMAN	Nicotinamide nucleotide transhydrogenase
# AltName	NNTM_HUMAN	Pyridine nucleotide transhydrogenase
# BRENDA	1.6.1	2681
# BioGrid	117076	53
# CATALYTIC ACTIVITY	NNTM_HUMAN	NADPH + NAD(+) = NADP(+) + NADH. 
# ChiTaRS	NNT	human
# DISEASE	NNTM_HUMAN	Glucocorticoid deficiency 4 (GCCD4) [MIM 614736]  A rare, potentially lethal, autosomal recessive disorder characterized by resistance to ACTH action on the adrenal cortex, adrenal insufficiency and an inability of the adrenal cortex to produce cortisol. It usually presents in the neonatal period or in early childhood with episodes of hypoglycemia and other symptoms related to cortisol deficiency, including failure to thrive, recurrent illnesses or infections, convulsions, and shock. In a small number of patients hypoglycemia can be sufficiently severe and persistent that it leads to serious long-term neurological damage or death. The diagnosis is readily confirmed with a low plasma cortisol measurement in the presence of an elevated ACTH level, and normal aldosterone and plasma renin measurements. {ECO 0000269|PubMed 22634753}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000264663	ENSP00000264663; ENSG00000112992
# Ensembl	ENST00000344920	ENSP00000343873; ENSG00000112992
# ExpressionAtlas	Q13423	baseline and differential
# FUNCTION	NNTM_HUMAN	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland. {ECO 0000269|PubMed 22634753}. 
# GO_component	GO:0005739	mitochondrion; IDA:LIFEdb.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:UniProtKB.
# GO_component	GO:0005746	mitochondrial respiratory chain; TAS:UniProtKB.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0003957	NAD(P)+ transhydrogenase (B-specific) activity; TAS:UniProtKB.
# GO_function	GO:0008746	NAD(P)+ transhydrogenase activity; EXP:Reactome.
# GO_function	GO:0008750	NAD(P)+ transhydrogenase (AB-specific) activity; IBA:GO_Central.
# GO_function	GO:0050661	NADP binding; IDA:UniProtKB.
# GO_function	GO:0051287	NAD binding; TAS:UniProtKB.
# GO_process	GO:0006099	tricarboxylic acid cycle; TAS:UniProtKB.
# GO_process	GO:0006740	NADPH regeneration; IBA:GO_Central.
# GO_process	GO:0015992	proton transport; TAS:UniProtKB.
# GO_process	GO:0045454	cell redox homeostasis; IEA:InterPro.
# GO_process	GO:0055114	oxidation-reduction process; TAS:UniProtKB.
# GO_process	GO:0072593	reactive oxygen species metabolic process; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0051186	cofactor metabolic process
# Gene3D	3.40.50.1220	-; 1.
# Gene3D	3.40.50.720	-; 1.
# Genevisible	Q13423	HS
# HGNC	HGNC:7863	NNT
# IntAct	Q13423	19
# InterPro	IPR007698	AlaDH/PNT_NAD(H)-bd
# InterPro	IPR007886	AlaDH/PNT_N
# InterPro	IPR008142	AlaDH/PNT_CS1
# InterPro	IPR008143	Ala_DH/PNT_CS2
# InterPro	IPR012136	NADH_DH_b
# InterPro	IPR016040	NAD(P)-bd_dom
# InterPro	IPR024605	NADP_transhyd_a_C
# InterPro	IPR026255	NADP_transhyd_a
# InterPro	IPR029035	DHS-like_NAD/FAD-binding_dom
# InterPro	IPR030168	NADP_transhyd_mt
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00760	Nicotinate and nicotinamide metabolism
# MIM	607878	gene
# MIM	614736	phenotype
# Organism	NNTM_HUMAN	Homo sapiens (Human)
# Orphanet	361	Familial glucocorticoid deficiency
# PANTHER	PTHR10160:SF22	PTHR10160:SF22
# PDB	1DJL	X-ray; 2.00 A; A/B=880-1086
# PDB	1PT9	X-ray; 2.42 A; A/B=880-1086
# PDB	1U31	X-ray; 2.20 A; A/B=880-1086
# PIR	G02257	G02257
# PROSITE	PS00836	ALADH_PNT_1
# PROSITE	PS00837	ALADH_PNT_2
# Pfam	PF01262	AlaDh_PNT_C
# Pfam	PF02233	PNTB
# Pfam	PF05222	AlaDh_PNT_N
# Pfam	PF12769	PNTB_4TM
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-71403	Citric acid cycle (TCA cycle)
# RecName	NNTM_HUMAN	NAD(P) transhydrogenase, mitochondrial
# RefSeq	NP_036475	NM_012343.3
# RefSeq	NP_892022	NM_182977.2
# RefSeq	XP_005248331	XM_005248274.4
# RefSeq	XP_011512303	XM_011514001.2
# RefSeq	XP_016864782	XM_017009293.1
# SIMILARITY	In the C-terminal section; belongs to the PNT beta subunit family. {ECO	0000305}.
# SIMILARITY	In the N-terminal section; belongs to the AlaDH/PNT family. {ECO	0000305}. 
# SMART	SM01002	AlaDh_PNT_C
# SMART	SM01003	AlaDh_PNT_N
# SUBCELLULAR LOCATION	NNTM_HUMAN	Mitochondrion inner membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}; Matrix side {ECO 0000305}. 
# SUBUNIT	Homodimer. {ECO	0000250}. 
# SUPFAM	SSF51735	SSF51735
# SUPFAM	SSF52467	SSF52467
# TIGRFAMs	TIGR00561	pntA
# TISSUE SPECIFICITY	Widely expressed with expression most readily detectable in adrenal, heart, kidney, thyroid and adipose tissues. {ECO:0000269|PubMed	22634753}. 
# UCSC	uc003joe	human
# eggNOG	COG1282	LUCA
# eggNOG	COG3288	LUCA
# eggNOG	ENOG410IEMU	Eukaryota
BLAST	swissprot:NNTM_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NNTM_HUMAN
BioCyc	MetaCyc:HS03639-MONOMER	http://biocyc.org/getid?id=MetaCyc:HS03639-MONOMER
BioCyc	ZFISH:HS03639-MONOMER	http://biocyc.org/getid?id=ZFISH:HS03639-MONOMER
COXPRESdb	23530	http://coxpresdb.jp/data/gene/23530.shtml
CleanEx	HS_NNT	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_NNT
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/0005-2728(95)00159-X	http://dx.doi.org/10.1016/0005-2728(95)00159-X
DOI	10.1016/S0969-2126(00)00075-7	http://dx.doi.org/10.1016/S0969-2126(00)00075-7
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/ng.2299	http://dx.doi.org/10.1038/ng.2299
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EC_number	EC:1.6.1.2	http://www.genome.jp/dbget-bin/www_bget?EC:1.6.1.2
EMBL	AL831822	http://www.ebi.ac.uk/ena/data/view/AL831822
EMBL	BC110543	http://www.ebi.ac.uk/ena/data/view/BC110543
EMBL	U40490	http://www.ebi.ac.uk/ena/data/view/U40490
EMBL	Z50101	http://www.ebi.ac.uk/ena/data/view/Z50101
ENZYME	1.6.1.2	http://enzyme.expasy.org/EC/1.6.1.2
Ensembl	ENST00000264663	http://www.ensembl.org/id/ENST00000264663
Ensembl	ENST00000344920	http://www.ensembl.org/id/ENST00000344920
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005746	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005746
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0003957	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003957
GO_function	GO:0008746	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008746
GO_function	GO:0008750	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008750
GO_function	GO:0050661	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050661
GO_function	GO:0051287	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287
GO_process	GO:0006099	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006099
GO_process	GO:0006740	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006740
GO_process	GO:0015992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992
GO_process	GO:0045454	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045454
GO_process	GO:0055114	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114
GO_process	GO:0072593	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072593
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0051186	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186
Gene3D	3.40.50.1220	http://www.cathdb.info/version/latest/superfamily/3.40.50.1220
Gene3D	3.40.50.720	http://www.cathdb.info/version/latest/superfamily/3.40.50.720
GeneCards	NNT	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=NNT
GeneID	23530	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23530
GeneTree	ENSGT00390000004624	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000004624
H-InvDB	HIX0032203	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0032203
HGNC	HGNC:7863	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:7863
HOGENOM	HOG000160623	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000160623&db=HOGENOM6
HOVERGEN	HBG006511	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006511&db=HOVERGEN
HPA	CAB004975	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB004975
HPA	HPA004829	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA004829
InParanoid	Q13423	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q13423
IntAct	Q13423	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q13423*
IntEnz	1.6.1.2	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.6.1.2
InterPro	IPR007698	http://www.ebi.ac.uk/interpro/entry/IPR007698
InterPro	IPR007886	http://www.ebi.ac.uk/interpro/entry/IPR007886
InterPro	IPR008142	http://www.ebi.ac.uk/interpro/entry/IPR008142
InterPro	IPR008143	http://www.ebi.ac.uk/interpro/entry/IPR008143
InterPro	IPR012136	http://www.ebi.ac.uk/interpro/entry/IPR012136
InterPro	IPR016040	http://www.ebi.ac.uk/interpro/entry/IPR016040
InterPro	IPR024605	http://www.ebi.ac.uk/interpro/entry/IPR024605
InterPro	IPR026255	http://www.ebi.ac.uk/interpro/entry/IPR026255
InterPro	IPR029035	http://www.ebi.ac.uk/interpro/entry/IPR029035
InterPro	IPR030168	http://www.ebi.ac.uk/interpro/entry/IPR030168
Jabion	23530	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=23530
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:23530	http://www.genome.jp/dbget-bin/www_bget?hsa:23530
KEGG_Orthology	KO:K00323	http://www.genome.jp/dbget-bin/www_bget?KO:K00323
KEGG_Pathway	ko00760	http://www.genome.jp/kegg-bin/show_pathway?ko00760
KEGG_Reaction	rn:R00112	http://www.genome.jp/dbget-bin/www_bget?rn:R00112
MIM	607878	http://www.ncbi.nlm.nih.gov/omim/607878
MIM	614736	http://www.ncbi.nlm.nih.gov/omim/614736
MINT	MINT-3027647	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3027647
OMA	KPGIPYK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KPGIPYK
Orphanet	361	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=361
OrthoDB	EOG091G01NO	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01NO
PANTHER	PTHR10160:SF22	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10160:SF22
PDB	1DJL	http://www.ebi.ac.uk/pdbe-srv/view/entry/1DJL
PDB	1PT9	http://www.ebi.ac.uk/pdbe-srv/view/entry/1PT9
PDB	1U31	http://www.ebi.ac.uk/pdbe-srv/view/entry/1U31
PDBsum	1DJL	http://www.ebi.ac.uk/pdbsum/1DJL
PDBsum	1PT9	http://www.ebi.ac.uk/pdbsum/1PT9
PDBsum	1U31	http://www.ebi.ac.uk/pdbsum/1U31
PROSITE	PS00836	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00836
PROSITE	PS00837	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00837
PSORT	swissprot:NNTM_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NNTM_HUMAN
PSORT-B	swissprot:NNTM_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NNTM_HUMAN
PSORT2	swissprot:NNTM_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NNTM_HUMAN
Pfam	PF01262	http://pfam.xfam.org/family/PF01262
Pfam	PF02233	http://pfam.xfam.org/family/PF02233
Pfam	PF05222	http://pfam.xfam.org/family/PF05222
Pfam	PF12769	http://pfam.xfam.org/family/PF12769
PharmGKB	PA31667	http://www.pharmgkb.org/do/serve?objId=PA31667&objCls=Gene
Phobius	swissprot:NNTM_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NNTM_HUMAN
PhylomeDB	Q13423	http://phylomedb.org/?seqid=Q13423
ProteinModelPortal	Q13423	http://www.proteinmodelportal.org/query/uniprot/Q13423
PubMed	10673423	http://www.ncbi.nlm.nih.gov/pubmed/10673423
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22634753	http://www.ncbi.nlm.nih.gov/pubmed/22634753
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	8616157	http://www.ncbi.nlm.nih.gov/pubmed/8616157
PubMed	9524818	http://www.ncbi.nlm.nih.gov/pubmed/9524818
Reactome	R-HSA-71403	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-71403
RefSeq	NP_036475	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_036475
RefSeq	NP_892022	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_892022
RefSeq	XP_005248331	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005248331
RefSeq	XP_011512303	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011512303
RefSeq	XP_016864782	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016864782
SMART	SM01002	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01002
SMART	SM01003	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01003
SMR	Q13423	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q13423
STRING	9606.ENSP00000264663	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000264663&targetmode=cogs
SUPFAM	SSF51735	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735
SUPFAM	SSF52467	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52467
TIGRFAMs	TIGR00561	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00561
UCSC	uc003joe	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003joe&org=rat
UniGene	Hs.482043	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.482043
UniProtKB	NNTM_HUMAN	http://www.uniprot.org/uniprot/NNTM_HUMAN
UniProtKB-AC	Q13423	http://www.uniprot.org/uniprot/Q13423
charge	swissprot:NNTM_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NNTM_HUMAN
eggNOG	COG1282	http://eggnogapi.embl.de/nog_data/html/tree/COG1282
eggNOG	COG3288	http://eggnogapi.embl.de/nog_data/html/tree/COG3288
eggNOG	ENOG410IEMU	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IEMU
epestfind	swissprot:NNTM_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NNTM_HUMAN
garnier	swissprot:NNTM_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NNTM_HUMAN
helixturnhelix	swissprot:NNTM_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NNTM_HUMAN
hmoment	swissprot:NNTM_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NNTM_HUMAN
iep	swissprot:NNTM_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NNTM_HUMAN
inforesidue	swissprot:NNTM_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NNTM_HUMAN
neXtProt	NX_Q13423	http://www.nextprot.org/db/entry/NX_Q13423
octanol	swissprot:NNTM_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NNTM_HUMAN
pepcoil	swissprot:NNTM_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NNTM_HUMAN
pepdigest	swissprot:NNTM_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NNTM_HUMAN
pepinfo	swissprot:NNTM_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NNTM_HUMAN
pepnet	swissprot:NNTM_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NNTM_HUMAN
pepstats	swissprot:NNTM_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NNTM_HUMAN
pepwheel	swissprot:NNTM_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NNTM_HUMAN
pepwindow	swissprot:NNTM_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NNTM_HUMAN
sigcleave	swissprot:NNTM_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NNTM_HUMAN
## Database	ID	URL or Descriptions
# AltName	RAMP3_HUMAN	Calcitonin-receptor-like receptor activity-modifying protein 3
# BioGrid	115559	7
# ChiTaRS	RAMP3	human
# DrugBank	DB01278	Pramlintide
# Ensembl	ENST00000242249	ENSP00000242249; ENSG00000122679
# Ensembl	ENST00000481345	ENSP00000419012; ENSG00000122679
# ExpressionAtlas	O60896	baseline and differential
# FUNCTION	RAMP3_HUMAN	Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. {ECO 0000269|PubMed 23674134, ECO 0000269|PubMed 9620797}. 
# GO_component	GO:0005622	intracellular; IDA:UniProtKB.
# GO_component	GO:0005764	lysosome; TAS:ProtInc.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0009986	cell surface; IDA:UniProtKB.
# GO_component	GO:0043235	receptor complex; IDA:UniProtKB.
# GO_function	GO:0004872	receptor activity; IDA:UniProtKB.
# GO_function	GO:0008565	protein transporter activity; IDA:UniProtKB.
# GO_function	GO:0015026	coreceptor activity; IEA:Ensembl.
# GO_process	GO:0001921	positive regulation of receptor recycling; IDA:UniProtKB.
# GO_process	GO:0006816	calcium ion transport; IDA:UniProtKB.
# GO_process	GO:0006886	intracellular protein transport; IEA:InterPro.
# GO_process	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway; IEA:InterPro.
# GO_process	GO:0015031	protein transport; IDA:UniProtKB.
# GO_process	GO:0031623	receptor internalization; IDA:UniProtKB.
# GO_process	GO:0045892	negative regulation of transcription, DNA-templated; IMP:UniProtKB.
# GO_process	GO:0071392	cellular response to estradiol stimulus; ISS:UniProtKB.
# GO_process	GO:0072659	protein localization to plasma membrane; IDA:UniProtKB.
# GO_process	GO:0086103	G-protein coupled receptor signaling pathway involved in heart process; ISS:UniProtKB.
# GO_process	GO:0090004	positive regulation of establishment of protein localization to plasma membrane; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005622	intracellular
# GOslim_component	GO:0005764	lysosome
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007009	plasma membrane organization
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# Genevisible	O60896	HS
# HGNC	HGNC:9845	RAMP3
# INTERACTION	RAMP3_HUMAN	P26371 KRTAP5-9; NbExp=3; IntAct=EBI-720447, EBI-3958099; Q7Z3S9 NOTCH2NL; NbExp=5; IntAct=EBI-720447, EBI-945833; 
# IntAct	O60896	6
# InterPro	IPR006985	RAMP
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04030	 G protein-coupled receptors
# KEGG_Pathway	ko04270	Vascular smooth muscle contraction
# MIM	605155	gene
# Organism	RAMP3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR14076	PTHR14076
# Pfam	PF04901	RAMP
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-418555	G alpha (s) signalling events
# Reactome	R-HSA-419812	Calcitonin-like ligand receptors
# RecName	RAMP3_HUMAN	Receptor activity-modifying protein 3
# RefSeq	NP_005847	NM_005856.2
# SIMILARITY	Belongs to the RAMP family. {ECO	0000305}.
# SUBCELLULAR LOCATION	RAMP3_HUMAN	Cell membrane {ECO 0000269|PubMed 23674134}; Single-pass type I membrane protein {ECO 0000269|PubMed 23674134}. Membrane {ECO 0000269|PubMed 23674134}; Single-pass type I membrane protein {ECO 0000269|PubMed 23674134}. Note=Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner. 
# SUBUNIT	Heterodimer of CALCRL and RAMP3 (By similarity). Interacts with GPER1. {ECO:0000250, ECO	0000269|PubMed:23674134}. 
# TISSUE SPECIFICITY	Strongly expressed in lung, breast, immune system and fetal tissues. {ECO:0000269|PubMed	9620797}. 
# UCSC	uc003tnb	human
# eggNOG	ENOG410IXGF	Eukaryota
# eggNOG	ENOG4111U8C	LUCA
BLAST	swissprot:RAMP3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:RAMP3_HUMAN
BioCyc	ZFISH:ENSG00000122679-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000122679-MONOMER
COXPRESdb	10268	http://coxpresdb.jp/data/gene/10268.shtml
CleanEx	HS_RAMP3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_RAMP3
DOI	10.1038/30666	http://dx.doi.org/10.1038/30666
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1530/JME-13-0021	http://dx.doi.org/10.1530/JME-13-0021
DrugBank	DB01278	http://www.drugbank.ca/drugs/DB01278
EMBL	AC004844	http://www.ebi.ac.uk/ena/data/view/AC004844
EMBL	AJ001016	http://www.ebi.ac.uk/ena/data/view/AJ001016
EMBL	AY265459	http://www.ebi.ac.uk/ena/data/view/AY265459
EMBL	BC022304	http://www.ebi.ac.uk/ena/data/view/BC022304
EMBL	BC053852	http://www.ebi.ac.uk/ena/data/view/BC053852
Ensembl	ENST00000242249	http://www.ensembl.org/id/ENST00000242249
Ensembl	ENST00000481345	http://www.ensembl.org/id/ENST00000481345
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GO_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0043235	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043235
GO_function	GO:0004872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004872
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0015026	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015026
GO_process	GO:0001921	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001921
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0006886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006886
GO_process	GO:0008277	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008277
GO_process	GO:0015031	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031
GO_process	GO:0031623	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031623
GO_process	GO:0045892	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892
GO_process	GO:0071392	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071392
GO_process	GO:0072659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072659
GO_process	GO:0086103	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086103
GO_process	GO:0090004	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090004
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GOslim_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007009
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GeneCards	RAMP3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=RAMP3
GeneID	10268	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10268
GeneTree	ENSGT00390000016200	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000016200
HGNC	HGNC:9845	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:9845
HOGENOM	HOG000253018	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000253018&db=HOGENOM6
HOVERGEN	HBG061268	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG061268&db=HOVERGEN
InParanoid	O60896	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O60896
IntAct	O60896	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O60896*
InterPro	IPR006985	http://www.ebi.ac.uk/interpro/entry/IPR006985
Jabion	10268	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10268
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04030	http://www.genome.jp/dbget-bin/www_bget?ko04030
KEGG_Gene	hsa:10268	http://www.genome.jp/dbget-bin/www_bget?hsa:10268
KEGG_Orthology	KO:K08449	http://www.genome.jp/dbget-bin/www_bget?KO:K08449
KEGG_Pathway	ko04270	http://www.genome.jp/kegg-bin/show_pathway?ko04270
MIM	605155	http://www.ncbi.nlm.nih.gov/omim/605155
MINT	MINT-1384016	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1384016
PANTHER	PTHR14076	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14076
PSORT	swissprot:RAMP3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:RAMP3_HUMAN
PSORT-B	swissprot:RAMP3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:RAMP3_HUMAN
PSORT2	swissprot:RAMP3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:RAMP3_HUMAN
Pfam	PF04901	http://pfam.xfam.org/family/PF04901
PharmGKB	PA34204	http://www.pharmgkb.org/do/serve?objId=PA34204&objCls=Gene
Phobius	swissprot:RAMP3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:RAMP3_HUMAN
PhylomeDB	O60896	http://phylomedb.org/?seqid=O60896
ProteinModelPortal	O60896	http://www.proteinmodelportal.org/query/uniprot/O60896
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	23674134	http://www.ncbi.nlm.nih.gov/pubmed/23674134
PubMed	9620797	http://www.ncbi.nlm.nih.gov/pubmed/9620797
Reactome	R-HSA-418555	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418555
Reactome	R-HSA-419812	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-419812
RefSeq	NP_005847	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005847
STRING	9606.ENSP00000242249	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000242249&targetmode=cogs
UCSC	uc003tnb	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003tnb&org=rat
UniGene	Hs.25691	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.25691
UniProtKB	RAMP3_HUMAN	http://www.uniprot.org/uniprot/RAMP3_HUMAN
UniProtKB-AC	O60896	http://www.uniprot.org/uniprot/O60896
charge	swissprot:RAMP3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:RAMP3_HUMAN
eggNOG	ENOG410IXGF	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IXGF
eggNOG	ENOG4111U8C	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111U8C
epestfind	swissprot:RAMP3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:RAMP3_HUMAN
garnier	swissprot:RAMP3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:RAMP3_HUMAN
helixturnhelix	swissprot:RAMP3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:RAMP3_HUMAN
hmoment	swissprot:RAMP3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:RAMP3_HUMAN
iep	swissprot:RAMP3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:RAMP3_HUMAN
inforesidue	swissprot:RAMP3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:RAMP3_HUMAN
neXtProt	NX_O60896	http://www.nextprot.org/db/entry/NX_O60896
octanol	swissprot:RAMP3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:RAMP3_HUMAN
pepcoil	swissprot:RAMP3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:RAMP3_HUMAN
pepdigest	swissprot:RAMP3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:RAMP3_HUMAN
pepinfo	swissprot:RAMP3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:RAMP3_HUMAN
pepnet	swissprot:RAMP3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:RAMP3_HUMAN
pepstats	swissprot:RAMP3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:RAMP3_HUMAN
pepwheel	swissprot:RAMP3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:RAMP3_HUMAN
pepwindow	swissprot:RAMP3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:RAMP3_HUMAN
sigcleave	swissprot:RAMP3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:RAMP3_HUMAN
## Database	ID	URL or Descriptions
# AltName	TOM22_HUMAN	1C9-2
# AltName	TOM22_HUMAN	Translocase of outer membrane 22 kDa subunit homolog
# BioGrid	121308	70
# ChiTaRS	TOMM22	human
# DOMAIN	TOM22_HUMAN	Requires the transmembrane domain (TMD), a short segment (the import sequence) in the cytoplasmic domain localizing separately from the TMD and the C-tail signal in the C-terminal domain for efficient targeting and integration into the TOM complex (By similarity). The N-terminal domain (residues 1-62) is important for binding to the unfolded mature imported proteins. Residues (49-71) of the cytoplasmic domain interacts with TOMM20 while the C-terminal segment (residues 63-82) binds presequence of preproteins. {ECO 0000250}. 
# Ensembl	ENST00000216034	ENSP00000216034; ENSG00000100216
# ExpressionAtlas	Q9NS69	baseline and differential
# FUNCTION	TOM22_HUMAN	Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore. {ECO 0000269|PubMed 10982837}. 
# GO_component	GO:0005739	mitochondrion; IDA:HPA.
# GO_component	GO:0005741	mitochondrial outer membrane; TAS:Reactome.
# GO_component	GO:0005742	mitochondrial outer membrane translocase complex; IDA:BHF-UCL.
# GO_component	GO:0005743	mitochondrial inner membrane; IEA:Ensembl.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IDA:BHF-UCL.
# GO_component	GO:0031307	integral component of mitochondrial outer membrane; IBA:GO_Central.
# GO_function	GO:0008320	protein transmembrane transporter activity; ISS:BHF-UCL.
# GO_process	GO:0006626	protein targeting to mitochondrion; TAS:HGNC.
# GO_process	GO:0016236	macroautophagy; TAS:Reactome.
# GO_process	GO:0030150	protein import into mitochondrial matrix; IBA:GO_Central.
# GO_process	GO:0045040	protein import into mitochondrial outer membrane; IDA:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006605	protein targeting
# GOslim_process	GO:0006914	autophagy
# GOslim_process	GO:0007005	mitochondrion organization
# GOslim_process	GO:0055085	transmembrane transport
# GOslim_process	GO:0061024	membrane organization
# Genevisible	Q9NS69	HS
# HGNC	HGNC:18002	TOMM22
# INTERACTION	TOM22_HUMAN	P03419 M (xeno); NbExp=2; IntAct=EBI-1047508, EBI-10042882; Q9P0U1 TOMM7; NbExp=2; IntAct=EBI-1047508, EBI-1180558; 
# IntAct	Q9NS69	14
# InterPro	IPR005683	Tom22
# MIM	607046	gene
# Organism	TOM22_HUMAN	Homo sapiens (Human)
# Pfam	PF04281	Tom22
# Proteomes	UP000005640	Chromosome 22
# Reactome	R-HSA-1268020	Mitochondrial protein import
# Reactome	R-HSA-5205685	Pink/Parkin Mediated Mitophagy
# RecName	TOM22_HUMAN	Mitochondrial import receptor subunit TOM22 homolog
# RefSeq	NP_064628	NM_020243.4
# SIMILARITY	Belongs to the Tom22 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	TOM22_HUMAN	Mitochondrion outer membrane {ECO 0000269|PubMed 10982837}; Single-pass membrane protein {ECO 0000269|PubMed 10982837}. 
# SUBUNIT	TOM22_HUMAN	Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70) (PubMed 18331822). Interacts with TOMM40. Interacts with PPP2R2B (By similarity). {ECO 0000250|UniProtKB Q75Q41, ECO 0000269|PubMed 18331822}. 
# TISSUE SPECIFICITY	TOM22_HUMAN	Ubiquitous. 
# UCSC	uc003awe	human
# eggNOG	ENOG41122K3	LUCA
# eggNOG	KOG4111	Eukaryota
BLAST	swissprot:TOM22_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TOM22_HUMAN
BioCyc	ZFISH:ENSG00000100216-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000100216-MONOMER
COXPRESdb	56993	http://coxpresdb.jp/data/gene/56993.shtml
CleanEx	HS_TOMM22	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TOMM22
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.bbrc.2008.02.150	http://dx.doi.org/10.1016/j.bbrc.2008.02.150
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/jbc.M004794200	http://dx.doi.org/10.1074/jbc.M004794200
DOI	10.1074/mcp.M111.015131	http://dx.doi.org/10.1074/mcp.M111.015131
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1128/MCB.20.19.7205-7213.2000	http://dx.doi.org/10.1128/MCB.20.19.7205-7213.2000
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1186/gb-2004-5-10-r84	http://dx.doi.org/10.1186/gb-2004-5-10-r84
EMBL	AB040119	http://www.ebi.ac.uk/ena/data/view/AB040119
EMBL	AB041906	http://www.ebi.ac.uk/ena/data/view/AB041906
EMBL	AK024731	http://www.ebi.ac.uk/ena/data/view/AK024731
EMBL	BC009363	http://www.ebi.ac.uk/ena/data/view/BC009363
EMBL	CR456475	http://www.ebi.ac.uk/ena/data/view/CR456475
Ensembl	ENST00000216034	http://www.ensembl.org/id/ENST00000216034
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005741	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005741
GO_component	GO:0005742	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005742
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0031307	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031307
GO_function	GO:0008320	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008320
GO_process	GO:0006626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006626
GO_process	GO:0016236	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016236
GO_process	GO:0030150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030150
GO_process	GO:0045040	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045040
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605
GOslim_process	GO:0006914	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006914
GOslim_process	GO:0007005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007005
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
GeneCards	TOMM22	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TOMM22
GeneID	56993	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56993
GeneTree	ENSGT00390000016475	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000016475
HGNC	HGNC:18002	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18002
HOGENOM	HOG000067816	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000067816&db=HOGENOM6
HOVERGEN	HBG061819	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG061819&db=HOVERGEN
HPA	HPA003037	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA003037
InParanoid	Q9NS69	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NS69
IntAct	Q9NS69	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NS69*
InterPro	IPR005683	http://www.ebi.ac.uk/interpro/entry/IPR005683
Jabion	56993	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=56993
KEGG_Gene	hsa:56993	http://www.genome.jp/dbget-bin/www_bget?hsa:56993
MIM	607046	http://www.ncbi.nlm.nih.gov/omim/607046
OMA	FYTFSCN	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FYTFSCN
OrthoDB	EOG091G0XN1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0XN1
PSORT	swissprot:TOM22_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TOM22_HUMAN
PSORT-B	swissprot:TOM22_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TOM22_HUMAN
PSORT2	swissprot:TOM22_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TOM22_HUMAN
Pfam	PF04281	http://pfam.xfam.org/family/PF04281
PharmGKB	PA38275	http://www.pharmgkb.org/do/serve?objId=PA38275&objCls=Gene
Phobius	swissprot:TOM22_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TOM22_HUMAN
PhylomeDB	Q9NS69	http://phylomedb.org/?seqid=Q9NS69
ProteinModelPortal	Q9NS69	http://www.proteinmodelportal.org/query/uniprot/Q9NS69
PubMed	10900208	http://www.ncbi.nlm.nih.gov/pubmed/10900208
PubMed	10982837	http://www.ncbi.nlm.nih.gov/pubmed/10982837
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15461802	http://www.ncbi.nlm.nih.gov/pubmed/15461802
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	18331822	http://www.ncbi.nlm.nih.gov/pubmed/18331822
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	22223895	http://www.ncbi.nlm.nih.gov/pubmed/22223895
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-1268020	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1268020
Reactome	R-HSA-5205685	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5205685
RefSeq	NP_064628	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_064628
STRING	9606.ENSP00000216034	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000216034&targetmode=cogs
UCSC	uc003awe	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003awe&org=rat
UniGene	Hs.595072	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.595072
UniProtKB	TOM22_HUMAN	http://www.uniprot.org/uniprot/TOM22_HUMAN
UniProtKB-AC	Q9NS69	http://www.uniprot.org/uniprot/Q9NS69
charge	swissprot:TOM22_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TOM22_HUMAN
eggNOG	ENOG41122K3	http://eggnogapi.embl.de/nog_data/html/tree/ENOG41122K3
eggNOG	KOG4111	http://eggnogapi.embl.de/nog_data/html/tree/KOG4111
epestfind	swissprot:TOM22_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TOM22_HUMAN
garnier	swissprot:TOM22_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TOM22_HUMAN
helixturnhelix	swissprot:TOM22_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TOM22_HUMAN
hmoment	swissprot:TOM22_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TOM22_HUMAN
iep	swissprot:TOM22_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TOM22_HUMAN
inforesidue	swissprot:TOM22_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TOM22_HUMAN
neXtProt	NX_Q9NS69	http://www.nextprot.org/db/entry/NX_Q9NS69
octanol	swissprot:TOM22_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TOM22_HUMAN
pepcoil	swissprot:TOM22_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TOM22_HUMAN
pepdigest	swissprot:TOM22_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TOM22_HUMAN
pepinfo	swissprot:TOM22_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TOM22_HUMAN
pepnet	swissprot:TOM22_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TOM22_HUMAN
pepstats	swissprot:TOM22_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TOM22_HUMAN
pepwheel	swissprot:TOM22_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TOM22_HUMAN
pepwindow	swissprot:TOM22_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TOM22_HUMAN
sigcleave	swissprot:TOM22_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TOM22_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	RAMP2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O60895-1; Sequence=Displayed; Name=2; IsoId=O60895-2; Sequence=VSP_055838; 
# AltName	RAMP2_HUMAN	Calcitonin-receptor-like receptor activity-modifying protein 2
# CCDS	CCDS11437	-. [O60895-1]
# ChiTaRS	RAMP2	human
# DrugBank	DB01278	Pramlintide
# Ensembl	ENST00000253796	ENSP00000253796; ENSG00000131477. [O60895-1]
# Ensembl	ENST00000587142	ENSP00000466455; ENSG00000131477. [O60895-2]
# ExpressionAtlas	O60895	baseline and differential
# FUNCTION	RAMP2_HUMAN	Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. {ECO 0000269|PubMed 22102369, ECO 0000269|PubMed 9620797}. 
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005764	lysosome; TAS:ProtInc.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0005905	clathrin-coated pit; TAS:ProtInc.
# GO_component	GO:0009986	cell surface; IDA:UniProtKB.
# GO_component	GO:0043235	receptor complex; IDA:UniProtKB.
# GO_function	GO:0008565	protein transporter activity; IDA:UniProtKB.
# GO_function	GO:0015026	coreceptor activity; ISS:UniProtKB.
# GO_process	GO:0001525	angiogenesis; IDA:UniProtKB.
# GO_process	GO:0001570	vasculogenesis; IMP:UniProtKB.
# GO_process	GO:0001666	response to hypoxia; IEA:Ensembl.
# GO_process	GO:0002040	sprouting angiogenesis; ISS:UniProtKB.
# GO_process	GO:0006171	cAMP biosynthetic process; IDA:UniProtKB.
# GO_process	GO:0006816	calcium ion transport; IDA:UniProtKB.
# GO_process	GO:0006886	intracellular protein transport; IEA:InterPro.
# GO_process	GO:0007186	G-protein coupled receptor signaling pathway; IEA:Ensembl.
# GO_process	GO:0007507	heart development; ISS:UniProtKB.
# GO_process	GO:0007565	female pregnancy; IEA:Ensembl.
# GO_process	GO:0008217	regulation of blood pressure; ISS:UniProtKB.
# GO_process	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway; IEA:InterPro.
# GO_process	GO:0010628	positive regulation of gene expression; IDA:UniProtKB.
# GO_process	GO:0015031	protein transport; IDA:UniProtKB.
# GO_process	GO:0030819	positive regulation of cAMP biosynthetic process; IGI:UniProtKB.
# GO_process	GO:0031623	receptor internalization; IDA:UniProtKB.
# GO_process	GO:0032355	response to estradiol; IEA:Ensembl.
# GO_process	GO:0032570	response to progesterone; IEA:Ensembl.
# GO_process	GO:0032870	cellular response to hormone stimulus; IEA:Ensembl.
# GO_process	GO:0034333	adherens junction assembly; IDA:UniProtKB.
# GO_process	GO:0035924	cellular response to vascular endothelial growth factor stimulus; ISS:UniProtKB.
# GO_process	GO:0043116	negative regulation of vascular permeability; IDA:UniProtKB.
# GO_process	GO:0045766	positive regulation of angiogenesis; ISS:UniProtKB.
# GO_process	GO:0070830	bicellular tight junction assembly; IDA:UniProtKB.
# GO_process	GO:0070831	basement membrane assembly; ISS:UniProtKB.
# GO_process	GO:0072659	protein localization to plasma membrane; IDA:UniProtKB.
# GO_process	GO:0097084	vascular smooth muscle cell development; ISS:UniProtKB.
# GO_process	GO:2000352	negative regulation of endothelial cell apoptotic process; IDA:UniProtKB.
# GO_process	GO:2001214	positive regulation of vasculogenesis; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005764	lysosome
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0003013	circulatory system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007009	plasma membrane organization
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0022607	cellular component assembly
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0030198	extracellular matrix organization
# GOslim_process	GO:0034330	cell junction organization
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0048646	anatomical structure formation involved in morphogenesis
# GOslim_process	GO:0048856	anatomical structure development
# Genevisible	O60895	HS
# HGNC	HGNC:9844	RAMP2
# INTERACTION	RAMP2_HUMAN	Q16602 CALCRL; NbExp=6; IntAct=EBI-9009040, EBI-962878; 
# InterPro	IPR006985	RAMP
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04030	 G protein-coupled receptors
# KEGG_Pathway	ko04270	Vascular smooth muscle contraction
# MIM	605154	gene
# Organism	RAMP2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR14076	PTHR14076
# PDB	2XVT	X-ray; 2.05 A; A/B/C/D/E/F=48-139
# PDB	3AQE	X-ray; 2.00 A; A/B/C/D/E/F=56-139
# PDB	3AQF	X-ray; 2.60 A; A=56-139
# PDB	4RWF	X-ray; 1.76 A; A=55-138
# Pfam	PF04901	RAMP
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-418555	G alpha (s) signalling events
# Reactome	R-HSA-419812	Calcitonin-like ligand receptors
# RecName	RAMP2_HUMAN	Receptor activity-modifying protein 2
# RefSeq	NP_005845	NM_005854.2. [O60895-1]
# SIMILARITY	Belongs to the RAMP family. {ECO	0000305}.
# SUBCELLULAR LOCATION	RAMP2_HUMAN	Membrane; Single-pass type I membrane protein. 
# SUBUNIT	Heterodimer of CALCRL and RAMP2. {ECO	0000250}. 
# TISSUE SPECIFICITY	Strongly expressed in lung, breast, immune system and fetal tissues. {ECO:0000269|PubMed	9620797}. 
# UCSC	uc002ibg	human. [O60895-1]
# eggNOG	ENOG410IYPR	Eukaryota
# eggNOG	ENOG4112A9G	LUCA
BLAST	swissprot:RAMP2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:RAMP2_HUMAN
BioCyc	ZFISH:ENSG00000131477-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000131477-MONOMER
COXPRESdb	10266	http://coxpresdb.jp/data/gene/10266.shtml
CleanEx	HS_RAMP2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_RAMP2
DOI	10.1002/pro.2003	http://dx.doi.org/10.1002/pro.2003
DOI	10.1038/30666	http://dx.doi.org/10.1038/30666
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB01278	http://www.drugbank.ca/drugs/DB01278
EMBL	AC100793	http://www.ebi.ac.uk/ena/data/view/AC100793
EMBL	AJ001015	http://www.ebi.ac.uk/ena/data/view/AJ001015
EMBL	AY265458	http://www.ebi.ac.uk/ena/data/view/AY265458
EMBL	BC027975	http://www.ebi.ac.uk/ena/data/view/BC027975
EMBL	EF687002	http://www.ebi.ac.uk/ena/data/view/EF687002
Ensembl	ENST00000253796	http://www.ensembl.org/id/ENST00000253796
Ensembl	ENST00000587142	http://www.ensembl.org/id/ENST00000587142
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005905	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005905
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0043235	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043235
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0015026	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015026
GO_process	GO:0001525	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001525
GO_process	GO:0001570	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001570
GO_process	GO:0001666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001666
GO_process	GO:0002040	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002040
GO_process	GO:0006171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006171
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0006886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006886
GO_process	GO:0007186	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007186
GO_process	GO:0007507	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007507
GO_process	GO:0007565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007565
GO_process	GO:0008217	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008217
GO_process	GO:0008277	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008277
GO_process	GO:0010628	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010628
GO_process	GO:0015031	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031
GO_process	GO:0030819	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030819
GO_process	GO:0031623	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031623
GO_process	GO:0032355	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032355
GO_process	GO:0032570	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032570
GO_process	GO:0032870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032870
GO_process	GO:0034333	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034333
GO_process	GO:0035924	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035924
GO_process	GO:0043116	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043116
GO_process	GO:0045766	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045766
GO_process	GO:0070830	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070830
GO_process	GO:0070831	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070831
GO_process	GO:0072659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072659
GO_process	GO:0097084	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097084
GO_process	GO:2000352	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000352
GO_process	GO:2001214	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001214
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0003013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003013
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007009
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0022607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0030198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030198
GOslim_process	GO:0034330	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034330
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0048646	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048646
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GeneCards	RAMP2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=RAMP2
GeneID	10266	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10266
GeneTree	ENSGT00390000016200	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000016200
HGNC	HGNC:9844	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:9844
HOGENOM	HOG000230963	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230963&db=HOGENOM6
HOVERGEN	HBG067366	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG067366&db=HOVERGEN
InParanoid	O60895	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O60895
IntAct	O60895	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O60895*
InterPro	IPR006985	http://www.ebi.ac.uk/interpro/entry/IPR006985
Jabion	10266	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10266
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04030	http://www.genome.jp/dbget-bin/www_bget?ko04030
KEGG_Gene	hsa:10266	http://www.genome.jp/dbget-bin/www_bget?hsa:10266
KEGG_Orthology	KO:K08448	http://www.genome.jp/dbget-bin/www_bget?KO:K08448
KEGG_Pathway	ko04270	http://www.genome.jp/kegg-bin/show_pathway?ko04270
MIM	605154	http://www.ncbi.nlm.nih.gov/omim/605154
OMA	DLGFPNP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DLGFPNP
OrthoDB	EOG091G0RMZ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0RMZ
PANTHER	PTHR14076	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14076
PDB	2XVT	http://www.ebi.ac.uk/pdbe-srv/view/entry/2XVT
PDB	3AQE	http://www.ebi.ac.uk/pdbe-srv/view/entry/3AQE
PDB	3AQF	http://www.ebi.ac.uk/pdbe-srv/view/entry/3AQF
PDB	4RWF	http://www.ebi.ac.uk/pdbe-srv/view/entry/4RWF
PDBsum	2XVT	http://www.ebi.ac.uk/pdbsum/2XVT
PDBsum	3AQE	http://www.ebi.ac.uk/pdbsum/3AQE
PDBsum	3AQF	http://www.ebi.ac.uk/pdbsum/3AQF
PDBsum	4RWF	http://www.ebi.ac.uk/pdbsum/4RWF
PSORT	swissprot:RAMP2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:RAMP2_HUMAN
PSORT-B	swissprot:RAMP2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:RAMP2_HUMAN
PSORT2	swissprot:RAMP2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:RAMP2_HUMAN
Pfam	PF04901	http://pfam.xfam.org/family/PF04901
PharmGKB	PA34203	http://www.pharmgkb.org/do/serve?objId=PA34203&objCls=Gene
Phobius	swissprot:RAMP2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:RAMP2_HUMAN
PhylomeDB	O60895	http://phylomedb.org/?seqid=O60895
ProteinModelPortal	O60895	http://www.proteinmodelportal.org/query/uniprot/O60895
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	22102369	http://www.ncbi.nlm.nih.gov/pubmed/22102369
PubMed	9620797	http://www.ncbi.nlm.nih.gov/pubmed/9620797
Reactome	R-HSA-418555	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418555
Reactome	R-HSA-419812	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-419812
RefSeq	NP_005845	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005845
SMR	O60895	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O60895
STRING	9606.ENSP00000253796	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000253796&targetmode=cogs
UCSC	uc002ibg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ibg&org=rat
UniGene	Hs.514193	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.514193
UniProtKB	RAMP2_HUMAN	http://www.uniprot.org/uniprot/RAMP2_HUMAN
UniProtKB-AC	O60895	http://www.uniprot.org/uniprot/O60895
charge	swissprot:RAMP2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:RAMP2_HUMAN
eggNOG	ENOG410IYPR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IYPR
eggNOG	ENOG4112A9G	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4112A9G
epestfind	swissprot:RAMP2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:RAMP2_HUMAN
garnier	swissprot:RAMP2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:RAMP2_HUMAN
helixturnhelix	swissprot:RAMP2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:RAMP2_HUMAN
hmoment	swissprot:RAMP2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:RAMP2_HUMAN
iep	swissprot:RAMP2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:RAMP2_HUMAN
inforesidue	swissprot:RAMP2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:RAMP2_HUMAN
neXtProt	NX_O60895	http://www.nextprot.org/db/entry/NX_O60895
octanol	swissprot:RAMP2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:RAMP2_HUMAN
pepcoil	swissprot:RAMP2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:RAMP2_HUMAN
pepdigest	swissprot:RAMP2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:RAMP2_HUMAN
pepinfo	swissprot:RAMP2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:RAMP2_HUMAN
pepnet	swissprot:RAMP2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:RAMP2_HUMAN
pepstats	swissprot:RAMP2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:RAMP2_HUMAN
pepwheel	swissprot:RAMP2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:RAMP2_HUMAN
pepwindow	swissprot:RAMP2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:RAMP2_HUMAN
sigcleave	swissprot:RAMP2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:RAMP2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=KCC2a; IsoId=Q9H2X9-1; Sequence=Displayed; Name=2; Synonyms=KCC2b; IsoId=Q9H2X9-2; Sequence=VSP_029909; Note=Ref.1 (AAG43493) sequence is in conflict in position: 2	L->P. {ECO:0000305}; 
# AltName	S12A5_HUMAN	Electroneutral potassium-chloride cotransporter 2
# AltName	S12A5_HUMAN	K-Cl cotransporter 2
# AltName	S12A5_HUMAN	Neuronal K-Cl cotransporter
# BioGrid	121538	2
# CCDS	CCDS13391	-. [Q9H2X9-2]
# CCDS	CCDS46610	-. [Q9H2X9-1]
# DISEASE	S12A5_HUMAN	Epilepsy, idiopathic generalized 14 (EIG14) [MIM 616685]  An autosomal dominant form of idiopathic generalized epilepsy, a disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. Seizure types include juvenile myoclonic seizures, absence seizures, and generalized tonic-clonic seizures. {ECO 0000269|PubMed 24668262, ECO 0000269|PubMed 24928908, ECO 0000269|PubMed 26528127}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# DISEASE	S12A5_HUMAN	Epileptic encephalopathy, early infantile, 34 (EIEE34) [MIM 616645]  A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. EIEE34 is characterized by onset of refractory migrating focal seizures in infancy. Affected children show developmental regression and are severely impaired globally. {ECO 0000269|PubMed 26333769}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00761	Potassium Chloride
# DrugBank	DB00887	Bumetanide
# ENZYME REGULATION	Inhibited by WNK3. {ECO:0000269|PubMed	21613606}. 
# Ensembl	ENST00000243964	ENSP00000243964; ENSG00000124140. [Q9H2X9-2]
# Ensembl	ENST00000454036	ENSP00000387694; ENSG00000124140. [Q9H2X9-1]
# ExpressionAtlas	Q9H2X9	baseline and differential
# FUNCTION	S12A5_HUMAN	Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation (PubMed 24668262). {ECO 0000250|UniProtKB Q63633, ECO 0000269|PubMed 24668262}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IEA:InterPro.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0043025	neuronal cell body; IEA:Ensembl.
# GO_component	GO:0043198	dendritic shaft; IEA:Ensembl.
# GO_function	GO:0015108	chloride transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0019901	protein kinase binding; IPI:ParkinsonsUK-UCL.
# GO_function	GO:0022820	potassium ion symporter activity; IBA:GO_Central.
# GO_function	S12A5_HUMAN	GO 0015379 potassium chloride symporter activity; NAS UniProtKB.
# GO_process	GO:0006810	transport; NAS:UniProtKB.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006873	cellular ion homeostasis; NAS:UniProtKB.
# GO_process	GO:0007268	chemical synaptic transmission; IBA:GO_Central.
# GO_process	GO:0007612	learning; IEA:Ensembl.
# GO_process	GO:0030644	cellular chloride ion homeostasis; IDA:UniProtKB.
# GO_process	GO:0035264	multicellular organism growth; IEA:Ensembl.
# GO_process	GO:0040040	thermosensory behavior; IEA:Ensembl.
# GO_process	GO:0042493	response to drug; IEA:Ensembl.
# GO_process	GO:0060996	dendritic spine development; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0040007	growth
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# Genevisible	Q9H2X9	HS
# HGNC	HGNC:13818	SLC12A5
# InterPro	IPR000076	KCL_cotranspt
# InterPro	IPR004841	AA-permease/SLC12A_dom
# InterPro	IPR004842	SLC12A_fam
# InterPro	IPR018491	SLC12_C
# InterPro	IPR030358	KCC2
# KEGG_Brite	ko02001	Solute carrier family
# MIM	606726	gene
# MIM	616645	phenotype
# MIM	616685	phenotype
# MISCELLANEOUS	S12A5_HUMAN	Inhibited by furosemide and bumetanide. 
# Organism	S12A5_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11827:SF54	PTHR11827:SF54; 4
# PRINTS	PR01081	KCLTRNSPORT
# Pfam	PF00324	AA_permease; 2
# Pfam	PF03522	SLC12; 3
# Proteomes	UP000005640	Chromosome 20
# Reactome	R-HSA-426117	Cation-coupled Chloride cotransporters
# RecName	S12A5_HUMAN	Solute carrier family 12 member 5
# RefSeq	NP_001128243	NM_001134771.1. [Q9H2X9-1]
# RefSeq	NP_065759	NM_020708.4. [Q9H2X9-2]
# SIMILARITY	Belongs to the SLC12A transporter family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S12A5_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Homomultimer and heteromultimer with other K-Cl cotransporters. Interacts with AP2A1 (By similarity). {ECO	0000250}. 
# TCDB	2.A.30.5	the cation-chloride cotransporter (ccc) family
# TIGRFAMs	TIGR00930	2a30
# TISSUE SPECIFICITY	S12A5_HUMAN	Brain specific. Detected in neuronal cells. 
# UCSC	uc002xrb	human. [Q9H2X9-1]
# eggNOG	COG0531	LUCA
# eggNOG	KOG2082	Eukaryota
BLAST	swissprot:S12A5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S12A5_HUMAN
BioCyc	ZFISH:ENSG00000124140-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000124140-MONOMER
COXPRESdb	57468	http://coxpresdb.jp/data/gene/57468.shtml
CleanEx	HS_SLC12A5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC12A5
DOI	10.1002/embr.201438749	http://dx.doi.org/10.1002/embr.201438749
DOI	10.1016/S0169-328X(02)00190-0	http://dx.doi.org/10.1016/S0169-328X(02)00190-0
DOI	10.1038/414865a	http://dx.doi.org/10.1038/414865a
DOI	10.1038/ncomms9038	http://dx.doi.org/10.1038/ncomms9038
DOI	10.1093/dnares/6.5.329	http://dx.doi.org/10.1093/dnares/6.5.329
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1101/gr.4039406	http://dx.doi.org/10.1101/gr.4039406
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1152/ajpcell.00070.2011	http://dx.doi.org/10.1152/ajpcell.00070.2011
DOI	10.15252/embr.201438840	http://dx.doi.org/10.15252/embr.201438840
DOI	10.3389/fncel.2015.00386	http://dx.doi.org/10.3389/fncel.2015.00386
DrugBank	DB00761	http://www.drugbank.ca/drugs/DB00761
DrugBank	DB00887	http://www.drugbank.ca/drugs/DB00887
EMBL	AB033002	http://www.ebi.ac.uk/ena/data/view/AB033002
EMBL	AF208159	http://www.ebi.ac.uk/ena/data/view/AF208159
EMBL	AL162458	http://www.ebi.ac.uk/ena/data/view/AL162458
EMBL	BC132668	http://www.ebi.ac.uk/ena/data/view/BC132668
EMBL	BC132670	http://www.ebi.ac.uk/ena/data/view/BC132670
EMBL	DA102113	http://www.ebi.ac.uk/ena/data/view/DA102113
EMBL	DA328785	http://www.ebi.ac.uk/ena/data/view/DA328785
Ensembl	ENST00000243964	http://www.ensembl.org/id/ENST00000243964
Ensembl	ENST00000454036	http://www.ensembl.org/id/ENST00000454036
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0043198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043198
GO_function	GO:0015108	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015108
GO_function	GO:0015379	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015379
GO_function	GO:0019901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019901
GO_function	GO:0022820	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022820
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006873	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006873
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007612	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007612
GO_process	GO:0030644	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030644
GO_process	GO:0035264	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035264
GO_process	GO:0040040	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040040
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0060996	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060996
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0040007	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040007
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	SLC12A5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC12A5
GeneID	57468	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57468
GeneTree	ENSGT00760000119053	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119053
HGNC	HGNC:13818	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13818
HOGENOM	HOG000092644	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000092644&db=HOGENOM6
HOVERGEN	HBG052852	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052852&db=HOVERGEN
HPA	HPA072058	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA072058
InParanoid	Q9H2X9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9H2X9
InterPro	IPR000076	http://www.ebi.ac.uk/interpro/entry/IPR000076
InterPro	IPR004841	http://www.ebi.ac.uk/interpro/entry/IPR004841
InterPro	IPR004842	http://www.ebi.ac.uk/interpro/entry/IPR004842
InterPro	IPR018491	http://www.ebi.ac.uk/interpro/entry/IPR018491
InterPro	IPR030358	http://www.ebi.ac.uk/interpro/entry/IPR030358
Jabion	57468	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=57468
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:57468	http://www.genome.jp/dbget-bin/www_bget?hsa:57468
KEGG_Orthology	KO:K14427	http://www.genome.jp/dbget-bin/www_bget?KO:K14427
MIM	606726	http://www.ncbi.nlm.nih.gov/omim/606726
MIM	616645	http://www.ncbi.nlm.nih.gov/omim/616645
MIM	616685	http://www.ncbi.nlm.nih.gov/omim/616685
OMA	GWPRNWR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GWPRNWR
OrthoDB	EOG091G0WB4	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0WB4
PANTHER	PTHR11827:SF54	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11827:SF54
PRINTS	PR01081	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01081
PSORT	swissprot:S12A5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S12A5_HUMAN
PSORT-B	swissprot:S12A5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S12A5_HUMAN
PSORT2	swissprot:S12A5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S12A5_HUMAN
Pfam	PF00324	http://pfam.xfam.org/family/PF00324
Pfam	PF03522	http://pfam.xfam.org/family/PF03522
PharmGKB	PA37814	http://www.pharmgkb.org/do/serve?objId=PA37814&objCls=Gene
Phobius	swissprot:S12A5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S12A5_HUMAN
PhylomeDB	Q9H2X9	http://phylomedb.org/?seqid=Q9H2X9
ProteinModelPortal	Q9H2X9	http://www.proteinmodelportal.org/query/uniprot/Q9H2X9
PubMed	10574461	http://www.ncbi.nlm.nih.gov/pubmed/10574461
PubMed	11780052	http://www.ncbi.nlm.nih.gov/pubmed/11780052
PubMed	12106695	http://www.ncbi.nlm.nih.gov/pubmed/12106695
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16344560	http://www.ncbi.nlm.nih.gov/pubmed/16344560
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	21613606	http://www.ncbi.nlm.nih.gov/pubmed/21613606
PubMed	24668262	http://www.ncbi.nlm.nih.gov/pubmed/24668262
PubMed	24928908	http://www.ncbi.nlm.nih.gov/pubmed/24928908
PubMed	26333769	http://www.ncbi.nlm.nih.gov/pubmed/26333769
PubMed	26528127	http://www.ncbi.nlm.nih.gov/pubmed/26528127
Reactome	R-HSA-426117	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-426117
RefSeq	NP_001128243	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001128243
RefSeq	NP_065759	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_065759
STRING	9606.ENSP00000387694	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000387694&targetmode=cogs
TCDB	2.A.30.5	http://www.tcdb.org/search/result.php?tc=2.A.30.5
TIGRFAMs	TIGR00930	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00930
UCSC	uc002xrb	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002xrb&org=rat
UniGene	Hs.21413	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.21413
UniProtKB	S12A5_HUMAN	http://www.uniprot.org/uniprot/S12A5_HUMAN
UniProtKB-AC	Q9H2X9	http://www.uniprot.org/uniprot/Q9H2X9
charge	swissprot:S12A5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S12A5_HUMAN
eggNOG	COG0531	http://eggnogapi.embl.de/nog_data/html/tree/COG0531
eggNOG	KOG2082	http://eggnogapi.embl.de/nog_data/html/tree/KOG2082
epestfind	swissprot:S12A5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S12A5_HUMAN
garnier	swissprot:S12A5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S12A5_HUMAN
helixturnhelix	swissprot:S12A5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S12A5_HUMAN
hmoment	swissprot:S12A5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S12A5_HUMAN
iep	swissprot:S12A5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S12A5_HUMAN
inforesidue	swissprot:S12A5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S12A5_HUMAN
neXtProt	NX_Q9H2X9	http://www.nextprot.org/db/entry/NX_Q9H2X9
octanol	swissprot:S12A5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S12A5_HUMAN
pepcoil	swissprot:S12A5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S12A5_HUMAN
pepdigest	swissprot:S12A5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S12A5_HUMAN
pepinfo	swissprot:S12A5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S12A5_HUMAN
pepnet	swissprot:S12A5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S12A5_HUMAN
pepstats	swissprot:S12A5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S12A5_HUMAN
pepwheel	swissprot:S12A5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S12A5_HUMAN
pepwindow	swissprot:S12A5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S12A5_HUMAN
sigcleave	swissprot:S12A5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S12A5_HUMAN
## Database	ID	URL or Descriptions
# AltName	ATOX1_HUMAN	Metal transport protein ATX1
# BioGrid	106965	13
# CDD	cd00371	HMA
# ChiTaRS	ATOX1	human
# Ensembl	ENST00000313115	ENSP00000316854; ENSG00000177556
# Ensembl	ENST00000522710	ENSP00000429814; ENSG00000177556
# Ensembl	ENST00000524142	ENSP00000430598; ENSG00000177556
# ExpressionAtlas	O00244	baseline and differential
# FUNCTION	ATOX1_HUMAN	Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense. 
# GO_component	GO:0005829	cytosol; TAS:UniProtKB.
# GO_function	GO:0005375	copper ion transmembrane transporter activity; IEA:Ensembl.
# GO_function	GO:0005507	copper ion binding; IDA:UniProtKB.
# GO_function	GO:0016530	metallochaperone activity; TAS:UniProtKB.
# GO_function	GO:0016531	copper chaperone activity; IDA:UniProtKB.
# GO_function	GO:0032767	copper-dependent protein binding; IPI:UniProtKB.
# GO_process	GO:0006825	copper ion transport; TAS:UniProtKB.
# GO_process	GO:0006878	cellular copper ion homeostasis; TAS:ProtInc.
# GO_process	GO:0006979	response to oxidative stress; TAS:ProtInc.
# GO_process	GO:0015680	intracellular copper ion transport; IBA:GO_Central.
# GOslim_component	GO:0005829	cytosol
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0042592	homeostatic process
# Genevisible	O00244	HS
# HGNC	HGNC:798	ATOX1
# INTERACTION	ATOX1_HUMAN	O43822 C21orf2; NbExp=3; IntAct=EBI-10179267, EBI-2835332; Q9NWS6 FAM118A; NbExp=5; IntAct=EBI-10179267, EBI-8638992; O95749 GGPS1; NbExp=3; IntAct=EBI-10179267, EBI-10179283; 
# IntAct	O00244	5
# InterPro	IPR006121	HMA_dom
# InterPro	IPR017969	Heavy-metal-associated_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Pathway	ko04978	Mineral absorption
# MIM	602270	gene
# Organism	ATOX1_HUMAN	Homo sapiens (Human)
# PDB	1FE0	X-ray; 1.75 A; A/B=1-68
# PDB	1FE4	X-ray; 1.75 A; A/B=1-68
# PDB	1FEE	X-ray; 1.80 A; A/B=1-68
# PDB	1TL4	NMR; -; A=1-68
# PDB	1TL5	NMR; -; A=1-68
# PDB	2K1R	NMR; -; B=1-68
# PDB	2LQ9	NMR; -; A=1-68
# PDB	3CJK	X-ray; 1.80 A; A=2-68
# PDB	3IWL	X-ray; 1.60 A; A=1-68
# PDB	3IWX	X-ray; 2.14 A; A/B=1-68
# PDB	4QOT	X-ray; 2.20 A; A/B=1-68
# PDB	4YDX	X-ray; 1.60 A; A=2-68
# PDB	4YEA	X-ray; 2.14 A; A/B=2-68
# PDB	5T7L	X-ray; 2.83 A; A=2-68
# PROSITE	PS01047	HMA_1
# PROSITE	PS50846	HMA_2
# Pfam	PF00403	HMA
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-3299685	Detoxification of Reactive Oxygen Species
# Reactome	R-HSA-6803544	Ion influx/efflux at host-pathogen interface
# RecName	ATOX1_HUMAN	Copper transport protein ATOX1
# RefSeq	NP_004036	NM_004045.3
# SIMILARITY	Belongs to the ATX1 family. {ECO	0000305}. 
# SIMILARITY	Contains 1 HMA domain. {ECO:0000255|PROSITE- ProRule	PRU00280}. 
# SUBUNIT	ATOX1_HUMAN	Interacts with ATP7B (PubMed 10966647). Interacts with ATP7A (PubMed 21667063). {ECO 0000269|PubMed 10966647, ECO 0000269|PubMed 21667063}. 
# SUPFAM	SSF55008	SSF55008
# TISSUE SPECIFICITY	ATOX1_HUMAN	Ubiquitous. 
# UCSC	uc003luk	human
# WEB RESOURCE	ATOX1_HUMAN	Name=NIEHS-SNPs; URL="http //egp.gs.washington.edu/data/atox1/";
# eggNOG	COG2608	LUCA
# eggNOG	KOG1603	Eukaryota
BLAST	swissprot:ATOX1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ATOX1_HUMAN
BioCyc	ZFISH:ENSG00000177556-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000177556-MONOMER
COG	COG2608	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2608
COXPRESdb	475	http://coxpresdb.jp/data/gene/475.shtml
CleanEx	HS_ATOX1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATOX1
DOI	10.1007/s00018-011-0743-1	http://dx.doi.org/10.1007/s00018-011-0743-1
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/78999	http://dx.doi.org/10.1038/78999
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.272.14.9221	http://dx.doi.org/10.1074/jbc.272.14.9221
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1186/1471-2156-4-4	http://dx.doi.org/10.1186/1471-2156-4-4
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AK293063	http://www.ebi.ac.uk/ena/data/view/AK293063
EMBL	AY165037	http://www.ebi.ac.uk/ena/data/view/AY165037
EMBL	AY986502	http://www.ebi.ac.uk/ena/data/view/AY986502
EMBL	BC112248	http://www.ebi.ac.uk/ena/data/view/BC112248
EMBL	BC112250	http://www.ebi.ac.uk/ena/data/view/BC112250
EMBL	BT009786	http://www.ebi.ac.uk/ena/data/view/BT009786
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	U70660	http://www.ebi.ac.uk/ena/data/view/U70660
Ensembl	ENST00000313115	http://www.ensembl.org/id/ENST00000313115
Ensembl	ENST00000522710	http://www.ensembl.org/id/ENST00000522710
Ensembl	ENST00000524142	http://www.ensembl.org/id/ENST00000524142
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_function	GO:0005375	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005375
GO_function	GO:0005507	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005507
GO_function	GO:0016530	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016530
GO_function	GO:0016531	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016531
GO_function	GO:0032767	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032767
GO_process	GO:0006825	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006825
GO_process	GO:0006878	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006878
GO_process	GO:0006979	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979
GO_process	GO:0015680	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015680
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GeneCards	ATOX1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATOX1
GeneID	475	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=475
GeneTree	ENSGT00390000005805	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000005805
HGNC	HGNC:798	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:798
HOGENOM	HOG000038877	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000038877&db=HOGENOM6
HOVERGEN	HBG050610	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050610&db=HOVERGEN
HPA	HPA055036	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA055036
InParanoid	O00244	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O00244
IntAct	O00244	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O00244*
InterPro	IPR006121	http://www.ebi.ac.uk/interpro/entry/IPR006121
InterPro	IPR017969	http://www.ebi.ac.uk/interpro/entry/IPR017969
Jabion	475	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=475
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Gene	hsa:475	http://www.genome.jp/dbget-bin/www_bget?hsa:475
KEGG_Orthology	KO:K07213	http://www.genome.jp/dbget-bin/www_bget?KO:K07213
KEGG_Pathway	ko04978	http://www.genome.jp/kegg-bin/show_pathway?ko04978
MIM	602270	http://www.ncbi.nlm.nih.gov/omim/602270
MINT	MINT-105921	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-105921
PDB	1FE0	http://www.ebi.ac.uk/pdbe-srv/view/entry/1FE0
PDB	1FE4	http://www.ebi.ac.uk/pdbe-srv/view/entry/1FE4
PDB	1FEE	http://www.ebi.ac.uk/pdbe-srv/view/entry/1FEE
PDB	1TL4	http://www.ebi.ac.uk/pdbe-srv/view/entry/1TL4
PDB	1TL5	http://www.ebi.ac.uk/pdbe-srv/view/entry/1TL5
PDB	2K1R	http://www.ebi.ac.uk/pdbe-srv/view/entry/2K1R
PDB	2LQ9	http://www.ebi.ac.uk/pdbe-srv/view/entry/2LQ9
PDB	3CJK	http://www.ebi.ac.uk/pdbe-srv/view/entry/3CJK
PDB	3IWL	http://www.ebi.ac.uk/pdbe-srv/view/entry/3IWL
PDB	3IWX	http://www.ebi.ac.uk/pdbe-srv/view/entry/3IWX
PDB	4QOT	http://www.ebi.ac.uk/pdbe-srv/view/entry/4QOT
PDB	4YDX	http://www.ebi.ac.uk/pdbe-srv/view/entry/4YDX
PDB	4YEA	http://www.ebi.ac.uk/pdbe-srv/view/entry/4YEA
PDB	5T7L	http://www.ebi.ac.uk/pdbe-srv/view/entry/5T7L
PDBsum	1FE0	http://www.ebi.ac.uk/pdbsum/1FE0
PDBsum	1FE4	http://www.ebi.ac.uk/pdbsum/1FE4
PDBsum	1FEE	http://www.ebi.ac.uk/pdbsum/1FEE
PDBsum	1TL4	http://www.ebi.ac.uk/pdbsum/1TL4
PDBsum	1TL5	http://www.ebi.ac.uk/pdbsum/1TL5
PDBsum	2K1R	http://www.ebi.ac.uk/pdbsum/2K1R
PDBsum	2LQ9	http://www.ebi.ac.uk/pdbsum/2LQ9
PDBsum	3CJK	http://www.ebi.ac.uk/pdbsum/3CJK
PDBsum	3IWL	http://www.ebi.ac.uk/pdbsum/3IWL
PDBsum	3IWX	http://www.ebi.ac.uk/pdbsum/3IWX
PDBsum	4QOT	http://www.ebi.ac.uk/pdbsum/4QOT
PDBsum	4YDX	http://www.ebi.ac.uk/pdbsum/4YDX
PDBsum	4YEA	http://www.ebi.ac.uk/pdbsum/4YEA
PDBsum	5T7L	http://www.ebi.ac.uk/pdbsum/5T7L
PROSITE	PS01047	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01047
PROSITE	PS50846	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50846
PSORT	swissprot:ATOX1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ATOX1_HUMAN
PSORT-B	swissprot:ATOX1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ATOX1_HUMAN
PSORT2	swissprot:ATOX1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ATOX1_HUMAN
Pfam	PF00403	http://pfam.xfam.org/family/PF00403
PharmGKB	PA25096	http://www.pharmgkb.org/do/serve?objId=PA25096&objCls=Gene
Phobius	swissprot:ATOX1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ATOX1_HUMAN
PhylomeDB	O00244	http://phylomedb.org/?seqid=O00244
ProteinModelPortal	O00244	http://www.proteinmodelportal.org/query/uniprot/O00244
PubMed	10966647	http://www.ncbi.nlm.nih.gov/pubmed/10966647
PubMed	12594858	http://www.ncbi.nlm.nih.gov/pubmed/12594858
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21667063	http://www.ncbi.nlm.nih.gov/pubmed/21667063
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	9083055	http://www.ncbi.nlm.nih.gov/pubmed/9083055
Reactome	R-HSA-3299685	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3299685
Reactome	R-HSA-6803544	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6803544
RefSeq	NP_004036	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004036
SMR	O00244	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O00244
STRING	9606.ENSP00000316854	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000316854&targetmode=cogs
STRING	COG2608	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2608&targetmode=cogs
SUPFAM	SSF55008	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55008
UCSC	uc003luk	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003luk&org=rat
UniGene	Hs.125213	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.125213
UniProtKB	ATOX1_HUMAN	http://www.uniprot.org/uniprot/ATOX1_HUMAN
UniProtKB-AC	O00244	http://www.uniprot.org/uniprot/O00244
charge	swissprot:ATOX1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ATOX1_HUMAN
eggNOG	COG2608	http://eggnogapi.embl.de/nog_data/html/tree/COG2608
eggNOG	KOG1603	http://eggnogapi.embl.de/nog_data/html/tree/KOG1603
epestfind	swissprot:ATOX1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ATOX1_HUMAN
garnier	swissprot:ATOX1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ATOX1_HUMAN
helixturnhelix	swissprot:ATOX1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATOX1_HUMAN
hmoment	swissprot:ATOX1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ATOX1_HUMAN
iep	swissprot:ATOX1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ATOX1_HUMAN
inforesidue	swissprot:ATOX1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ATOX1_HUMAN
neXtProt	NX_O00244	http://www.nextprot.org/db/entry/NX_O00244
octanol	swissprot:ATOX1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ATOX1_HUMAN
pepcoil	swissprot:ATOX1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ATOX1_HUMAN
pepdigest	swissprot:ATOX1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ATOX1_HUMAN
pepinfo	swissprot:ATOX1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ATOX1_HUMAN
pepnet	swissprot:ATOX1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ATOX1_HUMAN
pepstats	swissprot:ATOX1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ATOX1_HUMAN
pepwheel	swissprot:ATOX1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ATOX1_HUMAN
pepwindow	swissprot:ATOX1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ATOX1_HUMAN
sigcleave	swissprot:ATOX1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ATOX1_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	111805	38
# CAUTION	It is uncertain whether Met-1 or Met-6 is the initiator. {ECO	0000305}. 
# ChiTaRS	RAB4A	human
# Ensembl	ENST00000366690	ENSP00000355651; ENSG00000168118
# ExpressionAtlas	P20338	baseline and differential
# FUNCTION	RAB4A_HUMAN	Protein transport. Probably involved in vesicular traffic (By similarity). {ECO 0000250}. 
# GO_component	GO:0005768	endosome; IBA:GO_Central.
# GO_component	GO:0005829	cytosol; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; IEA:Ensembl.
# GO_component	GO:0031982	vesicle; IDA:UniProtKB.
# GO_component	GO:0032593	insulin-responsive compartment; IBA:GO_Central.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IDA:UniProtKB.
# GO_component	GO:0055037	recycling endosome; IEA:Ensembl.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0001671	ATPase activator activity; IEA:Ensembl.
# GO_function	GO:0003924	GTPase activity; IDA:UniProtKB.
# GO_function	GO:0005525	GTP binding; IDA:UniProtKB.
# GO_function	GO:0008565	protein transporter activity; IEA:Ensembl.
# GO_function	GO:0019003	GDP binding; IDA:UniProtKB.
# GO_process	GO:0019882	antigen processing and presentation; IMP:UniProtKB.
# GO_process	GO:0030100	regulation of endocytosis; IBA:GO_Central.
# GO_process	GO:0032482	Rab protein signal transduction; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003924	GTPase activity
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0030234	enzyme regulator activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# Gene3D	3.40.50.300	-; 1.
# Genevisible	P20338	HS
# HGNC	HGNC:9781	RAB4A
# INTERACTION	RAB4A_HUMAN	Q8IW24 EXOC5; NbExp=3; IntAct=EBI-722284, EBI-10171392; P31150 GDI1; NbExp=3; IntAct=EBI-722284, EBI-946999; P50395 GDI2; NbExp=2; IntAct=EBI-722284, EBI-1049143; Q4V328 GRIPAP1; NbExp=3; IntAct=EBI-722284, EBI-717919; Q8N1B4 VPS52; NbExp=3; IntAct=EBI-722284, EBI-2799833; 
# IntAct	P20338	21
# InterPro	IPR001806	Small_GTPase
# InterPro	IPR005225	Small_GTP-bd_dom
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04031	 GTP-binding proteins
# KEGG_Pathway	ko04144	Endocytosis
# MIM	179511	gene
# Organism	RAB4A_HUMAN	Homo sapiens (Human)
# PDB	1YU9	X-ray; 2.07 A; A=7-177
# PDB	1Z0K	X-ray; 1.92 A; A/C=7-177
# PDB	2BMD	X-ray; 1.80 A; A=6-189
# PDB	2BME	X-ray; 1.57 A; A/B/C/D=6-189
# PIR	E34323	E34323
# PROSITE	PS51419	RAB
# PTM	RAB4A_HUMAN	Phosphorylated by CDK1 kinase during mitosis. {ECO 0000269|PubMed 1425574, ECO 0000269|PubMed 1902553}. 
# Pfam	PF00071	Ras
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-1445148	Translocation of GLUT4 to the plasma membrane
# Reactome	R-HSA-1660499	Synthesis of PIPs at the plasma membrane
# Reactome	R-HSA-8875656	MET receptor recycling
# RecName	RAB4A_HUMAN	Ras-related protein Rab-4A
# RefSeq	NP_001258927	NM_001271998.1
# RefSeq	NP_004569	NM_004578.3
# SEQUENCE CAUTION	Sequence=AAA60244.1; Type=Frameshift; Positions=6; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the small GTPase superfamily. Rab family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	RAB4A_HUMAN	Membrane; Peripheral membrane protein. Cytoplasm. Note=Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1. 
# SUBUNIT	RAB4A_HUMAN	Interacts with SGSM1, SGSM2 and SGSM3 (By similarity). Interacts with RAB11FIP1, RABEP1, ZFYVE20 and RUFY1. Interacts (membrane-bound form) with NDRG1; the interaction involves NDRG1 in vesicular recycling of E-cadherin. Does not interact with HPS4 (By similarity). {ECO 0000250|UniProtKB P56371, ECO 0000269|PubMed 10698684, ECO 0000269|PubMed 11786538, ECO 0000269|PubMed 11788822, ECO 0000269|PubMed 14617813, ECO 0000269|PubMed 15280022, ECO 0000269|PubMed 15907487, ECO 0000269|PubMed 16034420, ECO 0000269|PubMed 17786215}. 
# SUPFAM	SSF52540	SSF52540
# TIGRFAMs	TIGR00231	small_GTP
# UCSC	uc001hth	human
# eggNOG	ENOG410XQ9X	LUCA
# eggNOG	KOG0086	Eukaryota
BLAST	swissprot:RAB4A_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:RAB4A_HUMAN
COXPRESdb	5867	http://coxpresdb.jp/data/gene/5867.shtml
CleanEx	HS_RAB4A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_RAB4A
DIP	DIP-372N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-372N
DOI	10.1016/j.febslet.2004.06.068	http://dx.doi.org/10.1016/j.febslet.2004.06.068
DOI	10.1016/j.febslet.2005.04.020	http://dx.doi.org/10.1016/j.febslet.2005.04.020
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/350715a0	http://dx.doi.org/10.1038/350715a0
DOI	10.1038/nature03798	http://dx.doi.org/10.1038/nature03798
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ncb744	http://dx.doi.org/10.1038/ncb744
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/bj3460593	http://dx.doi.org/10.1042/bj3460593
DOI	10.1074/jbc.M108665200	http://dx.doi.org/10.1074/jbc.M108665200
DOI	10.1074/jbc.M606301200	http://dx.doi.org/10.1074/jbc.M606301200
DOI	10.1091/mbc.E03-05-0343	http://dx.doi.org/10.1091/mbc.E03-05-0343
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1371/journal.pone.0000844	http://dx.doi.org/10.1371/journal.pone.0000844
EMBL	AF498934	http://www.ebi.ac.uk/ena/data/view/AF498934
EMBL	AK313807	http://www.ebi.ac.uk/ena/data/view/AK313807
EMBL	AL117350	http://www.ebi.ac.uk/ena/data/view/AL117350
EMBL	AL117350	http://www.ebi.ac.uk/ena/data/view/AL117350
EMBL	AL162595	http://www.ebi.ac.uk/ena/data/view/AL162595
EMBL	AL162595	http://www.ebi.ac.uk/ena/data/view/AL162595
EMBL	AY585832	http://www.ebi.ac.uk/ena/data/view/AY585832
EMBL	BC002438	http://www.ebi.ac.uk/ena/data/view/BC002438
EMBL	BC004309	http://www.ebi.ac.uk/ena/data/view/BC004309
EMBL	CH471098	http://www.ebi.ac.uk/ena/data/view/CH471098
EMBL	M28211	http://www.ebi.ac.uk/ena/data/view/M28211
Ensembl	ENST00000366690	http://www.ensembl.org/id/ENST00000366690
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0031982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031982
GO_component	GO:0032593	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032593
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_component	GO:0055037	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055037
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0001671	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001671
GO_function	GO:0003924	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924
GO_function	GO:0005525	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0019003	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019003
GO_process	GO:0019882	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019882
GO_process	GO:0030100	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030100
GO_process	GO:0032482	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032482
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003924	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0030234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	RAB4A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=RAB4A
GeneID	5867	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5867
GeneTree	ENSGT00760000118841	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118841
HGNC	HGNC:9781	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:9781
HOVERGEN	HBG009351	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG009351&db=HOVERGEN
HPA	CAB004990	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB004990
InParanoid	P20338	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P20338
IntAct	P20338	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P20338*
InterPro	IPR001806	http://www.ebi.ac.uk/interpro/entry/IPR001806
InterPro	IPR005225	http://www.ebi.ac.uk/interpro/entry/IPR005225
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	5867	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=5867
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04031	http://www.genome.jp/dbget-bin/www_bget?ko04031
KEGG_Gene	hsa:5867	http://www.genome.jp/dbget-bin/www_bget?hsa:5867
KEGG_Orthology	KO:K07879	http://www.genome.jp/dbget-bin/www_bget?KO:K07879
KEGG_Pathway	ko04144	http://www.genome.jp/kegg-bin/show_pathway?ko04144
MIM	179511	http://www.ncbi.nlm.nih.gov/omim/179511
MINT	MINT-1376149	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1376149
OMA	MVKLQIW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MVKLQIW
OrthoDB	EOG091G0QOB	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0QOB
PDB	1YU9	http://www.ebi.ac.uk/pdbe-srv/view/entry/1YU9
PDB	1Z0K	http://www.ebi.ac.uk/pdbe-srv/view/entry/1Z0K
PDB	2BMD	http://www.ebi.ac.uk/pdbe-srv/view/entry/2BMD
PDB	2BME	http://www.ebi.ac.uk/pdbe-srv/view/entry/2BME
PDBsum	1YU9	http://www.ebi.ac.uk/pdbsum/1YU9
PDBsum	1Z0K	http://www.ebi.ac.uk/pdbsum/1Z0K
PDBsum	2BMD	http://www.ebi.ac.uk/pdbsum/2BMD
PDBsum	2BME	http://www.ebi.ac.uk/pdbsum/2BME
PROSITE	PS51419	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51419
PSORT	swissprot:RAB4A_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:RAB4A_HUMAN
PSORT-B	swissprot:RAB4A_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:RAB4A_HUMAN
PSORT2	swissprot:RAB4A_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:RAB4A_HUMAN
Pfam	PF00071	http://pfam.xfam.org/family/PF00071
PharmGKB	PA34141	http://www.pharmgkb.org/do/serve?objId=PA34141&objCls=Gene
Phobius	swissprot:RAB4A_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:RAB4A_HUMAN
PhylomeDB	P20338	http://phylomedb.org/?seqid=P20338
ProteinModelPortal	P20338	http://www.proteinmodelportal.org/query/uniprot/P20338
PubMed	10698684	http://www.ncbi.nlm.nih.gov/pubmed/10698684
PubMed	11786538	http://www.ncbi.nlm.nih.gov/pubmed/11786538
PubMed	11788822	http://www.ncbi.nlm.nih.gov/pubmed/11788822
PubMed	1425574	http://www.ncbi.nlm.nih.gov/pubmed/1425574
PubMed	14617813	http://www.ncbi.nlm.nih.gov/pubmed/14617813
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15280022	http://www.ncbi.nlm.nih.gov/pubmed/15280022
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15907487	http://www.ncbi.nlm.nih.gov/pubmed/15907487
PubMed	16034420	http://www.ncbi.nlm.nih.gov/pubmed/16034420
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	16935861	http://www.ncbi.nlm.nih.gov/pubmed/16935861
PubMed	17786215	http://www.ncbi.nlm.nih.gov/pubmed/17786215
PubMed	1902553	http://www.ncbi.nlm.nih.gov/pubmed/1902553
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	2501306	http://www.ncbi.nlm.nih.gov/pubmed/2501306
Reactome	R-HSA-1445148	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1445148
Reactome	R-HSA-1660499	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1660499
Reactome	R-HSA-8875656	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8875656
RefSeq	NP_001258927	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001258927
RefSeq	NP_004569	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004569
SMR	P20338	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P20338
STRING	9606.ENSP00000355651	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000355651&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TIGRFAMs	TIGR00231	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00231
UCSC	uc001hth	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001hth&org=rat
UniGene	Hs.296169	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.296169
UniProtKB	RAB4A_HUMAN	http://www.uniprot.org/uniprot/RAB4A_HUMAN
UniProtKB-AC	P20338	http://www.uniprot.org/uniprot/P20338
charge	swissprot:RAB4A_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:RAB4A_HUMAN
eggNOG	ENOG410XQ9X	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ9X
eggNOG	KOG0086	http://eggnogapi.embl.de/nog_data/html/tree/KOG0086
epestfind	swissprot:RAB4A_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:RAB4A_HUMAN
garnier	swissprot:RAB4A_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:RAB4A_HUMAN
helixturnhelix	swissprot:RAB4A_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:RAB4A_HUMAN
hmoment	swissprot:RAB4A_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:RAB4A_HUMAN
iep	swissprot:RAB4A_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:RAB4A_HUMAN
inforesidue	swissprot:RAB4A_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:RAB4A_HUMAN
neXtProt	NX_P20338	http://www.nextprot.org/db/entry/NX_P20338
octanol	swissprot:RAB4A_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:RAB4A_HUMAN
pepcoil	swissprot:RAB4A_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:RAB4A_HUMAN
pepdigest	swissprot:RAB4A_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:RAB4A_HUMAN
pepinfo	swissprot:RAB4A_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:RAB4A_HUMAN
pepnet	swissprot:RAB4A_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:RAB4A_HUMAN
pepstats	swissprot:RAB4A_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:RAB4A_HUMAN
pepwheel	swissprot:RAB4A_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:RAB4A_HUMAN
pepwindow	swissprot:RAB4A_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:RAB4A_HUMAN
sigcleave	swissprot:RAB4A_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:RAB4A_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S35A1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P78382-1; Sequence=Displayed; Name=2; IsoId=P78382-2; Sequence=VSP_042916; Note=No experimental confirmation available.; 
# AltName	S35A1_HUMAN	Solute carrier family 35 member A1
# BioGrid	115810	4
# CCDS	CCDS5010	-. [P78382-1]
# CCDS	CCDS55043	-. [P78382-2]
# ChiTaRS	SLC35A1	human
# DISEASE	S35A1_HUMAN	Congenital disorder of glycosylation 2F (CDG2F) [MIM 603585]  CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. {ECO 0000269|PubMed 15576474}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000369552	ENSP00000358565; ENSG00000164414. [P78382-1]
# Ensembl	ENST00000369556	ENSP00000358569; ENSG00000164414. [P78382-2]
# ExpressionAtlas	P78382	baseline and differential
# FUNCTION	S35A1_HUMAN	Transports CMP-sialic acid from the cytosol into Golgi vesicles where glycosyltransferases function. 
# GO_component	GO:0000139	Golgi membrane; TAS:Reactome.
# GO_component	GO:0005794	Golgi apparatus; TAS:ProtInc.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_function	GO:0005456	CMP-N-acetylneuraminate transmembrane transporter activity; TAS:Reactome.
# GO_function	S35A1_HUMAN	GO 0005351 sugar proton symporter activity; IEA InterPro.
# GO_process	GO:0005975	carbohydrate metabolic process; TAS:ProtInc.
# GO_process	GO:0006464	cellular protein modification process; TAS:ProtInc.
# GO_process	GO:0015782	CMP-N-acetylneuraminate transport; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0005975	carbohydrate metabolic process
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0006810	transport
# Genevisible	P78382	HS
# HGNC	HGNC:11021	SLC35A1
# InterPro	IPR007271	Nuc_sug_transpt
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H00119	[Inherited metabolic disease] Congenital disorders of glycosylation (CDG) type II
# MIM	603585	phenotype
# MIM	605634	gene
# Organism	S35A1_HUMAN	Homo sapiens (Human)
# Orphanet	238459	SLC35A1-CDG
# PANTHER	PTHR10231	PTHR10231
# PIR	JC5023	JC5023
# PIRSF	PIRSF005799	UDP-gal_transpt
# Pfam	PF04142	Nuc_sug_transp
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-4085001	Sialic acid metabolism
# Reactome	R-HSA-727802	Transport of nucleotide sugars
# RecName	S35A1_HUMAN	CMP-sialic acid transporter
# RefSeq	NP_001161870	NM_001168398.1. [P78382-2]
# RefSeq	NP_006407	NM_006416.4. [P78382-1]
# SIMILARITY	Belongs to the nucleotide-sugar transporter family. SLC35A subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	S35A1_HUMAN	Golgi apparatus membrane; Multi-pass membrane protein. 
# TCDB	2.A.7.12.11	the drug/metabolite transporter (dmt) superfamily
# UCSC	uc010kbx	human. [P78382-1]
# eggNOG	COG0697	LUCA
# eggNOG	KOG2234	Eukaryota
BLAST	swissprot:S35A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S35A1_HUMAN
COXPRESdb	10559	http://coxpresdb.jp/data/gene/10559.shtml
CleanEx	HS_SLC35A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC35A1
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1093/oxfordjournals.jbchem.a021523	http://dx.doi.org/10.1093/oxfordjournals.jbchem.a021523
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1182/blood-2004-09-3509	http://dx.doi.org/10.1182/blood-2004-09-3509
EMBL	AJ851888	http://www.ebi.ac.uk/ena/data/view/AJ851888
EMBL	AL049697	http://www.ebi.ac.uk/ena/data/view/AL049697
EMBL	BC017807	http://www.ebi.ac.uk/ena/data/view/BC017807
EMBL	D87969	http://www.ebi.ac.uk/ena/data/view/D87969
Ensembl	ENST00000369552	http://www.ensembl.org/id/ENST00000369552
Ensembl	ENST00000369556	http://www.ensembl.org/id/ENST00000369556
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005351	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005351
GO_function	GO:0005456	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005456
GO_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GO_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GO_process	GO:0015782	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015782
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC35A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC35A1
GeneID	10559	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10559
GeneTree	ENSGT00550000074563	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074563
HGNC	HGNC:11021	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11021
HOGENOM	HOG000216649	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000216649&db=HOGENOM6
HOVERGEN	HBG054025	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054025&db=HOVERGEN
InParanoid	P78382	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P78382
InterPro	IPR007271	http://www.ebi.ac.uk/interpro/entry/IPR007271
Jabion	10559	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10559
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00119	http://www.genome.jp/dbget-bin/www_bget?H00119
KEGG_Gene	hsa:10559	http://www.genome.jp/dbget-bin/www_bget?hsa:10559
KEGG_Orthology	KO:K15272	http://www.genome.jp/dbget-bin/www_bget?KO:K15272
MIM	603585	http://www.ncbi.nlm.nih.gov/omim/603585
MIM	605634	http://www.ncbi.nlm.nih.gov/omim/605634
OMA	RNIQLYL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RNIQLYL
Orphanet	238459	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=238459
OrthoDB	EOG091G0CHS	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0CHS
PANTHER	PTHR10231	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10231
PSORT	swissprot:S35A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S35A1_HUMAN
PSORT-B	swissprot:S35A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S35A1_HUMAN
PSORT2	swissprot:S35A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S35A1_HUMAN
Pfam	PF04142	http://pfam.xfam.org/family/PF04142
PharmGKB	PA35889	http://www.pharmgkb.org/do/serve?objId=PA35889&objCls=Gene
Phobius	swissprot:S35A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S35A1_HUMAN
PhylomeDB	P78382	http://phylomedb.org/?seqid=P78382
ProteinModelPortal	P78382	http://www.proteinmodelportal.org/query/uniprot/P78382
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15576474	http://www.ncbi.nlm.nih.gov/pubmed/15576474
PubMed	9010752	http://www.ncbi.nlm.nih.gov/pubmed/9010752
Reactome	R-HSA-4085001	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-4085001
Reactome	R-HSA-727802	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-727802
RefSeq	NP_001161870	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001161870
RefSeq	NP_006407	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006407
STRING	9606.ENSP00000358565	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000358565&targetmode=cogs
TCDB	2.A.7.12.11	http://www.tcdb.org/search/result.php?tc=2.A.7.12.11
UCSC	uc010kbx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010kbx&org=rat
UniGene	Hs.423163	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.423163
UniProtKB	S35A1_HUMAN	http://www.uniprot.org/uniprot/S35A1_HUMAN
UniProtKB-AC	P78382	http://www.uniprot.org/uniprot/P78382
charge	swissprot:S35A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S35A1_HUMAN
eggNOG	COG0697	http://eggnogapi.embl.de/nog_data/html/tree/COG0697
eggNOG	KOG2234	http://eggnogapi.embl.de/nog_data/html/tree/KOG2234
epestfind	swissprot:S35A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S35A1_HUMAN
garnier	swissprot:S35A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S35A1_HUMAN
helixturnhelix	swissprot:S35A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S35A1_HUMAN
hmoment	swissprot:S35A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S35A1_HUMAN
iep	swissprot:S35A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S35A1_HUMAN
inforesidue	swissprot:S35A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S35A1_HUMAN
neXtProt	NX_P78382	http://www.nextprot.org/db/entry/NX_P78382
octanol	swissprot:S35A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S35A1_HUMAN
pepcoil	swissprot:S35A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S35A1_HUMAN
pepdigest	swissprot:S35A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S35A1_HUMAN
pepinfo	swissprot:S35A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S35A1_HUMAN
pepnet	swissprot:S35A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S35A1_HUMAN
pepstats	swissprot:S35A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S35A1_HUMAN
pepwheel	swissprot:S35A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S35A1_HUMAN
pepwindow	swissprot:S35A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S35A1_HUMAN
sigcleave	swissprot:S35A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S35A1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SERC2_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q96SA4-1; Sequence=Displayed; Name=2; IsoId=Q96SA4-2; Sequence=VSP_042464; Name=3; IsoId=Q96SA4-3; Sequence=VSP_042463; Name=4; IsoId=Q96SA4-4; Sequence=VSP_046840; Note=No experimental confirmation available. Gene prediction based on cDNA data.; 
# AltName	SERC2_HUMAN	Tumor differentially expressed protein 2-like
# BioGrid	131485	8
# CCDS	CCDS30662	-. [Q96SA4-1]
# CCDS	CCDS55583	-. [Q96SA4-4]
# CCDS	CCDS55584	-. [Q96SA4-3]
# CCDS	CCDS55585	-. [Q96SA4-2]
# ChiTaRS	SERINC2	human
# Ensembl	ENST00000373709	ENSP00000362813; ENSG00000168528. [Q96SA4-1]
# Ensembl	ENST00000373710	ENSP00000362814; ENSG00000168528. [Q96SA4-4]
# Ensembl	ENST00000536384	ENSP00000439048; ENSG00000168528. [Q96SA4-2]
# Ensembl	ENST00000536859	ENSP00000444307; ENSG00000168528. [Q96SA4-3]
# GO_component	GO:0016021	integral component of membrane; IBA:GO_Central.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0015194	L-serine transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0006658	phosphatidylserine metabolic process; IEA:Ensembl.
# GO_process	GO:0006665	sphingolipid metabolic process; IEA:InterPro.
# GO_process	GO:1904219	positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity; IEA:Ensembl.
# GO_process	GO:1904222	positive regulation of serine C-palmitoyltransferase activity; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q96SA4	HS
# HGNC	HGNC:23231	SERINC2
# InterPro	IPR005016	TDE1/TMS
# InterPro	IPR029554	SERINC2
# MIM	614549	gene
# Organism	SERC2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10383	PTHR10383
# PANTHER	PTHR10383:SF22	PTHR10383:SF22
# Pfam	PF03348	Serinc
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-977347	Serine biosynthesis
# RecName	SERC2_HUMAN	Serine incorporator 2
# RefSeq	NP_001185966	NM_001199037.1. [Q96SA4-3]
# RefSeq	NP_001185967	NM_001199038.1. [Q96SA4-4]
# RefSeq	NP_001185968	NM_001199039.1
# RefSeq	NP_061035	NM_018565.3. [Q96SA4-2]
# RefSeq	NP_849196	NM_178865.4. [Q96SA4-1]
# SIMILARITY	Belongs to the TDE1 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	SERC2_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# UCSC	uc001bst	human. [Q96SA4-1]
# eggNOG	ENOG410XP7K	LUCA
# eggNOG	KOG2592	Eukaryota
BLAST	swissprot:SERC2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SERC2_HUMAN
BioCyc	ZFISH:ENSG00000168528-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000168528-MONOMER
COXPRESdb	347735	http://coxpresdb.jp/data/gene/347735.shtml
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC114494	http://www.ebi.ac.uk/ena/data/view/AC114494
EMBL	AF352325	http://www.ebi.ac.uk/ena/data/view/AF352325
EMBL	AK296118	http://www.ebi.ac.uk/ena/data/view/AK296118
EMBL	AK298512	http://www.ebi.ac.uk/ena/data/view/AK298512
EMBL	AK316357	http://www.ebi.ac.uk/ena/data/view/AK316357
EMBL	AY094595	http://www.ebi.ac.uk/ena/data/view/AY094595
EMBL	AY358560	http://www.ebi.ac.uk/ena/data/view/AY358560
EMBL	BC084580	http://www.ebi.ac.uk/ena/data/view/BC084580
EMBL	BC126283	http://www.ebi.ac.uk/ena/data/view/BC126283
EMBL	BC126285	http://www.ebi.ac.uk/ena/data/view/BC126285
Ensembl	ENST00000373709	http://www.ensembl.org/id/ENST00000373709
Ensembl	ENST00000373710	http://www.ensembl.org/id/ENST00000373710
Ensembl	ENST00000536384	http://www.ensembl.org/id/ENST00000536384
Ensembl	ENST00000536859	http://www.ensembl.org/id/ENST00000536859
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0015194	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015194
GO_process	GO:0006658	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006658
GO_process	GO:0006665	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006665
GO_process	GO:1904219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1904219
GO_process	GO:1904222	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1904222
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	SERINC2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SERINC2
GeneID	347735	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=347735
GeneTree	ENSGT00550000074522	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074522
H-InvDB	HIX0000354	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0000354
HGNC	HGNC:23231	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:23231
HOGENOM	HOG000165463	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000165463&db=HOGENOM6
HOVERGEN	HBG025699	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG025699&db=HOVERGEN
HPA	HPA005974	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA005974
InParanoid	Q96SA4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96SA4
InterPro	IPR005016	http://www.ebi.ac.uk/interpro/entry/IPR005016
InterPro	IPR029554	http://www.ebi.ac.uk/interpro/entry/IPR029554
Jabion	347735	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=347735
KEGG_Gene	hsa:347735	http://www.genome.jp/dbget-bin/www_bget?hsa:347735
MIM	614549	http://www.ncbi.nlm.nih.gov/omim/614549
OMA	PEQKCNP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PEQKCNP
OrthoDB	EOG091G07WS	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07WS
PANTHER	PTHR10383	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10383
PANTHER	PTHR10383:SF22	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10383:SF22
PSORT	swissprot:SERC2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SERC2_HUMAN
PSORT-B	swissprot:SERC2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SERC2_HUMAN
PSORT2	swissprot:SERC2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SERC2_HUMAN
Pfam	PF03348	http://pfam.xfam.org/family/PF03348
PharmGKB	PA134933002	http://www.pharmgkb.org/do/serve?objId=PA134933002&objCls=Gene
Phobius	swissprot:SERC2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SERC2_HUMAN
ProteinModelPortal	Q96SA4	http://www.proteinmodelportal.org/query/uniprot/Q96SA4
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
Reactome	R-HSA-977347	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-977347
RefSeq	NP_001185966	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001185966
RefSeq	NP_001185967	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001185967
RefSeq	NP_001185968	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001185968
RefSeq	NP_061035	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061035
RefSeq	NP_849196	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_849196
STRING	9606.ENSP00000362814	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000362814&targetmode=cogs
UCSC	uc001bst	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001bst&org=rat
UniGene	Hs.270655	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.270655
UniProtKB	SERC2_HUMAN	http://www.uniprot.org/uniprot/SERC2_HUMAN
UniProtKB-AC	Q96SA4	http://www.uniprot.org/uniprot/Q96SA4
charge	swissprot:SERC2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SERC2_HUMAN
eggNOG	ENOG410XP7K	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XP7K
eggNOG	KOG2592	http://eggnogapi.embl.de/nog_data/html/tree/KOG2592
epestfind	swissprot:SERC2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SERC2_HUMAN
garnier	swissprot:SERC2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SERC2_HUMAN
helixturnhelix	swissprot:SERC2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SERC2_HUMAN
hmoment	swissprot:SERC2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SERC2_HUMAN
iep	swissprot:SERC2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SERC2_HUMAN
inforesidue	swissprot:SERC2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SERC2_HUMAN
neXtProt	NX_Q96SA4	http://www.nextprot.org/db/entry/NX_Q96SA4
octanol	swissprot:SERC2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SERC2_HUMAN
pepcoil	swissprot:SERC2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SERC2_HUMAN
pepdigest	swissprot:SERC2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SERC2_HUMAN
pepinfo	swissprot:SERC2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SERC2_HUMAN
pepnet	swissprot:SERC2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SERC2_HUMAN
pepstats	swissprot:SERC2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SERC2_HUMAN
pepwheel	swissprot:SERC2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SERC2_HUMAN
pepwindow	swissprot:SERC2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SERC2_HUMAN
sigcleave	swissprot:SERC2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SERC2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SERC3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13530-1; Sequence=Displayed; Name=2; IsoId=Q13530-2; Sequence=VSP_056833; Note=No experimental confirmation available.; 
# AltName	Tumor differentially expressed protein 1 {ECO:0000303|PubMed	10559794}
# BioGrid	116155	12
# CCDS	CCDS13333	-. [Q13530-1]
# ChiTaRS	SERINC3	human
# Ensembl	ENST00000255175	ENSP00000255175; ENSG00000132824. [Q13530-1]
# Ensembl	ENST00000342374	ENSP00000340243; ENSG00000132824. [Q13530-1]
# ExpressionAtlas	Q13530	baseline and differential
# FUNCTION	SERC3_HUMAN	Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1  acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed 26416733, PubMed 26416734). {ECO 0000269|PubMed 26416733, ECO 0000269|PubMed 26416734}. 
# GO_component	GO:0000139	Golgi membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
# GO_function	GO:0015194	L-serine transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0006658	phosphatidylserine metabolic process; IEA:InterPro.
# GO_process	GO:0006665	sphingolipid metabolic process; IEA:InterPro.
# GO_process	GO:0009597	detection of virus; IDA:UniProtKB.
# GO_process	GO:0045087	innate immune response; IDA:UniProtKB.
# GO_process	GO:0051607	defense response to virus; IDA:UniProtKB.
# GO_process	GO:1902237	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# Genevisible	Q13530	HS
# HGNC	HGNC:11699	SERINC3
# IntAct	Q13530	3
# InterPro	IPR005016	TDE1/TMS
# InterPro	IPR029557	Serinc3
# MIM	607165	gene
# Organism	SERC3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10383	PTHR10383
# PANTHER	PTHR10383:SF27	PTHR10383:SF27
# PTM	SERC3_HUMAN	N-glycosylated. {ECO 0000250|UniProtKB Q9QZI9}. 
# Pfam	PF03348	Serinc
# Proteomes	UP000005640	Chromosome 20
# Reactome	R-HSA-977347	Serine biosynthesis
# RecName	SERC3_HUMAN	Serine incorporator 3
# RefSeq	NP_006802	NM_006811.3. [Q13530-1]
# RefSeq	NP_945179	NM_198941.2. [Q13530-1]
# RefSeq	XP_016883090	XM_017027601.1. [Q13530-2]
# SEQUENCE CAUTION	Sequence=AAB48858.1; Type=Frameshift; Positions=321, 393, 407, 459; Evidence={ECO:0000305}; Sequence=AAD34641.1; Type=Frameshift; Positions=321, 393, 407, 459; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the TDE1 family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	SERC3_HUMAN	Cell membrane {ECO 0000250|UniProtKB Q86VE9}; Multi-pass membrane protein {ECO 0000255}. Golgi apparatus membrane {ECO 0000250|UniProtKB Q9QZI9}; Multi-pass membrane protein {ECO 0000250|UniProtKB Q9QZI9}. 
# SUBCELLULAR LOCATION	SERC3_HUMAN	Cytoplasm, perinuclear region {ECO 0000305|PubMed 26416734}. Note=(Microbial infection) Upon HIV-1 infection, it is redirected to perinuclear region following interaction with HIV-1 Nef, excluding it from virions particles, thereby preventing subsequent antiviral defense activity (Probable). {ECO 0000305|PubMed 26416734}. 
# TCDB	9.A.29.3	the lantibiotic immunity protein/serine connector (lip/sip) family
# TISSUE SPECIFICITY	Ubiquitous. Expression levels were increased fourfold to tenfold in lung tumor tissues compared with normal pulmonary tissues. {ECO:0000269|PubMed	10559794}. 
# UCSC	uc002xme	human. [Q13530-1]
# eggNOG	ENOG410XP7K	LUCA
# eggNOG	KOG2592	Eukaryota
BLAST	swissprot:SERC3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SERC3_HUMAN
BioCyc	ZFISH:ENSG00000132824-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000132824-MONOMER
COXPRESdb	10955	http://coxpresdb.jp/data/gene/10955.shtml
CleanEx	HS_SERINC3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SERINC3
DOI	10.1002/(SICI)1098-2744(199911)26:3<189::AID-MC8>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-2744(199911)26:3<189::AID-MC8>3.0.CO
DOI	10.1038/414865a	http://dx.doi.org/10.1038/414865a
DOI	10.1038/nature15399	http://dx.doi.org/10.1038/nature15399
DOI	10.1038/nature15400	http://dx.doi.org/10.1038/nature15400
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF112227	http://www.ebi.ac.uk/ena/data/view/AF112227
EMBL	AF153979	http://www.ebi.ac.uk/ena/data/view/AF153979
EMBL	AK300618	http://www.ebi.ac.uk/ena/data/view/AK300618
EMBL	BC006088	http://www.ebi.ac.uk/ena/data/view/BC006088
EMBL	U49188	http://www.ebi.ac.uk/ena/data/view/U49188
EMBL	Z97053	http://www.ebi.ac.uk/ena/data/view/Z97053
Ensembl	ENST00000255175	http://www.ensembl.org/id/ENST00000255175
Ensembl	ENST00000342374	http://www.ensembl.org/id/ENST00000342374
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_function	GO:0015194	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015194
GO_process	GO:0006658	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006658
GO_process	GO:0006665	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006665
GO_process	GO:0009597	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009597
GO_process	GO:0045087	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045087
GO_process	GO:0051607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051607
GO_process	GO:1902237	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902237
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
GeneCards	SERINC3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SERINC3
GeneID	10955	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10955
GeneTree	ENSGT00550000074522	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074522
HGNC	HGNC:11699	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11699
HOGENOM	HOG000165463	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000165463&db=HOGENOM6
HOVERGEN	HBG025699	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG025699&db=HOVERGEN
HPA	HPA043993	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA043993
HPA	HPA048116	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA048116
InParanoid	Q13530	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q13530
IntAct	Q13530	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q13530*
InterPro	IPR005016	http://www.ebi.ac.uk/interpro/entry/IPR005016
InterPro	IPR029557	http://www.ebi.ac.uk/interpro/entry/IPR029557
Jabion	10955	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10955
KEGG_Gene	hsa:10955	http://www.genome.jp/dbget-bin/www_bget?hsa:10955
MIM	607165	http://www.ncbi.nlm.nih.gov/omim/607165
OMA	EPERNCN	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EPERNCN
OrthoDB	EOG091G07WS	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07WS
PANTHER	PTHR10383	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10383
PANTHER	PTHR10383:SF27	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10383:SF27
PSORT	swissprot:SERC3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SERC3_HUMAN
PSORT-B	swissprot:SERC3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SERC3_HUMAN
PSORT2	swissprot:SERC3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SERC3_HUMAN
Pfam	PF03348	http://pfam.xfam.org/family/PF03348
PharmGKB	PA36418	http://www.pharmgkb.org/do/serve?objId=PA36418&objCls=Gene
Phobius	swissprot:SERC3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SERC3_HUMAN
PhylomeDB	Q13530	http://phylomedb.org/?seqid=Q13530
ProteinModelPortal	Q13530	http://www.proteinmodelportal.org/query/uniprot/Q13530
PubMed	10559794	http://www.ncbi.nlm.nih.gov/pubmed/10559794
PubMed	11780052	http://www.ncbi.nlm.nih.gov/pubmed/11780052
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	26416733	http://www.ncbi.nlm.nih.gov/pubmed/26416733
PubMed	26416734	http://www.ncbi.nlm.nih.gov/pubmed/26416734
Reactome	R-HSA-977347	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-977347
RefSeq	NP_006802	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006802
RefSeq	NP_945179	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_945179
RefSeq	XP_016883090	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016883090
STRING	9606.ENSP00000255175	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000255175&targetmode=cogs
TCDB	9.A.29.3	http://www.tcdb.org/search/result.php?tc=9.A.29.3
UCSC	uc002xme	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002xme&org=rat
UniGene	Hs.272168	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.272168
UniGene	Hs.696712	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.696712
UniGene	Hs.744982	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.744982
UniProtKB	SERC3_HUMAN	http://www.uniprot.org/uniprot/SERC3_HUMAN
UniProtKB-AC	Q13530	http://www.uniprot.org/uniprot/Q13530
charge	swissprot:SERC3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SERC3_HUMAN
eggNOG	ENOG410XP7K	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XP7K
eggNOG	KOG2592	http://eggnogapi.embl.de/nog_data/html/tree/KOG2592
epestfind	swissprot:SERC3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SERC3_HUMAN
garnier	swissprot:SERC3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SERC3_HUMAN
helixturnhelix	swissprot:SERC3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SERC3_HUMAN
hmoment	swissprot:SERC3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SERC3_HUMAN
iep	swissprot:SERC3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SERC3_HUMAN
inforesidue	swissprot:SERC3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SERC3_HUMAN
neXtProt	NX_Q13530	http://www.nextprot.org/db/entry/NX_Q13530
octanol	swissprot:SERC3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SERC3_HUMAN
pepcoil	swissprot:SERC3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SERC3_HUMAN
pepdigest	swissprot:SERC3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SERC3_HUMAN
pepinfo	swissprot:SERC3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SERC3_HUMAN
pepnet	swissprot:SERC3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SERC3_HUMAN
pepstats	swissprot:SERC3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SERC3_HUMAN
pepwheel	swissprot:SERC3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SERC3_HUMAN
pepwindow	swissprot:SERC3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SERC3_HUMAN
sigcleave	swissprot:SERC3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SERC3_HUMAN
## Database	ID	URL or Descriptions
# AltName	S20A1_HUMAN	Gibbon ape leukemia virus receptor 1
# AltName	S20A1_HUMAN	Leukemia virus receptor 1 homolog
# AltName	S20A1_HUMAN	Phosphate transporter 1
# AltName	S20A1_HUMAN	Solute carrier family 20 member 1
# BIOPHYSICOCHEMICAL PROPERTIES	S20A1_HUMAN	Kinetic parameters  KM=24.1 uM for phosphate {ECO 0000269|PubMed 7929240, ECO 0000269|PubMed 8041748}; Vmax=1.9 nmol/min/mg enzyme (in the presence of 0.05-2 mM phosphate) {ECO 0000269|PubMed 7929240, ECO 0000269|PubMed 8041748}; Note=With an increase in pH, a decrease in phosphate uptake is observed.; pH dependence  Optimum pH is 6.5 and 7.5. {ECO 0000269|PubMed 7929240, ECO 0000269|PubMed 8041748}; 
# BRENDA	3.6.3.27	2681
# BioGrid	112462	25
# ChiTaRS	SLC20A1	human
# DOMAIN	S20A1_HUMAN	Region A confers human cells susceptibility to infection by Gibbon Ape Leukemia Virus (GaLV) and Feline leukemia virus subgroup B (FeLV-B). Substitution of Human SLC20A1 region A by region A of murine SLC20A1 prevents viral infection. 
# Ensembl	ENST00000272542	ENSP00000272542; ENSG00000144136
# ExpressionAtlas	Q8WUM9	baseline and differential
# FUNCTION	S20A1_HUMAN	Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV). {ECO 0000269|PubMed 11009570, ECO 0000269|PubMed 12097582, ECO 0000269|PubMed 1309898, ECO 0000269|PubMed 1531369, ECO 0000269|PubMed 2078500, ECO 0000269|PubMed 7929240, ECO 0000269|PubMed 7966619, ECO 0000269|PubMed 8041748}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_function	GO:0004871	signal transducer activity; IMP:UniProtKB.
# GO_function	GO:0004872	receptor activity; TAS:ProtInc.
# GO_function	GO:0005315	inorganic phosphate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015321	sodium-dependent phosphate transmembrane transporter activity; TAS:Reactome.
# GO_function	S20A1_HUMAN	GO 0005316 high-affinity inorganic phosphate sodium symporter activity; IEA Ensembl.
# GO_function	S20A1_HUMAN	GO 0005436 sodium phosphate symporter activity; TAS ProtInc.
# GO_function	S20A1_HUMAN	GO 0015319 sodium inorganic phosphate symporter activity; IBA GO_Central.
# GO_process	GO:0006796	phosphate-containing compound metabolic process; TAS:ProtInc.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q8WUM9	HS
# HGNC	HGNC:10946	SLC20A1
# INDUCTION	S20A1_HUMAN	By phosphate deprivation as well as by IL8/interleukin- 8 in hypertrophic chondrocytes. {ECO 0000269|PubMed 15641067, ECO 0000269|PubMed 8041748}. 
# IntAct	Q8WUM9	6
# InterPro	IPR001204	Phos_transporter
# KEGG_Brite	ko02001	Solute carrier family
# MIM	137570	gene
# Organism	S20A1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11101	PTHR11101; 2
# PIR	I52822	I52822
# Pfam	PF01384	PHO4
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-427652	Sodium-coupled phosphate cotransporters
# RecName	S20A1_HUMAN	Sodium-dependent phosphate transporter 1
# RefSeq	NP_005406	NM_005415.4
# SIMILARITY	Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S20A1_HUMAN	Membrane; Multi-pass membrane protein. 
# TCDB	2.A.20.2	the inorganic phosphate transporter (pit) family
# TISSUE SPECIFICITY	Ubiquitously expressed. {ECO:0000269|PubMed	2078500}. 
# UCSC	uc002tib	human
# eggNOG	COG0306	LUCA
# eggNOG	KOG2493	Eukaryota
BLAST	swissprot:S20A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S20A1_HUMAN
BioCyc	ZFISH:ENSG00000144136-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000144136-MONOMER
COXPRESdb	6574	http://coxpresdb.jp/data/gene/6574.shtml
CleanEx	HS_SLC20A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC20A1
DOI	10.1002/art.20748	http://dx.doi.org/10.1002/art.20748
DOI	10.1016/S0378-1119(98)00572-1	http://dx.doi.org/10.1016/S0378-1119(98)00572-1
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.91.15.7071	http://dx.doi.org/10.1073/pnas.91.15.7071
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1128/JVI.76.15.7683-7693.2002	http://dx.doi.org/10.1128/JVI.76.15.7683-7693.2002
DOI	10.1161/01.RES.87.7.e10	http://dx.doi.org/10.1161/01.RES.87.7.e10
EMBL	AC079922	http://www.ebi.ac.uk/ena/data/view/AC079922
EMBL	AH007490	http://www.ebi.ac.uk/ena/data/view/AH007490
EMBL	BC019944	http://www.ebi.ac.uk/ena/data/view/BC019944
EMBL	BC075818	http://www.ebi.ac.uk/ena/data/view/BC075818
EMBL	L20859	http://www.ebi.ac.uk/ena/data/view/L20859
Ensembl	ENST00000272542	http://www.ensembl.org/id/ENST00000272542
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GO_function	GO:0004872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004872
GO_function	GO:0005315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005315
GO_function	GO:0005316	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005316
GO_function	GO:0005436	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005436
GO_function	GO:0015319	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015319
GO_function	GO:0015321	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015321
GO_process	GO:0006796	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006796
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0043123	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043123
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	SLC20A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC20A1
GeneID	6574	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6574
GeneTree	ENSGT00390000014879	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000014879
HGNC	HGNC:10946	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10946
HOGENOM	HOG000231892	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231892&db=HOGENOM6
HOVERGEN	HBG053358	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053358&db=HOVERGEN
HPA	CAB019279	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB019279
HPA	HPA035834	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035834
InParanoid	Q8WUM9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8WUM9
IntAct	Q8WUM9	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8WUM9*
InterPro	IPR001204	http://www.ebi.ac.uk/interpro/entry/IPR001204
Jabion	6574	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6574
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6574	http://www.genome.jp/dbget-bin/www_bget?hsa:6574
KEGG_Orthology	KO:K14640	http://www.genome.jp/dbget-bin/www_bget?KO:K14640
MIM	137570	http://www.ncbi.nlm.nih.gov/omim/137570
OMA	WINLATW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WINLATW
OrthoDB	EOG091G07J5	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07J5
PANTHER	PTHR11101	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11101
PSORT	swissprot:S20A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S20A1_HUMAN
PSORT-B	swissprot:S20A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S20A1_HUMAN
PSORT2	swissprot:S20A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S20A1_HUMAN
Pfam	PF01384	http://pfam.xfam.org/family/PF01384
PharmGKB	PA35833	http://www.pharmgkb.org/do/serve?objId=PA35833&objCls=Gene
Phobius	swissprot:S20A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S20A1_HUMAN
PhylomeDB	Q8WUM9	http://phylomedb.org/?seqid=Q8WUM9
ProteinModelPortal	Q8WUM9	http://www.proteinmodelportal.org/query/uniprot/Q8WUM9
PubMed	11009570	http://www.ncbi.nlm.nih.gov/pubmed/11009570
PubMed	12097582	http://www.ncbi.nlm.nih.gov/pubmed/12097582
PubMed	1309898	http://www.ncbi.nlm.nih.gov/pubmed/1309898
PubMed	1531369	http://www.ncbi.nlm.nih.gov/pubmed/1531369
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15641067	http://www.ncbi.nlm.nih.gov/pubmed/15641067
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	2078500	http://www.ncbi.nlm.nih.gov/pubmed/2078500
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	7929240	http://www.ncbi.nlm.nih.gov/pubmed/7929240
PubMed	7966619	http://www.ncbi.nlm.nih.gov/pubmed/7966619
PubMed	8041748	http://www.ncbi.nlm.nih.gov/pubmed/8041748
PubMed	8411375	http://www.ncbi.nlm.nih.gov/pubmed/8411375
PubMed	9889306	http://www.ncbi.nlm.nih.gov/pubmed/9889306
Reactome	R-HSA-427652	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-427652
RefSeq	NP_005406	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005406
STRING	9606.ENSP00000272542	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000272542&targetmode=cogs
TCDB	2.A.20.2	http://www.tcdb.org/search/result.php?tc=2.A.20.2
UCSC	uc002tib	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002tib&org=rat
UniGene	Hs.187946	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.187946
UniGene	Hs.732750	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.732750
UniProtKB	S20A1_HUMAN	http://www.uniprot.org/uniprot/S20A1_HUMAN
UniProtKB-AC	Q8WUM9	http://www.uniprot.org/uniprot/Q8WUM9
charge	swissprot:S20A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S20A1_HUMAN
eggNOG	COG0306	http://eggnogapi.embl.de/nog_data/html/tree/COG0306
eggNOG	KOG2493	http://eggnogapi.embl.de/nog_data/html/tree/KOG2493
epestfind	swissprot:S20A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S20A1_HUMAN
garnier	swissprot:S20A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S20A1_HUMAN
helixturnhelix	swissprot:S20A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S20A1_HUMAN
hmoment	swissprot:S20A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S20A1_HUMAN
iep	swissprot:S20A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S20A1_HUMAN
inforesidue	swissprot:S20A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S20A1_HUMAN
neXtProt	NX_Q8WUM9	http://www.nextprot.org/db/entry/NX_Q8WUM9
octanol	swissprot:S20A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S20A1_HUMAN
pepcoil	swissprot:S20A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S20A1_HUMAN
pepdigest	swissprot:S20A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S20A1_HUMAN
pepinfo	swissprot:S20A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S20A1_HUMAN
pepnet	swissprot:S20A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S20A1_HUMAN
pepstats	swissprot:S20A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S20A1_HUMAN
pepwheel	swissprot:S20A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S20A1_HUMAN
pepwindow	swissprot:S20A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S20A1_HUMAN
sigcleave	swissprot:S20A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S20A1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNG4_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8TDN1-1; Sequence=Displayed; Name=2; IsoId=Q8TDN1-2; Sequence=VSP_001029, VSP_001030; Note=No experimental confirmation available.; 
# AltName	KCNG4_HUMAN	Voltage-gated potassium channel subunit Kv6.4
# BioGrid	125002	5
# CCDS	CCDS10945	-. [Q8TDN1-1]
# DOMAIN	KCNG4_HUMAN	The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. {ECO 0000250|UniProtKB P63142}. 
# Ensembl	ENST00000308251	ENSP00000312129; ENSG00000168418. [Q8TDN1-1]
# Ensembl	ENST00000568181	ENSP00000457897; ENSG00000168418. [Q8TDN1-2]
# ExpressionAtlas	Q8TDN1	baseline and differential
# FUNCTION	KCNG4_HUMAN	Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed 19074135). {ECO 0000269|PubMed 19074135}. 
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IEA:InterPro.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; IDA:UniProtKB.
# GO_function	GO:0044325	ion channel binding; IPI:UniProtKB.
# GO_process	GO:0051260	protein homooligomerization; IEA:InterPro.
# GO_process	GO:0071805	potassium ion transmembrane transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.350	-; 1.
# Genevisible	Q8TDN1	HS
# HGNC	HGNC:19697	KCNG4
# InterPro	IPR003131	T1-type_BTB
# InterPro	IPR003968	K_chnl_volt-dep_Kv
# InterPro	IPR003971	K_chnl_volt-dep_Kv9
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR011333	SKP1/BTB/POZ
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko04040	Ion channels
# MIM	607603	gene
# Organism	KCNG4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11537	PTHR11537
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01491	KVCHANNEL
# PRINTS	PR01494	KV9CHANNEL
# Pfam	PF00520	Ion_trans
# Pfam	PF02214	BTB_2
# Proteomes	UP000005640	Chromosome 16
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# RecName	KCNG4_HUMAN	Potassium voltage-gated channel subfamily G member 4
# RefSeq	NP_758857	NM_172347.2. [Q8TDN1-1]
# SIMILARITY	Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.4/KCNG4 sub-subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCNG4_HUMAN	Cell membrane {ECO 0000269|PubMed 19074135}; Multi-pass membrane protein {ECO 0000305}. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Colocalizes with KCNB1 at the plasma membrane. Remains intracellular in the absence of KCNB1 (PubMed 19074135). {ECO 0000269|PubMed 19074135}. 
# SUBUNIT	Heterotetramer with KCNB1 (PubMed:19074135). {ECO	0000269|PubMed:19074135}. 
# SUPFAM	SSF54695	SSF54695
# TISSUE SPECIFICITY	KCNG4_HUMAN	Highly expressed in brain, and at lower levels in liver, small intestine and colon. 
# UCSC	uc002fhu	human. [Q8TDN1-1]
# eggNOG	COG1226	LUCA
# eggNOG	KOG3713	Eukaryota
BLAST	swissprot:KCNG4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNG4_HUMAN
BioCyc	ZFISH:ENSG00000168418-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000168418-MONOMER
COXPRESdb	93107	http://coxpresdb.jp/data/gene/93107.shtml
CleanEx	HS_KCNG3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNG3
CleanEx	HS_KCNG4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNG4
DOI	10.1073/pnas.122617999	http://dx.doi.org/10.1073/pnas.122617999
DOI	10.1074/jbc.M808786200	http://dx.doi.org/10.1074/jbc.M808786200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF348984	http://www.ebi.ac.uk/ena/data/view/AF348984
EMBL	BC008969	http://www.ebi.ac.uk/ena/data/view/BC008969
Ensembl	ENST00000308251	http://www.ensembl.org/id/ENST00000308251
Ensembl	ENST00000568181	http://www.ensembl.org/id/ENST00000568181
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_function	GO:0044325	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044325
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	KCNG4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNG4
GeneID	93107	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=93107
GeneTree	ENSGT00760000118981	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118981
HGNC	HGNC:19697	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:19697
HOGENOM	HOG000231014	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231014&db=HOGENOM6
HOVERGEN	HBG100172	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG100172&db=HOVERGEN
HPA	HPA039161	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA039161
InParanoid	Q8TDN1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8TDN1
InterPro	IPR003131	http://www.ebi.ac.uk/interpro/entry/IPR003131
InterPro	IPR003968	http://www.ebi.ac.uk/interpro/entry/IPR003968
InterPro	IPR003971	http://www.ebi.ac.uk/interpro/entry/IPR003971
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR011333	http://www.ebi.ac.uk/interpro/entry/IPR011333
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	93107	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=93107
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:93107	http://www.genome.jp/dbget-bin/www_bget?hsa:93107
KEGG_Orthology	KO:K04903	http://www.genome.jp/dbget-bin/www_bget?KO:K04903
MIM	607603	http://www.ncbi.nlm.nih.gov/omim/607603
OMA	CCLRKLL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CCLRKLL
OrthoDB	EOG091G05DD	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05DD
PANTHER	PTHR11537	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01491	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01491
PRINTS	PR01494	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01494
PSORT	swissprot:KCNG4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNG4_HUMAN
PSORT-B	swissprot:KCNG4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNG4_HUMAN
PSORT2	swissprot:KCNG4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNG4_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF02214	http://pfam.xfam.org/family/PF02214
PharmGKB	PA134989953	http://www.pharmgkb.org/do/serve?objId=PA134989953&objCls=Gene
Phobius	swissprot:KCNG4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNG4_HUMAN
PhylomeDB	Q8TDN1	http://phylomedb.org/?seqid=Q8TDN1
ProteinModelPortal	Q8TDN1	http://www.proteinmodelportal.org/query/uniprot/Q8TDN1
PubMed	12060745	http://www.ncbi.nlm.nih.gov/pubmed/12060745
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19074135	http://www.ncbi.nlm.nih.gov/pubmed/19074135
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
RefSeq	NP_758857	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_758857
STRING	9606.ENSP00000312129	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000312129&targetmode=cogs
SUPFAM	SSF54695	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54695
UCSC	uc002fhu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002fhu&org=rat
UniGene	Hs.335877	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.335877
UniGene	Hs.560407	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.560407
UniGene	Hs.737415	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.737415
UniProtKB	KCNG4_HUMAN	http://www.uniprot.org/uniprot/KCNG4_HUMAN
UniProtKB-AC	Q8TDN1	http://www.uniprot.org/uniprot/Q8TDN1
charge	swissprot:KCNG4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNG4_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG3713	http://eggnogapi.embl.de/nog_data/html/tree/KOG3713
epestfind	swissprot:KCNG4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNG4_HUMAN
garnier	swissprot:KCNG4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNG4_HUMAN
helixturnhelix	swissprot:KCNG4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNG4_HUMAN
hmoment	swissprot:KCNG4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNG4_HUMAN
iep	swissprot:KCNG4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNG4_HUMAN
inforesidue	swissprot:KCNG4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNG4_HUMAN
neXtProt	NX_Q8TDN1	http://www.nextprot.org/db/entry/NX_Q8TDN1
octanol	swissprot:KCNG4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNG4_HUMAN
pepcoil	swissprot:KCNG4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNG4_HUMAN
pepdigest	swissprot:KCNG4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNG4_HUMAN
pepinfo	swissprot:KCNG4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNG4_HUMAN
pepnet	swissprot:KCNG4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNG4_HUMAN
pepstats	swissprot:KCNG4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNG4_HUMAN
pepwheel	swissprot:KCNG4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNG4_HUMAN
pepwindow	swissprot:KCNG4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNG4_HUMAN
sigcleave	swissprot:KCNG4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNG4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S26A7_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1 {ECO 0000269|PubMed 11829495}; Synonyms=1A {ECO 0000269|PubMed 11829495}, 1B {ECO 0000269|PubMed 11829495}; IsoId=Q8TE54-1; Sequence=Displayed; Name=2 {ECO 0000269|PubMed 11829495, ECO 0000269|PubMed 15489334}; Synonyms=B {ECO 0000269|PubMed 15489334}; IsoId=Q8TE54-2; Sequence=VSP_052689; 
# AltName	S26A7_HUMAN	Solute carrier family 26 member 7
# CCDS	CCDS6254	-. [Q8TE54-1]
# CCDS	CCDS6255	-. [Q8TE54-2]
# ChiTaRS	SLC26A7	human
# Ensembl	ENST00000276609	ENSP00000276609; ENSG00000147606. [Q8TE54-1]
# Ensembl	ENST00000309536	ENSP00000309504; ENSG00000147606. [Q8TE54-2]
# Ensembl	ENST00000523719	ENSP00000428849; ENSG00000147606. [Q8TE54-1]
# Ensembl	ENST00000617233	ENSP00000482549; ENSG00000147606. [Q8TE54-1]
# ExpressionAtlas	Q8TE54	baseline and differential
# FUNCTION	S26A7_HUMAN	Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion. {ECO 0000250|UniProtKB Q8R2Z3, ECO 0000269|PubMed 11834742, ECO 0000269|PubMed 12736153}. 
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005768	endosome; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016323	basolateral plasma membrane; IMP:UniProtKB.
# GO_component	GO:0055038	recycling endosome membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0005254	chloride channel activity; IDA:UniProtKB.
# GO_function	GO:0008271	secondary active sulfate transmembrane transporter activity; IEA:InterPro.
# GO_function	GO:0015106	bicarbonate transmembrane transporter activity; ISS:UniProtKB.
# GO_function	GO:0015116	sulfate transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0019531	oxalate transmembrane transporter activity; IDA:UniProtKB.
# GO_function	S26A7_HUMAN	GO 0015301 anion anion antiporter activity; IBA GO_Central.
# GO_process	GO:0001696	gastric acid secretion; IEA:Ensembl.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006820	anion transport; IDA:UniProtKB.
# GO_process	GO:0006821	chloride transport; IDA:UniProtKB.
# GO_process	GO:0008272	sulfate transport; IDA:UniProtKB.
# GO_process	GO:0015701	bicarbonate transport; ISS:UniProtKB.
# GO_process	GO:0019532	oxalate transport; IDA:UniProtKB.
# GO_process	GO:0042391	regulation of membrane potential; IBA:GO_Central.
# GO_process	GO:0051453	regulation of intracellular pH; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# Gene3D	3.30.750.24	-; 2.
# Genevisible	Q8TE54	HS
# HGNC	HGNC:14467	SLC26A7
# InterPro	IPR001902	SLC26A/SulP_fam
# InterPro	IPR002645	STAS_dom
# InterPro	IPR011547	SLC26A/SulP_dom
# InterPro	IPR030329	SLC26A7
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04971	Gastric acid secretion
# MIM	608479	gene
# MISCELLANEOUS	S26A7_HUMAN	Is active at both alkaline and acidic pH. Activity is inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters). 
# Organism	S26A7_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11814	PTHR11814; 2
# PANTHER	PTHR11814:SF75	PTHR11814:SF75; 2
# PROSITE	PS50801	STAS
# Pfam	PF00916	Sulfate_transp
# Pfam	PF01740	STAS
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-427601	Multifunctional anion exchangers
# RecName	S26A7_HUMAN	Anion exchange transporter
# RefSeq	NP_001269285	NM_001282356.1. [Q8TE54-1]
# RefSeq	NP_001269286	NM_001282357.1
# RefSeq	NP_439897	NM_052832.3. [Q8TE54-1]
# RefSeq	NP_599028	NM_134266.1. [Q8TE54-2]
# SIMILARITY	Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. {ECO	0000255}. 
# SIMILARITY	Contains 1 STAS domain. {ECO:0000255|PROSITE- ProRule	PRU00198}.
# SUBCELLULAR LOCATION	S26A7_HUMAN	Recycling endosome membrane {ECO 0000269|PubMed 16524946}; Multi-pass membrane protein {ECO 0000269|PubMed 16524946}. Note=Expressed in the cytoplasm in recycling endosomes of medullary collecting duct cells and in acid-secreting gastric parietal cells. Targeted to the basolateral membrane in hypertonicity and potassium depletion. {ECO 0000269|PubMed 16524946}. 
# SUPFAM	SSF52091	SSF52091; 2
# TCDB	2.A.53.2	the sulfate permease (sulp) family
# TISSUE SPECIFICITY	S26A7_HUMAN	Expressed in tonsillar high endothelial venule endothelial cells (HEVEC), placenta and in testis, expressed in a subgroup of basal cells in the epididymal ducts. {ECO 0000269|PubMed 11829495, ECO 0000269|PubMed 11834742, ECO 0000269|PubMed 15956810, ECO 0000269|PubMed 17504921}. 
# UCSC	uc003yex	human. [Q8TE54-1]
# eggNOG	COG0659	LUCA
# eggNOG	KOG0236	Eukaryota
BLAST	swissprot:S26A7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S26A7_HUMAN
COXPRESdb	115111	http://coxpresdb.jp/data/gene/115111.shtml
CleanEx	HS_SLC26A7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC26A7
DOI	10.1006/geno.2002.6689	http://dx.doi.org/10.1006/geno.2002.6689
DOI	10.1074/jbc.M111802200	http://dx.doi.org/10.1074/jbc.M111802200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1152/ajpgi.00454.2002	http://dx.doi.org/10.1152/ajpgi.00454.2002
DOI	10.1159/000086345	http://dx.doi.org/10.1159/000086345
DOI	10.1530/rep.1.00964	http://dx.doi.org/10.1530/rep.1.00964
DOI	10.1681/ASN.2005111174	http://dx.doi.org/10.1681/ASN.2005111174
EMBL	AF331521	http://www.ebi.ac.uk/ena/data/view/AF331521
EMBL	AJ413228	http://www.ebi.ac.uk/ena/data/view/AJ413228
EMBL	AJ413229	http://www.ebi.ac.uk/ena/data/view/AJ413229
EMBL	AJ413230	http://www.ebi.ac.uk/ena/data/view/AJ413230
EMBL	BC094730	http://www.ebi.ac.uk/ena/data/view/BC094730
EMBL	BC113866	http://www.ebi.ac.uk/ena/data/view/BC113866
EMBL	BC114474	http://www.ebi.ac.uk/ena/data/view/BC114474
EMBL	CH471060	http://www.ebi.ac.uk/ena/data/view/CH471060
EMBL	CH471060	http://www.ebi.ac.uk/ena/data/view/CH471060
Ensembl	ENST00000276609	http://www.ensembl.org/id/ENST00000276609
Ensembl	ENST00000309536	http://www.ensembl.org/id/ENST00000309536
Ensembl	ENST00000523719	http://www.ensembl.org/id/ENST00000523719
Ensembl	ENST00000617233	http://www.ensembl.org/id/ENST00000617233
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0055038	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055038
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0008271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008271
GO_function	GO:0015106	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015106
GO_function	GO:0015116	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015116
GO_function	GO:0015301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015301
GO_function	GO:0019531	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019531
GO_process	GO:0001696	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001696
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006820	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006820
GO_process	GO:0006821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006821
GO_process	GO:0008272	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008272
GO_process	GO:0015701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015701
GO_process	GO:0019532	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019532
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
Gene3D	3.30.750.24	http://www.cathdb.info/version/latest/superfamily/3.30.750.24
GeneCards	SLC26A7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC26A7
GeneID	115111	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=115111
GeneTree	ENSGT00760000119026	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119026
HGNC	HGNC:14467	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14467
HOGENOM	HOG000049231	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000049231&db=HOGENOM6
HOVERGEN	HBG108442	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108442&db=HOVERGEN
InParanoid	Q8TE54	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8TE54
InterPro	IPR001902	http://www.ebi.ac.uk/interpro/entry/IPR001902
InterPro	IPR002645	http://www.ebi.ac.uk/interpro/entry/IPR002645
InterPro	IPR011547	http://www.ebi.ac.uk/interpro/entry/IPR011547
InterPro	IPR030329	http://www.ebi.ac.uk/interpro/entry/IPR030329
Jabion	115111	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=115111
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:115111	http://www.genome.jp/dbget-bin/www_bget?hsa:115111
KEGG_Orthology	KO:K13962	http://www.genome.jp/dbget-bin/www_bget?KO:K13962
KEGG_Pathway	ko04971	http://www.genome.jp/kegg-bin/show_pathway?ko04971
MIM	608479	http://www.ncbi.nlm.nih.gov/omim/608479
OMA	DYSGVSM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DYSGVSM
OrthoDB	EOG091G07RT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07RT
PANTHER	PTHR11814	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11814
PANTHER	PTHR11814:SF75	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11814:SF75
PROSITE	PS50801	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50801
PSORT	swissprot:S26A7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S26A7_HUMAN
PSORT-B	swissprot:S26A7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S26A7_HUMAN
PSORT2	swissprot:S26A7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S26A7_HUMAN
Pfam	PF00916	http://pfam.xfam.org/family/PF00916
Pfam	PF01740	http://pfam.xfam.org/family/PF01740
PharmGKB	PA37884	http://www.pharmgkb.org/do/serve?objId=PA37884&objCls=Gene
Phobius	swissprot:S26A7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S26A7_HUMAN
PhylomeDB	Q8TE54	http://phylomedb.org/?seqid=Q8TE54
ProteinModelPortal	Q8TE54	http://www.proteinmodelportal.org/query/uniprot/Q8TE54
PubMed	11829495	http://www.ncbi.nlm.nih.gov/pubmed/11829495
PubMed	11834742	http://www.ncbi.nlm.nih.gov/pubmed/11834742
PubMed	12736153	http://www.ncbi.nlm.nih.gov/pubmed/12736153
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15956810	http://www.ncbi.nlm.nih.gov/pubmed/15956810
PubMed	16524946	http://www.ncbi.nlm.nih.gov/pubmed/16524946
PubMed	17504921	http://www.ncbi.nlm.nih.gov/pubmed/17504921
Reactome	R-HSA-427601	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-427601
RefSeq	NP_001269285	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269285
RefSeq	NP_001269286	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269286
RefSeq	NP_439897	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_439897
RefSeq	NP_599028	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_599028
STRING	9606.ENSP00000309504	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000309504&targetmode=cogs
SUPFAM	SSF52091	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52091
TCDB	2.A.53.2	http://www.tcdb.org/search/result.php?tc=2.A.53.2
UCSC	uc003yex	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003yex&org=rat
UniGene	Hs.354013	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.354013
UniProtKB	S26A7_HUMAN	http://www.uniprot.org/uniprot/S26A7_HUMAN
UniProtKB-AC	Q8TE54	http://www.uniprot.org/uniprot/Q8TE54
charge	swissprot:S26A7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S26A7_HUMAN
eggNOG	COG0659	http://eggnogapi.embl.de/nog_data/html/tree/COG0659
eggNOG	KOG0236	http://eggnogapi.embl.de/nog_data/html/tree/KOG0236
epestfind	swissprot:S26A7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S26A7_HUMAN
garnier	swissprot:S26A7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S26A7_HUMAN
helixturnhelix	swissprot:S26A7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S26A7_HUMAN
hmoment	swissprot:S26A7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S26A7_HUMAN
iep	swissprot:S26A7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S26A7_HUMAN
inforesidue	swissprot:S26A7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S26A7_HUMAN
neXtProt	NX_Q8TE54	http://www.nextprot.org/db/entry/NX_Q8TE54
octanol	swissprot:S26A7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S26A7_HUMAN
pepcoil	swissprot:S26A7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S26A7_HUMAN
pepdigest	swissprot:S26A7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S26A7_HUMAN
pepinfo	swissprot:S26A7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S26A7_HUMAN
pepnet	swissprot:S26A7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S26A7_HUMAN
pepstats	swissprot:S26A7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S26A7_HUMAN
pepwheel	swissprot:S26A7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S26A7_HUMAN
pepwindow	swissprot:S26A7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S26A7_HUMAN
sigcleave	swissprot:S26A7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S26A7_HUMAN
## Database	ID	URL or Descriptions
# AltName	NTCP_HUMAN	Cell growth-inhibiting gene 29 protein
# AltName	NTCP_HUMAN	Na(+)/bile acid cotransporter
# AltName	NTCP_HUMAN	Na(+)/taurocholate transport protein
# AltName	NTCP_HUMAN	Sodium/taurocholate cotransporting polypeptide
# AltName	NTCP_HUMAN	Solute carrier family 10 member 1
# DrugBank	DB00091	Cyclosporine
# DrugBank	DB00279	Liothyronine
# DrugBank	DB00286	Conjugated Estrogens
# DrugBank	DB00328	Indomethacin
# DrugBank	DB00396	Progesterone
# DrugBank	DB00624	Testosterone
# DrugBank	DB00887	Bumetanide
# DrugBank	DB00977	Ethinyl Estradiol
# DrugBank	DB01032	Probenecid
# DrugBank	DB01583	Liotrix
# DrugBank	DB01586	Ursodeoxycholic acid
# DrugBank	DB02659	Cholic Acid
# DrugBank	DB03619	Deoxycholic Acid
# DrugBank	DB08860	Pitavastatin
# Ensembl	ENST00000216540	ENSP00000216540; ENSG00000100652
# FUNCTION	NTCP_HUMAN	(Microbial infection) Acts as a receptor for hepatitis B virus. {ECO 0000269|PubMed 23150796}. 
# FUNCTION	NTCP_HUMAN	The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:Ensembl.
# GO_function	GO:0001618	virus receptor activity; IEA:UniProtKB-KW.
# GO_function	NTCP_HUMAN	GO 0008508 bile acid sodium symporter activity; TAS Reactome.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0015721	bile acid and bile salt transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q14973	HS
# HGNC	HGNC:10905	SLC10A1
# InterPro	IPR002657:BilAc	Na_symport/Acr3
# InterPro	IPR004710:Bilac	Na_transpt
# InterPro	IPR030208	SLC10A1
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04976	Bile secretion
# MIM	182396	gene
# Organism	NTCP_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10361	PTHR10361
# PANTHER	PTHR10361:SF40	PTHR10361:SF40
# PIR	I55601	I55601
# Pfam	PF01758	SBF
# Proteomes	UP000005640	Chromosome 14
# Reactome	R-HSA-159418	Recycling of bile acids and salts
# RecName	NTCP_HUMAN	Sodium/bile acid cotransporter
# RefSeq	NP_003040	NM_003049.3
# SIMILARITY	Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	NTCP_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	(Microbial infection) Interacts with hepatitis B virus large envelope protein. {ECO:0000269|PubMed	23150796}. 
# TCDB	2.A.28.1:the bile acid	na(+) symporter (bass) family
# TIGRFAMs	TIGR00841	bass
# UCSC	uc001xlr	human
# eggNOG	COG0385	LUCA
# eggNOG	KOG2718	Eukaryota
BLAST	swissprot:NTCP_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NTCP_HUMAN
BioCyc	ZFISH:ENSG00000100652-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000100652-MONOMER
COXPRESdb	6554	http://coxpresdb.jp/data/gene/6554.shtml
CleanEx	HS_SLC10A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC10A1
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1172/JCI117091	http://dx.doi.org/10.1172/JCI117091
DOI	10.7554/eLife.00049	http://dx.doi.org/10.7554/eLife.00049
DrugBank	DB00091	http://www.drugbank.ca/drugs/DB00091
DrugBank	DB00279	http://www.drugbank.ca/drugs/DB00279
DrugBank	DB00286	http://www.drugbank.ca/drugs/DB00286
DrugBank	DB00328	http://www.drugbank.ca/drugs/DB00328
DrugBank	DB00396	http://www.drugbank.ca/drugs/DB00396
DrugBank	DB00624	http://www.drugbank.ca/drugs/DB00624
DrugBank	DB00887	http://www.drugbank.ca/drugs/DB00887
DrugBank	DB00977	http://www.drugbank.ca/drugs/DB00977
DrugBank	DB01032	http://www.drugbank.ca/drugs/DB01032
DrugBank	DB01583	http://www.drugbank.ca/drugs/DB01583
DrugBank	DB01586	http://www.drugbank.ca/drugs/DB01586
DrugBank	DB02659	http://www.drugbank.ca/drugs/DB02659
DrugBank	DB03619	http://www.drugbank.ca/drugs/DB03619
DrugBank	DB08860	http://www.drugbank.ca/drugs/DB08860
EMBL	AY544127	http://www.ebi.ac.uk/ena/data/view/AY544127
EMBL	BC069799	http://www.ebi.ac.uk/ena/data/view/BC069799
EMBL	BC069822	http://www.ebi.ac.uk/ena/data/view/BC069822
EMBL	BC074724	http://www.ebi.ac.uk/ena/data/view/BC074724
EMBL	BC126298	http://www.ebi.ac.uk/ena/data/view/BC126298
EMBL	BC136355	http://www.ebi.ac.uk/ena/data/view/BC136355
EMBL	CH471061	http://www.ebi.ac.uk/ena/data/view/CH471061
EMBL	L21893	http://www.ebi.ac.uk/ena/data/view/L21893
Ensembl	ENST00000216540	http://www.ensembl.org/id/ENST00000216540
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_function	GO:0001618	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001618
GO_function	GO:0008508	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008508
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0015721	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015721
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC10A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC10A1
GeneID	6554	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6554
GeneTree	ENSGT00550000074505	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074505
HGNC	HGNC:10905	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10905
HOGENOM	HOG000234524	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234524&db=HOGENOM6
HOVERGEN	HBG101123	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG101123&db=HOVERGEN
HPA	HPA042727	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042727
InParanoid	Q14973	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q14973
IntAct	Q14973	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q14973*
InterPro	IPR002657	http://www.ebi.ac.uk/interpro/entry/IPR002657
InterPro	IPR004710	http://www.ebi.ac.uk/interpro/entry/IPR004710
InterPro	IPR030208	http://www.ebi.ac.uk/interpro/entry/IPR030208
Jabion	6554	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6554
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6554	http://www.genome.jp/dbget-bin/www_bget?hsa:6554
KEGG_Orthology	KO:K14341	http://www.genome.jp/dbget-bin/www_bget?KO:K14341
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
MIM	182396	http://www.ncbi.nlm.nih.gov/omim/182396
OMA	KIKAHFW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KIKAHFW
OrthoDB	EOG091G0GT5	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0GT5
PANTHER	PTHR10361	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10361
PANTHER	PTHR10361:SF40	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10361:SF40
PSORT	swissprot:NTCP_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NTCP_HUMAN
PSORT-B	swissprot:NTCP_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NTCP_HUMAN
PSORT2	swissprot:NTCP_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NTCP_HUMAN
Pfam	PF01758	http://pfam.xfam.org/family/PF01758
PharmGKB	PA317	http://www.pharmgkb.org/do/serve?objId=PA317&objCls=Gene
Phobius	swissprot:NTCP_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NTCP_HUMAN
PhylomeDB	Q14973	http://phylomedb.org/?seqid=Q14973
ProteinModelPortal	Q14973	http://www.proteinmodelportal.org/query/uniprot/Q14973
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	23150796	http://www.ncbi.nlm.nih.gov/pubmed/23150796
PubMed	8132774	http://www.ncbi.nlm.nih.gov/pubmed/8132774
Reactome	R-HSA-159418	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-159418
RefSeq	NP_003040	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003040
STRING	9606.ENSP00000216540	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000216540&targetmode=cogs
TCDB	2.A.28.1	http://www.tcdb.org/search/result.php?tc=2.A.28.1
TIGRFAMs	TIGR00841	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00841
UCSC	uc001xlr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001xlr&org=rat
UniGene	Hs.952	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.952
UniProtKB	NTCP_HUMAN	http://www.uniprot.org/uniprot/NTCP_HUMAN
UniProtKB-AC	Q14973	http://www.uniprot.org/uniprot/Q14973
charge	swissprot:NTCP_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NTCP_HUMAN
eggNOG	COG0385	http://eggnogapi.embl.de/nog_data/html/tree/COG0385
eggNOG	KOG2718	http://eggnogapi.embl.de/nog_data/html/tree/KOG2718
epestfind	swissprot:NTCP_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NTCP_HUMAN
garnier	swissprot:NTCP_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NTCP_HUMAN
helixturnhelix	swissprot:NTCP_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NTCP_HUMAN
hmoment	swissprot:NTCP_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NTCP_HUMAN
iep	swissprot:NTCP_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NTCP_HUMAN
inforesidue	swissprot:NTCP_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NTCP_HUMAN
neXtProt	NX_Q14973	http://www.nextprot.org/db/entry/NX_Q14973
octanol	swissprot:NTCP_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NTCP_HUMAN
pepcoil	swissprot:NTCP_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NTCP_HUMAN
pepdigest	swissprot:NTCP_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NTCP_HUMAN
pepinfo	swissprot:NTCP_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NTCP_HUMAN
pepnet	swissprot:NTCP_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NTCP_HUMAN
pepstats	swissprot:NTCP_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NTCP_HUMAN
pepwheel	swissprot:NTCP_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NTCP_HUMAN
pepwindow	swissprot:NTCP_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NTCP_HUMAN
sigcleave	swissprot:NTCP_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NTCP_HUMAN
## Database	ID	URL or Descriptions
# AltName	IMA1_HUMAN	Karyopherin subunit alpha-2
# AltName	IMA1_HUMAN	RAG cohort protein 1
# AltName	IMA1_HUMAN	SRP1-alpha
# BioGrid	110036	188
# ChiTaRS	KPNA2	human
# DOMAIN	IMA1_HUMAN	Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import. {ECO 0000269|PubMed 8617227}. 
# DOMAIN	IMA1_HUMAN	The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS- containing proteins (By similarity). {ECO 0000250}. 
# DOMAIN	IMA1_HUMAN	The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity). {ECO 0000250}. 
# Ensembl	ENST00000330459	ENSP00000332455; ENSG00000182481
# Ensembl	ENST00000537025	ENSP00000438483; ENSG00000182481
# ExpressionAtlas	P52292	baseline and differential
# FUNCTION	IMA1_HUMAN	Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. 
# GO_component	GO:0005643	nuclear pore; IBA:GO_Central.
# GO_component	GO:0005654	nucleoplasm; IDA:HPA.
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0005829	cytosol; IBA:GO_Central.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_function	GO:0008139	nuclear localization sequence binding; IDA:UniProtKB.
# GO_function	GO:0008565	protein transporter activity; IBA:GO_Central.
# GO_function	GO:0042826	histone deacetylase binding; IPI:BHF-UCL.
# GO_function	GO:0044822	poly(A) RNA binding; IDA:UniProtKB.
# GO_process	GO:0000018	regulation of DNA recombination; TAS:ProtInc.
# GO_process	GO:0006259	DNA metabolic process; TAS:ProtInc.
# GO_process	GO:0006607	NLS-bearing protein import into nucleus; IDA:UniProtKB.
# GO_process	GO:0019054	modulation by virus of host process; TAS:Reactome.
# GO_process	GO:0075733	intracellular transport of virus; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0003723	RNA binding
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_process	GO:0006259	DNA metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# Gene3D	1.25.10.10	-; 1.
# Genevisible	P52292	HS
# HGNC	HGNC:6395	KPNA2
# INTERACTION	IMA1_HUMAN	P38398 BRCA1; NbExp=3; IntAct=EBI-349938, EBI-349905; P05412 JUN; NbExp=4; IntAct=EBI-349938, EBI-852823; P03101 L1 (xeno); NbExp=3; IntAct=EBI-349938, EBI-7362698; P03107 L2 (xeno); NbExp=3; IntAct=EBI-349938, EBI-7362531; Q6GQG6 npm2 (xeno); NbExp=2; IntAct=EBI-349938, EBI-8469111; Q9UKX7 NUP50; NbExp=3; IntAct=EBI-349938, EBI-2371082; P46063 RECQL; NbExp=2; IntAct=EBI-349938, EBI-2823728; P04620 rev (xeno); NbExp=2; IntAct=EBI-349938, EBI-10687101; P29034 S100A2; NbExp=5; IntAct=EBI-349938, EBI-752230; P06703 S100A6; NbExp=3; IntAct=EBI-349938, EBI-352877; Q15637 SF1; NbExp=5; IntAct=EBI-349938, EBI-744603; Q9UH99 SUN2; NbExp=3; IntAct=EBI-349938, EBI-1044964; 
# IntAct	P52292	93
# InterPro	IPR000225	Armadillo
# InterPro	IPR002652	Importin-a_IBB
# InterPro	IPR011989	ARM-like
# InterPro	IPR016024	ARM-type_fold
# InterPro	IPR024931	Importing_su_alpha
# InterPro	IPR032413	Arm_3
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko03036	 Chromosome
# KEGG_Pathway	ko05164	Influenza A
# MASS SPECTROMETRY	Mass=57861.92; Method=MALDI; Range=1-529; Evidence={ECO:0000269|PubMed	11840567}; 
# MIM	600685	gene
# Organism	IMA1_HUMAN	Homo sapiens (Human)
# PDB	1EFX	X-ray; 3.00 A; C=204-212
# PDB	1QGK	X-ray; 2.50 A; B=11-54
# PDB	1QGR	X-ray; 2.30 A; B=28-54
# PDB	3FEX	X-ray; 3.55 A; C=70-529
# PDB	3FEY	X-ray; 2.20 A; C=70-529
# PDB	3WPT	X-ray; 2.63 A; A/B=75-497
# PDB	4E4V	X-ray; 2.53 A; A/B=70-529
# PDB	4WV6	X-ray; 1.75 A; A=60-529
# PIR	A56516	A56516
# PIRSF	PIRSF005673	Importin_alpha
# PROSITE	PS50176	ARM_REPEAT; 5
# PROSITE	PS51214	IBB
# Pfam	PF00514	Arm; 8
# Pfam	PF01749	IBB
# Pfam	PF16186	Arm_3
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-1169408	ISG15 antiviral mechanism
# Reactome	R-HSA-168276	NS1 Mediated Effects on Host Pathways
# Reactome	R-HSA-5693548	Sensing of DNA Double Strand Breaks
# RecName	IMA1_HUMAN	Importin subunit alpha-1
# RefSeq	NP_001307540	NM_001320611.1
# RefSeq	NP_002257	NM_002266.3
# SIMILARITY	Belongs to the importin alpha family. {ECO	0000305}. 
# SIMILARITY	Contains 1 IBB domain. {ECO:0000255|PROSITE- ProRule	PRU00561}.
# SIMILARITY	Contains 10 ARM repeats. {ECO:0000255|PROSITE- ProRule	PRU00259}. 
# SMART	SM00185	ARM; 8
# SUBCELLULAR LOCATION	IMA1_HUMAN	Cytoplasm {ECO 0000269|PubMed 7604027}. Nucleus {ECO 0000269|PubMed 7604027}. 
# SUBUNIT	IMA1_HUMAN	Heterodimer; with KPNB1. Interacts with ANP32E (By similarity). Component of a complex containing CSE1L, RAN and KPNA2. Interacts directly with CSE1L. Interacts with HIV-1 Vpr and PLAG1. Interacts with APEX1 (via N-terminus). Interacts with FRG1 (via N-terminus). Interacts with ARL4A, CTNNBL1 and NBN. Interacts with SNAI1 (via zinc fingers) and SNAI2 (via zinc fingers). {ECO 0000250, ECO 0000269|PubMed 10980193, ECO 0000269|PubMed 11882654, ECO 0000269|PubMed 15942031, ECO 0000269|PubMed 16188882, ECO 0000269|PubMed 19386897, ECO 0000269|PubMed 21385873, ECO 0000269|PubMed 21454664, ECO 0000269|PubMed 21699900, ECO 0000269|PubMed 7604027, ECO 0000269|PubMed 9323134, ECO 0000269|PubMed 9463369, ECO 0000269|PubMed 9786944}. 
# SUPFAM	SSF48371	SSF48371
# TCDB	1.I.1.1	the nuclear pore complex (npc) family
# TISSUE SPECIFICITY	IMA1_HUMAN	Expressed ubiquitously. 
# UCSC	uc002jgk	human
# eggNOG	COG5064	LUCA
# eggNOG	KOG0166	Eukaryota
BLAST	swissprot:IMA1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:IMA1_HUMAN
BioCyc	ZFISH:G66-32671-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32671-MONOMER
COXPRESdb	3838	http://coxpresdb.jp/data/gene/3838.shtml
CleanEx	HS_KPNA2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KPNA2
DIP	DIP-6205N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-6205N
DOI	10.1002/1615-9861(200202)2:2<212::AID-PROT212>3.0.CO	http://dx.doi.org/10.1002/1615-9861(200202)2:2<212::AID-PROT212>3.0.CO
DOI	10.1007/s004390100605	http://dx.doi.org/10.1007/s004390100605
DOI	10.1016/S0092-8674(00)80372-4	http://dx.doi.org/10.1016/S0092-8674(00)80372-4
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.jmb.2011.06.014	http://dx.doi.org/10.1016/j.jmb.2011.06.014
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr0705441	http://dx.doi.org/10.1021/pr0705441
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/20367	http://dx.doi.org/10.1038/20367
DOI	10.1038/nbt1240	http://dx.doi.org/10.1038/nbt1240
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1073/pnas.91.13.6156	http://dx.doi.org/10.1073/pnas.91.13.6156
DOI	10.1073/pnas.92.14.6532	http://dx.doi.org/10.1073/pnas.92.14.6532
DOI	10.1074/jbc.M002470200	http://dx.doi.org/10.1074/jbc.M002470200
DOI	10.1074/jbc.M110.208769	http://dx.doi.org/10.1074/jbc.M110.208769
DOI	10.1074/jbc.M110.213579	http://dx.doi.org/10.1074/jbc.M110.213579
DOI	10.1074/jbc.M112112200	http://dx.doi.org/10.1074/jbc.M112112200
DOI	10.1074/jbc.M508425200	http://dx.doi.org/10.1074/jbc.M508425200
DOI	10.1083/jcb.143.2.309	http://dx.doi.org/10.1083/jcb.143.2.309
DOI	10.1093/emboj/17.4.909	http://dx.doi.org/10.1093/emboj/17.4.909
DOI	10.1093/nar/gki641	http://dx.doi.org/10.1093/nar/gki641
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.7754385	http://dx.doi.org/10.1126/science.7754385
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1242/jcs.041749	http://dx.doi.org/10.1242/jcs.041749
EMBL	AJ303086	http://www.ebi.ac.uk/ena/data/view/AJ303086
EMBL	BC005978	http://www.ebi.ac.uk/ena/data/view/BC005978
EMBL	BC146905	http://www.ebi.ac.uk/ena/data/view/BC146905
EMBL	BT006665	http://www.ebi.ac.uk/ena/data/view/BT006665
EMBL	CH471099	http://www.ebi.ac.uk/ena/data/view/CH471099
EMBL	U09559	http://www.ebi.ac.uk/ena/data/view/U09559
EMBL	U28386	http://www.ebi.ac.uk/ena/data/view/U28386
Ensembl	ENST00000330459	http://www.ensembl.org/id/ENST00000330459
Ensembl	ENST00000537025	http://www.ensembl.org/id/ENST00000537025
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005643	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005643
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0008139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008139
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0042826	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042826
GO_function	GO:0044822	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044822
GO_process	GO:0000018	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000018
GO_process	GO:0006259	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GO_process	GO:0006607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006607
GO_process	GO:0019054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019054
GO_process	GO:0075733	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0075733
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0003723	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_process	GO:0006259	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
GeneCards	KPNA2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KPNA2
GeneID	3838	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3838
GeneTree	ENSGT00760000119094	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119094
HGNC	HGNC:6395	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6395
HOGENOM	HOG000167616	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000167616&db=HOGENOM6
HOVERGEN	HBG001846	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG001846&db=HOVERGEN
HPA	CAB015460	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB015460
HPA	HPA041270	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA041270
InParanoid	P52292	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52292
IntAct	P52292	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52292*
InterPro	IPR000225	http://www.ebi.ac.uk/interpro/entry/IPR000225
InterPro	IPR002652	http://www.ebi.ac.uk/interpro/entry/IPR002652
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
InterPro	IPR024931	http://www.ebi.ac.uk/interpro/entry/IPR024931
InterPro	IPR032413	http://www.ebi.ac.uk/interpro/entry/IPR032413
Jabion	3838	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3838
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko03036	http://www.genome.jp/dbget-bin/www_bget?ko03036
KEGG_Gene	hsa:3838	http://www.genome.jp/dbget-bin/www_bget?hsa:3838
KEGG_Orthology	KO:K15043	http://www.genome.jp/dbget-bin/www_bget?KO:K15043
KEGG_Pathway	ko05164	http://www.genome.jp/kegg-bin/show_pathway?ko05164
MIM	600685	http://www.ncbi.nlm.nih.gov/omim/600685
MINT	MINT-94121	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-94121
OMA	IVPICIR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IVPICIR
OrthoDB	EOG091G095Z	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G095Z
PDB	1EFX	http://www.ebi.ac.uk/pdbe-srv/view/entry/1EFX
PDB	1QGK	http://www.ebi.ac.uk/pdbe-srv/view/entry/1QGK
PDB	1QGR	http://www.ebi.ac.uk/pdbe-srv/view/entry/1QGR
PDB	3FEX	http://www.ebi.ac.uk/pdbe-srv/view/entry/3FEX
PDB	3FEY	http://www.ebi.ac.uk/pdbe-srv/view/entry/3FEY
PDB	3WPT	http://www.ebi.ac.uk/pdbe-srv/view/entry/3WPT
PDB	4E4V	http://www.ebi.ac.uk/pdbe-srv/view/entry/4E4V
PDB	4WV6	http://www.ebi.ac.uk/pdbe-srv/view/entry/4WV6
PDBsum	1EFX	http://www.ebi.ac.uk/pdbsum/1EFX
PDBsum	1QGK	http://www.ebi.ac.uk/pdbsum/1QGK
PDBsum	1QGR	http://www.ebi.ac.uk/pdbsum/1QGR
PDBsum	3FEX	http://www.ebi.ac.uk/pdbsum/3FEX
PDBsum	3FEY	http://www.ebi.ac.uk/pdbsum/3FEY
PDBsum	3WPT	http://www.ebi.ac.uk/pdbsum/3WPT
PDBsum	4E4V	http://www.ebi.ac.uk/pdbsum/4E4V
PDBsum	4WV6	http://www.ebi.ac.uk/pdbsum/4WV6
PROSITE	PS50176	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50176
PROSITE	PS51214	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51214
PSORT	swissprot:IMA1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:IMA1_HUMAN
PSORT-B	swissprot:IMA1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:IMA1_HUMAN
PSORT2	swissprot:IMA1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:IMA1_HUMAN
Pfam	PF00514	http://pfam.xfam.org/family/PF00514
Pfam	PF01749	http://pfam.xfam.org/family/PF01749
Pfam	PF16186	http://pfam.xfam.org/family/PF16186
PharmGKB	PA30186	http://www.pharmgkb.org/do/serve?objId=PA30186&objCls=Gene
Phobius	swissprot:IMA1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:IMA1_HUMAN
PhylomeDB	P52292	http://phylomedb.org/?seqid=P52292
ProteinModelPortal	P52292	http://www.proteinmodelportal.org/query/uniprot/P52292
PubMed	10353244	http://www.ncbi.nlm.nih.gov/pubmed/10353244
PubMed	10980193	http://www.ncbi.nlm.nih.gov/pubmed/10980193
PubMed	11735022	http://www.ncbi.nlm.nih.gov/pubmed/11735022
PubMed	11840567	http://www.ncbi.nlm.nih.gov/pubmed/11840567
PubMed	11882654	http://www.ncbi.nlm.nih.gov/pubmed/11882654
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15942031	http://www.ncbi.nlm.nih.gov/pubmed/15942031
PubMed	16188882	http://www.ncbi.nlm.nih.gov/pubmed/16188882
PubMed	16964243	http://www.ncbi.nlm.nih.gov/pubmed/16964243
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	18220336	http://www.ncbi.nlm.nih.gov/pubmed/18220336
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	19386897	http://www.ncbi.nlm.nih.gov/pubmed/19386897
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21385873	http://www.ncbi.nlm.nih.gov/pubmed/21385873
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	21454664	http://www.ncbi.nlm.nih.gov/pubmed/21454664
PubMed	21699900	http://www.ncbi.nlm.nih.gov/pubmed/21699900
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	7604027	http://www.ncbi.nlm.nih.gov/pubmed/7604027
PubMed	7754385	http://www.ncbi.nlm.nih.gov/pubmed/7754385
PubMed	8016130	http://www.ncbi.nlm.nih.gov/pubmed/8016130
PubMed	8617227	http://www.ncbi.nlm.nih.gov/pubmed/8617227
PubMed	9323134	http://www.ncbi.nlm.nih.gov/pubmed/9323134
PubMed	9463369	http://www.ncbi.nlm.nih.gov/pubmed/9463369
PubMed	9786944	http://www.ncbi.nlm.nih.gov/pubmed/9786944
Reactome	R-HSA-1169408	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1169408
Reactome	R-HSA-168276	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-168276
Reactome	R-HSA-5693548	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5693548
RefSeq	NP_001307540	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001307540
RefSeq	NP_002257	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002257
SMART	SM00185	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00185
SMR	P52292	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52292
STRING	9606.ENSP00000332455	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000332455&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
SWISS-2DPAGE	P52292	http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P52292
TCDB	1.I.1.1	http://www.tcdb.org/search/result.php?tc=1.I.1.1
UCSC	uc002jgk	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002jgk&org=rat
UniGene	Hs.594238	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.594238
UniProtKB	IMA1_HUMAN	http://www.uniprot.org/uniprot/IMA1_HUMAN
UniProtKB-AC	P52292	http://www.uniprot.org/uniprot/P52292
charge	swissprot:IMA1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:IMA1_HUMAN
eggNOG	COG5064	http://eggnogapi.embl.de/nog_data/html/tree/COG5064
eggNOG	KOG0166	http://eggnogapi.embl.de/nog_data/html/tree/KOG0166
epestfind	swissprot:IMA1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:IMA1_HUMAN
garnier	swissprot:IMA1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:IMA1_HUMAN
helixturnhelix	swissprot:IMA1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:IMA1_HUMAN
hmoment	swissprot:IMA1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:IMA1_HUMAN
iep	swissprot:IMA1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:IMA1_HUMAN
inforesidue	swissprot:IMA1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:IMA1_HUMAN
neXtProt	NX_P52292	http://www.nextprot.org/db/entry/NX_P52292
octanol	swissprot:IMA1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:IMA1_HUMAN
pepcoil	swissprot:IMA1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:IMA1_HUMAN
pepdigest	swissprot:IMA1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:IMA1_HUMAN
pepinfo	swissprot:IMA1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:IMA1_HUMAN
pepnet	swissprot:IMA1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:IMA1_HUMAN
pepstats	swissprot:IMA1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:IMA1_HUMAN
pepwheel	swissprot:IMA1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:IMA1_HUMAN
pepwindow	swissprot:IMA1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:IMA1_HUMAN
sigcleave	swissprot:IMA1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:IMA1_HUMAN
## Database	ID	URL or Descriptions
# AltName	NMUR2_HUMAN	G-protein coupled receptor FM-4
# AltName	NMUR2_HUMAN	G-protein coupled receptor TGR-1
# BioGrid	121250	25
# CAUTION	It is uncertain whether Met-1 or Met-4 is the initiator. {ECO	0000305}. 
# Ensembl	ENST00000255262	ENSP00000255262; ENSG00000132911
# FUNCTION	NMUR2_HUMAN	Receptor for the neuromedin-U and neuromedin-S neuropeptides. {ECO 0000250, ECO 0000269|PubMed 10899166}. 
# GO_component	GO:0005622	intracellular; IEA:GOC.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IDA:UniProtKB.
# GO_function	GO:0001607	neuromedin U receptor activity; IDA:UniProtKB.
# GO_function	GO:0004930	G-protein coupled receptor activity; TAS:ProtInc.
# GO_function	GO:0005229	intracellular calcium activated chloride channel activity; IDA:UniProtKB.
# GO_function	GO:0005525	GTP binding; IDA:UniProtKB.
# GO_function	GO:0042924	neuromedin U binding; IDA:UniProtKB.
# GO_process	GO:0002023	reduction of food intake in response to dietary excess; IEA:Ensembl.
# GO_process	GO:0006816	calcium ion transport; IDA:UniProtKB.
# GO_process	GO:0006940	regulation of smooth muscle contraction; NAS:UniProtKB.
# GO_process	GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway; IDA:UniProtKB.
# GO_process	GO:0007204	positive regulation of cytosolic calcium ion concentration; IDA:UniProtKB.
# GO_process	GO:0007218	neuropeptide signaling pathway; TAS:ProtInc.
# GO_process	GO:0007267	cell-cell signaling; TAS:ProtInc.
# GO_process	GO:0007417	central nervous system development; IEP:UniProtKB.
# GO_process	GO:0007625	grooming behavior; IEA:Ensembl.
# GO_process	GO:0007631	feeding behavior; TAS:ProtInc.
# GO_process	GO:0019722	calcium-mediated signaling; NAS:UniProtKB.
# GO_process	GO:0043006	activation of phospholipase A2 activity by calcium-mediated signaling; IDA:UniProtKB.
# GO_process	GO:0048016	inositol phosphate-mediated signaling; IDA:UniProtKB.
# GO_process	GO:0048265	response to pain; IEA:Ensembl.
# GO_process	GO:0050482	arachidonic acid secretion; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005622	intracellular
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# Genevisible	Q9GZQ4	HS
# HGNC	HGNC:16454	NMUR2
# INTERACTION	NMUR2_HUMAN	Q6UY14-3 ADAMTSL4; NbExp=3; IntAct=EBI-10303844, EBI-10173507; P15884 TCF4; NbExp=3; IntAct=EBI-10303844, EBI-533224; Q12933 TRAF2; NbExp=3; IntAct=EBI-10303844, EBI-355744; 
# IntAct	Q9GZQ4	4
# InterPro	IPR000276	GPCR_Rhodpsn
# InterPro	IPR005390	NeuromedU_rcpt
# InterPro	IPR005392	NeuromedU_rcpt_2
# InterPro	IPR017452	GPCR_Rhodpsn_7TM
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04030	 G protein-coupled receptors
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# MIM	605108	gene
# Organism	NMUR2_HUMAN	Homo sapiens (Human)
# PRINTS	PR00237	GPCRRHODOPSN
# PRINTS	PR01565	NEUROMEDINUR
# PRINTS	PR01567	NEUROMEDNU2R
# PROSITE	PS00237	G_PROTEIN_RECEP_F1_1
# PROSITE	PS50262	G_PROTEIN_RECEP_F1_2
# Pfam	PF00001	7tm_1
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-375276	Peptide ligand-binding receptors
# Reactome	R-HSA-416476	G alpha (q) signalling events
# Reactome	R-HSA-418594	G alpha (i) signalling events
# RecName	NMUR2_HUMAN	Neuromedin-U receptor 2
# RefSeq	NP_064552	NM_020167.4
# SEQUENCE CAUTION	Sequence=BAB13721.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule	PRU00521}. 
# SMART	SM01381	7TM_GPCR_Srsx
# SUBCELLULAR LOCATION	NMUR2_HUMAN	Cell membrane; Multi-pass membrane protein. 
# TISSUE SPECIFICITY	NMUR2_HUMAN	Predominantly expressed in the CNS, particularly in the medulla oblongata, pontine reticular formation, spinal cord, and thalamus. High level in testis whereas lower levels are present in a variety of peripheral tissues including the gastrointestinal tract, genitourinary tract, liver, pancreas, adrenal gland, thyroid gland, lung, trachea, spleen and thymus. {ECO 0000269|PubMed 10887190, ECO 0000269|PubMed 10894543, ECO 0000269|PubMed 10899166, ECO 0000269|PubMed 11010960}. 
# UCSC	uc003luv	human
# eggNOG	ENOG410XRW9	LUCA
# eggNOG	KOG3656	Eukaryota
BLAST	swissprot:NMUR2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NMUR2_HUMAN
COXPRESdb	56923	http://coxpresdb.jp/data/gene/56923.shtml
CleanEx	HS_NMUR2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_NMUR2
DOI	10.1038/35017610	http://dx.doi.org/10.1038/35017610
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1074/jbc.C000522200	http://dx.doi.org/10.1074/jbc.C000522200
DOI	10.1074/jbc.M004261200	http://dx.doi.org/10.1074/jbc.M004261200
DOI	10.1074/jbc.M004613200	http://dx.doi.org/10.1074/jbc.M004613200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB041228	http://www.ebi.ac.uk/ena/data/view/AB041228
EMBL	AC008571	http://www.ebi.ac.uk/ena/data/view/AC008571
EMBL	AF242874	http://www.ebi.ac.uk/ena/data/view/AF242874
EMBL	AF272363	http://www.ebi.ac.uk/ena/data/view/AF272363
EMBL	AF292402	http://www.ebi.ac.uk/ena/data/view/AF292402
EMBL	BC016938	http://www.ebi.ac.uk/ena/data/view/BC016938
EMBL	BC067776	http://www.ebi.ac.uk/ena/data/view/BC067776
Ensembl	ENST00000255262	http://www.ensembl.org/id/ENST00000255262
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0001607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001607
GO_function	GO:0004930	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004930
GO_function	GO:0005229	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005229
GO_function	GO:0005525	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525
GO_function	GO:0042924	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042924
GO_process	GO:0002023	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002023
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0006940	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006940
GO_process	GO:0007200	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007200
GO_process	GO:0007204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007204
GO_process	GO:0007218	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007218
GO_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GO_process	GO:0007417	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007417
GO_process	GO:0007625	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007625
GO_process	GO:0007631	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007631
GO_process	GO:0019722	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019722
GO_process	GO:0043006	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043006
GO_process	GO:0048016	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048016
GO_process	GO:0048265	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048265
GO_process	GO:0050482	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050482
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GeneCards	NMUR2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=NMUR2
GeneID	56923	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56923
GeneTree	ENSGT00700000104070	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00700000104070
H-InvDB	HIX0005335	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0005335
HGNC	HGNC:16454	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16454
HOGENOM	HOG000113804	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000113804&db=HOGENOM6
HOVERGEN	HBG103506	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG103506&db=HOVERGEN
HPA	HPA045836	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA045836
InParanoid	Q9GZQ4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9GZQ4
IntAct	Q9GZQ4	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9GZQ4*
InterPro	IPR000276	http://www.ebi.ac.uk/interpro/entry/IPR000276
InterPro	IPR005390	http://www.ebi.ac.uk/interpro/entry/IPR005390
InterPro	IPR005392	http://www.ebi.ac.uk/interpro/entry/IPR005392
InterPro	IPR017452	http://www.ebi.ac.uk/interpro/entry/IPR017452
Jabion	56923	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=56923
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04030	http://www.genome.jp/dbget-bin/www_bget?ko04030
KEGG_Gene	hsa:56923	http://www.genome.jp/dbget-bin/www_bget?hsa:56923
KEGG_Orthology	KO:K05053	http://www.genome.jp/dbget-bin/www_bget?KO:K05053
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
MIM	605108	http://www.ncbi.nlm.nih.gov/omim/605108
OMA	HYFPNGS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HYFPNGS
OrthoDB	EOG091G0ZDG	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0ZDG
PRINTS	PR00237	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00237
PRINTS	PR01565	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01565
PRINTS	PR01567	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01567
PROSITE	PS00237	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00237
PROSITE	PS50262	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50262
PSORT	swissprot:NMUR2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NMUR2_HUMAN
PSORT-B	swissprot:NMUR2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NMUR2_HUMAN
PSORT2	swissprot:NMUR2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NMUR2_HUMAN
Pfam	PF00001	http://pfam.xfam.org/family/PF00001
PharmGKB	PA31664	http://www.pharmgkb.org/do/serve?objId=PA31664&objCls=Gene
Phobius	swissprot:NMUR2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NMUR2_HUMAN
PhylomeDB	Q9GZQ4	http://phylomedb.org/?seqid=Q9GZQ4
ProteinModelPortal	Q9GZQ4	http://www.proteinmodelportal.org/query/uniprot/Q9GZQ4
PubMed	10887190	http://www.ncbi.nlm.nih.gov/pubmed/10887190
PubMed	10894543	http://www.ncbi.nlm.nih.gov/pubmed/10894543
PubMed	10899166	http://www.ncbi.nlm.nih.gov/pubmed/10899166
PubMed	11010960	http://www.ncbi.nlm.nih.gov/pubmed/11010960
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-375276	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-375276
Reactome	R-HSA-416476	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-416476
Reactome	R-HSA-418594	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418594
RefSeq	NP_064552	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_064552
SMART	SM01381	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01381
SMR	Q9GZQ4	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9GZQ4
STRING	9606.ENSP00000255262	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000255262&targetmode=cogs
UCSC	uc003luv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003luv&org=rat
UniGene	Hs.731911	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.731911
UniProtKB	NMUR2_HUMAN	http://www.uniprot.org/uniprot/NMUR2_HUMAN
UniProtKB-AC	Q9GZQ4	http://www.uniprot.org/uniprot/Q9GZQ4
charge	swissprot:NMUR2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NMUR2_HUMAN
eggNOG	ENOG410XRW9	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRW9
eggNOG	KOG3656	http://eggnogapi.embl.de/nog_data/html/tree/KOG3656
epestfind	swissprot:NMUR2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NMUR2_HUMAN
garnier	swissprot:NMUR2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NMUR2_HUMAN
helixturnhelix	swissprot:NMUR2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NMUR2_HUMAN
hmoment	swissprot:NMUR2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NMUR2_HUMAN
iep	swissprot:NMUR2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NMUR2_HUMAN
inforesidue	swissprot:NMUR2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NMUR2_HUMAN
neXtProt	NX_Q9GZQ4	http://www.nextprot.org/db/entry/NX_Q9GZQ4
octanol	swissprot:NMUR2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NMUR2_HUMAN
pepcoil	swissprot:NMUR2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NMUR2_HUMAN
pepdigest	swissprot:NMUR2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NMUR2_HUMAN
pepinfo	swissprot:NMUR2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NMUR2_HUMAN
pepnet	swissprot:NMUR2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NMUR2_HUMAN
pepstats	swissprot:NMUR2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NMUR2_HUMAN
pepwheel	swissprot:NMUR2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NMUR2_HUMAN
pepwindow	swissprot:NMUR2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NMUR2_HUMAN
sigcleave	swissprot:NMUR2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NMUR2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TRPV3_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8NET8-1; Sequence=Displayed; Name=2; Synonyms=A; IsoId=Q8NET8-2; Sequence=VSP_013433; Name=3; Synonyms=B; IsoId=Q8NET8-3; Sequence=VSP_013434, VSP_013435; 
# AltName	TRPV3_HUMAN	Vanilloid receptor-like 3
# CCDS	CCDS11029	-. [Q8NET8-1]
# CCDS	CCDS58500	-. [Q8NET8-2]
# DISEASE	TRPV3_HUMAN	Olmsted syndrome (OLMS) [MIM 614594]  A rare congenital disorder characterized by bilateral mutilating palmoplantar keratoderma and periorificial keratotic plaques with severe itching at all lesions. Diffuse alopecia, constriction of digits, and onychodystrophy have also been reported. Infections and squamous cell carcinomas can arise on the keratotic areas. The digital constriction may progress to autoamputation of fingers and toes. {ECO 0000269|PubMed 22405088, ECO 0000269|PubMed 22835024}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	TRPV3_HUMAN	Palmoplantar keratoderma, non-epidermolytic, focal 2 (FNEPPK2) [MIM 616400]  A dermatological disorder characterized by non-epidermolytic, abnormal thickening of the skin on the palms and soles. Focal palmoplantar keratoderma consists of localized areas of hyperkeratosis located mainly on pressure points and sites of recurrent friction. {ECO 0000269|PubMed 25285920}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00825	Menthol
# Ensembl	ENST00000301365	ENSP00000301365; ENSG00000167723. [Q8NET8-2]
# Ensembl	ENST00000572519	ENSP00000460215; ENSG00000167723. [Q8NET8-3]
# Ensembl	ENST00000576742	ENSP00000461518; ENSG00000167723. [Q8NET8-1]
# ExpressionAtlas	Q8NET8	baseline and differential
# FUNCTION	TRPV3_HUMAN	Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling  TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen). {ECO 0000269|PubMed 12077604, ECO 0000269|PubMed 12077606, ECO 0000269|PubMed 21593771}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0043235	receptor complex; IDA:MGI.
# GO_function	GO:0005262	calcium channel activity; IBA:GO_Central.
# GO_process	GO:0009408	response to heat; IEA:Ensembl.
# GO_process	GO:0042636	negative regulation of hair cycle; IMP:UniProtKB.
# GO_process	GO:0070588	calcium ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0090280	positive regulation of calcium ion import; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.25.40.20	-; 1.
# Genevisible	Q8NET8	HS
# HGNC	HGNC:18084	TRPV3
# InterPro	IPR002110	Ankyrin_rpt
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR008347	TRPV1-4_channel
# InterPro	IPR020683	Ankyrin_rpt-contain_dom
# InterPro	IPR024866	TRPV3_channel
# KEGG_Brite	ko04040	Ion channels
# MIM	607066	gene
# MIM	614594	phenotype
# MIM	616400	phenotype
# Organism	TRPV3_HUMAN	Homo sapiens (Human)
# Orphanet	659	Mutilating palmoplantar keratoderma with periorificial keratotic plaques
# PANTHER	PTHR10582:SF6	PTHR10582:SF6
# PRINTS	PR01768	TRPVRECEPTOR
# PROSITE	PS50088	ANK_REPEAT; 2
# PROSITE	PS50297	ANK_REP_REGION
# Pfam	PF00520	Ion_trans
# Pfam	PF12796	Ank_2
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-3295583	TRP channels
# RecName	TRPV3_HUMAN	Transient receptor potential cation channel subfamily V member 3
# RefSeq	NP_659505	NM_145068.3. [Q8NET8-1]
# SIMILARITY	Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV3 sub-subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 3 ANK repeats. {ECO:0000255|PROSITE- ProRule	PRU00023}. 
# SMART	SM00248	ANK; 4
# SUBCELLULAR LOCATION	TRPV3_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	May form a heteromeric channel with TRPV1. Interacts with TRPV1. {ECO:0000269|PubMed	12077606}. 
# SUPFAM	SSF48403	SSF48403
# TCDB	1.A.4.2	the transient receptor potential ca(2+) channel (trp-cc) family
# TISSUE SPECIFICITY	TRPV3_HUMAN	Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion (at protein level). Expressed in the keratinocyte layers of the outer root sheath and, to lesser extent, to the matrix of the hair follicles (at protein level). {ECO 0000269|PubMed 12077604, ECO 0000269|PubMed 12077606, ECO 0000269|PubMed 21593771}. 
# UCSC	uc002fvr	human. [Q8NET8-1]
# WEB RESOURCE	TRPV3_HUMAN	Name=Transient receptor potential cation channel, subfamily V, member 3 (TRPV3); Note=Leiden Open Variation Database (LOVD); URL="http //grenada.lumc.nl/LOVD2/shared1/home.php?select_db=TRPV3";
# eggNOG	ENOG4110DG4	LUCA
# eggNOG	KOG3676	Eukaryota
BLAST	swissprot:TRPV3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TRPV3_HUMAN
COXPRESdb	162514	http://coxpresdb.jp/data/gene/162514.shtml
CleanEx	HS_TRPV3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TRPV3
DOI	10.1016/j.ajhg.2012.02.006	http://dx.doi.org/10.1016/j.ajhg.2012.02.006
DOI	10.1038/jid.2011.122	http://dx.doi.org/10.1038/jid.2011.122
DOI	10.1038/jid.2014.429	http://dx.doi.org/10.1038/jid.2014.429
DOI	10.1038/nature00882	http://dx.doi.org/10.1038/nature00882
DOI	10.1038/nature00894	http://dx.doi.org/10.1038/nature00894
DOI	10.1111/j.1365-2133.2012.11115.x	http://dx.doi.org/10.1111/j.1365-2133.2012.11115.x
DrugBank	DB00825	http://www.drugbank.ca/drugs/DB00825
EMBL	AF514998	http://www.ebi.ac.uk/ena/data/view/AF514998
EMBL	AJ487035	http://www.ebi.ac.uk/ena/data/view/AJ487035
EMBL	AY118267	http://www.ebi.ac.uk/ena/data/view/AY118267
EMBL	AY118268	http://www.ebi.ac.uk/ena/data/view/AY118268
Ensembl	ENST00000301365	http://www.ensembl.org/id/ENST00000301365
Ensembl	ENST00000572519	http://www.ensembl.org/id/ENST00000572519
Ensembl	ENST00000576742	http://www.ensembl.org/id/ENST00000576742
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0043235	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043235
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_process	GO:0009408	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408
GO_process	GO:0042636	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042636
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:0090280	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090280
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.25.40.20	http://www.cathdb.info/version/latest/superfamily/1.25.40.20
GeneCards	TRPV3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TRPV3
GeneID	162514	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=162514
GeneTree	ENSGT00550000074425	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074425
H-InvDB	HIX0013427	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0013427
HGNC	HGNC:18084	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18084
HOGENOM	HOG000234630	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234630&db=HOGENOM6
HOVERGEN	HBG054085	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054085&db=HOVERGEN
InParanoid	Q8NET8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8NET8
InterPro	IPR002110	http://www.ebi.ac.uk/interpro/entry/IPR002110
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR008347	http://www.ebi.ac.uk/interpro/entry/IPR008347
InterPro	IPR020683	http://www.ebi.ac.uk/interpro/entry/IPR020683
InterPro	IPR024866	http://www.ebi.ac.uk/interpro/entry/IPR024866
Jabion	162514	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=162514
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:162514	http://www.genome.jp/dbget-bin/www_bget?hsa:162514
KEGG_Orthology	KO:K04972	http://www.genome.jp/dbget-bin/www_bget?KO:K04972
MIM	607066	http://www.ncbi.nlm.nih.gov/omim/607066
MIM	614594	http://www.ncbi.nlm.nih.gov/omim/614594
MIM	616400	http://www.ncbi.nlm.nih.gov/omim/616400
OMA	FVKRMYD	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FVKRMYD
Orphanet	659	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=659
OrthoDB	EOG091G020O	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G020O
PANTHER	PTHR10582:SF6	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10582:SF6
PRINTS	PR01768	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01768
PROSITE	PS50088	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50088
PROSITE	PS50297	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50297
PSORT	swissprot:TRPV3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TRPV3_HUMAN
PSORT-B	swissprot:TRPV3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TRPV3_HUMAN
PSORT2	swissprot:TRPV3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TRPV3_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF12796	http://pfam.xfam.org/family/PF12796
PharmGKB	PA38481	http://www.pharmgkb.org/do/serve?objId=PA38481&objCls=Gene
Phobius	swissprot:TRPV3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TRPV3_HUMAN
PhylomeDB	Q8NET8	http://phylomedb.org/?seqid=Q8NET8
ProteinModelPortal	Q8NET8	http://www.proteinmodelportal.org/query/uniprot/Q8NET8
PubMed	12077604	http://www.ncbi.nlm.nih.gov/pubmed/12077604
PubMed	12077606	http://www.ncbi.nlm.nih.gov/pubmed/12077606
PubMed	21593771	http://www.ncbi.nlm.nih.gov/pubmed/21593771
PubMed	22405088	http://www.ncbi.nlm.nih.gov/pubmed/22405088
PubMed	22835024	http://www.ncbi.nlm.nih.gov/pubmed/22835024
PubMed	25285920	http://www.ncbi.nlm.nih.gov/pubmed/25285920
Reactome	R-HSA-3295583	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3295583
RefSeq	NP_659505	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_659505
SMART	SM00248	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00248
STRING	9606.ENSP00000461518	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000461518&targetmode=cogs
SUPFAM	SSF48403	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48403
TCDB	1.A.4.2	http://www.tcdb.org/search/result.php?tc=1.A.4.2
UCSC	uc002fvr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002fvr&org=rat
UniGene	Hs.446255	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.446255
UniProtKB	TRPV3_HUMAN	http://www.uniprot.org/uniprot/TRPV3_HUMAN
UniProtKB-AC	Q8NET8	http://www.uniprot.org/uniprot/Q8NET8
charge	swissprot:TRPV3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TRPV3_HUMAN
eggNOG	ENOG4110DG4	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110DG4
eggNOG	KOG3676	http://eggnogapi.embl.de/nog_data/html/tree/KOG3676
epestfind	swissprot:TRPV3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TRPV3_HUMAN
garnier	swissprot:TRPV3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TRPV3_HUMAN
helixturnhelix	swissprot:TRPV3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRPV3_HUMAN
hmoment	swissprot:TRPV3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TRPV3_HUMAN
iep	swissprot:TRPV3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TRPV3_HUMAN
inforesidue	swissprot:TRPV3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TRPV3_HUMAN
neXtProt	NX_Q8NET8	http://www.nextprot.org/db/entry/NX_Q8NET8
octanol	swissprot:TRPV3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TRPV3_HUMAN
pepcoil	swissprot:TRPV3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TRPV3_HUMAN
pepdigest	swissprot:TRPV3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TRPV3_HUMAN
pepinfo	swissprot:TRPV3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TRPV3_HUMAN
pepnet	swissprot:TRPV3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TRPV3_HUMAN
pepstats	swissprot:TRPV3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TRPV3_HUMAN
pepwheel	swissprot:TRPV3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TRPV3_HUMAN
pepwindow	swissprot:TRPV3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TRPV3_HUMAN
sigcleave	swissprot:TRPV3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TRPV3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	LAT3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1 {ECO 0000269|PubMed 9722952}; Synonyms=2.3kb {ECO 0000303|PubMed 9722952}; IsoId=O75387-1; Sequence=Displayed; Name=2 {ECO 0000269|PubMed 9722952}; Synonyms=5kb {ECO 0000303|PubMed 9722952}; IsoId=O75387-2; Sequence=VSP_051620; 
# AltName	LAT3_HUMAN	L-type amino acid transporter 3
# AltName	LAT3_HUMAN	Prostate cancer overexpressed gene 1 protein
# AltName	LAT3_HUMAN	Solute carrier family 43 member 1
# BioGrid	114073	3
# CCDS	CCDS7958	-. [O75387-1]
# CDD	cd06174	MFS
# ChiTaRS	SLC43A1	human
# Ensembl	ENST00000278426	ENSP00000278426; ENSG00000149150. [O75387-1]
# Ensembl	ENST00000528450	ENSP00000435673; ENSG00000149150. [O75387-1]
# ExpressionAtlas	O75387	baseline and differential
# FUNCTION	LAT3_HUMAN	Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer. {ECO 0000269|PubMed 11956097, ECO 0000269|PubMed 12930836, ECO 0000269|PubMed 9255310, ECO 0000269|PubMed 9722952}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:UniProtKB.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015175	neutral amino acid transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015179	L-amino acid transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0006865	amino acid transport; TAS:Reactome.
# GO_process	GO:0015804	neutral amino acid transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	O75387	HS
# HGNC	HGNC:9225	SLC43A1
# IntAct	O75387	2
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	603733	gene
# MISCELLANEOUS	LAT3_HUMAN	Up-regulated in early prostate cancer development with highest expression level in seminomas of testicular germ cell tumors. {ECO 0000269|PubMed 11956097, ECO 0000269|PubMed 9255310}. 
# Organism	LAT3_HUMAN	Homo sapiens (Human)
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-352230	Amino acid transport across the plasma membrane
# RecName	LAT3_HUMAN	Large neutral amino acids transporter small subunit 3
# RefSeq	NP_001185739	NM_001198810.1. [O75387-1]
# RefSeq	NP_003618	NM_003627.5. [O75387-1]
# RefSeq	XP_016873940	XM_017018451.1. [O75387-1]
# SIMILARITY	Belongs to the SLC43A transporter (TC 2.A.1.44) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	LAT3_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF103473	SSF103473; 3
# TCDB	2.A.1.44	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	LAT3_HUMAN	In adults, found in all tissues examined with highest expression in pancreas. In fetus, highest expression in liver and lower levels in kidney, and lung. High levels found in prostate cancer cells. {ECO 0000269|PubMed 11956097, ECO 0000269|PubMed 12930836, ECO 0000269|PubMed 9255310, ECO 0000269|PubMed 9722952}. 
# UCSC	uc001nkk	human. [O75387-1]
# eggNOG	ENOG410IHH0	Eukaryota
# eggNOG	ENOG410Y95V	LUCA
BLAST	swissprot:LAT3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:LAT3_HUMAN
BioCyc	ZFISH:ENSG00000149150-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000149150-MONOMER
COXPRESdb	8501	http://coxpresdb.jp/data/gene/8501.shtml
CleanEx	HS_SLC43A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC43A1
DIP	DIP-47272N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47272N
DOI	10.1006/geno.1998.5359	http://dx.doi.org/10.1006/geno.1998.5359
DOI	10.1016/S0090-4295(97)00194-5	http://dx.doi.org/10.1016/S0090-4295(97)00194-5
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1074/jbc.M305221200	http://dx.doi.org/10.1074/jbc.M305221200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB103033	http://www.ebi.ac.uk/ena/data/view/AB103033
EMBL	AF045584	http://www.ebi.ac.uk/ena/data/view/AF045584
EMBL	BC001639	http://www.ebi.ac.uk/ena/data/view/BC001639
Ensembl	ENST00000278426	http://www.ensembl.org/id/ENST00000278426
Ensembl	ENST00000528450	http://www.ensembl.org/id/ENST00000528450
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_function	GO:0015175	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015175
GO_function	GO:0015179	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015179
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GO_process	GO:0015804	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015804
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC43A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC43A1
GeneID	8501	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8501
GeneTree	ENSGT00530000063043	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063043
HGNC	HGNC:9225	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:9225
HOGENOM	HOG000231937	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231937&db=HOGENOM6
HOVERGEN	HBG072879	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG072879&db=HOVERGEN
HPA	HPA018813	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA018813
HPA	HPA018826	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA018826
InParanoid	O75387	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O75387
IntAct	O75387	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O75387*
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	8501	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=8501
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:8501	http://www.genome.jp/dbget-bin/www_bget?hsa:8501
KEGG_Orthology	KO:K08228	http://www.genome.jp/dbget-bin/www_bget?KO:K08228
MIM	603733	http://www.ncbi.nlm.nih.gov/omim/603733
OMA	PRFIRIG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PRFIRIG
OrthoDB	EOG091G0407	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0407
PSORT	swissprot:LAT3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:LAT3_HUMAN
PSORT-B	swissprot:LAT3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:LAT3_HUMAN
PSORT2	swissprot:LAT3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:LAT3_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA33549	http://www.pharmgkb.org/do/serve?objId=PA33549&objCls=Gene
Phobius	swissprot:LAT3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:LAT3_HUMAN
PhylomeDB	O75387	http://phylomedb.org/?seqid=O75387
ProteinModelPortal	O75387	http://www.proteinmodelportal.org/query/uniprot/O75387
PubMed	11956097	http://www.ncbi.nlm.nih.gov/pubmed/11956097
PubMed	12930836	http://www.ncbi.nlm.nih.gov/pubmed/12930836
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	9255310	http://www.ncbi.nlm.nih.gov/pubmed/9255310
PubMed	9722952	http://www.ncbi.nlm.nih.gov/pubmed/9722952
Reactome	R-HSA-352230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-352230
RefSeq	NP_001185739	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001185739
RefSeq	NP_003618	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003618
RefSeq	XP_016873940	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016873940
STRING	9606.ENSP00000278426	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000278426&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.44	http://www.tcdb.org/search/result.php?tc=2.A.1.44
UCSC	uc001nkk	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001nkk&org=rat
UniGene	Hs.591952	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.591952
UniGene	Hs.735724	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.735724
UniProtKB	LAT3_HUMAN	http://www.uniprot.org/uniprot/LAT3_HUMAN
UniProtKB-AC	O75387	http://www.uniprot.org/uniprot/O75387
charge	swissprot:LAT3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:LAT3_HUMAN
eggNOG	ENOG410IHH0	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IHH0
eggNOG	ENOG410Y95V	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y95V
epestfind	swissprot:LAT3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:LAT3_HUMAN
garnier	swissprot:LAT3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:LAT3_HUMAN
helixturnhelix	swissprot:LAT3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:LAT3_HUMAN
hmoment	swissprot:LAT3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:LAT3_HUMAN
iep	swissprot:LAT3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:LAT3_HUMAN
inforesidue	swissprot:LAT3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:LAT3_HUMAN
neXtProt	NX_O75387	http://www.nextprot.org/db/entry/NX_O75387
octanol	swissprot:LAT3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:LAT3_HUMAN
pepcoil	swissprot:LAT3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:LAT3_HUMAN
pepdigest	swissprot:LAT3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:LAT3_HUMAN
pepinfo	swissprot:LAT3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:LAT3_HUMAN
pepnet	swissprot:LAT3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:LAT3_HUMAN
pepstats	swissprot:LAT3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:LAT3_HUMAN
pepwheel	swissprot:LAT3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:LAT3_HUMAN
pepwindow	swissprot:LAT3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:LAT3_HUMAN
sigcleave	swissprot:LAT3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:LAT3_HUMAN
## Database	ID	URL or Descriptions
# AltName	VATG1_HUMAN	V-ATPase 13 kDa subunit 1
# AltName	VATG1_HUMAN	Vacuolar proton pump subunit G 1
# AltName	VATG1_HUMAN	Vacuolar proton pump subunit M16
# BioGrid	114922	26
# ChiTaRS	ATP6V1G1	human
# Ensembl	ENST00000374050	ENSP00000363162; ENSG00000136888
# ExpressionAtlas	O75348	baseline and differential
# FUNCTION	VATG1_HUMAN	Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. 
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005829	cytosol; ISS:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016471	vacuolar proton-transporting V-type ATPase complex; IEA:Ensembl.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism; IEA:Ensembl.
# GO_function	GO:0051117	ATPase binding; IPI:UniProtKB.
# GO_process	GO:0008286	insulin receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0016241	regulation of macroautophagy; NAS:ParkinsonsUK-UCL.
# GO_process	GO:0033572	transferrin transport; TAS:Reactome.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0090383	phagosome acidification; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	O75348	HS
# HGNC	HGNC:864	ATP6V1G1
# INTERACTION	VATG1_HUMAN	Q96A05 ATP6V1E2; NbExp=6; IntAct=EBI-711802, EBI-8650380; Q08379 GOLGA2; NbExp=3; IntAct=EBI-711802, EBI-618309; O95751 LDOC1; NbExp=3; IntAct=EBI-711802, EBI-740738; P43360 MAGEA6; NbExp=3; IntAct=EBI-711802, EBI-1045155; 
# IntAct	O75348	37
# InterPro	IPR005124	V-ATPase_G
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04966	Collecting duct acid secretion
# KEGG_Pathway	ko05110	Vibrio cholerae infection
# KEGG_Pathway	ko05120	Epithelial cell signaling in Helicobacter pylori infection
# KEGG_Pathway	ko05323	Rheumatoid arthritis
# MIM	607296	gene
# Organism	VATG1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12713	PTHR12713
# Proteomes	UP000005640	Chromosome 9
# Reactome	R-HSA-1222556	ROS, RNS production in response to bacteria
# Reactome	R-HSA-77387	Insulin receptor recycling
# Reactome	R-HSA-917977	Transferrin endocytosis and recycling
# Reactome	R-HSA-983712	Ion channel transport
# RecName	VATG1_HUMAN	V-type proton ATPase subunit G 1
# RefSeq	NP_004879	NM_004888.3
# SIMILARITY	Belongs to the V-ATPase G subunit family. {ECO	0000305}.
# SUBUNIT	V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components	 a, c, c', c'' and d). 
# TCDB	3.A.2.2	the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily
# TIGRFAMs	TIGR01147	V_ATP_synt_G
# TISSUE SPECIFICITY	Ubiquitous. {ECO:0000269|PubMed	12384298}. 
# UCSC	uc004bjc	human
# eggNOG	ENOG4111XX0	LUCA
# eggNOG	KOG1772	Eukaryota
BLAST	swissprot:VATG1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VATG1_HUMAN
BioCyc	MetaCyc:HS06241-MONOMER	http://biocyc.org/getid?id=MetaCyc:HS06241-MONOMER
BioCyc	ZFISH:HS06241-MONOMER	http://biocyc.org/getid?id=ZFISH:HS06241-MONOMER
COXPRESdb	9550	http://coxpresdb.jp/data/gene/9550.shtml
CleanEx	HS_ATP6V1G1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP6V1G1
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/S0378-1119(02)00884-3	http://dx.doi.org/10.1016/S0378-1119(02)00884-3
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
DOI	10.1073/pnas.95.14.8175	http://dx.doi.org/10.1073/pnas.95.14.8175
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF038954	http://www.ebi.ac.uk/ena/data/view/AF038954
EMBL	AL160275	http://www.ebi.ac.uk/ena/data/view/AL160275
EMBL	BC008452	http://www.ebi.ac.uk/ena/data/view/BC008452
EMBL	CH471090	http://www.ebi.ac.uk/ena/data/view/CH471090
EMBL	CR456971	http://www.ebi.ac.uk/ena/data/view/CR456971
EMBL	CR542237	http://www.ebi.ac.uk/ena/data/view/CR542237
Ensembl	ENST00000374050	http://www.ensembl.org/id/ENST00000374050
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016471
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0008553	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008553
GO_function	GO:0051117	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051117
GO_process	GO:0008286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008286
GO_process	GO:0016241	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016241
GO_process	GO:0033572	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033572
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0090383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090383
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ATP6V1G1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP6V1G1
GeneID	9550	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9550
GeneTree	ENSGT00390000011172	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000011172
HGNC	HGNC:864	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:864
HOGENOM	HOG000186416	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000186416&db=HOGENOM6
HOVERGEN	HBG057827	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG057827&db=HOVERGEN
HPA	CAB004615	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB004615
HPA	HPA042898	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042898
InParanoid	O75348	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O75348
IntAct	O75348	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O75348*
InterPro	IPR005124	http://www.ebi.ac.uk/interpro/entry/IPR005124
Jabion	9550	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9550
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:9550	http://www.genome.jp/dbget-bin/www_bget?hsa:9550
KEGG_Orthology	KO:K02152	http://www.genome.jp/dbget-bin/www_bget?KO:K02152
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04966	http://www.genome.jp/kegg-bin/show_pathway?ko04966
KEGG_Pathway	ko05110	http://www.genome.jp/kegg-bin/show_pathway?ko05110
KEGG_Pathway	ko05120	http://www.genome.jp/kegg-bin/show_pathway?ko05120
KEGG_Pathway	ko05323	http://www.genome.jp/kegg-bin/show_pathway?ko05323
MIM	607296	http://www.ncbi.nlm.nih.gov/omim/607296
MINT	MINT-5001706	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5001706
OMA	QPEFHAN	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QPEFHAN
OrthoDB	EOG091G0XIZ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0XIZ
PANTHER	PTHR12713	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12713
PSORT	swissprot:VATG1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VATG1_HUMAN
PSORT-B	swissprot:VATG1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VATG1_HUMAN
PSORT2	swissprot:VATG1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VATG1_HUMAN
PharmGKB	PA25163	http://www.pharmgkb.org/do/serve?objId=PA25163&objCls=Gene
Phobius	swissprot:VATG1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VATG1_HUMAN
PhylomeDB	O75348	http://phylomedb.org/?seqid=O75348
ProteinModelPortal	O75348	http://www.proteinmodelportal.org/query/uniprot/O75348
PubMed	12384298	http://www.ncbi.nlm.nih.gov/pubmed/12384298
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	9653160	http://www.ncbi.nlm.nih.gov/pubmed/9653160
Reactome	R-HSA-1222556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1222556
Reactome	R-HSA-77387	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-77387
Reactome	R-HSA-917977	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917977
Reactome	R-HSA-983712	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983712
RefSeq	NP_004879	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004879
SMR	O75348	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O75348
STRING	9606.ENSP00000363162	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000363162&targetmode=cogs
TCDB	3.A.2.2	http://www.tcdb.org/search/result.php?tc=3.A.2.2
TIGRFAMs	TIGR01147	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01147
UCSC	uc004bjc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004bjc&org=rat
UniGene	Hs.388654	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.388654
UniProtKB	VATG1_HUMAN	http://www.uniprot.org/uniprot/VATG1_HUMAN
UniProtKB-AC	O75348	http://www.uniprot.org/uniprot/O75348
charge	swissprot:VATG1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VATG1_HUMAN
eggNOG	ENOG4111XX0	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111XX0
eggNOG	KOG1772	http://eggnogapi.embl.de/nog_data/html/tree/KOG1772
epestfind	swissprot:VATG1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VATG1_HUMAN
garnier	swissprot:VATG1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VATG1_HUMAN
helixturnhelix	swissprot:VATG1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VATG1_HUMAN
hmoment	swissprot:VATG1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VATG1_HUMAN
iep	swissprot:VATG1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VATG1_HUMAN
inforesidue	swissprot:VATG1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VATG1_HUMAN
neXtProt	NX_O75348	http://www.nextprot.org/db/entry/NX_O75348
octanol	swissprot:VATG1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VATG1_HUMAN
pepcoil	swissprot:VATG1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VATG1_HUMAN
pepdigest	swissprot:VATG1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VATG1_HUMAN
pepinfo	swissprot:VATG1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VATG1_HUMAN
pepnet	swissprot:VATG1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VATG1_HUMAN
pepstats	swissprot:VATG1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VATG1_HUMAN
pepwheel	swissprot:VATG1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VATG1_HUMAN
pepwindow	swissprot:VATG1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VATG1_HUMAN
sigcleave	swissprot:VATG1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VATG1_HUMAN
## Database	ID	URL or Descriptions
# AltName	GPHRB_HUMAN	Protein GPR89B
# BioGrid	119554	16
# BioGrid	575849	36
# Ensembl	ENST00000314163	ENSP00000358233; ENSG00000188092
# ExpressionAtlas	P0CG08	baseline and differential
# FUNCTION	GPHRB_HUMAN	Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance. {ECO 0000250, ECO 0000269|PubMed 18794847}. 
# GO_component	GO:0000139	Golgi membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005244	voltage-gated ion channel activity; IEA:UniProtKB-KW.
# GO_process	GO:0015031	protein transport; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	P0CG08	HS
# HGNC	HGNC:13840	GPR89B
# InterPro	IPR015672	GPHR/GTG
# InterPro	IPR022535	Golgi_pH-regulator_cons_dom
# InterPro	IPR025969	ABA_GPCR_dom
# MIM	612806	gene
# MISCELLANEOUS	GPHRB_HUMAN	Does not seem to be able to bind GTP. 
# Organism	GPHRB_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR15948	PTHR15948
# Pfam	PF12430	ABA_GPCR
# Pfam	PF12537	GPHR_N
# Proteomes	UP000005640	Chromosome 1
# RecName	GPHRB_HUMAN	Golgi pH regulator B
# RefSeq	NP_001091081	NM_001097612.1
# RefSeq	NP_057418	NM_016334.3
# RefSeq	XP_005277458	XM_005277401.3
# RefSeq	XP_006711555	XM_006711492.3
# RefSeq	XP_011507915	XM_011509613.2
# RefSeq	XP_011508212	XM_011509910.2
# SEQUENCE CAUTION	Sequence=AAF36121.1; Type=Erroneous termination; Positions=297; Note=Translated as Cys.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the Golgi pH regulator (TC 1.A.38) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	GPHRB_HUMAN	Golgi apparatus membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUBUNIT	Homotrimer. {ECO	0000250}. 
# TISSUE SPECIFICITY	Ubiquitous. {ECO:0000269|PubMed	18794847}. 
# eggNOG	ENOG410XQ8R	LUCA
# eggNOG	KOG2417	Eukaryota
BLAST	swissprot:GPHRB_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GPHRB_HUMAN
BioCyc	ZFISH:G66-32328-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32328-MONOMER
BioCyc	ZFISH:G66-32998-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32998-MONOMER
COXPRESdb	51463	http://coxpresdb.jp/data/gene/51463.shtml
COXPRESdb	653519	http://coxpresdb.jp/data/gene/653519.shtml
DOI	10.1016/j.cell.2008.12.026	http://dx.doi.org/10.1016/j.cell.2008.12.026
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ncb1773	http://dx.doi.org/10.1038/ncb1773
DOI	10.1101/gr.140200	http://dx.doi.org/10.1101/gr.140200
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AF151035	http://www.ebi.ac.uk/ena/data/view/AF151035
EMBL	AL133020	http://www.ebi.ac.uk/ena/data/view/AL133020
EMBL	AL356004	http://www.ebi.ac.uk/ena/data/view/AL356004
EMBL	AL445591	http://www.ebi.ac.uk/ena/data/view/AL445591
EMBL	AL445591	http://www.ebi.ac.uk/ena/data/view/AL445591
EMBL	BX537254	http://www.ebi.ac.uk/ena/data/view/BX537254
EMBL	BX537254	http://www.ebi.ac.uk/ena/data/view/BX537254
EMBL	U78723	http://www.ebi.ac.uk/ena/data/view/U78723
Ensembl	ENST00000314163	http://www.ensembl.org/id/ENST00000314163
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005244
GO_process	GO:0015031	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	GPR89B	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GPR89B
GeneID	51463	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51463
GeneID	653519	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=653519
GeneTree	ENSGT00390000000684	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000000684
H-InvDB	HIX0000982	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0000982
H-InvDB	HIX0056760	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0056760
H-InvDB	HIX0159660	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0159660
HGNC	HGNC:13840	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13840
HOGENOM	HOG000240999	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000240999&db=HOGENOM6
HOVERGEN	HBG054909	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054909&db=HOVERGEN
InParanoid	P0CG08	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CG08
InterPro	IPR015672	http://www.ebi.ac.uk/interpro/entry/IPR015672
InterPro	IPR022535	http://www.ebi.ac.uk/interpro/entry/IPR022535
InterPro	IPR025969	http://www.ebi.ac.uk/interpro/entry/IPR025969
Jabion	51463	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=51463
Jabion	653519	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=653519
KEGG_Gene	hsa:51463	http://www.genome.jp/dbget-bin/www_bget?hsa:51463
KEGG_Gene	hsa:653519	http://www.genome.jp/dbget-bin/www_bget?hsa:653519
MIM	612806	http://www.ncbi.nlm.nih.gov/omim/612806
OrthoDB	EOG091G06HP	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G06HP
PANTHER	PTHR15948	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15948
PSORT	swissprot:GPHRB_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GPHRB_HUMAN
PSORT-B	swissprot:GPHRB_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GPHRB_HUMAN
PSORT2	swissprot:GPHRB_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GPHRB_HUMAN
Pfam	PF12430	http://pfam.xfam.org/family/PF12430
Pfam	PF12537	http://pfam.xfam.org/family/PF12537
PharmGKB	PA134986137	http://www.pharmgkb.org/do/serve?objId=PA134986137&objCls=Gene
PharmGKB	PA143485481	http://www.pharmgkb.org/do/serve?objId=PA143485481&objCls=Gene
Phobius	swissprot:GPHRB_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GPHRB_HUMAN
PhylomeDB	P0CG08	http://phylomedb.org/?seqid=P0CG08
ProteinModelPortal	P0CG08	http://www.proteinmodelportal.org/query/uniprot/P0CG08
PubMed	11042152	http://www.ncbi.nlm.nih.gov/pubmed/11042152
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18794847	http://www.ncbi.nlm.nih.gov/pubmed/18794847
PubMed	19135895	http://www.ncbi.nlm.nih.gov/pubmed/19135895
RefSeq	NP_001091081	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001091081
RefSeq	NP_057418	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_057418
RefSeq	XP_005277458	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005277458
RefSeq	XP_006711555	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006711555
RefSeq	XP_011507915	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011507915
RefSeq	XP_011508212	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011508212
STRING	9606.ENSP00000358233	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000358233&targetmode=cogs
UniGene	Hs.504320	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.504320
UniGene	Hs.559115	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.559115
UniGene	Hs.645432	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.645432
UniGene	Hs.680770	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.680770
UniProtKB	GPHRB_HUMAN	http://www.uniprot.org/uniprot/GPHRB_HUMAN
UniProtKB-AC	P0CG08	http://www.uniprot.org/uniprot/P0CG08
charge	swissprot:GPHRB_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GPHRB_HUMAN
eggNOG	ENOG410XQ8R	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ8R
eggNOG	KOG2417	http://eggnogapi.embl.de/nog_data/html/tree/KOG2417
epestfind	swissprot:GPHRB_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GPHRB_HUMAN
garnier	swissprot:GPHRB_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GPHRB_HUMAN
helixturnhelix	swissprot:GPHRB_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GPHRB_HUMAN
hmoment	swissprot:GPHRB_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GPHRB_HUMAN
iep	swissprot:GPHRB_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GPHRB_HUMAN
inforesidue	swissprot:GPHRB_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GPHRB_HUMAN
neXtProt	NX_P0CG08	http://www.nextprot.org/db/entry/NX_P0CG08
octanol	swissprot:GPHRB_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GPHRB_HUMAN
pepcoil	swissprot:GPHRB_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GPHRB_HUMAN
pepdigest	swissprot:GPHRB_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GPHRB_HUMAN
pepinfo	swissprot:GPHRB_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GPHRB_HUMAN
pepnet	swissprot:GPHRB_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GPHRB_HUMAN
pepstats	swissprot:GPHRB_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GPHRB_HUMAN
pepwheel	swissprot:GPHRB_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GPHRB_HUMAN
pepwindow	swissprot:GPHRB_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GPHRB_HUMAN
sigcleave	swissprot:GPHRB_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GPHRB_HUMAN
## Database	ID	URL or Descriptions
# AltName	CSC1_HUMAN	Transmembrane protein 63C
# ENZYME REGULATION	Activated by hyperosmotic shock after mannitol treatment. {ECO:0000269|PubMed	24503647}. 
# Ensembl	ENST00000298351	ENSP00000298351; ENSG00000165548
# ExpressionAtlas	Q9P1W3	baseline and differential
# FUNCTION	CSC1_HUMAN	Acts as an osmosensitive calcium-permeable cation channel. {ECO 0000269|PubMed 24503647}. 
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005227	calcium activated cation channel activity; IDA:UniProtKB.
# GO_process	GO:0006812	cation transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q9P1W3	HS
# HGNC	HGNC:23787	TMEM63C
# InterPro	IPR003864	RSN1_7TM
# InterPro	IPR027815	PHM7_cyt
# InterPro	IPR032880	Csc1_N
# Organism	CSC1_HUMAN	Homo sapiens (Human)
# PIR	T46920	T46920
# Pfam	PF02714	RSN1_7TM
# Pfam	PF13967	RSN1_TM
# Pfam	PF14703	PHM7_cyt
# Proteomes	UP000005640	Chromosome 14
# RecName	CSC1_HUMAN	Calcium permeable stress-gated cation channel 1
# RefSeq	NP_065164	NM_020431.3
# SEQUENCE CAUTION	Sequence=AAF62556.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the CSC1 (TC 1.A.17) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	CSC1_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	1.A.17.5.12	the calcium-dependent chloride channel (ca-clc) family
# UCSC	uc001xtf	human
# eggNOG	COG5594	LUCA
# eggNOG	KOG1134	Eukaryota
BLAST	swissprot:CSC1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CSC1_HUMAN
COXPRESdb	57156	http://coxpresdb.jp/data/gene/57156.shtml
CleanEx	HS_TMEM63C	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TMEM63C
DOI	10.1038/cr.2014.14	http://dx.doi.org/10.1038/cr.2014.14
DOI	10.1038/nature01348	http://dx.doi.org/10.1038/nature01348
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AC007375	http://www.ebi.ac.uk/ena/data/view/AC007375
EMBL	AC007954	http://www.ebi.ac.uk/ena/data/view/AC007954
EMBL	AK125159	http://www.ebi.ac.uk/ena/data/view/AK125159
EMBL	AL157492	http://www.ebi.ac.uk/ena/data/view/AL157492
EMBL	BC136613	http://www.ebi.ac.uk/ena/data/view/BC136613
EMBL	BC136614	http://www.ebi.ac.uk/ena/data/view/BC136614
EMBL	BX248756	http://www.ebi.ac.uk/ena/data/view/BX248756
EMBL	BX248759	http://www.ebi.ac.uk/ena/data/view/BX248759
EMBL	CH471061	http://www.ebi.ac.uk/ena/data/view/CH471061
Ensembl	ENST00000298351	http://www.ensembl.org/id/ENST00000298351
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005227	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005227
GO_process	GO:0006812	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006812
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	TMEM63C	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TMEM63C
GeneID	57156	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57156
GeneTree	ENSGT00390000011855	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000011855
H-InvDB	HIX0011843	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0011843
HGNC	HGNC:23787	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:23787
HOGENOM	HOG000006559	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006559&db=HOGENOM6
HOVERGEN	HBG056752	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG056752&db=HOVERGEN
HPA	HPA030657	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA030657
InParanoid	Q9P1W3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9P1W3
InterPro	IPR003864	http://www.ebi.ac.uk/interpro/entry/IPR003864
InterPro	IPR027815	http://www.ebi.ac.uk/interpro/entry/IPR027815
InterPro	IPR032880	http://www.ebi.ac.uk/interpro/entry/IPR032880
Jabion	57156	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=57156
KEGG_Gene	hsa:57156	http://www.genome.jp/dbget-bin/www_bget?hsa:57156
OMA	SFFYFIT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SFFYFIT
OrthoDB	EOG091G02SZ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02SZ
PSORT	swissprot:CSC1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CSC1_HUMAN
PSORT-B	swissprot:CSC1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CSC1_HUMAN
PSORT2	swissprot:CSC1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CSC1_HUMAN
Pfam	PF02714	http://pfam.xfam.org/family/PF02714
Pfam	PF13967	http://pfam.xfam.org/family/PF13967
Pfam	PF14703	http://pfam.xfam.org/family/PF14703
PharmGKB	PA134993950	http://www.pharmgkb.org/do/serve?objId=PA134993950&objCls=Gene
Phobius	swissprot:CSC1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CSC1_HUMAN
PhylomeDB	Q9P1W3	http://phylomedb.org/?seqid=Q9P1W3
ProteinModelPortal	Q9P1W3	http://www.proteinmodelportal.org/query/uniprot/Q9P1W3
PubMed	12508121	http://www.ncbi.nlm.nih.gov/pubmed/12508121
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	24503647	http://www.ncbi.nlm.nih.gov/pubmed/24503647
RefSeq	NP_065164	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_065164
STRING	9606.ENSP00000298351	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000298351&targetmode=cogs
TCDB	1.A.17.5.12	http://www.tcdb.org/search/result.php?tc=1.A.17.5.12
UCSC	uc001xtf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001xtf&org=rat
UniGene	Hs.22452	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.22452
UniProtKB	CSC1_HUMAN	http://www.uniprot.org/uniprot/CSC1_HUMAN
UniProtKB-AC	Q9P1W3	http://www.uniprot.org/uniprot/Q9P1W3
charge	swissprot:CSC1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CSC1_HUMAN
eggNOG	COG5594	http://eggnogapi.embl.de/nog_data/html/tree/COG5594
eggNOG	KOG1134	http://eggnogapi.embl.de/nog_data/html/tree/KOG1134
epestfind	swissprot:CSC1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CSC1_HUMAN
garnier	swissprot:CSC1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CSC1_HUMAN
helixturnhelix	swissprot:CSC1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CSC1_HUMAN
hmoment	swissprot:CSC1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CSC1_HUMAN
iep	swissprot:CSC1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CSC1_HUMAN
inforesidue	swissprot:CSC1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CSC1_HUMAN
neXtProt	NX_Q9P1W3	http://www.nextprot.org/db/entry/NX_Q9P1W3
octanol	swissprot:CSC1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CSC1_HUMAN
pepcoil	swissprot:CSC1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CSC1_HUMAN
pepdigest	swissprot:CSC1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CSC1_HUMAN
pepinfo	swissprot:CSC1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CSC1_HUMAN
pepnet	swissprot:CSC1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CSC1_HUMAN
pepstats	swissprot:CSC1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CSC1_HUMAN
pepwheel	swissprot:CSC1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CSC1_HUMAN
pepwindow	swissprot:CSC1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CSC1_HUMAN
sigcleave	swissprot:CSC1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CSC1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CYB5_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Liver, Membrane-bound; IsoId=P00167-1; Sequence=Displayed; Name=2; Synonyms=Erythrocyte, Cytoplasmic; IsoId=P00167-2; Sequence=VSP_001240, VSP_001241; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; IsoId=P00167-3; Sequence=VSP_045367; Note=No experimental confirmation available.; 
# AltName	CYB5_HUMAN	Microsomal cytochrome b5 type A
# BioGrid	107908	23
# CCDS	CCDS12004	-. [P00167-1]
# CCDS	CCDS12005	-. [P00167-2]
# CCDS	CCDS54188	-. [P00167-3]
# ChiTaRS	CYB5A	human
# DISEASE	CYB5_HUMAN	Methemoglobinemia CYB5A-related (METHB-CYB5A) [MIM 250790]  A form of methemoglobinemia, a hematologic disease characterized by the presence of excessive amounts of methemoglobin in blood cells, resulting in decreased oxygen carrying capacity of the blood, cyanosis and hypoxia. {ECO 0000269|PubMed 8168836}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000340533	ENSP00000341625; ENSG00000166347. [P00167-1]
# Ensembl	ENST00000397914	ENSP00000381011; ENSG00000166347. [P00167-3]
# Ensembl	ENST00000494131	ENSP00000436461; ENSG00000166347. [P00167-2]
# ExpressionAtlas	P00167	baseline and differential
# FUNCTION	CYB5_HUMAN	Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases. 
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0005741	mitochondrial outer membrane; TAS:Reactome.
# GO_component	GO:0005789	endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0004033	aldo-keto reductase (NADP) activity; TAS:Reactome.
# GO_function	GO:0004129	cytochrome-c oxidase activity; TAS:ProtInc.
# GO_function	GO:0019899	enzyme binding; IPI:BHF-UCL.
# GO_function	GO:0020037	heme binding; IEA:InterPro.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0019852	L-ascorbic acid metabolic process; TAS:Reactome.
# GO_process	GO:0046686	response to cadmium ion; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0005975	carbohydrate metabolic process
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0044281	small molecule metabolic process
# Gene3D	3.10.120.10	-; 1.
# Genevisible	P00167	HS
# HGNC	HGNC:2570	CYB5A
# IntAct	P00167	4
# InterPro	IPR001199	Cyt_B5-like_heme/steroid-bd
# InterPro	IPR018506	Cyt_B5_heme-BS
# KEGG_Disease	H00235	[Hematologic disease] Methemoglobinemia
# MIM	250790	phenotype
# MIM	613218	gene
# Organism	CYB5_HUMAN	Homo sapiens (Human)
# Orphanet	90796	46,XY disorder of sex development due to isolated 17,20 lyase deficiency
# PDB	2I96	NMR; -; A=1-108
# PIR	A28936	CBHU5
# PIR	JN0075	CBHU5E
# PRINTS	PR00363	CYTOCHROMEB5
# PROSITE	PS00191	CYTOCHROME_B5_1
# PROSITE	PS50255	CYTOCHROME_B5_2
# Pfam	PF00173	Cyt-b5
# Proteomes	UP000005640	Chromosome 18
# Reactome	R-HSA-196836	Vitamin C (ascorbate) metabolism
# RecName	CYB5_HUMAN	Cytochrome b5
# RefSeq	NP_001177736	NM_001190807.2. [P00167-3]
# RefSeq	NP_001905	NM_001914.3. [P00167-2]
# RefSeq	NP_683725	NM_148923.3. [P00167-1]
# RefSeq	XP_011524137	XM_011525835.2. [P00167-2]
# SEQUENCE CAUTION	Sequence=AAA63169.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the cytochrome b5 family. {ECO	0000305}. 
# SIMILARITY	Contains 1 cytochrome b5 heme-binding domain. {ECO:0000255|PROSITE-ProRule	PRU00279}. 
# SMART	SM01117	Cyt-b5
# SUBCELLULAR LOCATION	CYB5_HUMAN	Isoform 1  Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side. Microsome membrane; Single-pass membrane protein; Cytoplasmic side. 
# SUBCELLULAR LOCATION	CYB5_HUMAN	Isoform 2  Cytoplasm. 
# SUPFAM	SSF55856	SSF55856
# TopDownProteomics	P00167-1	-. [P00167-1]
# TopDownProteomics	P00167-3	-. [P00167-3]
# UCSC	uc002llh	human. [P00167-1]
# eggNOG	COG5274	LUCA
# eggNOG	KOG0537	Eukaryota
BLAST	swissprot:CYB5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CYB5_HUMAN
BioCyc	MetaCyc:ENSG00000166347-MONOMER	http://biocyc.org/getid?id=MetaCyc:ENSG00000166347-MONOMER
BioCyc	ZFISH:ENSG00000166347-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000166347-MONOMER
COXPRESdb	1528	http://coxpresdb.jp/data/gene/1528.shtml
CleanEx	HS_CYB5A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CYB5A
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/bbrc.1995.1582	http://dx.doi.org/10.1006/bbrc.1995.1582
DOI	10.1007/BF00202825	http://dx.doi.org/10.1007/BF00202825
DOI	10.1016/0006-291X(91)91776-9	http://dx.doi.org/10.1016/0006-291X(91)91776-9
DOI	10.1016/0167-4838(89)90143-X	http://dx.doi.org/10.1016/0167-4838(89)90143-X
DOI	10.1016/S0006-291X(88)80881-7	http://dx.doi.org/10.1016/S0006-291X(88)80881-7
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature03983	http://dx.doi.org/10.1038/nature03983
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AC090398	http://www.ebi.ac.uk/ena/data/view/AC090398
EMBL	BC015182	http://www.ebi.ac.uk/ena/data/view/BC015182
EMBL	CA771478	http://www.ebi.ac.uk/ena/data/view/CA771478
EMBL	CH471117	http://www.ebi.ac.uk/ena/data/view/CH471117
EMBL	CR456990	http://www.ebi.ac.uk/ena/data/view/CR456990
EMBL	L39792	http://www.ebi.ac.uk/ena/data/view/L39792
EMBL	L39941	http://www.ebi.ac.uk/ena/data/view/L39941
EMBL	L39942	http://www.ebi.ac.uk/ena/data/view/L39942
EMBL	L39943	http://www.ebi.ac.uk/ena/data/view/L39943
EMBL	L39944	http://www.ebi.ac.uk/ena/data/view/L39944
EMBL	L39945	http://www.ebi.ac.uk/ena/data/view/L39945
EMBL	M22865	http://www.ebi.ac.uk/ena/data/view/M22865
EMBL	M60174	http://www.ebi.ac.uk/ena/data/view/M60174
Ensembl	ENST00000340533	http://www.ensembl.org/id/ENST00000340533
Ensembl	ENST00000397914	http://www.ensembl.org/id/ENST00000397914
Ensembl	ENST00000494131	http://www.ensembl.org/id/ENST00000494131
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005741	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005741
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0004033	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004033
GO_function	GO:0004129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004129
GO_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GO_function	GO:0020037	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0019852	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019852
GO_process	GO:0046686	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046686
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
Gene3D	3.10.120.10	http://www.cathdb.info/version/latest/superfamily/3.10.120.10
GeneCards	CYB5A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CYB5A
GeneID	1528	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1528
GeneTree	ENSGT00510000046507	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00510000046507
HGNC	HGNC:2570	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2570
HOGENOM	HOG000039853	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000039853&db=HOGENOM6
HOVERGEN	HBG002653	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG002653&db=HOVERGEN
HPA	CAB006333	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB006333
HPA	HPA047548	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA047548
HPA	HPA058547	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA058547
InParanoid	P00167	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00167
IntAct	P00167	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00167*
InterPro	IPR001199	http://www.ebi.ac.uk/interpro/entry/IPR001199
InterPro	IPR018506	http://www.ebi.ac.uk/interpro/entry/IPR018506
Jabion	1528	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1528
KEGG_Disease	H00235	http://www.genome.jp/dbget-bin/www_bget?H00235
KEGG_Gene	hsa:1528	http://www.genome.jp/dbget-bin/www_bget?hsa:1528
MIM	250790	http://www.ncbi.nlm.nih.gov/omim/250790
MIM	613218	http://www.ncbi.nlm.nih.gov/omim/613218
MINT	MINT-3003425	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3003425
OMA	FKSTWII	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FKSTWII
Orphanet	90796	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=90796
OrthoDB	EOG091G17G8	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G17G8
PDB	2I96	http://www.ebi.ac.uk/pdbe-srv/view/entry/2I96
PDBsum	2I96	http://www.ebi.ac.uk/pdbsum/2I96
PRINTS	PR00363	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00363
PROSITE	PS00191	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00191
PROSITE	PS50255	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50255
PSORT	swissprot:CYB5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CYB5_HUMAN
PSORT-B	swissprot:CYB5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CYB5_HUMAN
PSORT2	swissprot:CYB5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CYB5_HUMAN
Pfam	PF00173	http://pfam.xfam.org/family/PF00173
PharmGKB	PA27068	http://www.pharmgkb.org/do/serve?objId=PA27068&objCls=Gene
Phobius	swissprot:CYB5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CYB5_HUMAN
PhylomeDB	P00167	http://phylomedb.org/?seqid=P00167
ProteinModelPortal	P00167	http://www.proteinmodelportal.org/query/uniprot/P00167
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16177791	http://www.ncbi.nlm.nih.gov/pubmed/16177791
PubMed	1712589	http://www.ncbi.nlm.nih.gov/pubmed/1712589
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	2752049	http://www.ncbi.nlm.nih.gov/pubmed/2752049
PubMed	3178851	http://www.ncbi.nlm.nih.gov/pubmed/3178851
PubMed	4030743	http://www.ncbi.nlm.nih.gov/pubmed/4030743
PubMed	4770377	http://www.ncbi.nlm.nih.gov/pubmed/4770377
PubMed	4993957	http://www.ncbi.nlm.nih.gov/pubmed/4993957
PubMed	5062820	http://www.ncbi.nlm.nih.gov/pubmed/5062820
PubMed	7733981	http://www.ncbi.nlm.nih.gov/pubmed/7733981
PubMed	8168836	http://www.ncbi.nlm.nih.gov/pubmed/8168836
Reactome	R-HSA-196836	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-196836
RefSeq	NP_001177736	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001177736
RefSeq	NP_001905	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001905
RefSeq	NP_683725	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_683725
RefSeq	XP_011524137	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011524137
SMART	SM01117	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01117
SMR	P00167	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00167
STRING	9606.ENSP00000341625	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000341625&targetmode=cogs
SUPFAM	SSF55856	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55856
UCSC	uc002llh	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002llh&org=rat
UniGene	Hs.465413	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.465413
UniProtKB	CYB5_HUMAN	http://www.uniprot.org/uniprot/CYB5_HUMAN
UniProtKB-AC	P00167	http://www.uniprot.org/uniprot/P00167
charge	swissprot:CYB5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CYB5_HUMAN
eggNOG	COG5274	http://eggnogapi.embl.de/nog_data/html/tree/COG5274
eggNOG	KOG0537	http://eggnogapi.embl.de/nog_data/html/tree/KOG0537
epestfind	swissprot:CYB5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CYB5_HUMAN
garnier	swissprot:CYB5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CYB5_HUMAN
helixturnhelix	swissprot:CYB5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYB5_HUMAN
hmoment	swissprot:CYB5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CYB5_HUMAN
iep	swissprot:CYB5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CYB5_HUMAN
inforesidue	swissprot:CYB5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CYB5_HUMAN
neXtProt	NX_P00167	http://www.nextprot.org/db/entry/NX_P00167
octanol	swissprot:CYB5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CYB5_HUMAN
pepcoil	swissprot:CYB5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CYB5_HUMAN
pepdigest	swissprot:CYB5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CYB5_HUMAN
pepinfo	swissprot:CYB5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CYB5_HUMAN
pepnet	swissprot:CYB5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CYB5_HUMAN
pepstats	swissprot:CYB5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CYB5_HUMAN
pepwheel	swissprot:CYB5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CYB5_HUMAN
pepwindow	swissprot:CYB5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CYB5_HUMAN
sigcleave	swissprot:CYB5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CYB5_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ABCC8_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q09428-1; Sequence=Displayed; Name=2; IsoId=Q09428-2; Sequence=VSP_000055; Name=3; Synonyms=SUR1Delta2; IsoId=Q09428-3; Sequence=VSP_044090; Note=Abundant isoform with prodiabetic properties, predominant in heart.; 
# AltName	ABCC8_HUMAN	Sulfonylurea receptor 1
# BioGrid	112700	2
# CCDS	CCDS31437	-. [Q09428-1]
# CCDS	CCDS73264	-. [Q09428-2]
# ChiTaRS	ABCC8	human
# DISEASE	ABCC8_HUMAN	Diabetes mellitus, permanent neonatal (PNDM) [MIM 606176]  A rare form of diabetes distinct from childhood- onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy. {ECO 0000269|PubMed 16613899, ECO 0000269|PubMed 16885549, ECO 0000269|PubMed 17213273, ECO 0000269|PubMed 17668386}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ABCC8_HUMAN	Familial hyperinsulinemic hypoglycemia 1 (HHF1) [MIM 256450]  Most common cause of persistent hypoglycemia in infancy. Unless early and aggressive intervention is undertaken, brain damage from recurrent episodes of hypoglycemia may occur. {ECO 0000269|PubMed 10202168, ECO 0000269|PubMed 10334322, ECO 0000269|PubMed 12364426, ECO 0000269|PubMed 12941782, ECO 0000269|PubMed 15562009, ECO 0000269|PubMed 15579781, ECO 0000269|PubMed 15807877, ECO 0000269|PubMed 16357843, ECO 0000269|PubMed 16429405, ECO 0000269|PubMed 24814349, ECO 0000269|PubMed 25720052, ECO 0000269|PubMed 8751851, ECO 0000269|PubMed 8923011, ECO 0000269|PubMed 9618169, ECO 0000269|PubMed 9769320}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ABCC8_HUMAN	Leucine-induced hypoglycemia (LIH) [MIM 240800]  Rare cause of hypoglycemia and is described as a condition in which symptomatic hypoglycemia is provoked by high protein feedings. Hypoglycemia is also elicited by administration of oral or intravenous infusions of a single amino acid, leucine. {ECO 0000269|PubMed 15356046}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ABCC8_HUMAN	Transient neonatal diabetes mellitus 2 (TNDM2) [MIM 610374]  Neonatal diabetes is a form of diabetes mellitus defined by the onset of mild-to-severe hyperglycemia within the first months of life. Transient neonatal diabetes remits early, with a possible relapse during adolescence. {ECO 0000269|PubMed 16885549}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00171	Adenosine triphosphate
# DrugBank	DB00222	Glimepiride
# DrugBank	DB00672	Chlorpropamide
# DrugBank	DB00731	Nateglinide
# DrugBank	DB00912	Repaglinide
# DrugBank	DB01016	Glyburide
# DrugBank	DB01067	Glipizide
# DrugBank	DB01120	Gliclazide
# DrugBank	DB01124	Tolbutamide
# DrugBank	DB01251	Gliquidone
# DrugBank	DB01252	Mitiglinide
# DrugBank	DB01382	Glycodiazine
# Ensembl	ENST00000302539	ENSP00000303960; ENSG00000006071. [Q09428-2]
# Ensembl	ENST00000389817	ENSP00000374467; ENSG00000006071. [Q09428-1]
# Ensembl	ENST00000612903	ENSP00000483031; ENSG00000006071. [Q09428-3]
# ExpressionAtlas	Q09428	baseline and differential
# FUNCTION	ABCC8_HUMAN	Subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release. {ECO 0000269|PubMed 24814349, ECO 0000269|PubMed 25720052}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IDA:BHF-UCL.
# GO_component	GO:0030672	synaptic vesicle membrane; IEA:Ensembl.
# GO_component	GO:0042383	sarcolemma; IEA:Ensembl.
# GO_function	GO:0005267	potassium channel activity; IMP:UniProtKB.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0008281	sulfonylurea receptor activity; IEA:InterPro.
# GO_function	GO:0015272	ATP-activated inward rectifier potassium channel activity; TAS:Reactome.
# GO_function	GO:0043225	ATPase-coupled anion transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0044325	ion channel binding; IPI:BHF-UCL.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0009268	response to pH; IEA:Ensembl.
# GO_process	GO:0010043	response to zinc ion; IEA:Ensembl.
# GO_process	GO:0032496	response to lipopolysaccharide; IEA:Ensembl.
# GO_process	GO:0032868	response to insulin; IEA:Ensembl.
# GO_process	GO:0042493	response to drug; IEA:Ensembl.
# GO_process	GO:0043268	positive regulation of potassium ion transport; IEA:Ensembl.
# GO_process	GO:0046676	negative regulation of insulin secretion; IEA:Ensembl.
# GO_process	GO:0050796	regulation of insulin secretion; TAS:Reactome.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GO_process	GO:0071310	cellular response to organic substance; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 2.
# Genevisible	Q09428	HS
# HGNC	HGNC:59	ABCC8
# InterPro	IPR000388	Sulphorea_rcpt
# InterPro	IPR000844	ABCC8
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR011527	ABC1_TM_dom
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00512	[Metabolic disease; Endocrine disease] Permanent neonatal diabetes mellitus (PNDM)
# KEGG_Disease	H00513	[Metabolic disease; Endocrine disease] Transient neonatal diabetes mellitus (TNDM)
# KEGG_Disease	H01267	[Inherited metabolic disease] Familial hyperinsulinemic hypoglycemia (HHF)
# KEGG_Pathway	ko02010	ABC transporters
# KEGG_Pathway	ko04930	Type II diabetes mellitus
# MIM	240800	phenotype
# MIM	256450	phenotype
# MIM	600509	gene
# MIM	602485	phenotype
# MIM	606176	phenotype
# MIM	610374	phenotype
# Organism	ABCC8_HUMAN	Homo sapiens (Human)
# Orphanet	276575	Autosomal dominant hyperinsulinism due to SUR1 deficiency
# Orphanet	276598	Diazoxide-resistant focal hyperinsulinism due to SUR1 deficiency
# Orphanet	552	MODY
# Orphanet	79134	DEND syndrome
# Orphanet	79643	Autosomal recessive hyperinsulinism due to SUR1 deficiency
# Orphanet	99885	Permanent neonatal diabetes mellitus
# Orphanet	99886	Transient neonatal diabetes mellitus
# PANTHER	PTHR24223:SF187	PTHR24223:SF187; 4
# PRINTS	PR01092	SULFNYLUREAR
# PRINTS	PR01093	SULFNYLUR1
# PROSITE	PS00211	ABC_TRANSPORTER_1; 2
# PROSITE	PS50893	ABC_TRANSPORTER_2; 2
# PROSITE	PS50929	ABC_TM1F; 2
# Pfam	PF00005	ABC_tran; 2
# Pfam	PF00664	ABC_membrane; 2
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-1296025	ATP sensitive Potassium channels
# Reactome	R-HSA-382556	ABC-family proteins mediated transport
# Reactome	R-HSA-422356	Regulation of insulin secretion
# Reactome	R-HSA-5683177	Defective ABCC8 can cause hypoglycemias and hyperglycemias
# RecName	ABCC8_HUMAN	ATP-binding cassette sub-family C member 8
# RefSeq	NP_000343	NM_000352.4. [Q09428-1]
# RefSeq	NP_001274103	NM_001287174.1. [Q09428-2]
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 2 ABC transmembrane type-1 domains. {ECO:0000255|PROSITE-ProRule	PRU00441}. 
# SIMILARITY	Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA; 2
# SUBCELLULAR LOCATION	ABCC8_HUMAN	Cell membrane {ECO 0000269|PubMed 24814349}; Multi-pass membrane protein {ECO 0000255}. 
# SUBUNIT	ABCC8_HUMAN	Interacts with KCNJ11. 
# SUPFAM	SSF52540	SSF52540; 2
# SUPFAM	SSF90123	SSF90123; 2
# TCDB	3.A.1.208	the atp-binding cassette (abc) superfamily
# UCSC	uc001mnc	human. [Q09428-1]
# WEB RESOURCE	ABCC8_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=Q09428";
# eggNOG	COG1132	LUCA
# eggNOG	KOG0054	Eukaryota
BLAST	swissprot:ABCC8_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCC8_HUMAN
BioCyc	ZFISH:ENSG00000006071-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000006071-MONOMER
COXPRESdb	6833	http://coxpresdb.jp/data/gene/6833.shtml
CleanEx	HS_ABCC8	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCC8
DIP	DIP-58642N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-58642N
DOI	10.1002/(SICI)1098-1004(1999)13:5<351::AID-HUMU3>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1999)13:5<351::AID-HUMU3>3.0.CO
DOI	10.1002/(SICI)1098-1004(1999)14:1<23::AID-HUMU3>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1999)14:1<23::AID-HUMU3>3.0.CO
DOI	10.1002/humu.9401	http://dx.doi.org/10.1002/humu.9401
DOI	10.1007/s00018-011-0739-x	http://dx.doi.org/10.1007/s00018-011-0739-x
DOI	10.1038/modpathol.3800497	http://dx.doi.org/10.1038/modpathol.3800497
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1056/NEJM199904153401505	http://dx.doi.org/10.1056/NEJM199904153401505
DOI	10.1056/NEJMoa055068	http://dx.doi.org/10.1056/NEJMoa055068
DOI	10.1073/pnas.051499698	http://dx.doi.org/10.1073/pnas.051499698
DOI	10.1074/jbc.274.41.29122	http://dx.doi.org/10.1074/jbc.274.41.29122
DOI	10.1074/jbc.M200363200	http://dx.doi.org/10.1074/jbc.M200363200
DOI	10.1086/519174	http://dx.doi.org/10.1086/519174
DOI	10.1093/hmg/5.11.1813	http://dx.doi.org/10.1093/hmg/5.11.1813
DOI	10.1093/hmg/7.7.1119	http://dx.doi.org/10.1093/hmg/7.7.1119
DOI	10.1093/hmg/ddl101	http://dx.doi.org/10.1093/hmg/ddl101
DOI	10.1111/cge.12428	http://dx.doi.org/10.1111/cge.12428
DOI	10.1111/j.1365-2265.2005.02242.x	http://dx.doi.org/10.1111/j.1365-2265.2005.02242.x
DOI	10.1126/science.272.5269.1785	http://dx.doi.org/10.1126/science.272.5269.1785
DOI	10.1126/science.7716548	http://dx.doi.org/10.1126/science.7716548
DOI	10.1172/JCI4495	http://dx.doi.org/10.1172/JCI4495
DOI	10.1172/JCI9804	http://dx.doi.org/10.1172/JCI9804
DOI	10.1210/edrv.20.2.0361	http://dx.doi.org/10.1210/edrv.20.2.0361
DOI	10.1210/jc.2002-020378	http://dx.doi.org/10.1210/jc.2002-020378
DOI	10.1210/jc.2004-0441	http://dx.doi.org/10.1210/jc.2004-0441
DOI	10.1210/jc.2004-1233	http://dx.doi.org/10.1210/jc.2004-1233
DOI	10.1210/jc.2004-1604	http://dx.doi.org/10.1210/jc.2004-1604
DOI	10.1210/jc.2006-2490	http://dx.doi.org/10.1210/jc.2006-2490
DOI	10.1515/jpem-2014-0265	http://dx.doi.org/10.1515/jpem-2014-0265
DOI	10.2337/diab.45.6.825	http://dx.doi.org/10.2337/diab.45.6.825
DOI	10.2337/diabetes.47.3.476	http://dx.doi.org/10.2337/diabetes.47.3.476
DOI	10.2337/diabetes.47.4.598	http://dx.doi.org/10.2337/diabetes.47.4.598
DOI	10.2337/diabetes.47.7.1145	http://dx.doi.org/10.2337/diabetes.47.7.1145
DOI	10.2337/diabetes.48.2.408	http://dx.doi.org/10.2337/diabetes.48.2.408
DOI	10.2337/diabetes.49.1.114	http://dx.doi.org/10.2337/diabetes.49.1.114
DOI	10.2337/diabetes.52.9.2403	http://dx.doi.org/10.2337/diabetes.52.9.2403
DrugBank	DB00171	http://www.drugbank.ca/drugs/DB00171
DrugBank	DB00222	http://www.drugbank.ca/drugs/DB00222
DrugBank	DB00672	http://www.drugbank.ca/drugs/DB00672
DrugBank	DB00731	http://www.drugbank.ca/drugs/DB00731
DrugBank	DB00912	http://www.drugbank.ca/drugs/DB00912
DrugBank	DB01016	http://www.drugbank.ca/drugs/DB01016
DrugBank	DB01067	http://www.drugbank.ca/drugs/DB01067
DrugBank	DB01120	http://www.drugbank.ca/drugs/DB01120
DrugBank	DB01124	http://www.drugbank.ca/drugs/DB01124
DrugBank	DB01251	http://www.drugbank.ca/drugs/DB01251
DrugBank	DB01252	http://www.drugbank.ca/drugs/DB01252
DrugBank	DB01382	http://www.drugbank.ca/drugs/DB01382
EMBL	AC124798	http://www.ebi.ac.uk/ena/data/view/AC124798
EMBL	AF087138	http://www.ebi.ac.uk/ena/data/view/AF087138
EMBL	HM635782	http://www.ebi.ac.uk/ena/data/view/HM635782
EMBL	L40625	http://www.ebi.ac.uk/ena/data/view/L40625
EMBL	L78207	http://www.ebi.ac.uk/ena/data/view/L78207
EMBL	L78208	http://www.ebi.ac.uk/ena/data/view/L78208
EMBL	L78208	http://www.ebi.ac.uk/ena/data/view/L78208
EMBL	L78209	http://www.ebi.ac.uk/ena/data/view/L78209
EMBL	L78209	http://www.ebi.ac.uk/ena/data/view/L78209
EMBL	L78210	http://www.ebi.ac.uk/ena/data/view/L78210
EMBL	L78210	http://www.ebi.ac.uk/ena/data/view/L78210
EMBL	L78211	http://www.ebi.ac.uk/ena/data/view/L78211
EMBL	L78211	http://www.ebi.ac.uk/ena/data/view/L78211
EMBL	L78212	http://www.ebi.ac.uk/ena/data/view/L78212
EMBL	L78212	http://www.ebi.ac.uk/ena/data/view/L78212
EMBL	L78213	http://www.ebi.ac.uk/ena/data/view/L78213
EMBL	L78213	http://www.ebi.ac.uk/ena/data/view/L78213
EMBL	L78214	http://www.ebi.ac.uk/ena/data/view/L78214
EMBL	L78214	http://www.ebi.ac.uk/ena/data/view/L78214
EMBL	L78215	http://www.ebi.ac.uk/ena/data/view/L78215
EMBL	L78215	http://www.ebi.ac.uk/ena/data/view/L78215
EMBL	L78216	http://www.ebi.ac.uk/ena/data/view/L78216
EMBL	L78216	http://www.ebi.ac.uk/ena/data/view/L78216
EMBL	L78217	http://www.ebi.ac.uk/ena/data/view/L78217
EMBL	L78217	http://www.ebi.ac.uk/ena/data/view/L78217
EMBL	L78218	http://www.ebi.ac.uk/ena/data/view/L78218
EMBL	L78218	http://www.ebi.ac.uk/ena/data/view/L78218
EMBL	L78219	http://www.ebi.ac.uk/ena/data/view/L78219
EMBL	L78219	http://www.ebi.ac.uk/ena/data/view/L78219
EMBL	L78220	http://www.ebi.ac.uk/ena/data/view/L78220
EMBL	L78220	http://www.ebi.ac.uk/ena/data/view/L78220
EMBL	L78221	http://www.ebi.ac.uk/ena/data/view/L78221
EMBL	L78221	http://www.ebi.ac.uk/ena/data/view/L78221
EMBL	L78222	http://www.ebi.ac.uk/ena/data/view/L78222
EMBL	L78222	http://www.ebi.ac.uk/ena/data/view/L78222
EMBL	L78223	http://www.ebi.ac.uk/ena/data/view/L78223
EMBL	L78224	http://www.ebi.ac.uk/ena/data/view/L78224
EMBL	L78225	http://www.ebi.ac.uk/ena/data/view/L78225
EMBL	L78225	http://www.ebi.ac.uk/ena/data/view/L78225
EMBL	L78226	http://www.ebi.ac.uk/ena/data/view/L78226
EMBL	L78226	http://www.ebi.ac.uk/ena/data/view/L78226
EMBL	L78227	http://www.ebi.ac.uk/ena/data/view/L78227
EMBL	L78227	http://www.ebi.ac.uk/ena/data/view/L78227
EMBL	L78228	http://www.ebi.ac.uk/ena/data/view/L78228
EMBL	L78228	http://www.ebi.ac.uk/ena/data/view/L78228
EMBL	L78229	http://www.ebi.ac.uk/ena/data/view/L78229
EMBL	L78229	http://www.ebi.ac.uk/ena/data/view/L78229
EMBL	L78230	http://www.ebi.ac.uk/ena/data/view/L78230
EMBL	L78230	http://www.ebi.ac.uk/ena/data/view/L78230
EMBL	L78231	http://www.ebi.ac.uk/ena/data/view/L78231
EMBL	L78231	http://www.ebi.ac.uk/ena/data/view/L78231
EMBL	L78232	http://www.ebi.ac.uk/ena/data/view/L78232
EMBL	L78232	http://www.ebi.ac.uk/ena/data/view/L78232
EMBL	L78233	http://www.ebi.ac.uk/ena/data/view/L78233
EMBL	L78233	http://www.ebi.ac.uk/ena/data/view/L78233
EMBL	L78234	http://www.ebi.ac.uk/ena/data/view/L78234
EMBL	L78234	http://www.ebi.ac.uk/ena/data/view/L78234
EMBL	L78235	http://www.ebi.ac.uk/ena/data/view/L78235
EMBL	L78235	http://www.ebi.ac.uk/ena/data/view/L78235
EMBL	L78236	http://www.ebi.ac.uk/ena/data/view/L78236
EMBL	L78236	http://www.ebi.ac.uk/ena/data/view/L78236
EMBL	L78237	http://www.ebi.ac.uk/ena/data/view/L78237
EMBL	L78237	http://www.ebi.ac.uk/ena/data/view/L78237
EMBL	L78238	http://www.ebi.ac.uk/ena/data/view/L78238
EMBL	L78238	http://www.ebi.ac.uk/ena/data/view/L78238
EMBL	L78239	http://www.ebi.ac.uk/ena/data/view/L78239
EMBL	L78239	http://www.ebi.ac.uk/ena/data/view/L78239
EMBL	L78240	http://www.ebi.ac.uk/ena/data/view/L78240
EMBL	L78240	http://www.ebi.ac.uk/ena/data/view/L78240
EMBL	L78241	http://www.ebi.ac.uk/ena/data/view/L78241
EMBL	L78241	http://www.ebi.ac.uk/ena/data/view/L78241
EMBL	L78242	http://www.ebi.ac.uk/ena/data/view/L78242
EMBL	L78242	http://www.ebi.ac.uk/ena/data/view/L78242
EMBL	L78243	http://www.ebi.ac.uk/ena/data/view/L78243
EMBL	L78243	http://www.ebi.ac.uk/ena/data/view/L78243
EMBL	L78254	http://www.ebi.ac.uk/ena/data/view/L78254
EMBL	L78254	http://www.ebi.ac.uk/ena/data/view/L78254
EMBL	L78255	http://www.ebi.ac.uk/ena/data/view/L78255
EMBL	L78255	http://www.ebi.ac.uk/ena/data/view/L78255
EMBL	U63421	http://www.ebi.ac.uk/ena/data/view/U63421
EMBL	U63422	http://www.ebi.ac.uk/ena/data/view/U63422
EMBL	U63423	http://www.ebi.ac.uk/ena/data/view/U63423
EMBL	U63424	http://www.ebi.ac.uk/ena/data/view/U63424
EMBL	U63425	http://www.ebi.ac.uk/ena/data/view/U63425
EMBL	U63426	http://www.ebi.ac.uk/ena/data/view/U63426
EMBL	U63427	http://www.ebi.ac.uk/ena/data/view/U63427
EMBL	U63428	http://www.ebi.ac.uk/ena/data/view/U63428
EMBL	U63429	http://www.ebi.ac.uk/ena/data/view/U63429
EMBL	U63430	http://www.ebi.ac.uk/ena/data/view/U63430
EMBL	U63431	http://www.ebi.ac.uk/ena/data/view/U63431
EMBL	U63432	http://www.ebi.ac.uk/ena/data/view/U63432
EMBL	U63433	http://www.ebi.ac.uk/ena/data/view/U63433
EMBL	U63434	http://www.ebi.ac.uk/ena/data/view/U63434
EMBL	U63435	http://www.ebi.ac.uk/ena/data/view/U63435
EMBL	U63436	http://www.ebi.ac.uk/ena/data/view/U63436
EMBL	U63437	http://www.ebi.ac.uk/ena/data/view/U63437
EMBL	U63438	http://www.ebi.ac.uk/ena/data/view/U63438
EMBL	U63439	http://www.ebi.ac.uk/ena/data/view/U63439
EMBL	U63441	http://www.ebi.ac.uk/ena/data/view/U63441
EMBL	U63442	http://www.ebi.ac.uk/ena/data/view/U63442
EMBL	U63443	http://www.ebi.ac.uk/ena/data/view/U63443
EMBL	U63444	http://www.ebi.ac.uk/ena/data/view/U63444
EMBL	U63445	http://www.ebi.ac.uk/ena/data/view/U63445
EMBL	U63446	http://www.ebi.ac.uk/ena/data/view/U63446
EMBL	U63447	http://www.ebi.ac.uk/ena/data/view/U63447
EMBL	U63448	http://www.ebi.ac.uk/ena/data/view/U63448
EMBL	U63449	http://www.ebi.ac.uk/ena/data/view/U63449
EMBL	U63450	http://www.ebi.ac.uk/ena/data/view/U63450
EMBL	U63451	http://www.ebi.ac.uk/ena/data/view/U63451
EMBL	U63452	http://www.ebi.ac.uk/ena/data/view/U63452
EMBL	U63453	http://www.ebi.ac.uk/ena/data/view/U63453
EMBL	U63454	http://www.ebi.ac.uk/ena/data/view/U63454
EMBL	U63455	http://www.ebi.ac.uk/ena/data/view/U63455
Ensembl	ENST00000302539	http://www.ensembl.org/id/ENST00000302539
Ensembl	ENST00000389817	http://www.ensembl.org/id/ENST00000389817
Ensembl	ENST00000612903	http://www.ensembl.org/id/ENST00000612903
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0030672	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030672
GO_component	GO:0042383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042383
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0008281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008281
GO_function	GO:0015272	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015272
GO_function	GO:0043225	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043225
GO_function	GO:0044325	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044325
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0009268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009268
GO_process	GO:0010043	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010043
GO_process	GO:0032496	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032496
GO_process	GO:0032868	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032868
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0043268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043268
GO_process	GO:0046676	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046676
GO_process	GO:0050796	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050796
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GO_process	GO:0071310	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071310
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCC8	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCC8
GeneID	6833	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6833
GeneTree	ENSGT00860000133722	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00860000133722
H-InvDB	HIX0035864	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0035864
HGNC	HGNC:59	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:59
HOVERGEN	HBG101342	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG101342&db=HOVERGEN
HPA	CAB011451	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB011451
HPA	HPA042318	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042318
InParanoid	Q09428	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q09428
InterPro	IPR000388	http://www.ebi.ac.uk/interpro/entry/IPR000388
InterPro	IPR000844	http://www.ebi.ac.uk/interpro/entry/IPR000844
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR011527	http://www.ebi.ac.uk/interpro/entry/IPR011527
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	6833	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6833
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00512	http://www.genome.jp/dbget-bin/www_bget?H00512
KEGG_Disease	H00513	http://www.genome.jp/dbget-bin/www_bget?H00513
KEGG_Disease	H01267	http://www.genome.jp/dbget-bin/www_bget?H01267
KEGG_Gene	hsa:6833	http://www.genome.jp/dbget-bin/www_bget?hsa:6833
KEGG_Orthology	KO:K05032	http://www.genome.jp/dbget-bin/www_bget?KO:K05032
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
KEGG_Pathway	ko04930	http://www.genome.jp/kegg-bin/show_pathway?ko04930
MIM	240800	http://www.ncbi.nlm.nih.gov/omim/240800
MIM	256450	http://www.ncbi.nlm.nih.gov/omim/256450
MIM	600509	http://www.ncbi.nlm.nih.gov/omim/600509
MIM	602485	http://www.ncbi.nlm.nih.gov/omim/602485
MIM	606176	http://www.ncbi.nlm.nih.gov/omim/606176
MIM	610374	http://www.ncbi.nlm.nih.gov/omim/610374
OMA	QGQASKY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QGQASKY
Orphanet	276575	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=276575
Orphanet	276598	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=276598
Orphanet	552	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=552
Orphanet	79134	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=79134
Orphanet	79643	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=79643
Orphanet	99885	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=99885
Orphanet	99886	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=99886
OrthoDB	EOG091G00IN	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00IN
PANTHER	PTHR24223:SF187	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24223:SF187
PRINTS	PR01092	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01092
PRINTS	PR01093	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01093
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PROSITE	PS50929	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929
PSORT	swissprot:ABCC8_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCC8_HUMAN
PSORT-B	swissprot:ABCC8_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCC8_HUMAN
PSORT2	swissprot:ABCC8_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCC8_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF00664	http://pfam.xfam.org/family/PF00664
PharmGKB	PA24395	http://www.pharmgkb.org/do/serve?objId=PA24395&objCls=Gene
Phobius	swissprot:ABCC8_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCC8_HUMAN
PhylomeDB	Q09428	http://phylomedb.org/?seqid=Q09428
ProteinModelPortal	Q09428	http://www.proteinmodelportal.org/query/uniprot/Q09428
PubMed	10202168	http://www.ncbi.nlm.nih.gov/pubmed/10202168
PubMed	10204114	http://www.ncbi.nlm.nih.gov/pubmed/10204114
PubMed	10334322	http://www.ncbi.nlm.nih.gov/pubmed/10334322
PubMed	10338089	http://www.ncbi.nlm.nih.gov/pubmed/10338089
PubMed	10447255	http://www.ncbi.nlm.nih.gov/pubmed/10447255
PubMed	10506167	http://www.ncbi.nlm.nih.gov/pubmed/10506167
PubMed	10615958	http://www.ncbi.nlm.nih.gov/pubmed/10615958
PubMed	11018078	http://www.ncbi.nlm.nih.gov/pubmed/11018078
PubMed	11226335	http://www.ncbi.nlm.nih.gov/pubmed/11226335
PubMed	11867634	http://www.ncbi.nlm.nih.gov/pubmed/11867634
PubMed	12364426	http://www.ncbi.nlm.nih.gov/pubmed/12364426
PubMed	12941782	http://www.ncbi.nlm.nih.gov/pubmed/12941782
PubMed	15356046	http://www.ncbi.nlm.nih.gov/pubmed/15356046
PubMed	15562009	http://www.ncbi.nlm.nih.gov/pubmed/15562009
PubMed	15579781	http://www.ncbi.nlm.nih.gov/pubmed/15579781
PubMed	15807877	http://www.ncbi.nlm.nih.gov/pubmed/15807877
PubMed	16357843	http://www.ncbi.nlm.nih.gov/pubmed/16357843
PubMed	16429405	http://www.ncbi.nlm.nih.gov/pubmed/16429405
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	16613899	http://www.ncbi.nlm.nih.gov/pubmed/16613899
PubMed	16885549	http://www.ncbi.nlm.nih.gov/pubmed/16885549
PubMed	17213273	http://www.ncbi.nlm.nih.gov/pubmed/17213273
PubMed	17668386	http://www.ncbi.nlm.nih.gov/pubmed/17668386
PubMed	21671119	http://www.ncbi.nlm.nih.gov/pubmed/21671119
PubMed	24814349	http://www.ncbi.nlm.nih.gov/pubmed/24814349
PubMed	25720052	http://www.ncbi.nlm.nih.gov/pubmed/25720052
PubMed	7716548	http://www.ncbi.nlm.nih.gov/pubmed/7716548
PubMed	8635661	http://www.ncbi.nlm.nih.gov/pubmed/8635661
PubMed	8650576	http://www.ncbi.nlm.nih.gov/pubmed/8650576
PubMed	8751851	http://www.ncbi.nlm.nih.gov/pubmed/8751851
PubMed	8923011	http://www.ncbi.nlm.nih.gov/pubmed/8923011
PubMed	9519757	http://www.ncbi.nlm.nih.gov/pubmed/9519757
PubMed	9568693	http://www.ncbi.nlm.nih.gov/pubmed/9568693
PubMed	9618169	http://www.ncbi.nlm.nih.gov/pubmed/9618169
PubMed	9648840	http://www.ncbi.nlm.nih.gov/pubmed/9648840
PubMed	9769320	http://www.ncbi.nlm.nih.gov/pubmed/9769320
Reactome	R-HSA-1296025	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296025
Reactome	R-HSA-382556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-382556
Reactome	R-HSA-422356	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-422356
Reactome	R-HSA-5683177	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5683177
RefSeq	NP_000343	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000343
RefSeq	NP_001274103	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001274103
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
STRING	9606.ENSP00000374467	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000374467&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
SUPFAM	SSF90123	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123
TCDB	3.A.1.208	http://www.tcdb.org/search/result.php?tc=3.A.1.208
UCSC	uc001mnc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001mnc&org=rat
UniGene	Hs.54470	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.54470
UniProtKB	ABCC8_HUMAN	http://www.uniprot.org/uniprot/ABCC8_HUMAN
UniProtKB-AC	Q09428	http://www.uniprot.org/uniprot/Q09428
charge	swissprot:ABCC8_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCC8_HUMAN
eggNOG	COG1132	http://eggnogapi.embl.de/nog_data/html/tree/COG1132
eggNOG	KOG0054	http://eggnogapi.embl.de/nog_data/html/tree/KOG0054
epestfind	swissprot:ABCC8_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCC8_HUMAN
garnier	swissprot:ABCC8_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCC8_HUMAN
helixturnhelix	swissprot:ABCC8_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCC8_HUMAN
hmoment	swissprot:ABCC8_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCC8_HUMAN
iep	swissprot:ABCC8_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCC8_HUMAN
inforesidue	swissprot:ABCC8_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCC8_HUMAN
neXtProt	NX_Q09428	http://www.nextprot.org/db/entry/NX_Q09428
octanol	swissprot:ABCC8_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCC8_HUMAN
pepcoil	swissprot:ABCC8_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCC8_HUMAN
pepdigest	swissprot:ABCC8_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCC8_HUMAN
pepinfo	swissprot:ABCC8_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCC8_HUMAN
pepnet	swissprot:ABCC8_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCC8_HUMAN
pepstats	swissprot:ABCC8_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCC8_HUMAN
pepwheel	swissprot:ABCC8_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCC8_HUMAN
pepwindow	swissprot:ABCC8_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCC8_HUMAN
sigcleave	swissprot:ABCC8_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCC8_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CA2D4_HUMAN	Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=Alpha2delta-4a; IsoId=Q7Z3S7-1; Sequence=Displayed; Name=2; IsoId=Q7Z3S7-2; Sequence=VSP_028070; Note=No experimental confirmation available. May be due to an intron retention.; Name=4; Synonyms=Alpha2delta-4b; IsoId=Q7Z3S7-4; Sequence=VSP_028069; Name=5; Synonyms=Alpha2delta-4c; IsoId=Q7Z3S7-5; Sequence=VSP_028071; Name=6; Synonyms=Alpha2delta-4d; IsoId=Q7Z3S7-6; Sequence=VSP_028069, VSP_028071; Name=7; IsoId=Q7Z3S7-7; Sequence=VSP_044107, VSP_044108, VSP_044109, VSP_044110; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 
# AltName	CA2D4_HUMAN	Voltage-gated calcium channel subunit alpha-2/delta-4
# AltName	CA2D4_HUMAN	Voltage-gated calcium channel subunit alpha-2/delta-4
# CCDS	CCDS44785	-. [Q7Z3S7-1]
# ChiTaRS	CACNA2D4	human
# DISEASE	CA2D4_HUMAN	Retinal cone dystrophy 4 (RCD4) [MIM 610478]  Characterized by minimal symptoms except for slowly progressive reduction in visual acuity. {ECO 0000269|PubMed 17033974}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	CA2D4_HUMAN	The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha- 1 (CACNA1) subunit to the plasma membrane by an integrin-like switch. {ECO 0000250}. 
# Ensembl	ENST00000382722	ENSP00000372169; ENSG00000151062. [Q7Z3S7-1]
# Ensembl	ENST00000545595	ENSP00000442329; ENSG00000151062. [Q7Z3S7-7]
# Ensembl	ENST00000585708	ENSP00000467697; ENSG00000151062. [Q7Z3S7-6]
# Ensembl	ENST00000586184	ENSP00000465060; ENSG00000151062. [Q7Z3S7-5]
# Ensembl	ENST00000588077	ENSP00000468530; ENSG00000151062. [Q7Z3S7-4]
# ExpressionAtlas	Q7Z3S7	baseline and differential
# FUNCTION	CA2D4_HUMAN	The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. {ECO 0000269|PubMed 12181424}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005891	voltage-gated calcium channel complex; IDA:UniProtKB.
# GO_function	GO:0005245	voltage-gated calcium channel activity; IDA:UniProtKB.
# GO_function	GO:0005246	calcium channel regulator activity; IBA:GO_Central.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0050908	detection of light stimulus involved in visual perception; IMP:UniProtKB.
# GO_process	GO:0051924	regulation of calcium ion transport; IBA:GO_Central.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:0070588	calcium ion transmembrane transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.410	-; 1.
# Genevisible	Q7Z3S7	HS
# HGNC	HGNC:20202	CACNA2D4
# InterPro	IPR002035	VWF_A
# InterPro	IPR013608	VWA_N
# InterPro	IPR013680	VDCC_a2/dsu
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00481	[Inherited metabolic disease; Nervous system disease; Eye disease] Retinal cone dystrophy (RCD)
# KEGG_Pathway	ko04010	MAPK signaling pathway
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05410	Hypertrophic cardiomyopathy (HCM)
# KEGG_Pathway	ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
# KEGG_Pathway	ko05414	Dilated cardiomyopathy
# MIM	608171	gene
# MIM	610478	phenotype
# MISCELLANEOUS	CA2D4_HUMAN	In contrast to CACNA2D1 and CACNA2D2, it does not bind gabapentin, an antiepileptic drug. 
# Organism	CA2D4_HUMAN	Homo sapiens (Human)
# Orphanet	1872	Cone rod dystrophy
# Orphanet	215	Congenital stationary night blindness
# PROSITE	PS50234	VWFA
# PTM	CA2D4_HUMAN	May be proteolytically processed into subunits alpha-2-4 and delta-4 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role (By similarity). {ECO 0000250}. 
# Pfam	PF08399	VWA_N
# Pfam	PF08473	VGCC_alpha2
# Pfam	PF13768	VWA_3
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# Reactome	R-HSA-5576893	Phase 2 - plateau phase
# Reactome	R-HSA-5576894	Phase 1 - inactivation of fast Na+ channels
# RecName	CA2D4_HUMAN	Voltage-dependent calcium channel subunit alpha-2-4
# RecName	CA2D4_HUMAN	Voltage-dependent calcium channel subunit alpha-2-4
# RecName	CA2D4_HUMAN	Voltage-dependent calcium channel subunit alpha-2/delta-4
# RecName	CA2D4_HUMAN	Voltage-dependent calcium channel subunit delta-4
# RefSeq	NP_758952	NM_172364.4. [Q7Z3S7-1]
# SEQUENCE CAUTION	Sequence=AAH48288.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=AAN06672.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the calcium channel subunit alpha-2/delta family. {ECO	0000305}. 
# SIMILARITY	Contains 1 VWFA domain. {ECO:0000255|PROSITE- ProRule	PRU00219}. 
# SIMILARITY	Contains 1 cache domain. {ECO	0000305}. 
# SMART	SM00327	VWA
# SUBCELLULAR LOCATION	CA2D4_HUMAN	Membrane {ECO 0000305}; Single-pass type I membrane protein {ECO 0000305}. 
# SUBUNIT	CA2D4_HUMAN	Dimer formed of alpha-2-2 and delta-2 chains; disulfide- linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1 1 1 1 ratio (Probable). Interacts with CACNA1C and CACNB3. {ECO 0000269|PubMed 12181424, ECO 0000305}. 
# SUPFAM	SSF53300	SSF53300
# TCDB	8.A.18.4	the ca(2+) channel auxiliary subunit Alpha2Delta types 1-4 (cca-Alpha2Delta) family
# TISSUE SPECIFICITY	Predominantly expressed in certain types of endocrine cells. Present in the Paneth cells of the small intestine. Also present in the erythroblasts in the fetal liver, in the cells of the zona reticularis of the adrenal gland and in the basophils of the pituitary. Present at low level in some brain regions such as the cerebellum (at protein level). {ECO:0000269|PubMed	12181424}. 
# UCSC	uc058jsm	human. [Q7Z3S7-1]
# eggNOG	ENOG410XPDX	LUCA
# eggNOG	KOG2353	Eukaryota
BLAST	swissprot:CA2D4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CA2D4_HUMAN
COXPRESdb	93589	http://coxpresdb.jp/data/gene/93589.shtml
CleanEx	HS_CACNA2D4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CACNA2D4
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1086/508944	http://dx.doi.org/10.1086/508944
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1124/mol.62.3.485	http://dx.doi.org/10.1124/mol.62.3.485
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AC005342	http://www.ebi.ac.uk/ena/data/view/AC005342
EMBL	AC005343	http://www.ebi.ac.uk/ena/data/view/AC005343
EMBL	AF516695	http://www.ebi.ac.uk/ena/data/view/AF516695
EMBL	BC048288	http://www.ebi.ac.uk/ena/data/view/BC048288
EMBL	BX537436	http://www.ebi.ac.uk/ena/data/view/BX537436
EMBL	BX537437	http://www.ebi.ac.uk/ena/data/view/BX537437
Ensembl	ENST00000382722	http://www.ensembl.org/id/ENST00000382722
Ensembl	ENST00000545595	http://www.ensembl.org/id/ENST00000545595
Ensembl	ENST00000585708	http://www.ensembl.org/id/ENST00000585708
Ensembl	ENST00000586184	http://www.ensembl.org/id/ENST00000586184
Ensembl	ENST00000588077	http://www.ensembl.org/id/ENST00000588077
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005891
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0005246	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005246
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0050908	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050908
GO_process	GO:0051924	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051924
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.410	http://www.cathdb.info/version/latest/superfamily/3.40.50.410
GeneCards	CACNA2D4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CACNA2D4
GeneID	93589	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=93589
GeneTree	ENSGT00530000062904	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062904
H-InvDB	HIX0010321	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0010321
H-InvDB	HIX0171624	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0171624
HGNC	HGNC:20202	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20202
HOGENOM	HOG000010247	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000010247&db=HOGENOM6
HOVERGEN	HBG107124	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG107124&db=HOVERGEN
HPA	HPA031952	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031952
InParanoid	Q7Z3S7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q7Z3S7
InterPro	IPR002035	http://www.ebi.ac.uk/interpro/entry/IPR002035
InterPro	IPR013608	http://www.ebi.ac.uk/interpro/entry/IPR013608
InterPro	IPR013680	http://www.ebi.ac.uk/interpro/entry/IPR013680
Jabion	93589	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=93589
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00481	http://www.genome.jp/dbget-bin/www_bget?H00481
KEGG_Gene	hsa:93589	http://www.genome.jp/dbget-bin/www_bget?hsa:93589
KEGG_Orthology	KO:K04861	http://www.genome.jp/dbget-bin/www_bget?KO:K04861
KEGG_Pathway	ko04010	http://www.genome.jp/kegg-bin/show_pathway?ko04010
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05410	http://www.genome.jp/kegg-bin/show_pathway?ko05410
KEGG_Pathway	ko05412	http://www.genome.jp/kegg-bin/show_pathway?ko05412
KEGG_Pathway	ko05414	http://www.genome.jp/kegg-bin/show_pathway?ko05414
MIM	608171	http://www.ncbi.nlm.nih.gov/omim/608171
MIM	610478	http://www.ncbi.nlm.nih.gov/omim/610478
OMA	VFNLRWA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VFNLRWA
Orphanet	1872	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1872
Orphanet	215	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=215
OrthoDB	EOG091G00UY	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00UY
PROSITE	PS50234	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50234
PSORT	swissprot:CA2D4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CA2D4_HUMAN
PSORT-B	swissprot:CA2D4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CA2D4_HUMAN
PSORT2	swissprot:CA2D4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CA2D4_HUMAN
Pfam	PF08399	http://pfam.xfam.org/family/PF08399
Pfam	PF08473	http://pfam.xfam.org/family/PF08473
Pfam	PF13768	http://pfam.xfam.org/family/PF13768
PharmGKB	PA130546913	http://www.pharmgkb.org/do/serve?objId=PA130546913&objCls=Gene
Phobius	swissprot:CA2D4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CA2D4_HUMAN
PhylomeDB	Q7Z3S7	http://phylomedb.org/?seqid=Q7Z3S7
ProteinModelPortal	Q7Z3S7	http://www.proteinmodelportal.org/query/uniprot/Q7Z3S7
PubMed	12181424	http://www.ncbi.nlm.nih.gov/pubmed/12181424
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	17033974	http://www.ncbi.nlm.nih.gov/pubmed/17033974
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
Reactome	R-HSA-5576893	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576893
Reactome	R-HSA-5576894	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576894
RefSeq	NP_758952	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_758952
SMART	SM00327	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00327
STRING	9606.ENSP00000372169	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000372169&targetmode=cogs
SUPFAM	SSF53300	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53300
TCDB	8.A.18.4	http://www.tcdb.org/search/result.php?tc=8.A.18.4
UCSC	uc058jsm	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc058jsm&org=rat
UniGene	Hs.13768	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.13768
UniProtKB	CA2D4_HUMAN	http://www.uniprot.org/uniprot/CA2D4_HUMAN
UniProtKB-AC	Q7Z3S7	http://www.uniprot.org/uniprot/Q7Z3S7
charge	swissprot:CA2D4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CA2D4_HUMAN
eggNOG	ENOG410XPDX	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPDX
eggNOG	KOG2353	http://eggnogapi.embl.de/nog_data/html/tree/KOG2353
epestfind	swissprot:CA2D4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CA2D4_HUMAN
garnier	swissprot:CA2D4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CA2D4_HUMAN
helixturnhelix	swissprot:CA2D4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CA2D4_HUMAN
hmoment	swissprot:CA2D4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CA2D4_HUMAN
iep	swissprot:CA2D4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CA2D4_HUMAN
inforesidue	swissprot:CA2D4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CA2D4_HUMAN
neXtProt	NX_Q7Z3S7	http://www.nextprot.org/db/entry/NX_Q7Z3S7
octanol	swissprot:CA2D4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CA2D4_HUMAN
pepcoil	swissprot:CA2D4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CA2D4_HUMAN
pepdigest	swissprot:CA2D4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CA2D4_HUMAN
pepinfo	swissprot:CA2D4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CA2D4_HUMAN
pepnet	swissprot:CA2D4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CA2D4_HUMAN
pepstats	swissprot:CA2D4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CA2D4_HUMAN
pepwheel	swissprot:CA2D4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CA2D4_HUMAN
pepwindow	swissprot:CA2D4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CA2D4_HUMAN
sigcleave	swissprot:CA2D4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CA2D4_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNA6_HUMAN	Voltage-gated potassium channel subunit Kv1.6
# AltName	Voltage-gated potassium channel HBK2 {ECO:0000303|PubMed	2347305}
# BioGrid	109944	11
# ChiTaRS	KCNA6	human
# DOMAIN	KCNA6_HUMAN	The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. 
# DOMAIN	KCNA6_HUMAN	The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. {ECO 0000250|UniProtKB P63142}. 
# DrugBank	DB06637	Dalfampridine
# Ensembl	ENST00000280684	ENSP00000280684; ENSG00000151079
# ExpressionAtlas	P17658	baseline and differential
# FUNCTION	KCNA6_HUMAN	Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed 2347305, PubMed 14575698). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed 2347305, PubMed 14575698). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). Homotetrameric channels display rapid activation and slow inactivation (PubMed 2347305). {ECO 0000250|UniProtKB P17659, ECO 0000269|PubMed 14575698, ECO 0000269|PubMed 2347305}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IMP:UniProtKB.
# GO_component	GO:0008076	voltage-gated potassium channel complex; ISS:UniProtKB.
# GO_component	GO:0034705	potassium channel complex; ISS:UniProtKB.
# GO_component	GO:0043679	axon terminus; IEA:Ensembl.
# GO_function	GO:0005249	voltage-gated potassium channel activity; TAS:ProtInc.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; IDA:UniProtKB.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0051260	protein homooligomerization; IEA:InterPro.
# GO_process	GO:0071805	potassium ion transmembrane transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.350	-; 1.
# Genevisible	P17658	HS
# HGNC	HGNC:6225	KCNA6
# IntAct	P17658	2
# InterPro	IPR000210	BTB/POZ_dom
# InterPro	IPR003131	T1-type_BTB
# InterPro	IPR003968	K_chnl_volt-dep_Kv
# InterPro	IPR003972	K_chnl_volt-dep_Kv1
# InterPro	IPR004053	K_chnl_volt-dep_Kv1.6
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR011333	SKP1/BTB/POZ
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko04040	Ion channels
# MIM	176257	gene
# Organism	KCNA6_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11537	PTHR11537; 3
# PIR	S12787	S12787
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01491	KVCHANNEL
# PRINTS	PR01496	SHAKERCHANEL
# PRINTS	PR01513	KV16CHANNEL
# Pfam	PF00520	Ion_trans
# Pfam	PF02214	BTB_2
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# RecName	KCNA6_HUMAN	Potassium voltage-gated channel subfamily A member 6
# RefSeq	NP_002226	NM_002235.3
# RefSeq	XP_005253743	XM_005253686.3
# RefSeq	XP_011519257	XM_011520955.2
# RefSeq	XP_016874759	XM_017019270.1
# RefSeq	XP_016874760	XM_017019271.1
# RefSeq	XP_016874761	XM_017019272.1
# SIMILARITY	Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.6/KCNA6 sub-subfamily. {ECO	0000305}.
# SMART	SM00225	BTB
# SUBCELLULAR LOCATION	KCNA6_HUMAN	Cell membrane {ECO 0000269|PubMed 14575698, ECO 0000269|PubMed 2347305}; Multi-pass membrane protein {ECO 0000305}. 
# SUBUNIT	Homotetramer and heterotetramer of potassium channel proteins (By similarity). Interacts with KCNAB1 and KCNAB2 (By similarity). {ECO:0000250|UniProtKB	P17659, ECO:0000305}. 
# SUPFAM	SSF54695	SSF54695
# UCSC	uc001qng	human
# eggNOG	COG1226	LUCA
# eggNOG	KOG1545	Eukaryota
BLAST	swissprot:KCNA6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNA6_HUMAN
BioCyc	ZFISH:ENSG00000151079-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000151079-MONOMER
COXPRESdb	3742	http://coxpresdb.jp/data/gene/3742.shtml
CleanEx	HS_KCNA6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNA6
DOI	10.1016/j.bbrc.2003.09.167	http://dx.doi.org/10.1016/j.bbrc.2003.09.167
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB06637	http://www.drugbank.ca/drugs/DB06637
EMBL	BC069355	http://www.ebi.ac.uk/ena/data/view/BC069355
EMBL	X17622	http://www.ebi.ac.uk/ena/data/view/X17622
Ensembl	ENST00000280684	http://www.ensembl.org/id/ENST00000280684
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0034705	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034705
GO_component	GO:0043679	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043679
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	KCNA6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNA6
GeneID	3742	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3742
GeneTree	ENSGT00670000097647	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00670000097647
GeneTree	ENSGT00760000118846	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118846
HGNC	HGNC:6225	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6225
HOGENOM	HOG000231015	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231015&db=HOGENOM6
HOVERGEN	HBG052230	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052230&db=HOVERGEN
HPA	CAB011539	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB011539
HPA	HPA014418	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014418
InParanoid	P17658	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P17658
IntAct	P17658	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P17658*
InterPro	IPR000210	http://www.ebi.ac.uk/interpro/entry/IPR000210
InterPro	IPR003131	http://www.ebi.ac.uk/interpro/entry/IPR003131
InterPro	IPR003968	http://www.ebi.ac.uk/interpro/entry/IPR003968
InterPro	IPR003972	http://www.ebi.ac.uk/interpro/entry/IPR003972
InterPro	IPR004053	http://www.ebi.ac.uk/interpro/entry/IPR004053
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR011333	http://www.ebi.ac.uk/interpro/entry/IPR011333
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	3742	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3742
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3742	http://www.genome.jp/dbget-bin/www_bget?hsa:3742
KEGG_Orthology	KO:K04879	http://www.genome.jp/dbget-bin/www_bget?KO:K04879
MIM	176257	http://www.ncbi.nlm.nih.gov/omim/176257
OMA	GKPEFSE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GKPEFSE
OrthoDB	EOG091G10NU	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G10NU
PANTHER	PTHR11537	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01491	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01491
PRINTS	PR01496	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01496
PRINTS	PR01513	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01513
PSORT	swissprot:KCNA6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNA6_HUMAN
PSORT-B	swissprot:KCNA6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNA6_HUMAN
PSORT2	swissprot:KCNA6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNA6_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF02214	http://pfam.xfam.org/family/PF02214
PharmGKB	PA30022	http://www.pharmgkb.org/do/serve?objId=PA30022&objCls=Gene
Phobius	swissprot:KCNA6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNA6_HUMAN
PhylomeDB	P17658	http://phylomedb.org/?seqid=P17658
ProteinModelPortal	P17658	http://www.proteinmodelportal.org/query/uniprot/P17658
PubMed	14575698	http://www.ncbi.nlm.nih.gov/pubmed/14575698
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	2347305	http://www.ncbi.nlm.nih.gov/pubmed/2347305
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
RefSeq	NP_002226	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002226
RefSeq	XP_005253743	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005253743
RefSeq	XP_011519257	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011519257
RefSeq	XP_016874759	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016874759
RefSeq	XP_016874760	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016874760
RefSeq	XP_016874761	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016874761
SMART	SM00225	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225
STRING	9606.ENSP00000280684	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000280684&targetmode=cogs
SUPFAM	SSF54695	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54695
UCSC	uc001qng	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001qng&org=rat
UniGene	Hs.306190	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.306190
UniProtKB	KCNA6_HUMAN	http://www.uniprot.org/uniprot/KCNA6_HUMAN
UniProtKB-AC	P17658	http://www.uniprot.org/uniprot/P17658
charge	swissprot:KCNA6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNA6_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG1545	http://eggnogapi.embl.de/nog_data/html/tree/KOG1545
epestfind	swissprot:KCNA6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNA6_HUMAN
garnier	swissprot:KCNA6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNA6_HUMAN
helixturnhelix	swissprot:KCNA6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNA6_HUMAN
hmoment	swissprot:KCNA6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNA6_HUMAN
iep	swissprot:KCNA6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNA6_HUMAN
inforesidue	swissprot:KCNA6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNA6_HUMAN
neXtProt	NX_P17658	http://www.nextprot.org/db/entry/NX_P17658
octanol	swissprot:KCNA6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNA6_HUMAN
pepcoil	swissprot:KCNA6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNA6_HUMAN
pepdigest	swissprot:KCNA6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNA6_HUMAN
pepinfo	swissprot:KCNA6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNA6_HUMAN
pepnet	swissprot:KCNA6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNA6_HUMAN
pepstats	swissprot:KCNA6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNA6_HUMAN
pepwheel	swissprot:KCNA6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNA6_HUMAN
pepwindow	swissprot:KCNA6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNA6_HUMAN
sigcleave	swissprot:KCNA6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNA6_HUMAN
## Database	ID	URL or Descriptions
# AltName	CXB3_HUMAN	Connexin-31
# BioGrid	108973	2
# ChiTaRS	GJB3	human
# DISEASE	CXB3_HUMAN	Deafness, autosomal dominant, 2B (DFNA2B) [MIM 612644]  A form of non-syndromic sensorineural deafness characterized by progressive high frequency hearing loss in adulthood, with milder expression in females. {ECO 0000269|PubMed 9843210}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CXB3_HUMAN	Erythrokeratodermia variabilis (EKV) [MIM 133200]  A genodermatosis characterized by the appearance of two independent skin lesions  transient figurate erythematous patches and hyperkeratosis that is usually localized but occasionally occurs in its generalized form. Clinical presentation varies significantly within a family and from one family to another. Palmoplantar keratoderma is present in around 50% of cases. {ECO 0000269|PubMed 10594760, ECO 0000269|PubMed 10798362, ECO 0000269|PubMed 9843209}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000373362	ENSP00000362460; ENSG00000188910
# Ensembl	ENST00000373366	ENSP00000362464; ENSG00000188910
# FUNCTION	CXB3_HUMAN	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. 
# GO_component	GO:0005737	cytoplasm; IEA:Ensembl.
# GO_component	GO:0005921	gap junction; NAS:UniProtKB.
# GO_component	GO:0005922	connexin complex; IEA:InterPro.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005243	gap junction channel activity; NAS:UniProtKB.
# GO_process	GO:0001701	in utero embryonic development; IEA:Ensembl.
# GO_process	GO:0001890	placenta development; IEA:Ensembl.
# GO_process	GO:0007154	cell communication; IEA:InterPro.
# GO_process	GO:0007605	sensory perception of sound; IEA:Ensembl.
# GO_process	GO:0043588	skin development; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009790	embryo development
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# Genevisible	O75712	HS
# HGNC	HGNC:4285	GJB3
# InterPro	IPR000500	Connexin
# InterPro	IPR002269	Connexin31
# InterPro	IPR013092	Connexin_N
# InterPro	IPR017990	Connexin_CS
# InterPro	IPR019570	Connexin_CCC
# KEGG_Disease	H00604	[Nervous system disease; Nervous system disease] Deafness, autosomal dominant
# KEGG_Disease	H00605	[Nervous system disease; Nervous system disease] Deafness, autosomal recessive
# KEGG_Disease	H00710	[Skin and connective tissue disease] Erythrokeratodermia variabilis
# MIM	133200	phenotype
# MIM	603324	gene+phenotype
# MIM	612644	phenotype
# Organism	CXB3_HUMAN	Homo sapiens (Human)
# Orphanet	139512	Neuropathy with hearing impairment
# Orphanet	317	Erythrokeratodermia variabilis
# Orphanet	90635	Autosomal dominant non-syndromic sensorineural deafness type DFNA
# Orphanet	90636	Autosomal recessive non-syndromic sensorineural deafness type DFNB
# PANTHER	PTHR11984	PTHR11984
# PANTHER	PTHR11984:SF65	PTHR11984:SF65
# PIR	JE0274	JE0274
# PRINTS	PR00206	CONNEXIN
# PRINTS	PR01140	CONNEXINB3
# PROSITE	PS00407	CONNEXINS_1
# PROSITE	PS00408	CONNEXINS_2
# Pfam	PF00029	Connexin
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-190861	Gap junction assembly
# RecName	CXB3_HUMAN	Gap junction beta-3 protein
# RefSeq	NP_001005752	NM_001005752.1
# RefSeq	NP_076872	NM_024009.2
# SIMILARITY	Belongs to the connexin family. Beta-type (group I) subfamily. {ECO	0000305}. 
# SMART	SM00037	CNX
# SMART	SM01089	Connexin_CCC
# SUBCELLULAR LOCATION	CXB3_HUMAN	Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. 
# SUBUNIT	A connexon is composed of a hexamer of connexins. Interacts with CNST (By similarity). {ECO	0000250}. 
# TCDB	1.A.24.1.10	the gap junction-forming connexin (connexin) family
# UCSC	uc001bxx	human
# WEB RESOURCE	CXB3_HUMAN	Name=Connexin-deafness homepage; URL="http //davinci.crg.es/deafness/"; 
# WEB RESOURCE	CXB3_HUMAN	Name=Hereditary hearing loss homepage; Note=Gene page; URL="http //hereditaryhearingloss.org/main.aspx?c=.HHH&n=86162";
# eggNOG	ENOG410IE21	Eukaryota
# eggNOG	ENOG410Y9C2	LUCA
BLAST	swissprot:CXB3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CXB3_HUMAN
BioCyc	ZFISH:G66-32642-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32642-MONOMER
COXPRESdb	2707	http://coxpresdb.jp/data/gene/2707.shtml
CleanEx	HS_GJB3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GJB3
DOI	10.1002/(SICI)1098-1004(200005)15:5<481::AID-HUMU15>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(200005)15:5<481::AID-HUMU15>3.0.CO
DOI	10.1002/ajmg.a.32765	http://dx.doi.org/10.1002/ajmg.a.32765
DOI	10.1006/bbrc.1998.9070	http://dx.doi.org/10.1006/bbrc.1998.9070
DOI	10.1007/s004390051045	http://dx.doi.org/10.1007/s004390051045
DOI	10.1038/3840	http://dx.doi.org/10.1038/3840
DOI	10.1038/3845	http://dx.doi.org/10.1038/3845
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.ejhg.5200407	http://dx.doi.org/10.1038/sj.ejhg.5200407
DOI	10.1046/j.1523-1747.1999.00792.x	http://dx.doi.org/10.1046/j.1523-1747.1999.00792.x
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF052692	http://www.ebi.ac.uk/ena/data/view/AF052692
EMBL	AF099730	http://www.ebi.ac.uk/ena/data/view/AF099730
EMBL	AJ004856	http://www.ebi.ac.uk/ena/data/view/AJ004856
EMBL	AK312890	http://www.ebi.ac.uk/ena/data/view/AK312890
EMBL	AL121988	http://www.ebi.ac.uk/ena/data/view/AL121988
EMBL	BC012918	http://www.ebi.ac.uk/ena/data/view/BC012918
EMBL	BC110640	http://www.ebi.ac.uk/ena/data/view/BC110640
EMBL	CH471059	http://www.ebi.ac.uk/ena/data/view/CH471059
Ensembl	ENST00000373362	http://www.ensembl.org/id/ENST00000373362
Ensembl	ENST00000373366	http://www.ensembl.org/id/ENST00000373366
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005921	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005921
GO_component	GO:0005922	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005922
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005243	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005243
GO_process	GO:0001701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001701
GO_process	GO:0001890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001890
GO_process	GO:0007154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007154
GO_process	GO:0007605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007605
GO_process	GO:0043588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043588
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009790
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	GJB3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GJB3
GeneID	2707	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2707
GeneTree	ENSGT00860000133694	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00860000133694
H-InvDB	HIX0000402	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0000402
HGNC	HGNC:4285	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4285
HOGENOM	HOG000231127	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231127&db=HOGENOM6
HOVERGEN	HBG009576	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG009576&db=HOVERGEN
HPA	CAB033241	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB033241
InParanoid	O75712	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O75712
IntAct	O75712	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O75712*
InterPro	IPR000500	http://www.ebi.ac.uk/interpro/entry/IPR000500
InterPro	IPR002269	http://www.ebi.ac.uk/interpro/entry/IPR002269
InterPro	IPR013092	http://www.ebi.ac.uk/interpro/entry/IPR013092
InterPro	IPR017990	http://www.ebi.ac.uk/interpro/entry/IPR017990
InterPro	IPR019570	http://www.ebi.ac.uk/interpro/entry/IPR019570
Jabion	2707	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2707
KEGG_Disease	H00604	http://www.genome.jp/dbget-bin/www_bget?H00604
KEGG_Disease	H00605	http://www.genome.jp/dbget-bin/www_bget?H00605
KEGG_Disease	H00710	http://www.genome.jp/dbget-bin/www_bget?H00710
KEGG_Gene	hsa:2707	http://www.genome.jp/dbget-bin/www_bget?hsa:2707
KEGG_Orthology	KO:K07622	http://www.genome.jp/dbget-bin/www_bget?KO:K07622
MIM	133200	http://www.ncbi.nlm.nih.gov/omim/133200
MIM	603324	http://www.ncbi.nlm.nih.gov/omim/603324
MIM	612644	http://www.ncbi.nlm.nih.gov/omim/612644
OMA	HTLWHGF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HTLWHGF
Orphanet	139512	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=139512
Orphanet	317	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=317
Orphanet	90635	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=90635
Orphanet	90636	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=90636
OrthoDB	EOG091G0FKH	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0FKH
PANTHER	PTHR11984	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11984
PANTHER	PTHR11984:SF65	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11984:SF65
PRINTS	PR00206	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00206
PRINTS	PR01140	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01140
PROSITE	PS00407	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00407
PROSITE	PS00408	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00408
PSORT	swissprot:CXB3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CXB3_HUMAN
PSORT-B	swissprot:CXB3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CXB3_HUMAN
PSORT2	swissprot:CXB3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CXB3_HUMAN
Pfam	PF00029	http://pfam.xfam.org/family/PF00029
PharmGKB	PA28696	http://www.pharmgkb.org/do/serve?objId=PA28696&objCls=Gene
Phobius	swissprot:CXB3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CXB3_HUMAN
PhylomeDB	O75712	http://phylomedb.org/?seqid=O75712
ProteinModelPortal	O75712	http://www.proteinmodelportal.org/query/uniprot/O75712
PubMed	10594760	http://www.ncbi.nlm.nih.gov/pubmed/10594760
PubMed	10757647	http://www.ncbi.nlm.nih.gov/pubmed/10757647
PubMed	10790215	http://www.ncbi.nlm.nih.gov/pubmed/10790215
PubMed	10798362	http://www.ncbi.nlm.nih.gov/pubmed/10798362
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	19283857	http://www.ncbi.nlm.nih.gov/pubmed/19283857
PubMed	9704026	http://www.ncbi.nlm.nih.gov/pubmed/9704026
PubMed	9843209	http://www.ncbi.nlm.nih.gov/pubmed/9843209
PubMed	9843210	http://www.ncbi.nlm.nih.gov/pubmed/9843210
Reactome	R-HSA-190861	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-190861
RefSeq	NP_001005752	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001005752
RefSeq	NP_076872	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_076872
SMART	SM00037	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00037
SMART	SM01089	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01089
SMR	O75712	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O75712
STRING	9606.ENSP00000362460	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000362460&targetmode=cogs
TCDB	1.A.24.1.10	http://www.tcdb.org/search/result.php?tc=1.A.24.1.10
UCSC	uc001bxx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001bxx&org=rat
UniGene	Hs.522561	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.522561
UniProtKB	CXB3_HUMAN	http://www.uniprot.org/uniprot/CXB3_HUMAN
UniProtKB-AC	O75712	http://www.uniprot.org/uniprot/O75712
charge	swissprot:CXB3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CXB3_HUMAN
eggNOG	ENOG410IE21	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IE21
eggNOG	ENOG410Y9C2	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y9C2
epestfind	swissprot:CXB3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CXB3_HUMAN
garnier	swissprot:CXB3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CXB3_HUMAN
helixturnhelix	swissprot:CXB3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CXB3_HUMAN
hmoment	swissprot:CXB3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CXB3_HUMAN
iep	swissprot:CXB3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CXB3_HUMAN
inforesidue	swissprot:CXB3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CXB3_HUMAN
neXtProt	NX_O75712	http://www.nextprot.org/db/entry/NX_O75712
octanol	swissprot:CXB3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CXB3_HUMAN
pepcoil	swissprot:CXB3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CXB3_HUMAN
pepdigest	swissprot:CXB3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CXB3_HUMAN
pepinfo	swissprot:CXB3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CXB3_HUMAN
pepnet	swissprot:CXB3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CXB3_HUMAN
pepstats	swissprot:CXB3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CXB3_HUMAN
pepwheel	swissprot:CXB3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CXB3_HUMAN
pepwindow	swissprot:CXB3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CXB3_HUMAN
sigcleave	swissprot:CXB3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CXB3_HUMAN
## Database	ID	URL or Descriptions
# AltName	LRC8E_HUMAN	Leucine-rich repeat-containing protein 8E
# BioGrid	123131	18
# Ensembl	ENST00000306708	ENSP00000306524; ENSG00000171017
# Ensembl	ENST00000618098	ENSP00000479953; ENSG00000171017
# ExpressionAtlas	Q6NSJ5	baseline and differential
# FUNCTION	LRC8E_HUMAN	Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. {ECO 0000269|PubMed 24790029, ECO 0000269|PubMed 26824658}. 
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005789	endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IMP:UniProtKB.
# GO_function	GO:0005225	volume-sensitive anion channel activity; IMP:UniProtKB.
# GO_process	GO:0098656	anion transmembrane transport; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.80.10.10	-; 3.
# Genevisible	Q6NSJ5	HS
# HGNC	HGNC:26272	LRRC8E
# INTERACTION	LRC8E_HUMAN	Q9C040 TRIM2; NbExp=3; IntAct=EBI-8647013, EBI-749840; 
# IntAct	Q6NSJ5	4
# InterPro	IPR001611	Leu-rich_rpt
# InterPro	IPR003591	Leu-rich_rpt_typical-subtyp
# InterPro	IPR021040	LRRC8_Pannexin-like
# InterPro	IPR032675	L_dom-like
# KEGG_Disease	H00085	[Primary immunodeficiency] Leucine-rich repeat-containing 8
# MIM	612891	gene
# Organism	LRC8E_HUMAN	Homo sapiens (Human)
# PROSITE	PS51450	LRR; 8
# Pfam	PF12534	Pannexin_like
# Pfam	PF13855	LRR_8; 2
# Proteomes	UP000005640	Chromosome 19
# RecName	LRC8E_HUMAN	Volume-regulated anion channel subunit LRRC8E
# RefSeq	NP_001255213	NM_001268284.2
# RefSeq	NP_001255214	NM_001268285.2
# RefSeq	NP_079337	NM_025061.5
# RefSeq	XP_011526621	XM_011528319.2
# SEQUENCE CAUTION	Sequence=BAB15648.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15648.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the LRRC8 family. {ECO	0000305}. 
# SIMILARITY	Contains 11 LRR (leucine-rich) repeats. {ECO	0000305}. 
# SMART	SM00369	LRR_TYP; 7
# SUBCELLULAR LOCATION	LRC8E_HUMAN	Cell membrane {ECO 0000269|PubMed 24790029}; Multi-pass membrane protein {ECO 0000305}. Endoplasmic reticulum membrane {ECO 0000305|PubMed 24790029}. Note=In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum. Requires LRRC8A for expression at the cell membrane. {ECO 0000269|PubMed 24790029}. 
# SUBUNIT	LRC8E_HUMAN	Heterooligomer; heterooligomerizes with other LRRC8 proteins (LRRC8A, LRRC8C, LRRC8D and/or LRRC8B), possibly to form a heterohexamer (PubMed 24790029, PubMed 26824658). In vivo, the subunit composition may depend primarily on expression levels, and heterooligomeric channels containing various proportions of the different LRRC8 proteins may coexist (Probable). {ECO 0000269|PubMed 24790029, ECO 0000269|PubMed 26824658, ECO 0000305}. 
# SUPFAM	SSF52058	SSF52058
# TCDB	1.A.25.3	the gap junction-forming innexin (innexin) family
# UCSC	uc002mir	human
# eggNOG	COG4886	LUCA
# eggNOG	KOG0619	Eukaryota
BLAST	swissprot:LRC8E_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:LRC8E_HUMAN
COXPRESdb	80131	http://coxpresdb.jp/data/gene/80131.shtml
CleanEx	HS_LRRC8E	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_LRRC8E
DIP	DIP-61363N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-61363N
DOI	10.1002/bies.201100173	http://dx.doi.org/10.1002/bies.201100173
DOI	10.1016/j.cell.2015.12.031	http://dx.doi.org/10.1016/j.cell.2015.12.031
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1252826	http://dx.doi.org/10.1126/science.1252826
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AC010336	http://www.ebi.ac.uk/ena/data/view/AC010336
EMBL	AK027073	http://www.ebi.ac.uk/ena/data/view/AK027073
EMBL	AK091134	http://www.ebi.ac.uk/ena/data/view/AK091134
EMBL	AL834474	http://www.ebi.ac.uk/ena/data/view/AL834474
EMBL	BC022216	http://www.ebi.ac.uk/ena/data/view/BC022216
EMBL	BC070089	http://www.ebi.ac.uk/ena/data/view/BC070089
EMBL	BC108252	http://www.ebi.ac.uk/ena/data/view/BC108252
EMBL	BX538180	http://www.ebi.ac.uk/ena/data/view/BX538180
EMBL	CH471139	http://www.ebi.ac.uk/ena/data/view/CH471139
Ensembl	ENST00000306708	http://www.ensembl.org/id/ENST00000306708
Ensembl	ENST00000618098	http://www.ensembl.org/id/ENST00000618098
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005225	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005225
GO_process	GO:0098656	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098656
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.80.10.10	http://www.cathdb.info/version/latest/superfamily/3.80.10.10
GeneCards	LRRC8E	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=LRRC8E
GeneID	80131	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80131
GeneTree	ENSGT00840000129676	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00840000129676
H-InvDB	HIX0202737	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0202737
HGNC	HGNC:26272	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:26272
HOGENOM	HOG000231806	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231806&db=HOGENOM6
HOVERGEN	HBG052360	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052360&db=HOVERGEN
HPA	HPA020466	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA020466
InParanoid	Q6NSJ5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6NSJ5
IntAct	Q6NSJ5	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q6NSJ5*
InterPro	IPR001611	http://www.ebi.ac.uk/interpro/entry/IPR001611
InterPro	IPR003591	http://www.ebi.ac.uk/interpro/entry/IPR003591
InterPro	IPR021040	http://www.ebi.ac.uk/interpro/entry/IPR021040
InterPro	IPR032675	http://www.ebi.ac.uk/interpro/entry/IPR032675
Jabion	80131	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=80131
KEGG_Disease	H00085	http://www.genome.jp/dbget-bin/www_bget?H00085
KEGG_Gene	hsa:80131	http://www.genome.jp/dbget-bin/www_bget?hsa:80131
MIM	612891	http://www.ncbi.nlm.nih.gov/omim/612891
OMA	FINQLCY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FINQLCY
OrthoDB	EOG091G01ER	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01ER
PROSITE	PS51450	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51450
PSORT	swissprot:LRC8E_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:LRC8E_HUMAN
PSORT-B	swissprot:LRC8E_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:LRC8E_HUMAN
PSORT2	swissprot:LRC8E_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:LRC8E_HUMAN
Pfam	PF12534	http://pfam.xfam.org/family/PF12534
Pfam	PF13855	http://pfam.xfam.org/family/PF13855
PharmGKB	PA142671537	http://www.pharmgkb.org/do/serve?objId=PA142671537&objCls=Gene
Phobius	swissprot:LRC8E_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:LRC8E_HUMAN
PhylomeDB	Q6NSJ5	http://phylomedb.org/?seqid=Q6NSJ5
ProteinModelPortal	Q6NSJ5	http://www.proteinmodelportal.org/query/uniprot/Q6NSJ5
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	22532330	http://www.ncbi.nlm.nih.gov/pubmed/22532330
PubMed	24790029	http://www.ncbi.nlm.nih.gov/pubmed/24790029
PubMed	26824658	http://www.ncbi.nlm.nih.gov/pubmed/26824658
RefSeq	NP_001255213	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001255213
RefSeq	NP_001255214	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001255214
RefSeq	NP_079337	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_079337
RefSeq	XP_011526621	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011526621
SMART	SM00369	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00369
STRING	9606.ENSP00000306524	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000306524&targetmode=cogs
SUPFAM	SSF52058	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52058
TCDB	1.A.25.3	http://www.tcdb.org/search/result.php?tc=1.A.25.3
UCSC	uc002mir	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002mir&org=rat
UniGene	Hs.501511	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.501511
UniProtKB	LRC8E_HUMAN	http://www.uniprot.org/uniprot/LRC8E_HUMAN
UniProtKB-AC	Q6NSJ5	http://www.uniprot.org/uniprot/Q6NSJ5
charge	swissprot:LRC8E_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:LRC8E_HUMAN
eggNOG	COG4886	http://eggnogapi.embl.de/nog_data/html/tree/COG4886
eggNOG	KOG0619	http://eggnogapi.embl.de/nog_data/html/tree/KOG0619
epestfind	swissprot:LRC8E_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:LRC8E_HUMAN
garnier	swissprot:LRC8E_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:LRC8E_HUMAN
helixturnhelix	swissprot:LRC8E_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:LRC8E_HUMAN
hmoment	swissprot:LRC8E_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:LRC8E_HUMAN
iep	swissprot:LRC8E_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:LRC8E_HUMAN
inforesidue	swissprot:LRC8E_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:LRC8E_HUMAN
neXtProt	NX_Q6NSJ5	http://www.nextprot.org/db/entry/NX_Q6NSJ5
octanol	swissprot:LRC8E_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:LRC8E_HUMAN
pepcoil	swissprot:LRC8E_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:LRC8E_HUMAN
pepdigest	swissprot:LRC8E_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:LRC8E_HUMAN
pepinfo	swissprot:LRC8E_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:LRC8E_HUMAN
pepnet	swissprot:LRC8E_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:LRC8E_HUMAN
pepstats	swissprot:LRC8E_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:LRC8E_HUMAN
pepwheel	swissprot:LRC8E_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:LRC8E_HUMAN
pepwindow	swissprot:LRC8E_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:LRC8E_HUMAN
sigcleave	swissprot:LRC8E_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:LRC8E_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ACHD_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q07001-1; Sequence=Displayed; Name=2; IsoId=Q07001-2; Sequence=VSP_046423; Note=No experimental confirmation available.; 
# BioGrid	107566	53
# CCDS	CCDS2494	-. [Q07001-1]
# CCDS	CCDS58754	-. [Q07001-2]
# DISEASE	ACHD_HUMAN	Multiple pterygium syndrome, lethal type (LMPS) [MIM 253290]  Multiple pterygia are found infrequently in children with arthrogryposis and in fetuses with fetal akinesia syndrome. In lethal multiple pterygium syndrome there is intrauterine growth retardation, multiple pterygia, and flexion contractures causing severe arthrogryposis and fetal akinesia. Subcutaneous edema can be severe, causing fetal hydrops with cystic hygroma and lung hypoplasia. Oligohydramnios and facial anomalies are frequent. {ECO 0000269|PubMed 18252226}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ACHD_HUMAN	Myasthenic syndrome, congenital, 3A, slow-channel (CMS3A) [MIM 616321]  A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. CMS3A is a slow-channel myasthenic syndrome. It is caused by kinetic abnormalities of the AChR, resulting in prolonged AChR channel opening episodes, prolonged endplate currents, and depolarization block. This is associated with calcium overload, which may contribute to subsequent degeneration of the endplate and postsynaptic membrane. {ECO 0000269|PubMed 11782989, ECO 0000269|PubMed 8872460}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ACHD_HUMAN	Myasthenic syndrome, congenital, 3B, fast-channel (CMS3B) [MIM 616322]  A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. CMS3B is a fast-channel myasthenic syndrome. It is caused by kinetic abnormalities of the AChR, resulting in brief opening and activity of the channel, with a rapid decay in endplate current, failure to achieve threshold depolarization of the endplate and consequent failure to fire an action potential. {ECO 0000269|PubMed 11435464, ECO 0000269|PubMed 12499478, ECO 0000269|PubMed 18398509}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ACHD_HUMAN	Myasthenic syndrome, congenital, 3C, associated with acetylcholine receptor deficiency (CMS3C) [MIM 616323]  A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. CMS3C is an autosomal recessive disorder of postsynaptic neuromuscular transmission, due to deficiency of AChR at the endplate that results in low amplitude of the miniature endplate potential and current. {ECO 0000269|PubMed 16916845, ECO 0000269|PubMed 18398509}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00674	Galantamine
# Ensembl	ENST00000258385	ENSP00000258385; ENSG00000135902. [Q07001-1]
# Ensembl	ENST00000543200	ENSP00000438380; ENSG00000135902. [Q07001-2]
# ExpressionAtlas	Q07001	baseline and differential
# FUNCTION	ACHD_HUMAN	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005892	acetylcholine-gated channel complex; TAS:ProtInc.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0045211	postsynaptic membrane; NAS:BHF-UCL.
# GO_function	GO:0004889	acetylcholine-activated cation-selective channel activity; TAS:ProtInc.
# GO_function	GO:0015276	ligand-gated ion channel activity; TAS:Reactome.
# GO_function	GO:0042166	acetylcholine binding; IEA:Ensembl.
# GO_process	GO:0003009	skeletal muscle contraction; IEA:Ensembl.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006936	muscle contraction; TAS:ProtInc.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0007271	synaptic transmission, cholinergic; IBA:GO_Central.
# GO_process	GO:0007274	neuromuscular synaptic transmission; IBA:GO_Central.
# GO_process	GO:0035094	response to nicotine; IBA:GO_Central.
# GO_process	GO:0042391	regulation of membrane potential; IEA:Ensembl.
# GO_process	GO:0048630	skeletal muscle tissue growth; IMP:BHF-UCL.
# GO_process	GO:0050881	musculoskeletal movement; IMP:BHF-UCL.
# GO_process	GO:0050905	neuromuscular process; NAS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0040007	growth
# GOslim_process	GO:0050877	neurological system process
# Gene3D	1.20.120.370	-; 2.
# Gene3D	2.70.170.10	-; 1.
# Genevisible	Q07001	HS
# HGNC	HGNC:1965	CHRND
# InterPro	IPR002394	Nicotinic_acetylcholine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# InterPro	IPR027361	Acetylcholine_rcpt_TM
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00770	[Nervous system disease] Congenital myasthenic syndrome
# KEGG_Disease	H00986	[Developmental disorder] Multiple pterygium syndrome, Escobar variant (EVMPS)
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# MIM	100720	gene
# MIM	253290	phenotype
# MIM	616321	phenotype
# MIM	616322	phenotype
# MIM	616323	phenotype
# Organism	ACHD_HUMAN	Homo sapiens (Human)
# Orphanet	33108	Lethal multiple pterygium syndrome
# Orphanet	98913	Postsynaptic congenital myasthenic syndromes
# PANTHER	PTHR18945	PTHR18945; 2
# PIR	A60916	A60916
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00254	NICOTINICR
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-629587	Highly sodium permeable acetylcholine nicotinic receptors
# RecName	ACHD_HUMAN	Acetylcholine receptor subunit delta
# RefSeq	NP_000742	NM_000751.2. [Q07001-1]
# RefSeq	NP_001243586	NM_001256657.1. [Q07001-2]
# RefSeq	NP_001298124	NM_001311195.1
# RefSeq	NP_001298125	NM_001311196.1
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Delta/CHRND sub-subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	ACHD_HUMAN	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	ACHD_HUMAN	Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TCDB	1.A.9.1	the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family
# TIGRFAMs	TIGR00860	LIC
# UCSC	uc002vsw	human. [Q07001-1]
# eggNOG	ENOG410XQGR	LUCA
# eggNOG	KOG3645	Eukaryota
BLAST	swissprot:ACHD_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ACHD_HUMAN
BioCyc	ZFISH:ENSG00000135902-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000135902-MONOMER
COXPRESdb	1144	http://coxpresdb.jp/data/gene/1144.shtml
CleanEx	HS_CHRND	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CHRND
DOI	10.1002/ana.10077	http://dx.doi.org/10.1002/ana.10077
DOI	10.1016/j.ajhg.2007.11.006	http://dx.doi.org/10.1016/j.ajhg.2007.11.006
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/brain/awl188	http://dx.doi.org/10.1093/brain/awl188
DOI	10.1093/hmg/5.9.1217	http://dx.doi.org/10.1093/hmg/5.9.1217
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1172/JCI200112935	http://dx.doi.org/10.1172/JCI200112935
DOI	10.1172/JCI34527	http://dx.doi.org/10.1172/JCI34527
DOI	10.1212/01.WNL.0000042422.87384.2F	http://dx.doi.org/10.1212/01.WNL.0000042422.87384.2F
DrugBank	DB00674	http://www.drugbank.ca/drugs/DB00674
EMBL	AC092165	http://www.ebi.ac.uk/ena/data/view/AC092165
EMBL	AK291526	http://www.ebi.ac.uk/ena/data/view/AK291526
EMBL	AK300109	http://www.ebi.ac.uk/ena/data/view/AK300109
EMBL	AK315297	http://www.ebi.ac.uk/ena/data/view/AK315297
EMBL	BC093923	http://www.ebi.ac.uk/ena/data/view/BC093923
EMBL	BC093925	http://www.ebi.ac.uk/ena/data/view/BC093925
EMBL	CH471063	http://www.ebi.ac.uk/ena/data/view/CH471063
EMBL	X55019	http://www.ebi.ac.uk/ena/data/view/X55019
Ensembl	ENST00000258385	http://www.ensembl.org/id/ENST00000258385
Ensembl	ENST00000543200	http://www.ensembl.org/id/ENST00000543200
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005892	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005892
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0004889	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004889
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_function	GO:0042166	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042166
GO_process	GO:0003009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003009
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006936	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006936
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007271
GO_process	GO:0007274	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007274
GO_process	GO:0035094	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035094
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0048630	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048630
GO_process	GO:0050881	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050881
GO_process	GO:0050905	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050905
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0040007	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040007
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
Gene3D	1.20.120.370	http://www.cathdb.info/version/latest/superfamily/1.20.120.370
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	CHRND	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CHRND
GeneID	1144	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1144
GeneTree	ENSGT00760000118930	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118930
HGNC	HGNC:1965	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1965
HOGENOM	HOG000006757	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006757&db=HOGENOM6
HOVERGEN	HBG003756	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003756&db=HOVERGEN
HPA	CAB000086	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB000086
HPA	CAB016303	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB016303
InParanoid	Q07001	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q07001
IntAct	Q07001	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q07001*
InterPro	IPR002394	http://www.ebi.ac.uk/interpro/entry/IPR002394
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
InterPro	IPR027361	http://www.ebi.ac.uk/interpro/entry/IPR027361
Jabion	1144	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1144
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00770	http://www.genome.jp/dbget-bin/www_bget?H00770
KEGG_Disease	H00986	http://www.genome.jp/dbget-bin/www_bget?H00986
KEGG_Gene	hsa:1144	http://www.genome.jp/dbget-bin/www_bget?hsa:1144
KEGG_Orthology	KO:K04816	http://www.genome.jp/dbget-bin/www_bget?KO:K04816
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
MIM	100720	http://www.ncbi.nlm.nih.gov/omim/100720
MIM	253290	http://www.ncbi.nlm.nih.gov/omim/253290
MIM	616321	http://www.ncbi.nlm.nih.gov/omim/616321
MIM	616322	http://www.ncbi.nlm.nih.gov/omim/616322
MIM	616323	http://www.ncbi.nlm.nih.gov/omim/616323
OMA	RLCLFLI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RLCLFLI
Orphanet	33108	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=33108
Orphanet	98913	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98913
OrthoDB	EOG091G0R20	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0R20
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00254	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00254
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:ACHD_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ACHD_HUMAN
PSORT-B	swissprot:ACHD_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ACHD_HUMAN
PSORT2	swissprot:ACHD_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ACHD_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA26497	http://www.pharmgkb.org/do/serve?objId=PA26497&objCls=Gene
Phobius	swissprot:ACHD_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ACHD_HUMAN
PhylomeDB	Q07001	http://phylomedb.org/?seqid=Q07001
ProteinModelPortal	Q07001	http://www.proteinmodelportal.org/query/uniprot/Q07001
PubMed	11435464	http://www.ncbi.nlm.nih.gov/pubmed/11435464
PubMed	11782989	http://www.ncbi.nlm.nih.gov/pubmed/11782989
PubMed	12499478	http://www.ncbi.nlm.nih.gov/pubmed/12499478
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	16916845	http://www.ncbi.nlm.nih.gov/pubmed/16916845
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	18252226	http://www.ncbi.nlm.nih.gov/pubmed/18252226
PubMed	18398509	http://www.ncbi.nlm.nih.gov/pubmed/18398509
PubMed	2564429	http://www.ncbi.nlm.nih.gov/pubmed/2564429
PubMed	8872460	http://www.ncbi.nlm.nih.gov/pubmed/8872460
Reactome	R-HSA-629587	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-629587
RefSeq	NP_000742	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000742
RefSeq	NP_001243586	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243586
RefSeq	NP_001298124	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001298124
RefSeq	NP_001298125	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001298125
STRING	9606.ENSP00000258385	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000258385&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TCDB	1.A.9.1	http://www.tcdb.org/search/result.php?tc=1.A.9.1
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc002vsw	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002vsw&org=rat
UniGene	Hs.156289	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.156289
UniProtKB	ACHD_HUMAN	http://www.uniprot.org/uniprot/ACHD_HUMAN
UniProtKB-AC	Q07001	http://www.uniprot.org/uniprot/Q07001
charge	swissprot:ACHD_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ACHD_HUMAN
eggNOG	ENOG410XQGR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQGR
eggNOG	KOG3645	http://eggnogapi.embl.de/nog_data/html/tree/KOG3645
epestfind	swissprot:ACHD_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ACHD_HUMAN
garnier	swissprot:ACHD_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ACHD_HUMAN
helixturnhelix	swissprot:ACHD_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACHD_HUMAN
hmoment	swissprot:ACHD_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ACHD_HUMAN
iep	swissprot:ACHD_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ACHD_HUMAN
inforesidue	swissprot:ACHD_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ACHD_HUMAN
neXtProt	NX_Q07001	http://www.nextprot.org/db/entry/NX_Q07001
octanol	swissprot:ACHD_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ACHD_HUMAN
pepcoil	swissprot:ACHD_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ACHD_HUMAN
pepdigest	swissprot:ACHD_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ACHD_HUMAN
pepinfo	swissprot:ACHD_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ACHD_HUMAN
pepnet	swissprot:ACHD_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ACHD_HUMAN
pepstats	swissprot:ACHD_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ACHD_HUMAN
pepwheel	swissprot:ACHD_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ACHD_HUMAN
pepwindow	swissprot:ACHD_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ACHD_HUMAN
sigcleave	swissprot:ACHD_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ACHD_HUMAN
## Database	ID	URL or Descriptions
# AltName	PM34_HUMAN	34 kDa peroxisomal membrane protein
# AltName	PM34_HUMAN	Solute carrier family 25 member 17
# BioGrid	115741	30
# CAUTION	PM34_HUMAN	Was first identified as a peroxisomal ATP transporter (PubMed 12445829). However, later experiments showed that it acts as a peroxisomal transporter for multiple cofactors (PubMed 22185573). {ECO 0000305|PubMed 12445829, ECO 0000305|PubMed 22185573}.
# DOMAIN	PM34_HUMAN	The N- and C-terminal portions are exposed to the cytoplasm. Lacks a typical peroxisomal sorting signal. A region between helical transmembrane domains (TM) 4 and 5 and TM1-TM3 or TM4-TM6 are necessary for the peroxisome-targeting activity. 
# Ensembl	ENST00000435456	ENSP00000390722; ENSG00000100372
# ExpressionAtlas	O43808	baseline and differential
# FUNCTION	PM34_HUMAN	Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extent for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3',5'- diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter- exchange mechanism. Inhibited by pyridoxal 5'-phosphate and bathophenanthroline in vitro. {ECO 0000269|PubMed 12445829, ECO 0000269|PubMed 22185573}. 
# GO_component	GO:0005739	mitochondrion; IEA:Ensembl.
# GO_component	GO:0005777	peroxisome; IDA:BHF-UCL.
# GO_component	GO:0005778	peroxisomal membrane; IDA:UniProtKB.
# GO_component	GO:0005779	integral component of peroxisomal membrane; IDA:UniProtKB.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_function	GO:0000295	adenine nucleotide transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0005347	ATP transmembrane transporter activity; IGI:BHF-UCL.
# GO_function	GO:0015217	ADP transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015228	coenzyme A transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015230	FAD transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0044610	FMN transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0051087	chaperone binding; IPI:BHF-UCL.
# GO_function	GO:0051724	NAD transporter activity; IDA:UniProtKB.
# GO_function	GO:0080122	AMP transmembrane transporter activity; IDA:UniProtKB.
# GO_process	GO:0001561	fatty acid alpha-oxidation; TAS:Reactome.
# GO_process	GO:0006635	fatty acid beta-oxidation; IGI:BHF-UCL.
# GO_process	GO:0015867	ATP transport; IGI:BHF-UCL.
# GO_process	GO:0015908	fatty acid transport; IGI:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005777	peroxisome
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0009056	catabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# Gene3D	1.50.40.10	-; 1.
# Genevisible	O43808	HS
# HGNC	HGNC:10987	SLC25A17
# INTERACTION	PM34_HUMAN	P40855 PEX19; NbExp=4; IntAct=EBI-594912, EBI-594747; 
# IntAct	O43808	3
# InterPro	IPR002067	Mit_carrier
# InterPro	IPR018108	Mitochondrial_sb/sol_carrier
# InterPro	IPR023395	Mt_carrier_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04146	Peroxisome
# MIM	606795	gene
# Organism	PM34_HUMAN	Homo sapiens (Human)
# PRINTS	PR00926	MITOCARRIER
# PROSITE	PS50920	SOLCAR; 3
# Pfam	PF00153	Mito_carr; 3
# Proteomes	UP000005640	Chromosome 22
# Reactome	R-HSA-389599	Alpha-oxidation of phytanate
# RecName	PM34_HUMAN	Peroxisomal membrane protein PMP34
# RefSeq	NP_001269656	NM_001282727.1
# RefSeq	NP_006349	NM_006358.3
# SIMILARITY	Belongs to the mitochondrial carrier (TC 2.A.29) family. {ECO	0000305}. 
# SIMILARITY	Contains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule	PRU00282}. 
# SUBCELLULAR LOCATION	PM34_HUMAN	Cytoplasm. Peroxisome membrane; Multi-pass membrane protein. 
# SUBUNIT	PM34_HUMAN	Interacts (via N- and C-terminus peroxisomal targeting regions) with PEX19; the interaction occurs with the newly synthesized SLC25A17 in the cytosol. {ECO 0000269|PubMed 10704444, ECO 0000269|PubMed 11402059, ECO 0000269|PubMed 14709540}. 
# SUPFAM	SSF103506	SSF103506
# TCDB	2.A.29.20	the mitochondrial carrier (mc) family
# TISSUE SPECIFICITY	Ubiquitous. Expressed in liver. {ECO:0000269|PubMed	22185573}. 
# UCSC	uc003azc	human
# eggNOG	ENOG410ZNC0	LUCA
# eggNOG	KOG0769	Eukaryota
BLAST	swissprot:PM34_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:PM34_HUMAN
BioCyc	ZFISH:ENSG00000100372-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000100372-MONOMER
COXPRESdb	10478	http://coxpresdb.jp/data/gene/10478.shtml
CleanEx	HS_SLC25A17	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC25A17
DOI	10.1016/S0006-291X(02)02663-3	http://dx.doi.org/10.1016/S0006-291X(02)02663-3
DOI	10.1038/990031	http://dx.doi.org/10.1038/990031
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/BJ20111420	http://dx.doi.org/10.1042/BJ20111420
DOI	10.1046/j.1432-1327.1998.2580332.x	http://dx.doi.org/10.1046/j.1432-1327.1998.2580332.x
DOI	10.1074/jbc.M003304200	http://dx.doi.org/10.1074/jbc.M003304200
DOI	10.1083/jcb.148.5.931	http://dx.doi.org/10.1083/jcb.148.5.931
DOI	10.1083/jcb.153.6.1141	http://dx.doi.org/10.1083/jcb.153.6.1141
DOI	10.1083/jcb.200304111	http://dx.doi.org/10.1083/jcb.200304111
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/gb-2004-5-10-r84	http://dx.doi.org/10.1186/gb-2004-5-10-r84
EMBL	AK292924	http://www.ebi.ac.uk/ena/data/view/AK292924
EMBL	AL049764	http://www.ebi.ac.uk/ena/data/view/AL049764
EMBL	AL049764	http://www.ebi.ac.uk/ena/data/view/AL049764
EMBL	BC005957	http://www.ebi.ac.uk/ena/data/view/BC005957
EMBL	BC012998	http://www.ebi.ac.uk/ena/data/view/BC012998
EMBL	CH471095	http://www.ebi.ac.uk/ena/data/view/CH471095
EMBL	CR456577	http://www.ebi.ac.uk/ena/data/view/CR456577
EMBL	Y12860	http://www.ebi.ac.uk/ena/data/view/Y12860
EMBL	Z98048	http://www.ebi.ac.uk/ena/data/view/Z98048
EMBL	Z98048	http://www.ebi.ac.uk/ena/data/view/Z98048
Ensembl	ENST00000435456	http://www.ensembl.org/id/ENST00000435456
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005777	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005777
GO_component	GO:0005778	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005778
GO_component	GO:0005779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005779
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0000295	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000295
GO_function	GO:0005347	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005347
GO_function	GO:0015217	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015217
GO_function	GO:0015228	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015228
GO_function	GO:0015230	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015230
GO_function	GO:0044610	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044610
GO_function	GO:0051087	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051087
GO_function	GO:0051724	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051724
GO_function	GO:0080122	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0080122
GO_process	GO:0001561	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001561
GO_process	GO:0006635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006635
GO_process	GO:0015867	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015867
GO_process	GO:0015908	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015908
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005777	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005777
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0009056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
Gene3D	1.50.40.10	http://www.cathdb.info/version/latest/superfamily/1.50.40.10
GeneCards	SLC25A17	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC25A17
GeneID	10478	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10478
GeneTree	ENSGT00770000120566	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00770000120566
HGNC	HGNC:10987	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10987
HOGENOM	HOG000159426	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000159426&db=HOGENOM6
HOVERGEN	HBG003235	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003235&db=HOVERGEN
HPA	HPA052708	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA052708
HPA	HPA060972	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA060972
InParanoid	O43808	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O43808
IntAct	O43808	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O43808*
InterPro	IPR002067	http://www.ebi.ac.uk/interpro/entry/IPR002067
InterPro	IPR018108	http://www.ebi.ac.uk/interpro/entry/IPR018108
InterPro	IPR023395	http://www.ebi.ac.uk/interpro/entry/IPR023395
Jabion	10478	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10478
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:10478	http://www.genome.jp/dbget-bin/www_bget?hsa:10478
KEGG_Orthology	KO:K13354	http://www.genome.jp/dbget-bin/www_bget?KO:K13354
KEGG_Pathway	ko04146	http://www.genome.jp/kegg-bin/show_pathway?ko04146
MIM	606795	http://www.ncbi.nlm.nih.gov/omim/606795
OMA	MGLKSAH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MGLKSAH
OrthoDB	EOG091G0DMQ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0DMQ
PRINTS	PR00926	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00926
PROSITE	PS50920	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50920
PSORT	swissprot:PM34_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:PM34_HUMAN
PSORT-B	swissprot:PM34_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:PM34_HUMAN
PSORT2	swissprot:PM34_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:PM34_HUMAN
Pfam	PF00153	http://pfam.xfam.org/family/PF00153
PharmGKB	PA35863	http://www.pharmgkb.org/do/serve?objId=PA35863&objCls=Gene
Phobius	swissprot:PM34_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:PM34_HUMAN
PhylomeDB	O43808	http://phylomedb.org/?seqid=O43808
ProteinModelPortal	O43808	http://www.proteinmodelportal.org/query/uniprot/O43808
PubMed	10591208	http://www.ncbi.nlm.nih.gov/pubmed/10591208
PubMed	10704444	http://www.ncbi.nlm.nih.gov/pubmed/10704444
PubMed	11121399	http://www.ncbi.nlm.nih.gov/pubmed/11121399
PubMed	11402059	http://www.ncbi.nlm.nih.gov/pubmed/11402059
PubMed	12445829	http://www.ncbi.nlm.nih.gov/pubmed/12445829
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	14709540	http://www.ncbi.nlm.nih.gov/pubmed/14709540
PubMed	15461802	http://www.ncbi.nlm.nih.gov/pubmed/15461802
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	22185573	http://www.ncbi.nlm.nih.gov/pubmed/22185573
PubMed	9874197	http://www.ncbi.nlm.nih.gov/pubmed/9874197
Reactome	R-HSA-389599	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-389599
RefSeq	NP_001269656	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269656
RefSeq	NP_006349	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006349
STRING	9606.ENSP00000390722	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000390722&targetmode=cogs
SUPFAM	SSF103506	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103506
TCDB	2.A.29.20	http://www.tcdb.org/search/result.php?tc=2.A.29.20
UCSC	uc003azc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003azc&org=rat
UniGene	Hs.474938	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.474938
UniProtKB	PM34_HUMAN	http://www.uniprot.org/uniprot/PM34_HUMAN
UniProtKB-AC	O43808	http://www.uniprot.org/uniprot/O43808
charge	swissprot:PM34_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:PM34_HUMAN
eggNOG	ENOG410ZNC0	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZNC0
eggNOG	KOG0769	http://eggnogapi.embl.de/nog_data/html/tree/KOG0769
epestfind	swissprot:PM34_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:PM34_HUMAN
garnier	swissprot:PM34_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:PM34_HUMAN
helixturnhelix	swissprot:PM34_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:PM34_HUMAN
hmoment	swissprot:PM34_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:PM34_HUMAN
iep	swissprot:PM34_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:PM34_HUMAN
inforesidue	swissprot:PM34_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:PM34_HUMAN
neXtProt	NX_O43808	http://www.nextprot.org/db/entry/NX_O43808
octanol	swissprot:PM34_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:PM34_HUMAN
pepcoil	swissprot:PM34_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:PM34_HUMAN
pepdigest	swissprot:PM34_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:PM34_HUMAN
pepinfo	swissprot:PM34_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:PM34_HUMAN
pepnet	swissprot:PM34_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:PM34_HUMAN
pepstats	swissprot:PM34_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:PM34_HUMAN
pepwheel	swissprot:PM34_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:PM34_HUMAN
pepwindow	swissprot:PM34_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:PM34_HUMAN
sigcleave	swissprot:PM34_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:PM34_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	120701	2
# CDD	cd06174	MFS
# ChiTaRS	SVOP	human
# Ensembl	ENST00000610966	ENSP00000479104; ENSG00000166111
# ExpressionAtlas	Q8N4V2	baseline and differential
# GO_component	GO:0008021	synaptic vesicle; ISS:HGNC.
# GO_component	GO:0016021	integral component of membrane; IBA:GO_Central.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030672	synaptic vesicle membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0022891	substrate-specific transmembrane transporter activity; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_function	GO:0022857	transmembrane transporter activity
# Genevisible	Q8N4V2	HS
# HGNC	HGNC:25417	SVOP
# InterPro	IPR004749	Orgcat_transp/SVOP
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# MIM	611699	gene
# Organism	SVOP_HUMAN	Homo sapiens (Human)
# PIR	T50622	T50622
# PROSITE	PS50850	MFS
# Pfam	PF00083	Sugar_tr
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 12
# RecName	SVOP_HUMAN	Synaptic vesicle 2-related protein
# RefSeq	NP_061181	NM_018711.4
# SIMILARITY	Belongs to the major facilitator superfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	SVOP_HUMAN	Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUPFAM	SSF103473	SSF103473
# TIGRFAMs	TIGR00898	2A0119
# UCSC	uc031zmo	human
# eggNOG	ENOG410ZVDQ	LUCA
# eggNOG	KOG0253	Eukaryota
# eggNOG	KOG0255	Eukaryota
BLAST	swissprot:SVOP_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SVOP_HUMAN
COXPRESdb	55530	http://coxpresdb.jp/data/gene/55530.shtml
CleanEx	HS_SVOP	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SVOP
DOI	10.1016/j.ygeno.2007.03.017	http://dx.doi.org/10.1016/j.ygeno.2007.03.017
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AL359592	http://www.ebi.ac.uk/ena/data/view/AL359592
EMBL	BC033587	http://www.ebi.ac.uk/ena/data/view/BC033587
EMBL	BC094722	http://www.ebi.ac.uk/ena/data/view/BC094722
Ensembl	ENST00000610966	http://www.ensembl.org/id/ENST00000610966
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0008021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008021
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030672	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030672
GO_function	GO:0022891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022891
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GeneCards	SVOP	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SVOP
GeneID	55530	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55530
GeneTree	ENSGT00550000074384	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074384
H-InvDB	HIX0021720	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0021720
HGNC	HGNC:25417	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:25417
HOGENOM	HOG000114543	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000114543&db=HOGENOM6
HOVERGEN	HBG057057	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG057057&db=HOVERGEN
HPA	HPA016573	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA016573
InParanoid	Q8N4V2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8N4V2
InterPro	IPR004749	http://www.ebi.ac.uk/interpro/entry/IPR004749
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	55530	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55530
KEGG_Gene	hsa:55530	http://www.genome.jp/dbget-bin/www_bget?hsa:55530
MIM	611699	http://www.ncbi.nlm.nih.gov/omim/611699
OMA	KEDYMDL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KEDYMDL
OrthoDB	EOG091G04VD	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G04VD
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:SVOP_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SVOP_HUMAN
PSORT-B	swissprot:SVOP_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SVOP_HUMAN
PSORT2	swissprot:SVOP_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SVOP_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA142670848	http://www.pharmgkb.org/do/serve?objId=PA142670848&objCls=Gene
Phobius	swissprot:SVOP_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SVOP_HUMAN
PhylomeDB	Q8N4V2	http://phylomedb.org/?seqid=Q8N4V2
ProteinModelPortal	Q8N4V2	http://www.proteinmodelportal.org/query/uniprot/Q8N4V2
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17714910	http://www.ncbi.nlm.nih.gov/pubmed/17714910
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
RefSeq	NP_061181	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061181
STRING	9606.ENSP00000299134	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000299134&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TIGRFAMs	TIGR00898	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00898
UCSC	uc031zmo	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc031zmo&org=rat
UniGene	Hs.27226	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.27226
UniGene	Hs.4221	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.4221
UniGene	Hs.595078	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.595078
UniProtKB	SVOP_HUMAN	http://www.uniprot.org/uniprot/SVOP_HUMAN
UniProtKB-AC	Q8N4V2	http://www.uniprot.org/uniprot/Q8N4V2
charge	swissprot:SVOP_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SVOP_HUMAN
eggNOG	ENOG410ZVDQ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZVDQ
eggNOG	KOG0253	http://eggnogapi.embl.de/nog_data/html/tree/KOG0253
eggNOG	KOG0255	http://eggnogapi.embl.de/nog_data/html/tree/KOG0255
epestfind	swissprot:SVOP_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SVOP_HUMAN
garnier	swissprot:SVOP_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SVOP_HUMAN
helixturnhelix	swissprot:SVOP_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SVOP_HUMAN
hmoment	swissprot:SVOP_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SVOP_HUMAN
iep	swissprot:SVOP_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SVOP_HUMAN
inforesidue	swissprot:SVOP_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SVOP_HUMAN
neXtProt	NX_Q8N4V2	http://www.nextprot.org/db/entry/NX_Q8N4V2
octanol	swissprot:SVOP_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SVOP_HUMAN
pepcoil	swissprot:SVOP_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SVOP_HUMAN
pepdigest	swissprot:SVOP_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SVOP_HUMAN
pepinfo	swissprot:SVOP_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SVOP_HUMAN
pepnet	swissprot:SVOP_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SVOP_HUMAN
pepstats	swissprot:SVOP_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SVOP_HUMAN
pepwheel	swissprot:SVOP_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SVOP_HUMAN
pepwindow	swissprot:SVOP_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SVOP_HUMAN
sigcleave	swissprot:SVOP_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SVOP_HUMAN
## Database	ID	URL or Descriptions
# Ensembl	ENST00000476166	ENSP00000473361; ENSG00000150201
# Ensembl	ENST00000616495	ENSP00000483791; ENSG00000150201
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0005267	potassium channel activity; IEA:Ensembl.
# GO_function	GO:0017080	sodium channel regulator activity; IBA:GO_Central.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GO_process	GO:2000649	regulation of sodium ion transmembrane transporter activity; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P59646	HS
# HGNC	HGNC:4028	FXYD4
# InterPro	IPR000272	Ion-transport_regulator_FXYD
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko04960	Aldosterone-regulated sodium reabsorption
# Organism	FXYD4_HUMAN	Homo sapiens (Human)
# PROSITE	PS01310	FXYD
# Pfam	PF02038	ATP1G1_PLM_MAT8
# Proteomes	UP000005640	Chromosome 10
# Reactome	R-HSA-5578775	Ion homeostasis
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	FXYD4_HUMAN	FXYD domain-containing ion transport regulator 4
# RefSeq	NP_001171892	NM_001184963.1
# RefSeq	NP_775183	NM_173160.2
# SIMILARITY	Belongs to the FXYD family. {ECO	0000305}.
# SUBCELLULAR LOCATION	FXYD4_HUMAN	Membrane {ECO 0000305}; Single-pass type I membrane protein {ECO 0000305}. 
# UCSC	uc001jaq	human
# eggNOG	ENOG410J4PQ	Eukaryota
# eggNOG	ENOG4111AWX	LUCA
BLAST	swissprot:FXYD4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:FXYD4_HUMAN
COXPRESdb	53828	http://coxpresdb.jp/data/gene/53828.shtml
CleanEx	HS_FXYD4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_FXYD4
DOI	10.1006/geno.2000.6274	http://dx.doi.org/10.1006/geno.2000.6274
DOI	10.1038/nature02462	http://dx.doi.org/10.1038/nature02462
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AL512654	http://www.ebi.ac.uk/ena/data/view/AL512654
EMBL	AY358584	http://www.ebi.ac.uk/ena/data/view/AY358584
EMBL	BC054876	http://www.ebi.ac.uk/ena/data/view/BC054876
Ensembl	ENST00000476166	http://www.ensembl.org/id/ENST00000476166
Ensembl	ENST00000616495	http://www.ensembl.org/id/ENST00000616495
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_function	GO:0017080	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017080
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GO_process	GO:2000649	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000649
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	FXYD4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=FXYD4
GeneID	53828	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=53828
GeneTree	ENSGT00530000063998	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063998
HGNC	HGNC:4028	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4028
HOGENOM	HOG000234469	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234469&db=HOGENOM6
HPA	HPA058421	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA058421
InParanoid	P59646	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P59646
InterPro	IPR000272	http://www.ebi.ac.uk/interpro/entry/IPR000272
Jabion	53828	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=53828
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:53828	http://www.genome.jp/dbget-bin/www_bget?hsa:53828
KEGG_Orthology	KO:K13359	http://www.genome.jp/dbget-bin/www_bget?KO:K13359
KEGG_Pathway	ko04960	http://www.genome.jp/kegg-bin/show_pathway?ko04960
OMA	PGSASTC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PGSASTC
PROSITE	PS01310	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01310
PSORT	swissprot:FXYD4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:FXYD4_HUMAN
PSORT-B	swissprot:FXYD4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:FXYD4_HUMAN
PSORT2	swissprot:FXYD4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:FXYD4_HUMAN
Pfam	PF02038	http://pfam.xfam.org/family/PF02038
PharmGKB	PA28444	http://www.pharmgkb.org/do/serve?objId=PA28444&objCls=Gene
Phobius	swissprot:FXYD4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:FXYD4_HUMAN
PhylomeDB	P59646	http://phylomedb.org/?seqid=P59646
ProteinModelPortal	P59646	http://www.proteinmodelportal.org/query/uniprot/P59646
PubMed	10950925	http://www.ncbi.nlm.nih.gov/pubmed/10950925
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	15164054	http://www.ncbi.nlm.nih.gov/pubmed/15164054
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_001171892	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001171892
RefSeq	NP_775183	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_775183
SMR	P59646	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P59646
STRING	9606.ENSP00000363575	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000363575&targetmode=cogs
UCSC	uc001jaq	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001jaq&org=rat
UniGene	Hs.130497	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.130497
UniProtKB	FXYD4_HUMAN	http://www.uniprot.org/uniprot/FXYD4_HUMAN
UniProtKB-AC	P59646	http://www.uniprot.org/uniprot/P59646
charge	swissprot:FXYD4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:FXYD4_HUMAN
eggNOG	ENOG410J4PQ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410J4PQ
eggNOG	ENOG4111AWX	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111AWX
epestfind	swissprot:FXYD4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:FXYD4_HUMAN
garnier	swissprot:FXYD4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:FXYD4_HUMAN
helixturnhelix	swissprot:FXYD4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:FXYD4_HUMAN
hmoment	swissprot:FXYD4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:FXYD4_HUMAN
iep	swissprot:FXYD4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:FXYD4_HUMAN
inforesidue	swissprot:FXYD4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:FXYD4_HUMAN
neXtProt	NX_P59646	http://www.nextprot.org/db/entry/NX_P59646
octanol	swissprot:FXYD4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:FXYD4_HUMAN
pepcoil	swissprot:FXYD4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:FXYD4_HUMAN
pepdigest	swissprot:FXYD4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:FXYD4_HUMAN
pepinfo	swissprot:FXYD4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:FXYD4_HUMAN
pepnet	swissprot:FXYD4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:FXYD4_HUMAN
pepstats	swissprot:FXYD4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:FXYD4_HUMAN
pepwheel	swissprot:FXYD4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:FXYD4_HUMAN
pepwindow	swissprot:FXYD4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:FXYD4_HUMAN
sigcleave	swissprot:FXYD4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:FXYD4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=7; Comment=May be partially controlled by hormonal stress. Additional isoforms seem to exist.; Name=1; Synonyms=SAKCA; IsoId=Q12791-1; Sequence=Displayed; Name=2; Synonyms=BKTM; IsoId=Q12791-2; Sequence=VSP_009955, VSP_009958; Name=3; IsoId=Q12791-3; Sequence=VSP_009954; Name=4; Synonyms=hbr5; IsoId=Q12791-4; Sequence=VSP_009956; Name=5; IsoId=Q12791-5; Sequence=VSP_009955; Name=6; IsoId=Q12791-6; Sequence=VSP_009952, VSP_009953; Note=No experimental confirmation available.; Name=7; Synonyms=gBK; IsoId=Q12791-7; Sequence=VSP_009957; Note=Ref.13 (no nucleotide entry) sequence is in conflict in positions: 726	FS->SF. {ECO:0000305}; 
# AltName	KCMA1_HUMAN	BK channel
# AltName	KCMA1_HUMAN	BKCA alpha
# AltName	KCMA1_HUMAN	Calcium-activated potassium channel, subfamily M subunit alpha-1
# AltName	KCMA1_HUMAN	K(VCA)alpha
# AltName	KCMA1_HUMAN	KCa1.1
# AltName	KCMA1_HUMAN	Maxi K channel
# AltName	KCMA1_HUMAN	Slo-alpha
# AltName	KCMA1_HUMAN	Slo1
# AltName	KCMA1_HUMAN	Slowpoke homolog
# BioGrid	109979	10
# CCDS	CCDS53545	-. [Q12791-2]
# CCDS	CCDS60569	-. [Q12791-1]
# CCDS	CCDS60571	-. [Q12791-6]
# CCDS	CCDS7352	-. [Q12791-5]
# ChiTaRS	KCNMA1	human
# DISEASE	KCMA1_HUMAN	Generalized epilepsy and paroxysmal dyskinesia (GEPD) [MIM 609446]  Epilepsy is one of the most common and debilitating neurological disorders. Paroxysmal dyskinesias are neurological disorders characterized by sudden, unpredictable, disabling attacks of involuntary movement often requiring life-long treatment. The coexistence of epilepsy and paroxysmal dyskinesia in the same individual or family is an increasingly recognized phenomenon. Patients manifest absence seizures, generalized tonic- clonic seizures, paroxysmal nonkinesigenic dyskinesia, involuntary dystonic or choreiform movements. Onset is usually in childhood and patients may have seizures only, dyskinesia only, or both. {ECO 0000269|PubMed 15937479}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	KCMA1_HUMAN	The RCK N-terminal domain mediates the homotetramerization, thereby promoting the assembly of monomers into functional potassium channel. It includes binding sites for Ca(2+) and Mg(2+) (By similarity). {ECO 0000250}. 
# DOMAIN	KCMA1_HUMAN	The S0 segment is essential for the modulation by the accessory beta subunits KCNMB1, KCNMB2, KCNMB3 and KCNMB4. 
# DOMAIN	KCMA1_HUMAN	The S4 segment, which is characterized by a series of positively charged amino acids at every third position, is part of the voltage-sensor. 
# DOMAIN	KCMA1_HUMAN	The calcium bowl constitutes one of the Ca(2+) sensors and probably acts as a Ca(2+)-binding site. There are however other Ca(2+) sensors regions required for activation of the channel. 
# DOMAIN	KCMA1_HUMAN	The heme-binding motif mediates inhibition of channel activation by heme. Carbon monoxide-bound heme leads to increased channel activation. 
# DOMAIN	KCMA1_HUMAN	The pore-forming domain (also referred as P region) is imbedded into the membrane, and forms the selectivity filter of the pore. It contains the signature sequence of potassium channels that displays selectivity to potassium. 
# DrugBank	DB00356	Chlorzoxazone
# DrugBank	DB00436	Bendroflumethiazide
# DrugBank	DB00721	Procaine
# DrugBank	DB00774	Hydroflumethiazide
# DrugBank	DB00999	Hydrochlorothiazide
# DrugBank	DB01003	Cromoglicic acid
# DrugBank	DB01110	Miconazole
# DrugBank	DB01119	Diazoxide
# DrugBank	DB01159	Halothane
# ENZYME REGULATION	Ethanol and carbon monoxide-bound heme increase channel activation. Heme inhibits channel activation. {ECO:0000269|PubMed	14523450}. 
# Ensembl	ENST00000286627	ENSP00000286627; ENSG00000156113. [Q12791-5]
# Ensembl	ENST00000286628	ENSP00000286628; ENSG00000156113. [Q12791-1]
# Ensembl	ENST00000480683	ENSP00000474686; ENSG00000156113. [Q12791-6]
# Ensembl	ENST00000626620	ENSP00000485867; ENSG00000156113. [Q12791-2]
# ExpressionAtlas	Q12791	baseline and differential
# FUNCTION	KCMA1_HUMAN	Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX). 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005901	caveola; IDA:BHF-UCL.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IDA:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0003779	actin binding; IDA:BHF-UCL.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IDA:UniProtKB.
# GO_function	GO:0015269	calcium-activated potassium channel activity; IDA:UniProtKB.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_function	GO:0060072	large conductance calcium-activated potassium channel activity; IDA:UniProtKB.
# GO_process	GO:0001666	response to hypoxia; IDA:UniProtKB.
# GO_process	GO:0006813	potassium ion transport; IDA:UniProtKB.
# GO_process	GO:0006970	response to osmotic stress; IDA:UniProtKB.
# GO_process	GO:0030007	cellular potassium ion homeostasis; IDA:UniProtKB.
# GO_process	GO:0034465	response to carbon monoxide; IDA:UniProtKB.
# GO_process	GO:0042391	regulation of membrane potential; IDA:UniProtKB.
# GO_process	GO:0043065	positive regulation of apoptotic process; IMP:UniProtKB.
# GO_process	GO:0045794	negative regulation of cell volume; IDA:UniProtKB.
# GO_process	GO:0051592	response to calcium ion; IDA:UniProtKB.
# GO_process	GO:0060073	micturition; IDA:UniProtKB.
# GO_process	GO:0060083	smooth muscle contraction involved in micturition; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0008092	cytoskeletal protein binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# Gene3D	3.40.50.720	-; 3.
# Genevisible	Q12791	HS
# HGNC	HGNC:6284	KCNMA1
# IntAct	Q12791	2
# InterPro	IPR003929	K_chnl_Ca-activ_BK_asu
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR016040	NAD(P)-bd_dom
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H01258	[Nervous system disease; Epilepsy] Generalized epilepsy and paroxysmal dyskinesia (GEPD)
# KEGG_Pathway	ko04270	Vascular smooth muscle contraction
# KEGG_Pathway	ko04970	Salivary secretion
# KEGG_Pathway	ko04972	Pancreatic secretion
# MIM	600150	gene
# MIM	609446	phenotype
# MISCELLANEOUS	The protein was initially thought to contain two functionally distinct parts	 The core channel (from the N-terminus to the S9 segment) that mediates the channel activity, and the cytoplasmic tail (from the S9 segment to the C-terminus) that mediates the calcium sensing. The situation is however more complex, since the core channel also contains binding sites for Ca(2+) and Mg(2+). 
# Organism	KCMA1_HUMAN	Homo sapiens (Human)
# Orphanet	79137	Generalized epilepsy - paroxysmal dyskinesia
# PDB	2K44	NMR; -; A=257-284
# PDB	3MT5	X-ray; 3.00 A; A=406-1179
# PDB	3NAF	X-ray; 3.10 A; A=395-681, A=782-1182
# PIR	I38596	I38596
# PIR	S62904	S62904
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01449	BKCHANNELA
# PTM	KCMA1_HUMAN	Palmitoylation by ZDHHC22 and ZDHHC23 within the intracellular linker between the S0 and S1 transmembrane domains regulates localization to the plasma membrane. Depalmitoylated by LYPLA1 and LYPLAL1, leading to retard exit from the trans-Golgi network. {ECO 0000269|PubMed 20693285, ECO 0000269|PubMed 22399288}. 
# PTM	KCMA1_HUMAN	Phosphorylated (Probable). Phosphorylation by kinases such as PKA and/or PKG. In smooth muscles, phosphorylation affects its activity. {ECO 0000305}. 
# Pfam	PF00520	Ion_trans
# Pfam	PF03493	BK_channel_a
# Proteomes	UP000005640	Chromosome 10
# Reactome	R-HSA-1296052	Ca2+ activated K+ channels
# Reactome	R-HSA-418457	cGMP effects
# RecName	KCMA1_HUMAN	Calcium-activated potassium channel subunit alpha-1
# RefSeq	NP_001014797	NM_001014797.2
# RefSeq	NP_001154824	NM_001161352.1. [Q12791-1]
# RefSeq	NP_001154825	NM_001161353.1. [Q12791-2]
# RefSeq	NP_001258447	NM_001271518.1
# RefSeq	NP_001258451	NM_001271522.1. [Q12791-6]
# RefSeq	NP_002238	NM_002247.3. [Q12791-5]
# SEQUENCE CAUTION	KCMA1_HUMAN	Sequence=AAA50216.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO 0000305}; Sequence=AAB65837.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=AAC50353.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=AAK91504.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=BAD06365.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305};
# SIMILARITY	Belongs to the potassium channel family. Calcium- activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 RCK N-terminal domain. {ECO	0000305}. 
# SUBCELLULAR LOCATION	KCMA1_HUMAN	Cell membrane {ECO 0000269|PubMed 20693285, ECO 0000269|PubMed 22399288}; Multi-pass membrane protein {ECO 0000269|PubMed 20693285, ECO 0000269|PubMed 22399288}. 
# SUBUNIT	KCMA1_HUMAN	Homotetramer; which constitutes the calcium-activated potassium channel. Interacts with RAB11B (By similarity). Interacts with beta subunits KCNMB1, KCNMB2, KCNMB3 and KCNMB4. Interacts with gamma subunits LRRC26, LRRC38, LRRC52 and LRRC55. Beta and gamma subunits are accessory, and modulate its activity. {ECO 0000250, ECO 0000269|PubMed 10097176, ECO 0000269|PubMed 10692449, ECO 0000269|PubMed 11880485, ECO 0000269|PubMed 20508092, ECO 0000269|PubMed 20613726, ECO 0000269|PubMed 22547800}. 
# SUPFAM	SSF51735	SSF51735
# TISSUE SPECIFICITY	Widely expressed. Except in myocytes, it is almost ubiquitously expressed. {ECO:0000269|PubMed	11880513}. 
# UCSC	uc001jxm	human. [Q12791-1]
BLAST	swissprot:KCMA1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCMA1_HUMAN
COXPRESdb	3778	http://coxpresdb.jp/data/gene/3778.shtml
DIP	DIP-29729N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29729N
DOI	10.1016/0169-328X(94)90203-8	http://dx.doi.org/10.1016/0169-328X(94)90203-8
DOI	10.1016/0896-6273(94)90418-9	http://dx.doi.org/10.1016/0896-6273(94)90418-9
DOI	10.1016/S0896-6273(01)00444-5	http://dx.doi.org/10.1016/S0896-6273(01)00444-5
DOI	10.1038/nature02003	http://dx.doi.org/10.1038/nature02003
DOI	10.1038/nature02462	http://dx.doi.org/10.1038/nature02462
DOI	10.1038/nature09162	http://dx.doi.org/10.1038/nature09162
DOI	10.1038/ng1585	http://dx.doi.org/10.1038/ng1585
DOI	10.1073/pnas.1205435109	http://dx.doi.org/10.1073/pnas.1205435109
DOI	10.1073/pnas.93.25.14922	http://dx.doi.org/10.1073/pnas.93.25.14922
DOI	10.1073/pnas.94.25.14066	http://dx.doi.org/10.1073/pnas.94.25.14066
DOI	10.1073/pnas.96.7.4137	http://dx.doi.org/10.1073/pnas.96.7.4137
DOI	10.1074/jbc.273.49.32430	http://dx.doi.org/10.1074/jbc.273.49.32430
DOI	10.1074/jbc.275.9.6453	http://dx.doi.org/10.1074/jbc.275.9.6453
DOI	10.1074/jbc.M110.153940	http://dx.doi.org/10.1074/jbc.M110.153940
DOI	10.1074/jbc.M111.335547	http://dx.doi.org/10.1074/jbc.M111.335547
DOI	10.1085/jgp.20028721	http://dx.doi.org/10.1085/jgp.20028721
DOI	10.1093/hmg/3.8.1239	http://dx.doi.org/10.1093/hmg/3.8.1239
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1124/jpet.110.166017	http://dx.doi.org/10.1124/jpet.110.166017
DOI	10.1126/science.1190414	http://dx.doi.org/10.1126/science.1190414
DrugBank	DB00356	http://www.drugbank.ca/drugs/DB00356
DrugBank	DB00436	http://www.drugbank.ca/drugs/DB00436
DrugBank	DB00721	http://www.drugbank.ca/drugs/DB00721
DrugBank	DB00774	http://www.drugbank.ca/drugs/DB00774
DrugBank	DB00999	http://www.drugbank.ca/drugs/DB00999
DrugBank	DB01003	http://www.drugbank.ca/drugs/DB01003
DrugBank	DB01110	http://www.drugbank.ca/drugs/DB01110
DrugBank	DB01119	http://www.drugbank.ca/drugs/DB01119
DrugBank	DB01159	http://www.drugbank.ca/drugs/DB01159
EMBL	AB113382	http://www.ebi.ac.uk/ena/data/view/AB113382
EMBL	AB113575	http://www.ebi.ac.uk/ena/data/view/AB113575
EMBL	AC011439	http://www.ebi.ac.uk/ena/data/view/AC011439
EMBL	AC011439	http://www.ebi.ac.uk/ena/data/view/AC011439
EMBL	AC011439	http://www.ebi.ac.uk/ena/data/view/AC011439
EMBL	AC011439	http://www.ebi.ac.uk/ena/data/view/AC011439
EMBL	AC011439	http://www.ebi.ac.uk/ena/data/view/AC011439
EMBL	AC011439	http://www.ebi.ac.uk/ena/data/view/AC011439
EMBL	AC011439	http://www.ebi.ac.uk/ena/data/view/AC011439
EMBL	AC011439	http://www.ebi.ac.uk/ena/data/view/AC011439
EMBL	AC021032	http://www.ebi.ac.uk/ena/data/view/AC021032
EMBL	AC021032	http://www.ebi.ac.uk/ena/data/view/AC021032
EMBL	AC021032	http://www.ebi.ac.uk/ena/data/view/AC021032
EMBL	AC021032	http://www.ebi.ac.uk/ena/data/view/AC021032
EMBL	AC021032	http://www.ebi.ac.uk/ena/data/view/AC021032
EMBL	AC021032	http://www.ebi.ac.uk/ena/data/view/AC021032
EMBL	AC021032	http://www.ebi.ac.uk/ena/data/view/AC021032
EMBL	AC021032	http://www.ebi.ac.uk/ena/data/view/AC021032
EMBL	AC067745	http://www.ebi.ac.uk/ena/data/view/AC067745
EMBL	AF025999	http://www.ebi.ac.uk/ena/data/view/AF025999
EMBL	AF118141	http://www.ebi.ac.uk/ena/data/view/AF118141
EMBL	AL157833	http://www.ebi.ac.uk/ena/data/view/AL157833
EMBL	AL157833	http://www.ebi.ac.uk/ena/data/view/AL157833
EMBL	AL157833	http://www.ebi.ac.uk/ena/data/view/AL157833
EMBL	AL157833	http://www.ebi.ac.uk/ena/data/view/AL157833
EMBL	AL157833	http://www.ebi.ac.uk/ena/data/view/AL157833
EMBL	AL157833	http://www.ebi.ac.uk/ena/data/view/AL157833
EMBL	AL157833	http://www.ebi.ac.uk/ena/data/view/AL157833
EMBL	AL157833	http://www.ebi.ac.uk/ena/data/view/AL157833
EMBL	AL607069	http://www.ebi.ac.uk/ena/data/view/AL607069
EMBL	AL627447	http://www.ebi.ac.uk/ena/data/view/AL627447
EMBL	AL627447	http://www.ebi.ac.uk/ena/data/view/AL627447
EMBL	AL627447	http://www.ebi.ac.uk/ena/data/view/AL627447
EMBL	AL627447	http://www.ebi.ac.uk/ena/data/view/AL627447
EMBL	AL627447	http://www.ebi.ac.uk/ena/data/view/AL627447
EMBL	AL627447	http://www.ebi.ac.uk/ena/data/view/AL627447
EMBL	AL627447	http://www.ebi.ac.uk/ena/data/view/AL627447
EMBL	AL627447	http://www.ebi.ac.uk/ena/data/view/AL627447
EMBL	AL731556	http://www.ebi.ac.uk/ena/data/view/AL731556
EMBL	AL731556	http://www.ebi.ac.uk/ena/data/view/AL731556
EMBL	AL731556	http://www.ebi.ac.uk/ena/data/view/AL731556
EMBL	AL731556	http://www.ebi.ac.uk/ena/data/view/AL731556
EMBL	AL731556	http://www.ebi.ac.uk/ena/data/view/AL731556
EMBL	AL731556	http://www.ebi.ac.uk/ena/data/view/AL731556
EMBL	AL731556	http://www.ebi.ac.uk/ena/data/view/AL731556
EMBL	AL731556	http://www.ebi.ac.uk/ena/data/view/AL731556
EMBL	AL731560	http://www.ebi.ac.uk/ena/data/view/AL731560
EMBL	AL731560	http://www.ebi.ac.uk/ena/data/view/AL731560
EMBL	AL731560	http://www.ebi.ac.uk/ena/data/view/AL731560
EMBL	AL731560	http://www.ebi.ac.uk/ena/data/view/AL731560
EMBL	AL731560	http://www.ebi.ac.uk/ena/data/view/AL731560
EMBL	AL731560	http://www.ebi.ac.uk/ena/data/view/AL731560
EMBL	AL731560	http://www.ebi.ac.uk/ena/data/view/AL731560
EMBL	AL731560	http://www.ebi.ac.uk/ena/data/view/AL731560
EMBL	AL731575	http://www.ebi.ac.uk/ena/data/view/AL731575
EMBL	AY040849	http://www.ebi.ac.uk/ena/data/view/AY040849
EMBL	BC062659	http://www.ebi.ac.uk/ena/data/view/BC062659
EMBL	BC137115	http://www.ebi.ac.uk/ena/data/view/BC137115
EMBL	BC137137	http://www.ebi.ac.uk/ena/data/view/BC137137
EMBL	CH471083	http://www.ebi.ac.uk/ena/data/view/CH471083
EMBL	U02632	http://www.ebi.ac.uk/ena/data/view/U02632
EMBL	U09384	http://www.ebi.ac.uk/ena/data/view/U09384
EMBL	U11058	http://www.ebi.ac.uk/ena/data/view/U11058
EMBL	U11717	http://www.ebi.ac.uk/ena/data/view/U11717
EMBL	U13913	http://www.ebi.ac.uk/ena/data/view/U13913
EMBL	U23767	http://www.ebi.ac.uk/ena/data/view/U23767
Ensembl	ENST00000286627	http://www.ensembl.org/id/ENST00000286627
Ensembl	ENST00000286628	http://www.ensembl.org/id/ENST00000286628
Ensembl	ENST00000480683	http://www.ensembl.org/id/ENST00000480683
Ensembl	ENST00000626620	http://www.ensembl.org/id/ENST00000626620
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005901
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0003779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003779
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0015269	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015269
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_function	GO:0060072	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060072
GO_process	GO:0001666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001666
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0006970	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006970
GO_process	GO:0030007	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030007
GO_process	GO:0034465	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034465
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0043065	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043065
GO_process	GO:0045794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045794
GO_process	GO:0051592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051592
GO_process	GO:0060073	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060073
GO_process	GO:0060083	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060083
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0008092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
Gene3D	3.40.50.720	http://www.cathdb.info/version/latest/superfamily/3.40.50.720
GeneCards	KCNMA1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNMA1
GeneID	3778	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3778
GeneTree	ENSGT00530000063026	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063026
HGNC	HGNC:6284	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6284
HOVERGEN	HBG052222	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052222&db=HOVERGEN
HPA	HPA054648	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA054648
HPA	HPA057838	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA057838
InParanoid	Q12791	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q12791
IntAct	Q12791	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q12791*
InterPro	IPR003929	http://www.ebi.ac.uk/interpro/entry/IPR003929
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR016040	http://www.ebi.ac.uk/interpro/entry/IPR016040
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	3778	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3778
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H01258	http://www.genome.jp/dbget-bin/www_bget?H01258
KEGG_Gene	hsa:3778	http://www.genome.jp/dbget-bin/www_bget?hsa:3778
KEGG_Orthology	KO:K04936	http://www.genome.jp/dbget-bin/www_bget?KO:K04936
KEGG_Pathway	ko04270	http://www.genome.jp/kegg-bin/show_pathway?ko04270
KEGG_Pathway	ko04970	http://www.genome.jp/kegg-bin/show_pathway?ko04970
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
MIM	600150	http://www.ncbi.nlm.nih.gov/omim/600150
MIM	609446	http://www.ncbi.nlm.nih.gov/omim/609446
MINT	MINT-4825316	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4825316
Orphanet	79137	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=79137
PDB	2K44	http://www.ebi.ac.uk/pdbe-srv/view/entry/2K44
PDB	3MT5	http://www.ebi.ac.uk/pdbe-srv/view/entry/3MT5
PDB	3NAF	http://www.ebi.ac.uk/pdbe-srv/view/entry/3NAF
PDBsum	2K44	http://www.ebi.ac.uk/pdbsum/2K44
PDBsum	3MT5	http://www.ebi.ac.uk/pdbsum/3MT5
PDBsum	3NAF	http://www.ebi.ac.uk/pdbsum/3NAF
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01449	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01449
PSORT	swissprot:KCMA1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCMA1_HUMAN
PSORT-B	swissprot:KCMA1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCMA1_HUMAN
PSORT2	swissprot:KCMA1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCMA1_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF03493	http://pfam.xfam.org/family/PF03493
PharmGKB	PA220	http://www.pharmgkb.org/do/serve?objId=PA220&objCls=Gene
Phobius	swissprot:KCMA1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCMA1_HUMAN
PhylomeDB	Q12791	http://phylomedb.org/?seqid=Q12791
ProteinModelPortal	Q12791	http://www.proteinmodelportal.org/query/uniprot/Q12791
PubMed	10097176	http://www.ncbi.nlm.nih.gov/pubmed/10097176
PubMed	10692449	http://www.ncbi.nlm.nih.gov/pubmed/10692449
PubMed	11604135	http://www.ncbi.nlm.nih.gov/pubmed/11604135
PubMed	11880485	http://www.ncbi.nlm.nih.gov/pubmed/11880485
PubMed	11880513	http://www.ncbi.nlm.nih.gov/pubmed/11880513
PubMed	12434576	http://www.ncbi.nlm.nih.gov/pubmed/12434576
PubMed	12566537	http://www.ncbi.nlm.nih.gov/pubmed/12566537
PubMed	14523450	http://www.ncbi.nlm.nih.gov/pubmed/14523450
PubMed	15164054	http://www.ncbi.nlm.nih.gov/pubmed/15164054
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15937479	http://www.ncbi.nlm.nih.gov/pubmed/15937479
PubMed	20430843	http://www.ncbi.nlm.nih.gov/pubmed/20430843
PubMed	20508092	http://www.ncbi.nlm.nih.gov/pubmed/20508092
PubMed	20613726	http://www.ncbi.nlm.nih.gov/pubmed/20613726
PubMed	20693285	http://www.ncbi.nlm.nih.gov/pubmed/20693285
PubMed	22399288	http://www.ncbi.nlm.nih.gov/pubmed/22399288
PubMed	22547800	http://www.ncbi.nlm.nih.gov/pubmed/22547800
PubMed	7573516	http://www.ncbi.nlm.nih.gov/pubmed/7573516
PubMed	7877450	http://www.ncbi.nlm.nih.gov/pubmed/7877450
PubMed	7987297	http://www.ncbi.nlm.nih.gov/pubmed/7987297
PubMed	7993625	http://www.ncbi.nlm.nih.gov/pubmed/7993625
PubMed	8821792	http://www.ncbi.nlm.nih.gov/pubmed/8821792
PubMed	8962157	http://www.ncbi.nlm.nih.gov/pubmed/8962157
PubMed	9391153	http://www.ncbi.nlm.nih.gov/pubmed/9391153
PubMed	9829973	http://www.ncbi.nlm.nih.gov/pubmed/9829973
Reactome	R-HSA-1296052	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296052
Reactome	R-HSA-418457	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418457
RefSeq	NP_001014797	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001014797
RefSeq	NP_001154824	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001154824
RefSeq	NP_001154825	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001154825
RefSeq	NP_001258447	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001258447
RefSeq	NP_001258451	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001258451
RefSeq	NP_002238	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002238
SMR	Q12791	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q12791
SUPFAM	SSF51735	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735
UCSC	uc001jxm	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001jxm&org=rat
UniGene	Hs.144795	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.144795
UniGene	Hs.658064	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.658064
UniProtKB	KCMA1_HUMAN	http://www.uniprot.org/uniprot/KCMA1_HUMAN
UniProtKB-AC	Q12791	http://www.uniprot.org/uniprot/Q12791
charge	swissprot:KCMA1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCMA1_HUMAN
epestfind	swissprot:KCMA1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCMA1_HUMAN
garnier	swissprot:KCMA1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCMA1_HUMAN
helixturnhelix	swissprot:KCMA1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCMA1_HUMAN
hmoment	swissprot:KCMA1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCMA1_HUMAN
iep	swissprot:KCMA1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCMA1_HUMAN
inforesidue	swissprot:KCMA1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCMA1_HUMAN
neXtProt	NX_Q12791	http://www.nextprot.org/db/entry/NX_Q12791
octanol	swissprot:KCMA1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCMA1_HUMAN
pepcoil	swissprot:KCMA1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCMA1_HUMAN
pepdigest	swissprot:KCMA1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCMA1_HUMAN
pepinfo	swissprot:KCMA1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCMA1_HUMAN
pepnet	swissprot:KCMA1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCMA1_HUMAN
pepstats	swissprot:KCMA1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCMA1_HUMAN
pepwheel	swissprot:KCMA1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCMA1_HUMAN
pepwindow	swissprot:KCMA1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCMA1_HUMAN
sigcleave	swissprot:KCMA1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCMA1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	MFSD5_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6N075-1; Sequence=Displayed; Name=2; IsoId=Q6N075-2; Sequence=VSP_046647; Note=No experimental confirmation available.; 
# AltName	MFSD5_HUMAN	Major facilitator superfamily domain-containing protein 5
# AltName	MFSD5_HUMAN	Molybdate transporter 2 homolog
# BIOPHYSICOCHEMICAL PROPERTIES	Kinetic parameters: KM=546 nM for molybdate (when expressed in yeast) {ECO	0000269|PubMed:21464289}; 
# BioGrid	124404	18
# CCDS	CCDS53796	-. [Q6N075-2]
# CCDS	CCDS8851	-. [Q6N075-1]
# Ensembl	ENST00000329548	ENSP00000332624; ENSG00000182544. [Q6N075-1]
# Ensembl	ENST00000534842	ENSP00000442688; ENSG00000182544. [Q6N075-2]
# ExpressionAtlas	Q6N075	baseline and differential
# FUNCTION	MFSD5_HUMAN	Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum. {ECO 0000269|PubMed 21464289}. 
# GO_component	GO:0005886	plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015098	molybdate ion transmembrane transporter activity; IEA:InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# Genevisible	Q6N075	HS
# HGNC	HGNC:28156	MFSD5
# INTERACTION	MFSD5_HUMAN	Q8N6L0 CCDC155; NbExp=3; IntAct=EBI-3920969, EBI-749265; Q96BA8 CREB3L1; NbExp=3; IntAct=EBI-3920969, EBI-6942903; 
# IntAct	Q6N075	5
# InterPro	IPR008509	MOT2/MFSD5
# InterPro	IPR020846	MFS_dom
# Organism	MFSD5_HUMAN	Homo sapiens (Human)
# Pfam	PF05631	MFS_5
# Proteomes	UP000005640	Chromosome 12
# RecName	MFSD5_HUMAN	Molybdate-anion transporter
# RefSeq	NP_001164261	NM_001170790.1. [Q6N075-2]
# RefSeq	NP_116278	NM_032889.4. [Q6N075-1]
# RefSeq	XP_005269254	XM_005269197.1. [Q6N075-2]
# RefSeq	XP_005269255	XM_005269198.4. [Q6N075-1]
# SEQUENCE CAUTION	Sequence=BAC05108.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=CAE45795.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the major facilitator superfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	MFSD5_HUMAN	Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF103473	SSF103473
# TISSUE SPECIFICITY	Expressed ubiquitously but at relatively higher levels in the olfactory bulb and the skeletal muscle. {ECO:0000269|PubMed	21044875}. 
# UCSC	uc001sch	human. [Q6N075-1]
# eggNOG	ENOG410XSP5	LUCA
# eggNOG	KOG4332	Eukaryota
BLAST	swissprot:MFSD5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MFSD5_HUMAN
BioCyc	ZFISH:G66-30923-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-30923-MONOMER
COXPRESdb	84975	http://coxpresdb.jp/data/gene/84975.shtml
CleanEx	HS_MFSD5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_MFSD5
DOI	10.1016/j.gene.2010.10.011	http://dx.doi.org/10.1016/j.gene.2010.10.011
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.1100700108	http://dx.doi.org/10.1073/pnas.1100700108
DOI	10.1093/dnares/12.2.117	http://dx.doi.org/10.1093/dnares/12.2.117
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AC021072	http://www.ebi.ac.uk/ena/data/view/AC021072
EMBL	AK074684	http://www.ebi.ac.uk/ena/data/view/AK074684
EMBL	AK097576	http://www.ebi.ac.uk/ena/data/view/AK097576
EMBL	AY358604	http://www.ebi.ac.uk/ena/data/view/AY358604
EMBL	BC007703	http://www.ebi.ac.uk/ena/data/view/BC007703
EMBL	BC067795	http://www.ebi.ac.uk/ena/data/view/BC067795
EMBL	BX640649	http://www.ebi.ac.uk/ena/data/view/BX640649
EMBL	CH471054	http://www.ebi.ac.uk/ena/data/view/CH471054
Ensembl	ENST00000329548	http://www.ensembl.org/id/ENST00000329548
Ensembl	ENST00000534842	http://www.ensembl.org/id/ENST00000534842
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015098	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015098
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GeneCards	MFSD5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=MFSD5
GeneID	84975	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84975
GeneTree	ENSGT00390000012629	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000012629
HGNC	HGNC:28156	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:28156
HOGENOM	HOG000239662	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000239662&db=HOGENOM6
HOVERGEN	HBG081970	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG081970&db=HOVERGEN
HPA	HPA039773	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA039773
InParanoid	Q6N075	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6N075
IntAct	Q6N075	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q6N075*
InterPro	IPR008509	http://www.ebi.ac.uk/interpro/entry/IPR008509
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	84975	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=84975
KEGG_Gene	hsa:84975	http://www.genome.jp/dbget-bin/www_bget?hsa:84975
MINT	MINT-4724121	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4724121
OMA	QGRVIPE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QGRVIPE
OrthoDB	EOG091G0CEM	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0CEM
PSORT	swissprot:MFSD5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MFSD5_HUMAN
PSORT-B	swissprot:MFSD5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MFSD5_HUMAN
PSORT2	swissprot:MFSD5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MFSD5_HUMAN
Pfam	PF05631	http://pfam.xfam.org/family/PF05631
PharmGKB	PA142671466	http://www.pharmgkb.org/do/serve?objId=PA142671466&objCls=Gene
Phobius	swissprot:MFSD5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MFSD5_HUMAN
PhylomeDB	Q6N075	http://phylomedb.org/?seqid=Q6N075
ProteinModelPortal	Q6N075	http://www.proteinmodelportal.org/query/uniprot/Q6N075
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16303743	http://www.ncbi.nlm.nih.gov/pubmed/16303743
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	21044875	http://www.ncbi.nlm.nih.gov/pubmed/21044875
PubMed	21464289	http://www.ncbi.nlm.nih.gov/pubmed/21464289
RefSeq	NP_001164261	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001164261
RefSeq	NP_116278	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_116278
RefSeq	XP_005269254	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005269254
RefSeq	XP_005269255	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005269255
STRING	9606.ENSP00000442688	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000442688&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
UCSC	uc001sch	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001sch&org=rat
UniGene	Hs.654660	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.654660
UniProtKB	MFSD5_HUMAN	http://www.uniprot.org/uniprot/MFSD5_HUMAN
UniProtKB-AC	Q6N075	http://www.uniprot.org/uniprot/Q6N075
charge	swissprot:MFSD5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MFSD5_HUMAN
eggNOG	ENOG410XSP5	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSP5
eggNOG	KOG4332	http://eggnogapi.embl.de/nog_data/html/tree/KOG4332
epestfind	swissprot:MFSD5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MFSD5_HUMAN
garnier	swissprot:MFSD5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MFSD5_HUMAN
helixturnhelix	swissprot:MFSD5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MFSD5_HUMAN
hmoment	swissprot:MFSD5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MFSD5_HUMAN
iep	swissprot:MFSD5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MFSD5_HUMAN
inforesidue	swissprot:MFSD5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MFSD5_HUMAN
neXtProt	NX_Q6N075	http://www.nextprot.org/db/entry/NX_Q6N075
octanol	swissprot:MFSD5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MFSD5_HUMAN
pepcoil	swissprot:MFSD5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MFSD5_HUMAN
pepdigest	swissprot:MFSD5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MFSD5_HUMAN
pepinfo	swissprot:MFSD5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MFSD5_HUMAN
pepnet	swissprot:MFSD5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MFSD5_HUMAN
pepstats	swissprot:MFSD5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MFSD5_HUMAN
pepwheel	swissprot:MFSD5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MFSD5_HUMAN
pepwindow	swissprot:MFSD5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MFSD5_HUMAN
sigcleave	swissprot:MFSD5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MFSD5_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ANXA6_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P08133-1; Sequence=Displayed; Name=2; IsoId=P08133-2; Sequence=VSP_045480; Note=No experimental confirmation available.; 
# AltName	ANXA6_HUMAN	67 kDa calelectrin
# AltName	ANXA6_HUMAN	Annexin VI
# AltName	ANXA6_HUMAN	Annexin-6
# AltName	ANXA6_HUMAN	Calphobindin-II
# AltName	ANXA6_HUMAN	Chromobindin-20
# AltName	ANXA6_HUMAN	Lipocortin VI
# AltName	ANXA6_HUMAN	Protein III
# AltName	ANXA6_HUMAN	p68
# AltName	ANXA6_HUMAN	p70
# BioGrid	106806	36
# CCDS	CCDS47315	-. [P08133-1]
# CCDS	CCDS54941	-. [P08133-2]
# ChiTaRS	ANXA6	human
# DOMAIN	ANXA6_HUMAN	A pair of annexin repeats may form one binding site for calcium and phospholipid. 
# Ensembl	ENST00000354546	ENSP00000346550; ENSG00000197043. [P08133-1]
# Ensembl	ENST00000523714	ENSP00000430517; ENSG00000197043. [P08133-2]
# ExpressionAtlas	P08133	baseline and differential
# FUNCTION	ANXA6_HUMAN	May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. 
# GO_component	GO:0005739	mitochondrion; IEA:GOC.
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005925	focal adhesion; IDA:UniProtKB.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0031902	late endosome membrane; IDA:UniProtKB.
# GO_component	GO:0042470	melanosome; IEA:UniProtKB-SubCell.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IEA:Ensembl.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005509	calcium ion binding; IEA:InterPro.
# GO_function	GO:0005525	GTP binding; IMP:UniProtKB.
# GO_function	GO:0005544	calcium-dependent phospholipid binding; IDA:UniProtKB.
# GO_function	GO:0008289	lipid binding; IMP:UniProtKB.
# GO_function	GO:0015276	ligand-gated ion channel activity; IMP:UniProtKB.
# GO_function	GO:0015485	cholesterol binding; IDA:UniProtKB.
# GO_function	GO:0042803	protein homodimerization activity; IMP:UniProtKB.
# GO_function	GO:0048306	calcium-dependent protein binding; IPI:AgBase.
# GO_process	GO:0006816	calcium ion transport; IEA:Ensembl.
# GO_process	GO:0006937	regulation of muscle contraction; IEA:Ensembl.
# GO_process	GO:0034220	ion transmembrane transport; IMP:UniProtKB.
# GO_process	GO:0051260	protein homooligomerization; IMP:UniProtKB.
# GO_process	GO:0051560	mitochondrial calcium ion homeostasis; IEA:Ensembl.
# GO_process	GO:0097190	apoptotic signaling pathway; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008289	lipid binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.10.220.10	-; 8.
# Genevisible	P08133	HS
# HGNC	HGNC:544	ANXA6
# INDUCTION	ANXA6_HUMAN	By Epstein-Barr virus (EBV). 
# IntAct	P08133	14
# InterPro	IPR001464	Annexin
# InterPro	IPR002393	AnnexinVI
# InterPro	IPR018252	Annexin_repeat_CS
# InterPro	IPR018502	Annexin_repeat
# MIM	114070	gene
# MISCELLANEOUS	ANXA6_HUMAN	Seems to bind one calcium ion with high affinity. 
# Organism	ANXA6_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10502:SF19	PTHR10502:SF19
# PDB	1M9I	X-ray; 2.65 A; A=2-673
# PIR	JU0032	AQHU68
# PRINTS	PR00196	ANNEXIN
# PRINTS	PR00202	ANNEXINVI
# PROSITE	PS00223	ANNEXIN; 8
# PTM	ANXA6_HUMAN	Phosphorylated in response to growth factor stimulation. 
# Pfam	PF00191	Annexin; 8
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-445355	Smooth Muscle Contraction
# RecName	ANXA6_HUMAN	Annexin A6
# RefSeq	NP_001146	NM_001155.4. [P08133-1]
# RefSeq	NP_001180473	NM_001193544.1. [P08133-2]
# SIMILARITY	Belongs to the annexin family. {ECO	0000305}. 
# SIMILARITY	Contains 8 annexin repeats. {ECO	0000305}.
# SMART	SM00335	ANX; 8
# SUBCELLULAR LOCATION	ANXA6_HUMAN	Cytoplasm {ECO 0000250}. Melanosome {ECO 0000269|PubMed 17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. 
# TCDB	1.A.31.1	the annexin (annexin) family
# UCSC	uc003ltl	human. [P08133-1]
# eggNOG	ENOG410XPUN	LUCA
# eggNOG	KOG0819	Eukaryota
BLAST	swissprot:ANXA6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ANXA6_HUMAN
COXPRESdb	309	http://coxpresdb.jp/data/gene/309.shtml
CleanEx	HS_ANXA6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ANXA6
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/jmbi.1996.0426	http://dx.doi.org/10.1006/jmbi.1996.0426
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr060363j	http://dx.doi.org/10.1021/pr060363j
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/BJ20040647	http://dx.doi.org/10.1042/BJ20040647
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1073/pnas.85.3.664	http://dx.doi.org/10.1073/pnas.85.3.664
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AC008641	http://www.ebi.ac.uk/ena/data/view/AC008641
EMBL	AK126836	http://www.ebi.ac.uk/ena/data/view/AK126836
EMBL	AK303078	http://www.ebi.ac.uk/ena/data/view/AK303078
EMBL	BC017046	http://www.ebi.ac.uk/ena/data/view/BC017046
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	D00510	http://www.ebi.ac.uk/ena/data/view/D00510
EMBL	J03578	http://www.ebi.ac.uk/ena/data/view/J03578
EMBL	Y00097	http://www.ebi.ac.uk/ena/data/view/Y00097
Ensembl	ENST00000354546	http://www.ensembl.org/id/ENST00000354546
Ensembl	ENST00000523714	http://www.ensembl.org/id/ENST00000523714
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005925	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005925
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0031902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031902
GO_component	GO:0042470	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042470
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0005525	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525
GO_function	GO:0005544	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005544
GO_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_function	GO:0015485	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015485
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_function	GO:0048306	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048306
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0006937	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006937
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:0051560	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051560
GO_process	GO:0097190	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097190
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.10.220.10	http://www.cathdb.info/version/latest/superfamily/1.10.220.10
GeneCards	ANXA6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ANXA6
GeneID	309	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=309
GeneTree	ENSGT00760000118972	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118972
HGNC	HGNC:544	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:544
HOGENOM	HOG000158803	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000158803&db=HOGENOM6
HOVERGEN	HBG061815	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG061815&db=HOVERGEN
HPA	CAB005077	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB005077
HPA	HPA002462	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA002462
HPA	HPA009650	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA009650
InParanoid	P08133	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08133
IntAct	P08133	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08133*
InterPro	IPR001464	http://www.ebi.ac.uk/interpro/entry/IPR001464
InterPro	IPR002393	http://www.ebi.ac.uk/interpro/entry/IPR002393
InterPro	IPR018252	http://www.ebi.ac.uk/interpro/entry/IPR018252
InterPro	IPR018502	http://www.ebi.ac.uk/interpro/entry/IPR018502
Jabion	309	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=309
KEGG_Gene	hsa:309	http://www.genome.jp/dbget-bin/www_bget?hsa:309
MIM	114070	http://www.ncbi.nlm.nih.gov/omim/114070
MINT	MINT-4999263	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4999263
OMA	QRQEICQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QRQEICQ
OrthoDB	EOG091G0H6H	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0H6H
PANTHER	PTHR10502:SF19	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10502:SF19
PDB	1M9I	http://www.ebi.ac.uk/pdbe-srv/view/entry/1M9I
PDBsum	1M9I	http://www.ebi.ac.uk/pdbsum/1M9I
PRINTS	PR00196	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00196
PRINTS	PR00202	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00202
PROSITE	PS00223	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00223
PSORT	swissprot:ANXA6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ANXA6_HUMAN
PSORT-B	swissprot:ANXA6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ANXA6_HUMAN
PSORT2	swissprot:ANXA6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ANXA6_HUMAN
Pfam	PF00191	http://pfam.xfam.org/family/PF00191
PharmGKB	PA24834	http://www.pharmgkb.org/do/serve?objId=PA24834&objCls=Gene
Phobius	swissprot:ANXA6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ANXA6_HUMAN
PhylomeDB	P08133	http://phylomedb.org/?seqid=P08133
ProteinModelPortal	P08133	http://www.proteinmodelportal.org/query/uniprot/P08133
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15242332	http://www.ncbi.nlm.nih.gov/pubmed/15242332
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17081065	http://www.ncbi.nlm.nih.gov/pubmed/17081065
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	2139657	http://www.ncbi.nlm.nih.gov/pubmed/2139657
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	2528541	http://www.ncbi.nlm.nih.gov/pubmed/2528541
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	2963335	http://www.ncbi.nlm.nih.gov/pubmed/2963335
PubMed	3258820	http://www.ncbi.nlm.nih.gov/pubmed/3258820
PubMed	8709144	http://www.ncbi.nlm.nih.gov/pubmed/8709144
Reactome	R-HSA-445355	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-445355
RefSeq	NP_001146	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001146
RefSeq	NP_001180473	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001180473
SMART	SM00335	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00335
SMR	P08133	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08133
STRING	9606.ENSP00000346550	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000346550&targetmode=cogs
TCDB	1.A.31.1	http://www.tcdb.org/search/result.php?tc=1.A.31.1
UCSC	uc003ltl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ltl&org=rat
UniGene	Hs.412117	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.412117
UniProtKB	ANXA6_HUMAN	http://www.uniprot.org/uniprot/ANXA6_HUMAN
UniProtKB-AC	P08133	http://www.uniprot.org/uniprot/P08133
charge	swissprot:ANXA6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ANXA6_HUMAN
eggNOG	ENOG410XPUN	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPUN
eggNOG	KOG0819	http://eggnogapi.embl.de/nog_data/html/tree/KOG0819
epestfind	swissprot:ANXA6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ANXA6_HUMAN
garnier	swissprot:ANXA6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ANXA6_HUMAN
helixturnhelix	swissprot:ANXA6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ANXA6_HUMAN
hmoment	swissprot:ANXA6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ANXA6_HUMAN
iep	swissprot:ANXA6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ANXA6_HUMAN
inforesidue	swissprot:ANXA6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ANXA6_HUMAN
neXtProt	NX_P08133	http://www.nextprot.org/db/entry/NX_P08133
octanol	swissprot:ANXA6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ANXA6_HUMAN
pepcoil	swissprot:ANXA6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ANXA6_HUMAN
pepdigest	swissprot:ANXA6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ANXA6_HUMAN
pepinfo	swissprot:ANXA6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ANXA6_HUMAN
pepnet	swissprot:ANXA6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ANXA6_HUMAN
pepstats	swissprot:ANXA6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ANXA6_HUMAN
pepwheel	swissprot:ANXA6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ANXA6_HUMAN
pepwindow	swissprot:ANXA6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ANXA6_HUMAN
sigcleave	swissprot:ANXA6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ANXA6_HUMAN
## Database	ID	URL or Descriptions
# AltName	NMDE2_HUMAN	Glutamate [NMDA] receptor subunit epsilon-2
# AltName	NMDE2_HUMAN	N-methyl D-aspartate receptor subtype 2B
# AltName	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 3
# BioGrid	109161	25
# DISEASE	NMDE2_HUMAN	Epileptic encephalopathy, early infantile, 27 (EIEE27) [MIM 616139]  A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	NMDE2_HUMAN	Mental retardation, autosomal dominant 6 (MRD6) [MIM 613970]  A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO 0000269|PubMed 20890276, ECO 0000269|PubMed 23033978, ECO 0000269|PubMed 23160955}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	NMDE2_HUMAN	Note=A chromosomal aberrations involving GRIN2B has been found in patients with mental retardation. Translocations t(9;12)(p23;p13.1) and t(10;12)(q21.1;p13.1) with a common breakpoint in 12p13.1. 
# DrugBank	DB00289	Atomoxetine
# DrugBank	DB00312	Pentobarbital
# DrugBank	DB00418	Secobarbital
# DrugBank	DB00454	Pethidine
# DrugBank	DB00502	Haloperidol
# DrugBank	DB00659	Acamprosate
# DrugBank	DB00949	Felbamate
# DrugBank	DB00996	Gabapentin
# DrugBank	DB01043	Memantine
# DrugBank	DB01174	Phenobarbital
# DrugBank	DB04896	Milnacipran
# DrugBank	DB06151	Acetylcysteine
# DrugBank	DB06738	Ketobemidone
# DrugBank	DB08954	Ifenprodil
# Ensembl	ENST00000609686	ENSP00000477455; ENSG00000273079
# ExpressionAtlas	Q13224	baseline and differential
# FUNCTION	NMDE2_HUMAN	NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity). {ECO 0000250}. 
# GO_component	GO:0005622	intracellular; IEA:GOC.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0009986	cell surface; ISS:BHF-UCL.
# GO_component	GO:0017146	NMDA selective glutamate receptor complex; IDA:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0043005	neuron projection; ISS:BHF-UCL.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0004972	NMDA glutamate receptor activity; TAS:ProtInc.
# GO_function	GO:0005088	Ras guanyl-nucleotide exchange factor activity; TAS:Reactome.
# GO_function	GO:0005234	extracellular-glutamate-gated ion channel activity; IEA:InterPro.
# GO_function	GO:0008270	zinc ion binding; ISS:UniProtKB.
# GO_function	GO:0016594	glycine binding; IDA:UniProtKB.
# GO_process	GO:0000165	MAPK cascade; TAS:Reactome.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007215	glutamate receptor signaling pathway; TAS:ProtInc.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:Reactome.
# GO_process	GO:0007611	learning or memory; TAS:ProtInc.
# GO_process	GO:0045471	response to ethanol; IDA:UniProtKB.
# GO_process	GO:0048013	ephrin receptor signaling pathway; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005622	intracellular
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# Genevisible	Q13224	HS
# HGNC	HGNC:4586	GRIN2B
# INTERACTION	NMDE2_HUMAN	Q9UQM7 CAMK2A; NbExp=3; IntAct=EBI-2256942, EBI-1383687; Q62936 Dlg3 (xeno); NbExp=4; IntAct=EBI-2256942, EBI-349596; P78352 DLG4; NbExp=2; IntAct=EBI-2256942, EBI-80389; P31016 Dlg4 (xeno); NbExp=2; IntAct=EBI-2256942, EBI-375655; P62139 PPP1CA (xeno); NbExp=2; IntAct=EBI-2256942, EBI-2008988; 
# IntAct	Q13224	13
# InterPro	IPR001320	Iontro_rcpt
# InterPro	IPR001508	Iono_rcpt_met
# InterPro	IPR001828	ANF_lig-bd_rcpt
# InterPro	IPR018884	NMDAR2_C
# InterPro	IPR019594	Glu/Gly-bd
# InterPro	IPR028082	Peripla_BP_I
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00773	[Congenital disorder; Mental retardation] Autosomal dominant mental retardation
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04713	Circadian entrainment
# KEGG_Pathway	ko04720	Long-term potentiation
# KEGG_Pathway	ko04724	Glutamatergic synapse
# KEGG_Pathway	ko04728	Dopaminergic synapse
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05014	Amyotrophic lateral sclerosis (ALS)
# KEGG_Pathway	ko05016	Huntington's disease
# KEGG_Pathway	ko05030	Cocaine addiction
# KEGG_Pathway	ko05031	Amphetamine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# KEGG_Pathway	ko05034	Alcoholism
# KEGG_Pathway	ko05322	Systemic lupus erythematosus
# MIM	138252	gene
# MIM	613970	phenotype
# MIM	616139	phenotype
# Organism	NMDE2_HUMAN	Homo sapiens (Human)
# Orphanet	178469	Autosomal dominant non-syndromic intellectual disability
# Orphanet	3451	West syndrome
# PDB	1S11	Model; -; A=403-543, B=660-801
# PDB	1S2S	Model; -; A=405-543, B=660-801
# PDB	2IPV	Model; -; X=404-768
# PDB	5EWJ	X-ray; 2.77 A; B/D=31-394
# PDB	5EWL	X-ray; 2.98 A; B/D=31-394
# PDB	5EWM	X-ray; 2.76 A; B/D=31-394
# PIR	I39066	I39066
# PIR	S52086	S52086
# PRINTS	PR00177	NMDARECEPTOR
# PTM	NMDE2_HUMAN	Phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity. {ECO 0000250}. 
# Pfam	PF00060	Lig_chan
# Pfam	PF01094	ANF_receptor
# Pfam	PF10565	NMDAR2_C
# Pfam	PF10613	Lig_chan-Glu_bd
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-3928662	EPHB-mediated forward signaling
# Reactome	R-HSA-438066	Unblocking of NMDA receptor, glutamate binding and activation
# Reactome	R-HSA-442729	CREB phosphorylation through the activation of CaMKII
# Reactome	R-HSA-442982	Ras activation uopn Ca2+ infux through NMDA receptor
# Reactome	R-HSA-5673001	RAF/MAP kinase cascade
# Reactome	R-HSA-6794361	Interactions of neurexins and neuroligins at synapses
# Reactome	R-HSA-8849932	SALM protein interactions at the synapses
# RecName	NMDE2_HUMAN	Glutamate receptor ionotropic, NMDA 2B
# RefSeq	NP_000825	NM_000834.3
# RefSeq	XP_011518930	XM_011520628.2
# RefSeq	XP_011518931	XM_011520629.2
# RefSeq	XP_016874708	XM_017019219.1
# SIMILARITY	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2B/GRIN2B subfamily. {ECO	0000305}.
# SMART	SM00079	PBPe
# SMART	SM00918	Lig_chan-Glu_bd
# SUBCELLULAR LOCATION	NMDE2_HUMAN	Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of PATJ and DLG4. Interacts with HIP1 and NETO1 (By similarity). Interacts with MAGI3. Interacts with DAPK1 (By similarity). {ECO	0000250}. 
# SUPFAM	SSF53822	SSF53822
# TISSUE SPECIFICITY	Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia. {ECO:0000269|PubMed	9547169}. 
# UCSC	uc001rbt	human
# eggNOG	ENOG410XNUR	LUCA
# eggNOG	KOG1053	Eukaryota
BLAST	swissprot:NMDE2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NMDE2_HUMAN
BioCyc	ZFISH:ENSG00000150086-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000150086-MONOMER
COXPRESdb	2904	http://coxpresdb.jp/data/gene/2904.shtml
CleanEx	HS_GRIN2B	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GRIN2B
DIP	DIP-41002N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-41002N
DOI	10.1002/ana.24073	http://dx.doi.org/10.1002/ana.24073
DOI	10.1006/geno.1994.1366	http://dx.doi.org/10.1006/geno.1994.1366
DOI	10.1016/0167-4781(94)00189-A	http://dx.doi.org/10.1016/0167-4781(94)00189-A
DOI	10.1016/S0304-3940(97)00853-7	http://dx.doi.org/10.1016/S0304-3940(97)00853-7
DOI	10.1038/ng.677	http://dx.doi.org/10.1038/ng.677
DOI	10.1056/NEJMoa1206524	http://dx.doi.org/10.1056/NEJMoa1206524
DOI	10.1074/jbc.M909741199	http://dx.doi.org/10.1074/jbc.M909741199
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1227764	http://dx.doi.org/10.1126/science.1227764
DrugBank	DB00289	http://www.drugbank.ca/drugs/DB00289
DrugBank	DB00312	http://www.drugbank.ca/drugs/DB00312
DrugBank	DB00418	http://www.drugbank.ca/drugs/DB00418
DrugBank	DB00454	http://www.drugbank.ca/drugs/DB00454
DrugBank	DB00502	http://www.drugbank.ca/drugs/DB00502
DrugBank	DB00659	http://www.drugbank.ca/drugs/DB00659
DrugBank	DB00949	http://www.drugbank.ca/drugs/DB00949
DrugBank	DB00996	http://www.drugbank.ca/drugs/DB00996
DrugBank	DB01043	http://www.drugbank.ca/drugs/DB01043
DrugBank	DB01174	http://www.drugbank.ca/drugs/DB01174
DrugBank	DB04896	http://www.drugbank.ca/drugs/DB04896
DrugBank	DB06151	http://www.drugbank.ca/drugs/DB06151
DrugBank	DB06738	http://www.drugbank.ca/drugs/DB06738
DrugBank	DB08954	http://www.drugbank.ca/drugs/DB08954
EMBL	BC113618	http://www.ebi.ac.uk/ena/data/view/BC113618
EMBL	BC113620	http://www.ebi.ac.uk/ena/data/view/BC113620
EMBL	U11287	http://www.ebi.ac.uk/ena/data/view/U11287
EMBL	U28758	http://www.ebi.ac.uk/ena/data/view/U28758
EMBL	U28861	http://www.ebi.ac.uk/ena/data/view/U28861
EMBL	U28862	http://www.ebi.ac.uk/ena/data/view/U28862
EMBL	U88963	http://www.ebi.ac.uk/ena/data/view/U88963
EMBL	U90278	http://www.ebi.ac.uk/ena/data/view/U90278
Ensembl	ENST00000609686	http://www.ensembl.org/id/ENST00000609686
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0017146	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017146
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0043005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043005
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0004972	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004972
GO_function	GO:0005088	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005088
GO_function	GO:0005234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005234
GO_function	GO:0008270	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270
GO_function	GO:0016594	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016594
GO_process	GO:0000165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000165
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007215
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007611	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007611
GO_process	GO:0045471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045471
GO_process	GO:0048013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048013
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	GRIN2B	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GRIN2B
GeneID	2904	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2904
GeneTree	ENSGT00760000119186	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119186
H-InvDB	HIX0036873	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0036873
HGNC	HGNC:4586	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4586
HOGENOM	HOG000113802	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000113802&db=HOGENOM6
HOVERGEN	HBG052635	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052635&db=HOVERGEN
HPA	HPA069762	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA069762
InParanoid	Q13224	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q13224
IntAct	Q13224	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q13224*
InterPro	IPR001320	http://www.ebi.ac.uk/interpro/entry/IPR001320
InterPro	IPR001508	http://www.ebi.ac.uk/interpro/entry/IPR001508
InterPro	IPR001828	http://www.ebi.ac.uk/interpro/entry/IPR001828
InterPro	IPR018884	http://www.ebi.ac.uk/interpro/entry/IPR018884
InterPro	IPR019594	http://www.ebi.ac.uk/interpro/entry/IPR019594
InterPro	IPR028082	http://www.ebi.ac.uk/interpro/entry/IPR028082
Jabion	2904	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2904
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00773	http://www.genome.jp/dbget-bin/www_bget?H00773
KEGG_Gene	hsa:2904	http://www.genome.jp/dbget-bin/www_bget?hsa:2904
KEGG_Orthology	KO:K05210	http://www.genome.jp/dbget-bin/www_bget?KO:K05210
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04713	http://www.genome.jp/kegg-bin/show_pathway?ko04713
KEGG_Pathway	ko04720	http://www.genome.jp/kegg-bin/show_pathway?ko04720
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
KEGG_Pathway	ko04728	http://www.genome.jp/kegg-bin/show_pathway?ko04728
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05014	http://www.genome.jp/kegg-bin/show_pathway?ko05014
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
KEGG_Pathway	ko05030	http://www.genome.jp/kegg-bin/show_pathway?ko05030
KEGG_Pathway	ko05031	http://www.genome.jp/kegg-bin/show_pathway?ko05031
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
KEGG_Pathway	ko05034	http://www.genome.jp/kegg-bin/show_pathway?ko05034
KEGG_Pathway	ko05322	http://www.genome.jp/kegg-bin/show_pathway?ko05322
MIM	138252	http://www.ncbi.nlm.nih.gov/omim/138252
MIM	613970	http://www.ncbi.nlm.nih.gov/omim/613970
MIM	616139	http://www.ncbi.nlm.nih.gov/omim/616139
MINT	MINT-127466	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-127466
OMA	CTNRSHL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CTNRSHL
Orphanet	178469	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=178469
Orphanet	3451	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=3451
OrthoDB	EOG091G09KH	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G09KH
PDB	1S11	http://www.ebi.ac.uk/pdbe-srv/view/entry/1S11
PDB	1S2S	http://www.ebi.ac.uk/pdbe-srv/view/entry/1S2S
PDB	2IPV	http://www.ebi.ac.uk/pdbe-srv/view/entry/2IPV
PDB	5EWJ	http://www.ebi.ac.uk/pdbe-srv/view/entry/5EWJ
PDB	5EWL	http://www.ebi.ac.uk/pdbe-srv/view/entry/5EWL
PDB	5EWM	http://www.ebi.ac.uk/pdbe-srv/view/entry/5EWM
PDBsum	1S11	http://www.ebi.ac.uk/pdbsum/1S11
PDBsum	1S2S	http://www.ebi.ac.uk/pdbsum/1S2S
PDBsum	2IPV	http://www.ebi.ac.uk/pdbsum/2IPV
PDBsum	5EWJ	http://www.ebi.ac.uk/pdbsum/5EWJ
PDBsum	5EWL	http://www.ebi.ac.uk/pdbsum/5EWL
PDBsum	5EWM	http://www.ebi.ac.uk/pdbsum/5EWM
PRINTS	PR00177	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00177
PSORT	swissprot:NMDE2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NMDE2_HUMAN
PSORT-B	swissprot:NMDE2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NMDE2_HUMAN
PSORT2	swissprot:NMDE2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NMDE2_HUMAN
Pfam	PF00060	http://pfam.xfam.org/family/PF00060
Pfam	PF01094	http://pfam.xfam.org/family/PF01094
Pfam	PF10565	http://pfam.xfam.org/family/PF10565
Pfam	PF10613	http://pfam.xfam.org/family/PF10613
PharmGKB	PA28980	http://www.pharmgkb.org/do/serve?objId=PA28980&objCls=Gene
Phobius	swissprot:NMDE2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NMDE2_HUMAN
PhylomeDB	Q13224	http://phylomedb.org/?seqid=Q13224
ProteinModelPortal	Q13224	http://www.proteinmodelportal.org/query/uniprot/Q13224
PubMed	10748157	http://www.ncbi.nlm.nih.gov/pubmed/10748157
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	20890276	http://www.ncbi.nlm.nih.gov/pubmed/20890276
PubMed	23033978	http://www.ncbi.nlm.nih.gov/pubmed/23033978
PubMed	23160955	http://www.ncbi.nlm.nih.gov/pubmed/23160955
PubMed	24272827	http://www.ncbi.nlm.nih.gov/pubmed/24272827
PubMed	7959773	http://www.ncbi.nlm.nih.gov/pubmed/7959773
PubMed	7999784	http://www.ncbi.nlm.nih.gov/pubmed/7999784
PubMed	8768735	http://www.ncbi.nlm.nih.gov/pubmed/8768735
PubMed	9547169	http://www.ncbi.nlm.nih.gov/pubmed/9547169
Reactome	R-HSA-3928662	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3928662
Reactome	R-HSA-438066	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-438066
Reactome	R-HSA-442729	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442729
Reactome	R-HSA-442982	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442982
Reactome	R-HSA-5673001	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5673001
Reactome	R-HSA-6794361	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6794361
Reactome	R-HSA-8849932	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8849932
RefSeq	NP_000825	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000825
RefSeq	XP_011518930	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011518930
RefSeq	XP_011518931	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011518931
RefSeq	XP_016874708	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016874708
SMART	SM00079	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00079
SMART	SM00918	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00918
SMR	Q13224	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q13224
STRING	9606.ENSP00000279593	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000279593&targetmode=cogs
SUPFAM	SSF53822	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822
UCSC	uc001rbt	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001rbt&org=rat
UniGene	Hs.504844	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.504844
UniGene	Hs.632856	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.632856
UniGene	Hs.654430	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.654430
UniProtKB	NMDE2_HUMAN	http://www.uniprot.org/uniprot/NMDE2_HUMAN
UniProtKB-AC	Q13224	http://www.uniprot.org/uniprot/Q13224
charge	swissprot:NMDE2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NMDE2_HUMAN
eggNOG	ENOG410XNUR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNUR
eggNOG	KOG1053	http://eggnogapi.embl.de/nog_data/html/tree/KOG1053
epestfind	swissprot:NMDE2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NMDE2_HUMAN
garnier	swissprot:NMDE2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NMDE2_HUMAN
helixturnhelix	swissprot:NMDE2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NMDE2_HUMAN
hmoment	swissprot:NMDE2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NMDE2_HUMAN
iep	swissprot:NMDE2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NMDE2_HUMAN
inforesidue	swissprot:NMDE2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NMDE2_HUMAN
neXtProt	NX_Q13224	http://www.nextprot.org/db/entry/NX_Q13224
octanol	swissprot:NMDE2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NMDE2_HUMAN
pepcoil	swissprot:NMDE2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NMDE2_HUMAN
pepdigest	swissprot:NMDE2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NMDE2_HUMAN
pepinfo	swissprot:NMDE2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NMDE2_HUMAN
pepnet	swissprot:NMDE2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NMDE2_HUMAN
pepstats	swissprot:NMDE2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NMDE2_HUMAN
pepwheel	swissprot:NMDE2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NMDE2_HUMAN
pepwindow	swissprot:NMDE2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NMDE2_HUMAN
sigcleave	swissprot:NMDE2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NMDE2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	PCFT_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96NT5-1; Sequence=Displayed; Name=2; IsoId=Q96NT5-2; Sequence=VSP_016053; Note=Inactive isoform which results in impaired folate absorption, giving rise to hereditary folate malabsorption (HFM).; 
# AltName	PCFT_HUMAN	G21
# AltName	PCFT_HUMAN	Heme carrier protein 1
# AltName	PCFT_HUMAN	PCFT/HCP1
# AltName	PCFT_HUMAN	Solute carrier family 46 member 1
# BIOPHYSICOCHEMICAL PROPERTIES	PCFT_HUMAN	Kinetic parameters  KM=1.3 uM for folic acid (at pH 5.5) {ECO 0000269|PubMed 17129779, ECO 0000269|PubMed 17475902}; KM=1.5 uM for folic acid (at pH 6.0) {ECO 0000269|PubMed 17129779, ECO 0000269|PubMed 17475902}; KM=2.7 uM for folic acid (at pH 6.5) {ECO 0000269|PubMed 17129779, ECO 0000269|PubMed 17475902}; KM=6.0 uM for folic acid (at pH 7.0) {ECO 0000269|PubMed 17129779, ECO 0000269|PubMed 17475902}; KM=56.2 uM for folic acid (at pH 7.5) {ECO 0000269|PubMed 17129779, ECO 0000269|PubMed 17475902}; pH dependence  Optimum pH is 4.0-5.5. Activity decreases above pH 5.5 and reaches negligible levels at neutral pH and above. {ECO 0000269|PubMed 17129779, ECO 0000269|PubMed 17475902}; 
# BioGrid	125236	2
# CCDS	CCDS74019	-. [Q96NT5-2]
# CCDS	CCDS74020	-. [Q96NT5-1]
# CDD	cd06174	MFS
# DISEASE	PCFT_HUMAN	Hereditary folate malabsorption (HFM) [MIM 229050]  Rare autosomal recessive disorder characterized by impaired intestinal folate absorption with folate deficiency resulting in anemia, hypoimmunoglobulinemia with recurrent infections, and recurrent or chronic diarrhea. In many patients, neurological abnormalities such as seizures or mental retardation become apparent during early childhood, attributed to impaired transport of folates into the central nervous system. When diagnosed early, the disorder can be treated by administration of folate. If untreated, it can be fatal and, if treatment is delayed, the neurological defects can become permanent. {ECO 0000269|PubMed 17129779, ECO 0000269|PubMed 17446347, ECO 0000269|PubMed 18559978, ECO 0000269|PubMed 20686069, ECO 0000269|PubMed 20805364, ECO 0000269|PubMed 21333572}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00158	Folic Acid
# DrugBank	DB00563	Methotrexate
# DrugBank	DB00795	Sulfasalazine
# Ensembl	ENST00000612814	ENSP00000480703; ENSG00000076351. [Q96NT5-1]
# Ensembl	ENST00000618626	ENSP00000483652; ENSG00000076351. [Q96NT5-2]
# ExpressionAtlas	Q96NT5	baseline and differential
# FUNCTION	PCFT_HUMAN	Has been shown to act both as an intestinal proton- coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme. {ECO 0000269|PubMed 17129779, ECO 0000269|PubMed 17156779, ECO 0000269|PubMed 17446347, ECO 0000269|PubMed 17475902}. 
# GO_component	GO:0005737	cytoplasm; ISS:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0009986	cell surface; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_component	GO:0031526	brush border membrane; IEA:Ensembl.
# GO_function	GO:0005542	folic acid binding; IEA:UniProtKB-KW.
# GO_function	GO:0008517	folic acid transporter activity; IDA:UniProtKB.
# GO_function	GO:0015078	hydrogen ion transmembrane transporter activity; IDA:BHF-UCL.
# GO_function	GO:0015232	heme transporter activity; TAS:Reactome.
# GO_function	GO:0015350	methotrexate transporter activity; IC:BHF-UCL.
# GO_process	GO:0006879	cellular iron ion homeostasis; TAS:Reactome.
# GO_process	GO:0015884	folic acid transport; IDA:UniProtKB.
# GO_process	GO:0046655	folic acid metabolic process; TAS:Reactome.
# GO_process	GO:0051958	methotrexate transport; IDA:BHF-UCL.
# GO_process	GO:0098829	intestinal folate absorption; IC:BHF-UCL.
# GO_process	GO:1902600	hydrogen ion transmembrane transport; IDA:BHF-UCL.
# GO_process	GO:1904447	folic acid import into cell; IDA:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0051186	cofactor metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q96NT5	HS
# HGNC	HGNC:30521	SLC46A1
# IntAct	Q96NT5	2
# InterPro	IPR005829	Sugar_transporter_CS
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H01252	[Hematologic disease] Hereditary folate malabsorption (HFM)
# MIM	229050	phenotype
# MIM	611672	gene
# Organism	PCFT_HUMAN	Homo sapiens (Human)
# Orphanet	90045	Hereditary folate malabsorption
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-196757	Metabolism of folate and pterines
# Reactome	R-HSA-917937	Iron uptake and transport
# RecName	PCFT_HUMAN	Proton-coupled folate transporter
# RefSeq	NP_001229295	NM_001242366.2. [Q96NT5-2]
# RefSeq	NP_542400	NM_080669.5. [Q96NT5-1]
# SIMILARITY	Belongs to the major facilitator superfamily. SLC46A family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	PCFT_HUMAN	Apical cell membrane; Multi-pass membrane protein. Cytoplasm {ECO 0000250}. Note=Localizes to the apical membrane of intestinal cells in iron-deficient cells, while it resides in the cytoplasm in iron-replete cells. {ECO 0000250}. 
# SUBUNIT	Monomer. {ECO:0000269|PubMed	23601781}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.50	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	PCFT_HUMAN	Expressed in kidney, liver, placenta, small intestine, spleen, retina and retinal pigment epithelium. Lower levels found in colon and testis. Very low levels in brain, lung, stomach, heart and muscle. In intestine, expressed in duodenum with lower levels in jejunum, ileum, cecum, rectum and segments of the colon. {ECO 0000269|PubMed 17129779, ECO 0000269|PubMed 17335806}. 
# UCSC	uc032ezi	human. [Q96NT5-1]
# WEB RESOURCE	PCFT_HUMAN	Name=Mendelian genes solute carrier family 46 (folate transporter), member 1 (SLC46A1); Note=Leiden Open Variation Database (LOVD); URL="http //www.lovd.nl/SLC46A1";
# eggNOG	ENOG410ZVCA	LUCA
# eggNOG	KOG2816	Eukaryota
BLAST	swissprot:PCFT_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:PCFT_HUMAN
BioCyc	ZFISH:ENSG00000076351-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000076351-MONOMER
COXPRESdb	113235	http://coxpresdb.jp/data/gene/113235.shtml
CleanEx	HS_SLC46A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC46A1
DOI	10.1016/j.cell.2005.06.025	http://dx.doi.org/10.1016/j.cell.2005.06.025
DOI	10.1016/j.cell.2006.09.041	http://dx.doi.org/10.1016/j.cell.2006.09.041
DOI	10.1016/j.febslet.2006.11.048	http://dx.doi.org/10.1016/j.febslet.2006.11.048
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1016/j.yexcr.2007.01.019	http://dx.doi.org/10.1016/j.yexcr.2007.01.019
DOI	10.1016/j.ymgme.2011.01.008	http://dx.doi.org/10.1016/j.ymgme.2011.01.008
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1074/jbc.M114.578252	http://dx.doi.org/10.1074/jbc.M114.578252
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/febs.12293	http://dx.doi.org/10.1111/febs.12293
DOI	10.1124/jpet.107.122606	http://dx.doi.org/10.1124/jpet.107.122606
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1152/ajpcell.00113.2010	http://dx.doi.org/10.1152/ajpcell.00113.2010
DOI	10.1182/blood-2007-02-077099	http://dx.doi.org/10.1182/blood-2007-02-077099
DOI	10.1182/blood-2008-04-150276	http://dx.doi.org/10.1182/blood-2008-04-150276
DOI	10.1182/blood-2010-06-291237	http://dx.doi.org/10.1182/blood-2010-06-291237
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DrugBank	DB00158	http://www.drugbank.ca/drugs/DB00158
DrugBank	DB00563	http://www.drugbank.ca/drugs/DB00563
DrugBank	DB00795	http://www.drugbank.ca/drugs/DB00795
EMBL	AK054669	http://www.ebi.ac.uk/ena/data/view/AK054669
EMBL	AK074161	http://www.ebi.ac.uk/ena/data/view/AK074161
EMBL	AL832613	http://www.ebi.ac.uk/ena/data/view/AL832613
EMBL	BC010691	http://www.ebi.ac.uk/ena/data/view/BC010691
EMBL	DQ496103	http://www.ebi.ac.uk/ena/data/view/DQ496103
Ensembl	ENST00000612814	http://www.ensembl.org/id/ENST00000612814
Ensembl	ENST00000618626	http://www.ensembl.org/id/ENST00000618626
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0031526	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031526
GO_function	GO:0005542	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005542
GO_function	GO:0008517	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008517
GO_function	GO:0015078	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015078
GO_function	GO:0015232	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015232
GO_function	GO:0015350	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015350
GO_process	GO:0006879	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006879
GO_process	GO:0015884	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015884
GO_process	GO:0046655	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046655
GO_process	GO:0051958	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051958
GO_process	GO:0098829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098829
GO_process	GO:1902600	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902600
GO_process	GO:1904447	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1904447
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0051186	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC46A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC46A1
GeneID	113235	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=113235
GeneTree	ENSGT00530000063076	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063076
H-InvDB	HIX0022189	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0022189
HGNC	HGNC:30521	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:30521
HOGENOM	HOG000054191	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054191&db=HOGENOM6
HOVERGEN	HBG055334	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG055334&db=HOVERGEN
HPA	CAB011614	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB011614
InParanoid	Q96NT5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96NT5
IntAct	Q96NT5	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96NT5*
InterPro	IPR005829	http://www.ebi.ac.uk/interpro/entry/IPR005829
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	113235	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=113235
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H01252	http://www.genome.jp/dbget-bin/www_bget?H01252
KEGG_Gene	hsa:113235	http://www.genome.jp/dbget-bin/www_bget?hsa:113235
KEGG_Orthology	KO:K14613	http://www.genome.jp/dbget-bin/www_bget?KO:K14613
MIM	229050	http://www.ncbi.nlm.nih.gov/omim/229050
MIM	611672	http://www.ncbi.nlm.nih.gov/omim/611672
OMA	FANTHAQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FANTHAQ
Orphanet	90045	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=90045
OrthoDB	EOG091G08MP	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08MP
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:PCFT_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:PCFT_HUMAN
PSORT-B	swissprot:PCFT_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:PCFT_HUMAN
PSORT2	swissprot:PCFT_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:PCFT_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA162403775	http://www.pharmgkb.org/do/serve?objId=PA162403775&objCls=Gene
Phobius	swissprot:PCFT_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:PCFT_HUMAN
PhylomeDB	Q96NT5	http://phylomedb.org/?seqid=Q96NT5
ProteinModelPortal	Q96NT5	http://www.proteinmodelportal.org/query/uniprot/Q96NT5
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16143108	http://www.ncbi.nlm.nih.gov/pubmed/16143108
PubMed	17129779	http://www.ncbi.nlm.nih.gov/pubmed/17129779
PubMed	17156779	http://www.ncbi.nlm.nih.gov/pubmed/17156779
PubMed	17335806	http://www.ncbi.nlm.nih.gov/pubmed/17335806
PubMed	17446347	http://www.ncbi.nlm.nih.gov/pubmed/17446347
PubMed	17475902	http://www.ncbi.nlm.nih.gov/pubmed/17475902
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18559978	http://www.ncbi.nlm.nih.gov/pubmed/18559978
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	20686069	http://www.ncbi.nlm.nih.gov/pubmed/20686069
PubMed	20805364	http://www.ncbi.nlm.nih.gov/pubmed/20805364
PubMed	21333572	http://www.ncbi.nlm.nih.gov/pubmed/21333572
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	23601781	http://www.ncbi.nlm.nih.gov/pubmed/23601781
PubMed	25053408	http://www.ncbi.nlm.nih.gov/pubmed/25053408
Reactome	R-HSA-196757	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-196757
Reactome	R-HSA-917937	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917937
RefSeq	NP_001229295	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001229295
RefSeq	NP_542400	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_542400
STRING	9606.ENSP00000395653	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000395653&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.50	http://www.tcdb.org/search/result.php?tc=2.A.1.50
UCSC	uc032ezi	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc032ezi&org=rat
UniGene	Hs.446689	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.446689
UniProtKB	PCFT_HUMAN	http://www.uniprot.org/uniprot/PCFT_HUMAN
UniProtKB-AC	Q96NT5	http://www.uniprot.org/uniprot/Q96NT5
charge	swissprot:PCFT_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:PCFT_HUMAN
eggNOG	ENOG410ZVCA	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZVCA
eggNOG	KOG2816	http://eggnogapi.embl.de/nog_data/html/tree/KOG2816
epestfind	swissprot:PCFT_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:PCFT_HUMAN
garnier	swissprot:PCFT_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:PCFT_HUMAN
helixturnhelix	swissprot:PCFT_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:PCFT_HUMAN
hmoment	swissprot:PCFT_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:PCFT_HUMAN
iep	swissprot:PCFT_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:PCFT_HUMAN
inforesidue	swissprot:PCFT_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:PCFT_HUMAN
neXtProt	NX_Q96NT5	http://www.nextprot.org/db/entry/NX_Q96NT5
octanol	swissprot:PCFT_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:PCFT_HUMAN
pepcoil	swissprot:PCFT_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:PCFT_HUMAN
pepdigest	swissprot:PCFT_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:PCFT_HUMAN
pepinfo	swissprot:PCFT_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:PCFT_HUMAN
pepnet	swissprot:PCFT_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:PCFT_HUMAN
pepstats	swissprot:PCFT_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:PCFT_HUMAN
pepwheel	swissprot:PCFT_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:PCFT_HUMAN
pepwindow	swissprot:PCFT_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:PCFT_HUMAN
sigcleave	swissprot:PCFT_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:PCFT_HUMAN
## Database	ID	URL or Descriptions
# AltName	GTR3_HUMAN	Glucose transporter type 3, brain
# BioGrid	112406	4
# CDD	cd06174	MFS
# ChiTaRS	SLC2A3	human
# DOMAIN	GTR3_HUMAN	Transport is mediated via a series of conformation changes, switching between a conformation where the substrate- binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm. {ECO 0000305|PubMed 26176916}. 
# Ensembl	ENST00000075120	ENSP00000075120; ENSG00000059804
# ExpressionAtlas	P11169	baseline and differential
# FUNCTION	GTR3_HUMAN	Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane (PubMed 9477959, PubMed 26176916). Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate (PubMed 9477959, PubMed 26176916). Does not mediate fructose transport (PubMed 9477959, PubMed 26176916). {ECO 0000269|PubMed 26176916, ECO 0000269|PubMed 9477959}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IMP:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005355	glucose transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0005536	glucose binding; IDA:UniProtKB.
# GO_function	GO:0033300	dehydroascorbic acid transporter activity; EXP:Reactome.
# GO_function	GO:0055056	D-glucose transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0005975	carbohydrate metabolic process; NAS:ProtInc.
# GO_process	GO:0015758	glucose transport; TAS:Reactome.
# GO_process	GO:0019852	L-ascorbic acid metabolic process; TAS:Reactome.
# GO_process	GO:1904659	glucose transmembrane transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0005975	carbohydrate metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P11169	HS
# HGNC	HGNC:11007	SLC2A3
# IntAct	P11169	6
# InterPro	IPR002945	Glc_transpt_3
# InterPro	IPR003663	Sugar/inositol_transpt
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR005829	Sugar_transporter_CS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	138170	gene
# Organism	GTR3_HUMAN	Homo sapiens (Human)
# Orphanet	399	Huntington disease
# PDB	4ZW9	X-ray; 1.50 A; A=1-496
# PDB	4ZWB	X-ray; 2.40 A; A=1-496
# PDB	4ZWC	X-ray; 2.60 A; A/B=1-496
# PDB	5C65	X-ray; 2.65 A; A/B=1-474
# PIR	A31986	A31986
# PIR	T14798	T14798
# PRINTS	PR00171	SUGRTRNSPORT
# PRINTS	PR01192	GLUCTRSPORT3
# PROSITE	PS00216	SUGAR_TRANSPORT_1
# PROSITE	PS00217	SUGAR_TRANSPORT_2
# PROSITE	PS50850	MFS
# Pfam	PF00083	Sugar_tr
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-196836	Vitamin C (ascorbate) metabolism
# Reactome	R-HSA-428790	Facilitative Na+-independent glucose transporters
# Reactome	R-HSA-6798695	Neutrophil degranulation
# Reactome	R-HSA-70153	Glucose transport
# RecName	GTR3_HUMAN	Solute carrier family 2, facilitated glucose transporter member 3
# RefSeq	NP_008862	NM_006931.2
# SIMILARITY	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	GTR3_HUMAN	Cell membrane {ECO 0000269|PubMed 9477959, ECO 0000305|PubMed 26176916}; Multi-pass membrane protein {ECO 0000269|PubMed 26176916}. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.1.1.91	the major facilitator superfamily (mfs)
# TIGRFAMs	TIGR00879	SP
# TISSUE SPECIFICITY	Highly expressed in brain. Expressed in many tissues. {ECO:0000269|PubMed	3170580}. 
# UCSC	uc001qtr	human
# eggNOG	COG0477	LUCA
# eggNOG	KOG0569	Eukaryota
BLAST	swissprot:GTR3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GTR3_HUMAN
BioCyc	ZFISH:ENSG00000059804-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000059804-MONOMER
COXPRESdb	6515	http://coxpresdb.jp/data/gene/6515.shtml
CleanEx	HS_SLC2A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC2A3
DOI	10.1021/bi972322u	http://dx.doi.org/10.1021/bi972322u
DOI	10.1038/nature14655	http://dx.doi.org/10.1038/nature14655
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF274889	http://www.ebi.ac.uk/ena/data/view/AF274889
EMBL	AF274890	http://www.ebi.ac.uk/ena/data/view/AF274890
EMBL	AF274891	http://www.ebi.ac.uk/ena/data/view/AF274891
EMBL	AF274892	http://www.ebi.ac.uk/ena/data/view/AF274892
EMBL	AK312386	http://www.ebi.ac.uk/ena/data/view/AK312386
EMBL	AY034634	http://www.ebi.ac.uk/ena/data/view/AY034634
EMBL	BC039196	http://www.ebi.ac.uk/ena/data/view/BC039196
EMBL	CH471116	http://www.ebi.ac.uk/ena/data/view/CH471116
EMBL	CH471116	http://www.ebi.ac.uk/ena/data/view/CH471116
EMBL	CR457413	http://www.ebi.ac.uk/ena/data/view/CR457413
EMBL	M20681	http://www.ebi.ac.uk/ena/data/view/M20681
Ensembl	ENST00000075120	http://www.ensembl.org/id/ENST00000075120
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005355	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005355
GO_function	GO:0005536	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005536
GO_function	GO:0033300	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033300
GO_function	GO:0055056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055056
GO_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GO_process	GO:0015758	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015758
GO_process	GO:0019852	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019852
GO_process	GO:1904659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1904659
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC2A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC2A3
GeneID	6515	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6515
GeneTree	ENSGT00760000119022	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119022
HGNC	HGNC:11007	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11007
HOGENOM	HOG000202871	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202871&db=HOGENOM6
HOVERGEN	HBG014816	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG014816&db=HOVERGEN
HPA	CAB002763	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB002763
HPA	HPA006539	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA006539
InParanoid	P11169	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P11169
IntAct	P11169	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P11169*
InterPro	IPR002945	http://www.ebi.ac.uk/interpro/entry/IPR002945
InterPro	IPR003663	http://www.ebi.ac.uk/interpro/entry/IPR003663
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR005829	http://www.ebi.ac.uk/interpro/entry/IPR005829
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	6515	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6515
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6515	http://www.genome.jp/dbget-bin/www_bget?hsa:6515
KEGG_Orthology	KO:K08142	http://www.genome.jp/dbget-bin/www_bget?KO:K08142
MIM	138170	http://www.ncbi.nlm.nih.gov/omim/138170
MINT	MINT-4999361	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4999361
OMA	XLFLVER	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=XLFLVER
Orphanet	399	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=399
OrthoDB	EOG091G0A9K	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0A9K
PDB	4ZW9	http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZW9
PDB	4ZWB	http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZWB
PDB	4ZWC	http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZWC
PDB	5C65	http://www.ebi.ac.uk/pdbe-srv/view/entry/5C65
PDBsum	4ZW9	http://www.ebi.ac.uk/pdbsum/4ZW9
PDBsum	4ZWB	http://www.ebi.ac.uk/pdbsum/4ZWB
PDBsum	4ZWC	http://www.ebi.ac.uk/pdbsum/4ZWC
PDBsum	5C65	http://www.ebi.ac.uk/pdbsum/5C65
PRINTS	PR00171	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00171
PRINTS	PR01192	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01192
PROSITE	PS00216	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00216
PROSITE	PS00217	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00217
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:GTR3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GTR3_HUMAN
PSORT-B	swissprot:GTR3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GTR3_HUMAN
PSORT2	swissprot:GTR3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GTR3_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
PharmGKB	PA35877	http://www.pharmgkb.org/do/serve?objId=PA35877&objCls=Gene
Phobius	swissprot:GTR3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GTR3_HUMAN
PhylomeDB	P11169	http://phylomedb.org/?seqid=P11169
ProteinModelPortal	P11169	http://www.proteinmodelportal.org/query/uniprot/P11169
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	26176916	http://www.ncbi.nlm.nih.gov/pubmed/26176916
PubMed	3170580	http://www.ncbi.nlm.nih.gov/pubmed/3170580
PubMed	9477959	http://www.ncbi.nlm.nih.gov/pubmed/9477959
Reactome	R-HSA-196836	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-196836
Reactome	R-HSA-428790	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428790
Reactome	R-HSA-6798695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6798695
Reactome	R-HSA-70153	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-70153
RefSeq	NP_008862	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_008862
SMR	P11169	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P11169
STRING	9606.ENSP00000075120	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000075120&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.1.91	http://www.tcdb.org/search/result.php?tc=2.A.1.1.91
TIGRFAMs	TIGR00879	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00879
UCSC	uc001qtr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001qtr&org=rat
UniGene	Hs.419240	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.419240
UniProtKB	GTR3_HUMAN	http://www.uniprot.org/uniprot/GTR3_HUMAN
UniProtKB-AC	P11169	http://www.uniprot.org/uniprot/P11169
charge	swissprot:GTR3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GTR3_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG0569	http://eggnogapi.embl.de/nog_data/html/tree/KOG0569
epestfind	swissprot:GTR3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GTR3_HUMAN
garnier	swissprot:GTR3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GTR3_HUMAN
helixturnhelix	swissprot:GTR3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GTR3_HUMAN
hmoment	swissprot:GTR3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GTR3_HUMAN
iep	swissprot:GTR3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GTR3_HUMAN
inforesidue	swissprot:GTR3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GTR3_HUMAN
neXtProt	NX_P11169	http://www.nextprot.org/db/entry/NX_P11169
octanol	swissprot:GTR3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GTR3_HUMAN
pepcoil	swissprot:GTR3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GTR3_HUMAN
pepdigest	swissprot:GTR3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GTR3_HUMAN
pepinfo	swissprot:GTR3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GTR3_HUMAN
pepnet	swissprot:GTR3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GTR3_HUMAN
pepstats	swissprot:GTR3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GTR3_HUMAN
pepwheel	swissprot:GTR3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GTR3_HUMAN
pepwindow	swissprot:GTR3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GTR3_HUMAN
sigcleave	swissprot:GTR3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GTR3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GRIK3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13003-1; Sequence=Displayed; Name=2; IsoId=Q13003-2; Sequence=VSP_056588; 
# AltName	GRIK3_HUMAN	Excitatory amino acid receptor 5
# AltName	GRIK3_HUMAN	Glutamate receptor 7
# BioGrid	109156	2
# CCDS	CCDS416	-. [Q13003-1]
# ChiTaRS	GRIK3	human
# Ensembl	ENST00000373091	ENSP00000362183; ENSG00000163873. [Q13003-1]
# Ensembl	ENST00000373093	ENSP00000362185; ENSG00000163873. [Q13003-2]
# FUNCTION	GRIK3_HUMAN	Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030424	axon; ISS:UniProtKB.
# GO_component	GO:0030425	dendrite; ISS:UniProtKB.
# GO_component	GO:0032839	dendrite cytoplasm; ISS:UniProtKB.
# GO_component	GO:0043195	terminal bouton; ISS:UniProtKB.
# GO_component	GO:0043204	perikaryon; ISS:UniProtKB.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0001640	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity; IDA:UniProtKB.
# GO_function	GO:0001664	G-protein coupled receptor binding; TAS:Reactome.
# GO_function	GO:0004970	ionotropic glutamate receptor activity; ISS:UniProtKB.
# GO_function	GO:0005234	extracellular-glutamate-gated ion channel activity; IEA:InterPro.
# GO_function	GO:0008066	glutamate receptor activity; TAS:UniProtKB.
# GO_function	GO:0015276	ligand-gated ion channel activity; TAS:Reactome.
# GO_function	GO:0015277	kainate selective glutamate receptor activity; IDA:UniProtKB.
# GO_process	GO:0007215	glutamate receptor signaling pathway; IDA:UniProtKB.
# GO_process	GO:0007216	G-protein coupled glutamate receptor signaling pathway; IDA:UniProtKB.
# GO_process	GO:0042391	regulation of membrane potential; ISS:UniProtKB.
# GO_process	GO:0051967	negative regulation of synaptic transmission, glutamatergic; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q13003	HS
# HGNC	HGNC:4581	GRIK3
# InterPro	IPR001320	Iontro_rcpt
# InterPro	IPR001508	Iono_rcpt_met
# InterPro	IPR001828	ANF_lig-bd_rcpt
# InterPro	IPR019594	Glu/Gly-bd
# InterPro	IPR028082	Peripla_BP_I
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04724	Glutamatergic synapse
# MIM	138243	gene
# Organism	GRIK3_HUMAN	Homo sapiens (Human)
# PIR	I59604	I59604
# PRINTS	PR00177	NMDARECEPTOR
# Pfam	PF00060	Lig_chan
# Pfam	PF01094	ANF_receptor
# Pfam	PF10613	Lig_chan-Glu_bd
# Proteomes	UP000005640	Chromosome 1
# RNA EDITING	Modified_positions=352 {ECO:0000269|PubMed	7719709}; Note=Partially edited.; 
# Reactome	R-HSA-451308	Activation of Ca-permeable Kainate Receptor
# Reactome	R-HSA-500657	Presynaptic function of Kainate receptors
# RecName	GRIK3_HUMAN	Glutamate receptor ionotropic, kainate 3
# RefSeq	NP_000822	NM_000831.3. [Q13003-1]
# SIMILARITY	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK3 subfamily. {ECO	0000305}.
# SMART	SM00079	PBPe
# SMART	SM00918	Lig_chan-Glu_bd
# SUBCELLULAR LOCATION	GRIK3_HUMAN	Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Homotetramer, and heterotetramer with either GRIK4 or GRIK5. Interacts with PRKCABP (By similarity). Interacts with NETO2 (By similarity). {ECO	0000250}. 
# SUPFAM	SSF53822	SSF53822
# UCSC	uc001caz	human. [Q13003-1]
# eggNOG	ENOG410XPSH	LUCA
# eggNOG	KOG1054	Eukaryota
BLAST	swissprot:GRIK3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GRIK3_HUMAN
BioCyc	ZFISH:ENSG00000163873-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000163873-MONOMER
COXPRESdb	2899	http://coxpresdb.jp/data/gene/2899.shtml
CleanEx	HS_GRIK3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GRIK3
DOI	10.1007/BF01233385	http://dx.doi.org/10.1007/BF01233385
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
EMBL	AC117945	http://www.ebi.ac.uk/ena/data/view/AC117945
EMBL	AJ249210	http://www.ebi.ac.uk/ena/data/view/AJ249210
EMBL	AL355386	http://www.ebi.ac.uk/ena/data/view/AL355386
EMBL	AL591883	http://www.ebi.ac.uk/ena/data/view/AL591883
EMBL	CH471059	http://www.ebi.ac.uk/ena/data/view/CH471059
EMBL	CH471059	http://www.ebi.ac.uk/ena/data/view/CH471059
EMBL	S69349	http://www.ebi.ac.uk/ena/data/view/S69349
EMBL	U16127	http://www.ebi.ac.uk/ena/data/view/U16127
EMBL	U16128	http://www.ebi.ac.uk/ena/data/view/U16128
Ensembl	ENST00000373091	http://www.ensembl.org/id/ENST00000373091
Ensembl	ENST00000373093	http://www.ensembl.org/id/ENST00000373093
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030424	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030424
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0032839	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032839
GO_component	GO:0043195	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043195
GO_component	GO:0043204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043204
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0001640	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001640
GO_function	GO:0001664	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001664
GO_function	GO:0004970	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004970
GO_function	GO:0005234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005234
GO_function	GO:0008066	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008066
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_function	GO:0015277	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015277
GO_process	GO:0007215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007215
GO_process	GO:0007216	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007216
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0051967	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051967
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	GRIK3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GRIK3
GeneID	2899	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2899
GeneTree	ENSGT00760000118920	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118920
H-InvDB	HIX0028621	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0028621
HGNC	HGNC:4581	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4581
HOGENOM	HOG000234371	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234371&db=HOGENOM6
HOVERGEN	HBG051839	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051839&db=HOVERGEN
HPA	HPA014709	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014709
InParanoid	Q13003	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q13003
InterPro	IPR001320	http://www.ebi.ac.uk/interpro/entry/IPR001320
InterPro	IPR001508	http://www.ebi.ac.uk/interpro/entry/IPR001508
InterPro	IPR001828	http://www.ebi.ac.uk/interpro/entry/IPR001828
InterPro	IPR019594	http://www.ebi.ac.uk/interpro/entry/IPR019594
InterPro	IPR028082	http://www.ebi.ac.uk/interpro/entry/IPR028082
Jabion	2899	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2899
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:2899	http://www.genome.jp/dbget-bin/www_bget?hsa:2899
KEGG_Orthology	KO:K05203	http://www.genome.jp/dbget-bin/www_bget?KO:K05203
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
MIM	138243	http://www.ncbi.nlm.nih.gov/omim/138243
OMA	HILKQAM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HILKQAM
OrthoDB	EOG091G02LN	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02LN
PRINTS	PR00177	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00177
PSORT	swissprot:GRIK3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GRIK3_HUMAN
PSORT-B	swissprot:GRIK3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GRIK3_HUMAN
PSORT2	swissprot:GRIK3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GRIK3_HUMAN
Pfam	PF00060	http://pfam.xfam.org/family/PF00060
Pfam	PF01094	http://pfam.xfam.org/family/PF01094
Pfam	PF10613	http://pfam.xfam.org/family/PF10613
PharmGKB	PA28975	http://www.pharmgkb.org/do/serve?objId=PA28975&objCls=Gene
Phobius	swissprot:GRIK3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GRIK3_HUMAN
PhylomeDB	Q13003	http://phylomedb.org/?seqid=Q13003
ProteinModelPortal	Q13003	http://www.proteinmodelportal.org/query/uniprot/Q13003
PubMed	11124978	http://www.ncbi.nlm.nih.gov/pubmed/11124978
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	7719709	http://www.ncbi.nlm.nih.gov/pubmed/7719709
PubMed	8128318	http://www.ncbi.nlm.nih.gov/pubmed/8128318
Reactome	R-HSA-451308	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-451308
Reactome	R-HSA-500657	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-500657
RefSeq	NP_000822	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000822
SMART	SM00079	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00079
SMART	SM00918	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00918
SMR	Q13003	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q13003
STRING	9606.ENSP00000362183	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000362183&targetmode=cogs
SUPFAM	SSF53822	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822
UCSC	uc001caz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001caz&org=rat
UniGene	Hs.128848	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.128848
UniProtKB	GRIK3_HUMAN	http://www.uniprot.org/uniprot/GRIK3_HUMAN
UniProtKB-AC	Q13003	http://www.uniprot.org/uniprot/Q13003
charge	swissprot:GRIK3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GRIK3_HUMAN
eggNOG	ENOG410XPSH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPSH
eggNOG	KOG1054	http://eggnogapi.embl.de/nog_data/html/tree/KOG1054
epestfind	swissprot:GRIK3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GRIK3_HUMAN
garnier	swissprot:GRIK3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GRIK3_HUMAN
helixturnhelix	swissprot:GRIK3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GRIK3_HUMAN
hmoment	swissprot:GRIK3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GRIK3_HUMAN
iep	swissprot:GRIK3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GRIK3_HUMAN
inforesidue	swissprot:GRIK3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GRIK3_HUMAN
neXtProt	NX_Q13003	http://www.nextprot.org/db/entry/NX_Q13003
octanol	swissprot:GRIK3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GRIK3_HUMAN
pepcoil	swissprot:GRIK3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GRIK3_HUMAN
pepdigest	swissprot:GRIK3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GRIK3_HUMAN
pepinfo	swissprot:GRIK3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GRIK3_HUMAN
pepnet	swissprot:GRIK3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GRIK3_HUMAN
pepstats	swissprot:GRIK3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GRIK3_HUMAN
pepwheel	swissprot:GRIK3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GRIK3_HUMAN
pepwindow	swissprot:GRIK3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GRIK3_HUMAN
sigcleave	swissprot:GRIK3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GRIK3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	VATH_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UI12-1; Sequence=Displayed; Name=2; IsoId=Q9UI12-2; Sequence=VSP_012274; 
# AltName	VATH_HUMAN	Nef-binding protein 1
# AltName	VATH_HUMAN	Protein VMA13 homolog
# AltName	VATH_HUMAN	V-ATPase 50/57 kDa subunits
# AltName	VATH_HUMAN	Vacuolar proton pump subunit H
# AltName	VATH_HUMAN	Vacuolar proton pump subunit SFD
# BioGrid	119635	46
# CCDS	CCDS6153	-. [Q9UI12-1]
# CCDS	CCDS6154	-. [Q9UI12-2]
# ChiTaRS	ATP6V1H	human
# Ensembl	ENST00000355221	ENSP00000347359; ENSG00000047249. [Q9UI12-2]
# Ensembl	ENST00000359530	ENSP00000352522; ENSG00000047249. [Q9UI12-1]
# Ensembl	ENST00000396774	ENSP00000379995; ENSG00000047249. [Q9UI12-1]
# ExpressionAtlas	Q9UI12	baseline and differential
# FUNCTION	VATH_HUMAN	Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes. {ECO 0000250}. 
# GO_component	GO:0000221	vacuolar proton-transporting V-type ATPase, V1 domain; NAS:UniProtKB.
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0030234	enzyme regulator activity; NAS:UniProtKB.
# GO_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
# GO_process	GO:0006897	endocytosis; IDA:UniProtKB.
# GO_process	GO:0007035	vacuolar acidification; NAS:UniProtKB.
# GO_process	GO:0008286	insulin receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0015991	ATP hydrolysis coupled proton transport; NAS:UniProtKB.
# GO_process	GO:0016032	viral process; IEA:UniProtKB-KW.
# GO_process	GO:0016241	regulation of macroautophagy; NAS:ParkinsonsUK-UCL.
# GO_process	GO:0033572	transferrin transport; TAS:Reactome.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0050690	regulation of defense response to virus by virus; TAS:Reactome.
# GO_process	GO:0090383	phagosome acidification; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0030234	enzyme regulator activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.25.10.10	-; 1.
# Gene3D	1.25.40.150	-; 1.
# Genevisible	Q9UI12	HS
# HGNC	HGNC:18303	ATP6V1H
# IntAct	Q9UI12	13
# InterPro	IPR004908	ATPase_V1-cplx_hsu
# InterPro	IPR011987	ATPase_V1-cplx_hsu_C
# InterPro	IPR011989	ARM-like
# InterPro	IPR016024	ARM-type_fold
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04142	Lysosome
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko05110	Vibrio cholerae infection
# KEGG_Pathway	ko05120	Epithelial cell signaling in Helicobacter pylori infection
# KEGG_Pathway	ko05152	Tuberculosis
# KEGG_Pathway	ko05323	Rheumatoid arthritis
# MIM	608861	gene
# Organism	VATH_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10698	PTHR10698
# PIRSF	PIRSF032184	ATPase_V1_H
# Pfam	PF11698	V-ATPase_H_C
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-1222556	ROS, RNS production in response to bacteria
# Reactome	R-HSA-167590	Nef Mediated CD4 Down-regulation
# Reactome	R-HSA-182218	Nef Mediated CD8 Down-regulation
# Reactome	R-HSA-77387	Insulin receptor recycling
# Reactome	R-HSA-917977	Transferrin endocytosis and recycling
# Reactome	R-HSA-983712	Ion channel transport
# RecName	VATH_HUMAN	V-type proton ATPase subunit H
# RefSeq	NP_057025	NM_015941.3. [Q9UI12-1]
# RefSeq	NP_998784	NM_213619.2. [Q9UI12-2]
# RefSeq	NP_998785	NM_213620.2. [Q9UI12-1]
# RefSeq	XP_006716518	XM_006716455.2. [Q9UI12-2]
# SIMILARITY	Belongs to the V-ATPase H subunit family. {ECO	0000305}.
# SUBUNIT	VATH_HUMAN	V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components  a, c, c', c'' and d). Interacts with HIV-1 Nef protein (PubMed 12032142, PubMed 9620685). Interacts with AP2M1 (PubMed 12032142). Interacts with TM9SF4 in colon cancer cells (PubMed 25659576). {ECO 0000269|PubMed 12032142, ECO 0000269|PubMed 25659576, ECO 0000269|PubMed 9620685}. 
# SUPFAM	SSF48371	SSF48371
# TCDB	3.A.2.2	the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily
# TISSUE SPECIFICITY	Widely expressed. {ECO:0000269|PubMed	9620685}. 
# UCSC	uc003xrl	human. [Q9UI12-1]
# eggNOG	COG5231	LUCA
# eggNOG	KOG2759	Eukaryota
BLAST	swissprot:VATH_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VATH_HUMAN
BioCyc	MetaCyc:HS00586-MONOMER	http://biocyc.org/getid?id=MetaCyc:HS00586-MONOMER
BioCyc	ZFISH:HS00586-MONOMER	http://biocyc.org/getid?id=ZFISH:HS00586-MONOMER
COXPRESdb	51606	http://coxpresdb.jp/data/gene/51606.shtml
CleanEx	HS_ATP6V1H	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP6V1H
DOI	10.1016/S1074-7613(00)80569-5	http://dx.doi.org/10.1016/S1074-7613(00)80569-5
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/onc.2014.437	http://dx.doi.org/10.1038/onc.2014.437
DOI	10.1073/pnas.160270997	http://dx.doi.org/10.1073/pnas.160270997
DOI	10.1074/jbc.M200522200	http://dx.doi.org/10.1074/jbc.M200522200
DOI	10.1101/gr.10.5.703	http://dx.doi.org/10.1101/gr.10.5.703
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF112204	http://www.ebi.ac.uk/ena/data/view/AF112204
EMBL	AF113222	http://www.ebi.ac.uk/ena/data/view/AF113222
EMBL	AF132945	http://www.ebi.ac.uk/ena/data/view/AF132945
EMBL	AF298777	http://www.ebi.ac.uk/ena/data/view/AF298777
EMBL	AK022345	http://www.ebi.ac.uk/ena/data/view/AK022345
EMBL	BC025275	http://www.ebi.ac.uk/ena/data/view/BC025275
EMBL	CH471068	http://www.ebi.ac.uk/ena/data/view/CH471068
Ensembl	ENST00000355221	http://www.ensembl.org/id/ENST00000355221
Ensembl	ENST00000359530	http://www.ensembl.org/id/ENST00000359530
Ensembl	ENST00000396774	http://www.ensembl.org/id/ENST00000396774
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000221	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000221
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0030234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234
GO_function	GO:0046961	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046961
GO_process	GO:0006897	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006897
GO_process	GO:0007035	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007035
GO_process	GO:0008286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008286
GO_process	GO:0015991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015991
GO_process	GO:0016032	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016032
GO_process	GO:0016241	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016241
GO_process	GO:0033572	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033572
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0050690	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050690
GO_process	GO:0090383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090383
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0030234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
Gene3D	1.25.40.150	http://www.cathdb.info/version/latest/superfamily/1.25.40.150
GeneCards	ATP6V1H	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP6V1H
GeneID	51606	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51606
GeneTree	ENSGT00390000003289	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000003289
HGNC	HGNC:18303	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18303
HOGENOM	HOG000007240	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007240&db=HOGENOM6
HOVERGEN	HBG000459	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000459&db=HOVERGEN
HPA	CAB009532	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB009532
HPA	HPA023421	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA023421
InParanoid	Q9UI12	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UI12
IntAct	Q9UI12	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9UI12*
InterPro	IPR004908	http://www.ebi.ac.uk/interpro/entry/IPR004908
InterPro	IPR011987	http://www.ebi.ac.uk/interpro/entry/IPR011987
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
Jabion	51606	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=51606
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:51606	http://www.genome.jp/dbget-bin/www_bget?hsa:51606
KEGG_Orthology	KO:K02144	http://www.genome.jp/dbget-bin/www_bget?KO:K02144
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04142	http://www.genome.jp/kegg-bin/show_pathway?ko04142
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko05110	http://www.genome.jp/kegg-bin/show_pathway?ko05110
KEGG_Pathway	ko05120	http://www.genome.jp/kegg-bin/show_pathway?ko05120
KEGG_Pathway	ko05152	http://www.genome.jp/kegg-bin/show_pathway?ko05152
KEGG_Pathway	ko05323	http://www.genome.jp/kegg-bin/show_pathway?ko05323
MIM	608861	http://www.ncbi.nlm.nih.gov/omim/608861
MINT	MINT-5006690	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5006690
OMA	VIPNNEY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VIPNNEY
OrthoDB	EOG091G0NQW	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0NQW
PANTHER	PTHR10698	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10698
PSORT	swissprot:VATH_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VATH_HUMAN
PSORT-B	swissprot:VATH_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VATH_HUMAN
PSORT2	swissprot:VATH_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VATH_HUMAN
Pfam	PF11698	http://pfam.xfam.org/family/PF11698
PharmGKB	PA38521	http://www.pharmgkb.org/do/serve?objId=PA38521&objCls=Gene
Phobius	swissprot:VATH_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VATH_HUMAN
PhylomeDB	Q9UI12	http://phylomedb.org/?seqid=Q9UI12
ProteinModelPortal	Q9UI12	http://www.proteinmodelportal.org/query/uniprot/Q9UI12
PubMed	10810093	http://www.ncbi.nlm.nih.gov/pubmed/10810093
PubMed	10931946	http://www.ncbi.nlm.nih.gov/pubmed/10931946
PubMed	12032142	http://www.ncbi.nlm.nih.gov/pubmed/12032142
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25659576	http://www.ncbi.nlm.nih.gov/pubmed/25659576
PubMed	9620685	http://www.ncbi.nlm.nih.gov/pubmed/9620685
Reactome	R-HSA-1222556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1222556
Reactome	R-HSA-167590	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-167590
Reactome	R-HSA-182218	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-182218
Reactome	R-HSA-77387	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-77387
Reactome	R-HSA-917977	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917977
Reactome	R-HSA-983712	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983712
RefSeq	NP_057025	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_057025
RefSeq	NP_998784	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_998784
RefSeq	NP_998785	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_998785
RefSeq	XP_006716518	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006716518
STRING	9606.ENSP00000352522	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000352522&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
TCDB	3.A.2.2	http://www.tcdb.org/search/result.php?tc=3.A.2.2
UCSC	uc003xrl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003xrl&org=rat
UniGene	Hs.491737	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.491737
UniProtKB	VATH_HUMAN	http://www.uniprot.org/uniprot/VATH_HUMAN
UniProtKB-AC	Q9UI12	http://www.uniprot.org/uniprot/Q9UI12
charge	swissprot:VATH_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VATH_HUMAN
eggNOG	COG5231	http://eggnogapi.embl.de/nog_data/html/tree/COG5231
eggNOG	KOG2759	http://eggnogapi.embl.de/nog_data/html/tree/KOG2759
epestfind	swissprot:VATH_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VATH_HUMAN
garnier	swissprot:VATH_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VATH_HUMAN
helixturnhelix	swissprot:VATH_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VATH_HUMAN
hmoment	swissprot:VATH_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VATH_HUMAN
iep	swissprot:VATH_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VATH_HUMAN
inforesidue	swissprot:VATH_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VATH_HUMAN
neXtProt	NX_Q9UI12	http://www.nextprot.org/db/entry/NX_Q9UI12
octanol	swissprot:VATH_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VATH_HUMAN
pepcoil	swissprot:VATH_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VATH_HUMAN
pepdigest	swissprot:VATH_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VATH_HUMAN
pepinfo	swissprot:VATH_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VATH_HUMAN
pepnet	swissprot:VATH_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VATH_HUMAN
pepstats	swissprot:VATH_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VATH_HUMAN
pepwheel	swissprot:VATH_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VATH_HUMAN
pepwindow	swissprot:VATH_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VATH_HUMAN
sigcleave	swissprot:VATH_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VATH_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	125556	35
# DEVELOPMENTAL STAGE	Expressed meiotically and post-meiotically. {ECO:0000269|PubMed	16625279}. 
# DISEASE	CTSR1_HUMAN	Spermatogenic failure 7 (SPGF7) [MIM 612997]  An infertility disorder characterized by non-motile sperm or sperm motility below the normal threshold, low sperm count, increased abnormally structured spermatozoa, and reduced semen volume. {ECO 0000269|PubMed 19344877}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# ENZYME REGULATION	CTSR1_HUMAN	The CatSper calcium channel is indirectly activated by extracellular progesterone and prostaglandins following the sequence  progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2 (PubMed 21412338, PubMed 21412339, PubMed 26989199). The CatSper calcium channel is directly inhibited by endocannabinoid 2-arachidonoylglycerol (2AG) (PubMed 26989199). Indirect activation by progesterone takes place via the following mechanism  progesterone binds and activates the acylglycerol lipase ABHD2, which in turn mediates hydrolysis of 2AG inhibitor, relieving inhibition of the CatSper channel (PubMed 26989199). The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers (PubMed 21412338, PubMed 21412339). Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH (PubMed 21412338, PubMed 21412339). {ECO 0000269|PubMed 21412338, ECO 0000269|PubMed 21412339, ECO 0000269|PubMed 26989199}. 
# Ensembl	ENST00000312106	ENSP00000309052; ENSG00000175294
# FUNCTION	CTSR1_HUMAN	Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. {ECO 0000269|PubMed 21412338, ECO 0000269|PubMed 21412339}. 
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0031514	motile cilium; IEA:UniProtKB-KW.
# GO_component	GO:0036128	CatSper complex; ISS:UniProtKB.
# GO_function	GO:0005227	calcium activated cation channel activity; IEA:InterPro.
# GO_function	GO:0005245	voltage-gated calcium channel activity; IBA:GO_Central.
# GO_process	GO:0007275	multicellular organism development; IEA:UniProtKB-KW.
# GO_process	GO:0007283	spermatogenesis; IEA:UniProtKB-KW.
# GO_process	GO:0007342	fusion of sperm to egg plasma membrane; IEA:Ensembl.
# GO_process	GO:0030154	cell differentiation; IEA:UniProtKB-KW.
# GO_process	GO:0030317	flagellated sperm motility; IBA:GO_Central.
# GO_process	GO:0032570	response to progesterone; TAS:Reactome.
# GO_process	GO:0035036	sperm-egg recognition; TAS:Reactome.
# GO_process	GO:0051924	regulation of calcium ion transport; IEA:Ensembl.
# GO_process	GO:0060296	regulation of cilium beat frequency involved in ciliary motility; IEA:Ensembl.
# GO_process	GO:0086010	membrane depolarization during action potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0005929	cilium
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0048870	cell motility
# GOslim_process	GO:0061024	membrane organization
# Gene3D	1.20.120.350	-; 1.
# Genevisible	Q8NEC5	HS
# HGNC	HGNC:17116	CATSPER1
# INDUCTION	Down-regulated in patients lacking sperm motility. {ECO:0000269|PubMed	14688170}. 
# INTERACTION	CTSR1_HUMAN	O95994 AGR2; NbExp=3; IntAct=EBI-744545, EBI-712648; P02652 APOA2; NbExp=5; IntAct=EBI-744545, EBI-1171525; Q9P0X4 CACNA1I; NbExp=5; IntAct=EBI-744545, EBI-1220829; Q9H2X0 CHRD; NbExp=3; IntAct=EBI-744545, EBI-947551; P50402 EMD; NbExp=3; IntAct=EBI-744545, EBI-489887; Q5VWX1 KHDRBS2; NbExp=5; IntAct=EBI-744545, EBI-742808; Q5T749 KPRP; NbExp=4; IntAct=EBI-744545, EBI-10981970; P60412 KRTAP10-11; NbExp=3; IntAct=EBI-744545, EBI-10217483; P60410 KRTAP10-8; NbExp=9; IntAct=EBI-744545, EBI-10171774; P60411 KRTAP10-9; NbExp=7; IntAct=EBI-744545, EBI-10172052; P60328 KRTAP12-3; NbExp=4; IntAct=EBI-744545, EBI-11953334; Q9BYQ6 KRTAP4-11; NbExp=3; IntAct=EBI-744545, EBI-10302392; Q9BQ66 KRTAP4-12; NbExp=8; IntAct=EBI-744545, EBI-739863; Q9BYR0 KRTAP4-7; NbExp=3; IntAct=EBI-744545, EBI-10302547; Q6L8G9 KRTAP5-6; NbExp=3; IntAct=EBI-744545, EBI-10250562; P26371 KRTAP5-9; NbExp=7; IntAct=EBI-744545, EBI-3958099; Q9BYQ4 KRTAP9-2; NbExp=9; IntAct=EBI-744545, EBI-1044640; Q9BYQ3 KRTAP9-3; NbExp=4; IntAct=EBI-744545, EBI-1043191; Q9BYQ2 KRTAP9-4; NbExp=3; IntAct=EBI-744545, EBI-10185730; Q99750 MDFI; NbExp=3; IntAct=EBI-744545, EBI-724076; Q5JR59 MTUS2; NbExp=3; IntAct=EBI-744545, EBI-742948; Q7Z3S9 NOTCH2NL; NbExp=5; IntAct=EBI-744545, EBI-945833; O15162 PLSCR1; NbExp=3; IntAct=EBI-744545, EBI-740019; Q9NRY6 PLSCR3; NbExp=5; IntAct=EBI-744545, EBI-750734; Q8HWS3 RFX6; NbExp=5; IntAct=EBI-744545, EBI-746118; O76081 RGS20; NbExp=4; IntAct=EBI-744545, EBI-1052678; Q9UFD9 RIMBP3; NbExp=3; IntAct=EBI-744545, EBI-10182375; O75711 SCRG1; NbExp=3; IntAct=EBI-744545, EBI-10189029; O43597 SPRY2; NbExp=3; IntAct=EBI-744545, EBI-742487; Q12933 TRAF2; NbExp=3; IntAct=EBI-744545, EBI-355744; Q15654 TRIP6; NbExp=6; IntAct=EBI-744545, EBI-742327; 
# IntAct	Q8NEC5	71
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028746	CatSper1
# KEGG_Disease	H01282	[Developmental disorder] Spermatogenic failure
# MIM	606389	gene
# MIM	612997	phenotype
# Organism	CTSR1_HUMAN	Homo sapiens (Human)
# Orphanet	276234	Non-syndromic male infertility due to sperm motility disorder
# PANTHER	PTHR10037:SF216	PTHR10037:SF216; 3
# Pfam	PF00520	Ion_trans
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-1300642	Sperm Motility And Taxes
# RecName	CTSR1_HUMAN	Cation channel sperm-associated protein 1
# RefSeq	NP_444282	NM_053054.3
# SIMILARITY	Belongs to the cation channel sperm-associated (TC 1.A.1.19) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	CTSR1_HUMAN	Cell projection, cilium, flagellum membrane {ECO 0000269|PubMed 16625279}; Multi-pass membrane protein {ECO 0000269|PubMed 16625279}. Note=Specifically located in the principal piece of sperm tail. 
# SUBUNIT	CTSR1_HUMAN	Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Component of the CatSper complex. Interacts with CATSPER3 and CATSPER4 (By similarity). Interacts with Ca(v)3.3/CACNA1I, leading to suppress T-type calcium channel activity. {ECO 0000250, ECO 0000269|PubMed 16740636, ECO 0000305}. 
# TCDB	1.A.1.19	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	CTSR1_HUMAN	Testis-specific. {ECO 0000269|PubMed 11595941, ECO 0000269|PubMed 16625279, ECO 0000269|PubMed 17347248}. 
# UCSC	uc001ogt	human
# eggNOG	ENOG410XNP6	LUCA
# eggNOG	KOG2302	Eukaryota
BLAST	swissprot:CTSR1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CTSR1_HUMAN
BioCyc	ZFISH:ENSG00000175294-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000175294-MONOMER
COXPRESdb	117144	http://coxpresdb.jp/data/gene/117144.shtml
CleanEx	HS_CATSPER1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CATSPER1
DOI	10.1016/j.ajhg.2009.03.004	http://dx.doi.org/10.1016/j.ajhg.2009.03.004
DOI	10.1038/35098027	http://dx.doi.org/10.1038/35098027
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1038/nature09767	http://dx.doi.org/10.1038/nature09767
DOI	10.1038/nature09769	http://dx.doi.org/10.1038/nature09769
DOI	10.1074/jbc.M511288200	http://dx.doi.org/10.1074/jbc.M511288200
DOI	10.1093/humrep/deh043	http://dx.doi.org/10.1093/humrep/deh043
DOI	10.1093/molehr/gam009	http://dx.doi.org/10.1093/molehr/gam009
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1745-7262.2006.00132.x	http://dx.doi.org/10.1111/j.1745-7262.2006.00132.x
DOI	10.1126/science.aad6887	http://dx.doi.org/10.1126/science.aad6887
EMBL	AF407333	http://www.ebi.ac.uk/ena/data/view/AF407333
EMBL	AP006287	http://www.ebi.ac.uk/ena/data/view/AP006287
EMBL	BC032950	http://www.ebi.ac.uk/ena/data/view/BC032950
EMBL	BC036522	http://www.ebi.ac.uk/ena/data/view/BC036522
Ensembl	ENST00000312106	http://www.ensembl.org/id/ENST00000312106
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0031514	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031514
GO_component	GO:0036128	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036128
GO_function	GO:0005227	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005227
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_process	GO:0007275	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007275
GO_process	GO:0007283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007283
GO_process	GO:0007342	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007342
GO_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GO_process	GO:0030317	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030317
GO_process	GO:0032570	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032570
GO_process	GO:0035036	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035036
GO_process	GO:0051924	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051924
GO_process	GO:0060296	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060296
GO_process	GO:0086010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086010
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0005929	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005929
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	CATSPER1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CATSPER1
GeneID	117144	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=117144
GeneTree	ENSGT00830000128247	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00830000128247
H-InvDB	HIX0201680	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0201680
HGNC	HGNC:17116	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17116
HOGENOM	HOG000112051	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000112051&db=HOGENOM6
HOVERGEN	HBG098336	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG098336&db=HOVERGEN
InParanoid	Q8NEC5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8NEC5
IntAct	Q8NEC5	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8NEC5*
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028746	http://www.ebi.ac.uk/interpro/entry/IPR028746
Jabion	117144	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=117144
KEGG_Disease	H01282	http://www.genome.jp/dbget-bin/www_bget?H01282
KEGG_Gene	hsa:117144	http://www.genome.jp/dbget-bin/www_bget?hsa:117144
MIM	606389	http://www.ncbi.nlm.nih.gov/omim/606389
MIM	612997	http://www.ncbi.nlm.nih.gov/omim/612997
MINT	MINT-1453027	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1453027
OMA	VCLNTIM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VCLNTIM
Orphanet	276234	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=276234
OrthoDB	EOG091G0KAS	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0KAS
PANTHER	PTHR10037:SF216	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10037:SF216
PSORT	swissprot:CTSR1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CTSR1_HUMAN
PSORT-B	swissprot:CTSR1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CTSR1_HUMAN
PSORT2	swissprot:CTSR1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CTSR1_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
PharmGKB	PA38438	http://www.pharmgkb.org/do/serve?objId=PA38438&objCls=Gene
Phobius	swissprot:CTSR1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CTSR1_HUMAN
PhylomeDB	Q8NEC5	http://phylomedb.org/?seqid=Q8NEC5
ProteinModelPortal	Q8NEC5	http://www.proteinmodelportal.org/query/uniprot/Q8NEC5
PubMed	11595941	http://www.ncbi.nlm.nih.gov/pubmed/11595941
PubMed	14688170	http://www.ncbi.nlm.nih.gov/pubmed/14688170
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	16625279	http://www.ncbi.nlm.nih.gov/pubmed/16625279
PubMed	16740636	http://www.ncbi.nlm.nih.gov/pubmed/16740636
PubMed	17347248	http://www.ncbi.nlm.nih.gov/pubmed/17347248
PubMed	19344877	http://www.ncbi.nlm.nih.gov/pubmed/19344877
PubMed	21412338	http://www.ncbi.nlm.nih.gov/pubmed/21412338
PubMed	21412339	http://www.ncbi.nlm.nih.gov/pubmed/21412339
PubMed	26989199	http://www.ncbi.nlm.nih.gov/pubmed/26989199
Reactome	R-HSA-1300642	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1300642
RefSeq	NP_444282	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_444282
STRING	9606.ENSP00000309052	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000309052&targetmode=cogs
TCDB	1.A.1.19	http://www.tcdb.org/search/result.php?tc=1.A.1.19
UCSC	uc001ogt	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001ogt&org=rat
UniGene	Hs.189105	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.189105
UniProtKB	CTSR1_HUMAN	http://www.uniprot.org/uniprot/CTSR1_HUMAN
UniProtKB-AC	Q8NEC5	http://www.uniprot.org/uniprot/Q8NEC5
charge	swissprot:CTSR1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CTSR1_HUMAN
eggNOG	ENOG410XNP6	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNP6
eggNOG	KOG2302	http://eggnogapi.embl.de/nog_data/html/tree/KOG2302
epestfind	swissprot:CTSR1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CTSR1_HUMAN
garnier	swissprot:CTSR1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CTSR1_HUMAN
helixturnhelix	swissprot:CTSR1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CTSR1_HUMAN
hmoment	swissprot:CTSR1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CTSR1_HUMAN
iep	swissprot:CTSR1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CTSR1_HUMAN
inforesidue	swissprot:CTSR1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CTSR1_HUMAN
neXtProt	NX_Q8NEC5	http://www.nextprot.org/db/entry/NX_Q8NEC5
octanol	swissprot:CTSR1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CTSR1_HUMAN
pepcoil	swissprot:CTSR1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CTSR1_HUMAN
pepdigest	swissprot:CTSR1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CTSR1_HUMAN
pepinfo	swissprot:CTSR1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CTSR1_HUMAN
pepnet	swissprot:CTSR1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CTSR1_HUMAN
pepstats	swissprot:CTSR1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CTSR1_HUMAN
pepwheel	swissprot:CTSR1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CTSR1_HUMAN
pepwindow	swissprot:CTSR1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CTSR1_HUMAN
sigcleave	swissprot:CTSR1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CTSR1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	P2RX2_HUMAN	Event=Alternative splicing; Named isoforms=7; Name=A; IsoId=Q9UBL9-1; Sequence=Displayed; Name=B; IsoId=Q9UBL9-2; Sequence=VSP_004499; Name=C; IsoId=Q9UBL9-3; Sequence=VSP_004497; Name=D; IsoId=Q9UBL9-4; Sequence=VSP_004498; Name=H; IsoId=Q9UBL9-5; Sequence=VSP_004495; Name=I; IsoId=Q9UBL9-6; Sequence=VSP_004496; Name=K; IsoId=Q9UBL9-7; Sequence=VSP_004497, VSP_014135, VSP_004499; Note=No experimental confirmation available.; 
# AltName	P2RX2_HUMAN	ATP receptor
# AltName	P2RX2_HUMAN	Purinergic receptor
# BioGrid	116607	21
# CCDS	CCDS31930	-. [Q9UBL9-4]
# CCDS	CCDS31931	-. [Q9UBL9-1]
# CCDS	CCDS31932	-. [Q9UBL9-2]
# CCDS	CCDS31933	-. [Q9UBL9-3]
# CCDS	CCDS31934	-. [Q9UBL9-6]
# CCDS	CCDS31935	-. [Q9UBL9-5]
# CCDS	CCDS61286	-. [Q9UBL9-7]
# DISEASE	P2RX2_HUMAN	Deafness, autosomal dominant, 41 (DFNA41) [MIM 608224]  A form of non-syndromic deafness characterized by onset of progressive sensorineural hearing loss usually in the second decade. The hearing loss is severe and ultimately affects all frequencies. Exposure to noise exacerbates the hearing loss, particularly at high frequencies. {ECO 0000269|PubMed 23345450, ECO 0000269|PubMed 24211385}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000343948	ENSP00000343339; ENSG00000187848. [Q9UBL9-4]
# Ensembl	ENST00000348800	ENSP00000345095; ENSG00000187848. [Q9UBL9-2]
# Ensembl	ENST00000350048	ENSP00000343904; ENSG00000187848. [Q9UBL9-3]
# Ensembl	ENST00000351222	ENSP00000344502; ENSG00000187848. [Q9UBL9-5]
# Ensembl	ENST00000352418	ENSP00000341419; ENSG00000187848. [Q9UBL9-6]
# Ensembl	ENST00000389110	ENSP00000373762; ENSG00000187848. [Q9UBL9-1]
# Ensembl	ENST00000449132	ENSP00000405531; ENSG00000187848. [Q9UBL9-7]
# ExpressionAtlas	Q9UBL9	baseline and differential
# FUNCTION	P2RX2_HUMAN	Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle. {ECO 0000269|PubMed 23345450}. 
# GO_component	GO:0005639	integral component of nuclear inner membrane; IBA:GO_Central.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_component	GO:0043235	receptor complex; IDA:MGI.
# GO_function	GO:0001614	purinergic nucleotide receptor activity; NAS:BHF-UCL.
# GO_function	GO:0004931	extracellular ATP-gated cation channel activity; IDA:UniProtKB.
# GO_function	GO:0005524	ATP binding; NAS:BHF-UCL.
# GO_function	GO:0015276	ligand-gated ion channel activity; TAS:ProtInc.
# GO_function	GO:0042802	identical protein binding; IPI:BHF-UCL.
# GO_process	GO:0001666	response to hypoxia; IEA:Ensembl.
# GO_process	GO:0003029	detection of hypoxic conditions in blood by carotid body chemoreceptor signaling; IEA:Ensembl.
# GO_process	GO:0007274	neuromuscular synaptic transmission; IEA:Ensembl.
# GO_process	GO:0007528	neuromuscular junction development; IEA:Ensembl.
# GO_process	GO:0007596	blood coagulation; TAS:Reactome.
# GO_process	GO:0007605	sensory perception of sound; IMP:UniProtKB.
# GO_process	GO:0009743	response to carbohydrate; IEA:Ensembl.
# GO_process	GO:0010524	positive regulation of calcium ion transport into cytosol; NAS:BHF-UCL.
# GO_process	GO:0014832	urinary bladder smooth muscle contraction; IEA:Ensembl.
# GO_process	GO:0030432	peristalsis; IEA:Ensembl.
# GO_process	GO:0033198	response to ATP; IEA:Ensembl.
# GO_process	GO:0048266	behavioral response to pain; IEA:Ensembl.
# GO_process	GO:0048741	skeletal muscle fiber development; IEA:Ensembl.
# GO_process	GO:0050850	positive regulation of calcium-mediated signaling; NAS:BHF-UCL.
# GO_process	GO:0050909	sensory perception of taste; IEA:Ensembl.
# GO_process	GO:0051260	protein homooligomerization; IPI:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# Gene3D	2.60.490.10	-; 1.
# Genevisible	Q9UBL9	HS
# HGNC	HGNC:15459	P2RX2
# InterPro	IPR001429	P2X_purnocptor
# InterPro	IPR003045	P2X2_purnocptor
# InterPro	IPR027309	P2X_extracellular_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# MIM	600844	gene
# MIM	608224	phenotype
# Organism	P2RX2_HUMAN	Homo sapiens (Human)
# Orphanet	90635	Autosomal dominant non-syndromic sensorineural deafness type DFNA
# PANTHER	PTHR10125	PTHR10125
# PANTHER	PTHR10125:SF4	PTHR10125:SF4
# PIRSF	PIRSF005713	P2X_purinoceptor
# PRINTS	PR01307	P2XRECEPTOR
# PRINTS	PR01309	P2X2RECEPTOR
# PROSITE	PS01212	P2X_RECEPTOR
# Pfam	PF00864	P2X_receptor
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-139853	Elevation of cytosolic Ca2+ levels
# Reactome	R-HSA-418346	Platelet homeostasis
# RecName	P2RX2_HUMAN	P2X purinoceptor 2
# RefSeq	NP_001269093	NM_001282164.1. [Q9UBL9-7]
# RefSeq	NP_001269094	NM_001282165.1
# RefSeq	NP_036358	NM_012226.4. [Q9UBL9-6]
# RefSeq	NP_057402	NM_016318.3. [Q9UBL9-3]
# RefSeq	NP_733782	NM_170682.3. [Q9UBL9-1]
# RefSeq	NP_733783	NM_170683.3. [Q9UBL9-4]
# RefSeq	NP_777361	NM_174872.2. [Q9UBL9-5]
# RefSeq	NP_777362	NM_174873.2. [Q9UBL9-2]
# SIMILARITY	Belongs to the P2X receptor family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	P2RX2_HUMAN	Cell membrane {ECO 0000269|PubMed 23345450}; Multi-pass membrane protein {ECO 0000269|PubMed 23345450}. Note=Localizes to the apical membranes of hair cells in the organ of Corti. 
# SUBUNIT	P2RX2_HUMAN	Homotrimer and heterotrimer; functional P2XRs are organized as homomeric and heteromeric trimers. 
# TIGRFAMs	TIGR00863	P2X
# UCSC	uc001uki	human. [Q9UBL9-1]
# WEB RESOURCE	P2RX2_HUMAN	Name=Wikipedia; Note=P2X receptor entry; URL="https //en.wikipedia.org/wiki/P2X_receptor";
BLAST	swissprot:P2RX2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:P2RX2_HUMAN
BioCyc	ZFISH:ENSG00000177026-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000177026-MONOMER
COXPRESdb	22953	http://coxpresdb.jp/data/gene/22953.shtml
DOI	10.1016/j.gene.2013.10.052	http://dx.doi.org/10.1016/j.gene.2013.10.052
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1073/pnas.1222285110	http://dx.doi.org/10.1073/pnas.1222285110
EMBL	AC131212	http://www.ebi.ac.uk/ena/data/view/AC131212
EMBL	AF109387	http://www.ebi.ac.uk/ena/data/view/AF109387
EMBL	AF109388	http://www.ebi.ac.uk/ena/data/view/AF109388
EMBL	AF190822	http://www.ebi.ac.uk/ena/data/view/AF190822
EMBL	AF190823	http://www.ebi.ac.uk/ena/data/view/AF190823
EMBL	AF190824	http://www.ebi.ac.uk/ena/data/view/AF190824
EMBL	AF190825	http://www.ebi.ac.uk/ena/data/view/AF190825
EMBL	AF190826	http://www.ebi.ac.uk/ena/data/view/AF190826
EMBL	AF260426	http://www.ebi.ac.uk/ena/data/view/AF260426
EMBL	AF260427	http://www.ebi.ac.uk/ena/data/view/AF260427
EMBL	AF260428	http://www.ebi.ac.uk/ena/data/view/AF260428
EMBL	AF260429	http://www.ebi.ac.uk/ena/data/view/AF260429
EMBL	AY346374	http://www.ebi.ac.uk/ena/data/view/AY346374
Ensembl	ENST00000343948	http://www.ensembl.org/id/ENST00000343948
Ensembl	ENST00000348800	http://www.ensembl.org/id/ENST00000348800
Ensembl	ENST00000350048	http://www.ensembl.org/id/ENST00000350048
Ensembl	ENST00000351222	http://www.ensembl.org/id/ENST00000351222
Ensembl	ENST00000352418	http://www.ensembl.org/id/ENST00000352418
Ensembl	ENST00000389110	http://www.ensembl.org/id/ENST00000389110
Ensembl	ENST00000449132	http://www.ensembl.org/id/ENST00000449132
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005639	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005639
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0043235	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043235
GO_function	GO:0001614	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001614
GO_function	GO:0004931	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004931
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_function	GO:0042802	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802
GO_process	GO:0001666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001666
GO_process	GO:0003029	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003029
GO_process	GO:0007274	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007274
GO_process	GO:0007528	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007528
GO_process	GO:0007596	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007596
GO_process	GO:0007605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007605
GO_process	GO:0009743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009743
GO_process	GO:0010524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010524
GO_process	GO:0014832	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014832
GO_process	GO:0030432	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030432
GO_process	GO:0033198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033198
GO_process	GO:0048266	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048266
GO_process	GO:0048741	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048741
GO_process	GO:0050850	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050850
GO_process	GO:0050909	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050909
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
Gene3D	2.60.490.10	http://www.cathdb.info/version/latest/superfamily/2.60.490.10
GeneCards	P2RX2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=P2RX2
GeneID	22953	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22953
GeneTree	ENSGT00390000016028	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000016028
HGNC	HGNC:15459	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:15459
HOVERGEN	HBG053086	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053086&db=HOVERGEN
HPA	HPA014025	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014025
InParanoid	Q9UBL9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UBL9
InterPro	IPR001429	http://www.ebi.ac.uk/interpro/entry/IPR001429
InterPro	IPR003045	http://www.ebi.ac.uk/interpro/entry/IPR003045
InterPro	IPR027309	http://www.ebi.ac.uk/interpro/entry/IPR027309
Jabion	22953	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=22953
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:22953	http://www.genome.jp/dbget-bin/www_bget?hsa:22953
KEGG_Orthology	KO:K05216	http://www.genome.jp/dbget-bin/www_bget?KO:K05216
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
MIM	600844	http://www.ncbi.nlm.nih.gov/omim/600844
MIM	608224	http://www.ncbi.nlm.nih.gov/omim/608224
OMA	LYFVWYV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LYFVWYV
Orphanet	90635	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=90635
OrthoDB	EOG091G0A2U	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0A2U
PANTHER	PTHR10125	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10125
PANTHER	PTHR10125:SF4	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10125:SF4
PRINTS	PR01307	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01307
PRINTS	PR01309	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01309
PROSITE	PS01212	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01212
PSORT	swissprot:P2RX2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:P2RX2_HUMAN
PSORT-B	swissprot:P2RX2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:P2RX2_HUMAN
PSORT2	swissprot:P2RX2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:P2RX2_HUMAN
Pfam	PF00864	http://pfam.xfam.org/family/PF00864
PharmGKB	PA32862	http://www.pharmgkb.org/do/serve?objId=PA32862&objCls=Gene
Phobius	swissprot:P2RX2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:P2RX2_HUMAN
PhylomeDB	Q9UBL9	http://phylomedb.org/?seqid=Q9UBL9
ProteinModelPortal	Q9UBL9	http://www.proteinmodelportal.org/query/uniprot/Q9UBL9
PubMed	10570044	http://www.ncbi.nlm.nih.gov/pubmed/10570044
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	23345450	http://www.ncbi.nlm.nih.gov/pubmed/23345450
PubMed	24211385	http://www.ncbi.nlm.nih.gov/pubmed/24211385
Reactome	R-HSA-139853	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-139853
Reactome	R-HSA-418346	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418346
RefSeq	NP_001269093	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269093
RefSeq	NP_001269094	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269094
RefSeq	NP_036358	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_036358
RefSeq	NP_057402	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_057402
RefSeq	NP_733782	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_733782
RefSeq	NP_733783	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_733783
RefSeq	NP_777361	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_777361
RefSeq	NP_777362	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_777362
SMR	Q9UBL9	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9UBL9
TIGRFAMs	TIGR00863	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00863
UCSC	uc001uki	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001uki&org=rat
UniGene	Hs.258580	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.258580
UniProtKB	P2RX2_HUMAN	http://www.uniprot.org/uniprot/P2RX2_HUMAN
UniProtKB-AC	Q9UBL9	http://www.uniprot.org/uniprot/Q9UBL9
charge	swissprot:P2RX2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:P2RX2_HUMAN
epestfind	swissprot:P2RX2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:P2RX2_HUMAN
garnier	swissprot:P2RX2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:P2RX2_HUMAN
helixturnhelix	swissprot:P2RX2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:P2RX2_HUMAN
hmoment	swissprot:P2RX2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:P2RX2_HUMAN
iep	swissprot:P2RX2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:P2RX2_HUMAN
inforesidue	swissprot:P2RX2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:P2RX2_HUMAN
neXtProt	NX_Q9UBL9	http://www.nextprot.org/db/entry/NX_Q9UBL9
octanol	swissprot:P2RX2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:P2RX2_HUMAN
pepcoil	swissprot:P2RX2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:P2RX2_HUMAN
pepdigest	swissprot:P2RX2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:P2RX2_HUMAN
pepinfo	swissprot:P2RX2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:P2RX2_HUMAN
pepnet	swissprot:P2RX2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:P2RX2_HUMAN
pepstats	swissprot:P2RX2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:P2RX2_HUMAN
pepwheel	swissprot:P2RX2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:P2RX2_HUMAN
pepwindow	swissprot:P2RX2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:P2RX2_HUMAN
sigcleave	swissprot:P2RX2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:P2RX2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AT134_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q4VNC1-1; Sequence=Displayed; Name=2; IsoId=Q4VNC1-2; Sequence=VSP_031261; Note=Dubious isoform lacking mature mRNA evidence.; Name=3; IsoId=Q4VNC1-3; Sequence=VSP_031259, VSP_031260; Note=No experimental confirmation available.; Name=4; IsoId=Q4VNC1-4; Sequence=VSP_031258; Note=No experimental confirmation available.; 
# AltName	AT134_HUMAN	P5-ATPase isoform 4
# CATALYTIC ACTIVITY	AT134_HUMAN	ATP + H(2)O = ADP + phosphate. 
# CCDS	CCDS3304	-. [Q4VNC1-1]
# DISEASE	AT134_HUMAN	Note=A chromosomal aberration involving ATP13A4 is found in 2 patients with specific language impairment (SLI) disorders. Paracentric inversion inv(3)(q25;q29). The inversion produces a disruption of the protein. {ECO 0000269|PubMed 15925480}. 
# Ensembl	ENST00000295548	ENSP00000295548; ENSG00000127249. [Q4VNC1-3]
# Ensembl	ENST00000342695	ENSP00000339182; ENSG00000127249. [Q4VNC1-1]
# Ensembl	ENST00000400270	ENSP00000383129; ENSG00000127249. [Q4VNC1-4]
# ExpressionAtlas	Q4VNC1	baseline and differential
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IBA:GO_Central.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0019829	cation-transporting ATPase activity; IBA:GO_Central.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0006874	cellular calcium ion homeostasis; IBA:GO_Central.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.70.150.10	-; 1.
# Gene3D	3.40.1110.10	-; 1.
# Gene3D	3.40.50.1000	-; 2.
# Genevisible	Q4VNC1	HS
# HGNC	HGNC:25422	ATP13A4
# INDUCTION	Decreased by half in the SLI patient lymphoblasts. {ECO:0000269|PubMed	15925480}. 
# InterPro	IPR001757	P_typ_ATPase
# InterPro	IPR004014	ATPase_P-typ_cation-transptr_N
# InterPro	IPR006544	P-type_TPase_V
# InterPro	IPR008250	ATPase_P-typ_transduc_dom_A
# InterPro	IPR018303	ATPase_P-typ_P_site
# InterPro	IPR023214	HAD-like_dom
# InterPro	IPR023299	ATPase_P-typ_cyto_domN
# KEGG_Brite	ko01000	Enzymes
# MIM	609556	gene
# Organism	AT134_HUMAN	Homo sapiens (Human)
# PROSITE	PS00154	ATPASE_E1_E2
# Pfam	PF00122	E1-E2_ATPase
# Pfam	PF00690	Cation_ATPase_N
# Pfam	PF12409	P5-ATPase
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	AT134_HUMAN	Probable cation-transporting ATPase 13A4
# RefSeq	NP_115655	NM_032279.3. [Q4VNC1-1]
# SEQUENCE CAUTION	Sequence=CAC21667.2; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. {ECO	0000305}. 
# SMART	SM00831	Cation_ATPase_N
# SUBCELLULAR LOCATION	AT134_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF56784	SSF56784; 3
# SUPFAM	SSF81660	SSF81660
# TIGRFAMs	TIGR01494	ATPase_P-type; 3
# TIGRFAMs	TIGR01657	P-ATPase-V
# TISSUE SPECIFICITY	Expressed in heart, placenta, liver, skeletal muscles, and pancreas. Lower levels of expression are also detected in brain, lung and kidney. Weakly expressed in the adult brain. Expression in fetal brain is higher than in adult brain, with levels similar to several other fetal tissues including spleen and skeletal muscle. In adult brain expressed at low levels in all tissues examined, including the temporal lobe and putamen. {ECO:0000269|PubMed	15925480}. 
# UCSC	uc003ftd	human. [Q4VNC1-1]
# eggNOG	ENOG410XRCA	LUCA
# eggNOG	KOG0208	Eukaryota
BLAST	swissprot:AT134_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AT134_HUMAN
COXPRESdb	84239	http://coxpresdb.jp/data/gene/84239.shtml
CleanEx	HS_ATP13A4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP13A4
DOI	10.1016/j.ygeno.2005.04.002	http://dx.doi.org/10.1016/j.ygeno.2005.04.002
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EC_number	EC:3.6.3.-	http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.-
EMBL	AC048351	http://www.ebi.ac.uk/ena/data/view/AC048351
EMBL	AC092942	http://www.ebi.ac.uk/ena/data/view/AC092942
EMBL	AC105057	http://www.ebi.ac.uk/ena/data/view/AC105057
EMBL	AK095277	http://www.ebi.ac.uk/ena/data/view/AK095277
EMBL	AL512736	http://www.ebi.ac.uk/ena/data/view/AL512736
EMBL	AY358110	http://www.ebi.ac.uk/ena/data/view/AY358110
EMBL	AY823162	http://www.ebi.ac.uk/ena/data/view/AY823162
EMBL	BC101496	http://www.ebi.ac.uk/ena/data/view/BC101496
ENZYME	3.6.3.-	http://enzyme.expasy.org/EC/3.6.3.-
Ensembl	ENST00000295548	http://www.ensembl.org/id/ENST00000295548
Ensembl	ENST00000342695	http://www.ensembl.org/id/ENST00000342695
Ensembl	ENST00000400270	http://www.ensembl.org/id/ENST00000400270
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0019829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019829
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.70.150.10	http://www.cathdb.info/version/latest/superfamily/2.70.150.10
Gene3D	3.40.1110.10	http://www.cathdb.info/version/latest/superfamily/3.40.1110.10
Gene3D	3.40.50.1000	http://www.cathdb.info/version/latest/superfamily/3.40.50.1000
GeneCards	ATP13A4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP13A4
GeneID	84239	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84239
GeneTree	ENSGT00530000063001	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063001
HGNC	HGNC:25422	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:25422
HOGENOM	HOG000171813	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000171813&db=HOGENOM6
HOVERGEN	HBG065757	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG065757&db=HOVERGEN
HPA	HPA051932	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA051932
InParanoid	Q4VNC1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q4VNC1
IntAct	Q4VNC1	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q4VNC1*
IntEnz	3.6.3	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3
InterPro	IPR001757	http://www.ebi.ac.uk/interpro/entry/IPR001757
InterPro	IPR004014	http://www.ebi.ac.uk/interpro/entry/IPR004014
InterPro	IPR006544	http://www.ebi.ac.uk/interpro/entry/IPR006544
InterPro	IPR008250	http://www.ebi.ac.uk/interpro/entry/IPR008250
InterPro	IPR018303	http://www.ebi.ac.uk/interpro/entry/IPR018303
InterPro	IPR023214	http://www.ebi.ac.uk/interpro/entry/IPR023214
InterPro	IPR023299	http://www.ebi.ac.uk/interpro/entry/IPR023299
Jabion	84239	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=84239
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:84239	http://www.genome.jp/dbget-bin/www_bget?hsa:84239
KEGG_Orthology	KO:K14951	http://www.genome.jp/dbget-bin/www_bget?KO:K14951
MIM	609556	http://www.ncbi.nlm.nih.gov/omim/609556
OMA	GALEDHH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GALEDHH
OrthoDB	EOG091G01IL	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01IL
PROSITE	PS00154	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00154
PSORT	swissprot:AT134_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AT134_HUMAN
PSORT-B	swissprot:AT134_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AT134_HUMAN
PSORT2	swissprot:AT134_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AT134_HUMAN
Pfam	PF00122	http://pfam.xfam.org/family/PF00122
Pfam	PF00690	http://pfam.xfam.org/family/PF00690
Pfam	PF12409	http://pfam.xfam.org/family/PF12409
PharmGKB	PA134979581	http://www.pharmgkb.org/do/serve?objId=PA134979581&objCls=Gene
Phobius	swissprot:AT134_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AT134_HUMAN
PhylomeDB	Q4VNC1	http://phylomedb.org/?seqid=Q4VNC1
ProteinModelPortal	Q4VNC1	http://www.proteinmodelportal.org/query/uniprot/Q4VNC1
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15925480	http://www.ncbi.nlm.nih.gov/pubmed/15925480
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_115655	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_115655
SMART	SM00831	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00831
STRING	9606.ENSP00000339182	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000339182&targetmode=cogs
SUPFAM	SSF56784	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784
SUPFAM	SSF81660	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81660
TIGRFAMs	TIGR01494	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01494
TIGRFAMs	TIGR01657	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01657
UCSC	uc003ftd	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ftd&org=rat
UniGene	Hs.674423	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.674423
UniProtKB	AT134_HUMAN	http://www.uniprot.org/uniprot/AT134_HUMAN
UniProtKB-AC	Q4VNC1	http://www.uniprot.org/uniprot/Q4VNC1
charge	swissprot:AT134_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AT134_HUMAN
eggNOG	ENOG410XRCA	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRCA
eggNOG	KOG0208	http://eggnogapi.embl.de/nog_data/html/tree/KOG0208
epestfind	swissprot:AT134_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AT134_HUMAN
garnier	swissprot:AT134_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AT134_HUMAN
helixturnhelix	swissprot:AT134_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AT134_HUMAN
hmoment	swissprot:AT134_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AT134_HUMAN
iep	swissprot:AT134_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AT134_HUMAN
inforesidue	swissprot:AT134_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AT134_HUMAN
neXtProt	NX_Q4VNC1	http://www.nextprot.org/db/entry/NX_Q4VNC1
octanol	swissprot:AT134_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AT134_HUMAN
pepcoil	swissprot:AT134_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AT134_HUMAN
pepdigest	swissprot:AT134_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AT134_HUMAN
pepinfo	swissprot:AT134_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AT134_HUMAN
pepnet	swissprot:AT134_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AT134_HUMAN
pepstats	swissprot:AT134_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AT134_HUMAN
pepwheel	swissprot:AT134_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AT134_HUMAN
pepwindow	swissprot:AT134_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AT134_HUMAN
sigcleave	swissprot:AT134_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AT134_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	NAC1_HUMAN	Event=Alternative splicing; Named isoforms=5; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=NaCa1, NCX1.1; IsoId=P32418-1; Sequence=Displayed; Name=3; Synonyms=NaCa3, NCX1.3; IsoId=P32418-2; Sequence=VSP_003397, VSP_003398, VSP_003400; Name=7; Synonyms=NaCa7, NCX1.7; IsoId=P32418-3; Sequence=VSP_003397, VSP_003398, VSP_003399; Name=10; Synonyms=NaCa10, NCX1.10; IsoId=P32418-4; Sequence=VSP_003397, VSP_003398; Name=5; IsoId=P32418-5; Sequence=VSP_003399; 
# AltName	NAC1_HUMAN	Na(+)/Ca(2+)-exchange protein 1
# AltName	NAC1_HUMAN	Solute carrier family 8 member 1
# CCDS	CCDS1806	-. [P32418-1]
# CCDS	CCDS46264	-. [P32418-2]
# CCDS	CCDS46265	-. [P32418-5]
# CCDS	CCDS59430	-. [P32418-4]
# ChiTaRS	SLC8A1	human
# DOMAIN	NAC1_HUMAN	The cytoplasmic Calx-beta domains bind the regulatory Ca(2+). The first Calx-beta domain can bind up to four Ca(2+) ions. The second domain can bind another two Ca(2+) ions that are essential for calcium-regulated ion exchange. {ECO 0000250|UniProtKB P23685}. 
# DrugBank	DB00132	Alpha-Linolenic Acid
# DrugBank	DB00159	Icosapent
# ENZYME REGULATION	Activated by micromolar levels of Ca(2+). {ECO	0000305}. 
# Ensembl	ENST00000332839	ENSP00000332931; ENSG00000183023. [P32418-1]
# Ensembl	ENST00000402441	ENSP00000385188; ENSG00000183023. [P32418-2]
# Ensembl	ENST00000403092	ENSP00000384763; ENSG00000183023. [P32418-1]
# Ensembl	ENST00000405269	ENSP00000385535; ENSG00000183023. [P32418-2]
# Ensembl	ENST00000405901	ENSP00000385678; ENSG00000183023. [P32418-5]
# Ensembl	ENST00000406391	ENSP00000385811; ENSG00000183023. [P32418-2]
# Ensembl	ENST00000406785	ENSP00000383886; ENSG00000183023. [P32418-2]
# Ensembl	ENST00000408028	ENSP00000384908; ENSG00000183023. [P32418-4]
# ExpressionAtlas	P32418	baseline and differential
# FUNCTION	NAC1_HUMAN	Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)- dependent cellular processes (PubMed 1374913, PubMed 11241183, PubMed 1476165). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions. {ECO 0000250|UniProtKB P70414, ECO 0000269|PubMed 11241183, ECO 0000269|PubMed 1374913, ECO 0000269|PubMed 1476165}. 
# GO_component	GO:0005739	mitochondrion; IEA:Ensembl.
# GO_component	GO:0005874	microtubule; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:BHF-UCL.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0014704	intercalated disc; ISS:BHF-UCL.
# GO_component	GO:0030018	Z disc; ISS:BHF-UCL.
# GO_component	GO:0030315	T-tubule; ISS:BHF-UCL.
# GO_component	GO:0042383	sarcolemma; ISS:BHF-UCL.
# GO_component	GO:0043197	dendritic spine; IEA:Ensembl.
# GO_component	GO:0043198	dendritic shaft; IEA:Ensembl.
# GO_function	GO:0005509	calcium ion binding; ISS:UniProtKB.
# GO_function	GO:0008092	cytoskeletal protein binding; IDA:BHF-UCL.
# GO_function	GO:0030506	ankyrin binding; IPI:BHF-UCL.
# GO_function	GO:0044325	ion channel binding; ISS:BHF-UCL.
# GO_function	NAC1_HUMAN	GO 0005432 calcium sodium antiporter activity; IDA BHF-UCL.
# GO_process	GO:0002026	regulation of the force of heart contraction; ISS:BHF-UCL.
# GO_process	GO:0002027	regulation of heart rate; ISS:BHF-UCL.
# GO_process	GO:0002028	regulation of sodium ion transport; IEA:Ensembl.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006883	cellular sodium ion homeostasis; IDA:BHF-UCL.
# GO_process	GO:0006936	muscle contraction; TAS:ProtInc.
# GO_process	GO:0007584	response to nutrient; IEA:Ensembl.
# GO_process	GO:0009749	response to glucose; IEA:Ensembl.
# GO_process	GO:0010649	regulation of cell communication by electrical coupling; TAS:BHF-UCL.
# GO_process	GO:0010763	positive regulation of fibroblast migration; IEA:Ensembl.
# GO_process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; ISS:BHF-UCL.
# GO_process	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling; TAS:BHF-UCL.
# GO_process	GO:0014829	vascular smooth muscle contraction; ISS:BHF-UCL.
# GO_process	GO:0021537	telencephalon development; IEA:Ensembl.
# GO_process	GO:0030501	positive regulation of bone mineralization; IMP:UniProtKB.
# GO_process	GO:0033198	response to ATP; IEA:Ensembl.
# GO_process	GO:0034614	cellular response to reactive oxygen species; IDA:BHF-UCL.
# GO_process	GO:0035725	sodium ion transmembrane transport; IMP:UniProtKB.
# GO_process	GO:0035902	response to immobilization stress; IEA:Ensembl.
# GO_process	GO:0035994	response to muscle stretch; IMP:BHF-UCL.
# GO_process	GO:0042493	response to drug; IEA:Ensembl.
# GO_process	GO:0042542	response to hydrogen peroxide; IEA:Ensembl.
# GO_process	GO:0044557	relaxation of smooth muscle; ISS:BHF-UCL.
# GO_process	GO:0051481	negative regulation of cytosolic calcium ion concentration; ISS:BHF-UCL.
# GO_process	GO:0055013	cardiac muscle cell development; ISS:BHF-UCL.
# GO_process	GO:0055074	calcium ion homeostasis; ISS:BHF-UCL.
# GO_process	GO:0055119	relaxation of cardiac muscle; TAS:BHF-UCL.
# GO_process	GO:0060048	cardiac muscle contraction; TAS:BHF-UCL.
# GO_process	GO:0060401	cytosolic calcium ion transport; TAS:BHF-UCL.
# GO_process	GO:0060402	calcium ion transport into cytosol; ISS:BHF-UCL.
# GO_process	GO:0070509	calcium ion import; IDA:BHF-UCL.
# GO_process	GO:0070588	calcium ion transmembrane transport; IGI:UniProtKB.
# GO_process	GO:0071313	cellular response to caffeine; ISS:BHF-UCL.
# GO_process	GO:0071320	cellular response to cAMP; IEA:Ensembl.
# GO_process	GO:0071436	sodium ion export; IDA:BHF-UCL.
# GO_process	GO:0071456	cellular response to hypoxia; IEA:Ensembl.
# GO_process	GO:0086012	membrane depolarization during cardiac muscle cell action potential; TAS:BHF-UCL.
# GO_process	GO:0086064	cell communication by electrical coupling involved in cardiac conduction; ISS:BHF-UCL.
# GO_process	GO:0097369	sodium ion import; IDA:BHF-UCL.
# GO_process	GO:0098735	positive regulation of the force of heart contraction; IMP:BHF-UCL.
# GO_process	GO:1901660	calcium ion export; IDA:BHF-UCL.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008092	cytoskeletal protein binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0003013	circulatory system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P32418	HS
# HGNC	HGNC:11068	SLC8A1
# InterPro	IPR001623	DnaJ_domain
# InterPro	IPR002987	NaCa_exhngr1
# InterPro	IPR003644	Calx_beta
# InterPro	IPR004836	Na_Ca_Ex
# InterPro	IPR004837	NaCa_Exmemb
# InterPro	IPR032452	Na_Ca_Ex_C-exten
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00536	 Heparan sulfate/heparin binding proteins
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04974	Protein digestion and absorption
# MIM	182305	gene
# Organism	NAC1_HUMAN	Homo sapiens (Human)
# PIR	S32815	S32815
# PRINTS	PR01259	NACAEXCHNGR
# PRINTS	PR01260	NACAEXCHNGR1
# Pfam	PF01699	Na_Ca_ex; 2
# Pfam	PF03160	Calx-beta; 2
# Pfam	PF16494	Na_Ca_ex_C
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-418359	Reduction of cytosolic Ca++ levels
# Reactome	R-HSA-425561	Sodium/Calcium exchangers
# Reactome	R-HSA-5578775	Ion homeostasis
# RecName	NAC1_HUMAN	Sodium/calcium exchanger 1
# RefSeq	NP_001106271	NM_001112800.1. [P32418-5]
# RefSeq	NP_001106272	NM_001112801.1. [P32418-3]
# RefSeq	NP_001106273	NM_001112802.1. [P32418-2]
# RefSeq	NP_001239553	NM_001252624.1. [P32418-4]
# RefSeq	NP_066920	NM_021097.2. [P32418-1]
# RefSeq	XP_005264571	XM_005264514.3. [P32418-2]
# RefSeq	XP_006712144	XM_006712081.2. [P32418-1]
# RefSeq	XP_006712145	XM_006712082.3. [P32418-1]
# RefSeq	XP_006712146	XM_006712083.3. [P32418-1]
# RefSeq	XP_006712147	XM_006712084.3. [P32418-1]
# RefSeq	XP_006712148	XM_006712085.3. [P32418-1]
# RefSeq	XP_011531356	XM_011533054.2. [P32418-1]
# RefSeq	XP_011531357	XM_011533055.2. [P32418-1]
# RefSeq	XP_011531358	XM_011533056.1. [P32418-1]
# RefSeq	XP_016860235	XM_017004746.1. [P32418-1]
# RefSeq	XP_016860237	XM_017004748.1. [P32418-1]
# RefSeq	XP_016860238	XM_017004749.1. [P32418-1]
# RefSeq	XP_016860239	XM_017004750.1. [P32418-1]
# RefSeq	XP_016860240	XM_017004751.1. [P32418-1]
# RefSeq	XP_016860241	XM_017004752.1. [P32418-1]
# RefSeq	XP_016860242	XM_017004753.1. [P32418-1]
# RefSeq	XP_016860243	XM_017004754.1. [P32418-4]
# RefSeq	XP_016860247	XM_017004758.1. [P32418-3]
# SEQUENCE CAUTION	Sequence=AAH98308.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 2 Calx-beta domains. {ECO	0000305}. 
# SMART	SM00237	Calx_beta; 2
# SUBCELLULAR LOCATION	NAC1_HUMAN	Cell membrane {ECO 0000269|PubMed 11241183, ECO 0000269|PubMed 1374913, ECO 0000269|PubMed 1476165}; Multi- pass membrane protein {ECO 0000269|PubMed 23376057}. 
# TCDB	2.A.19.3:the ca(2+)	cation antiporter (caca) family
# TIGRFAMs	TIGR00845	caca
# TISSUE SPECIFICITY	NAC1_HUMAN	Detected primarily in heart and at lower levels in brain (PubMed 1374913). Expressed in cardiac sarcolemma, brain, kidney, liver, pancreas, skeletal muscle, placenta and lung (PubMed 1476165). {ECO 0000269|PubMed 1374913, ECO 0000269|PubMed 1476165}. 
# UCSC	uc002rrx	human. [P32418-1]
# eggNOG	ENOG410XPJP	LUCA
# eggNOG	KOG1306	Eukaryota
BLAST	swissprot:NAC1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NAC1_HUMAN
BioCyc	ZFISH:G66-31047-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31047-MONOMER
COXPRESdb	6546	http://coxpresdb.jp/data/gene/6546.shtml
CleanEx	HS_SLC8A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC8A1
DIP	DIP-48356N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48356N
DOI	10.1007/s00223001098	http://dx.doi.org/10.1007/s00223001098
DOI	10.1016/j.mam.2012.07.003	http://dx.doi.org/10.1016/j.mam.2012.07.003
DOI	10.1016/j.yjmcc.2013.01.010	http://dx.doi.org/10.1016/j.yjmcc.2013.01.010
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.89.10.4769	http://dx.doi.org/10.1073/pnas.89.10.4769
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1677/joe.0.1680517	http://dx.doi.org/10.1677/joe.0.1680517
DrugBank	DB00132	http://www.drugbank.ca/drugs/DB00132
DrugBank	DB00159	http://www.drugbank.ca/drugs/DB00159
EMBL	AB209075	http://www.ebi.ac.uk/ena/data/view/AB209075
EMBL	AC007254	http://www.ebi.ac.uk/ena/data/view/AC007254
EMBL	AC007281	http://www.ebi.ac.uk/ena/data/view/AC007281
EMBL	AC007377	http://www.ebi.ac.uk/ena/data/view/AC007377
EMBL	AF108388	http://www.ebi.ac.uk/ena/data/view/AF108388
EMBL	AF108389	http://www.ebi.ac.uk/ena/data/view/AF108389
EMBL	AF115505	http://www.ebi.ac.uk/ena/data/view/AF115505
EMBL	AF128524	http://www.ebi.ac.uk/ena/data/view/AF128524
EMBL	AK291696	http://www.ebi.ac.uk/ena/data/view/AK291696
EMBL	BC098308	http://www.ebi.ac.uk/ena/data/view/BC098308
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
EMBL	M91368	http://www.ebi.ac.uk/ena/data/view/M91368
Ensembl	ENST00000332839	http://www.ensembl.org/id/ENST00000332839
Ensembl	ENST00000402441	http://www.ensembl.org/id/ENST00000402441
Ensembl	ENST00000403092	http://www.ensembl.org/id/ENST00000403092
Ensembl	ENST00000405269	http://www.ensembl.org/id/ENST00000405269
Ensembl	ENST00000405901	http://www.ensembl.org/id/ENST00000405901
Ensembl	ENST00000406391	http://www.ensembl.org/id/ENST00000406391
Ensembl	ENST00000406785	http://www.ensembl.org/id/ENST00000406785
Ensembl	ENST00000408028	http://www.ensembl.org/id/ENST00000408028
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005874
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0014704	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014704
GO_component	GO:0030018	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030018
GO_component	GO:0030315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030315
GO_component	GO:0042383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042383
GO_component	GO:0043197	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043197
GO_component	GO:0043198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043198
GO_function	GO:0005432	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005432
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0008092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GO_function	GO:0030506	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030506
GO_function	GO:0044325	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044325
GO_process	GO:0002026	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002026
GO_process	GO:0002027	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002027
GO_process	GO:0002028	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002028
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006883	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006883
GO_process	GO:0006936	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006936
GO_process	GO:0007584	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007584
GO_process	GO:0009749	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009749
GO_process	GO:0010649	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010649
GO_process	GO:0010763	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010763
GO_process	GO:0010881	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010881
GO_process	GO:0010882	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010882
GO_process	GO:0014829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014829
GO_process	GO:0021537	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021537
GO_process	GO:0030501	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030501
GO_process	GO:0033198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033198
GO_process	GO:0034614	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034614
GO_process	GO:0035725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035725
GO_process	GO:0035902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035902
GO_process	GO:0035994	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035994
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0042542	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042542
GO_process	GO:0044557	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044557
GO_process	GO:0051481	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051481
GO_process	GO:0055013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055013
GO_process	GO:0055074	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055074
GO_process	GO:0055119	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055119
GO_process	GO:0060048	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060048
GO_process	GO:0060401	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060401
GO_process	GO:0060402	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060402
GO_process	GO:0070509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070509
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:0071313	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071313
GO_process	GO:0071320	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071320
GO_process	GO:0071436	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071436
GO_process	GO:0071456	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071456
GO_process	GO:0086012	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086012
GO_process	GO:0086064	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086064
GO_process	GO:0097369	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097369
GO_process	GO:0098735	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098735
GO_process	GO:1901660	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901660
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0003013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003013
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC8A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC8A1
GeneID	6546	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6546
GeneTree	ENSGT00730000110414	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00730000110414
HGNC	HGNC:11068	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11068
HOGENOM	HOG000266971	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000266971&db=HOGENOM6
HOVERGEN	HBG006441	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006441&db=HOVERGEN
HPA	CAB022694	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB022694
InParanoid	P32418	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32418
IntAct	P32418	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32418*
InterPro	IPR001623	http://www.ebi.ac.uk/interpro/entry/IPR001623
InterPro	IPR002987	http://www.ebi.ac.uk/interpro/entry/IPR002987
InterPro	IPR003644	http://www.ebi.ac.uk/interpro/entry/IPR003644
InterPro	IPR004836	http://www.ebi.ac.uk/interpro/entry/IPR004836
InterPro	IPR004837	http://www.ebi.ac.uk/interpro/entry/IPR004837
InterPro	IPR032452	http://www.ebi.ac.uk/interpro/entry/IPR032452
Jabion	6546	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6546
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00536	http://www.genome.jp/dbget-bin/www_bget?ko00536
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6546	http://www.genome.jp/dbget-bin/www_bget?hsa:6546
KEGG_Orthology	KO:K05849	http://www.genome.jp/dbget-bin/www_bget?KO:K05849
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04974	http://www.genome.jp/kegg-bin/show_pathway?ko04974
MIM	182305	http://www.ncbi.nlm.nih.gov/omim/182305
OMA	DDEECGE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DDEECGE
OrthoDB	EOG091G0EC1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0EC1
PRINTS	PR01259	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01259
PRINTS	PR01260	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01260
PSORT	swissprot:NAC1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NAC1_HUMAN
PSORT-B	swissprot:NAC1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NAC1_HUMAN
PSORT2	swissprot:NAC1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NAC1_HUMAN
Pfam	PF01699	http://pfam.xfam.org/family/PF01699
Pfam	PF03160	http://pfam.xfam.org/family/PF03160
Pfam	PF16494	http://pfam.xfam.org/family/PF16494
PharmGKB	PA314	http://www.pharmgkb.org/do/serve?objId=PA314&objCls=Gene
Phobius	swissprot:NAC1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NAC1_HUMAN
PhylomeDB	P32418	http://phylomedb.org/?seqid=P32418
ProteinModelPortal	P32418	http://www.proteinmodelportal.org/query/uniprot/P32418
PubMed	10908415	http://www.ncbi.nlm.nih.gov/pubmed/10908415
PubMed	11241183	http://www.ncbi.nlm.nih.gov/pubmed/11241183
PubMed	1374913	http://www.ncbi.nlm.nih.gov/pubmed/1374913
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	1476165	http://www.ncbi.nlm.nih.gov/pubmed/1476165
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	23376057	http://www.ncbi.nlm.nih.gov/pubmed/23376057
PubMed	23506867	http://www.ncbi.nlm.nih.gov/pubmed/23506867
PubMed	8048567	http://www.ncbi.nlm.nih.gov/pubmed/8048567
Reactome	R-HSA-418359	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418359
Reactome	R-HSA-425561	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425561
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
RefSeq	NP_001106271	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001106271
RefSeq	NP_001106272	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001106272
RefSeq	NP_001106273	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001106273
RefSeq	NP_001239553	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001239553
RefSeq	NP_066920	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_066920
RefSeq	XP_005264571	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005264571
RefSeq	XP_006712144	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006712144
RefSeq	XP_006712145	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006712145
RefSeq	XP_006712146	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006712146
RefSeq	XP_006712147	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006712147
RefSeq	XP_006712148	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006712148
RefSeq	XP_011531356	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011531356
RefSeq	XP_011531357	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011531357
RefSeq	XP_011531358	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011531358
RefSeq	XP_016860235	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016860235
RefSeq	XP_016860237	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016860237
RefSeq	XP_016860238	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016860238
RefSeq	XP_016860239	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016860239
RefSeq	XP_016860240	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016860240
RefSeq	XP_016860241	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016860241
RefSeq	XP_016860242	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016860242
RefSeq	XP_016860243	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016860243
RefSeq	XP_016860247	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016860247
SMART	SM00237	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00237
SMR	P32418	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32418
STRING	9606.ENSP00000332931	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000332931&targetmode=cogs
TCDB	2.A.19.3	http://www.tcdb.org/search/result.php?tc=2.A.19.3
TIGRFAMs	TIGR00845	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00845
UCSC	uc002rrx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002rrx&org=rat
UniGene	Hs.31961	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.31961
UniGene	Hs.468274	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.468274
UniGene	Hs.744988	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.744988
UniProtKB	NAC1_HUMAN	http://www.uniprot.org/uniprot/NAC1_HUMAN
UniProtKB-AC	P32418	http://www.uniprot.org/uniprot/P32418
charge	swissprot:NAC1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NAC1_HUMAN
eggNOG	ENOG410XPJP	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPJP
eggNOG	KOG1306	http://eggnogapi.embl.de/nog_data/html/tree/KOG1306
epestfind	swissprot:NAC1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NAC1_HUMAN
garnier	swissprot:NAC1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NAC1_HUMAN
helixturnhelix	swissprot:NAC1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NAC1_HUMAN
hmoment	swissprot:NAC1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NAC1_HUMAN
iep	swissprot:NAC1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NAC1_HUMAN
inforesidue	swissprot:NAC1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NAC1_HUMAN
neXtProt	NX_P32418	http://www.nextprot.org/db/entry/NX_P32418
octanol	swissprot:NAC1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NAC1_HUMAN
pepcoil	swissprot:NAC1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NAC1_HUMAN
pepdigest	swissprot:NAC1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NAC1_HUMAN
pepinfo	swissprot:NAC1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NAC1_HUMAN
pepnet	swissprot:NAC1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NAC1_HUMAN
pepstats	swissprot:NAC1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NAC1_HUMAN
pepwheel	swissprot:NAC1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NAC1_HUMAN
pepwindow	swissprot:NAC1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NAC1_HUMAN
sigcleave	swissprot:NAC1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NAC1_HUMAN
## Database	ID	URL or Descriptions
# AltName	CNGA2_HUMAN	Cyclic nucleotide-gated cation channel 2
# AltName	CNGA2_HUMAN	Cyclic nucleotide-gated channel alpha-2
# DOMAIN	CNGA2_HUMAN	The C-terminal coiled-coil domain mediates trimerization of CNGA subunits. {ECO 0000250}. 
# Ensembl	ENST00000329903	ENSP00000328478; ENSG00000183862
# FUNCTION	CNGA2_HUMAN	Odorant signal transduction is probably mediated by a G- protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons. 
# GO_component	GO:0000139	Golgi membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0030660	Golgi-associated vesicle membrane; TAS:Reactome.
# GO_component	GO:0060170	ciliary membrane; TAS:Reactome.
# GO_function	GO:0005222	intracellular cAMP activated cation channel activity; IBA:GO_Central.
# GO_function	GO:0005223	intracellular cGMP activated cation channel activity; IBA:GO_Central.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IBA:GO_Central.
# GO_function	GO:0030552	cAMP binding; IEA:UniProtKB-KW.
# GO_function	GO:0030553	cGMP binding; IBA:GO_Central.
# GO_process	GO:0007608	sensory perception of smell; IEA:UniProtKB-KW.
# GO_process	GO:0042391	regulation of membrane potential; IBA:GO_Central.
# GO_process	GO:0050896	response to stimulus; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# Gene3D	2.60.120.10	-; 1.
# HGNC	HGNC:2149	CNGA2
# InterPro	IPR000595	cNMP-bd_dom
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR014710	RmlC-like_jellyroll
# InterPro	IPR018488	cNMP-bd_CS
# InterPro	IPR018490	cNMP-bd-like
# InterPro	IPR032406	CLZ_dom
# KEGG_Brite	ko04040	Ion channels
# MIM	300338	gene
# Organism	CNGA2_HUMAN	Homo sapiens (Human)
# PIR	I78559	I78559
# PROSITE	PS00888	CNMP_BINDING_1
# PROSITE	PS00889	CNMP_BINDING_2
# PROSITE	PS50042	CNMP_BINDING_3
# Pfam	PF00027	cNMP_binding
# Pfam	PF00520	Ion_trans
# Pfam	PF16526	CLZ
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-5620916	VxPx cargo-targeting to cilium
# RecName	CNGA2_HUMAN	Cyclic nucleotide-gated olfactory channel
# RefSeq	NP_005131	NM_005140.1
# SIMILARITY	Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 cyclic nucleotide-binding domain. {ECO:0000255|PROSITE-ProRule	PRU00060}.
# SMART	SM00100	cNMP
# SUBCELLULAR LOCATION	CNGA2_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Heterotetramer composed of two subunits of CNGA2, one of CNGA4 and one of CNGB1b. The complex forms the cyclic nucleotide- gated (CNG) channel of olfactory sensory neurons (By similarity). {ECO	0000250}. 
# SUPFAM	SSF51206	SSF51206
# UCSC	uc065bqd	human
# eggNOG	ENOG410YWWI	LUCA
# eggNOG	KOG0500	Eukaryota
BLAST	swissprot:CNGA2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CNGA2_HUMAN
COXPRESdb	1260	http://coxpresdb.jp/data/gene/1260.shtml
CleanEx	HS_CNGA2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CNGA2
DOI	10.1016/0028-3908(94)90027-2	http://dx.doi.org/10.1016/0028-3908(94)90027-2
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
EMBL	BC126302	http://www.ebi.ac.uk/ena/data/view/BC126302
EMBL	BC126304	http://www.ebi.ac.uk/ena/data/view/BC126304
EMBL	S76067	http://www.ebi.ac.uk/ena/data/view/S76067
Ensembl	ENST00000329903	http://www.ensembl.org/id/ENST00000329903
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0030660	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030660
GO_component	GO:0060170	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060170
GO_function	GO:0005222	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005222
GO_function	GO:0005223	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005223
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0030552	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030552
GO_function	GO:0030553	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030553
GO_process	GO:0007608	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007608
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0050896	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050896
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
Gene3D	2.60.120.10	http://www.cathdb.info/version/latest/superfamily/2.60.120.10
GeneCards	CNGA2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CNGA2
GeneID	1260	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1260
GeneTree	ENSGT00760000118772	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118772
HGNC	HGNC:2149	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2149
HOGENOM	HOG000007898	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007898&db=HOGENOM6
HOVERGEN	HBG000281	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000281&db=HOVERGEN
HPA	HPA015065	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA015065
InParanoid	Q16280	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q16280
InterPro	IPR000595	http://www.ebi.ac.uk/interpro/entry/IPR000595
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR014710	http://www.ebi.ac.uk/interpro/entry/IPR014710
InterPro	IPR018488	http://www.ebi.ac.uk/interpro/entry/IPR018488
InterPro	IPR018490	http://www.ebi.ac.uk/interpro/entry/IPR018490
InterPro	IPR032406	http://www.ebi.ac.uk/interpro/entry/IPR032406
Jabion	1260	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1260
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:1260	http://www.genome.jp/dbget-bin/www_bget?hsa:1260
KEGG_Orthology	KO:K04949	http://www.genome.jp/dbget-bin/www_bget?KO:K04949
MIM	300338	http://www.ncbi.nlm.nih.gov/omim/300338
OMA	TREYVYC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TREYVYC
OrthoDB	EOG091G03EW	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G03EW
PROSITE	PS00888	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00888
PROSITE	PS00889	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00889
PROSITE	PS50042	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50042
PSORT	swissprot:CNGA2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CNGA2_HUMAN
PSORT-B	swissprot:CNGA2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CNGA2_HUMAN
PSORT2	swissprot:CNGA2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CNGA2_HUMAN
Pfam	PF00027	http://pfam.xfam.org/family/PF00027
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF16526	http://pfam.xfam.org/family/PF16526
PharmGKB	PA26659	http://www.pharmgkb.org/do/serve?objId=PA26659&objCls=Gene
Phobius	swissprot:CNGA2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CNGA2_HUMAN
PhylomeDB	Q16280	http://phylomedb.org/?seqid=Q16280
ProteinModelPortal	Q16280	http://www.proteinmodelportal.org/query/uniprot/Q16280
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	7532814	http://www.ncbi.nlm.nih.gov/pubmed/7532814
Reactome	R-HSA-5620916	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5620916
RefSeq	NP_005131	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005131
SMART	SM00100	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00100
SMR	Q16280	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q16280
STRING	9606.ENSP00000328478	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000328478&targetmode=cogs
SUPFAM	SSF51206	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51206
UCSC	uc065bqd	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc065bqd&org=rat
UniGene	Hs.447360	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.447360
UniProtKB	CNGA2_HUMAN	http://www.uniprot.org/uniprot/CNGA2_HUMAN
UniProtKB-AC	Q16280	http://www.uniprot.org/uniprot/Q16280
charge	swissprot:CNGA2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CNGA2_HUMAN
eggNOG	ENOG410YWWI	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YWWI
eggNOG	KOG0500	http://eggnogapi.embl.de/nog_data/html/tree/KOG0500
epestfind	swissprot:CNGA2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CNGA2_HUMAN
garnier	swissprot:CNGA2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CNGA2_HUMAN
helixturnhelix	swissprot:CNGA2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CNGA2_HUMAN
hmoment	swissprot:CNGA2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CNGA2_HUMAN
iep	swissprot:CNGA2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CNGA2_HUMAN
inforesidue	swissprot:CNGA2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CNGA2_HUMAN
neXtProt	NX_Q16280	http://www.nextprot.org/db/entry/NX_Q16280
octanol	swissprot:CNGA2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CNGA2_HUMAN
pepcoil	swissprot:CNGA2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CNGA2_HUMAN
pepdigest	swissprot:CNGA2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CNGA2_HUMAN
pepinfo	swissprot:CNGA2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CNGA2_HUMAN
pepnet	swissprot:CNGA2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CNGA2_HUMAN
pepstats	swissprot:CNGA2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CNGA2_HUMAN
pepwheel	swissprot:CNGA2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CNGA2_HUMAN
pepwindow	swissprot:CNGA2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CNGA2_HUMAN
sigcleave	swissprot:CNGA2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CNGA2_HUMAN
## Database	ID	URL or Descriptions
# AltName	5HT3C_HUMAN	Serotonin receptor 3C
# BioGrid	128062	81
# DrugBank	DB00898	Ethanol
# DrugBank	DB01049	Ergoloid mesylate
# Ensembl	ENST00000318351	ENSP00000322617; ENSG00000178084
# FUNCTION	5HT3C_HUMAN	This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0004993	G-protein coupled serotonin receptor activity; IDA:CACAO.
# GO_function	GO:0005232	serotonin-activated cation-selective channel activity; IBA:GO_Central.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.370	-; 1.
# Gene3D	2.70.170.10	-; 1.
# Genevisible	Q8WXA8	HS
# HGNC	HGNC:24003	HTR3C
# INTERACTION	5HT3C_HUMAN	P46098 HTR3A; NbExp=5; IntAct=EBI-9008753, EBI-9008743; 
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# InterPro	IPR027361	Acetylcholine_rcpt_TM
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04726	Serotonergic synapse
# MIM	610121	gene
# Organism	5HT3C_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR18945	PTHR18945
# PRINTS	PR00252	NRIONCHANNEL
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-975298	Ligand-gated ion channel transport
# RecName	5HT3C_HUMAN	5-hydroxytryptamine receptor 3C
# RefSeq	NP_570126	NM_130770.2
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3C sub-subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	5HT3C_HUMAN	Cell membrane {ECO 0000269|PubMed 17392525}; Multi-pass membrane protein {ECO 0000269|PubMed 17392525}. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. 
# SUBUNIT	Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex. {ECO:0000269|PubMed	17392525}. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TISSUE SPECIFICITY	Expressed in many tissues including adult brain, colon, intestine, lung, muscle and stomach as well as fetal colon and kidney. {ECO:0000269|PubMed	12801637}. 
# UCSC	uc003fmk	human
# eggNOG	ENOG410XQGR	LUCA
# eggNOG	KOG3645	Eukaryota
BLAST	swissprot:5HT3C_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:5HT3C_HUMAN
BioCyc	ZFISH:ENSG00000178084-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000178084-MONOMER
COXPRESdb	170572	http://coxpresdb.jp/data/gene/170572.shtml
CleanEx	HS_HTR3C	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_HTR3C
DOI	10.1016/S0378-1119(03)00503-1	http://dx.doi.org/10.1016/S0378-1119(03)00503-1
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1124/mol.106.032144	http://dx.doi.org/10.1124/mol.106.032144
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01049	http://www.drugbank.ca/drugs/DB01049
EMBL	AF459285	http://www.ebi.ac.uk/ena/data/view/AF459285
EMBL	BC131799	http://www.ebi.ac.uk/ena/data/view/BC131799
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
Ensembl	ENST00000318351	http://www.ensembl.org/id/ENST00000318351
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0004993	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004993
GO_function	GO:0005232	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005232
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.370	http://www.cathdb.info/version/latest/superfamily/1.20.120.370
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	HTR3C	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=HTR3C
GeneID	170572	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=170572
GeneTree	ENSGT00790000122957	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00790000122957
HGNC	HGNC:24003	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:24003
HOGENOM	HOG000241519	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000241519&db=HOGENOM6
HOVERGEN	HBG106638	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG106638&db=HOVERGEN
HPA	CAB025100	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB025100
InParanoid	Q8WXA8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8WXA8
IntAct	Q8WXA8	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8WXA8*
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
InterPro	IPR027361	http://www.ebi.ac.uk/interpro/entry/IPR027361
Jabion	170572	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=170572
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:170572	http://www.genome.jp/dbget-bin/www_bget?hsa:170572
KEGG_Orthology	KO:K04819	http://www.genome.jp/dbget-bin/www_bget?KO:K04819
KEGG_Pathway	ko04726	http://www.genome.jp/kegg-bin/show_pathway?ko04726
MIM	610121	http://www.ncbi.nlm.nih.gov/omim/610121
OMA	DIFIMES	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DIFIMES
OrthoDB	EOG091G042C	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G042C
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:5HT3C_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:5HT3C_HUMAN
PSORT-B	swissprot:5HT3C_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:5HT3C_HUMAN
PSORT2	swissprot:5HT3C_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:5HT3C_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA134925741	http://www.pharmgkb.org/do/serve?objId=PA134925741&objCls=Gene
Phobius	swissprot:5HT3C_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:5HT3C_HUMAN
PhylomeDB	Q8WXA8	http://phylomedb.org/?seqid=Q8WXA8
ProteinModelPortal	Q8WXA8	http://www.proteinmodelportal.org/query/uniprot/Q8WXA8
PubMed	12801637	http://www.ncbi.nlm.nih.gov/pubmed/12801637
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	17392525	http://www.ncbi.nlm.nih.gov/pubmed/17392525
Reactome	R-HSA-975298	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-975298
RefSeq	NP_570126	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_570126
SMR	Q8WXA8	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8WXA8
STRING	9606.ENSP00000322617	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000322617&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
UCSC	uc003fmk	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003fmk&org=rat
UniGene	Hs.632579	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.632579
UniProtKB	5HT3C_HUMAN	http://www.uniprot.org/uniprot/5HT3C_HUMAN
UniProtKB-AC	Q8WXA8	http://www.uniprot.org/uniprot/Q8WXA8
charge	swissprot:5HT3C_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:5HT3C_HUMAN
eggNOG	ENOG410XQGR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQGR
eggNOG	KOG3645	http://eggnogapi.embl.de/nog_data/html/tree/KOG3645
epestfind	swissprot:5HT3C_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:5HT3C_HUMAN
garnier	swissprot:5HT3C_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:5HT3C_HUMAN
helixturnhelix	swissprot:5HT3C_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:5HT3C_HUMAN
hmoment	swissprot:5HT3C_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:5HT3C_HUMAN
iep	swissprot:5HT3C_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:5HT3C_HUMAN
inforesidue	swissprot:5HT3C_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:5HT3C_HUMAN
neXtProt	NX_Q8WXA8	http://www.nextprot.org/db/entry/NX_Q8WXA8
octanol	swissprot:5HT3C_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:5HT3C_HUMAN
pepcoil	swissprot:5HT3C_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:5HT3C_HUMAN
pepdigest	swissprot:5HT3C_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:5HT3C_HUMAN
pepinfo	swissprot:5HT3C_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:5HT3C_HUMAN
pepnet	swissprot:5HT3C_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:5HT3C_HUMAN
pepstats	swissprot:5HT3C_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:5HT3C_HUMAN
pepwheel	swissprot:5HT3C_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:5HT3C_HUMAN
pepwindow	swissprot:5HT3C_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:5HT3C_HUMAN
sigcleave	swissprot:5HT3C_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:5HT3C_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TRPV6_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H1D0-1; Sequence=Displayed; Name=2; IsoId=Q9H1D0-2; Sequence=VSP_013439; 
# AltName	CaT-like {ECO:0000303|PubMed	11278579}
# AltName	Calcium transport protein 1 {ECO:0000303|PubMed	11097838}
# AltName	TRPV6_HUMAN	Epithelial calcium channel 2
# BioGrid	120683	14
# CCDS	CCDS5874	-. [Q9H1D0-1]
# Ensembl	ENST00000359396	ENSP00000352358; ENSG00000165125
# ExpressionAtlas	Q9H1D0	baseline and differential
# FUNCTION	TRPV6_HUMAN	Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed 11097838, PubMed 11278579, PubMed 11248124 PubMed 15184369, PubMed 23612980). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed 15184369). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)- calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. {ECO 0000250|UniProtKB Q91WD2, ECO 0000269|PubMed 11097838, ECO 0000269|PubMed 11248124, ECO 0000269|PubMed 11278579, ECO 0000269|PubMed 15184369, ECO 0000269|PubMed 23612980}. 
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005262	calcium channel activity; IDA:UniProtKB.
# GO_function	GO:0005516	calmodulin binding; IDA:UniProtKB.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0006816	calcium ion transport; IDA:UniProtKB.
# GO_process	GO:0017158	regulation of calcium ion-dependent exocytosis; NAS:UniProtKB.
# GO_process	GO:0051592	response to calcium ion; ISS:UniProtKB.
# GO_process	GO:0055074	calcium ion homeostasis; ISS:UniProtKB.
# GO_process	GO:0070588	calcium ion transmembrane transport; IDA:UniProtKB.
# GO_process	GO:1990035	calcium ion import into cell; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.25.40.20	-; 2.
# Genevisible	Q9H1D0	HS
# HGNC	HGNC:14006	TRPV6
# INTERACTION	TRPV6_HUMAN	P18031 PTPN1; NbExp=6; IntAct=EBI-7198335, EBI-968788; 
# IntAct	Q9H1D0	2
# InterPro	IPR002110	Ankyrin_rpt
# InterPro	IPR004729	TRP_channel
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR008344	TRPV5/TRPV6
# InterPro	IPR008345	TRPV6_channel
# InterPro	IPR020683	Ankyrin_rpt-contain_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04970	Salivary secretion
# KEGG_Pathway	ko04978	Mineral absorption
# MIM	606680	gene
# Organism	TRPV6_HUMAN	Homo sapiens (Human)
# PIR	JC7531	JC7531
# PRINTS	PR01415	ANKYRIN
# PRINTS	PR01765	ECACCHANNEL
# PRINTS	PR01766	ECACCHANNEL1
# PROSITE	PS50088	ANK_REPEAT; 2
# PROSITE	PS50297	ANK_REP_REGION
# PTM	TRPV6_HUMAN	Glycosylated. {ECO 0000250|UniProtKB Q91WD2, ECO 0000269|PubMed 23612980}. 
# PTM	TRPV6_HUMAN	Phosphorylation at Tyr-201 by SRC leads to an increased calcium influx through the channel. Probably dephosphorylated at this site by PTPN1 (By similarity). Phosphorylation by PRKCA at the calmodulin binding site delays channel inactivation (PubMed 11248124). {ECO 0000250|UniProtKB Q9R186, ECO 0000269|PubMed 11248124}. 
# Pfam	PF00023	Ank
# Pfam	PF00520	Ion_trans
# Pfam	PF12796	Ank_2
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-3295583	TRP channels
# RecName	TRPV6_HUMAN	Transient receptor potential cation channel subfamily V member 6
# RefSeq	NP_061116	NM_018646.5. [Q9H1D0-1]
# SEQUENCE CAUTION	TRPV6_HUMAN	Sequence=AAK50426.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ACG threonine codon.; Evidence={ECO 0000305|PubMed 23612980}; Sequence=AAL40230.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ACG threonine codon.; Evidence={ECO 0000305|PubMed 23612980}; Sequence=AAM00356.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ACG threonine codon.; Evidence={ECO 0000305|PubMed 23612980}; Sequence=AAO38052.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ACG threonine codon.; Evidence={ECO 0000305|PubMed 23612980}; Sequence=BAF84396.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ACG threonine codon.; Evidence={ECO 0000305|PubMed 23612980}; Sequence=CAC20416.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ACG threonine codon.; Evidence={ECO 0000305|PubMed 23612980}; Sequence=CAC20417.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ACG threonine codon.; Evidence={ECO 0000305|PubMed 23612980}; Sequence=CAD32311.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ACG threonine codon.; Evidence={ECO 0000305|PubMed 23612980}; 
# SIMILARITY	Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV6 sub-subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 6 ANK repeats. {ECO:0000255|PROSITE- ProRule	PRU00023}. 
# SMART	SM00248	ANK; 5
# SUBCELLULAR LOCATION	TRPV6_HUMAN	Cell membrane {ECO 0000269|PubMed 11097838, ECO 0000269|PubMed 11248124, ECO 0000269|PubMed 11278579, ECO 0000269|PubMed 15184369, ECO 0000269|PubMed 23612980}; Multi- pass membrane protein {ECO 0000250|UniProtKB Q91WD2}. 
# SUBUNIT	TRPV6_HUMAN	Homotetramer and probably heterotetramer with TRPV5. Interacts with TRPV5. Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with BSPRY (By similarity). Interacts with TCAF1 and TCAF2 isoform 2 (PubMed 25559186). Interacts with calmodulin (PubMed 11248124). {ECO 0000250|UniProtKB Q91WD2, ECO 0000269|PubMed 11248124, ECO 0000269|PubMed 25559186}. 
# SUPFAM	SSF48403	SSF48403
# TCDB	1.A.4.2.11	the transient receptor potential ca(2+) channel (trp-cc) family
# TIGRFAMs	TIGR00870	trp
# TISSUE SPECIFICITY	TRPV6_HUMAN	Expressed at high levels in the gastrointestinal tract, including esophagus, stomach, duodenum, jejunum, ileum and colon, and in pancreas, placenta, prostate and salivary gland. Expressed at moderate levels in liver, kidney and testis. Expressed in trophoblasts of placenta villus trees (at protein level)(PubMed 23612980). Expressed in locally advanced prostate cancer, metastatic and androgen-insensitive prostatic lesions but not detected in healthy prostate tissue and benign prostatic hyperplasia. {ECO 0000269|PubMed 11097838, ECO 0000269|PubMed 11278579, ECO 0000269|PubMed 23612980}. 
# UCSC	uc003wbx	human. [Q9H1D0-1]
# WEB RESOURCE	TRPV6_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/TRPV6ID44425ch7q34.html";
# WEB RESOURCE	TRPV6_HUMAN	Name=SeattleSNPs; URL="http //pga.gs.washington.edu/data/trpv5/"; 
# WEB RESOURCE	TRPV6_HUMAN	Name=Wikipedia; Note=TRPV6 entry; URL="https //en.wikipedia.org/wiki/TRPV6"; 
# eggNOG	ENOG4110DG4	LUCA
# eggNOG	KOG3676	Eukaryota
BLAST	swissprot:TRPV6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TRPV6_HUMAN
BioCyc	ZFISH:ENSG00000165125-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000165125-MONOMER
COXPRESdb	55503	http://coxpresdb.jp/data/gene/55503.shtml
CleanEx	HS_TRPV6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TRPV6
DOI	10.1006/bbrc.2000.3716	http://dx.doi.org/10.1006/bbrc.2000.3716
DOI	10.1006/geno.2001.6606	http://dx.doi.org/10.1006/geno.2001.6606
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.051511398	http://dx.doi.org/10.1073/pnas.051511398
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/jbc.M009895200	http://dx.doi.org/10.1074/jbc.M009895200
DOI	10.1074/jbc.M113.469726	http://dx.doi.org/10.1074/jbc.M113.469726
DOI	10.1074/jbc.M404679200	http://dx.doi.org/10.1074/jbc.M404679200
DOI	10.1083/jcb.201402076	http://dx.doi.org/10.1083/jcb.201402076
DOI	10.1126/science.1083423	http://dx.doi.org/10.1126/science.1083423
DOI	10.1186/1472-6793-1-11	http://dx.doi.org/10.1186/1472-6793-1-11
EMBL	AF304463	http://www.ebi.ac.uk/ena/data/view/AF304463
EMBL	AF365927	http://www.ebi.ac.uk/ena/data/view/AF365927
EMBL	AF365928	http://www.ebi.ac.uk/ena/data/view/AF365928
EMBL	AH010730	http://www.ebi.ac.uk/ena/data/view/AH010730
EMBL	AJ243500	http://www.ebi.ac.uk/ena/data/view/AJ243500
EMBL	AJ243501	http://www.ebi.ac.uk/ena/data/view/AJ243501
EMBL	AJ487964	http://www.ebi.ac.uk/ena/data/view/AJ487964
EMBL	AK291707	http://www.ebi.ac.uk/ena/data/view/AK291707
EMBL	AY225461	http://www.ebi.ac.uk/ena/data/view/AY225461
EMBL	CH236959	http://www.ebi.ac.uk/ena/data/view/CH236959
Ensembl	ENST00000359396	http://www.ensembl.org/id/ENST00000359396
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0005516	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005516
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0017158	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017158
GO_process	GO:0051592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051592
GO_process	GO:0055074	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055074
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:1990035	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990035
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.25.40.20	http://www.cathdb.info/version/latest/superfamily/1.25.40.20
GeneCards	TRPV6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TRPV6
GeneID	55503	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55503
H-InvDB	HIX0007162	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0007162
HGNC	HGNC:14006	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14006
HOVERGEN	HBG061442	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG061442&db=HOVERGEN
HPA	HPA062644	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA062644
HPA	HPA062864	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA062864
InParanoid	Q9H1D0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9H1D0
IntAct	Q9H1D0	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9H1D0*
InterPro	IPR002110	http://www.ebi.ac.uk/interpro/entry/IPR002110
InterPro	IPR004729	http://www.ebi.ac.uk/interpro/entry/IPR004729
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR008344	http://www.ebi.ac.uk/interpro/entry/IPR008344
InterPro	IPR008345	http://www.ebi.ac.uk/interpro/entry/IPR008345
InterPro	IPR020683	http://www.ebi.ac.uk/interpro/entry/IPR020683
Jabion	55503	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55503
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:55503	http://www.genome.jp/dbget-bin/www_bget?hsa:55503
KEGG_Orthology	KO:K04975	http://www.genome.jp/dbget-bin/www_bget?KO:K04975
KEGG_Pathway	ko04970	http://www.genome.jp/kegg-bin/show_pathway?ko04970
KEGG_Pathway	ko04978	http://www.genome.jp/kegg-bin/show_pathway?ko04978
MIM	606680	http://www.ncbi.nlm.nih.gov/omim/606680
MINT	MINT-1472896	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1472896
OrthoDB	EOG091G0314	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0314
PRINTS	PR01415	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01415
PRINTS	PR01765	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01765
PRINTS	PR01766	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01766
PROSITE	PS50088	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50088
PROSITE	PS50297	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50297
PSORT	swissprot:TRPV6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TRPV6_HUMAN
PSORT-B	swissprot:TRPV6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TRPV6_HUMAN
PSORT2	swissprot:TRPV6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TRPV6_HUMAN
Pfam	PF00023	http://pfam.xfam.org/family/PF00023
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF12796	http://pfam.xfam.org/family/PF12796
PharmGKB	PA37832	http://www.pharmgkb.org/do/serve?objId=PA37832&objCls=Gene
Phobius	swissprot:TRPV6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TRPV6_HUMAN
ProteinModelPortal	Q9H1D0	http://www.proteinmodelportal.org/query/uniprot/Q9H1D0
PubMed	11097838	http://www.ncbi.nlm.nih.gov/pubmed/11097838
PubMed	11248124	http://www.ncbi.nlm.nih.gov/pubmed/11248124
PubMed	11278579	http://www.ncbi.nlm.nih.gov/pubmed/11278579
PubMed	11545681	http://www.ncbi.nlm.nih.gov/pubmed/11545681
PubMed	11549322	http://www.ncbi.nlm.nih.gov/pubmed/11549322
PubMed	12690205	http://www.ncbi.nlm.nih.gov/pubmed/12690205
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15184369	http://www.ncbi.nlm.nih.gov/pubmed/15184369
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	23612980	http://www.ncbi.nlm.nih.gov/pubmed/23612980
PubMed	25559186	http://www.ncbi.nlm.nih.gov/pubmed/25559186
Reactome	R-HSA-3295583	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3295583
RefSeq	NP_061116	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061116
SMART	SM00248	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00248
SMR	Q9H1D0	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9H1D0
STRING	9606.ENSP00000352358	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000352358&targetmode=cogs
SUPFAM	SSF48403	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48403
TCDB	1.A.4.2.11	http://www.tcdb.org/search/result.php?tc=1.A.4.2.11
TIGRFAMs	TIGR00870	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00870
UCSC	uc003wbx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003wbx&org=rat
UniGene	Hs.302740	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.302740
UniProtKB	TRPV6_HUMAN	http://www.uniprot.org/uniprot/TRPV6_HUMAN
UniProtKB-AC	Q9H1D0	http://www.uniprot.org/uniprot/Q9H1D0
charge	swissprot:TRPV6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TRPV6_HUMAN
eggNOG	ENOG4110DG4	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110DG4
eggNOG	KOG3676	http://eggnogapi.embl.de/nog_data/html/tree/KOG3676
epestfind	swissprot:TRPV6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TRPV6_HUMAN
garnier	swissprot:TRPV6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TRPV6_HUMAN
helixturnhelix	swissprot:TRPV6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRPV6_HUMAN
hmoment	swissprot:TRPV6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TRPV6_HUMAN
iep	swissprot:TRPV6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TRPV6_HUMAN
inforesidue	swissprot:TRPV6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TRPV6_HUMAN
neXtProt	NX_Q9H1D0	http://www.nextprot.org/db/entry/NX_Q9H1D0
octanol	swissprot:TRPV6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TRPV6_HUMAN
pepcoil	swissprot:TRPV6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TRPV6_HUMAN
pepdigest	swissprot:TRPV6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TRPV6_HUMAN
pepinfo	swissprot:TRPV6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TRPV6_HUMAN
pepnet	swissprot:TRPV6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TRPV6_HUMAN
pepstats	swissprot:TRPV6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TRPV6_HUMAN
pepwheel	swissprot:TRPV6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TRPV6_HUMAN
pepwindow	swissprot:TRPV6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TRPV6_HUMAN
sigcleave	swissprot:TRPV6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TRPV6_HUMAN
## Database	ID	URL or Descriptions
# AltName	CCG4_HUMAN	Neuronal voltage-gated calcium channel gamma-4 subunit
# AltName	CCG4_HUMAN	Transmembrane AMPAR regulatory protein gamma-4
# BioGrid	117994	17
# Ensembl	ENST00000262138	ENSP00000262138; ENSG00000075461
# ExpressionAtlas	Q9UBN1	baseline and differential
# FUNCTION	CCG4_HUMAN	Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. {ECO 0000269|PubMed 21172611}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0005891	voltage-gated calcium channel complex; IEA:InterPro.
# GO_component	GO:0030666	endocytic vesicle membrane; TAS:Reactome.
# GO_component	GO:0032281	AMPA glutamate receptor complex; ISS:UniProtKB.
# GO_function	GO:0005245	voltage-gated calcium channel activity; TAS:ProtInc.
# GO_function	GO:0005262	calcium channel activity; TAS:Reactome.
# GO_function	GO:0016247	channel regulator activity; IBA:GO_Central.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0019226	transmission of nerve impulse; IBA:GO_Central.
# GO_process	GO:0051899	membrane depolarization; TAS:Reactome.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# Genevisible	Q9UBN1	HS
# HGNC	HGNC:1408	CACNG4
# InterPro	IPR004031	PMP22/EMP/MP20/Claudin
# InterPro	IPR005423	VDCC_g4su
# InterPro	IPR008368	VDCC_gsu
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04010	MAPK signaling pathway
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05410	Hypertrophic cardiomyopathy (HCM)
# KEGG_Pathway	ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
# KEGG_Pathway	ko05414	Dilated cardiomyopathy
# MIM	606404	gene
# Organism	CCG4_HUMAN	Homo sapiens (Human)
# PRINTS	PR01603	VDCCGAMMA4
# PRINTS	PR01792	VDCCGAMMA
# Pfam	PF00822	PMP22_Claudin
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-112308	Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
# Reactome	R-HSA-399719	Trafficking of AMPA receptors
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# Reactome	R-HSA-5576893	Phase 2 - plateau phase
# Reactome	R-HSA-5576894	Phase 1 - inactivation of fast Na+ channels
# Reactome	R-HSA-5682910	LGI-ADAM interactions
# RecName	CCG4_HUMAN	Voltage-dependent calcium channel gamma-4 subunit
# RefSeq	NP_055220	NM_014405.3
# SIMILARITY	Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	CCG4_HUMAN	Cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUBUNIT	The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG5, CACNG7 and CACNG8 (By similarity). {ECO	0000250}. 
# TCDB	8.A.16.2	the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family
# UCSC	uc002jft	human
# eggNOG	ENOG410IJYN	Eukaryota
# eggNOG	ENOG4111W1R	LUCA
BLAST	swissprot:CCG4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CCG4_HUMAN
BioCyc	ZFISH:ENSG00000075461-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000075461-MONOMER
COXPRESdb	27092	http://coxpresdb.jp/data/gene/27092.shtml
CleanEx	HS_CACNG4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CACNG4
DOI	10.1016/j.neuron.2010.11.026	http://dx.doi.org/10.1016/j.neuron.2010.11.026
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1101/gr.9.12.1204	http://dx.doi.org/10.1101/gr.9.12.1204
EMBL	AF142622	http://www.ebi.ac.uk/ena/data/view/AF142622
EMBL	AF142623	http://www.ebi.ac.uk/ena/data/view/AF142623
EMBL	AF142624	http://www.ebi.ac.uk/ena/data/view/AF142624
EMBL	AF142625	http://www.ebi.ac.uk/ena/data/view/AF142625
EMBL	AF162692	http://www.ebi.ac.uk/ena/data/view/AF162692
EMBL	AK315149	http://www.ebi.ac.uk/ena/data/view/AK315149
EMBL	BC034532	http://www.ebi.ac.uk/ena/data/view/BC034532
EMBL	CH471099	http://www.ebi.ac.uk/ena/data/view/CH471099
Ensembl	ENST00000262138	http://www.ensembl.org/id/ENST00000262138
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005891
GO_component	GO:0030666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030666
GO_component	GO:0032281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032281
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0016247	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016247
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0019226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019226
GO_process	GO:0051899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051899
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:2000311	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000311
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	CACNG4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CACNG4
GeneID	27092	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27092
GeneTree	ENSGT00550000074547	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074547
HGNC	HGNC:1408	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1408
HOGENOM	HOG000233440	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233440&db=HOGENOM6
HOVERGEN	HBG003682	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003682&db=HOVERGEN
HPA	HPA060718	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA060718
HPA	HPA065370	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA065370
InParanoid	Q9UBN1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UBN1
InterPro	IPR004031	http://www.ebi.ac.uk/interpro/entry/IPR004031
InterPro	IPR005423	http://www.ebi.ac.uk/interpro/entry/IPR005423
InterPro	IPR008368	http://www.ebi.ac.uk/interpro/entry/IPR008368
Jabion	27092	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=27092
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:27092	http://www.genome.jp/dbget-bin/www_bget?hsa:27092
KEGG_Orthology	KO:K04869	http://www.genome.jp/dbget-bin/www_bget?KO:K04869
KEGG_Pathway	ko04010	http://www.genome.jp/kegg-bin/show_pathway?ko04010
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05410	http://www.genome.jp/kegg-bin/show_pathway?ko05410
KEGG_Pathway	ko05412	http://www.genome.jp/kegg-bin/show_pathway?ko05412
KEGG_Pathway	ko05414	http://www.genome.jp/kegg-bin/show_pathway?ko05414
MIM	606404	http://www.ncbi.nlm.nih.gov/omim/606404
OMA	ICNGTNL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ICNGTNL
OrthoDB	EOG091G0D2Z	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0D2Z
PRINTS	PR01603	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01603
PRINTS	PR01792	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01792
PSORT	swissprot:CCG4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CCG4_HUMAN
PSORT-B	swissprot:CCG4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CCG4_HUMAN
PSORT2	swissprot:CCG4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CCG4_HUMAN
Pfam	PF00822	http://pfam.xfam.org/family/PF00822
PharmGKB	PA26018	http://www.pharmgkb.org/do/serve?objId=PA26018&objCls=Gene
Phobius	swissprot:CCG4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CCG4_HUMAN
PhylomeDB	Q9UBN1	http://phylomedb.org/?seqid=Q9UBN1
ProteinModelPortal	Q9UBN1	http://www.proteinmodelportal.org/query/uniprot/Q9UBN1
PubMed	10613843	http://www.ncbi.nlm.nih.gov/pubmed/10613843
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21172611	http://www.ncbi.nlm.nih.gov/pubmed/21172611
Reactome	R-HSA-112308	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112308
Reactome	R-HSA-399719	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-399719
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
Reactome	R-HSA-5576893	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576893
Reactome	R-HSA-5576894	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576894
Reactome	R-HSA-5682910	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5682910
RefSeq	NP_055220	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055220
STRING	9606.ENSP00000262138	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000262138&targetmode=cogs
TCDB	8.A.16.2	http://www.tcdb.org/search/result.php?tc=8.A.16.2
UCSC	uc002jft	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002jft&org=rat
UniGene	Hs.514423	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.514423
UniProtKB	CCG4_HUMAN	http://www.uniprot.org/uniprot/CCG4_HUMAN
UniProtKB-AC	Q9UBN1	http://www.uniprot.org/uniprot/Q9UBN1
charge	swissprot:CCG4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CCG4_HUMAN
eggNOG	ENOG410IJYN	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IJYN
eggNOG	ENOG4111W1R	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111W1R
epestfind	swissprot:CCG4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CCG4_HUMAN
garnier	swissprot:CCG4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CCG4_HUMAN
helixturnhelix	swissprot:CCG4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CCG4_HUMAN
hmoment	swissprot:CCG4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CCG4_HUMAN
iep	swissprot:CCG4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CCG4_HUMAN
inforesidue	swissprot:CCG4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CCG4_HUMAN
neXtProt	NX_Q9UBN1	http://www.nextprot.org/db/entry/NX_Q9UBN1
octanol	swissprot:CCG4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CCG4_HUMAN
pepcoil	swissprot:CCG4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CCG4_HUMAN
pepdigest	swissprot:CCG4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CCG4_HUMAN
pepinfo	swissprot:CCG4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CCG4_HUMAN
pepnet	swissprot:CCG4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CCG4_HUMAN
pepstats	swissprot:CCG4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CCG4_HUMAN
pepwheel	swissprot:CCG4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CCG4_HUMAN
pepwindow	swissprot:CCG4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CCG4_HUMAN
sigcleave	swissprot:CCG4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CCG4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CB083_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q53S99-1; Sequence=Displayed; Name=2; IsoId=Q53S99-2; Sequence=VSP_045403; Note=No experimental confirmation available.; 
# CAUTION	Although related to reduced folate carrier family, it lacks transmembrane domains, suggesting that it has probably no transporter function. {ECO	0000305}. 
# CCDS	CCDS33388	-. [Q53S99-1]
# CCDS	CCDS54434	-. [Q53S99-2]
# Ensembl	ENST00000264387	ENSP00000264387; ENSG00000042304. [Q53S99-1]
# Ensembl	ENST00000409066	ENSP00000387149; ENSG00000042304. [Q53S99-2]
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0015403	thiamine uptake transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0071934	thiamine transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q53S99	HS
# HGNC	HGNC:25344	C2orf83
# InterPro	IPR002666	Folate_carrier
# Organism	CB083_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10686	PTHR10686
# Pfam	PF01770	Folate_carrier
# Proteomes	UP000005640	Chromosome 2
# RecName	CB083_HUMAN	Folate transporter-like protein C2orf83
# RefSeq	NP_001155955	NM_001162483.1. [Q53S99-2]
# RefSeq	NP_064546	NM_020161.3. [Q53S99-1]
# SEQUENCE CAUTION	Sequence=CAB95774.1; Type=Erroneous termination; Positions=141; Note=Translated as Trp.; Evidence={ECO:0000305}; Sequence=CAH18470.1; Type=Erroneous termination; Positions=141; Note=Translated as Trp.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family. {ECO	0000305}. 
# UCSC	uc002vph	human. [Q53S99-1]
# eggNOG	ENOG410XT34	LUCA
# eggNOG	KOG3810	Eukaryota
BLAST	swissprot:CB083_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CB083_HUMAN
COXPRESdb	56918	http://coxpresdb.jp/data/gene/56918.shtml
CleanEx	HS_C2orf83	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_C2orf83
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AC064853	http://www.ebi.ac.uk/ena/data/view/AC064853
EMBL	AK055355	http://www.ebi.ac.uk/ena/data/view/AK055355
EMBL	AL359944	http://www.ebi.ac.uk/ena/data/view/AL359944
EMBL	BC131618	http://www.ebi.ac.uk/ena/data/view/BC131618
EMBL	CH471063	http://www.ebi.ac.uk/ena/data/view/CH471063
EMBL	CH471063	http://www.ebi.ac.uk/ena/data/view/CH471063
EMBL	CR749679	http://www.ebi.ac.uk/ena/data/view/CR749679
Ensembl	ENST00000264387	http://www.ensembl.org/id/ENST00000264387
Ensembl	ENST00000409066	http://www.ensembl.org/id/ENST00000409066
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0015403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015403
GO_process	GO:0071934	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071934
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	C2orf83	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=C2orf83
GeneID	56918	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56918
GeneTree	ENSGT00390000007980	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000007980
H-InvDB	HIX0200277	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0200277
HGNC	HGNC:25344	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:25344
HOGENOM	HOG000111339	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000111339&db=HOGENOM6
HPA	HPA030319	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA030319
InParanoid	Q53S99	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q53S99
InterPro	IPR002666	http://www.ebi.ac.uk/interpro/entry/IPR002666
Jabion	56918	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=56918
KEGG_Gene	hsa:56918	http://www.genome.jp/dbget-bin/www_bget?hsa:56918
MINT	MINT-4722244	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4722244
OMA	GHGLCHP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GHGLCHP
OrthoDB	EOG091G0Q8D	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0Q8D
PANTHER	PTHR10686	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10686
PSORT	swissprot:CB083_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CB083_HUMAN
PSORT-B	swissprot:CB083_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CB083_HUMAN
PSORT2	swissprot:CB083_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CB083_HUMAN
Pfam	PF01770	http://pfam.xfam.org/family/PF01770
PharmGKB	PA164717149	http://www.pharmgkb.org/do/serve?objId=PA164717149&objCls=Gene
Phobius	swissprot:CB083_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CB083_HUMAN
PhylomeDB	Q53S99	http://phylomedb.org/?seqid=Q53S99
ProteinModelPortal	Q53S99	http://www.proteinmodelportal.org/query/uniprot/Q53S99
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
RefSeq	NP_001155955	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001155955
RefSeq	NP_064546	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_064546
STRING	9606.ENSP00000264387	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000264387&targetmode=cogs
UCSC	uc002vph	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002vph&org=rat
UniGene	Hs.283092	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.283092
UniProtKB	CB083_HUMAN	http://www.uniprot.org/uniprot/CB083_HUMAN
UniProtKB-AC	Q53S99	http://www.uniprot.org/uniprot/Q53S99
charge	swissprot:CB083_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CB083_HUMAN
eggNOG	ENOG410XT34	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XT34
eggNOG	KOG3810	http://eggnogapi.embl.de/nog_data/html/tree/KOG3810
epestfind	swissprot:CB083_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CB083_HUMAN
garnier	swissprot:CB083_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CB083_HUMAN
helixturnhelix	swissprot:CB083_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CB083_HUMAN
hmoment	swissprot:CB083_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CB083_HUMAN
iep	swissprot:CB083_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CB083_HUMAN
inforesidue	swissprot:CB083_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CB083_HUMAN
neXtProt	NX_Q53S99	http://www.nextprot.org/db/entry/NX_Q53S99
octanol	swissprot:CB083_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CB083_HUMAN
pepcoil	swissprot:CB083_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CB083_HUMAN
pepdigest	swissprot:CB083_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CB083_HUMAN
pepinfo	swissprot:CB083_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CB083_HUMAN
pepnet	swissprot:CB083_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CB083_HUMAN
pepstats	swissprot:CB083_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CB083_HUMAN
pepwheel	swissprot:CB083_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CB083_HUMAN
pepwindow	swissprot:CB083_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CB083_HUMAN
sigcleave	swissprot:CB083_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CB083_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	RBP17_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H2T7-1; Sequence=Displayed; Name=2; IsoId=Q9H2T7-2; Sequence=VSP_056669, VSP_056670; 
# BioGrid	122341	8
# CCDS	CCDS34287	-. [Q9H2T7-1]
# ChiTaRS	RANBP17	human
# Ensembl	ENST00000389118	ENSP00000373770; ENSG00000204764. [Q9H2T7-2]
# Ensembl	ENST00000519256	ENSP00000429298; ENSG00000204764. [Q9H2T7-2]
# Ensembl	ENST00000519949	ENSP00000430444; ENSG00000204764. [Q9H2T7-2]
# Ensembl	ENST00000522533	ENSP00000430599; ENSG00000204764. [Q9H2T7-2]
# Ensembl	ENST00000523189	ENSP00000427975; ENSG00000204764. [Q9H2T7-1]
# ExpressionAtlas	Q9H2T7	baseline and differential
# FUNCTION	RBP17_HUMAN	May function as a nuclear transport receptor. {ECO 0000250}. 
# GO_component	GO:0005643	nuclear pore; NAS:UniProtKB.
# GO_component	GO:0005737	cytoplasm; IBA:GO_Central.
# GO_function	GO:0005049	nuclear export signal receptor activity; IBA:GO_Central.
# GO_function	GO:0005525	GTP binding; NAS:UniProtKB.
# GO_function	GO:0008536	Ran GTPase binding; IBA:GO_Central.
# GO_process	GO:0006606	protein import into nucleus; NAS:UniProtKB.
# GO_process	GO:0006611	protein export from nucleus; IBA:GO_Central.
# GO_process	GO:0051028	mRNA transport; IEA:UniProtKB-KW.
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# Gene3D	1.25.10.10	-; 1.
# Genevisible	Q9H2T7	HS
# HGNC	HGNC:14428	RANBP17
# InterPro	IPR001494	Importin-beta_N
# InterPro	IPR011989	ARM-like
# InterPro	IPR016024	ARM-type_fold
# MIM	606141	gene
# Organism	RBP17_HUMAN	Homo sapiens (Human)
# Pfam	PF03810	IBN_N
# Proteomes	UP000005640	Chromosome 5
# RecName	RBP17_HUMAN	Ran-binding protein 17
# RefSeq	NP_075048	NM_022897.4. [Q9H2T7-1]
# SEQUENCE CAUTION	Sequence=BAB55427.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the exportin family. {ECO	0000305}. 
# SMART	SM00913	IBN_N
# SUBCELLULAR LOCATION	RBP17_HUMAN	Cytoplasm {ECO 0000250}. Nucleus {ECO 0000250}. Nucleus, nuclear pore complex {ECO 0000250}. 
# SUBUNIT	Binds to nucleoporins and the GTP-bound form of Ran. {ECO	0000250}. 
# SUPFAM	SSF48371	SSF48371; 3
# TCDB	1.I.1.1	the nuclear pore complex (npc) family
# TISSUE SPECIFICITY	Highly expressed in testis, moderately in pancreas and weakly in other tissues studied. {ECO:0000269|PubMed	11071879}. 
# UCSC	uc003mba	human. [Q9H2T7-1]
# eggNOG	ENOG410XRPR	LUCA
# eggNOG	KOG1410	Eukaryota
BLAST	swissprot:RBP17_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:RBP17_HUMAN
BioCyc	ZFISH:G66-33598-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33598-MONOMER
COXPRESdb	64901	http://coxpresdb.jp/data/gene/64901.shtml
CleanEx	HS_RANBP17	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_RANBP17
DOI	10.1006/bbrc.2000.3788	http://dx.doi.org/10.1006/bbrc.2000.3788
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M006242200	http://dx.doi.org/10.1074/jbc.M006242200
EMBL	AC008514	http://www.ebi.ac.uk/ena/data/view/AC008514
EMBL	AC010306	http://www.ebi.ac.uk/ena/data/view/AC010306
EMBL	AC016574	http://www.ebi.ac.uk/ena/data/view/AC016574
EMBL	AC018753	http://www.ebi.ac.uk/ena/data/view/AC018753
EMBL	AC021077	http://www.ebi.ac.uk/ena/data/view/AC021077
EMBL	AC091980	http://www.ebi.ac.uk/ena/data/view/AC091980
EMBL	AF222747	http://www.ebi.ac.uk/ena/data/view/AF222747
EMBL	AJ288952	http://www.ebi.ac.uk/ena/data/view/AJ288952
EMBL	AJ288953	http://www.ebi.ac.uk/ena/data/view/AJ288953
EMBL	AJ288955	http://www.ebi.ac.uk/ena/data/view/AJ288955
EMBL	AK027880	http://www.ebi.ac.uk/ena/data/view/AK027880
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
Ensembl	ENST00000389118	http://www.ensembl.org/id/ENST00000389118
Ensembl	ENST00000519256	http://www.ensembl.org/id/ENST00000519256
Ensembl	ENST00000519949	http://www.ensembl.org/id/ENST00000519949
Ensembl	ENST00000522533	http://www.ensembl.org/id/ENST00000522533
Ensembl	ENST00000523189	http://www.ensembl.org/id/ENST00000523189
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005643	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005643
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_function	GO:0005049	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005049
GO_function	GO:0005525	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525
GO_function	GO:0008536	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008536
GO_process	GO:0006606	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006606
GO_process	GO:0006611	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006611
GO_process	GO:0051028	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051028
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
GeneCards	RANBP17	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=RANBP17
GeneID	64901	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64901
GeneTree	ENSGT00730000110927	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00730000110927
HGNC	HGNC:14428	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14428
HOGENOM	HOG000139593	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000139593&db=HOGENOM6
HOVERGEN	HBG018869	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG018869&db=HOVERGEN
HPA	HPA029568	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA029568
HPA	HPA029569	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA029569
InParanoid	Q9H2T7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9H2T7
InterPro	IPR001494	http://www.ebi.ac.uk/interpro/entry/IPR001494
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
Jabion	64901	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=64901
KEGG_Gene	hsa:64901	http://www.genome.jp/dbget-bin/www_bget?hsa:64901
MIM	606141	http://www.ncbi.nlm.nih.gov/omim/606141
OMA	MDTGLPQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MDTGLPQ
OrthoDB	EOG091G0ONG	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0ONG
PSORT	swissprot:RBP17_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:RBP17_HUMAN
PSORT-B	swissprot:RBP17_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:RBP17_HUMAN
PSORT2	swissprot:RBP17_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:RBP17_HUMAN
Pfam	PF03810	http://pfam.xfam.org/family/PF03810
PharmGKB	PA34208	http://www.pharmgkb.org/do/serve?objId=PA34208&objCls=Gene
Phobius	swissprot:RBP17_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:RBP17_HUMAN
PhylomeDB	Q9H2T7	http://phylomedb.org/?seqid=Q9H2T7
ProteinModelPortal	Q9H2T7	http://www.proteinmodelportal.org/query/uniprot/Q9H2T7
PubMed	11024021	http://www.ncbi.nlm.nih.gov/pubmed/11024021
PubMed	11071879	http://www.ncbi.nlm.nih.gov/pubmed/11071879
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
RefSeq	NP_075048	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_075048
SMART	SM00913	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00913
STRING	9606.ENSP00000427975	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000427975&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
TCDB	1.I.1.1	http://www.tcdb.org/search/result.php?tc=1.I.1.1
UCSC	uc003mba	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003mba&org=rat
UniGene	Hs.410810	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.410810
UniProtKB	RBP17_HUMAN	http://www.uniprot.org/uniprot/RBP17_HUMAN
UniProtKB-AC	Q9H2T7	http://www.uniprot.org/uniprot/Q9H2T7
charge	swissprot:RBP17_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:RBP17_HUMAN
eggNOG	ENOG410XRPR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRPR
eggNOG	KOG1410	http://eggnogapi.embl.de/nog_data/html/tree/KOG1410
epestfind	swissprot:RBP17_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:RBP17_HUMAN
garnier	swissprot:RBP17_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:RBP17_HUMAN
helixturnhelix	swissprot:RBP17_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:RBP17_HUMAN
hmoment	swissprot:RBP17_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:RBP17_HUMAN
iep	swissprot:RBP17_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:RBP17_HUMAN
inforesidue	swissprot:RBP17_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:RBP17_HUMAN
neXtProt	NX_Q9H2T7	http://www.nextprot.org/db/entry/NX_Q9H2T7
octanol	swissprot:RBP17_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:RBP17_HUMAN
pepcoil	swissprot:RBP17_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:RBP17_HUMAN
pepdigest	swissprot:RBP17_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:RBP17_HUMAN
pepinfo	swissprot:RBP17_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:RBP17_HUMAN
pepnet	swissprot:RBP17_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:RBP17_HUMAN
pepstats	swissprot:RBP17_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:RBP17_HUMAN
pepwheel	swissprot:RBP17_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:RBP17_HUMAN
pepwindow	swissprot:RBP17_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:RBP17_HUMAN
sigcleave	swissprot:RBP17_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:RBP17_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ABCA5_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8WWZ7-1; Sequence=Displayed; Name=2; Synonyms=V20+16; IsoId=Q8WWZ7-2; Sequence=VSP_020691, VSP_020692; Name=3; IsoId=Q8WWZ7-3; Sequence=VSP_020690; Note=No experimental confirmation available.; 
# BioGrid	117024	2
# CCDS	CCDS11685	-. [Q8WWZ7-1]
# ChiTaRS	ABCA5	human
# DEVELOPMENTAL STAGE	Expressed in fetal liver, kidney and brain. {ECO	0000269|Ref.1}. 
# DrugBank	DB00864	Tacrolimus
# Ensembl	ENST00000392676	ENSP00000376443; ENSG00000154265. [Q8WWZ7-1]
# Ensembl	ENST00000588877	ENSP00000467882; ENSG00000154265. [Q8WWZ7-1]
# ExpressionAtlas	Q8WWZ7	baseline and differential
# FUNCTION	ABCA5_HUMAN	May play a role in the processing of autolysosomes. {ECO 0000250}. 
# GO_component	GO:0000139	Golgi membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005764	lysosome; ISS:BHF-UCL.
# GO_component	GO:0005765	lysosomal membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005770	late endosome; ISS:BHF-UCL.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0031902	late endosome membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IBA:GO_Central.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; IBA:GO_Central.
# GO_process	GO:0006869	lipid transport; IBA:GO_Central.
# GO_process	GO:0010745	negative regulation of macrophage derived foam cell differentiation; ISS:BHF-UCL.
# GO_process	GO:0033344	cholesterol efflux; ISS:BHF-UCL.
# GO_process	GO:0034375	high-density lipoprotein particle remodeling; ISS:BHF-UCL.
# GO_process	GO:0043691	reverse cholesterol transport; IC:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005764	lysosome
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Gene3D	3.40.50.300	-; 2.
# Genevisible	Q8WWZ7	HS
# HGNC	HGNC:35	ABCA5
# IntAct	Q8WWZ7	2
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR026082	ABC_A
# InterPro	IPR027417	P-loop_NTPase
# InterPro	IPR030367	ABCA5
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko02010	ABC transporters
# MIM	612503	gene
# Organism	ABCA5_HUMAN	Homo sapiens (Human)
# Orphanet	2026	Gingival fibromatosis-hypertrichosis syndrome
# PANTHER	PTHR19229	PTHR19229
# PANTHER	PTHR19229:SF100	PTHR19229:SF100
# PROSITE	PS00211	ABC_TRANSPORTER_1
# PROSITE	PS50893	ABC_TRANSPORTER_2; 2
# PTM	ABCA5_HUMAN	N-glycosylated. {ECO 0000250}. 
# Pfam	PF00005	ABC_tran; 2
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-1369062	ABC transporters in lipid homeostasis
# RecName	ABCA5_HUMAN	ATP-binding cassette sub-family A member 5
# RefSeq	NP_061142	NM_018672.4. [Q8WWZ7-1]
# RefSeq	NP_758424	NM_172232.3. [Q8WWZ7-1]
# SEQUENCE CAUTION	Sequence=BAB71700.1; Type=Erroneous initiation; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCA family. {ECO	0000305}. 
# SIMILARITY	Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA; 2
# SUBCELLULAR LOCATION	ABCA5_HUMAN	Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUPFAM	SSF52540	SSF52540; 2
# TCDB	3.A.1.211	the atp-binding cassette (abc) superfamily
# TISSUE SPECIFICITY	Ubiquitously expressed. Highly expressed in testis, skeletal muscle, kidney, liver and placenta. {ECO:0000269|PubMed	12504089, ECO:0000269|Ref.1}. 
# UCSC	uc002jif	human. [Q8WWZ7-1]
# WEB RESOURCE	ABCA5_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=Q8WWZ7";
# eggNOG	COG1131	LUCA
# eggNOG	KOG0059	Eukaryota
BLAST	swissprot:ABCA5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCA5_HUMAN
BioCyc	ZFISH:ENSG00000154265-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000154265-MONOMER
COXPRESdb	23461	http://coxpresdb.jp/data/gene/23461.shtml
CleanEx	HS_ABCA5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCA5
DOI	10.1016/S0006-291X(02)02827-9	http://dx.doi.org/10.1016/S0006-291X(02)02827-9
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/dnares/8.4.179	http://dx.doi.org/10.1093/dnares/8.4.179
DrugBank	DB00864	http://www.drugbank.ca/drugs/DB00864
EMBL	AB067475	http://www.ebi.ac.uk/ena/data/view/AB067475
EMBL	AJ275973	http://www.ebi.ac.uk/ena/data/view/AJ275973
EMBL	AJ512612	http://www.ebi.ac.uk/ena/data/view/AJ512612
EMBL	AK056533	http://www.ebi.ac.uk/ena/data/view/AK056533
EMBL	AK058170	http://www.ebi.ac.uk/ena/data/view/AK058170
EMBL	AY028897	http://www.ebi.ac.uk/ena/data/view/AY028897
Ensembl	ENST00000392676	http://www.ensembl.org/id/ENST00000392676
Ensembl	ENST00000588877	http://www.ensembl.org/id/ENST00000588877
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005770	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005770
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0031902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031902
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GO_process	GO:0006869	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006869
GO_process	GO:0010745	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010745
GO_process	GO:0033344	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033344
GO_process	GO:0034375	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034375
GO_process	GO:0043691	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043691
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCA5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCA5
GeneID	23461	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23461
GeneTree	ENSGT00760000118965	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118965
HGNC	HGNC:35	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:35
HOGENOM	HOG000231057	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231057&db=HOGENOM6
HOVERGEN	HBG079884	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG079884&db=HOVERGEN
HPA	HPA022032	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA022032
HPA	HPA062904	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA062904
InParanoid	Q8WWZ7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8WWZ7
IntAct	Q8WWZ7	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8WWZ7*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR026082	http://www.ebi.ac.uk/interpro/entry/IPR026082
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
InterPro	IPR030367	http://www.ebi.ac.uk/interpro/entry/IPR030367
Jabion	23461	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=23461
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:23461	http://www.genome.jp/dbget-bin/www_bget?hsa:23461
KEGG_Orthology	KO:K05648	http://www.genome.jp/dbget-bin/www_bget?KO:K05648
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
MIM	612503	http://www.ncbi.nlm.nih.gov/omim/612503
OMA	YIDRYCA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YIDRYCA
Orphanet	2026	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=2026
OrthoDB	EOG091G00AG	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00AG
PANTHER	PTHR19229	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19229
PANTHER	PTHR19229:SF100	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19229:SF100
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PSORT	swissprot:ABCA5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCA5_HUMAN
PSORT-B	swissprot:ABCA5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCA5_HUMAN
PSORT2	swissprot:ABCA5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCA5_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
PharmGKB	PA24380	http://www.pharmgkb.org/do/serve?objId=PA24380&objCls=Gene
Phobius	swissprot:ABCA5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCA5_HUMAN
PhylomeDB	Q8WWZ7	http://phylomedb.org/?seqid=Q8WWZ7
ProteinModelPortal	Q8WWZ7	http://www.proteinmodelportal.org/query/uniprot/Q8WWZ7
PubMed	11572484	http://www.ncbi.nlm.nih.gov/pubmed/11572484
PubMed	12504089	http://www.ncbi.nlm.nih.gov/pubmed/12504089
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
Reactome	R-HSA-1369062	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1369062
RefSeq	NP_061142	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061142
RefSeq	NP_758424	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_758424
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	Q8WWZ7	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8WWZ7
STRING	9606.ENSP00000376443	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000376443&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TCDB	3.A.1.211	http://www.tcdb.org/search/result.php?tc=3.A.1.211
UCSC	uc002jif	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002jif&org=rat
UniGene	Hs.731824	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.731824
UniProtKB	ABCA5_HUMAN	http://www.uniprot.org/uniprot/ABCA5_HUMAN
UniProtKB-AC	Q8WWZ7	http://www.uniprot.org/uniprot/Q8WWZ7
charge	swissprot:ABCA5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCA5_HUMAN
eggNOG	COG1131	http://eggnogapi.embl.de/nog_data/html/tree/COG1131
eggNOG	KOG0059	http://eggnogapi.embl.de/nog_data/html/tree/KOG0059
epestfind	swissprot:ABCA5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCA5_HUMAN
garnier	swissprot:ABCA5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCA5_HUMAN
helixturnhelix	swissprot:ABCA5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCA5_HUMAN
hmoment	swissprot:ABCA5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCA5_HUMAN
iep	swissprot:ABCA5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCA5_HUMAN
inforesidue	swissprot:ABCA5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCA5_HUMAN
neXtProt	NX_Q8WWZ7	http://www.nextprot.org/db/entry/NX_Q8WWZ7
octanol	swissprot:ABCA5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCA5_HUMAN
pepcoil	swissprot:ABCA5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCA5_HUMAN
pepdigest	swissprot:ABCA5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCA5_HUMAN
pepinfo	swissprot:ABCA5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCA5_HUMAN
pepnet	swissprot:ABCA5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCA5_HUMAN
pepstats	swissprot:ABCA5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCA5_HUMAN
pepwheel	swissprot:ABCA5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCA5_HUMAN
pepwindow	swissprot:ABCA5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCA5_HUMAN
sigcleave	swissprot:ABCA5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCA5_HUMAN
## Database	ID	URL or Descriptions
# AltName	AAA1_HUMAN	Solute carrier family 7 member 10
# Ensembl	ENST00000253188	ENSP00000253188; ENSG00000130876
# ExpressionAtlas	Q9NS82	baseline and differential
# FUNCTION	AAA1_HUMAN	Sodium-independent, high affinity transport of small neutral D- and L-amino acids. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse. {ECO 0000269|PubMed 10863037}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; NAS:UniProtKB.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_function	GO:0015175	neutral amino acid transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015194	L-serine transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0015297	antiporter activity; IBA:GO_Central.
# GO_process	GO:0006865	amino acid transport; TAS:Reactome.
# GO_process	GO:0015804	neutral amino acid transport; IDA:UniProtKB.
# GO_process	GO:0042941	D-alanine transport; IBA:GO_Central.
# GO_process	GO:0042942	D-serine transport; IBA:GO_Central.
# GO_process	GO:0050900	leukocyte migration; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0048870	cell motility
# Genevisible	Q9NS82	HS
# HGNC	HGNC:11058	SLC7A10
# InterPro	IPR002293	AA/rel_permease1
# KEGG_Brite	ko02001	Solute carrier family
# MIM	607959	gene
# Organism	AAA1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11785	PTHR11785
# PIRSF	PIRSF006060	AA_transporter
# Pfam	PF13520	AA_permease_2
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-210991	Basigin interactions
# Reactome	R-HSA-352230	Amino acid transport across the plasma membrane
# RecName	AAA1_HUMAN	Asc-type amino acid transporter 1
# RefSeq	NP_062823	NM_019849.2
# SIMILARITY	Belongs to the amino acid-polyamine-organocation (APC) superfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	AAA1_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUBUNIT	Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc. {ECO:0000250|UniProtKB	Q9JMH8}. 
# TCDB	2.A.3.8.21	the amino acid-polyamine-organocation (apc) family
# TISSUE SPECIFICITY	Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle. {ECO:0000269|PubMed	10863037}. 
# UCSC	uc002num	human
# eggNOG	COG0531	LUCA
# eggNOG	KOG1287	Eukaryota
BLAST	swissprot:AAA1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AAA1_HUMAN
BioCyc	ZFISH:ENSG00000130876-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000130876-MONOMER
COXPRESdb	56301	http://coxpresdb.jp/data/gene/56301.shtml
CleanEx	HS_SLC7A10	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC7A10
DOI	10.1006/mgme.2001.3209	http://dx.doi.org/10.1006/mgme.2001.3209
DOI	10.1016/S0304-3940(00)01169-1	http://dx.doi.org/10.1016/S0304-3940(00)01169-1
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB037670	http://www.ebi.ac.uk/ena/data/view/AB037670
EMBL	AF340155	http://www.ebi.ac.uk/ena/data/view/AF340155
EMBL	AF340156	http://www.ebi.ac.uk/ena/data/view/AF340156
EMBL	AF340157	http://www.ebi.ac.uk/ena/data/view/AF340157
EMBL	AF340158	http://www.ebi.ac.uk/ena/data/view/AF340158
EMBL	AF340159	http://www.ebi.ac.uk/ena/data/view/AF340159
EMBL	AF340160	http://www.ebi.ac.uk/ena/data/view/AF340160
EMBL	AF340161	http://www.ebi.ac.uk/ena/data/view/AF340161
EMBL	AF340162	http://www.ebi.ac.uk/ena/data/view/AF340162
EMBL	AF340163	http://www.ebi.ac.uk/ena/data/view/AF340163
EMBL	AF340164	http://www.ebi.ac.uk/ena/data/view/AF340164
EMBL	AF340165	http://www.ebi.ac.uk/ena/data/view/AF340165
EMBL	AJ277731	http://www.ebi.ac.uk/ena/data/view/AJ277731
EMBL	AK316594	http://www.ebi.ac.uk/ena/data/view/AK316594
EMBL	BC035627	http://www.ebi.ac.uk/ena/data/view/BC035627
Ensembl	ENST00000253188	http://www.ensembl.org/id/ENST00000253188
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0015175	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015175
GO_function	GO:0015194	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015194
GO_function	GO:0015297	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GO_process	GO:0015804	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015804
GO_process	GO:0042941	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042941
GO_process	GO:0042942	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042942
GO_process	GO:0050900	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050900
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GeneCards	SLC7A10	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC7A10
GeneID	56301	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56301
GeneTree	ENSGT00760000119037	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119037
HGNC	HGNC:11058	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11058
HOGENOM	HOG000098892	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000098892&db=HOGENOM6
HOVERGEN	HBG000476	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000476&db=HOVERGEN
HPA	HPA041884	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA041884
HPA	HPA057036	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA057036
InParanoid	Q9NS82	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NS82
IntAct	Q9NS82	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NS82*
InterPro	IPR002293	http://www.ebi.ac.uk/interpro/entry/IPR002293
Jabion	56301	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=56301
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:56301	http://www.genome.jp/dbget-bin/www_bget?hsa:56301
KEGG_Orthology	KO:K13782	http://www.genome.jp/dbget-bin/www_bget?KO:K13782
MIM	607959	http://www.ncbi.nlm.nih.gov/omim/607959
OMA	TESMTHW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TESMTHW
OrthoDB	EOG091G07EM	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07EM
PANTHER	PTHR11785	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785
PSORT	swissprot:AAA1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AAA1_HUMAN
PSORT-B	swissprot:AAA1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AAA1_HUMAN
PSORT2	swissprot:AAA1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AAA1_HUMAN
Pfam	PF13520	http://pfam.xfam.org/family/PF13520
PharmGKB	PA35918	http://www.pharmgkb.org/do/serve?objId=PA35918&objCls=Gene
Phobius	swissprot:AAA1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AAA1_HUMAN
PhylomeDB	Q9NS82	http://phylomedb.org/?seqid=Q9NS82
ProteinModelPortal	Q9NS82	http://www.proteinmodelportal.org/query/uniprot/Q9NS82
PubMed	10863037	http://www.ncbi.nlm.nih.gov/pubmed/10863037
PubMed	11509015	http://www.ncbi.nlm.nih.gov/pubmed/11509015
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-210991	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-210991
Reactome	R-HSA-352230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-352230
RefSeq	NP_062823	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_062823
STRING	9606.ENSP00000253188	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000253188&targetmode=cogs
TCDB	2.A.3.8.21	http://www.tcdb.org/search/result.php?tc=2.A.3.8.21
UCSC	uc002num	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002num&org=rat
UniGene	Hs.58679	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.58679
UniProtKB	AAA1_HUMAN	http://www.uniprot.org/uniprot/AAA1_HUMAN
UniProtKB-AC	Q9NS82	http://www.uniprot.org/uniprot/Q9NS82
charge	swissprot:AAA1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AAA1_HUMAN
eggNOG	COG0531	http://eggnogapi.embl.de/nog_data/html/tree/COG0531
eggNOG	KOG1287	http://eggnogapi.embl.de/nog_data/html/tree/KOG1287
epestfind	swissprot:AAA1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AAA1_HUMAN
garnier	swissprot:AAA1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AAA1_HUMAN
helixturnhelix	swissprot:AAA1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AAA1_HUMAN
hmoment	swissprot:AAA1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AAA1_HUMAN
iep	swissprot:AAA1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AAA1_HUMAN
inforesidue	swissprot:AAA1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AAA1_HUMAN
neXtProt	NX_Q9NS82	http://www.nextprot.org/db/entry/NX_Q9NS82
octanol	swissprot:AAA1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AAA1_HUMAN
pepcoil	swissprot:AAA1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AAA1_HUMAN
pepdigest	swissprot:AAA1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AAA1_HUMAN
pepinfo	swissprot:AAA1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AAA1_HUMAN
pepnet	swissprot:AAA1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AAA1_HUMAN
pepstats	swissprot:AAA1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AAA1_HUMAN
pepwheel	swissprot:AAA1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AAA1_HUMAN
pepwindow	swissprot:AAA1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AAA1_HUMAN
sigcleave	swissprot:AAA1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AAA1_HUMAN
## Database	ID	URL or Descriptions
# AltName	COX8C_HUMAN	Cytochrome c oxidase polypeptide 8 isoform 3
# AltName	COX8C_HUMAN	Cytochrome c oxidase polypeptide VIII isoform 3
# AltName	COX8C_HUMAN	Cytochrome c oxidase subunit 8-3
# AltName	COX8C_HUMAN	Cytochrome c oxidase subunit VIIIC
# Ensembl	ENST00000342144	ENSP00000340568; ENSG00000187581
# Ensembl	ENST00000620478	ENSP00000480706; ENSG00000277018
# FUNCTION	COX8C_HUMAN	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. 
# GO_component	GO:0005739	mitochondrion; IDA:MGI.
# GO_component	GO:0005751	mitochondrial respiratory chain complex IV; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0004129	cytochrome-c oxidase activity; IBA:GO_Central.
# GO_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen; IBA:GO_Central.
# GO_process	GO:1902600	hydrogen ion transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	4.10.81.10	-; 1.
# Genevisible	Q7Z4L0	HS
# HGNC	HGNC:24382	COX8C
# InterPro	IPR003205	Cyt_c_oxidase_su8
# InterPro	IPR016070	Cyt_c_oxidase_su8/PSI_RC_su9
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	616855	gene
# Organism	COX8C_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR16717	PTHR16717
# Pfam	PF02285	COX8
# Proteomes	UP000005640	Chromosome 14
# RecName	COX8C_HUMAN	Cytochrome c oxidase subunit 8C, mitochondrial
# RefSeq	NP_892016	NM_182971.2
# SIMILARITY	Belongs to the cytochrome c oxidase VIII family. {ECO	0000305}.
# SUBCELLULAR LOCATION	COX8C_HUMAN	Mitochondrion inner membrane. 
# SUPFAM	SSF81431	SSF81431
# TCDB	3.D.4.11	the proton-translocating cytochrome oxidase (cox) superfamily
# TISSUE SPECIFICITY	COX8C_HUMAN	It is not yet known where COX8C is expressed. 
# UCSC	uc001ybt	human
# eggNOG	ENOG410JK2D	Eukaryota
# eggNOG	ENOG41114SW	LUCA
BLAST	swissprot:COX8C_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:COX8C_HUMAN
BioCyc	ZFISH:G66-31869-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31869-MONOMER
COXPRESdb	341947	http://coxpresdb.jp/data/gene/341947.shtml
CleanEx	HS_COX8C	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_COX8C
DOI	10.1016/S0378-1119(03)00604-8	http://dx.doi.org/10.1016/S0378-1119(03)00604-8
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AY161004	http://www.ebi.ac.uk/ena/data/view/AY161004
EMBL	BC101125	http://www.ebi.ac.uk/ena/data/view/BC101125
EMBL	BC101126	http://www.ebi.ac.uk/ena/data/view/BC101126
Ensembl	ENST00000342144	http://www.ensembl.org/id/ENST00000342144
Ensembl	ENST00000620478	http://www.ensembl.org/id/ENST00000620478
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005751	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005751
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0004129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004129
GO_process	GO:0006123	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006123
GO_process	GO:1902600	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902600
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	4.10.81.10	http://www.cathdb.info/version/latest/superfamily/4.10.81.10
GeneCards	COX8C	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=COX8C
GeneID	341947	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=341947
GeneTree	ENSGT00390000012036	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000012036
HGNC	HGNC:24382	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:24382
HOGENOM	HOG000111895	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000111895&db=HOGENOM6
HPA	HPA003127	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA003127
InParanoid	Q7Z4L0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q7Z4L0
InterPro	IPR003205	http://www.ebi.ac.uk/interpro/entry/IPR003205
InterPro	IPR016070	http://www.ebi.ac.uk/interpro/entry/IPR016070
Jabion	341947	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=341947
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Gene	hsa:341947	http://www.genome.jp/dbget-bin/www_bget?hsa:341947
KEGG_Orthology	KO:K02273	http://www.genome.jp/dbget-bin/www_bget?KO:K02273
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	616855	http://www.ncbi.nlm.nih.gov/omim/616855
OMA	CPARRHY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CPARRHY
OrthoDB	EOG091G1A16	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G1A16
PANTHER	PTHR16717	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16717
PSORT	swissprot:COX8C_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:COX8C_HUMAN
PSORT-B	swissprot:COX8C_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:COX8C_HUMAN
PSORT2	swissprot:COX8C_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:COX8C_HUMAN
Pfam	PF02285	http://pfam.xfam.org/family/PF02285
PharmGKB	PA134909890	http://www.pharmgkb.org/do/serve?objId=PA134909890&objCls=Gene
Phobius	swissprot:COX8C_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:COX8C_HUMAN
PhylomeDB	Q7Z4L0	http://phylomedb.org/?seqid=Q7Z4L0
ProteinModelPortal	Q7Z4L0	http://www.proteinmodelportal.org/query/uniprot/Q7Z4L0
PubMed	12909344	http://www.ncbi.nlm.nih.gov/pubmed/12909344
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
RefSeq	NP_892016	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_892016
SMR	Q7Z4L0	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q7Z4L0
STRING	9606.ENSP00000340568	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000340568&targetmode=cogs
SUPFAM	SSF81431	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81431
TCDB	3.D.4.11	http://www.tcdb.org/search/result.php?tc=3.D.4.11
UCSC	uc001ybt	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001ybt&org=rat
UniGene	Hs.666459	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.666459
UniProtKB	COX8C_HUMAN	http://www.uniprot.org/uniprot/COX8C_HUMAN
UniProtKB-AC	Q7Z4L0	http://www.uniprot.org/uniprot/Q7Z4L0
charge	swissprot:COX8C_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:COX8C_HUMAN
eggNOG	ENOG410JK2D	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410JK2D
eggNOG	ENOG41114SW	http://eggnogapi.embl.de/nog_data/html/tree/ENOG41114SW
epestfind	swissprot:COX8C_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:COX8C_HUMAN
garnier	swissprot:COX8C_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:COX8C_HUMAN
helixturnhelix	swissprot:COX8C_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:COX8C_HUMAN
hmoment	swissprot:COX8C_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:COX8C_HUMAN
iep	swissprot:COX8C_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:COX8C_HUMAN
inforesidue	swissprot:COX8C_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:COX8C_HUMAN
neXtProt	NX_Q7Z4L0	http://www.nextprot.org/db/entry/NX_Q7Z4L0
octanol	swissprot:COX8C_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:COX8C_HUMAN
pepcoil	swissprot:COX8C_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:COX8C_HUMAN
pepdigest	swissprot:COX8C_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:COX8C_HUMAN
pepinfo	swissprot:COX8C_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:COX8C_HUMAN
pepnet	swissprot:COX8C_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:COX8C_HUMAN
pepstats	swissprot:COX8C_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:COX8C_HUMAN
pepwheel	swissprot:COX8C_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:COX8C_HUMAN
pepwindow	swissprot:COX8C_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:COX8C_HUMAN
sigcleave	swissprot:COX8C_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:COX8C_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AT131_HUMAN	Event=Alternative splicing; Named isoforms=3; Comment=Experimental confirmation may be lacking for some isoforms.; Name=A; IsoId=Q9HD20-1; Sequence=Displayed; Name=B; IsoId=Q9HD20-2; Sequence=VSP_000434, VSP_000435; Name=C; IsoId=Q9HD20-3; Sequence=VSP_000433; 
# BioGrid	121393	10
# CATALYTIC ACTIVITY	AT131_HUMAN	ATP + H(2)O = ADP + phosphate. 
# CCDS	CCDS32970	-. [Q9HD20-1]
# ChiTaRS	ATP13A1	human
# Ensembl	ENST00000291503	ENSP00000291503; ENSG00000105726. [Q9HD20-2]
# Ensembl	ENST00000357324	ENSP00000349877; ENSG00000105726. [Q9HD20-1]
# ExpressionAtlas	Q9HD20	baseline and differential
# FUNCTION	AT131_HUMAN	Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis. {ECO 0000269|PubMed 24392018}. 
# GO_component	GO:0005789	endoplasmic reticulum membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IBA:GO_Central.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0015410	manganese-transporting ATPase activity; TAS:Reactome.
# GO_function	GO:0019829	cation-transporting ATPase activity; IBA:GO_Central.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0006874	cellular calcium ion homeostasis; IBA:GO_Central.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.70.150.10	-; 1.
# Gene3D	3.40.1110.10	-; 1.
# Gene3D	3.40.50.1000	-; 2.
# Genevisible	Q9HD20	HS
# HGNC	HGNC:24215	ATP13A1
# IntAct	Q9HD20	8
# InterPro	IPR001757	P_typ_ATPase
# InterPro	IPR006544	P-type_TPase_V
# InterPro	IPR008250	ATPase_P-typ_transduc_dom_A
# InterPro	IPR018303	ATPase_P-typ_P_site
# InterPro	IPR023214	HAD-like_dom
# InterPro	IPR023299	ATPase_P-typ_cyto_domN
# KEGG_Brite	ko01000	Enzymes
# MISCELLANEOUS	AT131_HUMAN	Depletion of ATP13A1 with siRNAs leads to induction of the unfolded protein response (UPR) and increased activity of glucosylceramide synthase (GlcCer). 
# Organism	AT131_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR24093:SF82	PTHR24093:SF82; 3
# PROSITE	PS00154	ATPASE_E1_E2
# Pfam	PF00122	E1-E2_ATPase
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	AT131_HUMAN	Manganese-transporting ATPase 13A1
# RefSeq	NP_065143	NM_020410.2. [Q9HD20-1]
# SEQUENCE CAUTION	Sequence=AAH69211.1; Type=Frameshift; Positions=846; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	AT131_HUMAN	Endoplasmic reticulum membrane {ECO 0000269|PubMed 24392018}; Multi-pass membrane protein {ECO 0000269|PubMed 24392018}. 
# SUPFAM	SSF56784	SSF56784; 3
# SUPFAM	SSF81660	SSF81660
# TCDB	3.A.3.10.19	the p-type atpase (p-atpase) superfamily
# TIGRFAMs	TIGR01494	ATPase_P-type; 2
# TIGRFAMs	TIGR01657	P-ATPase-V
# UCSC	uc002nng	human. [Q9HD20-1]
# eggNOG	COG0474	LUCA
# eggNOG	KOG0209	Eukaryota
BLAST	swissprot:AT131_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AT131_HUMAN
BioCyc	ZFISH:ENSG00000105726-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000105726-MONOMER
COXPRESdb	57130	http://coxpresdb.jp/data/gene/57130.shtml
CleanEx	HS_ATP13A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP13A1
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr0502065	http://dx.doi.org/10.1021/pr0502065
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1074/mcp.M111.015131	http://dx.doi.org/10.1074/mcp.M111.015131
DOI	10.1093/dnares/8.2.85	http://dx.doi.org/10.1093/dnares/8.2.85
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1371/journal.pone.0085519	http://dx.doi.org/10.1371/journal.pone.0085519
EC_number	EC:3.6.3.-	http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.-
EMBL	AB058728	http://www.ebi.ac.uk/ena/data/view/AB058728
EMBL	AF288687	http://www.ebi.ac.uk/ena/data/view/AF288687
EMBL	AK026044	http://www.ebi.ac.uk/ena/data/view/AK026044
EMBL	AK056420	http://www.ebi.ac.uk/ena/data/view/AK056420
EMBL	AK095287	http://www.ebi.ac.uk/ena/data/view/AK095287
EMBL	AK172778	http://www.ebi.ac.uk/ena/data/view/AK172778
EMBL	BC009302	http://www.ebi.ac.uk/ena/data/view/BC009302
EMBL	BC069211	http://www.ebi.ac.uk/ena/data/view/BC069211
EMBL	CH471106	http://www.ebi.ac.uk/ena/data/view/CH471106
EMBL	CH471106	http://www.ebi.ac.uk/ena/data/view/CH471106
ENZYME	3.6.3.-	http://enzyme.expasy.org/EC/3.6.3.-
Ensembl	ENST00000291503	http://www.ensembl.org/id/ENST00000291503
Ensembl	ENST00000357324	http://www.ensembl.org/id/ENST00000357324
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0015410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015410
GO_function	GO:0019829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019829
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.70.150.10	http://www.cathdb.info/version/latest/superfamily/2.70.150.10
Gene3D	3.40.1110.10	http://www.cathdb.info/version/latest/superfamily/3.40.1110.10
Gene3D	3.40.50.1000	http://www.cathdb.info/version/latest/superfamily/3.40.50.1000
GeneCards	ATP13A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP13A1
GeneID	57130	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57130
GeneTree	ENSGT00550000075064	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000075064
HGNC	HGNC:24215	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:24215
HOGENOM	HOG000199432	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000199432&db=HOGENOM6
HOVERGEN	HBG050602	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050602&db=HOVERGEN
HPA	HPA031798	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031798
HPA	HPA049717	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA049717
InParanoid	Q9HD20	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9HD20
IntAct	Q9HD20	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9HD20*
IntEnz	3.6.3	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3
InterPro	IPR001757	http://www.ebi.ac.uk/interpro/entry/IPR001757
InterPro	IPR006544	http://www.ebi.ac.uk/interpro/entry/IPR006544
InterPro	IPR008250	http://www.ebi.ac.uk/interpro/entry/IPR008250
InterPro	IPR018303	http://www.ebi.ac.uk/interpro/entry/IPR018303
InterPro	IPR023214	http://www.ebi.ac.uk/interpro/entry/IPR023214
InterPro	IPR023299	http://www.ebi.ac.uk/interpro/entry/IPR023299
Jabion	57130	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=57130
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:57130	http://www.genome.jp/dbget-bin/www_bget?hsa:57130
KEGG_Orthology	KO:K14950	http://www.genome.jp/dbget-bin/www_bget?KO:K14950
OMA	YLYSEAQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YLYSEAQ
OrthoDB	EOG091G00UD	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00UD
PANTHER	PTHR24093:SF82	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24093:SF82
PROSITE	PS00154	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00154
PSORT	swissprot:AT131_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AT131_HUMAN
PSORT-B	swissprot:AT131_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AT131_HUMAN
PSORT2	swissprot:AT131_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AT131_HUMAN
Pfam	PF00122	http://pfam.xfam.org/family/PF00122
PharmGKB	PA134988892	http://www.pharmgkb.org/do/serve?objId=PA134988892&objCls=Gene
Phobius	swissprot:AT131_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AT131_HUMAN
PhylomeDB	Q9HD20	http://phylomedb.org/?seqid=Q9HD20
ProteinModelPortal	Q9HD20	http://www.proteinmodelportal.org/query/uniprot/Q9HD20
PubMed	11347906	http://www.ncbi.nlm.nih.gov/pubmed/11347906
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16335952	http://www.ncbi.nlm.nih.gov/pubmed/16335952
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22223895	http://www.ncbi.nlm.nih.gov/pubmed/22223895
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	24392018	http://www.ncbi.nlm.nih.gov/pubmed/24392018
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_065143	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_065143
STRING	9606.ENSP00000349877	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000349877&targetmode=cogs
SUPFAM	SSF56784	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784
SUPFAM	SSF81660	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81660
TCDB	3.A.3.10.19	http://www.tcdb.org/search/result.php?tc=3.A.3.10.19
TIGRFAMs	TIGR01494	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01494
TIGRFAMs	TIGR01657	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01657
UCSC	uc002nng	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002nng&org=rat
UniGene	Hs.501794	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.501794
UniProtKB	AT131_HUMAN	http://www.uniprot.org/uniprot/AT131_HUMAN
UniProtKB-AC	Q9HD20	http://www.uniprot.org/uniprot/Q9HD20
charge	swissprot:AT131_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AT131_HUMAN
eggNOG	COG0474	http://eggnogapi.embl.de/nog_data/html/tree/COG0474
eggNOG	KOG0209	http://eggnogapi.embl.de/nog_data/html/tree/KOG0209
epestfind	swissprot:AT131_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AT131_HUMAN
garnier	swissprot:AT131_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AT131_HUMAN
helixturnhelix	swissprot:AT131_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AT131_HUMAN
hmoment	swissprot:AT131_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AT131_HUMAN
iep	swissprot:AT131_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AT131_HUMAN
inforesidue	swissprot:AT131_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AT131_HUMAN
neXtProt	NX_Q9HD20	http://www.nextprot.org/db/entry/NX_Q9HD20
octanol	swissprot:AT131_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AT131_HUMAN
pepcoil	swissprot:AT131_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AT131_HUMAN
pepdigest	swissprot:AT131_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AT131_HUMAN
pepinfo	swissprot:AT131_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AT131_HUMAN
pepnet	swissprot:AT131_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AT131_HUMAN
pepstats	swissprot:AT131_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AT131_HUMAN
pepwheel	swissprot:AT131_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AT131_HUMAN
pepwindow	swissprot:AT131_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AT131_HUMAN
sigcleave	swissprot:AT131_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AT131_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SO4A1_HUMAN	Event=Alternative splicing; Named isoforms=4; Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=Q96BD0-1; Sequence=Displayed; Name=2; IsoId=Q96BD0-2; Sequence=VSP_006152, VSP_006156; Name=3; IsoId=Q96BD0-3; Sequence=VSP_006153, VSP_006155; Name=4; IsoId=Q96BD0-4; Sequence=VSP_006154; 
# AltName	SO4A1_HUMAN	Colon organic anion transporter
# AltName	SO4A1_HUMAN	Organic anion transporter polypeptide-related protein 1
# AltName	SO4A1_HUMAN	Organic anion-transporting polypeptide E
# AltName	SO4A1_HUMAN	Sodium-independent organic anion transporter E
# AltName	SO4A1_HUMAN	Solute carrier family 21 member 12
# BioGrid	118180	4
# CCDS	CCDS13501	-. [Q96BD0-1]
# CDD	cd06174	MFS
# ChiTaRS	SLCO4A1	human
# DrugBank	DB00279	Liothyronine
# DrugBank	DB00286	Conjugated Estrogens
# DrugBank	DB00390	Digoxin
# DrugBank	DB00451	Levothyroxine
# DrugBank	DB00509	Dextrothyroxine
# DrugBank	DB00783	Estradiol
# DrugBank	DB00917	Dinoprostone
# DrugBank	DB01053	Benzylpenicillin
# DrugBank	DB01583	Liotrix
# Ensembl	ENST00000217159	ENSP00000217159; ENSG00000101187. [Q96BD0-1]
# Ensembl	ENST00000370507	ENSP00000359538; ENSG00000101187. [Q96BD0-1]
# ExpressionAtlas	Q96BD0	baseline and differential
# FUNCTION	SO4A1_HUMAN	Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0015347	sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015349	thyroid hormone transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0043252	sodium-independent organic anion transport; IBA:GO_Central.
# GO_process	GO:0070327	thyroid hormone transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q96BD0	HS
# HGNC	HGNC:10953	SLCO4A1
# IntAct	Q96BD0	5
# InterPro	IPR002350	Kazal_dom
# InterPro	IPR004156	OA_transporter
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02001	Solute carrier family
# MIM	612436	gene
# Organism	SO4A1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11388	PTHR11388
# PROSITE	PS50850	MFS
# PROSITE	PS51465	KAZAL_2
# Pfam	PF03137	OATP
# Pfam	PF07648	Kazal_2
# Proteomes	UP000005640	Chromosome 20
# Reactome	R-HSA-879518	Transport of organic anions
# RecName	SO4A1_HUMAN	Solute carrier organic anion transporter family member 4A1
# RefSeq	NP_057438	NM_016354.3. [Q96BD0-1]
# SEQUENCE CAUTION	Sequence=BAA91247.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the organo anion transporter (TC 2.A.60) family. {ECO	0000305}. 
# SIMILARITY	Contains 1 Kazal-like domain. {ECO:0000255|PROSITE- ProRule	PRU00798}. 
# SUBCELLULAR LOCATION	SO4A1_HUMAN	Cell membrane; Multi-pass membrane protein. 
# SUPFAM	SSF103473	SSF103473; 3
# TCDB	2.A.60.1	the organo anion transporter (oat) family
# TIGRFAMs	TIGR00805	oat
# TISSUE SPECIFICITY	SO4A1_HUMAN	Ubiquitous, with the exception of spleen and leukocytes. 
# UCSC	uc002ydb	human. [Q96BD0-1]
# eggNOG	ENOG410XRSF	LUCA
# eggNOG	KOG3626	Eukaryota
BLAST	swissprot:SO4A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SO4A1_HUMAN
BioCyc	ZFISH:ENSG00000101187-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000101187-MONOMER
COXPRESdb	28231	http://coxpresdb.jp/data/gene/28231.shtml
CleanEx	HS_SLCO4A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLCO4A1
DOI	10.1006/bbrc.2000.2922	http://dx.doi.org/10.1006/bbrc.2000.2922
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/414865a	http://dx.doi.org/10.1038/414865a
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1210/endo.142.5.8115	http://dx.doi.org/10.1210/endo.142.5.8115
DrugBank	DB00279	http://www.drugbank.ca/drugs/DB00279
DrugBank	DB00286	http://www.drugbank.ca/drugs/DB00286
DrugBank	DB00390	http://www.drugbank.ca/drugs/DB00390
DrugBank	DB00451	http://www.drugbank.ca/drugs/DB00451
DrugBank	DB00509	http://www.drugbank.ca/drugs/DB00509
DrugBank	DB00783	http://www.drugbank.ca/drugs/DB00783
DrugBank	DB00917	http://www.drugbank.ca/drugs/DB00917
DrugBank	DB01053	http://www.drugbank.ca/drugs/DB01053
DrugBank	DB01583	http://www.drugbank.ca/drugs/DB01583
EMBL	AB031051	http://www.ebi.ac.uk/ena/data/view/AB031051
EMBL	AF104334	http://www.ebi.ac.uk/ena/data/view/AF104334
EMBL	AF187817	http://www.ebi.ac.uk/ena/data/view/AF187817
EMBL	AF205072	http://www.ebi.ac.uk/ena/data/view/AF205072
EMBL	AK000551	http://www.ebi.ac.uk/ena/data/view/AK000551
EMBL	AK023410	http://www.ebi.ac.uk/ena/data/view/AK023410
EMBL	AL357033	http://www.ebi.ac.uk/ena/data/view/AL357033
EMBL	AL357033	http://www.ebi.ac.uk/ena/data/view/AL357033
EMBL	BC015727	http://www.ebi.ac.uk/ena/data/view/BC015727
Ensembl	ENST00000217159	http://www.ensembl.org/id/ENST00000217159
Ensembl	ENST00000370507	http://www.ensembl.org/id/ENST00000370507
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0015347	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015347
GO_function	GO:0015349	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015349
GO_process	GO:0043252	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043252
GO_process	GO:0070327	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070327
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLCO4A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLCO4A1
GeneID	28231	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=28231
GeneTree	ENSGT00760000119014	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119014
H-InvDB	HIX0015985	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0015985
H-InvDB	HIX0138058	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0138058
HGNC	HGNC:10953	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10953
HOVERGEN	HBG100565	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG100565&db=HOVERGEN
HPA	HPA030669	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA030669
HPA	HPA030670	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA030670
InParanoid	Q96BD0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96BD0
IntAct	Q96BD0	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96BD0*
InterPro	IPR002350	http://www.ebi.ac.uk/interpro/entry/IPR002350
InterPro	IPR004156	http://www.ebi.ac.uk/interpro/entry/IPR004156
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	28231	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=28231
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:28231	http://www.genome.jp/dbget-bin/www_bget?hsa:28231
KEGG_Orthology	KO:K14354	http://www.genome.jp/dbget-bin/www_bget?KO:K14354
MIM	612436	http://www.ncbi.nlm.nih.gov/omim/612436
OMA	GPNSAME	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GPNSAME
OrthoDB	EOG091G02FX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02FX
PANTHER	PTHR11388	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11388
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PROSITE	PS51465	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51465
PSORT	swissprot:SO4A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SO4A1_HUMAN
PSORT-B	swissprot:SO4A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SO4A1_HUMAN
PSORT2	swissprot:SO4A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SO4A1_HUMAN
Pfam	PF03137	http://pfam.xfam.org/family/PF03137
Pfam	PF07648	http://pfam.xfam.org/family/PF07648
PharmGKB	PA35838	http://www.pharmgkb.org/do/serve?objId=PA35838&objCls=Gene
Phobius	swissprot:SO4A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SO4A1_HUMAN
PhylomeDB	Q96BD0	http://phylomedb.org/?seqid=Q96BD0
ProteinModelPortal	Q96BD0	http://www.proteinmodelportal.org/query/uniprot/Q96BD0
PubMed	10873595	http://www.ncbi.nlm.nih.gov/pubmed/10873595
PubMed	11316767	http://www.ncbi.nlm.nih.gov/pubmed/11316767
PubMed	11780052	http://www.ncbi.nlm.nih.gov/pubmed/11780052
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
Reactome	R-HSA-879518	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-879518
RefSeq	NP_057438	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_057438
STRING	9606.ENSP00000217159	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000217159&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.60.1	http://www.tcdb.org/search/result.php?tc=2.A.60.1
TIGRFAMs	TIGR00805	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00805
UCSC	uc002ydb	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ydb&org=rat
UniGene	Hs.235782	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.235782
UniProtKB	SO4A1_HUMAN	http://www.uniprot.org/uniprot/SO4A1_HUMAN
UniProtKB-AC	Q96BD0	http://www.uniprot.org/uniprot/Q96BD0
charge	swissprot:SO4A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SO4A1_HUMAN
eggNOG	ENOG410XRSF	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRSF
eggNOG	KOG3626	http://eggnogapi.embl.de/nog_data/html/tree/KOG3626
epestfind	swissprot:SO4A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SO4A1_HUMAN
garnier	swissprot:SO4A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SO4A1_HUMAN
helixturnhelix	swissprot:SO4A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SO4A1_HUMAN
hmoment	swissprot:SO4A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SO4A1_HUMAN
iep	swissprot:SO4A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SO4A1_HUMAN
inforesidue	swissprot:SO4A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SO4A1_HUMAN
neXtProt	NX_Q96BD0	http://www.nextprot.org/db/entry/NX_Q96BD0
octanol	swissprot:SO4A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SO4A1_HUMAN
pepcoil	swissprot:SO4A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SO4A1_HUMAN
pepdigest	swissprot:SO4A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SO4A1_HUMAN
pepinfo	swissprot:SO4A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SO4A1_HUMAN
pepnet	swissprot:SO4A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SO4A1_HUMAN
pepstats	swissprot:SO4A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SO4A1_HUMAN
pepwheel	swissprot:SO4A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SO4A1_HUMAN
pepwindow	swissprot:SO4A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SO4A1_HUMAN
sigcleave	swissprot:SO4A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SO4A1_HUMAN
## Database	ID	URL or Descriptions
# AltName	IMA3_HUMAN	Importin alpha Q1
# AltName	IMA3_HUMAN	Karyopherin subunit alpha-4
# BioGrid	110038	83
# CAUTION	Was termed importin alpha-3. {ECO:0000305|PubMed	9395085}.
# ChiTaRS	KPNA4	human
# DOMAIN	IMA3_HUMAN	Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import. 
# DOMAIN	IMA3_HUMAN	The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS- containing proteins (By similarity). {ECO 0000250}. 
# DOMAIN	IMA3_HUMAN	The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity). {ECO 0000250}. 
# Ensembl	ENST00000334256	ENSP00000334373; ENSG00000186432
# ExpressionAtlas	O00629	baseline and differential
# FUNCTION	IMA3_HUMAN	Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. 
# GO_component	GO:0005643	nuclear pore; IBA:GO_Central.
# GO_component	GO:0005654	nucleoplasm; IBA:GO_Central.
# GO_component	GO:0005829	cytosol; IBA:GO_Central.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0008139	nuclear localization sequence binding; IBA:GO_Central.
# GO_function	GO:0008565	protein transporter activity; IBA:GO_Central.
# GO_process	GO:0006607	NLS-bearing protein import into nucleus; TAS:ProtInc.
# GO_process	GO:0019054	modulation by virus of host process; TAS:Reactome.
# GO_process	GO:0042542	response to hydrogen peroxide; IEA:Ensembl.
# GO_process	GO:0075733	intracellular transport of virus; TAS:Reactome.
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# Gene3D	1.25.10.10	-; 1.
# Genevisible	O00629	HS
# HGNC	HGNC:6397	KPNA4
# INTERACTION	IMA3_HUMAN	Q6ZMK1 CYHR1; NbExp=3; IntAct=EBI-396343, EBI-3908824; P04585 gag-pol (xeno); NbExp=4; IntAct=EBI-396343, EBI-9872653; P07910 HNRNPC; NbExp=5; IntAct=EBI-396343, EBI-357966; Q9NZL9 MAT2B; NbExp=3; IntAct=EBI-396343, EBI-10317491; Q9UKX7 NUP50; NbExp=5; IntAct=EBI-396343, EBI-2371082; Q9Y263 PLAA; NbExp=3; IntAct=EBI-396343, EBI-1994037; P46063 RECQL; NbExp=2; IntAct=EBI-396343, EBI-2823728; 
# IntAct	O00629	51
# InterPro	IPR000225	Armadillo
# InterPro	IPR002652	Importin-a_IBB
# InterPro	IPR011989	ARM-like
# InterPro	IPR016024	ARM-type_fold
# InterPro	IPR024931	Importing_su_alpha
# InterPro	IPR032413	Arm_3
# MIM	602970	gene
# Organism	IMA3_HUMAN	Homo sapiens (Human)
# PDB	4UAE	X-ray; 2.70 A; A=68-487
# PIR	JC5505	JC5505
# PIRSF	PIRSF005673	Importin_alpha
# PROSITE	PS50176	ARM_REPEAT; 3
# PROSITE	PS51214	IBB
# Pfam	PF00514	Arm; 8
# Pfam	PF01749	IBB
# Pfam	PF16186	Arm_3
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-1169408	ISG15 antiviral mechanism
# Reactome	R-HSA-168276	NS1 Mediated Effects on Host Pathways
# RecName	IMA3_HUMAN	Importin subunit alpha-3
# RefSeq	NP_002259	NM_002268.4
# SIMILARITY	Belongs to the importin alpha family. {ECO	0000305}. 
# SIMILARITY	Contains 1 IBB domain. {ECO:0000255|PROSITE- ProRule	PRU00561}. 
# SIMILARITY	Contains 10 ARM repeats. {ECO:0000255|PROSITE- ProRule	PRU00259}. 
# SMART	SM00185	ARM; 8
# SUBCELLULAR LOCATION	IMA3_HUMAN	Cytoplasm {ECO 0000250}. Nucleus {ECO 0000250}. 
# SUBUNIT	IMA3_HUMAN	Forms a complex with importin subunit beta-1. Interacts with SNAI1. Interacts with human adenovirus 5 E1A protein; this interaction allows E1A import into the host nucleus (PubMed 23864635). {ECO 0000269|PubMed 12610148, ECO 0000269|PubMed 21454664, ECO 0000269|PubMed 23864635}. 
# SUPFAM	SSF48371	SSF48371
# TCDB	1.I.1.1	the nuclear pore complex (npc) family
# TISSUE SPECIFICITY	IMA3_HUMAN	Highly expressed in testis, ovary, small intestine, heart, skeletal muscle, lung and pancreas, but barely detectable in kidney, thymus, colon and peripheral blood leukocytes. 
# UCSC	uc003fdn	human
# eggNOG	COG5064	LUCA
# eggNOG	KOG0166	Eukaryota
BLAST	swissprot:IMA3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:IMA3_HUMAN
BioCyc	ZFISH:ENSG00000144975-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000144975-MONOMER
COXPRESdb	3840	http://coxpresdb.jp/data/gene/3840.shtml
CleanEx	HS_KPNA4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KPNA4
DIP	DIP-32982N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-32982N
DOI	10.1006/bbrc.1997.6535	http://dx.doi.org/10.1006/bbrc.1997.6535
DOI	10.1016/S0014-5793(97)01265-9	http://dx.doi.org/10.1016/S0014-5793(97)01265-9
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1074/jbc.M110.213579	http://dx.doi.org/10.1074/jbc.M110.213579
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1128/JVI.00786-13	http://dx.doi.org/10.1128/JVI.00786-13
DOI	10.1128/JVI.77.6.3734-3748.2003	http://dx.doi.org/10.1128/JVI.77.6.3734-3748.2003
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AB002533	http://www.ebi.ac.uk/ena/data/view/AB002533
EMBL	AK291041	http://www.ebi.ac.uk/ena/data/view/AK291041
EMBL	BC028691	http://www.ebi.ac.uk/ena/data/view/BC028691
EMBL	BC034493	http://www.ebi.ac.uk/ena/data/view/BC034493
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
EMBL	U93240	http://www.ebi.ac.uk/ena/data/view/U93240
EMBL	Y12393	http://www.ebi.ac.uk/ena/data/view/Y12393
Ensembl	ENST00000334256	http://www.ensembl.org/id/ENST00000334256
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005643	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005643
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0008139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008139
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0006607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006607
GO_process	GO:0019054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019054
GO_process	GO:0042542	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042542
GO_process	GO:0075733	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0075733
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
GeneCards	KPNA4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KPNA4
GeneID	3840	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3840
GeneTree	ENSGT00760000119094	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119094
HGNC	HGNC:6397	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6397
HOGENOM	HOG000167616	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000167616&db=HOGENOM6
HOVERGEN	HBG001846	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG001846&db=HOVERGEN
HPA	CAB034336	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB034336
HPA	HPA043154	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA043154
HPA	HPA045500	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA045500
InParanoid	O00629	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O00629
IntAct	O00629	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O00629*
InterPro	IPR000225	http://www.ebi.ac.uk/interpro/entry/IPR000225
InterPro	IPR002652	http://www.ebi.ac.uk/interpro/entry/IPR002652
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
InterPro	IPR024931	http://www.ebi.ac.uk/interpro/entry/IPR024931
InterPro	IPR032413	http://www.ebi.ac.uk/interpro/entry/IPR032413
Jabion	3840	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3840
KEGG_Gene	hsa:3840	http://www.genome.jp/dbget-bin/www_bget?hsa:3840
MIM	602970	http://www.ncbi.nlm.nih.gov/omim/602970
MINT	MINT-5003750	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5003750
OMA	TMRRQRT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TMRRQRT
OrthoDB	EOG091G095Z	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G095Z
PDB	4UAE	http://www.ebi.ac.uk/pdbe-srv/view/entry/4UAE
PDBsum	4UAE	http://www.ebi.ac.uk/pdbsum/4UAE
PROSITE	PS50176	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50176
PROSITE	PS51214	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51214
PSORT	swissprot:IMA3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:IMA3_HUMAN
PSORT-B	swissprot:IMA3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:IMA3_HUMAN
PSORT2	swissprot:IMA3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:IMA3_HUMAN
Pfam	PF00514	http://pfam.xfam.org/family/PF00514
Pfam	PF01749	http://pfam.xfam.org/family/PF01749
Pfam	PF16186	http://pfam.xfam.org/family/PF16186
PharmGKB	PA30188	http://www.pharmgkb.org/do/serve?objId=PA30188&objCls=Gene
Phobius	swissprot:IMA3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:IMA3_HUMAN
PhylomeDB	O00629	http://phylomedb.org/?seqid=O00629
ProteinModelPortal	O00629	http://www.proteinmodelportal.org/query/uniprot/O00629
PubMed	12610148	http://www.ncbi.nlm.nih.gov/pubmed/12610148
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21454664	http://www.ncbi.nlm.nih.gov/pubmed/21454664
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	23864635	http://www.ncbi.nlm.nih.gov/pubmed/23864635
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	9168958	http://www.ncbi.nlm.nih.gov/pubmed/9168958
PubMed	9395085	http://www.ncbi.nlm.nih.gov/pubmed/9395085
Reactome	R-HSA-1169408	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1169408
Reactome	R-HSA-168276	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-168276
RefSeq	NP_002259	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002259
SMART	SM00185	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00185
SMR	O00629	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O00629
STRING	9606.ENSP00000334373	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000334373&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
TCDB	1.I.1.1	http://www.tcdb.org/search/result.php?tc=1.I.1.1
UCSC	uc003fdn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003fdn&org=rat
UniGene	Hs.467866	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.467866
UniProtKB	IMA3_HUMAN	http://www.uniprot.org/uniprot/IMA3_HUMAN
UniProtKB-AC	O00629	http://www.uniprot.org/uniprot/O00629
charge	swissprot:IMA3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:IMA3_HUMAN
eggNOG	COG5064	http://eggnogapi.embl.de/nog_data/html/tree/COG5064
eggNOG	KOG0166	http://eggnogapi.embl.de/nog_data/html/tree/KOG0166
epestfind	swissprot:IMA3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:IMA3_HUMAN
garnier	swissprot:IMA3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:IMA3_HUMAN
helixturnhelix	swissprot:IMA3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:IMA3_HUMAN
hmoment	swissprot:IMA3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:IMA3_HUMAN
iep	swissprot:IMA3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:IMA3_HUMAN
inforesidue	swissprot:IMA3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:IMA3_HUMAN
neXtProt	NX_O00629	http://www.nextprot.org/db/entry/NX_O00629
octanol	swissprot:IMA3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:IMA3_HUMAN
pepcoil	swissprot:IMA3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:IMA3_HUMAN
pepdigest	swissprot:IMA3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:IMA3_HUMAN
pepinfo	swissprot:IMA3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:IMA3_HUMAN
pepnet	swissprot:IMA3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:IMA3_HUMAN
pepstats	swissprot:IMA3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:IMA3_HUMAN
pepwheel	swissprot:IMA3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:IMA3_HUMAN
pepwindow	swissprot:IMA3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:IMA3_HUMAN
sigcleave	swissprot:IMA3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:IMA3_HUMAN
## Database	ID	URL or Descriptions
# AltName	S38A1_HUMAN	Amino acid transporter A1
# AltName	S38A1_HUMAN	N-system amino acid transporter 2
# AltName	S38A1_HUMAN	Solute carrier family 38 member 1
# AltName	S38A1_HUMAN	System A amino acid transporter 1
# AltName	S38A1_HUMAN	System N amino acid transporter 1
# BIOPHYSICOCHEMICAL PROPERTIES	Kinetic parameters: KM=890 uM for 2-methylamino-isobutyric acid (MeAIB) (at pH 8.5) {ECO	0000269|PubMed:10891391}; 
# BioGrid	123509	6
# ChiTaRS	SLC38A1	human
# ENZYME REGULATION	Inhibited by potassium, choline ions and 2- methylamino-isobutyric acid (MeAIB) (By similarity). Inhibited by lithium and N-methyl-D-glucamine. {ECO:0000250, ECO	0000269|PubMed:10891391}. 
# Ensembl	ENST00000398637	ENSP00000381634; ENSG00000111371
# Ensembl	ENST00000439706	ENSP00000398142; ENSG00000111371
# Ensembl	ENST00000546893	ENSP00000447853; ENSG00000111371
# Ensembl	ENST00000549049	ENSP00000449607; ENSG00000111371
# ExpressionAtlas	Q9H2H9	baseline and differential
# FUNCTION	S38A1_HUMAN	Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1 1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA. {ECO 0000269|PubMed 10891391}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005290	L-histidine transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015175	neutral amino acid transmembrane transporter activity; NAS:UniProtKB.
# GO_function	GO:0015179	L-amino acid transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015182	L-asparagine transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015186	L-glutamine transmembrane transporter activity; IBA:GO_Central.
# GO_function	S38A1_HUMAN	GO 0005283 sodium amino acid symporter activity; NAS UniProtKB.
# GO_process	GO:0001504	neurotransmitter uptake; TAS:Reactome.
# GO_process	GO:0006865	amino acid transport; TAS:Reactome.
# GO_process	GO:0006867	asparagine transport; IBA:GO_Central.
# GO_process	GO:0006868	glutamine transport; IBA:GO_Central.
# GO_process	GO:0015804	neutral amino acid transport; NAS:UniProtKB.
# GO_process	GO:0015817	histidine transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q9H2H9	HS
# HGNC	HGNC:13447	SLC38A1
# INDUCTION	S38A1_HUMAN	Down-regulated by bacterial lipopolysaccharides (LPS) in glial cells. Down-regulated upon hypoxia. {ECO 0000269|PubMed 12388062, ECO 0000269|PubMed 16583402}. 
# INTERACTION	S38A1_HUMAN	Q969F0 FATE1; NbExp=5; IntAct=EBI-9978441, EBI-743099; 
# IntAct	Q9H2H9	55
# InterPro	IPR013057	AA_transpt_TM
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04724	Glutamatergic synapse
# KEGG_Pathway	ko04727	GABAergic synapse
# MIM	608490	gene
# Organism	S38A1_HUMAN	Homo sapiens (Human)
# PIR	JC7328	JC7328
# Pfam	PF01490	Aa_trans
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-210455	Astrocytic Glutamate-Glutamine Uptake And Metabolism
# Reactome	R-HSA-352230	Amino acid transport across the plasma membrane
# RecName	S38A1_HUMAN	Sodium-coupled neutral amino acid transporter 1
# RefSeq	NP_001070952	NM_001077484.1
# RefSeq	NP_001265316	NM_001278387.1
# RefSeq	NP_001265317	NM_001278388.1
# RefSeq	NP_001265318	NM_001278389.1
# RefSeq	NP_109599	NM_030674.3
# SEQUENCE CAUTION	Sequence=AAG44546.1; Type=Frameshift; Positions=443; Evidence={ECO:0000305}; Sequence=BAC11186.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the amino acid/polyamine transporter 2 family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S38A1_HUMAN	Cell membrane {ECO 0000269|PubMed 15054072}; Multi-pass membrane protein {ECO 0000269|PubMed 15054072}. Note=Restricted to the somatodendritic compartment of neurons. Found in the cellular processes of neurons in the developing brain (By similarity). {ECO 0000250}. 
# TCDB	2.A.18.6.14	the amino acid/auxin permease (aaap) family
# TISSUE SPECIFICITY	S38A1_HUMAN	Expressed in the cerebral cortex by pyramidal and GABAergic neurons, astrocytes and other non-neuronal cells (at protein level). Expressed in placenta, heart, lung, skeletal muscle, spleen, stomach and testis. {ECO 0000269|PubMed 10891391, ECO 0000269|PubMed 12388062, ECO 0000269|PubMed 15054072, ECO 0000269|PubMed 16148032}. 
# UCSC	uc001rpb	human
# eggNOG	COG0814	LUCA
# eggNOG	KOG1305	Eukaryota
BLAST	swissprot:S38A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S38A1_HUMAN
COXPRESdb	81539	http://coxpresdb.jp/data/gene/81539.shtml
CleanEx	HS_NAT2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_NAT2
CleanEx	HS_SAT1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SAT1
CleanEx	HS_SLC38A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC38A1
DOI	10.1002/jnr.20855	http://dx.doi.org/10.1002/jnr.20855
DOI	10.1006/bbrc.2000.3061	http://dx.doi.org/10.1006/bbrc.2000.3061
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1093/cercor/bhh018	http://dx.doi.org/10.1093/cercor/bhh018
DOI	10.1093/dnares/12.2.117	http://dx.doi.org/10.1093/dnares/12.2.117
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1152/ajpcell.00253.2002	http://dx.doi.org/10.1152/ajpcell.00253.2002
DOI	10.1152/ajpcell.00258.2005	http://dx.doi.org/10.1152/ajpcell.00258.2005
EMBL	AF247166	http://www.ebi.ac.uk/ena/data/view/AF247166
EMBL	AF271070	http://www.ebi.ac.uk/ena/data/view/AF271070
EMBL	AK027825	http://www.ebi.ac.uk/ena/data/view/AK027825
EMBL	AK074758	http://www.ebi.ac.uk/ena/data/view/AK074758
EMBL	AK074949	http://www.ebi.ac.uk/ena/data/view/AK074949
EMBL	BC010620	http://www.ebi.ac.uk/ena/data/view/BC010620
EMBL	CH471111	http://www.ebi.ac.uk/ena/data/view/CH471111
Ensembl	ENST00000398637	http://www.ensembl.org/id/ENST00000398637
Ensembl	ENST00000439706	http://www.ensembl.org/id/ENST00000439706
Ensembl	ENST00000546893	http://www.ensembl.org/id/ENST00000546893
Ensembl	ENST00000549049	http://www.ensembl.org/id/ENST00000549049
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005283
GO_function	GO:0005290	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005290
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_function	GO:0015175	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015175
GO_function	GO:0015179	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015179
GO_function	GO:0015182	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015182
GO_function	GO:0015186	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015186
GO_process	GO:0001504	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001504
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GO_process	GO:0006867	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006867
GO_process	GO:0006868	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006868
GO_process	GO:0015804	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015804
GO_process	GO:0015817	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015817
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC38A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC38A1
GeneID	81539	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81539
GeneTree	ENSGT00760000119147	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119147
HGNC	HGNC:13447	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13447
HOGENOM	HOG000013088	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000013088&db=HOGENOM6
HOVERGEN	HBG059571	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG059571&db=HOVERGEN
HPA	HPA052272	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA052272
InParanoid	Q9H2H9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9H2H9
IntAct	Q9H2H9	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9H2H9*
InterPro	IPR013057	http://www.ebi.ac.uk/interpro/entry/IPR013057
Jabion	81539	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=81539
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:81539	http://www.genome.jp/dbget-bin/www_bget?hsa:81539
KEGG_Orthology	KO:K14990	http://www.genome.jp/dbget-bin/www_bget?KO:K14990
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
MIM	608490	http://www.ncbi.nlm.nih.gov/omim/608490
PSORT	swissprot:S38A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S38A1_HUMAN
PSORT-B	swissprot:S38A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S38A1_HUMAN
PSORT2	swissprot:S38A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S38A1_HUMAN
Pfam	PF01490	http://pfam.xfam.org/family/PF01490
PharmGKB	PA37772	http://www.pharmgkb.org/do/serve?objId=PA37772&objCls=Gene
Phobius	swissprot:S38A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S38A1_HUMAN
PhylomeDB	Q9H2H9	http://phylomedb.org/?seqid=Q9H2H9
ProteinModelPortal	Q9H2H9	http://www.proteinmodelportal.org/query/uniprot/Q9H2H9
PubMed	10891391	http://www.ncbi.nlm.nih.gov/pubmed/10891391
PubMed	12388062	http://www.ncbi.nlm.nih.gov/pubmed/12388062
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15054072	http://www.ncbi.nlm.nih.gov/pubmed/15054072
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16148032	http://www.ncbi.nlm.nih.gov/pubmed/16148032
PubMed	16303743	http://www.ncbi.nlm.nih.gov/pubmed/16303743
PubMed	16583402	http://www.ncbi.nlm.nih.gov/pubmed/16583402
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
Reactome	R-HSA-210455	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-210455
Reactome	R-HSA-352230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-352230
RefSeq	NP_001070952	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001070952
RefSeq	NP_001265316	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001265316
RefSeq	NP_001265317	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001265317
RefSeq	NP_001265318	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001265318
RefSeq	NP_109599	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_109599
STRING	9606.ENSP00000381634	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000381634&targetmode=cogs
TCDB	2.A.18.6.14	http://www.tcdb.org/search/result.php?tc=2.A.18.6.14
UCSC	uc001rpb	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001rpb&org=rat
UniGene	Hs.533770	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.533770
UniProtKB	S38A1_HUMAN	http://www.uniprot.org/uniprot/S38A1_HUMAN
UniProtKB-AC	Q9H2H9	http://www.uniprot.org/uniprot/Q9H2H9
charge	swissprot:S38A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S38A1_HUMAN
eggNOG	COG0814	http://eggnogapi.embl.de/nog_data/html/tree/COG0814
eggNOG	KOG1305	http://eggnogapi.embl.de/nog_data/html/tree/KOG1305
epestfind	swissprot:S38A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S38A1_HUMAN
garnier	swissprot:S38A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S38A1_HUMAN
helixturnhelix	swissprot:S38A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S38A1_HUMAN
hmoment	swissprot:S38A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S38A1_HUMAN
iep	swissprot:S38A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S38A1_HUMAN
inforesidue	swissprot:S38A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S38A1_HUMAN
neXtProt	NX_Q9H2H9	http://www.nextprot.org/db/entry/NX_Q9H2H9
octanol	swissprot:S38A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S38A1_HUMAN
pepcoil	swissprot:S38A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S38A1_HUMAN
pepdigest	swissprot:S38A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S38A1_HUMAN
pepinfo	swissprot:S38A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S38A1_HUMAN
pepnet	swissprot:S38A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S38A1_HUMAN
pepstats	swissprot:S38A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S38A1_HUMAN
pepwheel	swissprot:S38A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S38A1_HUMAN
pepwindow	swissprot:S38A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S38A1_HUMAN
sigcleave	swissprot:S38A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S38A1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SC6A8_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=CRT1; IsoId=P48029-1; Sequence=Displayed; Name=2; Synonyms=CRT2, SLC6A8B; IsoId=P48029-2; Sequence=VSP_043917, VSP_043918, VSP_043919, VSP_043920; Name=3; Synonyms=SLC6A8C; IsoId=P48029-3; Sequence=VSP_043916; Name=4; IsoId=P48029-4; Sequence=VSP_046316; Note=No experimental confirmation available.; 
# AltName	SC6A8_HUMAN	Solute carrier family 6 member 8
# BioGrid	112426	10
# CCDS	CCDS14726	-. [P48029-1]
# CCDS	CCDS48190	-. [P48029-4]
# DISEASE	SC6A8_HUMAN	Cerebral creatine deficiency syndrome 1 (CCDS1) [MIM 300352]  An X-linked disorder of creatine transport characterized by mental retardation, severe speech delay, behavioral abnormalities, and seizures. Carrier females may show mild neuropsychologic impairment. {ECO 0000269|PubMed 11898126, ECO 0000269|PubMed 12210795, ECO 0000269|PubMed 15154114, ECO 0000269|PubMed 17101918, ECO 0000269|PubMed 17465020, ECO 0000269|PubMed 23660394, ECO 0000269|PubMed 24123876, ECO 0000269|PubMed 25861866}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00148	Creatine
# Ensembl	ENST00000253122	ENSP00000253122; ENSG00000130821. [P48029-1]
# Ensembl	ENST00000430077	ENSP00000403041; ENSG00000130821. [P48029-4]
# ExpressionAtlas	P48029	baseline and differential
# FUNCTION	SC6A8_HUMAN	Required for the uptake of creatine in muscles and brain. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_function	GO:0005308	creatine transmembrane transporter activity; NAS:UniProtKB.
# GO_function	SC6A8_HUMAN	GO 0005309 creatine sodium symporter activity; TAS Reactome.
# GO_function	SC6A8_HUMAN	GO 0005328 neurotransmitter sodium symporter activity; IEA InterPro.
# GO_process	GO:0006600	creatine metabolic process; TAS:Reactome.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006936	muscle contraction; TAS:ProtInc.
# GO_process	GO:0015881	creatine transport; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006520	cellular amino acid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Genevisible	P48029	HS
# HGNC	HGNC:11055	SLC6A8
# IntAct	P48029	4
# InterPro	IPR000175	Na/ntran_symport
# InterPro	IPR002984	Na/ntran_symport_creatine
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00480	[Congenital disorder; Mental retardation] Non-syndromic X-linked mental retardation
# KEGG_Disease	H00577	[Congenital disorder; Mental retardation; Epilepsy] Rolandic epilepsy
# KEGG_Disease	H00849	[Inherited metabolic disease; Mental retardation] X-linked creatine deficiency syndrome (XL-CDS)
# MIM	300036	gene
# MIM	300352	phenotype
# Organism	SC6A8_HUMAN	Homo sapiens (Human)
# Orphanet	52503	X-linked creatine transporter deficiency
# PANTHER	PTHR11616	PTHR11616
# PIR	G02095	G02095
# PIR	JC2386	JC2386
# PRINTS	PR00176	NANEUSMPORT
# PRINTS	PR01199	CRTTRANSPORT
# PROSITE	PS00610	NA_NEUROTRAN_SYMP_1
# PROSITE	PS00754	NA_NEUROTRAN_SYMP_2
# PROSITE	PS50267	NA_NEUROTRAN_SYMP_3
# Pfam	PF00209	SNF
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-71288	Creatine metabolism
# RecName	SC6A8_HUMAN	Sodium- and chloride-dependent creatine transporter 1
# RefSeq	NP_001136277	NM_001142805.1
# RefSeq	NP_001136278	NM_001142806.1. [P48029-4]
# RefSeq	NP_005620	NM_005629.3. [P48029-1]
# SIMILARITY	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A8 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	SC6A8_HUMAN	Membrane; Multi-pass membrane protein. 
# TCDB	2.A.22.3.11:the neurotransmitter	sodium symporter (nss) family
# TISSUE SPECIFICITY	SC6A8_HUMAN	Predominantly expressed in skeletal muscle and kidney. Also found in brain, heart, colon, testis and prostate. {ECO 0000269|PubMed 7945388, ECO 0000269|PubMed 7953292}. 
# UCSC	uc011myx	human. [P48029-1]
# eggNOG	COG0733	LUCA
# eggNOG	KOG3659	Eukaryota
BLAST	swissprot:SC6A8_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SC6A8_HUMAN
BioCyc	ZFISH:ENSG00000130821-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000130821-MONOMER
COXPRESdb	6535	http://coxpresdb.jp/data/gene/6535.shtml
CleanEx	HS_SLC6A8	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC6A8
DOI	10.1002/ana.10246	http://dx.doi.org/10.1002/ana.10246
DOI	10.1002/humu.20532	http://dx.doi.org/10.1002/humu.20532
DOI	10.1006/bbrc.1994.2475	http://dx.doi.org/10.1006/bbrc.1994.2475
DOI	10.1006/geno.1996.0373	http://dx.doi.org/10.1006/geno.1996.0373
DOI	10.1016/0378-1119(95)00104-E	http://dx.doi.org/10.1016/0378-1119(95)00104-E
DOI	10.1016/j.gene.2008.04.003	http://dx.doi.org/10.1016/j.gene.2008.04.003
DOI	10.1016/j.gene.2015.04.011	http://dx.doi.org/10.1016/j.gene.2015.04.011
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1016/j.ymgme.2013.04.006	http://dx.doi.org/10.1016/j.ymgme.2013.04.006
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/tp.2012.102	http://dx.doi.org/10.1038/tp.2012.102
DOI	10.1086/340092	http://dx.doi.org/10.1086/340092
DOI	10.1086/422102	http://dx.doi.org/10.1086/422102
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1136/jmedgenet-2013-101644	http://dx.doi.org/10.1136/jmedgenet-2013-101644
DOI	10.1212/01.wnl.0000239153.39710.81	http://dx.doi.org/10.1212/01.wnl.0000239153.39710.81
DrugBank	DB00148	http://www.drugbank.ca/drugs/DB00148
EMBL	AK295495	http://www.ebi.ac.uk/ena/data/view/AK295495
EMBL	BC012355	http://www.ebi.ac.uk/ena/data/view/BC012355
EMBL	BC081558	http://www.ebi.ac.uk/ena/data/view/BC081558
EMBL	EU280316	http://www.ebi.ac.uk/ena/data/view/EU280316
EMBL	L31409	http://www.ebi.ac.uk/ena/data/view/L31409
EMBL	S74039	http://www.ebi.ac.uk/ena/data/view/S74039
EMBL	U17986	http://www.ebi.ac.uk/ena/data/view/U17986
EMBL	U36341	http://www.ebi.ac.uk/ena/data/view/U36341
EMBL	U52111	http://www.ebi.ac.uk/ena/data/view/U52111
EMBL	Z66539	http://www.ebi.ac.uk/ena/data/view/Z66539
Ensembl	ENST00000253122	http://www.ensembl.org/id/ENST00000253122
Ensembl	ENST00000430077	http://www.ensembl.org/id/ENST00000430077
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005308	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005308
GO_function	GO:0005309	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005309
GO_function	GO:0005328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005328
GO_process	GO:0006600	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006600
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006936	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006936
GO_process	GO:0015881	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015881
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	SLC6A8	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC6A8
GeneID	6535	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6535
GeneTree	ENSGT00760000118857	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118857
H-InvDB	HIX0038627	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0038627
HGNC	HGNC:11055	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11055
HOGENOM	HOG000203877	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000203877&db=HOGENOM6
HOVERGEN	HBG071421	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG071421&db=HOVERGEN
HPA	CAB004399	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB004399
InParanoid	P48029	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P48029
IntAct	P48029	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P48029*
InterPro	IPR000175	http://www.ebi.ac.uk/interpro/entry/IPR000175
InterPro	IPR002984	http://www.ebi.ac.uk/interpro/entry/IPR002984
Jabion	6535	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6535
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00480	http://www.genome.jp/dbget-bin/www_bget?H00480
KEGG_Disease	H00577	http://www.genome.jp/dbget-bin/www_bget?H00577
KEGG_Disease	H00849	http://www.genome.jp/dbget-bin/www_bget?H00849
KEGG_Gene	hsa:6535	http://www.genome.jp/dbget-bin/www_bget?hsa:6535
KEGG_Orthology	KO:K05039	http://www.genome.jp/dbget-bin/www_bget?KO:K05039
MIM	300036	http://www.ncbi.nlm.nih.gov/omim/300036
MIM	300352	http://www.ncbi.nlm.nih.gov/omim/300352
OMA	VPPRETW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VPPRETW
Orphanet	52503	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=52503
OrthoDB	EOG091G08PX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08PX
PANTHER	PTHR11616	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11616
PRINTS	PR00176	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00176
PRINTS	PR01199	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01199
PROSITE	PS00610	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00610
PROSITE	PS00754	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00754
PROSITE	PS50267	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50267
PSORT	swissprot:SC6A8_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SC6A8_HUMAN
PSORT-B	swissprot:SC6A8_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SC6A8_HUMAN
PSORT2	swissprot:SC6A8_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SC6A8_HUMAN
Pfam	PF00209	http://pfam.xfam.org/family/PF00209
PharmGKB	PA35915	http://www.pharmgkb.org/do/serve?objId=PA35915&objCls=Gene
Phobius	swissprot:SC6A8_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SC6A8_HUMAN
PhylomeDB	P48029	http://phylomedb.org/?seqid=P48029
ProteinModelPortal	P48029	http://www.proteinmodelportal.org/query/uniprot/P48029
PubMed	11898126	http://www.ncbi.nlm.nih.gov/pubmed/11898126
PubMed	12210795	http://www.ncbi.nlm.nih.gov/pubmed/12210795
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15154114	http://www.ncbi.nlm.nih.gov/pubmed/15154114
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	17101918	http://www.ncbi.nlm.nih.gov/pubmed/17101918
PubMed	17465020	http://www.ncbi.nlm.nih.gov/pubmed/17465020
PubMed	18515020	http://www.ncbi.nlm.nih.gov/pubmed/18515020
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	23092983	http://www.ncbi.nlm.nih.gov/pubmed/23092983
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	23660394	http://www.ncbi.nlm.nih.gov/pubmed/23660394
PubMed	24123876	http://www.ncbi.nlm.nih.gov/pubmed/24123876
PubMed	25861866	http://www.ncbi.nlm.nih.gov/pubmed/25861866
PubMed	7622069	http://www.ncbi.nlm.nih.gov/pubmed/7622069
PubMed	7945388	http://www.ncbi.nlm.nih.gov/pubmed/7945388
PubMed	7953292	http://www.ncbi.nlm.nih.gov/pubmed/7953292
PubMed	8661155	http://www.ncbi.nlm.nih.gov/pubmed/8661155
Reactome	R-HSA-71288	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-71288
RefSeq	NP_001136277	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001136277
RefSeq	NP_001136278	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001136278
RefSeq	NP_005620	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005620
STRING	9606.ENSP00000253122	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000253122&targetmode=cogs
TCDB	2.A.22.3.11	http://www.tcdb.org/search/result.php?tc=2.A.22.3.11
UCSC	uc011myx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc011myx&org=rat
UniGene	Hs.540696	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.540696
UniProtKB	SC6A8_HUMAN	http://www.uniprot.org/uniprot/SC6A8_HUMAN
UniProtKB-AC	P48029	http://www.uniprot.org/uniprot/P48029
charge	swissprot:SC6A8_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SC6A8_HUMAN
eggNOG	COG0733	http://eggnogapi.embl.de/nog_data/html/tree/COG0733
eggNOG	KOG3659	http://eggnogapi.embl.de/nog_data/html/tree/KOG3659
epestfind	swissprot:SC6A8_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SC6A8_HUMAN
garnier	swissprot:SC6A8_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SC6A8_HUMAN
helixturnhelix	swissprot:SC6A8_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SC6A8_HUMAN
hmoment	swissprot:SC6A8_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SC6A8_HUMAN
iep	swissprot:SC6A8_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SC6A8_HUMAN
inforesidue	swissprot:SC6A8_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SC6A8_HUMAN
neXtProt	NX_P48029	http://www.nextprot.org/db/entry/NX_P48029
octanol	swissprot:SC6A8_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SC6A8_HUMAN
pepcoil	swissprot:SC6A8_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SC6A8_HUMAN
pepdigest	swissprot:SC6A8_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SC6A8_HUMAN
pepinfo	swissprot:SC6A8_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SC6A8_HUMAN
pepnet	swissprot:SC6A8_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SC6A8_HUMAN
pepstats	swissprot:SC6A8_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SC6A8_HUMAN
pepwheel	swissprot:SC6A8_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SC6A8_HUMAN
pepwindow	swissprot:SC6A8_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SC6A8_HUMAN
sigcleave	swissprot:SC6A8_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SC6A8_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNH6_HUMAN	Event=Alternative splicing; Named isoforms=3; Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=Q9H252-1; Sequence=Displayed; Name=2; IsoId=Q9H252-2; Sequence=VSP_000977, VSP_000978; Name=3; IsoId=Q9H252-3; Sequence=VSP_000979, VSP_000980; 
# AltName	KCNH6_HUMAN	Ether-a-go-go-related gene potassium channel 2
# AltName	KCNH6_HUMAN	Voltage-gated potassium channel subunit Kv11.2
# CCDS	CCDS11638	-. [Q9H252-1]
# CCDS	CCDS11639	-. [Q9H252-2]
# DOMAIN	KCNH6_HUMAN	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. 
# DrugBank	DB00308	Ibutilide
# DrugBank	DB00457	Prazosin
# DrugBank	DB00590	Doxazosin
# DrugBank	DB01110	Miconazole
# DrugBank	DB01162	Terazosin
# Ensembl	ENST00000456941	ENSP00000396900; ENSG00000173826. [Q9H252-2]
# Ensembl	ENST00000580652	ENSP00000464672; ENSG00000173826. [Q9H252-3]
# Ensembl	ENST00000581784	ENSP00000463830; ENSG00000173826. [Q9H252-2]
# Ensembl	ENST00000583023	ENSP00000463533; ENSG00000173826. [Q9H252-1]
# ExpressionAtlas	Q9H252	baseline and differential
# FUNCTION	KCNH6_HUMAN	Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current (By similarity). Channel properties may be modulated by cAMP and subunit assembly. {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IBA:GO_Central.
# GO_process	GO:0042391	regulation of membrane potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# Gene3D	2.60.120.10	-; 2.
# Genevisible	Q9H252	HS
# HGNC	HGNC:18862	KCNH6
# InterPro	IPR000014	PAS
# InterPro	IPR000595	cNMP-bd_dom
# InterPro	IPR003938	K_chnl_volt-dep_EAG/ELK/ERG
# InterPro	IPR003967	K_chnl_volt-dep_ERG
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR014710	RmlC-like_jellyroll
# InterPro	IPR018490	cNMP-bd-like
# InterPro	IPR030172	KCNH6
# KEGG_Brite	ko04040	Ion channels
# MIM	608168	gene
# Organism	KCNH6_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10217:SF468	PTHR10217:SF468
# PRINTS	PR01463	EAGCHANLFMLY
# PRINTS	PR01470	ERGCHANNEL
# PROSITE	PS50042	CNMP_BINDING_3
# Pfam	PF00027	cNMP_binding
# Pfam	PF00520	Ion_trans
# Pfam	PF13426	PAS_9
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# RecName	KCNH6_HUMAN	Potassium voltage-gated channel subfamily H member 6
# RefSeq	NP_001265848	NM_001278919.1
# RefSeq	NP_001265849	NM_001278920.1
# RefSeq	NP_110406	NM_030779.3. [Q9H252-1]
# RefSeq	NP_775115	NM_173092.2. [Q9H252-2]
# RefSeq	XP_011523612	XM_011525310.2. [Q9H252-2]
# RefSeq	XP_016880664	XM_017025175.1. [Q9H252-1]
# SIMILARITY	Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.2/KCNH6 sub-subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 PAC (PAS-associated C-terminal) domain. {ECO	0000305}. 
# SIMILARITY	Contains 1 PAS (PER-ARNT-SIM) domain. {ECO	0000305}.
# SIMILARITY	Contains 1 cyclic nucleotide-binding domain. {ECO:0000255|PROSITE-ProRule	PRU00060}. 
# SMART	SM00100	cNMP
# SUBCELLULAR LOCATION	KCNH6_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimers with KCNH2/ERG1 and KCNH7/ERG3 (By similarity). {ECO	0000250}. 
# SUPFAM	SSF51206	SSF51206
# SUPFAM	SSF55785	SSF55785
# TISSUE SPECIFICITY	Expressed in prolactin-secreting adenomas. {ECO:0000269|PubMed	12634931}. 
# UCSC	uc002jax	human. [Q9H252-1]
# eggNOG	ENOG410XPSE	LUCA
# eggNOG	KOG0498	Eukaryota
BLAST	swissprot:KCNH6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNH6_HUMAN
BioCyc	ZFISH:ENSG00000173826-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000173826-MONOMER
COXPRESdb	81033	http://coxpresdb.jp/data/gene/81033.shtml
CleanEx	HS_KCNH6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNH6
DOI	10.1007/s00424-002-0980-0	http://dx.doi.org/10.1007/s00424-002-0980-0
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/mcp.M800504-MCP200	http://dx.doi.org/10.1074/mcp.M800504-MCP200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00308	http://www.drugbank.ca/drugs/DB00308
DrugBank	DB00457	http://www.drugbank.ca/drugs/DB00457
DrugBank	DB00590	http://www.drugbank.ca/drugs/DB00590
DrugBank	DB01110	http://www.drugbank.ca/drugs/DB01110
DrugBank	DB01162	http://www.drugbank.ca/drugs/DB01162
EMBL	AF311913	http://www.ebi.ac.uk/ena/data/view/AF311913
EMBL	AK090969	http://www.ebi.ac.uk/ena/data/view/AK090969
EMBL	AK091877	http://www.ebi.ac.uk/ena/data/view/AK091877
EMBL	BC006334	http://www.ebi.ac.uk/ena/data/view/BC006334
Ensembl	ENST00000456941	http://www.ensembl.org/id/ENST00000456941
Ensembl	ENST00000580652	http://www.ensembl.org/id/ENST00000580652
Ensembl	ENST00000581784	http://www.ensembl.org/id/ENST00000581784
Ensembl	ENST00000583023	http://www.ensembl.org/id/ENST00000583023
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	2.60.120.10	http://www.cathdb.info/version/latest/superfamily/2.60.120.10
GeneCards	KCNH6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNH6
GeneID	81033	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81033
GeneTree	ENSGT00760000118772	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118772
HGNC	HGNC:18862	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18862
HOGENOM	HOG000230793	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230793&db=HOGENOM6
HOVERGEN	HBG052232	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052232&db=HOVERGEN
HPA	CAB022674	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB022674
InParanoid	Q9H252	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9H252
InterPro	IPR000014	http://www.ebi.ac.uk/interpro/entry/IPR000014
InterPro	IPR000595	http://www.ebi.ac.uk/interpro/entry/IPR000595
InterPro	IPR003938	http://www.ebi.ac.uk/interpro/entry/IPR003938
InterPro	IPR003967	http://www.ebi.ac.uk/interpro/entry/IPR003967
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR014710	http://www.ebi.ac.uk/interpro/entry/IPR014710
InterPro	IPR018490	http://www.ebi.ac.uk/interpro/entry/IPR018490
InterPro	IPR030172	http://www.ebi.ac.uk/interpro/entry/IPR030172
Jabion	81033	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=81033
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:81033	http://www.genome.jp/dbget-bin/www_bget?hsa:81033
KEGG_Orthology	KO:K04909	http://www.genome.jp/dbget-bin/www_bget?KO:K04909
MIM	608168	http://www.ncbi.nlm.nih.gov/omim/608168
OMA	VSHPRRI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VSHPRRI
OrthoDB	EOG091G024C	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G024C
PANTHER	PTHR10217:SF468	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10217:SF468
PRINTS	PR01463	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01463
PRINTS	PR01470	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01470
PROSITE	PS50042	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50042
PSORT	swissprot:KCNH6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNH6_HUMAN
PSORT-B	swissprot:KCNH6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNH6_HUMAN
PSORT2	swissprot:KCNH6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNH6_HUMAN
Pfam	PF00027	http://pfam.xfam.org/family/PF00027
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF13426	http://pfam.xfam.org/family/PF13426
PharmGKB	PA38722	http://www.pharmgkb.org/do/serve?objId=PA38722&objCls=Gene
Phobius	swissprot:KCNH6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNH6_HUMAN
PhylomeDB	Q9H252	http://phylomedb.org/?seqid=Q9H252
ProteinModelPortal	Q9H252	http://www.proteinmodelportal.org/query/uniprot/Q9H252
PubMed	12634931	http://www.ncbi.nlm.nih.gov/pubmed/12634931
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19139490	http://www.ncbi.nlm.nih.gov/pubmed/19139490
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
RefSeq	NP_001265848	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001265848
RefSeq	NP_001265849	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001265849
RefSeq	NP_110406	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_110406
RefSeq	NP_775115	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_775115
RefSeq	XP_011523612	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011523612
RefSeq	XP_016880664	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016880664
SMART	SM00100	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00100
SMR	Q9H252	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9H252
STRING	9606.ENSP00000463533	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000463533&targetmode=cogs
SUPFAM	SSF51206	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51206
SUPFAM	SSF55785	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55785
UCSC	uc002jax	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002jax&org=rat
UniGene	Hs.591177	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.591177
UniProtKB	KCNH6_HUMAN	http://www.uniprot.org/uniprot/KCNH6_HUMAN
UniProtKB-AC	Q9H252	http://www.uniprot.org/uniprot/Q9H252
charge	swissprot:KCNH6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNH6_HUMAN
eggNOG	ENOG410XPSE	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPSE
eggNOG	KOG0498	http://eggnogapi.embl.de/nog_data/html/tree/KOG0498
epestfind	swissprot:KCNH6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNH6_HUMAN
garnier	swissprot:KCNH6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNH6_HUMAN
helixturnhelix	swissprot:KCNH6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNH6_HUMAN
hmoment	swissprot:KCNH6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNH6_HUMAN
iep	swissprot:KCNH6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNH6_HUMAN
inforesidue	swissprot:KCNH6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNH6_HUMAN
neXtProt	NX_Q9H252	http://www.nextprot.org/db/entry/NX_Q9H252
octanol	swissprot:KCNH6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNH6_HUMAN
pepcoil	swissprot:KCNH6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNH6_HUMAN
pepdigest	swissprot:KCNH6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNH6_HUMAN
pepinfo	swissprot:KCNH6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNH6_HUMAN
pepnet	swissprot:KCNH6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNH6_HUMAN
pepstats	swissprot:KCNH6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNH6_HUMAN
pepwheel	swissprot:KCNH6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNH6_HUMAN
pepwindow	swissprot:KCNH6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNH6_HUMAN
sigcleave	swissprot:KCNH6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNH6_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	MCLN2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8IZK6-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q8IZK6-2; Sequence=VSP_034642; 
# CCDS	CCDS30762	-. [Q8IZK6-1]
# CCDS	CCDS81347	-. [Q8IZK6-2]
# Ensembl	ENST00000284027	ENSP00000284027; ENSG00000153898. [Q8IZK6-2]
# Ensembl	ENST00000370608	ENSP00000359640; ENSG00000153898. [Q8IZK6-1]
# ExpressionAtlas	Q8IZK6	baseline and differential
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005262	calcium channel activity; TAS:Reactome.
# GO_process	GO:0070588	calcium ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q8IZK6	HS
# HGNC	HGNC:13357	MCOLN2
# InterPro	IPR013122	PKD1_2_channel
# KEGG_Brite	ko04040	Ion channels
# MIM	607399	gene
# Organism	MCLN2_HUMAN	Homo sapiens (Human)
# Pfam	PF08016	PKD_channel
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-3295583	TRP channels
# RecName	MCLN2_HUMAN	Mucolipin-2
# RefSeq	NP_001317576	NM_001330647.1
# RefSeq	NP_694991	NM_153259.3. [Q8IZK6-1]
# RefSeq	XP_005270776	XM_005270719.3. [Q8IZK6-2]
# RefSeq	XP_011539489	XM_011541187.2. [Q8IZK6-2]
# RefSeq	XP_011539490	XM_011541188.2. [Q8IZK6-2]
# SEQUENCE CAUTION	Sequence=BAC04267.1; Type=Erroneous termination; Positions=64; Note=Translated as Trp.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the transient receptor (TC 1.A.4) family. Polycystin subfamily. MCOLN2 sub-subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	MCLN2_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	1.A.5.3	the polycystin cation channel (pcc) family
# UCSC	uc001dkm	human. [Q8IZK6-1]
# eggNOG	ENOG410Z1HH	LUCA
# eggNOG	KOG3733	Eukaryota
BLAST	swissprot:MCLN2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MCLN2_HUMAN
COXPRESdb	255231	http://coxpresdb.jp/data/gene/255231.shtml
CleanEx	HS_MCOLN2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_MCOLN2
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.222425399	http://dx.doi.org/10.1073/pnas.222425399
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AK094010	http://www.ebi.ac.uk/ena/data/view/AK094010
EMBL	AL139150	http://www.ebi.ac.uk/ena/data/view/AL139150
EMBL	AY083533	http://www.ebi.ac.uk/ena/data/view/AY083533
EMBL	BC104891	http://www.ebi.ac.uk/ena/data/view/BC104891
EMBL	BC104893	http://www.ebi.ac.uk/ena/data/view/BC104893
EMBL	CH471097	http://www.ebi.ac.uk/ena/data/view/CH471097
Ensembl	ENST00000284027	http://www.ensembl.org/id/ENST00000284027
Ensembl	ENST00000370608	http://www.ensembl.org/id/ENST00000370608
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	MCOLN2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=MCOLN2
GeneID	255231	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=255231
GeneTree	ENSGT00390000017126	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000017126
HGNC	HGNC:13357	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13357
HOGENOM	HOG000232158	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000232158&db=HOGENOM6
HOVERGEN	HBG052430	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052430&db=HOVERGEN
HPA	HPA019114	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA019114
HPA	HPA048999	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA048999
InParanoid	Q8IZK6	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8IZK6
InterPro	IPR013122	http://www.ebi.ac.uk/interpro/entry/IPR013122
Jabion	255231	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=255231
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:255231	http://www.genome.jp/dbget-bin/www_bget?hsa:255231
KEGG_Orthology	KO:K04993	http://www.genome.jp/dbget-bin/www_bget?KO:K04993
MIM	607399	http://www.ncbi.nlm.nih.gov/omim/607399
OMA	CKDWHIL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CKDWHIL
OrthoDB	EOG091G026A	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G026A
PSORT	swissprot:MCLN2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MCLN2_HUMAN
PSORT-B	swissprot:MCLN2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MCLN2_HUMAN
PSORT2	swissprot:MCLN2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MCLN2_HUMAN
Pfam	PF08016	http://pfam.xfam.org/family/PF08016
PharmGKB	PA134913691	http://www.pharmgkb.org/do/serve?objId=PA134913691&objCls=Gene
Phobius	swissprot:MCLN2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MCLN2_HUMAN
PhylomeDB	Q8IZK6	http://phylomedb.org/?seqid=Q8IZK6
ProteinModelPortal	Q8IZK6	http://www.proteinmodelportal.org/query/uniprot/Q8IZK6
PubMed	12403827	http://www.ncbi.nlm.nih.gov/pubmed/12403827
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
Reactome	R-HSA-3295583	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3295583
RefSeq	NP_001317576	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001317576
RefSeq	NP_694991	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_694991
RefSeq	XP_005270776	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005270776
RefSeq	XP_011539489	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011539489
RefSeq	XP_011539490	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011539490
STRING	9606.ENSP00000359640	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000359640&targetmode=cogs
TCDB	1.A.5.3	http://www.tcdb.org/search/result.php?tc=1.A.5.3
UCSC	uc001dkm	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001dkm&org=rat
UniGene	Hs.591446	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.591446
UniProtKB	MCLN2_HUMAN	http://www.uniprot.org/uniprot/MCLN2_HUMAN
UniProtKB-AC	Q8IZK6	http://www.uniprot.org/uniprot/Q8IZK6
charge	swissprot:MCLN2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MCLN2_HUMAN
eggNOG	ENOG410Z1HH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z1HH
eggNOG	KOG3733	http://eggnogapi.embl.de/nog_data/html/tree/KOG3733
epestfind	swissprot:MCLN2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MCLN2_HUMAN
garnier	swissprot:MCLN2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MCLN2_HUMAN
helixturnhelix	swissprot:MCLN2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MCLN2_HUMAN
hmoment	swissprot:MCLN2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MCLN2_HUMAN
iep	swissprot:MCLN2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MCLN2_HUMAN
inforesidue	swissprot:MCLN2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MCLN2_HUMAN
neXtProt	NX_Q8IZK6	http://www.nextprot.org/db/entry/NX_Q8IZK6
octanol	swissprot:MCLN2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MCLN2_HUMAN
pepcoil	swissprot:MCLN2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MCLN2_HUMAN
pepdigest	swissprot:MCLN2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MCLN2_HUMAN
pepinfo	swissprot:MCLN2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MCLN2_HUMAN
pepnet	swissprot:MCLN2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MCLN2_HUMAN
pepstats	swissprot:MCLN2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MCLN2_HUMAN
pepwheel	swissprot:MCLN2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MCLN2_HUMAN
pepwindow	swissprot:MCLN2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MCLN2_HUMAN
sigcleave	swissprot:MCLN2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MCLN2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ASIC3_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9UHC3-1; Sequence=Displayed; Name=2; Synonyms=ASIC3b; IsoId=Q9UHC3-2; Sequence=VSP_015602; Name=3; Synonyms=ASIC3c; IsoId=Q9UHC3-3; Sequence=VSP_015603; Name=4; Synonyms=c; IsoId=Q9UHC3-4; Sequence=VSP_015600, VSP_015601; 
# AltName	ASIC3_HUMAN	Amiloride-sensitive cation channel 3
# AltName	ASIC3_HUMAN	Neuronal amiloride-sensitive cation channel 3
# AltName	ASIC3_HUMAN	Testis sodium channel 1
# BioGrid	114723	7
# CCDS	CCDS5914	-. [Q9UHC3-2]
# CCDS	CCDS5915	-. [Q9UHC3-3]
# CCDS	CCDS5916	-. [Q9UHC3-1]
# ChiTaRS	ASIC3	human
# DEVELOPMENTAL STAGE	Expressed in fetal tissues, expression increases in lung and kidney adult tissues. {ECO:0000269|PubMed	9886053}. 
# DOMAIN	ASIC3_HUMAN	The PDZ domain-binding motif is involved in interaction with LIN7A, GOPC and MAGI1. 
# Ensembl	ENST00000297512	ENSP00000297512; ENSG00000213199. [Q9UHC3-3]
# Ensembl	ENST00000349064	ENSP00000344838; ENSG00000213199. [Q9UHC3-1]
# Ensembl	ENST00000357922	ENSP00000350600; ENSG00000213199. [Q9UHC3-2]
# Ensembl	ENST00000377904	ENSP00000367136; ENSG00000213199. [Q9UHC3-4]
# Ensembl	ENST00000468325	ENSP00000418605; ENSG00000213199. [Q9UHC3-4]
# ExpressionAtlas	Q9UHC3	baseline and differential
# FUNCTION	ASIC3_HUMAN	Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. {ECO 0000269|PubMed 9744806, ECO 0000269|PubMed 9886053}. 
# GO_component	GO:0005737	cytoplasm; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_function	GO:0005261	cation channel activity; TAS:ProtInc.
# GO_function	GO:0005272	sodium channel activity; TAS:ProtInc.
# GO_function	GO:0042931	enterobactin transporter activity; IEA:Ensembl.
# GO_function	GO:0044736	acid-sensing ion channel activity; TAS:Reactome.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0007600	sensory perception; TAS:ProtInc.
# GO_process	GO:0009408	response to heat; IEA:Ensembl.
# GO_process	GO:0010447	response to acidic pH; IEA:Ensembl.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0050915	sensory perception of sour taste; IMP:UniProtKB.
# GO_process	GO:0050965	detection of temperature stimulus involved in sensory perception of pain; IEA:Ensembl.
# GO_process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain; IEA:Ensembl.
# GO_process	GO:0050968	detection of chemical stimulus involved in sensory perception of pain; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9UHC3	HS
# HGNC	HGNC:101	ASIC3
# InterPro	IPR001873	Na+channel_ASC
# InterPro	IPR004724	ENaC
# InterPro	IPR020903	Na+channel_ASC_CS
# KEGG_Brite	ko04040	Ion channels
# MIM	611741	gene
# MISCELLANEOUS	Potentiated by FMRFamide-related neuropeptides. Sensitized and potentiated by NPSF. Regulated by lactate and Ca(2+). Inhibited by anti-inflammatory drugs, like salicylic acid (By similarity). Sensitized and potentiated by NPFF. {ECO	0000250}. 
# Organism	ASIC3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11690	PTHR11690
# PIR	JE0091	JE0091
# PRINTS	PR01078	AMINACHANNEL
# PROSITE	PS01206	ASC
# PTM	ASIC3_HUMAN	Phosphorylated by PKA. Phosphorylated by PKC. In vitro, PRKCABP/PICK-1 is necessary for PKC phosphorylation and activation of a ASIC3/ACCN3-ASIC2/ASIC2b channel, but does not activate a homomeric ASIC3 channel (By similarity). {ECO 0000250}. 
# Pfam	PF00858	ASC
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	ASIC3_HUMAN	Acid-sensing ion channel 3
# RefSeq	NP_004760	NM_004769.3. [Q9UHC3-1]
# RefSeq	NP_064717	NM_020321.3. [Q9UHC3-3]
# RefSeq	NP_064718	NM_020322.3. [Q9UHC3-2]
# SEQUENCE CAUTION	Sequence=BAA25897.1; Type=Frameshift; Positions=303, 305, 313; Evidence={ECO:0000305}; Sequence=BAD92658.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC3 subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	ASIC3_HUMAN	Cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Cytoplasm {ECO 0000250}. Note=Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells (By similarity). {ECO 0000250}. 
# SUBUNIT	ASIC3_HUMAN	Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with STOM; this regulates channel activity. Interacts with DLG4 (By similarity). Interacts with LIN7B, MAGI1/BAIAP1, GOPC and ASIC2. {ECO 0000250, ECO 0000269|PubMed 10842183, ECO 0000269|PubMed 15317815}. 
# TIGRFAMs	TIGR00859	ENaC
# TISSUE SPECIFICITY	ASIC3_HUMAN	Expressed by sensory neurons. Strongly expressed in brain, spinal chord, lung, lymph nodes, kidney, pituitary, heart and testis. {ECO 0000269|PubMed 9571199, ECO 0000269|PubMed 9886053}. 
# UCSC	uc003win	human. [Q9UHC3-1]
# eggNOG	ENOG410ZNFK	LUCA
# eggNOG	KOG4294	Eukaryota
BLAST	swissprot:ASIC3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ASIC3_HUMAN
BioCyc	ZFISH:G66-32073-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32073-MONOMER
COXPRESdb	9311	http://coxpresdb.jp/data/gene/9311.shtml
CleanEx	HS_ACCN3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ACCN3
DOI	10.1006/bbrc.1998.8483	http://dx.doi.org/10.1006/bbrc.1998.8483
DOI	10.1016/S0014-5793(98)00916-8	http://dx.doi.org/10.1016/S0014-5793(98)00916-8
DOI	10.1016/S0028-3908(01)00107-1	http://dx.doi.org/10.1016/S0028-3908(01)00107-1
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1046/j.1471-4159.1999.0720051.x	http://dx.doi.org/10.1046/j.1471-4159.1999.0720051.x
DOI	10.1073/pnas.252782799	http://dx.doi.org/10.1073/pnas.252782799
DOI	10.1074/jbc.M004114200	http://dx.doi.org/10.1074/jbc.M004114200
DOI	10.1074/jbc.M405874200	http://dx.doi.org/10.1074/jbc.M405874200
EMBL	AB010575	http://www.ebi.ac.uk/ena/data/view/AB010575
EMBL	AB209421	http://www.ebi.ac.uk/ena/data/view/AB209421
EMBL	AF057711	http://www.ebi.ac.uk/ena/data/view/AF057711
EMBL	AF095897	http://www.ebi.ac.uk/ena/data/view/AF095897
EMBL	AF195024	http://www.ebi.ac.uk/ena/data/view/AF195024
EMBL	AF195025	http://www.ebi.ac.uk/ena/data/view/AF195025
EMBL	AK313926	http://www.ebi.ac.uk/ena/data/view/AK313926
EMBL	CH471173	http://www.ebi.ac.uk/ena/data/view/CH471173
Ensembl	ENST00000297512	http://www.ensembl.org/id/ENST00000297512
Ensembl	ENST00000349064	http://www.ensembl.org/id/ENST00000349064
Ensembl	ENST00000357922	http://www.ensembl.org/id/ENST00000357922
Ensembl	ENST00000377904	http://www.ensembl.org/id/ENST00000377904
Ensembl	ENST00000468325	http://www.ensembl.org/id/ENST00000468325
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005261	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005261
GO_function	GO:0005272	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005272
GO_function	GO:0042931	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042931
GO_function	GO:0044736	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044736
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007600	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007600
GO_process	GO:0009408	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408
GO_process	GO:0010447	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010447
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0050915	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050915
GO_process	GO:0050965	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050965
GO_process	GO:0050966	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050966
GO_process	GO:0050968	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050968
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ASIC3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ASIC3
GeneID	9311	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9311
GeneTree	ENSGT00760000119120	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119120
HGNC	HGNC:101	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:101
HOVERGEN	HBG004150	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004150&db=HOVERGEN
HPA	HPA049155	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA049155
InParanoid	Q9UHC3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UHC3
InterPro	IPR001873	http://www.ebi.ac.uk/interpro/entry/IPR001873
InterPro	IPR004724	http://www.ebi.ac.uk/interpro/entry/IPR004724
InterPro	IPR020903	http://www.ebi.ac.uk/interpro/entry/IPR020903
Jabion	9311	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9311
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:9311	http://www.genome.jp/dbget-bin/www_bget?hsa:9311
KEGG_Orthology	KO:K04830	http://www.genome.jp/dbget-bin/www_bget?KO:K04830
MIM	611741	http://www.ncbi.nlm.nih.gov/omim/611741
OMA	TCPNPCA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TCPNPCA
PANTHER	PTHR11690	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11690
PRINTS	PR01078	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01078
PROSITE	PS01206	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01206
PSORT	swissprot:ASIC3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ASIC3_HUMAN
PSORT-B	swissprot:ASIC3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ASIC3_HUMAN
PSORT2	swissprot:ASIC3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ASIC3_HUMAN
Pfam	PF00858	http://pfam.xfam.org/family/PF00858
PharmGKB	PA24435	http://www.pharmgkb.org/do/serve?objId=PA24435&objCls=Gene
Phobius	swissprot:ASIC3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ASIC3_HUMAN
PhylomeDB	Q9UHC3	http://phylomedb.org/?seqid=Q9UHC3
ProteinModelPortal	Q9UHC3	http://www.proteinmodelportal.org/query/uniprot/Q9UHC3
PubMed	10842183	http://www.ncbi.nlm.nih.gov/pubmed/10842183
PubMed	11587714	http://www.ncbi.nlm.nih.gov/pubmed/11587714
PubMed	12578970	http://www.ncbi.nlm.nih.gov/pubmed/12578970
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15317815	http://www.ncbi.nlm.nih.gov/pubmed/15317815
PubMed	9571199	http://www.ncbi.nlm.nih.gov/pubmed/9571199
PubMed	9744806	http://www.ncbi.nlm.nih.gov/pubmed/9744806
PubMed	9886053	http://www.ncbi.nlm.nih.gov/pubmed/9886053
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_004760	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004760
RefSeq	NP_064717	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_064717
RefSeq	NP_064718	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_064718
SMR	Q9UHC3	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9UHC3
STRING	9606.ENSP00000297512	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000297512&targetmode=cogs
TIGRFAMs	TIGR00859	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00859
UCSC	uc003win	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003win&org=rat
UniGene	Hs.647113	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.647113
UniProtKB	ASIC3_HUMAN	http://www.uniprot.org/uniprot/ASIC3_HUMAN
UniProtKB-AC	Q9UHC3	http://www.uniprot.org/uniprot/Q9UHC3
charge	swissprot:ASIC3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ASIC3_HUMAN
eggNOG	ENOG410ZNFK	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZNFK
eggNOG	KOG4294	http://eggnogapi.embl.de/nog_data/html/tree/KOG4294
epestfind	swissprot:ASIC3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ASIC3_HUMAN
garnier	swissprot:ASIC3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ASIC3_HUMAN
helixturnhelix	swissprot:ASIC3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ASIC3_HUMAN
hmoment	swissprot:ASIC3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ASIC3_HUMAN
iep	swissprot:ASIC3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ASIC3_HUMAN
inforesidue	swissprot:ASIC3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ASIC3_HUMAN
neXtProt	NX_Q9UHC3	http://www.nextprot.org/db/entry/NX_Q9UHC3
octanol	swissprot:ASIC3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ASIC3_HUMAN
pepcoil	swissprot:ASIC3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ASIC3_HUMAN
pepdigest	swissprot:ASIC3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ASIC3_HUMAN
pepinfo	swissprot:ASIC3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ASIC3_HUMAN
pepnet	swissprot:ASIC3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ASIC3_HUMAN
pepstats	swissprot:ASIC3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ASIC3_HUMAN
pepwheel	swissprot:ASIC3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ASIC3_HUMAN
pepwindow	swissprot:ASIC3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ASIC3_HUMAN
sigcleave	swissprot:ASIC3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ASIC3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NP58-1; Sequence=Displayed; Name=2; IsoId=Q9NP58-4; Sequence=VSP_021973; Note=Ref.4 (BAB71347) sequence differs from that shown due to splicing through aberrant splice sites. {ECO	0000305}; 
# AltName	ABCB6_HUMAN	Mitochondrial ABC transporter 3
# AltName	ABCB6_HUMAN	P-glycoprotein-related protein
# AltName	ABCB6_HUMAN	Ubiquitously-expressed mammalian ABC half transporter
# BioGrid	115369	19
# CCDS	CCDS2436	-. [Q9NP58-1]
# ChiTaRS	ABCB6	human
# DEVELOPMENTAL STAGE	Highly expressed in fetal liver. {ECO:0000269|PubMed	17006453}. 
# DISEASE	ABCB6_HUMAN	Dyschromatosis universalis hereditaria 3 (DUH3) [MIM 615402]  An autosomal dominant pigmentary genodermatosis characterized by a mixture of hyperpigmented and hypopigmented macules distributed randomly over the body, that appear in infancy or early childhood. The trunk and extremities are the dominant sites of abnormal pigmentation. Facial lesions can be seen in 50% of affected individuals, but involvement of palms and soles is unusual. Abnormalities of hair and nails have also been reported. Dyschromatosis universalis hereditaria may be associated with abnormalities of dermal connective tissue, nerve tissue, or other systemic complications. {ECO 0000269|PubMed 23519333, ECO 0000269|PubMed 24224009, ECO 0000269|PubMed 24498303, ECO 0000269|PubMed 25288164}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ABCB6_HUMAN	Microphthalmia, isolated, with coloboma, 7 (MCOPCB7) [MIM 614497]  A disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, and other abnormalities may also be present. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). {ECO 0000269|PubMed 22226084}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ABCB6_HUMAN	Pseudohyperkalemia, familial, 2, due to red cell leak (PSHK2) [MIM 609153]  A dominantly inherited condition characterized by increased serum potassium levels, measured in whole-blood specimens stored at or below room temperature. This condition is not accompanied by clinical symptoms or biological signs except for borderline abnormalities of red cell shape. {ECO 0000269|PubMed 23180570, ECO 0000269|PubMed 24947683}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000265316	ENSP00000265316; ENSG00000115657. [Q9NP58-1]
# ExpressionAtlas	Q9NP58	baseline and differential
# FUNCTION	ABCB6_HUMAN	Binds heme and porphyrins and functions in their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis. {ECO 0000269|PubMed 10837493, ECO 0000269|PubMed 17006453}. 
# GO_component	GO:0000139	Golgi membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005740	mitochondrial envelope; IDA:MGI.
# GO_component	GO:0005741	mitochondrial outer membrane; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; IBA:GO_Central.
# GO_component	GO:0005768	endosome; ISS:UniProtKB.
# GO_component	GO:0005783	endoplasmic reticulum; IDA:UniProtKB.
# GO_component	GO:0005789	endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005794	Golgi apparatus; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0010008	endosome membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0031307	integral component of mitochondrial outer membrane; IDA:UniProtKB.
# GO_component	GO:0043190	ATP-binding cassette (ABC) transporter complex; NAS:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005524	ATP binding; IDA:MGI.
# GO_function	GO:0015232	heme transporter activity; TAS:Reactome.
# GO_function	GO:0015439	heme-transporting ATPase activity; IMP:UniProtKB.
# GO_function	GO:0015562	efflux transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0020037	heme binding; IDA:UniProtKB.
# GO_process	GO:0006779	porphyrin-containing compound biosynthetic process; IDA:UniProtKB.
# GO_process	GO:0006810	transport; IDA:MGI.
# GO_process	GO:0006879	cellular iron ion homeostasis; NAS:UniProtKB.
# GO_process	GO:0007420	brain development; IMP:UniProtKB.
# GO_process	GO:0015886	heme transport; IDA:UniProtKB.
# GO_process	GO:0043588	skin development; IMP:UniProtKB.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0051186	cofactor metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 1.
# Genevisible	Q9NP58	HS
# HGNC	HGNC:47	ABCB6
# INDUCTION	ABCB6_HUMAN	Up-regulated by cellular porphyrins (at protein level). Up-regulated during erythroid differentiation (at protein level). {ECO 0000269|PubMed 17006453, ECO 0000269|PubMed 23180570}. 
# IntAct	Q9NP58	5
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR011527	ABC1_TM_dom
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR027417	P-loop_NTPase
# InterPro	IPR032410	MTABC_N
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko02010	ABC transporters
# MIM	111600	phenotype
# MIM	605452	gene
# MIM	609153	phenotype
# MIM	614497	phenotype
# MIM	615402	phenotype
# MISCELLANEOUS	ABCB6_HUMAN	Depletion of Abcb6 by RNAi abrogates heme biosynthesis. Overexpression enhances porphyrin biosynthesis. 
# Organism	ABCB6_HUMAN	Homo sapiens (Human)
# Orphanet	194	Ocular coloboma
# Orphanet	241	Dyschromatosis universalis
# Orphanet	98938	Colobomatous microphthalmia
# PDB	3NH6	X-ray; 2.00 A; A=558-842
# PDB	3NH9	X-ray; 2.10 A; A=558-842
# PDB	3NHA	X-ray; 2.10 A; A=558-842
# PDB	3NHB	X-ray; 2.15 A; A=558-842
# POLYMORPHISM	Genetic variations in ABCB6 define the Langereis blood group system (LAN) [MIM:111600]. Individuals with Lan(-) blood group lack the Lan antigen on their red blood cells. These individuals may have anti-Lan antibodies in their serum, which can cause transfusion reactions or hemolytic disease of the fetus or newborn. The Lan(-) blood group is only clinically significant in transfusion settings or during pregnancy; otherwise Lan(-) individuals have no clinical features. {ECO	0000269|PubMed:22246506}. 
# PROSITE	PS00211	ABC_TRANSPORTER_1
# PROSITE	PS50893	ABC_TRANSPORTER_2
# PROSITE	PS50929	ABC_TM1F
# Pfam	PF00005	ABC_tran
# Pfam	PF00664	ABC_membrane
# Pfam	PF16185	MTABC_N
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-1369007	Mitochondrial ABC transporters
# RecName	ABCB6_HUMAN	ATP-binding cassette sub-family B member 6, mitochondrial
# RefSeq	NP_005680	NM_005689.2. [Q9NP58-1]
# SEQUENCE CAUTION	ABCB6_HUMAN	Sequence=AAG33617.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=AAG33618.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=AAH43423.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO 0000305}; Sequence=BAD18782.1; Type=Erroneous termination; Positions=168; Note=Translated as Trp.; Evidence={ECO 0000305}; Sequence=BAD92291.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO 0000305}; 
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule	PRU00441}. 
# SIMILARITY	Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA
# SUBCELLULAR LOCATION	ABCB6_HUMAN	Cell membrane {ECO 0000269|PubMed 17661442, ECO 0000269|PubMed 23180570}; Multi-pass membrane protein {ECO 0000255}. Mitochondrion outer membrane {ECO 0000269|PubMed 17006453, ECO 0000269|PubMed 17661442, ECO 0000305|PubMed 10837493}; Multi-pass membrane protein {ECO 0000255}. Endoplasmic reticulum membrane {ECO 0000269|PubMed 18279659, ECO 0000269|PubMed 22226084}; Multi- pass membrane protein {ECO 0000255}. Golgi apparatus membrane {ECO 0000269|PubMed 18279659, ECO 0000269|PubMed 22226084}; Multi- pass membrane protein {ECO 0000255}. Endosome membrane {ECO 0000250|UniProtKB Q9DC29}; Multi-pass membrane protein {ECO 0000255}. Note=localized to the endosome-like compartement and dendrite tips. {ECO 0000250|UniProtKB Q9DC29}. 
# SUBUNIT	ABCB6_HUMAN	Homodimer. {ECO 0000269|PubMed 16791740, ECO 0000269|PubMed 17006453}. 
# SUPFAM	SSF52540	SSF52540
# SUPFAM	SSF90123	SSF90123
# TCDB	3.A.1.210	the atp-binding cassette (abc) superfamily
# TISSUE SPECIFICITY	ABCB6_HUMAN	Widely expressed. High expression is detected in the retinal epithelium. {ECO 0000269|PubMed 10837493, ECO 0000269|PubMed 22226084}. 
# UCSC	uc002vkc	human. [Q9NP58-1]
# WEB RESOURCE	ABCB6_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=Q9NP58";
# eggNOG	COG5265	LUCA
# eggNOG	KOG0057	Eukaryota
BLAST	swissprot:ABCB6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCB6_HUMAN
BioCyc	ZFISH:HS03923-MONOMER	http://biocyc.org/getid?id=ZFISH:HS03923-MONOMER
COXPRESdb	10058	http://coxpresdb.jp/data/gene/10058.shtml
CleanEx	HS_ABCB6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCB6
DOI	10.1002/ajh.23357	http://dx.doi.org/10.1002/ajh.23357
DOI	10.1007/s10858-006-9000-6	http://dx.doi.org/10.1007/s10858-006-9000-6
DOI	10.1016/S0167-4781(01)00340-2	http://dx.doi.org/10.1016/S0167-4781(01)00340-2
DOI	10.1016/j.ajhg.2011.11.026	http://dx.doi.org/10.1016/j.ajhg.2011.11.026
DOI	10.1016/j.bbrc.2008.02.027	http://dx.doi.org/10.1016/j.bbrc.2008.02.027
DOI	10.1016/j.jdermsci.2014.08.015	http://dx.doi.org/10.1016/j.jdermsci.2014.08.015
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/bi700015m	http://dx.doi.org/10.1021/bi700015m
DOI	10.1038/jid.2013.145	http://dx.doi.org/10.1038/jid.2013.145
DOI	10.1038/nature05125	http://dx.doi.org/10.1038/nature05125
DOI	10.1038/ng.1069	http://dx.doi.org/10.1038/ng.1069
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.275.23.17536	http://dx.doi.org/10.1074/jbc.275.23.17536
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1107/S0907444910028593	http://dx.doi.org/10.1107/S0907444910028593
DOI	10.1111/trf.12757	http://dx.doi.org/10.1111/trf.12757
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1371/journal.pone.0079808	http://dx.doi.org/10.1371/journal.pone.0079808
DOI	10.1371/journal.pone.0087250	http://dx.doi.org/10.1371/journal.pone.0087250
EMBL	AB039371	http://www.ebi.ac.uk/ena/data/view/AB039371
EMBL	AB209054	http://www.ebi.ac.uk/ena/data/view/AB209054
EMBL	AF070598	http://www.ebi.ac.uk/ena/data/view/AF070598
EMBL	AF076775	http://www.ebi.ac.uk/ena/data/view/AF076775
EMBL	AF308472	http://www.ebi.ac.uk/ena/data/view/AF308472
EMBL	AF308473	http://www.ebi.ac.uk/ena/data/view/AF308473
EMBL	AJ289233	http://www.ebi.ac.uk/ena/data/view/AJ289233
EMBL	AK057026	http://www.ebi.ac.uk/ena/data/view/AK057026
EMBL	AK172812	http://www.ebi.ac.uk/ena/data/view/AK172812
EMBL	BC000559	http://www.ebi.ac.uk/ena/data/view/BC000559
EMBL	BC043423	http://www.ebi.ac.uk/ena/data/view/BC043423
Ensembl	ENST00000265316	http://www.ensembl.org/id/ENST00000265316
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005740	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005740
GO_component	GO:0005741	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005741
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0010008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010008
GO_component	GO:0031307	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031307
GO_component	GO:0043190	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0015232	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015232
GO_function	GO:0015439	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015439
GO_function	GO:0015562	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015562
GO_function	GO:0020037	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037
GO_process	GO:0006779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006779
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006879	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006879
GO_process	GO:0007420	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007420
GO_process	GO:0015886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015886
GO_process	GO:0043588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043588
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0051186	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCB6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCB6
GeneID	10058	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10058
GeneTree	ENSGT00440000033373	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00440000033373
HGNC	HGNC:47	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:47
HOVERGEN	HBG080810	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG080810&db=HOVERGEN
HPA	HPA046723	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA046723
InParanoid	Q9NP58	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NP58
IntAct	Q9NP58	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NP58*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR011527	http://www.ebi.ac.uk/interpro/entry/IPR011527
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
InterPro	IPR032410	http://www.ebi.ac.uk/interpro/entry/IPR032410
Jabion	10058	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10058
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:10058	http://www.genome.jp/dbget-bin/www_bget?hsa:10058
KEGG_Orthology	KO:K05661	http://www.genome.jp/dbget-bin/www_bget?KO:K05661
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
MIM	111600	http://www.ncbi.nlm.nih.gov/omim/111600
MIM	605452	http://www.ncbi.nlm.nih.gov/omim/605452
MIM	609153	http://www.ncbi.nlm.nih.gov/omim/609153
MIM	614497	http://www.ncbi.nlm.nih.gov/omim/614497
MIM	615402	http://www.ncbi.nlm.nih.gov/omim/615402
MINT	MINT-3071268	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3071268
OMA	RISPYVL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RISPYVL
Orphanet	194	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=194
Orphanet	241	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=241
Orphanet	98938	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98938
OrthoDB	EOG091G02G4	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02G4
PDB	3NH6	http://www.ebi.ac.uk/pdbe-srv/view/entry/3NH6
PDB	3NH9	http://www.ebi.ac.uk/pdbe-srv/view/entry/3NH9
PDB	3NHA	http://www.ebi.ac.uk/pdbe-srv/view/entry/3NHA
PDB	3NHB	http://www.ebi.ac.uk/pdbe-srv/view/entry/3NHB
PDBsum	3NH6	http://www.ebi.ac.uk/pdbsum/3NH6
PDBsum	3NH9	http://www.ebi.ac.uk/pdbsum/3NH9
PDBsum	3NHA	http://www.ebi.ac.uk/pdbsum/3NHA
PDBsum	3NHB	http://www.ebi.ac.uk/pdbsum/3NHB
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PROSITE	PS50929	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929
PSORT	swissprot:ABCB6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCB6_HUMAN
PSORT-B	swissprot:ABCB6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCB6_HUMAN
PSORT2	swissprot:ABCB6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCB6_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF00664	http://pfam.xfam.org/family/PF00664
Pfam	PF16185	http://pfam.xfam.org/family/PF16185
PharmGKB	PA24388	http://www.pharmgkb.org/do/serve?objId=PA24388&objCls=Gene
Phobius	swissprot:ABCB6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCB6_HUMAN
PhylomeDB	Q9NP58	http://phylomedb.org/?seqid=Q9NP58
ProteinModelPortal	Q9NP58	http://www.proteinmodelportal.org/query/uniprot/Q9NP58
PubMed	10837493	http://www.ncbi.nlm.nih.gov/pubmed/10837493
PubMed	11955620	http://www.ncbi.nlm.nih.gov/pubmed/11955620
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16791740	http://www.ncbi.nlm.nih.gov/pubmed/16791740
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	17006453	http://www.ncbi.nlm.nih.gov/pubmed/17006453
PubMed	17661442	http://www.ncbi.nlm.nih.gov/pubmed/17661442
PubMed	18279659	http://www.ncbi.nlm.nih.gov/pubmed/18279659
PubMed	20823549	http://www.ncbi.nlm.nih.gov/pubmed/20823549
PubMed	22226084	http://www.ncbi.nlm.nih.gov/pubmed/22226084
PubMed	22246506	http://www.ncbi.nlm.nih.gov/pubmed/22246506
PubMed	23180570	http://www.ncbi.nlm.nih.gov/pubmed/23180570
PubMed	23519333	http://www.ncbi.nlm.nih.gov/pubmed/23519333
PubMed	24224009	http://www.ncbi.nlm.nih.gov/pubmed/24224009
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	24498303	http://www.ncbi.nlm.nih.gov/pubmed/24498303
PubMed	24947683	http://www.ncbi.nlm.nih.gov/pubmed/24947683
PubMed	25288164	http://www.ncbi.nlm.nih.gov/pubmed/25288164
Reactome	R-HSA-1369007	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1369007
RefSeq	NP_005680	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005680
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	Q9NP58	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9NP58
STRING	9606.ENSP00000265316	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000265316&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
SUPFAM	SSF90123	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123
TCDB	3.A.1.210	http://www.tcdb.org/search/result.php?tc=3.A.1.210
UCSC	uc002vkc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002vkc&org=rat
UniGene	Hs.107911	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.107911
UniProtKB	ABCB6_HUMAN	http://www.uniprot.org/uniprot/ABCB6_HUMAN
UniProtKB-AC	Q9NP58	http://www.uniprot.org/uniprot/Q9NP58
charge	swissprot:ABCB6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCB6_HUMAN
eggNOG	COG5265	http://eggnogapi.embl.de/nog_data/html/tree/COG5265
eggNOG	KOG0057	http://eggnogapi.embl.de/nog_data/html/tree/KOG0057
epestfind	swissprot:ABCB6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCB6_HUMAN
garnier	swissprot:ABCB6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCB6_HUMAN
helixturnhelix	swissprot:ABCB6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCB6_HUMAN
hmoment	swissprot:ABCB6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCB6_HUMAN
iep	swissprot:ABCB6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCB6_HUMAN
inforesidue	swissprot:ABCB6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCB6_HUMAN
neXtProt	NX_Q9NP58	http://www.nextprot.org/db/entry/NX_Q9NP58
octanol	swissprot:ABCB6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCB6_HUMAN
pepcoil	swissprot:ABCB6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCB6_HUMAN
pepdigest	swissprot:ABCB6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCB6_HUMAN
pepinfo	swissprot:ABCB6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCB6_HUMAN
pepnet	swissprot:ABCB6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCB6_HUMAN
pepstats	swissprot:ABCB6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCB6_HUMAN
pepwheel	swissprot:ABCB6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCB6_HUMAN
pepwindow	swissprot:ABCB6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCB6_HUMAN
sigcleave	swissprot:ABCB6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCB6_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S4A5_HUMAN	Event=Alternative splicing; Named isoforms=8; Name=1 {ECO 0000269|PubMed 11087115}; Synonyms=NBC4a {ECO 0000269|PubMed 11087115}; IsoId=Q9BY07-1; Sequence=Displayed; Name=2 {ECO 0000269|PubMed 10978526, ECO 0000269|PubMed 11087115}; Synonyms=NBC4b {ECO 0000269|PubMed 11087115}; IsoId=Q9BY07-2; Sequence=VSP_052778; Name=3 {ECO 0000269|PubMed 11788353}; Synonyms=NBC4c {ECO 0000269|PubMed 11788353}; IsoId=Q9BY07-3; Sequence=VSP_052776; Name=4 {ECO 0000269|PubMed 12063394}; Synonyms=NBC4d {ECO 0000269|PubMed 12063394}; IsoId=Q9BY07-4; Sequence=VSP_052775; Name=5; Synonyms=isoform d variant; IsoId=Q9BY07-5; Sequence=VSP_052771, VSP_052773, VSP_052777; Note=No experimental confirmation available. Incomplete sequence. {ECO 0000305}; Name=6 {ECO 0000269|PubMed 12388414}; Synonyms=NBC4f {ECO 0000269|PubMed 12388414}; IsoId=Q9BY07-6; Sequence=VSP_052772, VSP_052774, VSP_052776, VSP_052778, VSP_052780, VSP_052781; Name=7 {ECO 0000269|PubMed 15489334}; IsoId=Q9BY07-7; Sequence=VSP_052770, VSP_052772, VSP_052776; Note=No experimental confirmation available. {ECO 0000305}; Name=8 {ECO 0000269|PubMed 12388414}; Synonyms=NBC4e {ECO 0000269|PubMed 12388414}; IsoId=Q9BY07-8; Sequence=VSP_052779; 
# AltName	S4A5_HUMAN	NBCe2
# AltName	S4A5_HUMAN	Solute carrier family 4 member 5
# CCDS	CCDS1936	-. [Q9BY07-1]
# CCDS	CCDS1937	-. [Q9BY07-3]
# ChiTaRS	SLC4A5	human
# DrugBank	DB01390	Sodium bicarbonate
# ENZYME REGULATION	S4A5_HUMAN	Activity is inhibited by 4,4'-di- isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters). 
# Ensembl	ENST00000346834	ENSP00000251768; ENSG00000188687. [Q9BY07-1]
# Ensembl	ENST00000358683	ENSP00000351513; ENSG00000188687. [Q9BY07-7]
# Ensembl	ENST00000377632	ENSP00000366859; ENSG00000188687. [Q9BY07-4]
# Ensembl	ENST00000377634	ENSP00000366861; ENSG00000188687. [Q9BY07-1]
# Ensembl	ENST00000394019	ENSP00000377587; ENSG00000188687. [Q9BY07-3]
# Ensembl	ENST00000423644	ENSP00000395804; ENSG00000188687. [Q9BY07-3]
# ExpressionAtlas	Q9BY07	baseline and differential
# FUNCTION	S4A5_HUMAN	Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+) HCO3(-) stoichiometry of 2 1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+) HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH. {ECO 0000250|UniProtKB Q6RI88, ECO 0000269|PubMed 11788353, ECO 0000269|PubMed 11997242, ECO 0000269|PubMed 12388414}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0005452	inorganic anion exchanger activity; IEA:InterPro.
# GO_function	GO:0008509	anion transmembrane transporter activity; IBA:GO_Central.
# GO_function	S4A5_HUMAN	GO 0008510 sodium bicarbonate symporter activity; NAS UniProtKB.
# GO_function	S4A5_HUMAN	GO 0015301 anion anion antiporter activity; IEA UniProtKB-KW.
# GO_process	GO:0003014	renal system process; IBA:GO_Central.
# GO_process	GO:0015701	bicarbonate transport; NAS:UniProtKB.
# GO_process	GO:0051453	regulation of intracellular pH; IBA:GO_Central.
# GO_process	GO:0098656	anion transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.1100.10	-; 1.
# Genevisible	Q9BY07	HS
# HGNC	HGNC:18168	SLC4A5
# InterPro	IPR003020	HCO3_transpt_euk
# InterPro	IPR003024	Na/HCO3_transpt
# InterPro	IPR011531	HCO3_transpt_C
# InterPro	IPR013769	Band3_cytoplasmic_dom
# InterPro	IPR016152	PTrfase/Anion_transptr
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04976	Bile secretion
# MIM	606757	gene
# Organism	S4A5_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11453	PTHR11453; 3
# PRINTS	PR01231	HCO3TRNSPORT
# PRINTS	PR01232	NAHCO3TRSPRT
# Pfam	PF00955	HCO3_cotransp
# Pfam	PF07565	Band_3_cyto
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-425381	Bicarbonate transporters
# RecName	S4A5_HUMAN	Electrogenic sodium bicarbonate cotransporter 4
# RefSeq	NP_067019	NM_021196.3. [Q9BY07-1]
# RefSeq	NP_597812	NM_133478.2. [Q9BY07-3]
# SEQUENCE CAUTION	Sequence=AAG18492.1; Type=Frameshift; Positions=1047; Evidence={ECO:0000305}; Sequence=AAL50802.1; Type=Frameshift; Positions=760, 925, 1047; Evidence={ECO	0000305}; Sequence=EAW99691.1; Type=Frameshift; Positions=1047; Evidence={ECO:0000305};
# SIMILARITY	Belongs to the anion exchanger (TC 2.A.31) family. {ECO	0000255}. 
# SUBCELLULAR LOCATION	S4A5_HUMAN	Apical cell membrane {ECO 0000269|PubMed 17715183}; Multi-pass membrane protein {ECO 0000269|PubMed 17715183}. Note=Expressed in the apical plasma membrane domain of a subset of collecting ducts in the renal medulla. {ECO 0000269|PubMed 17715183}. 
# SUPFAM	SSF55804	SSF55804
# TCDB	2.A.31.2	the anion exchanger (ae) family
# TIGRFAMs	TIGR00834	ae
# TISSUE SPECIFICITY	S4A5_HUMAN	Highest expression observed in liver, spleen and testis; moderate expression in the choroid plexus, hippocampus, cerebrum and cerebellum of brain, and in kidney cortex and kidney medulla. Also observed in heart, pancreas, muscle, lung, placenta, stomach and small intestine. Weakest expression seen in peripheral blood lymphocytes, colon, duodenum, jejunum, ileum and skeletal muscle. {ECO 0000269|PubMed 10978526, ECO 0000269|PubMed 11087115, ECO 0000269|PubMed 11788353, ECO 0000269|PubMed 17715183}. 
# UCSC	uc002skn	human. [Q9BY07-1]
# eggNOG	ENOG410XPHD	LUCA
# eggNOG	KOG1172	Eukaryota
BLAST	swissprot:S4A5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S4A5_HUMAN
BioCyc	ZFISH:G66-32365-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32365-MONOMER
COXPRESdb	57835	http://coxpresdb.jp/data/gene/57835.shtml
CleanEx	HS_SLC4A5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC4A5
DOI	10.1016/S0167-4781(00)00149-4	http://dx.doi.org/10.1016/S0167-4781(00)00149-4
DOI	10.1080/15216540050176539	http://dx.doi.org/10.1080/15216540050176539
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1152/ajpcell.00409.2001	http://dx.doi.org/10.1152/ajpcell.00409.2001
DOI	10.1152/ajpcell.00589.2001	http://dx.doi.org/10.1152/ajpcell.00589.2001
DOI	10.1152/ajpregu.00356.2007	http://dx.doi.org/10.1152/ajpregu.00356.2007
DrugBank	DB01390	http://www.drugbank.ca/drugs/DB01390
EMBL	AB209752	http://www.ebi.ac.uk/ena/data/view/AB209752
EMBL	AF207661	http://www.ebi.ac.uk/ena/data/view/AF207661
EMBL	AF243499	http://www.ebi.ac.uk/ena/data/view/AF243499
EMBL	AF293337	http://www.ebi.ac.uk/ena/data/view/AF293337
EMBL	AF293338	http://www.ebi.ac.uk/ena/data/view/AF293338
EMBL	AF452248	http://www.ebi.ac.uk/ena/data/view/AF452248
EMBL	AF453528	http://www.ebi.ac.uk/ena/data/view/AF453528
EMBL	BC109221	http://www.ebi.ac.uk/ena/data/view/BC109221
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
Ensembl	ENST00000346834	http://www.ensembl.org/id/ENST00000346834
Ensembl	ENST00000358683	http://www.ensembl.org/id/ENST00000358683
Ensembl	ENST00000377632	http://www.ensembl.org/id/ENST00000377632
Ensembl	ENST00000377634	http://www.ensembl.org/id/ENST00000377634
Ensembl	ENST00000394019	http://www.ensembl.org/id/ENST00000394019
Ensembl	ENST00000423644	http://www.ensembl.org/id/ENST00000423644
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_function	GO:0005452	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005452
GO_function	GO:0008509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008509
GO_function	GO:0008510	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008510
GO_function	GO:0015301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015301
GO_process	GO:0003014	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003014
GO_process	GO:0015701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015701
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GO_process	GO:0098656	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098656
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.1100.10	http://www.cathdb.info/version/latest/superfamily/3.40.1100.10
GeneCards	SLC4A5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC4A5
GeneID	57835	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57835
GeneTree	ENSGT00760000119021	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119021
HGNC	HGNC:18168	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18168
HOVERGEN	HBG004326	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004326&db=HOVERGEN
InParanoid	Q9BY07	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9BY07
IntAct	Q9BY07	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9BY07*
InterPro	IPR003020	http://www.ebi.ac.uk/interpro/entry/IPR003020
InterPro	IPR003024	http://www.ebi.ac.uk/interpro/entry/IPR003024
InterPro	IPR011531	http://www.ebi.ac.uk/interpro/entry/IPR011531
InterPro	IPR013769	http://www.ebi.ac.uk/interpro/entry/IPR013769
InterPro	IPR016152	http://www.ebi.ac.uk/interpro/entry/IPR016152
Jabion	57835	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=57835
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:57835	http://www.genome.jp/dbget-bin/www_bget?hsa:57835
KEGG_Orthology	KO:K13857	http://www.genome.jp/dbget-bin/www_bget?KO:K13857
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
MIM	606757	http://www.ncbi.nlm.nih.gov/omim/606757
MINT	MINT-6489517	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6489517
OMA	ELIWTGR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ELIWTGR
OrthoDB	EOG091G01FT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01FT
PANTHER	PTHR11453	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11453
PRINTS	PR01231	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01231
PRINTS	PR01232	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01232
PSORT	swissprot:S4A5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S4A5_HUMAN
PSORT-B	swissprot:S4A5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S4A5_HUMAN
PSORT2	swissprot:S4A5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S4A5_HUMAN
Pfam	PF00955	http://pfam.xfam.org/family/PF00955
Pfam	PF07565	http://pfam.xfam.org/family/PF07565
PharmGKB	PA164742397	http://www.pharmgkb.org/do/serve?objId=PA164742397&objCls=Gene
Phobius	swissprot:S4A5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S4A5_HUMAN
PhylomeDB	Q9BY07	http://phylomedb.org/?seqid=Q9BY07
ProteinModelPortal	Q9BY07	http://www.proteinmodelportal.org/query/uniprot/Q9BY07
PubMed	10978526	http://www.ncbi.nlm.nih.gov/pubmed/10978526
PubMed	11087115	http://www.ncbi.nlm.nih.gov/pubmed/11087115
PubMed	11788353	http://www.ncbi.nlm.nih.gov/pubmed/11788353
PubMed	11997242	http://www.ncbi.nlm.nih.gov/pubmed/11997242
PubMed	12063394	http://www.ncbi.nlm.nih.gov/pubmed/12063394
PubMed	12388414	http://www.ncbi.nlm.nih.gov/pubmed/12388414
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17715183	http://www.ncbi.nlm.nih.gov/pubmed/17715183
Reactome	R-HSA-425381	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425381
RefSeq	NP_067019	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_067019
RefSeq	NP_597812	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_597812
STRING	9606.ENSP00000350475	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000350475&targetmode=cogs
SUPFAM	SSF55804	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55804
TCDB	2.A.31.2	http://www.tcdb.org/search/result.php?tc=2.A.31.2
TIGRFAMs	TIGR00834	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00834
UCSC	uc002skn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002skn&org=rat
UniGene	Hs.594099	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.594099
UniProtKB	S4A5_HUMAN	http://www.uniprot.org/uniprot/S4A5_HUMAN
UniProtKB-AC	Q9BY07	http://www.uniprot.org/uniprot/Q9BY07
charge	swissprot:S4A5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S4A5_HUMAN
eggNOG	ENOG410XPHD	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPHD
eggNOG	KOG1172	http://eggnogapi.embl.de/nog_data/html/tree/KOG1172
epestfind	swissprot:S4A5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S4A5_HUMAN
garnier	swissprot:S4A5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S4A5_HUMAN
helixturnhelix	swissprot:S4A5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S4A5_HUMAN
hmoment	swissprot:S4A5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S4A5_HUMAN
iep	swissprot:S4A5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S4A5_HUMAN
inforesidue	swissprot:S4A5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S4A5_HUMAN
neXtProt	NX_Q9BY07	http://www.nextprot.org/db/entry/NX_Q9BY07
octanol	swissprot:S4A5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S4A5_HUMAN
pepcoil	swissprot:S4A5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S4A5_HUMAN
pepdigest	swissprot:S4A5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S4A5_HUMAN
pepinfo	swissprot:S4A5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S4A5_HUMAN
pepnet	swissprot:S4A5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S4A5_HUMAN
pepstats	swissprot:S4A5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S4A5_HUMAN
pepwheel	swissprot:S4A5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S4A5_HUMAN
pepwindow	swissprot:S4A5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S4A5_HUMAN
sigcleave	swissprot:S4A5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S4A5_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	NIPA2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N8Q9-1; Sequence=Displayed; Name=2; IsoId=Q8N8Q9-2; Sequence=VSP_044587; Note=Not experimental evidence available.; 
# AltName	NIPA2_HUMAN	Non-imprinted in Prader-Willi/Angelman syndrome region protein 2
# BioGrid	123549	2
# CCDS	CCDS73693	-. [Q8N8Q9-1]
# CCDS	CCDS73694	-. [Q8N8Q9-2]
# Ensembl	ENST00000337451	ENSP00000337618; ENSG00000140157. [Q8N8Q9-1]
# Ensembl	ENST00000359727	ENSP00000352762; ENSG00000140157. [Q8N8Q9-2]
# Ensembl	ENST00000398013	ENSP00000381095; ENSG00000140157. [Q8N8Q9-1]
# Ensembl	ENST00000398014	ENSP00000381096; ENSG00000140157. [Q8N8Q9-1]
# Ensembl	ENST00000539711	ENSP00000437746; ENSG00000140157. [Q8N8Q9-2]
# ExpressionAtlas	Q8N8Q9	baseline and differential
# FUNCTION	NIPA2_HUMAN	Acts as a selective Mg(2+) transporter. {ECO 0000250}. 
# GO_component	GO:0005769	early endosome; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016020	membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015095	magnesium ion transmembrane transporter activity; IEA:InterPro.
# GO_process	GO:0015693	magnesium ion transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q8N8Q9	HS
# HGNC	HGNC:17044	NIPA2
# InterPro	IPR008521	Mg_trans_NIPA
# MIM	608146	gene
# Organism	NIPA2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12570	PTHR12570
# Pfam	PF05653	Mg_trans_NIPA
# Proteomes	UP000005640	Chromosome 15
# Reactome	R-HSA-5223345	Miscellaneous transport and binding events
# RecName	NIPA2_HUMAN	Magnesium transporter NIPA2
# RefSeq	NP_001008860	NM_001008860.2. [Q8N8Q9-1]
# RefSeq	NP_001008892	NM_001008892.2. [Q8N8Q9-1]
# RefSeq	NP_001008894	NM_001008894.2. [Q8N8Q9-2]
# RefSeq	NP_001171817	NM_001184888.1. [Q8N8Q9-2]
# RefSeq	NP_001171818	NM_001184889.1. [Q8N8Q9-1]
# RefSeq	NP_112184	NM_030922.6. [Q8N8Q9-1]
# RefSeq	XP_005272603	XM_005272546.3. [Q8N8Q9-1]
# RefSeq	XP_005272604	XM_005272547.4. [Q8N8Q9-1]
# RefSeq	XP_005272605	XM_005272548.3. [Q8N8Q9-1]
# RefSeq	XP_005272607	XM_005272550.3. [Q8N8Q9-1]
# RefSeq	XP_005272609	XM_005272552.3. [Q8N8Q9-1]
# RefSeq	XP_005272610	XM_005272553.4. [Q8N8Q9-1]
# RefSeq	XP_006720427	XM_006720364.2. [Q8N8Q9-1]
# RefSeq	XP_006720428	XM_006720365.2. [Q8N8Q9-1]
# RefSeq	XP_006720429	XM_006720366.3. [Q8N8Q9-1]
# RefSeq	XP_006720430	XM_006720367.1. [Q8N8Q9-2]
# RefSeq	XP_011542179	XM_011543877.2. [Q8N8Q9-1]
# RefSeq	XP_011542180	XM_011543878.2. [Q8N8Q9-1]
# RefSeq	XP_011542181	XM_011543879.2. [Q8N8Q9-1]
# RefSeq	XP_011542182	XM_011543880.2. [Q8N8Q9-1]
# RefSeq	XP_016878134	XM_017022645.1. [Q8N8Q9-1]
# RefSeq	XP_016878135	XM_017022646.1. [Q8N8Q9-1]
# RefSeq	XP_016878136	XM_017022647.1. [Q8N8Q9-1]
# RefSeq	XP_016878137	XM_017022648.1. [Q8N8Q9-1]
# RefSeq	XP_016878138	XM_017022649.1. [Q8N8Q9-1]
# RefSeq	XP_016878139	XM_017022650.1. [Q8N8Q9-1]
# RefSeq	XP_016878140	XM_017022651.1. [Q8N8Q9-1]
# RefSeq	XP_016878141	XM_017022652.1. [Q8N8Q9-1]
# RefSeq	XP_016878142	XM_017022653.1. [Q8N8Q9-1]
# RefSeq	XP_016878143	XM_017022654.1. [Q8N8Q9-1]
# RefSeq	XP_016878144	XM_017022655.1. [Q8N8Q9-2]
# RefSeq	XP_016878145	XM_017022656.1. [Q8N8Q9-2]
# RefSeq	XP_016878146	XM_017022657.1. [Q8N8Q9-2]
# RefSeq	XP_016878147	XM_017022658.1. [Q8N8Q9-2]
# RefSeq	XP_016878148	XM_017022659.1. [Q8N8Q9-2]
# RefSeq	XP_016878149	XM_017022660.1. [Q8N8Q9-2]
# RefSeq	XP_016878150	XM_017022661.1. [Q8N8Q9-2]
# RefSeq	XP_016878151	XM_017022662.1. [Q8N8Q9-2]
# RefSeq	XP_016878152	XM_017022663.1. [Q8N8Q9-2]
# SIMILARITY	Belongs to the NIPA family. {ECO	0000305}.
# SUBCELLULAR LOCATION	NIPA2_HUMAN	Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. Early endosome {ECO 0000250}. Note=Recruited to the cell membrane in response to low extracellular magnesium. {ECO 0000250}. 
# TCDB	2.A.7.25	the drug/metabolite transporter (dmt) superfamily
# TISSUE SPECIFICITY	Widely expressed. {ECO:0000269|PubMed	14508708}. 
# UCSC	uc001yux	human. [Q8N8Q9-1]
# eggNOG	ENOG410XNR8	LUCA
# eggNOG	KOG2922	Eukaryota
BLAST	swissprot:NIPA2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NIPA2_HUMAN
BioCyc	ZFISH:ENSG00000140157-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000140157-MONOMER
COXPRESdb	81614	http://coxpresdb.jp/data/gene/81614.shtml
CleanEx	HS_NIPA2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_NIPA2
DOI	10.1038/nature04601	http://dx.doi.org/10.1038/nature04601
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1086/378816	http://dx.doi.org/10.1086/378816
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC011767	http://www.ebi.ac.uk/ena/data/view/AC011767
EMBL	AK096305	http://www.ebi.ac.uk/ena/data/view/AK096305
EMBL	AK300843	http://www.ebi.ac.uk/ena/data/view/AK300843
EMBL	AY732242	http://www.ebi.ac.uk/ena/data/view/AY732242
EMBL	BC000957	http://www.ebi.ac.uk/ena/data/view/BC000957
EMBL	BC011775	http://www.ebi.ac.uk/ena/data/view/BC011775
EMBL	BK001120	http://www.ebi.ac.uk/ena/data/view/BK001120
EMBL	CR606982	http://www.ebi.ac.uk/ena/data/view/CR606982
Ensembl	ENST00000337451	http://www.ensembl.org/id/ENST00000337451
Ensembl	ENST00000359727	http://www.ensembl.org/id/ENST00000359727
Ensembl	ENST00000398013	http://www.ensembl.org/id/ENST00000398013
Ensembl	ENST00000398014	http://www.ensembl.org/id/ENST00000398014
Ensembl	ENST00000539711	http://www.ensembl.org/id/ENST00000539711
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005769	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005769
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015095
GO_process	GO:0015693	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015693
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	NIPA2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=NIPA2
GeneID	81614	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81614
GeneTree	ENSGT00550000074395	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074395
HGNC	HGNC:17044	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17044
HOGENOM	HOG000203962	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000203962&db=HOGENOM6
HOVERGEN	HBG055032	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG055032&db=HOVERGEN
HPA	HPA067160	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA067160
HPA	HPA071342	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA071342
InParanoid	Q8N8Q9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8N8Q9
InterPro	IPR008521	http://www.ebi.ac.uk/interpro/entry/IPR008521
Jabion	81614	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=81614
KEGG_Gene	hsa:81614	http://www.genome.jp/dbget-bin/www_bget?hsa:81614
MIM	608146	http://www.ncbi.nlm.nih.gov/omim/608146
OMA	EWEHMGA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EWEHMGA
OrthoDB	EOG091G0M8A	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0M8A
PANTHER	PTHR12570	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12570
PSORT	swissprot:NIPA2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NIPA2_HUMAN
PSORT-B	swissprot:NIPA2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NIPA2_HUMAN
PSORT2	swissprot:NIPA2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NIPA2_HUMAN
Pfam	PF05653	http://pfam.xfam.org/family/PF05653
PharmGKB	PA134911294	http://www.pharmgkb.org/do/serve?objId=PA134911294&objCls=Gene
Phobius	swissprot:NIPA2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NIPA2_HUMAN
PhylomeDB	Q8N8Q9	http://phylomedb.org/?seqid=Q8N8Q9
ProteinModelPortal	Q8N8Q9	http://www.proteinmodelportal.org/query/uniprot/Q8N8Q9
PubMed	14508708	http://www.ncbi.nlm.nih.gov/pubmed/14508708
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16572171	http://www.ncbi.nlm.nih.gov/pubmed/16572171
Reactome	R-HSA-5223345	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5223345
RefSeq	NP_001008860	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001008860
RefSeq	NP_001008892	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001008892
RefSeq	NP_001008894	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001008894
RefSeq	NP_001171817	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001171817
RefSeq	NP_001171818	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001171818
RefSeq	NP_112184	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_112184
RefSeq	XP_005272603	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005272603
RefSeq	XP_005272604	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005272604
RefSeq	XP_005272605	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005272605
RefSeq	XP_005272607	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005272607
RefSeq	XP_005272609	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005272609
RefSeq	XP_005272610	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005272610
RefSeq	XP_006720427	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006720427
RefSeq	XP_006720428	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006720428
RefSeq	XP_006720429	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006720429
RefSeq	XP_006720430	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006720430
RefSeq	XP_011542179	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011542179
RefSeq	XP_011542180	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011542180
RefSeq	XP_011542181	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011542181
RefSeq	XP_011542182	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011542182
RefSeq	XP_016878134	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016878134
RefSeq	XP_016878135	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016878135
RefSeq	XP_016878136	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016878136
RefSeq	XP_016878137	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016878137
RefSeq	XP_016878138	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016878138
RefSeq	XP_016878139	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016878139
RefSeq	XP_016878140	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016878140
RefSeq	XP_016878141	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016878141
RefSeq	XP_016878142	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016878142
RefSeq	XP_016878143	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016878143
RefSeq	XP_016878144	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016878144
RefSeq	XP_016878145	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016878145
RefSeq	XP_016878146	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016878146
RefSeq	XP_016878147	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016878147
RefSeq	XP_016878148	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016878148
RefSeq	XP_016878149	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016878149
RefSeq	XP_016878150	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016878150
RefSeq	XP_016878151	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016878151
RefSeq	XP_016878152	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016878152
STRING	9606.ENSP00000337618	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000337618&targetmode=cogs
TCDB	2.A.7.25	http://www.tcdb.org/search/result.php?tc=2.A.7.25
UCSC	uc001yux	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001yux&org=rat
UniGene	Hs.591003	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.591003
UniProtKB	NIPA2_HUMAN	http://www.uniprot.org/uniprot/NIPA2_HUMAN
UniProtKB-AC	Q8N8Q9	http://www.uniprot.org/uniprot/Q8N8Q9
charge	swissprot:NIPA2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NIPA2_HUMAN
eggNOG	ENOG410XNR8	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNR8
eggNOG	KOG2922	http://eggnogapi.embl.de/nog_data/html/tree/KOG2922
epestfind	swissprot:NIPA2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NIPA2_HUMAN
garnier	swissprot:NIPA2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NIPA2_HUMAN
helixturnhelix	swissprot:NIPA2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NIPA2_HUMAN
hmoment	swissprot:NIPA2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NIPA2_HUMAN
iep	swissprot:NIPA2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NIPA2_HUMAN
inforesidue	swissprot:NIPA2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NIPA2_HUMAN
neXtProt	NX_Q8N8Q9	http://www.nextprot.org/db/entry/NX_Q8N8Q9
octanol	swissprot:NIPA2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NIPA2_HUMAN
pepcoil	swissprot:NIPA2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NIPA2_HUMAN
pepdigest	swissprot:NIPA2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NIPA2_HUMAN
pepinfo	swissprot:NIPA2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NIPA2_HUMAN
pepnet	swissprot:NIPA2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NIPA2_HUMAN
pepstats	swissprot:NIPA2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NIPA2_HUMAN
pepwheel	swissprot:NIPA2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NIPA2_HUMAN
pepwindow	swissprot:NIPA2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NIPA2_HUMAN
sigcleave	swissprot:NIPA2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NIPA2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	STIM2_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9P246-1; Sequence=Displayed; Name=2; IsoId=Q9P246-2; Sequence=VSP_057171, VSP_057172; Note=No experimental confirmation available.; Name=3; IsoId=Q9P246-3; Sequence=VSP_057173, VSP_057174; Note=No experimental confirmation available.; 
# BioGrid	121666	18
# CCDS	CCDS3440	-. [Q9P246-1]
# CCDS	CCDS54752	-. [Q9P246-3]
# CDD	cd11722	SOAR
# ChiTaRS	STIM2	human
# Ensembl	ENST00000412829	ENSP00000404812; ENSG00000109689
# Ensembl	ENST00000467087	ENSP00000419073; ENSG00000109689
# ExpressionAtlas	Q9P246	baseline and differential
# FUNCTION	STIM2_HUMAN	Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO 0000269|PubMed 16005298, ECO 0000269|PubMed 16860747, ECO 0000269|PubMed 17905723, ECO 0000269|PubMed 18160041, ECO 0000269|PubMed 21217057, ECO 0000269|PubMed 22464749, ECO 0000269|PubMed 23359669}. 
# GO_component	GO:0005783	endoplasmic reticulum; IDA:UniProtKB.
# GO_component	GO:0005789	endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005246	calcium channel regulator activity; IMP:UniProtKB.
# GO_function	GO:0005509	calcium ion binding; IDA:UniProtKB.
# GO_function	GO:0015279	store-operated calcium channel activity; IDA:UniProtKB.
# GO_process	GO:0002115	store-operated calcium entry; IBA:GO_Central.
# GO_process	GO:0006874	cellular calcium ion homeostasis; IMP:UniProtKB.
# GO_process	GO:0032237	activation of store-operated calcium channel activity; IDA:UniProtKB.
# GO_process	GO:0051928	positive regulation of calcium ion transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# Gene3D	1.10.150.50	-; 1.
# Genevisible	Q9P246	HS
# HGNC	HGNC:19205	STIM2
# INTERACTION	STIM2_HUMAN	Q13586 STIM1; NbExp=4; IntAct=EBI-448891, EBI-448878; 
# IntAct	Q9P246	6
# InterPro	IPR001660	SAM
# InterPro	IPR013761	SAM/pointed
# InterPro	IPR032393	SOAR
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Pathway	ko04020	Calcium signaling pathway
# MIM	610841	gene
# Organism	STIM2_HUMAN	Homo sapiens (Human)
# PDB	2L5Y	NMR; -; A=62-205
# PROSITE	PS50105	SAM_DOMAIN
# PTM	STIM2_HUMAN	Glycosylated. {ECO 0000269|PubMed 11463338}. 
# PTM	STIM2_HUMAN	Phosphorylated predominantly on Ser residues. {ECO 0000269|PubMed 11463338}. 
# Pfam	PF07647	SAM_2
# Pfam	PF16533	SOAR
# Proteomes	UP000005640	Chromosome 4
# RecName	STIM2_HUMAN	Stromal interaction molecule 2
# RefSeq	NP_001162588	NM_001169117.1. [Q9P246-3]
# RefSeq	NP_001162589	NM_001169118.1
# RefSeq	NP_065911	NM_020860.3. [Q9P246-1]
# SEQUENCE CAUTION	STIM2_HUMAN	Sequence=BAA96006.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO 0000305}; Sequence=BAB14545.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=BAB14545.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO 0000305}; Sequence=CAB66512.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO 0000305};
# SIMILARITY	Contains 1 EF-hand domain. {ECO	0000305}. 
# SIMILARITY	Contains 1 SAM (sterile alpha motif) domain. {ECO:0000255|PROSITE-ProRule	PRU00184}. 
# SUBCELLULAR LOCATION	STIM2_HUMAN	Endoplasmic reticulum membrane {ECO 0000269|PubMed 16860747, ECO 0000269|PubMed 17905723, ECO 0000269|PubMed 18160041}; Single-pass type I membrane protein {ECO 0000269|PubMed 16860747, ECO 0000269|PubMed 17905723, ECO 0000269|PubMed 18160041}. Note=Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration. 
# SUBUNIT	STIM2_HUMAN	Oligomer with STIM1. Interacts with ORAI1. {ECO 0000269|PubMed 11463338, ECO 0000269|PubMed 17905723, ECO 0000269|PubMed 21217057}. 
# SUPFAM	SSF47769	SSF47769
# TCDB	1.A.52.1	the ca(2+) release-activated ca(2+) (crac) channel (crac-c) family
# TISSUE SPECIFICITY	Expressed in all tissues and tumor cell lines examined. {ECO:0000269|PubMed	11463338}. 
# UCSC	uc003gsg	human. [Q9P246-1]
# eggNOG	ENOG410XRM6	LUCA
# eggNOG	KOG4403	Eukaryota
BLAST	swissprot:STIM2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:STIM2_HUMAN
BioCyc	ZFISH:ENSG00000109689-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000109689-MONOMER
COXPRESdb	57620	http://coxpresdb.jp/data/gene/57620.shtml
CleanEx	HS_STIM2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_STIM2
DOI	10.1016/j.bbrc.2007.12.129	http://dx.doi.org/10.1016/j.bbrc.2007.12.129
DOI	10.1016/j.cell.2007.11.039	http://dx.doi.org/10.1016/j.cell.2007.11.039
DOI	10.1016/j.cell.2012.01.055	http://dx.doi.org/10.1016/j.cell.2012.01.055
DOI	10.1016/j.cub.2005.05.055	http://dx.doi.org/10.1016/j.cub.2005.05.055
DOI	10.1016/j.cub.2006.05.051	http://dx.doi.org/10.1016/j.cub.2006.05.051
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/0264-6021:3570673	http://dx.doi.org/10.1042/0264-6021:3570673
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.1015125108	http://dx.doi.org/10.1073/pnas.1015125108
DOI	10.1074/jbc.C800178200	http://dx.doi.org/10.1074/jbc.C800178200
DOI	10.1093/dnares/7.2.143	http://dx.doi.org/10.1093/dnares/7.2.143
DOI	10.1096/fj.07-9449com	http://dx.doi.org/10.1096/fj.07-9449com
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1101/gr.GR1547R	http://dx.doi.org/10.1101/gr.GR1547R
DOI	10.1113/jphysiol.2012.245399	http://dx.doi.org/10.1113/jphysiol.2012.245399
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
EMBL	AB040915	http://www.ebi.ac.uk/ena/data/view/AB040915
EMBL	AF328905	http://www.ebi.ac.uk/ena/data/view/AF328905
EMBL	AK023369	http://www.ebi.ac.uk/ena/data/view/AK023369
EMBL	AL136577	http://www.ebi.ac.uk/ena/data/view/AL136577
EMBL	BC015659	http://www.ebi.ac.uk/ena/data/view/BC015659
EMBL	BC057231	http://www.ebi.ac.uk/ena/data/view/BC057231
EMBL	BC136449	http://www.ebi.ac.uk/ena/data/view/BC136449
EMBL	BC146661	http://www.ebi.ac.uk/ena/data/view/BC146661
EMBL	BC152554	http://www.ebi.ac.uk/ena/data/view/BC152554
EMBL	BC171766	http://www.ebi.ac.uk/ena/data/view/BC171766
Ensembl	ENST00000412829	http://www.ensembl.org/id/ENST00000412829
Ensembl	ENST00000467087	http://www.ensembl.org/id/ENST00000467087
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005246	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005246
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0015279	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015279
GO_process	GO:0002115	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002115
GO_process	GO:0006874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874
GO_process	GO:0032237	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032237
GO_process	GO:0051928	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051928
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
Gene3D	1.10.150.50	http://www.cathdb.info/version/latest/superfamily/1.10.150.50
GeneCards	STIM2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=STIM2
GeneID	57620	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57620
HGNC	HGNC:19205	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:19205
HOGENOM	HOG000261647	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261647&db=HOGENOM6
HOVERGEN	HBG079219	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG079219&db=HOVERGEN
HPA	CAB037196	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB037196
HPA	HPA036933	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA036933
HPA	HPA057511	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA057511
InParanoid	Q9P246	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9P246
IntAct	Q9P246	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9P246*
InterPro	IPR001660	http://www.ebi.ac.uk/interpro/entry/IPR001660
InterPro	IPR013761	http://www.ebi.ac.uk/interpro/entry/IPR013761
InterPro	IPR032393	http://www.ebi.ac.uk/interpro/entry/IPR032393
Jabion	57620	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=57620
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Gene	hsa:57620	http://www.genome.jp/dbget-bin/www_bget?hsa:57620
KEGG_Orthology	KO:K16059	http://www.genome.jp/dbget-bin/www_bget?KO:K16059
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
MIM	610841	http://www.ncbi.nlm.nih.gov/omim/610841
MINT	MINT-1195661	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1195661
PDB	2L5Y	http://www.ebi.ac.uk/pdbe-srv/view/entry/2L5Y
PDBsum	2L5Y	http://www.ebi.ac.uk/pdbsum/2L5Y
PROSITE	PS50105	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50105
PSORT	swissprot:STIM2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:STIM2_HUMAN
PSORT-B	swissprot:STIM2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:STIM2_HUMAN
PSORT2	swissprot:STIM2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:STIM2_HUMAN
Pfam	PF07647	http://pfam.xfam.org/family/PF07647
Pfam	PF16533	http://pfam.xfam.org/family/PF16533
PharmGKB	PA134926985	http://www.pharmgkb.org/do/serve?objId=PA134926985&objCls=Gene
Phobius	swissprot:STIM2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:STIM2_HUMAN
PhylomeDB	Q9P246	http://phylomedb.org/?seqid=Q9P246
ProteinModelPortal	Q9P246	http://www.proteinmodelportal.org/query/uniprot/Q9P246
PubMed	10819331	http://www.ncbi.nlm.nih.gov/pubmed/10819331
PubMed	11230166	http://www.ncbi.nlm.nih.gov/pubmed/11230166
PubMed	11463338	http://www.ncbi.nlm.nih.gov/pubmed/11463338
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16005298	http://www.ncbi.nlm.nih.gov/pubmed/16005298
PubMed	16860747	http://www.ncbi.nlm.nih.gov/pubmed/16860747
PubMed	17905723	http://www.ncbi.nlm.nih.gov/pubmed/17905723
PubMed	18160041	http://www.ncbi.nlm.nih.gov/pubmed/18160041
PubMed	18166150	http://www.ncbi.nlm.nih.gov/pubmed/18166150
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19019825	http://www.ncbi.nlm.nih.gov/pubmed/19019825
PubMed	21217057	http://www.ncbi.nlm.nih.gov/pubmed/21217057
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	22464749	http://www.ncbi.nlm.nih.gov/pubmed/22464749
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	23359669	http://www.ncbi.nlm.nih.gov/pubmed/23359669
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
RefSeq	NP_001162588	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001162588
RefSeq	NP_001162589	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001162589
RefSeq	NP_065911	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_065911
SMR	Q9P246	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9P246
STRING	9606.ENSP00000417569	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000417569&targetmode=cogs
SUPFAM	SSF47769	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47769
TCDB	1.A.52.1	http://www.tcdb.org/search/result.php?tc=1.A.52.1
UCSC	uc003gsg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003gsg&org=rat
UniGene	Hs.744950	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.744950
UniProtKB	STIM2_HUMAN	http://www.uniprot.org/uniprot/STIM2_HUMAN
UniProtKB-AC	Q9P246	http://www.uniprot.org/uniprot/Q9P246
charge	swissprot:STIM2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:STIM2_HUMAN
eggNOG	ENOG410XRM6	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRM6
eggNOG	KOG4403	http://eggnogapi.embl.de/nog_data/html/tree/KOG4403
epestfind	swissprot:STIM2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:STIM2_HUMAN
garnier	swissprot:STIM2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:STIM2_HUMAN
helixturnhelix	swissprot:STIM2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:STIM2_HUMAN
hmoment	swissprot:STIM2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:STIM2_HUMAN
iep	swissprot:STIM2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:STIM2_HUMAN
inforesidue	swissprot:STIM2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:STIM2_HUMAN
neXtProt	NX_Q9P246	http://www.nextprot.org/db/entry/NX_Q9P246
octanol	swissprot:STIM2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:STIM2_HUMAN
pepcoil	swissprot:STIM2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:STIM2_HUMAN
pepdigest	swissprot:STIM2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:STIM2_HUMAN
pepinfo	swissprot:STIM2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:STIM2_HUMAN
pepnet	swissprot:STIM2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:STIM2_HUMAN
pepstats	swissprot:STIM2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:STIM2_HUMAN
pepwheel	swissprot:STIM2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:STIM2_HUMAN
pepwindow	swissprot:STIM2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:STIM2_HUMAN
sigcleave	swissprot:STIM2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:STIM2_HUMAN
## Database	ID	URL or Descriptions
# AltName	UCRI_HUMAN	Complex III subunit 5
# AltName	UCRI_HUMAN	Complex III subunit IX
# AltName	UCRI_HUMAN	Cytochrome b-c1 complex subunit 5
# AltName	UCRI_HUMAN	Rieske iron-sulfur protein
# AltName	UCRI_HUMAN	Ubiquinol-cytochrome c reductase 8 kDa protein
# AltName	UCRI_HUMAN	Ubiquinol-cytochrome c reductase iron-sulfur subunit
# AltName	UCRI_HUMAN	Ubiquinol-cytochrome c reductase iron-sulfur subunit
# BioGrid	113232	77
# CATALYTIC ACTIVITY	UCRI_HUMAN	Quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H(+). 
# COFACTOR	UCRI_HUMAN	Name=[2Fe-2S] cluster; Xref=ChEBI CHEBI 49601; Evidence={ECO 0000255|PROSITE-ProRule PRU00628}; Note=Binds 1 [2Fe-2S] cluster per subunit. {ECO 0000255|PROSITE- ProRule PRU00628}; 
# ChiTaRS	UQCRFS1	human
# Ensembl	ENST00000304863	ENSP00000306397; ENSG00000169021
# FUNCTION	UCRI_HUMAN	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. 
# FUNCTION	UCRI_HUMAN	The transit peptide of the Rieske protein seems to form part of the bc1 complex and is considered to be the subunit 11/IX of that complex. {ECO 0000250}. 
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0005750	mitochondrial respiratory chain complex III; IEA:Ensembl.
# GO_component	GO:0043209	myelin sheath; IEA:Ensembl.
# GO_function	GO:0008121	ubiquinol-cytochrome-c reductase activity; IEA:UniProtKB-EC.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_function	GO:0051537	2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
# GO_process	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c; TAS:Reactome.
# GO_process	GO:0009725	response to hormone; IEA:Ensembl.
# GO_process	GO:0042493	response to drug; IEA:Ensembl.
# GO_process	GO:0046677	response to antibiotic; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.20.5.270	-; 1.
# Gene3D	2.102.10.10	-; 1.
# Genevisible	P47985	HS
# HGNC	HGNC:12587	UQCRFS1
# IntAct	P47985	16
# InterPro	IPR004192	Ubiquinol_cyt_Rdtase_TM
# InterPro	IPR005805	Rieske_Fe-S_prot_C
# InterPro	IPR006317	Ubiquinol_cyt_c_Rdtase_Fe-S-su
# InterPro	IPR011070	Globular_prot_asu/bsu
# InterPro	IPR014349	Rieske_Fe-S_prot
# InterPro	IPR015248	Ubiqinol_cyt_c_Rdtase_N
# InterPro	IPR017941	Rieske_2Fe-2S
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko00910	Nitrogen metabolism
# KEGG_Pathway	ko02020	Two-component system
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	191327	gene
# MISCELLANEOUS	UCRI_HUMAN	The Rieske protein is a high potential 2Fe-2S protein. 
# Organism	UCRI_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10134	PTHR10134
# PRINTS	PR00162	RIESKE
# PROSITE	PS51296	RIESKE
# Pfam	PF00355	Rieske
# Pfam	PF02921	UCR_TM
# Pfam	PF09165	Ubiq-Cytc-red_N
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-611105	Respiratory electron transport
# RecName	UCRI_HUMAN	Cytochrome b-c1 complex subunit 11
# RecName	UCRI_HUMAN	Cytochrome b-c1 complex subunit Rieske, mitochondrial
# RefSeq	NP_005994	NM_006003.2
# SIMILARITY	Contains 1 Rieske domain. {ECO:0000255|PROSITE- ProRule	PRU00628}.
# SUBCELLULAR LOCATION	UCRI_HUMAN	Mitochondrion inner membrane; Single-pass membrane protein. 
# SUBUNIT	The bc1 complex contains 11 subunits	 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1). 
# SUPFAM	SSF50022	SSF50022
# SUPFAM	SSF56568	SSF56568
# TIGRFAMs	TIGR01416	Rieske_proteo
# UCSC	uc002nsd	human
# eggNOG	COG0723	LUCA
# eggNOG	KOG1671	Eukaryota
BLAST	swissprot:UCRI_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:UCRI_HUMAN
BioCyc	ZFISH:HS09867-MONOMER	http://biocyc.org/getid?id=ZFISH:HS09867-MONOMER
COG	COG0723	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0723
COXPRESdb	7386	http://coxpresdb.jp/data/gene/7386.shtml
CleanEx	HS_UQCRFS1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_UQCRFS1
DOI	10.1002/elps.1150180343	http://dx.doi.org/10.1002/elps.1150180343
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/0378-1119(94)00683-J	http://dx.doi.org/10.1016/0378-1119(94)00683-J
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EC_number	EC:1.10.2.2	http://www.genome.jp/dbget-bin/www_bget?EC:1.10.2.2
EMBL	AC007786	http://www.ebi.ac.uk/ena/data/view/AC007786
EMBL	AK291134	http://www.ebi.ac.uk/ena/data/view/AK291134
EMBL	BC000649	http://www.ebi.ac.uk/ena/data/view/BC000649
EMBL	BC010035	http://www.ebi.ac.uk/ena/data/view/BC010035
EMBL	BC067832	http://www.ebi.ac.uk/ena/data/view/BC067832
EMBL	L32917	http://www.ebi.ac.uk/ena/data/view/L32917
EMBL	L32977	http://www.ebi.ac.uk/ena/data/view/L32977
ENZYME	1.10.2.2	http://enzyme.expasy.org/EC/1.10.2.2
Ensembl	ENST00000304863	http://www.ensembl.org/id/ENST00000304863
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005750	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005750
GO_component	GO:0043209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043209
GO_function	GO:0008121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008121
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_function	GO:0051537	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537
GO_process	GO:0006122	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006122
GO_process	GO:0009725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009725
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0046677	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.20.5.270	http://www.cathdb.info/version/latest/superfamily/1.20.5.270
Gene3D	2.102.10.10	http://www.cathdb.info/version/latest/superfamily/2.102.10.10
GeneCards	UQCRFS1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=UQCRFS1
GeneID	7386	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7386
GeneTree	ENSGT00390000001014	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000001014
H-InvDB	HIX0041192	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0041192
HGNC	HGNC:12587	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:12587
HOVERGEN	HBG001040	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG001040&db=HOVERGEN
HPA	HPA041863	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA041863
HPA	HPA050339	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA050339
InParanoid	P47985	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P47985
IntAct	P47985	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P47985*
IntEnz	1.10.2.2	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.10.2.2
InterPro	IPR004192	http://www.ebi.ac.uk/interpro/entry/IPR004192
InterPro	IPR005805	http://www.ebi.ac.uk/interpro/entry/IPR005805
InterPro	IPR006317	http://www.ebi.ac.uk/interpro/entry/IPR006317
InterPro	IPR011070	http://www.ebi.ac.uk/interpro/entry/IPR011070
InterPro	IPR014349	http://www.ebi.ac.uk/interpro/entry/IPR014349
InterPro	IPR015248	http://www.ebi.ac.uk/interpro/entry/IPR015248
InterPro	IPR017941	http://www.ebi.ac.uk/interpro/entry/IPR017941
Jabion	7386	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7386
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:7386	http://www.genome.jp/dbget-bin/www_bget?hsa:7386
KEGG_Orthology	KO:K00411	http://www.genome.jp/dbget-bin/www_bget?KO:K00411
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko00910	http://www.genome.jp/kegg-bin/show_pathway?ko00910
KEGG_Pathway	ko02020	http://www.genome.jp/kegg-bin/show_pathway?ko02020
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	191327	http://www.ncbi.nlm.nih.gov/omim/191327
MINT	MINT-2803370	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-2803370
OMA	PFYEFPD	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PFYEFPD
OrthoDB	EOG091G0MOP	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0MOP
PANTHER	PTHR10134	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10134
PRINTS	PR00162	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00162
PROSITE	PS51296	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51296
PSORT	swissprot:UCRI_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:UCRI_HUMAN
PSORT-B	swissprot:UCRI_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:UCRI_HUMAN
PSORT2	swissprot:UCRI_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:UCRI_HUMAN
Pfam	PF00355	http://pfam.xfam.org/family/PF00355
Pfam	PF02921	http://pfam.xfam.org/family/PF02921
Pfam	PF09165	http://pfam.xfam.org/family/PF09165
PharmGKB	PA37218	http://www.pharmgkb.org/do/serve?objId=PA37218&objCls=Gene
Phobius	swissprot:UCRI_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:UCRI_HUMAN
PhylomeDB	P47985	http://phylomedb.org/?seqid=P47985
ProteinModelPortal	P47985	http://www.proteinmodelportal.org/query/uniprot/P47985
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	2158323	http://www.ncbi.nlm.nih.gov/pubmed/2158323
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	7721092	http://www.ncbi.nlm.nih.gov/pubmed/7721092
PubMed	9150947	http://www.ncbi.nlm.nih.gov/pubmed/9150947
Reactome	R-HSA-611105	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-611105
RefSeq	NP_005994	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005994
SMR	P47985	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P47985
STRING	9606.ENSP00000306397	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000306397&targetmode=cogs
STRING	COG0723	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0723&targetmode=cogs
SUPFAM	SSF50022	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50022
SUPFAM	SSF56568	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56568
SWISS-2DPAGE	P47985	http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P47985
TIGRFAMs	TIGR01416	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01416
UCSC	uc002nsd	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002nsd&org=rat
UniGene	Hs.743307	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.743307
UniProtKB	UCRI_HUMAN	http://www.uniprot.org/uniprot/UCRI_HUMAN
UniProtKB-AC	P47985	http://www.uniprot.org/uniprot/P47985
charge	swissprot:UCRI_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:UCRI_HUMAN
eggNOG	COG0723	http://eggnogapi.embl.de/nog_data/html/tree/COG0723
eggNOG	KOG1671	http://eggnogapi.embl.de/nog_data/html/tree/KOG1671
epestfind	swissprot:UCRI_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:UCRI_HUMAN
garnier	swissprot:UCRI_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:UCRI_HUMAN
helixturnhelix	swissprot:UCRI_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:UCRI_HUMAN
hmoment	swissprot:UCRI_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:UCRI_HUMAN
iep	swissprot:UCRI_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:UCRI_HUMAN
inforesidue	swissprot:UCRI_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:UCRI_HUMAN
neXtProt	NX_P47985	http://www.nextprot.org/db/entry/NX_P47985
octanol	swissprot:UCRI_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:UCRI_HUMAN
pepcoil	swissprot:UCRI_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:UCRI_HUMAN
pepdigest	swissprot:UCRI_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:UCRI_HUMAN
pepinfo	swissprot:UCRI_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:UCRI_HUMAN
pepnet	swissprot:UCRI_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:UCRI_HUMAN
pepstats	swissprot:UCRI_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:UCRI_HUMAN
pepwheel	swissprot:UCRI_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:UCRI_HUMAN
pepwindow	swissprot:UCRI_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:UCRI_HUMAN
sigcleave	swissprot:UCRI_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:UCRI_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCMB1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q16558-1; Sequence=Displayed; Name=2; IsoId=Q16558-2; Sequence=VSP_009822, VSP_009823; Note=No experimental confirmation available.; 
# AltName	KCMB1_HUMAN	BK channel subunit beta-1
# AltName	KCMB1_HUMAN	Calcium-activated potassium channel, subfamily M subunit beta-1
# AltName	KCMB1_HUMAN	Charybdotoxin receptor subunit beta-1
# AltName	KCMB1_HUMAN	K(VCA)beta-1
# AltName	KCMB1_HUMAN	Maxi K channel subunit beta-1
# AltName	KCMB1_HUMAN	Slo-beta-1
# BioGrid	109980	4
# CCDS	CCDS4373	-. [Q16558-1]
# DrugBank	DB00721	Procaine
# DrugBank	DB01110	Miconazole
# Ensembl	ENST00000274629	ENSP00000274629; ENSG00000145936. [Q16558-1]
# Ensembl	ENST00000521859	ENSP00000427940; ENSG00000145936. [Q16558-2]
# FUNCTION	KCMB1_HUMAN	Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IBA:GO_Central.
# GO_function	GO:0015269	calcium-activated potassium channel activity; TAS:ProtInc.
# GO_function	GO:0015459	potassium channel regulator activity; TAS:ProtInc.
# GO_process	GO:0005513	detection of calcium ion; IBA:GO_Central.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:ProtInc.
# GO_process	GO:0007568	aging; IEA:Ensembl.
# GO_process	GO:0045909	positive regulation of vasodilation; IEA:Ensembl.
# GO_process	GO:0071361	cellular response to ethanol; IEA:Ensembl.
# GO_process	GO:0071456	cellular response to hypoxia; IEA:Ensembl.
# GO_process	GO:1901381	positive regulation of potassium ion transmembrane transport; IEA:Ensembl.
# GO_process	GO:1903413	cellular response to bile acid; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0003013	circulatory system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0007568	aging
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q16558	HS
# HGNC	HGNC:6285	KCNMB1
# InterPro	IPR003930	K_chnl_Ca-activ_BK_bsu
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04270	Vascular smooth muscle contraction
# MIM	603951	gene
# MIM	608622	phenotype
# Organism	KCMB1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10258	PTHR10258
# PIR	S68842	S68842
# POLYMORPHISM	Genetic variation in KCNMB1 can influence the severity of diastolic hypertension (PubMed:15057310). {ECO	0000269|PubMed:15057310}. 
# PRINTS	PR01450	BKCHANNELB
# PTM	KCMB1_HUMAN	N-glycosylated. {ECO 0000269|PubMed 10792058}. 
# Pfam	PF03185	CaKB
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-1296052	Ca2+ activated K+ channels
# Reactome	R-HSA-418457	cGMP effects
# RecName	KCMB1_HUMAN	Calcium-activated potassium channel subunit beta-1
# RefSeq	NP_004128	NM_004137.3. [Q16558-1]
# SIMILARITY	Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB1 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCMB1_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	KCMB1_HUMAN	Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB1 per KCNMA1 tetramer. 
# TCDB	8.A.14.1	the ca(2+)-activated k(+) channel auxiliary subunit slowpoke-Beta (sloBeta) family
# TISSUE SPECIFICITY	KCMB1_HUMAN	Abundantly expressed in smooth muscle. Low levels of expression in most other tissues. Within the brain, relatively high levels found in hippocampus and corpus callosum. 
# UCSC	uc003maq	human. [Q16558-1]
# eggNOG	ENOG410IWME	Eukaryota
# eggNOG	ENOG41116AX	LUCA
BLAST	swissprot:KCMB1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCMB1_HUMAN
BioCyc	ZFISH:ENSG00000145936-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000145936-MONOMER
COXPRESdb	3779	http://coxpresdb.jp/data/gene/3779.shtml
CleanEx	HS_KCNMB1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNMB1
DOI	10.1016/0014-5793(96)00151-2	http://dx.doi.org/10.1016/0014-5793(96)00151-2
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.100118597	http://dx.doi.org/10.1073/pnas.100118597
DOI	10.1073/pnas.93.17.9200	http://dx.doi.org/10.1073/pnas.93.17.9200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.285.5435.1929	http://dx.doi.org/10.1126/science.285.5435.1929
DOI	10.1152/nips.01387.2002	http://dx.doi.org/10.1152/nips.01387.2002
DOI	10.1172/JCI200420347	http://dx.doi.org/10.1172/JCI200420347
DrugBank	DB00721	http://www.drugbank.ca/drugs/DB00721
DrugBank	DB01110	http://www.drugbank.ca/drugs/DB01110
EMBL	AF026002	http://www.ebi.ac.uk/ena/data/view/AF026002
EMBL	AK313979	http://www.ebi.ac.uk/ena/data/view/AK313979
EMBL	AY044441	http://www.ebi.ac.uk/ena/data/view/AY044441
EMBL	AY515264	http://www.ebi.ac.uk/ena/data/view/AY515264
EMBL	BC025707	http://www.ebi.ac.uk/ena/data/view/BC025707
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	U25138	http://www.ebi.ac.uk/ena/data/view/U25138
EMBL	U38907	http://www.ebi.ac.uk/ena/data/view/U38907
EMBL	U42600	http://www.ebi.ac.uk/ena/data/view/U42600
EMBL	U42601	http://www.ebi.ac.uk/ena/data/view/U42601
EMBL	U42602	http://www.ebi.ac.uk/ena/data/view/U42602
EMBL	U42603	http://www.ebi.ac.uk/ena/data/view/U42603
EMBL	U61536	http://www.ebi.ac.uk/ena/data/view/U61536
EMBL	U61537	http://www.ebi.ac.uk/ena/data/view/U61537
Ensembl	ENST00000274629	http://www.ensembl.org/id/ENST00000274629
Ensembl	ENST00000521859	http://www.ensembl.org/id/ENST00000521859
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_function	GO:0015269	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015269
GO_function	GO:0015459	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015459
GO_process	GO:0005513	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005513
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007568	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007568
GO_process	GO:0045909	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045909
GO_process	GO:0071361	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071361
GO_process	GO:0071456	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071456
GO_process	GO:1901381	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901381
GO_process	GO:1903413	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903413
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0003013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003013
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0007568	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007568
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	KCNMB1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNMB1
GeneID	3779	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3779
GeneTree	ENSGT00390000015997	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000015997
HGNC	HGNC:6285	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6285
HOVERGEN	HBG052223	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052223&db=HOVERGEN
HPA	HPA020435	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA020435
InParanoid	Q16558	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q16558
IntAct	Q16558	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q16558*
InterPro	IPR003930	http://www.ebi.ac.uk/interpro/entry/IPR003930
Jabion	3779	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3779
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3779	http://www.genome.jp/dbget-bin/www_bget?hsa:3779
KEGG_Orthology	KO:K04937	http://www.genome.jp/dbget-bin/www_bget?KO:K04937
KEGG_Pathway	ko04270	http://www.genome.jp/kegg-bin/show_pathway?ko04270
MIM	603951	http://www.ncbi.nlm.nih.gov/omim/603951
MIM	608622	http://www.ncbi.nlm.nih.gov/omim/608622
MINT	MINT-1470084	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1470084
OMA	AMLYHTE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AMLYHTE
OrthoDB	EOG091G0MVO	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0MVO
PANTHER	PTHR10258	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10258
PRINTS	PR01450	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01450
PSORT	swissprot:KCMB1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCMB1_HUMAN
PSORT-B	swissprot:KCMB1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCMB1_HUMAN
PSORT2	swissprot:KCMB1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCMB1_HUMAN
Pfam	PF03185	http://pfam.xfam.org/family/PF03185
PharmGKB	PA221	http://www.pharmgkb.org/do/serve?objId=PA221&objCls=Gene
Phobius	swissprot:KCMB1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCMB1_HUMAN
PhylomeDB	Q16558	http://phylomedb.org/?seqid=Q16558
ProteinModelPortal	Q16558	http://www.proteinmodelportal.org/query/uniprot/Q16558
PubMed	10489376	http://www.ncbi.nlm.nih.gov/pubmed/10489376
PubMed	10792058	http://www.ncbi.nlm.nih.gov/pubmed/10792058
PubMed	12136044	http://www.ncbi.nlm.nih.gov/pubmed/12136044
PubMed	12434576	http://www.ncbi.nlm.nih.gov/pubmed/12434576
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15057310	http://www.ncbi.nlm.nih.gov/pubmed/15057310
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	8612769	http://www.ncbi.nlm.nih.gov/pubmed/8612769
PubMed	8764643	http://www.ncbi.nlm.nih.gov/pubmed/8764643
PubMed	8799178	http://www.ncbi.nlm.nih.gov/pubmed/8799178
Reactome	R-HSA-1296052	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296052
Reactome	R-HSA-418457	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418457
RefSeq	NP_004128	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004128
STRING	9606.ENSP00000274629	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000274629&targetmode=cogs
TCDB	8.A.14.1	http://www.tcdb.org/search/result.php?tc=8.A.14.1
UCSC	uc003maq	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003maq&org=rat
UniGene	Hs.484099	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.484099
UniGene	Hs.744947	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.744947
UniProtKB	KCMB1_HUMAN	http://www.uniprot.org/uniprot/KCMB1_HUMAN
UniProtKB-AC	Q16558	http://www.uniprot.org/uniprot/Q16558
charge	swissprot:KCMB1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCMB1_HUMAN
eggNOG	ENOG410IWME	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IWME
eggNOG	ENOG41116AX	http://eggnogapi.embl.de/nog_data/html/tree/ENOG41116AX
epestfind	swissprot:KCMB1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCMB1_HUMAN
garnier	swissprot:KCMB1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCMB1_HUMAN
helixturnhelix	swissprot:KCMB1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCMB1_HUMAN
hmoment	swissprot:KCMB1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCMB1_HUMAN
iep	swissprot:KCMB1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCMB1_HUMAN
inforesidue	swissprot:KCMB1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCMB1_HUMAN
neXtProt	NX_Q16558	http://www.nextprot.org/db/entry/NX_Q16558
octanol	swissprot:KCMB1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCMB1_HUMAN
pepcoil	swissprot:KCMB1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCMB1_HUMAN
pepdigest	swissprot:KCMB1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCMB1_HUMAN
pepinfo	swissprot:KCMB1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCMB1_HUMAN
pepnet	swissprot:KCMB1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCMB1_HUMAN
pepstats	swissprot:KCMB1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCMB1_HUMAN
pepwheel	swissprot:KCMB1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCMB1_HUMAN
pepwindow	swissprot:KCMB1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCMB1_HUMAN
sigcleave	swissprot:KCMB1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCMB1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=3; Name=2; Synonyms=CLIC5B; IsoId=Q9NZA1-1; Sequence=Displayed; Name=1; Synonyms=CLIC5A; IsoId=Q9NZA1-2; Sequence=VSP_000869, VSP_000870; Note=Ref.1 (AAF66928) sequence is in conflict in position: 12	R->S. {ECO:0000305}; Name=3; IsoId=Q9NZA1-3; Sequence=VSP_044889, VSP_044890, VSP_044891; Note=No experimental confirmation available.; 
# BioGrid	119781	7
# CCDS	CCDS47438	-. [Q9NZA1-1]
# CCDS	CCDS4914	-. [Q9NZA1-2]
# CCDS	CCDS59022	-. [Q9NZA1-3]
# ChiTaRS	CLIC5	human
# DISEASE	CLIC5_HUMAN	Deafness, autosomal recessive, 103 (DFNB103) [MIM 616042]  A form of sensorineural deafness with onset in early childhood. Hearing impairment progresses from mild to severe or even profound before the second decade, and is accompanied by vestibular areflexia. {ECO 0000269|PubMed 24781754}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	CLIC5_HUMAN	Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity). {ECO 0000250}. 
# Ensembl	ENST00000185206	ENSP00000185206; ENSG00000112782. [Q9NZA1-1]
# Ensembl	ENST00000339561	ENSP00000344165; ENSG00000112782. [Q9NZA1-2]
# Ensembl	ENST00000544153	ENSP00000439195; ENSG00000112782. [Q9NZA1-3]
# ExpressionAtlas	Q9NZA1	baseline and differential
# FUNCTION	CLIC5_HUMAN	Required for normal hearing (PubMed 24781754). It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti (By similarity). Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture (PubMed 15184393, PubMed 18028448, PubMed 20335315). {ECO 0000250|UniProtKB Q8BXK9, ECO 0000269|PubMed 15184393, ECO 0000269|PubMed 18028448, ECO 0000269|PubMed 20335315, ECO 0000269|PubMed 24781754}. 
# GO_component	GO:0005794	Golgi apparatus; IDA:UniProtKB.
# GO_component	GO:0005815	microtubule organizing center; IEA:UniProtKB-SubCell.
# GO_component	GO:0005938	cell cortex; IEA:UniProtKB-SubCell.
# GO_component	GO:0015629	actin cytoskeleton; IDA:UniProtKB.
# GO_component	GO:0032420	stereocilium; IEA:Ensembl.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005244	voltage-gated ion channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0005254	chloride channel activity; IBA:GO_Central.
# GO_process	GO:0002024	diet induced thermogenesis; IEA:Ensembl.
# GO_process	GO:0006810	transport; NAS:ProtInc.
# GO_process	GO:0006821	chloride transport; IDA:UniProtKB.
# GO_process	GO:0007565	female pregnancy; TAS:ProtInc.
# GO_process	GO:0007605	sensory perception of sound; IMP:UniProtKB.
# GO_process	GO:0008104	protein localization; IEA:Ensembl.
# GO_process	GO:0050885	neuromuscular process controlling balance; IEA:Ensembl.
# GO_process	GO:0060088	auditory receptor cell stereocilium organization; IBA:GO_Central.
# GO_process	GO:1902476	chloride transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005815	microtubule organizing center
# GOslim_component	GO:0005856	cytoskeleton
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.1050.10	-; 1.
# Gene3D	3.40.30.10	-; 1.
# Genevisible	Q9NZA1	HS
# HGNC	HGNC:13517	CLIC5
# INTERACTION	CLIC5_HUMAN	P00523 SRC (xeno); NbExp=2; IntAct=EBI-5658997, EBI-848039; 
# IntAct	Q9NZA1	6
# InterPro	IPR002946	CLIC
# InterPro	IPR004045	Glutathione_S-Trfase_N
# InterPro	IPR010987	Glutathione-S-Trfase_C-like
# InterPro	IPR012336	Thioredoxin-like_fold
# InterPro	IPR030264	CLIC-5
# KEGG_Brite	ko04040	Ion channels
# MIM	607293	gene
# MIM	616042	phenotype
# Organism	CLIC5_HUMAN	Homo sapiens (Human)
# Orphanet	90636	Autosomal recessive non-syndromic sensorineural deafness type DFNB
# PANTHER	PTHR11260:SF152	PTHR11260:SF152; 2
# PRINTS	PR01263	INTCLCHANNEL
# PROSITE	PS50405	GST_CTER
# Pfam	PF13417	GST_N_3
# Proteomes	UP000005640	Chromosome 6
# RecName	CLIC5_HUMAN	Chloride intracellular channel protein 5
# RefSeq	NP_001107558	NM_001114086.1. [Q9NZA1-1]
# RefSeq	NP_001242952	NM_001256023.1. [Q9NZA1-3]
# RefSeq	NP_058625	NM_016929.4. [Q9NZA1-2]
# RefSeq	XP_016866442	XM_017010953.1. [Q9NZA1-1]
# SIMILARITY	Belongs to the chloride channel CLIC family. {ECO	0000305}. 
# SIMILARITY	Contains 1 GST C-terminal domain. {ECO	0000305}.
# SUBCELLULAR LOCATION	CLIC5_HUMAN	Isoform 1  Cytoplasm, cell cortex {ECO 0000269|PubMed 15184393}. Cytoplasm, cytoskeleton {ECO 0000269|PubMed 15184393}. Membrane {ECO 0000269|PubMed 15184393}; Single-pass membrane protein {ECO 0000269|PubMed 15184393}. Note=Associates with the cortical actin cytoskeleton. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity). {ECO 0000250}. 
# SUBCELLULAR LOCATION	CLIC5_HUMAN	Isoform 2  Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Membrane; Single-pass membrane protein. Note=Colocalized with AKAP9 at the Golgi apparatus as well as, to a lesser extent, the centrosome. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity). Colocalized with podocalyxin in renal glomeruli. {ECO 0000250}. 
# SUBUNIT	CLIC5_HUMAN	Component of a multimeric complex consisting of several cytoskeletal proteins, including actin, ezrin, alpha-actinin, gelsolin, and IQGAP1. Interacts with AKAP9. {ECO 0000269|PubMed 12163479, ECO 0000269|PubMed 18028448}. 
# SUPFAM	SSF47616	SSF47616
# SUPFAM	SSF52833	SSF52833
# TIGRFAMs	TIGR00862	O-ClC
# TISSUE SPECIFICITY	CLIC5_HUMAN	Widely expressed in both fetal and adult human tissues (PubMed 24781754). Isoform 1 is expressed in renal glomeruli endothelial cells and podocytes (at protein level). {ECO 0000269|PubMed 20335315, ECO 0000269|PubMed 24781754}. 
# UCSC	uc003oxu	human. [Q9NZA1-1]
# eggNOG	ENOG410ZRK6	LUCA
# eggNOG	KOG1422	Eukaryota
BLAST	swissprot:CLIC5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CLIC5_HUMAN
BioCyc	ZFISH:ENSG00000112782-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000112782-MONOMER
COXPRESdb	53405	http://coxpresdb.jp/data/gene/53405.shtml
CleanEx	HS_CLIC5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CLIC5
DOI	10.1038/ejhg.2014.83	http://dx.doi.org/10.1038/ejhg.2014.83
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M112277200	http://dx.doi.org/10.1074/jbc.M112277200
DOI	10.1074/jbc.M402835200	http://dx.doi.org/10.1074/jbc.M402835200
DOI	10.1091/mbc.11.5.1509	http://dx.doi.org/10.1091/mbc.11.5.1509
DOI	10.1093/dnares/12.2.117	http://dx.doi.org/10.1093/dnares/12.2.117
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1742-4658.2007.06145.x	http://dx.doi.org/10.1111/j.1742-4658.2007.06145.x
DOI	10.1152/ajprenal.00030.2010	http://dx.doi.org/10.1152/ajprenal.00030.2010
EMBL	AF216941	http://www.ebi.ac.uk/ena/data/view/AF216941
EMBL	AK075144	http://www.ebi.ac.uk/ena/data/view/AK075144
EMBL	AK075163	http://www.ebi.ac.uk/ena/data/view/AK075163
EMBL	AK097048	http://www.ebi.ac.uk/ena/data/view/AK097048
EMBL	AL050336	http://www.ebi.ac.uk/ena/data/view/AL050336
EMBL	AL050336	http://www.ebi.ac.uk/ena/data/view/AL050336
EMBL	AL355522	http://www.ebi.ac.uk/ena/data/view/AL355522
EMBL	AL357057	http://www.ebi.ac.uk/ena/data/view/AL357057
EMBL	AL357057	http://www.ebi.ac.uk/ena/data/view/AL357057
EMBL	AL591211	http://www.ebi.ac.uk/ena/data/view/AL591211
EMBL	AY032602	http://www.ebi.ac.uk/ena/data/view/AY032602
EMBL	BC035968	http://www.ebi.ac.uk/ena/data/view/BC035968
EMBL	CH471081	http://www.ebi.ac.uk/ena/data/view/CH471081
EMBL	CH471081	http://www.ebi.ac.uk/ena/data/view/CH471081
Ensembl	ENST00000185206	http://www.ensembl.org/id/ENST00000185206
Ensembl	ENST00000339561	http://www.ensembl.org/id/ENST00000339561
Ensembl	ENST00000544153	http://www.ensembl.org/id/ENST00000544153
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005815	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005815
GO_component	GO:0005938	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005938
GO_component	GO:0015629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015629
GO_component	GO:0032420	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032420
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005244
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_process	GO:0002024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002024
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006821
GO_process	GO:0007565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007565
GO_process	GO:0007605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007605
GO_process	GO:0008104	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008104
GO_process	GO:0050885	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050885
GO_process	GO:0060088	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060088
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005815	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005815
GOslim_component	GO:0005856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.1050.10	http://www.cathdb.info/version/latest/superfamily/1.20.1050.10
Gene3D	3.40.30.10	http://www.cathdb.info/version/latest/superfamily/3.40.30.10
GeneCards	CLIC5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CLIC5
GeneID	53405	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=53405
GeneTree	ENSGT00550000074477	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074477
HGNC	HGNC:13517	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13517
HOGENOM	HOG000065740	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000065740&db=HOGENOM6
HOVERGEN	HBG050995	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050995&db=HOVERGEN
InParanoid	Q9NZA1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NZA1
IntAct	Q9NZA1	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NZA1*
InterPro	IPR002946	http://www.ebi.ac.uk/interpro/entry/IPR002946
InterPro	IPR004045	http://www.ebi.ac.uk/interpro/entry/IPR004045
InterPro	IPR010987	http://www.ebi.ac.uk/interpro/entry/IPR010987
InterPro	IPR012336	http://www.ebi.ac.uk/interpro/entry/IPR012336
InterPro	IPR030264	http://www.ebi.ac.uk/interpro/entry/IPR030264
Jabion	53405	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=53405
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:53405	http://www.genome.jp/dbget-bin/www_bget?hsa:53405
KEGG_Orthology	KO:K05025	http://www.genome.jp/dbget-bin/www_bget?KO:K05025
MIM	607293	http://www.ncbi.nlm.nih.gov/omim/607293
MIM	616042	http://www.ncbi.nlm.nih.gov/omim/616042
MINT	MINT-4540449	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4540449
OMA	GAICKAG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GAICKAG
Orphanet	90636	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=90636
OrthoDB	EOG091G0IHT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0IHT
PANTHER	PTHR11260:SF152	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11260:SF152
PRINTS	PR01263	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01263
PROSITE	PS50405	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50405
PSORT	swissprot:CLIC5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CLIC5_HUMAN
PSORT-B	swissprot:CLIC5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CLIC5_HUMAN
PSORT2	swissprot:CLIC5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CLIC5_HUMAN
Pfam	PF13417	http://pfam.xfam.org/family/PF13417
PharmGKB	PA26592	http://www.pharmgkb.org/do/serve?objId=PA26592&objCls=Gene
Phobius	swissprot:CLIC5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CLIC5_HUMAN
PhylomeDB	Q9NZA1	http://phylomedb.org/?seqid=Q9NZA1
ProteinModelPortal	Q9NZA1	http://www.proteinmodelportal.org/query/uniprot/Q9NZA1
PubMed	10793131	http://www.ncbi.nlm.nih.gov/pubmed/10793131
PubMed	12163479	http://www.ncbi.nlm.nih.gov/pubmed/12163479
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15184393	http://www.ncbi.nlm.nih.gov/pubmed/15184393
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16303743	http://www.ncbi.nlm.nih.gov/pubmed/16303743
PubMed	18028448	http://www.ncbi.nlm.nih.gov/pubmed/18028448
PubMed	20335315	http://www.ncbi.nlm.nih.gov/pubmed/20335315
PubMed	24781754	http://www.ncbi.nlm.nih.gov/pubmed/24781754
RefSeq	NP_001107558	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001107558
RefSeq	NP_001242952	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001242952
RefSeq	NP_058625	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_058625
RefSeq	XP_016866442	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016866442
SMR	Q9NZA1	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9NZA1
STRING	9606.ENSP00000185206	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000185206&targetmode=cogs
SUPFAM	SSF47616	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47616
SUPFAM	SSF52833	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833
TIGRFAMs	TIGR00862	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00862
UCSC	uc003oxu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003oxu&org=rat
UniGene	Hs.485489	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.485489
UniGene	Hs.734348	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.734348
UniProtKB	CLIC5_HUMAN	http://www.uniprot.org/uniprot/CLIC5_HUMAN
UniProtKB-AC	Q9NZA1	http://www.uniprot.org/uniprot/Q9NZA1
charge	swissprot:CLIC5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CLIC5_HUMAN
eggNOG	ENOG410ZRK6	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZRK6
eggNOG	KOG1422	http://eggnogapi.embl.de/nog_data/html/tree/KOG1422
epestfind	swissprot:CLIC5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CLIC5_HUMAN
garnier	swissprot:CLIC5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CLIC5_HUMAN
helixturnhelix	swissprot:CLIC5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLIC5_HUMAN
hmoment	swissprot:CLIC5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CLIC5_HUMAN
iep	swissprot:CLIC5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CLIC5_HUMAN
inforesidue	swissprot:CLIC5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CLIC5_HUMAN
neXtProt	NX_Q9NZA1	http://www.nextprot.org/db/entry/NX_Q9NZA1
octanol	swissprot:CLIC5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CLIC5_HUMAN
pepcoil	swissprot:CLIC5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CLIC5_HUMAN
pepdigest	swissprot:CLIC5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CLIC5_HUMAN
pepinfo	swissprot:CLIC5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CLIC5_HUMAN
pepnet	swissprot:CLIC5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CLIC5_HUMAN
pepstats	swissprot:CLIC5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CLIC5_HUMAN
pepwheel	swissprot:CLIC5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CLIC5_HUMAN
pepwindow	swissprot:CLIC5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CLIC5_HUMAN
sigcleave	swissprot:CLIC5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CLIC5_HUMAN
## Database	ID	URL or Descriptions
# AltName	S22AE_HUMAN	Organic cation transporter-like 4
# CDD	cd06174	MFS
# Ensembl	ENST00000273173	ENSP00000273173; ENSG00000144671
# Ensembl	ENST00000448498	ENSP00000396283; ENSG00000144671
# ExpressionAtlas	Q9Y267	baseline and differential
# GO_component	GO:0005887	integral component of plasma membrane; NAS:UniProtKB.
# GO_function	GO:0015101	organic cation transmembrane transporter activity; NAS:UniProtKB.
# GO_function	GO:0022891	substrate-specific transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0015695	organic cation transport; NAS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q9Y267	HS
# HGNC	HGNC:8495	SLC22A14
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	604048	gene
# Organism	S22AE_HUMAN	Homo sapiens (Human)
# PROSITE	PS50850	MFS
# Pfam	PF00083	Sugar_tr
# Proteomes	UP000005640	Chromosome 3
# RecName	S22AE_HUMAN	Solute carrier family 22 member 14
# RefSeq	NP_001306962	NM_001320033.1
# RefSeq	NP_004794	NM_004803.4
# RefSeq	XP_005265642	XM_005265585.4
# RefSeq	XP_011532547	XM_011534245.2
# SIMILARITY	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S22AE_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.19.22	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	Ubiquitous. {ECO:0000269|PubMed	10072596}. 
# UCSC	uc003cib	human
# eggNOG	ENOG410IRHZ	Eukaryota
# eggNOG	ENOG410XQIT	LUCA
BLAST	swissprot:S22AE_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S22AE_HUMAN
BioCyc	ZFISH:ENSG00000144671-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000144671-MONOMER
COXPRESdb	9389	http://coxpresdb.jp/data/gene/9389.shtml
CleanEx	HS_SLC22A14	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC22A14
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/dnares/6.1.37	http://dx.doi.org/10.1093/dnares/6.1.37
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB011082	http://www.ebi.ac.uk/ena/data/view/AB011082
EMBL	AB026898	http://www.ebi.ac.uk/ena/data/view/AB026898
EMBL	AK315317	http://www.ebi.ac.uk/ena/data/view/AK315317
EMBL	AP006193	http://www.ebi.ac.uk/ena/data/view/AP006193
EMBL	BC075070	http://www.ebi.ac.uk/ena/data/view/BC075070
EMBL	BC075071	http://www.ebi.ac.uk/ena/data/view/BC075071
EMBL	BC126482	http://www.ebi.ac.uk/ena/data/view/BC126482
EMBL	BC130543	http://www.ebi.ac.uk/ena/data/view/BC130543
EMBL	CH471055	http://www.ebi.ac.uk/ena/data/view/CH471055
Ensembl	ENST00000273173	http://www.ensembl.org/id/ENST00000273173
Ensembl	ENST00000448498	http://www.ensembl.org/id/ENST00000448498
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0015101	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015101
GO_function	GO:0022891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022891
GO_process	GO:0015695	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015695
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC22A14	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC22A14
GeneID	9389	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9389
GeneTree	ENSGT00860000133730	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00860000133730
H-InvDB	HIX0024265	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0024265
HGNC	HGNC:8495	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:8495
HOGENOM	HOG000234569	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234569&db=HOGENOM6
HOVERGEN	HBG108434	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108434&db=HOVERGEN
HPA	HPA037556	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA037556
InParanoid	Q9Y267	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y267
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	9389	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9389
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:9389	http://www.genome.jp/dbget-bin/www_bget?hsa:9389
KEGG_Orthology	KO:K08210	http://www.genome.jp/dbget-bin/www_bget?KO:K08210
MIM	604048	http://www.ncbi.nlm.nih.gov/omim/604048
OMA	SAFFMFA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SAFFMFA
OrthoDB	EOG091G07EF	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07EF
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:S22AE_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S22AE_HUMAN
PSORT-B	swissprot:S22AE_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S22AE_HUMAN
PSORT2	swissprot:S22AE_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S22AE_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
PharmGKB	PA32815	http://www.pharmgkb.org/do/serve?objId=PA32815&objCls=Gene
Phobius	swissprot:S22AE_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S22AE_HUMAN
PhylomeDB	Q9Y267	http://phylomedb.org/?seqid=Q9Y267
ProteinModelPortal	Q9Y267	http://www.proteinmodelportal.org/query/uniprot/Q9Y267
PubMed	10072596	http://www.ncbi.nlm.nih.gov/pubmed/10072596
PubMed	10231028	http://www.ncbi.nlm.nih.gov/pubmed/10231028
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
RefSeq	NP_001306962	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001306962
RefSeq	NP_004794	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004794
RefSeq	XP_005265642	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005265642
RefSeq	XP_011532547	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011532547
STRING	9606.ENSP00000273173	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000273173&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.19.22	http://www.tcdb.org/search/result.php?tc=2.A.1.19.22
UCSC	uc003cib	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003cib&org=rat
UniGene	Hs.165559	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.165559
UniProtKB	S22AE_HUMAN	http://www.uniprot.org/uniprot/S22AE_HUMAN
UniProtKB-AC	Q9Y267	http://www.uniprot.org/uniprot/Q9Y267
charge	swissprot:S22AE_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S22AE_HUMAN
eggNOG	ENOG410IRHZ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IRHZ
eggNOG	ENOG410XQIT	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQIT
epestfind	swissprot:S22AE_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S22AE_HUMAN
garnier	swissprot:S22AE_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S22AE_HUMAN
helixturnhelix	swissprot:S22AE_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S22AE_HUMAN
hmoment	swissprot:S22AE_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S22AE_HUMAN
iep	swissprot:S22AE_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S22AE_HUMAN
inforesidue	swissprot:S22AE_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S22AE_HUMAN
neXtProt	NX_Q9Y267	http://www.nextprot.org/db/entry/NX_Q9Y267
octanol	swissprot:S22AE_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S22AE_HUMAN
pepcoil	swissprot:S22AE_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S22AE_HUMAN
pepdigest	swissprot:S22AE_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S22AE_HUMAN
pepinfo	swissprot:S22AE_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S22AE_HUMAN
pepnet	swissprot:S22AE_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S22AE_HUMAN
pepstats	swissprot:S22AE_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S22AE_HUMAN
pepwheel	swissprot:S22AE_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S22AE_HUMAN
pepwindow	swissprot:S22AE_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S22AE_HUMAN
sigcleave	swissprot:S22AE_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S22AE_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S26A8_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1 {ECO 0000269|PubMed 11278976, ECO 0000269|PubMed 11834742, ECO 0000269|Ref.3}; IsoId=Q96RN1-1; Sequence=Displayed; Name=2 {ECO 0000269|PubMed 15489334}; IsoId=Q96RN1-2; Sequence=VSP_052705; Note=No experimental confirmation available. {ECO 0000305}; Name=3 {ECO 0000269|PubMed 14574404}; IsoId=Q96RN1-3; Sequence=VSP_052704, VSP_052706; Note=No experimental confirmation available. {ECO 0000305}; Name=4 {ECO 0000269|PubMed 14702039}; IsoId=Q96RN1-4; Sequence=VSP_052707, VSP_052708; Note=No experimental confirmation available. {ECO 0000305}; 
# AltName	S26A8_HUMAN	Anion exchange transporter
# AltName	S26A8_HUMAN	Solute carrier family 26 member 8
# BioGrid	125501	2
# CCDS	CCDS4813	-. [Q96RN1-1]
# CCDS	CCDS4814	-. [Q96RN1-2]
# DISEASE	S26A8_HUMAN	Spermatogenic failure 3 (SPGF3) [MIM 606766]  A disorder characterized by primary infertility, sperm morphologic abnormalities, and moderate to severe asthenozoospermia, condition in which the percentage of progressively motile sperm is abnormally low. {ECO 0000269|PubMed 23582645}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# ENZYME REGULATION	S26A8_HUMAN	Activity is inhibited by 4,4'-Di- isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters), gluconate, and by thiosulfate. 
# Ensembl	ENST00000355574	ENSP00000347778; ENSG00000112053. [Q96RN1-1]
# Ensembl	ENST00000394602	ENSP00000378100; ENSG00000112053. [Q96RN1-2]
# Ensembl	ENST00000490799	ENSP00000417638; ENSG00000112053. [Q96RN1-1]
# ExpressionAtlas	Q96RN1	baseline and differential
# FUNCTION	S26A8_HUMAN	Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. May form a moleculer complex involved in the regulation of chloride and bicarbonate ions fluxes during sperm capacitation. {ECO 0000269|PubMed 11278976, ECO 0000269|PubMed 11834742, ECO 0000269|PubMed 22121115}. 
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0005254	chloride channel activity; IDA:UniProtKB.
# GO_function	GO:0008271	secondary active sulfate transmembrane transporter activity; IEA:InterPro.
# GO_function	GO:0015106	bicarbonate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015116	sulfate transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0019531	oxalate transmembrane transporter activity; IDA:UniProtKB.
# GO_function	S26A8_HUMAN	GO 0015301 anion anion antiporter activity; IBA GO_Central.
# GO_process	GO:0006820	anion transport; IDA:UniProtKB.
# GO_process	GO:0006821	chloride transport; IDA:UniProtKB.
# GO_process	GO:0007275	multicellular organism development; IEA:UniProtKB-KW.
# GO_process	GO:0008272	sulfate transport; IDA:UniProtKB.
# GO_process	GO:0015701	bicarbonate transport; IBA:GO_Central.
# GO_process	GO:0019532	oxalate transport; IDA:UniProtKB.
# GO_process	GO:0030317	flagellated sperm motility; IEA:InterPro.
# GO_process	GO:0042391	regulation of membrane potential; IBA:GO_Central.
# GO_process	GO:0048240	sperm capacitation; IEA:InterPro.
# GO_process	GO:0051321	meiotic cell cycle; IEA:UniProtKB-KW.
# GO_process	GO:0051453	regulation of intracellular pH; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007049	cell cycle
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0021700	developmental maturation
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0048870	cell motility
# Gene3D	3.30.750.24	-; 2.
# Genevisible	Q96RN1	HS
# HGNC	HGNC:14468	SLC26A8
# INDUCTION	Repressed by tunicamycin, an inhibitor of N- glycosylation. {ECO:0000269|PubMed	11278976}. 
# INTERACTION	S26A8_HUMAN	P13569 CFTR; NbExp=2; IntAct=EBI-1792052, EBI-349854; Q9H0H5 RACGAP1; NbExp=2; IntAct=EBI-1792052, EBI-717233; 
# IntAct	Q96RN1	2
# InterPro	IPR001902	SLC26A/SulP_fam
# InterPro	IPR002645	STAS_dom
# InterPro	IPR011547	SLC26A/SulP_dom
# InterPro	IPR030303	SLC26A8
# KEGG_Brite	ko02001	Solute carrier family
# MIM	606766	phenotype
# MIM	608480	gene
# Organism	S26A8_HUMAN	Homo sapiens (Human)
# Orphanet	276234	Non-syndromic male infertility due to sperm motility disorder
# PANTHER	PTHR11814	PTHR11814; 2
# PANTHER	PTHR11814:SF11	PTHR11814:SF11; 2
# PROSITE	PS50801	STAS
# PTM	S26A8_HUMAN	N-glycosylated. {ECO 0000269|PubMed 11278976}. 
# Pfam	PF00916	Sulfate_transp
# Pfam	PF01740	STAS
# Proteomes	UP000005640	Chromosome 6
# RecName	S26A8_HUMAN	Testis anion transporter 1
# RefSeq	NP_001180405	NM_001193476.1. [Q96RN1-1]
# RefSeq	NP_443193	NM_052961.3. [Q96RN1-1]
# RefSeq	NP_619732	NM_138718.2. [Q96RN1-2]
# RefSeq	XP_016865724	XM_017010235.1. [Q96RN1-1]
# SEQUENCE CAUTION	Sequence=AAO26699.1; Type=Miscellaneous discrepancy; Note=Incorrectly indicated as originating from mouse.; Evidence={ECO:0000305}; Sequence=BAB71408.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. {ECO	0000255}. 
# SIMILARITY	Contains 1 STAS domain. {ECO:0000255|PROSITE- ProRule	PRU00198}. 
# SUBCELLULAR LOCATION	S26A8_HUMAN	Membrane {ECO 0000269|PubMed 11278976, ECO 0000269|PubMed 17517695}; Multi-pass membrane protein {ECO 0000269|PubMed 11278976, ECO 0000269|PubMed 17517695}. Note=Located at the annulus ring structure within the sperm cell. {ECO 0000269|PubMed 11278976, ECO 0000269|PubMed 17517695}. 
# SUBUNIT	S26A8_HUMAN	Interacts with RACGAP1. Interacts with CFTR. {ECO 0000269|PubMed 11278976, ECO 0000269|PubMed 22121115}. 
# SUPFAM	SSF52091	SSF52091; 2
# TCDB	2.A.53.2.14	the sulfate permease (sulp) family
# TISSUE SPECIFICITY	S26A8_HUMAN	Expression observed exclusively in testis, restricted to the meiotic phase of the germ cell. Abundant expression located in the seminiferous tubules, concentrated on the luminal side of the tubuli harboring the spermatocytes and spermatids. Expressed in spermatozoa. {ECO 0000269|PubMed 11278976, ECO 0000269|PubMed 11834742}. 
# UCSC	uc003oll	human. [Q96RN1-1]
# eggNOG	COG0659	LUCA
# eggNOG	KOG0236	Eukaryota
BLAST	swissprot:S26A8_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S26A8_HUMAN
BioCyc	ZFISH:ENSG00000112053-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000112053-MONOMER
COXPRESdb	116369	http://coxpresdb.jp/data/gene/116369.shtml
CleanEx	HS_SLC26A8	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC26A8
DOI	10.1016/j.ajhg.2013.03.016	http://dx.doi.org/10.1016/j.ajhg.2013.03.016
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M011740200	http://dx.doi.org/10.1074/jbc.M011740200
DOI	10.1074/jbc.M111802200	http://dx.doi.org/10.1074/jbc.M111802200
DOI	10.1093/hmg/ddm117	http://dx.doi.org/10.1093/hmg/ddm117
DOI	10.1093/hmg/ddr558	http://dx.doi.org/10.1093/hmg/ddr558
DOI	10.1093/molehr/gah140	http://dx.doi.org/10.1093/molehr/gah140
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF314959	http://www.ebi.ac.uk/ena/data/view/AF314959
EMBL	AF331522	http://www.ebi.ac.uk/ena/data/view/AF331522
EMBL	AF403499	http://www.ebi.ac.uk/ena/data/view/AF403499
EMBL	AK057276	http://www.ebi.ac.uk/ena/data/view/AK057276
EMBL	AL133507	http://www.ebi.ac.uk/ena/data/view/AL133507
EMBL	AL133507	http://www.ebi.ac.uk/ena/data/view/AL133507
EMBL	AL133507	http://www.ebi.ac.uk/ena/data/view/AL133507
EMBL	BC025408	http://www.ebi.ac.uk/ena/data/view/BC025408
EMBL	CH471081	http://www.ebi.ac.uk/ena/data/view/CH471081
EMBL	Z95152	http://www.ebi.ac.uk/ena/data/view/Z95152
EMBL	Z95152	http://www.ebi.ac.uk/ena/data/view/Z95152
Ensembl	ENST00000355574	http://www.ensembl.org/id/ENST00000355574
Ensembl	ENST00000394602	http://www.ensembl.org/id/ENST00000394602
Ensembl	ENST00000490799	http://www.ensembl.org/id/ENST00000490799
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0008271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008271
GO_function	GO:0015106	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015106
GO_function	GO:0015116	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015116
GO_function	GO:0015301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015301
GO_function	GO:0019531	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019531
GO_process	GO:0006820	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006820
GO_process	GO:0006821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006821
GO_process	GO:0007275	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007275
GO_process	GO:0008272	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008272
GO_process	GO:0015701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015701
GO_process	GO:0019532	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019532
GO_process	GO:0030317	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030317
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0048240	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048240
GO_process	GO:0051321	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051321
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007049	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0021700	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021700
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
Gene3D	3.30.750.24	http://www.cathdb.info/version/latest/superfamily/3.30.750.24
GeneCards	SLC26A8	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC26A8
GeneID	116369	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=116369
GeneTree	ENSGT00760000119026	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119026
HGNC	HGNC:14468	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14468
HOGENOM	HOG000154234	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000154234&db=HOGENOM6
HOVERGEN	HBG108443	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108443&db=HOVERGEN
HPA	HPA038080	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA038080
HPA	HPA038081	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA038081
InParanoid	Q96RN1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96RN1
IntAct	Q96RN1	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96RN1*
InterPro	IPR001902	http://www.ebi.ac.uk/interpro/entry/IPR001902
InterPro	IPR002645	http://www.ebi.ac.uk/interpro/entry/IPR002645
InterPro	IPR011547	http://www.ebi.ac.uk/interpro/entry/IPR011547
InterPro	IPR030303	http://www.ebi.ac.uk/interpro/entry/IPR030303
Jabion	116369	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=116369
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:116369	http://www.genome.jp/dbget-bin/www_bget?hsa:116369
KEGG_Orthology	KO:K14705	http://www.genome.jp/dbget-bin/www_bget?KO:K14705
MIM	606766	http://www.ncbi.nlm.nih.gov/omim/606766
MIM	608480	http://www.ncbi.nlm.nih.gov/omim/608480
OMA	FGSCHQM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FGSCHQM
Orphanet	276234	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=276234
OrthoDB	EOG091G025O	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G025O
PANTHER	PTHR11814	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11814
PANTHER	PTHR11814:SF11	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11814:SF11
PROSITE	PS50801	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50801
PSORT	swissprot:S26A8_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S26A8_HUMAN
PSORT-B	swissprot:S26A8_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S26A8_HUMAN
PSORT2	swissprot:S26A8_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S26A8_HUMAN
Pfam	PF00916	http://pfam.xfam.org/family/PF00916
Pfam	PF01740	http://pfam.xfam.org/family/PF01740
PharmGKB	PA37885	http://www.pharmgkb.org/do/serve?objId=PA37885&objCls=Gene
Phobius	swissprot:S26A8_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S26A8_HUMAN
PhylomeDB	Q96RN1	http://phylomedb.org/?seqid=Q96RN1
ProteinModelPortal	Q96RN1	http://www.proteinmodelportal.org/query/uniprot/Q96RN1
PubMed	11278976	http://www.ncbi.nlm.nih.gov/pubmed/11278976
PubMed	11834742	http://www.ncbi.nlm.nih.gov/pubmed/11834742
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15579655	http://www.ncbi.nlm.nih.gov/pubmed/15579655
PubMed	17517695	http://www.ncbi.nlm.nih.gov/pubmed/17517695
PubMed	22121115	http://www.ncbi.nlm.nih.gov/pubmed/22121115
PubMed	23582645	http://www.ncbi.nlm.nih.gov/pubmed/23582645
RefSeq	NP_001180405	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001180405
RefSeq	NP_443193	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_443193
RefSeq	NP_619732	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_619732
RefSeq	XP_016865724	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016865724
STRING	9606.ENSP00000347778	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000347778&targetmode=cogs
SUPFAM	SSF52091	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52091
TCDB	2.A.53.2.14	http://www.tcdb.org/search/result.php?tc=2.A.53.2.14
UCSC	uc003oll	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003oll&org=rat
UniGene	Hs.435836	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.435836
UniProtKB	S26A8_HUMAN	http://www.uniprot.org/uniprot/S26A8_HUMAN
UniProtKB-AC	Q96RN1	http://www.uniprot.org/uniprot/Q96RN1
charge	swissprot:S26A8_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S26A8_HUMAN
eggNOG	COG0659	http://eggnogapi.embl.de/nog_data/html/tree/COG0659
eggNOG	KOG0236	http://eggnogapi.embl.de/nog_data/html/tree/KOG0236
epestfind	swissprot:S26A8_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S26A8_HUMAN
garnier	swissprot:S26A8_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S26A8_HUMAN
helixturnhelix	swissprot:S26A8_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S26A8_HUMAN
hmoment	swissprot:S26A8_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S26A8_HUMAN
iep	swissprot:S26A8_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S26A8_HUMAN
inforesidue	swissprot:S26A8_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S26A8_HUMAN
neXtProt	NX_Q96RN1	http://www.nextprot.org/db/entry/NX_Q96RN1
octanol	swissprot:S26A8_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S26A8_HUMAN
pepcoil	swissprot:S26A8_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S26A8_HUMAN
pepdigest	swissprot:S26A8_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S26A8_HUMAN
pepinfo	swissprot:S26A8_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S26A8_HUMAN
pepnet	swissprot:S26A8_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S26A8_HUMAN
pepstats	swissprot:S26A8_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S26A8_HUMAN
pepwheel	swissprot:S26A8_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S26A8_HUMAN
pepwindow	swissprot:S26A8_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S26A8_HUMAN
sigcleave	swissprot:S26A8_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S26A8_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AT2A1_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=SERCA1B; Synonyms=ATP2A1B, Neonatal; IsoId=O14983-1; Sequence=Displayed; Name=SERCA1A; Synonyms=ATP2A1A, Adult; IsoId=O14983-2; Sequence=VSP_000355; Name=3; IsoId=O14983-3; Sequence=VSP_054770, VSP_000355; Note=No experimental confirmation available.; 
# AltName	AT2A1_HUMAN	Calcium pump 1
# AltName	AT2A1_HUMAN	Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform
# AltName	AT2A1_HUMAN	Endoplasmic reticulum class 1/2 Ca(2+) ATPase
# BioGrid	106977	17
# CATALYTIC ACTIVITY	AT2A1_HUMAN	ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2). 
# CCDS	CCDS10643	-. [O14983-1]
# CCDS	CCDS42139	-. [O14983-2]
# CCDS	CCDS66997	-. [O14983-3]
# DEVELOPMENTAL STAGE	Isoform SERCA1A accounts for more than 99% of SERCA1 isoforms expressed in adult skeletal muscle, while isoform SERCA1B predominates in neo-natal skeletal muscle. {ECO:0000269|PubMed	8825625}. 
# DISEASE	AT2A1_HUMAN	Brody myopathy (BRM) [MIM 601003]  A disorder of muscle function that is characterized by painless muscle cramping and exercise-induced impairment of muscle relaxation. {ECO 0000269|PubMed 10914677}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# ENZYME REGULATION	AT2A1_HUMAN	Inhibited by sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN) (By similarity). Reversibly inhibited by phospholamban (PLN) at low calcium concentrations (By similarity). Dephosphorylated PLN decreases the apparent affinity of the ATPase for calcium. This inhibition is regulated by the phosphorylation of PLN (By similarity). Enhanced by DWORF; DWORF increases activity by displacing sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN) (By similarity). {ECO 0000250|UniProtKB P04191, ECO 0000250|UniProtKB Q8R429}. 
# Ensembl	ENST00000357084	ENSP00000349595; ENSG00000196296. [O14983-1]
# Ensembl	ENST00000395503	ENSP00000378879; ENSG00000196296. [O14983-2]
# Ensembl	ENST00000536376	ENSP00000443101; ENSG00000196296. [O14983-3]
# ExpressionAtlas	O14983	baseline and differential
# FUNCTION	AT2A1_HUMAN	Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. {ECO 0000250|UniProtKB Q8R429}. 
# GO_component	GO:0005739	mitochondrion; IEA:GOC.
# GO_component	GO:0005789	endoplasmic reticulum membrane; IDA:UniProtKB.
# GO_component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment; ISS:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016020	membrane; ISS:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0016529	sarcoplasmic reticulum; ISS:UniProtKB.
# GO_component	GO:0031095	platelet dense tubular network membrane; TAS:Reactome.
# GO_component	GO:0031673	H zone; IDA:UniProtKB.
# GO_component	GO:0031674	I band; IDA:UniProtKB.
# GO_component	GO:0033017	sarcoplasmic reticulum membrane; ISS:UniProtKB.
# GO_component	GO:0034704	calcium channel complex; IC:BHF-UCL.
# GO_component	GO:0048471	perinuclear region of cytoplasm; ISS:UniProtKB.
# GO_function	GO:0005388	calcium-transporting ATPase activity; IDA:UniProtKB.
# GO_function	GO:0005509	calcium ion binding; IMP:UniProtKB.
# GO_function	GO:0005524	ATP binding; ISS:UniProtKB.
# GO_function	GO:0042803	protein homodimerization activity; IPI:BHF-UCL.
# GO_process	GO:0006816	calcium ion transport; IDA:UniProtKB.
# GO_process	GO:0006942	regulation of striated muscle contraction; IMP:UniProtKB.
# GO_process	GO:0008637	apoptotic mitochondrial changes; IMP:BHF-UCL.
# GO_process	GO:0031448	positive regulation of fast-twitch skeletal muscle fiber contraction; IDA:UniProtKB.
# GO_process	GO:0032470	positive regulation of endoplasmic reticulum calcium ion concentration; IMP:BHF-UCL.
# GO_process	GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration; IMP:BHF-UCL.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0034976	response to endoplasmic reticulum stress; IMP:BHF-UCL.
# GO_process	GO:0045988	negative regulation of striated muscle contraction; IMP:UniProtKB.
# GO_process	GO:0051561	positive regulation of mitochondrial calcium ion concentration; IMP:BHF-UCL.
# GO_process	GO:0051659	maintenance of mitochondrion location; IMP:BHF-UCL.
# GO_process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IMP:BHF-UCL.
# GO_process	GO:0070509	calcium ion import; IMP:BHF-UCL.
# GO_process	GO:0090076	relaxation of skeletal muscle; IDA:BHF-UCL.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007005	mitochondrion organization
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.1110.10	-; 2.
# Gene3D	2.70.150.10	-; 2.
# Gene3D	3.40.1110.10	-; 1.
# Genevisible	O14983	HS
# HGNC	HGNC:811	ATP2A1
# INDUCTION	Increased contractile activity leads to a decrease in SERCA1 expression, while decreased contractile activity leads to an increase in SERCA1 expression. {ECO:0000269|PubMed	8825625}. 
# IntAct	O14983	5
# InterPro	IPR001757	P_typ_ATPase
# InterPro	IPR004014	ATPase_P-typ_cation-transptr_N
# InterPro	IPR005782	P-type_ATPase_IIA
# InterPro	IPR006068	ATPase_P-typ_cation-transptr_C
# InterPro	IPR008250	ATPase_P-typ_transduc_dom_A
# InterPro	IPR018303	ATPase_P-typ_P_site
# InterPro	IPR023214	HAD-like_dom
# InterPro	IPR023298	ATPase_P-typ_TM_dom
# InterPro	IPR023299	ATPase_P-typ_cyto_domN
# InterPro	IPR030332	SERCA1
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Disease	H01129	[Musculoskeletal disease; Nervous system disease] Brody myopathy
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04972	Pancreatic secretion
# KEGG_Pathway	ko05010	Alzheimer's disease
# MIM	108730	gene
# MIM	601003	phenotype
# Organism	AT2A1_HUMAN	Homo sapiens (Human)
# Orphanet	53347	Brody myopathy
# PANTHER	PTHR24093:SF335	PTHR24093:SF335; 2
# PRINTS	PR00120	HATPASE
# PROSITE	PS00154	ATPASE_E1_E2
# Pfam	PF00122	E1-E2_ATPase
# Pfam	PF00689	Cation_ATPase_C
# Pfam	PF00690	Cation_ATPase_N
# Pfam	PF08282	Hydrolase_3
# Proteomes	UP000005640	Chromosome 16
# Reactome	R-HSA-1912420	Pre-NOTCH Processing in Golgi
# Reactome	R-HSA-418359	Reduction of cytosolic Ca++ levels
# Reactome	R-HSA-5578775	Ion homeostasis
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	AT2A1_HUMAN	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
# RefSeq	NP_001273004	NM_001286075.1. [O14983-3]
# RefSeq	NP_004311	NM_004320.4. [O14983-2]
# RefSeq	NP_775293	NM_173201.3. [O14983-1]
# SIMILARITY	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. {ECO	0000305}.
# SMART	SM00831	Cation_ATPase_N
# SUBCELLULAR LOCATION	AT2A1_HUMAN	Endoplasmic reticulum membrane {ECO 0000250|UniProtKB P04191}; Multi-pass membrane protein {ECO 0000255}. Sarcoplasmic reticulum membrane {ECO 0000250|UniProtKB P04191}; Multi-pass membrane protein {ECO 0000255}. 
# SUBUNIT	Interacts with sarcolipin (SLN) (By similarity). Interacts with phospholamban (PLN) (By similarity). Interacts with myoregulin (MRLN). Interacts with DWORF (By similarity). {ECO:0000250|UniProtKB	Q8R429}. 
# SUPFAM	SSF56784	SSF56784
# SUPFAM	SSF81660	SSF81660
# TIGRFAMs	TIGR01116	ATPase-IIA1_Ca
# TIGRFAMs	TIGR01494	ATPase_P-type; 2
# TISSUE SPECIFICITY	Skeletal muscle, fast twitch muscle (type II) fibers. {ECO:0000269|PubMed	8825625}. 
# UCSC	uc002drn	human. [O14983-1]
# eggNOG	COG0474	LUCA
# eggNOG	KOG0202	Eukaryota
BLAST	swissprot:AT2A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AT2A1_HUMAN
BioCyc	ZFISH:HS11229-MONOMER	http://biocyc.org/getid?id=ZFISH:HS11229-MONOMER
COXPRESdb	487	http://coxpresdb.jp/data/gene/487.shtml
CleanEx	HS_ATP2A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP2A1
DOI	10.1006/geno.1995.1259	http://dx.doi.org/10.1006/geno.1995.1259
DOI	10.1007/s004390000297	http://dx.doi.org/10.1007/s004390000297
DOI	10.1038/nature03187	http://dx.doi.org/10.1038/nature03187
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M101229200	http://dx.doi.org/10.1074/jbc.M101229200
EC_number	EC:3.6.3.8	http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.8
EMBL	AC109460	http://www.ebi.ac.uk/ena/data/view/AC109460
EMBL	AC133550	http://www.ebi.ac.uk/ena/data/view/AC133550
EMBL	AK128456	http://www.ebi.ac.uk/ena/data/view/AK128456
EMBL	AK291314	http://www.ebi.ac.uk/ena/data/view/AK291314
EMBL	U96773	http://www.ebi.ac.uk/ena/data/view/U96773
EMBL	U96773	http://www.ebi.ac.uk/ena/data/view/U96773
EMBL	U96774	http://www.ebi.ac.uk/ena/data/view/U96774
EMBL	U96774	http://www.ebi.ac.uk/ena/data/view/U96774
EMBL	U96775	http://www.ebi.ac.uk/ena/data/view/U96775
EMBL	U96775	http://www.ebi.ac.uk/ena/data/view/U96775
EMBL	U96776	http://www.ebi.ac.uk/ena/data/view/U96776
EMBL	U96776	http://www.ebi.ac.uk/ena/data/view/U96776
EMBL	U96777	http://www.ebi.ac.uk/ena/data/view/U96777
EMBL	U96777	http://www.ebi.ac.uk/ena/data/view/U96777
EMBL	U96778	http://www.ebi.ac.uk/ena/data/view/U96778
EMBL	U96778	http://www.ebi.ac.uk/ena/data/view/U96778
EMBL	U96779	http://www.ebi.ac.uk/ena/data/view/U96779
EMBL	U96779	http://www.ebi.ac.uk/ena/data/view/U96779
EMBL	U96780	http://www.ebi.ac.uk/ena/data/view/U96780
EMBL	U96780	http://www.ebi.ac.uk/ena/data/view/U96780
EMBL	U96781	http://www.ebi.ac.uk/ena/data/view/U96781
EMBL	U96781	http://www.ebi.ac.uk/ena/data/view/U96781
ENZYME	3.6.3.8	http://enzyme.expasy.org/EC/3.6.3.8
Ensembl	ENST00000357084	http://www.ensembl.org/id/ENST00000357084
Ensembl	ENST00000395503	http://www.ensembl.org/id/ENST00000395503
Ensembl	ENST00000536376	http://www.ensembl.org/id/ENST00000536376
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005793	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005793
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016529	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016529
GO_component	GO:0031095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031095
GO_component	GO:0031673	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031673
GO_component	GO:0031674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031674
GO_component	GO:0033017	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033017
GO_component	GO:0034704	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034704
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_function	GO:0005388	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005388
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0006942	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006942
GO_process	GO:0008637	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008637
GO_process	GO:0031448	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031448
GO_process	GO:0032470	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032470
GO_process	GO:0032471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032471
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0034976	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034976
GO_process	GO:0045988	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045988
GO_process	GO:0051561	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051561
GO_process	GO:0051659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051659
GO_process	GO:0070059	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070059
GO_process	GO:0070509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070509
GO_process	GO:0090076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090076
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007005
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.1110.10	http://www.cathdb.info/version/latest/superfamily/1.20.1110.10
Gene3D	2.70.150.10	http://www.cathdb.info/version/latest/superfamily/2.70.150.10
Gene3D	3.40.1110.10	http://www.cathdb.info/version/latest/superfamily/3.40.1110.10
GeneCards	ATP2A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP2A1
GeneID	487	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=487
GeneTree	ENSGT00850000132256	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00850000132256
HGNC	HGNC:811	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:811
HOGENOM	HOG000265621	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265621&db=HOGENOM6
HOVERGEN	HBG105648	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG105648&db=HOVERGEN
HPA	CAB002310	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB002310
HPA	CAB032706	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB032706
InParanoid	O14983	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O14983
IntAct	O14983	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O14983*
IntEnz	3.6.3.8	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.8
InterPro	IPR001757	http://www.ebi.ac.uk/interpro/entry/IPR001757
InterPro	IPR004014	http://www.ebi.ac.uk/interpro/entry/IPR004014
InterPro	IPR005782	http://www.ebi.ac.uk/interpro/entry/IPR005782
InterPro	IPR006068	http://www.ebi.ac.uk/interpro/entry/IPR006068
InterPro	IPR008250	http://www.ebi.ac.uk/interpro/entry/IPR008250
InterPro	IPR018303	http://www.ebi.ac.uk/interpro/entry/IPR018303
InterPro	IPR023214	http://www.ebi.ac.uk/interpro/entry/IPR023214
InterPro	IPR023298	http://www.ebi.ac.uk/interpro/entry/IPR023298
InterPro	IPR023299	http://www.ebi.ac.uk/interpro/entry/IPR023299
InterPro	IPR030332	http://www.ebi.ac.uk/interpro/entry/IPR030332
Jabion	487	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=487
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Disease	H01129	http://www.genome.jp/dbget-bin/www_bget?H01129
KEGG_Gene	hsa:487	http://www.genome.jp/dbget-bin/www_bget?hsa:487
KEGG_Orthology	KO:K05853	http://www.genome.jp/dbget-bin/www_bget?KO:K05853
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
MIM	108730	http://www.ncbi.nlm.nih.gov/omim/108730
MIM	601003	http://www.ncbi.nlm.nih.gov/omim/601003
MINT	MINT-1158140	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1158140
OMA	LAHWLMV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LAHWLMV
Orphanet	53347	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=53347
OrthoDB	EOG091G01LE	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01LE
PANTHER	PTHR24093:SF335	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24093:SF335
PRINTS	PR00120	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00120
PROSITE	PS00154	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00154
PSORT	swissprot:AT2A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AT2A1_HUMAN
PSORT-B	swissprot:AT2A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AT2A1_HUMAN
PSORT2	swissprot:AT2A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AT2A1_HUMAN
Pfam	PF00122	http://pfam.xfam.org/family/PF00122
Pfam	PF00689	http://pfam.xfam.org/family/PF00689
Pfam	PF00690	http://pfam.xfam.org/family/PF00690
Pfam	PF08282	http://pfam.xfam.org/family/PF08282
PharmGKB	PA25105	http://www.pharmgkb.org/do/serve?objId=PA25105&objCls=Gene
Phobius	swissprot:AT2A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AT2A1_HUMAN
PhylomeDB	O14983	http://phylomedb.org/?seqid=O14983
ProteinModelPortal	O14983	http://www.proteinmodelportal.org/query/uniprot/O14983
PubMed	10914677	http://www.ncbi.nlm.nih.gov/pubmed/10914677
PubMed	11438520	http://www.ncbi.nlm.nih.gov/pubmed/11438520
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15616553	http://www.ncbi.nlm.nih.gov/pubmed/15616553
PubMed	8825625	http://www.ncbi.nlm.nih.gov/pubmed/8825625
Reactome	R-HSA-1912420	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1912420
Reactome	R-HSA-418359	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418359
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_001273004	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273004
RefSeq	NP_004311	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004311
RefSeq	NP_775293	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_775293
SMART	SM00831	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00831
SMR	O14983	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O14983
STRING	9606.ENSP00000349595	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000349595&targetmode=cogs
SUPFAM	SSF56784	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784
SUPFAM	SSF81660	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81660
TIGRFAMs	TIGR01116	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01116
TIGRFAMs	TIGR01494	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01494
UCSC	uc002drn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002drn&org=rat
UniGene	Hs.657344	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.657344
UniProtKB	AT2A1_HUMAN	http://www.uniprot.org/uniprot/AT2A1_HUMAN
UniProtKB-AC	O14983	http://www.uniprot.org/uniprot/O14983
charge	swissprot:AT2A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AT2A1_HUMAN
eggNOG	COG0474	http://eggnogapi.embl.de/nog_data/html/tree/COG0474
eggNOG	KOG0202	http://eggnogapi.embl.de/nog_data/html/tree/KOG0202
epestfind	swissprot:AT2A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AT2A1_HUMAN
garnier	swissprot:AT2A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AT2A1_HUMAN
helixturnhelix	swissprot:AT2A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AT2A1_HUMAN
hmoment	swissprot:AT2A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AT2A1_HUMAN
iep	swissprot:AT2A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AT2A1_HUMAN
inforesidue	swissprot:AT2A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AT2A1_HUMAN
neXtProt	NX_O14983	http://www.nextprot.org/db/entry/NX_O14983
octanol	swissprot:AT2A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AT2A1_HUMAN
pepcoil	swissprot:AT2A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AT2A1_HUMAN
pepdigest	swissprot:AT2A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AT2A1_HUMAN
pepinfo	swissprot:AT2A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AT2A1_HUMAN
pepnet	swissprot:AT2A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AT2A1_HUMAN
pepstats	swissprot:AT2A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AT2A1_HUMAN
pepwheel	swissprot:AT2A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AT2A1_HUMAN
pepwindow	swissprot:AT2A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AT2A1_HUMAN
sigcleave	swissprot:AT2A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AT2A1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	FA26D_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q5JW98-1; Sequence=Displayed; Name=2; IsoId=Q5JW98-2; Sequence=VSP_013817; Name=3; IsoId=Q5JW98-3; Sequence=VSP_018252; Name=4; IsoId=Q5JW98-4; Sequence=VSP_045216; 
# BioGrid	128707	15
# CCDS	CCDS5109	-. [Q5JW98-2]
# CCDS	CCDS59031	-. [Q5JW98-4]
# CCDS	CCDS59032	-. [Q5JW98-3]
# Ensembl	ENST00000368596	ENSP00000357585; ENSG00000164451. [Q5JW98-1]
# Ensembl	ENST00000368597	ENSP00000357586; ENSG00000164451. [Q5JW98-2]
# Ensembl	ENST00000405399	ENSP00000385836; ENSG00000164451. [Q5JW98-3]
# Ensembl	ENST00000628083	ENSP00000487169; ENSG00000164451. [Q5JW98-4]
# ExpressionAtlas	Q5JW98	baseline and differential
# FUNCTION	FA26D_HUMAN	Pore-forming subunit of a voltage-gated ion channel. {ECO 0000250}. 
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0005261	cation channel activity; IBA:GO_Central.
# GO_process	GO:0034220	ion transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# HGNC	HGNC:21094	FAM26D
# InterPro	IPR029569	FAM26
# InterPro	IPR029574	FAM26D
# Organism	FA26D_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR32261	PTHR32261
# PANTHER	PTHR32261:SF5	PTHR32261:SF5
# Pfam	PF14798	Ca_hom_mod
# Proteomes	UP000005640	Chromosome 6
# RecName	FA26D_HUMAN	Protein FAM26D
# RefSeq	NP_001243816	NM_001256887.2. [Q5JW98-3]
# RefSeq	NP_001243817	NM_001256888.2. [Q5JW98-4]
# RefSeq	NP_001243818	NM_001256889.2. [Q5JW98-2]
# RefSeq	NP_694581	NM_153036.4. [Q5JW98-2]
# RefSeq	XP_005266917	XM_005266860.3. [Q5JW98-1]
# SIMILARITY	Belongs to the FAM26 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	FA26D_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	1.A.84.1	the calcium homeostasis modulator ca(2+) channel (calhm-c) family
# UCSC	uc003pwz	human. [Q5JW98-1]
# eggNOG	ENOG410KCWY	Eukaryota
# eggNOG	ENOG4110NTE	LUCA
BLAST	swissprot:FA26D_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:FA26D_HUMAN
COXPRESdb	221301	http://coxpresdb.jp/data/gene/221301.shtml
CleanEx	HS_FAM26D	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_FAM26D
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AK056801	http://www.ebi.ac.uk/ena/data/view/AK056801
EMBL	AK300309	http://www.ebi.ac.uk/ena/data/view/AK300309
EMBL	AL121953	http://www.ebi.ac.uk/ena/data/view/AL121953
EMBL	AL121953	http://www.ebi.ac.uk/ena/data/view/AL121953
EMBL	AL121953	http://www.ebi.ac.uk/ena/data/view/AL121953
EMBL	AY358252	http://www.ebi.ac.uk/ena/data/view/AY358252
EMBL	BC057769	http://www.ebi.ac.uk/ena/data/view/BC057769
EMBL	CH471051	http://www.ebi.ac.uk/ena/data/view/CH471051
EMBL	CH471051	http://www.ebi.ac.uk/ena/data/view/CH471051
Ensembl	ENST00000368596	http://www.ensembl.org/id/ENST00000368596
Ensembl	ENST00000368597	http://www.ensembl.org/id/ENST00000368597
Ensembl	ENST00000405399	http://www.ensembl.org/id/ENST00000405399
Ensembl	ENST00000628083	http://www.ensembl.org/id/ENST00000628083
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005261	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005261
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	FAM26D	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=FAM26D
GeneID	221301	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=221301
GeneTree	ENSGT00530000062796	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062796
H-InvDB	HIX0200851	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0200851
HGNC	HGNC:21094	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:21094
HOGENOM	HOG000294134	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294134&db=HOGENOM6
HOVERGEN	HBG099442	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG099442&db=HOVERGEN
HPA	HPA019178	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA019178
HPA	HPA048014	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA048014
InParanoid	Q5JW98	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q5JW98
InterPro	IPR029569	http://www.ebi.ac.uk/interpro/entry/IPR029569
InterPro	IPR029574	http://www.ebi.ac.uk/interpro/entry/IPR029574
Jabion	221301	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=221301
KEGG_Gene	hsa:221301	http://www.genome.jp/dbget-bin/www_bget?hsa:221301
OMA	CPCQVGK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CPCQVGK
OrthoDB	EOG091G0BN1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0BN1
PANTHER	PTHR32261	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32261
PANTHER	PTHR32261:SF5	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32261:SF5
PSORT	swissprot:FA26D_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:FA26D_HUMAN
PSORT-B	swissprot:FA26D_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:FA26D_HUMAN
PSORT2	swissprot:FA26D_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:FA26D_HUMAN
Pfam	PF14798	http://pfam.xfam.org/family/PF14798
PharmGKB	PA162387625	http://www.pharmgkb.org/do/serve?objId=PA162387625&objCls=Gene
Phobius	swissprot:FA26D_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:FA26D_HUMAN
PhylomeDB	Q5JW98	http://phylomedb.org/?seqid=Q5JW98
ProteinModelPortal	Q5JW98	http://www.proteinmodelportal.org/query/uniprot/Q5JW98
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
RefSeq	NP_001243816	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243816
RefSeq	NP_001243817	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243817
RefSeq	NP_001243818	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243818
RefSeq	NP_694581	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_694581
RefSeq	XP_005266917	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005266917
STRING	9606.ENSP00000357586	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000357586&targetmode=cogs
TCDB	1.A.84.1	http://www.tcdb.org/search/result.php?tc=1.A.84.1
UCSC	uc003pwz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003pwz&org=rat
UniGene	Hs.350750	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.350750
UniProtKB	FA26D_HUMAN	http://www.uniprot.org/uniprot/FA26D_HUMAN
UniProtKB-AC	Q5JW98	http://www.uniprot.org/uniprot/Q5JW98
charge	swissprot:FA26D_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:FA26D_HUMAN
eggNOG	ENOG410KCWY	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410KCWY
eggNOG	ENOG4110NTE	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110NTE
epestfind	swissprot:FA26D_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:FA26D_HUMAN
garnier	swissprot:FA26D_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:FA26D_HUMAN
helixturnhelix	swissprot:FA26D_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:FA26D_HUMAN
hmoment	swissprot:FA26D_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:FA26D_HUMAN
iep	swissprot:FA26D_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:FA26D_HUMAN
inforesidue	swissprot:FA26D_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:FA26D_HUMAN
neXtProt	NX_Q5JW98	http://www.nextprot.org/db/entry/NX_Q5JW98
octanol	swissprot:FA26D_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:FA26D_HUMAN
pepcoil	swissprot:FA26D_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:FA26D_HUMAN
pepdigest	swissprot:FA26D_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:FA26D_HUMAN
pepinfo	swissprot:FA26D_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:FA26D_HUMAN
pepnet	swissprot:FA26D_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:FA26D_HUMAN
pepstats	swissprot:FA26D_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:FA26D_HUMAN
pepwheel	swissprot:FA26D_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:FA26D_HUMAN
pepwindow	swissprot:FA26D_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:FA26D_HUMAN
sigcleave	swissprot:FA26D_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:FA26D_HUMAN
## Database	ID	URL or Descriptions
# AltName	ATP8_HUMAN	A6L
# AltName	ATP8_HUMAN	F-ATPase subunit 8
# BioGrid	110613	17
# DISEASE	ATP8_HUMAN	Mitochondrial complex V deficiency, mitochondrial 2 (MC5DM2) [MIM 516070]  A mitochondrial disorder with heterogeneous clinical manifestations including neuropathy, ataxia, hypertrophic cardiomyopathy. Hypertrophic cardiomyopathy can present with negligible to extreme hypertrophy, minimal to extensive fibrosis and myocyte disarray, absent to severe left ventricular outflow tract obstruction, and distinct septal contours/morphologies with extremely varying clinical course. {ECO 0000269|PubMed 19188198}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000361851	ENSP00000355265; ENSG00000228253
# ExpressionAtlas	P03928	baseline and differential
# FUNCTION	ATP8_HUMAN	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity). {ECO 0000250}. 
# GO_component	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); IEA:InterPro.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0005753	mitochondrial proton-transporting ATP synthase complex; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015078	hydrogen ion transmembrane transporter activity; IEA:InterPro.
# GO_function	GO:0022857	transmembrane transporter activity; IC:UniProtKB.
# GO_process	GO:0006754	ATP biosynthetic process; TAS:Reactome.
# GO_process	GO:0042776	mitochondrial ATP synthesis coupled proton transport; IC:UniProtKB.
# GO_process	GO:0055093	response to hyperoxia; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P03928	HS
# HGNC	HGNC:7415	MT-ATP8
# IntAct	P03928	7
# InterPro	IPR001421	ATP8_metazoa
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Disease	H01355	[Inherited metabolic disease; Mitochondrial disease] Kearns-Sayre Syndrome
# KEGG_Disease	H01369	[Inherited metabolic disease; Mitochondrial disease] Mitochondrial infantile bilateral striatal necrosis (MIBSN)
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	516070	gene+phenotype
# Organism	ATP8_HUMAN	Homo sapiens (Human)
# Orphanet	155	Familial isolated hypertrophic cardiomyopathy
# Orphanet	397750	Periodic paralysis with later-onset distal motor neuropathy
# Orphanet	480	Kearns-Sayre syndrome
# PIR	A01062	PWHU8
# Pfam	PF00895	ATP-synt_8
# Proteomes	UP000005640	Mitochondrion
# Reactome	R-HSA-163210	Formation of ATP by chemiosmotic coupling
# RecName	ATP8_HUMAN	ATP synthase protein 8
# RefSeq	YP_003024030	NC_012920.1
# SIMILARITY	Belongs to the ATPase protein 8 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	ATP8_HUMAN	Mitochondrion membrane; Single-pass membrane protein. 
# SUBUNIT	F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity). {ECO	0000250}. 
# eggNOG	ENOG410J587	Eukaryota
# eggNOG	ENOG411154N	LUCA
BLAST	swissprot:ATP8_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ATP8_HUMAN
COXPRESdb	4509	http://coxpresdb.jp/data/gene/4509.shtml
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1007/BF00206061	http://dx.doi.org/10.1007/BF00206061
DOI	10.1007/s00414-004-0427-6	http://dx.doi.org/10.1007/s00414-004-0427-6
DOI	10.1038/290457a0	http://dx.doi.org/10.1038/290457a0
DOI	10.1038/35047064	http://dx.doi.org/10.1038/35047064
DOI	10.1073/pnas.92.2.532	http://dx.doi.org/10.1073/pnas.92.2.532
DOI	10.1093/molbev/msg230	http://dx.doi.org/10.1093/molbev/msg230
DOI	10.1093/nar/26.4.967	http://dx.doi.org/10.1093/nar/26.4.967
DOI	10.1101/gr.686603	http://dx.doi.org/10.1101/gr.686603
DOI	10.1136/jmg.2008.063149	http://dx.doi.org/10.1136/jmg.2008.063149
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF346963	http://www.ebi.ac.uk/ena/data/view/AF346963
EMBL	AF346964	http://www.ebi.ac.uk/ena/data/view/AF346964
EMBL	AF346965	http://www.ebi.ac.uk/ena/data/view/AF346965
EMBL	AF346966	http://www.ebi.ac.uk/ena/data/view/AF346966
EMBL	AF346967	http://www.ebi.ac.uk/ena/data/view/AF346967
EMBL	AF346968	http://www.ebi.ac.uk/ena/data/view/AF346968
EMBL	AF346969	http://www.ebi.ac.uk/ena/data/view/AF346969
EMBL	AF346970	http://www.ebi.ac.uk/ena/data/view/AF346970
EMBL	AF346971	http://www.ebi.ac.uk/ena/data/view/AF346971
EMBL	AF346972	http://www.ebi.ac.uk/ena/data/view/AF346972
EMBL	AF346973	http://www.ebi.ac.uk/ena/data/view/AF346973
EMBL	AF346974	http://www.ebi.ac.uk/ena/data/view/AF346974
EMBL	AF346975	http://www.ebi.ac.uk/ena/data/view/AF346975
EMBL	AF346976	http://www.ebi.ac.uk/ena/data/view/AF346976
EMBL	AF346977	http://www.ebi.ac.uk/ena/data/view/AF346977
EMBL	AF346978	http://www.ebi.ac.uk/ena/data/view/AF346978
EMBL	AF346979	http://www.ebi.ac.uk/ena/data/view/AF346979
EMBL	AF346980	http://www.ebi.ac.uk/ena/data/view/AF346980
EMBL	AF346981	http://www.ebi.ac.uk/ena/data/view/AF346981
EMBL	AF346982	http://www.ebi.ac.uk/ena/data/view/AF346982
EMBL	AF346983	http://www.ebi.ac.uk/ena/data/view/AF346983
EMBL	AF346985	http://www.ebi.ac.uk/ena/data/view/AF346985
EMBL	AF346986	http://www.ebi.ac.uk/ena/data/view/AF346986
EMBL	AF346987	http://www.ebi.ac.uk/ena/data/view/AF346987
EMBL	AF346988	http://www.ebi.ac.uk/ena/data/view/AF346988
EMBL	AF346991	http://www.ebi.ac.uk/ena/data/view/AF346991
EMBL	AF346992	http://www.ebi.ac.uk/ena/data/view/AF346992
EMBL	AF346993	http://www.ebi.ac.uk/ena/data/view/AF346993
EMBL	AF346994	http://www.ebi.ac.uk/ena/data/view/AF346994
EMBL	AF346995	http://www.ebi.ac.uk/ena/data/view/AF346995
EMBL	AF346996	http://www.ebi.ac.uk/ena/data/view/AF346996
EMBL	AF346997	http://www.ebi.ac.uk/ena/data/view/AF346997
EMBL	AF347000	http://www.ebi.ac.uk/ena/data/view/AF347000
EMBL	AF347001	http://www.ebi.ac.uk/ena/data/view/AF347001
EMBL	AF347002	http://www.ebi.ac.uk/ena/data/view/AF347002
EMBL	AF347003	http://www.ebi.ac.uk/ena/data/view/AF347003
EMBL	AF347004	http://www.ebi.ac.uk/ena/data/view/AF347004
EMBL	AF347005	http://www.ebi.ac.uk/ena/data/view/AF347005
EMBL	AF347006	http://www.ebi.ac.uk/ena/data/view/AF347006
EMBL	AF347007	http://www.ebi.ac.uk/ena/data/view/AF347007
EMBL	AF347008	http://www.ebi.ac.uk/ena/data/view/AF347008
EMBL	AF347009	http://www.ebi.ac.uk/ena/data/view/AF347009
EMBL	AF347011	http://www.ebi.ac.uk/ena/data/view/AF347011
EMBL	AF347012	http://www.ebi.ac.uk/ena/data/view/AF347012
EMBL	AF347013	http://www.ebi.ac.uk/ena/data/view/AF347013
EMBL	AF347014	http://www.ebi.ac.uk/ena/data/view/AF347014
EMBL	AF347015	http://www.ebi.ac.uk/ena/data/view/AF347015
EMBL	AY289051	http://www.ebi.ac.uk/ena/data/view/AY289051
EMBL	AY289052	http://www.ebi.ac.uk/ena/data/view/AY289052
EMBL	AY289053	http://www.ebi.ac.uk/ena/data/view/AY289053
EMBL	AY289056	http://www.ebi.ac.uk/ena/data/view/AY289056
EMBL	AY289057	http://www.ebi.ac.uk/ena/data/view/AY289057
EMBL	AY289058	http://www.ebi.ac.uk/ena/data/view/AY289058
EMBL	AY289059	http://www.ebi.ac.uk/ena/data/view/AY289059
EMBL	AY289060	http://www.ebi.ac.uk/ena/data/view/AY289060
EMBL	AY289061	http://www.ebi.ac.uk/ena/data/view/AY289061
EMBL	AY289062	http://www.ebi.ac.uk/ena/data/view/AY289062
EMBL	AY289063	http://www.ebi.ac.uk/ena/data/view/AY289063
EMBL	AY289064	http://www.ebi.ac.uk/ena/data/view/AY289064
EMBL	AY289065	http://www.ebi.ac.uk/ena/data/view/AY289065
EMBL	AY289066	http://www.ebi.ac.uk/ena/data/view/AY289066
EMBL	AY289067	http://www.ebi.ac.uk/ena/data/view/AY289067
EMBL	AY289068	http://www.ebi.ac.uk/ena/data/view/AY289068
EMBL	AY289069	http://www.ebi.ac.uk/ena/data/view/AY289069
EMBL	AY289070	http://www.ebi.ac.uk/ena/data/view/AY289070
EMBL	AY289071	http://www.ebi.ac.uk/ena/data/view/AY289071
EMBL	AY289072	http://www.ebi.ac.uk/ena/data/view/AY289072
EMBL	AY289073	http://www.ebi.ac.uk/ena/data/view/AY289073
EMBL	AY289074	http://www.ebi.ac.uk/ena/data/view/AY289074
EMBL	AY289075	http://www.ebi.ac.uk/ena/data/view/AY289075
EMBL	AY289076	http://www.ebi.ac.uk/ena/data/view/AY289076
EMBL	AY289077	http://www.ebi.ac.uk/ena/data/view/AY289077
EMBL	AY289078	http://www.ebi.ac.uk/ena/data/view/AY289078
EMBL	AY289080	http://www.ebi.ac.uk/ena/data/view/AY289080
EMBL	AY289081	http://www.ebi.ac.uk/ena/data/view/AY289081
EMBL	AY289082	http://www.ebi.ac.uk/ena/data/view/AY289082
EMBL	AY289083	http://www.ebi.ac.uk/ena/data/view/AY289083
EMBL	AY289084	http://www.ebi.ac.uk/ena/data/view/AY289084
EMBL	AY289085	http://www.ebi.ac.uk/ena/data/view/AY289085
EMBL	AY289086	http://www.ebi.ac.uk/ena/data/view/AY289086
EMBL	AY289087	http://www.ebi.ac.uk/ena/data/view/AY289087
EMBL	AY289088	http://www.ebi.ac.uk/ena/data/view/AY289088
EMBL	AY289089	http://www.ebi.ac.uk/ena/data/view/AY289089
EMBL	AY289090	http://www.ebi.ac.uk/ena/data/view/AY289090
EMBL	AY289091	http://www.ebi.ac.uk/ena/data/view/AY289091
EMBL	AY289092	http://www.ebi.ac.uk/ena/data/view/AY289092
EMBL	AY289093	http://www.ebi.ac.uk/ena/data/view/AY289093
EMBL	AY289094	http://www.ebi.ac.uk/ena/data/view/AY289094
EMBL	AY289095	http://www.ebi.ac.uk/ena/data/view/AY289095
EMBL	AY289096	http://www.ebi.ac.uk/ena/data/view/AY289096
EMBL	AY289097	http://www.ebi.ac.uk/ena/data/view/AY289097
EMBL	AY289098	http://www.ebi.ac.uk/ena/data/view/AY289098
EMBL	AY289099	http://www.ebi.ac.uk/ena/data/view/AY289099
EMBL	AY289100	http://www.ebi.ac.uk/ena/data/view/AY289100
EMBL	AY289101	http://www.ebi.ac.uk/ena/data/view/AY289101
EMBL	AY289102	http://www.ebi.ac.uk/ena/data/view/AY289102
EMBL	AY339402	http://www.ebi.ac.uk/ena/data/view/AY339402
EMBL	AY339403	http://www.ebi.ac.uk/ena/data/view/AY339403
EMBL	AY339404	http://www.ebi.ac.uk/ena/data/view/AY339404
EMBL	AY339405	http://www.ebi.ac.uk/ena/data/view/AY339405
EMBL	AY339406	http://www.ebi.ac.uk/ena/data/view/AY339406
EMBL	AY339407	http://www.ebi.ac.uk/ena/data/view/AY339407
EMBL	AY339408	http://www.ebi.ac.uk/ena/data/view/AY339408
EMBL	AY339409	http://www.ebi.ac.uk/ena/data/view/AY339409
EMBL	AY339410	http://www.ebi.ac.uk/ena/data/view/AY339410
EMBL	AY339411	http://www.ebi.ac.uk/ena/data/view/AY339411
EMBL	AY339412	http://www.ebi.ac.uk/ena/data/view/AY339412
EMBL	AY339413	http://www.ebi.ac.uk/ena/data/view/AY339413
EMBL	AY339414	http://www.ebi.ac.uk/ena/data/view/AY339414
EMBL	AY339415	http://www.ebi.ac.uk/ena/data/view/AY339415
EMBL	AY339416	http://www.ebi.ac.uk/ena/data/view/AY339416
EMBL	AY339417	http://www.ebi.ac.uk/ena/data/view/AY339417
EMBL	AY339418	http://www.ebi.ac.uk/ena/data/view/AY339418
EMBL	AY339419	http://www.ebi.ac.uk/ena/data/view/AY339419
EMBL	AY339420	http://www.ebi.ac.uk/ena/data/view/AY339420
EMBL	AY339421	http://www.ebi.ac.uk/ena/data/view/AY339421
EMBL	AY339422	http://www.ebi.ac.uk/ena/data/view/AY339422
EMBL	AY339423	http://www.ebi.ac.uk/ena/data/view/AY339423
EMBL	AY339424	http://www.ebi.ac.uk/ena/data/view/AY339424
EMBL	AY339425	http://www.ebi.ac.uk/ena/data/view/AY339425
EMBL	AY339426	http://www.ebi.ac.uk/ena/data/view/AY339426
EMBL	AY339427	http://www.ebi.ac.uk/ena/data/view/AY339427
EMBL	AY339428	http://www.ebi.ac.uk/ena/data/view/AY339428
EMBL	AY339429	http://www.ebi.ac.uk/ena/data/view/AY339429
EMBL	AY339430	http://www.ebi.ac.uk/ena/data/view/AY339430
EMBL	AY339431	http://www.ebi.ac.uk/ena/data/view/AY339431
EMBL	AY339432	http://www.ebi.ac.uk/ena/data/view/AY339432
EMBL	AY339433	http://www.ebi.ac.uk/ena/data/view/AY339433
EMBL	AY339434	http://www.ebi.ac.uk/ena/data/view/AY339434
EMBL	AY339435	http://www.ebi.ac.uk/ena/data/view/AY339435
EMBL	AY339436	http://www.ebi.ac.uk/ena/data/view/AY339436
EMBL	AY339437	http://www.ebi.ac.uk/ena/data/view/AY339437
EMBL	AY339438	http://www.ebi.ac.uk/ena/data/view/AY339438
EMBL	AY339439	http://www.ebi.ac.uk/ena/data/view/AY339439
EMBL	AY339440	http://www.ebi.ac.uk/ena/data/view/AY339440
EMBL	AY339441	http://www.ebi.ac.uk/ena/data/view/AY339441
EMBL	AY339442	http://www.ebi.ac.uk/ena/data/view/AY339442
EMBL	AY339443	http://www.ebi.ac.uk/ena/data/view/AY339443
EMBL	AY339444	http://www.ebi.ac.uk/ena/data/view/AY339444
EMBL	AY339445	http://www.ebi.ac.uk/ena/data/view/AY339445
EMBL	AY339446	http://www.ebi.ac.uk/ena/data/view/AY339446
EMBL	AY339447	http://www.ebi.ac.uk/ena/data/view/AY339447
EMBL	AY339448	http://www.ebi.ac.uk/ena/data/view/AY339448
EMBL	AY339449	http://www.ebi.ac.uk/ena/data/view/AY339449
EMBL	AY339450	http://www.ebi.ac.uk/ena/data/view/AY339450
EMBL	AY339451	http://www.ebi.ac.uk/ena/data/view/AY339451
EMBL	AY339452	http://www.ebi.ac.uk/ena/data/view/AY339452
EMBL	AY339453	http://www.ebi.ac.uk/ena/data/view/AY339453
EMBL	AY339454	http://www.ebi.ac.uk/ena/data/view/AY339454
EMBL	AY339455	http://www.ebi.ac.uk/ena/data/view/AY339455
EMBL	AY339456	http://www.ebi.ac.uk/ena/data/view/AY339456
EMBL	AY339457	http://www.ebi.ac.uk/ena/data/view/AY339457
EMBL	AY339458	http://www.ebi.ac.uk/ena/data/view/AY339458
EMBL	AY339459	http://www.ebi.ac.uk/ena/data/view/AY339459
EMBL	AY339460	http://www.ebi.ac.uk/ena/data/view/AY339460
EMBL	AY339461	http://www.ebi.ac.uk/ena/data/view/AY339461
EMBL	AY339462	http://www.ebi.ac.uk/ena/data/view/AY339462
EMBL	AY339463	http://www.ebi.ac.uk/ena/data/view/AY339463
EMBL	AY339464	http://www.ebi.ac.uk/ena/data/view/AY339464
EMBL	AY339465	http://www.ebi.ac.uk/ena/data/view/AY339465
EMBL	AY339466	http://www.ebi.ac.uk/ena/data/view/AY339466
EMBL	AY339467	http://www.ebi.ac.uk/ena/data/view/AY339467
EMBL	AY339468	http://www.ebi.ac.uk/ena/data/view/AY339468
EMBL	AY339469	http://www.ebi.ac.uk/ena/data/view/AY339469
EMBL	AY339470	http://www.ebi.ac.uk/ena/data/view/AY339470
EMBL	AY339471	http://www.ebi.ac.uk/ena/data/view/AY339471
EMBL	AY339472	http://www.ebi.ac.uk/ena/data/view/AY339472
EMBL	AY339473	http://www.ebi.ac.uk/ena/data/view/AY339473
EMBL	AY339474	http://www.ebi.ac.uk/ena/data/view/AY339474
EMBL	AY339475	http://www.ebi.ac.uk/ena/data/view/AY339475
EMBL	AY339476	http://www.ebi.ac.uk/ena/data/view/AY339476
EMBL	AY339477	http://www.ebi.ac.uk/ena/data/view/AY339477
EMBL	AY339478	http://www.ebi.ac.uk/ena/data/view/AY339478
EMBL	AY339479	http://www.ebi.ac.uk/ena/data/view/AY339479
EMBL	AY339480	http://www.ebi.ac.uk/ena/data/view/AY339480
EMBL	AY339481	http://www.ebi.ac.uk/ena/data/view/AY339481
EMBL	AY339482	http://www.ebi.ac.uk/ena/data/view/AY339482
EMBL	AY339483	http://www.ebi.ac.uk/ena/data/view/AY339483
EMBL	AY339484	http://www.ebi.ac.uk/ena/data/view/AY339484
EMBL	AY339485	http://www.ebi.ac.uk/ena/data/view/AY339485
EMBL	AY339486	http://www.ebi.ac.uk/ena/data/view/AY339486
EMBL	AY339487	http://www.ebi.ac.uk/ena/data/view/AY339487
EMBL	AY339488	http://www.ebi.ac.uk/ena/data/view/AY339488
EMBL	AY339489	http://www.ebi.ac.uk/ena/data/view/AY339489
EMBL	AY339490	http://www.ebi.ac.uk/ena/data/view/AY339490
EMBL	AY339491	http://www.ebi.ac.uk/ena/data/view/AY339491
EMBL	AY339492	http://www.ebi.ac.uk/ena/data/view/AY339492
EMBL	AY339493	http://www.ebi.ac.uk/ena/data/view/AY339493
EMBL	AY339494	http://www.ebi.ac.uk/ena/data/view/AY339494
EMBL	AY339495	http://www.ebi.ac.uk/ena/data/view/AY339495
EMBL	AY339496	http://www.ebi.ac.uk/ena/data/view/AY339496
EMBL	AY339497	http://www.ebi.ac.uk/ena/data/view/AY339497
EMBL	AY339498	http://www.ebi.ac.uk/ena/data/view/AY339498
EMBL	AY339499	http://www.ebi.ac.uk/ena/data/view/AY339499
EMBL	AY339500	http://www.ebi.ac.uk/ena/data/view/AY339500
EMBL	AY339501	http://www.ebi.ac.uk/ena/data/view/AY339501
EMBL	AY339502	http://www.ebi.ac.uk/ena/data/view/AY339502
EMBL	AY339503	http://www.ebi.ac.uk/ena/data/view/AY339503
EMBL	AY339504	http://www.ebi.ac.uk/ena/data/view/AY339504
EMBL	AY339505	http://www.ebi.ac.uk/ena/data/view/AY339505
EMBL	AY339506	http://www.ebi.ac.uk/ena/data/view/AY339506
EMBL	AY339507	http://www.ebi.ac.uk/ena/data/view/AY339507
EMBL	AY339508	http://www.ebi.ac.uk/ena/data/view/AY339508
EMBL	AY339509	http://www.ebi.ac.uk/ena/data/view/AY339509
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EMBL	AY495284	http://www.ebi.ac.uk/ena/data/view/AY495284
EMBL	AY495285	http://www.ebi.ac.uk/ena/data/view/AY495285
EMBL	AY495286	http://www.ebi.ac.uk/ena/data/view/AY495286
EMBL	AY495287	http://www.ebi.ac.uk/ena/data/view/AY495287
EMBL	AY495288	http://www.ebi.ac.uk/ena/data/view/AY495288
EMBL	AY495289	http://www.ebi.ac.uk/ena/data/view/AY495289
EMBL	AY495290	http://www.ebi.ac.uk/ena/data/view/AY495290
EMBL	AY495291	http://www.ebi.ac.uk/ena/data/view/AY495291
EMBL	AY495292	http://www.ebi.ac.uk/ena/data/view/AY495292
EMBL	AY495293	http://www.ebi.ac.uk/ena/data/view/AY495293
EMBL	AY495294	http://www.ebi.ac.uk/ena/data/view/AY495294
EMBL	AY495295	http://www.ebi.ac.uk/ena/data/view/AY495295
EMBL	AY495296	http://www.ebi.ac.uk/ena/data/view/AY495296
EMBL	AY495297	http://www.ebi.ac.uk/ena/data/view/AY495297
EMBL	AY495298	http://www.ebi.ac.uk/ena/data/view/AY495298
EMBL	AY495299	http://www.ebi.ac.uk/ena/data/view/AY495299
EMBL	AY495301	http://www.ebi.ac.uk/ena/data/view/AY495301
EMBL	AY495302	http://www.ebi.ac.uk/ena/data/view/AY495302
EMBL	AY495304	http://www.ebi.ac.uk/ena/data/view/AY495304
EMBL	AY495305	http://www.ebi.ac.uk/ena/data/view/AY495305
EMBL	AY495306	http://www.ebi.ac.uk/ena/data/view/AY495306
EMBL	AY495307	http://www.ebi.ac.uk/ena/data/view/AY495307
EMBL	AY495308	http://www.ebi.ac.uk/ena/data/view/AY495308
EMBL	AY495309	http://www.ebi.ac.uk/ena/data/view/AY495309
EMBL	AY495310	http://www.ebi.ac.uk/ena/data/view/AY495310
EMBL	AY495311	http://www.ebi.ac.uk/ena/data/view/AY495311
EMBL	AY495312	http://www.ebi.ac.uk/ena/data/view/AY495312
EMBL	AY495313	http://www.ebi.ac.uk/ena/data/view/AY495313
EMBL	AY495314	http://www.ebi.ac.uk/ena/data/view/AY495314
EMBL	AY495315	http://www.ebi.ac.uk/ena/data/view/AY495315
EMBL	AY495316	http://www.ebi.ac.uk/ena/data/view/AY495316
EMBL	AY495317	http://www.ebi.ac.uk/ena/data/view/AY495317
EMBL	AY495318	http://www.ebi.ac.uk/ena/data/view/AY495318
EMBL	AY495319	http://www.ebi.ac.uk/ena/data/view/AY495319
EMBL	AY495320	http://www.ebi.ac.uk/ena/data/view/AY495320
EMBL	AY495322	http://www.ebi.ac.uk/ena/data/view/AY495322
EMBL	AY495323	http://www.ebi.ac.uk/ena/data/view/AY495323
EMBL	AY495324	http://www.ebi.ac.uk/ena/data/view/AY495324
EMBL	AY495325	http://www.ebi.ac.uk/ena/data/view/AY495325
EMBL	AY495326	http://www.ebi.ac.uk/ena/data/view/AY495326
EMBL	AY495327	http://www.ebi.ac.uk/ena/data/view/AY495327
EMBL	AY495328	http://www.ebi.ac.uk/ena/data/view/AY495328
EMBL	AY495329	http://www.ebi.ac.uk/ena/data/view/AY495329
EMBL	AY495330	http://www.ebi.ac.uk/ena/data/view/AY495330
EMBL	D38112	http://www.ebi.ac.uk/ena/data/view/D38112
EMBL	J01415	http://www.ebi.ac.uk/ena/data/view/J01415
EMBL	V00662	http://www.ebi.ac.uk/ena/data/view/V00662
Ensembl	ENST00000361851	http://www.ensembl.org/id/ENST00000361851
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000276
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005753	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005753
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015078	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015078
GO_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GO_process	GO:0006754	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006754
GO_process	GO:0042776	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042776
GO_process	GO:0055093	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055093
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	MT-ATP8	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=MT-ATP8
GeneID	4509	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4509
GeneTree	ENSGT00390000008771	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000008771
H-InvDB	HIX0028087	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0028087
HGNC	HGNC:7415	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:7415
HOGENOM	HOG000251628	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000251628&db=HOGENOM6
HOVERGEN	HBG017400	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG017400&db=HOVERGEN
HPA	HPA053976	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA053976
InParanoid	P03928	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P03928
IntAct	P03928	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P03928*
InterPro	IPR001421	http://www.ebi.ac.uk/interpro/entry/IPR001421
Jabion	4509	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=4509
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Disease	H01355	http://www.genome.jp/dbget-bin/www_bget?H01355
KEGG_Disease	H01369	http://www.genome.jp/dbget-bin/www_bget?H01369
KEGG_Gene	hsa:4509	http://www.genome.jp/dbget-bin/www_bget?hsa:4509
KEGG_Orthology	KO:K02125	http://www.genome.jp/dbget-bin/www_bget?KO:K02125
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	516070	http://www.ncbi.nlm.nih.gov/omim/516070
OMA	LDTSTWF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LDTSTWF
Orphanet	155	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=155
Orphanet	397750	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=397750
Orphanet	480	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=480
OrthoDB	EOG091G1977	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G1977
PSORT	swissprot:ATP8_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ATP8_HUMAN
PSORT-B	swissprot:ATP8_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ATP8_HUMAN
PSORT2	swissprot:ATP8_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ATP8_HUMAN
Pfam	PF00895	http://pfam.xfam.org/family/PF00895
PharmGKB	PA31222	http://www.pharmgkb.org/do/serve?objId=PA31222&objCls=Gene
Phobius	swissprot:ATP8_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ATP8_HUMAN
PhylomeDB	P03928	http://phylomedb.org/?seqid=P03928
ProteinModelPortal	P03928	http://www.proteinmodelportal.org/query/uniprot/P03928
PubMed	11130070	http://www.ncbi.nlm.nih.gov/pubmed/11130070
PubMed	12840039	http://www.ncbi.nlm.nih.gov/pubmed/12840039
PubMed	12949126	http://www.ncbi.nlm.nih.gov/pubmed/12949126
PubMed	14760490	http://www.ncbi.nlm.nih.gov/pubmed/14760490
PubMed	1757091	http://www.ncbi.nlm.nih.gov/pubmed/1757091
PubMed	19188198	http://www.ncbi.nlm.nih.gov/pubmed/19188198
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	7219534	http://www.ncbi.nlm.nih.gov/pubmed/7219534
PubMed	7530363	http://www.ncbi.nlm.nih.gov/pubmed/7530363
PubMed	9461455	http://www.ncbi.nlm.nih.gov/pubmed/9461455
Reactome	R-HSA-163210	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-163210
RefSeq	YP_003024030	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_003024030
STRING	9606.ENSP00000355265	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000355265&targetmode=cogs
UniProtKB	ATP8_HUMAN	http://www.uniprot.org/uniprot/ATP8_HUMAN
UniProtKB-AC	P03928	http://www.uniprot.org/uniprot/P03928
charge	swissprot:ATP8_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ATP8_HUMAN
eggNOG	ENOG410J587	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410J587
eggNOG	ENOG411154N	http://eggnogapi.embl.de/nog_data/html/tree/ENOG411154N
epestfind	swissprot:ATP8_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ATP8_HUMAN
garnier	swissprot:ATP8_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ATP8_HUMAN
helixturnhelix	swissprot:ATP8_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATP8_HUMAN
hmoment	swissprot:ATP8_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ATP8_HUMAN
iep	swissprot:ATP8_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ATP8_HUMAN
inforesidue	swissprot:ATP8_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ATP8_HUMAN
neXtProt	NX_P03928	http://www.nextprot.org/db/entry/NX_P03928
octanol	swissprot:ATP8_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ATP8_HUMAN
pepcoil	swissprot:ATP8_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ATP8_HUMAN
pepdigest	swissprot:ATP8_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ATP8_HUMAN
pepinfo	swissprot:ATP8_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ATP8_HUMAN
pepnet	swissprot:ATP8_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ATP8_HUMAN
pepstats	swissprot:ATP8_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ATP8_HUMAN
pepwheel	swissprot:ATP8_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ATP8_HUMAN
pepwindow	swissprot:ATP8_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ATP8_HUMAN
sigcleave	swissprot:ATP8_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ATP8_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNH4_HUMAN	Brain-specific eag-like channel 2
# AltName	KCNH4_HUMAN	Ether-a-go-go-like potassium channel 1
# AltName	KCNH4_HUMAN	Voltage-gated potassium channel subunit Kv12.3
# DOMAIN	KCNH4_HUMAN	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. 
# Ensembl	ENST00000264661	ENSP00000264661; ENSG00000089558
# Ensembl	ENST00000607371	ENSP00000475564; ENSG00000089558
# FUNCTION	KCNH4_HUMAN	Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows no inactivation. Channel properties may be modulated by cAMP and subunit assembly. 
# GO_component	GO:0005622	intracellular; IEA:GOC.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008076	voltage-gated potassium channel complex; TAS:ProtInc.
# GO_function	GO:0000155	phosphorelay sensor kinase activity; IEA:InterPro.
# GO_function	GO:0005249	voltage-gated potassium channel activity; TAS:ProtInc.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0042391	regulation of membrane potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005622	intracellular
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0016301	kinase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Gene3D	2.60.120.10	-; 1.
# Genevisible	Q9UQ05	HS
# HGNC	HGNC:6253	KCNH4
# InterPro	IPR000014	PAS
# InterPro	IPR000595	cNMP-bd_dom
# InterPro	IPR000700	PAS-assoc_C
# InterPro	IPR001610	PAC
# InterPro	IPR003938	K_chnl_volt-dep_EAG/ELK/ERG
# InterPro	IPR003950	K_chnl_volt-dep_ELK
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR014710	RmlC-like_jellyroll
# InterPro	IPR018490	cNMP-bd-like
# KEGG_Brite	ko04040	Ion channels
# MIM	604528	gene
# Organism	KCNH4_HUMAN	Homo sapiens (Human)
# PRINTS	PR01463	EAGCHANLFMLY
# PRINTS	PR01465	ELKCHANNEL
# PROSITE	PS50042	CNMP_BINDING_3
# PROSITE	PS50112	PAS
# PROSITE	PS50113	PAC
# Pfam	PF00520	Ion_trans
# Pfam	PF13426	PAS_9
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# RecName	KCNH4_HUMAN	Potassium voltage-gated channel subfamily H member 4
# RefSeq	NP_036417	NM_012285.2
# RefSeq	XP_016879889	XM_017024400.1
# SIMILARITY	Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.3/KCNH4 sub-subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 PAC (PAS-associated C-terminal) domain. {ECO:0000255|PROSITE-ProRule	PRU00141}. 
# SIMILARITY	Contains 1 PAS (PER-ARNT-SIM) domain. {ECO:0000255|PROSITE-ProRule	PRU00140}.
# SIMILARITY	Contains 1 cyclic nucleotide-binding domain. {ECO:0000255|PROSITE-ProRule	PRU00060}. 
# SMART	SM00086	PAC
# SMART	SM00100	cNMP
# SUBCELLULAR LOCATION	KCNH4_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	KCNH4_HUMAN	The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. 
# SUPFAM	SSF51206	SSF51206
# SUPFAM	SSF55785	SSF55785
# TIGRFAMs	TIGR00229	sensory_box
# TISSUE SPECIFICITY	KCNH4_HUMAN	Detected only in brain, in particular in the telencephalon. Detected in putamen and caudate nucleus, and at lower levels in cerebral cortex, occipital and hippocampus. 
# UCSC	uc002hzb	human
# eggNOG	ENOG410XPSE	LUCA
# eggNOG	KOG0498	Eukaryota
BLAST	swissprot:KCNH4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNH4_HUMAN
BioCyc	ZFISH:ENSG00000089558-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000089558-MONOMER
COXPRESdb	23415	http://coxpresdb.jp/data/gene/23415.shtml
CleanEx	HS_KCNH4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNH4
DOI	10.1074/jbc.274.35.25018	http://dx.doi.org/10.1074/jbc.274.35.25018
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
EMBL	AB022698	http://www.ebi.ac.uk/ena/data/view/AB022698
Ensembl	ENST00000264661	http://www.ensembl.org/id/ENST00000264661
Ensembl	ENST00000607371	http://www.ensembl.org/id/ENST00000607371
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_function	GO:0000155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0016301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	2.60.120.10	http://www.cathdb.info/version/latest/superfamily/2.60.120.10
GeneCards	KCNH4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNH4
GeneID	23415	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23415
GeneTree	ENSGT00760000118772	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118772
HGNC	HGNC:6253	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6253
HOGENOM	HOG000230794	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230794&db=HOGENOM6
HOVERGEN	HBG052232	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052232&db=HOVERGEN
InParanoid	Q9UQ05	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UQ05
InterPro	IPR000014	http://www.ebi.ac.uk/interpro/entry/IPR000014
InterPro	IPR000595	http://www.ebi.ac.uk/interpro/entry/IPR000595
InterPro	IPR000700	http://www.ebi.ac.uk/interpro/entry/IPR000700
InterPro	IPR001610	http://www.ebi.ac.uk/interpro/entry/IPR001610
InterPro	IPR003938	http://www.ebi.ac.uk/interpro/entry/IPR003938
InterPro	IPR003950	http://www.ebi.ac.uk/interpro/entry/IPR003950
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR014710	http://www.ebi.ac.uk/interpro/entry/IPR014710
InterPro	IPR018490	http://www.ebi.ac.uk/interpro/entry/IPR018490
Jabion	23415	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=23415
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:23415	http://www.genome.jp/dbget-bin/www_bget?hsa:23415
KEGG_Orthology	KO:K04907	http://www.genome.jp/dbget-bin/www_bget?KO:K04907
MIM	604528	http://www.ncbi.nlm.nih.gov/omim/604528
OMA	VPKAVWD	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VPKAVWD
OrthoDB	EOG091G0OXR	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0OXR
PRINTS	PR01463	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01463
PRINTS	PR01465	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01465
PROSITE	PS50042	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50042
PROSITE	PS50112	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50112
PROSITE	PS50113	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50113
PSORT	swissprot:KCNH4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNH4_HUMAN
PSORT-B	swissprot:KCNH4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNH4_HUMAN
PSORT2	swissprot:KCNH4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNH4_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF13426	http://pfam.xfam.org/family/PF13426
PharmGKB	PA30039	http://www.pharmgkb.org/do/serve?objId=PA30039&objCls=Gene
Phobius	swissprot:KCNH4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNH4_HUMAN
PhylomeDB	Q9UQ05	http://phylomedb.org/?seqid=Q9UQ05
ProteinModelPortal	Q9UQ05	http://www.proteinmodelportal.org/query/uniprot/Q9UQ05
PubMed	10455180	http://www.ncbi.nlm.nih.gov/pubmed/10455180
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
RefSeq	NP_036417	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_036417
RefSeq	XP_016879889	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016879889
SMART	SM00086	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00086
SMART	SM00100	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00100
SMR	Q9UQ05	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9UQ05
STRING	9606.ENSP00000264661	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000264661&targetmode=cogs
SUPFAM	SSF51206	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51206
SUPFAM	SSF55785	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55785
TIGRFAMs	TIGR00229	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00229
UCSC	uc002hzb	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002hzb&org=rat
UniGene	Hs.304081	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.304081
UniProtKB	KCNH4_HUMAN	http://www.uniprot.org/uniprot/KCNH4_HUMAN
UniProtKB-AC	Q9UQ05	http://www.uniprot.org/uniprot/Q9UQ05
charge	swissprot:KCNH4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNH4_HUMAN
eggNOG	ENOG410XPSE	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPSE
eggNOG	KOG0498	http://eggnogapi.embl.de/nog_data/html/tree/KOG0498
epestfind	swissprot:KCNH4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNH4_HUMAN
garnier	swissprot:KCNH4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNH4_HUMAN
helixturnhelix	swissprot:KCNH4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNH4_HUMAN
hmoment	swissprot:KCNH4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNH4_HUMAN
iep	swissprot:KCNH4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNH4_HUMAN
inforesidue	swissprot:KCNH4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNH4_HUMAN
neXtProt	NX_Q9UQ05	http://www.nextprot.org/db/entry/NX_Q9UQ05
octanol	swissprot:KCNH4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNH4_HUMAN
pepcoil	swissprot:KCNH4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNH4_HUMAN
pepdigest	swissprot:KCNH4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNH4_HUMAN
pepinfo	swissprot:KCNH4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNH4_HUMAN
pepnet	swissprot:KCNH4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNH4_HUMAN
pepstats	swissprot:KCNH4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNH4_HUMAN
pepwheel	swissprot:KCNH4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNH4_HUMAN
pepwindow	swissprot:KCNH4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNH4_HUMAN
sigcleave	swissprot:KCNH4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNH4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ANKH_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9HCJ1-1; Sequence=Displayed; Name=2; IsoId=Q9HCJ1-2; Sequence=VSP_055824; Note=No experimental confirmation available.; 
# BioGrid	121103	2
# CCDS	CCDS3885	-. [Q9HCJ1-1]
# ChiTaRS	ANKH	human
# DISEASE	ANKH_HUMAN	Chondrocalcinosis 2 (CCAL2) [MIM 118600]  Chondrocalcinosis is a common cause of joint pain and arthritis caused by calcium deposition in articular cartilage and the presence of calcium hypophosphate crystals in synovial fluid, cartilage and periarticular soft tissue. CCAL2 inheritance is autosomal dominant. {ECO 0000269|PubMed 12297987, ECO 0000269|PubMed 12297989, ECO 0000269|PubMed 13130483}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ANKH_HUMAN	Craniometaphyseal dysplasia, autosomal dominant (CMDD) [MIM 123000]  An osteochondrodysplasia characterized by hyperostosis and sclerosis of the craniofacial bones associated with abnormal modeling of the metaphyses. Sclerosis of the skull may lead to asymmetry of the mandible, as well as to cranial nerve compression, that may finally result in hearing loss and facial palsy. {ECO 0000269|PubMed 11326272, ECO 0000269|PubMed 11326338}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000284268	ENSP00000284268; ENSG00000154122. [Q9HCJ1-1]
# ExpressionAtlas	Q9HCJ1	baseline and differential
# FUNCTION	ANKH_HUMAN	Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter. 
# GO_component	GO:0005886	plasma membrane; ISS:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; ISS:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IDA:UniProtKB.
# GO_component	GO:0019867	outer membrane; TAS:UniProtKB.
# GO_function	GO:0005315	inorganic phosphate transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015114	phosphate ion transmembrane transporter activity; IEA:InterPro.
# GO_function	GO:0030504	inorganic diphosphate transmembrane transporter activity; IDA:UniProtKB.
# GO_process	GO:0001501	skeletal system development; NAS:UniProtKB.
# GO_process	GO:0007626	locomotory behavior; NAS:UniProtKB.
# GO_process	GO:0030500	regulation of bone mineralization; ISS:UniProtKB.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9HCJ1	HS
# HGNC	HGNC:15492	ANKH
# InterPro	IPR009887	ANKH
# KEGG_Disease	H00491	[Skeletal dysplasia] Craniometaphyseal dysplasia
# KEGG_Disease	H01236	[Musculoskeletal disease] Familial articular chondrocalcinosis
# MIM	118600	phenotype
# MIM	123000	phenotype
# MIM	605145	gene
# Organism	ANKH_HUMAN	Homo sapiens (Human)
# Orphanet	1416	Familial calcium pyrophosphate deposition
# Orphanet	1522	Craniometaphyseal dysplasia
# Pfam	PF07260	ANKH
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-5223345	Miscellaneous transport and binding events
# RecName	ANKH_HUMAN	Progressive ankylosis protein homolog
# RefSeq	NP_473368	NM_054027.4. [Q9HCJ1-1]
# SEQUENCE CAUTION	Sequence=BAB13407.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the ANKH family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	ANKH_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	2.A.66.9	the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily
# TISSUE SPECIFICITY	ANKH_HUMAN	Found in osteoblasts from mandibular bone and from iliac bone; not detected in osteoclastic cells. 
# UCSC	uc003jfm	human. [Q9HCJ1-1]
# eggNOG	ENOG410IH1E	Eukaryota
# eggNOG	ENOG410ZCHM	LUCA
BLAST	swissprot:ANKH_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ANKH_HUMAN
BioCyc	ZFISH:ENSG00000154122-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000154122-MONOMER
COXPRESdb	56172	http://coxpresdb.jp/data/gene/56172.shtml
CleanEx	HS_ANKH	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ANKH
DOI	10.1002/art.11133	http://dx.doi.org/10.1002/art.11133
DOI	10.1038/88236	http://dx.doi.org/10.1038/88236
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1086/320612	http://dx.doi.org/10.1086/320612
DOI	10.1086/343053	http://dx.doi.org/10.1086/343053
DOI	10.1086/343054	http://dx.doi.org/10.1086/343054
DOI	10.1093/dnares/7.4.271	http://dx.doi.org/10.1093/dnares/7.4.271
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.289.5477.265	http://dx.doi.org/10.1126/science.289.5477.265
EMBL	AB046801	http://www.ebi.ac.uk/ena/data/view/AB046801
EMBL	AC010491	http://www.ebi.ac.uk/ena/data/view/AC010491
EMBL	AC016575	http://www.ebi.ac.uk/ena/data/view/AC016575
EMBL	AC025456	http://www.ebi.ac.uk/ena/data/view/AC025456
EMBL	AF274753	http://www.ebi.ac.uk/ena/data/view/AF274753
EMBL	AK001799	http://www.ebi.ac.uk/ena/data/view/AK001799
EMBL	AK315012	http://www.ebi.ac.uk/ena/data/view/AK315012
EMBL	AY358503	http://www.ebi.ac.uk/ena/data/view/AY358503
EMBL	BC009835	http://www.ebi.ac.uk/ena/data/view/BC009835
EMBL	BC014526	http://www.ebi.ac.uk/ena/data/view/BC014526
EMBL	CH471102	http://www.ebi.ac.uk/ena/data/view/CH471102
EMBL	CH471102	http://www.ebi.ac.uk/ena/data/view/CH471102
Ensembl	ENST00000284268	http://www.ensembl.org/id/ENST00000284268
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0019867	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019867
GO_function	GO:0005315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005315
GO_function	GO:0015114	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015114
GO_function	GO:0030504	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030504
GO_process	GO:0001501	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001501
GO_process	GO:0007626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007626
GO_process	GO:0030500	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030500
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ANKH	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ANKH
GeneID	56172	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56172
GeneTree	ENSGT00390000012189	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000012189
HGNC	HGNC:15492	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:15492
HOGENOM	HOG000033943	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000033943&db=HOGENOM6
HOVERGEN	HBG018728	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG018728&db=HOVERGEN
HPA	HPA068104	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA068104
InParanoid	Q9HCJ1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9HCJ1
IntAct	Q9HCJ1	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9HCJ1*
InterPro	IPR009887	http://www.ebi.ac.uk/interpro/entry/IPR009887
Jabion	56172	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=56172
KEGG_Disease	H00491	http://www.genome.jp/dbget-bin/www_bget?H00491
KEGG_Disease	H01236	http://www.genome.jp/dbget-bin/www_bget?H01236
KEGG_Gene	hsa:56172	http://www.genome.jp/dbget-bin/www_bget?hsa:56172
MIM	118600	http://www.ncbi.nlm.nih.gov/omim/118600
MIM	123000	http://www.ncbi.nlm.nih.gov/omim/123000
MIM	605145	http://www.ncbi.nlm.nih.gov/omim/605145
OMA	YMGVHGA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YMGVHGA
Orphanet	1416	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1416
Orphanet	1522	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1522
OrthoDB	EOG091G0587	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0587
PSORT	swissprot:ANKH_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ANKH_HUMAN
PSORT-B	swissprot:ANKH_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ANKH_HUMAN
PSORT2	swissprot:ANKH_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ANKH_HUMAN
Pfam	PF07260	http://pfam.xfam.org/family/PF07260
PharmGKB	PA24801	http://www.pharmgkb.org/do/serve?objId=PA24801&objCls=Gene
Phobius	swissprot:ANKH_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ANKH_HUMAN
PhylomeDB	Q9HCJ1	http://phylomedb.org/?seqid=Q9HCJ1
ProteinModelPortal	Q9HCJ1	http://www.proteinmodelportal.org/query/uniprot/Q9HCJ1
PubMed	10894769	http://www.ncbi.nlm.nih.gov/pubmed/10894769
PubMed	10997877	http://www.ncbi.nlm.nih.gov/pubmed/10997877
PubMed	11326272	http://www.ncbi.nlm.nih.gov/pubmed/11326272
PubMed	11326338	http://www.ncbi.nlm.nih.gov/pubmed/11326338
PubMed	12297987	http://www.ncbi.nlm.nih.gov/pubmed/12297987
PubMed	12297989	http://www.ncbi.nlm.nih.gov/pubmed/12297989
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	13130483	http://www.ncbi.nlm.nih.gov/pubmed/13130483
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-5223345	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5223345
RefSeq	NP_473368	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_473368
STRING	9606.ENSP00000284268	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000284268&targetmode=cogs
TCDB	2.A.66.9	http://www.tcdb.org/search/result.php?tc=2.A.66.9
UCSC	uc003jfm	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003jfm&org=rat
UniGene	Hs.156727	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.156727
UniProtKB	ANKH_HUMAN	http://www.uniprot.org/uniprot/ANKH_HUMAN
UniProtKB-AC	Q9HCJ1	http://www.uniprot.org/uniprot/Q9HCJ1
charge	swissprot:ANKH_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ANKH_HUMAN
eggNOG	ENOG410IH1E	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IH1E
eggNOG	ENOG410ZCHM	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZCHM
epestfind	swissprot:ANKH_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ANKH_HUMAN
garnier	swissprot:ANKH_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ANKH_HUMAN
helixturnhelix	swissprot:ANKH_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ANKH_HUMAN
hmoment	swissprot:ANKH_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ANKH_HUMAN
iep	swissprot:ANKH_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ANKH_HUMAN
inforesidue	swissprot:ANKH_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ANKH_HUMAN
neXtProt	NX_Q9HCJ1	http://www.nextprot.org/db/entry/NX_Q9HCJ1
octanol	swissprot:ANKH_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ANKH_HUMAN
pepcoil	swissprot:ANKH_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ANKH_HUMAN
pepdigest	swissprot:ANKH_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ANKH_HUMAN
pepinfo	swissprot:ANKH_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ANKH_HUMAN
pepnet	swissprot:ANKH_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ANKH_HUMAN
pepstats	swissprot:ANKH_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ANKH_HUMAN
pepwheel	swissprot:ANKH_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ANKH_HUMAN
pepwindow	swissprot:ANKH_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ANKH_HUMAN
sigcleave	swissprot:ANKH_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ANKH_HUMAN
## Database	ID	URL or Descriptions
# AltName	ACH10_HUMAN	Nicotinic acetylcholine receptor subunit alpha-10
# DrugBank	DB00184	Nicotine
# DrugBank	DB00202	Succinylcholine
# DrugBank	DB00333	Methadone
# DrugBank	DB00674	Galantamine
# DrugBank	DB00898	Ethanol
# DrugBank	DB01090	Pentolinium
# DrugBank	DB01116	Trimethaphan
# DrugBank	DB01161	Chloroprocaine
# Ensembl	ENST00000250699	ENSP00000250699; ENSG00000129749
# ExpressionAtlas	Q9GZZ6	baseline and differential
# FUNCTION	ACH10_HUMAN	Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. {ECO 0000269|PubMed 11752216}. 
# GO_component	GO:0005892	acetylcholine-gated channel complex; IBA:GO_Central.
# GO_component	GO:0016020	membrane; TAS:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030424	axon; IEA:Ensembl.
# GO_component	GO:0043204	perikaryon; IEA:Ensembl.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0004889	acetylcholine-activated cation-selective channel activity; IEA:Ensembl.
# GO_function	GO:0005102	receptor binding; TAS:UniProtKB.
# GO_function	GO:0005262	calcium channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0042166	acetylcholine binding; IBA:GO_Central.
# GO_process	GO:0007165	signal transduction; IEA:GOC.
# GO_process	GO:0007204	positive regulation of cytosolic calcium ion concentration; IGI:MGI.
# GO_process	GO:0007271	synaptic transmission, cholinergic; TAS:UniProtKB.
# GO_process	GO:0042127	regulation of cell proliferation; TAS:UniProtKB.
# GO_process	GO:0042472	inner ear morphogenesis; IEA:Ensembl.
# GO_process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0050877	neurological system process
# Gene3D	1.20.120.370	-; 2.
# Gene3D	2.70.170.10	-; 1.
# Genevisible	Q9GZZ6	HS
# HGNC	HGNC:13800	CHRNA10
# InterPro	IPR002394	Nicotinic_acetylcholine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# InterPro	IPR027361	Acetylcholine_rcpt_TM
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# MIM	606372	gene
# MISCELLANEOUS	ACH10_HUMAN	The heterooligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic acetylcholine receptor antagonist). 
# Organism	ACH10_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR18945	PTHR18945
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00254	NICOTINICR
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb; 2
# Proteomes	UP000005640	Chromosome 11
# RecName	ACH10_HUMAN	Neuronal acetylcholine receptor subunit alpha-10
# RefSeq	NP_001289963	NM_001303034.1
# RefSeq	NP_001289964	NM_001303035.1
# RefSeq	NP_065135	NM_020402.3
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 10/CHRNA10 sub-subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	ACH10_HUMAN	Cell junction, synapse, postsynaptic cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUBUNIT	ACH10_HUMAN	Forms heterooligomeric channels in conjunction with CHRNA9. The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 heterooligomers. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TIGRFAMs	TIGR00860	LIC
# TISSUE SPECIFICITY	ACH10_HUMAN	Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes. {ECO 0000269|PubMed 11752216, ECO 0000269|PubMed 15531379}. 
# UCSC	uc001lyf	human
# eggNOG	ENOG410XQGR	LUCA
# eggNOG	KOG3645	Eukaryota
BLAST	swissprot:ACH10_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ACH10_HUMAN
BioCyc	ZFISH:ENSG00000129749-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000129749-MONOMER
COXPRESdb	57053	http://coxpresdb.jp/data/gene/57053.shtml
CleanEx	HS_CHRNA10	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CHRNA10
DOI	10.1006/geno.2000.6503	http://dx.doi.org/10.1006/geno.2000.6503
DOI	10.1016/j.lfs.2004.05.031	http://dx.doi.org/10.1016/j.lfs.2004.05.031
DOI	10.1124/mol.61.1.150	http://dx.doi.org/10.1124/mol.61.1.150
DrugBank	DB00184	http://www.drugbank.ca/drugs/DB00184
DrugBank	DB00202	http://www.drugbank.ca/drugs/DB00202
DrugBank	DB00333	http://www.drugbank.ca/drugs/DB00333
DrugBank	DB00674	http://www.drugbank.ca/drugs/DB00674
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01090	http://www.drugbank.ca/drugs/DB01090
DrugBank	DB01116	http://www.drugbank.ca/drugs/DB01116
DrugBank	DB01161	http://www.drugbank.ca/drugs/DB01161
EMBL	AF199235	http://www.ebi.ac.uk/ena/data/view/AF199235
EMBL	AF327367	http://www.ebi.ac.uk/ena/data/view/AF327367
EMBL	AJ278118	http://www.ebi.ac.uk/ena/data/view/AJ278118
EMBL	AJ295237	http://www.ebi.ac.uk/ena/data/view/AJ295237
Ensembl	ENST00000250699	http://www.ensembl.org/id/ENST00000250699
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005892	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005892
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030424	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030424
GO_component	GO:0043204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043204
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0004889	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004889
GO_function	GO:0005102	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005102
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0042166	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042166
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007204
GO_process	GO:0007271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007271
GO_process	GO:0042127	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042127
GO_process	GO:0042472	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042472
GO_process	GO:0050910	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050910
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
Gene3D	1.20.120.370	http://www.cathdb.info/version/latest/superfamily/1.20.120.370
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	CHRNA10	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CHRNA10
GeneID	57053	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57053
GeneTree	ENSGT00790000122957	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00790000122957
HGNC	HGNC:13800	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13800
HOGENOM	HOG000006756	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006756&db=HOGENOM6
HOVERGEN	HBG003756	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003756&db=HOVERGEN
InParanoid	Q9GZZ6	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9GZZ6
InterPro	IPR002394	http://www.ebi.ac.uk/interpro/entry/IPR002394
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
InterPro	IPR027361	http://www.ebi.ac.uk/interpro/entry/IPR027361
Jabion	57053	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=57053
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:57053	http://www.genome.jp/dbget-bin/www_bget?hsa:57053
KEGG_Orthology	KO:K04811	http://www.genome.jp/dbget-bin/www_bget?KO:K04811
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
MIM	606372	http://www.ncbi.nlm.nih.gov/omim/606372
OMA	AQRCHED	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AQRCHED
OrthoDB	EOG091G0R20	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0R20
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00254	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00254
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:ACH10_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ACH10_HUMAN
PSORT-B	swissprot:ACH10_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ACH10_HUMAN
PSORT2	swissprot:ACH10_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ACH10_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA26488	http://www.pharmgkb.org/do/serve?objId=PA26488&objCls=Gene
Phobius	swissprot:ACH10_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ACH10_HUMAN
PhylomeDB	Q9GZZ6	http://phylomedb.org/?seqid=Q9GZZ6
ProteinModelPortal	Q9GZZ6	http://www.proteinmodelportal.org/query/uniprot/Q9GZZ6
PubMed	11350119	http://www.ncbi.nlm.nih.gov/pubmed/11350119
PubMed	11752216	http://www.ncbi.nlm.nih.gov/pubmed/11752216
PubMed	15531379	http://www.ncbi.nlm.nih.gov/pubmed/15531379
RefSeq	NP_001289963	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001289963
RefSeq	NP_001289964	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001289964
RefSeq	NP_065135	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_065135
STRING	9606.ENSP00000250699	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000250699&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc001lyf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001lyf&org=rat
UniGene	Hs.732806	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.732806
UniProtKB	ACH10_HUMAN	http://www.uniprot.org/uniprot/ACH10_HUMAN
UniProtKB-AC	Q9GZZ6	http://www.uniprot.org/uniprot/Q9GZZ6
charge	swissprot:ACH10_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ACH10_HUMAN
eggNOG	ENOG410XQGR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQGR
eggNOG	KOG3645	http://eggnogapi.embl.de/nog_data/html/tree/KOG3645
epestfind	swissprot:ACH10_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ACH10_HUMAN
garnier	swissprot:ACH10_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ACH10_HUMAN
helixturnhelix	swissprot:ACH10_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACH10_HUMAN
hmoment	swissprot:ACH10_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ACH10_HUMAN
iep	swissprot:ACH10_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ACH10_HUMAN
inforesidue	swissprot:ACH10_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ACH10_HUMAN
neXtProt	NX_Q9GZZ6	http://www.nextprot.org/db/entry/NX_Q9GZZ6
octanol	swissprot:ACH10_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ACH10_HUMAN
pepcoil	swissprot:ACH10_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ACH10_HUMAN
pepdigest	swissprot:ACH10_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ACH10_HUMAN
pepinfo	swissprot:ACH10_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ACH10_HUMAN
pepnet	swissprot:ACH10_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ACH10_HUMAN
pepstats	swissprot:ACH10_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ACH10_HUMAN
pepwheel	swissprot:ACH10_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ACH10_HUMAN
pepwindow	swissprot:ACH10_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ACH10_HUMAN
sigcleave	swissprot:ACH10_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ACH10_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S22A5_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O76082-1; Sequence=Displayed; Name=2; IsoId=O76082-2; Sequence=VSP_011120, VSP_011121; Note=No experimental confirmation available.; Name=3; Synonyms=OCTN2VT; IsoId=O76082-3; Sequence=VSP_043904; Note=Retained in the ER, unable to perform carnitine uptake.; 
# AltName	S22A5_HUMAN	High-affinity sodium-dependent carnitine cotransporter
# AltName	S22A5_HUMAN	Organic cation/carnitine transporter 2
# BioGrid	112471	5
# CCDS	CCDS4154	-. [O76082-1]
# CCDS	CCDS78058	-. [O76082-3]
# CDD	cd06174	MFS
# DISEASE	S22A5_HUMAN	Systemic primary carnitine deficiency (CDSP) [MIM 212140]  Autosomal recessive disorder of fatty acid oxidation caused by defective carnitine transport. Present early in life with hypoketotic hypoglycemia and acute metabolic decompensation, or later in life with skeletal myopathy or cardiomyopathy. {ECO 0000269|PubMed 10072434, ECO 0000269|PubMed 10425211, ECO 0000269|PubMed 10480371, ECO 0000269|PubMed 10545605, ECO 0000269|PubMed 10612840, ECO 0000269|PubMed 10679939, ECO 0000269|PubMed 11058897, ECO 0000269|PubMed 11715001, ECO 0000269|PubMed 15617188, ECO 0000269|PubMed 15714519, ECO 0000269|PubMed 17126586, ECO 0000269|PubMed 20027113, ECO 0000269|PubMed 20074989, ECO 0000269|PubMed 20574985, ECO 0000269|PubMed 21922592}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00122	Choline
# DrugBank	DB00125	L-Arginine
# DrugBank	DB00148	Creatine
# DrugBank	DB00152	Thiamine
# DrugBank	DB00182	Amphetamine
# DrugBank	DB00184	Nicotine
# DrugBank	DB00281	Lidocaine
# DrugBank	DB00313	Valproic Acid
# DrugBank	DB00332	Ipratropium bromide
# DrugBank	DB00345	Aminohippurate
# DrugBank	DB00368	Norepinephrine
# DrugBank	DB00415	Ampicillin
# DrugBank	DB00438	Ceftazidime
# DrugBank	DB00456	Cefalotin
# DrugBank	DB00468	Quinine
# DrugBank	DB00501	Cimetidine
# DrugBank	DB00535	Cefdinir
# DrugBank	DB00536	Guanidine
# DrugBank	DB00567	Cephalexin
# DrugBank	DB00575	Clonidine
# DrugBank	DB00583	L-Carnitine
# DrugBank	DB00627	Niacin
# DrugBank	DB00661	Verapamil
# DrugBank	DB00667	Histamine Phosphate
# DrugBank	DB00668	Epinephrine
# DrugBank	DB00671	Cefixime
# DrugBank	DB00689	Cephaloglycin
# DrugBank	DB00695	Furosemide
# DrugBank	DB00908	Quinidine
# DrugBank	DB00970	Dactinomycin
# DrugBank	DB00978	Lomefloxacin
# DrugBank	DB00988	Dopamine
# DrugBank	DB01000	Cyclacillin
# DrugBank	DB01032	Probenecid
# DrugBank	DB01035	Procainamide
# DrugBank	DB01053	Benzylpenicillin
# DrugBank	DB01059	Norfloxacin
# DrugBank	DB01075	Diphenhydramine
# DrugBank	DB01140	Cefadroxil
# DrugBank	DB01151	Desipramine
# DrugBank	DB01165	Ofloxacin
# DrugBank	DB01208	Sparfloxacin
# DrugBank	DB01333	Cefradine
# DrugBank	DB01409	Tiotropium
# DrugBank	DB01413	Cefepime
# DrugBank	DB01577	Methamphetamine
# DrugBank	DB03128	Acetylcholine
# DrugBank	DB06691	Mepyramine
# DrugBank	DB08795	Azidocillin
# DrugBank	DB08842	Acetylcarnitine
# Ensembl	ENST00000245407	ENSP00000245407; ENSG00000197375. [O76082-1]
# Ensembl	ENST00000435065	ENSP00000402760; ENSG00000197375. [O76082-3]
# ExpressionAtlas	O76082	baseline and differential
# FUNCTION	S22A5_HUMAN	Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3. {ECO 0000269|PubMed 10454528}. 
# GO_component	GO:0005886	plasma membrane; IC:BHF-UCL.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016324	apical plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0031526	brush border membrane; IDA:BHF-UCL.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0015226	carnitine transmembrane transporter activity; IDA:BHF-UCL.
# GO_function	GO:0015238	drug transmembrane transporter activity; IC:BHF-UCL.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_function	GO:0015651	quaternary ammonium group transmembrane transporter activity; IDA:BHF-UCL.
# GO_function	GO:0030165	PDZ domain binding; IPI:BHF-UCL.
# GO_function	S22A5_HUMAN	GO 0015491 cation cation antiporter activity; IBA GO_Central.
# GO_process	GO:0006814	sodium ion transport; IEA:UniProtKB-KW.
# GO_process	GO:0009437	carnitine metabolic process; IBA:GO_Central.
# GO_process	GO:0015697	quaternary ammonium group transport; IDA:BHF-UCL.
# GO_process	GO:0015879	carnitine transport; IDA:BHF-UCL.
# GO_process	GO:0015893	drug transport; IC:BHF-UCL.
# GO_process	GO:0052106	quorum sensing involved in interaction with host; IMP:BHF-UCL.
# GO_process	GO:0060731	positive regulation of intestinal epithelial structure maintenance; IMP:BHF-UCL.
# GO_process	GO:0070715	sodium-dependent organic cation transport; IDA:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0042592	homeostatic process
# Genevisible	O76082	HS
# HGNC	HGNC:10969	SLC22A5
# IntAct	O76082	5
# InterPro	IPR004749	Orgcat_transp/SVOP
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR005829	Sugar_transporter_CS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H00286	[Immune system disease] Crohn's disease
# KEGG_Disease	H00525	[Inherited metabolic disease] Systemic primary carnitine deficiency (CDSP)
# KEGG_Disease	H01589	[Inherited metabolic disease] Systemic primary carnitine deficiency
# MIM	212140	phenotype
# MIM	603377	gene
# MISCELLANEOUS	S22A5_HUMAN	Inhibited by emetine, quinidine and verapamil. The IC(50) of emetine is 4.2 uM. Not inhibited by valproic acid. 
# Organism	S22A5_HUMAN	Homo sapiens (Human)
# Orphanet	158	Systemic primary carnitine deficiency
# PIR	JW0089	JW0089
# PROSITE	PS00216	SUGAR_TRANSPORT_1
# PROSITE	PS50850	MFS
# Pfam	PF00083	Sugar_tr
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-549127	Organic cation transport
# RecName	S22A5_HUMAN	Solute carrier family 22 member 5
# RefSeq	NP_001295051	NM_001308122.1. [O76082-3]
# RefSeq	NP_003051	NM_003060.3. [O76082-1]
# SIMILARITY	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S22A5_HUMAN	Membrane {ECO 0000269|PubMed 10679939}; Multi-pass membrane protein {ECO 0000269|PubMed 10679939}. 
# SUBUNIT	Interacts with PDZK1. {ECO	0000250}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.19	the major facilitator superfamily (mfs)
# TIGRFAMs	TIGR00898	2A0119
# TISSUE SPECIFICITY	Strongly expressed in kidney, skeletal muscle, heart and placenta. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells. {ECO:0000269|PubMed	10454528}. 
# UCSC	uc003kww	human. [O76082-1]
# WEB RESOURCE	S22A5_HUMAN	Name=The SLC22A5 database; URL="http //www.arup.utah.edu/database/OCTN2/OCTN2_welcome.php";
# eggNOG	ENOG410IRIE	Eukaryota
# eggNOG	ENOG410XSRI	LUCA
BLAST	swissprot:S22A5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S22A5_HUMAN
BioCyc	ZFISH:G66-31071-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31071-MONOMER
COXPRESdb	6584	http://coxpresdb.jp/data/gene/6584.shtml
CleanEx	HS_SLC22A5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC22A5
DOI	10.1002/(SICI)1098-1004(200001)15:1<118::AID-HUMU28>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(200001)15:1<118::AID-HUMU28>3.0.CO
DOI	10.1002/(SICI)1098-1004(200003)15:3<238::AID-HUMU4>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(200003)15:3<238::AID-HUMU4>3.0.CO
DOI	10.1002/1098-1004(200011)16:5<401::AID-HUMU4>3.0.CO	http://dx.doi.org/10.1002/1098-1004(200011)16:5<401::AID-HUMU4>3.0.CO
DOI	10.1002/humu.20137	http://dx.doi.org/10.1002/humu.20137
DOI	10.1002/humu.21311	http://dx.doi.org/10.1002/humu.21311
DOI	10.1002/humu.21607	http://dx.doi.org/10.1002/humu.21607
DOI	10.1006/bbrc.1998.8669	http://dx.doi.org/10.1006/bbrc.1998.8669
DOI	10.1006/bbrc.1999.1060	http://dx.doi.org/10.1006/bbrc.1999.1060
DOI	10.1007/s004399900105	http://dx.doi.org/10.1007/s004399900105
DOI	10.1016/j.bbamcr.2007.04.005	http://dx.doi.org/10.1016/j.bbamcr.2007.04.005
DOI	10.1016/j.ymgme.2006.10.003	http://dx.doi.org/10.1016/j.ymgme.2006.10.003
DOI	10.1016/j.ymgme.2009.12.015	http://dx.doi.org/10.1016/j.ymgme.2009.12.015
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1023/B:BOLI.0000045837.23328.f4	http://dx.doi.org/10.1023/B:BOLI.0000045837.23328.f4
DOI	10.1038/5030	http://dx.doi.org/10.1038/5030
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1038/nbt.1532	http://dx.doi.org/10.1038/nbt.1532
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.273.32.20378	http://dx.doi.org/10.1074/jbc.273.32.20378
DOI	10.1074/jbc.274.47.33388	http://dx.doi.org/10.1074/jbc.274.47.33388
DOI	10.1093/hmg/8.12.2247	http://dx.doi.org/10.1093/hmg/8.12.2247
DOI	10.1093/hmg/8.4.655	http://dx.doi.org/10.1093/hmg/8.4.655
DOI	10.1097/00125817-200111000-00002	http://dx.doi.org/10.1097/00125817-200111000-00002
DOI	10.1097/GIM.0b013e3181c5e6f7	http://dx.doi.org/10.1097/GIM.0b013e3181c5e6f7
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1124/mol.106.028126	http://dx.doi.org/10.1124/mol.106.028126
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DrugBank	DB00122	http://www.drugbank.ca/drugs/DB00122
DrugBank	DB00125	http://www.drugbank.ca/drugs/DB00125
DrugBank	DB00148	http://www.drugbank.ca/drugs/DB00148
DrugBank	DB00152	http://www.drugbank.ca/drugs/DB00152
DrugBank	DB00182	http://www.drugbank.ca/drugs/DB00182
DrugBank	DB00184	http://www.drugbank.ca/drugs/DB00184
DrugBank	DB00281	http://www.drugbank.ca/drugs/DB00281
DrugBank	DB00313	http://www.drugbank.ca/drugs/DB00313
DrugBank	DB00332	http://www.drugbank.ca/drugs/DB00332
DrugBank	DB00345	http://www.drugbank.ca/drugs/DB00345
DrugBank	DB00368	http://www.drugbank.ca/drugs/DB00368
DrugBank	DB00415	http://www.drugbank.ca/drugs/DB00415
DrugBank	DB00438	http://www.drugbank.ca/drugs/DB00438
DrugBank	DB00456	http://www.drugbank.ca/drugs/DB00456
DrugBank	DB00468	http://www.drugbank.ca/drugs/DB00468
DrugBank	DB00501	http://www.drugbank.ca/drugs/DB00501
DrugBank	DB00535	http://www.drugbank.ca/drugs/DB00535
DrugBank	DB00536	http://www.drugbank.ca/drugs/DB00536
DrugBank	DB00567	http://www.drugbank.ca/drugs/DB00567
DrugBank	DB00575	http://www.drugbank.ca/drugs/DB00575
DrugBank	DB00583	http://www.drugbank.ca/drugs/DB00583
DrugBank	DB00627	http://www.drugbank.ca/drugs/DB00627
DrugBank	DB00661	http://www.drugbank.ca/drugs/DB00661
DrugBank	DB00667	http://www.drugbank.ca/drugs/DB00667
DrugBank	DB00668	http://www.drugbank.ca/drugs/DB00668
DrugBank	DB00671	http://www.drugbank.ca/drugs/DB00671
DrugBank	DB00689	http://www.drugbank.ca/drugs/DB00689
DrugBank	DB00695	http://www.drugbank.ca/drugs/DB00695
DrugBank	DB00908	http://www.drugbank.ca/drugs/DB00908
DrugBank	DB00970	http://www.drugbank.ca/drugs/DB00970
DrugBank	DB00978	http://www.drugbank.ca/drugs/DB00978
DrugBank	DB00988	http://www.drugbank.ca/drugs/DB00988
DrugBank	DB01000	http://www.drugbank.ca/drugs/DB01000
DrugBank	DB01032	http://www.drugbank.ca/drugs/DB01032
DrugBank	DB01035	http://www.drugbank.ca/drugs/DB01035
DrugBank	DB01053	http://www.drugbank.ca/drugs/DB01053
DrugBank	DB01059	http://www.drugbank.ca/drugs/DB01059
DrugBank	DB01075	http://www.drugbank.ca/drugs/DB01075
DrugBank	DB01140	http://www.drugbank.ca/drugs/DB01140
DrugBank	DB01151	http://www.drugbank.ca/drugs/DB01151
DrugBank	DB01165	http://www.drugbank.ca/drugs/DB01165
DrugBank	DB01208	http://www.drugbank.ca/drugs/DB01208
DrugBank	DB01333	http://www.drugbank.ca/drugs/DB01333
DrugBank	DB01409	http://www.drugbank.ca/drugs/DB01409
DrugBank	DB01413	http://www.drugbank.ca/drugs/DB01413
DrugBank	DB01577	http://www.drugbank.ca/drugs/DB01577
DrugBank	DB03128	http://www.drugbank.ca/drugs/DB03128
DrugBank	DB06691	http://www.drugbank.ca/drugs/DB06691
DrugBank	DB08795	http://www.drugbank.ca/drugs/DB08795
DrugBank	DB08842	http://www.drugbank.ca/drugs/DB08842
EMBL	AB015050	http://www.ebi.ac.uk/ena/data/view/AB015050
EMBL	AB016625	http://www.ebi.ac.uk/ena/data/view/AB016625
EMBL	AB291606	http://www.ebi.ac.uk/ena/data/view/AB291606
EMBL	AC118464	http://www.ebi.ac.uk/ena/data/view/AC118464
EMBL	AF057164	http://www.ebi.ac.uk/ena/data/view/AF057164
EMBL	AK128610	http://www.ebi.ac.uk/ena/data/view/AK128610
EMBL	AK313230	http://www.ebi.ac.uk/ena/data/view/AK313230
EMBL	BC012325	http://www.ebi.ac.uk/ena/data/view/BC012325
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
Ensembl	ENST00000245407	http://www.ensembl.org/id/ENST00000245407
Ensembl	ENST00000435065	http://www.ensembl.org/id/ENST00000435065
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0031526	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031526
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0015226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015226
GO_function	GO:0015238	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015238
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_function	GO:0015491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015491
GO_function	GO:0015651	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015651
GO_function	GO:0030165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030165
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0009437	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009437
GO_process	GO:0015697	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015697
GO_process	GO:0015879	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015879
GO_process	GO:0015893	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015893
GO_process	GO:0052106	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052106
GO_process	GO:0060731	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060731
GO_process	GO:0070715	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070715
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GeneCards	SLC22A5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC22A5
GeneID	6584	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6584
GeneTree	ENSGT00760000118852	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118852
HGNC	HGNC:10969	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10969
HOGENOM	HOG000234570	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234570&db=HOGENOM6
HOVERGEN	HBG061545	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG061545&db=HOVERGEN
HPA	HPA066969	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA066969
InParanoid	O76082	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O76082
IntAct	O76082	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O76082*
InterPro	IPR004749	http://www.ebi.ac.uk/interpro/entry/IPR004749
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR005829	http://www.ebi.ac.uk/interpro/entry/IPR005829
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	6584	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6584
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00286	http://www.genome.jp/dbget-bin/www_bget?H00286
KEGG_Disease	H00525	http://www.genome.jp/dbget-bin/www_bget?H00525
KEGG_Disease	H01589	http://www.genome.jp/dbget-bin/www_bget?H01589
KEGG_Gene	hsa:6584	http://www.genome.jp/dbget-bin/www_bget?hsa:6584
KEGG_Orthology	KO:K08202	http://www.genome.jp/dbget-bin/www_bget?KO:K08202
MIM	212140	http://www.ncbi.nlm.nih.gov/omim/212140
MIM	603377	http://www.ncbi.nlm.nih.gov/omim/603377
OMA	TRNIRMI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TRNIRMI
Orphanet	158	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=158
OrthoDB	EOG091G05AC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05AC
PROSITE	PS00216	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00216
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:S22A5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S22A5_HUMAN
PSORT-B	swissprot:S22A5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S22A5_HUMAN
PSORT2	swissprot:S22A5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S22A5_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
PharmGKB	PA333	http://www.pharmgkb.org/do/serve?objId=PA333&objCls=Gene
Phobius	swissprot:S22A5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S22A5_HUMAN
PhylomeDB	O76082	http://phylomedb.org/?seqid=O76082
ProteinModelPortal	O76082	http://www.proteinmodelportal.org/query/uniprot/O76082
PubMed	10072434	http://www.ncbi.nlm.nih.gov/pubmed/10072434
PubMed	10425211	http://www.ncbi.nlm.nih.gov/pubmed/10425211
PubMed	10454528	http://www.ncbi.nlm.nih.gov/pubmed/10454528
PubMed	10480371	http://www.ncbi.nlm.nih.gov/pubmed/10480371
PubMed	10545605	http://www.ncbi.nlm.nih.gov/pubmed/10545605
PubMed	10559218	http://www.ncbi.nlm.nih.gov/pubmed/10559218
PubMed	10612840	http://www.ncbi.nlm.nih.gov/pubmed/10612840
PubMed	10679939	http://www.ncbi.nlm.nih.gov/pubmed/10679939
PubMed	11058897	http://www.ncbi.nlm.nih.gov/pubmed/11058897
PubMed	11715001	http://www.ncbi.nlm.nih.gov/pubmed/11715001
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15617188	http://www.ncbi.nlm.nih.gov/pubmed/15617188
PubMed	15714519	http://www.ncbi.nlm.nih.gov/pubmed/15714519
PubMed	16931768	http://www.ncbi.nlm.nih.gov/pubmed/16931768
PubMed	17126586	http://www.ncbi.nlm.nih.gov/pubmed/17126586
PubMed	17509700	http://www.ncbi.nlm.nih.gov/pubmed/17509700
PubMed	19349973	http://www.ncbi.nlm.nih.gov/pubmed/19349973
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20027113	http://www.ncbi.nlm.nih.gov/pubmed/20027113
PubMed	20074989	http://www.ncbi.nlm.nih.gov/pubmed/20074989
PubMed	20574985	http://www.ncbi.nlm.nih.gov/pubmed/20574985
PubMed	21922592	http://www.ncbi.nlm.nih.gov/pubmed/21922592
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	9618255	http://www.ncbi.nlm.nih.gov/pubmed/9618255
PubMed	9685390	http://www.ncbi.nlm.nih.gov/pubmed/9685390
PubMed	9916797	http://www.ncbi.nlm.nih.gov/pubmed/9916797
Reactome	R-HSA-549127	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-549127
RefSeq	NP_001295051	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001295051
RefSeq	NP_003051	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003051
STRING	9606.ENSP00000245407	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000245407&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.19	http://www.tcdb.org/search/result.php?tc=2.A.1.19
TIGRFAMs	TIGR00898	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00898
UCSC	uc003kww	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003kww&org=rat
UniGene	Hs.443572	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.443572
UniProtKB	S22A5_HUMAN	http://www.uniprot.org/uniprot/S22A5_HUMAN
UniProtKB-AC	O76082	http://www.uniprot.org/uniprot/O76082
charge	swissprot:S22A5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S22A5_HUMAN
eggNOG	ENOG410IRIE	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IRIE
eggNOG	ENOG410XSRI	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSRI
epestfind	swissprot:S22A5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S22A5_HUMAN
garnier	swissprot:S22A5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S22A5_HUMAN
helixturnhelix	swissprot:S22A5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S22A5_HUMAN
hmoment	swissprot:S22A5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S22A5_HUMAN
iep	swissprot:S22A5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S22A5_HUMAN
inforesidue	swissprot:S22A5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S22A5_HUMAN
neXtProt	NX_O76082	http://www.nextprot.org/db/entry/NX_O76082
octanol	swissprot:S22A5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S22A5_HUMAN
pepcoil	swissprot:S22A5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S22A5_HUMAN
pepdigest	swissprot:S22A5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S22A5_HUMAN
pepinfo	swissprot:S22A5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S22A5_HUMAN
pepnet	swissprot:S22A5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S22A5_HUMAN
pepstats	swissprot:S22A5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S22A5_HUMAN
pepwheel	swissprot:S22A5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S22A5_HUMAN
pepwindow	swissprot:S22A5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S22A5_HUMAN
sigcleave	swissprot:S22A5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S22A5_HUMAN
## Database	ID	URL or Descriptions
# AltName	CRFM7_HUMAN	CHRNA7-DR1
# AltName	CRFM7_HUMAN	D-10
# CAUTION	This protein is encoded by a hybrid gene consisting of a duplication of exons 5 through 10 of the CHRNA7 gene fused 3-prime to a copy of the FAM7A gene (exons A through E). The CHRFAM7A gene is in the opposite orientation to the CHRNA7 gene. It seems not to be represented on every human chromosome 15 and it is not clear whether the transcript is actually translated. {ECO	0000305}.
# ChiTaRS	CHRFAM7A	human
# Ensembl	ENST00000299847	ENSP00000299847; ENSG00000166664
# ExpressionAtlas	Q494W8	baseline and differential
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005230	extracellular ligand-gated ion channel activity; IEA:InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# Gene3D	1.20.120.370	-; 2.
# Gene3D	2.70.170.10	-; 1.
# Genevisible	Q494W8	HS
# HGNC	HGNC:15781	CHRFAM7A
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# InterPro	IPR027361	Acetylcholine_rcpt_TM
# MIM	609756	gene
# Organism	CRFM7_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR18945	PTHR18945; 3
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 15
# RecName	CRFM7_HUMAN	CHRNA7-FAM7A fusion protein
# RefSeq	NP_647536	NM_139320.1
# RefSeq	XP_011520455	XM_011522153.1
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	CRFM7_HUMAN	Membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TIGRFAMs	TIGR00860	LIC
# TISSUE SPECIFICITY	Expressed in hippocampus. {ECO:0000269|PubMed	9782083}. 
# UCSC	uc001zdt	human
# eggNOG	ENOG410XQGR	LUCA
# eggNOG	KOG3645	Eukaryota
BLAST	swissprot:CRFM7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CRFM7_HUMAN
COXPRESdb	89832	http://coxpresdb.jp/data/gene/89832.shtml
CleanEx	HS_CHRFAM7A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CHRFAM7A
DOI	10.1006/geno.1998.5363	http://dx.doi.org/10.1006/geno.1998.5363
DOI	10.1038/nature04601	http://dx.doi.org/10.1038/nature04601
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC010799	http://www.ebi.ac.uk/ena/data/view/AC010799
EMBL	AC019322	http://www.ebi.ac.uk/ena/data/view/AC019322
EMBL	AF029838	http://www.ebi.ac.uk/ena/data/view/AF029838
EMBL	AK292984	http://www.ebi.ac.uk/ena/data/view/AK292984
EMBL	BC101346	http://www.ebi.ac.uk/ena/data/view/BC101346
EMBL	BC101347	http://www.ebi.ac.uk/ena/data/view/BC101347
EMBL	BC101348	http://www.ebi.ac.uk/ena/data/view/BC101348
Ensembl	ENST00000299847	http://www.ensembl.org/id/ENST00000299847
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005230	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005230
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
Gene3D	1.20.120.370	http://www.cathdb.info/version/latest/superfamily/1.20.120.370
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	CHRFAM7A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CHRFAM7A
GeneID	89832	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=89832
GeneTree	ENSGT00790000122957	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00790000122957
H-InvDB	HIX0038397	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0038397
HGNC	HGNC:15781	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:15781
HOGENOM	HOG000006756	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006756&db=HOGENOM6
HOVERGEN	HBG003756	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003756&db=HOVERGEN
InParanoid	Q494W8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q494W8
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
InterPro	IPR027361	http://www.ebi.ac.uk/interpro/entry/IPR027361
Jabion	89832	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=89832
KEGG_Gene	hsa:89832	http://www.genome.jp/dbget-bin/www_bget?hsa:89832
MIM	609756	http://www.ncbi.nlm.nih.gov/omim/609756
OMA	STGYCQY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=STGYCQY
OrthoDB	EOG091G0R20	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0R20
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:CRFM7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CRFM7_HUMAN
PSORT-B	swissprot:CRFM7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CRFM7_HUMAN
PSORT2	swissprot:CRFM7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CRFM7_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA26483	http://www.pharmgkb.org/do/serve?objId=PA26483&objCls=Gene
Phobius	swissprot:CRFM7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CRFM7_HUMAN
PhylomeDB	Q494W8	http://phylomedb.org/?seqid=Q494W8
ProteinModelPortal	Q494W8	http://www.proteinmodelportal.org/query/uniprot/Q494W8
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16572171	http://www.ncbi.nlm.nih.gov/pubmed/16572171
PubMed	9782083	http://www.ncbi.nlm.nih.gov/pubmed/9782083
RefSeq	NP_647536	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_647536
RefSeq	XP_011520455	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011520455
STRING	9606.ENSP00000299847	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000299847&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc001zdt	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001zdt&org=rat
UniGene	Hs.510853	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.510853
UniProtKB	CRFM7_HUMAN	http://www.uniprot.org/uniprot/CRFM7_HUMAN
UniProtKB-AC	Q494W8	http://www.uniprot.org/uniprot/Q494W8
charge	swissprot:CRFM7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CRFM7_HUMAN
eggNOG	ENOG410XQGR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQGR
eggNOG	KOG3645	http://eggnogapi.embl.de/nog_data/html/tree/KOG3645
epestfind	swissprot:CRFM7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CRFM7_HUMAN
garnier	swissprot:CRFM7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CRFM7_HUMAN
helixturnhelix	swissprot:CRFM7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CRFM7_HUMAN
hmoment	swissprot:CRFM7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CRFM7_HUMAN
iep	swissprot:CRFM7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CRFM7_HUMAN
inforesidue	swissprot:CRFM7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CRFM7_HUMAN
neXtProt	NX_Q494W8	http://www.nextprot.org/db/entry/NX_Q494W8
octanol	swissprot:CRFM7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CRFM7_HUMAN
pepcoil	swissprot:CRFM7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CRFM7_HUMAN
pepdigest	swissprot:CRFM7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CRFM7_HUMAN
pepinfo	swissprot:CRFM7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CRFM7_HUMAN
pepnet	swissprot:CRFM7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CRFM7_HUMAN
pepstats	swissprot:CRFM7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CRFM7_HUMAN
pepwheel	swissprot:CRFM7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CRFM7_HUMAN
pepwindow	swissprot:CRFM7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CRFM7_HUMAN
sigcleave	swissprot:CRFM7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CRFM7_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	NIPA4_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q0D2K0-1; Sequence=Displayed; Name=2; IsoId=Q0D2K0-2; Sequence=VSP_036122; 
# AltName	NIPA4_HUMAN	Ichthyin
# AltName	NIPA4_HUMAN	NIPA-like protein 4
# AltName	NIPA4_HUMAN	Non-imprinted in Prader-Willi/Angelman syndrome region protein 4
# CCDS	CCDS47328	-. [Q0D2K0-1]
# CCDS	CCDS54944	-. [Q0D2K0-2]
# DISEASE	NIPA4_HUMAN	Ichthyosis, congenital, autosomal recessive 6 (ARCI6) [MIM 612281]  A form of autosomal recessive congenital ichthyosis, a disorder of keratinization with abnormal differentiation and desquamation of the epidermis, resulting in abnormal skin scaling over the whole body. The main skin phenotypes are lamellar ichthyosis (LI) and non-bullous congenital ichthyosiform erythroderma (NCIE), although phenotypic overlap within the same patient or among patients from the same family can occur. Lamellar ichthyosis is a condition often associated with an embedment in a collodion-like membrane at birth; skin scales later develop, covering the entire body surface. Non-bullous congenital ichthyosiform erythroderma characterized by fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs. {ECO 0000269|PubMed 15317751, ECO 0000269|PubMed 17557927, ECO 0000269|PubMed 26456858}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000311946	ENSP00000311687; ENSG00000172548. [Q0D2K0-1]
# Ensembl	ENST00000435489	ENSP00000406456; ENSG00000172548. [Q0D2K0-2]
# ExpressionAtlas	Q0D2K0	baseline and differential
# FUNCTION	NIPA4_HUMAN	Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway. {ECO 0000250, ECO 0000269|PubMed 15317751}. 
# GO_component	GO:0005654	nucleoplasm; IDA:HPA.
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0016020	membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015095	magnesium ion transmembrane transporter activity; IEA:InterPro.
# GO_process	GO:0015693	magnesium ion transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005737	cytoplasm
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q0D2K0	HS
# HGNC	HGNC:28018	NIPAL4
# IntAct	Q0D2K0	2
# InterPro	IPR008521	Mg_trans_NIPA
# KEGG_Disease	H00734	[Congenital disorder; Skin and connective tissue disease] Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
# MIM	609383	gene
# MIM	612281	phenotype
# Organism	NIPA4_HUMAN	Homo sapiens (Human)
# Orphanet	313	Lamellar ichthyosis
# Orphanet	79394	Congenital non-bullous ichthyosiform erythroderma
# PANTHER	PTHR12570	PTHR12570
# Pfam	PF05653	Mg_trans_NIPA
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-5223345	Miscellaneous transport and binding events
# RecName	NIPA4_HUMAN	Magnesium transporter NIPA4
# RefSeq	NP_001092757	NM_001099287.1. [Q0D2K0-1]
# RefSeq	NP_001165763	NM_001172292.1. [Q0D2K0-2]
# SEQUENCE CAUTION	Sequence=ABW69630.1; Type=Miscellaneous discrepancy; Note=Protein truncation is due to an exon 5 splice site mutation which is found in a ARCII patient.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the NIPA family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	NIPA4_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	2.A.7.25	the drug/metabolite transporter (dmt) superfamily
# TISSUE SPECIFICITY	NIPA4_HUMAN	Highly expressed in brain, lung, stomach, keratinocytes and leukocytes, and in all other tissues tested except liver, thyroid and fetal brain. {ECO 0000269|PubMed 15317751, ECO 0000269|PubMed 17557927}. 
# UCSC	uc003lwx	human. [Q0D2K0-1]
# eggNOG	ENOG410XNR8	LUCA
# eggNOG	KOG2922	Eukaryota
BLAST	swissprot:NIPA4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NIPA4_HUMAN
COXPRESdb	348938	http://coxpresdb.jp/data/gene/348938.shtml
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/hmg/ddh263	http://dx.doi.org/10.1093/hmg/ddh263
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/ced.12740	http://dx.doi.org/10.1111/ced.12740
DOI	10.1136/jmg.2007.050542	http://dx.doi.org/10.1136/jmg.2007.050542
EMBL	AC008676	http://www.ebi.ac.uk/ena/data/view/AC008676
EMBL	AK296972	http://www.ebi.ac.uk/ena/data/view/AK296972
EMBL	BC105708	http://www.ebi.ac.uk/ena/data/view/BC105708
EMBL	BC105709	http://www.ebi.ac.uk/ena/data/view/BC105709
EMBL	BC105710	http://www.ebi.ac.uk/ena/data/view/BC105710
EMBL	EF599763	http://www.ebi.ac.uk/ena/data/view/EF599763
EMBL	EF599764	http://www.ebi.ac.uk/ena/data/view/EF599764
EMBL	EF599765	http://www.ebi.ac.uk/ena/data/view/EF599765
EMBL	EF599766	http://www.ebi.ac.uk/ena/data/view/EF599766
Ensembl	ENST00000311946	http://www.ensembl.org/id/ENST00000311946
Ensembl	ENST00000435489	http://www.ensembl.org/id/ENST00000435489
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015095
GO_process	GO:0015693	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015693
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	NIPAL4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=NIPAL4
GeneID	348938	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=348938
GeneTree	ENSGT00550000074395	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074395
H-InvDB	HIX0005358	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0005358
HGNC	HGNC:28018	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:28018
HPA	HPA038258	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA038258
HPA	HPA038259	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA038259
InParanoid	Q0D2K0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q0D2K0
IntAct	Q0D2K0	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q0D2K0*
InterPro	IPR008521	http://www.ebi.ac.uk/interpro/entry/IPR008521
Jabion	348938	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=348938
KEGG_Disease	H00734	http://www.genome.jp/dbget-bin/www_bget?H00734
KEGG_Gene	hsa:348938	http://www.genome.jp/dbget-bin/www_bget?hsa:348938
MIM	609383	http://www.ncbi.nlm.nih.gov/omim/609383
MIM	612281	http://www.ncbi.nlm.nih.gov/omim/612281
OMA	FHSWQER	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FHSWQER
Orphanet	313	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=313
Orphanet	79394	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=79394
OrthoDB	EOG091G0M8A	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0M8A
PANTHER	PTHR12570	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12570
PSORT	swissprot:NIPA4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NIPA4_HUMAN
PSORT-B	swissprot:NIPA4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NIPA4_HUMAN
PSORT2	swissprot:NIPA4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NIPA4_HUMAN
Pfam	PF05653	http://pfam.xfam.org/family/PF05653
PharmGKB	PA164723956	http://www.pharmgkb.org/do/serve?objId=PA164723956&objCls=Gene
Phobius	swissprot:NIPA4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NIPA4_HUMAN
PhylomeDB	Q0D2K0	http://phylomedb.org/?seqid=Q0D2K0
ProteinModelPortal	Q0D2K0	http://www.proteinmodelportal.org/query/uniprot/Q0D2K0
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15317751	http://www.ncbi.nlm.nih.gov/pubmed/15317751
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17557927	http://www.ncbi.nlm.nih.gov/pubmed/17557927
PubMed	26456858	http://www.ncbi.nlm.nih.gov/pubmed/26456858
Reactome	R-HSA-5223345	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5223345
RefSeq	NP_001092757	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001092757
RefSeq	NP_001165763	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001165763
STRING	9606.ENSP00000311687	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000311687&targetmode=cogs
TCDB	2.A.7.25	http://www.tcdb.org/search/result.php?tc=2.A.7.25
UCSC	uc003lwx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003lwx&org=rat
UniGene	Hs.4285	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.4285
UniProtKB	NIPA4_HUMAN	http://www.uniprot.org/uniprot/NIPA4_HUMAN
UniProtKB-AC	Q0D2K0	http://www.uniprot.org/uniprot/Q0D2K0
charge	swissprot:NIPA4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NIPA4_HUMAN
eggNOG	ENOG410XNR8	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNR8
eggNOG	KOG2922	http://eggnogapi.embl.de/nog_data/html/tree/KOG2922
epestfind	swissprot:NIPA4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NIPA4_HUMAN
garnier	swissprot:NIPA4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NIPA4_HUMAN
helixturnhelix	swissprot:NIPA4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NIPA4_HUMAN
hmoment	swissprot:NIPA4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NIPA4_HUMAN
iep	swissprot:NIPA4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NIPA4_HUMAN
inforesidue	swissprot:NIPA4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NIPA4_HUMAN
neXtProt	NX_Q0D2K0	http://www.nextprot.org/db/entry/NX_Q0D2K0
octanol	swissprot:NIPA4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NIPA4_HUMAN
pepcoil	swissprot:NIPA4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NIPA4_HUMAN
pepdigest	swissprot:NIPA4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NIPA4_HUMAN
pepinfo	swissprot:NIPA4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NIPA4_HUMAN
pepnet	swissprot:NIPA4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NIPA4_HUMAN
pepstats	swissprot:NIPA4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NIPA4_HUMAN
pepwheel	swissprot:NIPA4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NIPA4_HUMAN
pepwindow	swissprot:NIPA4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NIPA4_HUMAN
sigcleave	swissprot:NIPA4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NIPA4_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	107005	42
# ChiTaRS	ATP5I	human
# Ensembl	ENST00000304312	ENSP00000306003; ENSG00000169020
# FUNCTION	ATP5I_HUMAN	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. 
# GO_component	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); IEA:Ensembl.
# GO_component	GO:0005739	mitochondrion; IDA:HPA.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0005753	mitochondrial proton-transporting ATP synthase complex; IDA:UniProtKB.
# GO_function	GO:0015078	hydrogen ion transmembrane transporter activity; IEA:InterPro.
# GO_function	GO:0022857	transmembrane transporter activity; IC:UniProtKB.
# GO_process	GO:0006754	ATP biosynthetic process; TAS:Reactome.
# GO_process	GO:0042776	mitochondrial ATP synthesis coupled proton transport; IC:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P56385	HS
# HGNC	HGNC:846	ATP5I
# IntAct	P56385	24
# InterPro	IPR008386	ATP_synth_F0_esu_mt
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# MIM	601519	gene
# Organism	ATP5I_HUMAN	Homo sapiens (Human)
# Pfam	PF05680	ATP-synt_E
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-163210	Formation of ATP by chemiosmotic coupling
# RecName	ATP5I_HUMAN	ATP synthase subunit e, mitochondrial
# RecName	ATP5I_HUMAN	ATP synthase subunit e, mitochondrial, N-terminally processed
# RefSeq	NP_009031	NM_007100.3
# SIMILARITY	Belongs to the ATPase e subunit family. {ECO	0000305}.
# SUBCELLULAR LOCATION	ATP5I_HUMAN	Mitochondrion. Mitochondrion inner membrane. 
# SUBUNIT	F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity). {ECO	0000250}. 
# UCSC	uc003gas	human
# eggNOG	ENOG410XYSS	LUCA
# eggNOG	KOG4326	Eukaryota
BLAST	swissprot:ATP5I_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ATP5I_HUMAN
BioCyc	ZFISH:HS09866-MONOMER	http://biocyc.org/getid?id=ZFISH:HS09866-MONOMER
COXPRESdb	521	http://coxpresdb.jp/data/gene/521.shtml
CleanEx	HS_ATP5I	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP5I
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1073/pnas.0908958106	http://dx.doi.org/10.1073/pnas.0908958106
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	BC003679	http://www.ebi.ac.uk/ena/data/view/BC003679
EMBL	BC105610	http://www.ebi.ac.uk/ena/data/view/BC105610
EMBL	BT006922	http://www.ebi.ac.uk/ena/data/view/BT006922
EMBL	D50371	http://www.ebi.ac.uk/ena/data/view/D50371
Ensembl	ENST00000304312	http://www.ensembl.org/id/ENST00000304312
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000276
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005753	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005753
GO_function	GO:0015078	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015078
GO_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GO_process	GO:0006754	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006754
GO_process	GO:0042776	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042776
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ATP5I	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP5I
GeneID	521	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=521
GeneTree	ENSGT00390000005102	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000005102
HGNC	HGNC:846	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:846
HOGENOM	HOG000231826	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231826&db=HOGENOM6
HOVERGEN	HBG050613	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050613&db=HOVERGEN
HPA	HPA035010	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035010
InParanoid	P56385	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P56385
IntAct	P56385	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P56385*
InterPro	IPR008386	http://www.ebi.ac.uk/interpro/entry/IPR008386
Jabion	521	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=521
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:521	http://www.genome.jp/dbget-bin/www_bget?hsa:521
KEGG_Orthology	KO:K02129	http://www.genome.jp/dbget-bin/www_bget?KO:K02129
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
MIM	601519	http://www.ncbi.nlm.nih.gov/omim/601519
OMA	EQERIYK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EQERIYK
OrthoDB	EOG091G13NK	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G13NK
PSORT	swissprot:ATP5I_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ATP5I_HUMAN
PSORT-B	swissprot:ATP5I_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ATP5I_HUMAN
PSORT2	swissprot:ATP5I_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ATP5I_HUMAN
Pfam	PF05680	http://pfam.xfam.org/family/PF05680
PharmGKB	PA25136	http://www.pharmgkb.org/do/serve?objId=PA25136&objCls=Gene
Phobius	swissprot:ATP5I_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ATP5I_HUMAN
PhylomeDB	P56385	http://phylomedb.org/?seqid=P56385
ProteinModelPortal	P56385	http://www.proteinmodelportal.org/query/uniprot/P56385
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19892738	http://www.ncbi.nlm.nih.gov/pubmed/19892738
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-163210	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-163210
RefSeq	NP_009031	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_009031
STRING	9606.ENSP00000306003	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000306003&targetmode=cogs
UCSC	uc003gas	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003gas&org=rat
UniGene	Hs.85539	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.85539
UniProtKB	ATP5I_HUMAN	http://www.uniprot.org/uniprot/ATP5I_HUMAN
UniProtKB-AC	P56385	http://www.uniprot.org/uniprot/P56385
charge	swissprot:ATP5I_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ATP5I_HUMAN
eggNOG	ENOG410XYSS	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XYSS
eggNOG	KOG4326	http://eggnogapi.embl.de/nog_data/html/tree/KOG4326
epestfind	swissprot:ATP5I_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ATP5I_HUMAN
garnier	swissprot:ATP5I_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ATP5I_HUMAN
helixturnhelix	swissprot:ATP5I_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATP5I_HUMAN
hmoment	swissprot:ATP5I_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ATP5I_HUMAN
iep	swissprot:ATP5I_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ATP5I_HUMAN
inforesidue	swissprot:ATP5I_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ATP5I_HUMAN
neXtProt	NX_P56385	http://www.nextprot.org/db/entry/NX_P56385
octanol	swissprot:ATP5I_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ATP5I_HUMAN
pepcoil	swissprot:ATP5I_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ATP5I_HUMAN
pepdigest	swissprot:ATP5I_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ATP5I_HUMAN
pepinfo	swissprot:ATP5I_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ATP5I_HUMAN
pepnet	swissprot:ATP5I_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ATP5I_HUMAN
pepstats	swissprot:ATP5I_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ATP5I_HUMAN
pepwheel	swissprot:ATP5I_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ATP5I_HUMAN
pepwindow	swissprot:ATP5I_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ATP5I_HUMAN
sigcleave	swissprot:ATP5I_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ATP5I_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CNGB1_HUMAN	Event=Alternative splicing; Named isoforms=4; Comment=There is no evidence for an ortholog to bovine GARP1 in the human genome.; Name=RCNC2B; IsoId=Q14028-1; Sequence=Displayed; Name=RCNC2A; IsoId=Q14028-2; Sequence=VSP_001110; Name=GARP2; Synonyms=GARP; IsoId=Q14028-3; Sequence=VSP_037921, VSP_037922; Note=In the rod cells, the CNGB1 locus encodes the cyclic nucleotide-gated cation channel beta-1 subunit and several glutamic-acid-rich proteins (GARPs).; Name=4; IsoId=Q14028-4; Sequence=VSP_053421; 
# AltName	CNGB1_HUMAN	Cyclic nucleotide-gated cation channel 4
# AltName	CNGB1_HUMAN	Cyclic nucleotide-gated cation channel gamma
# AltName	CNGB1_HUMAN	Cyclic nucleotide-gated cation channel modulatory subunit
# AltName	CNGB1_HUMAN	Cyclic nucleotide-gated channel beta-1
# AltName	CNGB1_HUMAN	Glutamic acid-rich protein
# BioGrid	107658	3
# CCDS	CCDS42169	-. [Q14028-1]
# CCDS	CCDS45495	-. [Q14028-3]
# CCDS	CCDS67042	-. [Q14028-4]
# DISEASE	CNGB1_HUMAN	Retinitis pigmentosa 45 (RP45) [MIM 613767]  A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. {ECO 0000269|PubMed 11379879}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000251102	ENSP00000251102; ENSG00000070729. [Q14028-1]
# Ensembl	ENST00000311183	ENSP00000311670; ENSG00000070729. [Q14028-3]
# Ensembl	ENST00000564448	ENSP00000454633; ENSG00000070729. [Q14028-4]
# ExpressionAtlas	Q14028	baseline and differential
# FUNCTION	CNGB1_HUMAN	Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties  it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit. 
# FUNCTION	CNGB1_HUMAN	Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP. 
# GO_component	GO:0000139	Golgi membrane; TAS:Reactome.
# GO_component	GO:0001750	photoreceptor outer segment; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0017071	intracellular cyclic nucleotide activated cation channel complex; IEA:Ensembl.
# GO_component	GO:0030660	Golgi-associated vesicle membrane; TAS:Reactome.
# GO_component	GO:0043195	terminal bouton; IEA:Ensembl.
# GO_component	GO:0060170	ciliary membrane; TAS:Reactome.
# GO_component	GO:1902495	transmembrane transporter complex; IDA:UniProtKB.
# GO_function	GO:0005222	intracellular cAMP activated cation channel activity; IBA:GO_Central.
# GO_function	GO:0005223	intracellular cGMP activated cation channel activity; IDA:UniProtKB.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IBA:GO_Central.
# GO_function	GO:0015276	ligand-gated ion channel activity; TAS:ProtInc.
# GO_function	GO:0030552	cAMP binding; IEA:UniProtKB-KW.
# GO_function	GO:0030553	cGMP binding; IDA:UniProtKB.
# GO_process	GO:0001895	retina homeostasis; IMP:UniProtKB.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006812	cation transport; IDA:UniProtKB.
# GO_process	GO:0007601	visual perception; TAS:ProtInc.
# GO_process	GO:0007608	sensory perception of smell; IEA:UniProtKB-KW.
# GO_process	GO:0016056	rhodopsin mediated signaling pathway; TAS:Reactome.
# GO_process	GO:0022400	regulation of rhodopsin mediated signaling pathway; TAS:Reactome.
# GO_process	GO:0033365	protein localization to organelle; IEA:Ensembl.
# GO_process	GO:0035845	photoreceptor cell outer segment organization; IEA:Ensembl.
# GO_process	GO:0042391	regulation of membrane potential; IBA:GO_Central.
# GO_process	GO:0045494	photoreceptor cell maintenance; IEA:Ensembl.
# GO_process	GO:0050908	detection of light stimulus involved in visual perception; IMP:UniProtKB.
# GO_process	GO:0051290	protein heterotetramerization; IEA:Ensembl.
# GO_process	GO:0051480	regulation of cytosolic calcium ion concentration; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0050877	neurological system process
# Gene3D	2.60.120.10	-; 1.
# Genevisible	Q14028	HS
# HGNC	HGNC:2151	CNGB1
# INTERACTION	CNGB1_HUMAN	Q5ICW4 GRB14 (xeno); NbExp=2; IntAct=EBI-7959609, EBI-7639273; 
# IntAct	Q14028	2
# InterPro	IPR000595	cNMP-bd_dom
# InterPro	IPR014710	RmlC-like_jellyroll
# InterPro	IPR018488	cNMP-bd_CS
# InterPro	IPR018490	cNMP-bd-like
# InterPro	IPR032944	CNGB1
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00527	[Inherited metabolic disease; Nervous system disease; Eye disease] Retinitis pigmentosa (RP)
# KEGG_Pathway	ko04740	Olfactory transduction
# KEGG_Pathway	ko04744	Phototransduction
# MIM	600724	gene
# MIM	613767	phenotype
# Organism	CNGB1_HUMAN	Homo sapiens (Human)
# Orphanet	791	Retinitis pigmentosa
# PANTHER	PTHR10217:SF386	PTHR10217:SF386
# PIR	A57652	A57652
# PIR	S32538	S32538
# PIR	S69275	S69275
# PROSITE	PS00888	CNMP_BINDING_1
# PROSITE	PS00889	CNMP_BINDING_2
# PROSITE	PS50042	CNMP_BINDING_3
# Pfam	PF00027	cNMP_binding
# Proteomes	UP000005640	Chromosome 16
# Reactome	R-HSA-2485179	Activation of the phototransduction cascade
# Reactome	R-HSA-2514859	Inactivation, recovery and regulation of the phototransduction cascade
# Reactome	R-HSA-5620916	VxPx cargo-targeting to cilium
# RecName	CNGB1_HUMAN	Cyclic nucleotide-gated cation channel beta-1
# RefSeq	NP_001129111	NM_001135639.1. [Q14028-3]
# RefSeq	NP_001273059	NM_001286130.1. [Q14028-4]
# RefSeq	NP_001288	NM_001297.4. [Q14028-1]
# SIMILARITY	Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGB1 subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 cyclic nucleotide-binding domain. {ECO:0000255|PROSITE-ProRule	PRU00060}.
# SMART	SM00100	cNMP
# SUBCELLULAR LOCATION	CNGB1_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Tetramer formed of three CNGA1 and one CNGB1 modulatory subunits. {ECO	0000250}. 
# SUPFAM	SSF51206	SSF51206
# TCDB	1.A.1.5	the voltage-gated ion channel (vic) superfamily
# UCSC	uc002emt	human. [Q14028-1]
# eggNOG	ENOG410ZJ5U	LUCA
# eggNOG	KOG0499	Eukaryota
BLAST	swissprot:CNGB1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CNGB1_HUMAN
BioCyc	ZFISH:ENSG00000070729-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000070729-MONOMER
COXPRESdb	1258	http://coxpresdb.jp/data/gene/1258.shtml
CleanEx	HS_CNGB1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CNGB1
DOI	10.1006/geno.1995.1102	http://dx.doi.org/10.1006/geno.1995.1102
DOI	10.1007/s004390100496	http://dx.doi.org/10.1007/s004390100496
DOI	10.1016/0014-5793(96)00588-1	http://dx.doi.org/10.1016/0014-5793(96)00588-1
DOI	10.1016/S0378-1119(00)00023-8	http://dx.doi.org/10.1016/S0378-1119(00)00023-8
DOI	10.1038/362764a0	http://dx.doi.org/10.1038/362764a0
DOI	10.1038/nature03187	http://dx.doi.org/10.1038/nature03187
DOI	10.1038/nn1266	http://dx.doi.org/10.1038/nn1266
DOI	10.1074/jbc.273.15.9148	http://dx.doi.org/10.1074/jbc.273.15.9148
DOI	10.1074/jbc.M505012200	http://dx.doi.org/10.1074/jbc.M505012200
DOI	10.1074/jbc.M507488200	http://dx.doi.org/10.1074/jbc.M507488200
EMBL	AC010543	http://www.ebi.ac.uk/ena/data/view/AC010543
EMBL	AF042498	http://www.ebi.ac.uk/ena/data/view/AF042498
EMBL	CH471092	http://www.ebi.ac.uk/ena/data/view/CH471092
EMBL	L15296	http://www.ebi.ac.uk/ena/data/view/L15296
EMBL	L15297	http://www.ebi.ac.uk/ena/data/view/L15297
EMBL	U18945	http://www.ebi.ac.uk/ena/data/view/U18945
EMBL	U58837	http://www.ebi.ac.uk/ena/data/view/U58837
Ensembl	ENST00000251102	http://www.ensembl.org/id/ENST00000251102
Ensembl	ENST00000311183	http://www.ensembl.org/id/ENST00000311183
Ensembl	ENST00000564448	http://www.ensembl.org/id/ENST00000564448
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0001750	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001750
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0017071	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017071
GO_component	GO:0030660	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030660
GO_component	GO:0043195	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043195
GO_component	GO:0060170	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060170
GO_component	GO:1902495	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902495
GO_function	GO:0005222	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005222
GO_function	GO:0005223	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005223
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_function	GO:0030552	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030552
GO_function	GO:0030553	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030553
GO_process	GO:0001895	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001895
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006812	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006812
GO_process	GO:0007601	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007601
GO_process	GO:0007608	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007608
GO_process	GO:0016056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016056
GO_process	GO:0022400	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022400
GO_process	GO:0033365	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033365
GO_process	GO:0035845	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035845
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0045494	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045494
GO_process	GO:0050908	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050908
GO_process	GO:0051290	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051290
GO_process	GO:0051480	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051480
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
Gene3D	2.60.120.10	http://www.cathdb.info/version/latest/superfamily/2.60.120.10
GeneCards	CNGB1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CNGB1
GeneID	1258	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1258
GeneTree	ENSGT00760000118772	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118772
H-InvDB	HIX0038536	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0038536
HGNC	HGNC:2151	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2151
HOGENOM	HOG000231425	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231425&db=HOGENOM6
HOVERGEN	HBG051038	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051038&db=HOVERGEN
HPA	HPA039159	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA039159
HPA	HPA060355	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA060355
InParanoid	Q14028	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q14028
IntAct	Q14028	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q14028*
InterPro	IPR000595	http://www.ebi.ac.uk/interpro/entry/IPR000595
InterPro	IPR014710	http://www.ebi.ac.uk/interpro/entry/IPR014710
InterPro	IPR018488	http://www.ebi.ac.uk/interpro/entry/IPR018488
InterPro	IPR018490	http://www.ebi.ac.uk/interpro/entry/IPR018490
InterPro	IPR032944	http://www.ebi.ac.uk/interpro/entry/IPR032944
Jabion	1258	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1258
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00527	http://www.genome.jp/dbget-bin/www_bget?H00527
KEGG_Gene	hsa:1258	http://www.genome.jp/dbget-bin/www_bget?hsa:1258
KEGG_Orthology	KO:K04952	http://www.genome.jp/dbget-bin/www_bget?KO:K04952
KEGG_Pathway	ko04740	http://www.genome.jp/kegg-bin/show_pathway?ko04740
KEGG_Pathway	ko04744	http://www.genome.jp/kegg-bin/show_pathway?ko04744
MIM	600724	http://www.ncbi.nlm.nih.gov/omim/600724
MIM	613767	http://www.ncbi.nlm.nih.gov/omim/613767
MINT	MINT-4853474	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4853474
OMA	WEDAHQD	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WEDAHQD
Orphanet	791	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=791
OrthoDB	EOG091G03EW	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G03EW
PANTHER	PTHR10217:SF386	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10217:SF386
PROSITE	PS00888	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00888
PROSITE	PS00889	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00889
PROSITE	PS50042	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50042
PSORT	swissprot:CNGB1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CNGB1_HUMAN
PSORT-B	swissprot:CNGB1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CNGB1_HUMAN
PSORT2	swissprot:CNGB1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CNGB1_HUMAN
Pfam	PF00027	http://pfam.xfam.org/family/PF00027
PharmGKB	PA26662	http://www.pharmgkb.org/do/serve?objId=PA26662&objCls=Gene
Phobius	swissprot:CNGB1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CNGB1_HUMAN
PhylomeDB	Q14028	http://phylomedb.org/?seqid=Q14028
ProteinModelPortal	Q14028	http://www.proteinmodelportal.org/query/uniprot/Q14028
PubMed	10717482	http://www.ncbi.nlm.nih.gov/pubmed/10717482
PubMed	11379879	http://www.ncbi.nlm.nih.gov/pubmed/11379879
PubMed	15195096	http://www.ncbi.nlm.nih.gov/pubmed/15195096
PubMed	15616553	http://www.ncbi.nlm.nih.gov/pubmed/15616553
PubMed	16280326	http://www.ncbi.nlm.nih.gov/pubmed/16280326
PubMed	16407240	http://www.ncbi.nlm.nih.gov/pubmed/16407240
PubMed	7590744	http://www.ncbi.nlm.nih.gov/pubmed/7590744
PubMed	7682292	http://www.ncbi.nlm.nih.gov/pubmed/7682292
PubMed	8766832	http://www.ncbi.nlm.nih.gov/pubmed/8766832
PubMed	9535905	http://www.ncbi.nlm.nih.gov/pubmed/9535905
Reactome	R-HSA-2485179	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2485179
Reactome	R-HSA-2514859	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2514859
Reactome	R-HSA-5620916	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5620916
RefSeq	NP_001129111	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001129111
RefSeq	NP_001273059	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273059
RefSeq	NP_001288	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001288
SMART	SM00100	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00100
SMR	Q14028	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q14028
STRING	9606.ENSP00000251102	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000251102&targetmode=cogs
SUPFAM	SSF51206	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51206
TCDB	1.A.1.5	http://www.tcdb.org/search/result.php?tc=1.A.1.5
UCSC	uc002emt	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002emt&org=rat
UniGene	Hs.147062	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.147062
UniProtKB	CNGB1_HUMAN	http://www.uniprot.org/uniprot/CNGB1_HUMAN
UniProtKB-AC	Q14028	http://www.uniprot.org/uniprot/Q14028
charge	swissprot:CNGB1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CNGB1_HUMAN
eggNOG	ENOG410ZJ5U	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZJ5U
eggNOG	KOG0499	http://eggnogapi.embl.de/nog_data/html/tree/KOG0499
epestfind	swissprot:CNGB1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CNGB1_HUMAN
garnier	swissprot:CNGB1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CNGB1_HUMAN
helixturnhelix	swissprot:CNGB1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CNGB1_HUMAN
hmoment	swissprot:CNGB1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CNGB1_HUMAN
iep	swissprot:CNGB1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CNGB1_HUMAN
inforesidue	swissprot:CNGB1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CNGB1_HUMAN
neXtProt	NX_Q14028	http://www.nextprot.org/db/entry/NX_Q14028
octanol	swissprot:CNGB1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CNGB1_HUMAN
pepcoil	swissprot:CNGB1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CNGB1_HUMAN
pepdigest	swissprot:CNGB1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CNGB1_HUMAN
pepinfo	swissprot:CNGB1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CNGB1_HUMAN
pepnet	swissprot:CNGB1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CNGB1_HUMAN
pepstats	swissprot:CNGB1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CNGB1_HUMAN
pepwheel	swissprot:CNGB1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CNGB1_HUMAN
pepwindow	swissprot:CNGB1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CNGB1_HUMAN
sigcleave	swissprot:CNGB1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CNGB1_HUMAN
## Database	ID	URL or Descriptions
# AltName	CCG7_HUMAN	Neuronal voltage-gated calcium channel gamma-7 subunit
# AltName	CCG7_HUMAN	Transmembrane AMPAR regulatory protein gamma-7
# Ensembl	ENST00000222212	ENSP00000222212; ENSG00000105605
# Ensembl	ENST00000391767	ENSP00000375647; ENSG00000105605
# ExpressionAtlas	P62955	baseline and differential
# FUNCTION	CCG7_HUMAN	Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity only for GRIA1 and GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state. {ECO 0000269|PubMed 21172611}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005891	voltage-gated calcium channel complex; NAS:UniProtKB.
# GO_component	GO:0032281	AMPA glutamate receptor complex; ISS:UniProtKB.
# GO_function	GO:0005245	voltage-gated calcium channel activity; NAS:UniProtKB.
# GO_function	GO:0016247	channel regulator activity; IBA:GO_Central.
# GO_process	GO:0006816	calcium ion transport; NAS:UniProtKB.
# GO_process	GO:0019226	transmission of nerve impulse; IBA:GO_Central.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:0070588	calcium ion transmembrane transport; IBA:GO_Central.
# GO_process	GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P62955	HS
# HGNC	HGNC:13626	CACNG7
# InterPro	IPR004031	PMP22/EMP/MP20/Claudin
# InterPro	IPR008368	VDCC_gsu
# InterPro	IPR008371	VDCC_g7su
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04010	MAPK signaling pathway
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05410	Hypertrophic cardiomyopathy (HCM)
# KEGG_Pathway	ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
# KEGG_Pathway	ko05414	Dilated cardiomyopathy
# MIM	606899	gene
# Organism	CCG7_HUMAN	Homo sapiens (Human)
# PRINTS	PR01792	VDCCGAMMA
# PRINTS	PR01795	VDCCGAMMA7
# Pfam	PF13903	Claudin_2
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# Reactome	R-HSA-5576893	Phase 2 - plateau phase
# Reactome	R-HSA-5576894	Phase 1 - inactivation of fast Na+ channels
# RecName	CCG7_HUMAN	Voltage-dependent calcium channel gamma-7 subunit
# RefSeq	NP_114102	NM_031896.4
# RefSeq	XP_016882582	XM_017027093.1
# SIMILARITY	Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	CCG7_HUMAN	Membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUBUNIT	The L-type calcium channel is composed of five subunits	 alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5 and CACNG8. 
# TCDB	8.A.16.2	the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family
# TISSUE SPECIFICITY	Widely expressed. {ECO:0000269|PubMed	11170751}. 
# UCSC	uc002qcr	human
# eggNOG	ENOG410IXFC	Eukaryota
# eggNOG	ENOG410XUAQ	LUCA
BLAST	swissprot:CCG7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CCG7_HUMAN
BioCyc	ZFISH:ENSG00000105605-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000105605-MONOMER
COXPRESdb	59284	http://coxpresdb.jp/data/gene/59284.shtml
CleanEx	HS_CACNG7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CACNG7
DOI	10.1006/geno.2000.6440	http://dx.doi.org/10.1006/geno.2000.6440
DOI	10.1016/S0378-1119(01)00738-7	http://dx.doi.org/10.1016/S0378-1119(01)00738-7
DOI	10.1016/j.neuron.2010.11.026	http://dx.doi.org/10.1016/j.neuron.2010.11.026
DOI	10.1093/emboj/21.7.1514	http://dx.doi.org/10.1093/emboj/21.7.1514
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF288387	http://www.ebi.ac.uk/ena/data/view/AF288387
EMBL	AF361353	http://www.ebi.ac.uk/ena/data/view/AF361353
EMBL	AF458897	http://www.ebi.ac.uk/ena/data/view/AF458897
EMBL	BC069332	http://www.ebi.ac.uk/ena/data/view/BC069332
EMBL	BC093869	http://www.ebi.ac.uk/ena/data/view/BC093869
EMBL	BC113503	http://www.ebi.ac.uk/ena/data/view/BC113503
Ensembl	ENST00000222212	http://www.ensembl.org/id/ENST00000222212
Ensembl	ENST00000391767	http://www.ensembl.org/id/ENST00000391767
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005891
GO_component	GO:0032281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032281
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0016247	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016247
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0019226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019226
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:2000311	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000311
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	CACNG7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CACNG7
GeneID	59284	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=59284
GeneTree	ENSGT00550000074547	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074547
HGNC	HGNC:13626	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13626
HOGENOM	HOG000233439	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233439&db=HOGENOM6
HOVERGEN	HBG025923	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG025923&db=HOVERGEN
HPA	HPA049881	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA049881
InParanoid	P62955	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P62955
InterPro	IPR004031	http://www.ebi.ac.uk/interpro/entry/IPR004031
InterPro	IPR008368	http://www.ebi.ac.uk/interpro/entry/IPR008368
InterPro	IPR008371	http://www.ebi.ac.uk/interpro/entry/IPR008371
Jabion	59284	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=59284
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:59284	http://www.genome.jp/dbget-bin/www_bget?hsa:59284
KEGG_Orthology	KO:K04872	http://www.genome.jp/dbget-bin/www_bget?KO:K04872
KEGG_Pathway	ko04010	http://www.genome.jp/kegg-bin/show_pathway?ko04010
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05410	http://www.genome.jp/kegg-bin/show_pathway?ko05410
KEGG_Pathway	ko05412	http://www.genome.jp/kegg-bin/show_pathway?ko05412
KEGG_Pathway	ko05414	http://www.genome.jp/kegg-bin/show_pathway?ko05414
MIM	606899	http://www.ncbi.nlm.nih.gov/omim/606899
OMA	VHMSASP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VHMSASP
OrthoDB	EOG091G0F73	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0F73
PRINTS	PR01792	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01792
PRINTS	PR01795	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01795
PSORT	swissprot:CCG7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CCG7_HUMAN
PSORT-B	swissprot:CCG7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CCG7_HUMAN
PSORT2	swissprot:CCG7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CCG7_HUMAN
Pfam	PF13903	http://pfam.xfam.org/family/PF13903
PharmGKB	PA26021	http://www.pharmgkb.org/do/serve?objId=PA26021&objCls=Gene
Phobius	swissprot:CCG7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CCG7_HUMAN
PhylomeDB	P62955	http://phylomedb.org/?seqid=P62955
ProteinModelPortal	P62955	http://www.proteinmodelportal.org/query/uniprot/P62955
PubMed	11170751	http://www.ncbi.nlm.nih.gov/pubmed/11170751
PubMed	11738816	http://www.ncbi.nlm.nih.gov/pubmed/11738816
PubMed	11927536	http://www.ncbi.nlm.nih.gov/pubmed/11927536
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21172611	http://www.ncbi.nlm.nih.gov/pubmed/21172611
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
Reactome	R-HSA-5576893	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576893
Reactome	R-HSA-5576894	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576894
RefSeq	NP_114102	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_114102
RefSeq	XP_016882582	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016882582
STRING	9606.ENSP00000222212	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000222212&targetmode=cogs
TCDB	8.A.16.2	http://www.tcdb.org/search/result.php?tc=8.A.16.2
UCSC	uc002qcr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002qcr&org=rat
UniGene	Hs.631597	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.631597
UniProtKB	CCG7_HUMAN	http://www.uniprot.org/uniprot/CCG7_HUMAN
UniProtKB-AC	P62955	http://www.uniprot.org/uniprot/P62955
charge	swissprot:CCG7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CCG7_HUMAN
eggNOG	ENOG410IXFC	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IXFC
eggNOG	ENOG410XUAQ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XUAQ
epestfind	swissprot:CCG7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CCG7_HUMAN
garnier	swissprot:CCG7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CCG7_HUMAN
helixturnhelix	swissprot:CCG7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CCG7_HUMAN
hmoment	swissprot:CCG7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CCG7_HUMAN
iep	swissprot:CCG7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CCG7_HUMAN
inforesidue	swissprot:CCG7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CCG7_HUMAN
neXtProt	NX_P62955	http://www.nextprot.org/db/entry/NX_P62955
octanol	swissprot:CCG7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CCG7_HUMAN
pepcoil	swissprot:CCG7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CCG7_HUMAN
pepdigest	swissprot:CCG7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CCG7_HUMAN
pepinfo	swissprot:CCG7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CCG7_HUMAN
pepnet	swissprot:CCG7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CCG7_HUMAN
pepstats	swissprot:CCG7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CCG7_HUMAN
pepwheel	swissprot:CCG7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CCG7_HUMAN
pepwindow	swissprot:CCG7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CCG7_HUMAN
sigcleave	swissprot:CCG7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CCG7_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	BAX_HUMAN	Event=Alternative splicing; Named isoforms=8; Name=Alpha; IsoId=Q07812-1; Sequence=Displayed; Name=Beta; IsoId=Q07812-2, Q07814-1; Sequence=VSP_031237; Name=Gamma; IsoId=Q07812-3, Q07815-1; Sequence=VSP_031234, VSP_031236; Name=Delta; IsoId=Q07812-4, P55269-1; Sequence=VSP_031235; Name=Epsilon; IsoId=Q07812-5; Sequence=VSP_031240; Name=Zeta; IsoId=Q07812-6; Sequence=VSP_031239; Name=Psi; IsoId=Q07812-7; Sequence=VSP_031238; Name=Sigma; IsoId=Q07812-8; Sequence=VSP_037475; 
# AltName	BAX_HUMAN	Bcl-2-like protein 4
# BioGrid	107057	76
# CCDS	CCDS12742	-. [Q07812-1]
# CCDS	CCDS12743	-. [Q07812-4]
# CCDS	CCDS12744	-. [Q07812-2]
# CCDS	CCDS12745	-. [Q07812-8]
# ChiTaRS	BAX	human
# DOMAIN	BAX_HUMAN	Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family. {ECO 0000250}. 
# Ensembl	ENST00000293288	ENSP00000293288; ENSG00000087088. [Q07812-2]
# Ensembl	ENST00000345358	ENSP00000263262; ENSG00000087088. [Q07812-1]
# Ensembl	ENST00000354470	ENSP00000346461; ENSG00000087088. [Q07812-4]
# Ensembl	ENST00000356483	ENSP00000348871; ENSG00000087088. [Q07812-5]
# Ensembl	ENST00000415969	ENSP00000389971; ENSG00000087088. [Q07812-8]
# Ensembl	ENST00000515540	ENSP00000426328; ENSG00000087088. [Q07812-3]
# ExpressionAtlas	Q07812	baseline and differential
# FUNCTION	BAX_HUMAN	Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. {ECO 0000269|PubMed 10772918, ECO 0000269|PubMed 16113678, ECO 0000269|PubMed 18948948, ECO 0000269|PubMed 21199865, ECO 0000269|PubMed 8358790, ECO 0000269|PubMed 8521816}. 
# GO_component	GO:0005634	nucleus; IMP:UniProtKB.
# GO_component	GO:0005635	nuclear envelope; IDA:AgBase.
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005741	mitochondrial outer membrane; IBA:GO_Central.
# GO_component	GO:0005757	mitochondrial permeability transition pore complex; IDA:HGNC.
# GO_component	GO:0005783	endoplasmic reticulum; IDA:HGNC.
# GO_component	GO:0005789	endoplasmic reticulum membrane; IDA:HGNC.
# GO_component	GO:0005829	cytosol; IDA:UniProtKB.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0046930	pore complex; IDA:BHF-UCL.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_component	GO:0097136	Bcl-2 family protein complex; IDA:UniProtKB.
# GO_component	GO:0097144	BAX complex; IDA:UniProtKB.
# GO_function	GO:0008289	lipid binding; IDA:HGNC.
# GO_function	GO:0015267	channel activity; IDA:BHF-UCL.
# GO_function	GO:0042802	identical protein binding; IPI:IntAct.
# GO_function	GO:0042803	protein homodimerization activity; IDA:HGNC.
# GO_function	GO:0046982	protein heterodimerization activity; IPI:HGNC.
# GO_function	GO:0051434	BH3 domain binding; IDA:UniProtKB.
# GO_process	GO:0001541	ovarian follicle development; IEA:Ensembl.
# GO_process	GO:0001764	neuron migration; IEA:Ensembl.
# GO_process	GO:0001777	T cell homeostatic proliferation; IEA:Ensembl.
# GO_process	GO:0001782	B cell homeostasis; IEA:Ensembl.
# GO_process	GO:0001783	B cell apoptotic process; IDA:HGNC.
# GO_process	GO:0001822	kidney development; IEA:Ensembl.
# GO_process	GO:0001836	release of cytochrome c from mitochondria; IDA:BHF-UCL.
# GO_process	GO:0001844	protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; TAS:Reactome.
# GO_process	GO:0001974	blood vessel remodeling; IEA:Ensembl.
# GO_process	GO:0002262	myeloid cell homeostasis; IEA:Ensembl.
# GO_process	GO:0002352	B cell negative selection; IEA:Ensembl.
# GO_process	GO:0002358	B cell homeostatic proliferation; IEA:Ensembl.
# GO_process	GO:0002904	positive regulation of B cell apoptotic process; IEA:Ensembl.
# GO_process	GO:0006687	glycosphingolipid metabolic process; IEA:Ensembl.
# GO_process	GO:0006808	regulation of nitrogen utilization; IEA:Ensembl.
# GO_process	GO:0006915	apoptotic process; NAS:UniProtKB.
# GO_process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:HGNC.
# GO_process	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; TAS:Reactome.
# GO_process	GO:0006987	activation of signaling protein activity involved in unfolded protein response; TAS:ParkinsonsUK-UCL.
# GO_process	GO:0007281	germ cell development; IEA:Ensembl.
# GO_process	GO:0008053	mitochondrial fusion; IDA:HGNC.
# GO_process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors; IC:BHF-UCL.
# GO_process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage; IBA:GO_Central.
# GO_process	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; IDA:HGNC.
# GO_process	GO:0008637	apoptotic mitochondrial changes; IDA:HGNC.
# GO_process	GO:0009566	fertilization; IEA:Ensembl.
# GO_process	GO:0009636	response to toxic substance; IDA:HGNC.
# GO_process	GO:0009651	response to salt stress; IEA:Ensembl.
# GO_process	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient; IDA:HGNC.
# GO_process	GO:0010332	response to gamma radiation; IEA:Ensembl.
# GO_process	GO:0016032	viral process; IEA:UniProtKB-KW.
# GO_process	GO:0021854	hypothalamus development; IEA:Ensembl.
# GO_process	GO:0021987	cerebral cortex development; IEA:Ensembl.
# GO_process	GO:0032091	negative regulation of protein binding; IDA:UniProtKB.
# GO_process	GO:0032461	positive regulation of protein oligomerization; IDA:UniProtKB.
# GO_process	GO:0032469	endoplasmic reticulum calcium ion homeostasis; TAS:UniProtKB.
# GO_process	GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration; IEA:Ensembl.
# GO_process	GO:0032976	release of matrix enzymes from mitochondria; IDA:HGNC.
# GO_process	GO:0033137	negative regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
# GO_process	GO:0033599	regulation of mammary gland epithelial cell proliferation; IEA:Ensembl.
# GO_process	GO:0034644	cellular response to UV; IEA:Ensembl.
# GO_process	GO:0035234	ectopic germ cell programmed cell death; IEA:Ensembl.
# GO_process	GO:0042475	odontogenesis of dentin-containing tooth; IEA:Ensembl.
# GO_process	GO:0042981	regulation of apoptotic process; TAS:Reactome.
# GO_process	GO:0043065	positive regulation of apoptotic process; IMP:UniProtKB.
# GO_process	GO:0043496	regulation of protein homodimerization activity; IDA:HGNC.
# GO_process	GO:0043497	regulation of protein heterodimerization activity; IPI:HGNC.
# GO_process	GO:0043524	negative regulation of neuron apoptotic process; IEA:Ensembl.
# GO_process	GO:0043525	positive regulation of neuron apoptotic process; IDA:HGNC.
# GO_process	GO:0043653	mitochondrial fragmentation involved in apoptotic process; IDA:HGNC.
# GO_process	GO:0045136	development of secondary sexual characteristics; IEA:Ensembl.
# GO_process	GO:0046666	retinal cell programmed cell death; IEA:Ensembl.
# GO_process	GO:0048087	positive regulation of developmental pigmentation; IEA:Ensembl.
# GO_process	GO:0048147	negative regulation of fibroblast proliferation; IEA:Ensembl.
# GO_process	GO:0048515	spermatid differentiation; IEA:Ensembl.
# GO_process	GO:0048597	post-embryonic camera-type eye morphogenesis; IEA:Ensembl.
# GO_process	GO:0048678	response to axon injury; IEA:Ensembl.
# GO_process	GO:0048873	homeostasis of number of cells within a tissue; IEA:Ensembl.
# GO_process	GO:0051259	protein oligomerization; IDA:UniProtKB.
# GO_process	GO:0051260	protein homooligomerization; IDA:UniProtKB.
# GO_process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol; IEA:Ensembl.
# GO_process	GO:0051402	neuron apoptotic process; IEA:Ensembl.
# GO_process	GO:0051881	regulation of mitochondrial membrane potential; IDA:HGNC.
# GO_process	GO:0060011	Sertoli cell proliferation; IEA:Ensembl.
# GO_process	GO:0060041	retina development in camera-type eye; IEA:Ensembl.
# GO_process	GO:0060058	positive regulation of apoptotic process involved in mammary gland involution; IEA:Ensembl.
# GO_process	GO:0060068	vagina development; IEA:Ensembl.
# GO_process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IMP:UniProtKB.
# GO_process	GO:0070242	thymocyte apoptotic process; IEA:Ensembl.
# GO_process	GO:0070584	mitochondrion morphogenesis; IEA:Ensembl.
# GO_process	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator; IEA:Ensembl.
# GO_process	GO:0090200	positive regulation of release of cytochrome c from mitochondria; IDA:UniProtKB.
# GO_process	GO:0097190	apoptotic signaling pathway; IDA:HGNC.
# GO_process	GO:0097191	extrinsic apoptotic signaling pathway; IDA:BHF-UCL.
# GO_process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand; IBA:GO_Central.
# GO_process	GO:0097193	intrinsic apoptotic signaling pathway; IDA:HGNC.
# GO_process	GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; IEA:Ensembl.
# GO_process	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response; IMP:UniProtKB.
# GO_process	GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; TAS:Reactome.
# GO_process	GO:1902262	apoptotic process involved in patterning of blood vessels; IEA:Ensembl.
# GO_process	GO:1902263	apoptotic process involved in embryonic digit morphogenesis; IEA:Ensembl.
# GO_process	GO:1902445	regulation of mitochondrial membrane permeability involved in programmed necrotic cell death; IEA:Ensembl.
# GO_process	GO:1902512	positive regulation of apoptotic DNA fragmentation; IMP:BHF-UCL.
# GO_process	GO:1903896	positive regulation of IRE1-mediated unfolded protein response; TAS:ParkinsonsUK-UCL.
# GO_process	GO:1990117	B cell receptor apoptotic signaling pathway; IDA:BHF-UCL.
# GO_process	GO:2001234	negative regulation of apoptotic signaling pathway; IEA:Ensembl.
# GO_process	GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
# GO_process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005635	nuclear envelope
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008289	lipid binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007005	mitochondrion organization
# GOslim_process	GO:0007155	cell adhesion
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0008219	cell death
# GOslim_process	GO:0008283	cell proliferation
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0048870	cell motility
# GOslim_process	GO:0055085	transmembrane transport
# GOslim_process	GO:0061024	membrane organization
# Genevisible	Q07812	HS
# HGNC	HGNC:959	BAX
# INTERACTION	BAX_HUMAN	Self; NbExp=27; IntAct=EBI-516580, EBI-516580; P26662 - (xeno); NbExp=3; IntAct=EBI-516580, EBI-9099462; Q16611 BAK1; NbExp=5; IntAct=EBI-516580, EBI-519866; P10415 BCL2; NbExp=11; IntAct=EBI-516580, EBI-77694; Q07817 BCL2L1; NbExp=4; IntAct=EBI-516580, EBI-78035; Q07817-1 BCL2L1; NbExp=13; IntAct=EBI-516580, EBI-287195; O43521 BCL2L11; NbExp=19; IntAct=EBI-516580, EBI-526406; Q92843 BCL2L2; NbExp=3; IntAct=EBI-516580, EBI-707714; P55957 BID; NbExp=16; IntAct=EBI-516580, EBI-519672; P70444 Bid (xeno); NbExp=2; IntAct=EBI-516580, EBI-2128640; Q7L3V2 BOP; NbExp=2; IntAct=EBI-516580, EBI-10697720; O75460 ERN1; NbExp=2; IntAct=EBI-516580, EBI-371750; Q07820 MCL1; NbExp=6; IntAct=EBI-516580, EBI-1003422; P97287 Mcl1 (xeno); NbExp=2; IntAct=EBI-516580, EBI-707292; Q9ULZ3 PYCARD; NbExp=7; IntAct=EBI-516580, EBI-751215; Q7Z419 RNF144B; NbExp=5; IntAct=EBI-516580, EBI-2129982; Q9Y371-1 SH3GLB1; NbExp=2; IntAct=EBI-516580, EBI-5291808; P49334 TOM22 (xeno); NbExp=3; IntAct=EBI-516580, EBI-12527; P23644 TOM40 (xeno); NbExp=2; IntAct=EBI-516580, EBI-12539; P24391 tom40 (xeno); NbExp=2; IntAct=EBI-516580, EBI-1791540; P07213 TOM70 (xeno); NbExp=2; IntAct=EBI-516580, EBI-12551; Q9P2Y5 UVRAG; NbExp=6; IntAct=EBI-516580, EBI-2952704; P17361 VACWR028 (xeno); NbExp=3; IntAct=EBI-516580, EBI-7115640; P12956 XRCC6; NbExp=2; IntAct=EBI-516580, EBI-353208; 
# IntAct	Q07812	57
# InterPro	IPR002475	Bcl2-like
# InterPro	IPR020717	Bcl2_BH1_motif_CS
# InterPro	IPR020726	Bcl2_BH2_motif_CS
# InterPro	IPR020728	Bcl2_BH3_motif_CS
# InterPro	IPR026298	Blc2_fam
# InterPro	IPR026304	BAX
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Disease	H00020	[Cancer] Colorectal cancer
# KEGG_Pathway	ko04115	p53 signaling pathway
# KEGG_Pathway	ko04141	Protein processing in endoplasmic reticulum
# KEGG_Pathway	ko04210	Apoptosis
# KEGG_Pathway	ko04722	Neurotrophin signaling pathway
# KEGG_Pathway	ko05014	Amyotrophic lateral sclerosis (ALS)
# KEGG_Pathway	ko05016	Huntington's disease
# KEGG_Pathway	ko05020	Prion diseases
# KEGG_Pathway	ko05152	Tuberculosis
# KEGG_Pathway	ko05161	Hepatitis B
# KEGG_Pathway	ko05166	HTLV-I infection
# KEGG_Pathway	ko05200	Pathways in cancer
# KEGG_Pathway	ko05203	Viral carcinogenesis
# KEGG_Pathway	ko05210	Colorectal cancer
# MIM	600040	gene
# Organism	BAX_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11256	PTHR11256
# PANTHER	PTHR11256:SF44	PTHR11256:SF44
# PDB	1F16	NMR; -; A=1-192
# PDB	2G5B	X-ray; 2.30 A; I/J/K/L=13-19
# PDB	2K7W	NMR; -; A=1-192
# PDB	2LR1	NMR; -; A=1-192
# PDB	3PK1	X-ray; 2.49 A; B/D=48-81
# PDB	3PL7	X-ray; 2.61 A; C=48-81
# PDB	4BD2	X-ray; 2.21 A; A=1-171
# PDB	4BD6	X-ray; 2.49 A; A=1-171, C=48-81
# PDB	4BD7	X-ray; 2.80 A; A/B/C/D=1-171
# PDB	4BD8	X-ray; 2.22 A; A/B/C/D=1-171
# PDB	4BDU	X-ray; 3.00 A; A/B/C/D=53-128
# PDB	4S0O	X-ray; 1.90 A; A/B=1-192
# PDB	4S0P	X-ray; 3.25 A; A/B=1-192
# PDB	4UF2	X-ray; 3.00 A; B=50-77
# PDB	4ZIE	X-ray; 1.80 A; A=1-166
# PDB	4ZIF	X-ray; 2.40 A; A=1-166
# PDB	4ZIG	X-ray; 2.20 A; A=1-166
# PDB	4ZIH	X-ray; 2.50 A; A=1-164
# PDB	4ZII	X-ray; 2.19 A; A=1-170
# PIR	A47538	A47538
# PIR	B47538	B47538
# PIR	C47538	C47538
# PIR	I38921	I38921
# PIR	JC7255	JC7255
# PRINTS	PR01862	BCL2FAMILY
# PROSITE	PS01080	BH1
# PROSITE	PS01258	BH2
# PROSITE	PS01259	BH3
# PROSITE	PS50062	BCL2_FAMILY
# Pfam	PF00452	Bcl-2
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-114294	Activation, translocation and oligomerization of BAX
# Reactome	R-HSA-6803204	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
# Reactome	R-HSA-6804114	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
# RecName	BAX_HUMAN	Apoptosis regulator BAX
# RefSeq	NP_001278357	NM_001291428.1
# RefSeq	NP_001278360	NM_001291431.1. [Q07812-6]
# RefSeq	NP_004315	NM_004324.3. [Q07812-2]
# RefSeq	NP_620116	NM_138761.3. [Q07812-1]
# RefSeq	NP_620118	NM_138763.3. [Q07812-4]
# RefSeq	NP_620119	NM_138764.4. [Q07812-8]
# RefSeq	XP_016882566	XM_017027077.1. [Q07812-7]
# SIMILARITY	Belongs to the Bcl-2 family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	BAX_HUMAN	Isoform Alpha  Mitochondrion membrane; Single-pass membrane protein. Cytoplasm. Note=Colocalizes with 14- 3-3 proteins in the cytoplasm. Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane. 
# SUBCELLULAR LOCATION	BAX_HUMAN	Isoform Beta  Cytoplasm. 
# SUBCELLULAR LOCATION	BAX_HUMAN	Isoform Delta  Cytoplasm {ECO 0000305}. 
# SUBCELLULAR LOCATION	BAX_HUMAN	Isoform Gamma  Cytoplasm. 
# SUBUNIT	BAX_HUMAN	Homodimer. Forms higher oligomers under stress conditions. Interacts with BCL2L11. Interaction with BCL2L11 promotes BAX oligomerization and association with mitochondrial membranes, with subsequent release of cytochrome c. Forms heterodimers with BCL2, E1B 19K protein, BCL2L1 isoform Bcl-X(L), BCL2L2, MCL1 and A1. Interacts with SH3GLB1 and HN. Interacts with SFN and YWHAZ; the interaction occurs in the cytoplasm. Under stress conditions, JNK-mediated phosphorylation of SFN and YWHAZ, releases BAX to mitochondria. Isoform Sigma interacts with BCL2A1 and BCL2L1 isoform Bcl-X(L). Interacts with RNF144B, which regulates the ubiquitin-dependent stability of BAX. Interacts with CLU under stress conditions that cause a conformation change leading to BAX oligomerization and association with mitochondria. Does not interact with CLU in unstressed cells. Interacts with FAIM2/LFG2. Interacts with human cytomegalovirus/HHV-5 protein vMIA/UL37. Interacts with BOP/C22orf29. Interacts (via a C- terminal 33 residues) with NOL3 (via CARD domain); inhibits BAX activation and translocation and consequently cytochrome c release from mitochondria. {ECO 0000269|PubMed 10772918, ECO 0000269|PubMed 11106734, ECO 0000269|PubMed 11259440, ECO 0000269|PubMed 12732850, ECO 0000269|PubMed 15004026, ECO 0000269|PubMed 15004034, ECO 0000269|PubMed 15071501, ECO 0000269|PubMed 16113678, ECO 0000269|PubMed 16946732, ECO 0000269|PubMed 16964429, ECO 0000269|PubMed 18948948, ECO 0000269|PubMed 20300062, ECO 0000269|PubMed 21199865, ECO 0000269|PubMed 23055042, ECO 0000269|PubMed 8358790}. 
# TCDB	1.A.21.1	the bcl-2 (bcl-2) family
# TISSUE SPECIFICITY	BAX_HUMAN	Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro- myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T- cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines. {ECO 0000269|PubMed 10772918, ECO 0000269|PubMed 11912183}. 
# TopDownProteomics	Q07812-1	-. [Q07812-1]
# TopDownProteomics	Q07812-2	-. [Q07812-2]
# TopDownProteomics	Q07812-5	-. [Q07812-5]
# TopDownProteomics	Q07812-6	-. [Q07812-6]
# TopDownProteomics	Q07812-8	-. [Q07812-8]
# UCSC	uc002plf	human. [Q07812-1]
# WEB RESOURCE	BAX_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/BAXID128ch19q13.html";
# WEB RESOURCE	BAX_HUMAN	Name=NIEHS-SNPs; URL="http //egp.gs.washington.edu/data/bax/"; 
# eggNOG	ENOG410IWQJ	Eukaryota
# eggNOG	ENOG4112738	LUCA
BLAST	swissprot:BAX_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:BAX_HUMAN
BioCyc	ZFISH:ENSG00000087088-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000087088-MONOMER
COXPRESdb	581	http://coxpresdb.jp/data/gene/581.shtml
CleanEx	HS_BAX	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_BAX
DIP	DIP-232N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-232N
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/bbrc.1998.0130	http://dx.doi.org/10.1006/bbrc.1998.0130
DOI	10.1006/bbrc.2000.2537	http://dx.doi.org/10.1006/bbrc.2000.2537
DOI	10.1007/s13238-012-2069-7	http://dx.doi.org/10.1007/s13238-012-2069-7
DOI	10.1016/0092-8674(93)90509-O	http://dx.doi.org/10.1016/0092-8674(93)90509-O
DOI	10.1016/0888-7543(95)80180-T	http://dx.doi.org/10.1016/0888-7543(95)80180-T
DOI	10.1016/S0092-8674(00)00167-7	http://dx.doi.org/10.1016/S0092-8674(00)00167-7
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1038/emboj.2010.39	http://dx.doi.org/10.1038/emboj.2010.39
DOI	10.1038/nature01627	http://dx.doi.org/10.1038/nature01627
DOI	10.1038/nature07396	http://dx.doi.org/10.1038/nature07396
DOI	10.1038/ncb1291	http://dx.doi.org/10.1038/ncb1291
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.cdd.4402025	http://dx.doi.org/10.1038/sj.cdd.4402025
DOI	10.1038/sj.emboj.7600194	http://dx.doi.org/10.1038/sj.emboj.7600194
DOI	10.1074/jbc.M101527200	http://dx.doi.org/10.1074/jbc.M101527200
DOI	10.1074/jbc.M110.161281	http://dx.doi.org/10.1074/jbc.M110.161281
DOI	10.1074/jbc.M308408200	http://dx.doi.org/10.1074/jbc.M308408200
DOI	10.1074/jbc.M400695200	http://dx.doi.org/10.1074/jbc.M400695200
DOI	10.1093/emboj/18.9.2330	http://dx.doi.org/10.1093/emboj/18.9.2330
DOI	10.1093/hmg/11.6.675	http://dx.doi.org/10.1093/hmg/11.6.675
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF007826	http://www.ebi.ac.uk/ena/data/view/AF007826
EMBL	AF247393	http://www.ebi.ac.uk/ena/data/view/AF247393
EMBL	AF250190	http://www.ebi.ac.uk/ena/data/view/AF250190
EMBL	AJ417988	http://www.ebi.ac.uk/ena/data/view/AJ417988
EMBL	AK291076	http://www.ebi.ac.uk/ena/data/view/AK291076
EMBL	AY217036	http://www.ebi.ac.uk/ena/data/view/AY217036
EMBL	BC014175	http://www.ebi.ac.uk/ena/data/view/BC014175
EMBL	CH471177	http://www.ebi.ac.uk/ena/data/view/CH471177
EMBL	CH471177	http://www.ebi.ac.uk/ena/data/view/CH471177
EMBL	L22473	http://www.ebi.ac.uk/ena/data/view/L22473
EMBL	L22474	http://www.ebi.ac.uk/ena/data/view/L22474
EMBL	L22475	http://www.ebi.ac.uk/ena/data/view/L22475
EMBL	U19599	http://www.ebi.ac.uk/ena/data/view/U19599
Ensembl	ENST00000293288	http://www.ensembl.org/id/ENST00000293288
Ensembl	ENST00000345358	http://www.ensembl.org/id/ENST00000345358
Ensembl	ENST00000354470	http://www.ensembl.org/id/ENST00000354470
Ensembl	ENST00000356483	http://www.ensembl.org/id/ENST00000356483
Ensembl	ENST00000415969	http://www.ensembl.org/id/ENST00000415969
Ensembl	ENST00000515540	http://www.ensembl.org/id/ENST00000515540
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005741	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005741
GO_component	GO:0005757	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005757
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0046930	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046930
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_component	GO:0097136	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097136
GO_component	GO:0097144	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097144
GO_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GO_function	GO:0015267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015267
GO_function	GO:0042802	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_function	GO:0046982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046982
GO_function	GO:0051434	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051434
GO_process	GO:0001541	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001541
GO_process	GO:0001764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001764
GO_process	GO:0001777	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001777
GO_process	GO:0001782	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001782
GO_process	GO:0001783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001783
GO_process	GO:0001822	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001822
GO_process	GO:0001836	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001836
GO_process	GO:0001844	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001844
GO_process	GO:0001974	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001974
GO_process	GO:0002262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002262
GO_process	GO:0002352	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002352
GO_process	GO:0002358	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002358
GO_process	GO:0002904	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002904
GO_process	GO:0006687	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006687
GO_process	GO:0006808	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006808
GO_process	GO:0006915	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006915
GO_process	GO:0006919	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006919
GO_process	GO:0006977	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006977
GO_process	GO:0006987	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006987
GO_process	GO:0007281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007281
GO_process	GO:0008053	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008053
GO_process	GO:0008625	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008625
GO_process	GO:0008630	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008630
GO_process	GO:0008635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008635
GO_process	GO:0008637	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008637
GO_process	GO:0009566	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009566
GO_process	GO:0009636	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009636
GO_process	GO:0009651	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009651
GO_process	GO:0010248	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010248
GO_process	GO:0010332	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010332
GO_process	GO:0016032	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016032
GO_process	GO:0021854	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021854
GO_process	GO:0021987	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021987
GO_process	GO:0032091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032091
GO_process	GO:0032461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032461
GO_process	GO:0032469	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032469
GO_process	GO:0032471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032471
GO_process	GO:0032976	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032976
GO_process	GO:0033137	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033137
GO_process	GO:0033599	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033599
GO_process	GO:0034644	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034644
GO_process	GO:0035234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035234
GO_process	GO:0042475	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042475
GO_process	GO:0042981	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042981
GO_process	GO:0043065	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043065
GO_process	GO:0043496	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043496
GO_process	GO:0043497	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043497
GO_process	GO:0043524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043524
GO_process	GO:0043525	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043525
GO_process	GO:0043653	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043653
GO_process	GO:0045136	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045136
GO_process	GO:0046666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046666
GO_process	GO:0048087	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048087
GO_process	GO:0048147	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048147
GO_process	GO:0048515	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048515
GO_process	GO:0048597	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048597
GO_process	GO:0048678	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048678
GO_process	GO:0048873	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048873
GO_process	GO:0051259	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051259
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:0051281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051281
GO_process	GO:0051402	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051402
GO_process	GO:0051881	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051881
GO_process	GO:0060011	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060011
GO_process	GO:0060041	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060041
GO_process	GO:0060058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060058
GO_process	GO:0060068	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060068
GO_process	GO:0070059	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070059
GO_process	GO:0070242	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070242
GO_process	GO:0070584	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070584
GO_process	GO:0072332	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072332
GO_process	GO:0090200	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090200
GO_process	GO:0097190	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097190
GO_process	GO:0097191	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097191
GO_process	GO:0097192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097192
GO_process	GO:0097193	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097193
GO_process	GO:0097296	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097296
GO_process	GO:1900103	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900103
GO_process	GO:1901030	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901030
GO_process	GO:1902262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902262
GO_process	GO:1902263	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902263
GO_process	GO:1902445	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902445
GO_process	GO:1902512	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902512
GO_process	GO:1903896	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903896
GO_process	GO:1990117	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990117
GO_process	GO:2001234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001234
GO_process	GO:2001241	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001241
GO_process	GO:2001244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001244
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007005
GOslim_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0008219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219
GOslim_process	GO:0008283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008283
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
GeneCards	BAX	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=BAX
GeneID	581	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=581
GeneTree	ENSGT00730000111112	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00730000111112
HGNC	HGNC:959	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:959
HOVERGEN	HBG003606	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003606&db=HOVERGEN
HPA	CAB004206	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB004206
HPA	HPA027878	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA027878
InParanoid	Q07812	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q07812
IntAct	Q07812	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q07812*
InterPro	IPR002475	http://www.ebi.ac.uk/interpro/entry/IPR002475
InterPro	IPR020717	http://www.ebi.ac.uk/interpro/entry/IPR020717
InterPro	IPR020726	http://www.ebi.ac.uk/interpro/entry/IPR020726
InterPro	IPR020728	http://www.ebi.ac.uk/interpro/entry/IPR020728
InterPro	IPR026298	http://www.ebi.ac.uk/interpro/entry/IPR026298
InterPro	IPR026304	http://www.ebi.ac.uk/interpro/entry/IPR026304
Jabion	581	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=581
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Disease	H00020	http://www.genome.jp/dbget-bin/www_bget?H00020
KEGG_Gene	hsa:581	http://www.genome.jp/dbget-bin/www_bget?hsa:581
KEGG_Orthology	KO:K02159	http://www.genome.jp/dbget-bin/www_bget?KO:K02159
KEGG_Pathway	ko04115	http://www.genome.jp/kegg-bin/show_pathway?ko04115
KEGG_Pathway	ko04141	http://www.genome.jp/kegg-bin/show_pathway?ko04141
KEGG_Pathway	ko04210	http://www.genome.jp/kegg-bin/show_pathway?ko04210
KEGG_Pathway	ko04722	http://www.genome.jp/kegg-bin/show_pathway?ko04722
KEGG_Pathway	ko05014	http://www.genome.jp/kegg-bin/show_pathway?ko05014
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
KEGG_Pathway	ko05020	http://www.genome.jp/kegg-bin/show_pathway?ko05020
KEGG_Pathway	ko05152	http://www.genome.jp/kegg-bin/show_pathway?ko05152
KEGG_Pathway	ko05161	http://www.genome.jp/kegg-bin/show_pathway?ko05161
KEGG_Pathway	ko05166	http://www.genome.jp/kegg-bin/show_pathway?ko05166
KEGG_Pathway	ko05200	http://www.genome.jp/kegg-bin/show_pathway?ko05200
KEGG_Pathway	ko05203	http://www.genome.jp/kegg-bin/show_pathway?ko05203
KEGG_Pathway	ko05210	http://www.genome.jp/kegg-bin/show_pathway?ko05210
MIM	600040	http://www.ncbi.nlm.nih.gov/omim/600040
MINT	MINT-134330	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-134330
OMA	TIINWTI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TIINWTI
OrthoDB	EOG091G0YWR	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0YWR
PANTHER	PTHR11256	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11256
PANTHER	PTHR11256:SF44	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11256:SF44
PDB	1F16	http://www.ebi.ac.uk/pdbe-srv/view/entry/1F16
PDB	2G5B	http://www.ebi.ac.uk/pdbe-srv/view/entry/2G5B
PDB	2K7W	http://www.ebi.ac.uk/pdbe-srv/view/entry/2K7W
PDB	2LR1	http://www.ebi.ac.uk/pdbe-srv/view/entry/2LR1
PDB	3PK1	http://www.ebi.ac.uk/pdbe-srv/view/entry/3PK1
PDB	3PL7	http://www.ebi.ac.uk/pdbe-srv/view/entry/3PL7
PDB	4BD2	http://www.ebi.ac.uk/pdbe-srv/view/entry/4BD2
PDB	4BD6	http://www.ebi.ac.uk/pdbe-srv/view/entry/4BD6
PDB	4BD7	http://www.ebi.ac.uk/pdbe-srv/view/entry/4BD7
PDB	4BD8	http://www.ebi.ac.uk/pdbe-srv/view/entry/4BD8
PDB	4BDU	http://www.ebi.ac.uk/pdbe-srv/view/entry/4BDU
PDB	4S0O	http://www.ebi.ac.uk/pdbe-srv/view/entry/4S0O
PDB	4S0P	http://www.ebi.ac.uk/pdbe-srv/view/entry/4S0P
PDB	4UF2	http://www.ebi.ac.uk/pdbe-srv/view/entry/4UF2
PDB	4ZIE	http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZIE
PDB	4ZIF	http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZIF
PDB	4ZIG	http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZIG
PDB	4ZIH	http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZIH
PDB	4ZII	http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZII
PDBsum	1F16	http://www.ebi.ac.uk/pdbsum/1F16
PDBsum	2G5B	http://www.ebi.ac.uk/pdbsum/2G5B
PDBsum	2K7W	http://www.ebi.ac.uk/pdbsum/2K7W
PDBsum	2LR1	http://www.ebi.ac.uk/pdbsum/2LR1
PDBsum	3PK1	http://www.ebi.ac.uk/pdbsum/3PK1
PDBsum	3PL7	http://www.ebi.ac.uk/pdbsum/3PL7
PDBsum	4BD2	http://www.ebi.ac.uk/pdbsum/4BD2
PDBsum	4BD6	http://www.ebi.ac.uk/pdbsum/4BD6
PDBsum	4BD7	http://www.ebi.ac.uk/pdbsum/4BD7
PDBsum	4BD8	http://www.ebi.ac.uk/pdbsum/4BD8
PDBsum	4BDU	http://www.ebi.ac.uk/pdbsum/4BDU
PDBsum	4S0O	http://www.ebi.ac.uk/pdbsum/4S0O
PDBsum	4S0P	http://www.ebi.ac.uk/pdbsum/4S0P
PDBsum	4UF2	http://www.ebi.ac.uk/pdbsum/4UF2
PDBsum	4ZIE	http://www.ebi.ac.uk/pdbsum/4ZIE
PDBsum	4ZIF	http://www.ebi.ac.uk/pdbsum/4ZIF
PDBsum	4ZIG	http://www.ebi.ac.uk/pdbsum/4ZIG
PDBsum	4ZIH	http://www.ebi.ac.uk/pdbsum/4ZIH
PDBsum	4ZII	http://www.ebi.ac.uk/pdbsum/4ZII
PRINTS	PR01862	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01862
PROSITE	PS01080	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01080
PROSITE	PS01258	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01258
PROSITE	PS01259	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01259
PROSITE	PS50062	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50062
PSORT	swissprot:BAX_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:BAX_HUMAN
PSORT-B	swissprot:BAX_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:BAX_HUMAN
PSORT2	swissprot:BAX_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:BAX_HUMAN
Pfam	PF00452	http://pfam.xfam.org/family/PF00452
PharmGKB	PA25269	http://www.pharmgkb.org/do/serve?objId=PA25269&objCls=Gene
Phobius	swissprot:BAX_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:BAX_HUMAN
PhylomeDB	Q07812	http://phylomedb.org/?seqid=Q07812
ProteinModelPortal	Q07812	http://www.proteinmodelportal.org/query/uniprot/Q07812
PubMed	10228148	http://www.ncbi.nlm.nih.gov/pubmed/10228148
PubMed	10772918	http://www.ncbi.nlm.nih.gov/pubmed/10772918
PubMed	11106734	http://www.ncbi.nlm.nih.gov/pubmed/11106734
PubMed	11259440	http://www.ncbi.nlm.nih.gov/pubmed/11259440
PubMed	11912183	http://www.ncbi.nlm.nih.gov/pubmed/11912183
PubMed	12732850	http://www.ncbi.nlm.nih.gov/pubmed/12732850
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15004026	http://www.ncbi.nlm.nih.gov/pubmed/15004026
PubMed	15004034	http://www.ncbi.nlm.nih.gov/pubmed/15004034
PubMed	15071501	http://www.ncbi.nlm.nih.gov/pubmed/15071501
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16113678	http://www.ncbi.nlm.nih.gov/pubmed/16113678
PubMed	16946732	http://www.ncbi.nlm.nih.gov/pubmed/16946732
PubMed	16964429	http://www.ncbi.nlm.nih.gov/pubmed/16964429
PubMed	18948948	http://www.ncbi.nlm.nih.gov/pubmed/18948948
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	20300062	http://www.ncbi.nlm.nih.gov/pubmed/20300062
PubMed	21199865	http://www.ncbi.nlm.nih.gov/pubmed/21199865
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23055042	http://www.ncbi.nlm.nih.gov/pubmed/23055042
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	7475270	http://www.ncbi.nlm.nih.gov/pubmed/7475270
PubMed	7607685	http://www.ncbi.nlm.nih.gov/pubmed/7607685
PubMed	8358790	http://www.ncbi.nlm.nih.gov/pubmed/8358790
PubMed	8521816	http://www.ncbi.nlm.nih.gov/pubmed/8521816
PubMed	9531611	http://www.ncbi.nlm.nih.gov/pubmed/9531611
PubMed	9920818	http://www.ncbi.nlm.nih.gov/pubmed/9920818
Reactome	R-HSA-114294	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-114294
Reactome	R-HSA-6803204	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6803204
Reactome	R-HSA-6804114	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6804114
RefSeq	NP_001278357	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001278357
RefSeq	NP_001278360	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001278360
RefSeq	NP_004315	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004315
RefSeq	NP_620116	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_620116
RefSeq	NP_620118	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_620118
RefSeq	NP_620119	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_620119
RefSeq	XP_016882566	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016882566
SMR	Q07812	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q07812
STRING	9606.ENSP00000293288	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000293288&targetmode=cogs
TCDB	1.A.21.1	http://www.tcdb.org/search/result.php?tc=1.A.21.1
UCSC	uc002plf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002plf&org=rat
UniGene	Hs.624291	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.624291
UniProtKB	BAX_HUMAN	http://www.uniprot.org/uniprot/BAX_HUMAN
UniProtKB-AC	Q07812	http://www.uniprot.org/uniprot/Q07812
charge	swissprot:BAX_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:BAX_HUMAN
eggNOG	ENOG410IWQJ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IWQJ
eggNOG	ENOG4112738	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4112738
epestfind	swissprot:BAX_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:BAX_HUMAN
garnier	swissprot:BAX_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:BAX_HUMAN
helixturnhelix	swissprot:BAX_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:BAX_HUMAN
hmoment	swissprot:BAX_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:BAX_HUMAN
iep	swissprot:BAX_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:BAX_HUMAN
inforesidue	swissprot:BAX_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:BAX_HUMAN
neXtProt	NX_Q07812	http://www.nextprot.org/db/entry/NX_Q07812
octanol	swissprot:BAX_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:BAX_HUMAN
pepcoil	swissprot:BAX_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:BAX_HUMAN
pepdigest	swissprot:BAX_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:BAX_HUMAN
pepinfo	swissprot:BAX_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:BAX_HUMAN
pepnet	swissprot:BAX_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:BAX_HUMAN
pepstats	swissprot:BAX_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:BAX_HUMAN
pepwheel	swissprot:BAX_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:BAX_HUMAN
pepwindow	swissprot:BAX_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:BAX_HUMAN
sigcleave	swissprot:BAX_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:BAX_HUMAN
## Database	ID	URL or Descriptions
# AltName	CX6B1_HUMAN	Cytochrome c oxidase subunit VIb isoform 1
# BioGrid	107733	48
# CDD	cd00926	Cyt_c_Oxidase_VIb
# ChiTaRS	COX6B1	human
# DISEASE	CX6B1_HUMAN	Mitochondrial complex IV deficiency (MT-C4D) [MIM 220110]  A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, exercise intolerance, developmental delay, delayed motor development and mental retardation. Some affected individuals manifest a fatal hypertrophic cardiomyopathy resulting in neonatal death. A subset of patients manifest Leigh syndrome. {ECO 0000269|PubMed 18499082}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB02659	Cholic Acid
# Ensembl	ENST00000246554	ENSP00000246554; ENSG00000126267
# Ensembl	ENST00000392201	ENSP00000376037; ENSG00000126267
# Ensembl	ENST00000592141	ENSP00000466818; ENSG00000126267
# ExpressionAtlas	P14854	baseline and differential
# FUNCTION	CX6B1_HUMAN	Connects the two COX monomers into the physiological dimeric form. {ECO 0000250}. 
# GO_component	GO:0005739	mitochondrion; IDA:HPA.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0005758	mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
# GO_function	GO:0004129	cytochrome-c oxidase activity; NAS:UniProtKB.
# GO_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen; TAS:Reactome.
# GO_process	GO:0021762	substantia nigra development; IEP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# GOslim_process	GO:0048856	anatomical structure development
# Gene3D	1.10.10.140	-; 1.
# Genevisible	P14854	HS
# HGNC	HGNC:2280	COX6B1
# IntAct	P14854	19
# InterPro	IPR003213	Cyt_c_oxidase_su6B
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Disease	H01368:[Inherited metabolic disease; Mitochondrial disease] Leber Hereditary Optic Neuropathy (LHON) [DS	H00068]
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	124089	gene
# MIM	220110	phenotype
# Organism	CX6B1_HUMAN	Homo sapiens (Human)
# Orphanet	254905	Isolated cytochrome C oxidase deficiency
# Orphanet	70474	Leigh syndrome with cardiomyopathy
# PIR	S03287	OGHU6B
# PIRSF	PIRSF000278	Cyt_c_oxidase_6B
# PROSITE	PS51808	CHCH
# Pfam	PF02297	COX6B
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-5628897	TP53 Regulates Metabolic Genes
# Reactome	R-HSA-611105	Respiratory electron transport
# RecName	CX6B1_HUMAN	Cytochrome c oxidase subunit 6B1
# RefSeq	NP_001854	NM_001863.4
# SIMILARITY	Belongs to the cytochrome c oxidase subunit 6B family. {ECO	0000305}. 
# SIMILARITY	Contains 1 CHCH (coiled coil-helix-coiled coil-helix) domain. {ECO:0000255|PROSITE-ProRule	PRU01150}.
# SUBCELLULAR LOCATION	CX6B1_HUMAN	Mitochondrion intermembrane space {ECO 0000250}. 
# SUPFAM	SSF47694	SSF47694
# UCSC	uc002oav	human
# eggNOG	ENOG41121WM	LUCA
# eggNOG	KOG3057	Eukaryota
BLAST	swissprot:CX6B1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CX6B1_HUMAN
BioCyc	ZFISH:HS05010-MONOMER	http://biocyc.org/getid?id=ZFISH:HS05010-MONOMER
COXPRESdb	1340	http://coxpresdb.jp/data/gene/1340.shtml
CleanEx	HS_COX6B1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_COX6B1
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/0167-4781(91)90027-J	http://dx.doi.org/10.1016/0167-4781(91)90027-J
DOI	10.1016/0378-1119(90)90237-L	http://dx.doi.org/10.1016/0378-1119(90)90237-L
DOI	10.1016/0378-1119(91)90082-M	http://dx.doi.org/10.1016/0378-1119(91)90082-M
DOI	10.1016/j.ajhg.2008.05.002	http://dx.doi.org/10.1016/j.ajhg.2008.05.002
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1093/nar/17.4.1766	http://dx.doi.org/10.1093/nar/17.4.1766
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DrugBank	DB02659	http://www.drugbank.ca/drugs/DB02659
EMBL	AC002115	http://www.ebi.ac.uk/ena/data/view/AC002115
EMBL	AK312140	http://www.ebi.ac.uk/ena/data/view/AK312140
EMBL	BC001015	http://www.ebi.ac.uk/ena/data/view/BC001015
EMBL	BC002478	http://www.ebi.ac.uk/ena/data/view/BC002478
EMBL	BT006945	http://www.ebi.ac.uk/ena/data/view/BT006945
EMBL	CR456789	http://www.ebi.ac.uk/ena/data/view/CR456789
EMBL	CR542137	http://www.ebi.ac.uk/ena/data/view/CR542137
EMBL	X13923	http://www.ebi.ac.uk/ena/data/view/X13923
EMBL	X54473	http://www.ebi.ac.uk/ena/data/view/X54473
EMBL	X58139	http://www.ebi.ac.uk/ena/data/view/X58139
Ensembl	ENST00000246554	http://www.ensembl.org/id/ENST00000246554
Ensembl	ENST00000392201	http://www.ensembl.org/id/ENST00000392201
Ensembl	ENST00000592141	http://www.ensembl.org/id/ENST00000592141
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005758	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005758
GO_function	GO:0004129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004129
GO_process	GO:0006123	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006123
GO_process	GO:0021762	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021762
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
Gene3D	1.10.10.140	http://www.cathdb.info/version/latest/superfamily/1.10.10.140
GeneCards	COX6B1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=COX6B1
GeneID	1340	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1340
GeneTree	ENSGT00390000001191	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000001191
HGNC	HGNC:2280	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2280
HOGENOM	HOG000165128	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000165128&db=HOGENOM6
HOVERGEN	HBG051090	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051090&db=HOVERGEN
HPA	HPA004192	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA004192
InParanoid	P14854	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P14854
IntAct	P14854	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P14854*
InterPro	IPR003213	http://www.ebi.ac.uk/interpro/entry/IPR003213
Jabion	1340	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1340
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Disease	H01368	http://www.genome.jp/dbget-bin/www_bget?H01368
KEGG_Gene	hsa:1340	http://www.genome.jp/dbget-bin/www_bget?hsa:1340
KEGG_Orthology	KO:K02267	http://www.genome.jp/dbget-bin/www_bget?KO:K02267
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	124089	http://www.ncbi.nlm.nih.gov/omim/124089
MIM	220110	http://www.ncbi.nlm.nih.gov/omim/220110
MINT	MINT-3008230	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3008230
OMA	LDFHRCQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LDFHRCQ
Orphanet	254905	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=254905
Orphanet	70474	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=70474
OrthoDB	EOG091G0UIB	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0UIB
PROSITE	PS51808	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51808
PSORT	swissprot:CX6B1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CX6B1_HUMAN
PSORT-B	swissprot:CX6B1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CX6B1_HUMAN
PSORT2	swissprot:CX6B1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CX6B1_HUMAN
Pfam	PF02297	http://pfam.xfam.org/family/PF02297
PharmGKB	PA26797	http://www.pharmgkb.org/do/serve?objId=PA26797&objCls=Gene
Phobius	swissprot:CX6B1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CX6B1_HUMAN
PhylomeDB	P14854	http://phylomedb.org/?seqid=P14854
ProteinModelPortal	P14854	http://www.proteinmodelportal.org/query/uniprot/P14854
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	1647217	http://www.ncbi.nlm.nih.gov/pubmed/1647217
PubMed	1651883	http://www.ncbi.nlm.nih.gov/pubmed/1651883
PubMed	18499082	http://www.ncbi.nlm.nih.gov/pubmed/18499082
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	2172092	http://www.ncbi.nlm.nih.gov/pubmed/2172092
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	2537962	http://www.ncbi.nlm.nih.gov/pubmed/2537962
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-5628897	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5628897
Reactome	R-HSA-611105	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-611105
RefSeq	NP_001854	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001854
SMR	P14854	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P14854
STRING	9606.ENSP00000246554	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000246554&targetmode=cogs
SUPFAM	SSF47694	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47694
UCSC	uc002oav	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002oav&org=rat
UniGene	Hs.431668	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.431668
UniProtKB	CX6B1_HUMAN	http://www.uniprot.org/uniprot/CX6B1_HUMAN
UniProtKB-AC	P14854	http://www.uniprot.org/uniprot/P14854
charge	swissprot:CX6B1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CX6B1_HUMAN
eggNOG	ENOG41121WM	http://eggnogapi.embl.de/nog_data/html/tree/ENOG41121WM
eggNOG	KOG3057	http://eggnogapi.embl.de/nog_data/html/tree/KOG3057
epestfind	swissprot:CX6B1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CX6B1_HUMAN
garnier	swissprot:CX6B1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CX6B1_HUMAN
helixturnhelix	swissprot:CX6B1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CX6B1_HUMAN
hmoment	swissprot:CX6B1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CX6B1_HUMAN
iep	swissprot:CX6B1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CX6B1_HUMAN
inforesidue	swissprot:CX6B1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CX6B1_HUMAN
neXtProt	NX_P14854	http://www.nextprot.org/db/entry/NX_P14854
octanol	swissprot:CX6B1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CX6B1_HUMAN
pepcoil	swissprot:CX6B1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CX6B1_HUMAN
pepdigest	swissprot:CX6B1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CX6B1_HUMAN
pepinfo	swissprot:CX6B1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CX6B1_HUMAN
pepnet	swissprot:CX6B1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CX6B1_HUMAN
pepstats	swissprot:CX6B1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CX6B1_HUMAN
pepwheel	swissprot:CX6B1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CX6B1_HUMAN
pepwindow	swissprot:CX6B1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CX6B1_HUMAN
sigcleave	swissprot:CX6B1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CX6B1_HUMAN
## Database	ID	URL or Descriptions
# AltName	AQP9_HUMAN	Aquaglyceroporin-9
# AltName	AQP9_HUMAN	Small solute channel 1
# BioGrid	106861	3
# CDD	cd00333	MIP
# DOMAIN	AQP9_HUMAN	Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). 
# Ensembl	ENST00000219919	ENSP00000219919; ENSG00000103569
# Ensembl	ENST00000536493	ENSP00000441390; ENSG00000103569
# ExpressionAtlas	O43315	baseline and differential
# FUNCTION	AQP9_HUMAN	Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol. {ECO 0000269|PubMed 10564231}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:Ensembl.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:UniProtKB.
# GO_function	GO:0005275	amine transmembrane transporter activity; TAS:UniProtKB.
# GO_function	GO:0005345	purine nucleobase transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0005350	pyrimidine nucleobase transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0005372	water transmembrane transporter activity; TAS:UniProtKB.
# GO_function	GO:0015166	polyol transmembrane transporter activity; TAS:UniProtKB.
# GO_function	GO:0015204	urea transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015250	water channel activity; IDA:UniProtKB.
# GO_function	GO:0015254	glycerol channel activity; EXP:Reactome.
# GO_function	GO:0015265	urea channel activity; EXP:Reactome.
# GO_function	GO:0015288	porin activity; NAS:UniProtKB.
# GO_function	GO:0046943	carboxylic acid transmembrane transporter activity; TAS:UniProtKB.
# GO_process	GO:0006810	transport; TAS:UniProtKB.
# GO_process	GO:0006833	water transport; IDA:UniProtKB.
# GO_process	GO:0006863	purine nucleobase transport; IDA:UniProtKB.
# GO_process	GO:0006955	immune response; TAS:ProtInc.
# GO_process	GO:0006970	response to osmotic stress; TAS:UniProtKB.
# GO_process	GO:0007588	excretion; TAS:UniProtKB.
# GO_process	GO:0008152	metabolic process; TAS:UniProtKB.
# GO_process	GO:0009992	cellular water homeostasis; IBA:GO_Central.
# GO_process	GO:0010033	response to organic substance; IDA:UniProtKB.
# GO_process	GO:0015722	canalicular bile acid transport; IEA:Ensembl.
# GO_process	GO:0015791	polyol transport; IDA:UniProtKB.
# GO_process	GO:0015793	glycerol transport; TAS:Reactome.
# GO_process	GO:0015837	amine transport; IDA:UniProtKB.
# GO_process	GO:0015855	pyrimidine nucleobase transport; IDA:UniProtKB.
# GO_process	GO:0030104	water homeostasis; NAS:UniProtKB.
# GO_process	GO:0046689	response to mercury ion; IDA:UniProtKB.
# GO_process	GO:0046942	carboxylic acid transport; TAS:UniProtKB.
# GO_process	GO:0071320	cellular response to cAMP; IEP:UniProtKB.
# GO_process	GO:0071918	urea transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.1080.10	-; 1.
# Genevisible	O43315	HS
# HGNC	HGNC:643	AQP9
# InterPro	IPR000425	MIP
# InterPro	IPR015685	Aquaporin_9
# InterPro	IPR022357	MIP_CS
# InterPro	IPR023271	Aquaporin-like
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04976	Bile secretion
# MIM	602914	gene+phenotype
# Organism	AQP9_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR19139	PTHR19139
# PIR	JC5973	JC5973
# PRINTS	PR00783	MINTRINSICP
# PRINTS	PR02021	AQUAPORIN9
# PROSITE	PS00221	MIP
# Pfam	PF00230	MIP
# Proteomes	UP000005640	Chromosome 15
# Reactome	R-HSA-432030	Transport of glycerol from adipocytes to the liver by Aquaporins
# Reactome	R-HSA-432047	Passive transport by Aquaporins
# RecName	AQP9_HUMAN	Aquaporin-9
# RefSeq	NP_066190	NM_020980.4
# SIMILARITY	Belongs to the MIP/aquaporin (TC 1.A.8) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	AQP9_HUMAN	Membrane; Multi-pass membrane protein. 
# SUPFAM	SSF81338	SSF81338
# TIGRFAMs	TIGR00861	MIP
# TISSUE SPECIFICITY	AQP9_HUMAN	Highly expressed in peripheral leukocytes. Also expressed in liver, lung, and spleen. 
# UCSC	uc002aez	human
# eggNOG	COG0580	LUCA
# eggNOG	KOG0224	Eukaryota
BLAST	swissprot:AQP9_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AQP9_HUMAN
BioCyc	ZFISH:ENSG00000103569-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000103569-MONOMER
COXPRESdb	366	http://coxpresdb.jp/data/gene/366.shtml
CleanEx	HS_AQP9	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AQP9
DOI	10.1006/bbrc.1998.8252	http://dx.doi.org/10.1006/bbrc.1998.8252
DOI	10.1038/nature04601	http://dx.doi.org/10.1038/nature04601
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB008775	http://www.ebi.ac.uk/ena/data/view/AB008775
EMBL	AC025431	http://www.ebi.ac.uk/ena/data/view/AC025431
EMBL	AC066616	http://www.ebi.ac.uk/ena/data/view/AC066616
EMBL	AF016495	http://www.ebi.ac.uk/ena/data/view/AF016495
EMBL	AF102870	http://www.ebi.ac.uk/ena/data/view/AF102870
EMBL	BC026258	http://www.ebi.ac.uk/ena/data/view/BC026258
Ensembl	ENST00000219919	http://www.ensembl.org/id/ENST00000219919
Ensembl	ENST00000536493	http://www.ensembl.org/id/ENST00000536493
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0005275	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005275
GO_function	GO:0005345	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005345
GO_function	GO:0005350	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005350
GO_function	GO:0005372	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005372
GO_function	GO:0015166	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015166
GO_function	GO:0015204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015204
GO_function	GO:0015250	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015250
GO_function	GO:0015254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015254
GO_function	GO:0015265	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015265
GO_function	GO:0015288	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015288
GO_function	GO:0046943	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046943
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006833	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006833
GO_process	GO:0006863	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006863
GO_process	GO:0006955	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006955
GO_process	GO:0006970	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006970
GO_process	GO:0007588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007588
GO_process	GO:0008152	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008152
GO_process	GO:0009992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009992
GO_process	GO:0010033	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010033
GO_process	GO:0015722	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015722
GO_process	GO:0015791	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015791
GO_process	GO:0015793	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015793
GO_process	GO:0015837	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015837
GO_process	GO:0015855	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015855
GO_process	GO:0030104	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030104
GO_process	GO:0046689	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046689
GO_process	GO:0046942	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046942
GO_process	GO:0071320	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071320
GO_process	GO:0071918	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071918
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.1080.10	http://www.cathdb.info/version/latest/superfamily/1.20.1080.10
GeneCards	AQP9	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=AQP9
GeneID	366	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=366
GeneTree	ENSGT00510000046311	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00510000046311
H-InvDB	HIX0012281	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0012281
HGNC	HGNC:643	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:643
HOGENOM	HOG000288287	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000288287&db=HOGENOM6
HOVERGEN	HBG106057	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG106057&db=HOVERGEN
InParanoid	O43315	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O43315
InterPro	IPR000425	http://www.ebi.ac.uk/interpro/entry/IPR000425
InterPro	IPR015685	http://www.ebi.ac.uk/interpro/entry/IPR015685
InterPro	IPR022357	http://www.ebi.ac.uk/interpro/entry/IPR022357
InterPro	IPR023271	http://www.ebi.ac.uk/interpro/entry/IPR023271
Jabion	366	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=366
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:366	http://www.genome.jp/dbget-bin/www_bget?hsa:366
KEGG_Orthology	KO:K09877	http://www.genome.jp/dbget-bin/www_bget?KO:K09877
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
MIM	602914	http://www.ncbi.nlm.nih.gov/omim/602914
OMA	WNETKDA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WNETKDA
OrthoDB	EOG091G0FMS	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0FMS
PANTHER	PTHR19139	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19139
PRINTS	PR00783	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00783
PRINTS	PR02021	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR02021
PROSITE	PS00221	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00221
PSORT	swissprot:AQP9_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AQP9_HUMAN
PSORT-B	swissprot:AQP9_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AQP9_HUMAN
PSORT2	swissprot:AQP9_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AQP9_HUMAN
Pfam	PF00230	http://pfam.xfam.org/family/PF00230
PharmGKB	PA24927	http://www.pharmgkb.org/do/serve?objId=PA24927&objCls=Gene
Phobius	swissprot:AQP9_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AQP9_HUMAN
PhylomeDB	O43315	http://phylomedb.org/?seqid=O43315
ProteinModelPortal	O43315	http://www.proteinmodelportal.org/query/uniprot/O43315
PubMed	10564231	http://www.ncbi.nlm.nih.gov/pubmed/10564231
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16572171	http://www.ncbi.nlm.nih.gov/pubmed/16572171
PubMed	9514918	http://www.ncbi.nlm.nih.gov/pubmed/9514918
Reactome	R-HSA-432030	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432030
Reactome	R-HSA-432047	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432047
RefSeq	NP_066190	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_066190
SMR	O43315	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O43315
STRING	9606.ENSP00000219919	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000219919&targetmode=cogs
SUPFAM	SSF81338	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81338
TIGRFAMs	TIGR00861	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00861
UCSC	uc002aez	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002aez&org=rat
UniGene	Hs.104624	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.104624
UniProtKB	AQP9_HUMAN	http://www.uniprot.org/uniprot/AQP9_HUMAN
UniProtKB-AC	O43315	http://www.uniprot.org/uniprot/O43315
charge	swissprot:AQP9_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AQP9_HUMAN
eggNOG	COG0580	http://eggnogapi.embl.de/nog_data/html/tree/COG0580
eggNOG	KOG0224	http://eggnogapi.embl.de/nog_data/html/tree/KOG0224
epestfind	swissprot:AQP9_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AQP9_HUMAN
garnier	swissprot:AQP9_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AQP9_HUMAN
helixturnhelix	swissprot:AQP9_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AQP9_HUMAN
hmoment	swissprot:AQP9_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AQP9_HUMAN
iep	swissprot:AQP9_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AQP9_HUMAN
inforesidue	swissprot:AQP9_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AQP9_HUMAN
neXtProt	NX_O43315	http://www.nextprot.org/db/entry/NX_O43315
octanol	swissprot:AQP9_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AQP9_HUMAN
pepcoil	swissprot:AQP9_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AQP9_HUMAN
pepdigest	swissprot:AQP9_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AQP9_HUMAN
pepinfo	swissprot:AQP9_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AQP9_HUMAN
pepnet	swissprot:AQP9_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AQP9_HUMAN
pepstats	swissprot:AQP9_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AQP9_HUMAN
pepwheel	swissprot:AQP9_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AQP9_HUMAN
pepwindow	swissprot:AQP9_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AQP9_HUMAN
sigcleave	swissprot:AQP9_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AQP9_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	RYR3_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q15413-1; Sequence=Displayed; Name=2; IsoId=Q15413-2; Sequence=VSP_005954; Name=3; IsoId=Q15413-3; Sequence=VSP_005955, VSP_005956; 
# AltName	RYR3_HUMAN	Brain ryanodine receptor-calcium release channel
# AltName	RYR3_HUMAN	Brain-type ryanodine receptor
# AltName	RYR3_HUMAN	Type 3 ryanodine receptor
# BioGrid	112175	6
# CCDS	CCDS45210	-. [Q15413-1]
# CCDS	CCDS58351	-. [Q15413-2]
# ChiTaRS	RYR3	human
# DOMAIN	RYR3_HUMAN	The calcium release channel activity resides in the C- terminal region while the remaining part of the protein resides in the cytoplasm. {ECO 0000305}. 
# Ensembl	ENST00000415757	ENSP00000399610; ENSG00000198838. [Q15413-2]
# Ensembl	ENST00000634891	ENSP00000489262; ENSG00000198838. [Q15413-1]
# ExpressionAtlas	Q15413	baseline and differential
# FUNCTION	RYR3_HUMAN	Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Contributes to cellular calcium ion homeostasis (By similarity). Plays a role in cellular calcium signaling. {ECO 0000250, ECO 0000269|PubMed 12354756}. 
# GO_component	GO:0005790	smooth endoplasmic reticulum; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; ISS:UniProtKB.
# GO_component	GO:0016529	sarcoplasmic reticulum; ISS:UniProtKB.
# GO_component	GO:0030018	Z disc; IBA:GO_Central.
# GO_component	GO:0033017	sarcoplasmic reticulum membrane; ISS:UniProtKB.
# GO_component	GO:0034704	calcium channel complex; IBA:GO_Central.
# GO_component	GO:0042383	sarcolemma; IBA:GO_Central.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IEA:Ensembl.
# GO_function	GO:0005219	ryanodine-sensitive calcium-release channel activity; ISS:UniProtKB.
# GO_function	GO:0005509	calcium ion binding; IBA:GO_Central.
# GO_function	GO:0015278	calcium-release channel activity; IMP:UniProtKB.
# GO_function	GO:0048763	calcium-induced calcium release activity; IBA:GO_Central.
# GO_process	GO:0006816	calcium ion transport; IMP:UniProtKB.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0051289	protein homotetramerization; ISS:UniProtKB.
# GO_process	GO:0051481	negative regulation of cytosolic calcium ion concentration; IEA:Ensembl.
# GO_process	GO:0070588	calcium ion transmembrane transport; ISS:UniProtKB.
# GO_process	GO:0071277	cellular response to calcium ion; ISS:UniProtKB.
# GO_process	GO:0071286	cellular response to magnesium ion; ISS:UniProtKB.
# GO_process	GO:0071313	cellular response to caffeine; ISS:UniProtKB.
# GO_process	GO:0071318	cellular response to ATP; ISS:UniProtKB.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.10.238.10	-; 1.
# Gene3D	1.25.10.30	-; 1.
# Genevisible	Q15413	HS
# HGNC	HGNC:10485	RYR3
# IntAct	Q15413	2
# InterPro	IPR000699	RIH_dom
# InterPro	IPR001870	B30.2/SPRY
# InterPro	IPR002048	EF_hand_dom
# InterPro	IPR003032	Ryanodine_rcpt
# InterPro	IPR003877	SPRY_dom
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR009460	Ryanrecept_TM4-6
# InterPro	IPR011992	EF-hand-dom_pair
# InterPro	IPR013320	ConA-like_dom
# InterPro	IPR013333	Ryan_recept
# InterPro	IPR013662	RIH_assoc-dom
# InterPro	IPR014821	Ins145_P3_rcpt
# InterPro	IPR015925	Ryanodine_recept-rel
# InterPro	IPR016024	ARM-type_fold
# InterPro	IPR016093	MIR_motif
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04713	Circadian entrainment
# KEGG_Pathway	ko04970	Salivary secretion
# KEGG_Pathway	ko05010	Alzheimer's disease
# MIM	180903	gene
# MISCELLANEOUS	Channel activity is modulated by the alkaloid ryanodine that binds to the open calcium-release channel with high affinity. At low concentrations, ryanodine maintains the channel in an open conformation. High ryanodine concentrations inhibit channel activity. Channel activity is regulated by calmodulin (CALM). The calcium release is activated by elevated cytoplasmic calcium levels in the micromolar range, by caffeine and adenine nucleotides, such as AMP and ATP. Inhibited by Mg(2+) and ruthenium red (By similarity). {ECO	0000250}. 
# Organism	RYR3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR13715	PTHR13715; 6
# PDB	4ERV	X-ray; 1.75 A; A=2597-2800
# PIR	S37537	S37537
# PIR	S66631	S66631
# PRINTS	PR00795	RYANODINER
# PROSITE	PS50188	B302_SPRY; 3
# PROSITE	PS50919	MIR; 5
# Pfam	PF00520	Ion_trans
# Pfam	PF00622	SPRY; 3
# Pfam	PF01365	RYDR_ITPR; 2
# Pfam	PF02026	RyR; 4
# Pfam	PF02815	MIR
# Pfam	PF06459	RR_TM4-6
# Pfam	PF08454	RIH_assoc
# Pfam	PF08709	Ins145_P3_rec
# Proteomes	UP000005640	Chromosome 15
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# Reactome	R-HSA-5578775	Ion homeostasis
# RecName	RYR3_HUMAN	Ryanodine receptor 3
# RefSeq	NP_001027	NM_001036.4. [Q15413-1]
# RefSeq	NP_001230925	NM_001243996.2. [Q15413-2]
# SEQUENCE CAUTION	Sequence=BAA23795.1; Type=Frameshift; Positions=742, 766; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR3 subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 3 B30.2/SPRY domains. {ECO:0000255|PROSITE- ProRule	PRU00548}. 
# SIMILARITY	Contains 5 MIR domains. {ECO:0000255|PROSITE- ProRule	PRU00131}. 
# SMART	SM00449	SPRY; 3
# SMART	SM00472	MIR; 4
# SUBCELLULAR LOCATION	RYR3_HUMAN	Sarcoplasmic reticulum membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. Microsome membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Sarcoplasmic reticulum {ECO 0000250|UniProtKB Q9TS33}. Note=The number of predicted transmembrane domains varies between orthologs, but both N- terminus and C-terminus seem to be cytoplasmic. {ECO 0000250}. 
# SUBUNIT	RYR3_HUMAN	Homotetramer. Heterotetramer with RYR2. Interacts with CALM (By similarity). Interacts with FKBP1A. Interacts with SEPN1 (By similarity). {ECO 0000250|UniProtKB Q9TS33, ECO 0000269|PubMed 22100703}. 
# SUPFAM	SSF100909	SSF100909
# SUPFAM	SSF47473	SSF47473
# SUPFAM	SSF48371	SSF48371; 10
# SUPFAM	SSF49899	SSF49899; 3
# SUPFAM	SSF82109	SSF82109; 2
# TISSUE SPECIFICITY	RYR3_HUMAN	Brain, skeletal muscle, placenta and possibly liver and kidney. In brain, highest levels are found in the cerebellum, hippocampus, caudate nucleus and amygdala, with lower levels in the corpus callosum, substantia nigra and thalamus. {ECO 0000269|PubMed 9395096, ECO 0000269|PubMed 9607712}. 
# UCSC	uc001zhi	human. [Q15413-1]
# WEB RESOURCE	RYR3_HUMAN	Name=Wikipedia; Note=Ryanodine receptor entry; URL="https //en.wikipedia.org/wiki/Ryanodine_receptor";
# eggNOG	ENOG410YCNW	LUCA
# eggNOG	KOG2243	Eukaryota
BLAST	swissprot:RYR3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:RYR3_HUMAN
BioCyc	ZFISH:G66-31928-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31928-MONOMER
COXPRESdb	6263	http://coxpresdb.jp/data/gene/6263.shtml
CleanEx	HS_RYR3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_RYR3
DOI	10.1006/geno.1993.1446	http://dx.doi.org/10.1006/geno.1993.1446
DOI	10.1016/0014-5793(94)00955-4	http://dx.doi.org/10.1016/0014-5793(94)00955-4
DOI	10.1016/0014-5793(95)00924-X	http://dx.doi.org/10.1016/0014-5793(95)00924-X
DOI	10.1016/S0014-5793(97)01275-1	http://dx.doi.org/10.1016/S0014-5793(97)01275-1
DOI	10.1016/S0014-5793(98)00124-0	http://dx.doi.org/10.1016/S0014-5793(98)00124-0
DOI	10.1016/S0306-4522(97)00612-X	http://dx.doi.org/10.1016/S0306-4522(97)00612-X
DOI	10.1016/j.abb.2011.11.004	http://dx.doi.org/10.1016/j.abb.2011.11.004
DOI	10.1038/nature04601	http://dx.doi.org/10.1038/nature04601
DOI	10.1074/jbc.M209061200	http://dx.doi.org/10.1074/jbc.M209061200
EMBL	AB001025	http://www.ebi.ac.uk/ena/data/view/AB001025
EMBL	AC010809	http://www.ebi.ac.uk/ena/data/view/AC010809
EMBL	AC011938	http://www.ebi.ac.uk/ena/data/view/AC011938
EMBL	AC055874	http://www.ebi.ac.uk/ena/data/view/AC055874
EMBL	AC067793	http://www.ebi.ac.uk/ena/data/view/AC067793
EMBL	AC087638	http://www.ebi.ac.uk/ena/data/view/AC087638
EMBL	AJ001515	http://www.ebi.ac.uk/ena/data/view/AJ001515
EMBL	AJ002512	http://www.ebi.ac.uk/ena/data/view/AJ002512
EMBL	X74269	http://www.ebi.ac.uk/ena/data/view/X74269
EMBL	X74270	http://www.ebi.ac.uk/ena/data/view/X74270
Ensembl	ENST00000415757	http://www.ensembl.org/id/ENST00000415757
Ensembl	ENST00000634891	http://www.ensembl.org/id/ENST00000634891
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005790
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016529	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016529
GO_component	GO:0030018	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030018
GO_component	GO:0033017	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033017
GO_component	GO:0034704	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034704
GO_component	GO:0042383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042383
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_function	GO:0005219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005219
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0015278	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015278
GO_function	GO:0048763	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048763
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0051289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051289
GO_process	GO:0051481	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051481
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:0071277	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071277
GO_process	GO:0071286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071286
GO_process	GO:0071313	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071313
GO_process	GO:0071318	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071318
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.10.238.10	http://www.cathdb.info/version/latest/superfamily/1.10.238.10
Gene3D	1.25.10.30	http://www.cathdb.info/version/latest/superfamily/1.25.10.30
GeneCards	RYR3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=RYR3
GeneID	6263	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6263
GeneTree	ENSGT00760000119152	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119152
H-InvDB	HIX0038065	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0038065
HGNC	HGNC:10485	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10485
HOGENOM	HOG000231428	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231428&db=HOGENOM6
HOVERGEN	HBG006699	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006699&db=HOVERGEN
HPA	CAB006887	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB006887
InParanoid	Q15413	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q15413
IntAct	Q15413	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q15413*
InterPro	IPR000699	http://www.ebi.ac.uk/interpro/entry/IPR000699
InterPro	IPR001870	http://www.ebi.ac.uk/interpro/entry/IPR001870
InterPro	IPR002048	http://www.ebi.ac.uk/interpro/entry/IPR002048
InterPro	IPR003032	http://www.ebi.ac.uk/interpro/entry/IPR003032
InterPro	IPR003877	http://www.ebi.ac.uk/interpro/entry/IPR003877
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR009460	http://www.ebi.ac.uk/interpro/entry/IPR009460
InterPro	IPR011992	http://www.ebi.ac.uk/interpro/entry/IPR011992
InterPro	IPR013320	http://www.ebi.ac.uk/interpro/entry/IPR013320
InterPro	IPR013333	http://www.ebi.ac.uk/interpro/entry/IPR013333
InterPro	IPR013662	http://www.ebi.ac.uk/interpro/entry/IPR013662
InterPro	IPR014821	http://www.ebi.ac.uk/interpro/entry/IPR014821
InterPro	IPR015925	http://www.ebi.ac.uk/interpro/entry/IPR015925
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
InterPro	IPR016093	http://www.ebi.ac.uk/interpro/entry/IPR016093
Jabion	6263	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6263
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:6263	http://www.genome.jp/dbget-bin/www_bget?hsa:6263
KEGG_Orthology	KO:K04963	http://www.genome.jp/dbget-bin/www_bget?KO:K04963
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04713	http://www.genome.jp/kegg-bin/show_pathway?ko04713
KEGG_Pathway	ko04970	http://www.genome.jp/kegg-bin/show_pathway?ko04970
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
MIM	180903	http://www.ncbi.nlm.nih.gov/omim/180903
PANTHER	PTHR13715	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13715
PDB	4ERV	http://www.ebi.ac.uk/pdbe-srv/view/entry/4ERV
PDBsum	4ERV	http://www.ebi.ac.uk/pdbsum/4ERV
PRINTS	PR00795	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00795
PROSITE	PS50188	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50188
PROSITE	PS50919	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50919
PSORT	swissprot:RYR3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:RYR3_HUMAN
PSORT-B	swissprot:RYR3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:RYR3_HUMAN
PSORT2	swissprot:RYR3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:RYR3_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF00622	http://pfam.xfam.org/family/PF00622
Pfam	PF01365	http://pfam.xfam.org/family/PF01365
Pfam	PF02026	http://pfam.xfam.org/family/PF02026
Pfam	PF02815	http://pfam.xfam.org/family/PF02815
Pfam	PF06459	http://pfam.xfam.org/family/PF06459
Pfam	PF08454	http://pfam.xfam.org/family/PF08454
Pfam	PF08709	http://pfam.xfam.org/family/PF08709
PharmGKB	PA34897	http://www.pharmgkb.org/do/serve?objId=PA34897&objCls=Gene
Phobius	swissprot:RYR3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:RYR3_HUMAN
PhylomeDB	Q15413	http://phylomedb.org/?seqid=Q15413
ProteinModelPortal	Q15413	http://www.proteinmodelportal.org/query/uniprot/Q15413
PubMed	12354756	http://www.ncbi.nlm.nih.gov/pubmed/12354756
PubMed	16572171	http://www.ncbi.nlm.nih.gov/pubmed/16572171
PubMed	22100703	http://www.ncbi.nlm.nih.gov/pubmed/22100703
PubMed	7523185	http://www.ncbi.nlm.nih.gov/pubmed/7523185
PubMed	7556644	http://www.ncbi.nlm.nih.gov/pubmed/7556644
PubMed	8276408	http://www.ncbi.nlm.nih.gov/pubmed/8276408
PubMed	9395096	http://www.ncbi.nlm.nih.gov/pubmed/9395096
PubMed	9515741	http://www.ncbi.nlm.nih.gov/pubmed/9515741
PubMed	9607712	http://www.ncbi.nlm.nih.gov/pubmed/9607712
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
RefSeq	NP_001027	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001027
RefSeq	NP_001230925	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001230925
SMART	SM00449	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00449
SMART	SM00472	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00472
SMR	Q15413	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q15413
STRING	9606.ENSP00000373884	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000373884&targetmode=cogs
SUPFAM	SSF100909	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF100909
SUPFAM	SSF47473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47473
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
SUPFAM	SSF49899	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49899
SUPFAM	SSF82109	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82109
UCSC	uc001zhi	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001zhi&org=rat
UniGene	Hs.709373	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.709373
UniProtKB	RYR3_HUMAN	http://www.uniprot.org/uniprot/RYR3_HUMAN
UniProtKB-AC	Q15413	http://www.uniprot.org/uniprot/Q15413
charge	swissprot:RYR3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:RYR3_HUMAN
eggNOG	ENOG410YCNW	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YCNW
eggNOG	KOG2243	http://eggnogapi.embl.de/nog_data/html/tree/KOG2243
epestfind	swissprot:RYR3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:RYR3_HUMAN
garnier	swissprot:RYR3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:RYR3_HUMAN
helixturnhelix	swissprot:RYR3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:RYR3_HUMAN
hmoment	swissprot:RYR3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:RYR3_HUMAN
iep	swissprot:RYR3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:RYR3_HUMAN
inforesidue	swissprot:RYR3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:RYR3_HUMAN
neXtProt	NX_Q15413	http://www.nextprot.org/db/entry/NX_Q15413
octanol	swissprot:RYR3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:RYR3_HUMAN
pepcoil	swissprot:RYR3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:RYR3_HUMAN
pepdigest	swissprot:RYR3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:RYR3_HUMAN
pepinfo	swissprot:RYR3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:RYR3_HUMAN
pepnet	swissprot:RYR3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:RYR3_HUMAN
pepstats	swissprot:RYR3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:RYR3_HUMAN
pepwheel	swissprot:RYR3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:RYR3_HUMAN
pepwindow	swissprot:RYR3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:RYR3_HUMAN
sigcleave	swissprot:RYR3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:RYR3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CLCN5_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P51795-1; Sequence=Displayed; Name=2; IsoId=P51795-2; Sequence=VSP_042046; 
# AltName	CLCN5_HUMAN	Chloride channel protein 5
# AltName	CLCN5_HUMAN	Chloride transporter ClC-5
# BioGrid	107598	4
# CCDS	CCDS14328	-. [P51795-1]
# CCDS	CCDS48115	-. [P51795-2]
# ChiTaRS	CLCN5	human
# DISEASE	CLCN5_HUMAN	Hypophosphatemic rickets, X-linked recessive (XLRHR) [MIM 300554]  A renal disease belonging to the 'Dent disease complex', a group of disorders characterized by proximal renal tubular defect, hypercalciuria, nephrocalcinosis, and renal insufficiency. The spectrum of phenotypic features is remarkably similar in the various disorders, except for differences in the severity of bone deformities and renal impairment. XLRH patients present with rickets or osteomalacia, hypophosphatemia due to decreased renal tubular phosphate reabsorption, hypercalciuria, and low molecular weight proteinuria. Patients develop nephrocalcinosis with progressive renal failure in adulthood. Female carriers may have asymptomatic hypercalciuria or hypophosphatemia only. {ECO 0000269|PubMed 8559248}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CLCN5_HUMAN	Low molecular weight proteinuria with hypercalciuria and nephrocalcinosis (LMWPHN) [MIM 308990]  An X-linked renal disease belonging to the 'Dent disease complex', a group of disorders characterized by proximal renal tubular defect, hypercalciuria, nephrocalcinosis, and renal insufficiency. The spectrum of phenotypic features is remarkably similar in the various disorders, except for differences in the severity of bone deformities and renal impairment. LMWPHN is a slowly progressive disorder. Patients tend to have hypercalciuric nephrocalcinosis without rickets or renal failure. {ECO 0000269|PubMed 11136179, ECO 0000269|PubMed 9062355}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CLCN5_HUMAN	Nephrolithiasis 1 (NPHL1) [MIM 310468]  An X-linked recessive renal disease belonging to the 'Dent disease complex', a group of disorders characterized by proximal renal tubular defect, hypercalciuria, nephrocalcinosis and renal insufficiency. The spectrum of phenotypic features is remarkably similar in the various disorders, except for differences in the severity of bone deformities and renal impairment. Nephrolithiasis type 1 presents with hypercalciuria, nephrocalcinosis, renal stones and renal insufficiency. Patients lack urinary acidification defects, rickets, and osteomalacia. {ECO 0000269|PubMed 8559248}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CLCN5_HUMAN	Nephrolithiasis 2 (NPHL2) [MIM 300009]  An X-linked recessive renal disease belonging to the 'Dent disease complex', a group of disorders characterized by proximal renal tubular defect, hypercalciuria, nephrocalcinosis, and renal insufficiency. The spectrum of phenotypic features is remarkably similar in the various disorders, except for differences in the severity of bone deformities and renal impairment. Nephrolithiasis type 2 patients manifest hypercalciuria, hypophosphatemia, aminoaciduria, nephrocalcinosis and nephrolithiasis, renal insufficiency leading to renal failure in adulthood, rickets (33% of patients) and osteomalacia. {ECO 0000269|PubMed 15086899, ECO 0000269|PubMed 16247550, ECO 0000269|PubMed 16416111, ECO 0000269|PubMed 16822791, ECO 0000269|PubMed 17262170, ECO 0000269|PubMed 18025833, ECO 0000269|PubMed 19657328, ECO 0000269|PubMed 8559248, ECO 0000269|PubMed 9187673, ECO 0000269|PubMed 9259268, ECO 0000269|PubMed 9602200, ECO 0000269|PubMed 9853249}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000307367	ENSP00000304257; ENSG00000171365. [P51795-1]
# Ensembl	ENST00000376088	ENSP00000365256; ENSG00000171365. [P51795-2]
# Ensembl	ENST00000376091	ENSP00000365259; ENSG00000171365. [P51795-2]
# Ensembl	ENST00000376108	ENSP00000365276; ENSG00000171365. [P51795-1]
# ExpressionAtlas	P51795	baseline and differential
# FUNCTION	CLCN5_HUMAN	Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function. 
# GO_component	GO:0000139	Golgi membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005768	endosome; IBA:GO_Central.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0010008	endosome membrane; TAS:Reactome.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0045177	apical part of cell; IDA:UniProtKB.
# GO_function	GO:0005247	voltage-gated chloride channel activity; IBA:GO_Central.
# GO_function	GO:0005254	chloride channel activity; TAS:ProtInc.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0015297	antiporter activity; TAS:Reactome.
# GO_function	GO:0031404	chloride ion binding; IBA:GO_Central.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007588	excretion; TAS:ProtInc.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005768	endosome
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.10.3080.10	-; 3.
# Genevisible	P51795	HS
# HGNC	HGNC:2023	CLCN5
# InterPro	IPR000644	CBS_dom
# InterPro	IPR001807	Cl-channel_volt-gated
# InterPro	IPR002247	Cl_channel-5
# InterPro	IPR014743	Cl-channel_core
# KEGG_Brite	ko04040	Ion channels
# KEGG_Disease	H00214	[Inherited metabolic disease; Connective tissue disease; Urologic disease] Hereditary hypophophatemic rickets with hypercalciuria (HHRH)
# KEGG_Disease	H00694	[Urinary system disease] Low-molecular-weight proteinuria with hypercalciuria and nephrocalcinosis
# MIM	300008	gene
# MIM	300009	phenotype
# MIM	300554	phenotype
# MIM	308990	phenotype
# MIM	310468	phenotype
# MISCELLANEOUS	CLCN5_HUMAN	The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels. 
# Organism	CLCN5_HUMAN	Homo sapiens (Human)
# Orphanet	93622	Dent disease type 1
# PDB	2J9L	X-ray; 2.30 A; A/B/C/D/E/F=571-746
# PDB	2JA3	X-ray; 3.05 A; A/B/C/D/E/F=571-746
# PIR	I37277	I37277
# PRINTS	PR00762	CLCHANNEL
# PRINTS	PR01116	CLCHANNEL5
# PROSITE	PS51371	CBS; 2
# PTM	CLCN5_HUMAN	Ubiquitinated by NEDD4L in the presence of albumin; which promotes endocytosis and proteasomal degradation. {ECO 0000269|PubMed 15489223}. 
# Pfam	PF00571	CBS; 2
# Pfam	PF00654	Voltage_CLC
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	CLCN5_HUMAN	H(+)/Cl(-) exchange transporter 5
# RefSeq	NP_000075	NM_000084.4. [P51795-1]
# RefSeq	NP_001121370	NM_001127898.3. [P51795-2]
# RefSeq	NP_001121371	NM_001127899.3. [P51795-2]
# RefSeq	NP_001269092	NM_001282163.1
# SIMILARITY	Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 2 CBS domains. {ECO:0000255|PROSITE- ProRule	PRU00703}.
# SMART	SM00116	CBS; 2
# SUBCELLULAR LOCATION	CLCN5_HUMAN	Golgi apparatus membrane {ECO 0000269|PubMed 19019917}; Multi-pass membrane protein {ECO 0000269|PubMed 19019917}. Endosome membrane {ECO 0000269|PubMed 19019917}; Multi-pass membrane protein {ECO 0000269|PubMed 19019917}. Cell membrane {ECO 0000269|PubMed 19019917}; Multi-pass membrane protein {ECO 0000269|PubMed 19019917}. 
# SUBUNIT	Interacts with NEDD4 and NEDD4L. {ECO:0000269|PubMed	15489223}. 
# SUPFAM	SSF81340	SSF81340; 3
# TISSUE SPECIFICITY	Kidney. Moderately expressed in aortic vascular smooth muscle and endothelial cells, and at a slightly higher level in the coronary vascular smooth muscle. {ECO:0000269|PubMed	10198195}. 
# UCSC	uc004doq	human. [P51795-1]
# eggNOG	COG0038	LUCA
# eggNOG	KOG0475	Eukaryota
BLAST	swissprot:CLCN5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CLCN5_HUMAN
BioCyc	ZFISH:ENSG00000171365-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000171365-MONOMER
COXPRESdb	1184	http://coxpresdb.jp/data/gene/1184.shtml
CleanEx	HS_CLCN5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CLCN5
DIP	DIP-29263N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29263N
DOI	10.1002/humu.21467	http://dx.doi.org/10.1002/humu.21467
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/geno.1995.9960	http://dx.doi.org/10.1006/geno.1995.9960
DOI	10.1006/jmcc.1998.0901	http://dx.doi.org/10.1006/jmcc.1998.0901
DOI	10.1007/s00240-005-0005-5	http://dx.doi.org/10.1007/s00240-005-0005-5
DOI	10.1007/s004390050448	http://dx.doi.org/10.1007/s004390050448
DOI	10.1007/s10038-005-0317-x	http://dx.doi.org/10.1007/s10038-005-0317-x
DOI	10.1007/s10038-007-0112-y	http://dx.doi.org/10.1007/s10038-007-0112-y
DOI	10.1016/S0022-3476(98)70318-X	http://dx.doi.org/10.1016/S0022-3476(98)70318-X
DOI	10.1016/S0272-6386(01)80067-6	http://dx.doi.org/10.1016/S0272-6386(01)80067-6
DOI	10.1038/379445a0	http://dx.doi.org/10.1038/379445a0
DOI	10.1038/ki.2009.305	http://dx.doi.org/10.1038/ki.2009.305
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/nsmb1188	http://dx.doi.org/10.1038/nsmb1188
DOI	10.1046/j.1523-1755.1998.00203.x	http://dx.doi.org/10.1046/j.1523-1755.1998.00203.x
DOI	10.1074/jbc.M411491200	http://dx.doi.org/10.1074/jbc.M411491200
DOI	10.1093/hmg/6.8.1233	http://dx.doi.org/10.1093/hmg/6.8.1233
DOI	10.1093/ndt/gfl274	http://dx.doi.org/10.1093/ndt/gfl274
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1523-1755.2004.00571.x	http://dx.doi.org/10.1111/j.1523-1755.2004.00571.x
DOI	10.1152/ajprenal.90526.2008	http://dx.doi.org/10.1152/ajprenal.90526.2008
DOI	10.1159/000071883	http://dx.doi.org/10.1159/000071883
DOI	10.1159/000111253	http://dx.doi.org/10.1159/000111253
DOI	10.1172/JCI119262	http://dx.doi.org/10.1172/JCI119262
EMBL	AK056560	http://www.ebi.ac.uk/ena/data/view/AK056560
EMBL	BC130429	http://www.ebi.ac.uk/ena/data/view/BC130429
EMBL	BC130431	http://www.ebi.ac.uk/ena/data/view/BC130431
EMBL	BK000969	http://www.ebi.ac.uk/ena/data/view/BK000969
EMBL	FO393402	http://www.ebi.ac.uk/ena/data/view/FO393402
EMBL	X81836	http://www.ebi.ac.uk/ena/data/view/X81836
EMBL	X91906	http://www.ebi.ac.uk/ena/data/view/X91906
Ensembl	ENST00000307367	http://www.ensembl.org/id/ENST00000307367
Ensembl	ENST00000376088	http://www.ensembl.org/id/ENST00000376088
Ensembl	ENST00000376091	http://www.ensembl.org/id/ENST00000376091
Ensembl	ENST00000376108	http://www.ensembl.org/id/ENST00000376108
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0010008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010008
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0045177	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045177
GO_function	GO:0005247	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005247
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0015297	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297
GO_function	GO:0031404	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031404
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007588
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.10.3080.10	http://www.cathdb.info/version/latest/superfamily/1.10.3080.10
GeneCards	CLCN5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CLCN5
GeneID	1184	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1184
GeneTree	ENSGT00760000119109	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119109
HGNC	HGNC:2023	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2023
HOGENOM	HOG000164493	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000164493&db=HOGENOM6
HOVERGEN	HBG050984	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050984&db=HOVERGEN
HPA	HPA000401	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA000401
HPA	HPA003213	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA003213
InParanoid	P51795	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P51795
InterPro	IPR000644	http://www.ebi.ac.uk/interpro/entry/IPR000644
InterPro	IPR001807	http://www.ebi.ac.uk/interpro/entry/IPR001807
InterPro	IPR002247	http://www.ebi.ac.uk/interpro/entry/IPR002247
InterPro	IPR014743	http://www.ebi.ac.uk/interpro/entry/IPR014743
Jabion	1184	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1184
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00214	http://www.genome.jp/dbget-bin/www_bget?H00214
KEGG_Disease	H00694	http://www.genome.jp/dbget-bin/www_bget?H00694
KEGG_Gene	hsa:1184	http://www.genome.jp/dbget-bin/www_bget?hsa:1184
KEGG_Orthology	KO:K05014	http://www.genome.jp/dbget-bin/www_bget?KO:K05014
MIM	300008	http://www.ncbi.nlm.nih.gov/omim/300008
MIM	300009	http://www.ncbi.nlm.nih.gov/omim/300009
MIM	300554	http://www.ncbi.nlm.nih.gov/omim/300554
MIM	308990	http://www.ncbi.nlm.nih.gov/omim/308990
MIM	310468	http://www.ncbi.nlm.nih.gov/omim/310468
MINT	MINT-1524912	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1524912
OMA	LMDIPGT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LMDIPGT
Orphanet	93622	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=93622
OrthoDB	EOG091G01YH	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01YH
PDB	2J9L	http://www.ebi.ac.uk/pdbe-srv/view/entry/2J9L
PDB	2JA3	http://www.ebi.ac.uk/pdbe-srv/view/entry/2JA3
PDBsum	2J9L	http://www.ebi.ac.uk/pdbsum/2J9L
PDBsum	2JA3	http://www.ebi.ac.uk/pdbsum/2JA3
PRINTS	PR00762	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00762
PRINTS	PR01116	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01116
PROSITE	PS51371	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51371
PSORT	swissprot:CLCN5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CLCN5_HUMAN
PSORT-B	swissprot:CLCN5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CLCN5_HUMAN
PSORT2	swissprot:CLCN5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CLCN5_HUMAN
Pfam	PF00571	http://pfam.xfam.org/family/PF00571
Pfam	PF00654	http://pfam.xfam.org/family/PF00654
PharmGKB	PA26550	http://www.pharmgkb.org/do/serve?objId=PA26550&objCls=Gene
Phobius	swissprot:CLCN5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CLCN5_HUMAN
PhylomeDB	P51795	http://phylomedb.org/?seqid=P51795
ProteinModelPortal	P51795	http://www.proteinmodelportal.org/query/uniprot/P51795
PubMed	10198195	http://www.ncbi.nlm.nih.gov/pubmed/10198195
PubMed	11136179	http://www.ncbi.nlm.nih.gov/pubmed/11136179
PubMed	12886045	http://www.ncbi.nlm.nih.gov/pubmed/12886045
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15086899	http://www.ncbi.nlm.nih.gov/pubmed/15086899
PubMed	15489223	http://www.ncbi.nlm.nih.gov/pubmed/15489223
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	16247550	http://www.ncbi.nlm.nih.gov/pubmed/16247550
PubMed	16416111	http://www.ncbi.nlm.nih.gov/pubmed/16416111
PubMed	16822791	http://www.ncbi.nlm.nih.gov/pubmed/16822791
PubMed	17195847	http://www.ncbi.nlm.nih.gov/pubmed/17195847
PubMed	17262170	http://www.ncbi.nlm.nih.gov/pubmed/17262170
PubMed	18025833	http://www.ncbi.nlm.nih.gov/pubmed/18025833
PubMed	19019917	http://www.ncbi.nlm.nih.gov/pubmed/19019917
PubMed	19657328	http://www.ncbi.nlm.nih.gov/pubmed/19657328
PubMed	21305656	http://www.ncbi.nlm.nih.gov/pubmed/21305656
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	7874126	http://www.ncbi.nlm.nih.gov/pubmed/7874126
PubMed	8559248	http://www.ncbi.nlm.nih.gov/pubmed/8559248
PubMed	8575751	http://www.ncbi.nlm.nih.gov/pubmed/8575751
PubMed	9062355	http://www.ncbi.nlm.nih.gov/pubmed/9062355
PubMed	9187673	http://www.ncbi.nlm.nih.gov/pubmed/9187673
PubMed	9259268	http://www.ncbi.nlm.nih.gov/pubmed/9259268
PubMed	9602200	http://www.ncbi.nlm.nih.gov/pubmed/9602200
PubMed	9853249	http://www.ncbi.nlm.nih.gov/pubmed/9853249
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_000075	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000075
RefSeq	NP_001121370	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001121370
RefSeq	NP_001121371	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001121371
RefSeq	NP_001269092	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269092
SMART	SM00116	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00116
SMR	P51795	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P51795
STRING	9606.ENSP00000365256	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000365256&targetmode=cogs
SUPFAM	SSF81340	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81340
UCSC	uc004doq	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004doq&org=rat
UniGene	Hs.166486	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.166486
UniGene	Hs.745501	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.745501
UniProtKB	CLCN5_HUMAN	http://www.uniprot.org/uniprot/CLCN5_HUMAN
UniProtKB-AC	P51795	http://www.uniprot.org/uniprot/P51795
charge	swissprot:CLCN5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CLCN5_HUMAN
eggNOG	COG0038	http://eggnogapi.embl.de/nog_data/html/tree/COG0038
eggNOG	KOG0475	http://eggnogapi.embl.de/nog_data/html/tree/KOG0475
epestfind	swissprot:CLCN5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CLCN5_HUMAN
garnier	swissprot:CLCN5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CLCN5_HUMAN
helixturnhelix	swissprot:CLCN5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLCN5_HUMAN
hmoment	swissprot:CLCN5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CLCN5_HUMAN
iep	swissprot:CLCN5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CLCN5_HUMAN
inforesidue	swissprot:CLCN5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CLCN5_HUMAN
neXtProt	NX_P51795	http://www.nextprot.org/db/entry/NX_P51795
octanol	swissprot:CLCN5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CLCN5_HUMAN
pepcoil	swissprot:CLCN5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CLCN5_HUMAN
pepdigest	swissprot:CLCN5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CLCN5_HUMAN
pepinfo	swissprot:CLCN5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CLCN5_HUMAN
pepnet	swissprot:CLCN5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CLCN5_HUMAN
pepstats	swissprot:CLCN5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CLCN5_HUMAN
pepwheel	swissprot:CLCN5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CLCN5_HUMAN
pepwindow	swissprot:CLCN5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CLCN5_HUMAN
sigcleave	swissprot:CLCN5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CLCN5_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GTR2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P11168-1; Sequence=Displayed; Name=2; IsoId=P11168-2; Sequence=VSP_054835; 
# AltName	GTR2_HUMAN	Glucose transporter type 2, liver
# BioGrid	112405	4
# CCDS	CCDS3215	-. [P11168-1]
# CDD	cd06174	MFS
# DISEASE	GTR2_HUMAN	Fanconi-Bickel syndrome (FBS) [MIM 227810]  Rare, well- defined clinical entity, inherited in an autosomal recessive mode and characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose. {ECO 0000269|PubMed 10987651, ECO 0000269|PubMed 11044475}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00428	Streptozocin
# Ensembl	ENST00000314251	ENSP00000323568; ENSG00000163581. [P11168-1]
# ExpressionAtlas	P11168	baseline and differential
# FUNCTION	GTR2_HUMAN	Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. 
# GO_component	GO:0005737	cytoplasm; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0005903	brush border; IEA:Ensembl.
# GO_component	GO:0005911	cell-cell junction; IEA:Ensembl.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0016324	apical plasma membrane; IEA:Ensembl.
# GO_function	GO:0005355	glucose transmembrane transporter activity; EXP:Reactome.
# GO_function	GO:0015149	hexose transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0033300	dehydroascorbic acid transporter activity; IEA:Ensembl.
# GO_function	GO:0055056	D-glucose transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0005975	carbohydrate metabolic process; TAS:ProtInc.
# GO_process	GO:0008645	hexose transport; TAS:Reactome.
# GO_process	GO:0015758	glucose transport; TAS:Reactome.
# GO_process	GO:0050796	regulation of insulin secretion; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0005975	carbohydrate metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Genevisible	P11168	HS
# HGNC	HGNC:11006	SLC2A2
# InterPro	IPR002440	Glc_transpt_2
# InterPro	IPR003663	Sugar/inositol_transpt
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR005829	Sugar_transporter_CS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H00069	[Inherited metabolic disease] Glycogen synthase deficiency (GSD type 0)
# KEGG_Pathway	ko04930	Type II diabetes mellitus
# KEGG_Pathway	ko04950	Maturity onset diabetes of the young
# KEGG_Pathway	ko04973	Carbohydrate digestion and absorption
# MIM	138160	gene
# MIM	227810	phenotype
# Organism	GTR2_HUMAN	Homo sapiens (Human)
# Orphanet	2088	Glycogen storage disease due to GLUT2 deficiency
# PIR	A31318	A31318
# PRINTS	PR00171	SUGRTRNSPORT
# PRINTS	PR01191	GLUCTRSPORT2
# PROSITE	PS00216	SUGAR_TRANSPORT_1
# PROSITE	PS00217	SUGAR_TRANSPORT_2
# PROSITE	PS50850	MFS
# PTM	GTR2_HUMAN	N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells. {ECO 0000250}. 
# Pfam	PF00083	Sugar_tr
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-189200	Hexose transport
# Reactome	R-HSA-210745	Regulation of gene expression in beta cells
# Reactome	R-HSA-422356	Regulation of insulin secretion
# Reactome	R-HSA-428790	Facilitative Na+-independent glucose transporters
# Reactome	R-HSA-70153	Glucose transport
# RecName	GTR2_HUMAN	Solute carrier family 2, facilitated glucose transporter member 2
# RefSeq	NP_000331	NM_000340.1. [P11168-1]
# RefSeq	NP_001265587	NM_001278658.1. [P11168-2]
# RefSeq	NP_001265588	NM_001278659.1
# SIMILARITY	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	GTR2_HUMAN	Membrane; Multi-pass membrane protein. 
# SUPFAM	SSF103473	SSF103473; 3
# TCDB	2.A.1.1.29	the major facilitator superfamily (mfs)
# TIGRFAMs	TIGR00879	SP
# TISSUE SPECIFICITY	GTR2_HUMAN	Liver, insulin-producing beta cell, small intestine and kidney. 
# UCSC	uc003fhe	human. [P11168-1]
# WEB RESOURCE	GTR2_HUMAN	Name=Wikipedia; Note=GLUT2 entry; URL="https //en.wikipedia.org/wiki/GLUT2";
# eggNOG	COG0477	LUCA
# eggNOG	KOG0569	Eukaryota
BLAST	swissprot:GTR2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GTR2_HUMAN
BioCyc	ZFISH:ENSG00000163581-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000163581-MONOMER
COXPRESdb	6514	http://coxpresdb.jp/data/gene/6514.shtml
CleanEx	HS_SLC2A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC2A2
DOI	10.1007/BF00408481	http://dx.doi.org/10.1007/BF00408481
DOI	10.1007/s004390051095	http://dx.doi.org/10.1007/s004390051095
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.85.15.5434	http://dx.doi.org/10.1073/pnas.85.15.5434
DOI	10.1203/00006450-200011000-00005	http://dx.doi.org/10.1203/00006450-200011000-00005
DOI	10.1210/jc.80.11.3131	http://dx.doi.org/10.1210/jc.80.11.3131
DrugBank	DB00428	http://www.drugbank.ca/drugs/DB00428
EMBL	AC061708	http://www.ebi.ac.uk/ena/data/view/AC061708
EMBL	AC092918	http://www.ebi.ac.uk/ena/data/view/AC092918
EMBL	AK290846	http://www.ebi.ac.uk/ena/data/view/AK290846
EMBL	AK298418	http://www.ebi.ac.uk/ena/data/view/AK298418
EMBL	AK313622	http://www.ebi.ac.uk/ena/data/view/AK313622
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
EMBL	J03810	http://www.ebi.ac.uk/ena/data/view/J03810
Ensembl	ENST00000314251	http://www.ensembl.org/id/ENST00000314251
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005903	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005903
GO_component	GO:0005911	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005911
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_function	GO:0005355	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005355
GO_function	GO:0015149	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015149
GO_function	GO:0033300	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033300
GO_function	GO:0055056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055056
GO_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GO_process	GO:0008645	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008645
GO_process	GO:0015758	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015758
GO_process	GO:0050796	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050796
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	SLC2A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC2A2
GeneID	6514	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6514
GeneTree	ENSGT00760000119022	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119022
HGNC	HGNC:11006	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11006
HOGENOM	HOG000202871	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202871&db=HOGENOM6
HOVERGEN	HBG014816	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG014816&db=HOVERGEN
HPA	CAB010444	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB010444
HPA	HPA028997	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA028997
InParanoid	P11168	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P11168
InterPro	IPR002440	http://www.ebi.ac.uk/interpro/entry/IPR002440
InterPro	IPR003663	http://www.ebi.ac.uk/interpro/entry/IPR003663
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR005829	http://www.ebi.ac.uk/interpro/entry/IPR005829
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	6514	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6514
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00069	http://www.genome.jp/dbget-bin/www_bget?H00069
KEGG_Gene	hsa:6514	http://www.genome.jp/dbget-bin/www_bget?hsa:6514
KEGG_Orthology	KO:K07593	http://www.genome.jp/dbget-bin/www_bget?KO:K07593
KEGG_Pathway	ko04930	http://www.genome.jp/kegg-bin/show_pathway?ko04930
KEGG_Pathway	ko04950	http://www.genome.jp/kegg-bin/show_pathway?ko04950
KEGG_Pathway	ko04973	http://www.genome.jp/kegg-bin/show_pathway?ko04973
MIM	138160	http://www.ncbi.nlm.nih.gov/omim/138160
MIM	227810	http://www.ncbi.nlm.nih.gov/omim/227810
OMA	YDLWHIL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YDLWHIL
Orphanet	2088	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=2088
OrthoDB	EOG091G0A9K	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0A9K
PRINTS	PR00171	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00171
PRINTS	PR01191	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01191
PROSITE	PS00216	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00216
PROSITE	PS00217	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00217
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:GTR2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GTR2_HUMAN
PSORT-B	swissprot:GTR2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GTR2_HUMAN
PSORT2	swissprot:GTR2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GTR2_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
PharmGKB	PA35876	http://www.pharmgkb.org/do/serve?objId=PA35876&objCls=Gene
Phobius	swissprot:GTR2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GTR2_HUMAN
PhylomeDB	P11168	http://phylomedb.org/?seqid=P11168
ProteinModelPortal	P11168	http://www.proteinmodelportal.org/query/uniprot/P11168
PubMed	10987651	http://www.ncbi.nlm.nih.gov/pubmed/10987651
PubMed	11044475	http://www.ncbi.nlm.nih.gov/pubmed/11044475
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	3399500	http://www.ncbi.nlm.nih.gov/pubmed/3399500
PubMed	7593414	http://www.ncbi.nlm.nih.gov/pubmed/7593414
PubMed	8027028	http://www.ncbi.nlm.nih.gov/pubmed/8027028
PubMed	8063045	http://www.ncbi.nlm.nih.gov/pubmed/8063045
Reactome	R-HSA-189200	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-189200
Reactome	R-HSA-210745	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-210745
Reactome	R-HSA-422356	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-422356
Reactome	R-HSA-428790	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428790
Reactome	R-HSA-70153	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-70153
RefSeq	NP_000331	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000331
RefSeq	NP_001265587	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001265587
RefSeq	NP_001265588	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001265588
STRING	9606.ENSP00000323568	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000323568&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.1.29	http://www.tcdb.org/search/result.php?tc=2.A.1.1.29
TIGRFAMs	TIGR00879	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00879
UCSC	uc003fhe	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003fhe&org=rat
UniGene	Hs.167584	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.167584
UniProtKB	GTR2_HUMAN	http://www.uniprot.org/uniprot/GTR2_HUMAN
UniProtKB-AC	P11168	http://www.uniprot.org/uniprot/P11168
charge	swissprot:GTR2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GTR2_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG0569	http://eggnogapi.embl.de/nog_data/html/tree/KOG0569
epestfind	swissprot:GTR2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GTR2_HUMAN
garnier	swissprot:GTR2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GTR2_HUMAN
helixturnhelix	swissprot:GTR2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GTR2_HUMAN
hmoment	swissprot:GTR2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GTR2_HUMAN
iep	swissprot:GTR2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GTR2_HUMAN
inforesidue	swissprot:GTR2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GTR2_HUMAN
neXtProt	NX_P11168	http://www.nextprot.org/db/entry/NX_P11168
octanol	swissprot:GTR2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GTR2_HUMAN
pepcoil	swissprot:GTR2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GTR2_HUMAN
pepdigest	swissprot:GTR2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GTR2_HUMAN
pepinfo	swissprot:GTR2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GTR2_HUMAN
pepnet	swissprot:GTR2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GTR2_HUMAN
pepstats	swissprot:GTR2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GTR2_HUMAN
pepwheel	swissprot:GTR2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GTR2_HUMAN
pepwindow	swissprot:GTR2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GTR2_HUMAN
sigcleave	swissprot:GTR2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GTR2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SL9A8_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y2E8-1; Sequence=Displayed; Name=2; IsoId=Q9Y2E8-2; Sequence=VSP_037686; 
# AltName	SL9A8_HUMAN	Na(+)/H(+) exchanger 8
# AltName	SL9A8_HUMAN	Solute carrier family 9 member 8
# BioGrid	116906	2
# CCDS	CCDS13421	-. [Q9Y2E8-1]
# CCDS	CCDS58774	-. [Q9Y2E8-2]
# ChiTaRS	SLC9A8	human
# Ensembl	ENST00000361573	ENSP00000354966; ENSG00000197818. [Q9Y2E8-1]
# Ensembl	ENST00000417961	ENSP00000416418; ENSG00000197818. [Q9Y2E8-2]
# FUNCTION	SL9A8_HUMAN	Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. {ECO 0000269|PubMed 15522866}. 
# GO_component	GO:0000139	Golgi membrane; TAS:Reactome.
# GO_component	GO:0005794	Golgi apparatus; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	SL9A8_HUMAN	GO 0015385 sodium proton antiporter activity; IBA GO_Central.
# GO_function	SL9A8_HUMAN	GO 0015386 potassium proton antiporter activity; IBA GO_Central.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0051453	regulation of intracellular pH; IBA:GO_Central.
# GO_process	GO:0071805	potassium ion transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9Y2E8	HS
# HGNC	HGNC:20728	SLC9A8
# IntAct	Q9Y2E8	2
# InterPro	IPR004709	NaH_exchanger
# InterPro	IPR006153	Cation/H_exchanger
# InterPro	IPR018409	Na/H_exchanger_8
# InterPro	IPR018422	Cation/H_exchanger_CPA1
# KEGG_Brite	ko02001	Solute carrier family
# MIM	612730	gene
# Organism	SL9A8_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10110	PTHR10110
# PANTHER	PTHR10110:SF122	PTHR10110:SF122
# PRINTS	PR01084	NAHEXCHNGR
# Pfam	PF00999	Na_H_Exchanger
# Proteomes	UP000005640	Chromosome 20
# Reactome	R-HSA-425986	Sodium/Proton exchangers
# RecName	SL9A8_HUMAN	Sodium/hydrogen exchanger 8
# RefSeq	NP_001247420	NM_001260491.1. [Q9Y2E8-2]
# RefSeq	NP_056081	NM_015266.2. [Q9Y2E8-1]
# SEQUENCE CAUTION	Sequence=BAA76783.2; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	SL9A8_HUMAN	Golgi apparatus membrane {ECO 0000269|PubMed 15522866}; Multi-pass membrane protein {ECO 0000269|PubMed 15522866}. 
# TCDB	2.A.36.1:the monovalent cation	proton antiporter-1 (cpa1) family
# TIGRFAMs	TIGR00840	b_cpa1
# TISSUE SPECIFICITY	Ubiquitous. Strongly expressed in skeletal muscle and kidney. {ECO:0000269|PubMed	15522866}. 
# UCSC	uc002xuv	human. [Q9Y2E8-1]
# eggNOG	COG0025	LUCA
# eggNOG	KOG1965	Eukaryota
BLAST	swissprot:SL9A8_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SL9A8_HUMAN
BioCyc	ZFISH:G66-31487-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31487-MONOMER
COXPRESdb	23315	http://coxpresdb.jp/data/gene/23315.shtml
CleanEx	HS_SLC9A8	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC9A8
DOI	10.1038/414865a	http://dx.doi.org/10.1038/414865a
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M410041200	http://dx.doi.org/10.1074/jbc.M410041200
DOI	10.1093/dnares/6.1.63	http://dx.doi.org/10.1093/dnares/6.1.63
DOI	10.1093/dnares/9.3.99	http://dx.doi.org/10.1093/dnares/9.3.99
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AB023156	http://www.ebi.ac.uk/ena/data/view/AB023156
EMBL	AK131001	http://www.ebi.ac.uk/ena/data/view/AK131001
EMBL	AK300318	http://www.ebi.ac.uk/ena/data/view/AK300318
EMBL	AL031685	http://www.ebi.ac.uk/ena/data/view/AL031685
EMBL	AL031685	http://www.ebi.ac.uk/ena/data/view/AL031685
EMBL	AL162615	http://www.ebi.ac.uk/ena/data/view/AL162615
EMBL	AL162615	http://www.ebi.ac.uk/ena/data/view/AL162615
EMBL	BC112213	http://www.ebi.ac.uk/ena/data/view/BC112213
EMBL	CH471077	http://www.ebi.ac.uk/ena/data/view/CH471077
EMBL	CR749638	http://www.ebi.ac.uk/ena/data/view/CR749638
Ensembl	ENST00000361573	http://www.ensembl.org/id/ENST00000361573
Ensembl	ENST00000417961	http://www.ensembl.org/id/ENST00000417961
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015385
GO_function	GO:0015386	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015386
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC9A8	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC9A8
GeneID	23315	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23315
GeneTree	ENSGT00760000119074	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119074
HGNC	HGNC:20728	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20728
HOGENOM	HOG000172307	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000172307&db=HOGENOM6
HOVERGEN	HBG056815	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG056815&db=HOVERGEN
HPA	CAB033682	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB033682
InParanoid	Q9Y2E8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y2E8
IntAct	Q9Y2E8	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9Y2E8*
InterPro	IPR004709	http://www.ebi.ac.uk/interpro/entry/IPR004709
InterPro	IPR006153	http://www.ebi.ac.uk/interpro/entry/IPR006153
InterPro	IPR018409	http://www.ebi.ac.uk/interpro/entry/IPR018409
InterPro	IPR018422	http://www.ebi.ac.uk/interpro/entry/IPR018422
Jabion	23315	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=23315
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:23315	http://www.genome.jp/dbget-bin/www_bget?hsa:23315
KEGG_Orthology	KO:K14724	http://www.genome.jp/dbget-bin/www_bget?KO:K14724
MIM	612730	http://www.ncbi.nlm.nih.gov/omim/612730
OMA	DVIYKMT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DVIYKMT
OrthoDB	EOG091G05T4	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05T4
PANTHER	PTHR10110	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10110
PANTHER	PTHR10110:SF122	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10110:SF122
PRINTS	PR01084	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01084
PSORT	swissprot:SL9A8_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SL9A8_HUMAN
PSORT-B	swissprot:SL9A8_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SL9A8_HUMAN
PSORT2	swissprot:SL9A8_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SL9A8_HUMAN
Pfam	PF00999	http://pfam.xfam.org/family/PF00999
PharmGKB	PA134924114	http://www.pharmgkb.org/do/serve?objId=PA134924114&objCls=Gene
Phobius	swissprot:SL9A8_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SL9A8_HUMAN
PhylomeDB	Q9Y2E8	http://phylomedb.org/?seqid=Q9Y2E8
ProteinModelPortal	Q9Y2E8	http://www.proteinmodelportal.org/query/uniprot/Q9Y2E8
PubMed	10231032	http://www.ncbi.nlm.nih.gov/pubmed/10231032
PubMed	11780052	http://www.ncbi.nlm.nih.gov/pubmed/11780052
PubMed	12168954	http://www.ncbi.nlm.nih.gov/pubmed/12168954
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15522866	http://www.ncbi.nlm.nih.gov/pubmed/15522866
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
Reactome	R-HSA-425986	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425986
RefSeq	NP_001247420	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001247420
RefSeq	NP_056081	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_056081
SMR	Q9Y2E8	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9Y2E8
STRING	9606.ENSP00000354966	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000354966&targetmode=cogs
TCDB	2.A.36.1	http://www.tcdb.org/search/result.php?tc=2.A.36.1
TIGRFAMs	TIGR00840	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00840
UCSC	uc002xuv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002xuv&org=rat
UniGene	Hs.444202	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.444202
UniProtKB	SL9A8_HUMAN	http://www.uniprot.org/uniprot/SL9A8_HUMAN
UniProtKB-AC	Q9Y2E8	http://www.uniprot.org/uniprot/Q9Y2E8
charge	swissprot:SL9A8_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SL9A8_HUMAN
eggNOG	COG0025	http://eggnogapi.embl.de/nog_data/html/tree/COG0025
eggNOG	KOG1965	http://eggnogapi.embl.de/nog_data/html/tree/KOG1965
epestfind	swissprot:SL9A8_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SL9A8_HUMAN
garnier	swissprot:SL9A8_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SL9A8_HUMAN
helixturnhelix	swissprot:SL9A8_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SL9A8_HUMAN
hmoment	swissprot:SL9A8_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SL9A8_HUMAN
iep	swissprot:SL9A8_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SL9A8_HUMAN
inforesidue	swissprot:SL9A8_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SL9A8_HUMAN
neXtProt	NX_Q9Y2E8	http://www.nextprot.org/db/entry/NX_Q9Y2E8
octanol	swissprot:SL9A8_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SL9A8_HUMAN
pepcoil	swissprot:SL9A8_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SL9A8_HUMAN
pepdigest	swissprot:SL9A8_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SL9A8_HUMAN
pepinfo	swissprot:SL9A8_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SL9A8_HUMAN
pepnet	swissprot:SL9A8_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SL9A8_HUMAN
pepstats	swissprot:SL9A8_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SL9A8_HUMAN
pepwheel	swissprot:SL9A8_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SL9A8_HUMAN
pepwindow	swissprot:SL9A8_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SL9A8_HUMAN
sigcleave	swissprot:SL9A8_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SL9A8_HUMAN
## Database	ID	URL or Descriptions
# AltName	MPRD_HUMAN	46 kDa mannose 6-phosphate receptor
# BioGrid	110251	24
# DOMAIN	MPRD_HUMAN	The extracellular domain is homologous to the repeating units (of approximately 147 AA) of the cation-independent mannose 6-phosphate receptor. 
# DrugBank	DB01272	Alglucosidase alfa
# Ensembl	ENST00000000412	ENSP00000000412; ENSG00000003056
# ExpressionAtlas	P20645	baseline and differential
# FUNCTION	MPRD_HUMAN	Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. 
# GO_component	GO:0005765	lysosomal membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005768	endosome; IDA:MGI.
# GO_component	GO:0005770	late endosome; IEA:Ensembl.
# GO_component	GO:0005802	trans-Golgi network; IBA:GO_Central.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0030133	transport vesicle; TAS:Reactome.
# GO_component	GO:0032588	trans-Golgi network membrane; TAS:Reactome.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IDA:UniProtKB.
# GO_function	GO:0004888	transmembrane signaling receptor activity; TAS:ProtInc.
# GO_function	GO:0005537	mannose binding; IEA:InterPro.
# GO_function	GO:0015578	mannose transmembrane transporter activity; IEA:InterPro.
# GO_function	GO:1905394	retromer complex binding; IMP:ParkinsonsUK-UCL.
# GO_process	GO:0006898	receptor-mediated endocytosis; TAS:ProtInc.
# GO_process	GO:0008333	endosome to lysosome transport; TAS:ProtInc.
# GO_process	GO:0033299	secretion of lysosomal enzymes; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007034	vacuolar transport
# GOslim_process	GO:0016192	vesicle-mediated transport
# Gene3D	2.70.130.10	-; 1.
# Genevisible	P20645	HS
# HGNC	HGNC:6752	M6PR
# IntAct	P20645	5
# InterPro	IPR000296	Man_6_P_rcpt
# InterPro	IPR009011	Man6P_isomerase_rcpt-bd_dom
# InterPro	IPR028927	Man-6-P_rcpt
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04091	 Glycan binding proteins
# KEGG_Pathway	ko04142	Lysosome
# KEGG_Pathway	ko04145	Phagosome
# MIM	154540	gene
# MISCELLANEOUS	MPRD_HUMAN	This receptor has optimal binding in the presence of divalent cations.
# Organism	MPRD_HUMAN	Homo sapiens (Human)
# PDB	1JUQ	X-ray; 2.20 A; E/F/G/H=265-277
# PIR	S15368	A32700
# PRINTS	PR00715	MAN6PRECEPTR
# Pfam	PF02157	Man-6-P_recep
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-432720	Lysosome Vesicle Biogenesis
# Reactome	R-HSA-6811440	Retrograde transport at the Trans-Golgi-Network
# Reactome	R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis
# Reactome	R-HSA-8856828	Clathrin-mediated endocytosis
# RecName	MPRD_HUMAN	Cation-dependent mannose-6-phosphate receptor
# RefSeq	NP_002346	NM_002355.3
# RefSeq	XP_005253433	XM_005253376.2
# SUBCELLULAR LOCATION	MPRD_HUMAN	Lysosome membrane; Single-pass type I membrane protein. 
# SUBUNIT	MPRD_HUMAN	Homodimer. Binds GGA1, GGA2 and GGA3. 
# SUPFAM	SSF50911	SSF50911
# UCSC	uc001qvf	human
# eggNOG	ENOG410IK0D	Eukaryota
# eggNOG	ENOG4111GED	LUCA
BLAST	swissprot:MPRD_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MPRD_HUMAN
BioCyc	ZFISH:ENSG00000003056-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000003056-MONOMER
COXPRESdb	4074	http://coxpresdb.jp/data/gene/4074.shtml
CleanEx	HS_M6PR	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_M6PR
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.84.16.5575	http://dx.doi.org/10.1073/pnas.84.16.5575
DOI	10.1074/jbc.M201879200	http://dx.doi.org/10.1074/jbc.M201879200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1432-1033.1991.tb15877.x	http://dx.doi.org/10.1111/j.1432-1033.1991.tb15877.x
DOI	10.1126/science.1060750	http://dx.doi.org/10.1126/science.1060750
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DrugBank	DB01272	http://www.drugbank.ca/drugs/DB01272
EMBL	AK291143	http://www.ebi.ac.uk/ena/data/view/AK291143
EMBL	BC024206	http://www.ebi.ac.uk/ena/data/view/BC024206
EMBL	CH471116	http://www.ebi.ac.uk/ena/data/view/CH471116
EMBL	CH471116	http://www.ebi.ac.uk/ena/data/view/CH471116
EMBL	CH471116	http://www.ebi.ac.uk/ena/data/view/CH471116
EMBL	CH471116	http://www.ebi.ac.uk/ena/data/view/CH471116
EMBL	M16985	http://www.ebi.ac.uk/ena/data/view/M16985
EMBL	X56254	http://www.ebi.ac.uk/ena/data/view/X56254
EMBL	X56255	http://www.ebi.ac.uk/ena/data/view/X56255
EMBL	X56256	http://www.ebi.ac.uk/ena/data/view/X56256
EMBL	X56257	http://www.ebi.ac.uk/ena/data/view/X56257
Ensembl	ENST00000000412	http://www.ensembl.org/id/ENST00000000412
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GO_component	GO:0005770	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005770
GO_component	GO:0005802	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005802
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0030133	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030133
GO_component	GO:0032588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032588
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_function	GO:0004888	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004888
GO_function	GO:0005537	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005537
GO_function	GO:0015578	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015578
GO_function	GO:1905394	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1905394
GO_process	GO:0006898	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006898
GO_process	GO:0008333	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008333
GO_process	GO:0033299	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033299
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007034	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007034
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
Gene3D	2.70.130.10	http://www.cathdb.info/version/latest/superfamily/2.70.130.10
GeneCards	M6PR	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=M6PR
GeneID	4074	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4074
GeneTree	ENSGT00390000002109	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002109
HGNC	HGNC:6752	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6752
HOGENOM	HOG000013085	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000013085&db=HOGENOM6
HOVERGEN	HBG006395	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006395&db=HOVERGEN
HPA	CAB034464	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB034464
HPA	HPA040445	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA040445
InParanoid	P20645	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P20645
IntAct	P20645	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P20645*
InterPro	IPR000296	http://www.ebi.ac.uk/interpro/entry/IPR000296
InterPro	IPR009011	http://www.ebi.ac.uk/interpro/entry/IPR009011
InterPro	IPR028927	http://www.ebi.ac.uk/interpro/entry/IPR028927
Jabion	4074	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=4074
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04091	http://www.genome.jp/dbget-bin/www_bget?ko04091
KEGG_Gene	hsa:4074	http://www.genome.jp/dbget-bin/www_bget?hsa:4074
KEGG_Orthology	KO:K10089	http://www.genome.jp/dbget-bin/www_bget?KO:K10089
KEGG_Pathway	ko04142	http://www.genome.jp/kegg-bin/show_pathway?ko04142
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
MIM	154540	http://www.ncbi.nlm.nih.gov/omim/154540
MINT	MINT-4999970	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4999970
OMA	INETQVF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=INETQVF
OrthoDB	EOG091G0WP5	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0WP5
PDB	1JUQ	http://www.ebi.ac.uk/pdbe-srv/view/entry/1JUQ
PDBsum	1JUQ	http://www.ebi.ac.uk/pdbsum/1JUQ
PRINTS	PR00715	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00715
PSORT	swissprot:MPRD_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MPRD_HUMAN
PSORT-B	swissprot:MPRD_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MPRD_HUMAN
PSORT2	swissprot:MPRD_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MPRD_HUMAN
Pfam	PF02157	http://pfam.xfam.org/family/PF02157
PharmGKB	PA30513	http://www.pharmgkb.org/do/serve?objId=PA30513&objCls=Gene
Phobius	swissprot:MPRD_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MPRD_HUMAN
PhylomeDB	P20645	http://phylomedb.org/?seqid=P20645
ProteinModelPortal	P20645	http://www.proteinmodelportal.org/query/uniprot/P20645
PubMed	11387475	http://www.ncbi.nlm.nih.gov/pubmed/11387475
PubMed	11886874	http://www.ncbi.nlm.nih.gov/pubmed/11886874
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	1849818	http://www.ncbi.nlm.nih.gov/pubmed/1849818
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	2441386	http://www.ncbi.nlm.nih.gov/pubmed/2441386
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-432720	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432720
Reactome	R-HSA-6811440	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6811440
Reactome	R-HSA-8856825	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8856825
Reactome	R-HSA-8856828	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8856828
RefSeq	NP_002346	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002346
RefSeq	XP_005253433	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005253433
SMR	P20645	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P20645
STRING	9606.ENSP00000000412	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000000412&targetmode=cogs
SUPFAM	SSF50911	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50911
UCSC	uc001qvf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001qvf&org=rat
UniGene	Hs.134084	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.134084
UniGene	Hs.744902	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.744902
UniProtKB	MPRD_HUMAN	http://www.uniprot.org/uniprot/MPRD_HUMAN
UniProtKB-AC	P20645	http://www.uniprot.org/uniprot/P20645
charge	swissprot:MPRD_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MPRD_HUMAN
eggNOG	ENOG410IK0D	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IK0D
eggNOG	ENOG4111GED	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111GED
epestfind	swissprot:MPRD_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MPRD_HUMAN
garnier	swissprot:MPRD_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MPRD_HUMAN
helixturnhelix	swissprot:MPRD_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MPRD_HUMAN
hmoment	swissprot:MPRD_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MPRD_HUMAN
iep	swissprot:MPRD_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MPRD_HUMAN
inforesidue	swissprot:MPRD_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MPRD_HUMAN
neXtProt	NX_P20645	http://www.nextprot.org/db/entry/NX_P20645
octanol	swissprot:MPRD_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MPRD_HUMAN
pepcoil	swissprot:MPRD_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MPRD_HUMAN
pepdigest	swissprot:MPRD_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MPRD_HUMAN
pepinfo	swissprot:MPRD_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MPRD_HUMAN
pepnet	swissprot:MPRD_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MPRD_HUMAN
pepstats	swissprot:MPRD_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MPRD_HUMAN
pepwheel	swissprot:MPRD_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MPRD_HUMAN
pepwindow	swissprot:MPRD_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MPRD_HUMAN
sigcleave	swissprot:MPRD_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MPRD_HUMAN
## Database	ID	URL or Descriptions
# AltName	ORNT2_HUMAN	Solute carrier family 25 member 2
# BioGrid	123796	2
# DrugBank	DB00129	L-Ornithine
# Ensembl	ENST00000239451	ENSP00000239451; ENSG00000120329
# FUNCTION	ORNT2_HUMAN	Ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix. 
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0000064	L-ornithine transmembrane transporter activity; EXP:Reactome.
# GO_process	GO:0000050	urea cycle; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0071941	nitrogen cycle metabolic process
# Gene3D	1.50.40.10	-; 1.
# Genevisible	Q9BXI2	HS
# HGNC	HGNC:22921	SLC25A2
# InterPro	IPR018108	Mitochondrial_sb/sol_carrier
# InterPro	IPR023395	Mt_carrier_dom
# KEGG_Brite	ko02001	Solute carrier family
# MIM	608157	gene
# Organism	ORNT2_HUMAN	Homo sapiens (Human)
# POLYMORPHISM	ORNT2_HUMAN	Variant Cys-159 has a reduced ornithine transport activity, while variant Gly-181 has an increased activity. 
# PROSITE	PS50920	SOLCAR; 3
# Pfam	PF00153	Mito_carr; 3
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-70635	Urea cycle
# RecName	ORNT2_HUMAN	Mitochondrial ornithine transporter 2
# RefSeq	NP_114153	NM_031947.3
# SIMILARITY	Belongs to the mitochondrial carrier (TC 2.A.29) family. {ECO	0000305}. 
# SIMILARITY	Contains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule	PRU00282}.
# SUBCELLULAR LOCATION	ORNT2_HUMAN	Mitochondrion inner membrane; Multi-pass membrane protein. 
# SUPFAM	SSF103506	SSF103506
# TCDB	2.A.29.19	the mitochondrial carrier (mc) family
# TISSUE SPECIFICITY	ORNT2_HUMAN	Expressed in liver, kidney, pancreas and cultured fibroblasts. 
# UCSC	uc003ljf	human
# eggNOG	ENOG410XNVH	LUCA
# eggNOG	KOG0763	Eukaryota
BLAST	swissprot:ORNT2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ORNT2_HUMAN
BioCyc	ZFISH:ENSG00000120329-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000120329-MONOMER
COXPRESdb	83884	http://coxpresdb.jp/data/gene/83884.shtml
CleanEx	HS_SLC25A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC25A2
DOI	10.1016/S1096-7192(03)00105-7	http://dx.doi.org/10.1016/S1096-7192(03)00105-7
DOI	10.1101/gr.167301	http://dx.doi.org/10.1101/gr.167301
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00129	http://www.drugbank.ca/drugs/DB00129
EMBL	AF332005	http://www.ebi.ac.uk/ena/data/view/AF332005
EMBL	AF378119	http://www.ebi.ac.uk/ena/data/view/AF378119
EMBL	AY208943	http://www.ebi.ac.uk/ena/data/view/AY208943
EMBL	BC069458	http://www.ebi.ac.uk/ena/data/view/BC069458
EMBL	BC100935	http://www.ebi.ac.uk/ena/data/view/BC100935
EMBL	BC100936	http://www.ebi.ac.uk/ena/data/view/BC100936
EMBL	BC100937	http://www.ebi.ac.uk/ena/data/view/BC100937
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
Ensembl	ENST00000239451	http://www.ensembl.org/id/ENST00000239451
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0000064	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000064
GO_process	GO:0000050	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000050
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0071941	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941
Gene3D	1.50.40.10	http://www.cathdb.info/version/latest/superfamily/1.50.40.10
GeneCards	SLC25A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC25A2
GeneID	83884	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83884
GeneTree	ENSGT00730000110966	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00730000110966
HGNC	HGNC:22921	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:22921
HOGENOM	HOG000168307	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000168307&db=HOGENOM6
HOVERGEN	HBG062630	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG062630&db=HOVERGEN
HPA	HPA042146	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042146
InParanoid	Q9BXI2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9BXI2
InterPro	IPR018108	http://www.ebi.ac.uk/interpro/entry/IPR018108
InterPro	IPR023395	http://www.ebi.ac.uk/interpro/entry/IPR023395
Jabion	83884	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=83884
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:83884	http://www.genome.jp/dbget-bin/www_bget?hsa:83884
KEGG_Orthology	KO:K15101	http://www.genome.jp/dbget-bin/www_bget?KO:K15101
MIM	608157	http://www.ncbi.nlm.nih.gov/omim/608157
OMA	EYSRRMM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EYSRRMM
OrthoDB	EOG091G0HVE	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0HVE
PROSITE	PS50920	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50920
PSORT	swissprot:ORNT2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ORNT2_HUMAN
PSORT-B	swissprot:ORNT2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ORNT2_HUMAN
PSORT2	swissprot:ORNT2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ORNT2_HUMAN
Pfam	PF00153	http://pfam.xfam.org/family/PF00153
PharmGKB	PA134910073	http://www.pharmgkb.org/do/serve?objId=PA134910073&objCls=Gene
Phobius	swissprot:ORNT2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ORNT2_HUMAN
PhylomeDB	Q9BXI2	http://phylomedb.org/?seqid=Q9BXI2
ProteinModelPortal	Q9BXI2	http://www.proteinmodelportal.org/query/uniprot/Q9BXI2
PubMed	11230163	http://www.ncbi.nlm.nih.gov/pubmed/11230163
PubMed	12948741	http://www.ncbi.nlm.nih.gov/pubmed/12948741
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-70635	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-70635
RefSeq	NP_114153	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_114153
STRING	9606.ENSP00000239451	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000239451&targetmode=cogs
SUPFAM	SSF103506	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103506
TCDB	2.A.29.19	http://www.tcdb.org/search/result.php?tc=2.A.29.19
UCSC	uc003ljf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ljf&org=rat
UniGene	Hs.97647	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.97647
UniProtKB	ORNT2_HUMAN	http://www.uniprot.org/uniprot/ORNT2_HUMAN
UniProtKB-AC	Q9BXI2	http://www.uniprot.org/uniprot/Q9BXI2
charge	swissprot:ORNT2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ORNT2_HUMAN
eggNOG	ENOG410XNVH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNVH
eggNOG	KOG0763	http://eggnogapi.embl.de/nog_data/html/tree/KOG0763
epestfind	swissprot:ORNT2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ORNT2_HUMAN
garnier	swissprot:ORNT2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ORNT2_HUMAN
helixturnhelix	swissprot:ORNT2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ORNT2_HUMAN
hmoment	swissprot:ORNT2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ORNT2_HUMAN
iep	swissprot:ORNT2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ORNT2_HUMAN
inforesidue	swissprot:ORNT2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ORNT2_HUMAN
neXtProt	NX_Q9BXI2	http://www.nextprot.org/db/entry/NX_Q9BXI2
octanol	swissprot:ORNT2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ORNT2_HUMAN
pepcoil	swissprot:ORNT2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ORNT2_HUMAN
pepdigest	swissprot:ORNT2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ORNT2_HUMAN
pepinfo	swissprot:ORNT2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ORNT2_HUMAN
pepnet	swissprot:ORNT2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ORNT2_HUMAN
pepstats	swissprot:ORNT2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ORNT2_HUMAN
pepwheel	swissprot:ORNT2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ORNT2_HUMAN
pepwindow	swissprot:ORNT2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ORNT2_HUMAN
sigcleave	swissprot:ORNT2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ORNT2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ABCG2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UNQ0-1; Sequence=Displayed; Name=2; IsoId=Q9UNQ0-2; Sequence=VSP_014232, VSP_014233; Note=No experimental confirmation available.; 
# AltName	ABCG2_HUMAN	Breast cancer resistance protein
# AltName	ABCG2_HUMAN	CD338
# AltName	ABCG2_HUMAN	CDw338
# AltName	ABCG2_HUMAN	Mitoxantrone resistance-associated protein
# AltName	ABCG2_HUMAN	Placenta-specific ATP-binding cassette transporter
# AltName	ABCG2_HUMAN	Urate exporter
# BioGrid	114821	17
# CCDS	CCDS3628	-. [Q9UNQ0-1]
# CCDS	CCDS58910	-. [Q9UNQ0-2]
# ChiTaRS	ABCG2	human
# DOMAIN	ABCG2_HUMAN	The extracellular loop 3 (ECL3) is involved in binding porphyrins and transfer them to other carriers, probably albumin. {ECO 0000269|PubMed 20705604}. 
# DrugBank	DB00091	Cyclosporine
# DrugBank	DB00158	Folic Acid
# DrugBank	DB00175	Pravastatin
# DrugBank	DB00213	Pantoprazole
# DrugBank	DB00220	Nelfinavir
# DrugBank	DB00242	Cladribine
# DrugBank	DB00255	Diethylstilbestrol
# DrugBank	DB00285	Venlafaxine
# DrugBank	DB00286	Conjugated Estrogens
# DrugBank	DB00317	Gefitinib
# DrugBank	DB00338	Omeprazole
# DrugBank	DB00398	Sorafenib
# DrugBank	DB00444	Teniposide
# DrugBank	DB00448	Lansoprazole
# DrugBank	DB00457	Prazosin
# DrugBank	DB00470	Dronabinol
# DrugBank	DB00495	Zidovudine
# DrugBank	DB00503	Ritonavir
# DrugBank	DB00515	Cisplatin
# DrugBank	DB00526	Oxaliplatin
# DrugBank	DB00530	Erlotinib
# DrugBank	DB00541	Vincristine
# DrugBank	DB00544	Fluorouracil
# DrugBank	DB00549	Zafirlukast
# DrugBank	DB00563	Methotrexate
# DrugBank	DB00602	Ivermectin
# DrugBank	DB00619	Imatinib
# DrugBank	DB00624	Testosterone
# DrugBank	DB00631	Clofarabine
# DrugBank	DB00655	Estrone
# DrugBank	DB00661	Verapamil
# DrugBank	DB00669	Sumatriptan
# DrugBank	DB00675	Tamoxifen
# DrugBank	DB00688	Mycophenolate mofetil
# DrugBank	DB00694	Daunorubicin
# DrugBank	DB00698	Nitrofurantoin
# DrugBank	DB00709	Lamivudine
# DrugBank	DB00740	Riluzole
# DrugBank	DB00741	Hydrocortisone
# DrugBank	DB00762	Irinotecan
# DrugBank	DB00773	Etoposide
# DrugBank	DB00783	Estradiol
# DrugBank	DB00795	Sulfasalazine
# DrugBank	DB00921	Buprenorphine
# DrugBank	DB00958	Carboplatin
# DrugBank	DB00966	Telmisartan
# DrugBank	DB00970	Dactinomycin
# DrugBank	DB00973	Ezetimibe
# DrugBank	DB00997	Doxorubicin
# DrugBank	DB01016	Glyburide
# DrugBank	DB01030	Topotecan
# DrugBank	DB01051	Novobiocin
# DrugBank	DB01094	Hesperetin
# DrugBank	DB01097	Leflunomide
# DrugBank	DB01098	Rosuvastatin
# DrugBank	DB01129	Rabeprazole
# DrugBank	DB01204	Mitoxantrone
# DrugBank	DB01229	Paclitaxel
# DrugBank	DB01232	Saquinavir
# DrugBank	DB01234	Dexamethasone
# DrugBank	DB01248	Docetaxel
# DrugBank	DB01254	Dasatinib
# DrugBank	DB01268	Sunitinib
# DrugBank	DB04868	Nilotinib
# DrugBank	DB05239	Cobimetinib
# DrugBank	DB05294	Vandetanib
# DrugBank	DB06589	Pazopanib
# DrugBank	DB06605	Apixaban
# DrugBank	DB06772	Cabazitaxel
# DrugBank	DB08828	Vismodegib
# DrugBank	DB08860	Pitavastatin
# DrugBank	DB08864	Rilpivirine
# DrugBank	DB08880	Teriflunomide
# DrugBank	DB08881	Vemurafenib
# DrugBank	DB08896	Regorafenib
# DrugBank	DB08901	Ponatinib
# DrugBank	DB08912	Dabrafenib
# DrugBank	DB08916	Afatinib
# DrugBank	DB08931	Riociguat
# DrugBank	DB08934	Sofosbuvir
# DrugBank	DB09054	Idelalisib
# DrugBank	DB09065	Cobicistat
# DrugBank	DB09078	Lenvatinib
# DrugBank	DB09102	Daclatasvir
# DrugBank	DB09291	Rolapitant
# DrugBank	DB09330	Osimertinib
# DrugBank	DB11363	Alectinib
# Ensembl	ENST00000237612	ENSP00000237612; ENSG00000118777. [Q9UNQ0-1]
# Ensembl	ENST00000515655	ENSP00000426917; ENSG00000118777. [Q9UNQ0-2]
# ExpressionAtlas	Q9UNQ0	baseline and differential
# FUNCTION	ABCG2_HUMAN	High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics  mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin. {ECO 0000269|PubMed 12958161, ECO 0000269|PubMed 20705604, ECO 0000269|PubMed 22132962, ECO 0000269|PubMed 23189181}. 
# GO_component	GO:0005634	nucleus; IDA:HPA.
# GO_component	GO:0005886	plasma membrane; IDA:HPA.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_component	GO:0031966	mitochondrial membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0005215	transporter activity; TAS:ProtInc.
# GO_function	GO:0005524	ATP binding; TAS:ProtInc.
# GO_function	GO:0008559	xenobiotic-transporting ATPase activity; TAS:ProtInc.
# GO_function	GO:0015232	heme transporter activity; TAS:Reactome.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; TAS:ProtInc.
# GO_function	GO:0042803	protein homodimerization activity; IDA:BHF-UCL.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006879	cellular iron ion homeostasis; TAS:Reactome.
# GO_process	GO:0042493	response to drug; TAS:ProtInc.
# GO_process	GO:0046415	urate metabolic process; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044281	small molecule metabolic process
# Gene3D	3.40.50.300	-; 1.
# Genevisible	Q9UNQ0	HS
# HGNC	HGNC:74	ABCG2
# INDUCTION	ABCG2_HUMAN	Up-regulated in brain tumors. 
# INTERACTION	ABCG2_HUMAN	P11309-1 PIM1; NbExp=9; IntAct=EBI-1569435, EBI-1018629; P0CG48 UBC; NbExp=2; IntAct=EBI-1569435, EBI-3390054; 
# IntAct	Q9UNQ0	19
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR013525	ABC_2_trans
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Brite	ko04090	 Cellular antigens
# KEGG_Pathway	ko02010	ABC transporters
# KEGG_Pathway	ko04976	Bile secretion
# MIM	138900	phenotype
# MIM	603756	gene
# MIM	614490	phenotype
# MISCELLANEOUS	ABCG2_HUMAN	When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin. 
# Organism	ABCG2_HUMAN	Homo sapiens (Human)
# POLYMORPHISM	ABCG2_HUMAN	Genetic variations in ABCG2 define the blood group Junior system (JR) [MIM 614490]. Individuals with Jr(a-) blood group lack the Jr(a) antigen on their red blood cells. These individuals may have anti-Jr(a) antibodies in their serum, which can cause transfusion reactions or hemolytic disease of the fetus or newborn. Although the clinical significance of the Jr(a-) blood group has been controversial, severe fatal hemolytic disease of the newborn has been reported. The Jr(a-) phenotype has a higher frequency in individuals of Asian descent, compared to those of European descent. The Jr(a-) phenotype is inherited as an autosomal recessive trait. {ECO 0000269|PubMed 22246505, ECO 0000269|PubMed 22246507}. 
# POLYMORPHISM	ABCG2_HUMAN	Genetic variations in ABCG2 influence the variance in serum uric acid concentrations and define the serum uric acid concentration quantitative trait locus 1 (UAQTL1) [MIM 138900]. Excess serum accumulation of uric acid can lead to the development of gout, a common disorder characterized by tissue deposition of monosodium urate crystals as a consequence of hyperuricemia (PubMed 18834626, PubMed 19506252, PubMed 20368174). {ECO 0000269|PubMed 18834626, ECO 0000269|PubMed 19506252, ECO 0000269|PubMed 20368174}. 
# PROSITE	PS50893	ABC_TRANSPORTER_2
# PTM	ABCG2_HUMAN	Glycosylation-deficient ABCG2 is normally expressed and functional. {ECO 0000269|PubMed 15807535}. 
# Pfam	PF00005	ABC_tran
# Pfam	PF01061	ABC2_membrane
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-2161517	Abacavir transmembrane transport
# Reactome	R-HSA-917937	Iron uptake and transport
# RecName	ABCG2_HUMAN	ATP-binding cassette sub-family G member 2
# RefSeq	NP_001244315	NM_001257386.1. [Q9UNQ0-2]
# RefSeq	NP_004818	NM_004827.2. [Q9UNQ0-1]
# RefSeq	XP_005263411	XM_005263354.3. [Q9UNQ0-1]
# RefSeq	XP_005263412	XM_005263355.3. [Q9UNQ0-1]
# RefSeq	XP_011530722	XM_011532420.2. [Q9UNQ0-1]
# RefSeq	XP_016864342	XM_017008853.1. [Q9UNQ0-1]
# SEQUENCE CAUTION	Sequence=AF093771; Type=Frameshift; Positions=486, 586; Evidence={ECO:0000305}; Sequence=AF093772; Type=Frameshift; Positions=386, 502, 586; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 ABC transmembrane type-2 domain. {ECO	0000305}. 
# SIMILARITY	Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA
# SUBCELLULAR LOCATION	ABCG2_HUMAN	Cell membrane {ECO 0000269|PubMed 15001581, ECO 0000269|PubMed 15769853, ECO 0000269|PubMed 15807535}; Multi- pass membrane protein {ECO 0000255}. Mitochondrion membrane {ECO 0000269|PubMed 23189181}; Multi-pass membrane protein {ECO 0000255}. 
# SUBUNIT	ABCG2_HUMAN	Monomer under reducing conditions, the minimal functional units is a homodimer; disulfide-linked, but the major oligomeric form in plasma membranes is a homotetramer with possibility of higher order oligomerization up to homododecamers. {ECO 0000269|PubMed 15001581, ECO 0000269|PubMed 17686774}. 
# SUPFAM	SSF52540	SSF52540
# TCDB	3.A.1.204	the atp-binding cassette (abc) superfamily
# TISSUE SPECIFICITY	ABCG2_HUMAN	Highly expressed in placenta. Low expression in small intestine, liver and colon. {ECO 0000269|PubMed 9850061, ECO 0000269|PubMed 9861027}. 
# UCSC	uc003hrg	human. [Q9UNQ0-1]
# WEB RESOURCE	ABCG2_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=Q9UNQ0";
# WEB RESOURCE	ABCG2_HUMAN	Name=SeattleSNPs; URL="http //pga.gs.washington.edu/data/abcg2/"; 
# eggNOG	COG0842	LUCA
# eggNOG	ENOG410IN8P	Eukaryota
BLAST	swissprot:ABCG2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCG2_HUMAN
BioCyc	ZFISH:ENSG00000118777-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000118777-MONOMER
COXPRESdb	9429	http://coxpresdb.jp/data/gene/9429.shtml
DIP	DIP-29162N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29162N
DOI	10.1007/s00280-004-0931-x	http://dx.doi.org/10.1007/s00280-004-0931-x
DOI	10.1007/s100380200041	http://dx.doi.org/10.1007/s100380200041
DOI	10.1016/S0140-6736(08)61343-4	http://dx.doi.org/10.1016/S0140-6736(08)61343-4
DOI	10.1016/j.bbamem.2004.11.005	http://dx.doi.org/10.1016/j.bbamem.2004.11.005
DOI	10.1021/bi0479858	http://dx.doi.org/10.1021/bi0479858
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng.1070	http://dx.doi.org/10.1038/ng.1070
DOI	10.1038/ng.1075	http://dx.doi.org/10.1038/ng.1075
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/nm0901-1028	http://dx.doi.org/10.1038/nm0901-1028
DOI	10.1073/pnas.0901249106	http://dx.doi.org/10.1073/pnas.0901249106
DOI	10.1073/pnas.95.26.15665	http://dx.doi.org/10.1073/pnas.95.26.15665
DOI	10.1074/jbc.C700133200	http://dx.doi.org/10.1074/jbc.C700133200
DOI	10.1074/jbc.M110.139170	http://dx.doi.org/10.1074/jbc.M110.139170
DOI	10.1074/jbc.M310785200	http://dx.doi.org/10.1074/jbc.M310785200
DOI	10.1080/15257770.2011.633953	http://dx.doi.org/10.1080/15257770.2011.633953
DOI	10.1096/fj.02-1131fje	http://dx.doi.org/10.1096/fj.02-1131fje
DOI	10.1097/00008571-200301000-00004	http://dx.doi.org/10.1097/00008571-200301000-00004
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scitranslmed.3000237	http://dx.doi.org/10.1126/scitranslmed.3000237
DOI	10.1242/jcs.01729	http://dx.doi.org/10.1242/jcs.01729
DOI	10.1371/journal.pone.0050082	http://dx.doi.org/10.1371/journal.pone.0050082
DOI	10.2133/dmpk.18.212	http://dx.doi.org/10.2133/dmpk.18.212
DOI	10.2133/dmpk.21.109	http://dx.doi.org/10.2133/dmpk.21.109
DrugBank	DB00091	http://www.drugbank.ca/drugs/DB00091
DrugBank	DB00158	http://www.drugbank.ca/drugs/DB00158
DrugBank	DB00175	http://www.drugbank.ca/drugs/DB00175
DrugBank	DB00213	http://www.drugbank.ca/drugs/DB00213
DrugBank	DB00220	http://www.drugbank.ca/drugs/DB00220
DrugBank	DB00242	http://www.drugbank.ca/drugs/DB00242
DrugBank	DB00255	http://www.drugbank.ca/drugs/DB00255
DrugBank	DB00285	http://www.drugbank.ca/drugs/DB00285
DrugBank	DB00286	http://www.drugbank.ca/drugs/DB00286
DrugBank	DB00317	http://www.drugbank.ca/drugs/DB00317
DrugBank	DB00338	http://www.drugbank.ca/drugs/DB00338
DrugBank	DB00398	http://www.drugbank.ca/drugs/DB00398
DrugBank	DB00444	http://www.drugbank.ca/drugs/DB00444
DrugBank	DB00448	http://www.drugbank.ca/drugs/DB00448
DrugBank	DB00457	http://www.drugbank.ca/drugs/DB00457
DrugBank	DB00470	http://www.drugbank.ca/drugs/DB00470
DrugBank	DB00495	http://www.drugbank.ca/drugs/DB00495
DrugBank	DB00503	http://www.drugbank.ca/drugs/DB00503
DrugBank	DB00515	http://www.drugbank.ca/drugs/DB00515
DrugBank	DB00526	http://www.drugbank.ca/drugs/DB00526
DrugBank	DB00530	http://www.drugbank.ca/drugs/DB00530
DrugBank	DB00541	http://www.drugbank.ca/drugs/DB00541
DrugBank	DB00544	http://www.drugbank.ca/drugs/DB00544
DrugBank	DB00549	http://www.drugbank.ca/drugs/DB00549
DrugBank	DB00563	http://www.drugbank.ca/drugs/DB00563
DrugBank	DB00602	http://www.drugbank.ca/drugs/DB00602
DrugBank	DB00619	http://www.drugbank.ca/drugs/DB00619
DrugBank	DB00624	http://www.drugbank.ca/drugs/DB00624
DrugBank	DB00631	http://www.drugbank.ca/drugs/DB00631
DrugBank	DB00655	http://www.drugbank.ca/drugs/DB00655
DrugBank	DB00661	http://www.drugbank.ca/drugs/DB00661
DrugBank	DB00669	http://www.drugbank.ca/drugs/DB00669
DrugBank	DB00675	http://www.drugbank.ca/drugs/DB00675
DrugBank	DB00688	http://www.drugbank.ca/drugs/DB00688
DrugBank	DB00694	http://www.drugbank.ca/drugs/DB00694
DrugBank	DB00698	http://www.drugbank.ca/drugs/DB00698
DrugBank	DB00709	http://www.drugbank.ca/drugs/DB00709
DrugBank	DB00740	http://www.drugbank.ca/drugs/DB00740
DrugBank	DB00741	http://www.drugbank.ca/drugs/DB00741
DrugBank	DB00762	http://www.drugbank.ca/drugs/DB00762
DrugBank	DB00773	http://www.drugbank.ca/drugs/DB00773
DrugBank	DB00783	http://www.drugbank.ca/drugs/DB00783
DrugBank	DB00795	http://www.drugbank.ca/drugs/DB00795
DrugBank	DB00921	http://www.drugbank.ca/drugs/DB00921
DrugBank	DB00958	http://www.drugbank.ca/drugs/DB00958
DrugBank	DB00966	http://www.drugbank.ca/drugs/DB00966
DrugBank	DB00970	http://www.drugbank.ca/drugs/DB00970
DrugBank	DB00973	http://www.drugbank.ca/drugs/DB00973
DrugBank	DB00997	http://www.drugbank.ca/drugs/DB00997
DrugBank	DB01016	http://www.drugbank.ca/drugs/DB01016
DrugBank	DB01030	http://www.drugbank.ca/drugs/DB01030
DrugBank	DB01051	http://www.drugbank.ca/drugs/DB01051
DrugBank	DB01094	http://www.drugbank.ca/drugs/DB01094
DrugBank	DB01097	http://www.drugbank.ca/drugs/DB01097
DrugBank	DB01098	http://www.drugbank.ca/drugs/DB01098
DrugBank	DB01129	http://www.drugbank.ca/drugs/DB01129
DrugBank	DB01204	http://www.drugbank.ca/drugs/DB01204
DrugBank	DB01229	http://www.drugbank.ca/drugs/DB01229
DrugBank	DB01232	http://www.drugbank.ca/drugs/DB01232
DrugBank	DB01234	http://www.drugbank.ca/drugs/DB01234
DrugBank	DB01248	http://www.drugbank.ca/drugs/DB01248
DrugBank	DB01254	http://www.drugbank.ca/drugs/DB01254
DrugBank	DB01268	http://www.drugbank.ca/drugs/DB01268
DrugBank	DB04868	http://www.drugbank.ca/drugs/DB04868
DrugBank	DB05239	http://www.drugbank.ca/drugs/DB05239
DrugBank	DB05294	http://www.drugbank.ca/drugs/DB05294
DrugBank	DB06589	http://www.drugbank.ca/drugs/DB06589
DrugBank	DB06605	http://www.drugbank.ca/drugs/DB06605
DrugBank	DB06772	http://www.drugbank.ca/drugs/DB06772
DrugBank	DB08828	http://www.drugbank.ca/drugs/DB08828
DrugBank	DB08860	http://www.drugbank.ca/drugs/DB08860
DrugBank	DB08864	http://www.drugbank.ca/drugs/DB08864
DrugBank	DB08880	http://www.drugbank.ca/drugs/DB08880
DrugBank	DB08881	http://www.drugbank.ca/drugs/DB08881
DrugBank	DB08896	http://www.drugbank.ca/drugs/DB08896
DrugBank	DB08901	http://www.drugbank.ca/drugs/DB08901
DrugBank	DB08912	http://www.drugbank.ca/drugs/DB08912
DrugBank	DB08916	http://www.drugbank.ca/drugs/DB08916
DrugBank	DB08931	http://www.drugbank.ca/drugs/DB08931
DrugBank	DB08934	http://www.drugbank.ca/drugs/DB08934
DrugBank	DB09054	http://www.drugbank.ca/drugs/DB09054
DrugBank	DB09065	http://www.drugbank.ca/drugs/DB09065
DrugBank	DB09078	http://www.drugbank.ca/drugs/DB09078
DrugBank	DB09102	http://www.drugbank.ca/drugs/DB09102
DrugBank	DB09291	http://www.drugbank.ca/drugs/DB09291
DrugBank	DB09330	http://www.drugbank.ca/drugs/DB09330
DrugBank	DB11363	http://www.drugbank.ca/drugs/DB11363
EMBL	AB051855	http://www.ebi.ac.uk/ena/data/view/AB051855
EMBL	AB056867	http://www.ebi.ac.uk/ena/data/view/AB056867
EMBL	AC084732	http://www.ebi.ac.uk/ena/data/view/AC084732
EMBL	AC097484	http://www.ebi.ac.uk/ena/data/view/AC097484
EMBL	AF093771	http://www.ebi.ac.uk/ena/data/view/AF093771
EMBL	AF093772	http://www.ebi.ac.uk/ena/data/view/AF093772
EMBL	AF098951	http://www.ebi.ac.uk/ena/data/view/AF098951
EMBL	AF103796	http://www.ebi.ac.uk/ena/data/view/AF103796
EMBL	AF463519	http://www.ebi.ac.uk/ena/data/view/AF463519
EMBL	AK002040	http://www.ebi.ac.uk/ena/data/view/AK002040
EMBL	AK290000	http://www.ebi.ac.uk/ena/data/view/AK290000
EMBL	AY017168	http://www.ebi.ac.uk/ena/data/view/AY017168
EMBL	AY288307	http://www.ebi.ac.uk/ena/data/view/AY288307
EMBL	AY289766	http://www.ebi.ac.uk/ena/data/view/AY289766
EMBL	AY333755	http://www.ebi.ac.uk/ena/data/view/AY333755
EMBL	AY333756	http://www.ebi.ac.uk/ena/data/view/AY333756
EMBL	BC021281	http://www.ebi.ac.uk/ena/data/view/BC021281
EMBL	BC092408	http://www.ebi.ac.uk/ena/data/view/BC092408
EMBL	DQ996467	http://www.ebi.ac.uk/ena/data/view/DQ996467
Ensembl	ENST00000237612	http://www.ensembl.org/id/ENST00000237612
Ensembl	ENST00000515655	http://www.ensembl.org/id/ENST00000515655
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0031966	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031966
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0008559	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008559
GO_function	GO:0015232	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015232
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006879	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006879
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0046415	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046415
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCG2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCG2
GeneID	9429	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9429
GeneTree	ENSGT00740000114855	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00740000114855
HGNC	HGNC:74	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:74
HOVERGEN	HBG050441	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050441&db=HOVERGEN
HPA	CAB037299	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB037299
HPA	HPA054719	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA054719
InParanoid	Q9UNQ0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UNQ0
IntAct	Q9UNQ0	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9UNQ0*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR013525	http://www.ebi.ac.uk/interpro/entry/IPR013525
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	9429	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9429
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko04090	http://www.genome.jp/dbget-bin/www_bget?ko04090
KEGG_Gene	hsa:9429	http://www.genome.jp/dbget-bin/www_bget?hsa:9429
KEGG_Orthology	KO:K05681	http://www.genome.jp/dbget-bin/www_bget?KO:K05681
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
MIM	138900	http://www.ncbi.nlm.nih.gov/omim/138900
MIM	603756	http://www.ncbi.nlm.nih.gov/omim/603756
MIM	614490	http://www.ncbi.nlm.nih.gov/omim/614490
MINT	MINT-2840423	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-2840423
OMA	VDSSFYK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VDSSFYK
OrthoDB	EOG091G08QB	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08QB
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PSORT	swissprot:ABCG2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCG2_HUMAN
PSORT-B	swissprot:ABCG2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCG2_HUMAN
PSORT2	swissprot:ABCG2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCG2_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF01061	http://pfam.xfam.org/family/PF01061
PharmGKB	PA390	http://www.pharmgkb.org/do/serve?objId=PA390&objCls=Gene
Phobius	swissprot:ABCG2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCG2_HUMAN
PhylomeDB	Q9UNQ0	http://phylomedb.org/?seqid=Q9UNQ0
ProteinModelPortal	Q9UNQ0	http://www.proteinmodelportal.org/query/uniprot/Q9UNQ0
PubMed	11306452	http://www.ncbi.nlm.nih.gov/pubmed/11306452
PubMed	11533706	http://www.ncbi.nlm.nih.gov/pubmed/11533706
PubMed	11590207	http://www.ncbi.nlm.nih.gov/pubmed/11590207
PubMed	12111378	http://www.ncbi.nlm.nih.gov/pubmed/12111378
PubMed	12544509	http://www.ncbi.nlm.nih.gov/pubmed/12544509
PubMed	12958161	http://www.ncbi.nlm.nih.gov/pubmed/12958161
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15001581	http://www.ncbi.nlm.nih.gov/pubmed/15001581
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15618737	http://www.ncbi.nlm.nih.gov/pubmed/15618737
PubMed	15670731	http://www.ncbi.nlm.nih.gov/pubmed/15670731
PubMed	15769853	http://www.ncbi.nlm.nih.gov/pubmed/15769853
PubMed	15807535	http://www.ncbi.nlm.nih.gov/pubmed/15807535
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	15838659	http://www.ncbi.nlm.nih.gov/pubmed/15838659
PubMed	16702730	http://www.ncbi.nlm.nih.gov/pubmed/16702730
PubMed	17686774	http://www.ncbi.nlm.nih.gov/pubmed/17686774
PubMed	18834626	http://www.ncbi.nlm.nih.gov/pubmed/18834626
PubMed	19506252	http://www.ncbi.nlm.nih.gov/pubmed/19506252
PubMed	20368174	http://www.ncbi.nlm.nih.gov/pubmed/20368174
PubMed	20705604	http://www.ncbi.nlm.nih.gov/pubmed/20705604
PubMed	22132962	http://www.ncbi.nlm.nih.gov/pubmed/22132962
PubMed	22246505	http://www.ncbi.nlm.nih.gov/pubmed/22246505
PubMed	22246507	http://www.ncbi.nlm.nih.gov/pubmed/22246507
PubMed	22509477	http://www.ncbi.nlm.nih.gov/pubmed/22509477
PubMed	23189181	http://www.ncbi.nlm.nih.gov/pubmed/23189181
PubMed	9850061	http://www.ncbi.nlm.nih.gov/pubmed/9850061
PubMed	9861027	http://www.ncbi.nlm.nih.gov/pubmed/9861027
PubMed	9892175	http://www.ncbi.nlm.nih.gov/pubmed/9892175
Reactome	R-HSA-2161517	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2161517
Reactome	R-HSA-917937	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917937
RefSeq	NP_001244315	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001244315
RefSeq	NP_004818	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004818
RefSeq	XP_005263411	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005263411
RefSeq	XP_005263412	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005263412
RefSeq	XP_011530722	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011530722
RefSeq	XP_016864342	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016864342
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
STRING	9606.ENSP00000237612	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000237612&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TCDB	3.A.1.204	http://www.tcdb.org/search/result.php?tc=3.A.1.204
UCSC	uc003hrg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003hrg&org=rat
UniGene	Hs.480218	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.480218
UniProtKB	ABCG2_HUMAN	http://www.uniprot.org/uniprot/ABCG2_HUMAN
UniProtKB-AC	Q9UNQ0	http://www.uniprot.org/uniprot/Q9UNQ0
charge	swissprot:ABCG2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCG2_HUMAN
eggNOG	COG0842	http://eggnogapi.embl.de/nog_data/html/tree/COG0842
eggNOG	ENOG410IN8P	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IN8P
epestfind	swissprot:ABCG2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCG2_HUMAN
garnier	swissprot:ABCG2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCG2_HUMAN
helixturnhelix	swissprot:ABCG2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCG2_HUMAN
hmoment	swissprot:ABCG2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCG2_HUMAN
iep	swissprot:ABCG2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCG2_HUMAN
inforesidue	swissprot:ABCG2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCG2_HUMAN
neXtProt	NX_Q9UNQ0	http://www.nextprot.org/db/entry/NX_Q9UNQ0
octanol	swissprot:ABCG2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCG2_HUMAN
pepcoil	swissprot:ABCG2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCG2_HUMAN
pepdigest	swissprot:ABCG2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCG2_HUMAN
pepinfo	swissprot:ABCG2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCG2_HUMAN
pepnet	swissprot:ABCG2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCG2_HUMAN
pepstats	swissprot:ABCG2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCG2_HUMAN
pepwheel	swissprot:ABCG2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCG2_HUMAN
pepwindow	swissprot:ABCG2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCG2_HUMAN
sigcleave	swissprot:ABCG2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCG2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing, Alternative initiation; Named isoforms=3; Comment=A number of isoforms are produced by alternative initiation. Isoforms start at multiple alternative CUG and GUG codons. {ECO:0000269|PubMed	11350958}; Name=1; IsoId=Q15758-1; Sequence=Displayed; Name=2; IsoId=Q15758-2; Sequence=VSP_046354; Note=No experimental confirmation available.; Name=3; IsoId=Q15758-3; Sequence=VSP_046851; Note=No experimental confirmation available.; 
# AltName	AAAT_HUMAN	Baboon M7 virus receptor
# AltName	AAAT_HUMAN	RD114/simian type D retrovirus receptor
# AltName	AAAT_HUMAN	Sodium-dependent neutral amino acid transporter type 2
# AltName	AAAT_HUMAN	Solute carrier family 1 member 5
# BioGrid	112401	60
# CCDS	CCDS12692	-. [Q15758-1]
# CCDS	CCDS46125	-. [Q15758-2]
# CCDS	CCDS46126	-. [Q15758-3]
# ChiTaRS	SLC1A5	human
# DrugBank	DB00130	L-Glutamine
# DrugBank	DB00174	L-Asparagine
# Ensembl	ENST00000412532	ENSP00000397924; ENSG00000105281. [Q15758-3]
# Ensembl	ENST00000434726	ENSP00000406532; ENSG00000105281. [Q15758-2]
# Ensembl	ENST00000542575	ENSP00000444408; ENSG00000105281. [Q15758-1]
# ExpressionAtlas	Q15758	baseline and differential
# FUNCTION	AAAT_HUMAN	(Microbial infection) Acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses. {ECO 0000269|PubMed 10051606, ECO 0000269|PubMed 10196349}. 
# FUNCTION	AAAT_HUMAN	Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids (PubMed 8702519). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed 10708449, PubMed 23492904). {ECO 0000269|PubMed 10708449, ECO 0000269|PubMed 23492904, ECO 0000269|PubMed 8702519}. 
# GO_component	GO:0005794	Golgi apparatus; IDA:HPA.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0042470	melanosome; IEA:UniProtKB-SubCell.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0001618	virus receptor activity; IEA:UniProtKB-KW.
# GO_function	GO:0004872	receptor activity; TAS:ProtInc.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015175	neutral amino acid transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0015186	L-glutamine transmembrane transporter activity; TAS:BHF-UCL.
# GO_function	GO:0015194	L-serine transmembrane transporter activity; IEA:Ensembl.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_process	GO:0006860	extracellular amino acid transport; IEA:Ensembl.
# GO_process	GO:0006865	amino acid transport; TAS:Reactome.
# GO_process	GO:0006868	glutamine transport; TAS:BHF-UCL.
# GO_process	GO:0015804	neutral amino acid transport; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Gene3D	1.10.3860.10	-; 1.
# Genevisible	Q15758	HS
# HGNC	HGNC:10943	SLC1A5
# INTERACTION	AAAT_HUMAN	Q99942 RNF5; NbExp=4; IntAct=EBI-356576, EBI-348482; 
# IntAct	Q15758	38
# InterPro	IPR001991	Na-dicarboxylate_symporter
# InterPro	IPR018107	Na-dicarboxylate_symporter_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04974	Protein digestion and absorption
# MIM	109190	gene
# Organism	AAAT_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11958	PTHR11958
# PRINTS	PR00173	EDTRNSPORT
# PROSITE	PS00713	NA_DICARBOXYL_SYMP_1
# PROSITE	PS00714	NA_DICARBOXYL_SYMP_2
# Pfam	PF00375	SDF
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-352230	Amino acid transport across the plasma membrane
# RecName	AAAT_HUMAN	Neutral amino acid transporter B(0)
# RefSeq	NP_001138616	NM_001145144.1. [Q15758-3]
# RefSeq	NP_001138617	NM_001145145.1. [Q15758-2]
# RefSeq	NP_005619	NM_005628.2. [Q15758-1]
# SIMILARITY	Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A5 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	AAAT_HUMAN	Cell membrane {ECO 0000269|PubMed 8702519}; Multi-pass membrane protein {ECO 0000305}. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. 
# SUBUNIT	Interacts with ERVH48-1/suppressyn; may negatively regulate syncytialization. {ECO:0000269|PubMed	23492904}. 
# SUPFAM	SSF118215	SSF118215
# TCDB	2.A.23.3:the dicarboxylate/amino acid	cation (na(+) or h(+)) symporter (daacs) family
# TISSUE SPECIFICITY	AAAT_HUMAN	Placenta, lung, skeletal muscle, kidney, pancreas, and intestine. 
# UCSC	uc002pfr	human. [Q15758-1]
# eggNOG	COG1301	LUCA
# eggNOG	KOG3787	Eukaryota
BLAST	swissprot:AAAT_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AAAT_HUMAN
BioCyc	ZFISH:ENSG00000105281-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000105281-MONOMER
COXPRESdb	6510	http://coxpresdb.jp/data/gene/6510.shtml
CleanEx	HS_SLC1A5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC1A5
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr060363j	http://dx.doi.org/10.1021/pr060363j
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DOI	10.1038/nbt.1532	http://dx.doi.org/10.1038/nbt.1532
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/srep01462	http://dx.doi.org/10.1038/srep01462
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1073/pnas.96.5.2129	http://dx.doi.org/10.1073/pnas.96.5.2129
DOI	10.1074/jbc.271.31.18657	http://dx.doi.org/10.1074/jbc.271.31.18657
DOI	10.1074/jbc.M100737200	http://dx.doi.org/10.1074/jbc.M100737200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1128/JVI.74.7.3321-3329.2000	http://dx.doi.org/10.1128/JVI.74.7.3321-3329.2000
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DrugBank	DB00130	http://www.drugbank.ca/drugs/DB00130
DrugBank	DB00174	http://www.drugbank.ca/drugs/DB00174
EMBL	AC008622	http://www.ebi.ac.uk/ena/data/view/AC008622
EMBL	AF102826	http://www.ebi.ac.uk/ena/data/view/AF102826
EMBL	AF105423	http://www.ebi.ac.uk/ena/data/view/AF105423
EMBL	AF334818	http://www.ebi.ac.uk/ena/data/view/AF334818
EMBL	AK292690	http://www.ebi.ac.uk/ena/data/view/AK292690
EMBL	AK299137	http://www.ebi.ac.uk/ena/data/view/AK299137
EMBL	AK301661	http://www.ebi.ac.uk/ena/data/view/AK301661
EMBL	AK316546	http://www.ebi.ac.uk/ena/data/view/AK316546
EMBL	BC000062	http://www.ebi.ac.uk/ena/data/view/BC000062
EMBL	CH471126	http://www.ebi.ac.uk/ena/data/view/CH471126
EMBL	GQ919058	http://www.ebi.ac.uk/ena/data/view/GQ919058
EMBL	U53347	http://www.ebi.ac.uk/ena/data/view/U53347
Ensembl	ENST00000412532	http://www.ensembl.org/id/ENST00000412532
Ensembl	ENST00000434726	http://www.ensembl.org/id/ENST00000434726
Ensembl	ENST00000542575	http://www.ensembl.org/id/ENST00000542575
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0042470	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042470
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0001618	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001618
GO_function	GO:0004872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004872
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_function	GO:0015175	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015175
GO_function	GO:0015186	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015186
GO_function	GO:0015194	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015194
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_process	GO:0006860	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006860
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GO_process	GO:0006868	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006868
GO_process	GO:0015804	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015804
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
Gene3D	1.10.3860.10	http://www.cathdb.info/version/latest/superfamily/1.10.3860.10
GeneCards	SLC1A5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC1A5
GeneID	6510	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6510
GeneTree	ENSGT00760000119117	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119117
H-InvDB	HIX0015262	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0015262
HGNC	HGNC:10943	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10943
HOGENOM	HOG000208776	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000208776&db=HOGENOM6
HOVERGEN	HBG000080	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000080&db=HOVERGEN
HPA	HPA035239	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035239
HPA	HPA035240	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035240
InParanoid	Q15758	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q15758
IntAct	Q15758	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q15758*
InterPro	IPR001991	http://www.ebi.ac.uk/interpro/entry/IPR001991
InterPro	IPR018107	http://www.ebi.ac.uk/interpro/entry/IPR018107
Jabion	6510	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6510
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6510	http://www.genome.jp/dbget-bin/www_bget?hsa:6510
KEGG_Orthology	KO:K05616	http://www.genome.jp/dbget-bin/www_bget?KO:K05616
KEGG_Pathway	ko04974	http://www.genome.jp/kegg-bin/show_pathway?ko04974
MIM	109190	http://www.ncbi.nlm.nih.gov/omim/109190
MINT	MINT-5001314	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5001314
OMA	GTDQDGM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GTDQDGM
OrthoDB	EOG091G0UCE	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0UCE
PANTHER	PTHR11958	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11958
PRINTS	PR00173	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00173
PROSITE	PS00713	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00713
PROSITE	PS00714	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00714
PSORT	swissprot:AAAT_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AAAT_HUMAN
PSORT-B	swissprot:AAAT_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AAAT_HUMAN
PSORT2	swissprot:AAAT_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AAAT_HUMAN
Pfam	PF00375	http://pfam.xfam.org/family/PF00375
PharmGKB	PA35830	http://www.pharmgkb.org/do/serve?objId=PA35830&objCls=Gene
Phobius	swissprot:AAAT_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AAAT_HUMAN
PhylomeDB	Q15758	http://phylomedb.org/?seqid=Q15758
ProteinModelPortal	Q15758	http://www.proteinmodelportal.org/query/uniprot/Q15758
PubMed	10051606	http://www.ncbi.nlm.nih.gov/pubmed/10051606
PubMed	10196349	http://www.ncbi.nlm.nih.gov/pubmed/10196349
PubMed	10708449	http://www.ncbi.nlm.nih.gov/pubmed/10708449
PubMed	11350958	http://www.ncbi.nlm.nih.gov/pubmed/11350958
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17081065	http://www.ncbi.nlm.nih.gov/pubmed/17081065
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19349973	http://www.ncbi.nlm.nih.gov/pubmed/19349973
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	23492904	http://www.ncbi.nlm.nih.gov/pubmed/23492904
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	8702519	http://www.ncbi.nlm.nih.gov/pubmed/8702519
Reactome	R-HSA-352230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-352230
RefSeq	NP_001138616	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001138616
RefSeq	NP_001138617	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001138617
RefSeq	NP_005619	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005619
STRING	9606.ENSP00000444408	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000444408&targetmode=cogs
SUPFAM	SSF118215	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF118215
TCDB	2.A.23.3	http://www.tcdb.org/search/result.php?tc=2.A.23.3
UCSC	uc002pfr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002pfr&org=rat
UniGene	Hs.631582	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.631582
UniProtKB	AAAT_HUMAN	http://www.uniprot.org/uniprot/AAAT_HUMAN
UniProtKB-AC	Q15758	http://www.uniprot.org/uniprot/Q15758
charge	swissprot:AAAT_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AAAT_HUMAN
eggNOG	COG1301	http://eggnogapi.embl.de/nog_data/html/tree/COG1301
eggNOG	KOG3787	http://eggnogapi.embl.de/nog_data/html/tree/KOG3787
epestfind	swissprot:AAAT_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AAAT_HUMAN
garnier	swissprot:AAAT_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AAAT_HUMAN
helixturnhelix	swissprot:AAAT_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AAAT_HUMAN
hmoment	swissprot:AAAT_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AAAT_HUMAN
iep	swissprot:AAAT_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AAAT_HUMAN
inforesidue	swissprot:AAAT_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AAAT_HUMAN
neXtProt	NX_Q15758	http://www.nextprot.org/db/entry/NX_Q15758
octanol	swissprot:AAAT_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AAAT_HUMAN
pepcoil	swissprot:AAAT_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AAAT_HUMAN
pepdigest	swissprot:AAAT_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AAAT_HUMAN
pepinfo	swissprot:AAAT_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AAAT_HUMAN
pepnet	swissprot:AAAT_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AAAT_HUMAN
pepstats	swissprot:AAAT_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AAAT_HUMAN
pepwheel	swissprot:AAAT_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AAAT_HUMAN
pepwindow	swissprot:AAAT_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AAAT_HUMAN
sigcleave	swissprot:AAAT_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AAAT_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNB2_HUMAN	Voltage-gated potassium channel subunit Kv2.2
# BIOPHYSICOCHEMICAL PROPERTIES	KCNB2_HUMAN	Kinetic parameters  Note=Homotetrameric channels expressed in xenopus oocytes or in mammalian non-neuronal cells display delayed-rectifier voltage- dependent potassium currents which are activated during membrane depolarization, i.e within a risetime of about 20 msec. After that, inactivate very slowly. Their activation requires low threshold potentials of about -20 to -30 mV, with a midpoint activation at about 10 mV. For inactivation, the voltage at half-maximal amplitude is about -30 mV. Channels have an unitary conductance of about 14 pS. The voltage-dependence of activation and inactivation and other channel characteristics vary depending on the experimental conditions, the expression system and post-translational modifications. {ECO 0000250|UniProtKB Q63099, ECO 0000305|PubMed 10414301}; 
# BioGrid	114724	6
# DOMAIN	KCNB2_HUMAN	The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. {ECO 0000250|UniProtKB P63142}. 
# DrugBank	DB06637	Dalfampridine
# ENZYME REGULATION	KCNB2_HUMAN	Inhibited by quinine at micromolar levels. Modestly sensitive to millimolar levels of tetraethylammonium (TEA) and 4-aminopyridine (4-AP). {ECO 0000250|UniProtKB Q63099, ECO 0000250|UniProtKB Q95167, ECO 0000305|PubMed 10414301}. 
# Ensembl	ENST00000523207	ENSP00000430846; ENSG00000182674
# FUNCTION	KCNB2_HUMAN	Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non- conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. {ECO 0000250|UniProtKB A6H8H5, ECO 0000250|UniProtKB Q63099}. 
# GO_component	GO:0005622	intracellular; IEA:GOC.
# GO_component	GO:0005886	plasma membrane; ISS:UniProtKB.
# GO_component	GO:0008076	voltage-gated potassium channel complex; ISS:UniProtKB.
# GO_component	GO:0030425	dendrite; ISS:UniProtKB.
# GO_component	GO:0032809	neuronal cell body membrane; ISS:UniProtKB.
# GO_component	GO:0043204	perikaryon; IEA:UniProtKB-SubCell.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; ISS:UniProtKB.
# GO_function	GO:0046982	protein heterodimerization activity; ISS:UniProtKB.
# GO_process	GO:0006813	potassium ion transport; ISS:UniProtKB.
# GO_process	GO:0006940	regulation of smooth muscle contraction; TAS:ProtInc.
# GO_process	GO:0051260	protein homooligomerization; IEA:InterPro.
# GO_process	GO:0071805	potassium ion transmembrane transport; ISS:UniProtKB.
# GO_process	GO:0072661	protein targeting to plasma membrane; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005622	intracellular
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006605	protein targeting
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0055085	transmembrane transport
# GOslim_process	GO:0061024	membrane organization
# Genevisible	Q92953	HS
# HGNC	HGNC:6232	KCNB2
# InterPro	IPR000210	BTB/POZ_dom
# InterPro	IPR003131	T1-type_BTB
# InterPro	IPR003968	K_chnl_volt-dep_Kv
# InterPro	IPR003973	K_chnl_volt-dep_Kv2
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR005826	K_chnl_volt-dep_Kv2.2
# InterPro	IPR011333	SKP1/BTB/POZ
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko04040	Ion channels
# MIM	607738	gene
# Organism	KCNB2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11537	PTHR11537
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01491	KVCHANNEL
# PRINTS	PR01495	SHABCHANNEL
# PRINTS	PR01515	KV22CHANNEL
# PTM	KCNB2_HUMAN	Phosphorylated. {ECO 0000250|UniProtKB Q63099}. 
# Pfam	PF00520	Ion_trans
# Pfam	PF02214	BTB_2
# Pfam	PF03521	Kv2channel
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# RecName	Potassium voltage-gated channel subfamily B member 2 {ECO:0000312|HGNC	HGNC:6232}
# RefSeq	NP_004761	NM_004770.2
# SEQUENCE CAUTION	Sequence=AAB08433.1; Type=Frameshift; Positions=768; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily. {ECO	0000305}. 
# SMART	SM00225	BTB
# SUBCELLULAR LOCATION	KCNB2_HUMAN	Cell membrane {ECO 0000250|UniProtKB Q63099}; Multi-pass membrane protein {ECO 0000250|UniProtKB Q63099}. Perikaryon {ECO 0000250|UniProtKB Q63099}. Cell projection, dendrite {ECO 0000250|UniProtKB Q63099}. Note=Localized uniformly throughout cell bodies and dendrites. Colocalizes with KCNB1 to high-density somatodendritic clusters on cortical pyramidal neurons. {ECO 0000250|UniProtKB Q63099}. 
# SUBUNIT	Homotetramer or heterotetramer with KCNB1. Heterotetramer with KCNS1 and KCNS2. {ECO:0000250|UniProtKB	Q63099}. 
# SUPFAM	SSF54695	SSF54695
# UCSC	uc003xzb	human
# eggNOG	COG1226	LUCA
# eggNOG	KOG3713	Eukaryota
BLAST	swissprot:KCNB2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNB2_HUMAN
BioCyc	ZFISH:G66-31681-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31681-MONOMER
COXPRESdb	9312	http://coxpresdb.jp/data/gene/9312.shtml
CleanEx	HS_KCNB2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNB2
DOI	10.1111/j.1749-6632.1999.tb11293.x	http://dx.doi.org/10.1111/j.1749-6632.1999.tb11293.x
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DrugBank	DB06637	http://www.drugbank.ca/drugs/DB06637
EMBL	AF338730	http://www.ebi.ac.uk/ena/data/view/AF338730
EMBL	AF450111	http://www.ebi.ac.uk/ena/data/view/AF450111
EMBL	U69962	http://www.ebi.ac.uk/ena/data/view/U69962
Ensembl	ENST00000523207	http://www.ensembl.org/id/ENST00000523207
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0032809	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032809
GO_component	GO:0043204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043204
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_function	GO:0046982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046982
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0006940	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006940
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GO_process	GO:0072661	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072661
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
GeneCards	KCNB2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNB2
GeneID	9312	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9312
GeneTree	ENSGT00760000118981	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118981
HGNC	HGNC:6232	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6232
HOGENOM	HOG000113206	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000113206&db=HOGENOM6
HOVERGEN	HBG052225	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052225&db=HOVERGEN
InParanoid	Q92953	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q92953
IntAct	Q92953	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q92953*
InterPro	IPR000210	http://www.ebi.ac.uk/interpro/entry/IPR000210
InterPro	IPR003131	http://www.ebi.ac.uk/interpro/entry/IPR003131
InterPro	IPR003968	http://www.ebi.ac.uk/interpro/entry/IPR003968
InterPro	IPR003973	http://www.ebi.ac.uk/interpro/entry/IPR003973
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR005826	http://www.ebi.ac.uk/interpro/entry/IPR005826
InterPro	IPR011333	http://www.ebi.ac.uk/interpro/entry/IPR011333
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	9312	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9312
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:9312	http://www.genome.jp/dbget-bin/www_bget?hsa:9312
KEGG_Orthology	KO:K04886	http://www.genome.jp/dbget-bin/www_bget?KO:K04886
MIM	607738	http://www.ncbi.nlm.nih.gov/omim/607738
OMA	IHSNPGD	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IHSNPGD
OrthoDB	EOG091G0FP3	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0FP3
PANTHER	PTHR11537	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01491	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01491
PRINTS	PR01495	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01495
PRINTS	PR01515	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01515
PSORT	swissprot:KCNB2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNB2_HUMAN
PSORT-B	swissprot:KCNB2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNB2_HUMAN
PSORT2	swissprot:KCNB2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNB2_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF02214	http://pfam.xfam.org/family/PF02214
Pfam	PF03521	http://pfam.xfam.org/family/PF03521
PharmGKB	PA30025	http://www.pharmgkb.org/do/serve?objId=PA30025&objCls=Gene
Phobius	swissprot:KCNB2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNB2_HUMAN
PhylomeDB	Q92953	http://phylomedb.org/?seqid=Q92953
ProteinModelPortal	Q92953	http://www.proteinmodelportal.org/query/uniprot/Q92953
PubMed	10414301	http://www.ncbi.nlm.nih.gov/pubmed/10414301
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	9612272	http://www.ncbi.nlm.nih.gov/pubmed/9612272
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
RefSeq	NP_004761	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004761
SMART	SM00225	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225
SMR	Q92953	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q92953
STRING	9606.ENSP00000430846	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000430846&targetmode=cogs
SUPFAM	SSF54695	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54695
UCSC	uc003xzb	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003xzb&org=rat
UniGene	Hs.661102	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.661102
UniProtKB	KCNB2_HUMAN	http://www.uniprot.org/uniprot/KCNB2_HUMAN
UniProtKB-AC	Q92953	http://www.uniprot.org/uniprot/Q92953
charge	swissprot:KCNB2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNB2_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG3713	http://eggnogapi.embl.de/nog_data/html/tree/KOG3713
epestfind	swissprot:KCNB2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNB2_HUMAN
garnier	swissprot:KCNB2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNB2_HUMAN
helixturnhelix	swissprot:KCNB2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNB2_HUMAN
hmoment	swissprot:KCNB2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNB2_HUMAN
iep	swissprot:KCNB2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNB2_HUMAN
inforesidue	swissprot:KCNB2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNB2_HUMAN
neXtProt	NX_Q92953	http://www.nextprot.org/db/entry/NX_Q92953
octanol	swissprot:KCNB2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNB2_HUMAN
pepcoil	swissprot:KCNB2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNB2_HUMAN
pepdigest	swissprot:KCNB2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNB2_HUMAN
pepinfo	swissprot:KCNB2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNB2_HUMAN
pepnet	swissprot:KCNB2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNB2_HUMAN
pepstats	swissprot:KCNB2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNB2_HUMAN
pepwheel	swissprot:KCNB2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNB2_HUMAN
pepwindow	swissprot:KCNB2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNB2_HUMAN
sigcleave	swissprot:KCNB2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNB2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S6A13_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9NSD5-1; Sequence=Displayed; Name=2; IsoId=Q9NSD5-2; Sequence=VSP_043070; Note=No experimental confirmation available.; Name=3; IsoId=Q9NSD5-3; Sequence=VSP_044887, VSP_044888; 
# AltName	S6A13_HUMAN	Solute carrier family 6 member 13
# BIOPHYSICOCHEMICAL PROPERTIES	S6A13_HUMAN	Kinetic parameters  KM=3.7 uM for GABA {ECO 0000269|PubMed 17502375}; KM=20.2 uM for beta-alanine {ECO 0000269|PubMed 17502375}; 
# CCDS	CCDS53729	-. [Q9NSD5-2]
# CCDS	CCDS58198	-. [Q9NSD5-3]
# CCDS	CCDS8502	-. [Q9NSD5-1]
# Ensembl	ENST00000343164	ENSP00000339260; ENSG00000010379. [Q9NSD5-1]
# Ensembl	ENST00000436453	ENSP00000389316; ENSG00000010379. [Q9NSD5-3]
# Ensembl	ENST00000445055	ENSP00000407104; ENSG00000010379. [Q9NSD5-2]
# ExpressionAtlas	Q9NSD5	baseline and differential
# FUNCTION	S6A13_HUMAN	Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be involved in beta-alanine transport. {ECO 0000269|PubMed 17502375, ECO 0000269|PubMed 22932902}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0043005	neuron projection; IBA:GO_Central.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	S6A13_HUMAN	GO 0005328 neurotransmitter sodium symporter activity; IEA InterPro.
# GO_function	S6A13_HUMAN	GO 0005332 gamma-aminobutyric acid sodium symporter activity; IBA GO_Central.
# GO_process	GO:0006836	neurotransmitter transport; IBA:GO_Central.
# GO_process	GO:0007268	chemical synaptic transmission; IBA:GO_Central.
# GO_process	GO:0015812	gamma-aminobutyric acid transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# Genevisible	Q9NSD5	HS
# HGNC	HGNC:11046	SLC6A13
# InterPro	IPR000175	Na/ntran_symport
# InterPro	IPR002981	Na/ntran_symport_GABA_GAT2
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Brite	ko04040	 Ion channels
# MIM	615097	gene
# Organism	S6A13_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11616	PTHR11616
# PRINTS	PR00176	NANEUSMPORT
# PRINTS	PR01196	GAT2TRNSPORT
# PROSITE	PS00610	NA_NEUROTRAN_SYMP_1
# PROSITE	PS00754	NA_NEUROTRAN_SYMP_2
# PROSITE	PS50267	NA_NEUROTRAN_SYMP_3
# Pfam	PF00209	SNF
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-442660	Na+/Cl- dependent neurotransmitter transporters
# Reactome	R-HSA-888593	Reuptake of GABA
# RecName	S6A13_HUMAN	Sodium- and chloride-dependent GABA transporter 2
# RefSeq	NP_001177926	NM_001190997.2. [Q9NSD5-2]
# RefSeq	NP_001230321	NM_001243392.1. [Q9NSD5-3]
# RefSeq	NP_057699	NM_016615.4. [Q9NSD5-1]
# SEQUENCE CAUTION	Sequence=AAF64247.1; Type=Frameshift; Positions=542; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S6A13_HUMAN	Cell membrane {ECO 0000269|PubMed 22932902}; Multi-pass membrane protein {ECO 0000269|PubMed 22932902}. 
# TCDB	2.A.22.3.10:the neurotransmitter	sodium symporter (nss) family
# TISSUE SPECIFICITY	S6A13_HUMAN	Expressed in brain, kidney, lung, liver and testis. {ECO 0000269|PubMed 11824941, ECO 0000269|PubMed 17502375}. 
# UCSC	uc001qic	human. [Q9NSD5-1]
# eggNOG	COG0733	LUCA
# eggNOG	KOG3659	Eukaryota
BLAST	swissprot:S6A13_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S6A13_HUMAN
BioCyc	ZFISH:ENSG00000010379-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000010379-MONOMER
COXPRESdb	6540	http://coxpresdb.jp/data/gene/6540.shtml
CleanEx	HS_SLC6A13	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC6A13
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M112.388157	http://dx.doi.org/10.1074/jbc.M112.388157
DOI	10.1074/jbc.M702111200	http://dx.doi.org/10.1074/jbc.M702111200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1139/y01-082	http://dx.doi.org/10.1139/y01-082
EMBL	AC007406	http://www.ebi.ac.uk/ena/data/view/AC007406
EMBL	AF462445	http://www.ebi.ac.uk/ena/data/view/AF462445
EMBL	AK296127	http://www.ebi.ac.uk/ena/data/view/AK296127
EMBL	AK313511	http://www.ebi.ac.uk/ena/data/view/AK313511
EMBL	BC020867	http://www.ebi.ac.uk/ena/data/view/BC020867
EMBL	BC022392	http://www.ebi.ac.uk/ena/data/view/BC022392
EMBL	CH471116	http://www.ebi.ac.uk/ena/data/view/CH471116
EMBL	U76343	http://www.ebi.ac.uk/ena/data/view/U76343
Ensembl	ENST00000343164	http://www.ensembl.org/id/ENST00000343164
Ensembl	ENST00000436453	http://www.ensembl.org/id/ENST00000436453
Ensembl	ENST00000445055	http://www.ensembl.org/id/ENST00000445055
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0043005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043005
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005328
GO_function	GO:0005332	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005332
GO_process	GO:0006836	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006836
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0015812	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015812
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GeneCards	SLC6A13	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC6A13
GeneID	6540	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6540
GeneTree	ENSGT00760000118857	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118857
HGNC	HGNC:11046	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11046
HOGENOM	HOG000150680	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000150680&db=HOGENOM6
HOVERGEN	HBG071421	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG071421&db=HOVERGEN
HPA	HPA052726	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA052726
InParanoid	Q9NSD5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NSD5
IntAct	Q9NSD5	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NSD5*
InterPro	IPR000175	http://www.ebi.ac.uk/interpro/entry/IPR000175
InterPro	IPR002981	http://www.ebi.ac.uk/interpro/entry/IPR002981
Jabion	6540	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6540
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:6540	http://www.genome.jp/dbget-bin/www_bget?hsa:6540
KEGG_Orthology	KO:K05039	http://www.genome.jp/dbget-bin/www_bget?KO:K05039
MIM	615097	http://www.ncbi.nlm.nih.gov/omim/615097
OMA	GGCHHEW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GGCHHEW
OrthoDB	EOG091G08PX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08PX
PANTHER	PTHR11616	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11616
PRINTS	PR00176	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00176
PRINTS	PR01196	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01196
PROSITE	PS00610	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00610
PROSITE	PS00754	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00754
PROSITE	PS50267	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50267
PSORT	swissprot:S6A13_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S6A13_HUMAN
PSORT-B	swissprot:S6A13_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S6A13_HUMAN
PSORT2	swissprot:S6A13_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S6A13_HUMAN
Pfam	PF00209	http://pfam.xfam.org/family/PF00209
PharmGKB	PA35909	http://www.pharmgkb.org/do/serve?objId=PA35909&objCls=Gene
Phobius	swissprot:S6A13_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S6A13_HUMAN
PhylomeDB	Q9NSD5	http://phylomedb.org/?seqid=Q9NSD5
ProteinModelPortal	Q9NSD5	http://www.proteinmodelportal.org/query/uniprot/Q9NSD5
PubMed	11824941	http://www.ncbi.nlm.nih.gov/pubmed/11824941
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	17502375	http://www.ncbi.nlm.nih.gov/pubmed/17502375
PubMed	22932902	http://www.ncbi.nlm.nih.gov/pubmed/22932902
Reactome	R-HSA-442660	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442660
Reactome	R-HSA-888593	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-888593
RefSeq	NP_001177926	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001177926
RefSeq	NP_001230321	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001230321
RefSeq	NP_057699	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_057699
SMR	Q9NSD5	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9NSD5
STRING	9606.ENSP00000339260	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000339260&targetmode=cogs
TCDB	2.A.22.3.10	http://www.tcdb.org/search/result.php?tc=2.A.22.3.10
UCSC	uc001qic	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001qic&org=rat
UniGene	Hs.504398	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.504398
UniGene	Hs.733878	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.733878
UniProtKB	S6A13_HUMAN	http://www.uniprot.org/uniprot/S6A13_HUMAN
UniProtKB-AC	Q9NSD5	http://www.uniprot.org/uniprot/Q9NSD5
charge	swissprot:S6A13_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S6A13_HUMAN
eggNOG	COG0733	http://eggnogapi.embl.de/nog_data/html/tree/COG0733
eggNOG	KOG3659	http://eggnogapi.embl.de/nog_data/html/tree/KOG3659
epestfind	swissprot:S6A13_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S6A13_HUMAN
garnier	swissprot:S6A13_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S6A13_HUMAN
helixturnhelix	swissprot:S6A13_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S6A13_HUMAN
hmoment	swissprot:S6A13_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S6A13_HUMAN
iep	swissprot:S6A13_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S6A13_HUMAN
inforesidue	swissprot:S6A13_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S6A13_HUMAN
neXtProt	NX_Q9NSD5	http://www.nextprot.org/db/entry/NX_Q9NSD5
octanol	swissprot:S6A13_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S6A13_HUMAN
pepcoil	swissprot:S6A13_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S6A13_HUMAN
pepdigest	swissprot:S6A13_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S6A13_HUMAN
pepinfo	swissprot:S6A13_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S6A13_HUMAN
pepnet	swissprot:S6A13_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S6A13_HUMAN
pepstats	swissprot:S6A13_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S6A13_HUMAN
pepwheel	swissprot:S6A13_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S6A13_HUMAN
pepwindow	swissprot:S6A13_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S6A13_HUMAN
sigcleave	swissprot:S6A13_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S6A13_HUMAN
## Database	ID	URL or Descriptions
# AltName	TI17A_HUMAN	Inner membrane preprotein translocase Tim17a
# BioGrid	115707	8
# ChiTaRS	TIMM17A	human
# Ensembl	ENST00000367287	ENSP00000356256; ENSG00000134375
# FUNCTION	TI17A_HUMAN	Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. 
# GO_component	GO:0005654	nucleoplasm; IDA:HPA.
# GO_component	GO:0005739	mitochondrion; IDA:HPA.
# GO_component	GO:0005743	mitochondrial inner membrane; IDA:GO_Central.
# GO_component	GO:0005744	mitochondrial inner membrane presequence translocase complex; IDA:BHF-UCL.
# GO_component	GO:0031305	integral component of mitochondrial inner membrane; IDA:BHF-UCL.
# GO_function	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity; IEA:InterPro.
# GO_process	GO:0006626	protein targeting to mitochondrion; TAS:ProtInc.
# GO_process	GO:0030150	protein import into mitochondrial matrix; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006605	protein targeting
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q99595	HS
# HGNC	HGNC:17315	TIMM17A
# IntAct	Q99595	3
# InterPro	IPR003397	Tim17/Tim22/Tim23/PMP24
# InterPro	IPR005678	Tim17
# MIM	605057	gene
# Organism	TI17A_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10485	PTHR10485
# Pfam	PF02466	Tim17
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-1268020	Mitochondrial protein import
# RecName	TI17A_HUMAN	Mitochondrial import inner membrane translocase subunit Tim17-A
# RefSeq	NP_006326	NM_006335.2
# SIMILARITY	Belongs to the Tim17/Tim22/Tim23 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	TI17A_HUMAN	Mitochondrion inner membrane; Multi-pass membrane protein. 
# SUBUNIT	Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50. The complex interacts with the TIMM44 component of the PAM complex and with DNAJC15. {ECO:0000269|PubMed	23263864}. 
# TIGRFAMs	TIGR00980	3a0801so1tim17
# UCSC	uc001gxc	human
# eggNOG	COG5596	LUCA
# eggNOG	KOG1652	Eukaryota
BLAST	swissprot:TI17A_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TI17A_HUMAN
BioCyc	ZFISH:ENSG00000134375-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000134375-MONOMER
COXPRESdb	10440	http://coxpresdb.jp/data/gene/10440.shtml
CleanEx	HS_TIMM17A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TIMM17A
DOI	10.1006/jmbi.1996.0522	http://dx.doi.org/10.1006/jmbi.1996.0522
DOI	10.1006/jmbi.1999.2751	http://dx.doi.org/10.1006/jmbi.1999.2751
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/hmg/dds541	http://dx.doi.org/10.1093/hmg/dds541
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF106622	http://www.ebi.ac.uk/ena/data/view/AF106622
EMBL	AK315602	http://www.ebi.ac.uk/ena/data/view/AK315602
EMBL	BC000294	http://www.ebi.ac.uk/ena/data/view/BC000294
EMBL	BC004439	http://www.ebi.ac.uk/ena/data/view/BC004439
EMBL	BC007106	http://www.ebi.ac.uk/ena/data/view/BC007106
EMBL	BC009784	http://www.ebi.ac.uk/ena/data/view/BC009784
EMBL	BC015098	http://www.ebi.ac.uk/ena/data/view/BC015098
EMBL	BC020833	http://www.ebi.ac.uk/ena/data/view/BC020833
EMBL	CH471067	http://www.ebi.ac.uk/ena/data/view/CH471067
EMBL	X97544	http://www.ebi.ac.uk/ena/data/view/X97544
Ensembl	ENST00000367287	http://www.ensembl.org/id/ENST00000367287
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005744	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005744
GO_component	GO:0031305	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031305
GO_function	GO:0015450	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015450
GO_process	GO:0006626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006626
GO_process	GO:0030150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030150
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	TIMM17A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TIMM17A
GeneID	10440	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10440
GeneTree	ENSGT00390000017780	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000017780
HGNC	HGNC:17315	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17315
HOGENOM	HOG000183190	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000183190&db=HOGENOM6
HOVERGEN	HBG054233	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054233&db=HOVERGEN
HPA	HPA010083	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA010083
InParanoid	Q99595	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q99595
IntAct	Q99595	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q99595*
InterPro	IPR003397	http://www.ebi.ac.uk/interpro/entry/IPR003397
InterPro	IPR005678	http://www.ebi.ac.uk/interpro/entry/IPR005678
Jabion	10440	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10440
KEGG_Gene	hsa:10440	http://www.genome.jp/dbget-bin/www_bget?hsa:10440
MIM	605057	http://www.ncbi.nlm.nih.gov/omim/605057
MINT	MINT-1411052	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1411052
OMA	VGICFTR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VGICFTR
OrthoDB	EOG091G0PGZ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0PGZ
PANTHER	PTHR10485	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10485
PSORT	swissprot:TI17A_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TI17A_HUMAN
PSORT-B	swissprot:TI17A_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TI17A_HUMAN
PSORT2	swissprot:TI17A_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TI17A_HUMAN
Pfam	PF02466	http://pfam.xfam.org/family/PF02466
PharmGKB	PA38228	http://www.pharmgkb.org/do/serve?objId=PA38228&objCls=Gene
Phobius	swissprot:TI17A_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TI17A_HUMAN
PhylomeDB	Q99595	http://phylomedb.org/?seqid=Q99595
ProteinModelPortal	Q99595	http://www.proteinmodelportal.org/query/uniprot/Q99595
PubMed	10339406	http://www.ncbi.nlm.nih.gov/pubmed/10339406
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23263864	http://www.ncbi.nlm.nih.gov/pubmed/23263864
PubMed	8893850	http://www.ncbi.nlm.nih.gov/pubmed/8893850
Reactome	R-HSA-1268020	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1268020
RefSeq	NP_006326	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006326
STRING	9606.ENSP00000356256	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000356256&targetmode=cogs
TIGRFAMs	TIGR00980	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00980
UCSC	uc001gxc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001gxc&org=rat
UniGene	Hs.20716	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.20716
UniProtKB	TI17A_HUMAN	http://www.uniprot.org/uniprot/TI17A_HUMAN
UniProtKB-AC	Q99595	http://www.uniprot.org/uniprot/Q99595
charge	swissprot:TI17A_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TI17A_HUMAN
eggNOG	COG5596	http://eggnogapi.embl.de/nog_data/html/tree/COG5596
eggNOG	KOG1652	http://eggnogapi.embl.de/nog_data/html/tree/KOG1652
epestfind	swissprot:TI17A_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TI17A_HUMAN
garnier	swissprot:TI17A_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TI17A_HUMAN
helixturnhelix	swissprot:TI17A_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TI17A_HUMAN
hmoment	swissprot:TI17A_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TI17A_HUMAN
iep	swissprot:TI17A_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TI17A_HUMAN
inforesidue	swissprot:TI17A_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TI17A_HUMAN
neXtProt	NX_Q99595	http://www.nextprot.org/db/entry/NX_Q99595
octanol	swissprot:TI17A_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TI17A_HUMAN
pepcoil	swissprot:TI17A_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TI17A_HUMAN
pepdigest	swissprot:TI17A_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TI17A_HUMAN
pepinfo	swissprot:TI17A_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TI17A_HUMAN
pepnet	swissprot:TI17A_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TI17A_HUMAN
pepstats	swissprot:TI17A_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TI17A_HUMAN
pepwheel	swissprot:TI17A_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TI17A_HUMAN
pepwindow	swissprot:TI17A_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TI17A_HUMAN
sigcleave	swissprot:TI17A_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TI17A_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S39A2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NP94-1; Sequence=Displayed; Name=2; IsoId=Q9NP94-2; Sequence=VSP_046889, VSP_046890; Note=Gene prediction based on EST data.; 
# AltName	S39A2_HUMAN	6A1
# AltName	S39A2_HUMAN	Eti-1
# AltName	S39A2_HUMAN	Solute carrier family 39 member 2
# AltName	S39A2_HUMAN	Zrt- and Irt-like protein 2
# CCDS	CCDS58303	-. [Q9NP94-2]
# CCDS	CCDS9563	-. [Q9NP94-1]
# Ensembl	ENST00000298681	ENSP00000298681; ENSG00000165794. [Q9NP94-1]
# Ensembl	ENST00000554422	ENSP00000452568; ENSG00000165794. [Q9NP94-2]
# FUNCTION	S39A2_HUMAN	Mediates zinc uptake. Zinc uptake may be mediated by a Zn(2+)-HCO(3)(-) symport mechanism and can function in the presence of albumin. May also transport other divalent cations. May be important in contact inhibition of normal epithelial cells and loss of its expression may play a role in tumorigenesis. 
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016023	cytoplasmic, membrane-bounded vesicle; IDA:UniProtKB.
# GO_function	GO:0005385	zinc ion transmembrane transporter activity; IMP:UniProtKB.
# GO_process	GO:0006829	zinc II ion transport; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q9NP94	HS
# HGNC	HGNC:17127	SLC39A2
# INDUCTION	S39A2_HUMAN	Shows a dramatic induction in normal epithelial cells contact inhibition. 
# InterPro	IPR003689	ZIP
# KEGG_Brite	ko02001	Solute carrier family
# MIM	612166	gene
# MISCELLANEOUS	S39A2_HUMAN	Zinc uptake is inhibited at pH levels below 7.0 and is stimulated at higher pH and is significantly inhibited by Cu(2+), Co(2+) and Mn(2+) ions. Not inhibited by Fe(2+). 
# Organism	S39A2_HUMAN	Homo sapiens (Human)
# Pfam	PF02535	Zip
# Proteomes	UP000005640	Chromosome 14
# Reactome	R-HSA-442380	Zinc influx into cells by the SLC39 gene family
# RecName	S39A2_HUMAN	Zinc transporter ZIP2
# RefSeq	NP_001243517	NM_001256588.1. [Q9NP94-2]
# RefSeq	NP_055394	NM_014579.3. [Q9NP94-1]
# SIMILARITY	Belongs to the ZIP transporter (TC 2.A.5) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S39A2_HUMAN	Cell membrane; Multi-pass membrane protein. 
# TCDB	2.A.5.3	the zinc (zn(2+))-iron (fe(2+)) permease (zip) family
# TISSUE SPECIFICITY	S39A2_HUMAN	Expressed only in prostate and uterine epithelial cells. 
# UCSC	uc001vyr	human. [Q9NP94-1]
# eggNOG	ENOG4111GP2	LUCA
# eggNOG	KOG1558	Eukaryota
BLAST	swissprot:S39A2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S39A2_HUMAN
BioCyc	ZFISH:ENSG00000165794-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000165794-MONOMER
COXPRESdb	29986	http://coxpresdb.jp/data/gene/29986.shtml
CleanEx	HS_SLC39A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC39A2
DOI	10.1038/nature01348	http://dx.doi.org/10.1038/nature01348
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.275.8.5560	http://dx.doi.org/10.1074/jbc.275.8.5560
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF186081	http://www.ebi.ac.uk/ena/data/view/AF186081
EMBL	AK314974	http://www.ebi.ac.uk/ena/data/view/AK314974
EMBL	AL161668	http://www.ebi.ac.uk/ena/data/view/AL161668
EMBL	AL355922	http://www.ebi.ac.uk/ena/data/view/AL355922
EMBL	AY029483	http://www.ebi.ac.uk/ena/data/view/AY029483
EMBL	BC096723	http://www.ebi.ac.uk/ena/data/view/BC096723
EMBL	BC098254	http://www.ebi.ac.uk/ena/data/view/BC098254
EMBL	BC110057	http://www.ebi.ac.uk/ena/data/view/BC110057
EMBL	D83039	http://www.ebi.ac.uk/ena/data/view/D83039
Ensembl	ENST00000298681	http://www.ensembl.org/id/ENST00000298681
Ensembl	ENST00000554422	http://www.ensembl.org/id/ENST00000554422
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016023	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016023
GO_function	GO:0005385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005385
GO_process	GO:0006829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006829
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC39A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC39A2
GeneID	29986	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29986
GeneTree	ENSGT00530000063242	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063242
H-InvDB	HIX0202098	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0202098
HGNC	HGNC:17127	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17127
HOGENOM	HOG000236331	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236331&db=HOGENOM6
HOVERGEN	HBG015174	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG015174&db=HOVERGEN
HPA	HPA030489	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA030489
InParanoid	Q9NP94	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NP94
InterPro	IPR003689	http://www.ebi.ac.uk/interpro/entry/IPR003689
Jabion	29986	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=29986
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:29986	http://www.genome.jp/dbget-bin/www_bget?hsa:29986
KEGG_Orthology	KO:K14709	http://www.genome.jp/dbget-bin/www_bget?KO:K14709
MIM	612166	http://www.ncbi.nlm.nih.gov/omim/612166
OMA	QDEEWGG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QDEEWGG
OrthoDB	EOG091G0DW2	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0DW2
PSORT	swissprot:S39A2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S39A2_HUMAN
PSORT-B	swissprot:S39A2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S39A2_HUMAN
PSORT2	swissprot:S39A2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S39A2_HUMAN
Pfam	PF02535	http://pfam.xfam.org/family/PF02535
PharmGKB	PA38202	http://www.pharmgkb.org/do/serve?objId=PA38202&objCls=Gene
Phobius	swissprot:S39A2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S39A2_HUMAN
PhylomeDB	Q9NP94	http://phylomedb.org/?seqid=Q9NP94
ProteinModelPortal	Q9NP94	http://www.proteinmodelportal.org/query/uniprot/Q9NP94
PubMed	10681536	http://www.ncbi.nlm.nih.gov/pubmed/10681536
PubMed	12508121	http://www.ncbi.nlm.nih.gov/pubmed/12508121
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	7751801	http://www.ncbi.nlm.nih.gov/pubmed/7751801
Reactome	R-HSA-442380	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442380
RefSeq	NP_001243517	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243517
RefSeq	NP_055394	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055394
STRING	9606.ENSP00000298681	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000298681&targetmode=cogs
TCDB	2.A.5.3	http://www.tcdb.org/search/result.php?tc=2.A.5.3
UCSC	uc001vyr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001vyr&org=rat
UniGene	Hs.175783	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.175783
UniProtKB	S39A2_HUMAN	http://www.uniprot.org/uniprot/S39A2_HUMAN
UniProtKB-AC	Q9NP94	http://www.uniprot.org/uniprot/Q9NP94
charge	swissprot:S39A2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S39A2_HUMAN
eggNOG	ENOG4111GP2	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111GP2
eggNOG	KOG1558	http://eggnogapi.embl.de/nog_data/html/tree/KOG1558
epestfind	swissprot:S39A2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S39A2_HUMAN
garnier	swissprot:S39A2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S39A2_HUMAN
helixturnhelix	swissprot:S39A2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S39A2_HUMAN
hmoment	swissprot:S39A2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S39A2_HUMAN
iep	swissprot:S39A2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S39A2_HUMAN
inforesidue	swissprot:S39A2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S39A2_HUMAN
neXtProt	NX_Q9NP94	http://www.nextprot.org/db/entry/NX_Q9NP94
octanol	swissprot:S39A2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S39A2_HUMAN
pepcoil	swissprot:S39A2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S39A2_HUMAN
pepdigest	swissprot:S39A2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S39A2_HUMAN
pepinfo	swissprot:S39A2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S39A2_HUMAN
pepnet	swissprot:S39A2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S39A2_HUMAN
pepstats	swissprot:S39A2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S39A2_HUMAN
pepwheel	swissprot:S39A2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S39A2_HUMAN
pepwindow	swissprot:S39A2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S39A2_HUMAN
sigcleave	swissprot:S39A2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S39A2_HUMAN
## Database	ID	URL or Descriptions
# AltName	S19A3_HUMAN	Solute carrier family 19 member 3
# BioGrid	123266	5
# ChiTaRS	SLC19A3	human
# DISEASE	S19A3_HUMAN	Thiamine metabolism dysfunction syndrome 2, biotin- or thiamine-responsive type (THMD2) [MIM 607483]  An autosomal recessive metabolic disorder characterized by episodic encephalopathy, often triggered by febrile illness, presenting as confusion, seizures, external ophthalmoplegia, dysphagia, and sometimes coma and death. If untreated, encephalopathies can result in permanent dystonia. Brain imaging may show characteristic bilateral lesions of the basal ganglia. {ECO 0000269|PubMed 15871139}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00151	L-Cysteine
# Ensembl	ENST00000258403	ENSP00000258403; ENSG00000135917
# Ensembl	ENST00000425817	ENSP00000397393; ENSG00000135917
# ExpressionAtlas	Q9BZV2	baseline and differential
# FUNCTION	S19A3_HUMAN	Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity. {ECO 0000269|PubMed 11731220}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_function	GO:0015234	thiamine transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015403	thiamine uptake transmembrane transporter activity; ISS:BHF-UCL.
# GO_process	GO:0042723	thiamine-containing compound metabolic process; TAS:Reactome.
# GO_process	GO:0071934	thiamine transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006790	sulfur compound metabolic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9BZV2	HS
# HGNC	HGNC:16266	SLC19A3
# IntAct	Q9BZV2	4
# InterPro	IPR002666	Folate_carrier
# InterPro	IPR020846	MFS_dom
# InterPro	IPR028337	ThTr-2
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H01231	[Inherited metabolic disease] Biotin-responsive basal ganglia disease (BBGD)
# KEGG_Pathway	ko04977	Vitamin digestion and absorption
# MIM	606152	gene
# MIM	607483	phenotype
# Organism	S19A3_HUMAN	Homo sapiens (Human)
# Orphanet	199348	Thiamine-responsive encephalopathy
# Orphanet	255241	Leigh syndrome with leukodystrophy
# Orphanet	263410	Infantile spams - psychomotor retardation - progressive brain atrophy - basal ganglia disease
# Orphanet	65284	Biotin-responsive basal ganglia disease
# PANTHER	PTHR10686	PTHR10686
# PIRSF	PIRSF028739	Folate_carrier
# PIRSF	PIRSF500795	Thiamine_transporter_2
# Pfam	PF01770	Folate_carrier
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-196819	Vitamin B1 (thiamin) metabolism
# RecName	S19A3_HUMAN	Thiamine transporter 2
# RefSeq	NP_079519	NM_025243.3
# RefSeq	XP_011510234	XM_011511932.1
# RefSeq	XP_011510235	XM_011511933.1
# SIMILARITY	Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S19A3_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.48.1	the reduced folate carrier (rfc) family
# TIGRFAMs	TIGR00806	rfc
# TISSUE SPECIFICITY	S19A3_HUMAN	Widely expressed but most abundant in placenta, kidney and liver. {ECO 0000269|PubMed 11136550, ECO 0000269|PubMed 15871139}. 
# UCSC	uc002vpi	human
# eggNOG	ENOG410XT34	LUCA
# eggNOG	KOG3810	Eukaryota
BLAST	swissprot:S19A3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S19A3_HUMAN
BioCyc	ZFISH:ENSG00000135917-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000135917-MONOMER
COXPRESdb	80704	http://coxpresdb.jp/data/gene/80704.shtml
CleanEx	HS_SLC19A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC19A3
DOI	10.1006/mgme.2000.3112	http://dx.doi.org/10.1006/mgme.2000.3112
DOI	10.1007/s00424-003-1068-1	http://dx.doi.org/10.1007/s00424-003-1068-1
DOI	10.1016/S0925-4439(01)00073-4	http://dx.doi.org/10.1016/S0925-4439(01)00073-4
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1086/431216	http://dx.doi.org/10.1086/431216
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00151	http://www.drugbank.ca/drugs/DB00151
EMBL	AC064853	http://www.ebi.ac.uk/ena/data/view/AC064853
EMBL	AF271633	http://www.ebi.ac.uk/ena/data/view/AF271633
EMBL	AF283317	http://www.ebi.ac.uk/ena/data/view/AF283317
EMBL	BC032014	http://www.ebi.ac.uk/ena/data/view/BC032014
Ensembl	ENST00000258403	http://www.ensembl.org/id/ENST00000258403
Ensembl	ENST00000425817	http://www.ensembl.org/id/ENST00000425817
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015234
GO_function	GO:0015403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015403
GO_process	GO:0042723	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042723
GO_process	GO:0071934	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071934
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC19A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC19A3
GeneID	80704	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80704
GeneTree	ENSGT00510000046382	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00510000046382
HGNC	HGNC:16266	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16266
HOGENOM	HOG000001583	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000001583&db=HOGENOM6
HOVERGEN	HBG054198	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054198&db=HOVERGEN
HPA	HPA038898	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA038898
InParanoid	Q9BZV2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9BZV2
IntAct	Q9BZV2	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9BZV2*
InterPro	IPR002666	http://www.ebi.ac.uk/interpro/entry/IPR002666
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
InterPro	IPR028337	http://www.ebi.ac.uk/interpro/entry/IPR028337
Jabion	80704	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=80704
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H01231	http://www.genome.jp/dbget-bin/www_bget?H01231
KEGG_Gene	hsa:80704	http://www.genome.jp/dbget-bin/www_bget?hsa:80704
KEGG_Orthology	KO:K14610	http://www.genome.jp/dbget-bin/www_bget?KO:K14610
KEGG_Pathway	ko04977	http://www.genome.jp/kegg-bin/show_pathway?ko04977
MIM	606152	http://www.ncbi.nlm.nih.gov/omim/606152
MIM	607483	http://www.ncbi.nlm.nih.gov/omim/607483
MINT	MINT-5006585	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5006585
OMA	MYIIYST	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MYIIYST
Orphanet	199348	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=199348
Orphanet	255241	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=255241
Orphanet	263410	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=263410
Orphanet	65284	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=65284
OrthoDB	EOG091G0BSJ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0BSJ
PANTHER	PTHR10686	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10686
PSORT	swissprot:S19A3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S19A3_HUMAN
PSORT-B	swissprot:S19A3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S19A3_HUMAN
PSORT2	swissprot:S19A3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S19A3_HUMAN
Pfam	PF01770	http://pfam.xfam.org/family/PF01770
PharmGKB	PA38397	http://www.pharmgkb.org/do/serve?objId=PA38397&objCls=Gene
Phobius	swissprot:S19A3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S19A3_HUMAN
PhylomeDB	Q9BZV2	http://phylomedb.org/?seqid=Q9BZV2
ProteinModelPortal	Q9BZV2	http://www.proteinmodelportal.org/query/uniprot/Q9BZV2
PubMed	11136550	http://www.ncbi.nlm.nih.gov/pubmed/11136550
PubMed	11731220	http://www.ncbi.nlm.nih.gov/pubmed/11731220
PubMed	14770311	http://www.ncbi.nlm.nih.gov/pubmed/14770311
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	15871139	http://www.ncbi.nlm.nih.gov/pubmed/15871139
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
Reactome	R-HSA-196819	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-196819
RefSeq	NP_079519	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_079519
RefSeq	XP_011510234	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011510234
RefSeq	XP_011510235	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011510235
STRING	9606.ENSP00000258403	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000258403&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.48.1	http://www.tcdb.org/search/result.php?tc=2.A.48.1
TIGRFAMs	TIGR00806	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00806
UCSC	uc002vpi	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002vpi&org=rat
UniGene	Hs.221597	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.221597
UniProtKB	S19A3_HUMAN	http://www.uniprot.org/uniprot/S19A3_HUMAN
UniProtKB-AC	Q9BZV2	http://www.uniprot.org/uniprot/Q9BZV2
charge	swissprot:S19A3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S19A3_HUMAN
eggNOG	ENOG410XT34	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XT34
eggNOG	KOG3810	http://eggnogapi.embl.de/nog_data/html/tree/KOG3810
epestfind	swissprot:S19A3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S19A3_HUMAN
garnier	swissprot:S19A3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S19A3_HUMAN
helixturnhelix	swissprot:S19A3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S19A3_HUMAN
hmoment	swissprot:S19A3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S19A3_HUMAN
iep	swissprot:S19A3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S19A3_HUMAN
inforesidue	swissprot:S19A3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S19A3_HUMAN
neXtProt	NX_Q9BZV2	http://www.nextprot.org/db/entry/NX_Q9BZV2
octanol	swissprot:S19A3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S19A3_HUMAN
pepcoil	swissprot:S19A3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S19A3_HUMAN
pepdigest	swissprot:S19A3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S19A3_HUMAN
pepinfo	swissprot:S19A3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S19A3_HUMAN
pepnet	swissprot:S19A3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S19A3_HUMAN
pepstats	swissprot:S19A3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S19A3_HUMAN
pepwheel	swissprot:S19A3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S19A3_HUMAN
pepwindow	swissprot:S19A3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S19A3_HUMAN
sigcleave	swissprot:S19A3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S19A3_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNJ8_HUMAN	Inward rectifier K(+) channel Kir6.1
# AltName	KCNJ8_HUMAN	Potassium channel, inwardly rectifying subfamily J member 8
# AltName	KCNJ8_HUMAN	uKATP-1
# BioGrid	109966	19
# DISEASE	KCNJ8_HUMAN	Hypertrichotic osteochondrodysplasia (HTOCD) [MIM 239850]  A rare disorder characterized by congenital hypertrichosis, neonatal macrosomia, a distinct osteochondrodysplasia, and cardiomegaly. The hypertrichosis leads to thick scalp hair, which extends onto the forehead, and a general increase in body hair. In addition, macrocephaly and coarse facial features, including a broad nasal bridge, epicanthal folds, a wide mouth, and full lips, can be suggestive of a storage disorder. About half of affected individuals are macrosomic and edematous at birth, whereas in childhood they usually have a muscular appearance with little subcutaneous fat. Thickened calvarium, narrow thorax, wide ribs, flattened or ovoid vertebral bodies, coxa valga, osteopenia, enlarged medullary canals, and metaphyseal widening of long bones have been reported. Cardiac manifestations such as patent ductus arteriosus, ventricular hypertrophy, pulmonary hypertension, and pericardial effusions are present in approximately 80% of cases. Motor development is usually delayed due to hypotonia. Most patients have a mild speech delay, and a small percentage have learning difficulties or intellectual disability. {ECO 0000269|PubMed 24700710}. Note=The disease may be caused by mutations affecting distinct genetic loci, including the gene represented in this entry. 
# DISEASE	KCNJ8_HUMAN	Note=Defects in KCNJ8 may be associated with susceptibility to J-wave syndromes, a group of heart disorders characterized by early repolarization events as indicated by abnormal J-wave manifestation on electrocardiogram (ECG). The J point denotes the junction of the QRS complex and the ST segment on the ECG, marking the end of depolarization and the beginning of repolarization. An abnormal J wave is a deflection with a dome or hump morphology immediately following the QRS complex of the surface ECG. Examples of J-wave disorders are arrhythmias associated with an early repolarization pattern in the inferior or mid to lateral precordial leads, Brugada syndrome, some cases of idiopathic ventricular fibrillation (VF) with an early repolarization pattern in the inferior, inferolateral or global leads, as well as arrhythmias associated with hypothermia. 
# DISEASE	KCNJ8_HUMAN	Sudden infant death syndrome (SIDS) [MIM 272120]  SIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive. {ECO 0000269|PubMed 21836131}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# DrugBank	DB00914	Phenformin
# DrugBank	DB00922	Levosimendan
# DrugBank	DB01016	Glyburide
# DrugBank	DB01154	Thiamylal
# DrugBank	DB01251	Gliquidone
# DrugBank	DB01289	Glisoxepide
# DrugBank	DB01392	Yohimbine
# Ensembl	ENST00000240662	ENSP00000240662; ENSG00000121361
# ExpressionAtlas	Q15842	baseline and differential
# FUNCTION	KCNJ8_HUMAN	This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium (By similarity). {ECO 0000250}. 
# GO_component	GO:0005739	mitochondrion; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008076	voltage-gated potassium channel complex; TAS:ProtInc.
# GO_component	GO:0008282	ATP-sensitive potassium channel complex; IEA:Ensembl.
# GO_component	GO:0030016	myofibril; IEA:Ensembl.
# GO_component	GO:0042383	sarcolemma; IEA:Ensembl.
# GO_function	GO:0005242	inward rectifier potassium channel activity; TAS:ProtInc.
# GO_function	GO:0005524	ATP binding; IEA:Ensembl.
# GO_function	GO:0015272	ATP-activated inward rectifier potassium channel activity; IBA:GO_Central.
# GO_process	GO:0001822	kidney development; IEA:Ensembl.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0007507	heart development; IEA:Ensembl.
# GO_process	GO:0009268	response to pH; IEA:Ensembl.
# GO_process	GO:0010107	potassium ion import; IBA:GO_Central.
# GO_process	GO:0032496	response to lipopolysaccharide; IEA:Ensembl.
# GO_process	GO:0042311	vasodilation; IEA:Ensembl.
# GO_process	GO:0043330	response to exogenous dsRNA; IEA:Ensembl.
# GO_process	GO:0051607	defense response to virus; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0003013	circulatory system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.40.1400	-; 1.
# Genevisible	Q15842	HS
# HGNC	HGNC:6269	KCNJ8
# InterPro	IPR003278	K_chnl_inward-rec_Kir6.1
# InterPro	IPR013518	K_chnl_inward-rec_Kir_cyto
# InterPro	IPR014756	Ig_E-set
# InterPro	IPR016449	K_chnl_inward-rec_Kir
# KEGG_Brite	ko04040	Ion channels
# MIM	239850	phenotype
# MIM	272120	phenotype
# MIM	600935	gene
# Organism	KCNJ8_HUMAN	Homo sapiens (Human)
# Orphanet	130	Brugada syndrome
# Orphanet	1517	Hypertrichotic osteochondrodysplasia, Cantu type
# PANTHER	PTHR11767	PTHR11767
# PIRSF	PIRSF005465	GIRK_kir
# PRINTS	PR01320	KIRCHANNEL
# PRINTS	PR01331	KIR61CHANNEL
# Pfam	PF01007	IRK
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-1296025	ATP sensitive Potassium channels
# RecName	KCNJ8_HUMAN	ATP-sensitive inward rectifier potassium channel 8
# RefSeq	NP_004973	NM_004982.3
# RefSeq	XP_005253415	XM_005253358.4
# RefSeq	XP_016874772	XM_017019283.1
# RefSeq	XP_016874773	XM_017019284.1
# SIMILARITY	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ8 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCNJ8_HUMAN	Membrane; Multi-pass membrane protein. 
# SUPFAM	SSF81296	SSF81296
# TCDB	1.A.2.1.13	inward rectifier k(+) channel (irk-c) family
# TISSUE SPECIFICITY	Predominantly detected in fetal and adult heart. {ECO:0000269|PubMed	9573340}. 
# UCSC	uc001rff	human
# eggNOG	ENOG410XQ62	LUCA
# eggNOG	KOG3827	Eukaryota
BLAST	swissprot:KCNJ8_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNJ8_HUMAN
BioCyc	ZFISH:ENSG00000121361-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000121361-MONOMER
COXPRESdb	3764	http://coxpresdb.jp/data/gene/3764.shtml
CleanEx	HS_KCNJ8	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNJ8
DOI	10.1002/humu.22555	http://dx.doi.org/10.1002/humu.22555
DOI	10.1006/geno.1995.0018	http://dx.doi.org/10.1006/geno.1995.0018
DOI	10.1016/S0378-1119(98)00086-9	http://dx.doi.org/10.1016/S0378-1119(98)00086-9
DOI	10.1016/j.hrthm.2009.12.006	http://dx.doi.org/10.1016/j.hrthm.2009.12.006
DOI	10.1016/j.hrthm.2010.06.016	http://dx.doi.org/10.1016/j.hrthm.2010.06.016
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1161/CIRCGENETICS.111.960195	http://dx.doi.org/10.1161/CIRCGENETICS.111.960195
DrugBank	DB00914	http://www.drugbank.ca/drugs/DB00914
DrugBank	DB00922	http://www.drugbank.ca/drugs/DB00922
DrugBank	DB01016	http://www.drugbank.ca/drugs/DB01016
DrugBank	DB01154	http://www.drugbank.ca/drugs/DB01154
DrugBank	DB01251	http://www.drugbank.ca/drugs/DB01251
DrugBank	DB01289	http://www.drugbank.ca/drugs/DB01289
DrugBank	DB01392	http://www.drugbank.ca/drugs/DB01392
EMBL	BC000544	http://www.ebi.ac.uk/ena/data/view/BC000544
EMBL	D50312	http://www.ebi.ac.uk/ena/data/view/D50312
EMBL	D50315	http://www.ebi.ac.uk/ena/data/view/D50315
Ensembl	ENST00000240662	http://www.ensembl.org/id/ENST00000240662
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0008282	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008282
GO_component	GO:0030016	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030016
GO_component	GO:0042383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042383
GO_function	GO:0005242	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005242
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0015272	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015272
GO_process	GO:0001822	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001822
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0007507	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007507
GO_process	GO:0009268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009268
GO_process	GO:0010107	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010107
GO_process	GO:0032496	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032496
GO_process	GO:0042311	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042311
GO_process	GO:0043330	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043330
GO_process	GO:0051607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051607
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0003013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003013
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.40.1400	http://www.cathdb.info/version/latest/superfamily/2.60.40.1400
GeneCards	KCNJ8	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNJ8
GeneID	3764	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3764
GeneTree	ENSGT00760000118842	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118842
HGNC	HGNC:6269	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6269
HOGENOM	HOG000237325	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237325&db=HOGENOM6
HOVERGEN	HBG006178	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006178&db=HOVERGEN
HPA	HPA031066	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031066
InParanoid	Q15842	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q15842
InterPro	IPR003278	http://www.ebi.ac.uk/interpro/entry/IPR003278
InterPro	IPR013518	http://www.ebi.ac.uk/interpro/entry/IPR013518
InterPro	IPR014756	http://www.ebi.ac.uk/interpro/entry/IPR014756
InterPro	IPR016449	http://www.ebi.ac.uk/interpro/entry/IPR016449
Jabion	3764	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3764
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3764	http://www.genome.jp/dbget-bin/www_bget?hsa:3764
KEGG_Orthology	KO:K05001	http://www.genome.jp/dbget-bin/www_bget?KO:K05001
MIM	239850	http://www.ncbi.nlm.nih.gov/omim/239850
MIM	272120	http://www.ncbi.nlm.nih.gov/omim/272120
MIM	600935	http://www.ncbi.nlm.nih.gov/omim/600935
OMA	AMELQCS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AMELQCS
Orphanet	130	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=130
Orphanet	1517	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1517
OrthoDB	EOG091G08HC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08HC
PANTHER	PTHR11767	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11767
PRINTS	PR01320	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01320
PRINTS	PR01331	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01331
PSORT	swissprot:KCNJ8_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNJ8_HUMAN
PSORT-B	swissprot:KCNJ8_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNJ8_HUMAN
PSORT2	swissprot:KCNJ8_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNJ8_HUMAN
Pfam	PF01007	http://pfam.xfam.org/family/PF01007
PharmGKB	PA30050	http://www.pharmgkb.org/do/serve?objId=PA30050&objCls=Gene
Phobius	swissprot:KCNJ8_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNJ8_HUMAN
PhylomeDB	Q15842	http://phylomedb.org/?seqid=Q15842
ProteinModelPortal	Q15842	http://www.proteinmodelportal.org/query/uniprot/Q15842
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	20153265	http://www.ncbi.nlm.nih.gov/pubmed/20153265
PubMed	20558321	http://www.ncbi.nlm.nih.gov/pubmed/20558321
PubMed	21836131	http://www.ncbi.nlm.nih.gov/pubmed/21836131
PubMed	24700710	http://www.ncbi.nlm.nih.gov/pubmed/24700710
PubMed	8595887	http://www.ncbi.nlm.nih.gov/pubmed/8595887
PubMed	9573340	http://www.ncbi.nlm.nih.gov/pubmed/9573340
Reactome	R-HSA-1296025	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296025
RefSeq	NP_004973	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004973
RefSeq	XP_005253415	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005253415
RefSeq	XP_016874772	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016874772
RefSeq	XP_016874773	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016874773
SMR	Q15842	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q15842
STRING	9606.ENSP00000240662	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000240662&targetmode=cogs
SUPFAM	SSF81296	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81296
TCDB	1.A.2.1.13	http://www.tcdb.org/search/result.php?tc=1.A.2.1.13
UCSC	uc001rff	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001rff&org=rat
UniGene	Hs.102308	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.102308
UniGene	Hs.619408	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.619408
UniGene	Hs.741642	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.741642
UniProtKB	KCNJ8_HUMAN	http://www.uniprot.org/uniprot/KCNJ8_HUMAN
UniProtKB-AC	Q15842	http://www.uniprot.org/uniprot/Q15842
charge	swissprot:KCNJ8_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNJ8_HUMAN
eggNOG	ENOG410XQ62	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ62
eggNOG	KOG3827	http://eggnogapi.embl.de/nog_data/html/tree/KOG3827
epestfind	swissprot:KCNJ8_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNJ8_HUMAN
garnier	swissprot:KCNJ8_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNJ8_HUMAN
helixturnhelix	swissprot:KCNJ8_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNJ8_HUMAN
hmoment	swissprot:KCNJ8_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNJ8_HUMAN
iep	swissprot:KCNJ8_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNJ8_HUMAN
inforesidue	swissprot:KCNJ8_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNJ8_HUMAN
neXtProt	NX_Q15842	http://www.nextprot.org/db/entry/NX_Q15842
octanol	swissprot:KCNJ8_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNJ8_HUMAN
pepcoil	swissprot:KCNJ8_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNJ8_HUMAN
pepdigest	swissprot:KCNJ8_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNJ8_HUMAN
pepinfo	swissprot:KCNJ8_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNJ8_HUMAN
pepnet	swissprot:KCNJ8_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNJ8_HUMAN
pepstats	swissprot:KCNJ8_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNJ8_HUMAN
pepwheel	swissprot:KCNJ8_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNJ8_HUMAN
pepwindow	swissprot:KCNJ8_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNJ8_HUMAN
sigcleave	swissprot:KCNJ8_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNJ8_HUMAN
## Database	ID	URL or Descriptions
# AltName	Placental protein 15 {ECO:0000303|PubMed	3380696}
# BioGrid	115499	34
# CDD	cd00780	NTF2
# ChiTaRS	NUTF2	human
# Ensembl	ENST00000219169	ENSP00000219169; ENSG00000102898
# Ensembl	ENST00000568396	ENSP00000457022; ENSG00000102898
# Ensembl	ENST00000569436	ENSP00000457989; ENSG00000102898
# ExpressionAtlas	P61970	baseline and differential
# FUNCTION	NTF2_HUMAN	Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import. {ECO 0000269|PubMed 10679025, ECO 0000269|PubMed 7744965}. 
# GO_component	GO:0005637	nuclear inner membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005640	nuclear outer membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005654	nucleoplasm; IDA:UniProtKB.
# GO_component	GO:0005829	cytosol; IDA:UniProtKB.
# GO_component	GO:0031965	nuclear membrane; ISS:UniProtKB.
# GO_component	GO:0044613	nuclear pore central transport channel; IEA:Ensembl.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0008320	protein transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0008536	Ran GTPase binding; IDA:UniProtKB.
# GO_process	GO:0000060	protein import into nucleus, translocation; IMP:UniProtKB.
# GO_process	GO:0006606	protein import into nucleus; IDA:UniProtKB.
# GO_process	GO:0006611	protein export from nucleus; IDA:BHF-UCL.
# GO_process	GO:0042307	positive regulation of protein import into nucleus; IEA:Ensembl.
# GO_process	GO:0051028	mRNA transport; IEA:UniProtKB-KW.
# GO_process	GO:0090204	protein localization to nuclear pore; ISS:UniProtKB.
# GO_process	GO:1904046	negative regulation of vascular endothelial growth factor production; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# GOslim_process	GO:0008150	biological_process
# Gene3D	3.10.450.50	-; 1.
# Genevisible	P61970	HS
# HGNC	HGNC:13722	NUTF2
# INTERACTION	NTF2_HUMAN	P37198 NUP62; NbExp=5; IntAct=EBI-591778, EBI-347978; P62826 RAN; NbExp=4; IntAct=EBI-591778, EBI-286642; 
# IntAct	P61970	9
# InterPro	IPR002075	NTF2
# InterPro	IPR018222	Nuclear_transport_factor_2_euk
# InterPro	IPR032710	NTF2-like_dom
# MIM	605813	gene
# Organism	NTF2_HUMAN	Homo sapiens (Human)
# PDB	1GY5	X-ray; 2.30 A; A/B=1-127
# PIR	S00751	S00751
# PROSITE	PS50177	NTF2_DOMAIN
# Pfam	PF02136	NTF2
# Proteomes	UP000005640	Chromosome 16
# RecName	Nuclear transport factor 2 {ECO:0000303|PubMed	7744965}
# RefSeq	NP_001308967	NM_001322038.1
# RefSeq	NP_001308968	NM_001322039.1
# RefSeq	NP_001308969	NM_001322040.1
# RefSeq	NP_001308970	NM_001322041.1
# RefSeq	NP_005787	NM_005796.2
# SIMILARITY	Contains 1 NTF2 domain. {ECO:0000255|PROSITE- ProRule	PRU00137}.
# SUBCELLULAR LOCATION	NTF2_HUMAN	Cytoplasm, cytosol {ECO 0000269|PubMed 10679025, ECO 0000269|PubMed 7744965}. Nucleus outer membrane {ECO 0000250|UniProtKB P61972}. Nucleus, nuclear pore complex {ECO 0000250|UniProtKB P61972}. Nucleus inner membrane {ECO 0000250|UniProtKB P61972}. Nucleus, nucleoplasm {ECO 0000269|PubMed 10679025}. Note=At steady state it is essentially nucleoplasmic, enriched in nucleoplasmic foci. {ECO 0000269|PubMed 10679025}. 
# SUBUNIT	NTF2_HUMAN	Homodimer (PubMed 7744965). Interacts with RAN (GDP-bound form); the interaction is direct and regulates RAN nuclear import (PubMed 10679025). Interacts with the nucleoporins NUP54, NUP58 and NUP62 (via FG repeats); recruits NUTF2 to the nuclear pore complex a step required for NUTF2-mediated GDP-bound RAN nuclear import (PubMed 7744965). Interacts with CAPG; mediates its nuclear import (PubMed 18266911). {ECO 0000269|PubMed 10679025, ECO 0000269|PubMed 18266911, ECO 0000269|PubMed 7744965}. 
# SUPFAM	SSF54427	SSF54427
# UCSC	uc002eup	human
# eggNOG	ENOG4111QUX	LUCA
# eggNOG	KOG2104	Eukaryota
BLAST	swissprot:NTF2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NTF2_HUMAN
BioCyc	ZFISH:ENSG00000102898-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000102898-MONOMER
COXPRESdb	10204	http://coxpresdb.jp/data/gene/10204.shtml
CleanEx	HS_NUTF2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_NUTF2
DIP	DIP-6057N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-6057N
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1083/jcb.129.4.925	http://dx.doi.org/10.1083/jcb.129.4.925
DOI	10.1091/mbc.11.2.703	http://dx.doi.org/10.1091/mbc.11.2.703
DOI	10.1093/nar/16.10.4721	http://dx.doi.org/10.1093/nar/16.10.4721
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1600-0854.2008.00720.x	http://dx.doi.org/10.1111/j.1600-0854.2008.00720.x
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AK311822	http://www.ebi.ac.uk/ena/data/view/AK311822
EMBL	BC002348	http://www.ebi.ac.uk/ena/data/view/BC002348
EMBL	CH471092	http://www.ebi.ac.uk/ena/data/view/CH471092
EMBL	CR456937	http://www.ebi.ac.uk/ena/data/view/CR456937
EMBL	U43939	http://www.ebi.ac.uk/ena/data/view/U43939
EMBL	X07315	http://www.ebi.ac.uk/ena/data/view/X07315
Ensembl	ENST00000219169	http://www.ensembl.org/id/ENST00000219169
Ensembl	ENST00000568396	http://www.ensembl.org/id/ENST00000568396
Ensembl	ENST00000569436	http://www.ensembl.org/id/ENST00000569436
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005637	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005637
GO_component	GO:0005640	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005640
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0031965	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031965
GO_component	GO:0044613	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044613
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0008320	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008320
GO_function	GO:0008536	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008536
GO_process	GO:0000060	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000060
GO_process	GO:0006606	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006606
GO_process	GO:0006611	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006611
GO_process	GO:0042307	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042307
GO_process	GO:0051028	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051028
GO_process	GO:0090204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090204
GO_process	GO:1904046	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1904046
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	3.10.450.50	http://www.cathdb.info/version/latest/superfamily/3.10.450.50
GeneCards	NUTF2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=NUTF2
GeneID	10204	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10204
GeneTree	ENSGT00510000047030	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00510000047030
HGNC	HGNC:13722	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13722
HOGENOM	HOG000197024	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000197024&db=HOGENOM6
HOVERGEN	HBG025070	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG025070&db=HOVERGEN
HPA	HPA040915	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA040915
HPA	HPA040956	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA040956
InParanoid	P61970	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P61970
IntAct	P61970	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P61970*
InterPro	IPR002075	http://www.ebi.ac.uk/interpro/entry/IPR002075
InterPro	IPR018222	http://www.ebi.ac.uk/interpro/entry/IPR018222
InterPro	IPR032710	http://www.ebi.ac.uk/interpro/entry/IPR032710
Jabion	10204	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10204
KEGG_Gene	hsa:10204	http://www.genome.jp/dbget-bin/www_bget?hsa:10204
MIM	605813	http://www.ncbi.nlm.nih.gov/omim/605813
MINT	MINT-5004387	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5004387
OMA	LSLHDCD	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LSLHDCD
OrthoDB	EOG091G0SZN	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0SZN
PDB	1GY5	http://www.ebi.ac.uk/pdbe-srv/view/entry/1GY5
PDBsum	1GY5	http://www.ebi.ac.uk/pdbsum/1GY5
PROSITE	PS50177	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50177
PSORT	swissprot:NTF2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NTF2_HUMAN
PSORT-B	swissprot:NTF2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NTF2_HUMAN
PSORT2	swissprot:NTF2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NTF2_HUMAN
Pfam	PF02136	http://pfam.xfam.org/family/PF02136
PharmGKB	PA38365	http://www.pharmgkb.org/do/serve?objId=PA38365&objCls=Gene
Phobius	swissprot:NTF2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NTF2_HUMAN
PhylomeDB	P61970	http://phylomedb.org/?seqid=P61970
ProteinModelPortal	P61970	http://www.proteinmodelportal.org/query/uniprot/P61970
PubMed	10679025	http://www.ncbi.nlm.nih.gov/pubmed/10679025
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18266911	http://www.ncbi.nlm.nih.gov/pubmed/18266911
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	3380696	http://www.ncbi.nlm.nih.gov/pubmed/3380696
PubMed	7744965	http://www.ncbi.nlm.nih.gov/pubmed/7744965
RefSeq	NP_001308967	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001308967
RefSeq	NP_001308968	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001308968
RefSeq	NP_001308969	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001308969
RefSeq	NP_001308970	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001308970
RefSeq	NP_005787	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005787
SMR	P61970	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P61970
STRING	9606.ENSP00000219169	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000219169&targetmode=cogs
SUPFAM	SSF54427	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54427
UCSC	uc002eup	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002eup&org=rat
UniGene	Hs.356630	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.356630
UniProtKB	NTF2_HUMAN	http://www.uniprot.org/uniprot/NTF2_HUMAN
UniProtKB-AC	P61970	http://www.uniprot.org/uniprot/P61970
charge	swissprot:NTF2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NTF2_HUMAN
eggNOG	ENOG4111QUX	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111QUX
eggNOG	KOG2104	http://eggnogapi.embl.de/nog_data/html/tree/KOG2104
epestfind	swissprot:NTF2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NTF2_HUMAN
garnier	swissprot:NTF2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NTF2_HUMAN
helixturnhelix	swissprot:NTF2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NTF2_HUMAN
hmoment	swissprot:NTF2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NTF2_HUMAN
iep	swissprot:NTF2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NTF2_HUMAN
inforesidue	swissprot:NTF2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NTF2_HUMAN
neXtProt	NX_P61970	http://www.nextprot.org/db/entry/NX_P61970
octanol	swissprot:NTF2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NTF2_HUMAN
pepcoil	swissprot:NTF2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NTF2_HUMAN
pepdigest	swissprot:NTF2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NTF2_HUMAN
pepinfo	swissprot:NTF2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NTF2_HUMAN
pepnet	swissprot:NTF2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NTF2_HUMAN
pepstats	swissprot:NTF2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NTF2_HUMAN
pepwheel	swissprot:NTF2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NTF2_HUMAN
pepwindow	swissprot:NTF2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NTF2_HUMAN
sigcleave	swissprot:NTF2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NTF2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ABCD3_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P28288-1; Sequence=Displayed; Name=2; IsoId=P28288-2; Sequence=VSP_031189; Note=No experimental confirmation available.; Name=3; IsoId=P28288-3; Sequence=VSP_031187, VSP_031188; 
# AltName	ABCD3_HUMAN	70 kDa peroxisomal membrane protein
# BioGrid	111783	71
# CCDS	CCDS44175	-. [P28288-3]
# CCDS	CCDS749	-. [P28288-1]
# ChiTaRS	ABCD3	human
# DISEASE	ABCD3_HUMAN	Congenital bile acid synthesis defect 5 (CBAS5) [MIM 616278]  An autosomal recessive disorder characterized by hepatosplenomegaly, hepatic fibrosis, progressive liver failure, and accumulation of peroxisomal C27-bile acid intermediates in plasma. {ECO 0000269|PubMed 25168382}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000315713	ENSP00000326880; ENSG00000117528. [P28288-3]
# Ensembl	ENST00000370214	ENSP00000359233; ENSG00000117528. [P28288-1]
# FUNCTION	ABCD3_HUMAN	Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis (PubMed 25168382). The nucleotide-binding fold acts as an ATP- binding subunit with ATPase activity (PubMed 11248239). {ECO 0000269|PubMed 11248239, ECO 0000269|PubMed 25168382}. 
# GO_component	GO:0005743	mitochondrial inner membrane; IEA:Ensembl.
# GO_component	GO:0005777	peroxisome; IDA:UniProtKB.
# GO_component	GO:0005778	peroxisomal membrane; IDA:UniProtKB.
# GO_component	GO:0005782	peroxisomal matrix; IDA:UniProtKB.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_function	GO:0005324	long-chain fatty acid transporter activity; TAS:Reactome.
# GO_function	GO:0005524	ATP binding; IDA:UniProtKB.
# GO_function	GO:0016887	ATPase activity; IDA:UniProtKB.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro.
# GO_function	GO:0042803	protein homodimerization activity; IDA:UniProtKB.
# GO_process	GO:0006633	fatty acid biosynthetic process; IMP:UniProtKB.
# GO_process	GO:0006635	fatty acid beta-oxidation; IGI:UniProtKB.
# GO_process	GO:0007031	peroxisome organization; IDA:UniProtKB.
# GO_process	GO:0014070	response to organic cyclic compound; IEA:Ensembl.
# GO_process	GO:0015910	peroxisomal long-chain fatty acid import; IEA:InterPro.
# GO_process	GO:0042493	response to drug; IEA:Ensembl.
# GO_process	GO:0042760	very long-chain fatty acid catabolic process; IGI:UniProtKB.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005777	peroxisome
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009056	catabolic process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 1.
# Genevisible	P28288	HS
# HGNC	HGNC:67	ABCD3
# INTERACTION	ABCD3_HUMAN	P33897 ABCD1; NbExp=2; IntAct=EBI-80992, EBI-81045; P40855 PEX19; NbExp=4; IntAct=EBI-80992, EBI-594747; 
# IntAct	P28288	38
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR005283	FA_transporter
# InterPro	IPR011527	ABC1_TM_dom
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR027417	P-loop_NTPase
# InterPro	IPR031241	ABCD3
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko02010	ABC transporters
# KEGG_Pathway	ko04146	Peroxisome
# MIM	170995	gene
# MIM	616278	phenotype
# MISCELLANEOUS	ABCD3_HUMAN	Mutation in ABCD3 have been found in two individuals affected by Zellweger syndrome. However, the role of ABCD3 in the causation of Zellweger syndrome remains uncertain. 
# Organism	ABCD3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11384:SF34	PTHR11384:SF34
# PIR	S20313	S20313
# PROSITE	PS00211	ABC_TRANSPORTER_1
# PROSITE	PS50893	ABC_TRANSPORTER_2
# PROSITE	PS50929	ABC_TM1F
# Pfam	PF00005	ABC_tran
# Pfam	PF06472	ABC_membrane_2
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-1369062	ABC transporters in lipid homeostasis
# RecName	ABCD3_HUMAN	ATP-binding cassette sub-family D member 3
# RefSeq	NP_001116146	NM_001122674.1. [P28288-3]
# RefSeq	NP_002849	NM_002858.3. [P28288-1]
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule	PRU00441}. 
# SIMILARITY	Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA
# SUBCELLULAR LOCATION	ABCD3_HUMAN	Peroxisome membrane {ECO 0000269|PubMed 10704444}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00441, ECO 0000269|PubMed 10704444}. 
# SUBUNIT	ABCD3_HUMAN	Can form heterodimers with ABCD1/ALD and ABCD2/ALDR. Dimerization is necessary to form an active transporter. Interacts with PEX19. {ECO 0000269|PubMed 10551832, ECO 0000269|PubMed 10704444, ECO 0000269|PubMed 10777694}. 
# SUPFAM	SSF52540	SSF52540
# SUPFAM	SSF90123	SSF90123
# TCDB	3.A.1.203	the atp-binding cassette (abc) superfamily
# TIGRFAMs	TIGR00954	3a01203
# UCSC	uc001dqm	human. [P28288-1]
# WEB RESOURCE	ABCD3_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=P28288";
# eggNOG	COG4178	LUCA
# eggNOG	KOG0064	Eukaryota
BLAST	swissprot:ABCD3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCD3_HUMAN
BioCyc	ZFISH:ENSG00000117528-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000117528-MONOMER
COXPRESdb	5825	http://coxpresdb.jp/data/gene/5825.shtml
CleanEx	HS_ABCD3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCD3
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/bbrc.2000.2572	http://dx.doi.org/10.1006/bbrc.2000.2572
DOI	10.1006/geno.1997.5177	http://dx.doi.org/10.1006/geno.1997.5177
DOI	10.1016/0167-4781(92)90510-7	http://dx.doi.org/10.1016/0167-4781(92)90510-7
DOI	10.1016/S0014-5793(01)02235-9	http://dx.doi.org/10.1016/S0014-5793(01)02235-9
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng0492-16	http://dx.doi.org/10.1038/ng0492-16
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1074/jbc.274.46.32738	http://dx.doi.org/10.1074/jbc.274.46.32738
DOI	10.1083/jcb.148.5.931	http://dx.doi.org/10.1083/jcb.148.5.931
DOI	10.1093/hmg/ddu448	http://dx.doi.org/10.1093/hmg/ddu448
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AC093117	http://www.ebi.ac.uk/ena/data/view/AC093117
EMBL	AC118469	http://www.ebi.ac.uk/ena/data/view/AC118469
EMBL	AL138758	http://www.ebi.ac.uk/ena/data/view/AL138758
EMBL	BC009712	http://www.ebi.ac.uk/ena/data/view/BC009712
EMBL	BC068509	http://www.ebi.ac.uk/ena/data/view/BC068509
EMBL	BT006644	http://www.ebi.ac.uk/ena/data/view/BT006644
EMBL	CH471097	http://www.ebi.ac.uk/ena/data/view/CH471097
EMBL	CH471097	http://www.ebi.ac.uk/ena/data/view/CH471097
EMBL	CH471097	http://www.ebi.ac.uk/ena/data/view/CH471097
EMBL	CH471097	http://www.ebi.ac.uk/ena/data/view/CH471097
EMBL	M81182	http://www.ebi.ac.uk/ena/data/view/M81182
EMBL	X58528	http://www.ebi.ac.uk/ena/data/view/X58528
EMBL	X83467	http://www.ebi.ac.uk/ena/data/view/X83467
EMBL	X83468	http://www.ebi.ac.uk/ena/data/view/X83468
EMBL	X83469	http://www.ebi.ac.uk/ena/data/view/X83469
EMBL	X83470	http://www.ebi.ac.uk/ena/data/view/X83470
EMBL	X83471	http://www.ebi.ac.uk/ena/data/view/X83471
EMBL	X83472	http://www.ebi.ac.uk/ena/data/view/X83472
EMBL	X83473	http://www.ebi.ac.uk/ena/data/view/X83473
EMBL	X83474	http://www.ebi.ac.uk/ena/data/view/X83474
EMBL	X83475	http://www.ebi.ac.uk/ena/data/view/X83475
EMBL	X83476	http://www.ebi.ac.uk/ena/data/view/X83476
EMBL	X83477	http://www.ebi.ac.uk/ena/data/view/X83477
EMBL	X83478	http://www.ebi.ac.uk/ena/data/view/X83478
EMBL	X83479	http://www.ebi.ac.uk/ena/data/view/X83479
EMBL	X83480	http://www.ebi.ac.uk/ena/data/view/X83480
EMBL	X83481	http://www.ebi.ac.uk/ena/data/view/X83481
EMBL	X83482	http://www.ebi.ac.uk/ena/data/view/X83482
EMBL	X83483	http://www.ebi.ac.uk/ena/data/view/X83483
EMBL	X83484	http://www.ebi.ac.uk/ena/data/view/X83484
EMBL	X83485	http://www.ebi.ac.uk/ena/data/view/X83485
EMBL	X83486	http://www.ebi.ac.uk/ena/data/view/X83486
EMBL	X83487	http://www.ebi.ac.uk/ena/data/view/X83487
EMBL	X83488	http://www.ebi.ac.uk/ena/data/view/X83488
EMBL	X83489	http://www.ebi.ac.uk/ena/data/view/X83489
Ensembl	ENST00000315713	http://www.ensembl.org/id/ENST00000315713
Ensembl	ENST00000370214	http://www.ensembl.org/id/ENST00000370214
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005777	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005777
GO_component	GO:0005778	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005778
GO_component	GO:0005782	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005782
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0005324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005324
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_process	GO:0006633	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006633
GO_process	GO:0006635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006635
GO_process	GO:0007031	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007031
GO_process	GO:0014070	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014070
GO_process	GO:0015910	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015910
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0042760	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042760
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005777	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005777
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCD3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCD3
GeneID	5825	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5825
GeneTree	ENSGT00390000003950	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000003950
HGNC	HGNC:67	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:67
HOGENOM	HOG000206081	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000206081&db=HOGENOM6
HOVERGEN	HBG050438	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050438&db=HOVERGEN
HPA	CAB032516	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB032516
HPA	CAB075749	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB075749
HPA	HPA032026	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA032026
HPA	HPA032027	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA032027
InParanoid	P28288	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P28288
IntAct	P28288	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P28288*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR005283	http://www.ebi.ac.uk/interpro/entry/IPR005283
InterPro	IPR011527	http://www.ebi.ac.uk/interpro/entry/IPR011527
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
InterPro	IPR031241	http://www.ebi.ac.uk/interpro/entry/IPR031241
Jabion	5825	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=5825
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:5825	http://www.genome.jp/dbget-bin/www_bget?hsa:5825
KEGG_Orthology	KO:K05677	http://www.genome.jp/dbget-bin/www_bget?KO:K05677
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
KEGG_Pathway	ko04146	http://www.genome.jp/kegg-bin/show_pathway?ko04146
MIM	170995	http://www.ncbi.nlm.nih.gov/omim/170995
MIM	616278	http://www.ncbi.nlm.nih.gov/omim/616278
MINT	MINT-3010926	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3010926
OMA	SMMAYLI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SMMAYLI
OrthoDB	EOG091G04M1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G04M1
PANTHER	PTHR11384:SF34	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11384:SF34
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PROSITE	PS50929	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929
PSORT	swissprot:ABCD3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCD3_HUMAN
PSORT-B	swissprot:ABCD3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCD3_HUMAN
PSORT2	swissprot:ABCD3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCD3_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF06472	http://pfam.xfam.org/family/PF06472
PharmGKB	PA24402	http://www.pharmgkb.org/do/serve?objId=PA24402&objCls=Gene
Phobius	swissprot:ABCD3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCD3_HUMAN
PhylomeDB	P28288	http://phylomedb.org/?seqid=P28288
ProteinModelPortal	P28288	http://www.proteinmodelportal.org/query/uniprot/P28288
PubMed	10551832	http://www.ncbi.nlm.nih.gov/pubmed/10551832
PubMed	10704444	http://www.ncbi.nlm.nih.gov/pubmed/10704444
PubMed	10777694	http://www.ncbi.nlm.nih.gov/pubmed/10777694
PubMed	11248239	http://www.ncbi.nlm.nih.gov/pubmed/11248239
PubMed	1301993	http://www.ncbi.nlm.nih.gov/pubmed/1301993
PubMed	1536884	http://www.ncbi.nlm.nih.gov/pubmed/1536884
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25168382	http://www.ncbi.nlm.nih.gov/pubmed/25168382
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	9521874	http://www.ncbi.nlm.nih.gov/pubmed/9521874
Reactome	R-HSA-1369062	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1369062
RefSeq	NP_001116146	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001116146
RefSeq	NP_002849	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002849
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
STRING	9606.ENSP00000359233	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000359233&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
SUPFAM	SSF90123	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123
TCDB	3.A.1.203	http://www.tcdb.org/search/result.php?tc=3.A.1.203
TIGRFAMs	TIGR00954	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00954
UCSC	uc001dqm	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001dqm&org=rat
UniGene	Hs.700576	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.700576
UniProtKB	ABCD3_HUMAN	http://www.uniprot.org/uniprot/ABCD3_HUMAN
UniProtKB-AC	P28288	http://www.uniprot.org/uniprot/P28288
charge	swissprot:ABCD3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCD3_HUMAN
eggNOG	COG4178	http://eggnogapi.embl.de/nog_data/html/tree/COG4178
eggNOG	KOG0064	http://eggnogapi.embl.de/nog_data/html/tree/KOG0064
epestfind	swissprot:ABCD3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCD3_HUMAN
garnier	swissprot:ABCD3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCD3_HUMAN
helixturnhelix	swissprot:ABCD3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCD3_HUMAN
hmoment	swissprot:ABCD3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCD3_HUMAN
iep	swissprot:ABCD3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCD3_HUMAN
inforesidue	swissprot:ABCD3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCD3_HUMAN
neXtProt	NX_P28288	http://www.nextprot.org/db/entry/NX_P28288
octanol	swissprot:ABCD3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCD3_HUMAN
pepcoil	swissprot:ABCD3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCD3_HUMAN
pepdigest	swissprot:ABCD3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCD3_HUMAN
pepinfo	swissprot:ABCD3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCD3_HUMAN
pepnet	swissprot:ABCD3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCD3_HUMAN
pepstats	swissprot:ABCD3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCD3_HUMAN
pepwheel	swissprot:ABCD3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCD3_HUMAN
pepwindow	swissprot:ABCD3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCD3_HUMAN
sigcleave	swissprot:ABCD3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCD3_HUMAN
## Database	ID	URL or Descriptions
# AltName	ST20_HUMAN	Human cervical cancer suppressor gene 1 protein
# Ensembl	ENST00000478497	ENSP00000453502; ENSG00000180953
# Ensembl	ENST00000485386	ENSP00000453693; ENSG00000180953
# Ensembl	ENST00000562759	ENSP00000457965; ENSG00000180953
# FUNCTION	ST20_HUMAN	May act as a tumor suppressor. Promotes apoptosis of cancer cells. {ECO 0000269|PubMed 11857354}. 
# GO_component	GO:0005741	mitochondrial outer membrane; IBA:GO_Central.
# GO_function	GO:0015267	channel activity; IBA:GO_Central.
# GO_function	GO:0042803	protein homodimerization activity; IBA:GO_Central.
# GO_function	GO:0046982	protein heterodimerization activity; IBA:GO_Central.
# GO_process	GO:0001836	release of cytochrome c from mitochondria; IBA:GO_Central.
# GO_process	GO:0008053	mitochondrial fusion; IBA:GO_Central.
# GO_process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage; IBA:GO_Central.
# GO_process	GO:0043065	positive regulation of apoptotic process; IBA:GO_Central.
# GO_process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007005	mitochondrion organization
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0061024	membrane organization
# Genevisible	Q9HBF5	HS
# HGNC	HGNC:33520	ST20
# InterPro	IPR026298	Blc2_fam
# InterPro	IPR026301	ST20
# Organism	ST20_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11256	PTHR11256
# PANTHER	PTHR11256:SF2	PTHR11256:SF2
# Proteomes	UP000005640	Chromosome 15
# RecName	ST20_HUMAN	Suppressor of tumorigenicity 20 protein
# RefSeq	NP_001094349	NM_001100879.1
# RefSeq	NP_001094350	NM_001100880.2
# RefSeq	NP_001186686	NM_001199757.1
# TISSUE SPECIFICITY	Expressed in leukocytes, lung, spleen, liver, heart, kidney, muscle and uterine cervix. Down-regulated in cervical cancer. {ECO:0000269|PubMed	11857354}.
# UCSC	uc002bez	human
# eggNOG	ENOG410KC8Y	Eukaryota
# eggNOG	ENOG4110P7P	LUCA
BLAST	swissprot:ST20_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ST20_HUMAN
BioCyc	ZFISH:ENSG00000180953-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000180953-MONOMER
COXPRESdb	400410	http://coxpresdb.jp/data/gene/400410.shtml
CleanEx	HS_ST20	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ST20
DOI	10.1002/ijc.10124	http://dx.doi.org/10.1002/ijc.10124
DOI	10.1038/nature04601	http://dx.doi.org/10.1038/nature04601
EMBL	AC015871	http://www.ebi.ac.uk/ena/data/view/AC015871
EMBL	AF249277	http://www.ebi.ac.uk/ena/data/view/AF249277
Ensembl	ENST00000478497	http://www.ensembl.org/id/ENST00000478497
Ensembl	ENST00000485386	http://www.ensembl.org/id/ENST00000485386
Ensembl	ENST00000562759	http://www.ensembl.org/id/ENST00000562759
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005741	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005741
GO_function	GO:0015267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015267
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_function	GO:0046982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046982
GO_process	GO:0001836	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001836
GO_process	GO:0008053	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008053
GO_process	GO:0008630	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008630
GO_process	GO:0043065	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043065
GO_process	GO:0097192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097192
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007005
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
GeneCards	ST20	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ST20
GeneID	400410	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=400410
GeneTree	ENSGT00510000048456	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00510000048456
H-InvDB	HIX0038090	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0038090
HGNC	HGNC:33520	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:33520
HOGENOM	HOG000169466	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000169466&db=HOGENOM6
InParanoid	Q9HBF5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9HBF5
InterPro	IPR026298	http://www.ebi.ac.uk/interpro/entry/IPR026298
InterPro	IPR026301	http://www.ebi.ac.uk/interpro/entry/IPR026301
Jabion	400410	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=400410
KEGG_Gene	hsa:400410	http://www.genome.jp/dbget-bin/www_bget?hsa:400410
OrthoDB	EOG091G10IK	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G10IK
PANTHER	PTHR11256	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11256
PANTHER	PTHR11256:SF2	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11256:SF2
PSORT	swissprot:ST20_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ST20_HUMAN
PSORT-B	swissprot:ST20_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ST20_HUMAN
PSORT2	swissprot:ST20_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ST20_HUMAN
PharmGKB	PA162404859	http://www.pharmgkb.org/do/serve?objId=PA162404859&objCls=Gene
Phobius	swissprot:ST20_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ST20_HUMAN
PhylomeDB	Q9HBF5	http://phylomedb.org/?seqid=Q9HBF5
ProteinModelPortal	Q9HBF5	http://www.proteinmodelportal.org/query/uniprot/Q9HBF5
PubMed	11857354	http://www.ncbi.nlm.nih.gov/pubmed/11857354
PubMed	16572171	http://www.ncbi.nlm.nih.gov/pubmed/16572171
RefSeq	NP_001094349	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001094349
RefSeq	NP_001094350	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001094350
RefSeq	NP_001186686	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001186686
STRING	9606.ENSP00000453502	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000453502&targetmode=cogs
UCSC	uc002bez	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002bez&org=rat
UniGene	Hs.729127	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.729127
UniProtKB	ST20_HUMAN	http://www.uniprot.org/uniprot/ST20_HUMAN
UniProtKB-AC	Q9HBF5	http://www.uniprot.org/uniprot/Q9HBF5
charge	swissprot:ST20_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ST20_HUMAN
eggNOG	ENOG410KC8Y	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410KC8Y
eggNOG	ENOG4110P7P	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110P7P
epestfind	swissprot:ST20_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ST20_HUMAN
garnier	swissprot:ST20_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ST20_HUMAN
helixturnhelix	swissprot:ST20_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ST20_HUMAN
hmoment	swissprot:ST20_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ST20_HUMAN
iep	swissprot:ST20_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ST20_HUMAN
inforesidue	swissprot:ST20_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ST20_HUMAN
neXtProt	NX_Q9HBF5	http://www.nextprot.org/db/entry/NX_Q9HBF5
octanol	swissprot:ST20_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ST20_HUMAN
pepcoil	swissprot:ST20_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ST20_HUMAN
pepdigest	swissprot:ST20_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ST20_HUMAN
pepinfo	swissprot:ST20_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ST20_HUMAN
pepnet	swissprot:ST20_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ST20_HUMAN
pepstats	swissprot:ST20_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ST20_HUMAN
pepwheel	swissprot:ST20_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ST20_HUMAN
pepwindow	swissprot:ST20_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ST20_HUMAN
sigcleave	swissprot:ST20_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ST20_HUMAN
## Database	ID	URL or Descriptions
# AltName	Solute carrier family 25 member 7 {ECO:0000303|PubMed	23266187}
# AltName	Thermogenin {ECO:0000250|UniProtKB	P04575}
# BioGrid	113197	3
# ENZYME REGULATION	Has no constitutive proton transporter activity and has to be activated by long-chain fatty acids/LCFAs. Inhibited by purine nucleotides. Both purine nucleotides and LCFAs bind the cytosolic side of the transporter and directly compete to activate or inhibit it. Activated by noradrenaline and reactive oxygen species. {ECO:0000250|UniProtKB	P12242}. 
# Ensembl	ENST00000262999	ENSP00000262999; ENSG00000109424
# FUNCTION	UCP1_HUMAN	Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane (PubMed 24196960). However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria (By similarity). {ECO 0000250|UniProtKB P12242, ECO 0000269|PubMed 24196960}. 
# GO_component	GO:0005739	mitochondrion; IDA:MGI.
# GO_component	GO:0005743	mitochondrial inner membrane; ISS:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0017077	oxidative phosphorylation uncoupler activity; ISS:UniProtKB.
# GO_function	GO:0022857	transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0032555	purine ribonucleotide binding; ISS:UniProtKB.
# GO_function	GO:0036041	long-chain fatty acid binding; ISS:UniProtKB.
# GO_function	GO:1901612	cardiolipin binding; ISS:UniProtKB.
# GO_process	GO:0006357	regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
# GO_process	GO:0009266	response to temperature stimulus; ISS:UniProtKB.
# GO_process	GO:0015992	proton transport; IDA:UniProtKB.
# GO_process	GO:0031667	response to nutrient levels; ISS:UniProtKB.
# GO_process	GO:0032870	cellular response to hormone stimulus; ISS:UniProtKB.
# GO_process	GO:0034614	cellular response to reactive oxygen species; ISS:UniProtKB.
# GO_process	GO:0050873	brown fat cell differentiation; ISS:HGNC.
# GO_process	GO:0071398	cellular response to fatty acid; ISS:UniProtKB.
# GO_process	GO:1903426	regulation of reactive oxygen species biosynthetic process; ISS:UniProtKB.
# GO_process	GO:1990542	mitochondrial transmembrane transport; ISS:UniProtKB.
# GO_process	GO:1990845	adaptive thermogenesis; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008289	lipid binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.50.40.10	-; 1.
# Genevisible	P25874	HS
# HGNC	HGNC:12517	UCP1
# InterPro	IPR002030	Mit_uncoupling
# InterPro	IPR018108	Mitochondrial_sb/sol_carrier
# InterPro	IPR023395	Mt_carrier_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko03320	PPAR signaling pathway
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	113730	gene
# Organism	UCP1_HUMAN	Homo sapiens (Human)
# PIR	G01858	G01858
# PRINTS	PR00784	MTUNCOUPLING
# PROSITE	PS50920	SOLCAR; 3
# PTM	UCP1_HUMAN	May undergo sulfenylation upon cold exposure. May increase the sensitivity of UCP1 thermogenic function to the activation by noradrenaline probably through structural effects. {ECO 0000250|UniProtKB P12242}. 
# PTM	UCP1_HUMAN	May undergo ubiquitin-mediated proteasomal degradation. {ECO 0000250|UniProtKB P04633}. 
# Pfam	PF00153	Mito_carr; 3
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-167826	The fatty acid cycling model
# Reactome	R-HSA-167827	The proton buffering model
# RecName	Mitochondrial brown fat uncoupling protein 1 {ECO	0000305}
# RefSeq	NP_068605	NM_021833.4
# SIMILARITY	Belongs to the mitochondrial carrier (TC 2.A.29) family. {ECO	0000305}. 
# SIMILARITY	Contains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule	PRU00282}.
# SUBCELLULAR LOCATION	UCP1_HUMAN	Mitochondrion inner membrane {ECO 0000250|UniProtKB P12242}; Multi-pass membrane protein {ECO 0000250|UniProtKB P04633}. 
# SUBUNIT	UCP1_HUMAN	Most probably functions as a monomer. Binds one purine nucleotide per monomer (By similarity). However, has also been suggested to function as a homodimer or a homotetramer (PubMed 24196960). Tightly associates with cardiolipin in the mitochondrion inner membrane; may stabilize and regulate its activity (PubMed 24196960). {ECO 0000250|UniProtKB W5PSH7, ECO 0000269|PubMed 24196960}. 
# SUPFAM	SSF103506	SSF103506
# TCDB	2.A.29.3	the mitochondrial carrier (mc) family
# TISSUE SPECIFICITY	Brown adipose tissue. {ECO:0000269|PubMed	3165741}. 
# UCSC	uc011chj	human
# eggNOG	ENOG410XRV1	LUCA
# eggNOG	KOG0753	Eukaryota
BLAST	swissprot:UCP1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:UCP1_HUMAN
BioCyc	ZFISH:ENSG00000109424-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000109424-MONOMER
COXPRESdb	7350	http://coxpresdb.jp/data/gene/7350.shtml
CleanEx	HS_UCP1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_UCP1
DOI	10.1002/jcb.240430306	http://dx.doi.org/10.1002/jcb.240430306
DOI	10.1007/s00109-003-0431-1	http://dx.doi.org/10.1007/s00109-003-0431-1
DOI	10.1007/s001250051629	http://dx.doi.org/10.1007/s001250051629
DOI	10.1016/j.mam.2012.05.005	http://dx.doi.org/10.1016/j.mam.2012.05.005
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1042/cs0750021	http://dx.doi.org/10.1042/cs0750021
DOI	10.1074/jbc.M113.509935	http://dx.doi.org/10.1074/jbc.M113.509935
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC108019	http://www.ebi.ac.uk/ena/data/view/AC108019
EMBL	BC069556	http://www.ebi.ac.uk/ena/data/view/BC069556
EMBL	BC098168	http://www.ebi.ac.uk/ena/data/view/BC098168
EMBL	BC098258	http://www.ebi.ac.uk/ena/data/view/BC098258
EMBL	U28480	http://www.ebi.ac.uk/ena/data/view/U28480
EMBL	X51952	http://www.ebi.ac.uk/ena/data/view/X51952
EMBL	X51953	http://www.ebi.ac.uk/ena/data/view/X51953
EMBL	X51954	http://www.ebi.ac.uk/ena/data/view/X51954
EMBL	X51955	http://www.ebi.ac.uk/ena/data/view/X51955
Ensembl	ENST00000262999	http://www.ensembl.org/id/ENST00000262999
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0017077	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017077
GO_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GO_function	GO:0032555	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032555
GO_function	GO:0036041	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036041
GO_function	GO:1901612	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901612
GO_process	GO:0006357	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006357
GO_process	GO:0009266	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009266
GO_process	GO:0015992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992
GO_process	GO:0031667	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031667
GO_process	GO:0032870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032870
GO_process	GO:0034614	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034614
GO_process	GO:0050873	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050873
GO_process	GO:0071398	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071398
GO_process	GO:1903426	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903426
GO_process	GO:1990542	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990542
GO_process	GO:1990845	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990845
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.50.40.10	http://www.cathdb.info/version/latest/superfamily/1.50.40.10
GeneCards	UCP1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=UCP1
GeneID	7350	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7350
GeneTree	ENSGT00760000119170	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119170
HGNC	HGNC:12517	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:12517
HOGENOM	HOG000165140	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000165140&db=HOGENOM6
HOVERGEN	HBG009528	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG009528&db=HOVERGEN
HPA	CAB037199	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB037199
InParanoid	P25874	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25874
InterPro	IPR002030	http://www.ebi.ac.uk/interpro/entry/IPR002030
InterPro	IPR018108	http://www.ebi.ac.uk/interpro/entry/IPR018108
InterPro	IPR023395	http://www.ebi.ac.uk/interpro/entry/IPR023395
Jabion	7350	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7350
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:7350	http://www.genome.jp/dbget-bin/www_bget?hsa:7350
KEGG_Orthology	KO:K08769	http://www.genome.jp/dbget-bin/www_bget?KO:K08769
KEGG_Pathway	ko03320	http://www.genome.jp/kegg-bin/show_pathway?ko03320
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	113730	http://www.ncbi.nlm.nih.gov/omim/113730
OMA	KMFTNEG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KMFTNEG
OrthoDB	EOG091G0BQ7	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0BQ7
PRINTS	PR00784	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00784
PROSITE	PS50920	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50920
PSORT	swissprot:UCP1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:UCP1_HUMAN
PSORT-B	swissprot:UCP1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:UCP1_HUMAN
PSORT2	swissprot:UCP1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:UCP1_HUMAN
Pfam	PF00153	http://pfam.xfam.org/family/PF00153
PharmGKB	PA37164	http://www.pharmgkb.org/do/serve?objId=PA37164&objCls=Gene
Phobius	swissprot:UCP1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:UCP1_HUMAN
PhylomeDB	P25874	http://phylomedb.org/?seqid=P25874
ProteinModelPortal	P25874	http://www.proteinmodelportal.org/query/uniprot/P25874
PubMed	11317671	http://www.ncbi.nlm.nih.gov/pubmed/11317671
PubMed	12756473	http://www.ncbi.nlm.nih.gov/pubmed/12756473
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	23266187	http://www.ncbi.nlm.nih.gov/pubmed/23266187
PubMed	2380264	http://www.ncbi.nlm.nih.gov/pubmed/2380264
PubMed	24196960	http://www.ncbi.nlm.nih.gov/pubmed/24196960
PubMed	3165741	http://www.ncbi.nlm.nih.gov/pubmed/3165741
Reactome	R-HSA-167826	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-167826
Reactome	R-HSA-167827	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-167827
RefSeq	NP_068605	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_068605
STRING	9606.ENSP00000262999	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000262999&targetmode=cogs
SUPFAM	SSF103506	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103506
TCDB	2.A.29.3	http://www.tcdb.org/search/result.php?tc=2.A.29.3
UCSC	uc011chj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc011chj&org=rat
UniGene	Hs.249211	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.249211
UniProtKB	UCP1_HUMAN	http://www.uniprot.org/uniprot/UCP1_HUMAN
UniProtKB-AC	P25874	http://www.uniprot.org/uniprot/P25874
charge	swissprot:UCP1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:UCP1_HUMAN
eggNOG	ENOG410XRV1	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRV1
eggNOG	KOG0753	http://eggnogapi.embl.de/nog_data/html/tree/KOG0753
epestfind	swissprot:UCP1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:UCP1_HUMAN
garnier	swissprot:UCP1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:UCP1_HUMAN
helixturnhelix	swissprot:UCP1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:UCP1_HUMAN
hmoment	swissprot:UCP1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:UCP1_HUMAN
iep	swissprot:UCP1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:UCP1_HUMAN
inforesidue	swissprot:UCP1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:UCP1_HUMAN
neXtProt	NX_P25874	http://www.nextprot.org/db/entry/NX_P25874
octanol	swissprot:UCP1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:UCP1_HUMAN
pepcoil	swissprot:UCP1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:UCP1_HUMAN
pepdigest	swissprot:UCP1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:UCP1_HUMAN
pepinfo	swissprot:UCP1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:UCP1_HUMAN
pepnet	swissprot:UCP1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:UCP1_HUMAN
pepstats	swissprot:UCP1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:UCP1_HUMAN
pepwheel	swissprot:UCP1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:UCP1_HUMAN
pepwindow	swissprot:UCP1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:UCP1_HUMAN
sigcleave	swissprot:UCP1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:UCP1_HUMAN
## Database	ID	URL or Descriptions
# AltName	RBP1_HUMAN	76 kDa Ral-interacting protein
# AltName	RBP1_HUMAN	Dinitrophenyl S-glutathione ATPase
# AltName	RBP1_HUMAN	Ral-interacting protein 1
# BioGrid	116131	82
# ChiTaRS	RALBP1	human
# DrugBank	DB00398	Sorafenib
# DrugBank	DB00541	Vincristine
# DrugBank	DB00564	Carbamazepine
# DrugBank	DB00997	Doxorubicin
# Ensembl	ENST00000019317	ENSP00000019317; ENSG00000017797
# Ensembl	ENST00000383432	ENSP00000372924; ENSG00000017797
# ExpressionAtlas	Q15311	baseline and differential
# FUNCTION	RBP1_HUMAN	Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin. {ECO 0000269|PubMed 11437348, ECO 0000269|PubMed 12775724, ECO 0000269|PubMed 7673236}. 
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_function	GO:0005096	GTPase activator activity; IDA:UniProtKB.
# GO_function	GO:0016887	ATPase activity; IDA:UniProtKB.
# GO_function	GO:0017160	Ral GTPase binding; IPI:UniProtKB.
# GO_function	GO:0022857	transmembrane transporter activity; IDA:ParkinsonsUK-UCL.
# GO_function	GO:0043492	ATPase activity, coupled to movement of substances; TAS:UniProtKB.
# GO_function	GO:0048365	Rac GTPase binding; IPI:UniProtKB.
# GO_process	GO:0006810	transport; IDA:UniProtKB.
# GO_process	GO:0006897	endocytosis; IBA:GO_Central.
# GO_process	GO:0006935	chemotaxis; TAS:ProtInc.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0007264	small GTPase mediated signal transduction; IPI:UniProtKB.
# GO_process	GO:0043087	regulation of GTPase activity; IDA:UniProtKB.
# GO_process	GO:0043547	positive regulation of GTPase activity; IDA:UniProtKB.
# GO_process	GO:0051056	regulation of small GTPase mediated signal transduction; TAS:Reactome.
# GO_process	GO:0055085	transmembrane transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005829	cytosol
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0030234	enzyme regulator activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0040011	locomotion
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.10.555.10	-; 1.
# Genevisible	Q15311	HS
# HGNC	HGNC:9841	RALBP1
# INTERACTION	RBP1_HUMAN	Q9H6F0 -; NbExp=3; IntAct=EBI-749285, EBI-10307481; Q9Y2J4-4 AMOTL2; NbExp=3; IntAct=EBI-749285, EBI-10187270; Q8TAB5 C1orf216; NbExp=5; IntAct=EBI-749285, EBI-747505; Q16204 CCDC6; NbExp=4; IntAct=EBI-749285, EBI-1045350; P78556 CCL20; NbExp=2; IntAct=EBI-749285, EBI-3913209; Q86XR8 CEP57; NbExp=4; IntAct=EBI-749285, EBI-308614; Q13227 GPS2; NbExp=7; IntAct=EBI-749285, EBI-713355; Q63ZY3 KANK2; NbExp=4; IntAct=EBI-749285, EBI-2556193; O60437 PPL; NbExp=3; IntAct=EBI-749285, EBI-368321; Q969G3 SMARCE1; NbExp=5; IntAct=EBI-749285, EBI-455078; Q86VP1 TAX1BP1; NbExp=3; IntAct=EBI-749285, EBI-529518; Q05BL0 TBRG1; NbExp=3; IntAct=EBI-749285, EBI-10223693; G5E9B5 TFPT; NbExp=5; IntAct=EBI-749285, EBI-10178002; Q15025 TNIP1; NbExp=3; IntAct=EBI-749285, EBI-357849; Q96C28 ZNF707; NbExp=3; IntAct=EBI-749285, EBI-748111; 
# IntAct	Q15311	46
# InterPro	IPR000198	RhoGAP_dom
# InterPro	IPR008936	Rho_GTPase_activation_prot
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Pathway	ko05200	Pathways in cancer
# KEGG_Pathway	ko05212	Pancreatic cancer
# MIM	605801	gene
# Organism	RBP1_HUMAN	Homo sapiens (Human)
# PDB	2KWH	NMR; -; A=393-446
# PDB	2KWI	NMR; -; B=393-446
# PDB	2MBG	NMR; -; A=184-446
# PIR	F59435	F59435
# PROSITE	PS50238	RHOGAP
# Pfam	PF00620	RhoGAP
# Proteomes	UP000005640	Chromosome 18
# Reactome	R-HSA-194840	Rho GTPase cycle
# RecName	RBP1_HUMAN	RalA-binding protein 1
# RefSeq	NP_006779	NM_006788.3
# SIMILARITY	Contains 1 Rho-GAP domain. {ECO:0000255|PROSITE- ProRule	PRU00172}.
# SMART	SM00324	RhoGAP
# SUBCELLULAR LOCATION	RBP1_HUMAN	Membrane {ECO 0000269|PubMed 11437348}; Peripheral membrane protein {ECO 0000269|PubMed 11437348}. 
# SUBUNIT	RBP1_HUMAN	Interacts with the GTP-bound form of RALA, RALB, CDC42 and RAC1. Interacts with REPS1 and REPS2 and this does not affect the Ral-binding activity. Interacts with DAB2IP. Interacts with catalytically active CCNB1 and CDK1 during mitosis. Interacts with EPN1, NUMB and TFAP2A during interphase and mitosis. {ECO 0000269|PubMed 12775724, ECO 0000269|PubMed 15310755, ECO 0000269|PubMed 20696399, ECO 0000269|PubMed 7673236, ECO 0000269|PubMed 9422736}. 
# SUPFAM	SSF48350	SSF48350
# TCDB	9.A.1.1	the non abc multidrug exporter (n-mde) family
# TISSUE SPECIFICITY	Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes. {ECO:0000269|PubMed	11437348}. 
# UCSC	uc002kob	human
# eggNOG	ENOG410XRJ9	LUCA
# eggNOG	KOG4370	Eukaryota
BLAST	swissprot:RBP1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:RBP1_HUMAN
BioCyc	ZFISH:ENSG00000017797-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000017797-MONOMER
COXPRESdb	10928	http://coxpresdb.jp/data/gene/10928.shtml
CleanEx	HS_RALBP1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_RALBP1
DOI	10.1006/abbi.2001.2395	http://dx.doi.org/10.1006/abbi.2001.2395
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.str.2010.05.013	http://dx.doi.org/10.1016/j.str.2010.05.013
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/bi992964c	http://dx.doi.org/10.1021/bi992964c
DOI	10.1021/pr0704130	http://dx.doi.org/10.1021/pr0704130
DOI	10.1021/pr0705441	http://dx.doi.org/10.1021/pr0705441
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/jbc.270.38.22473	http://dx.doi.org/10.1074/jbc.270.38.22473
DOI	10.1074/jbc.273.2.814	http://dx.doi.org/10.1074/jbc.273.2.814
DOI	10.1074/jbc.M302191200	http://dx.doi.org/10.1074/jbc.M302191200
DOI	10.1074/jbc.M407617200	http://dx.doi.org/10.1074/jbc.M407617200
DOI	10.1074/mcp.M800588-MCP200	http://dx.doi.org/10.1074/mcp.M800588-MCP200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DrugBank	DB00398	http://www.drugbank.ca/drugs/DB00398
DrugBank	DB00541	http://www.drugbank.ca/drugs/DB00541
DrugBank	DB00564	http://www.drugbank.ca/drugs/DB00564
DrugBank	DB00997	http://www.drugbank.ca/drugs/DB00997
EMBL	BC013126	http://www.ebi.ac.uk/ena/data/view/BC013126
EMBL	CH471113	http://www.ebi.ac.uk/ena/data/view/CH471113
EMBL	CH471113	http://www.ebi.ac.uk/ena/data/view/CH471113
EMBL	CH471113	http://www.ebi.ac.uk/ena/data/view/CH471113
EMBL	CH471113	http://www.ebi.ac.uk/ena/data/view/CH471113
EMBL	L42542	http://www.ebi.ac.uk/ena/data/view/L42542
Ensembl	ENST00000019317	http://www.ensembl.org/id/ENST00000019317
Ensembl	ENST00000383432	http://www.ensembl.org/id/ENST00000383432
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0005096	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005096
GO_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GO_function	GO:0017160	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017160
GO_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GO_function	GO:0043492	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043492
GO_function	GO:0048365	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048365
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006897	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006897
GO_process	GO:0006935	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006935
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007264	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007264
GO_process	GO:0043087	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043087
GO_process	GO:0043547	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043547
GO_process	GO:0051056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051056
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0030234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0040011	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.10.555.10	http://www.cathdb.info/version/latest/superfamily/1.10.555.10
GeneCards	RALBP1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=RALBP1
GeneID	10928	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10928
GeneTree	ENSGT00840000129752	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00840000129752
HGNC	HGNC:9841	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:9841
HOGENOM	HOG000007929	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007929&db=HOGENOM6
HOVERGEN	HBG044496	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG044496&db=HOVERGEN
HPA	CAB046010	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB046010
HPA	HPA046651	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA046651
InParanoid	Q15311	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q15311
IntAct	Q15311	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q15311*
InterPro	IPR000198	http://www.ebi.ac.uk/interpro/entry/IPR000198
InterPro	IPR008936	http://www.ebi.ac.uk/interpro/entry/IPR008936
Jabion	10928	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10928
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Gene	hsa:10928	http://www.genome.jp/dbget-bin/www_bget?hsa:10928
KEGG_Orthology	KO:K08773	http://www.genome.jp/dbget-bin/www_bget?KO:K08773
KEGG_Pathway	ko05200	http://www.genome.jp/kegg-bin/show_pathway?ko05200
KEGG_Pathway	ko05212	http://www.genome.jp/kegg-bin/show_pathway?ko05212
MIM	605801	http://www.ncbi.nlm.nih.gov/omim/605801
MINT	MINT-140436	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-140436
OMA	YDELMEW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YDELMEW
OrthoDB	EOG091G01CT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01CT
PDB	2KWH	http://www.ebi.ac.uk/pdbe-srv/view/entry/2KWH
PDB	2KWI	http://www.ebi.ac.uk/pdbe-srv/view/entry/2KWI
PDB	2MBG	http://www.ebi.ac.uk/pdbe-srv/view/entry/2MBG
PDBsum	2KWH	http://www.ebi.ac.uk/pdbsum/2KWH
PDBsum	2KWI	http://www.ebi.ac.uk/pdbsum/2KWI
PDBsum	2MBG	http://www.ebi.ac.uk/pdbsum/2MBG
PROSITE	PS50238	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50238
PSORT	swissprot:RBP1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:RBP1_HUMAN
PSORT-B	swissprot:RBP1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:RBP1_HUMAN
PSORT2	swissprot:RBP1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:RBP1_HUMAN
Pfam	PF00620	http://pfam.xfam.org/family/PF00620
PharmGKB	PA34199	http://www.pharmgkb.org/do/serve?objId=PA34199&objCls=Gene
Phobius	swissprot:RBP1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:RBP1_HUMAN
PhylomeDB	Q15311	http://phylomedb.org/?seqid=Q15311
ProteinModelPortal	Q15311	http://www.proteinmodelportal.org/query/uniprot/Q15311
PubMed	10924126	http://www.ncbi.nlm.nih.gov/pubmed/10924126
PubMed	11437348	http://www.ncbi.nlm.nih.gov/pubmed/11437348
PubMed	12775724	http://www.ncbi.nlm.nih.gov/pubmed/12775724
PubMed	15310755	http://www.ncbi.nlm.nih.gov/pubmed/15310755
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	18088087	http://www.ncbi.nlm.nih.gov/pubmed/18088087
PubMed	18220336	http://www.ncbi.nlm.nih.gov/pubmed/18220336
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19369195	http://www.ncbi.nlm.nih.gov/pubmed/19369195
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20696399	http://www.ncbi.nlm.nih.gov/pubmed/20696399
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	7673236	http://www.ncbi.nlm.nih.gov/pubmed/7673236
PubMed	9422736	http://www.ncbi.nlm.nih.gov/pubmed/9422736
Reactome	R-HSA-194840	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-194840
RefSeq	NP_006779	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006779
SMART	SM00324	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00324
SMR	Q15311	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q15311
STRING	9606.ENSP00000019317	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000019317&targetmode=cogs
SUPFAM	SSF48350	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48350
TCDB	9.A.1.1	http://www.tcdb.org/search/result.php?tc=9.A.1.1
UCSC	uc002kob	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002kob&org=rat
UniGene	Hs.528993	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.528993
UniProtKB	RBP1_HUMAN	http://www.uniprot.org/uniprot/RBP1_HUMAN
UniProtKB-AC	Q15311	http://www.uniprot.org/uniprot/Q15311
charge	swissprot:RBP1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:RBP1_HUMAN
eggNOG	ENOG410XRJ9	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRJ9
eggNOG	KOG4370	http://eggnogapi.embl.de/nog_data/html/tree/KOG4370
epestfind	swissprot:RBP1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:RBP1_HUMAN
garnier	swissprot:RBP1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:RBP1_HUMAN
helixturnhelix	swissprot:RBP1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:RBP1_HUMAN
hmoment	swissprot:RBP1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:RBP1_HUMAN
iep	swissprot:RBP1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:RBP1_HUMAN
inforesidue	swissprot:RBP1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:RBP1_HUMAN
neXtProt	NX_Q15311	http://www.nextprot.org/db/entry/NX_Q15311
octanol	swissprot:RBP1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:RBP1_HUMAN
pepcoil	swissprot:RBP1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:RBP1_HUMAN
pepdigest	swissprot:RBP1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:RBP1_HUMAN
pepinfo	swissprot:RBP1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:RBP1_HUMAN
pepnet	swissprot:RBP1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:RBP1_HUMAN
pepstats	swissprot:RBP1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:RBP1_HUMAN
pepwheel	swissprot:RBP1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:RBP1_HUMAN
pepwindow	swissprot:RBP1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:RBP1_HUMAN
sigcleave	swissprot:RBP1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:RBP1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S36A1_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q7Z2H8-1; Sequence=Displayed; Name=2; IsoId=Q7Z2H8-3; Sequence=VSP_044392; Name=3; IsoId=Q7Z2H8-4; Sequence=VSP_044390, VSP_044391; 
# AltName	S36A1_HUMAN	Solute carrier family 36 member 1
# BioGrid	128503	3
# CCDS	CCDS4316	-. [Q7Z2H8-1]
# CCDS	CCDS78073	-. [Q7Z2H8-4]
# CCDS	CCDS83035	-. [Q7Z2H8-3]
# ChiTaRS	SLC36A1	human
# DrugBank	DB00145	Glycine
# DrugBank	DB00160	L-Alanine
# DrugBank	DB00659	Acamprosate
# DrugBank	DB01080	Vigabatrin
# DrugBank	DB08835	Spaglumic Acid
# DrugBank	DB08847	Hydroxyproline
# Ensembl	ENST00000243389	ENSP00000243389; ENSG00000123643. [Q7Z2H8-1]
# Ensembl	ENST00000429484	ENSP00000395640; ENSG00000123643. [Q7Z2H8-4]
# Ensembl	ENST00000520701	ENSP00000428140; ENSG00000123643. [Q7Z2H8-1]
# Ensembl	ENST00000616007	ENSP00000480948; ENSG00000123643. [Q7Z2H8-3]
# ExpressionAtlas	Q7Z2H8	baseline and differential
# FUNCTION	S36A1_HUMAN	Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid (By similarity). {ECO 0000250, ECO 0000269|PubMed 12809675}. 
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005783	endoplasmic reticulum; IDA:LIFEdb.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015078	hydrogen ion transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015180	L-alanine transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015187	glycine transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015193	L-proline transmembrane transporter activity; IBA:GO_Central.
# GO_function	S36A1_HUMAN	GO 0005280 hydrogen amino acid symporter activity; IBA GO_Central.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006865	amino acid transport; TAS:Reactome.
# GO_process	GO:0015816	glycine transport; IBA:GO_Central.
# GO_process	GO:0015824	proline transport; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q7Z2H8	HS
# HGNC	HGNC:18761	SLC36A1
# IntAct	Q7Z2H8	7
# InterPro	IPR013057	AA_transpt_TM
# KEGG_Brite	ko02001	Solute carrier family
# MIM	606561	gene
# Organism	S36A1_HUMAN	Homo sapiens (Human)
# Pfam	PF01490	Aa_trans
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-352230	Amino acid transport across the plasma membrane
# Reactome	R-HSA-428559	Proton-coupled neutral amino acid transporters
# RecName	S36A1_HUMAN	Proton-coupled amino acid transporter 1
# RefSeq	NP_001295079	NM_001308150.1. [Q7Z2H8-3]
# RefSeq	NP_001295080	NM_001308151.1. [Q7Z2H8-4]
# RefSeq	NP_510968	NM_078483.3. [Q7Z2H8-1]
# RefSeq	XP_005268443	XM_005268386.1. [Q7Z2H8-1]
# RefSeq	XP_011535883	XM_011537581.1. [Q7Z2H8-1]
# RefSeq	XP_011535885	XM_011537583.2. [Q7Z2H8-1]
# RefSeq	XP_011535886	XM_011537584.2. [Q7Z2H8-1]
# RefSeq	XP_011535887	XM_011537585.1. [Q7Z2H8-1]
# RefSeq	XP_011535888	XM_011537586.2. [Q7Z2H8-1]
# RefSeq	XP_011535889	XM_011537587.2. [Q7Z2H8-1]
# RefSeq	XP_011535890	XM_011537588.2. [Q7Z2H8-1]
# RefSeq	XP_011535891	XM_011537589.2. [Q7Z2H8-1]
# RefSeq	XP_011535892	XM_011537590.1. [Q7Z2H8-1]
# RefSeq	XP_011535893	XM_011537591.1. [Q7Z2H8-1]
# RefSeq	XP_011535894	XM_011537592.2. [Q7Z2H8-1]
# RefSeq	XP_016864705	XM_017009216.1. [Q7Z2H8-1]
# RefSeq	XP_016864709	XM_017009220.1. [Q7Z2H8-4]
# SEQUENCE CAUTION	Sequence=BAB71435.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the amino acid/polyamine transporter 2 family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S36A1_HUMAN	Cell membrane {ECO 0000250|UniProtKB Q924A5}; Multi-pass membrane protein {ECO 0000255}. Lysosome membrane {ECO 0000269|PubMed 17897319}; Multi-pass membrane protein {ECO 0000269|PubMed 17897319}. Note=In neurons, colocalizes with the exocyst complex in the axonal processes. {ECO 0000250|UniProtKB Q924A5}. 
# TCDB	2.A.18.8	the amino acid/auxin permease (aaap) family
# TopDownProteomics	Q7Z2H8-1	-. [Q7Z2H8-1]
# UCSC	uc003luc	human. [Q7Z2H8-1]
# eggNOG	COG0814	LUCA
# eggNOG	KOG1304	Eukaryota
BLAST	swissprot:S36A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S36A1_HUMAN
COXPRESdb	206358	http://coxpresdb.jp/data/gene/206358.shtml
CleanEx	HS_SLC36A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC36A1
DOI	10.1007/s00335-003-2319-3	http://dx.doi.org/10.1007/s00335-003-2319-3
DOI	10.1016/S0888-7543(03)00099-5	http://dx.doi.org/10.1016/S0888-7543(03)00099-5
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M109.023713	http://dx.doi.org/10.1074/jbc.M109.023713
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1600-0854.2007.00643.x	http://dx.doi.org/10.1111/j.1600-0854.2007.00643.x
DOI	10.1113/jphysiol.2002.026500	http://dx.doi.org/10.1113/jphysiol.2002.026500
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DrugBank	DB00145	http://www.drugbank.ca/drugs/DB00145
DrugBank	DB00160	http://www.drugbank.ca/drugs/DB00160
DrugBank	DB00659	http://www.drugbank.ca/drugs/DB00659
DrugBank	DB01080	http://www.drugbank.ca/drugs/DB01080
DrugBank	DB08835	http://www.drugbank.ca/drugs/DB08835
DrugBank	DB08847	http://www.drugbank.ca/drugs/DB08847
EMBL	AC034205	http://www.ebi.ac.uk/ena/data/view/AC034205
EMBL	AF516142	http://www.ebi.ac.uk/ena/data/view/AF516142
EMBL	AK057340	http://www.ebi.ac.uk/ena/data/view/AK057340
EMBL	AY162213	http://www.ebi.ac.uk/ena/data/view/AY162213
EMBL	AY227111	http://www.ebi.ac.uk/ena/data/view/AY227111
EMBL	AY227112	http://www.ebi.ac.uk/ena/data/view/AY227112
EMBL	AY227113	http://www.ebi.ac.uk/ena/data/view/AY227113
EMBL	BC136437	http://www.ebi.ac.uk/ena/data/view/BC136437
EMBL	BC136438	http://www.ebi.ac.uk/ena/data/view/BC136438
EMBL	BK001052	http://www.ebi.ac.uk/ena/data/view/BK001052
EMBL	BX537963	http://www.ebi.ac.uk/ena/data/view/BX537963
Ensembl	ENST00000243389	http://www.ensembl.org/id/ENST00000243389
Ensembl	ENST00000429484	http://www.ensembl.org/id/ENST00000429484
Ensembl	ENST00000520701	http://www.ensembl.org/id/ENST00000520701
Ensembl	ENST00000616007	http://www.ensembl.org/id/ENST00000616007
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005280	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005280
GO_function	GO:0015078	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015078
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_function	GO:0015180	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015180
GO_function	GO:0015187	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015187
GO_function	GO:0015193	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015193
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GO_process	GO:0015816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015816
GO_process	GO:0015824	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015824
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC36A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC36A1
GeneID	206358	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=206358
GeneTree	ENSGT00390000011245	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000011245
HGNC	HGNC:18761	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18761
HOGENOM	HOG000171648	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000171648&db=HOGENOM6
HOVERGEN	HBG057183	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG057183&db=HOVERGEN
HPA	HPA035937	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035937
InParanoid	Q7Z2H8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q7Z2H8
IntAct	Q7Z2H8	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q7Z2H8*
InterPro	IPR013057	http://www.ebi.ac.uk/interpro/entry/IPR013057
Jabion	206358	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=206358
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:206358	http://www.genome.jp/dbget-bin/www_bget?hsa:206358
KEGG_Orthology	KO:K14209	http://www.genome.jp/dbget-bin/www_bget?KO:K14209
MIM	606561	http://www.ncbi.nlm.nih.gov/omim/606561
MINT	MINT-4722054	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4722054
OMA	SHWGRRI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SHWGRRI
OrthoDB	EOG091G079T	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G079T
PSORT	swissprot:S36A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S36A1_HUMAN
PSORT-B	swissprot:S36A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S36A1_HUMAN
PSORT2	swissprot:S36A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S36A1_HUMAN
Pfam	PF01490	http://pfam.xfam.org/family/PF01490
PharmGKB	PA134870308	http://www.pharmgkb.org/do/serve?objId=PA134870308&objCls=Gene
Phobius	swissprot:S36A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S36A1_HUMAN
PhylomeDB	Q7Z2H8	http://phylomedb.org/?seqid=Q7Z2H8
ProteinModelPortal	Q7Z2H8	http://www.proteinmodelportal.org/query/uniprot/Q7Z2H8
PubMed	12527723	http://www.ncbi.nlm.nih.gov/pubmed/12527723
PubMed	12809675	http://www.ncbi.nlm.nih.gov/pubmed/12809675
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15058382	http://www.ncbi.nlm.nih.gov/pubmed/15058382
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17897319	http://www.ncbi.nlm.nih.gov/pubmed/17897319
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	19549785	http://www.ncbi.nlm.nih.gov/pubmed/19549785
Reactome	R-HSA-352230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-352230
Reactome	R-HSA-428559	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428559
RefSeq	NP_001295079	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001295079
RefSeq	NP_001295080	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001295080
RefSeq	NP_510968	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_510968
RefSeq	XP_005268443	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005268443
RefSeq	XP_011535883	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011535883
RefSeq	XP_011535885	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011535885
RefSeq	XP_011535886	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011535886
RefSeq	XP_011535887	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011535887
RefSeq	XP_011535888	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011535888
RefSeq	XP_011535889	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011535889
RefSeq	XP_011535890	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011535890
RefSeq	XP_011535891	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011535891
RefSeq	XP_011535892	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011535892
RefSeq	XP_011535893	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011535893
RefSeq	XP_011535894	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011535894
RefSeq	XP_016864705	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016864705
RefSeq	XP_016864709	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016864709
STRING	9606.ENSP00000243389	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000243389&targetmode=cogs
TCDB	2.A.18.8	http://www.tcdb.org/search/result.php?tc=2.A.18.8
UCSC	uc003luc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003luc&org=rat
UniGene	Hs.269004	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.269004
UniProtKB	S36A1_HUMAN	http://www.uniprot.org/uniprot/S36A1_HUMAN
UniProtKB-AC	Q7Z2H8	http://www.uniprot.org/uniprot/Q7Z2H8
charge	swissprot:S36A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S36A1_HUMAN
eggNOG	COG0814	http://eggnogapi.embl.de/nog_data/html/tree/COG0814
eggNOG	KOG1304	http://eggnogapi.embl.de/nog_data/html/tree/KOG1304
epestfind	swissprot:S36A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S36A1_HUMAN
garnier	swissprot:S36A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S36A1_HUMAN
helixturnhelix	swissprot:S36A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S36A1_HUMAN
hmoment	swissprot:S36A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S36A1_HUMAN
iep	swissprot:S36A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S36A1_HUMAN
inforesidue	swissprot:S36A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S36A1_HUMAN
neXtProt	NX_Q7Z2H8	http://www.nextprot.org/db/entry/NX_Q7Z2H8
octanol	swissprot:S36A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S36A1_HUMAN
pepcoil	swissprot:S36A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S36A1_HUMAN
pepdigest	swissprot:S36A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S36A1_HUMAN
pepinfo	swissprot:S36A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S36A1_HUMAN
pepnet	swissprot:S36A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S36A1_HUMAN
pepstats	swissprot:S36A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S36A1_HUMAN
pepwheel	swissprot:S36A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S36A1_HUMAN
pepwindow	swissprot:S36A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S36A1_HUMAN
sigcleave	swissprot:S36A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S36A1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	FXYD6_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H0Q3-1; Sequence=Displayed; Name=2; IsoId=Q9H0Q3-2; Sequence=VSP_045996; Note=No experimental confirmation available.; 
# AltName	FXYD6_HUMAN	Phosphohippolin
# BioGrid	119799	16
# CCDS	CCDS8387	-. [Q9H0Q3-1]
# DISEASE	FXYD6_HUMAN	Schizophrenia 2 (SCZD2) [MIM 603342]  A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. {ECO 0000269|PubMed 17357072}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# Ensembl	ENST00000260282	ENSP00000260282; ENSG00000137726. [Q9H0Q3-1]
# Ensembl	ENST00000524656	ENSP00000431427; ENSG00000137726. [Q9H0Q3-1]
# Ensembl	ENST00000526014	ENSP00000433312; ENSG00000137726. [Q9H0Q3-1]
# Ensembl	ENST00000527717	ENSP00000431446; ENSG00000137726. [Q9H0Q3-1]
# Ensembl	ENST00000530956	ENSP00000463158; ENSG00000137726. [Q9H0Q3-1]
# Ensembl	ENST00000539526	ENSP00000442756; ENSG00000137726. [Q9H0Q3-1]
# ExpressionAtlas	Q9H0Q3	baseline and differential
# GO_component	GO:0005886	plasma membrane; IDA:LIFEdb.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005216	ion channel activity; IEA:InterPro.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9H0Q3	HS
# HGNC	HGNC:4030	FXYD6
# INTERACTION	FXYD6_HUMAN	Q96BA8 CREB3L1; NbExp=3; IntAct=EBI-713304, EBI-6942903; 
# IntAct	Q9H0Q3	19
# InterPro	IPR000272	Ion-transport_regulator_FXYD
# KEGG_Brite	ko02000	Transporters
# MIM	181500	phenotype
# MIM	603342	phenotype
# MIM	606683	gene
# Organism	FXYD6_HUMAN	Homo sapiens (Human)
# Orphanet	3140	Schizophrenia
# PROSITE	PS01310	FXYD
# Pfam	PF02038	ATP1G1_PLM_MAT8
# ProDom	PD005989	PD005989
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-5578775	Ion homeostasis
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	FXYD6_HUMAN	FXYD domain-containing ion transport regulator 6
# RefSeq	NP_001158303	NM_001164831.2. [Q9H0Q3-1]
# RefSeq	NP_001158304	NM_001164832.2. [Q9H0Q3-1]
# RefSeq	NP_001158308	NM_001164836.2. [Q9H0Q3-1]
# RefSeq	NP_001158309	NM_001164837.2. [Q9H0Q3-1]
# RefSeq	NP_071286	NM_022003.3. [Q9H0Q3-1]
# SEQUENCE CAUTION	Sequence=AAQ89335.1; Type=Frameshift; Positions=93; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the FXYD family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	FXYD6_HUMAN	Membrane {ECO 0000305}; Single-pass type I membrane protein {ECO 0000305}. 
# TCDB	1.A.27.1	the phospholemman (plm) family
# UCSC	uc001pro	human. [Q9H0Q3-1]
# eggNOG	ENOG410IZ88	Eukaryota
# eggNOG	ENOG410YUN8	LUCA
BLAST	swissprot:FXYD6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:FXYD6_HUMAN
BioCyc	ZFISH:ENSG00000137726-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000137726-MONOMER
COXPRESdb	53826	http://coxpresdb.jp/data/gene/53826.shtml
CleanEx	HS_FXYD6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_FXYD6
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1038/nbt971	http://dx.doi.org/10.1038/nbt971
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1086/513475	http://dx.doi.org/10.1086/513475
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1101/gr.GR1547R	http://dx.doi.org/10.1101/gr.GR1547R
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AK289629	http://www.ebi.ac.uk/ena/data/view/AK289629
EMBL	AK290757	http://www.ebi.ac.uk/ena/data/view/AK290757
EMBL	AL136699	http://www.ebi.ac.uk/ena/data/view/AL136699
EMBL	AL832811	http://www.ebi.ac.uk/ena/data/view/AL832811
EMBL	AP000757	http://www.ebi.ac.uk/ena/data/view/AP000757
EMBL	AY358976	http://www.ebi.ac.uk/ena/data/view/AY358976
EMBL	BC018652	http://www.ebi.ac.uk/ena/data/view/BC018652
EMBL	BC093040	http://www.ebi.ac.uk/ena/data/view/BC093040
EMBL	BT006717	http://www.ebi.ac.uk/ena/data/view/BT006717
EMBL	CH471065	http://www.ebi.ac.uk/ena/data/view/CH471065
EMBL	CN310658	http://www.ebi.ac.uk/ena/data/view/CN310658
EMBL	CR533457	http://www.ebi.ac.uk/ena/data/view/CR533457
Ensembl	ENST00000260282	http://www.ensembl.org/id/ENST00000260282
Ensembl	ENST00000524656	http://www.ensembl.org/id/ENST00000524656
Ensembl	ENST00000526014	http://www.ensembl.org/id/ENST00000526014
Ensembl	ENST00000527717	http://www.ensembl.org/id/ENST00000527717
Ensembl	ENST00000530956	http://www.ensembl.org/id/ENST00000530956
Ensembl	ENST00000539526	http://www.ensembl.org/id/ENST00000539526
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005216	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005216
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	FXYD6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=FXYD6
GeneID	53826	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=53826
GeneTree	ENSGT00530000063932	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063932
HGNC	HGNC:4030	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4030
HOGENOM	HOG000234467	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234467&db=HOGENOM6
HOVERGEN	HBG008212	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG008212&db=HOVERGEN
HPA	HPA041334	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA041334
InParanoid	Q9H0Q3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9H0Q3
IntAct	Q9H0Q3	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9H0Q3*
InterPro	IPR000272	http://www.ebi.ac.uk/interpro/entry/IPR000272
Jabion	53826	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=53826
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:53826	http://www.genome.jp/dbget-bin/www_bget?hsa:53826
KEGG_Orthology	KO:K13363	http://www.genome.jp/dbget-bin/www_bget?KO:K13363
MIM	181500	http://www.ncbi.nlm.nih.gov/omim/181500
MIM	603342	http://www.ncbi.nlm.nih.gov/omim/603342
MIM	606683	http://www.ncbi.nlm.nih.gov/omim/606683
MINT	MINT-1372177	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1372177
Orphanet	3140	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=3140
PROSITE	PS01310	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01310
PSORT	swissprot:FXYD6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:FXYD6_HUMAN
PSORT-B	swissprot:FXYD6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:FXYD6_HUMAN
PSORT2	swissprot:FXYD6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:FXYD6_HUMAN
Pfam	PF02038	http://pfam.xfam.org/family/PF02038
PharmGKB	PA28446	http://www.pharmgkb.org/do/serve?objId=PA28446&objCls=Gene
Phobius	swissprot:FXYD6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:FXYD6_HUMAN
PhylomeDB	Q9H0Q3	http://phylomedb.org/?seqid=Q9H0Q3
ProteinModelPortal	Q9H0Q3	http://www.proteinmodelportal.org/query/uniprot/Q9H0Q3
PubMed	11230166	http://www.ncbi.nlm.nih.gov/pubmed/11230166
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15146197	http://www.ncbi.nlm.nih.gov/pubmed/15146197
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	17357072	http://www.ncbi.nlm.nih.gov/pubmed/17357072
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_001158303	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001158303
RefSeq	NP_001158304	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001158304
RefSeq	NP_001158308	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001158308
RefSeq	NP_001158309	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001158309
RefSeq	NP_071286	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_071286
SMR	Q9H0Q3	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9H0Q3
STRING	9606.ENSP00000260282	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000260282&targetmode=cogs
TCDB	1.A.27.1	http://www.tcdb.org/search/result.php?tc=1.A.27.1
UCSC	uc001pro	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001pro&org=rat
UniGene	Hs.744850	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.744850
UniProtKB	FXYD6_HUMAN	http://www.uniprot.org/uniprot/FXYD6_HUMAN
UniProtKB-AC	Q9H0Q3	http://www.uniprot.org/uniprot/Q9H0Q3
charge	swissprot:FXYD6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:FXYD6_HUMAN
eggNOG	ENOG410IZ88	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IZ88
eggNOG	ENOG410YUN8	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YUN8
epestfind	swissprot:FXYD6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:FXYD6_HUMAN
garnier	swissprot:FXYD6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:FXYD6_HUMAN
helixturnhelix	swissprot:FXYD6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:FXYD6_HUMAN
hmoment	swissprot:FXYD6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:FXYD6_HUMAN
iep	swissprot:FXYD6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:FXYD6_HUMAN
inforesidue	swissprot:FXYD6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:FXYD6_HUMAN
neXtProt	NX_Q9H0Q3	http://www.nextprot.org/db/entry/NX_Q9H0Q3
octanol	swissprot:FXYD6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:FXYD6_HUMAN
pepcoil	swissprot:FXYD6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:FXYD6_HUMAN
pepdigest	swissprot:FXYD6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:FXYD6_HUMAN
pepinfo	swissprot:FXYD6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:FXYD6_HUMAN
pepnet	swissprot:FXYD6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:FXYD6_HUMAN
pepstats	swissprot:FXYD6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:FXYD6_HUMAN
pepwheel	swissprot:FXYD6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:FXYD6_HUMAN
pepwindow	swissprot:FXYD6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:FXYD6_HUMAN
sigcleave	swissprot:FXYD6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:FXYD6_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ABCB9_HUMAN	Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=12A, c1-l; IsoId=Q9NP78-1; Sequence=Displayed; Name=2; Synonyms=c1-s; IsoId=Q9NP78-2; Sequence=VSP_000027; Name=3; IsoId=Q9NP78-3; Sequence=VSP_000029, VSP_000030; Note=No experimental confirmation available.; Name=4; Synonyms=12B; IsoId=Q9NP78-5; Sequence=VSP_041884, VSP_041886; Name=5; Synonyms=12C; IsoId=Q9NP78-6; Sequence=VSP_041885; Name=6; IsoId=Q9NP78-7; Sequence=VSP_044884; Note=No experimental confirmation available.; 
# AltName	ABCB9_HUMAN	ATP-binding cassette transporter 9
# AltName	ABCB9_HUMAN	TAP-like protein
# BIOPHYSICOCHEMICAL PROPERTIES	ABCB9_HUMAN	Kinetic parameters  KM=6.8 uM for peptide RRYQNSTCL {ECO 0000269|PubMed 15863492}; pH dependence  Optimum pH is 7.0. {ECO 0000269|PubMed 15863492}; Temperature dependence  Optimum temperature is 37 degrees Celsius. {ECO 0000269|PubMed 15863492}; 
# BRENDA	3.6.3.43	2681
# BioGrid	117021	10
# CAUTION	Has also been detected in the endoplasmic reticulum but appears to be a lysosomal protein in vivo. {ECO:0000305|PubMed	11011155}. 
# CCDS	CCDS58286	-. [Q9NP78-7]
# CCDS	CCDS58287	-. [Q9NP78-6]
# CCDS	CCDS58288	-. [Q9NP78-5]
# CCDS	CCDS9241	-. [Q9NP78-1]
# DOMAIN	ABCB9_HUMAN	The N-terminal region comprising the first four transmembrane domains is required for lysosomal localization but not for homodimerization or peptide transport. {ECO 0000269|PubMed 15577206, ECO 0000269|PubMed 18175933, ECO 0000269|PubMed 20377823}. 
# Ensembl	ENST00000280560	ENSP00000280560; ENSG00000150967. [Q9NP78-1]
# Ensembl	ENST00000344275	ENSP00000456813; ENSG00000150967. [Q9NP78-6]
# Ensembl	ENST00000346530	ENSP00000280559; ENSG00000150967. [Q9NP78-2]
# Ensembl	ENST00000392439	ENSP00000376234; ENSG00000150967. [Q9NP78-1]
# Ensembl	ENST00000442833	ENSP00000456375; ENSG00000150967. [Q9NP78-5]
# Ensembl	ENST00000540285	ENSP00000441734; ENSG00000150967. [Q9NP78-7]
# Ensembl	ENST00000542678	ENSP00000440288; ENSG00000150967. [Q9NP78-1]
# ExpressionAtlas	Q9NP78	baseline and differential
# FUNCTION	ABCB9_HUMAN	ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored. {ECO 0000269|PubMed 15863492, ECO 0000269|PubMed 17977821, ECO 0000269|PubMed 18434309}. 
# GO_component	GO:0005764	lysosome; IDA:UniProtKB.
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IDA:UniProtKB.
# GO_component	GO:0030176	integral component of endoplasmic reticulum membrane; IDA:UniProtKB.
# GO_function	GO:0005524	ATP binding; IDA:UniProtKB.
# GO_function	GO:0015421	oligopeptide-transporting ATPase activity; TAS:Reactome.
# GO_function	GO:0015440	peptide-transporting ATPase activity; IDA:UniProtKB.
# GO_function	GO:0022891	substrate-specific transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0042803	protein homodimerization activity; IDA:UniProtKB.
# GO_process	GO:0002481	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; IBA:GO_Central.
# GO_process	GO:0002485	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; IBA:GO_Central.
# GO_process	GO:0002489	antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; IBA:GO_Central.
# GO_process	GO:0002591	positive regulation of antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central.
# GO_process	GO:0015031	protein transport; IEA:UniProtKB-KW.
# GO_process	GO:0015833	peptide transport; IDA:UniProtKB.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005764	lysosome
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 1.
# Genevisible	Q9NP78	HS
# HGNC	HGNC:50	ABCB9
# INDUCTION	Not induced by interferon-gamma. {ECO:0000269|PubMed	11011155}. 
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR011527	ABC1_TM_dom
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR027417	P-loop_NTPase
# InterPro	IPR030254	ABCB9
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko02010	ABC transporters
# KEGG_Pathway	ko04142	Lysosome
# MIM	605453	gene
# Organism	ABCB9_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR24221:SF242	PTHR24221:SF242
# PROSITE	PS00211	ABC_TRANSPORTER_1
# PROSITE	PS50893	ABC_TRANSPORTER_2
# PROSITE	PS50929	ABC_TM1F
# Pfam	PF00005	ABC_tran
# Pfam	PF00664	ABC_membrane
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-382556	ABC-family proteins mediated transport
# RecName	ABCB9_HUMAN	ATP-binding cassette sub-family B member 9
# RefSeq	NP_001229942	NM_001243013.1. [Q9NP78-7]
# RefSeq	NP_001229943	NM_001243014.1. [Q9NP78-6]
# RefSeq	NP_062570	NM_019624.3. [Q9NP78-2]
# RefSeq	NP_062571	NM_019625.3. [Q9NP78-1]
# RefSeq	NP_982269	NM_203444.3. [Q9NP78-5]
# RefSeq	XP_011536397	XM_011538095.2. [Q9NP78-1]
# RefSeq	XP_011536398	XM_011538096.2. [Q9NP78-1]
# RefSeq	XP_016874592	XM_017019103.1. [Q9NP78-1]
# SEQUENCE CAUTION	Sequence=BAA96044.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD66830.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule	PRU00441}. 
# SIMILARITY	Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA
# SUBCELLULAR LOCATION	ABCB9_HUMAN	Lysosome membrane {ECO 0000269|PubMed 10748049, ECO 0000269|PubMed 15577206, ECO 0000269|PubMed 17897319, ECO 0000269|PubMed 17977821, ECO 0000269|PubMed 18175933, ECO 0000269|PubMed 18952056, ECO 0000269|PubMed 20377823, ECO 0000269|PubMed 21212514}; Multi- pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00441, ECO 0000269|PubMed 10748049, ECO 0000269|PubMed 15577206, ECO 0000269|PubMed 17897319, ECO 0000269|PubMed 17977821, ECO 0000269|PubMed 18175933, ECO 0000269|PubMed 18952056, ECO 0000269|PubMed 20377823, ECO 0000269|PubMed 21212514}. Note=May be located in membrane rafts. 
# SUBUNIT	Homodimer. {ECO:0000269|PubMed	15863492}. 
# SUPFAM	SSF52540	SSF52540
# SUPFAM	SSF90123	SSF90123
# TCDB	3.A.1.209	the atp-binding cassette (abc) superfamily
# TISSUE SPECIFICITY	ABCB9_HUMAN	Highly expressed in testis, and at moderate levels in brain, spinal cord, and thyroid. Not expressed in monocytes but strongly expressed during differentiation of monocytes to dendritic cells and macrophages. {ECO 0000269|PubMed 10748049, ECO 0000269|PubMed 17977821}. 
# UCSC	uc001udm	human. [Q9NP78-1]
# WEB RESOURCE	ABCB9_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=Q9NP78";
# eggNOG	COG1132	LUCA
# eggNOG	KOG0058	Eukaryota
BLAST	swissprot:ABCB9_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCB9_HUMAN
BioCyc	ZFISH:HS07697-MONOMER	http://biocyc.org/getid?id=ZFISH:HS07697-MONOMER
COXPRESdb	23457	http://coxpresdb.jp/data/gene/23457.shtml
CleanEx	HS_ABCB9	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCB9
DOI	10.1007/s10038-002-8653-6	http://dx.doi.org/10.1007/s10038-002-8653-6
DOI	10.1016/j.bbrc.2003.08.081	http://dx.doi.org/10.1016/j.bbrc.2003.08.081
DOI	10.1016/j.bbrc.2008.10.078	http://dx.doi.org/10.1016/j.bbrc.2008.10.078
DOI	10.1016/j.jmb.2004.09.028	http://dx.doi.org/10.1016/j.jmb.2004.09.028
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M001819200	http://dx.doi.org/10.1074/jbc.M001819200
DOI	10.1074/jbc.M503231200	http://dx.doi.org/10.1074/jbc.M503231200
DOI	10.1074/jbc.M708139200	http://dx.doi.org/10.1074/jbc.M708139200
DOI	10.1074/jbc.M801794200	http://dx.doi.org/10.1074/jbc.M801794200
DOI	10.1093/dnares/7.2.143	http://dx.doi.org/10.1093/dnares/7.2.143
DOI	10.1093/oxfordjournals.jbchem.a022805	http://dx.doi.org/10.1093/oxfordjournals.jbchem.a022805
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1600-0854.2007.00643.x	http://dx.doi.org/10.1111/j.1600-0854.2007.00643.x
DOI	10.1111/j.1600-0854.2009.01021.x	http://dx.doi.org/10.1111/j.1600-0854.2009.01021.x
DOI	10.1248/bpb.27.1916	http://dx.doi.org/10.1248/bpb.27.1916
DOI	10.1248/bpb.31.1	http://dx.doi.org/10.1248/bpb.31.1
DOI	10.1248/bpb.34.36	http://dx.doi.org/10.1248/bpb.34.36
EMBL	AB040953	http://www.ebi.ac.uk/ena/data/view/AB040953
EMBL	AB045381	http://www.ebi.ac.uk/ena/data/view/AB045381
EMBL	AB112582	http://www.ebi.ac.uk/ena/data/view/AB112582
EMBL	AB112583	http://www.ebi.ac.uk/ena/data/view/AB112583
EMBL	AB177852	http://www.ebi.ac.uk/ena/data/view/AB177852
EMBL	AC026362	http://www.ebi.ac.uk/ena/data/view/AC026362
EMBL	AC027290	http://www.ebi.ac.uk/ena/data/view/AC027290
EMBL	AF216494	http://www.ebi.ac.uk/ena/data/view/AF216494
EMBL	AK304295	http://www.ebi.ac.uk/ena/data/view/AK304295
EMBL	BC017348	http://www.ebi.ac.uk/ena/data/view/BC017348
Ensembl	ENST00000280560	http://www.ensembl.org/id/ENST00000280560
Ensembl	ENST00000344275	http://www.ensembl.org/id/ENST00000344275
Ensembl	ENST00000346530	http://www.ensembl.org/id/ENST00000346530
Ensembl	ENST00000392439	http://www.ensembl.org/id/ENST00000392439
Ensembl	ENST00000442833	http://www.ensembl.org/id/ENST00000442833
Ensembl	ENST00000540285	http://www.ensembl.org/id/ENST00000540285
Ensembl	ENST00000542678	http://www.ensembl.org/id/ENST00000542678
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030176	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030176
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0015421	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015421
GO_function	GO:0015440	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015440
GO_function	GO:0022891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022891
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_process	GO:0002481	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002481
GO_process	GO:0002485	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002485
GO_process	GO:0002489	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002489
GO_process	GO:0002591	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002591
GO_process	GO:0015031	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031
GO_process	GO:0015833	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015833
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCB9	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCB9
GeneID	23457	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23457
GeneTree	ENSGT00550000074497	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074497
HGNC	HGNC:50	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:50
HOVERGEN	HBG008358	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG008358&db=HOVERGEN
HPA	CAB033052	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB033052
HPA	HPA035114	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035114
InParanoid	Q9NP78	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NP78
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR011527	http://www.ebi.ac.uk/interpro/entry/IPR011527
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
InterPro	IPR030254	http://www.ebi.ac.uk/interpro/entry/IPR030254
Jabion	23457	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=23457
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:23457	http://www.genome.jp/dbget-bin/www_bget?hsa:23457
KEGG_Orthology	KO:K05656	http://www.genome.jp/dbget-bin/www_bget?KO:K05656
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
KEGG_Pathway	ko04142	http://www.genome.jp/kegg-bin/show_pathway?ko04142
MIM	605453	http://www.ncbi.nlm.nih.gov/omim/605453
PANTHER	PTHR24221:SF242	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24221:SF242
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PROSITE	PS50929	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929
PSORT	swissprot:ABCB9_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCB9_HUMAN
PSORT-B	swissprot:ABCB9_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCB9_HUMAN
PSORT2	swissprot:ABCB9_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCB9_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF00664	http://pfam.xfam.org/family/PF00664
PharmGKB	PA24391	http://www.pharmgkb.org/do/serve?objId=PA24391&objCls=Gene
Phobius	swissprot:ABCB9_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCB9_HUMAN
PhylomeDB	Q9NP78	http://phylomedb.org/?seqid=Q9NP78
ProteinModelPortal	Q9NP78	http://www.proteinmodelportal.org/query/uniprot/Q9NP78
PubMed	10748049	http://www.ncbi.nlm.nih.gov/pubmed/10748049
PubMed	10819331	http://www.ncbi.nlm.nih.gov/pubmed/10819331
PubMed	11011155	http://www.ncbi.nlm.nih.gov/pubmed/11011155
PubMed	11829140	http://www.ncbi.nlm.nih.gov/pubmed/11829140
PubMed	13679046	http://www.ncbi.nlm.nih.gov/pubmed/13679046
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15491607	http://www.ncbi.nlm.nih.gov/pubmed/15491607
PubMed	15577206	http://www.ncbi.nlm.nih.gov/pubmed/15577206
PubMed	15863492	http://www.ncbi.nlm.nih.gov/pubmed/15863492
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	17897319	http://www.ncbi.nlm.nih.gov/pubmed/17897319
PubMed	17977821	http://www.ncbi.nlm.nih.gov/pubmed/17977821
PubMed	18175933	http://www.ncbi.nlm.nih.gov/pubmed/18175933
PubMed	18434309	http://www.ncbi.nlm.nih.gov/pubmed/18434309
PubMed	18952056	http://www.ncbi.nlm.nih.gov/pubmed/18952056
PubMed	20377823	http://www.ncbi.nlm.nih.gov/pubmed/20377823
PubMed	21212514	http://www.ncbi.nlm.nih.gov/pubmed/21212514
Reactome	R-HSA-382556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-382556
RefSeq	NP_001229942	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001229942
RefSeq	NP_001229943	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001229943
RefSeq	NP_062570	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_062570
RefSeq	NP_062571	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_062571
RefSeq	NP_982269	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_982269
RefSeq	XP_011536397	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011536397
RefSeq	XP_011536398	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011536398
RefSeq	XP_016874592	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016874592
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	Q9NP78	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9NP78
STRING	9606.ENSP00000280560	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000280560&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
SUPFAM	SSF90123	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123
TCDB	3.A.1.209	http://www.tcdb.org/search/result.php?tc=3.A.1.209
UCSC	uc001udm	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001udm&org=rat
UniGene	Hs.511951	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.511951
UniProtKB	ABCB9_HUMAN	http://www.uniprot.org/uniprot/ABCB9_HUMAN
UniProtKB-AC	Q9NP78	http://www.uniprot.org/uniprot/Q9NP78
charge	swissprot:ABCB9_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCB9_HUMAN
eggNOG	COG1132	http://eggnogapi.embl.de/nog_data/html/tree/COG1132
eggNOG	KOG0058	http://eggnogapi.embl.de/nog_data/html/tree/KOG0058
epestfind	swissprot:ABCB9_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCB9_HUMAN
garnier	swissprot:ABCB9_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCB9_HUMAN
helixturnhelix	swissprot:ABCB9_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCB9_HUMAN
hmoment	swissprot:ABCB9_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCB9_HUMAN
iep	swissprot:ABCB9_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCB9_HUMAN
inforesidue	swissprot:ABCB9_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCB9_HUMAN
neXtProt	NX_Q9NP78	http://www.nextprot.org/db/entry/NX_Q9NP78
octanol	swissprot:ABCB9_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCB9_HUMAN
pepcoil	swissprot:ABCB9_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCB9_HUMAN
pepdigest	swissprot:ABCB9_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCB9_HUMAN
pepinfo	swissprot:ABCB9_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCB9_HUMAN
pepnet	swissprot:ABCB9_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCB9_HUMAN
pepstats	swissprot:ABCB9_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCB9_HUMAN
pepwheel	swissprot:ABCB9_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCB9_HUMAN
pepwindow	swissprot:ABCB9_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCB9_HUMAN
sigcleave	swissprot:ABCB9_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCB9_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GAR1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NY12-1; Sequence=Displayed; Name=2; IsoId=Q9NY12-2; Sequence=VSP_014594; Note=No experimental confirmation available.; 
# AltName	GAR1_HUMAN	Nucleolar protein family A member 1
# AltName	GAR1_HUMAN	snoRNP protein GAR1
# BioGrid	119949	89
# CCDS	CCDS34050	-. [Q9NY12-1]
# DOMAIN	GAR1_HUMAN	Interaction with SMN1 requires at least one of the RGG-box regions. 
# Ensembl	ENST00000226796	ENSP00000226796; ENSG00000109534. [Q9NY12-1]
# Ensembl	ENST00000394631	ENSP00000378127; ENSG00000109534. [Q9NY12-1]
# ExpressionAtlas	Q9NY12	baseline and differential
# FUNCTION	GAR1_HUMAN	Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. {ECO 0000269|PubMed 10757788, ECO 0000269|PubMed 15044956}. 
# GO_component	GO:0000784	nuclear chromosome, telomeric region; IDA:BHF-UCL.
# GO_component	GO:0005634	nucleus; IDA:HPA.
# GO_component	GO:0005654	nucleoplasm; TAS:Reactome.
# GO_component	GO:0005697	telomerase holoenzyme complex; TAS:BHF-UCL.
# GO_component	GO:0005730	nucleolus; IDA:HPA.
# GO_component	GO:0031429	box H/ACA snoRNP complex; IDA:BHF-UCL.
# GO_component	GO:0072589	box H/ACA scaRNP complex; TAS:BHF-UCL.
# GO_component	GO:0090661	box H/ACA telomerase RNP complex; IDA:BHF-UCL.
# GO_function	GO:0005261	cation channel activity; TAS:ProtInc.
# GO_function	GO:0034513	box H/ACA snoRNA binding; IPI:BHF-UCL.
# GO_function	GO:0044822	poly(A) RNA binding; IDA:UniProtKB.
# GO_function	GO:0070034	telomerase RNA binding; IPI:BHF-UCL.
# GO_process	GO:0000454	snoRNA guided rRNA pseudouridine synthesis; IBA:GO_Central.
# GO_process	GO:0007004	telomere maintenance via telomerase; TAS:BHF-UCL.
# GO_process	GO:0031118	rRNA pseudouridine synthesis; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005730	nucleolus
# GOslim_function	GO:0003723	RNA binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006259	DNA metabolic process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0051276	chromosome organization
# Genevisible	Q9NY12	HS
# HGNC	HGNC:14264	GAR1
# IntAct	Q9NY12	60
# InterPro	IPR007504	H/ACA_rnp_Gar1/Naf1
# InterPro	IPR009000	Transl_B-barrel
# InterPro	IPR021154	H/ACA_rnp_Gar1
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko03009	 M00425  H/ACA ribonucleoprotein complex
# KEGG_Brite	ko03009	 Ribosome biogenesis
# KEGG_Brite	ko03032	 DNA replication proteins
# KEGG_Brite	ko03032	 M00425  H/ACA ribonucleoprotein complex
# KEGG_Pathway	ko03008	Ribosome biogenesis in eukaryotes
# MIM	606468	gene
# Organism	GAR1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR23237	PTHR23237
# Pfam	PF04410	Gar1
# ProDom	PD020235	Gar1_RNA_bd
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-6790901	rRNA modification in the nucleus and cytosol
# RecName	GAR1_HUMAN	H/ACA ribonucleoprotein complex subunit 1
# RefSeq	NP_061856	NM_018983.3. [Q9NY12-1]
# RefSeq	NP_127460	NM_032993.2. [Q9NY12-1]
# SIMILARITY	Belongs to the GAR1 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	GAR1_HUMAN	Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies). 
# SUBUNIT	GAR1_HUMAN	Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which contains NHP2/NOLA2, GAR1/NOLA1, NOP10/NOLA3, and DKC1/NOLA4, which is presumed to be the catalytic subunit. The complex contains a stable core formed by binding of one or two NOP10-DKC1 heterodimers to NHP2; GAR1 subsequently binds to this core via DKC1. The complex binds a box H/ACA small nucleolar RNA (snoRNA), which may target the specific site of modification within the RNA substrate. The complex also interacts with TERC, which contains a 3'-terminal domain related to the box H/ACA snoRNAs. Specific interactions with snoRNAs or TERC are mediated by GAR1 and NHP2. Associates with NOLC1/NOPP140. H/ACA snoRNPs interact with the SMN complex, consisting of SMN1 or SMN2, GEMIN2/SIP1, DDX20/GEMIN3, and GEMIN4. This is mediated by interaction between GAR1 and SMN1 or SMN2. The SMN complex may be required for correct assembly of the H/ACA snoRNP complex. Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC). {ECO 0000269|PubMed 11509230, ECO 0000269|PubMed 12244096, ECO 0000269|PubMed 19179534}. 
# SUPFAM	SSF50447	SSF50447
# UCSC	uc003hzt	human. [Q9NY12-1]
# eggNOG	COG3277	LUCA
# eggNOG	KOG3262	Eukaryota
BLAST	swissprot:GAR1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GAR1_HUMAN
BioCyc	ZFISH:ENSG00000109534-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000109534-MONOMER
BioCyc	ZFISH:ENSG00000139910-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000139910-MONOMER
BioCyc	ZFISH:ENSG00000146276-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000146276-MONOMER
COXPRESdb	54433	http://coxpresdb.jp/data/gene/54433.shtml
CleanEx	HS_GAR1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GAR1
DOI	10.1016/S0960-9822(01)00316-5	http://dx.doi.org/10.1016/S0960-9822(01)00316-5
DOI	10.1016/S0960-9822(01)00650-9	http://dx.doi.org/10.1016/S0960-9822(01)00650-9
DOI	10.1038/sj.emboj.7600181	http://dx.doi.org/10.1038/sj.emboj.7600181
DOI	10.1074/jbc.M204551200	http://dx.doi.org/10.1074/jbc.M204551200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1165357	http://dx.doi.org/10.1126/science.1165357
DOI	10.1128/MCB.20.9.3037-3048.2000	http://dx.doi.org/10.1128/MCB.20.9.3037-3048.2000
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AJ276003	http://www.ebi.ac.uk/ena/data/view/AJ276003
EMBL	AY780787	http://www.ebi.ac.uk/ena/data/view/AY780787
EMBL	BC003413	http://www.ebi.ac.uk/ena/data/view/BC003413
Ensembl	ENST00000226796	http://www.ensembl.org/id/ENST00000226796
Ensembl	ENST00000394631	http://www.ensembl.org/id/ENST00000394631
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000784	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000784
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005697	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005697
GO_component	GO:0005730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005730
GO_component	GO:0031429	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031429
GO_component	GO:0072589	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072589
GO_component	GO:0090661	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090661
GO_function	GO:0005261	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005261
GO_function	GO:0034513	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034513
GO_function	GO:0044822	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044822
GO_function	GO:0070034	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070034
GO_process	GO:0000454	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000454
GO_process	GO:0007004	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007004
GO_process	GO:0031118	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031118
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005730
GOslim_function	GO:0003723	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006259	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0051276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276
GeneCards	GAR1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GAR1
GeneID	54433	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54433
GeneTree	ENSGT00730000111223	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00730000111223
HGNC	HGNC:14264	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14264
HOGENOM	HOG000112695	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000112695&db=HOGENOM6
HPA	HPA059098	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA059098
InParanoid	Q9NY12	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NY12
IntAct	Q9NY12	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NY12*
InterPro	IPR007504	http://www.ebi.ac.uk/interpro/entry/IPR007504
InterPro	IPR009000	http://www.ebi.ac.uk/interpro/entry/IPR009000
InterPro	IPR021154	http://www.ebi.ac.uk/interpro/entry/IPR021154
Jabion	54433	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=54433
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko03009	http://www.genome.jp/dbget-bin/www_bget?ko03009
KEGG_Brite	ko03009	http://www.genome.jp/dbget-bin/www_bget?ko03009
KEGG_Brite	ko03032	http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Brite	ko03032	http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Gene	hsa:54433	http://www.genome.jp/dbget-bin/www_bget?hsa:54433
KEGG_Orthology	KO:K11128	http://www.genome.jp/dbget-bin/www_bget?KO:K11128
KEGG_Pathway	ko03008	http://www.genome.jp/kegg-bin/show_pathway?ko03008
MIM	606468	http://www.ncbi.nlm.nih.gov/omim/606468
MINT	MINT-207666	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-207666
OMA	HFNAQIF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HFNAQIF
OrthoDB	EOG091G0Z6Z	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0Z6Z
PANTHER	PTHR23237	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23237
PSORT	swissprot:GAR1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GAR1_HUMAN
PSORT-B	swissprot:GAR1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GAR1_HUMAN
PSORT2	swissprot:GAR1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GAR1_HUMAN
Pfam	PF04410	http://pfam.xfam.org/family/PF04410
PharmGKB	PA164720194	http://www.pharmgkb.org/do/serve?objId=PA164720194&objCls=Gene
Phobius	swissprot:GAR1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GAR1_HUMAN
PhylomeDB	Q9NY12	http://phylomedb.org/?seqid=Q9NY12
ProteinModelPortal	Q9NY12	http://www.proteinmodelportal.org/query/uniprot/Q9NY12
PubMed	10757788	http://www.ncbi.nlm.nih.gov/pubmed/10757788
PubMed	11509230	http://www.ncbi.nlm.nih.gov/pubmed/11509230
PubMed	11790298	http://www.ncbi.nlm.nih.gov/pubmed/11790298
PubMed	12244096	http://www.ncbi.nlm.nih.gov/pubmed/12244096
PubMed	15044956	http://www.ncbi.nlm.nih.gov/pubmed/15044956
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19179534	http://www.ncbi.nlm.nih.gov/pubmed/19179534
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
Reactome	R-HSA-6790901	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6790901
RefSeq	NP_061856	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061856
RefSeq	NP_127460	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_127460
SMR	Q9NY12	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9NY12
STRING	9606.ENSP00000226796	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000226796&targetmode=cogs
SUPFAM	SSF50447	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50447
UCSC	uc003hzt	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003hzt&org=rat
UniGene	Hs.69851	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.69851
UniProtKB	GAR1_HUMAN	http://www.uniprot.org/uniprot/GAR1_HUMAN
UniProtKB-AC	Q9NY12	http://www.uniprot.org/uniprot/Q9NY12
charge	swissprot:GAR1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GAR1_HUMAN
eggNOG	COG3277	http://eggnogapi.embl.de/nog_data/html/tree/COG3277
eggNOG	KOG3262	http://eggnogapi.embl.de/nog_data/html/tree/KOG3262
epestfind	swissprot:GAR1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GAR1_HUMAN
garnier	swissprot:GAR1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GAR1_HUMAN
helixturnhelix	swissprot:GAR1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GAR1_HUMAN
hmoment	swissprot:GAR1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GAR1_HUMAN
iep	swissprot:GAR1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GAR1_HUMAN
inforesidue	swissprot:GAR1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GAR1_HUMAN
neXtProt	NX_Q9NY12	http://www.nextprot.org/db/entry/NX_Q9NY12
octanol	swissprot:GAR1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GAR1_HUMAN
pepcoil	swissprot:GAR1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GAR1_HUMAN
pepdigest	swissprot:GAR1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GAR1_HUMAN
pepinfo	swissprot:GAR1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GAR1_HUMAN
pepnet	swissprot:GAR1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GAR1_HUMAN
pepstats	swissprot:GAR1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GAR1_HUMAN
pepwheel	swissprot:GAR1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GAR1_HUMAN
pepwindow	swissprot:GAR1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GAR1_HUMAN
sigcleave	swissprot:GAR1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GAR1_HUMAN
## Database	ID	URL or Descriptions
# AltName	XPOT_HUMAN	Exportin(tRNA)
# AltName	XPOT_HUMAN	tRNA exportin
# BioGrid	116420	42
# ChiTaRS	XPOT	human
# Ensembl	ENST00000332707	ENSP00000327821; ENSG00000184575
# ExpressionAtlas	O43592	baseline and differential
# FUNCTION	XPOT_HUMAN	Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP- bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO 0000269|PubMed 12138183, ECO 0000269|PubMed 9512417, ECO 0000269|PubMed 9660920}. 
# GO_component	GO:0005654	nucleoplasm; IDA:UniProtKB.
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0016363	nuclear matrix; IBA:GO_Central.
# GO_function	GO:0000049	tRNA binding; IDA:UniProtKB.
# GO_function	GO:0008536	Ran GTPase binding; IBA:GO_Central.
# GO_function	GO:0015932	nucleobase-containing compound transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0006409	tRNA export from nucleus; IDA:UniProtKB.
# GO_process	GO:0006886	intracellular protein transport; IEA:InterPro.
# GO_process	GO:0071528	tRNA re-export from nucleus; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_function	GO:0003723	RNA binding
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# Gene3D	1.25.10.10	-; 2.
# Genevisible	O43592	HS
# HGNC	HGNC:12826	XPOT
# IntAct	O43592	23
# InterPro	IPR001494	Importin-beta_N
# InterPro	IPR011989	ARM-like
# InterPro	IPR013598	Exportin-1/Importin-b-like
# InterPro	IPR016024	ARM-type_fold
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko03016	 Transfer RNA biogenesis
# KEGG_Pathway	ko03013	RNA transport
# MIM	603180	gene
# Organism	XPOT_HUMAN	Homo sapiens (Human)
# Pfam	PF03810	IBN_N
# Pfam	PF08389	Xpo1
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-6784531	tRNA processing in the nucleus
# RecName	XPOT_HUMAN	Exportin-T
# RefSeq	NP_009166	NM_007235.4
# RefSeq	XP_016874237	XM_017018748.1
# SIMILARITY	Belongs to the exportin family. {ECO	0000305}.
# SMART	SM00913	IBN_N
# SUBCELLULAR LOCATION	XPOT_HUMAN	Nucleus. Cytoplasm. Note=Nuclear, once bound to tRNA and Ran the complex translocates to the cytoplasm. Shuttles between the nucleus and the cytoplasm. 
# SUBUNIT	XPOT_HUMAN	Found in a complex with XPOT, Ran and tRNA. Probably found in a complex with nucleoporins. Interacts with Ran and tRNA in a GTP-dependent manner. {ECO 0000269|PubMed 12138183, ECO 0000269|PubMed 9512417, ECO 0000269|PubMed 9660920}. 
# SUPFAM	SSF48371	SSF48371; 2
# TCDB	1.I.1.1	the nuclear pore complex (npc) family
# UCSC	uc001ssb	human
# eggNOG	ENOG410XZDZ	LUCA
# eggNOG	KOG2021	Eukaryota
BLAST	swissprot:XPOT_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:XPOT_HUMAN
BioCyc	ZFISH:G66-33500-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33500-MONOMER
COXPRESdb	11260	http://coxpresdb.jp/data/gene/11260.shtml
CleanEx	HS_XPOT	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_XPOT
DOI	10.1016/S0960-9822(98)70130-7	http://dx.doi.org/10.1016/S0960-9822(98)70130-7
DOI	10.1016/S1097-2765(00)80036-2	http://dx.doi.org/10.1016/S1097-2765(00)80036-2
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1074/mcp.M111.015131	http://dx.doi.org/10.1074/mcp.M111.015131
DOI	10.1093/emboj/17.24.7430	http://dx.doi.org/10.1093/emboj/17.24.7430
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1128/MCB.22.16.5708-5720.2002	http://dx.doi.org/10.1128/MCB.22.16.5708-5720.2002
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AC135279	http://www.ebi.ac.uk/ena/data/view/AC135279
EMBL	AF039022	http://www.ebi.ac.uk/ena/data/view/AF039022
EMBL	BC000950	http://www.ebi.ac.uk/ena/data/view/BC000950
EMBL	BC020569	http://www.ebi.ac.uk/ena/data/view/BC020569
EMBL	Y16414	http://www.ebi.ac.uk/ena/data/view/Y16414
Ensembl	ENST00000332707	http://www.ensembl.org/id/ENST00000332707
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0016363	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016363
GO_function	GO:0000049	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049
GO_function	GO:0008536	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008536
GO_function	GO:0015932	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015932
GO_process	GO:0006409	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006409
GO_process	GO:0006886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006886
GO_process	GO:0071528	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071528
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_function	GO:0003723	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
GeneCards	XPOT	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=XPOT
GeneID	11260	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11260
GeneTree	ENSGT00390000007890	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000007890
HGNC	HGNC:12826	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:12826
HOGENOM	HOG000007104	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007104&db=HOGENOM6
HOVERGEN	HBG094163	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG094163&db=HOVERGEN
HPA	HPA048067	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA048067
HPA	HPA057602	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA057602
InParanoid	O43592	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O43592
IntAct	O43592	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O43592*
InterPro	IPR001494	http://www.ebi.ac.uk/interpro/entry/IPR001494
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR013598	http://www.ebi.ac.uk/interpro/entry/IPR013598
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
Jabion	11260	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=11260
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko03016	http://www.genome.jp/dbget-bin/www_bget?ko03016
KEGG_Gene	hsa:11260	http://www.genome.jp/dbget-bin/www_bget?hsa:11260
KEGG_Orthology	KO:K14288	http://www.genome.jp/dbget-bin/www_bget?KO:K14288
KEGG_Pathway	ko03013	http://www.genome.jp/kegg-bin/show_pathway?ko03013
MIM	603180	http://www.ncbi.nlm.nih.gov/omim/603180
MINT	MINT-1138512	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1138512
OMA	MRYDETS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MRYDETS
OrthoDB	EOG091G04A1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G04A1
PSORT	swissprot:XPOT_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:XPOT_HUMAN
PSORT-B	swissprot:XPOT_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:XPOT_HUMAN
PSORT2	swissprot:XPOT_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:XPOT_HUMAN
Pfam	PF03810	http://pfam.xfam.org/family/PF03810
Pfam	PF08389	http://pfam.xfam.org/family/PF08389
PharmGKB	PA37419	http://www.pharmgkb.org/do/serve?objId=PA37419&objCls=Gene
Phobius	swissprot:XPOT_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:XPOT_HUMAN
PhylomeDB	O43592	http://phylomedb.org/?seqid=O43592
ProteinModelPortal	O43592	http://www.proteinmodelportal.org/query/uniprot/O43592
PubMed	12138183	http://www.ncbi.nlm.nih.gov/pubmed/12138183
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22223895	http://www.ncbi.nlm.nih.gov/pubmed/22223895
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	9512417	http://www.ncbi.nlm.nih.gov/pubmed/9512417
PubMed	9660920	http://www.ncbi.nlm.nih.gov/pubmed/9660920
PubMed	9857198	http://www.ncbi.nlm.nih.gov/pubmed/9857198
Reactome	R-HSA-6784531	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6784531
RefSeq	NP_009166	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_009166
RefSeq	XP_016874237	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016874237
SMART	SM00913	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00913
SMR	O43592	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O43592
STRING	9606.ENSP00000327821	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000327821&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
TCDB	1.I.1.1	http://www.tcdb.org/search/result.php?tc=1.I.1.1
UCSC	uc001ssb	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001ssb&org=rat
UniGene	Hs.592579	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.592579
UniGene	Hs.85951	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.85951
UniProtKB	XPOT_HUMAN	http://www.uniprot.org/uniprot/XPOT_HUMAN
UniProtKB-AC	O43592	http://www.uniprot.org/uniprot/O43592
charge	swissprot:XPOT_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:XPOT_HUMAN
eggNOG	ENOG410XZDZ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XZDZ
eggNOG	KOG2021	http://eggnogapi.embl.de/nog_data/html/tree/KOG2021
epestfind	swissprot:XPOT_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:XPOT_HUMAN
garnier	swissprot:XPOT_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:XPOT_HUMAN
helixturnhelix	swissprot:XPOT_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:XPOT_HUMAN
hmoment	swissprot:XPOT_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:XPOT_HUMAN
iep	swissprot:XPOT_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:XPOT_HUMAN
inforesidue	swissprot:XPOT_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:XPOT_HUMAN
neXtProt	NX_O43592	http://www.nextprot.org/db/entry/NX_O43592
octanol	swissprot:XPOT_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:XPOT_HUMAN
pepcoil	swissprot:XPOT_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:XPOT_HUMAN
pepdigest	swissprot:XPOT_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:XPOT_HUMAN
pepinfo	swissprot:XPOT_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:XPOT_HUMAN
pepnet	swissprot:XPOT_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:XPOT_HUMAN
pepstats	swissprot:XPOT_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:XPOT_HUMAN
pepwheel	swissprot:XPOT_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:XPOT_HUMAN
pepwindow	swissprot:XPOT_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:XPOT_HUMAN
sigcleave	swissprot:XPOT_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:XPOT_HUMAN
## Database	ID	URL or Descriptions
# CDD	cd06174	MFS
# FUNCTION	S22AV_HUMAN	Organic anion transporter that mediates the uptake of ions. {ECO 0000305}. 
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0008514	organic anion transmembrane transporter activity; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# HGNC	HGNC:27091	SLC22A31
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR020846	MFS_dom
# Organism	S22AV_HUMAN	Homo sapiens (Human)
# PROSITE	PS50850	MFS
# Pfam	PF00083	Sugar_tr
# Proteomes	UP000005640	Unplaced
# RecName	S22AV_HUMAN	Putative solute carrier family 22 member 31
# SIMILARITY	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S22AV_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.19.23	the major facilitator superfamily (mfs)
BLAST	swissprot:S22AV_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S22AV_HUMAN
DOI	10.1038/nature03187	http://dx.doi.org/10.1038/nature03187
EMBL	AC009113	http://www.ebi.ac.uk/ena/data/view/AC009113
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0008514	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008514
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GeneCards	SLC22A31	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC22A31
HGNC	HGNC:27091	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:27091
HOGENOM	HOG000015298	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000015298&db=HOGENOM6
HOVERGEN	HBG108438	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108438&db=HOVERGEN
HPA	CAB002669	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB002669
InParanoid	A6NKX4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=A6NKX4
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:S22AV_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S22AV_HUMAN
PSORT-B	swissprot:S22AV_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S22AV_HUMAN
PSORT2	swissprot:S22AV_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S22AV_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
Phobius	swissprot:S22AV_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S22AV_HUMAN
PhylomeDB	A6NKX4	http://phylomedb.org/?seqid=A6NKX4
ProteinModelPortal	A6NKX4	http://www.proteinmodelportal.org/query/uniprot/A6NKX4
PubMed	15616553	http://www.ncbi.nlm.nih.gov/pubmed/15616553
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.19.23	http://www.tcdb.org/search/result.php?tc=2.A.1.19.23
UniGene	Hs.447544	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.447544
UniGene	Hs.743726	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.743726
UniProtKB	S22AV_HUMAN	http://www.uniprot.org/uniprot/S22AV_HUMAN
UniProtKB-AC	A6NKX4	http://www.uniprot.org/uniprot/A6NKX4
charge	swissprot:S22AV_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S22AV_HUMAN
epestfind	swissprot:S22AV_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S22AV_HUMAN
garnier	swissprot:S22AV_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S22AV_HUMAN
helixturnhelix	swissprot:S22AV_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S22AV_HUMAN
hmoment	swissprot:S22AV_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S22AV_HUMAN
iep	swissprot:S22AV_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S22AV_HUMAN
inforesidue	swissprot:S22AV_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S22AV_HUMAN
neXtProt	NX_A6NKX4	http://www.nextprot.org/db/entry/NX_A6NKX4
octanol	swissprot:S22AV_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S22AV_HUMAN
pepcoil	swissprot:S22AV_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S22AV_HUMAN
pepdigest	swissprot:S22AV_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S22AV_HUMAN
pepinfo	swissprot:S22AV_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S22AV_HUMAN
pepnet	swissprot:S22AV_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S22AV_HUMAN
pepstats	swissprot:S22AV_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S22AV_HUMAN
pepwheel	swissprot:S22AV_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S22AV_HUMAN
pepwindow	swissprot:S22AV_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S22AV_HUMAN
sigcleave	swissprot:S22AV_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S22AV_HUMAN
## Database	ID	URL or Descriptions
# AltName	IMA8_HUMAN	Karyopherin subunit alpha-7
# BioGrid	135514	3
# Ensembl	ENST00000327442	ENSP00000330878; ENSG00000185467
# FUNCTION	IMA8_HUMAN	Functions in nuclear protein import. {ECO 0000250}. 
# GO_component	GO:0005643	nuclear pore; IBA:GO_Central.
# GO_component	GO:0005654	nucleoplasm; IBA:GO_Central.
# GO_component	GO:0005829	cytosol; IBA:GO_Central.
# GO_function	GO:0008139	nuclear localization sequence binding; IBA:GO_Central.
# GO_function	GO:0008565	protein transporter activity; IBA:GO_Central.
# GO_process	GO:0006607	NLS-bearing protein import into nucleus; IBA:GO_Central.
# GO_process	GO:0019054	modulation by virus of host process; TAS:Reactome.
# GO_process	GO:0075733	intracellular transport of virus; TAS:Reactome.
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# Gene3D	1.25.10.10	-; 1.
# HGNC	HGNC:21839	KPNA7
# InterPro	IPR000225	Armadillo
# InterPro	IPR002652	Importin-a_IBB
# InterPro	IPR011989	ARM-like
# InterPro	IPR016024	ARM-type_fold
# InterPro	IPR024931	Importing_su_alpha
# InterPro	IPR032413	Arm_3
# MIM	614107	gene
# Organism	IMA8_HUMAN	Homo sapiens (Human)
# Orphanet	401959	Partial corpus callosum agenesis-cerebellar vermis hypoplasia with posterior fossa cysts syndrome
# PIRSF	PIRSF005673	Importin_alpha
# PROSITE	PS50176	ARM_REPEAT; 5
# PROSITE	PS51214	IBB
# Pfam	PF00514	Arm; 7
# Pfam	PF01749	IBB
# Pfam	PF16186	Arm_3
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-1169408	ISG15 antiviral mechanism
# Reactome	R-HSA-168276	NS1 Mediated Effects on Host Pathways
# RecName	IMA8_HUMAN	Importin subunit alpha-8
# RefSeq	NP_001139187	NM_001145715.2
# SEQUENCE CAUTION	Sequence=EAL23884.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the importin alpha family. {ECO	0000305}. 
# SIMILARITY	Contains 1 IBB domain. {ECO:0000255|PROSITE- ProRule	PRU00561}. 
# SIMILARITY	Contains 8 ARM repeats. {ECO:0000255|PROSITE- ProRule	PRU00259}. 
# SMART	SM00185	ARM; 8
# SUBCELLULAR LOCATION	IMA8_HUMAN	Nucleus {ECO 0000269|PubMed 20701745}. 
# SUBUNIT	IMA8_HUMAN	Binds very efficiently to importin subunit beta-1/KPNB1 via the IBB domain; this complex dissociates in the presence of RAN-GTP. Shows a limited binding to the RB1 nuclear localization signal (NLS), but not to the SV40, nor NPM1 NLSs. 
# SUPFAM	SSF48371	SSF48371
# UCSC	uc010lft	human
# eggNOG	COG5064	LUCA
# eggNOG	KOG0166	Eukaryota
BLAST	swissprot:IMA8_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:IMA8_HUMAN
BioCyc	ZFISH:G66-32006-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32006-MONOMER
COXPRESdb	402569	http://coxpresdb.jp/data/gene/402569.shtml
DOI	10.1126/science.1083423	http://dx.doi.org/10.1126/science.1083423
DOI	10.1186/1471-2121-11-63	http://dx.doi.org/10.1186/1471-2121-11-63
EMBL	CH236956	http://www.ebi.ac.uk/ena/data/view/CH236956
EMBL	EU126604	http://www.ebi.ac.uk/ena/data/view/EU126604
Ensembl	ENST00000327442	http://www.ensembl.org/id/ENST00000327442
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005643	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005643
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_function	GO:0008139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008139
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0006607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006607
GO_process	GO:0019054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019054
GO_process	GO:0075733	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0075733
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
GeneCards	KPNA7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KPNA7
GeneID	402569	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=402569
GeneTree	ENSGT00760000119094	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119094
HGNC	HGNC:21839	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:21839
HOGENOM	HOG000167616	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000167616&db=HOGENOM6
HOVERGEN	HBG001846	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG001846&db=HOVERGEN
HPA	HPA031395	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031395
InParanoid	A9QM74	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=A9QM74
InterPro	IPR000225	http://www.ebi.ac.uk/interpro/entry/IPR000225
InterPro	IPR002652	http://www.ebi.ac.uk/interpro/entry/IPR002652
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
InterPro	IPR024931	http://www.ebi.ac.uk/interpro/entry/IPR024931
InterPro	IPR032413	http://www.ebi.ac.uk/interpro/entry/IPR032413
Jabion	402569	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=402569
KEGG_Gene	hsa:402569	http://www.genome.jp/dbget-bin/www_bget?hsa:402569
MIM	614107	http://www.ncbi.nlm.nih.gov/omim/614107
OMA	NKNPYPC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NKNPYPC
Orphanet	401959	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=401959
OrthoDB	EOG091G095Z	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G095Z
PROSITE	PS50176	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50176
PROSITE	PS51214	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51214
PSORT	swissprot:IMA8_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:IMA8_HUMAN
PSORT-B	swissprot:IMA8_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:IMA8_HUMAN
PSORT2	swissprot:IMA8_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:IMA8_HUMAN
Pfam	PF00514	http://pfam.xfam.org/family/PF00514
Pfam	PF01749	http://pfam.xfam.org/family/PF01749
Pfam	PF16186	http://pfam.xfam.org/family/PF16186
PharmGKB	PA164722048	http://www.pharmgkb.org/do/serve?objId=PA164722048&objCls=Gene
Phobius	swissprot:IMA8_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:IMA8_HUMAN
PhylomeDB	A9QM74	http://phylomedb.org/?seqid=A9QM74
ProteinModelPortal	A9QM74	http://www.proteinmodelportal.org/query/uniprot/A9QM74
PubMed	12690205	http://www.ncbi.nlm.nih.gov/pubmed/12690205
PubMed	20701745	http://www.ncbi.nlm.nih.gov/pubmed/20701745
Reactome	R-HSA-1169408	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1169408
Reactome	R-HSA-168276	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-168276
RefSeq	NP_001139187	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001139187
SMART	SM00185	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00185
SMR	A9QM74	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=A9QM74
STRING	9606.ENSP00000330878	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000330878&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
UCSC	uc010lft	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010lft&org=rat
UniGene	Hs.253050	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.253050
UniProtKB	IMA8_HUMAN	http://www.uniprot.org/uniprot/IMA8_HUMAN
UniProtKB-AC	A9QM74	http://www.uniprot.org/uniprot/A9QM74
charge	swissprot:IMA8_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:IMA8_HUMAN
eggNOG	COG5064	http://eggnogapi.embl.de/nog_data/html/tree/COG5064
eggNOG	KOG0166	http://eggnogapi.embl.de/nog_data/html/tree/KOG0166
epestfind	swissprot:IMA8_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:IMA8_HUMAN
garnier	swissprot:IMA8_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:IMA8_HUMAN
helixturnhelix	swissprot:IMA8_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:IMA8_HUMAN
hmoment	swissprot:IMA8_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:IMA8_HUMAN
iep	swissprot:IMA8_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:IMA8_HUMAN
inforesidue	swissprot:IMA8_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:IMA8_HUMAN
neXtProt	NX_A9QM74	http://www.nextprot.org/db/entry/NX_A9QM74
octanol	swissprot:IMA8_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:IMA8_HUMAN
pepcoil	swissprot:IMA8_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:IMA8_HUMAN
pepdigest	swissprot:IMA8_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:IMA8_HUMAN
pepinfo	swissprot:IMA8_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:IMA8_HUMAN
pepnet	swissprot:IMA8_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:IMA8_HUMAN
pepstats	swissprot:IMA8_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:IMA8_HUMAN
pepwheel	swissprot:IMA8_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:IMA8_HUMAN
pepwindow	swissprot:IMA8_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:IMA8_HUMAN
sigcleave	swissprot:IMA8_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:IMA8_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CAC1F_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O60840-1; Sequence=Displayed; Name=2; IsoId=O60840-2; Sequence=VSP_036785; Name=3; IsoId=O60840-4; Sequence=VSP_045172; 
# AltName	CAC1F_HUMAN	Voltage-gated calcium channel subunit alpha Cav1.4
# CCDS	CCDS35253	-. [O60840-1]
# CCDS	CCDS59166	-. [O60840-4]
# CCDS	CCDS59167	-. [O60840-2]
# ChiTaRS	CACNA1F	human
# DISEASE	CAC1F_HUMAN	Aaland island eye disease (AIED) [MIM 300600]  A retinal disease characterized by a combination of fundus hypopigmentation, decreased visual acuity due to foveal hypoplasia, nystagmus, astigmatism, protan color vision defect, myopia, and defective dark adaptation. Except for progression of axial myopia, the disease can be considered to be a stationary condition. Electroretinography reveals abnormalities in both photopic and scotopic functions. {ECO 0000269|PubMed 17525176, ECO 0000269|PubMed 22194652}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CAC1F_HUMAN	Cone-rod dystrophy, X-linked 3 (CORDX3) [MIM 300476]  An inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa. {ECO 0000269|PubMed 16505158}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CAC1F_HUMAN	Night blindness, congenital stationary, 2A (CSNB2A) [MIM 300071]  A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia. {ECO 0000269|PubMed 11281458, ECO 0000269|PubMed 12111638, ECO 0000269|PubMed 12187427, ECO 0000269|PubMed 15897456, ECO 0000269|PubMed 22194652, ECO 0000269|PubMed 9662399, ECO 0000269|PubMed 9662400}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	CAC1F_HUMAN	Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position. 
# DrugBank	DB00393	Nimodipine
# DrugBank	DB00421	Spironolactone
# DrugBank	DB00568	Cinnarizine
# DrugBank	DB00661	Verapamil
# DrugBank	DB04855	Dronedarone
# DrugBank	DB04920	Clevidipine
# Ensembl	ENST00000323022	ENSP00000321618; ENSG00000102001. [O60840-2]
# Ensembl	ENST00000376251	ENSP00000365427; ENSG00000102001. [O60840-4]
# Ensembl	ENST00000376265	ENSP00000365441; ENSG00000102001. [O60840-1]
# ExpressionAtlas	O60840	baseline and differential
# FUNCTION	CAC1F_HUMAN	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). 
# GO_component	GO:0001750	photoreceptor outer segment; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005891	voltage-gated calcium channel complex; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IDA:UniProtKB.
# GO_component	GO:0043204	perikaryon; IEA:Ensembl.
# GO_function	GO:0005245	voltage-gated calcium channel activity; IDA:UniProtKB.
# GO_function	GO:0008331	high voltage-gated calcium channel activity; IBA:GO_Central.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0007601	visual perception; IMP:UniProtKB.
# GO_process	GO:0043029	T cell homeostasis; IEA:InterPro.
# GO_process	GO:0050856	regulation of T cell receptor signaling pathway; IEA:InterPro.
# GO_process	GO:0050908	detection of light stimulus involved in visual perception; IMP:UniProtKB.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:0086010	membrane depolarization during action potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0050877	neurological system process
# Gene3D	1.20.120.350	-; 5.
# Genevisible	O60840	HS
# HGNC	HGNC:1393	CACNA1F
# IntAct	O60840	2
# InterPro	IPR002077	VDCCAlpha1
# InterPro	IPR005446	VDCC_L_a1su
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR014873	VDCC_a1su_IQ
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR030157	VDCC_L_a1F
# InterPro	IPR031649	GPHH_dom
# InterPro	IPR031688	CAC1F_C
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00481	[Inherited metabolic disease; Nervous system disease; Eye disease] Retinal cone dystrophy (RCD)
# KEGG_Disease	H00690	[Eye disease] Forsius-Eriksson syndrome
# KEGG_Disease	H00787	[Nervous system disease; Eye disease] Oguchi disease/ CSNB Oguchi type (CSNBO)
# KEGG_Pathway	ko04010	MAPK signaling pathway
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko04270	Vascular smooth muscle contraction
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04725	Cholinergic synapse
# KEGG_Pathway	ko04726	Serotonergic synapse
# KEGG_Pathway	ko04727	GABAergic synapse
# KEGG_Pathway	ko04912	GnRH signaling pathway
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05410	Hypertrophic cardiomyopathy (HCM)
# KEGG_Pathway	ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
# KEGG_Pathway	ko05414	Dilated cardiomyopathy
# MIM	300071	phenotype
# MIM	300110	gene
# MIM	300476	phenotype
# MIM	300600	phenotype
# Organism	CAC1F_HUMAN	Homo sapiens (Human)
# Orphanet	178333	Aland Islands eye disease
# Orphanet	1872	Cone rod dystrophy
# Orphanet	215	Congenital stationary night blindness
# PANTHER	PTHR10037:SF184	PTHR10037:SF184
# PRINTS	PR00167	CACHANNEL
# PRINTS	PR01630	LVDCCALPHA1
# Pfam	PF00520	Ion_trans; 4
# Pfam	PF08763	Ca_chan_IQ
# Pfam	PF16885	CAC1F_C
# Pfam	PF16905	GPHH
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# Reactome	R-HSA-5576893	Phase 2 - plateau phase
# Reactome	R-HSA-5576894	Phase 1 - inactivation of fast Na+ channels
# RecName	CAC1F_HUMAN	Voltage-dependent L-type calcium channel subunit alpha-1F
# RefSeq	NP_001243718	NM_001256789.2. [O60840-2]
# RefSeq	NP_001243719	NM_001256790.2. [O60840-4]
# RefSeq	NP_005174	NM_005183.3. [O60840-1]
# SEQUENCE CAUTION	Sequence=AAB92359.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1F subfamily. {ECO	0000305}. 
# SMART	SM01062	Ca_chan_IQ
# SUBCELLULAR LOCATION	CAC1F_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	CAC1F_HUMAN	Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1 1 1 1 ratio. The channel activity is directed by the pore- forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts (via IQ domain) with CABP4; in a calcium independent manner (By similarity). {ECO 0000250}. 
# TCDB	1.A.1.11.11	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	Expression in skeletal muscle and retina. {ECO:0000269|PubMed	10873387}. 
# UCSC	uc004dnb	human. [O60840-1]
# WEB RESOURCE	CAC1F_HUMAN	Name=Mutations of the CCNA1F gene; Note=Retina International's Scientific Newsletter; URL="http //www.retina-international.org/files/sci-news/cacnamut.htm";
# eggNOG	ENOG410XNP6	LUCA
# eggNOG	KOG2301	Eukaryota
BLAST	swissprot:CAC1F_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CAC1F_HUMAN
BioCyc	ZFISH:ENSG00000102001-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000102001-MONOMER
COXPRESdb	778	http://coxpresdb.jp/data/gene/778.shtml
CleanEx	HS_CACNA1F	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CACNA1F
DOI	10.1006/geno.1997.4941	http://dx.doi.org/10.1006/geno.1997.4941
DOI	10.1006/geno.2000.6204	http://dx.doi.org/10.1006/geno.2000.6204
DOI	10.1007/s004390100461	http://dx.doi.org/10.1007/s004390100461
DOI	10.1038/940	http://dx.doi.org/10.1038/940
DOI	10.1038/947	http://dx.doi.org/10.1038/947
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1038/sj.ejhg.5200828	http://dx.doi.org/10.1038/sj.ejhg.5200828
DOI	10.1073/pnas.0501907102	http://dx.doi.org/10.1073/pnas.0501907102
DOI	10.1076/opge.23.2.71.2214	http://dx.doi.org/10.1076/opge.23.2.71.2214
DOI	10.1086/508067	http://dx.doi.org/10.1086/508067
DOI	10.1124/mol.108.049981	http://dx.doi.org/10.1124/mol.108.049981
DOI	10.1136/jmg.2006.040741	http://dx.doi.org/10.1136/jmg.2006.040741
DOI	10.1167/iovs.06-1103	http://dx.doi.org/10.1167/iovs.06-1103
DrugBank	DB00393	http://www.drugbank.ca/drugs/DB00393
DrugBank	DB00421	http://www.drugbank.ca/drugs/DB00421
DrugBank	DB00568	http://www.drugbank.ca/drugs/DB00568
DrugBank	DB00661	http://www.drugbank.ca/drugs/DB00661
DrugBank	DB04855	http://www.drugbank.ca/drugs/DB04855
DrugBank	DB04920	http://www.drugbank.ca/drugs/DB04920
EMBL	AF067227	http://www.ebi.ac.uk/ena/data/view/AF067227
EMBL	AF196779	http://www.ebi.ac.uk/ena/data/view/AF196779
EMBL	AF201304	http://www.ebi.ac.uk/ena/data/view/AF201304
EMBL	AF235097	http://www.ebi.ac.uk/ena/data/view/AF235097
EMBL	AJ006216	http://www.ebi.ac.uk/ena/data/view/AJ006216
EMBL	AJ224874	http://www.ebi.ac.uk/ena/data/view/AJ224874
EMBL	JF701915	http://www.ebi.ac.uk/ena/data/view/JF701915
EMBL	U93305	http://www.ebi.ac.uk/ena/data/view/U93305
Ensembl	ENST00000323022	http://www.ensembl.org/id/ENST00000323022
Ensembl	ENST00000376251	http://www.ensembl.org/id/ENST00000376251
Ensembl	ENST00000376265	http://www.ensembl.org/id/ENST00000376265
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0001750	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001750
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005891
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0043204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043204
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0008331	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008331
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0007601	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007601
GO_process	GO:0043029	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043029
GO_process	GO:0050856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050856
GO_process	GO:0050908	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050908
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:0086010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086010
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	CACNA1F	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CACNA1F
GeneID	778	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=778
GeneTree	ENSGT00830000128247	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00830000128247
HGNC	HGNC:1393	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1393
HOGENOM	HOG000231529	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231529&db=HOGENOM6
HOVERGEN	HBG050763	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050763&db=HOVERGEN
InParanoid	O60840	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O60840
IntAct	O60840	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O60840*
InterPro	IPR002077	http://www.ebi.ac.uk/interpro/entry/IPR002077
InterPro	IPR005446	http://www.ebi.ac.uk/interpro/entry/IPR005446
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR014873	http://www.ebi.ac.uk/interpro/entry/IPR014873
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR030157	http://www.ebi.ac.uk/interpro/entry/IPR030157
InterPro	IPR031649	http://www.ebi.ac.uk/interpro/entry/IPR031649
InterPro	IPR031688	http://www.ebi.ac.uk/interpro/entry/IPR031688
Jabion	778	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=778
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00481	http://www.genome.jp/dbget-bin/www_bget?H00481
KEGG_Disease	H00690	http://www.genome.jp/dbget-bin/www_bget?H00690
KEGG_Disease	H00787	http://www.genome.jp/dbget-bin/www_bget?H00787
KEGG_Gene	hsa:778	http://www.genome.jp/dbget-bin/www_bget?hsa:778
KEGG_Orthology	KO:K04853	http://www.genome.jp/dbget-bin/www_bget?KO:K04853
KEGG_Pathway	ko04010	http://www.genome.jp/kegg-bin/show_pathway?ko04010
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko04270	http://www.genome.jp/kegg-bin/show_pathway?ko04270
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04725	http://www.genome.jp/kegg-bin/show_pathway?ko04725
KEGG_Pathway	ko04726	http://www.genome.jp/kegg-bin/show_pathway?ko04726
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
KEGG_Pathway	ko04912	http://www.genome.jp/kegg-bin/show_pathway?ko04912
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05410	http://www.genome.jp/kegg-bin/show_pathway?ko05410
KEGG_Pathway	ko05412	http://www.genome.jp/kegg-bin/show_pathway?ko05412
KEGG_Pathway	ko05414	http://www.genome.jp/kegg-bin/show_pathway?ko05414
MIM	300071	http://www.ncbi.nlm.nih.gov/omim/300071
MIM	300110	http://www.ncbi.nlm.nih.gov/omim/300110
MIM	300476	http://www.ncbi.nlm.nih.gov/omim/300476
MIM	300600	http://www.ncbi.nlm.nih.gov/omim/300600
OMA	DGHNAPR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DGHNAPR
Orphanet	178333	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=178333
Orphanet	1872	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1872
Orphanet	215	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=215
OrthoDB	EOG091G0TKO	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0TKO
PANTHER	PTHR10037:SF184	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10037:SF184
PRINTS	PR00167	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00167
PRINTS	PR01630	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01630
PSORT	swissprot:CAC1F_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CAC1F_HUMAN
PSORT-B	swissprot:CAC1F_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CAC1F_HUMAN
PSORT2	swissprot:CAC1F_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CAC1F_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF08763	http://pfam.xfam.org/family/PF08763
Pfam	PF16885	http://pfam.xfam.org/family/PF16885
Pfam	PF16905	http://pfam.xfam.org/family/PF16905
PharmGKB	PA26010	http://www.pharmgkb.org/do/serve?objId=PA26010&objCls=Gene
Phobius	swissprot:CAC1F_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CAC1F_HUMAN
PhylomeDB	O60840	http://phylomedb.org/?seqid=O60840
ProteinModelPortal	O60840	http://www.proteinmodelportal.org/query/uniprot/O60840
PubMed	10873387	http://www.ncbi.nlm.nih.gov/pubmed/10873387
PubMed	11281458	http://www.ncbi.nlm.nih.gov/pubmed/11281458
PubMed	12111638	http://www.ncbi.nlm.nih.gov/pubmed/12111638
PubMed	12187427	http://www.ncbi.nlm.nih.gov/pubmed/12187427
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	15897456	http://www.ncbi.nlm.nih.gov/pubmed/15897456
PubMed	16505158	http://www.ncbi.nlm.nih.gov/pubmed/16505158
PubMed	16960802	http://www.ncbi.nlm.nih.gov/pubmed/16960802
PubMed	17525176	http://www.ncbi.nlm.nih.gov/pubmed/17525176
PubMed	19029287	http://www.ncbi.nlm.nih.gov/pubmed/19029287
PubMed	22194652	http://www.ncbi.nlm.nih.gov/pubmed/22194652
PubMed	9344658	http://www.ncbi.nlm.nih.gov/pubmed/9344658
PubMed	9662399	http://www.ncbi.nlm.nih.gov/pubmed/9662399
PubMed	9662400	http://www.ncbi.nlm.nih.gov/pubmed/9662400
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
Reactome	R-HSA-5576893	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576893
Reactome	R-HSA-5576894	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576894
RefSeq	NP_001243718	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243718
RefSeq	NP_001243719	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243719
RefSeq	NP_005174	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005174
SMART	SM01062	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01062
STRING	9606.ENSP00000365441	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000365441&targetmode=cogs
TCDB	1.A.1.11.11	http://www.tcdb.org/search/result.php?tc=1.A.1.11.11
UCSC	uc004dnb	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004dnb&org=rat
UniGene	Hs.632799	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.632799
UniProtKB	CAC1F_HUMAN	http://www.uniprot.org/uniprot/CAC1F_HUMAN
UniProtKB-AC	O60840	http://www.uniprot.org/uniprot/O60840
charge	swissprot:CAC1F_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CAC1F_HUMAN
eggNOG	ENOG410XNP6	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNP6
eggNOG	KOG2301	http://eggnogapi.embl.de/nog_data/html/tree/KOG2301
epestfind	swissprot:CAC1F_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CAC1F_HUMAN
garnier	swissprot:CAC1F_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CAC1F_HUMAN
helixturnhelix	swissprot:CAC1F_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CAC1F_HUMAN
hmoment	swissprot:CAC1F_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CAC1F_HUMAN
iep	swissprot:CAC1F_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CAC1F_HUMAN
inforesidue	swissprot:CAC1F_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CAC1F_HUMAN
neXtProt	NX_O60840	http://www.nextprot.org/db/entry/NX_O60840
octanol	swissprot:CAC1F_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CAC1F_HUMAN
pepcoil	swissprot:CAC1F_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CAC1F_HUMAN
pepdigest	swissprot:CAC1F_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CAC1F_HUMAN
pepinfo	swissprot:CAC1F_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CAC1F_HUMAN
pepnet	swissprot:CAC1F_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CAC1F_HUMAN
pepstats	swissprot:CAC1F_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CAC1F_HUMAN
pepwheel	swissprot:CAC1F_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CAC1F_HUMAN
pepwindow	swissprot:CAC1F_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CAC1F_HUMAN
sigcleave	swissprot:CAC1F_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CAC1F_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CACB2_HUMAN	Event=Alternative splicing; Named isoforms=10; Name=2d; Synonyms=CACNB2d; IsoId=Q08289-1; Sequence=Displayed; Name=2a; Synonyms=CACNB2a; IsoId=Q08289-2; Sequence=VSP_000627; Name=2b; Synonyms=CACNB2b, 2aN4; IsoId=Q08289-3; Sequence=VSP_000628; Name=2c; Synonyms=CACNB2c, 2aN2; IsoId=Q08289-4; Sequence=VSP_000626; Name=2e; Synonyms=CACNB2e; IsoId=Q08289-5; Sequence=VSP_000629; Name=2f; IsoId=Q08289-6; Sequence=VSP_000627, VSP_000630; Name=2g; IsoId=Q08289-7; Sequence=VSP_000630; Name=2h; Synonyms=2cN1; IsoId=Q08289-8; Sequence=VSP_000631; Name=2cN2; IsoId=Q08289-9; Sequence=VSP_000626, VSP_000631; Name=2cN4; IsoId=Q08289-10; Sequence=VSP_000628, VSP_000631; 
# AltName	CACB2_HUMAN	Calcium channel voltage-dependent subunit beta 2
# AltName	CACB2_HUMAN	Lambert-Eaton myasthenic syndrome antigen B
# BioGrid	107237	2
# CCDS	CCDS41493	-. [Q08289-9]
# CCDS	CCDS41494	-. [Q08289-3]
# CCDS	CCDS7125	-. [Q08289-1]
# CCDS	CCDS7126	-. [Q08289-8]
# CCDS	CCDS7127	-. [Q08289-4]
# CCDS	CCDS7128	-. [Q08289-2]
# CCDS	CCDS7129	-. [Q08289-5]
# CCDS	CCDS81442	-. [Q08289-6]
# ChiTaRS	CACNB2	human
# DISEASE	CACB2_HUMAN	Brugada syndrome 4 (BRGDA4) [MIM 611876]  A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset. {ECO 0000269|PubMed 17224476}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00270	Isradipine
# DrugBank	DB00381	Amlodipine
# DrugBank	DB00393	Nimodipine
# DrugBank	DB00401	Nisoldipine
# DrugBank	DB00421	Spironolactone
# DrugBank	DB00622	Nicardipine
# DrugBank	DB00653	Magnesium Sulfate
# DrugBank	DB00661	Verapamil
# DrugBank	DB01023	Felodipine
# DrugBank	DB01054	Nitrendipine
# DrugBank	DB01115	Nifedipine
# DrugBank	DB04855	Dronedarone
# DrugBank	DB06712	Nilvadipine
# Ensembl	ENST00000282343	ENSP00000282343; ENSG00000165995. [Q08289-4]
# Ensembl	ENST00000324631	ENSP00000320025; ENSG00000165995. [Q08289-1]
# Ensembl	ENST00000352115	ENSP00000344474; ENSG00000165995. [Q08289-8]
# Ensembl	ENST00000377315	ENSP00000366532; ENSG00000165995. [Q08289-5]
# Ensembl	ENST00000377319	ENSP00000366536; ENSG00000165995. [Q08289-6]
# Ensembl	ENST00000377329	ENSP00000366546; ENSG00000165995. [Q08289-3]
# Ensembl	ENST00000377331	ENSP00000366548; ENSG00000165995. [Q08289-9]
# Ensembl	ENST00000396576	ENSP00000379821; ENSG00000165995. [Q08289-2]
# ExpressionAtlas	Q08289	baseline and differential
# FUNCTION	CACB2_HUMAN	The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; NAS:UniProtKB.
# GO_component	GO:0005891	voltage-gated calcium channel complex; IDA:BHF-UCL.
# GO_component	GO:1990454	L-type voltage-gated calcium channel complex; IDA:BHF-UCL.
# GO_function	GO:0005245	voltage-gated calcium channel activity; IDA:BHF-UCL.
# GO_function	GO:0005262	calcium channel activity; NAS:UniProtKB.
# GO_function	GO:0051015	actin filament binding; ISS:BHF-UCL.
# GO_process	GO:0007268	chemical synaptic transmission; IBA:GO_Central.
# GO_process	GO:0007528	neuromuscular junction development; TAS:ProtInc.
# GO_process	GO:0007601	visual perception; IEA:Ensembl.
# GO_process	GO:0051928	positive regulation of calcium ion transport; IDA:BHF-UCL.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:0070509	calcium ion import; IDA:BHF-UCL.
# GO_process	GO:0086045	membrane depolarization during AV node cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086091	regulation of heart rate by cardiac conduction; IMP:BHF-UCL.
# GO_process	GO:0090002	establishment of protein localization to plasma membrane; ISS:BHF-UCL.
# GO_process	GO:0098912	membrane depolarization during atrial cardiac muscle cell action potential; IMP:BHF-UCL.
# GO_process	GO:1901385	regulation of voltage-gated calcium channel activity; IBA:GO_Central.
# GO_process	GO:1901843	positive regulation of high voltage-gated calcium channel activity; ISS:BHF-UCL.
# GO_process	GO:1904879	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; ISS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0008092	cytoskeletal protein binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# Gene3D	3.40.50.300	-; 1.
# Genevisible	Q08289	HS
# HGNC	HGNC:1402	CACNB2
# IntAct	Q08289	3
# InterPro	IPR000584	VDCC_L_bsu
# InterPro	IPR001452	SH3_domain
# InterPro	IPR005444	VDCC_L_b2su
# InterPro	IPR008145	GK/Ca_channel_bsu
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00728	[Cardiovascular disease] Brugada syndrome (BRS)
# KEGG_Pathway	ko04010	MAPK signaling pathway
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05410	Hypertrophic cardiomyopathy (HCM)
# KEGG_Pathway	ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
# KEGG_Pathway	ko05414	Dilated cardiomyopathy
# MIM	600003	gene
# MIM	611876	phenotype
# Organism	CACB2_HUMAN	Homo sapiens (Human)
# Orphanet	130	Brugada syndrome
# PANTHER	PTHR11824	PTHR11824
# PIR	A48895	A48895
# PRINTS	PR01626	LCACHANNELB
# PRINTS	PR01628	LCACHANNELB2
# PROSITE	PS50002	SH3
# PTM	CACB2_HUMAN	Regulated through phosphorylation at Thr-554 by CaMK2D. {ECO 0000250}. 
# Pfam	PF00625	Guanylate_kin
# Pfam	PF12052	VGCC_beta4Aa_N
# Proteomes	UP000005640	Chromosome 10
# Reactome	R-HSA-112308	Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
# Reactome	R-HSA-400042	Adrenaline,noradrenaline inhibits insulin secretion
# Reactome	R-HSA-419037	NCAM1 interactions
# Reactome	R-HSA-422356	Regulation of insulin secretion
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# Reactome	R-HSA-5576893	Phase 2 - plateau phase
# Reactome	R-HSA-5576894	Phase 1 - inactivation of fast Na+ channels
# RecName	CACB2_HUMAN	Voltage-dependent L-type calcium channel subunit beta-2
# RefSeq	NP_000715	NM_000724.3. [Q08289-2]
# RefSeq	NP_001316989	NM_001330060.1
# RefSeq	NP_963864	NM_201570.2. [Q08289-5]
# RefSeq	NP_963865	NM_201571.3. [Q08289-4]
# RefSeq	NP_963866	NM_201572.3. [Q08289-9]
# RefSeq	NP_963884	NM_201590.2. [Q08289-3]
# RefSeq	NP_963887	NM_201593.2. [Q08289-7]
# RefSeq	NP_963890	NM_201596.2. [Q08289-1]
# RefSeq	NP_963891	NM_201597.2. [Q08289-8]
# RefSeq	XP_011517961	XM_011519659.2. [Q08289-10]
# SEQUENCE CAUTION	Sequence=AAB51370.1; Type=Frameshift; Positions=515; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the calcium channel beta subunit family. {ECO	0000305}. 
# SIMILARITY	Contains 1 SH3 domain. {ECO:0000255|PROSITE- ProRule	PRU00192}. 
# SMART	SM00072	GuKc
# SMART	SM00326	SH3
# SUBCELLULAR LOCATION	CACB2_HUMAN	Cell membrane, sarcolemma {ECO 0000250}; Peripheral membrane protein {ECO 0000250}; Cytoplasmic side {ECO 0000250}. 
# SUBUNIT	CACB2_HUMAN	The L-type calcium channel is composed of four subunits  alpha-1, alpha-2, beta and gamma. Interacts with CAMK2D (By similarity). Interacts with RRAD. Interaction with RRAD regulates the trafficking of CACNA1C to the cell membrane. Interacts with TMIGD2. Interacts with CBARP. {ECO 0000250, ECO 0000269|PubMed 17525370, ECO 0000269|PubMed 22419821}. 
# SUPFAM	SSF50044	SSF50044; 2
# SUPFAM	SSF52540	SSF52540
# TCDB	8.A.22.1	the ca(2+) channel auxiliary subunit types 1-4 (cca-) family
# TISSUE SPECIFICITY	CACB2_HUMAN	Expressed in all tissues. 
# UCSC	uc001ipr	human. [Q08289-1]
# eggNOG	ENOG410XRDI	LUCA
# eggNOG	KOG3812	Eukaryota
BLAST	swissprot:CACB2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CACB2_HUMAN
BioCyc	ZFISH:ENSG00000165995-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000165995-MONOMER
COXPRESdb	783	http://coxpresdb.jp/data/gene/783.shtml
DOI	10.1002/ana.410330126	http://dx.doi.org/10.1002/ana.410330126
DOI	10.1007/s004390050482	http://dx.doi.org/10.1007/s004390050482
DOI	10.1038/nature02462	http://dx.doi.org/10.1038/nature02462
DOI	10.1091/mbc.E11-11-0934	http://dx.doi.org/10.1091/mbc.E11-11-0934
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1113/jphysiol.2002.018515	http://dx.doi.org/10.1113/jphysiol.2002.018515
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1152/physiolgenomics.00207.2003	http://dx.doi.org/10.1152/physiolgenomics.00207.2003
DOI	10.1161/CIRCRESAHA.106.146399	http://dx.doi.org/10.1161/CIRCRESAHA.106.146399
DOI	10.1161/CIRCULATIONAHA.106.668392	http://dx.doi.org/10.1161/CIRCULATIONAHA.106.668392
DrugBank	DB00270	http://www.drugbank.ca/drugs/DB00270
DrugBank	DB00381	http://www.drugbank.ca/drugs/DB00381
DrugBank	DB00393	http://www.drugbank.ca/drugs/DB00393
DrugBank	DB00401	http://www.drugbank.ca/drugs/DB00401
DrugBank	DB00421	http://www.drugbank.ca/drugs/DB00421
DrugBank	DB00622	http://www.drugbank.ca/drugs/DB00622
DrugBank	DB00653	http://www.drugbank.ca/drugs/DB00653
DrugBank	DB00661	http://www.drugbank.ca/drugs/DB00661
DrugBank	DB01023	http://www.drugbank.ca/drugs/DB01023
DrugBank	DB01054	http://www.drugbank.ca/drugs/DB01054
DrugBank	DB01115	http://www.drugbank.ca/drugs/DB01115
DrugBank	DB04855	http://www.drugbank.ca/drugs/DB04855
DrugBank	DB06712	http://www.drugbank.ca/drugs/DB06712
EMBL	AF137376	http://www.ebi.ac.uk/ena/data/view/AF137376
EMBL	AF137377	http://www.ebi.ac.uk/ena/data/view/AF137377
EMBL	AF285239	http://www.ebi.ac.uk/ena/data/view/AF285239
EMBL	AF423189	http://www.ebi.ac.uk/ena/data/view/AF423189
EMBL	AF423190	http://www.ebi.ac.uk/ena/data/view/AF423190
EMBL	AF423191	http://www.ebi.ac.uk/ena/data/view/AF423191
EMBL	AF423192	http://www.ebi.ac.uk/ena/data/view/AF423192
EMBL	AF465485	http://www.ebi.ac.uk/ena/data/view/AF465485
EMBL	AL139814	http://www.ebi.ac.uk/ena/data/view/AL139814
EMBL	AL139814	http://www.ebi.ac.uk/ena/data/view/AL139814
EMBL	AL139814	http://www.ebi.ac.uk/ena/data/view/AL139814
EMBL	AL139814	http://www.ebi.ac.uk/ena/data/view/AL139814
EMBL	AL139814	http://www.ebi.ac.uk/ena/data/view/AL139814
EMBL	AL139814	http://www.ebi.ac.uk/ena/data/view/AL139814
EMBL	AL139814	http://www.ebi.ac.uk/ena/data/view/AL139814
EMBL	AL139814	http://www.ebi.ac.uk/ena/data/view/AL139814
EMBL	AL139814	http://www.ebi.ac.uk/ena/data/view/AL139814
EMBL	AL139814	http://www.ebi.ac.uk/ena/data/view/AL139814
EMBL	AL139814	http://www.ebi.ac.uk/ena/data/view/AL139814
EMBL	AL139814	http://www.ebi.ac.uk/ena/data/view/AL139814
EMBL	AL139814	http://www.ebi.ac.uk/ena/data/view/AL139814
EMBL	AL139814	http://www.ebi.ac.uk/ena/data/view/AL139814
EMBL	AL139814	http://www.ebi.ac.uk/ena/data/view/AL139814
EMBL	AL139814	http://www.ebi.ac.uk/ena/data/view/AL139814
EMBL	AL139814	http://www.ebi.ac.uk/ena/data/view/AL139814
EMBL	AL139814	http://www.ebi.ac.uk/ena/data/view/AL139814
EMBL	AL139814	http://www.ebi.ac.uk/ena/data/view/AL139814
EMBL	AL139814	http://www.ebi.ac.uk/ena/data/view/AL139814
EMBL	AL139814	http://www.ebi.ac.uk/ena/data/view/AL139814
EMBL	AL139814	http://www.ebi.ac.uk/ena/data/view/AL139814
EMBL	AL139814	http://www.ebi.ac.uk/ena/data/view/AL139814
EMBL	AL139814	http://www.ebi.ac.uk/ena/data/view/AL139814
EMBL	AL139814	http://www.ebi.ac.uk/ena/data/view/AL139814
EMBL	AL139814	http://www.ebi.ac.uk/ena/data/view/AL139814
EMBL	AL139814	http://www.ebi.ac.uk/ena/data/view/AL139814
EMBL	AL139814	http://www.ebi.ac.uk/ena/data/view/AL139814
EMBL	AL353603	http://www.ebi.ac.uk/ena/data/view/AL353603
EMBL	AL360231	http://www.ebi.ac.uk/ena/data/view/AL360231
EMBL	AL360231	http://www.ebi.ac.uk/ena/data/view/AL360231
EMBL	AL360231	http://www.ebi.ac.uk/ena/data/view/AL360231
EMBL	AL360231	http://www.ebi.ac.uk/ena/data/view/AL360231
EMBL	AL360231	http://www.ebi.ac.uk/ena/data/view/AL360231
EMBL	AL360231	http://www.ebi.ac.uk/ena/data/view/AL360231
EMBL	AL360231	http://www.ebi.ac.uk/ena/data/view/AL360231
EMBL	AL360231	http://www.ebi.ac.uk/ena/data/view/AL360231
EMBL	AL360231	http://www.ebi.ac.uk/ena/data/view/AL360231
EMBL	AL360231	http://www.ebi.ac.uk/ena/data/view/AL360231
EMBL	AL360231	http://www.ebi.ac.uk/ena/data/view/AL360231
EMBL	AL360231	http://www.ebi.ac.uk/ena/data/view/AL360231
EMBL	AL360231	http://www.ebi.ac.uk/ena/data/view/AL360231
EMBL	AL360231	http://www.ebi.ac.uk/ena/data/view/AL360231
EMBL	AL360231	http://www.ebi.ac.uk/ena/data/view/AL360231
EMBL	AL360231	http://www.ebi.ac.uk/ena/data/view/AL360231
EMBL	AL390783	http://www.ebi.ac.uk/ena/data/view/AL390783
EMBL	AL390783	http://www.ebi.ac.uk/ena/data/view/AL390783
EMBL	AL390783	http://www.ebi.ac.uk/ena/data/view/AL390783
EMBL	AL390783	http://www.ebi.ac.uk/ena/data/view/AL390783
EMBL	AL390783	http://www.ebi.ac.uk/ena/data/view/AL390783
EMBL	AL390783	http://www.ebi.ac.uk/ena/data/view/AL390783
EMBL	AL390783	http://www.ebi.ac.uk/ena/data/view/AL390783
EMBL	AL390783	http://www.ebi.ac.uk/ena/data/view/AL390783
EMBL	AL390783	http://www.ebi.ac.uk/ena/data/view/AL390783
EMBL	AL390783	http://www.ebi.ac.uk/ena/data/view/AL390783
EMBL	AL390783	http://www.ebi.ac.uk/ena/data/view/AL390783
EMBL	AL390783	http://www.ebi.ac.uk/ena/data/view/AL390783
EMBL	AL450364	http://www.ebi.ac.uk/ena/data/view/AL450364
EMBL	AL450364	http://www.ebi.ac.uk/ena/data/view/AL450364
EMBL	AL450364	http://www.ebi.ac.uk/ena/data/view/AL450364
EMBL	AL450364	http://www.ebi.ac.uk/ena/data/view/AL450364
EMBL	AL450364	http://www.ebi.ac.uk/ena/data/view/AL450364
EMBL	AL450364	http://www.ebi.ac.uk/ena/data/view/AL450364
EMBL	AL450364	http://www.ebi.ac.uk/ena/data/view/AL450364
EMBL	AL450364	http://www.ebi.ac.uk/ena/data/view/AL450364
EMBL	AL450364	http://www.ebi.ac.uk/ena/data/view/AL450364
EMBL	AL450364	http://www.ebi.ac.uk/ena/data/view/AL450364
EMBL	AL450364	http://www.ebi.ac.uk/ena/data/view/AL450364
EMBL	AL450364	http://www.ebi.ac.uk/ena/data/view/AL450364
EMBL	AL450364	http://www.ebi.ac.uk/ena/data/view/AL450364
EMBL	AL450364	http://www.ebi.ac.uk/ena/data/view/AL450364
EMBL	AL450364	http://www.ebi.ac.uk/ena/data/view/AL450364
EMBL	AL450364	http://www.ebi.ac.uk/ena/data/view/AL450364
EMBL	AL450364	http://www.ebi.ac.uk/ena/data/view/AL450364
EMBL	AL450364	http://www.ebi.ac.uk/ena/data/view/AL450364
EMBL	AL450364	http://www.ebi.ac.uk/ena/data/view/AL450364
EMBL	AL450364	http://www.ebi.ac.uk/ena/data/view/AL450364
EMBL	AL450364	http://www.ebi.ac.uk/ena/data/view/AL450364
EMBL	AL450364	http://www.ebi.ac.uk/ena/data/view/AL450364
EMBL	AL450364	http://www.ebi.ac.uk/ena/data/view/AL450364
EMBL	AL450364	http://www.ebi.ac.uk/ena/data/view/AL450364
EMBL	AL450364	http://www.ebi.ac.uk/ena/data/view/AL450364
EMBL	AL450364	http://www.ebi.ac.uk/ena/data/view/AL450364
EMBL	AL450364	http://www.ebi.ac.uk/ena/data/view/AL450364
EMBL	AL450364	http://www.ebi.ac.uk/ena/data/view/AL450364
EMBL	AL450384	http://www.ebi.ac.uk/ena/data/view/AL450384
EMBL	AL450384	http://www.ebi.ac.uk/ena/data/view/AL450384
EMBL	AL450384	http://www.ebi.ac.uk/ena/data/view/AL450384
EMBL	AL450384	http://www.ebi.ac.uk/ena/data/view/AL450384
EMBL	AL450384	http://www.ebi.ac.uk/ena/data/view/AL450384
EMBL	AL450384	http://www.ebi.ac.uk/ena/data/view/AL450384
EMBL	AL450384	http://www.ebi.ac.uk/ena/data/view/AL450384
EMBL	AL450384	http://www.ebi.ac.uk/ena/data/view/AL450384
EMBL	AL450384	http://www.ebi.ac.uk/ena/data/view/AL450384
EMBL	AL450384	http://www.ebi.ac.uk/ena/data/view/AL450384
EMBL	AL450384	http://www.ebi.ac.uk/ena/data/view/AL450384
EMBL	AL450384	http://www.ebi.ac.uk/ena/data/view/AL450384
EMBL	AL450384	http://www.ebi.ac.uk/ena/data/view/AL450384
EMBL	AL450384	http://www.ebi.ac.uk/ena/data/view/AL450384
EMBL	AL450384	http://www.ebi.ac.uk/ena/data/view/AL450384
EMBL	AL450384	http://www.ebi.ac.uk/ena/data/view/AL450384
EMBL	AL450384	http://www.ebi.ac.uk/ena/data/view/AL450384
EMBL	AL450384	http://www.ebi.ac.uk/ena/data/view/AL450384
EMBL	AL450384	http://www.ebi.ac.uk/ena/data/view/AL450384
EMBL	AL450384	http://www.ebi.ac.uk/ena/data/view/AL450384
EMBL	AL450384	http://www.ebi.ac.uk/ena/data/view/AL450384
EMBL	AL450384	http://www.ebi.ac.uk/ena/data/view/AL450384
EMBL	AL450384	http://www.ebi.ac.uk/ena/data/view/AL450384
EMBL	AL450384	http://www.ebi.ac.uk/ena/data/view/AL450384
EMBL	AL450384	http://www.ebi.ac.uk/ena/data/view/AL450384
EMBL	AL450384	http://www.ebi.ac.uk/ena/data/view/AL450384
EMBL	AL450384	http://www.ebi.ac.uk/ena/data/view/AL450384
EMBL	AL450384	http://www.ebi.ac.uk/ena/data/view/AL450384
EMBL	AY027893	http://www.ebi.ac.uk/ena/data/view/AY027893
EMBL	AY027894	http://www.ebi.ac.uk/ena/data/view/AY027894
EMBL	AY027895	http://www.ebi.ac.uk/ena/data/view/AY027895
EMBL	AY027896	http://www.ebi.ac.uk/ena/data/view/AY027896
EMBL	AY027897	http://www.ebi.ac.uk/ena/data/view/AY027897
EMBL	AY027898	http://www.ebi.ac.uk/ena/data/view/AY027898
EMBL	AY393858	http://www.ebi.ac.uk/ena/data/view/AY393858
EMBL	AY393859	http://www.ebi.ac.uk/ena/data/view/AY393859
EMBL	AY393860	http://www.ebi.ac.uk/ena/data/view/AY393860
EMBL	AY393861	http://www.ebi.ac.uk/ena/data/view/AY393861
EMBL	AY393862	http://www.ebi.ac.uk/ena/data/view/AY393862
EMBL	BC136409	http://www.ebi.ac.uk/ena/data/view/BC136409
EMBL	CH471072	http://www.ebi.ac.uk/ena/data/view/CH471072
EMBL	CH471072	http://www.ebi.ac.uk/ena/data/view/CH471072
EMBL	S60415	http://www.ebi.ac.uk/ena/data/view/S60415
EMBL	U95019	http://www.ebi.ac.uk/ena/data/view/U95019
Ensembl	ENST00000282343	http://www.ensembl.org/id/ENST00000282343
Ensembl	ENST00000324631	http://www.ensembl.org/id/ENST00000324631
Ensembl	ENST00000352115	http://www.ensembl.org/id/ENST00000352115
Ensembl	ENST00000377315	http://www.ensembl.org/id/ENST00000377315
Ensembl	ENST00000377319	http://www.ensembl.org/id/ENST00000377319
Ensembl	ENST00000377329	http://www.ensembl.org/id/ENST00000377329
Ensembl	ENST00000377331	http://www.ensembl.org/id/ENST00000377331
Ensembl	ENST00000396576	http://www.ensembl.org/id/ENST00000396576
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005891
GO_component	GO:1990454	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990454
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0051015	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051015
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007528	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007528
GO_process	GO:0007601	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007601
GO_process	GO:0051928	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051928
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:0070509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070509
GO_process	GO:0086045	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086045
GO_process	GO:0086091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086091
GO_process	GO:0090002	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090002
GO_process	GO:0098912	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098912
GO_process	GO:1901385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901385
GO_process	GO:1901843	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901843
GO_process	GO:1904879	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1904879
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0008092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	CACNB2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CACNB2
GeneID	783	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=783
GeneTree	ENSGT00390000002740	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002740
HGNC	HGNC:1402	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1402
HOGENOM	HOG000230979	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230979&db=HOGENOM6
HOVERGEN	HBG050765	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050765&db=HOVERGEN
HPA	HPA035325	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035325
HPA	HPA035326	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035326
InParanoid	Q08289	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q08289
IntAct	Q08289	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q08289*
InterPro	IPR000584	http://www.ebi.ac.uk/interpro/entry/IPR000584
InterPro	IPR001452	http://www.ebi.ac.uk/interpro/entry/IPR001452
InterPro	IPR005444	http://www.ebi.ac.uk/interpro/entry/IPR005444
InterPro	IPR008145	http://www.ebi.ac.uk/interpro/entry/IPR008145
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	783	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=783
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00728	http://www.genome.jp/dbget-bin/www_bget?H00728
KEGG_Gene	hsa:783	http://www.genome.jp/dbget-bin/www_bget?hsa:783
KEGG_Orthology	KO:K04863	http://www.genome.jp/dbget-bin/www_bget?KO:K04863
KEGG_Pathway	ko04010	http://www.genome.jp/kegg-bin/show_pathway?ko04010
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05410	http://www.genome.jp/kegg-bin/show_pathway?ko05410
KEGG_Pathway	ko05412	http://www.genome.jp/kegg-bin/show_pathway?ko05412
KEGG_Pathway	ko05414	http://www.genome.jp/kegg-bin/show_pathway?ko05414
MIM	600003	http://www.ncbi.nlm.nih.gov/omim/600003
MIM	611876	http://www.ncbi.nlm.nih.gov/omim/611876
OMA	YCDKDGE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YCDKDGE
Orphanet	130	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=130
OrthoDB	EOG091G09C1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G09C1
PANTHER	PTHR11824	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11824
PRINTS	PR01626	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01626
PRINTS	PR01628	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01628
PROSITE	PS50002	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50002
PSORT	swissprot:CACB2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CACB2_HUMAN
PSORT-B	swissprot:CACB2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CACB2_HUMAN
PSORT2	swissprot:CACB2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CACB2_HUMAN
Pfam	PF00625	http://pfam.xfam.org/family/PF00625
Pfam	PF12052	http://pfam.xfam.org/family/PF12052
PharmGKB	PA88	http://www.pharmgkb.org/do/serve?objId=PA88&objCls=Gene
Phobius	swissprot:CACB2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CACB2_HUMAN
PhylomeDB	Q08289	http://phylomedb.org/?seqid=Q08289
ProteinModelPortal	Q08289	http://www.proteinmodelportal.org/query/uniprot/Q08289
PubMed	12042350	http://www.ncbi.nlm.nih.gov/pubmed/12042350
PubMed	14762176	http://www.ncbi.nlm.nih.gov/pubmed/14762176
PubMed	15164054	http://www.ncbi.nlm.nih.gov/pubmed/15164054
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	17224476	http://www.ncbi.nlm.nih.gov/pubmed/17224476
PubMed	17525370	http://www.ncbi.nlm.nih.gov/pubmed/17525370
PubMed	22419821	http://www.ncbi.nlm.nih.gov/pubmed/22419821
PubMed	8494331	http://www.ncbi.nlm.nih.gov/pubmed/8494331
PubMed	9254841	http://www.ncbi.nlm.nih.gov/pubmed/9254841
Reactome	R-HSA-112308	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112308
Reactome	R-HSA-400042	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-400042
Reactome	R-HSA-419037	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-419037
Reactome	R-HSA-422356	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-422356
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
Reactome	R-HSA-5576893	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576893
Reactome	R-HSA-5576894	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576894
RefSeq	NP_000715	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000715
RefSeq	NP_001316989	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001316989
RefSeq	NP_963864	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_963864
RefSeq	NP_963865	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_963865
RefSeq	NP_963866	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_963866
RefSeq	NP_963884	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_963884
RefSeq	NP_963887	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_963887
RefSeq	NP_963890	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_963890
RefSeq	NP_963891	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_963891
RefSeq	XP_011517961	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011517961
SMART	SM00072	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00072
SMART	SM00326	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00326
SMR	Q08289	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q08289
STRING	9606.ENSP00000320025	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000320025&targetmode=cogs
SUPFAM	SSF50044	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50044
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TCDB	8.A.22.1	http://www.tcdb.org/search/result.php?tc=8.A.22.1
UCSC	uc001ipr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001ipr&org=rat
UniGene	Hs.59093	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.59093
UniProtKB	CACB2_HUMAN	http://www.uniprot.org/uniprot/CACB2_HUMAN
UniProtKB-AC	Q08289	http://www.uniprot.org/uniprot/Q08289
charge	swissprot:CACB2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CACB2_HUMAN
eggNOG	ENOG410XRDI	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRDI
eggNOG	KOG3812	http://eggnogapi.embl.de/nog_data/html/tree/KOG3812
epestfind	swissprot:CACB2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CACB2_HUMAN
garnier	swissprot:CACB2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CACB2_HUMAN
helixturnhelix	swissprot:CACB2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CACB2_HUMAN
hmoment	swissprot:CACB2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CACB2_HUMAN
iep	swissprot:CACB2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CACB2_HUMAN
inforesidue	swissprot:CACB2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CACB2_HUMAN
neXtProt	NX_Q08289	http://www.nextprot.org/db/entry/NX_Q08289
octanol	swissprot:CACB2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CACB2_HUMAN
pepcoil	swissprot:CACB2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CACB2_HUMAN
pepdigest	swissprot:CACB2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CACB2_HUMAN
pepinfo	swissprot:CACB2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CACB2_HUMAN
pepnet	swissprot:CACB2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CACB2_HUMAN
pepstats	swissprot:CACB2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CACB2_HUMAN
pepwheel	swissprot:CACB2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CACB2_HUMAN
pepwindow	swissprot:CACB2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CACB2_HUMAN
sigcleave	swissprot:CACB2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CACB2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	REST_HUMAN	Event=Alternative splicing; Named isoforms=4; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q13127-1; Sequence=Displayed; Name=2; IsoId=Q13127-2; Sequence=VSP_022064, VSP_022065; Name=3; Synonyms=N4; IsoId=Q13127-3; Sequence=VSP_022066, VSP_022068; Name=4; IsoId=Q13127-4; Sequence=VSP_022067; 
# AltName	REST_HUMAN	Neural-restrictive silencer factor
# AltName	REST_HUMAN	X2 box repressor
# BioGrid	111910	43
# CCDS	CCDS3509	-. [Q13127-1]
# ChiTaRS	REST	human
# DISEASE	REST_HUMAN	Wilms tumor 6 (WT6) [MIM 616806]  A pediatric malignancy of kidney, and the most common childhood abdominal malignancy. It is caused by the uncontrolled multiplication of renal stem, stromal, and epithelial cells. {ECO 0000269|PubMed 26551668}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# Ensembl	ENST00000309042	ENSP00000311816; ENSG00000084093. [Q13127-1]
# Ensembl	ENST00000619101	ENSP00000484836; ENSG00000084093. [Q13127-1]
# ExpressionAtlas	Q13127	baseline and differential
# FUNCTION	REST_HUMAN	Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression. {ECO 0000269|PubMed 12399542, ECO 0000269|PubMed 19061646, ECO 0000269|PubMed 26551668, ECO 0000269|PubMed 7697725, ECO 0000269|PubMed 7871435, ECO 0000269|PubMed 8568247}. 
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005654	nucleoplasm; TAS:Reactome.
# GO_component	GO:0005829	cytosol; IEA:Ensembl.
# GO_component	GO:0017053	transcriptional repressor complex; IDA:UniProtKB.
# GO_function	GO:0001046	core promoter sequence-specific DNA binding; IDA:UniProtKB.
# GO_function	GO:0001047	core promoter binding; IDA:UniProtKB.
# GO_function	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding; IDA:UniProtKB.
# GO_function	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding; IEA:Ensembl.
# GO_function	GO:0003682	chromatin binding; ISS:UniProtKB.
# GO_function	GO:0003700	transcription factor activity, sequence-specific DNA binding; IDA:UniProtKB.
# GO_function	GO:0004407	histone deacetylase activity; TAS:Reactome.
# GO_function	GO:0008134	transcription factor binding; IPI:UniProtKB.
# GO_function	GO:0015271	outward rectifier potassium channel activity; IMP:UniProtKB.
# GO_function	GO:0044212	transcription regulatory region DNA binding; IDA:UniProtKB.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0000122	negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
# GO_process	GO:0002244	hematopoietic progenitor cell differentiation; IEA:Ensembl.
# GO_process	GO:0006355	regulation of transcription, DNA-templated; NAS:UniProtKB.
# GO_process	GO:0008285	negative regulation of cell proliferation; IMP:UniProtKB.
# GO_process	GO:0010629	negative regulation of gene expression; IMP:UniProtKB.
# GO_process	GO:0032348	negative regulation of aldosterone biosynthetic process; IMP:UniProtKB.
# GO_process	GO:0035690	cellular response to drug; IMP:UniProtKB.
# GO_process	GO:0043065	positive regulation of apoptotic process; IMP:UniProtKB.
# GO_process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB.
# GO_process	GO:0043922	negative regulation by host of viral transcription; IDA:UniProtKB.
# GO_process	GO:0045665	negative regulation of neuron differentiation; IMP:UniProtKB.
# GO_process	GO:0045892	negative regulation of transcription, DNA-templated; IDA:UniProtKB.
# GO_process	GO:0045893	positive regulation of transcription, DNA-templated; IDA:UniProtKB.
# GO_process	GO:0045955	negative regulation of calcium ion-dependent exocytosis; ISS:UniProtKB.
# GO_process	GO:0046676	negative regulation of insulin secretion; IMP:UniProtKB.
# GO_process	GO:0050768	negative regulation of neurogenesis; ISS:UniProtKB.
# GO_process	GO:0060379	cardiac muscle cell myoblast differentiation; ISS:UniProtKB.
# GO_process	GO:0070933	histone H4 deacetylation; IDA:UniProtKB.
# GO_process	GO:0071257	cellular response to electrical stimulus; IMP:UniProtKB.
# GO_process	GO:0071385	cellular response to glucocorticoid stimulus; IDA:UniProtKB.
# GO_process	GO:2000065	negative regulation of cortisol biosynthetic process; IMP:UniProtKB.
# GO_process	GO:2000706	negative regulation of dense core granule biogenesis; ISS:UniProtKB.
# GO_process	GO:2000740	negative regulation of mesenchymal stem cell differentiation; IMP:UniProtKB.
# GO_process	GO:2000798	negative regulation of amniotic stem cell differentiation; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_function	GO:0001071	nucleic acid binding transcription factor activity
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0003677	DNA binding
# GOslim_function	GO:0008134	transcription factor binding
# GOslim_function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0030154	cell differentiation
# Gene3D	3.30.160.60	-; 4.
# Genevisible	Q13127	HS
# HGNC	HGNC:9966	REST
# INTERACTION	REST_HUMAN	P51532 SMARCA4; NbExp=2; IntAct=EBI-926706, EBI-302489; 
# IntAct	Q13127	5
# InterPro	IPR007087	Znf_C2H2
# InterPro	IPR013087	Znf_C2H2/integrase_DNA-bd
# InterPro	IPR015880	Znf_C2H2-like
# InterPro	IPR027757	REST
# InterPro	IPR027775	C2H2_Znf_fam
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko03000	 Transcription factors
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	600571	gene
# MIM	616806	phenotype
# Organism	REST_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10032	PTHR10032; 2
# PANTHER	PTHR10032:SF71	PTHR10032:SF71; 2
# PDB	2CZY	NMR; -; B=43-57
# PIR	A56138	A56138
# PIR	I38754	I38754
# PIR	I38755	I38755
# PROSITE	PS00028	ZINC_FINGER_C2H2_1
# PROSITE	PS50157	ZINC_FINGER_C2H2_2; 6
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-3214815	HDACs deacetylate histones
# RecName	REST_HUMAN	RE1-silencing transcription factor
# RefSeq	NP_001180437	NM_001193508.1. [Q13127-1]
# RefSeq	NP_005603	NM_005612.4. [Q13127-1]
# RefSeq	XP_011532703	XM_011534401.2. [Q13127-1]
# SEQUENCE CAUTION	REST_HUMAN	Sequence=AAA98503.1; Type=Frameshift; Positions=188, 198, 202, 212, 1087; Evidence={ECO 0000305}; Sequence=AAC50114.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=AAC50115.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=AAH38985.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO 0000305}; Sequence=BAD92987.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; 
# SIMILARITY	Contains 9 C2H2-type zinc fingers. {ECO:0000255|PROSITE-ProRule	PRU00042}. 
# SMART	SM00355	ZnF_C2H2; 9
# SUBCELLULAR LOCATION	REST_HUMAN	Nucleus {ECO 0000250|UniProtKB Q8VIG1}. Note=Colocalizes with ZFP90 in the nucleus. {ECO 0000250|UniProtKB Q8VIG1}. 
# SUBUNIT	REST_HUMAN	Interacts with SIN3A, SIN3B and RCOR1. Interacts with CDYL. Interacts with EHMT1 and EHMT2 only in the presence of CDYL. Part of a complex containing at least CDYL, REST, WIZ, SETB1, EHMT1 and EHMT2. Interacts (via zinc-finger DNA-binding domain) with ZFP90 (via N- and C-termini); the interaction inhibits REST repressor activity (PubMed 21284946). {ECO 0000269|PubMed 10449787, ECO 0000269|PubMed 10734093, ECO 0000269|PubMed 16288918, ECO 0000269|PubMed 19061646, ECO 0000269|PubMed 21284946}. 
# TISSUE SPECIFICITY	Ubiquitous. Expressed at higher levels in the tissues of the lymphocytic compartment, including spleen, thymus, peripheral blood lymphocytes and ovary. {ECO:0000269|PubMed	8568247}. 
# UCSC	uc003hch	human. [Q13127-1]
# WEB RESOURCE	REST_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/RESTID44266ch4q12.html";
# eggNOG	COG5048	LUCA
# eggNOG	KOG1721	Eukaryota
BLAST	swissprot:REST_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:REST_HUMAN
BioCyc	ZFISH:ENSG00000130779-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000130779-MONOMER
COXPRESdb	5978	http://coxpresdb.jp/data/gene/5978.shtml
CleanEx	HS_REST	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_REST
DIP	DIP-35264N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35264N
DOI	10.1016/0092-8674(95)90298-8	http://dx.doi.org/10.1016/0092-8674(95)90298-8
DOI	10.1016/S0169-328X(99)00196-5	http://dx.doi.org/10.1016/S0169-328X(99)00196-5
DOI	10.1016/j.jmb.2005.10.008	http://dx.doi.org/10.1016/j.jmb.2005.10.008
DOI	10.1016/j.molcel.2008.10.025	http://dx.doi.org/10.1016/j.molcel.2008.10.025
DOI	10.1016/j.yjmcc.2011.01.017	http://dx.doi.org/10.1016/j.yjmcc.2011.01.017
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng.3440	http://dx.doi.org/10.1038/ng.3440
DOI	10.1073/pnas.96.17.9873	http://dx.doi.org/10.1073/pnas.96.17.9873
DOI	10.1074/jbc.275.13.9461	http://dx.doi.org/10.1074/jbc.275.13.9461
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1076469	http://dx.doi.org/10.1126/science.1076469
DOI	10.1126/science.7871435	http://dx.doi.org/10.1126/science.7871435
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
EMBL	AB209750	http://www.ebi.ac.uk/ena/data/view/AB209750
EMBL	AC069307	http://www.ebi.ac.uk/ena/data/view/AC069307
EMBL	BC038985	http://www.ebi.ac.uk/ena/data/view/BC038985
EMBL	BC132859	http://www.ebi.ac.uk/ena/data/view/BC132859
EMBL	BC136491	http://www.ebi.ac.uk/ena/data/view/BC136491
EMBL	CH471057	http://www.ebi.ac.uk/ena/data/view/CH471057
EMBL	U13877	http://www.ebi.ac.uk/ena/data/view/U13877
EMBL	U13879	http://www.ebi.ac.uk/ena/data/view/U13879
EMBL	U22314	http://www.ebi.ac.uk/ena/data/view/U22314
EMBL	U22680	http://www.ebi.ac.uk/ena/data/view/U22680
Ensembl	ENST00000309042	http://www.ensembl.org/id/ENST00000309042
Ensembl	ENST00000619101	http://www.ensembl.org/id/ENST00000619101
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0017053	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017053
GO_function	GO:0001046	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001046
GO_function	GO:0001047	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001047
GO_function	GO:0001078	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001078
GO_function	GO:0001228	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001228
GO_function	GO:0003682	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003682
GO_function	GO:0003700	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700
GO_function	GO:0004407	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004407
GO_function	GO:0008134	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008134
GO_function	GO:0015271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015271
GO_function	GO:0044212	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044212
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0000122	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000122
GO_process	GO:0002244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002244
GO_process	GO:0006355	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355
GO_process	GO:0008285	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008285
GO_process	GO:0010629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010629
GO_process	GO:0032348	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032348
GO_process	GO:0035690	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035690
GO_process	GO:0043065	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043065
GO_process	GO:0043280	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043280
GO_process	GO:0043922	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043922
GO_process	GO:0045665	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045665
GO_process	GO:0045892	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892
GO_process	GO:0045893	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893
GO_process	GO:0045955	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045955
GO_process	GO:0046676	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046676
GO_process	GO:0050768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050768
GO_process	GO:0060379	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060379
GO_process	GO:0070933	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070933
GO_process	GO:0071257	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071257
GO_process	GO:0071385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071385
GO_process	GO:2000065	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000065
GO_process	GO:2000706	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000706
GO_process	GO:2000740	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000740
GO_process	GO:2000798	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000798
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_function	GO:0001071	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0003677	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_function	GO:0008134	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008134
GOslim_function	GO:0016810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
Gene3D	3.30.160.60	http://www.cathdb.info/version/latest/superfamily/3.30.160.60
GeneCards	REST	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=REST
GeneID	5978	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5978
GeneTree	ENSGT00850000132304	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00850000132304
H-InvDB	HIX0031381	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0031381
HGNC	HGNC:9966	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:9966
HOVERGEN	HBG093893	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG093893&db=HOVERGEN
HPA	CAB068222	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB068222
HPA	HPA006079	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA006079
InParanoid	Q13127	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q13127
IntAct	Q13127	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q13127*
InterPro	IPR007087	http://www.ebi.ac.uk/interpro/entry/IPR007087
InterPro	IPR013087	http://www.ebi.ac.uk/interpro/entry/IPR013087
InterPro	IPR015880	http://www.ebi.ac.uk/interpro/entry/IPR015880
InterPro	IPR027757	http://www.ebi.ac.uk/interpro/entry/IPR027757
InterPro	IPR027775	http://www.ebi.ac.uk/interpro/entry/IPR027775
Jabion	5978	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=5978
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko03000	http://www.genome.jp/dbget-bin/www_bget?ko03000
KEGG_Gene	hsa:5978	http://www.genome.jp/dbget-bin/www_bget?hsa:5978
KEGG_Orthology	KO:K09222	http://www.genome.jp/dbget-bin/www_bget?KO:K09222
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	600571	http://www.ncbi.nlm.nih.gov/omim/600571
MIM	616806	http://www.ncbi.nlm.nih.gov/omim/616806
OMA	HSHEGSD	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HSHEGSD
OrthoDB	EOG091G01NI	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01NI
PANTHER	PTHR10032	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10032
PANTHER	PTHR10032:SF71	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10032:SF71
PDB	2CZY	http://www.ebi.ac.uk/pdbe-srv/view/entry/2CZY
PDBsum	2CZY	http://www.ebi.ac.uk/pdbsum/2CZY
PROSITE	PS00028	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00028
PROSITE	PS50157	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50157
PSORT	swissprot:REST_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:REST_HUMAN
PSORT-B	swissprot:REST_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:REST_HUMAN
PSORT2	swissprot:REST_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:REST_HUMAN
PharmGKB	PA34334	http://www.pharmgkb.org/do/serve?objId=PA34334&objCls=Gene
Phobius	swissprot:REST_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:REST_HUMAN
PhylomeDB	Q13127	http://phylomedb.org/?seqid=Q13127
ProteinModelPortal	Q13127	http://www.proteinmodelportal.org/query/uniprot/Q13127
PubMed	10449787	http://www.ncbi.nlm.nih.gov/pubmed/10449787
PubMed	10521596	http://www.ncbi.nlm.nih.gov/pubmed/10521596
PubMed	10734093	http://www.ncbi.nlm.nih.gov/pubmed/10734093
PubMed	12399542	http://www.ncbi.nlm.nih.gov/pubmed/12399542
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	16288918	http://www.ncbi.nlm.nih.gov/pubmed/16288918
PubMed	19061646	http://www.ncbi.nlm.nih.gov/pubmed/19061646
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21284946	http://www.ncbi.nlm.nih.gov/pubmed/21284946
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	26551668	http://www.ncbi.nlm.nih.gov/pubmed/26551668
PubMed	7697725	http://www.ncbi.nlm.nih.gov/pubmed/7697725
PubMed	7871435	http://www.ncbi.nlm.nih.gov/pubmed/7871435
PubMed	8568247	http://www.ncbi.nlm.nih.gov/pubmed/8568247
Reactome	R-HSA-3214815	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3214815
RefSeq	NP_001180437	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001180437
RefSeq	NP_005603	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005603
RefSeq	XP_011532703	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011532703
SMART	SM00355	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00355
SMR	Q13127	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q13127
STRING	9606.ENSP00000311816	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000311816&targetmode=cogs
UCSC	uc003hch	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003hch&org=rat
UniGene	Hs.307836	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.307836
UniProtKB	REST_HUMAN	http://www.uniprot.org/uniprot/REST_HUMAN
UniProtKB-AC	Q13127	http://www.uniprot.org/uniprot/Q13127
charge	swissprot:REST_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:REST_HUMAN
eggNOG	COG5048	http://eggnogapi.embl.de/nog_data/html/tree/COG5048
eggNOG	KOG1721	http://eggnogapi.embl.de/nog_data/html/tree/KOG1721
epestfind	swissprot:REST_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:REST_HUMAN
garnier	swissprot:REST_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:REST_HUMAN
helixturnhelix	swissprot:REST_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:REST_HUMAN
hmoment	swissprot:REST_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:REST_HUMAN
iep	swissprot:REST_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:REST_HUMAN
inforesidue	swissprot:REST_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:REST_HUMAN
neXtProt	NX_Q13127	http://www.nextprot.org/db/entry/NX_Q13127
octanol	swissprot:REST_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:REST_HUMAN
pepcoil	swissprot:REST_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:REST_HUMAN
pepdigest	swissprot:REST_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:REST_HUMAN
pepinfo	swissprot:REST_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:REST_HUMAN
pepnet	swissprot:REST_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:REST_HUMAN
pepstats	swissprot:REST_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:REST_HUMAN
pepwheel	swissprot:REST_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:REST_HUMAN
pepwindow	swissprot:REST_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:REST_HUMAN
sigcleave	swissprot:REST_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:REST_HUMAN
## Database	ID	URL or Descriptions
# Ensembl	ENST00000284288	ENSP00000284288; ENSG00000154143
# FUNCTION	PANX3_HUMAN	Structural component of the gap junctions and the hemichannels. 
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0005921	gap junction; IEA:UniProtKB-SubCell.
# GO_component	GO:0012505	endomembrane system; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0022829	wide pore channel activity; IBA:GO_Central.
# GO_function	GO:0055077	gap junction hemi-channel activity; ISS:UniProtKB.
# GO_process	GO:0006812	cation transport; IBA:GO_Central.
# GO_process	GO:0007267	cell-cell signaling; IBA:GO_Central.
# GO_process	GO:0034214	protein hexamerization; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# Genevisible	Q96QZ0	HS
# HGNC	HGNC:20573	PANX3
# InterPro	IPR000990	Innexin
# KEGG_Brite	ko02000	Transporters
# MIM	608422	gene
# Organism	PANX3_HUMAN	Homo sapiens (Human)
# PROSITE	PS51013	PANNEXIN
# Pfam	PF00876	Innexin
# Proteomes	UP000005640	Chromosome 11
# RecName	PANX3_HUMAN	Pannexin-3
# RefSeq	NP_443191	NM_052959.2
# SIMILARITY	Belongs to the pannexin family. {ECO:0000255|PROSITE- ProRule	PRU00351}. 
# SUBCELLULAR LOCATION	PANX3_HUMAN	Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00351}. Cell junction, gap junction. 
# TCDB	1.A.25.2	the gap junction-forming innexin (innexin) family
# UCSC	uc001qah	human
# WEB RESOURCE	PANX3_HUMAN	Name=Wikipedia; Note=Pannexin entry; URL="https //en.wikipedia.org/wiki/Pannexin";
# eggNOG	ENOG410IE65	Eukaryota
# eggNOG	ENOG410ZSQN	LUCA
BLAST	swissprot:PANX3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:PANX3_HUMAN
COXPRESdb	116337	http://coxpresdb.jp/data/gene/116337.shtml
CleanEx	HS_PANX3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_PANX3
DOI	10.1016/j.ygeno.2003.09.025	http://dx.doi.org/10.1016/j.ygeno.2003.09.025
EMBL	AF406650	http://www.ebi.ac.uk/ena/data/view/AF406650
Ensembl	ENST00000284288	http://www.ensembl.org/id/ENST00000284288
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005921	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005921
GO_component	GO:0012505	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0012505
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0022829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022829
GO_function	GO:0055077	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055077
GO_process	GO:0006812	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006812
GO_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GO_process	GO:0034214	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034214
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GeneCards	PANX3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=PANX3
GeneID	116337	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=116337
GeneTree	ENSGT00390000009703	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000009703
HGNC	HGNC:20573	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20573
HOGENOM	HOG000063721	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000063721&db=HOGENOM6
HOVERGEN	HBG053497	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053497&db=HOVERGEN
InParanoid	Q96QZ0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96QZ0
IntAct	Q96QZ0	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96QZ0*
InterPro	IPR000990	http://www.ebi.ac.uk/interpro/entry/IPR000990
Jabion	116337	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=116337
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:116337	http://www.genome.jp/dbget-bin/www_bget?hsa:116337
KEGG_Orthology	KO:K03443	http://www.genome.jp/dbget-bin/www_bget?KO:K03443
MIM	608422	http://www.ncbi.nlm.nih.gov/omim/608422
OMA	KMFPYSL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KMFPYSL
OrthoDB	EOG091G086D	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G086D
PROSITE	PS51013	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51013
PSORT	swissprot:PANX3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:PANX3_HUMAN
PSORT-B	swissprot:PANX3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:PANX3_HUMAN
PSORT2	swissprot:PANX3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:PANX3_HUMAN
Pfam	PF00876	http://pfam.xfam.org/family/PF00876
PharmGKB	PA134920643	http://www.pharmgkb.org/do/serve?objId=PA134920643&objCls=Gene
Phobius	swissprot:PANX3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:PANX3_HUMAN
PhylomeDB	Q96QZ0	http://phylomedb.org/?seqid=Q96QZ0
ProteinModelPortal	Q96QZ0	http://www.proteinmodelportal.org/query/uniprot/Q96QZ0
PubMed	15028292	http://www.ncbi.nlm.nih.gov/pubmed/15028292
RefSeq	NP_443191	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_443191
SMR	Q96QZ0	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q96QZ0
STRING	9606.ENSP00000284288	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000284288&targetmode=cogs
TCDB	1.A.25.2	http://www.tcdb.org/search/result.php?tc=1.A.25.2
UCSC	uc001qah	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001qah&org=rat
UniGene	Hs.99235	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.99235
UniProtKB	PANX3_HUMAN	http://www.uniprot.org/uniprot/PANX3_HUMAN
UniProtKB-AC	Q96QZ0	http://www.uniprot.org/uniprot/Q96QZ0
charge	swissprot:PANX3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:PANX3_HUMAN
eggNOG	ENOG410IE65	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IE65
eggNOG	ENOG410ZSQN	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZSQN
epestfind	swissprot:PANX3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:PANX3_HUMAN
garnier	swissprot:PANX3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:PANX3_HUMAN
helixturnhelix	swissprot:PANX3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:PANX3_HUMAN
hmoment	swissprot:PANX3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:PANX3_HUMAN
iep	swissprot:PANX3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:PANX3_HUMAN
inforesidue	swissprot:PANX3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:PANX3_HUMAN
neXtProt	NX_Q96QZ0	http://www.nextprot.org/db/entry/NX_Q96QZ0
octanol	swissprot:PANX3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:PANX3_HUMAN
pepcoil	swissprot:PANX3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:PANX3_HUMAN
pepdigest	swissprot:PANX3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:PANX3_HUMAN
pepinfo	swissprot:PANX3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:PANX3_HUMAN
pepnet	swissprot:PANX3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:PANX3_HUMAN
pepstats	swissprot:PANX3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:PANX3_HUMAN
pepwheel	swissprot:PANX3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:PANX3_HUMAN
pepwindow	swissprot:PANX3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:PANX3_HUMAN
sigcleave	swissprot:PANX3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:PANX3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S19A1_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P41440-1; Sequence=Displayed; Name=2; IsoId=P41440-2; Sequence=VSP_042891; Note=No experimental confirmation available.; Name=3; IsoId=P41440-3; Sequence=VSP_044497; Note=No experimental confirmation available.; 
# AltName	S19A1_HUMAN	Intestinal folate carrier 1
# AltName	S19A1_HUMAN	Placental folate transporter
# AltName	S19A1_HUMAN	Reduced folate carrier protein
# AltName	S19A1_HUMAN	Solute carrier family 19 member 1
# BioGrid	112461	3
# CCDS	CCDS13725	-. [P41440-1]
# CCDS	CCDS56217	-. [P41440-2]
# CCDS	CCDS56218	-. [P41440-3]
# CDD	cd06174	MFS
# DrugBank	DB00563	Methotrexate
# DrugBank	DB06813	Pralatrexate
# Ensembl	ENST00000311124	ENSP00000308895; ENSG00000173638. [P41440-1]
# Ensembl	ENST00000380010	ENSP00000369347; ENSG00000173638. [P41440-3]
# Ensembl	ENST00000485649	ENSP00000441772; ENSG00000173638. [P41440-2]
# ExpressionAtlas	P41440	baseline and differential
# FUNCTION	S19A1_HUMAN	Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H(+)-pump. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016323	basolateral plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0016324	apical plasma membrane; IDA:BHF-UCL.
# GO_function	GO:0005542	folic acid binding; IBA:GO_Central.
# GO_function	GO:0008517	folic acid transporter activity; ISS:BHF-UCL.
# GO_function	GO:0008518	reduced folate carrier activity; IDA:BHF-UCL.
# GO_function	GO:0015350	methotrexate transporter activity; TAS:ProtInc.
# GO_process	GO:0015884	folic acid transport; ISS:BHF-UCL.
# GO_process	GO:0046655	folic acid metabolic process; TAS:Reactome.
# GO_process	GO:0098838	reduced folate transmembrane transport; IDA:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0051186	cofactor metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P41440	HS
# HGNC	HGNC:10937	SLC19A1
# IntAct	P41440	2
# InterPro	IPR002666	Folate_carrier
# InterPro	IPR020846	MFS_dom
# InterPro	IPR028339	RFC
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04977	Vitamin digestion and absorption
# MIM	600424	gene
# Organism	S19A1_HUMAN	Homo sapiens (Human)
# Orphanet	306574	Methotrexate dose selection
# PANTHER	PTHR10686	PTHR10686
# PANTHER	PTHR10686:SF12	PTHR10686:SF12
# PIR	I38924	I38924
# PIR	I52728	I52728
# PIRSF	PIRSF028739	Folate_carrier
# PIRSF	PIRSF500793	Folate_transporter_1
# PTM	S19A1_HUMAN	Heavily glycosylated. 
# Pfam	PF01770	Folate_carrier
# Proteomes	UP000005640	Chromosome 21
# Reactome	R-HSA-196757	Metabolism of folate and pterines
# RecName	S19A1_HUMAN	Folate transporter 1
# RefSeq	NP_001192135	NM_001205206.1. [P41440-3]
# RefSeq	NP_001192136	NM_001205207.1. [P41440-2]
# RefSeq	NP_919231	NM_194255.2. [P41440-1]
# RefSeq	XP_011528002	XM_011529700.2. [P41440-1]
# RefSeq	XP_011528003	XM_011529701.2. [P41440-1]
# RefSeq	XP_011528004	XM_011529702.2. [P41440-1]
# RefSeq	XP_011528005	XM_011529703.2. [P41440-1]
# RefSeq	XP_011528006	XM_011529704.2. [P41440-1]
# RefSeq	XP_016883935	XM_017028446.1. [P41440-3]
# SIMILARITY	Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S19A1_HUMAN	Membrane; Multi-pass membrane protein. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.48.1	the reduced folate carrier (rfc) family
# TIGRFAMs	TIGR00806	rfc
# TISSUE SPECIFICITY	S19A1_HUMAN	Placenta, liver, and to a much smaller extent, in lung. 
# UCSC	uc002zhl	human. [P41440-1]
# eggNOG	ENOG410XT34	LUCA
# eggNOG	KOG3810	Eukaryota
BLAST	swissprot:S19A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S19A1_HUMAN
BioCyc	ZFISH:ENSG00000173638-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000173638-MONOMER
COXPRESdb	6573	http://coxpresdb.jp/data/gene/6573.shtml
CleanEx	HS_FLOT1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_FLOT1
CleanEx	HS_RFC1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_RFC1
CleanEx	HS_SLC19A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC19A1
DOI	10.1006/bbrc.1995.1096	http://dx.doi.org/10.1006/bbrc.1995.1096
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/35012518	http://dx.doi.org/10.1038/35012518
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1053/gast.1997.v112.pm9041240	http://dx.doi.org/10.1053/gast.1997.v112.pm9041240
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1074/jbc.270.29.17468	http://dx.doi.org/10.1074/jbc.270.29.17468
DOI	10.1074/jbc.270.7.2987	http://dx.doi.org/10.1074/jbc.270.7.2987
DOI	10.1074/jbc.274.23.16269	http://dx.doi.org/10.1074/jbc.274.23.16269
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DrugBank	DB00563	http://www.drugbank.ca/drugs/DB00563
DrugBank	DB06813	http://www.drugbank.ca/drugs/DB06813
EMBL	AF004354	http://www.ebi.ac.uk/ena/data/view/AF004354
EMBL	AK303168	http://www.ebi.ac.uk/ena/data/view/AK303168
EMBL	AK313125	http://www.ebi.ac.uk/ena/data/view/AK313125
EMBL	AL163302	http://www.ebi.ac.uk/ena/data/view/AL163302
EMBL	BC003068	http://www.ebi.ac.uk/ena/data/view/BC003068
EMBL	BX322561	http://www.ebi.ac.uk/ena/data/view/BX322561
EMBL	CH471079	http://www.ebi.ac.uk/ena/data/view/CH471079
EMBL	S78996	http://www.ebi.ac.uk/ena/data/view/S78996
EMBL	U15939	http://www.ebi.ac.uk/ena/data/view/U15939
EMBL	U17566	http://www.ebi.ac.uk/ena/data/view/U17566
EMBL	U19720	http://www.ebi.ac.uk/ena/data/view/U19720
EMBL	U92869	http://www.ebi.ac.uk/ena/data/view/U92869
EMBL	U92870	http://www.ebi.ac.uk/ena/data/view/U92870
EMBL	U92871	http://www.ebi.ac.uk/ena/data/view/U92871
EMBL	U92872	http://www.ebi.ac.uk/ena/data/view/U92872
EMBL	U92873	http://www.ebi.ac.uk/ena/data/view/U92873
Ensembl	ENST00000311124	http://www.ensembl.org/id/ENST00000311124
Ensembl	ENST00000380010	http://www.ensembl.org/id/ENST00000380010
Ensembl	ENST00000485649	http://www.ensembl.org/id/ENST00000485649
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_function	GO:0005542	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005542
GO_function	GO:0008517	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008517
GO_function	GO:0008518	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008518
GO_function	GO:0015350	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015350
GO_process	GO:0015884	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015884
GO_process	GO:0046655	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046655
GO_process	GO:0098838	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098838
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0051186	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC19A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC19A1
GeneID	6573	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6573
GeneTree	ENSGT00510000046382	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00510000046382
HGNC	HGNC:10937	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10937
HOGENOM	HOG000001583	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000001583&db=HOGENOM6
HOVERGEN	HBG054198	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054198&db=HOVERGEN
HPA	HPA024802	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA024802
InParanoid	P41440	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P41440
IntAct	P41440	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P41440*
InterPro	IPR002666	http://www.ebi.ac.uk/interpro/entry/IPR002666
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
InterPro	IPR028339	http://www.ebi.ac.uk/interpro/entry/IPR028339
Jabion	6573	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6573
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6573	http://www.genome.jp/dbget-bin/www_bget?hsa:6573
KEGG_Orthology	KO:K14609	http://www.genome.jp/dbget-bin/www_bget?KO:K14609
KEGG_Pathway	ko04977	http://www.genome.jp/kegg-bin/show_pathway?ko04977
MIM	600424	http://www.ncbi.nlm.nih.gov/omim/600424
OMA	TSSIWLC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TSSIWLC
Orphanet	306574	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=306574
OrthoDB	EOG091G0BSJ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0BSJ
PANTHER	PTHR10686	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10686
PANTHER	PTHR10686:SF12	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10686:SF12
PSORT	swissprot:S19A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S19A1_HUMAN
PSORT-B	swissprot:S19A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S19A1_HUMAN
PSORT2	swissprot:S19A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S19A1_HUMAN
Pfam	PF01770	http://pfam.xfam.org/family/PF01770
PharmGKB	PA327	http://www.pharmgkb.org/do/serve?objId=PA327&objCls=Gene
Phobius	swissprot:S19A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S19A1_HUMAN
PhylomeDB	P41440	http://phylomedb.org/?seqid=P41440
ProteinModelPortal	P41440	http://www.proteinmodelportal.org/query/uniprot/P41440
PubMed	10347183	http://www.ncbi.nlm.nih.gov/pubmed/10347183
PubMed	10830953	http://www.ncbi.nlm.nih.gov/pubmed/10830953
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	7615551	http://www.ncbi.nlm.nih.gov/pubmed/7615551
PubMed	7641195	http://www.ncbi.nlm.nih.gov/pubmed/7641195
PubMed	7826387	http://www.ncbi.nlm.nih.gov/pubmed/7826387
PubMed	7852378	http://www.ncbi.nlm.nih.gov/pubmed/7852378
PubMed	9041240	http://www.ncbi.nlm.nih.gov/pubmed/9041240
Reactome	R-HSA-196757	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-196757
RefSeq	NP_001192135	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001192135
RefSeq	NP_001192136	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001192136
RefSeq	NP_919231	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_919231
RefSeq	XP_011528002	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011528002
RefSeq	XP_011528003	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011528003
RefSeq	XP_011528004	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011528004
RefSeq	XP_011528005	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011528005
RefSeq	XP_011528006	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011528006
RefSeq	XP_016883935	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016883935
STRING	9606.ENSP00000308895	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000308895&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.48.1	http://www.tcdb.org/search/result.php?tc=2.A.48.1
TIGRFAMs	TIGR00806	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00806
UCSC	uc002zhl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002zhl&org=rat
UniGene	Hs.736903	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.736903
UniGene	Hs.84190	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.84190
UniProtKB	S19A1_HUMAN	http://www.uniprot.org/uniprot/S19A1_HUMAN
UniProtKB-AC	P41440	http://www.uniprot.org/uniprot/P41440
charge	swissprot:S19A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S19A1_HUMAN
eggNOG	ENOG410XT34	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XT34
eggNOG	KOG3810	http://eggnogapi.embl.de/nog_data/html/tree/KOG3810
epestfind	swissprot:S19A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S19A1_HUMAN
garnier	swissprot:S19A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S19A1_HUMAN
helixturnhelix	swissprot:S19A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S19A1_HUMAN
hmoment	swissprot:S19A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S19A1_HUMAN
iep	swissprot:S19A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S19A1_HUMAN
inforesidue	swissprot:S19A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S19A1_HUMAN
neXtProt	NX_P41440	http://www.nextprot.org/db/entry/NX_P41440
octanol	swissprot:S19A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S19A1_HUMAN
pepcoil	swissprot:S19A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S19A1_HUMAN
pepdigest	swissprot:S19A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S19A1_HUMAN
pepinfo	swissprot:S19A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S19A1_HUMAN
pepnet	swissprot:S19A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S19A1_HUMAN
pepstats	swissprot:S19A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S19A1_HUMAN
pepwheel	swissprot:S19A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S19A1_HUMAN
pepwindow	swissprot:S19A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S19A1_HUMAN
sigcleave	swissprot:S19A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S19A1_HUMAN
## Database	ID	URL or Descriptions
# AltName	CUL5_HUMAN	Vasopressin-activated calcium-mobilizing receptor 1
# BioGrid	113743	444
# ChiTaRS	CUL5	human
# Ensembl	ENST00000393094	ENSP00000376808; ENSG00000166266
# Ensembl	ENST00000531427	ENSP00000435376; ENSG00000166266
# ExpressionAtlas	Q93034	baseline and differential
# FUNCTION	CUL5_HUMAN	Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor. 
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0031466	Cul5-RING ubiquitin ligase complex; IDA:UniProtKB.
# GO_function	GO:0004842	ubiquitin-protein transferase activity; TAS:Reactome.
# GO_function	GO:0004872	receptor activity; TAS:ProtInc.
# GO_function	GO:0005262	calcium channel activity; TAS:ProtInc.
# GO_function	GO:0031625	ubiquitin protein ligase binding; IDA:UniProtKB.
# GO_process	GO:0000082	G1/S transition of mitotic cell cycle; TAS:ProtInc.
# GO_process	GO:0007050	cell cycle arrest; TAS:ProtInc.
# GO_process	GO:0008283	cell proliferation; TAS:ProtInc.
# GO_process	GO:0008285	negative regulation of cell proliferation; TAS:ProtInc.
# GO_process	GO:0016032	viral process; IEA:UniProtKB-KW.
# GO_process	GO:0038128	ERBB2 signaling pathway; TAS:Reactome.
# GO_process	GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:GO_Central.
# GO_process	GO:0097193	intrinsic apoptotic signaling pathway; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005829	cytosol
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0008283	cell proliferation
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# Gene3D	1.10.10.10	-; 2.
# Genevisible	Q93034	HS
# HGNC	HGNC:2556	CUL5
# INTERACTION	CUL5_HUMAN	O95376 ARIH2; NbExp=12; IntAct=EBI-1057139, EBI-711158; Q96Q27 ASB2; NbExp=4; IntAct=EBI-1057139, EBI-2880677; O95273 CCNDBP1; NbExp=3; IntAct=EBI-1057139, EBI-748961; O41974 GAMMAHV.ORF73 (xeno); NbExp=2; IntAct=EBI-1057139, EBI-6933128; Q08379 GOLGA2; NbExp=3; IntAct=EBI-1057139, EBI-618309; P62877 RBX1; NbExp=3; IntAct=EBI-1057139, EBI-398523; Q9UBF6 RNF7; NbExp=6; IntAct=EBI-1057139, EBI-398632; P12504 vif (xeno); NbExp=5; IntAct=EBI-1057139, EBI-779991; 
# IntAct	Q93034	42
# InterPro	IPR001373	Cullin_N
# InterPro	IPR011991	WHTH_DNA-bd_dom
# InterPro	IPR016157	Cullin_CS
# InterPro	IPR016158	Cullin_homology
# InterPro	IPR016159	Cullin_repeat-like_dom
# InterPro	IPR019559	Cullin_neddylation_domain
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko03400	 DNA repair and recombination proteins
# KEGG_Brite	ko04121	 M00388  ECS complex
# KEGG_Brite	ko04121	 Ubiquitin system
# KEGG_Pathway	ko04120	Ubiquitin mediated proteolysis
# MIM	601741	gene
# Organism	CUL5_HUMAN	Homo sapiens (Human)
# PATHWAY	CUL5_HUMAN	Protein modification; protein ubiquitination. 
# PDB	3DPL	X-ray; 2.60 A; C=401-780
# PDB	3DQV	X-ray; 3.00 A; C/D=401-780
# PDB	4JGH	X-ray; 3.00 A; D=10-386
# PDB	4N9F	X-ray; 3.30 A; 3/9/C/I/O/U/V/f/l/r/w/x=12-321
# PROSITE	PS01256	CULLIN_1
# PROSITE	PS50069	CULLIN_2
# PTM	CUL5_HUMAN	Neddylated; which enhances the ubiquitination activity of SCF and prevents binding of the inhibitor CAND1. Deneddylated via its interaction with the COP9 signalosome (CSN). {ECO 0000269|PubMed 10597293, ECO 0000269|PubMed 12186903, ECO 0000269|PubMed 18805092, ECO 0000269|PubMed 24076655}. 
# Pfam	PF00888	Cullin
# Pfam	PF10557	Cullin_Nedd8
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-180585	Vif-mediated degradation of APOBEC3G
# Reactome	R-HSA-8863795	Downregulation of ERBB2 signaling
# Reactome	R-HSA-983168:Antigen processing	 Ubiquitination & Proteasome degradation
# RecName	CUL5_HUMAN	Cullin-5
# RefSeq	NP_003469	NM_003478.3
# SIMILARITY	Belongs to the cullin family. {ECO:0000255|PROSITE- ProRule	PRU00330}.
# SMART	SM00182	CULLIN
# SMART	SM00884	Cullin_Nedd8
# SUBUNIT	(Microbial infection) The substrate recognition component can also be a viral protein such as HIV Vif, or human adenovirus 5 E1B large T-antigen and E4-orf6. {ECO:0000269|PubMed	12186903}. 
# SUBUNIT	CUL5_HUMAN	Component of multiple ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes formed of CUL5, Elongin BC (TCEB1 and TCEB2), RBX2 and a variable SOCS box domain- containing protein as substrate-specific recognition component. Component of the probable ECS(LRRC41) complex with the substrate recognition component LRRC41. Component of the probable ECS(SOCS1) complex with the substrate recognition component SOCS1. Component of the probable ECS(WSB1) complex with the substrate recognition subunit WSB1. Component of the probable ECS(SOCS3) complex with the substrate recognition component SOCS3. Component of the probable ECS(SPSB1) complex with the substrate recognition component SPSB1. Component of the probable ECS(SPSB2) complex with the substrate recognition component SPSB2. Component of the probable ECS(SPSB4) complex with the substrate recognition component SPSB4. Component of the probable ECS(RAB40C) complex with the substrate recognition subunit RAB40C. May also form complexes containing CUL5, elongin BC complex (TCEB1 and TCEB2), RBX1 and TCEB3. May also form complexes containing CUL5, Elongin BC (TCEB1 and TCEB2), RBX1 and VHL. Interacts with RNF7/RBX2, LRRC41, SOCS3, SPSB1, SPSB2, SPSB4 and RAB40C. Interacts with ASB1, ASB2, ASB6, ASB7 and ASB12. Interacts (when neddylated) with ARIH2; leading to activate the E3 ligase activity of ARIH1 (PubMed 24076655). {ECO 0000269|PubMed 10230407, ECO 0000269|PubMed 11384984, ECO 0000269|PubMed 15574592, ECO 0000269|PubMed 15601820, ECO 0000269|PubMed 16325183, ECO 0000269|PubMed 18805092, ECO 0000269|PubMed 24076655}. 
# SUPFAM	SSF46785	SSF46785
# SUPFAM	SSF74788	SSF74788
# SUPFAM	SSF75632	SSF75632
# UCSC	uc001pjv	human
# eggNOG	COG5647	LUCA
# eggNOG	KOG2285	Eukaryota
BLAST	swissprot:CUL5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CUL5_HUMAN
BioCyc	ZFISH:ENSG00000166266-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000166266-MONOMER
COXPRESdb	8065	http://coxpresdb.jp/data/gene/8065.shtml
CleanEx	HS_CUL5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CUL5
DIP	DIP-43696N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-43696N
DOI	10.1016/S1097-2765(00)80482-7	http://dx.doi.org/10.1016/S1097-2765(00)80482-7
DOI	10.1016/j.cell.2008.07.022	http://dx.doi.org/10.1016/j.cell.2008.07.022
DOI	10.1016/j.febslet.2005.11.016	http://dx.doi.org/10.1016/j.febslet.2005.11.016
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/emboj.2013.209	http://dx.doi.org/10.1038/emboj.2013.209
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.onc.1203093	http://dx.doi.org/10.1038/sj.onc.1203093
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/jbc.M103093200	http://dx.doi.org/10.1074/jbc.M103093200
DOI	10.1101/gad.1249904	http://dx.doi.org/10.1101/gad.1249904
DOI	10.1101/gad.1252404	http://dx.doi.org/10.1101/gad.1252404
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1101/gr.7.1.71	http://dx.doi.org/10.1101/gr.7.1.71
DOI	10.1128/JVI.76.18.9194-9206.2002	http://dx.doi.org/10.1128/JVI.76.18.9194-9206.2002
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF017061	http://www.ebi.ac.uk/ena/data/view/AF017061
EMBL	AF327710	http://www.ebi.ac.uk/ena/data/view/AF327710
EMBL	AK292575	http://www.ebi.ac.uk/ena/data/view/AK292575
EMBL	BC063306	http://www.ebi.ac.uk/ena/data/view/BC063306
EMBL	CH471065	http://www.ebi.ac.uk/ena/data/view/CH471065
EMBL	X81882	http://www.ebi.ac.uk/ena/data/view/X81882
Ensembl	ENST00000393094	http://www.ensembl.org/id/ENST00000393094
Ensembl	ENST00000531427	http://www.ensembl.org/id/ENST00000531427
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0031466	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031466
GO_function	GO:0004842	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004842
GO_function	GO:0004872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004872
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0031625	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031625
GO_process	GO:0000082	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000082
GO_process	GO:0007050	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007050
GO_process	GO:0008283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008283
GO_process	GO:0008285	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008285
GO_process	GO:0016032	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016032
GO_process	GO:0038128	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0038128
GO_process	GO:0042787	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042787
GO_process	GO:0097193	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097193
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0008283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008283
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
Gene3D	1.10.10.10	http://www.cathdb.info/version/latest/superfamily/1.10.10.10
GeneCards	CUL5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CUL5
GeneID	8065	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8065
GeneTree	ENSGT00760000119212	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119212
HGNC	HGNC:2556	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2556
HOGENOM	HOG000007610	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007610&db=HOGENOM6
HOVERGEN	HBG099672	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG099672&db=HOVERGEN
HPA	CAB017787	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB017787
HPA	HPA002185	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA002185
InParanoid	Q93034	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q93034
IntAct	Q93034	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q93034*
InterPro	IPR001373	http://www.ebi.ac.uk/interpro/entry/IPR001373
InterPro	IPR011991	http://www.ebi.ac.uk/interpro/entry/IPR011991
InterPro	IPR016157	http://www.ebi.ac.uk/interpro/entry/IPR016157
InterPro	IPR016158	http://www.ebi.ac.uk/interpro/entry/IPR016158
InterPro	IPR016159	http://www.ebi.ac.uk/interpro/entry/IPR016159
InterPro	IPR019559	http://www.ebi.ac.uk/interpro/entry/IPR019559
Jabion	8065	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=8065
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko03400	http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Brite	ko04121	http://www.genome.jp/dbget-bin/www_bget?ko04121
KEGG_Brite	ko04121	http://www.genome.jp/dbget-bin/www_bget?ko04121
KEGG_Gene	hsa:8065	http://www.genome.jp/dbget-bin/www_bget?hsa:8065
KEGG_Orthology	KO:K10612	http://www.genome.jp/dbget-bin/www_bget?KO:K10612
KEGG_Pathway	ko04120	http://www.genome.jp/kegg-bin/show_pathway?ko04120
MIM	601741	http://www.ncbi.nlm.nih.gov/omim/601741
MINT	MINT-1184052	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1184052
OMA	NQEFAIV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NQEFAIV
OrthoDB	EOG091G02MQ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02MQ
PDB	3DPL	http://www.ebi.ac.uk/pdbe-srv/view/entry/3DPL
PDB	3DQV	http://www.ebi.ac.uk/pdbe-srv/view/entry/3DQV
PDB	4JGH	http://www.ebi.ac.uk/pdbe-srv/view/entry/4JGH
PDB	4N9F	http://www.ebi.ac.uk/pdbe-srv/view/entry/4N9F
PDBsum	3DPL	http://www.ebi.ac.uk/pdbsum/3DPL
PDBsum	3DQV	http://www.ebi.ac.uk/pdbsum/3DQV
PDBsum	4JGH	http://www.ebi.ac.uk/pdbsum/4JGH
PDBsum	4N9F	http://www.ebi.ac.uk/pdbsum/4N9F
PROSITE	PS01256	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01256
PROSITE	PS50069	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50069
PSORT	swissprot:CUL5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CUL5_HUMAN
PSORT-B	swissprot:CUL5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CUL5_HUMAN
PSORT2	swissprot:CUL5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CUL5_HUMAN
Pfam	PF00888	http://pfam.xfam.org/family/PF00888
Pfam	PF10557	http://pfam.xfam.org/family/PF10557
PharmGKB	PA27052	http://www.pharmgkb.org/do/serve?objId=PA27052&objCls=Gene
Phobius	swissprot:CUL5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CUL5_HUMAN
PhylomeDB	Q93034	http://phylomedb.org/?seqid=Q93034
ProteinModelPortal	Q93034	http://www.proteinmodelportal.org/query/uniprot/Q93034
PubMed	10230407	http://www.ncbi.nlm.nih.gov/pubmed/10230407
PubMed	10597293	http://www.ncbi.nlm.nih.gov/pubmed/10597293
PubMed	11384984	http://www.ncbi.nlm.nih.gov/pubmed/11384984
PubMed	12186903	http://www.ncbi.nlm.nih.gov/pubmed/12186903
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15574592	http://www.ncbi.nlm.nih.gov/pubmed/15574592
PubMed	15601820	http://www.ncbi.nlm.nih.gov/pubmed/15601820
PubMed	16325183	http://www.ncbi.nlm.nih.gov/pubmed/16325183
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18805092	http://www.ncbi.nlm.nih.gov/pubmed/18805092
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24076655	http://www.ncbi.nlm.nih.gov/pubmed/24076655
PubMed	9037604	http://www.ncbi.nlm.nih.gov/pubmed/9037604
Reactome	R-HSA-180585	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-180585
Reactome	R-HSA-8863795	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8863795
Reactome	R-HSA-983168	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983168
RefSeq	NP_003469	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003469
SMART	SM00182	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00182
SMART	SM00884	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00884
SMR	Q93034	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q93034
STRING	9606.ENSP00000376808	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000376808&targetmode=cogs
SUPFAM	SSF46785	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785
SUPFAM	SSF74788	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF74788
SUPFAM	SSF75632	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF75632
UCSC	uc001pjv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001pjv&org=rat
UniGene	Hs.440320	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.440320
UniProtKB	CUL5_HUMAN	http://www.uniprot.org/uniprot/CUL5_HUMAN
UniProtKB-AC	Q93034	http://www.uniprot.org/uniprot/Q93034
charge	swissprot:CUL5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CUL5_HUMAN
eggNOG	COG5647	http://eggnogapi.embl.de/nog_data/html/tree/COG5647
eggNOG	KOG2285	http://eggnogapi.embl.de/nog_data/html/tree/KOG2285
epestfind	swissprot:CUL5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CUL5_HUMAN
garnier	swissprot:CUL5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CUL5_HUMAN
helixturnhelix	swissprot:CUL5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CUL5_HUMAN
hmoment	swissprot:CUL5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CUL5_HUMAN
iep	swissprot:CUL5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CUL5_HUMAN
inforesidue	swissprot:CUL5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CUL5_HUMAN
neXtProt	NX_Q93034	http://www.nextprot.org/db/entry/NX_Q93034
octanol	swissprot:CUL5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CUL5_HUMAN
pepcoil	swissprot:CUL5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CUL5_HUMAN
pepdigest	swissprot:CUL5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CUL5_HUMAN
pepinfo	swissprot:CUL5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CUL5_HUMAN
pepnet	swissprot:CUL5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CUL5_HUMAN
pepstats	swissprot:CUL5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CUL5_HUMAN
pepwheel	swissprot:CUL5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CUL5_HUMAN
pepwindow	swissprot:CUL5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CUL5_HUMAN
sigcleave	swissprot:CUL5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CUL5_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	PLP2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q04941-1; Sequence=Displayed; Name=2; IsoId=Q04941-2; Sequence=VSP_041602; 
# AltName	PLP2_HUMAN	Differentiation-dependent protein A4
# AltName	PLP2_HUMAN	Intestinal membrane A4 protein
# BioGrid	111369	27
# CCDS	CCDS14319	-. [Q04941-1]
# ChiTaRS	PLP2	human
# Ensembl	ENST00000376322	ENSP00000365500; ENSG00000102007. [Q04941-2]
# Ensembl	ENST00000376327	ENSP00000365505; ENSG00000102007. [Q04941-1]
# ExpressionAtlas	Q04941	baseline and differential
# FUNCTION	PLP2_HUMAN	May play a role in cell differentiation in the intestinal epithelium. 
# GO_component	GO:0005783	endoplasmic reticulum; TAS:ProtInc.
# GO_component	GO:0005789	endoplasmic reticulum membrane; TAS:ProtInc.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0015075	ion transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0019956	chemokine binding; IPI:UniProtKB.
# GO_process	GO:0006811	ion transport; TAS:ProtInc.
# GO_process	GO:0006935	chemotaxis; NAS:UniProtKB.
# GO_process	GO:0019221	cytokine-mediated signaling pathway; NAS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0040011	locomotion
# Genevisible	Q04941	HS
# HGNC	HGNC:9087	PLP2
# INTERACTION	PLP2_HUMAN	Q8N6L0 CCDC155; NbExp=3; IntAct=EBI-608347, EBI-749265; P32246 CCR1; NbExp=3; IntAct=EBI-608347, EBI-608322; Q9BSE2 TMEM79; NbExp=3; IntAct=EBI-608347, EBI-8649725; 
# IntAct	Q04941	10
# InterPro	IPR008253	Marvel
# MIM	300112	gene
# Organism	PLP2_HUMAN	Homo sapiens (Human)
# PIR	S32567	S32567
# PROSITE	PS51225	MARVEL
# Pfam	PF01284	MARVEL
# Proteomes	UP000005640	Chromosome X
# RecName	PLP2_HUMAN	Proteolipid protein 2
# RefSeq	NP_002659	NM_002668.2. [Q04941-1]
# SIMILARITY	Contains 1 MARVEL domain. {ECO:0000255|PROSITE- ProRule	PRU00581}.
# SUBCELLULAR LOCATION	PLP2_HUMAN	Membrane; Multi-pass membrane protein. 
# TCDB	1.A.64.5	the plasmolipin (plasmolipin) family
# TISSUE SPECIFICITY	PLP2_HUMAN	Enriched in colonic mucosa. The expression of A4 follows a gradient along the crypto-villus axis with the most abundant message occurring in the lower half of the crypt. 
# TopDownProteomics	Q04941-1	-. [Q04941-1]
# UCSC	uc004dmx	human. [Q04941-1]
# eggNOG	ENOG4111IAF	LUCA
# eggNOG	KOG4788	Eukaryota
BLAST	swissprot:PLP2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:PLP2_HUMAN
BioCyc	ZFISH:ENSG00000102007-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000102007-MONOMER
COXPRESdb	5355	http://coxpresdb.jp/data/gene/5355.shtml
CleanEx	HS_PLP2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_PLP2
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/abbi.1993.1197	http://dx.doi.org/10.1006/abbi.1993.1197
DOI	10.1006/geno.1997.4941	http://dx.doi.org/10.1006/geno.1997.4941
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1101/gr.4039406	http://dx.doi.org/10.1101/gr.4039406
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF196779	http://www.ebi.ac.uk/ena/data/view/AF196779
EMBL	BC109066	http://www.ebi.ac.uk/ena/data/view/BC109066
EMBL	DB102321	http://www.ebi.ac.uk/ena/data/view/DB102321
EMBL	L09604	http://www.ebi.ac.uk/ena/data/view/L09604
EMBL	U93305	http://www.ebi.ac.uk/ena/data/view/U93305
Ensembl	ENST00000376322	http://www.ensembl.org/id/ENST00000376322
Ensembl	ENST00000376327	http://www.ensembl.org/id/ENST00000376327
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0015075	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015075
GO_function	GO:0019956	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019956
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006935	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006935
GO_process	GO:0019221	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019221
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0040011	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011
GeneCards	PLP2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=PLP2
GeneID	5355	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5355
GeneTree	ENSGT00530000063326	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063326
HGNC	HGNC:9087	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:9087
HOGENOM	HOG000293179	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000293179&db=HOGENOM6
HOVERGEN	HBG099247	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG099247&db=HOVERGEN
HPA	HPA042415	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042415
InParanoid	Q04941	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q04941
IntAct	Q04941	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q04941*
InterPro	IPR008253	http://www.ebi.ac.uk/interpro/entry/IPR008253
Jabion	5355	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=5355
KEGG_Gene	hsa:5355	http://www.genome.jp/dbget-bin/www_bget?hsa:5355
MIM	300112	http://www.ncbi.nlm.nih.gov/omim/300112
MINT	MINT-1394473	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1394473
OMA	IYMCDLH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IYMCDLH
OrthoDB	EOG091G0SSY	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0SSY
PROSITE	PS51225	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51225
PSORT	swissprot:PLP2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:PLP2_HUMAN
PSORT-B	swissprot:PLP2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:PLP2_HUMAN
PSORT2	swissprot:PLP2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:PLP2_HUMAN
Pfam	PF01284	http://pfam.xfam.org/family/PF01284
PharmGKB	PA33415	http://www.pharmgkb.org/do/serve?objId=PA33415&objCls=Gene
Phobius	swissprot:PLP2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:PLP2_HUMAN
PhylomeDB	Q04941	http://phylomedb.org/?seqid=Q04941
ProteinModelPortal	Q04941	http://www.proteinmodelportal.org/query/uniprot/Q04941
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	16344560	http://www.ncbi.nlm.nih.gov/pubmed/16344560
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	8470895	http://www.ncbi.nlm.nih.gov/pubmed/8470895
PubMed	9344658	http://www.ncbi.nlm.nih.gov/pubmed/9344658
RefSeq	NP_002659	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002659
STRING	9606.ENSP00000365505	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000365505&targetmode=cogs
TCDB	1.A.64.5	http://www.tcdb.org/search/result.php?tc=1.A.64.5
UCSC	uc004dmx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004dmx&org=rat
UniGene	Hs.77422	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.77422
UniProtKB	PLP2_HUMAN	http://www.uniprot.org/uniprot/PLP2_HUMAN
UniProtKB-AC	Q04941	http://www.uniprot.org/uniprot/Q04941
charge	swissprot:PLP2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:PLP2_HUMAN
eggNOG	ENOG4111IAF	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111IAF
eggNOG	KOG4788	http://eggnogapi.embl.de/nog_data/html/tree/KOG4788
epestfind	swissprot:PLP2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:PLP2_HUMAN
garnier	swissprot:PLP2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:PLP2_HUMAN
helixturnhelix	swissprot:PLP2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:PLP2_HUMAN
hmoment	swissprot:PLP2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:PLP2_HUMAN
iep	swissprot:PLP2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:PLP2_HUMAN
inforesidue	swissprot:PLP2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:PLP2_HUMAN
neXtProt	NX_Q04941	http://www.nextprot.org/db/entry/NX_Q04941
octanol	swissprot:PLP2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:PLP2_HUMAN
pepcoil	swissprot:PLP2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:PLP2_HUMAN
pepdigest	swissprot:PLP2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:PLP2_HUMAN
pepinfo	swissprot:PLP2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:PLP2_HUMAN
pepnet	swissprot:PLP2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:PLP2_HUMAN
pepstats	swissprot:PLP2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:PLP2_HUMAN
pepwheel	swissprot:PLP2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:PLP2_HUMAN
pepwindow	swissprot:PLP2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:PLP2_HUMAN
sigcleave	swissprot:PLP2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:PLP2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ATNG_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=A; IsoId=P54710-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=P54710-2; Sequence=VSP_001580; 
# AltName	ATNG_HUMAN	FXYD domain-containing ion transport regulator 2
# AltName	ATNG_HUMAN	Sodium pump gamma chain
# CCDS	CCDS8385	-. [P54710-2]
# CCDS	CCDS8386	-. [P54710-1]
# ChiTaRS	FXYD2	human
# DISEASE	ATNG_HUMAN	Hypomagnesemia 2 (HOMG2) [MIM 154020]  A disorder due to primary renal wasting of magnesium. Plasma levels of other electrolytes are normal. The only abnormality found, in addition to low magnesium levels, is lowered renal excretion of calcium resulting in hypocalciuria. {ECO 0000269|PubMed 11062458}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00606	Cyclothiazide
# Ensembl	ENST00000260287	ENSP00000260287; ENSG00000137731. [P54710-2]
# Ensembl	ENST00000292079	ENSP00000292079; ENSG00000137731. [P54710-1]
# Ensembl	ENST00000528014	ENSP00000432430; ENSG00000137731. [P54710-2]
# Ensembl	ENST00000532119	ENSP00000436414; ENSG00000137731. [P54710-2]
# FUNCTION	ATNG_HUMAN	May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase. 
# GO_component	ATNG_HUMAN	GO 0005890 sodium potassium-exchanging ATPase complex; ISS BHF-UCL.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	ATNG_HUMAN	GO 0005391 sodium potassium-exchanging ATPase activity; TAS ProtInc.
# GO_function	GO:0005215	transporter activity; TAS:ProtInc.
# GO_function	GO:0005216	ion channel activity; IEA:InterPro.
# GO_function	GO:0017080	sodium channel regulator activity; IBA:GO_Central.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0036376	sodium ion export from cell; ISS:BHF-UCL.
# GO_process	GO:0090662	ATP hydrolysis coupled transmembrane transport; ISS:BHF-UCL.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GO_process	GO:1990573	potassium ion import across plasma membrane; ISS:BHF-UCL.
# GO_process	GO:2000649	regulation of sodium ion transmembrane transporter activity; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P54710	HS
# HGNC	HGNC:4026	FXYD2
# InterPro	IPR000272	Ion-transport_regulator_FXYD
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Disease	H01210	[Inherited metabolic disease] Hypomagnesemia
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko04960	Aldosterone-regulated sodium reabsorption
# KEGG_Pathway	ko04961	Endocrine and other factor-regulated calcium reabsorption
# KEGG_Pathway	ko04964	Proximal tubule bicarbonate reclamation
# KEGG_Pathway	ko04970	Salivary secretion
# KEGG_Pathway	ko04972	Pancreatic secretion
# KEGG_Pathway	ko04973	Carbohydrate digestion and absorption
# KEGG_Pathway	ko04974	Protein digestion and absorption
# KEGG_Pathway	ko04976	Bile secretion
# KEGG_Pathway	ko04978	Mineral absorption
# MIM	154020	phenotype
# MIM	601814	gene
# Organism	ATNG_HUMAN	Homo sapiens (Human)
# Orphanet	34528	Autosomal dominant primary hypomagnesemia with hypocalciuria
# PDB	2MKV	NMR; -; A=9-66
# PIR	S54159	S54159
# PROSITE	PS01310	FXYD
# Pfam	PF02038	ATP1G1_PLM_MAT8
# ProDom	PD005989	PD005989
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-5578775	Ion homeostasis
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	ATNG_HUMAN	Sodium/potassium-transporting ATPase subunit gamma
# RefSeq	NP_001671	NM_001680.4. [P54710-1]
# RefSeq	NP_067614	NM_021603.3. [P54710-2]
# SEQUENCE CAUTION	Sequence=AAB09425.1; Type=Frameshift; Positions=12; Evidence={ECO:0000305}; Sequence=CAA60152.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the FXYD family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	ATNG_HUMAN	Membrane {ECO 0000305}; Single-pass type III membrane protein {ECO 0000305}. 
# SUBUNIT	Composed of three subunits	 alpha (catalytic), beta and gamma. 
# TCDB	1.A.27.2	the phospholemman (plm) family
# TISSUE SPECIFICITY	ATNG_HUMAN	Expressed in the distal convoluted tubule in the kidney. Found on basolateral membranes of nephron epithelial cells. 
# UCSC	uc001prj	human. [P54710-1]
# eggNOG	ENOG410J35I	Eukaryota
# eggNOG	ENOG410Z10F	LUCA
BLAST	swissprot:ATNG_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ATNG_HUMAN
BioCyc	ZFISH:HS06384-MONOMER	http://biocyc.org/getid?id=ZFISH:HS06384-MONOMER
COXPRESdb	486	http://coxpresdb.jp/data/gene/486.shtml
CleanEx	HS_FXYD2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_FXYD2
DOI	10.1006/bbrc.2000.3907	http://dx.doi.org/10.1006/bbrc.2000.3907
DOI	10.1016/S0167-4781(96)00219-9	http://dx.doi.org/10.1016/S0167-4781(96)00219-9
DOI	10.1038/81543	http://dx.doi.org/10.1038/81543
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00606	http://www.drugbank.ca/drugs/DB00606
EMBL	AF241235	http://www.ebi.ac.uk/ena/data/view/AF241235
EMBL	AF241235	http://www.ebi.ac.uk/ena/data/view/AF241235
EMBL	AF241236	http://www.ebi.ac.uk/ena/data/view/AF241236
EMBL	AF316896	http://www.ebi.ac.uk/ena/data/view/AF316896
EMBL	AF316896	http://www.ebi.ac.uk/ena/data/view/AF316896
EMBL	BC005302	http://www.ebi.ac.uk/ena/data/view/BC005302
EMBL	BC013289	http://www.ebi.ac.uk/ena/data/view/BC013289
EMBL	BT006721	http://www.ebi.ac.uk/ena/data/view/BT006721
EMBL	U50743	http://www.ebi.ac.uk/ena/data/view/U50743
EMBL	X86400	http://www.ebi.ac.uk/ena/data/view/X86400
Ensembl	ENST00000260287	http://www.ensembl.org/id/ENST00000260287
Ensembl	ENST00000292079	http://www.ensembl.org/id/ENST00000292079
Ensembl	ENST00000528014	http://www.ensembl.org/id/ENST00000528014
Ensembl	ENST00000532119	http://www.ensembl.org/id/ENST00000532119
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005890
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0005216	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005216
GO_function	GO:0005391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005391
GO_function	GO:0017080	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017080
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0036376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036376
GO_process	GO:0090662	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090662
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GO_process	GO:1990573	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990573
GO_process	GO:2000649	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000649
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	FXYD2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=FXYD2
GeneID	486	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=486
GeneTree	ENSGT00530000063932	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063932
HGNC	HGNC:4026	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4026
HOGENOM	HOG000234468	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234468&db=HOGENOM6
HOVERGEN	HBG100880	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG100880&db=HOVERGEN
HPA	CAB004649	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB004649
HPA	HPA068838	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA068838
InParanoid	P54710	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P54710
InterPro	IPR000272	http://www.ebi.ac.uk/interpro/entry/IPR000272
Jabion	486	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=486
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Disease	H01210	http://www.genome.jp/dbget-bin/www_bget?H01210
KEGG_Gene	hsa:486	http://www.genome.jp/dbget-bin/www_bget?hsa:486
KEGG_Orthology	KO:K01538	http://www.genome.jp/dbget-bin/www_bget?KO:K01538
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko04960	http://www.genome.jp/kegg-bin/show_pathway?ko04960
KEGG_Pathway	ko04961	http://www.genome.jp/kegg-bin/show_pathway?ko04961
KEGG_Pathway	ko04964	http://www.genome.jp/kegg-bin/show_pathway?ko04964
KEGG_Pathway	ko04970	http://www.genome.jp/kegg-bin/show_pathway?ko04970
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
KEGG_Pathway	ko04973	http://www.genome.jp/kegg-bin/show_pathway?ko04973
KEGG_Pathway	ko04974	http://www.genome.jp/kegg-bin/show_pathway?ko04974
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
KEGG_Pathway	ko04978	http://www.genome.jp/kegg-bin/show_pathway?ko04978
MIM	154020	http://www.ncbi.nlm.nih.gov/omim/154020
MIM	601814	http://www.ncbi.nlm.nih.gov/omim/601814
OMA	DRWYLGG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DRWYLGG
Orphanet	34528	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=34528
OrthoDB	EOG091G13K5	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G13K5
PDB	2MKV	http://www.ebi.ac.uk/pdbe-srv/view/entry/2MKV
PDBsum	2MKV	http://www.ebi.ac.uk/pdbsum/2MKV
PROSITE	PS01310	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01310
PSORT	swissprot:ATNG_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ATNG_HUMAN
PSORT-B	swissprot:ATNG_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ATNG_HUMAN
PSORT2	swissprot:ATNG_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ATNG_HUMAN
Pfam	PF02038	http://pfam.xfam.org/family/PF02038
PharmGKB	PA28442	http://www.pharmgkb.org/do/serve?objId=PA28442&objCls=Gene
Phobius	swissprot:ATNG_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ATNG_HUMAN
PhylomeDB	P54710	http://phylomedb.org/?seqid=P54710
ProteinModelPortal	P54710	http://www.proteinmodelportal.org/query/uniprot/P54710
PubMed	11062458	http://www.ncbi.nlm.nih.gov/pubmed/11062458
PubMed	11112438	http://www.ncbi.nlm.nih.gov/pubmed/11112438
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	9048881	http://www.ncbi.nlm.nih.gov/pubmed/9048881
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_001671	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001671
RefSeq	NP_067614	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_067614
SMR	P54710	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P54710
STRING	9606.ENSP00000292079	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000292079&targetmode=cogs
TCDB	1.A.27.2	http://www.tcdb.org/search/result.php?tc=1.A.27.2
UCSC	uc001prj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001prj&org=rat
UniGene	Hs.731865	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.731865
UniProtKB	ATNG_HUMAN	http://www.uniprot.org/uniprot/ATNG_HUMAN
UniProtKB-AC	P54710	http://www.uniprot.org/uniprot/P54710
charge	swissprot:ATNG_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ATNG_HUMAN
eggNOG	ENOG410J35I	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410J35I
eggNOG	ENOG410Z10F	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z10F
epestfind	swissprot:ATNG_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ATNG_HUMAN
garnier	swissprot:ATNG_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ATNG_HUMAN
helixturnhelix	swissprot:ATNG_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATNG_HUMAN
hmoment	swissprot:ATNG_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ATNG_HUMAN
iep	swissprot:ATNG_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ATNG_HUMAN
inforesidue	swissprot:ATNG_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ATNG_HUMAN
neXtProt	NX_P54710	http://www.nextprot.org/db/entry/NX_P54710
octanol	swissprot:ATNG_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ATNG_HUMAN
pepcoil	swissprot:ATNG_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ATNG_HUMAN
pepdigest	swissprot:ATNG_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ATNG_HUMAN
pepinfo	swissprot:ATNG_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ATNG_HUMAN
pepnet	swissprot:ATNG_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ATNG_HUMAN
pepstats	swissprot:ATNG_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ATNG_HUMAN
pepwheel	swissprot:ATNG_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ATNG_HUMAN
pepwindow	swissprot:ATNG_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ATNG_HUMAN
sigcleave	swissprot:ATNG_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ATNG_HUMAN
## Database	ID	URL or Descriptions
# AltName	SO4C1_HUMAN	OATP-H
# AltName	SO4C1_HUMAN	Organic anion transporter M1
# AltName	SO4C1_HUMAN	Solute carrier family 21 member 20
# BIOPHYSICOCHEMICAL PROPERTIES	SO4C1_HUMAN	Kinetic parameters  KM=7.8 uM for digoxin {ECO 0000269|PubMed 14993604}; KM=0.38 uM for ouabain {ECO 0000269|PubMed 14993604}; KM=5.9 uM for thyroxine {ECO 0000269|PubMed 14993604}; 
# BioGrid	131662	2
# CDD	cd06174	MFS
# DrugBank	DB00279	Liothyronine
# DrugBank	DB00390	Digoxin
# DrugBank	DB00451	Levothyroxine
# DrugBank	DB00509	Dextrothyroxine
# DrugBank	DB00563	Methotrexate
# DrugBank	DB01092	Ouabain
# DrugBank	DB01396	Digitoxin
# DrugBank	DB01583	Liotrix
# DrugBank	DB06335	Saxagliptin
# Ensembl	ENST00000310954	ENSP00000309741; ENSG00000173930
# FUNCTION	SO4C1_HUMAN	Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion- transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg. {ECO 0000250|UniProtKB Q8BGD4, ECO 0000269|PubMed 14993604, ECO 0000269|PubMed 17314201}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0015347	sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0007275	multicellular organism development; IEA:UniProtKB-KW.
# GO_process	GO:0007283	spermatogenesis; IEA:UniProtKB-KW.
# GO_process	GO:0030154	cell differentiation; IEA:UniProtKB-KW.
# GO_process	GO:0043252	sodium-independent organic anion transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0048856	anatomical structure development
# Genevisible	Q6ZQN7	HS
# HGNC	HGNC:23612	SLCO4C1
# InterPro	IPR002350	Kazal_dom
# InterPro	IPR004156	OA_transporter
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02001	Solute carrier family
# MIM	609013	gene
# MISCELLANEOUS	SLCO4C1-mediated digoxin uptake is inhibited by digoxin itself and related compounds such as ouabain, digitoxin and digoxigenin. {ECO:0000269|PubMed	14993604}. 
# Organism	SO4C1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11388	PTHR11388
# PROSITE	PS50850	MFS
# PROSITE	PS51465	KAZAL_2
# Pfam	PF03137	OATP
# Pfam	PF07648	Kazal_2
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-6798695	Neutrophil degranulation
# Reactome	R-HSA-879518	Transport of organic anions
# RecName	SO4C1_HUMAN	Solute carrier organic anion transporter family member 4C1
# RefSeq	NP_851322	NM_180991.4
# SIMILARITY	Belongs to the organo anion transporter (TC 2.A.60) family. {ECO	0000255}. 
# SIMILARITY	Contains 1 Kazal-like domain. {ECO:0000255|PROSITE- ProRule	PRU00798}.
# SUBCELLULAR LOCATION	SO4C1_HUMAN	Basolateral cell membrane {ECO 0000250|UniProtKB Q71MB6}; Multi-pass membrane protein {ECO 0000250|UniProtKB Q71MB6}. Note=Detected at the basolateral membrane of the proximal tubule cell in the kidney. {ECO 0000250|UniProtKB Q71MB6}. 
# SUPFAM	SSF103473	SSF103473; 3
# TCDB	2.A.60.1.11	the organo anion transporter (oat) family
# TIGRFAMs	TIGR00805	oat
# TISSUE SPECIFICITY	Predominantly expressed in kidney but also weakly expressed in both fetal liver and kidney. {ECO:0000269|PubMed	14993604}. 
# UCSC	uc003knm	human
# eggNOG	ENOG410XRSF	LUCA
# eggNOG	KOG3626	Eukaryota
BLAST	swissprot:SO4C1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SO4C1_HUMAN
COXPRESdb	353189	http://coxpresdb.jp/data/gene/353189.shtml
CleanEx	HS_SLCO4C1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLCO4C1
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0304987101	http://dx.doi.org/10.1073/pnas.0304987101
DOI	10.1124/jpet.106.116517	http://dx.doi.org/10.1124/jpet.106.116517
DrugBank	DB00279	http://www.drugbank.ca/drugs/DB00279
DrugBank	DB00390	http://www.drugbank.ca/drugs/DB00390
DrugBank	DB00451	http://www.drugbank.ca/drugs/DB00451
DrugBank	DB00509	http://www.drugbank.ca/drugs/DB00509
DrugBank	DB00563	http://www.drugbank.ca/drugs/DB00563
DrugBank	DB01092	http://www.drugbank.ca/drugs/DB01092
DrugBank	DB01396	http://www.drugbank.ca/drugs/DB01396
DrugBank	DB01583	http://www.drugbank.ca/drugs/DB01583
DrugBank	DB06335	http://www.drugbank.ca/drugs/DB06335
EMBL	AF401643	http://www.ebi.ac.uk/ena/data/view/AF401643
EMBL	AK128854	http://www.ebi.ac.uk/ena/data/view/AK128854
EMBL	AY273896	http://www.ebi.ac.uk/ena/data/view/AY273896
EMBL	CH471086	http://www.ebi.ac.uk/ena/data/view/CH471086
Ensembl	ENST00000310954	http://www.ensembl.org/id/ENST00000310954
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0015347	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015347
GO_process	GO:0007275	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007275
GO_process	GO:0007283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007283
GO_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GO_process	GO:0043252	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043252
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GeneCards	SLCO4C1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLCO4C1
GeneID	353189	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=353189
GeneTree	ENSGT00760000119014	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119014
H-InvDB	HIX0024798	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0024798
HGNC	HGNC:23612	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:23612
HOGENOM	HOG000231270	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231270&db=HOGENOM6
HOVERGEN	HBG100565	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG100565&db=HOVERGEN
HPA	HPA036516	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA036516
InParanoid	Q6ZQN7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6ZQN7
IntAct	Q6ZQN7	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q6ZQN7*
InterPro	IPR002350	http://www.ebi.ac.uk/interpro/entry/IPR002350
InterPro	IPR004156	http://www.ebi.ac.uk/interpro/entry/IPR004156
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	353189	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=353189
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:353189	http://www.genome.jp/dbget-bin/www_bget?hsa:353189
KEGG_Orthology	KO:K14355	http://www.genome.jp/dbget-bin/www_bget?KO:K14355
MIM	609013	http://www.ncbi.nlm.nih.gov/omim/609013
OMA	VFTFMAG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VFTFMAG
OrthoDB	EOG091G02FX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02FX
PANTHER	PTHR11388	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11388
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PROSITE	PS51465	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51465
PSORT	swissprot:SO4C1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SO4C1_HUMAN
PSORT-B	swissprot:SO4C1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SO4C1_HUMAN
PSORT2	swissprot:SO4C1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SO4C1_HUMAN
Pfam	PF03137	http://pfam.xfam.org/family/PF03137
Pfam	PF07648	http://pfam.xfam.org/family/PF07648
PharmGKB	PA134892408	http://www.pharmgkb.org/do/serve?objId=PA134892408&objCls=Gene
Phobius	swissprot:SO4C1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SO4C1_HUMAN
PhylomeDB	Q6ZQN7	http://phylomedb.org/?seqid=Q6ZQN7
ProteinModelPortal	Q6ZQN7	http://www.proteinmodelportal.org/query/uniprot/Q6ZQN7
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	14993604	http://www.ncbi.nlm.nih.gov/pubmed/14993604
PubMed	17314201	http://www.ncbi.nlm.nih.gov/pubmed/17314201
Reactome	R-HSA-6798695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6798695
Reactome	R-HSA-879518	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-879518
RefSeq	NP_851322	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_851322
STRING	9606.ENSP00000309741	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000309741&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.60.1.11	http://www.tcdb.org/search/result.php?tc=2.A.60.1.11
TIGRFAMs	TIGR00805	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00805
UCSC	uc003knm	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003knm&org=rat
UniGene	Hs.127648	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.127648
UniProtKB	SO4C1_HUMAN	http://www.uniprot.org/uniprot/SO4C1_HUMAN
UniProtKB-AC	Q6ZQN7	http://www.uniprot.org/uniprot/Q6ZQN7
charge	swissprot:SO4C1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SO4C1_HUMAN
eggNOG	ENOG410XRSF	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRSF
eggNOG	KOG3626	http://eggnogapi.embl.de/nog_data/html/tree/KOG3626
epestfind	swissprot:SO4C1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SO4C1_HUMAN
garnier	swissprot:SO4C1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SO4C1_HUMAN
helixturnhelix	swissprot:SO4C1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SO4C1_HUMAN
hmoment	swissprot:SO4C1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SO4C1_HUMAN
iep	swissprot:SO4C1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SO4C1_HUMAN
inforesidue	swissprot:SO4C1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SO4C1_HUMAN
neXtProt	NX_Q6ZQN7	http://www.nextprot.org/db/entry/NX_Q6ZQN7
octanol	swissprot:SO4C1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SO4C1_HUMAN
pepcoil	swissprot:SO4C1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SO4C1_HUMAN
pepdigest	swissprot:SO4C1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SO4C1_HUMAN
pepinfo	swissprot:SO4C1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SO4C1_HUMAN
pepnet	swissprot:SO4C1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SO4C1_HUMAN
pepstats	swissprot:SO4C1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SO4C1_HUMAN
pepwheel	swissprot:SO4C1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SO4C1_HUMAN
pepwindow	swissprot:SO4C1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SO4C1_HUMAN
sigcleave	swissprot:SO4C1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SO4C1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=2; Name=Alpha-1B-1; IsoId=Q00975-1; Sequence=Displayed; Name=Alpha-1B-2; IsoId=Q00975-2; Sequence=VSP_000882; Note=Ref.1 (AAA51898) sequence is in conflict in position: 2215	L->R. {ECO:0000305}; 
# AltName	CAC1B_HUMAN	Brain calcium channel III
# AltName	CAC1B_HUMAN	Calcium channel, L type, alpha-1 polypeptide isoform 5
# AltName	CAC1B_HUMAN	Voltage-gated calcium channel subunit alpha Cav2.2
# BioGrid	107228	7
# CCDS	CCDS59522	-. [Q00975-1]
# CCDS	CCDS59523	-. [Q00975-2]
# ChiTaRS	CACNA1B	human
# DISEASE	CAC1B_HUMAN	Dystonia 23 (DYT23) [MIM 614860]  A form of dystonia, a disorder defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYT23 is an autosomal dominant dystonia affecting the face, neck, limbs. Some DYT23 patients manifest generalized myoclonus in addition to progressive action-induced multifocal dystonia. {ECO 0000269|PubMed 25296916}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	CAC1B_HUMAN	Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position. 
# DrugBank	DB00381	Amlodipine
# DrugBank	DB00421	Spironolactone
# DrugBank	DB00661	Verapamil
# DrugBank	DB00996	Gabapentin
# DrugBank	DB01202	Levetiracetam
# Ensembl	ENST00000277551	ENSP00000277551; ENSG00000148408. [Q00975-2]
# Ensembl	ENST00000371372	ENSP00000360423; ENSG00000148408. [Q00975-1]
# ExpressionAtlas	Q00975	baseline and differential
# FUNCTION	CAC1B_HUMAN	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin- IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005891	voltage-gated calcium channel complex; TAS:ProtInc.
# GO_component	GO:0030425	dendrite; IEA:Ensembl.
# GO_component	GO:0043025	neuronal cell body; IEA:Ensembl.
# GO_component	GO:0098793	presynapse; IEA:GOC.
# GO_function	GO:0005245	voltage-gated calcium channel activity; TAS:ProtInc.
# GO_function	GO:0005262	calcium channel activity; TAS:Reactome.
# GO_function	GO:0005509	calcium ion binding; IEA:InterPro.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0008022	protein C-terminus binding; IPI:UniProtKB.
# GO_function	GO:0008331	high voltage-gated calcium channel activity; IBA:GO_Central.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:ProtInc.
# GO_process	GO:0007269	neurotransmitter secretion; IEA:Ensembl.
# GO_process	GO:0007626	locomotory behavior; IEA:Ensembl.
# GO_process	GO:0008016	regulation of heart contraction; IEA:Ensembl.
# GO_process	GO:0008217	regulation of blood pressure; IEA:Ensembl.
# GO_process	GO:0048265	response to pain; IEA:Ensembl.
# GO_process	GO:0051899	membrane depolarization; TAS:Reactome.
# GO_process	GO:0051924	regulation of calcium ion transport; IEA:Ensembl.
# GO_process	GO:0086010	membrane depolarization during action potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.20.120.350	-; 4.
# Genevisible	Q00975	HS
# HGNC	HGNC:1389	CACNA1B
# INTERACTION	CAC1B_HUMAN	P20650 Ppm1a (xeno); NbExp=3; IntAct=EBI-1055161, EBI-7491743; P28702 RXRB; NbExp=3; IntAct=EBI-1055161, EBI-748576; 
# IntAct	Q00975	7
# InterPro	IPR002048	EF_hand_dom
# InterPro	IPR002077	VDCCAlpha1
# InterPro	IPR005447	VDCC_N_a1su
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR014873	VDCC_a1su_IQ
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR031649	GPHH_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04010	MAPK signaling pathway
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04725	Cholinergic synapse
# KEGG_Pathway	ko04726	Serotonergic synapse
# KEGG_Pathway	ko04727	GABAergic synapse
# KEGG_Pathway	ko04728	Dopaminergic synapse
# KEGG_Pathway	ko04742	Taste transduction
# KEGG_Pathway	ko04930	Type II diabetes mellitus
# KEGG_Pathway	ko05032	Morphine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# MIM	601012	gene
# MIM	614860	phenotype
# Organism	CAC1B_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10037:SF161	PTHR10037:SF161; 3
# PDB	2LCM	NMR; -; A=1242-1269
# PIR	A42566	A42566
# PIR	T45115	T45115
# PRINTS	PR00167	CACHANNEL
# PRINTS	PR01631	NVDCCALPHA1
# PROSITE	PS50222	EF_HAND_2
# PTM	CAC1B_HUMAN	Phosphorylated in vitro by CaM-kinase II, PKA, PKC and CGPK. {ECO 0000250}. 
# Pfam	PF00520	Ion_trans; 4
# Pfam	PF08763	Ca_chan_IQ
# Pfam	PF16905	GPHH
# Proteomes	UP000005640	Chromosome 9
# Reactome	R-HSA-112308	Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
# RecName	CAC1B_HUMAN	Voltage-dependent N-type calcium channel subunit alpha-1B
# RefSeq	NP_000709	NM_000718.3. [Q00975-1]
# RefSeq	NP_001230741	NM_001243812.1. [Q00975-2]
# SIMILARITY	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1B subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 EF-hand domain. {ECO:0000255|PROSITE- ProRule	PRU00448}.
# SMART	SM01062	Ca_chan_IQ
# SUBCELLULAR LOCATION	CAC1B_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	CAC1B_HUMAN	Multisubunit complex consisting of alpha-1, alpha-2, beta and delta subunits in a 1 1 1 1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with RIMS1. Interacts with FMR1 (via C-terminus); this interaction induces a deacrease in the number of presynaptic functional CACNA1B channels at the cell surface. {ECO 0000250|UniProtKB O55017}. 
# TISSUE SPECIFICITY	CAC1B_HUMAN	Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta. 
# UCSC	uc064xny	human. [Q00975-1]
# eggNOG	ENOG410XNP6	LUCA
# eggNOG	KOG2301	Eukaryota
BLAST	swissprot:CAC1B_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CAC1B_HUMAN
BioCyc	ZFISH:ENSG00000148408-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000148408-MONOMER
COXPRESdb	774	http://coxpresdb.jp/data/gene/774.shtml
CleanEx	HS_CACNA1B	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CACNA1B
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
DOI	10.1074/jbc.272.8.5098	http://dx.doi.org/10.1074/jbc.272.8.5098
DOI	10.1093/hmg/ddu513	http://dx.doi.org/10.1093/hmg/ddu513
DOI	10.1126/science.1321501	http://dx.doi.org/10.1126/science.1321501
DrugBank	DB00381	http://www.drugbank.ca/drugs/DB00381
DrugBank	DB00421	http://www.drugbank.ca/drugs/DB00421
DrugBank	DB00661	http://www.drugbank.ca/drugs/DB00661
DrugBank	DB00996	http://www.drugbank.ca/drugs/DB00996
DrugBank	DB01202	http://www.drugbank.ca/drugs/DB01202
EMBL	AL591424	http://www.ebi.ac.uk/ena/data/view/AL591424
EMBL	AL591424	http://www.ebi.ac.uk/ena/data/view/AL591424
EMBL	AL772363	http://www.ebi.ac.uk/ena/data/view/AL772363
EMBL	AL772363	http://www.ebi.ac.uk/ena/data/view/AL772363
EMBL	M94172	http://www.ebi.ac.uk/ena/data/view/M94172
EMBL	M94173	http://www.ebi.ac.uk/ena/data/view/M94173
EMBL	U76666	http://www.ebi.ac.uk/ena/data/view/U76666
Ensembl	ENST00000277551	http://www.ensembl.org/id/ENST00000277551
Ensembl	ENST00000371372	http://www.ensembl.org/id/ENST00000371372
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005891
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0098793	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098793
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0008022	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008022
GO_function	GO:0008331	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008331
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007269	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007269
GO_process	GO:0007626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007626
GO_process	GO:0008016	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008016
GO_process	GO:0008217	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008217
GO_process	GO:0048265	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048265
GO_process	GO:0051899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051899
GO_process	GO:0051924	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051924
GO_process	GO:0086010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086010
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	CACNA1B	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CACNA1B
GeneID	774	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=774
GeneTree	ENSGT00830000128247	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00830000128247
HGNC	HGNC:1389	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1389
HOGENOM	HOG000231530	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231530&db=HOGENOM6
HOVERGEN	HBG050763	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050763&db=HOVERGEN
HPA	HPA044347	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA044347
InParanoid	Q00975	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q00975
IntAct	Q00975	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q00975*
InterPro	IPR002048	http://www.ebi.ac.uk/interpro/entry/IPR002048
InterPro	IPR002077	http://www.ebi.ac.uk/interpro/entry/IPR002077
InterPro	IPR005447	http://www.ebi.ac.uk/interpro/entry/IPR005447
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR014873	http://www.ebi.ac.uk/interpro/entry/IPR014873
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR031649	http://www.ebi.ac.uk/interpro/entry/IPR031649
Jabion	774	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=774
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:774	http://www.genome.jp/dbget-bin/www_bget?hsa:774
KEGG_Orthology	KO:K04849	http://www.genome.jp/dbget-bin/www_bget?KO:K04849
KEGG_Pathway	ko04010	http://www.genome.jp/kegg-bin/show_pathway?ko04010
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04725	http://www.genome.jp/kegg-bin/show_pathway?ko04725
KEGG_Pathway	ko04726	http://www.genome.jp/kegg-bin/show_pathway?ko04726
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
KEGG_Pathway	ko04728	http://www.genome.jp/kegg-bin/show_pathway?ko04728
KEGG_Pathway	ko04742	http://www.genome.jp/kegg-bin/show_pathway?ko04742
KEGG_Pathway	ko04930	http://www.genome.jp/kegg-bin/show_pathway?ko04930
KEGG_Pathway	ko05032	http://www.genome.jp/kegg-bin/show_pathway?ko05032
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
MIM	601012	http://www.ncbi.nlm.nih.gov/omim/601012
MIM	614860	http://www.ncbi.nlm.nih.gov/omim/614860
MINT	MINT-102376	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-102376
PANTHER	PTHR10037:SF161	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10037:SF161
PDB	2LCM	http://www.ebi.ac.uk/pdbe-srv/view/entry/2LCM
PDBsum	2LCM	http://www.ebi.ac.uk/pdbsum/2LCM
PRINTS	PR00167	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00167
PRINTS	PR01631	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01631
PROSITE	PS50222	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50222
PSORT	swissprot:CAC1B_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CAC1B_HUMAN
PSORT-B	swissprot:CAC1B_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CAC1B_HUMAN
PSORT2	swissprot:CAC1B_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CAC1B_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF08763	http://pfam.xfam.org/family/PF08763
Pfam	PF16905	http://pfam.xfam.org/family/PF16905
PharmGKB	PA26008	http://www.pharmgkb.org/do/serve?objId=PA26008&objCls=Gene
Phobius	swissprot:CAC1B_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CAC1B_HUMAN
PhylomeDB	Q00975	http://phylomedb.org/?seqid=Q00975
ProteinModelPortal	Q00975	http://www.proteinmodelportal.org/query/uniprot/Q00975
PubMed	1321501	http://www.ncbi.nlm.nih.gov/pubmed/1321501
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
PubMed	25296916	http://www.ncbi.nlm.nih.gov/pubmed/25296916
PubMed	9030575	http://www.ncbi.nlm.nih.gov/pubmed/9030575
Reactome	R-HSA-112308	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112308
RefSeq	NP_000709	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000709
RefSeq	NP_001230741	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001230741
SMART	SM01062	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01062
SMR	Q00975	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q00975
STRING	9606.ENSP00000360406	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000360406&targetmode=cogs
UCSC	uc064xny	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc064xny&org=rat
UniGene	Hs.495522	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.495522
UniProtKB	CAC1B_HUMAN	http://www.uniprot.org/uniprot/CAC1B_HUMAN
UniProtKB-AC	Q00975	http://www.uniprot.org/uniprot/Q00975
charge	swissprot:CAC1B_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CAC1B_HUMAN
eggNOG	ENOG410XNP6	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNP6
eggNOG	KOG2301	http://eggnogapi.embl.de/nog_data/html/tree/KOG2301
epestfind	swissprot:CAC1B_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CAC1B_HUMAN
garnier	swissprot:CAC1B_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CAC1B_HUMAN
helixturnhelix	swissprot:CAC1B_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CAC1B_HUMAN
hmoment	swissprot:CAC1B_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CAC1B_HUMAN
iep	swissprot:CAC1B_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CAC1B_HUMAN
inforesidue	swissprot:CAC1B_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CAC1B_HUMAN
neXtProt	NX_Q00975	http://www.nextprot.org/db/entry/NX_Q00975
octanol	swissprot:CAC1B_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CAC1B_HUMAN
pepcoil	swissprot:CAC1B_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CAC1B_HUMAN
pepdigest	swissprot:CAC1B_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CAC1B_HUMAN
pepinfo	swissprot:CAC1B_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CAC1B_HUMAN
pepnet	swissprot:CAC1B_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CAC1B_HUMAN
pepstats	swissprot:CAC1B_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CAC1B_HUMAN
pepwheel	swissprot:CAC1B_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CAC1B_HUMAN
pepwindow	swissprot:CAC1B_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CAC1B_HUMAN
sigcleave	swissprot:CAC1B_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CAC1B_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S39A9_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9NUM3-1; Sequence=Displayed; Name=2; IsoId=Q9NUM3-2; Sequence=VSP_027302; Name=3; IsoId=Q9NUM3-3; Sequence=VSP_054057, VSP_054058; 
# AltName	S39A9_HUMAN	Solute carrier family 39 member 9
# AltName	S39A9_HUMAN	Zrt- and Irt-like protein 9
# BioGrid	120615	44
# CCDS	CCDS58327	-. [Q9NUM3-3]
# CCDS	CCDS58328	-. [Q9NUM3-2]
# CCDS	CCDS9795	-. [Q9NUM3-1]
# ChiTaRS	SLC39A9	human
# Ensembl	ENST00000336643	ENSP00000336887; ENSG00000029364. [Q9NUM3-1]
# Ensembl	ENST00000555840	ENSP00000450639; ENSG00000029364. [Q9NUM3-1]
# Ensembl	ENST00000556605	ENSP00000452385; ENSG00000029364. [Q9NUM3-3]
# Ensembl	ENST00000557046	ENSP00000451833; ENSG00000029364. [Q9NUM3-2]
# ExpressionAtlas	Q9NUM3	baseline and differential
# FUNCTION	S39A9_HUMAN	May act as a zinc-influx transporter. {ECO 0000250}. 
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0046873	metal ion transmembrane transporter activity; IEA:InterPro.
# GO_process	GO:0006829	zinc II ion transport; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q9NUM3	HS
# HGNC	HGNC:20182	SLC39A9
# InterPro	IPR003689	ZIP
# KEGG_Brite	ko02001	Solute carrier family
# Organism	S39A9_HUMAN	Homo sapiens (Human)
# Pfam	PF02535	Zip
# Proteomes	UP000005640	Chromosome 14
# RecName	S39A9_HUMAN	Zinc transporter ZIP9
# RefSeq	NP_001239077	NM_001252148.1. [Q9NUM3-2]
# RefSeq	NP_001239079	NM_001252150.1. [Q9NUM3-3]
# RefSeq	NP_001239080	NM_001252151.1
# RefSeq	NP_001239081	NM_001252152.1
# RefSeq	NP_060845	NM_018375.4. [Q9NUM3-1]
# SIMILARITY	Belongs to the ZIP transporter (TC 2.A.5) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S39A9_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	2.A.5.6	the zinc (zn(2+))-iron (fe(2+)) permease (zip) family
# TopDownProteomics	Q9NUM3-2	-. [Q9NUM3-2]
# UCSC	uc001xle	human. [Q9NUM3-1]
# eggNOG	ENOG410XQG5	LUCA
# eggNOG	KOG3907	Eukaryota
BLAST	swissprot:S39A9_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S39A9_HUMAN
BioCyc	ZFISH:ENSG00000029364-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000029364-MONOMER
COXPRESdb	55334	http://coxpresdb.jp/data/gene/55334.shtml
CleanEx	HS_SLC39A9	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC39A9
DOI	10.1038/nature01348	http://dx.doi.org/10.1038/nature01348
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AK002136	http://www.ebi.ac.uk/ena/data/view/AK002136
EMBL	AK222547	http://www.ebi.ac.uk/ena/data/view/AK222547
EMBL	AL157996	http://www.ebi.ac.uk/ena/data/view/AL157996
EMBL	AY358687	http://www.ebi.ac.uk/ena/data/view/AY358687
EMBL	AY780789	http://www.ebi.ac.uk/ena/data/view/AY780789
EMBL	BC047682	http://www.ebi.ac.uk/ena/data/view/BC047682
EMBL	BC064383	http://www.ebi.ac.uk/ena/data/view/BC064383
Ensembl	ENST00000336643	http://www.ensembl.org/id/ENST00000336643
Ensembl	ENST00000555840	http://www.ensembl.org/id/ENST00000555840
Ensembl	ENST00000556605	http://www.ensembl.org/id/ENST00000556605
Ensembl	ENST00000557046	http://www.ensembl.org/id/ENST00000557046
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0046873	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046873
GO_process	GO:0006829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006829
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC39A9	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC39A9
GeneID	55334	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55334
GeneTree	ENSGT00390000010094	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000010094
H-InvDB	HIX0011767	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0011767
HGNC	HGNC:20182	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20182
HOGENOM	HOG000164405	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000164405&db=HOGENOM6
HOVERGEN	HBG055074	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG055074&db=HOVERGEN
HPA	HPA007921	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA007921
InParanoid	Q9NUM3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NUM3
IntAct	Q9NUM3	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NUM3*
InterPro	IPR003689	http://www.ebi.ac.uk/interpro/entry/IPR003689
Jabion	55334	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55334
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:55334	http://www.genome.jp/dbget-bin/www_bget?hsa:55334
KEGG_Orthology	KO:K14715	http://www.genome.jp/dbget-bin/www_bget?KO:K14715
OMA	SELIIMI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SELIIMI
OrthoDB	EOG091G0IZE	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0IZE
PSORT	swissprot:S39A9_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S39A9_HUMAN
PSORT-B	swissprot:S39A9_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S39A9_HUMAN
PSORT2	swissprot:S39A9_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S39A9_HUMAN
Pfam	PF02535	http://pfam.xfam.org/family/PF02535
PharmGKB	PA134889179	http://www.pharmgkb.org/do/serve?objId=PA134889179&objCls=Gene
Phobius	swissprot:S39A9_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S39A9_HUMAN
PhylomeDB	Q9NUM3	http://phylomedb.org/?seqid=Q9NUM3
ProteinModelPortal	Q9NUM3	http://www.proteinmodelportal.org/query/uniprot/Q9NUM3
PubMed	12508121	http://www.ncbi.nlm.nih.gov/pubmed/12508121
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
RefSeq	NP_001239077	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001239077
RefSeq	NP_001239079	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001239079
RefSeq	NP_001239080	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001239080
RefSeq	NP_001239081	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001239081
RefSeq	NP_060845	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060845
STRING	9606.ENSP00000336887	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000336887&targetmode=cogs
TCDB	2.A.5.6	http://www.tcdb.org/search/result.php?tc=2.A.5.6
UCSC	uc001xle	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001xle&org=rat
UniGene	Hs.432690	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.432690
UniProtKB	S39A9_HUMAN	http://www.uniprot.org/uniprot/S39A9_HUMAN
UniProtKB-AC	Q9NUM3	http://www.uniprot.org/uniprot/Q9NUM3
charge	swissprot:S39A9_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S39A9_HUMAN
eggNOG	ENOG410XQG5	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQG5
eggNOG	KOG3907	http://eggnogapi.embl.de/nog_data/html/tree/KOG3907
epestfind	swissprot:S39A9_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S39A9_HUMAN
garnier	swissprot:S39A9_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S39A9_HUMAN
helixturnhelix	swissprot:S39A9_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S39A9_HUMAN
hmoment	swissprot:S39A9_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S39A9_HUMAN
iep	swissprot:S39A9_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S39A9_HUMAN
inforesidue	swissprot:S39A9_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S39A9_HUMAN
neXtProt	NX_Q9NUM3	http://www.nextprot.org/db/entry/NX_Q9NUM3
octanol	swissprot:S39A9_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S39A9_HUMAN
pepcoil	swissprot:S39A9_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S39A9_HUMAN
pepdigest	swissprot:S39A9_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S39A9_HUMAN
pepinfo	swissprot:S39A9_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S39A9_HUMAN
pepnet	swissprot:S39A9_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S39A9_HUMAN
pepstats	swissprot:S39A9_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S39A9_HUMAN
pepwheel	swissprot:S39A9_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S39A9_HUMAN
pepwindow	swissprot:S39A9_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S39A9_HUMAN
sigcleave	swissprot:S39A9_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S39A9_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNH1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=2; Synonyms=hEAGB; IsoId=O95259-1; Sequence=Displayed; Name=1; Synonyms=hEAG; IsoId=O95259-2; Sequence=VSP_000964; 
# AltName	Ether-a-go-go potassium channel 1 {ECO:0000303|PubMed	27325704}
# AltName	KCNH1_HUMAN	Voltage-gated potassium channel subunit Kv10.1
# BioGrid	109958	7
# CCDS	CCDS1496	-. [O95259-1]
# CCDS	CCDS31015	-. [O95259-2]
# DISEASE	KCNH1_HUMAN	Temple-Baraitser syndrome (TMBTS) [MIM 611816]  A developmental disorder characterized by intellectual disability, epilepsy, hypoplasia or aplasia of the thumb and great toe nails, and broadening and/or elongation of the thumbs and halluces, which have a tubular aspect. Some patients show facial dysmorphism. {ECO 0000269|PubMed 25420144}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	KCNH1_HUMAN	Zimmermann-Laband syndrome 1 (ZLS1) [MIM 135500]  A disorder characterized by gingival fibromatosis, dysplastic or absent nails, finger abnormalities, hepatosplenomegaly, and abnormalities of the cartilage of the nose and/or ears. {ECO 0000269|PubMed 25915598}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	KCNH1_HUMAN	The C-terminal region interacts with the cyclic nucleotide-binding domain and contributes to regulate channel gating. {ECO 0000250|UniProtKB Q60603}. 
# DOMAIN	KCNH1_HUMAN	The PAS and PAC domain interact with the cyclic nucleotide-binding domain and contribute to the regulation of channel gating (PubMed 27325704). Calmodulin binding clamps together the PAS and PAC domain with the cyclic nucleotide-binding domain from a neighboring subunit and causes a conformation change that leads to channel closure. {ECO 0000250|UniProtKB Q63472, ECO 0000269|PubMed 27325704}. 
# DOMAIN	KCNH1_HUMAN	The cyclic nucleotide-binding domain lacks residues that are essential for nucleotide-binding and cannot bind cyclic nucleotides. Instead, residues from the C-terminal domain (the so- called intrinsic ligand) bind in the cavity that would be expected to bind cyclic nucleotides. Interaction with the C-terminal region hinders interaction with CALM and reduces the affinity for CALM. {ECO 0000250|UniProtKB Q60603}. 
# DOMAIN	KCNH1_HUMAN	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. {ECO 0000250|UniProtKB Q63472}. 
# ENZYME REGULATION	KCNH1_HUMAN	Channel activity is inhibited by interaction with Ca(2+)-bound calmodulin (PubMed 10880439, PubMed 27325704, PubMed 27005320, PubMed 27618660). Interaction of a single pore- forming alpha subunit with a calmodulin chain is sufficient to promote channel closure (PubMed 10880439). Channel activity is not regulated by cyclic nucleotides (By similarity). Channel activity is inhibited by binding intracellular phosphatidylinositol-3,5- bisphosphate and phosphatidylinositol-4,5-bisphosphate (PIP2), but is not inhibited by phosphatidylinositol 4-phosphate (PubMed 27005320). {ECO 0000250|UniProtKB Q60603, ECO 0000269|PubMed 10880439, ECO 0000269|PubMed 27005320, ECO 0000269|PubMed 27325704, ECO 0000269|PubMed 27618660}. 
# Ensembl	ENST00000271751	ENSP00000271751; ENSG00000143473. [O95259-1]
# Ensembl	ENST00000367007	ENSP00000355974; ENSG00000143473. [O95259-2]
# FUNCTION	KCNH1_HUMAN	Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed 9738473, PubMed 11943152, PubMed 10880439, PubMed 22732247, PubMed 25556795, PubMed 27325704, PubMed 27005320, PubMed 27618660). Channel properties are modulated by subunit assembly (PubMed 11943152). Mediates IK(NI) current in myoblasts (PubMed 9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed 23881642). {ECO 0000269|PubMed 10880439, ECO 0000269|PubMed 11943152, ECO 0000269|PubMed 22732247, ECO 0000269|PubMed 23881642, ECO 0000269|PubMed 25556795, ECO 0000269|PubMed 27005320, ECO 0000269|PubMed 27325704, ECO 0000269|PubMed 27618660, ECO 0000269|PubMed 9738473}. 
# GO_component	GO:0005637	nuclear inner membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IDA:UniProtKB.
# GO_component	GO:0009986	cell surface; IEA:Ensembl.
# GO_component	GO:0030425	dendrite; IEA:Ensembl.
# GO_component	GO:0030673	axolemma; IEA:Ensembl.
# GO_component	GO:0031901	early endosome membrane; IDA:UniProtKB.
# GO_component	GO:0042734	presynaptic membrane; IEA:Ensembl.
# GO_component	GO:0043025	neuronal cell body; IEA:Ensembl.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IEA:Ensembl.
# GO_function	GO:0000155	phosphorelay sensor kinase activity; IEA:InterPro.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; IDA:UniProtKB.
# GO_function	GO:1902936	phosphatidylinositol bisphosphate binding; IDA:UniProtKB.
# GO_process	GO:0001964	startle response; IEA:Ensembl.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0007520	myoblast fusion; TAS:ProtInc.
# GO_process	GO:0042127	regulation of cell proliferation; IMP:UniProtKB.
# GO_process	GO:0042391	regulation of membrane potential; IBA:GO_Central.
# GO_process	GO:0048015	phosphatidylinositol-mediated signaling; IMP:UniProtKB.
# GO_process	GO:0071277	cellular response to calcium ion; IMP:UniProtKB.
# GO_process	GO:0071805	potassium ion transmembrane transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0008289	lipid binding
# GOslim_function	GO:0016301	kinase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048646	anatomical structure formation involved in morphogenesis
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.120.10	-; 1.
# Genevisible	O95259	HS
# HGNC	HGNC:6250	KCNH1
# INTERACTION	KCNH1_HUMAN	P62158 CALM3; NbExp=8; IntAct=EBI-9836801, EBI-397435; Q7L8L6 FASTKD5; NbExp=3; IntAct=EBI-2909270, EBI-747570; P02638 S100B (xeno); NbExp=3; IntAct=EBI-2909270, EBI-458452; O00560 SDCBP; NbExp=3; IntAct=EBI-2909270, EBI-727004; Q96HA8 WDYHV1; NbExp=3; IntAct=EBI-2909270, EBI-741158; 
# IntAct	O95259	10
# InterPro	IPR000014	PAS
# InterPro	IPR000595	cNMP-bd_dom
# InterPro	IPR000700	PAS-assoc_C
# InterPro	IPR001610	PAC
# InterPro	IPR003938	K_chnl_volt-dep_EAG/ELK/ERG
# InterPro	IPR003949	K_chnl_volt-dep_EAG
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR014710	RmlC-like_jellyroll
# InterPro	IPR018490	cNMP-bd-like
# KEGG_Brite	ko04040	Ion channels
# KEGG_Disease	H01573	[Skeletal dysplasia; Developmental disorder] Zimmermann-Laband syndrome (ZLS)
# MIM	135500	phenotype
# MIM	603305	gene
# MIM	611816	phenotype
# Organism	KCNH1_HUMAN	Homo sapiens (Human)
# PDB	5J7E	X-ray; 1.90 A; A/B/C/D/E/F=1-146
# PRINTS	PR01463	EAGCHANLFMLY
# PRINTS	PR01464	EAGCHANNEL
# PROSITE	PS50042	CNMP_BINDING_3
# PROSITE	PS50112	PAS
# PROSITE	PS50113	PAC
# PTM	KCNH1_HUMAN	Channel activity is regulated via tyrosine phosphorylation/dephosphorylation by SRC and PTPN6 (PubMed 24587194). {ECO 0000269|PubMed 24587194}. 
# Pfam	PF00027	cNMP_binding
# Pfam	PF00520	Ion_trans
# Pfam	PF13426	PAS_9
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# RecName	KCNH1_HUMAN	Potassium voltage-gated channel subfamily H member 1
# RefSeq	NP_002229	NM_002238.3. [O95259-2]
# RefSeq	NP_758872	NM_172362.2. [O95259-1]
# SIMILARITY	Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv10.1/KCNH1 sub-subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 PAC (PAS-associated C-terminal) domain. {ECO:0000255|PROSITE-ProRule	PRU00141}. 
# SIMILARITY	Contains 1 PAS (PER-ARNT-SIM) domain. {ECO:0000255|PROSITE-ProRule	PRU00140}. 
# SIMILARITY	Contains 1 cyclic nucleotide-binding domain. {ECO:0000255|PROSITE-ProRule	PRU00060}. 
# SMART	SM00086	PAC
# SMART	SM00100	cNMP
# SUBCELLULAR LOCATION	KCNH1_HUMAN	Cell membrane {ECO 0000269|PubMed 10880439, ECO 0000269|PubMed 11943152, ECO 0000269|PubMed 21559285, ECO 0000269|PubMed 22732247, ECO 0000269|PubMed 22841712, ECO 0000269|PubMed 25556795, ECO 0000269|PubMed 27005320, ECO 0000269|PubMed 27325704, ECO 0000269|PubMed 27618660, ECO 0000269|PubMed 9738473}; Multi-pass membrane protein {ECO 0000269|PubMed 21559285}. Nucleus inner membrane {ECO 0000269|PubMed 21559285}; Multi-pass membrane protein {ECO 0000269|PubMed 21559285}. Cell projection, dendrite {ECO 0000250|UniProtKB Q63472}. Cell projection, axon {ECO 0000250|UniProtKB Q63472}. Cell junction, synapse, presynaptic cell membrane {ECO 0000250|UniProtKB Q63472}. Perikaryon {ECO 0000250|UniProtKB Q63472}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO 0000250|UniProtKB Q63472}. Early endosome membrane {ECO 0000269|PubMed 22841712}. Note=Perinuclear KCNH1 is located to NPC-free islands. 
# SUBUNIT	KCNH1_HUMAN	The potassium channel is composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH5/EAG2 (PubMed 11943152). Interacts with ALG10B (By similarity). Interacts with RABEP1 (By similarity). Interacts (via C-terminus) with CTTN (PubMed 23144454). Interacts (via C-terminal cytoplasmic region) with Ca(2+)-bound calmodulin (PubMed 10880439, PubMed 27325704, PubMed 27618660). {ECO 0000250|UniProtKB Q63472, ECO 0000269|PubMed 10880439, ECO 0000269|PubMed 11943152, ECO 0000269|PubMed 23144454, ECO 0000269|PubMed 27325704, ECO 0000269|PubMed 27618660}. 
# SUPFAM	SSF51206	SSF51206
# SUPFAM	SSF55785	SSF55785
# TCDB	1.I.1.1	the nuclear pore complex (npc) family
# TIGRFAMs	TIGR00229	sensory_box
# TISSUE SPECIFICITY	KCNH1_HUMAN	Highly expressed in brain and in myoblasts at the onset of fusion, but not in other tissues. Detected in HeLa (cervical carcinoma), SH-SY5Y (neuroblastoma) and MCF-7 (epithelial tumor) cells, but not in normal epithelial cells. 
# UCSC	uc001hib	human. [O95259-1]
# WEB RESOURCE	KCNH1_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/KCNH1ID41048ch1q32.html";
# eggNOG	ENOG410XPSE	LUCA
# eggNOG	KOG0498	Eukaryota
BLAST	swissprot:KCNH1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNH1_HUMAN
BioCyc	ZFISH:ENSG00000143473-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000143473-MONOMER
COXPRESdb	3756	http://coxpresdb.jp/data/gene/3756.shtml
CleanEx	HS_KCNH1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNH1
DOI	10.1002/jcp.24435	http://dx.doi.org/10.1002/jcp.24435
DOI	10.1016/S0014-5793(02)02365-7	http://dx.doi.org/10.1016/S0014-5793(02)02365-7
DOI	10.1016/S0014-5793(98)00973-9	http://dx.doi.org/10.1016/S0014-5793(98)00973-9
DOI	10.1016/j.febslet.2012.07.055	http://dx.doi.org/10.1016/j.febslet.2012.07.055
DOI	10.1016/j.jmb.2012.06.025	http://dx.doi.org/10.1016/j.jmb.2012.06.025
DOI	10.1016/j.str.2016.07.020	http://dx.doi.org/10.1016/j.str.2016.07.020
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng.3153	http://dx.doi.org/10.1038/ng.3153
DOI	10.1038/ng.3282	http://dx.doi.org/10.1038/ng.3282
DOI	10.1038/srep23417	http://dx.doi.org/10.1038/srep23417
DOI	10.1074/jbc.M112.372540	http://dx.doi.org/10.1074/jbc.M112.372540
DOI	10.1074/jbc.M116.733576	http://dx.doi.org/10.1074/jbc.M116.733576
DOI	10.1093/emboj/18.20.5540	http://dx.doi.org/10.1093/emboj/18.20.5540
DOI	10.1093/emboj/19.13.3263	http://dx.doi.org/10.1093/emboj/19.13.3263
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1113/jphysiol.2014.281600	http://dx.doi.org/10.1113/jphysiol.2014.281600
DOI	10.1371/journal.pone.0019257	http://dx.doi.org/10.1371/journal.pone.0019257
DOI	10.1371/journal.pone.0090024	http://dx.doi.org/10.1371/journal.pone.0090024
EMBL	AC092017	http://www.ebi.ac.uk/ena/data/view/AC092017
EMBL	AC092017	http://www.ebi.ac.uk/ena/data/view/AC092017
EMBL	AC096636	http://www.ebi.ac.uk/ena/data/view/AC096636
EMBL	AC096636	http://www.ebi.ac.uk/ena/data/view/AC096636
EMBL	AC099755	http://www.ebi.ac.uk/ena/data/view/AC099755
EMBL	AC099755	http://www.ebi.ac.uk/ena/data/view/AC099755
EMBL	AF078741	http://www.ebi.ac.uk/ena/data/view/AF078741
EMBL	AF078742	http://www.ebi.ac.uk/ena/data/view/AF078742
EMBL	AJ001366	http://www.ebi.ac.uk/ena/data/view/AJ001366
EMBL	AL590132	http://www.ebi.ac.uk/ena/data/view/AL590132
EMBL	AL590132	http://www.ebi.ac.uk/ena/data/view/AL590132
EMBL	BC113709	http://www.ebi.ac.uk/ena/data/view/BC113709
EMBL	BC143599	http://www.ebi.ac.uk/ena/data/view/BC143599
EMBL	CH471100	http://www.ebi.ac.uk/ena/data/view/CH471100
EMBL	CH471100	http://www.ebi.ac.uk/ena/data/view/CH471100
Ensembl	ENST00000271751	http://www.ensembl.org/id/ENST00000271751
Ensembl	ENST00000367007	http://www.ensembl.org/id/ENST00000367007
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005637	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005637
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0030673	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030673
GO_component	GO:0031901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031901
GO_component	GO:0042734	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042734
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_function	GO:0000155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_function	GO:1902936	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902936
GO_process	GO:0001964	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001964
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0007520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007520
GO_process	GO:0042127	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042127
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0048015	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048015
GO_process	GO:0071277	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071277
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GOslim_function	GO:0016301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048646	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048646
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.120.10	http://www.cathdb.info/version/latest/superfamily/2.60.120.10
GeneCards	KCNH1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNH1
GeneID	3756	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3756
GeneTree	ENSGT00760000118772	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118772
HGNC	HGNC:6250	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6250
HOGENOM	HOG000230794	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230794&db=HOGENOM6
HOVERGEN	HBG101348	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG101348&db=HOVERGEN
HPA	HPA019445	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA019445
InParanoid	O95259	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O95259
IntAct	O95259	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O95259*
InterPro	IPR000014	http://www.ebi.ac.uk/interpro/entry/IPR000014
InterPro	IPR000595	http://www.ebi.ac.uk/interpro/entry/IPR000595
InterPro	IPR000700	http://www.ebi.ac.uk/interpro/entry/IPR000700
InterPro	IPR001610	http://www.ebi.ac.uk/interpro/entry/IPR001610
InterPro	IPR003938	http://www.ebi.ac.uk/interpro/entry/IPR003938
InterPro	IPR003949	http://www.ebi.ac.uk/interpro/entry/IPR003949
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR014710	http://www.ebi.ac.uk/interpro/entry/IPR014710
InterPro	IPR018490	http://www.ebi.ac.uk/interpro/entry/IPR018490
Jabion	3756	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3756
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H01573	http://www.genome.jp/dbget-bin/www_bget?H01573
KEGG_Gene	hsa:3756	http://www.genome.jp/dbget-bin/www_bget?hsa:3756
KEGG_Orthology	KO:K04904	http://www.genome.jp/dbget-bin/www_bget?KO:K04904
MIM	135500	http://www.ncbi.nlm.nih.gov/omim/135500
MIM	603305	http://www.ncbi.nlm.nih.gov/omim/603305
MIM	611816	http://www.ncbi.nlm.nih.gov/omim/611816
MINT	MINT-138319	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-138319
OMA	IRTESWL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IRTESWL
OrthoDB	EOG091G0OXR	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0OXR
PDB	5J7E	http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7E
PDBsum	5J7E	http://www.ebi.ac.uk/pdbsum/5J7E
PRINTS	PR01463	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01463
PRINTS	PR01464	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01464
PROSITE	PS50042	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50042
PROSITE	PS50112	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50112
PROSITE	PS50113	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50113
PSORT	swissprot:KCNH1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNH1_HUMAN
PSORT-B	swissprot:KCNH1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNH1_HUMAN
PSORT2	swissprot:KCNH1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNH1_HUMAN
Pfam	PF00027	http://pfam.xfam.org/family/PF00027
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF13426	http://pfam.xfam.org/family/PF13426
PharmGKB	PA30037	http://www.pharmgkb.org/do/serve?objId=PA30037&objCls=Gene
Phobius	swissprot:KCNH1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNH1_HUMAN
PhylomeDB	O95259	http://phylomedb.org/?seqid=O95259
ProteinModelPortal	O95259	http://www.proteinmodelportal.org/query/uniprot/O95259
PubMed	10523298	http://www.ncbi.nlm.nih.gov/pubmed/10523298
PubMed	10880439	http://www.ncbi.nlm.nih.gov/pubmed/10880439
PubMed	11943152	http://www.ncbi.nlm.nih.gov/pubmed/11943152
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	21559285	http://www.ncbi.nlm.nih.gov/pubmed/21559285
PubMed	22732247	http://www.ncbi.nlm.nih.gov/pubmed/22732247
PubMed	22841712	http://www.ncbi.nlm.nih.gov/pubmed/22841712
PubMed	23144454	http://www.ncbi.nlm.nih.gov/pubmed/23144454
PubMed	23881642	http://www.ncbi.nlm.nih.gov/pubmed/23881642
PubMed	24587194	http://www.ncbi.nlm.nih.gov/pubmed/24587194
PubMed	25420144	http://www.ncbi.nlm.nih.gov/pubmed/25420144
PubMed	25556795	http://www.ncbi.nlm.nih.gov/pubmed/25556795
PubMed	25915598	http://www.ncbi.nlm.nih.gov/pubmed/25915598
PubMed	27005320	http://www.ncbi.nlm.nih.gov/pubmed/27005320
PubMed	27325704	http://www.ncbi.nlm.nih.gov/pubmed/27325704
PubMed	27618660	http://www.ncbi.nlm.nih.gov/pubmed/27618660
PubMed	9738473	http://www.ncbi.nlm.nih.gov/pubmed/9738473
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
RefSeq	NP_002229	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002229
RefSeq	NP_758872	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_758872
SMART	SM00086	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00086
SMART	SM00100	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00100
SMR	O95259	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O95259
STRING	9606.ENSP00000271751	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000271751&targetmode=cogs
SUPFAM	SSF51206	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51206
SUPFAM	SSF55785	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55785
TCDB	1.I.1.1	http://www.tcdb.org/search/result.php?tc=1.I.1.1
TIGRFAMs	TIGR00229	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00229
UCSC	uc001hib	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001hib&org=rat
UniGene	Hs.553187	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.553187
UniProtKB	KCNH1_HUMAN	http://www.uniprot.org/uniprot/KCNH1_HUMAN
UniProtKB-AC	O95259	http://www.uniprot.org/uniprot/O95259
charge	swissprot:KCNH1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNH1_HUMAN
eggNOG	ENOG410XPSE	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPSE
eggNOG	KOG0498	http://eggnogapi.embl.de/nog_data/html/tree/KOG0498
epestfind	swissprot:KCNH1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNH1_HUMAN
garnier	swissprot:KCNH1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNH1_HUMAN
helixturnhelix	swissprot:KCNH1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNH1_HUMAN
hmoment	swissprot:KCNH1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNH1_HUMAN
iep	swissprot:KCNH1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNH1_HUMAN
inforesidue	swissprot:KCNH1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNH1_HUMAN
neXtProt	NX_O95259	http://www.nextprot.org/db/entry/NX_O95259
octanol	swissprot:KCNH1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNH1_HUMAN
pepcoil	swissprot:KCNH1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNH1_HUMAN
pepdigest	swissprot:KCNH1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNH1_HUMAN
pepinfo	swissprot:KCNH1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNH1_HUMAN
pepnet	swissprot:KCNH1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNH1_HUMAN
pepstats	swissprot:KCNH1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNH1_HUMAN
pepwheel	swissprot:KCNH1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNH1_HUMAN
pepwindow	swissprot:KCNH1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNH1_HUMAN
sigcleave	swissprot:KCNH1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNH1_HUMAN
## Database	ID	URL or Descriptions
# AltName	TRPV2_HUMAN	Osm-9-like TRP channel 2
# AltName	TRPV2_HUMAN	Vanilloid receptor-like protein 1
# Ensembl	ENST00000338560	ENSP00000342222; ENSG00000187688
# ExpressionAtlas	Q9Y5S1	baseline and differential
# FUNCTION	TRPV2_HUMAN	Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. {ECO 0000269|PubMed 10201375}. 
# GO_component	GO:0005886	plasma membrane; IDA:MGI.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0009986	cell surface; IEA:Ensembl.
# GO_component	GO:0032584	growth cone membrane; IEA:Ensembl.
# GO_component	GO:0042470	melanosome; IEA:UniProtKB-SubCell.
# GO_component	GO:0044295	axonal growth cone; IEA:Ensembl.
# GO_component	GO:0044297	cell body; IEA:Ensembl.
# GO_function	GO:0005216	ion channel activity; TAS:ProtInc.
# GO_function	GO:0005261	cation channel activity; IDA:MGI.
# GO_function	GO:0005262	calcium channel activity; IBA:GO_Central.
# GO_function	GO:0015075	ion transmembrane transporter activity; TAS:ProtInc.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007600	sensory perception; TAS:ProtInc.
# GO_process	GO:0009266	response to temperature stimulus; IDA:MGI.
# GO_process	GO:0009408	response to heat; IEA:InterPro.
# GO_process	GO:0045773	positive regulation of axon extension; IEA:Ensembl.
# GO_process	GO:0070588	calcium ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0090280	positive regulation of calcium ion import; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.25.40.20	-; 2.
# Genevisible	Q9Y5S1	HS
# HGNC	HGNC:18082	TRPV2
# IntAct	Q9Y5S1	7
# InterPro	IPR002110	Ankyrin_rpt
# InterPro	IPR004729	TRP_channel
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR008347	TRPV1-4_channel
# InterPro	IPR020683	Ankyrin_rpt-contain_dom
# InterPro	IPR024865	TRPV2_channel
# KEGG_Brite	ko04040	Ion channels
# MIM	606676	gene
# Organism	TRPV2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10582:SF5	PTHR10582:SF5; 2
# PDB	2F37	X-ray; 1.70 A; A/B=69-319
# PRINTS	PR01768	TRPVRECEPTOR
# PROSITE	PS50088	ANK_REPEAT
# PROSITE	PS50297	ANK_REP_REGION
# PTM	TRPV2_HUMAN	N-glycosylated. {ECO 0000250}. 
# PTM	TRPV2_HUMAN	Phosphorylated by PKA. {ECO 0000250}. 
# Pfam	PF00520	Ion_trans
# Pfam	PF12796	Ank_2
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-3295583	TRP channels
# RecName	TRPV2_HUMAN	Transient receptor potential cation channel subfamily V member 2
# RefSeq	NP_057197	NM_016113.4
# SIMILARITY	Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 6 ANK repeats. {ECO:0000255|PROSITE- ProRule	PRU00023}. 
# SMART	SM00248	ANK; 4
# SUBCELLULAR LOCATION	TRPV2_HUMAN	Cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Cytoplasm {ECO 0000250}. Melanosome {ECO 0000269|PubMed 17081065}. Note=Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO 0000250}. 
# SUBUNIT	Homotetramer (Probable). Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with SLC50A1; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation (By similarity). {ECO:0000250, ECO	0000305}. 
# SUPFAM	SSF48403	SSF48403
# TCDB	1.A.4.2	the transient receptor potential ca(2+) channel (trp-cc) family
# TIGRFAMs	TIGR00870	trp
# UCSC	uc002gpy	human
# WEB RESOURCE	TRPV2_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/TRPV2ID45817ch17p11.html";
# eggNOG	ENOG4110DG4	LUCA
# eggNOG	KOG3676	Eukaryota
BLAST	swissprot:TRPV2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TRPV2_HUMAN
BioCyc	ZFISH:G66-30851-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-30851-MONOMER
COXPRESdb	51393	http://coxpresdb.jp/data/gene/51393.shtml
CleanEx	HS_TRPV2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TRPV2
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr060363j	http://dx.doi.org/10.1021/pr060363j
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/18906	http://dx.doi.org/10.1038/18906
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1110/ps.062357206	http://dx.doi.org/10.1110/ps.062357206
EMBL	AC093484	http://www.ebi.ac.uk/ena/data/view/AC093484
EMBL	AF103906	http://www.ebi.ac.uk/ena/data/view/AF103906
EMBL	AF129112	http://www.ebi.ac.uk/ena/data/view/AF129112
EMBL	AJ487963	http://www.ebi.ac.uk/ena/data/view/AJ487963
EMBL	AK289705	http://www.ebi.ac.uk/ena/data/view/AK289705
EMBL	BC018926	http://www.ebi.ac.uk/ena/data/view/BC018926
EMBL	BC051305	http://www.ebi.ac.uk/ena/data/view/BC051305
EMBL	CH471222	http://www.ebi.ac.uk/ena/data/view/CH471222
Ensembl	ENST00000338560	http://www.ensembl.org/id/ENST00000338560
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0032584	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032584
GO_component	GO:0042470	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042470
GO_component	GO:0044295	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044295
GO_component	GO:0044297	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044297
GO_function	GO:0005216	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005216
GO_function	GO:0005261	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005261
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0015075	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015075
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007600	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007600
GO_process	GO:0009266	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009266
GO_process	GO:0009408	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408
GO_process	GO:0045773	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045773
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:0090280	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090280
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.25.40.20	http://www.cathdb.info/version/latest/superfamily/1.25.40.20
GeneCards	TRPV2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TRPV2
GeneID	51393	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51393
GeneTree	ENSGT00550000074425	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074425
HGNC	HGNC:18082	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18082
HOGENOM	HOG000234630	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234630&db=HOGENOM6
HOVERGEN	HBG054085	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054085&db=HOVERGEN
HPA	HPA044993	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA044993
InParanoid	Q9Y5S1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y5S1
IntAct	Q9Y5S1	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9Y5S1*
InterPro	IPR002110	http://www.ebi.ac.uk/interpro/entry/IPR002110
InterPro	IPR004729	http://www.ebi.ac.uk/interpro/entry/IPR004729
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR008347	http://www.ebi.ac.uk/interpro/entry/IPR008347
InterPro	IPR020683	http://www.ebi.ac.uk/interpro/entry/IPR020683
InterPro	IPR024865	http://www.ebi.ac.uk/interpro/entry/IPR024865
Jabion	51393	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=51393
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:51393	http://www.genome.jp/dbget-bin/www_bget?hsa:51393
KEGG_Orthology	KO:K04971	http://www.genome.jp/dbget-bin/www_bget?KO:K04971
MIM	606676	http://www.ncbi.nlm.nih.gov/omim/606676
OMA	ICVLEME	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ICVLEME
OrthoDB	EOG091G02AF	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02AF
PANTHER	PTHR10582:SF5	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10582:SF5
PDB	2F37	http://www.ebi.ac.uk/pdbe-srv/view/entry/2F37
PDBsum	2F37	http://www.ebi.ac.uk/pdbsum/2F37
PRINTS	PR01768	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01768
PROSITE	PS50088	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50088
PROSITE	PS50297	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50297
PSORT	swissprot:TRPV2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TRPV2_HUMAN
PSORT-B	swissprot:TRPV2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TRPV2_HUMAN
PSORT2	swissprot:TRPV2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TRPV2_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF12796	http://pfam.xfam.org/family/PF12796
PharmGKB	PA38292	http://www.pharmgkb.org/do/serve?objId=PA38292&objCls=Gene
Phobius	swissprot:TRPV2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TRPV2_HUMAN
PhylomeDB	Q9Y5S1	http://phylomedb.org/?seqid=Q9Y5S1
ProteinModelPortal	Q9Y5S1	http://www.proteinmodelportal.org/query/uniprot/Q9Y5S1
PubMed	10201375	http://www.ncbi.nlm.nih.gov/pubmed/10201375
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	16882997	http://www.ncbi.nlm.nih.gov/pubmed/16882997
PubMed	17081065	http://www.ncbi.nlm.nih.gov/pubmed/17081065
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
Reactome	R-HSA-3295583	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3295583
RefSeq	NP_057197	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_057197
SMART	SM00248	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00248
SMR	Q9Y5S1	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9Y5S1
STRING	9606.ENSP00000342222	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000342222&targetmode=cogs
SUPFAM	SSF48403	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48403
TCDB	1.A.4.2	http://www.tcdb.org/search/result.php?tc=1.A.4.2
TIGRFAMs	TIGR00870	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00870
UCSC	uc002gpy	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002gpy&org=rat
UniGene	Hs.279746	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.279746
UniProtKB	TRPV2_HUMAN	http://www.uniprot.org/uniprot/TRPV2_HUMAN
UniProtKB-AC	Q9Y5S1	http://www.uniprot.org/uniprot/Q9Y5S1
charge	swissprot:TRPV2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TRPV2_HUMAN
eggNOG	ENOG4110DG4	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110DG4
eggNOG	KOG3676	http://eggnogapi.embl.de/nog_data/html/tree/KOG3676
epestfind	swissprot:TRPV2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TRPV2_HUMAN
garnier	swissprot:TRPV2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TRPV2_HUMAN
helixturnhelix	swissprot:TRPV2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRPV2_HUMAN
hmoment	swissprot:TRPV2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TRPV2_HUMAN
iep	swissprot:TRPV2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TRPV2_HUMAN
inforesidue	swissprot:TRPV2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TRPV2_HUMAN
neXtProt	NX_Q9Y5S1	http://www.nextprot.org/db/entry/NX_Q9Y5S1
octanol	swissprot:TRPV2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TRPV2_HUMAN
pepcoil	swissprot:TRPV2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TRPV2_HUMAN
pepdigest	swissprot:TRPV2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TRPV2_HUMAN
pepinfo	swissprot:TRPV2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TRPV2_HUMAN
pepnet	swissprot:TRPV2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TRPV2_HUMAN
pepstats	swissprot:TRPV2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TRPV2_HUMAN
pepwheel	swissprot:TRPV2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TRPV2_HUMAN
pepwindow	swissprot:TRPV2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TRPV2_HUMAN
sigcleave	swissprot:TRPV2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TRPV2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S29A1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99808-1; Sequence=Displayed; Name=2; IsoId=Q99808-2; Sequence=VSP_056579; Note=No experimental confirmation available.; 
# AltName	S29A1_HUMAN	Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter
# AltName	S29A1_HUMAN	Nucleoside transporter, es-type
# AltName	S29A1_HUMAN	Solute carrier family 29 member 1
# BIOPHYSICOCHEMICAL PROPERTIES	Kinetic parameters: KM=0.62 mM for adenosine {ECO	0000269|PubMed:12527552}; Note=Vmax for adenosine uptake is about the same for SLC29A1 and SLC29A2.; 
# BioGrid	108344	21
# CCDS	CCDS4908	-. [Q99808-1]
# ChiTaRS	SLC29A1	human
# DrugBank	DB00441	Gemcitabine
# DrugBank	DB00544	Fluorouracil
# DrugBank	DB00642	Pemetrexed
# DrugBank	DB00811	Ribavirin
# DrugBank	DB00898	Ethanol
# DrugBank	DB00900	Didanosine
# DrugBank	DB00943	Zalcitabine
# DrugBank	DB00987	Cytarabine
# DrugBank	DB01033	Mercaptopurine
# DrugBank	DB01073	Fludarabine
# Ensembl	ENST00000371708	ENSP00000360773; ENSG00000112759. [Q99808-1]
# Ensembl	ENST00000371713	ENSP00000360778; ENSG00000112759. [Q99808-1]
# Ensembl	ENST00000371724	ENSP00000360789; ENSG00000112759. [Q99808-1]
# Ensembl	ENST00000371731	ENSP00000360796; ENSG00000112759. [Q99808-1]
# Ensembl	ENST00000371740	ENSP00000360805; ENSG00000112759. [Q99808-1]
# Ensembl	ENST00000371755	ENSP00000360820; ENSG00000112759. [Q99808-1]
# Ensembl	ENST00000393841	ENSP00000377424; ENSG00000112759. [Q99808-1]
# Ensembl	ENST00000393844	ENSP00000377427; ENSG00000112759. [Q99808-1]
# Ensembl	ENST00000427851	ENSP00000392668; ENSG00000112759. [Q99808-1]
# FUNCTION	S29A1_HUMAN	Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs). 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016323	basolateral plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_component	GO:0098794	postsynapse; IEA:GOC.
# GO_function	GO:0005337	nucleoside transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0006139	nucleobase-containing compound metabolic process; TAS:ProtInc.
# GO_process	GO:0007595	lactation; IEA:Ensembl.
# GO_process	GO:0015858	nucleoside transport; IDA:UniProtKB.
# GO_process	GO:0015862	uridine transport; IEA:Ensembl.
# GO_process	GO:0030431	sleep; IEA:Ensembl.
# GO_process	GO:0060079	excitatory postsynaptic potential; IEA:Ensembl.
# GO_process	GO:0071333	cellular response to glucose stimulus; IEA:Ensembl.
# GO_process	GO:0071456	cellular response to hypoxia; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0042592	homeostatic process
# Genevisible	Q99808	HS
# HGNC	HGNC:11003	SLC29A1
# IntAct	Q99808	4
# InterPro	IPR002259	Eqnu_transpt
# InterPro	IPR020846	MFS_dom
# InterPro	IPR030195	ENT1
# KEGG_Brite	ko02001	Solute carrier family
# MIM	602193	gene
# Organism	S29A1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10332	PTHR10332; 2
# PANTHER	PTHR10332:SF9	PTHR10332:SF9; 2
# PIRSF	PIRSF016379	ENT
# PRINTS	PR01130	DERENTRNSPRT
# PTM	S29A1_HUMAN	Glycosylated. {ECO 0000269|PubMed 19349973}. 
# Pfam	PF01733	Nucleoside_tran
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-83936	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
# RecName	S29A1_HUMAN	Equilibrative nucleoside transporter 1
# RefSeq	NP_001071643	NM_001078175.2. [Q99808-1]
# RefSeq	NP_001071645	NM_001078177.1. [Q99808-1]
# RefSeq	NP_001291391	NM_001304462.1. [Q99808-2]
# RefSeq	NP_001291392	NM_001304463.1
# RefSeq	NP_001291394	NM_001304465.1
# RefSeq	NP_001291395	NM_001304466.1
# RefSeq	XP_005248935	XM_005248878.3. [Q99808-1]
# RefSeq	XP_005248936	XM_005248879.3. [Q99808-1]
# RefSeq	XP_005248937	XM_005248880.3. [Q99808-1]
# RefSeq	XP_005248938	XM_005248881.3. [Q99808-1]
# RefSeq	XP_005248939	XM_005248882.3. [Q99808-1]
# SIMILARITY	Belongs to the SLC29A/ENT transporter (TC 2.A.57) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S29A1_HUMAN	Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Predominantly localized in the basolateral membrane in polarized MDCK cells. 
# SUBUNIT	Identified in a complex with STOM. {ECO:0000269|PubMed	23219802}. 
# SUPFAM	SSF103473	SSF103473; 3
# TCDB	2.A.57.1	the equilibrative nucleoside transporter (ent) family
# TIGRFAMs	TIGR00939	2a57
# TISSUE SPECIFICITY	S29A1_HUMAN	Detected in erythrocytes (at protein level). Expressed in heart, brain, mammary gland, erythrocytes and placenta, and also in fetal liver and spleen. {ECO 0000269|PubMed 12527552, ECO 0000269|PubMed 23219802}. 
# UCSC	uc003owu	human. [Q99808-1]
# eggNOG	ENOG410Y3MT	LUCA
# eggNOG	KOG1479	Eukaryota
BLAST	swissprot:S29A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S29A1_HUMAN
COXPRESdb	2030	http://coxpresdb.jp/data/gene/2030.shtml
CleanEx	HS_SLC29A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC29A1
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1007/s002800050040	http://dx.doi.org/10.1007/s002800050040
DOI	10.1016/j.bbamem.2012.11.030	http://dx.doi.org/10.1016/j.bbamem.2012.11.030
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/nbt.1532	http://dx.doi.org/10.1038/nbt.1532
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/nm0197-89	http://dx.doi.org/10.1038/nm0197-89
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1093/nar/gkf564	http://dx.doi.org/10.1093/nar/gkf564
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DrugBank	DB00441	http://www.drugbank.ca/drugs/DB00441
DrugBank	DB00544	http://www.drugbank.ca/drugs/DB00544
DrugBank	DB00642	http://www.drugbank.ca/drugs/DB00642
DrugBank	DB00811	http://www.drugbank.ca/drugs/DB00811
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB00900	http://www.drugbank.ca/drugs/DB00900
DrugBank	DB00943	http://www.drugbank.ca/drugs/DB00943
DrugBank	DB00987	http://www.drugbank.ca/drugs/DB00987
DrugBank	DB01033	http://www.drugbank.ca/drugs/DB01033
DrugBank	DB01073	http://www.drugbank.ca/drugs/DB01073
EMBL	AF079117	http://www.ebi.ac.uk/ena/data/view/AF079117
EMBL	AF190884	http://www.ebi.ac.uk/ena/data/view/AF190884
EMBL	AF495730	http://www.ebi.ac.uk/ena/data/view/AF495730
EMBL	AK090491	http://www.ebi.ac.uk/ena/data/view/AK090491
EMBL	AK090615	http://www.ebi.ac.uk/ena/data/view/AK090615
EMBL	AL139392	http://www.ebi.ac.uk/ena/data/view/AL139392
EMBL	BC001382	http://www.ebi.ac.uk/ena/data/view/BC001382
EMBL	BC008954	http://www.ebi.ac.uk/ena/data/view/BC008954
EMBL	CH471081	http://www.ebi.ac.uk/ena/data/view/CH471081
EMBL	U81375	http://www.ebi.ac.uk/ena/data/view/U81375
Ensembl	ENST00000371708	http://www.ensembl.org/id/ENST00000371708
Ensembl	ENST00000371713	http://www.ensembl.org/id/ENST00000371713
Ensembl	ENST00000371724	http://www.ensembl.org/id/ENST00000371724
Ensembl	ENST00000371731	http://www.ensembl.org/id/ENST00000371731
Ensembl	ENST00000371740	http://www.ensembl.org/id/ENST00000371740
Ensembl	ENST00000371755	http://www.ensembl.org/id/ENST00000371755
Ensembl	ENST00000393841	http://www.ensembl.org/id/ENST00000393841
Ensembl	ENST00000393844	http://www.ensembl.org/id/ENST00000393844
Ensembl	ENST00000427851	http://www.ensembl.org/id/ENST00000427851
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0098794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098794
GO_function	GO:0005337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005337
GO_process	GO:0006139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006139
GO_process	GO:0007595	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007595
GO_process	GO:0015858	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015858
GO_process	GO:0015862	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015862
GO_process	GO:0030431	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030431
GO_process	GO:0060079	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060079
GO_process	GO:0071333	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071333
GO_process	GO:0071456	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071456
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GeneCards	SLC29A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC29A1
GeneID	2030	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2030
GeneTree	ENSGT00390000002232	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002232
HGNC	HGNC:11003	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11003
HOGENOM	HOG000007684	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007684&db=HOGENOM6
HOVERGEN	HBG074626	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG074626&db=HOVERGEN
HPA	HPA012383	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA012383
HPA	HPA012384	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA012384
InParanoid	Q99808	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q99808
IntAct	Q99808	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q99808*
InterPro	IPR002259	http://www.ebi.ac.uk/interpro/entry/IPR002259
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
InterPro	IPR030195	http://www.ebi.ac.uk/interpro/entry/IPR030195
Jabion	2030	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2030
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:2030	http://www.genome.jp/dbget-bin/www_bget?hsa:2030
KEGG_Orthology	KO:K15014	http://www.genome.jp/dbget-bin/www_bget?KO:K15014
MIM	602193	http://www.ncbi.nlm.nih.gov/omim/602193
MINT	MINT-1034227	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1034227
OMA	STWERYF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=STWERYF
OrthoDB	EOG091G09WB	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G09WB
PANTHER	PTHR10332	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10332
PANTHER	PTHR10332:SF9	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10332:SF9
PRINTS	PR01130	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01130
PSORT	swissprot:S29A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S29A1_HUMAN
PSORT-B	swissprot:S29A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S29A1_HUMAN
PSORT2	swissprot:S29A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S29A1_HUMAN
Pfam	PF01733	http://pfam.xfam.org/family/PF01733
PharmGKB	PA154	http://www.pharmgkb.org/do/serve?objId=PA154&objCls=Gene
Phobius	swissprot:S29A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S29A1_HUMAN
PhylomeDB	Q99808	http://phylomedb.org/?seqid=Q99808
ProteinModelPortal	Q99808	http://www.proteinmodelportal.org/query/uniprot/Q99808
PubMed	10755314	http://www.ncbi.nlm.nih.gov/pubmed/10755314
PubMed	12384580	http://www.ncbi.nlm.nih.gov/pubmed/12384580
PubMed	12527552	http://www.ncbi.nlm.nih.gov/pubmed/12527552
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19349973	http://www.ncbi.nlm.nih.gov/pubmed/19349973
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	23219802	http://www.ncbi.nlm.nih.gov/pubmed/23219802
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	8986748	http://www.ncbi.nlm.nih.gov/pubmed/8986748
Reactome	R-HSA-83936	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-83936
RefSeq	NP_001071643	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001071643
RefSeq	NP_001071645	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001071645
RefSeq	NP_001291391	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001291391
RefSeq	NP_001291392	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001291392
RefSeq	NP_001291394	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001291394
RefSeq	NP_001291395	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001291395
RefSeq	XP_005248935	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005248935
RefSeq	XP_005248936	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005248936
RefSeq	XP_005248937	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005248937
RefSeq	XP_005248938	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005248938
RefSeq	XP_005248939	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005248939
SMR	Q99808	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q99808
STRING	9606.ENSP00000360773	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000360773&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.57.1	http://www.tcdb.org/search/result.php?tc=2.A.57.1
TIGRFAMs	TIGR00939	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00939
UCSC	uc003owu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003owu&org=rat
UniGene	Hs.25450	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.25450
UniProtKB	S29A1_HUMAN	http://www.uniprot.org/uniprot/S29A1_HUMAN
UniProtKB-AC	Q99808	http://www.uniprot.org/uniprot/Q99808
charge	swissprot:S29A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S29A1_HUMAN
eggNOG	ENOG410Y3MT	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y3MT
eggNOG	KOG1479	http://eggnogapi.embl.de/nog_data/html/tree/KOG1479
epestfind	swissprot:S29A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S29A1_HUMAN
garnier	swissprot:S29A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S29A1_HUMAN
helixturnhelix	swissprot:S29A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S29A1_HUMAN
hmoment	swissprot:S29A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S29A1_HUMAN
iep	swissprot:S29A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S29A1_HUMAN
inforesidue	swissprot:S29A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S29A1_HUMAN
neXtProt	NX_Q99808	http://www.nextprot.org/db/entry/NX_Q99808
octanol	swissprot:S29A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S29A1_HUMAN
pepcoil	swissprot:S29A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S29A1_HUMAN
pepdigest	swissprot:S29A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S29A1_HUMAN
pepinfo	swissprot:S29A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S29A1_HUMAN
pepnet	swissprot:S29A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S29A1_HUMAN
pepstats	swissprot:S29A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S29A1_HUMAN
pepwheel	swissprot:S29A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S29A1_HUMAN
pepwindow	swissprot:S29A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S29A1_HUMAN
sigcleave	swissprot:S29A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S29A1_HUMAN
## Database	ID	URL or Descriptions
# AltName	COX1_HUMAN	Cytochrome c oxidase polypeptide I
# BRENDA	1.9.3	2681
# BioGrid	110615	32
# CATALYTIC ACTIVITY	COX1_HUMAN	4 ferrocytochrome c + O(2) + 4 H(+) = 4 ferricytochrome c + 2 H(2)O. 
# CDD	cd01663	Cyt_c_Oxidase_I
# DISEASE	COX1_HUMAN	Colorectal cancer (CRC) [MIM 114500]  A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. {ECO 0000269|PubMed 16407113}. Note=The gene represented in this entry may be involved in disease pathogenesis. 
# DISEASE	COX1_HUMAN	Deafness, sensorineural, mitochondrial (DFNM) [MIM 500008]  A form of non-syndromic deafness with maternal inheritance. Affected individuals manifest progressive, postlingual, sensorineural hearing loss involving high frequencies. {ECO 0000269|PubMed 10577941}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	COX1_HUMAN	Leber hereditary optic neuropathy (LHON) [MIM 535000]  A maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes. {ECO 0000269|PubMed 1322638}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	COX1_HUMAN	Mitochondrial complex IV deficiency (MT-C4D) [MIM 220110]  A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, exercise intolerance, developmental delay, delayed motor development and mental retardation. Some affected individuals manifest a fatal hypertrophic cardiomyopathy resulting in neonatal death. A subset of patients manifest Leigh syndrome. {ECO 0000269|PubMed 12140182, ECO 0000269|PubMed 16284789}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	COX1_HUMAN	Note=MT-CO1 may play a role in the pathogenesis of acquired idiopathic sideroblastic anemia, a disease characterized by inadequate formation of heme and excessive accumulation of iron in mitochondria. Mitochondrial iron overload may be attributable to mutations of mitochondrial DNA because these can cause respiratory chain dysfunction, thereby impairing reduction of ferric iron to ferrous iron. The reduced form of iron is essential to the last step of mitochondrial heme biosynthesis. {ECO 0000269|PubMed 9389715, ECO 0000269|PubMed 9851701}. 
# DISEASE	COX1_HUMAN	Recurrent myoglobinuria mitochondrial (RM-MT) [MIM 550500]  Recurrent myoglobinuria is characterized by recurrent attacks of rhabdomyolysis (necrosis or disintegration of skeletal muscle) associated with muscle pain and weakness, and followed by excretion of myoglobin in the urine. {ECO 0000269|PubMed 10980727}. Note=The gene represented in this entry may be involved in disease pathogenesis. 
# DrugBank	DB02659	Cholic Acid
# Ensembl	ENST00000361624	ENSP00000354499; ENSG00000198804
# ExpressionAtlas	P00395	baseline and differential
# FUNCTION	COX1_HUMAN	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. 
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0005751	mitochondrial respiratory chain complex IV; IEA:Ensembl.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0045277	respiratory chain complex IV; IDA:UniProtKB.
# GO_function	GO:0004129	cytochrome-c oxidase activity; IEA:UniProtKB-EC.
# GO_function	GO:0005506	iron ion binding; IEA:InterPro.
# GO_function	GO:0020037	heme binding; IEA:InterPro.
# GO_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen; TAS:Reactome.
# GO_process	GO:0006979	response to oxidative stress; IEA:Ensembl.
# GO_process	GO:0007568	aging; IEA:Ensembl.
# GO_process	GO:0009060	aerobic respiration; IEA:InterPro.
# GO_process	GO:0021549	cerebellum development; IEA:Ensembl.
# GO_process	GO:0046688	response to copper ion; IEA:Ensembl.
# GO_process	GO:0051602	response to electrical stimulus; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007568	aging
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# Gene3D	1.20.210.10	-; 1.
# Genevisible	P00395	HS
# HGNC	HGNC:7419	MT-CO1
# INTERACTION	COX1_HUMAN	Q9Y2R0 COA3; NbExp=11; IntAct=EBI-2117234, EBI-6570446; P13073 COX4I1; NbExp=2; IntAct=EBI-2117234, EBI-1056574; Q9BVV7 TIMM21; NbExp=3; IntAct=EBI-2117234, EBI-6570759; 
# IntAct	P00395	13
# InterPro	IPR000883	COX1
# InterPro	IPR023615	Cyt_c_Oxase_su1_BS
# InterPro	IPR023616	Cyt_c_oxase-like_su1_dom
# InterPro	IPR033944	Cyt_c_oxase_su1_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Disease	H00068	[Neurodegenerative disease] Leber hereditary optic atrophy (LHON)
# KEGG_Disease	H01368:[Inherited metabolic disease; Mitochondrial disease] Leber Hereditary Optic Neuropathy (LHON) [DS	H00068]
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	114500	phenotype
# MIM	220110	phenotype
# MIM	500008	phenotype
# MIM	516030	gene
# MIM	535000	phenotype
# MIM	550500	phenotype
# Organism	COX1_HUMAN	Homo sapiens (Human)
# Orphanet	104	Leber hereditary optic neuropathy
# Orphanet	168609	Mitochondrial non-syndromic sensorineural deafness with susceptibility to aminoglycoside exposure
# Orphanet	254905	Isolated cytochrome C oxidase deficiency
# Orphanet	255210	Maternally-inherited Leigh syndrome
# Orphanet	550	MELAS
# Orphanet	90641	Mitochondrial non-syndromic sensorineural deafness
# Orphanet	99845	Genetic recurrent myoglobinuria
# PANTHER	PTHR10422	PTHR10422
# PATHWAY	COX1_HUMAN	Energy metabolism; oxidative phosphorylation. 
# PIR	A00463	ODHU1
# PRINTS	PR01165	CYCOXIDASEI
# PROSITE	PS00077	COX1_CUB
# PROSITE	PS50855	COX1
# Pfam	PF00115	COX1
# Proteomes	UP000005640	Mitochondrion
# Reactome	R-HSA-5628897	TP53 Regulates Metabolic Genes
# Reactome	R-HSA-611105	Respiratory electron transport
# RecName	COX1_HUMAN	Cytochrome c oxidase subunit 1
# RefSeq	YP_003024028	NC_012920.1
# SIMILARITY	Belongs to the heme-copper respiratory oxidase family. {ECO	0000305}.
# SUBCELLULAR LOCATION	COX1_HUMAN	Mitochondrion inner membrane; Multi-pass membrane protein. 
# SUBUNIT	As a newly synthesized protein, rapidly incorporates into a multi-subunit assembly intermediate in the inner membrane, called MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase) complex, whose core components are COA3/MITRAC12 and COX14. Within the MITRAC complex, interacts with COA3 and with SMIM20/MITRAC7; the interaction with SMIM20 stabilizes the newly synthesized MT-CO1 and prevents its premature turnover. {ECO:0000269|PubMed	26321642}. 
# SUPFAM	SSF81442	SSF81442
# TCDB	3.D.4.11	the proton-translocating cytochrome oxidase (cox) superfamily
# eggNOG	COG0843	LUCA
# eggNOG	KOG4769	Eukaryota
BLAST	swissprot:COX1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:COX1_HUMAN
BioCyc	ZFISH:HS00026-MONOMER	http://biocyc.org/getid?id=ZFISH:HS00026-MONOMER
COG	COG0843	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0843
COXPRESdb	4512	http://coxpresdb.jp/data/gene/4512.shtml
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1007/BF00206061	http://dx.doi.org/10.1007/BF00206061
DOI	10.1007/s00414-004-0427-6	http://dx.doi.org/10.1007/s00414-004-0427-6
DOI	10.1007/s10048-005-0015-z	http://dx.doi.org/10.1007/s10048-005-0015-z
DOI	10.1016/0022-2836(80)90196-5	http://dx.doi.org/10.1016/0022-2836(80)90196-5
DOI	10.1016/j.celrep.2015.08.009	http://dx.doi.org/10.1016/j.celrep.2015.08.009
DOI	10.1038/290457a0	http://dx.doi.org/10.1038/290457a0
DOI	10.1038/35047064	http://dx.doi.org/10.1038/35047064
DOI	10.1046/j.1432-1327.1998.2580132.x	http://dx.doi.org/10.1046/j.1432-1327.1998.2580132.x
DOI	10.1073/pnas.0505903103	http://dx.doi.org/10.1073/pnas.0505903103
DOI	10.1073/pnas.0811450106	http://dx.doi.org/10.1073/pnas.0811450106
DOI	10.1073/pnas.92.2.532	http://dx.doi.org/10.1073/pnas.92.2.532
DOI	10.1086/302658	http://dx.doi.org/10.1086/302658
DOI	10.1093/hmg/11.16.1797	http://dx.doi.org/10.1093/hmg/11.16.1797
DOI	10.1093/molbev/msg230	http://dx.doi.org/10.1093/molbev/msg230
DOI	10.1101/gr.686603	http://dx.doi.org/10.1101/gr.686603
DOI	10.1212/WNL.55.5.644	http://dx.doi.org/10.1212/WNL.55.5.644
DrugBank	DB02659	http://www.drugbank.ca/drugs/DB02659
EC_number	EC:1.9.3.1	http://www.genome.jp/dbget-bin/www_bget?EC:1.9.3.1
EMBL	AF346963	http://www.ebi.ac.uk/ena/data/view/AF346963
EMBL	AF346964	http://www.ebi.ac.uk/ena/data/view/AF346964
EMBL	AF346965	http://www.ebi.ac.uk/ena/data/view/AF346965
EMBL	AF346966	http://www.ebi.ac.uk/ena/data/view/AF346966
EMBL	AF346967	http://www.ebi.ac.uk/ena/data/view/AF346967
EMBL	AF346970	http://www.ebi.ac.uk/ena/data/view/AF346970
EMBL	AF346971	http://www.ebi.ac.uk/ena/data/view/AF346971
EMBL	AF346972	http://www.ebi.ac.uk/ena/data/view/AF346972
EMBL	AF346973	http://www.ebi.ac.uk/ena/data/view/AF346973
EMBL	AF346974	http://www.ebi.ac.uk/ena/data/view/AF346974
EMBL	AF346975	http://www.ebi.ac.uk/ena/data/view/AF346975
EMBL	AF346976	http://www.ebi.ac.uk/ena/data/view/AF346976
EMBL	AF346977	http://www.ebi.ac.uk/ena/data/view/AF346977
EMBL	AF346978	http://www.ebi.ac.uk/ena/data/view/AF346978
EMBL	AF346979	http://www.ebi.ac.uk/ena/data/view/AF346979
EMBL	AF346980	http://www.ebi.ac.uk/ena/data/view/AF346980
EMBL	AF346981	http://www.ebi.ac.uk/ena/data/view/AF346981
EMBL	AF346982	http://www.ebi.ac.uk/ena/data/view/AF346982
EMBL	AF346983	http://www.ebi.ac.uk/ena/data/view/AF346983
EMBL	AF346984	http://www.ebi.ac.uk/ena/data/view/AF346984
EMBL	AF346988	http://www.ebi.ac.uk/ena/data/view/AF346988
EMBL	AF346989	http://www.ebi.ac.uk/ena/data/view/AF346989
EMBL	AF346990	http://www.ebi.ac.uk/ena/data/view/AF346990
EMBL	AF346991	http://www.ebi.ac.uk/ena/data/view/AF346991
EMBL	AF346993	http://www.ebi.ac.uk/ena/data/view/AF346993
EMBL	AF346994	http://www.ebi.ac.uk/ena/data/view/AF346994
EMBL	AF346995	http://www.ebi.ac.uk/ena/data/view/AF346995
EMBL	AF346998	http://www.ebi.ac.uk/ena/data/view/AF346998
EMBL	AF347000	http://www.ebi.ac.uk/ena/data/view/AF347000
EMBL	AF347001	http://www.ebi.ac.uk/ena/data/view/AF347001
EMBL	AF347003	http://www.ebi.ac.uk/ena/data/view/AF347003
EMBL	AF347004	http://www.ebi.ac.uk/ena/data/view/AF347004
EMBL	AF347007	http://www.ebi.ac.uk/ena/data/view/AF347007
EMBL	AF347010	http://www.ebi.ac.uk/ena/data/view/AF347010
EMBL	AF347011	http://www.ebi.ac.uk/ena/data/view/AF347011
EMBL	AF347012	http://www.ebi.ac.uk/ena/data/view/AF347012
EMBL	AF347013	http://www.ebi.ac.uk/ena/data/view/AF347013
EMBL	AF347014	http://www.ebi.ac.uk/ena/data/view/AF347014
EMBL	AF347015	http://www.ebi.ac.uk/ena/data/view/AF347015
EMBL	AY289051	http://www.ebi.ac.uk/ena/data/view/AY289051
EMBL	AY289052	http://www.ebi.ac.uk/ena/data/view/AY289052
EMBL	AY289053	http://www.ebi.ac.uk/ena/data/view/AY289053
EMBL	AY289055	http://www.ebi.ac.uk/ena/data/view/AY289055
EMBL	AY289056	http://www.ebi.ac.uk/ena/data/view/AY289056
EMBL	AY289057	http://www.ebi.ac.uk/ena/data/view/AY289057
EMBL	AY289058	http://www.ebi.ac.uk/ena/data/view/AY289058
EMBL	AY289059	http://www.ebi.ac.uk/ena/data/view/AY289059
EMBL	AY289060	http://www.ebi.ac.uk/ena/data/view/AY289060
EMBL	AY289061	http://www.ebi.ac.uk/ena/data/view/AY289061
EMBL	AY289062	http://www.ebi.ac.uk/ena/data/view/AY289062
EMBL	AY289064	http://www.ebi.ac.uk/ena/data/view/AY289064
EMBL	AY289065	http://www.ebi.ac.uk/ena/data/view/AY289065
EMBL	AY289066	http://www.ebi.ac.uk/ena/data/view/AY289066
EMBL	AY289067	http://www.ebi.ac.uk/ena/data/view/AY289067
EMBL	AY289068	http://www.ebi.ac.uk/ena/data/view/AY289068
EMBL	AY289069	http://www.ebi.ac.uk/ena/data/view/AY289069
EMBL	AY289070	http://www.ebi.ac.uk/ena/data/view/AY289070
EMBL	AY289071	http://www.ebi.ac.uk/ena/data/view/AY289071
EMBL	AY289073	http://www.ebi.ac.uk/ena/data/view/AY289073
EMBL	AY289074	http://www.ebi.ac.uk/ena/data/view/AY289074
EMBL	AY289075	http://www.ebi.ac.uk/ena/data/view/AY289075
EMBL	AY289076	http://www.ebi.ac.uk/ena/data/view/AY289076
EMBL	AY289077	http://www.ebi.ac.uk/ena/data/view/AY289077
EMBL	AY289078	http://www.ebi.ac.uk/ena/data/view/AY289078
EMBL	AY289079	http://www.ebi.ac.uk/ena/data/view/AY289079
EMBL	AY289080	http://www.ebi.ac.uk/ena/data/view/AY289080
EMBL	AY289081	http://www.ebi.ac.uk/ena/data/view/AY289081
EMBL	AY289082	http://www.ebi.ac.uk/ena/data/view/AY289082
EMBL	AY289083	http://www.ebi.ac.uk/ena/data/view/AY289083
EMBL	AY289084	http://www.ebi.ac.uk/ena/data/view/AY289084
EMBL	AY289085	http://www.ebi.ac.uk/ena/data/view/AY289085
EMBL	AY289086	http://www.ebi.ac.uk/ena/data/view/AY289086
EMBL	AY289088	http://www.ebi.ac.uk/ena/data/view/AY289088
EMBL	AY289089	http://www.ebi.ac.uk/ena/data/view/AY289089
EMBL	AY289090	http://www.ebi.ac.uk/ena/data/view/AY289090
EMBL	AY289092	http://www.ebi.ac.uk/ena/data/view/AY289092
EMBL	AY289093	http://www.ebi.ac.uk/ena/data/view/AY289093
EMBL	AY289094	http://www.ebi.ac.uk/ena/data/view/AY289094
EMBL	AY289095	http://www.ebi.ac.uk/ena/data/view/AY289095
EMBL	AY289096	http://www.ebi.ac.uk/ena/data/view/AY289096
EMBL	AY289097	http://www.ebi.ac.uk/ena/data/view/AY289097
EMBL	AY289098	http://www.ebi.ac.uk/ena/data/view/AY289098
EMBL	AY289099	http://www.ebi.ac.uk/ena/data/view/AY289099
EMBL	AY289100	http://www.ebi.ac.uk/ena/data/view/AY289100
EMBL	AY289101	http://www.ebi.ac.uk/ena/data/view/AY289101
EMBL	AY289102	http://www.ebi.ac.uk/ena/data/view/AY289102
EMBL	AY339402	http://www.ebi.ac.uk/ena/data/view/AY339402
EMBL	AY339403	http://www.ebi.ac.uk/ena/data/view/AY339403
EMBL	AY339404	http://www.ebi.ac.uk/ena/data/view/AY339404
EMBL	AY339405	http://www.ebi.ac.uk/ena/data/view/AY339405
EMBL	AY339406	http://www.ebi.ac.uk/ena/data/view/AY339406
EMBL	AY339407	http://www.ebi.ac.uk/ena/data/view/AY339407
EMBL	AY339408	http://www.ebi.ac.uk/ena/data/view/AY339408
EMBL	AY339409	http://www.ebi.ac.uk/ena/data/view/AY339409
EMBL	AY339410	http://www.ebi.ac.uk/ena/data/view/AY339410
EMBL	AY339411	http://www.ebi.ac.uk/ena/data/view/AY339411
EMBL	AY339412	http://www.ebi.ac.uk/ena/data/view/AY339412
EMBL	AY339421	http://www.ebi.ac.uk/ena/data/view/AY339421
EMBL	AY339422	http://www.ebi.ac.uk/ena/data/view/AY339422
EMBL	AY339423	http://www.ebi.ac.uk/ena/data/view/AY339423
EMBL	AY339424	http://www.ebi.ac.uk/ena/data/view/AY339424
EMBL	AY339425	http://www.ebi.ac.uk/ena/data/view/AY339425
EMBL	AY339426	http://www.ebi.ac.uk/ena/data/view/AY339426
EMBL	AY339427	http://www.ebi.ac.uk/ena/data/view/AY339427
EMBL	AY339428	http://www.ebi.ac.uk/ena/data/view/AY339428
EMBL	AY339429	http://www.ebi.ac.uk/ena/data/view/AY339429
EMBL	AY339430	http://www.ebi.ac.uk/ena/data/view/AY339430
EMBL	AY339431	http://www.ebi.ac.uk/ena/data/view/AY339431
EMBL	AY339432	http://www.ebi.ac.uk/ena/data/view/AY339432
EMBL	AY339433	http://www.ebi.ac.uk/ena/data/view/AY339433
EMBL	AY339434	http://www.ebi.ac.uk/ena/data/view/AY339434
EMBL	AY339435	http://www.ebi.ac.uk/ena/data/view/AY339435
EMBL	AY339436	http://www.ebi.ac.uk/ena/data/view/AY339436
EMBL	AY339437	http://www.ebi.ac.uk/ena/data/view/AY339437
EMBL	AY339438	http://www.ebi.ac.uk/ena/data/view/AY339438
EMBL	AY339439	http://www.ebi.ac.uk/ena/data/view/AY339439
EMBL	AY339440	http://www.ebi.ac.uk/ena/data/view/AY339440
EMBL	AY339441	http://www.ebi.ac.uk/ena/data/view/AY339441
EMBL	AY339442	http://www.ebi.ac.uk/ena/data/view/AY339442
EMBL	AY339443	http://www.ebi.ac.uk/ena/data/view/AY339443
EMBL	AY339444	http://www.ebi.ac.uk/ena/data/view/AY339444
EMBL	AY339445	http://www.ebi.ac.uk/ena/data/view/AY339445
EMBL	AY339451	http://www.ebi.ac.uk/ena/data/view/AY339451
EMBL	AY339452	http://www.ebi.ac.uk/ena/data/view/AY339452
EMBL	AY339453	http://www.ebi.ac.uk/ena/data/view/AY339453
EMBL	AY339454	http://www.ebi.ac.uk/ena/data/view/AY339454
EMBL	AY339455	http://www.ebi.ac.uk/ena/data/view/AY339455
EMBL	AY339456	http://www.ebi.ac.uk/ena/data/view/AY339456
EMBL	AY339457	http://www.ebi.ac.uk/ena/data/view/AY339457
EMBL	AY339458	http://www.ebi.ac.uk/ena/data/view/AY339458
EMBL	AY339459	http://www.ebi.ac.uk/ena/data/view/AY339459
EMBL	AY339460	http://www.ebi.ac.uk/ena/data/view/AY339460
EMBL	AY339461	http://www.ebi.ac.uk/ena/data/view/AY339461
EMBL	AY339462	http://www.ebi.ac.uk/ena/data/view/AY339462
EMBL	AY339463	http://www.ebi.ac.uk/ena/data/view/AY339463
EMBL	AY339464	http://www.ebi.ac.uk/ena/data/view/AY339464
EMBL	AY339465	http://www.ebi.ac.uk/ena/data/view/AY339465
EMBL	AY339466	http://www.ebi.ac.uk/ena/data/view/AY339466
EMBL	AY339467	http://www.ebi.ac.uk/ena/data/view/AY339467
EMBL	AY339468	http://www.ebi.ac.uk/ena/data/view/AY339468
EMBL	AY339469	http://www.ebi.ac.uk/ena/data/view/AY339469
EMBL	AY339470	http://www.ebi.ac.uk/ena/data/view/AY339470
EMBL	AY339471	http://www.ebi.ac.uk/ena/data/view/AY339471
EMBL	AY339472	http://www.ebi.ac.uk/ena/data/view/AY339472
EMBL	AY339473	http://www.ebi.ac.uk/ena/data/view/AY339473
EMBL	AY339474	http://www.ebi.ac.uk/ena/data/view/AY339474
EMBL	AY339475	http://www.ebi.ac.uk/ena/data/view/AY339475
EMBL	AY339476	http://www.ebi.ac.uk/ena/data/view/AY339476
EMBL	AY339477	http://www.ebi.ac.uk/ena/data/view/AY339477
EMBL	AY339478	http://www.ebi.ac.uk/ena/data/view/AY339478
EMBL	AY339479	http://www.ebi.ac.uk/ena/data/view/AY339479
EMBL	AY339480	http://www.ebi.ac.uk/ena/data/view/AY339480
EMBL	AY339481	http://www.ebi.ac.uk/ena/data/view/AY339481
EMBL	AY339482	http://www.ebi.ac.uk/ena/data/view/AY339482
EMBL	AY339483	http://www.ebi.ac.uk/ena/data/view/AY339483
EMBL	AY339484	http://www.ebi.ac.uk/ena/data/view/AY339484
EMBL	AY339485	http://www.ebi.ac.uk/ena/data/view/AY339485
EMBL	AY339486	http://www.ebi.ac.uk/ena/data/view/AY339486
EMBL	AY339487	http://www.ebi.ac.uk/ena/data/view/AY339487
EMBL	AY339488	http://www.ebi.ac.uk/ena/data/view/AY339488
EMBL	AY339489	http://www.ebi.ac.uk/ena/data/view/AY339489
EMBL	AY339490	http://www.ebi.ac.uk/ena/data/view/AY339490
EMBL	AY339491	http://www.ebi.ac.uk/ena/data/view/AY339491
EMBL	AY339492	http://www.ebi.ac.uk/ena/data/view/AY339492
EMBL	AY339493	http://www.ebi.ac.uk/ena/data/view/AY339493
EMBL	AY339494	http://www.ebi.ac.uk/ena/data/view/AY339494
EMBL	AY339495	http://www.ebi.ac.uk/ena/data/view/AY339495
EMBL	AY339496	http://www.ebi.ac.uk/ena/data/view/AY339496
EMBL	AY339497	http://www.ebi.ac.uk/ena/data/view/AY339497
EMBL	AY339498	http://www.ebi.ac.uk/ena/data/view/AY339498
EMBL	AY339499	http://www.ebi.ac.uk/ena/data/view/AY339499
EMBL	AY339500	http://www.ebi.ac.uk/ena/data/view/AY339500
EMBL	AY339501	http://www.ebi.ac.uk/ena/data/view/AY339501
EMBL	AY339502	http://www.ebi.ac.uk/ena/data/view/AY339502
EMBL	AY339503	http://www.ebi.ac.uk/ena/data/view/AY339503
EMBL	AY339504	http://www.ebi.ac.uk/ena/data/view/AY339504
EMBL	AY339505	http://www.ebi.ac.uk/ena/data/view/AY339505
EMBL	AY339506	http://www.ebi.ac.uk/ena/data/view/AY339506
EMBL	AY339507	http://www.ebi.ac.uk/ena/data/view/AY339507
EMBL	AY339508	http://www.ebi.ac.uk/ena/data/view/AY339508
EMBL	AY339509	http://www.ebi.ac.uk/ena/data/view/AY339509
EMBL	AY339510	http://www.ebi.ac.uk/ena/data/view/AY339510
EMBL	AY339511	http://www.ebi.ac.uk/ena/data/view/AY339511
EMBL	AY339512	http://www.ebi.ac.uk/ena/data/view/AY339512
EMBL	AY339513	http://www.ebi.ac.uk/ena/data/view/AY339513
EMBL	AY339514	http://www.ebi.ac.uk/ena/data/view/AY339514
EMBL	AY339515	http://www.ebi.ac.uk/ena/data/view/AY339515
EMBL	AY339516	http://www.ebi.ac.uk/ena/data/view/AY339516
EMBL	AY339517	http://www.ebi.ac.uk/ena/data/view/AY339517
EMBL	AY339518	http://www.ebi.ac.uk/ena/data/view/AY339518
EMBL	AY339519	http://www.ebi.ac.uk/ena/data/view/AY339519
EMBL	AY339520	http://www.ebi.ac.uk/ena/data/view/AY339520
EMBL	AY339521	http://www.ebi.ac.uk/ena/data/view/AY339521
EMBL	AY339522	http://www.ebi.ac.uk/ena/data/view/AY339522
EMBL	AY339523	http://www.ebi.ac.uk/ena/data/view/AY339523
EMBL	AY339524	http://www.ebi.ac.uk/ena/data/view/AY339524
EMBL	AY339525	http://www.ebi.ac.uk/ena/data/view/AY339525
EMBL	AY339526	http://www.ebi.ac.uk/ena/data/view/AY339526
EMBL	AY339527	http://www.ebi.ac.uk/ena/data/view/AY339527
EMBL	AY339528	http://www.ebi.ac.uk/ena/data/view/AY339528
EMBL	AY339529	http://www.ebi.ac.uk/ena/data/view/AY339529
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EMBL	AY495312	http://www.ebi.ac.uk/ena/data/view/AY495312
EMBL	AY495313	http://www.ebi.ac.uk/ena/data/view/AY495313
EMBL	AY495314	http://www.ebi.ac.uk/ena/data/view/AY495314
EMBL	AY495315	http://www.ebi.ac.uk/ena/data/view/AY495315
EMBL	AY495316	http://www.ebi.ac.uk/ena/data/view/AY495316
EMBL	AY495317	http://www.ebi.ac.uk/ena/data/view/AY495317
EMBL	AY495318	http://www.ebi.ac.uk/ena/data/view/AY495318
EMBL	AY495319	http://www.ebi.ac.uk/ena/data/view/AY495319
EMBL	AY495320	http://www.ebi.ac.uk/ena/data/view/AY495320
EMBL	AY495322	http://www.ebi.ac.uk/ena/data/view/AY495322
EMBL	AY495323	http://www.ebi.ac.uk/ena/data/view/AY495323
EMBL	AY495324	http://www.ebi.ac.uk/ena/data/view/AY495324
EMBL	AY495325	http://www.ebi.ac.uk/ena/data/view/AY495325
EMBL	AY495326	http://www.ebi.ac.uk/ena/data/view/AY495326
EMBL	AY495327	http://www.ebi.ac.uk/ena/data/view/AY495327
EMBL	AY495328	http://www.ebi.ac.uk/ena/data/view/AY495328
EMBL	AY495329	http://www.ebi.ac.uk/ena/data/view/AY495329
EMBL	AY495330	http://www.ebi.ac.uk/ena/data/view/AY495330
EMBL	D38112	http://www.ebi.ac.uk/ena/data/view/D38112
EMBL	J01415	http://www.ebi.ac.uk/ena/data/view/J01415
EMBL	M10546	http://www.ebi.ac.uk/ena/data/view/M10546
EMBL	V00662	http://www.ebi.ac.uk/ena/data/view/V00662
ENZYME	1.9.3.1	http://enzyme.expasy.org/EC/1.9.3.1
Ensembl	ENST00000361624	http://www.ensembl.org/id/ENST00000361624
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005751	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005751
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0045277	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045277
GO_function	GO:0004129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004129
GO_function	GO:0005506	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506
GO_function	GO:0020037	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037
GO_process	GO:0006123	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006123
GO_process	GO:0006979	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979
GO_process	GO:0007568	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007568
GO_process	GO:0009060	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009060
GO_process	GO:0021549	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021549
GO_process	GO:0046688	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046688
GO_process	GO:0051602	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051602
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007568	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007568
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
Gene3D	1.20.210.10	http://www.cathdb.info/version/latest/superfamily/1.20.210.10
GeneCards	MT-CO1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=MT-CO1
GeneID	4512	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4512
GeneTree	ENSGT00390000001518	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000001518
HGNC	HGNC:7419	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:7419
HOVERGEN	HBG003841	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003841&db=HOVERGEN
HPA	CAB016241	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB016241
HPA	HPA069328	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA069328
InParanoid	P00395	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00395
IntAct	P00395	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00395*
IntEnz	1.9.3.1	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.9.3.1
InterPro	IPR000883	http://www.ebi.ac.uk/interpro/entry/IPR000883
InterPro	IPR023615	http://www.ebi.ac.uk/interpro/entry/IPR023615
InterPro	IPR023616	http://www.ebi.ac.uk/interpro/entry/IPR023616
InterPro	IPR033944	http://www.ebi.ac.uk/interpro/entry/IPR033944
Jabion	4512	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=4512
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Disease	H00068	http://www.genome.jp/dbget-bin/www_bget?H00068
KEGG_Disease	H01368	http://www.genome.jp/dbget-bin/www_bget?H01368
KEGG_Gene	hsa:4512	http://www.genome.jp/dbget-bin/www_bget?hsa:4512
KEGG_Orthology	KO:K02256	http://www.genome.jp/dbget-bin/www_bget?KO:K02256
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	114500	http://www.ncbi.nlm.nih.gov/omim/114500
MIM	220110	http://www.ncbi.nlm.nih.gov/omim/220110
MIM	500008	http://www.ncbi.nlm.nih.gov/omim/500008
MIM	516030	http://www.ncbi.nlm.nih.gov/omim/516030
MIM	535000	http://www.ncbi.nlm.nih.gov/omim/535000
MIM	550500	http://www.ncbi.nlm.nih.gov/omim/550500
MINT	MINT-4773455	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4773455
OMA	PYHTFEE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PYHTFEE
Orphanet	104	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=104
Orphanet	168609	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=168609
Orphanet	254905	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=254905
Orphanet	255210	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=255210
Orphanet	550	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=550
Orphanet	90641	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=90641
Orphanet	99845	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=99845
OrthoDB	EOG091G035B	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G035B
PANTHER	PTHR10422	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10422
PRINTS	PR01165	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01165
PROSITE	PS00077	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00077
PROSITE	PS50855	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50855
PSORT	swissprot:COX1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:COX1_HUMAN
PSORT-B	swissprot:COX1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:COX1_HUMAN
PSORT2	swissprot:COX1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:COX1_HUMAN
Pfam	PF00115	http://pfam.xfam.org/family/PF00115
PharmGKB	PA31225	http://www.pharmgkb.org/do/serve?objId=PA31225&objCls=Gene
Phobius	swissprot:COX1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:COX1_HUMAN
PhylomeDB	P00395	http://phylomedb.org/?seqid=P00395
ProteinModelPortal	P00395	http://www.proteinmodelportal.org/query/uniprot/P00395
PubMed	10577941	http://www.ncbi.nlm.nih.gov/pubmed/10577941
PubMed	10980727	http://www.ncbi.nlm.nih.gov/pubmed/10980727
PubMed	11130070	http://www.ncbi.nlm.nih.gov/pubmed/11130070
PubMed	12140182	http://www.ncbi.nlm.nih.gov/pubmed/12140182
PubMed	12840039	http://www.ncbi.nlm.nih.gov/pubmed/12840039
PubMed	12949126	http://www.ncbi.nlm.nih.gov/pubmed/12949126
PubMed	1322638	http://www.ncbi.nlm.nih.gov/pubmed/1322638
PubMed	14760490	http://www.ncbi.nlm.nih.gov/pubmed/14760490
PubMed	16284789	http://www.ncbi.nlm.nih.gov/pubmed/16284789
PubMed	16407113	http://www.ncbi.nlm.nih.gov/pubmed/16407113
PubMed	1757091	http://www.ncbi.nlm.nih.gov/pubmed/1757091
PubMed	19218458	http://www.ncbi.nlm.nih.gov/pubmed/19218458
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	26321642	http://www.ncbi.nlm.nih.gov/pubmed/26321642
PubMed	6260957	http://www.ncbi.nlm.nih.gov/pubmed/6260957
PubMed	7219534	http://www.ncbi.nlm.nih.gov/pubmed/7219534
PubMed	7530363	http://www.ncbi.nlm.nih.gov/pubmed/7530363
PubMed	9389715	http://www.ncbi.nlm.nih.gov/pubmed/9389715
PubMed	9851701	http://www.ncbi.nlm.nih.gov/pubmed/9851701
Reactome	R-HSA-5628897	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5628897
Reactome	R-HSA-611105	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-611105
RefSeq	YP_003024028	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_003024028
SMR	P00395	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00395
STRING	9606.ENSP00000354499	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000354499&targetmode=cogs
STRING	COG0843	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0843&targetmode=cogs
SUPFAM	SSF81442	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81442
TCDB	3.D.4.11	http://www.tcdb.org/search/result.php?tc=3.D.4.11
UniProtKB	COX1_HUMAN	http://www.uniprot.org/uniprot/COX1_HUMAN
UniProtKB-AC	P00395	http://www.uniprot.org/uniprot/P00395
charge	swissprot:COX1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:COX1_HUMAN
eggNOG	COG0843	http://eggnogapi.embl.de/nog_data/html/tree/COG0843
eggNOG	KOG4769	http://eggnogapi.embl.de/nog_data/html/tree/KOG4769
epestfind	swissprot:COX1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:COX1_HUMAN
garnier	swissprot:COX1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:COX1_HUMAN
helixturnhelix	swissprot:COX1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:COX1_HUMAN
hmoment	swissprot:COX1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:COX1_HUMAN
iep	swissprot:COX1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:COX1_HUMAN
inforesidue	swissprot:COX1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:COX1_HUMAN
neXtProt	NX_P00395	http://www.nextprot.org/db/entry/NX_P00395
octanol	swissprot:COX1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:COX1_HUMAN
pepcoil	swissprot:COX1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:COX1_HUMAN
pepdigest	swissprot:COX1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:COX1_HUMAN
pepinfo	swissprot:COX1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:COX1_HUMAN
pepnet	swissprot:COX1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:COX1_HUMAN
pepstats	swissprot:COX1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:COX1_HUMAN
pepwheel	swissprot:COX1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:COX1_HUMAN
pepwindow	swissprot:COX1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:COX1_HUMAN
sigcleave	swissprot:COX1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:COX1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNN1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q92952-1; Sequence=Displayed; Name=2; IsoId=Q92952-2; Sequence=VSP_022501; 
# AltName	KCNN1_HUMAN	KCa2.1
# CCDS	CCDS67611	-. [Q92952-1]
# DrugBank	DB00721	Procaine
# DrugBank	DB01110	Miconazole
# Ensembl	ENST00000222249	ENSP00000476519; ENSG00000105642. [Q92952-1]
# ExpressionAtlas	Q92952	baseline and differential
# FUNCTION	KCNN1_HUMAN	Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity). {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008076	voltage-gated potassium channel complex; TAS:ProtInc.
# GO_component	GO:0043025	neuronal cell body; IBA:GO_Central.
# GO_function	GO:0005516	calmodulin binding; IBA:GO_Central.
# GO_function	GO:0015269	calcium-activated potassium channel activity; TAS:ProtInc.
# GO_function	GO:0016286	small conductance calcium-activated potassium channel activity; IBA:GO_Central.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# Genevisible	Q92952	HS
# HGNC	HGNC:6290	KCNN1
# InterPro	IPR004178	CaM-bd_dom
# InterPro	IPR013099	K_chnl_dom
# InterPro	IPR015449	K_chnl_Ca-activ_SK
# KEGG_Brite	ko04040	Ion channels
# MIM	602982	gene
# Organism	KCNN1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10153	PTHR10153
# PRINTS	PR01451	SKCHANNEL
# Pfam	PF02888	CaMBD
# Pfam	PF03530	SK_channel
# Pfam	PF07885	Ion_trans_2
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-1296052	Ca2+ activated K+ channels
# RecName	KCNN1_HUMAN	Small conductance calcium-activated potassium channel protein 1
# RefSeq	NP_002239	NM_002248.4. [Q92952-1]
# SIMILARITY	Belongs to the potassium channel KCNN family. KCa2.1/KCNN1 subfamily. {ECO	0000305}.
# SMART	SM01053	CaMBD
# SUBCELLULAR LOCATION	KCNN1_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity). {ECO	0000250}. 
# SUPFAM	SSF81327	SSF81327
# UCSC	uc002nht	human. [Q92952-1]
BLAST	swissprot:KCNN1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNN1_HUMAN
BioCyc	ZFISH:ENSG00000105642-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000105642-MONOMER
COXPRESdb	3780	http://coxpresdb.jp/data/gene/3780.shtml
CleanEx	HS_KCNN1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNN1
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.273.5282.1709	http://dx.doi.org/10.1126/science.273.5282.1709
DrugBank	DB00721	http://www.drugbank.ca/drugs/DB00721
DrugBank	DB01110	http://www.drugbank.ca/drugs/DB01110
EMBL	AB198191	http://www.ebi.ac.uk/ena/data/view/AB198191
EMBL	AF131940	http://www.ebi.ac.uk/ena/data/view/AF131940
EMBL	AF131941	http://www.ebi.ac.uk/ena/data/view/AF131941
EMBL	AF131942	http://www.ebi.ac.uk/ena/data/view/AF131942
EMBL	AF131943	http://www.ebi.ac.uk/ena/data/view/AF131943
EMBL	AF131944	http://www.ebi.ac.uk/ena/data/view/AF131944
EMBL	AF131945	http://www.ebi.ac.uk/ena/data/view/AF131945
EMBL	AF131946	http://www.ebi.ac.uk/ena/data/view/AF131946
EMBL	AF131947	http://www.ebi.ac.uk/ena/data/view/AF131947
EMBL	AF131948	http://www.ebi.ac.uk/ena/data/view/AF131948
EMBL	BC075037	http://www.ebi.ac.uk/ena/data/view/BC075037
EMBL	U69883	http://www.ebi.ac.uk/ena/data/view/U69883
Ensembl	ENST00000222249	http://www.ensembl.org/id/ENST00000222249
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_function	GO:0005516	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005516
GO_function	GO:0015269	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015269
GO_function	GO:0016286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016286
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GeneCards	KCNN1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNN1
GeneID	3780	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3780
GeneTree	ENSGT00500000044784	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00500000044784
HGNC	HGNC:6290	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6290
HOGENOM	HOG000276908	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276908&db=HOGENOM6
HOVERGEN	HBG052241	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052241&db=HOVERGEN
InParanoid	Q92952	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q92952
IntAct	Q92952	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q92952*
InterPro	IPR004178	http://www.ebi.ac.uk/interpro/entry/IPR004178
InterPro	IPR013099	http://www.ebi.ac.uk/interpro/entry/IPR013099
InterPro	IPR015449	http://www.ebi.ac.uk/interpro/entry/IPR015449
Jabion	3780	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3780
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3780	http://www.genome.jp/dbget-bin/www_bget?hsa:3780
KEGG_Orthology	KO:K04942	http://www.genome.jp/dbget-bin/www_bget?KO:K04942
MIM	602982	http://www.ncbi.nlm.nih.gov/omim/602982
OMA	IAMNTCK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IAMNTCK
PANTHER	PTHR10153	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10153
PRINTS	PR01451	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01451
PSORT	swissprot:KCNN1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNN1_HUMAN
PSORT-B	swissprot:KCNN1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNN1_HUMAN
PSORT2	swissprot:KCNN1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNN1_HUMAN
Pfam	PF02888	http://pfam.xfam.org/family/PF02888
Pfam	PF03530	http://pfam.xfam.org/family/PF03530
Pfam	PF07885	http://pfam.xfam.org/family/PF07885
PharmGKB	PA30070	http://www.pharmgkb.org/do/serve?objId=PA30070&objCls=Gene
Phobius	swissprot:KCNN1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNN1_HUMAN
PhylomeDB	Q92952	http://phylomedb.org/?seqid=Q92952
ProteinModelPortal	Q92952	http://www.proteinmodelportal.org/query/uniprot/Q92952
PubMed	10516439	http://www.ncbi.nlm.nih.gov/pubmed/10516439
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	8781233	http://www.ncbi.nlm.nih.gov/pubmed/8781233
Reactome	R-HSA-1296052	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296052
RefSeq	NP_002239	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002239
SMART	SM01053	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01053
SMR	Q92952	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q92952
SUPFAM	SSF81327	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81327
UCSC	uc002nht	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002nht&org=rat
UniGene	Hs.158173	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.158173
UniProtKB	KCNN1_HUMAN	http://www.uniprot.org/uniprot/KCNN1_HUMAN
UniProtKB-AC	Q92952	http://www.uniprot.org/uniprot/Q92952
charge	swissprot:KCNN1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNN1_HUMAN
epestfind	swissprot:KCNN1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNN1_HUMAN
garnier	swissprot:KCNN1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNN1_HUMAN
helixturnhelix	swissprot:KCNN1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNN1_HUMAN
hmoment	swissprot:KCNN1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNN1_HUMAN
iep	swissprot:KCNN1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNN1_HUMAN
inforesidue	swissprot:KCNN1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNN1_HUMAN
neXtProt	NX_Q92952	http://www.nextprot.org/db/entry/NX_Q92952
octanol	swissprot:KCNN1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNN1_HUMAN
pepcoil	swissprot:KCNN1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNN1_HUMAN
pepdigest	swissprot:KCNN1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNN1_HUMAN
pepinfo	swissprot:KCNN1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNN1_HUMAN
pepnet	swissprot:KCNN1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNN1_HUMAN
pepstats	swissprot:KCNN1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNN1_HUMAN
pepwheel	swissprot:KCNN1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNN1_HUMAN
pepwindow	swissprot:KCNN1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNN1_HUMAN
sigcleave	swissprot:KCNN1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNN1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AT2B2_HUMAN	Event=Alternative splicing; Named isoforms=8; Comment=There is a combination of two alternative spliced domains at N-terminal site A (Z, X, Y and W) and at C-terminal site C (A and B). So far the splice sites have only been studied independently. Experimental confirmation may be lacking for some isoforms.; Name=WB; Synonyms=AIIICI; IsoId=Q01814-1; Sequence=Displayed; Name=WA; Synonyms=AIIICII; IsoId=Q01814-2; Sequence=VSP_000386; Note=Contains a phosphoserine at position 1177. Contains a phosphoserine at position 1165. {ECO 0000244|PubMed 18669648, ECO 0000244|PubMed 24275569}; Name=YA; Synonyms=AIICII; IsoId=Q01814-3; Sequence=VSP_000385, VSP_000386; Note=Contains a phosphoserine at position 1163. Contains a phosphoserine at position 1151. {ECO 0000244|PubMed 18669648, ECO 0000244|PubMed 24275569}; Name=ZA; Synonyms=AICII; IsoId=Q01814-4; Sequence=VSP_000384, VSP_000386; Note=Contains a phosphoserine at position 1132. Contains a phosphoserine at position 1120. {ECO 0000244|PubMed 18669648, ECO 0000244|PubMed 24275569}; Name=YB; Synonyms=AIICI; IsoId=Q01814-5; Sequence=VSP_000385; Name=ZB; Synonyms=AICI; IsoId=Q01814-6; Sequence=VSP_000384; Name=XA; IsoId=Q01814-7; Sequence=VSP_040837, VSP_000386; Note=Contains a phosphoserine at position 1146. Contains a phosphoserine at position 1134. {ECO 0000244|PubMed 18669648, ECO 0000244|PubMed 24275569}; Name=XB; IsoId=Q01814-8; Sequence=VSP_040837; 
# AltName	AT2B2_HUMAN	Plasma membrane calcium ATPase isoform 2
# AltName	AT2B2_HUMAN	Plasma membrane calcium pump isoform 2
# BRENDA	3.6.3	2681
# BioGrid	106981	118
# CATALYTIC ACTIVITY	AT2B2_HUMAN	ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2). 
# CCDS	CCDS2601	-. [Q01814-6]
# CCDS	CCDS33701	-. [Q01814-1]
# CCDS	CCDS82733	-. [Q01814-4]
# ChiTaRS	ATP2B2	human
# Ensembl	ENST00000352432	ENSP00000324172; ENSG00000157087. [Q01814-1]
# Ensembl	ENST00000360273	ENSP00000353414; ENSG00000157087. [Q01814-1]
# Ensembl	ENST00000383800	ENSP00000373311; ENSG00000157087. [Q01814-6]
# Ensembl	ENST00000397077	ENSP00000380267; ENSG00000157087. [Q01814-6]
# Ensembl	ENST00000460129	ENSP00000424494; ENSG00000157087. [Q01814-4]
# ExpressionAtlas	Q01814	baseline and differential
# FUNCTION	AT2B2_HUMAN	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. 
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005783	endoplasmic reticulum; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0005929	cilium; IEA:Ensembl.
# GO_component	GO:0016324	apical plasma membrane; IEA:Ensembl.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0043025	neuronal cell body; IEA:Ensembl.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IBA:GO_Central.
# GO_component	GO:0045202	synapse; IEA:UniProtKB-SubCell.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005388	calcium-transporting ATPase activity; IDA:UniProtKB.
# GO_function	GO:0005509	calcium ion binding; IDA:UniProtKB.
# GO_function	GO:0005516	calmodulin binding; IDA:UniProtKB.
# GO_function	GO:0005524	ATP binding; IDA:UniProtKB.
# GO_function	GO:0008022	protein C-terminus binding; IPI:UniProtKB.
# GO_function	GO:0030165	PDZ domain binding; IDA:UniProtKB.
# GO_function	GO:0030899	calcium-dependent ATPase activity; IEA:Ensembl.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0006810	transport; NAS:UniProtKB.
# GO_process	GO:0006816	calcium ion transport; IMP:DFLAT.
# GO_process	GO:0006996	organelle organization; IEA:Ensembl.
# GO_process	GO:0007595	lactation; IEA:Ensembl.
# GO_process	GO:0007605	sensory perception of sound; IMP:UniProtKB.
# GO_process	GO:0007626	locomotory behavior; IEA:Ensembl.
# GO_process	GO:0008361	regulation of cell size; IEA:Ensembl.
# GO_process	GO:0021702	cerebellar Purkinje cell differentiation; IEA:Ensembl.
# GO_process	GO:0021707	cerebellar granule cell differentiation; IEA:Ensembl.
# GO_process	GO:0030182	neuron differentiation; IDA:UniProtKB.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0040011	locomotion; IEA:Ensembl.
# GO_process	GO:0042428	serotonin metabolic process; IEA:Ensembl.
# GO_process	GO:0045299	otolith mineralization; IEA:Ensembl.
# GO_process	GO:0046068	cGMP metabolic process; IEA:Ensembl.
# GO_process	GO:0048167	regulation of synaptic plasticity; IEA:Ensembl.
# GO_process	GO:0050808	synapse organization; IEA:Ensembl.
# GO_process	GO:0050885	neuromuscular process controlling balance; IEA:Ensembl.
# GO_process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound; IEA:Ensembl.
# GO_process	GO:0051480	regulation of cytosolic calcium ion concentration; IMP:DFLAT.
# GO_process	GO:0051928	positive regulation of calcium ion transport; IEA:Ensembl.
# GO_process	GO:0060088	auditory receptor cell stereocilium organization; IEA:Ensembl.
# GO_process	GO:0090102	cochlea development; IEA:Ensembl.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0005929	cilium
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0040011	locomotion
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.1110.10	-; 1.
# Gene3D	2.70.150.10	-; 2.
# Gene3D	3.40.1110.10	-; 1.
# Genevisible	Q01814	HS
# HGNC	HGNC:815	ATP2B2
# INTERACTION	AT2B2_HUMAN	P01258 CALCA; NbExp=2; IntAct=EBI-1174243, EBI-1018474; Q63622 Dlg2 (xeno); NbExp=2; IntAct=EBI-1174262, EBI-396947; Q8SQG9 SLC9A3R2 (xeno); NbExp=3; IntAct=EBI-1174262, EBI-1174758; 
# IntAct	Q01814	9
# InterPro	IPR001757	P_typ_ATPase
# InterPro	IPR004014	ATPase_P-typ_cation-transptr_N
# InterPro	IPR006068	ATPase_P-typ_cation-transptr_C
# InterPro	IPR006408	P-type_ATPase_IIB
# InterPro	IPR008250	ATPase_P-typ_transduc_dom_A
# InterPro	IPR018303	ATPase_P-typ_P_site
# InterPro	IPR022141	ATP_Ca_trans_C
# InterPro	IPR023214	HAD-like_dom
# InterPro	IPR023298	ATPase_P-typ_TM_dom
# InterPro	IPR023299	ATPase_P-typ_cyto_domN
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04970	Salivary secretion
# KEGG_Pathway	ko04972	Pancreatic secretion
# MIM	108733	gene
# Organism	AT2B2_HUMAN	Homo sapiens (Human)
# PIR	S22393	S22393
# PROSITE	PS00154	ATPASE_E1_E2
# Pfam	PF00122	E1-E2_ATPase; 2
# Pfam	PF00689	Cation_ATPase_C
# Pfam	PF00690	Cation_ATPase_N
# Pfam	PF08282	Hydrolase_3
# Pfam	PF12424	ATP_Ca_trans_C
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-418359	Reduction of cytosolic Ca++ levels
# Reactome	R-HSA-5578775	Ion homeostasis
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	AT2B2_HUMAN	Plasma membrane calcium-transporting ATPase 2
# RefSeq	NP_001001331	NM_001001331.2. [Q01814-1]
# RefSeq	NP_001317540	NM_001330611.1
# RefSeq	NP_001674	NM_001683.3. [Q01814-6]
# RefSeq	XP_005265236	XM_005265179.4. [Q01814-1]
# RefSeq	XP_006713238	XM_006713175.3. [Q01814-1]
# RefSeq	XP_011532054	XM_011533752.2. [Q01814-1]
# RefSeq	XP_016861970	XM_017006481.1. [Q01814-1]
# RefSeq	XP_016861971	XM_017006482.1. [Q01814-1]
# RefSeq	XP_016861972	XM_017006483.1. [Q01814-8]
# RefSeq	XP_016861973	XM_017006484.1. [Q01814-8]
# RefSeq	XP_016861975	XM_017006486.1. [Q01814-2]
# RefSeq	XP_016861978	XM_017006489.1. [Q01814-7]
# SIMILARITY	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. {ECO	0000305}.
# SMART	SM00831	Cation_ATPase_N
# SUBCELLULAR LOCATION	AT2B2_HUMAN	Cell junction, synapse {ECO 0000250|UniProtKB Q9R0K7}. Cell membrane {ECO 0000255}; Multi-pass membrane protein {ECO 0000255}. 
# SUBUNIT	Interacts with PDZD11. {ECO:0000269|PubMed	12763866}. 
# SUPFAM	SSF56784	SSF56784; 2
# SUPFAM	SSF81660	SSF81660
# TCDB	3.A.3.2.40	the p-type atpase (p-atpase) superfamily
# TIGRFAMs	TIGR01494	ATPase_P-type; 3
# TIGRFAMs	TIGR01517	ATPase-IIB_Ca
# TISSUE SPECIFICITY	AT2B2_HUMAN	Mainly expressed in brain cortex. Found in low levels in skeletal muscle, heart muscle, stomach, liver, kidney and lung. Isoforms containing segment B are found in brain cortex and at low levels in other tissues. Isoforms containing segments X and W are found at low levels in all tissues. Isoforms containing segment A and segment Z are found at low levels in skeletal muscle and heart muscle. 
# UCSC	uc003bvt	human. [Q01814-1]
# eggNOG	ENOG410XNNC	LUCA
# eggNOG	KOG0204	Eukaryota
BLAST	swissprot:AT2B2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AT2B2_HUMAN
BioCyc	ZFISH:HS08176-MONOMER	http://biocyc.org/getid?id=ZFISH:HS08176-MONOMER
COXPRESdb	491	http://coxpresdb.jp/data/gene/491.shtml
CleanEx	HS_ATP2B2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP2B2
DOI	10.1016/S0888-7543(05)80246-0	http://dx.doi.org/10.1016/S0888-7543(05)80246-0
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1111/j.1432-1033.1992.tb16784.x	http://dx.doi.org/10.1111/j.1432-1033.1992.tb16784.x
DOI	10.1111/j.1749-6632.2003.tb07230.x	http://dx.doi.org/10.1111/j.1749-6632.2003.tb07230.x
EC_number	EC:3.6.3.8	http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.8
EMBL	AC018839	http://www.ebi.ac.uk/ena/data/view/AC018839
EMBL	AC090841	http://www.ebi.ac.uk/ena/data/view/AC090841
EMBL	L00620	http://www.ebi.ac.uk/ena/data/view/L00620
EMBL	L20977	http://www.ebi.ac.uk/ena/data/view/L20977
EMBL	M97260	http://www.ebi.ac.uk/ena/data/view/M97260
EMBL	U15688	http://www.ebi.ac.uk/ena/data/view/U15688
EMBL	X63575	http://www.ebi.ac.uk/ena/data/view/X63575
ENZYME	3.6.3.8	http://enzyme.expasy.org/EC/3.6.3.8
Ensembl	ENST00000352432	http://www.ensembl.org/id/ENST00000352432
Ensembl	ENST00000360273	http://www.ensembl.org/id/ENST00000360273
Ensembl	ENST00000383800	http://www.ensembl.org/id/ENST00000383800
Ensembl	ENST00000397077	http://www.ensembl.org/id/ENST00000397077
Ensembl	ENST00000460129	http://www.ensembl.org/id/ENST00000460129
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005929	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005929
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_component	GO:0045202	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045202
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005388	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005388
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0005516	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005516
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0008022	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008022
GO_function	GO:0030165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030165
GO_function	GO:0030899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030899
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0006996	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006996
GO_process	GO:0007595	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007595
GO_process	GO:0007605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007605
GO_process	GO:0007626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007626
GO_process	GO:0008361	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008361
GO_process	GO:0021702	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021702
GO_process	GO:0021707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021707
GO_process	GO:0030182	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030182
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0040011	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011
GO_process	GO:0042428	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042428
GO_process	GO:0045299	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045299
GO_process	GO:0046068	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046068
GO_process	GO:0048167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048167
GO_process	GO:0050808	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050808
GO_process	GO:0050885	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050885
GO_process	GO:0050910	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050910
GO_process	GO:0051480	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051480
GO_process	GO:0051928	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051928
GO_process	GO:0060088	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060088
GO_process	GO:0090102	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090102
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0005929	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005929
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0040011	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.1110.10	http://www.cathdb.info/version/latest/superfamily/1.20.1110.10
Gene3D	2.70.150.10	http://www.cathdb.info/version/latest/superfamily/2.70.150.10
Gene3D	3.40.1110.10	http://www.cathdb.info/version/latest/superfamily/3.40.1110.10
GeneCards	ATP2B2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP2B2
GeneID	491	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=491
GeneTree	ENSGT00510000046331	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00510000046331
HGNC	HGNC:815	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:815
HOGENOM	HOG000265623	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265623&db=HOGENOM6
HOVERGEN	HBG061286	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG061286&db=HOVERGEN
HPA	CAB005606	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB005606
InParanoid	Q01814	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q01814
IntAct	Q01814	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q01814*
IntEnz	3.6.3.8	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.8
InterPro	IPR001757	http://www.ebi.ac.uk/interpro/entry/IPR001757
InterPro	IPR004014	http://www.ebi.ac.uk/interpro/entry/IPR004014
InterPro	IPR006068	http://www.ebi.ac.uk/interpro/entry/IPR006068
InterPro	IPR006408	http://www.ebi.ac.uk/interpro/entry/IPR006408
InterPro	IPR008250	http://www.ebi.ac.uk/interpro/entry/IPR008250
InterPro	IPR018303	http://www.ebi.ac.uk/interpro/entry/IPR018303
InterPro	IPR022141	http://www.ebi.ac.uk/interpro/entry/IPR022141
InterPro	IPR023214	http://www.ebi.ac.uk/interpro/entry/IPR023214
InterPro	IPR023298	http://www.ebi.ac.uk/interpro/entry/IPR023298
InterPro	IPR023299	http://www.ebi.ac.uk/interpro/entry/IPR023299
Jabion	491	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=491
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:491	http://www.genome.jp/dbget-bin/www_bget?hsa:491
KEGG_Orthology	KO:K05850	http://www.genome.jp/dbget-bin/www_bget?KO:K05850
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04970	http://www.genome.jp/kegg-bin/show_pathway?ko04970
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
MIM	108733	http://www.ncbi.nlm.nih.gov/omim/108733
MINT	MINT-470839	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-470839
OMA	GKMQDGS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GKMQDGS
OrthoDB	EOG091G057D	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G057D
PROSITE	PS00154	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00154
PSORT	swissprot:AT2B2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AT2B2_HUMAN
PSORT-B	swissprot:AT2B2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AT2B2_HUMAN
PSORT2	swissprot:AT2B2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AT2B2_HUMAN
Pfam	PF00122	http://pfam.xfam.org/family/PF00122
Pfam	PF00689	http://pfam.xfam.org/family/PF00689
Pfam	PF00690	http://pfam.xfam.org/family/PF00690
Pfam	PF08282	http://pfam.xfam.org/family/PF08282
Pfam	PF12424	http://pfam.xfam.org/family/PF12424
PharmGKB	PA25108	http://www.pharmgkb.org/do/serve?objId=PA25108&objCls=Gene
Phobius	swissprot:AT2B2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AT2B2_HUMAN
PhylomeDB	Q01814	http://phylomedb.org/?seqid=Q01814
ProteinModelPortal	Q01814	http://www.proteinmodelportal.org/query/uniprot/Q01814
PubMed	12763866	http://www.ncbi.nlm.nih.gov/pubmed/12763866
PubMed	1313367	http://www.ncbi.nlm.nih.gov/pubmed/1313367
PubMed	1427863	http://www.ncbi.nlm.nih.gov/pubmed/1427863
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	7989379	http://www.ncbi.nlm.nih.gov/pubmed/7989379
PubMed	8245032	http://www.ncbi.nlm.nih.gov/pubmed/8245032
PubMed	8428366	http://www.ncbi.nlm.nih.gov/pubmed/8428366
Reactome	R-HSA-418359	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418359
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_001001331	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001001331
RefSeq	NP_001317540	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001317540
RefSeq	NP_001674	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001674
RefSeq	XP_005265236	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005265236
RefSeq	XP_006713238	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006713238
RefSeq	XP_011532054	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011532054
RefSeq	XP_016861970	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016861970
RefSeq	XP_016861971	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016861971
RefSeq	XP_016861972	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016861972
RefSeq	XP_016861973	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016861973
RefSeq	XP_016861975	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016861975
RefSeq	XP_016861978	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016861978
SMART	SM00831	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00831
STRING	9606.ENSP00000324172	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000324172&targetmode=cogs
SUPFAM	SSF56784	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784
SUPFAM	SSF81660	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81660
TCDB	3.A.3.2.40	http://www.tcdb.org/search/result.php?tc=3.A.3.2.40
TIGRFAMs	TIGR01494	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01494
TIGRFAMs	TIGR01517	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01517
UCSC	uc003bvt	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003bvt&org=rat
UniGene	Hs.268942	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.268942
UniProtKB	AT2B2_HUMAN	http://www.uniprot.org/uniprot/AT2B2_HUMAN
UniProtKB-AC	Q01814	http://www.uniprot.org/uniprot/Q01814
charge	swissprot:AT2B2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AT2B2_HUMAN
eggNOG	ENOG410XNNC	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNNC
eggNOG	KOG0204	http://eggnogapi.embl.de/nog_data/html/tree/KOG0204
epestfind	swissprot:AT2B2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AT2B2_HUMAN
garnier	swissprot:AT2B2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AT2B2_HUMAN
helixturnhelix	swissprot:AT2B2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AT2B2_HUMAN
hmoment	swissprot:AT2B2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AT2B2_HUMAN
iep	swissprot:AT2B2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AT2B2_HUMAN
inforesidue	swissprot:AT2B2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AT2B2_HUMAN
neXtProt	NX_Q01814	http://www.nextprot.org/db/entry/NX_Q01814
octanol	swissprot:AT2B2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AT2B2_HUMAN
pepcoil	swissprot:AT2B2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AT2B2_HUMAN
pepdigest	swissprot:AT2B2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AT2B2_HUMAN
pepinfo	swissprot:AT2B2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AT2B2_HUMAN
pepnet	swissprot:AT2B2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AT2B2_HUMAN
pepstats	swissprot:AT2B2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AT2B2_HUMAN
pepwheel	swissprot:AT2B2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AT2B2_HUMAN
pepwindow	swissprot:AT2B2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AT2B2_HUMAN
sigcleave	swissprot:AT2B2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AT2B2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CA2D2_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=Alpha2delta-2a; IsoId=Q9NY47-1; Sequence=Displayed; Name=2; Synonyms=Alpha2delta-2b; IsoId=Q9NY47-2; Sequence=VSP_028059; Name=3; IsoId=Q9NY47-3; Sequence=VSP_028059, VSP_028060; Name=4; IsoId=Q9NY47-4; Sequence=VSP_028058, VSP_028059, VSP_028060; Name=5; Synonyms=Alpha2delta-2c; IsoId=Q9NY47-5; Sequence=VSP_028060; 
# AltName	CA2D2_HUMAN	Voltage-gated calcium channel subunit alpha-2/delta-2
# AltName	CA2D2_HUMAN	Voltage-gated calcium channel subunit alpha-2/delta-2
# BioGrid	114678	15
# CCDS	CCDS33763	-. [Q9NY47-2]
# CCDS	CCDS54588	-. [Q9NY47-1]
# CCDS	CCDS63647	-. [Q9NY47-3]
# CCDS	CCDS77748	-. [Q9NY47-4]
# ChiTaRS	CACNA2D2	human
# DOMAIN	CA2D2_HUMAN	The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha- 1 (CACNA1) subunit to the plasma membrane by an integrin-like switch. {ECO 0000250}. 
# DrugBank	DB00270	Isradipine
# DrugBank	DB00421	Spironolactone
# DrugBank	DB00996	Gabapentin
# DrugBank	DB01023	Felodipine
# DrugBank	DB01054	Nitrendipine
# DrugBank	DB01118	Amiodarone
# DrugBank	DB01244	Bepridil
# Ensembl	ENST00000266039	ENSP00000266039; ENSG00000007402. [Q9NY47-3]
# Ensembl	ENST00000360963	ENSP00000354228; ENSG00000007402. [Q9NY47-4]
# Ensembl	ENST00000424201	ENSP00000390329; ENSG00000007402. [Q9NY47-2]
# Ensembl	ENST00000479441	ENSP00000418081; ENSG00000007402. [Q9NY47-1]
# ExpressionAtlas	Q9NY47	baseline and differential
# FUNCTION	CA2D2_HUMAN	The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis. {ECO 0000269|PubMed 12555074, ECO 0000269|PubMed 15111129}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005891	voltage-gated calcium channel complex; IEA:Ensembl.
# GO_function	GO:0005245	voltage-gated calcium channel activity; TAS:Reactome.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0007528	neuromuscular junction development; IEA:Ensembl.
# GO_process	GO:0040014	regulation of multicellular organism growth; IEA:Ensembl.
# GO_process	GO:0046622	positive regulation of organ growth; IEA:Ensembl.
# GO_process	GO:0048747	muscle fiber development; IEA:Ensembl.
# GO_process	GO:0050796	regulation of insulin secretion; TAS:Reactome.
# GO_process	GO:0060024	rhythmic synaptic transmission; IEA:Ensembl.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# Gene3D	3.40.50.410	-; 1.
# Genevisible	Q9NY47	HS
# HGNC	HGNC:1400	CACNA2D2
# InterPro	IPR002035	VWF_A
# InterPro	IPR013608	VWA_N
# InterPro	IPR013680	VDCC_a2/dsu
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04010	MAPK signaling pathway
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05410	Hypertrophic cardiomyopathy (HCM)
# KEGG_Pathway	ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
# KEGG_Pathway	ko05414	Dilated cardiomyopathy
# MIM	607082	gene
# MISCELLANEOUS	CA2D2_HUMAN	Binds gabapentin, an antiepileptic drug. 
# Organism	CA2D2_HUMAN	Homo sapiens (Human)
# PROSITE	PS50234	VWFA
# PTM	CA2D2_HUMAN	May be proteolytically processed into subunits alpha-2-2 and delta-2 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role (By similarity). {ECO 0000250}. 
# Pfam	PF00092	VWA
# Pfam	PF08399	VWA_N
# Pfam	PF08473	VGCC_alpha2
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-112308	Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
# Reactome	R-HSA-400042	Adrenaline,noradrenaline inhibits insulin secretion
# Reactome	R-HSA-422356	Regulation of insulin secretion
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# Reactome	R-HSA-5576893	Phase 2 - plateau phase
# Reactome	R-HSA-5576894	Phase 1 - inactivation of fast Na+ channels
# RecName	CA2D2_HUMAN	Voltage-dependent calcium channel subunit alpha-2-2
# RecName	CA2D2_HUMAN	Voltage-dependent calcium channel subunit alpha-2-2
# RecName	CA2D2_HUMAN	Voltage-dependent calcium channel subunit alpha-2/delta-2
# RecName	CA2D2_HUMAN	Voltage-dependent calcium channel subunit delta-2
# RefSeq	NP_001005505	NM_001005505.2. [Q9NY47-3]
# RefSeq	NP_001167522	NM_001174051.2. [Q9NY47-1]
# RefSeq	NP_001278030	NM_001291101.1. [Q9NY47-4]
# RefSeq	NP_006021	NM_006030.3. [Q9NY47-2]
# SIMILARITY	Belongs to the calcium channel subunit alpha-2/delta family. {ECO	0000305}. 
# SIMILARITY	Contains 1 VWFA domain. {ECO:0000255|PROSITE- ProRule	PRU00219}.
# SIMILARITY	Contains 1 cache domain. {ECO	0000305}. 
# SMART	SM00327	VWA
# SUBCELLULAR LOCATION	CA2D2_HUMAN	Membrane {ECO 0000305}; Single-pass type I membrane protein {ECO 0000305}. Note=Colocalizes with CACNA1A in lipid raft fractions. {ECO 0000250}. 
# SUBUNIT	CA2D2_HUMAN	Dimer formed of alpha-2-2 and delta-2 chains; disulfide- linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1 1 1 1 ratio (By similarity). {ECO 0000250}. 
# SUPFAM	SSF53300	SSF53300
# TCDB	8.A.18.2	the ca(2+) channel auxiliary subunit Alpha2Delta types 1-4 (cca-Alpha2Delta) family
# TISSUE SPECIFICITY	CA2D2_HUMAN	Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta and brain. {ECO 0000269|PubMed 10766861, ECO 0000269|PubMed 11687876, ECO 0000269|PubMed 9880589}. 
# UCSC	uc003dap	human. [Q9NY47-1]
# eggNOG	ENOG410XPDX	LUCA
# eggNOG	KOG2353	Eukaryota
BLAST	swissprot:CA2D2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CA2D2_HUMAN
COXPRESdb	9254	http://coxpresdb.jp/data/gene/9254.shtml
CleanEx	HS_CACNA2D2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CACNA2D2
DOI	10.1007/s00232-001-0072-7	http://dx.doi.org/10.1007/s00232-001-0072-7
DOI	10.1016/j.abb.2004.03.010	http://dx.doi.org/10.1016/j.abb.2004.03.010
DOI	10.1023/B:JOBB.0000008028.41056.58	http://dx.doi.org/10.1023/B:JOBB.0000008028.41056.58
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1038/nbt.1532	http://dx.doi.org/10.1038/nbt.1532
DOI	10.1038/sj.onc.1206134	http://dx.doi.org/10.1038/sj.onc.1206134
DOI	10.1046/j.1460-9568.2000.01009.x	http://dx.doi.org/10.1046/j.1460-9568.2000.01009.x
DOI	10.1074/jbc.275.16.12237	http://dx.doi.org/10.1074/jbc.275.16.12237
DOI	10.1093/dnares/5.1.31	http://dx.doi.org/10.1093/dnares/5.1.31
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00270	http://www.drugbank.ca/drugs/DB00270
DrugBank	DB00421	http://www.drugbank.ca/drugs/DB00421
DrugBank	DB00996	http://www.drugbank.ca/drugs/DB00996
DrugBank	DB01023	http://www.drugbank.ca/drugs/DB01023
DrugBank	DB01054	http://www.drugbank.ca/drugs/DB01054
DrugBank	DB01118	http://www.drugbank.ca/drugs/DB01118
DrugBank	DB01244	http://www.drugbank.ca/drugs/DB01244
EMBL	AB011130	http://www.ebi.ac.uk/ena/data/view/AB011130
EMBL	AF040709	http://www.ebi.ac.uk/ena/data/view/AF040709
EMBL	AF042792	http://www.ebi.ac.uk/ena/data/view/AF042792
EMBL	AF042793	http://www.ebi.ac.uk/ena/data/view/AF042793
EMBL	AJ251367	http://www.ebi.ac.uk/ena/data/view/AJ251367
EMBL	AJ251368	http://www.ebi.ac.uk/ena/data/view/AJ251368
EMBL	AL450422	http://www.ebi.ac.uk/ena/data/view/AL450422
EMBL	BC152438	http://www.ebi.ac.uk/ena/data/view/BC152438
EMBL	CH471055	http://www.ebi.ac.uk/ena/data/view/CH471055
EMBL	Z75742	http://www.ebi.ac.uk/ena/data/view/Z75742
EMBL	Z75743	http://www.ebi.ac.uk/ena/data/view/Z75743
EMBL	Z84492	http://www.ebi.ac.uk/ena/data/view/Z84492
EMBL	Z84494	http://www.ebi.ac.uk/ena/data/view/Z84494
EMBL	Z84495	http://www.ebi.ac.uk/ena/data/view/Z84495
Ensembl	ENST00000266039	http://www.ensembl.org/id/ENST00000266039
Ensembl	ENST00000360963	http://www.ensembl.org/id/ENST00000360963
Ensembl	ENST00000424201	http://www.ensembl.org/id/ENST00000424201
Ensembl	ENST00000479441	http://www.ensembl.org/id/ENST00000479441
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005891
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0007528	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007528
GO_process	GO:0040014	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040014
GO_process	GO:0046622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046622
GO_process	GO:0048747	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048747
GO_process	GO:0050796	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050796
GO_process	GO:0060024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060024
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
Gene3D	3.40.50.410	http://www.cathdb.info/version/latest/superfamily/3.40.50.410
GeneCards	CACNA2D2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CACNA2D2
GeneID	9254	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9254
GeneTree	ENSGT00530000062904	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062904
HGNC	HGNC:1400	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1400
HOGENOM	HOG000004860	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000004860&db=HOGENOM6
HOVERGEN	HBG057779	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG057779&db=HOVERGEN
HPA	HPA034771	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA034771
InParanoid	Q9NY47	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NY47
IntAct	Q9NY47	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NY47*
InterPro	IPR002035	http://www.ebi.ac.uk/interpro/entry/IPR002035
InterPro	IPR013608	http://www.ebi.ac.uk/interpro/entry/IPR013608
InterPro	IPR013680	http://www.ebi.ac.uk/interpro/entry/IPR013680
Jabion	9254	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9254
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:9254	http://www.genome.jp/dbget-bin/www_bget?hsa:9254
KEGG_Orthology	KO:K04859	http://www.genome.jp/dbget-bin/www_bget?KO:K04859
KEGG_Pathway	ko04010	http://www.genome.jp/kegg-bin/show_pathway?ko04010
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05410	http://www.genome.jp/kegg-bin/show_pathway?ko05410
KEGG_Pathway	ko05412	http://www.genome.jp/kegg-bin/show_pathway?ko05412
KEGG_Pathway	ko05414	http://www.genome.jp/kegg-bin/show_pathway?ko05414
MIM	607082	http://www.ncbi.nlm.nih.gov/omim/607082
PROSITE	PS50234	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50234
PSORT	swissprot:CA2D2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CA2D2_HUMAN
PSORT-B	swissprot:CA2D2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CA2D2_HUMAN
PSORT2	swissprot:CA2D2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CA2D2_HUMAN
Pfam	PF00092	http://pfam.xfam.org/family/PF00092
Pfam	PF08399	http://pfam.xfam.org/family/PF08399
Pfam	PF08473	http://pfam.xfam.org/family/PF08473
PharmGKB	PA26012	http://www.pharmgkb.org/do/serve?objId=PA26012&objCls=Gene
Phobius	swissprot:CA2D2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CA2D2_HUMAN
ProteinModelPortal	Q9NY47	http://www.proteinmodelportal.org/query/uniprot/Q9NY47
PubMed	10762351	http://www.ncbi.nlm.nih.gov/pubmed/10762351
PubMed	10766861	http://www.ncbi.nlm.nih.gov/pubmed/10766861
PubMed	11687876	http://www.ncbi.nlm.nih.gov/pubmed/11687876
PubMed	12555074	http://www.ncbi.nlm.nih.gov/pubmed/12555074
PubMed	15000524	http://www.ncbi.nlm.nih.gov/pubmed/15000524
PubMed	15111129	http://www.ncbi.nlm.nih.gov/pubmed/15111129
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	19349973	http://www.ncbi.nlm.nih.gov/pubmed/19349973
PubMed	9628581	http://www.ncbi.nlm.nih.gov/pubmed/9628581
PubMed	9880589	http://www.ncbi.nlm.nih.gov/pubmed/9880589
Reactome	R-HSA-112308	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112308
Reactome	R-HSA-400042	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-400042
Reactome	R-HSA-422356	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-422356
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
Reactome	R-HSA-5576893	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576893
Reactome	R-HSA-5576894	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576894
RefSeq	NP_001005505	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001005505
RefSeq	NP_001167522	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001167522
RefSeq	NP_001278030	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001278030
RefSeq	NP_006021	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006021
SMART	SM00327	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00327
STRING	9606.ENSP00000418081	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000418081&targetmode=cogs
SUPFAM	SSF53300	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53300
TCDB	8.A.18.2	http://www.tcdb.org/search/result.php?tc=8.A.18.2
UCSC	uc003dap	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003dap&org=rat
UniGene	Hs.476273	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.476273
UniGene	Hs.674666	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.674666
UniProtKB	CA2D2_HUMAN	http://www.uniprot.org/uniprot/CA2D2_HUMAN
UniProtKB-AC	Q9NY47	http://www.uniprot.org/uniprot/Q9NY47
charge	swissprot:CA2D2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CA2D2_HUMAN
eggNOG	ENOG410XPDX	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPDX
eggNOG	KOG2353	http://eggnogapi.embl.de/nog_data/html/tree/KOG2353
epestfind	swissprot:CA2D2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CA2D2_HUMAN
garnier	swissprot:CA2D2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CA2D2_HUMAN
helixturnhelix	swissprot:CA2D2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CA2D2_HUMAN
hmoment	swissprot:CA2D2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CA2D2_HUMAN
iep	swissprot:CA2D2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CA2D2_HUMAN
inforesidue	swissprot:CA2D2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CA2D2_HUMAN
neXtProt	NX_Q9NY47	http://www.nextprot.org/db/entry/NX_Q9NY47
octanol	swissprot:CA2D2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CA2D2_HUMAN
pepcoil	swissprot:CA2D2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CA2D2_HUMAN
pepdigest	swissprot:CA2D2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CA2D2_HUMAN
pepinfo	swissprot:CA2D2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CA2D2_HUMAN
pepnet	swissprot:CA2D2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CA2D2_HUMAN
pepstats	swissprot:CA2D2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CA2D2_HUMAN
pepwheel	swissprot:CA2D2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CA2D2_HUMAN
pepwindow	swissprot:CA2D2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CA2D2_HUMAN
sigcleave	swissprot:CA2D2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CA2D2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GRIA2_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=Flop; IsoId=P42262-1; Sequence=Displayed; Name=Flip; IsoId=P42262-2; Sequence=VSP_053350; Name=3; Synonyms=Long; IsoId=P42262-3; Sequence=VSP_029309; Name=4; IsoId=P42262-4; Sequence=VSP_055920, VSP_053350; Note=No experimental confirmation available.; 
# AltName	GRIA2_HUMAN	AMPA-selective glutamate receptor 2
# AltName	GRIA2_HUMAN	GluR-B
# AltName	GRIA2_HUMAN	GluR-K2
# AltName	GRIA2_HUMAN	Glutamate receptor ionotropic, AMPA 2
# BioGrid	109148	30
# CCDS	CCDS3797	-. [P42262-2]
# CCDS	CCDS43274	-. [P42262-1]
# CCDS	CCDS43275	-. [P42262-4]
# ChiTaRS	GRIA2	human
# DOMAIN	GRIA2_HUMAN	The M4 transmembrane segment mediates tetramerization and is required for cell surface expression. 
# DrugBank	DB00237	Butabarbital
# DrugBank	DB00241	Butalbital
# DrugBank	DB00306	Talbutal
# DrugBank	DB00312	Pentobarbital
# DrugBank	DB00418	Secobarbital
# DrugBank	DB00599	Thiopental
# DrugBank	DB00794	Primidone
# DrugBank	DB00849	Methylphenobarbital
# DrugBank	DB00898	Ethanol
# DrugBank	DB01174	Phenobarbital
# DrugBank	DB01346	Quinidine barbiturate
# DrugBank	DB01351	Amobarbital
# DrugBank	DB01352	Aprobarbital
# DrugBank	DB01353	Butethal
# DrugBank	DB01354	Heptabarbital
# DrugBank	DB01355	Hexobarbital
# Ensembl	ENST00000264426	ENSP00000264426; ENSG00000120251. [P42262-1]
# Ensembl	ENST00000296526	ENSP00000296526; ENSG00000120251. [P42262-2]
# Ensembl	ENST00000393815	ENSP00000377403; ENSG00000120251. [P42262-4]
# Ensembl	ENST00000507898	ENSP00000426845; ENSG00000120251. [P42262-4]
# ExpressionAtlas	P42262	baseline and differential
# FUNCTION	GRIA2_HUMAN	Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. {ECO 0000269|PubMed 20614889}. 
# GO_component	GO:0005789	endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; ISS:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030666	endocytic vesicle membrane; TAS:Reactome.
# GO_component	GO:0032281	AMPA glutamate receptor complex; ISS:UniProtKB.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0004970	ionotropic glutamate receptor activity; IDA:UniProtKB.
# GO_function	GO:0004971	AMPA glutamate receptor activity; ISS:UniProtKB.
# GO_function	GO:0005231	excitatory extracellular ligand-gated ion channel activity; TAS:Reactome.
# GO_function	GO:0005234	extracellular-glutamate-gated ion channel activity; IEA:InterPro.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:ProtInc.
# GO_process	GO:0035235	ionotropic glutamate receptor signaling pathway; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# Genevisible	P42262	HS
# HGNC	HGNC:4572	GRIA2
# INTERACTION	GRIA2_HUMAN	P46459 NSF; NbExp=2; IntAct=EBI-3909876, EBI-712251; 
# IntAct	P42262	12
# InterPro	IPR001320	Iontro_rcpt
# InterPro	IPR001508	Iono_rcpt_met
# InterPro	IPR001828	ANF_lig-bd_rcpt
# InterPro	IPR019594	Glu/Gly-bd
# InterPro	IPR028082	Peripla_BP_I
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04713	Circadian entrainment
# KEGG_Pathway	ko04720	Long-term potentiation
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04724	Glutamatergic synapse
# KEGG_Pathway	ko04728	Dopaminergic synapse
# KEGG_Pathway	ko04730	Long-term depression
# KEGG_Pathway	ko05014	Amyotrophic lateral sclerosis (ALS)
# KEGG_Pathway	ko05030	Cocaine addiction
# KEGG_Pathway	ko05031	Amphetamine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# MIM	138247	gene
# MISCELLANEOUS	GRIA2_HUMAN	The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate. 
# Organism	GRIA2_HUMAN	Homo sapiens (Human)
# PDB	2WJW	X-ray; 1.80 A; A=25-412
# PDB	2WJX	X-ray; 4.10 A; A/B/C=25-412
# PDB	2XHD	X-ray; 1.80 A; A/B=413-527, A/B=653-796
# PDB	3R7X	X-ray; 2.10 A; A/B=413-527, A/B=653-796
# PDB	3RN8	X-ray; 1.70 A; A/B/C=413-527, A/B/C=653-812
# PDB	3RNN	X-ray; 1.75 A; A/B/C=413-527, A/B/C=653-812
# PDB	3UA8	X-ray; 1.90 A; A=413-527, A=653-796
# PDB	5H8S	X-ray; 1.70 A; A/B/C=413-527, A/B/C=653-796
# PIR	I58181	I58181
# PRINTS	PR00177	NMDARECEPTOR
# PTM	GRIA2_HUMAN	Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity). {ECO 0000250}. 
# Pfam	PF00060	Lig_chan
# Pfam	PF01094	ANF_receptor
# Pfam	PF10613	Lig_chan-Glu_bd
# Proteomes	UP000005640	Chromosome 4
# RNA EDITING	Modified_positions=607 {ECO:0000269|PubMed	7523595}; Note=Partially edited. Fully edited in the brain. Heteromerically expressed edited GLUR2 (R) receptor complexes are impermeable to calcium, whereas the unedited (Q) forms are highly permeable to divalent ions.; 
# Reactome	R-HSA-399710	Activation of AMPA receptors
# Reactome	R-HSA-416993	Trafficking of GluR2-containing AMPA receptors
# Reactome	R-HSA-438066	Unblocking of NMDA receptor, glutamate binding and activation
# RecName	GRIA2_HUMAN	Glutamate receptor 2
# RefSeq	NP_000817	NM_000826.3
# RefSeq	NP_001077088	NM_001083619.1
# RefSeq	NP_001077089	NM_001083620.1
# RefSeq	XP_016863605	XM_017008116.1. [P42262-4]
# RefSeq	XP_016863606	XM_017008117.1. [P42262-4]
# SIMILARITY	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily. {ECO	0000305}.
# SMART	SM00079	PBPe
# SMART	SM00918	Lig_chan-Glu_bd
# SUBCELLULAR LOCATION	GRIA2_HUMAN	Cell membrane {ECO 0000269|PubMed 23739980}; Multi-pass membrane protein {ECO 0000269|PubMed 23739980}. Endoplasmic reticulum membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO 0000269|PubMed 23739980}; Multi-pass membrane protein {ECO 0000269|PubMed 23739980}. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. {ECO 0000250}. 
# SUBUNIT	Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. May interact with MPP4. Forms a ternary complex with GRIP1 and CSPG4. Interacts with ATAD1 in an ATP-dependent manner. ATAD1- catalyzed ATP hydrolysis disrupts binding to ATAD1 and to GRIP1 and leads to AMPAR complex disassembly (By similarity). Interacts with PICK1 (via PDZ domain). Interacts with PRKCABP and GRIP2 (By similarity). Interacts with GRIA1 and SYNDIG1 (By similarity). Interacts with LRFN1. Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes (By similarity). Found in a complex with GRIA1, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CACNG5 (By similarity). Interacts with OLFM2 (By similarity). {ECO:0000250|UniProtKB	P23819}. 
# SUPFAM	SSF53822	SSF53822
# TCDB	1.A.10.1.13	the glutamate-gated ion channel (gic) family of neurotransmitter receptors
# UCSC	uc003ipk	human. [P42262-1]
# eggNOG	ENOG410XPSH	LUCA
# eggNOG	KOG1054	Eukaryota
BLAST	swissprot:GRIA2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GRIA2_HUMAN
BioCyc	ZFISH:ENSG00000120251-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000120251-MONOMER
COXPRESdb	2891	http://coxpresdb.jp/data/gene/2891.shtml
CleanEx	HS_GRIA2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GRIA2
DIP	DIP-42852N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-42852N
DOI	10.1016/S0896-6273(03)00722-0	http://dx.doi.org/10.1016/S0896-6273(03)00722-0
DOI	10.1016/j.bmcl.2011.04.017	http://dx.doi.org/10.1016/j.bmcl.2011.04.017
DOI	10.1016/j.jmb.2009.07.082	http://dx.doi.org/10.1016/j.jmb.2009.07.082
DOI	10.1021/jm1005429	http://dx.doi.org/10.1021/jm1005429
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1074/jbc.M404499200	http://dx.doi.org/10.1074/jbc.M404499200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1523/JNEUROSCI.2626-12.2013	http://dx.doi.org/10.1523/JNEUROSCI.2626-12.2013
DrugBank	DB00237	http://www.drugbank.ca/drugs/DB00237
DrugBank	DB00241	http://www.drugbank.ca/drugs/DB00241
DrugBank	DB00306	http://www.drugbank.ca/drugs/DB00306
DrugBank	DB00312	http://www.drugbank.ca/drugs/DB00312
DrugBank	DB00418	http://www.drugbank.ca/drugs/DB00418
DrugBank	DB00599	http://www.drugbank.ca/drugs/DB00599
DrugBank	DB00794	http://www.drugbank.ca/drugs/DB00794
DrugBank	DB00849	http://www.drugbank.ca/drugs/DB00849
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01174	http://www.drugbank.ca/drugs/DB01174
DrugBank	DB01346	http://www.drugbank.ca/drugs/DB01346
DrugBank	DB01351	http://www.drugbank.ca/drugs/DB01351
DrugBank	DB01352	http://www.drugbank.ca/drugs/DB01352
DrugBank	DB01353	http://www.drugbank.ca/drugs/DB01353
DrugBank	DB01354	http://www.drugbank.ca/drugs/DB01354
DrugBank	DB01355	http://www.drugbank.ca/drugs/DB01355
EMBL	AC079233	http://www.ebi.ac.uk/ena/data/view/AC079233
EMBL	AC112240	http://www.ebi.ac.uk/ena/data/view/AC112240
EMBL	BC010574	http://www.ebi.ac.uk/ena/data/view/BC010574
EMBL	BC028736	http://www.ebi.ac.uk/ena/data/view/BC028736
EMBL	L20814	http://www.ebi.ac.uk/ena/data/view/L20814
Ensembl	ENST00000264426	http://www.ensembl.org/id/ENST00000264426
Ensembl	ENST00000296526	http://www.ensembl.org/id/ENST00000296526
Ensembl	ENST00000393815	http://www.ensembl.org/id/ENST00000393815
Ensembl	ENST00000507898	http://www.ensembl.org/id/ENST00000507898
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030666
GO_component	GO:0032281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032281
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0004970	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004970
GO_function	GO:0004971	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004971
GO_function	GO:0005231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005231
GO_function	GO:0005234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005234
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0035235	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035235
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GeneCards	GRIA2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GRIA2
GeneID	2891	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2891
GeneTree	ENSGT00760000118920	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118920
HGNC	HGNC:4572	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4572
HOGENOM	HOG000234372	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234372&db=HOGENOM6
HOVERGEN	HBG051839	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051839&db=HOVERGEN
HPA	CAB006830	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB006830
HPA	CAB007812	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB007812
HPA	CAB012981	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB012981
HPA	HPA008441	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA008441
InParanoid	P42262	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P42262
IntAct	P42262	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P42262*
InterPro	IPR001320	http://www.ebi.ac.uk/interpro/entry/IPR001320
InterPro	IPR001508	http://www.ebi.ac.uk/interpro/entry/IPR001508
InterPro	IPR001828	http://www.ebi.ac.uk/interpro/entry/IPR001828
InterPro	IPR019594	http://www.ebi.ac.uk/interpro/entry/IPR019594
InterPro	IPR028082	http://www.ebi.ac.uk/interpro/entry/IPR028082
Jabion	2891	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2891
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:2891	http://www.genome.jp/dbget-bin/www_bget?hsa:2891
KEGG_Orthology	KO:K05198	http://www.genome.jp/dbget-bin/www_bget?KO:K05198
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04713	http://www.genome.jp/kegg-bin/show_pathway?ko04713
KEGG_Pathway	ko04720	http://www.genome.jp/kegg-bin/show_pathway?ko04720
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
KEGG_Pathway	ko04728	http://www.genome.jp/kegg-bin/show_pathway?ko04728
KEGG_Pathway	ko04730	http://www.genome.jp/kegg-bin/show_pathway?ko04730
KEGG_Pathway	ko05014	http://www.genome.jp/kegg-bin/show_pathway?ko05014
KEGG_Pathway	ko05030	http://www.genome.jp/kegg-bin/show_pathway?ko05030
KEGG_Pathway	ko05031	http://www.genome.jp/kegg-bin/show_pathway?ko05031
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
MIM	138247	http://www.ncbi.nlm.nih.gov/omim/138247
MINT	MINT-2791741	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-2791741
OMA	IQRWSTL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IQRWSTL
OrthoDB	EOG091G11CB	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G11CB
PDB	2WJW	http://www.ebi.ac.uk/pdbe-srv/view/entry/2WJW
PDB	2WJX	http://www.ebi.ac.uk/pdbe-srv/view/entry/2WJX
PDB	2XHD	http://www.ebi.ac.uk/pdbe-srv/view/entry/2XHD
PDB	3R7X	http://www.ebi.ac.uk/pdbe-srv/view/entry/3R7X
PDB	3RN8	http://www.ebi.ac.uk/pdbe-srv/view/entry/3RN8
PDB	3RNN	http://www.ebi.ac.uk/pdbe-srv/view/entry/3RNN
PDB	3UA8	http://www.ebi.ac.uk/pdbe-srv/view/entry/3UA8
PDB	5H8S	http://www.ebi.ac.uk/pdbe-srv/view/entry/5H8S
PDBsum	2WJW	http://www.ebi.ac.uk/pdbsum/2WJW
PDBsum	2WJX	http://www.ebi.ac.uk/pdbsum/2WJX
PDBsum	2XHD	http://www.ebi.ac.uk/pdbsum/2XHD
PDBsum	3R7X	http://www.ebi.ac.uk/pdbsum/3R7X
PDBsum	3RN8	http://www.ebi.ac.uk/pdbsum/3RN8
PDBsum	3RNN	http://www.ebi.ac.uk/pdbsum/3RNN
PDBsum	3UA8	http://www.ebi.ac.uk/pdbsum/3UA8
PDBsum	5H8S	http://www.ebi.ac.uk/pdbsum/5H8S
PRINTS	PR00177	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00177
PSORT	swissprot:GRIA2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GRIA2_HUMAN
PSORT-B	swissprot:GRIA2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GRIA2_HUMAN
PSORT2	swissprot:GRIA2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GRIA2_HUMAN
Pfam	PF00060	http://pfam.xfam.org/family/PF00060
Pfam	PF01094	http://pfam.xfam.org/family/PF01094
Pfam	PF10613	http://pfam.xfam.org/family/PF10613
PharmGKB	PA28967	http://www.pharmgkb.org/do/serve?objId=PA28967&objCls=Gene
Phobius	swissprot:GRIA2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GRIA2_HUMAN
PhylomeDB	P42262	http://phylomedb.org/?seqid=P42262
ProteinModelPortal	P42262	http://www.proteinmodelportal.org/query/uniprot/P42262
PubMed	14687553	http://www.ncbi.nlm.nih.gov/pubmed/14687553
PubMed	15247289	http://www.ncbi.nlm.nih.gov/pubmed/15247289
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	19651138	http://www.ncbi.nlm.nih.gov/pubmed/19651138
PubMed	20614889	http://www.ncbi.nlm.nih.gov/pubmed/20614889
PubMed	21531559	http://www.ncbi.nlm.nih.gov/pubmed/21531559
PubMed	23739980	http://www.ncbi.nlm.nih.gov/pubmed/23739980
PubMed	7523595	http://www.ncbi.nlm.nih.gov/pubmed/7523595
PubMed	8003671	http://www.ncbi.nlm.nih.gov/pubmed/8003671
Reactome	R-HSA-399710	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-399710
Reactome	R-HSA-416993	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-416993
Reactome	R-HSA-438066	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-438066
RefSeq	NP_000817	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000817
RefSeq	NP_001077088	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001077088
RefSeq	NP_001077089	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001077089
RefSeq	XP_016863605	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016863605
RefSeq	XP_016863606	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016863606
SMART	SM00079	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00079
SMART	SM00918	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00918
SMR	P42262	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P42262
STRING	9606.ENSP00000264426	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000264426&targetmode=cogs
SUPFAM	SSF53822	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822
TCDB	1.A.10.1.13	http://www.tcdb.org/search/result.php?tc=1.A.10.1.13
UCSC	uc003ipk	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ipk&org=rat
UniGene	Hs.32763	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.32763
UniProtKB	GRIA2_HUMAN	http://www.uniprot.org/uniprot/GRIA2_HUMAN
UniProtKB-AC	P42262	http://www.uniprot.org/uniprot/P42262
charge	swissprot:GRIA2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GRIA2_HUMAN
eggNOG	ENOG410XPSH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPSH
eggNOG	KOG1054	http://eggnogapi.embl.de/nog_data/html/tree/KOG1054
epestfind	swissprot:GRIA2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GRIA2_HUMAN
garnier	swissprot:GRIA2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GRIA2_HUMAN
helixturnhelix	swissprot:GRIA2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GRIA2_HUMAN
hmoment	swissprot:GRIA2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GRIA2_HUMAN
iep	swissprot:GRIA2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GRIA2_HUMAN
inforesidue	swissprot:GRIA2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GRIA2_HUMAN
neXtProt	NX_P42262	http://www.nextprot.org/db/entry/NX_P42262
octanol	swissprot:GRIA2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GRIA2_HUMAN
pepcoil	swissprot:GRIA2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GRIA2_HUMAN
pepdigest	swissprot:GRIA2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GRIA2_HUMAN
pepinfo	swissprot:GRIA2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GRIA2_HUMAN
pepnet	swissprot:GRIA2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GRIA2_HUMAN
pepstats	swissprot:GRIA2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GRIA2_HUMAN
pepwheel	swissprot:GRIA2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GRIA2_HUMAN
pepwindow	swissprot:GRIA2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GRIA2_HUMAN
sigcleave	swissprot:GRIA2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GRIA2_HUMAN
## Database	ID	URL or Descriptions
# AltName	CY24B_HUMAN	CGD91-phox
# AltName	CY24B_HUMAN	Cytochrome b(558) subunit beta
# AltName	CY24B_HUMAN	Heme-binding membrane glycoprotein gp91phox
# AltName	CY24B_HUMAN	NADPH oxidase 2
# AltName	CY24B_HUMAN	Neutrophil cytochrome b 91 kDa polypeptide
# AltName	CY24B_HUMAN	Superoxide-generating NADPH oxidase heavy chain subunit
# AltName	CY24B_HUMAN	gp91-1
# AltName	CY24B_HUMAN	gp91-phox
# AltName	CY24B_HUMAN	p22 phagocyte B-cytochrome
# BioGrid	107916	3
# COFACTOR	Name=FAD; Xref=ChEBI:CHEBI	57692; Evidence={ECO:0000305}; 
# ChiTaRS	CYBB	human
# DISEASE	CY24B_HUMAN	Granulomatous disease, chronic, X-linked (CGD) [MIM 306400]  A disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections. {ECO 0000269|PubMed 10089913, ECO 0000269|PubMed 10914676, ECO 0000269|PubMed 11462241, ECO 0000269|PubMed 11997083, ECO 0000269|PubMed 12139950, ECO 0000269|PubMed 1710153, ECO 0000269|PubMed 18773283, ECO 0000269|PubMed 22125116, ECO 0000269|PubMed 23910690, ECO 0000269|PubMed 2556453, ECO 0000269|PubMed 7927345, ECO 0000269|PubMed 8101486, ECO 0000269|PubMed 8182143, ECO 0000269|PubMed 8916969, ECO 0000269|PubMed 9111587, ECO 0000269|PubMed 9585602, ECO 0000269|PubMed 9667376, ECO 0000269|PubMed 9794433, ECO 0000269|PubMed 9856476, ECO 0000269|PubMed 9888386}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CY24B_HUMAN	Immunodeficiency 34 (IMD34) [MIM 300645]  A form of Mendelian susceptibility to mycobacterial disease, a rare condition characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine, environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. {ECO 0000269|PubMed 21278736}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# DrugBank	DB00514	Dextromethorphan
# Ensembl	ENST00000378588	ENSP00000367851; ENSG00000165168
# ExpressionAtlas	P04839	baseline and differential
# FUNCTION	CY24B_HUMAN	Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. 
# GO_component	GO:0005635	nuclear envelope; IEA:Ensembl.
# GO_component	GO:0005739	mitochondrion; IEA:Ensembl.
# GO_component	GO:0005789	endoplasmic reticulum membrane; TAS:Reactome.
# GO_component	GO:0005791	rough endoplasmic reticulum; IEA:Ensembl.
# GO_component	GO:0005794	Golgi apparatus; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0030425	dendrite; IEA:Ensembl.
# GO_component	GO:0030670	phagocytic vesicle membrane; TAS:Reactome.
# GO_component	GO:0043020	NADPH oxidase complex; IDA:BHF-UCL.
# GO_component	GO:0043025	neuronal cell body; IEA:Ensembl.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IEA:Ensembl.
# GO_function	GO:0005244	voltage-gated ion channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0016175	superoxide-generating NADPH oxidase activity; TAS:BHF-UCL.
# GO_function	GO:0020037	heme binding; IMP:BHF-UCL.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_function	GO:0046982	protein heterodimerization activity; IPI:BHF-UCL.
# GO_function	GO:0050660	flavin adenine dinucleotide binding; IMP:BHF-UCL.
# GO_process	GO:0000302	response to reactive oxygen species; TAS:Reactome.
# GO_process	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome.
# GO_process	GO:0006801	superoxide metabolic process; IDA:BHF-UCL.
# GO_process	GO:0006954	inflammatory response; ISS:UniProtKB.
# GO_process	GO:0007584	response to nutrient; IEA:Ensembl.
# GO_process	GO:0042493	response to drug; IEA:Ensembl.
# GO_process	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process; IEA:Ensembl.
# GO_process	GO:0042554	superoxide anion generation; IDA:BHF-UCL.
# GO_process	GO:0045087	innate immune response; IMP:BHF-UCL.
# GO_process	GO:0045454	cell redox homeostasis; TAS:Reactome.
# GO_process	GO:0045730	respiratory burst; IMP:BHF-UCL.
# GO_process	GO:0045766	positive regulation of angiogenesis; IEA:Ensembl.
# GO_process	GO:0048010	vascular endothelial growth factor receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0050665	hydrogen peroxide biosynthetic process; IEA:Ensembl.
# GO_process	GO:0055114	oxidation-reduction process; IDA:BHF-UCL.
# GO_process	GO:0071276	cellular response to cadmium ion; IEA:Ensembl.
# GO_process	GO:0071361	cellular response to ethanol; IEA:Ensembl.
# GO_process	GO:0097411	hypoxia-inducible factor-1alpha signaling pathway; IEA:Ensembl.
# GO_process	GO:1904044	response to aldosterone; IEA:Ensembl.
# GO_process	GO:1904845	cellular response to L-glutamine; IEA:Ensembl.
# GO_process	GO:1990776	response to angiotensin; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005635	nuclear envelope
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0042592	homeostatic process
# Genevisible	P04839	HS
# HGNC	HGNC:2578	CYBB
# InterPro	IPR000778	Cyt_b245_heavy_chain
# InterPro	IPR013112	FAD-bd_8
# InterPro	IPR013121	Fe_red_NAD-bd_6
# InterPro	IPR013130	Fe3_Rdtase_TM_dom
# InterPro	IPR017927	Fd_Rdtase_FAD-bd
# InterPro	IPR017938	Riboflavin_synthase-like_b-brl
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Disease	H00098	[Primary immunodeficiency] p67phox deficiency (p67phox CGD)
# KEGG_Disease	H01167	[Infectious disease] Gluconobacter infection
# KEGG_Pathway	ko04066	HIF-1 signaling pathway
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko04380	Osteoclast differentiation
# KEGG_Pathway	ko04670	Leukocyte transendothelial migration
# MIM	300481	gene
# MIM	300645	phenotype
# MIM	306400	phenotype
# Organism	CY24B_HUMAN	Homo sapiens (Human)
# Orphanet	319623	X-linked mendelian susceptibility to mycobacterial diseases due to CYBB deficiency
# Orphanet	379	Chronic granulomatous disease
# PDB	3A1F	X-ray; 2.00 A; A=385-570
# PIR	S70773	S70773
# PRINTS	PR00466	GP91PHOX
# PROSITE	PS51384	FAD_FR
# PTM	CY24B_HUMAN	Glycosylated. {ECO 0000269|PubMed 19159218}. 
# PTM	CY24B_HUMAN	Phosphorylated on Ser and Thr residues. {ECO 0000269|PubMed 19028840}. 
# PeroxiBase	5962	HsNOx02
# Pfam	PF01794	Ferric_reduct
# Pfam	PF08022	FAD_binding_8
# Pfam	PF08030	NAD_binding_6
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-1222556	ROS, RNS production in response to bacteria
# Reactome	R-HSA-1236973	Cross-presentation of particulate exogenous antigens (phagosomes)
# Reactome	R-HSA-3299685	Detoxification of Reactive Oxygen Species
# Reactome	R-HSA-4420097	VEGFA-VEGFR2 Pathway
# Reactome	R-HSA-5668599	RHO GTPases Activate NADPH Oxidases
# Reactome	R-HSA-6798695	Neutrophil degranulation
# RecName	CY24B_HUMAN	Cytochrome b-245 heavy chain
# RefSeq	NP_000388	NM_000397.3
# SEQUENCE CAUTION	Sequence=CAA27635.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA29327.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305}; 
# SIMILARITY	Contains 1 FAD-binding FR-type domain. {ECO:0000255|PROSITE-ProRule	PRU00716}. 
# SIMILARITY	Contains 1 ferric oxidoreductase domain. {ECO	0000305}. 
# SUBCELLULAR LOCATION	CY24B_HUMAN	Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	CY24B_HUMAN	Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1. Interacts with calprotectin (S100A8/9). Interacts with NRROS; the interaction is direct and impairs formation of a stable NADPH oxidase complex. {ECO 0000269|PubMed 19028840, ECO 0000269|PubMed 3600769, ECO 0000269|PubMed 9224653}. 
# SUPFAM	SSF63380	SSF63380
# TCDB	5.B.1.1	the phagocyte (gp91(phox)) nadph oxidase family
# TISSUE SPECIFICITY	Detected in neutrophils (at protein level). {ECO:0000269|PubMed	19028840}. 
# UCSC	uc004ddr	human
# WEB RESOURCE	CY24B_HUMAN	Name=CYBBbase; Note=CYBB deficiency database; URL="http //structure.bmc.lu.se/idbase/CYBBbase/"; 
# WEB RESOURCE	CY24B_HUMAN	Name=Mendelian genes cytochrome b-245, beta polypeptide (CYBB); Note=Leiden Open Variation Database (LOVD); URL="http //www.lovd.nl/CYBB";
# eggNOG	ENOG410XNZY	LUCA
# eggNOG	KOG0039	Eukaryota
BLAST	swissprot:CY24B_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CY24B_HUMAN
BioCyc	ZFISH:HS09192-MONOMER	http://biocyc.org/getid?id=ZFISH:HS09192-MONOMER
COXPRESdb	1536	http://coxpresdb.jp/data/gene/1536.shtml
CleanEx	HS_CYBB	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CYBB
DIP	DIP-42005N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-42005N
DOI	10.1002/(SICI)1098-1004(1999)13:1<29::AID-HUMU3>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1999)13:1<29::AID-HUMU3>3.0.CO
DOI	10.1002/humu.1166	http://dx.doi.org/10.1002/humu.1166
DOI	10.1002/humu.22003	http://dx.doi.org/10.1002/humu.22003
DOI	10.1006/clim.2002.5230	http://dx.doi.org/10.1006/clim.2002.5230
DOI	10.1006/geno.1998.5510	http://dx.doi.org/10.1006/geno.1998.5510
DOI	10.1007/BF00201609	http://dx.doi.org/10.1007/BF00201609
DOI	10.1007/BF01955051	http://dx.doi.org/10.1007/BF01955051
DOI	10.1007/s00439-004-1173-z	http://dx.doi.org/10.1007/s00439-004-1173-z
DOI	10.1007/s004390000288	http://dx.doi.org/10.1007/s004390000288
DOI	10.1007/s004390050836	http://dx.doi.org/10.1007/s004390050836
DOI	10.1007/s10875-008-9243-y	http://dx.doi.org/10.1007/s10875-008-9243-y
DOI	10.1016/S0301-472X(98)00024-1	http://dx.doi.org/10.1016/S0301-472X(98)00024-1
DOI	10.1016/S0925-4439(01)00110-7	http://dx.doi.org/10.1016/S0925-4439(01)00110-7
DOI	10.1016/j.jaci.2013.05.039	http://dx.doi.org/10.1016/j.jaci.2013.05.039
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/322032a0	http://dx.doi.org/10.1038/322032a0
DOI	10.1038/327717a0	http://dx.doi.org/10.1038/327717a0
DOI	10.1038/327720a0	http://dx.doi.org/10.1038/327720a0
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/ni.1992	http://dx.doi.org/10.1038/ni.1992
DOI	10.1042/bj3250249	http://dx.doi.org/10.1042/bj3250249
DOI	10.1085/jgp.114.6.771	http://dx.doi.org/10.1085/jgp.114.6.771
DOI	10.1086/301874	http://dx.doi.org/10.1086/301874
DOI	10.1096/fj.08-114553	http://dx.doi.org/10.1096/fj.08-114553
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1172/JCI114393	http://dx.doi.org/10.1172/JCI114393
DOI	10.1172/JCI117207	http://dx.doi.org/10.1172/JCI117207
DOI	10.1203/00006450-199807000-00014	http://dx.doi.org/10.1203/00006450-199807000-00014
DrugBank	DB00514	http://www.drugbank.ca/drugs/DB00514
EC_number	EC:1.-.-.-	http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.-
EMBL	AB013904	http://www.ebi.ac.uk/ena/data/view/AB013904
EMBL	AF469757	http://www.ebi.ac.uk/ena/data/view/AF469757
EMBL	AF469758	http://www.ebi.ac.uk/ena/data/view/AF469758
EMBL	AF469759	http://www.ebi.ac.uk/ena/data/view/AF469759
EMBL	AF469760	http://www.ebi.ac.uk/ena/data/view/AF469760
EMBL	AF469761	http://www.ebi.ac.uk/ena/data/view/AF469761
EMBL	AF469762	http://www.ebi.ac.uk/ena/data/view/AF469762
EMBL	AF469763	http://www.ebi.ac.uk/ena/data/view/AF469763
EMBL	AF469764	http://www.ebi.ac.uk/ena/data/view/AF469764
EMBL	AF469765	http://www.ebi.ac.uk/ena/data/view/AF469765
EMBL	AF469766	http://www.ebi.ac.uk/ena/data/view/AF469766
EMBL	AF469767	http://www.ebi.ac.uk/ena/data/view/AF469767
EMBL	AF469768	http://www.ebi.ac.uk/ena/data/view/AF469768
EMBL	AF469769	http://www.ebi.ac.uk/ena/data/view/AF469769
EMBL	AK289753	http://www.ebi.ac.uk/ena/data/view/AK289753
EMBL	BC032720	http://www.ebi.ac.uk/ena/data/view/BC032720
EMBL	CH471141	http://www.ebi.ac.uk/ena/data/view/CH471141
EMBL	DQ314869	http://www.ebi.ac.uk/ena/data/view/DQ314869
EMBL	X04011	http://www.ebi.ac.uk/ena/data/view/X04011
EMBL	X05895	http://www.ebi.ac.uk/ena/data/view/X05895
ENZYME	1.-.-.-	http://enzyme.expasy.org/EC/1.-.-.-
Ensembl	ENST00000378588	http://www.ensembl.org/id/ENST00000378588
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005791	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005791
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0030670	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030670
GO_component	GO:0043020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043020
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_function	GO:0005244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005244
GO_function	GO:0016175	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016175
GO_function	GO:0020037	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_function	GO:0046982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046982
GO_function	GO:0050660	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660
GO_process	GO:0000302	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000302
GO_process	GO:0002479	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002479
GO_process	GO:0006801	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006801
GO_process	GO:0006954	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006954
GO_process	GO:0007584	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007584
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0042535	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042535
GO_process	GO:0042554	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042554
GO_process	GO:0045087	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045087
GO_process	GO:0045454	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045454
GO_process	GO:0045730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045730
GO_process	GO:0045766	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045766
GO_process	GO:0048010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048010
GO_process	GO:0050665	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050665
GO_process	GO:0055114	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114
GO_process	GO:0071276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071276
GO_process	GO:0071361	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071361
GO_process	GO:0097411	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097411
GO_process	GO:1904044	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1904044
GO_process	GO:1904845	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1904845
GO_process	GO:1990776	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990776
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GeneCards	CYBB	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CYBB
GeneID	1536	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1536
GeneTree	ENSGT00550000074350	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074350
HGNC	HGNC:2578	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2578
HOGENOM	HOG000216669	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000216669&db=HOGENOM6
HOVERGEN	HBG003760	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003760&db=HOVERGEN
HPA	HPA051227	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA051227
InParanoid	P04839	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P04839
IntAct	P04839	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P04839*
IntEnz	1	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1
InterPro	IPR000778	http://www.ebi.ac.uk/interpro/entry/IPR000778
InterPro	IPR013112	http://www.ebi.ac.uk/interpro/entry/IPR013112
InterPro	IPR013121	http://www.ebi.ac.uk/interpro/entry/IPR013121
InterPro	IPR013130	http://www.ebi.ac.uk/interpro/entry/IPR013130
InterPro	IPR017927	http://www.ebi.ac.uk/interpro/entry/IPR017927
InterPro	IPR017938	http://www.ebi.ac.uk/interpro/entry/IPR017938
Jabion	1536	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1536
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Disease	H00098	http://www.genome.jp/dbget-bin/www_bget?H00098
KEGG_Disease	H01167	http://www.genome.jp/dbget-bin/www_bget?H01167
KEGG_Gene	hsa:1536	http://www.genome.jp/dbget-bin/www_bget?hsa:1536
KEGG_Orthology	KO:K08008	http://www.genome.jp/dbget-bin/www_bget?KO:K08008
KEGG_Pathway	ko04066	http://www.genome.jp/kegg-bin/show_pathway?ko04066
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko04380	http://www.genome.jp/kegg-bin/show_pathway?ko04380
KEGG_Pathway	ko04670	http://www.genome.jp/kegg-bin/show_pathway?ko04670
MIM	300481	http://www.ncbi.nlm.nih.gov/omim/300481
MIM	300645	http://www.ncbi.nlm.nih.gov/omim/300645
MIM	306400	http://www.ncbi.nlm.nih.gov/omim/306400
MINT	MINT-191276	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-191276
OMA	VKFFYTR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VKFFYTR
Orphanet	319623	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=319623
Orphanet	379	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=379
OrthoDB	EOG091G09RV	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G09RV
PDB	3A1F	http://www.ebi.ac.uk/pdbe-srv/view/entry/3A1F
PDBsum	3A1F	http://www.ebi.ac.uk/pdbsum/3A1F
PRINTS	PR00466	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00466
PROSITE	PS51384	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51384
PSORT	swissprot:CY24B_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CY24B_HUMAN
PSORT-B	swissprot:CY24B_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CY24B_HUMAN
PSORT2	swissprot:CY24B_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CY24B_HUMAN
PeroxiBase	5962	http://peroxibase.toulouse.inra.fr/listing.php?action=view&id=5962
Pfam	PF01794	http://pfam.xfam.org/family/PF01794
Pfam	PF08022	http://pfam.xfam.org/family/PF08022
Pfam	PF08030	http://pfam.xfam.org/family/PF08030
PharmGKB	PA27076	http://www.pharmgkb.org/do/serve?objId=PA27076&objCls=Gene
Phobius	swissprot:CY24B_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CY24B_HUMAN
PhylomeDB	P04839	http://phylomedb.org/?seqid=P04839
ProteinModelPortal	P04839	http://www.proteinmodelportal.org/query/uniprot/P04839
PubMed	10089913	http://www.ncbi.nlm.nih.gov/pubmed/10089913
PubMed	10578014	http://www.ncbi.nlm.nih.gov/pubmed/10578014
PubMed	10914676	http://www.ncbi.nlm.nih.gov/pubmed/10914676
PubMed	11462241	http://www.ncbi.nlm.nih.gov/pubmed/11462241
PubMed	11997083	http://www.ncbi.nlm.nih.gov/pubmed/11997083
PubMed	12139950	http://www.ncbi.nlm.nih.gov/pubmed/12139950
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15338276	http://www.ncbi.nlm.nih.gov/pubmed/15338276
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	1710153	http://www.ncbi.nlm.nih.gov/pubmed/1710153
PubMed	18773283	http://www.ncbi.nlm.nih.gov/pubmed/18773283
PubMed	19028840	http://www.ncbi.nlm.nih.gov/pubmed/19028840
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	21278736	http://www.ncbi.nlm.nih.gov/pubmed/21278736
PubMed	22125116	http://www.ncbi.nlm.nih.gov/pubmed/22125116
PubMed	23910690	http://www.ncbi.nlm.nih.gov/pubmed/23910690
PubMed	2425263	http://www.ncbi.nlm.nih.gov/pubmed/2425263
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	2556453	http://www.ncbi.nlm.nih.gov/pubmed/2556453
PubMed	3600768	http://www.ncbi.nlm.nih.gov/pubmed/3600768
PubMed	3600769	http://www.ncbi.nlm.nih.gov/pubmed/3600769
PubMed	7927345	http://www.ncbi.nlm.nih.gov/pubmed/7927345
PubMed	8101486	http://www.ncbi.nlm.nih.gov/pubmed/8101486
PubMed	8182143	http://www.ncbi.nlm.nih.gov/pubmed/8182143
PubMed	8916969	http://www.ncbi.nlm.nih.gov/pubmed/8916969
PubMed	9111587	http://www.ncbi.nlm.nih.gov/pubmed/9111587
PubMed	9224653	http://www.ncbi.nlm.nih.gov/pubmed/9224653
PubMed	9585602	http://www.ncbi.nlm.nih.gov/pubmed/9585602
PubMed	9667376	http://www.ncbi.nlm.nih.gov/pubmed/9667376
PubMed	9790760	http://www.ncbi.nlm.nih.gov/pubmed/9790760
PubMed	9794433	http://www.ncbi.nlm.nih.gov/pubmed/9794433
PubMed	9856476	http://www.ncbi.nlm.nih.gov/pubmed/9856476
PubMed	9888386	http://www.ncbi.nlm.nih.gov/pubmed/9888386
Reactome	R-HSA-1222556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1222556
Reactome	R-HSA-1236973	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1236973
Reactome	R-HSA-3299685	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3299685
Reactome	R-HSA-4420097	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-4420097
Reactome	R-HSA-5668599	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5668599
Reactome	R-HSA-6798695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6798695
RefSeq	NP_000388	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000388
SMR	P04839	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P04839
STRING	9606.ENSP00000367851	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000367851&targetmode=cogs
SUPFAM	SSF63380	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63380
TCDB	5.B.1.1	http://www.tcdb.org/search/result.php?tc=5.B.1.1
UCSC	uc004ddr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004ddr&org=rat
UniGene	Hs.292356	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.292356
UniProtKB	CY24B_HUMAN	http://www.uniprot.org/uniprot/CY24B_HUMAN
UniProtKB-AC	P04839	http://www.uniprot.org/uniprot/P04839
charge	swissprot:CY24B_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CY24B_HUMAN
eggNOG	ENOG410XNZY	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNZY
eggNOG	KOG0039	http://eggnogapi.embl.de/nog_data/html/tree/KOG0039
epestfind	swissprot:CY24B_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CY24B_HUMAN
garnier	swissprot:CY24B_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CY24B_HUMAN
helixturnhelix	swissprot:CY24B_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CY24B_HUMAN
hmoment	swissprot:CY24B_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CY24B_HUMAN
iep	swissprot:CY24B_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CY24B_HUMAN
inforesidue	swissprot:CY24B_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CY24B_HUMAN
neXtProt	NX_P04839	http://www.nextprot.org/db/entry/NX_P04839
octanol	swissprot:CY24B_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CY24B_HUMAN
pepcoil	swissprot:CY24B_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CY24B_HUMAN
pepdigest	swissprot:CY24B_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CY24B_HUMAN
pepinfo	swissprot:CY24B_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CY24B_HUMAN
pepnet	swissprot:CY24B_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CY24B_HUMAN
pepstats	swissprot:CY24B_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CY24B_HUMAN
pepwheel	swissprot:CY24B_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CY24B_HUMAN
pepwindow	swissprot:CY24B_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CY24B_HUMAN
sigcleave	swissprot:CY24B_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CY24B_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AT2B1_HUMAN	Event=Alternative splicing; Named isoforms=6; Name=D; Synonyms=CIV, hPMCA1d; IsoId=P20020-1; Sequence=Displayed; Name=A; Synonyms=CII, hPMCA1a; IsoId=P20020-2; Sequence=VSP_000375; Name=B; Synonyms=CI, hPMCA1b; IsoId=P20020-3; Sequence=VSP_000373; Name=C; Synonyms=CIII, hPMCA1c; IsoId=P20020-4; Sequence=VSP_000374; Name=E; Synonyms=CV; IsoId=P20020-5; Sequence=VSP_000376; Name=K; IsoId=P20020-6; Sequence=VSP_000372, VSP_000373; 
# AltName	AT2B1_HUMAN	Plasma membrane calcium ATPase isoform 1
# AltName	AT2B1_HUMAN	Plasma membrane calcium pump isoform 1
# BRENDA	3.6.3	2681
# BioGrid	106980	36
# CATALYTIC ACTIVITY	AT2B1_HUMAN	ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2). 
# CCDS	CCDS41817	-. [P20020-2]
# CCDS	CCDS9035	-. [P20020-3]
# ChiTaRS	ATP2B1	human
# DOMAIN	AT2B1_HUMAN	The calmodulin-binding subdomain B is different in the different splice variants and shows pH dependent calmodulin binding properties in isoforms A, C, D and E. 
# Ensembl	ENST00000261173	ENSP00000261173; ENSG00000070961. [P20020-3]
# Ensembl	ENST00000359142	ENSP00000352054; ENSG00000070961. [P20020-2]
# Ensembl	ENST00000428670	ENSP00000392043; ENSG00000070961. [P20020-3]
# ExpressionAtlas	P20020	baseline and differential
# FUNCTION	AT2B1_HUMAN	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. 
# GO_component	GO:0005634	nucleus; IDA:HPA.
# GO_component	GO:0005886	plasma membrane; IDA:HPA.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0009898	cytoplasmic side of plasma membrane; IEA:Ensembl.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:Ensembl.
# GO_component	GO:0016324	apical plasma membrane; IEA:Ensembl.
# GO_component	GO:0032591	dendritic spine membrane; IEA:Ensembl.
# GO_component	GO:0032809	neuronal cell body membrane; IEA:Ensembl.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IBA:GO_Central.
# GO_component	GO:0045121	membrane raft; IEA:Ensembl.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005388	calcium-transporting ATPase activity; TAS:Reactome.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0030165	PDZ domain binding; IBA:GO_Central.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0003407	neural retina development; IEA:Ensembl.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006874	cellular calcium ion homeostasis; IBA:GO_Central.
# GO_process	GO:0007420	brain development; IEA:Ensembl.
# GO_process	GO:0007568	aging; IEA:Ensembl.
# GO_process	GO:0009409	response to cold; IEA:Ensembl.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0071305	cellular response to vitamin D; IEA:Ensembl.
# GO_process	GO:0071386	cellular response to corticosterone stimulus; IEA:Ensembl.
# GO_process	GO:1901660	calcium ion export; IEA:Ensembl.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007568	aging
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.1110.10	-; 1.
# Gene3D	2.70.150.10	-; 2.
# Gene3D	3.40.1110.10	-; 1.
# Genevisible	P20020	HS
# HGNC	HGNC:814	ATP2B1
# IntAct	P20020	24
# InterPro	IPR001757	P_typ_ATPase
# InterPro	IPR004014	ATPase_P-typ_cation-transptr_N
# InterPro	IPR006068	ATPase_P-typ_cation-transptr_C
# InterPro	IPR006408	P-type_ATPase_IIB
# InterPro	IPR008250	ATPase_P-typ_transduc_dom_A
# InterPro	IPR018303	ATPase_P-typ_P_site
# InterPro	IPR022141	ATP_Ca_trans_C
# InterPro	IPR023214	HAD-like_dom
# InterPro	IPR023298	ATPase_P-typ_TM_dom
# InterPro	IPR023299	ATPase_P-typ_cyto_domN
# InterPro	IPR030319	ATP2B1/4
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04970	Salivary secretion
# KEGG_Pathway	ko04972	Pancreatic secretion
# MIM	108731	gene
# Organism	AT2B1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR24093:SF276	PTHR24093:SF276; 3
# PIR	A30802	A30802
# PIR	E49570	E49570
# PIR	I55491	I55491
# PIR	I70165	I70165
# PROSITE	PS00154	ATPASE_E1_E2
# Pfam	PF00122	E1-E2_ATPase; 2
# Pfam	PF00689	Cation_ATPase_C
# Pfam	PF00690	Cation_ATPase_N
# Pfam	PF12424	ATP_Ca_trans_C; 2
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-418359	Reduction of cytosolic Ca++ levels
# Reactome	R-HSA-5578775	Ion homeostasis
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	AT2B1_HUMAN	Plasma membrane calcium-transporting ATPase 1
# RefSeq	NP_001001323	NM_001001323.1. [P20020-2]
# RefSeq	NP_001673	NM_001682.2. [P20020-3]
# RefSeq	XP_011536709	XM_011538407.2. [P20020-4]
# RefSeq	XP_016874847	XM_017019358.1. [P20020-6]
# SIMILARITY	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. {ECO	0000305}.
# SMART	SM00831	Cation_ATPase_N
# SUBCELLULAR LOCATION	AT2B1_HUMAN	Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	AT2B1_HUMAN	Interacts with PDZD11. Interacts with SLC35G1 and STIM1. {ECO 0000269|PubMed 12763866, ECO 0000269|PubMed 22084111}. 
# SUPFAM	SSF56784	SSF56784; 2
# SUPFAM	SSF81660	SSF81660
# TCDB	3.A.3.2.25	the p-type atpase (p-atpase) superfamily
# TIGRFAMs	TIGR01494	ATPase_P-type; 3
# TIGRFAMs	TIGR01517	ATPase-IIB_Ca
# TISSUE SPECIFICITY	AT2B1_HUMAN	Isoform B is ubiquitously expressed. Isoform C is found in brain cortex, skeletal muscle and heart muscle. Isoform D has only been found in fetal skeletal muscle. Isoform K has been found in small intestine and liver. 
# UCSC	uc001tbg	human. [P20020-1]
# eggNOG	ENOG410XNNC	LUCA
# eggNOG	KOG0204	Eukaryota
BLAST	swissprot:AT2B1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AT2B1_HUMAN
BioCyc	ZFISH:HS01020-MONOMER	http://biocyc.org/getid?id=ZFISH:HS01020-MONOMER
COXPRESdb	490	http://coxpresdb.jp/data/gene/490.shtml
CleanEx	HS_ATP2B1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP2B1
DOI	10.1002/jbmr.5650080415	http://dx.doi.org/10.1002/jbmr.5650080415
DOI	10.1007/s001090050088	http://dx.doi.org/10.1007/s001090050088
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/bi00162a016	http://dx.doi.org/10.1021/bi00162a016
DOI	10.1021/bi00436a020	http://dx.doi.org/10.1021/bi00436a020
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.1117231108	http://dx.doi.org/10.1073/pnas.1117231108
DOI	10.1073/pnas.86.18.6908	http://dx.doi.org/10.1073/pnas.86.18.6908
DOI	10.1111/j.1749-6632.2003.tb07230.x	http://dx.doi.org/10.1111/j.1749-6632.2003.tb07230.x
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EC_number	EC:3.6.3.8	http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.8
EMBL	J04027	http://www.ebi.ac.uk/ena/data/view/J04027
EMBL	L14561	http://www.ebi.ac.uk/ena/data/view/L14561
EMBL	L14561	http://www.ebi.ac.uk/ena/data/view/L14561
EMBL	M25824	http://www.ebi.ac.uk/ena/data/view/M25824
EMBL	M25824	http://www.ebi.ac.uk/ena/data/view/M25824
EMBL	M25824	http://www.ebi.ac.uk/ena/data/view/M25824
EMBL	M95541	http://www.ebi.ac.uk/ena/data/view/M95541
EMBL	M95542	http://www.ebi.ac.uk/ena/data/view/M95542
EMBL	S49852	http://www.ebi.ac.uk/ena/data/view/S49852
EMBL	U15686	http://www.ebi.ac.uk/ena/data/view/U15686
EMBL	U15687	http://www.ebi.ac.uk/ena/data/view/U15687
ENZYME	3.6.3.8	http://enzyme.expasy.org/EC/3.6.3.8
Ensembl	ENST00000261173	http://www.ensembl.org/id/ENST00000261173
Ensembl	ENST00000359142	http://www.ensembl.org/id/ENST00000359142
Ensembl	ENST00000428670	http://www.ensembl.org/id/ENST00000428670
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0009898	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009898
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0032591	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032591
GO_component	GO:0032809	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032809
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_component	GO:0045121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045121
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005388	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005388
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0030165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030165
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0003407	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003407
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874
GO_process	GO:0007420	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007420
GO_process	GO:0007568	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007568
GO_process	GO:0009409	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009409
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0071305	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071305
GO_process	GO:0071386	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071386
GO_process	GO:1901660	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901660
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007568	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007568
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.1110.10	http://www.cathdb.info/version/latest/superfamily/1.20.1110.10
Gene3D	2.70.150.10	http://www.cathdb.info/version/latest/superfamily/2.70.150.10
Gene3D	3.40.1110.10	http://www.cathdb.info/version/latest/superfamily/3.40.1110.10
GeneCards	ATP2B1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP2B1
GeneID	490	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=490
GeneTree	ENSGT00510000046331	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00510000046331
HGNC	HGNC:814	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:814
HOVERGEN	HBG061286	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG061286&db=HOVERGEN
HPA	CAB005605	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB005605
HPA	HPA011166	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA011166
HPA	HPA012945	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA012945
InParanoid	P20020	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P20020
IntAct	P20020	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P20020*
IntEnz	3.6.3.8	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.8
InterPro	IPR001757	http://www.ebi.ac.uk/interpro/entry/IPR001757
InterPro	IPR004014	http://www.ebi.ac.uk/interpro/entry/IPR004014
InterPro	IPR006068	http://www.ebi.ac.uk/interpro/entry/IPR006068
InterPro	IPR006408	http://www.ebi.ac.uk/interpro/entry/IPR006408
InterPro	IPR008250	http://www.ebi.ac.uk/interpro/entry/IPR008250
InterPro	IPR018303	http://www.ebi.ac.uk/interpro/entry/IPR018303
InterPro	IPR022141	http://www.ebi.ac.uk/interpro/entry/IPR022141
InterPro	IPR023214	http://www.ebi.ac.uk/interpro/entry/IPR023214
InterPro	IPR023298	http://www.ebi.ac.uk/interpro/entry/IPR023298
InterPro	IPR023299	http://www.ebi.ac.uk/interpro/entry/IPR023299
InterPro	IPR030319	http://www.ebi.ac.uk/interpro/entry/IPR030319
Jabion	490	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=490
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:490	http://www.genome.jp/dbget-bin/www_bget?hsa:490
KEGG_Orthology	KO:K05850	http://www.genome.jp/dbget-bin/www_bget?KO:K05850
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04970	http://www.genome.jp/kegg-bin/show_pathway?ko04970
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
MIM	108731	http://www.ncbi.nlm.nih.gov/omim/108731
MINT	MINT-5004114	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5004114
OMA	IWELAWI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IWELAWI
PANTHER	PTHR24093:SF276	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24093:SF276
PROSITE	PS00154	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00154
PSORT	swissprot:AT2B1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AT2B1_HUMAN
PSORT-B	swissprot:AT2B1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AT2B1_HUMAN
PSORT2	swissprot:AT2B1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AT2B1_HUMAN
Pfam	PF00122	http://pfam.xfam.org/family/PF00122
Pfam	PF00689	http://pfam.xfam.org/family/PF00689
Pfam	PF00690	http://pfam.xfam.org/family/PF00690
Pfam	PF12424	http://pfam.xfam.org/family/PF12424
PharmGKB	PA25107	http://www.pharmgkb.org/do/serve?objId=PA25107&objCls=Gene
Phobius	swissprot:AT2B1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AT2B1_HUMAN
PhylomeDB	P20020	http://phylomedb.org/?seqid=P20020
ProteinModelPortal	P20020	http://www.proteinmodelportal.org/query/uniprot/P20020
PubMed	12763866	http://www.ncbi.nlm.nih.gov/pubmed/12763866
PubMed	1332771	http://www.ncbi.nlm.nih.gov/pubmed/1332771
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	1827443	http://www.ncbi.nlm.nih.gov/pubmed/1827443
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	22084111	http://www.ncbi.nlm.nih.gov/pubmed/22084111
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	2528729	http://www.ncbi.nlm.nih.gov/pubmed/2528729
PubMed	2548572	http://www.ncbi.nlm.nih.gov/pubmed/2548572
PubMed	2844759	http://www.ncbi.nlm.nih.gov/pubmed/2844759
PubMed	7694502	http://www.ncbi.nlm.nih.gov/pubmed/7694502
PubMed	7989379	http://www.ncbi.nlm.nih.gov/pubmed/7989379
PubMed	8245032	http://www.ncbi.nlm.nih.gov/pubmed/8245032
PubMed	8386431	http://www.ncbi.nlm.nih.gov/pubmed/8386431
PubMed	8396145	http://www.ncbi.nlm.nih.gov/pubmed/8396145
PubMed	9020386	http://www.ncbi.nlm.nih.gov/pubmed/9020386
Reactome	R-HSA-418359	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418359
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_001001323	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001001323
RefSeq	NP_001673	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001673
RefSeq	XP_011536709	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011536709
RefSeq	XP_016874847	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016874847
SMART	SM00831	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00831
STRING	9606.ENSP00000261173	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000261173&targetmode=cogs
SUPFAM	SSF56784	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784
SUPFAM	SSF81660	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81660
TCDB	3.A.3.2.25	http://www.tcdb.org/search/result.php?tc=3.A.3.2.25
TIGRFAMs	TIGR01494	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01494
TIGRFAMs	TIGR01517	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01517
UCSC	uc001tbg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001tbg&org=rat
UniGene	Hs.506276	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.506276
UniProtKB	AT2B1_HUMAN	http://www.uniprot.org/uniprot/AT2B1_HUMAN
UniProtKB-AC	P20020	http://www.uniprot.org/uniprot/P20020
charge	swissprot:AT2B1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AT2B1_HUMAN
eggNOG	ENOG410XNNC	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNNC
eggNOG	KOG0204	http://eggnogapi.embl.de/nog_data/html/tree/KOG0204
epestfind	swissprot:AT2B1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AT2B1_HUMAN
garnier	swissprot:AT2B1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AT2B1_HUMAN
helixturnhelix	swissprot:AT2B1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AT2B1_HUMAN
hmoment	swissprot:AT2B1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AT2B1_HUMAN
iep	swissprot:AT2B1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AT2B1_HUMAN
inforesidue	swissprot:AT2B1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AT2B1_HUMAN
neXtProt	NX_P20020	http://www.nextprot.org/db/entry/NX_P20020
octanol	swissprot:AT2B1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AT2B1_HUMAN
pepcoil	swissprot:AT2B1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AT2B1_HUMAN
pepdigest	swissprot:AT2B1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AT2B1_HUMAN
pepinfo	swissprot:AT2B1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AT2B1_HUMAN
pepnet	swissprot:AT2B1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AT2B1_HUMAN
pepstats	swissprot:AT2B1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AT2B1_HUMAN
pepwheel	swissprot:AT2B1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AT2B1_HUMAN
pepwindow	swissprot:AT2B1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AT2B1_HUMAN
sigcleave	swissprot:AT2B1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AT2B1_HUMAN
## Database	ID	URL or Descriptions
# AltName	Inward rectifying potassium channel protein TWIK-1 {ECO:0000303|PubMed	8605869}
# AltName	KCNK1_HUMAN	Potassium channel KCNO1
# AltName	Potassium channel K2P1 {ECO:0000303|PubMed	15820677}
# BIOPHYSICOCHEMICAL PROPERTIES	KCNK1_HUMAN	Kinetic parameters  Note=Has a unit conductance of 34 pS. Both activation and channel closure are very rapid. Is not voltage-gated. The relationship between voltage and current is nearly linear. Has a mean open time of 0.3 msec at a membrane potential of -80 mV, and 1.9 msec at +80 mV (PubMed 8605869). {ECO 0000269|PubMed 19959478, ECO 0000269|PubMed 8605869}; 
# BioGrid	109976	5
# ChiTaRS	KCNK1	human
# DrugBank	DB00308	Ibutilide
# DrugBank	DB00908	Quinidine
# DrugBank	DB01346	Quinidine barbiturate
# ENZYME REGULATION	KCNK1_HUMAN	Inhibited by Ba(2+) ions and quinidine (PubMed 8605869). Inhibited by quinine (PubMed 8605869, PubMed 21653227). Is slightly inhibited by 10 mM tetraethylammonium (TEA), and only marginally inhibited by 4- aminopyridine, charybdotoxin and dendrotoxin (PubMed 8605869). Lowering the extracellular pH to below 6.5 transiently activates the channel, and then inhibits channel activity (PubMed 15820677, PubMed 22431633). Inhibited when the intracellular pH is decreased down to pH 6.0, but this may be due to indirect effects (PubMed 8605869). {ECO 0000269|PubMed 15820677, ECO 0000269|PubMed 21653227, ECO 0000269|PubMed 22431633, ECO 0000269|PubMed 8605869}. 
# Ensembl	ENST00000366621	ENSP00000355580; ENSG00000135750
# ExpressionAtlas	O00180	baseline and differential
# FUNCTION	KCNK1_HUMAN	Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues (PubMed 15820677, PubMed 21653227). Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium (PubMed 21653227, PubMed 22431633). The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel (PubMed 8605869, PubMed 8978667, PubMed 15820677, PubMed 21653227, PubMed 22431633, PubMed 23169818, PubMed 25001086). Channel activity is modulated by activation of serotonin receptors (By similarity). Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes (By similarity). Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity (PubMed 23169818). Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane- sensitive currents (PubMed 23169818). Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential (By similarity). Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability (By similarity). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity). Required for normal ion and water transport in the kidney (By similarity). Contributes to the regulation of the resting membrane potential of pancreatic beta cells (By similarity). The low channel activity of homodimeric KCNK1 may be due to sumoylation (PubMed 15820677, PubMed 20498050, PubMed 23169818). The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling endosomes (PubMed 19959478). {ECO 0000250|UniProtKB O08581, ECO 0000250|UniProtKB Q9Z2T2, ECO 0000269|PubMed 15820677, ECO 0000269|PubMed 17693262, ECO 0000269|PubMed 19959478, ECO 0000269|PubMed 20498050, ECO 0000269|PubMed 21653227, ECO 0000269|PubMed 22282804, ECO 0000269|PubMed 22431633, ECO 0000269|PubMed 23169818, ECO 0000269|PubMed 25001086, ECO 0000269|PubMed 8605869, ECO 0000269|PubMed 8978667}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0008076	voltage-gated potassium channel complex; TAS:ProtInc.
# GO_component	GO:0016021	integral component of membrane; IDA:UniProtKB.
# GO_component	GO:0016023	cytoplasmic, membrane-bounded vesicle; IEA:UniProtKB-SubCell.
# GO_component	GO:0016324	apical plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030425	dendrite; IEA:UniProtKB-SubCell.
# GO_component	GO:0031526	brush border membrane; IEA:Ensembl.
# GO_component	GO:0034705	potassium channel complex; IDA:UniProtKB.
# GO_component	GO:0043204	perikaryon; IEA:UniProtKB-SubCell.
# GO_component	GO:0045202	synapse; IEA:UniProtKB-SubCell.
# GO_component	GO:0055037	recycling endosome; IEA:UniProtKB-SubCell.
# GO_component	GO:1902937	inward rectifier potassium channel complex; IEA:Ensembl.
# GO_function	GO:0005242	inward rectifier potassium channel activity; TAS:ProtInc.
# GO_function	GO:0005267	potassium channel activity; IDA:UniProtKB.
# GO_function	GO:0005272	sodium channel activity; IDA:UniProtKB.
# GO_function	GO:0022841	potassium ion leak channel activity; IDA:UniProtKB.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0030322	stabilization of membrane potential; IBA:GO_Central.
# GO_process	GO:0035094	response to nicotine; IEA:Ensembl.
# GO_process	GO:0035725	sodium ion transmembrane transport; IDA:UniProtKB.
# GO_process	GO:0060075	regulation of resting membrane potential; IMP:UniProtKB.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:0071805	potassium ion transmembrane transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	O00180	HS
# HGNC	HGNC:6272	KCNK1
# IntAct	O00180	2
# InterPro	IPR001779	2pore_dom_K_chnl_TWIK1
# InterPro	IPR003092	2pore_dom_K_chnl_TASK
# InterPro	IPR003280	2pore_dom_K_chnl
# InterPro	IPR005408	2pore_dom_K_chnl_TWIK
# InterPro	IPR013099	K_chnl_dom
# KEGG_Brite	ko04040	Ion channels
# MIM	601745	gene
# MISCELLANEOUS	KCNK1_HUMAN	When the external K(+) concentration is lowered to subphysiological levels, it takes several minutes till the channel has reached a new, stable state characterized by increased Na(+) permeability (PubMed 21653227). Likewise, when the external pH is lowered to values below 6.5, it takes several minutes till the channel has reached a new, stable state characterized by increased Na(+) permeability (PubMed 22431633). When raising the K(+) concentration back to 5 mM, it takes 40 to 70 minutes for the channel to regain its original selectivity for K(+) (PubMed 21653227). Likewise, it takes more that 25 minutes for the channel to regain its original K(+) selectivity when the pH is raised back to 7.4 (PubMed 22431633). {ECO 0000269|PubMed 21653227, ECO 0000269|PubMed 22431633}. 
# Organism	KCNK1_HUMAN	Homo sapiens (Human)
# PDB	3UKM	X-ray; 3.40 A; A/B/C/D=19-288
# PIR	S65566	S65566
# PIRSF	PIRSF038061	K_channel_subfamily_K_type
# PRINTS	PR01096	TWIK1CHANNEL
# PRINTS	PR01333	2POREKCHANEL
# PRINTS	PR01586	TWIKCHANNEL
# PTM	KCNK1_HUMAN	Sumoylation is controversial. Sumoylated by UBE2I (PubMed 15820677). Not sumoylated when expressed in xenopus oocytes or mammalian cells (PubMed 17693262). Sumoylation inactivates the channel, but does not interfere with expression at the cell membrane (PubMed 15820677). Sumoylation of a single subunit is sufficient to silence the dimeric channel (PubMed 20498050, PubMed 23169818). Sumoylation of KCNK1 is sufficient to silence heterodimeric channels formed by KCNK1 and KCNK3 or KCNK9 (PubMed 23169818). Desumoylated by SENP1; this activates the channel (PubMed 15820677, PubMed 20498050, PubMed 23169818). Desumoylated by SENP1; this strongly increases halothane-mediated activation of heterodimeric channels formed with KCNK9 (PubMed 23169818). SENP1 treatment has no effect (PubMed 17693262). {ECO 0000269|PubMed 15820677, ECO 0000269|PubMed 17693262, ECO 0000269|PubMed 20498050, ECO 0000269|PubMed 23169818}. 
# Pfam	PF07885	Ion_trans_2; 2
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-1299308	Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)
# Reactome	R-HSA-5576886	Phase 4 - resting membrane potential
# RecName	KCNK1_HUMAN	Potassium channel subfamily K member 1
# RefSeq	NP_002236	NM_002245.3
# SIMILARITY	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCNK1_HUMAN	Cell membrane {ECO 0000269|PubMed 15820677, ECO 0000269|PubMed 17693262, ECO 0000269|PubMed 20498050, ECO 0000269|PubMed 21653227, ECO 0000269|PubMed 22282804, ECO 0000269|PubMed 22431633, ECO 0000269|PubMed 23169818, ECO 0000269|PubMed 25001086, ECO 0000269|PubMed 8605869, ECO 0000269|PubMed 8978667}; Multi-pass membrane protein {ECO 0000269|PubMed 22282804, ECO 0000269|PubMed 8978667, ECO 0000305}. Recycling endosome {ECO 0000269|PubMed 19959478}. Cell junction, synapse {ECO 0000250|UniProtKB Q9Z2T2}. Cytoplasmic vesicle {ECO 0000250|UniProtKB O08581}. Perikaryon {ECO 0000250|UniProtKB O08581}. Cell projection, dendrite {ECO 0000250|UniProtKB O08581}. Cell projection {ECO 0000250|UniProtKB O08581}. Apical cell membrane {ECO 0000269|PubMed 21964404}; Multi-pass membrane protein {ECO 0000305}. Note=The heterodimer with KCNK2 is detected at the astrocyte cell membrane. Not detected at the astrocyte cell membrane when KCNK2 is absent. Detected on neuronal cell bodies, and to a lesser degree on neuronal cell projections. Detected on hippocampus dentate gyrus granule cell bodies and to a lesser degree on proximal dendrites. Detected in synaptic membranes. Detected at the apical cell membrane in stria vascularis in the cochlea. Detected at the apical cell membrane of vestibular dark cells situated between the crista and the utricle in the inner ear. Detected at the apical cell membrane in kidney proximal tubule segment S1 and in subapical compartments in segments S1, S2 and S3. Predominantly in cytoplasmic structures in kidney distal convoluted tubules and collecting ducts (By similarity). Detected at the apical cell membrane of bronchial epithelial cells (PubMed 21964404). {ECO 0000250|UniProtKB O08581, ECO 0000250|UniProtKB Q9Z2T2, ECO 0000269|PubMed 21964404}. 
# SUBUNIT	KCNK1_HUMAN	Homodimer; disulfide-linked (PubMed 8978667, PubMed 22282804). Heterodimer with KCNK2; disulfide-linked (By similarity). In astrocytes, forms mostly heterodimeric potassium channels with KCNK2, with only a minor proportion of functional channels containing homodimeric KCNK1 (By similarity). Interacts with KCNK3 and KCNK9, forming functional heterodimeric channels (PubMed 23169818). Interacts with GNG4 (By similarity). Identified in a complex with PSD and ARF6; interacts only with PSD that is bound to ARF6 (By similarity). Interacts with UBE2I (PubMed 15820677). {ECO 0000250|UniProtKB O08581, ECO 0000269|PubMed 15820677, ECO 0000269|PubMed 22282804, ECO 0000269|PubMed 23169818, ECO 0000269|PubMed 8978667}. 
# TISSUE SPECIFICITY	KCNK1_HUMAN	Detected in bronchial epithelial cells (PubMed 21964404). Detected in heart left atrium and left ventricle (PubMed 17478540). Detected in cardiac myocytes (at protein level) (PubMed 21653227). Widely expressed with high levels in heart, brain and kidney, and lower levels in colon, ovary, placenta, lung and liver (PubMed 8605869, PubMed 9362344). Highly expressed in cerebellum, and detected at lower levels in amygdala, caudate nucleus, brain cortex, hippocampus, putamen, substantia nigra, thalamus, dorsal root ganglion, spinal cord, pituitary, heart, kidney, lung, placenta, pancreas, stomach, small intestine, uterus and prostate (PubMed 11165377). Detected in right and left heart ventricle and atrium, and in heart Purkinje fibers (PubMed 17478540). Detected in bronchial epithelial cells (PubMed 21964404). {ECO 0000269|PubMed 11165377, ECO 0000269|PubMed 17478540, ECO 0000269|PubMed 21653227, ECO 0000269|PubMed 21964404, ECO 0000269|PubMed 8605869, ECO 0000269|PubMed 9362344}. 
# UCSC	uc010pxo	human
# eggNOG	COG1226	LUCA
# eggNOG	KOG1418	Eukaryota
BLAST	swissprot:KCNK1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNK1_HUMAN
BioCyc	ZFISH:ENSG00000135750-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000135750-MONOMER
COXPRESdb	3775	http://coxpresdb.jp/data/gene/3775.shtml
CleanEx	HS_KCNK1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNK1
DIP	DIP-59532N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-59532N
DOI	10.1007/s00424-014-1631-y	http://dx.doi.org/10.1007/s00424-014-1631-y
DOI	10.1007/s109-1998-8100-0	http://dx.doi.org/10.1007/s109-1998-8100-0
DOI	10.1016/S0169-328X(00)00263-1	http://dx.doi.org/10.1016/S0169-328X(00)00263-1
DOI	10.1016/j.cell.2005.01.019	http://dx.doi.org/10.1016/j.cell.2005.01.019
DOI	10.1016/j.cell.2007.06.012	http://dx.doi.org/10.1016/j.cell.2007.06.012
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ncomms5377	http://dx.doi.org/10.1038/ncomms5377
DOI	10.1073/pnas.1004712107	http://dx.doi.org/10.1073/pnas.1004712107
DOI	10.1073/pnas.1201132109	http://dx.doi.org/10.1073/pnas.1201132109
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1074/jbc.M109.078535	http://dx.doi.org/10.1074/jbc.M109.078535
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1113/jphysiol.2006.126714	http://dx.doi.org/10.1113/jphysiol.2006.126714
DOI	10.1113/jphysiol.2014.287268	http://dx.doi.org/10.1113/jphysiol.2014.287268
DOI	10.1126/science.1213274	http://dx.doi.org/10.1126/science.1213274
DOI	10.1126/scisignal.2001726	http://dx.doi.org/10.1126/scisignal.2001726
DOI	10.1126/scisignal.2003431	http://dx.doi.org/10.1126/scisignal.2003431
DOI	10.1152/ajplung.00102.2011	http://dx.doi.org/10.1152/ajplung.00102.2011
DrugBank	DB00308	http://www.drugbank.ca/drugs/DB00308
DrugBank	DB00908	http://www.drugbank.ca/drugs/DB00908
DrugBank	DB01346	http://www.drugbank.ca/drugs/DB01346
EMBL	AL356357	http://www.ebi.ac.uk/ena/data/view/AL356357
EMBL	BC018051	http://www.ebi.ac.uk/ena/data/view/BC018051
EMBL	CH471098	http://www.ebi.ac.uk/ena/data/view/CH471098
EMBL	U33632	http://www.ebi.ac.uk/ena/data/view/U33632
EMBL	U76996	http://www.ebi.ac.uk/ena/data/view/U76996
EMBL	U90065	http://www.ebi.ac.uk/ena/data/view/U90065
Ensembl	ENST00000366621	http://www.ensembl.org/id/ENST00000366621
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016023	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016023
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0031526	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031526
GO_component	GO:0034705	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034705
GO_component	GO:0043204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043204
GO_component	GO:0045202	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045202
GO_component	GO:0055037	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055037
GO_component	GO:1902937	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902937
GO_function	GO:0005242	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005242
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_function	GO:0005272	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005272
GO_function	GO:0022841	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022841
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0030322	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030322
GO_process	GO:0035094	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035094
GO_process	GO:0035725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035725
GO_process	GO:0060075	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060075
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	KCNK1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNK1
GeneID	3775	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3775
GeneTree	ENSGT00760000118858	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118858
HGNC	HGNC:6272	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6272
HOGENOM	HOG000286014	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000286014&db=HOGENOM6
HOVERGEN	HBG052237	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052237&db=HOVERGEN
HPA	CAB022588	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB022588
HPA	HPA016049	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA016049
InParanoid	O00180	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O00180
IntAct	O00180	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O00180*
InterPro	IPR001779	http://www.ebi.ac.uk/interpro/entry/IPR001779
InterPro	IPR003092	http://www.ebi.ac.uk/interpro/entry/IPR003092
InterPro	IPR003280	http://www.ebi.ac.uk/interpro/entry/IPR003280
InterPro	IPR005408	http://www.ebi.ac.uk/interpro/entry/IPR005408
InterPro	IPR013099	http://www.ebi.ac.uk/interpro/entry/IPR013099
Jabion	3775	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3775
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3775	http://www.genome.jp/dbget-bin/www_bget?hsa:3775
KEGG_Orthology	KO:K04912	http://www.genome.jp/dbget-bin/www_bget?KO:K04912
MIM	601745	http://www.ncbi.nlm.nih.gov/omim/601745
OMA	KQLRKMF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KQLRKMF
OrthoDB	EOG091G0DIX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0DIX
PDB	3UKM	http://www.ebi.ac.uk/pdbe-srv/view/entry/3UKM
PDBsum	3UKM	http://www.ebi.ac.uk/pdbsum/3UKM
PRINTS	PR01096	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01096
PRINTS	PR01333	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01333
PRINTS	PR01586	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01586
PSORT	swissprot:KCNK1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNK1_HUMAN
PSORT-B	swissprot:KCNK1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNK1_HUMAN
PSORT2	swissprot:KCNK1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNK1_HUMAN
Pfam	PF07885	http://pfam.xfam.org/family/PF07885
PharmGKB	PA219	http://www.pharmgkb.org/do/serve?objId=PA219&objCls=Gene
Phobius	swissprot:KCNK1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNK1_HUMAN
PhylomeDB	O00180	http://phylomedb.org/?seqid=O00180
ProteinModelPortal	O00180	http://www.proteinmodelportal.org/query/uniprot/O00180
PubMed	11165377	http://www.ncbi.nlm.nih.gov/pubmed/11165377
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15820677	http://www.ncbi.nlm.nih.gov/pubmed/15820677
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17478540	http://www.ncbi.nlm.nih.gov/pubmed/17478540
PubMed	17693262	http://www.ncbi.nlm.nih.gov/pubmed/17693262
PubMed	19959478	http://www.ncbi.nlm.nih.gov/pubmed/19959478
PubMed	20498050	http://www.ncbi.nlm.nih.gov/pubmed/20498050
PubMed	21653227	http://www.ncbi.nlm.nih.gov/pubmed/21653227
PubMed	21964404	http://www.ncbi.nlm.nih.gov/pubmed/21964404
PubMed	22282804	http://www.ncbi.nlm.nih.gov/pubmed/22282804
PubMed	22431633	http://www.ncbi.nlm.nih.gov/pubmed/22431633
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23169818	http://www.ncbi.nlm.nih.gov/pubmed/23169818
PubMed	25001086	http://www.ncbi.nlm.nih.gov/pubmed/25001086
PubMed	25339226	http://www.ncbi.nlm.nih.gov/pubmed/25339226
PubMed	25530075	http://www.ncbi.nlm.nih.gov/pubmed/25530075
PubMed	8605869	http://www.ncbi.nlm.nih.gov/pubmed/8605869
PubMed	8978667	http://www.ncbi.nlm.nih.gov/pubmed/8978667
PubMed	9362344	http://www.ncbi.nlm.nih.gov/pubmed/9362344
PubMed	9462864	http://www.ncbi.nlm.nih.gov/pubmed/9462864
Reactome	R-HSA-1299308	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1299308
Reactome	R-HSA-5576886	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576886
RefSeq	NP_002236	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002236
SMR	O00180	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O00180
STRING	9606.ENSP00000355580	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000355580&targetmode=cogs
UCSC	uc010pxo	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010pxo&org=rat
UniGene	Hs.208544	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.208544
UniProtKB	KCNK1_HUMAN	http://www.uniprot.org/uniprot/KCNK1_HUMAN
UniProtKB-AC	O00180	http://www.uniprot.org/uniprot/O00180
charge	swissprot:KCNK1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNK1_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG1418	http://eggnogapi.embl.de/nog_data/html/tree/KOG1418
epestfind	swissprot:KCNK1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNK1_HUMAN
garnier	swissprot:KCNK1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNK1_HUMAN
helixturnhelix	swissprot:KCNK1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNK1_HUMAN
hmoment	swissprot:KCNK1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNK1_HUMAN
iep	swissprot:KCNK1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNK1_HUMAN
inforesidue	swissprot:KCNK1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNK1_HUMAN
neXtProt	NX_O00180	http://www.nextprot.org/db/entry/NX_O00180
octanol	swissprot:KCNK1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNK1_HUMAN
pepcoil	swissprot:KCNK1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNK1_HUMAN
pepdigest	swissprot:KCNK1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNK1_HUMAN
pepinfo	swissprot:KCNK1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNK1_HUMAN
pepnet	swissprot:KCNK1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNK1_HUMAN
pepstats	swissprot:KCNK1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNK1_HUMAN
pepwheel	swissprot:KCNK1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNK1_HUMAN
pepwindow	swissprot:KCNK1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNK1_HUMAN
sigcleave	swissprot:KCNK1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNK1_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCJ16_HUMAN	Inward rectifier K(+) channel Kir5.1
# AltName	KCJ16_HUMAN	Potassium channel, inwardly rectifying subfamily J member 16
# Ensembl	ENST00000283936	ENSP00000283936; ENSG00000153822
# Ensembl	ENST00000392670	ENSP00000376438; ENSG00000153822
# Ensembl	ENST00000392671	ENSP00000376439; ENSG00000153822
# Ensembl	ENST00000589377	ENSP00000465967; ENSG00000153822
# Ensembl	ENST00000615244	ENSP00000479817; ENSG00000153822
# ExpressionAtlas	Q9NPI9	baseline and differential
# FUNCTION	KCJ16_HUMAN	Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules (PubMed 24561201). {ECO 0000305|PubMed 24561201}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0008076	voltage-gated potassium channel complex; NAS:UniProtKB.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0005242	inward rectifier potassium channel activity; NAS:UniProtKB.
# GO_function	GO:0015467	G-protein activated inward rectifier potassium channel activity; TAS:Reactome.
# GO_process	GO:0006813	potassium ion transport; NAS:UniProtKB.
# GO_process	GO:0010107	potassium ion import; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.40.1400	-; 1.
# Genevisible	Q9NPI9	HS
# HGNC	HGNC:6262	KCNJ16
# IntAct	Q9NPI9	2
# InterPro	IPR008061	K_chnl_inward-rec_Kir5
# InterPro	IPR013518	K_chnl_inward-rec_Kir_cyto
# InterPro	IPR014756	Ig_E-set
# InterPro	IPR016449	K_chnl_inward-rec_Kir
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04971	Gastric acid secretion
# MIM	605722	gene
# Organism	KCJ16_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11767	PTHR11767
# PANTHER	PTHR11767:SF24	PTHR11767:SF24
# PIRSF	PIRSF005465	GIRK_kir
# PRINTS	PR01320	KIRCHANNEL
# PRINTS	PR01678	KIR5CHANNEL
# Pfam	PF01007	IRK
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-1296041	Activation of G protein gated Potassium channels
# Reactome	R-HSA-1296067	Potassium transport channels
# Reactome	R-HSA-997272	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
# RecName	KCJ16_HUMAN	Inward rectifier potassium channel 16
# RefSeq	NP_001257351	NM_001270422.1
# RefSeq	NP_001278551	NM_001291622.1
# RefSeq	NP_001278552	NM_001291623.1
# RefSeq	NP_001278553	NM_001291624.1
# RefSeq	NP_001278554	NM_001291625.1
# RefSeq	NP_061128	NM_018658.2
# RefSeq	NP_733937	NM_170741.2
# RefSeq	NP_733938	NM_170742.2
# RefSeq	XP_011523083	XM_011524781.2
# RefSeq	XP_016880102	XM_017024613.1
# SIMILARITY	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ16 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCJ16_HUMAN	Membrane {ECO 0000269|PubMed 24561201}; Multi-pass membrane protein. Basolateral cell membrane {ECO 0000269|PubMed 24561201}. Note=In kidney distal convoluted tubules, located in the basolateral membrane in the presence of KCNJ10. {ECO 0000269|PubMed 24561201}. 
# SUBUNIT	KCJ16_HUMAN	Heterodimer with Kir4.1/KCNJ10; this interaction is required for KCNJ16 localization to the basolateral membrane in kidney cells. As a heterodimer with KCNJ10, may interact with MAGI1; this interaction may facilitate KCNJ10/KCNJ16 potassium channel expression at the basolateral membrane in kidney cells (PubMed 24561201). May form heterodimers with Kir2.1/KCNJ2 (Probable). {ECO 0000269|PubMed 24561201, ECO 0000305|PubMed 11240146}. 
# SUPFAM	SSF81296	SSF81296
# TCDB	1.A.2.1.11	inward rectifier k(+) channel (irk-c) family
# TISSUE SPECIFICITY	KCJ16_HUMAN	Widely expressed, with highest levels in adult and fetal kidney (at protein level). In the kidney, expressed in the proximal and distal convoluted tubules, but not in glomeruli nor collecting ducts. {ECO 0000269|PubMed 11060447, ECO 0000269|PubMed 11240146, ECO 0000269|PubMed 24561201}. 
# UCSC	uc002jin	human
# eggNOG	ENOG410XQ62	LUCA
# eggNOG	KOG3827	Eukaryota
BLAST	swissprot:KCJ16_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCJ16_HUMAN
BioCyc	ZFISH:ENSG00000153822-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000153822-MONOMER
COXPRESdb	3773	http://coxpresdb.jp/data/gene/3773.shtml
CleanEx	HS_KCNJ16	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNJ16
DOI	10.1016/S0014-5793(01)02202-5	http://dx.doi.org/10.1016/S0014-5793(01)02202-5
DOI	10.1016/j.febslet.2014.02.024	http://dx.doi.org/10.1016/j.febslet.2014.02.024
EMBL	AF153814	http://www.ebi.ac.uk/ena/data/view/AF153814
EMBL	AF153815	http://www.ebi.ac.uk/ena/data/view/AF153815
EMBL	AF153816	http://www.ebi.ac.uk/ena/data/view/AF153816
EMBL	AF153817	http://www.ebi.ac.uk/ena/data/view/AF153817
EMBL	AF179353	http://www.ebi.ac.uk/ena/data/view/AF179353
Ensembl	ENST00000283936	http://www.ensembl.org/id/ENST00000283936
Ensembl	ENST00000392670	http://www.ensembl.org/id/ENST00000392670
Ensembl	ENST00000392671	http://www.ensembl.org/id/ENST00000392671
Ensembl	ENST00000589377	http://www.ensembl.org/id/ENST00000589377
Ensembl	ENST00000615244	http://www.ensembl.org/id/ENST00000615244
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_function	GO:0005242	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005242
GO_function	GO:0015467	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015467
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0010107	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010107
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.40.1400	http://www.cathdb.info/version/latest/superfamily/2.60.40.1400
GeneCards	KCNJ16	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNJ16
GeneID	3773	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3773
GeneTree	ENSGT00760000118842	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118842
HGNC	HGNC:6262	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6262
HOGENOM	HOG000237325	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237325&db=HOGENOM6
HOVERGEN	HBG006178	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006178&db=HOVERGEN
HPA	HPA059563	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA059563
InParanoid	Q9NPI9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NPI9
IntAct	Q9NPI9	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NPI9*
InterPro	IPR008061	http://www.ebi.ac.uk/interpro/entry/IPR008061
InterPro	IPR013518	http://www.ebi.ac.uk/interpro/entry/IPR013518
InterPro	IPR014756	http://www.ebi.ac.uk/interpro/entry/IPR014756
InterPro	IPR016449	http://www.ebi.ac.uk/interpro/entry/IPR016449
Jabion	3773	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3773
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3773	http://www.genome.jp/dbget-bin/www_bget?hsa:3773
KEGG_Orthology	KO:K05009	http://www.genome.jp/dbget-bin/www_bget?KO:K05009
KEGG_Pathway	ko04971	http://www.genome.jp/kegg-bin/show_pathway?ko04971
MIM	605722	http://www.ncbi.nlm.nih.gov/omim/605722
PANTHER	PTHR11767	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11767
PANTHER	PTHR11767:SF24	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11767:SF24
PRINTS	PR01320	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01320
PRINTS	PR01678	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01678
PSORT	swissprot:KCJ16_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCJ16_HUMAN
PSORT-B	swissprot:KCJ16_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCJ16_HUMAN
PSORT2	swissprot:KCJ16_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCJ16_HUMAN
Pfam	PF01007	http://pfam.xfam.org/family/PF01007
PharmGKB	PA30047	http://www.pharmgkb.org/do/serve?objId=PA30047&objCls=Gene
Phobius	swissprot:KCJ16_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCJ16_HUMAN
PhylomeDB	Q9NPI9	http://phylomedb.org/?seqid=Q9NPI9
ProteinModelPortal	Q9NPI9	http://www.proteinmodelportal.org/query/uniprot/Q9NPI9
PubMed	11060447	http://www.ncbi.nlm.nih.gov/pubmed/11060447
PubMed	11240146	http://www.ncbi.nlm.nih.gov/pubmed/11240146
PubMed	24561201	http://www.ncbi.nlm.nih.gov/pubmed/24561201
Reactome	R-HSA-1296041	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296041
Reactome	R-HSA-1296067	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296067
Reactome	R-HSA-997272	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-997272
RefSeq	NP_001257351	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001257351
RefSeq	NP_001278551	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001278551
RefSeq	NP_001278552	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001278552
RefSeq	NP_001278553	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001278553
RefSeq	NP_001278554	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001278554
RefSeq	NP_061128	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061128
RefSeq	NP_733937	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_733937
RefSeq	NP_733938	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_733938
RefSeq	XP_011523083	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011523083
RefSeq	XP_016880102	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016880102
SMR	Q9NPI9	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9NPI9
STRING	9606.ENSP00000283936	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000283936&targetmode=cogs
SUPFAM	SSF81296	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81296
TCDB	1.A.2.1.11	http://www.tcdb.org/search/result.php?tc=1.A.2.1.11
UCSC	uc002jin	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002jin&org=rat
UniGene	Hs.463985	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.463985
UniProtKB	KCJ16_HUMAN	http://www.uniprot.org/uniprot/KCJ16_HUMAN
UniProtKB-AC	Q9NPI9	http://www.uniprot.org/uniprot/Q9NPI9
charge	swissprot:KCJ16_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCJ16_HUMAN
eggNOG	ENOG410XQ62	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ62
eggNOG	KOG3827	http://eggnogapi.embl.de/nog_data/html/tree/KOG3827
epestfind	swissprot:KCJ16_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCJ16_HUMAN
garnier	swissprot:KCJ16_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCJ16_HUMAN
helixturnhelix	swissprot:KCJ16_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCJ16_HUMAN
hmoment	swissprot:KCJ16_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCJ16_HUMAN
iep	swissprot:KCJ16_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCJ16_HUMAN
inforesidue	swissprot:KCJ16_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCJ16_HUMAN
neXtProt	NX_Q9NPI9	http://www.nextprot.org/db/entry/NX_Q9NPI9
octanol	swissprot:KCJ16_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCJ16_HUMAN
pepcoil	swissprot:KCJ16_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCJ16_HUMAN
pepdigest	swissprot:KCJ16_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCJ16_HUMAN
pepinfo	swissprot:KCJ16_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCJ16_HUMAN
pepnet	swissprot:KCJ16_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCJ16_HUMAN
pepstats	swissprot:KCJ16_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCJ16_HUMAN
pepwheel	swissprot:KCJ16_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCJ16_HUMAN
pepwindow	swissprot:KCJ16_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCJ16_HUMAN
sigcleave	swissprot:KCJ16_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCJ16_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	117722	70
# ChiTaRS	TIMM13	human
# DOMAIN	TIM13_HUMAN	The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM13 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity). {ECO 0000250}. 
# Ensembl	ENST00000215570	ENSP00000215570; ENSG00000099800
# ExpressionAtlas	Q9Y5L4	baseline and differential
# FUNCTION	TIM13_HUMAN	Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. {ECO 0000269|PubMed 11489896, ECO 0000269|PubMed 15254020}. 
# GO_component	GO:0005730	nucleolus; IDA:HPA.
# GO_component	GO:0005739	mitochondrion; IDA:HPA.
# GO_component	GO:0005743	mitochondrial inner membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0042719	mitochondrial intermembrane space protein transporter complex; TAS:BHF-UCL.
# GO_function	GO:0008270	zinc ion binding; TAS:ProtInc.
# GO_function	GO:0008565	protein transporter activity; IBA:GO_Central.
# GO_process	GO:0006626	protein targeting to mitochondrion; TAS:ProtInc.
# GO_process	GO:0007605	sensory perception of sound; TAS:ProtInc.
# GO_process	GO:0045039	protein import into mitochondrial inner membrane; IBA:GO_Central.
# GO_process	GO:0072321	chaperone-mediated protein transport; TAS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005730	nucleolus
# GOslim_component	GO:0005739	mitochondrion
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006605	protein targeting
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007005	mitochondrion organization
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# GOslim_process	GO:0061024	membrane organization
# Gene3D	1.10.287.810	-; 1.
# Genevisible	Q9Y5L4	HS
# HGNC	HGNC:11816	TIMM13
# IntAct	Q9Y5L4	42
# InterPro	IPR004217	Tim10/DDP_fam_Znf
# MIM	607383	gene
# Organism	TIM13_HUMAN	Homo sapiens (Human)
# Pfam	PF02953	zf-Tim10_DDP
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-1268020	Mitochondrial protein import
# RecName	TIM13_HUMAN	Mitochondrial import inner membrane translocase subunit Tim13
# RefSeq	NP_036590	NM_012458.3
# SIMILARITY	Belongs to the small Tim family. {ECO	0000305}.
# SUBCELLULAR LOCATION	TIM13_HUMAN	Mitochondrion inner membrane {ECO 0000269|PubMed 11489896}; Peripheral membrane protein {ECO 0000269|PubMed 11489896}; Intermembrane side {ECO 0000269|PubMed 11489896}. 
# SUBUNIT	TIM13_HUMAN	Heterohexamer; composed of 3 copies of TIMM8 (TIMM8A or TIMM8B) and 3 copies of TIMM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIMM22. 
# SUPFAM	SSF144122	SSF144122
# TISSUE SPECIFICITY	TIM13_HUMAN	Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle. 
# UCSC	uc002lvx	human
# eggNOG	ENOG41124YI	LUCA
# eggNOG	KOG1733	Eukaryota
BLAST	swissprot:TIM13_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TIM13_HUMAN
BioCyc	ZFISH:ENSG00000099800-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000099800-MONOMER
COXPRESdb	26517	http://coxpresdb.jp/data/gene/26517.shtml
CleanEx	HS_TIMM13	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TIMM13
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/geno.1999.5966	http://dx.doi.org/10.1006/geno.1999.5966
DOI	10.1016/S0014-5793(99)01665-8	http://dx.doi.org/10.1016/S0014-5793(99)01665-8
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1074/jbc.M105313200	http://dx.doi.org/10.1074/jbc.M105313200
DOI	10.1093/hmg/ddh217	http://dx.doi.org/10.1093/hmg/ddh217
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF144700	http://www.ebi.ac.uk/ena/data/view/AF144700
EMBL	AF152351	http://www.ebi.ac.uk/ena/data/view/AF152351
EMBL	AF152352	http://www.ebi.ac.uk/ena/data/view/AF152352
EMBL	BC008607	http://www.ebi.ac.uk/ena/data/view/BC008607
Ensembl	ENST00000215570	http://www.ensembl.org/id/ENST00000215570
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005730
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0042719	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042719
GO_function	GO:0008270	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0006626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006626
GO_process	GO:0007605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007605
GO_process	GO:0045039	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045039
GO_process	GO:0072321	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072321
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005730
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007005
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
Gene3D	1.10.287.810	http://www.cathdb.info/version/latest/superfamily/1.10.287.810
GeneCards	TIMM13	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TIMM13
GeneID	26517	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26517
GeneTree	ENSGT00390000014000	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000014000
HGNC	HGNC:11816	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11816
HOGENOM	HOG000115759	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000115759&db=HOGENOM6
HOVERGEN	HBG079645	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG079645&db=HOVERGEN
HPA	HPA048985	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA048985
InParanoid	Q9Y5L4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y5L4
IntAct	Q9Y5L4	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9Y5L4*
InterPro	IPR004217	http://www.ebi.ac.uk/interpro/entry/IPR004217
Jabion	26517	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=26517
KEGG_Gene	hsa:26517	http://www.genome.jp/dbget-bin/www_bget?hsa:26517
MIM	607383	http://www.ncbi.nlm.nih.gov/omim/607383
MINT	MINT-3087260	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3087260
OMA	CFKKCIN	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CFKKCIN
OrthoDB	EOG091G138S	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G138S
PSORT	swissprot:TIM13_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TIM13_HUMAN
PSORT-B	swissprot:TIM13_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TIM13_HUMAN
PSORT2	swissprot:TIM13_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TIM13_HUMAN
Pfam	PF02953	http://pfam.xfam.org/family/PF02953
PharmGKB	PA36522	http://www.pharmgkb.org/do/serve?objId=PA36522&objCls=Gene
Phobius	swissprot:TIM13_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TIM13_HUMAN
PhylomeDB	Q9Y5L4	http://phylomedb.org/?seqid=Q9Y5L4
ProteinModelPortal	Q9Y5L4	http://www.proteinmodelportal.org/query/uniprot/Q9Y5L4
PubMed	10552927	http://www.ncbi.nlm.nih.gov/pubmed/10552927
PubMed	10611480	http://www.ncbi.nlm.nih.gov/pubmed/10611480
PubMed	11489896	http://www.ncbi.nlm.nih.gov/pubmed/11489896
PubMed	15254020	http://www.ncbi.nlm.nih.gov/pubmed/15254020
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-1268020	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1268020
RefSeq	NP_036590	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_036590
SMR	Q9Y5L4	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9Y5L4
STRING	9606.ENSP00000215570	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000215570&targetmode=cogs
SUPFAM	SSF144122	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF144122
UCSC	uc002lvx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002lvx&org=rat
UniGene	Hs.75056	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.75056
UniProtKB	TIM13_HUMAN	http://www.uniprot.org/uniprot/TIM13_HUMAN
UniProtKB-AC	Q9Y5L4	http://www.uniprot.org/uniprot/Q9Y5L4
charge	swissprot:TIM13_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TIM13_HUMAN
eggNOG	ENOG41124YI	http://eggnogapi.embl.de/nog_data/html/tree/ENOG41124YI
eggNOG	KOG1733	http://eggnogapi.embl.de/nog_data/html/tree/KOG1733
epestfind	swissprot:TIM13_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TIM13_HUMAN
garnier	swissprot:TIM13_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TIM13_HUMAN
helixturnhelix	swissprot:TIM13_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TIM13_HUMAN
hmoment	swissprot:TIM13_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TIM13_HUMAN
iep	swissprot:TIM13_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TIM13_HUMAN
inforesidue	swissprot:TIM13_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TIM13_HUMAN
neXtProt	NX_Q9Y5L4	http://www.nextprot.org/db/entry/NX_Q9Y5L4
octanol	swissprot:TIM13_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TIM13_HUMAN
pepcoil	swissprot:TIM13_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TIM13_HUMAN
pepdigest	swissprot:TIM13_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TIM13_HUMAN
pepinfo	swissprot:TIM13_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TIM13_HUMAN
pepnet	swissprot:TIM13_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TIM13_HUMAN
pepstats	swissprot:TIM13_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TIM13_HUMAN
pepwheel	swissprot:TIM13_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TIM13_HUMAN
pepwindow	swissprot:TIM13_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TIM13_HUMAN
sigcleave	swissprot:TIM13_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TIM13_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	P3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P09131-1; Sequence=Displayed; Name=2; IsoId=P09131-2; Sequence=VSP_043669; Note=No experimental confirmation available.; 
# AltName	P3_HUMAN	Solute carrier family 10 member 3
# BioGrid	113889	2
# CCDS	CCDS14755	-. [P09131-1]
# CCDS	CCDS48195	-. [P09131-2]
# Ensembl	ENST00000263512	ENSP00000263512; ENSG00000126903. [P09131-1]
# Ensembl	ENST00000369649	ENSP00000358663; ENSG00000126903. [P09131-2]
# Ensembl	ENST00000393587	ENSP00000377212; ENSG00000126903. [P09131-1]
# ExpressionAtlas	P09131	baseline and differential
# FUNCTION	P3_HUMAN	The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions. 
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	P3_HUMAN	GO 0008508 bile acid sodium symporter activity; IBA GO_Central.
# GO_process	GO:0032526	response to retinoic acid; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# Genevisible	P09131	HS
# HGNC	HGNC:22979	SLC10A3
# InterPro	IPR002657:BilAc	Na_symport/Acr3
# InterPro	IPR004710:Bilac	Na_transpt
# InterPro	IPR030210	SLC10A3
# KEGG_Brite	ko02001	Solute carrier family
# MIM	312090	gene
# Organism	P3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10361	PTHR10361
# PANTHER	PTHR10361:SF3	PTHR10361:SF3
# PIR	S01696	S01696
# Pfam	PF01758	SBF
# Proteomes	UP000005640	Chromosome X
# RecName	P3_HUMAN	P3 protein
# RefSeq	NP_001135863	NM_001142391.2. [P09131-2]
# RefSeq	NP_001135864	NM_001142392.2. [P09131-1]
# RefSeq	NP_062822	NM_019848.4. [P09131-1]
# RefSeq	XP_011529503	XM_011531201.2. [P09131-1]
# SIMILARITY	Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	P3_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	2.A.28.1:the bile acid	na(+) symporter (bass) family
# TIGRFAMs	TIGR00841	bass
# UCSC	uc004flp	human. [P09131-1]
# eggNOG	COG0385	LUCA
# eggNOG	KOG2718	Eukaryota
BLAST	swissprot:P3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:P3_HUMAN
BioCyc	ZFISH:ENSG00000126903-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000126903-MONOMER
COXPRESdb	8273	http://coxpresdb.jp/data/gene/8273.shtml
CleanEx	HS_SLC10A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC10A3
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1093/hmg/5.5.659	http://dx.doi.org/10.1093/hmg/5.5.659
DOI	10.1093/nar/16.20.9527	http://dx.doi.org/10.1093/nar/16.20.9527
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	BC004966	http://www.ebi.ac.uk/ena/data/view/BC004966
EMBL	BX664739	http://www.ebi.ac.uk/ena/data/view/BX664739
EMBL	BX664739	http://www.ebi.ac.uk/ena/data/view/BX664739
EMBL	CH471172	http://www.ebi.ac.uk/ena/data/view/CH471172
EMBL	CH471172	http://www.ebi.ac.uk/ena/data/view/CH471172
EMBL	CH471172	http://www.ebi.ac.uk/ena/data/view/CH471172
EMBL	L44140	http://www.ebi.ac.uk/ena/data/view/L44140
EMBL	X12458	http://www.ebi.ac.uk/ena/data/view/X12458
Ensembl	ENST00000263512	http://www.ensembl.org/id/ENST00000263512
Ensembl	ENST00000369649	http://www.ensembl.org/id/ENST00000369649
Ensembl	ENST00000393587	http://www.ensembl.org/id/ENST00000393587
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0008508	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008508
GO_process	GO:0032526	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032526
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	SLC10A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC10A3
GeneID	8273	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8273
GeneTree	ENSGT00550000074505	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074505
HGNC	HGNC:22979	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:22979
HOGENOM	HOG000037944	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000037944&db=HOGENOM6
HOVERGEN	HBG002872	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG002872&db=HOVERGEN
HPA	HPA021656	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA021656
InParanoid	P09131	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09131
IntAct	P09131	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09131*
InterPro	IPR002657	http://www.ebi.ac.uk/interpro/entry/IPR002657
InterPro	IPR004710	http://www.ebi.ac.uk/interpro/entry/IPR004710
InterPro	IPR030210	http://www.ebi.ac.uk/interpro/entry/IPR030210
Jabion	8273	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=8273
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:8273	http://www.genome.jp/dbget-bin/www_bget?hsa:8273
KEGG_Orthology	KO:K14343	http://www.genome.jp/dbget-bin/www_bget?KO:K14343
MIM	312090	http://www.ncbi.nlm.nih.gov/omim/312090
MINT	MINT-4722452	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4722452
PANTHER	PTHR10361	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10361
PANTHER	PTHR10361:SF3	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10361:SF3
PSORT	swissprot:P3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:P3_HUMAN
PSORT-B	swissprot:P3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:P3_HUMAN
PSORT2	swissprot:P3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:P3_HUMAN
Pfam	PF01758	http://pfam.xfam.org/family/PF01758
PharmGKB	PA134886398	http://www.pharmgkb.org/do/serve?objId=PA134886398&objCls=Gene
Phobius	swissprot:P3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:P3_HUMAN
PhylomeDB	P09131	http://phylomedb.org/?seqid=P09131
ProteinModelPortal	P09131	http://www.proteinmodelportal.org/query/uniprot/P09131
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	3186440	http://www.ncbi.nlm.nih.gov/pubmed/3186440
PubMed	8733135	http://www.ncbi.nlm.nih.gov/pubmed/8733135
RefSeq	NP_001135863	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001135863
RefSeq	NP_001135864	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001135864
RefSeq	NP_062822	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_062822
RefSeq	XP_011529503	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011529503
SMR	P09131	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09131
STRING	9606.ENSP00000263512	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000263512&targetmode=cogs
TCDB	2.A.28.1	http://www.tcdb.org/search/result.php?tc=2.A.28.1
TIGRFAMs	TIGR00841	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00841
UCSC	uc004flp	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004flp&org=rat
UniGene	Hs.522826	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.522826
UniProtKB	P3_HUMAN	http://www.uniprot.org/uniprot/P3_HUMAN
UniProtKB-AC	P09131	http://www.uniprot.org/uniprot/P09131
charge	swissprot:P3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:P3_HUMAN
eggNOG	COG0385	http://eggnogapi.embl.de/nog_data/html/tree/COG0385
eggNOG	KOG2718	http://eggnogapi.embl.de/nog_data/html/tree/KOG2718
epestfind	swissprot:P3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:P3_HUMAN
garnier	swissprot:P3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:P3_HUMAN
helixturnhelix	swissprot:P3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:P3_HUMAN
hmoment	swissprot:P3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:P3_HUMAN
iep	swissprot:P3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:P3_HUMAN
inforesidue	swissprot:P3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:P3_HUMAN
neXtProt	NX_P09131	http://www.nextprot.org/db/entry/NX_P09131
octanol	swissprot:P3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:P3_HUMAN
pepcoil	swissprot:P3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:P3_HUMAN
pepdigest	swissprot:P3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:P3_HUMAN
pepinfo	swissprot:P3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:P3_HUMAN
pepnet	swissprot:P3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:P3_HUMAN
pepstats	swissprot:P3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:P3_HUMAN
pepwheel	swissprot:P3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:P3_HUMAN
pepwindow	swissprot:P3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:P3_HUMAN
sigcleave	swissprot:P3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:P3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	RYR2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q92736-1; Sequence=Displayed; Name=2; IsoId=Q92736-2; Sequence=VSP_005953; 
# AltName	RYR2_HUMAN	Cardiac muscle ryanodine receptor
# AltName	RYR2_HUMAN	Cardiac muscle ryanodine receptor-calcium release channel
# AltName	RYR2_HUMAN	Type 2 ryanodine receptor
# BioGrid	112174	25
# CCDS	CCDS55691	-. [Q92736-1]
# ChiTaRS	RYR2	human
# DEVELOPMENTAL STAGE	Expressed in myometrium during pregnancy. {ECO:0000269|PubMed	9148749}. 
# DISEASE	RYR2_HUMAN	Arrhythmogenic right ventricular dysplasia, familial, 2 (ARVD2) [MIM 600996]  A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias. {ECO 0000269|PubMed 11159936}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	RYR2_HUMAN	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy (CPVT1) [MIM 604772]  An arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical activity or emotional stress. {ECO 0000269|PubMed 11157710, ECO 0000269|PubMed 12093772, ECO 0000269|PubMed 12106942, ECO 0000269|PubMed 15046072, ECO 0000269|PubMed 15046073, ECO 0000269|PubMed 15466642, ECO 0000269|PubMed 15544015}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	RYR2_HUMAN	The calcium release channel activity resides in the C- terminal region while the remaining part of the protein resides in the cytoplasm. {ECO 0000305}. 
# Ensembl	ENST00000366574	ENSP00000355533; ENSG00000198626. [Q92736-1]
# ExpressionAtlas	Q92736	baseline and differential
# FUNCTION	RYR2_HUMAN	Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. {ECO 0000269|PubMed 10830164, ECO 0000269|PubMed 20056922}. 
# GO_component	GO:0005790	smooth endoplasmic reticulum; IBA:GO_Central.
# GO_component	GO:0005886	plasma membrane; ISS:BHF-UCL.
# GO_component	GO:0014701	junctional sarcoplasmic reticulum membrane; TAS:BHF-UCL.
# GO_component	GO:0016020	membrane; IDA:BHF-UCL.
# GO_component	GO:0016529	sarcoplasmic reticulum; IDA:BHF-UCL.
# GO_component	GO:0030018	Z disc; IDA:BHF-UCL.
# GO_component	GO:0033017	sarcoplasmic reticulum membrane; ISS:BHF-UCL.
# GO_component	GO:0034704	calcium channel complex; IDA:BHF-UCL.
# GO_component	GO:0042383	sarcolemma; IBA:GO_Central.
# GO_component	GO:0043234	protein complex; IDA:MGI.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005219	ryanodine-sensitive calcium-release channel activity; IDA:BHF-UCL.
# GO_function	GO:0005262	calcium channel activity; ISS:UniProtKB.
# GO_function	GO:0005509	calcium ion binding; IBA:GO_Central.
# GO_function	GO:0005516	calmodulin binding; IMP:BHF-UCL.
# GO_function	GO:0015278	calcium-release channel activity; ISS:UniProtKB.
# GO_function	GO:0019899	enzyme binding; IPI:BHF-UCL.
# GO_function	GO:0034236	protein kinase A catalytic subunit binding; IDA:BHF-UCL.
# GO_function	GO:0034237	protein kinase A regulatory subunit binding; IDA:BHF-UCL.
# GO_function	GO:0042802	identical protein binding; IPI:BHF-UCL.
# GO_function	GO:0043924	suramin binding; IMP:BHF-UCL.
# GO_function	GO:0044325	ion channel binding; ISS:BHF-UCL.
# GO_function	GO:0048763	calcium-induced calcium release activity; IDA:BHF-UCL.
# GO_process	GO:0001666	response to hypoxia; ISS:BHF-UCL.
# GO_process	GO:0002027	regulation of heart rate; IMP:BHF-UCL.
# GO_process	GO:0003143	embryonic heart tube morphogenesis; ISS:UniProtKB.
# GO_process	GO:0003220	left ventricular cardiac muscle tissue morphogenesis; ISS:BHF-UCL.
# GO_process	GO:0003300	cardiac muscle hypertrophy; ISS:BHF-UCL.
# GO_process	GO:0005513	detection of calcium ion; IDA:BHF-UCL.
# GO_process	GO:0006816	calcium ion transport; IDA:BHF-UCL.
# GO_process	GO:0006874	cellular calcium ion homeostasis; ISS:UniProtKB.
# GO_process	GO:0010460	positive regulation of heart rate; ISS:BHF-UCL.
# GO_process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; ISS:BHF-UCL.
# GO_process	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling; IMP:BHF-UCL.
# GO_process	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IMP:BHF-UCL.
# GO_process	GO:0014850	response to muscle activity; IMP:BHF-UCL.
# GO_process	GO:0019722	calcium-mediated signaling; ISS:UniProtKB.
# GO_process	GO:0030509	BMP signaling pathway; IEA:Ensembl.
# GO_process	GO:0031000	response to caffeine; IDA:BHF-UCL.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0035584	calcium-mediated signaling using intracellular calcium source; IDA:BHF-UCL.
# GO_process	GO:0035994	response to muscle stretch; IMP:BHF-UCL.
# GO_process	GO:0051209	release of sequestered calcium ion into cytosol; IDA:BHF-UCL.
# GO_process	GO:0051284	positive regulation of sequestering of calcium ion; IDA:BHF-UCL.
# GO_process	GO:0051480	regulation of cytosolic calcium ion concentration; ISS:BHF-UCL.
# GO_process	GO:0051775	response to redox state; IDA:BHF-UCL.
# GO_process	GO:0055117	regulation of cardiac muscle contraction; IMP:BHF-UCL.
# GO_process	GO:0060048	cardiac muscle contraction; IMP:BHF-UCL.
# GO_process	GO:0060070	canonical Wnt signaling pathway; IEA:Ensembl.
# GO_process	GO:0060402	calcium ion transport into cytosol; IDA:BHF-UCL.
# GO_process	GO:0070296	sarcoplasmic reticulum calcium ion transport; TAS:BHF-UCL.
# GO_process	GO:0071313	cellular response to caffeine; ISS:UniProtKB.
# GO_process	GO:0071872	cellular response to epinephrine stimulus; ISS:BHF-UCL.
# GO_process	GO:0072599	establishment of protein localization to endoplasmic reticulum; IDA:BHF-UCL.
# GO_process	GO:0086005	ventricular cardiac muscle cell action potential; ISS:BHF-UCL.
# GO_process	GO:0086029	Purkinje myocyte to ventricular cardiac muscle cell signaling; ISS:BHF-UCL.
# GO_process	GO:0086064	cell communication by electrical coupling involved in cardiac conduction; IC:BHF-UCL.
# GO_process	GO:0097050	type B pancreatic cell apoptotic process; IMP:BHF-UCL.
# GO_process	GO:0098735	positive regulation of the force of heart contraction; IMP:BHF-UCL.
# GO_process	GO:0098904	regulation of AV node cell action potential; IMP:BHF-UCL.
# GO_process	GO:0098907	regulation of SA node cell action potential; IMP:BHF-UCL.
# GO_process	GO:0098910	regulation of atrial cardiac muscle cell action potential; IMP:BHF-UCL.
# GO_process	GO:0098911	regulation of ventricular cardiac muscle cell action potential; IMP:BHF-UCL.
# GO_process	GO:1901896	positive regulation of calcium-transporting ATPase activity; IDA:BHF-UCL.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0008219	cell death
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.10.238.10	-; 1.
# Gene3D	1.25.10.30	-; 1.
# Genevisible	Q92736	HS
# HGNC	HGNC:10484	RYR2
# INDUCTION	By TGFB1. {ECO:0000269|PubMed	9148749}. 
# INTERACTION	RYR2_HUMAN	P62942 FKBP1A; NbExp=2; IntAct=EBI-1170425, EBI-1027571; P68106 FKBP1B; NbExp=5; IntAct=EBI-1170425, EBI-6693977; Q00987 MDM2; NbExp=2; IntAct=EBI-1170425, EBI-389668; 
# IntAct	Q92736	10
# InterPro	IPR000699	RIH_dom
# InterPro	IPR001870	B30.2/SPRY
# InterPro	IPR002048	EF_hand_dom
# InterPro	IPR003032	Ryanodine_rcpt
# InterPro	IPR003877	SPRY_dom
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR009460	Ryanrecept_TM4-6
# InterPro	IPR011992	EF-hand-dom_pair
# InterPro	IPR013320	ConA-like_dom
# InterPro	IPR013333	Ryan_recept
# InterPro	IPR013662	RIH_assoc-dom
# InterPro	IPR014821	Ins145_P3_rcpt
# InterPro	IPR015925	Ryanodine_recept-rel
# InterPro	IPR016093	MIR_motif
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00293	[Cardiovascular disease] Arrhythmogenic right ventricular cardiomyopathy (ARVC)
# KEGG_Disease	H01019	[Cardiovascular disease] Catecholaminergic polymorphic ventricular tachycardia
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko04713	Circadian entrainment
# KEGG_Pathway	ko04972	Pancreatic secretion
# KEGG_Pathway	ko05410	Hypertrophic cardiomyopathy (HCM)
# KEGG_Pathway	ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
# KEGG_Pathway	ko05414	Dilated cardiomyopathy
# MIM	180902	gene
# MIM	600996	phenotype
# MIM	604772	phenotype
# MISCELLANEOUS	Channel activity is modulated by the alkaloid ryanodine that binds to the open Ca-release channel with high affinity. At low concentrations, ryanodine maintains the channel in an open conformation. High ryanodine concentrations inhibit channel activity. Channel activity is regulated by calmodulin (CALM). The calcium release is activated by increased cytoplasmic calcium levels, by nitric oxyde (NO), caffeine and ATP. Channel activity is inhibited by magnesium ions, possibly by competition for calcium binding sites (By similarity). {ECO	0000250}. 
# Organism	RYR2_HUMAN	Homo sapiens (Human)
# Orphanet	293888	Familial isolated arrhythmogenic ventricular dysplasia, left dominant form
# Orphanet	293899	Familial isolated arrhythmogenic ventricular dysplasia, biventricular form
# Orphanet	293910	Familial isolated arrhythmogenic ventricular dysplasia, right dominant form
# Orphanet	3286	Catecholaminergic polymorphic ventricular tachycardia
# PANTHER	PTHR13715	PTHR13715; 5
# PDB	4JKQ	X-ray; 2.39 A; A=1-606
# PIR	S72269	S72269
# PRINTS	PR00795	RYANODINER
# PROSITE	PS50188	B302_SPRY; 3
# PROSITE	PS50919	MIR; 5
# PTM	RYR2_HUMAN	Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2808 and Ser-2814 increases the open probability of the calcium channel. Phosphorylation is increased in failing heart, leading to calcium leaks and increased cytoplasmic Ca(2+) levels. {ECO 0000269|PubMed 10830164, ECO 0000269|PubMed 20056922}. 
# PTM	RYR2_HUMAN	Phosphorylation at Ser-2031 by PKA enhances the response to lumenal calcium. {ECO 0000250}. 
# Pfam	PF00520	Ion_trans
# Pfam	PF00622	SPRY; 3
# Pfam	PF01365	RYDR_ITPR; 2
# Pfam	PF02026	RyR; 4
# Pfam	PF02815	MIR
# Pfam	PF06459	RR_TM4-6
# Pfam	PF08454	RIH_assoc
# Pfam	PF08709	Ins145_P3_rec
# Pfam	PF13833	EF-hand_8
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# Reactome	R-HSA-5578775	Ion homeostasis
# RecName	RYR2_HUMAN	Ryanodine receptor 2
# RefSeq	NP_001026	NM_001035.2. [Q92736-1]
# RefSeq	XP_006711868	XM_006711805.3. [Q92736-2]
# SEQUENCE CAUTION	RYR2_HUMAN	Sequence=CAH71369.1; Type=Miscellaneous discrepancy; Note=Erroneous gene model prediction.; Evidence={ECO 0000305}; Sequence=CAH71393.1; Type=Miscellaneous discrepancy; Note=Erroneous gene model prediction.; Evidence={ECO 0000305}; Sequence=CAH73918.1; Type=Miscellaneous discrepancy; Note=Erroneous gene model prediction.; Evidence={ECO 0000305}; Sequence=CAI14440.1; Type=Miscellaneous discrepancy; Note=Erroneous gene model prediction.; Evidence={ECO 0000305}; Sequence=CAI15350.1; Type=Miscellaneous discrepancy; Note=Erroneous gene model prediction.; Evidence={ECO 0000305}; Sequence=CAI15936.1; Type=Miscellaneous discrepancy; Note=Erroneous gene model prediction.; Evidence={ECO 0000305}; Sequence=CAI22065.1; Type=Miscellaneous discrepancy; Note=Erroneous gene model prediction.; Evidence={ECO 0000305}; 
# SIMILARITY	Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR2 subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 3 B30.2/SPRY domains. {ECO:0000255|PROSITE- ProRule	PRU00548}. 
# SIMILARITY	Contains 5 MIR domains. {ECO:0000255|PROSITE- ProRule	PRU00131}. 
# SMART	SM00449	SPRY; 3
# SMART	SM00472	MIR; 4
# SUBCELLULAR LOCATION	RYR2_HUMAN	Sarcoplasmic reticulum membrane {ECO 0000269|PubMed 10830164}; Multi-pass membrane protein {ECO 0000269|PubMed 10830164}. Membrane {ECO 0000305|PubMed 10830164}; Multi-pass membrane protein {ECO 0000305|PubMed 10830164}. Sarcoplasmic reticulum {ECO 0000250|UniProtKB P30957}. Note=The number of predicted transmembrane domains varies between orthologs, but both N- terminus and C-terminus seem to be cytoplasmic. {ECO 0000250}. 
# SUBUNIT	RYR2_HUMAN	Homotetramer. Can also form heterotetramers with RYR1 and RYR3 (By similarity). Interacts with FKBP1A and FKBP1B; these interactions may stabilize the channel in its closed state and prevent Ca(2+) leaks. Interacts with CALM and S100A1; these interactions regulate channel activity. Identified in a complex composed of RYR2, FKBP1B, PKA catalytic subunit, PRKAR2A, AKAP6, and the protein phosphatases PP2A and PP1. Interacts directly with FKBP1B, PKA, PP1 and PP2A. Interacts with SEPN1 (By similarity). {ECO 0000250|UniProtKB P30957, ECO 0000269|PubMed 10830164, ECO 0000269|PubMed 18650434}. 
# SUPFAM	SSF100909	SSF100909; 2
# SUPFAM	SSF47473	SSF47473
# SUPFAM	SSF49899	SSF49899; 2
# SUPFAM	SSF82109	SSF82109; 2
# TCDB	1.A.3.1	the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family
# TISSUE SPECIFICITY	RYR2_HUMAN	Detected in heart muscle (at protein level). Heart muscle, brain (cerebellum and hippocampus) and placenta. {ECO 0000269|PubMed 10830164, ECO 0000269|PubMed 9607712}. 
# UCSC	uc001hyl	human. [Q92736-1]
# WEB RESOURCE	RYR2_HUMAN	Name=Wikipedia; Note=RYR2 entry; URL="http //en.wikipedia.org/wiki/RYR2";
# WEB RESOURCE	RYR2_HUMAN	Name=Wikipedia; Note=Ryanodine receptor entry; URL="https //en.wikipedia.org/wiki/Ryanodine_receptor"; 
# eggNOG	ENOG410YCNW	LUCA
# eggNOG	KOG2243	Eukaryota
BLAST	swissprot:RYR2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:RYR2_HUMAN
BioCyc	ZFISH:G66-32043-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32043-MONOMER
COXPRESdb	6262	http://coxpresdb.jp/data/gene/6262.shtml
CleanEx	HS_RYR2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_RYR2
DIP	DIP-38325N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-38325N
DOI	10.1016/S0092-8674(00)80847-8	http://dx.doi.org/10.1016/S0092-8674(00)80847-8
DOI	10.1016/S0306-4522(97)00612-X	http://dx.doi.org/10.1016/S0306-4522(97)00612-X
DOI	10.1016/S0735-1097(02)01946-0	http://dx.doi.org/10.1016/S0735-1097(02)01946-0
DOI	10.1016/j.ijcard.2014.11.119	http://dx.doi.org/10.1016/j.ijcard.2014.11.119
DOI	10.1038/415198a	http://dx.doi.org/10.1038/415198a
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/sj.ejhg.5201061	http://dx.doi.org/10.1038/sj.ejhg.5201061
DOI	10.1042/bj3180477	http://dx.doi.org/10.1042/bj3180477
DOI	10.1042/bj3220777	http://dx.doi.org/10.1042/bj3220777
DOI	10.1073/pnas.0706573104	http://dx.doi.org/10.1073/pnas.0706573104
DOI	10.1074/jbc.M804432200	http://dx.doi.org/10.1074/jbc.M804432200
DOI	10.1093/hmg/10.3.189	http://dx.doi.org/10.1093/hmg/10.3.189
DOI	10.1101/cshperspect.a003996	http://dx.doi.org/10.1101/cshperspect.a003996
DOI	10.1161/01.CIR.0000020013.73106.D8	http://dx.doi.org/10.1161/01.CIR.0000020013.73106.D8
DOI	10.1161/01.CIR.0000144471.98080.CA	http://dx.doi.org/10.1161/01.CIR.0000144471.98080.CA
DOI	10.1161/01.CIR.103.2.196	http://dx.doi.org/10.1161/01.CIR.103.2.196
DOI	10.1161/01.CIR.103.4.485	http://dx.doi.org/10.1161/01.CIR.103.4.485
DOI	10.1161/CIRCRESAHA.109.203836	http://dx.doi.org/10.1161/CIRCRESAHA.109.203836
DOI	10.1371/journal.pone.0139058	http://dx.doi.org/10.1371/journal.pone.0139058
DOI	10.2741/3591	http://dx.doi.org/10.2741/3591
DOI	10.3892/mmr_00000240	http://dx.doi.org/10.3892/mmr_00000240
DOI	10.4065/79.11.1380	http://dx.doi.org/10.4065/79.11.1380
EMBL	AJ002511	http://www.ebi.ac.uk/ena/data/view/AJ002511
EMBL	AJ300340	http://www.ebi.ac.uk/ena/data/view/AJ300340
EMBL	AJ300341	http://www.ebi.ac.uk/ena/data/view/AJ300341
EMBL	AJ300342	http://www.ebi.ac.uk/ena/data/view/AJ300342
EMBL	AJ300343	http://www.ebi.ac.uk/ena/data/view/AJ300343
EMBL	AJ300344	http://www.ebi.ac.uk/ena/data/view/AJ300344
EMBL	AJ300345	http://www.ebi.ac.uk/ena/data/view/AJ300345
EMBL	AJ300346	http://www.ebi.ac.uk/ena/data/view/AJ300346
EMBL	AJ300347	http://www.ebi.ac.uk/ena/data/view/AJ300347
EMBL	AJ300348	http://www.ebi.ac.uk/ena/data/view/AJ300348
EMBL	AJ300349	http://www.ebi.ac.uk/ena/data/view/AJ300349
EMBL	AJ300350	http://www.ebi.ac.uk/ena/data/view/AJ300350
EMBL	AJ300351	http://www.ebi.ac.uk/ena/data/view/AJ300351
EMBL	AJ300352	http://www.ebi.ac.uk/ena/data/view/AJ300352
EMBL	AJ300353	http://www.ebi.ac.uk/ena/data/view/AJ300353
EMBL	AJ300354	http://www.ebi.ac.uk/ena/data/view/AJ300354
EMBL	AJ300355	http://www.ebi.ac.uk/ena/data/view/AJ300355
EMBL	AJ300356	http://www.ebi.ac.uk/ena/data/view/AJ300356
EMBL	AJ300357	http://www.ebi.ac.uk/ena/data/view/AJ300357
EMBL	AJ300358	http://www.ebi.ac.uk/ena/data/view/AJ300358
EMBL	AJ300359	http://www.ebi.ac.uk/ena/data/view/AJ300359
EMBL	AJ300360	http://www.ebi.ac.uk/ena/data/view/AJ300360
EMBL	AJ300361	http://www.ebi.ac.uk/ena/data/view/AJ300361
EMBL	AJ300362	http://www.ebi.ac.uk/ena/data/view/AJ300362
EMBL	AJ300363	http://www.ebi.ac.uk/ena/data/view/AJ300363
EMBL	AJ300364	http://www.ebi.ac.uk/ena/data/view/AJ300364
EMBL	AJ300365	http://www.ebi.ac.uk/ena/data/view/AJ300365
EMBL	AJ300366	http://www.ebi.ac.uk/ena/data/view/AJ300366
EMBL	AJ300367	http://www.ebi.ac.uk/ena/data/view/AJ300367
EMBL	AJ300368	http://www.ebi.ac.uk/ena/data/view/AJ300368
EMBL	AJ300369	http://www.ebi.ac.uk/ena/data/view/AJ300369
EMBL	AJ300370	http://www.ebi.ac.uk/ena/data/view/AJ300370
EMBL	AJ300371	http://www.ebi.ac.uk/ena/data/view/AJ300371
EMBL	AJ300372	http://www.ebi.ac.uk/ena/data/view/AJ300372
EMBL	AJ300373	http://www.ebi.ac.uk/ena/data/view/AJ300373
EMBL	AJ300374	http://www.ebi.ac.uk/ena/data/view/AJ300374
EMBL	AJ300375	http://www.ebi.ac.uk/ena/data/view/AJ300375
EMBL	AJ300376	http://www.ebi.ac.uk/ena/data/view/AJ300376
EMBL	AJ300377	http://www.ebi.ac.uk/ena/data/view/AJ300377
EMBL	AJ300378	http://www.ebi.ac.uk/ena/data/view/AJ300378
EMBL	AJ300379	http://www.ebi.ac.uk/ena/data/view/AJ300379
EMBL	AJ300380	http://www.ebi.ac.uk/ena/data/view/AJ300380
EMBL	AJ300381	http://www.ebi.ac.uk/ena/data/view/AJ300381
EMBL	AJ300382	http://www.ebi.ac.uk/ena/data/view/AJ300382
EMBL	AJ300383	http://www.ebi.ac.uk/ena/data/view/AJ300383
EMBL	AJ300384	http://www.ebi.ac.uk/ena/data/view/AJ300384
EMBL	AJ300385	http://www.ebi.ac.uk/ena/data/view/AJ300385
EMBL	AJ300386	http://www.ebi.ac.uk/ena/data/view/AJ300386
EMBL	AJ300387	http://www.ebi.ac.uk/ena/data/view/AJ300387
EMBL	AJ300388	http://www.ebi.ac.uk/ena/data/view/AJ300388
EMBL	AJ300389	http://www.ebi.ac.uk/ena/data/view/AJ300389
EMBL	AJ300390	http://www.ebi.ac.uk/ena/data/view/AJ300390
EMBL	AJ300391	http://www.ebi.ac.uk/ena/data/view/AJ300391
EMBL	AJ300392	http://www.ebi.ac.uk/ena/data/view/AJ300392
EMBL	AJ300393	http://www.ebi.ac.uk/ena/data/view/AJ300393
EMBL	AJ300394	http://www.ebi.ac.uk/ena/data/view/AJ300394
EMBL	AJ300395	http://www.ebi.ac.uk/ena/data/view/AJ300395
EMBL	AJ300396	http://www.ebi.ac.uk/ena/data/view/AJ300396
EMBL	AJ300397	http://www.ebi.ac.uk/ena/data/view/AJ300397
EMBL	AJ300398	http://www.ebi.ac.uk/ena/data/view/AJ300398
EMBL	AJ300399	http://www.ebi.ac.uk/ena/data/view/AJ300399
EMBL	AJ300400	http://www.ebi.ac.uk/ena/data/view/AJ300400
EMBL	AJ300401	http://www.ebi.ac.uk/ena/data/view/AJ300401
EMBL	AJ300402	http://www.ebi.ac.uk/ena/data/view/AJ300402
EMBL	AJ300403	http://www.ebi.ac.uk/ena/data/view/AJ300403
EMBL	AJ300404	http://www.ebi.ac.uk/ena/data/view/AJ300404
EMBL	AJ300405	http://www.ebi.ac.uk/ena/data/view/AJ300405
EMBL	AJ300406	http://www.ebi.ac.uk/ena/data/view/AJ300406
EMBL	AJ300407	http://www.ebi.ac.uk/ena/data/view/AJ300407
EMBL	AJ300408	http://www.ebi.ac.uk/ena/data/view/AJ300408
EMBL	AJ300409	http://www.ebi.ac.uk/ena/data/view/AJ300409
EMBL	AJ300410	http://www.ebi.ac.uk/ena/data/view/AJ300410
EMBL	AJ300411	http://www.ebi.ac.uk/ena/data/view/AJ300411
EMBL	AJ300412	http://www.ebi.ac.uk/ena/data/view/AJ300412
EMBL	AJ300413	http://www.ebi.ac.uk/ena/data/view/AJ300413
EMBL	AJ300414	http://www.ebi.ac.uk/ena/data/view/AJ300414
EMBL	AJ300415	http://www.ebi.ac.uk/ena/data/view/AJ300415
EMBL	AJ300416	http://www.ebi.ac.uk/ena/data/view/AJ300416
EMBL	AJ300417	http://www.ebi.ac.uk/ena/data/view/AJ300417
EMBL	AJ300418	http://www.ebi.ac.uk/ena/data/view/AJ300418
EMBL	AJ300419	http://www.ebi.ac.uk/ena/data/view/AJ300419
EMBL	AJ300420	http://www.ebi.ac.uk/ena/data/view/AJ300420
EMBL	AJ300421	http://www.ebi.ac.uk/ena/data/view/AJ300421
EMBL	AJ300422	http://www.ebi.ac.uk/ena/data/view/AJ300422
EMBL	AJ300423	http://www.ebi.ac.uk/ena/data/view/AJ300423
EMBL	AJ300424	http://www.ebi.ac.uk/ena/data/view/AJ300424
EMBL	AJ300425	http://www.ebi.ac.uk/ena/data/view/AJ300425
EMBL	AJ300426	http://www.ebi.ac.uk/ena/data/view/AJ300426
EMBL	AJ300427	http://www.ebi.ac.uk/ena/data/view/AJ300427
EMBL	AJ300428	http://www.ebi.ac.uk/ena/data/view/AJ300428
EMBL	AJ300429	http://www.ebi.ac.uk/ena/data/view/AJ300429
EMBL	AJ300430	http://www.ebi.ac.uk/ena/data/view/AJ300430
EMBL	AJ300431	http://www.ebi.ac.uk/ena/data/view/AJ300431
EMBL	AJ300432	http://www.ebi.ac.uk/ena/data/view/AJ300432
EMBL	AJ300433	http://www.ebi.ac.uk/ena/data/view/AJ300433
EMBL	AJ300434	http://www.ebi.ac.uk/ena/data/view/AJ300434
EMBL	AJ300435	http://www.ebi.ac.uk/ena/data/view/AJ300435
EMBL	AJ300436	http://www.ebi.ac.uk/ena/data/view/AJ300436
EMBL	AJ300437	http://www.ebi.ac.uk/ena/data/view/AJ300437
EMBL	AJ300438	http://www.ebi.ac.uk/ena/data/view/AJ300438
EMBL	AJ300439	http://www.ebi.ac.uk/ena/data/view/AJ300439
EMBL	AJ300440	http://www.ebi.ac.uk/ena/data/view/AJ300440
EMBL	AJ300441	http://www.ebi.ac.uk/ena/data/view/AJ300441
EMBL	AJ300442	http://www.ebi.ac.uk/ena/data/view/AJ300442
EMBL	AJ300443	http://www.ebi.ac.uk/ena/data/view/AJ300443
EMBL	AJ300444	http://www.ebi.ac.uk/ena/data/view/AJ300444
EMBL	AL356773	http://www.ebi.ac.uk/ena/data/view/AL356773
EMBL	AL356773	http://www.ebi.ac.uk/ena/data/view/AL356773
EMBL	AL356773	http://www.ebi.ac.uk/ena/data/view/AL356773
EMBL	AL356773	http://www.ebi.ac.uk/ena/data/view/AL356773
EMBL	AL356773	http://www.ebi.ac.uk/ena/data/view/AL356773
EMBL	AL356773	http://www.ebi.ac.uk/ena/data/view/AL356773
EMBL	AL356773	http://www.ebi.ac.uk/ena/data/view/AL356773
EMBL	AL359924	http://www.ebi.ac.uk/ena/data/view/AL359924
EMBL	AL359924	http://www.ebi.ac.uk/ena/data/view/AL359924
EMBL	AL359924	http://www.ebi.ac.uk/ena/data/view/AL359924
EMBL	AL359924	http://www.ebi.ac.uk/ena/data/view/AL359924
EMBL	AL359924	http://www.ebi.ac.uk/ena/data/view/AL359924
EMBL	AL359924	http://www.ebi.ac.uk/ena/data/view/AL359924
EMBL	AL359924	http://www.ebi.ac.uk/ena/data/view/AL359924
EMBL	AL365332	http://www.ebi.ac.uk/ena/data/view/AL365332
EMBL	AL365332	http://www.ebi.ac.uk/ena/data/view/AL365332
EMBL	AL365332	http://www.ebi.ac.uk/ena/data/view/AL365332
EMBL	AL365332	http://www.ebi.ac.uk/ena/data/view/AL365332
EMBL	AL365332	http://www.ebi.ac.uk/ena/data/view/AL365332
EMBL	AL365332	http://www.ebi.ac.uk/ena/data/view/AL365332
EMBL	AL365332	http://www.ebi.ac.uk/ena/data/view/AL365332
EMBL	AL391809	http://www.ebi.ac.uk/ena/data/view/AL391809
EMBL	AL391809	http://www.ebi.ac.uk/ena/data/view/AL391809
EMBL	AL391809	http://www.ebi.ac.uk/ena/data/view/AL391809
EMBL	AL391809	http://www.ebi.ac.uk/ena/data/view/AL391809
EMBL	AL391809	http://www.ebi.ac.uk/ena/data/view/AL391809
EMBL	AL391809	http://www.ebi.ac.uk/ena/data/view/AL391809
EMBL	AL391809	http://www.ebi.ac.uk/ena/data/view/AL391809
EMBL	AL442065	http://www.ebi.ac.uk/ena/data/view/AL442065
EMBL	AL442065	http://www.ebi.ac.uk/ena/data/view/AL442065
EMBL	AL442065	http://www.ebi.ac.uk/ena/data/view/AL442065
EMBL	AL442065	http://www.ebi.ac.uk/ena/data/view/AL442065
EMBL	AL442065	http://www.ebi.ac.uk/ena/data/view/AL442065
EMBL	AL442065	http://www.ebi.ac.uk/ena/data/view/AL442065
EMBL	AL442065	http://www.ebi.ac.uk/ena/data/view/AL442065
EMBL	AL445473	http://www.ebi.ac.uk/ena/data/view/AL445473
EMBL	AL445473	http://www.ebi.ac.uk/ena/data/view/AL445473
EMBL	AL445473	http://www.ebi.ac.uk/ena/data/view/AL445473
EMBL	AL445473	http://www.ebi.ac.uk/ena/data/view/AL445473
EMBL	AL445473	http://www.ebi.ac.uk/ena/data/view/AL445473
EMBL	AL445473	http://www.ebi.ac.uk/ena/data/view/AL445473
EMBL	AL445473	http://www.ebi.ac.uk/ena/data/view/AL445473
EMBL	AL513130	http://www.ebi.ac.uk/ena/data/view/AL513130
EMBL	AL513130	http://www.ebi.ac.uk/ena/data/view/AL513130
EMBL	AL513130	http://www.ebi.ac.uk/ena/data/view/AL513130
EMBL	AL513130	http://www.ebi.ac.uk/ena/data/view/AL513130
EMBL	AL513130	http://www.ebi.ac.uk/ena/data/view/AL513130
EMBL	AL513130	http://www.ebi.ac.uk/ena/data/view/AL513130
EMBL	AL513130	http://www.ebi.ac.uk/ena/data/view/AL513130
EMBL	X91869	http://www.ebi.ac.uk/ena/data/view/X91869
EMBL	X98330	http://www.ebi.ac.uk/ena/data/view/X98330
EMBL	Y08218	http://www.ebi.ac.uk/ena/data/view/Y08218
Ensembl	ENST00000366574	http://www.ensembl.org/id/ENST00000366574
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005790
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0014701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014701
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016529	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016529
GO_component	GO:0030018	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030018
GO_component	GO:0033017	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033017
GO_component	GO:0034704	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034704
GO_component	GO:0042383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042383
GO_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005219
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0005516	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005516
GO_function	GO:0015278	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015278
GO_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GO_function	GO:0034236	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034236
GO_function	GO:0034237	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034237
GO_function	GO:0042802	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802
GO_function	GO:0043924	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043924
GO_function	GO:0044325	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044325
GO_function	GO:0048763	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048763
GO_process	GO:0001666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001666
GO_process	GO:0002027	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002027
GO_process	GO:0003143	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003143
GO_process	GO:0003220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003220
GO_process	GO:0003300	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003300
GO_process	GO:0005513	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005513
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0006874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874
GO_process	GO:0010460	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010460
GO_process	GO:0010881	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010881
GO_process	GO:0010882	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010882
GO_process	GO:0014808	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014808
GO_process	GO:0014850	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014850
GO_process	GO:0019722	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019722
GO_process	GO:0030509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030509
GO_process	GO:0031000	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031000
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0035584	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035584
GO_process	GO:0035994	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035994
GO_process	GO:0051209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051209
GO_process	GO:0051284	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051284
GO_process	GO:0051480	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051480
GO_process	GO:0051775	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051775
GO_process	GO:0055117	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055117
GO_process	GO:0060048	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060048
GO_process	GO:0060070	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060070
GO_process	GO:0060402	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060402
GO_process	GO:0070296	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070296
GO_process	GO:0071313	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071313
GO_process	GO:0071872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071872
GO_process	GO:0072599	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072599
GO_process	GO:0086005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086005
GO_process	GO:0086029	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086029
GO_process	GO:0086064	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086064
GO_process	GO:0097050	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097050
GO_process	GO:0098735	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098735
GO_process	GO:0098904	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098904
GO_process	GO:0098907	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098907
GO_process	GO:0098910	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098910
GO_process	GO:0098911	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098911
GO_process	GO:1901896	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901896
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0008219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.10.238.10	http://www.cathdb.info/version/latest/superfamily/1.10.238.10
Gene3D	1.25.10.30	http://www.cathdb.info/version/latest/superfamily/1.25.10.30
GeneCards	RYR2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=RYR2
GeneID	6262	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6262
GeneTree	ENSGT00760000119152	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119152
HGNC	HGNC:10484	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10484
HOGENOM	HOG000231428	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231428&db=HOGENOM6
HOVERGEN	HBG006699	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006699&db=HOVERGEN
HPA	HPA020028	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA020028
InParanoid	Q92736	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q92736
IntAct	Q92736	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q92736*
InterPro	IPR000699	http://www.ebi.ac.uk/interpro/entry/IPR000699
InterPro	IPR001870	http://www.ebi.ac.uk/interpro/entry/IPR001870
InterPro	IPR002048	http://www.ebi.ac.uk/interpro/entry/IPR002048
InterPro	IPR003032	http://www.ebi.ac.uk/interpro/entry/IPR003032
InterPro	IPR003877	http://www.ebi.ac.uk/interpro/entry/IPR003877
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR009460	http://www.ebi.ac.uk/interpro/entry/IPR009460
InterPro	IPR011992	http://www.ebi.ac.uk/interpro/entry/IPR011992
InterPro	IPR013320	http://www.ebi.ac.uk/interpro/entry/IPR013320
InterPro	IPR013333	http://www.ebi.ac.uk/interpro/entry/IPR013333
InterPro	IPR013662	http://www.ebi.ac.uk/interpro/entry/IPR013662
InterPro	IPR014821	http://www.ebi.ac.uk/interpro/entry/IPR014821
InterPro	IPR015925	http://www.ebi.ac.uk/interpro/entry/IPR015925
InterPro	IPR016093	http://www.ebi.ac.uk/interpro/entry/IPR016093
Jabion	6262	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6262
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00293	http://www.genome.jp/dbget-bin/www_bget?H00293
KEGG_Disease	H01019	http://www.genome.jp/dbget-bin/www_bget?H01019
KEGG_Gene	hsa:6262	http://www.genome.jp/dbget-bin/www_bget?hsa:6262
KEGG_Orthology	KO:K04962	http://www.genome.jp/dbget-bin/www_bget?KO:K04962
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko04713	http://www.genome.jp/kegg-bin/show_pathway?ko04713
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
KEGG_Pathway	ko05410	http://www.genome.jp/kegg-bin/show_pathway?ko05410
KEGG_Pathway	ko05412	http://www.genome.jp/kegg-bin/show_pathway?ko05412
KEGG_Pathway	ko05414	http://www.genome.jp/kegg-bin/show_pathway?ko05414
MIM	180902	http://www.ncbi.nlm.nih.gov/omim/180902
MIM	600996	http://www.ncbi.nlm.nih.gov/omim/600996
MIM	604772	http://www.ncbi.nlm.nih.gov/omim/604772
MINT	MINT-1201008	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1201008
OMA	RWWEHGP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RWWEHGP
Orphanet	293888	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=293888
Orphanet	293899	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=293899
Orphanet	293910	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=293910
Orphanet	3286	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=3286
OrthoDB	EOG091G00T0	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00T0
PANTHER	PTHR13715	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13715
PDB	4JKQ	http://www.ebi.ac.uk/pdbe-srv/view/entry/4JKQ
PDBsum	4JKQ	http://www.ebi.ac.uk/pdbsum/4JKQ
PRINTS	PR00795	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00795
PROSITE	PS50188	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50188
PROSITE	PS50919	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50919
PSORT	swissprot:RYR2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:RYR2_HUMAN
PSORT-B	swissprot:RYR2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:RYR2_HUMAN
PSORT2	swissprot:RYR2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:RYR2_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF00622	http://pfam.xfam.org/family/PF00622
Pfam	PF01365	http://pfam.xfam.org/family/PF01365
Pfam	PF02026	http://pfam.xfam.org/family/PF02026
Pfam	PF02815	http://pfam.xfam.org/family/PF02815
Pfam	PF06459	http://pfam.xfam.org/family/PF06459
Pfam	PF08454	http://pfam.xfam.org/family/PF08454
Pfam	PF08709	http://pfam.xfam.org/family/PF08709
Pfam	PF13833	http://pfam.xfam.org/family/PF13833
Phobius	swissprot:RYR2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:RYR2_HUMAN
PhylomeDB	Q92736	http://phylomedb.org/?seqid=Q92736
ProteinModelPortal	Q92736	http://www.proteinmodelportal.org/query/uniprot/Q92736
PubMed	10830164	http://www.ncbi.nlm.nih.gov/pubmed/10830164
PubMed	11157710	http://www.ncbi.nlm.nih.gov/pubmed/11157710
PubMed	11159936	http://www.ncbi.nlm.nih.gov/pubmed/11159936
PubMed	11208676	http://www.ncbi.nlm.nih.gov/pubmed/11208676
PubMed	11805843	http://www.ncbi.nlm.nih.gov/pubmed/11805843
PubMed	12093772	http://www.ncbi.nlm.nih.gov/pubmed/12093772
PubMed	12106942	http://www.ncbi.nlm.nih.gov/pubmed/12106942
PubMed	14571276	http://www.ncbi.nlm.nih.gov/pubmed/14571276
PubMed	15046072	http://www.ncbi.nlm.nih.gov/pubmed/15046072
PubMed	15046073	http://www.ncbi.nlm.nih.gov/pubmed/15046073
PubMed	15466642	http://www.ncbi.nlm.nih.gov/pubmed/15466642
PubMed	15544015	http://www.ncbi.nlm.nih.gov/pubmed/15544015
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17984046	http://www.ncbi.nlm.nih.gov/pubmed/17984046
PubMed	18650434	http://www.ncbi.nlm.nih.gov/pubmed/18650434
PubMed	19482609	http://www.ncbi.nlm.nih.gov/pubmed/19482609
PubMed	20056922	http://www.ncbi.nlm.nih.gov/pubmed/20056922
PubMed	20961976	http://www.ncbi.nlm.nih.gov/pubmed/20961976
PubMed	21472222	http://www.ncbi.nlm.nih.gov/pubmed/21472222
PubMed	25463374	http://www.ncbi.nlm.nih.gov/pubmed/25463374
PubMed	26405799	http://www.ncbi.nlm.nih.gov/pubmed/26405799
PubMed	8809036	http://www.ncbi.nlm.nih.gov/pubmed/8809036
PubMed	9148749	http://www.ncbi.nlm.nih.gov/pubmed/9148749
PubMed	9607712	http://www.ncbi.nlm.nih.gov/pubmed/9607712
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
RefSeq	NP_001026	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001026
RefSeq	XP_006711868	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006711868
SMART	SM00449	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00449
SMART	SM00472	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00472
SMR	Q92736	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q92736
STRING	9606.ENSP00000355533	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000355533&targetmode=cogs
SUPFAM	SSF100909	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF100909
SUPFAM	SSF47473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47473
SUPFAM	SSF49899	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49899
SUPFAM	SSF82109	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82109
TCDB	1.A.3.1	http://www.tcdb.org/search/result.php?tc=1.A.3.1
UCSC	uc001hyl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001hyl&org=rat
UniGene	Hs.109514	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.109514
UniGene	Hs.738571	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.738571
UniProtKB	RYR2_HUMAN	http://www.uniprot.org/uniprot/RYR2_HUMAN
UniProtKB-AC	Q92736	http://www.uniprot.org/uniprot/Q92736
charge	swissprot:RYR2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:RYR2_HUMAN
eggNOG	ENOG410YCNW	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YCNW
eggNOG	KOG2243	http://eggnogapi.embl.de/nog_data/html/tree/KOG2243
epestfind	swissprot:RYR2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:RYR2_HUMAN
garnier	swissprot:RYR2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:RYR2_HUMAN
helixturnhelix	swissprot:RYR2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:RYR2_HUMAN
hmoment	swissprot:RYR2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:RYR2_HUMAN
iep	swissprot:RYR2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:RYR2_HUMAN
inforesidue	swissprot:RYR2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:RYR2_HUMAN
neXtProt	NX_Q92736	http://www.nextprot.org/db/entry/NX_Q92736
octanol	swissprot:RYR2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:RYR2_HUMAN
pepcoil	swissprot:RYR2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:RYR2_HUMAN
pepdigest	swissprot:RYR2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:RYR2_HUMAN
pepinfo	swissprot:RYR2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:RYR2_HUMAN
pepnet	swissprot:RYR2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:RYR2_HUMAN
pepstats	swissprot:RYR2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:RYR2_HUMAN
pepwheel	swissprot:RYR2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:RYR2_HUMAN
pepwindow	swissprot:RYR2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:RYR2_HUMAN
sigcleave	swissprot:RYR2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:RYR2_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNKC_HUMAN	Tandem pore domain halothane-inhibited potassium channel 2
# Ensembl	ENST00000327876	ENSP00000327611; ENSG00000184261
# FUNCTION	KCNKC_HUMAN	Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel (By similarity). {ECO 0000250}. 
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0005244	voltage-gated ion channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0022841	potassium ion leak channel activity; IBA:GO_Central.
# GO_process	GO:0030322	stabilization of membrane potential; IBA:GO_Central.
# GO_process	GO:0071805	potassium ion transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9HB15	HS
# HGNC	HGNC:6274	KCNK12
# InterPro	IPR003280	2pore_dom_K_chnl
# InterPro	IPR005410	2pore_dom_K_chnl_THIK
# InterPro	IPR013099	K_chnl_dom
# KEGG_Brite	ko04040	Ion channels
# MIM	607366	gene
# Organism	KCNKC_HUMAN	Homo sapiens (Human)
# PRINTS	PR01333	2POREKCHANEL
# PRINTS	PR01588	THIKCHANNEL
# Pfam	PF07885	Ion_trans_2; 2
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-5576886	Phase 4 - resting membrane potential
# RecName	KCNKC_HUMAN	Potassium channel subfamily K member 12
# RefSeq	NP_071338	NM_022055.1
# SIMILARITY	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCNKC_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUBUNIT	Heterodimer. {ECO	0000305}. 
# UCSC	uc002rwb	human
# eggNOG	ENOG410XRZJ	LUCA
# eggNOG	KOG4404	Eukaryota
BLAST	swissprot:KCNKC_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNKC_HUMAN
BioCyc	ZFISH:G66-31450-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31450-MONOMER
COXPRESdb	56660	http://coxpresdb.jp/data/gene/56660.shtml
CleanEx	HS_KCNK12	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNK12
DOI	10.1074/jbc.M008985200	http://dx.doi.org/10.1074/jbc.M008985200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF287302	http://www.ebi.ac.uk/ena/data/view/AF287302
EMBL	BC047749	http://www.ebi.ac.uk/ena/data/view/BC047749
Ensembl	ENST00000327876	http://www.ensembl.org/id/ENST00000327876
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005244
GO_function	GO:0022841	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022841
GO_process	GO:0030322	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030322
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	KCNK12	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNK12
GeneID	56660	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56660
GeneTree	ENSGT00860000133807	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00860000133807
HGNC	HGNC:6274	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6274
HOGENOM	HOG000013227	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000013227&db=HOGENOM6
HOVERGEN	HBG052238	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052238&db=HOVERGEN
HPA	CAB025604	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB025604
InParanoid	Q9HB15	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9HB15
IntAct	Q9HB15	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9HB15*
InterPro	IPR003280	http://www.ebi.ac.uk/interpro/entry/IPR003280
InterPro	IPR005410	http://www.ebi.ac.uk/interpro/entry/IPR005410
InterPro	IPR013099	http://www.ebi.ac.uk/interpro/entry/IPR013099
Jabion	56660	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=56660
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:56660	http://www.genome.jp/dbget-bin/www_bget?hsa:56660
KEGG_Orthology	KO:K04921	http://www.genome.jp/dbget-bin/www_bget?KO:K04921
MIM	607366	http://www.ncbi.nlm.nih.gov/omim/607366
OMA	MISMRDL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MISMRDL
OrthoDB	EOG091G06SB	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G06SB
PRINTS	PR01333	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01333
PRINTS	PR01588	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01588
PSORT	swissprot:KCNKC_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNKC_HUMAN
PSORT-B	swissprot:KCNKC_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNKC_HUMAN
PSORT2	swissprot:KCNKC_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNKC_HUMAN
Pfam	PF07885	http://pfam.xfam.org/family/PF07885
PharmGKB	PA30054	http://www.pharmgkb.org/do/serve?objId=PA30054&objCls=Gene
Phobius	swissprot:KCNKC_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNKC_HUMAN
PhylomeDB	Q9HB15	http://phylomedb.org/?seqid=Q9HB15
ProteinModelPortal	Q9HB15	http://www.proteinmodelportal.org/query/uniprot/Q9HB15
PubMed	11060316	http://www.ncbi.nlm.nih.gov/pubmed/11060316
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-5576886	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576886
RefSeq	NP_071338	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_071338
STRING	9606.ENSP00000327611	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000327611&targetmode=cogs
UCSC	uc002rwb	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002rwb&org=rat
UniGene	Hs.591586	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.591586
UniProtKB	KCNKC_HUMAN	http://www.uniprot.org/uniprot/KCNKC_HUMAN
UniProtKB-AC	Q9HB15	http://www.uniprot.org/uniprot/Q9HB15
charge	swissprot:KCNKC_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNKC_HUMAN
eggNOG	ENOG410XRZJ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRZJ
eggNOG	KOG4404	http://eggnogapi.embl.de/nog_data/html/tree/KOG4404
epestfind	swissprot:KCNKC_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNKC_HUMAN
garnier	swissprot:KCNKC_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNKC_HUMAN
helixturnhelix	swissprot:KCNKC_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNKC_HUMAN
hmoment	swissprot:KCNKC_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNKC_HUMAN
iep	swissprot:KCNKC_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNKC_HUMAN
inforesidue	swissprot:KCNKC_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNKC_HUMAN
neXtProt	NX_Q9HB15	http://www.nextprot.org/db/entry/NX_Q9HB15
octanol	swissprot:KCNKC_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNKC_HUMAN
pepcoil	swissprot:KCNKC_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNKC_HUMAN
pepdigest	swissprot:KCNKC_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNKC_HUMAN
pepinfo	swissprot:KCNKC_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNKC_HUMAN
pepnet	swissprot:KCNKC_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNKC_HUMAN
pepstats	swissprot:KCNKC_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNKC_HUMAN
pepwheel	swissprot:KCNKC_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNKC_HUMAN
pepwindow	swissprot:KCNKC_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNKC_HUMAN
sigcleave	swissprot:KCNKC_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNKC_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AP1S2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P56377-1; Sequence=Displayed; Name=2; IsoId=P56377-2; Sequence=VSP_053671, VSP_053672; Note=No experimental confirmation available.; 
# AltName	AP1S2_HUMAN	Adaptor protein complex AP-1 subunit sigma-1B
# AltName	AP1S2_HUMAN	Adaptor-related protein complex 1 subunit sigma-1B
# AltName	AP1S2_HUMAN	Clathrin assembly protein complex 1 sigma-1B small chain
# AltName	AP1S2_HUMAN	Golgi adaptor HA1/AP1 adaptin sigma-1B subunit
# AltName	AP1S2_HUMAN	Sigma 1B subunit of AP-1 clathrin
# AltName	AP1S2_HUMAN	Sigma-adaptin 1B
# AltName	AP1S2_HUMAN	Sigma1B-adaptin
# BioGrid	114419	36
# CCDS	CCDS14173	-. [P56377-1]
# ChiTaRS	AP1S2	human
# DISEASE	AP1S2_HUMAN	Pettigrew syndrome (PGS) [MIM 304340]  A syndrome characterized by mental retardation and additional highly variable features, including choreoathetosis, hydrocephalus, Dandy-Walker malformation, seizures, and iron or calcium deposition in the brain. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO 0000269|PubMed 17186471}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000329235	ENSP00000328789; ENSG00000182287. [P56377-1]
# ExpressionAtlas	P56377	baseline and differential
# FUNCTION	AP1S2_HUMAN	Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. 
# GO_component	GO:0000139	Golgi membrane; TAS:Reactome.
# GO_component	GO:0005765	lysosomal membrane; TAS:Reactome.
# GO_component	GO:0005794	Golgi apparatus; IDA:HPA.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0005905	clathrin-coated pit; IEA:UniProtKB-SubCell.
# GO_component	GO:0030119	AP-type membrane coat adaptor complex; TAS:ProtInc.
# GO_component	GO:0030659	cytoplasmic vesicle membrane; TAS:Reactome.
# GO_component	GO:0030669	clathrin-coated endocytic vesicle membrane; TAS:Reactome.
# GO_component	GO:0032588	trans-Golgi network membrane; TAS:Reactome.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_function	GO:0008565	protein transporter activity; IEA:InterPro.
# GO_process	GO:0006886	intracellular protein transport; IEA:InterPro.
# GO_process	GO:0016192	vesicle-mediated transport; IEA:InterPro.
# GO_process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
# GO_process	GO:0050690	regulation of defense response to virus by virus; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# Genevisible	P56377	HS
# HGNC	HGNC:560	AP1S2
# INTERACTION	AP1S2_HUMAN	O43747-2 AP1G1; NbExp=5; IntAct=EBI-1054374, EBI-10185819; 
# IntAct	P56377	24
# InterPro	IPR000804	Clathrin_sm-chain_CS
# InterPro	IPR011012	Longin-like_dom
# InterPro	IPR016635	AP_complex_ssu
# InterPro	IPR022775	AP_mu_sigma_su
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Pathway	ko04142	Lysosome
# MIM	300629	gene
# MIM	304340	phenotype
# Organism	AP1S2_HUMAN	Homo sapiens (Human)
# Orphanet	1568	X-linked intellectual disability - Dandy-Walker malformation - basal ganglia disease - Seizures
# Orphanet	85335	Fried syndrome
# PANTHER	PTHR11753	PTHR11753
# PIRSF	PIRSF015588	AP_complex_sigma
# PROSITE	PS00989	CLAT_ADAPTOR_S
# Pfam	PF01217	Clat_adaptor_s
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-164940	Nef mediated downregulation of MHC class I complex cell surface expression
# Reactome	R-HSA-2132295	MHC class II antigen presentation
# Reactome	R-HSA-432720	Lysosome Vesicle Biogenesis
# Reactome	R-HSA-432722	Golgi Associated Vesicle Biogenesis
# RecName	AP1S2_HUMAN	AP-1 complex subunit sigma-2
# RefSeq	NP_003907	NM_003916.4. [P56377-1]
# RefSeq	XP_011543901	XM_011545599.1. [P56377-2]
# RefSeq	XP_016885414	XM_017029925.1. [P56377-2]
# SEQUENCE CAUTION	Sequence=AAG44595.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the adaptor complexes small subunit family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	AP1S2_HUMAN	Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. 
# SUBUNIT	AP1S2_HUMAN	Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta- type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). Binds to MUC1. 
# SUPFAM	SSF64356	SSF64356
# TISSUE SPECIFICITY	AP1S2_HUMAN	Widely expressed. 
# eggNOG	COG5030	LUCA
# eggNOG	KOG0934	Eukaryota
BLAST	swissprot:AP1S2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AP1S2_HUMAN
BioCyc	ZFISH:ENSG00000128989-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000128989-MONOMER
COXPRESdb	8905	http://coxpresdb.jp/data/gene/8905.shtml
CleanEx	HS_AP1S2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AP1S2
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.273.38.24693	http://dx.doi.org/10.1074/jbc.273.38.24693
DOI	10.1074/jbc.M409360200	http://dx.doi.org/10.1074/jbc.M409360200
DOI	10.1086/510137	http://dx.doi.org/10.1086/510137
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AB015320	http://www.ebi.ac.uk/ena/data/view/AB015320
EMBL	AC004106	http://www.ebi.ac.uk/ena/data/view/AC004106
EMBL	AF091077	http://www.ebi.ac.uk/ena/data/view/AF091077
EMBL	AF251295	http://www.ebi.ac.uk/ena/data/view/AF251295
EMBL	AK299921	http://www.ebi.ac.uk/ena/data/view/AK299921
EMBL	BC001117	http://www.ebi.ac.uk/ena/data/view/BC001117
EMBL	BC071867	http://www.ebi.ac.uk/ena/data/view/BC071867
EMBL	BT006738	http://www.ebi.ac.uk/ena/data/view/BT006738
Ensembl	ENST00000329235	http://www.ensembl.org/id/ENST00000329235
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005905	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005905
GO_component	GO:0030119	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030119
GO_component	GO:0030659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030659
GO_component	GO:0030669	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030669
GO_component	GO:0032588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032588
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0006886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006886
GO_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GO_process	GO:0019886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019886
GO_process	GO:0050690	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050690
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GeneCards	AP1S2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=AP1S2
GeneID	8905	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8905
GeneTree	ENSGT00530000062839	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062839
HGNC	HGNC:560	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:560
HOGENOM	HOG000185227	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000185227&db=HOGENOM6
HOVERGEN	HBG050517	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050517&db=HOVERGEN
HPA	HPA049894	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA049894
HPA	HPA060945	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA060945
InParanoid	P56377	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P56377
IntAct	P56377	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P56377*
InterPro	IPR000804	http://www.ebi.ac.uk/interpro/entry/IPR000804
InterPro	IPR011012	http://www.ebi.ac.uk/interpro/entry/IPR011012
InterPro	IPR016635	http://www.ebi.ac.uk/interpro/entry/IPR016635
InterPro	IPR022775	http://www.ebi.ac.uk/interpro/entry/IPR022775
Jabion	8905	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=8905
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Gene	hsa:8905	http://www.genome.jp/dbget-bin/www_bget?hsa:8905
KEGG_Orthology	KO:K12394	http://www.genome.jp/dbget-bin/www_bget?KO:K12394
KEGG_Pathway	ko04142	http://www.genome.jp/kegg-bin/show_pathway?ko04142
MIM	300629	http://www.ncbi.nlm.nih.gov/omim/300629
MIM	304340	http://www.ncbi.nlm.nih.gov/omim/304340
MINT	MINT-3021368	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3021368
Orphanet	1568	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1568
Orphanet	85335	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=85335
PANTHER	PTHR11753	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11753
PROSITE	PS00989	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00989
PSORT	swissprot:AP1S2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AP1S2_HUMAN
PSORT-B	swissprot:AP1S2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AP1S2_HUMAN
PSORT2	swissprot:AP1S2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AP1S2_HUMAN
Pfam	PF01217	http://pfam.xfam.org/family/PF01217
PharmGKB	PA24851	http://www.pharmgkb.org/do/serve?objId=PA24851&objCls=Gene
Phobius	swissprot:AP1S2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AP1S2_HUMAN
PhylomeDB	P56377	http://phylomedb.org/?seqid=P56377
ProteinModelPortal	P56377	http://www.proteinmodelportal.org/query/uniprot/P56377
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15471854	http://www.ncbi.nlm.nih.gov/pubmed/15471854
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	17186471	http://www.ncbi.nlm.nih.gov/pubmed/17186471
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	9733768	http://www.ncbi.nlm.nih.gov/pubmed/9733768
Reactome	R-HSA-164940	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-164940
Reactome	R-HSA-2132295	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2132295
Reactome	R-HSA-432720	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432720
Reactome	R-HSA-432722	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432722
RefSeq	NP_003907	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003907
RefSeq	XP_011543901	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011543901
RefSeq	XP_016885414	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016885414
SMR	P56377	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P56377
STRING	9606.ENSP00000328789	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000328789&targetmode=cogs
SUPFAM	SSF64356	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF64356
UniGene	Hs.121592	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.121592
UniProtKB	AP1S2_HUMAN	http://www.uniprot.org/uniprot/AP1S2_HUMAN
UniProtKB-AC	P56377	http://www.uniprot.org/uniprot/P56377
charge	swissprot:AP1S2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AP1S2_HUMAN
eggNOG	COG5030	http://eggnogapi.embl.de/nog_data/html/tree/COG5030
eggNOG	KOG0934	http://eggnogapi.embl.de/nog_data/html/tree/KOG0934
epestfind	swissprot:AP1S2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AP1S2_HUMAN
garnier	swissprot:AP1S2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AP1S2_HUMAN
helixturnhelix	swissprot:AP1S2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AP1S2_HUMAN
hmoment	swissprot:AP1S2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AP1S2_HUMAN
iep	swissprot:AP1S2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AP1S2_HUMAN
inforesidue	swissprot:AP1S2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AP1S2_HUMAN
neXtProt	NX_P56377	http://www.nextprot.org/db/entry/NX_P56377
octanol	swissprot:AP1S2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AP1S2_HUMAN
pepcoil	swissprot:AP1S2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AP1S2_HUMAN
pepdigest	swissprot:AP1S2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AP1S2_HUMAN
pepinfo	swissprot:AP1S2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AP1S2_HUMAN
pepnet	swissprot:AP1S2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AP1S2_HUMAN
pepstats	swissprot:AP1S2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AP1S2_HUMAN
pepwheel	swissprot:AP1S2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AP1S2_HUMAN
pepwindow	swissprot:AP1S2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AP1S2_HUMAN
sigcleave	swissprot:AP1S2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AP1S2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNQ1_HUMAN	Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=1; IsoId=P51787-1; Sequence=Displayed; Name=2; Synonyms=TKvLQT1; IsoId=P51787-2; Sequence=VSP_000981, VSP_000982; 
# AltName	IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1 {ECO:0000305|PubMed	9312006}
# AltName	KQT-like 1 {ECO	0000305}
# AltName	Voltage-gated potassium channel subunit Kv7.1 {ECO:0000305|PubMed	20533308}
# BioGrid	109985	15
# CCDS	CCDS7736	-. [P51787-1]
# ChiTaRS	KCNQ1	human
# DISEASE	KCNQ1_HUMAN	Atrial fibrillation, familial, 3 (ATFB3) [MIM 607554]  An autosomal dominant form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. {ECO 0000269|PubMed 12522251}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	KCNQ1_HUMAN	Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM 125853]  A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO 0000269|PubMed 18711366, ECO 0000269|PubMed 18711367, ECO 0000269|PubMed 24390345}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# DISEASE	KCNQ1_HUMAN	Jervell and Lange-Nielsen syndrome 1 (JLNS1) [MIM 220400]  An autosomal recessive disorder characterized by congenital deafness, prolongation of the QT interval, syncopal attacks due to ventricular arrhythmias, and a high risk of sudden death. {ECO 0000269|PubMed 10090886, ECO 0000269|PubMed 10728423, ECO 0000269|PubMed 18400097, ECO 0000269|PubMed 18441444, ECO 0000269|PubMed 25705178, ECO 0000269|PubMed 9781056}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	KCNQ1_HUMAN	Long QT syndrome 1 (LQT1) [MIM 192500]  A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. {ECO 0000269|PubMed 10024302, ECO 0000269|PubMed 10220144, ECO 0000269|PubMed 10220146, ECO 0000269|PubMed 10367071, ECO 0000269|PubMed 10409658, ECO 0000269|PubMed 10482963, ECO 0000269|PubMed 10728423, ECO 0000269|PubMed 10973849, ECO 0000269|PubMed 11799244, ECO 0000269|PubMed 12442276, ECO 0000269|PubMed 15840476, ECO 0000269|PubMed 16414944, ECO 0000269|PubMed 16922724, ECO 0000269|PubMed 18165683, ECO 0000269|PubMed 18400097, ECO 0000269|PubMed 19540844, ECO 0000269|PubMed 19716085, ECO 0000269|PubMed 21241800, ECO 0000269|PubMed 24184248, ECO 0000269|PubMed 24269949, ECO 0000269|PubMed 24713462, ECO 0000269|PubMed 25037568, ECO 0000269|PubMed 25139741, ECO 0000269|PubMed 25705178, ECO 0000269|PubMed 8528244, ECO 0000269|PubMed 8818942, ECO 0000269|PubMed 8872472, ECO 0000269|PubMed 9024139, ECO 0000269|PubMed 9272155, ECO 0000269|PubMed 9302275, ECO 0000269|PubMed 9312006, ECO 0000269|PubMed 9323054, ECO 0000269|PubMed 9386136, ECO 0000269|PubMed 9482580, ECO 0000269|PubMed 9570196, ECO 0000269|PubMed 9641694, ECO 0000269|PubMed 9693036, ECO 0000269|PubMed 9702906, ECO 0000269|PubMed 9799083, ECO 0000269|PubMed 9927399, ECO 0000269|Ref.31}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	KCNQ1_HUMAN	Short QT syndrome 2 (SQT2) [MIM 609621]  A heart disorder characterized by idiopathic persistently and uniformly short QT interval on ECG in the absence of structural heart disease in affected individuals. It causes syncope and sudden death. {ECO 0000269|PubMed 15159330}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	KCNQ1_HUMAN	The C-terminal assembly domain promotes self-interactiona; allows functional channel. {ECO 0000269|PubMed 10654932}. 
# DOMAIN	KCNQ1_HUMAN	The coiled-coil domain mediates tetramerization. {ECO 0000269|PubMed 18165683, ECO 0000269|PubMed 19693805}. 
# DOMAIN	KCNQ1_HUMAN	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. 
# DOMAIN	KCNQ1_HUMAN	The segment S6 is involved in the inhibition of voltage- gated potassium channel activity by KCNE4. {ECO 0000269|PubMed 19687231}. 
# DrugBank	DB00808	Indapamide
# DrugBank	DB01244	Bepridil
# Ensembl	ENST00000155840	ENSP00000155840; ENSG00000053918. [P51787-1]
# Ensembl	ENST00000335475	ENSP00000334497; ENSG00000053918. [P51787-2]
# ExpressionAtlas	P51787	baseline and differential
# FUNCTION	KCNQ1_HUMAN	Isoform 2  Non-functional alone but modulatory when coexpressed with the full-length isoform 1. {ECO 0000269|PubMed 9305853}. 
# FUNCTION	KCNQ1_HUMAN	Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity) (PubMed 10646604). Associates with KCNE beta subunits that modulates current kinetics (By similarity) (PubMed 9312006, PubMed 9108097, PubMed 8900283, PubMed 10646604, PubMed 11101505, PubMed 19687231). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity) (PubMed 9312006, PubMed 9108097, PubMed 8900283, PubMed 10646604, PubMed 11101505). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta- adrenergic receptor stimulation participates in cardiac repolarization by associating with KCNE1 to form the I(Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks) (By similarity) (PubMed 9312006, PubMed 9108097, PubMed 8900283, PubMed 10646604, PubMed 11101505). Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current (PubMed 10713961). When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions (PubMed 10646604). This interaction with KCNE3 is reduced by 17beta-estradiol, resulting in the reduction of currents (By similarity). During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion (By similarity). Allows the provision of potassium ions to the luminal membrane of the secretory canaliculus in the resting state as well as during stimulated acid secretion (By similarity). When associated with KCNE2, forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed 11101505). When associated with KCNE4, inhibits voltage-gated potassium channel activity (PubMed 19687231). When associated with KCNE5, this complex only conducts current upon strong and continued depolarization (PubMed 12324418). Also forms a heterotetramer with KCNQ5; has a voltage-gated potassium channel activity (PubMed 24855057). Binds with phosphatidylinositol 4,5- bisphosphate (PubMed 25037568). {ECO 0000250|UniProtKB P97414, ECO 0000250|UniProtKB Q9Z0N7, ECO 0000269|PubMed 10646604, ECO 0000269|PubMed 10713961, ECO 0000269|PubMed 11101505, ECO 0000269|PubMed 12324418, ECO 0000269|PubMed 19687231, ECO 0000269|PubMed 24855057, ECO 0000269|PubMed 25037568, ECO 0000269|PubMed 8900283, ECO 0000269|PubMed 9108097, ECO 0000269|PubMed 9312006}. 
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005764	lysosome; IDA:BHF-UCL.
# GO_component	GO:0005769	early endosome; IDA:BHF-UCL.
# GO_component	GO:0005770	late endosome; IDA:BHF-UCL.
# GO_component	GO:0005783	endoplasmic reticulum; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IDA:BHF-UCL.
# GO_component	GO:0016323	basolateral plasma membrane; IDA:UniProtKB.
# GO_component	GO:0030659	cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0034702	ion channel complex; IPI:UniProtKB.
# GO_component	GO:0045121	membrane raft; IDA:UniProtKB.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IDA:UniProtKB.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; IDA:UniProtKB.
# GO_function	GO:0005516	calmodulin binding; IDA:BHF-UCL.
# GO_function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding; IDA:UniProtKB.
# GO_function	GO:0008157	protein phosphatase 1 binding; IDA:BHF-UCL.
# GO_function	GO:0015271	outward rectifier potassium channel activity; IDA:UniProtKB.
# GO_function	GO:0034236	protein kinase A catalytic subunit binding; IDA:BHF-UCL.
# GO_function	GO:0034237	protein kinase A regulatory subunit binding; IDA:BHF-UCL.
# GO_function	GO:0044325	ion channel binding; IPI:UniProtKB.
# GO_function	GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization; IMP:BHF-UCL.
# GO_function	GO:0086089	voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization; IMP:BHF-UCL.
# GO_function	GO:0097110	scaffold protein binding; IPI:BHF-UCL.
# GO_function	GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization; IMP:BHF-UCL.
# GO_process	GO:0006349	regulation of gene expression by genetic imprinting; IEA:Ensembl.
# GO_process	GO:0007605	sensory perception of sound; TAS:ProtInc.
# GO_process	GO:0008016	regulation of heart contraction; IC:BHF-UCL.
# GO_process	GO:0010460	positive regulation of heart rate; IMP:BHF-UCL.
# GO_process	GO:0016458	gene silencing; IEA:Ensembl.
# GO_process	GO:0035690	cellular response to drug; IDA:BHF-UCL.
# GO_process	GO:0048839	inner ear development; ISS:UniProtKB.
# GO_process	GO:0050892	intestinal absorption; ISS:UniProtKB.
# GO_process	GO:0060048	cardiac muscle contraction; IMP:BHF-UCL.
# GO_process	GO:0060306	regulation of membrane repolarization; IDA:BHF-UCL.
# GO_process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization; IMP:BHF-UCL.
# GO_process	GO:0060372	regulation of atrial cardiac muscle cell membrane repolarization; IMP:BHF-UCL.
# GO_process	GO:0060452	positive regulation of cardiac muscle contraction; IMP:BHF-UCL.
# GO_process	GO:0060453	regulation of gastric acid secretion; ISS:UniProtKB.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:0070293	renal absorption; ISS:UniProtKB.
# GO_process	GO:0071320	cellular response to cAMP; IDA:BHF-UCL.
# GO_process	GO:0071435	potassium ion export; IDA:BHF-UCL.
# GO_process	GO:0071805	potassium ion transmembrane transport; IDA:BHF-UCL.
# GO_process	GO:0071872	cellular response to epinephrine stimulus; TAS:BHF-UCL.
# GO_process	GO:0072358	cardiovascular system development; IEA:Ensembl.
# GO_process	GO:0086005	ventricular cardiac muscle cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086011	membrane repolarization during action potential; IDA:BHF-UCL.
# GO_process	GO:0086013	membrane repolarization during cardiac muscle cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086014	atrial cardiac muscle cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086091	regulation of heart rate by cardiac conduction; IMP:BHF-UCL.
# GO_process	GO:0097623	potassium ion export across plasma membrane; IDA:BHF-UCL.
# GO_process	GO:0098915	membrane repolarization during ventricular cardiac muscle cell action potential; IMP:BHF-UCL.
# GO_process	GO:1901381	positive regulation of potassium ion transmembrane transport; IDA:BHF-UCL.
# GO_process	GO:1902260	negative regulation of delayed rectifier potassium channel activity; IDA:UniProtKB.
# GO_process	GO:1903817	negative regulation of voltage-gated potassium channel activity; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005764	lysosome
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008289	lipid binding
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P51787	HS
# HGNC	HGNC:6294	KCNQ1
# INTERACTION	KCNQ1_HUMAN	P15382 KCNE1; NbExp=4; IntAct=EBI-359667, EBI-7043557; 
# IntAct	P51787	4
# InterPro	IPR003937	K_chnl_volt-dep_KCNQ
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR005827	K_chnl_volt-dep_KCQN1
# InterPro	IPR013821	K_chnl_volt-dep_KCNQ_C
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00409	[Metabolic disease; Endocrine disease] Type II diabetes mellitus
# KEGG_Disease	H00720	[Cardiovascular disease] Jervell and Lange-Nielsen syndrome (JLNS)
# KEGG_Disease	H00725	[Cardiovascular disease] Short QT syndrome
# KEGG_Disease	H00731	[Cardiovascular disease] Atrial fibrillation
# KEGG_Pathway	ko04725	Cholinergic synapse
# KEGG_Pathway	ko04971	Gastric acid secretion
# KEGG_Pathway	ko04972	Pancreatic secretion
# KEGG_Pathway	ko04974	Protein digestion and absorption
# KEGG_Pathway	ko05110	Vibrio cholerae infection
# MIM	125853	phenotype
# MIM	192500	phenotype
# MIM	220400	phenotype
# MIM	607542	gene
# MIM	607554	phenotype
# MIM	609621	phenotype
# MISCELLANEOUS	KCNQ1_HUMAN	Mutagenesis experiments were carried out by expressing in Xenopus oocytes or COS-7 cells KCNQ1 mutants either individually (homomultimers) or in combination with both wild-type KCNQ1 (mut/wt homomultimers) and minK (heteromultimers). 
# Organism	KCNQ1_HUMAN	Homo sapiens (Human)
# Orphanet	101016	Romano-Ward syndrome
# Orphanet	334	Familial atrial fibrillation
# Orphanet	51083	Familial short QT syndrome
# Orphanet	90647	Jervell and Lange-Nielsen syndrome
# PANTHER	PTHR11537	PTHR11537; 2
# PANTHER	PTHR11537:SF151	PTHR11537:SF151; 2
# PDB	3BJ4	X-ray; 2.00 A; A/B=574-622
# PDB	3HFC	X-ray; 2.45 A; A/B/C=583-611
# PDB	3HFE	X-ray; 1.70 A; A/B/C=583-611
# PDB	4UMO	X-ray; 3.00 A; A/B=352-539
# PDB	4V0C	X-ray; 2.86 A; A/B=352-539
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01459	KCNQCHANNEL
# PRINTS	PR01460	KCNQ1CHANNEL
# PTM	KCNQ1_HUMAN	Deubiquitinated by USP2; counteracts the NEDD4L-specific down-regulation of I(Ks) and restores the membrane localization. {ECO 0000269|PubMed 22024150}. 
# PTM	KCNQ1_HUMAN	Phosphorylation at Ser-27 by PKA; increases delayed rectifier potassium channel activity of the KCNQ1-KCNE1 complex through a macromolecular complex that includes PKA, PP1, and the targeting protein AKAP9. {ECO 0000269|PubMed 11799244, ECO 0000269|PubMed 25037568}. 
# PTM	KCNQ1_HUMAN	Ubiquitinated by NEDD4L; promotes internalization (PubMed 22024150). The ubiquitinylated form is internalized through a clathrin-mediated endocytosis by interacting with AP2M1 and is recycled back to the cell membrane via RAB4A and RAB11A (PubMed 23529131). {ECO 0000269|PubMed 22024150, ECO 0000269|PubMed 23529131}. 
# Pfam	PF00520	Ion_trans
# Pfam	PF03520	KCNQ_channel
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# Reactome	R-HSA-5576890	Phase 3 - rapid repolarisation
# Reactome	R-HSA-5576893	Phase 2 - plateau phase
# RecName	Potassium voltage-gated channel subfamily KQT member 1 {ECO	0000305}
# RefSeq	NP_000209	NM_000218.2. [P51787-1]
# RefSeq	NP_861463	NM_181798.1. [P51787-2]
# SEQUENCE CAUTION	Sequence=AAC51781.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=BAA34739.1; Type=Frameshift; Positions=129, 159; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.1/KCNQ1 sub-subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	KCNQ1_HUMAN	Cell membrane {ECO 0000269|PubMed 10646604, ECO 0000269|PubMed 18165683, ECO 0000269|PubMed 21228319, ECO 0000269|PubMed 22024150, ECO 0000269|PubMed 25037568}; Multi- pass membrane protein {ECO 0000269|PubMed 18165683}. Cytoplasmic vesicle membrane {ECO 0000269|PubMed 18165683, ECO 0000269|PubMed 23529131}. Early endosome {ECO 0000269|PubMed 23529131}. Membrane raft {ECO 0000269|PubMed 20533308, ECO 0000269|PubMed 24855057}. Endoplasmic reticulum {ECO 0000269|PubMed 21228319, ECO 0000269|PubMed 24855057}. Basolateral cell membrane {ECO 0000269|PubMed 21228319}. Note=Colocalized with KCNE3 at the plasma membrane (PubMed 10646604). Upon 17beta-oestradiol treatment, colocalizes with RAB5A at early endosome (PubMed 23529131). Heterotetramer with KCNQ5 is highly retained at the endoplasmic reticulum and is localized outside of lipid raft microdomains (PubMed 24855057). During the early stages of epithelial cell polarization induced by the calcium switch it removed from plasma membrane to the endoplasmic reticulum where it retained and it is redistributed to the basolateral cell surface in a PI3K-dependent manner at a later stage (PubMed 21228319). {ECO 0000269|PubMed 10646604, ECO 0000269|PubMed 21228319, ECO 0000269|PubMed 23529131, ECO 0000269|PubMed 24855057}. 
# SUBUNIT	KCNQ1_HUMAN	Tetramer (PubMed 18165683, PubMed 19693805). Heterotetramer with KCNE1; targets to the membrane raft (PubMed 25037568, PubMed 19693805, PubMed 20533308). Interacts (via C-terminus) with CALM; forms a heterotetramer in a calcium- independent manner (PubMed 18165683). Interacts with AKAP9; targets protein kinase A (PKA) catalytic and regulatory subunits and protein phosphatase 1 (PP1) to the KCNQ1-KCNE1 complex, allowing PKA-mediated phosphorylation and increase of delayed rectifier potassium channel activity (PubMed 11799244, PubMed 25037568). Interacts with KCNE2; forms a heterooligomer complex that targets to the membrane raft and leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed 11101505, PubMed 20533308). Interacts with AP2M1; mediates estrogen-induced internalization via clathrin-coated vesicles (PubMed 23529131). Interacts with NEDD4L; promotes internalization and decreases I(Ks) currents (PubMed 23529131, PubMed 22024150). Interacts with USP2; counteracts the NEDD4L-specific down-regulation of I(Ks) and restore plasma membrane localization (PubMed 22024150). Heterotetramer with KCNQ5; has a voltage-gated potassium channel activity (PubMed 24855057). Interacts with KCNE3; alters membrane raft localization (PubMed 20533308). Interacts with KCNE4; impairs KCNQ1 localization in lipid rafts and inhibits voltage-gated potassium channel activity (PubMed 19687231, PubMed 20533308). Interacts with KCNE5; impairs KCNQ1 localization in lipid rafts and only conducts current upon strong and continued depolarization (PubMed 20533308, PubMed 12324418). {ECO 0000269|PubMed 11101505, ECO 0000269|PubMed 11799244, ECO 0000269|PubMed 12324418, ECO 0000269|PubMed 18165683, ECO 0000269|PubMed 19687231, ECO 0000269|PubMed 19693805, ECO 0000269|PubMed 20533308, ECO 0000269|PubMed 22024150, ECO 0000269|PubMed 23529131, ECO 0000269|PubMed 24855057, ECO 0000269|PubMed 25037568}. 
# TCDB	1.A.1.15	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	KCNQ1_HUMAN	Abundantly expressed in heart, pancreas, prostate, kidney, small intestine and peripheral blood leukocytes. Less abundant in placenta, lung, spleen, colon, thymus, testis and ovaries. 
# UCSC	uc001lwn	human. [P51787-1]
# WEB RESOURCE	KCNQ1_HUMAN	Name=Wikipedia; Note=KvLQT1 entry; URL="https //en.wikipedia.org/wiki/KvLQT1";
# eggNOG	COG1226	LUCA
# eggNOG	KOG1419	Eukaryota
BLAST	swissprot:KCNQ1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNQ1_HUMAN
BioCyc	ZFISH:ENSG00000053918-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000053918-MONOMER
COXPRESdb	3784	http://coxpresdb.jp/data/gene/3784.shtml
CleanEx	HS_KCNQ1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNQ1
DIP	DIP-27591N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-27591N
DIP	DIP-29941N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29941N
DOI	10.1001/jama.294.23.2975	http://dx.doi.org/10.1001/jama.294.23.2975
DOI	10.1002/(SICI)1096-8628(19990924)89:3<137::AID-AJMG4>3.3.CO	http://dx.doi.org/10.1002/(SICI)1096-8628(19990924)89:3<137::AID-AJMG4>3.3.CO
DOI	10.1002/(SICI)1098-1004(1998)11:2<158::AID-HUMU9>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1998)11:2<158::AID-HUMU9>3.0.CO
DOI	10.1002/(SICI)1098-1004(1999)13:4<301::AID-HUMU7>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1999)13:4<301::AID-HUMU7>3.0.CO
DOI	10.1002/(SICI)1098-1004(1999)13:4<318::AID-HUMU9>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1999)13:4<318::AID-HUMU9>3.0.CO
DOI	10.1002/humu.9085	http://dx.doi.org/10.1002/humu.9085
DOI	10.1002/jcp.22265	http://dx.doi.org/10.1002/jcp.22265
DOI	10.1002/pro.224	http://dx.doi.org/10.1002/pro.224
DOI	10.1006/geno.1998.5361	http://dx.doi.org/10.1006/geno.1998.5361
DOI	10.1007/s004390050516	http://dx.doi.org/10.1007/s004390050516
DOI	10.1007/s004390050819	http://dx.doi.org/10.1007/s004390050819
DOI	10.1016/S0006-3495(02)73961-1	http://dx.doi.org/10.1016/S0006-3495(02)73961-1
DOI	10.1016/S0008-6363(99)00411-3	http://dx.doi.org/10.1016/S0008-6363(99)00411-3
DOI	10.1016/j.bbadis.2011.01.008	http://dx.doi.org/10.1016/j.bbadis.2011.01.008
DOI	10.1016/j.hrthm.2005.01.020	http://dx.doi.org/10.1016/j.hrthm.2005.01.020
DOI	10.1016/j.hrthm.2009.05.021	http://dx.doi.org/10.1016/j.hrthm.2009.05.021
DOI	10.1016/j.hrthm.2011.10.026	http://dx.doi.org/10.1016/j.hrthm.2011.10.026
DOI	10.1016/j.hrthm.2013.11.021	http://dx.doi.org/10.1016/j.hrthm.2013.11.021
DOI	10.1016/j.jacc.2013.08.1648	http://dx.doi.org/10.1016/j.jacc.2013.08.1648
DOI	10.1016/j.yjmcc.2009.06.009	http://dx.doi.org/10.1016/j.yjmcc.2009.06.009
DOI	10.1016/j.yjmcc.2014.03.019	http://dx.doi.org/10.1016/j.yjmcc.2014.03.019
DOI	10.1038/35003200	http://dx.doi.org/10.1038/35003200
DOI	10.1038/384080a0	http://dx.doi.org/10.1038/384080a0
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1038/nature12828	http://dx.doi.org/10.1038/nature12828
DOI	10.1038/ng.207	http://dx.doi.org/10.1038/ng.207
DOI	10.1038/ng.208	http://dx.doi.org/10.1038/ng.208
DOI	10.1038/ng0196-17	http://dx.doi.org/10.1038/ng0196-17
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.ejhg.5200165	http://dx.doi.org/10.1038/sj.ejhg.5200165
DOI	10.1038/sj.ejhg.5200323	http://dx.doi.org/10.1038/sj.ejhg.5200323
DOI	10.1073/pnas.94.8.4017	http://dx.doi.org/10.1073/pnas.94.8.4017
DOI	10.1074/jbc.272.39.24109	http://dx.doi.org/10.1074/jbc.272.39.24109
DOI	10.1074/jbc.274.30.21063	http://dx.doi.org/10.1074/jbc.274.30.21063
DOI	10.1074/jbc.M707541200	http://dx.doi.org/10.1074/jbc.M707541200
DOI	10.1085/jgp.200910234	http://dx.doi.org/10.1085/jgp.200910234
DOI	10.1086/302346	http://dx.doi.org/10.1086/302346
DOI	10.1093/cvr/cvu191	http://dx.doi.org/10.1093/cvr/cvu191
DOI	10.1093/emboj/16.17.5472	http://dx.doi.org/10.1093/emboj/16.17.5472
DOI	10.1093/emboj/19.23.6326	http://dx.doi.org/10.1093/emboj/19.23.6326
DOI	10.1093/emboj/19.3.332	http://dx.doi.org/10.1093/emboj/19.3.332
DOI	10.1093/hmg/5.9.1319	http://dx.doi.org/10.1093/hmg/5.9.1319
DOI	10.1093/hmg/6.11.1943	http://dx.doi.org/10.1093/hmg/6.11.1943
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1399-0004.2006.00671.x	http://dx.doi.org/10.1111/j.1399-0004.2006.00671.x
DOI	10.1111/j.1469-7793.2000.t01-2-00349.x	http://dx.doi.org/10.1111/j.1469-7793.2000.t01-2-00349.x
DOI	10.1113/jphysiol.2013.251678	http://dx.doi.org/10.1113/jphysiol.2013.251678
DOI	10.1126/science.1066843	http://dx.doi.org/10.1126/science.1066843
DOI	10.1126/science.1077771	http://dx.doi.org/10.1126/science.1077771
DOI	10.1136/jmg.33.7.567	http://dx.doi.org/10.1136/jmg.33.7.567
DOI	10.1152/ajpcell.00390.2010	http://dx.doi.org/10.1152/ajpcell.00390.2010
DOI	10.1161/01.CIR.0000130409.72142.FE	http://dx.doi.org/10.1161/01.CIR.0000130409.72142.FE
DOI	10.1161/01.CIR.102.10.1178	http://dx.doi.org/10.1161/01.CIR.102.10.1178
DOI	10.1161/01.CIR.95.3.565	http://dx.doi.org/10.1161/01.CIR.95.3.565
DOI	10.1161/01.CIR.96.6.1733	http://dx.doi.org/10.1161/01.CIR.96.6.1733
DOI	10.1161/01.CIR.96.9.2778	http://dx.doi.org/10.1161/01.CIR.96.9.2778
DOI	10.1161/01.CIR.97.13.1264	http://dx.doi.org/10.1161/01.CIR.97.13.1264
DOI	10.1161/01.CIR.97.24.2420	http://dx.doi.org/10.1161/01.CIR.97.24.2420
DOI	10.1161/01.CIR.99.4.529	http://dx.doi.org/10.1161/01.CIR.99.4.529
DOI	10.1161/01.RES.84.3.290	http://dx.doi.org/10.1161/01.RES.84.3.290
DOI	10.1161/ATVBAHA.114.303801	http://dx.doi.org/10.1161/ATVBAHA.114.303801
DOI	10.1186/1471-2350-9-24	http://dx.doi.org/10.1186/1471-2350-9-24
DOI	10.1203/00006450-199808000-00002	http://dx.doi.org/10.1203/00006450-199808000-00002
DOI	10.1242/jcs.147033	http://dx.doi.org/10.1242/jcs.147033
DOI	10.1253/circj.72.687	http://dx.doi.org/10.1253/circj.72.687
DOI	10.3389/fncel.2015.00032	http://dx.doi.org/10.3389/fncel.2015.00032
DrugBank	DB00808	http://www.drugbank.ca/drugs/DB00808
DrugBank	DB01244	http://www.drugbank.ca/drugs/DB01244
EMBL	AB015163	http://www.ebi.ac.uk/ena/data/view/AB015163
EMBL	AB015163	http://www.ebi.ac.uk/ena/data/view/AB015163
EMBL	AC013791	http://www.ebi.ac.uk/ena/data/view/AC013791
EMBL	AC021424	http://www.ebi.ac.uk/ena/data/view/AC021424
EMBL	AC124055	http://www.ebi.ac.uk/ena/data/view/AC124055
EMBL	AC124057	http://www.ebi.ac.uk/ena/data/view/AC124057
EMBL	AF000571	http://www.ebi.ac.uk/ena/data/view/AF000571
EMBL	AF051426	http://www.ebi.ac.uk/ena/data/view/AF051426
EMBL	AJ006345	http://www.ebi.ac.uk/ena/data/view/AJ006345
EMBL	AJ006345	http://www.ebi.ac.uk/ena/data/view/AJ006345
EMBL	AK290618	http://www.ebi.ac.uk/ena/data/view/AK290618
EMBL	AP006463	http://www.ebi.ac.uk/ena/data/view/AP006463
EMBL	AY114213	http://www.ebi.ac.uk/ena/data/view/AY114213
EMBL	BC113545	http://www.ebi.ac.uk/ena/data/view/BC113545
EMBL	CH471158	http://www.ebi.ac.uk/ena/data/view/CH471158
EMBL	KF455303	http://www.ebi.ac.uk/ena/data/view/KF455303
EMBL	KF455304	http://www.ebi.ac.uk/ena/data/view/KF455304
EMBL	KF455305	http://www.ebi.ac.uk/ena/data/view/KF455305
EMBL	KF455306	http://www.ebi.ac.uk/ena/data/view/KF455306
EMBL	KF459741	http://www.ebi.ac.uk/ena/data/view/KF459741
EMBL	U86146	http://www.ebi.ac.uk/ena/data/view/U86146
EMBL	U89364	http://www.ebi.ac.uk/ena/data/view/U89364
Ensembl	ENST00000155840	http://www.ensembl.org/id/ENST00000155840
Ensembl	ENST00000335475	http://www.ensembl.org/id/ENST00000335475
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GO_component	GO:0005769	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005769
GO_component	GO:0005770	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005770
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0030659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030659
GO_component	GO:0034702	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034702
GO_component	GO:0045121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045121
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_function	GO:0005516	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005516
GO_function	GO:0005546	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005546
GO_function	GO:0008157	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008157
GO_function	GO:0015271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015271
GO_function	GO:0034236	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034236
GO_function	GO:0034237	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034237
GO_function	GO:0044325	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044325
GO_function	GO:0086008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086008
GO_function	GO:0086089	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086089
GO_function	GO:0097110	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097110
GO_function	GO:1902282	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902282
GO_process	GO:0006349	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006349
GO_process	GO:0007605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007605
GO_process	GO:0008016	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008016
GO_process	GO:0010460	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010460
GO_process	GO:0016458	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016458
GO_process	GO:0035690	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035690
GO_process	GO:0048839	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048839
GO_process	GO:0050892	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050892
GO_process	GO:0060048	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060048
GO_process	GO:0060306	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060306
GO_process	GO:0060307	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060307
GO_process	GO:0060372	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060372
GO_process	GO:0060452	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060452
GO_process	GO:0060453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060453
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:0070293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070293
GO_process	GO:0071320	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071320
GO_process	GO:0071435	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071435
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GO_process	GO:0071872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071872
GO_process	GO:0072358	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072358
GO_process	GO:0086005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086005
GO_process	GO:0086011	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086011
GO_process	GO:0086013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086013
GO_process	GO:0086014	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086014
GO_process	GO:0086091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086091
GO_process	GO:0097623	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097623
GO_process	GO:0098915	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098915
GO_process	GO:1901381	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901381
GO_process	GO:1902260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902260
GO_process	GO:1903817	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903817
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	KCNQ1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNQ1
GeneID	3784	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3784
GeneTree	ENSGT00550000074513	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074513
HGNC	HGNC:6294	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6294
HOGENOM	HOG000220839	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220839&db=HOGENOM6
HOVERGEN	HBG059014	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG059014&db=HOVERGEN
HPA	CAB018656	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB018656
HPA	HPA048553	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA048553
InParanoid	P51787	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P51787
IntAct	P51787	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P51787*
InterPro	IPR003937	http://www.ebi.ac.uk/interpro/entry/IPR003937
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR005827	http://www.ebi.ac.uk/interpro/entry/IPR005827
InterPro	IPR013821	http://www.ebi.ac.uk/interpro/entry/IPR013821
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	3784	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3784
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00409	http://www.genome.jp/dbget-bin/www_bget?H00409
KEGG_Disease	H00720	http://www.genome.jp/dbget-bin/www_bget?H00720
KEGG_Disease	H00725	http://www.genome.jp/dbget-bin/www_bget?H00725
KEGG_Disease	H00731	http://www.genome.jp/dbget-bin/www_bget?H00731
KEGG_Gene	hsa:3784	http://www.genome.jp/dbget-bin/www_bget?hsa:3784
KEGG_Orthology	KO:K04926	http://www.genome.jp/dbget-bin/www_bget?KO:K04926
KEGG_Pathway	ko04725	http://www.genome.jp/kegg-bin/show_pathway?ko04725
KEGG_Pathway	ko04971	http://www.genome.jp/kegg-bin/show_pathway?ko04971
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
KEGG_Pathway	ko04974	http://www.genome.jp/kegg-bin/show_pathway?ko04974
KEGG_Pathway	ko05110	http://www.genome.jp/kegg-bin/show_pathway?ko05110
MIM	125853	http://www.ncbi.nlm.nih.gov/omim/125853
MIM	192500	http://www.ncbi.nlm.nih.gov/omim/192500
MIM	220400	http://www.ncbi.nlm.nih.gov/omim/220400
MIM	607542	http://www.ncbi.nlm.nih.gov/omim/607542
MIM	607554	http://www.ncbi.nlm.nih.gov/omim/607554
MIM	609621	http://www.ncbi.nlm.nih.gov/omim/609621
MINT	MINT-1145466	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1145466
OMA	EVSTPHF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EVSTPHF
Orphanet	101016	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=101016
Orphanet	334	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=334
Orphanet	51083	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=51083
Orphanet	90647	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=90647
OrthoDB	EOG091G02ZT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02ZT
PANTHER	PTHR11537	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537
PANTHER	PTHR11537:SF151	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537:SF151
PDB	3BJ4	http://www.ebi.ac.uk/pdbe-srv/view/entry/3BJ4
PDB	3HFC	http://www.ebi.ac.uk/pdbe-srv/view/entry/3HFC
PDB	3HFE	http://www.ebi.ac.uk/pdbe-srv/view/entry/3HFE
PDB	4UMO	http://www.ebi.ac.uk/pdbe-srv/view/entry/4UMO
PDB	4V0C	http://www.ebi.ac.uk/pdbe-srv/view/entry/4V0C
PDBsum	3BJ4	http://www.ebi.ac.uk/pdbsum/3BJ4
PDBsum	3HFC	http://www.ebi.ac.uk/pdbsum/3HFC
PDBsum	3HFE	http://www.ebi.ac.uk/pdbsum/3HFE
PDBsum	4UMO	http://www.ebi.ac.uk/pdbsum/4UMO
PDBsum	4V0C	http://www.ebi.ac.uk/pdbsum/4V0C
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01459	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01459
PRINTS	PR01460	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01460
PSORT	swissprot:KCNQ1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNQ1_HUMAN
PSORT-B	swissprot:KCNQ1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNQ1_HUMAN
PSORT2	swissprot:KCNQ1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNQ1_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF03520	http://pfam.xfam.org/family/PF03520
PharmGKB	PA223	http://www.pharmgkb.org/do/serve?objId=PA223&objCls=Gene
Phobius	swissprot:KCNQ1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNQ1_HUMAN
PhylomeDB	P51787	http://phylomedb.org/?seqid=P51787
ProteinModelPortal	P51787	http://www.proteinmodelportal.org/query/uniprot/P51787
PubMed	10024302	http://www.ncbi.nlm.nih.gov/pubmed/10024302
PubMed	10090886	http://www.ncbi.nlm.nih.gov/pubmed/10090886
PubMed	10220144	http://www.ncbi.nlm.nih.gov/pubmed/10220144
PubMed	10220146	http://www.ncbi.nlm.nih.gov/pubmed/10220146
PubMed	10367071	http://www.ncbi.nlm.nih.gov/pubmed/10367071
PubMed	10409658	http://www.ncbi.nlm.nih.gov/pubmed/10409658
PubMed	10482963	http://www.ncbi.nlm.nih.gov/pubmed/10482963
PubMed	10646604	http://www.ncbi.nlm.nih.gov/pubmed/10646604
PubMed	10654932	http://www.ncbi.nlm.nih.gov/pubmed/10654932
PubMed	10704188	http://www.ncbi.nlm.nih.gov/pubmed/10704188
PubMed	10713961	http://www.ncbi.nlm.nih.gov/pubmed/10713961
PubMed	10728423	http://www.ncbi.nlm.nih.gov/pubmed/10728423
PubMed	10973849	http://www.ncbi.nlm.nih.gov/pubmed/10973849
PubMed	11101505	http://www.ncbi.nlm.nih.gov/pubmed/11101505
PubMed	11799244	http://www.ncbi.nlm.nih.gov/pubmed/11799244
PubMed	12324418	http://www.ncbi.nlm.nih.gov/pubmed/12324418
PubMed	12442276	http://www.ncbi.nlm.nih.gov/pubmed/12442276
PubMed	12522251	http://www.ncbi.nlm.nih.gov/pubmed/12522251
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15159330	http://www.ncbi.nlm.nih.gov/pubmed/15159330
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15840476	http://www.ncbi.nlm.nih.gov/pubmed/15840476
PubMed	16414944	http://www.ncbi.nlm.nih.gov/pubmed/16414944
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	16922724	http://www.ncbi.nlm.nih.gov/pubmed/16922724
PubMed	18165683	http://www.ncbi.nlm.nih.gov/pubmed/18165683
PubMed	18400097	http://www.ncbi.nlm.nih.gov/pubmed/18400097
PubMed	18441444	http://www.ncbi.nlm.nih.gov/pubmed/18441444
PubMed	18711366	http://www.ncbi.nlm.nih.gov/pubmed/18711366
PubMed	18711367	http://www.ncbi.nlm.nih.gov/pubmed/18711367
PubMed	19540844	http://www.ncbi.nlm.nih.gov/pubmed/19540844
PubMed	19687231	http://www.ncbi.nlm.nih.gov/pubmed/19687231
PubMed	19693805	http://www.ncbi.nlm.nih.gov/pubmed/19693805
PubMed	19716085	http://www.ncbi.nlm.nih.gov/pubmed/19716085
PubMed	20533308	http://www.ncbi.nlm.nih.gov/pubmed/20533308
PubMed	21228319	http://www.ncbi.nlm.nih.gov/pubmed/21228319
PubMed	21241800	http://www.ncbi.nlm.nih.gov/pubmed/21241800
PubMed	22024150	http://www.ncbi.nlm.nih.gov/pubmed/22024150
PubMed	23529131	http://www.ncbi.nlm.nih.gov/pubmed/23529131
PubMed	24184248	http://www.ncbi.nlm.nih.gov/pubmed/24184248
PubMed	24269949	http://www.ncbi.nlm.nih.gov/pubmed/24269949
PubMed	24390345	http://www.ncbi.nlm.nih.gov/pubmed/24390345
PubMed	24713462	http://www.ncbi.nlm.nih.gov/pubmed/24713462
PubMed	24855057	http://www.ncbi.nlm.nih.gov/pubmed/24855057
PubMed	25037568	http://www.ncbi.nlm.nih.gov/pubmed/25037568
PubMed	25139741	http://www.ncbi.nlm.nih.gov/pubmed/25139741
PubMed	25705178	http://www.ncbi.nlm.nih.gov/pubmed/25705178
PubMed	8528244	http://www.ncbi.nlm.nih.gov/pubmed/8528244
PubMed	8818942	http://www.ncbi.nlm.nih.gov/pubmed/8818942
PubMed	8872472	http://www.ncbi.nlm.nih.gov/pubmed/8872472
PubMed	8900283	http://www.ncbi.nlm.nih.gov/pubmed/8900283
PubMed	9024139	http://www.ncbi.nlm.nih.gov/pubmed/9024139
PubMed	9108097	http://www.ncbi.nlm.nih.gov/pubmed/9108097
PubMed	9272155	http://www.ncbi.nlm.nih.gov/pubmed/9272155
PubMed	9302275	http://www.ncbi.nlm.nih.gov/pubmed/9302275
PubMed	9305853	http://www.ncbi.nlm.nih.gov/pubmed/9305853
PubMed	9312006	http://www.ncbi.nlm.nih.gov/pubmed/9312006
PubMed	9323054	http://www.ncbi.nlm.nih.gov/pubmed/9323054
PubMed	9386136	http://www.ncbi.nlm.nih.gov/pubmed/9386136
PubMed	9482580	http://www.ncbi.nlm.nih.gov/pubmed/9482580
PubMed	9570196	http://www.ncbi.nlm.nih.gov/pubmed/9570196
PubMed	9641694	http://www.ncbi.nlm.nih.gov/pubmed/9641694
PubMed	9693036	http://www.ncbi.nlm.nih.gov/pubmed/9693036
PubMed	9702906	http://www.ncbi.nlm.nih.gov/pubmed/9702906
PubMed	9781056	http://www.ncbi.nlm.nih.gov/pubmed/9781056
PubMed	9799083	http://www.ncbi.nlm.nih.gov/pubmed/9799083
PubMed	9927399	http://www.ncbi.nlm.nih.gov/pubmed/9927399
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
Reactome	R-HSA-5576890	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576890
Reactome	R-HSA-5576893	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576893
RefSeq	NP_000209	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000209
RefSeq	NP_861463	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_861463
SMR	P51787	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P51787
STRING	9606.ENSP00000155840	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000155840&targetmode=cogs
TCDB	1.A.1.15	http://www.tcdb.org/search/result.php?tc=1.A.1.15
UCSC	uc001lwn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001lwn&org=rat
UniGene	Hs.95162	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.95162
UniProtKB	KCNQ1_HUMAN	http://www.uniprot.org/uniprot/KCNQ1_HUMAN
UniProtKB-AC	P51787	http://www.uniprot.org/uniprot/P51787
charge	swissprot:KCNQ1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNQ1_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG1419	http://eggnogapi.embl.de/nog_data/html/tree/KOG1419
epestfind	swissprot:KCNQ1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNQ1_HUMAN
garnier	swissprot:KCNQ1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNQ1_HUMAN
helixturnhelix	swissprot:KCNQ1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNQ1_HUMAN
hmoment	swissprot:KCNQ1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNQ1_HUMAN
iep	swissprot:KCNQ1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNQ1_HUMAN
inforesidue	swissprot:KCNQ1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNQ1_HUMAN
neXtProt	NX_P51787	http://www.nextprot.org/db/entry/NX_P51787
octanol	swissprot:KCNQ1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNQ1_HUMAN
pepcoil	swissprot:KCNQ1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNQ1_HUMAN
pepdigest	swissprot:KCNQ1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNQ1_HUMAN
pepinfo	swissprot:KCNQ1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNQ1_HUMAN
pepnet	swissprot:KCNQ1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNQ1_HUMAN
pepstats	swissprot:KCNQ1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNQ1_HUMAN
pepwheel	swissprot:KCNQ1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNQ1_HUMAN
pepwindow	swissprot:KCNQ1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNQ1_HUMAN
sigcleave	swissprot:KCNQ1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNQ1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	OPRM_HUMAN	Event=Alternative splicing; Named isoforms=18; Comment=Additional isoforms seem to exist.; Name=1; IsoId=P35372-1; Sequence=Displayed; Name=2; Synonyms=MOR1A, MOR-1A; IsoId=P35372-2; Sequence=VSP_001896; Name=3; Synonyms=MOR-1R, MOR-1X; IsoId=P35372-3; Sequence=VSP_037695; Note=Ref.4 (AAK74189) sequence is in conflict in position  402 Q->H. {ECO 0000305}; Name=4; Synonyms=MOR-1B3; IsoId=P35372-4; Sequence=VSP_037696; Name=5; Synonyms=MOR-1C, MOR-1O; IsoId=P35372-5; Sequence=VSP_037697; Name=6; Synonyms=MOR-1V, MOR-1Y, MOR-1Y2, MOR-1Y3; IsoId=P35372-6; Sequence=VSP_037698; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=7; Synonyms=MOR-1B1; IsoId=P35372-7; Sequence=VSP_037699; Name=8; Synonyms=MOR-1B2; IsoId=P35372-8; Sequence=VSP_037700; Name=9; Synonyms=MOR-1B5; IsoId=P35372-9; Sequence=VSP_037701; Note=Ref.5 (AAQ77392) sequence differs from that shown due to a polymorphism leading to premature termination of translation (position  411 Q->Stop). {ECO 0000305}; Name=10; Synonyms=MOR-1i; IsoId=P35372-10; Sequence=VSP_037693; Name=11; Synonyms=MOR-1B4; IsoId=P35372-11; Sequence=VSP_037694; Name=12; Synonyms=MOR-1G1, MOR-1K; IsoId=P35372-12; Sequence=VSP_042327; Name=13; Synonyms=MOR-1G2; IsoId=P35372-13; Sequence=VSP_042328; Name=14; Synonyms=Mu3; IsoId=P35372-14; Sequence=VSP_042327, VSP_042331; Name=15; Synonyms=MOR-1W; IsoId=P35372-15; Sequence=VSP_042327, VSP_001896; Name=16; Synonyms=SV1; IsoId=P35372-16; Sequence=VSP_042330; Name=17; Synonyms=SV2; IsoId=P35372-17; Sequence=VSP_042329; Name=18; Synonyms=hMOR-1Z; IsoId=P35372-18; Sequence=VSP_047577, VSP_047578; 
# AltName	OPRM_HUMAN	Mu opiate receptor
# AltName	OPRM_HUMAN	Mu opioid receptor
# BioGrid	111033	73
# CCDS	CCDS43517	-. [P35372-5]
# CCDS	CCDS43518	-. [P35372-3]
# CCDS	CCDS47503	-. [P35372-10]
# CCDS	CCDS47504	-. [P35372-7]
# CCDS	CCDS47505	-. [P35372-8]
# CCDS	CCDS47506	-. [P35372-4]
# CCDS	CCDS47507	-. [P35372-9]
# CCDS	CCDS47508	-. [P35372-2]
# CCDS	CCDS55068	-. [P35372-13]
# CCDS	CCDS55069	-. [P35372-11]
# CCDS	CCDS55070	-. [P35372-1]
# CCDS	CCDS55071	-. [P35372-12]
# DrugBank	DB00193	Tramadol
# DrugBank	DB00295	Morphine
# DrugBank	DB00318	Codeine
# DrugBank	DB00321	Amitriptyline
# DrugBank	DB00327	Hydromorphone
# DrugBank	DB00333	Methadone
# DrugBank	DB00454	Pethidine
# DrugBank	DB00497	Oxycodone
# DrugBank	DB00504	Levallorphan
# DrugBank	DB00514	Dextromethorphan
# DrugBank	DB00611	Butorphanol
# DrugBank	DB00647	Dextropropoxyphene
# DrugBank	DB00652	Pentazocine
# DrugBank	DB00704	Naltrexone
# DrugBank	DB00708	Sufentanil
# DrugBank	DB00802	Alfentanil
# DrugBank	DB00813	Fentanyl
# DrugBank	DB00836	Loperamide
# DrugBank	DB00844	Nalbuphine
# DrugBank	DB00854	Levorphanol
# DrugBank	DB00899	Remifentanil
# DrugBank	DB00904	Ondansetron
# DrugBank	DB00913	Anileridine
# DrugBank	DB00921	Buprenorphine
# DrugBank	DB00956	Hydrocodone
# DrugBank	DB01081	Diphenoxylate
# DrugBank	DB01183	Naloxone
# DrugBank	DB01192	Oxymorphone
# DrugBank	DB01209	Dezocine
# DrugBank	DB01221	Ketamine
# DrugBank	DB01227	Levomethadyl Acetate
# DrugBank	DB01433	Methadyl Acetate
# DrugBank	DB01452	Heroin
# DrugBank	DB01466	Ethylmorphine
# DrugBank	DB06204	Tapentadol
# DrugBank	DB06274	Alvimopan
# DrugBank	DB06738	Ketobemidone
# DrugBank	DB06800	Methylnaltrexone
# DrugBank	DB09049	Naloxegol
# DrugBank	DB09272	Eluxadoline
# Ensembl	ENST00000229768	ENSP00000229768; ENSG00000112038. [P35372-3]
# Ensembl	ENST00000330432	ENSP00000328264; ENSG00000112038. [P35372-1]
# Ensembl	ENST00000337049	ENSP00000338381; ENSG00000112038. [P35372-5]
# Ensembl	ENST00000414028	ENSP00000399359; ENSG00000112038. [P35372-4]
# Ensembl	ENST00000419506	ENSP00000403549; ENSG00000112038. [P35372-9]
# Ensembl	ENST00000428397	ENSP00000411903; ENSG00000112038. [P35372-2]
# Ensembl	ENST00000434900	ENSP00000394624; ENSG00000112038. [P35372-10]
# Ensembl	ENST00000435918	ENSP00000413752; ENSG00000112038. [P35372-8]
# Ensembl	ENST00000452687	ENSP00000410497; ENSG00000112038. [P35372-7]
# Ensembl	ENST00000518759	ENSP00000430260; ENSG00000112038. [P35372-13]
# Ensembl	ENST00000519083	ENSP00000431048; ENSG00000112038. [P35372-6]
# Ensembl	ENST00000520708	ENSP00000430876; ENSG00000112038. [P35372-12]
# Ensembl	ENST00000522236	ENSP00000429373; ENSG00000112038. [P35372-12]
# Ensembl	ENST00000522555	ENSP00000429719; ENSG00000112038. [P35372-12]
# Ensembl	ENST00000522739	ENSP00000428018; ENSG00000112038. [P35372-6]
# Ensembl	ENST00000524150	ENSP00000430575; ENSG00000112038. [P35372-18]
# Ensembl	ENST00000524163	ENSP00000430097; ENSG00000112038. [P35372-11]
# ExpressionAtlas	P35372	baseline and differential
# FUNCTION	OPRM_HUMAN	Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta- gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist- specific receptor phosphorylation. Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling. Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling whereas morphine induces only low desensitization and endocytosis. Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties. Involved in neurogenesis. Isoform 12 couples to GNAS and is proposed to be involved in excitatory effects. Isoform 16 and isoform 17 do not bind agonists but may act through oligomerization with binding- competent OPRM1 isoforms and reduce their ligand binding activity. 
# GO_component	GO:0005623	cell; IEA:GOC.
# GO_component	GO:0005783	endoplasmic reticulum; TAS:ProtInc.
# GO_component	GO:0005794	Golgi apparatus; TAS:ProtInc.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0005925	focal adhesion; IEA:Ensembl.
# GO_component	GO:0032590	dendrite membrane; IEA:Ensembl.
# GO_component	GO:0032839	dendrite cytoplasm; IEA:Ensembl.
# GO_component	GO:0042383	sarcolemma; IEA:Ensembl.
# GO_component	GO:0043005	neuron projection; IBA:GO_Central.
# GO_component	GO:0043204	perikaryon; IEA:Ensembl.
# GO_component	GO:0045121	membrane raft; IEA:Ensembl.
# GO_component	GO:0098794	postsynapse; IEA:GOC.
# GO_function	GO:0001965	G-protein alpha-subunit binding; IDA:UniProtKB.
# GO_function	GO:0004930	G-protein coupled receptor activity; ISS:UniProtKB.
# GO_function	GO:0004979	beta-endorphin receptor activity; IMP:UniProtKB.
# GO_function	GO:0005245	voltage-gated calcium channel activity; ISS:UniProtKB.
# GO_function	GO:0031681	G-protein beta-subunit binding; IBA:GO_Central.
# GO_function	GO:0038047	morphine receptor activity; ISS:UniProtKB.
# GO_function	GO:0042923	neuropeptide binding; IBA:GO_Central.
# GO_process	GO:0002438	acute inflammatory response to antigenic stimulus; IEA:Ensembl.
# GO_process	GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; TAS:ProtInc.
# GO_process	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway; IEA:Ensembl.
# GO_process	GO:0007194	negative regulation of adenylate cyclase activity; ISS:UniProtKB.
# GO_process	GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway; ISS:UniProtKB.
# GO_process	GO:0007204	positive regulation of cytosolic calcium ion concentration; IDA:UniProtKB.
# GO_process	GO:0007268	chemical synaptic transmission; IBA:GO_Central.
# GO_process	GO:0007600	sensory perception; NAS:UniProtKB.
# GO_process	GO:0007626	locomotory behavior; IEA:Ensembl.
# GO_process	GO:0008285	negative regulation of cell proliferation; TAS:ProtInc.
# GO_process	GO:0009314	response to radiation; IEA:Ensembl.
# GO_process	GO:0019233	sensory perception of pain; ISS:UniProtKB.
# GO_process	GO:0031635	adenylate cyclase-inhibiting opioid receptor signaling pathway; IEA:Ensembl.
# GO_process	GO:0032094	response to food; IEA:Ensembl.
# GO_process	GO:0032100	positive regulation of appetite; IEA:Ensembl.
# GO_process	GO:0032496	response to lipopolysaccharide; IEA:Ensembl.
# GO_process	GO:0033554	cellular response to stress; IMP:UniProtKB.
# GO_process	GO:0042060	wound healing; IEA:Ensembl.
# GO_process	GO:0042220	response to cocaine; IEA:Ensembl.
# GO_process	GO:0042755	eating behavior; IEA:Ensembl.
# GO_process	GO:0043950	positive regulation of cAMP-mediated signaling; IDA:UniProtKB.
# GO_process	GO:0043951	negative regulation of cAMP-mediated signaling; IDA:UniProtKB.
# GO_process	GO:0044849	estrous cycle; IEA:Ensembl.
# GO_process	GO:0045019	negative regulation of nitric oxide biosynthetic process; IDA:UniProtKB.
# GO_process	GO:0045429	positive regulation of nitric oxide biosynthetic process; IDA:UniProtKB.
# GO_process	GO:0048149	behavioral response to ethanol; IMP:UniProtKB.
# GO_process	GO:0050769	positive regulation of neurogenesis; ISS:UniProtKB.
# GO_process	GO:0051481	negative regulation of cytosolic calcium ion concentration; IDA:UniProtKB.
# GO_process	GO:0051930	regulation of sensory perception of pain; IEA:Ensembl.
# GO_process	GO:0060079	excitatory postsynaptic potential; IEA:Ensembl.
# GO_process	GO:0061358	negative regulation of Wnt protein secretion; IMP:UniProtKB.
# GO_process	GO:0070374	positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
# GO_process	GO:0070848	response to growth factor; IEA:Ensembl.
# GO_process	GO:0071315	cellular response to morphine; IBA:GO_Central.
# GO_process	GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005623	cell
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0050877	neurological system process
# Genevisible	P35372	HS
# HGNC	HGNC:8156	OPRM1
# INTERACTION	OPRM_HUMAN	Q9Y679 AUP1; NbExp=4; IntAct=EBI-2624570, EBI-1058701; Q92905 COPS5; NbExp=5; IntAct=EBI-2624570, EBI-594661; Q8TEW6 DOK4; NbExp=4; IntAct=EBI-2624570, EBI-6918542; P21333 FLNA; NbExp=5; IntAct=EBI-2624570, EBI-350432; P35212 GJA4; NbExp=2; IntAct=EBI-2624570, EBI-6918707; P01210 PENK; NbExp=3; IntAct=EBI-2624570, EBI-6656055; Q96S59 RANBP9; NbExp=5; IntAct=EBI-2624570, EBI-636085; Q8IUQ4 SIAH1; NbExp=4; IntAct=EBI-2624570, EBI-747107; O43255 SIAH2; NbExp=3; IntAct=EBI-2624570, EBI-948141; Q9P0L0 VAPA; NbExp=3; IntAct=EBI-2624570, EBI-1059156; Q5T9L3 WLS; NbExp=10; IntAct=EBI-2624570, EBI-2868748; Q15942 ZYX; NbExp=2; IntAct=EBI-2624570, EBI-444225; 
# IntAct	P35372	15
# InterPro	IPR000105	Mu_opioid_rcpt
# InterPro	IPR000276	GPCR_Rhodpsn
# InterPro	IPR001418	Opioid_rcpt
# InterPro	IPR017452	GPCR_Rhodpsn_7TM
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04030	 G protein-coupled receptors
# KEGG_Disease	H01611	[Nervous system diseases; Other nervous system diseases] Alcohol dependence
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko05032	Morphine addiction
# MIM	600018	gene
# MISCELLANEOUS	OPRM_HUMAN	OPRM1 is the main physiological target for most clinically important opioid analgesics. OPRM1-mediated inhibition of voltage-gated calcium channels on central presynaptic terminals of primary afferent nociceptors is thought to be one of the primary mechanisms mediating analgesia at the spinal level. Opioid-induced hyperalgesic responses are observed following both acute and chronic dosing associated with cellular excitation. 
# Organism	OPRM_HUMAN	Homo sapiens (Human)
# PIR	I56553	I56553
# PIR	S65693	S65693
# POLYMORPHISM	OPRM_HUMAN	Variant Asp-40 does not show altered binding affinities for most opioid peptides and alkaloids tested, but it binds beta-endorphin, an endogenous opioid that activates the mu opioid receptor, approximately 3 times more tightly than the most common allelic form. 
# PRINTS	PR00237	GPCRRHODOPSN
# PRINTS	PR00384	OPIOIDR
# PRINTS	PR00537	MUOPIOIDR
# PROSITE	PS00237	G_PROTEIN_RECEP_F1_1
# PROSITE	PS50262	G_PROTEIN_RECEP_F1_2
# PTM	OPRM_HUMAN	Phosphorylated. Differentially phosphorylated in basal and agonist-induced conditions. Agonist-mediated phosphorylation modulates receptor internalization. Phosphorylated by GRK2 in a agonist-dependent manner. Phosphorylation at Tyr-168 requires receptor activation, is dependent on non-receptor protein tyrosine kinase Src and results in a decrease in agonist efficacy by reducing G-protein coupling efficiency. Phosphorylated on tyrosine residues; the phosphorylation is involved in agonist-induced G- protein-independent receptor down-regulation. Phosphorylation at Ser-377 is involved in G-protein-dependent but not beta-arrestin- dependent activation of the ERK pathway (By similarity). {ECO 0000250}. 
# PTM	OPRM_HUMAN	Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1 OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4 (By similarity). {ECO 0000250}. 
# Pfam	PF00001	7tm_1
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-111885	Opioid Signalling
# Reactome	R-HSA-202040	G-protein activation
# Reactome	R-HSA-375276	Peptide ligand-binding receptors
# Reactome	R-HSA-418594	G alpha (i) signalling events
# RecName	OPRM_HUMAN	Mu-type opioid receptor
# RefSeq	NP_000905	NM_000914.4. [P35372-1]
# RefSeq	NP_001008503	NM_001008503.2. [P35372-5]
# RefSeq	NP_001008504	NM_001008504.3. [P35372-2]
# RefSeq	NP_001008505	NM_001008505.2. [P35372-3]
# RefSeq	NP_001138751	NM_001145279.3. [P35372-10]
# RefSeq	NP_001138752	NM_001145280.3. [P35372-12]
# RefSeq	NP_001138753	NM_001145281.2. [P35372-13]
# RefSeq	NP_001138754	NM_001145282.2. [P35372-7]
# RefSeq	NP_001138755	NM_001145283.2. [P35372-8]
# RefSeq	NP_001138756	NM_001145284.3. [P35372-4]
# RefSeq	NP_001138757	NM_001145285.2. [P35372-11]
# RefSeq	NP_001138758	NM_001145286.2. [P35372-9]
# RefSeq	NP_001138759	NM_001145287.2. [P35372-12]
# RefSeq	NP_001272452	NM_001285523.1
# RefSeq	NP_001272453	NM_001285524.1. [P35372-10]
# RefSeq	NP_001272455	NM_001285526.1. [P35372-12]
# RefSeq	NP_001272456	NM_001285527.1. [P35372-15]
# RefSeq	NP_001272457	NM_001285528.1. [P35372-14]
# RefSeq	XP_016866395	XM_017010906.1. [P35372-12]
# SEQUENCE CAUTION	Sequence=CAI20458.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW47705.1; Type=Erroneous initiation; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule	PRU00521}. 
# SUBCELLULAR LOCATION	OPRM_HUMAN	Cell membrane {ECO 0000269|PubMed 16580639}; Multi-pass membrane protein {ECO 0000269|PubMed 16580639}. 
# SUBCELLULAR LOCATION	OPRM_HUMAN	Isoform 12  Cytoplasm {ECO 0000269|PubMed 20525224}. 
# SUBUNIT	Forms homooligomers and heterooligomers with other GPCRs, such as OPRD1, OPRK1, OPRL1, NPFFR2, ADRA2A, SSTR2, CNR1 and CCR5 (probably in dimeric forms). Interacts with PPL; the interaction disrupts agonist-mediated G-protein activation. Interacts (via C- terminus) with DNAJB4 (via C-terminus). Interacts with calmodulin; the interaction inhibits the constitutive activity of OPRM1; it abolishes basal and attenuates agonist-stimulated G-protein coupling. Interacts with FLNA, PLD2, RANBP9 and WLS. Interacts with GPM6A, RTP4, SYP, GNAS, RGS9, RGS17, RGS20, RGS4, PPP1R9B and HINT1 (By similarity). {ECO	0000250}. 
# TCDB	9.A.14.13.18	the g-protein-coupled receptor (gpcr) family
# TISSUE SPECIFICITY	Expressed in brain. Isoform 16 and isoform 17 are detected in brain. {ECO:0000269|PubMed	16580639}. 
# UCSC	uc003qpn	human. [P35372-1]
# WEB RESOURCE	OPRM_HUMAN	Name=NIEHS-SNPs; URL="http //egp.gs.washington.edu/data/oprm1/";
# WEB RESOURCE	OPRM_HUMAN	Name=Wikipedia; Note=Mu opioid receptor entry; URL="https //en.wikipedia.org/wiki/Mu_opioid_receptor"; 
# eggNOG	ENOG410XRW9	LUCA
# eggNOG	KOG3656	Eukaryota
BLAST	swissprot:OPRM_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:OPRM_HUMAN
BioCyc	ZFISH:ENSG00000112038-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000112038-MONOMER
COXPRESdb	4988	http://coxpresdb.jp/data/gene/4988.shtml
CleanEx	HS_OPRM1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_OPRM1
DOI	10.1006/bbrc.1995.2709	http://dx.doi.org/10.1006/bbrc.1995.2709
DOI	10.1006/excr.2002.5638	http://dx.doi.org/10.1006/excr.2002.5638
DOI	10.1007/s00018-009-0008-4	http://dx.doi.org/10.1007/s00018-009-0008-4
DOI	10.1016/0014-5793(94)01129-X	http://dx.doi.org/10.1016/0014-5793(94)01129-X
DOI	10.1016/0014-5793(94)80368-4	http://dx.doi.org/10.1016/0014-5793(94)80368-4
DOI	10.1016/S0006-291X(03)00089-5	http://dx.doi.org/10.1016/S0006-291X(03)00089-5
DOI	10.1016/S0169-328X(99)00241-7	http://dx.doi.org/10.1016/S0169-328X(99)00241-7
DOI	10.1016/j.bbrc.2006.03.084	http://dx.doi.org/10.1016/j.bbrc.2006.03.084
DOI	10.1016/j.brainres.2006.01.125	http://dx.doi.org/10.1016/j.brainres.2006.01.125
DOI	10.1016/j.neulet.2009.09.048	http://dx.doi.org/10.1016/j.neulet.2009.09.048
DOI	10.1016/j.neuroscience.2004.12.033	http://dx.doi.org/10.1016/j.neuroscience.2004.12.033
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.mp.4000331	http://dx.doi.org/10.1038/sj.mp.4000331
DOI	10.1046/j.1471-4159.2000.0750763.x	http://dx.doi.org/10.1046/j.1471-4159.2000.0750763.x
DOI	10.1046/j.1471-4159.2002.00946.x	http://dx.doi.org/10.1046/j.1471-4159.2002.00946.x
DOI	10.1073/pnas.95.16.9608	http://dx.doi.org/10.1073/pnas.95.16.9608
DOI	10.1073/pnas.96.14.7752	http://dx.doi.org/10.1073/pnas.96.14.7752
DOI	10.1074/jbc.274.31.22081	http://dx.doi.org/10.1074/jbc.274.31.22081
DOI	10.1074/jbc.M206709200	http://dx.doi.org/10.1074/jbc.M206709200
DOI	10.1074/jbc.M305866200	http://dx.doi.org/10.1074/jbc.M305866200
DOI	10.1074/jbc.M606946200	http://dx.doi.org/10.1074/jbc.M606946200
DOI	10.1093/hmg/ddn439	http://dx.doi.org/10.1093/hmg/ddn439
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1471-4159.2008.05833.x	http://dx.doi.org/10.1111/j.1471-4159.2008.05833.x
DOI	10.1124/mol.104.010272	http://dx.doi.org/10.1124/mol.104.010272
DOI	10.1124/mol.105.013847	http://dx.doi.org/10.1124/mol.105.013847
DOI	10.1124/mol.64.5.1092	http://dx.doi.org/10.1124/mol.64.5.1092
DOI	10.1146/annurev.pharmtox.40.1.389	http://dx.doi.org/10.1146/annurev.pharmtox.40.1.389
DOI	10.1186/1471-2202-11-33	http://dx.doi.org/10.1186/1471-2202-11-33
DOI	10.1186/1744-8069-6-33	http://dx.doi.org/10.1186/1744-8069-6-33
DOI	10.4049/jimmunol.170.10.5118	http://dx.doi.org/10.4049/jimmunol.170.10.5118
DisProt	DP00272	http://www.disprot.org/protein.php?id=DP00272
DrugBank	DB00193	http://www.drugbank.ca/drugs/DB00193
DrugBank	DB00295	http://www.drugbank.ca/drugs/DB00295
DrugBank	DB00318	http://www.drugbank.ca/drugs/DB00318
DrugBank	DB00321	http://www.drugbank.ca/drugs/DB00321
DrugBank	DB00327	http://www.drugbank.ca/drugs/DB00327
DrugBank	DB00333	http://www.drugbank.ca/drugs/DB00333
DrugBank	DB00454	http://www.drugbank.ca/drugs/DB00454
DrugBank	DB00497	http://www.drugbank.ca/drugs/DB00497
DrugBank	DB00504	http://www.drugbank.ca/drugs/DB00504
DrugBank	DB00514	http://www.drugbank.ca/drugs/DB00514
DrugBank	DB00611	http://www.drugbank.ca/drugs/DB00611
DrugBank	DB00647	http://www.drugbank.ca/drugs/DB00647
DrugBank	DB00652	http://www.drugbank.ca/drugs/DB00652
DrugBank	DB00704	http://www.drugbank.ca/drugs/DB00704
DrugBank	DB00708	http://www.drugbank.ca/drugs/DB00708
DrugBank	DB00802	http://www.drugbank.ca/drugs/DB00802
DrugBank	DB00813	http://www.drugbank.ca/drugs/DB00813
DrugBank	DB00836	http://www.drugbank.ca/drugs/DB00836
DrugBank	DB00844	http://www.drugbank.ca/drugs/DB00844
DrugBank	DB00854	http://www.drugbank.ca/drugs/DB00854
DrugBank	DB00899	http://www.drugbank.ca/drugs/DB00899
DrugBank	DB00904	http://www.drugbank.ca/drugs/DB00904
DrugBank	DB00913	http://www.drugbank.ca/drugs/DB00913
DrugBank	DB00921	http://www.drugbank.ca/drugs/DB00921
DrugBank	DB00956	http://www.drugbank.ca/drugs/DB00956
DrugBank	DB01081	http://www.drugbank.ca/drugs/DB01081
DrugBank	DB01183	http://www.drugbank.ca/drugs/DB01183
DrugBank	DB01192	http://www.drugbank.ca/drugs/DB01192
DrugBank	DB01209	http://www.drugbank.ca/drugs/DB01209
DrugBank	DB01221	http://www.drugbank.ca/drugs/DB01221
DrugBank	DB01227	http://www.drugbank.ca/drugs/DB01227
DrugBank	DB01433	http://www.drugbank.ca/drugs/DB01433
DrugBank	DB01452	http://www.drugbank.ca/drugs/DB01452
DrugBank	DB01466	http://www.drugbank.ca/drugs/DB01466
DrugBank	DB06204	http://www.drugbank.ca/drugs/DB06204
DrugBank	DB06274	http://www.drugbank.ca/drugs/DB06274
DrugBank	DB06738	http://www.drugbank.ca/drugs/DB06738
DrugBank	DB06800	http://www.drugbank.ca/drugs/DB06800
DrugBank	DB09049	http://www.drugbank.ca/drugs/DB09049
DrugBank	DB09272	http://www.drugbank.ca/drugs/DB09272
EMBL	AF153500	http://www.ebi.ac.uk/ena/data/view/AF153500
EMBL	AK313901	http://www.ebi.ac.uk/ena/data/view/AK313901
EMBL	AL132774	http://www.ebi.ac.uk/ena/data/view/AL132774
EMBL	AL136444	http://www.ebi.ac.uk/ena/data/view/AL136444
EMBL	AL445220	http://www.ebi.ac.uk/ena/data/view/AL445220
EMBL	AY036622	http://www.ebi.ac.uk/ena/data/view/AY036622
EMBL	AY036623	http://www.ebi.ac.uk/ena/data/view/AY036623
EMBL	AY195733	http://www.ebi.ac.uk/ena/data/view/AY195733
EMBL	AY225404	http://www.ebi.ac.uk/ena/data/view/AY225404
EMBL	AY292290	http://www.ebi.ac.uk/ena/data/view/AY292290
EMBL	AY292291	http://www.ebi.ac.uk/ena/data/view/AY292291
EMBL	AY309001	http://www.ebi.ac.uk/ena/data/view/AY309001
EMBL	AY309005	http://www.ebi.ac.uk/ena/data/view/AY309005
EMBL	AY309006	http://www.ebi.ac.uk/ena/data/view/AY309006
EMBL	AY309007	http://www.ebi.ac.uk/ena/data/view/AY309007
EMBL	AY309008	http://www.ebi.ac.uk/ena/data/view/AY309008
EMBL	AY309009	http://www.ebi.ac.uk/ena/data/view/AY309009
EMBL	AY364230	http://www.ebi.ac.uk/ena/data/view/AY364230
EMBL	AY364890	http://www.ebi.ac.uk/ena/data/view/AY364890
EMBL	AY521028	http://www.ebi.ac.uk/ena/data/view/AY521028
EMBL	AY587764	http://www.ebi.ac.uk/ena/data/view/AY587764
EMBL	BC074927	http://www.ebi.ac.uk/ena/data/view/BC074927
EMBL	CH471051	http://www.ebi.ac.uk/ena/data/view/CH471051
EMBL	EU340241	http://www.ebi.ac.uk/ena/data/view/EU340241
EMBL	EU340242	http://www.ebi.ac.uk/ena/data/view/EU340242
EMBL	EU340243	http://www.ebi.ac.uk/ena/data/view/EU340243
EMBL	EU360599	http://www.ebi.ac.uk/ena/data/view/EU360599
EMBL	EU362990	http://www.ebi.ac.uk/ena/data/view/EU362990
EMBL	FJ041292	http://www.ebi.ac.uk/ena/data/view/FJ041292
EMBL	FJ041293	http://www.ebi.ac.uk/ena/data/view/FJ041293
EMBL	FJ041294	http://www.ebi.ac.uk/ena/data/view/FJ041294
EMBL	HQ699462	http://www.ebi.ac.uk/ena/data/view/HQ699462
EMBL	L25119	http://www.ebi.ac.uk/ena/data/view/L25119
EMBL	L29301	http://www.ebi.ac.uk/ena/data/view/L29301
EMBL	U12569	http://www.ebi.ac.uk/ena/data/view/U12569
Ensembl	ENST00000229768	http://www.ensembl.org/id/ENST00000229768
Ensembl	ENST00000330432	http://www.ensembl.org/id/ENST00000330432
Ensembl	ENST00000337049	http://www.ensembl.org/id/ENST00000337049
Ensembl	ENST00000414028	http://www.ensembl.org/id/ENST00000414028
Ensembl	ENST00000419506	http://www.ensembl.org/id/ENST00000419506
Ensembl	ENST00000428397	http://www.ensembl.org/id/ENST00000428397
Ensembl	ENST00000434900	http://www.ensembl.org/id/ENST00000434900
Ensembl	ENST00000435918	http://www.ensembl.org/id/ENST00000435918
Ensembl	ENST00000452687	http://www.ensembl.org/id/ENST00000452687
Ensembl	ENST00000518759	http://www.ensembl.org/id/ENST00000518759
Ensembl	ENST00000519083	http://www.ensembl.org/id/ENST00000519083
Ensembl	ENST00000520708	http://www.ensembl.org/id/ENST00000520708
Ensembl	ENST00000522236	http://www.ensembl.org/id/ENST00000522236
Ensembl	ENST00000522555	http://www.ensembl.org/id/ENST00000522555
Ensembl	ENST00000522739	http://www.ensembl.org/id/ENST00000522739
Ensembl	ENST00000524150	http://www.ensembl.org/id/ENST00000524150
Ensembl	ENST00000524163	http://www.ensembl.org/id/ENST00000524163
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005623	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005623
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005925	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005925
GO_component	GO:0032590	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032590
GO_component	GO:0032839	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032839
GO_component	GO:0042383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042383
GO_component	GO:0043005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043005
GO_component	GO:0043204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043204
GO_component	GO:0045121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045121
GO_component	GO:0098794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098794
GO_function	GO:0001965	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001965
GO_function	GO:0004930	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004930
GO_function	GO:0004979	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004979
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0031681	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031681
GO_function	GO:0038047	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0038047
GO_function	GO:0042923	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042923
GO_process	GO:0002438	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002438
GO_process	GO:0007187	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007187
GO_process	GO:0007191	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007191
GO_process	GO:0007194	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007194
GO_process	GO:0007200	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007200
GO_process	GO:0007204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007204
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007600	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007600
GO_process	GO:0007626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007626
GO_process	GO:0008285	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008285
GO_process	GO:0009314	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009314
GO_process	GO:0019233	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019233
GO_process	GO:0031635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031635
GO_process	GO:0032094	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032094
GO_process	GO:0032100	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032100
GO_process	GO:0032496	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032496
GO_process	GO:0033554	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033554
GO_process	GO:0042060	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042060
GO_process	GO:0042220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042220
GO_process	GO:0042755	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042755
GO_process	GO:0043950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043950
GO_process	GO:0043951	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043951
GO_process	GO:0044849	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044849
GO_process	GO:0045019	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045019
GO_process	GO:0045429	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045429
GO_process	GO:0048149	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048149
GO_process	GO:0050769	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050769
GO_process	GO:0051481	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051481
GO_process	GO:0051930	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051930
GO_process	GO:0060079	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060079
GO_process	GO:0061358	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061358
GO_process	GO:0070374	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070374
GO_process	GO:0070848	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070848
GO_process	GO:0071315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071315
GO_process	GO:2000310	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000310
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005623	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005623
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	OPRM1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=OPRM1
GeneID	4988	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4988
GeneTree	ENSGT00760000118797	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118797
HGNC	HGNC:8156	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:8156
HOGENOM	HOG000230486	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230486&db=HOGENOM6
HOVERGEN	HBG106919	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG106919&db=HOVERGEN
HPA	HPA014509	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014509
HPA	HPA067435	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA067435
InParanoid	P35372	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P35372
IntAct	P35372	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P35372*
InterPro	IPR000105	http://www.ebi.ac.uk/interpro/entry/IPR000105
InterPro	IPR000276	http://www.ebi.ac.uk/interpro/entry/IPR000276
InterPro	IPR001418	http://www.ebi.ac.uk/interpro/entry/IPR001418
InterPro	IPR017452	http://www.ebi.ac.uk/interpro/entry/IPR017452
Jabion	4988	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=4988
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04030	http://www.genome.jp/dbget-bin/www_bget?ko04030
KEGG_Disease	H01611	http://www.genome.jp/dbget-bin/www_bget?H01611
KEGG_Gene	hsa:4988	http://www.genome.jp/dbget-bin/www_bget?hsa:4988
KEGG_Orthology	KO:K04215	http://www.genome.jp/dbget-bin/www_bget?KO:K04215
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko05032	http://www.genome.jp/kegg-bin/show_pathway?ko05032
MIM	600018	http://www.ncbi.nlm.nih.gov/omim/600018
MINT	MINT-100121	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-100121
OMA	NSTRVRQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NSTRVRQ
OrthoDB	EOG091G0HEN	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0HEN
PRINTS	PR00237	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00237
PRINTS	PR00384	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00384
PRINTS	PR00537	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00537
PROSITE	PS00237	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00237
PROSITE	PS50262	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50262
PSORT	swissprot:OPRM_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:OPRM_HUMAN
PSORT-B	swissprot:OPRM_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:OPRM_HUMAN
PSORT2	swissprot:OPRM_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:OPRM_HUMAN
Pfam	PF00001	http://pfam.xfam.org/family/PF00001
PharmGKB	PA31945	http://www.pharmgkb.org/do/serve?objId=PA31945&objCls=Gene
Phobius	swissprot:OPRM_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:OPRM_HUMAN
PhylomeDB	P35372	http://phylomedb.org/?seqid=P35372
ProteinModelPortal	P35372	http://www.proteinmodelportal.org/query/uniprot/P35372
PubMed	10393893	http://www.ncbi.nlm.nih.gov/pubmed/10393893
PubMed	10419536	http://www.ncbi.nlm.nih.gov/pubmed/10419536
PubMed	10529478	http://www.ncbi.nlm.nih.gov/pubmed/10529478
PubMed	10836142	http://www.ncbi.nlm.nih.gov/pubmed/10836142
PubMed	10899953	http://www.ncbi.nlm.nih.gov/pubmed/10899953
PubMed	12068084	http://www.ncbi.nlm.nih.gov/pubmed/12068084
PubMed	12413885	http://www.ncbi.nlm.nih.gov/pubmed/12413885
PubMed	12519790	http://www.ncbi.nlm.nih.gov/pubmed/12519790
PubMed	12589820	http://www.ncbi.nlm.nih.gov/pubmed/12589820
PubMed	12734358	http://www.ncbi.nlm.nih.gov/pubmed/12734358
PubMed	12810704	http://www.ncbi.nlm.nih.gov/pubmed/12810704
PubMed	14573758	http://www.ncbi.nlm.nih.gov/pubmed/14573758
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15778451	http://www.ncbi.nlm.nih.gov/pubmed/15778451
PubMed	15893644	http://www.ncbi.nlm.nih.gov/pubmed/15893644
PubMed	15967873	http://www.ncbi.nlm.nih.gov/pubmed/15967873
PubMed	16542645	http://www.ncbi.nlm.nih.gov/pubmed/16542645
PubMed	16580639	http://www.ncbi.nlm.nih.gov/pubmed/16580639
PubMed	17224450	http://www.ncbi.nlm.nih.gov/pubmed/17224450
PubMed	19077058	http://www.ncbi.nlm.nih.gov/pubmed/19077058
PubMed	19103668	http://www.ncbi.nlm.nih.gov/pubmed/19103668
PubMed	19300905	http://www.ncbi.nlm.nih.gov/pubmed/19300905
PubMed	19788913	http://www.ncbi.nlm.nih.gov/pubmed/19788913
PubMed	20214800	http://www.ncbi.nlm.nih.gov/pubmed/20214800
PubMed	20525224	http://www.ncbi.nlm.nih.gov/pubmed/20525224
PubMed	7488213	http://www.ncbi.nlm.nih.gov/pubmed/7488213
PubMed	7891175	http://www.ncbi.nlm.nih.gov/pubmed/7891175
PubMed	7905839	http://www.ncbi.nlm.nih.gov/pubmed/7905839
PubMed	7957926	http://www.ncbi.nlm.nih.gov/pubmed/7957926
PubMed	9399694	http://www.ncbi.nlm.nih.gov/pubmed/9399694
PubMed	9689128	http://www.ncbi.nlm.nih.gov/pubmed/9689128
Reactome	R-HSA-111885	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-111885
Reactome	R-HSA-202040	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-202040
Reactome	R-HSA-375276	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-375276
Reactome	R-HSA-418594	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418594
RefSeq	NP_000905	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000905
RefSeq	NP_001008503	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001008503
RefSeq	NP_001008504	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001008504
RefSeq	NP_001008505	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001008505
RefSeq	NP_001138751	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001138751
RefSeq	NP_001138752	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001138752
RefSeq	NP_001138753	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001138753
RefSeq	NP_001138754	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001138754
RefSeq	NP_001138755	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001138755
RefSeq	NP_001138756	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001138756
RefSeq	NP_001138757	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001138757
RefSeq	NP_001138758	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001138758
RefSeq	NP_001138759	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001138759
RefSeq	NP_001272452	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001272452
RefSeq	NP_001272453	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001272453
RefSeq	NP_001272455	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001272455
RefSeq	NP_001272456	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001272456
RefSeq	NP_001272457	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001272457
RefSeq	XP_016866395	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016866395
SMR	P35372	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P35372
STRING	9606.ENSP00000394624	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000394624&targetmode=cogs
TCDB	9.A.14.13.18	http://www.tcdb.org/search/result.php?tc=9.A.14.13.18
UCSC	uc003qpn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003qpn&org=rat
UniGene	Hs.2353	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.2353
UniProtKB	OPRM_HUMAN	http://www.uniprot.org/uniprot/OPRM_HUMAN
UniProtKB-AC	P35372	http://www.uniprot.org/uniprot/P35372
charge	swissprot:OPRM_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:OPRM_HUMAN
eggNOG	ENOG410XRW9	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRW9
eggNOG	KOG3656	http://eggnogapi.embl.de/nog_data/html/tree/KOG3656
epestfind	swissprot:OPRM_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:OPRM_HUMAN
garnier	swissprot:OPRM_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:OPRM_HUMAN
helixturnhelix	swissprot:OPRM_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:OPRM_HUMAN
hmoment	swissprot:OPRM_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:OPRM_HUMAN
iep	swissprot:OPRM_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:OPRM_HUMAN
inforesidue	swissprot:OPRM_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:OPRM_HUMAN
neXtProt	NX_P35372	http://www.nextprot.org/db/entry/NX_P35372
octanol	swissprot:OPRM_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:OPRM_HUMAN
pepcoil	swissprot:OPRM_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:OPRM_HUMAN
pepdigest	swissprot:OPRM_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:OPRM_HUMAN
pepinfo	swissprot:OPRM_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:OPRM_HUMAN
pepnet	swissprot:OPRM_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:OPRM_HUMAN
pepstats	swissprot:OPRM_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:OPRM_HUMAN
pepwheel	swissprot:OPRM_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:OPRM_HUMAN
pepwindow	swissprot:OPRM_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:OPRM_HUMAN
sigcleave	swissprot:OPRM_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:OPRM_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	BASI_HUMAN	Event=Alternative promoter usage, Alternative splicing; Named isoforms=4; Name=1; Synonyms=Long, Basigin-2; IsoId=P35613-1; Sequence=Displayed; Name=2; Synonyms=Basigin-1; IsoId=P35613-2; Sequence=VSP_011501; Name=3; Synonyms=Basigin-3; IsoId=P35613-3; Sequence=VSP_043225; Note=Produced by alternative promoter usage. N-glycosylated.; Name=4; Synonyms=Basigin-4; IsoId=P35613-4; Sequence=VSP_043226, VSP_043227; Note=Produced by alternative promoter usage. N-glycosylated.; 
# AltName	BASI_HUMAN	5F7
# AltName	BASI_HUMAN	CD147
# AltName	BASI_HUMAN	Collagenase stimulatory factor
# AltName	BASI_HUMAN	Extracellular matrix metalloproteinase inducer
# AltName	BASI_HUMAN	Leukocyte activation antigen M6
# AltName	BASI_HUMAN	OK blood group antigen
# AltName	BASI_HUMAN	Tumor cell-derived collagenase stimulatory factor
# BioGrid	107147	142
# CCDS	CCDS12032	-. [P35613-4]
# CCDS	CCDS12033	-. [P35613-1]
# CCDS	CCDS12034	-. [P35613-2]
# CCDS	CCDS58635	-. [P35613-3]
# ChiTaRS	BSG	human
# Ensembl	ENST00000333511	ENSP00000333769; ENSG00000172270. [P35613-1]
# Ensembl	ENST00000346916	ENSP00000344707; ENSG00000172270. [P35613-4]
# Ensembl	ENST00000353555	ENSP00000343809; ENSG00000172270. [P35613-2]
# Ensembl	ENST00000545507	ENSP00000473664; ENSG00000172270. [P35613-3]
# ExpressionAtlas	P35613	baseline and differential
# FUNCTION	BASI_HUMAN	Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes. {ECO 0000269|PubMed 17127621}. 
# GO_component	GO:0000139	Golgi membrane; TAS:Reactome.
# GO_component	GO:0002080	acrosomal membrane; IEA:Ensembl.
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; ISS:UniProtKB.
# GO_component	GO:0005913	cell-cell adherens junction; IDA:BHF-UCL.
# GO_component	GO:0005925	focal adhesion; IDA:UniProtKB.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0042383	sarcolemma; IEA:Ensembl.
# GO_component	GO:0042470	melanosome; IEA:UniProtKB-SubCell.
# GO_component	GO:0045121	membrane raft; IEA:Ensembl.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005537	mannose binding; IEA:UniProtKB-KW.
# GO_function	GO:0008028	monocarboxylic acid transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0098641	cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
# GO_process	GO:0006090	pyruvate metabolic process; TAS:Reactome.
# GO_process	GO:0007166	cell surface receptor signaling pathway; TAS:ProtInc.
# GO_process	GO:0007566	embryo implantation; IEA:Ensembl.
# GO_process	GO:0022617	extracellular matrix disassembly; TAS:Reactome.
# GO_process	GO:0030198	extracellular matrix organization; TAS:Reactome.
# GO_process	GO:0042475	odontogenesis of dentin-containing tooth; IEA:Ensembl.
# GO_process	GO:0043434	response to peptide hormone; IEA:Ensembl.
# GO_process	GO:0046689	response to mercury ion; IEA:Ensembl.
# GO_process	GO:0046697	decidualization; IEA:Ensembl.
# GO_process	GO:0050900	leukocyte migration; TAS:Reactome.
# GO_process	GO:0051591	response to cAMP; IEA:Ensembl.
# GO_process	GO:0072661	protein targeting to plasma membrane; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006605	protein targeting
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0030198	extracellular matrix organization
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0048870	cell motility
# GOslim_process	GO:0061024	membrane organization
# Gene3D	2.60.40.10	-; 2.
# Genevisible	P35613	HS
# HGNC	HGNC:1116	BSG
# INDUCTION	BASI_HUMAN	Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with malignant potential of the tumor. 
# IntAct	P35613	32
# InterPro	IPR003598	Ig_sub2
# InterPro	IPR003599	Ig_sub
# InterPro	IPR007110	Ig-like_dom
# InterPro	IPR009151	Basigin
# InterPro	IPR013783	Ig-like_fold
# KEGG_Brite	ko04090	Cellular antigens
# MIM	109480	gene
# MIM	111380	phenotype
# Organism	BASI_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10075:SF12	PTHR10075:SF12
# PDB	3B5H	X-ray; 2.80 A; A/B/C/D=140-321
# PDB	3I84	X-ray; 2.00 A; A/B=13-219
# PDB	3I85	X-ray; 2.50 A; A/B=13-219
# PDB	3QQN	X-ray; 2.31 A; A/B=23-138
# PDB	3QR2	X-ray; 2.30 A; A/B=23-138
# PDB	4U0Q	X-ray; 3.10 A; B/D=1-385
# PIR	A46506	A46506
# PROSITE	PS50835	IG_LIKE; 3
# PTM	BASI_HUMAN	N-glycosylated. {ECO 0000269|PubMed 12754519, ECO 0000269|PubMed 19159218, ECO 0000269|PubMed 19349973}. 
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-1474228	Degradation of the extracellular matrix
# Reactome	R-HSA-210991	Basigin interactions
# Reactome	R-HSA-216083	Integrin cell surface interactions
# Reactome	R-HSA-433692	Proton-coupled monocarboxylate transport
# Reactome	R-HSA-70268	Pyruvate metabolism
# RecName	BASI_HUMAN	Basigin
# RefSeq	NP_001309172	NM_001322243.1. [P35613-2]
# RefSeq	NP_001719	NM_001728.3. [P35613-1]
# RefSeq	NP_940991	NM_198589.2. [P35613-2]
# RefSeq	NP_940992	NM_198590.2. [P35613-3]
# RefSeq	NP_940993	NM_198591.2. [P35613-4]
# RefSeq	XP_016882662	XM_017027173.1. [P35613-1]
# SIMILARITY	Contains 1 Ig-like C2-type (immunoglobulin-like) domain. {ECO	0000305}. 
# SIMILARITY	Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO	0000305}. 
# SMART	SM00408	IGc2; 2
# SMART	SM00409	IG; 2
# SUBCELLULAR LOCATION	BASI_HUMAN	Cell membrane {ECO 0000269|PubMed 15946952, ECO 0000269|PubMed 17127621, ECO 0000269|PubMed 21536654}; Single- pass type I membrane protein {ECO 0000303|PubMed 15946952}. Melanosome {ECO 0000269|PubMed 17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In spermatozoa, localized on the principal piece of caput and in the middle piece during transit in the corpus and cauda epididymides (By similarity). {ECO 0000250|UniProtKB P18572, ECO 0000269|PubMed 17081065}. 
# SUBUNIT	BASI_HUMAN	Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms heterooligomers of isoform 2 and isoform 3. Forms a complex with MMP1 at the tumor cell surface. Interacts with ATP1B2, MAG and L1CAM (By similarity). Interacts with AJAP1. Interacts with SLC16A1, SLC16A7 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with PPIL2; regulates BSG transport to the cell membrane. {ECO 0000250|UniProtKB P18572, ECO 0000250|UniProtKB P26453, ECO 0000269|PubMed 15946952, ECO 0000269|PubMed 17127621, ECO 0000269|PubMed 17267690, ECO 0000269|PubMed 18430721, ECO 0000269|PubMed 19768682, ECO 0000269|PubMed 21536654}. 
# SUPFAM	SSF48726	SSF48726; 3
# TCDB	8.A.23.1	the basigin (basigin) family
# TISSUE SPECIFICITY	BASI_HUMAN	Present only in vascular endothelium in non- neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas. 
# TopDownProteomics	P35613-1	-. [P35613-1]
# TopDownProteomics	P35613-2	-. [P35613-2]
# TopDownProteomics	P35613-3	-. [P35613-3]
# UCSC	uc002loy	human. [P35613-1]
# WEB RESOURCE	BASI_HUMAN	Name=SeattleSNPs; URL="http //pga.gs.washington.edu/data/bsg/";
# WEB RESOURCE	BASI_HUMAN	Name=dbRBC/BGMUT; Note=Blood group antigen gene mutation database; URL="https //www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=ok"; 
# eggNOG	ENOG410IJET	Eukaryota
# eggNOG	ENOG4111V1Q	LUCA
BLAST	swissprot:BASI_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:BASI_HUMAN
BioCyc	ZFISH:ENSG00000172270-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000172270-MONOMER
COXPRESdb	682	http://coxpresdb.jp/data/gene/682.shtml
CleanEx	HS_BSG	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_BSG
DIP	DIP-50310N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-50310N
DOI	10.1002/eji.1830270414	http://dx.doi.org/10.1002/eji.1830270414
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1002/prot.22577	http://dx.doi.org/10.1002/prot.22577
DOI	10.1016/0003-9861(91)90332-D	http://dx.doi.org/10.1016/0003-9861(91)90332-D
DOI	10.1016/S0378-1119(98)00400-4	http://dx.doi.org/10.1016/S0378-1119(98)00400-4
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr060363j	http://dx.doi.org/10.1021/pr060363j
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DOI	10.1038/nbt.1532	http://dx.doi.org/10.1038/nbt.1532
DOI	10.1038/nbt827	http://dx.doi.org/10.1038/nbt827
DOI	10.1074/jbc.M503770200	http://dx.doi.org/10.1074/jbc.M503770200
DOI	10.1074/jbc.M802694200	http://dx.doi.org/10.1074/jbc.M802694200
DOI	10.1080/09687860600841967	http://dx.doi.org/10.1080/09687860600841967
DOI	10.1091/mbc.E06-07-0637	http://dx.doi.org/10.1091/mbc.E06-07-0637
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1110/ps.04682504	http://dx.doi.org/10.1110/ps.04682504
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1128/MCB.05160-11	http://dx.doi.org/10.1128/MCB.05160-11
DOI	10.1167/iovs.02-0995	http://dx.doi.org/10.1167/iovs.02-0995
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AB072923	http://www.ebi.ac.uk/ena/data/view/AB072923
EMBL	AB085790	http://www.ebi.ac.uk/ena/data/view/AB085790
EMBL	AC005559	http://www.ebi.ac.uk/ena/data/view/AC005559
EMBL	AF042848	http://www.ebi.ac.uk/ena/data/view/AF042848
EMBL	AF042849	http://www.ebi.ac.uk/ena/data/view/AF042849
EMBL	AF042850	http://www.ebi.ac.uk/ena/data/view/AF042850
EMBL	AF042851	http://www.ebi.ac.uk/ena/data/view/AF042851
EMBL	AF042852	http://www.ebi.ac.uk/ena/data/view/AF042852
EMBL	AF042853	http://www.ebi.ac.uk/ena/data/view/AF042853
EMBL	AF042854	http://www.ebi.ac.uk/ena/data/view/AF042854
EMBL	AF548371	http://www.ebi.ac.uk/ena/data/view/AF548371
EMBL	AY358113	http://www.ebi.ac.uk/ena/data/view/AY358113
EMBL	AY942196	http://www.ebi.ac.uk/ena/data/view/AY942196
EMBL	BC009040	http://www.ebi.ac.uk/ena/data/view/BC009040
EMBL	CH471242	http://www.ebi.ac.uk/ena/data/view/CH471242
EMBL	CH471242	http://www.ebi.ac.uk/ena/data/view/CH471242
EMBL	D45131	http://www.ebi.ac.uk/ena/data/view/D45131
EMBL	GU557064	http://www.ebi.ac.uk/ena/data/view/GU557064
EMBL	GU557065	http://www.ebi.ac.uk/ena/data/view/GU557065
EMBL	L10240	http://www.ebi.ac.uk/ena/data/view/L10240
EMBL	L20471	http://www.ebi.ac.uk/ena/data/view/L20471
EMBL	M87879	http://www.ebi.ac.uk/ena/data/view/M87879
EMBL	X64364	http://www.ebi.ac.uk/ena/data/view/X64364
Ensembl	ENST00000333511	http://www.ensembl.org/id/ENST00000333511
Ensembl	ENST00000346916	http://www.ensembl.org/id/ENST00000346916
Ensembl	ENST00000353555	http://www.ensembl.org/id/ENST00000353555
Ensembl	ENST00000545507	http://www.ensembl.org/id/ENST00000545507
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0002080	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002080
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005913
GO_component	GO:0005925	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005925
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0042383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042383
GO_component	GO:0042470	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042470
GO_component	GO:0045121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045121
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005537	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005537
GO_function	GO:0008028	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008028
GO_function	GO:0098641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098641
GO_process	GO:0006090	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006090
GO_process	GO:0007166	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007166
GO_process	GO:0007566	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007566
GO_process	GO:0022617	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022617
GO_process	GO:0030198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030198
GO_process	GO:0042475	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042475
GO_process	GO:0043434	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043434
GO_process	GO:0046689	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046689
GO_process	GO:0046697	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046697
GO_process	GO:0050900	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050900
GO_process	GO:0051591	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051591
GO_process	GO:0072661	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072661
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0030198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030198
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
Gene3D	2.60.40.10	http://www.cathdb.info/version/latest/superfamily/2.60.40.10
GeneCards	BSG	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=BSG
GeneID	682	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=682
GeneTree	ENSGT00390000010516	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000010516
HGNC	HGNC:1116	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1116
HOGENOM	HOG000263411	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263411&db=HOGENOM6
HOVERGEN	HBG008120	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG008120&db=HOVERGEN
HPA	CAB002427	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB002427
HPA	HPA036048	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA036048
InParanoid	P35613	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P35613
IntAct	P35613	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P35613*
InterPro	IPR003598	http://www.ebi.ac.uk/interpro/entry/IPR003598
InterPro	IPR003599	http://www.ebi.ac.uk/interpro/entry/IPR003599
InterPro	IPR007110	http://www.ebi.ac.uk/interpro/entry/IPR007110
InterPro	IPR009151	http://www.ebi.ac.uk/interpro/entry/IPR009151
InterPro	IPR013783	http://www.ebi.ac.uk/interpro/entry/IPR013783
Jabion	682	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=682
KEGG_Brite	ko04090	http://www.genome.jp/dbget-bin/www_bget?ko04090
KEGG_Gene	hsa:682	http://www.genome.jp/dbget-bin/www_bget?hsa:682
KEGG_Orthology	KO:K06535	http://www.genome.jp/dbget-bin/www_bget?KO:K06535
MIM	109480	http://www.ncbi.nlm.nih.gov/omim/109480
MIM	111380	http://www.ncbi.nlm.nih.gov/omim/111380
MINT	MINT-5004205	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5004205
OMA	QANVFVI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QANVFVI
OrthoDB	EOG091G07LY	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07LY
PANTHER	PTHR10075:SF12	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10075:SF12
PDB	3B5H	http://www.ebi.ac.uk/pdbe-srv/view/entry/3B5H
PDB	3I84	http://www.ebi.ac.uk/pdbe-srv/view/entry/3I84
PDB	3I85	http://www.ebi.ac.uk/pdbe-srv/view/entry/3I85
PDB	3QQN	http://www.ebi.ac.uk/pdbe-srv/view/entry/3QQN
PDB	3QR2	http://www.ebi.ac.uk/pdbe-srv/view/entry/3QR2
PDB	4U0Q	http://www.ebi.ac.uk/pdbe-srv/view/entry/4U0Q
PDBsum	3B5H	http://www.ebi.ac.uk/pdbsum/3B5H
PDBsum	3I84	http://www.ebi.ac.uk/pdbsum/3I84
PDBsum	3I85	http://www.ebi.ac.uk/pdbsum/3I85
PDBsum	3QQN	http://www.ebi.ac.uk/pdbsum/3QQN
PDBsum	3QR2	http://www.ebi.ac.uk/pdbsum/3QR2
PDBsum	4U0Q	http://www.ebi.ac.uk/pdbsum/4U0Q
PROSITE	PS50835	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50835
PSORT	swissprot:BASI_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:BASI_HUMAN
PSORT-B	swissprot:BASI_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:BASI_HUMAN
PSORT2	swissprot:BASI_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:BASI_HUMAN
PharmGKB	PA25433	http://www.pharmgkb.org/do/serve?objId=PA25433&objCls=Gene
Phobius	swissprot:BASI_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:BASI_HUMAN
PhylomeDB	P35613	http://phylomedb.org/?seqid=P35613
ProteinModelPortal	P35613	http://www.proteinmodelportal.org/query/uniprot/P35613
PubMed	12754519	http://www.ncbi.nlm.nih.gov/pubmed/12754519
PubMed	12792908	http://www.ncbi.nlm.nih.gov/pubmed/12792908
PubMed	12939332	http://www.ncbi.nlm.nih.gov/pubmed/12939332
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	15340161	http://www.ncbi.nlm.nih.gov/pubmed/15340161
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15946952	http://www.ncbi.nlm.nih.gov/pubmed/15946952
PubMed	1634773	http://www.ncbi.nlm.nih.gov/pubmed/1634773
PubMed	17081065	http://www.ncbi.nlm.nih.gov/pubmed/17081065
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	17127621	http://www.ncbi.nlm.nih.gov/pubmed/17127621
PubMed	17267690	http://www.ncbi.nlm.nih.gov/pubmed/17267690
PubMed	1783610	http://www.ncbi.nlm.nih.gov/pubmed/1783610
PubMed	18430721	http://www.ncbi.nlm.nih.gov/pubmed/18430721
PubMed	1846736	http://www.ncbi.nlm.nih.gov/pubmed/1846736
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	19349973	http://www.ncbi.nlm.nih.gov/pubmed/19349973
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19768682	http://www.ncbi.nlm.nih.gov/pubmed/19768682
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	21536654	http://www.ncbi.nlm.nih.gov/pubmed/21536654
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	7812975	http://www.ncbi.nlm.nih.gov/pubmed/7812975
PubMed	9130641	http://www.ncbi.nlm.nih.gov/pubmed/9130641
PubMed	9767135	http://www.ncbi.nlm.nih.gov/pubmed/9767135
Reactome	R-HSA-1474228	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1474228
Reactome	R-HSA-210991	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-210991
Reactome	R-HSA-216083	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-216083
Reactome	R-HSA-433692	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-433692
Reactome	R-HSA-70268	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-70268
RefSeq	NP_001309172	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001309172
RefSeq	NP_001719	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001719
RefSeq	NP_940991	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_940991
RefSeq	NP_940992	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_940992
RefSeq	NP_940993	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_940993
RefSeq	XP_016882662	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016882662
SMART	SM00408	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00408
SMART	SM00409	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00409
SMR	P35613	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P35613
STRING	9606.ENSP00000333769	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000333769&targetmode=cogs
SUPFAM	SSF48726	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48726
TCDB	8.A.23.1	http://www.tcdb.org/search/result.php?tc=8.A.23.1
UCSC	uc002loy	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002loy&org=rat
UniGene	Hs.501293	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.501293
UniProtKB	BASI_HUMAN	http://www.uniprot.org/uniprot/BASI_HUMAN
UniProtKB-AC	P35613	http://www.uniprot.org/uniprot/P35613
charge	swissprot:BASI_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:BASI_HUMAN
eggNOG	ENOG410IJET	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IJET
eggNOG	ENOG4111V1Q	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111V1Q
epestfind	swissprot:BASI_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:BASI_HUMAN
garnier	swissprot:BASI_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:BASI_HUMAN
helixturnhelix	swissprot:BASI_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:BASI_HUMAN
hmoment	swissprot:BASI_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:BASI_HUMAN
iep	swissprot:BASI_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:BASI_HUMAN
inforesidue	swissprot:BASI_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:BASI_HUMAN
neXtProt	NX_P35613	http://www.nextprot.org/db/entry/NX_P35613
octanol	swissprot:BASI_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:BASI_HUMAN
pepcoil	swissprot:BASI_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:BASI_HUMAN
pepdigest	swissprot:BASI_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:BASI_HUMAN
pepinfo	swissprot:BASI_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:BASI_HUMAN
pepnet	swissprot:BASI_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:BASI_HUMAN
pepstats	swissprot:BASI_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:BASI_HUMAN
pepwheel	swissprot:BASI_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:BASI_HUMAN
pepwindow	swissprot:BASI_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:BASI_HUMAN
sigcleave	swissprot:BASI_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:BASI_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S38A6_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8IZM9-1; Sequence=Displayed; Name=2; IsoId=Q8IZM9-2; Sequence=VSP_029563; 
# AltName	S38A6_HUMAN	N-system amino acid transporter 1
# AltName	S38A6_HUMAN	Na(+)-coupled neutral amino acid transporter 6
# AltName	S38A6_HUMAN	Solute carrier family 38 member 6
# BioGrid	126909	9
# CCDS	CCDS53900	-. [Q8IZM9-2]
# CCDS	CCDS9751	-. [Q8IZM9-1]
# ChiTaRS	SLC38A6	human
# Ensembl	ENST00000267488	ENSP00000267488; ENSG00000139974. [Q8IZM9-1]
# Ensembl	ENST00000354886	ENSP00000346959; ENSG00000139974. [Q8IZM9-2]
# ExpressionAtlas	Q8IZM9	baseline and differential
# FUNCTION	S38A6_HUMAN	Probable sodium-dependent amino acid/proton antiporter, could be a neuronal transporter for glutamate. {ECO 0000250|UniProtKB G3UVW3}. 
# GO_component	GO:0005886	plasma membrane; ISS:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0003333	amino acid transmembrane transport; IBA:GO_Central.
# GO_process	GO:0006814	sodium ion transport; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q8IZM9	HS
# HGNC	HGNC:19863	SLC38A6
# InterPro	IPR013057	AA_transpt_TM
# KEGG_Brite	ko02001	Solute carrier family
# MIM	616518	gene
# Organism	S38A6_HUMAN	Homo sapiens (Human)
# Pfam	PF01490	Aa_trans
# Proteomes	UP000005640	Chromosome 14
# RecName	S38A6_HUMAN	Probable sodium-coupled neutral amino acid transporter 6
# RefSeq	NP_001166173	NM_001172702.1. [Q8IZM9-2]
# RefSeq	NP_722518	NM_153811.2. [Q8IZM9-1]
# SIMILARITY	Belongs to the amino acid/polyamine transporter 2 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S38A6_HUMAN	Cell membrane {ECO 0000250|UniProtKB G3UVW3}; Multi-pass membrane protein {ECO 0000255}. Note=Colocalizes with synaptotagmins and SNAP25. {ECO 0000250|UniProtKB G3UVW3}. 
# TCDB	2.A.18.6.11	the amino acid/auxin permease (aaap) family
# UCSC	uc001xfg	human. [Q8IZM9-1]
# eggNOG	COG0814	LUCA
# eggNOG	KOG1305	Eukaryota
BLAST	swissprot:S38A6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S38A6_HUMAN
COXPRESdb	145389	http://coxpresdb.jp/data/gene/145389.shtml
CleanEx	HS_NAT1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_NAT1
CleanEx	HS_SLC38A6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC38A6
DOI	10.1007/s00424-003-1117-9	http://dx.doi.org/10.1007/s00424-003-1117-9
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature01348	http://dx.doi.org/10.1038/nature01348
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
EMBL	AF543422	http://www.ebi.ac.uk/ena/data/view/AF543422
EMBL	AL160234	http://www.ebi.ac.uk/ena/data/view/AL160234
EMBL	AL160236	http://www.ebi.ac.uk/ena/data/view/AL160236
EMBL	BC110378	http://www.ebi.ac.uk/ena/data/view/BC110378
EMBL	BX248072	http://www.ebi.ac.uk/ena/data/view/BX248072
Ensembl	ENST00000267488	http://www.ensembl.org/id/ENST00000267488
Ensembl	ENST00000354886	http://www.ensembl.org/id/ENST00000354886
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_process	GO:0003333	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003333
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC38A6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC38A6
GeneID	145389	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=145389
GeneTree	ENSGT00760000119147	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119147
HGNC	HGNC:19863	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:19863
HOGENOM	HOG000013088	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000013088&db=HOGENOM6
HOVERGEN	HBG059571	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG059571&db=HOVERGEN
HPA	HPA018508	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA018508
InParanoid	Q8IZM9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8IZM9
InterPro	IPR013057	http://www.ebi.ac.uk/interpro/entry/IPR013057
Jabion	145389	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=145389
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:145389	http://www.genome.jp/dbget-bin/www_bget?hsa:145389
KEGG_Orthology	KO:K14993	http://www.genome.jp/dbget-bin/www_bget?KO:K14993
MIM	616518	http://www.ncbi.nlm.nih.gov/omim/616518
OMA	KRMQNAT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KRMQNAT
OrthoDB	EOG091G0GP8	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0GP8
PSORT	swissprot:S38A6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S38A6_HUMAN
PSORT-B	swissprot:S38A6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S38A6_HUMAN
PSORT2	swissprot:S38A6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S38A6_HUMAN
Pfam	PF01490	http://pfam.xfam.org/family/PF01490
PharmGKB	PA134932150	http://www.pharmgkb.org/do/serve?objId=PA134932150&objCls=Gene
Phobius	swissprot:S38A6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S38A6_HUMAN
PhylomeDB	Q8IZM9	http://phylomedb.org/?seqid=Q8IZM9
ProteinModelPortal	Q8IZM9	http://www.proteinmodelportal.org/query/uniprot/Q8IZM9
PubMed	12508121	http://www.ncbi.nlm.nih.gov/pubmed/12508121
PubMed	12845534	http://www.ncbi.nlm.nih.gov/pubmed/12845534
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
RefSeq	NP_001166173	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001166173
RefSeq	NP_722518	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_722518
STRING	9606.ENSP00000346959	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000346959&targetmode=cogs
TCDB	2.A.18.6.11	http://www.tcdb.org/search/result.php?tc=2.A.18.6.11
UCSC	uc001xfg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001xfg&org=rat
UniGene	Hs.200738	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.200738
UniProtKB	S38A6_HUMAN	http://www.uniprot.org/uniprot/S38A6_HUMAN
UniProtKB-AC	Q8IZM9	http://www.uniprot.org/uniprot/Q8IZM9
charge	swissprot:S38A6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S38A6_HUMAN
eggNOG	COG0814	http://eggnogapi.embl.de/nog_data/html/tree/COG0814
eggNOG	KOG1305	http://eggnogapi.embl.de/nog_data/html/tree/KOG1305
epestfind	swissprot:S38A6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S38A6_HUMAN
garnier	swissprot:S38A6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S38A6_HUMAN
helixturnhelix	swissprot:S38A6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S38A6_HUMAN
hmoment	swissprot:S38A6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S38A6_HUMAN
iep	swissprot:S38A6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S38A6_HUMAN
inforesidue	swissprot:S38A6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S38A6_HUMAN
neXtProt	NX_Q8IZM9	http://www.nextprot.org/db/entry/NX_Q8IZM9
octanol	swissprot:S38A6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S38A6_HUMAN
pepcoil	swissprot:S38A6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S38A6_HUMAN
pepdigest	swissprot:S38A6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S38A6_HUMAN
pepinfo	swissprot:S38A6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S38A6_HUMAN
pepnet	swissprot:S38A6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S38A6_HUMAN
pepstats	swissprot:S38A6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S38A6_HUMAN
pepwheel	swissprot:S38A6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S38A6_HUMAN
pepwindow	swissprot:S38A6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S38A6_HUMAN
sigcleave	swissprot:S38A6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S38A6_HUMAN
## Database	ID	URL or Descriptions
# AltName	SOAT_HUMAN	Sodium-dependent organic anion transporter
# Ensembl	ENST00000273905	ENSP00000273905; ENSG00000145283
# FUNCTION	SOAT_HUMAN	Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner. {ECO 0000269|PubMed 17491011}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0043250	sodium-dependent organic anion transmembrane transporter activity; IEA:Ensembl.
# GO_function	SOAT_HUMAN	GO 0008508 bile acid sodium symporter activity; IBA GO_Central.
# GO_process	GO:0043251	sodium-dependent organic anion transport; IEA:Ensembl.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# HGNC	HGNC:30603	SLC10A6
# InterPro	IPR002657:BilAc	Na_symport/Acr3
# InterPro	IPR004710:Bilac	Na_transpt
# InterPro	IPR030203	SLC10A6
# KEGG_Brite	ko02001	Solute carrier family
# MIM	613366	gene
# Organism	SOAT_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10361	PTHR10361
# PANTHER	PTHR10361:SF4	PTHR10361:SF4
# PTM	SOAT_HUMAN	Glycosylated. {ECO 0000269|PubMed 17491011}. 
# Pfam	PF01758	SBF
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-425366	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
# RecName	SOAT_HUMAN	Solute carrier family 10 member 6
# RefSeq	NP_932069	NM_197965.2
# SIMILARITY	Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	SOAT_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	2.A.28.1:the bile acid	na(+) symporter (bass) family
# TIGRFAMs	TIGR00841	bass
# TISSUE SPECIFICITY	Highly expressed in testis, placenta and pancreas. Moderately expressed in heart, lung and mammary gland. Weakly expressed in brain, colon, kidney, liver, ovary, prostate, small intestine, spleen and thymus. {ECO:0000269|PubMed	17491011}. 
# UCSC	uc003hqd	human
# eggNOG	COG0385	LUCA
# eggNOG	KOG2718	Eukaryota
BLAST	swissprot:SOAT_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SOAT_HUMAN
COXPRESdb	345274	http://coxpresdb.jp/data/gene/345274.shtml
CleanEx	HS_SLC10A6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC10A6
DOI	10.1074/jbc.M702663200	http://dx.doi.org/10.1074/jbc.M702663200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AJ583502	http://www.ebi.ac.uk/ena/data/view/AJ583502
EMBL	BC107051	http://www.ebi.ac.uk/ena/data/view/BC107051
EMBL	BC107052	http://www.ebi.ac.uk/ena/data/view/BC107052
EMBL	CH471057	http://www.ebi.ac.uk/ena/data/view/CH471057
EMBL	EF437223	http://www.ebi.ac.uk/ena/data/view/EF437223
Ensembl	ENST00000273905	http://www.ensembl.org/id/ENST00000273905
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0008508	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008508
GO_function	GO:0043250	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043250
GO_process	GO:0043251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043251
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC10A6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC10A6
GeneID	345274	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=345274
GeneTree	ENSGT00550000074505	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074505
HGNC	HGNC:30603	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:30603
HOGENOM	HOG000234524	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234524&db=HOGENOM6
HOVERGEN	HBG006537	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006537&db=HOVERGEN
HPA	HPA016662	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA016662
InParanoid	Q3KNW5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q3KNW5
InterPro	IPR002657	http://www.ebi.ac.uk/interpro/entry/IPR002657
InterPro	IPR004710	http://www.ebi.ac.uk/interpro/entry/IPR004710
InterPro	IPR030203	http://www.ebi.ac.uk/interpro/entry/IPR030203
Jabion	345274	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=345274
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:345274	http://www.genome.jp/dbget-bin/www_bget?hsa:345274
KEGG_Orthology	KO:K14346	http://www.genome.jp/dbget-bin/www_bget?KO:K14346
MIM	613366	http://www.ncbi.nlm.nih.gov/omim/613366
OMA	CLTIPVA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CLTIPVA
OrthoDB	EOG091G0GT5	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0GT5
PANTHER	PTHR10361	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10361
PANTHER	PTHR10361:SF4	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10361:SF4
PSORT	swissprot:SOAT_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SOAT_HUMAN
PSORT-B	swissprot:SOAT_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SOAT_HUMAN
PSORT2	swissprot:SOAT_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SOAT_HUMAN
Pfam	PF01758	http://pfam.xfam.org/family/PF01758
PharmGKB	PA142670910	http://www.pharmgkb.org/do/serve?objId=PA142670910&objCls=Gene
Phobius	swissprot:SOAT_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SOAT_HUMAN
PhylomeDB	Q3KNW5	http://phylomedb.org/?seqid=Q3KNW5
ProteinModelPortal	Q3KNW5	http://www.proteinmodelportal.org/query/uniprot/Q3KNW5
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17491011	http://www.ncbi.nlm.nih.gov/pubmed/17491011
Reactome	R-HSA-425366	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425366
RefSeq	NP_932069	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_932069
STRING	9606.ENSP00000273905	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000273905&targetmode=cogs
TCDB	2.A.28.1	http://www.tcdb.org/search/result.php?tc=2.A.28.1
TIGRFAMs	TIGR00841	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00841
UCSC	uc003hqd	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003hqd&org=rat
UniGene	Hs.452996	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.452996
UniProtKB	SOAT_HUMAN	http://www.uniprot.org/uniprot/SOAT_HUMAN
UniProtKB-AC	Q3KNW5	http://www.uniprot.org/uniprot/Q3KNW5
charge	swissprot:SOAT_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SOAT_HUMAN
eggNOG	COG0385	http://eggnogapi.embl.de/nog_data/html/tree/COG0385
eggNOG	KOG2718	http://eggnogapi.embl.de/nog_data/html/tree/KOG2718
epestfind	swissprot:SOAT_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SOAT_HUMAN
garnier	swissprot:SOAT_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SOAT_HUMAN
helixturnhelix	swissprot:SOAT_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SOAT_HUMAN
hmoment	swissprot:SOAT_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SOAT_HUMAN
iep	swissprot:SOAT_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SOAT_HUMAN
inforesidue	swissprot:SOAT_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SOAT_HUMAN
neXtProt	NX_Q3KNW5	http://www.nextprot.org/db/entry/NX_Q3KNW5
octanol	swissprot:SOAT_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SOAT_HUMAN
pepcoil	swissprot:SOAT_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SOAT_HUMAN
pepdigest	swissprot:SOAT_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SOAT_HUMAN
pepinfo	swissprot:SOAT_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SOAT_HUMAN
pepnet	swissprot:SOAT_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SOAT_HUMAN
pepstats	swissprot:SOAT_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SOAT_HUMAN
pepwheel	swissprot:SOAT_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SOAT_HUMAN
pepwindow	swissprot:SOAT_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SOAT_HUMAN
sigcleave	swissprot:SOAT_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SOAT_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S26A6_HUMAN	Event=Alternative splicing; Named isoforms=7; Name=1; Synonyms=SLC26A6b; IsoId=Q9BXS9-1; Sequence=Displayed; Name=2; IsoId=Q9BXS9-2; Sequence=VSP_006169; Note=No experimental confirmation available.; Name=3; IsoId=Q9BXS9-3; Sequence=VSP_040127; Name=4; Synonyms=SLC26A6a; IsoId=Q9BXS9-4; Sequence=VSP_046807, VSP_040127; Name=5; Synonyms=SLC26A6c; IsoId=Q9BXS9-5; Sequence=VSP_046807, VSP_047851, VSP_040127; Name=6; Synonyms=SLC26A6d; IsoId=Q9BXS9-6; Sequence=VSP_046807, VSP_047852; Name=7; IsoId=Q9BXS9-7; Sequence=VSP_055273, VSP_055274; Note=No experimental confirmation available.; 
# AltName	S26A6_HUMAN	Anion exchange transporter
# AltName	S26A6_HUMAN	Pendrin-like protein 1
# BioGrid	122373	17
# CCDS	CCDS43087	-. [Q9BXS9-1]
# CCDS	CCDS46824	-. [Q9BXS9-2]
# CCDS	CCDS46825	-. [Q9BXS9-3]
# CCDS	CCDS63628	-. [Q9BXS9-7]
# ENZYME REGULATION	S26A6_HUMAN	Apical membrane chloride-formate exchange activity in the proximal tubules of the kidney and oxalate secretion in the duodenum are inhibited by 4,4'- diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters) (By similarity). Apical membrane chloride-bicarbonate exchange activity of the pancreatic duct is inhibited by 4,4'-diisothiocyanatostilbene- 2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters). Isoform 4, isoform 5 and isoform 6 chloride, bicarbonate and sulfate transport activities are inhibited by DIDS. {ECO 0000250, ECO 0000269|PubMed 12444019, ECO 0000269|PubMed 15990874, ECO 0000269|PubMed 20501439}. 
# Ensembl	ENST00000383733	ENSP00000373239; ENSG00000225697. [Q9BXS9-2]
# Ensembl	ENST00000395550	ENSP00000378920; ENSG00000225697. [Q9BXS9-1]
# Ensembl	ENST00000420764	ENSP00000404684; ENSG00000225697. [Q9BXS9-3]
# Ensembl	ENST00000455886	ENSP00000401066; ENSG00000225697. [Q9BXS9-7]
# ExpressionAtlas	Q9BXS9	baseline and differential
# FUNCTION	S26A6_HUMAN	Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Function in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride- formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride- oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger provides also a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1 2, and hence will dilute and alkalinize protein-rich acinar secretion. Mediates also the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney. Plays a role in sperm capacitation by increasing intracellular pH. 
# FUNCTION	S26A6_HUMAN	Isoform 4  Apical membrane chloride-bicarbonate exchanger. Its association with carbonic anhydrase CA2 forms a bicarbonate transport metabolon; hence maximizes the local concentration of bicarbonate at the transporter site. 
# GO_component	GO:0005622	intracellular; IEA:GOC.
# GO_component	GO:0005783	endoplasmic reticulum; IEA:UniProtKB-KW.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0012506	vesicle membrane; ISS:UniProtKB.
# GO_component	GO:0016020	membrane; ISS:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IDA:UniProtKB.
# GO_component	GO:0016323	basolateral plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_component	GO:0030659	cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0031526	brush border membrane; IDA:UniProtKB.
# GO_component	GO:0031988	membrane-bounded vesicle; ISS:UniProtKB.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0097225	sperm midpiece; ISS:UniProtKB.
# GO_function	GO:0005254	chloride channel activity; IBA:GO_Central.
# GO_function	GO:0005452	inorganic anion exchanger activity; TAS:Reactome.
# GO_function	GO:0008271	secondary active sulfate transmembrane transporter activity; IEA:InterPro.
# GO_function	GO:0015106	bicarbonate transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015108	chloride transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015116	sulfate transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015499	formate transmembrane transporter activity; ISS:UniProtKB.
# GO_function	GO:0015562	efflux transmembrane transporter activity; ISS:UniProtKB.
# GO_function	GO:0015659	formate uptake transmembrane transporter activity; ISS:UniProtKB.
# GO_function	GO:0015660	formate efflux transmembrane transporter activity; ISS:UniProtKB.
# GO_function	GO:0019531	oxalate transmembrane transporter activity; IMP:UniProtKB.
# GO_function	GO:0030165	PDZ domain binding; ISS:UniProtKB.
# GO_function	S26A6_HUMAN	GO 0015301 anion anion antiporter activity; IDA UniProtKB.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006821	chloride transport; IDA:UniProtKB.
# GO_process	GO:0008272	sulfate transport; IMP:UniProtKB.
# GO_process	GO:0015701	bicarbonate transport; IDA:UniProtKB.
# GO_process	GO:0015724	formate transport; ISS:UniProtKB.
# GO_process	GO:0015797	mannitol transport; ISS:UniProtKB.
# GO_process	GO:0019532	oxalate transport; IMP:UniProtKB.
# GO_process	GO:0030321	transepithelial chloride transport; IMP:UniProtKB.
# GO_process	GO:0038166	angiotensin-activated signaling pathway; IDA:UniProtKB.
# GO_process	GO:0042045	epithelial fluid transport; ISS:UniProtKB.
# GO_process	GO:0042391	regulation of membrane potential; IBA:GO_Central.
# GO_process	GO:0046724	oxalic acid secretion; ISS:UniProtKB.
# GO_process	GO:0048240	sperm capacitation; ISS:UniProtKB.
# GO_process	GO:0050892	intestinal absorption; ISS:UniProtKB.
# GO_process	GO:0051453	regulation of intracellular pH; IDA:UniProtKB.
# GO_process	GO:0051454	intracellular pH elevation; ISS:UniProtKB.
# GO_process	GO:0070528	protein kinase C signaling; IDA:UniProtKB.
# GO_process	GO:0070633	transepithelial transport; ISS:UniProtKB.
# GO_process	GO:0071320	cellular response to cAMP; ISS:UniProtKB.
# GO_process	GO:0071332	cellular response to fructose stimulus; ISS:UniProtKB.
# GO_process	GO:0071346	cellular response to interferon-gamma; IDA:UniProtKB.
# GO_process	GO:2001150	positive regulation of dipeptide transmembrane transport; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005622	intracellular
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0021700	developmental maturation
# GOslim_process	GO:0042592	homeostatic process
# Gene3D	3.30.750.24	-; 2.
# Genevisible	Q9BXS9	HS
# HGNC	HGNC:14472	SLC26A6
# INDUCTION	Down-regulated by pro-inflammatory cytokine IFN gamma. {ECO:0000269|PubMed	18655181}. 
# InterPro	IPR001902	SLC26A/SulP_fam
# InterPro	IPR002645	STAS_dom
# InterPro	IPR011547	SLC26A/SulP_dom
# InterPro	IPR018045	S04_transporter_CS
# InterPro	IPR030323	SLC26A6
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04978	Mineral absorption
# MIM	610068	gene
# Organism	S26A6_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11814	PTHR11814; 2
# PANTHER	PTHR11814:SF113	PTHR11814:SF113; 2
# PROSITE	PS01130	SLC26A
# PROSITE	PS50801	STAS
# PTM	S26A6_HUMAN	Phosphorylated on serine residues by PKC; the phosphorylation disrupts interaction with carbonic anhydrase CA2 and reduces bicarbonate transport activity in a phorbol myristate acetate (PMA)-induced manner. {ECO 0000269|PubMed 15990874}. 
# Pfam	PF00916	Sulfate_transp
# Pfam	PF01740	STAS
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-427601	Multifunctional anion exchangers
# RecName	S26A6_HUMAN	Solute carrier family 26 member 6
# RefSeq	NP_001035544	NM_001040454.1
# RefSeq	NP_001268661	NM_001281732.1. [Q9BXS9-7]
# RefSeq	NP_001268662	NM_001281733.1
# RefSeq	NP_075062	NM_022911.2. [Q9BXS9-1]
# RefSeq	NP_599025	NM_134263.2. [Q9BXS9-3]
# RefSeq	NP_602298	NM_134426.2. [Q9BXS9-2]
# SIMILARITY	Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. {ECO	0000305}. 
# SIMILARITY	Contains 1 STAS domain. {ECO:0000255|PROSITE- ProRule	PRU00198}.
# SUBCELLULAR LOCATION	S26A6_HUMAN	Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Apical cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Cytoplasmic vesicle membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Microsome {ECO 0000250}. Note=Localized in sperm membranes. Colocalizes with CFTR at the midpiece of sperm tail. Localizes to the apical membrane brush border of epithelial cells in the proximal tubules of kidney, of enterocytes of the small intestine and of gastric parietal cells in the stomach. May be translocated from the cytosolic surface of the cell membrane to the intracellular space by PKC in phorbol myristate acetate (PMA)- induced cells (By similarity). Colocalized with CA2 at the surface of the cell membrane in order to form a bicarbonate transport metabolon; colocalization is reduced in phorbol myristate acetate (PMA)-induced cells. {ECO 0000250}. 
# SUBCELLULAR LOCATION	S26A6_HUMAN	Isoform 4  Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Localizes to the apical and basolateral surfaces of tubular wall cells in kidney and in the brush border of pancreatic duct cells. 
# SUBCELLULAR LOCATION	S26A6_HUMAN	Isoform 5  Cell membrane; Multi-pass membrane protein. 
# SUBCELLULAR LOCATION	S26A6_HUMAN	Isoform 6  Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	S26A6_HUMAN	Interacts (via C-terminal domain) with PDZK1 (via C- terminal PDZ domain); the interaction induces chloride and oxalate exchange transport. Interacts with CFTR, SLC26A3 and SLC9A3R1 (By similarity). Isoform 4 interacts (via C-terminal cytoplasmic domain) with CA2; the interaction stimulates chloride-bicarbonate exchange activity. Isoform 4 and isoform 5 interact with SLC9A3R1 (via the PDZ domains). Isoform 4 and isoform 5 interact with SLC9A3R2 (via the PDZ domains). Interacts with AHCYL1; the interaction increases SLC26A6 activity (By similarity). {ECO 0000250|UniProtKB Q9BXS9, ECO 0000269|PubMed 12444019, ECO 0000269|PubMed 15990874}. 
# SUPFAM	SSF52091	SSF52091; 2
# TCDB	2.A.53.2	the sulfate permease (sulp) family
# TIGRFAMs	TIGR00815	sulP
# TISSUE SPECIFICITY	S26A6_HUMAN	Ubiquitous. Highest levels in kidney and pancreas. Lower expression in heart, skeletal muscle, liver and placenta. Also found in lung and brain. Isoform 4 is ubiquitously expressed. Isoform 6 is expressed in heart, brain, placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis and ovary. Isoform 5 is expressed weakly in placenta, lung, liver and pancreas. {ECO 0000269|PubMed 11087667, ECO 0000269|PubMed 11247665}. 
# UCSC	uc003cug	human. [Q9BXS9-1]
# eggNOG	COG0659	LUCA
# eggNOG	KOG0236	Eukaryota
BLAST	swissprot:S26A6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S26A6_HUMAN
BioCyc	ZFISH:G66-32046-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32046-MONOMER
COXPRESdb	65010	http://coxpresdb.jp/data/gene/65010.shtml
CleanEx	HS_SLC26A6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC26A6
DOI	10.1002/jcb.21842	http://dx.doi.org/10.1002/jcb.21842
DOI	10.1006/geno.2000.6355	http://dx.doi.org/10.1006/geno.2000.6355
DOI	10.1006/geno.2000.6445	http://dx.doi.org/10.1006/geno.2000.6445
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.emboj.7600736	http://dx.doi.org/10.1038/sj.emboj.7600736
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1152/ajpcell.00270.2002	http://dx.doi.org/10.1152/ajpcell.00270.2002
DOI	10.1152/ajpgi.00251.2009	http://dx.doi.org/10.1152/ajpgi.00251.2009
DOI	10.1152/ajprenal.00079.2002	http://dx.doi.org/10.1152/ajprenal.00079.2002
EMBL	AB033288	http://www.ebi.ac.uk/ena/data/view/AB033288
EMBL	AC121252	http://www.ebi.ac.uk/ena/data/view/AC121252
EMBL	AF279265	http://www.ebi.ac.uk/ena/data/view/AF279265
EMBL	AF288410	http://www.ebi.ac.uk/ena/data/view/AF288410
EMBL	AF416721	http://www.ebi.ac.uk/ena/data/view/AF416721
EMBL	AK297695	http://www.ebi.ac.uk/ena/data/view/AK297695
EMBL	BC017697	http://www.ebi.ac.uk/ena/data/view/BC017697
EMBL	CH471055	http://www.ebi.ac.uk/ena/data/view/CH471055
EMBL	CH471055	http://www.ebi.ac.uk/ena/data/view/CH471055
Ensembl	ENST00000383733	http://www.ensembl.org/id/ENST00000383733
Ensembl	ENST00000395550	http://www.ensembl.org/id/ENST00000395550
Ensembl	ENST00000420764	http://www.ensembl.org/id/ENST00000420764
Ensembl	ENST00000455886	http://www.ensembl.org/id/ENST00000455886
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0012506	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0012506
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0030659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030659
GO_component	GO:0031526	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031526
GO_component	GO:0031988	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031988
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0097225	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097225
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0005452	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005452
GO_function	GO:0008271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008271
GO_function	GO:0015106	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015106
GO_function	GO:0015108	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015108
GO_function	GO:0015116	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015116
GO_function	GO:0015301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015301
GO_function	GO:0015499	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015499
GO_function	GO:0015562	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015562
GO_function	GO:0015659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015659
GO_function	GO:0015660	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015660
GO_function	GO:0019531	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019531
GO_function	GO:0030165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030165
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006821
GO_process	GO:0008272	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008272
GO_process	GO:0015701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015701
GO_process	GO:0015724	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015724
GO_process	GO:0015797	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015797
GO_process	GO:0019532	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019532
GO_process	GO:0030321	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030321
GO_process	GO:0038166	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0038166
GO_process	GO:0042045	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042045
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0046724	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046724
GO_process	GO:0048240	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048240
GO_process	GO:0050892	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050892
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GO_process	GO:0051454	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051454
GO_process	GO:0070528	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070528
GO_process	GO:0070633	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070633
GO_process	GO:0071320	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071320
GO_process	GO:0071332	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071332
GO_process	GO:0071346	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071346
GO_process	GO:2001150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001150
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0021700	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021700
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
Gene3D	3.30.750.24	http://www.cathdb.info/version/latest/superfamily/3.30.750.24
GeneCards	SLC26A6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC26A6
GeneID	65010	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=65010
GeneTree	ENSGT00760000119026	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119026
HGNC	HGNC:14472	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14472
HOGENOM	HOG000006546	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006546&db=HOGENOM6
HOVERGEN	HBG000639	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000639&db=HOVERGEN
HPA	HPA048363	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA048363
InParanoid	Q9BXS9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9BXS9
InterPro	IPR001902	http://www.ebi.ac.uk/interpro/entry/IPR001902
InterPro	IPR002645	http://www.ebi.ac.uk/interpro/entry/IPR002645
InterPro	IPR011547	http://www.ebi.ac.uk/interpro/entry/IPR011547
InterPro	IPR018045	http://www.ebi.ac.uk/interpro/entry/IPR018045
InterPro	IPR030323	http://www.ebi.ac.uk/interpro/entry/IPR030323
Jabion	65010	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=65010
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:65010	http://www.genome.jp/dbget-bin/www_bget?hsa:65010
KEGG_Orthology	KO:K14704	http://www.genome.jp/dbget-bin/www_bget?KO:K14704
KEGG_Pathway	ko04978	http://www.genome.jp/kegg-bin/show_pathway?ko04978
MIM	610068	http://www.ncbi.nlm.nih.gov/omim/610068
OMA	NNVEDCK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NNVEDCK
OrthoDB	EOG091G07RT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07RT
PANTHER	PTHR11814	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11814
PANTHER	PTHR11814:SF113	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11814:SF113
PROSITE	PS01130	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01130
PROSITE	PS50801	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50801
PSORT	swissprot:S26A6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S26A6_HUMAN
PSORT-B	swissprot:S26A6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S26A6_HUMAN
PSORT2	swissprot:S26A6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S26A6_HUMAN
Pfam	PF00916	http://pfam.xfam.org/family/PF00916
Pfam	PF01740	http://pfam.xfam.org/family/PF01740
PharmGKB	PA37889	http://www.pharmgkb.org/do/serve?objId=PA37889&objCls=Gene
Phobius	swissprot:S26A6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S26A6_HUMAN
PhylomeDB	Q9BXS9	http://phylomedb.org/?seqid=Q9BXS9
ProteinModelPortal	Q9BXS9	http://www.proteinmodelportal.org/query/uniprot/Q9BXS9
PubMed	11087667	http://www.ncbi.nlm.nih.gov/pubmed/11087667
PubMed	11247665	http://www.ncbi.nlm.nih.gov/pubmed/11247665
PubMed	12217875	http://www.ncbi.nlm.nih.gov/pubmed/12217875
PubMed	12444019	http://www.ncbi.nlm.nih.gov/pubmed/12444019
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15990874	http://www.ncbi.nlm.nih.gov/pubmed/15990874
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	18655181	http://www.ncbi.nlm.nih.gov/pubmed/18655181
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	20501439	http://www.ncbi.nlm.nih.gov/pubmed/20501439
Reactome	R-HSA-427601	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-427601
RefSeq	NP_001035544	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001035544
RefSeq	NP_001268661	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001268661
RefSeq	NP_001268662	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001268662
RefSeq	NP_075062	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_075062
RefSeq	NP_599025	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_599025
RefSeq	NP_602298	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_602298
STRING	9606.ENSP00000378920	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000378920&targetmode=cogs
SUPFAM	SSF52091	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52091
TCDB	2.A.53.2	http://www.tcdb.org/search/result.php?tc=2.A.53.2
TIGRFAMs	TIGR00815	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00815
UCSC	uc003cug	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003cug&org=rat
UniGene	Hs.631925	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.631925
UniGene	Hs.663208	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.663208
UniProtKB	S26A6_HUMAN	http://www.uniprot.org/uniprot/S26A6_HUMAN
UniProtKB-AC	Q9BXS9	http://www.uniprot.org/uniprot/Q9BXS9
charge	swissprot:S26A6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S26A6_HUMAN
eggNOG	COG0659	http://eggnogapi.embl.de/nog_data/html/tree/COG0659
eggNOG	KOG0236	http://eggnogapi.embl.de/nog_data/html/tree/KOG0236
epestfind	swissprot:S26A6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S26A6_HUMAN
garnier	swissprot:S26A6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S26A6_HUMAN
helixturnhelix	swissprot:S26A6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S26A6_HUMAN
hmoment	swissprot:S26A6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S26A6_HUMAN
iep	swissprot:S26A6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S26A6_HUMAN
inforesidue	swissprot:S26A6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S26A6_HUMAN
neXtProt	NX_Q9BXS9	http://www.nextprot.org/db/entry/NX_Q9BXS9
octanol	swissprot:S26A6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S26A6_HUMAN
pepcoil	swissprot:S26A6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S26A6_HUMAN
pepdigest	swissprot:S26A6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S26A6_HUMAN
pepinfo	swissprot:S26A6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S26A6_HUMAN
pepnet	swissprot:S26A6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S26A6_HUMAN
pepstats	swissprot:S26A6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S26A6_HUMAN
pepwheel	swissprot:S26A6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S26A6_HUMAN
pepwindow	swissprot:S26A6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S26A6_HUMAN
sigcleave	swissprot:S26A6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S26A6_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CAC1A_HUMAN	Event=Alternative splicing; Named isoforms=7; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=1A-1, BI-1-GGCAG; IsoId=O00555-1; Sequence=Displayed; Name=2; Synonyms=1A-2,BI-1; IsoId=O00555-2; Sequence=VSP_000875; Name=3; Synonyms=BI-1(V1); IsoId=O00555-3; Sequence=VSP_000871, VSP_000875; Name=4; Synonyms=BI-1(V1)-GGCAG; IsoId=O00555-4; Sequence=VSP_000871; Name=5; Synonyms=BI-1(V2); IsoId=O00555-5; Sequence=VSP_000872, VSP_000875; Name=6; Synonyms=BI-1(V2)-GGCAG; IsoId=O00555-6; Sequence=VSP_000872; Name=8; IsoId=O00555-8; Sequence=VSP_046165, VSP_046166; 
# AltName	CAC1A_HUMAN	Brain calcium channel I
# AltName	CAC1A_HUMAN	Calcium channel, L type, alpha-1 polypeptide isoform 4
# AltName	CAC1A_HUMAN	Voltage-gated calcium channel subunit alpha Cav2.1
# BioGrid	107227	98
# CCDS	CCDS45998	-. [O00555-8]
# CCDS	CCDS45999	-. [O00555-3]
# ChiTaRS	CACNA1A	human
# DISEASE	CAC1A_HUMAN	Episodic ataxia 2 (EA2) [MIM 108500]  An autosomal dominant disorder characterized by acetozolamide-responsive attacks of ataxia, migraine-like symptoms, interictal nystagmus, and cerebellar atrophy. {ECO 0000269|PubMed 10987655, ECO 0000269|PubMed 11176968, ECO 0000269|PubMed 11723274, ECO 0000269|PubMed 12420090, ECO 0000269|PubMed 14718690, ECO 0000269|PubMed 15173248, ECO 0000269|PubMed 15293273, ECO 0000269|PubMed 18602318, ECO 0000269|PubMed 19232643, ECO 0000269|PubMed 20129625, ECO 0000269|PubMed 21696515, ECO 0000269|PubMed 8898206, ECO 0000269|PubMed 9302278}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CAC1A_HUMAN	Migraine, familial hemiplegic, 1 (FHM1) [MIM 141500]  A subtype of migraine with aura associated with ictal hemiparesis and, in some families, cerebellar ataxia and atrophy. Migraine is a disabling symptom complex of periodic headaches, usually temporal and unilateral. Headaches are often accompanied by irritability, nausea, vomiting and photophobia, preceded by constriction of the cranial arteries. Migraine with aura is characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as blurred vision, hallucinations, vertigo, numbness and difficulty in concentrating and speaking. {ECO 0000269|PubMed 10408532, ECO 0000269|PubMed 11409427, ECO 0000269|PubMed 11439943, ECO 0000269|PubMed 15032980, ECO 0000269|PubMed 18400034, ECO 0000269|PubMed 8898206}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CAC1A_HUMAN	Spinocerebellar ataxia 6 (SCA6) [MIM 183086]  Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA6 is an autosomal dominant cerebellar ataxia (ADCA), mainly caused by expansion of a CAG repeat in the coding region of CACNA1A. There seems to be a correlation between the repeat number and earlier onset of the disorder. {ECO 0000269|PubMed 16325861, ECO 0000269|PubMed 20682717, ECO 0000269|PubMed 8988170, ECO 0000269|PubMed 9345107}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	CAC1A_HUMAN	Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position. 
# DrugBank	DB00230	Pregabalin
# DrugBank	DB00421	Spironolactone
# DrugBank	DB00661	Verapamil
# DrugBank	DB00836	Loperamide
# DrugBank	DB01244	Bepridil
# Ensembl	ENST00000360228	ENSP00000353362; ENSG00000141837. [O00555-8]
# Ensembl	ENST00000635895	ENSP00000490323; ENSG00000141837. [O00555-2]
# Ensembl	ENST00000637276	ENSP00000489777; ENSG00000141837. [O00555-5]
# Ensembl	ENST00000638009	ENSP00000489913; ENSG00000141837. [O00555-3]
# ExpressionAtlas	O00555	baseline and differential
# FUNCTION	CAC1A_HUMAN	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin- IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA). 
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005891	voltage-gated calcium channel complex; IEA:Ensembl.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0030425	dendrite; IEA:Ensembl.
# GO_component	GO:0042995	cell projection; IDA:UniProtKB.
# GO_component	GO:0043025	neuronal cell body; IEA:Ensembl.
# GO_component	GO:0098793	presynapse; IEA:GOC.
# GO_function	GO:0005245	voltage-gated calcium channel activity; IDA:UniProtKB.
# GO_function	GO:0005262	calcium channel activity; TAS:Reactome.
# GO_function	GO:0008331	high voltage-gated calcium channel activity; IBA:GO_Central.
# GO_function	GO:0019905	syntaxin binding; IDA:UniProtKB.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0000096	sulfur amino acid metabolic process; IEA:Ensembl.
# GO_process	GO:0006006	glucose metabolic process; IEA:Ensembl.
# GO_process	GO:0007204	positive regulation of cytosolic calcium ion concentration; IDA:UniProtKB.
# GO_process	GO:0007214	gamma-aminobutyric acid signaling pathway; IEA:Ensembl.
# GO_process	GO:0007274	neuromuscular synaptic transmission; IEA:Ensembl.
# GO_process	GO:0007416	synapse assembly; IEA:Ensembl.
# GO_process	GO:0007628	adult walking behavior; IEA:Ensembl.
# GO_process	GO:0008219	cell death; IDA:UniProtKB.
# GO_process	GO:0014051	gamma-aminobutyric acid secretion; IEA:Ensembl.
# GO_process	GO:0014056	regulation of acetylcholine secretion, neurotransmission; IEA:Ensembl.
# GO_process	GO:0016049	cell growth; IEA:Ensembl.
# GO_process	GO:0017158	regulation of calcium ion-dependent exocytosis; IEA:Ensembl.
# GO_process	GO:0019226	transmission of nerve impulse; IEA:Ensembl.
# GO_process	GO:0021522	spinal cord motor neuron differentiation; IEA:Ensembl.
# GO_process	GO:0021590	cerebellum maturation; IEA:Ensembl.
# GO_process	GO:0021679	cerebellar molecular layer development; IEA:Ensembl.
# GO_process	GO:0021702	cerebellar Purkinje cell differentiation; IEA:Ensembl.
# GO_process	GO:0021750	vestibular nucleus development; IEA:Ensembl.
# GO_process	GO:0030644	cellular chloride ion homeostasis; IEA:Ensembl.
# GO_process	GO:0032353	negative regulation of hormone biosynthetic process; IEA:Ensembl.
# GO_process	GO:0035249	synaptic transmission, glutamatergic; IEA:Ensembl.
# GO_process	GO:0042133	neurotransmitter metabolic process; IEA:Ensembl.
# GO_process	GO:0042445	hormone metabolic process; IEA:Ensembl.
# GO_process	GO:0043113	receptor clustering; IEA:Ensembl.
# GO_process	GO:0043524	negative regulation of neuron apoptotic process; IEA:Ensembl.
# GO_process	GO:0048266	behavioral response to pain; IEA:Ensembl.
# GO_process	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter; IEA:Ensembl.
# GO_process	GO:0048813	dendrite morphogenesis; IEA:Ensembl.
# GO_process	GO:0050770	regulation of axonogenesis; IEA:Ensembl.
# GO_process	GO:0050796	regulation of insulin secretion; TAS:Reactome.
# GO_process	GO:0050883	musculoskeletal movement, spinal reflex action; IEA:Ensembl.
# GO_process	GO:0050885	neuromuscular process controlling balance; IEA:Ensembl.
# GO_process	GO:0051899	membrane depolarization; TAS:Reactome.
# GO_process	GO:0060024	rhythmic synaptic transmission; IEA:Ensembl.
# GO_process	GO:0086010	membrane depolarization during action potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0005975	carbohydrate metabolic process
# GOslim_process	GO:0006520	cellular amino acid metabolic process
# GOslim_process	GO:0006790	sulfur compound metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0008219	cell death
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0021700	developmental maturation
# GOslim_process	GO:0022607	cellular component assembly
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0040007	growth
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0061024	membrane organization
# Gene3D	1.20.120.350	-; 4.
# Genevisible	O00555	HS
# HGNC	HGNC:1388	CACNA1A
# INTERACTION	CAC1A_HUMAN	Q8IZP0 ABI1; NbExp=2; IntAct=EBI-766279, EBI-375446; O94910 ADGRL1; NbExp=2; IntAct=EBI-766279, EBI-3389315; Q86SJ2 AMIGO2; NbExp=2; IntAct=EBI-766279, EBI-3866830; Q7Z5H3 ARHGAP22; NbExp=2; IntAct=EBI-766279, EBI-3866859; P67870 CSNK2B; NbExp=2; IntAct=EBI-766279, EBI-348169; O75953 DNAJB5; NbExp=2; IntAct=EBI-766279, EBI-5655937; P28799 GRN; NbExp=2; IntAct=EBI-766279, EBI-747754; P15822 HIVEP1; NbExp=2; IntAct=EBI-766279, EBI-722264; Q8N2S1 LTBP4; NbExp=2; IntAct=EBI-766279, EBI-947718; O00339 MATN2; NbExp=2; IntAct=EBI-766279, EBI-949020; O75095 MEGF6; NbExp=2; IntAct=EBI-766279, EBI-947597; Q7Z7M0 MEGF8; NbExp=2; IntAct=EBI-766279, EBI-947617; Q9UHX1 PUF60; NbExp=2; IntAct=EBI-766279, EBI-1053259; Q8IXT5 RBM12B; NbExp=2; IntAct=EBI-766279, EBI-3044077; O95153 TSPOAP1; NbExp=2; IntAct=EBI-766279, EBI-5915931; Q9BVA1 TUBB2B; NbExp=2; IntAct=EBI-766279, EBI-355665; P22695 UQCRC2; NbExp=2; IntAct=EBI-766279, EBI-1051424; P49750 YLPM1; NbExp=2; IntAct=EBI-766279, EBI-712871; 
# IntAct	O00555	92
# InterPro	IPR002077	VDCCAlpha1
# InterPro	IPR005448	CACNA1A
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR014873	VDCC_a1su_IQ
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR031649	GPHH_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00063	[Neurodegenerative disease] Spinocerebellar ataxia (SCA)
# KEGG_Disease	H00749	[Nervous system disease] Episodic ataxias
# KEGG_Disease	H00775	[Nervous system disease] Familial or sporadic hemiplegic migraine
# KEGG_Pathway	ko04010	MAPK signaling pathway
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04724	Glutamatergic synapse
# KEGG_Pathway	ko04725	Cholinergic synapse
# KEGG_Pathway	ko04726	Serotonergic synapse
# KEGG_Pathway	ko04727	GABAergic synapse
# KEGG_Pathway	ko04728	Dopaminergic synapse
# KEGG_Pathway	ko04730	Long-term depression
# KEGG_Pathway	ko04742	Taste transduction
# KEGG_Pathway	ko04930	Type II diabetes mellitus
# KEGG_Pathway	ko05032	Morphine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# MIM	108500	phenotype
# MIM	141500	phenotype
# MIM	183086	phenotype
# MIM	601011	gene
# Organism	CAC1A_HUMAN	Homo sapiens (Human)
# Orphanet	2131	Alternating hemiplegia of childhood
# Orphanet	569	Familial or sporadic hemiplegic migraine
# Orphanet	71518	Benign paroxysmal torticollis of infancy
# Orphanet	97	Familial paroxysmal ataxia
# Orphanet	98758	Spinocerebellar ataxia type 6
# PANTHER	PTHR10037:SF59	PTHR10037:SF59; 3
# PDB	3BXK	X-ray; 2.55 A; B/D=1955-1975
# POLYMORPHISM	The poly-Gln region of CACNA1A is polymorphic: 6 to 17 repeats in the normal population, expanded to about 21 to 30 repeats in SCA6. Repeat expansion has been reported also in a EA2 family. {ECO	0000269|PubMed:9302278}. 
# PRINTS	PR00167	CACHANNEL
# PRINTS	PR01632	PQVDCCALPHA1
# Pfam	PF00520	Ion_trans; 4
# Pfam	PF08763	Ca_chan_IQ
# Pfam	PF16905	GPHH
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-112308	Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
# Reactome	R-HSA-422356	Regulation of insulin secretion
# RecName	CAC1A_HUMAN	Voltage-dependent P/Q-type calcium channel subunit alpha-1A
# RefSeq	NP_000059	NM_000068.3
# RefSeq	NP_001120693	NM_001127221.1. [O00555-3]
# RefSeq	NP_001120694	NM_001127222.1. [O00555-8]
# RefSeq	NP_001167551	NM_001174080.1
# RefSeq	NP_075461	NM_023035.2
# SEQUENCE CAUTION	Sequence=AAB49678.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1A subfamily. {ECO	0000305}. 
# SMART	SM01062	Ca_chan_IQ
# SUBCELLULAR LOCATION	CAC1A_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1	1:1 ratio. The channel activity is directed by the pore- forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interact (via C-terminal CDB motif) with CABP1 in the pre- and postsynaptic membranes. 
# TCDB	1.A.1.11.27	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	Brain specific; mainly found in cerebellum, cerebral cortex, thalamus and hypothalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in heart, kidney, liver or muscle. Purkinje cells contain predominantly P- type VSCC, the Q-type being a prominent calcium current in cerebellar granule cells. {ECO:0000269|PubMed	1335101}. 
# UCSC	uc002mwy	human. [O00555-1]
# WEB RESOURCE	CAC1A_HUMAN	Name=Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (CACNA1A); Note=Leiden Open Variation Database (LOVD); URL="http //chromium.liacs.nl/LOVD2/home.php?select_db=CACNA1A"; 
# WEB RESOURCE	CAC1A_HUMAN	Name=Familial hemiplegic migraine (FHM) variation database, calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (CACNA1A); Note=Leiden Open Variation Database (LOVD); URL="http //grenada.lumc.nl/LOVD2/FHM/home.php?select_db=CACNA1A"; 
# WEB RESOURCE	CAC1A_HUMAN	Name=Undiagnosed Disease Network; Note=CACNA1A; URL="https //undiagnosed.hms.harvard.edu/updates/genes-of-interest/cacna1a-gene/";
# eggNOG	ENOG410XNP6	LUCA
# eggNOG	KOG2301	Eukaryota
BLAST	swissprot:CAC1A_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CAC1A_HUMAN
BioCyc	ZFISH:ENSG00000141837-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000141837-MONOMER
COXPRESdb	773	http://coxpresdb.jp/data/gene/773.shtml
DOI	10.1001/archneur.58.2.292	http://dx.doi.org/10.1001/archneur.58.2.292
DOI	10.1002/ana.1031	http://dx.doi.org/10.1002/ana.1031
DOI	10.1002/ana.20169	http://dx.doi.org/10.1002/ana.20169
DOI	10.1007/BF02255782	http://dx.doi.org/10.1007/BF02255782
DOI	10.1007/s00415-002-0860-8	http://dx.doi.org/10.1007/s00415-002-0860-8
DOI	10.1007/s004390051099	http://dx.doi.org/10.1007/s004390051099
DOI	10.1016/S0006-3495(99)77300-5	http://dx.doi.org/10.1016/S0006-3495(99)77300-5
DOI	10.1016/S0025-6196(12)61144-6	http://dx.doi.org/10.1016/S0025-6196(12)61144-6
DOI	10.1016/S0092-8674(00)81373-2	http://dx.doi.org/10.1016/S0092-8674(00)81373-2
DOI	10.1016/j.ejpn.2008.02.011	http://dx.doi.org/10.1016/j.ejpn.2008.02.011
DOI	10.1016/j.jns.2005.10.007	http://dx.doi.org/10.1016/j.jns.2005.10.007
DOI	10.1016/j.jns.2009.01.005	http://dx.doi.org/10.1016/j.jns.2009.01.005
DOI	10.1016/j.jns.2010.01.010	http://dx.doi.org/10.1016/j.jns.2010.01.010
DOI	10.1016/j.neulet.2009.01.081	http://dx.doi.org/10.1016/j.neulet.2009.01.081
DOI	10.1016/j.str.2008.01.011	http://dx.doi.org/10.1016/j.str.2008.01.011
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DOI	10.1038/ng0197-62	http://dx.doi.org/10.1038/ng0197-62
DOI	10.1038/nn805	http://dx.doi.org/10.1038/nn805
DOI	10.1056/NEJM200107053450103	http://dx.doi.org/10.1056/NEJM200107053450103
DOI	10.1074/jbc.275.15.10893	http://dx.doi.org/10.1074/jbc.275.15.10893
DOI	10.1086/301613	http://dx.doi.org/10.1086/301613
DOI	10.1093/hmg/6.11.1973	http://dx.doi.org/10.1093/hmg/6.11.1973
DOI	10.1111/j..2004.00187.x	http://dx.doi.org/10.1111/j..2004.00187.x
DOI	10.1111/j.1399-0004.2008.00996.x	http://dx.doi.org/10.1111/j.1399-0004.2008.00996.x
DOI	10.1111/j.1442-200X.2011.03390.x	http://dx.doi.org/10.1111/j.1442-200X.2011.03390.x
DOI	10.1111/j.1526-4610.2006.00504.x	http://dx.doi.org/10.1111/j.1526-4610.2006.00504.x
DOI	10.1136/jmg.2003.015396	http://dx.doi.org/10.1136/jmg.2003.015396
DOI	10.1136/jnnp.2008.163402	http://dx.doi.org/10.1136/jnnp.2008.163402
DOI	10.1212/01.WNL.0000101675.61074.50	http://dx.doi.org/10.1212/01.WNL.0000101675.61074.50
DOI	10.1212/WNL.53.1.26	http://dx.doi.org/10.1212/WNL.53.1.26
DOI	10.1212/WNL.57.10.1843	http://dx.doi.org/10.1212/WNL.57.10.1843
DrugBank	DB00230	http://www.drugbank.ca/drugs/DB00230
DrugBank	DB00421	http://www.drugbank.ca/drugs/DB00421
DrugBank	DB00661	http://www.drugbank.ca/drugs/DB00661
DrugBank	DB00836	http://www.drugbank.ca/drugs/DB00836
DrugBank	DB01244	http://www.drugbank.ca/drugs/DB01244
EMBL	AB035727	http://www.ebi.ac.uk/ena/data/view/AB035727
EMBL	AC005305	http://www.ebi.ac.uk/ena/data/view/AC005305
EMBL	AC005513	http://www.ebi.ac.uk/ena/data/view/AC005513
EMBL	AC008540	http://www.ebi.ac.uk/ena/data/view/AC008540
EMBL	AC011446	http://www.ebi.ac.uk/ena/data/view/AC011446
EMBL	AC022436	http://www.ebi.ac.uk/ena/data/view/AC022436
EMBL	AC026805	http://www.ebi.ac.uk/ena/data/view/AC026805
EMBL	AC093062	http://www.ebi.ac.uk/ena/data/view/AC093062
EMBL	AC098781	http://www.ebi.ac.uk/ena/data/view/AC098781
EMBL	AC124224	http://www.ebi.ac.uk/ena/data/view/AC124224
EMBL	AF004883	http://www.ebi.ac.uk/ena/data/view/AF004883
EMBL	AF004884	http://www.ebi.ac.uk/ena/data/view/AF004884
EMBL	S76537	http://www.ebi.ac.uk/ena/data/view/S76537
EMBL	U06702	http://www.ebi.ac.uk/ena/data/view/U06702
EMBL	U79663	http://www.ebi.ac.uk/ena/data/view/U79663
EMBL	U79664	http://www.ebi.ac.uk/ena/data/view/U79664
EMBL	U79665	http://www.ebi.ac.uk/ena/data/view/U79665
EMBL	U79666	http://www.ebi.ac.uk/ena/data/view/U79666
EMBL	U79667	http://www.ebi.ac.uk/ena/data/view/U79667
EMBL	U79668	http://www.ebi.ac.uk/ena/data/view/U79668
EMBL	X99897	http://www.ebi.ac.uk/ena/data/view/X99897
EMBL	Z80114	http://www.ebi.ac.uk/ena/data/view/Z80114
EMBL	Z80115	http://www.ebi.ac.uk/ena/data/view/Z80115
Ensembl	ENST00000360228	http://www.ensembl.org/id/ENST00000360228
Ensembl	ENST00000635895	http://www.ensembl.org/id/ENST00000635895
Ensembl	ENST00000637276	http://www.ensembl.org/id/ENST00000637276
Ensembl	ENST00000638009	http://www.ensembl.org/id/ENST00000638009
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005891
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0042995	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042995
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0098793	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098793
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0008331	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008331
GO_function	GO:0019905	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019905
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0000096	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000096
GO_process	GO:0006006	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006006
GO_process	GO:0007204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007204
GO_process	GO:0007214	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007214
GO_process	GO:0007274	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007274
GO_process	GO:0007416	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007416
GO_process	GO:0007628	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007628
GO_process	GO:0008219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219
GO_process	GO:0014051	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014051
GO_process	GO:0014056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014056
GO_process	GO:0016049	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016049
GO_process	GO:0017158	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017158
GO_process	GO:0019226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019226
GO_process	GO:0021522	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021522
GO_process	GO:0021590	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021590
GO_process	GO:0021679	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021679
GO_process	GO:0021702	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021702
GO_process	GO:0021750	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021750
GO_process	GO:0030644	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030644
GO_process	GO:0032353	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032353
GO_process	GO:0035249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035249
GO_process	GO:0042133	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042133
GO_process	GO:0042445	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042445
GO_process	GO:0043113	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043113
GO_process	GO:0043524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043524
GO_process	GO:0048266	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048266
GO_process	GO:0048791	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048791
GO_process	GO:0048813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048813
GO_process	GO:0050770	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050770
GO_process	GO:0050796	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050796
GO_process	GO:0050883	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050883
GO_process	GO:0050885	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050885
GO_process	GO:0051899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051899
GO_process	GO:0060024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060024
GO_process	GO:0086010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086010
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GOslim_process	GO:0006520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520
GOslim_process	GO:0006790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0008219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0021700	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021700
GOslim_process	GO:0022607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0040007	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040007
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	CACNA1A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CACNA1A
GeneID	773	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=773
GeneTree	ENSGT00830000128247	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00830000128247
HGNC	HGNC:1388	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1388
HOGENOM	HOG000231530	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231530&db=HOGENOM6
HOVERGEN	HBG050763	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050763&db=HOVERGEN
HPA	HPA064258	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA064258
InParanoid	O00555	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O00555
IntAct	O00555	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O00555*
InterPro	IPR002077	http://www.ebi.ac.uk/interpro/entry/IPR002077
InterPro	IPR005448	http://www.ebi.ac.uk/interpro/entry/IPR005448
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR014873	http://www.ebi.ac.uk/interpro/entry/IPR014873
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR031649	http://www.ebi.ac.uk/interpro/entry/IPR031649
Jabion	773	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=773
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00063	http://www.genome.jp/dbget-bin/www_bget?H00063
KEGG_Disease	H00749	http://www.genome.jp/dbget-bin/www_bget?H00749
KEGG_Disease	H00775	http://www.genome.jp/dbget-bin/www_bget?H00775
KEGG_Gene	hsa:773	http://www.genome.jp/dbget-bin/www_bget?hsa:773
KEGG_Orthology	KO:K04344	http://www.genome.jp/dbget-bin/www_bget?KO:K04344
KEGG_Pathway	ko04010	http://www.genome.jp/kegg-bin/show_pathway?ko04010
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
KEGG_Pathway	ko04725	http://www.genome.jp/kegg-bin/show_pathway?ko04725
KEGG_Pathway	ko04726	http://www.genome.jp/kegg-bin/show_pathway?ko04726
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
KEGG_Pathway	ko04728	http://www.genome.jp/kegg-bin/show_pathway?ko04728
KEGG_Pathway	ko04730	http://www.genome.jp/kegg-bin/show_pathway?ko04730
KEGG_Pathway	ko04742	http://www.genome.jp/kegg-bin/show_pathway?ko04742
KEGG_Pathway	ko04930	http://www.genome.jp/kegg-bin/show_pathway?ko04930
KEGG_Pathway	ko05032	http://www.genome.jp/kegg-bin/show_pathway?ko05032
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
MIM	108500	http://www.ncbi.nlm.nih.gov/omim/108500
MIM	141500	http://www.ncbi.nlm.nih.gov/omim/141500
MIM	183086	http://www.ncbi.nlm.nih.gov/omim/183086
MIM	601011	http://www.ncbi.nlm.nih.gov/omim/601011
Orphanet	2131	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=2131
Orphanet	569	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=569
Orphanet	71518	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=71518
Orphanet	97	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=97
Orphanet	98758	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98758
PANTHER	PTHR10037:SF59	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10037:SF59
PDB	3BXK	http://www.ebi.ac.uk/pdbe-srv/view/entry/3BXK
PDBsum	3BXK	http://www.ebi.ac.uk/pdbsum/3BXK
PRINTS	PR00167	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00167
PRINTS	PR01632	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01632
PSORT	swissprot:CAC1A_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CAC1A_HUMAN
PSORT-B	swissprot:CAC1A_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CAC1A_HUMAN
PSORT2	swissprot:CAC1A_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CAC1A_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF08763	http://pfam.xfam.org/family/PF08763
Pfam	PF16905	http://pfam.xfam.org/family/PF16905
PharmGKB	PA26007	http://www.pharmgkb.org/do/serve?objId=PA26007&objCls=Gene
Phobius	swissprot:CAC1A_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CAC1A_HUMAN
PhylomeDB	O00555	http://phylomedb.org/?seqid=O00555
ProteinModelPortal	O00555	http://www.proteinmodelportal.org/query/uniprot/O00555
PubMed	10049321	http://www.ncbi.nlm.nih.gov/pubmed/10049321
PubMed	10408532	http://www.ncbi.nlm.nih.gov/pubmed/10408532
PubMed	10753886	http://www.ncbi.nlm.nih.gov/pubmed/10753886
PubMed	10987655	http://www.ncbi.nlm.nih.gov/pubmed/10987655
PubMed	11176968	http://www.ncbi.nlm.nih.gov/pubmed/11176968
PubMed	11409427	http://www.ncbi.nlm.nih.gov/pubmed/11409427
PubMed	11439943	http://www.ncbi.nlm.nih.gov/pubmed/11439943
PubMed	11723274	http://www.ncbi.nlm.nih.gov/pubmed/11723274
PubMed	11865310	http://www.ncbi.nlm.nih.gov/pubmed/11865310
PubMed	12420090	http://www.ncbi.nlm.nih.gov/pubmed/12420090
PubMed	1335101	http://www.ncbi.nlm.nih.gov/pubmed/1335101
PubMed	14718690	http://www.ncbi.nlm.nih.gov/pubmed/14718690
PubMed	15032980	http://www.ncbi.nlm.nih.gov/pubmed/15032980
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	15173248	http://www.ncbi.nlm.nih.gov/pubmed/15173248
PubMed	15293273	http://www.ncbi.nlm.nih.gov/pubmed/15293273
PubMed	16325861	http://www.ncbi.nlm.nih.gov/pubmed/16325861
PubMed	16866717	http://www.ncbi.nlm.nih.gov/pubmed/16866717
PubMed	18400034	http://www.ncbi.nlm.nih.gov/pubmed/18400034
PubMed	18400181	http://www.ncbi.nlm.nih.gov/pubmed/18400181
PubMed	18602318	http://www.ncbi.nlm.nih.gov/pubmed/18602318
PubMed	19232643	http://www.ncbi.nlm.nih.gov/pubmed/19232643
PubMed	19429006	http://www.ncbi.nlm.nih.gov/pubmed/19429006
PubMed	20129625	http://www.ncbi.nlm.nih.gov/pubmed/20129625
PubMed	20682717	http://www.ncbi.nlm.nih.gov/pubmed/20682717
PubMed	21696515	http://www.ncbi.nlm.nih.gov/pubmed/21696515
PubMed	7823133	http://www.ncbi.nlm.nih.gov/pubmed/7823133
PubMed	8525433	http://www.ncbi.nlm.nih.gov/pubmed/8525433
PubMed	8898206	http://www.ncbi.nlm.nih.gov/pubmed/8898206
PubMed	8988170	http://www.ncbi.nlm.nih.gov/pubmed/8988170
PubMed	9302278	http://www.ncbi.nlm.nih.gov/pubmed/9302278
PubMed	9345107	http://www.ncbi.nlm.nih.gov/pubmed/9345107
Reactome	R-HSA-112308	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112308
Reactome	R-HSA-422356	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-422356
RefSeq	NP_000059	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000059
RefSeq	NP_001120693	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001120693
RefSeq	NP_001120694	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001120694
RefSeq	NP_001167551	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001167551
RefSeq	NP_075461	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_075461
SMART	SM01062	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01062
SMR	O00555	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O00555
STRING	9606.ENSP00000353362	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000353362&targetmode=cogs
TCDB	1.A.1.11.27	http://www.tcdb.org/search/result.php?tc=1.A.1.11.27
UCSC	uc002mwy	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002mwy&org=rat
UniGene	Hs.501632	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.501632
UniProtKB	CAC1A_HUMAN	http://www.uniprot.org/uniprot/CAC1A_HUMAN
UniProtKB-AC	O00555	http://www.uniprot.org/uniprot/O00555
charge	swissprot:CAC1A_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CAC1A_HUMAN
eggNOG	ENOG410XNP6	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNP6
eggNOG	KOG2301	http://eggnogapi.embl.de/nog_data/html/tree/KOG2301
epestfind	swissprot:CAC1A_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CAC1A_HUMAN
garnier	swissprot:CAC1A_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CAC1A_HUMAN
helixturnhelix	swissprot:CAC1A_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CAC1A_HUMAN
hmoment	swissprot:CAC1A_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CAC1A_HUMAN
iep	swissprot:CAC1A_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CAC1A_HUMAN
inforesidue	swissprot:CAC1A_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CAC1A_HUMAN
neXtProt	NX_O00555	http://www.nextprot.org/db/entry/NX_O00555
octanol	swissprot:CAC1A_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CAC1A_HUMAN
pepcoil	swissprot:CAC1A_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CAC1A_HUMAN
pepdigest	swissprot:CAC1A_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CAC1A_HUMAN
pepinfo	swissprot:CAC1A_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CAC1A_HUMAN
pepnet	swissprot:CAC1A_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CAC1A_HUMAN
pepstats	swissprot:CAC1A_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CAC1A_HUMAN
pepwheel	swissprot:CAC1A_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CAC1A_HUMAN
pepwindow	swissprot:CAC1A_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CAC1A_HUMAN
sigcleave	swissprot:CAC1A_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CAC1A_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CLIC6_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=B; IsoId=Q96NY7-1; Sequence=Displayed; Name=A; IsoId=Q96NY7-2; Sequence=VSP_008963; 
# AltName	CLIC6_HUMAN	Parchorin
# BioGrid	119900	4
# CCDS	CCDS13638	-. [Q96NY7-2]
# CCDS	CCDS82669	-. [Q96NY7-1]
# ChiTaRS	CLIC6	human
# DOMAIN	CLIC6_HUMAN	Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity). {ECO 0000250}. 
# Ensembl	ENST00000349499	ENSP00000290332; ENSG00000159212. [Q96NY7-2]
# Ensembl	ENST00000360731	ENSP00000353959; ENSG00000159212. [Q96NY7-1]
# FUNCTION	CLIC6_HUMAN	May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity). {ECO 0000250}. 
# GO_component	GO:0005737	cytoplasm; IBA:GO_Central.
# GO_component	GO:0005886	plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005244	voltage-gated ion channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0005254	chloride channel activity; IBA:GO_Central.
# GO_process	GO:1902476	chloride transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.1050.10	-; 1.
# Gene3D	3.40.30.10	-; 1.
# Genevisible	Q96NY7	HS
# HGNC	HGNC:2065	CLIC6
# InterPro	IPR002946	CLIC
# InterPro	IPR010987	Glutathione-S-Trfase_C-like
# InterPro	IPR012336	Thioredoxin-like_fold
# InterPro	IPR030263	CLIC-6
# KEGG_Brite	ko04040	Ion channels
# MIM	615321	gene
# Organism	CLIC6_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11260:SF142	PTHR11260:SF142; 3
# PRINTS	PR01263	INTCLCHANNEL
# PROSITE	PS50405	GST_CTER
# PTM	CLIC6_HUMAN	Phosphorylated. {ECO 0000250}. 
# Proteomes	UP000005640	Chromosome 21
# RecName	CLIC6_HUMAN	Chloride intracellular channel protein 6
# RefSeq	NP_001303938	NM_001317009.1. [Q96NY7-1]
# RefSeq	NP_444507	NM_053277.2. [Q96NY7-2]
# SEQUENCE CAUTION	Sequence=BAC03959.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the chloride channel CLIC family. {ECO	0000305}. 
# SIMILARITY	Contains 1 GST C-terminal domain. {ECO	0000305}. 
# SUBCELLULAR LOCATION	CLIC6_HUMAN	Cytoplasm {ECO 0000250}. Cell membrane {ECO 0000250}; Single-pass membrane protein {ECO 0000250}. Note=Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane (By similarity). {ECO 0000250}. 
# SUBUNIT	Interacts with dopamine receptors DRD2, DRD3 and DRD4. {ECO	0000250}. 
# SUPFAM	SSF47616	SSF47616
# SUPFAM	SSF52833	SSF52833
# TCDB	1.A.12.1	the intracellular chloride channel (clic) family
# TIGRFAMs	TIGR00862	O-ClC
# TISSUE SPECIFICITY	Expressed in brain, placenta, pancreas and liver. {ECO:0000269|PubMed	12226712}. 
# UCSC	uc002yuf	human. [Q96NY7-1]
# eggNOG	ENOG410ZRK6	LUCA
# eggNOG	KOG1422	Eukaryota
BLAST	swissprot:CLIC6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CLIC6_HUMAN
BioCyc	ZFISH:ENSG00000159212-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000159212-MONOMER
COXPRESdb	54102	http://coxpresdb.jp/data/gene/54102.shtml
CleanEx	HS_CLIC6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CLIC6
DOI	10.1007/s00335-001-2157-0	http://dx.doi.org/10.1007/s00335-001-2157-0
DOI	10.1016/S0378-1119(03)00830-8	http://dx.doi.org/10.1016/S0378-1119(03)00830-8
DOI	10.1038/35012518	http://dx.doi.org/10.1038/35012518
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF426169	http://www.ebi.ac.uk/ena/data/view/AF426169
EMBL	AF448438	http://www.ebi.ac.uk/ena/data/view/AF448438
EMBL	AF448439	http://www.ebi.ac.uk/ena/data/view/AF448439
EMBL	AK092733	http://www.ebi.ac.uk/ena/data/view/AK092733
EMBL	AK289663	http://www.ebi.ac.uk/ena/data/view/AK289663
EMBL	AP001720	http://www.ebi.ac.uk/ena/data/view/AP001720
EMBL	BC040196	http://www.ebi.ac.uk/ena/data/view/BC040196
EMBL	CH471079	http://www.ebi.ac.uk/ena/data/view/CH471079
Ensembl	ENST00000349499	http://www.ensembl.org/id/ENST00000349499
Ensembl	ENST00000360731	http://www.ensembl.org/id/ENST00000360731
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005244
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.1050.10	http://www.cathdb.info/version/latest/superfamily/1.20.1050.10
Gene3D	3.40.30.10	http://www.cathdb.info/version/latest/superfamily/3.40.30.10
GeneCards	CLIC6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CLIC6
GeneID	54102	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54102
GeneTree	ENSGT00550000074477	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074477
H-InvDB	HIX0016092	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0016092
HGNC	HGNC:2065	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2065
HOGENOM	HOG000013008	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000013008&db=HOGENOM6
HOVERGEN	HBG050996	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050996&db=HOVERGEN
HPA	HPA055123	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA055123
HPA	HPA065285	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA065285
InParanoid	Q96NY7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96NY7
InterPro	IPR002946	http://www.ebi.ac.uk/interpro/entry/IPR002946
InterPro	IPR010987	http://www.ebi.ac.uk/interpro/entry/IPR010987
InterPro	IPR012336	http://www.ebi.ac.uk/interpro/entry/IPR012336
InterPro	IPR030263	http://www.ebi.ac.uk/interpro/entry/IPR030263
Jabion	54102	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=54102
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:54102	http://www.genome.jp/dbget-bin/www_bget?hsa:54102
KEGG_Orthology	KO:K05026	http://www.genome.jp/dbget-bin/www_bget?KO:K05026
MIM	615321	http://www.ncbi.nlm.nih.gov/omim/615321
OMA	PGQEHDI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PGQEHDI
OrthoDB	EOG091G0IHT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0IHT
PANTHER	PTHR11260:SF142	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11260:SF142
PRINTS	PR01263	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01263
PROSITE	PS50405	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50405
PSORT	swissprot:CLIC6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CLIC6_HUMAN
PSORT-B	swissprot:CLIC6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CLIC6_HUMAN
PSORT2	swissprot:CLIC6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CLIC6_HUMAN
PharmGKB	PA26593	http://www.pharmgkb.org/do/serve?objId=PA26593&objCls=Gene
Phobius	swissprot:CLIC6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CLIC6_HUMAN
PhylomeDB	Q96NY7	http://phylomedb.org/?seqid=Q96NY7
ProteinModelPortal	Q96NY7	http://www.proteinmodelportal.org/query/uniprot/Q96NY7
PubMed	10830953	http://www.ncbi.nlm.nih.gov/pubmed/10830953
PubMed	12226712	http://www.ncbi.nlm.nih.gov/pubmed/12226712
PubMed	14597386	http://www.ncbi.nlm.nih.gov/pubmed/14597386
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
RefSeq	NP_001303938	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001303938
RefSeq	NP_444507	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_444507
SMR	Q96NY7	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q96NY7
STRING	9606.ENSP00000290332	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000290332&targetmode=cogs
SUPFAM	SSF47616	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47616
SUPFAM	SSF52833	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833
TCDB	1.A.12.1	http://www.tcdb.org/search/result.php?tc=1.A.12.1
TIGRFAMs	TIGR00862	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00862
UCSC	uc002yuf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002yuf&org=rat
UniGene	Hs.473695	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.473695
UniProtKB	CLIC6_HUMAN	http://www.uniprot.org/uniprot/CLIC6_HUMAN
UniProtKB-AC	Q96NY7	http://www.uniprot.org/uniprot/Q96NY7
charge	swissprot:CLIC6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CLIC6_HUMAN
eggNOG	ENOG410ZRK6	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZRK6
eggNOG	KOG1422	http://eggnogapi.embl.de/nog_data/html/tree/KOG1422
epestfind	swissprot:CLIC6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CLIC6_HUMAN
garnier	swissprot:CLIC6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CLIC6_HUMAN
helixturnhelix	swissprot:CLIC6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLIC6_HUMAN
hmoment	swissprot:CLIC6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CLIC6_HUMAN
iep	swissprot:CLIC6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CLIC6_HUMAN
inforesidue	swissprot:CLIC6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CLIC6_HUMAN
neXtProt	NX_Q96NY7	http://www.nextprot.org/db/entry/NX_Q96NY7
octanol	swissprot:CLIC6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CLIC6_HUMAN
pepcoil	swissprot:CLIC6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CLIC6_HUMAN
pepdigest	swissprot:CLIC6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CLIC6_HUMAN
pepinfo	swissprot:CLIC6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CLIC6_HUMAN
pepnet	swissprot:CLIC6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CLIC6_HUMAN
pepstats	swissprot:CLIC6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CLIC6_HUMAN
pepwheel	swissprot:CLIC6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CLIC6_HUMAN
pepwindow	swissprot:CLIC6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CLIC6_HUMAN
sigcleave	swissprot:CLIC6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CLIC6_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CNGB3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NQW8-1; Sequence=Displayed; Name=2; IsoId=Q9NQW8-2; Sequence=VSP_009742; Note=No experimental confirmation available.; 
# AltName	CNGB3_HUMAN	Cone photoreceptor cGMP-gated channel subunit beta
# AltName	CNGB3_HUMAN	Cyclic nucleotide-gated cation channel modulatory subunit
# AltName	CNGB3_HUMAN	Cyclic nucleotide-gated channel beta-3
# CCDS	CCDS6244	-. [Q9NQW8-1]
# DISEASE	CNGB3_HUMAN	Achromatopsia 3 (ACHM3) [MIM 262300]  An ocular stationary disorder due to the absence of functioning cone photoreceptors in the retina. It is characterized by total colorblindness, low visual acuity, photophobia and nystagmus. Achromatopsia type 3 patients manifest severe myopia. {ECO 0000269|PubMed 10888875, ECO 0000269|PubMed 10958649, ECO 0000269|PubMed 12357335, ECO 0000269|PubMed 14757870, ECO 0000269|PubMed 15657609, ECO 0000269|PubMed 15712225}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CNGB3_HUMAN	Stargardt disease 1 (STGD1) [MIM 248200]  A common hereditary macular degeneration. It is characterized by decreased central vision, atrophy of the macula and underlying retinal pigment epithelium, and frequent presence of prominent flecks in the posterior pole of the retina. {ECO 0000269|PubMed 15712225}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000320005	ENSP00000316605; ENSG00000170289. [Q9NQW8-1]
# ExpressionAtlas	Q9NQW8	baseline and differential
# FUNCTION	CNGB3_HUMAN	Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. {ECO 0000250, ECO 0000269|PubMed 10888875}. 
# GO_component	GO:0001750	photoreceptor outer segment; IEA:Ensembl.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:1902495	transmembrane transporter complex; IDA:UniProtKB.
# GO_function	GO:0005222	intracellular cAMP activated cation channel activity; IBA:GO_Central.
# GO_function	GO:0005223	intracellular cGMP activated cation channel activity; IDA:UniProtKB.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IBA:GO_Central.
# GO_function	GO:0030553	cGMP binding; IDA:UniProtKB.
# GO_process	GO:0006810	transport; NAS:ProtInc.
# GO_process	GO:0006812	cation transport; IDA:UniProtKB.
# GO_process	GO:0007165	signal transduction; NAS:ProtInc.
# GO_process	GO:0007601	visual perception; TAS:ProtInc.
# GO_process	GO:0042391	regulation of membrane potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# Gene3D	2.60.120.10	-; 1.
# Genevisible	Q9NQW8	HS
# HGNC	HGNC:2153	CNGB3
# InterPro	IPR000595	cNMP-bd_dom
# InterPro	IPR014710	RmlC-like_jellyroll
# InterPro	IPR018488	cNMP-bd_CS
# InterPro	IPR018490	cNMP-bd-like
# InterPro	IPR032943	CNG6
# KEGG_Brite	ko04040	Ion channels
# KEGG_Disease	H00819	[Nervous system disease; Eye disease] Fundus flavimaculatus
# KEGG_Disease	H00971	[Eye disease] Rod monochromacy
# MIM	248200	phenotype
# MIM	262300	phenotype
# MIM	605080	gene
# Organism	CNGB3_HUMAN	Homo sapiens (Human)
# Orphanet	1871	Progressive cone dystrophy
# Orphanet	49382	Achromatopsia
# Orphanet	827	Stargardt disease
# PANTHER	PTHR10217:SF385	PTHR10217:SF385
# PROSITE	PS00888	CNMP_BINDING_1
# PROSITE	PS00889	CNMP_BINDING_2
# PROSITE	PS50042	CNMP_BINDING_3
# Pfam	PF00027	cNMP_binding
# Proteomes	UP000005640	Chromosome 8
# RecName	CNGB3_HUMAN	Cyclic nucleotide-gated cation channel beta-3
# RefSeq	NP_061971	NM_019098.4. [Q9NQW8-1]
# SEQUENCE CAUTION	Sequence=AAF80179.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGB3 subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 cyclic nucleotide-binding domain. {ECO:0000255|PROSITE-ProRule	PRU00060}. 
# SMART	SM00100	cNMP
# SUBCELLULAR LOCATION	CNGB3_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	CNGB3_HUMAN	Tetramer formed of three CNGA3 and one CNGB3 modulatory subunits. {ECO 0000269|PubMed 10888875, ECO 0000269|PubMed 21878911}. 
# SUPFAM	SSF51206	SSF51206
# TISSUE SPECIFICITY	Expressed specifically in the retina. {ECO:0000269|PubMed	10958649}. 
# UCSC	uc003ydx	human. [Q9NQW8-1]
# eggNOG	ENOG410ZJ5U	LUCA
# eggNOG	KOG0499	Eukaryota
BLAST	swissprot:CNGB3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CNGB3_HUMAN
BioCyc	ZFISH:ENSG00000170289-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000170289-MONOMER
COXPRESdb	54714	http://coxpresdb.jp/data/gene/54714.shtml
CleanEx	HS_CNGB3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CNGB3
DOI	10.1002/humu.20142	http://dx.doi.org/10.1002/humu.20142
DOI	10.1038/77162	http://dx.doi.org/10.1038/77162
DOI	10.1038/nature04406	http://dx.doi.org/10.1038/nature04406
DOI	10.1038/ncomms1466	http://dx.doi.org/10.1038/ncomms1466
DOI	10.1038/sj.ejhg.5200856	http://dx.doi.org/10.1038/sj.ejhg.5200856
DOI	10.1038/sj.ejhg.5201269	http://dx.doi.org/10.1038/sj.ejhg.5201269
DOI	10.1093/hmg/9.14.2107	http://dx.doi.org/10.1093/hmg/9.14.2107
DOI	10.1136/jmg.2003.011437	http://dx.doi.org/10.1136/jmg.2003.011437
EMBL	AC013751	http://www.ebi.ac.uk/ena/data/view/AC013751
EMBL	AC090572	http://www.ebi.ac.uk/ena/data/view/AC090572
EMBL	AF228520	http://www.ebi.ac.uk/ena/data/view/AF228520
EMBL	AF272900	http://www.ebi.ac.uk/ena/data/view/AF272900
Ensembl	ENST00000320005	http://www.ensembl.org/id/ENST00000320005
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0001750	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001750
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:1902495	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902495
GO_function	GO:0005222	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005222
GO_function	GO:0005223	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005223
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0030553	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030553
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006812	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006812
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007601	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007601
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
Gene3D	2.60.120.10	http://www.cathdb.info/version/latest/superfamily/2.60.120.10
GeneCards	CNGB3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CNGB3
GeneID	54714	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54714
GeneTree	ENSGT00760000118772	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118772
H-InvDB	HIX0034272	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0034272
HGNC	HGNC:2153	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2153
HOGENOM	HOG000231425	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231425&db=HOGENOM6
HOVERGEN	HBG051038	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051038&db=HOVERGEN
HPA	CAB012803	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB012803
InParanoid	Q9NQW8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NQW8
InterPro	IPR000595	http://www.ebi.ac.uk/interpro/entry/IPR000595
InterPro	IPR014710	http://www.ebi.ac.uk/interpro/entry/IPR014710
InterPro	IPR018488	http://www.ebi.ac.uk/interpro/entry/IPR018488
InterPro	IPR018490	http://www.ebi.ac.uk/interpro/entry/IPR018490
InterPro	IPR032943	http://www.ebi.ac.uk/interpro/entry/IPR032943
Jabion	54714	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=54714
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00819	http://www.genome.jp/dbget-bin/www_bget?H00819
KEGG_Disease	H00971	http://www.genome.jp/dbget-bin/www_bget?H00971
KEGG_Gene	hsa:54714	http://www.genome.jp/dbget-bin/www_bget?hsa:54714
KEGG_Orthology	KO:K04953	http://www.genome.jp/dbget-bin/www_bget?KO:K04953
MIM	248200	http://www.ncbi.nlm.nih.gov/omim/248200
MIM	262300	http://www.ncbi.nlm.nih.gov/omim/262300
MIM	605080	http://www.ncbi.nlm.nih.gov/omim/605080
OMA	VDLFKGC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VDLFKGC
Orphanet	1871	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1871
Orphanet	49382	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=49382
Orphanet	827	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=827
OrthoDB	EOG091G03EW	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G03EW
PANTHER	PTHR10217:SF385	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10217:SF385
PROSITE	PS00888	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00888
PROSITE	PS00889	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00889
PROSITE	PS50042	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50042
PSORT	swissprot:CNGB3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CNGB3_HUMAN
PSORT-B	swissprot:CNGB3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CNGB3_HUMAN
PSORT2	swissprot:CNGB3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CNGB3_HUMAN
Pfam	PF00027	http://pfam.xfam.org/family/PF00027
PharmGKB	PA26663	http://www.pharmgkb.org/do/serve?objId=PA26663&objCls=Gene
Phobius	swissprot:CNGB3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CNGB3_HUMAN
PhylomeDB	Q9NQW8	http://phylomedb.org/?seqid=Q9NQW8
ProteinModelPortal	Q9NQW8	http://www.proteinmodelportal.org/query/uniprot/Q9NQW8
PubMed	10888875	http://www.ncbi.nlm.nih.gov/pubmed/10888875
PubMed	10958649	http://www.ncbi.nlm.nih.gov/pubmed/10958649
PubMed	12357335	http://www.ncbi.nlm.nih.gov/pubmed/12357335
PubMed	14757870	http://www.ncbi.nlm.nih.gov/pubmed/14757870
PubMed	15657609	http://www.ncbi.nlm.nih.gov/pubmed/15657609
PubMed	15712225	http://www.ncbi.nlm.nih.gov/pubmed/15712225
PubMed	16421571	http://www.ncbi.nlm.nih.gov/pubmed/16421571
PubMed	21878911	http://www.ncbi.nlm.nih.gov/pubmed/21878911
RefSeq	NP_061971	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061971
SMART	SM00100	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00100
STRING	9606.ENSP00000316605	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000316605&targetmode=cogs
SUPFAM	SSF51206	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51206
UCSC	uc003ydx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ydx&org=rat
UniGene	Hs.154433	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.154433
UniProtKB	CNGB3_HUMAN	http://www.uniprot.org/uniprot/CNGB3_HUMAN
UniProtKB-AC	Q9NQW8	http://www.uniprot.org/uniprot/Q9NQW8
charge	swissprot:CNGB3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CNGB3_HUMAN
eggNOG	ENOG410ZJ5U	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZJ5U
eggNOG	KOG0499	http://eggnogapi.embl.de/nog_data/html/tree/KOG0499
epestfind	swissprot:CNGB3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CNGB3_HUMAN
garnier	swissprot:CNGB3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CNGB3_HUMAN
helixturnhelix	swissprot:CNGB3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CNGB3_HUMAN
hmoment	swissprot:CNGB3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CNGB3_HUMAN
iep	swissprot:CNGB3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CNGB3_HUMAN
inforesidue	swissprot:CNGB3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CNGB3_HUMAN
neXtProt	NX_Q9NQW8	http://www.nextprot.org/db/entry/NX_Q9NQW8
octanol	swissprot:CNGB3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CNGB3_HUMAN
pepcoil	swissprot:CNGB3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CNGB3_HUMAN
pepdigest	swissprot:CNGB3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CNGB3_HUMAN
pepinfo	swissprot:CNGB3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CNGB3_HUMAN
pepnet	swissprot:CNGB3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CNGB3_HUMAN
pepstats	swissprot:CNGB3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CNGB3_HUMAN
pepwheel	swissprot:CNGB3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CNGB3_HUMAN
pepwindow	swissprot:CNGB3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CNGB3_HUMAN
sigcleave	swissprot:CNGB3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CNGB3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ITAV_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P06756-1; Sequence=Displayed; Name=2; IsoId=P06756-2; Sequence=VSP_024351; Note=No experimental confirmation available.; Name=3; IsoId=P06756-3; Sequence=VSP_044914; Note=No experimental confirmation available.; 
# AltName	ITAV_HUMAN	CD51
# AltName	ITAV_HUMAN	CD51
# AltName	ITAV_HUMAN	Vitronectin receptor subunit alpha
# BioGrid	109891	45
# CCDS	CCDS2292	-. [P06756-1]
# CCDS	CCDS46470	-. [P06756-2]
# CCDS	CCDS46471	-. [P06756-3]
# ChiTaRS	ITGAV	human
# DrugBank	DB00098	Anti-thymocyte Globulin (Rabbit)
# Ensembl	ENST00000261023	ENSP00000261023; ENSG00000138448. [P06756-1]
# Ensembl	ENST00000374907	ENSP00000364042; ENSG00000138448. [P06756-2]
# Ensembl	ENST00000433736	ENSP00000404291; ENSG00000138448. [P06756-3]
# ExpressionAtlas	P06756	baseline and differential
# FUNCTION	ITAV_HUMAN	(Microbial infection) Integrin ITGAV ITGB5 acts as a receptor for adenovirus type C (PubMed 20615244). Integrin ITGAV ITGB5 and ITGAV ITGB3 act as receptors for coxsackievirus A9 and B1 (PubMed 9426447, PubMed 15194773, PubMed 7519807). Integrin ITGAV ITGB3 acts as a receptor for herpes virus 8/HHV-8 (PubMed 18045938). Integrin ITGAV ITGB6 acts as a receptor for herpes simplex 1/HHV-1 (PubMed 24367260). Integrin ITGAV ITGB3 acts as a receptor for Human parechovirus 1 (PubMed 11160695). Integrin ITGAV ITGB3 acts as a receptor for West nile virus (PubMed 23658209). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions (PubMed 10397733). {ECO 0000269|PubMed 10397733, ECO 0000269|PubMed 11160695, ECO 0000269|PubMed 15194773, ECO 0000269|PubMed 18045938, ECO 0000269|PubMed 20615244, ECO 0000269|PubMed 23658209, ECO 0000269|PubMed 24367260, ECO 0000269|PubMed 7519807, ECO 0000269|PubMed 9426447}. 
# FUNCTION	ITAV_HUMAN	The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed 23125415). ITGAV ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed 20682778). ITGAV ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed 18441324). ITGAV ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed 19578119). ITGAV ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed 18635536, PubMed 25398877). ITGAV ITGB3 and ITGAV ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (PubMed 12807887, PubMed 17158881). {ECO 0000269|PubMed 12807887, ECO 0000269|PubMed 17158881, ECO 0000269|PubMed 18441324, ECO 0000269|PubMed 18635536, ECO 0000269|PubMed 19578119, ECO 0000269|PubMed 20682778, ECO 0000269|PubMed 23125415, ECO 0000269|PubMed 25398877}. 
# GO_component	GO:0005886	plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0005887	integral component of plasma membrane; NAS:UniProtKB.
# GO_component	GO:0005925	focal adhesion; IDA:UniProtKB.
# GO_component	GO:0008305	integrin complex; NAS:UniProtKB.
# GO_component	GO:0009897	external side of plasma membrane; IEA:Ensembl.
# GO_component	GO:0009986	cell surface; IDA:UniProtKB.
# GO_component	GO:0016020	membrane; ISS:BHF-UCL.
# GO_component	GO:0031258	lamellipodium membrane; IDA:UniProtKB.
# GO_component	GO:0031527	filopodium membrane; IDA:UniProtKB.
# GO_component	GO:0031528	microvillus membrane; IDA:UniProtKB.
# GO_component	GO:0032587	ruffle membrane; IDA:UniProtKB.
# GO_component	GO:0034683	integrin alphav-beta3 complex; IDA:UniProtKB.
# GO_component	GO:0034684	integrin alphav-beta5 complex; IDA:UniProtKB.
# GO_component	GO:0034686	integrin alphav-beta8 complex; IDA:UniProtKB.
# GO_component	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex; IDA:BHF-UCL.
# GO_component	GO:0045335	phagocytic vesicle; TAS:Reactome.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0001618	virus receptor activity; IEA:UniProtKB-KW.
# GO_function	GO:0001968	fibronectin binding; IDA:UniProtKB.
# GO_function	GO:0002020	protease binding; IDA:UniProtKB.
# GO_function	GO:0005245	voltage-gated calcium channel activity; IDA:UniProtKB.
# GO_function	GO:0015026	coreceptor activity; TAS:UniProtKB.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_function	GO:0050431	transforming growth factor beta binding; ISS:BHF-UCL.
# GO_function	GO:0050840	extracellular matrix binding; IDA:UniProtKB.
# GO_function	GO:1990430	extracellular matrix protein binding; IDA:UniProtKB.
# GO_process	GO:0001525	angiogenesis; IEP:UniProtKB.
# GO_process	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome.
# GO_process	GO:0007155	cell adhesion; IDA:BHF-UCL.
# GO_process	GO:0007160	cell-matrix adhesion; IDA:UniProtKB.
# GO_process	GO:0007229	integrin-mediated signaling pathway; NAS:UniProtKB.
# GO_process	GO:0008284	positive regulation of cell proliferation; IDA:BHF-UCL.
# GO_process	GO:0010745	negative regulation of macrophage derived foam cell differentiation; IMP:BHF-UCL.
# GO_process	GO:0010888	negative regulation of lipid storage; IMP:BHF-UCL.
# GO_process	GO:0016049	cell growth; IMP:UniProtKB.
# GO_process	GO:0016477	cell migration; IMP:UniProtKB.
# GO_process	GO:0030198	extracellular matrix organization; TAS:Reactome.
# GO_process	GO:0030335	positive regulation of cell migration; IEA:Ensembl.
# GO_process	GO:0031589	cell-substrate adhesion; IMP:UniProtKB.
# GO_process	GO:0032369	negative regulation of lipid transport; IMP:BHF-UCL.
# GO_process	GO:0033627	cell adhesion mediated by integrin; IDA:UniProtKB.
# GO_process	GO:0033690	positive regulation of osteoblast proliferation; IEA:Ensembl.
# GO_process	GO:0034113	heterotypic cell-cell adhesion; IMP:UniProtKB.
# GO_process	GO:0034446	substrate adhesion-dependent cell spreading; IDA:UniProtKB.
# GO_process	GO:0035987	endodermal cell differentiation; IMP:UniProtKB.
# GO_process	GO:0038027	apolipoprotein A-I-mediated signaling pathway; IMP:UniProtKB.
# GO_process	GO:0043277	apoptotic cell clearance; IEA:Ensembl.
# GO_process	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process; IMP:BHF-UCL.
# GO_process	GO:0045785	positive regulation of cell adhesion; IDA:BHF-UCL.
# GO_process	GO:0046718	viral entry into host cell; IMP:UniProtKB.
# GO_process	GO:0048010	vascular endothelial growth factor receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0050748	negative regulation of lipoprotein metabolic process; IMP:BHF-UCL.
# GO_process	GO:0050764	regulation of phagocytosis; IDA:BHF-UCL.
# GO_process	GO:0050900	leukocyte migration; TAS:Reactome.
# GO_process	GO:0050919	negative chemotaxis; IMP:UniProtKB.
# GO_process	GO:0052066	entry of symbiont into host cell by promotion of host phagocytosis; NAS:BHF-UCL.
# GO_process	GO:0070371	ERK1 and ERK2 cascade; ISS:BHF-UCL.
# GO_process	GO:0070588	calcium ion transmembrane transport; IDA:UniProtKB.
# GO_process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand; ISS:BHF-UCL.
# GO_process	GO:2000425	regulation of apoptotic cell clearance; ISS:BHF-UCL.
# GO_process	GO:2000536	negative regulation of entry of bacterium into host cell; IDA:BHF-UCL.
# GO_process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway; IMP:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0000902	cell morphogenesis
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0007155	cell adhesion
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0030198	extracellular matrix organization
# GOslim_process	GO:0040007	growth
# GOslim_process	GO:0040011	locomotion
# GOslim_process	GO:0048646	anatomical structure formation involved in morphogenesis
# GOslim_process	GO:0048870	cell motility
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P06756	HS
# HGNC	HGNC:6150	ITGAV
# INTERACTION	ITAV_HUMAN	P05106 ITGB3; NbExp=11; IntAct=EBI-298282, EBI-702847; P18084 ITGB5; NbExp=2; IntAct=EBI-298282, EBI-1223434; 
# IntAct	P06756	14
# InterPro	IPR000413	Integrin_alpha
# InterPro	IPR013517	FG-GAP
# InterPro	IPR013519	Int_alpha_beta-p
# InterPro	IPR013649	Integrin_alpha-2
# InterPro	IPR018184	Integrin_alpha_C_CS
# InterPro	IPR032695	Integrin_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04090	 Cellular antigens
# KEGG_Brite	ko04516	 Cell adhesion molecules and their ligands
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko04151	PI3K-Akt signaling pathway
# KEGG_Pathway	ko04510	Focal adhesion
# KEGG_Pathway	ko04512	ECM-receptor interaction
# KEGG_Pathway	ko04514	Cell adhesion molecules (CAMs)
# KEGG_Pathway	ko04810	Regulation of actin cytoskeleton
# KEGG_Pathway	ko05200	Pathways in cancer
# KEGG_Pathway	ko05222	Small cell lung cancer
# KEGG_Pathway	ko05410	Hypertrophic cardiomyopathy (HCM)
# KEGG_Pathway	ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
# KEGG_Pathway	ko05414	Dilated cardiomyopathy
# MIM	193210	gene
# Organism	ITAV_HUMAN	Homo sapiens (Human)
# PDB	1JV2	X-ray; 3.10 A; A=31-987
# PDB	1L5G	X-ray; 3.20 A; A=31-987
# PDB	1M1X	X-ray; 3.30 A; A=31-987
# PDB	1U8C	X-ray; 3.10 A; A=31-987
# PDB	3IJE	X-ray; 2.90 A; A=31-997
# PDB	4G1E	X-ray; 3.00 A; A=31-989
# PDB	4G1M	X-ray; 2.90 A; A=31-989
# PDB	4MMX	X-ray; 3.32 A; A=31-989
# PDB	4MMY	X-ray; 3.18 A; A=31-989
# PDB	4MMZ	X-ray; 3.10 A; A=31-989
# PDB	4O02	X-ray; 3.60 A; A=31-992
# PDB	4UM8	X-ray; 2.85 A; A/C=31-625
# PDB	4UM9	X-ray; 2.50 A; A/C=31-625
# PIR	A27421	A27421
# PRINTS	PR01185	INTEGRINA
# PROSITE	PS00242	INTEGRIN_ALPHA
# PROSITE	PS51470	FG_GAP; 7
# Pfam	PF00357	Integrin_alpha
# Pfam	PF01839	FG-GAP; 3
# Pfam	PF08441	Integrin_alpha2
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-1236973	Cross-presentation of particulate exogenous antigens (phagosomes)
# Reactome	R-HSA-1566948	Elastic fibre formation
# Reactome	R-HSA-210990	PECAM1 interactions
# Reactome	R-HSA-2129379	Molecules associated with elastic fibres
# Reactome	R-HSA-216083	Integrin cell surface interactions
# Reactome	R-HSA-3000157	Laminin interactions
# Reactome	R-HSA-3000170	Syndecan interactions
# Reactome	R-HSA-3000178	ECM proteoglycans
# Reactome	R-HSA-4420097	VEGFA-VEGFR2 Pathway
# Reactome	R-HSA-445144	Signal transduction by L1
# Reactome	R-HSA-6798695	Neutrophil degranulation
# RecName	ITAV_HUMAN	Integrin alpha-V
# RecName	ITAV_HUMAN	Integrin alpha-V heavy chain
# RecName	ITAV_HUMAN	Integrin alpha-V heavy chain
# RecName	ITAV_HUMAN	Integrin alpha-V light chain
# RefSeq	NP_001138471	NM_001144999.2
# RefSeq	NP_001138472	NM_001145000.2
# RefSeq	NP_002201	NM_002210.4
# SEQUENCE CAUTION	Sequence=BAD93131.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the integrin alpha chain family. {ECO	0000305}. 
# SIMILARITY	Contains 7 FG-GAP repeats. {ECO:0000255|PROSITE- ProRule	PRU00803}. 
# SMART	SM00191	Int_alpha; 5
# SUBCELLULAR LOCATION	ITAV_HUMAN	Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion {ECO 0000269|PubMed 17158881}. 
# SUBUNIT	(Microbial infection) Integrin ITGAV:ITGB3 interacts with Human parechovirus 1 capsid proteins. {ECO	0000269|PubMed:11160695}. 
# SUBUNIT	(Microbial infection) Integrin ITGAV:ITGB3 interacts with West nile virus envelope protein E. {ECO	0000269|PubMed:23658209}. 
# SUBUNIT	(Microbial infection) Integrin ITGAV:ITGB3 interacts with herpes virus 8/HHV-8 envelope glycoprotein B. {ECO	0000269|PubMed:18045938}. 
# SUBUNIT	(Microbial infection) Integrin ITGAV:ITGB5 interacts with adenovirus type C penton protein. {ECO	0000269|PubMed:20615244}. 
# SUBUNIT	(Microbial infection) Integrin ITGAV:ITGB6 interacts with herpes simplex 1/HHV-1 envelope glycoprotein H. {ECO	0000269|PubMed:24367260}. 
# SUBUNIT	(Microbial infection) Interacts with HIV-1 Tat. {ECO:0000269|PubMed	10397733}. 
# SUBUNIT	ITAV_HUMAN	(Microbial infection) Integrin ITGAV ITGB3 and ITGAV ITGB6 bind to coxsackievirus A9 and coxsackievirus B1 capsid proteins (PubMed 9426447, PubMed 15194773, PubMed 7519807). {ECO 0000269|PubMed 15194773, ECO 0000269|PubMed 7519807, ECO 0000269|PubMed 9426447}. 
# SUBUNIT	ITAV_HUMAN	Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-V (ITGAV) associates with either beta-1 (ITGB1), beta-3 (ITGB3), beta-5 (ITGB5), beta-6 (ITGB6) or beta-8 (ITGB8). Interacts with CIB1 (PubMed 24011356). Interacts with RAB25 (PubMed 17925226). Integrins ITGAV ITGB3 and ITGAV ITGB5 interact with FBLN5 (via N-terminus) (By similarity). ITGAV ITGB3 and ITGAV ITGB5 interact with NOV (PubMed 12695522). ITGAV ITGB3 interacts with ADGRA2 (PubMed 16982628). ITGAV ITGB3 is found in a ternary complex with CX3CR1 and CX3CL1 (PubMed 23125415). ITGAV ITGB3 is found in a ternary complex with NRG1 and ERBB3 (PubMed 20682778). ITGAV ITGB3 is found in a ternary complex with FGF1 and FGFR1 (PubMed 18441324). ITGAV ITGB3 is found in a ternary complex with IGF1 and IGF1R (PubMed 19578119). ITGAV ITGB3 and ITGAV ITGB6 interact with FBN1 (PubMed 12807887, PubMed 17158881). {ECO 0000250|UniProtKB P43406, ECO 0000250|UniProtKB P80746, ECO 0000269|PubMed 12695522, ECO 0000269|PubMed 12807887, ECO 0000269|PubMed 16982628, ECO 0000269|PubMed 17158881, ECO 0000269|PubMed 17925226, ECO 0000269|PubMed 18441324, ECO 0000269|PubMed 19578119, ECO 0000269|PubMed 20615244, ECO 0000269|PubMed 20682778, ECO 0000269|PubMed 23125415, ECO 0000269|PubMed 23658209, ECO 0000269|PubMed 24011356}. 
# SUPFAM	SSF69179	SSF69179; 3
# UCSC	uc002upq	human. [P06756-1]
# eggNOG	ENOG410IPB5	Eukaryota
# eggNOG	ENOG410YR19	LUCA
BLAST	swissprot:ITAV_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ITAV_HUMAN
BioCyc	ZFISH:ENSG00000138448-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000138448-MONOMER
COXPRESdb	3685	http://coxpresdb.jp/data/gene/3685.shtml
CleanEx	HS_ITGAV	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ITGAV
DIP	DIP-31785N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31785N
DOI	10.1006/viro.1994.1494	http://dx.doi.org/10.1006/viro.1994.1494
DOI	10.1006/viro.1997.8831	http://dx.doi.org/10.1006/viro.1997.8831
DOI	10.1016/0092-8674(89)90172-4	http://dx.doi.org/10.1016/0092-8674(89)90172-4
DOI	10.1016/0167-4781(94)90278-X	http://dx.doi.org/10.1016/0167-4781(94)90278-X
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.devcel.2007.08.012	http://dx.doi.org/10.1016/j.devcel.2007.08.012
DOI	10.1021/bi034726u	http://dx.doi.org/10.1021/bi034726u
DOI	10.1021/bi400678y	http://dx.doi.org/10.1021/bi400678y
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/nbt.1532	http://dx.doi.org/10.1038/nbt.1532
DOI	10.1038/nbt827	http://dx.doi.org/10.1038/nbt827
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.83.22.8614	http://dx.doi.org/10.1073/pnas.83.22.8614
DOI	10.1074/jbc.M109.013201	http://dx.doi.org/10.1074/jbc.M109.013201
DOI	10.1074/jbc.M110.113878	http://dx.doi.org/10.1074/jbc.M110.113878
DOI	10.1074/jbc.M114.579946	http://dx.doi.org/10.1074/jbc.M114.579946
DOI	10.1074/jbc.M302028200	http://dx.doi.org/10.1074/jbc.M302028200
DOI	10.1074/jbc.M303159200	http://dx.doi.org/10.1074/jbc.M303159200
DOI	10.1074/jbc.M605291200	http://dx.doi.org/10.1074/jbc.M605291200
DOI	10.1074/jbc.M607008200	http://dx.doi.org/10.1074/jbc.M607008200
DOI	10.1074/jbc.M801213200	http://dx.doi.org/10.1074/jbc.M801213200
DOI	10.1074/jbc.M804835200	http://dx.doi.org/10.1074/jbc.M804835200
DOI	10.1099/vir.0.052613-0	http://dx.doi.org/10.1099/vir.0.052613-0
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1064535	http://dx.doi.org/10.1126/science.1064535
DOI	10.1128/JVI.01673-07	http://dx.doi.org/10.1128/JVI.01673-07
DOI	10.1128/JVI.75.4.1958-1967.2001	http://dx.doi.org/10.1128/JVI.75.4.1958-1967.2001
DOI	10.1128/JVI.78.13.6967-6973.2004	http://dx.doi.org/10.1128/JVI.78.13.6967-6973.2004
DOI	10.1186/1743-422X-7-148	http://dx.doi.org/10.1186/1743-422X-7-148
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1371/journal.ppat.1003806	http://dx.doi.org/10.1371/journal.ppat.1003806
DOI	10.4049/jimmunol.1200889	http://dx.doi.org/10.4049/jimmunol.1200889
DrugBank	DB00098	http://www.drugbank.ca/drugs/DB00098
EMBL	AB209894	http://www.ebi.ac.uk/ena/data/view/AB209894
EMBL	AC017101	http://www.ebi.ac.uk/ena/data/view/AC017101
EMBL	AF251818	http://www.ebi.ac.uk/ena/data/view/AF251818
EMBL	AF251819	http://www.ebi.ac.uk/ena/data/view/AF251819
EMBL	AF251820	http://www.ebi.ac.uk/ena/data/view/AF251820
EMBL	AF251821	http://www.ebi.ac.uk/ena/data/view/AF251821
EMBL	AF251822	http://www.ebi.ac.uk/ena/data/view/AF251822
EMBL	AF251823	http://www.ebi.ac.uk/ena/data/view/AF251823
EMBL	AF251824	http://www.ebi.ac.uk/ena/data/view/AF251824
EMBL	AF251825	http://www.ebi.ac.uk/ena/data/view/AF251825
EMBL	AF251826	http://www.ebi.ac.uk/ena/data/view/AF251826
EMBL	AF251827	http://www.ebi.ac.uk/ena/data/view/AF251827
EMBL	AF251828	http://www.ebi.ac.uk/ena/data/view/AF251828
EMBL	AF251829	http://www.ebi.ac.uk/ena/data/view/AF251829
EMBL	AF251830	http://www.ebi.ac.uk/ena/data/view/AF251830
EMBL	AF251831	http://www.ebi.ac.uk/ena/data/view/AF251831
EMBL	AF251832	http://www.ebi.ac.uk/ena/data/view/AF251832
EMBL	AF251833	http://www.ebi.ac.uk/ena/data/view/AF251833
EMBL	AF251834	http://www.ebi.ac.uk/ena/data/view/AF251834
EMBL	AF251835	http://www.ebi.ac.uk/ena/data/view/AF251835
EMBL	AF251836	http://www.ebi.ac.uk/ena/data/view/AF251836
EMBL	AF251837	http://www.ebi.ac.uk/ena/data/view/AF251837
EMBL	AF251838	http://www.ebi.ac.uk/ena/data/view/AF251838
EMBL	AF251839	http://www.ebi.ac.uk/ena/data/view/AF251839
EMBL	AF251840	http://www.ebi.ac.uk/ena/data/view/AF251840
EMBL	AF251841	http://www.ebi.ac.uk/ena/data/view/AF251841
EMBL	AK302990	http://www.ebi.ac.uk/ena/data/view/AK302990
EMBL	BC126231	http://www.ebi.ac.uk/ena/data/view/BC126231
EMBL	BC136442	http://www.ebi.ac.uk/ena/data/view/BC136442
EMBL	BC144100	http://www.ebi.ac.uk/ena/data/view/BC144100
EMBL	CH471058	http://www.ebi.ac.uk/ena/data/view/CH471058
EMBL	EU332844	http://www.ebi.ac.uk/ena/data/view/EU332844
EMBL	M14648	http://www.ebi.ac.uk/ena/data/view/M14648
EMBL	U07375	http://www.ebi.ac.uk/ena/data/view/U07375
Ensembl	ENST00000261023	http://www.ensembl.org/id/ENST00000261023
Ensembl	ENST00000374907	http://www.ensembl.org/id/ENST00000374907
Ensembl	ENST00000433736	http://www.ensembl.org/id/ENST00000433736
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005925	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005925
GO_component	GO:0008305	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008305
GO_component	GO:0009897	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009897
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0031258	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031258
GO_component	GO:0031527	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031527
GO_component	GO:0031528	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031528
GO_component	GO:0032587	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032587
GO_component	GO:0034683	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034683
GO_component	GO:0034684	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034684
GO_component	GO:0034686	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034686
GO_component	GO:0035867	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035867
GO_component	GO:0045335	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045335
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0001618	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001618
GO_function	GO:0001968	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001968
GO_function	GO:0002020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002020
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0015026	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015026
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_function	GO:0050431	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050431
GO_function	GO:0050840	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050840
GO_function	GO:1990430	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990430
GO_process	GO:0001525	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001525
GO_process	GO:0002479	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002479
GO_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GO_process	GO:0007160	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007160
GO_process	GO:0007229	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007229
GO_process	GO:0008284	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008284
GO_process	GO:0010745	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010745
GO_process	GO:0010888	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010888
GO_process	GO:0016049	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016049
GO_process	GO:0016477	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016477
GO_process	GO:0030198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030198
GO_process	GO:0030335	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030335
GO_process	GO:0031589	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031589
GO_process	GO:0032369	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032369
GO_process	GO:0033627	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033627
GO_process	GO:0033690	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033690
GO_process	GO:0034113	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034113
GO_process	GO:0034446	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034446
GO_process	GO:0035987	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035987
GO_process	GO:0038027	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0038027
GO_process	GO:0043277	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043277
GO_process	GO:0045715	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045715
GO_process	GO:0045785	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045785
GO_process	GO:0046718	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046718
GO_process	GO:0048010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048010
GO_process	GO:0050748	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050748
GO_process	GO:0050764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050764
GO_process	GO:0050900	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050900
GO_process	GO:0050919	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050919
GO_process	GO:0052066	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052066
GO_process	GO:0070371	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070371
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:0097192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097192
GO_process	GO:2000425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000425
GO_process	GO:2000536	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000536
GO_process	GO:2001237	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001237
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0000902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000902
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0030198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030198
GOslim_process	GO:0040007	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040007
GOslim_process	GO:0040011	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011
GOslim_process	GO:0048646	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048646
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ITGAV	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ITGAV
GeneID	3685	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3685
GeneTree	ENSGT00760000118782	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118782
HGNC	HGNC:6150	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6150
HOGENOM	HOG000231603	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231603&db=HOGENOM6
HOVERGEN	HBG006186	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006186&db=HOVERGEN
HPA	CAB002499	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB002499
HPA	HPA004856	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA004856
InParanoid	P06756	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06756
IntAct	P06756	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06756*
InterPro	IPR000413	http://www.ebi.ac.uk/interpro/entry/IPR000413
InterPro	IPR013517	http://www.ebi.ac.uk/interpro/entry/IPR013517
InterPro	IPR013519	http://www.ebi.ac.uk/interpro/entry/IPR013519
InterPro	IPR013649	http://www.ebi.ac.uk/interpro/entry/IPR013649
InterPro	IPR018184	http://www.ebi.ac.uk/interpro/entry/IPR018184
InterPro	IPR032695	http://www.ebi.ac.uk/interpro/entry/IPR032695
Jabion	3685	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3685
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04090	http://www.genome.jp/dbget-bin/www_bget?ko04090
KEGG_Brite	ko04516	http://www.genome.jp/dbget-bin/www_bget?ko04516
KEGG_Gene	hsa:3685	http://www.genome.jp/dbget-bin/www_bget?hsa:3685
KEGG_Orthology	KO:K06487	http://www.genome.jp/dbget-bin/www_bget?KO:K06487
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko04151	http://www.genome.jp/kegg-bin/show_pathway?ko04151
KEGG_Pathway	ko04510	http://www.genome.jp/kegg-bin/show_pathway?ko04510
KEGG_Pathway	ko04512	http://www.genome.jp/kegg-bin/show_pathway?ko04512
KEGG_Pathway	ko04514	http://www.genome.jp/kegg-bin/show_pathway?ko04514
KEGG_Pathway	ko04810	http://www.genome.jp/kegg-bin/show_pathway?ko04810
KEGG_Pathway	ko05200	http://www.genome.jp/kegg-bin/show_pathway?ko05200
KEGG_Pathway	ko05222	http://www.genome.jp/kegg-bin/show_pathway?ko05222
KEGG_Pathway	ko05410	http://www.genome.jp/kegg-bin/show_pathway?ko05410
KEGG_Pathway	ko05412	http://www.genome.jp/kegg-bin/show_pathway?ko05412
KEGG_Pathway	ko05414	http://www.genome.jp/kegg-bin/show_pathway?ko05414
MIM	193210	http://www.ncbi.nlm.nih.gov/omim/193210
MINT	MINT-209462	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-209462
OMA	SCFNVRF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SCFNVRF
OrthoDB	EOG091G05Z4	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05Z4
PDB	1JV2	http://www.ebi.ac.uk/pdbe-srv/view/entry/1JV2
PDB	1L5G	http://www.ebi.ac.uk/pdbe-srv/view/entry/1L5G
PDB	1M1X	http://www.ebi.ac.uk/pdbe-srv/view/entry/1M1X
PDB	1U8C	http://www.ebi.ac.uk/pdbe-srv/view/entry/1U8C
PDB	3IJE	http://www.ebi.ac.uk/pdbe-srv/view/entry/3IJE
PDB	4G1E	http://www.ebi.ac.uk/pdbe-srv/view/entry/4G1E
PDB	4G1M	http://www.ebi.ac.uk/pdbe-srv/view/entry/4G1M
PDB	4MMX	http://www.ebi.ac.uk/pdbe-srv/view/entry/4MMX
PDB	4MMY	http://www.ebi.ac.uk/pdbe-srv/view/entry/4MMY
PDB	4MMZ	http://www.ebi.ac.uk/pdbe-srv/view/entry/4MMZ
PDB	4O02	http://www.ebi.ac.uk/pdbe-srv/view/entry/4O02
PDB	4UM8	http://www.ebi.ac.uk/pdbe-srv/view/entry/4UM8
PDB	4UM9	http://www.ebi.ac.uk/pdbe-srv/view/entry/4UM9
PDBsum	1JV2	http://www.ebi.ac.uk/pdbsum/1JV2
PDBsum	1L5G	http://www.ebi.ac.uk/pdbsum/1L5G
PDBsum	1M1X	http://www.ebi.ac.uk/pdbsum/1M1X
PDBsum	1U8C	http://www.ebi.ac.uk/pdbsum/1U8C
PDBsum	3IJE	http://www.ebi.ac.uk/pdbsum/3IJE
PDBsum	4G1E	http://www.ebi.ac.uk/pdbsum/4G1E
PDBsum	4G1M	http://www.ebi.ac.uk/pdbsum/4G1M
PDBsum	4MMX	http://www.ebi.ac.uk/pdbsum/4MMX
PDBsum	4MMY	http://www.ebi.ac.uk/pdbsum/4MMY
PDBsum	4MMZ	http://www.ebi.ac.uk/pdbsum/4MMZ
PDBsum	4O02	http://www.ebi.ac.uk/pdbsum/4O02
PDBsum	4UM8	http://www.ebi.ac.uk/pdbsum/4UM8
PDBsum	4UM9	http://www.ebi.ac.uk/pdbsum/4UM9
PRINTS	PR01185	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01185
PROSITE	PS00242	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00242
PROSITE	PS51470	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51470
PSORT	swissprot:ITAV_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ITAV_HUMAN
PSORT-B	swissprot:ITAV_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ITAV_HUMAN
PSORT2	swissprot:ITAV_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ITAV_HUMAN
Pfam	PF00357	http://pfam.xfam.org/family/PF00357
Pfam	PF01839	http://pfam.xfam.org/family/PF01839
Pfam	PF08441	http://pfam.xfam.org/family/PF08441
PharmGKB	PA37336	http://www.pharmgkb.org/do/serve?objId=PA37336&objCls=Gene
Phobius	swissprot:ITAV_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ITAV_HUMAN
PhylomeDB	P06756	http://phylomedb.org/?seqid=P06756
ProteinModelPortal	P06756	http://www.proteinmodelportal.org/query/uniprot/P06756
PubMed	10397733	http://www.ncbi.nlm.nih.gov/pubmed/10397733
PubMed	10965141	http://www.ncbi.nlm.nih.gov/pubmed/10965141
PubMed	11160695	http://www.ncbi.nlm.nih.gov/pubmed/11160695
PubMed	11546839	http://www.ncbi.nlm.nih.gov/pubmed/11546839
PubMed	12695522	http://www.ncbi.nlm.nih.gov/pubmed/12695522
PubMed	12754519	http://www.ncbi.nlm.nih.gov/pubmed/12754519
PubMed	12807887	http://www.ncbi.nlm.nih.gov/pubmed/12807887
PubMed	14596610	http://www.ncbi.nlm.nih.gov/pubmed/14596610
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15194773	http://www.ncbi.nlm.nih.gov/pubmed/15194773
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	16982628	http://www.ncbi.nlm.nih.gov/pubmed/16982628
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	17158881	http://www.ncbi.nlm.nih.gov/pubmed/17158881
PubMed	17925226	http://www.ncbi.nlm.nih.gov/pubmed/17925226
PubMed	18045938	http://www.ncbi.nlm.nih.gov/pubmed/18045938
PubMed	18441324	http://www.ncbi.nlm.nih.gov/pubmed/18441324
PubMed	18635536	http://www.ncbi.nlm.nih.gov/pubmed/18635536
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	19349973	http://www.ncbi.nlm.nih.gov/pubmed/19349973
PubMed	19578119	http://www.ncbi.nlm.nih.gov/pubmed/19578119
PubMed	20615244	http://www.ncbi.nlm.nih.gov/pubmed/20615244
PubMed	20682778	http://www.ncbi.nlm.nih.gov/pubmed/20682778
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23125415	http://www.ncbi.nlm.nih.gov/pubmed/23125415
PubMed	23658209	http://www.ncbi.nlm.nih.gov/pubmed/23658209
PubMed	24011356	http://www.ncbi.nlm.nih.gov/pubmed/24011356
PubMed	2430295	http://www.ncbi.nlm.nih.gov/pubmed/2430295
PubMed	24367260	http://www.ncbi.nlm.nih.gov/pubmed/24367260
PubMed	2443500	http://www.ncbi.nlm.nih.gov/pubmed/2443500
PubMed	2467745	http://www.ncbi.nlm.nih.gov/pubmed/2467745
PubMed	25398877	http://www.ncbi.nlm.nih.gov/pubmed/25398877
PubMed	7519807	http://www.ncbi.nlm.nih.gov/pubmed/7519807
PubMed	7522056	http://www.ncbi.nlm.nih.gov/pubmed/7522056
PubMed	9426447	http://www.ncbi.nlm.nih.gov/pubmed/9426447
Reactome	R-HSA-1236973	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1236973
Reactome	R-HSA-1566948	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1566948
Reactome	R-HSA-210990	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-210990
Reactome	R-HSA-2129379	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2129379
Reactome	R-HSA-216083	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-216083
Reactome	R-HSA-3000157	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3000157
Reactome	R-HSA-3000170	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3000170
Reactome	R-HSA-3000178	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3000178
Reactome	R-HSA-4420097	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-4420097
Reactome	R-HSA-445144	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-445144
Reactome	R-HSA-6798695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6798695
RefSeq	NP_001138471	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001138471
RefSeq	NP_001138472	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001138472
RefSeq	NP_002201	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002201
SMART	SM00191	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00191
SMR	P06756	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06756
STRING	9606.ENSP00000261023	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000261023&targetmode=cogs
SUPFAM	SSF69179	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF69179
UCSC	uc002upq	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002upq&org=rat
UniGene	Hs.436873	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.436873
UniProtKB	ITAV_HUMAN	http://www.uniprot.org/uniprot/ITAV_HUMAN
UniProtKB-AC	P06756	http://www.uniprot.org/uniprot/P06756
charge	swissprot:ITAV_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ITAV_HUMAN
eggNOG	ENOG410IPB5	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IPB5
eggNOG	ENOG410YR19	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YR19
epestfind	swissprot:ITAV_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ITAV_HUMAN
garnier	swissprot:ITAV_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ITAV_HUMAN
helixturnhelix	swissprot:ITAV_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ITAV_HUMAN
hmoment	swissprot:ITAV_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ITAV_HUMAN
iep	swissprot:ITAV_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ITAV_HUMAN
inforesidue	swissprot:ITAV_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ITAV_HUMAN
neXtProt	NX_P06756	http://www.nextprot.org/db/entry/NX_P06756
octanol	swissprot:ITAV_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ITAV_HUMAN
pepcoil	swissprot:ITAV_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ITAV_HUMAN
pepdigest	swissprot:ITAV_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ITAV_HUMAN
pepinfo	swissprot:ITAV_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ITAV_HUMAN
pepnet	swissprot:ITAV_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ITAV_HUMAN
pepstats	swissprot:ITAV_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ITAV_HUMAN
pepwheel	swissprot:ITAV_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ITAV_HUMAN
pepwindow	swissprot:ITAV_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ITAV_HUMAN
sigcleave	swissprot:ITAV_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ITAV_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S39AE_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q15043-1; Sequence=Displayed; Name=2; IsoId=Q15043-2; Sequence=VSP_029728; Note=No experimental confirmation available.; Name=3; IsoId=Q15043-3; Sequence=VSP_040139; 
# AltName	S39AE_HUMAN	LIV-1 subfamily of ZIP zinc transporter 4
# AltName	S39AE_HUMAN	Solute carrier family 39 member 14
# AltName	S39AE_HUMAN	Zrt- and Irt-like protein 14
# BioGrid	117063	5
# CCDS	CCDS47822	-. [Q15043-2]
# CCDS	CCDS47823	-. [Q15043-1]
# CCDS	CCDS6030	-. [Q15043-3]
# ChiTaRS	SLC39A14	human
# Ensembl	ENST00000240095	ENSP00000240095; ENSG00000104635. [Q15043-2]
# Ensembl	ENST00000289952	ENSP00000289952; ENSG00000104635. [Q15043-1]
# Ensembl	ENST00000359741	ENSP00000352779; ENSG00000104635. [Q15043-3]
# Ensembl	ENST00000381237	ENSP00000370635; ENSG00000104635. [Q15043-1]
# ExpressionAtlas	Q15043	baseline and differential
# FUNCTION	S39AE_HUMAN	May mediate cellular uptake of nontransferrin-bound iron (By similarity). Broad-scope metal ion transporter with a preference for zinc uptake. {ECO 0000250, ECO 0000269|PubMed 15642354}. 
# GO_component	GO:0005783	endoplasmic reticulum; IDA:HPA.
# GO_component	GO:0005794	Golgi apparatus; IDA:HPA.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0016021	integral component of membrane; IDA:BHF-UCL.
# GO_component	GO:0030027	lamellipodium; IEA:UniProtKB-SubCell.
# GO_function	GO:0005385	zinc ion transmembrane transporter activity; IDA:BHF-UCL.
# GO_function	GO:0015093	ferrous iron transmembrane transporter activity; IEA:Ensembl.
# GO_process	GO:0006882	cellular zinc ion homeostasis; IDA:BHF-UCL.
# GO_process	GO:0071577	zinc II ion transmembrane transport; IMP:UniProtKB.
# GO_process	GO:0071578	zinc II ion transmembrane import; IDA:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q15043	HS
# HGNC	HGNC:20858	SLC39A14
# IntAct	Q15043	6
# InterPro	IPR003689	ZIP
# KEGG_Brite	ko02001	Solute carrier family
# MIM	608736	gene
# Organism	S39AE_HUMAN	Homo sapiens (Human)
# Pfam	PF02535	Zip
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-442380	Zinc influx into cells by the SLC39 gene family
# RecName	S39AE_HUMAN	Zinc transporter ZIP14
# RefSeq	NP_001121903	NM_001128431.2. [Q15043-1]
# RefSeq	NP_001128625	NM_001135153.1. [Q15043-1]
# RefSeq	NP_001128626	NM_001135154.1. [Q15043-2]
# RefSeq	NP_056174	NM_015359.4. [Q15043-3]
# RefSeq	XP_005273522	XM_005273465.2. [Q15043-1]
# RefSeq	XP_005273523	XM_005273466.4. [Q15043-1]
# RefSeq	XP_006716387	XM_006716324.2. [Q15043-1]
# RefSeq	XP_011542780	XM_011544478.2. [Q15043-1]
# RefSeq	XP_016868783	XM_017013294.1. [Q15043-1]
# RefSeq	XP_016868784	XM_017013295.1. [Q15043-1]
# SEQUENCE CAUTION	Sequence=BAA06685.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the ZIP transporter (TC 2.A.5) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S39AE_HUMAN	Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. Cell projection, lamellipodium {ECO 0000269|PubMed 12659941, ECO 0000269|PubMed 15642354}. Note=Localized to the plasma membrane and also found colocalized with F-actin concentrated on lamellipodiae. 
# SUBUNIT	Homotrimer. {ECO:0000269|PubMed	12659941}. 
# TCDB	2.A.5.4	the zinc (zn(2+))-iron (fe(2+)) permease (zip) family
# TISSUE SPECIFICITY	S39AE_HUMAN	Ubiquitously expressed, with increased expression in liver, pancreas, fetal liver, thyroid gland, left and right ventricle, right atrium and fetal heart. Weakly expressed in spleen, thymus, and peripheral blood leukocytes. {ECO 0000269|PubMed 15642354, ECO 0000269|PubMed 7584044}. 
# UCSC	uc003xbp	human. [Q15043-1]
# eggNOG	COG0428	LUCA
# eggNOG	KOG2693	Eukaryota
BLAST	swissprot:S39AE_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S39AE_HUMAN
BioCyc	ZFISH:ENSG00000104635-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000104635-MONOMER
COXPRESdb	23516	http://coxpresdb.jp/data/gene/23516.shtml
CleanEx	HS_SLC39A14	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC39A14
DOI	10.1016/S0005-2736(03)00048-8	http://dx.doi.org/10.1016/S0005-2736(03)00048-8
DOI	10.1016/j.febslet.2004.12.006	http://dx.doi.org/10.1016/j.febslet.2004.12.006
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/nature04406	http://dx.doi.org/10.1038/nature04406
DOI	10.1038/nbt.1532	http://dx.doi.org/10.1038/nbt.1532
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/dnares/1.5.223	http://dx.doi.org/10.1093/dnares/1.5.223
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AC087854	http://www.ebi.ac.uk/ena/data/view/AC087854
EMBL	AC105910	http://www.ebi.ac.uk/ena/data/view/AC105910
EMBL	AK172810	http://www.ebi.ac.uk/ena/data/view/AK172810
EMBL	AK295807	http://www.ebi.ac.uk/ena/data/view/AK295807
EMBL	BC015770	http://www.ebi.ac.uk/ena/data/view/BC015770
EMBL	CH471080	http://www.ebi.ac.uk/ena/data/view/CH471080
EMBL	CH471080	http://www.ebi.ac.uk/ena/data/view/CH471080
EMBL	CH471080	http://www.ebi.ac.uk/ena/data/view/CH471080
EMBL	D31887	http://www.ebi.ac.uk/ena/data/view/D31887
Ensembl	ENST00000240095	http://www.ensembl.org/id/ENST00000240095
Ensembl	ENST00000289952	http://www.ensembl.org/id/ENST00000289952
Ensembl	ENST00000359741	http://www.ensembl.org/id/ENST00000359741
Ensembl	ENST00000381237	http://www.ensembl.org/id/ENST00000381237
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030027	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030027
GO_function	GO:0005385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005385
GO_function	GO:0015093	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015093
GO_process	GO:0006882	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006882
GO_process	GO:0071577	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071577
GO_process	GO:0071578	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071578
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC39A14	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC39A14
GeneID	23516	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23516
GeneTree	ENSGT00760000119115	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119115
HGNC	HGNC:20858	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20858
HOGENOM	HOG000070225	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000070225&db=HOGENOM6
HOVERGEN	HBG108450	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108450&db=HOVERGEN
HPA	HPA016508	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA016508
InParanoid	Q15043	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q15043
IntAct	Q15043	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q15043*
InterPro	IPR003689	http://www.ebi.ac.uk/interpro/entry/IPR003689
Jabion	23516	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=23516
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:23516	http://www.genome.jp/dbget-bin/www_bget?hsa:23516
KEGG_Orthology	KO:K14720	http://www.genome.jp/dbget-bin/www_bget?KO:K14720
MIM	608736	http://www.ncbi.nlm.nih.gov/omim/608736
MINT	MINT-5004639	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5004639
OMA	CCCYLGM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CCCYLGM
OrthoDB	EOG091G064Y	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G064Y
PSORT	swissprot:S39AE_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S39AE_HUMAN
PSORT-B	swissprot:S39AE_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S39AE_HUMAN
PSORT2	swissprot:S39AE_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S39AE_HUMAN
Pfam	PF02535	http://pfam.xfam.org/family/PF02535
PharmGKB	PA134863701	http://www.pharmgkb.org/do/serve?objId=PA134863701&objCls=Gene
Phobius	swissprot:S39AE_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S39AE_HUMAN
PhylomeDB	Q15043	http://phylomedb.org/?seqid=Q15043
ProteinModelPortal	Q15043	http://www.proteinmodelportal.org/query/uniprot/Q15043
PubMed	12659941	http://www.ncbi.nlm.nih.gov/pubmed/12659941
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15642354	http://www.ncbi.nlm.nih.gov/pubmed/15642354
PubMed	16421571	http://www.ncbi.nlm.nih.gov/pubmed/16421571
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	19349973	http://www.ncbi.nlm.nih.gov/pubmed/19349973
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	7584044	http://www.ncbi.nlm.nih.gov/pubmed/7584044
Reactome	R-HSA-442380	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442380
RefSeq	NP_001121903	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001121903
RefSeq	NP_001128625	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001128625
RefSeq	NP_001128626	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001128626
RefSeq	NP_056174	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_056174
RefSeq	XP_005273522	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005273522
RefSeq	XP_005273523	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005273523
RefSeq	XP_006716387	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006716387
RefSeq	XP_011542780	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011542780
RefSeq	XP_016868783	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016868783
RefSeq	XP_016868784	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016868784
SMR	Q15043	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q15043
STRING	9606.ENSP00000289952	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000289952&targetmode=cogs
TCDB	2.A.5.4	http://www.tcdb.org/search/result.php?tc=2.A.5.4
UCSC	uc003xbp	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003xbp&org=rat
UniGene	Hs.491232	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.491232
UniProtKB	S39AE_HUMAN	http://www.uniprot.org/uniprot/S39AE_HUMAN
UniProtKB-AC	Q15043	http://www.uniprot.org/uniprot/Q15043
charge	swissprot:S39AE_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S39AE_HUMAN
eggNOG	COG0428	http://eggnogapi.embl.de/nog_data/html/tree/COG0428
eggNOG	KOG2693	http://eggnogapi.embl.de/nog_data/html/tree/KOG2693
epestfind	swissprot:S39AE_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S39AE_HUMAN
garnier	swissprot:S39AE_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S39AE_HUMAN
helixturnhelix	swissprot:S39AE_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S39AE_HUMAN
hmoment	swissprot:S39AE_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S39AE_HUMAN
iep	swissprot:S39AE_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S39AE_HUMAN
inforesidue	swissprot:S39AE_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S39AE_HUMAN
neXtProt	NX_Q15043	http://www.nextprot.org/db/entry/NX_Q15043
octanol	swissprot:S39AE_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S39AE_HUMAN
pepcoil	swissprot:S39AE_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S39AE_HUMAN
pepdigest	swissprot:S39AE_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S39AE_HUMAN
pepinfo	swissprot:S39AE_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S39AE_HUMAN
pepnet	swissprot:S39AE_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S39AE_HUMAN
pepstats	swissprot:S39AE_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S39AE_HUMAN
pepwheel	swissprot:S39AE_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S39AE_HUMAN
pepwindow	swissprot:S39AE_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S39AE_HUMAN
sigcleave	swissprot:S39AE_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S39AE_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CA2D1_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=Alpha-2a; IsoId=P54289-1; Sequence=Displayed; Name=2; Synonyms=Alpha-2b; IsoId=P54289-2; Sequence=VSP_038348, VSP_038350; Name=3; Synonyms=Alpha-2c; IsoId=P54289-3; Sequence=VSP_038349, VSP_038350; Name=4; Synonyms=Alpha-2d; IsoId=P54289-4; Sequence=VSP_038349; Name=5; Synonyms=Alpha-2e; IsoId=P54289-5; Sequence=VSP_038348; 
# AltName	CA2D1_HUMAN	Voltage-gated calcium channel subunit alpha-2/delta-1
# AltName	CA2D1_HUMAN	Voltage-gated calcium channel subunit alpha-2/delta-1
# BioGrid	107235	38
# CCDS	CCDS5598	-. [P54289-2]
# ChiTaRS	CACNA2D1	human
# DOMAIN	CA2D1_HUMAN	The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha- 1 (CACNA1) subunit to the plasma membrane by an integrin-like switch. {ECO 0000250}. 
# DrugBank	DB00270	Isradipine
# DrugBank	DB00308	Ibutilide
# DrugBank	DB00381	Amlodipine
# DrugBank	DB00401	Nisoldipine
# DrugBank	DB00421	Spironolactone
# DrugBank	DB00622	Nicardipine
# DrugBank	DB00653	Magnesium Sulfate
# DrugBank	DB00996	Gabapentin
# DrugBank	DB01023	Felodipine
# DrugBank	DB01054	Nitrendipine
# DrugBank	DB01115	Nifedipine
# DrugBank	DB04838	Cyclandelate
# DrugBank	DB06712	Nilvadipine
# Ensembl	ENST00000356253	ENSP00000348589; ENSG00000153956. [P54289-1]
# Ensembl	ENST00000356860	ENSP00000349320; ENSG00000153956. [P54289-2]
# ExpressionAtlas	P54289	baseline and differential
# FUNCTION	CA2D1_HUMAN	The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity). {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005891	voltage-gated calcium channel complex; IDA:UniProtKB.
# GO_component	GO:0016529	sarcoplasmic reticulum; IEA:Ensembl.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_component	GO:1990454	L-type voltage-gated calcium channel complex; IDA:BHF-UCL.
# GO_function	GO:0005245	voltage-gated calcium channel activity; IDA:BHF-UCL.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0006816	calcium ion transport; IDA:UniProtKB.
# GO_process	GO:0051924	regulation of calcium ion transport; IDA:BHF-UCL.
# GO_process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization; IMP:BHF-UCL.
# GO_process	GO:0060402	calcium ion transport into cytosol; ISS:BHF-UCL.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:0061577	calcium ion transmembrane transport via high voltage-gated calcium channel; ISS:BHF-UCL.
# GO_process	GO:0086002	cardiac muscle cell action potential involved in contraction; IMP:BHF-UCL.
# GO_process	GO:0086012	membrane depolarization during cardiac muscle cell action potential; IEA:GOC.
# GO_process	GO:0086091	regulation of heart rate by cardiac conduction; IMP:BHF-UCL.
# GO_process	GO:0098903	regulation of membrane repolarization during action potential; ISS:BHF-UCL.
# GO_process	GO:1901843	positive regulation of high voltage-gated calcium channel activity; ISS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.410	-; 1.
# Genevisible	P54289	HS
# HGNC	HGNC:1399	CACNA2D1
# IntAct	P54289	8
# InterPro	IPR002035	VWF_A
# InterPro	IPR013608	VWA_N
# InterPro	IPR013680	VDCC_a2/dsu
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04010	MAPK signaling pathway
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05410	Hypertrophic cardiomyopathy (HCM)
# KEGG_Pathway	ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
# KEGG_Pathway	ko05414	Dilated cardiomyopathy
# MIM	114204	gene
# MISCELLANEOUS	CA2D1_HUMAN	Binds gabapentin, an antiepileptic drug. 
# Organism	CA2D1_HUMAN	Homo sapiens (Human)
# Orphanet	130	Brugada syndrome
# Orphanet	51083	Familial short QT syndrome
# PIR	JH0565	JH0565
# PROSITE	PS50234	VWFA
# PTM	CA2D1_HUMAN	Proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked. {ECO 0000250}. 
# Pfam	PF00092	VWA
# Pfam	PF08399	VWA_N
# Pfam	PF08473	VGCC_alpha2
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# Reactome	R-HSA-5576893	Phase 2 - plateau phase
# Reactome	R-HSA-5576894	Phase 1 - inactivation of fast Na+ channels
# RecName	CA2D1_HUMAN	Voltage-dependent calcium channel subunit alpha-2-1
# RecName	CA2D1_HUMAN	Voltage-dependent calcium channel subunit alpha-2-1
# RecName	CA2D1_HUMAN	Voltage-dependent calcium channel subunit alpha-2/delta-1
# RecName	CA2D1_HUMAN	Voltage-dependent calcium channel subunit delta-1
# RefSeq	NP_000713	NM_000722.3. [P54289-2]
# RefSeq	XP_005250627	XM_005250570.2. [P54289-1]
# RefSeq	XP_005250629	XM_005250572.2. [P54289-3]
# RefSeq	XP_005250630	XM_005250573.2. [P54289-5]
# RefSeq	XP_005250631	XM_005250574.2. [P54289-4]
# SIMILARITY	Belongs to the calcium channel subunit alpha-2/delta family. {ECO	0000305}. 
# SIMILARITY	Contains 1 VWFA domain. {ECO:0000255|PROSITE- ProRule	PRU00219}.
# SIMILARITY	Contains 1 cache domain. {ECO	0000305}. 
# SMART	SM00327	VWA
# SUBCELLULAR LOCATION	CA2D1_HUMAN	Membrane {ECO 0000305}; Single-pass type I membrane protein {ECO 0000305}. 
# SUBUNIT	CA2D1_HUMAN	Dimer formed of alpha-2-1 and delta-1 chains; disulfide- linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1 1 1 1 ratio (By similarity). {ECO 0000250}. 
# SUPFAM	SSF53300	SSF53300
# TCDB	8.A.18.1	the ca(2+) channel auxiliary subunit Alpha2Delta types 1-4 (cca-Alpha2Delta) family
# TISSUE SPECIFICITY	CA2D1_HUMAN	Isoform 1 is expressed in skeletal muscle. Isoform 2 is expressed in the central nervous system. Isoform 2, isoform 4 and isoform 5 are expressed in neuroblastoma cells. Isoform 3, isoform 4 and isoform 5 are expressed in the aorta. {ECO 0000269|PubMed 1309651, ECO 0000269|PubMed 8107964}. 
# UCSC	uc003uhr	human. [P54289-1]
# eggNOG	ENOG410XPDX	LUCA
# eggNOG	KOG2353	Eukaryota
BLAST	swissprot:CA2D1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CA2D1_HUMAN
BioCyc	ZFISH:ENSG00000153956-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000153956-MONOMER
COXPRESdb	781	http://coxpresdb.jp/data/gene/781.shtml
CleanEx	HS_CACNA2D1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CACNA2D1
DOI	10.1016/0028-3908(93)90004-M	http://dx.doi.org/10.1016/0028-3908(93)90004-M
DOI	10.1016/0896-6273(92)90109-Q	http://dx.doi.org/10.1016/0896-6273(92)90109-Q
DOI	10.1016/j.ceca.2011.10.002	http://dx.doi.org/10.1016/j.ceca.2011.10.002
DOI	10.1021/pr0502065	http://dx.doi.org/10.1021/pr0502065
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00270	http://www.drugbank.ca/drugs/DB00270
DrugBank	DB00308	http://www.drugbank.ca/drugs/DB00308
DrugBank	DB00381	http://www.drugbank.ca/drugs/DB00381
DrugBank	DB00401	http://www.drugbank.ca/drugs/DB00401
DrugBank	DB00421	http://www.drugbank.ca/drugs/DB00421
DrugBank	DB00622	http://www.drugbank.ca/drugs/DB00622
DrugBank	DB00653	http://www.drugbank.ca/drugs/DB00653
DrugBank	DB00996	http://www.drugbank.ca/drugs/DB00996
DrugBank	DB01023	http://www.drugbank.ca/drugs/DB01023
DrugBank	DB01054	http://www.drugbank.ca/drugs/DB01054
DrugBank	DB01115	http://www.drugbank.ca/drugs/DB01115
DrugBank	DB04838	http://www.drugbank.ca/drugs/DB04838
DrugBank	DB06712	http://www.drugbank.ca/drugs/DB06712
EMBL	BC117468	http://www.ebi.ac.uk/ena/data/view/BC117468
EMBL	BC117470	http://www.ebi.ac.uk/ena/data/view/BC117470
EMBL	CH471091	http://www.ebi.ac.uk/ena/data/view/CH471091
EMBL	M76559	http://www.ebi.ac.uk/ena/data/view/M76559
Ensembl	ENST00000356253	http://www.ensembl.org/id/ENST00000356253
Ensembl	ENST00000356860	http://www.ensembl.org/id/ENST00000356860
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005891
GO_component	GO:0016529	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016529
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_component	GO:1990454	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990454
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0051924	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051924
GO_process	GO:0060307	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060307
GO_process	GO:0060402	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060402
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:0061577	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061577
GO_process	GO:0086002	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086002
GO_process	GO:0086012	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086012
GO_process	GO:0086091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086091
GO_process	GO:0098903	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098903
GO_process	GO:1901843	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901843
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.410	http://www.cathdb.info/version/latest/superfamily/3.40.50.410
GeneCards	CACNA2D1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CACNA2D1
GeneID	781	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=781
GeneTree	ENSGT00530000062904	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062904
HGNC	HGNC:1399	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1399
HOVERGEN	HBG057779	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG057779&db=HOVERGEN
HPA	HPA008213	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA008213
HPA	HPA008621	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA008621
InParanoid	P54289	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P54289
IntAct	P54289	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P54289*
InterPro	IPR002035	http://www.ebi.ac.uk/interpro/entry/IPR002035
InterPro	IPR013608	http://www.ebi.ac.uk/interpro/entry/IPR013608
InterPro	IPR013680	http://www.ebi.ac.uk/interpro/entry/IPR013680
Jabion	781	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=781
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:781	http://www.genome.jp/dbget-bin/www_bget?hsa:781
KEGG_Orthology	KO:K04858	http://www.genome.jp/dbget-bin/www_bget?KO:K04858
KEGG_Pathway	ko04010	http://www.genome.jp/kegg-bin/show_pathway?ko04010
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05410	http://www.genome.jp/kegg-bin/show_pathway?ko05410
KEGG_Pathway	ko05412	http://www.genome.jp/kegg-bin/show_pathway?ko05412
KEGG_Pathway	ko05414	http://www.genome.jp/kegg-bin/show_pathway?ko05414
MIM	114204	http://www.ncbi.nlm.nih.gov/omim/114204
OMA	DDYTNQI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DDYTNQI
Orphanet	130	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=130
Orphanet	51083	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=51083
OrthoDB	EOG091G00UY	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00UY
PROSITE	PS50234	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50234
PSORT	swissprot:CA2D1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CA2D1_HUMAN
PSORT-B	swissprot:CA2D1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CA2D1_HUMAN
PSORT2	swissprot:CA2D1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CA2D1_HUMAN
Pfam	PF00092	http://pfam.xfam.org/family/PF00092
Pfam	PF08399	http://pfam.xfam.org/family/PF08399
Pfam	PF08473	http://pfam.xfam.org/family/PF08473
PharmGKB	PA86	http://www.pharmgkb.org/do/serve?objId=PA86&objCls=Gene
Phobius	swissprot:CA2D1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CA2D1_HUMAN
PhylomeDB	P54289	http://phylomedb.org/?seqid=P54289
ProteinModelPortal	P54289	http://www.proteinmodelportal.org/query/uniprot/P54289
PubMed	1309651	http://www.ncbi.nlm.nih.gov/pubmed/1309651
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16335952	http://www.ncbi.nlm.nih.gov/pubmed/16335952
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	22054663	http://www.ncbi.nlm.nih.gov/pubmed/22054663
PubMed	8107964	http://www.ncbi.nlm.nih.gov/pubmed/8107964
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
Reactome	R-HSA-5576893	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576893
Reactome	R-HSA-5576894	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576894
RefSeq	NP_000713	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000713
RefSeq	XP_005250627	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005250627
RefSeq	XP_005250629	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005250629
RefSeq	XP_005250630	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005250630
RefSeq	XP_005250631	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005250631
SMART	SM00327	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00327
STRING	9606.ENSP00000349320	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000349320&targetmode=cogs
SUPFAM	SSF53300	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53300
TCDB	8.A.18.1	http://www.tcdb.org/search/result.php?tc=8.A.18.1
UCSC	uc003uhr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003uhr&org=rat
UniGene	Hs.282151	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.282151
UniGene	Hs.592625	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.592625
UniGene	Hs.743228	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.743228
UniProtKB	CA2D1_HUMAN	http://www.uniprot.org/uniprot/CA2D1_HUMAN
UniProtKB-AC	P54289	http://www.uniprot.org/uniprot/P54289
charge	swissprot:CA2D1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CA2D1_HUMAN
eggNOG	ENOG410XPDX	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPDX
eggNOG	KOG2353	http://eggnogapi.embl.de/nog_data/html/tree/KOG2353
epestfind	swissprot:CA2D1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CA2D1_HUMAN
garnier	swissprot:CA2D1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CA2D1_HUMAN
helixturnhelix	swissprot:CA2D1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CA2D1_HUMAN
hmoment	swissprot:CA2D1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CA2D1_HUMAN
iep	swissprot:CA2D1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CA2D1_HUMAN
inforesidue	swissprot:CA2D1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CA2D1_HUMAN
neXtProt	NX_P54289	http://www.nextprot.org/db/entry/NX_P54289
octanol	swissprot:CA2D1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CA2D1_HUMAN
pepcoil	swissprot:CA2D1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CA2D1_HUMAN
pepdigest	swissprot:CA2D1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CA2D1_HUMAN
pepinfo	swissprot:CA2D1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CA2D1_HUMAN
pepnet	swissprot:CA2D1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CA2D1_HUMAN
pepstats	swissprot:CA2D1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CA2D1_HUMAN
pepwheel	swissprot:CA2D1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CA2D1_HUMAN
pepwindow	swissprot:CA2D1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CA2D1_HUMAN
sigcleave	swissprot:CA2D1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CA2D1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S22AC_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q96S37-1; Sequence=Displayed; Name=2; IsoId=Q96S37-2; Sequence=VSP_028879; Name=3; IsoId=Q96S37-3; Sequence=VSP_054054; Name=4; IsoId=Q96S37-4; Sequence=VSP_054055; 
# AltName	S22AC_HUMAN	Organic anion transporter 4-like protein
# AltName	S22AC_HUMAN	Renal-specific transporter
# AltName	S22AC_HUMAN	Urate anion exchanger 1
# BioGrid	125471	4
# CCDS	CCDS60835	-. [Q96S37-4]
# CCDS	CCDS60836	-. [Q96S37-2]
# CCDS	CCDS8075	-. [Q96S37-1]
# CDD	cd06174	MFS
# DISEASE	S22AC_HUMAN	Hypouricemia renal 1 (RHUC1) [MIM 220150]  A disorder characterized by impaired uric acid reabsorption at the apical membrane of proximal renal tubule cells, and high urinary urate excretion. Patients often appear asymptomatic, but may be subject to exercise-induced acute renal failure, chronic renal dysfunction and nephrolithiasis. {ECO 0000269|PubMed 12024214, ECO 0000269|PubMed 14694169, ECO 0000269|PubMed 15327384, ECO 0000269|PubMed 15634722, ECO 0000269|PubMed 15912381, ECO 0000269|PubMed 16837472, ECO 0000269|PubMed 26418379}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00678	Losartan
# DrugBank	DB01032	Probenecid
# Ensembl	ENST00000336464	ENSP00000336836; ENSG00000197891. [Q96S37-4]
# Ensembl	ENST00000377567	ENSP00000366790; ENSG00000197891. [Q96S37-2]
# Ensembl	ENST00000377572	ENSP00000366795; ENSG00000197891. [Q96S37-2]
# Ensembl	ENST00000377574	ENSP00000366797; ENSG00000197891. [Q96S37-1]
# Ensembl	ENST00000473690	ENSP00000438437; ENSG00000197891. [Q96S37-3]
# FUNCTION	S22AC_HUMAN	Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions. {ECO 0000269|PubMed 12024214}. 
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IDA:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_component	GO:0031526	brush border membrane; ISS:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005452	inorganic anion exchanger activity; IBA:GO_Central.
# GO_function	GO:0015143	urate transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015347	sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0030165	PDZ domain binding; IPI:UniProtKB.
# GO_process	GO:0015747	urate transport; IDA:UniProtKB.
# GO_process	GO:0019725	cellular homeostasis; NAS:UniProtKB.
# GO_process	GO:0042493	response to drug; IDA:UniProtKB.
# GO_process	GO:0043252	sodium-independent organic anion transport; IBA:GO_Central.
# GO_process	GO:0046415	urate metabolic process; IMP:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044281	small molecule metabolic process
# Genevisible	Q96S37	HS
# HGNC	HGNC:17989	SLC22A12
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H00948	[Urinary system disease] Renal hypouricemia (RHUC)
# MIM	220150	phenotype
# MIM	607096	gene
# Organism	S22AC_HUMAN	Homo sapiens (Human)
# Orphanet	94088	Hereditary renal hypouricemia
# PROSITE	PS50850	MFS
# Pfam	PF00083	Sugar_tr
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-561048	Organic anion transport
# RecName	S22AC_HUMAN	Solute carrier family 22 member 12
# RefSeq	NP_001263255	NM_001276326.1. [Q96S37-4]
# RefSeq	NP_001263256	NM_001276327.1. [Q96S37-2]
# RefSeq	NP_653186	NM_144585.3. [Q96S37-1]
# RefSeq	NP_700357	NM_153378.2. [Q96S37-3]
# SEQUENCE CAUTION	Sequence=BAB68364.1; Type=Frameshift; Positions=84, 136; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S22AC_HUMAN	Cell membrane {ECO 0000269|PubMed 12024214}; Multi-pass membrane protein {ECO 0000269|PubMed 12024214}. Note=Detected in the luminal membrane of the epithelium of renal proximal tubules. 
# SUBUNIT	S22AC_HUMAN	Interacts with PDZK1. {ECO 0000269|PubMed 14531806, ECO 0000269|PubMed 15304510}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.19.11	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	S22AC_HUMAN	Detected in kidney (at protein level). Detected in fetal and adult kidney. Detected in epithelial cells of proximal tubules in renal cortex. {ECO 0000269|PubMed 12024214, ECO 0000269|PubMed 15304510}. 
# UCSC	uc001oal	human. [Q96S37-1]
# eggNOG	COG0477	LUCA
# eggNOG	KOG0255	Eukaryota
BLAST	swissprot:S22AC_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S22AC_HUMAN
BioCyc	ZFISH:ENSG00000171239-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000171239-MONOMER
COXPRESdb	116085	http://coxpresdb.jp/data/gene/116085.shtml
CleanEx	HS_SLC22A12	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC22A12
DOI	10.1002/art.21499	http://dx.doi.org/10.1002/art.21499
DOI	10.1007/s00467-005-1863-3	http://dx.doi.org/10.1007/s00467-005-1863-3
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1038/nature742	http://dx.doi.org/10.1038/nature742
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1046/j.1523-1755.2003.00266.x	http://dx.doi.org/10.1046/j.1523-1755.2003.00266.x
DOI	10.1074/jbc.M406724200	http://dx.doi.org/10.1074/jbc.M406724200
DOI	10.1093/rheumatology/kel205	http://dx.doi.org/10.1093/rheumatology/kel205
DOI	10.1097/01.ASN.0000105320.04395.D0	http://dx.doi.org/10.1097/01.ASN.0000105320.04395.D0
DOI	10.1097/MAJ.0000000000000550	http://dx.doi.org/10.1097/MAJ.0000000000000550
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1523-1755.2004.00839.x	http://dx.doi.org/10.1111/j.1523-1755.2004.00839.x
DOI	10.1210/jc.2004-1111	http://dx.doi.org/10.1210/jc.2004-1111
DrugBank	DB00678	http://www.drugbank.ca/drugs/DB00678
DrugBank	DB01032	http://www.drugbank.ca/drugs/DB01032
EMBL	AB050269	http://www.ebi.ac.uk/ena/data/view/AB050269
EMBL	AB071863	http://www.ebi.ac.uk/ena/data/view/AB071863
EMBL	AC044790	http://www.ebi.ac.uk/ena/data/view/AC044790
EMBL	AK315061	http://www.ebi.ac.uk/ena/data/view/AK315061
EMBL	AP001092	http://www.ebi.ac.uk/ena/data/view/AP001092
EMBL	AY358183	http://www.ebi.ac.uk/ena/data/view/AY358183
EMBL	BC053348	http://www.ebi.ac.uk/ena/data/view/BC053348
EMBL	CH471076	http://www.ebi.ac.uk/ena/data/view/CH471076
EMBL	CH471076	http://www.ebi.ac.uk/ena/data/view/CH471076
EMBL	DQ514593	http://www.ebi.ac.uk/ena/data/view/DQ514593
EMBL	DQ514594	http://www.ebi.ac.uk/ena/data/view/DQ514594
EMBL	DQ514595	http://www.ebi.ac.uk/ena/data/view/DQ514595
EMBL	DQ514596	http://www.ebi.ac.uk/ena/data/view/DQ514596
Ensembl	ENST00000336464	http://www.ensembl.org/id/ENST00000336464
Ensembl	ENST00000377567	http://www.ensembl.org/id/ENST00000377567
Ensembl	ENST00000377572	http://www.ensembl.org/id/ENST00000377572
Ensembl	ENST00000377574	http://www.ensembl.org/id/ENST00000377574
Ensembl	ENST00000473690	http://www.ensembl.org/id/ENST00000473690
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0031526	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031526
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005452	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005452
GO_function	GO:0015143	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015143
GO_function	GO:0015347	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015347
GO_function	GO:0030165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030165
GO_process	GO:0015747	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015747
GO_process	GO:0019725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019725
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0043252	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043252
GO_process	GO:0046415	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046415
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GeneCards	SLC22A12	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC22A12
GeneID	116085	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=116085
GeneTree	ENSGT00760000118852	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118852
HGNC	HGNC:17989	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17989
HOVERGEN	HBG108433	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108433&db=HOVERGEN
HPA	HPA024575	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA024575
InParanoid	Q96S37	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96S37
IntAct	Q96S37	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96S37*
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	116085	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=116085
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00948	http://www.genome.jp/dbget-bin/www_bget?H00948
KEGG_Gene	hsa:116085	http://www.genome.jp/dbget-bin/www_bget?hsa:116085
KEGG_Orthology	KO:K08208	http://www.genome.jp/dbget-bin/www_bget?KO:K08208
MIM	220150	http://www.ncbi.nlm.nih.gov/omim/220150
MIM	607096	http://www.ncbi.nlm.nih.gov/omim/607096
OMA	VRDWTLL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VRDWTLL
Orphanet	94088	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=94088
OrthoDB	EOG091G068G	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G068G
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:S22AC_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S22AC_HUMAN
PSORT-B	swissprot:S22AC_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S22AC_HUMAN
PSORT2	swissprot:S22AC_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S22AC_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
PharmGKB	PA38478	http://www.pharmgkb.org/do/serve?objId=PA38478&objCls=Gene
Phobius	swissprot:S22AC_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S22AC_HUMAN
PhylomeDB	Q96S37	http://phylomedb.org/?seqid=Q96S37
ProteinModelPortal	Q96S37	http://www.proteinmodelportal.org/query/uniprot/Q96S37
PubMed	12024214	http://www.ncbi.nlm.nih.gov/pubmed/12024214
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	14531806	http://www.ncbi.nlm.nih.gov/pubmed/14531806
PubMed	14694169	http://www.ncbi.nlm.nih.gov/pubmed/14694169
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15304510	http://www.ncbi.nlm.nih.gov/pubmed/15304510
PubMed	15327384	http://www.ncbi.nlm.nih.gov/pubmed/15327384
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15634722	http://www.ncbi.nlm.nih.gov/pubmed/15634722
PubMed	15912381	http://www.ncbi.nlm.nih.gov/pubmed/15912381
PubMed	16385546	http://www.ncbi.nlm.nih.gov/pubmed/16385546
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	16837472	http://www.ncbi.nlm.nih.gov/pubmed/16837472
PubMed	26418379	http://www.ncbi.nlm.nih.gov/pubmed/26418379
Reactome	R-HSA-561048	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-561048
RefSeq	NP_001263255	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001263255
RefSeq	NP_001263256	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001263256
RefSeq	NP_653186	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_653186
RefSeq	NP_700357	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_700357
STRING	9606.ENSP00000366797	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000366797&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.19.11	http://www.tcdb.org/search/result.php?tc=2.A.1.19.11
UCSC	uc001oal	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001oal&org=rat
UniGene	Hs.174424	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.174424
UniGene	Hs.700182	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.700182
UniProtKB	S22AC_HUMAN	http://www.uniprot.org/uniprot/S22AC_HUMAN
UniProtKB-AC	Q96S37	http://www.uniprot.org/uniprot/Q96S37
charge	swissprot:S22AC_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S22AC_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG0255	http://eggnogapi.embl.de/nog_data/html/tree/KOG0255
epestfind	swissprot:S22AC_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S22AC_HUMAN
garnier	swissprot:S22AC_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S22AC_HUMAN
helixturnhelix	swissprot:S22AC_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S22AC_HUMAN
hmoment	swissprot:S22AC_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S22AC_HUMAN
iep	swissprot:S22AC_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S22AC_HUMAN
inforesidue	swissprot:S22AC_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S22AC_HUMAN
neXtProt	NX_Q96S37	http://www.nextprot.org/db/entry/NX_Q96S37
octanol	swissprot:S22AC_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S22AC_HUMAN
pepcoil	swissprot:S22AC_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S22AC_HUMAN
pepdigest	swissprot:S22AC_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S22AC_HUMAN
pepinfo	swissprot:S22AC_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S22AC_HUMAN
pepnet	swissprot:S22AC_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S22AC_HUMAN
pepstats	swissprot:S22AC_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S22AC_HUMAN
pepwheel	swissprot:S22AC_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S22AC_HUMAN
pepwindow	swissprot:S22AC_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S22AC_HUMAN
sigcleave	swissprot:S22AC_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S22AC_HUMAN
## Database	ID	URL or Descriptions
# AltName	SL9A5_HUMAN	Na(+)/H(+) exchanger 5
# AltName	SL9A5_HUMAN	Solute carrier family 9 member 5
# BioGrid	112442	5
# CAUTION	The number, localization and denomination of hydrophobic domains in the Na(+)/H(+) exchangers vary among authors. {ECO	0000305}.
# Ensembl	ENST00000299798	ENSP00000299798; ENSG00000135740
# ExpressionAtlas	Q14940	baseline and differential
# FUNCTION	SL9A5_HUMAN	Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity). {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_function	SL9A5_HUMAN	GO 0015385 sodium proton antiporter activity; TAS Reactome.
# GO_function	SL9A5_HUMAN	GO 0015386 potassium proton antiporter activity; IBA GO_Central.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0051453	regulation of intracellular pH; IBA:GO_Central.
# GO_process	GO:0071805	potassium ion transmembrane transport; IBA:GO_Central.
# GO_process	GO:0098719	sodium ion import across plasma membrane; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q14940	HS
# HGNC	HGNC:11078	SLC9A5
# InterPro	IPR004709	NaH_exchanger
# InterPro	IPR006153	Cation/H_exchanger
# InterPro	IPR018410	Na/H_exchanger_3/5
# InterPro	IPR018422	Cation/H_exchanger_CPA1
# KEGG_Brite	ko02001	Solute carrier family
# MIM	600477	gene
# Organism	SL9A5_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10110	PTHR10110; 3
# PRINTS	PR01084	NAHEXCHNGR
# PRINTS	PR01087	NAHEXCHNGR3
# PTM	SL9A5_HUMAN	Phosphorylated (Possible). 
# Pfam	PF00999	Na_H_Exchanger
# Proteomes	UP000005640	Chromosome 16
# Reactome	R-HSA-425986	Sodium/Proton exchangers
# RecName	SL9A5_HUMAN	Sodium/hydrogen exchanger 5
# RefSeq	NP_004585	NM_004594.2
# SIMILARITY	Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	SL9A5_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Interacts with CHP1 and CHP2 (By similarity). Interacts with ARRB2. {ECO:0000250, ECO	0000269|PubMed:15699339}. 
# TCDB	2.A.36.1.16:the monovalent cation	proton antiporter-1 (cpa1) family
# TIGRFAMs	TIGR00840	b_cpa1
# TISSUE SPECIFICITY	SL9A5_HUMAN	Expressed in brain, testis, spleen, and skeletal muscle. 
# UCSC	uc002esm	human
# eggNOG	COG0025	LUCA
# eggNOG	KOG1966	Eukaryota
BLAST	swissprot:SL9A5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SL9A5_HUMAN
BioCyc	ZFISH:ENSG00000135740-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000135740-MONOMER
COXPRESdb	6553	http://coxpresdb.jp/data/gene/6553.shtml
CleanEx	HS_SLC9A5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC9A5
DOI	10.1016/0888-7543(95)80002-4	http://dx.doi.org/10.1016/0888-7543(95)80002-4
DOI	10.1073/pnas.0407444102	http://dx.doi.org/10.1073/pnas.0407444102
DOI	10.1074/jbc.274.7.4377	http://dx.doi.org/10.1074/jbc.274.7.4377
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF111173	http://www.ebi.ac.uk/ena/data/view/AF111173
EMBL	BC142671	http://www.ebi.ac.uk/ena/data/view/BC142671
EMBL	CH471092	http://www.ebi.ac.uk/ena/data/view/CH471092
EMBL	U08607	http://www.ebi.ac.uk/ena/data/view/U08607
Ensembl	ENST00000299798	http://www.ensembl.org/id/ENST00000299798
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015385
GO_function	GO:0015386	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015386
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GO_process	GO:0098719	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098719
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC9A5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC9A5
GeneID	6553	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6553
GeneTree	ENSGT00760000119074	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119074
HGNC	HGNC:11078	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11078
HOGENOM	HOG000247044	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000247044&db=HOGENOM6
HOVERGEN	HBG052615	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052615&db=HOVERGEN
HPA	HPA041004	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA041004
HPA	HPA041329	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA041329
InParanoid	Q14940	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q14940
IntAct	Q14940	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q14940*
InterPro	IPR004709	http://www.ebi.ac.uk/interpro/entry/IPR004709
InterPro	IPR006153	http://www.ebi.ac.uk/interpro/entry/IPR006153
InterPro	IPR018410	http://www.ebi.ac.uk/interpro/entry/IPR018410
InterPro	IPR018422	http://www.ebi.ac.uk/interpro/entry/IPR018422
Jabion	6553	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6553
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6553	http://www.genome.jp/dbget-bin/www_bget?hsa:6553
KEGG_Orthology	KO:K14723	http://www.genome.jp/dbget-bin/www_bget?KO:K14723
MIM	600477	http://www.ncbi.nlm.nih.gov/omim/600477
OMA	IPQQQEL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IPQQQEL
OrthoDB	EOG091G02Q0	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02Q0
PANTHER	PTHR10110	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10110
PRINTS	PR01084	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01084
PRINTS	PR01087	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01087
PSORT	swissprot:SL9A5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SL9A5_HUMAN
PSORT-B	swissprot:SL9A5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SL9A5_HUMAN
PSORT2	swissprot:SL9A5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SL9A5_HUMAN
Pfam	PF00999	http://pfam.xfam.org/family/PF00999
PharmGKB	PA35934	http://www.pharmgkb.org/do/serve?objId=PA35934&objCls=Gene
Phobius	swissprot:SL9A5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SL9A5_HUMAN
PhylomeDB	Q14940	http://phylomedb.org/?seqid=Q14940
ProteinModelPortal	Q14940	http://www.proteinmodelportal.org/query/uniprot/Q14940
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15699339	http://www.ncbi.nlm.nih.gov/pubmed/15699339
PubMed	7759094	http://www.ncbi.nlm.nih.gov/pubmed/7759094
PubMed	9933641	http://www.ncbi.nlm.nih.gov/pubmed/9933641
Reactome	R-HSA-425986	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425986
RefSeq	NP_004585	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004585
SMR	Q14940	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q14940
STRING	9606.ENSP00000299798	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000299798&targetmode=cogs
TCDB	2.A.36.1.16	http://www.tcdb.org/search/result.php?tc=2.A.36.1.16
TIGRFAMs	TIGR00840	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00840
UCSC	uc002esm	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002esm&org=rat
UniGene	Hs.439650	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.439650
UniProtKB	SL9A5_HUMAN	http://www.uniprot.org/uniprot/SL9A5_HUMAN
UniProtKB-AC	Q14940	http://www.uniprot.org/uniprot/Q14940
charge	swissprot:SL9A5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SL9A5_HUMAN
eggNOG	COG0025	http://eggnogapi.embl.de/nog_data/html/tree/COG0025
eggNOG	KOG1966	http://eggnogapi.embl.de/nog_data/html/tree/KOG1966
epestfind	swissprot:SL9A5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SL9A5_HUMAN
garnier	swissprot:SL9A5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SL9A5_HUMAN
helixturnhelix	swissprot:SL9A5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SL9A5_HUMAN
hmoment	swissprot:SL9A5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SL9A5_HUMAN
iep	swissprot:SL9A5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SL9A5_HUMAN
inforesidue	swissprot:SL9A5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SL9A5_HUMAN
neXtProt	NX_Q14940	http://www.nextprot.org/db/entry/NX_Q14940
octanol	swissprot:SL9A5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SL9A5_HUMAN
pepcoil	swissprot:SL9A5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SL9A5_HUMAN
pepdigest	swissprot:SL9A5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SL9A5_HUMAN
pepinfo	swissprot:SL9A5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SL9A5_HUMAN
pepnet	swissprot:SL9A5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SL9A5_HUMAN
pepstats	swissprot:SL9A5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SL9A5_HUMAN
pepwheel	swissprot:SL9A5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SL9A5_HUMAN
pepwindow	swissprot:SL9A5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SL9A5_HUMAN
sigcleave	swissprot:SL9A5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SL9A5_HUMAN
## Database	ID	URL or Descriptions
# AltName	CLIC1_HUMAN	Chloride channel ABP
# AltName	CLIC1_HUMAN	Nuclear chloride ion channel 27
# AltName	CLIC1_HUMAN	Regulatory nuclear chloride ion channel protein
# BioGrid	107604	56
# ChiTaRS	CLIC1	human
# DOMAIN	CLIC1_HUMAN	Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion. {ECO 0000269|PubMed 14613939, ECO 0000269|PubMed 18850721}. 
# Ensembl	ENST00000375779	ENSP00000364934; ENSG00000213719
# Ensembl	ENST00000375780	ENSP00000364935; ENSG00000213719
# Ensembl	ENST00000375784	ENSP00000364940; ENSG00000213719
# Ensembl	ENST00000383404	ENSP00000372896; ENSG00000206394
# Ensembl	ENST00000383405	ENSP00000372897; ENSG00000206394
# Ensembl	ENST00000395892	ENSP00000379229; ENSG00000213719
# Ensembl	ENST00000400052	ENSP00000382926; ENSG00000206394
# Ensembl	ENST00000400058	ENSP00000382931; ENSG00000206394
# Ensembl	ENST00000415179	ENSP00000409247; ENSG00000226248
# Ensembl	ENST00000418285	ENSP00000407791; ENSG00000226417
# Ensembl	ENST00000420458	ENSP00000410965; ENSG00000226651
# Ensembl	ENST00000422167	ENSP00000407429; ENSG00000226248
# Ensembl	ENST00000423055	ENSP00000406968; ENSG00000226417
# Ensembl	ENST00000423143	ENSP00000404589; ENSG00000223639
# Ensembl	ENST00000423804	ENSP00000409979; ENSG00000230685
# Ensembl	ENST00000425464	ENSP00000401292; ENSG00000223639
# Ensembl	ENST00000431921	ENSP00000408357; ENSG00000226248
# Ensembl	ENST00000433916	ENSP00000391395; ENSG00000226651
# Ensembl	ENST00000434202	ENSP00000400532; ENSG00000226651
# Ensembl	ENST00000435242	ENSP00000412217; ENSG00000226417
# Ensembl	ENST00000438708	ENSP00000406088; ENSG00000226248
# Ensembl	ENST00000438750	ENSP00000404037; ENSG00000223639
# Ensembl	ENST00000442045	ENSP00000400280; ENSG00000226417
# Ensembl	ENST00000447338	ENSP00000413330; ENSG00000230685
# Ensembl	ENST00000447369	ENSP00000408094; ENSG00000230685
# Ensembl	ENST00000451546	ENSP00000416211; ENSG00000223639
# Ensembl	ENST00000456863	ENSP00000406335; ENSG00000226651
# Ensembl	ENST00000457485	ENSP00000398056; ENSG00000230685
# Ensembl	ENST00000614673	ENSP00000480256; ENSG00000230685
# Ensembl	ENST00000614982	ENSP00000477623; ENSG00000206394
# Ensembl	ENST00000616760	ENSP00000479808; ENSG00000213719
# Ensembl	ENST00000618288	ENSP00000479501; ENSG00000226417
# Ensembl	ENST00000619727	ENSP00000482255; ENSG00000226651
# Ensembl	ENST00000621055	ENSP00000478930; ENSG00000226248
# Ensembl	ENST00000622613	ENSP00000484581; ENSG00000223639
# ExpressionAtlas	O00299	baseline and differential
# FUNCTION	CLIC1_HUMAN	Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle. {ECO 0000269|PubMed 10834939, ECO 0000269|PubMed 11195932, ECO 0000269|PubMed 11551966, ECO 0000269|PubMed 11940526, ECO 0000269|PubMed 11978800, ECO 0000269|PubMed 14613939, ECO 0000269|PubMed 9139710}. 
# GO_component	GO:0005615	extracellular space; IDA:UniProtKB.
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005635	nuclear envelope; IDA:MGI.
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005739	mitochondrion; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005903	brush border; TAS:UniProtKB.
# GO_component	GO:0005913	cell-cell adherens junction; IDA:BHF-UCL.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0031965	nuclear membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0031982	vesicle; IDA:UniProtKB.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IDA:BHF-UCL.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_component	GO:0072562	blood microparticle; IDA:UniProtKB.
# GO_function	GO:0005244	voltage-gated ion channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0005254	chloride channel activity; IDA:MGI.
# GO_function	GO:0098641	cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
# GO_process	GO:0006821	chloride transport; IDA:MGI.
# GO_process	GO:0007165	signal transduction; TAS:UniProtKB.
# GO_process	GO:0045669	positive regulation of osteoblast differentiation; IEA:Ensembl.
# GO_process	GO:0051726	regulation of cell cycle; IEA:InterPro.
# GO_process	GO:0051881	regulation of mitochondrial membrane potential; IEA:Ensembl.
# GO_process	GO:0070527	platelet aggregation; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005615	extracellular space
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005635	nuclear envelope
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007155	cell adhesion
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.20.1050.10	-; 1.
# Gene3D	3.40.30.10	-; 1.
# Genevisible	O00299	HS
# HGNC	HGNC:2062	CLIC1
# IntAct	O00299	42
# InterPro	IPR002946	CLIC
# InterPro	IPR004045	Glutathione_S-Trfase_N
# InterPro	IPR010987	Glutathione-S-Trfase_C-like
# InterPro	IPR012336	Thioredoxin-like_fold
# InterPro	IPR030259	CLIC-1
# KEGG_Brite	ko04040	Ion channels
# MIM	602872	gene
# MISCELLANEOUS	CLIC1_HUMAN	The protein seems to have very low affinity for glutathione, even though glutathione binding was observed in protein crystals. 
# Organism	CLIC1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11260:SF210	PTHR11260:SF210; 2
# PDB	1K0M	X-ray; 1.40 A; A/B=1-241
# PDB	1K0N	X-ray; 1.80 A; A/B=1-241
# PDB	1K0O	X-ray; 1.75 A; A/B=1-241
# PDB	1RK4	X-ray; 1.79 A; A/B=1-241
# PDB	3O3T	X-ray; 1.70 A; A=1-241
# PDB	3P8W	X-ray; 2.00 A; A=1-241
# PDB	3P90	X-ray; 2.30 A; A=1-241
# PDB	3QR6	X-ray; 1.78 A; A=1-241
# PDB	3SWL	X-ray; 2.35 A; A=6-241
# PDB	3TGZ	X-ray; 2.30 A; A/B=1-241
# PDB	3UVH	X-ray; 1.84 A; A/B=1-241
# PDB	4IQA	X-ray; 2.49 A; A/B=6-241
# PDB	4JZQ	X-ray; 1.35 A; A/B=1-241
# PDB	4K0G	X-ray; 1.40 A; A=2-241
# PDB	4K0N	X-ray; 1.25 A; A=1-241
# PRINTS	PR01263	INTCLCHANNEL
# PROSITE	PS50405	GST_CTER
# PTM	CLIC1_HUMAN	Hydrogen peroxide treatment causes a conformation change, leading to dimerization and formation of an intramolecular disulfide bond between Cys-24 and Cys-59. 
# Pfam	PF13409	GST_N_2
# Proteomes	UP000005640	Chromosome 6
# RecName	CLIC1_HUMAN	Chloride intracellular channel protein 1
# RefSeq	NP_001274522	NM_001287593.1
# RefSeq	NP_001274523	NM_001287594.1
# RefSeq	NP_001279	NM_001288.4
# SIMILARITY	Belongs to the chloride channel CLIC family. {ECO	0000305}. 
# SIMILARITY	Contains 1 GST C-terminal domain. {ECO	0000305}. 
# SUBCELLULAR LOCATION	CLIC1_HUMAN	Nucleus. Nucleus membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. Cytoplasm. Cell membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. Note=Mostly in the nucleus including in the nuclear membrane. Small amount in the cytoplasm and the plasma membrane. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. 
# SUBUNIT	CLIC1_HUMAN	Monomer. Homodimer (in vitro). Interacts with TRAPPC2. Dimerization requires a conformation change that leads to the exposure of a large hydrophobic surface. In vivo, this may lead to membrane insertion. Interacts with AKAP9. {ECO 0000269|PubMed 11551966, ECO 0000269|PubMed 12163479, ECO 0000269|PubMed 12681486, ECO 0000269|PubMed 14613939}. 
# SUPFAM	SSF47616	SSF47616
# SUPFAM	SSF52833	SSF52833
# TCDB	1.A.12.1	the intracellular chloride channel (clic) family
# TIGRFAMs	TIGR00862	O-ClC
# TISSUE SPECIFICITY	Expression is prominent in heart, placenta, liver, kidney and pancreas. {ECO:0000269|PubMed	10793131}. 
# WEB RESOURCE	CLIC1_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/CLIC1ID50543ch6p21.html";
# eggNOG	ENOG410INGZ	Eukaryota
# eggNOG	ENOG410ZZZX	LUCA
BLAST	swissprot:CLIC1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CLIC1_HUMAN
BioCyc	ZFISH:ENSG00000096238-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000096238-MONOMER
COXPRESdb	1192	http://coxpresdb.jp/data/gene/1192.shtml
CleanEx	HS_CLIC1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CLIC1
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/S0014-5793(03)00228-X	http://dx.doi.org/10.1016/S0014-5793(03)00228-X
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/bi801147r	http://dx.doi.org/10.1021/bi801147r
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1074/jbc.272.19.12575	http://dx.doi.org/10.1074/jbc.272.19.12575
DOI	10.1074/jbc.M107804200	http://dx.doi.org/10.1074/jbc.M107804200
DOI	10.1074/jbc.M112277200	http://dx.doi.org/10.1074/jbc.M112277200
DOI	10.1074/jbc.M203666200	http://dx.doi.org/10.1074/jbc.M203666200
DOI	10.1074/jbc.M308444200	http://dx.doi.org/10.1074/jbc.M308444200
DOI	10.1074/mcp.M111.015131	http://dx.doi.org/10.1074/mcp.M111.015131
DOI	10.1091/mbc.11.5.1509	http://dx.doi.org/10.1091/mbc.11.5.1509
DOI	10.1101/gr.1736803	http://dx.doi.org/10.1101/gr.1736803
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1469-7793.2000.00541.x	http://dx.doi.org/10.1111/j.1469-7793.2000.00541.x
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1152/ajpcell.00402.2001	http://dx.doi.org/10.1152/ajpcell.00402.2001
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF034607	http://www.ebi.ac.uk/ena/data/view/AF034607
EMBL	AF109197	http://www.ebi.ac.uk/ena/data/view/AF109197
EMBL	AF129756	http://www.ebi.ac.uk/ena/data/view/AF129756
EMBL	AJ012008	http://www.ebi.ac.uk/ena/data/view/AJ012008
EMBL	AL662899	http://www.ebi.ac.uk/ena/data/view/AL662899
EMBL	BA000025	http://www.ebi.ac.uk/ena/data/view/BA000025
EMBL	BC064527	http://www.ebi.ac.uk/ena/data/view/BC064527
EMBL	BC095469	http://www.ebi.ac.uk/ena/data/view/BC095469
EMBL	CR542071	http://www.ebi.ac.uk/ena/data/view/CR542071
EMBL	U93205	http://www.ebi.ac.uk/ena/data/view/U93205
EMBL	X87689	http://www.ebi.ac.uk/ena/data/view/X87689
Ensembl	ENST00000375779	http://www.ensembl.org/id/ENST00000375779
Ensembl	ENST00000375780	http://www.ensembl.org/id/ENST00000375780
Ensembl	ENST00000375784	http://www.ensembl.org/id/ENST00000375784
Ensembl	ENST00000383404	http://www.ensembl.org/id/ENST00000383404
Ensembl	ENST00000383405	http://www.ensembl.org/id/ENST00000383405
Ensembl	ENST00000395892	http://www.ensembl.org/id/ENST00000395892
Ensembl	ENST00000400052	http://www.ensembl.org/id/ENST00000400052
Ensembl	ENST00000400058	http://www.ensembl.org/id/ENST00000400058
Ensembl	ENST00000415179	http://www.ensembl.org/id/ENST00000415179
Ensembl	ENST00000418285	http://www.ensembl.org/id/ENST00000418285
Ensembl	ENST00000420458	http://www.ensembl.org/id/ENST00000420458
Ensembl	ENST00000422167	http://www.ensembl.org/id/ENST00000422167
Ensembl	ENST00000423055	http://www.ensembl.org/id/ENST00000423055
Ensembl	ENST00000423143	http://www.ensembl.org/id/ENST00000423143
Ensembl	ENST00000423804	http://www.ensembl.org/id/ENST00000423804
Ensembl	ENST00000425464	http://www.ensembl.org/id/ENST00000425464
Ensembl	ENST00000431921	http://www.ensembl.org/id/ENST00000431921
Ensembl	ENST00000433916	http://www.ensembl.org/id/ENST00000433916
Ensembl	ENST00000434202	http://www.ensembl.org/id/ENST00000434202
Ensembl	ENST00000435242	http://www.ensembl.org/id/ENST00000435242
Ensembl	ENST00000438708	http://www.ensembl.org/id/ENST00000438708
Ensembl	ENST00000438750	http://www.ensembl.org/id/ENST00000438750
Ensembl	ENST00000442045	http://www.ensembl.org/id/ENST00000442045
Ensembl	ENST00000447338	http://www.ensembl.org/id/ENST00000447338
Ensembl	ENST00000447369	http://www.ensembl.org/id/ENST00000447369
Ensembl	ENST00000451546	http://www.ensembl.org/id/ENST00000451546
Ensembl	ENST00000456863	http://www.ensembl.org/id/ENST00000456863
Ensembl	ENST00000457485	http://www.ensembl.org/id/ENST00000457485
Ensembl	ENST00000614673	http://www.ensembl.org/id/ENST00000614673
Ensembl	ENST00000614982	http://www.ensembl.org/id/ENST00000614982
Ensembl	ENST00000616760	http://www.ensembl.org/id/ENST00000616760
Ensembl	ENST00000618288	http://www.ensembl.org/id/ENST00000618288
Ensembl	ENST00000619727	http://www.ensembl.org/id/ENST00000619727
Ensembl	ENST00000621055	http://www.ensembl.org/id/ENST00000621055
Ensembl	ENST00000622613	http://www.ensembl.org/id/ENST00000622613
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005615
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005903	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005903
GO_component	GO:0005913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005913
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0031965	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031965
GO_component	GO:0031982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031982
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_component	GO:0072562	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072562
GO_function	GO:0005244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005244
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0098641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098641
GO_process	GO:0006821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006821
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0045669	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045669
GO_process	GO:0051726	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051726
GO_process	GO:0051881	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051881
GO_process	GO:0070527	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070527
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005615
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.20.1050.10	http://www.cathdb.info/version/latest/superfamily/1.20.1050.10
Gene3D	3.40.30.10	http://www.cathdb.info/version/latest/superfamily/3.40.30.10
GeneCards	CLIC1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CLIC1
GeneID	1192	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1192
GeneTree	ENSGT00550000074477	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074477
HGNC	HGNC:2062	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2062
HOGENOM	HOG000231548	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231548&db=HOGENOM6
HOVERGEN	HBG050994	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050994&db=HOVERGEN
HPA	CAB020825	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB020825
HPA	CAB040557	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB040557
InParanoid	O00299	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O00299
IntAct	O00299	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O00299*
InterPro	IPR002946	http://www.ebi.ac.uk/interpro/entry/IPR002946
InterPro	IPR004045	http://www.ebi.ac.uk/interpro/entry/IPR004045
InterPro	IPR010987	http://www.ebi.ac.uk/interpro/entry/IPR010987
InterPro	IPR012336	http://www.ebi.ac.uk/interpro/entry/IPR012336
InterPro	IPR030259	http://www.ebi.ac.uk/interpro/entry/IPR030259
Jabion	1192	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1192
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:1192	http://www.genome.jp/dbget-bin/www_bget?hsa:1192
KEGG_Orthology	KO:K05021	http://www.genome.jp/dbget-bin/www_bget?KO:K05021
MIM	602872	http://www.ncbi.nlm.nih.gov/omim/602872
MINT	MINT-1033423	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1033423
OMA	VCLKYRS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VCLKYRS
OrthoDB	EOG091G0IHT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0IHT
PANTHER	PTHR11260:SF210	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11260:SF210
PDB	1K0M	http://www.ebi.ac.uk/pdbe-srv/view/entry/1K0M
PDB	1K0N	http://www.ebi.ac.uk/pdbe-srv/view/entry/1K0N
PDB	1K0O	http://www.ebi.ac.uk/pdbe-srv/view/entry/1K0O
PDB	1RK4	http://www.ebi.ac.uk/pdbe-srv/view/entry/1RK4
PDB	3O3T	http://www.ebi.ac.uk/pdbe-srv/view/entry/3O3T
PDB	3P8W	http://www.ebi.ac.uk/pdbe-srv/view/entry/3P8W
PDB	3P90	http://www.ebi.ac.uk/pdbe-srv/view/entry/3P90
PDB	3QR6	http://www.ebi.ac.uk/pdbe-srv/view/entry/3QR6
PDB	3SWL	http://www.ebi.ac.uk/pdbe-srv/view/entry/3SWL
PDB	3TGZ	http://www.ebi.ac.uk/pdbe-srv/view/entry/3TGZ
PDB	3UVH	http://www.ebi.ac.uk/pdbe-srv/view/entry/3UVH
PDB	4IQA	http://www.ebi.ac.uk/pdbe-srv/view/entry/4IQA
PDB	4JZQ	http://www.ebi.ac.uk/pdbe-srv/view/entry/4JZQ
PDB	4K0G	http://www.ebi.ac.uk/pdbe-srv/view/entry/4K0G
PDB	4K0N	http://www.ebi.ac.uk/pdbe-srv/view/entry/4K0N
PDBsum	1K0M	http://www.ebi.ac.uk/pdbsum/1K0M
PDBsum	1K0N	http://www.ebi.ac.uk/pdbsum/1K0N
PDBsum	1K0O	http://www.ebi.ac.uk/pdbsum/1K0O
PDBsum	1RK4	http://www.ebi.ac.uk/pdbsum/1RK4
PDBsum	3O3T	http://www.ebi.ac.uk/pdbsum/3O3T
PDBsum	3P8W	http://www.ebi.ac.uk/pdbsum/3P8W
PDBsum	3P90	http://www.ebi.ac.uk/pdbsum/3P90
PDBsum	3QR6	http://www.ebi.ac.uk/pdbsum/3QR6
PDBsum	3SWL	http://www.ebi.ac.uk/pdbsum/3SWL
PDBsum	3TGZ	http://www.ebi.ac.uk/pdbsum/3TGZ
PDBsum	3UVH	http://www.ebi.ac.uk/pdbsum/3UVH
PDBsum	4IQA	http://www.ebi.ac.uk/pdbsum/4IQA
PDBsum	4JZQ	http://www.ebi.ac.uk/pdbsum/4JZQ
PDBsum	4K0G	http://www.ebi.ac.uk/pdbsum/4K0G
PDBsum	4K0N	http://www.ebi.ac.uk/pdbsum/4K0N
PRINTS	PR01263	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01263
PROSITE	PS50405	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50405
PSORT	swissprot:CLIC1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CLIC1_HUMAN
PSORT-B	swissprot:CLIC1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CLIC1_HUMAN
PSORT2	swissprot:CLIC1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CLIC1_HUMAN
Pfam	PF13409	http://pfam.xfam.org/family/PF13409
PharmGKB	PA26588	http://www.pharmgkb.org/do/serve?objId=PA26588&objCls=Gene
Phobius	swissprot:CLIC1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CLIC1_HUMAN
PhylomeDB	O00299	http://phylomedb.org/?seqid=O00299
ProteinModelPortal	O00299	http://www.proteinmodelportal.org/query/uniprot/O00299
PubMed	10191309	http://www.ncbi.nlm.nih.gov/pubmed/10191309
PubMed	10384126	http://www.ncbi.nlm.nih.gov/pubmed/10384126
PubMed	10793131	http://www.ncbi.nlm.nih.gov/pubmed/10793131
PubMed	10834939	http://www.ncbi.nlm.nih.gov/pubmed/10834939
PubMed	11195932	http://www.ncbi.nlm.nih.gov/pubmed/11195932
PubMed	11551966	http://www.ncbi.nlm.nih.gov/pubmed/11551966
PubMed	11940526	http://www.ncbi.nlm.nih.gov/pubmed/11940526
PubMed	11978800	http://www.ncbi.nlm.nih.gov/pubmed/11978800
PubMed	12163479	http://www.ncbi.nlm.nih.gov/pubmed/12163479
PubMed	12681486	http://www.ncbi.nlm.nih.gov/pubmed/12681486
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14613939	http://www.ncbi.nlm.nih.gov/pubmed/14613939
PubMed	14656967	http://www.ncbi.nlm.nih.gov/pubmed/14656967
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18850721	http://www.ncbi.nlm.nih.gov/pubmed/18850721
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22223895	http://www.ncbi.nlm.nih.gov/pubmed/22223895
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	9139710	http://www.ncbi.nlm.nih.gov/pubmed/9139710
RefSeq	NP_001274522	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001274522
RefSeq	NP_001274523	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001274523
RefSeq	NP_001279	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001279
SMR	O00299	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O00299
STRING	9606.ENSP00000364934	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000364934&targetmode=cogs
SUPFAM	SSF47616	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47616
SUPFAM	SSF52833	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833
SWISS-2DPAGE	O00299	http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=O00299
TCDB	1.A.12.1	http://www.tcdb.org/search/result.php?tc=1.A.12.1
TIGRFAMs	TIGR00862	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00862
UniGene	Hs.414565	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.414565
UniProtKB	CLIC1_HUMAN	http://www.uniprot.org/uniprot/CLIC1_HUMAN
UniProtKB-AC	O00299	http://www.uniprot.org/uniprot/O00299
charge	swissprot:CLIC1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CLIC1_HUMAN
eggNOG	ENOG410INGZ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410INGZ
eggNOG	ENOG410ZZZX	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZZZX
epestfind	swissprot:CLIC1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CLIC1_HUMAN
garnier	swissprot:CLIC1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CLIC1_HUMAN
helixturnhelix	swissprot:CLIC1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLIC1_HUMAN
hmoment	swissprot:CLIC1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CLIC1_HUMAN
iep	swissprot:CLIC1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CLIC1_HUMAN
inforesidue	swissprot:CLIC1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CLIC1_HUMAN
neXtProt	NX_O00299	http://www.nextprot.org/db/entry/NX_O00299
octanol	swissprot:CLIC1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CLIC1_HUMAN
pepcoil	swissprot:CLIC1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CLIC1_HUMAN
pepdigest	swissprot:CLIC1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CLIC1_HUMAN
pepinfo	swissprot:CLIC1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CLIC1_HUMAN
pepnet	swissprot:CLIC1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CLIC1_HUMAN
pepstats	swissprot:CLIC1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CLIC1_HUMAN
pepwheel	swissprot:CLIC1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CLIC1_HUMAN
pepwindow	swissprot:CLIC1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CLIC1_HUMAN
sigcleave	swissprot:CLIC1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CLIC1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SL9A3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P48764-1; Sequence=Displayed; Name=2; IsoId=P48764-2; Sequence=VSP_053989; Note=No experimental confirmation available.; 
# AltName	Na(+)/H(+) exchanger 3 {ECO:0000303|PubMed	7631746}
# AltName	SL9A3_HUMAN	Solute carrier family 9 member 3
# BioGrid	112440	9
# CAUTION	The number, localization and denomination of hydrophobic domains in the Na(+)/H(+) exchangers vary among authors. {ECO	0000305}.
# CCDS	CCDS3855	-. [P48764-1]
# CCDS	CCDS64116	-. [P48764-2]
# DISEASE	SL9A3_HUMAN	Diarrhea 8, secretory sodium, congenital (DIAR8) [MIM 616868]  A disease characterized by watery secretory diarrhea with prenatal onset, prominent abdominal distension after birth due to dilated fluid-filled loops of intestine, elevated fecal sodium concentrations and low urinary sodium concentrations. {ECO 0000269|PubMed 26358773}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000264938	ENSP00000264938; ENSG00000066230. [P48764-1]
# Ensembl	ENST00000514375	ENSP00000422983; ENSG00000066230. [P48764-2]
# FUNCTION	SL9A3_HUMAN	Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient (PubMed 26358773). Plays an important role in signal transduction. {ECO 0000269|PubMed 26358773}. 
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005903	brush border; ISS:UniProtKB.
# GO_component	GO:0009986	cell surface; ISS:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0016324	apical plasma membrane; ISS:UniProtKB.
# GO_component	GO:0031526	brush border membrane; ISS:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0030165	PDZ domain binding; ISS:UniProtKB.
# GO_function	SL9A3_HUMAN	GO 0015385 sodium proton antiporter activity; IDA UniProtKB.
# GO_function	SL9A3_HUMAN	GO 0015386 potassium proton antiporter activity; IBA GO_Central.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0051453	regulation of intracellular pH; IBA:GO_Central.
# GO_process	GO:0071805	potassium ion transmembrane transport; IBA:GO_Central.
# GO_process	GO:0098719	sodium ion import across plasma membrane; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P48764	HS
# HGNC	HGNC:11073	SLC9A3
# INTERACTION	SL9A3_HUMAN	Q6P0Q8 MAST2; NbExp=2; IntAct=EBI-7816923, EBI-493777; 
# InterPro	IPR004709	NaH_exchanger
# InterPro	IPR006153	Cation/H_exchanger
# InterPro	IPR018410	Na/H_exchanger_3/5
# InterPro	IPR018422	Cation/H_exchanger_CPA1
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04964	Proximal tubule bicarbonate reclamation
# KEGG_Pathway	ko04974	Protein digestion and absorption
# KEGG_Pathway	ko04976	Bile secretion
# KEGG_Pathway	ko04978	Mineral absorption
# MIM	182307	gene
# MIM	616868	phenotype
# Organism	SL9A3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10110	PTHR10110; 2
# PIR	B40205	B40205
# PRINTS	PR01084	NAHEXCHNGR
# PRINTS	PR01087	NAHEXCHNGR3
# PTM	SL9A3_HUMAN	Phosphorylated by PKA, which inhibits activity. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane. {ECO 0000250|UniProtKB P26432, ECO 0000250|UniProtKB P26433}. 
# Pfam	PF00999	Na_H_Exchanger
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-425986	Sodium/Proton exchangers
# RecName	Sodium/hydrogen exchanger 3 {ECO	0000305}
# RefSeq	NP_001271280	NM_001284351.2. [P48764-2]
# RefSeq	NP_004165	NM_004174.3. [P48764-1]
# SIMILARITY	Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	SL9A3_HUMAN	Apical cell membrane {ECO 0000269|PubMed 19088451, ECO 0000269|PubMed 26358773}; Multi- pass membrane protein {ECO 0000269|PubMed 19088451}. Note=In intestinal epithelial cells, localizes to the ileal brush border. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane. Angiotensin-2 enhances apical expression (By similarity). {ECO 0000250|UniProtKB Q28362}. 
# SUBUNIT	SL9A3_HUMAN	Binds SLC9A3R1 and SLC9A3R2. Interacts with CHP1, CHP2 and SHANK2. Interacts with PDZK1 (via C-terminal PDZ domain) (By similarity). Interacts with PDZD3 and interactions decrease in response to elevated calcium ion levels. Interacts with AHCYL1; the interaction is required for SLC9A3 activity (PubMed 18829453, PubMed 20584908). {ECO 0000250|UniProtKB P26432, ECO 0000250|UniProtKB P26433, ECO 0000250|UniProtKB Q28362, ECO 0000269|PubMed 18829453, ECO 0000269|PubMed 19088451, ECO 0000269|PubMed 20584908}. 
# TCDB	2.A.36.1.15:the monovalent cation	proton antiporter-1 (cpa1) family
# TIGRFAMs	TIGR00840	b_cpa1
# UCSC	uc003jbe	human. [P48764-1]
# eggNOG	COG0025	LUCA
# eggNOG	KOG1966	Eukaryota
BLAST	swissprot:SL9A3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SL9A3_HUMAN
BioCyc	ZFISH:ENSG00000066230-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000066230-MONOMER
COXPRESdb	6550	http://coxpresdb.jp/data/gene/6550.shtml
CleanEx	HS_SLC9A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC9A3
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1074/jbc.M110.133066	http://dx.doi.org/10.1074/jbc.M110.133066
DOI	10.1074/jbc.M805534200	http://dx.doi.org/10.1074/jbc.M805534200
DOI	10.1093/hmg/ddv367	http://dx.doi.org/10.1093/hmg/ddv367
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1159/000185553	http://dx.doi.org/10.1159/000185553
EMBL	AC010442	http://www.ebi.ac.uk/ena/data/view/AC010442
EMBL	AC106772	http://www.ebi.ac.uk/ena/data/view/AC106772
EMBL	BC101669	http://www.ebi.ac.uk/ena/data/view/BC101669
EMBL	BC101671	http://www.ebi.ac.uk/ena/data/view/BC101671
EMBL	BC143328	http://www.ebi.ac.uk/ena/data/view/BC143328
EMBL	U28043	http://www.ebi.ac.uk/ena/data/view/U28043
Ensembl	ENST00000264938	http://www.ensembl.org/id/ENST00000264938
Ensembl	ENST00000514375	http://www.ensembl.org/id/ENST00000514375
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005903	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005903
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0031526	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031526
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0015385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015385
GO_function	GO:0015386	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015386
GO_function	GO:0030165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030165
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GO_process	GO:0098719	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098719
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC9A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC9A3
GeneID	6550	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6550
GeneTree	ENSGT00760000119074	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119074
H-InvDB	HIX0004707	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0004707
H-InvDB	HIX0032039	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0032039
HGNC	HGNC:11073	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11073
HOGENOM	HOG000247044	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000247044&db=HOGENOM6
HOVERGEN	HBG052615	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052615&db=HOVERGEN
HPA	HPA036493	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA036493
HPA	HPA036669	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA036669
InParanoid	P48764	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P48764
IntAct	P48764	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P48764*
InterPro	IPR004709	http://www.ebi.ac.uk/interpro/entry/IPR004709
InterPro	IPR006153	http://www.ebi.ac.uk/interpro/entry/IPR006153
InterPro	IPR018410	http://www.ebi.ac.uk/interpro/entry/IPR018410
InterPro	IPR018422	http://www.ebi.ac.uk/interpro/entry/IPR018422
Jabion	6550	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6550
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6550	http://www.genome.jp/dbget-bin/www_bget?hsa:6550
KEGG_Orthology	KO:K12040	http://www.genome.jp/dbget-bin/www_bget?KO:K12040
KEGG_Pathway	ko04964	http://www.genome.jp/kegg-bin/show_pathway?ko04964
KEGG_Pathway	ko04974	http://www.genome.jp/kegg-bin/show_pathway?ko04974
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
KEGG_Pathway	ko04978	http://www.genome.jp/kegg-bin/show_pathway?ko04978
MIM	182307	http://www.ncbi.nlm.nih.gov/omim/182307
MIM	616868	http://www.ncbi.nlm.nih.gov/omim/616868
MINT	MINT-1787470	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1787470
OMA	YTMKMLA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YTMKMLA
OrthoDB	EOG091G02Q0	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02Q0
PANTHER	PTHR10110	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10110
PRINTS	PR01084	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01084
PRINTS	PR01087	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01087
PSORT	swissprot:SL9A3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SL9A3_HUMAN
PSORT-B	swissprot:SL9A3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SL9A3_HUMAN
PSORT2	swissprot:SL9A3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SL9A3_HUMAN
Pfam	PF00999	http://pfam.xfam.org/family/PF00999
PharmGKB	PA316	http://www.pharmgkb.org/do/serve?objId=PA316&objCls=Gene
Phobius	swissprot:SL9A3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SL9A3_HUMAN
PhylomeDB	P48764	http://phylomedb.org/?seqid=P48764
ProteinModelPortal	P48764	http://www.proteinmodelportal.org/query/uniprot/P48764
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18829453	http://www.ncbi.nlm.nih.gov/pubmed/18829453
PubMed	19088451	http://www.ncbi.nlm.nih.gov/pubmed/19088451
PubMed	20584908	http://www.ncbi.nlm.nih.gov/pubmed/20584908
PubMed	26358773	http://www.ncbi.nlm.nih.gov/pubmed/26358773
PubMed	7631746	http://www.ncbi.nlm.nih.gov/pubmed/7631746
Reactome	R-HSA-425986	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425986
RefSeq	NP_001271280	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001271280
RefSeq	NP_004165	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004165
SMR	P48764	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P48764
STRING	9606.ENSP00000264938	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000264938&targetmode=cogs
TCDB	2.A.36.1.15	http://www.tcdb.org/search/result.php?tc=2.A.36.1.15
TIGRFAMs	TIGR00840	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00840
UCSC	uc003jbe	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003jbe&org=rat
UniGene	Hs.658120	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.658120
UniProtKB	SL9A3_HUMAN	http://www.uniprot.org/uniprot/SL9A3_HUMAN
UniProtKB-AC	P48764	http://www.uniprot.org/uniprot/P48764
charge	swissprot:SL9A3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SL9A3_HUMAN
eggNOG	COG0025	http://eggnogapi.embl.de/nog_data/html/tree/COG0025
eggNOG	KOG1966	http://eggnogapi.embl.de/nog_data/html/tree/KOG1966
epestfind	swissprot:SL9A3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SL9A3_HUMAN
garnier	swissprot:SL9A3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SL9A3_HUMAN
helixturnhelix	swissprot:SL9A3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SL9A3_HUMAN
hmoment	swissprot:SL9A3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SL9A3_HUMAN
iep	swissprot:SL9A3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SL9A3_HUMAN
inforesidue	swissprot:SL9A3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SL9A3_HUMAN
neXtProt	NX_P48764	http://www.nextprot.org/db/entry/NX_P48764
octanol	swissprot:SL9A3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SL9A3_HUMAN
pepcoil	swissprot:SL9A3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SL9A3_HUMAN
pepdigest	swissprot:SL9A3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SL9A3_HUMAN
pepinfo	swissprot:SL9A3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SL9A3_HUMAN
pepnet	swissprot:SL9A3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SL9A3_HUMAN
pepstats	swissprot:SL9A3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SL9A3_HUMAN
pepwheel	swissprot:SL9A3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SL9A3_HUMAN
pepwindow	swissprot:SL9A3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SL9A3_HUMAN
sigcleave	swissprot:SL9A3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SL9A3_HUMAN
## Database	ID	URL or Descriptions
# AltName	S22AI_HUMAN	Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein
# AltName	S22AI_HUMAN	Efflux transporter-like protein
# AltName	S22AI_HUMAN	Imprinted multi-membrane-spanning polyspecific transporter-related protein 1
# AltName	S22AI_HUMAN	Organic cation transporter-like protein 2
# AltName	S22AI_HUMAN	Solute carrier family 22 member 1-like
# AltName	S22AI_HUMAN	Tumor-suppressing STF cDNA 5 protein
# AltName	S22AI_HUMAN	Tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein
# AltName	S22AI_HUMAN	p45-Beckwith-Wiedemann region 1 A
# BioGrid	111044	26
# CAUTION	It is uncertain whether Met-1 or Met-17 is the initiator. {ECO	0000305}. 
# CDD	cd06174	MFS
# DISEASE	S22AI_HUMAN	Lung cancer (LNCR) [MIM 211980]  A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes  squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. {ECO 0000269|PubMed 9751628}. Note=The gene represented in this entry may be involved in disease pathogenesis. 
# DISEASE	S22AI_HUMAN	Rhabdomyosarcoma, embryonal, 1 (RMSE1) [MIM 268210]  A form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchymal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms  alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas. Note=The disease may be caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000312221	ENSP00000311139; ENSG00000110628
# Ensembl	ENST00000347936	ENSP00000307859; ENSG00000110628
# Ensembl	ENST00000380574	ENSP00000369948; ENSG00000110628
# ExpressionAtlas	Q96BI1	baseline and differential
# FUNCTION	S22AI_HUMAN	May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. {ECO 0000269|PubMed 9744804}. 
# GO_component	GO:0005635	nuclear envelope; IDA:UniProtKB.
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_function	GO:0015238	drug transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_function	GO:0031625	ubiquitin protein ligase binding; IPI:UniProtKB.
# GO_function	S22AI_HUMAN	GO 0015307 drug proton antiporter activity; TAS Reactome.
# GO_process	GO:0007588	excretion; NAS:UniProtKB.
# GO_process	GO:0015695	organic cation transport; NAS:UniProtKB.
# GO_process	GO:0015893	drug transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005635	nuclear envelope
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q96BI1	HS
# HGNC	HGNC:10964	SLC22A18
# IntAct	Q96BI1	4
# InterPro	IPR001958	Tet-R_TetA/multi-R_MdtG
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	114480	phenotype
# MIM	211980	phenotype
# MIM	268210	phenotype
# MIM	602631	gene
# Organism	S22AI_HUMAN	Homo sapiens (Human)
# PRINTS	PR01035	TCRTETA
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-549127	Organic cation transport
# RecName	S22AI_HUMAN	Solute carrier family 22 member 18
# RefSeq	NP_001302430	NM_001315501.1
# RefSeq	NP_001302431	NM_001315502.1
# RefSeq	NP_002546	NM_002555.5
# RefSeq	NP_899056	NM_183233.2
# SEQUENCE CAUTION	Sequence=AAB82727.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA32779.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S22AI_HUMAN	Apical cell membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. Note=Localized at the apical membrane surface of renal proximal tubules. {ECO 0000269|PubMed 9744804}. 
# SUBUNIT	Interacts with RNF167. {ECO:0000269|PubMed	16314844}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.2.53	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	S22AI_HUMAN	Expressed at high levels in adult and fetal kidney and liver, and adult colon. Expressed in fetal renal proximal tubules (at protein level). Expressed at lower levels in heart, brain and lung. {ECO 0000269|PubMed 9499412, ECO 0000269|PubMed 9520460, ECO 0000269|PubMed 9570947, ECO 0000269|PubMed 9744804}. 
# UCSC	uc001lwx	human
# eggNOG	ENOG410IIP5	Eukaryota
# eggNOG	ENOG4111F2C	LUCA
BLAST	swissprot:S22AI_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S22AI_HUMAN
BioCyc	ZFISH:ENSG00000110628-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000110628-MONOMER
COXPRESdb	5002	http://coxpresdb.jp/data/gene/5002.shtml
CleanEx	HS_SLC22A18	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC22A18
DOI	10.1006/geno.1998.5221	http://dx.doi.org/10.1006/geno.1998.5221
DOI	10.1016/S0014-5793(98)00907-7	http://dx.doi.org/10.1016/S0014-5793(98)00907-7
DOI	10.1038/sj.onc.1209167	http://dx.doi.org/10.1038/sj.onc.1209167
DOI	10.1073/pnas.95.7.3873	http://dx.doi.org/10.1073/pnas.95.7.3873
DOI	10.1093/dnares/5.4.235	http://dx.doi.org/10.1093/dnares/5.4.235
DOI	10.1093/hmg/7.4.597	http://dx.doi.org/10.1093/hmg/7.4.597
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB012083	http://www.ebi.ac.uk/ena/data/view/AB012083
EMBL	AF028738	http://www.ebi.ac.uk/ena/data/view/AF028738
EMBL	AF030302	http://www.ebi.ac.uk/ena/data/view/AF030302
EMBL	AF037064	http://www.ebi.ac.uk/ena/data/view/AF037064
EMBL	AF059663	http://www.ebi.ac.uk/ena/data/view/AF059663
EMBL	AF070479	http://www.ebi.ac.uk/ena/data/view/AF070479
EMBL	BC015571	http://www.ebi.ac.uk/ena/data/view/BC015571
Ensembl	ENST00000312221	http://www.ensembl.org/id/ENST00000312221
Ensembl	ENST00000347936	http://www.ensembl.org/id/ENST00000347936
Ensembl	ENST00000380574	http://www.ensembl.org/id/ENST00000380574
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_function	GO:0015238	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015238
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_function	GO:0015307	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015307
GO_function	GO:0031625	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031625
GO_process	GO:0007588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007588
GO_process	GO:0015695	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015695
GO_process	GO:0015893	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015893
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	SLC22A18	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC22A18
GeneID	5002	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5002
GeneTree	ENSGT00830000128359	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00830000128359
H-InvDB	HIX0019391	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0019391
HGNC	HGNC:10964	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10964
HOVERGEN	HBG082086	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG082086&db=HOVERGEN
InParanoid	Q96BI1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96BI1
IntAct	Q96BI1	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96BI1*
InterPro	IPR001958	http://www.ebi.ac.uk/interpro/entry/IPR001958
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	5002	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=5002
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:5002	http://www.genome.jp/dbget-bin/www_bget?hsa:5002
KEGG_Orthology	KO:K08214	http://www.genome.jp/dbget-bin/www_bget?KO:K08214
MIM	114480	http://www.ncbi.nlm.nih.gov/omim/114480
MIM	211980	http://www.ncbi.nlm.nih.gov/omim/211980
MIM	268210	http://www.ncbi.nlm.nih.gov/omim/268210
MIM	602631	http://www.ncbi.nlm.nih.gov/omim/602631
OMA	LMWPSFL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LMWPSFL
OrthoDB	EOG091G0H3E	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0H3E
PRINTS	PR01035	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01035
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:S22AI_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S22AI_HUMAN
PSORT-B	swissprot:S22AI_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S22AI_HUMAN
PSORT2	swissprot:S22AI_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S22AI_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA35846	http://www.pharmgkb.org/do/serve?objId=PA35846&objCls=Gene
Phobius	swissprot:S22AI_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S22AI_HUMAN
PhylomeDB	Q96BI1	http://phylomedb.org/?seqid=Q96BI1
ProteinModelPortal	Q96BI1	http://www.proteinmodelportal.org/query/uniprot/Q96BI1
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16314844	http://www.ncbi.nlm.nih.gov/pubmed/16314844
PubMed	9499412	http://www.ncbi.nlm.nih.gov/pubmed/9499412
PubMed	9520460	http://www.ncbi.nlm.nih.gov/pubmed/9520460
PubMed	9570947	http://www.ncbi.nlm.nih.gov/pubmed/9570947
PubMed	9744804	http://www.ncbi.nlm.nih.gov/pubmed/9744804
PubMed	9751628	http://www.ncbi.nlm.nih.gov/pubmed/9751628
PubMed	9802569	http://www.ncbi.nlm.nih.gov/pubmed/9802569
Reactome	R-HSA-549127	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-549127
RefSeq	NP_001302430	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001302430
RefSeq	NP_001302431	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001302431
RefSeq	NP_002546	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002546
RefSeq	NP_899056	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_899056
STRING	9606.ENSP00000307859	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000307859&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.2.53	http://www.tcdb.org/search/result.php?tc=2.A.1.2.53
UCSC	uc001lwx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001lwx&org=rat
UniGene	Hs.50868	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.50868
UniProtKB	S22AI_HUMAN	http://www.uniprot.org/uniprot/S22AI_HUMAN
UniProtKB-AC	Q96BI1	http://www.uniprot.org/uniprot/Q96BI1
charge	swissprot:S22AI_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S22AI_HUMAN
eggNOG	ENOG410IIP5	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IIP5
eggNOG	ENOG4111F2C	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111F2C
epestfind	swissprot:S22AI_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S22AI_HUMAN
garnier	swissprot:S22AI_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S22AI_HUMAN
helixturnhelix	swissprot:S22AI_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S22AI_HUMAN
hmoment	swissprot:S22AI_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S22AI_HUMAN
iep	swissprot:S22AI_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S22AI_HUMAN
inforesidue	swissprot:S22AI_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S22AI_HUMAN
neXtProt	NX_Q96BI1	http://www.nextprot.org/db/entry/NX_Q96BI1
octanol	swissprot:S22AI_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S22AI_HUMAN
pepcoil	swissprot:S22AI_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S22AI_HUMAN
pepdigest	swissprot:S22AI_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S22AI_HUMAN
pepinfo	swissprot:S22AI_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S22AI_HUMAN
pepnet	swissprot:S22AI_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S22AI_HUMAN
pepstats	swissprot:S22AI_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S22AI_HUMAN
pepwheel	swissprot:S22AI_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S22AI_HUMAN
pepwindow	swissprot:S22AI_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S22AI_HUMAN
sigcleave	swissprot:S22AI_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S22AI_HUMAN
## Database	ID	URL or Descriptions
# AltName	CAD17_HUMAN	Intestinal peptide-associated transporter HPT-1
# AltName	CAD17_HUMAN	Liver-intestine cadherin
# ChiTaRS	CDH17	human
# DOMAIN	CAD17_HUMAN	Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. {ECO 0000250}. 
# Ensembl	ENST00000027335	ENSP00000027335; ENSG00000079112
# Ensembl	ENST00000450165	ENSP00000401468; ENSG00000079112
# ExpressionAtlas	Q12864	baseline and differential
# FUNCTION	CAD17_HUMAN	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport. {ECO 0000269|PubMed 8153632}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0009986	cell surface; IEA:Ensembl.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0016323	basolateral plasma membrane; IDA:UniProtKB.
# GO_function	GO:0005178	integrin binding; IPI:UniProtKB.
# GO_function	GO:0005215	transporter activity; TAS:ProtInc.
# GO_function	GO:0005427	proton-dependent oligopeptide secondary active transmembrane transporter activity; ISS:UniProtKB.
# GO_function	GO:0005509	calcium ion binding; IEA:InterPro.
# GO_process	GO:0002314	germinal center B cell differentiation; IEA:Ensembl.
# GO_process	GO:0002315	marginal zone B cell differentiation; IEA:Ensembl.
# GO_process	GO:0006810	transport; NAS:ProtInc.
# GO_process	GO:0006857	oligopeptide transport; ISS:UniProtKB.
# GO_process	GO:0007155	cell adhesion; TAS:ProtInc.
# GO_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules; ISS:UniProtKB.
# GO_process	GO:0007229	integrin-mediated signaling pathway; IMP:UniProtKB.
# GO_process	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; ISS:UniProtKB.
# GO_process	GO:0033626	positive regulation of integrin activation by cell surface receptor linked signal transduction; IMP:UniProtKB.
# GO_process	GO:0034332	adherens junction organization; TAS:Reactome.
# GO_process	GO:0035672	oligopeptide transmembrane transport; ISS:UniProtKB.
# GO_process	GO:0048536	spleen development; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007155	cell adhesion
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0034330	cell junction organization
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.40.60	-; 6.
# Genevisible	Q12864	HS
# HGNC	HGNC:1756	CDH17
# InterPro	IPR002126	Cadherin
# InterPro	IPR015919	Cadherin-like
# InterPro	IPR020894	Cadherin_CS
# KEGG_Brite	ko04516	Cell adhesion molecules and their ligands
# MIM	603017	gene
# Organism	CAD17_HUMAN	Homo sapiens (Human)
# PIR	S55396	S55396
# PRINTS	PR00205	CADHERIN
# PROSITE	PS00232	CADHERIN_1; 3
# PROSITE	PS50268	CADHERIN_2; 6
# Pfam	PF00028	Cadherin; 5
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-418990	Adherens junctions interactions
# RecName	CAD17_HUMAN	Cadherin-17
# RefSeq	NP_001138135	NM_001144663.1
# RefSeq	NP_004054	NM_004063.3
# SIMILARITY	Contains 7 cadherin domains. {ECO:0000255|PROSITE- ProRule	PRU00043}. 
# SMART	SM00112	CA; 6
# SUBCELLULAR LOCATION	CAD17_HUMAN	Cell membrane {ECO 0000305}; Single-pass type I membrane protein {ECO 0000305}. 
# SUPFAM	SSF49313	SSF49313; 7
# TISSUE SPECIFICITY	Expressed in the gastrointestinal tract and pancreatic duct. Not detected in kidney, lung, liver, brain, adrenal gland and skin. {ECO:0000269|PubMed	8153632}. 
# UCSC	uc003ygh	human
# WEB RESOURCE	CAD17_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/CDH17ID40020ch8q22.html";
# eggNOG	ENOG410XQHI	LUCA
# eggNOG	KOG3594	Eukaryota
BLAST	swissprot:CAD17_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CAD17_HUMAN
BioCyc	ZFISH:ENSG00000079112-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000079112-MONOMER
COXPRESdb	1015	http://coxpresdb.jp/data/gene/1015.shtml
CleanEx	HS_CDH17	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CDH17
DOI	10.1038/nature04406	http://dx.doi.org/10.1038/nature04406
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.8153632	http://dx.doi.org/10.1126/science.8153632
EMBL	AP003351	http://www.ebi.ac.uk/ena/data/view/AP003351
EMBL	AP003478	http://www.ebi.ac.uk/ena/data/view/AP003478
EMBL	BC112013	http://www.ebi.ac.uk/ena/data/view/BC112013
EMBL	BC113464	http://www.ebi.ac.uk/ena/data/view/BC113464
EMBL	U07969	http://www.ebi.ac.uk/ena/data/view/U07969
EMBL	X83228	http://www.ebi.ac.uk/ena/data/view/X83228
Ensembl	ENST00000027335	http://www.ensembl.org/id/ENST00000027335
Ensembl	ENST00000450165	http://www.ensembl.org/id/ENST00000450165
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_function	GO:0005178	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005178
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0005427	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005427
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_process	GO:0002314	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002314
GO_process	GO:0002315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002315
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006857
GO_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GO_process	GO:0007156	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007156
GO_process	GO:0007229	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007229
GO_process	GO:0016339	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016339
GO_process	GO:0033626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033626
GO_process	GO:0034332	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034332
GO_process	GO:0035672	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035672
GO_process	GO:0048536	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048536
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0034330	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034330
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.40.60	http://www.cathdb.info/version/latest/superfamily/2.60.40.60
GeneCards	CDH17	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CDH17
GeneID	1015	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1015
GeneTree	ENSGT00740000115559	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00740000115559
H-InvDB	HIX0025563	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0025563
HGNC	HGNC:1756	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1756
HOGENOM	HOG000231613	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231613&db=HOGENOM6
HOVERGEN	HBG050767	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050767&db=HOVERGEN
HPA	CAB025143	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB025143
HPA	HPA023614	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA023614
HPA	HPA023616	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA023616
HPA	HPA026556	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA026556
InParanoid	Q12864	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q12864
IntAct	Q12864	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q12864*
InterPro	IPR002126	http://www.ebi.ac.uk/interpro/entry/IPR002126
InterPro	IPR015919	http://www.ebi.ac.uk/interpro/entry/IPR015919
InterPro	IPR020894	http://www.ebi.ac.uk/interpro/entry/IPR020894
Jabion	1015	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1015
KEGG_Brite	ko04516	http://www.genome.jp/dbget-bin/www_bget?ko04516
KEGG_Gene	hsa:1015	http://www.genome.jp/dbget-bin/www_bget?hsa:1015
KEGG_Orthology	KO:K06811	http://www.genome.jp/dbget-bin/www_bget?KO:K06811
MIM	603017	http://www.ncbi.nlm.nih.gov/omim/603017
MINT	MINT-5000411	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5000411
OMA	GKPFMYV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GKPFMYV
OrthoDB	EOG091G033T	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G033T
PRINTS	PR00205	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00205
PROSITE	PS00232	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00232
PROSITE	PS50268	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50268
PSORT	swissprot:CAD17_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CAD17_HUMAN
PSORT-B	swissprot:CAD17_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CAD17_HUMAN
PSORT2	swissprot:CAD17_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CAD17_HUMAN
Pfam	PF00028	http://pfam.xfam.org/family/PF00028
PharmGKB	PA26290	http://www.pharmgkb.org/do/serve?objId=PA26290&objCls=Gene
Phobius	swissprot:CAD17_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CAD17_HUMAN
PhylomeDB	Q12864	http://phylomedb.org/?seqid=Q12864
ProteinModelPortal	Q12864	http://www.proteinmodelportal.org/query/uniprot/Q12864
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16421571	http://www.ncbi.nlm.nih.gov/pubmed/16421571
PubMed	8153632	http://www.ncbi.nlm.nih.gov/pubmed/8153632
Reactome	R-HSA-418990	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418990
RefSeq	NP_001138135	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001138135
RefSeq	NP_004054	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004054
SMART	SM00112	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00112
STRING	9606.ENSP00000027335	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000027335&targetmode=cogs
SUPFAM	SSF49313	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49313
UCSC	uc003ygh	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ygh&org=rat
UniGene	Hs.591853	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.591853
UniProtKB	CAD17_HUMAN	http://www.uniprot.org/uniprot/CAD17_HUMAN
UniProtKB-AC	Q12864	http://www.uniprot.org/uniprot/Q12864
charge	swissprot:CAD17_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CAD17_HUMAN
eggNOG	ENOG410XQHI	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQHI
eggNOG	KOG3594	http://eggnogapi.embl.de/nog_data/html/tree/KOG3594
epestfind	swissprot:CAD17_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CAD17_HUMAN
garnier	swissprot:CAD17_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CAD17_HUMAN
helixturnhelix	swissprot:CAD17_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CAD17_HUMAN
hmoment	swissprot:CAD17_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CAD17_HUMAN
iep	swissprot:CAD17_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CAD17_HUMAN
inforesidue	swissprot:CAD17_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CAD17_HUMAN
neXtProt	NX_Q12864	http://www.nextprot.org/db/entry/NX_Q12864
octanol	swissprot:CAD17_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CAD17_HUMAN
pepcoil	swissprot:CAD17_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CAD17_HUMAN
pepdigest	swissprot:CAD17_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CAD17_HUMAN
pepinfo	swissprot:CAD17_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CAD17_HUMAN
pepnet	swissprot:CAD17_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CAD17_HUMAN
pepstats	swissprot:CAD17_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CAD17_HUMAN
pepwheel	swissprot:CAD17_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CAD17_HUMAN
pepwindow	swissprot:CAD17_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CAD17_HUMAN
sigcleave	swissprot:CAD17_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CAD17_HUMAN
## Database	ID	URL or Descriptions
# AltName	MOT9_HUMAN	Solute carrier family 16 member 9
# BioGrid	128664	4
# CDD	cd06174	MFS
# ChiTaRS	SLC16A9	human
# Ensembl	ENST00000395347	ENSP00000378756; ENSG00000165449
# Ensembl	ENST00000395348	ENSP00000378757; ENSG00000165449
# FUNCTION	MOT9_HUMAN	Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane. {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016021	integral component of membrane; IBA:GO_Central.
# GO_function	GO:0008028	monocarboxylic acid transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_process	GO:0046415	urate metabolic process; IMP:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# Genevisible	Q7RTY1	HS
# HGNC	HGNC:23520	SLC16A9
# INTERACTION	MOT9_HUMAN	Q14240 EIF4A2; NbExp=3; IntAct=EBI-10232636, EBI-73473; Q9NSK0 KLC4; NbExp=3; IntAct=EBI-10232636, EBI-949319; Q9Y3B7 MRPL11; NbExp=3; IntAct=EBI-10232636, EBI-5453723; 
# IntAct	Q7RTY1	4
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# InterPro	IPR030767	MCT9
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# Organism	MOT9_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11360:SF158	PTHR11360:SF158; 2
# PIR	T34552	T34552
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 10
# RecName	MOT9_HUMAN	Monocarboxylate transporter 9
# RefSeq	NP_001310910	NM_001323981.1
# RefSeq	NP_919274	NM_194298.2
# RefSeq	XP_016871373	XM_017015884.1
# SEQUENCE CAUTION	Sequence=BAD18743.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	MOT9_HUMAN	Cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.1.13.16	the major facilitator superfamily (mfs)
# UCSC	uc010qig	human
# eggNOG	COG0477	LUCA
# eggNOG	KOG2504	Eukaryota
BLAST	swissprot:MOT9_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MOT9_HUMAN
COXPRESdb	220963	http://coxpresdb.jp/data/gene/220963.shtml
CleanEx	HS_SLC16A9	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC16A9
DOI	10.1007/s00424-003-1067-2	http://dx.doi.org/10.1007/s00424-003-1067-2
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AK125791	http://www.ebi.ac.uk/ena/data/view/AK125791
EMBL	AK172758	http://www.ebi.ac.uk/ena/data/view/AK172758
EMBL	AL122071	http://www.ebi.ac.uk/ena/data/view/AL122071
EMBL	BC126238	http://www.ebi.ac.uk/ena/data/view/BC126238
EMBL	BC130567	http://www.ebi.ac.uk/ena/data/view/BC130567
EMBL	BN000144	http://www.ebi.ac.uk/ena/data/view/BN000144
Ensembl	ENST00000395347	http://www.ensembl.org/id/ENST00000395347
Ensembl	ENST00000395348	http://www.ensembl.org/id/ENST00000395348
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0008028	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008028
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_process	GO:0046415	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046415
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GeneCards	SLC16A9	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC16A9
GeneID	220963	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=220963
GeneTree	ENSGT00760000118926	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118926
HGNC	HGNC:23520	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:23520
HOGENOM	HOG000113632	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000113632&db=HOGENOM6
HOVERGEN	HBG097515	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG097515&db=HOVERGEN
HPA	HPA049286	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA049286
InParanoid	Q7RTY1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q7RTY1
IntAct	Q7RTY1	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q7RTY1*
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
InterPro	IPR030767	http://www.ebi.ac.uk/interpro/entry/IPR030767
Jabion	220963	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=220963
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:220963	http://www.genome.jp/dbget-bin/www_bget?hsa:220963
KEGG_Orthology	KO:K08186	http://www.genome.jp/dbget-bin/www_bget?KO:K08186
OMA	EEEFIMP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EEEFIMP
OrthoDB	EOG091G04XL	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G04XL
PANTHER	PTHR11360:SF158	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11360:SF158
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:MOT9_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MOT9_HUMAN
PSORT-B	swissprot:MOT9_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MOT9_HUMAN
PSORT2	swissprot:MOT9_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MOT9_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA134991247	http://www.pharmgkb.org/do/serve?objId=PA134991247&objCls=Gene
Phobius	swissprot:MOT9_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MOT9_HUMAN
PhylomeDB	Q7RTY1	http://phylomedb.org/?seqid=Q7RTY1
ProteinModelPortal	Q7RTY1	http://www.proteinmodelportal.org/query/uniprot/Q7RTY1
PubMed	12739169	http://www.ncbi.nlm.nih.gov/pubmed/12739169
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
RefSeq	NP_001310910	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001310910
RefSeq	NP_919274	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_919274
RefSeq	XP_016871373	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016871373
STRING	9606.ENSP00000378756	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000378756&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.13.16	http://www.tcdb.org/search/result.php?tc=2.A.1.13.16
UCSC	uc010qig	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010qig&org=rat
UniGene	Hs.499709	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.499709
UniProtKB	MOT9_HUMAN	http://www.uniprot.org/uniprot/MOT9_HUMAN
UniProtKB-AC	Q7RTY1	http://www.uniprot.org/uniprot/Q7RTY1
charge	swissprot:MOT9_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MOT9_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG2504	http://eggnogapi.embl.de/nog_data/html/tree/KOG2504
epestfind	swissprot:MOT9_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MOT9_HUMAN
garnier	swissprot:MOT9_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MOT9_HUMAN
helixturnhelix	swissprot:MOT9_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MOT9_HUMAN
hmoment	swissprot:MOT9_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MOT9_HUMAN
iep	swissprot:MOT9_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MOT9_HUMAN
inforesidue	swissprot:MOT9_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MOT9_HUMAN
neXtProt	NX_Q7RTY1	http://www.nextprot.org/db/entry/NX_Q7RTY1
octanol	swissprot:MOT9_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MOT9_HUMAN
pepcoil	swissprot:MOT9_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MOT9_HUMAN
pepdigest	swissprot:MOT9_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MOT9_HUMAN
pepinfo	swissprot:MOT9_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MOT9_HUMAN
pepnet	swissprot:MOT9_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MOT9_HUMAN
pepstats	swissprot:MOT9_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MOT9_HUMAN
pepwheel	swissprot:MOT9_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MOT9_HUMAN
pepwindow	swissprot:MOT9_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MOT9_HUMAN
sigcleave	swissprot:MOT9_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MOT9_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ZP3_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=ZP3A; IsoId=P21754-1; Sequence=Displayed; Name=ZP3B; IsoId=P21754-2; Sequence=VSP_006949, VSP_006950; Note=Found in a second polymorphic locus which, due to an extra G residue in exon 8, has the potential to encode a truncated protein of 372 amino acids.; Name=3; IsoId=P21754-3; Sequence=VSP_037556; 
# AltName	ZP3_HUMAN	Sperm receptor
# AltName	ZP3_HUMAN	ZP3A/ZP3B
# AltName	ZP3_HUMAN	Zona pellucida glycoprotein 3
# AltName	ZP3_HUMAN	Zona pellucida protein C
# AltName	ZP3_HUMAN	Zona pellucida protein C
# BioGrid	113565	7
# CCDS	CCDS47618	-. [P21754-1]
# CCDS	CCDS5586	-. [P21754-3]
# DOMAIN	ZP3_HUMAN	The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida. 
# Ensembl	ENST00000336517	ENSP00000337310; ENSG00000188372. [P21754-3]
# Ensembl	ENST00000394857	ENSP00000378326; ENSG00000188372. [P21754-1]
# ExpressionAtlas	P21754	baseline and differential
# FUNCTION	ZP3_HUMAN	The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation. 
# GO_component	GO:0002081	outer acrosomal membrane; ISS:UniProtKB.
# GO_component	GO:0005576	extracellular region; TAS:Reactome.
# GO_component	GO:0005578	proteinaceous extracellular matrix; IEA:UniProtKB-SubCell.
# GO_component	GO:0005615	extracellular space; IMP:UniProtKB.
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005771	multivesicular body; ISS:UniProtKB.
# GO_component	GO:0005783	endoplasmic reticulum; ISS:UniProtKB.
# GO_component	GO:0005794	Golgi apparatus; ISS:UniProtKB.
# GO_component	GO:0005886	plasma membrane; ISS:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0030141	secretory granule; ISS:UniProtKB.
# GO_component	GO:0031012	extracellular matrix; IDA:UniProtKB.
# GO_component	GO:0048471	perinuclear region of cytoplasm; ISS:UniProtKB.
# GO_function	GO:0004871	signal transducer activity; IMP:UniProtKB.
# GO_function	GO:0005384	manganese ion transmembrane transporter activity; ISS:UniProtKB.
# GO_function	GO:0015279	store-operated calcium channel activity; IDA:UniProtKB.
# GO_function	GO:0030246	carbohydrate binding; IDA:UniProtKB.
# GO_function	GO:0032190	acrosin binding; IPI:UniProtKB.
# GO_process	GO:0001809	positive regulation of type IV hypersensitivity; ISS:UniProtKB.
# GO_process	GO:0001825	blastocyst formation; ISS:UniProtKB.
# GO_process	GO:0002455	humoral immune response mediated by circulating immunoglobulin; ISS:UniProtKB.
# GO_process	GO:0002687	positive regulation of leukocyte migration; ISS:UniProtKB.
# GO_process	GO:0002922	positive regulation of humoral immune response; IDA:UniProtKB.
# GO_process	GO:0006828	manganese ion transport; ISS:UniProtKB.
# GO_process	GO:0006886	intracellular protein transport; ISS:UniProtKB.
# GO_process	GO:0007339	binding of sperm to zona pellucida; IDA:UniProtKB.
# GO_process	GO:0010513	positive regulation of phosphatidylinositol biosynthetic process; ISS:UniProtKB.
# GO_process	GO:0032729	positive regulation of interferon-gamma production; ISS:UniProtKB.
# GO_process	GO:0032753	positive regulation of interleukin-4 production; ISS:UniProtKB.
# GO_process	GO:0035556	intracellular signal transduction; IMP:UniProtKB.
# GO_process	GO:0035803	egg coat formation; ISS:UniProtKB.
# GO_process	GO:0042102	positive regulation of T cell proliferation; ISS:UniProtKB.
# GO_process	GO:0045860	positive regulation of protein kinase activity; IDA:UniProtKB.
# GO_process	GO:0045892	negative regulation of transcription, DNA-templated; ISS:UniProtKB.
# GO_process	GO:0045893	positive regulation of transcription, DNA-templated; ISS:UniProtKB.
# GO_process	GO:0048015	phosphatidylinositol-mediated signaling; ISS:UniProtKB.
# GO_process	GO:0048599	oocyte development; ISS:UniProtKB.
# GO_process	GO:0050729	positive regulation of inflammatory response; ISS:UniProtKB.
# GO_process	GO:0051897	positive regulation of protein kinase B signaling; ISS:UniProtKB.
# GO_process	GO:0070528	protein kinase C signaling; IMP:UniProtKB.
# GO_process	GO:0090280	positive regulation of calcium ion import; IDA:UniProtKB.
# GO_process	GO:2000344	positive regulation of acrosome reaction; IDA:UniProtKB.
# GO_process	GO:2000360	negative regulation of binding of sperm to zona pellucida; IDA:UniProtKB.
# GO_process	GO:2000368	positive regulation of acrosomal vesicle exocytosis; IDA:UniProtKB.
# GO_process	GO:2000386	positive regulation of ovarian follicle development; ISS:UniProtKB.
# GO_process	GO:2000388	positive regulation of antral ovarian follicle growth; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005576	extracellular region
# GOslim_component	GO:0005578	proteinaceous extracellular matrix
# GOslim_component	GO:0005615	extracellular space
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048646	anatomical structure formation involved in morphogenesis
# GOslim_process	GO:0048856	anatomical structure development
# Genevisible	P21754	HS
# HGNC	HGNC:13189	ZP3
# InterPro	IPR001507	ZP_dom
# InterPro	IPR017977	ZP_dom_CS
# MIM	182889	gene
# Organism	ZP3_HUMAN	Homo sapiens (Human)
# PIR	A36000	A36000
# PRINTS	PR00023	ZPELLUCIDA
# PROSITE	PS00682	ZP_1
# PROSITE	PS51034	ZP_2
# PTM	ZP3_HUMAN	N-glycosylated. {ECO 0000250}. 
# PTM	ZP3_HUMAN	O-glycosylated; removal of O-linked glycans may play an important role in the post-fertilization block to polyspermy. {ECO 0000250}. 
# PTM	ZP3_HUMAN	Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida. {ECO 0000269|PubMed 15379548}. 
# Pfam	PF00100	Zona_pellucida
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-1300644	Interaction With The Zona Pellucida
# RecName	ZP3_HUMAN	Processed zona pellucida sperm-binding protein 3
# RecName	ZP3_HUMAN	Zona pellucida sperm-binding protein 3
# RefSeq	NP_001103824	NM_001110354.1. [P21754-1]
# RefSeq	NP_009086	NM_007155.5. [P21754-3]
# SIMILARITY	Belongs to the ZP domain family. ZPC subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 ZP domain. {ECO:0000255|PROSITE- ProRule	PRU00375}. 
# SMART	SM00241	ZP
# SUBCELLULAR LOCATION	ZP3_HUMAN	Cell membrane {ECO 0000250|UniProtKB P48833}; Single-pass type I membrane protein {ECO 0000255}. 
# SUBCELLULAR LOCATION	ZP3_HUMAN	Processed zona pellucida sperm-binding protein 3  Secreted, extracellular space, extracellular matrix {ECO 0000250|UniProtKB P48833}. Note=The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian oocyte is called zona pellucida. {ECO 0000305}. 
# SUBUNIT	Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers. {ECO	0000250}. 
# TISSUE SPECIFICITY	ZP3_HUMAN	Oocytes. 
# UCSC	uc003ufc	human. [P21754-1]
# WEB RESOURCE	ZP3_HUMAN	Name=Protein Spotlight; Note=Molecular chastity - Issue 93 of April 2008; URL="http //web.expasy.org/spotlight/back_issues/093";
# eggNOG	ENOG410II9V	Eukaryota
# eggNOG	ENOG410YXE1	LUCA
BLAST	swissprot:ZP3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ZP3_HUMAN
BioCyc	ZFISH:ENSG00000177546-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000177546-MONOMER
COXPRESdb	7784	http://coxpresdb.jp/data/gene/7784.shtml
CleanEx	HS_ZP3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ZP3
DOI	10.1016/S0888-7543(05)80130-2	http://dx.doi.org/10.1016/S0888-7543(05)80130-2
DOI	10.1021/bi048958k	http://dx.doi.org/10.1021/bi048958k
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.87.16.6014	http://dx.doi.org/10.1073/pnas.87.16.6014
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC005522	http://www.ebi.ac.uk/ena/data/view/AC005522
EMBL	AK292763	http://www.ebi.ac.uk/ena/data/view/AK292763
EMBL	BC113949	http://www.ebi.ac.uk/ena/data/view/BC113949
EMBL	M60504	http://www.ebi.ac.uk/ena/data/view/M60504
EMBL	X56777	http://www.ebi.ac.uk/ena/data/view/X56777
Ensembl	ENST00000336517	http://www.ensembl.org/id/ENST00000336517
Ensembl	ENST00000394857	http://www.ensembl.org/id/ENST00000394857
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0002081	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002081
GO_component	GO:0005576	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576
GO_component	GO:0005578	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005578
GO_component	GO:0005615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005615
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005771	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005771
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030141	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030141
GO_component	GO:0031012	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031012
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GO_function	GO:0005384	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005384
GO_function	GO:0015279	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015279
GO_function	GO:0030246	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030246
GO_function	GO:0032190	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032190
GO_process	GO:0001809	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001809
GO_process	GO:0001825	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001825
GO_process	GO:0002455	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002455
GO_process	GO:0002687	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002687
GO_process	GO:0002922	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002922
GO_process	GO:0006828	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006828
GO_process	GO:0006886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006886
GO_process	GO:0007339	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007339
GO_process	GO:0010513	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010513
GO_process	GO:0032729	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032729
GO_process	GO:0032753	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032753
GO_process	GO:0035556	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035556
GO_process	GO:0035803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035803
GO_process	GO:0042102	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042102
GO_process	GO:0045860	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045860
GO_process	GO:0045892	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892
GO_process	GO:0045893	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893
GO_process	GO:0048015	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048015
GO_process	GO:0048599	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048599
GO_process	GO:0050729	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050729
GO_process	GO:0051897	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051897
GO_process	GO:0070528	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070528
GO_process	GO:0090280	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090280
GO_process	GO:2000344	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000344
GO_process	GO:2000360	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000360
GO_process	GO:2000368	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000368
GO_process	GO:2000386	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000386
GO_process	GO:2000388	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000388
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005576	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576
GOslim_component	GO:0005578	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005578
GOslim_component	GO:0005615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005615
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048646	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048646
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GeneCards	ZP3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ZP3
GeneID	7784	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7784
GeneTree	ENSGT00530000063482	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063482
HGNC	HGNC:13189	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13189
HOGENOM	HOG000220813	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220813&db=HOGENOM6
HOVERGEN	HBG007985	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG007985&db=HOVERGEN
HPA	HPA054061	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA054061
InParanoid	P21754	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21754
InterPro	IPR001507	http://www.ebi.ac.uk/interpro/entry/IPR001507
InterPro	IPR017977	http://www.ebi.ac.uk/interpro/entry/IPR017977
Jabion	7784	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7784
KEGG_Gene	hsa:7784	http://www.genome.jp/dbget-bin/www_bget?hsa:7784
MIM	182889	http://www.ncbi.nlm.nih.gov/omim/182889
OMA	NRRHVTE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NRRHVTE
OrthoDB	EOG091G0AQ6	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0AQ6
PRINTS	PR00023	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00023
PROSITE	PS00682	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00682
PROSITE	PS51034	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51034
PSORT	swissprot:ZP3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ZP3_HUMAN
PSORT-B	swissprot:ZP3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ZP3_HUMAN
PSORT2	swissprot:ZP3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ZP3_HUMAN
Pfam	PF00100	http://pfam.xfam.org/family/PF00100
PharmGKB	PA37757	http://www.pharmgkb.org/do/serve?objId=PA37757&objCls=Gene
Phobius	swissprot:ZP3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ZP3_HUMAN
PhylomeDB	P21754	http://phylomedb.org/?seqid=P21754
ProteinModelPortal	P21754	http://www.proteinmodelportal.org/query/uniprot/P21754
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	1478648	http://www.ncbi.nlm.nih.gov/pubmed/1478648
PubMed	15379548	http://www.ncbi.nlm.nih.gov/pubmed/15379548
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	2385582	http://www.ncbi.nlm.nih.gov/pubmed/2385582
Reactome	R-HSA-1300644	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1300644
RefSeq	NP_001103824	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001103824
RefSeq	NP_009086	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_009086
SMART	SM00241	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00241
SMR	P21754	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21754
STRING	9606.ENSP00000378326	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000378326&targetmode=cogs
UCSC	uc003ufc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ufc&org=rat
UniGene	Hs.656137	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.656137
UniProtKB	ZP3_HUMAN	http://www.uniprot.org/uniprot/ZP3_HUMAN
UniProtKB-AC	P21754	http://www.uniprot.org/uniprot/P21754
charge	swissprot:ZP3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ZP3_HUMAN
eggNOG	ENOG410II9V	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410II9V
eggNOG	ENOG410YXE1	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YXE1
epestfind	swissprot:ZP3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ZP3_HUMAN
garnier	swissprot:ZP3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ZP3_HUMAN
helixturnhelix	swissprot:ZP3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZP3_HUMAN
hmoment	swissprot:ZP3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ZP3_HUMAN
iep	swissprot:ZP3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ZP3_HUMAN
inforesidue	swissprot:ZP3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ZP3_HUMAN
neXtProt	NX_P21754	http://www.nextprot.org/db/entry/NX_P21754
octanol	swissprot:ZP3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ZP3_HUMAN
pepcoil	swissprot:ZP3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ZP3_HUMAN
pepdigest	swissprot:ZP3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ZP3_HUMAN
pepinfo	swissprot:ZP3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ZP3_HUMAN
pepnet	swissprot:ZP3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ZP3_HUMAN
pepstats	swissprot:ZP3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ZP3_HUMAN
pepwheel	swissprot:ZP3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ZP3_HUMAN
pepwindow	swissprot:ZP3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ZP3_HUMAN
sigcleave	swissprot:ZP3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ZP3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SO1B3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NPD5-1; Sequence=Displayed; Name=2; IsoId=Q9NPD5-2; Sequence=VSP_056615, VSP_056616, VSP_056617; 
# AltName	SO1B3_HUMAN	Liver-specific organic anion transporter 2
# AltName	SO1B3_HUMAN	Organic anion transporter 8
# AltName	SO1B3_HUMAN	Organic anion-transporting polypeptide 8
# AltName	SO1B3_HUMAN	Solute carrier family 21 member 8
# CCDS	CCDS8684	-. [Q9NPD5-1]
# CDD	cd06174	MFS
# DISEASE	SO1B3_HUMAN	Hyperbilirubinemia, Rotor type (HBLRR) [MIM 237450]  An autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal. {ECO 0000269|PubMed 22232210}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00175	Pravastatin
# DrugBank	DB00177	Valsartan
# DrugBank	DB00275	Olmesartan
# DrugBank	DB00279	Liothyronine
# DrugBank	DB00286	Conjugated Estrogens
# DrugBank	DB00390	Digoxin
# DrugBank	DB00451	Levothyroxine
# DrugBank	DB00520	Caspofungin
# DrugBank	DB00563	Methotrexate
# DrugBank	DB00688	Mycophenolate mofetil
# DrugBank	DB00783	Estradiol
# DrugBank	DB00950	Fexofenadine
# DrugBank	DB01045	Rifampicin
# DrugBank	DB01076	Atorvastatin
# DrugBank	DB01092	Ouabain
# DrugBank	DB01095	Fluvastatin
# DrugBank	DB01098	Rosuvastatin
# DrugBank	DB01132	Pioglitazone
# DrugBank	DB01211	Clarithromycin
# DrugBank	DB01229	Paclitaxel
# DrugBank	DB01248	Docetaxel
# DrugBank	DB01583	Liotrix
# DrugBank	DB02659	Cholic Acid
# DrugBank	DB05239	Cobimetinib
# DrugBank	DB06176	Romidepsin
# DrugBank	DB06403	Ambrisentan
# DrugBank	DB06772	Cabazitaxel
# DrugBank	DB08860	Pitavastatin
# DrugBank	DB08862	Cholecystokinin
# DrugBank	DB08864	Rilpivirine
# DrugBank	DB08884	Gadoxetate
# DrugBank	DB08912	Dabrafenib
# DrugBank	DB09054	Idelalisib
# DrugBank	DB09102	Daclatasvir
# DrugBank	DB09292	Sacubitril
# DrugBank	DB11362	Selexipag
# Ensembl	ENST00000261196	ENSP00000261196; ENSG00000111700. [Q9NPD5-1]
# Ensembl	ENST00000381545	ENSP00000370956; ENSG00000111700. [Q9NPD5-1]
# ExpressionAtlas	Q9NPD5	baseline and differential
# FUNCTION	SO1B3_HUMAN	Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver. {ECO 0000269|PubMed 22232210}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0008514	organic anion transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0015125	bile acid transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015347	sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0008206	bile acid metabolic process; IBA:GO_Central.
# GO_process	GO:0015711	organic anion transport; TAS:ProtInc.
# GO_process	GO:0015721	bile acid and bile salt transport; TAS:Reactome.
# GO_process	GO:0043252	sodium-independent organic anion transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0044281	small molecule metabolic process
# Genevisible	Q9NPD5	HS
# HGNC	HGNC:10961	SLCO1B3
# InterPro	IPR002350	Kazal_dom
# InterPro	IPR004156	OA_transporter
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04976	Bile secretion
# MIM	237450	phenotype
# MIM	605495	gene
# Organism	SO1B3_HUMAN	Homo sapiens (Human)
# Orphanet	3111	Rotor syndrome
# PANTHER	PTHR11388	PTHR11388
# PROSITE	PS50850	MFS
# PROSITE	PS51465	KAZAL_2
# PTM	SO1B3_HUMAN	N-glycosylated. {ECO 0000269|PubMed 10779507}. 
# Pfam	PF03137	OATP
# Pfam	PF07648	Kazal_2
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-159418	Recycling of bile acids and salts
# Reactome	R-HSA-879518	Transport of organic anions
# RecName	SO1B3_HUMAN	Solute carrier organic anion transporter family member 1B3
# RefSeq	NP_062818	NM_019844.3. [Q9NPD5-1]
# SIMILARITY	Belongs to the organo anion transporter (TC 2.A.60) family. {ECO	0000305}. 
# SIMILARITY	Contains 1 Kazal-like domain. {ECO:0000255|PROSITE- ProRule	PRU00798}.
# SUBCELLULAR LOCATION	SO1B3_HUMAN	Basolateral cell membrane; Multi-pass membrane protein. 
# SUPFAM	SSF103473	SSF103473; 5
# TCDB	2.A.60.1.12	the organo anion transporter (oat) family
# TIGRFAMs	TIGR00805	oat
# TISSUE SPECIFICITY	SO1B3_HUMAN	Highly expressed in liver, in particular at the basolateral membrane of hepatocytes near the central vein. Not detected in other tissues. Highly expressed in some cancer cell lines derived from colon, pancreas, liver and gall bladder. 
# UCSC	uc001rel	human. [Q9NPD5-1]
# eggNOG	ENOG410XRSF	LUCA
# eggNOG	KOG3626	Eukaryota
BLAST	swissprot:SO1B3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SO1B3_HUMAN
BioCyc	ZFISH:ENSG00000111700-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000111700-MONOMER
COXPRESdb	28234	http://coxpresdb.jp/data/gene/28234.shtml
CleanEx	HS_SLCO1B3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLCO1B3
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1053/gast.2001.24804	http://dx.doi.org/10.1053/gast.2001.24804
DOI	10.1074/jbc.M001448200	http://dx.doi.org/10.1074/jbc.M001448200
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1172/JCI59526	http://dx.doi.org/10.1172/JCI59526
DrugBank	DB00175	http://www.drugbank.ca/drugs/DB00175
DrugBank	DB00177	http://www.drugbank.ca/drugs/DB00177
DrugBank	DB00275	http://www.drugbank.ca/drugs/DB00275
DrugBank	DB00279	http://www.drugbank.ca/drugs/DB00279
DrugBank	DB00286	http://www.drugbank.ca/drugs/DB00286
DrugBank	DB00390	http://www.drugbank.ca/drugs/DB00390
DrugBank	DB00451	http://www.drugbank.ca/drugs/DB00451
DrugBank	DB00520	http://www.drugbank.ca/drugs/DB00520
DrugBank	DB00563	http://www.drugbank.ca/drugs/DB00563
DrugBank	DB00688	http://www.drugbank.ca/drugs/DB00688
DrugBank	DB00783	http://www.drugbank.ca/drugs/DB00783
DrugBank	DB00950	http://www.drugbank.ca/drugs/DB00950
DrugBank	DB01045	http://www.drugbank.ca/drugs/DB01045
DrugBank	DB01076	http://www.drugbank.ca/drugs/DB01076
DrugBank	DB01092	http://www.drugbank.ca/drugs/DB01092
DrugBank	DB01095	http://www.drugbank.ca/drugs/DB01095
DrugBank	DB01098	http://www.drugbank.ca/drugs/DB01098
DrugBank	DB01132	http://www.drugbank.ca/drugs/DB01132
DrugBank	DB01211	http://www.drugbank.ca/drugs/DB01211
DrugBank	DB01229	http://www.drugbank.ca/drugs/DB01229
DrugBank	DB01248	http://www.drugbank.ca/drugs/DB01248
DrugBank	DB01583	http://www.drugbank.ca/drugs/DB01583
DrugBank	DB02659	http://www.drugbank.ca/drugs/DB02659
DrugBank	DB05239	http://www.drugbank.ca/drugs/DB05239
DrugBank	DB06176	http://www.drugbank.ca/drugs/DB06176
DrugBank	DB06403	http://www.drugbank.ca/drugs/DB06403
DrugBank	DB06772	http://www.drugbank.ca/drugs/DB06772
DrugBank	DB08860	http://www.drugbank.ca/drugs/DB08860
DrugBank	DB08862	http://www.drugbank.ca/drugs/DB08862
DrugBank	DB08864	http://www.drugbank.ca/drugs/DB08864
DrugBank	DB08884	http://www.drugbank.ca/drugs/DB08884
DrugBank	DB08912	http://www.drugbank.ca/drugs/DB08912
DrugBank	DB09054	http://www.drugbank.ca/drugs/DB09054
DrugBank	DB09102	http://www.drugbank.ca/drugs/DB09102
DrugBank	DB09292	http://www.drugbank.ca/drugs/DB09292
DrugBank	DB11362	http://www.drugbank.ca/drugs/DB11362
EMBL	AC011604	http://www.ebi.ac.uk/ena/data/view/AC011604
EMBL	AC087309	http://www.ebi.ac.uk/ena/data/view/AC087309
EMBL	AF187815	http://www.ebi.ac.uk/ena/data/view/AF187815
EMBL	AJ251506	http://www.ebi.ac.uk/ena/data/view/AJ251506
EMBL	AJ400763	http://www.ebi.ac.uk/ena/data/view/AJ400763
EMBL	AJ400764	http://www.ebi.ac.uk/ena/data/view/AJ400764
EMBL	AJ400765	http://www.ebi.ac.uk/ena/data/view/AJ400765
EMBL	AJ400766	http://www.ebi.ac.uk/ena/data/view/AJ400766
EMBL	AJ400767	http://www.ebi.ac.uk/ena/data/view/AJ400767
EMBL	AJ400768	http://www.ebi.ac.uk/ena/data/view/AJ400768
EMBL	AJ400769	http://www.ebi.ac.uk/ena/data/view/AJ400769
EMBL	AJ400770	http://www.ebi.ac.uk/ena/data/view/AJ400770
EMBL	AJ400771	http://www.ebi.ac.uk/ena/data/view/AJ400771
EMBL	AJ400772	http://www.ebi.ac.uk/ena/data/view/AJ400772
EMBL	AJ400773	http://www.ebi.ac.uk/ena/data/view/AJ400773
EMBL	AJ400774	http://www.ebi.ac.uk/ena/data/view/AJ400774
EMBL	AJ400775	http://www.ebi.ac.uk/ena/data/view/AJ400775
EMBL	AJ400776	http://www.ebi.ac.uk/ena/data/view/AJ400776
EMBL	AY257471	http://www.ebi.ac.uk/ena/data/view/AY257471
EMBL	AY442326	http://www.ebi.ac.uk/ena/data/view/AY442326
Ensembl	ENST00000261196	http://www.ensembl.org/id/ENST00000261196
Ensembl	ENST00000381545	http://www.ensembl.org/id/ENST00000381545
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_function	GO:0008514	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008514
GO_function	GO:0015125	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015125
GO_function	GO:0015347	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015347
GO_process	GO:0008206	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008206
GO_process	GO:0015711	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015711
GO_process	GO:0015721	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015721
GO_process	GO:0043252	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043252
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GeneCards	SLCO1B3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLCO1B3
GeneID	28234	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=28234
GeneTree	ENSGT00760000119014	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119014
HGNC	HGNC:10961	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10961
HOGENOM	HOG000231269	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231269&db=HOGENOM6
HOVERGEN	HBG063896	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG063896&db=HOVERGEN
HPA	HPA004943	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA004943
HPA	HPA050892	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA050892
InParanoid	Q9NPD5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NPD5
InterPro	IPR002350	http://www.ebi.ac.uk/interpro/entry/IPR002350
InterPro	IPR004156	http://www.ebi.ac.uk/interpro/entry/IPR004156
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	28234	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=28234
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:28234	http://www.genome.jp/dbget-bin/www_bget?hsa:28234
KEGG_Orthology	KO:K05043	http://www.genome.jp/dbget-bin/www_bget?KO:K05043
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
MIM	237450	http://www.ncbi.nlm.nih.gov/omim/237450
MIM	605495	http://www.ncbi.nlm.nih.gov/omim/605495
OMA	FLNNGEH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FLNNGEH
Orphanet	3111	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=3111
OrthoDB	EOG091G08QD	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08QD
PANTHER	PTHR11388	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11388
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PROSITE	PS51465	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51465
PSORT	swissprot:SO1B3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SO1B3_HUMAN
PSORT-B	swissprot:SO1B3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SO1B3_HUMAN
PSORT2	swissprot:SO1B3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SO1B3_HUMAN
Pfam	PF03137	http://pfam.xfam.org/family/PF03137
Pfam	PF07648	http://pfam.xfam.org/family/PF07648
PharmGKB	PA35844	http://www.pharmgkb.org/do/serve?objId=PA35844&objCls=Gene
Phobius	swissprot:SO1B3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SO1B3_HUMAN
PhylomeDB	Q9NPD5	http://phylomedb.org/?seqid=Q9NPD5
ProteinModelPortal	Q9NPD5	http://www.proteinmodelportal.org/query/uniprot/Q9NPD5
PubMed	10779507	http://www.ncbi.nlm.nih.gov/pubmed/10779507
PubMed	11375950	http://www.ncbi.nlm.nih.gov/pubmed/11375950
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	22232210	http://www.ncbi.nlm.nih.gov/pubmed/22232210
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
Reactome	R-HSA-159418	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-159418
Reactome	R-HSA-879518	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-879518
RefSeq	NP_062818	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_062818
STRING	9606.ENSP00000261196	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000261196&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.60.1.12	http://www.tcdb.org/search/result.php?tc=2.A.60.1.12
TIGRFAMs	TIGR00805	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00805
UCSC	uc001rel	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001rel&org=rat
UniGene	Hs.504966	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.504966
UniProtKB	SO1B3_HUMAN	http://www.uniprot.org/uniprot/SO1B3_HUMAN
UniProtKB-AC	Q9NPD5	http://www.uniprot.org/uniprot/Q9NPD5
charge	swissprot:SO1B3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SO1B3_HUMAN
eggNOG	ENOG410XRSF	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRSF
eggNOG	KOG3626	http://eggnogapi.embl.de/nog_data/html/tree/KOG3626
epestfind	swissprot:SO1B3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SO1B3_HUMAN
garnier	swissprot:SO1B3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SO1B3_HUMAN
helixturnhelix	swissprot:SO1B3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SO1B3_HUMAN
hmoment	swissprot:SO1B3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SO1B3_HUMAN
iep	swissprot:SO1B3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SO1B3_HUMAN
inforesidue	swissprot:SO1B3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SO1B3_HUMAN
neXtProt	NX_Q9NPD5	http://www.nextprot.org/db/entry/NX_Q9NPD5
octanol	swissprot:SO1B3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SO1B3_HUMAN
pepcoil	swissprot:SO1B3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SO1B3_HUMAN
pepdigest	swissprot:SO1B3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SO1B3_HUMAN
pepinfo	swissprot:SO1B3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SO1B3_HUMAN
pepnet	swissprot:SO1B3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SO1B3_HUMAN
pepstats	swissprot:SO1B3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SO1B3_HUMAN
pepwheel	swissprot:SO1B3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SO1B3_HUMAN
pepwindow	swissprot:SO1B3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SO1B3_HUMAN
sigcleave	swissprot:SO1B3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SO1B3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S28A3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9HAS3-1; Sequence=Displayed; Name=2; Synonyms=hCNT3ins; IsoId=Q9HAS3-2; Sequence=VSP_053848; Note=Exhibits a shorter half-life than isoform 1, degraded via a proteasome-dependent pathway.; 
# AltName	S28A3_HUMAN	Concentrative Na(+)-nucleoside cotransporter 3
# BIOPHYSICOCHEMICAL PROPERTIES	S28A3_HUMAN	Kinetic parameters  KM=21.6 uM for uridine {ECO 0000269|PubMed 11032837, ECO 0000269|PubMed 15861042}; KM=15.4 uM for cytidine {ECO 0000269|PubMed 11032837, ECO 0000269|PubMed 15861042}; KM=21.2 uM for thymidine {ECO 0000269|PubMed 11032837, ECO 0000269|PubMed 15861042}; KM=15.1 uM for adenosine {ECO 0000269|PubMed 11032837, ECO 0000269|PubMed 15861042}; KM=43 uM for guanosine {ECO 0000269|PubMed 11032837, ECO 0000269|PubMed 15861042}; KM=52.5 uM for inosine {ECO 0000269|PubMed 11032837, ECO 0000269|PubMed 15861042}; Vmax=25.8 pmol/min/mg enzyme for uridine uptake {ECO 0000269|PubMed 11032837, ECO 0000269|PubMed 15861042}; Vmax=32.8 pmol/min/mg enzyme for cytidine uptake {ECO 0000269|PubMed 11032837, ECO 0000269|PubMed 15861042}; Vmax=24.2 pmol/min/mg enzyme for thymidine uptake {ECO 0000269|PubMed 11032837, ECO 0000269|PubMed 15861042}; Vmax=30.4 pmol/min/mg enzyme for adenosine uptake {ECO 0000269|PubMed 11032837, ECO 0000269|PubMed 15861042}; Vmax=51.4 pmol/min/mg enzyme for guanosine uptake {ECO 0000269|PubMed 11032837, ECO 0000269|PubMed 15861042}; Vmax=44.8 pmol/min/mg enzyme for inosine uptake {ECO 0000269|PubMed 11032837, ECO 0000269|PubMed 15861042}; 
# CCDS	CCDS6670	-. [Q9HAS3-1]
# ChiTaRS	SLC28A3	human
# DrugBank	DB00242	Cladribine
# DrugBank	DB00441	Gemcitabine
# DrugBank	DB00640	Adenosine
# DrugBank	DB00811	Ribavirin
# DrugBank	DB01033	Mercaptopurine
# DrugBank	DB01073	Fludarabine
# Ensembl	ENST00000376238	ENSP00000365413; ENSG00000197506. [Q9HAS3-1]
# FUNCTION	S28A3_HUMAN	Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2 1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine. {ECO 0000269|PubMed 11032837, ECO 0000269|PubMed 16446384, ECO 0000269|PubMed 17140564}. 
# GO_component	GO:0005789	endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	S28A3_HUMAN	GO 0005415 nucleoside sodium symporter activity; TAS Reactome.
# GO_function	S28A3_HUMAN	GO 0015389 pyrimidine- and adenine-specific sodium symporter activity; IBA GO_Central.
# GO_function	S28A3_HUMAN	GO 0015390 purine-specific nucleoside sodium symporter activity; IBA GO_Central.
# GO_process	GO:0015864	pyrimidine nucleoside transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q9HAS3	HS
# HGNC	HGNC:16484	SLC28A3
# INDUCTION	Up-regulated by phorbol myristate acetate (PMA) in HL- 60 cells. {ECO:0000269|PubMed	11032837}. 
# InterPro	IPR002668	CNT_N_dom
# InterPro	IPR008276	C_nuclsd_transpt
# InterPro	IPR011642	Gate_dom
# InterPro	IPR011657	CNT_C_dom
# InterPro	IPR018270	C_nuclsd_transpt_met_bac
# InterPro	IPR030211	CNT3
# KEGG_Brite	ko02001	Solute carrier family
# MIM	608269	gene
# Organism	S28A3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10590	PTHR10590
# PANTHER	PTHR10590:SF18	PTHR10590:SF18
# Pfam	PF01773	Nucleos_tra2_N
# Pfam	PF07662	Nucleos_tra2_C
# Pfam	PF07670	Gate
# Proteomes	UP000005640	Chromosome 9
# Reactome	R-HSA-83936	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
# RecName	S28A3_HUMAN	Solute carrier family 28 member 3
# RefSeq	NP_001186562	NM_001199633.1. [Q9HAS3-1]
# RefSeq	NP_071410	NM_022127.2. [Q9HAS3-1]
# SIMILARITY	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S28A3_HUMAN	Isoform 1  Cell membrane; Multi-pass membrane protein. 
# SUBCELLULAR LOCATION	S28A3_HUMAN	Isoform 2  Endoplasmic reticulum membrane; Multi-pass membrane protein. 
# TCDB	2.A.41.2	the concentrative nucleoside transporter (cnt) family
# TIGRFAMs	TIGR00804	nupC
# TISSUE SPECIFICITY	Expressed in pancreas, bone marrow, trachea, mammary gland, liver, prostate, and regions of intestine, brain, lung, placenta, testis, kidney, and heart. {ECO:0000269|PubMed	11032837}. 
# UCSC	uc010mpz	human. [Q9HAS3-1]
# eggNOG	COG1972	LUCA
# eggNOG	KOG3747	Eukaryota
BLAST	swissprot:S28A3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S28A3_HUMAN
BioCyc	ZFISH:G66-31706-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31706-MONOMER
COXPRESdb	64078	http://coxpresdb.jp/data/gene/64078.shtml
CleanEx	HS_SLC28A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC28A3
DOI	10.1016/j.ejphar.2006.10.062	http://dx.doi.org/10.1016/j.ejphar.2006.10.062
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.tpj.6500303	http://dx.doi.org/10.1038/sj.tpj.6500303
DOI	10.1074/jbc.M007746200	http://dx.doi.org/10.1074/jbc.M007746200
DOI	10.1096/fj.08-113902	http://dx.doi.org/10.1096/fj.08-113902
DOI	10.1097/01213011-200503000-00006	http://dx.doi.org/10.1097/01213011-200503000-00006
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1124/mol.105.018945	http://dx.doi.org/10.1124/mol.105.018945
DOI	10.1124/mol.107.041848	http://dx.doi.org/10.1124/mol.107.041848
DrugBank	DB00242	http://www.drugbank.ca/drugs/DB00242
DrugBank	DB00441	http://www.drugbank.ca/drugs/DB00441
DrugBank	DB00640	http://www.drugbank.ca/drugs/DB00640
DrugBank	DB00811	http://www.drugbank.ca/drugs/DB00811
DrugBank	DB01033	http://www.drugbank.ca/drugs/DB01033
DrugBank	DB01073	http://www.drugbank.ca/drugs/DB01073
EMBL	AF305210	http://www.ebi.ac.uk/ena/data/view/AF305210
EMBL	AK292849	http://www.ebi.ac.uk/ena/data/view/AK292849
EMBL	AK304406	http://www.ebi.ac.uk/ena/data/view/AK304406
EMBL	AK314039	http://www.ebi.ac.uk/ena/data/view/AK314039
EMBL	AL353787	http://www.ebi.ac.uk/ena/data/view/AL353787
EMBL	AL353787	http://www.ebi.ac.uk/ena/data/view/AL353787
EMBL	AL356134	http://www.ebi.ac.uk/ena/data/view/AL356134
EMBL	AL356134	http://www.ebi.ac.uk/ena/data/view/AL356134
EMBL	BC093821	http://www.ebi.ac.uk/ena/data/view/BC093821
EMBL	BC093823	http://www.ebi.ac.uk/ena/data/view/BC093823
EMBL	CH471089	http://www.ebi.ac.uk/ena/data/view/CH471089
Ensembl	ENST00000376238	http://www.ensembl.org/id/ENST00000376238
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005415	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005415
GO_function	GO:0015389	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015389
GO_function	GO:0015390	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015390
GO_process	GO:0015864	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015864
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC28A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC28A3
GeneID	64078	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64078
GeneTree	ENSGT00390000016025	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000016025
HGNC	HGNC:16484	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16484
HOGENOM	HOG000267658	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267658&db=HOGENOM6
HOVERGEN	HBG054073	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054073&db=HOVERGEN
HPA	HPA023311	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA023311
HPA	HPA024729	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA024729
InParanoid	Q9HAS3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9HAS3
InterPro	IPR002668	http://www.ebi.ac.uk/interpro/entry/IPR002668
InterPro	IPR008276	http://www.ebi.ac.uk/interpro/entry/IPR008276
InterPro	IPR011642	http://www.ebi.ac.uk/interpro/entry/IPR011642
InterPro	IPR011657	http://www.ebi.ac.uk/interpro/entry/IPR011657
InterPro	IPR018270	http://www.ebi.ac.uk/interpro/entry/IPR018270
InterPro	IPR030211	http://www.ebi.ac.uk/interpro/entry/IPR030211
Jabion	64078	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=64078
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:64078	http://www.genome.jp/dbget-bin/www_bget?hsa:64078
KEGG_Orthology	KO:K11536	http://www.genome.jp/dbget-bin/www_bget?KO:K11536
MIM	608269	http://www.ncbi.nlm.nih.gov/omim/608269
OMA	GCCTLLN	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GCCTLLN
OrthoDB	EOG091G05D5	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05D5
PANTHER	PTHR10590	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10590
PANTHER	PTHR10590:SF18	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10590:SF18
PSORT	swissprot:S28A3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S28A3_HUMAN
PSORT-B	swissprot:S28A3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S28A3_HUMAN
PSORT2	swissprot:S28A3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S28A3_HUMAN
Pfam	PF01773	http://pfam.xfam.org/family/PF01773
Pfam	PF07662	http://pfam.xfam.org/family/PF07662
Pfam	PF07670	http://pfam.xfam.org/family/PF07670
PharmGKB	PA426	http://www.pharmgkb.org/do/serve?objId=PA426&objCls=Gene
Phobius	swissprot:S28A3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S28A3_HUMAN
PhylomeDB	Q9HAS3	http://phylomedb.org/?seqid=Q9HAS3
ProteinModelPortal	Q9HAS3	http://www.proteinmodelportal.org/query/uniprot/Q9HAS3
PubMed	11032837	http://www.ncbi.nlm.nih.gov/pubmed/11032837
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15738947	http://www.ncbi.nlm.nih.gov/pubmed/15738947
PubMed	15861042	http://www.ncbi.nlm.nih.gov/pubmed/15861042
PubMed	16446384	http://www.ncbi.nlm.nih.gov/pubmed/16446384
PubMed	17140564	http://www.ncbi.nlm.nih.gov/pubmed/17140564
PubMed	17993510	http://www.ncbi.nlm.nih.gov/pubmed/17993510
PubMed	18827020	http://www.ncbi.nlm.nih.gov/pubmed/18827020
Reactome	R-HSA-83936	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-83936
RefSeq	NP_001186562	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001186562
RefSeq	NP_071410	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_071410
SMR	Q9HAS3	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9HAS3
STRING	9606.ENSP00000365413	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000365413&targetmode=cogs
TCDB	2.A.41.2	http://www.tcdb.org/search/result.php?tc=2.A.41.2
TIGRFAMs	TIGR00804	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00804
UCSC	uc010mpz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010mpz&org=rat
UniGene	Hs.535966	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.535966
UniProtKB	S28A3_HUMAN	http://www.uniprot.org/uniprot/S28A3_HUMAN
UniProtKB-AC	Q9HAS3	http://www.uniprot.org/uniprot/Q9HAS3
charge	swissprot:S28A3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S28A3_HUMAN
eggNOG	COG1972	http://eggnogapi.embl.de/nog_data/html/tree/COG1972
eggNOG	KOG3747	http://eggnogapi.embl.de/nog_data/html/tree/KOG3747
epestfind	swissprot:S28A3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S28A3_HUMAN
garnier	swissprot:S28A3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S28A3_HUMAN
helixturnhelix	swissprot:S28A3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S28A3_HUMAN
hmoment	swissprot:S28A3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S28A3_HUMAN
iep	swissprot:S28A3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S28A3_HUMAN
inforesidue	swissprot:S28A3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S28A3_HUMAN
neXtProt	NX_Q9HAS3	http://www.nextprot.org/db/entry/NX_Q9HAS3
octanol	swissprot:S28A3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S28A3_HUMAN
pepcoil	swissprot:S28A3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S28A3_HUMAN
pepdigest	swissprot:S28A3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S28A3_HUMAN
pepinfo	swissprot:S28A3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S28A3_HUMAN
pepnet	swissprot:S28A3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S28A3_HUMAN
pepstats	swissprot:S28A3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S28A3_HUMAN
pepwheel	swissprot:S28A3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S28A3_HUMAN
pepwindow	swissprot:S28A3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S28A3_HUMAN
sigcleave	swissprot:S28A3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S28A3_HUMAN
## Database	ID	URL or Descriptions
# AltName	Creatine transporter 2 {ECO:0000303|PubMed	23578822}
# AltName	MOT12_HUMAN	Solute carrier family 16 member 12
# CDD	cd06174	MFS
# DISEASE	MOT12_HUMAN	Cataract 47 (CTRCT47) [MIM 612018]  A form of cataract, an opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. CTRCT47 is characterized by the association of cataract with microcornea and renal glucosuria. Microcornea is defined by a corneal diameter inferior to 10 mm in both meridians in an otherwise normal eye. Renal glucosuria is defined by elevated glucose level in the urine without hyperglycemia and without evidence of morphological renal anomalies. {ECO 0000269|PubMed 18304496}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000341233	ENSP00000343022; ENSG00000152779
# FUNCTION	MOT12_HUMAN	Proton-linked monocarboxylate transporter that mediates creatine transport across the plasma membrane. {ECO 0000269|PubMed 23578822}. 
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_function	GO:0005308	creatine transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015129	lactate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_process	GO:0035879	plasma membrane lactate transport; IBA:GO_Central.
# GO_process	GO:1902598	creatine transmembrane transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# HGNC	HGNC:23094	SLC16A12
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H01202	[Eye disease] Cataract
# MIM	611910	gene
# MIM	612018	phenotype
# Organism	MOT12_HUMAN	Homo sapiens (Human)
# Orphanet	247794	Juvenile cataract - microcornea - renal glucosuria
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Unplaced
# RecName	MOT12_HUMAN	Monocarboxylate transporter 12
# RefSeq	NP_998771	NM_213606.3
# SEQUENCE CAUTION	Sequence=BAC85987.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	MOT12_HUMAN	Cell membrane {ECO 0000269|PubMed 23578822}; Multi-pass membrane protein {ECO 0000255, ECO 0000305}. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.1.13.14	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	MOT12_HUMAN	Most highly expressed in kidney, followed by retina, lung, heart and testis. Very weakly expressed in brain and liver. Also detected in lens. {ECO 0000269|PubMed 18304496, ECO 0000269|PubMed 23578822}. 
# eggNOG	COG0477	LUCA
# eggNOG	KOG2504	Eukaryota
BLAST	swissprot:MOT12_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MOT12_HUMAN
BioCyc	ZFISH:ENSG00000152779-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000152779-MONOMER
COXPRESdb	387700	http://coxpresdb.jp/data/gene/387700.shtml
CleanEx	HS_SLC16A12	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC16A12
DOI	10.1016/j.ajhg.2007.12.013	http://dx.doi.org/10.1016/j.ajhg.2007.12.013
DOI	10.1038/nature02462	http://dx.doi.org/10.1038/nature02462
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/hmg/ddt175	http://dx.doi.org/10.1093/hmg/ddt175
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AK124901	http://www.ebi.ac.uk/ena/data/view/AK124901
EMBL	AK127303	http://www.ebi.ac.uk/ena/data/view/AK127303
EMBL	AL353146	http://www.ebi.ac.uk/ena/data/view/AL353146
EMBL	BC086873	http://www.ebi.ac.uk/ena/data/view/BC086873
Ensembl	ENST00000341233	http://www.ensembl.org/id/ENST00000341233
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005308	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005308
GO_function	GO:0015129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015129
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_process	GO:0035879	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035879
GO_process	GO:1902598	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902598
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC16A12	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC16A12
GeneID	387700	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=387700
HGNC	HGNC:23094	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:23094
HOGENOM	HOG000280688	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280688&db=HOGENOM6
HOVERGEN	HBG097674	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG097674&db=HOVERGEN
HPA	HPA037587	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA037587
InParanoid	Q6ZSM3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6ZSM3
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	387700	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=387700
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H01202	http://www.genome.jp/dbget-bin/www_bget?H01202
KEGG_Gene	hsa:387700	http://www.genome.jp/dbget-bin/www_bget?hsa:387700
KEGG_Orthology	KO:K11810	http://www.genome.jp/dbget-bin/www_bget?KO:K11810
MIM	611910	http://www.ncbi.nlm.nih.gov/omim/611910
MIM	612018	http://www.ncbi.nlm.nih.gov/omim/612018
Orphanet	247794	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=247794
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:MOT12_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MOT12_HUMAN
PSORT-B	swissprot:MOT12_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MOT12_HUMAN
PSORT2	swissprot:MOT12_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MOT12_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA134969386	http://www.pharmgkb.org/do/serve?objId=PA134969386&objCls=Gene
Phobius	swissprot:MOT12_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MOT12_HUMAN
PhylomeDB	Q6ZSM3	http://phylomedb.org/?seqid=Q6ZSM3
ProteinModelPortal	Q6ZSM3	http://www.proteinmodelportal.org/query/uniprot/Q6ZSM3
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15164054	http://www.ncbi.nlm.nih.gov/pubmed/15164054
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18304496	http://www.ncbi.nlm.nih.gov/pubmed/18304496
PubMed	23578822	http://www.ncbi.nlm.nih.gov/pubmed/23578822
RefSeq	NP_998771	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_998771
STRING	9606.ENSP00000360855	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000360855&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.13.14	http://www.tcdb.org/search/result.php?tc=2.A.1.13.14
UniGene	Hs.530338	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.530338
UniProtKB	MOT12_HUMAN	http://www.uniprot.org/uniprot/MOT12_HUMAN
UniProtKB-AC	Q6ZSM3	http://www.uniprot.org/uniprot/Q6ZSM3
charge	swissprot:MOT12_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MOT12_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG2504	http://eggnogapi.embl.de/nog_data/html/tree/KOG2504
epestfind	swissprot:MOT12_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MOT12_HUMAN
garnier	swissprot:MOT12_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MOT12_HUMAN
helixturnhelix	swissprot:MOT12_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MOT12_HUMAN
hmoment	swissprot:MOT12_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MOT12_HUMAN
iep	swissprot:MOT12_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MOT12_HUMAN
inforesidue	swissprot:MOT12_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MOT12_HUMAN
neXtProt	NX_Q6ZSM3	http://www.nextprot.org/db/entry/NX_Q6ZSM3
octanol	swissprot:MOT12_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MOT12_HUMAN
pepcoil	swissprot:MOT12_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MOT12_HUMAN
pepdigest	swissprot:MOT12_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MOT12_HUMAN
pepinfo	swissprot:MOT12_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MOT12_HUMAN
pepnet	swissprot:MOT12_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MOT12_HUMAN
pepstats	swissprot:MOT12_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MOT12_HUMAN
pepwheel	swissprot:MOT12_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MOT12_HUMAN
pepwindow	swissprot:MOT12_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MOT12_HUMAN
sigcleave	swissprot:MOT12_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MOT12_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S13A3_HUMAN	Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q8WWT9-1; Sequence=Displayed; Name=2; IsoId=Q8WWT9-2; Sequence=VSP_006123, VSP_006124; Note=Gene prediction based on EST data.; Name=3; IsoId=Q8WWT9-3; Sequence=VSP_015291, VSP_015293; Note=No experimental confirmation available.; Name=4; IsoId=Q8WWT9-4; Sequence=VSP_015292, VSP_015294, VSP_015295; Note=No experimental confirmation available. Gene prediction based on EST data.; Name=5; IsoId=Q8WWT9-5; Sequence=VSP_015292; Note=No experimental confirmation available.; Name=6; IsoId=Q8WWT9-6; Sequence=VSP_015291; Note=No experimental confirmation available. Gene prediction based on EST data.; 
# AltName	S13A3_HUMAN	Na(+)/dicarboxylate cotransporter 3
# AltName	S13A3_HUMAN	Sodium-dependent high-affinity dicarboxylate transporter 2
# CCDS	CCDS13400	-. [Q8WWT9-1]
# CCDS	CCDS42886	-. [Q8WWT9-6]
# CCDS	CCDS54469	-. [Q8WWT9-3]
# CCDS	CCDS54470	-. [Q8WWT9-5]
# ChiTaRS	SLC13A3	human
# DrugBank	DB00139	Succinic acid
# Ensembl	ENST00000279027	ENSP00000279027; ENSG00000158296. [Q8WWT9-1]
# Ensembl	ENST00000290317	ENSP00000290317; ENSG00000158296. [Q8WWT9-6]
# Ensembl	ENST00000413164	ENSP00000415852; ENSG00000158296. [Q8WWT9-5]
# Ensembl	ENST00000472148	ENSP00000420177; ENSG00000158296. [Q8WWT9-3]
# Ensembl	ENST00000495082	ENSP00000419621; ENSG00000158296. [Q8WWT9-6]
# ExpressionAtlas	Q8WWT9	baseline and differential
# FUNCTION	S13A3_HUMAN	High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-5 carbon atoms. The stoichiometry is probably 3 Na(+) for 1 divalent succinate. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0015137	citrate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015141	succinate transmembrane transporter activity; IBA:GO_Central.
# GO_function	S13A3_HUMAN	GO 0015362 high-affinity sodium dicarboxylate symporter activity; TAS Reactome.
# GO_function	S13A3_HUMAN	GO 0017153 sodium dicarboxylate symporter activity; IBA GO_Central.
# GO_process	GO:0015746	citrate transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q8WWT9	HS
# HGNC	HGNC:14430	SLC13A3
# InterPro	IPR001898	Na/sul_symport
# KEGG_Brite	ko02001	Solute carrier family
# MIM	606411	gene
# Organism	S13A3_HUMAN	Homo sapiens (Human)
# Pfam	PF00939	Na_sulph_symp
# Proteomes	UP000005640	Chromosome 20
# Reactome	R-HSA-433137	Sodium-coupled sulphate, di- and tri-carboxylate transporters
# RecName	S13A3_HUMAN	Solute carrier family 13 member 3
# RefSeq	NP_001011554	NM_001011554.2. [Q8WWT9-6]
# RefSeq	NP_001180268	NM_001193339.1. [Q8WWT9-5]
# RefSeq	NP_001180269	NM_001193340.1. [Q8WWT9-3]
# RefSeq	NP_073740	NM_022829.5. [Q8WWT9-1]
# SEQUENCE CAUTION	Sequence=AAF73251.1; Type=Frameshift; Positions=188, 199; Evidence={ECO:0000305}; Sequence=CAC09447.2; Type=Miscellaneous discrepancy; Note=erroneous CDS prediction.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S13A3_HUMAN	Cell membrane {ECO 0000269|PubMed 17426067}; Multi-pass membrane protein {ECO 0000269|PubMed 17426067}. 
# TCDB	2.A.47.1.15:the divalent anion	na(+) symporter (dass) family
# TISSUE SPECIFICITY	S13A3_HUMAN	Expression is highest in kidney. Detected in placenta, brain, liver and pancreas. 
# UCSC	uc002xsf	human. [Q8WWT9-1]
# eggNOG	COG0471	LUCA
# eggNOG	KOG1281	Eukaryota
BLAST	swissprot:S13A3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S13A3_HUMAN
BioCyc	ZFISH:ENSG00000158296-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000158296-MONOMER
COG	COG0471	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0471
COXPRESdb	64849	http://coxpresdb.jp/data/gene/64849.shtml
DOI	10.1038/414865a	http://dx.doi.org/10.1038/414865a
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1096/fj.06-7652com	http://dx.doi.org/10.1096/fj.06-7652com
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DrugBank	DB00139	http://www.drugbank.ca/drugs/DB00139
EMBL	AF154121	http://www.ebi.ac.uk/ena/data/view/AF154121
EMBL	AK056713	http://www.ebi.ac.uk/ena/data/view/AK056713
EMBL	AK096658	http://www.ebi.ac.uk/ena/data/view/AK096658
EMBL	AK295748	http://www.ebi.ac.uk/ena/data/view/AK295748
EMBL	AL034424	http://www.ebi.ac.uk/ena/data/view/AL034424
EMBL	AL133520	http://www.ebi.ac.uk/ena/data/view/AL133520
EMBL	AL442082	http://www.ebi.ac.uk/ena/data/view/AL442082
EMBL	AY072810	http://www.ebi.ac.uk/ena/data/view/AY072810
EMBL	BC035966	http://www.ebi.ac.uk/ena/data/view/BC035966
EMBL	CH471077	http://www.ebi.ac.uk/ena/data/view/CH471077
EMBL	CH471077	http://www.ebi.ac.uk/ena/data/view/CH471077
Ensembl	ENST00000279027	http://www.ensembl.org/id/ENST00000279027
Ensembl	ENST00000290317	http://www.ensembl.org/id/ENST00000290317
Ensembl	ENST00000413164	http://www.ensembl.org/id/ENST00000413164
Ensembl	ENST00000472148	http://www.ensembl.org/id/ENST00000472148
Ensembl	ENST00000495082	http://www.ensembl.org/id/ENST00000495082
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0015137	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015137
GO_function	GO:0015141	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015141
GO_function	GO:0015362	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015362
GO_function	GO:0017153	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017153
GO_process	GO:0015746	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015746
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC13A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC13A3
GeneID	64849	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64849
GeneTree	ENSGT00550000074480	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074480
HGNC	HGNC:14430	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14430
HOGENOM	HOG000278432	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278432&db=HOGENOM6
HOVERGEN	HBG055339	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG055339&db=HOVERGEN
HPA	HPA014353	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014353
HPA	HPA014736	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014736
InParanoid	Q8WWT9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8WWT9
InterPro	IPR001898	http://www.ebi.ac.uk/interpro/entry/IPR001898
Jabion	64849	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=64849
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:64849	http://www.genome.jp/dbget-bin/www_bget?hsa:64849
KEGG_Orthology	KO:K14445	http://www.genome.jp/dbget-bin/www_bget?KO:K14445
MIM	606411	http://www.ncbi.nlm.nih.gov/omim/606411
OMA	VKPAWLI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VKPAWLI
OrthoDB	EOG091G092X	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G092X
PSORT	swissprot:S13A3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S13A3_HUMAN
PSORT-B	swissprot:S13A3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S13A3_HUMAN
PSORT2	swissprot:S13A3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S13A3_HUMAN
Pfam	PF00939	http://pfam.xfam.org/family/PF00939
PharmGKB	PA37881	http://www.pharmgkb.org/do/serve?objId=PA37881&objCls=Gene
Phobius	swissprot:S13A3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S13A3_HUMAN
PhylomeDB	Q8WWT9	http://phylomedb.org/?seqid=Q8WWT9
ProteinModelPortal	Q8WWT9	http://www.proteinmodelportal.org/query/uniprot/Q8WWT9
PubMed	10794676	http://www.ncbi.nlm.nih.gov/pubmed/10794676
PubMed	11780052	http://www.ncbi.nlm.nih.gov/pubmed/11780052
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17426067	http://www.ncbi.nlm.nih.gov/pubmed/17426067
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
Reactome	R-HSA-433137	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-433137
RefSeq	NP_001011554	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001011554
RefSeq	NP_001180268	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001180268
RefSeq	NP_001180269	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001180269
RefSeq	NP_073740	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_073740
STRING	9606.ENSP00000279027	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000279027&targetmode=cogs
STRING	COG0471	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0471&targetmode=cogs
TCDB	2.A.47.1.15	http://www.tcdb.org/search/result.php?tc=2.A.47.1.15
UCSC	uc002xsf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002xsf&org=rat
UniGene	Hs.655498	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.655498
UniGene	Hs.670365	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.670365
UniProtKB	S13A3_HUMAN	http://www.uniprot.org/uniprot/S13A3_HUMAN
UniProtKB-AC	Q8WWT9	http://www.uniprot.org/uniprot/Q8WWT9
charge	swissprot:S13A3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S13A3_HUMAN
eggNOG	COG0471	http://eggnogapi.embl.de/nog_data/html/tree/COG0471
eggNOG	KOG1281	http://eggnogapi.embl.de/nog_data/html/tree/KOG1281
epestfind	swissprot:S13A3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S13A3_HUMAN
garnier	swissprot:S13A3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S13A3_HUMAN
helixturnhelix	swissprot:S13A3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S13A3_HUMAN
hmoment	swissprot:S13A3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S13A3_HUMAN
iep	swissprot:S13A3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S13A3_HUMAN
inforesidue	swissprot:S13A3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S13A3_HUMAN
neXtProt	NX_Q8WWT9	http://www.nextprot.org/db/entry/NX_Q8WWT9
octanol	swissprot:S13A3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S13A3_HUMAN
pepcoil	swissprot:S13A3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S13A3_HUMAN
pepdigest	swissprot:S13A3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S13A3_HUMAN
pepinfo	swissprot:S13A3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S13A3_HUMAN
pepnet	swissprot:S13A3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S13A3_HUMAN
pepstats	swissprot:S13A3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S13A3_HUMAN
pepwheel	swissprot:S13A3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S13A3_HUMAN
pepwindow	swissprot:S13A3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S13A3_HUMAN
sigcleave	swissprot:S13A3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S13A3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9BRV3-1; Sequence=Displayed; Name=2; IsoId=Q9BRV3-2; Sequence=VSP_034916, VSP_034917; Note=Ref.1 (AAF17233) sequence differs from that shown due to frameshifts in positions 29 and 30. {ECO	0000305}; Name=3; IsoId=Q9BRV3-3; Sequence=VSP_034918; 
# AltName	SWET1_HUMAN	RAG1-activating protein 1
# AltName	SWET1_HUMAN	Solute carrier family 50 member 1
# AltName	SWET1_HUMAN	Stromal cell protein
# BioGrid	121020	2
# CCDS	CCDS1093	-. [Q9BRV3-1]
# CCDS	CCDS44238	-. [Q9BRV3-3]
# CCDS	CCDS44239	-. [Q9BRV3-2]
# ChiTaRS	SLC50A1	human
# Ensembl	ENST00000303343	ENSP00000306146; ENSG00000169241. [Q9BRV3-3]
# Ensembl	ENST00000368401	ENSP00000357386; ENSG00000169241. [Q9BRV3-2]
# Ensembl	ENST00000368404	ENSP00000357389; ENSG00000169241. [Q9BRV3-1]
# ExpressionAtlas	Q9BRV3	baseline and differential
# FUNCTION	SWET1_HUMAN	Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1. {ECO 0000269|PubMed 21107422}. 
# GO_component	GO:0000139	Golgi membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005634	nucleus; IC:HGNC.
# GO_component	GO:0005794	Golgi apparatus; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0012505	endomembrane system; ISS:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IBA:GO_Central.
# GO_function	GO:0042947	glucoside transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0051119	sugar transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0008643	carbohydrate transport; IBA:GO_Central.
# GO_process	GO:0045815	positive regulation of gene expression, epigenetic; ISS:HGNC.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q9BRV3	HS
# HGNC	HGNC:30657	SLC50A1
# IntAct	Q9BRV3	2
# InterPro	IPR004316	SWEET_sugar_transpr
# KEGG_Brite	ko02001	Solute carrier family
# MIM	613683	gene
# Organism	SWET1_HUMAN	Homo sapiens (Human)
# Pfam	PF03083	MtN3_slv; 2
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-70153	Glucose transport
# RecName	SWET1_HUMAN	Sugar transporter SWEET1
# RefSeq	NP_001116309	NM_001122837.1. [Q9BRV3-2]
# RefSeq	NP_001116311	NM_001122839.1. [Q9BRV3-3]
# RefSeq	NP_001274515	NM_001287586.1
# RefSeq	NP_001274516	NM_001287587.1
# RefSeq	NP_001274517	NM_001287588.1
# RefSeq	NP_001274519	NM_001287590.1
# RefSeq	NP_001274520	NM_001287591.1
# RefSeq	NP_001274521	NM_001287592.1
# RefSeq	NP_061333	NM_018845.3. [Q9BRV3-1]
# SIMILARITY	Belongs to the SWEET sugar transporter family. {ECO	0000305}. 
# SIMILARITY	Contains 2 MtN3/slv domains. {ECO	0000305}.
# SUBCELLULAR LOCATION	SWET1_HUMAN	Golgi apparatus membrane {ECO 0000269|PubMed 21107422}; Multi-pass membrane protein {ECO 0000269|PubMed 21107422}. Cell membrane {ECO 0000269|PubMed 21107422}; Multi-pass membrane protein {ECO 0000269|PubMed 21107422}. Note=May also localize to the endoplasmic reticulum. {ECO 0000250}. 
# SUBUNIT	Interacts with TRPV2; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation. {ECO	0000250}. 
# TISSUE SPECIFICITY	Ubiquitously expressed with highest expression in oviduct, epididymis and intestine. {ECO:0000269|PubMed	21107422}. 
# UCSC	uc001fhj	human. [Q9BRV3-1]
# eggNOG	ENOG4111M4R	LUCA
# eggNOG	KOG1623	Eukaryota
BLAST	swissprot:SWET1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SWET1_HUMAN
BioCyc	ZFISH:ENSG00000169241-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000169241-MONOMER
COXPRESdb	55974	http://coxpresdb.jp/data/gene/55974.shtml
CleanEx	HS_RAG1AP1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_RAG1AP1
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/nature09606	http://dx.doi.org/10.1038/nature09606
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.160270997	http://dx.doi.org/10.1073/pnas.160270997
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF126023	http://www.ebi.ac.uk/ena/data/view/AF126023
EMBL	AF126024	http://www.ebi.ac.uk/ena/data/view/AF126024
EMBL	AK289551	http://www.ebi.ac.uk/ena/data/view/AK289551
EMBL	AL691442	http://www.ebi.ac.uk/ena/data/view/AL691442
EMBL	AL691442	http://www.ebi.ac.uk/ena/data/view/AL691442
EMBL	AL691442	http://www.ebi.ac.uk/ena/data/view/AL691442
EMBL	BC005943	http://www.ebi.ac.uk/ena/data/view/BC005943
EMBL	BC009621	http://www.ebi.ac.uk/ena/data/view/BC009621
EMBL	CR457148	http://www.ebi.ac.uk/ena/data/view/CR457148
Ensembl	ENST00000303343	http://www.ensembl.org/id/ENST00000303343
Ensembl	ENST00000368401	http://www.ensembl.org/id/ENST00000368401
Ensembl	ENST00000368404	http://www.ensembl.org/id/ENST00000368404
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0012505	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0012505
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0042947	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042947
GO_function	GO:0051119	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051119
GO_process	GO:0008643	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008643
GO_process	GO:0045815	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045815
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	SLC50A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC50A1
GeneID	55974	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55974
GeneTree	ENSGT00390000007801	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000007801
H-InvDB	HIX0199799	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0199799
HGNC	HGNC:30657	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:30657
HOVERGEN	HBG055287	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG055287&db=HOVERGEN
HPA	HPA018095	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA018095
InParanoid	Q9BRV3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9BRV3
IntAct	Q9BRV3	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9BRV3*
InterPro	IPR004316	http://www.ebi.ac.uk/interpro/entry/IPR004316
Jabion	55974	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55974
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:55974	http://www.genome.jp/dbget-bin/www_bget?hsa:55974
KEGG_Orthology	KO:K15382	http://www.genome.jp/dbget-bin/www_bget?KO:K15382
MIM	613683	http://www.ncbi.nlm.nih.gov/omim/613683
OMA	INNLSWL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=INNLSWL
OrthoDB	EOG091G0J82	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0J82
PSORT	swissprot:SWET1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SWET1_HUMAN
PSORT-B	swissprot:SWET1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SWET1_HUMAN
PSORT2	swissprot:SWET1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SWET1_HUMAN
Pfam	PF03083	http://pfam.xfam.org/family/PF03083
PharmGKB	PA142671099	http://www.pharmgkb.org/do/serve?objId=PA142671099&objCls=Gene
Phobius	swissprot:SWET1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SWET1_HUMAN
PhylomeDB	Q9BRV3	http://phylomedb.org/?seqid=Q9BRV3
ProteinModelPortal	Q9BRV3	http://www.proteinmodelportal.org/query/uniprot/Q9BRV3
PubMed	10931946	http://www.ncbi.nlm.nih.gov/pubmed/10931946
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	21107422	http://www.ncbi.nlm.nih.gov/pubmed/21107422
Reactome	R-HSA-70153	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-70153
RefSeq	NP_001116309	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001116309
RefSeq	NP_001116311	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001116311
RefSeq	NP_001274515	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001274515
RefSeq	NP_001274516	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001274516
RefSeq	NP_001274517	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001274517
RefSeq	NP_001274519	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001274519
RefSeq	NP_001274520	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001274520
RefSeq	NP_001274521	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001274521
RefSeq	NP_061333	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061333
STRING	9606.ENSP00000357389	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000357389&targetmode=cogs
UCSC	uc001fhj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001fhj&org=rat
UniGene	Hs.292154	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.292154
UniProtKB	SWET1_HUMAN	http://www.uniprot.org/uniprot/SWET1_HUMAN
UniProtKB-AC	Q9BRV3	http://www.uniprot.org/uniprot/Q9BRV3
charge	swissprot:SWET1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SWET1_HUMAN
eggNOG	ENOG4111M4R	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111M4R
eggNOG	KOG1623	http://eggnogapi.embl.de/nog_data/html/tree/KOG1623
epestfind	swissprot:SWET1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SWET1_HUMAN
garnier	swissprot:SWET1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SWET1_HUMAN
helixturnhelix	swissprot:SWET1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SWET1_HUMAN
hmoment	swissprot:SWET1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SWET1_HUMAN
iep	swissprot:SWET1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SWET1_HUMAN
inforesidue	swissprot:SWET1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SWET1_HUMAN
neXtProt	NX_Q9BRV3	http://www.nextprot.org/db/entry/NX_Q9BRV3
octanol	swissprot:SWET1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SWET1_HUMAN
pepcoil	swissprot:SWET1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SWET1_HUMAN
pepdigest	swissprot:SWET1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SWET1_HUMAN
pepinfo	swissprot:SWET1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SWET1_HUMAN
pepnet	swissprot:SWET1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SWET1_HUMAN
pepstats	swissprot:SWET1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SWET1_HUMAN
pepwheel	swissprot:SWET1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SWET1_HUMAN
pepwindow	swissprot:SWET1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SWET1_HUMAN
sigcleave	swissprot:SWET1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SWET1_HUMAN
## Database	ID	URL or Descriptions
# AltName	S13A1_HUMAN	Renal sodium/sulfate cotransporter
# DrugBank	DB00139	Succinic acid
# Ensembl	ENST00000194130	ENSP00000194130; ENSG00000081800
# ExpressionAtlas	Q9BZW2	baseline and differential
# FUNCTION	S13A1_HUMAN	Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	S13A1_HUMAN	GO 0015382 sodium sulfate symporter activity; IBA GO_Central.
# GO_process	GO:0008272	sulfate transport; IBA:GO_Central.
# GO_process	GO:0035725	sodium ion transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9BZW2	HS
# HGNC	HGNC:10916	SLC13A1
# INDUCTION	S13A1_HUMAN	Inhibited by thiosulfate, selenate, molybdate, tungstate, citrate and succinate. 
# InterPro	IPR001898	Na/sul_symport
# InterPro	IPR031312	Na/sul_symport_CS
# KEGG_Brite	ko02001	Solute carrier family
# MIM	606193	gene
# Organism	S13A1_HUMAN	Homo sapiens (Human)
# PROSITE	PS01271	NA_SULFATE
# Pfam	PF00939	Na_sulph_symp
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-433137	Sodium-coupled sulphate, di- and tri-carboxylate transporters
# RecName	S13A1_HUMAN	Solute carrier family 13 member 1
# RefSeq	NP_001311329	NM_001324400.1
# RefSeq	NP_071889	NM_022444.3
# SIMILARITY	Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	S13A1_HUMAN	Membrane; Multi-pass membrane protein. 
# TCDB	2.A.47.1.16:the divalent anion	na(+) symporter (dass) family
# TISSUE SPECIFICITY	S13A1_HUMAN	Highly expressed in kidney; not detectable in the other tissues tested. 
# UCSC	uc003vkm	human
# eggNOG	COG0471	LUCA
# eggNOG	KOG1281	Eukaryota
BLAST	swissprot:S13A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S13A1_HUMAN
BioCyc	ZFISH:ENSG00000081800-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000081800-MONOMER
COXPRESdb	6561	http://coxpresdb.jp/data/gene/6561.shtml
CleanEx	HS_SLC13A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC13A1
DOI	10.1006/geno.2000.6404	http://dx.doi.org/10.1006/geno.2000.6404
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DrugBank	DB00139	http://www.drugbank.ca/drugs/DB00139
EMBL	AF260824	http://www.ebi.ac.uk/ena/data/view/AF260824
EMBL	AK026413	http://www.ebi.ac.uk/ena/data/view/AK026413
Ensembl	ENST00000194130	http://www.ensembl.org/id/ENST00000194130
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0015382	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015382
GO_process	GO:0008272	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008272
GO_process	GO:0035725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035725
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC13A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC13A1
GeneID	6561	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6561
GeneTree	ENSGT00550000074480	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074480
HGNC	HGNC:10916	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10916
HOGENOM	HOG000278432	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278432&db=HOGENOM6
HOVERGEN	HBG055339	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG055339&db=HOVERGEN
HPA	HPA053615	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA053615
HPA	HPA062714	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA062714
InParanoid	Q9BZW2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9BZW2
InterPro	IPR001898	http://www.ebi.ac.uk/interpro/entry/IPR001898
InterPro	IPR031312	http://www.ebi.ac.uk/interpro/entry/IPR031312
Jabion	6561	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6561
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6561	http://www.genome.jp/dbget-bin/www_bget?hsa:6561
KEGG_Orthology	KO:K14444	http://www.genome.jp/dbget-bin/www_bget?KO:K14444
MIM	606193	http://www.ncbi.nlm.nih.gov/omim/606193
OMA	LPMFGIM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LPMFGIM
OrthoDB	EOG091G092X	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G092X
PROSITE	PS01271	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01271
PSORT	swissprot:S13A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S13A1_HUMAN
PSORT-B	swissprot:S13A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S13A1_HUMAN
PSORT2	swissprot:S13A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S13A1_HUMAN
Pfam	PF00939	http://pfam.xfam.org/family/PF00939
PharmGKB	PA322	http://www.pharmgkb.org/do/serve?objId=PA322&objCls=Gene
Phobius	swissprot:S13A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S13A1_HUMAN
PhylomeDB	Q9BZW2	http://phylomedb.org/?seqid=Q9BZW2
ProteinModelPortal	Q9BZW2	http://www.proteinmodelportal.org/query/uniprot/Q9BZW2
PubMed	11161786	http://www.ncbi.nlm.nih.gov/pubmed/11161786
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
Reactome	R-HSA-433137	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-433137
RefSeq	NP_001311329	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001311329
RefSeq	NP_071889	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_071889
STRING	9606.ENSP00000194130	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000194130&targetmode=cogs
TCDB	2.A.47.1.16	http://www.tcdb.org/search/result.php?tc=2.A.47.1.16
UCSC	uc003vkm	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003vkm&org=rat
UniGene	Hs.489849	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.489849
UniProtKB	S13A1_HUMAN	http://www.uniprot.org/uniprot/S13A1_HUMAN
UniProtKB-AC	Q9BZW2	http://www.uniprot.org/uniprot/Q9BZW2
charge	swissprot:S13A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S13A1_HUMAN
eggNOG	COG0471	http://eggnogapi.embl.de/nog_data/html/tree/COG0471
eggNOG	KOG1281	http://eggnogapi.embl.de/nog_data/html/tree/KOG1281
epestfind	swissprot:S13A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S13A1_HUMAN
garnier	swissprot:S13A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S13A1_HUMAN
helixturnhelix	swissprot:S13A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S13A1_HUMAN
hmoment	swissprot:S13A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S13A1_HUMAN
iep	swissprot:S13A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S13A1_HUMAN
inforesidue	swissprot:S13A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S13A1_HUMAN
neXtProt	NX_Q9BZW2	http://www.nextprot.org/db/entry/NX_Q9BZW2
octanol	swissprot:S13A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S13A1_HUMAN
pepcoil	swissprot:S13A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S13A1_HUMAN
pepdigest	swissprot:S13A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S13A1_HUMAN
pepinfo	swissprot:S13A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S13A1_HUMAN
pepnet	swissprot:S13A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S13A1_HUMAN
pepstats	swissprot:S13A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S13A1_HUMAN
pepwheel	swissprot:S13A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S13A1_HUMAN
pepwindow	swissprot:S13A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S13A1_HUMAN
sigcleave	swissprot:S13A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S13A1_HUMAN
## Database	ID	URL or Descriptions
# AltName	SEC62_HUMAN	Translocation protein 1
# BioGrid	112950	22
# ChiTaRS	SEC62	human
# Ensembl	ENST00000337002	ENSP00000337688; ENSG00000008952
# Ensembl	ENST00000480708	ENSP00000420331; ENSG00000008952
# ExpressionAtlas	Q99442	baseline and differential
# FUNCTION	SEC62_HUMAN	Required for preprotein translocation. {ECO 0000250}. 
# GO_component	GO:0005783	endoplasmic reticulum; IDA:HPA.
# GO_component	GO:0005789	endoplasmic reticulum membrane; TAS:Reactome.
# GO_component	GO:0005791	rough endoplasmic reticulum; ISS:UniProtKB.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0016020	membrane; IDA:MGI.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_component	GO:0016235	aggresome; IDA:HPA.
# GO_component	GO:0045111	intermediate filament cytoskeleton; IDA:HPA.
# GO_function	GO:0004872	receptor activity; TAS:ProtInc.
# GO_function	GO:0008565	protein transporter activity; IEA:InterPro.
# GO_process	GO:0006613	cotranslational protein targeting to membrane; TAS:ProtInc.
# GO_process	GO:0006620	posttranslational protein targeting to membrane; IMP:MGI.
# GO_process	GO:0036498	IRE1-mediated unfolded protein response; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005856	cytoskeleton
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006605	protein targeting
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0061024	membrane organization
# Gene3D	1.10.10.10	-; 2.
# Genevisible	Q99442	HS
# HGNC	HGNC:11846	SEC62
# IntAct	Q99442	15
# InterPro	IPR004728	Sec62
# InterPro	IPR011991	WHTH_DNA-bd_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02044	 Secretion system
# KEGG_Pathway	ko03060	Protein export
# KEGG_Pathway	ko04141	Protein processing in endoplasmic reticulum
# MIM	602173	gene
# Organism	SEC62_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12443	PTHR12443
# PIR	JC5279	JC5279
# Pfam	PF03839	Sec62
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-381038	XBP1(S) activates chaperone genes
# RecName	SEC62_HUMAN	Translocation protein SEC62
# RefSeq	NP_003253	NM_003262.3
# SIMILARITY	Belongs to the SEC62 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	SEC62_HUMAN	Endoplasmic reticulum membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUBUNIT	Part of a complex that contains SEC61, SEC62 and SEC63. Interacts with SEC61B. {ECO:0000269|PubMed	10799540}. 
# TCDB	1.A.15.1	the non-selective cation channel-2 (nscc2) family
# UCSC	uc003fgg	human
# eggNOG	COG5232	LUCA
# eggNOG	KOG2927	Eukaryota
BLAST	swissprot:SEC62_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SEC62_HUMAN
BioCyc	ZFISH:ENSG00000008952-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000008952-MONOMER
COXPRESdb	7095	http://coxpresdb.jp/data/gene/7095.shtml
CleanEx	HS_SEC62	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SEC62
DOI	10.1002/pmic.200700884	http://dx.doi.org/10.1002/pmic.200700884
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/bbrc.1996.5892	http://dx.doi.org/10.1006/bbrc.1996.5892
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1074/jbc.275.19.14550	http://dx.doi.org/10.1074/jbc.275.19.14550
DOI	10.1080/152165499306504	http://dx.doi.org/10.1080/152165499306504
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AB024586	http://www.ebi.ac.uk/ena/data/view/AB024586
EMBL	BC012035	http://www.ebi.ac.uk/ena/data/view/BC012035
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
EMBL	D87127	http://www.ebi.ac.uk/ena/data/view/D87127
EMBL	U93239	http://www.ebi.ac.uk/ena/data/view/U93239
Ensembl	ENST00000337002	http://www.ensembl.org/id/ENST00000337002
Ensembl	ENST00000480708	http://www.ensembl.org/id/ENST00000480708
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005791	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005791
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016235	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016235
GO_component	GO:0045111	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045111
GO_function	GO:0004872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004872
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0006613	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006613
GO_process	GO:0006620	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006620
GO_process	GO:0036498	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036498
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
Gene3D	1.10.10.10	http://www.cathdb.info/version/latest/superfamily/1.10.10.10
GeneCards	SEC62	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SEC62
GeneID	7095	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7095
GeneTree	ENSGT00390000002757	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002757
HGNC	HGNC:11846	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11846
HOGENOM	HOG000016701	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000016701&db=HOGENOM6
HOVERGEN	HBG055550	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG055550&db=HOVERGEN
HPA	HPA014059	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014059
HPA	HPA061450	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA061450
InParanoid	Q99442	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q99442
IntAct	Q99442	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q99442*
InterPro	IPR004728	http://www.ebi.ac.uk/interpro/entry/IPR004728
InterPro	IPR011991	http://www.ebi.ac.uk/interpro/entry/IPR011991
Jabion	7095	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7095
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02044	http://www.genome.jp/dbget-bin/www_bget?ko02044
KEGG_Gene	hsa:7095	http://www.genome.jp/dbget-bin/www_bget?hsa:7095
KEGG_Orthology	KO:K12275	http://www.genome.jp/dbget-bin/www_bget?KO:K12275
KEGG_Pathway	ko03060	http://www.genome.jp/kegg-bin/show_pathway?ko03060
KEGG_Pathway	ko04141	http://www.genome.jp/kegg-bin/show_pathway?ko04141
MIM	602173	http://www.ncbi.nlm.nih.gov/omim/602173
MINT	MINT-2863594	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-2863594
OMA	SNGNDFE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SNGNDFE
OrthoDB	EOG091G0KPB	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0KPB
PANTHER	PTHR12443	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12443
PSORT	swissprot:SEC62_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SEC62_HUMAN
PSORT-B	swissprot:SEC62_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SEC62_HUMAN
PSORT2	swissprot:SEC62_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SEC62_HUMAN
Pfam	PF03839	http://pfam.xfam.org/family/PF03839
PharmGKB	PA162402849	http://www.pharmgkb.org/do/serve?objId=PA162402849&objCls=Gene
Phobius	swissprot:SEC62_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SEC62_HUMAN
PhylomeDB	Q99442	http://phylomedb.org/?seqid=Q99442
ProteinModelPortal	Q99442	http://www.proteinmodelportal.org/query/uniprot/Q99442
PubMed	10683767	http://www.ncbi.nlm.nih.gov/pubmed/10683767
PubMed	10799540	http://www.ncbi.nlm.nih.gov/pubmed/10799540
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	18318008	http://www.ncbi.nlm.nih.gov/pubmed/18318008
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	9020021	http://www.ncbi.nlm.nih.gov/pubmed/9020021
Reactome	R-HSA-381038	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-381038
RefSeq	NP_003253	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003253
STRING	9606.ENSP00000337688	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000337688&targetmode=cogs
TCDB	1.A.15.1	http://www.tcdb.org/search/result.php?tc=1.A.15.1
UCSC	uc003fgg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003fgg&org=rat
UniGene	Hs.744859	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.744859
UniProtKB	SEC62_HUMAN	http://www.uniprot.org/uniprot/SEC62_HUMAN
UniProtKB-AC	Q99442	http://www.uniprot.org/uniprot/Q99442
charge	swissprot:SEC62_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SEC62_HUMAN
eggNOG	COG5232	http://eggnogapi.embl.de/nog_data/html/tree/COG5232
eggNOG	KOG2927	http://eggnogapi.embl.de/nog_data/html/tree/KOG2927
epestfind	swissprot:SEC62_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SEC62_HUMAN
garnier	swissprot:SEC62_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SEC62_HUMAN
helixturnhelix	swissprot:SEC62_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SEC62_HUMAN
hmoment	swissprot:SEC62_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SEC62_HUMAN
iep	swissprot:SEC62_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SEC62_HUMAN
inforesidue	swissprot:SEC62_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SEC62_HUMAN
neXtProt	NX_Q99442	http://www.nextprot.org/db/entry/NX_Q99442
octanol	swissprot:SEC62_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SEC62_HUMAN
pepcoil	swissprot:SEC62_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SEC62_HUMAN
pepdigest	swissprot:SEC62_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SEC62_HUMAN
pepinfo	swissprot:SEC62_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SEC62_HUMAN
pepnet	swissprot:SEC62_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SEC62_HUMAN
pepstats	swissprot:SEC62_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SEC62_HUMAN
pepwheel	swissprot:SEC62_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SEC62_HUMAN
pepwindow	swissprot:SEC62_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SEC62_HUMAN
sigcleave	swissprot:SEC62_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SEC62_HUMAN
## Database	ID	URL or Descriptions
# AltName	IMA4_HUMAN	Importin alpha Q2
# AltName	IMA4_HUMAN	Karyopherin subunit alpha-3
# AltName	IMA4_HUMAN	SRP1-gamma
# BioGrid	110037	78
# CAUTION	Was termed importin alpha-4. {ECO:0000305|PubMed	9395085}.
# ChiTaRS	KPNA3	human
# DOMAIN	IMA4_HUMAN	Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import. 
# DOMAIN	IMA4_HUMAN	The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS- containing proteins (By similarity). {ECO 0000250}. 
# DOMAIN	IMA4_HUMAN	The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity). {ECO 0000250}. 
# Ensembl	ENST00000261667	ENSP00000261667; ENSG00000102753
# ExpressionAtlas	O00505	baseline and differential
# FUNCTION	IMA4_HUMAN	Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9. 
# GO_component	GO:0005643	nuclear pore; TAS:ProtInc.
# GO_component	GO:0005654	nucleoplasm; IBA:GO_Central.
# GO_component	GO:0005829	cytosol; IBA:GO_Central.
# GO_function	GO:0008139	nuclear localization sequence binding; TAS:ProtInc.
# GO_function	GO:0008565	protein transporter activity; IBA:GO_Central.
# GO_process	GO:0006461	protein complex assembly; TAS:ProtInc.
# GO_process	GO:0006607	NLS-bearing protein import into nucleus; TAS:ProtInc.
# GO_process	GO:0019054	modulation by virus of host process; TAS:Reactome.
# GO_process	GO:0046718	viral entry into host cell; IEA:UniProtKB-KW.
# GO_process	GO:0075732	viral penetration into host nucleus; IEA:UniProtKB-KW.
# GO_process	GO:0075733	intracellular transport of virus; TAS:Reactome.
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# Gene3D	1.25.10.10	-; 1.
# Genevisible	O00505	HS
# HGNC	HGNC:6396	KPNA3
# INTERACTION	IMA4_HUMAN	P46527 CDKN1B; NbExp=4; IntAct=EBI-358297, EBI-519280; P19447 ERCC3; NbExp=3; IntAct=EBI-358297, EBI-1183307; Q8K4J6 Mkl1 (xeno); NbExp=9; IntAct=EBI-358297, EBI-8291665; 
# IntAct	O00505	63
# InterPro	IPR000225	Armadillo
# InterPro	IPR002652	Importin-a_IBB
# InterPro	IPR011989	ARM-like
# InterPro	IPR016024	ARM-type_fold
# InterPro	IPR024931	Importing_su_alpha
# InterPro	IPR032413	Arm_3
# MIM	601892	gene
# Organism	IMA4_HUMAN	Homo sapiens (Human)
# PIRSF	PIRSF005673	Importin_alpha
# PROSITE	PS50176	ARM_REPEAT; 3
# PROSITE	PS51214	IBB
# Pfam	PF00514	Arm; 8
# Pfam	PF01749	IBB
# Pfam	PF16186	Arm_3
# Proteomes	UP000005640	Chromosome 13
# Reactome	R-HSA-1169408	ISG15 antiviral mechanism
# Reactome	R-HSA-168276	NS1 Mediated Effects on Host Pathways
# RecName	IMA4_HUMAN	Importin subunit alpha-4
# RefSeq	NP_002258	NM_002267.3
# SIMILARITY	Belongs to the importin alpha family. {ECO	0000305}. 
# SIMILARITY	Contains 1 IBB domain. {ECO:0000255|PROSITE- ProRule	PRU00561}. 
# SIMILARITY	Contains 10 ARM repeats. {ECO:0000255|PROSITE- ProRule	PRU00259}. 
# SMART	SM00185	ARM; 8
# SUBCELLULAR LOCATION	IMA4_HUMAN	Cytoplasm {ECO 0000250}. Nucleus {ECO 0000250}. 
# SUBUNIT	IMA4_HUMAN	Forms a complex with importin subunit beta-1. Interacts with HIV-1 integrase; this interaction might play a role in nuclear import of HIV pre-integration complex. Interacts with influenza virus nucleoprotein; this interaction might play a role in nuclear import of viral genome. Interacts with NCBP2/CBP20 and NCBP3 (PubMed 26382858). {ECO 0000269|PubMed 12740372, ECO 0000269|PubMed 20554775, ECO 0000269|PubMed 26382858}. 
# SUPFAM	SSF48371	SSF48371
# TCDB	1.I.1.1	the nuclear pore complex (npc) family
# TISSUE SPECIFICITY	IMA4_HUMAN	Ubiquitous. Highest levels in heart and skeletal muscle. 
# UCSC	uc001vdj	human
# eggNOG	COG5064	LUCA
# eggNOG	KOG0166	Eukaryota
BLAST	swissprot:IMA4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:IMA4_HUMAN
BioCyc	ZFISH:ENSG00000102753-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000102753-MONOMER
COXPRESdb	3839	http://coxpresdb.jp/data/gene/3839.shtml
CleanEx	HS_KPNA3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KPNA3
DIP	DIP-27586N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-27586N
DOI	10.1002/pmic.200700884	http://dx.doi.org/10.1002/pmic.200700884
DOI	10.1016/S0014-5793(97)01265-9	http://dx.doi.org/10.1016/S0014-5793(97)01265-9
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature02379	http://dx.doi.org/10.1038/nature02379
DOI	10.1038/ncomms9192	http://dx.doi.org/10.1038/ncomms9192
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.95.2.582	http://dx.doi.org/10.1073/pnas.95.2.582
DOI	10.1074/jbc.M303571200	http://dx.doi.org/10.1074/jbc.M303571200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1128/JVI.00508-10	http://dx.doi.org/10.1128/JVI.00508-10
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF005263	http://www.ebi.ac.uk/ena/data/view/AF005263
EMBL	AF034756	http://www.ebi.ac.uk/ena/data/view/AF034756
EMBL	AK290528	http://www.ebi.ac.uk/ena/data/view/AK290528
EMBL	AK291000	http://www.ebi.ac.uk/ena/data/view/AK291000
EMBL	AL135901	http://www.ebi.ac.uk/ena/data/view/AL135901
EMBL	AL135901	http://www.ebi.ac.uk/ena/data/view/AL135901
EMBL	AL136301	http://www.ebi.ac.uk/ena/data/view/AL136301
EMBL	AL136301	http://www.ebi.ac.uk/ena/data/view/AL136301
EMBL	BC017355	http://www.ebi.ac.uk/ena/data/view/BC017355
EMBL	BC024202	http://www.ebi.ac.uk/ena/data/view/BC024202
EMBL	CH471075	http://www.ebi.ac.uk/ena/data/view/CH471075
EMBL	D89618	http://www.ebi.ac.uk/ena/data/view/D89618
EMBL	Y12394	http://www.ebi.ac.uk/ena/data/view/Y12394
Ensembl	ENST00000261667	http://www.ensembl.org/id/ENST00000261667
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005643	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005643
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_function	GO:0008139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008139
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GO_process	GO:0006607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006607
GO_process	GO:0019054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019054
GO_process	GO:0046718	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046718
GO_process	GO:0075732	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0075732
GO_process	GO:0075733	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0075733
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
GeneCards	KPNA3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KPNA3
GeneID	3839	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3839
GeneTree	ENSGT00760000119094	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119094
HGNC	HGNC:6396	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6396
HOGENOM	HOG000167616	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000167616&db=HOGENOM6
HOVERGEN	HBG001846	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG001846&db=HOVERGEN
HPA	HPA046852	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA046852
InParanoid	O00505	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O00505
IntAct	O00505	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O00505*
InterPro	IPR000225	http://www.ebi.ac.uk/interpro/entry/IPR000225
InterPro	IPR002652	http://www.ebi.ac.uk/interpro/entry/IPR002652
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
InterPro	IPR024931	http://www.ebi.ac.uk/interpro/entry/IPR024931
InterPro	IPR032413	http://www.ebi.ac.uk/interpro/entry/IPR032413
Jabion	3839	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3839
KEGG_Gene	hsa:3839	http://www.genome.jp/dbget-bin/www_bget?hsa:3839
MIM	601892	http://www.ncbi.nlm.nih.gov/omim/601892
MINT	MINT-88920	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-88920
OMA	NCDVLSY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NCDVLSY
OrthoDB	EOG091G095Z	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G095Z
PROSITE	PS50176	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50176
PROSITE	PS51214	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51214
PSORT	swissprot:IMA4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:IMA4_HUMAN
PSORT-B	swissprot:IMA4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:IMA4_HUMAN
PSORT2	swissprot:IMA4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:IMA4_HUMAN
Pfam	PF00514	http://pfam.xfam.org/family/PF00514
Pfam	PF01749	http://pfam.xfam.org/family/PF01749
Pfam	PF16186	http://pfam.xfam.org/family/PF16186
PharmGKB	PA30187	http://www.pharmgkb.org/do/serve?objId=PA30187&objCls=Gene
Phobius	swissprot:IMA4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:IMA4_HUMAN
PhylomeDB	O00505	http://phylomedb.org/?seqid=O00505
ProteinModelPortal	O00505	http://www.proteinmodelportal.org/query/uniprot/O00505
PubMed	12740372	http://www.ncbi.nlm.nih.gov/pubmed/12740372
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15057823	http://www.ncbi.nlm.nih.gov/pubmed/15057823
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	18318008	http://www.ncbi.nlm.nih.gov/pubmed/18318008
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	20554775	http://www.ncbi.nlm.nih.gov/pubmed/20554775
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	26382858	http://www.ncbi.nlm.nih.gov/pubmed/26382858
PubMed	9154134	http://www.ncbi.nlm.nih.gov/pubmed/9154134
PubMed	9395085	http://www.ncbi.nlm.nih.gov/pubmed/9395085
PubMed	9435235	http://www.ncbi.nlm.nih.gov/pubmed/9435235
Reactome	R-HSA-1169408	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1169408
Reactome	R-HSA-168276	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-168276
RefSeq	NP_002258	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002258
SMART	SM00185	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00185
SMR	O00505	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O00505
STRING	9606.ENSP00000261667	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000261667&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
TCDB	1.I.1.1	http://www.tcdb.org/search/result.php?tc=1.I.1.1
UCSC	uc001vdj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001vdj&org=rat
UniGene	Hs.527919	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.527919
UniProtKB	IMA4_HUMAN	http://www.uniprot.org/uniprot/IMA4_HUMAN
UniProtKB-AC	O00505	http://www.uniprot.org/uniprot/O00505
charge	swissprot:IMA4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:IMA4_HUMAN
eggNOG	COG5064	http://eggnogapi.embl.de/nog_data/html/tree/COG5064
eggNOG	KOG0166	http://eggnogapi.embl.de/nog_data/html/tree/KOG0166
epestfind	swissprot:IMA4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:IMA4_HUMAN
garnier	swissprot:IMA4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:IMA4_HUMAN
helixturnhelix	swissprot:IMA4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:IMA4_HUMAN
hmoment	swissprot:IMA4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:IMA4_HUMAN
iep	swissprot:IMA4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:IMA4_HUMAN
inforesidue	swissprot:IMA4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:IMA4_HUMAN
neXtProt	NX_O00505	http://www.nextprot.org/db/entry/NX_O00505
octanol	swissprot:IMA4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:IMA4_HUMAN
pepcoil	swissprot:IMA4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:IMA4_HUMAN
pepdigest	swissprot:IMA4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:IMA4_HUMAN
pepinfo	swissprot:IMA4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:IMA4_HUMAN
pepnet	swissprot:IMA4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:IMA4_HUMAN
pepstats	swissprot:IMA4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:IMA4_HUMAN
pepwheel	swissprot:IMA4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:IMA4_HUMAN
pepwindow	swissprot:IMA4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:IMA4_HUMAN
sigcleave	swissprot:IMA4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:IMA4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q9NW15-1; Sequence=Displayed; Name=2; IsoId=Q9NW15-2; Sequence=VSP_026033; Note=No experimental confirmation available.; Name=3; IsoId=Q9NW15-3; Sequence=VSP_038212; Note=No experimental confirmation available.; Name=4; IsoId=Q9NW15-4; Sequence=VSP_038211; Note=No experimental confirmation available.; Name=5; IsoId=Q9NW15-5; Sequence=VSP_045885; Note=No experimental confirmation available. Ref.1 (BAG60264) sequence is in conflict in position: 607	S->P. {ECO:0000305}; 
# AltName	ANO10_HUMAN	Transmembrane protein 16K
# BioGrid	120435	3
# CCDS	CCDS2710	-. [Q9NW15-1]
# CCDS	CCDS56247	-. [Q9NW15-4]
# CCDS	CCDS56248	-. [Q9NW15-3]
# CCDS	CCDS56249	-. [Q9NW15-2]
# CCDS	CCDS56250	-. [Q9NW15-5]
# ChiTaRS	ANO10	human
# DISEASE	ANO10_HUMAN	Spinocerebellar ataxia, autosomal recessive, 10 (SCAR10) [MIM 613728]  Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR10 is characterized by onset in the teenage or young adult years of gait and limb ataxia, dysarthria, and nystagmus associated with marked cerebellar atrophy on brain imaging. {ECO 0000269|PubMed 21092923}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000292246	ENSP00000292246; ENSG00000160746. [Q9NW15-1]
# Ensembl	ENST00000350459	ENSP00000327767; ENSG00000160746. [Q9NW15-2]
# Ensembl	ENST00000396091	ENSP00000379398; ENSG00000160746. [Q9NW15-3]
# Ensembl	ENST00000414522	ENSP00000396990; ENSG00000160746. [Q9NW15-5]
# Ensembl	ENST00000451430	ENSP00000394119; ENSG00000160746. [Q9NW15-4]
# ExpressionAtlas	Q9NW15	baseline and differential
# FUNCTION	ANO10_HUMAN	Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1. {ECO 0000269|PubMed 20056604, ECO 0000269|PubMed 22946059}. 
# GO_component	GO:0005622	intracellular; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005227	calcium activated cation channel activity; IDA:UniProtKB.
# GO_function	GO:0005229	intracellular calcium activated chloride channel activity; IDA:UniProtKB.
# GO_process	GO:0006812	cation transport; IDA:UniProtKB.
# GO_process	GO:0006821	chloride transport; IDA:UniProtKB.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005622	intracellular
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9NW15	HS
# HGNC	HGNC:25519	ANO10
# IntAct	Q9NW15	3
# InterPro	IPR007632	Anoctamin
# InterPro	IPR031291	Anoctamin-10
# KEGG_Disease	H00063	[Neurodegenerative disease] Spinocerebellar ataxia (SCA)
# MIM	613726	gene
# MIM	613728	phenotype
# MISCELLANEOUS	ANO10_HUMAN	The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology. 
# Organism	ANO10_HUMAN	Homo sapiens (Human)
# Orphanet	284289	Adult-onset autosomal recessive cerebellar ataxia
# PANTHER	PTHR12308	PTHR12308
# PANTHER	PTHR12308:SF40	PTHR12308:SF40
# Pfam	PF04547	Anoctamin
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	ANO10_HUMAN	Anoctamin-10
# RefSeq	NP_001191760	NM_001204831.1. [Q9NW15-5]
# RefSeq	NP_001191761	NM_001204832.1. [Q9NW15-3]
# RefSeq	NP_001191762	NM_001204833.1. [Q9NW15-4]
# RefSeq	NP_001191763	NM_001204834.1. [Q9NW15-2]
# RefSeq	NP_060545	NM_018075.3. [Q9NW15-1]
# RefSeq	XP_016862210	XM_017006721.1. [Q9NW15-3]
# RefSeq	XP_016862211	XM_017006722.1. [Q9NW15-3]
# SEQUENCE CAUTION	Sequence=BAA91573.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305}; Sequence=BC038855; Type=Frameshift; Positions=42; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the anoctamin family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	ANO10_HUMAN	Cell membrane {ECO 0000269|PubMed 20056604, ECO 0000269|PubMed 22075693, ECO 0000269|PubMed 22946059}; Multi- pass membrane protein {ECO 0000269|PubMed 20056604, ECO 0000269|PubMed 22075693, ECO 0000269|PubMed 22946059}. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane. 
# TISSUE SPECIFICITY	Highly expressed in the brain. Intermediate levels in the retina and heart and low levels in the placenta, liver, lung, duodenum, kidney, testis and spleen. In brain areas, highest expression in the frontal and occipital cortices and in the cerebellum. Lower expression in the fetal brain than in the adult brain. {ECO:0000269|PubMed	21092923}. 
# UCSC	uc003cmv	human. [Q9NW15-1]
# eggNOG	ENOG410XPYE	LUCA
# eggNOG	KOG2513	Eukaryota
BLAST	swissprot:ANO10_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ANO10_HUMAN
BioCyc	ZFISH:ENSG00000160746-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000160746-MONOMER
COXPRESdb	55129	http://coxpresdb.jp/data/gene/55129.shtml
CleanEx	HS_ANO10	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ANO10
DOI	10.1007/s00424-011-0975-9	http://dx.doi.org/10.1007/s00424-011-0975-9
DOI	10.1016/j.ajhg.2010.10.015	http://dx.doi.org/10.1016/j.ajhg.2010.10.015
DOI	10.1038/aps.2011.48	http://dx.doi.org/10.1038/aps.2011.48
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M109.065367	http://dx.doi.org/10.1074/jbc.M109.065367
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1113/expphysiol.2011.058198	http://dx.doi.org/10.1113/expphysiol.2011.058198
DOI	10.1113/expphysiol.2011.058214	http://dx.doi.org/10.1113/expphysiol.2011.058214
DOI	10.1152/ajpcell.00140.2011	http://dx.doi.org/10.1152/ajpcell.00140.2011
DOI	10.1242/jcs.109553	http://dx.doi.org/10.1242/jcs.109553
EMBL	AC097638	http://www.ebi.ac.uk/ena/data/view/AC097638
EMBL	AC104184	http://www.ebi.ac.uk/ena/data/view/AC104184
EMBL	AC105903	http://www.ebi.ac.uk/ena/data/view/AC105903
EMBL	AC135852	http://www.ebi.ac.uk/ena/data/view/AC135852
EMBL	AK001237	http://www.ebi.ac.uk/ena/data/view/AK001237
EMBL	AK096302	http://www.ebi.ac.uk/ena/data/view/AK096302
EMBL	AK131223	http://www.ebi.ac.uk/ena/data/view/AK131223
EMBL	AK292368	http://www.ebi.ac.uk/ena/data/view/AK292368
EMBL	AK295969	http://www.ebi.ac.uk/ena/data/view/AK295969
EMBL	AK297949	http://www.ebi.ac.uk/ena/data/view/AK297949
EMBL	BC038855	http://www.ebi.ac.uk/ena/data/view/BC038855
EMBL	CH471055	http://www.ebi.ac.uk/ena/data/view/CH471055
EMBL	CH471055	http://www.ebi.ac.uk/ena/data/view/CH471055
Ensembl	ENST00000292246	http://www.ensembl.org/id/ENST00000292246
Ensembl	ENST00000350459	http://www.ensembl.org/id/ENST00000350459
Ensembl	ENST00000396091	http://www.ensembl.org/id/ENST00000396091
Ensembl	ENST00000414522	http://www.ensembl.org/id/ENST00000414522
Ensembl	ENST00000451430	http://www.ensembl.org/id/ENST00000451430
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005227	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005227
GO_function	GO:0005229	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005229
GO_process	GO:0006812	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006812
GO_process	GO:0006821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006821
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ANO10	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ANO10
GeneID	55129	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55129
GeneTree	ENSGT00760000119015	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119015
HGNC	HGNC:25519	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:25519
HOGENOM	HOG000007605	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007605&db=HOGENOM6
HOVERGEN	HBG071385	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG071385&db=HOVERGEN
HPA	HPA051569	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA051569
InParanoid	Q9NW15	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NW15
IntAct	Q9NW15	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NW15*
InterPro	IPR007632	http://www.ebi.ac.uk/interpro/entry/IPR007632
InterPro	IPR031291	http://www.ebi.ac.uk/interpro/entry/IPR031291
Jabion	55129	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55129
KEGG_Disease	H00063	http://www.genome.jp/dbget-bin/www_bget?H00063
KEGG_Gene	hsa:55129	http://www.genome.jp/dbget-bin/www_bget?hsa:55129
MIM	613726	http://www.ncbi.nlm.nih.gov/omim/613726
MIM	613728	http://www.ncbi.nlm.nih.gov/omim/613728
OMA	LENQNLY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LENQNLY
Orphanet	284289	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=284289
OrthoDB	EOG091G06A3	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G06A3
PANTHER	PTHR12308	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12308
PANTHER	PTHR12308:SF40	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12308:SF40
PSORT	swissprot:ANO10_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ANO10_HUMAN
PSORT-B	swissprot:ANO10_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ANO10_HUMAN
PSORT2	swissprot:ANO10_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ANO10_HUMAN
Pfam	PF04547	http://pfam.xfam.org/family/PF04547
PharmGKB	PA164715433	http://www.pharmgkb.org/do/serve?objId=PA164715433&objCls=Gene
Phobius	swissprot:ANO10_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ANO10_HUMAN
PhylomeDB	Q9NW15	http://phylomedb.org/?seqid=Q9NW15
ProteinModelPortal	Q9NW15	http://www.proteinmodelportal.org/query/uniprot/Q9NW15
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	20056604	http://www.ncbi.nlm.nih.gov/pubmed/20056604
PubMed	21092923	http://www.ncbi.nlm.nih.gov/pubmed/21092923
PubMed	21607626	http://www.ncbi.nlm.nih.gov/pubmed/21607626
PubMed	21642943	http://www.ncbi.nlm.nih.gov/pubmed/21642943
PubMed	21984732	http://www.ncbi.nlm.nih.gov/pubmed/21984732
PubMed	22075693	http://www.ncbi.nlm.nih.gov/pubmed/22075693
PubMed	22302790	http://www.ncbi.nlm.nih.gov/pubmed/22302790
PubMed	22946059	http://www.ncbi.nlm.nih.gov/pubmed/22946059
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_001191760	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001191760
RefSeq	NP_001191761	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001191761
RefSeq	NP_001191762	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001191762
RefSeq	NP_001191763	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001191763
RefSeq	NP_060545	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060545
RefSeq	XP_016862210	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016862210
RefSeq	XP_016862211	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016862211
STRING	9606.ENSP00000292246	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000292246&targetmode=cogs
UCSC	uc003cmv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003cmv&org=rat
UniGene	Hs.656657	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.656657
UniProtKB	ANO10_HUMAN	http://www.uniprot.org/uniprot/ANO10_HUMAN
UniProtKB-AC	Q9NW15	http://www.uniprot.org/uniprot/Q9NW15
charge	swissprot:ANO10_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ANO10_HUMAN
eggNOG	ENOG410XPYE	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPYE
eggNOG	KOG2513	http://eggnogapi.embl.de/nog_data/html/tree/KOG2513
epestfind	swissprot:ANO10_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ANO10_HUMAN
garnier	swissprot:ANO10_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ANO10_HUMAN
helixturnhelix	swissprot:ANO10_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ANO10_HUMAN
hmoment	swissprot:ANO10_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ANO10_HUMAN
iep	swissprot:ANO10_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ANO10_HUMAN
inforesidue	swissprot:ANO10_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ANO10_HUMAN
neXtProt	NX_Q9NW15	http://www.nextprot.org/db/entry/NX_Q9NW15
octanol	swissprot:ANO10_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ANO10_HUMAN
pepcoil	swissprot:ANO10_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ANO10_HUMAN
pepdigest	swissprot:ANO10_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ANO10_HUMAN
pepinfo	swissprot:ANO10_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ANO10_HUMAN
pepnet	swissprot:ANO10_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ANO10_HUMAN
pepstats	swissprot:ANO10_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ANO10_HUMAN
pepwheel	swissprot:ANO10_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ANO10_HUMAN
pepwindow	swissprot:ANO10_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ANO10_HUMAN
sigcleave	swissprot:ANO10_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ANO10_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	NCKX1_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O60721-1; Sequence=Displayed; Name=2; IsoId=O60721-2; Sequence=VSP_006160; Note=No experimental confirmation available.; Name=3; IsoId=O60721-3; Sequence=VSP_054491; Note=No experimental confirmation available.; 
# AltName	NCKX1_HUMAN	Na(+)/K(+)/Ca(2+)-exchange protein 1
# AltName	NCKX1_HUMAN	Retinal rod Na-Ca+K exchanger
# AltName	NCKX1_HUMAN	Solute carrier family 24 member 1
# BioGrid	114624	2
# CCDS	CCDS45284	-. [O60721-1]
# CCDS	CCDS73742	-. [O60721-3]
# CCDS	CCDS73743	-. [O60721-2]
# DISEASE	NCKX1_HUMAN	Night blindness, congenital stationary, 1D (CSNB1D) [MIM 613830]  An autosomal recessive form of congenital stationary night blindness, a non-progressive retinal disorder characterized by impaired night vision. CSNB1D is characterized by a Riggs type of electroretinogram (proportionally reduced a- and b-waves). Patients have visual acuity within the normal range and no symptoms of myopia and/or nystagmus. {ECO 0000269|PubMed 20850105}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000261892	ENSP00000261892; ENSG00000074621. [O60721-1]
# Ensembl	ENST00000339868	ENSP00000341837; ENSG00000074621. [O60721-3]
# Ensembl	ENST00000399033	ENSP00000381991; ENSG00000074621. [O60721-3]
# Ensembl	ENST00000546330	ENSP00000439190; ENSG00000074621. [O60721-2]
# ExpressionAtlas	O60721	baseline and differential
# FUNCTION	NCKX1_HUMAN	Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). {ECO 0000269|PubMed 10608890}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0019867	outer membrane; NAS:UniProtKB.
# GO_function	GO:0005262	calcium channel activity; IBA:GO_Central.
# GO_function	GO:0005509	calcium ion binding; IBA:GO_Central.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_function	GO:0030955	potassium ion binding; IBA:GO_Central.
# GO_function	GO:0031402	sodium ion binding; IBA:GO_Central.
# GO_function	NCKX1_HUMAN	GO 0008273 calcium, potassium sodium antiporter activity; NAS UniProtKB.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006816	calcium ion transport; NAS:UniProtKB.
# GO_process	GO:0006874	cellular calcium ion homeostasis; IBA:GO_Central.
# GO_process	GO:0007601	visual perception; NAS:UniProtKB.
# GO_process	GO:0009642	response to light intensity; NAS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0050877	neurological system process
# Genevisible	O60721	HS
# HGNC	HGNC:10975	SLC24A1
# INTERACTION	NCKX1_HUMAN	P16333 NCK1; NbExp=3; IntAct=EBI-1753504, EBI-389883; 
# IntAct	O60721	5
# InterPro	IPR004481	K/Na/Ca-exchanger
# InterPro	IPR004817	SLC24A1
# InterPro	IPR004837	NaCa_Exmemb
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H00787	[Nervous system disease; Eye disease] Oguchi disease/ CSNB Oguchi type (CSNBO)
# KEGG_Pathway	ko04744	Phototransduction
# MIM	603617	gene
# MIM	613830	phenotype
# Organism	NCKX1_HUMAN	Homo sapiens (Human)
# Orphanet	215	Congenital stationary night blindness
# PANTHER	PTHR10846	PTHR10846; 4
# PTM	NCKX1_HUMAN	The uncleaved signal sequence is required for efficient membrane targeting and proper membrane integration. 
# Pfam	PF01699	Na_Ca_ex; 2
# Proteomes	UP000005640	Chromosome 15
# Reactome	R-HSA-2485179	Activation of the phototransduction cascade
# Reactome	R-HSA-425561	Sodium/Calcium exchangers
# RecName	NCKX1_HUMAN	Sodium/potassium/calcium exchanger 1
# RefSeq	NP_001287960	NM_001301031.1. [O60721-3]
# RefSeq	NP_001287961	NM_001301032.1. [O60721-2]
# RefSeq	NP_001287962	NM_001301033.1
# RefSeq	NP_004718	NM_004727.2. [O60721-1]
# RefSeq	XP_005254835	XM_005254778.3. [O60721-1]
# RefSeq	XP_011520521	XM_011522219.1. [O60721-1]
# RefSeq	XP_011520522	XM_011522220.2. [O60721-2]
# RefSeq	XP_011520523	XM_011522221.2. [O60721-3]
# SIMILARITY	Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	NCKX1_HUMAN	Membrane; Multi-pass membrane protein. 
# TCDB	2.A.19.4:the ca(2+)	cation antiporter (caca) family
# TIGRFAMs	TIGR00367	TIGR00367
# TIGRFAMs	TIGR00927	2A1904
# TISSUE SPECIFICITY	Expressed in the retina, particularly in the inner segment, outer and inner nuclear layers, and ganglion cell layer. {ECO:0000269|PubMed	20850105}. 
# UCSC	uc010ujf	human. [O60721-1]
# eggNOG	ENOG410Y9YY	LUCA
# eggNOG	KOG1307	Eukaryota
BLAST	swissprot:NCKX1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NCKX1_HUMAN
BioCyc	ZFISH:ENSG00000074621-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000074621-MONOMER
COXPRESdb	9187	http://coxpresdb.jp/data/gene/9187.shtml
CleanEx	HS_SLC24A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC24A1
DOI	10.1007/s004390050842	http://dx.doi.org/10.1007/s004390050842
DOI	10.1016/j.ajhg.2010.08.013	http://dx.doi.org/10.1016/j.ajhg.2010.08.013
DOI	10.1038/nature04601	http://dx.doi.org/10.1038/nature04601
DOI	10.1074/jbc.274.53.38177	http://dx.doi.org/10.1074/jbc.274.53.38177
DOI	10.1093/dnares/5.3.169	http://dx.doi.org/10.1093/dnares/5.3.169
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
EMBL	AB014602	http://www.ebi.ac.uk/ena/data/view/AB014602
EMBL	AC011939	http://www.ebi.ac.uk/ena/data/view/AC011939
EMBL	AC027220	http://www.ebi.ac.uk/ena/data/view/AC027220
EMBL	AF026132	http://www.ebi.ac.uk/ena/data/view/AF026132
EMBL	AF062921	http://www.ebi.ac.uk/ena/data/view/AF062921
EMBL	AF062922	http://www.ebi.ac.uk/ena/data/view/AF062922
EMBL	BC117263	http://www.ebi.ac.uk/ena/data/view/BC117263
EMBL	BC143375	http://www.ebi.ac.uk/ena/data/view/BC143375
Ensembl	ENST00000261892	http://www.ensembl.org/id/ENST00000261892
Ensembl	ENST00000339868	http://www.ensembl.org/id/ENST00000339868
Ensembl	ENST00000399033	http://www.ensembl.org/id/ENST00000399033
Ensembl	ENST00000546330	http://www.ensembl.org/id/ENST00000546330
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0019867	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019867
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0008273	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008273
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_function	GO:0030955	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030955
GO_function	GO:0031402	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031402
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0006874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874
GO_process	GO:0007601	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007601
GO_process	GO:0009642	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009642
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	SLC24A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC24A1
GeneID	9187	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9187
GeneTree	ENSGT00760000119209	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119209
HGNC	HGNC:10975	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10975
HOGENOM	HOG000231933	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231933&db=HOGENOM6
HOVERGEN	HBG104097	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG104097&db=HOVERGEN
HPA	HPA039370	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA039370
InParanoid	O60721	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O60721
IntAct	O60721	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O60721*
InterPro	IPR004481	http://www.ebi.ac.uk/interpro/entry/IPR004481
InterPro	IPR004817	http://www.ebi.ac.uk/interpro/entry/IPR004817
InterPro	IPR004837	http://www.ebi.ac.uk/interpro/entry/IPR004837
Jabion	9187	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9187
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00787	http://www.genome.jp/dbget-bin/www_bget?H00787
KEGG_Gene	hsa:9187	http://www.genome.jp/dbget-bin/www_bget?hsa:9187
KEGG_Orthology	KO:K13749	http://www.genome.jp/dbget-bin/www_bget?KO:K13749
KEGG_Pathway	ko04744	http://www.genome.jp/kegg-bin/show_pathway?ko04744
MIM	603617	http://www.ncbi.nlm.nih.gov/omim/603617
MIM	613830	http://www.ncbi.nlm.nih.gov/omim/613830
OMA	DQKENPG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DQKENPG
Orphanet	215	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=215
OrthoDB	EOG091G0M5C	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0M5C
PANTHER	PTHR10846	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10846
PSORT	swissprot:NCKX1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NCKX1_HUMAN
PSORT-B	swissprot:NCKX1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NCKX1_HUMAN
PSORT2	swissprot:NCKX1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NCKX1_HUMAN
Pfam	PF01699	http://pfam.xfam.org/family/PF01699
PharmGKB	PA35851	http://www.pharmgkb.org/do/serve?objId=PA35851&objCls=Gene
Phobius	swissprot:NCKX1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NCKX1_HUMAN
PhylomeDB	O60721	http://phylomedb.org/?seqid=O60721
ProteinModelPortal	O60721	http://www.proteinmodelportal.org/query/uniprot/O60721
PubMed	10608890	http://www.ncbi.nlm.nih.gov/pubmed/10608890
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16572171	http://www.ncbi.nlm.nih.gov/pubmed/16572171
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20850105	http://www.ncbi.nlm.nih.gov/pubmed/20850105
PubMed	9478004	http://www.ncbi.nlm.nih.gov/pubmed/9478004
PubMed	9734811	http://www.ncbi.nlm.nih.gov/pubmed/9734811
PubMed	9856482	http://www.ncbi.nlm.nih.gov/pubmed/9856482
Reactome	R-HSA-2485179	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2485179
Reactome	R-HSA-425561	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425561
RefSeq	NP_001287960	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001287960
RefSeq	NP_001287961	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001287961
RefSeq	NP_001287962	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001287962
RefSeq	NP_004718	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004718
RefSeq	XP_005254835	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005254835
RefSeq	XP_011520521	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011520521
RefSeq	XP_011520522	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011520522
RefSeq	XP_011520523	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011520523
SMR	O60721	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O60721
STRING	9606.ENSP00000261892	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000261892&targetmode=cogs
TCDB	2.A.19.4	http://www.tcdb.org/search/result.php?tc=2.A.19.4
TIGRFAMs	TIGR00367	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00367
TIGRFAMs	TIGR00927	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00927
UCSC	uc010ujf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010ujf&org=rat
UniGene	Hs.173092	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.173092
UniGene	Hs.617821	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.617821
UniProtKB	NCKX1_HUMAN	http://www.uniprot.org/uniprot/NCKX1_HUMAN
UniProtKB-AC	O60721	http://www.uniprot.org/uniprot/O60721
charge	swissprot:NCKX1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NCKX1_HUMAN
eggNOG	ENOG410Y9YY	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y9YY
eggNOG	KOG1307	http://eggnogapi.embl.de/nog_data/html/tree/KOG1307
epestfind	swissprot:NCKX1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NCKX1_HUMAN
garnier	swissprot:NCKX1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NCKX1_HUMAN
helixturnhelix	swissprot:NCKX1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NCKX1_HUMAN
hmoment	swissprot:NCKX1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NCKX1_HUMAN
iep	swissprot:NCKX1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NCKX1_HUMAN
inforesidue	swissprot:NCKX1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NCKX1_HUMAN
neXtProt	NX_O60721	http://www.nextprot.org/db/entry/NX_O60721
octanol	swissprot:NCKX1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NCKX1_HUMAN
pepcoil	swissprot:NCKX1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NCKX1_HUMAN
pepdigest	swissprot:NCKX1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NCKX1_HUMAN
pepinfo	swissprot:NCKX1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NCKX1_HUMAN
pepnet	swissprot:NCKX1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NCKX1_HUMAN
pepstats	swissprot:NCKX1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NCKX1_HUMAN
pepwheel	swissprot:NCKX1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NCKX1_HUMAN
pepwindow	swissprot:NCKX1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NCKX1_HUMAN
sigcleave	swissprot:NCKX1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NCKX1_HUMAN
## Database	ID	URL or Descriptions
# AltName	CXB1_HUMAN	Connexin-32
# AltName	CXB1_HUMAN	GAP junction 28 kDa liver protein
# BioGrid	108971	7
# DISEASE	CXB1_HUMAN	Charcot-Marie-Tooth disease, X-linked dominant, 1 (CMTX1) [MIM 302800]  A form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology  primary peripheral demyelinating neuropathies characterized by severely reduced motor nerve conduction velocities (NCVs) (less than 38m/s) and segmental demyelination and remyelination, and primary peripheral axonal neuropathies characterized by normal or mildly reduced NCVs and chronic axonal degeneration and regeneration on nerve biopsy. CMTX1 has both demyelinating and axonal features. Central nervous system involvement may occur. {ECO 0000269|PubMed 10071100, ECO 0000269|PubMed 10220155, ECO 0000269|PubMed 10234007, ECO 0000269|PubMed 10586284, ECO 0000269|PubMed 10732813, ECO 0000269|PubMed 10737979, ECO 0000269|PubMed 10873293, ECO 0000269|PubMed 10894999, ECO 0000269|PubMed 10923043, ECO 0000269|PubMed 10938190, ECO 0000269|PubMed 11030070, ECO 0000269|PubMed 11140841, ECO 0000269|PubMed 11180613, ECO 0000269|PubMed 11437164, ECO 0000269|PubMed 11438991, ECO 0000269|PubMed 11562788, ECO 0000269|PubMed 11571214, ECO 0000269|PubMed 11723288, ECO 0000269|PubMed 11835375, ECO 0000269|PubMed 12185164, ECO 0000269|PubMed 12207932, ECO 0000269|PubMed 12325071, ECO 0000269|PubMed 12402337, ECO 0000269|PubMed 12477701, ECO 0000269|PubMed 12497641, ECO 0000269|PubMed 12536289, ECO 0000269|PubMed 12707076, ECO 0000269|PubMed 14627639, ECO 0000269|PubMed 15241803, ECO 0000269|PubMed 15468313, ECO 0000269|PubMed 15852376, ECO 0000269|PubMed 27234031, ECO 0000269|PubMed 7477983, ECO 0000269|PubMed 7833935, ECO 0000269|PubMed 8004109, ECO 0000269|PubMed 8162049, ECO 0000269|PubMed 8266101, ECO 0000269|PubMed 8628473, ECO 0000269|PubMed 8698335, ECO 0000269|PubMed 8733054, ECO 0000269|PubMed 8737658, ECO 0000269|PubMed 8807343, ECO 0000269|PubMed 8829637, ECO 0000269|PubMed 8889588, ECO 0000269|PubMed 8956046, ECO 0000269|PubMed 8990008, ECO 0000269|PubMed 9018031, ECO 0000269|PubMed 9099841, ECO 0000269|PubMed 9187667, ECO 0000269|PubMed 9272161, ECO 0000269|PubMed 9361298, ECO 0000269|PubMed 9452025, ECO 0000269|PubMed 9452099, ECO 0000269|PubMed 9469569, ECO 0000269|PubMed 9633821, ECO 0000269|PubMed 9818870, ECO 0000269|PubMed 9856562, ECO 0000269|Ref.12}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CXB1_HUMAN	Dejerine-Sottas syndrome (DSS) [MIM 145900]  A severe degenerating neuropathy of the demyelinating Charcot-Marie-Tooth disease category, with onset by age 2 years. Characterized by motor and sensory neuropathy with very slow nerve conduction velocities, increased cerebrospinal fluid protein concentrations, hypertrophic nerve changes, delayed age of walking as well as areflexia. There are both autosomal dominant and autosomal recessive forms of Dejerine-Sottas syndrome. {ECO 0000269|PubMed 15947997}. Note=The gene represented in this entry may act as a disease modifier. 
# Ensembl	ENST00000361726	ENSP00000354900; ENSG00000169562
# Ensembl	ENST00000374022	ENSP00000363134; ENSG00000169562
# Ensembl	ENST00000374029	ENSP00000363141; ENSG00000169562
# ExpressionAtlas	P08034	baseline and differential
# FUNCTION	CXB1_HUMAN	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. 
# GO_component	GO:0005789	endoplasmic reticulum membrane; TAS:Reactome.
# GO_component	GO:0005922	connexin complex; TAS:ProtInc.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005243	gap junction channel activity; TAS:Reactome.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007267	cell-cell signaling; TAS:ProtInc.
# GO_process	GO:0007399	nervous system development; TAS:ProtInc.
# GO_process	GO:0015868	purine ribonucleotide transport; IEA:Ensembl.
# GO_process	GO:0016264	gap junction assembly; TAS:Reactome.
# GO_process	GO:0051259	protein oligomerization; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0022607	cellular component assembly
# GOslim_process	GO:0034330	cell junction organization
# GOslim_process	GO:0048856	anatomical structure development
# Genevisible	P08034	HS
# HGNC	HGNC:4283	GJB1
# InterPro	IPR000500	Connexin
# InterPro	IPR002267	Connexin32
# InterPro	IPR013092	Connexin_N
# InterPro	IPR017990	Connexin_CS
# InterPro	IPR019570	Connexin_CCC
# KEGG_Disease	H00264	[Neurodegenerative disease] Peroneal muscular atrophy
# MIM	145900	phenotype
# MIM	302800	phenotype
# MIM	304040	gene
# Organism	CXB1_HUMAN	Homo sapiens (Human)
# Orphanet	101075	X-linked Charcot-Marie-Tooth disease type 1
# Orphanet	1175	X-linked progressive cerebellar ataxia
# PANTHER	PTHR11984	PTHR11984
# PDB	1TXH	Model; -; A/B/C/D/E/F=19-209
# PDB	5KK9	NMR; -; A=1-22
# PIR	B29005	B29005
# PRINTS	PR00206	CONNEXIN
# PRINTS	PR01138	CONNEXINB1
# PROSITE	PS00407	CONNEXINS_1
# PROSITE	PS00408	CONNEXINS_2
# Pfam	PF00029	Connexin
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-190704	Oligomerization of connexins into connexons
# Reactome	R-HSA-190827	Transport of connexins along the secretory pathway
# Reactome	R-HSA-190861	Gap junction assembly
# RecName	CXB1_HUMAN	Gap junction beta-1 protein
# RefSeq	NP_000157	NM_000166.5
# RefSeq	NP_001091111	NM_001097642.2
# RefSeq	XP_011529209	XM_011530907.2
# RefSeq	XP_016884897	XM_017029408.1
# SIMILARITY	Belongs to the connexin family. Beta-type (group I) subfamily. {ECO	0000305}. 
# SMART	SM00037	CNX
# SMART	SM01089	Connexin_CCC
# SUBCELLULAR LOCATION	CXB1_HUMAN	Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. 
# SUBUNIT	A connexon is composed of a hexamer of connexins. Interacts with CNST (By similarity). {ECO	0000250}. 
# TCDB	1.A.24.1	the gap junction-forming connexin (connexin) family
# UCSC	uc004dzf	human
# WEB RESOURCE	CXB1_HUMAN	Name=Connexin-deafness homepage; URL="http //davinci.crg.es/deafness/";
# WEB RESOURCE	CXB1_HUMAN	Name=Inherited peripheral neuropathies mutation db; URL="http //www.molgen.ua.ac.be/CMTMutations/"; 
# eggNOG	ENOG410IFM8	Eukaryota
# eggNOG	ENOG410Y7VN	LUCA
BLAST	swissprot:CXB1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CXB1_HUMAN
BioCyc	ZFISH:ENSG00000169562-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000169562-MONOMER
COXPRESdb	2705	http://coxpresdb.jp/data/gene/2705.shtml
CleanEx	HS_GJB1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GJB1
DOI	10.1001/archneur.60.4.605	http://dx.doi.org/10.1001/archneur.60.4.605
DOI	10.1002/(SICI)1096-8628(19960614)63:3<486::AID-AJMG14>3.0.CO	http://dx.doi.org/10.1002/(SICI)1096-8628(19960614)63:3<486::AID-AJMG14>3.0.CO
DOI	10.1002/(SICI)1096-8628(19981204)80:4<352::AID-AJMG9>3.0.CO	http://dx.doi.org/10.1002/(SICI)1096-8628(19981204)80:4<352::AID-AJMG9>3.0.CO
DOI	10.1002/(SICI)1097-4547(19980115)51:2<154::AID-JNR4>3.0.CO	http://dx.doi.org/10.1002/(SICI)1097-4547(19980115)51:2<154::AID-JNR4>3.0.CO
DOI	10.1002/(SICI)1098-1004(1996)7:2<167::AID-HUMU14>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1996)7:2<167::AID-HUMU14>3.0.CO
DOI	10.1002/(SICI)1098-1004(1996)8:1<83::AID-HUMU14>3.3.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1996)8:1<83::AID-HUMU14>3.3.CO
DOI	10.1002/(SICI)1098-1004(1996)8:3<270::AID-HUMU12>3.3.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1996)8:3<270::AID-HUMU12>3.3.CO
DOI	10.1002/(SICI)1098-1004(1996)8:4<375::AID-HUMU14>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1996)8:4<375::AID-HUMU14>3.0.CO
DOI	10.1002/(SICI)1098-1004(1997)10:6<443::AID-HUMU5>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1997)10:6<443::AID-HUMU5>3.0.CO
DOI	10.1002/(SICI)1098-1004(1997)9:1<47::AID-HUMU8>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1997)9:1<47::AID-HUMU8>3.0.CO
DOI	10.1002/(SICI)1098-1004(1998)12:1<59::AID-HUMU9>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1998)12:1<59::AID-HUMU9>3.0.CO
DOI	10.1002/(SICI)1098-1004(1999)13:1<11::AID-HUMU2>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1999)13:1<11::AID-HUMU2>3.0.CO
DOI	10.1002/(SICI)1098-1004(1999)13:4<339::AID-HUMU18>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1999)13:4<339::AID-HUMU18>3.0.CO
DOI	10.1002/(SICI)1098-1004(200004)15:4<340::AID-HUMU6>3.3.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(200004)15:4<340::AID-HUMU6>3.3.CO
DOI	10.1002/1098-1004(200008)16:2<177::AID-HUMU14>3.0.CO	http://dx.doi.org/10.1002/1098-1004(200008)16:2<177::AID-HUMU14>3.0.CO
DOI	10.1002/1098-1004(200102)17:2<157::AID-HUMU22>3.0.CO	http://dx.doi.org/10.1002/1098-1004(200102)17:2<157::AID-HUMU22>3.0.CO
DOI	10.1002/ana.10089	http://dx.doi.org/10.1002/ana.10089
DOI	10.1002/ana.10305	http://dx.doi.org/10.1002/ana.10305
DOI	10.1002/ana.20459	http://dx.doi.org/10.1002/ana.20459
DOI	10.1002/humu.10134	http://dx.doi.org/10.1002/humu.10134
DOI	10.1002/humu.1147	http://dx.doi.org/10.1002/humu.1147
DOI	10.1002/humu.9101	http://dx.doi.org/10.1002/humu.9101
DOI	10.1002/humu.9261	http://dx.doi.org/10.1002/humu.9261
DOI	10.1002/mus.20166	http://dx.doi.org/10.1002/mus.20166
DOI	10.1006/cbir.1998.0387	http://dx.doi.org/10.1006/cbir.1998.0387
DOI	10.1006/nbdi.1997.0152	http://dx.doi.org/10.1006/nbdi.1997.0152
DOI	10.1006/nbdi.2002.0545	http://dx.doi.org/10.1006/nbdi.2002.0545
DOI	10.1007/s004150170183	http://dx.doi.org/10.1007/s004150170183
DOI	10.1007/s004390050183	http://dx.doi.org/10.1007/s004390050183
DOI	10.1007/s004390050396	http://dx.doi.org/10.1007/s004390050396
DOI	10.1007/s004390050442	http://dx.doi.org/10.1007/s004390050442
DOI	10.1007/s004390050522	http://dx.doi.org/10.1007/s004390050522
DOI	10.1007/s10048-005-0217-4	http://dx.doi.org/10.1007/s10048-005-0217-4
DOI	10.1007/s100480050017	http://dx.doi.org/10.1007/s100480050017
DOI	10.1007/s100720070105	http://dx.doi.org/10.1007/s100720070105
DOI	10.1007/s100720200061	http://dx.doi.org/10.1007/s100720200061
DOI	10.1016/S0960-8966(02)00021-4	http://dx.doi.org/10.1016/S0960-8966(02)00021-4
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.molcel.2004.08.016	http://dx.doi.org/10.1016/j.molcel.2004.08.016
DOI	10.1034/j.1399-0004.2000.580511.x	http://dx.doi.org/10.1034/j.1399-0004.2000.580511.x
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1053/ejpn.2000.0311	http://dx.doi.org/10.1053/ejpn.2000.0311
DOI	10.1073/pnas.261713499	http://dx.doi.org/10.1073/pnas.261713499
DOI	10.1083/jcb.103.3.767	http://dx.doi.org/10.1083/jcb.103.3.767
DOI	10.1093/brain/124.10.1958	http://dx.doi.org/10.1093/brain/124.10.1958
DOI	10.1093/brain/awg012	http://dx.doi.org/10.1093/brain/awg012
DOI	10.1093/hmg/3.1.29	http://dx.doi.org/10.1093/hmg/3.1.29
DOI	10.1093/hmg/3.2.355	http://dx.doi.org/10.1093/hmg/3.2.355
DOI	10.1093/hmg/3.9.1699	http://dx.doi.org/10.1093/hmg/3.9.1699
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/cge.12810	http://dx.doi.org/10.1111/cge.12810
DOI	10.1111/j.1749-6632.1999.tb08621.x	http://dx.doi.org/10.1111/j.1749-6632.1999.tb08621.x
DOI	10.1126/science.8266101	http://dx.doi.org/10.1126/science.8266101
DOI	10.1136/jmg.33.5.413	http://dx.doi.org/10.1136/jmg.33.5.413
DOI	10.1136/jnnp.66.2.202	http://dx.doi.org/10.1136/jnnp.66.2.202
DOI	10.1136/jnnp.73.3.304	http://dx.doi.org/10.1136/jnnp.73.3.304
DOI	10.1159/000008196	http://dx.doi.org/10.1159/000008196
DOI	10.1212/WNL.45.10.1863	http://dx.doi.org/10.1212/WNL.45.10.1863
DOI	10.1212/WNL.46.5.1311	http://dx.doi.org/10.1212/WNL.46.5.1311
DOI	10.1212/WNL.51.5.1412	http://dx.doi.org/10.1212/WNL.51.5.1412
DOI	10.1212/WNL.57.10.1906	http://dx.doi.org/10.1212/WNL.57.10.1906
EMBL	AK313474	http://www.ebi.ac.uk/ena/data/view/AK313474
EMBL	BC002805	http://www.ebi.ac.uk/ena/data/view/BC002805
EMBL	BC022426	http://www.ebi.ac.uk/ena/data/view/BC022426
EMBL	BC039198	http://www.ebi.ac.uk/ena/data/view/BC039198
EMBL	BT019329	http://www.ebi.ac.uk/ena/data/view/BT019329
EMBL	CH471132	http://www.ebi.ac.uk/ena/data/view/CH471132
EMBL	CH471132	http://www.ebi.ac.uk/ena/data/view/CH471132
EMBL	L47127	http://www.ebi.ac.uk/ena/data/view/L47127
EMBL	X04325	http://www.ebi.ac.uk/ena/data/view/X04325
Ensembl	ENST00000361726	http://www.ensembl.org/id/ENST00000361726
Ensembl	ENST00000374022	http://www.ensembl.org/id/ENST00000374022
Ensembl	ENST00000374029	http://www.ensembl.org/id/ENST00000374029
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005922	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005922
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005243	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005243
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GO_process	GO:0007399	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007399
GO_process	GO:0015868	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015868
GO_process	GO:0016264	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016264
GO_process	GO:0051259	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051259
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0022607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607
GOslim_process	GO:0034330	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034330
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GeneCards	GJB1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GJB1
GeneID	2705	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2705
GeneTree	ENSGT00860000133694	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00860000133694
HGNC	HGNC:4283	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4283
HOGENOM	HOG000231127	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231127&db=HOGENOM6
HOVERGEN	HBG009576	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG009576&db=HOVERGEN
HPA	CAB012994	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB012994
HPA	HPA010663	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA010663
InParanoid	P08034	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08034
InterPro	IPR000500	http://www.ebi.ac.uk/interpro/entry/IPR000500
InterPro	IPR002267	http://www.ebi.ac.uk/interpro/entry/IPR002267
InterPro	IPR013092	http://www.ebi.ac.uk/interpro/entry/IPR013092
InterPro	IPR017990	http://www.ebi.ac.uk/interpro/entry/IPR017990
InterPro	IPR019570	http://www.ebi.ac.uk/interpro/entry/IPR019570
Jabion	2705	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2705
KEGG_Disease	H00264	http://www.genome.jp/dbget-bin/www_bget?H00264
KEGG_Gene	hsa:2705	http://www.genome.jp/dbget-bin/www_bget?hsa:2705
KEGG_Orthology	KO:K07620	http://www.genome.jp/dbget-bin/www_bget?KO:K07620
MIM	145900	http://www.ncbi.nlm.nih.gov/omim/145900
MIM	302800	http://www.ncbi.nlm.nih.gov/omim/302800
MIM	304040	http://www.ncbi.nlm.nih.gov/omim/304040
OMA	YLVVRAC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YLVVRAC
Orphanet	101075	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=101075
Orphanet	1175	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1175
OrthoDB	EOG091G0FKH	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0FKH
PANTHER	PTHR11984	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11984
PDB	1TXH	http://www.ebi.ac.uk/pdbe-srv/view/entry/1TXH
PDB	5KK9	http://www.ebi.ac.uk/pdbe-srv/view/entry/5KK9
PDBsum	1TXH	http://www.ebi.ac.uk/pdbsum/1TXH
PDBsum	5KK9	http://www.ebi.ac.uk/pdbsum/5KK9
PRINTS	PR00206	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00206
PRINTS	PR01138	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01138
PROSITE	PS00407	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00407
PROSITE	PS00408	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00408
PSORT	swissprot:CXB1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CXB1_HUMAN
PSORT-B	swissprot:CXB1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CXB1_HUMAN
PSORT2	swissprot:CXB1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CXB1_HUMAN
Pfam	PF00029	http://pfam.xfam.org/family/PF00029
PharmGKB	PA28694	http://www.pharmgkb.org/do/serve?objId=PA28694&objCls=Gene
Phobius	swissprot:CXB1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CXB1_HUMAN
PhylomeDB	P08034	http://phylomedb.org/?seqid=P08034
ProteinModelPortal	P08034	http://www.proteinmodelportal.org/query/uniprot/P08034
PubMed	10071100	http://www.ncbi.nlm.nih.gov/pubmed/10071100
PubMed	10220155	http://www.ncbi.nlm.nih.gov/pubmed/10220155
PubMed	10234007	http://www.ncbi.nlm.nih.gov/pubmed/10234007
PubMed	10586284	http://www.ncbi.nlm.nih.gov/pubmed/10586284
PubMed	10732813	http://www.ncbi.nlm.nih.gov/pubmed/10732813
PubMed	10737979	http://www.ncbi.nlm.nih.gov/pubmed/10737979
PubMed	10873293	http://www.ncbi.nlm.nih.gov/pubmed/10873293
PubMed	10894999	http://www.ncbi.nlm.nih.gov/pubmed/10894999
PubMed	10923043	http://www.ncbi.nlm.nih.gov/pubmed/10923043
PubMed	10938190	http://www.ncbi.nlm.nih.gov/pubmed/10938190
PubMed	11030070	http://www.ncbi.nlm.nih.gov/pubmed/11030070
PubMed	11140841	http://www.ncbi.nlm.nih.gov/pubmed/11140841
PubMed	11180613	http://www.ncbi.nlm.nih.gov/pubmed/11180613
PubMed	11437164	http://www.ncbi.nlm.nih.gov/pubmed/11437164
PubMed	11438991	http://www.ncbi.nlm.nih.gov/pubmed/11438991
PubMed	11562788	http://www.ncbi.nlm.nih.gov/pubmed/11562788
PubMed	11571214	http://www.ncbi.nlm.nih.gov/pubmed/11571214
PubMed	11723288	http://www.ncbi.nlm.nih.gov/pubmed/11723288
PubMed	11835375	http://www.ncbi.nlm.nih.gov/pubmed/11835375
PubMed	11891346	http://www.ncbi.nlm.nih.gov/pubmed/11891346
PubMed	12185164	http://www.ncbi.nlm.nih.gov/pubmed/12185164
PubMed	12207932	http://www.ncbi.nlm.nih.gov/pubmed/12207932
PubMed	12325071	http://www.ncbi.nlm.nih.gov/pubmed/12325071
PubMed	12402337	http://www.ncbi.nlm.nih.gov/pubmed/12402337
PubMed	12460545	http://www.ncbi.nlm.nih.gov/pubmed/12460545
PubMed	12477701	http://www.ncbi.nlm.nih.gov/pubmed/12477701
PubMed	12497641	http://www.ncbi.nlm.nih.gov/pubmed/12497641
PubMed	12536289	http://www.ncbi.nlm.nih.gov/pubmed/12536289
PubMed	12707076	http://www.ncbi.nlm.nih.gov/pubmed/12707076
PubMed	14627639	http://www.ncbi.nlm.nih.gov/pubmed/14627639
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15241803	http://www.ncbi.nlm.nih.gov/pubmed/15241803
PubMed	15383278	http://www.ncbi.nlm.nih.gov/pubmed/15383278
PubMed	15468313	http://www.ncbi.nlm.nih.gov/pubmed/15468313
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15852376	http://www.ncbi.nlm.nih.gov/pubmed/15852376
PubMed	15947997	http://www.ncbi.nlm.nih.gov/pubmed/15947997
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	2460334	http://www.ncbi.nlm.nih.gov/pubmed/2460334
PubMed	27234031	http://www.ncbi.nlm.nih.gov/pubmed/27234031
PubMed	2875078	http://www.ncbi.nlm.nih.gov/pubmed/2875078
PubMed	7477983	http://www.ncbi.nlm.nih.gov/pubmed/7477983
PubMed	7833935	http://www.ncbi.nlm.nih.gov/pubmed/7833935
PubMed	8004109	http://www.ncbi.nlm.nih.gov/pubmed/8004109
PubMed	8162049	http://www.ncbi.nlm.nih.gov/pubmed/8162049
PubMed	8266101	http://www.ncbi.nlm.nih.gov/pubmed/8266101
PubMed	8628473	http://www.ncbi.nlm.nih.gov/pubmed/8628473
PubMed	8698335	http://www.ncbi.nlm.nih.gov/pubmed/8698335
PubMed	8733054	http://www.ncbi.nlm.nih.gov/pubmed/8733054
PubMed	8737658	http://www.ncbi.nlm.nih.gov/pubmed/8737658
PubMed	8807343	http://www.ncbi.nlm.nih.gov/pubmed/8807343
PubMed	8829637	http://www.ncbi.nlm.nih.gov/pubmed/8829637
PubMed	8889588	http://www.ncbi.nlm.nih.gov/pubmed/8889588
PubMed	8956046	http://www.ncbi.nlm.nih.gov/pubmed/8956046
PubMed	8990008	http://www.ncbi.nlm.nih.gov/pubmed/8990008
PubMed	9018031	http://www.ncbi.nlm.nih.gov/pubmed/9018031
PubMed	9099841	http://www.ncbi.nlm.nih.gov/pubmed/9099841
PubMed	9187667	http://www.ncbi.nlm.nih.gov/pubmed/9187667
PubMed	9272161	http://www.ncbi.nlm.nih.gov/pubmed/9272161
PubMed	9361298	http://www.ncbi.nlm.nih.gov/pubmed/9361298
PubMed	9401007	http://www.ncbi.nlm.nih.gov/pubmed/9401007
PubMed	9452025	http://www.ncbi.nlm.nih.gov/pubmed/9452025
PubMed	9452099	http://www.ncbi.nlm.nih.gov/pubmed/9452099
PubMed	9469569	http://www.ncbi.nlm.nih.gov/pubmed/9469569
PubMed	9633821	http://www.ncbi.nlm.nih.gov/pubmed/9633821
PubMed	9818870	http://www.ncbi.nlm.nih.gov/pubmed/9818870
PubMed	9856562	http://www.ncbi.nlm.nih.gov/pubmed/9856562
PubMed	9888385	http://www.ncbi.nlm.nih.gov/pubmed/9888385
Reactome	R-HSA-190704	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-190704
Reactome	R-HSA-190827	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-190827
Reactome	R-HSA-190861	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-190861
RefSeq	NP_000157	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000157
RefSeq	NP_001091111	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001091111
RefSeq	XP_011529209	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011529209
RefSeq	XP_016884897	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016884897
SMART	SM00037	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00037
SMART	SM01089	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01089
STRING	9606.ENSP00000354900	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000354900&targetmode=cogs
TCDB	1.A.24.1	http://www.tcdb.org/search/result.php?tc=1.A.24.1
UCSC	uc004dzf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004dzf&org=rat
UniGene	Hs.333303	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.333303
UniProtKB	CXB1_HUMAN	http://www.uniprot.org/uniprot/CXB1_HUMAN
UniProtKB-AC	P08034	http://www.uniprot.org/uniprot/P08034
charge	swissprot:CXB1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CXB1_HUMAN
eggNOG	ENOG410IFM8	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IFM8
eggNOG	ENOG410Y7VN	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y7VN
epestfind	swissprot:CXB1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CXB1_HUMAN
garnier	swissprot:CXB1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CXB1_HUMAN
helixturnhelix	swissprot:CXB1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CXB1_HUMAN
hmoment	swissprot:CXB1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CXB1_HUMAN
iep	swissprot:CXB1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CXB1_HUMAN
inforesidue	swissprot:CXB1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CXB1_HUMAN
neXtProt	NX_P08034	http://www.nextprot.org/db/entry/NX_P08034
octanol	swissprot:CXB1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CXB1_HUMAN
pepcoil	swissprot:CXB1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CXB1_HUMAN
pepdigest	swissprot:CXB1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CXB1_HUMAN
pepinfo	swissprot:CXB1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CXB1_HUMAN
pepnet	swissprot:CXB1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CXB1_HUMAN
pepstats	swissprot:CXB1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CXB1_HUMAN
pepwheel	swissprot:CXB1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CXB1_HUMAN
pepwindow	swissprot:CXB1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CXB1_HUMAN
sigcleave	swissprot:CXB1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CXB1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GTR4_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P14672-1; Sequence=Displayed; Name=2; IsoId=P14672-2; Sequence=VSP_056331, VSP_056332; Note=No experimental confirmation available.; 
# AltName	GTR4_HUMAN	Glucose transporter type 4, insulin-responsive
# BioGrid	112408	39
# CCDS	CCDS11097	-. [P14672-1]
# CDD	cd06174	MFS
# DISEASE	GTR4_HUMAN	Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM 125853]  A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO 0000269|PubMed 1521731, ECO 0000269|PubMed 1756912, ECO 0000269|PubMed 1918382}. Note=The disease may be caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000317370	ENSP00000320935; ENSG00000181856. [P14672-1]
# Ensembl	ENST00000572485	ENSP00000461086; ENSG00000181856. [P14672-2]
# ExpressionAtlas	P14672	baseline and differential
# FUNCTION	GTR4_HUMAN	Insulin-regulated facilitative glucose transporter. 
# GO_component	GO:0005771	multivesicular body; IEA:Ensembl.
# GO_component	GO:0005829	cytosol; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0005905	clathrin-coated pit; IEA:Ensembl.
# GO_component	GO:0009897	external side of plasma membrane; IDA:MGI.
# GO_component	GO:0012505	endomembrane system; ISS:UniProtKB.
# GO_component	GO:0012506	vesicle membrane; IDA:MGI.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0030136	clathrin-coated vesicle; IDA:UniProtKB.
# GO_component	GO:0030140	trans-Golgi network transport vesicle; IEA:Ensembl.
# GO_component	GO:0030315	T-tubule; IEA:Ensembl.
# GO_component	GO:0030659	cytoplasmic vesicle membrane; IEA:Ensembl.
# GO_component	GO:0032593	insulin-responsive compartment; IDA:UniProtKB.
# GO_component	GO:0045121	membrane raft; IEA:Ensembl.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IEA:Ensembl.
# GO_function	GO:0005355	glucose transmembrane transporter activity; EXP:Reactome.
# GO_function	GO:0055056	D-glucose transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0005975	carbohydrate metabolic process; TAS:ProtInc.
# GO_process	GO:0010021	amylopectin biosynthetic process; IEA:Ensembl.
# GO_process	GO:0015758	glucose transport; TAS:UniProtKB.
# GO_process	GO:0032869	cellular response to insulin stimulus; IDA:UniProtKB.
# GO_process	GO:0042593	glucose homeostasis; IDA:BHF-UCL.
# GO_process	GO:0045471	response to ethanol; IEA:Ensembl.
# GO_process	GO:0046323	glucose import; NAS:BHF-UCL.
# GO_process	GO:0050873	brown fat cell differentiation; IEA:Ensembl.
# GO_process	GO:0071356	cellular response to tumor necrosis factor; IEA:Ensembl.
# GO_process	GO:0071456	cellular response to hypoxia; IEA:Ensembl.
# GO_process	GO:0071470	cellular response to osmotic stress; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0005975	carbohydrate metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0042592	homeostatic process
# Genevisible	P14672	HS
# HGNC	HGNC:11009	SLC2A4
# IntAct	P14672	2
# InterPro	IPR002441	Glc_transpt_4
# InterPro	IPR003663	Sugar/inositol_transpt
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR005829	Sugar_transporter_CS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04910	Insulin signaling pathway
# KEGG_Pathway	ko04920	Adipocytokine signaling pathway
# KEGG_Pathway	ko04930	Type II diabetes mellitus
# MIM	125853	phenotype
# MIM	138190	gene
# MISCELLANEOUS	Insulin-stimulated phosphorylation of TBC1D4 is required for GLUT4 translocation. {ECO	0000250}. 
# Organism	GTR4_HUMAN	Homo sapiens (Human)
# PIR	A49158	A33801
# PRINTS	PR00171	SUGRTRNSPORT
# PRINTS	PR01193	GLUCTRSPORT4
# PROSITE	PS00216	SUGAR_TRANSPORT_1
# PROSITE	PS00217	SUGAR_TRANSPORT_2
# PROSITE	PS50850	MFS
# PTM	GTR4_HUMAN	Sumoylated. {ECO 0000269|PubMed 11842083}. 
# Pfam	PF00083	Sugar_tr
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-1445148	Translocation of GLUT4 to the plasma membrane
# Reactome	R-HSA-381340	Transcriptional regulation of white adipocyte differentiation
# Reactome	R-HSA-428790	Facilitative Na+-independent glucose transporters
# Reactome	R-HSA-70153	Glucose transport
# RecName	GTR4_HUMAN	Solute carrier family 2, facilitated glucose transporter member 4
# RefSeq	NP_001033	NM_001042.2. [P14672-1]
# SIMILARITY	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	GTR4_HUMAN	Cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Endomembrane system {ECO 0000269|PubMed 8300557}; Multi-pass membrane protein {ECO 0000269|PubMed 8300557}. Cytoplasm, perinuclear region {ECO 0000269|PubMed 8300557}. Note=Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized. The dileucine internalization motif is critical for intracellular sequestration. 
# SUBUNIT	GTR4_HUMAN	Interacts with NDUFA9 (By similarity). Binds to DAXX. Interacts via its N-terminus with SRFBP1. {ECO 0000250, ECO 0000269|PubMed 11842083, ECO 0000269|PubMed 16647043}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.1.80	the major facilitator superfamily (mfs)
# TIGRFAMs	TIGR00879	SP
# TISSUE SPECIFICITY	GTR4_HUMAN	Skeletal and cardiac muscles; brown and white fat. 
# UCSC	uc002gfp	human. [P14672-1]
# WEB RESOURCE	GTR4_HUMAN	Name=Wikipedia; Note=GLUT4 entry; URL="https //en.wikipedia.org/wiki/Glut4";
# eggNOG	COG0477	LUCA
# eggNOG	KOG0569	Eukaryota
BLAST	swissprot:GTR4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GTR4_HUMAN
BioCyc	ZFISH:ENSG00000181856-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000181856-MONOMER
COXPRESdb	6517	http://coxpresdb.jp/data/gene/6517.shtml
CleanEx	HS_SLC2A4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC2A4
DOI	10.1007/BF02342449	http://dx.doi.org/10.1007/BF02342449
DOI	10.1016/0378-1119(93)90438-9	http://dx.doi.org/10.1016/0378-1119(93)90438-9
DOI	10.1016/j.bbrc.2006.04.017	http://dx.doi.org/10.1016/j.bbrc.2006.04.017
DOI	10.1016/j.bbrc.2007.03.029	http://dx.doi.org/10.1016/j.bbrc.2007.03.029
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1038/nbt.1532	http://dx.doi.org/10.1038/nbt.1532
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/jbc.M110294200	http://dx.doi.org/10.1074/jbc.M110294200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1172/JCI115437	http://dx.doi.org/10.1172/JCI115437
DOI	10.2337/diab.40.12.1712	http://dx.doi.org/10.2337/diab.40.12.1712
DOI	10.2337/diab.41.11.1436	http://dx.doi.org/10.2337/diab.41.11.1436
EMBL	AC003688	http://www.ebi.ac.uk/ena/data/view/AC003688
EMBL	BC034387	http://www.ebi.ac.uk/ena/data/view/BC034387
EMBL	BC069615	http://www.ebi.ac.uk/ena/data/view/BC069615
EMBL	BC069621	http://www.ebi.ac.uk/ena/data/view/BC069621
EMBL	BC113592	http://www.ebi.ac.uk/ena/data/view/BC113592
EMBL	BC126164	http://www.ebi.ac.uk/ena/data/view/BC126164
EMBL	M20747	http://www.ebi.ac.uk/ena/data/view/M20747
EMBL	M91463	http://www.ebi.ac.uk/ena/data/view/M91463
EMBL	X58489	http://www.ebi.ac.uk/ena/data/view/X58489
Ensembl	ENST00000317370	http://www.ensembl.org/id/ENST00000317370
Ensembl	ENST00000572485	http://www.ensembl.org/id/ENST00000572485
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005771	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005771
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005905	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005905
GO_component	GO:0009897	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009897
GO_component	GO:0012505	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0012505
GO_component	GO:0012506	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0012506
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0030136	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030136
GO_component	GO:0030140	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030140
GO_component	GO:0030315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030315
GO_component	GO:0030659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030659
GO_component	GO:0032593	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032593
GO_component	GO:0045121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045121
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005355	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005355
GO_function	GO:0055056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055056
GO_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GO_process	GO:0010021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010021
GO_process	GO:0015758	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015758
GO_process	GO:0032869	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032869
GO_process	GO:0042593	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042593
GO_process	GO:0045471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045471
GO_process	GO:0046323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046323
GO_process	GO:0050873	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050873
GO_process	GO:0071356	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071356
GO_process	GO:0071456	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071456
GO_process	GO:0071470	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071470
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GeneCards	SLC2A4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC2A4
GeneID	6517	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6517
GeneTree	ENSGT00760000119022	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119022
HGNC	HGNC:11009	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11009
HOGENOM	HOG000202871	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202871&db=HOGENOM6
HOVERGEN	HBG014816	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG014816&db=HOVERGEN
HPA	CAB016544	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB016544
InParanoid	P14672	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P14672
IntAct	P14672	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P14672*
InterPro	IPR002441	http://www.ebi.ac.uk/interpro/entry/IPR002441
InterPro	IPR003663	http://www.ebi.ac.uk/interpro/entry/IPR003663
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR005829	http://www.ebi.ac.uk/interpro/entry/IPR005829
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	6517	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6517
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6517	http://www.genome.jp/dbget-bin/www_bget?hsa:6517
KEGG_Orthology	KO:K07191	http://www.genome.jp/dbget-bin/www_bget?KO:K07191
KEGG_Pathway	ko04910	http://www.genome.jp/kegg-bin/show_pathway?ko04910
KEGG_Pathway	ko04920	http://www.genome.jp/kegg-bin/show_pathway?ko04920
KEGG_Pathway	ko04930	http://www.genome.jp/kegg-bin/show_pathway?ko04930
MIM	125853	http://www.ncbi.nlm.nih.gov/omim/125853
MIM	138190	http://www.ncbi.nlm.nih.gov/omim/138190
MINT	MINT-232088	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-232088
OMA	SHTHRQP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SHTHRQP
OrthoDB	EOG091G0A9K	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0A9K
PRINTS	PR00171	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00171
PRINTS	PR01193	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01193
PROSITE	PS00216	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00216
PROSITE	PS00217	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00217
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:GTR4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GTR4_HUMAN
PSORT-B	swissprot:GTR4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GTR4_HUMAN
PSORT2	swissprot:GTR4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GTR4_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
PharmGKB	PA35879	http://www.pharmgkb.org/do/serve?objId=PA35879&objCls=Gene
Phobius	swissprot:GTR4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GTR4_HUMAN
PhylomeDB	P14672	http://phylomedb.org/?seqid=P14672
ProteinModelPortal	P14672	http://www.proteinmodelportal.org/query/uniprot/P14672
PubMed	11842083	http://www.ncbi.nlm.nih.gov/pubmed/11842083
PubMed	1397719	http://www.ncbi.nlm.nih.gov/pubmed/1397719
PubMed	1521731	http://www.ncbi.nlm.nih.gov/pubmed/1521731
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	16647043	http://www.ncbi.nlm.nih.gov/pubmed/16647043
PubMed	17382906	http://www.ncbi.nlm.nih.gov/pubmed/17382906
PubMed	1756912	http://www.ncbi.nlm.nih.gov/pubmed/1756912
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	1918382	http://www.ncbi.nlm.nih.gov/pubmed/1918382
PubMed	19349973	http://www.ncbi.nlm.nih.gov/pubmed/19349973
PubMed	2656669	http://www.ncbi.nlm.nih.gov/pubmed/2656669
PubMed	7916714	http://www.ncbi.nlm.nih.gov/pubmed/7916714
PubMed	8300557	http://www.ncbi.nlm.nih.gov/pubmed/8300557
Reactome	R-HSA-1445148	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1445148
Reactome	R-HSA-381340	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-381340
Reactome	R-HSA-428790	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428790
Reactome	R-HSA-70153	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-70153
RefSeq	NP_001033	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001033
STRING	9606.ENSP00000320935	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000320935&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.1.80	http://www.tcdb.org/search/result.php?tc=2.A.1.1.80
TIGRFAMs	TIGR00879	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00879
UCSC	uc002gfp	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002gfp&org=rat
UniGene	Hs.380691	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.380691
UniProtKB	GTR4_HUMAN	http://www.uniprot.org/uniprot/GTR4_HUMAN
UniProtKB-AC	P14672	http://www.uniprot.org/uniprot/P14672
charge	swissprot:GTR4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GTR4_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG0569	http://eggnogapi.embl.de/nog_data/html/tree/KOG0569
epestfind	swissprot:GTR4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GTR4_HUMAN
garnier	swissprot:GTR4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GTR4_HUMAN
helixturnhelix	swissprot:GTR4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GTR4_HUMAN
hmoment	swissprot:GTR4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GTR4_HUMAN
iep	swissprot:GTR4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GTR4_HUMAN
inforesidue	swissprot:GTR4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GTR4_HUMAN
neXtProt	NX_P14672	http://www.nextprot.org/db/entry/NX_P14672
octanol	swissprot:GTR4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GTR4_HUMAN
pepcoil	swissprot:GTR4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GTR4_HUMAN
pepdigest	swissprot:GTR4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GTR4_HUMAN
pepinfo	swissprot:GTR4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GTR4_HUMAN
pepnet	swissprot:GTR4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GTR4_HUMAN
pepstats	swissprot:GTR4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GTR4_HUMAN
pepwheel	swissprot:GTR4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GTR4_HUMAN
pepwindow	swissprot:GTR4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GTR4_HUMAN
sigcleave	swissprot:GTR4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GTR4_HUMAN
## Database	ID	URL or Descriptions
# AltName	TIM22_HUMAN	Testis-expressed sequence 4
# BioGrid	118969	3
# Ensembl	ENST00000327158	ENSP00000320236; ENSG00000177370
# Ensembl	ENST00000613269	ENSP00000482204; ENSG00000278501
# Ensembl	ENST00000617832	ENSP00000478463; ENSG00000277649
# FUNCTION	TIM22_HUMAN	Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). {ECO 0000250}. 
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:BHF-UCL.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0042721	mitochondrial inner membrane protein insertion complex; IBA:GO_Central.
# GO_function	GO:0015266	protein channel activity; TAS:BHF-UCL.
# GO_function	GO:0030943	mitochondrion targeting sequence binding; IBA:GO_Central.
# GO_process	GO:0006626	protein targeting to mitochondrion; TAS:Reactome.
# GO_process	GO:0045039	protein import into mitochondrial inner membrane; TAS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006605	protein targeting
# GOslim_process	GO:0007005	mitochondrion organization
# GOslim_process	GO:0055085	transmembrane transport
# GOslim_process	GO:0061024	membrane organization
# Genevisible	Q9Y584	HS
# HGNC	HGNC:17317	TIMM22
# IntAct	Q9Y584	4
# InterPro	IPR003397	Tim17/Tim22/Tim23/PMP24
# MIM	607251	gene
# Organism	TIM22_HUMAN	Homo sapiens (Human)
# Pfam	PF02466	Tim17
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-1268020	Mitochondrial protein import
# RecName	TIM22_HUMAN	Mitochondrial import inner membrane translocase subunit Tim22
# RefSeq	NP_037469	NM_013337.3
# SIMILARITY	Belongs to the Tim17/Tim22/Tim23 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	TIM22_HUMAN	Mitochondrion inner membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUBUNIT	Component of the TIM22 complex, whose core is composed of TIMM22, associated with peripheral protein FXC1/TIM10B and the 70 kDa heterohexamer. In most cases, the 70 kDa complex is composed of TIMM9 and TIMM10. A small fraction of the 70 kDa complex is composed of TIM8 (TIMM8A/DDP1 or TIMM8B/DDP2) and TIMM13. Interacts directly with TIMM9, TIMM10/TIM10A and FXC1/TIM10B. {ECO:0000269|PubMed	14726512}. 
# UCSC	uc002fsc	human
# eggNOG	COG5596	LUCA
# eggNOG	KOG3225	Eukaryota
BLAST	swissprot:TIM22_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TIM22_HUMAN
BioCyc	ZFISH:ENSG00000177370-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000177370-MONOMER
COXPRESdb	29928	http://coxpresdb.jp/data/gene/29928.shtml
CleanEx	HS_TIMM22	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TIMM22
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/S0014-5793(99)01665-8	http://dx.doi.org/10.1016/S0014-5793(99)01665-8
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M312485200	http://dx.doi.org/10.1074/jbc.M312485200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF155330	http://www.ebi.ac.uk/ena/data/view/AF155330
EMBL	AK000830	http://www.ebi.ac.uk/ena/data/view/AK000830
EMBL	BC002324	http://www.ebi.ac.uk/ena/data/view/BC002324
Ensembl	ENST00000327158	http://www.ensembl.org/id/ENST00000327158
Ensembl	ENST00000613269	http://www.ensembl.org/id/ENST00000613269
Ensembl	ENST00000617832	http://www.ensembl.org/id/ENST00000617832
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0042721	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042721
GO_function	GO:0015266	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015266
GO_function	GO:0030943	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030943
GO_process	GO:0006626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006626
GO_process	GO:0045039	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045039
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605
GOslim_process	GO:0007005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007005
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
GeneCards	TIMM22	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TIMM22
GeneID	29928	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29928
GeneTree	ENSGT00390000016067	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000016067
HGNC	HGNC:17317	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17317
HOGENOM	HOG000161169	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000161169&db=HOGENOM6
HOVERGEN	HBG054910	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054910&db=HOVERGEN
HPA	HPA045138	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA045138
InParanoid	Q9Y584	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y584
IntAct	Q9Y584	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9Y584*
InterPro	IPR003397	http://www.ebi.ac.uk/interpro/entry/IPR003397
Jabion	29928	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=29928
KEGG_Gene	hsa:29928	http://www.genome.jp/dbget-bin/www_bget?hsa:29928
MIM	607251	http://www.ncbi.nlm.nih.gov/omim/607251
OMA	TTHSYAK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TTHSYAK
OrthoDB	EOG091G0SGH	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0SGH
PSORT	swissprot:TIM22_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TIM22_HUMAN
PSORT-B	swissprot:TIM22_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TIM22_HUMAN
PSORT2	swissprot:TIM22_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TIM22_HUMAN
Pfam	PF02466	http://pfam.xfam.org/family/PF02466
PharmGKB	PA38230	http://www.pharmgkb.org/do/serve?objId=PA38230&objCls=Gene
Phobius	swissprot:TIM22_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TIM22_HUMAN
PhylomeDB	Q9Y584	http://phylomedb.org/?seqid=Q9Y584
ProteinModelPortal	Q9Y584	http://www.proteinmodelportal.org/query/uniprot/Q9Y584
PubMed	10611480	http://www.ncbi.nlm.nih.gov/pubmed/10611480
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	14726512	http://www.ncbi.nlm.nih.gov/pubmed/14726512
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-1268020	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1268020
RefSeq	NP_037469	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_037469
STRING	9606.ENSP00000320236	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000320236&targetmode=cogs
UCSC	uc002fsc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002fsc&org=rat
UniGene	Hs.745034	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.745034
UniProtKB	TIM22_HUMAN	http://www.uniprot.org/uniprot/TIM22_HUMAN
UniProtKB-AC	Q9Y584	http://www.uniprot.org/uniprot/Q9Y584
charge	swissprot:TIM22_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TIM22_HUMAN
eggNOG	COG5596	http://eggnogapi.embl.de/nog_data/html/tree/COG5596
eggNOG	KOG3225	http://eggnogapi.embl.de/nog_data/html/tree/KOG3225
epestfind	swissprot:TIM22_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TIM22_HUMAN
garnier	swissprot:TIM22_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TIM22_HUMAN
helixturnhelix	swissprot:TIM22_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TIM22_HUMAN
hmoment	swissprot:TIM22_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TIM22_HUMAN
iep	swissprot:TIM22_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TIM22_HUMAN
inforesidue	swissprot:TIM22_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TIM22_HUMAN
neXtProt	NX_Q9Y584	http://www.nextprot.org/db/entry/NX_Q9Y584
octanol	swissprot:TIM22_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TIM22_HUMAN
pepcoil	swissprot:TIM22_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TIM22_HUMAN
pepdigest	swissprot:TIM22_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TIM22_HUMAN
pepinfo	swissprot:TIM22_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TIM22_HUMAN
pepnet	swissprot:TIM22_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TIM22_HUMAN
pepstats	swissprot:TIM22_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TIM22_HUMAN
pepwheel	swissprot:TIM22_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TIM22_HUMAN
pepwindow	swissprot:TIM22_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TIM22_HUMAN
sigcleave	swissprot:TIM22_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TIM22_HUMAN
## Database	ID	URL or Descriptions
# AltName	CCG2_HUMAN	Neuronal voltage-gated calcium channel gamma-2 subunit
# AltName	CCG2_HUMAN	Transmembrane AMPAR regulatory protein gamma-2
# BioGrid	115648	20
# DISEASE	CCG2_HUMAN	Mental retardation, autosomal dominant 10 (MRD10) [MIM 614256]  A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO 0000269|PubMed 21376300}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00898	Ethanol
# Ensembl	ENST00000300105	ENSP00000300105; ENSG00000166862
# FUNCTION	CCG2_HUMAN	Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. {ECO 0000269|PubMed 20805473}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005891	voltage-gated calcium channel complex; TAS:ProtInc.
# GO_component	GO:0030666	endocytic vesicle membrane; TAS:Reactome.
# GO_component	GO:0032281	AMPA glutamate receptor complex; ISS:UniProtKB.
# GO_function	GO:0005245	voltage-gated calcium channel activity; TAS:ProtInc.
# GO_function	GO:0005262	calcium channel activity; TAS:Reactome.
# GO_function	GO:0016247	channel regulator activity; IBA:GO_Central.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007528	neuromuscular junction development; IEA:Ensembl.
# GO_process	GO:0019226	transmission of nerve impulse; IBA:GO_Central.
# GO_process	GO:0051899	membrane depolarization; TAS:Reactome.
# GO_process	GO:0060081	membrane hyperpolarization; IEA:Ensembl.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# Genevisible	Q9Y698	HS
# HGNC	HGNC:1406	CACNG2
# InterPro	IPR004031	PMP22/EMP/MP20/Claudin
# InterPro	IPR005422	VDCC_g2su
# InterPro	IPR008368	VDCC_gsu
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00773	[Congenital disorder; Mental retardation] Autosomal dominant mental retardation
# KEGG_Pathway	ko04010	MAPK signaling pathway
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05410	Hypertrophic cardiomyopathy (HCM)
# KEGG_Pathway	ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
# KEGG_Pathway	ko05414	Dilated cardiomyopathy
# MIM	602911	gene
# MIM	614256	phenotype
# Organism	CCG2_HUMAN	Homo sapiens (Human)
# Orphanet	178469	Autosomal dominant non-syndromic intellectual disability
# PRINTS	PR01602	VDCCGAMMA2
# PRINTS	PR01792	VDCCGAMMA
# PTM	CCG2_HUMAN	Phosphorylation of Thr-321 impairs interaction with DLG1 and DLG4. 
# Pfam	PF00822	PMP22_Claudin
# Proteomes	UP000005640	Chromosome 22
# Reactome	R-HSA-112308	Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
# Reactome	R-HSA-399719	Trafficking of AMPA receptors
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# Reactome	R-HSA-5576893	Phase 2 - plateau phase
# Reactome	R-HSA-5576894	Phase 1 - inactivation of fast Na+ channels
# Reactome	R-HSA-5682910	LGI-ADAM interactions
# RecName	CCG2_HUMAN	Voltage-dependent calcium channel gamma-2 subunit
# RefSeq	NP_006069	NM_006078.3
# SIMILARITY	Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	CCG2_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	CCG2_HUMAN	The L-type calcium channel is composed of five subunits  alpha-1, alpha-2/delta, beta and gamma. Interacts with the PDZ domains of DLG4/PSD-95 and DLG1/SAP97. May interact with GOPC (By similarity). Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8 (By similarity). Interacts with GRIA1. {ECO 0000250, ECO 0000269|PubMed 20805473}. 
# TCDB	8.A.16.2	the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family
# TISSUE SPECIFICITY	CCG2_HUMAN	Brain. 
# UCSC	uc003aps	human
# eggNOG	ENOG410IFNQ	Eukaryota
# eggNOG	ENOG4110ISU	LUCA
BLAST	swissprot:CCG2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CCG2_HUMAN
BioCyc	ZFISH:ENSG00000166862-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000166862-MONOMER
COXPRESdb	10369	http://coxpresdb.jp/data/gene/10369.shtml
CleanEx	HS_CACNG2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CACNG2
DIP	DIP-48977N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48977N
DOI	10.1016/j.ajhg.2011.02.001	http://dx.doi.org/10.1016/j.ajhg.2011.02.001
DOI	10.1038/990031	http://dx.doi.org/10.1038/990031
DOI	10.1073/pnas.1011706107	http://dx.doi.org/10.1073/pnas.1011706107
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/gb-2004-5-10-r84	http://dx.doi.org/10.1186/gb-2004-5-10-r84
DOI	10.4065/74.4.357	http://dx.doi.org/10.4065/74.4.357
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
EMBL	AF096322	http://www.ebi.ac.uk/ena/data/view/AF096322
EMBL	AL022313	http://www.ebi.ac.uk/ena/data/view/AL022313
EMBL	AL022313	http://www.ebi.ac.uk/ena/data/view/AL022313
EMBL	AL031845	http://www.ebi.ac.uk/ena/data/view/AL031845
EMBL	AL031845	http://www.ebi.ac.uk/ena/data/view/AL031845
EMBL	AL049749	http://www.ebi.ac.uk/ena/data/view/AL049749
EMBL	AL049749	http://www.ebi.ac.uk/ena/data/view/AL049749
EMBL	BC069612	http://www.ebi.ac.uk/ena/data/view/BC069612
EMBL	BC112297	http://www.ebi.ac.uk/ena/data/view/BC112297
EMBL	BC112299	http://www.ebi.ac.uk/ena/data/view/BC112299
EMBL	CR456414	http://www.ebi.ac.uk/ena/data/view/CR456414
Ensembl	ENST00000300105	http://www.ensembl.org/id/ENST00000300105
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005891
GO_component	GO:0030666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030666
GO_component	GO:0032281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032281
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0016247	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016247
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007528	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007528
GO_process	GO:0019226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019226
GO_process	GO:0051899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051899
GO_process	GO:0060081	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060081
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:2000311	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000311
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	CACNG2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CACNG2
GeneID	10369	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10369
GeneTree	ENSGT00550000074547	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074547
HGNC	HGNC:1406	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1406
HOGENOM	HOG000233440	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233440&db=HOGENOM6
HOVERGEN	HBG003682	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003682&db=HOVERGEN
InParanoid	Q9Y698	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y698
IntAct	Q9Y698	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9Y698*
InterPro	IPR004031	http://www.ebi.ac.uk/interpro/entry/IPR004031
InterPro	IPR005422	http://www.ebi.ac.uk/interpro/entry/IPR005422
InterPro	IPR008368	http://www.ebi.ac.uk/interpro/entry/IPR008368
Jabion	10369	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10369
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00773	http://www.genome.jp/dbget-bin/www_bget?H00773
KEGG_Gene	hsa:10369	http://www.genome.jp/dbget-bin/www_bget?hsa:10369
KEGG_Orthology	KO:K04867	http://www.genome.jp/dbget-bin/www_bget?KO:K04867
KEGG_Pathway	ko04010	http://www.genome.jp/kegg-bin/show_pathway?ko04010
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05410	http://www.genome.jp/kegg-bin/show_pathway?ko05410
KEGG_Pathway	ko05412	http://www.genome.jp/kegg-bin/show_pathway?ko05412
KEGG_Pathway	ko05414	http://www.genome.jp/kegg-bin/show_pathway?ko05414
MIM	602911	http://www.ncbi.nlm.nih.gov/omim/602911
MIM	614256	http://www.ncbi.nlm.nih.gov/omim/614256
OMA	NARATDY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NARATDY
Orphanet	178469	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=178469
OrthoDB	EOG091G0D2Z	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0D2Z
PRINTS	PR01602	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01602
PRINTS	PR01792	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01792
PSORT	swissprot:CCG2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CCG2_HUMAN
PSORT-B	swissprot:CCG2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CCG2_HUMAN
PSORT2	swissprot:CCG2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CCG2_HUMAN
Pfam	PF00822	http://pfam.xfam.org/family/PF00822
PharmGKB	PA26016	http://www.pharmgkb.org/do/serve?objId=PA26016&objCls=Gene
Phobius	swissprot:CCG2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CCG2_HUMAN
PhylomeDB	Q9Y698	http://phylomedb.org/?seqid=Q9Y698
ProteinModelPortal	Q9Y698	http://www.proteinmodelportal.org/query/uniprot/Q9Y698
PubMed	10221464	http://www.ncbi.nlm.nih.gov/pubmed/10221464
PubMed	10591208	http://www.ncbi.nlm.nih.gov/pubmed/10591208
PubMed	15461802	http://www.ncbi.nlm.nih.gov/pubmed/15461802
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	20805473	http://www.ncbi.nlm.nih.gov/pubmed/20805473
PubMed	21376300	http://www.ncbi.nlm.nih.gov/pubmed/21376300
Reactome	R-HSA-112308	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112308
Reactome	R-HSA-399719	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-399719
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
Reactome	R-HSA-5576893	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576893
Reactome	R-HSA-5576894	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576894
Reactome	R-HSA-5682910	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5682910
RefSeq	NP_006069	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006069
STRING	9606.ENSP00000300105	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000300105&targetmode=cogs
TCDB	8.A.16.2	http://www.tcdb.org/search/result.php?tc=8.A.16.2
UCSC	uc003aps	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003aps&org=rat
UniGene	Hs.146766	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.146766
UniProtKB	CCG2_HUMAN	http://www.uniprot.org/uniprot/CCG2_HUMAN
UniProtKB-AC	Q9Y698	http://www.uniprot.org/uniprot/Q9Y698
charge	swissprot:CCG2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CCG2_HUMAN
eggNOG	ENOG410IFNQ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IFNQ
eggNOG	ENOG4110ISU	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110ISU
epestfind	swissprot:CCG2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CCG2_HUMAN
garnier	swissprot:CCG2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CCG2_HUMAN
helixturnhelix	swissprot:CCG2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CCG2_HUMAN
hmoment	swissprot:CCG2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CCG2_HUMAN
iep	swissprot:CCG2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CCG2_HUMAN
inforesidue	swissprot:CCG2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CCG2_HUMAN
neXtProt	NX_Q9Y698	http://www.nextprot.org/db/entry/NX_Q9Y698
octanol	swissprot:CCG2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CCG2_HUMAN
pepcoil	swissprot:CCG2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CCG2_HUMAN
pepdigest	swissprot:CCG2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CCG2_HUMAN
pepinfo	swissprot:CCG2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CCG2_HUMAN
pepnet	swissprot:CCG2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CCG2_HUMAN
pepstats	swissprot:CCG2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CCG2_HUMAN
pepwheel	swissprot:CCG2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CCG2_HUMAN
pepwindow	swissprot:CCG2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CCG2_HUMAN
sigcleave	swissprot:CCG2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CCG2_HUMAN
## Database	ID	URL or Descriptions
# AltName	SC5A3_HUMAN	Sodium/myo-inositol transporter 1
# AltName	SC5A3_HUMAN	Solute carrier family 5 member 3
# ChiTaRS	SLC5A3	human
# Ensembl	ENST00000381151	ENSP00000370543; ENSG00000198743
# FUNCTION	SC5A3_HUMAN	Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_function	SC5A3_HUMAN	GO 0005367 myo-inositol sodium symporter activity; TAS Reactome.
# GO_process	GO:0006020	inositol metabolic process; IBA:GO_Central.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007422	peripheral nervous system development; IEA:Ensembl.
# GO_process	GO:0043576	regulation of respiratory gaseous exchange; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0005975	carbohydrate metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0048856	anatomical structure development
# Genevisible	P53794	HS
# HGNC	HGNC:11038	SLC5A3
# IntAct	P53794	4
# InterPro	IPR001734	Na/solute_symporter
# InterPro	IPR018212	Na/solute_symporter_CS
# MIM	600444	gene
# Organism	SC5A3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11819	PTHR11819
# PIR	A56851	A56851
# PROSITE	PS00456	NA_SOLUT_SYMP_1
# PROSITE	PS00457	NA_SOLUT_SYMP_2
# PROSITE	PS50283	NA_SOLUT_SYMP_3
# Pfam	PF00474	SSF
# Proteomes	UP000005640	Chromosome 21
# Reactome	R-HSA-189200	Hexose transport
# Reactome	R-HSA-428808	Na+-dependent glucose transporters
# Reactome	R-HSA-429593	Inositol transporters
# RecName	SC5A3_HUMAN	Sodium/myo-inositol cotransporter
# SIMILARITY	Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	SC5A3_HUMAN	Membrane; Multi-pass membrane protein. 
# TCDB	2.A.21.3.14:the solute	sodium symporter (sss) family
# TIGRFAMs	TIGR00813	sss
# UCSC	uc002yto	human
# eggNOG	COG4146	LUCA
# eggNOG	ENOG410IP49	Eukaryota
BLAST	swissprot:SC5A3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SC5A3_HUMAN
BioCyc	ZFISH:G66-33037-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33037-MONOMER
DOI	10.1006/geno.1997.5055	http://dx.doi.org/10.1006/geno.1997.5055
DOI	10.1016/0888-7543(95)80052-N	http://dx.doi.org/10.1016/0888-7543(95)80052-N
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/35012518	http://dx.doi.org/10.1038/35012518
EMBL	AF027153	http://www.ebi.ac.uk/ena/data/view/AF027153
EMBL	AP001719	http://www.ebi.ac.uk/ena/data/view/AP001719
EMBL	L38500	http://www.ebi.ac.uk/ena/data/view/L38500
Ensembl	ENST00000381151	http://www.ensembl.org/id/ENST00000381151
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005367	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005367
GO_process	GO:0006020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006020
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007422	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007422
GO_process	GO:0043576	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043576
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GeneCards	SLC5A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC5A3
HGNC	HGNC:11038	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11038
HOGENOM	HOG000025422	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000025422&db=HOGENOM6
HOVERGEN	HBG052859	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052859&db=HOVERGEN
HPA	HPA029791	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA029791
InParanoid	P53794	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P53794
IntAct	P53794	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P53794*
InterPro	IPR001734	http://www.ebi.ac.uk/interpro/entry/IPR001734
InterPro	IPR018212	http://www.ebi.ac.uk/interpro/entry/IPR018212
MIM	600444	http://www.ncbi.nlm.nih.gov/omim/600444
MINT	MINT-4657416	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4657416
OrthoDB	EOG091G077U	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G077U
PANTHER	PTHR11819	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11819
PROSITE	PS00456	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00456
PROSITE	PS00457	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00457
PROSITE	PS50283	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50283
PSORT	swissprot:SC5A3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SC5A3_HUMAN
PSORT-B	swissprot:SC5A3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SC5A3_HUMAN
PSORT2	swissprot:SC5A3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SC5A3_HUMAN
Pfam	PF00474	http://pfam.xfam.org/family/PF00474
PharmGKB	PA35903	http://www.pharmgkb.org/do/serve?objId=PA35903&objCls=Gene
Phobius	swissprot:SC5A3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SC5A3_HUMAN
PhylomeDB	P53794	http://phylomedb.org/?seqid=P53794
ProteinModelPortal	P53794	http://www.proteinmodelportal.org/query/uniprot/P53794
PubMed	10830953	http://www.ncbi.nlm.nih.gov/pubmed/10830953
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	7789985	http://www.ncbi.nlm.nih.gov/pubmed/7789985
PubMed	9441750	http://www.ncbi.nlm.nih.gov/pubmed/9441750
Reactome	R-HSA-189200	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-189200
Reactome	R-HSA-428808	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428808
Reactome	R-HSA-429593	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-429593
STRING	9606.ENSP00000370543	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000370543&targetmode=cogs
TCDB	2.A.21.3.14	http://www.tcdb.org/search/result.php?tc=2.A.21.3.14
TIGRFAMs	TIGR00813	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00813
UCSC	uc002yto	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002yto&org=rat
UniGene	Hs.302742	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.302742
UniProtKB	SC5A3_HUMAN	http://www.uniprot.org/uniprot/SC5A3_HUMAN
UniProtKB-AC	P53794	http://www.uniprot.org/uniprot/P53794
charge	swissprot:SC5A3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SC5A3_HUMAN
eggNOG	COG4146	http://eggnogapi.embl.de/nog_data/html/tree/COG4146
eggNOG	ENOG410IP49	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IP49
epestfind	swissprot:SC5A3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SC5A3_HUMAN
garnier	swissprot:SC5A3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SC5A3_HUMAN
helixturnhelix	swissprot:SC5A3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SC5A3_HUMAN
hmoment	swissprot:SC5A3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SC5A3_HUMAN
iep	swissprot:SC5A3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SC5A3_HUMAN
inforesidue	swissprot:SC5A3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SC5A3_HUMAN
neXtProt	NX_P53794	http://www.nextprot.org/db/entry/NX_P53794
octanol	swissprot:SC5A3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SC5A3_HUMAN
pepcoil	swissprot:SC5A3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SC5A3_HUMAN
pepdigest	swissprot:SC5A3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SC5A3_HUMAN
pepinfo	swissprot:SC5A3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SC5A3_HUMAN
pepnet	swissprot:SC5A3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SC5A3_HUMAN
pepstats	swissprot:SC5A3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SC5A3_HUMAN
pepwheel	swissprot:SC5A3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SC5A3_HUMAN
pepwindow	swissprot:SC5A3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SC5A3_HUMAN
sigcleave	swissprot:SC5A3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SC5A3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ANO9_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A1A5B4-1; Sequence=Displayed; Name=2; IsoId=A1A5B4-2; Sequence=VSP_036489, VSP_036492; Name=3; IsoId=A1A5B4-3; Sequence=VSP_036490, VSP_036491; 
# AltName	ANO9_HUMAN	Transmembrane protein 16J
# AltName	ANO9_HUMAN	Tumor protein p53-inducible protein 5
# AltName	ANO9_HUMAN	p53-induced gene 5 protein
# CCDS	CCDS31326	-. [A1A5B4-1]
# ChiTaRS	ANO9	human
# Ensembl	ENST00000332826	ENSP00000332788; ENSG00000185101. [A1A5B4-1]
# FUNCTION	ANO9_HUMAN	Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium- activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1. {ECO 0000250|UniProtKB P86044, ECO 0000269|PubMed 20056604, ECO 0000269|PubMed 22946059}. 
# GO_component	GO:0005622	intracellular; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005229	intracellular calcium activated chloride channel activity; IMP:UniProtKB.
# GO_function	GO:0017128	phospholipid scramblase activity; IEA:Ensembl.
# GO_process	GO:0006821	chloride transport; IMP:UniProtKB.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0061589	calcium activated phosphatidylserine scrambling; IEA:Ensembl.
# GO_process	GO:0061590	calcium activated phosphatidylcholine scrambling; IEA:Ensembl.
# GO_process	GO:0061591	calcium activated galactosylceramide scrambling; IEA:Ensembl.
# GO_process	GO:1902939	negative regulation of intracellular calcium activated chloride channel activity; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005622	intracellular
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007009	plasma membrane organization
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	A1A5B4	HS
# HGNC	HGNC:20679	ANO9
# InterPro	IPR007632	Anoctamin
# InterPro	IPR031290	Anoctamin-9
# MISCELLANEOUS	ANO9_HUMAN	The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology. 
# Organism	ANO9_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12308	PTHR12308
# PANTHER	PTHR12308:SF37	PTHR12308:SF37
# Pfam	PF04547	Anoctamin
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	ANO9_HUMAN	Anoctamin-9
# RefSeq	NP_001012302	NM_001012302.2. [A1A5B4-1]
# RefSeq	XP_011518355	XM_011520053.2. [A1A5B4-2]
# SEQUENCE CAUTION	Sequence=BAB84914.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the anoctamin family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	ANO9_HUMAN	Cell membrane {ECO 0000269|PubMed 20056604, ECO 0000269|PubMed 22946059}; Multi-pass membrane protein {ECO 0000269|PubMed 20056604, ECO 0000269|PubMed 22946059}. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane. 
# TCDB	1.A.17.1	the calcium-dependent chloride channel (ca-clc) family
# UCSC	uc001lpi	human. [A1A5B4-1]
# eggNOG	ENOG410XS4S	LUCA
# eggNOG	KOG2514	Eukaryota
BLAST	swissprot:ANO9_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ANO9_HUMAN
COXPRESdb	338440	http://coxpresdb.jp/data/gene/338440.shtml
CleanEx	HS_ANO9	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ANO9
DOI	10.1007/s00424-011-0975-9	http://dx.doi.org/10.1007/s00424-011-0975-9
DOI	10.1038/aps.2011.48	http://dx.doi.org/10.1038/aps.2011.48
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M109.065367	http://dx.doi.org/10.1074/jbc.M109.065367
DOI	10.1093/dnares/10.1.49	http://dx.doi.org/10.1093/dnares/10.1.49
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1113/expphysiol.2011.058198	http://dx.doi.org/10.1113/expphysiol.2011.058198
DOI	10.1113/expphysiol.2011.058214	http://dx.doi.org/10.1113/expphysiol.2011.058214
DOI	10.1159/000335765	http://dx.doi.org/10.1159/000335765
DOI	10.1242/jcs.109553	http://dx.doi.org/10.1242/jcs.109553
EMBL	AC138230	http://www.ebi.ac.uk/ena/data/view/AC138230
EMBL	AK074088	http://www.ebi.ac.uk/ena/data/view/AK074088
EMBL	AK096874	http://www.ebi.ac.uk/ena/data/view/AK096874
EMBL	AK303642	http://www.ebi.ac.uk/ena/data/view/AK303642
EMBL	BC128557	http://www.ebi.ac.uk/ena/data/view/BC128557
Ensembl	ENST00000332826	http://www.ensembl.org/id/ENST00000332826
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005229	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005229
GO_function	GO:0017128	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017128
GO_process	GO:0006821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006821
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0061589	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061589
GO_process	GO:0061590	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061590
GO_process	GO:0061591	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061591
GO_process	GO:1902939	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902939
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007009
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ANO9	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ANO9
GeneID	338440	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=338440
GeneTree	ENSGT00760000119015	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119015
HGNC	HGNC:20679	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20679
HOGENOM	HOG000006509	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006509&db=HOGENOM6
HOVERGEN	HBG100444	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG100444&db=HOVERGEN
HPA	HPA039948	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA039948
InParanoid	A1A5B4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=A1A5B4
IntAct	A1A5B4	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=A1A5B4*
InterPro	IPR007632	http://www.ebi.ac.uk/interpro/entry/IPR007632
InterPro	IPR031290	http://www.ebi.ac.uk/interpro/entry/IPR031290
Jabion	338440	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=338440
KEGG_Gene	hsa:338440	http://www.genome.jp/dbget-bin/www_bget?hsa:338440
OMA	KYHYGPC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KYHYGPC
OrthoDB	EOG091G02JM	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02JM
PANTHER	PTHR12308	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12308
PANTHER	PTHR12308:SF37	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12308:SF37
PSORT	swissprot:ANO9_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ANO9_HUMAN
PSORT-B	swissprot:ANO9_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ANO9_HUMAN
PSORT2	swissprot:ANO9_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ANO9_HUMAN
Pfam	PF04547	http://pfam.xfam.org/family/PF04547
PharmGKB	PA164715791	http://www.pharmgkb.org/do/serve?objId=PA164715791&objCls=Gene
Phobius	swissprot:ANO9_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ANO9_HUMAN
ProteinModelPortal	A1A5B4	http://www.proteinmodelportal.org/query/uniprot/A1A5B4
PubMed	12693554	http://www.ncbi.nlm.nih.gov/pubmed/12693554
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	20056604	http://www.ncbi.nlm.nih.gov/pubmed/20056604
PubMed	21607626	http://www.ncbi.nlm.nih.gov/pubmed/21607626
PubMed	21642943	http://www.ncbi.nlm.nih.gov/pubmed/21642943
PubMed	21984732	http://www.ncbi.nlm.nih.gov/pubmed/21984732
PubMed	22178883	http://www.ncbi.nlm.nih.gov/pubmed/22178883
PubMed	22302790	http://www.ncbi.nlm.nih.gov/pubmed/22302790
PubMed	22946059	http://www.ncbi.nlm.nih.gov/pubmed/22946059
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_001012302	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001012302
RefSeq	XP_011518355	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011518355
STRING	9606.ENSP00000332788	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000332788&targetmode=cogs
TCDB	1.A.17.1	http://www.tcdb.org/search/result.php?tc=1.A.17.1
UCSC	uc001lpi	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001lpi&org=rat
UniGene	Hs.501622	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.501622
UniProtKB	ANO9_HUMAN	http://www.uniprot.org/uniprot/ANO9_HUMAN
UniProtKB-AC	A1A5B4	http://www.uniprot.org/uniprot/A1A5B4
charge	swissprot:ANO9_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ANO9_HUMAN
eggNOG	ENOG410XS4S	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS4S
eggNOG	KOG2514	http://eggnogapi.embl.de/nog_data/html/tree/KOG2514
epestfind	swissprot:ANO9_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ANO9_HUMAN
garnier	swissprot:ANO9_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ANO9_HUMAN
helixturnhelix	swissprot:ANO9_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ANO9_HUMAN
hmoment	swissprot:ANO9_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ANO9_HUMAN
iep	swissprot:ANO9_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ANO9_HUMAN
inforesidue	swissprot:ANO9_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ANO9_HUMAN
neXtProt	NX_A1A5B4	http://www.nextprot.org/db/entry/NX_A1A5B4
octanol	swissprot:ANO9_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ANO9_HUMAN
pepcoil	swissprot:ANO9_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ANO9_HUMAN
pepdigest	swissprot:ANO9_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ANO9_HUMAN
pepinfo	swissprot:ANO9_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ANO9_HUMAN
pepnet	swissprot:ANO9_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ANO9_HUMAN
pepstats	swissprot:ANO9_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ANO9_HUMAN
pepwheel	swissprot:ANO9_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ANO9_HUMAN
pepwindow	swissprot:ANO9_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ANO9_HUMAN
sigcleave	swissprot:ANO9_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ANO9_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	MCL1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=MCL1L, MCL-1L; IsoId=Q07820-1; Sequence=Displayed; Name=2; Synonyms=Delta S, MCL-1S, TM; IsoId=Q07820-2; Sequence=VSP_000532, VSP_000533; 
# AltName	MCL1_HUMAN	Bcl-2-like protein 3
# AltName	MCL1_HUMAN	Bcl-2-related protein EAT/mcl1
# AltName	MCL1_HUMAN	mcl1/EAT
# BioGrid	110338	63
# CCDS	CCDS956	-. [Q07820-2]
# CCDS	CCDS957	-. [Q07820-1]
# ChiTaRS	MCL1	human
# Ensembl	ENST00000307940	ENSP00000309973; ENSG00000143384. [Q07820-2]
# Ensembl	ENST00000369026	ENSP00000358022; ENSG00000143384. [Q07820-1]
# ExpressionAtlas	Q07820	baseline and differential
# FUNCTION	MCL1_HUMAN	Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. {ECO 0000269|PubMed 10766760, ECO 0000269|PubMed 16543145}. 
# GO_component	GO:0005634	nucleus; IDA:MGI.
# GO_component	GO:0005654	nucleoplasm; IEA:UniProtKB-SubCell.
# GO_component	GO:0005737	cytoplasm; TAS:UniProtKB.
# GO_component	GO:0005739	mitochondrion; IDA:MGI.
# GO_component	GO:0005741	mitochondrial outer membrane; TAS:UniProtKB.
# GO_component	GO:0005759	mitochondrial matrix; IEA:Ensembl.
# GO_component	GO:0005829	cytosol; ISS:UniProtKB.
# GO_component	GO:0016020	membrane; ISS:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0097136	Bcl-2 family protein complex; IDA:UniProtKB.
# GO_function	GO:0015266	protein channel activity; TAS:UniProtKB.
# GO_function	GO:0042803	protein homodimerization activity; IBA:GO_Central.
# GO_function	GO:0046982	protein heterodimerization activity; IPI:UniProtKB.
# GO_function	GO:0051434	BH3 domain binding; IPI:BHF-UCL.
# GO_process	GO:0001709	cell fate determination; NAS:UniProtKB.
# GO_process	GO:0007275	multicellular organism development; IEA:UniProtKB-KW.
# GO_process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage; IBA:GO_Central.
# GO_process	GO:0008637	apoptotic mitochondrial changes; IEA:Ensembl.
# GO_process	GO:0010507	negative regulation of autophagy; IMP:UniProtKB.
# GO_process	GO:0019725	cellular homeostasis; NAS:UniProtKB.
# GO_process	GO:0034097	response to cytokine; IDA:MGI.
# GO_process	GO:0043066	negative regulation of apoptotic process; IDA:BHF-UCL.
# GO_process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand; IMP:UniProtKB.
# GO_process	GO:1903378	positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; IGI:ParkinsonsUK-UCL.
# GO_process	GO:2000811	negative regulation of anoikis; IMP:UniProtKB.
# GO_process	GO:2001020	regulation of response to DNA damage stimulus; IMP:MGI.
# GO_process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IMP:UniProtKB.
# GO_process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007005	mitochondrion organization
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# Genevisible	Q07820	HS
# HGNC	HGNC:6943	MCL1
# INDUCTION	MCL1_HUMAN	Expression increases early during phorbol ester-induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell line ML-1. Rapidly up-regulated by CSF2 in ML-1 cells. Up-regulated by heat shock-induced differentiation. Expression increases early during retinoic acid-induced differentiation. {ECO 0000269|PubMed 8790944, ECO 0000269|PubMed 9671497}. 
# INTERACTION	MCL1_HUMAN	Q91AU0 - (xeno); NbExp=2; IntAct=EBI-1003422, EBI-9657017; Q16611 BAK1; NbExp=12; IntAct=EBI-1003422, EBI-519866; Q07812 BAX; NbExp=6; IntAct=EBI-1003422, EBI-516580; Q9BXH1 BBC3; NbExp=3; IntAct=EBI-1003422, EBI-519884; O43521 BCL2L11; NbExp=15; IntAct=EBI-1003422, EBI-526406; Q14457 BECN1; NbExp=2; IntAct=EBI-1003422, EBI-949378; Q7L3V2 BOP; NbExp=2; IntAct=EBI-1003422, EBI-10697720; Q03135 CAV1; NbExp=3; IntAct=EBI-1003422, EBI-603614; P49817 Cav1 (xeno); NbExp=3; IntAct=EBI-1003422, EBI-1161338; Q13794 PMAIP1; NbExp=5; IntAct=EBI-1003422, EBI-707392; Q9JM54 Pmaip1 (xeno); NbExp=2; IntAct=EBI-1003422, EBI-709183; 
# IntAct	Q07820	28
# InterPro	IPR002475	Bcl2-like
# InterPro	IPR013281	Apop_reg_Mc1
# InterPro	IPR020717	Bcl2_BH1_motif_CS
# InterPro	IPR020726	Bcl2_BH2_motif_CS
# InterPro	IPR020728	Bcl2_BH3_motif_CS
# InterPro	IPR026298	Blc2_fam
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Pathway	ko04151	PI3K-Akt signaling pathway
# MIM	159552	gene
# Organism	MCL1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11256	PTHR11256
# PDB	2KBW	NMR; -; A=163-326
# PDB	2MHS	NMR; -; A=171-327
# PDB	2NL9	X-ray; 1.55 A; A=209-327
# PDB	2NLA	X-ray; 2.80 A; A=209-327
# PDB	2PQK	X-ray; 2.00 A; A=172-327
# PDB	3D7V	X-ray; 2.03 A; A=209-327
# PDB	3IO9	X-ray; 2.40 A; A=209-327
# PDB	3KJ0	X-ray; 1.70 A; A=172-327
# PDB	3KJ1	X-ray; 1.94 A; A=172-327
# PDB	3KJ2	X-ray; 2.35 A; A=172-327
# PDB	3KZ0	X-ray; 2.35 A; A/B=172-327
# PDB	3MK8	X-ray; 2.32 A; A=172-327, B=208-228
# PDB	3PK1	X-ray; 2.49 A; A/C=174-326
# PDB	3TWU	X-ray; 1.80 A; B=73-88
# PDB	3WIX	X-ray; 1.90 A; A/B/C/D=172-327
# PDB	3WIY	X-ray; 2.15 A; A/B/C/D/E/F=172-327
# PDB	4BPI	X-ray; 1.98 A; A=209-327
# PDB	4BPJ	X-ray; 1.60 A; A=209-327
# PDB	4HW2	X-ray; 2.80 A; A/B/C/D/E/F=172-323
# PDB	4HW3	X-ray; 2.40 A; A/B/C/D/E/F/G/H/I/J/K/L=172-323
# PDB	4HW4	X-ray; 1.53 A; A/B=172-327
# PDB	4OQ5	X-ray; 2.86 A; A/B/C/D/E/F=174-326
# PDB	4OQ6	X-ray; 1.81 A; A/B=174-326
# PDB	4WGI	X-ray; 1.85 A; A=173-321
# PDB	4WMR	X-ray; 1.70 A; A=173-321
# PDB	4WMS	X-ray; 1.90 A; A=174-321
# PDB	4WMT	X-ray; 2.35 A; A=174-321
# PDB	4WMU	X-ray; 1.55 A; A=174-321
# PDB	4WMV	X-ray; 2.40 A; A=174-321
# PDB	4WMW	X-ray; 1.90 A; A=174-321
# PDB	4WMX	X-ray; 2.00 A; A=174-321
# PDB	4ZBF	X-ray; 2.20 A; A/B/C/D/E/F/G/H/I/J/K/L=172-327
# PDB	4ZBI	X-ray; 2.50 A; A/B/C/D/E/F/G/H/I/J/K/L=172-327
# PDB	5C3F	X-ray; 1.43 A; A=173-327
# PDB	5C6H	X-ray; 2.05 A; A/C/E/G/I/K/M/O/Q/S/U/W=171-327
# PDB	5FC4	X-ray; 1.50 A; A=172-320
# PDB	5FDO	X-ray; 2.80 A; A/B/C/D=172-320
# PDB	5FDR	X-ray; 2.60 A; A/B/C/D=172-327
# PIR	A47476	A47476
# PRINTS	PR01862	BCL2FAMILY
# PRINTS	PR01866	APOPREGMCL1
# PROSITE	PS01080	BH1
# PROSITE	PS01258	BH2
# PROSITE	PS01259	BH3
# PROSITE	PS50062	BCL2_FAMILY
# PTM	MCL1_HUMAN	Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment. 
# PTM	MCL1_HUMAN	Phosphorylated on Ser-159, by GSK3, in response to IL3/interleukin-3 withdrawal. Phosphorylation at Ser-159 induces ubiquitination and proteasomal degradation, abrogating the anti- apoptotic activity. Treatment with taxol or okadaic acid induces phosphorylation on additional sites. {ECO 0000269|PubMed 16543145}. 
# PTM	MCL1_HUMAN	Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region. {ECO 0000269|PubMed 12223490, ECO 0000269|PubMed 15241487, ECO 0000269|PubMed 23024798}. 
# PTM	MCL1_HUMAN	Ubiquitinated. Ubiquitination is induced by phosphorylation at Ser-159. {ECO 0000269|PubMed 16543145}. 
# Pfam	PF00452	Bcl-2
# Proteomes	UP000005640	Chromosome 1
# RecName	MCL1_HUMAN	Induced myeloid leukemia cell differentiation protein Mcl-1
# RefSeq	NP_001184249	NM_001197320.1
# RefSeq	NP_068779	NM_021960.4. [Q07820-1]
# RefSeq	NP_877495	NM_182763.2. [Q07820-2]
# SIMILARITY	Belongs to the Bcl-2 family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	MCL1_HUMAN	Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria. 
# SUBUNIT	MCL1_HUMAN	Interacts with HIF3A (via C-terminus domain) (By similarity). Interacts with BAD, BOK, BIK and BMF (By similarity). Interacts with PMAIP1 (PubMed 17389404). Interacts with BBC3 (By similarity). Isoform 1 interacts with BAX, BAK1 and TPT1 (PubMed 10837489, PubMed 12149273, PubMed 15077116). Heterodimer of isoform 1 and isoform 2. Homodimers of isoform 1 or isoform 2 are not detected. Isoform 2 does not interact with pro-apoptotic BCL2-related proteins (PubMed 10837489). Interacts with BOP (PubMed 23055042). Interacts with BCL2L11; may sequester BCL2L11 to prevent its pro-apoptotic activity (PubMed 10837489, PubMed 27013495, PubMed 17389404, PubMed 20562877). {ECO 0000250|UniProtKB P97287, ECO 0000250|UniProtKB Q9Z1P3, ECO 0000269|PubMed 10837489, ECO 0000269|PubMed 12149273, ECO 0000269|PubMed 15077116, ECO 0000269|PubMed 17389404, ECO 0000269|PubMed 20562877, ECO 0000269|PubMed 23055042, ECO 0000269|PubMed 27013495}. 
# UCSC	uc001euz	human. [Q07820-1]
# WEB RESOURCE	MCL1_HUMAN	Name=NIEHS-SNPs; URL="http //egp.gs.washington.edu/data/mcl1/";
# eggNOG	ENOG41123S0	LUCA
# eggNOG	KOG4728	Eukaryota
BLAST	swissprot:MCL1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MCL1_HUMAN
BioCyc	ZFISH:ENSG00000143384-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000143384-MONOMER
COXPRESdb	4170	http://coxpresdb.jp/data/gene/4170.shtml
CleanEx	HS_MCL1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_MCL1
DIP	DIP-231N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-231N
DOI	10.1007/PL00000728	http://dx.doi.org/10.1007/PL00000728
DOI	10.1007/s13238-012-2069-7	http://dx.doi.org/10.1007/s13238-012-2069-7
DOI	10.1016/S0145-2126(99)00137-X	http://dx.doi.org/10.1016/S0145-2126(99)00137-X
DOI	10.1016/j.cell.2005.06.009	http://dx.doi.org/10.1016/j.cell.2005.06.009
DOI	10.1016/j.molcel.2006.02.009	http://dx.doi.org/10.1016/j.molcel.2006.02.009
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/nature07485	http://dx.doi.org/10.1038/nature07485
DOI	10.1038/ncb1123	http://dx.doi.org/10.1038/ncb1123
DOI	10.1038/nchembio.391	http://dx.doi.org/10.1038/nchembio.391
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.onc.1207648	http://dx.doi.org/10.1038/sj.onc.1207648
DOI	10.1038/sj.onc.1207692	http://dx.doi.org/10.1038/sj.onc.1207692
DOI	10.1073/pnas.0701297104	http://dx.doi.org/10.1073/pnas.0701297104
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.90.8.3516	http://dx.doi.org/10.1073/pnas.90.8.3516
DOI	10.1074/jbc.M207413200	http://dx.doi.org/10.1074/jbc.M207413200
DOI	10.1074/jbc.M207951200	http://dx.doi.org/10.1074/jbc.M207951200
DOI	10.1074/jbc.M909572199	http://dx.doi.org/10.1074/jbc.M909572199
DOI	10.1074/jbc.M909826199	http://dx.doi.org/10.1074/jbc.M909826199
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1128/MCB.18.8.4883	http://dx.doi.org/10.1128/MCB.18.8.4883
DOI	10.1371/journal.pone.0045088	http://dx.doi.org/10.1371/journal.pone.0045088
DOI	10.15252/embr.201541392	http://dx.doi.org/10.15252/embr.201541392
EMBL	AF118124	http://www.ebi.ac.uk/ena/data/view/AF118124
EMBL	AF118276	http://www.ebi.ac.uk/ena/data/view/AF118276
EMBL	AF118277	http://www.ebi.ac.uk/ena/data/view/AF118277
EMBL	AF118278	http://www.ebi.ac.uk/ena/data/view/AF118278
EMBL	AF147742	http://www.ebi.ac.uk/ena/data/view/AF147742
EMBL	AF162676	http://www.ebi.ac.uk/ena/data/view/AF162676
EMBL	AF162677	http://www.ebi.ac.uk/ena/data/view/AF162677
EMBL	AF198614	http://www.ebi.ac.uk/ena/data/view/AF198614
EMBL	AF198614	http://www.ebi.ac.uk/ena/data/view/AF198614
EMBL	AF203373	http://www.ebi.ac.uk/ena/data/view/AF203373
EMBL	AK312508	http://www.ebi.ac.uk/ena/data/view/AK312508
EMBL	AL356356	http://www.ebi.ac.uk/ena/data/view/AL356356
EMBL	AL356356	http://www.ebi.ac.uk/ena/data/view/AL356356
EMBL	BC017197	http://www.ebi.ac.uk/ena/data/view/BC017197
EMBL	BC071897	http://www.ebi.ac.uk/ena/data/view/BC071897
EMBL	BC107735	http://www.ebi.ac.uk/ena/data/view/BC107735
EMBL	BT006640	http://www.ebi.ac.uk/ena/data/view/BT006640
EMBL	CH471121	http://www.ebi.ac.uk/ena/data/view/CH471121
EMBL	CH471121	http://www.ebi.ac.uk/ena/data/view/CH471121
EMBL	CH471121	http://www.ebi.ac.uk/ena/data/view/CH471121
EMBL	CH471121	http://www.ebi.ac.uk/ena/data/view/CH471121
EMBL	DQ088966	http://www.ebi.ac.uk/ena/data/view/DQ088966
EMBL	L08246	http://www.ebi.ac.uk/ena/data/view/L08246
Ensembl	ENST00000307940	http://www.ensembl.org/id/ENST00000307940
Ensembl	ENST00000369026	http://www.ensembl.org/id/ENST00000369026
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005741	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005741
GO_component	GO:0005759	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005759
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0097136	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097136
GO_function	GO:0015266	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015266
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_function	GO:0046982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046982
GO_function	GO:0051434	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051434
GO_process	GO:0001709	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001709
GO_process	GO:0007275	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007275
GO_process	GO:0008630	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008630
GO_process	GO:0008637	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008637
GO_process	GO:0010507	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010507
GO_process	GO:0019725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019725
GO_process	GO:0034097	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034097
GO_process	GO:0043066	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043066
GO_process	GO:0097192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097192
GO_process	GO:1903378	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903378
GO_process	GO:2000811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000811
GO_process	GO:2001020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001020
GO_process	GO:2001240	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001240
GO_process	GO:2001243	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001243
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007005
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GeneCards	MCL1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=MCL1
GeneID	4170	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4170
GeneTree	ENSGT00510000048923	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00510000048923
HGNC	HGNC:6943	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6943
HOVERGEN	HBG003527	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003527&db=HOVERGEN
HPA	CAB002781	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB002781
HPA	CAB068195	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB068195
HPA	HPA008455	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA008455
HPA	HPA031125	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031125
InParanoid	Q07820	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q07820
IntAct	Q07820	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q07820*
InterPro	IPR002475	http://www.ebi.ac.uk/interpro/entry/IPR002475
InterPro	IPR013281	http://www.ebi.ac.uk/interpro/entry/IPR013281
InterPro	IPR020717	http://www.ebi.ac.uk/interpro/entry/IPR020717
InterPro	IPR020726	http://www.ebi.ac.uk/interpro/entry/IPR020726
InterPro	IPR020728	http://www.ebi.ac.uk/interpro/entry/IPR020728
InterPro	IPR026298	http://www.ebi.ac.uk/interpro/entry/IPR026298
Jabion	4170	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=4170
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Gene	hsa:4170	http://www.genome.jp/dbget-bin/www_bget?hsa:4170
KEGG_Orthology	KO:K02539	http://www.genome.jp/dbget-bin/www_bget?KO:K02539
KEGG_Pathway	ko04151	http://www.genome.jp/kegg-bin/show_pathway?ko04151
MIM	159552	http://www.ncbi.nlm.nih.gov/omim/159552
MINT	MINT-89669	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-89669
OMA	AKDTKPM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AKDTKPM
OrthoDB	EOG091G0E6Q	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0E6Q
PANTHER	PTHR11256	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11256
PDB	2KBW	http://www.ebi.ac.uk/pdbe-srv/view/entry/2KBW
PDB	2MHS	http://www.ebi.ac.uk/pdbe-srv/view/entry/2MHS
PDB	2NL9	http://www.ebi.ac.uk/pdbe-srv/view/entry/2NL9
PDB	2NLA	http://www.ebi.ac.uk/pdbe-srv/view/entry/2NLA
PDB	2PQK	http://www.ebi.ac.uk/pdbe-srv/view/entry/2PQK
PDB	3D7V	http://www.ebi.ac.uk/pdbe-srv/view/entry/3D7V
PDB	3IO9	http://www.ebi.ac.uk/pdbe-srv/view/entry/3IO9
PDB	3KJ0	http://www.ebi.ac.uk/pdbe-srv/view/entry/3KJ0
PDB	3KJ1	http://www.ebi.ac.uk/pdbe-srv/view/entry/3KJ1
PDB	3KJ2	http://www.ebi.ac.uk/pdbe-srv/view/entry/3KJ2
PDB	3KZ0	http://www.ebi.ac.uk/pdbe-srv/view/entry/3KZ0
PDB	3MK8	http://www.ebi.ac.uk/pdbe-srv/view/entry/3MK8
PDB	3PK1	http://www.ebi.ac.uk/pdbe-srv/view/entry/3PK1
PDB	3TWU	http://www.ebi.ac.uk/pdbe-srv/view/entry/3TWU
PDB	3WIX	http://www.ebi.ac.uk/pdbe-srv/view/entry/3WIX
PDB	3WIY	http://www.ebi.ac.uk/pdbe-srv/view/entry/3WIY
PDB	4BPI	http://www.ebi.ac.uk/pdbe-srv/view/entry/4BPI
PDB	4BPJ	http://www.ebi.ac.uk/pdbe-srv/view/entry/4BPJ
PDB	4HW2	http://www.ebi.ac.uk/pdbe-srv/view/entry/4HW2
PDB	4HW3	http://www.ebi.ac.uk/pdbe-srv/view/entry/4HW3
PDB	4HW4	http://www.ebi.ac.uk/pdbe-srv/view/entry/4HW4
PDB	4OQ5	http://www.ebi.ac.uk/pdbe-srv/view/entry/4OQ5
PDB	4OQ6	http://www.ebi.ac.uk/pdbe-srv/view/entry/4OQ6
PDB	4WGI	http://www.ebi.ac.uk/pdbe-srv/view/entry/4WGI
PDB	4WMR	http://www.ebi.ac.uk/pdbe-srv/view/entry/4WMR
PDB	4WMS	http://www.ebi.ac.uk/pdbe-srv/view/entry/4WMS
PDB	4WMT	http://www.ebi.ac.uk/pdbe-srv/view/entry/4WMT
PDB	4WMU	http://www.ebi.ac.uk/pdbe-srv/view/entry/4WMU
PDB	4WMV	http://www.ebi.ac.uk/pdbe-srv/view/entry/4WMV
PDB	4WMW	http://www.ebi.ac.uk/pdbe-srv/view/entry/4WMW
PDB	4WMX	http://www.ebi.ac.uk/pdbe-srv/view/entry/4WMX
PDB	4ZBF	http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZBF
PDB	4ZBI	http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZBI
PDB	5C3F	http://www.ebi.ac.uk/pdbe-srv/view/entry/5C3F
PDB	5C6H	http://www.ebi.ac.uk/pdbe-srv/view/entry/5C6H
PDB	5FC4	http://www.ebi.ac.uk/pdbe-srv/view/entry/5FC4
PDB	5FDO	http://www.ebi.ac.uk/pdbe-srv/view/entry/5FDO
PDB	5FDR	http://www.ebi.ac.uk/pdbe-srv/view/entry/5FDR
PDBsum	2KBW	http://www.ebi.ac.uk/pdbsum/2KBW
PDBsum	2MHS	http://www.ebi.ac.uk/pdbsum/2MHS
PDBsum	2NL9	http://www.ebi.ac.uk/pdbsum/2NL9
PDBsum	2NLA	http://www.ebi.ac.uk/pdbsum/2NLA
PDBsum	2PQK	http://www.ebi.ac.uk/pdbsum/2PQK
PDBsum	3D7V	http://www.ebi.ac.uk/pdbsum/3D7V
PDBsum	3IO9	http://www.ebi.ac.uk/pdbsum/3IO9
PDBsum	3KJ0	http://www.ebi.ac.uk/pdbsum/3KJ0
PDBsum	3KJ1	http://www.ebi.ac.uk/pdbsum/3KJ1
PDBsum	3KJ2	http://www.ebi.ac.uk/pdbsum/3KJ2
PDBsum	3KZ0	http://www.ebi.ac.uk/pdbsum/3KZ0
PDBsum	3MK8	http://www.ebi.ac.uk/pdbsum/3MK8
PDBsum	3PK1	http://www.ebi.ac.uk/pdbsum/3PK1
PDBsum	3TWU	http://www.ebi.ac.uk/pdbsum/3TWU
PDBsum	3WIX	http://www.ebi.ac.uk/pdbsum/3WIX
PDBsum	3WIY	http://www.ebi.ac.uk/pdbsum/3WIY
PDBsum	4BPI	http://www.ebi.ac.uk/pdbsum/4BPI
PDBsum	4BPJ	http://www.ebi.ac.uk/pdbsum/4BPJ
PDBsum	4HW2	http://www.ebi.ac.uk/pdbsum/4HW2
PDBsum	4HW3	http://www.ebi.ac.uk/pdbsum/4HW3
PDBsum	4HW4	http://www.ebi.ac.uk/pdbsum/4HW4
PDBsum	4OQ5	http://www.ebi.ac.uk/pdbsum/4OQ5
PDBsum	4OQ6	http://www.ebi.ac.uk/pdbsum/4OQ6
PDBsum	4WGI	http://www.ebi.ac.uk/pdbsum/4WGI
PDBsum	4WMR	http://www.ebi.ac.uk/pdbsum/4WMR
PDBsum	4WMS	http://www.ebi.ac.uk/pdbsum/4WMS
PDBsum	4WMT	http://www.ebi.ac.uk/pdbsum/4WMT
PDBsum	4WMU	http://www.ebi.ac.uk/pdbsum/4WMU
PDBsum	4WMV	http://www.ebi.ac.uk/pdbsum/4WMV
PDBsum	4WMW	http://www.ebi.ac.uk/pdbsum/4WMW
PDBsum	4WMX	http://www.ebi.ac.uk/pdbsum/4WMX
PDBsum	4ZBF	http://www.ebi.ac.uk/pdbsum/4ZBF
PDBsum	4ZBI	http://www.ebi.ac.uk/pdbsum/4ZBI
PDBsum	5C3F	http://www.ebi.ac.uk/pdbsum/5C3F
PDBsum	5C6H	http://www.ebi.ac.uk/pdbsum/5C6H
PDBsum	5FC4	http://www.ebi.ac.uk/pdbsum/5FC4
PDBsum	5FDO	http://www.ebi.ac.uk/pdbsum/5FDO
PDBsum	5FDR	http://www.ebi.ac.uk/pdbsum/5FDR
PRINTS	PR01862	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01862
PRINTS	PR01866	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01866
PROSITE	PS01080	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01080
PROSITE	PS01258	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01258
PROSITE	PS01259	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01259
PROSITE	PS50062	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50062
PSORT	swissprot:MCL1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MCL1_HUMAN
PSORT-B	swissprot:MCL1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MCL1_HUMAN
PSORT2	swissprot:MCL1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MCL1_HUMAN
Pfam	PF00452	http://pfam.xfam.org/family/PF00452
PharmGKB	PA30688	http://www.pharmgkb.org/do/serve?objId=PA30688&objCls=Gene
Phobius	swissprot:MCL1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MCL1_HUMAN
PhylomeDB	Q07820	http://phylomedb.org/?seqid=Q07820
ProteinModelPortal	Q07820	http://www.proteinmodelportal.org/query/uniprot/Q07820
PubMed	10634649	http://www.ncbi.nlm.nih.gov/pubmed/10634649
PubMed	10766760	http://www.ncbi.nlm.nih.gov/pubmed/10766760
PubMed	10837489	http://www.ncbi.nlm.nih.gov/pubmed/10837489
PubMed	11130466	http://www.ncbi.nlm.nih.gov/pubmed/11130466
PubMed	12149273	http://www.ncbi.nlm.nih.gov/pubmed/12149273
PubMed	12223490	http://www.ncbi.nlm.nih.gov/pubmed/12223490
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15077116	http://www.ncbi.nlm.nih.gov/pubmed/15077116
PubMed	15122313	http://www.ncbi.nlm.nih.gov/pubmed/15122313
PubMed	15241487	http://www.ncbi.nlm.nih.gov/pubmed/15241487
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15989957	http://www.ncbi.nlm.nih.gov/pubmed/15989957
PubMed	16543145	http://www.ncbi.nlm.nih.gov/pubmed/16543145
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17389404	http://www.ncbi.nlm.nih.gov/pubmed/17389404
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18987736	http://www.ncbi.nlm.nih.gov/pubmed/18987736
PubMed	20562877	http://www.ncbi.nlm.nih.gov/pubmed/20562877
PubMed	23024798	http://www.ncbi.nlm.nih.gov/pubmed/23024798
PubMed	23055042	http://www.ncbi.nlm.nih.gov/pubmed/23055042
PubMed	27013495	http://www.ncbi.nlm.nih.gov/pubmed/27013495
PubMed	7682708	http://www.ncbi.nlm.nih.gov/pubmed/7682708
PubMed	8790944	http://www.ncbi.nlm.nih.gov/pubmed/8790944
PubMed	9671497	http://www.ncbi.nlm.nih.gov/pubmed/9671497
RefSeq	NP_001184249	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001184249
RefSeq	NP_068779	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_068779
RefSeq	NP_877495	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_877495
SMR	Q07820	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q07820
STRING	9606.ENSP00000358022	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000358022&targetmode=cogs
UCSC	uc001euz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001euz&org=rat
UniGene	Hs.632486	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.632486
UniProtKB	MCL1_HUMAN	http://www.uniprot.org/uniprot/MCL1_HUMAN
UniProtKB-AC	Q07820	http://www.uniprot.org/uniprot/Q07820
charge	swissprot:MCL1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MCL1_HUMAN
eggNOG	ENOG41123S0	http://eggnogapi.embl.de/nog_data/html/tree/ENOG41123S0
eggNOG	KOG4728	http://eggnogapi.embl.de/nog_data/html/tree/KOG4728
epestfind	swissprot:MCL1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MCL1_HUMAN
garnier	swissprot:MCL1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MCL1_HUMAN
helixturnhelix	swissprot:MCL1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MCL1_HUMAN
hmoment	swissprot:MCL1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MCL1_HUMAN
iep	swissprot:MCL1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MCL1_HUMAN
inforesidue	swissprot:MCL1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MCL1_HUMAN
neXtProt	NX_Q07820	http://www.nextprot.org/db/entry/NX_Q07820
octanol	swissprot:MCL1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MCL1_HUMAN
pepcoil	swissprot:MCL1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MCL1_HUMAN
pepdigest	swissprot:MCL1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MCL1_HUMAN
pepinfo	swissprot:MCL1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MCL1_HUMAN
pepnet	swissprot:MCL1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MCL1_HUMAN
pepstats	swissprot:MCL1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MCL1_HUMAN
pepwheel	swissprot:MCL1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MCL1_HUMAN
pepwindow	swissprot:MCL1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MCL1_HUMAN
sigcleave	swissprot:MCL1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MCL1_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNKD_HUMAN	Tandem pore domain halothane-inhibited potassium channel 1
# Ensembl	ENST00000282146	ENSP00000282146; ENSG00000152315
# FUNCTION	KCNKD_HUMAN	Potassium channel displaying weak inward rectification in symmetrical K(+) solution. {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0005244	voltage-gated ion channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0005267	potassium channel activity; TAS:Reactome.
# GO_function	GO:0022841	potassium ion leak channel activity; IBA:GO_Central.
# GO_process	GO:0030322	stabilization of membrane potential; IBA:GO_Central.
# GO_process	GO:0071805	potassium ion transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9HB14	HS
# HGNC	HGNC:6275	KCNK13
# InterPro	IPR003280	2pore_dom_K_chnl
# InterPro	IPR005410	2pore_dom_K_chnl_THIK
# InterPro	IPR013099	K_chnl_dom
# KEGG_Brite	ko04040	Ion channels
# MIM	607367	gene
# MISCELLANEOUS	The current is enhanced by arachidonic acid and inhibited by halothane. {ECO	0000250}. 
# Organism	KCNKD_HUMAN	Homo sapiens (Human)
# PRINTS	PR01333	2POREKCHANEL
# PRINTS	PR01588	THIKCHANNEL
# Pfam	PF07885	Ion_trans_2; 2
# Proteomes	UP000005640	Chromosome 14
# Reactome	R-HSA-1299287	Tandem pore domain halothane-inhibited K+ channel (THIK)
# Reactome	R-HSA-5576886	Phase 4 - resting membrane potential
# RecName	KCNKD_HUMAN	Potassium channel subfamily K member 13
# RefSeq	NP_071337	NM_022054.3
# SIMILARITY	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCNKD_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUBUNIT	Homodimer. {ECO	0000305}. 
# UCSC	uc001xye	human
# eggNOG	ENOG410XRZJ	LUCA
# eggNOG	KOG4404	Eukaryota
BLAST	swissprot:KCNKD_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNKD_HUMAN
BioCyc	ZFISH:ENSG00000152315-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000152315-MONOMER
COXPRESdb	56659	http://coxpresdb.jp/data/gene/56659.shtml
CleanEx	HS_KCNK13	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNK13
DOI	10.1038/bjp.2008.213	http://dx.doi.org/10.1038/bjp.2008.213
DOI	10.1074/jbc.M008985200	http://dx.doi.org/10.1074/jbc.M008985200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF287303	http://www.ebi.ac.uk/ena/data/view/AF287303
EMBL	BC012779	http://www.ebi.ac.uk/ena/data/view/BC012779
EMBL	CH471061	http://www.ebi.ac.uk/ena/data/view/CH471061
EMBL	EU978942	http://www.ebi.ac.uk/ena/data/view/EU978942
Ensembl	ENST00000282146	http://www.ensembl.org/id/ENST00000282146
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005244
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_function	GO:0022841	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022841
GO_process	GO:0030322	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030322
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	KCNK13	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNK13
GeneID	56659	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56659
GeneTree	ENSGT00860000133807	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00860000133807
HGNC	HGNC:6275	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6275
HOGENOM	HOG000013227	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000013227&db=HOGENOM6
HOVERGEN	HBG052238	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052238&db=HOVERGEN
HPA	HPA003514	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA003514
InParanoid	Q9HB14	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9HB14
InterPro	IPR003280	http://www.ebi.ac.uk/interpro/entry/IPR003280
InterPro	IPR005410	http://www.ebi.ac.uk/interpro/entry/IPR005410
InterPro	IPR013099	http://www.ebi.ac.uk/interpro/entry/IPR013099
Jabion	56659	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=56659
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:56659	http://www.genome.jp/dbget-bin/www_bget?hsa:56659
KEGG_Orthology	KO:K04922	http://www.genome.jp/dbget-bin/www_bget?KO:K04922
MIM	607367	http://www.ncbi.nlm.nih.gov/omim/607367
OMA	VNWILRK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VNWILRK
OrthoDB	EOG091G06SB	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G06SB
PRINTS	PR01333	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01333
PRINTS	PR01588	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01588
PSORT	swissprot:KCNKD_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNKD_HUMAN
PSORT-B	swissprot:KCNKD_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNKD_HUMAN
PSORT2	swissprot:KCNKD_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNKD_HUMAN
Pfam	PF07885	http://pfam.xfam.org/family/PF07885
PharmGKB	PA30055	http://www.pharmgkb.org/do/serve?objId=PA30055&objCls=Gene
Phobius	swissprot:KCNKD_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNKD_HUMAN
PhylomeDB	Q9HB14	http://phylomedb.org/?seqid=Q9HB14
ProteinModelPortal	Q9HB14	http://www.proteinmodelportal.org/query/uniprot/Q9HB14
PubMed	11060316	http://www.ncbi.nlm.nih.gov/pubmed/11060316
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18516069	http://www.ncbi.nlm.nih.gov/pubmed/18516069
Reactome	R-HSA-1299287	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1299287
Reactome	R-HSA-5576886	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576886
RefSeq	NP_071337	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_071337
SMR	Q9HB14	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9HB14
STRING	9606.ENSP00000282146	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000282146&targetmode=cogs
UCSC	uc001xye	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001xye&org=rat
UniGene	Hs.510191	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.510191
UniProtKB	KCNKD_HUMAN	http://www.uniprot.org/uniprot/KCNKD_HUMAN
UniProtKB-AC	Q9HB14	http://www.uniprot.org/uniprot/Q9HB14
charge	swissprot:KCNKD_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNKD_HUMAN
eggNOG	ENOG410XRZJ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRZJ
eggNOG	KOG4404	http://eggnogapi.embl.de/nog_data/html/tree/KOG4404
epestfind	swissprot:KCNKD_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNKD_HUMAN
garnier	swissprot:KCNKD_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNKD_HUMAN
helixturnhelix	swissprot:KCNKD_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNKD_HUMAN
hmoment	swissprot:KCNKD_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNKD_HUMAN
iep	swissprot:KCNKD_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNKD_HUMAN
inforesidue	swissprot:KCNKD_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNKD_HUMAN
neXtProt	NX_Q9HB14	http://www.nextprot.org/db/entry/NX_Q9HB14
octanol	swissprot:KCNKD_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNKD_HUMAN
pepcoil	swissprot:KCNKD_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNKD_HUMAN
pepdigest	swissprot:KCNKD_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNKD_HUMAN
pepinfo	swissprot:KCNKD_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNKD_HUMAN
pepnet	swissprot:KCNKD_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNKD_HUMAN
pepstats	swissprot:KCNKD_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNKD_HUMAN
pepwheel	swissprot:KCNKD_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNKD_HUMAN
pepwindow	swissprot:KCNKD_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNKD_HUMAN
sigcleave	swissprot:KCNKD_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNKD_HUMAN
## Database	ID	URL or Descriptions
# AltName	VATC1_HUMAN	Vacuolar proton pump subunit C 1
# BioGrid	107011	61
# CDD	cd14785	V-ATPase_C
# ChiTaRS	ATP6V1C1	human
# Ensembl	ENST00000395862	ENSP00000379203; ENSG00000155097
# Ensembl	ENST00000518738	ENSP00000430282; ENSG00000155097
# ExpressionAtlas	P21283	baseline and differential
# FUNCTION	VATC1_HUMAN	Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. 
# GO_component	GO:0000221	vacuolar proton-transporting V-type ATPase, V1 domain; IBA:GO_Central.
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0005886	plasma membrane; ISS:UniProtKB.
# GO_component	GO:0016469	proton-transporting two-sector ATPase complex; TAS:ProtInc.
# GO_component	GO:0031410	cytoplasmic vesicle; IEA:Ensembl.
# GO_component	GO:0045177	apical part of cell; IEA:Ensembl.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005215	transporter activity; NAS:ProtInc.
# GO_function	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism; IBA:GO_Central.
# GO_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism; TAS:ProtInc.
# GO_process	GO:0008286	insulin receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0015991	ATP hydrolysis coupled proton transport; IEA:InterPro.
# GO_process	GO:0015992	proton transport; TAS:ProtInc.
# GO_process	GO:0016241	regulation of macroautophagy; NAS:ParkinsonsUK-UCL.
# GO_process	GO:0033572	transferrin transport; TAS:Reactome.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0090383	phagosome acidification; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P21283	HS
# HGNC	HGNC:856	ATP6V1C1
# INTERACTION	VATC1_HUMAN	P62330 ARF6; NbExp=4; IntAct=EBI-988663, EBI-638181; 
# IntAct	P21283	6
# InterPro	IPR004907	ATPase_V1-cplx_csu
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04966	Collecting duct acid secretion
# KEGG_Pathway	ko05110	Vibrio cholerae infection
# KEGG_Pathway	ko05120	Epithelial cell signaling in Helicobacter pylori infection
# KEGG_Pathway	ko05323	Rheumatoid arthritis
# MIM	603097	gene
# Organism	VATC1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10137	PTHR10137
# PIR	JN0907	JN0907
# Pfam	PF03223	V-ATPase_C
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-1222556	ROS, RNS production in response to bacteria
# Reactome	R-HSA-77387	Insulin receptor recycling
# Reactome	R-HSA-917977	Transferrin endocytosis and recycling
# Reactome	R-HSA-983712	Ion channel transport
# RecName	VATC1_HUMAN	V-type proton ATPase subunit C 1
# RefSeq	NP_001686	NM_001695.4
# SIMILARITY	Belongs to the V-ATPase C subunit family. {ECO	0000305}.
# SUBUNIT	V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components	 a, c, c', c'' and d). 
# SUPFAM	SSF118203	SSF118203
# TCDB	3.A.2.2	the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily
# TISSUE SPECIFICITY	Ubiquitous. {ECO:0000269|PubMed	12384298}. 
# UCSC	uc003ykz	human
# eggNOG	COG5127	LUCA
# eggNOG	KOG2909	Eukaryota
BLAST	swissprot:VATC1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VATC1_HUMAN
BioCyc	MetaCyc:HS08030-MONOMER	http://biocyc.org/getid?id=MetaCyc:HS08030-MONOMER
BioCyc	ZFISH:HS08030-MONOMER	http://biocyc.org/getid?id=ZFISH:HS08030-MONOMER
COXPRESdb	528	http://coxpresdb.jp/data/gene/528.shtml
CleanEx	HS_ATP6V1C1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP6V1C1
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/bbrc.1993.2434	http://dx.doi.org/10.1006/bbrc.1993.2434
DOI	10.1016/S0378-1119(02)00884-3	http://dx.doi.org/10.1016/S0378-1119(02)00884-3
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1073/pnas.241525498	http://dx.doi.org/10.1073/pnas.241525498
DOI	10.1074/mcp.M111.015131	http://dx.doi.org/10.1074/mcp.M111.015131
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF363578	http://www.ebi.ac.uk/ena/data/view/AF363578
EMBL	BC010960	http://www.ebi.ac.uk/ena/data/view/BC010960
EMBL	J05682	http://www.ebi.ac.uk/ena/data/view/J05682
EMBL	X69151	http://www.ebi.ac.uk/ena/data/view/X69151
Ensembl	ENST00000395862	http://www.ensembl.org/id/ENST00000395862
Ensembl	ENST00000518738	http://www.ensembl.org/id/ENST00000518738
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000221	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000221
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016469	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016469
GO_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GO_component	GO:0045177	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045177
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0008553	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008553
GO_function	GO:0046961	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046961
GO_process	GO:0008286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008286
GO_process	GO:0015991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015991
GO_process	GO:0015992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992
GO_process	GO:0016241	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016241
GO_process	GO:0033572	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033572
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0090383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090383
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ATP6V1C1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP6V1C1
GeneID	528	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=528
GeneTree	ENSGT00390000004263	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000004263
HGNC	HGNC:856	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:856
HOGENOM	HOG000207528	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000207528&db=HOGENOM6
HOVERGEN	HBG002470	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG002470&db=HOVERGEN
HPA	HPA023943	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA023943
HPA	HPA057297	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA057297
InParanoid	P21283	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21283
IntAct	P21283	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21283*
InterPro	IPR004907	http://www.ebi.ac.uk/interpro/entry/IPR004907
Jabion	528	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=528
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:528	http://www.genome.jp/dbget-bin/www_bget?hsa:528
KEGG_Orthology	KO:K02148	http://www.genome.jp/dbget-bin/www_bget?KO:K02148
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04966	http://www.genome.jp/kegg-bin/show_pathway?ko04966
KEGG_Pathway	ko05110	http://www.genome.jp/kegg-bin/show_pathway?ko05110
KEGG_Pathway	ko05120	http://www.genome.jp/kegg-bin/show_pathway?ko05120
KEGG_Pathway	ko05323	http://www.genome.jp/kegg-bin/show_pathway?ko05323
MIM	603097	http://www.ncbi.nlm.nih.gov/omim/603097
OMA	TARENKF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TARENKF
OrthoDB	EOG091G03CP	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G03CP
PANTHER	PTHR10137	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10137
PSORT	swissprot:VATC1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VATC1_HUMAN
PSORT-B	swissprot:VATC1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VATC1_HUMAN
PSORT2	swissprot:VATC1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VATC1_HUMAN
Pfam	PF03223	http://pfam.xfam.org/family/PF03223
PharmGKB	PA25156	http://www.pharmgkb.org/do/serve?objId=PA25156&objCls=Gene
Phobius	swissprot:VATC1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VATC1_HUMAN
PhylomeDB	P21283	http://phylomedb.org/?seqid=P21283
ProteinModelPortal	P21283	http://www.proteinmodelportal.org/query/uniprot/P21283
PubMed	11707601	http://www.ncbi.nlm.nih.gov/pubmed/11707601
PubMed	12384298	http://www.ncbi.nlm.nih.gov/pubmed/12384298
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	2147024	http://www.ncbi.nlm.nih.gov/pubmed/2147024
PubMed	22223895	http://www.ncbi.nlm.nih.gov/pubmed/22223895
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	8250920	http://www.ncbi.nlm.nih.gov/pubmed/8250920
Reactome	R-HSA-1222556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1222556
Reactome	R-HSA-77387	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-77387
Reactome	R-HSA-917977	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917977
Reactome	R-HSA-983712	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983712
RefSeq	NP_001686	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001686
SMR	P21283	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21283
STRING	9606.ENSP00000379203	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000379203&targetmode=cogs
SUPFAM	SSF118203	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF118203
TCDB	3.A.2.2	http://www.tcdb.org/search/result.php?tc=3.A.2.2
UCSC	uc003ykz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ykz&org=rat
UniGene	Hs.86905	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.86905
UniProtKB	VATC1_HUMAN	http://www.uniprot.org/uniprot/VATC1_HUMAN
UniProtKB-AC	P21283	http://www.uniprot.org/uniprot/P21283
charge	swissprot:VATC1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VATC1_HUMAN
eggNOG	COG5127	http://eggnogapi.embl.de/nog_data/html/tree/COG5127
eggNOG	KOG2909	http://eggnogapi.embl.de/nog_data/html/tree/KOG2909
epestfind	swissprot:VATC1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VATC1_HUMAN
garnier	swissprot:VATC1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VATC1_HUMAN
helixturnhelix	swissprot:VATC1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VATC1_HUMAN
hmoment	swissprot:VATC1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VATC1_HUMAN
iep	swissprot:VATC1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VATC1_HUMAN
inforesidue	swissprot:VATC1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VATC1_HUMAN
neXtProt	NX_P21283	http://www.nextprot.org/db/entry/NX_P21283
octanol	swissprot:VATC1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VATC1_HUMAN
pepcoil	swissprot:VATC1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VATC1_HUMAN
pepdigest	swissprot:VATC1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VATC1_HUMAN
pepinfo	swissprot:VATC1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VATC1_HUMAN
pepnet	swissprot:VATC1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VATC1_HUMAN
pepstats	swissprot:VATC1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VATC1_HUMAN
pepwheel	swissprot:VATC1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VATC1_HUMAN
pepwindow	swissprot:VATC1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VATC1_HUMAN
sigcleave	swissprot:VATC1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VATC1_HUMAN
## Database	ID	URL or Descriptions
# AltName	SL9A2_HUMAN	Na(+)/H(+) exchanger 2
# AltName	SL9A2_HUMAN	Solute carrier family 9 member 2
# BioGrid	112439	6
# CAUTION	The number, localization and denomination of hydrophobic domains in the Na(+)/H(+) exchangers vary among authors. {ECO	0000305}.
# Ensembl	ENST00000233969	ENSP00000233969; ENSG00000115616
# FUNCTION	SL9A2_HUMAN	Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption. 
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_function	SL9A2_HUMAN	GO 0015385 sodium proton antiporter activity; TAS Reactome.
# GO_function	SL9A2_HUMAN	GO 0015386 potassium proton antiporter activity; IBA GO_Central.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0008104	protein localization; IEA:Ensembl.
# GO_process	GO:0051453	regulation of intracellular pH; IBA:GO_Central.
# GO_process	GO:0071805	potassium ion transmembrane transport; IBA:GO_Central.
# GO_process	GO:0098719	sodium ion import across plasma membrane; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9UBY0	HS
# HGNC	HGNC:11072	SLC9A2
# InterPro	IPR001953	Na/H_exchanger_2
# InterPro	IPR004709	NaH_exchanger
# InterPro	IPR006153	Cation/H_exchanger
# InterPro	IPR018422	Cation/H_exchanger_CPA1
# InterPro	IPR032103	NHE_CaM-bd
# KEGG_Brite	ko02001	Solute carrier family
# MIM	600530	gene
# Organism	SL9A2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10110	PTHR10110
# PRINTS	PR01084	NAHEXCHNGR
# PRINTS	PR01086	NAHEXCHNGR2
# PTM	SL9A2_HUMAN	Phosphorylated (Possible). 
# Pfam	PF00999	Na_H_Exchanger
# Pfam	PF16644	NEXCaM_BD
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-425986	Sodium/Proton exchangers
# RecName	SL9A2_HUMAN	Sodium/hydrogen exchanger 2
# RefSeq	NP_003039	NM_003048.5
# SIMILARITY	Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	SL9A2_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Interacts with CHP1 and CHP2. {ECO	0000250}. 
# TCDB	2.A.36.1.17:the monovalent cation	proton antiporter-1 (cpa1) family
# TIGRFAMs	TIGR00840	b_cpa1
# TISSUE SPECIFICITY	SL9A2_HUMAN	Expressed in skeletal muscle, colon and kidney. Lower levels in the testis, prostate, ovary, and small intestine. 
# UCSC	uc002tca	human
# eggNOG	COG0025	LUCA
# eggNOG	KOG1966	Eukaryota
BLAST	swissprot:SL9A2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SL9A2_HUMAN
BioCyc	ZFISH:ENSG00000115616-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000115616-MONOMER
COXPRESdb	6549	http://coxpresdb.jp/data/gene/6549.shtml
CleanEx	HS_SLC9A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC9A2
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
EMBL	AC007239	http://www.ebi.ac.uk/ena/data/view/AC007239
EMBL	AF073299	http://www.ebi.ac.uk/ena/data/view/AF073299
EMBL	BC136377	http://www.ebi.ac.uk/ena/data/view/BC136377
EMBL	BC136378	http://www.ebi.ac.uk/ena/data/view/BC136378
EMBL	CH471127	http://www.ebi.ac.uk/ena/data/view/CH471127
Ensembl	ENST00000233969	http://www.ensembl.org/id/ENST00000233969
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015385
GO_function	GO:0015386	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015386
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0008104	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008104
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GO_process	GO:0098719	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098719
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC9A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC9A2
GeneID	6549	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6549
GeneTree	ENSGT00760000119074	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119074
HGNC	HGNC:11072	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11072
HOGENOM	HOG000247044	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000247044&db=HOGENOM6
HOVERGEN	HBG052615	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052615&db=HOVERGEN
HPA	HPA035121	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035121
HPA	HPA035122	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035122
InParanoid	Q9UBY0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UBY0
IntAct	Q9UBY0	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9UBY0*
InterPro	IPR001953	http://www.ebi.ac.uk/interpro/entry/IPR001953
InterPro	IPR004709	http://www.ebi.ac.uk/interpro/entry/IPR004709
InterPro	IPR006153	http://www.ebi.ac.uk/interpro/entry/IPR006153
InterPro	IPR018422	http://www.ebi.ac.uk/interpro/entry/IPR018422
InterPro	IPR032103	http://www.ebi.ac.uk/interpro/entry/IPR032103
Jabion	6549	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6549
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6549	http://www.genome.jp/dbget-bin/www_bget?hsa:6549
KEGG_Orthology	KO:K14722	http://www.genome.jp/dbget-bin/www_bget?KO:K14722
MIM	600530	http://www.ncbi.nlm.nih.gov/omim/600530
OMA	AYKMEWK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AYKMEWK
OrthoDB	EOG091G02Q0	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02Q0
PANTHER	PTHR10110	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10110
PRINTS	PR01084	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01084
PRINTS	PR01086	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01086
PSORT	swissprot:SL9A2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SL9A2_HUMAN
PSORT-B	swissprot:SL9A2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SL9A2_HUMAN
PSORT2	swissprot:SL9A2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SL9A2_HUMAN
Pfam	PF00999	http://pfam.xfam.org/family/PF00999
Pfam	PF16644	http://pfam.xfam.org/family/PF16644
PharmGKB	PA35929	http://www.pharmgkb.org/do/serve?objId=PA35929&objCls=Gene
Phobius	swissprot:SL9A2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SL9A2_HUMAN
PhylomeDB	Q9UBY0	http://phylomedb.org/?seqid=Q9UBY0
ProteinModelPortal	Q9UBY0	http://www.proteinmodelportal.org/query/uniprot/Q9UBY0
PubMed	10444453	http://www.ncbi.nlm.nih.gov/pubmed/10444453
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
Reactome	R-HSA-425986	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425986
RefSeq	NP_003039	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003039
SMR	Q9UBY0	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9UBY0
STRING	9606.ENSP00000233969	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000233969&targetmode=cogs
TCDB	2.A.36.1.17	http://www.tcdb.org/search/result.php?tc=2.A.36.1.17
TIGRFAMs	TIGR00840	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00840
UCSC	uc002tca	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002tca&org=rat
UniGene	Hs.250083	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.250083
UniProtKB	SL9A2_HUMAN	http://www.uniprot.org/uniprot/SL9A2_HUMAN
UniProtKB-AC	Q9UBY0	http://www.uniprot.org/uniprot/Q9UBY0
charge	swissprot:SL9A2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SL9A2_HUMAN
eggNOG	COG0025	http://eggnogapi.embl.de/nog_data/html/tree/COG0025
eggNOG	KOG1966	http://eggnogapi.embl.de/nog_data/html/tree/KOG1966
epestfind	swissprot:SL9A2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SL9A2_HUMAN
garnier	swissprot:SL9A2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SL9A2_HUMAN
helixturnhelix	swissprot:SL9A2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SL9A2_HUMAN
hmoment	swissprot:SL9A2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SL9A2_HUMAN
iep	swissprot:SL9A2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SL9A2_HUMAN
inforesidue	swissprot:SL9A2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SL9A2_HUMAN
neXtProt	NX_Q9UBY0	http://www.nextprot.org/db/entry/NX_Q9UBY0
octanol	swissprot:SL9A2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SL9A2_HUMAN
pepcoil	swissprot:SL9A2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SL9A2_HUMAN
pepdigest	swissprot:SL9A2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SL9A2_HUMAN
pepinfo	swissprot:SL9A2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SL9A2_HUMAN
pepnet	swissprot:SL9A2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SL9A2_HUMAN
pepstats	swissprot:SL9A2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SL9A2_HUMAN
pepwheel	swissprot:SL9A2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SL9A2_HUMAN
pepwindow	swissprot:SL9A2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SL9A2_HUMAN
sigcleave	swissprot:SL9A2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SL9A2_HUMAN
## Database	ID	URL or Descriptions
# AltName	AT1A2_HUMAN	Sodium pump subunit alpha-2
# BioGrid	106967	19
# CATALYTIC ACTIVITY	AT1A2_HUMAN	ATP + H(2)O + Na(+)(In) + K(+)(Out) = ADP + phosphate + Na(+)(Out) + K(+)(In). 
# ChiTaRS	ATP1A2	human
# DISEASE	AT1A2_HUMAN	Alternating hemiplegia of childhood 1 (AHC1) [MIM 104290]  A rare syndrome of episodic hemi- or quadriplegia lasting minutes to days. Most cases are accompanied by dystonic posturing, choreoathetoid movements, nystagmus, other ocular motor abnormalities, autonomic disturbances, and progressive cognitive impairment. It is typically distinguished from familial hemiplegic migraine by infantile onset and high prevalence of associated neurological deficits that become increasingly obvious with age. {ECO 0000269|PubMed 15174025}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	AT1A2_HUMAN	Migraine, familial hemiplegic, 2 (FHM2) [MIM 602481]  A subtype of migraine with aura associated with hemiparesis in some families. Migraine is a disabling symptom complex of periodic headaches, usually temporal and unilateral. Headaches are often accompanied by irritability, nausea, vomiting and photophobia, preceded by constriction of the cranial arteries. Migraine with aura is characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as blurred vision, hallucinations, vertigo, numbness and difficulty in concentrating and speaking. {ECO 0000269|PubMed 12539047, ECO 0000269|PubMed 12953268, ECO 0000269|PubMed 21352219, ECO 0000269|PubMed 23838748, ECO 0000269|PubMed 23918834}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000361216	ENSP00000354490; ENSG00000018625
# ExpressionAtlas	P50993	baseline and differential
# FUNCTION	AT1A2_HUMAN	This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. 
# GO_component	AT1A2_HUMAN	GO 0005890 sodium potassium-exchanging ATPase complex; IC UniProtKB.
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005768	endosome; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005901	caveola; IEA:Ensembl.
# GO_component	GO:0014704	intercalated disc; IEA:Ensembl.
# GO_component	GO:0016020	membrane; IDA:BHF-UCL.
# GO_component	GO:0030315	T-tubule; IEA:Ensembl.
# GO_component	GO:0043197	dendritic spine; IEA:Ensembl.
# GO_component	GO:0043209	myelin sheath; IEA:Ensembl.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IBA:GO_Central.
# GO_component	GO:1903561	extracellular vesicle; IDA:UniProtKB.
# GO_function	AT1A2_HUMAN	GO 0005391 sodium potassium-exchanging ATPase activity; IMP UniProtKB.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_function	GO:0051087	chaperone binding; IPI:BHF-UCL.
# GO_function	GO:1990239	steroid hormone binding; IDA:BHF-UCL.
# GO_process	AT1A2_HUMAN	GO 1903280 negative regulation of calcium sodium antiporter activity; ISS BHF-UCL.
# GO_process	GO:0001504	neurotransmitter uptake; IEA:Ensembl.
# GO_process	GO:0002026	regulation of the force of heart contraction; IEA:Ensembl.
# GO_process	GO:0002087	regulation of respiratory gaseous exchange by neurological system process; IEA:Ensembl.
# GO_process	GO:0006813	potassium ion transport; NAS:UniProtKB.
# GO_process	GO:0006814	sodium ion transport; NAS:UniProtKB.
# GO_process	GO:0006883	cellular sodium ion homeostasis; IDA:BHF-UCL.
# GO_process	GO:0006940	regulation of smooth muscle contraction; IEA:Ensembl.
# GO_process	GO:0006942	regulation of striated muscle contraction; NAS:UniProtKB.
# GO_process	GO:0008217	regulation of blood pressure; IEA:Ensembl.
# GO_process	GO:0008344	adult locomotory behavior; IEA:Ensembl.
# GO_process	GO:0008542	visual learning; IEA:Ensembl.
# GO_process	GO:0010107	potassium ion import; IDA:BHF-UCL.
# GO_process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; TAS:BHF-UCL.
# GO_process	GO:0015991	ATP hydrolysis coupled proton transport; IBA:GO_Central.
# GO_process	GO:0019229	regulation of vasoconstriction; IEA:Ensembl.
# GO_process	GO:0030007	cellular potassium ion homeostasis; IDA:BHF-UCL.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0035094	response to nicotine; IEA:Ensembl.
# GO_process	GO:0036376	sodium ion export from cell; IDA:BHF-UCL.
# GO_process	GO:0040011	locomotion; IEA:Ensembl.
# GO_process	GO:0045822	negative regulation of heart contraction; IEA:Ensembl.
# GO_process	GO:0045988	negative regulation of striated muscle contraction; IEA:Ensembl.
# GO_process	GO:0046034	ATP metabolic process; IMP:BHF-UCL.
# GO_process	GO:0051481	negative regulation of cytosolic calcium ion concentration; IEA:Ensembl.
# GO_process	GO:0051946	regulation of glutamate uptake involved in transmission of nerve impulse; NAS:BHF-UCL.
# GO_process	GO:0051966	regulation of synaptic transmission, glutamatergic; NAS:BHF-UCL.
# GO_process	GO:0055119	relaxation of cardiac muscle; TAS:BHF-UCL.
# GO_process	GO:0060048	cardiac muscle contraction; TAS:BHF-UCL.
# GO_process	GO:0071260	cellular response to mechanical stimulus; IEA:Ensembl.
# GO_process	GO:0071383	cellular response to steroid hormone stimulus; IDA:BHF-UCL.
# GO_process	GO:0086004	regulation of cardiac muscle cell contraction; IEA:Ensembl.
# GO_process	GO:0086009	membrane repolarization; TAS:BHF-UCL.
# GO_process	GO:0086012	membrane depolarization during cardiac muscle cell action potential; TAS:BHF-UCL.
# GO_process	GO:0086064	cell communication by electrical coupling involved in cardiac conduction; TAS:BHF-UCL.
# GO_process	GO:1903170	negative regulation of calcium ion transmembrane transport; ISS:BHF-UCL.
# GO_process	GO:1903416	response to glycoside; ISS:BHF-UCL.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GO_process	GO:1990573	potassium ion import across plasma membrane; IC:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008289	lipid binding
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0003013	circulatory system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0040011	locomotion
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.1110.10	-; 2.
# Gene3D	2.70.150.10	-; 2.
# Gene3D	3.40.1110.10	-; 1.
# Genevisible	P50993	HS
# HGNC	HGNC:800	ATP1A2
# IntAct	P50993	2
# InterPro	IPR001757	P_typ_ATPase
# InterPro	IPR004014	ATPase_P-typ_cation-transptr_N
# InterPro	IPR005775	P-type_ATPase_IIC
# InterPro	IPR006068	ATPase_P-typ_cation-transptr_C
# InterPro	IPR008250	ATPase_P-typ_transduc_dom_A
# InterPro	IPR018303	ATPase_P-typ_P_site
# InterPro	IPR023214	HAD-like_dom
# InterPro	IPR023298	ATPase_P-typ_TM_dom
# InterPro	IPR023299	ATPase_P-typ_cyto_domN
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Disease	H00775	[Nervous system disease] Familial or sporadic hemiplegic migraine
# KEGG_Disease	H00998	[Nervous system disease] Alternating hemiplegia of childhood
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko04960	Aldosterone-regulated sodium reabsorption
# KEGG_Pathway	ko04961	Endocrine and other factor-regulated calcium reabsorption
# KEGG_Pathway	ko04964	Proximal tubule bicarbonate reclamation
# KEGG_Pathway	ko04970	Salivary secretion
# KEGG_Pathway	ko04971	Gastric acid secretion
# KEGG_Pathway	ko04972	Pancreatic secretion
# KEGG_Pathway	ko04973	Carbohydrate digestion and absorption
# KEGG_Pathway	ko04974	Protein digestion and absorption
# KEGG_Pathway	ko04976	Bile secretion
# KEGG_Pathway	ko04978	Mineral absorption
# MIM	104290	phenotype
# MIM	182340	gene
# MIM	602481	phenotype
# Organism	AT1A2_HUMAN	Homo sapiens (Human)
# Orphanet	2131	Alternating hemiplegia of childhood
# Orphanet	569	Familial or sporadic hemiplegic migraine
# PIR	A34474	A34474
# PROSITE	PS00154	ATPASE_E1_E2
# Pfam	PF00122	E1-E2_ATPase
# Pfam	PF00689	Cation_ATPase_C
# Pfam	PF00690	Cation_ATPase_N
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-5578775	Ion homeostasis
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	AT1A2_HUMAN	Sodium/potassium-transporting ATPase subunit alpha-2
# RefSeq	NP_000693	NM_000702.3
# SEQUENCE CAUTION	Sequence=BAA34498.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. {ECO	0000305}. 
# SMART	SM00831	Cation_ATPase_N
# SUBCELLULAR LOCATION	AT1A2_HUMAN	Membrane {ECO 0000269|PubMed 7711835}; Multi-pass membrane protein {ECO 0000269|PubMed 7711835}. Cell membrane {ECO 0000269|PubMed 7711835}; Multi-pass membrane protein {ECO 0000269|PubMed 7711835}. 
# SUBUNIT	Composed of three subunits	 alpha (catalytic), beta and gamma. 
# SUPFAM	SSF56784	SSF56784; 2
# SUPFAM	SSF81660	SSF81660
# TCDB	3.A.3.1	the p-type atpase (p-atpase) superfamily
# TIGRFAMs	TIGR01106	ATPase-IIC_X-K
# TIGRFAMs	TIGR01494	ATPase_P-type; 2
# UCSC	uc001fvc	human
# eggNOG	COG0474	LUCA
# eggNOG	KOG0203	Eukaryota
BLAST	swissprot:AT1A2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AT1A2_HUMAN
BioCyc	ZFISH:HS00391-MONOMER	http://biocyc.org/getid?id=ZFISH:HS00391-MONOMER
COXPRESdb	477	http://coxpresdb.jp/data/gene/477.shtml
CleanEx	HS_ATP1A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP1A2
DOI	10.1002/ana.10674	http://dx.doi.org/10.1002/ana.10674
DOI	10.1002/ana.20134	http://dx.doi.org/10.1002/ana.20134
DOI	10.1016/0014-5793(87)80677-4	http://dx.doi.org/10.1016/0014-5793(87)80677-4
DOI	10.1016/0014-5793(89)80588-5	http://dx.doi.org/10.1016/0014-5793(89)80588-5
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1081	http://dx.doi.org/10.1038/ng1081
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.84.12.4039	http://dx.doi.org/10.1073/pnas.84.12.4039
DOI	10.1093/dnares/5.5.277	http://dx.doi.org/10.1093/dnares/5.5.277
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1526-4610.2010.01793.x	http://dx.doi.org/10.1111/j.1526-4610.2010.01793.x
DOI	10.1177/0333102413495116	http://dx.doi.org/10.1177/0333102413495116
DOI	10.1177/0333102413498941	http://dx.doi.org/10.1177/0333102413498941
DOI	10.3109/09687689409160435	http://dx.doi.org/10.3109/09687689409160435
EC_number	EC:3.6.3.9	http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.9
EMBL	AB018321	http://www.ebi.ac.uk/ena/data/view/AB018321
EMBL	AL121987	http://www.ebi.ac.uk/ena/data/view/AL121987
EMBL	BC052271	http://www.ebi.ac.uk/ena/data/view/BC052271
EMBL	CH471121	http://www.ebi.ac.uk/ena/data/view/CH471121
EMBL	CH471121	http://www.ebi.ac.uk/ena/data/view/CH471121
EMBL	J05096	http://www.ebi.ac.uk/ena/data/view/J05096
EMBL	M16795	http://www.ebi.ac.uk/ena/data/view/M16795
EMBL	M27571	http://www.ebi.ac.uk/ena/data/view/M27571
EMBL	M27576	http://www.ebi.ac.uk/ena/data/view/M27576
EMBL	M27578	http://www.ebi.ac.uk/ena/data/view/M27578
EMBL	Y07494	http://www.ebi.ac.uk/ena/data/view/Y07494
ENZYME	3.6.3.9	http://enzyme.expasy.org/EC/3.6.3.9
Ensembl	ENST00000361216	http://www.ensembl.org/id/ENST00000361216
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005890
GO_component	GO:0005901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005901
GO_component	GO:0014704	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014704
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0030315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030315
GO_component	GO:0043197	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043197
GO_component	GO:0043209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043209
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_component	GO:1903561	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903561
GO_function	GO:0005391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005391
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_function	GO:0051087	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051087
GO_function	GO:1990239	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990239
GO_process	GO:0001504	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001504
GO_process	GO:0002026	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002026
GO_process	GO:0002087	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002087
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0006883	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006883
GO_process	GO:0006940	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006940
GO_process	GO:0006942	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006942
GO_process	GO:0008217	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008217
GO_process	GO:0008344	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008344
GO_process	GO:0008542	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008542
GO_process	GO:0010107	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010107
GO_process	GO:0010881	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010881
GO_process	GO:0015991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015991
GO_process	GO:0019229	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019229
GO_process	GO:0030007	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030007
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0035094	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035094
GO_process	GO:0036376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036376
GO_process	GO:0040011	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011
GO_process	GO:0045822	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045822
GO_process	GO:0045988	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045988
GO_process	GO:0046034	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046034
GO_process	GO:0051481	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051481
GO_process	GO:0051946	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051946
GO_process	GO:0051966	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051966
GO_process	GO:0055119	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055119
GO_process	GO:0060048	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060048
GO_process	GO:0071260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071260
GO_process	GO:0071383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071383
GO_process	GO:0086004	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086004
GO_process	GO:0086009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086009
GO_process	GO:0086012	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086012
GO_process	GO:0086064	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086064
GO_process	GO:1903170	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903170
GO_process	GO:1903280	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903280
GO_process	GO:1903416	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903416
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GO_process	GO:1990573	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990573
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0003013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003013
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0040011	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.1110.10	http://www.cathdb.info/version/latest/superfamily/1.20.1110.10
Gene3D	2.70.150.10	http://www.cathdb.info/version/latest/superfamily/2.70.150.10
Gene3D	3.40.1110.10	http://www.cathdb.info/version/latest/superfamily/3.40.1110.10
GeneCards	ATP1A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP1A2
GeneID	477	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=477
GeneTree	ENSGT00850000132256	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00850000132256
HGNC	HGNC:800	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:800
HOGENOM	HOG000265622	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265622&db=HOGENOM6
HOVERGEN	HBG004298	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004298&db=HOVERGEN
HPA	CAB022230	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB022230
InParanoid	P50993	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P50993
IntAct	P50993	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P50993*
IntEnz	3.6.3.9	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.9
InterPro	IPR001757	http://www.ebi.ac.uk/interpro/entry/IPR001757
InterPro	IPR004014	http://www.ebi.ac.uk/interpro/entry/IPR004014
InterPro	IPR005775	http://www.ebi.ac.uk/interpro/entry/IPR005775
InterPro	IPR006068	http://www.ebi.ac.uk/interpro/entry/IPR006068
InterPro	IPR008250	http://www.ebi.ac.uk/interpro/entry/IPR008250
InterPro	IPR018303	http://www.ebi.ac.uk/interpro/entry/IPR018303
InterPro	IPR023214	http://www.ebi.ac.uk/interpro/entry/IPR023214
InterPro	IPR023298	http://www.ebi.ac.uk/interpro/entry/IPR023298
InterPro	IPR023299	http://www.ebi.ac.uk/interpro/entry/IPR023299
Jabion	477	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=477
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Disease	H00775	http://www.genome.jp/dbget-bin/www_bget?H00775
KEGG_Disease	H00998	http://www.genome.jp/dbget-bin/www_bget?H00998
KEGG_Gene	hsa:477	http://www.genome.jp/dbget-bin/www_bget?hsa:477
KEGG_Orthology	KO:K01539	http://www.genome.jp/dbget-bin/www_bget?KO:K01539
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko04960	http://www.genome.jp/kegg-bin/show_pathway?ko04960
KEGG_Pathway	ko04961	http://www.genome.jp/kegg-bin/show_pathway?ko04961
KEGG_Pathway	ko04964	http://www.genome.jp/kegg-bin/show_pathway?ko04964
KEGG_Pathway	ko04970	http://www.genome.jp/kegg-bin/show_pathway?ko04970
KEGG_Pathway	ko04971	http://www.genome.jp/kegg-bin/show_pathway?ko04971
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
KEGG_Pathway	ko04973	http://www.genome.jp/kegg-bin/show_pathway?ko04973
KEGG_Pathway	ko04974	http://www.genome.jp/kegg-bin/show_pathway?ko04974
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
KEGG_Pathway	ko04978	http://www.genome.jp/kegg-bin/show_pathway?ko04978
MIM	104290	http://www.ncbi.nlm.nih.gov/omim/104290
MIM	182340	http://www.ncbi.nlm.nih.gov/omim/182340
MIM	602481	http://www.ncbi.nlm.nih.gov/omim/602481
OMA	MREAFNN	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MREAFNN
Orphanet	2131	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=2131
Orphanet	569	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=569
OrthoDB	EOG091G01BB	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01BB
PROSITE	PS00154	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00154
PSORT	swissprot:AT1A2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AT1A2_HUMAN
PSORT-B	swissprot:AT1A2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AT1A2_HUMAN
PSORT2	swissprot:AT1A2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AT1A2_HUMAN
Pfam	PF00122	http://pfam.xfam.org/family/PF00122
Pfam	PF00689	http://pfam.xfam.org/family/PF00689
Pfam	PF00690	http://pfam.xfam.org/family/PF00690
PharmGKB	PA30796	http://www.pharmgkb.org/do/serve?objId=PA30796&objCls=Gene
Phobius	swissprot:AT1A2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AT1A2_HUMAN
PhylomeDB	P50993	http://phylomedb.org/?seqid=P50993
ProteinModelPortal	P50993	http://www.proteinmodelportal.org/query/uniprot/P50993
PubMed	12539047	http://www.ncbi.nlm.nih.gov/pubmed/12539047
PubMed	12953268	http://www.ncbi.nlm.nih.gov/pubmed/12953268
PubMed	15174025	http://www.ncbi.nlm.nih.gov/pubmed/15174025
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	21352219	http://www.ncbi.nlm.nih.gov/pubmed/21352219
PubMed	23838748	http://www.ncbi.nlm.nih.gov/pubmed/23838748
PubMed	23918834	http://www.ncbi.nlm.nih.gov/pubmed/23918834
PubMed	2477373	http://www.ncbi.nlm.nih.gov/pubmed/2477373
PubMed	2537767	http://www.ncbi.nlm.nih.gov/pubmed/2537767
PubMed	3035563	http://www.ncbi.nlm.nih.gov/pubmed/3035563
PubMed	3036582	http://www.ncbi.nlm.nih.gov/pubmed/3036582
PubMed	7711835	http://www.ncbi.nlm.nih.gov/pubmed/7711835
PubMed	9872452	http://www.ncbi.nlm.nih.gov/pubmed/9872452
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_000693	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000693
SMART	SM00831	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00831
SMR	P50993	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P50993
STRING	9606.ENSP00000354490	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000354490&targetmode=cogs
SUPFAM	SSF56784	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784
SUPFAM	SSF81660	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81660
TCDB	3.A.3.1	http://www.tcdb.org/search/result.php?tc=3.A.3.1
TIGRFAMs	TIGR01106	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01106
TIGRFAMs	TIGR01494	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01494
UCSC	uc001fvc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001fvc&org=rat
UniGene	Hs.34114	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.34114
UniProtKB	AT1A2_HUMAN	http://www.uniprot.org/uniprot/AT1A2_HUMAN
UniProtKB-AC	P50993	http://www.uniprot.org/uniprot/P50993
charge	swissprot:AT1A2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AT1A2_HUMAN
eggNOG	COG0474	http://eggnogapi.embl.de/nog_data/html/tree/COG0474
eggNOG	KOG0203	http://eggnogapi.embl.de/nog_data/html/tree/KOG0203
epestfind	swissprot:AT1A2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AT1A2_HUMAN
garnier	swissprot:AT1A2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AT1A2_HUMAN
helixturnhelix	swissprot:AT1A2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AT1A2_HUMAN
hmoment	swissprot:AT1A2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AT1A2_HUMAN
iep	swissprot:AT1A2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AT1A2_HUMAN
inforesidue	swissprot:AT1A2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AT1A2_HUMAN
neXtProt	NX_P50993	http://www.nextprot.org/db/entry/NX_P50993
octanol	swissprot:AT1A2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AT1A2_HUMAN
pepcoil	swissprot:AT1A2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AT1A2_HUMAN
pepdigest	swissprot:AT1A2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AT1A2_HUMAN
pepinfo	swissprot:AT1A2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AT1A2_HUMAN
pepnet	swissprot:AT1A2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AT1A2_HUMAN
pepstats	swissprot:AT1A2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AT1A2_HUMAN
pepwheel	swissprot:AT1A2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AT1A2_HUMAN
pepwindow	swissprot:AT1A2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AT1A2_HUMAN
sigcleave	swissprot:AT1A2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AT1A2_HUMAN
## Database	ID	URL or Descriptions
# AltName	MCLN1_HUMAN	MG-2
# AltName	MCLN1_HUMAN	Mucolipidin
# BioGrid	121441	4
# ChiTaRS	MCOLN1	human
# DISEASE	MCLN1_HUMAN	Mucolipidosis 4 (ML4) [MIM 252650]  An autosomal recessive lysosomal storage disorder characterized by severe psychomotor retardation and ophthalmologic abnormalities, including corneal opacity, retinal degeneration and strabismus. Storage bodies of lipids and water-soluble substances are seen by electron microscopy in almost every cell type of the patients. Most patients are unable to speak or walk independently and reach a maximal developmental level of 1-2 years. All patients have constitutive achlorhydia associated with a secondary elevation of serum gastrin levels. {ECO 0000269|PubMed 11030752, ECO 0000269|PubMed 11317355, ECO 0000269|PubMed 12182165, ECO 0000269|PubMed 15523648}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# ENZYME REGULATION	MCLN1_HUMAN	Channel function is transiently modulated by changes in Ca(2+), and inhibited by a reduction of pH; pH changes modify the aggregation state of unitary channels. 
# Ensembl	ENST00000264079	ENSP00000264079; ENSG00000090674
# ExpressionAtlas	Q9GZU1	baseline and differential
# FUNCTION	MCLN1_HUMAN	Cation channel probably playing a role in the endocytic pathway and in the control of membrane trafficking of proteins and lipids. Could play a major role in Ca(2+) transport regulating lysosomal exocytosis. {ECO 0000269|PubMed 12459486, ECO 0000269|PubMed 14749347}. 
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:HPA.
# GO_component	GO:0005887	integral component of plasma membrane; NAS:UniProtKB.
# GO_component	GO:0010008	endosome membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0031902	late endosome membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0043235	receptor complex; IDA:MGI.
# GO_function	GO:0005261	cation channel activity; NAS:UniProtKB.
# GO_function	GO:0005262	calcium channel activity; TAS:Reactome.
# GO_function	GO:0005381	iron ion transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0072345	NAADP-sensitive calcium-release channel activity; IEA:Ensembl.
# GO_process	GO:0006812	cation transport; NAS:UniProtKB.
# GO_process	GO:0033572	transferrin transport; TAS:Reactome.
# GO_process	GO:0070588	calcium ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0097352	autophagosome maturation; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9GZU1	HS
# HGNC	HGNC:13356	MCOLN1
# IntAct	Q9GZU1	3
# InterPro	IPR013122	PKD1_2_channel
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00144	[Inherited metabolic disease; Nervous system disease; Lysosomal storage disease] Mucolipidosis IV
# KEGG_Pathway	ko04142	Lysosome
# MIM	252650	phenotype
# MIM	605248	gene
# Organism	MCLN1_HUMAN	Homo sapiens (Human)
# Orphanet	578	Mucolipidosis type 4
# Pfam	PF08016	PKD_channel
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-3295583	TRP channels
# Reactome	R-HSA-917977	Transferrin endocytosis and recycling
# RecName	MCLN1_HUMAN	Mucolipin-1
# RefSeq	NP_065394	NM_020533.2
# SEQUENCE CAUTION	MCLN1_HUMAN	Sequence=AAQ13604.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=CAC07813.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO 0000305}; Sequence=EAW69031.1; Type=Erroneous gene model prediction; Evidence={ECO 0000305}; Sequence=EAW69034.1; Type=Erroneous gene model prediction; Evidence={ECO 0000305};
# SIMILARITY	Belongs to the transient receptor (TC 1.A.4) family. Polycystin subfamily. MCOLN1 sub-subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	MCLN1_HUMAN	Cell membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. 
# SUBUNIT	MCLN1_HUMAN	Forms multimeric complexes. Interacts with PDCD6. {ECO 0000269|PubMed 14749347, ECO 0000269|PubMed 19864416}. 
# TCDB	1.A.5.3	the polycystin cation channel (pcc) family
# TISSUE SPECIFICITY	MCLN1_HUMAN	Widely expressed in adult and fetal tissues. {ECO 0000269|PubMed 10973263, ECO 0000269|PubMed 11013137, ECO 0000269|PubMed 11030752}. 
# UCSC	uc002mgo	human
# eggNOG	ENOG410Z1HH	LUCA
# eggNOG	KOG3733	Eukaryota
BLAST	swissprot:MCLN1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MCLN1_HUMAN
COXPRESdb	57192	http://coxpresdb.jp/data/gene/57192.shtml
CleanEx	HS_MCOLN1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_MCOLN1
DOI	10.1002/humu.1115	http://dx.doi.org/10.1002/humu.1115
DOI	10.1002/humu.20094	http://dx.doi.org/10.1002/humu.20094
DOI	10.1016/S0014-5793(02)03670-0	http://dx.doi.org/10.1016/S0014-5793(02)03670-0
DOI	10.1016/j.febslet.2004.04.080	http://dx.doi.org/10.1016/j.febslet.2004.04.080
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/79095	http://dx.doi.org/10.1038/79095
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M109.047241	http://dx.doi.org/10.1074/jbc.M109.047241
DOI	10.1086/321205	http://dx.doi.org/10.1086/321205
DOI	10.1093/hmg/9.17.2471	http://dx.doi.org/10.1093/hmg/9.17.2471
DOI	10.1093/hmg/ddh067	http://dx.doi.org/10.1093/hmg/ddh067
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1600-0854.2007.00643.x	http://dx.doi.org/10.1111/j.1600-0854.2007.00643.x
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1212/WNL.59.3.306	http://dx.doi.org/10.1212/WNL.59.3.306
EMBL	AF171088	http://www.ebi.ac.uk/ena/data/view/AF171088
EMBL	AF249319	http://www.ebi.ac.uk/ena/data/view/AF249319
EMBL	AF287269	http://www.ebi.ac.uk/ena/data/view/AF287269
EMBL	AF287270	http://www.ebi.ac.uk/ena/data/view/AF287270
EMBL	AF305572	http://www.ebi.ac.uk/ena/data/view/AF305572
EMBL	AF305573	http://www.ebi.ac.uk/ena/data/view/AF305573
EMBL	AF305574	http://www.ebi.ac.uk/ena/data/view/AF305574
EMBL	AF305575	http://www.ebi.ac.uk/ena/data/view/AF305575
EMBL	AF305576	http://www.ebi.ac.uk/ena/data/view/AF305576
EMBL	AF305577	http://www.ebi.ac.uk/ena/data/view/AF305577
EMBL	AF305578	http://www.ebi.ac.uk/ena/data/view/AF305578
EMBL	AF305579	http://www.ebi.ac.uk/ena/data/view/AF305579
EMBL	AJ293659	http://www.ebi.ac.uk/ena/data/view/AJ293659
EMBL	AJ293970	http://www.ebi.ac.uk/ena/data/view/AJ293970
EMBL	AK026102	http://www.ebi.ac.uk/ena/data/view/AK026102
EMBL	BC005149	http://www.ebi.ac.uk/ena/data/view/BC005149
EMBL	CH471139	http://www.ebi.ac.uk/ena/data/view/CH471139
EMBL	CH471139	http://www.ebi.ac.uk/ena/data/view/CH471139
Ensembl	ENST00000264079	http://www.ensembl.org/id/ENST00000264079
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0010008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010008
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0031902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031902
GO_component	GO:0043235	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043235
GO_function	GO:0005261	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005261
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0005381	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005381
GO_function	GO:0072345	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072345
GO_process	GO:0006812	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006812
GO_process	GO:0033572	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033572
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:0097352	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097352
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	MCOLN1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=MCOLN1
GeneID	57192	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57192
GeneTree	ENSGT00390000017126	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000017126
H-InvDB	HIX0023287	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0023287
HGNC	HGNC:13356	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13356
HOGENOM	HOG000232158	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000232158&db=HOGENOM6
HOVERGEN	HBG052430	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052430&db=HOVERGEN
HPA	CAB032637	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB032637
HPA	HPA031763	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031763
InParanoid	Q9GZU1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9GZU1
IntAct	Q9GZU1	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9GZU1*
InterPro	IPR013122	http://www.ebi.ac.uk/interpro/entry/IPR013122
Jabion	57192	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=57192
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00144	http://www.genome.jp/dbget-bin/www_bget?H00144
KEGG_Gene	hsa:57192	http://www.genome.jp/dbget-bin/www_bget?hsa:57192
KEGG_Orthology	KO:K04992	http://www.genome.jp/dbget-bin/www_bget?KO:K04992
KEGG_Pathway	ko04142	http://www.genome.jp/kegg-bin/show_pathway?ko04142
MIM	252650	http://www.ncbi.nlm.nih.gov/omim/252650
MIM	605248	http://www.ncbi.nlm.nih.gov/omim/605248
MINT	MINT-1409368	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1409368
OMA	PANDTFN	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PANDTFN
Orphanet	578	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=578
OrthoDB	EOG091G026A	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G026A
PSORT	swissprot:MCLN1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MCLN1_HUMAN
PSORT-B	swissprot:MCLN1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MCLN1_HUMAN
PSORT2	swissprot:MCLN1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MCLN1_HUMAN
Pfam	PF08016	http://pfam.xfam.org/family/PF08016
PharmGKB	PA30699	http://www.pharmgkb.org/do/serve?objId=PA30699&objCls=Gene
Phobius	swissprot:MCLN1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MCLN1_HUMAN
PhylomeDB	Q9GZU1	http://phylomedb.org/?seqid=Q9GZU1
ProteinModelPortal	Q9GZU1	http://www.proteinmodelportal.org/query/uniprot/Q9GZU1
PubMed	10973263	http://www.ncbi.nlm.nih.gov/pubmed/10973263
PubMed	11013137	http://www.ncbi.nlm.nih.gov/pubmed/11013137
PubMed	11030752	http://www.ncbi.nlm.nih.gov/pubmed/11030752
PubMed	11317355	http://www.ncbi.nlm.nih.gov/pubmed/11317355
PubMed	12182165	http://www.ncbi.nlm.nih.gov/pubmed/12182165
PubMed	12459486	http://www.ncbi.nlm.nih.gov/pubmed/12459486
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	14749347	http://www.ncbi.nlm.nih.gov/pubmed/14749347
PubMed	15178326	http://www.ncbi.nlm.nih.gov/pubmed/15178326
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15523648	http://www.ncbi.nlm.nih.gov/pubmed/15523648
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	17897319	http://www.ncbi.nlm.nih.gov/pubmed/17897319
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	19864416	http://www.ncbi.nlm.nih.gov/pubmed/19864416
Reactome	R-HSA-3295583	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3295583
Reactome	R-HSA-917977	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917977
RefSeq	NP_065394	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_065394
STRING	9606.ENSP00000264079	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000264079&targetmode=cogs
TCDB	1.A.5.3	http://www.tcdb.org/search/result.php?tc=1.A.5.3
UCSC	uc002mgo	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002mgo&org=rat
UniGene	Hs.631858	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.631858
UniProtKB	MCLN1_HUMAN	http://www.uniprot.org/uniprot/MCLN1_HUMAN
UniProtKB-AC	Q9GZU1	http://www.uniprot.org/uniprot/Q9GZU1
charge	swissprot:MCLN1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MCLN1_HUMAN
eggNOG	ENOG410Z1HH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z1HH
eggNOG	KOG3733	http://eggnogapi.embl.de/nog_data/html/tree/KOG3733
epestfind	swissprot:MCLN1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MCLN1_HUMAN
garnier	swissprot:MCLN1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MCLN1_HUMAN
helixturnhelix	swissprot:MCLN1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MCLN1_HUMAN
hmoment	swissprot:MCLN1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MCLN1_HUMAN
iep	swissprot:MCLN1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MCLN1_HUMAN
inforesidue	swissprot:MCLN1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MCLN1_HUMAN
neXtProt	NX_Q9GZU1	http://www.nextprot.org/db/entry/NX_Q9GZU1
octanol	swissprot:MCLN1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MCLN1_HUMAN
pepcoil	swissprot:MCLN1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MCLN1_HUMAN
pepdigest	swissprot:MCLN1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MCLN1_HUMAN
pepinfo	swissprot:MCLN1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MCLN1_HUMAN
pepnet	swissprot:MCLN1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MCLN1_HUMAN
pepstats	swissprot:MCLN1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MCLN1_HUMAN
pepwheel	swissprot:MCLN1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MCLN1_HUMAN
pepwindow	swissprot:MCLN1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MCLN1_HUMAN
sigcleave	swissprot:MCLN1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MCLN1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNK6_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y257-1; Sequence=Displayed; Name=2; IsoId=Q9Y257-2; Sequence=VSP_006692; 
# AltName	KCNK6_HUMAN	Inward rectifying potassium channel protein TWIK-2
# AltName	KCNK6_HUMAN	TWIK-originated similarity sequence
# CCDS	CCDS12513	-. [Q9Y257-1]
# ChiTaRS	KCNK6	human
# DrugBank	DB00308	Ibutilide
# DrugBank	DB00908	Quinidine
# Ensembl	ENST00000263372	ENSP00000263372; ENSG00000099337. [Q9Y257-1]
# ExpressionAtlas	Q9Y257	baseline and differential
# FUNCTION	KCNK6_HUMAN	Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008076	voltage-gated potassium channel complex; TAS:ProtInc.
# GO_function	GO:0005242	inward rectifier potassium channel activity; TAS:ProtInc.
# GO_function	GO:0005267	potassium channel activity; TAS:Reactome.
# GO_function	GO:0022841	potassium ion leak channel activity; IBA:GO_Central.
# GO_process	GO:0003085	negative regulation of systemic arterial blood pressure; IEA:Ensembl.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0030322	stabilization of membrane potential; IBA:GO_Central.
# GO_process	GO:0060075	regulation of resting membrane potential; IEA:Ensembl.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q9Y257	HS
# HGNC	HGNC:6281	KCNK6
# InterPro	IPR003092	2pore_dom_K_chnl_TASK
# InterPro	IPR003280	2pore_dom_K_chnl
# InterPro	IPR005408	2pore_dom_K_chnl_TWIK
# InterPro	IPR005409	2pore_dom_K_chnl_TWIK2
# InterPro	IPR013099	K_chnl_dom
# KEGG_Brite	ko04040	Ion channels
# MIM	603939	gene
# MISCELLANEOUS	KCNK6_HUMAN	Inhibited by internal acidification and, to a small degree, by zinc. Not inhibited by quinine, quinidine or barium. 
# Organism	KCNK6_HUMAN	Homo sapiens (Human)
# PIRSF	PIRSF038061	K_channel_subfamily_K_type
# PRINTS	PR01333	2POREKCHANEL
# PRINTS	PR01586	TWIKCHANNEL
# PRINTS	PR01587	TWIK2CHANNEL
# Pfam	PF07885	Ion_trans_2; 2
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-1299308	Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)
# Reactome	R-HSA-5576886	Phase 4 - resting membrane potential
# RecName	KCNK6_HUMAN	Potassium channel subfamily K member 6
# RefSeq	NP_004814	NM_004823.1. [Q9Y257-1]
# RefSeq	XP_011525828	XM_011527526.1. [Q9Y257-2]
# SIMILARITY	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCNK6_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUBUNIT	Homodimer. {ECO	0000305}. 
# TCDB	1.A.1.8	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	KCNK6_HUMAN	Widespread expression, detected in all tissues tested except for skeletal muscle. Strongest expression in placenta, pancreas, heart, colon and spleen, lower levels detected in peripheral blood leukocytes, lung, liver, kidney and thymus. Lowest expression detected in brain. 
# UCSC	uc002oic	human. [Q9Y257-1]
# eggNOG	COG1226	LUCA
# eggNOG	KOG1418	Eukaryota
BLAST	swissprot:KCNK6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNK6_HUMAN
BioCyc	ZFISH:ENSG00000099337-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000099337-MONOMER
COXPRESdb	9424	http://coxpresdb.jp/data/gene/9424.shtml
CleanEx	HS_KCNK6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNK6
DOI	10.1016/S0014-5793(99)00495-0	http://dx.doi.org/10.1016/S0014-5793(99)00495-0
DOI	10.1074/jbc.274.12.7887	http://dx.doi.org/10.1074/jbc.274.12.7887
DOI	10.1074/jbc.M003755200	http://dx.doi.org/10.1074/jbc.M003755200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00308	http://www.drugbank.ca/drugs/DB00308
DrugBank	DB00908	http://www.drugbank.ca/drugs/DB00908
EMBL	AF117708	http://www.ebi.ac.uk/ena/data/view/AF117708
EMBL	AF134149	http://www.ebi.ac.uk/ena/data/view/AF134149
EMBL	AF281302	http://www.ebi.ac.uk/ena/data/view/AF281302
EMBL	AF281303	http://www.ebi.ac.uk/ena/data/view/AF281303
EMBL	AJ297404	http://www.ebi.ac.uk/ena/data/view/AJ297404
EMBL	AJ297405	http://www.ebi.ac.uk/ena/data/view/AJ297405
EMBL	BC004367	http://www.ebi.ac.uk/ena/data/view/BC004367
Ensembl	ENST00000263372	http://www.ensembl.org/id/ENST00000263372
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_function	GO:0005242	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005242
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_function	GO:0022841	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022841
GO_process	GO:0003085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003085
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0030322	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030322
GO_process	GO:0060075	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060075
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	KCNK6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNK6
GeneID	9424	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9424
GeneTree	ENSGT00760000118858	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118858
H-InvDB	HIX0202814	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0202814
HGNC	HGNC:6281	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6281
HOGENOM	HOG000286014	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000286014&db=HOGENOM6
HOVERGEN	HBG052237	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052237&db=HOVERGEN
HPA	CAB022637	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB022637
HPA	HPA040184	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA040184
InParanoid	Q9Y257	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y257
InterPro	IPR003092	http://www.ebi.ac.uk/interpro/entry/IPR003092
InterPro	IPR003280	http://www.ebi.ac.uk/interpro/entry/IPR003280
InterPro	IPR005408	http://www.ebi.ac.uk/interpro/entry/IPR005408
InterPro	IPR005409	http://www.ebi.ac.uk/interpro/entry/IPR005409
InterPro	IPR013099	http://www.ebi.ac.uk/interpro/entry/IPR013099
Jabion	9424	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9424
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:9424	http://www.genome.jp/dbget-bin/www_bget?hsa:9424
KEGG_Orthology	KO:K04917	http://www.genome.jp/dbget-bin/www_bget?KO:K04917
MIM	603939	http://www.ncbi.nlm.nih.gov/omim/603939
OMA	PAVIFAH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PAVIFAH
OrthoDB	EOG091G0DIX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0DIX
PRINTS	PR01333	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01333
PRINTS	PR01586	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01586
PRINTS	PR01587	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01587
PSORT	swissprot:KCNK6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNK6_HUMAN
PSORT-B	swissprot:KCNK6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNK6_HUMAN
PSORT2	swissprot:KCNK6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNK6_HUMAN
Pfam	PF07885	http://pfam.xfam.org/family/PF07885
PharmGKB	PA30063	http://www.pharmgkb.org/do/serve?objId=PA30063&objCls=Gene
Phobius	swissprot:KCNK6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNK6_HUMAN
PhylomeDB	Q9Y257	http://phylomedb.org/?seqid=Q9Y257
ProteinModelPortal	Q9Y257	http://www.proteinmodelportal.org/query/uniprot/Q9Y257
PubMed	10075682	http://www.ncbi.nlm.nih.gov/pubmed/10075682
PubMed	10359073	http://www.ncbi.nlm.nih.gov/pubmed/10359073
PubMed	10887187	http://www.ncbi.nlm.nih.gov/pubmed/10887187
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-1299308	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1299308
Reactome	R-HSA-5576886	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576886
RefSeq	NP_004814	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004814
RefSeq	XP_011525828	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011525828
SMR	Q9Y257	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9Y257
STRING	9606.ENSP00000263372	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000263372&targetmode=cogs
TCDB	1.A.1.8	http://www.tcdb.org/search/result.php?tc=1.A.1.8
UCSC	uc002oic	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002oic&org=rat
UniGene	Hs.240395	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.240395
UniProtKB	KCNK6_HUMAN	http://www.uniprot.org/uniprot/KCNK6_HUMAN
UniProtKB-AC	Q9Y257	http://www.uniprot.org/uniprot/Q9Y257
charge	swissprot:KCNK6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNK6_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG1418	http://eggnogapi.embl.de/nog_data/html/tree/KOG1418
epestfind	swissprot:KCNK6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNK6_HUMAN
garnier	swissprot:KCNK6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNK6_HUMAN
helixturnhelix	swissprot:KCNK6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNK6_HUMAN
hmoment	swissprot:KCNK6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNK6_HUMAN
iep	swissprot:KCNK6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNK6_HUMAN
inforesidue	swissprot:KCNK6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNK6_HUMAN
neXtProt	NX_Q9Y257	http://www.nextprot.org/db/entry/NX_Q9Y257
octanol	swissprot:KCNK6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNK6_HUMAN
pepcoil	swissprot:KCNK6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNK6_HUMAN
pepdigest	swissprot:KCNK6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNK6_HUMAN
pepinfo	swissprot:KCNK6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNK6_HUMAN
pepnet	swissprot:KCNK6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNK6_HUMAN
pepstats	swissprot:KCNK6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNK6_HUMAN
pepwheel	swissprot:KCNK6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNK6_HUMAN
pepwindow	swissprot:KCNK6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNK6_HUMAN
sigcleave	swissprot:KCNK6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNK6_HUMAN
## Database	ID	URL or Descriptions
# AltName	CCG3_HUMAN	Neuronal voltage-gated calcium channel gamma-3 subunit
# AltName	CCG3_HUMAN	Transmembrane AMPAR regulatory protein gamma-3
# BioGrid	115647	3
# Ensembl	ENST00000005284	ENSP00000005284; ENSG00000006116
# FUNCTION	CCG3_HUMAN	Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity). {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005891	voltage-gated calcium channel complex; NAS:UniProtKB.
# GO_component	GO:0030666	endocytic vesicle membrane; TAS:Reactome.
# GO_component	GO:0032281	AMPA glutamate receptor complex; ISS:UniProtKB.
# GO_function	GO:0005245	voltage-gated calcium channel activity; NAS:UniProtKB.
# GO_function	GO:0016247	channel regulator activity; IBA:GO_Central.
# GO_process	GO:0006816	calcium ion transport; NAS:UniProtKB.
# GO_process	GO:0019226	transmission of nerve impulse; IBA:GO_Central.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:0070588	calcium ion transmembrane transport; IBA:GO_Central.
# GO_process	GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	O60359	HS
# HGNC	HGNC:1407	CACNG3
# InterPro	IPR004031	PMP22/EMP/MP20/Claudin
# InterPro	IPR008368	VDCC_gsu
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04010	MAPK signaling pathway
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05410	Hypertrophic cardiomyopathy (HCM)
# KEGG_Pathway	ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
# KEGG_Pathway	ko05414	Dilated cardiomyopathy
# MIM	606403	gene
# Organism	CCG3_HUMAN	Homo sapiens (Human)
# PRINTS	PR01792	VDCCGAMMA
# Pfam	PF00822	PMP22_Claudin
# Proteomes	UP000005640	Chromosome 16
# Reactome	R-HSA-399719	Trafficking of AMPA receptors
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# Reactome	R-HSA-5576893	Phase 2 - plateau phase
# Reactome	R-HSA-5576894	Phase 1 - inactivation of fast Na+ channels
# Reactome	R-HSA-5682910	LGI-ADAM interactions
# RecName	CCG3_HUMAN	Voltage-dependent calcium channel gamma-3 subunit
# RefSeq	NP_006530	NM_006539.3
# SIMILARITY	Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	CCG3_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG4, CACNG5, CACNG7 and CACNG8 (By similarity). {ECO	0000250}. 
# TCDB	8.A.16.2	the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family
# UCSC	uc002dmf	human
# eggNOG	ENOG410IFNQ	Eukaryota
# eggNOG	ENOG4110ISU	LUCA
BLAST	swissprot:CCG3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CCG3_HUMAN
BioCyc	ZFISH:ENSG00000006116-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000006116-MONOMER
COXPRESdb	10368	http://coxpresdb.jp/data/gene/10368.shtml
CleanEx	HS_CACNG3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CACNG3
DOI	10.1006/geno.1999.5927	http://dx.doi.org/10.1006/geno.1999.5927
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.4065/74.4.357	http://dx.doi.org/10.4065/74.4.357
EMBL	AC004125	http://www.ebi.ac.uk/ena/data/view/AC004125
EMBL	AF100346	http://www.ebi.ac.uk/ena/data/view/AF100346
EMBL	AF114832	http://www.ebi.ac.uk/ena/data/view/AF114832
EMBL	AF134640	http://www.ebi.ac.uk/ena/data/view/AF134640
EMBL	BC037899	http://www.ebi.ac.uk/ena/data/view/BC037899
EMBL	BC040005	http://www.ebi.ac.uk/ena/data/view/BC040005
Ensembl	ENST00000005284	http://www.ensembl.org/id/ENST00000005284
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005891
GO_component	GO:0030666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030666
GO_component	GO:0032281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032281
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0016247	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016247
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0019226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019226
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:2000311	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000311
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	CACNG3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CACNG3
GeneID	10368	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10368
GeneTree	ENSGT00550000074547	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074547
HGNC	HGNC:1407	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1407
HOGENOM	HOG000233440	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233440&db=HOGENOM6
HOVERGEN	HBG003682	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003682&db=HOVERGEN
HPA	HPA059010	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA059010
InParanoid	O60359	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O60359
InterPro	IPR004031	http://www.ebi.ac.uk/interpro/entry/IPR004031
InterPro	IPR008368	http://www.ebi.ac.uk/interpro/entry/IPR008368
Jabion	10368	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10368
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:10368	http://www.genome.jp/dbget-bin/www_bget?hsa:10368
KEGG_Orthology	KO:K04868	http://www.genome.jp/dbget-bin/www_bget?KO:K04868
KEGG_Pathway	ko04010	http://www.genome.jp/kegg-bin/show_pathway?ko04010
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05410	http://www.genome.jp/kegg-bin/show_pathway?ko05410
KEGG_Pathway	ko05412	http://www.genome.jp/kegg-bin/show_pathway?ko05412
KEGG_Pathway	ko05414	http://www.genome.jp/kegg-bin/show_pathway?ko05414
MIM	606403	http://www.ncbi.nlm.nih.gov/omim/606403
OMA	LNSERDH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LNSERDH
OrthoDB	EOG091G0D2Z	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0D2Z
PRINTS	PR01792	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01792
PSORT	swissprot:CCG3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CCG3_HUMAN
PSORT-B	swissprot:CCG3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CCG3_HUMAN
PSORT2	swissprot:CCG3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CCG3_HUMAN
Pfam	PF00822	http://pfam.xfam.org/family/PF00822
PharmGKB	PA26017	http://www.pharmgkb.org/do/serve?objId=PA26017&objCls=Gene
Phobius	swissprot:CCG3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CCG3_HUMAN
PhylomeDB	O60359	http://phylomedb.org/?seqid=O60359
ProteinModelPortal	O60359	http://www.proteinmodelportal.org/query/uniprot/O60359
PubMed	10221464	http://www.ncbi.nlm.nih.gov/pubmed/10221464
PubMed	10493829	http://www.ncbi.nlm.nih.gov/pubmed/10493829
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-399719	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-399719
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
Reactome	R-HSA-5576893	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576893
Reactome	R-HSA-5576894	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576894
Reactome	R-HSA-5682910	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5682910
RefSeq	NP_006530	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006530
STRING	9606.ENSP00000005284	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000005284&targetmode=cogs
TCDB	8.A.16.2	http://www.tcdb.org/search/result.php?tc=8.A.16.2
UCSC	uc002dmf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002dmf&org=rat
UniGene	Hs.7235	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.7235
UniProtKB	CCG3_HUMAN	http://www.uniprot.org/uniprot/CCG3_HUMAN
UniProtKB-AC	O60359	http://www.uniprot.org/uniprot/O60359
charge	swissprot:CCG3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CCG3_HUMAN
eggNOG	ENOG410IFNQ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IFNQ
eggNOG	ENOG4110ISU	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110ISU
epestfind	swissprot:CCG3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CCG3_HUMAN
garnier	swissprot:CCG3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CCG3_HUMAN
helixturnhelix	swissprot:CCG3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CCG3_HUMAN
hmoment	swissprot:CCG3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CCG3_HUMAN
iep	swissprot:CCG3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CCG3_HUMAN
inforesidue	swissprot:CCG3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CCG3_HUMAN
neXtProt	NX_O60359	http://www.nextprot.org/db/entry/NX_O60359
octanol	swissprot:CCG3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CCG3_HUMAN
pepcoil	swissprot:CCG3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CCG3_HUMAN
pepdigest	swissprot:CCG3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CCG3_HUMAN
pepinfo	swissprot:CCG3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CCG3_HUMAN
pepnet	swissprot:CCG3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CCG3_HUMAN
pepstats	swissprot:CCG3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CCG3_HUMAN
pepwheel	swissprot:CCG3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CCG3_HUMAN
pepwindow	swissprot:CCG3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CCG3_HUMAN
sigcleave	swissprot:CCG3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CCG3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=CAT-2B; IsoId=P52569-1; Sequence=Displayed; Name=2; Synonyms=CAT-2A; IsoId=P52569-2; Sequence=VSP_037354, VSP_023354; Note=Ref.2 (AAB62810) sequence differs from that shown due to a frameshift in position 29. {ECO	0000305}; Name=3; IsoId=P52569-3; Sequence=VSP_037354; Note=No experimental confirmation available.; 
# AltName	CTR2_HUMAN	Low affinity cationic amino acid transporter 2
# AltName	CTR2_HUMAN	Solute carrier family 7 member 2
# BioGrid	112433	23
# CCDS	CCDS34852	-. [P52569-1]
# CCDS	CCDS55203	-. [P52569-3]
# CCDS	CCDS6002	-. [P52569-2]
# ChiTaRS	SLC7A2	human
# DrugBank	DB00123	L-Lysine
# DrugBank	DB00129	L-Ornithine
# Ensembl	ENST00000004531	ENSP00000004531; ENSG00000003989. [P52569-3]
# Ensembl	ENST00000398090	ENSP00000381164; ENSG00000003989. [P52569-2]
# Ensembl	ENST00000470360	ENSP00000419873; ENSG00000003989. [P52569-2]
# Ensembl	ENST00000494857	ENSP00000419140; ENSG00000003989. [P52569-1]
# Ensembl	ENST00000522656	ENSP00000430464; ENSG00000003989. [P52569-1]
# FUNCTION	CTR2_HUMAN	Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) (PubMed 9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport. {ECO 0000250|UniProtKB P18581, ECO 0000269|PubMed 9174363}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_function	GO:0005289	high-affinity arginine transmembrane transporter activity; IEA:Ensembl.
# GO_function	GO:0005292	high-affinity lysine transmembrane transporter activity; IEA:Ensembl.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015174	basic amino acid transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0015179	L-amino acid transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015297	antiporter activity; IBA:GO_Central.
# GO_function	GO:0097626	low-affinity L-arginine transmembrane transporter activity; IEA:Ensembl.
# GO_function	GO:0097627	high-affinity L-ornithine transmembrane transporter activity; IEA:Ensembl.
# GO_process	GO:0002537	nitric oxide production involved in inflammatory response; IEA:Ensembl.
# GO_process	GO:0006520	cellular amino acid metabolic process; TAS:ProtInc.
# GO_process	GO:0006809	nitric oxide biosynthetic process; IEA:Ensembl.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006865	amino acid transport; TAS:Reactome.
# GO_process	GO:0015809	arginine transport; IEA:Ensembl.
# GO_process	GO:0042116	macrophage activation; IEA:Ensembl.
# GO_process	GO:0043030	regulation of macrophage activation; IEA:Ensembl.
# GO_process	GO:0050727	regulation of inflammatory response; IEA:Ensembl.
# GO_process	GO:0097638	L-arginine import across plasma membrane; IEA:Ensembl.
# GO_process	GO:0097639	L-lysine import across plasma membrane; IEA:Ensembl.
# GO_process	GO:0097640	L-ornithine import across plasma membrane; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006520	cellular amino acid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P52569	HS
# HGNC	HGNC:11060	SLC7A2
# IntAct	P52569	2
# InterPro	IPR002293	AA/rel_permease1
# InterPro	IPR004755	Cat_AA_permease
# InterPro	IPR029485	CAT_C
# KEGG_Brite	ko02001	Solute carrier family
# MIM	601872	gene
# Organism	CTR2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11785	PTHR11785; 3
# Pfam	PF13520	AA_permease_2
# Pfam	PF13906	AA_permease_C
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-352230	Amino acid transport across the plasma membrane
# RecName	CTR2_HUMAN	Cationic amino acid transporter 2
# RefSeq	NP_001008539	NM_001008539.3. [P52569-1]
# RefSeq	NP_001158243	NM_001164771.1. [P52569-3]
# RefSeq	NP_003037	NM_003046.5. [P52569-2]
# RefSeq	XP_005273667	XM_005273610.4. [P52569-1]
# RefSeq	XP_005273668	XM_005273611.4. [P52569-1]
# RefSeq	XP_005273669	XM_005273612.4. [P52569-1]
# RefSeq	XP_016869235	XM_017013746.1. [P52569-1]
# RefSeq	XP_016869236	XM_017013747.1
# SEQUENCE CAUTION	CTR2_HUMAN	Sequence=AAH69648.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=AAI04906.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=AAI13662.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=AAI43584.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305};
# SIMILARITY	Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	CTR2_HUMAN	Cell membrane {ECO 0000269|PubMed 9174363}; Multi-pass membrane protein {ECO 0000269|PubMed 9174363}. 
# TCDB	2.A.3.3	the amino acid-polyamine-organocation (apc) family
# TIGRFAMs	TIGR00906	2A0303
# TISSUE SPECIFICITY	Expressed at high levels in the skeletal muscle, placenta and ovary. Expressed at intermediate levels in the liver and pancreas and at low levels in the kidney and heart. {ECO:0000269|PubMed	8954799}. 
# UCSC	uc011kyc	human. [P52569-1]
# eggNOG	COG0531	LUCA
# eggNOG	KOG1286	Eukaryota
BLAST	swissprot:CTR2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CTR2_HUMAN
BioCyc	ZFISH:ENSG00000003989-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000003989-MONOMER
COXPRESdb	6542	http://coxpresdb.jp/data/gene/6542.shtml
CleanEx	HS_SLC7A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC7A2
DOI	10.1006/geno.1996.0613	http://dx.doi.org/10.1006/geno.1996.0613
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/bi962829p	http://dx.doi.org/10.1021/bi962829p
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04406	http://dx.doi.org/10.1038/nature04406
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DrugBank	DB00123	http://www.drugbank.ca/drugs/DB00123
DrugBank	DB00129	http://www.drugbank.ca/drugs/DB00129
EMBL	AB020863	http://www.ebi.ac.uk/ena/data/view/AB020863
EMBL	AL832016	http://www.ebi.ac.uk/ena/data/view/AL832016
EMBL	BC069648	http://www.ebi.ac.uk/ena/data/view/BC069648
EMBL	BC104905	http://www.ebi.ac.uk/ena/data/view/BC104905
EMBL	BC113661	http://www.ebi.ac.uk/ena/data/view/BC113661
EMBL	BC143583	http://www.ebi.ac.uk/ena/data/view/BC143583
EMBL	CH471080	http://www.ebi.ac.uk/ena/data/view/CH471080
EMBL	D29990	http://www.ebi.ac.uk/ena/data/view/D29990
EMBL	U76368	http://www.ebi.ac.uk/ena/data/view/U76368
EMBL	U76369	http://www.ebi.ac.uk/ena/data/view/U76369
Ensembl	ENST00000004531	http://www.ensembl.org/id/ENST00000004531
Ensembl	ENST00000398090	http://www.ensembl.org/id/ENST00000398090
Ensembl	ENST00000470360	http://www.ensembl.org/id/ENST00000470360
Ensembl	ENST00000494857	http://www.ensembl.org/id/ENST00000494857
Ensembl	ENST00000522656	http://www.ensembl.org/id/ENST00000522656
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0005289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005289
GO_function	GO:0005292	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005292
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_function	GO:0015174	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015174
GO_function	GO:0015179	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015179
GO_function	GO:0015297	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297
GO_function	GO:0097626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097626
GO_function	GO:0097627	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097627
GO_process	GO:0002537	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002537
GO_process	GO:0006520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520
GO_process	GO:0006809	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006809
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GO_process	GO:0015809	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015809
GO_process	GO:0042116	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042116
GO_process	GO:0043030	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043030
GO_process	GO:0050727	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050727
GO_process	GO:0097638	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097638
GO_process	GO:0097639	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097639
GO_process	GO:0097640	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097640
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC7A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC7A2
GeneID	6542	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6542
GeneTree	ENSGT00760000119151	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119151
HGNC	HGNC:11060	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11060
HOGENOM	HOG000250623	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000250623&db=HOGENOM6
HOVERGEN	HBG000280	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000280&db=HOVERGEN
HPA	CAB020842	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB020842
InParanoid	P52569	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52569
IntAct	P52569	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52569*
InterPro	IPR002293	http://www.ebi.ac.uk/interpro/entry/IPR002293
InterPro	IPR004755	http://www.ebi.ac.uk/interpro/entry/IPR004755
InterPro	IPR029485	http://www.ebi.ac.uk/interpro/entry/IPR029485
Jabion	6542	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6542
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6542	http://www.genome.jp/dbget-bin/www_bget?hsa:6542
KEGG_Orthology	KO:K13864	http://www.genome.jp/dbget-bin/www_bget?KO:K13864
MIM	601872	http://www.ncbi.nlm.nih.gov/omim/601872
OMA	AVIAKYW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AVIAKYW
OrthoDB	EOG091G05NM	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05NM
PANTHER	PTHR11785	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785
PSORT	swissprot:CTR2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CTR2_HUMAN
PSORT-B	swissprot:CTR2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CTR2_HUMAN
PSORT2	swissprot:CTR2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CTR2_HUMAN
Pfam	PF13520	http://pfam.xfam.org/family/PF13520
Pfam	PF13906	http://pfam.xfam.org/family/PF13906
PharmGKB	PA35920	http://www.pharmgkb.org/do/serve?objId=PA35920&objCls=Gene
Phobius	swissprot:CTR2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CTR2_HUMAN
PhylomeDB	P52569	http://phylomedb.org/?seqid=P52569
ProteinModelPortal	P52569	http://www.proteinmodelportal.org/query/uniprot/P52569
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16421571	http://www.ncbi.nlm.nih.gov/pubmed/16421571
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	8954799	http://www.ncbi.nlm.nih.gov/pubmed/8954799
PubMed	9174363	http://www.ncbi.nlm.nih.gov/pubmed/9174363
Reactome	R-HSA-352230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-352230
RefSeq	NP_001008539	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001008539
RefSeq	NP_001158243	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001158243
RefSeq	NP_003037	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003037
RefSeq	XP_005273667	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005273667
RefSeq	XP_005273668	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005273668
RefSeq	XP_005273669	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005273669
RefSeq	XP_016869235	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016869235
RefSeq	XP_016869236	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016869236
STRING	9606.ENSP00000004531	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000004531&targetmode=cogs
TCDB	2.A.3.3	http://www.tcdb.org/search/result.php?tc=2.A.3.3
TIGRFAMs	TIGR00906	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00906
UCSC	uc011kyc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc011kyc&org=rat
UniGene	Hs.448520	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.448520
UniProtKB	CTR2_HUMAN	http://www.uniprot.org/uniprot/CTR2_HUMAN
UniProtKB-AC	P52569	http://www.uniprot.org/uniprot/P52569
charge	swissprot:CTR2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CTR2_HUMAN
eggNOG	COG0531	http://eggnogapi.embl.de/nog_data/html/tree/COG0531
eggNOG	KOG1286	http://eggnogapi.embl.de/nog_data/html/tree/KOG1286
epestfind	swissprot:CTR2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CTR2_HUMAN
garnier	swissprot:CTR2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CTR2_HUMAN
helixturnhelix	swissprot:CTR2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CTR2_HUMAN
hmoment	swissprot:CTR2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CTR2_HUMAN
iep	swissprot:CTR2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CTR2_HUMAN
inforesidue	swissprot:CTR2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CTR2_HUMAN
neXtProt	NX_P52569	http://www.nextprot.org/db/entry/NX_P52569
octanol	swissprot:CTR2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CTR2_HUMAN
pepcoil	swissprot:CTR2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CTR2_HUMAN
pepdigest	swissprot:CTR2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CTR2_HUMAN
pepinfo	swissprot:CTR2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CTR2_HUMAN
pepnet	swissprot:CTR2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CTR2_HUMAN
pepstats	swissprot:CTR2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CTR2_HUMAN
pepwheel	swissprot:CTR2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CTR2_HUMAN
pepwindow	swissprot:CTR2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CTR2_HUMAN
sigcleave	swissprot:CTR2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CTR2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCAB2_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=KvB2.1; IsoId=Q13303-1; Sequence=Displayed; Name=2; Synonyms=KvB2.2; IsoId=Q13303-2; Sequence=VSP_001054; Name=3; IsoId=Q13303-3; Sequence=VSP_041189, VSP_041190; Name=4; IsoId=Q13303-4; Sequence=VSP_044311; Name=5; IsoId=Q13303-5; Sequence=VSP_057282; Note=No experimental confirmation available.; 
# AltName	KCAB2_HUMAN	K(+) channel subunit beta-2
# AltName	KCAB2_HUMAN	Kv-beta-2
# BioGrid	114086	36
# CCDS	CCDS55	-. [Q13303-1]
# CCDS	CCDS55570	-. [Q13303-3]
# CCDS	CCDS55571	-. [Q13303-4]
# CCDS	CCDS56	-. [Q13303-2]
# CDD	cd06660	Aldo_ket_red
# ChiTaRS	KCNAB2	human
# DOMAIN	KCAB2_HUMAN	In contrast to KCNAB1, the shorter N-terminal domain of KCNAB2 cannot mediate closure of delayed rectifier potassium channels by physically obstructing the pore. {ECO 0000269|PubMed 7649300}. 
# Ensembl	ENST00000164247	ENSP00000164247; ENSG00000069424. [Q13303-1]
# Ensembl	ENST00000341524	ENSP00000340824; ENSG00000069424. [Q13303-1]
# Ensembl	ENST00000352527	ENSP00000318772; ENSG00000069424. [Q13303-2]
# Ensembl	ENST00000378083	ENSP00000367323; ENSG00000069424. [Q13303-3]
# Ensembl	ENST00000378092	ENSP00000367332; ENSG00000069424. [Q13303-2]
# Ensembl	ENST00000378097	ENSP00000367337; ENSG00000069424. [Q13303-1]
# Ensembl	ENST00000458166	ENSP00000396167; ENSG00000069424. [Q13303-4]
# Ensembl	ENST00000602612	ENSP00000473602; ENSG00000069424. [Q13303-5]
# ExpressionAtlas	Q13303	baseline and differential
# FUNCTION	KCAB2_HUMAN	Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed 7649300, PubMed 11825900). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed 7649300, PubMed 11825900). Promotes KCNA4 channel closure (PubMed 7649300, PubMed 11825900). Modulates the functional properties of KCNA5 (By similarity). Enhances KCNB2 channel activity (By similarity). Binds NADPH and has NADPH- dependent aldoketoreductase activity (By similarity). Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4- nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (By similarity). {ECO 0000250|UniProtKB P62482, ECO 0000250|UniProtKB P62483, ECO 0000269|PubMed 11825900, ECO 0000269|PubMed 7649300}. 
# GO_component	GO:0005829	cytosol; ISS:UniProtKB.
# GO_component	GO:0005856	cytoskeleton; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IDA:UniProtKB.
# GO_component	GO:0014069	postsynaptic density; IEA:Ensembl.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane; ISS:UniProtKB.
# GO_component	GO:0043679	axon terminus; IEA:Ensembl.
# GO_component	GO:0044224	juxtaparanode region of axon; IDA:UniProtKB.
# GO_component	GO:1990031	pinceau fiber; ISS:UniProtKB.
# GO_function	GO:0004033	aldo-keto reductase (NADP) activity; ISS:UniProtKB.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IEA:InterPro.
# GO_function	GO:0015459	potassium channel regulator activity; IDA:UniProtKB.
# GO_process	GO:0002244	hematopoietic progenitor cell differentiation; IEA:Ensembl.
# GO_process	GO:0050905	neuromuscular process; IEA:Ensembl.
# GO_process	GO:0055114	oxidation-reduction process; ISS:UniProtKB.
# GO_process	GO:0070995	NADPH oxidation; ISS:UniProtKB.
# GO_process	GO:1901379	regulation of potassium ion transmembrane transport; IDA:UniProtKB.
# GO_process	GO:2000008	regulation of protein localization to cell surface; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005856	cytoskeleton
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0051186	cofactor metabolic process
# Gene3D	3.20.20.100	-; 1.
# Genevisible	Q13303	HS
# HGNC	HGNC:6229	KCNAB2
# IntAct	Q13303	13
# InterPro	IPR001395	Aldo/ket_red/Kv-b
# InterPro	IPR005399	K_chnl_volt-dep_bsu_KCNAB-rel
# InterPro	IPR005401	K_chnl_volt-dep_bsu_KCNAB2
# InterPro	IPR005983	K_chnl_volt-dep_bsu_KCNAB
# InterPro	IPR023210	NADP_OxRdtase_dom
# KEGG_Brite	ko04040	Ion channels
# MIM	601142	gene
# Organism	KCAB2_HUMAN	Homo sapiens (Human)
# Orphanet	1606	1p36 deletion syndrome
# PANTHER	PTHR11732	PTHR11732
# PDB	1ZSX	X-ray; 1.90 A; A=39-360
# PIR	S66502	S66502
# PRINTS	PR01577	KCNABCHANNEL
# PRINTS	PR01579	KCNAB2CHANEL
# PTM	KCAB2_HUMAN	Phosphorylated by PRKCZ; may be regulated by incorporation in a complex composed of PRKCZ and SQSTM1. {ECO 0000250|UniProtKB P62483}. 
# Pfam	PF00248	Aldo_ket_red
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# Reactome	R-HSA-6798695	Neutrophil degranulation
# RecName	KCAB2_HUMAN	Voltage-gated potassium channel subunit beta-2
# RefSeq	NP_001186789	NM_001199860.1. [Q13303-1]
# RefSeq	NP_001186790	NM_001199861.1. [Q13303-1]
# RefSeq	NP_001186791	NM_001199862.1. [Q13303-3]
# RefSeq	NP_001186792	NM_001199863.1. [Q13303-4]
# RefSeq	NP_003627	NM_003636.3. [Q13303-1]
# RefSeq	NP_742128	NM_172130.2. [Q13303-2]
# RefSeq	XP_005263571	XM_005263514.2. [Q13303-2]
# RefSeq	XP_011540623	XM_011542321.2. [Q13303-5]
# RefSeq	XP_011540624	XM_011542322.2. [Q13303-5]
# SIMILARITY	Belongs to the shaker potassium channel beta subunit family. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCAB2_HUMAN	Cytoplasm {ECO 0000250|UniProtKB P62483}. Membrane {ECO 0000269|PubMed 11086297, ECO 0000269|PubMed 21357749}; Peripheral membrane protein {ECO 0000305}; Cytoplasmic side {ECO 0000305}. Cell membrane {ECO 0000250|UniProtKB P62483}; Peripheral membrane protein {ECO 0000305}; Cytoplasmic side {ECO 0000305}. Cell projection, axon {ECO 0000269|PubMed 11086297}. Cell junction, synapse, synaptosome {ECO 0000269|PubMed 21357749}. Cytoplasm, cytoskeleton {ECO 0000250|UniProtKB P62483}. Note=Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits. Associates with microtubules when unphosphorylated. {ECO 0000250|UniProtKB P62483}. 
# SUBUNIT	KCAB2_HUMAN	Homotetramer (By similarity). Interaction with tetrameric potassium channel alpha subunits gives rise to a heterooctamer (By similarity). Identified in potassium channel complexes containing KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNAB1 and KCNAB2 (By similarity). Interacts with KCNA1 (PubMed 11086297). Interacts with KCNA2 (PubMed 11086297). Interacts with KCNA4 and KCND3 (By similarity). Interacts with KCNA5 (By similarity). Interacts with KCNB2 (By similarity). Interacts (in unphosphorylated form) with MAPRE1 (By similarity). Forms a ternary complex with SQSTM1 and PRKCZ (By similarity). {ECO 0000250|UniProtKB P62482, ECO 0000250|UniProtKB P62483, ECO 0000269|PubMed 11086297}. 
# SUPFAM	SSF51430	SSF51430
# TIGRFAMs	TIGR01293	Kv_beta
# TISSUE SPECIFICITY	KCAB2_HUMAN	Detected in myelinated nerve fibers in the spinal cord, in the juxtaparanodal region of the nodes of Ranvier, but also in the paranodal region (PubMed 11086297). Detected in hippocampus (at protein level) (PubMed 21357749). Detected in hippocampus (PubMed 7649300). {ECO 0000269|PubMed 11086297, ECO 0000269|PubMed 21357749, ECO 0000269|PubMed 7649300}. 
# UCSC	uc001alv	human. [Q13303-1]
# eggNOG	COG0667	LUCA
# eggNOG	KOG1575	Eukaryota
BLAST	swissprot:KCAB2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCAB2_HUMAN
BioCyc	ZFISH:ENSG00000069424-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000069424-MONOMER
COXPRESdb	8514	http://coxpresdb.jp/data/gene/8514.shtml
CleanEx	HS_KCNAB2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNAB2
CleanEx	HS_KCNK2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNK2
DOI	10.1002/1096-9861(20000101)429:1<166::AID-CNE13>3.0.CO	http://dx.doi.org/10.1002/1096-9861(20000101)429:1<166::AID-CNE13>3.0.CO
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/0014-5793(95)00785-8	http://dx.doi.org/10.1016/0014-5793(95)00785-8
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1074/jbc.M111465200	http://dx.doi.org/10.1074/jbc.M111465200
DOI	10.1074/mcp.O113.027870	http://dx.doi.org/10.1074/mcp.O113.027870
DOI	10.1083/jcb.201007113	http://dx.doi.org/10.1083/jcb.201007113
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EC_number	EC:1.1.1.- {ECO:0000250|UniProtKB:P62483}	http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.- {ECO:0000250|UniProtKB:P62483}
EMBL	AF029749	http://www.ebi.ac.uk/ena/data/view/AF029749
EMBL	AF044253	http://www.ebi.ac.uk/ena/data/view/AF044253
EMBL	AK124696	http://www.ebi.ac.uk/ena/data/view/AK124696
EMBL	AK131252	http://www.ebi.ac.uk/ena/data/view/AK131252
EMBL	AK289819	http://www.ebi.ac.uk/ena/data/view/AK289819
EMBL	AK315858	http://www.ebi.ac.uk/ena/data/view/AK315858
EMBL	AL035406	http://www.ebi.ac.uk/ena/data/view/AL035406
EMBL	AL035406	http://www.ebi.ac.uk/ena/data/view/AL035406
EMBL	BC110351	http://www.ebi.ac.uk/ena/data/view/BC110351
EMBL	BC126424	http://www.ebi.ac.uk/ena/data/view/BC126424
EMBL	BC130413	http://www.ebi.ac.uk/ena/data/view/BC130413
EMBL	U33429	http://www.ebi.ac.uk/ena/data/view/U33429
ENZYME	1.1.1.- {ECO:0000250|UniProtKB:P62483}	http://enzyme.expasy.org/EC/1.1.1.- {ECO:0000250|UniProtKB:P62483}
Ensembl	ENST00000164247	http://www.ensembl.org/id/ENST00000164247
Ensembl	ENST00000341524	http://www.ensembl.org/id/ENST00000341524
Ensembl	ENST00000352527	http://www.ensembl.org/id/ENST00000352527
Ensembl	ENST00000378083	http://www.ensembl.org/id/ENST00000378083
Ensembl	ENST00000378092	http://www.ensembl.org/id/ENST00000378092
Ensembl	ENST00000378097	http://www.ensembl.org/id/ENST00000378097
Ensembl	ENST00000458166	http://www.ensembl.org/id/ENST00000458166
Ensembl	ENST00000602612	http://www.ensembl.org/id/ENST00000602612
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0014069	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014069
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0031234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031234
GO_component	GO:0043679	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043679
GO_component	GO:0044224	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044224
GO_component	GO:1990031	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990031
GO_function	GO:0004033	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004033
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0015459	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015459
GO_process	GO:0002244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002244
GO_process	GO:0050905	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050905
GO_process	GO:0055114	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114
GO_process	GO:0070995	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070995
GO_process	GO:1901379	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901379
GO_process	GO:2000008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000008
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0051186	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186
Gene3D	3.20.20.100	http://www.cathdb.info/version/latest/superfamily/3.20.20.100
GeneCards	KCNAB2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNAB2
GeneID	8514	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8514
GeneTree	ENSGT00550000074567	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074567
HGNC	HGNC:6229	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6229
HOGENOM	HOG000250283	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000250283&db=HOGENOM6
HOVERGEN	HBG052216	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052216&db=HOVERGEN
HPA	CAB001975	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB001975
HPA	HPA030185	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA030185
InParanoid	Q13303	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q13303
IntAct	Q13303	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q13303*
IntEnz	1.1.1.- {ECO:0000250|UniProtKB:P62483}	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.- {ECO:0000250|UniProtKB:P62483}
InterPro	IPR001395	http://www.ebi.ac.uk/interpro/entry/IPR001395
InterPro	IPR005399	http://www.ebi.ac.uk/interpro/entry/IPR005399
InterPro	IPR005401	http://www.ebi.ac.uk/interpro/entry/IPR005401
InterPro	IPR005983	http://www.ebi.ac.uk/interpro/entry/IPR005983
InterPro	IPR023210	http://www.ebi.ac.uk/interpro/entry/IPR023210
Jabion	8514	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=8514
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:8514	http://www.genome.jp/dbget-bin/www_bget?hsa:8514
KEGG_Orthology	KO:K04883	http://www.genome.jp/dbget-bin/www_bget?KO:K04883
MIM	601142	http://www.ncbi.nlm.nih.gov/omim/601142
MINT	MINT-2865320	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-2865320
OMA	CINNLEF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CINNLEF
Orphanet	1606	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1606
OrthoDB	EOG091G0KDN	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0KDN
PANTHER	PTHR11732	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11732
PDB	1ZSX	http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZSX
PDBsum	1ZSX	http://www.ebi.ac.uk/pdbsum/1ZSX
PRINTS	PR01577	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01577
PRINTS	PR01579	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01579
PSORT	swissprot:KCAB2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCAB2_HUMAN
PSORT-B	swissprot:KCAB2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCAB2_HUMAN
PSORT2	swissprot:KCAB2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCAB2_HUMAN
Pfam	PF00248	http://pfam.xfam.org/family/PF00248
PharmGKB	PA373	http://www.pharmgkb.org/do/serve?objId=PA373&objCls=Gene
Phobius	swissprot:KCAB2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCAB2_HUMAN
PhylomeDB	Q13303	http://phylomedb.org/?seqid=Q13303
ProteinModelPortal	Q13303	http://www.proteinmodelportal.org/query/uniprot/Q13303
PubMed	11086297	http://www.ncbi.nlm.nih.gov/pubmed/11086297
PubMed	11825900	http://www.ncbi.nlm.nih.gov/pubmed/11825900
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21357749	http://www.ncbi.nlm.nih.gov/pubmed/21357749
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24129315	http://www.ncbi.nlm.nih.gov/pubmed/24129315
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	7649300	http://www.ncbi.nlm.nih.gov/pubmed/7649300
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
Reactome	R-HSA-6798695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6798695
RefSeq	NP_001186789	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001186789
RefSeq	NP_001186790	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001186790
RefSeq	NP_001186791	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001186791
RefSeq	NP_001186792	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001186792
RefSeq	NP_003627	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003627
RefSeq	NP_742128	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_742128
RefSeq	XP_005263571	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005263571
RefSeq	XP_011540623	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011540623
RefSeq	XP_011540624	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011540624
SMR	Q13303	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q13303
STRING	9606.ENSP00000367323	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000367323&targetmode=cogs
SUPFAM	SSF51430	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51430
TIGRFAMs	TIGR01293	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01293
UCSC	uc001alv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001alv&org=rat
UniGene	Hs.440497	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.440497
UniGene	Hs.735032	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.735032
UniProtKB	KCAB2_HUMAN	http://www.uniprot.org/uniprot/KCAB2_HUMAN
UniProtKB-AC	Q13303	http://www.uniprot.org/uniprot/Q13303
charge	swissprot:KCAB2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCAB2_HUMAN
eggNOG	COG0667	http://eggnogapi.embl.de/nog_data/html/tree/COG0667
eggNOG	KOG1575	http://eggnogapi.embl.de/nog_data/html/tree/KOG1575
epestfind	swissprot:KCAB2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCAB2_HUMAN
garnier	swissprot:KCAB2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCAB2_HUMAN
helixturnhelix	swissprot:KCAB2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCAB2_HUMAN
hmoment	swissprot:KCAB2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCAB2_HUMAN
iep	swissprot:KCAB2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCAB2_HUMAN
inforesidue	swissprot:KCAB2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCAB2_HUMAN
neXtProt	NX_Q13303	http://www.nextprot.org/db/entry/NX_Q13303
octanol	swissprot:KCAB2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCAB2_HUMAN
pepcoil	swissprot:KCAB2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCAB2_HUMAN
pepdigest	swissprot:KCAB2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCAB2_HUMAN
pepinfo	swissprot:KCAB2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCAB2_HUMAN
pepnet	swissprot:KCAB2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCAB2_HUMAN
pepstats	swissprot:KCAB2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCAB2_HUMAN
pepwheel	swissprot:KCAB2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCAB2_HUMAN
pepwindow	swissprot:KCAB2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCAB2_HUMAN
sigcleave	swissprot:KCAB2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCAB2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	QCR9_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UDW1-1; Sequence=Displayed; Name=2; IsoId=Q9UDW1-2; Sequence=VSP_041429; 
# AltName	QCR9_HUMAN	Complex III subunit 9
# AltName	QCR9_HUMAN	Complex III subunit X
# AltName	QCR9_HUMAN	Cytochrome c1 non-heme 7 kDa protein
# AltName	QCR9_HUMAN	Ubiquinol-cytochrome c reductase complex 7.2 kDa protein
# BioGrid	118920	17
# CCDS	CCDS46680	-. [Q9UDW1-1]
# CCDS	CCDS46681	-. [Q9UDW1-2]
# ChiTaRS	UQCR10	human
# Ensembl	ENST00000330029	ENSP00000332887; ENSG00000184076. [Q9UDW1-1]
# Ensembl	ENST00000401406	ENSP00000384962; ENSG00000184076. [Q9UDW1-2]
# FUNCTION	QCR9_HUMAN	This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1 (By similarity). {ECO 0000250}. 
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0005750	mitochondrial respiratory chain complex III; IBA:GO_Central.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0008121	ubiquinol-cytochrome-c reductase activity; NAS:UniProtKB.
# GO_process	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c; NAS:UniProtKB.
# GO_process	GO:0009060	aerobic respiration; IBA:GO_Central.
# GO_process	GO:0034551	mitochondrial respiratory chain complex III assembly; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# GOslim_process	GO:0006461	protein complex assembly
# Gene3D	1.20.5.260	-; 1.
# Genevisible	Q9UDW1	HS
# HGNC	HGNC:30863	UQCR10
# IntAct	Q9UDW1	7
# InterPro	IPR008027	QCR9
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	610843	gene
# Organism	QCR9_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12980	PTHR12980
# Pfam	PF05365	UCR_UQCRX_QCR9
# Proteomes	UP000005640	Chromosome 22
# Reactome	R-HSA-611105	Respiratory electron transport
# RecName	QCR9_HUMAN	Cytochrome b-c1 complex subunit 9
# RefSeq	NP_001003684	NM_001003684.1. [Q9UDW1-2]
# RefSeq	NP_037519	NM_013387.3. [Q9UDW1-1]
# SIMILARITY	Belongs to the UQCR10/QCR9 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	QCR9_HUMAN	Mitochondrion inner membrane {ECO 0000250}. 
# SUBUNIT	The bc1 complex contains 11 subunits	 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1). 
# SUPFAM	SSF81514	SSF81514
# TopDownProteomics	Q9UDW1-1	-. [Q9UDW1-1]
# TopDownProteomics	Q9UDW1-2	-. [Q9UDW1-2]
# UCSC	uc003agp	human. [Q9UDW1-1]
# eggNOG	ENOG410XUZE	LUCA
# eggNOG	KOG3494	Eukaryota
BLAST	swissprot:QCR9_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:QCR9_HUMAN
BioCyc	ZFISH:HS15855-MONOMER	http://biocyc.org/getid?id=ZFISH:HS15855-MONOMER
COXPRESdb	29796	http://coxpresdb.jp/data/gene/29796.shtml
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/0076-6879(95)60132-5	http://dx.doi.org/10.1016/0076-6879(95)60132-5
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/990031	http://dx.doi.org/10.1038/990031
DOI	10.1101/gr.140200	http://dx.doi.org/10.1101/gr.140200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AB028598	http://www.ebi.ac.uk/ena/data/view/AB028598
EMBL	AC004882	http://www.ebi.ac.uk/ena/data/view/AC004882
EMBL	AF161468	http://www.ebi.ac.uk/ena/data/view/AF161468
EMBL	BC005402	http://www.ebi.ac.uk/ena/data/view/BC005402
EMBL	BC015971	http://www.ebi.ac.uk/ena/data/view/BC015971
Ensembl	ENST00000330029	http://www.ensembl.org/id/ENST00000330029
Ensembl	ENST00000401406	http://www.ensembl.org/id/ENST00000401406
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005750	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005750
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0008121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008121
GO_process	GO:0006122	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006122
GO_process	GO:0009060	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009060
GO_process	GO:0034551	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034551
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
Gene3D	1.20.5.260	http://www.cathdb.info/version/latest/superfamily/1.20.5.260
GeneCards	UQCR10	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=UQCR10
GeneID	29796	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29796
GeneTree	ENSGT00390000014052	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000014052
HGNC	HGNC:30863	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:30863
HOGENOM	HOG000215187	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000215187&db=HOGENOM6
HOVERGEN	HBG056661	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG056661&db=HOVERGEN
InParanoid	Q9UDW1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UDW1
IntAct	Q9UDW1	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9UDW1*
InterPro	IPR008027	http://www.ebi.ac.uk/interpro/entry/IPR008027
Jabion	29796	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=29796
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Gene	hsa:29796	http://www.genome.jp/dbget-bin/www_bget?hsa:29796
KEGG_Orthology	KO:K00419	http://www.genome.jp/dbget-bin/www_bget?KO:K00419
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	610843	http://www.ncbi.nlm.nih.gov/omim/610843
OMA	HITEGEW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HITEGEW
PANTHER	PTHR12980	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12980
PSORT	swissprot:QCR9_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:QCR9_HUMAN
PSORT-B	swissprot:QCR9_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:QCR9_HUMAN
PSORT2	swissprot:QCR9_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:QCR9_HUMAN
Pfam	PF05365	http://pfam.xfam.org/family/PF05365
PharmGKB	PA165378374	http://www.pharmgkb.org/do/serve?objId=PA165378374&objCls=Gene
Phobius	swissprot:QCR9_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:QCR9_HUMAN
PhylomeDB	Q9UDW1	http://phylomedb.org/?seqid=Q9UDW1
ProteinModelPortal	Q9UDW1	http://www.proteinmodelportal.org/query/uniprot/Q9UDW1
PubMed	10591208	http://www.ncbi.nlm.nih.gov/pubmed/10591208
PubMed	11042152	http://www.ncbi.nlm.nih.gov/pubmed/11042152
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	8592474	http://www.ncbi.nlm.nih.gov/pubmed/8592474
Reactome	R-HSA-611105	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-611105
RefSeq	NP_001003684	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001003684
RefSeq	NP_037519	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_037519
SMR	Q9UDW1	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9UDW1
STRING	9606.ENSP00000332887	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000332887&targetmode=cogs
SUPFAM	SSF81514	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81514
UCSC	uc003agp	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003agp&org=rat
UniGene	Hs.284292	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.284292
UniProtKB	QCR9_HUMAN	http://www.uniprot.org/uniprot/QCR9_HUMAN
UniProtKB-AC	Q9UDW1	http://www.uniprot.org/uniprot/Q9UDW1
charge	swissprot:QCR9_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:QCR9_HUMAN
eggNOG	ENOG410XUZE	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XUZE
eggNOG	KOG3494	http://eggnogapi.embl.de/nog_data/html/tree/KOG3494
epestfind	swissprot:QCR9_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:QCR9_HUMAN
garnier	swissprot:QCR9_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:QCR9_HUMAN
helixturnhelix	swissprot:QCR9_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:QCR9_HUMAN
hmoment	swissprot:QCR9_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:QCR9_HUMAN
iep	swissprot:QCR9_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:QCR9_HUMAN
inforesidue	swissprot:QCR9_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:QCR9_HUMAN
neXtProt	NX_Q9UDW1	http://www.nextprot.org/db/entry/NX_Q9UDW1
octanol	swissprot:QCR9_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:QCR9_HUMAN
pepcoil	swissprot:QCR9_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:QCR9_HUMAN
pepdigest	swissprot:QCR9_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:QCR9_HUMAN
pepinfo	swissprot:QCR9_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:QCR9_HUMAN
pepnet	swissprot:QCR9_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:QCR9_HUMAN
pepstats	swissprot:QCR9_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:QCR9_HUMAN
pepwheel	swissprot:QCR9_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:QCR9_HUMAN
pepwindow	swissprot:QCR9_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:QCR9_HUMAN
sigcleave	swissprot:QCR9_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:QCR9_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	120912	67
# DISEASE	SCN3B_HUMAN	Atrial fibrillation, familial, 16 (ATFB16) [MIM 613120]  A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. {ECO 0000269|PubMed 20558140, ECO 0000269|PubMed 21051419}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCN3B_HUMAN	Brugada syndrome 7 (BRGDA7) [MIM 613120]  A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset. {ECO 0000269|Ref.8}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00313	Valproic Acid
# DrugBank	DB00909	Zonisamide
# Ensembl	ENST00000299333	ENSP00000299333; ENSG00000166257
# Ensembl	ENST00000392770	ENSP00000376523; ENSG00000166257
# Ensembl	ENST00000530277	ENSP00000432785; ENSG00000166257
# ExpressionAtlas	Q9NY72	baseline and differential
# FUNCTION	SCN3B_HUMAN	Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity). {ECO 0000250}. 
# GO_component	GO:0001518	voltage-gated sodium channel complex; IDA:BHF-UCL.
# GO_component	GO:0005886	plasma membrane; IDA:LIFEdb.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0030018	Z disc; ISS:BHF-UCL.
# GO_function	GO:0005248	voltage-gated sodium channel activity; NAS:UniProtKB.
# GO_function	GO:0017080	sodium channel regulator activity; IDA:BHF-UCL.
# GO_function	GO:0044325	ion channel binding; IPI:BHF-UCL.
# GO_function	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential; IDA:BHF-UCL.
# GO_process	GO:0006814	sodium ion transport; NAS:UniProtKB.
# GO_process	GO:0007399	nervous system development; IEA:Ensembl.
# GO_process	GO:0010460	positive regulation of heart rate; ISS:BHF-UCL.
# GO_process	GO:0010765	positive regulation of sodium ion transport; IDA:BHF-UCL.
# GO_process	GO:0019233	sensory perception of pain; IEA:Ensembl.
# GO_process	GO:0035725	sodium ion transmembrane transport; IDA:BHF-UCL.
# GO_process	GO:0051899	membrane depolarization; IDA:BHF-UCL.
# GO_process	GO:0060048	cardiac muscle contraction; IMP:BHF-UCL.
# GO_process	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization; IMP:BHF-UCL.
# GO_process	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization; IMP:BHF-UCL.
# GO_process	GO:0072659	protein localization to plasma membrane; IMP:BHF-UCL.
# GO_process	GO:0086002	cardiac muscle cell action potential involved in contraction; IMP:BHF-UCL.
# GO_process	GO:0086005	ventricular cardiac muscle cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086010	membrane depolarization during action potential; IDA:BHF-UCL.
# GO_process	GO:0086012	membrane depolarization during cardiac muscle cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086014	atrial cardiac muscle cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086015	SA node cell action potential; ISS:BHF-UCL.
# GO_process	GO:0086091	regulation of heart rate by cardiac conduction; IMP:BHF-UCL.
# GO_process	GO:2000649	regulation of sodium ion transmembrane transporter activity; IMP:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007009	plasma membrane organization
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.40.10	-; 1.
# Genevisible	Q9NY72	HS
# HGNC	HGNC:20665	SCN3B
# InterPro	IPR003599	Ig_sub
# InterPro	IPR007110	Ig-like_dom
# InterPro	IPR013106	Ig_V-set
# InterPro	IPR013783	Ig-like_fold
# InterPro	IPR027096	Na_channel_b3
# InterPro	IPR027098	Na_channel_b1/b3
# KEGG_Brite	ko04040	Ion channels
# KEGG_Disease	H00728	[Cardiovascular disease] Brugada syndrome (BRS)
# MIM	608214	gene
# MIM	613120	phenotype
# Organism	SCN3B_HUMAN	Homo sapiens (Human)
# Orphanet	130	Brugada syndrome
# Orphanet	334	Familial atrial fibrillation
# PANTHER	PTHR10546	PTHR10546
# PANTHER	PTHR10546:SF1	PTHR10546:SF1
# PDB	4L1D	X-ray; 2.50 A; A/B/C=25-145
# PROSITE	PS50835	IG_LIKE
# Pfam	PF07686	V-set
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-445095	Interaction between L1 and Ankyrins
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# RecName	SCN3B_HUMAN	Sodium channel subunit beta-3
# RefSeq	NP_001035241	NM_001040151.1
# RefSeq	NP_060870	NM_018400.3
# RefSeq	XP_011541199	XM_011542897.1
# SEQUENCE CAUTION	Sequence=BAA86472.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family. {ECO	0000305}. 
# SIMILARITY	Contains 1 Ig-like C2-type (immunoglobulin-like) domain. {ECO	0000305}. 
# SMART	SM00409	IG
# SUBCELLULAR LOCATION	SCN3B_HUMAN	Membrane; Single-pass type I membrane protein. 
# SUBUNIT	The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 and beta-4 are covalently linked by disulfide bonds (By similarity). {ECO	0000250}. 
# SUPFAM	SSF48726	SSF48726
# TISSUE SPECIFICITY	Expressed in the atrium. {ECO:0000269|PubMed	21051419}. 
# UCSC	uc001pza	human
# eggNOG	ENOG410IHF3	Eukaryota
# eggNOG	ENOG4111IPM	LUCA
BLAST	swissprot:SCN3B_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SCN3B_HUMAN
COXPRESdb	55800	http://coxpresdb.jp/data/gene/55800.shtml
CleanEx	HS_SCN3B	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SCN3B
DOI	10.1016/j.bbrc.2010.06.042	http://dx.doi.org/10.1016/j.bbrc.2010.06.042
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.030362197	http://dx.doi.org/10.1073/pnas.030362197
DOI	10.1093/cvr/cvp417	http://dx.doi.org/10.1093/cvr/cvp417
DOI	10.1093/cvr/cvq348	http://dx.doi.org/10.1093/cvr/cvq348
DOI	10.1093/dnares/6.5.329	http://dx.doi.org/10.1093/dnares/6.5.329
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1101/gr.GR1547R	http://dx.doi.org/10.1101/gr.GR1547R
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DrugBank	DB00313	http://www.drugbank.ca/drugs/DB00313
DrugBank	DB00909	http://www.drugbank.ca/drugs/DB00909
EMBL	AB032984	http://www.ebi.ac.uk/ena/data/view/AB032984
EMBL	AJ243396	http://www.ebi.ac.uk/ena/data/view/AJ243396
EMBL	AK314513	http://www.ebi.ac.uk/ena/data/view/AK314513
EMBL	AL136589	http://www.ebi.ac.uk/ena/data/view/AL136589
EMBL	BC117282	http://www.ebi.ac.uk/ena/data/view/BC117282
EMBL	BC126265	http://www.ebi.ac.uk/ena/data/view/BC126265
EMBL	DQ677666	http://www.ebi.ac.uk/ena/data/view/DQ677666
Ensembl	ENST00000299333	http://www.ensembl.org/id/ENST00000299333
Ensembl	ENST00000392770	http://www.ensembl.org/id/ENST00000392770
Ensembl	ENST00000530277	http://www.ensembl.org/id/ENST00000530277
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0001518	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001518
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030018	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030018
GO_function	GO:0005248	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005248
GO_function	GO:0017080	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017080
GO_function	GO:0044325	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044325
GO_function	GO:0086006	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086006
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0007399	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007399
GO_process	GO:0010460	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010460
GO_process	GO:0010765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010765
GO_process	GO:0019233	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019233
GO_process	GO:0035725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035725
GO_process	GO:0051899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051899
GO_process	GO:0060048	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060048
GO_process	GO:0060371	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060371
GO_process	GO:0060373	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060373
GO_process	GO:0072659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072659
GO_process	GO:0086002	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086002
GO_process	GO:0086005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086005
GO_process	GO:0086010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086010
GO_process	GO:0086012	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086012
GO_process	GO:0086014	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086014
GO_process	GO:0086015	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086015
GO_process	GO:0086091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086091
GO_process	GO:2000649	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000649
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007009
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.40.10	http://www.cathdb.info/version/latest/superfamily/2.60.40.10
GeneCards	SCN3B	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SCN3B
GeneID	55800	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55800
GeneTree	ENSGT00390000018560	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000018560
HGNC	HGNC:20665	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20665
HOGENOM	HOG000276881	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276881&db=HOGENOM6
HOVERGEN	HBG056582	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG056582&db=HOVERGEN
HPA	HPA042518	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042518
InParanoid	Q9NY72	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NY72
InterPro	IPR003599	http://www.ebi.ac.uk/interpro/entry/IPR003599
InterPro	IPR007110	http://www.ebi.ac.uk/interpro/entry/IPR007110
InterPro	IPR013106	http://www.ebi.ac.uk/interpro/entry/IPR013106
InterPro	IPR013783	http://www.ebi.ac.uk/interpro/entry/IPR013783
InterPro	IPR027096	http://www.ebi.ac.uk/interpro/entry/IPR027096
InterPro	IPR027098	http://www.ebi.ac.uk/interpro/entry/IPR027098
Jabion	55800	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55800
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00728	http://www.genome.jp/dbget-bin/www_bget?H00728
KEGG_Gene	hsa:55800	http://www.genome.jp/dbget-bin/www_bget?hsa:55800
KEGG_Orthology	KO:K04847	http://www.genome.jp/dbget-bin/www_bget?KO:K04847
MIM	608214	http://www.ncbi.nlm.nih.gov/omim/608214
MIM	613120	http://www.ncbi.nlm.nih.gov/omim/613120
MINT	MINT-4724379	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4724379
OMA	LLIEMVY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LLIEMVY
Orphanet	130	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=130
Orphanet	334	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=334
OrthoDB	EOG091G0OF7	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0OF7
PANTHER	PTHR10546	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10546
PANTHER	PTHR10546:SF1	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10546:SF1
PDB	4L1D	http://www.ebi.ac.uk/pdbe-srv/view/entry/4L1D
PDBsum	4L1D	http://www.ebi.ac.uk/pdbsum/4L1D
PROSITE	PS50835	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50835
PSORT	swissprot:SCN3B_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SCN3B_HUMAN
PSORT-B	swissprot:SCN3B_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SCN3B_HUMAN
PSORT2	swissprot:SCN3B_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SCN3B_HUMAN
Pfam	PF07686	http://pfam.xfam.org/family/PF07686
PharmGKB	PA130546912	http://www.pharmgkb.org/do/serve?objId=PA130546912&objCls=Gene
Phobius	swissprot:SCN3B_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SCN3B_HUMAN
PhylomeDB	Q9NY72	http://phylomedb.org/?seqid=Q9NY72
ProteinModelPortal	Q9NY72	http://www.proteinmodelportal.org/query/uniprot/Q9NY72
PubMed	10574461	http://www.ncbi.nlm.nih.gov/pubmed/10574461
PubMed	10688874	http://www.ncbi.nlm.nih.gov/pubmed/10688874
PubMed	11230166	http://www.ncbi.nlm.nih.gov/pubmed/11230166
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	20042427	http://www.ncbi.nlm.nih.gov/pubmed/20042427
PubMed	20558140	http://www.ncbi.nlm.nih.gov/pubmed/20558140
PubMed	21051419	http://www.ncbi.nlm.nih.gov/pubmed/21051419
Reactome	R-HSA-445095	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-445095
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
RefSeq	NP_001035241	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001035241
RefSeq	NP_060870	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060870
RefSeq	XP_011541199	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011541199
SMART	SM00409	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00409
SMR	Q9NY72	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9NY72
STRING	9606.ENSP00000299333	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000299333&targetmode=cogs
SUPFAM	SSF48726	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48726
UCSC	uc001pza	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001pza&org=rat
UniGene	Hs.4865	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.4865
UniProtKB	SCN3B_HUMAN	http://www.uniprot.org/uniprot/SCN3B_HUMAN
UniProtKB-AC	Q9NY72	http://www.uniprot.org/uniprot/Q9NY72
charge	swissprot:SCN3B_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SCN3B_HUMAN
eggNOG	ENOG410IHF3	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IHF3
eggNOG	ENOG4111IPM	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111IPM
epestfind	swissprot:SCN3B_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SCN3B_HUMAN
garnier	swissprot:SCN3B_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SCN3B_HUMAN
helixturnhelix	swissprot:SCN3B_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SCN3B_HUMAN
hmoment	swissprot:SCN3B_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SCN3B_HUMAN
iep	swissprot:SCN3B_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SCN3B_HUMAN
inforesidue	swissprot:SCN3B_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SCN3B_HUMAN
neXtProt	NX_Q9NY72	http://www.nextprot.org/db/entry/NX_Q9NY72
octanol	swissprot:SCN3B_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SCN3B_HUMAN
pepcoil	swissprot:SCN3B_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SCN3B_HUMAN
pepdigest	swissprot:SCN3B_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SCN3B_HUMAN
pepinfo	swissprot:SCN3B_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SCN3B_HUMAN
pepnet	swissprot:SCN3B_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SCN3B_HUMAN
pepstats	swissprot:SCN3B_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SCN3B_HUMAN
pepwheel	swissprot:SCN3B_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SCN3B_HUMAN
pepwindow	swissprot:SCN3B_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SCN3B_HUMAN
sigcleave	swissprot:SCN3B_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SCN3B_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNA3_HUMAN	HGK5
# AltName	KCNA3_HUMAN	HLK3
# AltName	KCNA3_HUMAN	HPCN3
# AltName	KCNA3_HUMAN	Voltage-gated K(+) channel HuKIII
# AltName	KCNA3_HUMAN	Voltage-gated potassium channel subunit Kv1.3
# BioGrid	109941	15
# CAUTION	It is uncertain whether Met-1 or Met-53 is the initiator. {ECO	0000305}. 
# DOMAIN	KCNA3_HUMAN	The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. 
# DOMAIN	KCNA3_HUMAN	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. 
# DrugBank	DB06637	Dalfampridine
# Ensembl	ENST00000369769	ENSP00000358784; ENSG00000177272
# FUNCTION	KCNA3_HUMAN	Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008076	voltage-gated potassium channel complex; TAS:ProtInc.
# GO_component	GO:0030424	axon; IEA:Ensembl.
# GO_component	GO:0045121	membrane raft; IEA:Ensembl.
# GO_function	GO:0005244	voltage-gated ion channel activity; TAS:ProtInc.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; IBA:GO_Central.
# GO_function	GO:0015271	outward rectifier potassium channel activity; IEA:Ensembl.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0051260	protein homooligomerization; IEA:InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# Gene3D	1.20.120.350	-; 1.
# Genevisible	P22001	HS
# HGNC	HGNC:6221	KCNA3
# InterPro	IPR000210	BTB/POZ_dom
# InterPro	IPR003131	T1-type_BTB
# InterPro	IPR003968	K_chnl_volt-dep_Kv
# InterPro	IPR003972	K_chnl_volt-dep_Kv1
# InterPro	IPR004050	K_chnl_volt-dep_Kv1.3
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR011333	SKP1/BTB/POZ
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko04040	Ion channels
# MIM	176263	gene
# Organism	KCNA3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11537	PTHR11537
# PDB	4BGC	X-ray; 1.20 A; A=104-204
# PIR	A38101	A38101
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01491	KVCHANNEL
# PRINTS	PR01496	SHAKERCHANEL
# PRINTS	PR01510	KV13CHANNEL
# PTM	KCNA3_HUMAN	N-glycosylation promotes the cell surface expression. {ECO 0000250}. 
# Pfam	PF00520	Ion_trans
# Pfam	PF02214	BTB_2
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# RecName	KCNA3_HUMAN	Potassium voltage-gated channel subfamily A member 3
# RefSeq	NP_002223	NM_002232.4
# SEQUENCE CAUTION	KCNA3_HUMAN	Sequence=AAA36425.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=AAA36425.1; Type=Frameshift; Positions=42; Evidence={ECO 0000305}; Sequence=AAA59457.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=AAA59457.1; Type=Frameshift; Positions=Several; Evidence={ECO 0000305}; Sequence=AAB88073.1; Type=Erroneous initiation; Evidence={ECO 0000305}; Sequence=AAC31761.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=AAC31761.1; Type=Frameshift; Positions=Several; Evidence={ECO 0000305};
# SIMILARITY	Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily. {ECO	0000305}. 
# SMART	SM00225	BTB
# SUBCELLULAR LOCATION	KCNA3_HUMAN	Cell membrane {ECO 0000250}; Multi-pass membrane protein. 
# SUBUNIT	Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4 (By similarity). {ECO	0000250}. 
# SUPFAM	SSF54695	SSF54695
# TCDB	1.A.1.2	the voltage-gated ion channel (vic) superfamily
# UCSC	uc001dzv	human
# eggNOG	COG1226	LUCA
# eggNOG	KOG1545	Eukaryota
BLAST	swissprot:KCNA3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNA3_HUMAN
BioCyc	ZFISH:ENSG00000177272-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000177272-MONOMER
COXPRESdb	3738	http://coxpresdb.jp/data/gene/3738.shtml
CleanEx	HS_KCNA3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNA3
DIP	DIP-44822N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-44822N
DOI	10.1006/geno.1994.1500	http://dx.doi.org/10.1006/geno.1994.1500
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1073/pnas.88.1.53	http://dx.doi.org/10.1073/pnas.88.1.53
DOI	10.1089/dna.1992.11.163	http://dx.doi.org/10.1089/dna.1992.11.163
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB06637	http://www.drugbank.ca/drugs/DB06637
EMBL	AL365361	http://www.ebi.ac.uk/ena/data/view/AL365361
EMBL	BC035059	http://www.ebi.ac.uk/ena/data/view/BC035059
EMBL	CH471122	http://www.ebi.ac.uk/ena/data/view/CH471122
EMBL	L23499	http://www.ebi.ac.uk/ena/data/view/L23499
EMBL	M38217	http://www.ebi.ac.uk/ena/data/view/M38217
EMBL	M55515	http://www.ebi.ac.uk/ena/data/view/M55515
EMBL	M85217	http://www.ebi.ac.uk/ena/data/view/M85217
Ensembl	ENST00000369769	http://www.ensembl.org/id/ENST00000369769
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0030424	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030424
GO_component	GO:0045121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045121
GO_function	GO:0005244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005244
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_function	GO:0015271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015271
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	KCNA3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNA3
GeneID	3738	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3738
GeneTree	ENSGT00760000118846	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118846
HGNC	HGNC:6221	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6221
HOGENOM	HOG000231015	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231015&db=HOGENOM6
HOVERGEN	HBG052230	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052230&db=HOVERGEN
HPA	HPA016625	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA016625
InParanoid	P22001	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P22001
InterPro	IPR000210	http://www.ebi.ac.uk/interpro/entry/IPR000210
InterPro	IPR003131	http://www.ebi.ac.uk/interpro/entry/IPR003131
InterPro	IPR003968	http://www.ebi.ac.uk/interpro/entry/IPR003968
InterPro	IPR003972	http://www.ebi.ac.uk/interpro/entry/IPR003972
InterPro	IPR004050	http://www.ebi.ac.uk/interpro/entry/IPR004050
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR011333	http://www.ebi.ac.uk/interpro/entry/IPR011333
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	3738	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3738
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3738	http://www.genome.jp/dbget-bin/www_bget?hsa:3738
KEGG_Orthology	KO:K04876	http://www.genome.jp/dbget-bin/www_bget?KO:K04876
MIM	176263	http://www.ncbi.nlm.nih.gov/omim/176263
MINT	MINT-1528422	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1528422
OMA	KRRMRYF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KRRMRYF
OrthoDB	EOG091G10NU	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G10NU
PANTHER	PTHR11537	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537
PDB	4BGC	http://www.ebi.ac.uk/pdbe-srv/view/entry/4BGC
PDBsum	4BGC	http://www.ebi.ac.uk/pdbsum/4BGC
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01491	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01491
PRINTS	PR01496	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01496
PRINTS	PR01510	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01510
PSORT	swissprot:KCNA3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNA3_HUMAN
PSORT-B	swissprot:KCNA3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNA3_HUMAN
PSORT2	swissprot:KCNA3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNA3_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF02214	http://pfam.xfam.org/family/PF02214
PharmGKB	PA30021	http://www.pharmgkb.org/do/serve?objId=PA30021&objCls=Gene
Phobius	swissprot:KCNA3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNA3_HUMAN
PhylomeDB	P22001	http://phylomedb.org/?seqid=P22001
ProteinModelPortal	P22001	http://www.proteinmodelportal.org/query/uniprot/P22001
PubMed	1373731	http://www.ncbi.nlm.nih.gov/pubmed/1373731
PubMed	1547020	http://www.ncbi.nlm.nih.gov/pubmed/1547020
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	1986382	http://www.ncbi.nlm.nih.gov/pubmed/1986382
PubMed	7829094	http://www.ncbi.nlm.nih.gov/pubmed/7829094
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
RefSeq	NP_002223	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002223
SMART	SM00225	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225
SMR	P22001	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P22001
STRING	9606.ENSP00000358784	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000358784&targetmode=cogs
SUPFAM	SSF54695	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54695
TCDB	1.A.1.2	http://www.tcdb.org/search/result.php?tc=1.A.1.2
UCSC	uc001dzv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001dzv&org=rat
UniGene	Hs.169948	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.169948
UniGene	Hs.619197	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.619197
UniGene	Hs.628223	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.628223
UniProtKB	KCNA3_HUMAN	http://www.uniprot.org/uniprot/KCNA3_HUMAN
UniProtKB-AC	P22001	http://www.uniprot.org/uniprot/P22001
charge	swissprot:KCNA3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNA3_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG1545	http://eggnogapi.embl.de/nog_data/html/tree/KOG1545
epestfind	swissprot:KCNA3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNA3_HUMAN
garnier	swissprot:KCNA3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNA3_HUMAN
helixturnhelix	swissprot:KCNA3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNA3_HUMAN
hmoment	swissprot:KCNA3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNA3_HUMAN
iep	swissprot:KCNA3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNA3_HUMAN
inforesidue	swissprot:KCNA3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNA3_HUMAN
neXtProt	NX_P22001	http://www.nextprot.org/db/entry/NX_P22001
octanol	swissprot:KCNA3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNA3_HUMAN
pepcoil	swissprot:KCNA3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNA3_HUMAN
pepdigest	swissprot:KCNA3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNA3_HUMAN
pepinfo	swissprot:KCNA3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNA3_HUMAN
pepnet	swissprot:KCNA3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNA3_HUMAN
pepstats	swissprot:KCNA3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNA3_HUMAN
pepwheel	swissprot:KCNA3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNA3_HUMAN
pepwindow	swissprot:KCNA3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNA3_HUMAN
sigcleave	swissprot:KCNA3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNA3_HUMAN
## Database	ID	URL or Descriptions
# AltName	BEST4_HUMAN	Vitelliform macular dystrophy 2-like protein 2
# Ensembl	ENST00000372207	ENSP00000361281; ENSG00000142959
# FUNCTION	BEST4_HUMAN	Forms calcium-sensitive chloride channels. Permeable to bicarbonate. {ECO 0000269|PubMed 12907679, ECO 0000269|PubMed 18400985}. 
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0034707	chloride channel complex; IBA:GO_Central.
# GO_function	GO:0005254	chloride channel activity; IEA:UniProtKB-KW.
# GO_process	GO:1902476	chloride transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q8NFU0	HS
# HGNC	HGNC:17106	BEST4
# InterPro	IPR000615	Bestrophin
# InterPro	IPR021134	Bestrophin/UPF0187
# KEGG_Brite	ko02000	Transporters
# MIM	607336	gene
# Organism	BEST4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10736	PTHR10736
# Pfam	PF01062	Bestrophin
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	BEST4_HUMAN	Bestrophin-4
# RefSeq	NP_695006	NM_153274.2
# RefSeq	XP_016856511	XM_017001022.1
# RefSeq	XP_016856512	XM_017001023.1
# SIMILARITY	Belongs to the bestrophin family. {ECO	0000305}.
# SUBCELLULAR LOCATION	BEST4_HUMAN	Cell membrane; Multi-pass membrane protein. 
# TISSUE SPECIFICITY	Predominantly found in colon and the weakly in fetal brain, spinal cord, retina, lung, trachea, testis and placenta. {ECO:0000269|PubMed	12032738}. 
# UCSC	uc001cmm	human
# eggNOG	ENOG410XS3J	LUCA
# eggNOG	KOG3547	Eukaryota
BLAST	swissprot:BEST4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:BEST4_HUMAN
BioCyc	ZFISH:ENSG00000142959-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000142959-MONOMER
COXPRESdb	266675	http://coxpresdb.jp/data/gene/266675.shtml
CleanEx	HS_BEST4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_BEST4
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/sj.ejhg.5200796	http://dx.doi.org/10.1038/sj.ejhg.5200796
DOI	10.1074/jbc.M306150200	http://dx.doi.org/10.1074/jbc.M306150200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1152/ajpcell.00398.2007	http://dx.doi.org/10.1152/ajpcell.00398.2007
EMBL	AF440757	http://www.ebi.ac.uk/ena/data/view/AF440757
EMBL	AL592166	http://www.ebi.ac.uk/ena/data/view/AL592166
EMBL	AY515707	http://www.ebi.ac.uk/ena/data/view/AY515707
EMBL	BC101823	http://www.ebi.ac.uk/ena/data/view/BC101823
Ensembl	ENST00000372207	http://www.ensembl.org/id/ENST00000372207
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	BEST4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=BEST4
GeneID	266675	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=266675
GeneTree	ENSGT00390000002997	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002997
HGNC	HGNC:17106	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17106
HOGENOM	HOG000115678	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000115678&db=HOGENOM6
HOVERGEN	HBG044928	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG044928&db=HOVERGEN
HPA	HPA058564	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA058564
InParanoid	Q8NFU0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8NFU0
IntAct	Q8NFU0	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8NFU0*
InterPro	IPR000615	http://www.ebi.ac.uk/interpro/entry/IPR000615
InterPro	IPR021134	http://www.ebi.ac.uk/interpro/entry/IPR021134
Jabion	266675	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=266675
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:266675	http://www.genome.jp/dbget-bin/www_bget?hsa:266675
KEGG_Orthology	KO:K13881	http://www.genome.jp/dbget-bin/www_bget?KO:K13881
MIM	607336	http://www.ncbi.nlm.nih.gov/omim/607336
MINT	MINT-7969671	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-7969671
OMA	PHSIAVF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PHSIAVF
OrthoDB	EOG091G06XO	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G06XO
PANTHER	PTHR10736	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10736
PSORT	swissprot:BEST4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:BEST4_HUMAN
PSORT-B	swissprot:BEST4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:BEST4_HUMAN
PSORT2	swissprot:BEST4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:BEST4_HUMAN
Pfam	PF01062	http://pfam.xfam.org/family/PF01062
PharmGKB	PA162377520	http://www.pharmgkb.org/do/serve?objId=PA162377520&objCls=Gene
Phobius	swissprot:BEST4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:BEST4_HUMAN
PhylomeDB	Q8NFU0	http://phylomedb.org/?seqid=Q8NFU0
ProteinModelPortal	Q8NFU0	http://www.proteinmodelportal.org/query/uniprot/Q8NFU0
PubMed	12032738	http://www.ncbi.nlm.nih.gov/pubmed/12032738
PubMed	12907679	http://www.ncbi.nlm.nih.gov/pubmed/12907679
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	18400985	http://www.ncbi.nlm.nih.gov/pubmed/18400985
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_695006	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_695006
RefSeq	XP_016856511	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016856511
RefSeq	XP_016856512	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016856512
SMR	Q8NFU0	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8NFU0
STRING	9606.ENSP00000361281	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000361281&targetmode=cogs
UCSC	uc001cmm	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001cmm&org=rat
UniGene	Hs.302513	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.302513
UniProtKB	BEST4_HUMAN	http://www.uniprot.org/uniprot/BEST4_HUMAN
UniProtKB-AC	Q8NFU0	http://www.uniprot.org/uniprot/Q8NFU0
charge	swissprot:BEST4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:BEST4_HUMAN
eggNOG	ENOG410XS3J	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS3J
eggNOG	KOG3547	http://eggnogapi.embl.de/nog_data/html/tree/KOG3547
epestfind	swissprot:BEST4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:BEST4_HUMAN
garnier	swissprot:BEST4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:BEST4_HUMAN
helixturnhelix	swissprot:BEST4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:BEST4_HUMAN
hmoment	swissprot:BEST4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:BEST4_HUMAN
iep	swissprot:BEST4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:BEST4_HUMAN
inforesidue	swissprot:BEST4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:BEST4_HUMAN
neXtProt	NX_Q8NFU0	http://www.nextprot.org/db/entry/NX_Q8NFU0
octanol	swissprot:BEST4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:BEST4_HUMAN
pepcoil	swissprot:BEST4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:BEST4_HUMAN
pepdigest	swissprot:BEST4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:BEST4_HUMAN
pepinfo	swissprot:BEST4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:BEST4_HUMAN
pepnet	swissprot:BEST4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:BEST4_HUMAN
pepstats	swissprot:BEST4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:BEST4_HUMAN
pepwheel	swissprot:BEST4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:BEST4_HUMAN
pepwindow	swissprot:BEST4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:BEST4_HUMAN
sigcleave	swissprot:BEST4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:BEST4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S39AC_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q504Y0-1; Sequence=Displayed; Name=2; IsoId=Q504Y0-2; Sequence=VSP_029847, VSP_029848; Note=No experimental confirmation available.; Name=3; IsoId=Q504Y0-3; Sequence=VSP_029849; Note=No experimental confirmation available.; Name=4; IsoId=Q504Y0-4; Sequence=VSP_029850; Note=No experimental confirmation available.; Name=5; IsoId=Q504Y0-5; Sequence=VSP_057594; 
# AltName	S39AC_HUMAN	LIV-1 subfamily of ZIP zinc transporter 8
# AltName	S39AC_HUMAN	Solute carrier family 39 member 12
# AltName	S39AC_HUMAN	Zrt- and Irt-like protein 12
# BioGrid	128681	70
# CCDS	CCDS44362	-. [Q504Y0-1]
# CCDS	CCDS60493	-. [Q504Y0-4]
# CCDS	CCDS60494	-. [Q504Y0-5]
# CCDS	CCDS7124	-. [Q504Y0-3]
# Ensembl	ENST00000377369	ENSP00000366586; ENSG00000148482. [Q504Y0-1]
# Ensembl	ENST00000377371	ENSP00000366588; ENSG00000148482. [Q504Y0-4]
# Ensembl	ENST00000377374	ENSP00000366591; ENSG00000148482. [Q504Y0-3]
# Ensembl	ENST00000539911	ENSP00000440445; ENSG00000148482. [Q504Y0-5]
# FUNCTION	S39AC_HUMAN	Acts as a zinc-influx transporter (Potential). May be partly involved in the outbreak of schizophrenia. {ECO 0000305}. 
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IEA:Ensembl.
# GO_component	GO:1903561	extracellular vesicle; IDA:UniProtKB.
# GO_function	GO:0005385	zinc ion transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0006882	cellular zinc ion homeostasis; IBA:GO_Central.
# GO_process	GO:0007165	signal transduction; IBA:GO_Central.
# GO_process	GO:0010975	regulation of neuron projection development; IEA:Ensembl.
# GO_process	GO:0031113	regulation of microtubule polymerization; IEA:Ensembl.
# GO_process	GO:0071578	zinc II ion transmembrane import; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q504Y0	HS
# HGNC	HGNC:20860	SLC39A12
# InterPro	IPR003689	ZIP
# KEGG_Brite	ko02001	Solute carrier family
# MIM	608734	gene
# Organism	S39AC_HUMAN	Homo sapiens (Human)
# Pfam	PF02535	Zip
# Proteomes	UP000005640	Chromosome 10
# RecName	S39AC_HUMAN	Zinc transporter ZIP12
# RefSeq	NP_001138667	NM_001145195.1. [Q504Y0-1]
# RefSeq	NP_001269662	NM_001282733.1. [Q504Y0-4]
# RefSeq	NP_001269663	NM_001282734.1. [Q504Y0-5]
# RefSeq	NP_689938	NM_152725.3. [Q504Y0-3]
# SIMILARITY	Belongs to the ZIP transporter (TC 2.A.5) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S39AC_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	2.A.5.4.14	the zinc (zn(2+))-iron (fe(2+)) permease (zip) family
# TISSUE SPECIFICITY	S39AC_HUMAN	Expressed in brain and eye. {ECO 0000269|PubMed 12107410, ECO 0000269|PubMed 15342556}. 
# UCSC	uc001ipn	human. [Q504Y0-1]
# UCSC	uc010qck	human
# eggNOG	COG0428	LUCA
# eggNOG	KOG2693	Eukaryota
BLAST	swissprot:S39AC_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S39AC_HUMAN
COXPRESdb	221074	http://coxpresdb.jp/data/gene/221074.shtml
CleanEx	HS_SLC39A12	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC39A12
DOI	10.1016/j.schres.2005.07.039	http://dx.doi.org/10.1016/j.schres.2005.07.039
DOI	10.1038/nature02462	http://dx.doi.org/10.1038/nature02462
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2435604	http://dx.doi.org/10.1101/gr.2435604
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
EMBL	AC069023	http://www.ebi.ac.uk/ena/data/view/AC069023
EMBL	AC069023	http://www.ebi.ac.uk/ena/data/view/AC069023
EMBL	AC069023	http://www.ebi.ac.uk/ena/data/view/AC069023
EMBL	AC069023	http://www.ebi.ac.uk/ena/data/view/AC069023
EMBL	AK055061	http://www.ebi.ac.uk/ena/data/view/AK055061
EMBL	AK295294	http://www.ebi.ac.uk/ena/data/view/AK295294
EMBL	AL360231	http://www.ebi.ac.uk/ena/data/view/AL360231
EMBL	AL360231	http://www.ebi.ac.uk/ena/data/view/AL360231
EMBL	AL360231	http://www.ebi.ac.uk/ena/data/view/AL360231
EMBL	AL360231	http://www.ebi.ac.uk/ena/data/view/AL360231
EMBL	AL590111	http://www.ebi.ac.uk/ena/data/view/AL590111
EMBL	AL590111	http://www.ebi.ac.uk/ena/data/view/AL590111
EMBL	AL590111	http://www.ebi.ac.uk/ena/data/view/AL590111
EMBL	AL590111	http://www.ebi.ac.uk/ena/data/view/AL590111
EMBL	BC035118	http://www.ebi.ac.uk/ena/data/view/BC035118
EMBL	BC047635	http://www.ebi.ac.uk/ena/data/view/BC047635
EMBL	BC065917	http://www.ebi.ac.uk/ena/data/view/BC065917
EMBL	BC094700	http://www.ebi.ac.uk/ena/data/view/BC094700
EMBL	BC117323	http://www.ebi.ac.uk/ena/data/view/BC117323
EMBL	BC143551	http://www.ebi.ac.uk/ena/data/view/BC143551
Ensembl	ENST00000377369	http://www.ensembl.org/id/ENST00000377369
Ensembl	ENST00000377371	http://www.ensembl.org/id/ENST00000377371
Ensembl	ENST00000377374	http://www.ensembl.org/id/ENST00000377374
Ensembl	ENST00000539911	http://www.ensembl.org/id/ENST00000539911
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_component	GO:1903561	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903561
GO_function	GO:0005385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005385
GO_process	GO:0006882	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006882
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0010975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010975
GO_process	GO:0031113	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031113
GO_process	GO:0071578	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071578
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC39A12	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC39A12
GeneID	221074	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=221074
GeneTree	ENSGT00760000119115	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119115
H-InvDB	HIX0008685	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0008685
H-InvDB	HIX0019390	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0019390
HGNC	HGNC:20860	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20860
HOVERGEN	HBG108449	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108449&db=HOVERGEN
InParanoid	Q504Y0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q504Y0
InterPro	IPR003689	http://www.ebi.ac.uk/interpro/entry/IPR003689
Jabion	221074	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=221074
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:221074	http://www.genome.jp/dbget-bin/www_bget?hsa:221074
KEGG_Orthology	KO:K14718	http://www.genome.jp/dbget-bin/www_bget?KO:K14718
MIM	608734	http://www.ncbi.nlm.nih.gov/omim/608734
OMA	HQEEICS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HQEEICS
OrthoDB	EOG091G035V	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G035V
PSORT	swissprot:S39AC_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S39AC_HUMAN
PSORT-B	swissprot:S39AC_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S39AC_HUMAN
PSORT2	swissprot:S39AC_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S39AC_HUMAN
Pfam	PF02535	http://pfam.xfam.org/family/PF02535
PharmGKB	PA134956205	http://www.pharmgkb.org/do/serve?objId=PA134956205&objCls=Gene
Phobius	swissprot:S39AC_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S39AC_HUMAN
PhylomeDB	Q504Y0	http://phylomedb.org/?seqid=Q504Y0
ProteinModelPortal	Q504Y0	http://www.proteinmodelportal.org/query/uniprot/Q504Y0
PubMed	12107410	http://www.ncbi.nlm.nih.gov/pubmed/12107410
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15164054	http://www.ncbi.nlm.nih.gov/pubmed/15164054
PubMed	15342556	http://www.ncbi.nlm.nih.gov/pubmed/15342556
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16311021	http://www.ncbi.nlm.nih.gov/pubmed/16311021
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
RefSeq	NP_001138667	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001138667
RefSeq	NP_001269662	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269662
RefSeq	NP_001269663	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269663
RefSeq	NP_689938	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_689938
SMR	Q504Y0	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q504Y0
STRING	9606.ENSP00000366586	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000366586&targetmode=cogs
TCDB	2.A.5.4.14	http://www.tcdb.org/search/result.php?tc=2.A.5.4.14
UCSC	uc001ipn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001ipn&org=rat
UCSC	uc010qck	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010qck&org=rat
UniGene	Hs.350895	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.350895
UniProtKB	S39AC_HUMAN	http://www.uniprot.org/uniprot/S39AC_HUMAN
UniProtKB-AC	Q504Y0	http://www.uniprot.org/uniprot/Q504Y0
charge	swissprot:S39AC_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S39AC_HUMAN
eggNOG	COG0428	http://eggnogapi.embl.de/nog_data/html/tree/COG0428
eggNOG	KOG2693	http://eggnogapi.embl.de/nog_data/html/tree/KOG2693
epestfind	swissprot:S39AC_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S39AC_HUMAN
garnier	swissprot:S39AC_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S39AC_HUMAN
helixturnhelix	swissprot:S39AC_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S39AC_HUMAN
hmoment	swissprot:S39AC_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S39AC_HUMAN
iep	swissprot:S39AC_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S39AC_HUMAN
inforesidue	swissprot:S39AC_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S39AC_HUMAN
neXtProt	NX_Q504Y0	http://www.nextprot.org/db/entry/NX_Q504Y0
octanol	swissprot:S39AC_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S39AC_HUMAN
pepcoil	swissprot:S39AC_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S39AC_HUMAN
pepdigest	swissprot:S39AC_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S39AC_HUMAN
pepinfo	swissprot:S39AC_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S39AC_HUMAN
pepnet	swissprot:S39AC_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S39AC_HUMAN
pepstats	swissprot:S39AC_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S39AC_HUMAN
pepwheel	swissprot:S39AC_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S39AC_HUMAN
pepwindow	swissprot:S39AC_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S39AC_HUMAN
sigcleave	swissprot:S39AC_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S39AC_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ABCAC_HUMAN	Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q86UK0-1; Sequence=Displayed; Name=2; IsoId=Q86UK0-2; Sequence=VSP_011283, VSP_011284; Note=No experimental confirmation available.; 
# AltName	ABCAC_HUMAN	ATP-binding cassette transporter 12
# CCDS	CCDS33372	-. [Q86UK0-1]
# CCDS	CCDS33373	-. [Q86UK0-2]
# DISEASE	ABCAC_HUMAN	Ichthyosis, congenital, autosomal recessive 4A (ARCI4A) [MIM 601277]  A form of autosomal recessive congenital ichthyosis, a disorder of keratinization with abnormal differentiation and desquamation of the epidermis, resulting in abnormal skin scaling over the whole body. The main skin phenotypes are lamellar ichthyosis (LI) and non-bullous congenital ichthyosiform erythroderma (NCIE), although phenotypic overlap within the same patient or among patients from the same family can occur. Lamellar ichthyosis is a condition often associated with an embedment in a collodion-like membrane at birth; skin scales later develop, covering the entire body surface. Non-bullous congenital ichthyosiform erythroderma characterized by fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs. {ECO 0000269|PubMed 12915478, ECO 0000269|PubMed 17508018, ECO 0000269|PubMed 18284401, ECO 0000269|PubMed 19262603, ECO 0000269|PubMed 22257947}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ABCAC_HUMAN	Ichthyosis, congenital, autosomal recessive 4B (ARCI4B) [MIM 242500]  A rare, very severe form of congenital ichthyosis, in which the neonate is born with a thick covering of armor-like scales. The skin dries out to form hard diamond-shaped plaques separated by fissures, resembling 'armor plating'. The normal facial features are severely affected, with distortion of the lips (eclabion), eyelids (ectropion), ears, and nostrils. Affected babies are often born prematurely and rarely survive the perinatal period. Babies who survive into infancy and beyond develop skin changes resembling severe non-bullous congenital ichthyosiform erythroderma. {ECO 0000269|PubMed 15756637, ECO 0000269|PubMed 16675967, ECO 0000269|PubMed 16902423}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	ABCAC_HUMAN	Multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. {ECO 0000250}. 
# Ensembl	ENST00000272895	ENSP00000272895; ENSG00000144452. [Q86UK0-1]
# Ensembl	ENST00000389661	ENSP00000374312; ENSG00000144452. [Q86UK0-2]
# ExpressionAtlas	Q86UK0	baseline and differential
# FUNCTION	ABCAC_HUMAN	Probable transporter involved in lipid homeostasis. 
# GO_component	GO:0005737	cytoplasm; IDA:BHF-UCL.
# GO_component	GO:0005743	mitochondrial inner membrane; IEA:Ensembl.
# GO_component	GO:0005829	cytosol; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0097209	epidermal lamellar body; IDA:BHF-UCL.
# GO_function	GO:0005102	receptor binding; IPI:BHF-UCL.
# GO_function	GO:0005319	lipid transporter activity; IDA:BHF-UCL.
# GO_function	GO:0005524	ATP binding; NAS:UniProtKB.
# GO_function	GO:0034040	lipid-transporting ATPase activity; IC:BHF-UCL.
# GO_function	GO:0034191	apolipoprotein A-I receptor binding; IPI:BHF-UCL.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; IBA:GO_Central.
# GO_process	GO:0006869	lipid transport; NAS:UniProtKB.
# GO_process	GO:0010875	positive regulation of cholesterol efflux; IDA:BHF-UCL.
# GO_process	GO:0019725	cellular homeostasis; NAS:UniProtKB.
# GO_process	GO:0031424	keratinization; IEA:Ensembl.
# GO_process	GO:0032940	secretion by cell; IMP:BHF-UCL.
# GO_process	GO:0033700	phospholipid efflux; IMP:BHF-UCL.
# GO_process	GO:0035627	ceramide transport; IEA:Ensembl.
# GO_process	GO:0043129	surfactant homeostasis; IEA:Ensembl.
# GO_process	GO:0045055	regulated exocytosis; IMP:BHF-UCL.
# GO_process	GO:0048286	lung alveolus development; IEA:Ensembl.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GO_process	GO:0055088	lipid homeostasis; IEA:Ensembl.
# GO_process	GO:0061436	establishment of skin barrier; IEA:Ensembl.
# GO_process	GO:0072659	protein localization to plasma membrane; IDA:BHF-UCL.
# GO_process	GO:2000010	positive regulation of protein localization to cell surface; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007009	plasma membrane organization
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 2.
# Genevisible	Q86UK0	HS
# HGNC	HGNC:14637	ABCA12
# INTERACTION	ABCAC_HUMAN	O95477 ABCA1; NbExp=4; IntAct=EBI-9541582, EBI-784112; 
# IntAct	Q86UK0	2
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR026082	ABC_A
# InterPro	IPR027417	P-loop_NTPase
# InterPro	IPR030371	ABCA12
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Disease	H00733	[Congenital disorder; Skin and connective tissue disease] Harlequin ichthyosis
# KEGG_Disease	H00734	[Congenital disorder; Skin and connective tissue disease] Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
# KEGG_Pathway	ko02010	ABC transporters
# MIM	242500	phenotype
# MIM	601277	phenotype
# MIM	607800	gene
# Organism	ABCAC_HUMAN	Homo sapiens (Human)
# Orphanet	313	Lamellar ichthyosis
# Orphanet	457	Harlequin ichthyosis
# Orphanet	79394	Congenital non-bullous ichthyosiform erythroderma
# PANTHER	PTHR19229	PTHR19229; 3
# PANTHER	PTHR19229:SF29	PTHR19229:SF29; 3
# PIR	T12512	T12512
# PROSITE	PS00211	ABC_TRANSPORTER_1
# PROSITE	PS50893	ABC_TRANSPORTER_2; 2
# Pfam	PF00005	ABC_tran; 2
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-1369062	ABC transporters in lipid homeostasis
# RecName	ABCAC_HUMAN	ATP-binding cassette sub-family A member 12
# RefSeq	NP_056472	NM_015657.3. [Q86UK0-2]
# RefSeq	NP_775099	NM_173076.2. [Q86UK0-1]
# SEQUENCE CAUTION	Sequence=AAN40735.1; Type=Erroneous initiation; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCA family. {ECO	0000305}. 
# SIMILARITY	Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA; 2
# SUBCELLULAR LOCATION	ABCAC_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF52540	SSF52540; 2
# TCDB	3.A.1.211.13	the atp-binding cassette (abc) superfamily
# TISSUE SPECIFICITY	Mainly expressed in the stomach, placenta, testis and fetal brain. {ECO:0000269|PubMed	12697999}. 
# UCSC	uc002vev	human. [Q86UK0-1]
# WEB RESOURCE	ABCAC_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=Q86UK0";
# eggNOG	COG1131	LUCA
# eggNOG	KOG0059	Eukaryota
BLAST	swissprot:ABCAC_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCAC_HUMAN
COXPRESdb	26154	http://coxpresdb.jp/data/gene/26154.shtml
CleanEx	HS_ABCA12	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCA12
DOI	10.1002/humu.21326	http://dx.doi.org/10.1002/humu.21326
DOI	10.1038/jid.2009.23	http://dx.doi.org/10.1038/jid.2009.23
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/sj.jid.5700295	http://dx.doi.org/10.1038/sj.jid.5700295
DOI	10.1038/sj.jid.5700455	http://dx.doi.org/10.1038/sj.jid.5700455
DOI	10.1038/sj.jid.5700885	http://dx.doi.org/10.1038/sj.jid.5700885
DOI	10.1086/429844	http://dx.doi.org/10.1086/429844
DOI	10.1093/hmg/ddg235	http://dx.doi.org/10.1093/hmg/ddg235
DOI	10.1111/j.1365-2133.2008.08439.x	http://dx.doi.org/10.1111/j.1365-2133.2008.08439.x
DOI	10.1126/science.1164368	http://dx.doi.org/10.1126/science.1164368
DOI	10.1159/000069811	http://dx.doi.org/10.1159/000069811
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.1684/ejd.2011.1638	http://dx.doi.org/10.1684/ejd.2011.1638
EMBL	AC072062	http://www.ebi.ac.uk/ena/data/view/AC072062
EMBL	AC114780	http://www.ebi.ac.uk/ena/data/view/AC114780
EMBL	AF418105	http://www.ebi.ac.uk/ena/data/view/AF418105
EMBL	AL080207	http://www.ebi.ac.uk/ena/data/view/AL080207
EMBL	AY033486	http://www.ebi.ac.uk/ena/data/view/AY033486
EMBL	AY219711	http://www.ebi.ac.uk/ena/data/view/AY219711
Ensembl	ENST00000272895	http://www.ensembl.org/id/ENST00000272895
Ensembl	ENST00000389661	http://www.ensembl.org/id/ENST00000389661
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0097209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097209
GO_function	GO:0005102	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005102
GO_function	GO:0005319	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005319
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0034040	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034040
GO_function	GO:0034191	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034191
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GO_process	GO:0006869	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006869
GO_process	GO:0010875	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010875
GO_process	GO:0019725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019725
GO_process	GO:0031424	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031424
GO_process	GO:0032940	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032940
GO_process	GO:0033700	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033700
GO_process	GO:0035627	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035627
GO_process	GO:0043129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043129
GO_process	GO:0045055	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045055
GO_process	GO:0048286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048286
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GO_process	GO:0055088	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055088
GO_process	GO:0061436	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061436
GO_process	GO:0072659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072659
GO_process	GO:2000010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000010
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007009
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCA12	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCA12
GeneID	26154	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26154
GeneTree	ENSGT00760000118965	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118965
HGNC	HGNC:14637	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14637
HOGENOM	HOG000168538	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000168538&db=HOGENOM6
HOVERGEN	HBG080807	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG080807&db=HOVERGEN
InParanoid	Q86UK0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q86UK0
IntAct	Q86UK0	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q86UK0*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR026082	http://www.ebi.ac.uk/interpro/entry/IPR026082
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
InterPro	IPR030371	http://www.ebi.ac.uk/interpro/entry/IPR030371
Jabion	26154	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=26154
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Disease	H00733	http://www.genome.jp/dbget-bin/www_bget?H00733
KEGG_Disease	H00734	http://www.genome.jp/dbget-bin/www_bget?H00734
KEGG_Gene	hsa:26154	http://www.genome.jp/dbget-bin/www_bget?hsa:26154
KEGG_Orthology	KO:K05646	http://www.genome.jp/dbget-bin/www_bget?KO:K05646
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
MIM	242500	http://www.ncbi.nlm.nih.gov/omim/242500
MIM	601277	http://www.ncbi.nlm.nih.gov/omim/601277
MIM	607800	http://www.ncbi.nlm.nih.gov/omim/607800
OMA	NYSPPHR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NYSPPHR
Orphanet	313	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=313
Orphanet	457	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=457
Orphanet	79394	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=79394
OrthoDB	EOG091G007E	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G007E
PANTHER	PTHR19229	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19229
PANTHER	PTHR19229:SF29	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19229:SF29
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PSORT	swissprot:ABCAC_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCAC_HUMAN
PSORT-B	swissprot:ABCAC_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCAC_HUMAN
PSORT2	swissprot:ABCAC_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCAC_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
PharmGKB	PA29604	http://www.pharmgkb.org/do/serve?objId=PA29604&objCls=Gene
Phobius	swissprot:ABCAC_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCAC_HUMAN
PhylomeDB	Q86UK0	http://phylomedb.org/?seqid=Q86UK0
ProteinModelPortal	Q86UK0	http://www.proteinmodelportal.org/query/uniprot/Q86UK0
PubMed	12697999	http://www.ncbi.nlm.nih.gov/pubmed/12697999
PubMed	12915478	http://www.ncbi.nlm.nih.gov/pubmed/12915478
PubMed	15756637	http://www.ncbi.nlm.nih.gov/pubmed/15756637
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	16675967	http://www.ncbi.nlm.nih.gov/pubmed/16675967
PubMed	16902423	http://www.ncbi.nlm.nih.gov/pubmed/16902423
PubMed	17508018	http://www.ncbi.nlm.nih.gov/pubmed/17508018
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18284401	http://www.ncbi.nlm.nih.gov/pubmed/18284401
PubMed	18772397	http://www.ncbi.nlm.nih.gov/pubmed/18772397
PubMed	19262603	http://www.ncbi.nlm.nih.gov/pubmed/19262603
PubMed	20672373	http://www.ncbi.nlm.nih.gov/pubmed/20672373
PubMed	22257947	http://www.ncbi.nlm.nih.gov/pubmed/22257947
Reactome	R-HSA-1369062	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1369062
RefSeq	NP_056472	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_056472
RefSeq	NP_775099	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_775099
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	Q86UK0	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q86UK0
STRING	9606.ENSP00000272895	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000272895&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TCDB	3.A.1.211.13	http://www.tcdb.org/search/result.php?tc=3.A.1.211.13
UCSC	uc002vev	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002vev&org=rat
UniGene	Hs.134585	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.134585
UniProtKB	ABCAC_HUMAN	http://www.uniprot.org/uniprot/ABCAC_HUMAN
UniProtKB-AC	Q86UK0	http://www.uniprot.org/uniprot/Q86UK0
charge	swissprot:ABCAC_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCAC_HUMAN
eggNOG	COG1131	http://eggnogapi.embl.de/nog_data/html/tree/COG1131
eggNOG	KOG0059	http://eggnogapi.embl.de/nog_data/html/tree/KOG0059
epestfind	swissprot:ABCAC_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCAC_HUMAN
garnier	swissprot:ABCAC_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCAC_HUMAN
helixturnhelix	swissprot:ABCAC_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCAC_HUMAN
hmoment	swissprot:ABCAC_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCAC_HUMAN
iep	swissprot:ABCAC_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCAC_HUMAN
inforesidue	swissprot:ABCAC_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCAC_HUMAN
neXtProt	NX_Q86UK0	http://www.nextprot.org/db/entry/NX_Q86UK0
octanol	swissprot:ABCAC_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCAC_HUMAN
pepcoil	swissprot:ABCAC_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCAC_HUMAN
pepdigest	swissprot:ABCAC_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCAC_HUMAN
pepinfo	swissprot:ABCAC_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCAC_HUMAN
pepnet	swissprot:ABCAC_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCAC_HUMAN
pepstats	swissprot:ABCAC_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCAC_HUMAN
pepwheel	swissprot:ABCAC_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCAC_HUMAN
pepwindow	swissprot:ABCAC_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCAC_HUMAN
sigcleave	swissprot:ABCAC_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCAC_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S12A8_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=A0AV02-1; Sequence=Displayed; Name=2; IsoId=A0AV02-2; Sequence=VSP_028330; Note=No experimental confirmation available.; Name=3; IsoId=A0AV02-3; Sequence=VSP_028329, VSP_028331; Note=No experimental confirmation available.; Name=4; IsoId=A0AV02-4; Sequence=VSP_028328, VSP_028332; Note=No experimental confirmation available.; Name=5; IsoId=A0AV02-5; Sequence=VSP_028327; Note=No experimental confirmation available.; 
# AltName	S12A8_HUMAN	Cation-chloride cotransporter 9
# CCDS	CCDS43143	-. [A0AV02-1]
# ChiTaRS	SLC12A8	human
# DISEASE	S12A8_HUMAN	Note=SLC12A8 has been identified as a possible susceptibility gene for psoriasis mapped to chromosome 3q21 (PSORS5). 
# Ensembl	ENST00000393469	ENSP00000377112; ENSG00000221955. [A0AV02-1]
# Ensembl	ENST00000430155	ENSP00000415713; ENSG00000221955. [A0AV02-3]
# Ensembl	ENST00000469902	ENSP00000418783; ENSG00000221955. [A0AV02-1]
# ExpressionAtlas	A0AV02	baseline and differential
# FUNCTION	S12A8_HUMAN	Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation. {ECO 0000269|PubMed 11863360}. 
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_process	GO:0006813	potassium ion transport; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	A0AV02	HS
# HGNC	HGNC:15595	SLC12A8
# IntAct	A0AV02	2
# InterPro	IPR004841	AA-permease/SLC12A_dom
# KEGG_Brite	ko02001	Solute carrier family
# MIM	611316	gene
# Organism	S12A8_HUMAN	Homo sapiens (Human)
# Pfam	PF00324	AA_permease
# Proteomes	UP000005640	Chromosome 3
# RecName	S12A8_HUMAN	Solute carrier family 12 member 8
# RefSeq	NP_001182412	NM_001195483.1
# RefSeq	NP_078904	NM_024628.5
# SEQUENCE CAUTION	S12A8_HUMAN	Sequence=AAH20506.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=AAH63528.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=AAH63528.1; Type=Frameshift; Positions=569; Evidence={ECO 0000305}; Sequence=AAK94307.1; Type=Erroneous gene model prediction; Evidence={ECO 0000305}; Sequence=AAM73657.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=CAD97969.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305};
# SIMILARITY	Belongs to the SLC12A transporter family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S12A8_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	2.A.30.3	the cation-chloride cotransporter (ccc) family
# TISSUE SPECIFICITY	Ubiquitous with very low level in normal skin. {ECO:0000269|PubMed	11863360}. 
# TopDownProteomics	A0AV02-3	-. [A0AV02-3]
# TopDownProteomics	A0AV02-5	-. [A0AV02-5]
# UCSC	uc003eht	human. [A0AV02-1]
# eggNOG	COG0531	LUCA
# eggNOG	KOG2083	Eukaryota
BLAST	swissprot:S12A8_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S12A8_HUMAN
BioCyc	ZFISH:G66-32932-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32932-MONOMER
COXPRESdb	84561	http://coxpresdb.jp/data/gene/84561.shtml
DOI	10.1006/geno.2002.6720	http://dx.doi.org/10.1006/geno.2002.6720
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.0022-202X.2005.23847.x	http://dx.doi.org/10.1111/j.0022-202X.2005.23847.x
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AC055752	http://www.ebi.ac.uk/ena/data/view/AC055752
EMBL	AC108688	http://www.ebi.ac.uk/ena/data/view/AC108688
EMBL	AC117488	http://www.ebi.ac.uk/ena/data/view/AC117488
EMBL	AF345197	http://www.ebi.ac.uk/ena/data/view/AF345197
EMBL	AF389851	http://www.ebi.ac.uk/ena/data/view/AF389851
EMBL	AF390442	http://www.ebi.ac.uk/ena/data/view/AF390442
EMBL	AK026841	http://www.ebi.ac.uk/ena/data/view/AK026841
EMBL	BC020506	http://www.ebi.ac.uk/ena/data/view/BC020506
EMBL	BC063528	http://www.ebi.ac.uk/ena/data/view/BC063528
EMBL	BC126158	http://www.ebi.ac.uk/ena/data/view/BC126158
EMBL	BC126160	http://www.ebi.ac.uk/ena/data/view/BC126160
EMBL	BX538023	http://www.ebi.ac.uk/ena/data/view/BX538023
EMBL	CR457363	http://www.ebi.ac.uk/ena/data/view/CR457363
EMBL	CR749632	http://www.ebi.ac.uk/ena/data/view/CR749632
Ensembl	ENST00000393469	http://www.ensembl.org/id/ENST00000393469
Ensembl	ENST00000430155	http://www.ensembl.org/id/ENST00000430155
Ensembl	ENST00000469902	http://www.ensembl.org/id/ENST00000469902
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC12A8	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC12A8
GeneID	84561	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84561
GeneTree	ENSGT00760000119053	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119053
HGNC	HGNC:15595	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:15595
HOVERGEN	HBG108430	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108430&db=HOVERGEN
HPA	HPA031123	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031123
InParanoid	A0AV02	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=A0AV02
IntAct	A0AV02	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=A0AV02*
InterPro	IPR004841	http://www.ebi.ac.uk/interpro/entry/IPR004841
Jabion	84561	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=84561
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:84561	http://www.genome.jp/dbget-bin/www_bget?hsa:84561
KEGG_Orthology	KO:K14428	http://www.genome.jp/dbget-bin/www_bget?KO:K14428
MIM	611316	http://www.ncbi.nlm.nih.gov/omim/611316
OMA	TKNWYSG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TKNWYSG
OrthoDB	EOG091G02VO	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02VO
PSORT	swissprot:S12A8_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S12A8_HUMAN
PSORT-B	swissprot:S12A8_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S12A8_HUMAN
PSORT2	swissprot:S12A8_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S12A8_HUMAN
Pfam	PF00324	http://pfam.xfam.org/family/PF00324
PharmGKB	PA37991	http://www.pharmgkb.org/do/serve?objId=PA37991&objCls=Gene
Phobius	swissprot:S12A8_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S12A8_HUMAN
ProteinModelPortal	A0AV02	http://www.proteinmodelportal.org/query/uniprot/A0AV02
PubMed	11863360	http://www.ncbi.nlm.nih.gov/pubmed/11863360
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16297188	http://www.ncbi.nlm.nih.gov/pubmed/16297188
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
RefSeq	NP_001182412	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001182412
RefSeq	NP_078904	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_078904
STRING	9606.ENSP00000377112	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000377112&targetmode=cogs
TCDB	2.A.30.3	http://www.tcdb.org/search/result.php?tc=2.A.30.3
UCSC	uc003eht	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003eht&org=rat
UniGene	Hs.658514	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.658514
UniProtKB	S12A8_HUMAN	http://www.uniprot.org/uniprot/S12A8_HUMAN
UniProtKB-AC	A0AV02	http://www.uniprot.org/uniprot/A0AV02
charge	swissprot:S12A8_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S12A8_HUMAN
eggNOG	COG0531	http://eggnogapi.embl.de/nog_data/html/tree/COG0531
eggNOG	KOG2083	http://eggnogapi.embl.de/nog_data/html/tree/KOG2083
epestfind	swissprot:S12A8_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S12A8_HUMAN
garnier	swissprot:S12A8_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S12A8_HUMAN
helixturnhelix	swissprot:S12A8_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S12A8_HUMAN
hmoment	swissprot:S12A8_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S12A8_HUMAN
iep	swissprot:S12A8_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S12A8_HUMAN
inforesidue	swissprot:S12A8_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S12A8_HUMAN
neXtProt	NX_A0AV02	http://www.nextprot.org/db/entry/NX_A0AV02
octanol	swissprot:S12A8_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S12A8_HUMAN
pepcoil	swissprot:S12A8_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S12A8_HUMAN
pepdigest	swissprot:S12A8_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S12A8_HUMAN
pepinfo	swissprot:S12A8_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S12A8_HUMAN
pepnet	swissprot:S12A8_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S12A8_HUMAN
pepstats	swissprot:S12A8_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S12A8_HUMAN
pepwheel	swissprot:S12A8_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S12A8_HUMAN
pepwindow	swissprot:S12A8_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S12A8_HUMAN
sigcleave	swissprot:S12A8_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S12A8_HUMAN
## Database	ID	URL or Descriptions
# AltName	MCAT_HUMAN	Carnitine/acylcarnitine translocase
# AltName	MCAT_HUMAN	Solute carrier family 25 member 20
# BioGrid	107241	20
# DISEASE	MCAT_HUMAN	Carnitine-acylcarnitine translocase deficiency (CACTD) [MIM 212138]  A rare long-chain fatty acid oxidation disorder. Metabolic consequences include hypoketotic hypoglycemia under fasting conditions, hyperammonemia, elevated creatine kinase and transaminases, dicarboxylic aciduria, very low free carnitine and abnormal acylcarnitine profile with marked elevation of the long- chain acylcarnitines. Clinical features include neurologic abnormalities, cardiomyopathy, arrhythmias, skeletal muscle damage, liver dysfunction and episodes of life-threatening coma, which eventually lead to death. Most patients become symptomatic in the neonatal period with a rapidly progressive deterioration and a high mortality rate. {ECO 0000269|PubMed 12859414, ECO 0000269|PubMed 15057979, ECO 0000269|PubMed 15365988}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00583	L-Carnitine
# Ensembl	ENST00000319017	ENSP00000326305; ENSG00000178537
# ExpressionAtlas	O43772	baseline and differential
# FUNCTION	MCAT_HUMAN	Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway. 
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015227	acyl carnitine transmembrane transporter activity; EXP:Reactome.
# GO_process	GO:0006853	carnitine shuttle; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005739	mitochondrion
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.50.40.10	-; 1.
# Genevisible	O43772	HS
# HGNC	HGNC:1421	SLC25A20
# IntAct	O43772	6
# InterPro	IPR018108	Mitochondrial_sb/sol_carrier
# InterPro	IPR023395	Mt_carrier_dom
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H00525	[Inherited metabolic disease] Systemic primary carnitine deficiency (CDSP)
# KEGG_Disease	H01400:[Inherited metabolic disease] Glutamine synthetase deficiency [DS	H00923]
# MIM	212138	phenotype
# MIM	613698	gene
# Organism	MCAT_HUMAN	Homo sapiens (Human)
# Orphanet	159	Carnitine-acylcarnitine translocase deficiency
# PROSITE	PS50920	SOLCAR; 3
# Pfam	PF00153	Mito_carr; 3
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-200425	Import of palmitoyl-CoA into the mitochondrial matrix
# RecName	MCAT_HUMAN	Mitochondrial carnitine/acylcarnitine carrier protein
# RefSeq	NP_000378	NM_000387.5
# SIMILARITY	Belongs to the mitochondrial carrier (TC 2.A.29) family. {ECO	0000305}. 
# SIMILARITY	Contains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule	PRU00282}.
# SUBCELLULAR LOCATION	MCAT_HUMAN	Mitochondrion inner membrane; Multi-pass membrane protein. 
# SUPFAM	SSF103506	SSF103506
# TCDB	2.A.29.8	the mitochondrial carrier (mc) family
# UCSC	uc003cva	human
# eggNOG	ENOG410XS86	LUCA
# eggNOG	KOG0758	Eukaryota
BLAST	swissprot:MCAT_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MCAT_HUMAN
BioCyc	MetaCyc:ENSG00000178537-MONOMER	http://biocyc.org/getid?id=MetaCyc:ENSG00000178537-MONOMER
BioCyc	ZFISH:ENSG00000178537-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000178537-MONOMER
COXPRESdb	788	http://coxpresdb.jp/data/gene/788.shtml
CleanEx	HS_SLC25A20	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC25A20
DOI	10.1002/ajmg.a.20573	http://dx.doi.org/10.1002/ajmg.a.20573
DOI	10.1002/humu.20085	http://dx.doi.org/10.1002/humu.20085
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/bbrc.1998.9738	http://dx.doi.org/10.1006/bbrc.1998.9738
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1034/j.1399-0004.2003.00117.x	http://dx.doi.org/10.1034/j.1399-0004.2003.00117.x
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1086/301628	http://dx.doi.org/10.1086/301628
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DrugBank	DB00583	http://www.drugbank.ca/drugs/DB00583
EMBL	AK312962	http://www.ebi.ac.uk/ena/data/view/AK312962
EMBL	BC001689	http://www.ebi.ac.uk/ena/data/view/BC001689
EMBL	Y10319	http://www.ebi.ac.uk/ena/data/view/Y10319
EMBL	Y17775	http://www.ebi.ac.uk/ena/data/view/Y17775
EMBL	Y17776	http://www.ebi.ac.uk/ena/data/view/Y17776
EMBL	Y17777	http://www.ebi.ac.uk/ena/data/view/Y17777
EMBL	Y17778	http://www.ebi.ac.uk/ena/data/view/Y17778
EMBL	Y17779	http://www.ebi.ac.uk/ena/data/view/Y17779
Ensembl	ENST00000319017	http://www.ensembl.org/id/ENST00000319017
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015227	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015227
GO_process	GO:0006853	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006853
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.50.40.10	http://www.cathdb.info/version/latest/superfamily/1.50.40.10
GeneCards	SLC25A20	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC25A20
GeneID	788	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=788
GeneTree	ENSGT00700000104295	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00700000104295
HGNC	HGNC:1421	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1421
HOGENOM	HOG000168307	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000168307&db=HOGENOM6
HOVERGEN	HBG003500	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003500&db=HOVERGEN
HPA	HPA016862	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA016862
HPA	HPA029863	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA029863
InParanoid	O43772	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O43772
IntAct	O43772	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O43772*
InterPro	IPR018108	http://www.ebi.ac.uk/interpro/entry/IPR018108
InterPro	IPR023395	http://www.ebi.ac.uk/interpro/entry/IPR023395
Jabion	788	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=788
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00525	http://www.genome.jp/dbget-bin/www_bget?H00525
KEGG_Disease	H01400	http://www.genome.jp/dbget-bin/www_bget?H01400
KEGG_Gene	hsa:788	http://www.genome.jp/dbget-bin/www_bget?hsa:788
KEGG_Orthology	KO:K15109	http://www.genome.jp/dbget-bin/www_bget?KO:K15109
MIM	212138	http://www.ncbi.nlm.nih.gov/omim/212138
MIM	613698	http://www.ncbi.nlm.nih.gov/omim/613698
MINT	MINT-1370660	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1370660
OMA	AGKSHNE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AGKSHNE
Orphanet	159	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=159
OrthoDB	EOG091G0HVE	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0HVE
PROSITE	PS50920	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50920
PSORT	swissprot:MCAT_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MCAT_HUMAN
PSORT-B	swissprot:MCAT_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MCAT_HUMAN
PSORT2	swissprot:MCAT_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MCAT_HUMAN
Pfam	PF00153	http://pfam.xfam.org/family/PF00153
PharmGKB	PA35031	http://www.pharmgkb.org/do/serve?objId=PA35031&objCls=Gene
Phobius	swissprot:MCAT_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MCAT_HUMAN
PhylomeDB	O43772	http://phylomedb.org/?seqid=O43772
ProteinModelPortal	O43772	http://www.proteinmodelportal.org/query/uniprot/O43772
PubMed	12859414	http://www.ncbi.nlm.nih.gov/pubmed/12859414
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15057979	http://www.ncbi.nlm.nih.gov/pubmed/15057979
PubMed	15365988	http://www.ncbi.nlm.nih.gov/pubmed/15365988
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	9399886	http://www.ncbi.nlm.nih.gov/pubmed/9399886
PubMed	9837782	http://www.ncbi.nlm.nih.gov/pubmed/9837782
Reactome	R-HSA-200425	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-200425
RefSeq	NP_000378	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000378
STRING	9606.ENSP00000326305	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000326305&targetmode=cogs
SUPFAM	SSF103506	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103506
TCDB	2.A.29.8	http://www.tcdb.org/search/result.php?tc=2.A.29.8
UCSC	uc003cva	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003cva&org=rat
UniGene	Hs.13845	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.13845
UniProtKB	MCAT_HUMAN	http://www.uniprot.org/uniprot/MCAT_HUMAN
UniProtKB-AC	O43772	http://www.uniprot.org/uniprot/O43772
charge	swissprot:MCAT_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MCAT_HUMAN
eggNOG	ENOG410XS86	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS86
eggNOG	KOG0758	http://eggnogapi.embl.de/nog_data/html/tree/KOG0758
epestfind	swissprot:MCAT_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MCAT_HUMAN
garnier	swissprot:MCAT_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MCAT_HUMAN
helixturnhelix	swissprot:MCAT_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MCAT_HUMAN
hmoment	swissprot:MCAT_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MCAT_HUMAN
iep	swissprot:MCAT_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MCAT_HUMAN
inforesidue	swissprot:MCAT_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MCAT_HUMAN
neXtProt	NX_O43772	http://www.nextprot.org/db/entry/NX_O43772
octanol	swissprot:MCAT_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MCAT_HUMAN
pepcoil	swissprot:MCAT_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MCAT_HUMAN
pepdigest	swissprot:MCAT_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MCAT_HUMAN
pepinfo	swissprot:MCAT_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MCAT_HUMAN
pepnet	swissprot:MCAT_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MCAT_HUMAN
pepstats	swissprot:MCAT_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MCAT_HUMAN
pepwheel	swissprot:MCAT_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MCAT_HUMAN
pepwindow	swissprot:MCAT_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MCAT_HUMAN
sigcleave	swissprot:MCAT_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MCAT_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=SLC2A9-L; IsoId=Q9NRM0-1; Sequence=Displayed; Name=2; Synonyms=GLUT9deltaN, SLC2A9-S; IsoId=Q9NRM0-2; Sequence=VSP_034860; Note=Variant in position: 17	A->T (in dbSNP:6820230).; 
# AltName	GTR9_HUMAN	Glucose transporter type 9
# CCDS	CCDS3406	-. [Q9NRM0-2]
# CCDS	CCDS3407	-. [Q9NRM0-1]
# CDD	cd06174	MFS
# DISEASE	GTR9_HUMAN	Hypouricemia renal 2 (RHUC2) [MIM 612076]  A disorder characterized by impaired uric acid reabsorption at the apical membrane of proximal renal tubule cells, and high urinary urate excretion. Patients often appear asymptomatic, but may be subject to exercise-induced acute renal failure, chronic renal dysfunction and nephrolithiasis. {ECO 0000269|PubMed 19026395, ECO 0000269|PubMed 19926891, ECO 0000269|PubMed 21810765}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00678	Losartan
# DrugBank	DB01032	Probenecid
# Ensembl	ENST00000264784	ENSP00000264784; ENSG00000109667. [Q9NRM0-1]
# Ensembl	ENST00000309065	ENSP00000311383; ENSG00000109667. [Q9NRM0-2]
# Ensembl	ENST00000506583	ENSP00000422209; ENSG00000109667. [Q9NRM0-2]
# ExpressionAtlas	Q9NRM0	baseline and differential
# FUNCTION	GTR9_HUMAN	Transport urate and fructose. May have a role in the urate reabsorption by proximal tubules. Also transports glucose at low rate. {ECO 0000269|PubMed 14739288, ECO 0000269|PubMed 18327257}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016324	apical plasma membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0005355	glucose transmembrane transporter activity; IEA:Ensembl.
# GO_function	GO:0015143	urate transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0022857	transmembrane transporter activity; TAS:Reactome.
# GO_function	GTR9_HUMAN	GO 0005351 sugar proton symporter activity; NAS UniProtKB.
# GO_process	GO:0015758	glucose transport; NAS:UniProtKB.
# GO_process	GO:0046415	urate metabolic process; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# Genevisible	Q9NRM0	HS
# HGNC	HGNC:13446	SLC2A9
# InterPro	IPR003663	Sugar/inositol_transpt
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR005829	Sugar_transporter_CS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H00948	[Urinary system disease] Renal hypouricemia (RHUC)
# MIM	606142	gene
# MIM	612076	phenotype
# Organism	GTR9_HUMAN	Homo sapiens (Human)
# Orphanet	94088	Hereditary renal hypouricemia
# POLYMORPHISM	Genetic variations in SLC2A9 influence the variance in serum uric acid concentrations and define the serum uric acid concentration quantitative trait locus 2 (UAQTL2) [MIM	612076]. Excess serum accumulation of uric acid can lead to the development of gout. 
# PRINTS	PR00171	SUGRTRNSPORT
# PROSITE	PS00216	SUGAR_TRANSPORT_1
# PROSITE	PS00217	SUGAR_TRANSPORT_2
# PROSITE	PS50850	MFS
# Pfam	PF00083	Sugar_tr
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-428776	Class II GLUTs
# RecName	GTR9_HUMAN	Solute carrier family 2, facilitated glucose transporter member 9
# RefSeq	NP_001001290	NM_001001290.1. [Q9NRM0-2]
# RefSeq	NP_064425	NM_020041.2. [Q9NRM0-1]
# SIMILARITY	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	GTR9_HUMAN	Isoform 1  Basolateral cell membrane {ECO 0000269|PubMed 14739288, ECO 0000269|PubMed 24409316}; Multi- pass membrane protein {ECO 0000269|PubMed 14739288}. 
# SUBCELLULAR LOCATION	GTR9_HUMAN	Isoform 2  Apical cell membrane {ECO 0000269|PubMed 24409316}; Multi-pass membrane protein. Basolateral cell membrane {ECO 0000269|PubMed 14739288, ECO 0000269|PubMed 24409316}; Multi-pass membrane protein {ECO 0000269|PubMed 14739288}. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.1.1.72	the major facilitator superfamily (mfs)
# TIGRFAMs	TIGR00879	SP
# TISSUE SPECIFICITY	GTR9_HUMAN	Most strongly expressed in basolateral membranes of proximal renal tubular cells, liver and placenta. Also detected in lung, blood leukocytes, heart skeletal muscle and chondrocytes from articular cartilage. Isoform 2 is only detected in the apical membranes of polarized renal tubular cells and placenta. Isoform 1 and isoform 2 are detected in kidney membrane (at protein level). {ECO 0000269|PubMed 11991658, ECO 0000269|PubMed 24409316}. 
# UCSC	uc003gmc	human. [Q9NRM0-1]
# eggNOG	COG0477	LUCA
# eggNOG	KOG0569	Eukaryota
BLAST	swissprot:GTR9_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GTR9_HUMAN
BioCyc	ZFISH:ENSG00000109667-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000109667-MONOMER
COXPRESdb	56606	http://coxpresdb.jp/data/gene/56606.shtml
CleanEx	HS_SLC2A9	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC2A9
DOI	10.1006/cbir.2001.0850	http://dx.doi.org/10.1006/cbir.2001.0850
DOI	10.1006/geno.2000.6195	http://dx.doi.org/10.1006/geno.2000.6195
DOI	10.1016/j.ajhg.2008.11.001	http://dx.doi.org/10.1016/j.ajhg.2008.11.001
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng.106	http://dx.doi.org/10.1038/ng.106
DOI	10.1038/ng.107	http://dx.doi.org/10.1038/ng.107
DOI	10.1074/jbc.M312226200	http://dx.doi.org/10.1074/jbc.M312226200
DOI	10.1093/ndt/gfr419	http://dx.doi.org/10.1093/ndt/gfr419
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1371/journal.pone.0084996	http://dx.doi.org/10.1371/journal.pone.0084996
DOI	10.1371/journal.pone.0107902	http://dx.doi.org/10.1371/journal.pone.0107902
DOI	10.1681/ASN.2009040406	http://dx.doi.org/10.1681/ASN.2009040406
DrugBank	DB00678	http://www.drugbank.ca/drugs/DB00678
DrugBank	DB01032	http://www.drugbank.ca/drugs/DB01032
EMBL	AC005674	http://www.ebi.ac.uk/ena/data/view/AC005674
EMBL	AC098976	http://www.ebi.ac.uk/ena/data/view/AC098976
EMBL	AC108199	http://www.ebi.ac.uk/ena/data/view/AC108199
EMBL	AF210317	http://www.ebi.ac.uk/ena/data/view/AF210317
EMBL	AF421859	http://www.ebi.ac.uk/ena/data/view/AF421859
EMBL	BC018897	http://www.ebi.ac.uk/ena/data/view/BC018897
EMBL	BC110414	http://www.ebi.ac.uk/ena/data/view/BC110414
Ensembl	ENST00000264784	http://www.ensembl.org/id/ENST00000264784
Ensembl	ENST00000309065	http://www.ensembl.org/id/ENST00000309065
Ensembl	ENST00000506583	http://www.ensembl.org/id/ENST00000506583
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_function	GO:0005351	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005351
GO_function	GO:0005355	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005355
GO_function	GO:0015143	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015143
GO_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GO_process	GO:0015758	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015758
GO_process	GO:0046415	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046415
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GeneCards	SLC2A9	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC2A9
GeneID	56606	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56606
GeneTree	ENSGT00760000119022	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119022
H-InvDB	HIX0004090	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0004090
HGNC	HGNC:13446	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13446
HOGENOM	HOG000202871	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202871&db=HOGENOM6
HOVERGEN	HBG014816	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG014816&db=HOVERGEN
HPA	HPA066229	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA066229
InParanoid	Q9NRM0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NRM0
InterPro	IPR003663	http://www.ebi.ac.uk/interpro/entry/IPR003663
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR005829	http://www.ebi.ac.uk/interpro/entry/IPR005829
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	56606	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=56606
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00948	http://www.genome.jp/dbget-bin/www_bget?H00948
KEGG_Gene	hsa:56606	http://www.genome.jp/dbget-bin/www_bget?hsa:56606
KEGG_Orthology	KO:K08146	http://www.genome.jp/dbget-bin/www_bget?KO:K08146
MIM	606142	http://www.ncbi.nlm.nih.gov/omim/606142
MIM	612076	http://www.ncbi.nlm.nih.gov/omim/612076
OMA	VFATICI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VFATICI
Orphanet	94088	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=94088
OrthoDB	EOG091G0A9K	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0A9K
PRINTS	PR00171	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00171
PROSITE	PS00216	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00216
PROSITE	PS00217	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00217
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:GTR9_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GTR9_HUMAN
PSORT-B	swissprot:GTR9_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GTR9_HUMAN
PSORT2	swissprot:GTR9_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GTR9_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
PharmGKB	PA37771	http://www.pharmgkb.org/do/serve?objId=PA37771&objCls=Gene
Phobius	swissprot:GTR9_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GTR9_HUMAN
PhylomeDB	Q9NRM0	http://phylomedb.org/?seqid=Q9NRM0
ProteinModelPortal	Q9NRM0	http://www.proteinmodelportal.org/query/uniprot/Q9NRM0
PubMed	10860667	http://www.ncbi.nlm.nih.gov/pubmed/10860667
PubMed	11991658	http://www.ncbi.nlm.nih.gov/pubmed/11991658
PubMed	14739288	http://www.ncbi.nlm.nih.gov/pubmed/14739288
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	18327256	http://www.ncbi.nlm.nih.gov/pubmed/18327256
PubMed	18327257	http://www.ncbi.nlm.nih.gov/pubmed/18327257
PubMed	19026395	http://www.ncbi.nlm.nih.gov/pubmed/19026395
PubMed	19926891	http://www.ncbi.nlm.nih.gov/pubmed/19926891
PubMed	21810765	http://www.ncbi.nlm.nih.gov/pubmed/21810765
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	24409316	http://www.ncbi.nlm.nih.gov/pubmed/24409316
PubMed	25268603	http://www.ncbi.nlm.nih.gov/pubmed/25268603
Reactome	R-HSA-428776	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428776
RefSeq	NP_001001290	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001001290
RefSeq	NP_064425	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_064425
STRING	9606.ENSP00000264784	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000264784&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.1.72	http://www.tcdb.org/search/result.php?tc=2.A.1.1.72
TIGRFAMs	TIGR00879	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00879
UCSC	uc003gmc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003gmc&org=rat
UniGene	Hs.444612	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.444612
UniGene	Hs.656895	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.656895
UniProtKB	GTR9_HUMAN	http://www.uniprot.org/uniprot/GTR9_HUMAN
UniProtKB-AC	Q9NRM0	http://www.uniprot.org/uniprot/Q9NRM0
charge	swissprot:GTR9_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GTR9_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG0569	http://eggnogapi.embl.de/nog_data/html/tree/KOG0569
epestfind	swissprot:GTR9_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GTR9_HUMAN
garnier	swissprot:GTR9_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GTR9_HUMAN
helixturnhelix	swissprot:GTR9_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GTR9_HUMAN
hmoment	swissprot:GTR9_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GTR9_HUMAN
iep	swissprot:GTR9_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GTR9_HUMAN
inforesidue	swissprot:GTR9_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GTR9_HUMAN
neXtProt	NX_Q9NRM0	http://www.nextprot.org/db/entry/NX_Q9NRM0
octanol	swissprot:GTR9_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GTR9_HUMAN
pepcoil	swissprot:GTR9_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GTR9_HUMAN
pepdigest	swissprot:GTR9_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GTR9_HUMAN
pepinfo	swissprot:GTR9_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GTR9_HUMAN
pepnet	swissprot:GTR9_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GTR9_HUMAN
pepstats	swissprot:GTR9_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GTR9_HUMAN
pepwheel	swissprot:GTR9_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GTR9_HUMAN
pepwindow	swissprot:GTR9_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GTR9_HUMAN
sigcleave	swissprot:GTR9_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GTR9_HUMAN
## Database	ID	URL or Descriptions
# AltName	SL9P1_HUMAN	Solute carrier family 9 subfamily B member 1 pseudogene 1
# CAUTION	Could be the product of a pseudogene. {ECO	0000305}.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	SL9P1_HUMAN	GO 0015299 solute proton antiporter activity; IEA InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# HGNC	HGNC:37492	SLC9B1P1
# InterPro	IPR006153	Cation/H_exchanger
# Organism	SL9P1_HUMAN	Homo sapiens (Human)
# Pfam	PF00999	Na_H_Exchanger
# Proteomes	UP000005640	Unplaced
# RecName	SL9P1_HUMAN	Putative SLC9B1-like protein SLC9B1P1
# SIMILARITY	Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	SL9P1_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# eggNOG	COG0025	LUCA
# eggNOG	KOG3826	Eukaryota
BLAST	swissprot:SL9P1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SL9P1_HUMAN
DOI	10.1038/nature01722	http://dx.doi.org/10.1038/nature01722
EMBL	AC134882	http://www.ebi.ac.uk/ena/data/view/AC134882
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015299	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015299
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GeneCards	SLC9B1P1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC9B1P1
HGNC	HGNC:37492	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:37492
HOGENOM	HOG000113779	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000113779&db=HOGENOM6
InParanoid	A6NJY1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=A6NJY1
InterPro	IPR006153	http://www.ebi.ac.uk/interpro/entry/IPR006153
PSORT	swissprot:SL9P1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SL9P1_HUMAN
PSORT-B	swissprot:SL9P1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SL9P1_HUMAN
PSORT2	swissprot:SL9P1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SL9P1_HUMAN
Pfam	PF00999	http://pfam.xfam.org/family/PF00999
Phobius	swissprot:SL9P1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SL9P1_HUMAN
ProteinModelPortal	A6NJY1	http://www.proteinmodelportal.org/query/uniprot/A6NJY1
PubMed	12815422	http://www.ncbi.nlm.nih.gov/pubmed/12815422
STRING	9606.ENSP00000331938	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000331938&targetmode=cogs
UniProtKB	SL9P1_HUMAN	http://www.uniprot.org/uniprot/SL9P1_HUMAN
UniProtKB-AC	A6NJY1	http://www.uniprot.org/uniprot/A6NJY1
charge	swissprot:SL9P1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SL9P1_HUMAN
eggNOG	COG0025	http://eggnogapi.embl.de/nog_data/html/tree/COG0025
eggNOG	KOG3826	http://eggnogapi.embl.de/nog_data/html/tree/KOG3826
epestfind	swissprot:SL9P1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SL9P1_HUMAN
garnier	swissprot:SL9P1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SL9P1_HUMAN
helixturnhelix	swissprot:SL9P1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SL9P1_HUMAN
hmoment	swissprot:SL9P1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SL9P1_HUMAN
iep	swissprot:SL9P1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SL9P1_HUMAN
inforesidue	swissprot:SL9P1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SL9P1_HUMAN
neXtProt	NX_A6NJY1	http://www.nextprot.org/db/entry/NX_A6NJY1
octanol	swissprot:SL9P1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SL9P1_HUMAN
pepcoil	swissprot:SL9P1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SL9P1_HUMAN
pepdigest	swissprot:SL9P1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SL9P1_HUMAN
pepinfo	swissprot:SL9P1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SL9P1_HUMAN
pepnet	swissprot:SL9P1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SL9P1_HUMAN
pepstats	swissprot:SL9P1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SL9P1_HUMAN
pepwheel	swissprot:SL9P1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SL9P1_HUMAN
pepwindow	swissprot:SL9P1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SL9P1_HUMAN
sigcleave	swissprot:SL9P1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SL9P1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S39AA_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ULF5-1; Sequence=Displayed; Name=2; IsoId=Q9ULF5-2; Sequence=VSP_055991; Note=No experimental confirmation available.; 
# AltName	S39AA_HUMAN	Solute carrier family 39 member 10
# AltName	S39AA_HUMAN	Zrt- and Irt-like protein 10
# BioGrid	121430	29
# CCDS	CCDS33353	-. [Q9ULF5-1]
# ChiTaRS	SLC39A10	human
# Ensembl	ENST00000359634	ENSP00000352655; ENSG00000196950. [Q9ULF5-1]
# Ensembl	ENST00000409086	ENSP00000386766; ENSG00000196950. [Q9ULF5-1]
# ExpressionAtlas	Q9ULF5	baseline and differential
# FUNCTION	S39AA_HUMAN	May act as a zinc-influx transporter. {ECO 0000269|PubMed 17359283}. 
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0005385	zinc ion transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0002903	negative regulation of B cell apoptotic process; IEA:Ensembl.
# GO_process	GO:0006882	cellular zinc ion homeostasis; IBA:GO_Central.
# GO_process	GO:0030890	positive regulation of B cell proliferation; IEA:Ensembl.
# GO_process	GO:0050861	positive regulation of B cell receptor signaling pathway; IBA:GO_Central.
# GO_process	GO:0071578	zinc II ion transmembrane import; IBA:GO_Central.
# GO_process	GO:1903615	positive regulation of protein tyrosine phosphatase activity; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9ULF5	HS
# HGNC	HGNC:20861	SLC39A10
# IntAct	Q9ULF5	21
# InterPro	IPR003689	ZIP
# KEGG_Brite	ko02001	Solute carrier family
# MIM	608733	gene
# MISCELLANEOUS	S39AA_HUMAN	High levels of expression are correlated with invasiveness in several breast cancer lines. 
# Organism	S39AA_HUMAN	Homo sapiens (Human)
# PIR	T08684	T08684
# Pfam	PF02535	Zip
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-442380	Zinc influx into cells by the SLC39 gene family
# RecName	S39AA_HUMAN	Zinc transporter ZIP10
# RefSeq	NP_001120729	NM_001127257.1. [Q9ULF5-1]
# RefSeq	NP_065075	NM_020342.2. [Q9ULF5-1]
# RefSeq	XP_005246746	XM_005246689.4. [Q9ULF5-1]
# RefSeq	XP_011509806	XM_011511504.2. [Q9ULF5-1]
# RefSeq	XP_011509807	XM_011511505.2. [Q9ULF5-1]
# RefSeq	XP_011509808	XM_011511506.2. [Q9ULF5-1]
# SEQUENCE CAUTION	Sequence=BAA86579.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB43393.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the ZIP transporter (TC 2.A.5) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S39AA_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	2.A.5.4	the zinc (zn(2+))-iron (fe(2+)) permease (zip) family
# UCSC	uc002utg	human. [Q9ULF5-1]
# eggNOG	COG0428	LUCA
# eggNOG	KOG2693	Eukaryota
BLAST	swissprot:S39AA_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S39AA_HUMAN
BioCyc	ZFISH:G66-31289-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31289-MONOMER
COXPRESdb	57181	http://coxpresdb.jp/data/gene/57181.shtml
CleanEx	HS_SLC39A10	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC39A10
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/dnares/6.5.337	http://dx.doi.org/10.1093/dnares/6.5.337
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1349-7006.2007.00446.x	http://dx.doi.org/10.1111/j.1349-7006.2007.00446.x
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AB033091	http://www.ebi.ac.uk/ena/data/view/AB033091
EMBL	AC013274	http://www.ebi.ac.uk/ena/data/view/AC013274
EMBL	AC064834	http://www.ebi.ac.uk/ena/data/view/AC064834
EMBL	AK291241	http://www.ebi.ac.uk/ena/data/view/AK291241
EMBL	AK294771	http://www.ebi.ac.uk/ena/data/view/AK294771
EMBL	AL050294	http://www.ebi.ac.uk/ena/data/view/AL050294
EMBL	BC073909	http://www.ebi.ac.uk/ena/data/view/BC073909
EMBL	BC101516	http://www.ebi.ac.uk/ena/data/view/BC101516
EMBL	BC112223	http://www.ebi.ac.uk/ena/data/view/BC112223
EMBL	CH471063	http://www.ebi.ac.uk/ena/data/view/CH471063
EMBL	CR749813	http://www.ebi.ac.uk/ena/data/view/CR749813
Ensembl	ENST00000359634	http://www.ensembl.org/id/ENST00000359634
Ensembl	ENST00000409086	http://www.ensembl.org/id/ENST00000409086
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005385
GO_process	GO:0002903	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002903
GO_process	GO:0006882	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006882
GO_process	GO:0030890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030890
GO_process	GO:0050861	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050861
GO_process	GO:0071578	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071578
GO_process	GO:1903615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903615
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC39A10	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC39A10
GeneID	57181	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57181
GeneTree	ENSGT00760000119115	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119115
H-InvDB	HIX0002690	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0002690
HGNC	HGNC:20861	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20861
HOGENOM	HOG000013093	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000013093&db=HOGENOM6
HOVERGEN	HBG055748	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG055748&db=HOVERGEN
HPA	HPA036512	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA036512
HPA	HPA036513	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA036513
HPA	HPA066087	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA066087
InParanoid	Q9ULF5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9ULF5
IntAct	Q9ULF5	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9ULF5*
InterPro	IPR003689	http://www.ebi.ac.uk/interpro/entry/IPR003689
Jabion	57181	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=57181
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:57181	http://www.genome.jp/dbget-bin/www_bget?hsa:57181
KEGG_Orthology	KO:K14716	http://www.genome.jp/dbget-bin/www_bget?KO:K14716
MIM	608733	http://www.ncbi.nlm.nih.gov/omim/608733
OMA	DPGHGHQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DPGHGHQ
OrthoDB	EOG091G02WM	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02WM
PSORT	swissprot:S39AA_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S39AA_HUMAN
PSORT-B	swissprot:S39AA_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S39AA_HUMAN
PSORT2	swissprot:S39AA_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S39AA_HUMAN
Pfam	PF02535	http://pfam.xfam.org/family/PF02535
PharmGKB	PA134944068	http://www.pharmgkb.org/do/serve?objId=PA134944068&objCls=Gene
Phobius	swissprot:S39AA_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S39AA_HUMAN
PhylomeDB	Q9ULF5	http://phylomedb.org/?seqid=Q9ULF5
ProteinModelPortal	Q9ULF5	http://www.proteinmodelportal.org/query/uniprot/Q9ULF5
PubMed	10574462	http://www.ncbi.nlm.nih.gov/pubmed/10574462
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	17359283	http://www.ncbi.nlm.nih.gov/pubmed/17359283
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
Reactome	R-HSA-442380	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442380
RefSeq	NP_001120729	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001120729
RefSeq	NP_065075	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_065075
RefSeq	XP_005246746	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005246746
RefSeq	XP_011509806	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011509806
RefSeq	XP_011509807	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011509807
RefSeq	XP_011509808	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011509808
STRING	9606.ENSP00000352655	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000352655&targetmode=cogs
TCDB	2.A.5.4	http://www.tcdb.org/search/result.php?tc=2.A.5.4
UCSC	uc002utg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002utg&org=rat
UniGene	Hs.650158	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.650158
UniProtKB	S39AA_HUMAN	http://www.uniprot.org/uniprot/S39AA_HUMAN
UniProtKB-AC	Q9ULF5	http://www.uniprot.org/uniprot/Q9ULF5
charge	swissprot:S39AA_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S39AA_HUMAN
eggNOG	COG0428	http://eggnogapi.embl.de/nog_data/html/tree/COG0428
eggNOG	KOG2693	http://eggnogapi.embl.de/nog_data/html/tree/KOG2693
epestfind	swissprot:S39AA_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S39AA_HUMAN
garnier	swissprot:S39AA_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S39AA_HUMAN
helixturnhelix	swissprot:S39AA_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S39AA_HUMAN
hmoment	swissprot:S39AA_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S39AA_HUMAN
iep	swissprot:S39AA_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S39AA_HUMAN
inforesidue	swissprot:S39AA_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S39AA_HUMAN
neXtProt	NX_Q9ULF5	http://www.nextprot.org/db/entry/NX_Q9ULF5
octanol	swissprot:S39AA_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S39AA_HUMAN
pepcoil	swissprot:S39AA_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S39AA_HUMAN
pepdigest	swissprot:S39AA_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S39AA_HUMAN
pepinfo	swissprot:S39AA_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S39AA_HUMAN
pepnet	swissprot:S39AA_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S39AA_HUMAN
pepstats	swissprot:S39AA_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S39AA_HUMAN
pepwheel	swissprot:S39AA_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S39AA_HUMAN
pepwindow	swissprot:S39AA_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S39AA_HUMAN
sigcleave	swissprot:S39AA_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S39AA_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GAS6_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=gas6SV; IsoId=Q14393-1; Sequence=Displayed; Name=2; IsoId=Q14393-2; Sequence=VSP_010494; Name=3; IsoId=Q14393-3; Sequence=VSP_010492, VSP_010493, VSP_010494; Note=No experimental confirmation available.; Name=4; IsoId=Q14393-4; Sequence=VSP_043832, VSP_010494; Name=5; IsoId=Q14393-5; Sequence=VSP_045685; Note=No experimental confirmation available.; 
# AltName	GAS6_HUMAN	AXL receptor tyrosine kinase ligand
# BioGrid	108891	24
# CCDS	CCDS45072	-. [Q14393-2]
# ChiTaRS	GAS6	human
# Ensembl	ENST00000327773	ENSP00000331831; ENSG00000183087. [Q14393-2]
# FUNCTION	GAS6_HUMAN	(Microbial infection) Can bridges virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry (PubMed 21501828). Plays a role in Dengue cell entry by apoptotic mimicry (PubMed 23084921). Plays a role in Vaccinia virus cell entry by apoptotic mimicry (PubMed 21501828). Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry (PubMed 17005688). {ECO 0000269|PubMed 17005688, ECO 0000269|PubMed 21501828, ECO 0000269|PubMed 23084921}. 
# FUNCTION	GAS6_HUMAN	Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. {ECO 0000269|PubMed 12364394, ECO 0000269|PubMed 18840707}. 
# GO_component	GO:0005576	extracellular region; TAS:Reactome.
# GO_component	GO:0005615	extracellular space; IDA:UniProtKB.
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005788	endoplasmic reticulum lumen; TAS:Reactome.
# GO_component	GO:0005796	Golgi lumen; TAS:Reactome.
# GO_component	GO:0031093	platelet alpha granule lumen; TAS:Reactome.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0001786	phosphatidylserine binding; IDA:UniProtKB.
# GO_function	GO:0005102	receptor binding; IDA:UniProtKB.
# GO_function	GO:0005245	voltage-gated calcium channel activity; IDA:UniProtKB.
# GO_function	GO:0005509	calcium ion binding; IEA:InterPro.
# GO_function	GO:0030296	protein tyrosine kinase activator activity; IDA:UniProtKB.
# GO_function	GO:0030971	receptor tyrosine kinase binding; IPI:UniProtKB.
# GO_function	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IDA:UniProtKB.
# GO_function	GO:0048018	receptor agonist activity; IDA:MGI.
# GO_function	GO:0060090	binding, bridging; IDA:UniProtKB.
# GO_process	GO:0001764	neuron migration; IEA:Ensembl.
# GO_process	GO:0001934	positive regulation of protein phosphorylation; IDA:UniProtKB.
# GO_process	GO:0001961	positive regulation of cytokine-mediated signaling pathway; IMP:UniProtKB.
# GO_process	GO:0002576	platelet degranulation; TAS:Reactome.
# GO_process	GO:0003104	positive regulation of glomerular filtration; ISS:UniProtKB.
# GO_process	GO:0006465	signal peptide processing; TAS:Reactome.
# GO_process	GO:0006468	protein phosphorylation; IDA:UniProtKB.
# GO_process	GO:0006888	ER to Golgi vesicle-mediated transport; TAS:Reactome.
# GO_process	GO:0006909	phagocytosis; IDA:UniProtKB.
# GO_process	GO:0007050	cell cycle arrest; TAS:UniProtKB.
# GO_process	GO:0007155	cell adhesion; TAS:UniProtKB.
# GO_process	GO:0007165	signal transduction; IDA:UniProtKB.
# GO_process	GO:0007167	enzyme linked receptor protein signaling pathway; IEA:Ensembl.
# GO_process	GO:0008283	cell proliferation; TAS:UniProtKB.
# GO_process	GO:0009267	cellular response to starvation; IEA:Ensembl.
# GO_process	GO:0010628	positive regulation of gene expression; IDA:UniProtKB.
# GO_process	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway; IDA:UniProtKB.
# GO_process	GO:0010934	macrophage cytokine production; IEA:Ensembl.
# GO_process	GO:0016477	cell migration; TAS:UniProtKB.
# GO_process	GO:0018105	peptidyl-serine phosphorylation; IDA:UniProtKB.
# GO_process	GO:0019064	fusion of virus membrane with host plasma membrane; IDA:UniProtKB.
# GO_process	GO:0019079	viral genome replication; IDA:UniProtKB.
# GO_process	GO:0030168	platelet activation; TAS:UniProtKB.
# GO_process	GO:0031100	animal organ regeneration; IEA:Ensembl.
# GO_process	GO:0031589	cell-substrate adhesion; IEA:Ensembl.
# GO_process	GO:0032008	positive regulation of TOR signaling; ISS:UniProtKB.
# GO_process	GO:0032148	activation of protein kinase B activity; ISS:UniProtKB.
# GO_process	GO:0032689	negative regulation of interferon-gamma production; IDA:UniProtKB.
# GO_process	GO:0032715	negative regulation of interleukin-6 production; IDA:UniProtKB.
# GO_process	GO:0032720	negative regulation of tumor necrosis factor production; IDA:UniProtKB.
# GO_process	GO:0032825	positive regulation of natural killer cell differentiation; IDA:UniProtKB.
# GO_process	GO:0033138	positive regulation of peptidyl-serine phosphorylation; IDA:UniProtKB.
# GO_process	GO:0033159	negative regulation of protein import into nucleus, translocation; IDA:UniProtKB.
# GO_process	GO:0035457	cellular response to interferon-alpha; IDA:UniProtKB.
# GO_process	GO:0035690	cellular response to drug; IDA:UniProtKB.
# GO_process	GO:0035754	B cell chemotaxis; IDA:UniProtKB.
# GO_process	GO:0040008	regulation of growth; IEA:UniProtKB-KW.
# GO_process	GO:0043066	negative regulation of apoptotic process; IDA:UniProtKB.
# GO_process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.
# GO_process	GO:0043277	apoptotic cell clearance; IDA:UniProtKB.
# GO_process	GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
# GO_process	GO:0043491	protein kinase B signaling; IDA:UniProtKB.
# GO_process	GO:0045860	positive regulation of protein kinase activity; IDA:UniProtKB.
# GO_process	GO:0045892	negative regulation of transcription, DNA-templated; IDA:UniProtKB.
# GO_process	GO:0046718	viral entry into host cell; IDA:UniProtKB.
# GO_process	GO:0046813	receptor-mediated virion attachment to host cell; IDA:UniProtKB.
# GO_process	GO:0046827	positive regulation of protein export from nucleus; IDA:UniProtKB.
# GO_process	GO:0048146	positive regulation of fibroblast proliferation; IDA:UniProtKB.
# GO_process	GO:0050711	negative regulation of interleukin-1 secretion; IDA:UniProtKB.
# GO_process	GO:0050766	positive regulation of phagocytosis; IDA:UniProtKB.
# GO_process	GO:0050900	leukocyte migration; TAS:Reactome.
# GO_process	GO:0051897	positive regulation of protein kinase B signaling; IDA:UniProtKB.
# GO_process	GO:0061098	positive regulation of protein tyrosine kinase activity; IDA:UniProtKB.
# GO_process	GO:0070168	negative regulation of biomineral tissue development; IDA:UniProtKB.
# GO_process	GO:0070374	positive regulation of ERK1 and ERK2 cascade; IDA:MGI.
# GO_process	GO:0070527	platelet aggregation; TAS:UniProtKB.
# GO_process	GO:0070588	calcium ion transmembrane transport; IDA:UniProtKB.
# GO_process	GO:0071307	cellular response to vitamin K; IDA:UniProtKB.
# GO_process	GO:0071333	cellular response to glucose stimulus; ISS:UniProtKB.
# GO_process	GO:0071363	cellular response to growth factor stimulus; IEA:Ensembl.
# GO_process	GO:0072661	protein targeting to plasma membrane; IDA:UniProtKB.
# GO_process	GO:0085029	extracellular matrix assembly; ISS:UniProtKB.
# GO_process	GO:0097028	dendritic cell differentiation; IEP:UniProtKB.
# GO_process	GO:0097241	hematopoietic stem cell migration to bone marrow; IDA:UniProtKB.
# GO_process	GO:1900142	negative regulation of oligodendrocyte apoptotic process; IDA:UniProtKB.
# GO_process	GO:1900165	negative regulation of interleukin-6 secretion; IDA:UniProtKB.
# GO_process	GO:2000270	negative regulation of fibroblast apoptotic process; IDA:UniProtKB.
# GO_process	GO:2000352	negative regulation of endothelial cell apoptotic process; IDA:UniProtKB.
# GO_process	GO:2000510	positive regulation of dendritic cell chemotaxis; IDA:UniProtKB.
# GO_process	GO:2000533	negative regulation of renal albumin absorption; ISS:UniProtKB.
# GO_process	GO:2000669	negative regulation of dendritic cell apoptotic process; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005576	extracellular region
# GOslim_component	GO:0005615	extracellular space
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0008289	lipid binding
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0030234	enzyme regulator activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0006605	protein targeting
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007155	cell adhesion
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0008283	cell proliferation
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0022607	cellular component assembly
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0030198	extracellular matrix organization
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0048870	cell motility
# GOslim_process	GO:0051604	protein maturation
# GOslim_process	GO:0055085	transmembrane transport
# GOslim_process	GO:0061024	membrane organization
# Gene3D	2.60.120.200	-; 2.
# Gene3D	4.10.740.10	-; 1.
# Genevisible	Q14393	HS
# HGNC	HGNC:4168	GAS6
# INTERACTION	GAS6_HUMAN	P30530 AXL; NbExp=8; IntAct=EBI-2802811, EBI-2850927; 
# IntAct	Q14393	13
# InterPro	IPR000152	EGF-type_Asp/Asn_hydroxyl_site
# InterPro	IPR000294	GLA_domain
# InterPro	IPR000742	EGF-like_dom
# InterPro	IPR001791	Laminin_G
# InterPro	IPR001881	EGF-like_Ca-bd_dom
# InterPro	IPR009030	Growth_fac_rcpt_
# InterPro	IPR013032	EGF-like_CS
# InterPro	IPR013320	ConA-like_dom
# InterPro	IPR017857	Coagulation_fac_subgr_Gla_dom
# InterPro	IPR018097	EGF_Ca-bd_CS
# InterPro	IPR026823	cEGF
# KEGG_Brite	ko04052	Cytokines
# MIM	600441	gene
# Organism	GAS6_HUMAN	Homo sapiens (Human)
# PDB	1H30	X-ray; 2.20 A; A=261-721
# PDB	2C5D	X-ray; 3.30 A; A/B=261-721
# PDB	4RA0	X-ray; 3.07 A; A/B=322-721
# PIR	B48089	B48089
# PRINTS	PR00001	GLABLOOD
# PROSITE	PS00010	ASX_HYDROXYL; 4
# PROSITE	PS00011	GLA_1
# PROSITE	PS00022	EGF_1
# PROSITE	PS01186	EGF_2; 3
# PROSITE	PS01187	EGF_CA; 3
# PROSITE	PS50025	LAM_G_DOMAIN; 2
# PROSITE	PS50026	EGF_3; 4
# PROSITE	PS50998	GLA_2
# PTM	GAS6_HUMAN	Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium. {ECO 0000255|PROSITE-ProRule PRU00463}. 
# PTM	GAS6_HUMAN	Isoform 1 is proteolytically processed after secretion to yield a N-terminal 36 kDa protein and a C-terminal 50 kDa protein including the laminin G-like domains which activates AXL. {ECO 0000269|PubMed 9326369}. 
# Pfam	PF00054	Laminin_G_1
# Pfam	PF00594	Gla
# Pfam	PF02210	Laminin_G_2
# Pfam	PF07645	EGF_CA
# Pfam	PF12661	hEGF; 2
# Pfam	PF12662	cEGF
# Proteomes	UP000005640	Chromosome 13
# Reactome	R-HSA-114608	Platelet degranulation
# Reactome	R-HSA-159740	Gamma-carboxylation of protein precursors
# Reactome	R-HSA-159763	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
# Reactome	R-HSA-159782	Removal of aminoterminal propeptides from gamma-carboxylated proteins
# Reactome	R-HSA-202733	Cell surface interactions at the vascular wall
# RecName	GAS6_HUMAN	Growth arrest-specific protein 6
# RefSeq	NP_000811	NM_000820.3. [Q14393-2]
# SIMILARITY	Contains 1 Gla (gamma-carboxy-glutamate) domain. {ECO:0000255|PROSITE-ProRule	PRU00463}. 
# SIMILARITY	Contains 2 laminin G-like domains. {ECO:0000255|PROSITE-ProRule	PRU00122}. 
# SIMILARITY	Contains 4 EGF-like domains. {ECO:0000255|PROSITE- ProRule	PRU00076}. 
# SMART	SM00069	GLA
# SMART	SM00179	EGF_CA; 4
# SMART	SM00181	EGF; 4
# SMART	SM00282	LamG; 2
# SUBCELLULAR LOCATION	GAS6_HUMAN	Secreted {ECO 0000269|PubMed 9326369}. 
# SUBUNIT	Heterodimer and heterotetramer with AXL. {ECO:0000269|PubMed	16362042}. 
# SUPFAM	SSF49899	SSF49899; 3
# SUPFAM	SSF57184	SSF57184
# SUPFAM	SSF57630	SSF57630
# TISSUE SPECIFICITY	GAS6_HUMAN	Plasma. Isoform 1 and isoform 2 are widely expressed. Isoform 1 is the predominant form in spleen. {ECO 0000269|PubMed 8336730, ECO 0000269|PubMed 9326368}. 
# UCSC	uc001vud	human. [Q14393-1]
# WEB RESOURCE	GAS6_HUMAN	Name=SeattleSNPs; URL="http //pga.gs.washington.edu/data/gas6/";
BLAST	swissprot:GAS6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GAS6_HUMAN
BioCyc	ZFISH:G66-32537-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32537-MONOMER
COXPRESdb	2621	http://coxpresdb.jp/data/gene/2621.shtml
CleanEx	HS_GAS6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GAS6
DOI	10.1002/humu.20025	http://dx.doi.org/10.1002/humu.20025
DOI	10.1016/0092-8674(95)90520-0	http://dx.doi.org/10.1016/0092-8674(95)90520-0
DOI	10.1016/S0014-5793(97)01093-4	http://dx.doi.org/10.1016/S0014-5793(97)01093-4
DOI	10.1016/S0014-5793(97)01094-6	http://dx.doi.org/10.1016/S0014-5793(97)01094-6
DOI	10.1016/j.cell.2015.05.028	http://dx.doi.org/10.1016/j.cell.2015.05.028
DOI	10.1016/j.chom.2011.03.012	http://dx.doi.org/10.1016/j.chom.2011.03.012
DOI	10.1016/j.chom.2012.08.009	http://dx.doi.org/10.1016/j.chom.2012.08.009
DOI	10.1038/373623a0	http://dx.doi.org/10.1038/373623a0
DOI	10.1038/nature02379	http://dx.doi.org/10.1038/nature02379
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.emboj.7600912	http://dx.doi.org/10.1038/sj.emboj.7600912
DOI	10.1074/jbc.271.16.9785	http://dx.doi.org/10.1074/jbc.271.16.9785
DOI	10.1074/jbc.271.47.30022	http://dx.doi.org/10.1074/jbc.271.47.30022
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1128/JVI.01157-06	http://dx.doi.org/10.1128/JVI.01157-06
DOI	10.1128/MCB.13.8.4976	http://dx.doi.org/10.1128/MCB.13.8.4976
DOI	10.1161/01.RES.0000036753.50601.E9	http://dx.doi.org/10.1161/01.RES.0000036753.50601.E9
DOI	10.1182/blood-2008-05-157073	http://dx.doi.org/10.1182/blood-2008-05-157073
EMBL	AK092028	http://www.ebi.ac.uk/ena/data/view/AK092028
EMBL	AK122969	http://www.ebi.ac.uk/ena/data/view/AK122969
EMBL	AK126533	http://www.ebi.ac.uk/ena/data/view/AK126533
EMBL	AK290803	http://www.ebi.ac.uk/ena/data/view/AK290803
EMBL	AY170372	http://www.ebi.ac.uk/ena/data/view/AY170372
EMBL	AY256830	http://www.ebi.ac.uk/ena/data/view/AY256830
EMBL	AY256831	http://www.ebi.ac.uk/ena/data/view/AY256831
EMBL	AY256832	http://www.ebi.ac.uk/ena/data/view/AY256832
EMBL	AY256833	http://www.ebi.ac.uk/ena/data/view/AY256833
EMBL	AY256834	http://www.ebi.ac.uk/ena/data/view/AY256834
EMBL	AY256835	http://www.ebi.ac.uk/ena/data/view/AY256835
EMBL	AY256836	http://www.ebi.ac.uk/ena/data/view/AY256836
EMBL	AY256837	http://www.ebi.ac.uk/ena/data/view/AY256837
EMBL	AY256838	http://www.ebi.ac.uk/ena/data/view/AY256838
EMBL	AY256839	http://www.ebi.ac.uk/ena/data/view/AY256839
EMBL	AY256840	http://www.ebi.ac.uk/ena/data/view/AY256840
EMBL	AY256841	http://www.ebi.ac.uk/ena/data/view/AY256841
EMBL	AY256842	http://www.ebi.ac.uk/ena/data/view/AY256842
EMBL	AY256843	http://www.ebi.ac.uk/ena/data/view/AY256843
EMBL	BC038984	http://www.ebi.ac.uk/ena/data/view/BC038984
EMBL	BK001240	http://www.ebi.ac.uk/ena/data/view/BK001240
EMBL	BX072579	http://www.ebi.ac.uk/ena/data/view/BX072579
EMBL	EF631974	http://www.ebi.ac.uk/ena/data/view/EF631974
EMBL	L13720	http://www.ebi.ac.uk/ena/data/view/L13720
Ensembl	ENST00000327773	http://www.ensembl.org/id/ENST00000327773
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005576	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576
GO_component	GO:0005615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005615
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005788	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005788
GO_component	GO:0005796	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005796
GO_component	GO:0031093	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031093
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0001786	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001786
GO_function	GO:0005102	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005102
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0030296	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030296
GO_function	GO:0030971	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030971
GO_function	GO:0043027	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043027
GO_function	GO:0048018	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048018
GO_function	GO:0060090	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060090
GO_process	GO:0001764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001764
GO_process	GO:0001934	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001934
GO_process	GO:0001961	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001961
GO_process	GO:0002576	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002576
GO_process	GO:0003104	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003104
GO_process	GO:0006465	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006465
GO_process	GO:0006468	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006468
GO_process	GO:0006888	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006888
GO_process	GO:0006909	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006909
GO_process	GO:0007050	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007050
GO_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007167
GO_process	GO:0008283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008283
GO_process	GO:0009267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009267
GO_process	GO:0010628	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010628
GO_process	GO:0010804	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010804
GO_process	GO:0010934	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010934
GO_process	GO:0016477	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016477
GO_process	GO:0018105	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018105
GO_process	GO:0019064	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019064
GO_process	GO:0019079	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019079
GO_process	GO:0030168	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030168
GO_process	GO:0031100	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031100
GO_process	GO:0031589	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031589
GO_process	GO:0032008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032008
GO_process	GO:0032148	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032148
GO_process	GO:0032689	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032689
GO_process	GO:0032715	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032715
GO_process	GO:0032720	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032720
GO_process	GO:0032825	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032825
GO_process	GO:0033138	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033138
GO_process	GO:0033159	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033159
GO_process	GO:0035457	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035457
GO_process	GO:0035690	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035690
GO_process	GO:0035754	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035754
GO_process	GO:0040008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040008
GO_process	GO:0043066	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043066
GO_process	GO:0043154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043154
GO_process	GO:0043277	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043277
GO_process	GO:0043433	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043433
GO_process	GO:0043491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043491
GO_process	GO:0045860	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045860
GO_process	GO:0045892	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892
GO_process	GO:0046718	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046718
GO_process	GO:0046813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046813
GO_process	GO:0046827	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046827
GO_process	GO:0048146	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048146
GO_process	GO:0050711	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050711
GO_process	GO:0050766	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050766
GO_process	GO:0050900	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050900
GO_process	GO:0051897	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051897
GO_process	GO:0061098	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061098
GO_process	GO:0070168	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070168
GO_process	GO:0070374	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070374
GO_process	GO:0070527	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070527
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:0071307	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071307
GO_process	GO:0071333	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071333
GO_process	GO:0071363	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071363
GO_process	GO:0072661	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072661
GO_process	GO:0085029	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0085029
GO_process	GO:0097028	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097028
GO_process	GO:0097241	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097241
GO_process	GO:1900142	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900142
GO_process	GO:1900165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900165
GO_process	GO:2000270	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000270
GO_process	GO:2000352	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000352
GO_process	GO:2000510	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000510
GO_process	GO:2000533	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000533
GO_process	GO:2000669	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000669
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005576	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576
GOslim_component	GO:0005615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005615
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0030234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0006605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0008283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008283
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0022607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0030198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030198
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GOslim_process	GO:0051604	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
Gene3D	2.60.120.200	http://www.cathdb.info/version/latest/superfamily/2.60.120.200
Gene3D	4.10.740.10	http://www.cathdb.info/version/latest/superfamily/4.10.740.10
GeneCards	GAS6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GAS6
GeneID	2621	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2621
GeneTree	ENSGT00530000063339	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063339
HGNC	HGNC:4168	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4168
HOGENOM	HOG000065758	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000065758&db=HOGENOM6
HOVERGEN	HBG051702	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051702&db=HOVERGEN
HPA	HPA008275	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA008275
HPA	HPA056080	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA056080
InParanoid	Q14393	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q14393
IntAct	Q14393	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q14393*
InterPro	IPR000152	http://www.ebi.ac.uk/interpro/entry/IPR000152
InterPro	IPR000294	http://www.ebi.ac.uk/interpro/entry/IPR000294
InterPro	IPR000742	http://www.ebi.ac.uk/interpro/entry/IPR000742
InterPro	IPR001791	http://www.ebi.ac.uk/interpro/entry/IPR001791
InterPro	IPR001881	http://www.ebi.ac.uk/interpro/entry/IPR001881
InterPro	IPR009030	http://www.ebi.ac.uk/interpro/entry/IPR009030
InterPro	IPR013032	http://www.ebi.ac.uk/interpro/entry/IPR013032
InterPro	IPR013320	http://www.ebi.ac.uk/interpro/entry/IPR013320
InterPro	IPR017857	http://www.ebi.ac.uk/interpro/entry/IPR017857
InterPro	IPR018097	http://www.ebi.ac.uk/interpro/entry/IPR018097
InterPro	IPR026823	http://www.ebi.ac.uk/interpro/entry/IPR026823
Jabion	2621	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2621
KEGG_Brite	ko04052	http://www.genome.jp/dbget-bin/www_bget?ko04052
KEGG_Gene	hsa:2621	http://www.genome.jp/dbget-bin/www_bget?hsa:2621
KEGG_Orthology	KO:K05464	http://www.genome.jp/dbget-bin/www_bget?KO:K05464
MIM	600441	http://www.ncbi.nlm.nih.gov/omim/600441
MINT	MINT-2735698	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-2735698
OMA	PVIRLRF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PVIRLRF
OrthoDB	EOG091G034Z	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G034Z
PDB	1H30	http://www.ebi.ac.uk/pdbe-srv/view/entry/1H30
PDB	2C5D	http://www.ebi.ac.uk/pdbe-srv/view/entry/2C5D
PDB	4RA0	http://www.ebi.ac.uk/pdbe-srv/view/entry/4RA0
PDBsum	1H30	http://www.ebi.ac.uk/pdbsum/1H30
PDBsum	2C5D	http://www.ebi.ac.uk/pdbsum/2C5D
PDBsum	4RA0	http://www.ebi.ac.uk/pdbsum/4RA0
PRINTS	PR00001	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00001
PROSITE	PS00010	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00010
PROSITE	PS00011	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00011
PROSITE	PS00022	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00022
PROSITE	PS01186	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01186
PROSITE	PS01187	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01187
PROSITE	PS50025	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50025
PROSITE	PS50026	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50026
PROSITE	PS50998	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50998
PSORT	swissprot:GAS6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GAS6_HUMAN
PSORT-B	swissprot:GAS6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GAS6_HUMAN
PSORT2	swissprot:GAS6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GAS6_HUMAN
Pfam	PF00054	http://pfam.xfam.org/family/PF00054
Pfam	PF00594	http://pfam.xfam.org/family/PF00594
Pfam	PF02210	http://pfam.xfam.org/family/PF02210
Pfam	PF07645	http://pfam.xfam.org/family/PF07645
Pfam	PF12661	http://pfam.xfam.org/family/PF12661
Pfam	PF12662	http://pfam.xfam.org/family/PF12662
PharmGKB	PA28582	http://www.pharmgkb.org/do/serve?objId=PA28582&objCls=Gene
Phobius	swissprot:GAS6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GAS6_HUMAN
PhylomeDB	Q14393	http://phylomedb.org/?seqid=Q14393
ProteinModelPortal	Q14393	http://www.proteinmodelportal.org/query/uniprot/Q14393
PubMed	12364394	http://www.ncbi.nlm.nih.gov/pubmed/12364394
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15057823	http://www.ncbi.nlm.nih.gov/pubmed/15057823
PubMed	15108283	http://www.ncbi.nlm.nih.gov/pubmed/15108283
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16362042	http://www.ncbi.nlm.nih.gov/pubmed/16362042
PubMed	17005688	http://www.ncbi.nlm.nih.gov/pubmed/17005688
PubMed	18840707	http://www.ncbi.nlm.nih.gov/pubmed/18840707
PubMed	21501828	http://www.ncbi.nlm.nih.gov/pubmed/21501828
PubMed	23084921	http://www.ncbi.nlm.nih.gov/pubmed/23084921
PubMed	26091039	http://www.ncbi.nlm.nih.gov/pubmed/26091039
PubMed	7854420	http://www.ncbi.nlm.nih.gov/pubmed/7854420
PubMed	7867073	http://www.ncbi.nlm.nih.gov/pubmed/7867073
PubMed	8336730	http://www.ncbi.nlm.nih.gov/pubmed/8336730
PubMed	8621659	http://www.ncbi.nlm.nih.gov/pubmed/8621659
PubMed	8939948	http://www.ncbi.nlm.nih.gov/pubmed/8939948
PubMed	9326368	http://www.ncbi.nlm.nih.gov/pubmed/9326368
PubMed	9326369	http://www.ncbi.nlm.nih.gov/pubmed/9326369
Reactome	R-HSA-114608	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-114608
Reactome	R-HSA-159740	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-159740
Reactome	R-HSA-159763	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-159763
Reactome	R-HSA-159782	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-159782
Reactome	R-HSA-202733	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-202733
RefSeq	NP_000811	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000811
SMART	SM00069	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00069
SMART	SM00179	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00179
SMART	SM00181	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00181
SMART	SM00282	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00282
SMR	Q14393	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q14393
SUPFAM	SSF49899	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49899
SUPFAM	SSF57184	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF57184
SUPFAM	SSF57630	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF57630
UCSC	uc001vud	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001vud&org=rat
UniGene	Hs.646346	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.646346
UniProtKB	GAS6_HUMAN	http://www.uniprot.org/uniprot/GAS6_HUMAN
UniProtKB-AC	Q14393	http://www.uniprot.org/uniprot/Q14393
charge	swissprot:GAS6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GAS6_HUMAN
epestfind	swissprot:GAS6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GAS6_HUMAN
garnier	swissprot:GAS6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GAS6_HUMAN
helixturnhelix	swissprot:GAS6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GAS6_HUMAN
hmoment	swissprot:GAS6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GAS6_HUMAN
iep	swissprot:GAS6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GAS6_HUMAN
inforesidue	swissprot:GAS6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GAS6_HUMAN
neXtProt	NX_Q14393	http://www.nextprot.org/db/entry/NX_Q14393
octanol	swissprot:GAS6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GAS6_HUMAN
pepcoil	swissprot:GAS6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GAS6_HUMAN
pepdigest	swissprot:GAS6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GAS6_HUMAN
pepinfo	swissprot:GAS6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GAS6_HUMAN
pepnet	swissprot:GAS6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GAS6_HUMAN
pepstats	swissprot:GAS6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GAS6_HUMAN
pepwheel	swissprot:GAS6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GAS6_HUMAN
pepwindow	swissprot:GAS6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GAS6_HUMAN
sigcleave	swissprot:GAS6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GAS6_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNA5_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P22460-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=P22460-2; Sequence=VSP_037110; 
# AltName	KCNA5_HUMAN	HPCN1
# AltName	KCNA5_HUMAN	Voltage-gated potassium channel HK2
# AltName	KCNA5_HUMAN	Voltage-gated potassium channel subunit Kv1.5
# BioGrid	109943	55
# CCDS	CCDS8536	-. [P22460-1]
# DISEASE	KCNA5_HUMAN	Atrial fibrillation, familial, 7 (ATFB7) [MIM 612240]  A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. {ECO 0000269|PubMed 16772329}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	KCNA5_HUMAN	The amino terminus may be important in determining the rate of inactivation of the channel while the C-terminal PDZ- binding motif may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. 
# DOMAIN	KCNA5_HUMAN	The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. {ECO 0000250|UniProtKB P63142}. 
# DrugBank	DB06637	Dalfampridine
# Ensembl	ENST00000252321	ENSP00000252321; ENSG00000130037. [P22460-1]
# FUNCTION	KCNA5_HUMAN	Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed 12130714). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed 12130714). Homotetrameric channels display rapid activation and slow inactivation (PubMed 8505626, PubMed 12130714). May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation (PubMed 11524461). {ECO 0000269|PubMed 11524461, ECO 0000269|PubMed 12130714, ECO 0000269|PubMed 8505626}. 
# GO_component	GO:0005783	endoplasmic reticulum; IEA:Ensembl.
# GO_component	GO:0005794	Golgi apparatus; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IDA:BHF-UCL.
# GO_component	GO:0014704	intercalated disc; IDA:BHF-UCL.
# GO_component	GO:0030018	Z disc; IEA:Ensembl.
# GO_component	GO:0034705	potassium channel complex; IDA:UniProtKB.
# GO_component	GO:0045121	membrane raft; IDA:BHF-UCL.
# GO_component	GO:0046691	intracellular canaliculus; IEA:Ensembl.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IEA:Ensembl.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; IDA:UniProtKB.
# GO_function	GO:0015271	outward rectifier potassium channel activity; IDA:BHF-UCL.
# GO_function	GO:0019870	potassium channel inhibitor activity; IEA:Ensembl.
# GO_function	GO:0019901	protein kinase binding; IPI:BHF-UCL.
# GO_function	GO:0051393	alpha-actinin binding; IPI:BHF-UCL.
# GO_function	GO:0086087	voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization; IMP:BHF-UCL.
# GO_function	GO:0086089	voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization; IMP:BHF-UCL.
# GO_function	GO:0086090	voltage-gated potassium channel activity involved in SA node cell action potential repolarization; IMP:BHF-UCL.
# GO_function	GO:0097110	scaffold protein binding; IPI:BHF-UCL.
# GO_process	GO:0001666	response to hypoxia; IEA:Ensembl.
# GO_process	GO:0006813	potassium ion transport; IDA:MGI.
# GO_process	GO:0007219	Notch signaling pathway; IEA:Ensembl.
# GO_process	GO:0009612	response to mechanical stimulus; IEA:Ensembl.
# GO_process	GO:0010033	response to organic substance; IEA:Ensembl.
# GO_process	GO:0019229	regulation of vasoconstriction; IEA:Ensembl.
# GO_process	GO:0042391	regulation of membrane potential; IDA:BHF-UCL.
# GO_process	GO:0042542	response to hydrogen peroxide; IEA:Ensembl.
# GO_process	GO:0043266	regulation of potassium ion transport; IMP:BHF-UCL.
# GO_process	GO:0043267	negative regulation of potassium ion transport; IEA:Ensembl.
# GO_process	GO:0050796	regulation of insulin secretion; TAS:BHF-UCL.
# GO_process	GO:0051260	protein homooligomerization; IEA:InterPro.
# GO_process	GO:0051481	negative regulation of cytosolic calcium ion concentration; IEA:Ensembl.
# GO_process	GO:0055075	potassium ion homeostasis; IEA:Ensembl.
# GO_process	GO:0055093	response to hyperoxia; IEA:Ensembl.
# GO_process	GO:0060081	membrane hyperpolarization; IMP:BHF-UCL.
# GO_process	GO:0060372	regulation of atrial cardiac muscle cell membrane repolarization; IMP:BHF-UCL.
# GO_process	GO:0071435	potassium ion export; IDA:BHF-UCL.
# GO_process	GO:0071805	potassium ion transmembrane transport; IDA:UniProtKB.
# GO_process	GO:0086014	atrial cardiac muscle cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086050	membrane repolarization during bundle of His cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086052	membrane repolarization during SA node cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086091	regulation of heart rate by cardiac conduction; IMP:BHF-UCL.
# GO_process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle; IEA:Ensembl.
# GO_process	GO:2000288	positive regulation of myoblast proliferation; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008092	cytoskeletal protein binding
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0003013	circulatory system process
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.350	-; 1.
# Genevisible	P22460	HS
# HGNC	HGNC:6224	KCNA5
# INTERACTION	KCNA5_HUMAN	P35609 ACTN2; NbExp=6; IntAct=EBI-6426121, EBI-77797; 
# IntAct	P22460	2
# InterPro	IPR000210	BTB/POZ_dom
# InterPro	IPR003131	T1-type_BTB
# InterPro	IPR003968	K_chnl_volt-dep_Kv
# InterPro	IPR003972	K_chnl_volt-dep_Kv1
# InterPro	IPR004052	K_chnl_volt-dep_Kv1.5
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR011333	SKP1/BTB/POZ
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko04040	Ion channels
# KEGG_Disease	H00731	[Cardiovascular disease] Atrial fibrillation
# MIM	176267	gene
# MIM	612240	phenotype
# Organism	KCNA5_HUMAN	Homo sapiens (Human)
# Orphanet	334	Familial atrial fibrillation
# PANTHER	PTHR11537	PTHR11537; 2
# PANTHER	PTHR11537:SF25	PTHR11537:SF25; 2
# PIR	A56031	A56031
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01491	KVCHANNEL
# PRINTS	PR01496	SHAKERCHANEL
# PRINTS	PR01512	KV15CHANNEL
# PTM	KCNA5_HUMAN	Sumoylated on Lys-221, and Lys-536, preferentially with SUMO3. Sumoylation regulates the voltage sensitivity of the channel. {ECO 0000269|PubMed 17261810}. 
# Pfam	PF00520	Ion_trans
# Pfam	PF02214	BTB_2
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# RecName	KCNA5_HUMAN	Potassium voltage-gated channel subfamily A member 5
# RefSeq	NP_002225	NM_002234.3. [P22460-1]
# SEQUENCE CAUTION	Sequence=AAA60146.1; Type=Frameshift; Positions=579; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily. {ECO	0000305}. 
# SMART	SM00225	BTB
# SUBCELLULAR LOCATION	KCNA5_HUMAN	Cell membrane {ECO 0000269|PubMed 12130714, ECO 0000269|PubMed 8505626}; Multi-pass membrane protein {ECO 0000305}. 
# SUBUNIT	KCNA5_HUMAN	Homotetramer and heterotetramer of potassium channel proteins. Interacts with DLG1, which enhances channel currents. Forms a ternary complex with DLG1 and CAV3 (By similarity). Interacts with KCNAB1 (PubMed 12130714). Interacts with UBE2I (PubMed 17261810). {ECO 0000250|UniProtKB P19024, ECO 0000269|PubMed 11524461, ECO 0000269|PubMed 12130714, ECO 0000269|PubMed 16466689, ECO 0000269|PubMed 17261810, ECO 0000269|PubMed 8505626}. 
# SUPFAM	SSF54695	SSF54695
# TCDB	1.A.1.2	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	KCNA5_HUMAN	Pancreatic islets and insulinoma. 
# UCSC	uc001qni	human. [P22460-1]
# eggNOG	COG1226	LUCA
# eggNOG	KOG1545	Eukaryota
BLAST	swissprot:KCNA5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNA5_HUMAN
BioCyc	ZFISH:ENSG00000130037-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000130037-MONOMER
COXPRESdb	3741	http://coxpresdb.jp/data/gene/3741.shtml
CleanEx	HS_KCNA5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNA5
DIP	DIP-42010N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-42010N
DOI	10.1016/0888-7543(92)90302-9	http://dx.doi.org/10.1016/0888-7543(92)90302-9
DOI	10.1016/j.bbrc.2006.01.110	http://dx.doi.org/10.1016/j.bbrc.2006.01.110
DOI	10.1073/pnas.0606702104	http://dx.doi.org/10.1073/pnas.0606702104
DOI	10.1073/pnas.88.1.53	http://dx.doi.org/10.1073/pnas.88.1.53
DOI	10.1085/jgp.101.4.513	http://dx.doi.org/10.1085/jgp.101.4.513
DOI	10.1085/jgp.118.3.315	http://dx.doi.org/10.1085/jgp.118.3.315
DOI	10.1093/hmg/ddl143	http://dx.doi.org/10.1093/hmg/ddl143
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1124/jpet.102.033357	http://dx.doi.org/10.1124/jpet.102.033357
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DrugBank	DB06637	http://www.drugbank.ca/drugs/DB06637
EMBL	BC096357	http://www.ebi.ac.uk/ena/data/view/BC096357
EMBL	BC096358	http://www.ebi.ac.uk/ena/data/view/BC096358
EMBL	BC099665	http://www.ebi.ac.uk/ena/data/view/BC099665
EMBL	BC099666	http://www.ebi.ac.uk/ena/data/view/BC099666
EMBL	M55513	http://www.ebi.ac.uk/ena/data/view/M55513
EMBL	M60451	http://www.ebi.ac.uk/ena/data/view/M60451
EMBL	M83254	http://www.ebi.ac.uk/ena/data/view/M83254
Ensembl	ENST00000252321	http://www.ensembl.org/id/ENST00000252321
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0014704	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014704
GO_component	GO:0030018	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030018
GO_component	GO:0034705	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034705
GO_component	GO:0045121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045121
GO_component	GO:0046691	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046691
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_function	GO:0015271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015271
GO_function	GO:0019870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019870
GO_function	GO:0019901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019901
GO_function	GO:0051393	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051393
GO_function	GO:0086087	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086087
GO_function	GO:0086089	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086089
GO_function	GO:0086090	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086090
GO_function	GO:0097110	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097110
GO_process	GO:0001666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001666
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0007219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007219
GO_process	GO:0009612	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009612
GO_process	GO:0010033	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010033
GO_process	GO:0019229	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019229
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0042542	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042542
GO_process	GO:0043266	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043266
GO_process	GO:0043267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043267
GO_process	GO:0050796	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050796
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:0051481	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051481
GO_process	GO:0055075	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055075
GO_process	GO:0055093	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055093
GO_process	GO:0060081	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060081
GO_process	GO:0060372	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060372
GO_process	GO:0071435	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071435
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GO_process	GO:0086014	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086014
GO_process	GO:0086050	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086050
GO_process	GO:0086052	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086052
GO_process	GO:0086091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086091
GO_process	GO:1900087	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900087
GO_process	GO:2000288	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000288
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0003013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003013
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	KCNA5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNA5
GeneID	3741	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3741
GeneTree	ENSGT00760000118846	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118846
HGNC	HGNC:6224	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6224
HOGENOM	HOG000231015	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231015&db=HOGENOM6
HOVERGEN	HBG052230	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052230&db=HOVERGEN
HPA	CAB022562	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB022562
HPA	HPA021516	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA021516
InParanoid	P22460	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P22460
IntAct	P22460	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P22460*
InterPro	IPR000210	http://www.ebi.ac.uk/interpro/entry/IPR000210
InterPro	IPR003131	http://www.ebi.ac.uk/interpro/entry/IPR003131
InterPro	IPR003968	http://www.ebi.ac.uk/interpro/entry/IPR003968
InterPro	IPR003972	http://www.ebi.ac.uk/interpro/entry/IPR003972
InterPro	IPR004052	http://www.ebi.ac.uk/interpro/entry/IPR004052
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR011333	http://www.ebi.ac.uk/interpro/entry/IPR011333
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	3741	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3741
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00731	http://www.genome.jp/dbget-bin/www_bget?H00731
KEGG_Gene	hsa:3741	http://www.genome.jp/dbget-bin/www_bget?hsa:3741
KEGG_Orthology	KO:K04878	http://www.genome.jp/dbget-bin/www_bget?KO:K04878
MIM	176267	http://www.ncbi.nlm.nih.gov/omim/176267
MIM	612240	http://www.ncbi.nlm.nih.gov/omim/612240
MINT	MINT-200758	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-200758
OMA	GGELQCP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GGELQCP
Orphanet	334	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=334
OrthoDB	EOG091G10NU	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G10NU
PANTHER	PTHR11537	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537
PANTHER	PTHR11537:SF25	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537:SF25
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01491	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01491
PRINTS	PR01496	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01496
PRINTS	PR01512	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01512
PSORT	swissprot:KCNA5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNA5_HUMAN
PSORT-B	swissprot:KCNA5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNA5_HUMAN
PSORT2	swissprot:KCNA5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNA5_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF02214	http://pfam.xfam.org/family/PF02214
PharmGKB	PA208	http://www.pharmgkb.org/do/serve?objId=PA208&objCls=Gene
Phobius	swissprot:KCNA5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNA5_HUMAN
PhylomeDB	P22460	http://phylomedb.org/?seqid=P22460
ProteinModelPortal	P22460	http://www.proteinmodelportal.org/query/uniprot/P22460
PubMed	11524461	http://www.ncbi.nlm.nih.gov/pubmed/11524461
PubMed	12130714	http://www.ncbi.nlm.nih.gov/pubmed/12130714
PubMed	1349297	http://www.ncbi.nlm.nih.gov/pubmed/1349297
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16466689	http://www.ncbi.nlm.nih.gov/pubmed/16466689
PubMed	16772329	http://www.ncbi.nlm.nih.gov/pubmed/16772329
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	17261810	http://www.ncbi.nlm.nih.gov/pubmed/17261810
PubMed	1986382	http://www.ncbi.nlm.nih.gov/pubmed/1986382
PubMed	2001794	http://www.ncbi.nlm.nih.gov/pubmed/2001794
PubMed	8505626	http://www.ncbi.nlm.nih.gov/pubmed/8505626
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
RefSeq	NP_002225	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002225
SMART	SM00225	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225
SMR	P22460	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P22460
STRING	9606.ENSP00000252321	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000252321&targetmode=cogs
SUPFAM	SSF54695	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54695
TCDB	1.A.1.2	http://www.tcdb.org/search/result.php?tc=1.A.1.2
UCSC	uc001qni	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001qni&org=rat
UniGene	Hs.150208	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.150208
UniGene	Hs.741439	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.741439
UniProtKB	KCNA5_HUMAN	http://www.uniprot.org/uniprot/KCNA5_HUMAN
UniProtKB-AC	P22460	http://www.uniprot.org/uniprot/P22460
charge	swissprot:KCNA5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNA5_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG1545	http://eggnogapi.embl.de/nog_data/html/tree/KOG1545
epestfind	swissprot:KCNA5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNA5_HUMAN
garnier	swissprot:KCNA5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNA5_HUMAN
helixturnhelix	swissprot:KCNA5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNA5_HUMAN
hmoment	swissprot:KCNA5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNA5_HUMAN
iep	swissprot:KCNA5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNA5_HUMAN
inforesidue	swissprot:KCNA5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNA5_HUMAN
neXtProt	NX_P22460	http://www.nextprot.org/db/entry/NX_P22460
octanol	swissprot:KCNA5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNA5_HUMAN
pepcoil	swissprot:KCNA5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNA5_HUMAN
pepdigest	swissprot:KCNA5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNA5_HUMAN
pepinfo	swissprot:KCNA5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNA5_HUMAN
pepnet	swissprot:KCNA5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNA5_HUMAN
pepstats	swissprot:KCNA5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNA5_HUMAN
pepwheel	swissprot:KCNA5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNA5_HUMAN
pepwindow	swissprot:KCNA5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNA5_HUMAN
sigcleave	swissprot:KCNA5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNA5_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	117723	20
# DOMAIN	TIM10_HUMAN	The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM10 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (Probable). {ECO 0000305}. 
# Ensembl	ENST00000257245	ENSP00000257245; ENSG00000134809
# Ensembl	ENST00000525158	ENSP00000433627; ENSG00000134809
# Ensembl	ENST00000525587	ENSP00000435678; ENSG00000134809
# FUNCTION	TIM10_HUMAN	Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. {ECO 0000269|PubMed 14726512}. 
# GO_component	GO:0005739	mitochondrion; IDA:HPA.
# GO_component	GO:0005743	mitochondrial inner membrane; IDA:BHF-UCL.
# GO_component	GO:0005744	mitochondrial inner membrane presequence translocase complex; TAS:UniProtKB.
# GO_component	GO:0005758	mitochondrial intermembrane space; TAS:BHF-UCL.
# GO_component	GO:0042719	mitochondrial intermembrane space protein transporter complex; IDA:BHF-UCL.
# GO_function	GO:0005215	transporter activity; IDA:BHF-UCL.
# GO_function	GO:0008270	zinc ion binding; TAS:UniProtKB.
# GO_function	GO:0008565	protein transporter activity; IBA:GO_Central.
# GO_function	GO:0042803	protein homodimerization activity; IPI:BHF-UCL.
# GO_function	GO:0051087	chaperone binding; IPI:BHF-UCL.
# GO_process	GO:0006626	protein targeting to mitochondrion; TAS:UniProtKB.
# GO_process	GO:0007605	sensory perception of sound; TAS:UniProtKB.
# GO_process	GO:0045039	protein import into mitochondrial inner membrane; IDA:BHF-UCL.
# GO_process	GO:0072321	chaperone-mediated protein transport; IDA:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006605	protein targeting
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007005	mitochondrion organization
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# GOslim_process	GO:0061024	membrane organization
# Gene3D	1.10.287.810	-; 1.
# Genevisible	P62072	HS
# HGNC	HGNC:11814	TIMM10
# INTERACTION	TIM10_HUMAN	Q9Y5J7 TIMM9; NbExp=4; IntAct=EBI-1200391, EBI-1200370; 
# IntAct	P62072	5
# InterPro	IPR004217	Tim10/DDP_fam_Znf
# InterPro	IPR027247	Tim10/Tim12
# MIM	602251	gene
# Organism	TIM10_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11038	PTHR11038
# PDB	2BSK	X-ray; 3.30 A; B/D/F=1-90
# Pfam	PF02953	zf-Tim10_DDP
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-1268020	Mitochondrial protein import
# RecName	TIM10_HUMAN	Mitochondrial import inner membrane translocase subunit Tim10
# RefSeq	NP_036588	NM_012456.2
# SIMILARITY	Belongs to the small Tim family. {ECO	0000305}.
# SUBCELLULAR LOCATION	TIM10_HUMAN	Mitochondrion inner membrane {ECO 0000269|PubMed 11489896, ECO 0000269|PubMed 14726512}; Peripheral membrane protein {ECO 0000269|PubMed 11489896, ECO 0000269|PubMed 14726512}; Intermembrane side {ECO 0000269|PubMed 11489896, ECO 0000269|PubMed 14726512}. 
# SUBUNIT	TIM10_HUMAN	Heterohexamer; composed of 3 copies of TIMM9 and 3 copies of TIMM10/TIM10A, named soluble 70 kDa complex. The complex forms a 6-bladed alpha-propeller structure and associates with the TIMM22 component of the TIM22 complex. Interacts with multi-pass transmembrane proteins in transit. Also forms a complex composed of TIMM9, TIMM10/TIM10A and FXC1/TIM10B. {ECO 0000269|PubMed 14726512, ECO 0000269|PubMed 16387659}. 
# SUPFAM	SSF144122	SSF144122
# TISSUE SPECIFICITY	TIM10_HUMAN	Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle. {ECO 0000269|PubMed 10552927, ECO 0000269|PubMed 10611480}. 
# UCSC	uc001nkm	human
# eggNOG	ENOG4112539	LUCA
# eggNOG	KOG3480	Eukaryota
BLAST	swissprot:TIM10_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TIM10_HUMAN
BioCyc	ZFISH:ENSG00000134809-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000134809-MONOMER
COXPRESdb	26519	http://coxpresdb.jp/data/gene/26519.shtml
CleanEx	HS_TIMM10	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TIMM10
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/geno.1999.5966	http://dx.doi.org/10.1006/geno.1999.5966
DOI	10.1016/S0014-5793(99)01665-8	http://dx.doi.org/10.1016/S0014-5793(99)01665-8
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.molcel.2005.11.010	http://dx.doi.org/10.1016/j.molcel.2005.11.010
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M105313200	http://dx.doi.org/10.1074/jbc.M105313200
DOI	10.1074/jbc.M312485200	http://dx.doi.org/10.1074/jbc.M312485200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF150089	http://www.ebi.ac.uk/ena/data/view/AF150089
EMBL	AF152354	http://www.ebi.ac.uk/ena/data/view/AF152354
EMBL	AK289751	http://www.ebi.ac.uk/ena/data/view/AK289751
EMBL	BC032133	http://www.ebi.ac.uk/ena/data/view/BC032133
EMBL	CH471076	http://www.ebi.ac.uk/ena/data/view/CH471076
Ensembl	ENST00000257245	http://www.ensembl.org/id/ENST00000257245
Ensembl	ENST00000525158	http://www.ensembl.org/id/ENST00000525158
Ensembl	ENST00000525587	http://www.ensembl.org/id/ENST00000525587
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005744	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005744
GO_component	GO:0005758	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005758
GO_component	GO:0042719	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042719
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0008270	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_function	GO:0051087	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051087
GO_process	GO:0006626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006626
GO_process	GO:0007605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007605
GO_process	GO:0045039	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045039
GO_process	GO:0072321	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072321
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007005
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
Gene3D	1.10.287.810	http://www.cathdb.info/version/latest/superfamily/1.10.287.810
GeneCards	TIMM10	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TIMM10
GeneID	26519	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26519
GeneTree	ENSGT00390000003068	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000003068
HGNC	HGNC:11814	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11814
HOGENOM	HOG000211421	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000211421&db=HOGENOM6
HOVERGEN	HBG055029	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG055029&db=HOVERGEN
HPA	HPA039946	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA039946
InParanoid	P62072	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P62072
IntAct	P62072	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P62072*
InterPro	IPR004217	http://www.ebi.ac.uk/interpro/entry/IPR004217
InterPro	IPR027247	http://www.ebi.ac.uk/interpro/entry/IPR027247
Jabion	26519	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=26519
KEGG_Gene	hsa:26519	http://www.genome.jp/dbget-bin/www_bget?hsa:26519
MIM	602251	http://www.ncbi.nlm.nih.gov/omim/602251
OMA	MDPMKAQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MDPMKAQ
OrthoDB	EOG091G15XZ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G15XZ
PANTHER	PTHR11038	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11038
PDB	2BSK	http://www.ebi.ac.uk/pdbe-srv/view/entry/2BSK
PDBsum	2BSK	http://www.ebi.ac.uk/pdbsum/2BSK
PSORT	swissprot:TIM10_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TIM10_HUMAN
PSORT-B	swissprot:TIM10_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TIM10_HUMAN
PSORT2	swissprot:TIM10_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TIM10_HUMAN
Pfam	PF02953	http://pfam.xfam.org/family/PF02953
PharmGKB	PA36521	http://www.pharmgkb.org/do/serve?objId=PA36521&objCls=Gene
Phobius	swissprot:TIM10_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TIM10_HUMAN
PhylomeDB	P62072	http://phylomedb.org/?seqid=P62072
ProteinModelPortal	P62072	http://www.proteinmodelportal.org/query/uniprot/P62072
PubMed	10552927	http://www.ncbi.nlm.nih.gov/pubmed/10552927
PubMed	10611480	http://www.ncbi.nlm.nih.gov/pubmed/10611480
PubMed	11489896	http://www.ncbi.nlm.nih.gov/pubmed/11489896
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	14726512	http://www.ncbi.nlm.nih.gov/pubmed/14726512
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16387659	http://www.ncbi.nlm.nih.gov/pubmed/16387659
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-1268020	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1268020
RefSeq	NP_036588	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_036588
SMR	P62072	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P62072
STRING	9606.ENSP00000257245	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000257245&targetmode=cogs
SUPFAM	SSF144122	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF144122
UCSC	uc001nkm	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001nkm&org=rat
UniGene	Hs.235750	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.235750
UniProtKB	TIM10_HUMAN	http://www.uniprot.org/uniprot/TIM10_HUMAN
UniProtKB-AC	P62072	http://www.uniprot.org/uniprot/P62072
charge	swissprot:TIM10_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TIM10_HUMAN
eggNOG	ENOG4112539	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4112539
eggNOG	KOG3480	http://eggnogapi.embl.de/nog_data/html/tree/KOG3480
epestfind	swissprot:TIM10_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TIM10_HUMAN
garnier	swissprot:TIM10_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TIM10_HUMAN
helixturnhelix	swissprot:TIM10_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TIM10_HUMAN
hmoment	swissprot:TIM10_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TIM10_HUMAN
iep	swissprot:TIM10_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TIM10_HUMAN
inforesidue	swissprot:TIM10_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TIM10_HUMAN
neXtProt	NX_P62072	http://www.nextprot.org/db/entry/NX_P62072
octanol	swissprot:TIM10_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TIM10_HUMAN
pepcoil	swissprot:TIM10_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TIM10_HUMAN
pepdigest	swissprot:TIM10_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TIM10_HUMAN
pepinfo	swissprot:TIM10_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TIM10_HUMAN
pepnet	swissprot:TIM10_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TIM10_HUMAN
pepstats	swissprot:TIM10_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TIM10_HUMAN
pepwheel	swissprot:TIM10_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TIM10_HUMAN
pepwindow	swissprot:TIM10_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TIM10_HUMAN
sigcleave	swissprot:TIM10_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TIM10_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S6A20_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=XT3; IsoId=Q9NP91-1; Sequence=Displayed; Name=2; Synonyms=XT3a; IsoId=Q9NP91-2; Sequence=VSP_050002; 
# AltName	S6A20_HUMAN	Sodium/imino-acid transporter 1
# AltName	S6A20_HUMAN	Solute carrier family 6 member 20
# AltName	S6A20_HUMAN	Transporter rB21A homolog
# BioGrid	120108	8
# CCDS	CCDS2730	-. [Q9NP91-2]
# CCDS	CCDS43077	-. [Q9NP91-1]
# ChiTaRS	SLC6A20	human
# DISEASE	S6A20_HUMAN	Hyperglycinuria (HG) [MIM 138500]  A condition characterized by excess of glycine in the urine. In some cases it is associated with renal colic and renal oxalate stones. {ECO 0000269|PubMed 19033659}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	S6A20_HUMAN	Iminoglycinuria (IG) [MIM 242600]  A disorder of renal tubular reabsorption of glycine and imino acids (proline and hydroxyproline), marked by excessive levels of all three substances in the urine. {ECO 0000269|PubMed 19033659}. Note=The disease is caused by mutations affecting the gene represented in this entry. Haploinsufficiency of SLC6A20 combined with deficiency of the neutral amino acid transporter SLC6A19 or partially inactivating mutations in SLC36A2, is responsible for iminoglycinuria. Additional polymorphisms and mutations in SLC6A18 can contribute to the IG phenotype in some families. 
# Ensembl	ENST00000353278	ENSP00000296133; ENSG00000163817. [Q9NP91-2]
# Ensembl	ENST00000358525	ENSP00000346298; ENSG00000163817. [Q9NP91-1]
# ExpressionAtlas	Q9NP91	baseline and differential
# FUNCTION	S6A20_HUMAN	Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N- methylated amino acids. Involved in the transport of glycine. {ECO 0000269|PubMed 15632147, ECO 0000269|PubMed 19033659}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016324	apical plasma membrane; ISS:UniProtKB.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; IDA:UniProtKB.
# GO_function	S6A20_HUMAN	GO 0005328 neurotransmitter sodium symporter activity; IEA InterPro.
# GO_function	S6A20_HUMAN	GO 0015375 glycine sodium symporter activity; IBA GO_Central.
# GO_process	GO:0006865	amino acid transport; IDA:UniProtKB.
# GO_process	GO:0015816	glycine transport; IMP:UniProtKB.
# GO_process	GO:0015824	proline transport; IMP:UniProtKB.
# GO_process	GO:0036233	glycine import; IBA:GO_Central.
# GO_process	GO:0060012	synaptic transmission, glycinergic; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# Genevisible	Q9NP91	HS
# HGNC	HGNC:30927	SLC6A20
# INTERACTION	S6A20_HUMAN	Q6UY14-3 ADAMTSL4; NbExp=3; IntAct=EBI-10311198, EBI-10173507; P60370 KRTAP10-5; NbExp=3; IntAct=EBI-10311198, EBI-10172150; P60409 KRTAP10-7; NbExp=3; IntAct=EBI-10311198, EBI-10172290; P60410 KRTAP10-8; NbExp=5; IntAct=EBI-10311198, EBI-10171774; P60411 KRTAP10-9; NbExp=3; IntAct=EBI-10311198, EBI-10172052; Q7Z3S9 NOTCH2NL; NbExp=5; IntAct=EBI-10311198, EBI-945833; 
# IntAct	Q9NP91	7
# InterPro	IPR000175	Na/ntran_symport
# InterPro	IPR002438	Na/ntran_symport_orphan
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00905	[Urinary system disease; Kidney disease; Inherited metabolic disease] Iminoglycinuria
# KEGG_Disease	H01304	[Kidney disease] Hyperglycinuria
# MIM	138500	phenotype
# MIM	242600	phenotype
# MIM	605616	gene
# Organism	S6A20_HUMAN	Homo sapiens (Human)
# Orphanet	42062	Iminoglycinuria
# PANTHER	PTHR11616	PTHR11616; 2
# PRINTS	PR00176	NANEUSMPORT
# PRINTS	PR01206	ORPHTRNSPORT
# PROSITE	PS00610	NA_NEUROTRAN_SYMP_1
# PROSITE	PS00754	NA_NEUROTRAN_SYMP_2
# PROSITE	PS50267	NA_NEUROTRAN_SYMP_3
# Pfam	PF00209	SNF
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-352230	Amino acid transport across the plasma membrane
# Reactome	R-HSA-442660	Na+/Cl- dependent neurotransmitter transporters
# RecName	S6A20_HUMAN	Sodium- and chloride-dependent transporter XTRP3
# RefSeq	NP_064593	NM_020208.3. [Q9NP91-1]
# RefSeq	NP_071800	NM_022405.3. [Q9NP91-2]
# SEQUENCE CAUTION	Sequence=AAL75944.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A20 subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S6A20_HUMAN	Apical cell membrane {ECO 0000250}; Multi- pass membrane protein {ECO 0000250}. Note=Located in the apical brush border membrane of kidney proximal tubule cells. {ECO 0000250}. 
# TCDB	2.A.22.6:the neurotransmitter	sodium symporter (nss) family
# TISSUE SPECIFICITY	S6A20_HUMAN	Kidney and small intestine. Expressed in the S3 segment of the proximal tubule. {ECO 0000269|PubMed 19033659, ECO 0000269|PubMed 9932288}. 
# UCSC	uc011bai	human. [Q9NP91-1]
# eggNOG	COG0733	LUCA
# eggNOG	KOG3659	Eukaryota
BLAST	swissprot:S6A20_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S6A20_HUMAN
BioCyc	ZFISH:ENSG00000163817-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000163817-MONOMER
COXPRESdb	54716	http://coxpresdb.jp/data/gene/54716.shtml
CleanEx	HS_SIT1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SIT1
CleanEx	HS_SLC6A20	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC6A20
DOI	10.1006/geno.2000.6498	http://dx.doi.org/10.1006/geno.2000.6498
DOI	10.1074/jbc.M413027200	http://dx.doi.org/10.1074/jbc.M413027200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1172/JCI36625	http://dx.doi.org/10.1172/JCI36625
EMBL	AF075260	http://www.ebi.ac.uk/ena/data/view/AF075260
EMBL	AF125107	http://www.ebi.ac.uk/ena/data/view/AF125107
EMBL	AJ276207	http://www.ebi.ac.uk/ena/data/view/AJ276207
EMBL	AJ276208	http://www.ebi.ac.uk/ena/data/view/AJ276208
EMBL	AJ289880	http://www.ebi.ac.uk/ena/data/view/AJ289880
EMBL	AL389979	http://www.ebi.ac.uk/ena/data/view/AL389979
EMBL	BC126197	http://www.ebi.ac.uk/ena/data/view/BC126197
EMBL	BC136431	http://www.ebi.ac.uk/ena/data/view/BC136431
EMBL	CH471055	http://www.ebi.ac.uk/ena/data/view/CH471055
Ensembl	ENST00000353278	http://www.ensembl.org/id/ENST00000353278
Ensembl	ENST00000358525	http://www.ensembl.org/id/ENST00000358525
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_function	GO:0005328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005328
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_function	GO:0015375	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015375
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GO_process	GO:0015816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015816
GO_process	GO:0015824	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015824
GO_process	GO:0036233	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036233
GO_process	GO:0060012	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060012
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GeneCards	SLC6A20	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC6A20
GeneID	54716	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54716
GeneTree	ENSGT00760000119044	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119044
HGNC	HGNC:30927	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:30927
HOGENOM	HOG000116406	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116406&db=HOGENOM6
HOVERGEN	HBG071421	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG071421&db=HOVERGEN
HPA	HPA029873	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA029873
InParanoid	Q9NP91	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NP91
IntAct	Q9NP91	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NP91*
InterPro	IPR000175	http://www.ebi.ac.uk/interpro/entry/IPR000175
InterPro	IPR002438	http://www.ebi.ac.uk/interpro/entry/IPR002438
Jabion	54716	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=54716
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00905	http://www.genome.jp/dbget-bin/www_bget?H00905
KEGG_Disease	H01304	http://www.genome.jp/dbget-bin/www_bget?H01304
KEGG_Gene	hsa:54716	http://www.genome.jp/dbget-bin/www_bget?hsa:54716
KEGG_Orthology	KO:K05048	http://www.genome.jp/dbget-bin/www_bget?KO:K05048
MIM	138500	http://www.ncbi.nlm.nih.gov/omim/138500
MIM	242600	http://www.ncbi.nlm.nih.gov/omim/242600
MIM	605616	http://www.ncbi.nlm.nih.gov/omim/605616
OMA	LVCLVNC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LVCLVNC
Orphanet	42062	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=42062
OrthoDB	EOG091G08PX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08PX
PANTHER	PTHR11616	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11616
PRINTS	PR00176	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00176
PRINTS	PR01206	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01206
PROSITE	PS00610	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00610
PROSITE	PS00754	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00754
PROSITE	PS50267	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50267
PSORT	swissprot:S6A20_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S6A20_HUMAN
PSORT-B	swissprot:S6A20_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S6A20_HUMAN
PSORT2	swissprot:S6A20_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S6A20_HUMAN
Pfam	PF00209	http://pfam.xfam.org/family/PF00209
PharmGKB	PA134865308	http://www.pharmgkb.org/do/serve?objId=PA134865308&objCls=Gene
Phobius	swissprot:S6A20_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S6A20_HUMAN
PhylomeDB	Q9NP91	http://phylomedb.org/?seqid=Q9NP91
ProteinModelPortal	Q9NP91	http://www.proteinmodelportal.org/query/uniprot/Q9NP91
PubMed	11352561	http://www.ncbi.nlm.nih.gov/pubmed/11352561
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15632147	http://www.ncbi.nlm.nih.gov/pubmed/15632147
PubMed	19033659	http://www.ncbi.nlm.nih.gov/pubmed/19033659
PubMed	9932288	http://www.ncbi.nlm.nih.gov/pubmed/9932288
Reactome	R-HSA-352230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-352230
Reactome	R-HSA-442660	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442660
RefSeq	NP_064593	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_064593
RefSeq	NP_071800	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_071800
STRING	9606.ENSP00000346298	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000346298&targetmode=cogs
TCDB	2.A.22.6	http://www.tcdb.org/search/result.php?tc=2.A.22.6
UCSC	uc011bai	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc011bai&org=rat
UniGene	Hs.413095	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.413095
UniProtKB	S6A20_HUMAN	http://www.uniprot.org/uniprot/S6A20_HUMAN
UniProtKB-AC	Q9NP91	http://www.uniprot.org/uniprot/Q9NP91
charge	swissprot:S6A20_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S6A20_HUMAN
eggNOG	COG0733	http://eggnogapi.embl.de/nog_data/html/tree/COG0733
eggNOG	KOG3659	http://eggnogapi.embl.de/nog_data/html/tree/KOG3659
epestfind	swissprot:S6A20_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S6A20_HUMAN
garnier	swissprot:S6A20_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S6A20_HUMAN
helixturnhelix	swissprot:S6A20_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S6A20_HUMAN
hmoment	swissprot:S6A20_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S6A20_HUMAN
iep	swissprot:S6A20_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S6A20_HUMAN
inforesidue	swissprot:S6A20_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S6A20_HUMAN
neXtProt	NX_Q9NP91	http://www.nextprot.org/db/entry/NX_Q9NP91
octanol	swissprot:S6A20_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S6A20_HUMAN
pepcoil	swissprot:S6A20_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S6A20_HUMAN
pepdigest	swissprot:S6A20_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S6A20_HUMAN
pepinfo	swissprot:S6A20_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S6A20_HUMAN
pepnet	swissprot:S6A20_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S6A20_HUMAN
pepstats	swissprot:S6A20_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S6A20_HUMAN
pepwheel	swissprot:S6A20_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S6A20_HUMAN
pepwindow	swissprot:S6A20_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S6A20_HUMAN
sigcleave	swissprot:S6A20_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S6A20_HUMAN
## Database	ID	URL or Descriptions
# AltName	QCR6_HUMAN	Complex III subunit 6
# AltName	QCR6_HUMAN	Complex III subunit VIII
# AltName	QCR6_HUMAN	Cytochrome c1 non-heme 11 kDa protein
# AltName	QCR6_HUMAN	Mitochondrial hinge protein
# AltName	QCR6_HUMAN	Ubiquinol-cytochrome c reductase complex 11 kDa protein
# BioGrid	113234	42
# ChiTaRS	UQCRH	human
# Ensembl	ENST00000311672	ENSP00000309565; ENSG00000173660
# ExpressionAtlas	P07919	baseline and differential
# FUNCTION	QCR6_HUMAN	This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. 
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0005746	mitochondrial respiratory chain; TAS:ProtInc.
# GO_function	GO:0008121	ubiquinol-cytochrome-c reductase activity; TAS:ProtInc.
# GO_process	GO:0006119	oxidative phosphorylation; TAS:ProtInc.
# GO_process	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c; TAS:Reactome.
# GO_process	GO:0009060	aerobic respiration; TAS:ProtInc.
# GO_process	GO:0055114	oxidation-reduction process; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# Gene3D	1.10.287.20	-; 1.
# Genevisible	P07919	HS
# HGNC	HGNC:12590	UQCRH
# INTERACTION	QCR6_HUMAN	Q96BM9 ARL8A; NbExp=5; IntAct=EBI-1224427, EBI-4401082; Q96H71 FAM189B; NbExp=3; IntAct=EBI-1224427, EBI-10195448; Q9Y225 RNF24; NbExp=3; IntAct=EBI-1224427, EBI-10195462; 
# IntAct	P07919	10
# InterPro	IPR003422	Cyt_b-c1_6
# InterPro	IPR023184	Ubol_cytC_Rdtase_hinge_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	613844	gene
# Organism	QCR6_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR15336	PTHR15336
# PIR	S00219	S00219
# PIRSF	PIRSF000019	Bc1_11K
# Pfam	PF02320	UCR_hinge
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-611105	Respiratory electron transport
# RecName	QCR6_HUMAN	Cytochrome b-c1 complex subunit 6, mitochondrial
# RefSeq	NP_005995	NM_006004.3
# SIMILARITY	Belongs to the UQCRH/QCR6 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	QCR6_HUMAN	Mitochondrion inner membrane {ECO 0000250|UniProtKB P00127}. 
# SUBUNIT	The bc1 complex contains 11 subunits	 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1). 
# SUPFAM	SSF81531	SSF81531
# UCSC	uc001cpp	human
# eggNOG	ENOG411247S	LUCA
# eggNOG	KOG4763	Eukaryota
BLAST	swissprot:QCR6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:QCR6_HUMAN
BioCyc	ZFISH:HS10708-MONOMER	http://biocyc.org/getid?id=ZFISH:HS10708-MONOMER
COXPRESdb	7388	http://coxpresdb.jp/data/gene/7388.shtml
CleanEx	HS_UQCRH	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_UQCRH
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/0014-5793(87)80573-2	http://dx.doi.org/10.1016/0014-5793(87)80573-2
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AK311967	http://www.ebi.ac.uk/ena/data/view/AK311967
EMBL	AL122001	http://www.ebi.ac.uk/ena/data/view/AL122001
EMBL	BC001426	http://www.ebi.ac.uk/ena/data/view/BC001426
EMBL	BC001934	http://www.ebi.ac.uk/ena/data/view/BC001934
EMBL	BC015177	http://www.ebi.ac.uk/ena/data/view/BC015177
EMBL	BC107703	http://www.ebi.ac.uk/ena/data/view/BC107703
EMBL	BT007070	http://www.ebi.ac.uk/ena/data/view/BT007070
EMBL	CH471059	http://www.ebi.ac.uk/ena/data/view/CH471059
EMBL	CH471059	http://www.ebi.ac.uk/ena/data/view/CH471059
EMBL	M36647	http://www.ebi.ac.uk/ena/data/view/M36647
EMBL	S61826	http://www.ebi.ac.uk/ena/data/view/S61826
EMBL	Y00764	http://www.ebi.ac.uk/ena/data/view/Y00764
Ensembl	ENST00000311672	http://www.ensembl.org/id/ENST00000311672
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005746	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005746
GO_function	GO:0008121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008121
GO_process	GO:0006119	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006119
GO_process	GO:0006122	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006122
GO_process	GO:0009060	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009060
GO_process	GO:0055114	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
Gene3D	1.10.287.20	http://www.cathdb.info/version/latest/superfamily/1.10.287.20
GeneCards	UQCRH	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=UQCRH
GeneID	7388	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7388
GeneTree	ENSGT00390000003860	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000003860
H-InvDB	HIX0023863	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0023863
HGNC	HGNC:12590	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:12590
HOGENOM	HOG000243673	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000243673&db=HOGENOM6
HOVERGEN	HBG001487	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG001487&db=HOVERGEN
HPA	HPA042574	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042574
InParanoid	P07919	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07919
IntAct	P07919	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07919*
InterPro	IPR003422	http://www.ebi.ac.uk/interpro/entry/IPR003422
InterPro	IPR023184	http://www.ebi.ac.uk/interpro/entry/IPR023184
Jabion	7388	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7388
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Gene	hsa:7388	http://www.genome.jp/dbget-bin/www_bget?hsa:7388
KEGG_Orthology	KO:K00416	http://www.genome.jp/dbget-bin/www_bget?KO:K00416
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	613844	http://www.ncbi.nlm.nih.gov/omim/613844
MINT	MINT-3006002	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3006002
OMA	SQTEEDC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SQTEEDC
OrthoDB	EOG091G13DH	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G13DH
PANTHER	PTHR15336	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15336
PSORT	swissprot:QCR6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:QCR6_HUMAN
PSORT-B	swissprot:QCR6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:QCR6_HUMAN
PSORT2	swissprot:QCR6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:QCR6_HUMAN
Pfam	PF02320	http://pfam.xfam.org/family/PF02320
PharmGKB	PA37220	http://www.pharmgkb.org/do/serve?objId=PA37220&objCls=Gene
Phobius	swissprot:QCR6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:QCR6_HUMAN
PhylomeDB	P07919	http://phylomedb.org/?seqid=P07919
ProteinModelPortal	P07919	http://www.proteinmodelportal.org/query/uniprot/P07919
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	2826252	http://www.ncbi.nlm.nih.gov/pubmed/2826252
PubMed	7684318	http://www.ncbi.nlm.nih.gov/pubmed/7684318
Reactome	R-HSA-611105	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-611105
RefSeq	NP_005995	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005995
SMR	P07919	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07919
STRING	9606.ENSP00000309565	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000309565&targetmode=cogs
SUPFAM	SSF81531	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81531
UCSC	uc001cpp	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001cpp&org=rat
UniGene	Hs.481571	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.481571
UniProtKB	QCR6_HUMAN	http://www.uniprot.org/uniprot/QCR6_HUMAN
UniProtKB-AC	P07919	http://www.uniprot.org/uniprot/P07919
charge	swissprot:QCR6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:QCR6_HUMAN
eggNOG	ENOG411247S	http://eggnogapi.embl.de/nog_data/html/tree/ENOG411247S
eggNOG	KOG4763	http://eggnogapi.embl.de/nog_data/html/tree/KOG4763
epestfind	swissprot:QCR6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:QCR6_HUMAN
garnier	swissprot:QCR6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:QCR6_HUMAN
helixturnhelix	swissprot:QCR6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:QCR6_HUMAN
hmoment	swissprot:QCR6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:QCR6_HUMAN
iep	swissprot:QCR6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:QCR6_HUMAN
inforesidue	swissprot:QCR6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:QCR6_HUMAN
neXtProt	NX_P07919	http://www.nextprot.org/db/entry/NX_P07919
octanol	swissprot:QCR6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:QCR6_HUMAN
pepcoil	swissprot:QCR6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:QCR6_HUMAN
pepdigest	swissprot:QCR6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:QCR6_HUMAN
pepinfo	swissprot:QCR6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:QCR6_HUMAN
pepnet	swissprot:QCR6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:QCR6_HUMAN
pepstats	swissprot:QCR6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:QCR6_HUMAN
pepwheel	swissprot:QCR6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:QCR6_HUMAN
pepwindow	swissprot:QCR6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:QCR6_HUMAN
sigcleave	swissprot:QCR6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:QCR6_HUMAN
## Database	ID	URL or Descriptions
# AltName	ABCBA_HUMAN	ATP-binding cassette transporter 10
# AltName	ABCBA_HUMAN	Mitochondrial ATP-binding cassette 2
# BRENDA	3.6.3.43	2681
# BioGrid	117020	25
# Ensembl	ENST00000344517	ENSP00000355637; ENSG00000135776
# FUNCTION	ABCBA_HUMAN	May mediate critical mitochondrial transport functions related to heme biosynthesis. {ECO 0000250}. 
# GO_component	GO:0005743	mitochondrial inner membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0032592	integral component of mitochondrial membrane; IDA:UniProtKB.
# GO_function	GO:0005215	transporter activity; NAS:UniProtKB.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; IBA:GO_Central.
# GO_process	GO:0006810	transport; NAS:UniProtKB.
# GO_process	GO:0055085	transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 1.
# Genevisible	Q9NRK6	HS
# HGNC	HGNC:41	ABCB10
# IntAct	Q9NRK6	2
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR011527	ABC1_TM_dom
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR027417	P-loop_NTPase
# InterPro	IPR030260	ABCB10
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko02010	ABC transporters
# MIM	605454	gene
# Organism	ABCBA_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR24221:SF121	PTHR24221:SF121
# PDB	3ZDQ	X-ray; 2.85 A; A=152-738
# PDB	4AYT	X-ray; 2.85 A; A=152-738
# PDB	4AYW	X-ray; 3.30 A; A=1-738
# PDB	4AYX	X-ray; 2.90 A; A=152-738
# PROSITE	PS00211	ABC_TRANSPORTER_1
# PROSITE	PS50893	ABC_TRANSPORTER_2
# PROSITE	PS50929	ABC_TM1F
# Pfam	PF00005	ABC_tran
# Pfam	PF00664	ABC_membrane
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-1369007	Mitochondrial ABC transporters
# RecName	ABCBA_HUMAN	ATP-binding cassette sub-family B member 10, mitochondrial
# RefSeq	NP_036221	NM_012089.2
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule	PRU00441}. 
# SIMILARITY	Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA
# SUBCELLULAR LOCATION	ABCBA_HUMAN	Mitochondrion inner membrane; Multi-pass membrane protein. 
# SUBUNIT	Homodimer or homooligomer. {ECO:0000269|PubMed	23716676}. 
# SUPFAM	SSF52540	SSF52540
# SUPFAM	SSF90123	SSF90123
# TCDB	3.A.1.201.17	the atp-binding cassette (abc) superfamily
# TISSUE SPECIFICITY	ABCBA_HUMAN	Ubiquitous. Highly expressed in bone marrow, expressed at intermediate to high levels in skeletal muscle, small intestine, thyroid, heart, brain, placenta, liver, pancreas, prostate, testis, ovary, leukocyte, stomach, spinal cord, lymph node, trachea and adrenal gland, and low levels are found in lung, kidney, spleen, thymus and colon. 
# UCSC	uc001htp	human
# WEB RESOURCE	ABCBA_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=Q9NRK6";
# eggNOG	COG1132	LUCA
# eggNOG	KOG0058	Eukaryota
BLAST	swissprot:ABCBA_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCBA_HUMAN
BioCyc	ZFISH:ENSG00000135776-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000135776-MONOMER
COXPRESdb	23456	http://coxpresdb.jp/data/gene/23456.shtml
CleanEx	HS_ABCB10	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCB10
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1007/BF00303254	http://dx.doi.org/10.1007/BF00303254
DOI	10.1007/s10038-002-8653-6	http://dx.doi.org/10.1007/s10038-002-8653-6
DOI	10.1016/S0014-5793(00)01823-8	http://dx.doi.org/10.1016/S0014-5793(00)01823-8
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1073/pnas.1217042110	http://dx.doi.org/10.1073/pnas.1217042110
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AB013380	http://www.ebi.ac.uk/ena/data/view/AB013380
EMBL	AF216833	http://www.ebi.ac.uk/ena/data/view/AF216833
EMBL	AL121990	http://www.ebi.ac.uk/ena/data/view/AL121990
EMBL	BC064930	http://www.ebi.ac.uk/ena/data/view/BC064930
EMBL	CH471098	http://www.ebi.ac.uk/ena/data/view/CH471098
EMBL	U18237	http://www.ebi.ac.uk/ena/data/view/U18237
Ensembl	ENST00000344517	http://www.ensembl.org/id/ENST00000344517
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0032592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032592
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCB10	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCB10
GeneID	23456	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23456
GeneTree	ENSGT00550000074497	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074497
H-InvDB	HIX0028493	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0028493
HGNC	HGNC:41	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:41
HOVERGEN	HBG008358	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG008358&db=HOVERGEN
HPA	CAB044063	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB044063
HPA	CAB044065	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB044065
HPA	HPA055175	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA055175
InParanoid	Q9NRK6	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NRK6
IntAct	Q9NRK6	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NRK6*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR011527	http://www.ebi.ac.uk/interpro/entry/IPR011527
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
InterPro	IPR030260	http://www.ebi.ac.uk/interpro/entry/IPR030260
Jabion	23456	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=23456
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:23456	http://www.genome.jp/dbget-bin/www_bget?hsa:23456
KEGG_Orthology	KO:K05657	http://www.genome.jp/dbget-bin/www_bget?KO:K05657
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
MIM	605454	http://www.ncbi.nlm.nih.gov/omim/605454
OMA	WAGDEAW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WAGDEAW
OrthoDB	EOG091G0HVA	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0HVA
PANTHER	PTHR24221:SF121	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24221:SF121
PDB	3ZDQ	http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZDQ
PDB	4AYT	http://www.ebi.ac.uk/pdbe-srv/view/entry/4AYT
PDB	4AYW	http://www.ebi.ac.uk/pdbe-srv/view/entry/4AYW
PDB	4AYX	http://www.ebi.ac.uk/pdbe-srv/view/entry/4AYX
PDBsum	3ZDQ	http://www.ebi.ac.uk/pdbsum/3ZDQ
PDBsum	4AYT	http://www.ebi.ac.uk/pdbsum/4AYT
PDBsum	4AYW	http://www.ebi.ac.uk/pdbsum/4AYW
PDBsum	4AYX	http://www.ebi.ac.uk/pdbsum/4AYX
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PROSITE	PS50929	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929
PSORT	swissprot:ABCBA_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCBA_HUMAN
PSORT-B	swissprot:ABCBA_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCBA_HUMAN
PSORT2	swissprot:ABCBA_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCBA_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF00664	http://pfam.xfam.org/family/PF00664
PharmGKB	PA24385	http://www.pharmgkb.org/do/serve?objId=PA24385&objCls=Gene
Phobius	swissprot:ABCBA_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCBA_HUMAN
PhylomeDB	Q9NRK6	http://phylomedb.org/?seqid=Q9NRK6
ProteinModelPortal	Q9NRK6	http://www.proteinmodelportal.org/query/uniprot/Q9NRK6
PubMed	10922475	http://www.ncbi.nlm.nih.gov/pubmed/10922475
PubMed	11829140	http://www.ncbi.nlm.nih.gov/pubmed/11829140
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23716676	http://www.ncbi.nlm.nih.gov/pubmed/23716676
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	7766993	http://www.ncbi.nlm.nih.gov/pubmed/7766993
Reactome	R-HSA-1369007	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1369007
RefSeq	NP_036221	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_036221
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	Q9NRK6	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9NRK6
STRING	9606.ENSP00000355637	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000355637&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
SUPFAM	SSF90123	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123
TCDB	3.A.1.201.17	http://www.tcdb.org/search/result.php?tc=3.A.1.201.17
UCSC	uc001htp	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001htp&org=rat
UniGene	Hs.17614	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.17614
UniProtKB	ABCBA_HUMAN	http://www.uniprot.org/uniprot/ABCBA_HUMAN
UniProtKB-AC	Q9NRK6	http://www.uniprot.org/uniprot/Q9NRK6
charge	swissprot:ABCBA_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCBA_HUMAN
eggNOG	COG1132	http://eggnogapi.embl.de/nog_data/html/tree/COG1132
eggNOG	KOG0058	http://eggnogapi.embl.de/nog_data/html/tree/KOG0058
epestfind	swissprot:ABCBA_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCBA_HUMAN
garnier	swissprot:ABCBA_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCBA_HUMAN
helixturnhelix	swissprot:ABCBA_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCBA_HUMAN
hmoment	swissprot:ABCBA_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCBA_HUMAN
iep	swissprot:ABCBA_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCBA_HUMAN
inforesidue	swissprot:ABCBA_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCBA_HUMAN
neXtProt	NX_Q9NRK6	http://www.nextprot.org/db/entry/NX_Q9NRK6
octanol	swissprot:ABCBA_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCBA_HUMAN
pepcoil	swissprot:ABCBA_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCBA_HUMAN
pepdigest	swissprot:ABCBA_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCBA_HUMAN
pepinfo	swissprot:ABCBA_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCBA_HUMAN
pepnet	swissprot:ABCBA_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCBA_HUMAN
pepstats	swissprot:ABCBA_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCBA_HUMAN
pepwheel	swissprot:ABCBA_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCBA_HUMAN
pepwindow	swissprot:ABCBA_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCBA_HUMAN
sigcleave	swissprot:ABCBA_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCBA_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CACB3_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=3A; IsoId=P54284-1; Sequence=Displayed; Name=2; Synonyms=3B; IsoId=P54284-2; Sequence=VSP_000634; Name=3; IsoId=P54284-3; Sequence=VSP_046708; Note=No experimental confirmation available.; Name=4; IsoId=P54284-4; Sequence=VSP_046709; Note=No experimental confirmation available.; Name=5; IsoId=P54284-5; Sequence=VSP_046710; Note=Gene prediction based on EST data.; 
# AltName	CACB3_HUMAN	Calcium channel voltage-dependent subunit beta 3
# BioGrid	107238	10
# CCDS	CCDS55821	-. [P54284-3]
# CCDS	CCDS55822	-. [P54284-4]
# CCDS	CCDS55823	-. [P54284-5]
# CCDS	CCDS8769	-. [P54284-1]
# ChiTaRS	CACNB3	human
# DrugBank	DB00393	Nimodipine
# DrugBank	DB00421	Spironolactone
# DrugBank	DB00661	Verapamil
# DrugBank	DB04855	Dronedarone
# Ensembl	ENST00000301050	ENSP00000301050; ENSG00000167535. [P54284-1]
# Ensembl	ENST00000536187	ENSP00000444160; ENSG00000167535. [P54284-4]
# Ensembl	ENST00000540990	ENSP00000445495; ENSG00000167535. [P54284-3]
# Ensembl	ENST00000547230	ENSP00000448304; ENSG00000167535. [P54284-5]
# ExpressionAtlas	P54284	baseline and differential
# FUNCTION	CACB3_HUMAN	The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. {ECO 0000250|UniProtKB P54287}. 
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005891	voltage-gated calcium channel complex; IDA:UniProtKB.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IEA:Ensembl.
# GO_component	GO:1990454	L-type voltage-gated calcium channel complex; ISS:UniProtKB.
# GO_function	GO:0005245	voltage-gated calcium channel activity; TAS:ProtInc.
# GO_function	GO:0005262	calcium channel activity; TAS:Reactome.
# GO_function	GO:0008331	high voltage-gated calcium channel activity; IBA:GO_Central.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006816	calcium ion transport; IDA:UniProtKB.
# GO_process	GO:0007268	chemical synaptic transmission; IBA:GO_Central.
# GO_process	GO:0007528	neuromuscular junction development; IBA:GO_Central.
# GO_process	GO:0050852	T cell receptor signaling pathway; IEA:Ensembl.
# GO_process	GO:0051899	membrane depolarization; TAS:Reactome.
# GO_process	GO:0060402	calcium ion transport into cytosol; ISS:BHF-UCL.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:0061577	calcium ion transmembrane transport via high voltage-gated calcium channel; ISS:UniProtKB.
# GO_process	GO:0072659	protein localization to plasma membrane; ISS:BHF-UCL.
# GO_process	GO:0098903	regulation of membrane repolarization during action potential; ISS:BHF-UCL.
# GO_process	GO:1901385	regulation of voltage-gated calcium channel activity; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007009	plasma membrane organization
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 1.
# Genevisible	P54284	HS
# HGNC	HGNC:1403	CACNB3
# INTERACTION	CACB3_HUMAN	Q5SQP8 CTBP2; NbExp=4; IntAct=EBI-1184651, EBI-11742664; 
# IntAct	P54284	8
# InterPro	IPR000584	VDCC_L_bsu
# InterPro	IPR001452	SH3_domain
# InterPro	IPR008079	VDCC_L_b3su
# InterPro	IPR008145	GK/Ca_channel_bsu
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04010	MAPK signaling pathway
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05410	Hypertrophic cardiomyopathy (HCM)
# KEGG_Pathway	ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
# KEGG_Pathway	ko05414	Dilated cardiomyopathy
# MIM	601958	gene
# Organism	CACB3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11824	PTHR11824
# PIR	S39315	S39315
# PIR	S39316	S39316
# PIR	S41211	S41211
# PRINTS	PR01626	LCACHANNELB
# PRINTS	PR01696	LCACHANNELB3
# Pfam	PF00625	Guanylate_kin
# Pfam	PF12052	VGCC_beta4Aa_N
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-112308	Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
# Reactome	R-HSA-400042	Adrenaline,noradrenaline inhibits insulin secretion
# Reactome	R-HSA-419037	NCAM1 interactions
# Reactome	R-HSA-422356	Regulation of insulin secretion
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# Reactome	R-HSA-5576893	Phase 2 - plateau phase
# Reactome	R-HSA-5576894	Phase 1 - inactivation of fast Na+ channels
# RecName	CACB3_HUMAN	Voltage-dependent L-type calcium channel subunit beta-3
# RefSeq	NP_000716	NM_000725.3. [P54284-1]
# RefSeq	NP_001193844	NM_001206915.1. [P54284-5]
# RefSeq	NP_001193845	NM_001206916.1. [P54284-4]
# RefSeq	NP_001193846	NM_001206917.1. [P54284-3]
# SIMILARITY	Belongs to the calcium channel beta subunit family. {ECO	0000305}. 
# SIMILARITY	Contains 1 SH3 domain. {ECO	0000305}.
# SMART	SM00072	GuKc
# SUBUNIT	CACB3_HUMAN	The L-type calcium channel is composed of four subunits  alpha-1, alpha-2, beta and gamma (By similarity). Interacts with CACNA2D4 (PubMed 12181424). Interacts with FASLG (PubMed 19807924). Interacts with CBARP; prevents the interaction of CACNB3 with the alpha subunit CACNA1C thereby negatively regulating the activity of the corresponding calcium channel (By similarity). {ECO 0000250|UniProtKB P54287, ECO 0000269|PubMed 12181424, ECO 0000269|PubMed 19807924}. 
# SUPFAM	SSF50044	SSF50044
# SUPFAM	SSF52540	SSF52540
# TCDB	8.A.22.1	the ca(2+) channel auxiliary subunit types 1-4 (cca-) family
# TISSUE SPECIFICITY	CACB3_HUMAN	Expressed mostly in brain, smooth muscle and ovary. 
# UCSC	uc001rsl	human. [P54284-1]
# eggNOG	ENOG410XRDI	LUCA
# eggNOG	KOG3812	Eukaryota
BLAST	swissprot:CACB3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CACB3_HUMAN
BioCyc	ZFISH:ENSG00000167535-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000167535-MONOMER
COXPRESdb	784	http://coxpresdb.jp/data/gene/784.shtml
CleanEx	HS_CACNB3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CACNB3
DIP	DIP-39138N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-39138N
DOI	10.1006/geno.1995.1048	http://dx.doi.org/10.1006/geno.1995.1048
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1432-1033.1994.tb18621.x	http://dx.doi.org/10.1111/j.1432-1033.1994.tb18621.x
DOI	10.1124/mol.62.3.485	http://dx.doi.org/10.1124/mol.62.3.485
DOI	10.1186/1471-2172-10-53	http://dx.doi.org/10.1186/1471-2172-10-53
DrugBank	DB00393	http://www.drugbank.ca/drugs/DB00393
DrugBank	DB00421	http://www.drugbank.ca/drugs/DB00421
DrugBank	DB00661	http://www.drugbank.ca/drugs/DB00661
DrugBank	DB04855	http://www.drugbank.ca/drugs/DB04855
EMBL	AC117498	http://www.ebi.ac.uk/ena/data/view/AC117498
EMBL	AK289709	http://www.ebi.ac.uk/ena/data/view/AK289709
EMBL	AK297639	http://www.ebi.ac.uk/ena/data/view/AK297639
EMBL	AK304537	http://www.ebi.ac.uk/ena/data/view/AK304537
EMBL	AK316323	http://www.ebi.ac.uk/ena/data/view/AK316323
EMBL	BC041811	http://www.ebi.ac.uk/ena/data/view/BC041811
EMBL	CH471111	http://www.ebi.ac.uk/ena/data/view/CH471111
EMBL	D43704	http://www.ebi.ac.uk/ena/data/view/D43704
EMBL	L27584	http://www.ebi.ac.uk/ena/data/view/L27584
EMBL	U07139	http://www.ebi.ac.uk/ena/data/view/U07139
EMBL	X76555	http://www.ebi.ac.uk/ena/data/view/X76555
EMBL	X76556	http://www.ebi.ac.uk/ena/data/view/X76556
Ensembl	ENST00000301050	http://www.ensembl.org/id/ENST00000301050
Ensembl	ENST00000536187	http://www.ensembl.org/id/ENST00000536187
Ensembl	ENST00000540990	http://www.ensembl.org/id/ENST00000540990
Ensembl	ENST00000547230	http://www.ensembl.org/id/ENST00000547230
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005891
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:1990454	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990454
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0008331	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008331
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007528	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007528
GO_process	GO:0050852	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050852
GO_process	GO:0051899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051899
GO_process	GO:0060402	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060402
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:0061577	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061577
GO_process	GO:0072659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072659
GO_process	GO:0098903	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098903
GO_process	GO:1901385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901385
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007009
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	CACNB3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CACNB3
GeneID	784	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=784
GeneTree	ENSGT00390000002740	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002740
HGNC	HGNC:1403	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1403
HOGENOM	HOG000230979	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230979&db=HOGENOM6
HOVERGEN	HBG050765	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050765&db=HOVERGEN
HPA	HPA059515	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA059515
InParanoid	P54284	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P54284
IntAct	P54284	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P54284*
InterPro	IPR000584	http://www.ebi.ac.uk/interpro/entry/IPR000584
InterPro	IPR001452	http://www.ebi.ac.uk/interpro/entry/IPR001452
InterPro	IPR008079	http://www.ebi.ac.uk/interpro/entry/IPR008079
InterPro	IPR008145	http://www.ebi.ac.uk/interpro/entry/IPR008145
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	784	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=784
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:784	http://www.genome.jp/dbget-bin/www_bget?hsa:784
KEGG_Orthology	KO:K04864	http://www.genome.jp/dbget-bin/www_bget?KO:K04864
KEGG_Pathway	ko04010	http://www.genome.jp/kegg-bin/show_pathway?ko04010
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05410	http://www.genome.jp/kegg-bin/show_pathway?ko05410
KEGG_Pathway	ko05412	http://www.genome.jp/kegg-bin/show_pathway?ko05412
KEGG_Pathway	ko05414	http://www.genome.jp/kegg-bin/show_pathway?ko05414
MIM	601958	http://www.ncbi.nlm.nih.gov/omim/601958
OMA	NERNWQR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NERNWQR
OrthoDB	EOG091G09C1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G09C1
PANTHER	PTHR11824	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11824
PRINTS	PR01626	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01626
PRINTS	PR01696	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01696
PSORT	swissprot:CACB3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CACB3_HUMAN
PSORT-B	swissprot:CACB3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CACB3_HUMAN
PSORT2	swissprot:CACB3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CACB3_HUMAN
Pfam	PF00625	http://pfam.xfam.org/family/PF00625
Pfam	PF12052	http://pfam.xfam.org/family/PF12052
PharmGKB	PA89	http://www.pharmgkb.org/do/serve?objId=PA89&objCls=Gene
Phobius	swissprot:CACB3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CACB3_HUMAN
PhylomeDB	P54284	http://phylomedb.org/?seqid=P54284
ProteinModelPortal	P54284	http://www.proteinmodelportal.org/query/uniprot/P54284
PubMed	12181424	http://www.ncbi.nlm.nih.gov/pubmed/12181424
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	19807924	http://www.ncbi.nlm.nih.gov/pubmed/19807924
PubMed	7557998	http://www.ncbi.nlm.nih.gov/pubmed/7557998
PubMed	8119293	http://www.ncbi.nlm.nih.gov/pubmed/8119293
Reactome	R-HSA-112308	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112308
Reactome	R-HSA-400042	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-400042
Reactome	R-HSA-419037	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-419037
Reactome	R-HSA-422356	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-422356
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
Reactome	R-HSA-5576893	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576893
Reactome	R-HSA-5576894	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576894
RefSeq	NP_000716	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000716
RefSeq	NP_001193844	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001193844
RefSeq	NP_001193845	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001193845
RefSeq	NP_001193846	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001193846
SMART	SM00072	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00072
SMR	P54284	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P54284
STRING	9606.ENSP00000301050	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000301050&targetmode=cogs
SUPFAM	SSF50044	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50044
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TCDB	8.A.22.1	http://www.tcdb.org/search/result.php?tc=8.A.22.1
UCSC	uc001rsl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001rsl&org=rat
UniGene	Hs.250712	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.250712
UniGene	Hs.737291	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.737291
UniProtKB	CACB3_HUMAN	http://www.uniprot.org/uniprot/CACB3_HUMAN
UniProtKB-AC	P54284	http://www.uniprot.org/uniprot/P54284
charge	swissprot:CACB3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CACB3_HUMAN
eggNOG	ENOG410XRDI	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRDI
eggNOG	KOG3812	http://eggnogapi.embl.de/nog_data/html/tree/KOG3812
epestfind	swissprot:CACB3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CACB3_HUMAN
garnier	swissprot:CACB3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CACB3_HUMAN
helixturnhelix	swissprot:CACB3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CACB3_HUMAN
hmoment	swissprot:CACB3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CACB3_HUMAN
iep	swissprot:CACB3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CACB3_HUMAN
inforesidue	swissprot:CACB3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CACB3_HUMAN
neXtProt	NX_P54284	http://www.nextprot.org/db/entry/NX_P54284
octanol	swissprot:CACB3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CACB3_HUMAN
pepcoil	swissprot:CACB3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CACB3_HUMAN
pepdigest	swissprot:CACB3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CACB3_HUMAN
pepinfo	swissprot:CACB3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CACB3_HUMAN
pepnet	swissprot:CACB3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CACB3_HUMAN
pepstats	swissprot:CACB3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CACB3_HUMAN
pepwheel	swissprot:CACB3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CACB3_HUMAN
pepwindow	swissprot:CACB3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CACB3_HUMAN
sigcleave	swissprot:CACB3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CACB3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SC5AC_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q1EHB4-1; Sequence=Displayed; Name=2; IsoId=Q1EHB4-2; Sequence=VSP_033994, VSP_033995; Note=No experimental confirmation available.; 
# AltName	SC5AC_HUMAN	Electroneutral sodium monocarboxylate cotransporter
# AltName	SC5AC_HUMAN	Low-affinity sodium-lactate cotransporter
# AltName	SC5AC_HUMAN	Solute carrier family 5 member 12
# CCDS	CCDS7860	-. [Q1EHB4-1]
# ENZYME REGULATION	SC5AC_HUMAN	Cotransport of monocarboxylates and nicotinate strongly inhibited by ibuprofen, fenoprofen and ketoprofen. 
# Ensembl	ENST00000280467	ENSP00000280467; ENSG00000148942. [Q1EHB4-2]
# Ensembl	ENST00000396005	ENSP00000379326; ENSG00000148942. [Q1EHB4-1]
# ExpressionAtlas	Q1EHB4	baseline and differential
# FUNCTION	SC5AC_HUMAN	Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D- hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina (By similarity). Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate (By similarity). {ECO 0000250, ECO 0000269|PubMed 17692818}. 
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016324	apical plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0015129	lactate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015293	symporter activity; IBA:GO_Central.
# GO_function	GO:0015355	secondary active monocarboxylate transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0006814	sodium ion transport; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q1EHB4	HS
# HGNC	HGNC:28750	SLC5A12
# InterPro	IPR001734	Na/solute_symporter
# KEGG_Brite	ko02001	Solute carrier family
# MIM	612455	gene
# Organism	SC5AC_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11819	PTHR11819
# PROSITE	PS50283	NA_SOLUT_SYMP_3
# Pfam	PF00474	SSF
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-427601	Multifunctional anion exchangers
# RecName	SC5AC_HUMAN	Sodium-coupled monocarboxylate transporter 2
# RefSeq	NP_848593	NM_178498.3. [Q1EHB4-1]
# SIMILARITY	Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	SC5AC_HUMAN	Apical cell membrane {ECO 0000269|PubMed 17692818}; Multi-pass membrane protein {ECO 0000269|PubMed 17692818}. Note=Detected at the brush border membrane of the kidney. Colocalizes with viementin in Mueller cells (By similarity). {ECO 0000250}. 
# TCDB	2.A.21.5:the solute	sodium symporter (sss) family
# TIGRFAMs	TIGR00813	sss
# UCSC	uc001mra	human. [Q1EHB4-1]
# eggNOG	COG0591	LUCA
# eggNOG	KOG2349	Eukaryota
BLAST	swissprot:SC5AC_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SC5AC_HUMAN
BioCyc	ZFISH:ENSG00000148942-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000148942-MONOMER
COXPRESdb	159963	http://coxpresdb.jp/data/gene/159963.shtml
CleanEx	HS_SLC5A12	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC5A12
DOI	10.1016/j.bbamem.2007.06.031	http://dx.doi.org/10.1016/j.bbamem.2007.06.031
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC083755	http://www.ebi.ac.uk/ena/data/view/AC083755
EMBL	AY299482	http://www.ebi.ac.uk/ena/data/view/AY299482
EMBL	BC049207	http://www.ebi.ac.uk/ena/data/view/BC049207
Ensembl	ENST00000280467	http://www.ensembl.org/id/ENST00000280467
Ensembl	ENST00000396005	http://www.ensembl.org/id/ENST00000396005
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0015129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015129
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_function	GO:0015355	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015355
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC5A12	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC5A12
GeneID	159963	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=159963
GeneTree	ENSGT00760000118955	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118955
H-InvDB	HIX0026178	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0026178
HGNC	HGNC:28750	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:28750
HOGENOM	HOG000261662	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261662&db=HOGENOM6
HOVERGEN	HBG057280	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG057280&db=HOVERGEN
HPA	HPA060904	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA060904
InParanoid	Q1EHB4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q1EHB4
InterPro	IPR001734	http://www.ebi.ac.uk/interpro/entry/IPR001734
Jabion	159963	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=159963
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:159963	http://www.genome.jp/dbget-bin/www_bget?hsa:159963
KEGG_Orthology	KO:K14388	http://www.genome.jp/dbget-bin/www_bget?KO:K14388
MIM	612455	http://www.ncbi.nlm.nih.gov/omim/612455
MINT	MINT-4723095	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4723095
OMA	AIADTWY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AIADTWY
OrthoDB	EOG091G07OC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07OC
PANTHER	PTHR11819	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11819
PROSITE	PS50283	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50283
PSORT	swissprot:SC5AC_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SC5AC_HUMAN
PSORT-B	swissprot:SC5AC_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SC5AC_HUMAN
PSORT2	swissprot:SC5AC_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SC5AC_HUMAN
Pfam	PF00474	http://pfam.xfam.org/family/PF00474
PharmGKB	PA134873929	http://www.pharmgkb.org/do/serve?objId=PA134873929&objCls=Gene
Phobius	swissprot:SC5AC_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SC5AC_HUMAN
PhylomeDB	Q1EHB4	http://phylomedb.org/?seqid=Q1EHB4
ProteinModelPortal	Q1EHB4	http://www.proteinmodelportal.org/query/uniprot/Q1EHB4
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	17692818	http://www.ncbi.nlm.nih.gov/pubmed/17692818
Reactome	R-HSA-427601	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-427601
RefSeq	NP_848593	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_848593
STRING	9606.ENSP00000379326	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000379326&targetmode=cogs
TCDB	2.A.21.5	http://www.tcdb.org/search/result.php?tc=2.A.21.5
TIGRFAMs	TIGR00813	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00813
UCSC	uc001mra	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001mra&org=rat
UniGene	Hs.148907	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.148907
UniProtKB	SC5AC_HUMAN	http://www.uniprot.org/uniprot/SC5AC_HUMAN
UniProtKB-AC	Q1EHB4	http://www.uniprot.org/uniprot/Q1EHB4
charge	swissprot:SC5AC_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SC5AC_HUMAN
eggNOG	COG0591	http://eggnogapi.embl.de/nog_data/html/tree/COG0591
eggNOG	KOG2349	http://eggnogapi.embl.de/nog_data/html/tree/KOG2349
epestfind	swissprot:SC5AC_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SC5AC_HUMAN
garnier	swissprot:SC5AC_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SC5AC_HUMAN
helixturnhelix	swissprot:SC5AC_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SC5AC_HUMAN
hmoment	swissprot:SC5AC_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SC5AC_HUMAN
iep	swissprot:SC5AC_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SC5AC_HUMAN
inforesidue	swissprot:SC5AC_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SC5AC_HUMAN
neXtProt	NX_Q1EHB4	http://www.nextprot.org/db/entry/NX_Q1EHB4
octanol	swissprot:SC5AC_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SC5AC_HUMAN
pepcoil	swissprot:SC5AC_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SC5AC_HUMAN
pepdigest	swissprot:SC5AC_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SC5AC_HUMAN
pepinfo	swissprot:SC5AC_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SC5AC_HUMAN
pepnet	swissprot:SC5AC_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SC5AC_HUMAN
pepstats	swissprot:SC5AC_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SC5AC_HUMAN
pepwheel	swissprot:SC5AC_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SC5AC_HUMAN
pepwindow	swissprot:SC5AC_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SC5AC_HUMAN
sigcleave	swissprot:SC5AC_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SC5AC_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S39AD_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96H72-1; Sequence=Displayed; Name=2; IsoId=Q96H72-2; Sequence=VSP_029819; 
# AltName	S39AD_HUMAN	LIV-1 subfamily of ZIP zinc transporter 9
# AltName	S39AD_HUMAN	Solute carrier family 39 member 13
# AltName	S39AD_HUMAN	Zrt- and Irt-like protein 13
# BioGrid	124808	4
# CCDS	CCDS44592	-. [Q96H72-1]
# CCDS	CCDS7934	-. [Q96H72-2]
# ChiTaRS	SLC39A13	human
# DISEASE	S39AD_HUMAN	Ehlers-Danlos syndrome-like spondylocheirodysplasia (SCD- EDS) [MIM 612350]  Spondylocheiro dysplastic form of Ehlers-Danlos syndrome. The syndrome consists of a generalized skeletal dysplasia involving mainly the spine (spondylo) and striking clinical abnormalities of the hands (cheiro) in addition to the EDS-like features. Clinical features included postnatal growth retardation, moderate short stature, protuberant eyes with bluish sclerae, hands with finely wrinkled palms, atrophy of the thenar muscles, and tapering fingers. Patients have thin, hyperelastic skin and hypermobile small joints consistent with an Ehlers- Danlos-like phenotype. Radiologic features included mild to moderate platyspondyly, mild to moderate osteopenia of the spine, small ileum, flat proximal femoral epiphyses, short, wide femoral necks, and broad metaphyses (elbows, knees, wrists, and interphalangeal joints). {ECO 0000269|PubMed 18513683}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000354884	ENSP00000346956; ENSG00000165915. [Q96H72-2]
# Ensembl	ENST00000362021	ENSP00000354689; ENSG00000165915. [Q96H72-1]
# ExpressionAtlas	Q96H72	baseline and differential
# FUNCTION	S39AD_HUMAN	Acts as a zinc-influx transporter. {ECO 0000269|PubMed 21917916}. 
# GO_component	GO:0005794	Golgi apparatus; IDA:BHF-UCL.
# GO_component	GO:0016021	integral component of membrane; IDA:BHF-UCL.
# GO_component	GO:0030173	integral component of Golgi membrane; IC:BHF-UCL.
# GO_component	GO:0048471	perinuclear region of cytoplasm; ISS:BHF-UCL.
# GO_function	GO:0005385	zinc ion transmembrane transporter activity; IDA:BHF-UCL.
# GO_function	GO:0042803	protein homodimerization activity; IPI:BHF-UCL.
# GO_process	GO:0006882	cellular zinc ion homeostasis; IDA:BHF-UCL.
# GO_process	GO:0061448	connective tissue development; IMP:BHF-UCL.
# GO_process	GO:0071577	zinc II ion transmembrane transport; IDA:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q96H72	HS
# HGNC	HGNC:20859	SLC39A13
# INTERACTION	S39AD_HUMAN	Q04864 REL; NbExp=3; IntAct=EBI-10287091, EBI-307352; P15884 TCF4; NbExp=3; IntAct=EBI-10287091, EBI-533224; 
# IntAct	Q96H72	3
# InterPro	IPR003689	ZIP
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H00802	[Inherited metabolic disease; Connective tissue disease] EDS-like spondylocheiro dysplasia (SCD-EDS)
# MIM	608735	gene
# MIM	612350	phenotype
# Organism	S39AD_HUMAN	Homo sapiens (Human)
# Orphanet	157965	Ehlers-Danlos syndrome, spondylocheirodysplastic type
# Pfam	PF02535	Zip; 2
# Proteomes	UP000005640	Chromosome 11
# RecName	S39AD_HUMAN	Zinc transporter ZIP13
# RefSeq	NP_001121697	NM_001128225.2
# RefSeq	NP_001317174	NM_001330245.1
# RefSeq	NP_689477	NM_152264.4
# RefSeq	XP_011518769	XM_011520467.1. [Q96H72-1]
# RefSeq	XP_011518770	XM_011520468.2. [Q96H72-1]
# RefSeq	XP_016874029	XM_017018540.1. [Q96H72-2]
# SEQUENCE CAUTION	Sequence=BAC05365.1; Type=Frameshift; Positions=314; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the ZIP transporter (TC 2.A.5) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S39AD_HUMAN	Golgi apparatus membrane {ECO 0000269|PubMed 21917916}; Multi-pass membrane protein {ECO 0000269|PubMed 21917916}. 
# SUBUNIT	Homodimer. {ECO:0000305|PubMed	21917916}. 
# TCDB	2.A.5.4.12	the zinc (zn(2+))-iron (fe(2+)) permease (zip) family
# UCSC	uc001nff	human. [Q96H72-1]
# eggNOG	COG0428	LUCA
# eggNOG	KOG2694	Eukaryota
BLAST	swissprot:S39AD_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S39AD_HUMAN
COXPRESdb	91252	http://coxpresdb.jp/data/gene/91252.shtml
CleanEx	HS_SLC39A13	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC39A13
DOI	10.1016/j.ajhg.2008.05.001	http://dx.doi.org/10.1016/j.ajhg.2008.05.001
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M111.256784	http://dx.doi.org/10.1074/jbc.M111.256784
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AC090559	http://www.ebi.ac.uk/ena/data/view/AC090559
EMBL	AK098651	http://www.ebi.ac.uk/ena/data/view/AK098651
EMBL	AL133581	http://www.ebi.ac.uk/ena/data/view/AL133581
EMBL	BC008853	http://www.ebi.ac.uk/ena/data/view/BC008853
EMBL	BC019016	http://www.ebi.ac.uk/ena/data/view/BC019016
EMBL	CH471064	http://www.ebi.ac.uk/ena/data/view/CH471064
EMBL	CH471064	http://www.ebi.ac.uk/ena/data/view/CH471064
EMBL	CH471064	http://www.ebi.ac.uk/ena/data/view/CH471064
EMBL	CH471064	http://www.ebi.ac.uk/ena/data/view/CH471064
EMBL	CH471064	http://www.ebi.ac.uk/ena/data/view/CH471064
EMBL	CH471064	http://www.ebi.ac.uk/ena/data/view/CH471064
Ensembl	ENST00000354884	http://www.ensembl.org/id/ENST00000354884
Ensembl	ENST00000362021	http://www.ensembl.org/id/ENST00000362021
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030173	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030173
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_function	GO:0005385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005385
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_process	GO:0006882	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006882
GO_process	GO:0061448	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061448
GO_process	GO:0071577	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071577
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC39A13	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC39A13
GeneID	91252	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=91252
GeneTree	ENSGT00760000119115	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119115
H-InvDB	HIX0009615	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0009615
HGNC	HGNC:20859	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20859
HOGENOM	HOG000185308	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000185308&db=HOGENOM6
HOVERGEN	HBG001037	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG001037&db=HOVERGEN
HPA	HPA043971	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA043971
InParanoid	Q96H72	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96H72
IntAct	Q96H72	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96H72*
InterPro	IPR003689	http://www.ebi.ac.uk/interpro/entry/IPR003689
Jabion	91252	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=91252
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00802	http://www.genome.jp/dbget-bin/www_bget?H00802
KEGG_Gene	hsa:91252	http://www.genome.jp/dbget-bin/www_bget?hsa:91252
KEGG_Orthology	KO:K14719	http://www.genome.jp/dbget-bin/www_bget?KO:K14719
MIM	608735	http://www.ncbi.nlm.nih.gov/omim/608735
MIM	612350	http://www.ncbi.nlm.nih.gov/omim/612350
OMA	EEDDPWH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EEDDPWH
Orphanet	157965	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=157965
OrthoDB	EOG091G0GD1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0GD1
PSORT	swissprot:S39AD_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S39AD_HUMAN
PSORT-B	swissprot:S39AD_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S39AD_HUMAN
PSORT2	swissprot:S39AD_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S39AD_HUMAN
Pfam	PF02535	http://pfam.xfam.org/family/PF02535
PharmGKB	PA134948414	http://www.pharmgkb.org/do/serve?objId=PA134948414&objCls=Gene
Phobius	swissprot:S39AD_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S39AD_HUMAN
PhylomeDB	Q96H72	http://phylomedb.org/?seqid=Q96H72
ProteinModelPortal	Q96H72	http://www.proteinmodelportal.org/query/uniprot/Q96H72
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18513683	http://www.ncbi.nlm.nih.gov/pubmed/18513683
PubMed	21917916	http://www.ncbi.nlm.nih.gov/pubmed/21917916
RefSeq	NP_001121697	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001121697
RefSeq	NP_001317174	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001317174
RefSeq	NP_689477	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_689477
RefSeq	XP_011518769	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011518769
RefSeq	XP_011518770	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011518770
RefSeq	XP_016874029	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016874029
STRING	9606.ENSP00000354689	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000354689&targetmode=cogs
TCDB	2.A.5.4.12	http://www.tcdb.org/search/result.php?tc=2.A.5.4.12
UCSC	uc001nff	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001nff&org=rat
UniGene	Hs.523664	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.523664
UniProtKB	S39AD_HUMAN	http://www.uniprot.org/uniprot/S39AD_HUMAN
UniProtKB-AC	Q96H72	http://www.uniprot.org/uniprot/Q96H72
charge	swissprot:S39AD_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S39AD_HUMAN
eggNOG	COG0428	http://eggnogapi.embl.de/nog_data/html/tree/COG0428
eggNOG	KOG2694	http://eggnogapi.embl.de/nog_data/html/tree/KOG2694
epestfind	swissprot:S39AD_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S39AD_HUMAN
garnier	swissprot:S39AD_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S39AD_HUMAN
helixturnhelix	swissprot:S39AD_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S39AD_HUMAN
hmoment	swissprot:S39AD_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S39AD_HUMAN
iep	swissprot:S39AD_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S39AD_HUMAN
inforesidue	swissprot:S39AD_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S39AD_HUMAN
neXtProt	NX_Q96H72	http://www.nextprot.org/db/entry/NX_Q96H72
octanol	swissprot:S39AD_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S39AD_HUMAN
pepcoil	swissprot:S39AD_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S39AD_HUMAN
pepdigest	swissprot:S39AD_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S39AD_HUMAN
pepinfo	swissprot:S39AD_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S39AD_HUMAN
pepnet	swissprot:S39AD_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S39AD_HUMAN
pepstats	swissprot:S39AD_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S39AD_HUMAN
pepwheel	swissprot:S39AD_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S39AD_HUMAN
pepwindow	swissprot:S39AD_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S39AD_HUMAN
sigcleave	swissprot:S39AD_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S39AD_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SC5AB_HUMAN	Event=Alternative splicing; Named isoforms=6; Name=1 {ECO 0000269|PubMed 12039040}; IsoId=Q8WWX8-1; Sequence=Displayed; Name=2 {ECO 0000269|PubMed 12039040}; IsoId=Q8WWX8-2; Sequence=VSP_052790; Name=3 {ECO 0000269|PubMed 15489334}; IsoId=Q8WWX8-3; Sequence=VSP_052789; Note=No experimental confirmation available. {ECO 0000305}; Name=4; IsoId=Q8WWX8-4; Sequence=VSP_033259; Note=No experimental confirmation available.; Name=5; IsoId=Q8WWX8-5; Sequence=VSP_045034, VSP_052790; Note=No experimental confirmation available.; Name=6; IsoId=Q8WWX8-6; Sequence=VSP_052789, VSP_045035, VSP_045036; Note=No experimental confirmation available.; 
# AltName	SC5AB_HUMAN	Sodium-dependent glucose cotransporter
# AltName	SC5AB_HUMAN	Sodium/glucose cotransporter KST1
# AltName	SC5AB_HUMAN	Sodium/myo-inositol transporter 2
# AltName	SC5AB_HUMAN	Solute carrier family 5 member 11
# BioGrid	125441	2
# CCDS	CCDS10625	-. [Q8WWX8-1]
# CCDS	CCDS58437	-. [Q8WWX8-2]
# CCDS	CCDS58438	-. [Q8WWX8-5]
# CCDS	CCDS58439	-. [Q8WWX8-3]
# CCDS	CCDS58440	-. [Q8WWX8-6]
# Ensembl	ENST00000347898	ENSP00000289932; ENSG00000158865. [Q8WWX8-1]
# Ensembl	ENST00000424767	ENSP00000416782; ENSG00000158865. [Q8WWX8-2]
# Ensembl	ENST00000449109	ENSP00000389606; ENSG00000158865. [Q8WWX8-6]
# Ensembl	ENST00000545376	ENSP00000441384; ENSG00000158865. [Q8WWX8-5]
# Ensembl	ENST00000565769	ENSP00000457179; ENSG00000158865. [Q8WWX8-3]
# Ensembl	ENST00000567758	ENSP00000454401; ENSG00000158865. [Q8WWX8-2]
# Ensembl	ENST00000568579	ENSP00000456234; ENSG00000158865. [Q8WWX8-5]
# Ensembl	ENST00000569071	ENSP00000456376; ENSG00000158865. [Q8WWX8-6]
# ExpressionAtlas	Q8WWX8	baseline and differential
# FUNCTION	SC5AB_HUMAN	Involved in the sodium-dependent cotransport of myo- inositol (MI) with a Na(+) MI stoichiometry of 2 1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D- xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney. {ECO 0000269|PubMed 15172003}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0015166	polyol transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015293	symporter activity; IBA:GO_Central.
# GO_process	GO:0006814	sodium ion transport; IEA:UniProtKB-KW.
# GO_process	GO:0006915	apoptotic process; IEA:UniProtKB-KW.
# GO_process	GO:0008643	carbohydrate transport; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008219	cell death
# Genevisible	Q8WWX8	HS
# HGNC	HGNC:23091	SLC5A11
# INTERACTION	SC5AB_HUMAN	Q8IYQ9 KPNA3; NbExp=3; IntAct=EBI-10277669, EBI-742146; 
# InterPro	IPR001734	Na/solute_symporter
# KEGG_Brite	ko02001	Solute carrier family
# MIM	610238	gene
# MISCELLANEOUS	SC5AB_HUMAN	Acts as an autoimmune modifier in systemic lupus erythematosus (SLE) as it is significantly associated with low complement component 4 (C4), anti-Smith antibody, serositis, and alopecia. 
# Organism	SC5AB_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11819	PTHR11819; 2
# PROSITE	PS50283	NA_SOLUT_SYMP_3
# Pfam	PF00474	SSF
# Proteomes	UP000005640	Chromosome 16
# Reactome	R-HSA-429593	Inositol transporters
# RecName	SC5AB_HUMAN	Sodium/myo-inositol cotransporter 2
# RefSeq	NP_001245340	NM_001258411.2. [Q8WWX8-2]
# RefSeq	NP_001245341	NM_001258412.2. [Q8WWX8-5]
# RefSeq	NP_001245342	NM_001258413.2. [Q8WWX8-3]
# RefSeq	NP_001245343	NM_001258414.1. [Q8WWX8-6]
# RefSeq	NP_443176	NM_052944.4. [Q8WWX8-1]
# RefSeq	XP_005255137	XM_005255080.2. [Q8WWX8-1]
# RefSeq	XP_016878389	XM_017022900.1. [Q8WWX8-1]
# RefSeq	XP_016878390	XM_017022901.1. [Q8WWX8-1]
# RefSeq	XP_016878391	XM_017022902.1. [Q8WWX8-1]
# RefSeq	XP_016878392	XM_017022903.1. [Q8WWX8-1]
# RefSeq	XP_016878394	XM_017022905.1. [Q8WWX8-2]
# RefSeq	XP_016878395	XM_017022906.1. [Q8WWX8-3]
# SIMILARITY	Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. {ECO	0000255}.
# SUBCELLULAR LOCATION	SC5AB_HUMAN	Membrane {ECO 0000250|UniProtKB Q28728}; Multi-pass membrane protein {ECO 0000250|UniProtKB Q28728}. 
# TCDB	2.A.21.3:the solute	sodium symporter (sss) family
# TIGRFAMs	TIGR00813	sss
# TISSUE SPECIFICITY	Highest expression in heart, skeletal muscle, kidney, liver and placenta. Weaker expression in brain, colon, spleen, lung and peripheral blood leukocytes. {ECO:0000269|PubMed	12039040}. 
# UCSC	uc002dms	human. [Q8WWX8-1]
# eggNOG	COG4146	LUCA
# eggNOG	ENOG410IP49	Eukaryota
BLAST	swissprot:SC5AB_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SC5AB_HUMAN
BioCyc	ZFISH:ENSG00000158865-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000158865-MONOMER
COXPRESdb	115584	http://coxpresdb.jp/data/gene/115584.shtml
CleanEx	HS_SLC5A11	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC5A11
DOI	10.1016/S0378-1119(02)00416-X	http://dx.doi.org/10.1016/S0378-1119(02)00416-X
DOI	10.1016/j.ymgme.2004.03.007	http://dx.doi.org/10.1016/j.ymgme.2004.03.007
DOI	10.1038/nature03187	http://dx.doi.org/10.1038/nature03187
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1399-0039.2007.00975.x	http://dx.doi.org/10.1111/j.1399-0039.2007.00975.x
EMBL	AC008731	http://www.ebi.ac.uk/ena/data/view/AC008731
EMBL	AF292385	http://www.ebi.ac.uk/ena/data/view/AF292385
EMBL	AJ305237	http://www.ebi.ac.uk/ena/data/view/AJ305237
EMBL	AK125267	http://www.ebi.ac.uk/ena/data/view/AK125267
EMBL	AK295427	http://www.ebi.ac.uk/ena/data/view/AK295427
EMBL	AY044906	http://www.ebi.ac.uk/ena/data/view/AY044906
EMBL	BC049385	http://www.ebi.ac.uk/ena/data/view/BC049385
EMBL	BC057780	http://www.ebi.ac.uk/ena/data/view/BC057780
EMBL	CH471145	http://www.ebi.ac.uk/ena/data/view/CH471145
Ensembl	ENST00000347898	http://www.ensembl.org/id/ENST00000347898
Ensembl	ENST00000424767	http://www.ensembl.org/id/ENST00000424767
Ensembl	ENST00000449109	http://www.ensembl.org/id/ENST00000449109
Ensembl	ENST00000545376	http://www.ensembl.org/id/ENST00000545376
Ensembl	ENST00000565769	http://www.ensembl.org/id/ENST00000565769
Ensembl	ENST00000567758	http://www.ensembl.org/id/ENST00000567758
Ensembl	ENST00000568579	http://www.ensembl.org/id/ENST00000568579
Ensembl	ENST00000569071	http://www.ensembl.org/id/ENST00000569071
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0015166	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015166
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0006915	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006915
GO_process	GO:0008643	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008643
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219
GeneCards	SLC5A11	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC5A11
GeneID	115584	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=115584
GeneTree	ENSGT00760000118955	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118955
H-InvDB	HIX0026944	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0026944
HGNC	HGNC:23091	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:23091
HOGENOM	HOG000025422	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000025422&db=HOGENOM6
HOVERGEN	HBG052859	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052859&db=HOVERGEN
HPA	HPA035331	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035331
InParanoid	Q8WWX8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8WWX8
IntAct	Q8WWX8	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8WWX8*
InterPro	IPR001734	http://www.ebi.ac.uk/interpro/entry/IPR001734
Jabion	115584	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=115584
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:115584	http://www.genome.jp/dbget-bin/www_bget?hsa:115584
KEGG_Orthology	KO:K14391	http://www.genome.jp/dbget-bin/www_bget?KO:K14391
MIM	610238	http://www.ncbi.nlm.nih.gov/omim/610238
OMA	KTHSCDM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KTHSCDM
OrthoDB	EOG091G077U	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G077U
PANTHER	PTHR11819	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11819
PROSITE	PS50283	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50283
PSORT	swissprot:SC5AB_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SC5AB_HUMAN
PSORT-B	swissprot:SC5AB_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SC5AB_HUMAN
PSORT2	swissprot:SC5AB_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SC5AB_HUMAN
Pfam	PF00474	http://pfam.xfam.org/family/PF00474
PharmGKB	PA134923660	http://www.pharmgkb.org/do/serve?objId=PA134923660&objCls=Gene
Phobius	swissprot:SC5AB_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SC5AB_HUMAN
PhylomeDB	Q8WWX8	http://phylomedb.org/?seqid=Q8WWX8
ProteinModelPortal	Q8WWX8	http://www.proteinmodelportal.org/query/uniprot/Q8WWX8
PubMed	12039040	http://www.ncbi.nlm.nih.gov/pubmed/12039040
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15172003	http://www.ncbi.nlm.nih.gov/pubmed/15172003
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15616553	http://www.ncbi.nlm.nih.gov/pubmed/15616553
PubMed	18069935	http://www.ncbi.nlm.nih.gov/pubmed/18069935
Reactome	R-HSA-429593	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-429593
RefSeq	NP_001245340	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001245340
RefSeq	NP_001245341	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001245341
RefSeq	NP_001245342	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001245342
RefSeq	NP_001245343	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001245343
RefSeq	NP_443176	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_443176
RefSeq	XP_005255137	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005255137
RefSeq	XP_016878389	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016878389
RefSeq	XP_016878390	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016878390
RefSeq	XP_016878391	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016878391
RefSeq	XP_016878392	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016878392
RefSeq	XP_016878394	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016878394
RefSeq	XP_016878395	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016878395
STRING	9606.ENSP00000289932	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000289932&targetmode=cogs
TCDB	2.A.21.3	http://www.tcdb.org/search/result.php?tc=2.A.21.3
TIGRFAMs	TIGR00813	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00813
UCSC	uc002dms	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002dms&org=rat
UniGene	Hs.164118	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.164118
UniProtKB	SC5AB_HUMAN	http://www.uniprot.org/uniprot/SC5AB_HUMAN
UniProtKB-AC	Q8WWX8	http://www.uniprot.org/uniprot/Q8WWX8
charge	swissprot:SC5AB_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SC5AB_HUMAN
eggNOG	COG4146	http://eggnogapi.embl.de/nog_data/html/tree/COG4146
eggNOG	ENOG410IP49	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IP49
epestfind	swissprot:SC5AB_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SC5AB_HUMAN
garnier	swissprot:SC5AB_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SC5AB_HUMAN
helixturnhelix	swissprot:SC5AB_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SC5AB_HUMAN
hmoment	swissprot:SC5AB_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SC5AB_HUMAN
iep	swissprot:SC5AB_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SC5AB_HUMAN
inforesidue	swissprot:SC5AB_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SC5AB_HUMAN
neXtProt	NX_Q8WWX8	http://www.nextprot.org/db/entry/NX_Q8WWX8
octanol	swissprot:SC5AB_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SC5AB_HUMAN
pepcoil	swissprot:SC5AB_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SC5AB_HUMAN
pepdigest	swissprot:SC5AB_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SC5AB_HUMAN
pepinfo	swissprot:SC5AB_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SC5AB_HUMAN
pepnet	swissprot:SC5AB_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SC5AB_HUMAN
pepstats	swissprot:SC5AB_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SC5AB_HUMAN
pepwheel	swissprot:SC5AB_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SC5AB_HUMAN
pepwindow	swissprot:SC5AB_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SC5AB_HUMAN
sigcleave	swissprot:SC5AB_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SC5AB_HUMAN
## Database	ID	URL or Descriptions
# AltName	GDC_HUMAN	Graves disease autoantigen
# AltName	GDC_HUMAN	Mitochondrial solute carrier protein homolog
# AltName	GDC_HUMAN	Solute carrier family 25 member 16
# BioGrid	113727	20
# Ensembl	ENST00000609923	ENSP00000476815; ENSG00000122912
# ExpressionAtlas	P16260	baseline and differential
# FUNCTION	GDC_HUMAN	Required for the accumulation of coenzyme A in the mitochondrial matrix. {ECO 0000269|PubMed 11158296}. 
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015291	secondary active transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015297	antiporter activity; NAS:UniProtKB.
# GO_process	GO:0006810	transport; NAS:UniProtKB.
# GO_process	GO:0009108	coenzyme biosynthetic process; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0051186	cofactor metabolic process
# Gene3D	1.50.40.10	-; 1.
# Genevisible	P16260	HS
# HGNC	HGNC:10986	SLC25A16
# InterPro	IPR002067	Mit_carrier
# InterPro	IPR002167	Graves_DC
# InterPro	IPR018108	Mitochondrial_sb/sol_carrier
# InterPro	IPR023395	Mt_carrier_dom
# KEGG_Brite	ko02001	Solute carrier family
# MIM	139080	gene
# Organism	GDC_HUMAN	Homo sapiens (Human)
# PIR	A40141	A40141
# PRINTS	PR00926	MITOCARRIER
# PRINTS	PR00928	GRAVESDC
# PROSITE	PS50920	SOLCAR; 3
# Pfam	PF00153	Mito_carr; 3
# Proteomes	UP000005640	Chromosome 10
# Reactome	R-HSA-196783	Coenzyme A biosynthesis
# RecName	GDC_HUMAN	Graves disease carrier protein
# RefSeq	NP_689920	NM_152707.3
# RefSeq	XP_011538513	XM_011540211.2
# SEQUENCE CAUTION	Sequence=AAA36329.1; Type=Frameshift; Positions=320; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the mitochondrial carrier (TC 2.A.29) family. {ECO	0000305}. 
# SIMILARITY	Contains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule	PRU00282}. 
# SUBCELLULAR LOCATION	GDC_HUMAN	Mitochondrion inner membrane {ECO 0000269|PubMed 11158296}; Multi-pass membrane protein {ECO 0000269|PubMed 11158296}. 
# SUPFAM	SSF103506	SSF103506
# TCDB	2.A.29.12	the mitochondrial carrier (mc) family
# UCSC	uc001joi	human
# eggNOG	ENOG410ZRF1	LUCA
# eggNOG	KOG0752	Eukaryota
BLAST	swissprot:GDC_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GDC_HUMAN
BioCyc	ZFISH:ENSG00000122912-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000122912-MONOMER
COXPRESdb	8034	http://coxpresdb.jp/data/gene/8034.shtml
CleanEx	HS_GDA	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GDA
CleanEx	HS_SLC25A16	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC25A16
DOI	10.1038/nature02462	http://dx.doi.org/10.1038/nature02462
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1128/MCB.21.4.1089-1097.2001	http://dx.doi.org/10.1128/MCB.21.4.1089-1097.2001
DOI	10.1210/mend-3-9-1498	http://dx.doi.org/10.1210/mend-3-9-1498
EMBL	AK290255	http://www.ebi.ac.uk/ena/data/view/AK290255
EMBL	AL713888	http://www.ebi.ac.uk/ena/data/view/AL713888
EMBL	BC030266	http://www.ebi.ac.uk/ena/data/view/BC030266
EMBL	CH471083	http://www.ebi.ac.uk/ena/data/view/CH471083
EMBL	M31659	http://www.ebi.ac.uk/ena/data/view/M31659
Ensembl	ENST00000609923	http://www.ensembl.org/id/ENST00000609923
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015291	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015291
GO_function	GO:0015297	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0009108	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009108
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0051186	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186
Gene3D	1.50.40.10	http://www.cathdb.info/version/latest/superfamily/1.50.40.10
GeneCards	SLC25A16	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC25A16
GeneID	8034	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8034
GeneTree	ENSGT00760000119245	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119245
HGNC	HGNC:10986	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10986
HOGENOM	HOG000165726	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000165726&db=HOGENOM6
HOVERGEN	HBG104402	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG104402&db=HOVERGEN
HPA	HPA044580	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA044580
InParanoid	P16260	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16260
InterPro	IPR002067	http://www.ebi.ac.uk/interpro/entry/IPR002067
InterPro	IPR002167	http://www.ebi.ac.uk/interpro/entry/IPR002167
InterPro	IPR018108	http://www.ebi.ac.uk/interpro/entry/IPR018108
InterPro	IPR023395	http://www.ebi.ac.uk/interpro/entry/IPR023395
Jabion	8034	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=8034
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:8034	http://www.genome.jp/dbget-bin/www_bget?hsa:8034
KEGG_Orthology	KO:K15084	http://www.genome.jp/dbget-bin/www_bget?KO:K15084
MIM	139080	http://www.ncbi.nlm.nih.gov/omim/139080
OMA	HHYKHLE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HHYKHLE
OrthoDB	EOG091G0C8S	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0C8S
PRINTS	PR00926	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00926
PRINTS	PR00928	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00928
PROSITE	PS50920	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50920
PSORT	swissprot:GDC_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GDC_HUMAN
PSORT-B	swissprot:GDC_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GDC_HUMAN
PSORT2	swissprot:GDC_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GDC_HUMAN
Pfam	PF00153	http://pfam.xfam.org/family/PF00153
PharmGKB	PA35862	http://www.pharmgkb.org/do/serve?objId=PA35862&objCls=Gene
Phobius	swissprot:GDC_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GDC_HUMAN
PhylomeDB	P16260	http://phylomedb.org/?seqid=P16260
ProteinModelPortal	P16260	http://www.proteinmodelportal.org/query/uniprot/P16260
PubMed	11158296	http://www.ncbi.nlm.nih.gov/pubmed/11158296
PubMed	1457817	http://www.ncbi.nlm.nih.gov/pubmed/1457817
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15164054	http://www.ncbi.nlm.nih.gov/pubmed/15164054
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	2575220	http://www.ncbi.nlm.nih.gov/pubmed/2575220
Reactome	R-HSA-196783	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-196783
RefSeq	NP_689920	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_689920
RefSeq	XP_011538513	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011538513
STRING	9606.ENSP00000265870	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000265870&targetmode=cogs
SUPFAM	SSF103506	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103506
TCDB	2.A.29.12	http://www.tcdb.org/search/result.php?tc=2.A.29.12
UCSC	uc001joi	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001joi&org=rat
UniGene	Hs.180408	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.180408
UniProtKB	GDC_HUMAN	http://www.uniprot.org/uniprot/GDC_HUMAN
UniProtKB-AC	P16260	http://www.uniprot.org/uniprot/P16260
charge	swissprot:GDC_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GDC_HUMAN
eggNOG	ENOG410ZRF1	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZRF1
eggNOG	KOG0752	http://eggnogapi.embl.de/nog_data/html/tree/KOG0752
epestfind	swissprot:GDC_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GDC_HUMAN
garnier	swissprot:GDC_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GDC_HUMAN
helixturnhelix	swissprot:GDC_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GDC_HUMAN
hmoment	swissprot:GDC_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GDC_HUMAN
iep	swissprot:GDC_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GDC_HUMAN
inforesidue	swissprot:GDC_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GDC_HUMAN
neXtProt	NX_P16260	http://www.nextprot.org/db/entry/NX_P16260
octanol	swissprot:GDC_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GDC_HUMAN
pepcoil	swissprot:GDC_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GDC_HUMAN
pepdigest	swissprot:GDC_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GDC_HUMAN
pepinfo	swissprot:GDC_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GDC_HUMAN
pepnet	swissprot:GDC_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GDC_HUMAN
pepstats	swissprot:GDC_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GDC_HUMAN
pepwheel	swissprot:GDC_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GDC_HUMAN
pepwindow	swissprot:GDC_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GDC_HUMAN
sigcleave	swissprot:GDC_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GDC_HUMAN
## Database	ID	URL or Descriptions
# AltName	VAS1_HUMAN	Protein XAP-3
# AltName	VAS1_HUMAN	V-ATPase Ac45 subunit
# AltName	VAS1_HUMAN	V-ATPase S1 accessory protein
# AltName	VAS1_HUMAN	Vacuolar proton pump subunit S1
# BioGrid	107019	33
# ChiTaRS	ATP6AP1	human
# Ensembl	ENST00000369762	ENSP00000358777; ENSG00000071553
# ExpressionAtlas	Q15904	baseline and differential
# FUNCTION	VAS1_HUMAN	Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. {ECO 0000250}. 
# GO_component	GO:0010008	endosome membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0016469	proton-transporting two-sector ATPase complex; TAS:ProtInc.
# GO_component	GO:0033180	proton-transporting V-type ATPase, V1 domain; IEA:InterPro.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005215	transporter activity; TAS:ProtInc.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0017137	Rab GTPase binding; ISS:UniProtKB.
# GO_function	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism; IEA:InterPro.
# GO_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
# GO_process	GO:0008286	insulin receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0015991	ATP hydrolysis coupled proton transport; IEA:InterPro.
# GO_process	GO:0015992	proton transport; TAS:ProtInc.
# GO_process	GO:0033572	transferrin transport; TAS:Reactome.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0045669	positive regulation of osteoblast differentiation; ISS:UniProtKB.
# GO_process	GO:0045780	positive regulation of bone resorption; ISS:UniProtKB.
# GO_process	GO:0045851	pH reduction; ISS:UniProtKB.
# GO_process	GO:0045921	positive regulation of exocytosis; ISS:UniProtKB.
# GO_process	GO:0051656	establishment of organelle localization; ISS:UniProtKB.
# GO_process	GO:0070374	positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
# GO_process	GO:2001206	positive regulation of osteoclast development; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q15904	HS
# HGNC	HGNC:868	ATP6AP1
# IntAct	Q15904	23
# InterPro	IPR008388	ATPase_V1-cplx_s1su
# InterPro	IPR024722	ATPase_V1_suS1_fam
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04142	Lysosome
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko05110	Vibrio cholerae infection
# KEGG_Pathway	ko05120	Epithelial cell signaling in Helicobacter pylori infection
# KEGG_Pathway	ko05152	Tuberculosis
# KEGG_Pathway	ko05161	Hepatitis B
# KEGG_Pathway	ko05323	Rheumatoid arthritis
# MIM	300197	gene
# Organism	VAS1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12471	PTHR12471
# Pfam	PF05827	ATP-synt_S1
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-77387	Insulin receptor recycling
# Reactome	R-HSA-917977	Transferrin endocytosis and recycling
# Reactome	R-HSA-983712	Ion channel transport
# RecName	VAS1_HUMAN	V-type proton ATPase subunit S1
# RefSeq	NP_001174	NM_001183.5
# RefSeq	XP_011529481	XM_011531179.1
# SEQUENCE CAUTION	Sequence=BAA03938.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB66785.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the vacuolar ATPase subunit S1 family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	VAS1_HUMAN	Vacuole membrane {ECO 0000250}; Single-pass membrane protein {ECO 0000250}. 
# SUBUNIT	VAS1_HUMAN	Composed of at least 10 subunits. 
# TISSUE SPECIFICITY	VAS1_HUMAN	Ubiquitous. 
# UCSC	uc004flf	human
# eggNOG	ENOG410XTHY	LUCA
# eggNOG	KOG3868	Eukaryota
BLAST	swissprot:VAS1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VAS1_HUMAN
BioCyc	MetaCyc:HS01034-MONOMER	http://biocyc.org/getid?id=MetaCyc:HS01034-MONOMER
BioCyc	ZFISH:HS01034-MONOMER	http://biocyc.org/getid?id=ZFISH:HS01034-MONOMER
COXPRESdb	537	http://coxpresdb.jp/data/gene/537.shtml
CleanEx	HS_ATP6AP1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP6AP1
DOI	10.1006/geno.1994.1194	http://dx.doi.org/10.1006/geno.1994.1194
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/dnares/12.2.117	http://dx.doi.org/10.1093/dnares/12.2.117
DOI	10.1093/hmg/5.5.659	http://dx.doi.org/10.1093/hmg/5.5.659
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1101/gr.GR1547R	http://dx.doi.org/10.1101/gr.GR1547R
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AK026519	http://www.ebi.ac.uk/ena/data/view/AK026519
EMBL	AK075284	http://www.ebi.ac.uk/ena/data/view/AK075284
EMBL	AK289452	http://www.ebi.ac.uk/ena/data/view/AK289452
EMBL	AL136851	http://www.ebi.ac.uk/ena/data/view/AL136851
EMBL	BC000724	http://www.ebi.ac.uk/ena/data/view/BC000724
EMBL	BX936347	http://www.ebi.ac.uk/ena/data/view/BX936347
EMBL	BX936347	http://www.ebi.ac.uk/ena/data/view/BX936347
EMBL	BX936385	http://www.ebi.ac.uk/ena/data/view/BX936385
EMBL	BX936385	http://www.ebi.ac.uk/ena/data/view/BX936385
EMBL	CH471172	http://www.ebi.ac.uk/ena/data/view/CH471172
EMBL	D16469	http://www.ebi.ac.uk/ena/data/view/D16469
EMBL	L44140	http://www.ebi.ac.uk/ena/data/view/L44140
Ensembl	ENST00000369762	http://www.ensembl.org/id/ENST00000369762
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0010008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010008
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016469	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016469
GO_component	GO:0033180	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033180
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0017137	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017137
GO_function	GO:0046933	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046933
GO_function	GO:0046961	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046961
GO_process	GO:0008286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008286
GO_process	GO:0015991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015991
GO_process	GO:0015992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992
GO_process	GO:0033572	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033572
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0045669	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045669
GO_process	GO:0045780	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045780
GO_process	GO:0045851	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045851
GO_process	GO:0045921	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045921
GO_process	GO:0051656	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051656
GO_process	GO:0070374	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070374
GO_process	GO:2001206	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001206
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ATP6AP1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP6AP1
GeneID	537	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=537
GeneTree	ENSGT00530000063584	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063584
HGNC	HGNC:868	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:868
HOGENOM	HOG000000706	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000000706&db=HOGENOM6
HOVERGEN	HBG001090	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG001090&db=HOVERGEN
HPA	CAB015218	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB015218
InParanoid	Q15904	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q15904
IntAct	Q15904	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q15904*
InterPro	IPR008388	http://www.ebi.ac.uk/interpro/entry/IPR008388
InterPro	IPR024722	http://www.ebi.ac.uk/interpro/entry/IPR024722
Jabion	537	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=537
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:537	http://www.genome.jp/dbget-bin/www_bget?hsa:537
KEGG_Orthology	KO:K03662	http://www.genome.jp/dbget-bin/www_bget?KO:K03662
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04142	http://www.genome.jp/kegg-bin/show_pathway?ko04142
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko05110	http://www.genome.jp/kegg-bin/show_pathway?ko05110
KEGG_Pathway	ko05120	http://www.genome.jp/kegg-bin/show_pathway?ko05120
KEGG_Pathway	ko05152	http://www.genome.jp/kegg-bin/show_pathway?ko05152
KEGG_Pathway	ko05161	http://www.genome.jp/kegg-bin/show_pathway?ko05161
KEGG_Pathway	ko05323	http://www.genome.jp/kegg-bin/show_pathway?ko05323
MIM	300197	http://www.ncbi.nlm.nih.gov/omim/300197
MINT	MINT-4722342	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4722342
OMA	GHITSDM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GHITSDM
OrthoDB	EOG091G0772	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0772
PANTHER	PTHR12471	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12471
PSORT	swissprot:VAS1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VAS1_HUMAN
PSORT-B	swissprot:VAS1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VAS1_HUMAN
PSORT2	swissprot:VAS1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VAS1_HUMAN
Pfam	PF05827	http://pfam.xfam.org/family/PF05827
PharmGKB	PA25145	http://www.pharmgkb.org/do/serve?objId=PA25145&objCls=Gene
Phobius	swissprot:VAS1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VAS1_HUMAN
PhylomeDB	Q15904	http://phylomedb.org/?seqid=Q15904
ProteinModelPortal	Q15904	http://www.proteinmodelportal.org/query/uniprot/Q15904
PubMed	11230166	http://www.ncbi.nlm.nih.gov/pubmed/11230166
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	16303743	http://www.ncbi.nlm.nih.gov/pubmed/16303743
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	8034313	http://www.ncbi.nlm.nih.gov/pubmed/8034313
PubMed	8733135	http://www.ncbi.nlm.nih.gov/pubmed/8733135
Reactome	R-HSA-77387	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-77387
Reactome	R-HSA-917977	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917977
Reactome	R-HSA-983712	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983712
RefSeq	NP_001174	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001174
RefSeq	XP_011529481	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011529481
STRING	9606.ENSP00000358777	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000358777&targetmode=cogs
UCSC	uc004flf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004flf&org=rat
UniGene	Hs.633817	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.633817
UniGene	Hs.6551	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.6551
UniProtKB	VAS1_HUMAN	http://www.uniprot.org/uniprot/VAS1_HUMAN
UniProtKB-AC	Q15904	http://www.uniprot.org/uniprot/Q15904
charge	swissprot:VAS1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VAS1_HUMAN
eggNOG	ENOG410XTHY	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XTHY
eggNOG	KOG3868	http://eggnogapi.embl.de/nog_data/html/tree/KOG3868
epestfind	swissprot:VAS1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VAS1_HUMAN
garnier	swissprot:VAS1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VAS1_HUMAN
helixturnhelix	swissprot:VAS1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VAS1_HUMAN
hmoment	swissprot:VAS1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VAS1_HUMAN
iep	swissprot:VAS1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VAS1_HUMAN
inforesidue	swissprot:VAS1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VAS1_HUMAN
neXtProt	NX_Q15904	http://www.nextprot.org/db/entry/NX_Q15904
octanol	swissprot:VAS1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VAS1_HUMAN
pepcoil	swissprot:VAS1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VAS1_HUMAN
pepdigest	swissprot:VAS1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VAS1_HUMAN
pepinfo	swissprot:VAS1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VAS1_HUMAN
pepnet	swissprot:VAS1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VAS1_HUMAN
pepstats	swissprot:VAS1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VAS1_HUMAN
pepwheel	swissprot:VAS1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VAS1_HUMAN
pepwindow	swissprot:VAS1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VAS1_HUMAN
sigcleave	swissprot:VAS1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VAS1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	MRP1_HUMAN	Event=Alternative splicing; Named isoforms=9; Comment=Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms.; Name=1; Synonyms=Allexons; IsoId=P33527-1; Sequence=Displayed; Name=2; Synonyms=Delexon-17; IsoId=P33527-2; Sequence=VSP_000037; Name=3; Synonyms=Delexon-18; IsoId=P33527-3; Sequence=VSP_000038; Name=4; Synonyms=Delexon-30; IsoId=P33527-4; Sequence=VSP_000039; Name=5; Synonyms=Delexon-17-18; IsoId=P33527-5; Sequence=VSP_000037, VSP_000038; Name=6; Synonyms=Delexon-17-30; IsoId=P33527-6; Sequence=VSP_000037, VSP_000039; Name=7; Synonyms=Delexon-18-30; IsoId=P33527-7; Sequence=VSP_000038, VSP_000039; Name=8; Synonyms=Delexon-17-18-30; IsoId=P33527-8; Sequence=VSP_000037, VSP_000038, VSP_000039; Name=9; IsoId=P33527-9; Sequence=VSP_017014; Note=No experimental confirmation available.; 
# AltName	MRP1_HUMAN	ATP-binding cassette sub-family C member 1
# AltName	MRP1_HUMAN	Leukotriene C(4) transporter
# BioGrid	110503	51
# CCDS	CCDS42122	-. [P33527-1]
# ChiTaRS	ABCC1	human
# DrugBank	DB00091	Cyclosporine
# DrugBank	DB00143	Glutathione
# DrugBank	DB00199	Erythromycin
# DrugBank	DB00224	Indinavir
# DrugBank	DB00286	Conjugated Estrogens
# DrugBank	DB00328	Indomethacin
# DrugBank	DB00345	Aminohippurate
# DrugBank	DB00396	Progesterone
# DrugBank	DB00399	Zoledronate
# DrugBank	DB00445	Epirubicin
# DrugBank	DB00503	Ritonavir
# DrugBank	DB00541	Vincristine
# DrugBank	DB00563	Methotrexate
# DrugBank	DB00570	Vinblastine
# DrugBank	DB00586	Diclofenac
# DrugBank	DB00602	Ivermectin
# DrugBank	DB00661	Verapamil
# DrugBank	DB00693	Fluorescein
# DrugBank	DB00694	Daunorubicin
# DrugBank	DB00701	Amprenavir
# DrugBank	DB00709	Lamivudine
# DrugBank	DB00762	Irinotecan
# DrugBank	DB00773	Etoposide
# DrugBank	DB00834	Mifepristone
# DrugBank	DB00970	Dactinomycin
# DrugBank	DB00997	Doxorubicin
# DrugBank	DB01016	Glyburide
# DrugBank	DB01032	Probenecid
# DrugBank	DB01045	Rifampicin
# DrugBank	DB01050	Ibuprofen
# DrugBank	DB01072	Atazanavir
# DrugBank	DB01076	Atorvastatin
# DrugBank	DB01098	Rosuvastatin
# DrugBank	DB01138	Sulfinpyrazone
# DrugBank	DB01165	Ofloxacin
# DrugBank	DB01174	Phenobarbital
# DrugBank	DB01177	Idarubicin
# DrugBank	DB01204	Mitoxantrone
# DrugBank	DB01229	Paclitaxel
# DrugBank	DB01232	Saquinavir
# DrugBank	DB01248	Docetaxel
# DrugBank	DB01394	Colchicine
# DrugBank	DB02659	Cholic Acid
# DrugBank	DB05294	Vandetanib
# DrugBank	DB05812	Abiraterone
# DrugBank	DB06335	Saxagliptin
# DrugBank	DB08881	Vemurafenib
# Ensembl	ENST00000399410	ENSP00000382342; ENSG00000103222. [P33527-1]
# Ensembl	ENST00000621144	ENSP00000483316; ENSG00000278183. [P33527-1]
# ExpressionAtlas	P33527	baseline and differential
# FUNCTION	MRP1_HUMAN	Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o- glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency. {ECO 0000269|PubMed 10064732, ECO 0000269|PubMed 11114332, ECO 0000269|PubMed 16230346}. 
# GO_component	GO:0005886	plasma membrane; IDA:HPA.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016323	basolateral plasma membrane; IDA:CACAO.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005215	transporter activity; TAS:ProtInc.
# GO_function	GO:0005524	ATP binding; TAS:ProtInc.
# GO_function	GO:0015420	cobalamin-transporting ATPase activity; TAS:Reactome.
# GO_function	GO:0016887	ATPase activity; IDA:UniProtKB.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; TAS:Reactome.
# GO_function	GO:0043225	ATPase-coupled anion transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0006691	leukotriene metabolic process; TAS:Reactome.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0009235	cobalamin metabolic process; TAS:Reactome.
# GO_process	GO:0042493	response to drug; TAS:ProtInc.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 2.
# Genevisible	P33527	HS
# HGNC	HGNC:51	ABCC1
# IntAct	P33527	14
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR005292	Multidrug-R_assoc
# InterPro	IPR011527	ABC1_TM_dom
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR027417	P-loop_NTPase
# InterPro	IPR030241	ABCC1
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko02010	ABC transporters
# KEGG_Pathway	ko04977	Vitamin digestion and absorption
# MIM	158343	gene
# Organism	MRP1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR24223:SF241	PTHR24223:SF241; 2
# PDB	2CBZ	X-ray; 1.50 A; A=642-871
# PDB	4C3Z	X-ray; 2.10 A; A=628-881
# PIR	A44231	DVHUAR
# PROSITE	PS00211	ABC_TRANSPORTER_1; 2
# PROSITE	PS50893	ABC_TRANSPORTER_2; 2
# PROSITE	PS50929	ABC_TM1F; 2
# Pfam	PF00005	ABC_tran; 2
# Pfam	PF00664	ABC_membrane; 2
# Proteomes	UP000005640	Chromosome 16
# Reactome	R-HSA-196741	Cobalamin (Cbl, vitamin B12) transport and metabolism
# Reactome	R-HSA-2142691	Synthesis of Leukotrienes (LT) and Eoxins (EX)
# Reactome	R-HSA-382556	ABC-family proteins mediated transport
# RecName	MRP1_HUMAN	Multidrug resistance-associated protein 1
# RefSeq	NP_004987	NM_004996.3. [P33527-1]
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 2 ABC transmembrane type-1 domains. {ECO:0000255|PROSITE-ProRule	PRU00441}. 
# SIMILARITY	Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA; 2
# SUBCELLULAR LOCATION	MRP1_HUMAN	Cell membrane {ECO 0000269|PubMed 16230346}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00441, ECO 0000269|PubMed 16230346}. 
# SUPFAM	SSF52540	SSF52540; 2
# SUPFAM	SSF90123	SSF90123; 2
# TCDB	3.A.1.208	the atp-binding cassette (abc) superfamily
# TIGRFAMs	TIGR00957	MRP_assoc_pro
# TISSUE SPECIFICITY	MRP1_HUMAN	Lung, testis and peripheral blood mononuclear cells. 
# UCSC	uc010bvi	human. [P33527-1]
# WEB RESOURCE	MRP1_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=P33527";
# WEB RESOURCE	MRP1_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/MRPID106.html"; 
# WEB RESOURCE	MRP1_HUMAN	Name=NIEHS-SNPs; URL="http //egp.gs.washington.edu/data/abcc1/"; 
# eggNOG	COG1132	LUCA
# eggNOG	KOG0054	Eukaryota
BLAST	swissprot:MRP1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MRP1_HUMAN
BioCyc	ZFISH:ENSG00000103222-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000103222-MONOMER
COXPRESdb	4363	http://coxpresdb.jp/data/gene/4363.shtml
CleanEx	HS_ABCC1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCC1
DOI	10.1002/1098-1004(2001)17:1<74::AID-HUMU14>3.0.CO	http://dx.doi.org/10.1002/1098-1004(2001)17:1<74::AID-HUMU14>3.0.CO
DOI	10.1006/abbi.2001.2441	http://dx.doi.org/10.1006/abbi.2001.2441
DOI	10.1006/geno.1997.4950	http://dx.doi.org/10.1006/geno.1997.4950
DOI	10.1006/geno.1999.5927	http://dx.doi.org/10.1006/geno.1999.5927
DOI	10.1007/s100380170017	http://dx.doi.org/10.1007/s100380170017
DOI	10.1016/S0092-8674(00)00179-3	http://dx.doi.org/10.1016/S0092-8674(00)00179-3
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.jmb.2006.04.005	http://dx.doi.org/10.1016/j.jmb.2006.04.005
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/bi0495230	http://dx.doi.org/10.1021/bi0495230
DOI	10.1021/bi972332v	http://dx.doi.org/10.1021/bi972332v
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/76102	http://dx.doi.org/10.1038/76102
DOI	10.1038/nature03187	http://dx.doi.org/10.1038/nature03187
DOI	10.1038/nature07485	http://dx.doi.org/10.1038/nature07485
DOI	10.1073/pnas.100041297	http://dx.doi.org/10.1073/pnas.100041297
DOI	10.1074/jbc.272.38.23623	http://dx.doi.org/10.1074/jbc.272.38.23623
DOI	10.1074/jbc.272.42.26479	http://dx.doi.org/10.1074/jbc.272.42.26479
DOI	10.1074/jbc.M010008200	http://dx.doi.org/10.1074/jbc.M010008200
DOI	10.1074/jbc.M011246200	http://dx.doi.org/10.1074/jbc.M011246200
DOI	10.1074/jbc.M403832200	http://dx.doi.org/10.1074/jbc.M403832200
DOI	10.1074/jbc.M510143200	http://dx.doi.org/10.1074/jbc.M510143200
DOI	10.1097/00008571-200103000-00008	http://dx.doi.org/10.1097/00008571-200103000-00008
DOI	10.1126/science.1360704	http://dx.doi.org/10.1126/science.1360704
DOI	10.1126/science.8098549	http://dx.doi.org/10.1126/science.8098549
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DrugBank	DB00091	http://www.drugbank.ca/drugs/DB00091
DrugBank	DB00143	http://www.drugbank.ca/drugs/DB00143
DrugBank	DB00199	http://www.drugbank.ca/drugs/DB00199
DrugBank	DB00224	http://www.drugbank.ca/drugs/DB00224
DrugBank	DB00286	http://www.drugbank.ca/drugs/DB00286
DrugBank	DB00328	http://www.drugbank.ca/drugs/DB00328
DrugBank	DB00345	http://www.drugbank.ca/drugs/DB00345
DrugBank	DB00396	http://www.drugbank.ca/drugs/DB00396
DrugBank	DB00399	http://www.drugbank.ca/drugs/DB00399
DrugBank	DB00445	http://www.drugbank.ca/drugs/DB00445
DrugBank	DB00503	http://www.drugbank.ca/drugs/DB00503
DrugBank	DB00541	http://www.drugbank.ca/drugs/DB00541
DrugBank	DB00563	http://www.drugbank.ca/drugs/DB00563
DrugBank	DB00570	http://www.drugbank.ca/drugs/DB00570
DrugBank	DB00586	http://www.drugbank.ca/drugs/DB00586
DrugBank	DB00602	http://www.drugbank.ca/drugs/DB00602
DrugBank	DB00661	http://www.drugbank.ca/drugs/DB00661
DrugBank	DB00693	http://www.drugbank.ca/drugs/DB00693
DrugBank	DB00694	http://www.drugbank.ca/drugs/DB00694
DrugBank	DB00701	http://www.drugbank.ca/drugs/DB00701
DrugBank	DB00709	http://www.drugbank.ca/drugs/DB00709
DrugBank	DB00762	http://www.drugbank.ca/drugs/DB00762
DrugBank	DB00773	http://www.drugbank.ca/drugs/DB00773
DrugBank	DB00834	http://www.drugbank.ca/drugs/DB00834
DrugBank	DB00970	http://www.drugbank.ca/drugs/DB00970
DrugBank	DB00997	http://www.drugbank.ca/drugs/DB00997
DrugBank	DB01016	http://www.drugbank.ca/drugs/DB01016
DrugBank	DB01032	http://www.drugbank.ca/drugs/DB01032
DrugBank	DB01045	http://www.drugbank.ca/drugs/DB01045
DrugBank	DB01050	http://www.drugbank.ca/drugs/DB01050
DrugBank	DB01072	http://www.drugbank.ca/drugs/DB01072
DrugBank	DB01076	http://www.drugbank.ca/drugs/DB01076
DrugBank	DB01098	http://www.drugbank.ca/drugs/DB01098
DrugBank	DB01138	http://www.drugbank.ca/drugs/DB01138
DrugBank	DB01165	http://www.drugbank.ca/drugs/DB01165
DrugBank	DB01174	http://www.drugbank.ca/drugs/DB01174
DrugBank	DB01177	http://www.drugbank.ca/drugs/DB01177
DrugBank	DB01204	http://www.drugbank.ca/drugs/DB01204
DrugBank	DB01229	http://www.drugbank.ca/drugs/DB01229
DrugBank	DB01232	http://www.drugbank.ca/drugs/DB01232
DrugBank	DB01248	http://www.drugbank.ca/drugs/DB01248
DrugBank	DB01394	http://www.drugbank.ca/drugs/DB01394
DrugBank	DB02659	http://www.drugbank.ca/drugs/DB02659
DrugBank	DB05294	http://www.drugbank.ca/drugs/DB05294
DrugBank	DB05812	http://www.drugbank.ca/drugs/DB05812
DrugBank	DB06335	http://www.drugbank.ca/drugs/DB06335
DrugBank	DB08881	http://www.drugbank.ca/drugs/DB08881
EMBL	AB209120	http://www.ebi.ac.uk/ena/data/view/AB209120
EMBL	AC003026	http://www.ebi.ac.uk/ena/data/view/AC003026
EMBL	AC025778	http://www.ebi.ac.uk/ena/data/view/AC025778
EMBL	AC130651	http://www.ebi.ac.uk/ena/data/view/AC130651
EMBL	AC136624	http://www.ebi.ac.uk/ena/data/view/AC136624
EMBL	AF022824	http://www.ebi.ac.uk/ena/data/view/AF022824
EMBL	AF022824	http://www.ebi.ac.uk/ena/data/view/AF022824
EMBL	AF022824	http://www.ebi.ac.uk/ena/data/view/AF022824
EMBL	AF022824	http://www.ebi.ac.uk/ena/data/view/AF022824
EMBL	AF022825	http://www.ebi.ac.uk/ena/data/view/AF022825
EMBL	AF022825	http://www.ebi.ac.uk/ena/data/view/AF022825
EMBL	AF022825	http://www.ebi.ac.uk/ena/data/view/AF022825
EMBL	AF022825	http://www.ebi.ac.uk/ena/data/view/AF022825
EMBL	AF022826	http://www.ebi.ac.uk/ena/data/view/AF022826
EMBL	AF022826	http://www.ebi.ac.uk/ena/data/view/AF022826
EMBL	AF022826	http://www.ebi.ac.uk/ena/data/view/AF022826
EMBL	AF022826	http://www.ebi.ac.uk/ena/data/view/AF022826
EMBL	AF022827	http://www.ebi.ac.uk/ena/data/view/AF022827
EMBL	AF022827	http://www.ebi.ac.uk/ena/data/view/AF022827
EMBL	AF022827	http://www.ebi.ac.uk/ena/data/view/AF022827
EMBL	AF022827	http://www.ebi.ac.uk/ena/data/view/AF022827
EMBL	AF022828	http://www.ebi.ac.uk/ena/data/view/AF022828
EMBL	AF022828	http://www.ebi.ac.uk/ena/data/view/AF022828
EMBL	AF022828	http://www.ebi.ac.uk/ena/data/view/AF022828
EMBL	AF022828	http://www.ebi.ac.uk/ena/data/view/AF022828
EMBL	AF022829	http://www.ebi.ac.uk/ena/data/view/AF022829
EMBL	AF022829	http://www.ebi.ac.uk/ena/data/view/AF022829
EMBL	AF022829	http://www.ebi.ac.uk/ena/data/view/AF022829
EMBL	AF022829	http://www.ebi.ac.uk/ena/data/view/AF022829
EMBL	AF022830	http://www.ebi.ac.uk/ena/data/view/AF022830
EMBL	AF022830	http://www.ebi.ac.uk/ena/data/view/AF022830
EMBL	AF022830	http://www.ebi.ac.uk/ena/data/view/AF022830
EMBL	AF022830	http://www.ebi.ac.uk/ena/data/view/AF022830
EMBL	AF022831	http://www.ebi.ac.uk/ena/data/view/AF022831
EMBL	AF022831	http://www.ebi.ac.uk/ena/data/view/AF022831
EMBL	AF022831	http://www.ebi.ac.uk/ena/data/view/AF022831
EMBL	AF022831	http://www.ebi.ac.uk/ena/data/view/AF022831
EMBL	AF022832	http://www.ebi.ac.uk/ena/data/view/AF022832
EMBL	AF022832	http://www.ebi.ac.uk/ena/data/view/AF022832
EMBL	AF022832	http://www.ebi.ac.uk/ena/data/view/AF022832
EMBL	AF022832	http://www.ebi.ac.uk/ena/data/view/AF022832
EMBL	AF022833	http://www.ebi.ac.uk/ena/data/view/AF022833
EMBL	AF022833	http://www.ebi.ac.uk/ena/data/view/AF022833
EMBL	AF022833	http://www.ebi.ac.uk/ena/data/view/AF022833
EMBL	AF022833	http://www.ebi.ac.uk/ena/data/view/AF022833
EMBL	AF022834	http://www.ebi.ac.uk/ena/data/view/AF022834
EMBL	AF022834	http://www.ebi.ac.uk/ena/data/view/AF022834
EMBL	AF022834	http://www.ebi.ac.uk/ena/data/view/AF022834
EMBL	AF022834	http://www.ebi.ac.uk/ena/data/view/AF022834
EMBL	AF022835	http://www.ebi.ac.uk/ena/data/view/AF022835
EMBL	AF022835	http://www.ebi.ac.uk/ena/data/view/AF022835
EMBL	AF022835	http://www.ebi.ac.uk/ena/data/view/AF022835
EMBL	AF022835	http://www.ebi.ac.uk/ena/data/view/AF022835
EMBL	AF022836	http://www.ebi.ac.uk/ena/data/view/AF022836
EMBL	AF022836	http://www.ebi.ac.uk/ena/data/view/AF022836
EMBL	AF022836	http://www.ebi.ac.uk/ena/data/view/AF022836
EMBL	AF022836	http://www.ebi.ac.uk/ena/data/view/AF022836
EMBL	AF022837	http://www.ebi.ac.uk/ena/data/view/AF022837
EMBL	AF022837	http://www.ebi.ac.uk/ena/data/view/AF022837
EMBL	AF022837	http://www.ebi.ac.uk/ena/data/view/AF022837
EMBL	AF022837	http://www.ebi.ac.uk/ena/data/view/AF022837
EMBL	AF022838	http://www.ebi.ac.uk/ena/data/view/AF022838
EMBL	AF022838	http://www.ebi.ac.uk/ena/data/view/AF022838
EMBL	AF022838	http://www.ebi.ac.uk/ena/data/view/AF022838
EMBL	AF022838	http://www.ebi.ac.uk/ena/data/view/AF022838
EMBL	AF022839	http://www.ebi.ac.uk/ena/data/view/AF022839
EMBL	AF022839	http://www.ebi.ac.uk/ena/data/view/AF022839
EMBL	AF022839	http://www.ebi.ac.uk/ena/data/view/AF022839
EMBL	AF022840	http://www.ebi.ac.uk/ena/data/view/AF022840
EMBL	AF022840	http://www.ebi.ac.uk/ena/data/view/AF022840
EMBL	AF022840	http://www.ebi.ac.uk/ena/data/view/AF022840
EMBL	AF022841	http://www.ebi.ac.uk/ena/data/view/AF022841
EMBL	AF022841	http://www.ebi.ac.uk/ena/data/view/AF022841
EMBL	AF022841	http://www.ebi.ac.uk/ena/data/view/AF022841
EMBL	AF022841	http://www.ebi.ac.uk/ena/data/view/AF022841
EMBL	AF022842	http://www.ebi.ac.uk/ena/data/view/AF022842
EMBL	AF022842	http://www.ebi.ac.uk/ena/data/view/AF022842
EMBL	AF022842	http://www.ebi.ac.uk/ena/data/view/AF022842
EMBL	AF022842	http://www.ebi.ac.uk/ena/data/view/AF022842
EMBL	AF022843	http://www.ebi.ac.uk/ena/data/view/AF022843
EMBL	AF022843	http://www.ebi.ac.uk/ena/data/view/AF022843
EMBL	AF022843	http://www.ebi.ac.uk/ena/data/view/AF022843
EMBL	AF022843	http://www.ebi.ac.uk/ena/data/view/AF022843
EMBL	AF022844	http://www.ebi.ac.uk/ena/data/view/AF022844
EMBL	AF022844	http://www.ebi.ac.uk/ena/data/view/AF022844
EMBL	AF022844	http://www.ebi.ac.uk/ena/data/view/AF022844
EMBL	AF022844	http://www.ebi.ac.uk/ena/data/view/AF022844
EMBL	AF022845	http://www.ebi.ac.uk/ena/data/view/AF022845
EMBL	AF022845	http://www.ebi.ac.uk/ena/data/view/AF022845
EMBL	AF022845	http://www.ebi.ac.uk/ena/data/view/AF022845
EMBL	AF022845	http://www.ebi.ac.uk/ena/data/view/AF022845
EMBL	AF022846	http://www.ebi.ac.uk/ena/data/view/AF022846
EMBL	AF022846	http://www.ebi.ac.uk/ena/data/view/AF022846
EMBL	AF022846	http://www.ebi.ac.uk/ena/data/view/AF022846
EMBL	AF022846	http://www.ebi.ac.uk/ena/data/view/AF022846
EMBL	AF022847	http://www.ebi.ac.uk/ena/data/view/AF022847
EMBL	AF022847	http://www.ebi.ac.uk/ena/data/view/AF022847
EMBL	AF022847	http://www.ebi.ac.uk/ena/data/view/AF022847
EMBL	AF022847	http://www.ebi.ac.uk/ena/data/view/AF022847
EMBL	AF022848	http://www.ebi.ac.uk/ena/data/view/AF022848
EMBL	AF022848	http://www.ebi.ac.uk/ena/data/view/AF022848
EMBL	AF022848	http://www.ebi.ac.uk/ena/data/view/AF022848
EMBL	AF022848	http://www.ebi.ac.uk/ena/data/view/AF022848
EMBL	AF022849	http://www.ebi.ac.uk/ena/data/view/AF022849
EMBL	AF022849	http://www.ebi.ac.uk/ena/data/view/AF022849
EMBL	AF022849	http://www.ebi.ac.uk/ena/data/view/AF022849
EMBL	AF022849	http://www.ebi.ac.uk/ena/data/view/AF022849
EMBL	AF022850	http://www.ebi.ac.uk/ena/data/view/AF022850
EMBL	AF022850	http://www.ebi.ac.uk/ena/data/view/AF022850
EMBL	AF022850	http://www.ebi.ac.uk/ena/data/view/AF022850
EMBL	AF022850	http://www.ebi.ac.uk/ena/data/view/AF022850
EMBL	AF022851	http://www.ebi.ac.uk/ena/data/view/AF022851
EMBL	AF022851	http://www.ebi.ac.uk/ena/data/view/AF022851
EMBL	AF022851	http://www.ebi.ac.uk/ena/data/view/AF022851
EMBL	AF022851	http://www.ebi.ac.uk/ena/data/view/AF022851
EMBL	AF022852	http://www.ebi.ac.uk/ena/data/view/AF022852
EMBL	AF022852	http://www.ebi.ac.uk/ena/data/view/AF022852
EMBL	AF022852	http://www.ebi.ac.uk/ena/data/view/AF022852
EMBL	AF022853	http://www.ebi.ac.uk/ena/data/view/AF022853
EMBL	AF022853	http://www.ebi.ac.uk/ena/data/view/AF022853
EMBL	AF022853	http://www.ebi.ac.uk/ena/data/view/AF022853
EMBL	AF022853	http://www.ebi.ac.uk/ena/data/view/AF022853
EMBL	EF419769	http://www.ebi.ac.uk/ena/data/view/EF419769
EMBL	L05628	http://www.ebi.ac.uk/ena/data/view/L05628
EMBL	U91318	http://www.ebi.ac.uk/ena/data/view/U91318
Ensembl	ENST00000399410	http://www.ensembl.org/id/ENST00000399410
Ensembl	ENST00000621144	http://www.ensembl.org/id/ENST00000621144
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0015420	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015420
GO_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GO_function	GO:0043225	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043225
GO_process	GO:0006691	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006691
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0009235	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009235
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCC1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCC1
GeneID	4363	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4363
GeneTree	ENSGT00860000133722	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00860000133722
H-InvDB	HIX0134370	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0134370
HGNC	HGNC:51	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:51
HOVERGEN	HBG108314	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108314&db=HOVERGEN
HPA	HPA002380	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA002380
InParanoid	P33527	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33527
IntAct	P33527	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33527*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR005292	http://www.ebi.ac.uk/interpro/entry/IPR005292
InterPro	IPR011527	http://www.ebi.ac.uk/interpro/entry/IPR011527
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
InterPro	IPR030241	http://www.ebi.ac.uk/interpro/entry/IPR030241
Jabion	4363	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=4363
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:4363	http://www.genome.jp/dbget-bin/www_bget?hsa:4363
KEGG_Orthology	KO:K05665	http://www.genome.jp/dbget-bin/www_bget?KO:K05665
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
KEGG_Pathway	ko04977	http://www.genome.jp/kegg-bin/show_pathway?ko04977
MIM	158343	http://www.ncbi.nlm.nih.gov/omim/158343
MINT	MINT-2802626	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-2802626
OMA	MFSGPQI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MFSGPQI
OrthoDB	EOG091G00IN	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00IN
PANTHER	PTHR24223:SF241	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24223:SF241
PDB	2CBZ	http://www.ebi.ac.uk/pdbe-srv/view/entry/2CBZ
PDB	4C3Z	http://www.ebi.ac.uk/pdbe-srv/view/entry/4C3Z
PDBsum	2CBZ	http://www.ebi.ac.uk/pdbsum/2CBZ
PDBsum	4C3Z	http://www.ebi.ac.uk/pdbsum/4C3Z
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PROSITE	PS50929	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929
PSORT	swissprot:MRP1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MRP1_HUMAN
PSORT-B	swissprot:MRP1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MRP1_HUMAN
PSORT2	swissprot:MRP1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MRP1_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF00664	http://pfam.xfam.org/family/PF00664
PharmGKB	PA244	http://www.pharmgkb.org/do/serve?objId=PA244&objCls=Gene
Phobius	swissprot:MRP1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MRP1_HUMAN
PhylomeDB	P33527	http://phylomedb.org/?seqid=P33527
ProteinModelPortal	P33527	http://www.proteinmodelportal.org/query/uniprot/P33527
PubMed	10064732	http://www.ncbi.nlm.nih.gov/pubmed/10064732
PubMed	10493829	http://www.ncbi.nlm.nih.gov/pubmed/10493829
PubMed	10811882	http://www.ncbi.nlm.nih.gov/pubmed/10811882
PubMed	10835642	http://www.ncbi.nlm.nih.gov/pubmed/10835642
PubMed	11114332	http://www.ncbi.nlm.nih.gov/pubmed/11114332
PubMed	11139250	http://www.ncbi.nlm.nih.gov/pubmed/11139250
PubMed	11266082	http://www.ncbi.nlm.nih.gov/pubmed/11266082
PubMed	11278596	http://www.ncbi.nlm.nih.gov/pubmed/11278596
PubMed	11278867	http://www.ncbi.nlm.nih.gov/pubmed/11278867
PubMed	11469806	http://www.ncbi.nlm.nih.gov/pubmed/11469806
PubMed	11721885	http://www.ncbi.nlm.nih.gov/pubmed/11721885
PubMed	1360704	http://www.ncbi.nlm.nih.gov/pubmed/1360704
PubMed	15208328	http://www.ncbi.nlm.nih.gov/pubmed/15208328
PubMed	15260484	http://www.ncbi.nlm.nih.gov/pubmed/15260484
PubMed	15616553	http://www.ncbi.nlm.nih.gov/pubmed/15616553
PubMed	16230346	http://www.ncbi.nlm.nih.gov/pubmed/16230346
PubMed	16697012	http://www.ncbi.nlm.nih.gov/pubmed/16697012
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	18987736	http://www.ncbi.nlm.nih.gov/pubmed/18987736
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	8098549	http://www.ncbi.nlm.nih.gov/pubmed/8098549
PubMed	9295302	http://www.ncbi.nlm.nih.gov/pubmed/9295302
PubMed	9334225	http://www.ncbi.nlm.nih.gov/pubmed/9334225
PubMed	9344662	http://www.ncbi.nlm.nih.gov/pubmed/9344662
PubMed	9485377	http://www.ncbi.nlm.nih.gov/pubmed/9485377
Reactome	R-HSA-196741	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-196741
Reactome	R-HSA-2142691	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2142691
Reactome	R-HSA-382556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-382556
RefSeq	NP_004987	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004987
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	P33527	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33527
STRING	9606.ENSP00000382342	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000382342&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
SUPFAM	SSF90123	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123
TCDB	3.A.1.208	http://www.tcdb.org/search/result.php?tc=3.A.1.208
TIGRFAMs	TIGR00957	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00957
UCSC	uc010bvi	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010bvi&org=rat
UniGene	Hs.391464	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.391464
UniProtKB	MRP1_HUMAN	http://www.uniprot.org/uniprot/MRP1_HUMAN
UniProtKB-AC	P33527	http://www.uniprot.org/uniprot/P33527
charge	swissprot:MRP1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MRP1_HUMAN
eggNOG	COG1132	http://eggnogapi.embl.de/nog_data/html/tree/COG1132
eggNOG	KOG0054	http://eggnogapi.embl.de/nog_data/html/tree/KOG0054
epestfind	swissprot:MRP1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MRP1_HUMAN
garnier	swissprot:MRP1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MRP1_HUMAN
helixturnhelix	swissprot:MRP1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MRP1_HUMAN
hmoment	swissprot:MRP1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MRP1_HUMAN
iep	swissprot:MRP1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MRP1_HUMAN
inforesidue	swissprot:MRP1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MRP1_HUMAN
neXtProt	NX_P33527	http://www.nextprot.org/db/entry/NX_P33527
octanol	swissprot:MRP1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MRP1_HUMAN
pepcoil	swissprot:MRP1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MRP1_HUMAN
pepdigest	swissprot:MRP1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MRP1_HUMAN
pepinfo	swissprot:MRP1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MRP1_HUMAN
pepnet	swissprot:MRP1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MRP1_HUMAN
pepstats	swissprot:MRP1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MRP1_HUMAN
pepwheel	swissprot:MRP1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MRP1_HUMAN
pepwindow	swissprot:MRP1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MRP1_HUMAN
sigcleave	swissprot:MRP1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MRP1_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNKF_HUMAN	Acid-sensitive potassium channel protein TASK-5
# AltName	KCNKF_HUMAN	TWIK-related acid-sensitive K(+) channel 5
# AltName	KCNKF_HUMAN	Two pore potassium channel KT3.3
# ChiTaRS	KCNK15	human
# Ensembl	ENST00000372861	ENSP00000361952; ENSG00000124249
# FUNCTION	KCNKF_HUMAN	Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0005267	potassium channel activity; TAS:Reactome.
# GO_function	GO:0022841	potassium ion leak channel activity; IBA:GO_Central.
# GO_process	GO:0030322	stabilization of membrane potential; IBA:GO_Central.
# GO_process	GO:0034765	regulation of ion transmembrane transport; IEA:UniProtKB-KW.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:0071805	potassium ion transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# HGNC	HGNC:13814	KCNK15
# InterPro	IPR003092	2pore_dom_K_chnl_TASK
# InterPro	IPR003280	2pore_dom_K_chnl
# InterPro	IPR008073	TASK5
# InterPro	IPR013099	K_chnl_dom
# KEGG_Brite	ko04040	Ion channels
# MIM	607368	gene
# Organism	KCNKF_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11003:SF18	PTHR11003:SF18
# PIR	JC7703	JC7703
# PIRSF	PIRSF038061	K_channel_subfamily_K_type
# POLYMORPHISM	KCNKF_HUMAN	Three variant polypeptides are known  TASK-5A, TASK- 5B and TASK-5C. The sequence shown is that of TASK-5C. {ECO 0000269|PubMed 11409881, ECO 0000269|PubMed 11749039, ECO 0000269|PubMed 11780052, ECO 0000269|PubMed 15489334}. 
# PRINTS	PR01095	TASKCHANNEL
# PRINTS	PR01333	2POREKCHANEL
# PRINTS	PR01690	TASK5CHANNEL
# Pfam	PF07885	Ion_trans_2; 2
# Proteomes	UP000005640	Chromosome 20
# Reactome	R-HSA-5576886	Phase 4 - resting membrane potential
# RecName	KCNKF_HUMAN	Potassium channel subfamily K member 15
# RefSeq	NP_071753	NM_022358.3
# SIMILARITY	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCNKF_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Heterodimer. {ECO	0000305}. 
# TCDB	1.A.1.9.12	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	KCNKF_HUMAN	Detected in pancreas, heart, placenta, lung, liver, kidney, ovary, testis, skeletal muscle and adrenal gland, and at lower levels in prostate, spleen and thyroid gland. {ECO 0000269|PubMed 11409881, ECO 0000269|PubMed 11680614}. 
# UCSC	uc002xmr	human
# eggNOG	ENOG410XRZJ	LUCA
# eggNOG	KOG4404	Eukaryota
BLAST	swissprot:KCNKF_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNKF_HUMAN
BioCyc	ZFISH:ENSG00000124249-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000124249-MONOMER
COXPRESdb	60598	http://coxpresdb.jp/data/gene/60598.shtml
CleanEx	HS_KCNK15	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNK15
DOI	10.1006/bbrc.2001.5064	http://dx.doi.org/10.1006/bbrc.2001.5064
DOI	10.1006/mcne.2001.1045	http://dx.doi.org/10.1006/mcne.2001.1045
DOI	10.1007/s004240100620	http://dx.doi.org/10.1007/s004240100620
DOI	10.1038/414865a	http://dx.doi.org/10.1038/414865a
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF257081	http://www.ebi.ac.uk/ena/data/view/AF257081
EMBL	AF294350	http://www.ebi.ac.uk/ena/data/view/AF294350
EMBL	AF294351	http://www.ebi.ac.uk/ena/data/view/AF294351
EMBL	AF294352	http://www.ebi.ac.uk/ena/data/view/AF294352
EMBL	AF336342	http://www.ebi.ac.uk/ena/data/view/AF336342
EMBL	AL118522	http://www.ebi.ac.uk/ena/data/view/AL118522
EMBL	BC093874	http://www.ebi.ac.uk/ena/data/view/BC093874
EMBL	BC143282	http://www.ebi.ac.uk/ena/data/view/BC143282
Ensembl	ENST00000372861	http://www.ensembl.org/id/ENST00000372861
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_function	GO:0022841	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022841
GO_process	GO:0030322	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030322
GO_process	GO:0034765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034765
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	KCNK15	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNK15
GeneID	60598	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=60598
H-InvDB	HIX0040517	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0040517
HGNC	HGNC:13814	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13814
HOGENOM	HOG000231463	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231463&db=HOGENOM6
HOVERGEN	HBG052239	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052239&db=HOVERGEN
HPA	HPA064861	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA064861
InParanoid	Q9H427	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9H427
InterPro	IPR003092	http://www.ebi.ac.uk/interpro/entry/IPR003092
InterPro	IPR003280	http://www.ebi.ac.uk/interpro/entry/IPR003280
InterPro	IPR008073	http://www.ebi.ac.uk/interpro/entry/IPR008073
InterPro	IPR013099	http://www.ebi.ac.uk/interpro/entry/IPR013099
Jabion	60598	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=60598
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:60598	http://www.genome.jp/dbget-bin/www_bget?hsa:60598
KEGG_Orthology	KO:K04923	http://www.genome.jp/dbget-bin/www_bget?KO:K04923
MIM	607368	http://www.ncbi.nlm.nih.gov/omim/607368
OrthoDB	EOG091G08DH	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08DH
PANTHER	PTHR11003:SF18	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11003:SF18
PRINTS	PR01095	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01095
PRINTS	PR01333	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01333
PRINTS	PR01690	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01690
PSORT	swissprot:KCNKF_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNKF_HUMAN
PSORT-B	swissprot:KCNKF_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNKF_HUMAN
PSORT2	swissprot:KCNKF_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNKF_HUMAN
Pfam	PF07885	http://pfam.xfam.org/family/PF07885
PharmGKB	PA30056	http://www.pharmgkb.org/do/serve?objId=PA30056&objCls=Gene
Phobius	swissprot:KCNKF_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNKF_HUMAN
PhylomeDB	Q9H427	http://phylomedb.org/?seqid=Q9H427
ProteinModelPortal	Q9H427	http://www.proteinmodelportal.org/query/uniprot/Q9H427
PubMed	11409881	http://www.ncbi.nlm.nih.gov/pubmed/11409881
PubMed	11431495	http://www.ncbi.nlm.nih.gov/pubmed/11431495
PubMed	11680614	http://www.ncbi.nlm.nih.gov/pubmed/11680614
PubMed	11749039	http://www.ncbi.nlm.nih.gov/pubmed/11749039
PubMed	11780052	http://www.ncbi.nlm.nih.gov/pubmed/11780052
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-5576886	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576886
RefSeq	NP_071753	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_071753
SMR	Q9H427	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9H427
STRING	9606.ENSP00000361952	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000361952&targetmode=cogs
TCDB	1.A.1.9.12	http://www.tcdb.org/search/result.php?tc=1.A.1.9.12
UCSC	uc002xmr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002xmr&org=rat
UniGene	Hs.528664	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.528664
UniProtKB	KCNKF_HUMAN	http://www.uniprot.org/uniprot/KCNKF_HUMAN
UniProtKB-AC	Q9H427	http://www.uniprot.org/uniprot/Q9H427
charge	swissprot:KCNKF_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNKF_HUMAN
eggNOG	ENOG410XRZJ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRZJ
eggNOG	KOG4404	http://eggnogapi.embl.de/nog_data/html/tree/KOG4404
epestfind	swissprot:KCNKF_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNKF_HUMAN
garnier	swissprot:KCNKF_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNKF_HUMAN
helixturnhelix	swissprot:KCNKF_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNKF_HUMAN
hmoment	swissprot:KCNKF_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNKF_HUMAN
iep	swissprot:KCNKF_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNKF_HUMAN
inforesidue	swissprot:KCNKF_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNKF_HUMAN
neXtProt	NX_Q9H427	http://www.nextprot.org/db/entry/NX_Q9H427
octanol	swissprot:KCNKF_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNKF_HUMAN
pepcoil	swissprot:KCNKF_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNKF_HUMAN
pepdigest	swissprot:KCNKF_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNKF_HUMAN
pepinfo	swissprot:KCNKF_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNKF_HUMAN
pepnet	swissprot:KCNKF_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNKF_HUMAN
pepstats	swissprot:KCNKF_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNKF_HUMAN
pepwheel	swissprot:KCNKF_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNKF_HUMAN
pepwindow	swissprot:KCNKF_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNKF_HUMAN
sigcleave	swissprot:KCNKF_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNKF_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	MRP9_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q96J65-1; Sequence=Displayed; Name=2; Synonyms=A, C, D; IsoId=Q96J65-2; Sequence=VSP_021084, VSP_021088, VSP_021092; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; Synonyms=B; IsoId=Q96J65-3; Sequence=VSP_021084, VSP_021088, VSP_021090, VSP_021091; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=4; IsoId=Q96J65-4; Sequence=VSP_021084, VSP_021086, VSP_021087; Note=No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=5; IsoId=Q96J65-5; Sequence=VSP_021084, VSP_021085, VSP_021089, VSP_021092; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 
# AltName	MRP9_HUMAN	ATP-binding cassette sub-family C member 12
# CCDS	CCDS10730	-. [Q96J65-1]
# DEVELOPMENTAL STAGE	Expressed in fetal tissues. {ECO:0000269|PubMed	11688999}. 
# Ensembl	ENST00000311303	ENSP00000311030; ENSG00000140798. [Q96J65-1]
# Ensembl	ENST00000497206	ENSP00000431232; ENSG00000140798. [Q96J65-2]
# Ensembl	ENST00000529084	ENSP00000434510; ENSG00000140798. [Q96J65-4]
# Ensembl	ENST00000529504	ENSP00000433333; ENSG00000140798. [Q96J65-3]
# Ensembl	ENST00000532494	ENSP00000437047; ENSG00000140798. [Q96J65-2]
# Ensembl	ENST00000534418	ENSP00000431354; ENSG00000140798. [Q96J65-5]
# ExpressionAtlas	Q96J65	baseline and differential
# FUNCTION	MRP9_HUMAN	Probable transporter. {ECO 0000250}. 
# GO_component	GO:0005739	mitochondrion; IEA:Ensembl.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# Gene3D	3.40.50.300	-; 2.
# Genevisible	Q96J65	HS
# HGNC	HGNC:14640	ABCC12
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR011527	ABC1_TM_dom
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR027417	P-loop_NTPase
# InterPro	IPR030250	MRP9
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko02010	ABC transporters
# MIM	607041	gene
# Organism	MRP9_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR24223:SF10	PTHR24223:SF10; 2
# PROSITE	PS00211	ABC_TRANSPORTER_1; 2
# PROSITE	PS50893	ABC_TRANSPORTER_2; 2
# PROSITE	PS50929	ABC_TM1F; 2
# Pfam	PF00005	ABC_tran; 2
# Pfam	PF00664	ABC_membrane; 2
# Proteomes	UP000005640	Chromosome 16
# RecName	MRP9_HUMAN	Multidrug resistance-associated protein 9
# RefSeq	NP_150229	NM_033226.2. [Q96J65-1]
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 2 ABC transmembrane type-1 domains. {ECO:0000255|PROSITE-ProRule	PRU00441}. 
# SIMILARITY	Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA; 2
# SUBCELLULAR LOCATION	MRP9_HUMAN	Membrane {ECO 0000255|PROSITE- ProRule PRU00441}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00441}. 
# SUPFAM	SSF52540	SSF52540; 2
# SUPFAM	SSF90123	SSF90123; 2
# TCDB	3.A.1.208.29	the atp-binding cassette (abc) superfamily
# TISSUE SPECIFICITY	MRP9_HUMAN	Expressed in testis (at protein level). Widely expressed at low level. Isoform 5 is specifically expressed in brain, testis and breast cancer cells. {ECO 0000269|PubMed 11483364, ECO 0000269|PubMed 11688999, ECO 0000269|PubMed 12011458}. 
# UCSC	uc002efc	human. [Q96J65-1]
# WEB RESOURCE	MRP9_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=Q96J65";
# eggNOG	COG1132	LUCA
# eggNOG	KOG0054	Eukaryota
BLAST	swissprot:MRP9_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MRP9_HUMAN
COXPRESdb	94160	http://coxpresdb.jp/data/gene/94160.shtml
CleanEx	HS_ABCC12	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCC12
DOI	10.1006/bbrc.2001.5865	http://dx.doi.org/10.1006/bbrc.2001.5865
DOI	10.1016/S0378-1119(01)00572-8	http://dx.doi.org/10.1016/S0378-1119(01)00572-8
DOI	10.1038/nature03187	http://dx.doi.org/10.1038/nature03187
DOI	10.1073/pnas.102187299	http://dx.doi.org/10.1073/pnas.102187299
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC096996	http://www.ebi.ac.uk/ena/data/view/AC096996
EMBL	AF395908	http://www.ebi.ac.uk/ena/data/view/AF395908
EMBL	AF395909	http://www.ebi.ac.uk/ena/data/view/AF395909
EMBL	AF411577	http://www.ebi.ac.uk/ena/data/view/AF411577
EMBL	AF411578	http://www.ebi.ac.uk/ena/data/view/AF411578
EMBL	AY040220	http://www.ebi.ac.uk/ena/data/view/AY040220
EMBL	AY196326	http://www.ebi.ac.uk/ena/data/view/AY196326
EMBL	BC036378	http://www.ebi.ac.uk/ena/data/view/BC036378
Ensembl	ENST00000311303	http://www.ensembl.org/id/ENST00000311303
Ensembl	ENST00000497206	http://www.ensembl.org/id/ENST00000497206
Ensembl	ENST00000529084	http://www.ensembl.org/id/ENST00000529084
Ensembl	ENST00000529504	http://www.ensembl.org/id/ENST00000529504
Ensembl	ENST00000532494	http://www.ensembl.org/id/ENST00000532494
Ensembl	ENST00000534418	http://www.ensembl.org/id/ENST00000534418
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCC12	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCC12
GeneID	94160	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=94160
GeneTree	ENSGT00860000133722	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00860000133722
H-InvDB	HIX0026945	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0026945
HGNC	HGNC:14640	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14640
HOVERGEN	HBG108314	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108314&db=HOVERGEN
HPA	HPA043100	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA043100
InParanoid	Q96J65	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96J65
IntAct	Q96J65	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96J65*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR011527	http://www.ebi.ac.uk/interpro/entry/IPR011527
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
InterPro	IPR030250	http://www.ebi.ac.uk/interpro/entry/IPR030250
Jabion	94160	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=94160
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:94160	http://www.genome.jp/dbget-bin/www_bget?hsa:94160
KEGG_Orthology	KO:K05672	http://www.genome.jp/dbget-bin/www_bget?KO:K05672
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
MIM	607041	http://www.ncbi.nlm.nih.gov/omim/607041
OMA	VPECTHP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VPECTHP
OrthoDB	EOG091G01TC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01TC
PANTHER	PTHR24223:SF10	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24223:SF10
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PROSITE	PS50929	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929
PSORT	swissprot:MRP9_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MRP9_HUMAN
PSORT-B	swissprot:MRP9_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MRP9_HUMAN
PSORT2	swissprot:MRP9_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MRP9_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF00664	http://pfam.xfam.org/family/PF00664
PharmGKB	PA24394	http://www.pharmgkb.org/do/serve?objId=PA24394&objCls=Gene
Phobius	swissprot:MRP9_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MRP9_HUMAN
PhylomeDB	Q96J65	http://phylomedb.org/?seqid=Q96J65
ProteinModelPortal	Q96J65	http://www.proteinmodelportal.org/query/uniprot/Q96J65
PubMed	11483364	http://www.ncbi.nlm.nih.gov/pubmed/11483364
PubMed	11688999	http://www.ncbi.nlm.nih.gov/pubmed/11688999
PubMed	12011458	http://www.ncbi.nlm.nih.gov/pubmed/12011458
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15616553	http://www.ncbi.nlm.nih.gov/pubmed/15616553
RefSeq	NP_150229	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_150229
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	Q96J65	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q96J65
STRING	9606.ENSP00000311030	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000311030&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
SUPFAM	SSF90123	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123
TCDB	3.A.1.208.29	http://www.tcdb.org/search/result.php?tc=3.A.1.208.29
UCSC	uc002efc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002efc&org=rat
UniGene	Hs.410111	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.410111
UniProtKB	MRP9_HUMAN	http://www.uniprot.org/uniprot/MRP9_HUMAN
UniProtKB-AC	Q96J65	http://www.uniprot.org/uniprot/Q96J65
charge	swissprot:MRP9_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MRP9_HUMAN
eggNOG	COG1132	http://eggnogapi.embl.de/nog_data/html/tree/COG1132
eggNOG	KOG0054	http://eggnogapi.embl.de/nog_data/html/tree/KOG0054
epestfind	swissprot:MRP9_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MRP9_HUMAN
garnier	swissprot:MRP9_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MRP9_HUMAN
helixturnhelix	swissprot:MRP9_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MRP9_HUMAN
hmoment	swissprot:MRP9_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MRP9_HUMAN
iep	swissprot:MRP9_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MRP9_HUMAN
inforesidue	swissprot:MRP9_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MRP9_HUMAN
neXtProt	NX_Q96J65	http://www.nextprot.org/db/entry/NX_Q96J65
octanol	swissprot:MRP9_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MRP9_HUMAN
pepcoil	swissprot:MRP9_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MRP9_HUMAN
pepdigest	swissprot:MRP9_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MRP9_HUMAN
pepinfo	swissprot:MRP9_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MRP9_HUMAN
pepnet	swissprot:MRP9_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MRP9_HUMAN
pepstats	swissprot:MRP9_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MRP9_HUMAN
pepwheel	swissprot:MRP9_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MRP9_HUMAN
pepwindow	swissprot:MRP9_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MRP9_HUMAN
sigcleave	swissprot:MRP9_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MRP9_HUMAN
## Database	ID	URL or Descriptions
# DOMAIN	AQP8_HUMAN	Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). 
# Ensembl	ENST00000219660	ENSP00000219660; ENSG00000103375
# ExpressionAtlas	O94778	baseline and differential
# FUNCTION	AQP8_HUMAN	Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0045177	apical part of cell; IDA:UniProtKB.
# GO_function	GO:0015250	water channel activity; EXP:Reactome.
# GO_function	GO:0015254	glycerol channel activity; IBA:GO_Central.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006833	water transport; TAS:Reactome.
# GO_process	GO:0009992	cellular water homeostasis; IBA:GO_Central.
# GO_process	GO:0034220	ion transmembrane transport; IBA:GO_Central.
# GO_process	GO:0071320	cellular response to cAMP; IEP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.1080.10	-; 1.
# Genevisible	O94778	HS
# HGNC	HGNC:642	AQP8
# InterPro	IPR000425	MIP
# InterPro	IPR022357	MIP_CS
# InterPro	IPR023271	Aquaporin-like
# InterPro	IPR023277	Aquaporin_8
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04976	Bile secretion
# MIM	603750	gene
# Organism	AQP8_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR19139	PTHR19139
# PRINTS	PR00783	MINTRINSICP
# PRINTS	PR02020	AQUAPORIN8
# PROSITE	PS00221	MIP
# Pfam	PF00230	MIP
# Proteomes	UP000005640	Chromosome 16
# Reactome	R-HSA-3299685	Detoxification of Reactive Oxygen Species
# Reactome	R-HSA-432047	Passive transport by Aquaporins
# RecName	AQP8_HUMAN	Aquaporin-8
# RefSeq	NP_001160	NM_001169.2
# SIMILARITY	Belongs to the MIP/aquaporin (TC 1.A.8) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	AQP8_HUMAN	Membrane; Multi-pass membrane protein. 
# SUPFAM	SSF81338	SSF81338
# TCDB	1.A.8.16	the major intrinsic protein (mip) family
# TISSUE SPECIFICITY	AQP8_HUMAN	Expressed only in pancreas and colon. 
# UCSC	uc002doc	human
# eggNOG	COG0580	LUCA
# eggNOG	KOG0223	Eukaryota
BLAST	swissprot:AQP8_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AQP8_HUMAN
BioCyc	ZFISH:ENSG00000103375-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000103375-MONOMER
COXPRESdb	343	http://coxpresdb.jp/data/gene/343.shtml
CleanEx	HS_AQP8	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AQP8
DOI	10.1006/geno.1998.5552	http://dx.doi.org/10.1006/geno.1998.5552
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
EMBL	AB013456	http://www.ebi.ac.uk/ena/data/view/AB013456
EMBL	AF067797	http://www.ebi.ac.uk/ena/data/view/AF067797
EMBL	BC040630	http://www.ebi.ac.uk/ena/data/view/BC040630
Ensembl	ENST00000219660	http://www.ensembl.org/id/ENST00000219660
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0045177	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045177
GO_function	GO:0015250	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015250
GO_function	GO:0015254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015254
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006833	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006833
GO_process	GO:0009992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009992
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0071320	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071320
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.1080.10	http://www.cathdb.info/version/latest/superfamily/1.20.1080.10
GeneCards	AQP8	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=AQP8
GeneID	343	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=343
GeneTree	ENSGT00760000119223	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119223
HGNC	HGNC:642	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:642
HOGENOM	HOG000288286	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000288286&db=HOGENOM6
HOVERGEN	HBG100478	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG100478&db=HOVERGEN
HPA	HPA046259	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA046259
InParanoid	O94778	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O94778
InterPro	IPR000425	http://www.ebi.ac.uk/interpro/entry/IPR000425
InterPro	IPR022357	http://www.ebi.ac.uk/interpro/entry/IPR022357
InterPro	IPR023271	http://www.ebi.ac.uk/interpro/entry/IPR023271
InterPro	IPR023277	http://www.ebi.ac.uk/interpro/entry/IPR023277
Jabion	343	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=343
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:343	http://www.genome.jp/dbget-bin/www_bget?hsa:343
KEGG_Orthology	KO:K09869	http://www.genome.jp/dbget-bin/www_bget?KO:K09869
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
MIM	603750	http://www.ncbi.nlm.nih.gov/omim/603750
OMA	WYERLVQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WYERLVQ
OrthoDB	EOG091G166T	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G166T
PANTHER	PTHR19139	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19139
PRINTS	PR00783	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00783
PRINTS	PR02020	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR02020
PROSITE	PS00221	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00221
PSORT	swissprot:AQP8_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AQP8_HUMAN
PSORT-B	swissprot:AQP8_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AQP8_HUMAN
PSORT2	swissprot:AQP8_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AQP8_HUMAN
Pfam	PF00230	http://pfam.xfam.org/family/PF00230
PharmGKB	PA24926	http://www.pharmgkb.org/do/serve?objId=PA24926&objCls=Gene
Phobius	swissprot:AQP8_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AQP8_HUMAN
PhylomeDB	O94778	http://phylomedb.org/?seqid=O94778
ProteinModelPortal	O94778	http://www.proteinmodelportal.org/query/uniprot/O94778
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	9806845	http://www.ncbi.nlm.nih.gov/pubmed/9806845
Reactome	R-HSA-3299685	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3299685
Reactome	R-HSA-432047	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432047
RefSeq	NP_001160	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001160
SMR	O94778	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O94778
STRING	9606.ENSP00000219660	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000219660&targetmode=cogs
SUPFAM	SSF81338	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81338
TCDB	1.A.8.16	http://www.tcdb.org/search/result.php?tc=1.A.8.16
UCSC	uc002doc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002doc&org=rat
UniGene	Hs.176658	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.176658
UniProtKB	AQP8_HUMAN	http://www.uniprot.org/uniprot/AQP8_HUMAN
UniProtKB-AC	O94778	http://www.uniprot.org/uniprot/O94778
charge	swissprot:AQP8_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AQP8_HUMAN
eggNOG	COG0580	http://eggnogapi.embl.de/nog_data/html/tree/COG0580
eggNOG	KOG0223	http://eggnogapi.embl.de/nog_data/html/tree/KOG0223
epestfind	swissprot:AQP8_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AQP8_HUMAN
garnier	swissprot:AQP8_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AQP8_HUMAN
helixturnhelix	swissprot:AQP8_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AQP8_HUMAN
hmoment	swissprot:AQP8_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AQP8_HUMAN
iep	swissprot:AQP8_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AQP8_HUMAN
inforesidue	swissprot:AQP8_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AQP8_HUMAN
neXtProt	NX_O94778	http://www.nextprot.org/db/entry/NX_O94778
octanol	swissprot:AQP8_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AQP8_HUMAN
pepcoil	swissprot:AQP8_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AQP8_HUMAN
pepdigest	swissprot:AQP8_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AQP8_HUMAN
pepinfo	swissprot:AQP8_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AQP8_HUMAN
pepnet	swissprot:AQP8_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AQP8_HUMAN
pepstats	swissprot:AQP8_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AQP8_HUMAN
pepwheel	swissprot:AQP8_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AQP8_HUMAN
pepwindow	swissprot:AQP8_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AQP8_HUMAN
sigcleave	swissprot:AQP8_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AQP8_HUMAN
## Database	ID	URL or Descriptions
# CAUTION	Could be the product of a pseudogene. {ECO	0000305}.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005216	ion channel activity; IEA:InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# HGNC	HGNC:31124	FXYD6P3
# InterPro	IPR000272	Ion-transport_regulator_FXYD
# Organism	FXYD8_HUMAN	Homo sapiens (Human)
# PROSITE	PS01310	FXYD
# Pfam	PF02038	ATP1G1_PLM_MAT8
# ProDom	PD005989	PD005989
# Proteomes	UP000005640	Unplaced
# RecName	FXYD8_HUMAN	Putative FXYD domain-containing ion transport regulator 8
# SIMILARITY	Belongs to the FXYD family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	FXYD8_HUMAN	Membrane {ECO 0000305}; Single-pass type I membrane protein {ECO 0000305}. 
BLAST	swissprot:FXYD8_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:FXYD8_HUMAN
BioCyc	ZFISH:G66-30904-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-30904-MONOMER
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
EMBL	AL353804	http://www.ebi.ac.uk/ena/data/view/AL353804
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005216	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005216
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GeneCards	FXYD6P3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=FXYD6P3
HGNC	HGNC:31124	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:31124
HOVERGEN	HBG008212	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG008212&db=HOVERGEN
HPA	HPA041334	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA041334
InParanoid	P58550	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P58550
InterPro	IPR000272	http://www.ebi.ac.uk/interpro/entry/IPR000272
PROSITE	PS01310	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01310
PSORT	swissprot:FXYD8_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:FXYD8_HUMAN
PSORT-B	swissprot:FXYD8_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:FXYD8_HUMAN
PSORT2	swissprot:FXYD8_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:FXYD8_HUMAN
Pfam	PF02038	http://pfam.xfam.org/family/PF02038
Phobius	swissprot:FXYD8_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:FXYD8_HUMAN
PhylomeDB	P58550	http://phylomedb.org/?seqid=P58550
ProteinModelPortal	P58550	http://www.proteinmodelportal.org/query/uniprot/P58550
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
SMR	P58550	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P58550
UniProtKB	FXYD8_HUMAN	http://www.uniprot.org/uniprot/FXYD8_HUMAN
UniProtKB-AC	P58550	http://www.uniprot.org/uniprot/P58550
charge	swissprot:FXYD8_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:FXYD8_HUMAN
epestfind	swissprot:FXYD8_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:FXYD8_HUMAN
garnier	swissprot:FXYD8_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:FXYD8_HUMAN
helixturnhelix	swissprot:FXYD8_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:FXYD8_HUMAN
hmoment	swissprot:FXYD8_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:FXYD8_HUMAN
iep	swissprot:FXYD8_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:FXYD8_HUMAN
inforesidue	swissprot:FXYD8_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:FXYD8_HUMAN
neXtProt	NX_P58550	http://www.nextprot.org/db/entry/NX_P58550
octanol	swissprot:FXYD8_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:FXYD8_HUMAN
pepcoil	swissprot:FXYD8_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:FXYD8_HUMAN
pepdigest	swissprot:FXYD8_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:FXYD8_HUMAN
pepinfo	swissprot:FXYD8_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:FXYD8_HUMAN
pepnet	swissprot:FXYD8_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:FXYD8_HUMAN
pepstats	swissprot:FXYD8_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:FXYD8_HUMAN
pepwheel	swissprot:FXYD8_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:FXYD8_HUMAN
pepwindow	swissprot:FXYD8_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:FXYD8_HUMAN
sigcleave	swissprot:FXYD8_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:FXYD8_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNT2_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q6UVM3-1; Sequence=Displayed; Name=2; IsoId=Q6UVM3-2; Sequence=VSP_029855; Name=3; IsoId=Q6UVM3-3; Sequence=VSP_029854, VSP_029855, VSP_029856; Name=4; IsoId=Q6UVM3-4; Sequence=VSP_029852, VSP_029853, VSP_029855, VSP_029856, VSP_029857; 
# AltName	KCNT2_HUMAN	Sequence like an intermediate conductance potassium channel subunit
# AltName	KCNT2_HUMAN	Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1
# BioGrid	131252	8
# CCDS	CCDS1384	-. [Q6UVM3-1]
# CCDS	CCDS72994	-. [Q6UVM3-3]
# CCDS	CCDS72995	-. [Q6UVM3-2]
# ChiTaRS	KCNT2	human
# Ensembl	ENST00000294725	ENSP00000294725; ENSG00000162687. [Q6UVM3-1]
# Ensembl	ENST00000367433	ENSP00000356403; ENSG00000162687. [Q6UVM3-2]
# Ensembl	ENST00000609185	ENSP00000476657; ENSG00000162687. [Q6UVM3-3]
# ExpressionAtlas	Q6UVM3	baseline and differential
# FUNCTION	KCNT2_HUMAN	Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. Activated by high intracellular sodium and chloride levels. Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane (By similarity). Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. {ECO 0000250, ECO 0000269|PubMed 14684870, ECO 0000269|PubMed 16687497}. 
# GO_component	GO:0008076	voltage-gated potassium channel complex; IBA:GO_Central.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IBA:GO_Central.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0015269	calcium-activated potassium channel activity; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# Gene3D	3.40.50.720	-; 2.
# Genevisible	Q6UVM3	HS
# HGNC	HGNC:18866	KCNT2
# InterPro	IPR003929	K_chnl_Ca-activ_BK_asu
# InterPro	IPR013099	K_chnl_dom
# InterPro	IPR016040	NAD(P)-bd_dom
# KEGG_Brite	ko04040	Ion channels
# MIM	610044	gene
# Organism	KCNT2_HUMAN	Homo sapiens (Human)
# PTM	KCNT2_HUMAN	Phosphorylated by protein kinase C. Phosphorylation of the C- terminal domain inhibits channel activity. {ECO 0000269|PubMed 16687497}. 
# Pfam	PF03493	BK_channel_a
# Pfam	PF07885	Ion_trans_2
# Proteomes	UP000005640	Chromosome 1
# RecName	KCNT2_HUMAN	Potassium channel subfamily T member 2
# RefSeq	NP_001274748	NM_001287819.1. [Q6UVM3-2]
# RefSeq	NP_001274749	NM_001287820.1. [Q6UVM3-3]
# RefSeq	NP_940905	NM_198503.3. [Q6UVM3-1]
# SIMILARITY	Belongs to the potassium channel family. Calcium- activated (TC 1.A.1.3) subfamily. KCa4.2/KCNT2 sub-subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 RCK N-terminal domain. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCNT2_HUMAN	Cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUPFAM	SSF51735	SSF51735
# TCDB	1.A.1.3	the voltage-gated ion channel (vic) superfamily
# UCSC	uc001gtd	human. [Q6UVM3-1]
# eggNOG	ENOG410XSMA	LUCA
# eggNOG	KOG3193	Eukaryota
BLAST	swissprot:KCNT2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNT2_HUMAN
COXPRESdb	343450	http://coxpresdb.jp/data/gene/343450.shtml
CleanEx	HS_KCNT2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNT2
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.1523/JNEUROSCI.3372-05.2006	http://dx.doi.org/10.1523/JNEUROSCI.3372-05.2006
EMBL	AK131498	http://www.ebi.ac.uk/ena/data/view/AK131498
EMBL	AL138931	http://www.ebi.ac.uk/ena/data/view/AL138931
EMBL	AL138931	http://www.ebi.ac.uk/ena/data/view/AL138931
EMBL	AL138931	http://www.ebi.ac.uk/ena/data/view/AL138931
EMBL	AL138931	http://www.ebi.ac.uk/ena/data/view/AL138931
EMBL	AL138931	http://www.ebi.ac.uk/ena/data/view/AL138931
EMBL	AL138931	http://www.ebi.ac.uk/ena/data/view/AL138931
EMBL	AL138931	http://www.ebi.ac.uk/ena/data/view/AL138931
EMBL	AL138931	http://www.ebi.ac.uk/ena/data/view/AL138931
EMBL	AL139137	http://www.ebi.ac.uk/ena/data/view/AL139137
EMBL	AL139137	http://www.ebi.ac.uk/ena/data/view/AL139137
EMBL	AL139137	http://www.ebi.ac.uk/ena/data/view/AL139137
EMBL	AL139137	http://www.ebi.ac.uk/ena/data/view/AL139137
EMBL	AL139137	http://www.ebi.ac.uk/ena/data/view/AL139137
EMBL	AL139137	http://www.ebi.ac.uk/ena/data/view/AL139137
EMBL	AL139137	http://www.ebi.ac.uk/ena/data/view/AL139137
EMBL	AL139137	http://www.ebi.ac.uk/ena/data/view/AL139137
EMBL	AL358853	http://www.ebi.ac.uk/ena/data/view/AL358853
EMBL	AL358853	http://www.ebi.ac.uk/ena/data/view/AL358853
EMBL	AL358853	http://www.ebi.ac.uk/ena/data/view/AL358853
EMBL	AL358853	http://www.ebi.ac.uk/ena/data/view/AL358853
EMBL	AL358853	http://www.ebi.ac.uk/ena/data/view/AL358853
EMBL	AL358853	http://www.ebi.ac.uk/ena/data/view/AL358853
EMBL	AL358853	http://www.ebi.ac.uk/ena/data/view/AL358853
EMBL	AL358853	http://www.ebi.ac.uk/ena/data/view/AL358853
EMBL	AL591604	http://www.ebi.ac.uk/ena/data/view/AL591604
EMBL	AL591604	http://www.ebi.ac.uk/ena/data/view/AL591604
EMBL	AL591604	http://www.ebi.ac.uk/ena/data/view/AL591604
EMBL	AL591604	http://www.ebi.ac.uk/ena/data/view/AL591604
EMBL	AL591604	http://www.ebi.ac.uk/ena/data/view/AL591604
EMBL	AL591604	http://www.ebi.ac.uk/ena/data/view/AL591604
EMBL	AL591604	http://www.ebi.ac.uk/ena/data/view/AL591604
EMBL	AL591604	http://www.ebi.ac.uk/ena/data/view/AL591604
EMBL	AY359444	http://www.ebi.ac.uk/ena/data/view/AY359444
EMBL	BC103948	http://www.ebi.ac.uk/ena/data/view/BC103948
EMBL	BC103949	http://www.ebi.ac.uk/ena/data/view/BC103949
EMBL	BC103950	http://www.ebi.ac.uk/ena/data/view/BC103950
EMBL	BX647852	http://www.ebi.ac.uk/ena/data/view/BX647852
Ensembl	ENST00000294725	http://www.ensembl.org/id/ENST00000294725
Ensembl	ENST00000367433	http://www.ensembl.org/id/ENST00000367433
Ensembl	ENST00000609185	http://www.ensembl.org/id/ENST00000609185
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0015269	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015269
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
Gene3D	3.40.50.720	http://www.cathdb.info/version/latest/superfamily/3.40.50.720
GeneCards	KCNT2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNT2
GeneID	343450	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=343450
GeneTree	ENSGT00530000063026	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063026
HGNC	HGNC:18866	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18866
HOGENOM	HOG000231460	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231460&db=HOGENOM6
HOVERGEN	HBG055190	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG055190&db=HOVERGEN
HPA	HPA051218	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA051218
InParanoid	Q6UVM3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6UVM3
InterPro	IPR003929	http://www.ebi.ac.uk/interpro/entry/IPR003929
InterPro	IPR013099	http://www.ebi.ac.uk/interpro/entry/IPR013099
InterPro	IPR016040	http://www.ebi.ac.uk/interpro/entry/IPR016040
Jabion	343450	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=343450
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:343450	http://www.genome.jp/dbget-bin/www_bget?hsa:343450
KEGG_Orthology	KO:K04947	http://www.genome.jp/dbget-bin/www_bget?KO:K04947
MIM	610044	http://www.ncbi.nlm.nih.gov/omim/610044
OMA	GPRYIMS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GPRYIMS
OrthoDB	EOG091G011O	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G011O
PSORT	swissprot:KCNT2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNT2_HUMAN
PSORT-B	swissprot:KCNT2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNT2_HUMAN
PSORT2	swissprot:KCNT2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNT2_HUMAN
Pfam	PF03493	http://pfam.xfam.org/family/PF03493
Pfam	PF07885	http://pfam.xfam.org/family/PF07885
PharmGKB	PA38726	http://www.pharmgkb.org/do/serve?objId=PA38726&objCls=Gene
Phobius	swissprot:KCNT2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNT2_HUMAN
PhylomeDB	Q6UVM3	http://phylomedb.org/?seqid=Q6UVM3
ProteinModelPortal	Q6UVM3	http://www.proteinmodelportal.org/query/uniprot/Q6UVM3
PubMed	14684870	http://www.ncbi.nlm.nih.gov/pubmed/14684870
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16687497	http://www.ncbi.nlm.nih.gov/pubmed/16687497
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
RefSeq	NP_001274748	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001274748
RefSeq	NP_001274749	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001274749
RefSeq	NP_940905	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_940905
STRING	9606.ENSP00000294725	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000294725&targetmode=cogs
SUPFAM	SSF51735	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735
TCDB	1.A.1.3	http://www.tcdb.org/search/result.php?tc=1.A.1.3
UCSC	uc001gtd	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001gtd&org=rat
UniGene	Hs.657046	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.657046
UniProtKB	KCNT2_HUMAN	http://www.uniprot.org/uniprot/KCNT2_HUMAN
UniProtKB-AC	Q6UVM3	http://www.uniprot.org/uniprot/Q6UVM3
charge	swissprot:KCNT2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNT2_HUMAN
eggNOG	ENOG410XSMA	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSMA
eggNOG	KOG3193	http://eggnogapi.embl.de/nog_data/html/tree/KOG3193
epestfind	swissprot:KCNT2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNT2_HUMAN
garnier	swissprot:KCNT2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNT2_HUMAN
helixturnhelix	swissprot:KCNT2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNT2_HUMAN
hmoment	swissprot:KCNT2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNT2_HUMAN
iep	swissprot:KCNT2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNT2_HUMAN
inforesidue	swissprot:KCNT2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNT2_HUMAN
neXtProt	NX_Q6UVM3	http://www.nextprot.org/db/entry/NX_Q6UVM3
octanol	swissprot:KCNT2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNT2_HUMAN
pepcoil	swissprot:KCNT2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNT2_HUMAN
pepdigest	swissprot:KCNT2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNT2_HUMAN
pepinfo	swissprot:KCNT2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNT2_HUMAN
pepnet	swissprot:KCNT2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNT2_HUMAN
pepstats	swissprot:KCNT2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNT2_HUMAN
pepwheel	swissprot:KCNT2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNT2_HUMAN
pepwindow	swissprot:KCNT2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNT2_HUMAN
sigcleave	swissprot:KCNT2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNT2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ATP7B_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=A; IsoId=P35670-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=P35670-2; Sequence=VSP_000426, VSP_000427; Name=3; IsoId=P35670-3; Sequence=VSP_016559; Name=4; IsoId=P35670-4; Sequence=VSP_016560; Note=No experimental confirmation available.; 
# AltName	ATP7B_HUMAN	Copper pump 2
# AltName	ATP7B_HUMAN	Wilson disease-associated protein
# AltName	ATP7B_HUMAN	Wilson disease-associated protein
# BRENDA	3.6.3	2681
# BioGrid	107022	17
# CATALYTIC ACTIVITY	ATP + H(2)O + Cu(+)(Side 1) = ADP + phosphate + Cu(+)(Side 2). {ECO:0000269|PubMed	22240481}. 
# CCDS	CCDS41892	-. [P35670-1]
# CCDS	CCDS45049	-. [P35670-2]
# CCDS	CCDS58293	-. [P35670-3]
# CDD	cd00371	HMA; 6
# DISEASE	ATP7B_HUMAN	Wilson disease (WD) [MIM 277900]  An autosomal recessive disorder of copper metabolism in which copper cannot be incorporated into ceruloplasmin in liver, and cannot be excreted from the liver into the bile. Copper accumulates in the liver and subsequently in the brain and kidney. The disease is characterized by neurologic manifestations and signs of cirrhosis. {ECO 0000269|PubMed 10051024, ECO 0000269|PubMed 10194254, ECO 0000269|PubMed 10447265, ECO 0000269|PubMed 10453196, ECO 0000269|PubMed 10502776, ECO 0000269|PubMed 10502777, ECO 0000269|PubMed 10544227, ECO 0000269|PubMed 10721669, ECO 0000269|PubMed 10790207, ECO 0000269|PubMed 11043508, ECO 0000269|PubMed 11093740, ECO 0000269|PubMed 11180609, ECO 0000269|PubMed 11216666, ECO 0000269|PubMed 11231950, ECO 0000269|PubMed 11243728, ECO 0000269|PubMed 11405812, ECO 0000269|PubMed 11690702, ECO 0000269|PubMed 11954751, ECO 0000269|PubMed 12325021, ECO 0000269|PubMed 12376745, ECO 0000269|PubMed 12544487, ECO 0000269|PubMed 14639035, ECO 0000269|PubMed 14966923, ECO 0000269|PubMed 14986826, ECO 0000269|PubMed 15024742, ECO 0000269|PubMed 15557537, ECO 0000269|PubMed 15811015, ECO 0000269|PubMed 15845031, ECO 0000269|PubMed 15952988, ECO 0000269|PubMed 15967699, ECO 0000269|PubMed 16088907, ECO 0000269|PubMed 16207219, ECO 0000269|PubMed 16283883, ECO 0000269|PubMed 16649058, ECO 0000269|PubMed 17718866, ECO 0000269|PubMed 17823867, ECO 0000269|PubMed 17919502, ECO 0000269|PubMed 17949296, ECO 0000269|PubMed 18373411, ECO 0000269|PubMed 21398519, ECO 0000269|PubMed 21454443, ECO 0000269|PubMed 21645214, ECO 0000269|PubMed 21682854, ECO 0000269|PubMed 22075048, ECO 0000269|PubMed 22240481, ECO 0000269|PubMed 22484412, ECO 0000269|PubMed 23235335, ECO 0000269|PubMed 23275100, ECO 0000269|PubMed 23333878, ECO 0000269|PubMed 23518715, ECO 0000269|PubMed 24706876, ECO 0000269|PubMed 25982861, ECO 0000269|PubMed 7626145, ECO 0000269|PubMed 8298641, ECO 0000269|PubMed 8533760, ECO 0000269|PubMed 8782057, ECO 0000269|PubMed 8931691, ECO 0000269|PubMed 8938442, ECO 0000269|PubMed 8980283, ECO 0000269|PubMed 9222767, ECO 0000269|PubMed 9311736, ECO 0000269|PubMed 9452121, ECO 0000269|PubMed 9482578, ECO 0000269|PubMed 9554743, ECO 0000269|PubMed 9671269, ECO 0000269|PubMed 9772425, ECO 0000269|PubMed 9829905, ECO 0000269|PubMed 9837819, ECO 0000269|PubMed 9887381}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	ATP7B_HUMAN	Each HMA domain can bind a copper ion, they are tightly packed and closely interact with each other. Wild-type ATP7B can usually be loaded with an average 5.5 copper atoms per molecule. {ECO 0000269|PubMed 20032459}. 
# DrugBank	DB00515	Cisplatin
# DrugBank	DB00526	Oxaliplatin
# DrugBank	DB00958	Carboplatin
# Ensembl	ENST00000242839	ENSP00000242839; ENSG00000123191. [P35670-1]
# Ensembl	ENST00000344297	ENSP00000342559; ENSG00000123191. [P35670-2]
# Ensembl	ENST00000400366	ENSP00000383217; ENSG00000123191. [P35670-3]
# ExpressionAtlas	P35670	baseline and differential
# FUNCTION	ATP7B_HUMAN	Involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile. {ECO 0000269|PubMed 18203200, ECO 0000269|PubMed 22240481, ECO 0000269|PubMed 24706876}. 
# GO_component	GO:0000139	Golgi membrane; TAS:Reactome.
# GO_component	GO:0005739	mitochondrion; IEA:UniProtKB-SubCell.
# GO_component	GO:0005770	late endosome; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:UniProtKB.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0032588	trans-Golgi network membrane; IDA:UniProtKB.
# GO_function	GO:0004008	copper-exporting ATPase activity; NAS:UniProtKB.
# GO_function	GO:0005507	copper ion binding; IDA:UniProtKB.
# GO_function	GO:0005524	ATP binding; IDA:UniProtKB.
# GO_function	GO:0043682	copper-transporting ATPase activity; IMP:UniProtKB.
# GO_process	GO:0006825	copper ion transport; IMP:UniProtKB.
# GO_process	GO:0006878	cellular copper ion homeostasis; TAS:UniProtKB.
# GO_process	GO:0006882	cellular zinc ion homeostasis; IEA:Ensembl.
# GO_process	GO:0007595	lactation; IEA:Ensembl.
# GO_process	GO:0015677	copper ion import; IDA:UniProtKB.
# GO_process	GO:0015680	intracellular copper ion transport; IEA:Ensembl.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0046688	response to copper ion; IDA:UniProtKB.
# GO_process	GO:0051208	sequestering of calcium ion; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005768	endosome
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.70.150.10	-; 1.
# Gene3D	3.40.1110.10	-; 2.
# Gene3D	3.40.50.1000	-; 2.
# Genevisible	P35670	HS
# HGNC	HGNC:870	ATP7B
# InterPro	IPR001757	P_typ_ATPase
# InterPro	IPR006121	HMA_dom
# InterPro	IPR006122	HMA_Cu_ion-bd
# InterPro	IPR008250	ATPase_P-typ_transduc_dom_A
# InterPro	IPR017969	Heavy-metal-associated_CS
# InterPro	IPR018303	ATPase_P-typ_P_site
# InterPro	IPR023214	HAD-like_dom
# InterPro	IPR023299	ATPase_P-typ_cyto_domN
# InterPro	IPR027256	P-typ_ATPase_IB
# KEGG_Brite	ko01000	Enzymes
# KEGG_Disease	H00210	[Inherited metabolic disease; Nervous system disease; Liver disease] Hepatolenticular degeneration
# MIM	277900	phenotype
# MIM	606882	gene
# Organism	ATP7B_HUMAN	Homo sapiens (Human)
# Orphanet	905	Wilson disease
# PDB	2ARF	NMR; -; A=1032-1196
# PDB	2EW9	NMR; -; A=486-633
# PDB	2KOY	NMR; -; A=1036-1196
# PDB	2LQB	NMR; -; A=141-212
# PDB	2N7Y	NMR; -; A=56-127
# PDB	2ROP	NMR; -; A=238-439
# PIR	I78536	I78536
# PIR	I78537	I78537
# PIR	S78555	S78555
# PROSITE	PS00154	ATPASE_E1_E2
# PROSITE	PS01047	HMA_1; 6
# PROSITE	PS50846	HMA_2; 6
# PTM	ATP7B_HUMAN	Isoform 1 may be proteolytically cleaved at the N-terminus to produce the WND/140 kDa form. 
# Pfam	PF00122	E1-E2_ATPase
# Pfam	PF00403	HMA; 6
# Proteomes	UP000005640	Chromosome 13
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	ATP7B_HUMAN	Copper-transporting ATPase 2
# RecName	WND/140 kDa {ECO:0000303|PubMed	9600907}
# RefSeq	NP_000044	NM_000053.3. [P35670-1]
# RefSeq	NP_001230111	NM_001243182.1. [P35670-3]
# RefSeq	NP_001317507	NM_001330578.1
# RefSeq	NP_001317508	NM_001330579.1
# RefSeq	XP_005266487	XM_005266430.4. [P35670-1]
# SEQUENCE CAUTION	Sequence=AAA16173.1; Type=Frameshift; Positions=830; Evidence={ECO:0000305}; Sequence=AAA79211.1; Type=Frameshift; Positions=456; Evidence={ECO	0000305}; Sequence=AAA79212.1; Type=Frameshift; Positions=456; Evidence={ECO:0000305}; 
# SIMILARITY	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 6 HMA domains. {ECO:0000255|PROSITE- ProRule	PRU00280}. 
# SUBCELLULAR LOCATION	ATP7B_HUMAN	Golgi apparatus, trans-Golgi network membrane {ECO 0000269|PubMed 17919502, ECO 0000269|PubMed 22240481, ECO 0000269|PubMed 24706876}; Multi- pass membrane protein {ECO 0000255}. Late endosome {ECO 0000269|PubMed 11231950, ECO 0000269|PubMed 15681833}. Note=Predominantly found in the trans-Golgi network (TGN). Localized in the trans-Golgi network under low copper conditions, redistributes to cytoplasmic vesicles when cells are exposed to elevated copper levels, and then recycles back to the trans-Golgi network when copper is removed (PubMed 10942420). Not redistributed to the plasma membrane in response to elevated copper levels. {ECO 0000269|PubMed 10942420, ECO 0000269|PubMed 22240481, ECO 0000269|PubMed 24706876, ECO 0000269|PubMed 9307043}. 
# SUBCELLULAR LOCATION	ATP7B_HUMAN	Isoform 1  Golgi apparatus membrane {ECO 0000269|PubMed 9307043}; Multi-pass membrane protein {ECO 0000269|PubMed 9307043}. 
# SUBCELLULAR LOCATION	ATP7B_HUMAN	Isoform 2  Cytoplasm {ECO 0000269|PubMed 9307043}. 
# SUBCELLULAR LOCATION	ATP7B_HUMAN	WND/140 kDa  Mitochondrion {ECO 0000269|PubMed 9600907}. 
# SUBUNIT	ATP7B_HUMAN	Monomer. Interacts with COMMD1/MURR1 (PubMed 12968035, PubMed 17919502). Interacts with DCTN4, in a copper-dependent manner (PubMed 16554302). Interacts with ATOX1 (PubMed 18558714). Interacts (via C-terminus) with ZBTB16/PLZF (PubMed 16676348). {ECO 0000269|PubMed 12968035, ECO 0000269|PubMed 16554302, ECO 0000269|PubMed 16676348, ECO 0000269|PubMed 17919502, ECO 0000269|PubMed 18558714}. 
# SUPFAM	SSF55008	SSF55008; 6
# SUPFAM	SSF56784	SSF56784; 2
# TCDB	3.A.3.5	the p-type atpase (p-atpase) superfamily
# TIGRFAMs	TIGR00003	TIGR00003; 6
# TIGRFAMs	TIGR01494	ATPase_P-type; 2
# TIGRFAMs	TIGR01525	ATPase-IB_hvy
# TISSUE SPECIFICITY	ATP7B_HUMAN	Most abundant in liver and kidney and also found in brain. Isoform 2 is expressed in brain but not in liver. The cleaved form WND/140 kDa is found in liver cell lines and other tissues. 
# UCSC	uc001vfw	human. [P35670-1]
# WEB RESOURCE	ATP7B_HUMAN	Name=Wilson Disease Mutation Database; URL="http //www.medicalgenetics.med.ualberta.ca/wilson/index.php";
# eggNOG	COG2217	LUCA
# eggNOG	KOG0207	Eukaryota
BLAST	swissprot:ATP7B_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ATP7B_HUMAN
BioCyc	ZFISH:HS04640-MONOMER	http://biocyc.org/getid?id=ZFISH:HS04640-MONOMER
COG	COG2217	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2217
COXPRESdb	540	http://coxpresdb.jp/data/gene/540.shtml
CleanEx	HS_ATP7B	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP7B
DOI	10.1001/archneur.58.6.971	http://dx.doi.org/10.1001/archneur.58.6.971
DOI	10.1002/(SICI)1098-1004(1997)10:1<84::AID-HUMU14>3.3.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1997)10:1<84::AID-HUMU14>3.3.CO
DOI	10.1002/(SICI)1098-1004(1998)11:2<145::AID-HUMU7>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1998)11:2<145::AID-HUMU7>3.0.CO
DOI	10.1002/(SICI)1098-1004(1998)11:4<275::AID-HUMU4>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1998)11:4<275::AID-HUMU4>3.0.CO
DOI	10.1002/(SICI)1098-1004(1998)12:2<89::AID-HUMU3>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1998)12:2<89::AID-HUMU3>3.0.CO
DOI	10.1002/(SICI)1098-1004(1998)12:6<370::AID-HUMU2>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1998)12:6<370::AID-HUMU2>3.0.CO
DOI	10.1002/(SICI)1098-1004(1999)14:1<88::AID-HUMU15>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1999)14:1<88::AID-HUMU15>3.0.CO
DOI	10.1002/(SICI)1098-1004(199910)14:4<294::AID-HUMU4>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(199910)14:4<294::AID-HUMU4>3.0.CO
DOI	10.1002/(SICI)1098-1004(199910)14:4<304::AID-HUMU5>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(199910)14:4<304::AID-HUMU5>3.0.CO
DOI	10.1002/(SICI)1098-1004(200005)15:5<454::AID-HUMU7>3.3.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(200005)15:5<454::AID-HUMU7>3.3.CO
DOI	10.1002/1098-1004(200102)17:2<156::AID-HUMU18>3.0.CO	http://dx.doi.org/10.1002/1098-1004(200102)17:2<156::AID-HUMU18>3.0.CO
DOI	10.1002/humu.10121	http://dx.doi.org/10.1002/humu.10121
DOI	10.1002/humu.20674	http://dx.doi.org/10.1002/humu.20674
DOI	10.1002/humu.9227	http://dx.doi.org/10.1002/humu.9227
DOI	10.1002/humu.9358	http://dx.doi.org/10.1002/humu.9358
DOI	10.1002/jcb.20980	http://dx.doi.org/10.1002/jcb.20980
DOI	10.1006/bbrc.1993.2471	http://dx.doi.org/10.1006/bbrc.1993.2471
DOI	10.1006/bbrc.1999.0732	http://dx.doi.org/10.1006/bbrc.1999.0732
DOI	10.1006/geno.1996.0564	http://dx.doi.org/10.1006/geno.1996.0564
DOI	10.1006/mgme.2000.3143	http://dx.doi.org/10.1006/mgme.2000.3143
DOI	10.1007/s00109-005-0036-y	http://dx.doi.org/10.1007/s00109-005-0036-y
DOI	10.1007/s00431-001-0865-9	http://dx.doi.org/10.1007/s00431-001-0865-9
DOI	10.1007/s004390050275	http://dx.doi.org/10.1007/s004390050275
DOI	10.1007/s100380050017	http://dx.doi.org/10.1007/s100380050017
DOI	10.1007/s100380070015	http://dx.doi.org/10.1007/s100380070015
DOI	10.1007/s100380200082	http://dx.doi.org/10.1007/s100380200082
DOI	10.1007/s10571-007-9192-7	http://dx.doi.org/10.1007/s10571-007-9192-7
DOI	10.1007/s12519-012-0388-7	http://dx.doi.org/10.1007/s12519-012-0388-7
DOI	10.1016/S0002-9440(10)62272-9	http://dx.doi.org/10.1016/S0002-9440(10)62272-9
DOI	10.1016/S0168-8278(01)00219-7	http://dx.doi.org/10.1016/S0168-8278(01)00219-7
DOI	10.1016/j.ejmg.2013.01.003	http://dx.doi.org/10.1016/j.ejmg.2013.01.003
DOI	10.1016/j.gene.2015.05.031	http://dx.doi.org/10.1016/j.gene.2015.05.031
DOI	10.1016/j.jns.2011.09.007	http://dx.doi.org/10.1016/j.jns.2011.09.007
DOI	10.1016/j.mcp.2012.03.007	http://dx.doi.org/10.1016/j.mcp.2012.03.007
DOI	10.1016/j.ymgme.2005.05.004	http://dx.doi.org/10.1016/j.ymgme.2005.05.004
DOI	10.1021/bi8004736	http://dx.doi.org/10.1021/bi8004736
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/jhg.2012.134	http://dx.doi.org/10.1038/jhg.2012.134
DOI	10.1038/nature02379	http://dx.doi.org/10.1038/nature02379
DOI	10.1038/ng0295-210	http://dx.doi.org/10.1038/ng0295-210
DOI	10.1038/ng1293-327	http://dx.doi.org/10.1038/ng1293-327
DOI	10.1038/ng1293-344	http://dx.doi.org/10.1038/ng1293-344
DOI	10.1042/bj3260897	http://dx.doi.org/10.1042/bj3260897
DOI	10.1046/j.1399-0004.2003.00179.x	http://dx.doi.org/10.1046/j.1399-0004.2003.00179.x
DOI	10.1046/j.1442-200X.1999.01092.x	http://dx.doi.org/10.1046/j.1442-200X.1999.01092.x
DOI	10.1046/j.1529-8817.2005.00171.x	http://dx.doi.org/10.1046/j.1529-8817.2005.00171.x
DOI	10.1053/gast.2001.22543	http://dx.doi.org/10.1053/gast.2001.22543
DOI	10.1053/j.gastro.2007.07.020	http://dx.doi.org/10.1053/j.gastro.2007.07.020
DOI	10.1053/j.gastro.2011.12.048	http://dx.doi.org/10.1053/j.gastro.2011.12.048
DOI	10.1053/jhep.2000.20152	http://dx.doi.org/10.1053/jhep.2000.20152
DOI	10.1073/pnas.1014959108	http://dx.doi.org/10.1073/pnas.1014959108
DOI	10.1073/pnas.1314161111	http://dx.doi.org/10.1073/pnas.1314161111
DOI	10.1073/pnas.95.11.6004	http://dx.doi.org/10.1073/pnas.95.11.6004
DOI	10.1074/jbc.C300391200	http://dx.doi.org/10.1074/jbc.C300391200
DOI	10.1074/jbc.M109.074633	http://dx.doi.org/10.1074/jbc.M109.074633
DOI	10.1074/jbc.M110.198101	http://dx.doi.org/10.1074/jbc.M110.198101
DOI	10.1074/jbc.M300034200	http://dx.doi.org/10.1074/jbc.M300034200
DOI	10.1074/jbc.M512745200	http://dx.doi.org/10.1074/jbc.M512745200
DOI	10.1086/302163	http://dx.doi.org/10.1086/302163
DOI	10.1086/514864	http://dx.doi.org/10.1086/514864
DOI	10.1089/109065700750065162	http://dx.doi.org/10.1089/109065700750065162
DOI	10.1089/gte.2007.0015	http://dx.doi.org/10.1089/gte.2007.0015
DOI	10.1089/gte.2007.0072	http://dx.doi.org/10.1089/gte.2007.0072
DOI	10.1093/brain/awt035	http://dx.doi.org/10.1093/brain/awt035
DOI	10.1093/hmg/3.9.1647	http://dx.doi.org/10.1093/hmg/3.9.1647
DOI	10.1093/hmg/9.13.1927	http://dx.doi.org/10.1093/hmg/9.13.1927
DOI	10.1097/00125817-200211001-00009	http://dx.doi.org/10.1097/00125817-200211001-00009
DOI	10.1111/1523-1747.ep12285622	http://dx.doi.org/10.1111/1523-1747.ep12285622
DOI	10.1111/j.1399-0004.2005.00439.x	http://dx.doi.org/10.1111/j.1399-0004.2005.00439.x
DOI	10.1111/j.1399-0004.2005.00440.x	http://dx.doi.org/10.1111/j.1399-0004.2005.00440.x
DOI	10.1111/j.1399-0004.2005.00516.x	http://dx.doi.org/10.1111/j.1399-0004.2005.00516.x
DOI	10.1111/j.1399-0004.2005.00528.x	http://dx.doi.org/10.1111/j.1399-0004.2005.00528.x
DOI	10.1111/j.1399-0004.2007.00853.x	http://dx.doi.org/10.1111/j.1399-0004.2007.00853.x
DOI	10.1111/j.1478-3231.2011.02503.x	http://dx.doi.org/10.1111/j.1478-3231.2011.02503.x
DOI	10.1136/jmg.33.6.521	http://dx.doi.org/10.1136/jmg.33.6.521
DOI	10.1152/ajpgi.00038.2011	http://dx.doi.org/10.1152/ajpgi.00038.2011
DOI	10.1159/000075092	http://dx.doi.org/10.1159/000075092
DOI	10.1186/1471-2431-11-56	http://dx.doi.org/10.1186/1471-2431-11-56
DOI	10.1212/01.WNL.0000144192.30426.38	http://dx.doi.org/10.1212/01.WNL.0000144192.30426.38
DOI	10.3748/wjg.v10.i4.590	http://dx.doi.org/10.3748/wjg.v10.i4.590
DOI	10.4254/wjh.v5.i11.649	http://dx.doi.org/10.4254/wjh.v5.i11.649
DrugBank	DB00515	http://www.drugbank.ca/drugs/DB00515
DrugBank	DB00526	http://www.drugbank.ca/drugs/DB00526
DrugBank	DB00958	http://www.drugbank.ca/drugs/DB00958
EC_number	EC:3.6.3.54 {ECO:0000269|PubMed:22240481}	http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.54 {ECO:0000269|PubMed:22240481}
EMBL	AB209461	http://www.ebi.ac.uk/ena/data/view/AB209461
EMBL	AF034838	http://www.ebi.ac.uk/ena/data/view/AF034838
EMBL	AL138821	http://www.ebi.ac.uk/ena/data/view/AL138821
EMBL	AL138821	http://www.ebi.ac.uk/ena/data/view/AL138821
EMBL	AL138821	http://www.ebi.ac.uk/ena/data/view/AL138821
EMBL	AL139082	http://www.ebi.ac.uk/ena/data/view/AL139082
EMBL	AL139082	http://www.ebi.ac.uk/ena/data/view/AL139082
EMBL	AL139082	http://www.ebi.ac.uk/ena/data/view/AL139082
EMBL	AL162377	http://www.ebi.ac.uk/ena/data/view/AL162377
EMBL	AL162377	http://www.ebi.ac.uk/ena/data/view/AL162377
EMBL	AL162377	http://www.ebi.ac.uk/ena/data/view/AL162377
EMBL	DQ015922	http://www.ebi.ac.uk/ena/data/view/DQ015922
EMBL	L25442	http://www.ebi.ac.uk/ena/data/view/L25442
EMBL	L25591	http://www.ebi.ac.uk/ena/data/view/L25591
EMBL	L25591	http://www.ebi.ac.uk/ena/data/view/L25591
EMBL	S77446	http://www.ebi.ac.uk/ena/data/view/S77446
EMBL	S77447	http://www.ebi.ac.uk/ena/data/view/S77447
EMBL	S77450	http://www.ebi.ac.uk/ena/data/view/S77450
EMBL	U03464	http://www.ebi.ac.uk/ena/data/view/U03464
EMBL	U11700	http://www.ebi.ac.uk/ena/data/view/U11700
ENZYME	3.6.3.54 {ECO:0000269|PubMed:22240481}	http://enzyme.expasy.org/EC/3.6.3.54 {ECO:0000269|PubMed:22240481}
Ensembl	ENST00000242839	http://www.ensembl.org/id/ENST00000242839
Ensembl	ENST00000344297	http://www.ensembl.org/id/ENST00000344297
Ensembl	ENST00000400366	http://www.ensembl.org/id/ENST00000400366
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005770	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005770
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0032588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032588
GO_function	GO:0004008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004008
GO_function	GO:0005507	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005507
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0043682	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043682
GO_process	GO:0006825	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006825
GO_process	GO:0006878	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006878
GO_process	GO:0006882	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006882
GO_process	GO:0007595	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007595
GO_process	GO:0015677	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015677
GO_process	GO:0015680	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015680
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0046688	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046688
GO_process	GO:0051208	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051208
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.70.150.10	http://www.cathdb.info/version/latest/superfamily/2.70.150.10
Gene3D	3.40.1110.10	http://www.cathdb.info/version/latest/superfamily/3.40.1110.10
Gene3D	3.40.50.1000	http://www.cathdb.info/version/latest/superfamily/3.40.50.1000
GeneCards	ATP7B	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP7B
GeneID	540	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=540
GeneTree	ENSGT00530000063773	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063773
HGNC	HGNC:870	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:870
HOGENOM	HOG000250397	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000250397&db=HOGENOM6
HOVERGEN	HBG050616	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050616&db=HOVERGEN
HPA	HPA013187	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA013187
InParanoid	P35670	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P35670
IntEnz	3.6.3.54 {ECO:0000269|PubMed:22240481}	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.54 {ECO:0000269|PubMed:22240481}
InterPro	IPR001757	http://www.ebi.ac.uk/interpro/entry/IPR001757
InterPro	IPR006121	http://www.ebi.ac.uk/interpro/entry/IPR006121
InterPro	IPR006122	http://www.ebi.ac.uk/interpro/entry/IPR006122
InterPro	IPR008250	http://www.ebi.ac.uk/interpro/entry/IPR008250
InterPro	IPR017969	http://www.ebi.ac.uk/interpro/entry/IPR017969
InterPro	IPR018303	http://www.ebi.ac.uk/interpro/entry/IPR018303
InterPro	IPR023214	http://www.ebi.ac.uk/interpro/entry/IPR023214
InterPro	IPR023299	http://www.ebi.ac.uk/interpro/entry/IPR023299
InterPro	IPR027256	http://www.ebi.ac.uk/interpro/entry/IPR027256
Jabion	540	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=540
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Disease	H00210	http://www.genome.jp/dbget-bin/www_bget?H00210
KEGG_Gene	hsa:540	http://www.genome.jp/dbget-bin/www_bget?hsa:540
KEGG_Orthology	KO:K01533	http://www.genome.jp/dbget-bin/www_bget?KO:K01533
MIM	277900	http://www.ncbi.nlm.nih.gov/omim/277900
MIM	606882	http://www.ncbi.nlm.nih.gov/omim/606882
MINT	MINT-105941	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-105941
OMA	AVAPQKC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AVAPQKC
Orphanet	905	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=905
OrthoDB	EOG091G022E	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G022E
PDB	2ARF	http://www.ebi.ac.uk/pdbe-srv/view/entry/2ARF
PDB	2EW9	http://www.ebi.ac.uk/pdbe-srv/view/entry/2EW9
PDB	2KOY	http://www.ebi.ac.uk/pdbe-srv/view/entry/2KOY
PDB	2LQB	http://www.ebi.ac.uk/pdbe-srv/view/entry/2LQB
PDB	2N7Y	http://www.ebi.ac.uk/pdbe-srv/view/entry/2N7Y
PDB	2ROP	http://www.ebi.ac.uk/pdbe-srv/view/entry/2ROP
PDBsum	2ARF	http://www.ebi.ac.uk/pdbsum/2ARF
PDBsum	2EW9	http://www.ebi.ac.uk/pdbsum/2EW9
PDBsum	2KOY	http://www.ebi.ac.uk/pdbsum/2KOY
PDBsum	2LQB	http://www.ebi.ac.uk/pdbsum/2LQB
PDBsum	2N7Y	http://www.ebi.ac.uk/pdbsum/2N7Y
PDBsum	2ROP	http://www.ebi.ac.uk/pdbsum/2ROP
PROSITE	PS00154	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00154
PROSITE	PS01047	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01047
PROSITE	PS50846	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50846
PSORT	swissprot:ATP7B_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ATP7B_HUMAN
PSORT-B	swissprot:ATP7B_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ATP7B_HUMAN
PSORT2	swissprot:ATP7B_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ATP7B_HUMAN
Pfam	PF00122	http://pfam.xfam.org/family/PF00122
Pfam	PF00403	http://pfam.xfam.org/family/PF00403
PharmGKB	PA73	http://www.pharmgkb.org/do/serve?objId=PA73&objCls=Gene
Phobius	swissprot:ATP7B_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ATP7B_HUMAN
PhylomeDB	P35670	http://phylomedb.org/?seqid=P35670
ProteinModelPortal	P35670	http://www.proteinmodelportal.org/query/uniprot/P35670
PubMed	10051024	http://www.ncbi.nlm.nih.gov/pubmed/10051024
PubMed	10194254	http://www.ncbi.nlm.nih.gov/pubmed/10194254
PubMed	10334941	http://www.ncbi.nlm.nih.gov/pubmed/10334941
PubMed	10447265	http://www.ncbi.nlm.nih.gov/pubmed/10447265
PubMed	10453196	http://www.ncbi.nlm.nih.gov/pubmed/10453196
PubMed	10502776	http://www.ncbi.nlm.nih.gov/pubmed/10502776
PubMed	10502777	http://www.ncbi.nlm.nih.gov/pubmed/10502777
PubMed	10544227	http://www.ncbi.nlm.nih.gov/pubmed/10544227
PubMed	10721669	http://www.ncbi.nlm.nih.gov/pubmed/10721669
PubMed	10790207	http://www.ncbi.nlm.nih.gov/pubmed/10790207
PubMed	10942420	http://www.ncbi.nlm.nih.gov/pubmed/10942420
PubMed	11043508	http://www.ncbi.nlm.nih.gov/pubmed/11043508
PubMed	11093740	http://www.ncbi.nlm.nih.gov/pubmed/11093740
PubMed	11180609	http://www.ncbi.nlm.nih.gov/pubmed/11180609
PubMed	11216666	http://www.ncbi.nlm.nih.gov/pubmed/11216666
PubMed	11231950	http://www.ncbi.nlm.nih.gov/pubmed/11231950
PubMed	11243728	http://www.ncbi.nlm.nih.gov/pubmed/11243728
PubMed	11405812	http://www.ncbi.nlm.nih.gov/pubmed/11405812
PubMed	11690702	http://www.ncbi.nlm.nih.gov/pubmed/11690702
PubMed	11954751	http://www.ncbi.nlm.nih.gov/pubmed/11954751
PubMed	12325021	http://www.ncbi.nlm.nih.gov/pubmed/12325021
PubMed	12376745	http://www.ncbi.nlm.nih.gov/pubmed/12376745
PubMed	12544487	http://www.ncbi.nlm.nih.gov/pubmed/12544487
PubMed	12551905	http://www.ncbi.nlm.nih.gov/pubmed/12551905
PubMed	12968035	http://www.ncbi.nlm.nih.gov/pubmed/12968035
PubMed	14639035	http://www.ncbi.nlm.nih.gov/pubmed/14639035
PubMed	14966923	http://www.ncbi.nlm.nih.gov/pubmed/14966923
PubMed	14986826	http://www.ncbi.nlm.nih.gov/pubmed/14986826
PubMed	15024742	http://www.ncbi.nlm.nih.gov/pubmed/15024742
PubMed	15057823	http://www.ncbi.nlm.nih.gov/pubmed/15057823
PubMed	15557537	http://www.ncbi.nlm.nih.gov/pubmed/15557537
PubMed	15681833	http://www.ncbi.nlm.nih.gov/pubmed/15681833
PubMed	15811015	http://www.ncbi.nlm.nih.gov/pubmed/15811015
PubMed	15845031	http://www.ncbi.nlm.nih.gov/pubmed/15845031
PubMed	15952988	http://www.ncbi.nlm.nih.gov/pubmed/15952988
PubMed	15967699	http://www.ncbi.nlm.nih.gov/pubmed/15967699
PubMed	16088907	http://www.ncbi.nlm.nih.gov/pubmed/16088907
PubMed	16207219	http://www.ncbi.nlm.nih.gov/pubmed/16207219
PubMed	16283883	http://www.ncbi.nlm.nih.gov/pubmed/16283883
PubMed	16554302	http://www.ncbi.nlm.nih.gov/pubmed/16554302
PubMed	16649058	http://www.ncbi.nlm.nih.gov/pubmed/16649058
PubMed	16676348	http://www.ncbi.nlm.nih.gov/pubmed/16676348
PubMed	17718866	http://www.ncbi.nlm.nih.gov/pubmed/17718866
PubMed	17823867	http://www.ncbi.nlm.nih.gov/pubmed/17823867
PubMed	17919502	http://www.ncbi.nlm.nih.gov/pubmed/17919502
PubMed	17949296	http://www.ncbi.nlm.nih.gov/pubmed/17949296
PubMed	18203200	http://www.ncbi.nlm.nih.gov/pubmed/18203200
PubMed	18373411	http://www.ncbi.nlm.nih.gov/pubmed/18373411
PubMed	18558714	http://www.ncbi.nlm.nih.gov/pubmed/18558714
PubMed	20032459	http://www.ncbi.nlm.nih.gov/pubmed/20032459
PubMed	21398519	http://www.ncbi.nlm.nih.gov/pubmed/21398519
PubMed	21406592	http://www.ncbi.nlm.nih.gov/pubmed/21406592
PubMed	21454443	http://www.ncbi.nlm.nih.gov/pubmed/21454443
PubMed	21645214	http://www.ncbi.nlm.nih.gov/pubmed/21645214
PubMed	21682854	http://www.ncbi.nlm.nih.gov/pubmed/21682854
PubMed	22075048	http://www.ncbi.nlm.nih.gov/pubmed/22075048
PubMed	22240481	http://www.ncbi.nlm.nih.gov/pubmed/22240481
PubMed	22484412	http://www.ncbi.nlm.nih.gov/pubmed/22484412
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	23235335	http://www.ncbi.nlm.nih.gov/pubmed/23235335
PubMed	23275100	http://www.ncbi.nlm.nih.gov/pubmed/23275100
PubMed	23333878	http://www.ncbi.nlm.nih.gov/pubmed/23333878
PubMed	23518715	http://www.ncbi.nlm.nih.gov/pubmed/23518715
PubMed	24303094	http://www.ncbi.nlm.nih.gov/pubmed/24303094
PubMed	24706876	http://www.ncbi.nlm.nih.gov/pubmed/24706876
PubMed	25982861	http://www.ncbi.nlm.nih.gov/pubmed/25982861
PubMed	7626145	http://www.ncbi.nlm.nih.gov/pubmed/7626145
PubMed	7833924	http://www.ncbi.nlm.nih.gov/pubmed/7833924
PubMed	8250934	http://www.ncbi.nlm.nih.gov/pubmed/8250934
PubMed	8298639	http://www.ncbi.nlm.nih.gov/pubmed/8298639
PubMed	8298641	http://www.ncbi.nlm.nih.gov/pubmed/8298641
PubMed	8533760	http://www.ncbi.nlm.nih.gov/pubmed/8533760
PubMed	8782057	http://www.ncbi.nlm.nih.gov/pubmed/8782057
PubMed	8931691	http://www.ncbi.nlm.nih.gov/pubmed/8931691
PubMed	8938442	http://www.ncbi.nlm.nih.gov/pubmed/8938442
PubMed	8980283	http://www.ncbi.nlm.nih.gov/pubmed/8980283
PubMed	9222767	http://www.ncbi.nlm.nih.gov/pubmed/9222767
PubMed	9307043	http://www.ncbi.nlm.nih.gov/pubmed/9307043
PubMed	9311736	http://www.ncbi.nlm.nih.gov/pubmed/9311736
PubMed	9452121	http://www.ncbi.nlm.nih.gov/pubmed/9452121
PubMed	9482578	http://www.ncbi.nlm.nih.gov/pubmed/9482578
PubMed	9554743	http://www.ncbi.nlm.nih.gov/pubmed/9554743
PubMed	9600907	http://www.ncbi.nlm.nih.gov/pubmed/9600907
PubMed	9671269	http://www.ncbi.nlm.nih.gov/pubmed/9671269
PubMed	9772425	http://www.ncbi.nlm.nih.gov/pubmed/9772425
PubMed	9829905	http://www.ncbi.nlm.nih.gov/pubmed/9829905
PubMed	9837819	http://www.ncbi.nlm.nih.gov/pubmed/9837819
PubMed	9887381	http://www.ncbi.nlm.nih.gov/pubmed/9887381
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_000044	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000044
RefSeq	NP_001230111	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001230111
RefSeq	NP_001317507	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001317507
RefSeq	NP_001317508	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001317508
RefSeq	XP_005266487	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005266487
SMR	P35670	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P35670
STRING	9606.ENSP00000242839	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000242839&targetmode=cogs
STRING	COG2217	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2217&targetmode=cogs
SUPFAM	SSF55008	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55008
SUPFAM	SSF56784	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784
TCDB	3.A.3.5	http://www.tcdb.org/search/result.php?tc=3.A.3.5
TIGRFAMs	TIGR00003	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00003
TIGRFAMs	TIGR01494	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01494
TIGRFAMs	TIGR01525	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01525
UCSC	uc001vfw	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001vfw&org=rat
UniGene	Hs.492280	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.492280
UniProtKB	ATP7B_HUMAN	http://www.uniprot.org/uniprot/ATP7B_HUMAN
UniProtKB-AC	P35670	http://www.uniprot.org/uniprot/P35670
charge	swissprot:ATP7B_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ATP7B_HUMAN
eggNOG	COG2217	http://eggnogapi.embl.de/nog_data/html/tree/COG2217
eggNOG	KOG0207	http://eggnogapi.embl.de/nog_data/html/tree/KOG0207
epestfind	swissprot:ATP7B_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ATP7B_HUMAN
garnier	swissprot:ATP7B_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ATP7B_HUMAN
helixturnhelix	swissprot:ATP7B_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATP7B_HUMAN
hmoment	swissprot:ATP7B_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ATP7B_HUMAN
iep	swissprot:ATP7B_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ATP7B_HUMAN
inforesidue	swissprot:ATP7B_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ATP7B_HUMAN
neXtProt	NX_P35670	http://www.nextprot.org/db/entry/NX_P35670
octanol	swissprot:ATP7B_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ATP7B_HUMAN
pepcoil	swissprot:ATP7B_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ATP7B_HUMAN
pepdigest	swissprot:ATP7B_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ATP7B_HUMAN
pepinfo	swissprot:ATP7B_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ATP7B_HUMAN
pepnet	swissprot:ATP7B_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ATP7B_HUMAN
pepstats	swissprot:ATP7B_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ATP7B_HUMAN
pepwheel	swissprot:ATP7B_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ATP7B_HUMAN
pepwindow	swissprot:ATP7B_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ATP7B_HUMAN
sigcleave	swissprot:ATP7B_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ATP7B_HUMAN
## Database	ID	URL or Descriptions
# AltName	NTCP4_HUMAN	Na(+)/bile acid cotransporter 4
# AltName	NTCP4_HUMAN	Solute carrier family 10 member 4
# Ensembl	ENST00000273861	ENSP00000273861; ENSG00000145248
# FUNCTION	NTCP4_HUMAN	Transporter for bile acids. {ECO 0000269|PubMed 23589386}. 
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	NTCP4_HUMAN	GO 0008508 bile acid sodium symporter activity; IBA GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# Genevisible	Q96EP9	HS
# HGNC	HGNC:22980	SLC10A4
# InterPro	IPR002657:BilAc	Na_symport/Acr3
# KEGG_Brite	ko02001	Solute carrier family
# Organism	NTCP4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10361	PTHR10361
# PTM	NTCP4_HUMAN	Activated following N-terminal proteolytic cleavage by thrombin and/or proteases. {ECO 0000269|PubMed 23589386}. 
# Pfam	PF01758	SBF
# Proteomes	UP000005640	Chromosome 4
# RecName	NTCP4_HUMAN	Sodium/bile acid cotransporter 4
# RefSeq	NP_689892	NM_152679.3
# SIMILARITY	Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	NTCP4_HUMAN	Cell membrane {ECO 0000269|PubMed 23589386}; Multi-pass membrane protein {ECO 0000269|PubMed 23589386}. 
# TCDB	2.A.28.1:the bile acid	na(+) symporter (bass) family
# TISSUE SPECIFICITY	Highly expressed in brain and small intestine, and moderately expressed in colon, heart, prostate, and testis. Very low levels were detected in kidney, liver, ovary, placenta, spleen, and thymus. {ECO:0000269|PubMed	18355966}. 
# UCSC	uc003gyc	human
# eggNOG	COG0385	LUCA
# eggNOG	KOG2718	Eukaryota
BLAST	swissprot:NTCP4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NTCP4_HUMAN
BioCyc	ZFISH:ENSG00000145248-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000145248-MONOMER
COXPRESdb	201780	http://coxpresdb.jp/data/gene/201780.shtml
CleanEx	HS_SLC10A4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC10A4
DOI	10.1016/j.neuroscience.2008.01.049	http://dx.doi.org/10.1016/j.neuroscience.2008.01.049
DOI	10.1093/jb/mvt031	http://dx.doi.org/10.1093/jb/mvt031
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AY704414	http://www.ebi.ac.uk/ena/data/view/AY704414
EMBL	BC012048	http://www.ebi.ac.uk/ena/data/view/BC012048
EMBL	BC019066	http://www.ebi.ac.uk/ena/data/view/BC019066
Ensembl	ENST00000273861	http://www.ensembl.org/id/ENST00000273861
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0008508	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008508
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GeneCards	SLC10A4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC10A4
GeneID	201780	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=201780
GeneTree	ENSGT00550000074505	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074505
HGNC	HGNC:22980	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:22980
HOGENOM	HOG000234524	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234524&db=HOGENOM6
HOVERGEN	HBG096155	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG096155&db=HOVERGEN
HPA	HPA028835	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA028835
InParanoid	Q96EP9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96EP9
InterPro	IPR002657	http://www.ebi.ac.uk/interpro/entry/IPR002657
Jabion	201780	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=201780
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:201780	http://www.genome.jp/dbget-bin/www_bget?hsa:201780
KEGG_Orthology	KO:K14344	http://www.genome.jp/dbget-bin/www_bget?KO:K14344
OMA	PHALPFW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PHALPFW
OrthoDB	EOG091G0GT5	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0GT5
PANTHER	PTHR10361	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10361
PSORT	swissprot:NTCP4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NTCP4_HUMAN
PSORT-B	swissprot:NTCP4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NTCP4_HUMAN
PSORT2	swissprot:NTCP4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NTCP4_HUMAN
Pfam	PF01758	http://pfam.xfam.org/family/PF01758
PharmGKB	PA134941471	http://www.pharmgkb.org/do/serve?objId=PA134941471&objCls=Gene
Phobius	swissprot:NTCP4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NTCP4_HUMAN
PhylomeDB	Q96EP9	http://phylomedb.org/?seqid=Q96EP9
ProteinModelPortal	Q96EP9	http://www.proteinmodelportal.org/query/uniprot/Q96EP9
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18355966	http://www.ncbi.nlm.nih.gov/pubmed/18355966
PubMed	23589386	http://www.ncbi.nlm.nih.gov/pubmed/23589386
RefSeq	NP_689892	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_689892
STRING	9606.ENSP00000273861	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000273861&targetmode=cogs
TCDB	2.A.28.1	http://www.tcdb.org/search/result.php?tc=2.A.28.1
UCSC	uc003gyc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003gyc&org=rat
UniGene	Hs.132591	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.132591
UniProtKB	NTCP4_HUMAN	http://www.uniprot.org/uniprot/NTCP4_HUMAN
UniProtKB-AC	Q96EP9	http://www.uniprot.org/uniprot/Q96EP9
charge	swissprot:NTCP4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NTCP4_HUMAN
eggNOG	COG0385	http://eggnogapi.embl.de/nog_data/html/tree/COG0385
eggNOG	KOG2718	http://eggnogapi.embl.de/nog_data/html/tree/KOG2718
epestfind	swissprot:NTCP4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NTCP4_HUMAN
garnier	swissprot:NTCP4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NTCP4_HUMAN
helixturnhelix	swissprot:NTCP4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NTCP4_HUMAN
hmoment	swissprot:NTCP4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NTCP4_HUMAN
iep	swissprot:NTCP4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NTCP4_HUMAN
inforesidue	swissprot:NTCP4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NTCP4_HUMAN
neXtProt	NX_Q96EP9	http://www.nextprot.org/db/entry/NX_Q96EP9
octanol	swissprot:NTCP4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NTCP4_HUMAN
pepcoil	swissprot:NTCP4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NTCP4_HUMAN
pepdigest	swissprot:NTCP4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NTCP4_HUMAN
pepinfo	swissprot:NTCP4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NTCP4_HUMAN
pepnet	swissprot:NTCP4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NTCP4_HUMAN
pepstats	swissprot:NTCP4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NTCP4_HUMAN
pepwheel	swissprot:NTCP4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NTCP4_HUMAN
pepwindow	swissprot:NTCP4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NTCP4_HUMAN
sigcleave	swissprot:NTCP4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NTCP4_HUMAN
## Database	ID	URL or Descriptions
# CAUTION	In contrast to other members of the family, this protein is much shorter and lacks the VWFA domain. Defined as a pseudogene by HGNC. PubMed:10095065 reports that it is expressed and glycosylated in mammalian cells. {ECO	0000305}.
# GO_component	GO:0005615	extracellular space; TAS:ProtInc.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_function	GO:0004222	metalloendopeptidase activity; TAS:Reactome.
# GO_function	GO:0005215	transporter activity; TAS:ProtInc.
# GO_function	GO:0005244	voltage-gated ion channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0005254	chloride channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0005262	calcium channel activity; IEA:UniProtKB-KW.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005615	extracellular space
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008233	peptidase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# HGNC	HGNC:2017	CLCA3P
# InterPro	IPR013642	CLCA
# MIM	604337	gene
# Organism	CLCA3_HUMAN	Homo sapiens (Human)
# PTM	CLCA3_HUMAN	N-glycosylated. {ECO 0000269|PubMed 10095065}. 
# Pfam	PF08434	CLCA
# Proteomes	UP000005640	Unplaced
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	CLCA3_HUMAN	Calcium-activated chloride channel regulator family member 3
# SIMILARITY	Belongs to the CLCR family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	CLCA3_HUMAN	Secreted {ECO 0000269|PubMed 10095065}. 
# TCDB	1.A.13.1	the epithelial chloride channel (e-clc) family
# TISSUE SPECIFICITY	Expressed in the lung, trachea, spleen, thymus and mammary gland. {ECO:0000269|PubMed	10095065}. 
BLAST	swissprot:CLCA3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CLCA3_HUMAN
BioCyc	ZFISH:ENSG00000153923-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000153923-MONOMER
DOI	10.1016/S0167-4781(99)00008-1	http://dx.doi.org/10.1016/S0167-4781(99)00008-1
EMBL	AF043976	http://www.ebi.ac.uk/ena/data/view/AF043976
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005615
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_function	GO:0004222	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004222
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0005244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005244
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005615
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008233	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	CLCA3P	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CLCA3P
H-InvDB	HIX0028523	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0028523
HGNC	HGNC:2017	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2017
HOVERGEN	HBG052848	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052848&db=HOVERGEN
InParanoid	Q9Y6N3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y6N3
InterPro	IPR013642	http://www.ebi.ac.uk/interpro/entry/IPR013642
MIM	604337	http://www.ncbi.nlm.nih.gov/omim/604337
PSORT	swissprot:CLCA3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CLCA3_HUMAN
PSORT-B	swissprot:CLCA3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CLCA3_HUMAN
PSORT2	swissprot:CLCA3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CLCA3_HUMAN
Pfam	PF08434	http://pfam.xfam.org/family/PF08434
Phobius	swissprot:CLCA3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CLCA3_HUMAN
PhylomeDB	Q9Y6N3	http://phylomedb.org/?seqid=Q9Y6N3
ProteinModelPortal	Q9Y6N3	http://www.proteinmodelportal.org/query/uniprot/Q9Y6N3
PubMed	10095065	http://www.ncbi.nlm.nih.gov/pubmed/10095065
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
TCDB	1.A.13.1	http://www.tcdb.org/search/result.php?tc=1.A.13.1
UniGene	Hs.673847	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.673847
UniProtKB	CLCA3_HUMAN	http://www.uniprot.org/uniprot/CLCA3_HUMAN
UniProtKB-AC	Q9Y6N3	http://www.uniprot.org/uniprot/Q9Y6N3
charge	swissprot:CLCA3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CLCA3_HUMAN
epestfind	swissprot:CLCA3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CLCA3_HUMAN
garnier	swissprot:CLCA3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CLCA3_HUMAN
helixturnhelix	swissprot:CLCA3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLCA3_HUMAN
hmoment	swissprot:CLCA3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CLCA3_HUMAN
iep	swissprot:CLCA3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CLCA3_HUMAN
inforesidue	swissprot:CLCA3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CLCA3_HUMAN
neXtProt	NX_Q9Y6N3	http://www.nextprot.org/db/entry/NX_Q9Y6N3
octanol	swissprot:CLCA3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CLCA3_HUMAN
pepcoil	swissprot:CLCA3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CLCA3_HUMAN
pepdigest	swissprot:CLCA3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CLCA3_HUMAN
pepinfo	swissprot:CLCA3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CLCA3_HUMAN
pepnet	swissprot:CLCA3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CLCA3_HUMAN
pepstats	swissprot:CLCA3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CLCA3_HUMAN
pepwheel	swissprot:CLCA3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CLCA3_HUMAN
pepwindow	swissprot:CLCA3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CLCA3_HUMAN
sigcleave	swissprot:CLCA3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CLCA3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AQP1_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=P29972-1; Sequence=Displayed; Name=2; IsoId=P29972-2; Sequence=VSP_046109, VSP_046110; Note=No experimental confirmation available.; Name=3; IsoId=P29972-3; Sequence=VSP_046679; Note=Gene prediction based on EST data.; Name=4; IsoId=P29972-4; Sequence=VSP_046680, VSP_046681; Note=Gene prediction based on EST data.; 
# AltName	AQP1_HUMAN	Aquaporin-CHIP
# AltName	AQP1_HUMAN	Urine water channel
# AltName	AQP1_HUMAN	Water channel protein for red blood cells and kidney proximal tubule
# BioGrid	106854	42
# CCDS	CCDS5431	-. [P29972-1]
# CDD	cd00333	MIP
# ChiTaRS	AQP1	human
# DOMAIN	AQP1_HUMAN	Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). 
# DrugBank	DB00819	Acetazolamide
# Ensembl	ENST00000311813	ENSP00000311165; ENSG00000240583. [P29972-1]
# Ensembl	ENST00000409611	ENSP00000387178; ENSG00000240583. [P29972-3]
# Ensembl	ENST00000409899	ENSP00000386712; ENSG00000240583. [P29972-4]
# Ensembl	ENST00000441328	ENSP00000405698; ENSG00000240583. [P29972-2]
# ExpressionAtlas	P29972	baseline and differential
# FUNCTION	AQP1_HUMAN	Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. {ECO 0000269|PubMed 1373524}. 
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0005903	brush border; IDA:UniProtKB.
# GO_component	GO:0009925	basal plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016323	basolateral plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_component	GO:0020003	symbiont-containing vacuole; ISS:UniProtKB.
# GO_component	GO:0031526	brush border membrane; IDA:UniProtKB.
# GO_component	GO:0031965	nuclear membrane; IDA:UniProtKB.
# GO_component	GO:0042383	sarcolemma; IDA:UniProtKB.
# GO_component	GO:0045177	apical part of cell; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005223	intracellular cGMP activated cation channel activity; IDA:UniProtKB.
# GO_function	GO:0005267	potassium channel activity; IMP:UniProtKB.
# GO_function	GO:0005372	water transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0008519	ammonium transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015079	potassium ion transmembrane transporter activity; ISS:UniProtKB.
# GO_function	GO:0015168	glycerol transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015250	water channel activity; IDA:UniProtKB.
# GO_function	GO:0015254	glycerol channel activity; IBA:GO_Central.
# GO_function	GO:0022857	transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0030184	nitric oxide transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0035379	carbon dioxide transmembrane transporter activity; IDA:UniProtKB.
# GO_process	GO:0003091	renal water homeostasis; TAS:Reactome.
# GO_process	GO:0003097	renal water transport; IDA:UniProtKB.
# GO_process	GO:0006182	cGMP biosynthetic process; IDA:UniProtKB.
# GO_process	GO:0006813	potassium ion transport; ISS:UniProtKB.
# GO_process	GO:0006833	water transport; IDA:UniProtKB.
# GO_process	GO:0006884	cell volume homeostasis; IMP:UniProtKB.
# GO_process	GO:0009992	cellular water homeostasis; IBA:GO_Central.
# GO_process	GO:0015670	carbon dioxide transport; IDA:UniProtKB.
# GO_process	GO:0015696	ammonium transport; IDA:UniProtKB.
# GO_process	GO:0015701	bicarbonate transport; TAS:Reactome.
# GO_process	GO:0015793	glycerol transport; IDA:UniProtKB.
# GO_process	GO:0019725	cellular homeostasis; IDA:UniProtKB.
# GO_process	GO:0021670	lateral ventricle development; IEP:UniProtKB.
# GO_process	GO:0030157	pancreatic juice secretion; IEP:UniProtKB.
# GO_process	GO:0030185	nitric oxide transport; IDA:UniProtKB.
# GO_process	GO:0030950	establishment or maintenance of actin cytoskeleton polarity; IMP:UniProtKB.
# GO_process	GO:0033326	cerebrospinal fluid secretion; IEP:UniProtKB.
# GO_process	GO:0033554	cellular response to stress; IDA:UniProtKB.
# GO_process	GO:0034644	cellular response to UV; IDA:UniProtKB.
# GO_process	GO:0035377	transepithelial water transport; IDA:UniProtKB.
# GO_process	GO:0035378	carbon dioxide transmembrane transport; IDA:UniProtKB.
# GO_process	GO:0042476	odontogenesis; IEP:UniProtKB.
# GO_process	GO:0042493	response to drug; IDA:UniProtKB.
# GO_process	GO:0043066	negative regulation of apoptotic process; IDA:UniProtKB.
# GO_process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB.
# GO_process	GO:0045766	positive regulation of angiogenesis; IMP:UniProtKB.
# GO_process	GO:0046878	positive regulation of saliva secretion; IMP:UniProtKB.
# GO_process	GO:0048146	positive regulation of fibroblast proliferation; IDA:UniProtKB.
# GO_process	GO:0050891	multicellular organismal water homeostasis; IEP:UniProtKB.
# GO_process	GO:0070301	cellular response to hydrogen peroxide; IDA:UniProtKB.
# GO_process	GO:0071241	cellular response to inorganic substance; IDA:UniProtKB.
# GO_process	GO:0071260	cellular response to mechanical stimulus; IDA:UniProtKB.
# GO_process	GO:0071280	cellular response to copper ion; IDA:UniProtKB.
# GO_process	GO:0071288	cellular response to mercury ion; IDA:UniProtKB.
# GO_process	GO:0071300	cellular response to retinoic acid; IDA:UniProtKB.
# GO_process	GO:0071320	cellular response to cAMP; IDA:UniProtKB.
# GO_process	GO:0071456	cellular response to hypoxia; IDA:UniProtKB.
# GO_process	GO:0071472	cellular response to salt stress; IDA:UniProtKB.
# GO_process	GO:0071474	cellular hyperosmotic response; IMP:UniProtKB.
# GO_process	GO:0071549	cellular response to dexamethasone stimulus; IDA:UniProtKB.
# GO_process	GO:0071732	cellular response to nitric oxide; IDA:UniProtKB.
# GO_process	GO:0085018	maintenance of symbiont-containing vacuole by host; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007010	cytoskeleton organization
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.1080.10	-; 1.
# Genevisible	P29972	HS
# HGNC	HGNC:633	AQP1
# INTERACTION	AQP1_HUMAN	Q96JN2-2 CCDC136; NbExp=3; IntAct=EBI-745213, EBI-10171416; Q8IYA8 CCDC36; NbExp=3; IntAct=EBI-745213, EBI-8638439; Q2TAC2 CCDC57; NbExp=3; IntAct=EBI-745213, EBI-2808286; Q9C0F1 CEP44; NbExp=3; IntAct=EBI-745213, EBI-744115; Q9NQ79 CRTAC1; NbExp=3; IntAct=EBI-745213, EBI-10205543; Q96S65 CSRNP1; NbExp=3; IntAct=EBI-745213, EBI-4311573; Q6FG41 FOS; NbExp=3; IntAct=EBI-745213, EBI-10198738; A1L4K1 FSD2; NbExp=3; IntAct=EBI-745213, EBI-5661036; Q9UKS7 IKZF2; NbExp=3; IntAct=EBI-745213, EBI-3893057; Q9UKT9 IKZF3; NbExp=5; IntAct=EBI-745213, EBI-747204; Q7L273 KCTD9; NbExp=3; IntAct=EBI-745213, EBI-4397613; Q8N8K9 KIAA1958; NbExp=3; IntAct=EBI-745213, EBI-10181113; Q15323 KRT31; NbExp=3; IntAct=EBI-745213, EBI-948001; Q14525 KRT33B; NbExp=3; IntAct=EBI-745213, EBI-1049638; Q6A162 KRT40; NbExp=3; IntAct=EBI-745213, EBI-10171697; P60409 KRTAP10-7; NbExp=3; IntAct=EBI-745213, EBI-10172290; Q9BYR5 KRTAP4-2; NbExp=3; IntAct=EBI-745213, EBI-10172511; Q9BYQ4 KRTAP9-2; NbExp=3; IntAct=EBI-745213, EBI-1044640; Q99750 MDFI; NbExp=6; IntAct=EBI-745213, EBI-724076; Q9UJV3-2 MID2; NbExp=3; IntAct=EBI-745213, EBI-10172526; Q5JR59 MTUS2; NbExp=3; IntAct=EBI-745213, EBI-742948; Q7Z3S9 NOTCH2NL; NbExp=5; IntAct=EBI-745213, EBI-945833; Q9UGC6 RGS17; NbExp=5; IntAct=EBI-745213, EBI-3918154; O76081 RGS20; NbExp=3; IntAct=EBI-745213, EBI-1052678; O76081-6 RGS20; NbExp=3; IntAct=EBI-745213, EBI-10178530; Q9UFD9 RIMBP3; NbExp=3; IntAct=EBI-745213, EBI-10182375; Q8IUQ4 SIAH1; NbExp=3; IntAct=EBI-745213, EBI-747107; O43597 SPRY2; NbExp=3; IntAct=EBI-745213, EBI-742487; P15884 TCF4; NbExp=3; IntAct=EBI-745213, EBI-533224; Q07912 TNK2; NbExp=3; IntAct=EBI-745213, EBI-603457; Q13077 TRAF1; NbExp=3; IntAct=EBI-745213, EBI-359224; Q12933 TRAF2; NbExp=3; IntAct=EBI-745213, EBI-355744; P36406 TRIM23; NbExp=5; IntAct=EBI-745213, EBI-740098; Q15654 TRIP6; NbExp=6; IntAct=EBI-745213, EBI-742327; 
# IntAct	P29972	68
# InterPro	IPR000425	MIP
# InterPro	IPR022357	MIP_CS
# InterPro	IPR023271	Aquaporin-like
# InterPro	IPR023274	Aquaporin_1
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04964	Proximal tubule bicarbonate reclamation
# KEGG_Pathway	ko04976	Bile secretion
# MIM	107776	gene
# MIM	110450	phenotype
# MISCELLANEOUS	AQP1_HUMAN	Pharmacologically inhibited by submillimolar concentrations of mercury. 
# Organism	AQP1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR19139	PTHR19139
# PDB	1FQY	X-ray; 3.80 A; A=1-269
# PDB	1H6I	X-ray; 3.54 A; A=1-269
# PDB	1IH5	X-ray; 3.70 A; A=1-269
# PDB	4CSK	X-ray; 3.28 A; A=1-269
# PIR	A41616	A41616
# PIR	I52366	I52366
# POLYMORPHISM	AQP1_HUMAN	AQP1 is responsible for the Colton blood group system. Approximately 92% of Caucasians are Co(A+B-) (Ala-46), approximately 8% are Co(A+B+), and only 0.2% are Co(A-B+) (Val- 46). Co(A-B-) which is very rare, is due to a complete absence of AQP1. 
# PRINTS	PR00783	MINTRINSICP
# PRINTS	PR02013	AQUAPORIN1
# PROSITE	PS00221	MIP
# Pfam	PF00230	MIP
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-1237044	Erythrocytes take up carbon dioxide and release oxygen
# Reactome	R-HSA-1247673	Erythrocytes take up oxygen and release carbon dioxide
# Reactome	R-HSA-432040	Vasopressin regulates renal water homeostasis via Aquaporins
# Reactome	R-HSA-432047	Passive transport by Aquaporins
# RecName	AQP1_HUMAN	Aquaporin-1
# RefSeq	NP_932766	NM_198098.3. [P29972-1]
# SIMILARITY	Belongs to the MIP/aquaporin (TC 1.A.8) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	AQP1_HUMAN	Cell membrane {ECO 0000269|PubMed 23219802}; Multi-pass membrane protein {ECO 0000269|PubMed 23219802}. 
# SUBUNIT	Homotetramer. Interacts with EPHB2; involved in endolymph production in the inner ear (By similarity). Identified in a complex with STOM. {ECO:0000250, ECO	0000269|PubMed:23219802}. 
# SUPFAM	SSF81338	SSF81338
# TCDB	1.A.8.8	the major intrinsic protein (mip) family
# TIGRFAMs	TIGR00861	MIP
# TISSUE SPECIFICITY	Detected in erythrocytes (at protein level). Expressed in a number of tissues including erythrocytes, renal tubules, retinal pigment epithelium, heart, lung, skeletal muscle, kidney and pancreas. Weakly expressed in brain, placenta and liver. {ECO:0000269|PubMed	23219802}. 
# UCSC	uc003tbv	human. [P29972-1]
# WEB RESOURCE	AQP1_HUMAN	Name=Protein Spotlight; Note=Liquid states - Issue 36 of July 2003; URL="http //web.expasy.org/spotlight/back_issues/036";
# WEB RESOURCE	AQP1_HUMAN	Name=SeattleSNPs; URL="http //pga.gs.washington.edu/data/aqp1/"; 
# WEB RESOURCE	AQP1_HUMAN	Name=dbRBC/BGMUT; Note=Blood group antigen gene mutation database; URL="https //www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=colton"; 
# eggNOG	COG0580	LUCA
# eggNOG	KOG0223	Eukaryota
BLAST	swissprot:AQP1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AQP1_HUMAN
BioCyc	ZFISH:ENSG00000106125-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000106125-MONOMER
COXPRESdb	358	http://coxpresdb.jp/data/gene/358.shtml
CleanEx	HS_AQP1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AQP1
DIP	DIP-29607N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29607N
DOI	10.1016/0005-2736(96)00076-4	http://dx.doi.org/10.1016/0005-2736(96)00076-4
DOI	10.1016/S0014-5793(01)02743-0	http://dx.doi.org/10.1016/S0014-5793(01)02743-0
DOI	10.1016/j.bbamem.2012.11.030	http://dx.doi.org/10.1016/j.bbamem.2012.11.030
DOI	10.1038/35036519	http://dx.doi.org/10.1038/35036519
DOI	10.1038/42512	http://dx.doi.org/10.1038/42512
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/nmeth.1273	http://dx.doi.org/10.1038/nmeth.1273
DOI	10.1073/pnas.88.24.11110	http://dx.doi.org/10.1073/pnas.88.24.11110
DOI	10.1073/pnas.98.4.1398	http://dx.doi.org/10.1073/pnas.98.4.1398
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.256.5055.385	http://dx.doi.org/10.1126/science.256.5055.385
DOI	10.1126/science.7521540	http://dx.doi.org/10.1126/science.7521540
DOI	10.1172/JCI117418	http://dx.doi.org/10.1172/JCI117418
DrugBank	DB00819	http://www.drugbank.ca/drugs/DB00819
EMBL	AB451275	http://www.ebi.ac.uk/ena/data/view/AB451275
EMBL	AB451402	http://www.ebi.ac.uk/ena/data/view/AB451402
EMBL	AC004691	http://www.ebi.ac.uk/ena/data/view/AC004691
EMBL	AC005155	http://www.ebi.ac.uk/ena/data/view/AC005155
EMBL	AF480415	http://www.ebi.ac.uk/ena/data/view/AF480415
EMBL	AK309608	http://www.ebi.ac.uk/ena/data/view/AK309608
EMBL	AY953319	http://www.ebi.ac.uk/ena/data/view/AY953319
EMBL	BC022486	http://www.ebi.ac.uk/ena/data/view/BC022486
EMBL	CH471073	http://www.ebi.ac.uk/ena/data/view/CH471073
EMBL	M77829	http://www.ebi.ac.uk/ena/data/view/M77829
EMBL	S73482	http://www.ebi.ac.uk/ena/data/view/S73482
EMBL	U41517	http://www.ebi.ac.uk/ena/data/view/U41517
EMBL	U41518	http://www.ebi.ac.uk/ena/data/view/U41518
Ensembl	ENST00000311813	http://www.ensembl.org/id/ENST00000311813
Ensembl	ENST00000409611	http://www.ensembl.org/id/ENST00000409611
Ensembl	ENST00000409899	http://www.ensembl.org/id/ENST00000409899
Ensembl	ENST00000441328	http://www.ensembl.org/id/ENST00000441328
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005903	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005903
GO_component	GO:0009925	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009925
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0020003	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020003
GO_component	GO:0031526	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031526
GO_component	GO:0031965	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031965
GO_component	GO:0042383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042383
GO_component	GO:0045177	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045177
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005223	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005223
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_function	GO:0005372	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005372
GO_function	GO:0008519	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008519
GO_function	GO:0015079	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015079
GO_function	GO:0015168	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015168
GO_function	GO:0015250	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015250
GO_function	GO:0015254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015254
GO_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GO_function	GO:0030184	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030184
GO_function	GO:0035379	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035379
GO_process	GO:0003091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003091
GO_process	GO:0003097	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003097
GO_process	GO:0006182	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006182
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0006833	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006833
GO_process	GO:0006884	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006884
GO_process	GO:0009992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009992
GO_process	GO:0015670	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015670
GO_process	GO:0015696	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015696
GO_process	GO:0015701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015701
GO_process	GO:0015793	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015793
GO_process	GO:0019725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019725
GO_process	GO:0021670	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021670
GO_process	GO:0030157	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030157
GO_process	GO:0030185	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030185
GO_process	GO:0030950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030950
GO_process	GO:0033326	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033326
GO_process	GO:0033554	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033554
GO_process	GO:0034644	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034644
GO_process	GO:0035377	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035377
GO_process	GO:0035378	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035378
GO_process	GO:0042476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042476
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0043066	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043066
GO_process	GO:0043154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043154
GO_process	GO:0045766	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045766
GO_process	GO:0046878	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046878
GO_process	GO:0048146	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048146
GO_process	GO:0050891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050891
GO_process	GO:0070301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070301
GO_process	GO:0071241	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071241
GO_process	GO:0071260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071260
GO_process	GO:0071280	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071280
GO_process	GO:0071288	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071288
GO_process	GO:0071300	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071300
GO_process	GO:0071320	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071320
GO_process	GO:0071456	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071456
GO_process	GO:0071472	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071472
GO_process	GO:0071474	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071474
GO_process	GO:0071549	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071549
GO_process	GO:0071732	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071732
GO_process	GO:0085018	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0085018
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007010
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.1080.10	http://www.cathdb.info/version/latest/superfamily/1.20.1080.10
GeneCards	AQP1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=AQP1
GeneID	358	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=358
GeneTree	ENSGT00760000119223	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119223
HGNC	HGNC:633	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:633
HOGENOM	HOG000288286	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000288286&db=HOGENOM6
HOVERGEN	HBG000312	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000312&db=HOVERGEN
HPA	CAB001707	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB001707
HPA	HPA019206	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA019206
InParanoid	P29972	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P29972
IntAct	P29972	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P29972*
InterPro	IPR000425	http://www.ebi.ac.uk/interpro/entry/IPR000425
InterPro	IPR022357	http://www.ebi.ac.uk/interpro/entry/IPR022357
InterPro	IPR023271	http://www.ebi.ac.uk/interpro/entry/IPR023271
InterPro	IPR023274	http://www.ebi.ac.uk/interpro/entry/IPR023274
Jabion	358	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=358
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:358	http://www.genome.jp/dbget-bin/www_bget?hsa:358
KEGG_Orthology	KO:K09864	http://www.genome.jp/dbget-bin/www_bget?KO:K09864
KEGG_Pathway	ko04964	http://www.genome.jp/kegg-bin/show_pathway?ko04964
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
MIM	107776	http://www.ncbi.nlm.nih.gov/omim/107776
MIM	110450	http://www.ncbi.nlm.nih.gov/omim/110450
MINT	MINT-1439356	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1439356
OMA	MLICKLA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MLICKLA
OrthoDB	EOG091G166T	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G166T
PANTHER	PTHR19139	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19139
PDB	1FQY	http://www.ebi.ac.uk/pdbe-srv/view/entry/1FQY
PDB	1H6I	http://www.ebi.ac.uk/pdbe-srv/view/entry/1H6I
PDB	1IH5	http://www.ebi.ac.uk/pdbe-srv/view/entry/1IH5
PDB	4CSK	http://www.ebi.ac.uk/pdbe-srv/view/entry/4CSK
PDBsum	1FQY	http://www.ebi.ac.uk/pdbsum/1FQY
PDBsum	1H6I	http://www.ebi.ac.uk/pdbsum/1H6I
PDBsum	1IH5	http://www.ebi.ac.uk/pdbsum/1IH5
PDBsum	4CSK	http://www.ebi.ac.uk/pdbsum/4CSK
PRINTS	PR00783	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00783
PRINTS	PR02013	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR02013
PROSITE	PS00221	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00221
PSORT	swissprot:AQP1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AQP1_HUMAN
PSORT-B	swissprot:AQP1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AQP1_HUMAN
PSORT2	swissprot:AQP1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AQP1_HUMAN
Pfam	PF00230	http://pfam.xfam.org/family/PF00230
PharmGKB	PA24918	http://www.pharmgkb.org/do/serve?objId=PA24918&objCls=Gene
Phobius	swissprot:AQP1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AQP1_HUMAN
PhylomeDB	P29972	http://phylomedb.org/?seqid=P29972
ProteinModelPortal	P29972	http://www.proteinmodelportal.org/query/uniprot/P29972
PubMed	11034202	http://www.ncbi.nlm.nih.gov/pubmed/11034202
PubMed	11171962	http://www.ncbi.nlm.nih.gov/pubmed/11171962
PubMed	11532455	http://www.ncbi.nlm.nih.gov/pubmed/11532455
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	1373524	http://www.ncbi.nlm.nih.gov/pubmed/1373524
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	1722319	http://www.ncbi.nlm.nih.gov/pubmed/1722319
PubMed	19054851	http://www.ncbi.nlm.nih.gov/pubmed/19054851
PubMed	2007592	http://www.ncbi.nlm.nih.gov/pubmed/2007592
PubMed	23219802	http://www.ncbi.nlm.nih.gov/pubmed/23219802
PubMed	7507481	http://www.ncbi.nlm.nih.gov/pubmed/7507481
PubMed	7517253	http://www.ncbi.nlm.nih.gov/pubmed/7517253
PubMed	7518771	http://www.ncbi.nlm.nih.gov/pubmed/7518771
PubMed	7521540	http://www.ncbi.nlm.nih.gov/pubmed/7521540
PubMed	7521882	http://www.ncbi.nlm.nih.gov/pubmed/7521882
PubMed	7677994	http://www.ncbi.nlm.nih.gov/pubmed/7677994
PubMed	8340403	http://www.ncbi.nlm.nih.gov/pubmed/8340403
PubMed	8703970	http://www.ncbi.nlm.nih.gov/pubmed/8703970
PubMed	9177353	http://www.ncbi.nlm.nih.gov/pubmed/9177353
Reactome	R-HSA-1237044	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1237044
Reactome	R-HSA-1247673	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1247673
Reactome	R-HSA-432040	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432040
Reactome	R-HSA-432047	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432047
RefSeq	NP_932766	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_932766
SMR	P29972	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P29972
STRING	9606.ENSP00000311165	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000311165&targetmode=cogs
SUPFAM	SSF81338	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81338
TCDB	1.A.8.8	http://www.tcdb.org/search/result.php?tc=1.A.8.8
TIGRFAMs	TIGR00861	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00861
UCSC	uc003tbv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003tbv&org=rat
UniGene	Hs.76152	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.76152
UniProtKB	AQP1_HUMAN	http://www.uniprot.org/uniprot/AQP1_HUMAN
UniProtKB-AC	P29972	http://www.uniprot.org/uniprot/P29972
charge	swissprot:AQP1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AQP1_HUMAN
eggNOG	COG0580	http://eggnogapi.embl.de/nog_data/html/tree/COG0580
eggNOG	KOG0223	http://eggnogapi.embl.de/nog_data/html/tree/KOG0223
epestfind	swissprot:AQP1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AQP1_HUMAN
garnier	swissprot:AQP1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AQP1_HUMAN
helixturnhelix	swissprot:AQP1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AQP1_HUMAN
hmoment	swissprot:AQP1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AQP1_HUMAN
iep	swissprot:AQP1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AQP1_HUMAN
inforesidue	swissprot:AQP1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AQP1_HUMAN
neXtProt	NX_P29972	http://www.nextprot.org/db/entry/NX_P29972
octanol	swissprot:AQP1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AQP1_HUMAN
pepcoil	swissprot:AQP1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AQP1_HUMAN
pepdigest	swissprot:AQP1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AQP1_HUMAN
pepinfo	swissprot:AQP1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AQP1_HUMAN
pepnet	swissprot:AQP1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AQP1_HUMAN
pepstats	swissprot:AQP1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AQP1_HUMAN
pepwheel	swissprot:AQP1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AQP1_HUMAN
pepwindow	swissprot:AQP1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AQP1_HUMAN
sigcleave	swissprot:AQP1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AQP1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	RUFY1_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=rabip4'; IsoId=Q96T51-1; Sequence=Displayed; Name=2; Synonyms=rabip4; IsoId=Q96T51-2; Sequence=VSP_019785; Name=3; IsoId=Q96T51-3; Sequence=VSP_019786, VSP_019787; Note=No experimental confirmation available.; 
# AltName	RUFY1_HUMAN	FYVE-finger protein EIP1
# AltName	RUFY1_HUMAN	La-binding protein 1
# AltName	RUFY1_HUMAN	Rab4-interacting protein
# AltName	RUFY1_HUMAN	Zinc finger FYVE domain-containing protein 12
# BioGrid	123193	57
# CCDS	CCDS34312	-. [Q96T51-2]
# CCDS	CCDS4445	-. [Q96T51-1]
# ChiTaRS	RUFY1	human
# DOMAIN	RUFY1_HUMAN	The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns(3)P-enriched membranes is substantially increased in acidic conditions. {ECO 0000269|PubMed 19296456}. 
# Ensembl	ENST00000319449	ENSP00000325594; ENSG00000176783. [Q96T51-1]
# Ensembl	ENST00000393438	ENSP00000377087; ENSG00000176783. [Q96T51-2]
# Ensembl	ENST00000437570	ENSP00000390025; ENSG00000176783. [Q96T51-2]
# ExpressionAtlas	Q96T51	baseline and differential
# FUNCTION	RUFY1_HUMAN	Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking. {ECO 0000269|PubMed 14617813}. 
# GO_component	GO:0005634	nucleus; IDA:HPA.
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0031901	early endosome membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_function	GO:0008270	zinc ion binding; IEA:InterPro.
# GO_function	GO:0008289	lipid binding; IEA:UniProtKB-KW.
# GO_function	GO:0008565	protein transporter activity; IEA:Ensembl.
# GO_process	GO:0006897	endocytosis; IEA:UniProtKB-KW.
# GO_process	GO:0030100	regulation of endocytosis; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0008289	lipid binding
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# Gene3D	3.30.40.10	-; 1.
# Genevisible	Q96T51	HS
# HGNC	HGNC:19760	RUFY1
# INTERACTION	RUFY1_HUMAN	Q68CQ4 DIEXF; NbExp=3; IntAct=EBI-3941207, EBI-747711; O75928 PIAS2; NbExp=3; IntAct=EBI-3941207, EBI-348555; Q96DA2 RAB39B; NbExp=3; IntAct=EBI-3941207, EBI-9089467; Q96QF0 RAB3IP; NbExp=3; IntAct=EBI-3941207, EBI-747844; Q9BRA2 TXNDC17; NbExp=3; IntAct=EBI-3941207, EBI-1055906; 
# IntAct	Q96T51	14
# InterPro	IPR000306	Znf_FYVE
# InterPro	IPR001841	Znf_RING
# InterPro	IPR004012	Run_dom
# InterPro	IPR011011	Znf_FYVE_PHD
# InterPro	IPR013083	Znf_RING/FYVE/PHD
# InterPro	IPR017455	Znf_FYVE-rel
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Pathway	ko04144	Endocytosis
# MIM	610327	gene
# Organism	RUFY1_HUMAN	Homo sapiens (Human)
# PDB	2YQM	NMR; -; A=627-708
# PDB	2YW8	X-ray; 3.00 A; A=627-708
# PROSITE	PS50178	ZF_FYVE
# PROSITE	PS50826	RUN
# PTM	RUFY1_HUMAN	Phosphorylation on Tyr-389 and/or Tyr-400 is required for interaction with BMX and endosomal targeting. {ECO 0000269|PubMed 11877430}. 
# Pfam	PF01363	FYVE
# Pfam	PF02759	RUN
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-1660499	Synthesis of PIPs at the plasma membrane
# RecName	RUFY1_HUMAN	RUN and FYVE domain-containing protein 1
# RefSeq	NP_001035541	NM_001040451.2. [Q96T51-2]
# RefSeq	NP_001035542	NM_001040452.2. [Q96T51-2]
# RefSeq	NP_079434	NM_025158.4. [Q96T51-1]
# RefSeq	XP_016865384	XM_017009895.1
# SEQUENCE CAUTION	Sequence=AAK50771.1; Type=Frameshift; Positions=47, 88; Evidence={ECO:0000305}; Sequence=BAB15276.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Contains 1 FYVE-type zinc finger. {ECO:0000255|PROSITE-ProRule	PRU00091}. 
# SIMILARITY	Contains 1 RUN domain. {ECO:0000255|PROSITE- ProRule	PRU00178}. 
# SMART	SM00064	FYVE
# SMART	SM00593	RUN
# SUBCELLULAR LOCATION	RUFY1_HUMAN	Cytoplasm. Early endosome membrane; Peripheral membrane protein. 
# SUBUNIT	RUFY1_HUMAN	Interacts with BMX. May interact with SSB. Interacts with RAB4 and RAB5 that have been activated by GTP-binding. {ECO 0000269|PubMed 11877430, ECO 0000269|PubMed 14617813}. 
# SUPFAM	SSF57903	SSF57903
# TISSUE SPECIFICITY	Broadly expressed, with highest levels in lung, testis, kidney and brain. {ECO:0000269|PubMed	11877430}. 
# UCSC	uc003mka	human. [Q96T51-1]
# eggNOG	ENOG410XRAX	LUCA
# eggNOG	KOG1729	Eukaryota
# eggNOG	KOG4381	Eukaryota
BLAST	swissprot:RUFY1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:RUFY1_HUMAN
BioCyc	ZFISH:ENSG00000176783-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000176783-MONOMER
COXPRESdb	80230	http://coxpresdb.jp/data/gene/80230.shtml
CleanEx	HS_RUFY1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_RUFY1
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1002/prot.22392	http://dx.doi.org/10.1002/prot.22392
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M111933200	http://dx.doi.org/10.1074/jbc.M111933200
DOI	10.1091/mbc.E03-05-0343	http://dx.doi.org/10.1091/mbc.E03-05-0343
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AB209507	http://www.ebi.ac.uk/ena/data/view/AB209507
EMBL	AF312367	http://www.ebi.ac.uk/ena/data/view/AF312367
EMBL	AF361055	http://www.ebi.ac.uk/ena/data/view/AF361055
EMBL	AK025904	http://www.ebi.ac.uk/ena/data/view/AK025904
EMBL	AK075021	http://www.ebi.ac.uk/ena/data/view/AK075021
EMBL	BC032571	http://www.ebi.ac.uk/ena/data/view/BC032571
Ensembl	ENST00000319449	http://www.ensembl.org/id/ENST00000319449
Ensembl	ENST00000393438	http://www.ensembl.org/id/ENST00000393438
Ensembl	ENST00000437570	http://www.ensembl.org/id/ENST00000437570
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0031901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031901
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0008270	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270
GO_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0006897	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006897
GO_process	GO:0030100	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030100
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
Gene3D	3.30.40.10	http://www.cathdb.info/version/latest/superfamily/3.30.40.10
GeneCards	RUFY1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=RUFY1
GeneID	80230	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80230
GeneTree	ENSGT00550000074558	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074558
HGNC	HGNC:19760	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:19760
HOVERGEN	HBG057053	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG057053&db=HOVERGEN
HPA	HPA038804	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA038804
HPA	HPA057614	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA057614
InParanoid	Q96T51	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96T51
IntAct	Q96T51	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96T51*
InterPro	IPR000306	http://www.ebi.ac.uk/interpro/entry/IPR000306
InterPro	IPR001841	http://www.ebi.ac.uk/interpro/entry/IPR001841
InterPro	IPR004012	http://www.ebi.ac.uk/interpro/entry/IPR004012
InterPro	IPR011011	http://www.ebi.ac.uk/interpro/entry/IPR011011
InterPro	IPR013083	http://www.ebi.ac.uk/interpro/entry/IPR013083
InterPro	IPR017455	http://www.ebi.ac.uk/interpro/entry/IPR017455
Jabion	80230	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=80230
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Gene	hsa:80230	http://www.genome.jp/dbget-bin/www_bget?hsa:80230
KEGG_Orthology	KO:K12482	http://www.genome.jp/dbget-bin/www_bget?KO:K12482
KEGG_Pathway	ko04144	http://www.genome.jp/kegg-bin/show_pathway?ko04144
MIM	610327	http://www.ncbi.nlm.nih.gov/omim/610327
MINT	MINT-7302811	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-7302811
OMA	AILDQKH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AILDQKH
OrthoDB	EOG091G042J	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G042J
PDB	2YQM	http://www.ebi.ac.uk/pdbe-srv/view/entry/2YQM
PDB	2YW8	http://www.ebi.ac.uk/pdbe-srv/view/entry/2YW8
PDBsum	2YQM	http://www.ebi.ac.uk/pdbsum/2YQM
PDBsum	2YW8	http://www.ebi.ac.uk/pdbsum/2YW8
PROSITE	PS50178	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50178
PROSITE	PS50826	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50826
PSORT	swissprot:RUFY1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:RUFY1_HUMAN
PSORT-B	swissprot:RUFY1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:RUFY1_HUMAN
PSORT2	swissprot:RUFY1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:RUFY1_HUMAN
Pfam	PF01363	http://pfam.xfam.org/family/PF01363
Pfam	PF02759	http://pfam.xfam.org/family/PF02759
PharmGKB	PA134944787	http://www.pharmgkb.org/do/serve?objId=PA134944787&objCls=Gene
Phobius	swissprot:RUFY1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:RUFY1_HUMAN
PhylomeDB	Q96T51	http://phylomedb.org/?seqid=Q96T51
ProteinModelPortal	Q96T51	http://www.proteinmodelportal.org/query/uniprot/Q96T51
PubMed	11877430	http://www.ncbi.nlm.nih.gov/pubmed/11877430
PubMed	14617813	http://www.ncbi.nlm.nih.gov/pubmed/14617813
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	19296456	http://www.ncbi.nlm.nih.gov/pubmed/19296456
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-1660499	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1660499
RefSeq	NP_001035541	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001035541
RefSeq	NP_001035542	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001035542
RefSeq	NP_079434	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_079434
RefSeq	XP_016865384	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016865384
SMART	SM00064	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00064
SMART	SM00593	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00593
SMR	Q96T51	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q96T51
STRING	9606.ENSP00000325594	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000325594&targetmode=cogs
SUPFAM	SSF57903	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF57903
UCSC	uc003mka	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003mka&org=rat
UniGene	Hs.306769	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.306769
UniProtKB	RUFY1_HUMAN	http://www.uniprot.org/uniprot/RUFY1_HUMAN
UniProtKB-AC	Q96T51	http://www.uniprot.org/uniprot/Q96T51
charge	swissprot:RUFY1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:RUFY1_HUMAN
eggNOG	ENOG410XRAX	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRAX
eggNOG	KOG1729	http://eggnogapi.embl.de/nog_data/html/tree/KOG1729
eggNOG	KOG4381	http://eggnogapi.embl.de/nog_data/html/tree/KOG4381
epestfind	swissprot:RUFY1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:RUFY1_HUMAN
garnier	swissprot:RUFY1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:RUFY1_HUMAN
helixturnhelix	swissprot:RUFY1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:RUFY1_HUMAN
hmoment	swissprot:RUFY1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:RUFY1_HUMAN
iep	swissprot:RUFY1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:RUFY1_HUMAN
inforesidue	swissprot:RUFY1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:RUFY1_HUMAN
neXtProt	NX_Q96T51	http://www.nextprot.org/db/entry/NX_Q96T51
octanol	swissprot:RUFY1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:RUFY1_HUMAN
pepcoil	swissprot:RUFY1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:RUFY1_HUMAN
pepdigest	swissprot:RUFY1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:RUFY1_HUMAN
pepinfo	swissprot:RUFY1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:RUFY1_HUMAN
pepnet	swissprot:RUFY1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:RUFY1_HUMAN
pepstats	swissprot:RUFY1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:RUFY1_HUMAN
pepwheel	swissprot:RUFY1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:RUFY1_HUMAN
pepwindow	swissprot:RUFY1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:RUFY1_HUMAN
sigcleave	swissprot:RUFY1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:RUFY1_HUMAN
## Database	ID	URL or Descriptions
# Ensembl	ENST00000359963	ENSP00000353048; ENSG00000198445
# FUNCTION	TCPQM_HUMAN	Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis. {ECO 0000250}. 
# GO_component	GO:0005737	cytoplasm; IEA:UniProtKB-SubCell.
# GO_function	GO:0005253	anion channel activity; TAS:ProtInc.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0015269	calcium-activated potassium channel activity; TAS:ProtInc.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GOslim_component	GO:0005737	cytoplasm
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# Gene3D	1.10.560.10	-; 2.
# Gene3D	3.30.260.10	-; 2.
# Gene3D	3.50.7.10	-; 1.
# Genevisible	Q96SF2	HS
# HGNC	HGNC:15553	CCT8L2
# InterPro	IPR002423	Cpn60/TCP-1
# InterPro	IPR017998	Chaperone_TCP-1
# InterPro	IPR027409	GroEL-like_apical_dom
# InterPro	IPR027410	TCP-1-like_intermed
# InterPro	IPR027413	GROEL-like_equatorial
# MISCELLANEOUS	Expression of CCT8L2 is confirmed by many ESTs mostly identified from the testis. {ECO:0000305|PubMed	20193073}. 
# MISCELLANEOUS	Presence of two highly similar CCT8L genes (CCT8L1P and CCT8L2) in the genomes of human and chimp and of a single copy in other mammal genomes, including rhesus monkey, suggests that the duplication of this gene occurred in the ape lineage (Hominoidea) after its divergence from the old-world monkeys (Cercopithecidae). {ECO:0000303|PubMed	20193073}. 
# Organism	TCPQM_HUMAN	Homo sapiens (Human)
# PRINTS	PR00304	TCOMPLEXTCP1
# Pfam	PF00118	Cpn60_TCP1
# Proteomes	UP000005640	Chromosome 22
# RecName	TCPQM_HUMAN	T-complex protein 1 subunit theta-like 2
# RefSeq	NP_055221	NM_014406.4
# SEQUENCE CAUTION	Sequence=AAI39843.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the TCP-1 chaperonin family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	TCPQM_HUMAN	Cytoplasm {ECO 0000250}. 
# SUPFAM	SSF52029	SSF52029
# UCSC	uc002zlp	human
# eggNOG	ENOG410XPXR	LUCA
# eggNOG	KOG0362	Eukaryota
BLAST	swissprot:TCPQM_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TCPQM_HUMAN
BioCyc	ZFISH:G66-33823-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33823-MONOMER
COXPRESdb	150160	http://coxpresdb.jp/data/gene/150160.shtml
CleanEx	HS_CCT8L2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CCT8L2
DOI	10.1006/geno.1999.5975	http://dx.doi.org/10.1006/geno.1999.5975
DOI	10.1038/990031	http://dx.doi.org/10.1038/990031
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2148-10-64	http://dx.doi.org/10.1186/1471-2148-10-64
DOI	10.1186/gb-2004-5-10-r84	http://dx.doi.org/10.1186/gb-2004-5-10-r84
EMBL	AP000365	http://www.ebi.ac.uk/ena/data/view/AP000365
EMBL	AP000547	http://www.ebi.ac.uk/ena/data/view/AP000547
EMBL	AP003553	http://www.ebi.ac.uk/ena/data/view/AP003553
EMBL	BC033797	http://www.ebi.ac.uk/ena/data/view/BC033797
EMBL	BC100811	http://www.ebi.ac.uk/ena/data/view/BC100811
EMBL	BC100812	http://www.ebi.ac.uk/ena/data/view/BC100812
EMBL	BC100813	http://www.ebi.ac.uk/ena/data/view/BC100813
EMBL	BC139842	http://www.ebi.ac.uk/ena/data/view/BC139842
EMBL	CH471193	http://www.ebi.ac.uk/ena/data/view/CH471193
EMBL	CR456508	http://www.ebi.ac.uk/ena/data/view/CR456508
Ensembl	ENST00000359963	http://www.ensembl.org/id/ENST00000359963
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_function	GO:0005253	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005253
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0015269	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015269
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
Gene3D	1.10.560.10	http://www.cathdb.info/version/latest/superfamily/1.10.560.10
Gene3D	3.30.260.10	http://www.cathdb.info/version/latest/superfamily/3.30.260.10
Gene3D	3.50.7.10	http://www.cathdb.info/version/latest/superfamily/3.50.7.10
GeneCards	CCT8L2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCT8L2
GeneID	150160	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=150160
GeneTree	ENSGT00550000074783	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074783
HGNC	HGNC:15553	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:15553
HOGENOM	HOG000131368	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000131368&db=HOGENOM6
HOVERGEN	HBG098338	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG098338&db=HOVERGEN
HPA	HPA039268	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA039268
HPA	HPA041336	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA041336
HPA	HPA045440	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA045440
InParanoid	Q96SF2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96SF2
IntAct	Q96SF2	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96SF2*
InterPro	IPR002423	http://www.ebi.ac.uk/interpro/entry/IPR002423
InterPro	IPR017998	http://www.ebi.ac.uk/interpro/entry/IPR017998
InterPro	IPR027409	http://www.ebi.ac.uk/interpro/entry/IPR027409
InterPro	IPR027410	http://www.ebi.ac.uk/interpro/entry/IPR027410
InterPro	IPR027413	http://www.ebi.ac.uk/interpro/entry/IPR027413
Jabion	150160	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=150160
KEGG_Gene	hsa:150160	http://www.genome.jp/dbget-bin/www_bget?hsa:150160
OMA	QLCQDPR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QLCQDPR
OrthoDB	EOG091G05LP	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05LP
PRINTS	PR00304	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00304
PSORT	swissprot:TCPQM_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TCPQM_HUMAN
PSORT-B	swissprot:TCPQM_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TCPQM_HUMAN
PSORT2	swissprot:TCPQM_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TCPQM_HUMAN
Pfam	PF00118	http://pfam.xfam.org/family/PF00118
PharmGKB	PA162382100	http://www.pharmgkb.org/do/serve?objId=PA162382100&objCls=Gene
Phobius	swissprot:TCPQM_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TCPQM_HUMAN
PhylomeDB	Q96SF2	http://phylomedb.org/?seqid=Q96SF2
ProteinModelPortal	Q96SF2	http://www.proteinmodelportal.org/query/uniprot/Q96SF2
PubMed	10585773	http://www.ncbi.nlm.nih.gov/pubmed/10585773
PubMed	10591208	http://www.ncbi.nlm.nih.gov/pubmed/10591208
PubMed	15461802	http://www.ncbi.nlm.nih.gov/pubmed/15461802
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	20193073	http://www.ncbi.nlm.nih.gov/pubmed/20193073
RefSeq	NP_055221	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055221
STRING	9606.ENSP00000353048	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000353048&targetmode=cogs
SUPFAM	SSF52029	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52029
UCSC	uc002zlp	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002zlp&org=rat
UniGene	Hs.128342	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.128342
UniProtKB	TCPQM_HUMAN	http://www.uniprot.org/uniprot/TCPQM_HUMAN
UniProtKB-AC	Q96SF2	http://www.uniprot.org/uniprot/Q96SF2
charge	swissprot:TCPQM_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TCPQM_HUMAN
eggNOG	ENOG410XPXR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPXR
eggNOG	KOG0362	http://eggnogapi.embl.de/nog_data/html/tree/KOG0362
epestfind	swissprot:TCPQM_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TCPQM_HUMAN
garnier	swissprot:TCPQM_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TCPQM_HUMAN
helixturnhelix	swissprot:TCPQM_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TCPQM_HUMAN
hmoment	swissprot:TCPQM_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TCPQM_HUMAN
iep	swissprot:TCPQM_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TCPQM_HUMAN
inforesidue	swissprot:TCPQM_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TCPQM_HUMAN
neXtProt	NX_Q96SF2	http://www.nextprot.org/db/entry/NX_Q96SF2
octanol	swissprot:TCPQM_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TCPQM_HUMAN
pepcoil	swissprot:TCPQM_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TCPQM_HUMAN
pepdigest	swissprot:TCPQM_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TCPQM_HUMAN
pepinfo	swissprot:TCPQM_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TCPQM_HUMAN
pepnet	swissprot:TCPQM_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TCPQM_HUMAN
pepstats	swissprot:TCPQM_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TCPQM_HUMAN
pepwheel	swissprot:TCPQM_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TCPQM_HUMAN
pepwindow	swissprot:TCPQM_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TCPQM_HUMAN
sigcleave	swissprot:TCPQM_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TCPQM_HUMAN
## Database	ID	URL or Descriptions
# AltName	AK1C4_HUMAN	3-alpha-HSD1
# AltName	AK1C4_HUMAN	3-alpha-hydroxysteroid dehydrogenase type I
# AltName	AK1C4_HUMAN	Chlordecone reductase
# AltName	AK1C4_HUMAN	Dihydrodiol dehydrogenase 4
# AltName	AK1C4_HUMAN	HAKRA
# BRENDA	1.1.1.357	2681
# BioGrid	107534	4
# CATALYTIC ACTIVITY	AK1C4_HUMAN	A 3-alpha-hydroxysteroid + NAD(P)(+) = a 3- oxosteroid + NAD(P)H. 
# CATALYTIC ACTIVITY	AK1C4_HUMAN	Chlordecone alcohol + NADP(+) = chlordecone + NADPH. 
# CDD	cd06660	Aldo_ket_red
# DISEASE	AK1C4_HUMAN	46,XY sex reversal 8 (SRXY8) [MIM 614279]  A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. {ECO 0000269|PubMed 21802064}. Note=The gene represented in this entry may act as a disease modifier. A splicing mutation resulting in loss of AKR1C4 exon 2 has been found in affected individuals carrying a causative mutation in AKR1C2 (PubMed 21802064). These patients manifest a more severe disease phenotype than individuals only carrying mutations in AKR1C2. {ECO 0000269|PubMed 21802064}. 
# Ensembl	ENST00000263126	ENSP00000263126; ENSG00000198610
# Ensembl	ENST00000380448	ENSP00000369814; ENSG00000198610
# FUNCTION	AK1C4_HUMAN	Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha- androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20- alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route. 
# GO_component	GO:0005737	cytoplasm; TAS:ProtInc.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0001758	retinal dehydrogenase activity; IDA:UniProtKB.
# GO_function	GO:0004033	aldo-keto reductase (NADP) activity; TAS:Reactome.
# GO_function	GO:0009055	electron carrier activity; TAS:UniProtKB.
# GO_function	GO:0015125	bile acid transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IDA:UniProtKB.
# GO_function	GO:0047023	androsterone dehydrogenase activity; IDA:UniProtKB.
# GO_function	GO:0047743	chlordecone reductase activity; IEA:UniProtKB-EC.
# GO_process	GO:0001523	retinoid metabolic process; TAS:Reactome.
# GO_process	GO:0006699	bile acid biosynthetic process; TAS:Reactome.
# GO_process	GO:0008202	steroid metabolic process; TAS:ProtInc.
# GO_process	GO:0008209	androgen metabolic process; TAS:ProtInc.
# GO_process	GO:0015721	bile acid and bile salt transport; TAS:ProtInc.
# GO_process	GO:0044597	daunorubicin metabolic process; IMP:UniProtKB.
# GO_process	GO:0044598	doxorubicin metabolic process; IMP:UniProtKB.
# GO_process	GO:0071395	cellular response to jasmonic acid stimulus; IDA:UniProtKB.
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0019748	secondary metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0051186	cofactor metabolic process
# Gene3D	3.20.20.100	-; 1.
# Genevisible	P17516	HS
# HGNC	HGNC:387	AKR1C4
# InterPro	IPR001395	Aldo/ket_red/Kv-b
# InterPro	IPR018170	Aldo/ket_reductase_CS
# InterPro	IPR020471	Aldo/keto_reductase
# InterPro	IPR023210	NADP_OxRdtase_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00980	Metabolism of xenobiotics by cytochrome P450
# MIM	600451	gene
# MIM	614279	phenotype
# Organism	AK1C4_HUMAN	Homo sapiens (Human)
# Orphanet	90796	46,XY disorder of sex development due to isolated 17,20 lyase deficiency
# PANTHER	PTHR11732	PTHR11732; 2
# PDB	2FVL	X-ray; 2.40 A; A/B/C=1-323
# PIR	A57407	A57407
# PIR	S59620	S59620
# PIRSF	PIRSF000097	AKR
# POLYMORPHISM	AK1C4_HUMAN	The allele with Cys-145/Val-311 shows a three- to five-fold decrease in catalytic efficiency for xenobiotic and steroidal substrates compared to the Ser-145/Leu-311 allele. 
# PRINTS	PR00069	ALDKETRDTASE
# PROSITE	PS00062	ALDOKETO_REDUCTASE_2
# PROSITE	PS00063	ALDOKETO_REDUCTASE_3
# PROSITE	PS00798	ALDOKETO_REDUCTASE_1
# PTM	AK1C4_HUMAN	The N-terminus is blocked. 
# Pfam	PF00248	Aldo_ket_red
# Proteomes	UP000005640	Chromosome 10
# Reactome	R-HSA-193368	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
# Reactome	R-HSA-193775	Synthesis of bile acids and bile salts via 24-hydroxycholesterol
# Reactome	R-HSA-193807	Synthesis of bile acids and bile salts via 27-hydroxycholesterol
# Reactome	R-HSA-975634	Retinoid metabolism and transport
# RecName	AK1C4_HUMAN	Aldo-keto reductase family 1 member C4
# RefSeq	NP_001809	NM_001818.3
# SEQUENCE CAUTION	Sequence=AAA35658.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the aldo/keto reductase family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	AK1C4_HUMAN	Cytoplasm. 
# SUBUNIT	Monomer. {ECO	0000269|Ref.14}. 
# SUPFAM	SSF51430	SSF51430
# TISSUE SPECIFICITY	AK1C4_HUMAN	Liver specific. {ECO 0000269|PubMed 11158055, ECO 0000269|PubMed 7650035}. 
# UCSC	uc001ihw	human
# eggNOG	COG0656	LUCA
# eggNOG	KOG1577	Eukaryota
BLAST	swissprot:AK1C4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AK1C4_HUMAN
BioCyc	MetaCyc:HS10739-MONOMER	http://biocyc.org/getid?id=MetaCyc:HS10739-MONOMER
BioCyc	ZFISH:HS10739-MONOMER	http://biocyc.org/getid?id=ZFISH:HS10739-MONOMER
COXPRESdb	1109	http://coxpresdb.jp/data/gene/1109.shtml
CleanEx	HS_AKR1C4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AKR1C4
DOI	10.1016/0006-291X(92)91260-W	http://dx.doi.org/10.1016/0006-291X(92)91260-W
DOI	10.1016/0960-0760(93)90308-J	http://dx.doi.org/10.1016/0960-0760(93)90308-J
DOI	10.1016/0960-0760(95)00019-V	http://dx.doi.org/10.1016/0960-0760(95)00019-V
DOI	10.1016/j.ajhg.2011.06.009	http://dx.doi.org/10.1016/j.ajhg.2011.06.009
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/bi00456a034	http://dx.doi.org/10.1021/bi00456a034
DOI	10.1038/nature02462	http://dx.doi.org/10.1038/nature02462
DOI	10.1042/bj2990545	http://dx.doi.org/10.1042/bj2990545
DOI	10.1046/j.1365-2443.2000.00310.x	http://dx.doi.org/10.1046/j.1365-2443.2000.00310.x
DOI	10.1074/jbc.270.34.20162	http://dx.doi.org/10.1074/jbc.270.34.20162
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1210/jcem.86.2.7216	http://dx.doi.org/10.1210/jcem.86.2.7216
EC_number	EC:1.1.1.-	http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.-
EC_number	EC:1.1.1.225	http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.225
EC_number	EC:1.1.1.357	http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.357
EMBL	AB031085	http://www.ebi.ac.uk/ena/data/view/AB031085
EMBL	AB032163	http://www.ebi.ac.uk/ena/data/view/AB032163
EMBL	AB045829	http://www.ebi.ac.uk/ena/data/view/AB045829
EMBL	AL355303	http://www.ebi.ac.uk/ena/data/view/AL355303
EMBL	BC020744	http://www.ebi.ac.uk/ena/data/view/BC020744
EMBL	D26125	http://www.ebi.ac.uk/ena/data/view/D26125
EMBL	M33375	http://www.ebi.ac.uk/ena/data/view/M33375
EMBL	S68287	http://www.ebi.ac.uk/ena/data/view/S68287
ENZYME	1.1.1.-	http://enzyme.expasy.org/EC/1.1.1.-
ENZYME	1.1.1.225	http://enzyme.expasy.org/EC/1.1.1.225
ENZYME	1.1.1.357	http://enzyme.expasy.org/EC/1.1.1.357
Ensembl	ENST00000263126	http://www.ensembl.org/id/ENST00000263126
Ensembl	ENST00000380448	http://www.ensembl.org/id/ENST00000380448
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0001758	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001758
GO_function	GO:0004033	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004033
GO_function	GO:0009055	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055
GO_function	GO:0015125	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015125
GO_function	GO:0016655	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016655
GO_function	GO:0047023	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047023
GO_function	GO:0047743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047743
GO_process	GO:0001523	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001523
GO_process	GO:0006699	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006699
GO_process	GO:0008202	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008202
GO_process	GO:0008209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008209
GO_process	GO:0015721	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015721
GO_process	GO:0044597	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044597
GO_process	GO:0044598	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044598
GO_process	GO:0071395	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071395
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0019748	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019748
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0051186	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186
Gene3D	3.20.20.100	http://www.cathdb.info/version/latest/superfamily/3.20.20.100
GeneCards	AKR1C4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=AKR1C4
GeneID	1109	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1109
GeneTree	ENSGT00760000119041	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119041
HGNC	HGNC:387	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:387
HOGENOM	HOG000250272	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000250272&db=HOGENOM6
HOVERGEN	HBG000020	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000020&db=HOVERGEN
HPA	HPA044720	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA044720
InParanoid	P17516	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P17516
IntEnz	1.1.1	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1
IntEnz	1.1.1.225	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.225
IntEnz	1.1.1.357	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.357
InterPro	IPR001395	http://www.ebi.ac.uk/interpro/entry/IPR001395
InterPro	IPR018170	http://www.ebi.ac.uk/interpro/entry/IPR018170
InterPro	IPR020471	http://www.ebi.ac.uk/interpro/entry/IPR020471
InterPro	IPR023210	http://www.ebi.ac.uk/interpro/entry/IPR023210
Jabion	1109	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1109
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:1109	http://www.genome.jp/dbget-bin/www_bget?hsa:1109
KEGG_Orthology	KO:K00212	http://www.genome.jp/dbget-bin/www_bget?KO:K00212
KEGG_Pathway	ko00980	http://www.genome.jp/kegg-bin/show_pathway?ko00980
KEGG_Reaction	rn:R07015	http://www.genome.jp/dbget-bin/www_bget?rn:R07015
KEGG_Reaction	rn:R09420	http://www.genome.jp/dbget-bin/www_bget?rn:R09420
MIM	600451	http://www.ncbi.nlm.nih.gov/omim/600451
MIM	614279	http://www.ncbi.nlm.nih.gov/omim/614279
OMA	LLHFPMA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LLHFPMA
Orphanet	90796	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=90796
OrthoDB	EOG091G0D69	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0D69
PANTHER	PTHR11732	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11732
PDB	2FVL	http://www.ebi.ac.uk/pdbe-srv/view/entry/2FVL
PDBsum	2FVL	http://www.ebi.ac.uk/pdbsum/2FVL
PRINTS	PR00069	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00069
PROSITE	PS00062	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00062
PROSITE	PS00063	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00063
PROSITE	PS00798	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00798
PSORT	swissprot:AK1C4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AK1C4_HUMAN
PSORT-B	swissprot:AK1C4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AK1C4_HUMAN
PSORT2	swissprot:AK1C4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AK1C4_HUMAN
Pfam	PF00248	http://pfam.xfam.org/family/PF00248
PharmGKB	PA24680	http://www.pharmgkb.org/do/serve?objId=PA24680&objCls=Gene
Phobius	swissprot:AK1C4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AK1C4_HUMAN
PhylomeDB	P17516	http://phylomedb.org/?seqid=P17516
ProteinModelPortal	P17516	http://www.proteinmodelportal.org/query/uniprot/P17516
PubMed	10634139	http://www.ncbi.nlm.nih.gov/pubmed/10634139
PubMed	10672042	http://www.ncbi.nlm.nih.gov/pubmed/10672042
PubMed	11158055	http://www.ncbi.nlm.nih.gov/pubmed/11158055
PubMed	15164054	http://www.ncbi.nlm.nih.gov/pubmed/15164054
PubMed	1530633	http://www.ncbi.nlm.nih.gov/pubmed/1530633
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21802064	http://www.ncbi.nlm.nih.gov/pubmed/21802064
PubMed	2187532	http://www.ncbi.nlm.nih.gov/pubmed/2187532
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	7626489	http://www.ncbi.nlm.nih.gov/pubmed/7626489
PubMed	7650035	http://www.ncbi.nlm.nih.gov/pubmed/7650035
PubMed	8172617	http://www.ncbi.nlm.nih.gov/pubmed/8172617
PubMed	8274401	http://www.ncbi.nlm.nih.gov/pubmed/8274401
Reactome	R-HSA-193368	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-193368
Reactome	R-HSA-193775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-193775
Reactome	R-HSA-193807	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-193807
Reactome	R-HSA-975634	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-975634
RefSeq	NP_001809	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001809
SMR	P17516	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P17516
STRING	9606.ENSP00000263126	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000263126&targetmode=cogs
SUPFAM	SSF51430	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51430
UCSC	uc001ihw	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001ihw&org=rat
UniGene	Hs.567245	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.567245
UniProtKB	AK1C4_HUMAN	http://www.uniprot.org/uniprot/AK1C4_HUMAN
UniProtKB-AC	P17516	http://www.uniprot.org/uniprot/P17516
charge	swissprot:AK1C4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AK1C4_HUMAN
eggNOG	COG0656	http://eggnogapi.embl.de/nog_data/html/tree/COG0656
eggNOG	KOG1577	http://eggnogapi.embl.de/nog_data/html/tree/KOG1577
epestfind	swissprot:AK1C4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AK1C4_HUMAN
garnier	swissprot:AK1C4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AK1C4_HUMAN
helixturnhelix	swissprot:AK1C4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AK1C4_HUMAN
hmoment	swissprot:AK1C4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AK1C4_HUMAN
iep	swissprot:AK1C4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AK1C4_HUMAN
inforesidue	swissprot:AK1C4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AK1C4_HUMAN
neXtProt	NX_P17516	http://www.nextprot.org/db/entry/NX_P17516
octanol	swissprot:AK1C4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AK1C4_HUMAN
pepcoil	swissprot:AK1C4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AK1C4_HUMAN
pepdigest	swissprot:AK1C4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AK1C4_HUMAN
pepinfo	swissprot:AK1C4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AK1C4_HUMAN
pepnet	swissprot:AK1C4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AK1C4_HUMAN
pepstats	swissprot:AK1C4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AK1C4_HUMAN
pepwheel	swissprot:AK1C4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AK1C4_HUMAN
pepwindow	swissprot:AK1C4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AK1C4_HUMAN
sigcleave	swissprot:AK1C4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AK1C4_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNE4_HUMAN	MinK-related peptide 3
# AltName	KCNE4_HUMAN	Minimum potassium ion channel-related peptide 3
# AltName	KCNE4_HUMAN	Potassium channel subunit beta MiRP3
# BioGrid	117217	5
# Ensembl	ENST00000281830	ENSP00000281830; ENSG00000152049
# FUNCTION	KCNE4_HUMAN	Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current. 
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0016324	apical plasma membrane; IEA:Ensembl.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IEA:InterPro.
# GO_function	GO:0044325	ion channel binding; IPI:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# Genevisible	Q8WWG9	HS
# HGNC	HGNC:6244	KCNE4
# InterPro	IPR000369	K_chnl_KCNE
# KEGG_Brite	ko04040	Ion channels
# MIM	607775	gene
# Organism	KCNE4_HUMAN	Homo sapiens (Human)
# PRINTS	PR00168	KCNECHANNEL
# Pfam	PF02060	ISK_Channel
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-5576890	Phase 3 - rapid repolarisation
# Reactome	R-HSA-5576893	Phase 2 - plateau phase
# RecName	KCNE4_HUMAN	Potassium voltage-gated channel subfamily E member 4
# RefSeq	NP_542402	NM_080671.3
# SEQUENCE CAUTION	Sequence=AAH14429.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAL49979.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the potassium channel KCNE family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	KCNE4_HUMAN	Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. 
# SUBUNIT	KCNE4_HUMAN	Interacts with KCNQ1; impairs KCNQ1 localization in lipid rafts and inhibits voltage-gated potassium channel activity. {ECO 0000269|PubMed 12096056, ECO 0000269|PubMed 19687231, ECO 0000269|PubMed 20533308}. 
# TISSUE SPECIFICITY	Predominantly expressed in embryo and adult uterus. Low expression found in kidney, small intestine, lung and heart. {ECO:0000269|PubMed	12096056}. 
# UCSC	uc002vnl	human
# eggNOG	ENOG410IWSX	Eukaryota
# eggNOG	ENOG41129VY	LUCA
BLAST	swissprot:KCNE4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNE4_HUMAN
BioCyc	ZFISH:ENSG00000152049-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000152049-MONOMER
COXPRESdb	23704	http://coxpresdb.jp/data/gene/23704.shtml
CleanEx	HS_KCNE4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNE4
DOI	10.1002/jcp.22265	http://dx.doi.org/10.1002/jcp.22265
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1085/jgp.200910234	http://dx.doi.org/10.1085/jgp.200910234
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1113/jphysiol.2002.017301	http://dx.doi.org/10.1113/jphysiol.2002.017301
EMBL	AC017014	http://www.ebi.ac.uk/ena/data/view/AC017014
EMBL	AK294423	http://www.ebi.ac.uk/ena/data/view/AK294423
EMBL	AY065987	http://www.ebi.ac.uk/ena/data/view/AY065987
EMBL	BC014429	http://www.ebi.ac.uk/ena/data/view/BC014429
Ensembl	ENST00000281830	http://www.ensembl.org/id/ENST00000281830
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0044325	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044325
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GeneCards	KCNE4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNE4
GeneID	23704	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23704
GeneTree	ENSGT00390000013776	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000013776
HGNC	HGNC:6244	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6244
HOGENOM	HOG000237340	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237340&db=HOGENOM6
HOVERGEN	HBG052229	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052229&db=HOVERGEN
HPA	HPA011420	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA011420
InParanoid	Q8WWG9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8WWG9
IntAct	Q8WWG9	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8WWG9*
InterPro	IPR000369	http://www.ebi.ac.uk/interpro/entry/IPR000369
Jabion	23704	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=23704
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:23704	http://www.genome.jp/dbget-bin/www_bget?hsa:23704
KEGG_Orthology	KO:K04898	http://www.genome.jp/dbget-bin/www_bget?KO:K04898
MIM	607775	http://www.ncbi.nlm.nih.gov/omim/607775
OMA	LWGEAMK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LWGEAMK
OrthoDB	EOG091G0QZW	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0QZW
PRINTS	PR00168	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00168
PSORT	swissprot:KCNE4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNE4_HUMAN
PSORT-B	swissprot:KCNE4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNE4_HUMAN
PSORT2	swissprot:KCNE4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNE4_HUMAN
Pfam	PF02060	http://pfam.xfam.org/family/PF02060
PharmGKB	PA30032	http://www.pharmgkb.org/do/serve?objId=PA30032&objCls=Gene
Phobius	swissprot:KCNE4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNE4_HUMAN
ProteinModelPortal	Q8WWG9	http://www.proteinmodelportal.org/query/uniprot/Q8WWG9
PubMed	12096056	http://www.ncbi.nlm.nih.gov/pubmed/12096056
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	19687231	http://www.ncbi.nlm.nih.gov/pubmed/19687231
PubMed	20533308	http://www.ncbi.nlm.nih.gov/pubmed/20533308
Reactome	R-HSA-5576890	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576890
Reactome	R-HSA-5576893	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576893
RefSeq	NP_542402	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_542402
SMR	Q8WWG9	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8WWG9
STRING	9606.ENSP00000281830	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000281830&targetmode=cogs
UCSC	uc002vnl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002vnl&org=rat
UniGene	Hs.348522	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.348522
UniProtKB	KCNE4_HUMAN	http://www.uniprot.org/uniprot/KCNE4_HUMAN
UniProtKB-AC	Q8WWG9	http://www.uniprot.org/uniprot/Q8WWG9
charge	swissprot:KCNE4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNE4_HUMAN
eggNOG	ENOG410IWSX	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IWSX
eggNOG	ENOG41129VY	http://eggnogapi.embl.de/nog_data/html/tree/ENOG41129VY
epestfind	swissprot:KCNE4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNE4_HUMAN
garnier	swissprot:KCNE4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNE4_HUMAN
helixturnhelix	swissprot:KCNE4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNE4_HUMAN
hmoment	swissprot:KCNE4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNE4_HUMAN
iep	swissprot:KCNE4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNE4_HUMAN
inforesidue	swissprot:KCNE4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNE4_HUMAN
neXtProt	NX_Q8WWG9	http://www.nextprot.org/db/entry/NX_Q8WWG9
octanol	swissprot:KCNE4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNE4_HUMAN
pepcoil	swissprot:KCNE4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNE4_HUMAN
pepdigest	swissprot:KCNE4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNE4_HUMAN
pepinfo	swissprot:KCNE4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNE4_HUMAN
pepnet	swissprot:KCNE4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNE4_HUMAN
pepstats	swissprot:KCNE4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNE4_HUMAN
pepwheel	swissprot:KCNE4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNE4_HUMAN
pepwindow	swissprot:KCNE4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNE4_HUMAN
sigcleave	swissprot:KCNE4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNE4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AP2A2_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O94973-1; Sequence=Displayed; Name=2; IsoId=O94973-2; Sequence=VSP_035762; Note=No experimental confirmation available.; Name=3; IsoId=O94973-3; Sequence=VSP_035762, VSP_035763, VSP_035764; Note=No experimental confirmation available.; 
# AltName	AP2A2_HUMAN	100 kDa coated vesicle protein C
# AltName	AP2A2_HUMAN	Adaptor protein complex AP-2 subunit alpha-2
# AltName	AP2A2_HUMAN	Adaptor-related protein complex 2 subunit alpha-2
# AltName	AP2A2_HUMAN	Alpha-adaptin C
# AltName	AP2A2_HUMAN	Alpha2-adaptin
# AltName	AP2A2_HUMAN	Clathrin assembly protein complex 2 alpha-C large chain
# AltName	AP2A2_HUMAN	Huntingtin yeast partner J
# AltName	AP2A2_HUMAN	Huntingtin-interacting protein 9
# AltName	AP2A2_HUMAN	Huntingtin-interacting protein J
# AltName	AP2A2_HUMAN	Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit
# BioGrid	106670	66
# CCDS	CCDS44512	-. [O94973-1]
# CCDS	CCDS73234	-. [O94973-2]
# ChiTaRS	AP2A2	human
# Ensembl	ENST00000332231	ENSP00000327694; ENSG00000183020. [O94973-2]
# Ensembl	ENST00000448903	ENSP00000413234; ENSG00000183020. [O94973-1]
# Ensembl	ENST00000528815	ENSP00000431630; ENSG00000183020. [O94973-3]
# ExpressionAtlas	O94973	baseline and differential
# FUNCTION	AP2A2_HUMAN	Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C- terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). {ECO 0000250, ECO 0000269|PubMed 12960147, ECO 0000269|PubMed 14745134, ECO 0000269|PubMed 15473838, ECO 0000269|PubMed 19033387}. 
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016023	cytoplasmic, membrane-bounded vesicle; ISS:BHF-UCL.
# GO_component	GO:0030122	AP-2 adaptor complex; TAS:BHF-UCL.
# GO_component	GO:0030666	endocytic vesicle membrane; TAS:Reactome.
# GO_component	GO:0030669	clathrin-coated endocytic vesicle membrane; TAS:Reactome.
# GO_component	GO:0036020	endolysosome membrane; TAS:Reactome.
# GO_function	GO:0008289	lipid binding; IEA:UniProtKB-KW.
# GO_function	GO:0008565	protein transporter activity; IEA:InterPro.
# GO_function	GO:0019901	protein kinase binding; ISS:ParkinsonsUK-UCL.
# GO_process	GO:0006886	intracellular protein transport; IEA:InterPro.
# GO_process	GO:0007018	microtubule-based movement; TAS:Reactome.
# GO_process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
# GO_process	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0048013	ephrin receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0050690	regulation of defense response to virus by virus; TAS:Reactome.
# GO_process	GO:0060071	Wnt signaling pathway, planar cell polarity pathway; TAS:Reactome.
# GO_process	GO:0072583	clathrin-dependent endocytosis; TAS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0008289	lipid binding
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# Gene3D	1.25.10.10	-; 1.
# Gene3D	2.60.40.1030	-; 1.
# Gene3D	3.30.310.30	-; 1.
# Genevisible	O94973	HS
# HGNC	HGNC:562	AP2A2
# INTERACTION	AP2A2_HUMAN	P98078 Dab2 (xeno); NbExp=2; IntAct=EBI-1642835, EBI-1391846; Q61743 Kcnj11 (xeno); NbExp=2; IntAct=EBI-1642835, EBI-8603527; 
# IntAct	O94973	33
# InterPro	IPR002553	Clathrin/coatomer_adapt-like_N
# InterPro	IPR003164	Clathrin_a-adaptin_app_sub_C
# InterPro	IPR008152	Clathrin_a/b/g-adaptin_app_Ig
# InterPro	IPR009028	Coatomer/calthrin_app_sub_C
# InterPro	IPR011989	ARM-like
# InterPro	IPR013038	Clathrin_a-adaptin_app_Ig-like
# InterPro	IPR013041	Coatomer/clathrin_app_Ig-like
# InterPro	IPR015873	Clathrin_a/coatomer_app_sub_C
# InterPro	IPR016024	ARM-type_fold
# InterPro	IPR017104	AP2_complex_asu
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Pathway	ko04144	Endocytosis
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04961	Endocrine and other factor-regulated calcium reabsorption
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	607242	gene
# Organism	AP2A2_HUMAN	Homo sapiens (Human)
# PIRSF	PIRSF037091	AP2_complex_alpha
# Pfam	PF01602	Adaptin_N
# Pfam	PF02296	Alpha_adaptin_C
# Pfam	PF02883	Alpha_adaptinC2
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-167590	Nef Mediated CD4 Down-regulation
# Reactome	R-HSA-171052	LDL-mediated lipid transport
# Reactome	R-HSA-177504	Retrograde neurotrophin signalling
# Reactome	R-HSA-182218	Nef Mediated CD8 Down-regulation
# Reactome	R-HSA-2132295	MHC class II antigen presentation
# Reactome	R-HSA-3928665	EPH-ephrin mediated repulsion of cells
# Reactome	R-HSA-416993	Trafficking of GluR2-containing AMPA receptors
# Reactome	R-HSA-437239	Recycling pathway of L1
# Reactome	R-HSA-5099900	WNT5A-dependent internalization of FZD4
# Reactome	R-HSA-5140745	WNT5A-dependent internalization of FZD2, FZD5 and ROR2
# Reactome	R-HSA-6798695	Neutrophil degranulation
# Reactome	R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis
# Reactome	R-HSA-8856828	Clathrin-mediated endocytosis
# Reactome	R-HSA-8866427	VLDLR internalisation and degradation
# RecName	AP2A2_HUMAN	AP-2 complex subunit alpha-2
# RefSeq	NP_001229766	NM_001242837.1. [O94973-2]
# RefSeq	NP_036437	NM_012305.3. [O94973-1]
# SIMILARITY	Belongs to the adaptor complexes large subunit family. {ECO	0000305}.
# SMART	SM00809	Alpha_adaptinC2
# SUBCELLULAR LOCATION	AP2A2_HUMAN	Cell membrane {ECO 0000250|UniProtKB P17427}; Peripheral membrane protein {ECO 0000250|UniProtKB P17427}; Cytoplasmic side {ECO 0000250|UniProtKB P17427}. Membrane, coated pit {ECO 0000250|UniProtKB P17427}; Peripheral membrane protein {ECO 0000250|UniProtKB P17427}; Cytoplasmic side {ECO 0000250|UniProtKB P17427}. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. {ECO 0000250|UniProtKB P17427}. 
# SUBUNIT	AP2A2_HUMAN	Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1). Binds EPN1, EPS15, AMPH, SNAP91 and BIN1. Interacts with HIP1. Interacts with DGKD isoform 2 (By similarity). Interacts with DENND1A, DENND1B and DENND1C (By similarity). Interacts with FCHO1 and DAB2. Interacts with ATAT1; this interaction is required for efficient alpha-tubulin acetylation by ATAT1. {ECO 0000250, ECO 0000269|PubMed 11532990, ECO 0000269|PubMed 22484487, ECO 0000269|PubMed 24097348}. 
# SUPFAM	SSF48371	SSF48371
# SUPFAM	SSF49348	SSF49348
# SUPFAM	SSF55711	SSF55711
# UCSC	uc001lss	human. [O94973-1]
# eggNOG	ENOG410XNQE	LUCA
# eggNOG	KOG1077	Eukaryota
BLAST	swissprot:AP2A2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AP2A2_HUMAN
BioCyc	ZFISH:G66-33391-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33391-MONOMER
COXPRESdb	161	http://coxpresdb.jp/data/gene/161.shtml
CleanEx	HS_AP2A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AP2A2
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature12571	http://dx.doi.org/10.1038/nature12571
DOI	10.1038/ncb2473	http://dx.doi.org/10.1038/ncb2473
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M307290200	http://dx.doi.org/10.1074/jbc.M307290200
DOI	10.1093/dnares/5.6.355	http://dx.doi.org/10.1093/dnares/5.6.355
DOI	10.1093/dnares/9.3.99	http://dx.doi.org/10.1093/dnares/9.3.99
DOI	10.1093/hmg/10.17.1807	http://dx.doi.org/10.1093/hmg/10.17.1807
DOI	10.1093/hmg/7.9.1463	http://dx.doi.org/10.1093/hmg/7.9.1463
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1146/annurev.cellbio.20.010403.104543	http://dx.doi.org/10.1146/annurev.cellbio.20.010403.104543
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1242/jcs.033522	http://dx.doi.org/10.1242/jcs.033522
DOI	10.1247/csf.28.419	http://dx.doi.org/10.1247/csf.28.419
EMBL	AB020706	http://www.ebi.ac.uk/ena/data/view/AB020706
EMBL	AF049527	http://www.ebi.ac.uk/ena/data/view/AF049527
EMBL	AK027891	http://www.ebi.ac.uk/ena/data/view/AK027891
EMBL	AK223558	http://www.ebi.ac.uk/ena/data/view/AK223558
EMBL	BC006155	http://www.ebi.ac.uk/ena/data/view/BC006155
Ensembl	ENST00000332231	http://www.ensembl.org/id/ENST00000332231
Ensembl	ENST00000448903	http://www.ensembl.org/id/ENST00000448903
Ensembl	ENST00000528815	http://www.ensembl.org/id/ENST00000528815
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016023	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016023
GO_component	GO:0030122	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030122
GO_component	GO:0030666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030666
GO_component	GO:0030669	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030669
GO_component	GO:0036020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036020
GO_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0019901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019901
GO_process	GO:0006886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006886
GO_process	GO:0007018	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007018
GO_process	GO:0019886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019886
GO_process	GO:0042059	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042059
GO_process	GO:0048013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048013
GO_process	GO:0050690	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050690
GO_process	GO:0060071	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060071
GO_process	GO:0072583	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072583
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
Gene3D	2.60.40.1030	http://www.cathdb.info/version/latest/superfamily/2.60.40.1030
Gene3D	3.30.310.30	http://www.cathdb.info/version/latest/superfamily/3.30.310.30
GeneCards	AP2A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=AP2A2
GeneID	161	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=161
GeneTree	ENSGT00550000074757	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074757
HGNC	HGNC:562	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:562
HOGENOM	HOG000170596	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000170596&db=HOGENOM6
HOVERGEN	HBG050518	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050518&db=HOVERGEN
HPA	CAB017514	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB017514
HPA	HPA043040	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA043040
InParanoid	O94973	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O94973
IntAct	O94973	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O94973*
InterPro	IPR002553	http://www.ebi.ac.uk/interpro/entry/IPR002553
InterPro	IPR003164	http://www.ebi.ac.uk/interpro/entry/IPR003164
InterPro	IPR008152	http://www.ebi.ac.uk/interpro/entry/IPR008152
InterPro	IPR009028	http://www.ebi.ac.uk/interpro/entry/IPR009028
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR013038	http://www.ebi.ac.uk/interpro/entry/IPR013038
InterPro	IPR013041	http://www.ebi.ac.uk/interpro/entry/IPR013041
InterPro	IPR015873	http://www.ebi.ac.uk/interpro/entry/IPR015873
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
InterPro	IPR017104	http://www.ebi.ac.uk/interpro/entry/IPR017104
Jabion	161	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=161
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Gene	hsa:161	http://www.genome.jp/dbget-bin/www_bget?hsa:161
KEGG_Orthology	KO:K11824	http://www.genome.jp/dbget-bin/www_bget?KO:K11824
KEGG_Pathway	ko04144	http://www.genome.jp/kegg-bin/show_pathway?ko04144
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04961	http://www.genome.jp/kegg-bin/show_pathway?ko04961
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	607242	http://www.ncbi.nlm.nih.gov/omim/607242
MINT	MINT-1198502	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1198502
OMA	QMINAEC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QMINAEC
OrthoDB	EOG091G01JZ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01JZ
PSORT	swissprot:AP2A2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AP2A2_HUMAN
PSORT-B	swissprot:AP2A2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AP2A2_HUMAN
PSORT2	swissprot:AP2A2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AP2A2_HUMAN
Pfam	PF01602	http://pfam.xfam.org/family/PF01602
Pfam	PF02296	http://pfam.xfam.org/family/PF02296
Pfam	PF02883	http://pfam.xfam.org/family/PF02883
PharmGKB	PA24853	http://www.pharmgkb.org/do/serve?objId=PA24853&objCls=Gene
Phobius	swissprot:AP2A2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AP2A2_HUMAN
PhylomeDB	O94973	http://phylomedb.org/?seqid=O94973
ProteinModelPortal	O94973	http://www.proteinmodelportal.org/query/uniprot/O94973
PubMed	10048485	http://www.ncbi.nlm.nih.gov/pubmed/10048485
PubMed	11532990	http://www.ncbi.nlm.nih.gov/pubmed/11532990
PubMed	12168954	http://www.ncbi.nlm.nih.gov/pubmed/12168954
PubMed	12960147	http://www.ncbi.nlm.nih.gov/pubmed/12960147
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	14745134	http://www.ncbi.nlm.nih.gov/pubmed/14745134
PubMed	15473838	http://www.ncbi.nlm.nih.gov/pubmed/15473838
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19033387	http://www.ncbi.nlm.nih.gov/pubmed/19033387
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22484487	http://www.ncbi.nlm.nih.gov/pubmed/22484487
PubMed	24097348	http://www.ncbi.nlm.nih.gov/pubmed/24097348
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	9700202	http://www.ncbi.nlm.nih.gov/pubmed/9700202
Reactome	R-HSA-167590	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-167590
Reactome	R-HSA-171052	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-171052
Reactome	R-HSA-177504	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-177504
Reactome	R-HSA-182218	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-182218
Reactome	R-HSA-2132295	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2132295
Reactome	R-HSA-3928665	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3928665
Reactome	R-HSA-416993	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-416993
Reactome	R-HSA-437239	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-437239
Reactome	R-HSA-5099900	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5099900
Reactome	R-HSA-5140745	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5140745
Reactome	R-HSA-6798695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6798695
Reactome	R-HSA-8856825	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8856825
Reactome	R-HSA-8856828	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8856828
Reactome	R-HSA-8866427	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8866427
RefSeq	NP_001229766	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001229766
RefSeq	NP_036437	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_036437
SMART	SM00809	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00809
SMR	O94973	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O94973
STRING	9606.ENSP00000413234	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000413234&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
SUPFAM	SSF49348	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49348
SUPFAM	SSF55711	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55711
UCSC	uc001lss	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001lss&org=rat
UniGene	Hs.19121	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.19121
UniProtKB	AP2A2_HUMAN	http://www.uniprot.org/uniprot/AP2A2_HUMAN
UniProtKB-AC	O94973	http://www.uniprot.org/uniprot/O94973
charge	swissprot:AP2A2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AP2A2_HUMAN
eggNOG	ENOG410XNQE	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNQE
eggNOG	KOG1077	http://eggnogapi.embl.de/nog_data/html/tree/KOG1077
epestfind	swissprot:AP2A2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AP2A2_HUMAN
garnier	swissprot:AP2A2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AP2A2_HUMAN
helixturnhelix	swissprot:AP2A2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AP2A2_HUMAN
hmoment	swissprot:AP2A2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AP2A2_HUMAN
iep	swissprot:AP2A2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AP2A2_HUMAN
inforesidue	swissprot:AP2A2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AP2A2_HUMAN
neXtProt	NX_O94973	http://www.nextprot.org/db/entry/NX_O94973
octanol	swissprot:AP2A2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AP2A2_HUMAN
pepcoil	swissprot:AP2A2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AP2A2_HUMAN
pepdigest	swissprot:AP2A2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AP2A2_HUMAN
pepinfo	swissprot:AP2A2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AP2A2_HUMAN
pepnet	swissprot:AP2A2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AP2A2_HUMAN
pepstats	swissprot:AP2A2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AP2A2_HUMAN
pepwheel	swissprot:AP2A2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AP2A2_HUMAN
pepwindow	swissprot:AP2A2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AP2A2_HUMAN
sigcleave	swissprot:AP2A2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AP2A2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNG1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UIX4-1; Sequence=Displayed; Name=2; IsoId=Q9UIX4-2; Sequence=VSP_001024, VSP_001025; Note=No experimental confirmation available.; 
# AltName	KCNG1_HUMAN	Voltage-gated potassium channel subunit Kv6.1
# AltName	KCNG1_HUMAN	kH2
# BioGrid	109957	4
# CCDS	CCDS13436	-. [Q9UIX4-1]
# ChiTaRS	KCNG1	human
# DOMAIN	KCNG1_HUMAN	The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. {ECO 0000250|UniProtKB P63142}. 
# Ensembl	ENST00000371571	ENSP00000360626; ENSG00000026559. [Q9UIX4-1]
# ExpressionAtlas	Q9UIX4	baseline and differential
# FUNCTION	KCNG1_HUMAN	Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed 19074135). {ECO 0000269|PubMed 19074135}. 
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IEA:Ensembl.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; IDA:UniProtKB.
# GO_function	GO:0005267	potassium channel activity; NAS:UniProtKB.
# GO_process	GO:0006813	potassium ion transport; NAS:UniProtKB.
# GO_process	GO:0051260	protein homooligomerization; IEA:InterPro.
# GO_process	GO:0071805	potassium ion transmembrane transport; IDA:UniProtKB.
# GO_process	GO:1902259	regulation of delayed rectifier potassium channel activity; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.350	-; 1.
# Genevisible	Q9UIX4	HS
# HGNC	HGNC:6248	KCNG1
# InterPro	IPR000210	BTB/POZ_dom
# InterPro	IPR003131	T1-type_BTB
# InterPro	IPR003968	K_chnl_volt-dep_Kv
# InterPro	IPR003969	K_chnl_volt-dep_Kv6
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR011333	SKP1/BTB/POZ
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko04040	Ion channels
# MIM	603788	gene
# Organism	KCNG1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11537	PTHR11537
# PIR	JC5920	JC5920
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01491	KVCHANNEL
# PRINTS	PR01492	KV6CHANNEL
# Pfam	PF00520	Ion_trans
# Pfam	PF02214	BTB_2
# Proteomes	UP000005640	Chromosome 20
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# RecName	KCNG1_HUMAN	Potassium voltage-gated channel subfamily G member 1
# RefSeq	NP_002228	NM_002237.3. [Q9UIX4-1]
# RefSeq	XP_006723848	XM_006723785.2. [Q9UIX4-1]
# RefSeq	XP_011527102	XM_011528800.1. [Q9UIX4-1]
# RefSeq	XP_011527103	XM_011528801.1. [Q9UIX4-1]
# RefSeq	XP_011527104	XM_011528802.1. [Q9UIX4-1]
# RefSeq	XP_011527105	XM_011528803.2. [Q9UIX4-1]
# RefSeq	XP_011527106	XM_011528804.1. [Q9UIX4-1]
# RefSeq	XP_011527107	XM_011528805.2. [Q9UIX4-1]
# RefSeq	XP_011527108	XM_011528806.1. [Q9UIX4-1]
# SIMILARITY	Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.1/KCNG1 sub-subfamily. {ECO	0000305}.
# SMART	SM00225	BTB
# SUBCELLULAR LOCATION	KCNG1_HUMAN	Cell membrane {ECO 0000269|PubMed 19074135}; Multi-pass membrane protein {ECO 0000305}. Note=Colocalizes with KCNB1 at the plasma membrane (PubMed 19074135). {ECO 0000269|PubMed 19074135}. 
# SUBUNIT	Heterotetramer with KCNB1 (PubMed:19074135). {ECO	0000269|PubMed:19074135}. 
# SUPFAM	SSF54695	SSF54695
# TISSUE SPECIFICITY	Expressed in brain and placenta, and at much lower levels in kidney and pancreas (PubMed:9434767). {ECO	0000269|PubMed:9434767}. 
# UCSC	uc002xwa	human. [Q9UIX4-1]
# eggNOG	COG1226	LUCA
# eggNOG	KOG3713	Eukaryota
BLAST	swissprot:KCNG1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNG1_HUMAN
BioCyc	ZFISH:ENSG00000026559-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000026559-MONOMER
COXPRESdb	3755	http://coxpresdb.jp/data/gene/3755.shtml
CleanEx	HS_KCNG1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNG1
DOI	10.1006/bbrc.1997.7830	http://dx.doi.org/10.1006/bbrc.1997.7830
DOI	10.1038/414865a	http://dx.doi.org/10.1038/414865a
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M808786200	http://dx.doi.org/10.1074/jbc.M808786200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF033383	http://www.ebi.ac.uk/ena/data/view/AF033383
EMBL	AK290689	http://www.ebi.ac.uk/ena/data/view/AK290689
EMBL	AL050404	http://www.ebi.ac.uk/ena/data/view/AL050404
EMBL	AL050404	http://www.ebi.ac.uk/ena/data/view/AL050404
EMBL	AL121785	http://www.ebi.ac.uk/ena/data/view/AL121785
EMBL	BC006367	http://www.ebi.ac.uk/ena/data/view/BC006367
EMBL	CH471077	http://www.ebi.ac.uk/ena/data/view/CH471077
Ensembl	ENST00000371571	http://www.ensembl.org/id/ENST00000371571
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GO_process	GO:1902259	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902259
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	KCNG1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNG1
GeneID	3755	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3755
GeneTree	ENSGT00760000118981	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118981
H-InvDB	HIX0015916	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0015916
HGNC	HGNC:6248	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6248
HOGENOM	HOG000231014	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231014&db=HOGENOM6
HOVERGEN	HBG100172	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG100172&db=HOVERGEN
HPA	HPA039530	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA039530
HPA	HPA040024	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA040024
InParanoid	Q9UIX4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UIX4
IntAct	Q9UIX4	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9UIX4*
InterPro	IPR000210	http://www.ebi.ac.uk/interpro/entry/IPR000210
InterPro	IPR003131	http://www.ebi.ac.uk/interpro/entry/IPR003131
InterPro	IPR003968	http://www.ebi.ac.uk/interpro/entry/IPR003968
InterPro	IPR003969	http://www.ebi.ac.uk/interpro/entry/IPR003969
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR011333	http://www.ebi.ac.uk/interpro/entry/IPR011333
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	3755	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3755
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3755	http://www.genome.jp/dbget-bin/www_bget?hsa:3755
KEGG_Orthology	KO:K04900	http://www.genome.jp/dbget-bin/www_bget?KO:K04900
MIM	603788	http://www.ncbi.nlm.nih.gov/omim/603788
OMA	GQCSQMC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GQCSQMC
OrthoDB	EOG091G05DD	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05DD
PANTHER	PTHR11537	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01491	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01491
PRINTS	PR01492	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01492
PSORT	swissprot:KCNG1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNG1_HUMAN
PSORT-B	swissprot:KCNG1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNG1_HUMAN
PSORT2	swissprot:KCNG1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNG1_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF02214	http://pfam.xfam.org/family/PF02214
PharmGKB	PA30034	http://www.pharmgkb.org/do/serve?objId=PA30034&objCls=Gene
Phobius	swissprot:KCNG1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNG1_HUMAN
PhylomeDB	Q9UIX4	http://phylomedb.org/?seqid=Q9UIX4
ProteinModelPortal	Q9UIX4	http://www.proteinmodelportal.org/query/uniprot/Q9UIX4
PubMed	11780052	http://www.ncbi.nlm.nih.gov/pubmed/11780052
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19074135	http://www.ncbi.nlm.nih.gov/pubmed/19074135
PubMed	9434767	http://www.ncbi.nlm.nih.gov/pubmed/9434767
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
RefSeq	NP_002228	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002228
RefSeq	XP_006723848	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006723848
RefSeq	XP_011527102	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011527102
RefSeq	XP_011527103	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011527103
RefSeq	XP_011527104	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011527104
RefSeq	XP_011527105	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011527105
RefSeq	XP_011527106	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011527106
RefSeq	XP_011527107	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011527107
RefSeq	XP_011527108	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011527108
SMART	SM00225	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225
STRING	9606.ENSP00000360626	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000360626&targetmode=cogs
SUPFAM	SSF54695	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54695
UCSC	uc002xwa	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002xwa&org=rat
UniGene	Hs.118695	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.118695
UniGene	Hs.735151	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.735151
UniProtKB	KCNG1_HUMAN	http://www.uniprot.org/uniprot/KCNG1_HUMAN
UniProtKB-AC	Q9UIX4	http://www.uniprot.org/uniprot/Q9UIX4
charge	swissprot:KCNG1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNG1_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG3713	http://eggnogapi.embl.de/nog_data/html/tree/KOG3713
epestfind	swissprot:KCNG1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNG1_HUMAN
garnier	swissprot:KCNG1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNG1_HUMAN
helixturnhelix	swissprot:KCNG1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNG1_HUMAN
hmoment	swissprot:KCNG1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNG1_HUMAN
iep	swissprot:KCNG1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNG1_HUMAN
inforesidue	swissprot:KCNG1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNG1_HUMAN
neXtProt	NX_Q9UIX4	http://www.nextprot.org/db/entry/NX_Q9UIX4
octanol	swissprot:KCNG1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNG1_HUMAN
pepcoil	swissprot:KCNG1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNG1_HUMAN
pepdigest	swissprot:KCNG1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNG1_HUMAN
pepinfo	swissprot:KCNG1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNG1_HUMAN
pepnet	swissprot:KCNG1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNG1_HUMAN
pepstats	swissprot:KCNG1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNG1_HUMAN
pepwheel	swissprot:KCNG1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNG1_HUMAN
pepwindow	swissprot:KCNG1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNG1_HUMAN
sigcleave	swissprot:KCNG1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNG1_HUMAN
## Database	ID	URL or Descriptions
# AltName	S15A1_HUMAN	Intestinal H(+)/peptide cotransporter
# AltName	S15A1_HUMAN	Oligopeptide transporter, small intestine isoform
# AltName	S15A1_HUMAN	Peptide transporter 1
# BioGrid	112452	64
# CDD	cd06174	MFS
# DrugBank	DB00178	Ramipril
# DrugBank	DB00198	Oseltamivir
# DrugBank	DB00211	Midodrine
# DrugBank	DB00274	Cefmetazole
# DrugBank	DB00415	Ampicillin
# DrugBank	DB00417	Phenoxymethylpenicillin
# DrugBank	DB00438	Ceftazidime
# DrugBank	DB00456	Cefalotin
# DrugBank	DB00485	Dicloxacillin
# DrugBank	DB00492	Fosinopril
# DrugBank	DB00493	Cefotaxime
# DrugBank	DB00519	Trandolapril
# DrugBank	DB00535	Cefdinir
# DrugBank	DB00542	Benazepril
# DrugBank	DB00567	Cephalexin
# DrugBank	DB00577	Valaciclovir
# DrugBank	DB00584	Enalapril
# DrugBank	DB00671	Cefixime
# DrugBank	DB00672	Chlorpropamide
# DrugBank	DB00691	Moexipril
# DrugBank	DB00713	Oxacillin
# DrugBank	DB00722	Lisinopril
# DrugBank	DB00731	Nateglinide
# DrugBank	DB00790	Perindopril
# DrugBank	DB00833	Cefaclor
# DrugBank	DB00855	Aminolevulinic acid
# DrugBank	DB00881	Quinapril
# DrugBank	DB00968	Methyldopa
# DrugBank	DB01000	Cyclacillin
# DrugBank	DB01016	Glyburide
# DrugBank	DB01053	Benzylpenicillin
# DrugBank	DB01060	Amoxicillin
# DrugBank	DB01095	Fluvastatin
# DrugBank	DB01112	Cefuroxime
# DrugBank	DB01124	Tolbutamide
# DrugBank	DB01140	Cefadroxil
# DrugBank	DB01147	Cloxacillin
# DrugBank	DB01197	Captopril
# DrugBank	DB01212	Ceftriaxone
# DrugBank	DB01235	Levodopa
# DrugBank	DB01332	Ceftizoxime
# DrugBank	DB01333	Cefradine
# DrugBank	DB01340	Cilazapril
# DrugBank	DB01348	Spirapril
# DrugBank	DB01413	Cefepime
# DrugBank	DB01415	Ceftibuten
# DrugBank	DB01610	Valganciclovir
# DrugBank	DB08795	Azidocillin
# Ensembl	ENST00000376503	ENSP00000365686; ENSG00000088386
# ExpressionAtlas	P46059	baseline and differential
# FUNCTION	S15A1_HUMAN	Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0005903	brush border; IEA:Ensembl.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_function	GO:0005427	proton-dependent oligopeptide secondary active transmembrane transporter activity; IEA:Ensembl.
# GO_function	S15A1_HUMAN	GO 0015333 peptide proton symporter activity; TAS Reactome.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0007586	digestion; TAS:ProtInc.
# GO_process	GO:0015031	protein transport; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Genevisible	P46059	HS
# HGNC	HGNC:10920	SLC15A1
# InterPro	IPR000109	POT_fam
# InterPro	IPR004768	Oligopep_transport
# InterPro	IPR018456	PTR2_symporter_CS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04974	Protein digestion and absorption
# MIM	600544	gene
# Organism	S15A1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11654	PTHR11654; 2
# PIR	A56163	A56163
# PROSITE	PS01022	PTR2_1
# PROSITE	PS01023	PTR2_2
# Pfam	PF00854	PTR2; 2
# Proteomes	UP000005640	Chromosome 13
# Reactome	R-HSA-427975	Proton/oligopeptide cotransporters
# RecName	S15A1_HUMAN	Solute carrier family 15 member 1
# RefSeq	NP_005064	NM_005073.3
# SIMILARITY	Belongs to the PTR2/POT transporter (TC 2.A.17) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S15A1_HUMAN	Membrane; Multi-pass membrane protein. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.17.4	the proton-dependent oligopeptide transporter (pot/ptr) family
# TIGRFAMs	TIGR00926	2A1704
# UCSC	uc001vno	human
# eggNOG	COG3104	LUCA
# eggNOG	KOG1237	Eukaryota
BLAST	swissprot:S15A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S15A1_HUMAN
BioCyc	ZFISH:ENSG00000088386-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000088386-MONOMER
COXPRESdb	6564	http://coxpresdb.jp/data/gene/6564.shtml
CleanEx	HS_SLC15A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC15A1
DOI	10.1007/s100380200088	http://dx.doi.org/10.1007/s100380200088
DOI	10.1038/nature02379	http://dx.doi.org/10.1038/nature02379
DOI	10.1074/jbc.270.12.6456	http://dx.doi.org/10.1074/jbc.270.12.6456
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1124/jpet.105.094615	http://dx.doi.org/10.1124/jpet.105.094615
DrugBank	DB00178	http://www.drugbank.ca/drugs/DB00178
DrugBank	DB00198	http://www.drugbank.ca/drugs/DB00198
DrugBank	DB00211	http://www.drugbank.ca/drugs/DB00211
DrugBank	DB00274	http://www.drugbank.ca/drugs/DB00274
DrugBank	DB00415	http://www.drugbank.ca/drugs/DB00415
DrugBank	DB00417	http://www.drugbank.ca/drugs/DB00417
DrugBank	DB00438	http://www.drugbank.ca/drugs/DB00438
DrugBank	DB00456	http://www.drugbank.ca/drugs/DB00456
DrugBank	DB00485	http://www.drugbank.ca/drugs/DB00485
DrugBank	DB00492	http://www.drugbank.ca/drugs/DB00492
DrugBank	DB00493	http://www.drugbank.ca/drugs/DB00493
DrugBank	DB00519	http://www.drugbank.ca/drugs/DB00519
DrugBank	DB00535	http://www.drugbank.ca/drugs/DB00535
DrugBank	DB00542	http://www.drugbank.ca/drugs/DB00542
DrugBank	DB00567	http://www.drugbank.ca/drugs/DB00567
DrugBank	DB00577	http://www.drugbank.ca/drugs/DB00577
DrugBank	DB00584	http://www.drugbank.ca/drugs/DB00584
DrugBank	DB00671	http://www.drugbank.ca/drugs/DB00671
DrugBank	DB00672	http://www.drugbank.ca/drugs/DB00672
DrugBank	DB00691	http://www.drugbank.ca/drugs/DB00691
DrugBank	DB00713	http://www.drugbank.ca/drugs/DB00713
DrugBank	DB00722	http://www.drugbank.ca/drugs/DB00722
DrugBank	DB00731	http://www.drugbank.ca/drugs/DB00731
DrugBank	DB00790	http://www.drugbank.ca/drugs/DB00790
DrugBank	DB00833	http://www.drugbank.ca/drugs/DB00833
DrugBank	DB00855	http://www.drugbank.ca/drugs/DB00855
DrugBank	DB00881	http://www.drugbank.ca/drugs/DB00881
DrugBank	DB00968	http://www.drugbank.ca/drugs/DB00968
DrugBank	DB01000	http://www.drugbank.ca/drugs/DB01000
DrugBank	DB01016	http://www.drugbank.ca/drugs/DB01016
DrugBank	DB01053	http://www.drugbank.ca/drugs/DB01053
DrugBank	DB01060	http://www.drugbank.ca/drugs/DB01060
DrugBank	DB01095	http://www.drugbank.ca/drugs/DB01095
DrugBank	DB01112	http://www.drugbank.ca/drugs/DB01112
DrugBank	DB01124	http://www.drugbank.ca/drugs/DB01124
DrugBank	DB01140	http://www.drugbank.ca/drugs/DB01140
DrugBank	DB01147	http://www.drugbank.ca/drugs/DB01147
DrugBank	DB01197	http://www.drugbank.ca/drugs/DB01197
DrugBank	DB01212	http://www.drugbank.ca/drugs/DB01212
DrugBank	DB01235	http://www.drugbank.ca/drugs/DB01235
DrugBank	DB01332	http://www.drugbank.ca/drugs/DB01332
DrugBank	DB01333	http://www.drugbank.ca/drugs/DB01333
DrugBank	DB01340	http://www.drugbank.ca/drugs/DB01340
DrugBank	DB01348	http://www.drugbank.ca/drugs/DB01348
DrugBank	DB01413	http://www.drugbank.ca/drugs/DB01413
DrugBank	DB01415	http://www.drugbank.ca/drugs/DB01415
DrugBank	DB01610	http://www.drugbank.ca/drugs/DB01610
DrugBank	DB08795	http://www.drugbank.ca/drugs/DB08795
EMBL	AL353574	http://www.ebi.ac.uk/ena/data/view/AL353574
EMBL	AL353574	http://www.ebi.ac.uk/ena/data/view/AL353574
EMBL	AL391670	http://www.ebi.ac.uk/ena/data/view/AL391670
EMBL	AL391670	http://www.ebi.ac.uk/ena/data/view/AL391670
EMBL	BC096328	http://www.ebi.ac.uk/ena/data/view/BC096328
EMBL	BC096329	http://www.ebi.ac.uk/ena/data/view/BC096329
EMBL	U13173	http://www.ebi.ac.uk/ena/data/view/U13173
EMBL	U21936	http://www.ebi.ac.uk/ena/data/view/U21936
Ensembl	ENST00000376503	http://www.ensembl.org/id/ENST00000376503
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005903	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005903
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0005427	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005427
GO_function	GO:0015333	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015333
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0007586	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007586
GO_process	GO:0015031	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	SLC15A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC15A1
GeneID	6564	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6564
GeneTree	ENSGT00530000062961	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062961
HGNC	HGNC:10920	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10920
HOGENOM	HOG000285186	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000285186&db=HOGENOM6
HOVERGEN	HBG052962	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052962&db=HOVERGEN
HPA	HPA002827	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA002827
InParanoid	P46059	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46059
InterPro	IPR000109	http://www.ebi.ac.uk/interpro/entry/IPR000109
InterPro	IPR004768	http://www.ebi.ac.uk/interpro/entry/IPR004768
InterPro	IPR018456	http://www.ebi.ac.uk/interpro/entry/IPR018456
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	6564	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6564
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6564	http://www.genome.jp/dbget-bin/www_bget?hsa:6564
KEGG_Orthology	KO:K14206	http://www.genome.jp/dbget-bin/www_bget?KO:K14206
KEGG_Pathway	ko04974	http://www.genome.jp/kegg-bin/show_pathway?ko04974
MIM	600544	http://www.ncbi.nlm.nih.gov/omim/600544
OMA	AYTYVIR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AYTYVIR
OrthoDB	EOG091G0M1S	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0M1S
PANTHER	PTHR11654	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11654
PROSITE	PS01022	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01022
PROSITE	PS01023	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01023
PSORT	swissprot:S15A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S15A1_HUMAN
PSORT-B	swissprot:S15A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S15A1_HUMAN
PSORT2	swissprot:S15A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S15A1_HUMAN
Pfam	PF00854	http://pfam.xfam.org/family/PF00854
PharmGKB	PA323	http://www.pharmgkb.org/do/serve?objId=PA323&objCls=Gene
Phobius	swissprot:S15A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S15A1_HUMAN
PhylomeDB	P46059	http://phylomedb.org/?seqid=P46059
ProteinModelPortal	P46059	http://www.proteinmodelportal.org/query/uniprot/P46059
PubMed	12436193	http://www.ncbi.nlm.nih.gov/pubmed/12436193
PubMed	15057823	http://www.ncbi.nlm.nih.gov/pubmed/15057823
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16258023	http://www.ncbi.nlm.nih.gov/pubmed/16258023
PubMed	7896779	http://www.ncbi.nlm.nih.gov/pubmed/7896779
Reactome	R-HSA-427975	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-427975
RefSeq	NP_005064	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005064
SMR	P46059	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P46059
STRING	9606.ENSP00000365686	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000365686&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.17.4	http://www.tcdb.org/search/result.php?tc=2.A.17.4
TIGRFAMs	TIGR00926	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00926
UCSC	uc001vno	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001vno&org=rat
UniGene	Hs.436893	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.436893
UniProtKB	S15A1_HUMAN	http://www.uniprot.org/uniprot/S15A1_HUMAN
UniProtKB-AC	P46059	http://www.uniprot.org/uniprot/P46059
charge	swissprot:S15A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S15A1_HUMAN
eggNOG	COG3104	http://eggnogapi.embl.de/nog_data/html/tree/COG3104
eggNOG	KOG1237	http://eggnogapi.embl.de/nog_data/html/tree/KOG1237
epestfind	swissprot:S15A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S15A1_HUMAN
garnier	swissprot:S15A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S15A1_HUMAN
helixturnhelix	swissprot:S15A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S15A1_HUMAN
hmoment	swissprot:S15A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S15A1_HUMAN
iep	swissprot:S15A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S15A1_HUMAN
inforesidue	swissprot:S15A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S15A1_HUMAN
neXtProt	NX_P46059	http://www.nextprot.org/db/entry/NX_P46059
octanol	swissprot:S15A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S15A1_HUMAN
pepcoil	swissprot:S15A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S15A1_HUMAN
pepdigest	swissprot:S15A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S15A1_HUMAN
pepinfo	swissprot:S15A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S15A1_HUMAN
pepnet	swissprot:S15A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S15A1_HUMAN
pepstats	swissprot:S15A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S15A1_HUMAN
pepwheel	swissprot:S15A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S15A1_HUMAN
pepwindow	swissprot:S15A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S15A1_HUMAN
sigcleave	swissprot:S15A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S15A1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNKA_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=A; Synonyms=TREK-2a; IsoId=P57789-1; Sequence=Displayed; Name=B; Synonyms=TREK-2b; IsoId=P57789-4; Sequence=VSP_006697; Name=C; Synonyms=TREK-2c; IsoId=P57789-3; Sequence=VSP_006698; 
# AltName	KCNKA_HUMAN	Outward rectifying potassium channel protein TREK-2
# AltName	KCNKA_HUMAN	TREK-2 K(+) channel subunit
# CCDS	CCDS9880	-. [P57789-1]
# CCDS	CCDS9881	-. [P57789-3]
# CCDS	CCDS9882	-. [P57789-4]
# ChiTaRS	KCNK10	human
# Ensembl	ENST00000312350	ENSP00000310568; ENSG00000100433. [P57789-4]
# Ensembl	ENST00000319231	ENSP00000312811; ENSG00000100433. [P57789-3]
# Ensembl	ENST00000340700	ENSP00000343104; ENSG00000100433. [P57789-1]
# ExpressionAtlas	P57789	baseline and differential
# FUNCTION	KCNKA_HUMAN	Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0005244	voltage-gated ion channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0005267	potassium channel activity; TAS:ProtInc.
# GO_function	GO:0022841	potassium ion leak channel activity; IBA:GO_Central.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007165	signal transduction; NAS:ProtInc.
# GO_process	GO:0007613	memory; IEA:Ensembl.
# GO_process	GO:0030322	stabilization of membrane potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# Genevisible	P57789	HS
# HGNC	HGNC:6273	KCNK10
# IntAct	P57789	2
# InterPro	IPR003280	2pore_dom_K_chnl
# InterPro	IPR003976	2pore_dom_K_chnl_TREK
# InterPro	IPR013099	K_chnl_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04971	Gastric acid secretion
# MIM	605873	gene
# Organism	KCNKA_HUMAN	Homo sapiens (Human)
# PDB	4BW5	X-ray; 3.20 A; A/B/C/D=62-335
# PDB	4XDJ	X-ray; 3.80 A; A/B/C/D=62-335
# PDB	4XDK	X-ray; 3.60 A; A/B/C/D=62-335
# PDB	4XDL	X-ray; 3.50 A; A/B/C/D=62-335
# PRINTS	PR01333	2POREKCHANEL
# PRINTS	PR01499	TREKCHANNEL
# Pfam	PF07885	Ion_trans_2; 2
# Proteomes	UP000005640	Chromosome 14
# Reactome	R-HSA-1299503	TWIK related potassium channel (TREK)
# Reactome	R-HSA-5576886	Phase 4 - resting membrane potential
# RecName	KCNKA_HUMAN	Potassium channel subfamily K member 10
# RefSeq	NP_066984	NM_021161.4. [P57789-1]
# RefSeq	NP_612190	NM_138317.2. [P57789-3]
# RefSeq	NP_612191	NM_138318.2. [P57789-4]
# SIMILARITY	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCNKA_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TISSUE SPECIFICITY	KCNKA_HUMAN	Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain. 
# UCSC	uc001xwm	human. [P57789-1]
# eggNOG	COG1226	LUCA
# eggNOG	KOG1418	Eukaryota
BLAST	swissprot:KCNKA_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNKA_HUMAN
BioCyc	ZFISH:ENSG00000100433-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000100433-MONOMER
COXPRESdb	54207	http://coxpresdb.jp/data/gene/54207.shtml
CleanEx	HS_KCNK10	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNK10
DIP	DIP-44050N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-44050N
DOI	10.1038/bjp.2008.213	http://dx.doi.org/10.1038/bjp.2008.213
DOI	10.1038/nature01348	http://dx.doi.org/10.1038/nature01348
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M002822200	http://dx.doi.org/10.1074/jbc.M002822200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1113/jphysiol.2001.013432	http://dx.doi.org/10.1113/jphysiol.2001.013432
EMBL	AF279890	http://www.ebi.ac.uk/ena/data/view/AF279890
EMBL	AF385399	http://www.ebi.ac.uk/ena/data/view/AF385399
EMBL	AF385400	http://www.ebi.ac.uk/ena/data/view/AF385400
EMBL	AK313499	http://www.ebi.ac.uk/ena/data/view/AK313499
EMBL	AK315263	http://www.ebi.ac.uk/ena/data/view/AK315263
EMBL	AL049834	http://www.ebi.ac.uk/ena/data/view/AL049834
EMBL	AL133279	http://www.ebi.ac.uk/ena/data/view/AL133279
EMBL	BC075021	http://www.ebi.ac.uk/ena/data/view/BC075021
EMBL	BC075022	http://www.ebi.ac.uk/ena/data/view/BC075022
EMBL	CH471061	http://www.ebi.ac.uk/ena/data/view/CH471061
EMBL	CH471061	http://www.ebi.ac.uk/ena/data/view/CH471061
EMBL	CH471061	http://www.ebi.ac.uk/ena/data/view/CH471061
EMBL	EU978938	http://www.ebi.ac.uk/ena/data/view/EU978938
EMBL	EU978939	http://www.ebi.ac.uk/ena/data/view/EU978939
EMBL	EU978940	http://www.ebi.ac.uk/ena/data/view/EU978940
EMBL	EU978941	http://www.ebi.ac.uk/ena/data/view/EU978941
Ensembl	ENST00000312350	http://www.ensembl.org/id/ENST00000312350
Ensembl	ENST00000319231	http://www.ensembl.org/id/ENST00000319231
Ensembl	ENST00000340700	http://www.ensembl.org/id/ENST00000340700
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005244
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_function	GO:0022841	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022841
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007613	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007613
GO_process	GO:0030322	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030322
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	KCNK10	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNK10
GeneID	54207	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54207
GeneTree	ENSGT00760000118858	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118858
HGNC	HGNC:6273	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6273
HOGENOM	HOG000013106	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000013106&db=HOGENOM6
HOVERGEN	HBG052234	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052234&db=HOVERGEN
HPA	HPA030462	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA030462
InParanoid	P57789	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P57789
IntAct	P57789	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P57789*
InterPro	IPR003280	http://www.ebi.ac.uk/interpro/entry/IPR003280
InterPro	IPR003976	http://www.ebi.ac.uk/interpro/entry/IPR003976
InterPro	IPR013099	http://www.ebi.ac.uk/interpro/entry/IPR013099
Jabion	54207	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=54207
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:54207	http://www.genome.jp/dbget-bin/www_bget?hsa:54207
KEGG_Orthology	KO:K04920	http://www.genome.jp/dbget-bin/www_bget?KO:K04920
KEGG_Pathway	ko04971	http://www.genome.jp/kegg-bin/show_pathway?ko04971
MIM	605873	http://www.ncbi.nlm.nih.gov/omim/605873
MINT	MINT-4050532	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4050532
OMA	KQVNWDP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KQVNWDP
OrthoDB	EOG091G0E3R	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0E3R
PDB	4BW5	http://www.ebi.ac.uk/pdbe-srv/view/entry/4BW5
PDB	4XDJ	http://www.ebi.ac.uk/pdbe-srv/view/entry/4XDJ
PDB	4XDK	http://www.ebi.ac.uk/pdbe-srv/view/entry/4XDK
PDB	4XDL	http://www.ebi.ac.uk/pdbe-srv/view/entry/4XDL
PDBsum	4BW5	http://www.ebi.ac.uk/pdbsum/4BW5
PDBsum	4XDJ	http://www.ebi.ac.uk/pdbsum/4XDJ
PDBsum	4XDK	http://www.ebi.ac.uk/pdbsum/4XDK
PDBsum	4XDL	http://www.ebi.ac.uk/pdbsum/4XDL
PRINTS	PR01333	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01333
PRINTS	PR01499	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01499
PSORT	swissprot:KCNKA_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNKA_HUMAN
PSORT-B	swissprot:KCNKA_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNKA_HUMAN
PSORT2	swissprot:KCNKA_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNKA_HUMAN
Pfam	PF07885	http://pfam.xfam.org/family/PF07885
PharmGKB	PA30053	http://www.pharmgkb.org/do/serve?objId=PA30053&objCls=Gene
Phobius	swissprot:KCNKA_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNKA_HUMAN
PhylomeDB	P57789	http://phylomedb.org/?seqid=P57789
ProteinModelPortal	P57789	http://www.proteinmodelportal.org/query/uniprot/P57789
PubMed	10880510	http://www.ncbi.nlm.nih.gov/pubmed/10880510
PubMed	11897838	http://www.ncbi.nlm.nih.gov/pubmed/11897838
PubMed	12508121	http://www.ncbi.nlm.nih.gov/pubmed/12508121
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18516069	http://www.ncbi.nlm.nih.gov/pubmed/18516069
Reactome	R-HSA-1299503	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1299503
Reactome	R-HSA-5576886	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576886
RefSeq	NP_066984	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_066984
RefSeq	NP_612190	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_612190
RefSeq	NP_612191	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_612191
SMR	P57789	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P57789
STRING	9606.ENSP00000310568	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000310568&targetmode=cogs
UCSC	uc001xwm	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001xwm&org=rat
UniGene	Hs.560255	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.560255
UniProtKB	KCNKA_HUMAN	http://www.uniprot.org/uniprot/KCNKA_HUMAN
UniProtKB-AC	P57789	http://www.uniprot.org/uniprot/P57789
charge	swissprot:KCNKA_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNKA_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG1418	http://eggnogapi.embl.de/nog_data/html/tree/KOG1418
epestfind	swissprot:KCNKA_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNKA_HUMAN
garnier	swissprot:KCNKA_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNKA_HUMAN
helixturnhelix	swissprot:KCNKA_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNKA_HUMAN
hmoment	swissprot:KCNKA_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNKA_HUMAN
iep	swissprot:KCNKA_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNKA_HUMAN
inforesidue	swissprot:KCNKA_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNKA_HUMAN
neXtProt	NX_P57789	http://www.nextprot.org/db/entry/NX_P57789
octanol	swissprot:KCNKA_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNKA_HUMAN
pepcoil	swissprot:KCNKA_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNKA_HUMAN
pepdigest	swissprot:KCNKA_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNKA_HUMAN
pepinfo	swissprot:KCNKA_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNKA_HUMAN
pepnet	swissprot:KCNKA_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNKA_HUMAN
pepstats	swissprot:KCNKA_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNKA_HUMAN
pepwheel	swissprot:KCNKA_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNKA_HUMAN
pepwindow	swissprot:KCNKA_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNKA_HUMAN
sigcleave	swissprot:KCNKA_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNKA_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S22A8_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8TCC7-1; Sequence=Displayed; Name=2; IsoId=Q8TCC7-2; Sequence=VSP_022565; Note=No experimental confirmation available.; Name=5; IsoId=Q8TCC7-5; Sequence=VSP_045824; Note=No experimental confirmation available.; Name=3; IsoId=Q8TCC7-3; Sequence=VSP_022562, VSP_022563, VSP_022564; Note=No experimental confirmation available.; Name=4; IsoId=Q8TCC7-4; Sequence=VSP_045272; Note=No experimental confirmation available.; 
# AltName	S22A8_HUMAN	Organic anion transporter 3
# CCDS	CCDS53643	-. [Q8TCC7-5]
# CCDS	CCDS53644	-. [Q8TCC7-4]
# CCDS	CCDS8042	-. [Q8TCC7-1]
# CDD	cd06174	MFS
# DrugBank	DB00139	Succinic acid
# DrugBank	DB00168	Aspartame
# DrugBank	DB00175	Pravastatin
# DrugBank	DB00181	Baclofen
# DrugBank	DB00198	Oseltamivir
# DrugBank	DB00254	Doxycycline
# DrugBank	DB00279	Liothyronine
# DrugBank	DB00286	Conjugated Estrogens
# DrugBank	DB00300	Tenofovir
# DrugBank	DB00313	Valproic Acid
# DrugBank	DB00328	Indomethacin
# DrugBank	DB00345	Aminohippurate
# DrugBank	DB00390	Digoxin
# DrugBank	DB00437	Allopurinol
# DrugBank	DB00456	Cefalotin
# DrugBank	DB00469	Tenoxicam
# DrugBank	DB00493	Cefotaxime
# DrugBank	DB00495	Zidovudine
# DrugBank	DB00501	Cimetidine
# DrugBank	DB00536	Guanidine
# DrugBank	DB00554	Piroxicam
# DrugBank	DB00563	Methotrexate
# DrugBank	DB00567	Cephalexin
# DrugBank	DB00577	Valaciclovir
# DrugBank	DB00583	L-Carnitine
# DrugBank	DB00584	Enalapril
# DrugBank	DB00586	Diclofenac
# DrugBank	DB00595	Oxytetracycline
# DrugBank	DB00624	Testosterone
# DrugBank	DB00695	Furosemide
# DrugBank	DB00718	Adefovir Dipivoxil
# DrugBank	DB00759	Tetracycline
# DrugBank	DB00783	Estradiol
# DrugBank	DB00787	Aciclovir
# DrugBank	DB00812	Phenylbutazone
# DrugBank	DB00863	Ranitidine
# DrugBank	DB00887	Bumetanide
# DrugBank	DB00908	Quinidine
# DrugBank	DB00917	Dinoprostone
# DrugBank	DB00927	Famotidine
# DrugBank	DB00936	Salicylic acid
# DrugBank	DB01004	Ganciclovir
# DrugBank	DB01009	Ketoprofen
# DrugBank	DB01017	Minocycline
# DrugBank	DB01032	Probenecid
# DrugBank	DB01033	Mercaptopurine
# DrugBank	DB01050	Ibuprofen
# DrugBank	DB01051	Novobiocin
# DrugBank	DB01053	Benzylpenicillin
# DrugBank	DB01065	Melatonin
# DrugBank	DB01092	Ouabain
# DrugBank	DB01140	Cefadroxil
# DrugBank	DB01160	Dinoprost Tromethamine
# DrugBank	DB01212	Ceftriaxone
# DrugBank	DB01326	Cefamandole
# DrugBank	DB01327	Cefazolin
# DrugBank	DB01329	Cefoperazone
# DrugBank	DB01414	Cefacetrile
# DrugBank	DB01583	Liotrix
# DrugBank	DB01597	Cilastatin
# DrugBank	DB02659	Cholic Acid
# DrugBank	DB03793	Benzoic Acid
# DrugBank	DB06335	Saxagliptin
# DrugBank	DB06710	Methyltestosterone
# DrugBank	DB08912	Dabrafenib
# DrugBank	DB09060	Avibactam
# DrugBank	DB09272	Eluxadoline
# Ensembl	ENST00000336232	ENSP00000337335; ENSG00000149452. [Q8TCC7-1]
# Ensembl	ENST00000430500	ENSP00000398548; ENSG00000149452. [Q8TCC7-1]
# Ensembl	ENST00000535878	ENSP00000443368; ENSG00000149452. [Q8TCC7-5]
# Ensembl	ENST00000545207	ENSP00000441658; ENSG00000149452. [Q8TCC7-4]
# ExpressionAtlas	Q8TCC7	baseline and differential
# FUNCTION	S22A8_HUMAN	Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone- 3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA). {ECO 0000269|PubMed 14586168, ECO 0000269|PubMed 15644426, ECO 0000269|PubMed 15846473, ECO 0000269|PubMed 16455804}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016323	basolateral plasma membrane; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005452	inorganic anion exchanger activity; IDA:UniProtKB.
# GO_function	GO:0015347	sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
# GO_function	S22A8_HUMAN	GO 0015301 anion anion antiporter activity; TAS Reactome.
# GO_process	GO:0009636	response to toxic substance; IEA:UniProtKB-KW.
# GO_process	GO:0043252	sodium-independent organic anion transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q8TCC7	HS
# HGNC	HGNC:10972	SLC22A8
# InterPro	IPR004749	Orgcat_transp/SVOP
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR005829	Sugar_transporter_CS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04976	Bile secretion
# MIM	607581	gene
# Organism	S22A8_HUMAN	Homo sapiens (Human)
# PROSITE	PS50850	MFS
# Pfam	PF00083	Sugar_tr
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-561048	Organic anion transport
# RecName	S22A8_HUMAN	Solute carrier family 22 member 8
# RefSeq	NP_001171661	NM_001184732.1. [Q8TCC7-1]
# RefSeq	NP_001171662	NM_001184733.1. [Q8TCC7-4]
# RefSeq	NP_001171665	NM_001184736.1. [Q8TCC7-5]
# RefSeq	NP_004245	NM_004254.3. [Q8TCC7-1]
# RefSeq	XP_011543666	XM_011545364.1. [Q8TCC7-5]
# SEQUENCE CAUTION	Sequence=AAD19357.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=BAD92929.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S22A8_HUMAN	Basolateral cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. Note=Localizes on the brush border membrane of the choroid epithelial cells. Localizes to the basolateral membrane of the proximal tubular cells. Localizes on the abluminal and possibly, luminal membrane of the brain capillary endothelial cells (BCEC) (By similarity). {ECO 0000250}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.19.34	the major facilitator superfamily (mfs)
# TIGRFAMs	TIGR00898	2A0119
# TISSUE SPECIFICITY	Expressed in kidney. {ECO:0000269|PubMed	11912245}. 
# UCSC	uc001nwo	human. [Q8TCC7-1]
# eggNOG	COG0477	LUCA
# eggNOG	KOG0255	Eukaryota
BLAST	swissprot:S22A8_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S22A8_HUMAN
BioCyc	ZFISH:ENSG00000168534-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000168534-MONOMER
COXPRESdb	9376	http://coxpresdb.jp/data/gene/9376.shtml
CleanEx	HS_SLC22A8	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC22A8
DOI	10.1006/bbrc.1998.9978	http://dx.doi.org/10.1006/bbrc.1998.9978
DOI	10.1007/s11095-005-2503-0	http://dx.doi.org/10.1007/s11095-005-2503-0
DOI	10.1016/S0009-9236(03)00060-2	http://dx.doi.org/10.1016/S0009-9236(03)00060-2
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1124/dmd.105.008375	http://dx.doi.org/10.1124/dmd.105.008375
DOI	10.1124/jpet.104.080366	http://dx.doi.org/10.1124/jpet.104.080366
DOI	10.1152/ajprenal.00272.2005	http://dx.doi.org/10.1152/ajprenal.00272.2005
DOI	10.1159/000074539	http://dx.doi.org/10.1159/000074539
DrugBank	DB00139	http://www.drugbank.ca/drugs/DB00139
DrugBank	DB00168	http://www.drugbank.ca/drugs/DB00168
DrugBank	DB00175	http://www.drugbank.ca/drugs/DB00175
DrugBank	DB00181	http://www.drugbank.ca/drugs/DB00181
DrugBank	DB00198	http://www.drugbank.ca/drugs/DB00198
DrugBank	DB00254	http://www.drugbank.ca/drugs/DB00254
DrugBank	DB00279	http://www.drugbank.ca/drugs/DB00279
DrugBank	DB00286	http://www.drugbank.ca/drugs/DB00286
DrugBank	DB00300	http://www.drugbank.ca/drugs/DB00300
DrugBank	DB00313	http://www.drugbank.ca/drugs/DB00313
DrugBank	DB00328	http://www.drugbank.ca/drugs/DB00328
DrugBank	DB00345	http://www.drugbank.ca/drugs/DB00345
DrugBank	DB00390	http://www.drugbank.ca/drugs/DB00390
DrugBank	DB00437	http://www.drugbank.ca/drugs/DB00437
DrugBank	DB00456	http://www.drugbank.ca/drugs/DB00456
DrugBank	DB00469	http://www.drugbank.ca/drugs/DB00469
DrugBank	DB00493	http://www.drugbank.ca/drugs/DB00493
DrugBank	DB00495	http://www.drugbank.ca/drugs/DB00495
DrugBank	DB00501	http://www.drugbank.ca/drugs/DB00501
DrugBank	DB00536	http://www.drugbank.ca/drugs/DB00536
DrugBank	DB00554	http://www.drugbank.ca/drugs/DB00554
DrugBank	DB00563	http://www.drugbank.ca/drugs/DB00563
DrugBank	DB00567	http://www.drugbank.ca/drugs/DB00567
DrugBank	DB00577	http://www.drugbank.ca/drugs/DB00577
DrugBank	DB00583	http://www.drugbank.ca/drugs/DB00583
DrugBank	DB00584	http://www.drugbank.ca/drugs/DB00584
DrugBank	DB00586	http://www.drugbank.ca/drugs/DB00586
DrugBank	DB00595	http://www.drugbank.ca/drugs/DB00595
DrugBank	DB00624	http://www.drugbank.ca/drugs/DB00624
DrugBank	DB00695	http://www.drugbank.ca/drugs/DB00695
DrugBank	DB00718	http://www.drugbank.ca/drugs/DB00718
DrugBank	DB00759	http://www.drugbank.ca/drugs/DB00759
DrugBank	DB00783	http://www.drugbank.ca/drugs/DB00783
DrugBank	DB00787	http://www.drugbank.ca/drugs/DB00787
DrugBank	DB00812	http://www.drugbank.ca/drugs/DB00812
DrugBank	DB00863	http://www.drugbank.ca/drugs/DB00863
DrugBank	DB00887	http://www.drugbank.ca/drugs/DB00887
DrugBank	DB00908	http://www.drugbank.ca/drugs/DB00908
DrugBank	DB00917	http://www.drugbank.ca/drugs/DB00917
DrugBank	DB00927	http://www.drugbank.ca/drugs/DB00927
DrugBank	DB00936	http://www.drugbank.ca/drugs/DB00936
DrugBank	DB01004	http://www.drugbank.ca/drugs/DB01004
DrugBank	DB01009	http://www.drugbank.ca/drugs/DB01009
DrugBank	DB01017	http://www.drugbank.ca/drugs/DB01017
DrugBank	DB01032	http://www.drugbank.ca/drugs/DB01032
DrugBank	DB01033	http://www.drugbank.ca/drugs/DB01033
DrugBank	DB01050	http://www.drugbank.ca/drugs/DB01050
DrugBank	DB01051	http://www.drugbank.ca/drugs/DB01051
DrugBank	DB01053	http://www.drugbank.ca/drugs/DB01053
DrugBank	DB01065	http://www.drugbank.ca/drugs/DB01065
DrugBank	DB01092	http://www.drugbank.ca/drugs/DB01092
DrugBank	DB01140	http://www.drugbank.ca/drugs/DB01140
DrugBank	DB01160	http://www.drugbank.ca/drugs/DB01160
DrugBank	DB01212	http://www.drugbank.ca/drugs/DB01212
DrugBank	DB01326	http://www.drugbank.ca/drugs/DB01326
DrugBank	DB01327	http://www.drugbank.ca/drugs/DB01327
DrugBank	DB01329	http://www.drugbank.ca/drugs/DB01329
DrugBank	DB01414	http://www.drugbank.ca/drugs/DB01414
DrugBank	DB01583	http://www.drugbank.ca/drugs/DB01583
DrugBank	DB01597	http://www.drugbank.ca/drugs/DB01597
DrugBank	DB02659	http://www.drugbank.ca/drugs/DB02659
DrugBank	DB03793	http://www.drugbank.ca/drugs/DB03793
DrugBank	DB06335	http://www.drugbank.ca/drugs/DB06335
DrugBank	DB06710	http://www.drugbank.ca/drugs/DB06710
DrugBank	DB08912	http://www.drugbank.ca/drugs/DB08912
DrugBank	DB09060	http://www.drugbank.ca/drugs/DB09060
DrugBank	DB09272	http://www.drugbank.ca/drugs/DB09272
EMBL	AB042505	http://www.ebi.ac.uk/ena/data/view/AB042505
EMBL	AB209692	http://www.ebi.ac.uk/ena/data/view/AB209692
EMBL	AF097491	http://www.ebi.ac.uk/ena/data/view/AF097491
EMBL	AK298341	http://www.ebi.ac.uk/ena/data/view/AK298341
EMBL	AP001858	http://www.ebi.ac.uk/ena/data/view/AP001858
EMBL	BC022387	http://www.ebi.ac.uk/ena/data/view/BC022387
Ensembl	ENST00000336232	http://www.ensembl.org/id/ENST00000336232
Ensembl	ENST00000430500	http://www.ensembl.org/id/ENST00000430500
Ensembl	ENST00000535878	http://www.ensembl.org/id/ENST00000535878
Ensembl	ENST00000545207	http://www.ensembl.org/id/ENST00000545207
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005452	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005452
GO_function	GO:0015301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015301
GO_function	GO:0015347	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015347
GO_process	GO:0009636	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009636
GO_process	GO:0043252	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043252
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	SLC22A8	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC22A8
GeneID	9376	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9376
GeneTree	ENSGT00760000118852	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118852
HGNC	HGNC:10972	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10972
HOGENOM	HOG000234569	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234569&db=HOGENOM6
HOVERGEN	HBG108433	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108433&db=HOVERGEN
HPA	HPA044174	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA044174
InParanoid	Q8TCC7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8TCC7
IntAct	Q8TCC7	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8TCC7*
InterPro	IPR004749	http://www.ebi.ac.uk/interpro/entry/IPR004749
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR005829	http://www.ebi.ac.uk/interpro/entry/IPR005829
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	9376	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9376
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:9376	http://www.genome.jp/dbget-bin/www_bget?hsa:9376
KEGG_Orthology	KO:K08205	http://www.genome.jp/dbget-bin/www_bget?KO:K08205
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
MIM	607581	http://www.ncbi.nlm.nih.gov/omim/607581
OMA	SMESRFE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SMESRFE
OrthoDB	EOG091G0738	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0738
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:S22A8_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S22A8_HUMAN
PSORT-B	swissprot:S22A8_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S22A8_HUMAN
PSORT2	swissprot:S22A8_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S22A8_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
PharmGKB	PA389	http://www.pharmgkb.org/do/serve?objId=PA389&objCls=Gene
Phobius	swissprot:S22A8_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S22A8_HUMAN
PhylomeDB	Q8TCC7	http://phylomedb.org/?seqid=Q8TCC7
ProteinModelPortal	Q8TCC7	http://www.proteinmodelportal.org/query/uniprot/Q8TCC7
PubMed	10049739	http://www.ncbi.nlm.nih.gov/pubmed/10049739
PubMed	11912245	http://www.ncbi.nlm.nih.gov/pubmed/11912245
PubMed	12811365	http://www.ncbi.nlm.nih.gov/pubmed/12811365
PubMed	14586168	http://www.ncbi.nlm.nih.gov/pubmed/14586168
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15644426	http://www.ncbi.nlm.nih.gov/pubmed/15644426
PubMed	15846473	http://www.ncbi.nlm.nih.gov/pubmed/15846473
PubMed	16291576	http://www.ncbi.nlm.nih.gov/pubmed/16291576
PubMed	16455804	http://www.ncbi.nlm.nih.gov/pubmed/16455804
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
Reactome	R-HSA-561048	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-561048
RefSeq	NP_001171661	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001171661
RefSeq	NP_001171662	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001171662
RefSeq	NP_001171665	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001171665
RefSeq	NP_004245	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004245
RefSeq	XP_011543666	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011543666
STRING	9606.ENSP00000337335	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000337335&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.19.34	http://www.tcdb.org/search/result.php?tc=2.A.1.19.34
TIGRFAMs	TIGR00898	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00898
UCSC	uc001nwo	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001nwo&org=rat
UniGene	Hs.266223	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.266223
UniProtKB	S22A8_HUMAN	http://www.uniprot.org/uniprot/S22A8_HUMAN
UniProtKB-AC	Q8TCC7	http://www.uniprot.org/uniprot/Q8TCC7
charge	swissprot:S22A8_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S22A8_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG0255	http://eggnogapi.embl.de/nog_data/html/tree/KOG0255
epestfind	swissprot:S22A8_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S22A8_HUMAN
garnier	swissprot:S22A8_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S22A8_HUMAN
helixturnhelix	swissprot:S22A8_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S22A8_HUMAN
hmoment	swissprot:S22A8_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S22A8_HUMAN
iep	swissprot:S22A8_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S22A8_HUMAN
inforesidue	swissprot:S22A8_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S22A8_HUMAN
neXtProt	NX_Q8TCC7	http://www.nextprot.org/db/entry/NX_Q8TCC7
octanol	swissprot:S22A8_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S22A8_HUMAN
pepcoil	swissprot:S22A8_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S22A8_HUMAN
pepdigest	swissprot:S22A8_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S22A8_HUMAN
pepinfo	swissprot:S22A8_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S22A8_HUMAN
pepnet	swissprot:S22A8_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S22A8_HUMAN
pepstats	swissprot:S22A8_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S22A8_HUMAN
pepwheel	swissprot:S22A8_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S22A8_HUMAN
pepwindow	swissprot:S22A8_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S22A8_HUMAN
sigcleave	swissprot:S22A8_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S22A8_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S15A2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q16348-1; Sequence=Displayed; Name=2; IsoId=Q16348-2; Sequence=VSP_043084; Note=No experimental confirmation available.; 
# AltName	S15A2_HUMAN	Kidney H(+)/peptide cotransporter
# AltName	S15A2_HUMAN	Oligopeptide transporter, kidney isoform
# AltName	S15A2_HUMAN	Peptide transporter 2
# CCDS	CCDS3007	-. [Q16348-1]
# CCDS	CCDS54631	-. [Q16348-2]
# CDD	cd06174	MFS
# DrugBank	DB00178	Ramipril
# DrugBank	DB00274	Cefmetazole
# DrugBank	DB00302	Tranexamic Acid
# DrugBank	DB00415	Ampicillin
# DrugBank	DB00438	Ceftazidime
# DrugBank	DB00456	Cefalotin
# DrugBank	DB00485	Dicloxacillin
# DrugBank	DB00492	Fosinopril
# DrugBank	DB00493	Cefotaxime
# DrugBank	DB00519	Trandolapril
# DrugBank	DB00535	Cefdinir
# DrugBank	DB00542	Benazepril
# DrugBank	DB00567	Cephalexin
# DrugBank	DB00577	Valaciclovir
# DrugBank	DB00671	Cefixime
# DrugBank	DB00672	Chlorpropamide
# DrugBank	DB00691	Moexipril
# DrugBank	DB00713	Oxacillin
# DrugBank	DB00731	Nateglinide
# DrugBank	DB00790	Perindopril
# DrugBank	DB00833	Cefaclor
# DrugBank	DB00855	Aminolevulinic acid
# DrugBank	DB00881	Quinapril
# DrugBank	DB01000	Cyclacillin
# DrugBank	DB01016	Glyburide
# DrugBank	DB01053	Benzylpenicillin
# DrugBank	DB01060	Amoxicillin
# DrugBank	DB01112	Cefuroxime
# DrugBank	DB01124	Tolbutamide
# DrugBank	DB01140	Cefadroxil
# DrugBank	DB01147	Cloxacillin
# DrugBank	DB01212	Ceftriaxone
# DrugBank	DB01333	Cefradine
# DrugBank	DB01340	Cilazapril
# DrugBank	DB01348	Spirapril
# DrugBank	DB01413	Cefepime
# DrugBank	DB01415	Ceftibuten
# DrugBank	DB01610	Valganciclovir
# DrugBank	DB08795	Azidocillin
# Ensembl	ENST00000295605	ENSP00000295605; ENSG00000163406. [Q16348-2]
# Ensembl	ENST00000489711	ENSP00000417085; ENSG00000163406. [Q16348-1]
# ExpressionAtlas	Q16348	baseline and differential
# FUNCTION	S15A2_HUMAN	Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0015198	oligopeptide transporter activity; IEA:InterPro.
# GO_function	S15A2_HUMAN	GO 0015333 peptide proton symporter activity; TAS Reactome.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0015031	protein transport; IEA:UniProtKB-KW.
# GO_process	GO:0015893	drug transport; NAS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q16348	HS
# HGNC	HGNC:10921	SLC15A2
# InterPro	IPR000109	POT_fam
# InterPro	IPR004768	Oligopep_transport
# InterPro	IPR018456	PTR2_symporter_CS
# InterPro	IPR020846	MFS_dom
# InterPro	IPR029028	Alpha/beta_knot_MTases
# KEGG_Brite	ko02001	Solute carrier family
# MIM	602339	gene
# Organism	S15A2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11654	PTHR11654; 2
# PIR	I52481	I52481
# PROSITE	PS01022	PTR2_1
# PROSITE	PS01023	PTR2_2
# Pfam	PF00854	PTR2; 2
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-427975	Proton/oligopeptide cotransporters
# RecName	S15A2_HUMAN	Solute carrier family 15 member 2
# RefSeq	NP_001139470	NM_001145998.1. [Q16348-2]
# RefSeq	NP_066568	NM_021082.3. [Q16348-1]
# SIMILARITY	Belongs to the PTR2/POT transporter (TC 2.A.17) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S15A2_HUMAN	Membrane; Multi-pass membrane protein. 
# SUPFAM	SSF103473	SSF103473; 2
# SUPFAM	SSF75217	SSF75217
# TCDB	2.A.17.4	the proton-dependent oligopeptide transporter (pot/ptr) family
# TIGRFAMs	TIGR00926	2A1704
# UCSC	uc003eep	human. [Q16348-1]
# eggNOG	COG3104	LUCA
# eggNOG	KOG1237	Eukaryota
BLAST	swissprot:S15A2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S15A2_HUMAN
BioCyc	ZFISH:ENSG00000163406-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000163406-MONOMER
COXPRESdb	6565	http://coxpresdb.jp/data/gene/6565.shtml
CleanEx	HS_SLC15A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC15A2
DOI	10.1016/0005-2736(95)80036-F	http://dx.doi.org/10.1016/0005-2736(95)80036-F
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DrugBank	DB00178	http://www.drugbank.ca/drugs/DB00178
DrugBank	DB00274	http://www.drugbank.ca/drugs/DB00274
DrugBank	DB00302	http://www.drugbank.ca/drugs/DB00302
DrugBank	DB00415	http://www.drugbank.ca/drugs/DB00415
DrugBank	DB00438	http://www.drugbank.ca/drugs/DB00438
DrugBank	DB00456	http://www.drugbank.ca/drugs/DB00456
DrugBank	DB00485	http://www.drugbank.ca/drugs/DB00485
DrugBank	DB00492	http://www.drugbank.ca/drugs/DB00492
DrugBank	DB00493	http://www.drugbank.ca/drugs/DB00493
DrugBank	DB00519	http://www.drugbank.ca/drugs/DB00519
DrugBank	DB00535	http://www.drugbank.ca/drugs/DB00535
DrugBank	DB00542	http://www.drugbank.ca/drugs/DB00542
DrugBank	DB00567	http://www.drugbank.ca/drugs/DB00567
DrugBank	DB00577	http://www.drugbank.ca/drugs/DB00577
DrugBank	DB00671	http://www.drugbank.ca/drugs/DB00671
DrugBank	DB00672	http://www.drugbank.ca/drugs/DB00672
DrugBank	DB00691	http://www.drugbank.ca/drugs/DB00691
DrugBank	DB00713	http://www.drugbank.ca/drugs/DB00713
DrugBank	DB00731	http://www.drugbank.ca/drugs/DB00731
DrugBank	DB00790	http://www.drugbank.ca/drugs/DB00790
DrugBank	DB00833	http://www.drugbank.ca/drugs/DB00833
DrugBank	DB00855	http://www.drugbank.ca/drugs/DB00855
DrugBank	DB00881	http://www.drugbank.ca/drugs/DB00881
DrugBank	DB01000	http://www.drugbank.ca/drugs/DB01000
DrugBank	DB01016	http://www.drugbank.ca/drugs/DB01016
DrugBank	DB01053	http://www.drugbank.ca/drugs/DB01053
DrugBank	DB01060	http://www.drugbank.ca/drugs/DB01060
DrugBank	DB01112	http://www.drugbank.ca/drugs/DB01112
DrugBank	DB01124	http://www.drugbank.ca/drugs/DB01124
DrugBank	DB01140	http://www.drugbank.ca/drugs/DB01140
DrugBank	DB01147	http://www.drugbank.ca/drugs/DB01147
DrugBank	DB01212	http://www.drugbank.ca/drugs/DB01212
DrugBank	DB01333	http://www.drugbank.ca/drugs/DB01333
DrugBank	DB01340	http://www.drugbank.ca/drugs/DB01340
DrugBank	DB01348	http://www.drugbank.ca/drugs/DB01348
DrugBank	DB01413	http://www.drugbank.ca/drugs/DB01413
DrugBank	DB01415	http://www.drugbank.ca/drugs/DB01415
DrugBank	DB01610	http://www.drugbank.ca/drugs/DB01610
DrugBank	DB08795	http://www.drugbank.ca/drugs/DB08795
EMBL	AC072031	http://www.ebi.ac.uk/ena/data/view/AC072031
EMBL	AK289820	http://www.ebi.ac.uk/ena/data/view/AK289820
EMBL	AK304189	http://www.ebi.ac.uk/ena/data/view/AK304189
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
EMBL	S78203	http://www.ebi.ac.uk/ena/data/view/S78203
Ensembl	ENST00000295605	http://www.ensembl.org/id/ENST00000295605
Ensembl	ENST00000489711	http://www.ensembl.org/id/ENST00000489711
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0015198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015198
GO_function	GO:0015333	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015333
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0015031	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031
GO_process	GO:0015893	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015893
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC15A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC15A2
GeneID	6565	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6565
GeneTree	ENSGT00530000062961	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062961
H-InvDB	HIX0024323	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0024323
HGNC	HGNC:10921	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10921
HOGENOM	HOG000285186	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000285186&db=HOGENOM6
HOVERGEN	HBG052962	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052962&db=HOVERGEN
InParanoid	Q16348	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q16348
InterPro	IPR000109	http://www.ebi.ac.uk/interpro/entry/IPR000109
InterPro	IPR004768	http://www.ebi.ac.uk/interpro/entry/IPR004768
InterPro	IPR018456	http://www.ebi.ac.uk/interpro/entry/IPR018456
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
InterPro	IPR029028	http://www.ebi.ac.uk/interpro/entry/IPR029028
Jabion	6565	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6565
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6565	http://www.genome.jp/dbget-bin/www_bget?hsa:6565
KEGG_Orthology	KO:K14637	http://www.genome.jp/dbget-bin/www_bget?KO:K14637
MIM	602339	http://www.ncbi.nlm.nih.gov/omim/602339
OMA	FHLKYHN	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FHLKYHN
OrthoDB	EOG091G0M1S	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0M1S
PANTHER	PTHR11654	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11654
PROSITE	PS01022	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01022
PROSITE	PS01023	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01023
PSORT	swissprot:S15A2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S15A2_HUMAN
PSORT-B	swissprot:S15A2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S15A2_HUMAN
PSORT2	swissprot:S15A2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S15A2_HUMAN
Pfam	PF00854	http://pfam.xfam.org/family/PF00854
PharmGKB	PA35812	http://www.pharmgkb.org/do/serve?objId=PA35812&objCls=Gene
Phobius	swissprot:S15A2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S15A2_HUMAN
PhylomeDB	Q16348	http://phylomedb.org/?seqid=Q16348
ProteinModelPortal	Q16348	http://www.proteinmodelportal.org/query/uniprot/Q16348
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	7756356	http://www.ncbi.nlm.nih.gov/pubmed/7756356
Reactome	R-HSA-427975	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-427975
RefSeq	NP_001139470	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001139470
RefSeq	NP_066568	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_066568
STRING	9606.ENSP00000417085	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000417085&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
SUPFAM	SSF75217	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF75217
TCDB	2.A.17.4	http://www.tcdb.org/search/result.php?tc=2.A.17.4
TIGRFAMs	TIGR00926	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00926
UCSC	uc003eep	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003eep&org=rat
UniGene	Hs.518089	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.518089
UniProtKB	S15A2_HUMAN	http://www.uniprot.org/uniprot/S15A2_HUMAN
UniProtKB-AC	Q16348	http://www.uniprot.org/uniprot/Q16348
charge	swissprot:S15A2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S15A2_HUMAN
eggNOG	COG3104	http://eggnogapi.embl.de/nog_data/html/tree/COG3104
eggNOG	KOG1237	http://eggnogapi.embl.de/nog_data/html/tree/KOG1237
epestfind	swissprot:S15A2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S15A2_HUMAN
garnier	swissprot:S15A2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S15A2_HUMAN
helixturnhelix	swissprot:S15A2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S15A2_HUMAN
hmoment	swissprot:S15A2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S15A2_HUMAN
iep	swissprot:S15A2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S15A2_HUMAN
inforesidue	swissprot:S15A2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S15A2_HUMAN
neXtProt	NX_Q16348	http://www.nextprot.org/db/entry/NX_Q16348
octanol	swissprot:S15A2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S15A2_HUMAN
pepcoil	swissprot:S15A2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S15A2_HUMAN
pepdigest	swissprot:S15A2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S15A2_HUMAN
pepinfo	swissprot:S15A2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S15A2_HUMAN
pepnet	swissprot:S15A2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S15A2_HUMAN
pepstats	swissprot:S15A2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S15A2_HUMAN
pepwheel	swissprot:S15A2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S15A2_HUMAN
pepwindow	swissprot:S15A2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S15A2_HUMAN
sigcleave	swissprot:S15A2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S15A2_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCJ14_HUMAN	Inward rectifier K(+) channel Kir2.4
# AltName	KCJ14_HUMAN	Potassium channel, inwardly rectifying subfamily J member 14
# DrugBank	DB01392	Yohimbine
# Ensembl	ENST00000342291	ENSP00000341479; ENSG00000182324
# Ensembl	ENST00000391884	ENSP00000375756; ENSG00000182324
# FUNCTION	KCJ14_HUMAN	Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium (By similarity). {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008076	voltage-gated potassium channel complex; TAS:ProtInc.
# GO_component	GO:0030425	dendrite; IEA:Ensembl.
# GO_component	GO:0043025	neuronal cell body; IEA:Ensembl.
# GO_function	GO:0005242	inward rectifier potassium channel activity; TAS:ProtInc.
# GO_process	GO:0010107	potassium ion import; IBA:GO_Central.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.40.1400	-; 1.
# Genevisible	Q9UNX9	HS
# HGNC	HGNC:6260	KCNJ14
# InterPro	IPR013518	K_chnl_inward-rec_Kir_cyto
# InterPro	IPR014756	Ig_E-set
# InterPro	IPR016449	K_chnl_inward-rec_Kir
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04725	Cholinergic synapse
# MIM	603953	gene
# Organism	KCJ14_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11767	PTHR11767
# PIRSF	PIRSF005465	GIRK_kir
# PRINTS	PR01320	KIRCHANNEL
# Pfam	PF01007	IRK
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-1296053	Classical Kir channels
# Reactome	R-HSA-5576886	Phase 4 - resting membrane potential
# RecName	KCJ14_HUMAN	ATP-sensitive inward rectifier potassium channel 14
# RefSeq	NP_037480	NM_013348.3
# SIMILARITY	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ14 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCJ14_HUMAN	Membrane; Multi-pass membrane protein. 
# SUPFAM	SSF81296	SSF81296
# TISSUE SPECIFICITY	Expressed preferentially in retina. {ECO:0000269|PubMed	10942728}. 
# UCSC	uc002pje	human
# eggNOG	ENOG410XQ62	LUCA
# eggNOG	KOG3827	Eukaryota
BLAST	swissprot:KCJ14_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCJ14_HUMAN
COXPRESdb	3770	http://coxpresdb.jp/data/gene/3770.shtml
CleanEx	HS_KCNJ14	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNJ14
DOI	10.1007/s003350010047	http://dx.doi.org/10.1007/s003350010047
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB01392	http://www.drugbank.ca/drugs/DB01392
EMBL	AF081466	http://www.ebi.ac.uk/ena/data/view/AF081466
EMBL	AF181988	http://www.ebi.ac.uk/ena/data/view/AF181988
EMBL	BC035918	http://www.ebi.ac.uk/ena/data/view/BC035918
Ensembl	ENST00000342291	http://www.ensembl.org/id/ENST00000342291
Ensembl	ENST00000391884	http://www.ensembl.org/id/ENST00000391884
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_function	GO:0005242	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005242
GO_process	GO:0010107	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010107
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.40.1400	http://www.cathdb.info/version/latest/superfamily/2.60.40.1400
GeneCards	KCNJ14	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNJ14
GeneID	3770	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3770
GeneTree	ENSGT00760000118842	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118842
HGNC	HGNC:6260	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6260
HOGENOM	HOG000237325	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237325&db=HOGENOM6
HOVERGEN	HBG006178	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006178&db=HOVERGEN
HPA	HPA071765	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA071765
InParanoid	Q9UNX9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UNX9
InterPro	IPR013518	http://www.ebi.ac.uk/interpro/entry/IPR013518
InterPro	IPR014756	http://www.ebi.ac.uk/interpro/entry/IPR014756
InterPro	IPR016449	http://www.ebi.ac.uk/interpro/entry/IPR016449
Jabion	3770	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3770
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3770	http://www.genome.jp/dbget-bin/www_bget?hsa:3770
KEGG_Orthology	KO:K05007	http://www.genome.jp/dbget-bin/www_bget?KO:K05007
KEGG_Pathway	ko04725	http://www.genome.jp/kegg-bin/show_pathway?ko04725
MIM	603953	http://www.ncbi.nlm.nih.gov/omim/603953
OMA	CRNGWVP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CRNGWVP
OrthoDB	EOG091G08HC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08HC
PANTHER	PTHR11767	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11767
PRINTS	PR01320	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01320
PSORT	swissprot:KCJ14_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCJ14_HUMAN
PSORT-B	swissprot:KCJ14_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCJ14_HUMAN
PSORT2	swissprot:KCJ14_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCJ14_HUMAN
Pfam	PF01007	http://pfam.xfam.org/family/PF01007
PharmGKB	PA30045	http://www.pharmgkb.org/do/serve?objId=PA30045&objCls=Gene
Phobius	swissprot:KCJ14_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCJ14_HUMAN
PhylomeDB	Q9UNX9	http://phylomedb.org/?seqid=Q9UNX9
ProteinModelPortal	Q9UNX9	http://www.proteinmodelportal.org/query/uniprot/Q9UNX9
PubMed	10723734	http://www.ncbi.nlm.nih.gov/pubmed/10723734
PubMed	10942728	http://www.ncbi.nlm.nih.gov/pubmed/10942728
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-1296053	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296053
Reactome	R-HSA-5576886	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576886
RefSeq	NP_037480	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_037480
SMR	Q9UNX9	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9UNX9
STRING	9606.ENSP00000341479	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000341479&targetmode=cogs
SUPFAM	SSF81296	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81296
UCSC	uc002pje	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002pje&org=rat
UniGene	Hs.144011	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.144011
UniGene	Hs.745133	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.745133
UniProtKB	KCJ14_HUMAN	http://www.uniprot.org/uniprot/KCJ14_HUMAN
UniProtKB-AC	Q9UNX9	http://www.uniprot.org/uniprot/Q9UNX9
charge	swissprot:KCJ14_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCJ14_HUMAN
eggNOG	ENOG410XQ62	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ62
eggNOG	KOG3827	http://eggnogapi.embl.de/nog_data/html/tree/KOG3827
epestfind	swissprot:KCJ14_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCJ14_HUMAN
garnier	swissprot:KCJ14_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCJ14_HUMAN
helixturnhelix	swissprot:KCJ14_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCJ14_HUMAN
hmoment	swissprot:KCJ14_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCJ14_HUMAN
iep	swissprot:KCJ14_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCJ14_HUMAN
inforesidue	swissprot:KCJ14_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCJ14_HUMAN
neXtProt	NX_Q9UNX9	http://www.nextprot.org/db/entry/NX_Q9UNX9
octanol	swissprot:KCJ14_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCJ14_HUMAN
pepcoil	swissprot:KCJ14_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCJ14_HUMAN
pepdigest	swissprot:KCJ14_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCJ14_HUMAN
pepinfo	swissprot:KCJ14_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCJ14_HUMAN
pepnet	swissprot:KCJ14_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCJ14_HUMAN
pepstats	swissprot:KCJ14_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCJ14_HUMAN
pepwheel	swissprot:KCJ14_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCJ14_HUMAN
pepwindow	swissprot:KCJ14_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCJ14_HUMAN
sigcleave	swissprot:KCJ14_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCJ14_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CMC2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UJS0-1; Sequence=Displayed; Name=2; IsoId=Q9UJS0-2; Sequence=VSP_043747; 
# AltName	CMC2_HUMAN	Citrin
# AltName	CMC2_HUMAN	Mitochondrial aspartate glutamate carrier 2
# AltName	CMC2_HUMAN	Solute carrier family 25 member 13
# BioGrid	115467	44
# CCDS	CCDS55130	-. [Q9UJS0-2]
# CCDS	CCDS5645	-. [Q9UJS0-1]
# ChiTaRS	SLC25A13	human
# DISEASE	CMC2_HUMAN	Cholestasis, neonatal intrahepatic, caused by citrin deficiency (NICCD) [MIM 605814]  A form of citrullinemia type 2 with neonatal onset, characterized by suppression of the bile flow, hepatic fibrosis, low birth weight, growth retardation, hypoproteinemia, variable liver dysfunction. Neonatal intrahepatic cholestasis due to citrin deficiency is generally not severe and symptoms disappear by one year of age with an appropriate diet. Years or even decades later, however, some individuals develop the characteristic features of citrullinemia type 2 with neuropsychiatric symptoms. {ECO 0000269|PubMed 11793471}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CMC2_HUMAN	Citrullinemia 2 (CTLN2) [MIM 603471]  A form of citrullinemia, an autosomal recessive disease characterized primarily by elevated serum and urine citrulline levels. Ammonia intoxication is another manifestation. Citrullinemia type 2 is characterized by neuropsychiatric symptoms including abnormal behaviors, loss of memory, seizures and coma. Death can result from brain edema. Onset is sudden and usually between the ages of 20 and 50 years. {ECO 0000269|PubMed 10369257, ECO 0000269|PubMed 10610724}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00128	L-Aspartic Acid
# Ensembl	ENST00000265631	ENSP00000265631; ENSG00000004864. [Q9UJS0-1]
# Ensembl	ENST00000416240	ENSP00000400101; ENSG00000004864. [Q9UJS0-2]
# ExpressionAtlas	Q9UJS0	baseline and differential
# FUNCTION	CMC2_HUMAN	Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle. {ECO 0000269|PubMed 11566871}. 
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; ISS:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; NAS:UniProtKB.
# GO_function	GO:0005215	transporter activity; NAS:UniProtKB.
# GO_function	GO:0005313	L-glutamate transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0005509	calcium ion binding; IDA:UniProtKB.
# GO_function	GO:0015172	acidic amino acid transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015183	L-aspartate transmembrane transporter activity; IDA:UniProtKB.
# GO_process	GO:0006094	gluconeogenesis; TAS:Reactome.
# GO_process	GO:0006754	ATP biosynthetic process; IDA:UniProtKB.
# GO_process	GO:0006810	transport; NAS:UniProtKB.
# GO_process	GO:0015810	aspartate transport; IDA:UniProtKB.
# GO_process	GO:0015813	L-glutamate transport; IDA:UniProtKB.
# GO_process	GO:0043490	malate-aspartate shuttle; IDA:UniProtKB.
# GO_process	GO:0045333	cellular respiration; IDA:UniProtKB.
# GO_process	GO:0051592	response to calcium ion; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0005975	carbohydrate metabolic process
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# Gene3D	1.10.238.10	-; 2.
# Gene3D	1.50.40.10	-; 1.
# Genevisible	Q9UJS0	HS
# HGNC	HGNC:10983	SLC25A13
# IntAct	Q9UJS0	49
# InterPro	IPR002048	EF_hand_dom
# InterPro	IPR002067	Mit_carrier
# InterPro	IPR011992	EF-hand-dom_pair
# InterPro	IPR018108	Mitochondrial_sb/sol_carrier
# InterPro	IPR023395	Mt_carrier_dom
# InterPro	IPR029658	Aralar2
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H00185	[Inherited metabolic disease; Nervous system disease] Citrullinemia (CTLN)
# KEGG_Disease	H01398:[Inherited metabolic disease] Citrullinemia type II  [DS	H00185]
# MIM	603471	phenotype
# MIM	603859	gene
# MIM	605814	phenotype
# MISCELLANEOUS	CMC2_HUMAN	Binds calcium. 
# Organism	CMC2_HUMAN	Homo sapiens (Human)
# Orphanet	247585	Citrullinemia type II
# Orphanet	247598	Neonatal intrahepatic cholestasis due to citrin deficiency
# PANTHER	PTHR24089:SF265	PTHR24089:SF265
# PDB	4P5W	X-ray; 2.40 A; A/B=2-319, A/B=612-675
# PRINTS	PR00926	MITOCARRIER
# PROSITE	PS50222	EF_HAND_2; 2
# PROSITE	PS50920	SOLCAR; 3
# Pfam	PF00153	Mito_carr; 3
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-1268020	Mitochondrial protein import
# Reactome	R-HSA-70263	Gluconeogenesis
# RecName	CMC2_HUMAN	Calcium-binding mitochondrial carrier protein Aralar2
# RefSeq	NP_001153682	NM_001160210.1. [Q9UJS0-2]
# RefSeq	NP_055066	NM_014251.2. [Q9UJS0-1]
# SEQUENCE CAUTION	Sequence=AAB67049.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAB70112.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the mitochondrial carrier (TC 2.A.29) family. {ECO	0000305}. 
# SIMILARITY	Contains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule	PRU00282}. 
# SIMILARITY	Contains 4 EF-hand domains. {ECO:0000255|PROSITE- ProRule	PRU00448}. 
# SUBCELLULAR LOCATION	CMC2_HUMAN	Mitochondrion inner membrane {ECO 0000269|PubMed 10642534}; Multi-pass membrane protein {ECO 0000269|PubMed 10642534}. 
# SUPFAM	SSF103506	SSF103506
# SUPFAM	SSF47473	SSF47473; 2
# TCDB	2.A.29.14	the mitochondrial carrier (mc) family
# TISSUE SPECIFICITY	CMC2_HUMAN	High levels in liver and low levels in kidney, pancreas, placenta, heart and brain. {ECO 0000269|PubMed 10369257, ECO 0000269|PubMed 10642534}. 
# UCSC	uc003uof	human. [Q9UJS0-1]
# eggNOG	ENOG410XNRM	LUCA
# eggNOG	KOG0751	Eukaryota
BLAST	swissprot:CMC2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CMC2_HUMAN
BioCyc	ZFISH:ENSG00000004864-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000004864-MONOMER
COXPRESdb	10165	http://coxpresdb.jp/data/gene/10165.shtml
CleanEx	HS_SLC25A13	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC25A13
DOI	10.1002/humu.10022	http://dx.doi.org/10.1002/humu.10022
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/geno.1999.6006	http://dx.doi.org/10.1006/geno.1999.6006
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/9667	http://dx.doi.org/10.1038/9667
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1042/0264-6021:3450725	http://dx.doi.org/10.1042/0264-6021:3450725
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1074/mcp.O113.027870	http://dx.doi.org/10.1074/mcp.O113.027870
DOI	10.1093/emboj/20.18.5060	http://dx.doi.org/10.1093/emboj/20.18.5060
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DrugBank	DB00128	http://www.drugbank.ca/drugs/DB00128
EMBL	AC002450	http://www.ebi.ac.uk/ena/data/view/AC002450
EMBL	AC002540	http://www.ebi.ac.uk/ena/data/view/AC002540
EMBL	AC004458	http://www.ebi.ac.uk/ena/data/view/AC004458
EMBL	AC084368	http://www.ebi.ac.uk/ena/data/view/AC084368
EMBL	AC096775	http://www.ebi.ac.uk/ena/data/view/AC096775
EMBL	AF118838	http://www.ebi.ac.uk/ena/data/view/AF118838
EMBL	AH009104	http://www.ebi.ac.uk/ena/data/view/AH009104
EMBL	AJ496569	http://www.ebi.ac.uk/ena/data/view/AJ496569
EMBL	BC006566	http://www.ebi.ac.uk/ena/data/view/BC006566
EMBL	CH471091	http://www.ebi.ac.uk/ena/data/view/CH471091
EMBL	Y17571	http://www.ebi.ac.uk/ena/data/view/Y17571
Ensembl	ENST00000265631	http://www.ensembl.org/id/ENST00000265631
Ensembl	ENST00000416240	http://www.ensembl.org/id/ENST00000416240
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0005313	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005313
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0015172	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015172
GO_function	GO:0015183	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015183
GO_process	GO:0006094	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006094
GO_process	GO:0006754	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006754
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0015810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015810
GO_process	GO:0015813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015813
GO_process	GO:0043490	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043490
GO_process	GO:0045333	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045333
GO_process	GO:0051592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051592
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
Gene3D	1.10.238.10	http://www.cathdb.info/version/latest/superfamily/1.10.238.10
Gene3D	1.50.40.10	http://www.cathdb.info/version/latest/superfamily/1.50.40.10
GeneCards	SLC25A13	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC25A13
GeneID	10165	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10165
GeneTree	ENSGT00530000062944	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062944
H-InvDB	HIX0167840	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0167840
HGNC	HGNC:10983	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10983
HOGENOM	HOG000180633	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000180633&db=HOGENOM6
HOVERGEN	HBG005350	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG005350&db=HOVERGEN
HPA	HPA018997	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA018997
InParanoid	Q9UJS0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UJS0
IntAct	Q9UJS0	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9UJS0*
InterPro	IPR002048	http://www.ebi.ac.uk/interpro/entry/IPR002048
InterPro	IPR002067	http://www.ebi.ac.uk/interpro/entry/IPR002067
InterPro	IPR011992	http://www.ebi.ac.uk/interpro/entry/IPR011992
InterPro	IPR018108	http://www.ebi.ac.uk/interpro/entry/IPR018108
InterPro	IPR023395	http://www.ebi.ac.uk/interpro/entry/IPR023395
InterPro	IPR029658	http://www.ebi.ac.uk/interpro/entry/IPR029658
Jabion	10165	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10165
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00185	http://www.genome.jp/dbget-bin/www_bget?H00185
KEGG_Disease	H01398	http://www.genome.jp/dbget-bin/www_bget?H01398
KEGG_Gene	hsa:10165	http://www.genome.jp/dbget-bin/www_bget?hsa:10165
KEGG_Orthology	KO:K15105	http://www.genome.jp/dbget-bin/www_bget?KO:K15105
MIM	603471	http://www.ncbi.nlm.nih.gov/omim/603471
MIM	603859	http://www.ncbi.nlm.nih.gov/omim/603859
MIM	605814	http://www.ncbi.nlm.nih.gov/omim/605814
MINT	MINT-3081120	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3081120
OMA	CDEFEAV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CDEFEAV
Orphanet	247585	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=247585
Orphanet	247598	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=247598
OrthoDB	EOG091G08GT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08GT
PANTHER	PTHR24089:SF265	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24089:SF265
PDB	4P5W	http://www.ebi.ac.uk/pdbe-srv/view/entry/4P5W
PDBsum	4P5W	http://www.ebi.ac.uk/pdbsum/4P5W
PRINTS	PR00926	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00926
PROSITE	PS50222	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50222
PROSITE	PS50920	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50920
PSORT	swissprot:CMC2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CMC2_HUMAN
PSORT-B	swissprot:CMC2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CMC2_HUMAN
PSORT2	swissprot:CMC2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CMC2_HUMAN
Pfam	PF00153	http://pfam.xfam.org/family/PF00153
PharmGKB	PA35859	http://www.pharmgkb.org/do/serve?objId=PA35859&objCls=Gene
Phobius	swissprot:CMC2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CMC2_HUMAN
PhylomeDB	Q9UJS0	http://phylomedb.org/?seqid=Q9UJS0
ProteinModelPortal	Q9UJS0	http://www.proteinmodelportal.org/query/uniprot/Q9UJS0
PubMed	10369257	http://www.ncbi.nlm.nih.gov/pubmed/10369257
PubMed	10610724	http://www.ncbi.nlm.nih.gov/pubmed/10610724
PubMed	10642534	http://www.ncbi.nlm.nih.gov/pubmed/10642534
PubMed	11566871	http://www.ncbi.nlm.nih.gov/pubmed/11566871
PubMed	11793471	http://www.ncbi.nlm.nih.gov/pubmed/11793471
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24129315	http://www.ncbi.nlm.nih.gov/pubmed/24129315
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-1268020	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1268020
Reactome	R-HSA-70263	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-70263
RefSeq	NP_001153682	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001153682
RefSeq	NP_055066	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055066
SMR	Q9UJS0	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9UJS0
STRING	9606.ENSP00000400101	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000400101&targetmode=cogs
SUPFAM	SSF103506	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103506
SUPFAM	SSF47473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47473
TCDB	2.A.29.14	http://www.tcdb.org/search/result.php?tc=2.A.29.14
UCSC	uc003uof	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003uof&org=rat
UniGene	Hs.489190	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.489190
UniProtKB	CMC2_HUMAN	http://www.uniprot.org/uniprot/CMC2_HUMAN
UniProtKB-AC	Q9UJS0	http://www.uniprot.org/uniprot/Q9UJS0
charge	swissprot:CMC2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CMC2_HUMAN
eggNOG	ENOG410XNRM	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNRM
eggNOG	KOG0751	http://eggnogapi.embl.de/nog_data/html/tree/KOG0751
epestfind	swissprot:CMC2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CMC2_HUMAN
garnier	swissprot:CMC2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CMC2_HUMAN
helixturnhelix	swissprot:CMC2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CMC2_HUMAN
hmoment	swissprot:CMC2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CMC2_HUMAN
iep	swissprot:CMC2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CMC2_HUMAN
inforesidue	swissprot:CMC2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CMC2_HUMAN
neXtProt	NX_Q9UJS0	http://www.nextprot.org/db/entry/NX_Q9UJS0
octanol	swissprot:CMC2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CMC2_HUMAN
pepcoil	swissprot:CMC2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CMC2_HUMAN
pepdigest	swissprot:CMC2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CMC2_HUMAN
pepinfo	swissprot:CMC2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CMC2_HUMAN
pepnet	swissprot:CMC2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CMC2_HUMAN
pepstats	swissprot:CMC2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CMC2_HUMAN
pepwheel	swissprot:CMC2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CMC2_HUMAN
pepwindow	swissprot:CMC2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CMC2_HUMAN
sigcleave	swissprot:CMC2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CMC2_HUMAN
## Database	ID	URL or Descriptions
# AltName	CLCA2_HUMAN	Calcium-activated chloride channel family member 2
# AltName	CLCA2_HUMAN	Calcium-activated chloride channel protein 3
# BioGrid	114994	3
# ChiTaRS	CLCA2	human
# DOMAIN	CLCA2_HUMAN	The metalloprotease region is responsible for autoproteolytic processing. It can also cross-cleave other CLCA Substrates. {ECO 0000250|UniProtKB A8K7I4}. 
# Ensembl	ENST00000370565	ENSP00000359596; ENSG00000137975
# FUNCTION	CLCA2_HUMAN	Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4. {ECO 0000269|PubMed 10554024, ECO 0000269|PubMed 11320086, ECO 0000269|PubMed 11445004, ECO 0000269|PubMed 15707651, ECO 0000269|PubMed 16158324}. 
# GO_component	GO:0005576	extracellular region; IEA:UniProtKB-SubCell.
# GO_component	GO:0005634	nucleus; IDA:HPA.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0009925	basal plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0030054	cell junction; IDA:HPA.
# GO_function	GO:0004222	metalloendopeptidase activity; TAS:Reactome.
# GO_function	GO:0005229	intracellular calcium activated chloride channel activity; IEA:InterPro.
# GO_function	GO:0005254	chloride channel activity; TAS:ProtInc.
# GO_function	GO:0015276	ligand-gated ion channel activity; IEA:Ensembl.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007155	cell adhesion; IEA:UniProtKB-KW.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005576	extracellular region
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0008233	peptidase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007155	cell adhesion
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.410	-; 1.
# Genevisible	Q9UQC9	HS
# HGNC	HGNC:2016	CLCA2
# INDUCTION	CLCA2_HUMAN	Significantly down-regulated in breast and colorectal cancer. {ECO 0000269|PubMed 10554024, ECO 0000269|PubMed 11445004}. 
# InterPro	IPR002035	VWF_A
# InterPro	IPR004727	CLCA_chordata
# InterPro	IPR013642	CLCA
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04740	Olfactory transduction
# KEGG_Pathway	ko04972	Pancreatic secretion
# MIM	604003	gene
# Organism	CLCA2_HUMAN	Homo sapiens (Human)
# PROSITE	PS50234	VWFA
# PTM	CLCA2_HUMAN	N-glycosylated. {ECO 0000269|PubMed 10362588, ECO 0000269|PubMed 16873362}. 
# PTM	CLCA2_HUMAN	The 141 kDa mature form is autoproteolytically cleaved by the metalloprotease domain, producing a 109 kDa form and a 35 kDa form. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity. {ECO 0000250|UniProtKB A8K7I4}. 
# Pfam	PF08434	CLCA
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	CLCA2_HUMAN	Calcium-activated chloride channel regulator 2
# RecName	CLCA2_HUMAN	Calcium-activated chloride channel regulator 2, 109 kDa form
# RecName	CLCA2_HUMAN	Calcium-activated chloride channel regulator 2, 109 kDa form
# RecName	CLCA2_HUMAN	Calcium-activated chloride channel regulator 2, 35 kDa form
# RefSeq	NP_006527	NM_006536.6
# SIMILARITY	Belongs to the CLCR family. {ECO	0000305}. 
# SIMILARITY	Contains 1 VWFA domain. {ECO:0000255|PROSITE- ProRule	PRU00219}.
# SMART	SM00327	VWA
# SUBCELLULAR LOCATION	CLCA2_HUMAN	Calcium-activated chloride channel regulator 2, 109 kDa form  Secreted. Note=Remains associated to the 35 kDa form until an unidentified event triggers the release. 
# SUBCELLULAR LOCATION	CLCA2_HUMAN	Cell membrane; Single-pass type I membrane protein. Basal cell membrane; Single-pass type I membrane protein. Cell junction. 
# SUPFAM	SSF53300	SSF53300
# TIGRFAMs	TIGR00868	hCaCC
# TISSUE SPECIFICITY	CLCA2_HUMAN	Expressed in cornea, skin, vagina, esophagus, and larynx (at protein level). Expressed in trachea and mammary gland. Weakly expressed in testis and kidney. Highly expressed in corneal epithelium, colon and trachea. Moderately expressed in brain, urogenital organs, bladder, uterus and prostate. Highly expressed in tissues containing stratified epithelium including cornea, esophagus, larynx, skin and vagina than those tissues which contain only epithelial monolayers. Expressed in normal breast epithelium but not in breast cancer. Highly expressed during epithelial stratification. Expressed in endothelial cells of lung. Expressed selectively in endothelia of small pulmonary arteries, arterioles, and subpleural and interlobular venules. {ECO 0000269|PubMed 10362588, ECO 0000269|PubMed 10437792, ECO 0000269|PubMed 10554024, ECO 0000269|PubMed 11262615, ECO 0000269|PubMed 11320086, ECO 0000269|PubMed 14966209, ECO 0000269|PubMed 15707651, ECO 0000269|PubMed 16158324}. 
# UCSC	uc001dlr	human
# eggNOG	ENOG410IEPS	Eukaryota
# eggNOG	ENOG410XPSZ	LUCA
BLAST	swissprot:CLCA2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CLCA2_HUMAN
COXPRESdb	9635	http://coxpresdb.jp/data/gene/9635.shtml
CleanEx	HS_CLCA2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CLCA2
DOI	10.1007/s00441-005-0059-2	http://dx.doi.org/10.1007/s00441-005-0059-2
DOI	10.1016/S0014-5793(99)00891-1	http://dx.doi.org/10.1016/S0014-5793(99)00891-1
DOI	10.1016/j.acthis.2004.08.003	http://dx.doi.org/10.1016/j.acthis.2004.08.003
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M100478200	http://dx.doi.org/10.1074/jbc.M100478200
DOI	10.1074/jbc.M605919200	http://dx.doi.org/10.1074/jbc.M605919200
DOI	10.1076/ceyr.21.6.918.6983	http://dx.doi.org/10.1076/ceyr.21.6.918.6983
DOI	10.1089/10445490152122442	http://dx.doi.org/10.1089/10445490152122442
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1177/002215540405200313	http://dx.doi.org/10.1177/002215540405200313
EC_number	EC:3.4.-.- {ECO:0000250|UniProtKB:A8K7I4}	http://www.genome.jp/dbget-bin/www_bget?EC:3.4.-.- {ECO:0000250|UniProtKB:A8K7I4}
EMBL	AB026833	http://www.ebi.ac.uk/ena/data/view/AB026833
EMBL	AF043977	http://www.ebi.ac.uk/ena/data/view/AF043977
EMBL	AF127980	http://www.ebi.ac.uk/ena/data/view/AF127980
EMBL	AK290348	http://www.ebi.ac.uk/ena/data/view/AK290348
EMBL	BC041096	http://www.ebi.ac.uk/ena/data/view/BC041096
EMBL	CH471097	http://www.ebi.ac.uk/ena/data/view/CH471097
ENZYME	3.4.-.- {ECO:0000250|UniProtKB:A8K7I4}	http://enzyme.expasy.org/EC/3.4.-.- {ECO:0000250|UniProtKB:A8K7I4}
Ensembl	ENST00000370565	http://www.ensembl.org/id/ENST00000370565
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005576	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0009925	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009925
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_function	GO:0004222	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004222
GO_function	GO:0005229	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005229
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005576	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0008233	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.410	http://www.cathdb.info/version/latest/superfamily/3.40.50.410
GeneCards	CLCA2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CLCA2
GeneID	9635	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9635
GeneTree	ENSGT00390000004810	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000004810
HGNC	HGNC:2016	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2016
HOGENOM	HOG000015107	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000015107&db=HOGENOM6
HOVERGEN	HBG005560	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG005560&db=HOVERGEN
HPA	HPA047192	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA047192
InParanoid	Q9UQC9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UQC9
IntAct	Q9UQC9	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9UQC9*
IntEnz	3.4.-.- {ECO:0000250|UniProtKB:A8K7I4}	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.-.- {ECO:0000250|UniProtKB:A8K7I4}
InterPro	IPR002035	http://www.ebi.ac.uk/interpro/entry/IPR002035
InterPro	IPR004727	http://www.ebi.ac.uk/interpro/entry/IPR004727
InterPro	IPR013642	http://www.ebi.ac.uk/interpro/entry/IPR013642
Jabion	9635	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9635
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:9635	http://www.genome.jp/dbget-bin/www_bget?hsa:9635
KEGG_Orthology	KO:K05028	http://www.genome.jp/dbget-bin/www_bget?KO:K05028
KEGG_Pathway	ko04740	http://www.genome.jp/kegg-bin/show_pathway?ko04740
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
MIM	604003	http://www.ncbi.nlm.nih.gov/omim/604003
OMA	TNGPEHQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TNGPEHQ
OrthoDB	EOG091G09E6	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G09E6
PROSITE	PS50234	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50234
PSORT	swissprot:CLCA2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CLCA2_HUMAN
PSORT-B	swissprot:CLCA2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CLCA2_HUMAN
PSORT2	swissprot:CLCA2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CLCA2_HUMAN
Pfam	PF08434	http://pfam.xfam.org/family/PF08434
PharmGKB	PA26543	http://www.pharmgkb.org/do/serve?objId=PA26543&objCls=Gene
Phobius	swissprot:CLCA2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CLCA2_HUMAN
PhylomeDB	Q9UQC9	http://phylomedb.org/?seqid=Q9UQC9
ProteinModelPortal	Q9UQC9	http://www.proteinmodelportal.org/query/uniprot/Q9UQC9
PubMed	10362588	http://www.ncbi.nlm.nih.gov/pubmed/10362588
PubMed	10437792	http://www.ncbi.nlm.nih.gov/pubmed/10437792
PubMed	10554024	http://www.ncbi.nlm.nih.gov/pubmed/10554024
PubMed	11262615	http://www.ncbi.nlm.nih.gov/pubmed/11262615
PubMed	11320086	http://www.ncbi.nlm.nih.gov/pubmed/11320086
PubMed	11445004	http://www.ncbi.nlm.nih.gov/pubmed/11445004
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	14966209	http://www.ncbi.nlm.nih.gov/pubmed/14966209
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15707651	http://www.ncbi.nlm.nih.gov/pubmed/15707651
PubMed	16158324	http://www.ncbi.nlm.nih.gov/pubmed/16158324
PubMed	16873362	http://www.ncbi.nlm.nih.gov/pubmed/16873362
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_006527	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006527
SMART	SM00327	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00327
SMR	Q9UQC9	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9UQC9
STRING	9606.ENSP00000359596	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000359596&targetmode=cogs
SUPFAM	SSF53300	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53300
TIGRFAMs	TIGR00868	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00868
UCSC	uc001dlr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001dlr&org=rat
UniGene	Hs.241551	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.241551
UniProtKB	CLCA2_HUMAN	http://www.uniprot.org/uniprot/CLCA2_HUMAN
UniProtKB-AC	Q9UQC9	http://www.uniprot.org/uniprot/Q9UQC9
charge	swissprot:CLCA2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CLCA2_HUMAN
eggNOG	ENOG410IEPS	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IEPS
eggNOG	ENOG410XPSZ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPSZ
epestfind	swissprot:CLCA2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CLCA2_HUMAN
garnier	swissprot:CLCA2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CLCA2_HUMAN
helixturnhelix	swissprot:CLCA2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLCA2_HUMAN
hmoment	swissprot:CLCA2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CLCA2_HUMAN
iep	swissprot:CLCA2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CLCA2_HUMAN
inforesidue	swissprot:CLCA2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CLCA2_HUMAN
neXtProt	NX_Q9UQC9	http://www.nextprot.org/db/entry/NX_Q9UQC9
octanol	swissprot:CLCA2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CLCA2_HUMAN
pepcoil	swissprot:CLCA2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CLCA2_HUMAN
pepdigest	swissprot:CLCA2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CLCA2_HUMAN
pepinfo	swissprot:CLCA2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CLCA2_HUMAN
pepnet	swissprot:CLCA2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CLCA2_HUMAN
pepstats	swissprot:CLCA2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CLCA2_HUMAN
pepwheel	swissprot:CLCA2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CLCA2_HUMAN
pepwindow	swissprot:CLCA2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CLCA2_HUMAN
sigcleave	swissprot:CLCA2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CLCA2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	MTMR6_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y217-1; Sequence=Displayed; Name=2; IsoId=Q9Y217-2; Sequence=VSP_036614, VSP_036615; Note=No experimental confirmation available.; 
# BRENDA	3.1.3.95	2681
# BioGrid	114558	21
# CCDS	CCDS9313	-. [Q9Y217-1]
# ChiTaRS	MTMR6	human
# Ensembl	ENST00000381801	ENSP00000371221; ENSG00000139505. [Q9Y217-1]
# FUNCTION	MTMR6_HUMAN	Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells. {ECO 0000269|PubMed 15831468, ECO 0000269|PubMed 16847315}. 
# GO_component	GO:0005635	nuclear envelope; IEA:UniProtKB-SubCell.
# GO_component	GO:0005737	cytoplasm; IDA:LIFEdb.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_function	GO:0004438	phosphatidylinositol-3-phosphatase activity; TAS:Reactome.
# GO_function	GO:0004722	protein serine/threonine phosphatase activity; NAS:UniProtKB.
# GO_function	GO:0004725	protein tyrosine phosphatase activity; NAS:UniProtKB.
# GO_function	GO:0015269	calcium-activated potassium channel activity; IDA:UniProtKB.
# GO_function	GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; TAS:Reactome.
# GO_process	GO:0006470	protein dephosphorylation; NAS:UniProtKB.
# GO_process	GO:0006661	phosphatidylinositol biosynthetic process; TAS:Reactome.
# GO_process	GO:0046856	phosphatidylinositol dephosphorylation; IEA:InterPro.
# GOslim_component	GO:0005635	nuclear envelope
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_function	GO:0016791	phosphatase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0009058	biosynthetic process
# Gene3D	2.30.29.30	-; 1.
# Gene3D	3.90.190.10	-; 1.
# Genevisible	Q9Y217	HS
# HGNC	HGNC:7453	MTMR6
# INTERACTION	MTMR6_HUMAN	Q9Y2J4-4 AMOTL2; NbExp=3; IntAct=EBI-766064, EBI-10187270; Q96QG7 MTMR9; NbExp=8; IntAct=EBI-766064, EBI-744593; Q5JR59 MTUS2; NbExp=3; IntAct=EBI-766064, EBI-742948; Q13287 NMI; NbExp=3; IntAct=EBI-766064, EBI-372942; Q8WTW2 NMI; NbExp=3; IntAct=EBI-766064, EBI-10174268; P14373 TRIM27; NbExp=3; IntAct=EBI-766064, EBI-719493; 
# IntAct	Q9Y217	13
# InterPro	IPR003595	Tyr_Pase_cat
# InterPro	IPR010569	Myotubularin-like_Pase_dom
# InterPro	IPR011993	PH_dom-like
# InterPro	IPR016130	Tyr_Pase_AS
# InterPro	IPR029021	Prot-tyrosine_phosphatase-like
# InterPro	IPR030564	Myotubularin_fam
# InterPro	IPR030581	MTMR6
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00051	Fructose and mannose metabolism
# MIM	603561	gene
# Organism	MTMR6_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10807	PTHR10807
# PANTHER	PTHR10807:SF34	PTHR10807:SF34
# PDB	2YF0	X-ray; 2.65 A; A=1-505
# PROSITE	PS00383	TYR_PHOSPHATASE_1
# PROSITE	PS51339	PPASE_MYOTUBULARIN
# Pfam	PF06602	Myotub-related
# Proteomes	UP000005640	Chromosome 13
# Reactome	R-HSA-1660499	Synthesis of PIPs at the plasma membrane
# RecName	MTMR6_HUMAN	Myotubularin-related protein 6
# RefSeq	NP_004676	NM_004685.3. [Q9Y217-1]
# SIMILARITY	Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 myotubularin phosphatase domain. {ECO:0000255|PROSITE-ProRule	PRU00669}.
# SMART	SM00404	PTPc_motif
# SUBCELLULAR LOCATION	MTMR6_HUMAN	Nucleus envelope {ECO 0000269|PubMed 16787938}. 
# SUBUNIT	MTMR6_HUMAN	Interacts with ALKBH4, KCNN4, MTMR7, MTMR8 and MTMR9. {ECO 0000269|PubMed 12890864, ECO 0000269|PubMed 15831468, ECO 0000269|PubMed 16787938, ECO 0000269|PubMed 23145062}. 
# SUPFAM	SSF50729	SSF50729
# SUPFAM	SSF52799	SSF52799
# TISSUE SPECIFICITY	Expressed in CD4+ T-cells. {ECO:0000269|PubMed	16847315}. 
# TopDownProteomics	Q9Y217-1	-. [Q9Y217-1]
# UCSC	uc001uqf	human. [Q9Y217-1]
# eggNOG	ENOG410XPTU	LUCA
# eggNOG	KOG1089	Eukaryota
BLAST	swissprot:MTMR6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MTMR6_HUMAN
BioCyc	ZFISH:ENSG00000139505-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000139505-MONOMER
COG	COG0637	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0637
COG	COG2045	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2045
COXPRESdb	9107	http://coxpresdb.jp/data/gene/9107.shtml
CleanEx	HS_MTMR6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_MTMR6
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature02379	http://dx.doi.org/10.1038/nature02379
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.1333958100	http://dx.doi.org/10.1073/pnas.1333958100
DOI	10.1093/hmg/7.11.1703	http://dx.doi.org/10.1093/hmg/7.11.1703
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1128/MCB.00352-06	http://dx.doi.org/10.1128/MCB.00352-06
DOI	10.1128/MCB.25.9.3630-3638.2005	http://dx.doi.org/10.1128/MCB.25.9.3630-3638.2005
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.1242/jcs.03040	http://dx.doi.org/10.1242/jcs.03040
DOI	10.1371/journal.pone.0049045	http://dx.doi.org/10.1371/journal.pone.0049045
EC_number	EC:3.1.3.-	http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.-
EMBL	AF072928	http://www.ebi.ac.uk/ena/data/view/AF072928
EMBL	AF406619	http://www.ebi.ac.uk/ena/data/view/AF406619
EMBL	AK093237	http://www.ebi.ac.uk/ena/data/view/AK093237
EMBL	AK314587	http://www.ebi.ac.uk/ena/data/view/AK314587
EMBL	AL590787	http://www.ebi.ac.uk/ena/data/view/AL590787
EMBL	AL832017	http://www.ebi.ac.uk/ena/data/view/AL832017
EMBL	BC040012	http://www.ebi.ac.uk/ena/data/view/BC040012
ENZYME	3.1.3.-	http://enzyme.expasy.org/EC/3.1.3.-
Ensembl	ENST00000381801	http://www.ensembl.org/id/ENST00000381801
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_function	GO:0004438	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004438
GO_function	GO:0004722	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004722
GO_function	GO:0004725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004725
GO_function	GO:0015269	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015269
GO_function	GO:0052629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052629
GO_process	GO:0006470	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006470
GO_process	GO:0006661	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006661
GO_process	GO:0046856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046856
GOslim_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_function	GO:0016791	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
Gene3D	2.30.29.30	http://www.cathdb.info/version/latest/superfamily/2.30.29.30
Gene3D	3.90.190.10	http://www.cathdb.info/version/latest/superfamily/3.90.190.10
GeneCards	MTMR6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=MTMR6
GeneID	9107	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9107
GeneTree	ENSGT00760000118832	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118832
H-InvDB	HIX0011183	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0011183
H-InvDB	HIX0171878	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0171878
HGNC	HGNC:7453	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:7453
HOVERGEN	HBG000220	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000220&db=HOVERGEN
HPA	HPA034778	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA034778
InParanoid	Q9Y217	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y217
IntAct	Q9Y217	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9Y217*
IntEnz	3.1.3	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3
InterPro	IPR003595	http://www.ebi.ac.uk/interpro/entry/IPR003595
InterPro	IPR010569	http://www.ebi.ac.uk/interpro/entry/IPR010569
InterPro	IPR011993	http://www.ebi.ac.uk/interpro/entry/IPR011993
InterPro	IPR016130	http://www.ebi.ac.uk/interpro/entry/IPR016130
InterPro	IPR029021	http://www.ebi.ac.uk/interpro/entry/IPR029021
InterPro	IPR030564	http://www.ebi.ac.uk/interpro/entry/IPR030564
InterPro	IPR030581	http://www.ebi.ac.uk/interpro/entry/IPR030581
Jabion	9107	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9107
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:9107	http://www.genome.jp/dbget-bin/www_bget?hsa:9107
KEGG_Orthology	KO:K01112	http://www.genome.jp/dbget-bin/www_bget?KO:K01112
KEGG_Pathway	ko00051	http://www.genome.jp/kegg-bin/show_pathway?ko00051
KEGG_Reaction	rn:R00118	http://www.genome.jp/dbget-bin/www_bget?rn:R00118
KEGG_Reaction	rn:R00872	http://www.genome.jp/dbget-bin/www_bget?rn:R00872
KEGG_Reaction	rn:R02706	http://www.genome.jp/dbget-bin/www_bget?rn:R02706
MIM	603561	http://www.ncbi.nlm.nih.gov/omim/603561
MINT	MINT-2822863	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-2822863
OMA	IKFWRGM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IKFWRGM
OrthoDB	EOG091G02LA	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02LA
PANTHER	PTHR10807	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10807
PANTHER	PTHR10807:SF34	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10807:SF34
PDB	2YF0	http://www.ebi.ac.uk/pdbe-srv/view/entry/2YF0
PDBsum	2YF0	http://www.ebi.ac.uk/pdbsum/2YF0
PROSITE	PS00383	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00383
PROSITE	PS51339	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51339
PSORT	swissprot:MTMR6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MTMR6_HUMAN
PSORT-B	swissprot:MTMR6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MTMR6_HUMAN
PSORT2	swissprot:MTMR6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MTMR6_HUMAN
Pfam	PF06602	http://pfam.xfam.org/family/PF06602
PharmGKB	PA31256	http://www.pharmgkb.org/do/serve?objId=PA31256&objCls=Gene
Phobius	swissprot:MTMR6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MTMR6_HUMAN
PhylomeDB	Q9Y217	http://phylomedb.org/?seqid=Q9Y217
ProteinModelPortal	Q9Y217	http://www.proteinmodelportal.org/query/uniprot/Q9Y217
PubMed	12890864	http://www.ncbi.nlm.nih.gov/pubmed/12890864
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15057823	http://www.ncbi.nlm.nih.gov/pubmed/15057823
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15831468	http://www.ncbi.nlm.nih.gov/pubmed/15831468
PubMed	16787938	http://www.ncbi.nlm.nih.gov/pubmed/16787938
PubMed	16847315	http://www.ncbi.nlm.nih.gov/pubmed/16847315
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	23145062	http://www.ncbi.nlm.nih.gov/pubmed/23145062
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	9736772	http://www.ncbi.nlm.nih.gov/pubmed/9736772
Reactome	R-HSA-1660499	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1660499
RefSeq	NP_004676	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004676
SMART	SM00404	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00404
SMR	Q9Y217	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9Y217
STRING	9606.ENSP00000371221	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000371221&targetmode=cogs
STRING	COG0637	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0637&targetmode=cogs
STRING	COG2045	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2045&targetmode=cogs
SUPFAM	SSF50729	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50729
SUPFAM	SSF52799	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52799
UCSC	uc001uqf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001uqf&org=rat
UniGene	Hs.643702	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.643702
UniProtKB	MTMR6_HUMAN	http://www.uniprot.org/uniprot/MTMR6_HUMAN
UniProtKB-AC	Q9Y217	http://www.uniprot.org/uniprot/Q9Y217
charge	swissprot:MTMR6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MTMR6_HUMAN
eggNOG	ENOG410XPTU	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPTU
eggNOG	KOG1089	http://eggnogapi.embl.de/nog_data/html/tree/KOG1089
epestfind	swissprot:MTMR6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MTMR6_HUMAN
garnier	swissprot:MTMR6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MTMR6_HUMAN
helixturnhelix	swissprot:MTMR6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MTMR6_HUMAN
hmoment	swissprot:MTMR6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MTMR6_HUMAN
iep	swissprot:MTMR6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MTMR6_HUMAN
inforesidue	swissprot:MTMR6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MTMR6_HUMAN
neXtProt	NX_Q9Y217	http://www.nextprot.org/db/entry/NX_Q9Y217
octanol	swissprot:MTMR6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MTMR6_HUMAN
pepcoil	swissprot:MTMR6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MTMR6_HUMAN
pepdigest	swissprot:MTMR6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MTMR6_HUMAN
pepinfo	swissprot:MTMR6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MTMR6_HUMAN
pepnet	swissprot:MTMR6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MTMR6_HUMAN
pepstats	swissprot:MTMR6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MTMR6_HUMAN
pepwheel	swissprot:MTMR6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MTMR6_HUMAN
pepwindow	swissprot:MTMR6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MTMR6_HUMAN
sigcleave	swissprot:MTMR6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MTMR6_HUMAN
## Database	ID	URL or Descriptions
# AltName	S15A3_HUMAN	Osteoclast transporter
# AltName	S15A3_HUMAN	Peptide transporter 3
# AltName	S15A3_HUMAN	Peptide/histidine transporter 2
# BioGrid	119447	8
# CDD	cd06174	MFS
# Ensembl	ENST00000227880	ENSP00000227880; ENSG00000110446
# ExpressionAtlas	Q8IY34	baseline and differential
# FUNCTION	S15A3_HUMAN	Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity). {ECO 0000250}. 
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_function	S15A3_HUMAN	GO 0015333 peptide proton symporter activity; TAS Reactome.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0015031	protein transport; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q8IY34	HS
# HGNC	HGNC:18068	SLC15A3
# IntAct	Q8IY34	3
# InterPro	IPR000109	POT_fam
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02001	Solute carrier family
# MIM	610408	gene
# Organism	S15A3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11654	PTHR11654; 2
# Pfam	PF00854	PTR2
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-427975	Proton/oligopeptide cotransporters
# RecName	S15A3_HUMAN	Solute carrier family 15 member 3
# RefSeq	NP_057666	NM_016582.2
# SIMILARITY	Belongs to the PTR2/POT transporter (TC 2.A.17) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S15A3_HUMAN	Lysosome membrane {ECO 0000269|PubMed 17897319}; Multi-pass membrane protein {ECO 0000269|PubMed 17897319}. 
# SUPFAM	SSF103473	SSF103473; 3
# TCDB	2.A.17.3	the proton-dependent oligopeptide transporter (pot/ptr) family
# UCSC	uc001nqn	human
# eggNOG	COG3104	LUCA
# eggNOG	KOG1237	Eukaryota
BLAST	swissprot:S15A3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S15A3_HUMAN
COXPRESdb	51296	http://coxpresdb.jp/data/gene/51296.shtml
CleanEx	HS_SLC15A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC15A3
DIP	DIP-60838N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-60838N
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1600-0854.2007.00643.x	http://dx.doi.org/10.1111/j.1600-0854.2007.00643.x
EMBL	AB020598	http://www.ebi.ac.uk/ena/data/view/AB020598
EMBL	AF135600	http://www.ebi.ac.uk/ena/data/view/AF135600
EMBL	AP003721	http://www.ebi.ac.uk/ena/data/view/AP003721
EMBL	BC037974	http://www.ebi.ac.uk/ena/data/view/BC037974
Ensembl	ENST00000227880	http://www.ensembl.org/id/ENST00000227880
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0015333	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015333
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0015031	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC15A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC15A3
GeneID	51296	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51296
GeneTree	ENSGT00530000062961	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062961
HGNC	HGNC:18068	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18068
HOGENOM	HOG000143436	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000143436&db=HOGENOM6
HOVERGEN	HBG108431	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108431&db=HOVERGEN
HPA	HPA047880	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA047880
HPA	HPA057642	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA057642
InParanoid	Q8IY34	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8IY34
IntAct	Q8IY34	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8IY34*
InterPro	IPR000109	http://www.ebi.ac.uk/interpro/entry/IPR000109
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	51296	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=51296
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:51296	http://www.genome.jp/dbget-bin/www_bget?hsa:51296
KEGG_Orthology	KO:K14638	http://www.genome.jp/dbget-bin/www_bget?KO:K14638
MIM	610408	http://www.ncbi.nlm.nih.gov/omim/610408
OMA	HYIHRNE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HYIHRNE
OrthoDB	EOG091G0GF9	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0GF9
PANTHER	PTHR11654	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11654
PSORT	swissprot:S15A3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S15A3_HUMAN
PSORT-B	swissprot:S15A3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S15A3_HUMAN
PSORT2	swissprot:S15A3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S15A3_HUMAN
Pfam	PF00854	http://pfam.xfam.org/family/PF00854
PharmGKB	PA134919658	http://www.pharmgkb.org/do/serve?objId=PA134919658&objCls=Gene
Phobius	swissprot:S15A3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S15A3_HUMAN
PhylomeDB	Q8IY34	http://phylomedb.org/?seqid=Q8IY34
ProteinModelPortal	Q8IY34	http://www.proteinmodelportal.org/query/uniprot/Q8IY34
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	17897319	http://www.ncbi.nlm.nih.gov/pubmed/17897319
Reactome	R-HSA-427975	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-427975
RefSeq	NP_057666	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_057666
STRING	9606.ENSP00000227880	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000227880&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.17.3	http://www.tcdb.org/search/result.php?tc=2.A.17.3
UCSC	uc001nqn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001nqn&org=rat
UniGene	Hs.237856	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.237856
UniProtKB	S15A3_HUMAN	http://www.uniprot.org/uniprot/S15A3_HUMAN
UniProtKB-AC	Q8IY34	http://www.uniprot.org/uniprot/Q8IY34
charge	swissprot:S15A3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S15A3_HUMAN
eggNOG	COG3104	http://eggnogapi.embl.de/nog_data/html/tree/COG3104
eggNOG	KOG1237	http://eggnogapi.embl.de/nog_data/html/tree/KOG1237
epestfind	swissprot:S15A3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S15A3_HUMAN
garnier	swissprot:S15A3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S15A3_HUMAN
helixturnhelix	swissprot:S15A3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S15A3_HUMAN
hmoment	swissprot:S15A3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S15A3_HUMAN
iep	swissprot:S15A3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S15A3_HUMAN
inforesidue	swissprot:S15A3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S15A3_HUMAN
neXtProt	NX_Q8IY34	http://www.nextprot.org/db/entry/NX_Q8IY34
octanol	swissprot:S15A3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S15A3_HUMAN
pepcoil	swissprot:S15A3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S15A3_HUMAN
pepdigest	swissprot:S15A3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S15A3_HUMAN
pepinfo	swissprot:S15A3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S15A3_HUMAN
pepnet	swissprot:S15A3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S15A3_HUMAN
pepstats	swissprot:S15A3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S15A3_HUMAN
pepwheel	swissprot:S15A3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S15A3_HUMAN
pepwindow	swissprot:S15A3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S15A3_HUMAN
sigcleave	swissprot:S15A3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S15A3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SC6A4_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P31645-1; Sequence=Displayed; Name=2; IsoId=P31645-2; Sequence=VSP_046553; 
# AltName	SC6A4_HUMAN	5HT transporter
# AltName	SC6A4_HUMAN	Solute carrier family 6 member 4
# BioGrid	112423	5
# CCDS	CCDS11256	-. [P31645-1]
# DrugBank	DB00176	Fluvoxamine
# DrugBank	DB00182	Amphetamine
# DrugBank	DB00191	Phentermine
# DrugBank	DB00193	Tramadol
# DrugBank	DB00215	Citalopram
# DrugBank	DB00285	Venlafaxine
# DrugBank	DB00289	Atomoxetine
# DrugBank	DB00321	Amitriptyline
# DrugBank	DB00344	Protriptyline
# DrugBank	DB00370	Mirtazapine
# DrugBank	DB00408	Loxapine
# DrugBank	DB00422	Methylphenidate
# DrugBank	DB00454	Pethidine
# DrugBank	DB00458	Imipramine
# DrugBank	DB00472	Fluoxetine
# DrugBank	DB00476	Duloxetine
# DrugBank	DB00514	Dextromethorphan
# DrugBank	DB00540	Nortriptyline
# DrugBank	DB00543	Amoxapine
# DrugBank	DB00579	Mazindol
# DrugBank	DB00656	Trazodone
# DrugBank	DB00661	Verapamil
# DrugBank	DB00715	Paroxetine
# DrugBank	DB00726	Trimipramine
# DrugBank	DB00805	Minaprine
# DrugBank	DB00852	Pseudoephedrine
# DrugBank	DB00907	Cocaine
# DrugBank	DB00988	Dopamine
# DrugBank	DB01104	Sertraline
# DrugBank	DB01105	Sibutramine
# DrugBank	DB01114	Chlorphenamine
# DrugBank	DB01142	Doxepin
# DrugBank	DB01149	Nefazodone
# DrugBank	DB01151	Desipramine
# DrugBank	DB01175	Escitalopram
# DrugBank	DB01191	Dexfenfluramine
# DrugBank	DB01242	Clomipramine
# DrugBank	DB01363	Ephedra
# DrugBank	DB01577	Methamphetamine
# DrugBank	DB04896	Milnacipran
# DrugBank	DB06148	Mianserin
# DrugBank	DB06204	Tapentadol
# DrugBank	DB06684	Vilazodone
# DrugBank	DB06700	Desvenlafaxine
# DrugBank	DB06701	Dexmethylphenidate
# DrugBank	DB08918	Levomilnacipran
# DrugBank	DB09016	Butriptyline
# DrugBank	DB09068	Vortioxetine
# Ensembl	ENST00000261707	ENSP00000261707; ENSG00000108576. [P31645-1]
# Ensembl	ENST00000401766	ENSP00000385822; ENSG00000108576. [P31645-1]
# ExpressionAtlas	P31645	baseline and differential
# FUNCTION	SC6A4_HUMAN	Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. {ECO 0000269|PubMed 17506858, ECO 0000269|PubMed 18227069, ECO 0000269|PubMed 19270731, ECO 0000269|PubMed 27049939}. 
# GO_component	GO:0005829	cytosol; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IC:UniProtKB.
# GO_component	GO:0010008	endosome membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0012505	endomembrane system; IDA:UniProtKB.
# GO_component	GO:0043005	neuron projection; IBA:GO_Central.
# GO_component	GO:0045121	membrane raft; IDA:UniProtKB.
# GO_component	GO:0098793	presynapse; IEA:GOC.
# GO_function	GO:0008504	monoamine transmembrane transporter activity; IDA:MGI.
# GO_function	GO:0015222	serotonin transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0017137	Rab GTPase binding; IPI:UniProtKB.
# GO_function	GO:0019811	cocaine binding; IEA:Ensembl.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_function	GO:0051015	actin filament binding; ISS:UniProtKB.
# GO_function	SC6A4_HUMAN	GO 0005335 serotonin sodium symporter activity; IDA UniProtKB.
# GO_process	GO:0001666	response to hypoxia; IEA:Ensembl.
# GO_process	GO:0006837	serotonin transport; IDA:UniProtKB.
# GO_process	GO:0007268	chemical synaptic transmission; IBA:GO_Central.
# GO_process	GO:0007584	response to nutrient; IEA:Ensembl.
# GO_process	GO:0007613	memory; IEA:Ensembl.
# GO_process	GO:0007623	circadian rhythm; IEA:Ensembl.
# GO_process	GO:0009636	response to toxic substance; IDA:UniProtKB.
# GO_process	GO:0010628	positive regulation of gene expression; IEA:Ensembl.
# GO_process	GO:0015844	monoamine transport; IDA:MGI.
# GO_process	GO:0021794	thalamus development; IMP:UniProtKB.
# GO_process	GO:0021941	negative regulation of cerebellar granule cell precursor proliferation; IEA:Ensembl.
# GO_process	GO:0032227	negative regulation of synaptic transmission, dopaminergic; IEA:Ensembl.
# GO_process	GO:0032355	response to estradiol; IEA:Ensembl.
# GO_process	GO:0035176	social behavior; ISS:BHF-UCL.
# GO_process	GO:0042310	vasoconstriction; IEA:Ensembl.
# GO_process	GO:0042493	response to drug; IEA:Ensembl.
# GO_process	GO:0042713	sperm ejaculation; IEA:Ensembl.
# GO_process	GO:0045665	negative regulation of neuron differentiation; IEA:Ensembl.
# GO_process	GO:0045787	positive regulation of cell cycle; IEA:Ensembl.
# GO_process	GO:0046621	negative regulation of organ growth; ISS:BHF-UCL.
# GO_process	GO:0048854	brain morphogenesis; ISS:BHF-UCL.
# GO_process	GO:0051259	protein oligomerization; ISS:UniProtKB.
# GO_process	GO:0051260	protein homooligomerization; IEA:Ensembl.
# GO_process	GO:0051610	serotonin uptake; IDA:UniProtKB.
# GO_process	GO:0071300	cellular response to retinoic acid; IEA:Ensembl.
# GO_process	GO:0071321	cellular response to cGMP; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0008092	cytoskeletal protein binding
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0003013	circulatory system process
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# Genevisible	P31645	HS
# HGNC	HGNC:11050	SLC6A4
# INDUCTION	SC6A4_HUMAN	Down-regulated when plasma serotonin is elevated. {ECO 0000269|PubMed 18227069, ECO 0000269|PubMed 19270731}. 
# IntAct	P31645	2
# InterPro	IPR000175	Na/ntran_symport
# InterPro	IPR013086	Na/ntran_symport_serotonin_N
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H01450	[Mental and behavioural disorders] Obsessive-compulsive disorder (OCD)
# KEGG_Pathway	ko04726	Serotonergic synapse
# MIM	103780	phenotype
# MIM	164230	phenotype
# MIM	182138	gene
# MISCELLANEOUS	SC6A4_HUMAN	This protein is the target of psychomotor stimulants such as amphetamines or cocaine. 
# Organism	SC6A4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11616	PTHR11616; 2
# PDB	5I6X	X-ray; 3.14 A; A=76-618
# PDB	5I6Z	X-ray; 4.53 A; A=76-618
# PDB	5I71	X-ray; 3.15 A; A=76-618
# PDB	5I73	X-ray; 3.24 A; A=76-618
# PDB	5I74	X-ray; 3.40 A; A=76-618
# PDB	5I75	X-ray; 3.49 A; A=76-618
# PIR	A47398	A47398
# POLYMORPHISM	A polymorphism in the promoter region (5-HTT gene- linked polymorphic region, 5-HTTLPR) is located approximately 1 kb upstream of the transcription initiation site and is composed of 16 repeat elements. The polymorphism consists of a 44-bp insertion or deletion involving repeat elements 6 to 8. The short allele is associated with lower transcriptional efficiency of the promoter compared with the long allele. Over half of the Caucasian population has a short allele. Individuals with one or two copies of the short allele exhibit more depressive symptoms, diagnosable depression and suicidality in relation to stressful life events than individuals homozygous for the long allele. {ECO:0000269|PubMed	12869766}. 
# POLYMORPHISM	Genetic variations in SLC6A4 determine the genetic susceptibility to alcoholism [MIM:103780]. {ECO	0000269|PubMed:15635638}. 
# POLYMORPHISM	SC6A4_HUMAN	The polymorphism Val-425 seems to be linked to a susceptibility to obsessive-compulsive disorder (OCD) [MIM 164230]. {ECO 0000269|PubMed 12869649, ECO 0000269|PubMed 14593431, ECO 0000269|PubMed 17913921}. 
# PRINTS	PR00176	NANEUSMPORT
# PRINTS	PR01203	5HTTRANSPORT
# PROSITE	PS00610	NA_NEUROTRAN_SYMP_1
# PROSITE	PS00754	NA_NEUROTRAN_SYMP_2
# PROSITE	PS50267	NA_NEUROTRAN_SYMP_3
# PTM	SC6A4_HUMAN	Glycosylated; modification with sialylated N-glycans is a requirement for transporters to associate with each other and to function as homooligomeric forms. {ECO 0000250}. 
# PTM	SC6A4_HUMAN	Phosphorylation at Thr-276 increases 5-HT uptake and is required for cGMP-mediated SERT regulation. Phosphorylation upon PKC stimulation modifies the SERT distribution and density in the membrane, and diminishes the uptake capacity. {ECO 0000269|PubMed 17913921, ECO 0000269|PubMed 19270731, ECO 0000269|PubMed 21992875}. 
# Pfam	PF00209	SNF
# Pfam	PF03491	5HT_transport_N
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-380615	Serotonin clearance from the synaptic cleft
# RecName	SC6A4_HUMAN	Sodium-dependent serotonin transporter
# RefSeq	NP_001036	NM_001045.5. [P31645-1]
# SIMILARITY	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	SC6A4_HUMAN	Cell membrane {ECO 0000269|PubMed 16870614, ECO 0000269|PubMed 17506858, ECO 0000269|PubMed 18227069, ECO 0000269|PubMed 19270731, ECO 0000269|PubMed 27049939}; Multi- pass membrane protein {ECO 0000250|UniProtKB Q7K4Y6, ECO 0000269|PubMed 27049939}. Endomembrane system {ECO 0000269|PubMed 16870614}; Multi-pass membrane protein {ECO 0000255}. Endosome membrane {ECO 0000269|PubMed 16870614, ECO 0000269|PubMed 18227069}; Multi-pass membrane protein {ECO 0000255}. Note=Could be part of recycling endosomes (PubMed 18227069, PubMed 16870614). Density of transporter molecules on the plasma membrane is itself regulated by STX1A (By similarity). Density of transporter molecules on the plasma membrane is also regulated by serotonin (PubMed 17506858) (PubMed 18227069). {ECO 0000250|UniProtKB P31652, ECO 0000269|PubMed 16870614, ECO 0000269|PubMed 17506858, ECO 0000269|PubMed 18227069}. 
# SUBUNIT	SC6A4_HUMAN	Monomer or homooligomer (By similarity). Interacts with TGFB1I1. Interacts (via sialylated form) with MYH9. Interacts with SEC23A, SEC24C and PATJ. Interacts with NOS1; the interaction may diminish the cell surface localization of SERT in the brain and, correspondingly, reduce serotonin reuptake. Interacts with filamentous actin and STX1A (By similarity). Interacts (via C- terminus) with VIM. Interacts (via C-terminus) with SCAMP2; the interaction is direct and retains transporter molecules intracellularly. Interacts with RAB4 (GTP-bound form); the interaction retains transporter molecules intracellularly. {ECO 0000250, ECO 0000269|PubMed 16803896, ECO 0000269|PubMed 16870614, ECO 0000269|PubMed 18227069, ECO 0000269|PubMed 19270731}. 
# TCDB	2.A.22.1:the neurotransmitter	sodium symporter (nss) family
# TISSUE SPECIFICITY	Expressed in platelets (at protein level). {ECO:0000269|PubMed	17506858}. 
# UCSC	uc002hey	human. [P31645-1]
# WEB RESOURCE	SC6A4_HUMAN	Name=NIEHS-SNPs; URL="http //egp.gs.washington.edu/data/slc6a4/";
# WEB RESOURCE	SC6A4_HUMAN	Name=Protein Spotlight; Note=Love, love, love... -Issue 123 of November 2010; URL="http //web.expasy.org/spotlight/back_issues/123"; 
# WEB RESOURCE	SC6A4_HUMAN	Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http //shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=SLC6A4"; 
# WEB RESOURCE	SC6A4_HUMAN	Name=Wikipedia; Note=Serotonin transporter entry; URL="https //en.wikipedia.org/wiki/Serotonin_transporter"; 
# eggNOG	COG0733	LUCA
# eggNOG	KOG3659	Eukaryota
BLAST	swissprot:SC6A4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SC6A4_HUMAN
BioCyc	ZFISH:ENSG00000108576-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000108576-MONOMER
COXPRESdb	6532	http://coxpresdb.jp/data/gene/6532.shtml
CleanEx	HS_HTT	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_HTT
CleanEx	HS_SLC6A4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC6A4
DOI	10.1002/ajmg.b.30132	http://dx.doi.org/10.1002/ajmg.b.30132
DOI	10.1007/BF01244919	http://dx.doi.org/10.1007/BF01244919
DOI	10.1038/10290	http://dx.doi.org/10.1038/10290
DOI	10.1038/nature17629	http://dx.doi.org/10.1038/nature17629
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.mp.4001365	http://dx.doi.org/10.1038/sj.mp.4001365
DOI	10.1073/pnas.90.6.2542	http://dx.doi.org/10.1073/pnas.90.6.2542
DOI	10.1074/jbc.M602848200	http://dx.doi.org/10.1074/jbc.M602848200
DOI	10.1074/jbc.M603877200	http://dx.doi.org/10.1074/jbc.M603877200
DOI	10.1074/jbc.M706367200	http://dx.doi.org/10.1074/jbc.M706367200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1471-4159.1993.tb03522.x	http://dx.doi.org/10.1111/j.1471-4159.1993.tb03522.x
DOI	10.1111/j.1471-4159.2007.04542.x	http://dx.doi.org/10.1111/j.1471-4159.2007.04542.x
DOI	10.1124/mol.111.073171	http://dx.doi.org/10.1124/mol.111.073171
DOI	10.1124/mol.64.2.440	http://dx.doi.org/10.1124/mol.64.2.440
DOI	10.1126/science.1083968	http://dx.doi.org/10.1126/science.1083968
DOI	10.1371/journal.pone.0004730	http://dx.doi.org/10.1371/journal.pone.0004730
DOI	10.1523/JNEUROSCI.0034-07.2007	http://dx.doi.org/10.1523/JNEUROSCI.0034-07.2007
DrugBank	DB00176	http://www.drugbank.ca/drugs/DB00176
DrugBank	DB00182	http://www.drugbank.ca/drugs/DB00182
DrugBank	DB00191	http://www.drugbank.ca/drugs/DB00191
DrugBank	DB00193	http://www.drugbank.ca/drugs/DB00193
DrugBank	DB00215	http://www.drugbank.ca/drugs/DB00215
DrugBank	DB00285	http://www.drugbank.ca/drugs/DB00285
DrugBank	DB00289	http://www.drugbank.ca/drugs/DB00289
DrugBank	DB00321	http://www.drugbank.ca/drugs/DB00321
DrugBank	DB00344	http://www.drugbank.ca/drugs/DB00344
DrugBank	DB00370	http://www.drugbank.ca/drugs/DB00370
DrugBank	DB00408	http://www.drugbank.ca/drugs/DB00408
DrugBank	DB00422	http://www.drugbank.ca/drugs/DB00422
DrugBank	DB00454	http://www.drugbank.ca/drugs/DB00454
DrugBank	DB00458	http://www.drugbank.ca/drugs/DB00458
DrugBank	DB00472	http://www.drugbank.ca/drugs/DB00472
DrugBank	DB00476	http://www.drugbank.ca/drugs/DB00476
DrugBank	DB00514	http://www.drugbank.ca/drugs/DB00514
DrugBank	DB00540	http://www.drugbank.ca/drugs/DB00540
DrugBank	DB00543	http://www.drugbank.ca/drugs/DB00543
DrugBank	DB00579	http://www.drugbank.ca/drugs/DB00579
DrugBank	DB00656	http://www.drugbank.ca/drugs/DB00656
DrugBank	DB00661	http://www.drugbank.ca/drugs/DB00661
DrugBank	DB00715	http://www.drugbank.ca/drugs/DB00715
DrugBank	DB00726	http://www.drugbank.ca/drugs/DB00726
DrugBank	DB00805	http://www.drugbank.ca/drugs/DB00805
DrugBank	DB00852	http://www.drugbank.ca/drugs/DB00852
DrugBank	DB00907	http://www.drugbank.ca/drugs/DB00907
DrugBank	DB00988	http://www.drugbank.ca/drugs/DB00988
DrugBank	DB01104	http://www.drugbank.ca/drugs/DB01104
DrugBank	DB01105	http://www.drugbank.ca/drugs/DB01105
DrugBank	DB01114	http://www.drugbank.ca/drugs/DB01114
DrugBank	DB01142	http://www.drugbank.ca/drugs/DB01142
DrugBank	DB01149	http://www.drugbank.ca/drugs/DB01149
DrugBank	DB01151	http://www.drugbank.ca/drugs/DB01151
DrugBank	DB01175	http://www.drugbank.ca/drugs/DB01175
DrugBank	DB01191	http://www.drugbank.ca/drugs/DB01191
DrugBank	DB01242	http://www.drugbank.ca/drugs/DB01242
DrugBank	DB01363	http://www.drugbank.ca/drugs/DB01363
DrugBank	DB01577	http://www.drugbank.ca/drugs/DB01577
DrugBank	DB04896	http://www.drugbank.ca/drugs/DB04896
DrugBank	DB06148	http://www.drugbank.ca/drugs/DB06148
DrugBank	DB06204	http://www.drugbank.ca/drugs/DB06204
DrugBank	DB06684	http://www.drugbank.ca/drugs/DB06684
DrugBank	DB06700	http://www.drugbank.ca/drugs/DB06700
DrugBank	DB06701	http://www.drugbank.ca/drugs/DB06701
DrugBank	DB08918	http://www.drugbank.ca/drugs/DB08918
DrugBank	DB09016	http://www.drugbank.ca/drugs/DB09016
DrugBank	DB09068	http://www.drugbank.ca/drugs/DB09068
EMBL	AK308014	http://www.ebi.ac.uk/ena/data/view/AK308014
EMBL	AY902473	http://www.ebi.ac.uk/ena/data/view/AY902473
EMBL	BC069484	http://www.ebi.ac.uk/ena/data/view/BC069484
EMBL	EU099989	http://www.ebi.ac.uk/ena/data/view/EU099989
EMBL	L05568	http://www.ebi.ac.uk/ena/data/view/L05568
EMBL	U79746	http://www.ebi.ac.uk/ena/data/view/U79746
EMBL	X70697	http://www.ebi.ac.uk/ena/data/view/X70697
Ensembl	ENST00000261707	http://www.ensembl.org/id/ENST00000261707
Ensembl	ENST00000401766	http://www.ensembl.org/id/ENST00000401766
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0010008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010008
GO_component	GO:0012505	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0012505
GO_component	GO:0043005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043005
GO_component	GO:0045121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045121
GO_component	GO:0098793	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098793
GO_function	GO:0005335	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005335
GO_function	GO:0008504	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008504
GO_function	GO:0015222	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015222
GO_function	GO:0017137	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017137
GO_function	GO:0019811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019811
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_function	GO:0051015	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051015
GO_process	GO:0001666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001666
GO_process	GO:0006837	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006837
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007584	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007584
GO_process	GO:0007613	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007613
GO_process	GO:0007623	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007623
GO_process	GO:0009636	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009636
GO_process	GO:0010628	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010628
GO_process	GO:0015844	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015844
GO_process	GO:0021794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021794
GO_process	GO:0021941	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021941
GO_process	GO:0032227	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032227
GO_process	GO:0032355	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032355
GO_process	GO:0035176	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035176
GO_process	GO:0042310	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042310
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0042713	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042713
GO_process	GO:0045665	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045665
GO_process	GO:0045787	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045787
GO_process	GO:0046621	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046621
GO_process	GO:0048854	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048854
GO_process	GO:0051259	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051259
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:0051610	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051610
GO_process	GO:0071300	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071300
GO_process	GO:0071321	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071321
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0008092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0003013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003013
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	SLC6A4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC6A4
GeneID	6532	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6532
GeneTree	ENSGT00760000118857	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118857
HGNC	HGNC:11050	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11050
HOGENOM	HOG000116406	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116406&db=HOGENOM6
HOVERGEN	HBG071421	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG071421&db=HOVERGEN
HPA	HPA054723	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA054723
InParanoid	P31645	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31645
IntAct	P31645	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31645*
InterPro	IPR000175	http://www.ebi.ac.uk/interpro/entry/IPR000175
InterPro	IPR013086	http://www.ebi.ac.uk/interpro/entry/IPR013086
Jabion	6532	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6532
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H01450	http://www.genome.jp/dbget-bin/www_bget?H01450
KEGG_Gene	hsa:6532	http://www.genome.jp/dbget-bin/www_bget?hsa:6532
KEGG_Orthology	KO:K05037	http://www.genome.jp/dbget-bin/www_bget?KO:K05037
KEGG_Pathway	ko04726	http://www.genome.jp/kegg-bin/show_pathway?ko04726
MIM	103780	http://www.ncbi.nlm.nih.gov/omim/103780
MIM	164230	http://www.ncbi.nlm.nih.gov/omim/164230
MIM	182138	http://www.ncbi.nlm.nih.gov/omim/182138
MINT	MINT-577123	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-577123
OMA	CRDVKEM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CRDVKEM
OrthoDB	EOG091G08PX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08PX
PANTHER	PTHR11616	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11616
PDB	5I6X	http://www.ebi.ac.uk/pdbe-srv/view/entry/5I6X
PDB	5I6Z	http://www.ebi.ac.uk/pdbe-srv/view/entry/5I6Z
PDB	5I71	http://www.ebi.ac.uk/pdbe-srv/view/entry/5I71
PDB	5I73	http://www.ebi.ac.uk/pdbe-srv/view/entry/5I73
PDB	5I74	http://www.ebi.ac.uk/pdbe-srv/view/entry/5I74
PDB	5I75	http://www.ebi.ac.uk/pdbe-srv/view/entry/5I75
PDBsum	5I6X	http://www.ebi.ac.uk/pdbsum/5I6X
PDBsum	5I6Z	http://www.ebi.ac.uk/pdbsum/5I6Z
PDBsum	5I71	http://www.ebi.ac.uk/pdbsum/5I71
PDBsum	5I73	http://www.ebi.ac.uk/pdbsum/5I73
PDBsum	5I74	http://www.ebi.ac.uk/pdbsum/5I74
PDBsum	5I75	http://www.ebi.ac.uk/pdbsum/5I75
PRINTS	PR00176	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00176
PRINTS	PR01203	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01203
PROSITE	PS00610	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00610
PROSITE	PS00754	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00754
PROSITE	PS50267	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50267
PSORT	swissprot:SC6A4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SC6A4_HUMAN
PSORT-B	swissprot:SC6A4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SC6A4_HUMAN
PSORT2	swissprot:SC6A4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SC6A4_HUMAN
Pfam	PF00209	http://pfam.xfam.org/family/PF00209
Pfam	PF03491	http://pfam.xfam.org/family/PF03491
PharmGKB	PA312	http://www.pharmgkb.org/do/serve?objId=PA312&objCls=Gene
Phobius	swissprot:SC6A4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SC6A4_HUMAN
PhylomeDB	P31645	http://phylomedb.org/?seqid=P31645
ProteinModelPortal	P31645	http://www.proteinmodelportal.org/query/uniprot/P31645
PubMed	10391209	http://www.ncbi.nlm.nih.gov/pubmed/10391209
PubMed	12869649	http://www.ncbi.nlm.nih.gov/pubmed/12869649
PubMed	12869766	http://www.ncbi.nlm.nih.gov/pubmed/12869766
PubMed	14593431	http://www.ncbi.nlm.nih.gov/pubmed/14593431
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15635638	http://www.ncbi.nlm.nih.gov/pubmed/15635638
PubMed	16601320	http://www.ncbi.nlm.nih.gov/pubmed/16601320
PubMed	16803896	http://www.ncbi.nlm.nih.gov/pubmed/16803896
PubMed	16870614	http://www.ncbi.nlm.nih.gov/pubmed/16870614
PubMed	17506858	http://www.ncbi.nlm.nih.gov/pubmed/17506858
PubMed	17913921	http://www.ncbi.nlm.nih.gov/pubmed/17913921
PubMed	18227069	http://www.ncbi.nlm.nih.gov/pubmed/18227069
PubMed	19270731	http://www.ncbi.nlm.nih.gov/pubmed/19270731
PubMed	21992875	http://www.ncbi.nlm.nih.gov/pubmed/21992875
PubMed	27049939	http://www.ncbi.nlm.nih.gov/pubmed/27049939
PubMed	7681602	http://www.ncbi.nlm.nih.gov/pubmed/7681602
PubMed	7684072	http://www.ncbi.nlm.nih.gov/pubmed/7684072
PubMed	8452685	http://www.ncbi.nlm.nih.gov/pubmed/8452685
Reactome	R-HSA-380615	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-380615
RefSeq	NP_001036	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001036
SMR	P31645	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31645
STRING	9606.ENSP00000261707	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000261707&targetmode=cogs
TCDB	2.A.22.1	http://www.tcdb.org/search/result.php?tc=2.A.22.1
UCSC	uc002hey	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002hey&org=rat
UniGene	Hs.134662	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.134662
UniGene	Hs.29792	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.29792
UniProtKB	SC6A4_HUMAN	http://www.uniprot.org/uniprot/SC6A4_HUMAN
UniProtKB-AC	P31645	http://www.uniprot.org/uniprot/P31645
charge	swissprot:SC6A4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SC6A4_HUMAN
eggNOG	COG0733	http://eggnogapi.embl.de/nog_data/html/tree/COG0733
eggNOG	KOG3659	http://eggnogapi.embl.de/nog_data/html/tree/KOG3659
epestfind	swissprot:SC6A4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SC6A4_HUMAN
garnier	swissprot:SC6A4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SC6A4_HUMAN
helixturnhelix	swissprot:SC6A4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SC6A4_HUMAN
hmoment	swissprot:SC6A4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SC6A4_HUMAN
iep	swissprot:SC6A4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SC6A4_HUMAN
inforesidue	swissprot:SC6A4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SC6A4_HUMAN
neXtProt	NX_P31645	http://www.nextprot.org/db/entry/NX_P31645
octanol	swissprot:SC6A4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SC6A4_HUMAN
pepcoil	swissprot:SC6A4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SC6A4_HUMAN
pepdigest	swissprot:SC6A4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SC6A4_HUMAN
pepinfo	swissprot:SC6A4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SC6A4_HUMAN
pepnet	swissprot:SC6A4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SC6A4_HUMAN
pepstats	swissprot:SC6A4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SC6A4_HUMAN
pepwheel	swissprot:SC6A4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SC6A4_HUMAN
pepwindow	swissprot:SC6A4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SC6A4_HUMAN
sigcleave	swissprot:SC6A4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SC6A4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SO1C1_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9NYB5-1; Sequence=Displayed; Name=2; IsoId=Q9NYB5-2; Sequence=VSP_042882; Note=No experimental confirmation available.; Name=3; IsoId=Q9NYB5-3; Sequence=VSP_045279; Note=Ref.3 (BAH14027) sequence is in conflict in position  660 T->S. {ECO 0000305}; Name=4; IsoId=Q9NYB5-4; Sequence=VSP_045278, VSP_045279; Note=No experimental confirmation available. Ref.3 (BAH11737) sequence is in conflict in position  559 S->F. {ECO 0000305}; 
# AltName	SO1C1_HUMAN	Organic anion transporter F
# AltName	SO1C1_HUMAN	Organic anion transporter polypeptide-related protein 5
# AltName	SO1C1_HUMAN	Organic anion-transporting polypeptide 14
# AltName	SO1C1_HUMAN	Solute carrier family 21 member 14
# AltName	SO1C1_HUMAN	Thyroxine transporter
# CCDS	CCDS53757	-. [Q9NYB5-3]
# CCDS	CCDS53758	-. [Q9NYB5-2]
# CCDS	CCDS53759	-. [Q9NYB5-4]
# CCDS	CCDS8683	-. [Q9NYB5-1]
# CDD	cd06174	MFS
# DrugBank	DB00252	Phenytoin
# DrugBank	DB00279	Liothyronine
# DrugBank	DB00286	Conjugated Estrogens
# DrugBank	DB00390	Digoxin
# DrugBank	DB00451	Levothyroxine
# DrugBank	DB00509	Dextrothyroxine
# DrugBank	DB00563	Methotrexate
# DrugBank	DB00586	Diclofenac
# DrugBank	DB00783	Estradiol
# DrugBank	DB00917	Dinoprostone
# DrugBank	DB00939	Meclofenamic acid
# DrugBank	DB01032	Probenecid
# DrugBank	DB01092	Ouabain
# DrugBank	DB01583	Liotrix
# Ensembl	ENST00000266509	ENSP00000266509; ENSG00000139155. [Q9NYB5-1]
# Ensembl	ENST00000540354	ENSP00000438665; ENSG00000139155. [Q9NYB5-2]
# Ensembl	ENST00000545102	ENSP00000444527; ENSG00000139155. [Q9NYB5-4]
# Ensembl	ENST00000545604	ENSP00000444149; ENSG00000139155. [Q9NYB5-3]
# ExpressionAtlas	Q9NYB5	baseline and differential
# FUNCTION	SO1C1_HUMAN	Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a signifiant role in regulating T4 flux into and out of the brain (By similarity). {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0015125	bile acid transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015347	sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015349	thyroid hormone transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0008206	bile acid metabolic process; IBA:GO_Central.
# GO_process	GO:0043252	sodium-independent organic anion transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0044281	small molecule metabolic process
# Genevisible	Q9NYB5	HS
# HGNC	HGNC:13819	SLCO1C1
# InterPro	IPR002350	Kazal_dom
# InterPro	IPR004156	OA_transporter
# InterPro	IPR020846	MFS_dom
# InterPro	IPR030764	OATP1C1
# KEGG_Brite	ko02001	Solute carrier family
# MIM	613389	gene
# Organism	SO1C1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11388	PTHR11388
# PANTHER	PTHR11388:SF99	PTHR11388:SF99
# PROSITE	PS50850	MFS
# PROSITE	PS51465	KAZAL_2
# Pfam	PF03137	OATP
# Pfam	PF07648	Kazal_2
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-879518	Transport of organic anions
# RecName	SO1C1_HUMAN	Solute carrier organic anion transporter family member 1C1
# RefSeq	NP_001139416	NM_001145944.1. [Q9NYB5-4]
# RefSeq	NP_001139417	NM_001145945.1. [Q9NYB5-2]
# RefSeq	NP_001139418	NM_001145946.1. [Q9NYB5-3]
# RefSeq	NP_059131	NM_017435.4. [Q9NYB5-1]
# RefSeq	XP_005253451	XM_005253394.2. [Q9NYB5-1]
# RefSeq	XP_005253453	XM_005253396.2. [Q9NYB5-4]
# RefSeq	XP_011519011	XM_011520709.2. [Q9NYB5-4]
# RefSeq	XP_016874973	XM_017019484.1. [Q9NYB5-4]
# RefSeq	XP_016874974	XM_017019485.1. [Q9NYB5-4]
# SIMILARITY	Belongs to the organo anion transporter (TC 2.A.60) family. {ECO	0000305}. 
# SIMILARITY	Contains 1 Kazal-like domain. {ECO:0000255|PROSITE- ProRule	PRU00798}.
# SUBCELLULAR LOCATION	SO1C1_HUMAN	Cell membrane {ECO 0000269|PubMed 18687783}; Multi-pass membrane protein {ECO 0000269|PubMed 18687783}. Note=Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus (By similarity). {ECO 0000250}. 
# SUPFAM	SSF103473	SSF103473; 4
# TCDB	2.A.60.1.15	the organo anion transporter (oat) family
# TIGRFAMs	TIGR00805	oat
# TISSUE SPECIFICITY	Highly expressed in brain and in Leydig cells in testis. Detected in many brain regions with the exception of pons and cerebellum. Not strongly enriched in cerebral microvessels. {ECO:0000269|PubMed	18687783}. 
# UCSC	uc001rei	human. [Q9NYB5-1]
# eggNOG	ENOG410XRSF	LUCA
# eggNOG	KOG3626	Eukaryota
BLAST	swissprot:SO1C1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SO1C1_HUMAN
BioCyc	ZFISH:ENSG00000139155-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000139155-MONOMER
COXPRESdb	53919	http://coxpresdb.jp/data/gene/53919.shtml
CleanEx	HS_SLCO1C1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLCO1C1
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.1210/en.2008-0378	http://dx.doi.org/10.1210/en.2008-0378
DOI	10.1210/me.2001-0309	http://dx.doi.org/10.1210/me.2001-0309
DrugBank	DB00252	http://www.drugbank.ca/drugs/DB00252
DrugBank	DB00279	http://www.drugbank.ca/drugs/DB00279
DrugBank	DB00286	http://www.drugbank.ca/drugs/DB00286
DrugBank	DB00390	http://www.drugbank.ca/drugs/DB00390
DrugBank	DB00451	http://www.drugbank.ca/drugs/DB00451
DrugBank	DB00509	http://www.drugbank.ca/drugs/DB00509
DrugBank	DB00563	http://www.drugbank.ca/drugs/DB00563
DrugBank	DB00586	http://www.drugbank.ca/drugs/DB00586
DrugBank	DB00783	http://www.drugbank.ca/drugs/DB00783
DrugBank	DB00917	http://www.drugbank.ca/drugs/DB00917
DrugBank	DB00939	http://www.drugbank.ca/drugs/DB00939
DrugBank	DB01032	http://www.drugbank.ca/drugs/DB01032
DrugBank	DB01092	http://www.drugbank.ca/drugs/DB01092
DrugBank	DB01583	http://www.drugbank.ca/drugs/DB01583
EMBL	AC092491	http://www.ebi.ac.uk/ena/data/view/AC092491
EMBL	AF205076	http://www.ebi.ac.uk/ena/data/view/AF205076
EMBL	AF260704	http://www.ebi.ac.uk/ena/data/view/AF260704
EMBL	AK294333	http://www.ebi.ac.uk/ena/data/view/AK294333
EMBL	AK296236	http://www.ebi.ac.uk/ena/data/view/AK296236
EMBL	AK303713	http://www.ebi.ac.uk/ena/data/view/AK303713
EMBL	AL834209	http://www.ebi.ac.uk/ena/data/view/AL834209
EMBL	BC022461	http://www.ebi.ac.uk/ena/data/view/BC022461
Ensembl	ENST00000266509	http://www.ensembl.org/id/ENST00000266509
Ensembl	ENST00000540354	http://www.ensembl.org/id/ENST00000540354
Ensembl	ENST00000545102	http://www.ensembl.org/id/ENST00000545102
Ensembl	ENST00000545604	http://www.ensembl.org/id/ENST00000545604
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0015125	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015125
GO_function	GO:0015347	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015347
GO_function	GO:0015349	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015349
GO_process	GO:0008206	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008206
GO_process	GO:0043252	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043252
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GeneCards	SLCO1C1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLCO1C1
GeneID	53919	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=53919
GeneTree	ENSGT00760000119014	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119014
HGNC	HGNC:13819	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13819
HOGENOM	HOG000231269	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231269&db=HOGENOM6
HOVERGEN	HBG063896	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG063896&db=HOVERGEN
HPA	CAB022193	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB022193
InParanoid	Q9NYB5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NYB5
InterPro	IPR002350	http://www.ebi.ac.uk/interpro/entry/IPR002350
InterPro	IPR004156	http://www.ebi.ac.uk/interpro/entry/IPR004156
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
InterPro	IPR030764	http://www.ebi.ac.uk/interpro/entry/IPR030764
Jabion	53919	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=53919
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:53919	http://www.genome.jp/dbget-bin/www_bget?hsa:53919
KEGG_Orthology	KO:K08747	http://www.genome.jp/dbget-bin/www_bget?KO:K08747
MIM	613389	http://www.ncbi.nlm.nih.gov/omim/613389
OMA	YWPGKET	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YWPGKET
OrthoDB	EOG091G08QD	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08QD
PANTHER	PTHR11388	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11388
PANTHER	PTHR11388:SF99	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11388:SF99
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PROSITE	PS51465	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51465
PSORT	swissprot:SO1C1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SO1C1_HUMAN
PSORT-B	swissprot:SO1C1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SO1C1_HUMAN
PSORT2	swissprot:SO1C1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SO1C1_HUMAN
Pfam	PF03137	http://pfam.xfam.org/family/PF03137
Pfam	PF07648	http://pfam.xfam.org/family/PF07648
PharmGKB	PA37815	http://www.pharmgkb.org/do/serve?objId=PA37815&objCls=Gene
Phobius	swissprot:SO1C1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SO1C1_HUMAN
PhylomeDB	Q9NYB5	http://phylomedb.org/?seqid=Q9NYB5
ProteinModelPortal	Q9NYB5	http://www.proteinmodelportal.org/query/uniprot/Q9NYB5
PubMed	12351693	http://www.ncbi.nlm.nih.gov/pubmed/12351693
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18687783	http://www.ncbi.nlm.nih.gov/pubmed/18687783
Reactome	R-HSA-879518	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-879518
RefSeq	NP_001139416	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001139416
RefSeq	NP_001139417	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001139417
RefSeq	NP_001139418	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001139418
RefSeq	NP_059131	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_059131
RefSeq	XP_005253451	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005253451
RefSeq	XP_005253453	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005253453
RefSeq	XP_011519011	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011519011
RefSeq	XP_016874973	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016874973
RefSeq	XP_016874974	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016874974
STRING	9606.ENSP00000370964	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000370964&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.60.1.15	http://www.tcdb.org/search/result.php?tc=2.A.60.1.15
TIGRFAMs	TIGR00805	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00805
UCSC	uc001rei	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001rei&org=rat
UniGene	Hs.47261	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.47261
UniProtKB	SO1C1_HUMAN	http://www.uniprot.org/uniprot/SO1C1_HUMAN
UniProtKB-AC	Q9NYB5	http://www.uniprot.org/uniprot/Q9NYB5
charge	swissprot:SO1C1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SO1C1_HUMAN
eggNOG	ENOG410XRSF	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRSF
eggNOG	KOG3626	http://eggnogapi.embl.de/nog_data/html/tree/KOG3626
epestfind	swissprot:SO1C1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SO1C1_HUMAN
garnier	swissprot:SO1C1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SO1C1_HUMAN
helixturnhelix	swissprot:SO1C1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SO1C1_HUMAN
hmoment	swissprot:SO1C1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SO1C1_HUMAN
iep	swissprot:SO1C1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SO1C1_HUMAN
inforesidue	swissprot:SO1C1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SO1C1_HUMAN
neXtProt	NX_Q9NYB5	http://www.nextprot.org/db/entry/NX_Q9NYB5
octanol	swissprot:SO1C1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SO1C1_HUMAN
pepcoil	swissprot:SO1C1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SO1C1_HUMAN
pepdigest	swissprot:SO1C1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SO1C1_HUMAN
pepinfo	swissprot:SO1C1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SO1C1_HUMAN
pepnet	swissprot:SO1C1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SO1C1_HUMAN
pepstats	swissprot:SO1C1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SO1C1_HUMAN
pepwheel	swissprot:SO1C1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SO1C1_HUMAN
pepwindow	swissprot:SO1C1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SO1C1_HUMAN
sigcleave	swissprot:SO1C1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SO1C1_HUMAN
## Database	ID	URL or Descriptions
# AltName	CAHM1_HUMAN	Protein FAM26C
# ENZYME REGULATION	Inhibited by Gd(3+), Ruthenium Red, and Zn(2+) and partially inhibited by 2-aminoethoxydiphenyl borate. {ECO:0000269|PubMed	22711817}. 
# Ensembl	ENST00000329905	ENSP00000329926; ENSG00000185933
# FUNCTION	CAHM1_HUMAN	Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes. Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways. Acts both as a voltage-gated and calcium-activated ion channel  mediates neuronal excitability in response to changes in extracellular Ca(2+) concentration. Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca(2+), Na(+) and K(+), as well as permeation of monovalent anions. Acts as an activator of the ERK1 and ERK2 cascade. Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum. May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner. {ECO 0000269|PubMed 18585350, ECO 0000269|PubMed 21574960, ECO 0000269|PubMed 22711817, ECO 0000269|PubMed 23300080, ECO 0000269|PubMed 23345406}. 
# GO_component	GO:0005789	endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_function	GO:0005227	calcium activated cation channel activity; IDA:UniProtKB.
# GO_function	GO:0005244	voltage-gated ion channel activity; IDA:UniProtKB.
# GO_function	GO:0005245	voltage-gated calcium channel activity; IEA:Ensembl.
# GO_process	GO:0006812	cation transport; IDA:UniProtKB.
# GO_process	GO:0015867	ATP transport; ISS:UniProtKB.
# GO_process	GO:0034765	regulation of ion transmembrane transport; IDA:UniProtKB.
# GO_process	GO:0050913	sensory perception of bitter taste; ISS:UniProtKB.
# GO_process	GO:0050916	sensory perception of sweet taste; ISS:UniProtKB.
# GO_process	GO:0050917	sensory perception of umami taste; ISS:UniProtKB.
# GO_process	GO:0051260	protein homooligomerization; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# Genevisible	Q8IU99	HS
# HGNC	HGNC:23494	CALHM1
# INTERACTION	CAHM1_HUMAN	Self; NbExp=3; IntAct=EBI-1790341, EBI-1790341; 
# InterPro	IPR029568	CALHM1
# InterPro	IPR029569	FAM26
# MIM	612234	gene
# Organism	CAHM1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR32261	PTHR32261; 2
# PANTHER	PTHR32261:SF2	PTHR32261:SF2; 2
# POLYMORPHISM	CAHM1_HUMAN	Leu-86 causes a dysregulation of Ca(2+) homeostasis and amyloid precursor protein (APP) metabolism and has been suggested to be a risk factor for the development of Alzheimer disease (PubMed 18585350, PubMed 20061624, PubMed 20164592). However, this association with Alzheimer disease could not be confirmed in a number of studies performed in different populations (PubMed 19472444, PubMed 19070563, PubMed 19191331, PubMed 19191332, PubMed 19545933, PubMed 19655363, PubMed 21378601). According to a meta-analysis study, Leu-86 is likely not a genetic determinant of Alzheimer disease but may modulate age of onset by interacting with the effect of the APOE*4 allele of the APOE gene (PubMed 20847397). {ECO 0000269|PubMed 18585350, ECO 0000269|PubMed 19070563, ECO 0000269|PubMed 19191331, ECO 0000269|PubMed 19191332, ECO 0000269|PubMed 19472444, ECO 0000269|PubMed 19545933, ECO 0000269|PubMed 19655363, ECO 0000269|PubMed 20061624, ECO 0000269|PubMed 20164592, ECO 0000269|PubMed 20847397, ECO 0000269|PubMed 21378601}. 
# Pfam	PF14798	Ca_hom_mod
# Proteomes	UP000005640	Chromosome 10
# RecName	CAHM1_HUMAN	Calcium homeostasis modulator protein 1
# RefSeq	NP_001001412	NM_001001412.3
# SIMILARITY	Belongs to the FAM26 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	CAHM1_HUMAN	Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Colocalizes with HSPA5 at the endoplasmic reticulum. 
# SUBUNIT	CAHM1_HUMAN	Homohexamer. {ECO 0000269|PubMed 18585350, ECO 0000269|PubMed 23300080}. 
# TCDB	1.A.84.1	the calcium homeostasis modulator ca(2+) channel (calhm-c) family
# TISSUE SPECIFICITY	CAHM1_HUMAN	Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells. Specifically expressed in circumvallate taste bud cells. {ECO 0000269|PubMed 18585350, ECO 0000269|PubMed 19997627}. 
# UCSC	uc001kxe	human
# eggNOG	ENOG410IG7G	Eukaryota
# eggNOG	ENOG410YNIM	LUCA
BLAST	swissprot:CAHM1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CAHM1_HUMAN
BioCyc	ZFISH:G66-32619-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32619-MONOMER
COXPRESdb	255022	http://coxpresdb.jp/data/gene/255022.shtml
CleanEx	HS_CALHM1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CALHM1
DOI	10.1002/ajmg.b.31014	http://dx.doi.org/10.1002/ajmg.b.31014
DOI	10.1002/humu.20989	http://dx.doi.org/10.1002/humu.20989
DOI	10.1002/humu.20990	http://dx.doi.org/10.1002/humu.20990
DOI	10.1016/j.cell.2008.05.048	http://dx.doi.org/10.1016/j.cell.2008.05.048
DOI	10.1016/j.cell.2008.11.030	http://dx.doi.org/10.1016/j.cell.2008.11.030
DOI	10.1016/j.neurobiolaging.2009.05.008	http://dx.doi.org/10.1016/j.neurobiolaging.2009.05.008
DOI	10.1038/nature02462	http://dx.doi.org/10.1038/nature02462
DOI	10.1042/BJ20110479	http://dx.doi.org/10.1042/BJ20110479
DOI	10.1073/pnas.1204023109	http://dx.doi.org/10.1073/pnas.1204023109
DOI	10.1074/jbc.M112.409789	http://dx.doi.org/10.1074/jbc.M112.409789
DOI	10.1097/YPG.0b013e3283457bcc	http://dx.doi.org/10.1097/YPG.0b013e3283457bcc
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1469-1809.2009.00509.x	http://dx.doi.org/10.1111/j.1469-1809.2009.00509.x
DOI	10.1242/jcs.117135	http://dx.doi.org/10.1242/jcs.117135
DOI	10.1371/journal.pone.0007682	http://dx.doi.org/10.1371/journal.pone.0007682
DOI	10.3233/JAD-2010-100933	http://dx.doi.org/10.3233/JAD-2010-100933
DOI	10.3233/JAD-2010-1207	http://dx.doi.org/10.3233/JAD-2010-1207
DOI	10.3233/JAD-2010-1357	http://dx.doi.org/10.3233/JAD-2010-1357
EMBL	AL139339	http://www.ebi.ac.uk/ena/data/view/AL139339
EMBL	BC036193	http://www.ebi.ac.uk/ena/data/view/BC036193
EMBL	BC036208	http://www.ebi.ac.uk/ena/data/view/BC036208
Ensembl	ENST00000329905	http://www.ensembl.org/id/ENST00000329905
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005227	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005227
GO_function	GO:0005244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005244
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_process	GO:0006812	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006812
GO_process	GO:0015867	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015867
GO_process	GO:0034765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034765
GO_process	GO:0050913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050913
GO_process	GO:0050916	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050916
GO_process	GO:0050917	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050917
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	CALHM1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CALHM1
GeneID	255022	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=255022
GeneTree	ENSGT00530000062796	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062796
H-InvDB	HIX0201512	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0201512
HGNC	HGNC:23494	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:23494
HOGENOM	HOG000111295	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000111295&db=HOGENOM6
HOVERGEN	HBG096020	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG096020&db=HOVERGEN
HPA	HPA018317	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA018317
InParanoid	Q8IU99	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8IU99
InterPro	IPR029568	http://www.ebi.ac.uk/interpro/entry/IPR029568
InterPro	IPR029569	http://www.ebi.ac.uk/interpro/entry/IPR029569
Jabion	255022	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=255022
KEGG_Gene	hsa:255022	http://www.genome.jp/dbget-bin/www_bget?hsa:255022
MIM	612234	http://www.ncbi.nlm.nih.gov/omim/612234
OMA	MNNNVSM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MNNNVSM
OrthoDB	EOG091G09L8	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G09L8
PANTHER	PTHR32261	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32261
PANTHER	PTHR32261:SF2	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32261:SF2
PSORT	swissprot:CAHM1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CAHM1_HUMAN
PSORT-B	swissprot:CAHM1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CAHM1_HUMAN
PSORT2	swissprot:CAHM1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CAHM1_HUMAN
Pfam	PF14798	http://pfam.xfam.org/family/PF14798
PharmGKB	PA162380954	http://www.pharmgkb.org/do/serve?objId=PA162380954&objCls=Gene
Phobius	swissprot:CAHM1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CAHM1_HUMAN
PhylomeDB	Q8IU99	http://phylomedb.org/?seqid=Q8IU99
ProteinModelPortal	Q8IU99	http://www.proteinmodelportal.org/query/uniprot/Q8IU99
PubMed	15164054	http://www.ncbi.nlm.nih.gov/pubmed/15164054
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18585350	http://www.ncbi.nlm.nih.gov/pubmed/18585350
PubMed	19070563	http://www.ncbi.nlm.nih.gov/pubmed/19070563
PubMed	19191331	http://www.ncbi.nlm.nih.gov/pubmed/19191331
PubMed	19191332	http://www.ncbi.nlm.nih.gov/pubmed/19191332
PubMed	19472444	http://www.ncbi.nlm.nih.gov/pubmed/19472444
PubMed	19545933	http://www.ncbi.nlm.nih.gov/pubmed/19545933
PubMed	19655363	http://www.ncbi.nlm.nih.gov/pubmed/19655363
PubMed	19997627	http://www.ncbi.nlm.nih.gov/pubmed/19997627
PubMed	20061624	http://www.ncbi.nlm.nih.gov/pubmed/20061624
PubMed	20164592	http://www.ncbi.nlm.nih.gov/pubmed/20164592
PubMed	20847397	http://www.ncbi.nlm.nih.gov/pubmed/20847397
PubMed	21378601	http://www.ncbi.nlm.nih.gov/pubmed/21378601
PubMed	21574960	http://www.ncbi.nlm.nih.gov/pubmed/21574960
PubMed	22711817	http://www.ncbi.nlm.nih.gov/pubmed/22711817
PubMed	23300080	http://www.ncbi.nlm.nih.gov/pubmed/23300080
PubMed	23345406	http://www.ncbi.nlm.nih.gov/pubmed/23345406
RefSeq	NP_001001412	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001001412
STRING	9606.ENSP00000329926	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000329926&targetmode=cogs
TCDB	1.A.84.1	http://www.tcdb.org/search/result.php?tc=1.A.84.1
UCSC	uc001kxe	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001kxe&org=rat
UniGene	Hs.680365	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.680365
UniProtKB	CAHM1_HUMAN	http://www.uniprot.org/uniprot/CAHM1_HUMAN
UniProtKB-AC	Q8IU99	http://www.uniprot.org/uniprot/Q8IU99
charge	swissprot:CAHM1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CAHM1_HUMAN
eggNOG	ENOG410IG7G	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IG7G
eggNOG	ENOG410YNIM	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YNIM
epestfind	swissprot:CAHM1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CAHM1_HUMAN
garnier	swissprot:CAHM1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CAHM1_HUMAN
helixturnhelix	swissprot:CAHM1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CAHM1_HUMAN
hmoment	swissprot:CAHM1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CAHM1_HUMAN
iep	swissprot:CAHM1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CAHM1_HUMAN
inforesidue	swissprot:CAHM1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CAHM1_HUMAN
neXtProt	NX_Q8IU99	http://www.nextprot.org/db/entry/NX_Q8IU99
octanol	swissprot:CAHM1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CAHM1_HUMAN
pepcoil	swissprot:CAHM1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CAHM1_HUMAN
pepdigest	swissprot:CAHM1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CAHM1_HUMAN
pepinfo	swissprot:CAHM1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CAHM1_HUMAN
pepnet	swissprot:CAHM1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CAHM1_HUMAN
pepstats	swissprot:CAHM1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CAHM1_HUMAN
pepwheel	swissprot:CAHM1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CAHM1_HUMAN
pepwindow	swissprot:CAHM1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CAHM1_HUMAN
sigcleave	swissprot:CAHM1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CAHM1_HUMAN
## Database	ID	URL or Descriptions
# AltName	S22AP_HUMAN	Organic anion transporter UST6
# CDD	cd06174	MFS
# Ensembl	ENST00000306494	ENSP00000307443; ENSG00000196600
# ExpressionAtlas	Q6T423	baseline and differential
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0005452	inorganic anion exchanger activity; IBA:GO_Central.
# GO_function	GO:0015347	sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0043252	sodium-independent organic anion transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# HGNC	HGNC:32935	SLC22A25
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	610792	gene
# Organism	S22AP_HUMAN	Homo sapiens (Human)
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 11
# RecName	S22AP_HUMAN	Solute carrier family 22 member 25
# RefSeq	NP_955384	NM_199352.3
# RefSeq	XP_016873176	XM_017017687.1
# SIMILARITY	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S22AP_HUMAN	Membrane {ECO 0000255}; Multi-pass membrane protein {ECO 0000255}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.19.33	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	Expressed exclusively in liver in both embryo and adult. {ECO:0000269|PubMed	15054140}. 
# UCSC	uc001nwr	human
# eggNOG	COG0477	LUCA
# eggNOG	KOG0255	Eukaryota
BLAST	swissprot:S22AP_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S22AP_HUMAN
BioCyc	ZFISH:G66-32719-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32719-MONOMER
COXPRESdb	387601	http://coxpresdb.jp/data/gene/387601.shtml
CleanEx	HS_SLC22A25	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC22A25
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1152/physiolgenomics.00014.2004	http://dx.doi.org/10.1152/physiolgenomics.00014.2004
EMBL	AP001880	http://www.ebi.ac.uk/ena/data/view/AP001880
EMBL	AP003420	http://www.ebi.ac.uk/ena/data/view/AP003420
EMBL	AY437532	http://www.ebi.ac.uk/ena/data/view/AY437532
EMBL	BC101316	http://www.ebi.ac.uk/ena/data/view/BC101316
Ensembl	ENST00000306494	http://www.ensembl.org/id/ENST00000306494
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005452	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005452
GO_function	GO:0015347	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015347
GO_process	GO:0043252	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043252
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC22A25	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC22A25
GeneID	387601	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=387601
GeneTree	ENSGT00760000118852	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118852
H-InvDB	HIX0017940	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0017940
HGNC	HGNC:32935	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:32935
HOGENOM	HOG000234569	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234569&db=HOGENOM6
HOVERGEN	HBG108433	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108433&db=HOVERGEN
HPA	HPA039390	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA039390
InParanoid	Q6T423	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6T423
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	387601	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=387601
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:387601	http://www.genome.jp/dbget-bin/www_bget?hsa:387601
KEGG_Orthology	KO:K08206	http://www.genome.jp/dbget-bin/www_bget?KO:K08206
MIM	610792	http://www.ncbi.nlm.nih.gov/omim/610792
OMA	APWALNH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=APWALNH
OrthoDB	EOG091G04GS	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G04GS
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:S22AP_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S22AP_HUMAN
PSORT-B	swissprot:S22AP_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S22AP_HUMAN
PSORT2	swissprot:S22AP_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S22AP_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA162403567	http://www.pharmgkb.org/do/serve?objId=PA162403567&objCls=Gene
Phobius	swissprot:S22AP_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S22AP_HUMAN
PhylomeDB	Q6T423	http://phylomedb.org/?seqid=Q6T423
ProteinModelPortal	Q6T423	http://www.proteinmodelportal.org/query/uniprot/Q6T423
PubMed	15054140	http://www.ncbi.nlm.nih.gov/pubmed/15054140
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
RefSeq	NP_955384	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_955384
RefSeq	XP_016873176	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016873176
STRING	9606.ENSP00000307443	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000307443&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.19.33	http://www.tcdb.org/search/result.php?tc=2.A.1.19.33
UCSC	uc001nwr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001nwr&org=rat
UniGene	Hs.332119	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.332119
UniProtKB	S22AP_HUMAN	http://www.uniprot.org/uniprot/S22AP_HUMAN
UniProtKB-AC	Q6T423	http://www.uniprot.org/uniprot/Q6T423
charge	swissprot:S22AP_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S22AP_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG0255	http://eggnogapi.embl.de/nog_data/html/tree/KOG0255
epestfind	swissprot:S22AP_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S22AP_HUMAN
garnier	swissprot:S22AP_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S22AP_HUMAN
helixturnhelix	swissprot:S22AP_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S22AP_HUMAN
hmoment	swissprot:S22AP_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S22AP_HUMAN
iep	swissprot:S22AP_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S22AP_HUMAN
inforesidue	swissprot:S22AP_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S22AP_HUMAN
neXtProt	NX_Q6T423	http://www.nextprot.org/db/entry/NX_Q6T423
octanol	swissprot:S22AP_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S22AP_HUMAN
pepcoil	swissprot:S22AP_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S22AP_HUMAN
pepdigest	swissprot:S22AP_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S22AP_HUMAN
pepinfo	swissprot:S22AP_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S22AP_HUMAN
pepnet	swissprot:S22AP_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S22AP_HUMAN
pepstats	swissprot:S22AP_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S22AP_HUMAN
pepwheel	swissprot:S22AP_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S22AP_HUMAN
pepwindow	swissprot:S22AP_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S22AP_HUMAN
sigcleave	swissprot:S22AP_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S22AP_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S35B2_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8TB61-1; Sequence=Displayed; Name=2; IsoId=Q8TB61-2; Sequence=VSP_014084; Name=3; IsoId=Q8TB61-3; Sequence=VSP_026949; Note=No experimental confirmation available.; Name=4; IsoId=Q8TB61-4; Sequence=VSP_054696, VSP_054697; Note=No experimental confirmation available.; Name=5; IsoId=Q8TB61-5; Sequence=VSP_057436; Note=No experimental confirmation available.; 
# AltName	S35B2_HUMAN	PAPS transporter 1
# AltName	S35B2_HUMAN	Putative MAPK-activating protein PM15
# AltName	S35B2_HUMAN	Putative NF-kappa-B-activating protein 48
# AltName	S35B2_HUMAN	Solute carrier family 35 member B2
# BIOPHYSICOCHEMICAL PROPERTIES	Kinetic parameters: KM=0.8 uM for PAPS {ECO	0000269|PubMed:12716889}; 
# BioGrid	131484	26
# CCDS	CCDS34462	-. [Q8TB61-1]
# CCDS	CCDS69127	-. [Q8TB61-4]
# CCDS	CCDS75462	-. [Q8TB61-5]
# CCDS	CCDS75463	-. [Q8TB61-3]
# ChiTaRS	SLC35B2	human
# Ensembl	ENST00000393812	ENSP00000377401; ENSG00000157593. [Q8TB61-1]
# Ensembl	ENST00000537814	ENSP00000440340; ENSG00000157593. [Q8TB61-5]
# Ensembl	ENST00000538577	ENSP00000443845; ENSG00000157593. [Q8TB61-4]
# Ensembl	ENST00000615337	ENSP00000480681; ENSG00000157593. [Q8TB61-3]
# Ensembl	ENST00000619636	ENSP00000483181; ENSG00000157593. [Q8TB61-3]
# ExpressionAtlas	Q8TB61	baseline and differential
# FUNCTION	S35B2_HUMAN	Mediates the transport of adenosine 3'-phospho 5'- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. May indirectly participate in activation of the NF- kappa-B and MAPK pathways. {ECO 0000269|PubMed 12716889}. 
# GO_component	GO:0000139	Golgi membrane; TAS:Reactome.
# GO_component	GO:0005794	Golgi apparatus; IDA:UniProtKB.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0030173	integral component of Golgi membrane; IBA:GO_Central.
# GO_component	GO:0030176	integral component of endoplasmic reticulum membrane; IBA:GO_Central.
# GO_function	GO:0004871	signal transducer activity; IMP:UniProtKB.
# GO_function	GO:0046964	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity; IDA:UniProtKB.
# GO_process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB.
# GO_process	GO:0046963	3'-phosphoadenosine 5'-phosphosulfate transport; IDA:UniProtKB.
# GO_process	GO:0050428	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006790	sulfur compound metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# Genevisible	Q8TB61	HS
# HGNC	HGNC:16872	SLC35B2
# IntAct	Q8TB61	7
# InterPro	IPR013657	UAA
# KEGG_Brite	ko02001	Solute carrier family
# MIM	610788	gene
# Organism	S35B2_HUMAN	Homo sapiens (Human)
# Pfam	PF08449	UAA
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-174362	Transport and synthesis of PAPS
# Reactome	R-HSA-727802	Transport of nucleotide sugars
# RecName	S35B2_HUMAN	Adenosine 3'-phospho 5'-phosphosulfate transporter 1
# RefSeq	NP_001273438	NM_001286509.1
# RefSeq	NP_001273439	NM_001286510.1
# RefSeq	NP_001273440	NM_001286511.1. [Q8TB61-3]
# RefSeq	NP_001273441	NM_001286512.1. [Q8TB61-3]
# RefSeq	NP_001273442	NM_001286513.1. [Q8TB61-4]
# RefSeq	NP_001273446	NM_001286517.1
# RefSeq	NP_001273448	NM_001286519.1. [Q8TB61-5]
# RefSeq	NP_001273449	NM_001286520.1. [Q8TB61-5]
# RefSeq	NP_835361	NM_178148.3. [Q8TB61-1]
# SEQUENCE CAUTION	Sequence=CAI20100.2; Type=Erroneous gene model prediction; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the nucleotide-sugar transporter family. SLC35B subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S35B2_HUMAN	Golgi apparatus membrane {ECO 0000269|PubMed 12716889}; Multi-pass membrane protein {ECO 0000269|PubMed 12716889}. 
# TCDB	2.A.7.11	the drug/metabolite transporter (dmt) superfamily
# TISSUE SPECIFICITY	Highly expressed in the placenta, pancreas, mammary gland and skeletal muscle. Weakly or not expressed in colon, heart and prostate. {ECO:0000269|PubMed	12716889}. 
# UCSC	uc003oxd	human. [Q8TB61-1]
# UCSC	uc011dvu	human
# eggNOG	COG0697	LUCA
# eggNOG	KOG1581	Eukaryota
BLAST	swissprot:S35B2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S35B2_HUMAN
BioCyc	ZFISH:ENSG00000157593-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000157593-MONOMER
COXPRESdb	347734	http://coxpresdb.jp/data/gene/347734.shtml
CleanEx	HS_SLC35B2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC35B2
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.onc.1206406	http://dx.doi.org/10.1038/sj.onc.1206406
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/jbc.M302439200	http://dx.doi.org/10.1074/jbc.M302439200
DOI	10.1093/dnares/12.2.117	http://dx.doi.org/10.1093/dnares/12.2.117
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AB097021	http://www.ebi.ac.uk/ena/data/view/AB097021
EMBL	AB097039	http://www.ebi.ac.uk/ena/data/view/AB097039
EMBL	AB106538	http://www.ebi.ac.uk/ena/data/view/AB106538
EMBL	AK075456	http://www.ebi.ac.uk/ena/data/view/AK075456
EMBL	AK223028	http://www.ebi.ac.uk/ena/data/view/AK223028
EMBL	AK293251	http://www.ebi.ac.uk/ena/data/view/AK293251
EMBL	AK293344	http://www.ebi.ac.uk/ena/data/view/AK293344
EMBL	AL139392	http://www.ebi.ac.uk/ena/data/view/AL139392
EMBL	AL139392	http://www.ebi.ac.uk/ena/data/view/AL139392
EMBL	AY491520	http://www.ebi.ac.uk/ena/data/view/AY491520
EMBL	BC016839	http://www.ebi.ac.uk/ena/data/view/BC016839
EMBL	BC024288	http://www.ebi.ac.uk/ena/data/view/BC024288
Ensembl	ENST00000393812	http://www.ensembl.org/id/ENST00000393812
Ensembl	ENST00000537814	http://www.ensembl.org/id/ENST00000537814
Ensembl	ENST00000538577	http://www.ensembl.org/id/ENST00000538577
Ensembl	ENST00000615337	http://www.ensembl.org/id/ENST00000615337
Ensembl	ENST00000619636	http://www.ensembl.org/id/ENST00000619636
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030173	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030173
GO_component	GO:0030176	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030176
GO_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GO_function	GO:0046964	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046964
GO_process	GO:0043123	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043123
GO_process	GO:0046963	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046963
GO_process	GO:0050428	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050428
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GeneCards	SLC35B2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC35B2
GeneID	347734	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=347734
GeneTree	ENSGT00530000063090	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063090
HGNC	HGNC:16872	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16872
HOVERGEN	HBG062347	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG062347&db=HOVERGEN
HPA	HPA029638	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA029638
IntAct	Q8TB61	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8TB61*
InterPro	IPR013657	http://www.ebi.ac.uk/interpro/entry/IPR013657
Jabion	347734	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=347734
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:347734	http://www.genome.jp/dbget-bin/www_bget?hsa:347734
KEGG_Orthology	KO:K15276	http://www.genome.jp/dbget-bin/www_bget?KO:K15276
MIM	610788	http://www.ncbi.nlm.nih.gov/omim/610788
OMA	YEYYEYV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YEYYEYV
OrthoDB	EOG091G07O2	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07O2
PSORT	swissprot:S35B2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S35B2_HUMAN
PSORT-B	swissprot:S35B2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S35B2_HUMAN
PSORT2	swissprot:S35B2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S35B2_HUMAN
Pfam	PF08449	http://pfam.xfam.org/family/PF08449
PharmGKB	PA134927864	http://www.pharmgkb.org/do/serve?objId=PA134927864&objCls=Gene
Phobius	swissprot:S35B2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S35B2_HUMAN
PhylomeDB	Q8TB61	http://phylomedb.org/?seqid=Q8TB61
ProteinModelPortal	Q8TB61	http://www.proteinmodelportal.org/query/uniprot/Q8TB61
PubMed	12716889	http://www.ncbi.nlm.nih.gov/pubmed/12716889
PubMed	12761501	http://www.ncbi.nlm.nih.gov/pubmed/12761501
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16303743	http://www.ncbi.nlm.nih.gov/pubmed/16303743
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-174362	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-174362
Reactome	R-HSA-727802	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-727802
RefSeq	NP_001273438	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273438
RefSeq	NP_001273439	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273439
RefSeq	NP_001273440	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273440
RefSeq	NP_001273441	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273441
RefSeq	NP_001273442	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273442
RefSeq	NP_001273446	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273446
RefSeq	NP_001273448	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273448
RefSeq	NP_001273449	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273449
RefSeq	NP_835361	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_835361
STRING	9606.ENSP00000377401	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000377401&targetmode=cogs
TCDB	2.A.7.11	http://www.tcdb.org/search/result.php?tc=2.A.7.11
UCSC	uc003oxd	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003oxd&org=rat
UCSC	uc011dvu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc011dvu&org=rat
UniGene	Hs.182885	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.182885
UniProtKB	S35B2_HUMAN	http://www.uniprot.org/uniprot/S35B2_HUMAN
UniProtKB-AC	Q8TB61	http://www.uniprot.org/uniprot/Q8TB61
charge	swissprot:S35B2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S35B2_HUMAN
eggNOG	COG0697	http://eggnogapi.embl.de/nog_data/html/tree/COG0697
eggNOG	KOG1581	http://eggnogapi.embl.de/nog_data/html/tree/KOG1581
epestfind	swissprot:S35B2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S35B2_HUMAN
garnier	swissprot:S35B2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S35B2_HUMAN
helixturnhelix	swissprot:S35B2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S35B2_HUMAN
hmoment	swissprot:S35B2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S35B2_HUMAN
iep	swissprot:S35B2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S35B2_HUMAN
inforesidue	swissprot:S35B2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S35B2_HUMAN
neXtProt	NX_Q8TB61	http://www.nextprot.org/db/entry/NX_Q8TB61
octanol	swissprot:S35B2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S35B2_HUMAN
pepcoil	swissprot:S35B2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S35B2_HUMAN
pepdigest	swissprot:S35B2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S35B2_HUMAN
pepinfo	swissprot:S35B2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S35B2_HUMAN
pepnet	swissprot:S35B2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S35B2_HUMAN
pepstats	swissprot:S35B2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S35B2_HUMAN
pepwheel	swissprot:S35B2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S35B2_HUMAN
pepwindow	swissprot:S35B2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S35B2_HUMAN
sigcleave	swissprot:S35B2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S35B2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GTR5_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P22732-1; Sequence=Displayed; Name=2; IsoId=P22732-2; Sequence=VSP_042031; 
# AltName	GTR5_HUMAN	Fructose transporter
# AltName	GTR5_HUMAN	Glucose transporter type 5, small intestine
# BioGrid	112409	11
# CCDS	CCDS44054	-. [P22732-2]
# CCDS	CCDS99	-. [P22732-1]
# CDD	cd06174	MFS
# ChiTaRS	SLC2A5	human
# ENZYME REGULATION	The uptake of 2-deoxyglucose is inhibited by cytochalasin B. {ECO:0000269|PubMed	1695905}. 
# Ensembl	ENST00000377414	ENSP00000366631; ENSG00000142583. [P22732-2]
# Ensembl	ENST00000377424	ENSP00000366641; ENSG00000142583. [P22732-1]
# ExpressionAtlas	P22732	baseline and differential
# FUNCTION	GTR5_HUMAN	Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed 8333543). Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed 1695905). Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake (By similarity). {ECO 0000250|UniProtKB Q9WV38, ECO 0000269|PubMed 1695905, ECO 0000269|PubMed 8333543}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; ISS:UniProtKB.
# GO_component	GO:0042383	sarcolemma; ISS:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005353	fructose transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0005355	glucose transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0070061	fructose binding; ISS:UniProtKB.
# GO_process	GO:0003044	regulation of systemic arterial blood pressure mediated by a chemical signal; ISS:UniProtKB.
# GO_process	GO:0005975	carbohydrate metabolic process; TAS:ProtInc.
# GO_process	GO:0008645	hexose transport; TAS:Reactome.
# GO_process	GO:0009750	response to fructose; ISS:UniProtKB.
# GO_process	GO:0015755	fructose transport; TAS:ProtInc.
# GO_process	GO:0015758	glucose transport; TAS:ProtInc.
# GO_process	GO:0071332	cellular response to fructose stimulus; ISS:UniProtKB.
# GO_process	GO:1990539	fructose import across plasma membrane; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0005975	carbohydrate metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P22732	HS
# HGNC	HGNC:11010	SLC2A5
# INDUCTION	By forskolin in Caco-2 cells. {ECO:0000269|PubMed	8037665}. 
# IntAct	P22732	3
# InterPro	IPR002442	Fru_transpt_5
# InterPro	IPR003663	Sugar/inositol_transpt
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR005829	Sugar_transporter_CS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04973	Carbohydrate digestion and absorption
# MASS SPECTROMETRY	Mass=54973.98; Method=MALDI; Range=1-501; Evidence={ECO:0000269|PubMed	11840567}; 
# MIM	138230	gene
# Organism	GTR5_HUMAN	Homo sapiens (Human)
# PDB	1YG1	Model; -; A=1-501
# PIR	A36629	A36629
# PIR	G02864	G02864
# PRINTS	PR00171	SUGRTRNSPORT
# PRINTS	PR01194	GLUCTRSPORT5
# PROSITE	PS00216	SUGAR_TRANSPORT_1
# PROSITE	PS00217	SUGAR_TRANSPORT_2
# PROSITE	PS50850	MFS
# Pfam	PF00083	Sugar_tr
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-189200	Hexose transport
# Reactome	R-HSA-428776	Class II GLUTs
# Reactome	R-HSA-6798695	Neutrophil degranulation
# RecName	GTR5_HUMAN	Solute carrier family 2, facilitated glucose transporter member 5
# RefSeq	NP_001129057	NM_001135585.1. [P22732-2]
# RefSeq	NP_001315548	NM_001328619.1. [P22732-1]
# RefSeq	NP_003030	NM_003039.2. [P22732-1]
# RefSeq	XP_005263548	XM_005263491.3. [P22732-1]
# RefSeq	XP_016857622	XM_017002133.1. [P22732-1]
# RefSeq	XP_016857623	XM_017002134.1. [P22732-1]
# RefSeq	XP_016857624	XM_017002135.1. [P22732-1]
# RefSeq	XP_016857625	XM_017002136.1. [P22732-1]
# RefSeq	XP_016857626	XM_017002137.1. [P22732-1]
# RefSeq	XP_016857627	XM_017002138.1. [P22732-1]
# RefSeq	XP_016857629	XM_017002140.1. [P22732-1]
# RefSeq	XP_016857630	XM_017002141.1. [P22732-1]
# SEQUENCE CAUTION	Sequence=AAB60641.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	GTR5_HUMAN	Apical cell membrane {ECO 0000250|UniProtKB Q9WV38}; Multi-pass membrane protein {ECO 0000250|UniProtKB Q9WV38}. Cell membrane {ECO 0000269|PubMed 1695905, ECO 0000269|PubMed 7619085, ECO 0000269|PubMed 8333543}; Multi-pass membrane protein {ECO 0000250|UniProtKB Q9WV38}. Cell membrane, sarcolemma {ECO 0000250|UniProtKB P43427}. Note=Localized on the apical membrane of jejunum villi, but also on lateral plasma membranes of the villi. Transport to the cell membrane is dependent on RAB11A. {ECO 0000250|UniProtKB Q9WV38}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.1.13	the major facilitator superfamily (mfs)
# TIGRFAMs	TIGR00879	SP
# TISSUE SPECIFICITY	GTR5_HUMAN	Detected in skeletal muscle, and in jejunum brush border membrane and basolateral membrane (at protein level) (PubMed 7619085). Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose tissue. {ECO 0000269|PubMed 1695905, ECO 0000269|PubMed 7619085}. 
# UCSC	uc001apo	human. [P22732-1]
# eggNOG	COG0477	LUCA
# eggNOG	KOG0569	Eukaryota
BLAST	swissprot:GTR5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GTR5_HUMAN
BioCyc	ZFISH:ENSG00000142583-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000142583-MONOMER
COXPRESdb	6518	http://coxpresdb.jp/data/gene/6518.shtml
CleanEx	HS_SLC2A5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC2A5
DOI	10.1002/1615-9861(200202)2:2<212::AID-PROT212>3.0.CO	http://dx.doi.org/10.1002/1615-9861(200202)2:2<212::AID-PROT212>3.0.CO
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/bj3010169	http://dx.doi.org/10.1042/bj3010169
DOI	10.1042/bj3090007	http://dx.doi.org/10.1042/bj3090007
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AK289849	http://www.ebi.ac.uk/ena/data/view/AK289849
EMBL	AK290398	http://www.ebi.ac.uk/ena/data/view/AK290398
EMBL	AL158048	http://www.ebi.ac.uk/ena/data/view/AL158048
EMBL	AL158048	http://www.ebi.ac.uk/ena/data/view/AL158048
EMBL	BC001692	http://www.ebi.ac.uk/ena/data/view/BC001692
EMBL	BC001820	http://www.ebi.ac.uk/ena/data/view/BC001820
EMBL	BC035878	http://www.ebi.ac.uk/ena/data/view/BC035878
EMBL	CH471130	http://www.ebi.ac.uk/ena/data/view/CH471130
EMBL	M55531	http://www.ebi.ac.uk/ena/data/view/M55531
EMBL	U05344	http://www.ebi.ac.uk/ena/data/view/U05344
EMBL	U11839	http://www.ebi.ac.uk/ena/data/view/U11839
EMBL	U11840	http://www.ebi.ac.uk/ena/data/view/U11840
EMBL	U11841	http://www.ebi.ac.uk/ena/data/view/U11841
EMBL	U11842	http://www.ebi.ac.uk/ena/data/view/U11842
EMBL	U11843	http://www.ebi.ac.uk/ena/data/view/U11843
Ensembl	ENST00000377414	http://www.ensembl.org/id/ENST00000377414
Ensembl	ENST00000377424	http://www.ensembl.org/id/ENST00000377424
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0042383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042383
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005353	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005353
GO_function	GO:0005355	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005355
GO_function	GO:0070061	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070061
GO_process	GO:0003044	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003044
GO_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GO_process	GO:0008645	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008645
GO_process	GO:0009750	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009750
GO_process	GO:0015755	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015755
GO_process	GO:0015758	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015758
GO_process	GO:0071332	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071332
GO_process	GO:1990539	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990539
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC2A5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC2A5
GeneID	6518	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6518
GeneTree	ENSGT00760000119022	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119022
HGNC	HGNC:11010	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11010
HOGENOM	HOG000202871	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202871&db=HOGENOM6
HOVERGEN	HBG014816	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG014816&db=HOVERGEN
HPA	CAB026176	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB026176
HPA	HPA005449	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA005449
InParanoid	P22732	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P22732
IntAct	P22732	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P22732*
InterPro	IPR002442	http://www.ebi.ac.uk/interpro/entry/IPR002442
InterPro	IPR003663	http://www.ebi.ac.uk/interpro/entry/IPR003663
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR005829	http://www.ebi.ac.uk/interpro/entry/IPR005829
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	6518	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6518
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6518	http://www.genome.jp/dbget-bin/www_bget?hsa:6518
KEGG_Orthology	KO:K08143	http://www.genome.jp/dbget-bin/www_bget?KO:K08143
KEGG_Pathway	ko04973	http://www.genome.jp/kegg-bin/show_pathway?ko04973
MIM	138230	http://www.ncbi.nlm.nih.gov/omim/138230
OMA	WDSVDRE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WDSVDRE
OrthoDB	EOG091G0A9K	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0A9K
PDB	1YG1	http://www.ebi.ac.uk/pdbe-srv/view/entry/1YG1
PDBsum	1YG1	http://www.ebi.ac.uk/pdbsum/1YG1
PRINTS	PR00171	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00171
PRINTS	PR01194	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01194
PROSITE	PS00216	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00216
PROSITE	PS00217	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00217
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:GTR5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GTR5_HUMAN
PSORT-B	swissprot:GTR5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GTR5_HUMAN
PSORT2	swissprot:GTR5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GTR5_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
PharmGKB	PA35880	http://www.pharmgkb.org/do/serve?objId=PA35880&objCls=Gene
Phobius	swissprot:GTR5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GTR5_HUMAN
PhylomeDB	P22732	http://phylomedb.org/?seqid=P22732
ProteinModelPortal	P22732	http://www.proteinmodelportal.org/query/uniprot/P22732
PubMed	11840567	http://www.ncbi.nlm.nih.gov/pubmed/11840567
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	1695905	http://www.ncbi.nlm.nih.gov/pubmed/1695905
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	7619085	http://www.ncbi.nlm.nih.gov/pubmed/7619085
PubMed	8037665	http://www.ncbi.nlm.nih.gov/pubmed/8037665
PubMed	8333543	http://www.ncbi.nlm.nih.gov/pubmed/8333543
Reactome	R-HSA-189200	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-189200
Reactome	R-HSA-428776	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428776
Reactome	R-HSA-6798695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6798695
RefSeq	NP_001129057	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001129057
RefSeq	NP_001315548	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001315548
RefSeq	NP_003030	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003030
RefSeq	XP_005263548	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005263548
RefSeq	XP_016857622	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016857622
RefSeq	XP_016857623	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016857623
RefSeq	XP_016857624	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016857624
RefSeq	XP_016857625	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016857625
RefSeq	XP_016857626	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016857626
RefSeq	XP_016857627	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016857627
RefSeq	XP_016857629	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016857629
RefSeq	XP_016857630	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016857630
SMR	P22732	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P22732
STRING	9606.ENSP00000366641	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000366641&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.1.13	http://www.tcdb.org/search/result.php?tc=2.A.1.1.13
TIGRFAMs	TIGR00879	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00879
UCSC	uc001apo	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001apo&org=rat
UniGene	Hs.530003	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.530003
UniProtKB	GTR5_HUMAN	http://www.uniprot.org/uniprot/GTR5_HUMAN
UniProtKB-AC	P22732	http://www.uniprot.org/uniprot/P22732
charge	swissprot:GTR5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GTR5_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG0569	http://eggnogapi.embl.de/nog_data/html/tree/KOG0569
epestfind	swissprot:GTR5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GTR5_HUMAN
garnier	swissprot:GTR5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GTR5_HUMAN
helixturnhelix	swissprot:GTR5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GTR5_HUMAN
hmoment	swissprot:GTR5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GTR5_HUMAN
iep	swissprot:GTR5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GTR5_HUMAN
inforesidue	swissprot:GTR5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GTR5_HUMAN
neXtProt	NX_P22732	http://www.nextprot.org/db/entry/NX_P22732
octanol	swissprot:GTR5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GTR5_HUMAN
pepcoil	swissprot:GTR5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GTR5_HUMAN
pepdigest	swissprot:GTR5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GTR5_HUMAN
pepinfo	swissprot:GTR5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GTR5_HUMAN
pepnet	swissprot:GTR5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GTR5_HUMAN
pepstats	swissprot:GTR5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GTR5_HUMAN
pepwheel	swissprot:GTR5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GTR5_HUMAN
pepwindow	swissprot:GTR5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GTR5_HUMAN
sigcleave	swissprot:GTR5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GTR5_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	LAT1L_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9GIP4-3; Sequence=Displayed; Name=2; IsoId=Q9GIP4-1; Sequence=VSP_040419; 
# AltName	LAT1L_HUMAN	hLAT1 3-transmembrane protein IMAA
# AltName	LAT1L_HUMAN	hLAT1 3-transmembrane protein MMAA
# CAUTION	Could be the product of a pseudogene. {ECO	0000305}.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; IEA:InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# HGNC	HGNC:24951	SLC7A5P2
# INDUCTION	Up-regulated by concanavalin-A stimulation. {ECO:0000269|PubMed	12009310}. 
# InterPro	IPR002293	AA/rel_permease1
# Organism	LAT1L_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11785	PTHR11785
# Pfam	PF13520	AA_permease_2
# Proteomes	UP000005640	Unplaced
# RecName	LAT1L_HUMAN	Putative L-type amino acid transporter 1-like protein IMAA
# SIMILARITY	Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	LAT1L_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TISSUE SPECIFICITY	Expressed in peripheral blood mononuclear cells and lymphoid and myeloid cell lines. {ECO:0000269|PubMed	12009310}. 
# TopDownProteomics	Q9GIP4-3	-. [Q9GIP4-3]
BLAST	swissprot:LAT1L_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:LAT1L_HUMAN
BioCyc	ZFISH:G66-30916-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-30916-MONOMER
DOI	10.1016/S1357-2725(02)00036-5	http://dx.doi.org/10.1016/S1357-2725(02)00036-5
DOI	10.1038/nature03187	http://dx.doi.org/10.1038/nature03187
EMBL	AB040413	http://www.ebi.ac.uk/ena/data/view/AB040413
EMBL	AB055225	http://www.ebi.ac.uk/ena/data/view/AB055225
EMBL	AB055227	http://www.ebi.ac.uk/ena/data/view/AB055227
EMBL	AC005632	http://www.ebi.ac.uk/ena/data/view/AC005632
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GeneCards	SLC7A5P2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC7A5P2
HGNC	HGNC:24951	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:24951
HOGENOM	HOG000124567	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124567&db=HOGENOM6
HOVERGEN	HBG061804	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG061804&db=HOVERGEN
HPA	HPA052673	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA052673
InParanoid	Q9GIP4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9GIP4
InterPro	IPR002293	http://www.ebi.ac.uk/interpro/entry/IPR002293
PANTHER	PTHR11785	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785
PSORT	swissprot:LAT1L_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:LAT1L_HUMAN
PSORT-B	swissprot:LAT1L_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:LAT1L_HUMAN
PSORT2	swissprot:LAT1L_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:LAT1L_HUMAN
Pfam	PF13520	http://pfam.xfam.org/family/PF13520
Phobius	swissprot:LAT1L_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:LAT1L_HUMAN
PhylomeDB	Q9GIP4	http://phylomedb.org/?seqid=Q9GIP4
ProteinModelPortal	Q9GIP4	http://www.proteinmodelportal.org/query/uniprot/Q9GIP4
PubMed	12009310	http://www.ncbi.nlm.nih.gov/pubmed/12009310
PubMed	15616553	http://www.ncbi.nlm.nih.gov/pubmed/15616553
SMR	Q9GIP4	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9GIP4
UniGene	Hs.448808	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.448808
UniGene	Hs.664952	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.664952
UniProtKB	LAT1L_HUMAN	http://www.uniprot.org/uniprot/LAT1L_HUMAN
UniProtKB-AC	Q9GIP4	http://www.uniprot.org/uniprot/Q9GIP4
charge	swissprot:LAT1L_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:LAT1L_HUMAN
epestfind	swissprot:LAT1L_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:LAT1L_HUMAN
garnier	swissprot:LAT1L_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:LAT1L_HUMAN
helixturnhelix	swissprot:LAT1L_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:LAT1L_HUMAN
hmoment	swissprot:LAT1L_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:LAT1L_HUMAN
iep	swissprot:LAT1L_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:LAT1L_HUMAN
inforesidue	swissprot:LAT1L_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:LAT1L_HUMAN
neXtProt	NX_Q9GIP4	http://www.nextprot.org/db/entry/NX_Q9GIP4
octanol	swissprot:LAT1L_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:LAT1L_HUMAN
pepcoil	swissprot:LAT1L_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:LAT1L_HUMAN
pepdigest	swissprot:LAT1L_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:LAT1L_HUMAN
pepinfo	swissprot:LAT1L_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:LAT1L_HUMAN
pepnet	swissprot:LAT1L_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:LAT1L_HUMAN
pepstats	swissprot:LAT1L_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:LAT1L_HUMAN
pepwheel	swissprot:LAT1L_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:LAT1L_HUMAN
pepwindow	swissprot:LAT1L_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:LAT1L_HUMAN
sigcleave	swissprot:LAT1L_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:LAT1L_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	MRP5_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=O15440-1; Sequence=Displayed; Name=2; Synonyms=SV1; IsoId=O15440-2; Sequence=VSP_043397, VSP_043402; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; Synonyms=SV2; IsoId=O15440-3; Sequence=VSP_043398, VSP_043401, VSP_043402; Note=Predominant isoform in retinal pigment epithelium, bladder, and stomach.; Name=4; Synonyms=SV3; IsoId=O15440-4; Sequence=VSP_043399, VSP_043400, VSP_043402; Name=5; IsoId=O15440-5; Sequence=VSP_055354; 
# AltName	MRP5_HUMAN	ATP-binding cassette sub-family C member 5
# AltName	MRP5_HUMAN	Multi-specific organic anion transporter C
# AltName	MRP5_HUMAN	SMRP
# AltName	MRP5_HUMAN	pABC11
# BioGrid	115368	12
# CCDS	CCDS33898	-. [O15440-4]
# CCDS	CCDS43176	-. [O15440-1]
# ChiTaRS	ABCC5	human
# DrugBank	DB00143	Glutathione
# DrugBank	DB00203	Sildenafil
# DrugBank	DB00495	Zidovudine
# DrugBank	DB00515	Cisplatin
# DrugBank	DB00544	Fluorouracil
# DrugBank	DB00718	Adefovir Dipivoxil
# DrugBank	DB00770	Alprostadil
# DrugBank	DB00917	Dinoprostone
# DrugBank	DB00975	Dipyridamole
# DrugBank	DB01032	Probenecid
# DrugBank	DB01033	Mercaptopurine
# DrugBank	DB01045	Rifampicin
# DrugBank	DB01076	Atorvastatin
# DrugBank	DB01138	Sulfinpyrazone
# Ensembl	ENST00000265586	ENSP00000265586; ENSG00000114770. [O15440-5]
# Ensembl	ENST00000334444	ENSP00000333926; ENSG00000114770. [O15440-1]
# Ensembl	ENST00000382494	ENSP00000371934; ENSG00000114770. [O15440-4]
# Ensembl	ENST00000392579	ENSP00000376358; ENSG00000114770. [O15440-2]
# Ensembl	ENST00000443376	ENSP00000416840; ENSG00000114770. [O15440-3]
# ExpressionAtlas	O15440	baseline and differential
# FUNCTION	MRP5_HUMAN	Acts as a multispecific organic anion pump which can transport nucleotide analogs. {ECO 0000269|PubMed 10840050}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; IDA:MGI.
# GO_function	GO:0005524	ATP binding; TAS:ProtInc.
# GO_function	GO:0008514	organic anion transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0043225	ATPase-coupled anion transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0030213	hyaluronan biosynthetic process; TAS:Reactome.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 2.
# Genevisible	O15440	HS
# HGNC	HGNC:56	ABCC5
# IntAct	O15440	8
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR011527	ABC1_TM_dom
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR027417	P-loop_NTPase
# InterPro	IPR030238	ABCC5
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko02010	ABC transporters
# MIM	605251	gene
# Organism	MRP5_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR24223:SF196	PTHR24223:SF196; 2
# PIR	JC5667	JC5667
# PROSITE	PS00211	ABC_TRANSPORTER_1; 2
# PROSITE	PS50893	ABC_TRANSPORTER_2; 2
# PROSITE	PS50929	ABC_TM1F; 2
# Pfam	PF00005	ABC_tran; 2
# Pfam	PF00664	ABC_membrane; 2
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-2142850	Hyaluronan biosynthesis and export
# Reactome	R-HSA-382556	ABC-family proteins mediated transport
# RecName	MRP5_HUMAN	Multidrug resistance-associated protein 5
# RefSeq	NP_001018881	NM_001023587.2. [O15440-4]
# RefSeq	NP_001306961	NM_001320032.1
# RefSeq	NP_005679	NM_005688.3. [O15440-1]
# RefSeq	XP_005247115	XM_005247058.4. [O15440-1]
# RefSeq	XP_005247116	XM_005247059.4. [O15440-1]
# RefSeq	XP_011510616	XM_011512314.1. [O15440-1]
# RefSeq	XP_016860982	XM_017005493.1. [O15440-4]
# RefSeq	XP_016860983	XM_017005494.1. [O15440-4]
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 2 ABC transmembrane type-1 domains. {ECO:0000255|PROSITE-ProRule	PRU00441}. 
# SIMILARITY	Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA; 2
# SUBCELLULAR LOCATION	MRP5_HUMAN	Membrane; Multi-pass membrane protein. 
# SUPFAM	SSF52540	SSF52540; 2
# SUPFAM	SSF90123	SSF90123; 2
# TCDB	3.A.1.208.15	the atp-binding cassette (abc) superfamily
# TISSUE SPECIFICITY	All isoforms are equally expressed in retina. {ECO:0000269|PubMed	17521428}. 
# UCSC	uc003fmg	human. [O15440-1]
# WEB RESOURCE	MRP5_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=O15440";
# eggNOG	COG1132	LUCA
# eggNOG	KOG0054	Eukaryota
BLAST	swissprot:MRP5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MRP5_HUMAN
BioCyc	ZFISH:ENSG00000114770-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000114770-MONOMER
COXPRESdb	10057	http://coxpresdb.jp/data/gene/10057.shtml
CleanEx	HS_ABCC5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCC5
DOI	10.1006/bbrc.1997.7346	http://dx.doi.org/10.1006/bbrc.1997.7346
DOI	10.1016/S0378-1119(99)00529-6	http://dx.doi.org/10.1016/S0378-1119(99)00529-6
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.120159197	http://dx.doi.org/10.1073/pnas.120159197
DOI	10.1074/jbc.274.33.23541	http://dx.doi.org/10.1074/jbc.274.33.23541
DOI	10.1093/jnci/90.22.1735	http://dx.doi.org/10.1093/jnci/90.22.1735
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1186/1471-2199-8-42	http://dx.doi.org/10.1186/1471-2199-8-42
DrugBank	DB00143	http://www.drugbank.ca/drugs/DB00143
DrugBank	DB00203	http://www.drugbank.ca/drugs/DB00203
DrugBank	DB00495	http://www.drugbank.ca/drugs/DB00495
DrugBank	DB00515	http://www.drugbank.ca/drugs/DB00515
DrugBank	DB00544	http://www.drugbank.ca/drugs/DB00544
DrugBank	DB00718	http://www.drugbank.ca/drugs/DB00718
DrugBank	DB00770	http://www.drugbank.ca/drugs/DB00770
DrugBank	DB00917	http://www.drugbank.ca/drugs/DB00917
DrugBank	DB00975	http://www.drugbank.ca/drugs/DB00975
DrugBank	DB01032	http://www.drugbank.ca/drugs/DB01032
DrugBank	DB01033	http://www.drugbank.ca/drugs/DB01033
DrugBank	DB01045	http://www.drugbank.ca/drugs/DB01045
DrugBank	DB01076	http://www.drugbank.ca/drugs/DB01076
DrugBank	DB01138	http://www.drugbank.ca/drugs/DB01138
EMBL	AB005659	http://www.ebi.ac.uk/ena/data/view/AB005659
EMBL	AB019002	http://www.ebi.ac.uk/ena/data/view/AB019002
EMBL	AC068644	http://www.ebi.ac.uk/ena/data/view/AC068644
EMBL	AF104942	http://www.ebi.ac.uk/ena/data/view/AF104942
EMBL	AF146074	http://www.ebi.ac.uk/ena/data/view/AF146074
EMBL	AY196484	http://www.ebi.ac.uk/ena/data/view/AY196484
EMBL	AY754874	http://www.ebi.ac.uk/ena/data/view/AY754874
EMBL	AY754875	http://www.ebi.ac.uk/ena/data/view/AY754875
EMBL	AY754876	http://www.ebi.ac.uk/ena/data/view/AY754876
EMBL	BC050744	http://www.ebi.ac.uk/ena/data/view/BC050744
EMBL	BC140771	http://www.ebi.ac.uk/ena/data/view/BC140771
EMBL	BC142719	http://www.ebi.ac.uk/ena/data/view/BC142719
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
EMBL	U83661	http://www.ebi.ac.uk/ena/data/view/U83661
Ensembl	ENST00000265586	http://www.ensembl.org/id/ENST00000265586
Ensembl	ENST00000334444	http://www.ensembl.org/id/ENST00000334444
Ensembl	ENST00000382494	http://www.ensembl.org/id/ENST00000382494
Ensembl	ENST00000392579	http://www.ensembl.org/id/ENST00000392579
Ensembl	ENST00000443376	http://www.ensembl.org/id/ENST00000443376
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0008514	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008514
GO_function	GO:0043225	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043225
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0030213	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030213
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCC5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCC5
GeneID	10057	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10057
GeneTree	ENSGT00860000133722	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00860000133722
HGNC	HGNC:56	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:56
HOGENOM	HOG000116132	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116132&db=HOGENOM6
HOVERGEN	HBG108314	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108314&db=HOVERGEN
HPA	HPA044067	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA044067
HPA	HPA052295	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA052295
InParanoid	O15440	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O15440
IntAct	O15440	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O15440*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR011527	http://www.ebi.ac.uk/interpro/entry/IPR011527
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
InterPro	IPR030238	http://www.ebi.ac.uk/interpro/entry/IPR030238
Jabion	10057	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10057
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:10057	http://www.genome.jp/dbget-bin/www_bget?hsa:10057
KEGG_Orthology	KO:K05668	http://www.genome.jp/dbget-bin/www_bget?KO:K05668
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
MIM	605251	http://www.ncbi.nlm.nih.gov/omim/605251
OMA	KHIHLGS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KHIHLGS
OrthoDB	EOG091G01TC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01TC
PANTHER	PTHR24223:SF196	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24223:SF196
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PROSITE	PS50929	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929
PSORT	swissprot:MRP5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MRP5_HUMAN
PSORT-B	swissprot:MRP5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MRP5_HUMAN
PSORT2	swissprot:MRP5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MRP5_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF00664	http://pfam.xfam.org/family/PF00664
PharmGKB	PA395	http://www.pharmgkb.org/do/serve?objId=PA395&objCls=Gene
Phobius	swissprot:MRP5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MRP5_HUMAN
PhylomeDB	O15440	http://phylomedb.org/?seqid=O15440
ProteinModelPortal	O15440	http://www.proteinmodelportal.org/query/uniprot/O15440
PubMed	10438534	http://www.ncbi.nlm.nih.gov/pubmed/10438534
PubMed	10721709	http://www.ncbi.nlm.nih.gov/pubmed/10721709
PubMed	10840050	http://www.ncbi.nlm.nih.gov/pubmed/10840050
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	17521428	http://www.ncbi.nlm.nih.gov/pubmed/17521428
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	9270026	http://www.ncbi.nlm.nih.gov/pubmed/9270026
PubMed	9325169	http://www.ncbi.nlm.nih.gov/pubmed/9325169
PubMed	9827529	http://www.ncbi.nlm.nih.gov/pubmed/9827529
Reactome	R-HSA-2142850	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2142850
Reactome	R-HSA-382556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-382556
RefSeq	NP_001018881	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001018881
RefSeq	NP_001306961	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001306961
RefSeq	NP_005679	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005679
RefSeq	XP_005247115	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005247115
RefSeq	XP_005247116	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005247116
RefSeq	XP_011510616	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011510616
RefSeq	XP_016860982	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016860982
RefSeq	XP_016860983	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016860983
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	O15440	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O15440
STRING	9606.ENSP00000333926	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000333926&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
SUPFAM	SSF90123	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123
TCDB	3.A.1.208.15	http://www.tcdb.org/search/result.php?tc=3.A.1.208.15
UCSC	uc003fmg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003fmg&org=rat
UniGene	Hs.368563	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.368563
UniGene	Hs.732645	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.732645
UniGene	Hs.743953	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.743953
UniProtKB	MRP5_HUMAN	http://www.uniprot.org/uniprot/MRP5_HUMAN
UniProtKB-AC	O15440	http://www.uniprot.org/uniprot/O15440
charge	swissprot:MRP5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MRP5_HUMAN
eggNOG	COG1132	http://eggnogapi.embl.de/nog_data/html/tree/COG1132
eggNOG	KOG0054	http://eggnogapi.embl.de/nog_data/html/tree/KOG0054
epestfind	swissprot:MRP5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MRP5_HUMAN
garnier	swissprot:MRP5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MRP5_HUMAN
helixturnhelix	swissprot:MRP5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MRP5_HUMAN
hmoment	swissprot:MRP5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MRP5_HUMAN
iep	swissprot:MRP5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MRP5_HUMAN
inforesidue	swissprot:MRP5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MRP5_HUMAN
neXtProt	NX_O15440	http://www.nextprot.org/db/entry/NX_O15440
octanol	swissprot:MRP5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MRP5_HUMAN
pepcoil	swissprot:MRP5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MRP5_HUMAN
pepdigest	swissprot:MRP5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MRP5_HUMAN
pepinfo	swissprot:MRP5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MRP5_HUMAN
pepnet	swissprot:MRP5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MRP5_HUMAN
pepstats	swissprot:MRP5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MRP5_HUMAN
pepwheel	swissprot:MRP5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MRP5_HUMAN
pepwindow	swissprot:MRP5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MRP5_HUMAN
sigcleave	swissprot:MRP5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MRP5_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S12A6_HUMAN	Event=Alternative promoter usage, Alternative splicing; Named isoforms=6; Name=1; Synonyms=KCC3a; IsoId=Q9UHW9-1; Sequence=Displayed; Name=2; Synonyms=KCC3b; IsoId=Q9UHW9-2; Sequence=VSP_006115, VSP_006116; Note=Produced by alternative promoter usage.; Name=3; Synonyms=KCC3a-X2M; IsoId=Q9UHW9-3; Sequence=VSP_041389; Note=Does not differ in the osmotic set point of swelling activation but, activation is more rapid.; Name=4; Synonyms=KCC3a-S3; IsoId=Q9UHW9-4; Sequence=VSP_041388; Name=5; Synonyms=KCC3a-S, KCC3a-S1, KCC3a-S2; IsoId=Q9UHW9-5; Sequence=VSP_041387; Note=Does not differ in the osmotic set point of swelling activation but, activation is more rapid.; Name=6; Synonyms=KCC3b-X2M; IsoId=Q9UHW9-6; Sequence=VSP_006115, VSP_006116, VSP_041389; 
# AltName	S12A6_HUMAN	Electroneutral potassium-chloride cotransporter 3
# AltName	S12A6_HUMAN	K-Cl cotransporter 3
# BIOPHYSICOCHEMICAL PROPERTIES	S12A6_HUMAN	Kinetic parameters  KM=10.7 mM for extracellular Rb(+) (isoform 1) {ECO 0000269|PubMed 16048901}; KM=7.3 mM for extracellular Cl(-) (isoform 1) {ECO 0000269|PubMed 16048901}; KM=17.2 mM for extracellular Rb(+) (isoform 2) {ECO 0000269|PubMed 16048901}; KM=8.2 mM for extracellular Cl(-) (isoform 2) {ECO 0000269|PubMed 16048901}; 
# BioGrid	115311	14
# CCDS	CCDS10036	-. [Q9UHW9-2]
# CCDS	CCDS42010	-. [Q9UHW9-3]
# CCDS	CCDS42011	-. [Q9UHW9-4]
# CCDS	CCDS42012	-. [Q9UHW9-5]
# CCDS	CCDS58352	-. [Q9UHW9-1]
# ChiTaRS	SLC12A6	human
# DISEASE	S12A6_HUMAN	Agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) [MIM 218000]  A disease that is characterized by severe progressive sensorimotor neuropathy, mental retardation, dysmorphic features and complete or partial agenesis of the corpus callosum. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00761	Potassium Chloride
# ENZYME REGULATION	Activated by N-ethylmaleimide (NEM). Inhibited by DIOA, bumetanide and furosemide. Inhibited by WNK3. {ECO:0000269|PubMed	21613606}. 
# Ensembl	ENST00000290209	ENSP00000290209; ENSG00000140199. [Q9UHW9-2]
# Ensembl	ENST00000354181	ENSP00000346112; ENSG00000140199. [Q9UHW9-1]
# Ensembl	ENST00000397702	ENSP00000380814; ENSG00000140199. [Q9UHW9-5]
# Ensembl	ENST00000397707	ENSP00000380819; ENSG00000140199. [Q9UHW9-3]
# Ensembl	ENST00000458406	ENSP00000387725; ENSG00000140199. [Q9UHW9-5]
# Ensembl	ENST00000558589	ENSP00000452776; ENSG00000140199. [Q9UHW9-4]
# Ensembl	ENST00000558667	ENSP00000453473; ENSG00000140199. [Q9UHW9-1]
# Ensembl	ENST00000560611	ENSP00000454168; ENSG00000140199. [Q9UHW9-1]
# ExpressionAtlas	Q9UHW9	baseline and differential
# FUNCTION	S12A6_HUMAN	Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IEA:InterPro.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0016323	basolateral plasma membrane; ISS:UniProtKB.
# GO_function	GO:0015079	potassium ion transmembrane transporter activity; IDA:ParkinsonsUK-UCL.
# GO_function	GO:0019901	protein kinase binding; IPI:ParkinsonsUK-UCL.
# GO_function	GO:0022820	potassium ion symporter activity; IBA:GO_Central.
# GO_function	GO:0035827	rubidium ion transmembrane transporter activity; IMP:ParkinsonsUK-UCL.
# GO_function	S12A6_HUMAN	GO 0015379 potassium chloride symporter activity; IDA UniProtKB.
# GO_process	GO:0001525	angiogenesis; NAS:UniProtKB.
# GO_process	GO:0006811	ion transport; IDA:UniProtKB.
# GO_process	GO:0007268	chemical synaptic transmission; IBA:GO_Central.
# GO_process	GO:0010107	potassium ion import; IDA:ParkinsonsUK-UCL.
# GO_process	GO:0035826	rubidium ion transport; IMP:ParkinsonsUK-UCL.
# GO_process	GO:0071476	cellular hypotonic response; IMP:ParkinsonsUK-UCL.
# GO_process	GO:0071477	cellular hypotonic salinity response; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0048646	anatomical structure formation involved in morphogenesis
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9UHW9	HS
# HGNC	HGNC:10914	SLC12A6
# INDUCTION	S12A6_HUMAN	Up-regulated by VEGF. Down-regulated by TNF. 
# IntAct	Q9UHW9	4
# InterPro	IPR000076	KCL_cotranspt
# InterPro	IPR004841	AA-permease/SLC12A_dom
# InterPro	IPR004842	SLC12A_fam
# InterPro	IPR018491	SLC12_C
# InterPro	IPR030364	KCC3
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H00816	[Neurodegenerative disease] Agenesis of the corpus callosum with peripheral neuropathy (ACCPN)
# MIM	218000	phenotype
# MIM	604878	gene
# Organism	S12A6_HUMAN	Homo sapiens (Human)
# Orphanet	1496	Corpus callosum agenesis - neuronopathy
# PANTHER	PTHR11827:SF66	PTHR11827:SF66; 4
# PIR	T17275	T17275
# PRINTS	PR01081	KCLTRNSPORT
# PTM	S12A6_HUMAN	N-glycosylated. {ECO 0000269|PubMed 10187864, ECO 0000269|PubMed 12368912}. 
# Pfam	PF00324	AA_permease; 2
# Pfam	PF03522	SLC12; 2
# Proteomes	UP000005640	Chromosome 15
# Reactome	R-HSA-426117	Cation-coupled Chloride cotransporters
# RecName	S12A6_HUMAN	Solute carrier family 12 member 6
# RefSeq	NP_001035959	NM_001042494.1. [Q9UHW9-5]
# RefSeq	NP_001035960	NM_001042495.1. [Q9UHW9-5]
# RefSeq	NP_001035961	NM_001042496.1. [Q9UHW9-4]
# RefSeq	NP_001035962	NM_001042497.1. [Q9UHW9-3]
# RefSeq	NP_005126	NM_005135.2. [Q9UHW9-2]
# RefSeq	NP_598408	NM_133647.1. [Q9UHW9-1]
# SIMILARITY	Belongs to the SLC12A transporter family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S12A6_HUMAN	Basolateral cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUBUNIT	Homomultimer and heteromultimer with other K-Cl cotransporters. {ECO	0000250}. 
# TCDB	2.A.30.5	the cation-chloride cotransporter (ccc) family
# TIGRFAMs	TIGR00930	2a30
# TISSUE SPECIFICITY	Highly expressed in heart, brain and kidney. Detected at lower levels in skeletal muscle, placenta, lung and pancreas. Detected in umbilical vein endothelial cells. Isoform 2 is more abundant in kidney. Isoform 5 is testis specific. Expressed in the proximal tubule of the kidney (at protein level). {ECO:0000269|PubMed	16048901}. 
# UCSC	uc001zhv	human. [Q9UHW9-1]
# eggNOG	COG0531	LUCA
# eggNOG	KOG2082	Eukaryota
BLAST	swissprot:S12A6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S12A6_HUMAN
BioCyc	ZFISH:ENSG00000140199-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000140199-MONOMER
COXPRESdb	9990	http://coxpresdb.jp/data/gene/9990.shtml
CleanEx	HS_SLC12A6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC12A6
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04601	http://dx.doi.org/10.1038/nature04601
DOI	10.1038/ng1002	http://dx.doi.org/10.1038/ng1002
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/jbc.274.15.10661	http://dx.doi.org/10.1074/jbc.274.15.10661
DOI	10.1074/jbc.274.23.16355	http://dx.doi.org/10.1074/jbc.274.23.16355
DOI	10.1074/jbc.M107155200	http://dx.doi.org/10.1074/jbc.M107155200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1152/ajpcell.00070.2011	http://dx.doi.org/10.1152/ajpcell.00070.2011
DOI	10.1152/ajprenal.00464.2004	http://dx.doi.org/10.1152/ajprenal.00464.2004
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DrugBank	DB00761	http://www.drugbank.ca/drugs/DB00761
EMBL	AC021822	http://www.ebi.ac.uk/ena/data/view/AC021822
EMBL	AC079203	http://www.ebi.ac.uk/ena/data/view/AC079203
EMBL	AF105366	http://www.ebi.ac.uk/ena/data/view/AF105366
EMBL	AF108831	http://www.ebi.ac.uk/ena/data/view/AF108831
EMBL	AF116242	http://www.ebi.ac.uk/ena/data/view/AF116242
EMBL	AF314931	http://www.ebi.ac.uk/ena/data/view/AF314931
EMBL	AF314932	http://www.ebi.ac.uk/ena/data/view/AF314932
EMBL	AF314933	http://www.ebi.ac.uk/ena/data/view/AF314933
EMBL	AF314933	http://www.ebi.ac.uk/ena/data/view/AF314933
EMBL	AF314934	http://www.ebi.ac.uk/ena/data/view/AF314934
EMBL	AF314934	http://www.ebi.ac.uk/ena/data/view/AF314934
EMBL	AF314935	http://www.ebi.ac.uk/ena/data/view/AF314935
EMBL	AF314935	http://www.ebi.ac.uk/ena/data/view/AF314935
EMBL	AF314936	http://www.ebi.ac.uk/ena/data/view/AF314936
EMBL	AF314936	http://www.ebi.ac.uk/ena/data/view/AF314936
EMBL	AF314937	http://www.ebi.ac.uk/ena/data/view/AF314937
EMBL	AF314937	http://www.ebi.ac.uk/ena/data/view/AF314937
EMBL	AF314938	http://www.ebi.ac.uk/ena/data/view/AF314938
EMBL	AF314938	http://www.ebi.ac.uk/ena/data/view/AF314938
EMBL	AF314939	http://www.ebi.ac.uk/ena/data/view/AF314939
EMBL	AF314939	http://www.ebi.ac.uk/ena/data/view/AF314939
EMBL	AF314940	http://www.ebi.ac.uk/ena/data/view/AF314940
EMBL	AF314940	http://www.ebi.ac.uk/ena/data/view/AF314940
EMBL	AF314941	http://www.ebi.ac.uk/ena/data/view/AF314941
EMBL	AF314941	http://www.ebi.ac.uk/ena/data/view/AF314941
EMBL	AF314942	http://www.ebi.ac.uk/ena/data/view/AF314942
EMBL	AF314942	http://www.ebi.ac.uk/ena/data/view/AF314942
EMBL	AF314943	http://www.ebi.ac.uk/ena/data/view/AF314943
EMBL	AF314943	http://www.ebi.ac.uk/ena/data/view/AF314943
EMBL	AF314944	http://www.ebi.ac.uk/ena/data/view/AF314944
EMBL	AF314944	http://www.ebi.ac.uk/ena/data/view/AF314944
EMBL	AF314945	http://www.ebi.ac.uk/ena/data/view/AF314945
EMBL	AF314945	http://www.ebi.ac.uk/ena/data/view/AF314945
EMBL	AF314946	http://www.ebi.ac.uk/ena/data/view/AF314946
EMBL	AF314946	http://www.ebi.ac.uk/ena/data/view/AF314946
EMBL	AF314947	http://www.ebi.ac.uk/ena/data/view/AF314947
EMBL	AF314947	http://www.ebi.ac.uk/ena/data/view/AF314947
EMBL	AF314948	http://www.ebi.ac.uk/ena/data/view/AF314948
EMBL	AF314948	http://www.ebi.ac.uk/ena/data/view/AF314948
EMBL	AF314949	http://www.ebi.ac.uk/ena/data/view/AF314949
EMBL	AF314949	http://www.ebi.ac.uk/ena/data/view/AF314949
EMBL	AF314950	http://www.ebi.ac.uk/ena/data/view/AF314950
EMBL	AF314950	http://www.ebi.ac.uk/ena/data/view/AF314950
EMBL	AF314951	http://www.ebi.ac.uk/ena/data/view/AF314951
EMBL	AF314951	http://www.ebi.ac.uk/ena/data/view/AF314951
EMBL	AF314952	http://www.ebi.ac.uk/ena/data/view/AF314952
EMBL	AF314952	http://www.ebi.ac.uk/ena/data/view/AF314952
EMBL	AF314953	http://www.ebi.ac.uk/ena/data/view/AF314953
EMBL	AF314953	http://www.ebi.ac.uk/ena/data/view/AF314953
EMBL	AF314954	http://www.ebi.ac.uk/ena/data/view/AF314954
EMBL	AF314954	http://www.ebi.ac.uk/ena/data/view/AF314954
EMBL	AF314955	http://www.ebi.ac.uk/ena/data/view/AF314955
EMBL	AF314955	http://www.ebi.ac.uk/ena/data/view/AF314955
EMBL	AF314956	http://www.ebi.ac.uk/ena/data/view/AF314956
EMBL	AF314956	http://www.ebi.ac.uk/ena/data/view/AF314956
EMBL	AF477977	http://www.ebi.ac.uk/ena/data/view/AF477977
EMBL	AF531258	http://www.ebi.ac.uk/ena/data/view/AF531258
EMBL	AF531259	http://www.ebi.ac.uk/ena/data/view/AF531259
EMBL	AF531260	http://www.ebi.ac.uk/ena/data/view/AF531260
EMBL	AK315283	http://www.ebi.ac.uk/ena/data/view/AK315283
EMBL	AL117500	http://www.ebi.ac.uk/ena/data/view/AL117500
EMBL	BC126241	http://www.ebi.ac.uk/ena/data/view/BC126241
EMBL	BC126243	http://www.ebi.ac.uk/ena/data/view/BC126243
EMBL	CH471125	http://www.ebi.ac.uk/ena/data/view/CH471125
EMBL	CH471125	http://www.ebi.ac.uk/ena/data/view/CH471125
EMBL	CH471125	http://www.ebi.ac.uk/ena/data/view/CH471125
EMBL	DQ138323	http://www.ebi.ac.uk/ena/data/view/DQ138323
Ensembl	ENST00000290209	http://www.ensembl.org/id/ENST00000290209
Ensembl	ENST00000354181	http://www.ensembl.org/id/ENST00000354181
Ensembl	ENST00000397702	http://www.ensembl.org/id/ENST00000397702
Ensembl	ENST00000397707	http://www.ensembl.org/id/ENST00000397707
Ensembl	ENST00000458406	http://www.ensembl.org/id/ENST00000458406
Ensembl	ENST00000558589	http://www.ensembl.org/id/ENST00000558589
Ensembl	ENST00000558667	http://www.ensembl.org/id/ENST00000558667
Ensembl	ENST00000560611	http://www.ensembl.org/id/ENST00000560611
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_function	GO:0015079	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015079
GO_function	GO:0015379	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015379
GO_function	GO:0019901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019901
GO_function	GO:0022820	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022820
GO_function	GO:0035827	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035827
GO_process	GO:0001525	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001525
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0010107	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010107
GO_process	GO:0035826	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035826
GO_process	GO:0071476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071476
GO_process	GO:0071477	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071477
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0048646	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048646
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC12A6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC12A6
GeneID	9990	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9990
GeneTree	ENSGT00760000119053	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119053
HGNC	HGNC:10914	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10914
HOGENOM	HOG000092644	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000092644&db=HOGENOM6
HOVERGEN	HBG052852	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052852&db=HOVERGEN
HPA	HPA034563	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA034563
InParanoid	Q9UHW9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UHW9
IntAct	Q9UHW9	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9UHW9*
InterPro	IPR000076	http://www.ebi.ac.uk/interpro/entry/IPR000076
InterPro	IPR004841	http://www.ebi.ac.uk/interpro/entry/IPR004841
InterPro	IPR004842	http://www.ebi.ac.uk/interpro/entry/IPR004842
InterPro	IPR018491	http://www.ebi.ac.uk/interpro/entry/IPR018491
InterPro	IPR030364	http://www.ebi.ac.uk/interpro/entry/IPR030364
Jabion	9990	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9990
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00816	http://www.genome.jp/dbget-bin/www_bget?H00816
KEGG_Gene	hsa:9990	http://www.genome.jp/dbget-bin/www_bget?hsa:9990
KEGG_Orthology	KO:K14427	http://www.genome.jp/dbget-bin/www_bget?KO:K14427
MIM	218000	http://www.ncbi.nlm.nih.gov/omim/218000
MIM	604878	http://www.ncbi.nlm.nih.gov/omim/604878
OMA	DRTSHPQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DRTSHPQ
Orphanet	1496	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1496
OrthoDB	EOG091G0WB4	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0WB4
PANTHER	PTHR11827:SF66	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11827:SF66
PRINTS	PR01081	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01081
PSORT	swissprot:S12A6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S12A6_HUMAN
PSORT-B	swissprot:S12A6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S12A6_HUMAN
PSORT2	swissprot:S12A6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S12A6_HUMAN
Pfam	PF00324	http://pfam.xfam.org/family/PF00324
Pfam	PF03522	http://pfam.xfam.org/family/PF03522
PharmGKB	PA35808	http://www.pharmgkb.org/do/serve?objId=PA35808&objCls=Gene
Phobius	swissprot:S12A6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S12A6_HUMAN
PhylomeDB	Q9UHW9	http://phylomedb.org/?seqid=Q9UHW9
ProteinModelPortal	Q9UHW9	http://www.proteinmodelportal.org/query/uniprot/Q9UHW9
PubMed	10187864	http://www.ncbi.nlm.nih.gov/pubmed/10187864
PubMed	10347194	http://www.ncbi.nlm.nih.gov/pubmed/10347194
PubMed	10600773	http://www.ncbi.nlm.nih.gov/pubmed/10600773
PubMed	11551954	http://www.ncbi.nlm.nih.gov/pubmed/11551954
PubMed	12368912	http://www.ncbi.nlm.nih.gov/pubmed/12368912
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16048901	http://www.ncbi.nlm.nih.gov/pubmed/16048901
PubMed	16572171	http://www.ncbi.nlm.nih.gov/pubmed/16572171
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	21613606	http://www.ncbi.nlm.nih.gov/pubmed/21613606
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
Reactome	R-HSA-426117	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-426117
RefSeq	NP_001035959	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001035959
RefSeq	NP_001035960	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001035960
RefSeq	NP_001035961	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001035961
RefSeq	NP_001035962	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001035962
RefSeq	NP_005126	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005126
RefSeq	NP_598408	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_598408
STRING	9606.ENSP00000452776	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000452776&targetmode=cogs
TCDB	2.A.30.5	http://www.tcdb.org/search/result.php?tc=2.A.30.5
TIGRFAMs	TIGR00930	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00930
UCSC	uc001zhv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001zhv&org=rat
UniGene	Hs.510939	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.510939
UniProtKB	S12A6_HUMAN	http://www.uniprot.org/uniprot/S12A6_HUMAN
UniProtKB-AC	Q9UHW9	http://www.uniprot.org/uniprot/Q9UHW9
charge	swissprot:S12A6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S12A6_HUMAN
eggNOG	COG0531	http://eggnogapi.embl.de/nog_data/html/tree/COG0531
eggNOG	KOG2082	http://eggnogapi.embl.de/nog_data/html/tree/KOG2082
epestfind	swissprot:S12A6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S12A6_HUMAN
garnier	swissprot:S12A6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S12A6_HUMAN
helixturnhelix	swissprot:S12A6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S12A6_HUMAN
hmoment	swissprot:S12A6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S12A6_HUMAN
iep	swissprot:S12A6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S12A6_HUMAN
inforesidue	swissprot:S12A6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S12A6_HUMAN
neXtProt	NX_Q9UHW9	http://www.nextprot.org/db/entry/NX_Q9UHW9
octanol	swissprot:S12A6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S12A6_HUMAN
pepcoil	swissprot:S12A6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S12A6_HUMAN
pepdigest	swissprot:S12A6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S12A6_HUMAN
pepinfo	swissprot:S12A6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S12A6_HUMAN
pepnet	swissprot:S12A6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S12A6_HUMAN
pepstats	swissprot:S12A6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S12A6_HUMAN
pepwheel	swissprot:S12A6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S12A6_HUMAN
pepwindow	swissprot:S12A6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S12A6_HUMAN
sigcleave	swissprot:S12A6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S12A6_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TRPV4_HUMAN	Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=A; IsoId=Q9HBA0-1; Sequence=Displayed; Name=2; Synonyms=B, OTRPC4beta; IsoId=Q9HBA0-2; Sequence=VSP_013436; Name=3; Synonyms=TRPV-SV; IsoId=Q9HBA0-3; Sequence=VSP_013437; Name=4; Synonyms=C; IsoId=Q9HBA0-4; Sequence=VSP_026615; Name=5; Synonyms=D; IsoId=Q9HBA0-5; Sequence=VSP_026614; Name=6; Synonyms=E; IsoId=Q9HBA0-6; Sequence=VSP_026615, VSP_013436; 
# AltName	TRPV4_HUMAN	Osm-9-like TRP channel 4
# AltName	TRPV4_HUMAN	Transient receptor potential protein 12
# AltName	TRPV4_HUMAN	Vanilloid receptor-like channel 2
# AltName	TRPV4_HUMAN	Vanilloid receptor-like protein 2
# AltName	TRPV4_HUMAN	Vanilloid receptor-related osmotically-activated channel
# BioGrid	121883	11
# CCDS	CCDS53827	-. [Q9HBA0-6]
# CCDS	CCDS53828	-. [Q9HBA0-4]
# CCDS	CCDS53829	-. [Q9HBA0-5]
# CCDS	CCDS9134	-. [Q9HBA0-1]
# CCDS	CCDS9135	-. [Q9HBA0-2]
# DISEASE	TRPV4_HUMAN	Brachyolmia 3 (BCYM3) [MIM 113500]  A form of brachyolmia, a clinically and genetically heterogeneous skeletal dysplasia primarily affecting the spine and characterized by a short trunk, short stature, and platyspondyly. BCYM3 is an autosomal dominant form with severe scoliosis with or without kyphosis, and flattened irregular cervical vertebrae. {ECO 0000269|PubMed 18587396}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	TRPV4_HUMAN	Charcot-Marie-Tooth disease 2C (CMT2C) [MIM 606071]  An axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology  primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. {ECO 0000269|PubMed 20037586, ECO 0000269|PubMed 20037587, ECO 0000269|PubMed 20037588, ECO 0000269|PubMed 21115951, ECO 0000269|PubMed 21288981}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	TRPV4_HUMAN	Digital arthropathy-brachydactyly, familial (FDAB) [MIM 606835]  A disorder characterized by irregularities in the proximal articular surfaces of the distal interphalangeal joints of the hand. Individuals appear normal at birth, with no clinical or radiographic evidence of a developmental skeletal dysplasia. The earliest changes appear during the first decade of life. By adulthood, all interphalangeal, metacarpophalangeal, and metatarsophalangeal joints are affected by a deforming, painful osteoarthritis. The remainder of the skeleton is clinically and radiographically unaffected. {ECO 0000269|PubMed 21964574}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	TRPV4_HUMAN	Metatropic dysplasia (MTD) [MIM 156530]  A severe spondyloepimetaphyseal dysplasia characterized by short limbs with limitation and enlargement of joints and usually severe kyphoscoliosis. Radiologic features include severe platyspondyly, severe metaphyseal enlargement and shortening of long bones. {ECO 0000269|PubMed 19232556, ECO 0000269|PubMed 20425821, ECO 0000269|PubMed 20577006, ECO 0000269|Ref.6}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	TRPV4_HUMAN	Neuronopathy, distal hereditary motor, 8 (HMN8) [MIM 600175]  A clinically variable, neuromuscular disorder characterized by congenital lower motor neuron disorder restricted to the lower part of the body. Clinical manifestations include non-progressive muscular atrophy, thigh muscle atrophy, weak thigh adductors, weak knee and foot extensors, minimal jaw muscle and neck flexor weakness, flexion contractures of knees and pes equinovarus. Tendon reflexes are normal. {ECO 0000269|PubMed 20037588, ECO 0000269|PubMed 22526352}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	TRPV4_HUMAN	Parastremmatic dwarfism (PSTD) [MIM 168400]  A bone dysplasia characterized by severe dwarfism, kyphoscoliosis, distortion and bowing of the extremities, and contractures of the large joints. Radiographically, the disease is characterized by a combination of decreased bone density, bowing of the long bones, platyspondyly and striking irregularities of endochondral ossification with areas of calcific stippling and streaking in radiolucent epiphyses, metaphyses and apophyses. {ECO 0000269|PubMed 20503319}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	TRPV4_HUMAN	Scapuloperoneal spinal muscular atrophy (SPSMA) [MIM 181405]  A clinically variable neuromuscular disorder characterized by neurogenic scapuloperoneal amyotrophy, laryngeal palsy, congenital absence of muscles, progressive scapuloperoneal atrophy and progressive distal weakness and amyotrophy. {ECO 0000269|PubMed 20037587}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	TRPV4_HUMAN	Spondyloepiphyseal dysplasia Maroteaux type (SEDM) [MIM 184095]  A clinically variable spondyloepiphyseal dysplasia with manifestations limited to the musculoskeletal system. Clinical features include short stature, brachydactyly, platyspondyly, short and stubby hands and feet, epiphyseal hypoplasia of the large joints, and iliac hypoplasia. Intelligence is normal. {ECO 0000269|PubMed 20503319}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	TRPV4_HUMAN	Spondylometaphyseal dysplasia Kozlowski type (SMDK) [MIM 184252]  A form of spondylometaphyseal dysplasia, a group of short stature disorders distinguished by abnormalities in the vertebrae and the metaphyses of the tubular bones. It is characterized by postnatal dwarfism, significant scoliosis and mild metaphyseal abnormalities in the pelvis. The vertebrae exhibit platyspondyly and overfaced pedicles. {ECO 0000269|PubMed 19232556, ECO 0000269|PubMed 20577006}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000261740	ENSP00000261740; ENSG00000111199. [Q9HBA0-1]
# Ensembl	ENST00000418703	ENSP00000406191; ENSG00000111199. [Q9HBA0-1]
# Ensembl	ENST00000536838	ENSP00000444336; ENSG00000111199. [Q9HBA0-5]
# Ensembl	ENST00000537083	ENSP00000442738; ENSG00000111199. [Q9HBA0-2]
# Ensembl	ENST00000541794	ENSP00000442167; ENSG00000111199. [Q9HBA0-4]
# Ensembl	ENST00000544971	ENSP00000443611; ENSG00000111199. [Q9HBA0-6]
# ExpressionAtlas	Q9HBA0	baseline and differential
# FUNCTION	TRPV4_HUMAN	Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed 18826956, PubMed 18695040). Also activated by heat, low pH, citrate and phorbol esters (PubMed 18826956, PubMed 18695040). Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (PubMed 12724311, PubMed 18826956). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (PubMed 19759329). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13- didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (PubMed 19759329). Together with PKD2, forms mechano- and thermosensitive channels in cilium (PubMed 18695040). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (By similarity). Regulates expression of chemokines and cytokines related to proinflammatory pathway in adipocytes (By similarity). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (By similarity). {ECO 0000250|UniProtKB Q9EPK8, ECO 0000269|PubMed 11025659, ECO 0000269|PubMed 12724311, ECO 0000269|PubMed 18695040, ECO 0000269|PubMed 18826956, ECO 0000269|PubMed 19759329}. 
# GO_component	GO:0005881	cytoplasmic microtubule; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0005912	adherens junction; ISS:UniProtKB.
# GO_component	GO:0005925	focal adhesion; ISS:BHF-UCL.
# GO_component	GO:0005929	cilium; IBA:GO_Central.
# GO_component	GO:0009986	cell surface; IEA:Ensembl.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0030027	lamellipodium; ISS:BHF-UCL.
# GO_component	GO:0030175	filopodium; ISS:BHF-UCL.
# GO_component	GO:0030426	growth cone; ISS:BHF-UCL.
# GO_component	GO:0030864	cortical actin cytoskeleton; ISS:BHF-UCL.
# GO_component	GO:0031410	cytoplasmic vesicle; IEA:Ensembl.
# GO_component	GO:0032587	ruffle membrane; ISS:BHF-UCL.
# GO_function	GO:0003779	actin binding; ISS:BHF-UCL.
# GO_function	GO:0005034	osmosensor activity; IEA:Ensembl.
# GO_function	GO:0005080	protein kinase C binding; ISS:BHF-UCL.
# GO_function	GO:0005261	cation channel activity; IDA:UniProtKB.
# GO_function	GO:0005262	calcium channel activity; IDA:UniProtKB.
# GO_function	GO:0005516	calmodulin binding; IMP:UniProtKB.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0008017	microtubule binding; ISS:BHF-UCL.
# GO_function	GO:0015275	stretch-activated, cation-selective, calcium channel activity; IMP:UniProtKB.
# GO_function	GO:0019901	protein kinase binding; IPI:BHF-UCL.
# GO_function	GO:0042169	SH2 domain binding; ISS:BHF-UCL.
# GO_function	GO:0043014	alpha-tubulin binding; ISS:BHF-UCL.
# GO_function	GO:0048487	beta-tubulin binding; ISS:BHF-UCL.
# GO_function	GO:0051015	actin filament binding; ISS:BHF-UCL.
# GO_process	GO:0000122	negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
# GO_process	GO:0002024	diet induced thermogenesis; IEA:Ensembl.
# GO_process	GO:0006816	calcium ion transport; IDA:UniProtKB.
# GO_process	GO:0006874	cellular calcium ion homeostasis; IDA:UniProtKB.
# GO_process	GO:0006884	cell volume homeostasis; TAS:UniProtKB.
# GO_process	GO:0007015	actin filament organization; ISS:BHF-UCL.
# GO_process	GO:0007043	cell-cell junction assembly; ISS:UniProtKB.
# GO_process	GO:0007204	positive regulation of cytosolic calcium ion concentration; IDA:UniProtKB.
# GO_process	GO:0007231	osmosensory signaling pathway; TAS:UniProtKB.
# GO_process	GO:0009612	response to mechanical stimulus; TAS:UniProtKB.
# GO_process	GO:0010628	positive regulation of gene expression; IEA:Ensembl.
# GO_process	GO:0010759	positive regulation of macrophage chemotaxis; IEA:Ensembl.
# GO_process	GO:0010977	negative regulation of neuron projection development; ISS:BHF-UCL.
# GO_process	GO:0030103	vasopressin secretion; IEA:Ensembl.
# GO_process	GO:0031117	positive regulation of microtubule depolymerization; ISS:BHF-UCL.
# GO_process	GO:0031532	actin cytoskeleton reorganization; ISS:BHF-UCL.
# GO_process	GO:0032868	response to insulin; IEA:Ensembl.
# GO_process	GO:0034605	cellular response to heat; ISS:UniProtKB.
# GO_process	GO:0042538	hyperosmotic salinity response; IEA:Ensembl.
# GO_process	GO:0042593	glucose homeostasis; IEA:Ensembl.
# GO_process	GO:0043117	positive regulation of vascular permeability; IMP:UniProtKB.
# GO_process	GO:0043622	cortical microtubule organization; ISS:BHF-UCL.
# GO_process	GO:0046330	positive regulation of JNK cascade; IEA:Ensembl.
# GO_process	GO:0046785	microtubule polymerization; ISS:BHF-UCL.
# GO_process	GO:0047484	regulation of response to osmotic stress; IEA:Ensembl.
# GO_process	GO:0050729	positive regulation of inflammatory response; IEA:Ensembl.
# GO_process	GO:0050891	multicellular organismal water homeostasis; IMP:UniProtKB.
# GO_process	GO:0070374	positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
# GO_process	GO:0070509	calcium ion import; ISS:BHF-UCL.
# GO_process	GO:0070588	calcium ion transmembrane transport; IMP:UniProtKB.
# GO_process	GO:0071470	cellular response to osmotic stress; ISS:UniProtKB.
# GO_process	GO:0071476	cellular hypotonic response; IMP:UniProtKB.
# GO_process	GO:0071477	cellular hypotonic salinity response; IEA:Ensembl.
# GO_process	GO:0071639	positive regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
# GO_process	GO:0071642	positive regulation of macrophage inflammatory protein 1 alpha production; IEA:Ensembl.
# GO_process	GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production; IEA:Ensembl.
# GO_process	GO:0097497	blood vessel endothelial cell delamination; IMP:UniProtKB.
# GO_process	GO:1903444	negative regulation of brown fat cell differentiation; IEA:Ensembl.
# GO_process	GO:1903759	signal transduction involved in regulation of aerobic respiration; IEA:Ensembl.
# GO_process	GO:2000340	positive regulation of chemokine (C-X-C motif) ligand 1 production; IEA:Ensembl.
# GO_process	GO:2000507	positive regulation of energy homeostasis; IEA:Ensembl.
# GO_process	GO:2000778	positive regulation of interleukin-6 secretion; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005856	cytoskeleton
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0005929	cilium
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0008092	cytoskeletal protein binding
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0003013	circulatory system process
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007010	cytoskeleton organization
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0022607	cellular component assembly
# GOslim_process	GO:0034330	cell junction organization
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.25.40.20	-; 1.
# Genevisible	Q9HBA0	HS
# HGNC	HGNC:18083	TRPV4
# IntAct	Q9HBA0	6
# InterPro	IPR002110	Ankyrin_rpt
# InterPro	IPR004729	TRP_channel
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR008347	TRPV1-4_channel
# InterPro	IPR008348	TRPV4_channel
# InterPro	IPR020683	Ankyrin_rpt-contain_dom
# KEGG_Brite	ko04040	Ion channels
# KEGG_Disease	H00455	[Neurodegenerative disease] SMA proximal adult autosomal dominant (SMAPAD)
# KEGG_Disease	H00522	[Skeletal dysplasia] Parastremmatic dysplasia
# KEGG_Disease	H00524	[Nervous system disease] Hereditary motor and sensory neuropathy type IIC (HMSN IIC)
# KEGG_Disease	H00856	[Nervous system disease] Distal hereditary motor neuropathies (dHMN)
# MIM	113500	phenotype
# MIM	156530	phenotype
# MIM	168400	phenotype
# MIM	181405	phenotype
# MIM	184095	phenotype
# MIM	184252	phenotype
# MIM	600175	phenotype
# MIM	605427	gene
# MIM	606071	phenotype
# MIM	606835	phenotype
# MIM	613508	phenotype
# Organism	TRPV4_HUMAN	Homo sapiens (Human)
# Orphanet	1216	Autosomal dominant congenital benign spinal muscular atrophy
# Orphanet	263482	Spondyloepiphyseal dysplasia, Maroteaux type
# Orphanet	2635	Metatropic dysplasia
# Orphanet	2646	Parastremmatic dwarfism
# Orphanet	85169	Familial digital arthropathy-brachydactyly
# Orphanet	93304	Autosomal dominant brachyolmia
# Orphanet	93314	Spondylometaphyseal dysplasia, Kozlowski type
# Orphanet	99937	Autosomal dominant Charcot-Marie-Tooth disease type 2C
# PANTHER	PTHR10582:SF4	PTHR10582:SF4; 2
# PDB	4DX1	X-ray; 2.85 A; A/B=149-397
# PDB	4DX2	X-ray; 2.95 A; A/B=149-397
# POLYMORPHISM	Genetic variations in TRPV4 determine the sodium serum level quantitative trait locus 1 (SSQTL1) [MIM	613508]. In some populations, variant Pro19Ser has been shown to be significantly associated with hyponatremia defined as serum sodium concentration below or equal to 135 mEq/L. 
# PRINTS	PR01768	TRPVRECEPTOR
# PRINTS	PR01769	VRL2RECEPTOR
# PROSITE	PS50088	ANK_REPEAT
# PROSITE	PS50297	ANK_REP_REGION
# Pfam	PF00023	Ank
# Pfam	PF00520	Ion_trans
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-3295583	TRP channels
# RecName	TRPV4_HUMAN	Transient receptor potential cation channel subfamily V member 4
# RefSeq	NP_001170899	NM_001177428.1. [Q9HBA0-4]
# RefSeq	NP_001170902	NM_001177431.1. [Q9HBA0-5]
# RefSeq	NP_001170904	NM_001177433.1. [Q9HBA0-6]
# RefSeq	NP_067638	NM_021625.4. [Q9HBA0-1]
# RefSeq	NP_671737	NM_147204.2. [Q9HBA0-2]
# RefSeq	XP_005253975	XM_005253918.1. [Q9HBA0-1]
# RefSeq	XP_016875263	XM_017019774.1. [Q9HBA0-1]
# SIMILARITY	Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV4 sub-subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 3 ANK repeats. {ECO:0000255|PROSITE- ProRule	PRU00023}.
# SMART	SM00248	ANK; 3
# SUBCELLULAR LOCATION	TRPV4_HUMAN	Apical cell membrane {ECO 0000269|PubMed 18695040, ECO 0000269|PubMed 18826956}; Multi- pass membrane protein. Cell junction, adherens junction {ECO 0000250|UniProtKB Q9EPK8}. Cell projection, cilium {ECO 0000269|PubMed 18695040}. Note=Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum. {ECO 0000269|PubMed 16293632, ECO 0000269|PubMed 20037587, ECO 0000269|PubMed 20037588}. 
# SUBCELLULAR LOCATION	TRPV4_HUMAN	Isoform 1  Cell membrane. 
# SUBCELLULAR LOCATION	TRPV4_HUMAN	Isoform 5  Cell membrane. 
# SUBUNIT	TRPV4_HUMAN	Homotetramer (Probable). Self-associates in a isoform- specific manner (PubMed 16293632). Isoforms 1/A and 5/D but not isoform 2/B, 4/C and 6/E can oligomerize (PubMed 16293632). Interacts with calmodulin (PubMed 12724311). Interacts with Map7 and Src family Tyr protein kinases LYN, SRC, FYN, HCK, LCK and YES (By similarity). Interacts with CTNNB1 (By similarity). The TRPV4 and CTNNB1 complex can interact with CDH1 (By similarity). Interacts with PACSIN1, PACSIN2 and PACSIN3 (via SH3 domain) (By similarity). Part of a complex containing MLC1, AQP4, HEPACAM and ATP1B1 (PubMed 22328087). Interacts with ITPR3 (PubMed 18826956). Interacts with AQP5; the interaction is probably indirect and regulates TRPV4 activation by hypotonicity (By similarity). Interacts with ANO1 (By similarity). Interacts (via C-terminus) with PKD2 (via C-terminus) (PubMed 18695040). {ECO 0000250|UniProtKB Q9EPK8, ECO 0000269|PubMed 12724311, ECO 0000269|PubMed 16293632, ECO 0000269|PubMed 18695040, ECO 0000269|PubMed 18826956, ECO 0000269|PubMed 22328087, ECO 0000269|PubMed 22702953, ECO 0000305}. 
# SUPFAM	SSF48403	SSF48403
# TIGRFAMs	TIGR00870	trp
# TISSUE SPECIFICITY	Found in the synoviocytes from patients with (RA) and without (CTR) rheumatoid arthritis (at protein level). {ECO:0000269|PubMed	19759329}. 
# UCSC	uc001tpg	human. [Q9HBA0-1]
# eggNOG	ENOG4110DG4	LUCA
# eggNOG	KOG3676	Eukaryota
BLAST	swissprot:TRPV4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TRPV4_HUMAN
COXPRESdb	59341	http://coxpresdb.jp/data/gene/59341.shtml
DIP	DIP-35702N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35702N
DOI	10.1002/ajmg.a.33392	http://dx.doi.org/10.1002/ajmg.a.33392
DOI	10.1002/ajmg.a.33414	http://dx.doi.org/10.1002/ajmg.a.33414
DOI	10.1007/s10048-012-0328-7	http://dx.doi.org/10.1007/s10048-012-0328-7
DOI	10.1016/S0092-8674(00)00143-4	http://dx.doi.org/10.1016/S0092-8674(00)00143-4
DOI	10.1016/j.ajhg.2009.01.021	http://dx.doi.org/10.1016/j.ajhg.2009.01.021
DOI	10.1021/bi300279b	http://dx.doi.org/10.1021/bi300279b
DOI	10.1038/35036318	http://dx.doi.org/10.1038/35036318
DOI	10.1038/ng.166	http://dx.doi.org/10.1038/ng.166
DOI	10.1038/ng.508	http://dx.doi.org/10.1038/ng.508
DOI	10.1038/ng.509	http://dx.doi.org/10.1038/ng.509
DOI	10.1038/ng.512	http://dx.doi.org/10.1038/ng.512
DOI	10.1038/ng.945	http://dx.doi.org/10.1038/ng.945
DOI	10.1073/pnas.0904084106	http://dx.doi.org/10.1073/pnas.0904084106
DOI	10.1074/jbc.C800184200	http://dx.doi.org/10.1074/jbc.C800184200
DOI	10.1074/jbc.M302561200	http://dx.doi.org/10.1074/jbc.M302561200
DOI	10.1074/jbc.M302590200	http://dx.doi.org/10.1074/jbc.M302590200
DOI	10.1074/jbc.M511456200	http://dx.doi.org/10.1074/jbc.M511456200
DOI	10.1083/jcb.200805124	http://dx.doi.org/10.1083/jcb.200805124
DOI	10.1093/hmg/dds032	http://dx.doi.org/10.1093/hmg/dds032
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1136/jmg.2009.075358	http://dx.doi.org/10.1136/jmg.2009.075358
DOI	10.1152/ajpcell.00204.2009	http://dx.doi.org/10.1152/ajpcell.00204.2009
DOI	10.1212/WNL.0b013e3181ffe4bb	http://dx.doi.org/10.1212/WNL.0b013e3181ffe4bb
DOI	10.1212/WNL.0b013e31820f2de3	http://dx.doi.org/10.1212/WNL.0b013e31820f2de3
EMBL	AB032427	http://www.ebi.ac.uk/ena/data/view/AB032427
EMBL	AB073669	http://www.ebi.ac.uk/ena/data/view/AB073669
EMBL	AB100308	http://www.ebi.ac.uk/ena/data/view/AB100308
EMBL	AF258465	http://www.ebi.ac.uk/ena/data/view/AF258465
EMBL	AF263523	http://www.ebi.ac.uk/ena/data/view/AF263523
EMBL	AF279673	http://www.ebi.ac.uk/ena/data/view/AF279673
EMBL	AJ296305	http://www.ebi.ac.uk/ena/data/view/AJ296305
EMBL	BC117426	http://www.ebi.ac.uk/ena/data/view/BC117426
EMBL	BC143315	http://www.ebi.ac.uk/ena/data/view/BC143315
EMBL	CH471054	http://www.ebi.ac.uk/ena/data/view/CH471054
EMBL	DQ059644	http://www.ebi.ac.uk/ena/data/view/DQ059644
EMBL	DQ059645	http://www.ebi.ac.uk/ena/data/view/DQ059645
EMBL	DQ059646	http://www.ebi.ac.uk/ena/data/view/DQ059646
Ensembl	ENST00000261740	http://www.ensembl.org/id/ENST00000261740
Ensembl	ENST00000418703	http://www.ensembl.org/id/ENST00000418703
Ensembl	ENST00000536838	http://www.ensembl.org/id/ENST00000536838
Ensembl	ENST00000537083	http://www.ensembl.org/id/ENST00000537083
Ensembl	ENST00000541794	http://www.ensembl.org/id/ENST00000541794
Ensembl	ENST00000544971	http://www.ensembl.org/id/ENST00000544971
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005881	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005881
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005912	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005912
GO_component	GO:0005925	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005925
GO_component	GO:0005929	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005929
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0030027	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030027
GO_component	GO:0030175	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030175
GO_component	GO:0030426	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030426
GO_component	GO:0030864	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030864
GO_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GO_component	GO:0032587	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032587
GO_function	GO:0003779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003779
GO_function	GO:0005034	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005034
GO_function	GO:0005080	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005080
GO_function	GO:0005261	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005261
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0005516	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005516
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0008017	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008017
GO_function	GO:0015275	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015275
GO_function	GO:0019901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019901
GO_function	GO:0042169	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042169
GO_function	GO:0043014	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043014
GO_function	GO:0048487	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048487
GO_function	GO:0051015	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051015
GO_process	GO:0000122	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000122
GO_process	GO:0002024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002024
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0006874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874
GO_process	GO:0006884	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006884
GO_process	GO:0007015	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007015
GO_process	GO:0007043	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007043
GO_process	GO:0007204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007204
GO_process	GO:0007231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007231
GO_process	GO:0009612	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009612
GO_process	GO:0010628	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010628
GO_process	GO:0010759	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010759
GO_process	GO:0010977	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010977
GO_process	GO:0030103	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030103
GO_process	GO:0031117	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031117
GO_process	GO:0031532	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031532
GO_process	GO:0032868	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032868
GO_process	GO:0034605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034605
GO_process	GO:0042538	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042538
GO_process	GO:0042593	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042593
GO_process	GO:0043117	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043117
GO_process	GO:0043622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043622
GO_process	GO:0046330	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046330
GO_process	GO:0046785	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046785
GO_process	GO:0047484	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047484
GO_process	GO:0050729	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050729
GO_process	GO:0050891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050891
GO_process	GO:0070374	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070374
GO_process	GO:0070509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070509
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:0071470	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071470
GO_process	GO:0071476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071476
GO_process	GO:0071477	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071477
GO_process	GO:0071639	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071639
GO_process	GO:0071642	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071642
GO_process	GO:0071651	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071651
GO_process	GO:0097497	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097497
GO_process	GO:1903444	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903444
GO_process	GO:1903759	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903759
GO_process	GO:2000340	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000340
GO_process	GO:2000507	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000507
GO_process	GO:2000778	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000778
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0005929	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005929
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0008092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0003013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003013
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007010
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0022607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607
GOslim_process	GO:0034330	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034330
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.25.40.20	http://www.cathdb.info/version/latest/superfamily/1.25.40.20
GeneCards	TRPV4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TRPV4
GeneID	59341	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=59341
GeneTree	ENSGT00550000074425	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074425
HGNC	HGNC:18083	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18083
HOVERGEN	HBG054085	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054085&db=HOVERGEN
HPA	HPA007150	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA007150
InParanoid	Q9HBA0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9HBA0
IntAct	Q9HBA0	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9HBA0*
InterPro	IPR002110	http://www.ebi.ac.uk/interpro/entry/IPR002110
InterPro	IPR004729	http://www.ebi.ac.uk/interpro/entry/IPR004729
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR008347	http://www.ebi.ac.uk/interpro/entry/IPR008347
InterPro	IPR008348	http://www.ebi.ac.uk/interpro/entry/IPR008348
InterPro	IPR020683	http://www.ebi.ac.uk/interpro/entry/IPR020683
Jabion	59341	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=59341
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00455	http://www.genome.jp/dbget-bin/www_bget?H00455
KEGG_Disease	H00522	http://www.genome.jp/dbget-bin/www_bget?H00522
KEGG_Disease	H00524	http://www.genome.jp/dbget-bin/www_bget?H00524
KEGG_Disease	H00856	http://www.genome.jp/dbget-bin/www_bget?H00856
KEGG_Gene	hsa:59341	http://www.genome.jp/dbget-bin/www_bget?hsa:59341
KEGG_Orthology	KO:K04973	http://www.genome.jp/dbget-bin/www_bget?KO:K04973
MIM	113500	http://www.ncbi.nlm.nih.gov/omim/113500
MIM	156530	http://www.ncbi.nlm.nih.gov/omim/156530
MIM	168400	http://www.ncbi.nlm.nih.gov/omim/168400
MIM	181405	http://www.ncbi.nlm.nih.gov/omim/181405
MIM	184095	http://www.ncbi.nlm.nih.gov/omim/184095
MIM	184252	http://www.ncbi.nlm.nih.gov/omim/184252
MIM	600175	http://www.ncbi.nlm.nih.gov/omim/600175
MIM	605427	http://www.ncbi.nlm.nih.gov/omim/605427
MIM	606071	http://www.ncbi.nlm.nih.gov/omim/606071
MIM	606835	http://www.ncbi.nlm.nih.gov/omim/606835
MIM	613508	http://www.ncbi.nlm.nih.gov/omim/613508
MINT	MINT-4535111	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4535111
OMA	KSETYQY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KSETYQY
Orphanet	1216	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1216
Orphanet	263482	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=263482
Orphanet	2635	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=2635
Orphanet	2646	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=2646
Orphanet	85169	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=85169
Orphanet	93304	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=93304
Orphanet	93314	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=93314
Orphanet	99937	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=99937
OrthoDB	EOG091G016O	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G016O
PANTHER	PTHR10582:SF4	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10582:SF4
PDB	4DX1	http://www.ebi.ac.uk/pdbe-srv/view/entry/4DX1
PDB	4DX2	http://www.ebi.ac.uk/pdbe-srv/view/entry/4DX2
PDBsum	4DX1	http://www.ebi.ac.uk/pdbsum/4DX1
PDBsum	4DX2	http://www.ebi.ac.uk/pdbsum/4DX2
PRINTS	PR01768	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01768
PRINTS	PR01769	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01769
PROSITE	PS50088	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50088
PROSITE	PS50297	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50297
PSORT	swissprot:TRPV4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TRPV4_HUMAN
PSORT-B	swissprot:TRPV4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TRPV4_HUMAN
PSORT2	swissprot:TRPV4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TRPV4_HUMAN
Pfam	PF00023	http://pfam.xfam.org/family/PF00023
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
PharmGKB	PA38293	http://www.pharmgkb.org/do/serve?objId=PA38293&objCls=Gene
Phobius	swissprot:TRPV4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TRPV4_HUMAN
PhylomeDB	Q9HBA0	http://phylomedb.org/?seqid=Q9HBA0
ProteinModelPortal	Q9HBA0	http://www.proteinmodelportal.org/query/uniprot/Q9HBA0
PubMed	11025659	http://www.ncbi.nlm.nih.gov/pubmed/11025659
PubMed	11081638	http://www.ncbi.nlm.nih.gov/pubmed/11081638
PubMed	12692122	http://www.ncbi.nlm.nih.gov/pubmed/12692122
PubMed	12724311	http://www.ncbi.nlm.nih.gov/pubmed/12724311
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16293632	http://www.ncbi.nlm.nih.gov/pubmed/16293632
PubMed	18587396	http://www.ncbi.nlm.nih.gov/pubmed/18587396
PubMed	18695040	http://www.ncbi.nlm.nih.gov/pubmed/18695040
PubMed	18826956	http://www.ncbi.nlm.nih.gov/pubmed/18826956
PubMed	19232556	http://www.ncbi.nlm.nih.gov/pubmed/19232556
PubMed	19666518	http://www.ncbi.nlm.nih.gov/pubmed/19666518
PubMed	19759329	http://www.ncbi.nlm.nih.gov/pubmed/19759329
PubMed	20037586	http://www.ncbi.nlm.nih.gov/pubmed/20037586
PubMed	20037587	http://www.ncbi.nlm.nih.gov/pubmed/20037587
PubMed	20037588	http://www.ncbi.nlm.nih.gov/pubmed/20037588
PubMed	20425821	http://www.ncbi.nlm.nih.gov/pubmed/20425821
PubMed	20503319	http://www.ncbi.nlm.nih.gov/pubmed/20503319
PubMed	20577006	http://www.ncbi.nlm.nih.gov/pubmed/20577006
PubMed	21115951	http://www.ncbi.nlm.nih.gov/pubmed/21115951
PubMed	21288981	http://www.ncbi.nlm.nih.gov/pubmed/21288981
PubMed	21964574	http://www.ncbi.nlm.nih.gov/pubmed/21964574
PubMed	22328087	http://www.ncbi.nlm.nih.gov/pubmed/22328087
PubMed	22526352	http://www.ncbi.nlm.nih.gov/pubmed/22526352
PubMed	22702953	http://www.ncbi.nlm.nih.gov/pubmed/22702953
Reactome	R-HSA-3295583	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3295583
RefSeq	NP_001170899	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001170899
RefSeq	NP_001170902	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001170902
RefSeq	NP_001170904	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001170904
RefSeq	NP_067638	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_067638
RefSeq	NP_671737	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_671737
RefSeq	XP_005253975	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005253975
RefSeq	XP_016875263	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016875263
SMART	SM00248	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00248
SMR	Q9HBA0	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9HBA0
STRING	9606.ENSP00000261740	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000261740&targetmode=cogs
SUPFAM	SSF48403	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48403
TIGRFAMs	TIGR00870	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00870
UCSC	uc001tpg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001tpg&org=rat
UniGene	Hs.506713	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.506713
UniProtKB	TRPV4_HUMAN	http://www.uniprot.org/uniprot/TRPV4_HUMAN
UniProtKB-AC	Q9HBA0	http://www.uniprot.org/uniprot/Q9HBA0
charge	swissprot:TRPV4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TRPV4_HUMAN
eggNOG	ENOG4110DG4	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110DG4
eggNOG	KOG3676	http://eggnogapi.embl.de/nog_data/html/tree/KOG3676
epestfind	swissprot:TRPV4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TRPV4_HUMAN
garnier	swissprot:TRPV4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TRPV4_HUMAN
helixturnhelix	swissprot:TRPV4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRPV4_HUMAN
hmoment	swissprot:TRPV4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TRPV4_HUMAN
iep	swissprot:TRPV4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TRPV4_HUMAN
inforesidue	swissprot:TRPV4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TRPV4_HUMAN
neXtProt	NX_Q9HBA0	http://www.nextprot.org/db/entry/NX_Q9HBA0
octanol	swissprot:TRPV4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TRPV4_HUMAN
pepcoil	swissprot:TRPV4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TRPV4_HUMAN
pepdigest	swissprot:TRPV4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TRPV4_HUMAN
pepinfo	swissprot:TRPV4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TRPV4_HUMAN
pepnet	swissprot:TRPV4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TRPV4_HUMAN
pepstats	swissprot:TRPV4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TRPV4_HUMAN
pepwheel	swissprot:TRPV4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TRPV4_HUMAN
pepwindow	swissprot:TRPV4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TRPV4_HUMAN
sigcleave	swissprot:TRPV4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TRPV4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CNNM2_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9H8M5-1; Sequence=Displayed; Name=2; IsoId=Q9H8M5-2; Sequence=VSP_027080; Name=3; IsoId=Q9H8M5-3; Sequence=VSP_027077, VSP_027078; Note=No experimental confirmation available.; 
# AltName	CNNM2_HUMAN	Ancient conserved domain-containing protein 2
# AltName	CNNM2_HUMAN	Cyclin-M2
# BioGrid	120162	5
# CCDS	CCDS44474	-. [Q9H8M5-1]
# CCDS	CCDS44475	-. [Q9H8M5-2]
# CCDS	CCDS7543	-. [Q9H8M5-3]
# ChiTaRS	CNNM2	human
# DISEASE	CNNM2_HUMAN	Hypomagnesemia 6 (HOMG6) [MIM 613882]  A renal disease characterized by severely lowered serum magnesium levels in the absence of other electrolyte disturbances. Affected individuals show an inappropriately normal urinary magnesium excretion, demonstrating a defect in tubular reabsorption. Age of clinical onset is highly variable and some affected individuals are asymptomatic. {ECO 0000269|PubMed 21397062}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CNNM2_HUMAN	Hypomagnesemia, seizures, and mental retardation (HOMGSMR) [MIM 616418]  A disease characterized by renal wasting of magnesium, low serum magnesium, seizures, and variable degrees of delayed psychomotor development. {ECO 0000269|PubMed 24699222}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000369875	ENSP00000358891; ENSG00000148842. [Q9H8M5-3]
# Ensembl	ENST00000369878	ENSP00000358894; ENSG00000148842. [Q9H8M5-1]
# Ensembl	ENST00000433628	ENSP00000392875; ENSG00000148842. [Q9H8M5-2]
# FUNCTION	CNNM2_HUMAN	Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). {ECO 0000250|UniProtKB Q3TWN3}. 
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0016323	basolateral plasma membrane; IMP:MGI.
# GO_function	GO:0005524	ATP binding; IEA:Ensembl.
# GO_function	GO:0015095	magnesium ion transmembrane transporter activity; IEA:Ensembl.
# GO_process	GO:0010960	magnesium ion homeostasis; IMP:MGI.
# GO_process	GO:0015693	magnesium ion transport; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0042592	homeostatic process
# Gene3D	2.60.120.10	-; 2.
# Genevisible	Q9H8M5	HS
# HGNC	HGNC:103	CNNM2
# InterPro	IPR000644	CBS_dom
# InterPro	IPR002550	DUF21
# InterPro	IPR014710	RmlC-like_jellyroll
# KEGG_Brite	ko02000	Transporters
# MIM	607803	gene
# MIM	613882	phenotype
# MIM	616418	phenotype
# MISCELLANEOUS	CNNM2_HUMAN	Shares weak sequence similarity with the cyclin family, hence its name. However, it has no cyclin-like function in vivo. 
# Organism	CNNM2_HUMAN	Homo sapiens (Human)
# Orphanet	34527	Familial primary hypomagnesemia with normocalciuria and normocalcemia
# PDB	4IY0	X-ray; 1.90 A; A=429-584
# PDB	4IY2	X-ray; 3.60 A; A/C=430-584
# PDB	4IY4	X-ray; 2.90 A; A/C=429-584
# PDB	4IYS	X-ray; 1.80 A; A=430-584
# PROSITE	PS51371	CBS; 2
# Pfam	PF00571	CBS
# Pfam	PF01595	DUF21
# Proteomes	UP000005640	Chromosome 10
# RecName	CNNM2_HUMAN	Metal transporter CNNM2
# RefSeq	NP_060119	NM_017649.4. [Q9H8M5-1]
# RefSeq	NP_951058	NM_199076.2. [Q9H8M5-2]
# RefSeq	NP_951059	NM_199077.2. [Q9H8M5-3]
# SEQUENCE CAUTION	CNNM2_HUMAN	Sequence=AAF86374.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=BAA90926.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=BAB14386.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=CAI16511.1; Type=Erroneous gene model prediction; Evidence={ECO 0000305}; Sequence=CAI16512.1; Type=Erroneous gene model prediction; Evidence={ECO 0000305}; Sequence=CAI40076.1; Type=Erroneous gene model prediction; Evidence={ECO 0000305}; Sequence=CAI40077.1; Type=Erroneous gene model prediction; Evidence={ECO 0000305};
# SIMILARITY	Belongs to the ACDP family. {ECO	0000305}. 
# SIMILARITY	Contains 1 DUF21 domain. {ECO	0000305}. 
# SIMILARITY	Contains 2 CBS domains. {ECO:0000255|PROSITE- ProRule	PRU00703}. 
# SUBCELLULAR LOCATION	CNNM2_HUMAN	Cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# TISSUE SPECIFICITY	Widely expressed. Expressed at higher level in brain, kidney and placenta, while it is weakly expressed in skeletal muscle. In the kidney, it is expressed in the distal convoluted tubule and the thick ascending limb of Henle loop. {ECO:0000269|PubMed	21397062}. 
# UCSC	uc001kwl	human. [Q9H8M5-1]
# eggNOG	COG1253	LUCA
# eggNOG	KOG2118	Eukaryota
BLAST	swissprot:CNNM2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CNNM2_HUMAN
COXPRESdb	54805	http://coxpresdb.jp/data/gene/54805.shtml
CleanEx	HS_CNNM2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CNNM2
DOI	10.1016/S0378-1119(02)01210-6	http://dx.doi.org/10.1016/S0378-1119(02)01210-6
DOI	10.1016/j.ajhg.2011.02.005	http://dx.doi.org/10.1016/j.ajhg.2011.02.005
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature02462	http://dx.doi.org/10.1038/nature02462
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1371/journal.pgen.1004267	http://dx.doi.org/10.1371/journal.pgen.1004267
EMBL	AF216962	http://www.ebi.ac.uk/ena/data/view/AF216962
EMBL	AK000071	http://www.ebi.ac.uk/ena/data/view/AK000071
EMBL	AK023066	http://www.ebi.ac.uk/ena/data/view/AK023066
EMBL	AK023479	http://www.ebi.ac.uk/ena/data/view/AK023479
EMBL	AL139817	http://www.ebi.ac.uk/ena/data/view/AL139817
EMBL	AL139817	http://www.ebi.ac.uk/ena/data/view/AL139817
EMBL	AL139817	http://www.ebi.ac.uk/ena/data/view/AL139817
EMBL	AL139817	http://www.ebi.ac.uk/ena/data/view/AL139817
EMBL	AL356608	http://www.ebi.ac.uk/ena/data/view/AL356608
EMBL	AL356608	http://www.ebi.ac.uk/ena/data/view/AL356608
EMBL	AL356608	http://www.ebi.ac.uk/ena/data/view/AL356608
EMBL	AL356608	http://www.ebi.ac.uk/ena/data/view/AL356608
EMBL	AL356608	http://www.ebi.ac.uk/ena/data/view/AL356608
EMBL	BC021222	http://www.ebi.ac.uk/ena/data/view/BC021222
Ensembl	ENST00000369875	http://www.ensembl.org/id/ENST00000369875
Ensembl	ENST00000369878	http://www.ensembl.org/id/ENST00000369878
Ensembl	ENST00000433628	http://www.ensembl.org/id/ENST00000433628
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0015095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015095
GO_process	GO:0010960	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010960
GO_process	GO:0015693	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015693
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
Gene3D	2.60.120.10	http://www.cathdb.info/version/latest/superfamily/2.60.120.10
GeneCards	CNNM2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CNNM2
GeneID	54805	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54805
GeneTree	ENSGT00390000002383	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002383
H-InvDB	HIX0009171	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0009171
HGNC	HGNC:103	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:103
HOVERGEN	HBG074775	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG074775&db=HOVERGEN
HPA	HPA059954	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA059954
InParanoid	Q9H8M5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9H8M5
IntAct	Q9H8M5	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9H8M5*
InterPro	IPR000644	http://www.ebi.ac.uk/interpro/entry/IPR000644
InterPro	IPR002550	http://www.ebi.ac.uk/interpro/entry/IPR002550
InterPro	IPR014710	http://www.ebi.ac.uk/interpro/entry/IPR014710
Jabion	54805	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=54805
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:54805	http://www.genome.jp/dbget-bin/www_bget?hsa:54805
KEGG_Orthology	KO:K16302	http://www.genome.jp/dbget-bin/www_bget?KO:K16302
MIM	607803	http://www.ncbi.nlm.nih.gov/omim/607803
MIM	613882	http://www.ncbi.nlm.nih.gov/omim/613882
MIM	616418	http://www.ncbi.nlm.nih.gov/omim/616418
OMA	VMASRMD	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VMASRMD
Orphanet	34527	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=34527
OrthoDB	EOG091G02YS	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02YS
PDB	4IY0	http://www.ebi.ac.uk/pdbe-srv/view/entry/4IY0
PDB	4IY2	http://www.ebi.ac.uk/pdbe-srv/view/entry/4IY2
PDB	4IY4	http://www.ebi.ac.uk/pdbe-srv/view/entry/4IY4
PDB	4IYS	http://www.ebi.ac.uk/pdbe-srv/view/entry/4IYS
PDBsum	4IY0	http://www.ebi.ac.uk/pdbsum/4IY0
PDBsum	4IY2	http://www.ebi.ac.uk/pdbsum/4IY2
PDBsum	4IY4	http://www.ebi.ac.uk/pdbsum/4IY4
PDBsum	4IYS	http://www.ebi.ac.uk/pdbsum/4IYS
PROSITE	PS51371	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51371
PSORT	swissprot:CNNM2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CNNM2_HUMAN
PSORT-B	swissprot:CNNM2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CNNM2_HUMAN
PSORT2	swissprot:CNNM2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CNNM2_HUMAN
Pfam	PF00571	http://pfam.xfam.org/family/PF00571
Pfam	PF01595	http://pfam.xfam.org/family/PF01595
PharmGKB	PA26669	http://www.pharmgkb.org/do/serve?objId=PA26669&objCls=Gene
Phobius	swissprot:CNNM2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CNNM2_HUMAN
PhylomeDB	Q9H8M5	http://phylomedb.org/?seqid=Q9H8M5
ProteinModelPortal	Q9H8M5	http://www.proteinmodelportal.org/query/uniprot/Q9H8M5
PubMed	12657465	http://www.ncbi.nlm.nih.gov/pubmed/12657465
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15164054	http://www.ncbi.nlm.nih.gov/pubmed/15164054
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21397062	http://www.ncbi.nlm.nih.gov/pubmed/21397062
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24699222	http://www.ncbi.nlm.nih.gov/pubmed/24699222
RefSeq	NP_060119	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060119
RefSeq	NP_951058	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_951058
RefSeq	NP_951059	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_951059
SMR	Q9H8M5	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9H8M5
STRING	9606.ENSP00000358894	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000358894&targetmode=cogs
UCSC	uc001kwl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001kwl&org=rat
UniGene	Hs.643509	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.643509
UniProtKB	CNNM2_HUMAN	http://www.uniprot.org/uniprot/CNNM2_HUMAN
UniProtKB-AC	Q9H8M5	http://www.uniprot.org/uniprot/Q9H8M5
charge	swissprot:CNNM2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CNNM2_HUMAN
eggNOG	COG1253	http://eggnogapi.embl.de/nog_data/html/tree/COG1253
eggNOG	KOG2118	http://eggnogapi.embl.de/nog_data/html/tree/KOG2118
epestfind	swissprot:CNNM2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CNNM2_HUMAN
garnier	swissprot:CNNM2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CNNM2_HUMAN
helixturnhelix	swissprot:CNNM2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CNNM2_HUMAN
hmoment	swissprot:CNNM2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CNNM2_HUMAN
iep	swissprot:CNNM2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CNNM2_HUMAN
inforesidue	swissprot:CNNM2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CNNM2_HUMAN
neXtProt	NX_Q9H8M5	http://www.nextprot.org/db/entry/NX_Q9H8M5
octanol	swissprot:CNNM2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CNNM2_HUMAN
pepcoil	swissprot:CNNM2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CNNM2_HUMAN
pepdigest	swissprot:CNNM2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CNNM2_HUMAN
pepinfo	swissprot:CNNM2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CNNM2_HUMAN
pepnet	swissprot:CNNM2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CNNM2_HUMAN
pepstats	swissprot:CNNM2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CNNM2_HUMAN
pepwheel	swissprot:CNNM2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CNNM2_HUMAN
pepwindow	swissprot:CNNM2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CNNM2_HUMAN
sigcleave	swissprot:CNNM2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CNNM2_HUMAN
## Database	ID	URL or Descriptions
# AltName	MFS10_HUMAN	Tetracycline transporter-like protein
# BioGrid	115521	5
# CDD	cd06174	MFS
# ChiTaRS	MFSD10	human
# Ensembl	ENST00000329687	ENSP00000332646; ENSG00000109736
# Ensembl	ENST00000355443	ENSP00000347619; ENSG00000109736
# ExpressionAtlas	Q14728	baseline and differential
# FUNCTION	MFS10_HUMAN	Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump. {ECO 0000269|PubMed 17362938}. 
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_component	GO:0030659	cytoplasmic vesicle membrane; IDA:MGI.
# GO_component	GO:0031526	brush border membrane; IBA:GO_Central.
# GO_function	GO:0008493	tetracycline transporter activity; TAS:ProtInc.
# GO_function	GO:0008514	organic anion transmembrane transporter activity; IDA:MGI.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006915	apoptotic process; IEA:UniProtKB-KW.
# GO_process	GO:0043252	sodium-independent organic anion transport; IDA:MGI.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008219	cell death
# Genevisible	Q14728	HS
# HGNC	HGNC:16894	MFSD10
# IntAct	Q14728	4
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# MIM	610977	gene
# Organism	MFS10_HUMAN	Homo sapiens (Human)
# PIR	I54353	I54353
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 4
# RecName	MFS10_HUMAN	Major facilitator superfamily domain-containing protein 10
# RefSeq	NP_001111	NM_001120.4
# RefSeq	NP_001139541	NM_001146069.1
# SIMILARITY	Belongs to the major facilitator superfamily. {ECO	0000255}.
# SUBCELLULAR LOCATION	MFS10_HUMAN	Membrane {ECO 0000255}; Multi-pass membrane protein {ECO 0000255}. 
# SUPFAM	SSF103473	SSF103473; 2
# UCSC	uc003gfw	human
# eggNOG	ENOG410XSE0	LUCA
# eggNOG	KOG2615	Eukaryota
BLAST	swissprot:MFS10_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MFS10_HUMAN
COXPRESdb	10227	http://coxpresdb.jp/data/gene/10227.shtml
CleanEx	HS_MFSD10	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_MFSD10
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.febslet.2007.03.001	http://dx.doi.org/10.1016/j.febslet.2007.03.001
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1093/hmg/2.6.673	http://dx.doi.org/10.1093/hmg/2.6.673
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AL390065	http://www.ebi.ac.uk/ena/data/view/AL390065
EMBL	BC001502	http://www.ebi.ac.uk/ena/data/view/BC001502
EMBL	BC014979	http://www.ebi.ac.uk/ena/data/view/BC014979
EMBL	CH471131	http://www.ebi.ac.uk/ena/data/view/CH471131
EMBL	L11669	http://www.ebi.ac.uk/ena/data/view/L11669
Ensembl	ENST00000329687	http://www.ensembl.org/id/ENST00000329687
Ensembl	ENST00000355443	http://www.ensembl.org/id/ENST00000355443
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030659
GO_component	GO:0031526	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031526
GO_function	GO:0008493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008493
GO_function	GO:0008514	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008514
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006915	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006915
GO_process	GO:0043252	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043252
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219
GeneCards	MFSD10	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=MFSD10
GeneID	10227	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10227
GeneTree	ENSGT00830000128422	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00830000128422
HGNC	HGNC:16894	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16894
HOGENOM	HOG000209369	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000209369&db=HOGENOM6
HOVERGEN	HBG053800	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053800&db=HOVERGEN
HPA	HPA037398	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA037398
HPA	HPA043209	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA043209
InParanoid	Q14728	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q14728
IntAct	Q14728	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q14728*
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	10227	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10227
KEGG_Gene	hsa:10227	http://www.genome.jp/dbget-bin/www_bget?hsa:10227
MIM	610977	http://www.ncbi.nlm.nih.gov/omim/610977
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:MFS10_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MFS10_HUMAN
PSORT-B	swissprot:MFS10_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MFS10_HUMAN
PSORT2	swissprot:MFS10_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MFS10_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA162395840	http://www.pharmgkb.org/do/serve?objId=PA162395840&objCls=Gene
Phobius	swissprot:MFS10_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MFS10_HUMAN
PhylomeDB	Q14728	http://phylomedb.org/?seqid=Q14728
ProteinModelPortal	Q14728	http://www.proteinmodelportal.org/query/uniprot/Q14728
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	17362938	http://www.ncbi.nlm.nih.gov/pubmed/17362938
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	8353488	http://www.ncbi.nlm.nih.gov/pubmed/8353488
RefSeq	NP_001111	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001111
RefSeq	NP_001139541	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001139541
STRING	9606.ENSP00000332646	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000332646&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
UCSC	uc003gfw	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003gfw&org=rat
UniGene	Hs.632581	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.632581
UniProtKB	MFS10_HUMAN	http://www.uniprot.org/uniprot/MFS10_HUMAN
UniProtKB-AC	Q14728	http://www.uniprot.org/uniprot/Q14728
charge	swissprot:MFS10_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MFS10_HUMAN
eggNOG	ENOG410XSE0	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSE0
eggNOG	KOG2615	http://eggnogapi.embl.de/nog_data/html/tree/KOG2615
epestfind	swissprot:MFS10_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MFS10_HUMAN
garnier	swissprot:MFS10_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MFS10_HUMAN
helixturnhelix	swissprot:MFS10_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MFS10_HUMAN
hmoment	swissprot:MFS10_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MFS10_HUMAN
iep	swissprot:MFS10_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MFS10_HUMAN
inforesidue	swissprot:MFS10_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MFS10_HUMAN
neXtProt	NX_Q14728	http://www.nextprot.org/db/entry/NX_Q14728
octanol	swissprot:MFS10_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MFS10_HUMAN
pepcoil	swissprot:MFS10_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MFS10_HUMAN
pepdigest	swissprot:MFS10_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MFS10_HUMAN
pepinfo	swissprot:MFS10_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MFS10_HUMAN
pepnet	swissprot:MFS10_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MFS10_HUMAN
pepstats	swissprot:MFS10_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MFS10_HUMAN
pepwheel	swissprot:MFS10_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MFS10_HUMAN
pepwindow	swissprot:MFS10_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MFS10_HUMAN
sigcleave	swissprot:MFS10_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MFS10_HUMAN
## Database	ID	URL or Descriptions
# AltName	S6A19_HUMAN	Solute carrier family 6 member 19
# AltName	S6A19_HUMAN	System B(0) neutral amino acid transporter AT1
# ChiTaRS	SLC6A19	human
# DISEASE	S6A19_HUMAN	Hartnup disorder (HND) [MIM 234500]  Autosomal recessive abnormality of renal and gastrointestinal neutral amino acid transport noted for its clinical variability. First described in 1956, HND is characterized by increases in the urinary and intestinal excretion of neutral amino acids. Individuals with typical Hartnup aminoaciduria may be asymptomatic, some develop a photosensitive pellagra-like rash, attacks of cerebellar ataxia and other neurological or psychiatric features. Although the definition of HND was originally based on clinical and biochemical abnormalities, its marked clinical heterogeneity has led to it being known as a disorder with a consistent pathognomonic neutral hyperaminoaciduria. {ECO 0000269|PubMed 15286787, ECO 0000269|PubMed 15286788}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	S6A19_HUMAN	Hyperglycinuria (HG) [MIM 138500]  A condition characterized by excess of glycine in the urine. In some cases it is associated with renal colic and renal oxalate stones. {ECO 0000269|PubMed 19033659}. Note=The disease may be caused by mutations affecting the gene represented in this entry. SLC6A19 deficiency combined with haploinsufficiency of SLC6A20 or partially inactivating mutations in SLC36A2, can be responsible for hyperglycinuria. 
# DISEASE	S6A19_HUMAN	Iminoglycinuria (IG) [MIM 242600]  A disorder of renal tubular reabsorption of glycine and imino acids (proline and hydroxyproline), marked by excessive levels of all three substances in the urine. {ECO 0000269|PubMed 19033659}. Note=The disease may be caused by mutations affecting the gene represented in this entry. SLC6A19 deficiency combined with haploinsufficiency of SLC6A20 or partially inactivating mutations in SLC36A2, can be responsible for iminoglycinuria. Additional polymorphisms and mutations in SLC6A18 can contribute to the IG phenotype in some families. 
# Ensembl	ENST00000304460	ENSP00000305302; ENSG00000174358
# ExpressionAtlas	Q695T7	baseline and differential
# FUNCTION	S6A19_HUMAN	Transporter that mediates epithelial resorption of neutral amino acids across the apical membrane of epithelial cells in the kidney and intestine. It appears that leucine is the preferred substrate, but all large neutral non-aromatic L-amino acids bind to this transporter. Uptake of leucine is sodium- dependent. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity). {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0031526	brush border membrane; IEA:Ensembl.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015175	neutral amino acid transmembrane transporter activity; IBA:GO_Central.
# GO_function	S6A19_HUMAN	GO 0005328 neurotransmitter sodium symporter activity; IEA InterPro.
# GO_process	GO:0006865	amino acid transport; TAS:Reactome.
# GO_process	GO:0007584	response to nutrient; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q695T7	HS
# HGNC	HGNC:27960	SLC6A19
# InterPro	IPR000175	Na/ntran_symport
# InterPro	IPR002438	Na/ntran_symport_orphan
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00843	[Inherited metabolic disease] Hartnup disorder
# KEGG_Disease	H00905	[Urinary system disease; Kidney disease; Inherited metabolic disease] Iminoglycinuria
# KEGG_Disease	H01304	[Kidney disease] Hyperglycinuria
# KEGG_Pathway	ko04974	Protein digestion and absorption
# KEGG_Pathway	ko04978	Mineral absorption
# MIM	138500	phenotype
# MIM	234500	phenotype
# MIM	242600	phenotype
# MIM	608893	gene
# Organism	S6A19_HUMAN	Homo sapiens (Human)
# Orphanet	2116	Hartnup disease
# Orphanet	42062	Iminoglycinuria
# PANTHER	PTHR11616	PTHR11616; 2
# PRINTS	PR00176	NANEUSMPORT
# PRINTS	PR01206	ORPHTRNSPORT
# PROSITE	PS00610	NA_NEUROTRAN_SYMP_1
# PROSITE	PS50267	NA_NEUROTRAN_SYMP_3
# Pfam	PF00209	SNF
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-352230	Amino acid transport across the plasma membrane
# Reactome	R-HSA-442660	Na+/Cl- dependent neurotransmitter transporters
# RecName	S6A19_HUMAN	Sodium-dependent neutral amino acid transporter B(0)AT1
# RefSeq	NP_001003841	NM_001003841.2
# SIMILARITY	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A19 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	S6A19_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	2.A.22.6:the neurotransmitter	sodium symporter (nss) family
# TISSUE SPECIFICITY	S6A19_HUMAN	Robust expression in kidney and small intestine, with minimal expression in pancreas. Also expressed in stomach, liver, duodenum, ileocecum, colon and prostate. Not detected in testis, whole brain, cerebellum, fetal liver, spleen, skeletal muscle, uterus, heart or lung. {ECO 0000269|PubMed 15286787, ECO 0000269|PubMed 15286788}. 
# UCSC	uc003jbw	human
# eggNOG	COG0733	LUCA
# eggNOG	KOG3659	Eukaryota
BLAST	swissprot:S6A19_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S6A19_HUMAN
COXPRESdb	340024	http://coxpresdb.jp/data/gene/340024.shtml
CleanEx	HS_SLC6A19	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC6A19
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/ng1405	http://dx.doi.org/10.1038/ng1405
DOI	10.1038/ng1406	http://dx.doi.org/10.1038/ng1406
DOI	10.1172/JCI36625	http://dx.doi.org/10.1172/JCI36625
EMBL	AK290811	http://www.ebi.ac.uk/ena/data/view/AK290811
EMBL	AY591756	http://www.ebi.ac.uk/ena/data/view/AY591756
EMBL	AY596807	http://www.ebi.ac.uk/ena/data/view/AY596807
EMBL	CH471102	http://www.ebi.ac.uk/ena/data/view/CH471102
Ensembl	ENST00000304460	http://www.ensembl.org/id/ENST00000304460
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0031526	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031526
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005328
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_function	GO:0015175	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015175
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GO_process	GO:0007584	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007584
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	SLC6A19	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC6A19
GeneID	340024	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=340024
GeneTree	ENSGT00760000119044	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119044
HGNC	HGNC:27960	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:27960
HOGENOM	HOG000116406	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116406&db=HOGENOM6
HOVERGEN	HBG071421	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG071421&db=HOVERGEN
HPA	HPA037415	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA037415
HPA	HPA043207	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA043207
InParanoid	Q695T7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q695T7
InterPro	IPR000175	http://www.ebi.ac.uk/interpro/entry/IPR000175
InterPro	IPR002438	http://www.ebi.ac.uk/interpro/entry/IPR002438
Jabion	340024	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=340024
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00843	http://www.genome.jp/dbget-bin/www_bget?H00843
KEGG_Disease	H00905	http://www.genome.jp/dbget-bin/www_bget?H00905
KEGG_Disease	H01304	http://www.genome.jp/dbget-bin/www_bget?H01304
KEGG_Gene	hsa:340024	http://www.genome.jp/dbget-bin/www_bget?hsa:340024
KEGG_Orthology	KO:K05334	http://www.genome.jp/dbget-bin/www_bget?KO:K05334
KEGG_Pathway	ko04974	http://www.genome.jp/kegg-bin/show_pathway?ko04974
KEGG_Pathway	ko04978	http://www.genome.jp/kegg-bin/show_pathway?ko04978
MIM	138500	http://www.ncbi.nlm.nih.gov/omim/138500
MIM	234500	http://www.ncbi.nlm.nih.gov/omim/234500
MIM	242600	http://www.ncbi.nlm.nih.gov/omim/242600
MIM	608893	http://www.ncbi.nlm.nih.gov/omim/608893
OMA	GYVDECA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GYVDECA
Orphanet	2116	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=2116
Orphanet	42062	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=42062
OrthoDB	EOG091G08PX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08PX
PANTHER	PTHR11616	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11616
PRINTS	PR00176	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00176
PRINTS	PR01206	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01206
PROSITE	PS00610	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00610
PROSITE	PS50267	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50267
PSORT	swissprot:S6A19_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S6A19_HUMAN
PSORT-B	swissprot:S6A19_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S6A19_HUMAN
PSORT2	swissprot:S6A19_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S6A19_HUMAN
Pfam	PF00209	http://pfam.xfam.org/family/PF00209
PharmGKB	PA134968815	http://www.pharmgkb.org/do/serve?objId=PA134968815&objCls=Gene
Phobius	swissprot:S6A19_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S6A19_HUMAN
PhylomeDB	Q695T7	http://phylomedb.org/?seqid=Q695T7
ProteinModelPortal	Q695T7	http://www.proteinmodelportal.org/query/uniprot/Q695T7
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15286787	http://www.ncbi.nlm.nih.gov/pubmed/15286787
PubMed	15286788	http://www.ncbi.nlm.nih.gov/pubmed/15286788
PubMed	19033659	http://www.ncbi.nlm.nih.gov/pubmed/19033659
Reactome	R-HSA-352230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-352230
Reactome	R-HSA-442660	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442660
RefSeq	NP_001003841	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001003841
STRING	9606.ENSP00000305302	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000305302&targetmode=cogs
TCDB	2.A.22.6	http://www.tcdb.org/search/result.php?tc=2.A.22.6
UCSC	uc003jbw	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003jbw&org=rat
UniGene	Hs.481478	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.481478
UniProtKB	S6A19_HUMAN	http://www.uniprot.org/uniprot/S6A19_HUMAN
UniProtKB-AC	Q695T7	http://www.uniprot.org/uniprot/Q695T7
charge	swissprot:S6A19_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S6A19_HUMAN
eggNOG	COG0733	http://eggnogapi.embl.de/nog_data/html/tree/COG0733
eggNOG	KOG3659	http://eggnogapi.embl.de/nog_data/html/tree/KOG3659
epestfind	swissprot:S6A19_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S6A19_HUMAN
garnier	swissprot:S6A19_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S6A19_HUMAN
helixturnhelix	swissprot:S6A19_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S6A19_HUMAN
hmoment	swissprot:S6A19_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S6A19_HUMAN
iep	swissprot:S6A19_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S6A19_HUMAN
inforesidue	swissprot:S6A19_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S6A19_HUMAN
neXtProt	NX_Q695T7	http://www.nextprot.org/db/entry/NX_Q695T7
octanol	swissprot:S6A19_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S6A19_HUMAN
pepcoil	swissprot:S6A19_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S6A19_HUMAN
pepdigest	swissprot:S6A19_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S6A19_HUMAN
pepinfo	swissprot:S6A19_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S6A19_HUMAN
pepnet	swissprot:S6A19_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S6A19_HUMAN
pepstats	swissprot:S6A19_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S6A19_HUMAN
pepwheel	swissprot:S6A19_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S6A19_HUMAN
pepwindow	swissprot:S6A19_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S6A19_HUMAN
sigcleave	swissprot:S6A19_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S6A19_HUMAN
## Database	ID	URL or Descriptions
# AltName	HEPS_HUMAN	Transmembrane protease serine 1
# AltName	HEPS_HUMAN	Transmembrane protease serine 1
# BRENDA	3.4.21.106	2681
# CATALYTIC ACTIVITY	HEPS_HUMAN	Cleavage after basic amino-acid residues, with Arg strongly preferred to Lys. {ECO 0000269|PubMed 15839837, ECO 0000269|PubMed 21875933, ECO 0000305|PubMed 26673890}. 
# CDD	cd00190	Tryp_SPc
# DrugBank	DB00036	Coagulation factor VIIa
# Ensembl	ENST00000262626	ENSP00000262626; ENSG00000105707
# Ensembl	ENST00000392226	ENSP00000376060; ENSG00000105707
# ExpressionAtlas	P05981	baseline and differential
# FUNCTION	HEPS_HUMAN	Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed 21875933, PubMed 15839837). Plays a role in cell growth and maintenance of cell morphology (PubMed 8346233, PubMed 21875933). Plays a role in the proteolytic processing of ACE2 (PubMed 24227843). Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed 26673890). {ECO 0000269|PubMed 15839837, ECO 0000269|PubMed 21875933, ECO 0000269|PubMed 24227843, ECO 0000269|PubMed 26673890, ECO 0000269|PubMed 8346233}. 
# GO_component	GO:0005789	endoplasmic reticulum membrane; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005911	cell-cell junction; ISS:UniProtKB.
# GO_component	GO:0009986	cell surface; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IDA:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0043025	neuronal cell body; ISS:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0004252	serine-type endopeptidase activity; IDA:UniProtKB.
# GO_function	GO:0008233	peptidase activity; IDA:UniProtKB.
# GO_function	GO:0008236	serine-type peptidase activity; IDA:UniProtKB.
# GO_function	GO:0015269	calcium-activated potassium channel activity; ISS:UniProtKB.
# GO_function	GO:0070008	serine-type exopeptidase activity; IEA:InterPro.
# GO_process	GO:0006508	proteolysis; IDA:UniProtKB.
# GO_process	GO:0008360	regulation of cell shape; IMP:UniProtKB.
# GO_process	GO:0010628	positive regulation of gene expression; ISS:UniProtKB.
# GO_process	GO:0010719	negative regulation of epithelial to mesenchymal transition; IDA:UniProtKB.
# GO_process	GO:0010756	positive regulation of plasminogen activation; IDA:UniProtKB.
# GO_process	GO:0030307	positive regulation of cell growth; IMP:UniProtKB.
# GO_process	GO:0034769	basement membrane disassembly; IDA:UniProtKB.
# GO_process	GO:0043066	negative regulation of apoptotic process; IDA:UniProtKB.
# GO_process	GO:0043923	positive regulation by host of viral transcription; IDA:UniProtKB.
# GO_process	GO:0048012	hepatocyte growth factor receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0050680	negative regulation of epithelial cell proliferation; IDA:UniProtKB.
# GO_process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound; ISS:UniProtKB.
# GO_process	GO:0071805	potassium ion transmembrane transport; ISS:UniProtKB.
# GO_process	GO:0090103	cochlea morphogenesis; ISS:UniProtKB.
# GO_process	GO:0097066	response to thyroid hormone; ISS:UniProtKB.
# GO_process	GO:0097195	pilomotor reflex; ISS:UniProtKB.
# GO_process	GO:2000347	positive regulation of hepatocyte proliferation; IDA:UniProtKB.
# GO_process	GO:2000611	positive regulation of thyroid hormone generation; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0008233	peptidase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0030198	extracellular matrix organization
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.10.250.10	-; 1.
# Genevisible	P05981	HS
# HGNC	HGNC:5155	HPN
# InterPro	IPR001254	Trypsin_dom
# InterPro	IPR001314	Peptidase_S1A
# InterPro	IPR009003	Peptidase_S1_PA
# InterPro	IPR015352	Hepsin-SRCR_dom
# InterPro	IPR017448	SRCR-like_dom
# InterPro	IPR018114	TRYPSIN_HIS
# InterPro	IPR033116	TRYPSIN_SER
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Brite	ko01002	 Peptidases
# KEGG_Pathway	ko05203	Viral carcinogenesis
# MIM	142440	gene
# Organism	HEPS_HUMAN	Homo sapiens (Human)
# PDB	1O5E	X-ray; 1.75 A; H=163-417, L=46-159
# PDB	1O5F	X-ray; 1.78 A; H=163-417, L=46-159
# PDB	1P57	X-ray; 1.75 A; A=46-159, B=163-417
# PDB	1Z8G	X-ray; 1.55 A; A=46-417
# PDB	3T2N	X-ray; 2.55 A; A/B=46-417
# PDB	5CE1	X-ray; 2.50 A; A=46-417
# PIR	S00845	S00845
# PRINTS	PR00722	CHYMOTRYPSIN
# PROSITE	PS00134	TRYPSIN_HIS
# PROSITE	PS00135	TRYPSIN_SER
# PROSITE	PS50240	TRYPSIN_DOM
# Pfam	PF00089	Trypsin
# Pfam	PF09272	Hepsin-SRCR
# ProDom	PD021735	Hepsin-SRCR
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-6806942	MET Receptor Activation
# Reactome	R-HSA-8852405	Signaling by MST1
# RecName	HEPS_HUMAN	Serine protease hepsin
# RecName	HEPS_HUMAN	Serine protease hepsin catalytic chain
# RecName	HEPS_HUMAN	Serine protease hepsin non-catalytic chain
# RecName	HEPS_HUMAN	Serine protease hepsin non-catalytic chain
# RefSeq	NP_002142	NM_002151.2
# RefSeq	NP_892028	NM_182983.2
# RefSeq	XP_005258895	XM_005258838.4
# RefSeq	XP_006723244	XM_006723181.3
# RefSeq	XP_016882220	XM_017026731.1
# SIMILARITY	Belongs to the peptidase S1 family. {ECO:0000255|PROSITE-ProRule	PRU00274}. 
# SIMILARITY	Contains 1 SRCR domain. {ECO	0000305}.
# SIMILARITY	Contains 1 peptidase S1 domain. {ECO:0000255|PROSITE- ProRule	PRU00274}. 
# SMART	SM00020	Tryp_SPc
# SMART	SM00202	SR
# SUBCELLULAR LOCATION	HEPS_HUMAN	Cell membrane {ECO 0000269|PubMed 1885621}; Single-pass type II membrane protein {ECO 0000269|PubMed 1885621}. Apical cell membrane {ECO 0000269|PubMed 26673890}; Single-pass type II membrane protein {ECO 0000305}. 
# SUPFAM	SSF50494	SSF50494
# SUPFAM	SSF56487	SSF56487
# TISSUE SPECIFICITY	Detected in liver and kidney. {ECO:0000269|PubMed	21875933}. 
# UCSC	uc002nxq	human
# eggNOG	COG5640	LUCA
# eggNOG	KOG3627	Eukaryota
BLAST	swissprot:HEPS_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:HEPS_HUMAN
BioCyc	ZFISH:HS02801-MONOMER	http://biocyc.org/getid?id=ZFISH:HS02801-MONOMER
COXPRESdb	3249	http://coxpresdb.jp/data/gene/3249.shtml
CleanEx	HS_HPN	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_HPN
DOI	10.1016/S0969-2126(03)00148-5	http://dx.doi.org/10.1016/S0969-2126(03)00148-5
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/bi00403a032	http://dx.doi.org/10.1021/bi00403a032
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/BJ20041955	http://dx.doi.org/10.1042/BJ20041955
DOI	10.1073/pnas.90.15.7181	http://dx.doi.org/10.1073/pnas.90.15.7181
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1128/JVI.02202-13	http://dx.doi.org/10.1128/JVI.02202-13
DOI	10.1158/1541-7786.MCR-11-0004	http://dx.doi.org/10.1158/1541-7786.MCR-11-0004
DOI	10.7554/eLife.08887	http://dx.doi.org/10.7554/eLife.08887
DrugBank	DB00036	http://www.drugbank.ca/drugs/DB00036
EC_number	EC:3.4.21.106 {ECO:0000269|PubMed:15839837, ECO:0000269|PubMed:21875933, ECO:0000305|PubMed:26673890}	http://www.genome.jp/dbget-bin/www_bget?EC:3.4.21.106 {ECO:0000269|PubMed:15839837, ECO:0000269|PubMed:21875933, ECO:0000305|PubMed:26673890}
EMBL	AK315655	http://www.ebi.ac.uk/ena/data/view/AK315655
EMBL	BC025716	http://www.ebi.ac.uk/ena/data/view/BC025716
EMBL	M18930	http://www.ebi.ac.uk/ena/data/view/M18930
EMBL	X07002	http://www.ebi.ac.uk/ena/data/view/X07002
EMBL	X07732	http://www.ebi.ac.uk/ena/data/view/X07732
ENZYME	3.4.21.106 {ECO:0000269|PubMed:15839837, ECO:0000269|PubMed:21875933, ECO:0000305|PubMed:26673890}	http://enzyme.expasy.org/EC/3.4.21.106 {ECO:0000269|PubMed:15839837, ECO:0000269|PubMed:21875933, ECO:0000305|PubMed:26673890}
Ensembl	ENST00000262626	http://www.ensembl.org/id/ENST00000262626
Ensembl	ENST00000392226	http://www.ensembl.org/id/ENST00000392226
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005911	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005911
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0004252	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004252
GO_function	GO:0008233	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233
GO_function	GO:0008236	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008236
GO_function	GO:0015269	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015269
GO_function	GO:0070008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070008
GO_process	GO:0006508	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006508
GO_process	GO:0008360	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360
GO_process	GO:0010628	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010628
GO_process	GO:0010719	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010719
GO_process	GO:0010756	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010756
GO_process	GO:0030307	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030307
GO_process	GO:0034769	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034769
GO_process	GO:0043066	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043066
GO_process	GO:0043923	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043923
GO_process	GO:0048012	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048012
GO_process	GO:0050680	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050680
GO_process	GO:0050910	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050910
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GO_process	GO:0090103	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090103
GO_process	GO:0097066	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097066
GO_process	GO:0097195	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097195
GO_process	GO:2000347	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000347
GO_process	GO:2000611	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000611
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0008233	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0030198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030198
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.10.250.10	http://www.cathdb.info/version/latest/superfamily/3.10.250.10
GeneCards	HPN	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=HPN
GeneID	3249	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3249
GeneTree	ENSGT00760000118962	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118962
H-InvDB	HIX0137465	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0137465
HGNC	HGNC:5155	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:5155
HOGENOM	HOG000251822	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000251822&db=HOGENOM6
HOVERGEN	HBG013304	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG013304&db=HOVERGEN
HPA	HPA006804	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA006804
InParanoid	P05981	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P05981
IntEnz	3.4.21.106 {ECO:0000269|PubMed:15839837, ECO:0000269|PubMed:21875933, ECO:0000305|PubMed:26673890}	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.21.106 {ECO:0000269|PubMed:15839837, ECO:0000269|PubMed:21875933, ECO:0000305|PubMed:26673890}
InterPro	IPR001254	http://www.ebi.ac.uk/interpro/entry/IPR001254
InterPro	IPR001314	http://www.ebi.ac.uk/interpro/entry/IPR001314
InterPro	IPR009003	http://www.ebi.ac.uk/interpro/entry/IPR009003
InterPro	IPR015352	http://www.ebi.ac.uk/interpro/entry/IPR015352
InterPro	IPR017448	http://www.ebi.ac.uk/interpro/entry/IPR017448
InterPro	IPR018114	http://www.ebi.ac.uk/interpro/entry/IPR018114
InterPro	IPR033116	http://www.ebi.ac.uk/interpro/entry/IPR033116
Jabion	3249	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3249
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Brite	ko01002	http://www.genome.jp/dbget-bin/www_bget?ko01002
KEGG_Gene	hsa:3249	http://www.genome.jp/dbget-bin/www_bget?hsa:3249
KEGG_Orthology	KO:K08665	http://www.genome.jp/dbget-bin/www_bget?KO:K08665
KEGG_Pathway	ko05203	http://www.genome.jp/kegg-bin/show_pathway?ko05203
MIM	142440	http://www.ncbi.nlm.nih.gov/omim/142440
OMA	CEEMGFI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CEEMGFI
OrthoDB	EOG091G0AH5	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0AH5
PDB	1O5E	http://www.ebi.ac.uk/pdbe-srv/view/entry/1O5E
PDB	1O5F	http://www.ebi.ac.uk/pdbe-srv/view/entry/1O5F
PDB	1P57	http://www.ebi.ac.uk/pdbe-srv/view/entry/1P57
PDB	1Z8G	http://www.ebi.ac.uk/pdbe-srv/view/entry/1Z8G
PDB	3T2N	http://www.ebi.ac.uk/pdbe-srv/view/entry/3T2N
PDB	5CE1	http://www.ebi.ac.uk/pdbe-srv/view/entry/5CE1
PDBsum	1O5E	http://www.ebi.ac.uk/pdbsum/1O5E
PDBsum	1O5F	http://www.ebi.ac.uk/pdbsum/1O5F
PDBsum	1P57	http://www.ebi.ac.uk/pdbsum/1P57
PDBsum	1Z8G	http://www.ebi.ac.uk/pdbsum/1Z8G
PDBsum	3T2N	http://www.ebi.ac.uk/pdbsum/3T2N
PDBsum	5CE1	http://www.ebi.ac.uk/pdbsum/5CE1
PRINTS	PR00722	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00722
PROSITE	PS00134	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00134
PROSITE	PS00135	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00135
PROSITE	PS50240	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50240
PSORT	swissprot:HEPS_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:HEPS_HUMAN
PSORT-B	swissprot:HEPS_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:HEPS_HUMAN
PSORT2	swissprot:HEPS_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:HEPS_HUMAN
Pfam	PF00089	http://pfam.xfam.org/family/PF00089
Pfam	PF09272	http://pfam.xfam.org/family/PF09272
PharmGKB	PA29425	http://www.pharmgkb.org/do/serve?objId=PA29425&objCls=Gene
Phobius	swissprot:HEPS_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:HEPS_HUMAN
PhylomeDB	P05981	http://phylomedb.org/?seqid=P05981
ProteinModelPortal	P05981	http://www.proteinmodelportal.org/query/uniprot/P05981
PubMed	12962630	http://www.ncbi.nlm.nih.gov/pubmed/12962630
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15839837	http://www.ncbi.nlm.nih.gov/pubmed/15839837
PubMed	1885621	http://www.ncbi.nlm.nih.gov/pubmed/1885621
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	21875933	http://www.ncbi.nlm.nih.gov/pubmed/21875933
PubMed	24227843	http://www.ncbi.nlm.nih.gov/pubmed/24227843
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	26673890	http://www.ncbi.nlm.nih.gov/pubmed/26673890
PubMed	2835076	http://www.ncbi.nlm.nih.gov/pubmed/2835076
PubMed	8346233	http://www.ncbi.nlm.nih.gov/pubmed/8346233
Reactome	R-HSA-6806942	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6806942
Reactome	R-HSA-8852405	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8852405
RefSeq	NP_002142	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002142
RefSeq	NP_892028	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_892028
RefSeq	XP_005258895	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005258895
RefSeq	XP_006723244	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006723244
RefSeq	XP_016882220	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016882220
SMART	SM00020	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00020
SMART	SM00202	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00202
SMR	P05981	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P05981
STRING	9606.ENSP00000262626	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000262626&targetmode=cogs
SUPFAM	SSF50494	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50494
SUPFAM	SSF56487	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56487
UCSC	uc002nxq	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002nxq&org=rat
UniGene	Hs.182385	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.182385
UniProtKB	HEPS_HUMAN	http://www.uniprot.org/uniprot/HEPS_HUMAN
UniProtKB-AC	P05981	http://www.uniprot.org/uniprot/P05981
charge	swissprot:HEPS_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:HEPS_HUMAN
eggNOG	COG5640	http://eggnogapi.embl.de/nog_data/html/tree/COG5640
eggNOG	KOG3627	http://eggnogapi.embl.de/nog_data/html/tree/KOG3627
epestfind	swissprot:HEPS_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:HEPS_HUMAN
garnier	swissprot:HEPS_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:HEPS_HUMAN
helixturnhelix	swissprot:HEPS_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:HEPS_HUMAN
hmoment	swissprot:HEPS_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:HEPS_HUMAN
iep	swissprot:HEPS_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:HEPS_HUMAN
inforesidue	swissprot:HEPS_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:HEPS_HUMAN
neXtProt	NX_P05981	http://www.nextprot.org/db/entry/NX_P05981
octanol	swissprot:HEPS_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:HEPS_HUMAN
pepcoil	swissprot:HEPS_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:HEPS_HUMAN
pepdigest	swissprot:HEPS_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:HEPS_HUMAN
pepinfo	swissprot:HEPS_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:HEPS_HUMAN
pepnet	swissprot:HEPS_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:HEPS_HUMAN
pepstats	swissprot:HEPS_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:HEPS_HUMAN
pepwheel	swissprot:HEPS_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:HEPS_HUMAN
pepwindow	swissprot:HEPS_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:HEPS_HUMAN
sigcleave	swissprot:HEPS_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:HEPS_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	125109	22
# ChiTaRS	SFXN5	human
# Ensembl	ENST00000272433	ENSP00000272433; ENSG00000144040
# ExpressionAtlas	Q8TD22	baseline and differential
# FUNCTION	SFXN5_HUMAN	Transports citrate. Potential iron transporter (By similarity). {ECO 0000250}. 
# GO_component	GO:0005743	mitochondrial inner membrane; IEA:Ensembl.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015137	citrate transmembrane transporter activity; IEA:Ensembl.
# GO_process	GO:0055072	iron ion homeostasis; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0042592	homeostatic process
# Genevisible	Q8TD22	HS
# HGNC	HGNC:16073	SFXN5
# InterPro	IPR004686	Mtc
# MIM	615572	gene
# Organism	SFXN5_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11153	PTHR11153
# Pfam	PF03820	Mtc
# Proteomes	UP000005640	Chromosome 2
# RecName	SFXN5_HUMAN	Sideroflexin-5
# RefSeq	NP_653180	NM_144579.2
# SIMILARITY	Belongs to the sideroflexin family. {ECO	0000305}.
# SUBCELLULAR LOCATION	SFXN5_HUMAN	Mitochondrion membrane {ECO 0000250}; Multi- pass membrane protein {ECO 0000250}. 
# TIGRFAMs	TIGR00798	mtc
# TISSUE SPECIFICITY	Primarily expressed in the brain. {ECO:0000269|PubMed	12039050}. 
# UCSC	uc002siq	human
# eggNOG	ENOG410YU8V	LUCA
# eggNOG	KOG3767	Eukaryota
BLAST	swissprot:SFXN5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SFXN5_HUMAN
BioCyc	ZFISH:ENSG00000144040-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000144040-MONOMER
COXPRESdb	94097	http://coxpresdb.jp/data/gene/94097.shtml
CleanEx	HS_SFXN5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SFXN5
DOI	10.1016/S0378-1119(02)00402-X	http://dx.doi.org/10.1016/S0378-1119(02)00402-X
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC012366	http://www.ebi.ac.uk/ena/data/view/AC012366
EMBL	AK289731	http://www.ebi.ac.uk/ena/data/view/AK289731
EMBL	AY044437	http://www.ebi.ac.uk/ena/data/view/AY044437
EMBL	BC101311	http://www.ebi.ac.uk/ena/data/view/BC101311
EMBL	BC101312	http://www.ebi.ac.uk/ena/data/view/BC101312
EMBL	BC101313	http://www.ebi.ac.uk/ena/data/view/BC101313
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
Ensembl	ENST00000272433	http://www.ensembl.org/id/ENST00000272433
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015137	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015137
GO_process	GO:0055072	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GeneCards	SFXN5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SFXN5
GeneID	94097	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=94097
GeneTree	ENSGT00390000002026	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002026
HGNC	HGNC:16073	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16073
HOGENOM	HOG000203440	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000203440&db=HOGENOM6
HOVERGEN	HBG056083	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG056083&db=HOVERGEN
HPA	HPA015473	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA015473
HPA	HPA056866	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA056866
InParanoid	Q8TD22	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8TD22
InterPro	IPR004686	http://www.ebi.ac.uk/interpro/entry/IPR004686
Jabion	94097	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=94097
KEGG_Gene	hsa:94097	http://www.genome.jp/dbget-bin/www_bget?hsa:94097
MIM	615572	http://www.ncbi.nlm.nih.gov/omim/615572
OMA	AIMETAF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AIMETAF
OrthoDB	EOG091G0C6A	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0C6A
PANTHER	PTHR11153	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11153
PSORT	swissprot:SFXN5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SFXN5_HUMAN
PSORT-B	swissprot:SFXN5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SFXN5_HUMAN
PSORT2	swissprot:SFXN5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SFXN5_HUMAN
Pfam	PF03820	http://pfam.xfam.org/family/PF03820
PharmGKB	PA38088	http://www.pharmgkb.org/do/serve?objId=PA38088&objCls=Gene
Phobius	swissprot:SFXN5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SFXN5_HUMAN
PhylomeDB	Q8TD22	http://phylomedb.org/?seqid=Q8TD22
ProteinModelPortal	Q8TD22	http://www.proteinmodelportal.org/query/uniprot/Q8TD22
PubMed	12039050	http://www.ncbi.nlm.nih.gov/pubmed/12039050
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
RefSeq	NP_653180	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_653180
STRING	9606.ENSP00000272433	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000272433&targetmode=cogs
TIGRFAMs	TIGR00798	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00798
UCSC	uc002siq	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002siq&org=rat
UniGene	Hs.368171	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.368171
UniProtKB	SFXN5_HUMAN	http://www.uniprot.org/uniprot/SFXN5_HUMAN
UniProtKB-AC	Q8TD22	http://www.uniprot.org/uniprot/Q8TD22
charge	swissprot:SFXN5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SFXN5_HUMAN
eggNOG	ENOG410YU8V	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YU8V
eggNOG	KOG3767	http://eggnogapi.embl.de/nog_data/html/tree/KOG3767
epestfind	swissprot:SFXN5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SFXN5_HUMAN
garnier	swissprot:SFXN5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SFXN5_HUMAN
helixturnhelix	swissprot:SFXN5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SFXN5_HUMAN
hmoment	swissprot:SFXN5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SFXN5_HUMAN
iep	swissprot:SFXN5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SFXN5_HUMAN
inforesidue	swissprot:SFXN5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SFXN5_HUMAN
neXtProt	NX_Q8TD22	http://www.nextprot.org/db/entry/NX_Q8TD22
octanol	swissprot:SFXN5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SFXN5_HUMAN
pepcoil	swissprot:SFXN5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SFXN5_HUMAN
pepdigest	swissprot:SFXN5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SFXN5_HUMAN
pepinfo	swissprot:SFXN5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SFXN5_HUMAN
pepnet	swissprot:SFXN5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SFXN5_HUMAN
pepstats	swissprot:SFXN5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SFXN5_HUMAN
pepwheel	swissprot:SFXN5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SFXN5_HUMAN
pepwindow	swissprot:SFXN5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SFXN5_HUMAN
sigcleave	swissprot:SFXN5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SFXN5_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	PK2L2_HUMAN	Event=Alternative splicing; Named isoforms=7; Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=Q9NZM6-1; Sequence=Displayed; Name=2; Synonyms=PKD2L2b; IsoId=Q9NZM6-2; Sequence=VSP_004732, VSP_004735; Name=3; Synonyms=PKD2L2a; IsoId=Q9NZM6-3; Sequence=VSP_004736, VSP_004737; Name=4; Synonyms=PKD2L2c; IsoId=Q9NZM6-4; Sequence=VSP_004733, VSP_004734; Name=5; IsoId=Q9NZM6-5; Sequence=VSP_035775; Note=No experimental confirmation available.; Name=6; IsoId=Q9NZM6-6; Sequence=VSP_045582; Note=No experimental confirmation available.; Name=7; IsoId=Q9NZM6-7; Sequence=VSP_045581; Note=No experimental confirmation available.; 
# AltName	PK2L2_HUMAN	Polycystin-2L2
# AltName	PK2L2_HUMAN	Polycystin-L2
# BioGrid	117970	4
# CCDS	CCDS43367	-. [Q9NZM6-5]
# CCDS	CCDS58971	-. [Q9NZM6-6]
# CCDS	CCDS58972	-. [Q9NZM6-7]
# CCDS	CCDS78062	-. [Q9NZM6-1]
# Ensembl	ENST00000290431	ENSP00000290431; ENSG00000078795. [Q9NZM6-5]
# Ensembl	ENST00000414094	ENSP00000388060; ENSG00000078795. [Q9NZM6-3]
# Ensembl	ENST00000502810	ENSP00000425513; ENSG00000078795. [Q9NZM6-7]
# Ensembl	ENST00000508638	ENSP00000423382; ENSG00000078795. [Q9NZM6-6]
# Ensembl	ENST00000508883	ENSP00000424725; ENSG00000078795. [Q9NZM6-1]
# ExpressionAtlas	Q9NZM6	baseline and differential
# FUNCTION	PK2L2_HUMAN	May function as a subunit of a cation channel and play a role in fertilization. 
# GO_component	GO:0016021	integral component of membrane; TAS:UniProtKB.
# GO_function	GO:0005262	calcium channel activity; IBA:GO_Central.
# GO_function	GO:0005509	calcium ion binding; IEA:InterPro.
# GO_process	GO:0050982	detection of mechanical stimulus; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q9NZM6	HS
# HGNC	HGNC:9012	PKD2L2
# InterPro	IPR003915	PKD_2
# InterPro	IPR013122	PKD1_2_channel
# KEGG_Brite	ko04040	Ion channels
# MIM	604669	gene
# Organism	PK2L2_HUMAN	Homo sapiens (Human)
# PRINTS	PR01433	POLYCYSTIN2
# Pfam	PF08016	PKD_channel
# Proteomes	UP000005640	Chromosome 5
# RecName	PK2L2_HUMAN	Polycystic kidney disease 2-like 2 protein
# RefSeq	NP_001245377	NM_001258448.1. [Q9NZM6-7]
# RefSeq	NP_001245378	NM_001258449.1. [Q9NZM6-6]
# RefSeq	NP_001287850	NM_001300921.1. [Q9NZM6-1]
# RefSeq	NP_055201	NM_014386.3. [Q9NZM6-5]
# RefSeq	XP_011541620	XM_011543318.2. [Q9NZM6-2]
# SEQUENCE CAUTION	Sequence=AAD46478.1; Type=Frameshift; Positions=595; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the polycystin family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	PK2L2_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TISSUE SPECIFICITY	According to PubMed:10602361, expressed only in testis. According to PubMed	10756092, expressed also in brain and kidney. Isoform 2 is found only in transformed lymphoblasts. Isoform 3 is found in all tissues tested. 
# UCSC	uc003lbw	human. [Q9NZM6-1]
# eggNOG	ENOG410XTGE	LUCA
# eggNOG	KOG3599	Eukaryota
BLAST	swissprot:PK2L2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:PK2L2_HUMAN
BioCyc	ZFISH:ENSG00000078795-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000078795-MONOMER
COXPRESdb	27039	http://coxpresdb.jp/data/gene/27039.shtml
CleanEx	HS_PKD2L2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_PKD2L2
DOI	10.1006/geno.2000.6131	http://dx.doi.org/10.1006/geno.2000.6131
DOI	10.1016/S0165-6147(00)01832-0	http://dx.doi.org/10.1016/S0165-6147(00)01832-0
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.ejhg.5200383	http://dx.doi.org/10.1038/sj.ejhg.5200383
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC106753	http://www.ebi.ac.uk/ena/data/view/AC106753
EMBL	AC106791	http://www.ebi.ac.uk/ena/data/view/AC106791
EMBL	AF118125	http://www.ebi.ac.uk/ena/data/view/AF118125
EMBL	AF182034	http://www.ebi.ac.uk/ena/data/view/AF182034
EMBL	AK301924	http://www.ebi.ac.uk/ena/data/view/AK301924
EMBL	BC044581	http://www.ebi.ac.uk/ena/data/view/BC044581
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
Ensembl	ENST00000290431	http://www.ensembl.org/id/ENST00000290431
Ensembl	ENST00000414094	http://www.ensembl.org/id/ENST00000414094
Ensembl	ENST00000502810	http://www.ensembl.org/id/ENST00000502810
Ensembl	ENST00000508638	http://www.ensembl.org/id/ENST00000508638
Ensembl	ENST00000508883	http://www.ensembl.org/id/ENST00000508883
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_process	GO:0050982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050982
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	PKD2L2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=PKD2L2
GeneID	27039	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27039
GeneTree	ENSGT00700000104221	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00700000104221
H-InvDB	HIX0024797	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0024797
HGNC	HGNC:9012	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:9012
HOGENOM	HOG000230858	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230858&db=HOGENOM6
HOVERGEN	HBG014945	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG014945&db=HOVERGEN
HPA	HPA041903	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA041903
HPA	HPA043634	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA043634
InParanoid	Q9NZM6	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NZM6
InterPro	IPR003915	http://www.ebi.ac.uk/interpro/entry/IPR003915
InterPro	IPR013122	http://www.ebi.ac.uk/interpro/entry/IPR013122
Jabion	27039	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=27039
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:27039	http://www.genome.jp/dbget-bin/www_bget?hsa:27039
KEGG_Orthology	KO:K04991	http://www.genome.jp/dbget-bin/www_bget?KO:K04991
MIM	604669	http://www.ncbi.nlm.nih.gov/omim/604669
OMA	IKEHANR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IKEHANR
OrthoDB	EOG091G034F	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G034F
PRINTS	PR01433	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01433
PSORT	swissprot:PK2L2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:PK2L2_HUMAN
PSORT-B	swissprot:PK2L2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:PK2L2_HUMAN
PSORT2	swissprot:PK2L2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:PK2L2_HUMAN
Pfam	PF08016	http://pfam.xfam.org/family/PF08016
PharmGKB	PA33345	http://www.pharmgkb.org/do/serve?objId=PA33345&objCls=Gene
Phobius	swissprot:PK2L2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:PK2L2_HUMAN
PhylomeDB	Q9NZM6	http://phylomedb.org/?seqid=Q9NZM6
ProteinModelPortal	Q9NZM6	http://www.proteinmodelportal.org/query/uniprot/Q9NZM6
PubMed	10602361	http://www.ncbi.nlm.nih.gov/pubmed/10602361
PubMed	10756092	http://www.ncbi.nlm.nih.gov/pubmed/10756092
PubMed	11698076	http://www.ncbi.nlm.nih.gov/pubmed/11698076
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
RefSeq	NP_001245377	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001245377
RefSeq	NP_001245378	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001245378
RefSeq	NP_001287850	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001287850
RefSeq	NP_055201	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055201
RefSeq	XP_011541620	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011541620
STRING	9606.ENSP00000290431	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000290431&targetmode=cogs
UCSC	uc003lbw	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003lbw&org=rat
UniGene	Hs.716884	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.716884
UniProtKB	PK2L2_HUMAN	http://www.uniprot.org/uniprot/PK2L2_HUMAN
UniProtKB-AC	Q9NZM6	http://www.uniprot.org/uniprot/Q9NZM6
charge	swissprot:PK2L2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:PK2L2_HUMAN
eggNOG	ENOG410XTGE	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XTGE
eggNOG	KOG3599	http://eggnogapi.embl.de/nog_data/html/tree/KOG3599
epestfind	swissprot:PK2L2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:PK2L2_HUMAN
garnier	swissprot:PK2L2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:PK2L2_HUMAN
helixturnhelix	swissprot:PK2L2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:PK2L2_HUMAN
hmoment	swissprot:PK2L2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:PK2L2_HUMAN
iep	swissprot:PK2L2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:PK2L2_HUMAN
inforesidue	swissprot:PK2L2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:PK2L2_HUMAN
neXtProt	NX_Q9NZM6	http://www.nextprot.org/db/entry/NX_Q9NZM6
octanol	swissprot:PK2L2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:PK2L2_HUMAN
pepcoil	swissprot:PK2L2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:PK2L2_HUMAN
pepdigest	swissprot:PK2L2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:PK2L2_HUMAN
pepinfo	swissprot:PK2L2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:PK2L2_HUMAN
pepnet	swissprot:PK2L2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:PK2L2_HUMAN
pepstats	swissprot:PK2L2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:PK2L2_HUMAN
pepwheel	swissprot:PK2L2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:PK2L2_HUMAN
pepwindow	swissprot:PK2L2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:PK2L2_HUMAN
sigcleave	swissprot:PK2L2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:PK2L2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TM40L_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q969M1-1; Sequence=Displayed; Name=2; IsoId=Q969M1-2; Sequence=VSP_054885; Note=No experimental confirmation available.; 
# AltName	TM40L_HUMAN	Protein TOMM40-like
# BioGrid	123906	6
# CCDS	CCDS1227	-. [Q969M1-1]
# CCDS	CCDS65700	-. [Q969M1-2]
# ChiTaRS	TOMM40L	human
# Ensembl	ENST00000367987	ENSP00000356966; ENSG00000158882. [Q969M1-1]
# Ensembl	ENST00000367988	ENSP00000356967; ENSG00000158882. [Q969M1-1]
# Ensembl	ENST00000545897	ENSP00000443233; ENSG00000158882. [Q969M1-2]
# FUNCTION	TM40L_HUMAN	Potential channel-forming protein implicated in import of protein precursors into mitochondria. {ECO 0000250}. 
# GO_component	GO:0005742	mitochondrial outer membrane translocase complex; IBA:GO_Central.
# GO_component	GO:0043234	protein complex; IDA:LIFEdb.
# GO_component	GO:0046930	pore complex; IEA:UniProtKB-KW.
# GO_function	GO:0015266	protein channel activity; IBA:GO_Central.
# GO_function	GO:0015288	porin activity; IEA:UniProtKB-KW.
# GO_process	GO:0006811	ion transport; IEA:UniProtKB-KW.
# GO_process	GO:0030150	protein import into mitochondrial matrix; IBA:GO_Central.
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.40.160.10	-; 1.
# Genevisible	Q969M1	HS
# HGNC	HGNC:25756	TOMM40L
# InterPro	IPR023614	Porin_dom
# InterPro	IPR027246	Porin_Euk/Tom40
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Pathway	ko05014	Amyotrophic lateral sclerosis (ALS)
# Organism	TM40L_HUMAN	Homo sapiens (Human)
# Pfam	PF01459	Porin_3
# Proteomes	UP000005640	Chromosome 1
# RecName	TM40L_HUMAN	Mitochondrial import receptor subunit TOM40B
# RefSeq	NP_001273302	NM_001286373.1. [Q969M1-2]
# RefSeq	NP_115550	NM_032174.5. [Q969M1-1]
# RefSeq	XP_006711635	XM_006711572.2. [Q969M1-1]
# RefSeq	XP_016857970	XM_017002481.1. [Q969M1-1]
# RefSeq	XP_016857971	XM_017002482.1. [Q969M1-2]
# SIMILARITY	Belongs to the Tom40 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	TM40L_HUMAN	Mitochondrion outer membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUBUNIT	Forms part of the preprotein translocase of the outer mitochondrial membrane (TOM complex) containing TOMM22, TOMM40, TOMM40L and TOMM70. Interacts with mitochondrial targeting sequences (By similarity). {ECO	0000250}. 
# UCSC	uc001fzd	human. [Q969M1-1]
# eggNOG	ENOG410XS2U	LUCA
# eggNOG	KOG3296	Eukaryota
BLAST	swissprot:TM40L_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TM40L_HUMAN
BioCyc	ZFISH:ENSG00000158882-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000158882-MONOMER
COXPRESdb	84134	http://coxpresdb.jp/data/gene/84134.shtml
CleanEx	HS_TOMM40L	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TOMM40L
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AK027704	http://www.ebi.ac.uk/ena/data/view/AK027704
EMBL	AK297848	http://www.ebi.ac.uk/ena/data/view/AK297848
EMBL	AL590714	http://www.ebi.ac.uk/ena/data/view/AL590714
EMBL	BC014946	http://www.ebi.ac.uk/ena/data/view/BC014946
EMBL	BX537951	http://www.ebi.ac.uk/ena/data/view/BX537951
EMBL	CH471121	http://www.ebi.ac.uk/ena/data/view/CH471121
EMBL	CH471121	http://www.ebi.ac.uk/ena/data/view/CH471121
EMBL	CH471121	http://www.ebi.ac.uk/ena/data/view/CH471121
Ensembl	ENST00000367987	http://www.ensembl.org/id/ENST00000367987
Ensembl	ENST00000367988	http://www.ensembl.org/id/ENST00000367988
Ensembl	ENST00000545897	http://www.ensembl.org/id/ENST00000545897
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005742	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005742
GO_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GO_component	GO:0046930	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046930
GO_function	GO:0015266	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015266
GO_function	GO:0015288	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015288
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0030150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030150
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.40.160.10	http://www.cathdb.info/version/latest/superfamily/2.40.160.10
GeneCards	TOMM40L	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TOMM40L
GeneID	84134	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84134
GeneTree	ENSGT00390000003308	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000003308
HGNC	HGNC:25756	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:25756
HOGENOM	HOG000007440	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007440&db=HOGENOM6
HOVERGEN	HBG054707	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054707&db=HOVERGEN
HPA	HPA051304	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA051304
InParanoid	Q969M1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q969M1
IntAct	Q969M1	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q969M1*
InterPro	IPR023614	http://www.ebi.ac.uk/interpro/entry/IPR023614
InterPro	IPR027246	http://www.ebi.ac.uk/interpro/entry/IPR027246
Jabion	84134	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=84134
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Gene	hsa:84134	http://www.genome.jp/dbget-bin/www_bget?hsa:84134
KEGG_Orthology	KO:K11518	http://www.genome.jp/dbget-bin/www_bget?KO:K11518
KEGG_Pathway	ko05014	http://www.genome.jp/kegg-bin/show_pathway?ko05014
MINT	MINT-4650450	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4650450
OMA	WGDRTIT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WGDRTIT
OrthoDB	EOG091G0MNA	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0MNA
PSORT	swissprot:TM40L_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TM40L_HUMAN
PSORT-B	swissprot:TM40L_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TM40L_HUMAN
PSORT2	swissprot:TM40L_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TM40L_HUMAN
Pfam	PF01459	http://pfam.xfam.org/family/PF01459
PharmGKB	PA142670714	http://www.pharmgkb.org/do/serve?objId=PA142670714&objCls=Gene
Phobius	swissprot:TM40L_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TM40L_HUMAN
PhylomeDB	Q969M1	http://phylomedb.org/?seqid=Q969M1
ProteinModelPortal	Q969M1	http://www.proteinmodelportal.org/query/uniprot/Q969M1
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
RefSeq	NP_001273302	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273302
RefSeq	NP_115550	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_115550
RefSeq	XP_006711635	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006711635
RefSeq	XP_016857970	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016857970
RefSeq	XP_016857971	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016857971
STRING	9606.ENSP00000356966	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000356966&targetmode=cogs
UCSC	uc001fzd	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001fzd&org=rat
UniGene	Hs.321653	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.321653
UniProtKB	TM40L_HUMAN	http://www.uniprot.org/uniprot/TM40L_HUMAN
UniProtKB-AC	Q969M1	http://www.uniprot.org/uniprot/Q969M1
charge	swissprot:TM40L_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TM40L_HUMAN
eggNOG	ENOG410XS2U	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS2U
eggNOG	KOG3296	http://eggnogapi.embl.de/nog_data/html/tree/KOG3296
epestfind	swissprot:TM40L_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TM40L_HUMAN
garnier	swissprot:TM40L_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TM40L_HUMAN
helixturnhelix	swissprot:TM40L_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TM40L_HUMAN
hmoment	swissprot:TM40L_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TM40L_HUMAN
iep	swissprot:TM40L_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TM40L_HUMAN
inforesidue	swissprot:TM40L_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TM40L_HUMAN
neXtProt	NX_Q969M1	http://www.nextprot.org/db/entry/NX_Q969M1
octanol	swissprot:TM40L_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TM40L_HUMAN
pepcoil	swissprot:TM40L_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TM40L_HUMAN
pepdigest	swissprot:TM40L_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TM40L_HUMAN
pepinfo	swissprot:TM40L_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TM40L_HUMAN
pepnet	swissprot:TM40L_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TM40L_HUMAN
pepstats	swissprot:TM40L_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TM40L_HUMAN
pepwheel	swissprot:TM40L_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TM40L_HUMAN
pepwindow	swissprot:TM40L_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TM40L_HUMAN
sigcleave	swissprot:TM40L_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TM40L_HUMAN
## Database	ID	URL or Descriptions
# AltName	ASNA_HUMAN	Transmembrane domain recognition complex 40 kDa ATPase subunit
# AltName	ASNA_HUMAN	hARSA-I
# AltName	ASNA_HUMAN	hASNA-I
# AltName	Arsenical pump-driving ATPase {ECO:0000255|HAMAP-Rule	MF_03112}
# AltName	Arsenite-stimulated ATPase {ECO:0000255|HAMAP-Rule	MF_03112}
# BIOPHYSICOCHEMICAL PROPERTIES	ASNA_HUMAN	Kinetic parameters  KM=0.22 mM for ATP {ECO 0000269|PubMed 9712828}; Vmax=16.6 nmol/min/mg enzyme for ATP {ECO 0000269|PubMed 9712828}; 
# BRENDA	3.6.3.16	2681
# BioGrid	106931	47
# ChiTaRS	ASNA1	human
# DrugBank	DB00171	Adenosine triphosphate
# Ensembl	ENST00000357332	ENSP00000349887; ENSG00000198356
# Ensembl	ENST00000591090	ENSP00000466379; ENSG00000198356
# ExpressionAtlas	O43681	baseline and differential
# FUNCTION	ASNA_HUMAN	ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting (By similarity). May be involved in insulin signaling. {ECO 0000255|HAMAP-Rule MF_03112, ECO 0000269|PubMed 17382883, ECO 0000269|PubMed 18477612}. 
# GO_component	GO:0005634	nucleus; IDA:HPA.
# GO_component	GO:0005730	nucleolus; IDA:HPA.
# GO_component	GO:0005737	cytoplasm; TAS:ProtInc.
# GO_component	GO:0005789	endoplasmic reticulum membrane; TAS:Reactome.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005215	transporter activity; TAS:ProtInc.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-HAMAP.
# GO_function	GO:0015105	arsenite transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0043492	ATPase activity, coupled to movement of substances; TAS:Reactome.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0036498	IRE1-mediated unfolded protein response; TAS:Reactome.
# GO_process	GO:0045048	protein insertion into ER membrane; IEA:UniProtKB-HAMAP.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005730	nucleolus
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# Gene3D	3.40.50.300	-; 2.
# Genevisible	O43681	HS
# HAMAP	MF_03112	Asna1_Get3
# HGNC	HGNC:752	ASNA1
# INTERACTION	ASNA_HUMAN	Q12797 ASPH; NbExp=3; IntAct=EBI-2515857, EBI-2967294; Q7L5D6 GET4; NbExp=3; IntAct=EBI-2515857, EBI-711823; Q96SL4 GPX7; NbExp=3; IntAct=EBI-2515857, EBI-749411; Q9Y5L2 HILPDA; NbExp=3; IntAct=EBI-2515857, EBI-8803836; 
# IntAct	O43681	17
# InterPro	IPR016300	ATPase_ArsA/GET3
# InterPro	IPR025723	Anion-transp_ATPase-like_dom
# InterPro	IPR027417	P-loop_NTPase
# InterPro	IPR027542	ATPase_ArsA/GET3_euk
# KEGG_Brite	ko01000	Enzymes
# KEGG_Brite	ko02000	 Transporters
# MIM	601913	gene
# Organism	ASNA_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10803	PTHR10803
# Pfam	PF02374	ArsA_ATPase
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-381038	XBP1(S) activates chaperone genes
# RecName	ATPase ASNA1 {ECO:0000255|HAMAP-Rule	MF_03112}
# RefSeq	NP_004308	NM_004317.3
# SEQUENCE CAUTION	Sequence=AAC50731.1; Type=Frameshift; Positions=19; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the arsA ATPase family. {ECO:0000255|HAMAP- Rule	MF_03112}. 
# SUBCELLULAR LOCATION	ASNA_HUMAN	Cytoplasm. Endoplasmic reticulum. Nucleus, nucleolus. 
# SUBUNIT	ASNA_HUMAN	Homodimer (By similarity). Component of a transmembrane domain recognition complex (TRC) (By similarity). Interacts with SERP1 and SEC61B (By similarity). Interacts with WRB. {ECO 0000255|HAMAP-Rule MF_03112, ECO 0000269|PubMed 17382883, ECO 0000269|PubMed 18477612, ECO 0000269|PubMed 21444755}. 
# SUPFAM	SSF52540	SSF52540
# TCDB	3.A.19.1	the tms recognition/insertion complex (trc) family
# TIGRFAMs	TIGR00345	GET3_arsA_TRC40
# TISSUE SPECIFICITY	Expressed in the epithelial cells of the liver, kidney, and stomach wall, in the adrenal medulla, in the islet cells of the pancreas, in the red pulp of the spleen, and in cardiac and skeletal muscle. {ECO:0000269|PubMed	9774623}. 
# UCSC	uc002muv	human
# WEB RESOURCE	ASNA_HUMAN	Name=NIEHS-SNPs; URL="http //egp.gs.washington.edu/data/asna1/";
# eggNOG	COG0003	LUCA
# eggNOG	KOG2825	Eukaryota
BLAST	swissprot:ASNA_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ASNA_HUMAN
BioCyc	ZFISH:HS02764-MONOMER	http://biocyc.org/getid?id=ZFISH:HS02764-MONOMER
COG	COG0003	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0003
COXPRESdb	439	http://coxpresdb.jp/data/gene/439.shtml
CleanEx	HS_ARSA	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ARSA
CleanEx	HS_ASNA1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ASNA1
DOI	10.1002/(SICI)1097-4644(19981001)71:1<1::AID-JCB1>3.3.CO	http://dx.doi.org/10.1002/(SICI)1097-4644(19981001)71:1<1::AID-JCB1>3.3.CO
DOI	10.1006/geno.1996.0494	http://dx.doi.org/10.1006/geno.1996.0494
DOI	10.1016/j.cell.2007.01.036	http://dx.doi.org/10.1016/j.cell.2007.01.036
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.273.35.22173	http://dx.doi.org/10.1074/jbc.273.35.22173
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1177/002215549804601104	http://dx.doi.org/10.1177/002215549804601104
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1242/jcs.020321	http://dx.doi.org/10.1242/jcs.020321
DOI	10.1242/jcs.084277	http://dx.doi.org/10.1242/jcs.084277
DrugBank	DB00171	http://www.drugbank.ca/drugs/DB00171
EC_number	EC:3.6.-.- {ECO:0000255|HAMAP-Rule:MF_03112}	http://www.genome.jp/dbget-bin/www_bget?EC:3.6.-.- {ECO:0000255|HAMAP-Rule:MF_03112}
EMBL	AC018761	http://www.ebi.ac.uk/ena/data/view/AC018761
EMBL	AF047469	http://www.ebi.ac.uk/ena/data/view/AF047469
EMBL	AK223363	http://www.ebi.ac.uk/ena/data/view/AK223363
EMBL	AK291855	http://www.ebi.ac.uk/ena/data/view/AK291855
EMBL	AY304483	http://www.ebi.ac.uk/ena/data/view/AY304483
EMBL	BC002651	http://www.ebi.ac.uk/ena/data/view/BC002651
EMBL	CH471106	http://www.ebi.ac.uk/ena/data/view/CH471106
EMBL	U60276	http://www.ebi.ac.uk/ena/data/view/U60276
ENZYME	3.6.-.- {ECO:0000255|HAMAP-Rule:MF_03112}	http://enzyme.expasy.org/EC/3.6.-.- {ECO:0000255|HAMAP-Rule:MF_03112}
Ensembl	ENST00000357332	http://www.ensembl.org/id/ENST00000357332
Ensembl	ENST00000591090	http://www.ensembl.org/id/ENST00000591090
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005730
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0015105	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015105
GO_function	GO:0043492	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043492
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0036498	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036498
GO_process	GO:0045048	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045048
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005730
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ASNA1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ASNA1
GeneID	439	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=439
GeneTree	ENSGT00390000003817	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000003817
HAMAP	MF_03112	http://hamap.expasy.org/unirule/MF_03112
HGNC	HGNC:752	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:752
HOGENOM	HOG000197637	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000197637&db=HOGENOM6
HPA	HPA045951	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA045951
HPA	HPA048087	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA048087
InParanoid	O43681	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O43681
IntAct	O43681	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O43681*
IntEnz	3.6.-.- {ECO:0000255|HAMAP-Rule:MF_03112}	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.-.- {ECO:0000255|HAMAP-Rule:MF_03112}
InterPro	IPR016300	http://www.ebi.ac.uk/interpro/entry/IPR016300
InterPro	IPR025723	http://www.ebi.ac.uk/interpro/entry/IPR025723
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
InterPro	IPR027542	http://www.ebi.ac.uk/interpro/entry/IPR027542
Jabion	439	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=439
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:439	http://www.genome.jp/dbget-bin/www_bget?hsa:439
KEGG_Orthology	KO:K01551	http://www.genome.jp/dbget-bin/www_bget?KO:K01551
MIM	601913	http://www.ncbi.nlm.nih.gov/omim/601913
MINT	MINT-4656878	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4656878
OMA	YEIDTHN	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YEIDTHN
OrthoDB	EOG091G0CAR	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0CAR
PANTHER	PTHR10803	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10803
PSORT	swissprot:ASNA_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ASNA_HUMAN
PSORT-B	swissprot:ASNA_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ASNA_HUMAN
PSORT2	swissprot:ASNA_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ASNA_HUMAN
Pfam	PF02374	http://pfam.xfam.org/family/PF02374
PharmGKB	PA25051	http://www.pharmgkb.org/do/serve?objId=PA25051&objCls=Gene
Phobius	swissprot:ASNA_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ASNA_HUMAN
PhylomeDB	O43681	http://phylomedb.org/?seqid=O43681
ProteinModelPortal	O43681	http://www.proteinmodelportal.org/query/uniprot/O43681
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17382883	http://www.ncbi.nlm.nih.gov/pubmed/17382883
PubMed	18477612	http://www.ncbi.nlm.nih.gov/pubmed/18477612
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21444755	http://www.ncbi.nlm.nih.gov/pubmed/21444755
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	8884272	http://www.ncbi.nlm.nih.gov/pubmed/8884272
PubMed	9712828	http://www.ncbi.nlm.nih.gov/pubmed/9712828
PubMed	9736449	http://www.ncbi.nlm.nih.gov/pubmed/9736449
PubMed	9774623	http://www.ncbi.nlm.nih.gov/pubmed/9774623
Reactome	R-HSA-381038	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-381038
RefSeq	NP_004308	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004308
SMR	O43681	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O43681
STRING	9606.ENSP00000349887	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000349887&targetmode=cogs
STRING	COG0003	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0003&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TCDB	3.A.19.1	http://www.tcdb.org/search/result.php?tc=3.A.19.1
TIGRFAMs	TIGR00345	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00345
UCSC	uc002muv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002muv&org=rat
UniGene	Hs.465985	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.465985
UniProtKB	ASNA_HUMAN	http://www.uniprot.org/uniprot/ASNA_HUMAN
UniProtKB-AC	O43681	http://www.uniprot.org/uniprot/O43681
charge	swissprot:ASNA_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ASNA_HUMAN
eggNOG	COG0003	http://eggnogapi.embl.de/nog_data/html/tree/COG0003
eggNOG	KOG2825	http://eggnogapi.embl.de/nog_data/html/tree/KOG2825
epestfind	swissprot:ASNA_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ASNA_HUMAN
garnier	swissprot:ASNA_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ASNA_HUMAN
helixturnhelix	swissprot:ASNA_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ASNA_HUMAN
hmoment	swissprot:ASNA_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ASNA_HUMAN
iep	swissprot:ASNA_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ASNA_HUMAN
inforesidue	swissprot:ASNA_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ASNA_HUMAN
neXtProt	NX_O43681	http://www.nextprot.org/db/entry/NX_O43681
octanol	swissprot:ASNA_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ASNA_HUMAN
pepcoil	swissprot:ASNA_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ASNA_HUMAN
pepdigest	swissprot:ASNA_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ASNA_HUMAN
pepinfo	swissprot:ASNA_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ASNA_HUMAN
pepnet	swissprot:ASNA_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ASNA_HUMAN
pepstats	swissprot:ASNA_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ASNA_HUMAN
pepwheel	swissprot:ASNA_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ASNA_HUMAN
pepwindow	swissprot:ASNA_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ASNA_HUMAN
sigcleave	swissprot:ASNA_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ASNA_HUMAN
## Database	ID	URL or Descriptions
# AltName	AQP2_HUMAN	ADH water channel
# AltName	AQP2_HUMAN	Aquaporin-CD
# AltName	AQP2_HUMAN	Collecting duct water channel protein
# AltName	AQP2_HUMAN	WCH-CD
# AltName	AQP2_HUMAN	Water channel protein for renal collecting duct
# CDD	cd00333	MIP
# DISEASE	AQP2_HUMAN	Diabetes insipidus, nephrogenic, autosomal (ANDI) [MIM 125800]  A disorder caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. Characterized by excessive water drinking (polydipsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia. Inheritance can be autosomal dominant or recessive. {ECO 0000269|PubMed 12050236, ECO 0000269|PubMed 12191971, ECO 0000269|PubMed 15509592, ECO 0000269|PubMed 16120822, ECO 0000269|PubMed 16361827, ECO 0000269|PubMed 16845277, ECO 0000269|PubMed 19585583, ECO 0000269|PubMed 24944815, ECO 0000269|PubMed 7524315, ECO 0000269|PubMed 8882880, ECO 0000269|PubMed 9048343, ECO 0000269|PubMed 9302264, ECO 0000269|PubMed 9402087, ECO 0000269|PubMed 9550615, ECO 0000269|PubMed 9649557, ECO 0000269|PubMed 9745427}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	AQP2_HUMAN	Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). 
# Ensembl	ENST00000199280	ENSP00000199280; ENSG00000167580
# ExpressionAtlas	P41181	baseline and differential
# FUNCTION	AQP2_HUMAN	Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. 
# GO_component	GO:0005794	Golgi apparatus; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016020	membrane; IDA:MGI.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_component	GO:0030658	transport vesicle membrane; TAS:Reactome.
# GO_component	GO:0055037	recycling endosome; IEA:Ensembl.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005372	water transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015168	glycerol transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015250	water channel activity; EXP:Reactome.
# GO_function	GO:0015254	glycerol channel activity; IBA:GO_Central.
# GO_process	GO:0003091	renal water homeostasis; TAS:Reactome.
# GO_process	GO:0003097	renal water transport; IEA:Ensembl.
# GO_process	GO:0006833	water transport; IDA:UniProtKB.
# GO_process	GO:0007588	excretion; TAS:ProtInc.
# GO_process	GO:0009992	cellular water homeostasis; IBA:GO_Central.
# GO_process	GO:0015793	glycerol transport; IDA:UniProtKB.
# GO_process	GO:0034220	ion transmembrane transport; IBA:GO_Central.
# GO_process	GO:0042631	cellular response to water deprivation; IEA:Ensembl.
# GO_process	GO:0071280	cellular response to copper ion; IDA:UniProtKB.
# GO_process	GO:0071288	cellular response to mercury ion; IDA:UniProtKB.
# GO_process	GO:0072205	metanephric collecting duct development; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.1080.10	-; 1.
# Genevisible	P41181	HS
# HGNC	HGNC:634	AQP2
# InterPro	IPR000425	MIP
# InterPro	IPR022357	MIP_CS
# InterPro	IPR023271	Aquaporin-like
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00252	[Endocrine disease; Kidney disease] Congenital nephrogenic diabetes insipidus (NDI)
# KEGG_Pathway	ko04962	Vasopressin-regulated water reabsorption
# MIM	107777	gene
# MIM	125800	phenotype
# Organism	AQP2_HUMAN	Homo sapiens (Human)
# Orphanet	223	Nephrogenic diabetes insipidus
# PANTHER	PTHR19139	PTHR19139
# PDB	4NEF	X-ray; 2.75 A; A/B/C/D=3-241
# PDB	4OJ2	X-ray; 3.05 A; X=1-271
# PIR	A53442	A53442
# PIR	I64818	I64818
# PRINTS	PR00783	MINTRINSICP
# PROSITE	PS00221	MIP
# PTM	AQP2_HUMAN	Ser-256 phosphorylation is necessary and sufficient for expression at the apical membrane. Endocytosis is not phosphorylation-dependent. {ECO 0000269|PubMed 12194985}. 
# Pfam	PF00230	MIP
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-432040	Vasopressin regulates renal water homeostasis via Aquaporins
# Reactome	R-HSA-432047	Passive transport by Aquaporins
# RecName	AQP2_HUMAN	Aquaporin-2
# RefSeq	NP_000477	NM_000486.5
# SIMILARITY	Belongs to the MIP/aquaporin (TC 1.A.8) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	AQP2_HUMAN	Apical cell membrane {ECO 0000269|PubMed 12194985}; Multi-pass membrane protein {ECO 0000269|PubMed 12194985}. Basolateral cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Cytoplasmic vesicle membrane {ECO 0000269|PubMed 12194985}; Multi- pass membrane protein {ECO 0000269|PubMed 12194985}. Golgi apparatus, trans-Golgi network membrane {ECO 0000269|PubMed 12194985}; Multi-pass membrane protein {ECO 0000269|PubMed 12194985}. Note=Shuttles from vesicles to the apical membrane. Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane. PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated. 
# SUPFAM	SSF81338	SSF81338
# TCDB	1.A.8.8	the major intrinsic protein (mip) family
# TIGRFAMs	TIGR00861	MIP
# TISSUE SPECIFICITY	AQP2_HUMAN	Expressed in renal collecting tubules. 
# UCSC	uc001rvn	human
# eggNOG	COG0580	LUCA
# eggNOG	KOG0223	Eukaryota
BLAST	swissprot:AQP2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AQP2_HUMAN
BioCyc	ZFISH:ENSG00000167580-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000167580-MONOMER
COXPRESdb	359	http://coxpresdb.jp/data/gene/359.shtml
CleanEx	HS_AQP2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AQP2
DOI	10.1002/humu.21068	http://dx.doi.org/10.1002/humu.21068
DOI	10.1002/humu.21082	http://dx.doi.org/10.1002/humu.21082
DOI	10.1007/s004390050264	http://dx.doi.org/10.1007/s004390050264
DOI	10.1074/jbc.M207525200	http://dx.doi.org/10.1074/jbc.M207525200
DOI	10.1093/hmg/11.7.779	http://dx.doi.org/10.1093/hmg/11.7.779
DOI	10.1093/hmg/6.11.1865	http://dx.doi.org/10.1093/hmg/6.11.1865
DOI	10.1093/hmg/ddh339	http://dx.doi.org/10.1093/hmg/ddh339
DOI	10.1097/01.ASN.0000027355.41663.14	http://dx.doi.org/10.1097/01.ASN.0000027355.41663.14
DOI	10.1097/01.gim.0000223554.46981.7a	http://dx.doi.org/10.1097/01.gim.0000223554.46981.7a
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.8140421	http://dx.doi.org/10.1126/science.8140421
DOI	10.1172/JCI117079	http://dx.doi.org/10.1172/JCI117079
DOI	10.1172/JCI2605	http://dx.doi.org/10.1172/JCI2605
DOI	10.1210/jc.83.9.3205	http://dx.doi.org/10.1210/jc.83.9.3205
DOI	10.1210/jc.87.6.2694	http://dx.doi.org/10.1210/jc.87.6.2694
DOI	10.1681/ASN.2005010104	http://dx.doi.org/10.1681/ASN.2005010104
DOI	10.3346/jkms.2005.20.6.1076	http://dx.doi.org/10.3346/jkms.2005.20.6.1076
DOI	10.3892/br.2014.283	http://dx.doi.org/10.3892/br.2014.283
EMBL	AF147092	http://www.ebi.ac.uk/ena/data/view/AF147092
EMBL	AF147093	http://www.ebi.ac.uk/ena/data/view/AF147093
EMBL	BC042496	http://www.ebi.ac.uk/ena/data/view/BC042496
EMBL	D31846	http://www.ebi.ac.uk/ena/data/view/D31846
EMBL	S73196	http://www.ebi.ac.uk/ena/data/view/S73196
EMBL	S73197	http://www.ebi.ac.uk/ena/data/view/S73197
EMBL	Z29491	http://www.ebi.ac.uk/ena/data/view/Z29491
Ensembl	ENST00000199280	http://www.ensembl.org/id/ENST00000199280
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0030658	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030658
GO_component	GO:0055037	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055037
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005372	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005372
GO_function	GO:0015168	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015168
GO_function	GO:0015250	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015250
GO_function	GO:0015254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015254
GO_process	GO:0003091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003091
GO_process	GO:0003097	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003097
GO_process	GO:0006833	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006833
GO_process	GO:0007588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007588
GO_process	GO:0009992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009992
GO_process	GO:0015793	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015793
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0042631	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042631
GO_process	GO:0071280	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071280
GO_process	GO:0071288	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071288
GO_process	GO:0072205	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072205
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.1080.10	http://www.cathdb.info/version/latest/superfamily/1.20.1080.10
GeneCards	AQP2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=AQP2
GeneID	359	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=359
GeneTree	ENSGT00760000119223	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119223
HGNC	HGNC:634	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:634
HOGENOM	HOG000288286	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000288286&db=HOGENOM6
HOVERGEN	HBG000312	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000312&db=HOVERGEN
HPA	HPA046834	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA046834
InParanoid	P41181	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P41181
InterPro	IPR000425	http://www.ebi.ac.uk/interpro/entry/IPR000425
InterPro	IPR022357	http://www.ebi.ac.uk/interpro/entry/IPR022357
InterPro	IPR023271	http://www.ebi.ac.uk/interpro/entry/IPR023271
Jabion	359	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=359
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00252	http://www.genome.jp/dbget-bin/www_bget?H00252
KEGG_Gene	hsa:359	http://www.genome.jp/dbget-bin/www_bget?hsa:359
KEGG_Orthology	KO:K09865	http://www.genome.jp/dbget-bin/www_bget?KO:K09865
KEGG_Pathway	ko04962	http://www.genome.jp/kegg-bin/show_pathway?ko04962
MIM	107777	http://www.ncbi.nlm.nih.gov/omim/107777
MIM	125800	http://www.ncbi.nlm.nih.gov/omim/125800
OMA	DHSPADY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DHSPADY
Orphanet	223	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=223
OrthoDB	EOG091G166T	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G166T
PANTHER	PTHR19139	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19139
PDB	4NEF	http://www.ebi.ac.uk/pdbe-srv/view/entry/4NEF
PDB	4OJ2	http://www.ebi.ac.uk/pdbe-srv/view/entry/4OJ2
PDBsum	4NEF	http://www.ebi.ac.uk/pdbsum/4NEF
PDBsum	4OJ2	http://www.ebi.ac.uk/pdbsum/4OJ2
PRINTS	PR00783	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00783
PROSITE	PS00221	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00221
PSORT	swissprot:AQP2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AQP2_HUMAN
PSORT-B	swissprot:AQP2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AQP2_HUMAN
PSORT2	swissprot:AQP2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AQP2_HUMAN
Pfam	PF00230	http://pfam.xfam.org/family/PF00230
PharmGKB	PA24920	http://www.pharmgkb.org/do/serve?objId=PA24920&objCls=Gene
Phobius	swissprot:AQP2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AQP2_HUMAN
PhylomeDB	P41181	http://phylomedb.org/?seqid=P41181
ProteinModelPortal	P41181	http://www.proteinmodelportal.org/query/uniprot/P41181
PubMed	11929850	http://www.ncbi.nlm.nih.gov/pubmed/11929850
PubMed	12050236	http://www.ncbi.nlm.nih.gov/pubmed/12050236
PubMed	12191971	http://www.ncbi.nlm.nih.gov/pubmed/12191971
PubMed	12194985	http://www.ncbi.nlm.nih.gov/pubmed/12194985
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15509592	http://www.ncbi.nlm.nih.gov/pubmed/15509592
PubMed	16120822	http://www.ncbi.nlm.nih.gov/pubmed/16120822
PubMed	16361827	http://www.ncbi.nlm.nih.gov/pubmed/16361827
PubMed	16845277	http://www.ncbi.nlm.nih.gov/pubmed/16845277
PubMed	19585583	http://www.ncbi.nlm.nih.gov/pubmed/19585583
PubMed	19701945	http://www.ncbi.nlm.nih.gov/pubmed/19701945
PubMed	24944815	http://www.ncbi.nlm.nih.gov/pubmed/24944815
PubMed	7510718	http://www.ncbi.nlm.nih.gov/pubmed/7510718
PubMed	7522228	http://www.ncbi.nlm.nih.gov/pubmed/7522228
PubMed	7524315	http://www.ncbi.nlm.nih.gov/pubmed/7524315
PubMed	8140421	http://www.ncbi.nlm.nih.gov/pubmed/8140421
PubMed	8882880	http://www.ncbi.nlm.nih.gov/pubmed/8882880
PubMed	9048343	http://www.ncbi.nlm.nih.gov/pubmed/9048343
PubMed	9302264	http://www.ncbi.nlm.nih.gov/pubmed/9302264
PubMed	9402087	http://www.ncbi.nlm.nih.gov/pubmed/9402087
PubMed	9550615	http://www.ncbi.nlm.nih.gov/pubmed/9550615
PubMed	9649557	http://www.ncbi.nlm.nih.gov/pubmed/9649557
PubMed	9745427	http://www.ncbi.nlm.nih.gov/pubmed/9745427
Reactome	R-HSA-432040	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432040
Reactome	R-HSA-432047	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432047
RefSeq	NP_000477	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000477
SMR	P41181	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P41181
STRING	9606.ENSP00000199280	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000199280&targetmode=cogs
SUPFAM	SSF81338	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81338
TCDB	1.A.8.8	http://www.tcdb.org/search/result.php?tc=1.A.8.8
TIGRFAMs	TIGR00861	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00861
UCSC	uc001rvn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001rvn&org=rat
UniGene	Hs.130730	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.130730
UniProtKB	AQP2_HUMAN	http://www.uniprot.org/uniprot/AQP2_HUMAN
UniProtKB-AC	P41181	http://www.uniprot.org/uniprot/P41181
charge	swissprot:AQP2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AQP2_HUMAN
eggNOG	COG0580	http://eggnogapi.embl.de/nog_data/html/tree/COG0580
eggNOG	KOG0223	http://eggnogapi.embl.de/nog_data/html/tree/KOG0223
epestfind	swissprot:AQP2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AQP2_HUMAN
garnier	swissprot:AQP2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AQP2_HUMAN
helixturnhelix	swissprot:AQP2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AQP2_HUMAN
hmoment	swissprot:AQP2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AQP2_HUMAN
iep	swissprot:AQP2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AQP2_HUMAN
inforesidue	swissprot:AQP2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AQP2_HUMAN
neXtProt	NX_P41181	http://www.nextprot.org/db/entry/NX_P41181
octanol	swissprot:AQP2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AQP2_HUMAN
pepcoil	swissprot:AQP2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AQP2_HUMAN
pepdigest	swissprot:AQP2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AQP2_HUMAN
pepinfo	swissprot:AQP2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AQP2_HUMAN
pepnet	swissprot:AQP2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AQP2_HUMAN
pepstats	swissprot:AQP2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AQP2_HUMAN
pepwheel	swissprot:AQP2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AQP2_HUMAN
pepwindow	swissprot:AQP2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AQP2_HUMAN
sigcleave	swissprot:AQP2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AQP2_HUMAN
## Database	ID	URL or Descriptions
# CAUTION	Could be the product of a pseudogene. {ECO	0000305}.
# Ensembl	ENST00000374097	ENSP00000363210; ENSG00000204152
# Ensembl	ENST00000374098	ENSP00000363211; ENSG00000204152
# ExpressionAtlas	Q5SRD1	baseline and differential
# FUNCTION	TI23B_HUMAN	May participate in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane. the PAM complex (By similarity). {ECO 0000250}. 
# GO_component	GO:0005744	mitochondrial inner membrane presequence translocase complex; IBA:GO_Central.
# GO_component	GO:0031305	integral component of mitochondrial inner membrane; IBA:GO_Central.
# GO_function	GO:0015266	protein channel activity; IBA:GO_Central.
# GO_function	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity; IEA:InterPro.
# GO_process	GO:0030150	protein import into mitochondrial matrix; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q5SRD1	HS
# HGNC	HGNC:23581	TIMM23B
# InterPro	IPR003397	Tim17/Tim22/Tim23/PMP24
# InterPro	IPR005681	Tim23
# Organism	TI23B_HUMAN	Homo sapiens (Human)
# Pfam	PF02466	Tim17
# Proteomes	UP000005640	Chromosome 10
# RecName	TI23B_HUMAN	Putative mitochondrial import inner membrane translocase subunit Tim23B
# SIMILARITY	Belongs to the Tim17/Tim22/Tim23 family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	TI23B_HUMAN	Mitochondrion inner membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# TIGRFAMs	TIGR00983	3a0801s02tim23
# UCSC	uc031wgt	human
# eggNOG	COG5596	LUCA
# eggNOG	KOG3324	Eukaryota
BLAST	swissprot:TI23B_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TI23B_HUMAN
BioCyc	ZFISH:G66-33614-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33614-MONOMER
CleanEx	HS_TIMM23B	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TIMM23B
DOI	10.1038/nature02462	http://dx.doi.org/10.1038/nature02462
EMBL	AL672187	http://www.ebi.ac.uk/ena/data/view/AL672187
EMBL	AL672187	http://www.ebi.ac.uk/ena/data/view/AL672187
Ensembl	ENST00000374097	http://www.ensembl.org/id/ENST00000374097
Ensembl	ENST00000374098	http://www.ensembl.org/id/ENST00000374098
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005744	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005744
GO_component	GO:0031305	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031305
GO_function	GO:0015266	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015266
GO_function	GO:0015450	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015450
GO_process	GO:0030150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030150
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	TIMM23B	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TIMM23B
HGNC	HGNC:23581	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:23581
HOGENOM	HOG000208442	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000208442&db=HOGENOM6
HOVERGEN	HBG057526	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG057526&db=HOVERGEN
InParanoid	Q5SRD1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q5SRD1
IntAct	Q5SRD1	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q5SRD1*
InterPro	IPR003397	http://www.ebi.ac.uk/interpro/entry/IPR003397
InterPro	IPR005681	http://www.ebi.ac.uk/interpro/entry/IPR005681
OrthoDB	EOG091G0NP6	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0NP6
PSORT	swissprot:TI23B_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TI23B_HUMAN
PSORT-B	swissprot:TI23B_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TI23B_HUMAN
PSORT2	swissprot:TI23B_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TI23B_HUMAN
Pfam	PF02466	http://pfam.xfam.org/family/PF02466
Phobius	swissprot:TI23B_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TI23B_HUMAN
PhylomeDB	Q5SRD1	http://phylomedb.org/?seqid=Q5SRD1
ProteinModelPortal	Q5SRD1	http://www.proteinmodelportal.org/query/uniprot/Q5SRD1
PubMed	15164054	http://www.ncbi.nlm.nih.gov/pubmed/15164054
STRING	9606.ENSP00000363211	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000363211&targetmode=cogs
TIGRFAMs	TIGR00983	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00983
UCSC	uc031wgt	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc031wgt&org=rat
UniGene	Hs.499594	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.499594
UniGene	Hs.524308	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.524308
UniProtKB	TI23B_HUMAN	http://www.uniprot.org/uniprot/TI23B_HUMAN
UniProtKB-AC	Q5SRD1	http://www.uniprot.org/uniprot/Q5SRD1
charge	swissprot:TI23B_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TI23B_HUMAN
eggNOG	COG5596	http://eggnogapi.embl.de/nog_data/html/tree/COG5596
eggNOG	KOG3324	http://eggnogapi.embl.de/nog_data/html/tree/KOG3324
epestfind	swissprot:TI23B_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TI23B_HUMAN
garnier	swissprot:TI23B_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TI23B_HUMAN
helixturnhelix	swissprot:TI23B_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TI23B_HUMAN
hmoment	swissprot:TI23B_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TI23B_HUMAN
iep	swissprot:TI23B_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TI23B_HUMAN
inforesidue	swissprot:TI23B_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TI23B_HUMAN
neXtProt	NX_Q5SRD1	http://www.nextprot.org/db/entry/NX_Q5SRD1
octanol	swissprot:TI23B_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TI23B_HUMAN
pepcoil	swissprot:TI23B_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TI23B_HUMAN
pepdigest	swissprot:TI23B_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TI23B_HUMAN
pepinfo	swissprot:TI23B_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TI23B_HUMAN
pepnet	swissprot:TI23B_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TI23B_HUMAN
pepstats	swissprot:TI23B_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TI23B_HUMAN
pepwheel	swissprot:TI23B_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TI23B_HUMAN
pepwindow	swissprot:TI23B_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TI23B_HUMAN
sigcleave	swissprot:TI23B_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TI23B_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNS1_HUMAN	Delayed-rectifier K(+) channel alpha subunit 1
# AltName	KCNS1_HUMAN	Voltage-gated potassium channel subunit Kv9.1
# DOMAIN	KCNS1_HUMAN	The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. {ECO 0000250|UniProtKB P63142}. 
# Ensembl	ENST00000306117	ENSP00000307694; ENSG00000124134
# Ensembl	ENST00000537075	ENSP00000445595; ENSG00000124134
# ExpressionAtlas	Q96KK3	baseline and differential
# FUNCTION	KCNS1_HUMAN	Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage- gated potassium channel activation and deactivation rates of KCNB1 and KCNB2 (PubMed 10484328). {ECO 0000269|PubMed 10484328}. 
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IDA:UniProtKB.
# GO_component	GO:0048471	perinuclear region of cytoplasm; ISS:UniProtKB.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; IDA:UniProtKB.
# GO_function	GO:0015459	potassium channel regulator activity; IDA:UniProtKB.
# GO_process	GO:0006813	potassium ion transport; TAS:UniProtKB.
# GO_process	GO:0051260	protein homooligomerization; IEA:InterPro.
# GO_process	GO:1902259	regulation of delayed rectifier potassium channel activity; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.20.120.350	-; 1.
# Genevisible	Q96KK3	HS
# HGNC	HGNC:6300	KCNS1
# InterPro	IPR000210	BTB/POZ_dom
# InterPro	IPR003131	T1-type_BTB
# InterPro	IPR003968	K_chnl_volt-dep_Kv
# InterPro	IPR003971	K_chnl_volt-dep_Kv9
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR011333	SKP1/BTB/POZ
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko04040	Ion channels
# MIM	602905	gene
# Organism	KCNS1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11537	PTHR11537
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01491	KVCHANNEL
# PRINTS	PR01494	KV9CHANNEL
# Pfam	PF00520	Ion_trans
# Pfam	PF02214	BTB_2
# Proteomes	UP000005640	Chromosome 20
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# RecName	KCNS1_HUMAN	Potassium voltage-gated channel subfamily S member 1
# RefSeq	NP_001309728	NM_001322799.1
# RefSeq	NP_002242	NM_002251.4
# SIMILARITY	Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily. {ECO	0000305}.
# SMART	SM00225	BTB
# SUBCELLULAR LOCATION	KCNS1_HUMAN	Cell membrane {ECO 0000269|PubMed 10484328}; Multi-pass membrane protein {ECO 0000305}. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 or KCNB2 (PubMed 10484328). {ECO 0000269|PubMed 10484328}. 
# SUBUNIT	KCNS1_HUMAN	Heterotetramer with KCNB1 (PubMed 10484328). Heterotetramer with KCNB2 (By similarity). Does not form homomultimers (PubMed 10484328). {ECO 0000250|UniProtKB O35173, ECO 0000269|PubMed 10484328}. 
# SUPFAM	SSF54695	SSF54695
# TCDB	1.A.1.2	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	Detected in all tissues tested with the exception of skeletal muscle. Highly expressed in adult and fetal brain, fetal kidney and lung, and adult prostate and testis (PubMed:10484328). {ECO	0000269|PubMed:10484328}. 
# UCSC	uc002xnc	human
# eggNOG	COG1226	LUCA
# eggNOG	KOG3713	Eukaryota
BLAST	swissprot:KCNS1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNS1_HUMAN
BioCyc	ZFISH:ENSG00000124134-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000124134-MONOMER
COXPRESdb	3787	http://coxpresdb.jp/data/gene/3787.shtml
CleanEx	HS_KCNS1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNS1
DOI	10.1038/414865a	http://dx.doi.org/10.1038/414865a
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF043473	http://www.ebi.ac.uk/ena/data/view/AF043473
EMBL	BC075033	http://www.ebi.ac.uk/ena/data/view/BC075033
EMBL	BC075034	http://www.ebi.ac.uk/ena/data/view/BC075034
EMBL	BC132959	http://www.ebi.ac.uk/ena/data/view/BC132959
EMBL	BC144234	http://www.ebi.ac.uk/ena/data/view/BC144234
EMBL	Z93016	http://www.ebi.ac.uk/ena/data/view/Z93016
Ensembl	ENST00000306117	http://www.ensembl.org/id/ENST00000306117
Ensembl	ENST00000537075	http://www.ensembl.org/id/ENST00000537075
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_function	GO:0015459	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015459
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:1902259	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902259
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	KCNS1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNS1
GeneID	3787	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3787
GeneTree	ENSGT00760000118981	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118981
HGNC	HGNC:6300	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6300
HOGENOM	HOG000231016	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231016&db=HOGENOM6
HOVERGEN	HBG052230	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052230&db=HOVERGEN
InParanoid	Q96KK3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96KK3
InterPro	IPR000210	http://www.ebi.ac.uk/interpro/entry/IPR000210
InterPro	IPR003131	http://www.ebi.ac.uk/interpro/entry/IPR003131
InterPro	IPR003968	http://www.ebi.ac.uk/interpro/entry/IPR003968
InterPro	IPR003971	http://www.ebi.ac.uk/interpro/entry/IPR003971
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR011333	http://www.ebi.ac.uk/interpro/entry/IPR011333
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	3787	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3787
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3787	http://www.genome.jp/dbget-bin/www_bget?hsa:3787
KEGG_Orthology	KO:K04931	http://www.genome.jp/dbget-bin/www_bget?KO:K04931
MIM	602905	http://www.ncbi.nlm.nih.gov/omim/602905
OMA	WLTLENP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WLTLENP
OrthoDB	EOG091G0FP3	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0FP3
PANTHER	PTHR11537	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01491	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01491
PRINTS	PR01494	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01494
PSORT	swissprot:KCNS1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNS1_HUMAN
PSORT-B	swissprot:KCNS1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNS1_HUMAN
PSORT2	swissprot:KCNS1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNS1_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF02214	http://pfam.xfam.org/family/PF02214
PharmGKB	PA30078	http://www.pharmgkb.org/do/serve?objId=PA30078&objCls=Gene
Phobius	swissprot:KCNS1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNS1_HUMAN
PhylomeDB	Q96KK3	http://phylomedb.org/?seqid=Q96KK3
ProteinModelPortal	Q96KK3	http://www.proteinmodelportal.org/query/uniprot/Q96KK3
PubMed	10484328	http://www.ncbi.nlm.nih.gov/pubmed/10484328
PubMed	11780052	http://www.ncbi.nlm.nih.gov/pubmed/11780052
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
RefSeq	NP_001309728	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001309728
RefSeq	NP_002242	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002242
SMART	SM00225	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225
STRING	9606.ENSP00000307694	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000307694&targetmode=cogs
SUPFAM	SSF54695	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54695
TCDB	1.A.1.2	http://www.tcdb.org/search/result.php?tc=1.A.1.2
UCSC	uc002xnc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002xnc&org=rat
UniGene	Hs.117780	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.117780
UniGene	Hs.563002	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.563002
UniProtKB	KCNS1_HUMAN	http://www.uniprot.org/uniprot/KCNS1_HUMAN
UniProtKB-AC	Q96KK3	http://www.uniprot.org/uniprot/Q96KK3
charge	swissprot:KCNS1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNS1_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG3713	http://eggnogapi.embl.de/nog_data/html/tree/KOG3713
epestfind	swissprot:KCNS1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNS1_HUMAN
garnier	swissprot:KCNS1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNS1_HUMAN
helixturnhelix	swissprot:KCNS1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNS1_HUMAN
hmoment	swissprot:KCNS1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNS1_HUMAN
iep	swissprot:KCNS1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNS1_HUMAN
inforesidue	swissprot:KCNS1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNS1_HUMAN
neXtProt	NX_Q96KK3	http://www.nextprot.org/db/entry/NX_Q96KK3
octanol	swissprot:KCNS1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNS1_HUMAN
pepcoil	swissprot:KCNS1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNS1_HUMAN
pepdigest	swissprot:KCNS1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNS1_HUMAN
pepinfo	swissprot:KCNS1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNS1_HUMAN
pepnet	swissprot:KCNS1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNS1_HUMAN
pepstats	swissprot:KCNS1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNS1_HUMAN
pepwheel	swissprot:KCNS1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNS1_HUMAN
pepwindow	swissprot:KCNS1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNS1_HUMAN
sigcleave	swissprot:KCNS1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNS1_HUMAN
## Database	ID	URL or Descriptions
# AltName	ABCD2_HUMAN	Adrenoleukodystrophy-like 1
# AltName	ABCD2_HUMAN	Adrenoleukodystrophy-related protein
# BioGrid	106727	5
# Ensembl	ENST00000308666	ENSP00000310688; ENSG00000173208
# FUNCTION	ABCD2_HUMAN	Probable transporter. 
# GO_component	GO:0005777	peroxisome; IDA:UniProtKB.
# GO_component	GO:0005778	peroxisomal membrane; TAS:Reactome.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_function	GO:0005324	long-chain fatty acid transporter activity; TAS:Reactome.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro.
# GO_function	GO:0042803	protein homodimerization activity; IDA:UniProtKB.
# GO_process	GO:0000038	very long-chain fatty acid metabolic process; IDA:UniProtKB.
# GO_process	GO:0006635	fatty acid beta-oxidation; IGI:UniProtKB.
# GO_process	GO:0032000	positive regulation of fatty acid beta-oxidation; IDA:UniProtKB.
# GO_process	GO:0042760	very long-chain fatty acid catabolic process; IGI:UniProtKB.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005777	peroxisome
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009056	catabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 1.
# Genevisible	Q9UBJ2	HS
# HGNC	HGNC:66	ABCD2
# IntAct	Q9UBJ2	2
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR011527	ABC1_TM_dom
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR027417	P-loop_NTPase
# InterPro	IPR031239	ABCD2
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko02010	ABC transporters
# KEGG_Pathway	ko04146	Peroxisome
# MIM	601081	gene
# Organism	ABCD2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11384:SF24	PTHR11384:SF24
# PIR	JC5712	JC5712
# PROSITE	PS00211	ABC_TRANSPORTER_1
# PROSITE	PS50893	ABC_TRANSPORTER_2
# PROSITE	PS50929	ABC_TM1F
# Pfam	PF00005	ABC_tran
# Pfam	PF06472	ABC_membrane_2
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-1369062	ABC transporters in lipid homeostasis
# RecName	ABCD2_HUMAN	ATP-binding cassette sub-family D member 2
# RefSeq	NP_005155	NM_005164.3
# RefSeq	XP_011536329	XM_011538027.2
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule	PRU00441}. 
# SIMILARITY	Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA
# SUBCELLULAR LOCATION	ABCD2_HUMAN	Peroxisome membrane; Multi-pass membrane protein. 
# SUBUNIT	ABCD2_HUMAN	Can form heterodimers with ABCD1/ALD and ABCD3/PMP70. Dimerization is necessary to form an active transporter. Interacts with PEX19. {ECO 0000269|PubMed 10551832, ECO 0000269|PubMed 10704444, ECO 0000269|PubMed 10777694}. 
# SUPFAM	SSF52540	SSF52540
# SUPFAM	SSF90123	SSF90123
# TCDB	3.A.1.203	the atp-binding cassette (abc) superfamily
# TISSUE SPECIFICITY	ABCD2_HUMAN	Predominantly expressed in brain and heart. 
# UCSC	uc001rmb	human
# WEB RESOURCE	ABCD2_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=Q9UBJ2";
# eggNOG	COG4178	LUCA
# eggNOG	KOG0064	Eukaryota
BLAST	swissprot:ABCD2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCD2_HUMAN
BioCyc	ZFISH:ENSG00000173208-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000173208-MONOMER
COXPRESdb	225	http://coxpresdb.jp/data/gene/225.shtml
CleanEx	HS_ABCD2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCD2
DOI	10.1006/bbrc.1997.7391	http://dx.doi.org/10.1006/bbrc.1997.7391
DOI	10.1006/bbrc.1999.0535	http://dx.doi.org/10.1006/bbrc.1999.0535
DOI	10.1006/bbrc.2000.2572	http://dx.doi.org/10.1006/bbrc.2000.2572
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.93.3.1265	http://dx.doi.org/10.1073/pnas.93.3.1265
DOI	10.1074/jbc.274.46.32738	http://dx.doi.org/10.1074/jbc.274.46.32738
DOI	10.1083/jcb.148.5.931	http://dx.doi.org/10.1083/jcb.148.5.931
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1164368	http://dx.doi.org/10.1126/science.1164368
EMBL	AF119822	http://www.ebi.ac.uk/ena/data/view/AF119822
EMBL	AF119823	http://www.ebi.ac.uk/ena/data/view/AF119823
EMBL	AF119824	http://www.ebi.ac.uk/ena/data/view/AF119824
EMBL	AF119825	http://www.ebi.ac.uk/ena/data/view/AF119825
EMBL	AF119826	http://www.ebi.ac.uk/ena/data/view/AF119826
EMBL	AF119827	http://www.ebi.ac.uk/ena/data/view/AF119827
EMBL	AF119828	http://www.ebi.ac.uk/ena/data/view/AF119828
EMBL	AF119829	http://www.ebi.ac.uk/ena/data/view/AF119829
EMBL	AF119830	http://www.ebi.ac.uk/ena/data/view/AF119830
EMBL	AF119831	http://www.ebi.ac.uk/ena/data/view/AF119831
EMBL	AJ000327	http://www.ebi.ac.uk/ena/data/view/AJ000327
EMBL	AK314254	http://www.ebi.ac.uk/ena/data/view/AK314254
EMBL	BC104901	http://www.ebi.ac.uk/ena/data/view/BC104901
EMBL	BC104903	http://www.ebi.ac.uk/ena/data/view/BC104903
EMBL	CH471111	http://www.ebi.ac.uk/ena/data/view/CH471111
EMBL	U28150	http://www.ebi.ac.uk/ena/data/view/U28150
Ensembl	ENST00000308666	http://www.ensembl.org/id/ENST00000308666
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005777	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005777
GO_component	GO:0005778	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005778
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0005324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005324
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_process	GO:0000038	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000038
GO_process	GO:0006635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006635
GO_process	GO:0032000	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032000
GO_process	GO:0042760	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042760
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005777	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005777
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCD2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCD2
GeneID	225	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=225
GeneTree	ENSGT00390000003950	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000003950
HGNC	HGNC:66	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:66
HOGENOM	HOG000206081	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000206081&db=HOGENOM6
HOVERGEN	HBG050438	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050438&db=HOVERGEN
HPA	HPA040336	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA040336
InParanoid	Q9UBJ2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UBJ2
IntAct	Q9UBJ2	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9UBJ2*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR011527	http://www.ebi.ac.uk/interpro/entry/IPR011527
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
InterPro	IPR031239	http://www.ebi.ac.uk/interpro/entry/IPR031239
Jabion	225	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=225
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:225	http://www.genome.jp/dbget-bin/www_bget?hsa:225
KEGG_Orthology	KO:K05676	http://www.genome.jp/dbget-bin/www_bget?KO:K05676
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
KEGG_Pathway	ko04146	http://www.genome.jp/kegg-bin/show_pathway?ko04146
MIM	601081	http://www.ncbi.nlm.nih.gov/omim/601081
OMA	HAYRTYF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HAYRTYF
OrthoDB	EOG091G04M1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G04M1
PANTHER	PTHR11384:SF24	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11384:SF24
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PROSITE	PS50929	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929
PSORT	swissprot:ABCD2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCD2_HUMAN
PSORT-B	swissprot:ABCD2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCD2_HUMAN
PSORT2	swissprot:ABCD2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCD2_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF06472	http://pfam.xfam.org/family/PF06472
PharmGKB	PA24401	http://www.pharmgkb.org/do/serve?objId=PA24401&objCls=Gene
Phobius	swissprot:ABCD2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCD2_HUMAN
PhylomeDB	Q9UBJ2	http://phylomedb.org/?seqid=Q9UBJ2
ProteinModelPortal	Q9UBJ2	http://www.proteinmodelportal.org/query/uniprot/Q9UBJ2
PubMed	10329405	http://www.ncbi.nlm.nih.gov/pubmed/10329405
PubMed	10551832	http://www.ncbi.nlm.nih.gov/pubmed/10551832
PubMed	10704444	http://www.ncbi.nlm.nih.gov/pubmed/10704444
PubMed	10777694	http://www.ncbi.nlm.nih.gov/pubmed/10777694
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18772397	http://www.ncbi.nlm.nih.gov/pubmed/18772397
PubMed	8577752	http://www.ncbi.nlm.nih.gov/pubmed/8577752
PubMed	9345306	http://www.ncbi.nlm.nih.gov/pubmed/9345306
Reactome	R-HSA-1369062	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1369062
RefSeq	NP_005155	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005155
RefSeq	XP_011536329	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011536329
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	Q9UBJ2	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9UBJ2
STRING	9606.ENSP00000310688	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000310688&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
SUPFAM	SSF90123	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123
TCDB	3.A.1.203	http://www.tcdb.org/search/result.php?tc=3.A.1.203
UCSC	uc001rmb	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001rmb&org=rat
UniGene	Hs.117852	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.117852
UniProtKB	ABCD2_HUMAN	http://www.uniprot.org/uniprot/ABCD2_HUMAN
UniProtKB-AC	Q9UBJ2	http://www.uniprot.org/uniprot/Q9UBJ2
charge	swissprot:ABCD2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCD2_HUMAN
eggNOG	COG4178	http://eggnogapi.embl.de/nog_data/html/tree/COG4178
eggNOG	KOG0064	http://eggnogapi.embl.de/nog_data/html/tree/KOG0064
epestfind	swissprot:ABCD2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCD2_HUMAN
garnier	swissprot:ABCD2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCD2_HUMAN
helixturnhelix	swissprot:ABCD2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCD2_HUMAN
hmoment	swissprot:ABCD2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCD2_HUMAN
iep	swissprot:ABCD2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCD2_HUMAN
inforesidue	swissprot:ABCD2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCD2_HUMAN
neXtProt	NX_Q9UBJ2	http://www.nextprot.org/db/entry/NX_Q9UBJ2
octanol	swissprot:ABCD2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCD2_HUMAN
pepcoil	swissprot:ABCD2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCD2_HUMAN
pepdigest	swissprot:ABCD2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCD2_HUMAN
pepinfo	swissprot:ABCD2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCD2_HUMAN
pepnet	swissprot:ABCD2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCD2_HUMAN
pepstats	swissprot:ABCD2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCD2_HUMAN
pepwheel	swissprot:ABCD2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCD2_HUMAN
pepwindow	swissprot:ABCD2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCD2_HUMAN
sigcleave	swissprot:ABCD2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCD2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	DSCR3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O14972-1; Sequence=Displayed; Name=2; IsoId=O14972-2; Sequence=VSP_056598; Note=No experimental confirmation available.; 
# AltName	DSCR3_HUMAN	Down syndrome critical region protein A
# BioGrid	115596	16
# CCDS	CCDS33553	-. [O14972-1]
# CCDS	CCDS82673	-. [O14972-2]
# ChiTaRS	DSCR3	human
# Ensembl	ENST00000309117	ENSP00000311399; ENSG00000157538. [O14972-1]
# Ensembl	ENST00000476950	ENSP00000419496; ENSG00000157538. [O14972-2]
# ExpressionAtlas	O14972	baseline and differential
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005768	endosome; IBA:GO_Central.
# GO_function	GO:0008565	protein transporter activity; IBA:GO_Central.
# GO_process	GO:0006886	intracellular protein transport; IBA:GO_Central.
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005768	endosome
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	O14972	HS
# HGNC	HGNC:3044	DSCR3
# IntAct	O14972	6
# InterPro	IPR014756	Ig_E-set
# InterPro	IPR028934	Vps26-related
# MIM	605298	gene
# Organism	DSCR3_HUMAN	Homo sapiens (Human)
# PIR	JC5698	JC5698
# Pfam	PF03643	Vps26
# Proteomes	UP000005640	Chromosome 21
# RecName	DSCR3_HUMAN	Down syndrome critical region protein 3
# RefSeq	NP_001317947	NM_001331018.1
# RefSeq	NP_001317951	NM_001331022.1
# RefSeq	NP_006043	NM_006052.1. [O14972-1]
# SIMILARITY	Belongs to the VPS26 family. {ECO	0000305}.
# SUPFAM	SSF81296	SSF81296
# TISSUE SPECIFICITY	DSCR3_HUMAN	Ubiquitously expressed. 
# UCSC	uc002ywf	human. [O14972-1]
# eggNOG	ENOG410XS9N	LUCA
# eggNOG	KOG2717	Eukaryota
BLAST	swissprot:DSCR3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:DSCR3_HUMAN
BioCyc	ZFISH:ENSG00000157538-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000157538-MONOMER
COXPRESdb	10311	http://coxpresdb.jp/data/gene/10311.shtml
CleanEx	HS_DSCR3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_DSCR3
DIP	DIP-47317N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47317N
DOI	10.1038/35012518	http://dx.doi.org/10.1038/35012518
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/oxfordjournals.jbchem.a021835	http://dx.doi.org/10.1093/oxfordjournals.jbchem.a021835
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AK300024	http://www.ebi.ac.uk/ena/data/view/AK300024
EMBL	AK312707	http://www.ebi.ac.uk/ena/data/view/AK312707
EMBL	AK316460	http://www.ebi.ac.uk/ena/data/view/AK316460
EMBL	AP001412	http://www.ebi.ac.uk/ena/data/view/AP001412
EMBL	AP001432	http://www.ebi.ac.uk/ena/data/view/AP001432
EMBL	BC110655	http://www.ebi.ac.uk/ena/data/view/BC110655
EMBL	CH471079	http://www.ebi.ac.uk/ena/data/view/CH471079
EMBL	D87343	http://www.ebi.ac.uk/ena/data/view/D87343
Ensembl	ENST00000309117	http://www.ensembl.org/id/ENST00000309117
Ensembl	ENST00000476950	http://www.ensembl.org/id/ENST00000476950
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0006886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006886
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	DSCR3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=DSCR3
GeneID	10311	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10311
GeneTree	ENSGT00390000009324	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000009324
H-InvDB	HIX0022605	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0022605
HGNC	HGNC:3044	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:3044
HOGENOM	HOG000294089	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294089&db=HOGENOM6
HOVERGEN	HBG051411	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051411&db=HOVERGEN
HPA	CAB016377	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB016377
HPA	HPA023288	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA023288
InParanoid	O14972	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O14972
IntAct	O14972	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O14972*
InterPro	IPR014756	http://www.ebi.ac.uk/interpro/entry/IPR014756
InterPro	IPR028934	http://www.ebi.ac.uk/interpro/entry/IPR028934
Jabion	10311	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10311
KEGG_Gene	hsa:10311	http://www.genome.jp/dbget-bin/www_bget?hsa:10311
MIM	605298	http://www.ncbi.nlm.nih.gov/omim/605298
MINT	MINT-8247532	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8247532
OMA	PLKLCRM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PLKLCRM
OrthoDB	EOG091G0FCI	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0FCI
PSORT	swissprot:DSCR3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:DSCR3_HUMAN
PSORT-B	swissprot:DSCR3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:DSCR3_HUMAN
PSORT2	swissprot:DSCR3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:DSCR3_HUMAN
Pfam	PF03643	http://pfam.xfam.org/family/PF03643
PharmGKB	PA27496	http://www.pharmgkb.org/do/serve?objId=PA27496&objCls=Gene
Phobius	swissprot:DSCR3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:DSCR3_HUMAN
PhylomeDB	O14972	http://phylomedb.org/?seqid=O14972
ProteinModelPortal	O14972	http://www.proteinmodelportal.org/query/uniprot/O14972
PubMed	10830953	http://www.ncbi.nlm.nih.gov/pubmed/10830953
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	9399594	http://www.ncbi.nlm.nih.gov/pubmed/9399594
RefSeq	NP_001317947	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001317947
RefSeq	NP_001317951	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001317951
RefSeq	NP_006043	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006043
SMR	O14972	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O14972
STRING	9606.ENSP00000311399	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000311399&targetmode=cogs
SUPFAM	SSF81296	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81296
UCSC	uc002ywf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ywf&org=rat
UniGene	Hs.369488	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.369488
UniProtKB	DSCR3_HUMAN	http://www.uniprot.org/uniprot/DSCR3_HUMAN
UniProtKB-AC	O14972	http://www.uniprot.org/uniprot/O14972
charge	swissprot:DSCR3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:DSCR3_HUMAN
eggNOG	ENOG410XS9N	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS9N
eggNOG	KOG2717	http://eggnogapi.embl.de/nog_data/html/tree/KOG2717
epestfind	swissprot:DSCR3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:DSCR3_HUMAN
garnier	swissprot:DSCR3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:DSCR3_HUMAN
helixturnhelix	swissprot:DSCR3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:DSCR3_HUMAN
hmoment	swissprot:DSCR3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:DSCR3_HUMAN
iep	swissprot:DSCR3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:DSCR3_HUMAN
inforesidue	swissprot:DSCR3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:DSCR3_HUMAN
neXtProt	NX_O14972	http://www.nextprot.org/db/entry/NX_O14972
octanol	swissprot:DSCR3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:DSCR3_HUMAN
pepcoil	swissprot:DSCR3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:DSCR3_HUMAN
pepdigest	swissprot:DSCR3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:DSCR3_HUMAN
pepinfo	swissprot:DSCR3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:DSCR3_HUMAN
pepnet	swissprot:DSCR3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:DSCR3_HUMAN
pepstats	swissprot:DSCR3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:DSCR3_HUMAN
pepwheel	swissprot:DSCR3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:DSCR3_HUMAN
pepwindow	swissprot:DSCR3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:DSCR3_HUMAN
sigcleave	swissprot:DSCR3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:DSCR3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	XPR1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UBH6-1; Sequence=Displayed; Name=2; IsoId=Q9UBH6-2; Sequence=VSP_030748; 
# AltName	XPR1_HUMAN	Protein SYG1 homolog
# AltName	XPR1_HUMAN	Xenotropic and polytropic murine leukemia virus receptor X3
# BioGrid	114647	42
# CAUTION	It is unclear whether its ability to act as a receptor for xenotropic and polytropic murine leukemia retroviruses is relevant in vivo and whether such viruses can infect human. {ECO	0000305}.
# CCDS	CCDS1340	-. [Q9UBH6-1]
# CCDS	CCDS44284	-. [Q9UBH6-2]
# DEVELOPMENTAL STAGE	XPR1_HUMAN	Expressed in fetal liver. {ECO 0000269|PubMed 9927670, ECO 0000269|PubMed 9990033}. 
# DISEASE	XPR1_HUMAN	Basal ganglia calcification, idiopathic, 6 (IBGC6) [MIM 616413]  A form of basal ganglia calcification, an autosomal dominant condition characterized by symmetric calcification in the basal ganglia and other brain regions. Affected individuals can either be asymptomatic or show a wide spectrum of neuropsychiatric symptoms, including parkinsonism, dystonia, tremor, ataxia, dementia, psychosis, seizures, and chronic headache. Serum levels of calcium, phosphate, alkaline phosphatase and parathyroid hormone are normal. The neuropathological hallmark of the disease is vascular and pericapillary calcification, mainly of calcium phosphate, in the affected brain areas. {ECO 0000269|PubMed 25938945}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	XPR1_HUMAN	The SPX domain has high affinity for inositol polyphosphates, such as myo-inositol hexakisphosphate and 5- diphospho-myo-inositol pentakisphosphate (5-InsP7). Its affinity for inorganic phosphate is tow to three orders of magnitude lower. {ECO 0000269|PubMed 27080106}. 
# Ensembl	ENST00000367589	ENSP00000356561; ENSG00000143324. [Q9UBH6-2]
# Ensembl	ENST00000367590	ENSP00000356562; ENSG00000143324. [Q9UBH6-1]
# ExpressionAtlas	Q9UBH6	baseline and differential
# FUNCTION	XPR1_HUMAN	Plays a role in phosphate homeostasis. Mediates phosphate export from the cell (PubMed 23791524, PubMed 25938945). Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5- InsP7); these are important intracellular signaling molecules (PubMed 27080106). {ECO 0000250|UniProtKB Q9Z0U0, ECO 0000269|PubMed 23791524, ECO 0000269|PubMed 25938945, ECO 0000269|PubMed 27080106}. 
# GO_component	GO:0005794	Golgi apparatus; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0031226	intrinsic component of plasma membrane; IDA:UniProtKB.
# GO_function	GO:0000822	inositol hexakisphosphate binding; IDA:UniProtKB.
# GO_function	GO:0001618	virus receptor activity; IMP:UniProtKB.
# GO_function	GO:0004872	receptor activity; TAS:ProtInc.
# GO_function	GO:0004888	transmembrane signaling receptor activity; TAS:ProtInc.
# GO_function	GO:0004930	G-protein coupled receptor activity; TAS:ProtInc.
# GO_function	GO:0015114	phosphate ion transmembrane transporter activity; IMP:UniProtKB.
# GO_function	GO:0015562	efflux transmembrane transporter activity; IMP:UniProtKB.
# GO_process	GO:0007186	G-protein coupled receptor signaling pathway; TAS:ProtInc.
# GO_process	GO:0009615	response to virus; IEA:Ensembl.
# GO_process	GO:0030643	cellular phosphate ion homeostasis; IMP:UniProtKB.
# GO_process	GO:0035435	phosphate ion transmembrane transport; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9UBH6	HS
# HGNC	HGNC:12827	XPR1
# IntAct	Q9UBH6	21
# InterPro	IPR004331	SPX_dom
# InterPro	IPR004342	EXS_C
# KEGG_Disease	H01574	[Nervous system disease] Fahr's disease
# MIM	605237	gene
# MIM	616413	phenotype
# Organism	XPR1_HUMAN	Homo sapiens (Human)
# PDB	5IJH	X-ray; 2.43 A; A/B=1-207
# PIR	T42660	T42660
# PROSITE	PS51380	EXS
# PROSITE	PS51382	SPX
# Pfam	PF03105	SPX; 3
# Pfam	PF03124	EXS
# Proteomes	UP000005640	Chromosome 1
# RecName	XPR1_HUMAN	Xenotropic and polytropic retrovirus receptor 1
# RefSeq	NP_001129141	NM_001135669.1. [Q9UBH6-2]
# RefSeq	NP_004727	NM_004736.3. [Q9UBH6-1]
# SIMILARITY	Belongs to the SYG1 (TC 2.A.94) family. {ECO	0000305}. 
# SIMILARITY	Contains 1 EXS domain. {ECO:0000255|PROSITE- ProRule	PRU00712}. 
# SIMILARITY	Contains 1 SPX domain. {ECO:0000255|PROSITE- ProRule	PRU00714}. 
# SUBCELLULAR LOCATION	XPR1_HUMAN	Cell membrane {ECO 0000269|PubMed 23791524}; Multi-pass membrane protein {ECO 0000305}. 
# TISSUE SPECIFICITY	XPR1_HUMAN	Widely expressed. Detected in spleen, lymph node, thymus, leukocytes, bone marrow, heart, kidney, pancreas and skeletal muscle. {ECO 0000269|PubMed 9927670, ECO 0000269|PubMed 9990033}. 
# UCSC	uc001goi	human. [Q9UBH6-1]
# eggNOG	COG5409	LUCA
# eggNOG	KOG1162	Eukaryota
BLAST	swissprot:XPR1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:XPR1_HUMAN
BioCyc	ZFISH:ENSG00000143324-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000143324-MONOMER
COXPRESdb	9213	http://coxpresdb.jp/data/gene/9213.shtml
CleanEx	HS_XPR1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_XPR1
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.celrep.2013.05.035	http://dx.doi.org/10.1016/j.celrep.2013.05.035
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/6005	http://dx.doi.org/10.1038/6005
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng.3289	http://dx.doi.org/10.1038/ng.3289
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.96.3.927	http://dx.doi.org/10.1073/pnas.96.3.927
DOI	10.1073/pnas.96.4.1385	http://dx.doi.org/10.1073/pnas.96.4.1385
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.aad9858	http://dx.doi.org/10.1126/science.aad9858
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AF089744	http://www.ebi.ac.uk/ena/data/view/AF089744
EMBL	AF099082	http://www.ebi.ac.uk/ena/data/view/AF099082
EMBL	AF115389	http://www.ebi.ac.uk/ena/data/view/AF115389
EMBL	AL133058	http://www.ebi.ac.uk/ena/data/view/AL133058
EMBL	AL137583	http://www.ebi.ac.uk/ena/data/view/AL137583
EMBL	AL162431	http://www.ebi.ac.uk/ena/data/view/AL162431
EMBL	AL162431	http://www.ebi.ac.uk/ena/data/view/AL162431
EMBL	AL162431	http://www.ebi.ac.uk/ena/data/view/AL162431
EMBL	AL162431	http://www.ebi.ac.uk/ena/data/view/AL162431
EMBL	AL162431	http://www.ebi.ac.uk/ena/data/view/AL162431
EMBL	AL162431	http://www.ebi.ac.uk/ena/data/view/AL162431
EMBL	AL358434	http://www.ebi.ac.uk/ena/data/view/AL358434
EMBL	AL358434	http://www.ebi.ac.uk/ena/data/view/AL358434
EMBL	AL358434	http://www.ebi.ac.uk/ena/data/view/AL358434
EMBL	AL358434	http://www.ebi.ac.uk/ena/data/view/AL358434
EMBL	AL358434	http://www.ebi.ac.uk/ena/data/view/AL358434
EMBL	AL358434	http://www.ebi.ac.uk/ena/data/view/AL358434
EMBL	AL590085	http://www.ebi.ac.uk/ena/data/view/AL590085
EMBL	AL590085	http://www.ebi.ac.uk/ena/data/view/AL590085
EMBL	AL590085	http://www.ebi.ac.uk/ena/data/view/AL590085
EMBL	AL590085	http://www.ebi.ac.uk/ena/data/view/AL590085
EMBL	AL590085	http://www.ebi.ac.uk/ena/data/view/AL590085
EMBL	AL590085	http://www.ebi.ac.uk/ena/data/view/AL590085
EMBL	BC041142	http://www.ebi.ac.uk/ena/data/view/BC041142
EMBL	CH471067	http://www.ebi.ac.uk/ena/data/view/CH471067
Ensembl	ENST00000367589	http://www.ensembl.org/id/ENST00000367589
Ensembl	ENST00000367590	http://www.ensembl.org/id/ENST00000367590
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0031226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031226
GO_function	GO:0000822	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000822
GO_function	GO:0001618	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001618
GO_function	GO:0004872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004872
GO_function	GO:0004888	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004888
GO_function	GO:0004930	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004930
GO_function	GO:0015114	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015114
GO_function	GO:0015562	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015562
GO_process	GO:0007186	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007186
GO_process	GO:0009615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009615
GO_process	GO:0030643	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030643
GO_process	GO:0035435	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035435
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	XPR1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=XPR1
GeneID	9213	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9213
GeneTree	ENSGT00500000044895	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00500000044895
H-InvDB	HIX0001390	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0001390
HGNC	HGNC:12827	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:12827
HOGENOM	HOG000046196	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000046196&db=HOGENOM6
HOVERGEN	HBG108684	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108684&db=HOVERGEN
HPA	HPA016557	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA016557
InParanoid	Q9UBH6	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UBH6
IntAct	Q9UBH6	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9UBH6*
InterPro	IPR004331	http://www.ebi.ac.uk/interpro/entry/IPR004331
InterPro	IPR004342	http://www.ebi.ac.uk/interpro/entry/IPR004342
Jabion	9213	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9213
KEGG_Disease	H01574	http://www.genome.jp/dbget-bin/www_bget?H01574
KEGG_Gene	hsa:9213	http://www.genome.jp/dbget-bin/www_bget?hsa:9213
MIM	605237	http://www.ncbi.nlm.nih.gov/omim/605237
MIM	616413	http://www.ncbi.nlm.nih.gov/omim/616413
OMA	WTVQISI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WTVQISI
OrthoDB	EOG091G02HT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02HT
PDB	5IJH	http://www.ebi.ac.uk/pdbe-srv/view/entry/5IJH
PDBsum	5IJH	http://www.ebi.ac.uk/pdbsum/5IJH
PROSITE	PS51380	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51380
PROSITE	PS51382	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51382
PSORT	swissprot:XPR1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:XPR1_HUMAN
PSORT-B	swissprot:XPR1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:XPR1_HUMAN
PSORT2	swissprot:XPR1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:XPR1_HUMAN
Pfam	PF03105	http://pfam.xfam.org/family/PF03105
Pfam	PF03124	http://pfam.xfam.org/family/PF03124
PharmGKB	PA37420	http://www.pharmgkb.org/do/serve?objId=PA37420&objCls=Gene
Phobius	swissprot:XPR1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:XPR1_HUMAN
PhylomeDB	Q9UBH6	http://phylomedb.org/?seqid=Q9UBH6
ProteinModelPortal	Q9UBH6	http://www.proteinmodelportal.org/query/uniprot/Q9UBH6
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	23791524	http://www.ncbi.nlm.nih.gov/pubmed/23791524
PubMed	25938945	http://www.ncbi.nlm.nih.gov/pubmed/25938945
PubMed	27080106	http://www.ncbi.nlm.nih.gov/pubmed/27080106
PubMed	9927670	http://www.ncbi.nlm.nih.gov/pubmed/9927670
PubMed	9988277	http://www.ncbi.nlm.nih.gov/pubmed/9988277
PubMed	9990033	http://www.ncbi.nlm.nih.gov/pubmed/9990033
RefSeq	NP_001129141	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001129141
RefSeq	NP_004727	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004727
SMR	Q9UBH6	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9UBH6
STRING	9606.ENSP00000356562	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000356562&targetmode=cogs
UCSC	uc001goi	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001goi&org=rat
UniGene	Hs.227656	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.227656
UniProtKB	XPR1_HUMAN	http://www.uniprot.org/uniprot/XPR1_HUMAN
UniProtKB-AC	Q9UBH6	http://www.uniprot.org/uniprot/Q9UBH6
charge	swissprot:XPR1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:XPR1_HUMAN
eggNOG	COG5409	http://eggnogapi.embl.de/nog_data/html/tree/COG5409
eggNOG	KOG1162	http://eggnogapi.embl.de/nog_data/html/tree/KOG1162
epestfind	swissprot:XPR1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:XPR1_HUMAN
garnier	swissprot:XPR1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:XPR1_HUMAN
helixturnhelix	swissprot:XPR1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:XPR1_HUMAN
hmoment	swissprot:XPR1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:XPR1_HUMAN
iep	swissprot:XPR1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:XPR1_HUMAN
inforesidue	swissprot:XPR1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:XPR1_HUMAN
neXtProt	NX_Q9UBH6	http://www.nextprot.org/db/entry/NX_Q9UBH6
octanol	swissprot:XPR1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:XPR1_HUMAN
pepcoil	swissprot:XPR1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:XPR1_HUMAN
pepdigest	swissprot:XPR1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:XPR1_HUMAN
pepinfo	swissprot:XPR1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:XPR1_HUMAN
pepnet	swissprot:XPR1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:XPR1_HUMAN
pepstats	swissprot:XPR1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:XPR1_HUMAN
pepwheel	swissprot:XPR1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:XPR1_HUMAN
pepwindow	swissprot:XPR1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:XPR1_HUMAN
sigcleave	swissprot:XPR1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:XPR1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TRPC1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P48995-1; Sequence=Displayed; Name=Short; IsoId=P48995-2; Sequence=VSP_006560; 
# AltName	TRPC1_HUMAN	Transient receptor protein 1
# BioGrid	113071	16
# CCDS	CCDS3126	-. [P48995-2]
# CCDS	CCDS58856	-. [P48995-1]
# ChiTaRS	TRPC1	human
# Ensembl	ENST00000273482	ENSP00000273482; ENSG00000144935. [P48995-2]
# Ensembl	ENST00000476941	ENSP00000419313; ENSG00000144935. [P48995-1]
# Ensembl	ENST00000612385	ENSP00000481537; ENSG00000144935. [P48995-2]
# ExpressionAtlas	P48995	baseline and differential
# FUNCTION	TRPC1_HUMAN	Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. {ECO 0000269|PubMed 15016832}. 
# GO_component	GO:0005886	plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0043235	receptor complex; IDA:MGI.
# GO_function	GO:0005261	cation channel activity; EXP:Reactome.
# GO_function	GO:0005262	calcium channel activity; TAS:Reactome.
# GO_function	GO:0015279	store-operated calcium channel activity; TAS:ProtInc.
# GO_function	GO:0044325	ion channel binding; IPI:BHF-UCL.
# GO_function	GO:0070679	inositol 1,4,5 trisphosphate binding; IDA:BHF-UCL.
# GO_process	GO:0006816	calcium ion transport; TAS:ProtInc.
# GO_process	GO:0006828	manganese ion transport; IBA:GO_Central.
# GO_process	GO:0042438	melanin biosynthetic process; IDA:CACAO.
# GO_process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol; IDA:BHF-UCL.
# GO_process	GO:0051480	regulation of cytosolic calcium ion concentration; IDA:BHF-UCL.
# GO_process	GO:0051592	response to calcium ion; IDA:BHF-UCL.
# GO_process	GO:0070588	calcium ion transmembrane transport; TAS:Reactome.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0019748	secondary metabolic process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.25.40.20	-; 1.
# Genevisible	P48995	HS
# HGNC	HGNC:12333	TRPC1
# INTERACTION	TRPC1_HUMAN	Q13563 PKD2; NbExp=4; IntAct=EBI-9830970, EBI-7813714; 
# IntAct	P48995	37
# InterPro	IPR002110	Ankyrin_rpt
# InterPro	IPR002153	TRPC_channel
# InterPro	IPR004729	TRP_channel
# InterPro	IPR005457	TRPC1_channel
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR013555	TRP_dom
# InterPro	IPR020683	Ankyrin_rpt-contain_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04724	Glutamatergic synapse
# KEGG_Pathway	ko04726	Serotonergic synapse
# KEGG_Pathway	ko04972	Pancreatic secretion
# MIM	602343	gene
# Organism	TRPC1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10117	PTHR10117
# PIR	S68238	S68238
# PRINTS	PR01097	TRNSRECEPTRP
# PRINTS	PR01642	TRPCHANNEL1
# PTM	TRPC1_HUMAN	Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells. {ECO 0000269|PubMed 15016832}. 
# Pfam	PF00520	Ion_trans
# Pfam	PF08344	TRP_2
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-3295583	TRP channels
# Reactome	R-HSA-418890	Role of second messengers in netrin-1 signaling
# Reactome	R-HSA-5578775	Ion homeostasis
# Reactome	R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
# RecName	TRPC1_HUMAN	Short transient receptor potential channel 1
# RefSeq	NP_001238774	NM_001251845.1. [P48995-1]
# RefSeq	NP_003295	NM_003304.4. [P48995-2]
# SIMILARITY	Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 4 ANK repeats. {ECO	0000305}.
# SMART	SM00248	ANK; 3
# SUBCELLULAR LOCATION	TRPC1_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	TRPC1_HUMAN	Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC4 and/or TRPC5. Interacts with TRPC3, TRPC4 and TRPC5. Interacts with ITPR3. Interacts with MX1 and RNF24. Interacts with FKBP4. {ECO 0000250, ECO 0000269|PubMed 10766822, ECO 0000269|PubMed 12032305, ECO 0000269|PubMed 15757897, ECO 0000269|PubMed 17850865, ECO 0000269|PubMed 19945390}. 
# SUPFAM	SSF48403	SSF48403
# TCDB	1.A.4.1	the transient receptor potential ca(2+) channel (trp-cc) family
# TIGRFAMs	TIGR00870	trp
# TISSUE SPECIFICITY	TRPC1_HUMAN	Seems to be ubiquitous. 
# UCSC	uc003evb	human. [P48995-1]
# eggNOG	ENOG410XQ0Y	LUCA
# eggNOG	KOG3609	Eukaryota
BLAST	swissprot:TRPC1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TRPC1_HUMAN
BioCyc	ZFISH:ENSG00000144935-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000144935-MONOMER
COXPRESdb	7220	http://coxpresdb.jp/data/gene/7220.shtml
CleanEx	HS_TRPC1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TRPC1
DIP	DIP-35698N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35698N
DOI	10.1016/0014-5793(95)01038-G	http://dx.doi.org/10.1016/0014-5793(95)01038-G
DOI	10.1016/S0896-6273(00)80145-2	http://dx.doi.org/10.1016/S0896-6273(00)80145-2
DOI	10.1016/j.ceca.2007.07.009	http://dx.doi.org/10.1016/j.ceca.2007.07.009
DOI	10.1016/j.neuron.2009.09.025	http://dx.doi.org/10.1016/j.neuron.2009.09.025
DOI	10.1073/pnas.102596199	http://dx.doi.org/10.1073/pnas.102596199
DOI	10.1073/pnas.92.21.9652	http://dx.doi.org/10.1073/pnas.92.21.9652
DOI	10.1074/jbc.275.16.11934	http://dx.doi.org/10.1074/jbc.275.16.11934
DOI	10.1074/jbc.M313975200	http://dx.doi.org/10.1074/jbc.M313975200
DOI	10.1074/jbc.M500391200	http://dx.doi.org/10.1074/jbc.M500391200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1161/01.RES.88.1.84	http://dx.doi.org/10.1161/01.RES.88.1.84
EMBL	BC112338	http://www.ebi.ac.uk/ena/data/view/BC112338
EMBL	BC113953	http://www.ebi.ac.uk/ena/data/view/BC113953
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
EMBL	U31110	http://www.ebi.ac.uk/ena/data/view/U31110
EMBL	U31110	http://www.ebi.ac.uk/ena/data/view/U31110
EMBL	X89066	http://www.ebi.ac.uk/ena/data/view/X89066
EMBL	Z73903	http://www.ebi.ac.uk/ena/data/view/Z73903
Ensembl	ENST00000273482	http://www.ensembl.org/id/ENST00000273482
Ensembl	ENST00000476941	http://www.ensembl.org/id/ENST00000476941
Ensembl	ENST00000612385	http://www.ensembl.org/id/ENST00000612385
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0043235	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043235
GO_function	GO:0005261	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005261
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0015279	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015279
GO_function	GO:0044325	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044325
GO_function	GO:0070679	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070679
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0006828	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006828
GO_process	GO:0042438	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042438
GO_process	GO:0051281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051281
GO_process	GO:0051480	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051480
GO_process	GO:0051592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051592
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0019748	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019748
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.25.40.20	http://www.cathdb.info/version/latest/superfamily/1.25.40.20
GeneCards	TRPC1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TRPC1
GeneID	7220	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7220
GeneTree	ENSGT00760000119180	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119180
HGNC	HGNC:12333	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:12333
HOGENOM	HOG000020589	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000020589&db=HOGENOM6
HOVERGEN	HBG068337	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG068337&db=HOVERGEN
HPA	CAB009387	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB009387
HPA	HPA021130	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA021130
InParanoid	P48995	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P48995
IntAct	P48995	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P48995*
InterPro	IPR002110	http://www.ebi.ac.uk/interpro/entry/IPR002110
InterPro	IPR002153	http://www.ebi.ac.uk/interpro/entry/IPR002153
InterPro	IPR004729	http://www.ebi.ac.uk/interpro/entry/IPR004729
InterPro	IPR005457	http://www.ebi.ac.uk/interpro/entry/IPR005457
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR013555	http://www.ebi.ac.uk/interpro/entry/IPR013555
InterPro	IPR020683	http://www.ebi.ac.uk/interpro/entry/IPR020683
Jabion	7220	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7220
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:7220	http://www.genome.jp/dbget-bin/www_bget?hsa:7220
KEGG_Orthology	KO:K04964	http://www.genome.jp/dbget-bin/www_bget?KO:K04964
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
KEGG_Pathway	ko04726	http://www.genome.jp/kegg-bin/show_pathway?ko04726
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
MIM	602343	http://www.ncbi.nlm.nih.gov/omim/602343
OMA	FVAQSNC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FVAQSNC
OrthoDB	EOG091G029I	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G029I
PANTHER	PTHR10117	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10117
PRINTS	PR01097	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01097
PRINTS	PR01642	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01642
PSORT	swissprot:TRPC1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TRPC1_HUMAN
PSORT-B	swissprot:TRPC1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TRPC1_HUMAN
PSORT2	swissprot:TRPC1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TRPC1_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF08344	http://pfam.xfam.org/family/PF08344
PharmGKB	PA357	http://www.pharmgkb.org/do/serve?objId=PA357&objCls=Gene
Phobius	swissprot:TRPC1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TRPC1_HUMAN
PhylomeDB	P48995	http://phylomedb.org/?seqid=P48995
ProteinModelPortal	P48995	http://www.proteinmodelportal.org/query/uniprot/P48995
PubMed	10766822	http://www.ncbi.nlm.nih.gov/pubmed/10766822
PubMed	11139478	http://www.ncbi.nlm.nih.gov/pubmed/11139478
PubMed	12032305	http://www.ncbi.nlm.nih.gov/pubmed/12032305
PubMed	15016832	http://www.ncbi.nlm.nih.gov/pubmed/15016832
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15757897	http://www.ncbi.nlm.nih.gov/pubmed/15757897
PubMed	17850865	http://www.ncbi.nlm.nih.gov/pubmed/17850865
PubMed	19945390	http://www.ncbi.nlm.nih.gov/pubmed/19945390
PubMed	7568191	http://www.ncbi.nlm.nih.gov/pubmed/7568191
PubMed	7589464	http://www.ncbi.nlm.nih.gov/pubmed/7589464
PubMed	8663995	http://www.ncbi.nlm.nih.gov/pubmed/8663995
Reactome	R-HSA-3295583	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3295583
Reactome	R-HSA-418890	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418890
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
Reactome	R-HSA-983695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983695
RefSeq	NP_001238774	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001238774
RefSeq	NP_003295	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003295
SMART	SM00248	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00248
STRING	9606.ENSP00000273482	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000273482&targetmode=cogs
SUPFAM	SSF48403	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48403
TCDB	1.A.4.1	http://www.tcdb.org/search/result.php?tc=1.A.4.1
TIGRFAMs	TIGR00870	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00870
UCSC	uc003evb	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003evb&org=rat
UniGene	Hs.250687	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.250687
UniGene	Hs.684389	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.684389
UniProtKB	TRPC1_HUMAN	http://www.uniprot.org/uniprot/TRPC1_HUMAN
UniProtKB-AC	P48995	http://www.uniprot.org/uniprot/P48995
charge	swissprot:TRPC1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TRPC1_HUMAN
eggNOG	ENOG410XQ0Y	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ0Y
eggNOG	KOG3609	http://eggnogapi.embl.de/nog_data/html/tree/KOG3609
epestfind	swissprot:TRPC1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TRPC1_HUMAN
garnier	swissprot:TRPC1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TRPC1_HUMAN
helixturnhelix	swissprot:TRPC1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRPC1_HUMAN
hmoment	swissprot:TRPC1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TRPC1_HUMAN
iep	swissprot:TRPC1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TRPC1_HUMAN
inforesidue	swissprot:TRPC1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TRPC1_HUMAN
neXtProt	NX_P48995	http://www.nextprot.org/db/entry/NX_P48995
octanol	swissprot:TRPC1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TRPC1_HUMAN
pepcoil	swissprot:TRPC1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TRPC1_HUMAN
pepdigest	swissprot:TRPC1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TRPC1_HUMAN
pepinfo	swissprot:TRPC1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TRPC1_HUMAN
pepnet	swissprot:TRPC1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TRPC1_HUMAN
pepstats	swissprot:TRPC1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TRPC1_HUMAN
pepwheel	swissprot:TRPC1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TRPC1_HUMAN
pepwindow	swissprot:TRPC1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TRPC1_HUMAN
sigcleave	swissprot:TRPC1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TRPC1_HUMAN
## Database	ID	URL or Descriptions
# AltName	TAP1_HUMAN	ATP-binding cassette sub-family B member 2
# AltName	TAP1_HUMAN	Peptide supply factor 1
# AltName	TAP1_HUMAN	Peptide transporter PSF1
# AltName	TAP1_HUMAN	Peptide transporter TAP1
# AltName	TAP1_HUMAN	Peptide transporter involved in antigen processing 1
# AltName	TAP1_HUMAN	Really interesting new gene 4 protein
# BRENDA	3.6.3.43	2681
# BioGrid	112753	40
# CAUTION	It is uncertain whether Met-1 or Met-61 is the initiator. {ECO	0000305}. 
# ChiTaRS	TAP1	human
# DISEASE	TAP1_HUMAN	Bare lymphocyte syndrome 1 (BLS1) [MIM 604571]  A HLA class I deficiency. Contrary to bare lymphocyte syndromes type 2 and type 3, which are characterized by early-onset severe combined immunodeficiency, class I antigen deficiencies are not accompanied by particular pathologic manifestations during the first years of life. Systemic infections have not been described. Chronic bacterial infections, often beginning in the first decade of life, are restricted to the respiratory tract. {ECO 0000269|PubMed 10074494}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	TAP1_HUMAN	The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2. 
# DrugBank	DB01259	Lapatinib
# Ensembl	ENST00000354258	ENSP00000346206; ENSG00000168394
# Ensembl	ENST00000383235	ENSP00000372722; ENSG00000206297
# Ensembl	ENST00000414467	ENSP00000405356; ENSG00000226173
# Ensembl	ENST00000418205	ENSP00000401149; ENSG00000227816
# Ensembl	ENST00000424897	ENSP00000413080; ENSG00000230705
# Ensembl	ENST00000439781	ENSP00000415660; ENSG00000224212
# Ensembl	ENST00000440894	ENSP00000402316; ENSG00000232367
# ExpressionAtlas	Q03518	baseline and differential
# FUNCTION	TAP1_HUMAN	Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules. 
# GO_component	GO:0005739	mitochondrion; IEA:Ensembl.
# GO_component	GO:0005789	endoplasmic reticulum membrane; TAS:Reactome.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IDA:UniProtKB.
# GO_component	GO:0030176	integral component of endoplasmic reticulum membrane; IDA:UniProtKB.
# GO_component	GO:0042825	TAP complex; IDA:UniProtKB.
# GO_component	GO:0043657	host cell; IEA:GOC.
# GO_function	GO:0005524	ATP binding; IDA:UniProtKB.
# GO_function	GO:0015197	peptide transporter activity; IMP:UniProtKB.
# GO_function	GO:0015433	peptide antigen-transporting ATPase activity; IEA:Ensembl.
# GO_function	GO:0023029	MHC class Ib protein binding; IPI:UniProtKB.
# GO_function	GO:0042605	peptide antigen binding; NAS:UniProtKB.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; IBA:GO_Central.
# GO_function	GO:0042803	protein homodimerization activity; ISS:UniProtKB.
# GO_function	GO:0043531	ADP binding; IDA:UniProtKB.
# GO_function	GO:0046978	TAP1 binding; ISS:UniProtKB.
# GO_function	GO:0046979	TAP2 binding; IPI:UniProtKB.
# GO_process	GO:0002250	adaptive immune response; IEA:UniProtKB-KW.
# GO_process	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome.
# GO_process	GO:0002481	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; IBA:GO_Central.
# GO_process	GO:0002485	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; IBA:GO_Central.
# GO_process	GO:0002489	antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; IBA:GO_Central.
# GO_process	GO:0002591	positive regulation of antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central.
# GO_process	GO:0006952	defense response; IEA:Ensembl.
# GO_process	GO:0015833	peptide transport; IMP:UniProtKB.
# GO_process	GO:0019060	intracellular transport of viral protein in host cell; IMP:UniProtKB.
# GO_process	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I; IMP:UniProtKB.
# GO_process	GO:0046967	cytosol to ER transport; IMP:UniProtKB.
# GO_process	GO:0055085	transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 1.
# Genevisible	Q03518	HS
# HGNC	HGNC:43	TAP1
# INDUCTION	TAP1_HUMAN	By IFNG/IFN-gamma. 
# INTERACTION	TAP1_HUMAN	P0C739 BNLF2a (xeno); NbExp=9; IntAct=EBI-747259, EBI-9346744; P27797 CALR; NbExp=2; IntAct=EBI-747259, EBI-1049597; Q77CE4 gN (xeno); NbExp=6; IntAct=EBI-747259, EBI-11303846; P07237 P4HB; NbExp=4; IntAct=EBI-747259, EBI-395883; P30101 PDIA3; NbExp=4; IntAct=EBI-747259, EBI-979862; Q03519 TAP2; NbExp=15; IntAct=EBI-747259, EBI-780781; O15533 TAPBP; NbExp=14; IntAct=EBI-747259, EBI-874801; Q13769 THOC5; NbExp=4; IntAct=EBI-747259, EBI-5280316; 
# IntAct	Q03518	41
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR011527	ABC1_TM_dom
# InterPro	IPR013305	ABC_Tap-like
# InterPro	IPR013306	Tap1/ABCB2
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Disease	H00093	[Primary immunodeficiency] CD8 deficiency
# KEGG_Disease	H00984	[Inherited metabolic disease; Immune system disease] Bare lymphocyte syndrome (BLS) type1
# KEGG_Pathway	ko02010	ABC transporters
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko04612	Antigen processing and presentation
# KEGG_Pathway	ko05168	Herpes simplex infection
# KEGG_Pathway	ko05340	Primary immunodeficiency
# MIM	170260	gene
# MIM	604571	phenotype
# Organism	TAP1_HUMAN	Homo sapiens (Human)
# Orphanet	34592	Immunodeficiency by defective expression of HLA class 1
# PANTHER	PTHR24221:SF249	PTHR24221:SF249; 2
# PDB	1JJ7	X-ray; 2.40 A; A=549-808
# PIR	S13427	A41538
# POLYMORPHISM	TAP1_HUMAN	There are five common alleles; TAP1*01 01 (PSF1A), TAP1*02 01 (PSF1B), TAP1*03 01 (PSF1C), TAP1*01 04 and TAP1*x. The sequence of TAP1*01 01 is shown here. {ECO 0000269|PubMed 11250043, ECO 0000269|PubMed 12878362, ECO 0000269|PubMed 1570316, ECO 0000269|PubMed 8168860, ECO 0000269|PubMed 8248212}. 
# PROSITE	PS00211	ABC_TRANSPORTER_1
# PROSITE	PS50893	ABC_TRANSPORTER_2
# PROSITE	PS50929	ABC_TM1F
# Pfam	PF00005	ABC_tran
# Pfam	PF00664	ABC_membrane
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-1236974	ER-Phagosome pathway
# Reactome	R-HSA-983170:Antigen Presentation	 Folding, assembly and peptide loading of class I MHC
# RecName	TAP1_HUMAN	Antigen peptide transporter 1
# RefSeq	NP_000584	NM_000593.5
# RefSeq	NP_001278951	NM_001292022.1
# SEQUENCE CAUTION	Sequence=CAA47025.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA60785.1; Type=Erroneous initiation; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule	PRU00441}. 
# SIMILARITY	Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA
# SUBCELLULAR LOCATION	TAP1_HUMAN	Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=The transmembrane segments seem to form a pore in the membrane. 
# SUBUNIT	TAP1_HUMAN	Heterodimer of TAP1 and TAP2. Interacts with Epstein-Barr virus BNLF2a. Interacts with herpes simplex virus ICP47 (PubMed 7760936). Interacts with PSMB5 and PSMB8. {ECO 0000269|PubMed 15488952, ECO 0000269|PubMed 19201886, ECO 0000269|PubMed 7760936}. 
# SUPFAM	SSF52540	SSF52540
# SUPFAM	SSF90123	SSF90123
# TCDB	3.A.1.209	the atp-binding cassette (abc) superfamily
# TIGRFAMs	TIGR00958	3a01208
# UCSC	uc003ocg	human
# WEB RESOURCE	TAP1_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=Q03518";
# WEB RESOURCE	TAP1_HUMAN	Name=TAP1base; Note=TAP1 mutation db; URL="http //structure.bmc.lu.se/idbase/TAP1base/"; 
# eggNOG	COG1132	LUCA
# eggNOG	KOG0058	Eukaryota
BLAST	swissprot:TAP1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TAP1_HUMAN
BioCyc	ZFISH:ENSG00000168394-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000168394-MONOMER
COXPRESdb	6890	http://coxpresdb.jp/data/gene/6890.shtml
CleanEx	HS_TAP1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TAP1
DIP	DIP-35626N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35626N
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/jmbi.1996.0001	http://dx.doi.org/10.1006/jmbi.1996.0001
DOI	10.1007/BF00189240	http://dx.doi.org/10.1007/BF00189240
DOI	10.1016/0022-2836(92)90832-5	http://dx.doi.org/10.1016/0022-2836(92)90832-5
DOI	10.1016/S0198-8859(00)00259-7	http://dx.doi.org/10.1016/S0198-8859(00)00259-7
DOI	10.1016/S0198-8859(03)00110-1	http://dx.doi.org/10.1016/S0198-8859(03)00110-1
DOI	10.1016/S1074-7613(00)80349-0	http://dx.doi.org/10.1016/S1074-7613(00)80349-0
DOI	10.1016/j.molimm.2004.07.005	http://dx.doi.org/10.1016/j.molimm.2004.07.005
DOI	10.1038/348741a0	http://dx.doi.org/10.1038/348741a0
DOI	10.1038/348744a0	http://dx.doi.org/10.1038/348744a0
DOI	10.1038/375415a0	http://dx.doi.org/10.1038/375415a0
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng0696-210	http://dx.doi.org/10.1038/ng0696-210
DOI	10.1073/pnas.88.22.10094	http://dx.doi.org/10.1073/pnas.88.22.10094
DOI	10.1073/pnas.89.9.3932	http://dx.doi.org/10.1073/pnas.89.9.3932
DOI	10.1073/pnas.90.23.11079	http://dx.doi.org/10.1073/pnas.90.23.11079
DOI	10.1093/emboj/20.17.4964	http://dx.doi.org/10.1093/emboj/20.17.4964
DOI	10.1093/emboj/20.3.387	http://dx.doi.org/10.1093/emboj/20.3.387
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1172/JCI5335	http://dx.doi.org/10.1172/JCI5335
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.4049/jimmunol.0803218	http://dx.doi.org/10.4049/jimmunol.0803218
DrugBank	DB01259	http://www.drugbank.ca/drugs/DB01259
EMBL	AL669918	http://www.ebi.ac.uk/ena/data/view/AL669918
EMBL	AL671681	http://www.ebi.ac.uk/ena/data/view/AL671681
EMBL	AL935043	http://www.ebi.ac.uk/ena/data/view/AL935043
EMBL	BC014081	http://www.ebi.ac.uk/ena/data/view/BC014081
EMBL	BX927138	http://www.ebi.ac.uk/ena/data/view/BX927138
EMBL	CH471081	http://www.ebi.ac.uk/ena/data/view/CH471081
EMBL	CR753889	http://www.ebi.ac.uk/ena/data/view/CR753889
EMBL	CR762476	http://www.ebi.ac.uk/ena/data/view/CR762476
EMBL	CR933844	http://www.ebi.ac.uk/ena/data/view/CR933844
EMBL	L21204	http://www.ebi.ac.uk/ena/data/view/L21204
EMBL	L21205	http://www.ebi.ac.uk/ena/data/view/L21205
EMBL	L21206	http://www.ebi.ac.uk/ena/data/view/L21206
EMBL	L21207	http://www.ebi.ac.uk/ena/data/view/L21207
EMBL	L21208	http://www.ebi.ac.uk/ena/data/view/L21208
EMBL	S70274	http://www.ebi.ac.uk/ena/data/view/S70274
EMBL	X57521	http://www.ebi.ac.uk/ena/data/view/X57521
EMBL	X57522	http://www.ebi.ac.uk/ena/data/view/X57522
EMBL	X66401	http://www.ebi.ac.uk/ena/data/view/X66401
EMBL	X87344	http://www.ebi.ac.uk/ena/data/view/X87344
Ensembl	ENST00000354258	http://www.ensembl.org/id/ENST00000354258
Ensembl	ENST00000383235	http://www.ensembl.org/id/ENST00000383235
Ensembl	ENST00000414467	http://www.ensembl.org/id/ENST00000414467
Ensembl	ENST00000418205	http://www.ensembl.org/id/ENST00000418205
Ensembl	ENST00000424897	http://www.ensembl.org/id/ENST00000424897
Ensembl	ENST00000439781	http://www.ensembl.org/id/ENST00000439781
Ensembl	ENST00000440894	http://www.ensembl.org/id/ENST00000440894
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030176	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030176
GO_component	GO:0042825	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042825
GO_component	GO:0043657	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043657
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0015197	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015197
GO_function	GO:0015433	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015433
GO_function	GO:0023029	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0023029
GO_function	GO:0042605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042605
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_function	GO:0043531	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043531
GO_function	GO:0046978	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046978
GO_function	GO:0046979	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046979
GO_process	GO:0002250	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002250
GO_process	GO:0002474	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002474
GO_process	GO:0002481	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002481
GO_process	GO:0002485	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002485
GO_process	GO:0002489	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002489
GO_process	GO:0002591	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002591
GO_process	GO:0006952	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006952
GO_process	GO:0015833	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015833
GO_process	GO:0019060	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019060
GO_process	GO:0019885	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019885
GO_process	GO:0046967	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046967
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	TAP1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TAP1
GeneID	6890	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6890
GeneTree	ENSGT00550000074497	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074497
HGNC	HGNC:43	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:43
HOVERGEN	HBG008358	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG008358&db=HOVERGEN
HPA	CAB009516	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB009516
InParanoid	Q03518	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q03518
IntAct	Q03518	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q03518*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR011527	http://www.ebi.ac.uk/interpro/entry/IPR011527
InterPro	IPR013305	http://www.ebi.ac.uk/interpro/entry/IPR013305
InterPro	IPR013306	http://www.ebi.ac.uk/interpro/entry/IPR013306
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	6890	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6890
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Disease	H00093	http://www.genome.jp/dbget-bin/www_bget?H00093
KEGG_Disease	H00984	http://www.genome.jp/dbget-bin/www_bget?H00984
KEGG_Gene	hsa:6890	http://www.genome.jp/dbget-bin/www_bget?hsa:6890
KEGG_Orthology	KO:K05653	http://www.genome.jp/dbget-bin/www_bget?KO:K05653
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko04612	http://www.genome.jp/kegg-bin/show_pathway?ko04612
KEGG_Pathway	ko05168	http://www.genome.jp/kegg-bin/show_pathway?ko05168
KEGG_Pathway	ko05340	http://www.genome.jp/kegg-bin/show_pathway?ko05340
MIM	170260	http://www.ncbi.nlm.nih.gov/omim/170260
MIM	604571	http://www.ncbi.nlm.nih.gov/omim/604571
MINT	MINT-1477433	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1477433
OMA	CLGEMAI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CLGEMAI
Orphanet	34592	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=34592
OrthoDB	EOG091G05Q9	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05Q9
PANTHER	PTHR24221:SF249	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24221:SF249
PDB	1JJ7	http://www.ebi.ac.uk/pdbe-srv/view/entry/1JJ7
PDBsum	1JJ7	http://www.ebi.ac.uk/pdbsum/1JJ7
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PROSITE	PS50929	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929
PSORT	swissprot:TAP1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TAP1_HUMAN
PSORT-B	swissprot:TAP1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TAP1_HUMAN
PSORT2	swissprot:TAP1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TAP1_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF00664	http://pfam.xfam.org/family/PF00664
PharmGKB	PA35021	http://www.pharmgkb.org/do/serve?objId=PA35021&objCls=Gene
Phobius	swissprot:TAP1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TAP1_HUMAN
PhylomeDB	Q03518	http://phylomedb.org/?seqid=Q03518
ProteinModelPortal	Q03518	http://www.proteinmodelportal.org/query/uniprot/Q03518
PubMed	10074494	http://www.ncbi.nlm.nih.gov/pubmed/10074494
PubMed	10227971	http://www.ncbi.nlm.nih.gov/pubmed/10227971
PubMed	11157746	http://www.ncbi.nlm.nih.gov/pubmed/11157746
PubMed	11250043	http://www.ncbi.nlm.nih.gov/pubmed/11250043
PubMed	11532960	http://www.ncbi.nlm.nih.gov/pubmed/11532960
PubMed	12878362	http://www.ncbi.nlm.nih.gov/pubmed/12878362
PubMed	1453454	http://www.ncbi.nlm.nih.gov/pubmed/1453454
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	15488952	http://www.ncbi.nlm.nih.gov/pubmed/15488952
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	1570316	http://www.ncbi.nlm.nih.gov/pubmed/1570316
PubMed	19201886	http://www.ncbi.nlm.nih.gov/pubmed/19201886
PubMed	1946428	http://www.ncbi.nlm.nih.gov/pubmed/1946428
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	2259383	http://www.ncbi.nlm.nih.gov/pubmed/2259383
PubMed	2259384	http://www.ncbi.nlm.nih.gov/pubmed/2259384
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	7760936	http://www.ncbi.nlm.nih.gov/pubmed/7760936
PubMed	8168860	http://www.ncbi.nlm.nih.gov/pubmed/8168860
PubMed	8248212	http://www.ncbi.nlm.nih.gov/pubmed/8248212
PubMed	8568858	http://www.ncbi.nlm.nih.gov/pubmed/8568858
PubMed	8640228	http://www.ncbi.nlm.nih.gov/pubmed/8640228
PubMed	8670825	http://www.ncbi.nlm.nih.gov/pubmed/8670825
PubMed	8955196	http://www.ncbi.nlm.nih.gov/pubmed/8955196
PubMed	9175839	http://www.ncbi.nlm.nih.gov/pubmed/9175839
PubMed	9310490	http://www.ncbi.nlm.nih.gov/pubmed/9310490
Reactome	R-HSA-1236974	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1236974
Reactome	R-HSA-983170	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983170
RefSeq	NP_000584	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000584
RefSeq	NP_001278951	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001278951
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	Q03518	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q03518
STRING	9606.ENSP00000346206	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000346206&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
SUPFAM	SSF90123	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123
TCDB	3.A.1.209	http://www.tcdb.org/search/result.php?tc=3.A.1.209
TIGRFAMs	TIGR00958	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00958
UCSC	uc003ocg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ocg&org=rat
UniGene	Hs.352018	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.352018
UniGene	Hs.731555	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.731555
UniProtKB	TAP1_HUMAN	http://www.uniprot.org/uniprot/TAP1_HUMAN
UniProtKB-AC	Q03518	http://www.uniprot.org/uniprot/Q03518
charge	swissprot:TAP1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TAP1_HUMAN
eggNOG	COG1132	http://eggnogapi.embl.de/nog_data/html/tree/COG1132
eggNOG	KOG0058	http://eggnogapi.embl.de/nog_data/html/tree/KOG0058
epestfind	swissprot:TAP1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TAP1_HUMAN
garnier	swissprot:TAP1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TAP1_HUMAN
helixturnhelix	swissprot:TAP1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TAP1_HUMAN
hmoment	swissprot:TAP1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TAP1_HUMAN
iep	swissprot:TAP1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TAP1_HUMAN
inforesidue	swissprot:TAP1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TAP1_HUMAN
neXtProt	NX_Q03518	http://www.nextprot.org/db/entry/NX_Q03518
octanol	swissprot:TAP1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TAP1_HUMAN
pepcoil	swissprot:TAP1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TAP1_HUMAN
pepdigest	swissprot:TAP1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TAP1_HUMAN
pepinfo	swissprot:TAP1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TAP1_HUMAN
pepnet	swissprot:TAP1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TAP1_HUMAN
pepstats	swissprot:TAP1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TAP1_HUMAN
pepwheel	swissprot:TAP1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TAP1_HUMAN
pepwindow	swissprot:TAP1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TAP1_HUMAN
sigcleave	swissprot:TAP1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TAP1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ZNT6_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q6NXT4-1; Sequence=Displayed; Name=2; IsoId=Q6NXT4-2; Sequence=VSP_029861; Note=No experimental confirmation available.; Name=4; IsoId=Q6NXT4-4; Sequence=VSP_045198; Note=No experimental confirmation available.; Name=3; IsoId=Q6NXT4-3; Sequence=VSP_029862; Note=No experimental confirmation available.; 
# AltName	ZNT6_HUMAN	Solute carrier family 30 member 6
# BioGrid	120806	22
# CCDS	CCDS1780	-. [Q6NXT4-1]
# CCDS	CCDS54341	-. [Q6NXT4-2]
# CCDS	CCDS54342	-. [Q6NXT4-3]
# CCDS	CCDS54343	-. [Q6NXT4-4]
# ChiTaRS	SLC30A6	human
# Ensembl	ENST00000282587	ENSP00000282587; ENSG00000152683. [Q6NXT4-1]
# Ensembl	ENST00000357055	ENSP00000349563; ENSG00000152683. [Q6NXT4-4]
# Ensembl	ENST00000379343	ENSP00000368648; ENSG00000152683. [Q6NXT4-2]
# Ensembl	ENST00000435660	ENSP00000399005; ENSG00000152683. [Q6NXT4-3]
# ExpressionAtlas	Q6NXT4	baseline and differential
# FUNCTION	ZNT6_HUMAN	Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment. {ECO 0000250}. 
# GO_component	GO:0000139	Golgi membrane; TAS:Reactome.
# GO_component	GO:0005794	Golgi apparatus; IDA:BHF-UCL.
# GO_component	GO:0016020	membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005385	zinc ion transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0010043	response to zinc ion; IBA:GO_Central.
# GO_process	GO:0061088	regulation of sequestering of zinc ion; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.20.1510.10	-; 1.
# Genevisible	Q6NXT4	HS
# HGNC	HGNC:19305	SLC30A6
# IntAct	Q6NXT4	4
# InterPro	IPR002524	Cation_efflux
# InterPro	IPR027469	Cation_efflux_TMD
# KEGG_Brite	ko02001	Solute carrier family
# MIM	611148	gene
# MISCELLANEOUS	Seems to have lost most of the histidine residues in the loop between the fourth and fifth transmembrane regions and appears to exert transport function by forming complexes with ZNT5. {ECO	0000250}. 
# Organism	ZNT6_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11562	PTHR11562; 2
# Pfam	PF01545	Cation_efflux
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-264876	Insulin processing
# Reactome	R-HSA-435368	Zinc efflux and compartmentalization by the SLC30 family
# RecName	ZNT6_HUMAN	Zinc transporter 6
# RefSeq	NP_001180442	NM_001193513.2. [Q6NXT4-2]
# RefSeq	NP_001180443	NM_001193514.2. [Q6NXT4-3]
# RefSeq	NP_001180444	NM_001193515.2. [Q6NXT4-4]
# RefSeq	NP_060434	NM_017964.4. [Q6NXT4-1]
# SEQUENCE CAUTION	Sequence=AAH32525.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	ZNT6_HUMAN	Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Found in vesicles. {ECO 0000250}. 
# SUBUNIT	Heterooligomer. Interacts with ZNT5 (By similarity). {ECO	0000250}. 
# TCDB	2.A.4.4	the cation diffusion facilitator (cdf) family
# TIGRFAMs	TIGR01297	CDF
# TISSUE SPECIFICITY	ZNT6_HUMAN	Expressed in brain; especially in cerebellum, hippocampus, parahippocampal gyrus, superior and middle temporal gyrus. Also expressed in B-cells, colon, eye, and lung. Lower expression was present in bone, brain, cervix, ear, heart, kidney, muscle, nerve, pancreas, prostate, skin, stomach, and testis. {ECO 0000269|PubMed 15154973, ECO 0000269|PubMed 16580781}. 
# UCSC	uc002roe	human. [Q6NXT4-1]
BLAST	swissprot:ZNT6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ZNT6_HUMAN
COXPRESdb	55676	http://coxpresdb.jp/data/gene/55676.shtml
CleanEx	HS_SLC30A6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC30A6
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1016/j.neuroscience.2006.02.049	http://dx.doi.org/10.1016/j.neuroscience.2006.02.049
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-5-32	http://dx.doi.org/10.1186/1471-2164-5-32
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AK055663	http://www.ebi.ac.uk/ena/data/view/AK055663
EMBL	AK304225	http://www.ebi.ac.uk/ena/data/view/AK304225
EMBL	AL121653	http://www.ebi.ac.uk/ena/data/view/AL121653
EMBL	AL121658	http://www.ebi.ac.uk/ena/data/view/AL121658
EMBL	BC032525	http://www.ebi.ac.uk/ena/data/view/BC032525
EMBL	BC066903	http://www.ebi.ac.uk/ena/data/view/BC066903
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
EMBL	EF560719	http://www.ebi.ac.uk/ena/data/view/EF560719
EMBL	EF560726	http://www.ebi.ac.uk/ena/data/view/EF560726
Ensembl	ENST00000282587	http://www.ensembl.org/id/ENST00000282587
Ensembl	ENST00000357055	http://www.ensembl.org/id/ENST00000357055
Ensembl	ENST00000379343	http://www.ensembl.org/id/ENST00000379343
Ensembl	ENST00000435660	http://www.ensembl.org/id/ENST00000435660
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005385
GO_process	GO:0010043	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010043
GO_process	GO:0061088	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061088
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.20.1510.10	http://www.cathdb.info/version/latest/superfamily/1.20.1510.10
GeneCards	SLC30A6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC30A6
GeneID	55676	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55676
GeneTree	ENSGT00630000089781	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00630000089781
H-InvDB	HIX0001954	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0001954
HGNC	HGNC:19305	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:19305
HOGENOM	HOG000060341	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000060341&db=HOGENOM6
HOVERGEN	HBG106400	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG106400&db=HOVERGEN
HPA	HPA055032	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA055032
HPA	HPA057328	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA057328
InParanoid	Q6NXT4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6NXT4
IntAct	Q6NXT4	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q6NXT4*
InterPro	IPR002524	http://www.ebi.ac.uk/interpro/entry/IPR002524
InterPro	IPR027469	http://www.ebi.ac.uk/interpro/entry/IPR027469
Jabion	55676	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55676
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:55676	http://www.genome.jp/dbget-bin/www_bget?hsa:55676
KEGG_Orthology	KO:K14693	http://www.genome.jp/dbget-bin/www_bget?KO:K14693
MIM	611148	http://www.ncbi.nlm.nih.gov/omim/611148
OMA	PSRYGTN	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PSRYGTN
OrthoDB	EOG091G0MKP	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0MKP
PANTHER	PTHR11562	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11562
PSORT	swissprot:ZNT6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ZNT6_HUMAN
PSORT-B	swissprot:ZNT6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ZNT6_HUMAN
PSORT2	swissprot:ZNT6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ZNT6_HUMAN
Pfam	PF01545	http://pfam.xfam.org/family/PF01545
PharmGKB	PA134923067	http://www.pharmgkb.org/do/serve?objId=PA134923067&objCls=Gene
Phobius	swissprot:ZNT6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ZNT6_HUMAN
PhylomeDB	Q6NXT4	http://phylomedb.org/?seqid=Q6NXT4
ProteinModelPortal	Q6NXT4	http://www.proteinmodelportal.org/query/uniprot/Q6NXT4
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15154973	http://www.ncbi.nlm.nih.gov/pubmed/15154973
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	16580781	http://www.ncbi.nlm.nih.gov/pubmed/16580781
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
Reactome	R-HSA-264876	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-264876
Reactome	R-HSA-435368	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-435368
RefSeq	NP_001180442	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001180442
RefSeq	NP_001180443	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001180443
RefSeq	NP_001180444	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001180444
RefSeq	NP_060434	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060434
TCDB	2.A.4.4	http://www.tcdb.org/search/result.php?tc=2.A.4.4
TIGRFAMs	TIGR01297	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01297
UCSC	uc002roe	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002roe&org=rat
UniGene	Hs.23248	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.23248
UniProtKB	ZNT6_HUMAN	http://www.uniprot.org/uniprot/ZNT6_HUMAN
UniProtKB-AC	Q6NXT4	http://www.uniprot.org/uniprot/Q6NXT4
charge	swissprot:ZNT6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ZNT6_HUMAN
epestfind	swissprot:ZNT6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ZNT6_HUMAN
garnier	swissprot:ZNT6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ZNT6_HUMAN
helixturnhelix	swissprot:ZNT6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZNT6_HUMAN
hmoment	swissprot:ZNT6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ZNT6_HUMAN
iep	swissprot:ZNT6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ZNT6_HUMAN
inforesidue	swissprot:ZNT6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ZNT6_HUMAN
neXtProt	NX_Q6NXT4	http://www.nextprot.org/db/entry/NX_Q6NXT4
octanol	swissprot:ZNT6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ZNT6_HUMAN
pepcoil	swissprot:ZNT6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ZNT6_HUMAN
pepdigest	swissprot:ZNT6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ZNT6_HUMAN
pepinfo	swissprot:ZNT6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ZNT6_HUMAN
pepnet	swissprot:ZNT6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ZNT6_HUMAN
pepstats	swissprot:ZNT6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ZNT6_HUMAN
pepwheel	swissprot:ZNT6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ZNT6_HUMAN
pepwindow	swissprot:ZNT6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ZNT6_HUMAN
sigcleave	swissprot:ZNT6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ZNT6_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AT2B3_HUMAN	Event=Alternative splicing; Named isoforms=8; Comment=There is a combination of two alternatively spliced domains at N-terminal site A (X and Z) and at C-terminal site C (A, B, E and G). The splice sites have mostly been studied independently. Full isoforms so far detected are isoform XA and isoform XB. Experimental confirmation may be lacking for some isoforms.; Name=XB; Synonyms=AIICI; IsoId=Q16720-1; Sequence=Displayed; Name=XA; Synonyms=AIICII; IsoId=Q16720-2; Sequence=VSP_000393; Name=ZA; Synonyms=AICII; IsoId=Q16720-3; Sequence=VSP_000392, VSP_000393; Name=ZB; Synonyms=AICI; IsoId=Q16720-4; Sequence=VSP_000392; Name=XE; Synonyms=AIICV; IsoId=Q16720-5; Sequence=VSP_000394; Name=ZE; Synonyms=AICV; IsoId=Q16720-6; Sequence=VSP_000392, VSP_000394; Name=XG; Synonyms=AIICVII; IsoId=Q16720-7; Sequence=VSP_000395; Name=ZG; Synonyms=AICVII; IsoId=Q16720-8; Sequence=VSP_000392, VSP_000395; 
# AltName	AT2B3_HUMAN	Plasma membrane calcium ATPase isoform 3
# AltName	AT2B3_HUMAN	Plasma membrane calcium pump isoform 3
# BRENDA	3.6.3	2681
# BioGrid	106982	34
# CATALYTIC ACTIVITY	AT2B3_HUMAN	ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2). 
# CCDS	CCDS14722	-. [Q16720-2]
# CCDS	CCDS35440	-. [Q16720-1]
# ChiTaRS	ATP2B3	human
# DISEASE	AT2B3_HUMAN	Spinocerebellar ataxia, X-linked 1 (SCAX1) [MIM 302500]  Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAX1 is characterized by hypotonia at birth, delayed motor development, gait ataxia, difficulty standing, dysarthria, and slow eye movements. Brain MRI shows cerebellar ataxia. {ECO 0000269|PubMed 22912398}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000263519	ENSP00000263519; ENSG00000067842. [Q16720-1]
# Ensembl	ENST00000349466	ENSP00000343886; ENSG00000067842. [Q16720-1]
# Ensembl	ENST00000359149	ENSP00000352062; ENSG00000067842. [Q16720-2]
# Ensembl	ENST00000370186	ENSP00000359205; ENSG00000067842. [Q16720-3]
# Ensembl	ENST00000393842	ENSP00000377425; ENSG00000067842. [Q16720-6]
# FUNCTION	AT2B3_HUMAN	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. 
# GO_component	GO:0005794	Golgi apparatus; IDA:HPA.
# GO_component	GO:0005886	plasma membrane; IDA:HPA.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IBA:GO_Central.
# GO_component	GO:1903561	extracellular vesicle; IDA:UniProtKB.
# GO_function	GO:0005388	calcium-transporting ATPase activity; TAS:Reactome.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0030165	PDZ domain binding; IBA:GO_Central.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006874	cellular calcium ion homeostasis; IBA:GO_Central.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.1110.10	-; 3.
# Genevisible	Q16720	HS
# HGNC	HGNC:816	ATP2B3
# IntAct	Q16720	2
# InterPro	IPR001757	P_typ_ATPase
# InterPro	IPR004014	ATPase_P-typ_cation-transptr_N
# InterPro	IPR006068	ATPase_P-typ_cation-transptr_C
# InterPro	IPR006408	P-type_ATPase_IIB
# InterPro	IPR008250	ATPase_P-typ_transduc_dom_A
# InterPro	IPR018303	ATPase_P-typ_P_site
# InterPro	IPR022141	ATP_Ca_trans_C
# InterPro	IPR023214	HAD-like_dom
# InterPro	IPR023298	ATPase_P-typ_TM_dom
# InterPro	IPR023299	ATPase_P-typ_cyto_domN
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Disease	H01603	[Endocrine disease] Primary aldosteronism
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04970	Salivary secretion
# KEGG_Pathway	ko04972	Pancreatic secretion
# MIM	300014	gene
# MIM	302500	phenotype
# Organism	AT2B3_HUMAN	Homo sapiens (Human)
# Orphanet	314978	X-linked non progressive cerebellar ataxia
# Orphanet	85142	Aldosterone-producing adenoma
# PROSITE	PS00154	ATPASE_E1_E2
# Pfam	PF00122	E1-E2_ATPase; 2
# Pfam	PF00689	Cation_ATPase_C
# Pfam	PF00690	Cation_ATPase_N
# Pfam	PF08282	Hydrolase_3
# Pfam	PF12424	ATP_Ca_trans_C
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-418359	Reduction of cytosolic Ca++ levels
# Reactome	R-HSA-5578775	Ion homeostasis
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	AT2B3_HUMAN	Plasma membrane calcium-transporting ATPase 3
# RefSeq	NP_001001344	NM_001001344.2. [Q16720-1]
# RefSeq	NP_068768	NM_021949.3. [Q16720-2]
# RefSeq	XP_005274747	XM_005274690.3. [Q16720-1]
# RefSeq	XP_005274748	XM_005274691.3. [Q16720-4]
# RefSeq	XP_005274749	XM_005274692.3. [Q16720-2]
# SIMILARITY	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. {ECO	0000305}.
# SMART	SM00831	Cation_ATPase_N
# SUBCELLULAR LOCATION	AT2B3_HUMAN	Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Interacts with PDZD11. {ECO:0000269|PubMed	12763866}. 
# SUPFAM	SSF56784	SSF56784; 2
# SUPFAM	SSF81660	SSF81660
# TIGRFAMs	TIGR01494	ATPase_P-type; 3
# TIGRFAMs	TIGR01517	ATPase-IIB_Ca
# TISSUE SPECIFICITY	Highly expressed in the cerebellum, particulary in the presynaptic terminals of parallel fibers- Purkinje neurons. Isoform XE and isoform XB are the most abundant isoforms and are detected at low levels in brain and fetal skeletal muscle. The other isoforms are only found at lower levels and not in fetal tissues. {ECO:0000269|PubMed	22912398}. 
# UCSC	uc004fhs	human. [Q16720-1]
# eggNOG	ENOG410XNNC	LUCA
# eggNOG	KOG0204	Eukaryota
BLAST	swissprot:AT2B3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AT2B3_HUMAN
BioCyc	ZFISH:HS00921-MONOMER	http://biocyc.org/getid?id=ZFISH:HS00921-MONOMER
COXPRESdb	492	http://coxpresdb.jp/data/gene/492.shtml
CleanEx	HS_ATP2B3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP2B3
DOI	10.1016/0005-2736(96)00108-3	http://dx.doi.org/10.1016/0005-2736(96)00108-3
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1073/pnas.1207488109	http://dx.doi.org/10.1073/pnas.1207488109
DOI	10.1101/gr.10.6.758	http://dx.doi.org/10.1101/gr.10.6.758
DOI	10.1111/j.1749-6632.2003.tb07230.x	http://dx.doi.org/10.1111/j.1749-6632.2003.tb07230.x
EC_number	EC:3.6.3.8	http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.8
EMBL	AH006061	http://www.ebi.ac.uk/ena/data/view/AH006061
EMBL	CH471172	http://www.ebi.ac.uk/ena/data/view/CH471172
EMBL	U15689	http://www.ebi.ac.uk/ena/data/view/U15689
EMBL	U15690	http://www.ebi.ac.uk/ena/data/view/U15690
EMBL	U57971	http://www.ebi.ac.uk/ena/data/view/U57971
EMBL	U60414	http://www.ebi.ac.uk/ena/data/view/U60414
EMBL	U82695	http://www.ebi.ac.uk/ena/data/view/U82695
ENZYME	3.6.3.8	http://enzyme.expasy.org/EC/3.6.3.8
Ensembl	ENST00000263519	http://www.ensembl.org/id/ENST00000263519
Ensembl	ENST00000349466	http://www.ensembl.org/id/ENST00000349466
Ensembl	ENST00000359149	http://www.ensembl.org/id/ENST00000359149
Ensembl	ENST00000370186	http://www.ensembl.org/id/ENST00000370186
Ensembl	ENST00000393842	http://www.ensembl.org/id/ENST00000393842
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_component	GO:1903561	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903561
GO_function	GO:0005388	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005388
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0030165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030165
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.1110.10	http://www.cathdb.info/version/latest/superfamily/1.20.1110.10
GeneCards	ATP2B3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP2B3
GeneID	492	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=492
GeneTree	ENSGT00510000046331	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00510000046331
H-InvDB	HIX0017131	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0017131
HGNC	HGNC:816	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:816
HOGENOM	HOG000265623	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265623&db=HOGENOM6
HOVERGEN	HBG061286	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG061286&db=HOVERGEN
HPA	HPA001583	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA001583
InParanoid	Q16720	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q16720
IntAct	Q16720	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q16720*
IntEnz	3.6.3.8	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.8
InterPro	IPR001757	http://www.ebi.ac.uk/interpro/entry/IPR001757
InterPro	IPR004014	http://www.ebi.ac.uk/interpro/entry/IPR004014
InterPro	IPR006068	http://www.ebi.ac.uk/interpro/entry/IPR006068
InterPro	IPR006408	http://www.ebi.ac.uk/interpro/entry/IPR006408
InterPro	IPR008250	http://www.ebi.ac.uk/interpro/entry/IPR008250
InterPro	IPR018303	http://www.ebi.ac.uk/interpro/entry/IPR018303
InterPro	IPR022141	http://www.ebi.ac.uk/interpro/entry/IPR022141
InterPro	IPR023214	http://www.ebi.ac.uk/interpro/entry/IPR023214
InterPro	IPR023298	http://www.ebi.ac.uk/interpro/entry/IPR023298
InterPro	IPR023299	http://www.ebi.ac.uk/interpro/entry/IPR023299
Jabion	492	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=492
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Disease	H01603	http://www.genome.jp/dbget-bin/www_bget?H01603
KEGG_Gene	hsa:492	http://www.genome.jp/dbget-bin/www_bget?hsa:492
KEGG_Orthology	KO:K05850	http://www.genome.jp/dbget-bin/www_bget?KO:K05850
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04970	http://www.genome.jp/kegg-bin/show_pathway?ko04970
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
MIM	300014	http://www.ncbi.nlm.nih.gov/omim/300014
MIM	302500	http://www.ncbi.nlm.nih.gov/omim/302500
MINT	MINT-2807671	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-2807671
OMA	GNPIFCT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GNPIFCT
Orphanet	314978	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=314978
Orphanet	85142	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=85142
OrthoDB	EOG091G057D	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G057D
PROSITE	PS00154	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00154
PSORT	swissprot:AT2B3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AT2B3_HUMAN
PSORT-B	swissprot:AT2B3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AT2B3_HUMAN
PSORT2	swissprot:AT2B3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AT2B3_HUMAN
Pfam	PF00122	http://pfam.xfam.org/family/PF00122
Pfam	PF00689	http://pfam.xfam.org/family/PF00689
Pfam	PF00690	http://pfam.xfam.org/family/PF00690
Pfam	PF08282	http://pfam.xfam.org/family/PF08282
Pfam	PF12424	http://pfam.xfam.org/family/PF12424
PharmGKB	PA25109	http://www.pharmgkb.org/do/serve?objId=PA25109&objCls=Gene
Phobius	swissprot:AT2B3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AT2B3_HUMAN
PhylomeDB	Q16720	http://phylomedb.org/?seqid=Q16720
ProteinModelPortal	Q16720	http://www.proteinmodelportal.org/query/uniprot/Q16720
PubMed	10854409	http://www.ncbi.nlm.nih.gov/pubmed/10854409
PubMed	12763866	http://www.ncbi.nlm.nih.gov/pubmed/12763866
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	22912398	http://www.ncbi.nlm.nih.gov/pubmed/22912398
PubMed	7989379	http://www.ncbi.nlm.nih.gov/pubmed/7989379
PubMed	8187550	http://www.ncbi.nlm.nih.gov/pubmed/8187550
PubMed	8245032	http://www.ncbi.nlm.nih.gov/pubmed/8245032
PubMed	8765088	http://www.ncbi.nlm.nih.gov/pubmed/8765088
Reactome	R-HSA-418359	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418359
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_001001344	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001001344
RefSeq	NP_068768	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_068768
RefSeq	XP_005274747	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005274747
RefSeq	XP_005274748	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005274748
RefSeq	XP_005274749	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005274749
SMART	SM00831	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00831
STRING	9606.ENSP00000263519	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000263519&targetmode=cogs
SUPFAM	SSF56784	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784
SUPFAM	SSF81660	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81660
TIGRFAMs	TIGR01494	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01494
TIGRFAMs	TIGR01517	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01517
UCSC	uc004fhs	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004fhs&org=rat
UniGene	Hs.533956	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.533956
UniGene	Hs.658008	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.658008
UniProtKB	AT2B3_HUMAN	http://www.uniprot.org/uniprot/AT2B3_HUMAN
UniProtKB-AC	Q16720	http://www.uniprot.org/uniprot/Q16720
charge	swissprot:AT2B3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AT2B3_HUMAN
eggNOG	ENOG410XNNC	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNNC
eggNOG	KOG0204	http://eggnogapi.embl.de/nog_data/html/tree/KOG0204
epestfind	swissprot:AT2B3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AT2B3_HUMAN
garnier	swissprot:AT2B3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AT2B3_HUMAN
helixturnhelix	swissprot:AT2B3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AT2B3_HUMAN
hmoment	swissprot:AT2B3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AT2B3_HUMAN
iep	swissprot:AT2B3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AT2B3_HUMAN
inforesidue	swissprot:AT2B3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AT2B3_HUMAN
neXtProt	NX_Q16720	http://www.nextprot.org/db/entry/NX_Q16720
octanol	swissprot:AT2B3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AT2B3_HUMAN
pepcoil	swissprot:AT2B3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AT2B3_HUMAN
pepdigest	swissprot:AT2B3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AT2B3_HUMAN
pepinfo	swissprot:AT2B3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AT2B3_HUMAN
pepnet	swissprot:AT2B3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AT2B3_HUMAN
pepstats	swissprot:AT2B3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AT2B3_HUMAN
pepwheel	swissprot:AT2B3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AT2B3_HUMAN
pepwindow	swissprot:AT2B3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AT2B3_HUMAN
sigcleave	swissprot:AT2B3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AT2B3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AQP3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q92482-1; Sequence=Displayed; Name=2; Synonyms=delta5; IsoId=Q92482-2; Sequence=VSP_003229, VSP_003230; Note=Due to a polymorphism at the 5'-splice donor site of intron 5, leading to exon 5 skipping and premature termination of translation. This is the molecular basis of the GIL blood group.; 
# AltName	AQP3_HUMAN	Aquaglyceroporin-3
# BioGrid	106856	3
# CCDS	CCDS6542	-. [Q92482-1]
# CDD	cd00333	MIP
# ChiTaRS	AQP3	human
# DOMAIN	AQP3_HUMAN	Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). 
# Ensembl	ENST00000297991	ENSP00000297991; ENSG00000165272. [Q92482-1]
# FUNCTION	AQP3_HUMAN	Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity). {ECO 0000250}. 
# GO_component	GO:0005634	nucleus; IDA:HPA.
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0005911	cell-cell junction; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IC:BHF-UCL.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0005215	transporter activity; NAS:ProtInc.
# GO_function	GO:0015204	urea transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015250	water channel activity; TAS:BHF-UCL.
# GO_function	GO:0015254	glycerol channel activity; IDA:BHF-UCL.
# GO_process	GO:0002684	positive regulation of immune system process; IDA:BHF-UCL.
# GO_process	GO:0003091	renal water homeostasis; TAS:Reactome.
# GO_process	GO:0006810	transport; NAS:ProtInc.
# GO_process	GO:0006833	water transport; TAS:BHF-UCL.
# GO_process	GO:0007588	excretion; TAS:ProtInc.
# GO_process	GO:0009992	cellular water homeostasis; IBA:GO_Central.
# GO_process	GO:0032526	response to retinoic acid; IDA:BHF-UCL.
# GO_process	GO:0033280	response to vitamin D; TAS:BHF-UCL.
# GO_process	GO:0034220	ion transmembrane transport; IBA:GO_Central.
# GO_process	GO:0042476	odontogenesis; IEP:UniProtKB.
# GO_process	GO:0045616	regulation of keratinocyte differentiation; TAS:BHF-UCL.
# GO_process	GO:0051592	response to calcium ion; TAS:BHF-UCL.
# GO_process	GO:0070295	renal water absorption; IEA:Ensembl.
# GO_process	GO:0071918	urea transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.1080.10	-; 1.
# Genevisible	Q92482	HS
# HGNC	HGNC:636	AQP3
# INDUCTION	Up-regulated by magnesium. {ECO:0000269|PubMed	18495115}. 
# IntAct	Q92482	3
# InterPro	IPR000425	MIP
# InterPro	IPR022357	MIP_CS
# InterPro	IPR023271	Aquaporin-like
# InterPro	IPR023275	Aquaporin_3
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04962	Vasopressin-regulated water reabsorption
# MIM	600170	gene
# MIM	607457	phenotype
# Organism	AQP3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR19139	PTHR19139
# PIR	A57119	A57119
# POLYMORPHISM	AQP3_HUMAN	AQP3 is responsible for the GIL blood group system. Isoform 2 is detected in GIL-negative individuals that lack functional AQP3. 
# PRINTS	PR00783	MINTRINSICP
# PRINTS	PR02015	AQUAPORIN3
# PROSITE	PS00221	MIP
# Pfam	PF00230	MIP
# Proteomes	UP000005640	Chromosome 9
# Reactome	R-HSA-432040	Vasopressin regulates renal water homeostasis via Aquaporins
# Reactome	R-HSA-432047	Passive transport by Aquaporins
# RecName	AQP3_HUMAN	Aquaporin-3
# RefSeq	NP_001305073	NM_001318144.1
# RefSeq	NP_004916	NM_004925.4. [Q92482-1]
# SIMILARITY	Belongs to the MIP/aquaporin (TC 1.A.8) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	AQP3_HUMAN	Basolateral cell membrane; Multi-pass membrane protein. Note=In collecting ducts of kidney. 
# SUPFAM	SSF81338	SSF81338
# TIGRFAMs	TIGR00861	MIP
# TISSUE SPECIFICITY	AQP3_HUMAN	Widely expressed in epithelial cells of kidney (collecting ducts) and airways, in keratinocytes, immature dendritic cells and erythrocytes. Isoform 2 is not detectable in erythrocytes at the protein level. 
# UCSC	uc003zsx	human. [Q92482-1]
# WEB RESOURCE	AQP3_HUMAN	Name=SeattleSNPs; URL="http //pga.gs.washington.edu/data/aqp3/";
# WEB RESOURCE	AQP3_HUMAN	Name=dbRBC/BGMUT; Note=Blood group antigen gene mutation database; URL="https //www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=gil"; 
# eggNOG	COG0580	LUCA
# eggNOG	KOG0224	Eukaryota
BLAST	swissprot:AQP3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AQP3_HUMAN
BioCyc	ZFISH:ENSG00000165272-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000165272-MONOMER
COXPRESdb	360	http://coxpresdb.jp/data/gene/360.shtml
CleanEx	HS_AQP3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AQP3
DOI	10.1006/geno.1995.1055	http://dx.doi.org/10.1006/geno.1995.1055
DOI	10.1016/j.ejphar.2008.03.063	http://dx.doi.org/10.1016/j.ejphar.2008.03.063
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M208999200	http://dx.doi.org/10.1074/jbc.M208999200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB001325	http://www.ebi.ac.uk/ena/data/view/AB001325
EMBL	AJ493597	http://www.ebi.ac.uk/ena/data/view/AJ493597
EMBL	AK292208	http://www.ebi.ac.uk/ena/data/view/AK292208
EMBL	AK315760	http://www.ebi.ac.uk/ena/data/view/AK315760
EMBL	AL356218	http://www.ebi.ac.uk/ena/data/view/AL356218
EMBL	BC013566	http://www.ebi.ac.uk/ena/data/view/BC013566
EMBL	BT007199	http://www.ebi.ac.uk/ena/data/view/BT007199
EMBL	CH471071	http://www.ebi.ac.uk/ena/data/view/CH471071
EMBL	CH471071	http://www.ebi.ac.uk/ena/data/view/CH471071
EMBL	CR541991	http://www.ebi.ac.uk/ena/data/view/CR541991
EMBL	CR542025	http://www.ebi.ac.uk/ena/data/view/CR542025
EMBL	DQ083949	http://www.ebi.ac.uk/ena/data/view/DQ083949
Ensembl	ENST00000297991	http://www.ensembl.org/id/ENST00000297991
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005911	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005911
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0015204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015204
GO_function	GO:0015250	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015250
GO_function	GO:0015254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015254
GO_process	GO:0002684	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002684
GO_process	GO:0003091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003091
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006833	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006833
GO_process	GO:0007588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007588
GO_process	GO:0009992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009992
GO_process	GO:0032526	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032526
GO_process	GO:0033280	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033280
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0042476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042476
GO_process	GO:0045616	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045616
GO_process	GO:0051592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051592
GO_process	GO:0070295	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070295
GO_process	GO:0071918	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071918
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.1080.10	http://www.cathdb.info/version/latest/superfamily/1.20.1080.10
GeneCards	AQP3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=AQP3
GeneID	360	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=360
GeneTree	ENSGT00510000046311	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00510000046311
HGNC	HGNC:636	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:636
HOGENOM	HOG000288287	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000288287&db=HOGENOM6
HOVERGEN	HBG106057	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG106057&db=HOVERGEN
HPA	HPA014924	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014924
InParanoid	Q92482	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q92482
IntAct	Q92482	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q92482*
InterPro	IPR000425	http://www.ebi.ac.uk/interpro/entry/IPR000425
InterPro	IPR022357	http://www.ebi.ac.uk/interpro/entry/IPR022357
InterPro	IPR023271	http://www.ebi.ac.uk/interpro/entry/IPR023271
InterPro	IPR023275	http://www.ebi.ac.uk/interpro/entry/IPR023275
Jabion	360	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=360
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:360	http://www.genome.jp/dbget-bin/www_bget?hsa:360
KEGG_Orthology	KO:K09876	http://www.genome.jp/dbget-bin/www_bget?KO:K09876
KEGG_Pathway	ko04962	http://www.genome.jp/kegg-bin/show_pathway?ko04962
MIM	600170	http://www.ncbi.nlm.nih.gov/omim/600170
MIM	607457	http://www.ncbi.nlm.nih.gov/omim/607457
OMA	LDMINGF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LDMINGF
OrthoDB	EOG091G0FMS	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0FMS
PANTHER	PTHR19139	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19139
PRINTS	PR00783	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00783
PRINTS	PR02015	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR02015
PROSITE	PS00221	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00221
PSORT	swissprot:AQP3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AQP3_HUMAN
PSORT-B	swissprot:AQP3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AQP3_HUMAN
PSORT2	swissprot:AQP3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AQP3_HUMAN
Pfam	PF00230	http://pfam.xfam.org/family/PF00230
PharmGKB	PA24921	http://www.pharmgkb.org/do/serve?objId=PA24921&objCls=Gene
Phobius	swissprot:AQP3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AQP3_HUMAN
PhylomeDB	Q92482	http://phylomedb.org/?seqid=Q92482
ProteinModelPortal	Q92482	http://www.proteinmodelportal.org/query/uniprot/Q92482
PubMed	12239222	http://www.ncbi.nlm.nih.gov/pubmed/12239222
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18495115	http://www.ncbi.nlm.nih.gov/pubmed/18495115
PubMed	7558005	http://www.ncbi.nlm.nih.gov/pubmed/7558005
Reactome	R-HSA-432040	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432040
Reactome	R-HSA-432047	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432047
RefSeq	NP_001305073	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001305073
RefSeq	NP_004916	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004916
STRING	9606.ENSP00000297991	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000297991&targetmode=cogs
SUPFAM	SSF81338	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81338
TIGRFAMs	TIGR00861	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00861
UCSC	uc003zsx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003zsx&org=rat
UniGene	Hs.234642	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.234642
UniProtKB	AQP3_HUMAN	http://www.uniprot.org/uniprot/AQP3_HUMAN
UniProtKB-AC	Q92482	http://www.uniprot.org/uniprot/Q92482
charge	swissprot:AQP3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AQP3_HUMAN
eggNOG	COG0580	http://eggnogapi.embl.de/nog_data/html/tree/COG0580
eggNOG	KOG0224	http://eggnogapi.embl.de/nog_data/html/tree/KOG0224
epestfind	swissprot:AQP3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AQP3_HUMAN
garnier	swissprot:AQP3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AQP3_HUMAN
helixturnhelix	swissprot:AQP3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AQP3_HUMAN
hmoment	swissprot:AQP3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AQP3_HUMAN
iep	swissprot:AQP3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AQP3_HUMAN
inforesidue	swissprot:AQP3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AQP3_HUMAN
neXtProt	NX_Q92482	http://www.nextprot.org/db/entry/NX_Q92482
octanol	swissprot:AQP3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AQP3_HUMAN
pepcoil	swissprot:AQP3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AQP3_HUMAN
pepdigest	swissprot:AQP3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AQP3_HUMAN
pepinfo	swissprot:AQP3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AQP3_HUMAN
pepnet	swissprot:AQP3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AQP3_HUMAN
pepstats	swissprot:AQP3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AQP3_HUMAN
pepwheel	swissprot:AQP3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AQP3_HUMAN
pepwindow	swissprot:AQP3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AQP3_HUMAN
sigcleave	swissprot:AQP3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AQP3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GRIK5_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q16478-1; Sequence=Displayed; Name=2; IsoId=Q16478-2; Sequence=VSP_035585; Note=No experimental confirmation available.; 
# AltName	GRIK5_HUMAN	Excitatory amino acid receptor 2
# AltName	GRIK5_HUMAN	Glutamate receptor KA-2
# BioGrid	109158	6
# CCDS	CCDS12595	-. [Q16478-1]
# CCDS	CCDS77305	-. [Q16478-2]
# Ensembl	ENST00000262895	ENSP00000262895; ENSG00000105737. [Q16478-1]
# Ensembl	ENST00000301218	ENSP00000301218; ENSG00000105737. [Q16478-2]
# Ensembl	ENST00000593562	ENSP00000470251; ENSG00000105737. [Q16478-1]
# ExpressionAtlas	Q16478	baseline and differential
# FUNCTION	GRIK5_HUMAN	Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L- glutamate >> AMPA >> NMDA = 1S,3R-ACPD. 
# GO_component	GO:0005783	endoplasmic reticulum; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0014069	postsynaptic density; IEA:Ensembl.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030425	dendrite; IEA:Ensembl.
# GO_component	GO:0032983	kainate selective glutamate receptor complex; IEA:Ensembl.
# GO_component	GO:0042734	presynaptic membrane; IEA:Ensembl.
# GO_component	GO:0043195	terminal bouton; IEA:Ensembl.
# GO_component	GO:0043204	perikaryon; IEA:Ensembl.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0005234	extracellular-glutamate-gated ion channel activity; IEA:InterPro.
# GO_function	GO:0015276	ligand-gated ion channel activity; TAS:Reactome.
# GO_function	GO:0015277	kainate selective glutamate receptor activity; IDA:UniProtKB.
# GO_process	GO:0006621	protein retention in ER lumen; IEA:Ensembl.
# GO_process	GO:0031630	regulation of synaptic vesicle fusion to presynaptic membrane; IEA:Ensembl.
# GO_process	GO:0035249	synaptic transmission, glutamatergic; IEA:Ensembl.
# GO_process	GO:0043113	receptor clustering; IEA:Ensembl.
# GO_process	GO:0043525	positive regulation of neuron apoptotic process; IEA:Ensembl.
# GO_process	GO:0051649	establishment of localization in cell; IEA:Ensembl.
# GO_process	GO:0060079	excitatory postsynaptic potential; IEA:Ensembl.
# GO_process	GO:0071333	cellular response to glucose stimulus; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0061024	membrane organization
# Genevisible	Q16478	HS
# HGNC	HGNC:4583	GRIK5
# IntAct	Q16478	4
# InterPro	IPR001320	Iontro_rcpt
# InterPro	IPR001508	Iono_rcpt_met
# InterPro	IPR001828	ANF_lig-bd_rcpt
# InterPro	IPR019594	Glu/Gly-bd
# InterPro	IPR028082	Peripla_BP_I
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04724	Glutamatergic synapse
# MIM	600283	gene
# Organism	GRIK5_HUMAN	Homo sapiens (Human)
# PIR	I57936	I57936
# PRINTS	PR00177	NMDARECEPTOR
# Pfam	PF00060	Lig_chan
# Pfam	PF01094	ANF_receptor
# Pfam	PF10613	Lig_chan-Glu_bd
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-451308	Activation of Ca-permeable Kainate Receptor
# RecName	GRIK5_HUMAN	Glutamate receptor ionotropic, kainate 5
# RefSeq	NP_001287959	NM_001301030.1. [Q16478-2]
# RefSeq	NP_002079	NM_002088.4. [Q16478-1]
# RefSeq	XP_005258878	XM_005258821.3. [Q16478-1]
# RefSeq	XP_011525165	XM_011526863.2. [Q16478-2]
# SIMILARITY	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK5 subfamily. {ECO	0000305}.
# SMART	SM00079	PBPe
# SMART	SM00918	Lig_chan-Glu_bd
# SUBCELLULAR LOCATION	GRIK5_HUMAN	Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Tetramer of two or more different subunits. Associates with GRIK1 (both edited and unedited versions), GRIK2, or GRIK3 to form functional channels. Homomeric associations do not produce any channel activity (By similarity). {ECO	0000250}. 
# SUPFAM	SSF53822	SSF53822
# UCSC	uc002osj	human. [Q16478-1]
# eggNOG	ENOG410ISR4	Eukaryota
# eggNOG	ENOG410XRUE	LUCA
BLAST	swissprot:GRIK5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GRIK5_HUMAN
BioCyc	ZFISH:ENSG00000105737-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000105737-MONOMER
COXPRESdb	2901	http://coxpresdb.jp/data/gene/2901.shtml
CleanEx	HS_GRIK2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GRIK2
CleanEx	HS_GRIK5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GRIK5
EMBL	AJ249209	http://www.ebi.ac.uk/ena/data/view/AJ249209
EMBL	CH471126	http://www.ebi.ac.uk/ena/data/view/CH471126
EMBL	S40369	http://www.ebi.ac.uk/ena/data/view/S40369
Ensembl	ENST00000262895	http://www.ensembl.org/id/ENST00000262895
Ensembl	ENST00000301218	http://www.ensembl.org/id/ENST00000301218
Ensembl	ENST00000593562	http://www.ensembl.org/id/ENST00000593562
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0014069	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014069
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0032983	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032983
GO_component	GO:0042734	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042734
GO_component	GO:0043195	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043195
GO_component	GO:0043204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043204
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0005234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005234
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_function	GO:0015277	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015277
GO_process	GO:0006621	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006621
GO_process	GO:0031630	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031630
GO_process	GO:0035249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035249
GO_process	GO:0043113	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043113
GO_process	GO:0043525	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043525
GO_process	GO:0051649	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051649
GO_process	GO:0060079	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060079
GO_process	GO:0071333	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071333
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
GeneCards	GRIK5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GRIK5
GeneID	2901	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2901
GeneTree	ENSGT00760000118920	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118920
H-InvDB	HIX0022359	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0022359
H-InvDB	HIX0027521	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0027521
HGNC	HGNC:4583	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4583
HOGENOM	HOG000234371	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234371&db=HOGENOM6
HOVERGEN	HBG051839	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051839&db=HOVERGEN
InParanoid	Q16478	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q16478
IntAct	Q16478	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q16478*
InterPro	IPR001320	http://www.ebi.ac.uk/interpro/entry/IPR001320
InterPro	IPR001508	http://www.ebi.ac.uk/interpro/entry/IPR001508
InterPro	IPR001828	http://www.ebi.ac.uk/interpro/entry/IPR001828
InterPro	IPR019594	http://www.ebi.ac.uk/interpro/entry/IPR019594
InterPro	IPR028082	http://www.ebi.ac.uk/interpro/entry/IPR028082
Jabion	2901	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2901
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:2901	http://www.genome.jp/dbget-bin/www_bget?hsa:2901
KEGG_Orthology	KO:K05205	http://www.genome.jp/dbget-bin/www_bget?KO:K05205
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
MIM	600283	http://www.ncbi.nlm.nih.gov/omim/600283
MINT	MINT-1427286	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1427286
OMA	CTSSNIW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CTSSNIW
OrthoDB	EOG091G02LN	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02LN
PRINTS	PR00177	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00177
PSORT	swissprot:GRIK5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GRIK5_HUMAN
PSORT-B	swissprot:GRIK5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GRIK5_HUMAN
PSORT2	swissprot:GRIK5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GRIK5_HUMAN
Pfam	PF00060	http://pfam.xfam.org/family/PF00060
Pfam	PF01094	http://pfam.xfam.org/family/PF01094
Pfam	PF10613	http://pfam.xfam.org/family/PF10613
PharmGKB	PA28977	http://www.pharmgkb.org/do/serve?objId=PA28977&objCls=Gene
Phobius	swissprot:GRIK5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GRIK5_HUMAN
PhylomeDB	Q16478	http://phylomedb.org/?seqid=Q16478
ProteinModelPortal	Q16478	http://www.proteinmodelportal.org/query/uniprot/Q16478
PubMed	1321949	http://www.ncbi.nlm.nih.gov/pubmed/1321949
Reactome	R-HSA-451308	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-451308
RefSeq	NP_001287959	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001287959
RefSeq	NP_002079	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002079
RefSeq	XP_005258878	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005258878
RefSeq	XP_011525165	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011525165
SMART	SM00079	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00079
SMART	SM00918	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00918
SMR	Q16478	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q16478
STRING	9606.ENSP00000262895	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000262895&targetmode=cogs
SUPFAM	SSF53822	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822
UCSC	uc002osj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002osj&org=rat
UniGene	Hs.367799	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.367799
UniProtKB	GRIK5_HUMAN	http://www.uniprot.org/uniprot/GRIK5_HUMAN
UniProtKB-AC	Q16478	http://www.uniprot.org/uniprot/Q16478
charge	swissprot:GRIK5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GRIK5_HUMAN
eggNOG	ENOG410ISR4	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ISR4
eggNOG	ENOG410XRUE	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRUE
epestfind	swissprot:GRIK5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GRIK5_HUMAN
garnier	swissprot:GRIK5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GRIK5_HUMAN
helixturnhelix	swissprot:GRIK5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GRIK5_HUMAN
hmoment	swissprot:GRIK5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GRIK5_HUMAN
iep	swissprot:GRIK5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GRIK5_HUMAN
inforesidue	swissprot:GRIK5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GRIK5_HUMAN
neXtProt	NX_Q16478	http://www.nextprot.org/db/entry/NX_Q16478
octanol	swissprot:GRIK5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GRIK5_HUMAN
pepcoil	swissprot:GRIK5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GRIK5_HUMAN
pepdigest	swissprot:GRIK5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GRIK5_HUMAN
pepinfo	swissprot:GRIK5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GRIK5_HUMAN
pepnet	swissprot:GRIK5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GRIK5_HUMAN
pepstats	swissprot:GRIK5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GRIK5_HUMAN
pepwheel	swissprot:GRIK5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GRIK5_HUMAN
pepwindow	swissprot:GRIK5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GRIK5_HUMAN
sigcleave	swissprot:GRIK5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GRIK5_HUMAN
## Database	ID	URL or Descriptions
# AltName	ZNT9_HUMAN	Human embryonic lung protein
# AltName	ZNT9_HUMAN	Solute carrier family 30 member 9
# BioGrid	115726	12
# ChiTaRS	SLC30A9	human
# Ensembl	ENST00000264451	ENSP00000264451; ENSG00000014824
# ExpressionAtlas	Q6PML9	baseline and differential
# FUNCTION	ZNT9_HUMAN	Plays a role in the p160 coactivator signaling pathway that mediates transcriptional activation by nuclear receptors. Plays a role in transcriptional activation of Wnt-responsive genes. {ECO 0000250, ECO 0000269|PubMed 10409434}. 
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005856	cytoskeleton; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0003682	chromatin binding; IEA:Ensembl.
# GO_function	GO:0003700	transcription factor activity, sequence-specific DNA binding; NAS:UniProtKB.
# GO_function	GO:0008324	cation transmembrane transporter activity; IEA:InterPro.
# GO_function	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity; IEA:Ensembl.
# GO_process	GO:0006289	nucleotide-excision repair; TAS:BHF-UCL.
# GO_process	GO:0006351	transcription, DNA-templated; IEA:UniProtKB-KW.
# GO_process	GO:0006829	zinc II ion transport; IEA:UniProtKB-KW.
# GO_process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005856	cytoskeleton
# GOslim_function	GO:0000988	transcription factor activity, protein binding
# GOslim_function	GO:0001071	nucleic acid binding transcription factor activity
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006259	DNA metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# Gene3D	1.20.1510.10	-; 1.
# Gene3D	3.90.530.10	-; 1.
# Genevisible	Q6PML9	HS
# HGNC	HGNC:1329	SLC30A9
# IntAct	Q6PML9	5
# InterPro	IPR002524	Cation_efflux
# InterPro	IPR009061	DNA-bd_dom_put
# InterPro	IPR022656	XPA_C
# InterPro	IPR027469	Cation_efflux_TMD
# KEGG_Brite	ko02001	Solute carrier family
# MIM	604604	gene
# Organism	ZNT9_HUMAN	Homo sapiens (Human)
# PDB	2ENK	NMR; -; A=124-217
# Pfam	PF01545	Cation_efflux
# Proteomes	UP000005640	Chromosome 4
# RecName	ZNT9_HUMAN	Zinc transporter 9
# RefSeq	NP_006336	NM_006345.3
# SEQUENCE CAUTION	Sequence=AAP83846.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305}; Sequence=AAY40966.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	ZNT9_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. Nucleus {ECO 0000269|PubMed 10409434}. 
# SUBUNIT	Interacts with GRIP1, ESR1 and AR. {ECO	0000250}. 
# SUPFAM	SSF46955	SSF46955
# TCDB	2.A.4.6	the cation diffusion facilitator (cdf) family
# TIGRFAMs	TIGR01297	CDF
# TISSUE SPECIFICITY	Ubiquitously expressed in fetal and adult tissues and cancer cell lines. {ECO:0000269|PubMed	10409434}. 
# UCSC	uc003gwl	human
# eggNOG	COG0053	LUCA
# eggNOG	KOG2802	Eukaryota
BLAST	swissprot:ZNT9_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ZNT9_HUMAN
COXPRESdb	10463	http://coxpresdb.jp/data/gene/10463.shtml
CleanEx	HS_SLC30A9	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC30A9
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/geno.1999.5856	http://dx.doi.org/10.1006/geno.1999.5856
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC113151	http://www.ebi.ac.uk/ena/data/view/AC113151
EMBL	AF006621	http://www.ebi.ac.uk/ena/data/view/AF006621
EMBL	AY319413	http://www.ebi.ac.uk/ena/data/view/AY319413
EMBL	AY594282	http://www.ebi.ac.uk/ena/data/view/AY594282
EMBL	BC007732	http://www.ebi.ac.uk/ena/data/view/BC007732
EMBL	BC016949	http://www.ebi.ac.uk/ena/data/view/BC016949
EMBL	BC022981	http://www.ebi.ac.uk/ena/data/view/BC022981
Ensembl	ENST00000264451	http://www.ensembl.org/id/ENST00000264451
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0003682	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003682
GO_function	GO:0003700	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700
GO_function	GO:0008324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008324
GO_function	GO:0030374	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030374
GO_process	GO:0006289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006289
GO_process	GO:0006351	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351
GO_process	GO:0006829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006829
GO_process	GO:0045944	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045944
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856
GOslim_function	GO:0000988	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000988
GOslim_function	GO:0001071	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006259	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
Gene3D	1.20.1510.10	http://www.cathdb.info/version/latest/superfamily/1.20.1510.10
Gene3D	3.90.530.10	http://www.cathdb.info/version/latest/superfamily/3.90.530.10
GeneCards	SLC30A9	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC30A9
GeneID	10463	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10463
GeneTree	ENSGT00390000008346	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000008346
H-InvDB	HIX0004181	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0004181
HGNC	HGNC:1329	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1329
HOGENOM	HOG000242618	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000242618&db=HOGENOM6
HOVERGEN	HBG104893	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG104893&db=HOVERGEN
HPA	HPA004014	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA004014
InParanoid	Q6PML9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6PML9
IntAct	Q6PML9	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q6PML9*
InterPro	IPR002524	http://www.ebi.ac.uk/interpro/entry/IPR002524
InterPro	IPR009061	http://www.ebi.ac.uk/interpro/entry/IPR009061
InterPro	IPR022656	http://www.ebi.ac.uk/interpro/entry/IPR022656
InterPro	IPR027469	http://www.ebi.ac.uk/interpro/entry/IPR027469
Jabion	10463	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10463
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:10463	http://www.genome.jp/dbget-bin/www_bget?hsa:10463
KEGG_Orthology	KO:K14696	http://www.genome.jp/dbget-bin/www_bget?KO:K14696
MIM	604604	http://www.ncbi.nlm.nih.gov/omim/604604
OMA	GSHSMFA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GSHSMFA
OrthoDB	EOG091G05KM	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05KM
PDB	2ENK	http://www.ebi.ac.uk/pdbe-srv/view/entry/2ENK
PDBsum	2ENK	http://www.ebi.ac.uk/pdbsum/2ENK
PSORT	swissprot:ZNT9_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ZNT9_HUMAN
PSORT-B	swissprot:ZNT9_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ZNT9_HUMAN
PSORT2	swissprot:ZNT9_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ZNT9_HUMAN
Pfam	PF01545	http://pfam.xfam.org/family/PF01545
PharmGKB	PA25909	http://www.pharmgkb.org/do/serve?objId=PA25909&objCls=Gene
Phobius	swissprot:ZNT9_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ZNT9_HUMAN
PhylomeDB	Q6PML9	http://phylomedb.org/?seqid=Q6PML9
ProteinModelPortal	Q6PML9	http://www.proteinmodelportal.org/query/uniprot/Q6PML9
PubMed	10409434	http://www.ncbi.nlm.nih.gov/pubmed/10409434
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
RefSeq	NP_006336	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006336
SMR	Q6PML9	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q6PML9
STRING	9606.ENSP00000264451	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000264451&targetmode=cogs
SUPFAM	SSF46955	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46955
TCDB	2.A.4.6	http://www.tcdb.org/search/result.php?tc=2.A.4.6
TIGRFAMs	TIGR01297	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01297
UCSC	uc003gwl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003gwl&org=rat
UniGene	Hs.479634	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.479634
UniProtKB	ZNT9_HUMAN	http://www.uniprot.org/uniprot/ZNT9_HUMAN
UniProtKB-AC	Q6PML9	http://www.uniprot.org/uniprot/Q6PML9
charge	swissprot:ZNT9_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ZNT9_HUMAN
eggNOG	COG0053	http://eggnogapi.embl.de/nog_data/html/tree/COG0053
eggNOG	KOG2802	http://eggnogapi.embl.de/nog_data/html/tree/KOG2802
epestfind	swissprot:ZNT9_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ZNT9_HUMAN
garnier	swissprot:ZNT9_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ZNT9_HUMAN
helixturnhelix	swissprot:ZNT9_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZNT9_HUMAN
hmoment	swissprot:ZNT9_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ZNT9_HUMAN
iep	swissprot:ZNT9_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ZNT9_HUMAN
inforesidue	swissprot:ZNT9_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ZNT9_HUMAN
neXtProt	NX_Q6PML9	http://www.nextprot.org/db/entry/NX_Q6PML9
octanol	swissprot:ZNT9_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ZNT9_HUMAN
pepcoil	swissprot:ZNT9_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ZNT9_HUMAN
pepdigest	swissprot:ZNT9_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ZNT9_HUMAN
pepinfo	swissprot:ZNT9_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ZNT9_HUMAN
pepnet	swissprot:ZNT9_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ZNT9_HUMAN
pepstats	swissprot:ZNT9_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ZNT9_HUMAN
pepwheel	swissprot:ZNT9_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ZNT9_HUMAN
pepwindow	swissprot:ZNT9_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ZNT9_HUMAN
sigcleave	swissprot:ZNT9_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ZNT9_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S23A1_HUMAN	Event=Alternative splicing; Named isoforms=3; Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=Q9UHI7-1; Sequence=Displayed; Name=2; IsoId=Q9UHI7-2; Sequence=VSP_006814; Note=Inactive.; Name=3; IsoId=Q9UHI7-3; Sequence=VSP_006813; 
# AltName	S23A1_HUMAN	Na(+)/L-ascorbic acid transporter 1
# AltName	S23A1_HUMAN	Sodium-dependent vitamin C transporter 1
# AltName	S23A1_HUMAN	Yolk sac permease-like molecule 3
# BioGrid	115288	12
# CCDS	CCDS4212	-. [Q9UHI7-1]
# CCDS	CCDS4213	-. [Q9UHI7-2]
# DrugBank	DB00126	Vitamin C
# Ensembl	ENST00000348729	ENSP00000302701; ENSG00000170482
# Ensembl	ENST00000353963	ENSP00000302851; ENSG00000170482
# ExpressionAtlas	Q9UHI7	baseline and differential
# FUNCTION	S23A1_HUMAN	Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate. 
# GO_component	GO:0005737	cytoplasm; ISS:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0009925	basal plasma membrane; IEA:Ensembl.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_component	GO:0043229	intracellular organelle; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0015081	sodium ion transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015205	nucleobase transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0015229	L-ascorbic acid transporter activity; IDA:UniProtKB.
# GO_function	GO:0033300	dehydroascorbic acid transporter activity; IMP:UniProtKB.
# GO_function	GO:0070890	sodium-dependent L-ascorbate transmembrane transporter activity; IDA:UniProtKB.
# GO_function	S23A1_HUMAN	GO 0008520 L-ascorbate sodium symporter activity; IDA UniProtKB.
# GO_process	GO:0006139	nucleobase-containing compound metabolic process; TAS:ProtInc.
# GO_process	GO:0006814	sodium ion transport; IDA:UniProtKB.
# GO_process	GO:0007420	brain development; ISS:UniProtKB.
# GO_process	GO:0009636	response to toxic substance; IDA:UniProtKB.
# GO_process	GO:0015851	nucleobase transport; TAS:ProtInc.
# GO_process	GO:0015882	L-ascorbic acid transport; IDA:UniProtKB.
# GO_process	GO:0019852	L-ascorbic acid metabolic process; TAS:Reactome.
# GO_process	GO:0030324	lung development; IEA:Ensembl.
# GO_process	GO:0070837	dehydroascorbic acid transport; IMP:UniProtKB.
# GO_process	GO:0070904	transepithelial L-ascorbic acid transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0005975	carbohydrate metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0048856	anatomical structure development
# Genevisible	Q9UHI7	HS
# HGNC	HGNC:10974	SLC23A1
# INTERACTION	S23A1_HUMAN	Q6UY14-3 ADAMTSL4; NbExp=3; IntAct=EBI-1759386, EBI-10173507; O43865 AHCYL1; NbExp=3; IntAct=EBI-1759386, EBI-2371423; Q15323 KRT31; NbExp=3; IntAct=EBI-1759386, EBI-948001; P60370 KRTAP10-5; NbExp=3; IntAct=EBI-1759386, EBI-10172150; P60409 KRTAP10-7; NbExp=3; IntAct=EBI-1759386, EBI-10172290; P60410 KRTAP10-8; NbExp=3; IntAct=EBI-1759386, EBI-10171774; P60411 KRTAP10-9; NbExp=3; IntAct=EBI-1759386, EBI-10172052; Q9BYR5 KRTAP4-2; NbExp=3; IntAct=EBI-1759386, EBI-10172511; Q5JR59 MTUS2; NbExp=3; IntAct=EBI-1759386, EBI-742948; P16333 NCK1; NbExp=2; IntAct=EBI-1759386, EBI-389883; Q7Z3S9 NOTCH2NL; NbExp=3; IntAct=EBI-1759386, EBI-945833; 
# IntAct	Q9UHI7	21
# InterPro	IPR006043	Xant/urac/vitC
# InterPro	IPR029954	SLC23A1
# KEGG_Brite	ko02001	Solute carrier family
# MIM	603790	gene
# MISCELLANEOUS	S23A1_HUMAN	Treatment with the protein kinase C stimulator PMA results in a 10-fold decrease in ascorbate accumulation in transfected cells. 
# Organism	S23A1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11119	PTHR11119
# PANTHER	PTHR11119:SF21	PTHR11119:SF21
# PIR	JC7182	JC7182
# PTM	S23A1_HUMAN	Phosphorylated. {ECO 0000305}. 
# Pfam	PF00860	Xan_ur_permease
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-196836	Vitamin C (ascorbate) metabolism
# RecName	S23A1_HUMAN	Solute carrier family 23 member 1
# RefSeq	NP_005838	NM_005847.4
# RefSeq	NP_689898	NM_152685.3
# SIMILARITY	Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	S23A1_HUMAN	Cell membrane {ECO 0000269|PubMed 19379732}; Multi-pass membrane protein {ECO 0000269|PubMed 19379732}. 
# TCDB	2.A.40.6:the nucleobase/ascorbate transporter (nat) or nucleobase	cation symporter-2 (ncs2) family
# TISSUE SPECIFICITY	S23A1_HUMAN	Highly expressed in adult small intestine, kidney, thymus, ovary, colon, prostate and liver, and in fetal kidney, liver and thymus. 
# UCSC	uc003leg	human. [Q9UHI7-1]
# eggNOG	COG2233	LUCA
# eggNOG	KOG1292	Eukaryota
BLAST	swissprot:S23A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S23A1_HUMAN
BioCyc	ZFISH:ENSG00000170482-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000170482-MONOMER
COXPRESdb	9963	http://coxpresdb.jp/data/gene/9963.shtml
CleanEx	HS_SLC23A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC23A1
DOI	10.1006/bbrc.1999.1929	http://dx.doi.org/10.1006/bbrc.1999.1929
DOI	10.1016/S0005-2736(99)00182-0	http://dx.doi.org/10.1016/S0005-2736(99)00182-0
DOI	10.1016/S0014-5793(99)01393-9	http://dx.doi.org/10.1016/S0014-5793(99)01393-9
DOI	10.1016/S0167-4781(98)00151-1	http://dx.doi.org/10.1016/S0167-4781(98)00151-1
DOI	10.1016/j.yexcr.2009.04.007	http://dx.doi.org/10.1016/j.yexcr.2009.04.007
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00126	http://www.drugbank.ca/drugs/DB00126
EMBL	AC135457	http://www.ebi.ac.uk/ena/data/view/AC135457
EMBL	AF058317	http://www.ebi.ac.uk/ena/data/view/AF058317
EMBL	AF098277	http://www.ebi.ac.uk/ena/data/view/AF098277
EMBL	AF170911	http://www.ebi.ac.uk/ena/data/view/AF170911
EMBL	AF375875	http://www.ebi.ac.uk/ena/data/view/AF375875
EMBL	AJ250807	http://www.ebi.ac.uk/ena/data/view/AJ250807
EMBL	AJ269477	http://www.ebi.ac.uk/ena/data/view/AJ269477
EMBL	BC019225	http://www.ebi.ac.uk/ena/data/view/BC019225
EMBL	BC050261	http://www.ebi.ac.uk/ena/data/view/BC050261
Ensembl	ENST00000348729	http://www.ensembl.org/id/ENST00000348729
Ensembl	ENST00000353963	http://www.ensembl.org/id/ENST00000353963
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0009925	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009925
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0043229	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043229
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0008520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008520
GO_function	GO:0015081	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015081
GO_function	GO:0015205	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015205
GO_function	GO:0015229	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015229
GO_function	GO:0033300	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033300
GO_function	GO:0070890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070890
GO_process	GO:0006139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006139
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0007420	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007420
GO_process	GO:0009636	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009636
GO_process	GO:0015851	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015851
GO_process	GO:0015882	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015882
GO_process	GO:0019852	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019852
GO_process	GO:0030324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030324
GO_process	GO:0070837	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070837
GO_process	GO:0070904	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070904
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GeneCards	SLC23A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC23A1
GeneID	9963	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9963
HGNC	HGNC:10974	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10974
HOGENOM	HOG000038201	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000038201&db=HOGENOM6
HOVERGEN	HBG056256	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG056256&db=HOVERGEN
HPA	HPA047612	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA047612
InParanoid	Q9UHI7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UHI7
IntAct	Q9UHI7	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9UHI7*
InterPro	IPR006043	http://www.ebi.ac.uk/interpro/entry/IPR006043
InterPro	IPR029954	http://www.ebi.ac.uk/interpro/entry/IPR029954
Jabion	9963	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9963
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:9963	http://www.genome.jp/dbget-bin/www_bget?hsa:9963
KEGG_Orthology	KO:K14611	http://www.genome.jp/dbget-bin/www_bget?KO:K14611
MIM	603790	http://www.ncbi.nlm.nih.gov/omim/603790
OrthoDB	EOG091G063Y	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G063Y
PANTHER	PTHR11119	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11119
PANTHER	PTHR11119:SF21	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11119:SF21
PSORT	swissprot:S23A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S23A1_HUMAN
PSORT-B	swissprot:S23A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S23A1_HUMAN
PSORT2	swissprot:S23A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S23A1_HUMAN
Pfam	PF00860	http://pfam.xfam.org/family/PF00860
PharmGKB	PA35850	http://www.pharmgkb.org/do/serve?objId=PA35850&objCls=Gene
Phobius	swissprot:S23A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S23A1_HUMAN
PhylomeDB	Q9UHI7	http://phylomedb.org/?seqid=Q9UHI7
ProteinModelPortal	Q9UHI7	http://www.proteinmodelportal.org/query/uniprot/Q9UHI7
PubMed	10556483	http://www.ncbi.nlm.nih.gov/pubmed/10556483
PubMed	10556521	http://www.ncbi.nlm.nih.gov/pubmed/10556521
PubMed	10631088	http://www.ncbi.nlm.nih.gov/pubmed/10631088
PubMed	11396616	http://www.ncbi.nlm.nih.gov/pubmed/11396616
PubMed	11584081	http://www.ncbi.nlm.nih.gov/pubmed/11584081
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19379732	http://www.ncbi.nlm.nih.gov/pubmed/19379732
PubMed	9804989	http://www.ncbi.nlm.nih.gov/pubmed/9804989
Reactome	R-HSA-196836	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-196836
RefSeq	NP_005838	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005838
RefSeq	NP_689898	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_689898
STRING	9606.ENSP00000302851	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000302851&targetmode=cogs
TCDB	2.A.40.6	http://www.tcdb.org/search/result.php?tc=2.A.40.6
UCSC	uc003leg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003leg&org=rat
UniGene	Hs.643467	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.643467
UniProtKB	S23A1_HUMAN	http://www.uniprot.org/uniprot/S23A1_HUMAN
UniProtKB-AC	Q9UHI7	http://www.uniprot.org/uniprot/Q9UHI7
charge	swissprot:S23A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S23A1_HUMAN
eggNOG	COG2233	http://eggnogapi.embl.de/nog_data/html/tree/COG2233
eggNOG	KOG1292	http://eggnogapi.embl.de/nog_data/html/tree/KOG1292
epestfind	swissprot:S23A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S23A1_HUMAN
garnier	swissprot:S23A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S23A1_HUMAN
helixturnhelix	swissprot:S23A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S23A1_HUMAN
hmoment	swissprot:S23A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S23A1_HUMAN
iep	swissprot:S23A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S23A1_HUMAN
inforesidue	swissprot:S23A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S23A1_HUMAN
neXtProt	NX_Q9UHI7	http://www.nextprot.org/db/entry/NX_Q9UHI7
octanol	swissprot:S23A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S23A1_HUMAN
pepcoil	swissprot:S23A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S23A1_HUMAN
pepdigest	swissprot:S23A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S23A1_HUMAN
pepinfo	swissprot:S23A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S23A1_HUMAN
pepnet	swissprot:S23A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S23A1_HUMAN
pepstats	swissprot:S23A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S23A1_HUMAN
pepwheel	swissprot:S23A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S23A1_HUMAN
pepwindow	swissprot:S23A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S23A1_HUMAN
sigcleave	swissprot:S23A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S23A1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	UCP3_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=UCP3L; IsoId=P55916-1; Sequence=Displayed; Name=UCP3S; IsoId=P55916-2; Sequence=VSP_003271; Name=3; IsoId=P55916-3; Sequence=VSP_003270; 
# AltName	UCP3_HUMAN	Solute carrier family 25 member 9
# BioGrid	113199	3
# CCDS	CCDS44677	-. [P55916-2]
# CCDS	CCDS8229	-. [P55916-1]
# DISEASE	UCP3_HUMAN	Obesity (OBESITY) [MIM 601665]  A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. {ECO 0000269|PubMed 9769326, ECO 0000269|Ref.9}. Note=The gene represented in this entry may be involved in disease pathogenesis. 
# Ensembl	ENST00000314032	ENSP00000323740; ENSG00000175564. [P55916-1]
# Ensembl	ENST00000426995	ENSP00000392143; ENSG00000175564. [P55916-2]
# ExpressionAtlas	P55916	baseline and differential
# FUNCTION	UCP3_HUMAN	UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance. 
# GO_component	GO:0005739	mitochondrion; TAS:ProtInc.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005215	transporter activity; TAS:ProtInc.
# GO_function	GO:0017077	oxidative phosphorylation uncoupler activity; IEA:Ensembl.
# GO_process	GO:0000303	response to superoxide; IEA:Ensembl.
# GO_process	GO:0001666	response to hypoxia; IEA:Ensembl.
# GO_process	GO:0006629	lipid metabolic process; TAS:ProtInc.
# GO_process	GO:0006631	fatty acid metabolic process; IEA:Ensembl.
# GO_process	GO:0006839	mitochondrial transport; IEA:InterPro.
# GO_process	GO:0007568	aging; IEA:Ensembl.
# GO_process	GO:0007584	response to nutrient; IEA:Ensembl.
# GO_process	GO:0007585	respiratory gaseous exchange; TAS:ProtInc.
# GO_process	GO:0009409	response to cold; IEA:Ensembl.
# GO_process	GO:0014823	response to activity; IEA:Ensembl.
# GO_process	GO:0015992	proton transport; TAS:Reactome.
# GO_process	GO:0032868	response to insulin; IEA:Ensembl.
# GO_process	GO:0032870	cellular response to hormone stimulus; IEA:Ensembl.
# GO_process	GO:0051384	response to glucocorticoid; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007568	aging
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0044281	small molecule metabolic process
# Gene3D	1.50.40.10	-; 1.
# Genevisible	P55916	HS
# HGNC	HGNC:12519	UCP3
# INTERACTION	UCP3_HUMAN	P03495 NS (xeno); NbExp=2; IntAct=EBI-9116865, EBI-2548993; 
# InterPro	IPR002030	Mit_uncoupling
# InterPro	IPR018108	Mitochondrial_sb/sol_carrier
# InterPro	IPR023395	Mt_carrier_dom
# KEGG_Brite	ko02001	Solute carrier family
# MIM	601665	phenotype
# MIM	602044	gene
# Organism	UCP3_HUMAN	Homo sapiens (Human)
# PIR	JC5522	JC5522
# PRINTS	PR00784	MTUNCOUPLING
# PROSITE	PS50920	SOLCAR; 3
# Pfam	PF00153	Mito_carr; 3
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-167826	The fatty acid cycling model
# Reactome	R-HSA-167827	The proton buffering model
# RecName	UCP3_HUMAN	Mitochondrial uncoupling protein 3
# RefSeq	NP_003347	NM_003356.3. [P55916-1]
# RefSeq	NP_073714	NM_022803.2. [P55916-2]
# SEQUENCE CAUTION	Sequence=AAC51785.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the mitochondrial carrier (TC 2.A.29) family. {ECO	0000305}. 
# SIMILARITY	Contains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule	PRU00282}. 
# SUBCELLULAR LOCATION	UCP3_HUMAN	Mitochondrion inner membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUPFAM	SSF103506	SSF103506
# TCDB	2.A.29.3	the mitochondrial carrier (mc) family
# TISSUE SPECIFICITY	Only in skeletal muscle and heart. Is more expressed in glycolytic than in oxidative skeletal muscles. {ECO:0000269|PubMed	9196039}. 
# UCSC	uc001our	human. [P55916-1]
# eggNOG	ENOG410XRV1	LUCA
# eggNOG	KOG0753	Eukaryota
BLAST	swissprot:UCP3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:UCP3_HUMAN
BioCyc	ZFISH:ENSG00000175564-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000175564-MONOMER
COXPRESdb	7352	http://coxpresdb.jp/data/gene/7352.shtml
CleanEx	HS_UCP3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_UCP3
DOI	10.1006/bbrc.1997.6740	http://dx.doi.org/10.1006/bbrc.1997.6740
DOI	10.1007/s001250050897	http://dx.doi.org/10.1007/s001250050897
DOI	10.1016/S0014-5793(97)00384-0	http://dx.doi.org/10.1016/S0014-5793(97)00384-0
DOI	10.1074/jbc.272.39.24129	http://dx.doi.org/10.1074/jbc.272.39.24129
DOI	10.1074/jbc.272.41.25433	http://dx.doi.org/10.1074/jbc.272.41.25433
DOI	10.1074/jbc.M005713200	http://dx.doi.org/10.1074/jbc.M005713200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1172/JCI4115	http://dx.doi.org/10.1172/JCI4115
EMBL	AF001787	http://www.ebi.ac.uk/ena/data/view/AF001787
EMBL	AF011449	http://www.ebi.ac.uk/ena/data/view/AF011449
EMBL	AF012197	http://www.ebi.ac.uk/ena/data/view/AF012197
EMBL	AF012198	http://www.ebi.ac.uk/ena/data/view/AF012198
EMBL	AF012199	http://www.ebi.ac.uk/ena/data/view/AF012199
EMBL	AF012200	http://www.ebi.ac.uk/ena/data/view/AF012200
EMBL	AF012201	http://www.ebi.ac.uk/ena/data/view/AF012201
EMBL	AF012202	http://www.ebi.ac.uk/ena/data/view/AF012202
EMBL	AF026956	http://www.ebi.ac.uk/ena/data/view/AF026956
EMBL	AF026957	http://www.ebi.ac.uk/ena/data/view/AF026957
EMBL	AF026958	http://www.ebi.ac.uk/ena/data/view/AF026958
EMBL	AF050113	http://www.ebi.ac.uk/ena/data/view/AF050113
EMBL	BC008392	http://www.ebi.ac.uk/ena/data/view/BC008392
EMBL	U82818	http://www.ebi.ac.uk/ena/data/view/U82818
EMBL	U84763	http://www.ebi.ac.uk/ena/data/view/U84763
Ensembl	ENST00000314032	http://www.ensembl.org/id/ENST00000314032
Ensembl	ENST00000426995	http://www.ensembl.org/id/ENST00000426995
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0017077	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017077
GO_process	GO:0000303	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000303
GO_process	GO:0001666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001666
GO_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GO_process	GO:0006631	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006631
GO_process	GO:0006839	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006839
GO_process	GO:0007568	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007568
GO_process	GO:0007584	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007584
GO_process	GO:0007585	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007585
GO_process	GO:0009409	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009409
GO_process	GO:0014823	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014823
GO_process	GO:0015992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992
GO_process	GO:0032868	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032868
GO_process	GO:0032870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032870
GO_process	GO:0051384	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051384
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007568	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007568
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
Gene3D	1.50.40.10	http://www.cathdb.info/version/latest/superfamily/1.50.40.10
GeneCards	UCP3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=UCP3
GeneID	7352	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7352
GeneTree	ENSGT00760000119170	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119170
HGNC	HGNC:12519	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:12519
HOGENOM	HOG000165140	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000165140&db=HOGENOM6
HOVERGEN	HBG009528	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG009528&db=HOVERGEN
HPA	CAB010771	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB010771
InParanoid	P55916	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P55916
IntAct	P55916	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P55916*
InterPro	IPR002030	http://www.ebi.ac.uk/interpro/entry/IPR002030
InterPro	IPR018108	http://www.ebi.ac.uk/interpro/entry/IPR018108
InterPro	IPR023395	http://www.ebi.ac.uk/interpro/entry/IPR023395
Jabion	7352	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7352
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:7352	http://www.genome.jp/dbget-bin/www_bget?hsa:7352
KEGG_Orthology	KO:K15103	http://www.genome.jp/dbget-bin/www_bget?KO:K15103
MIM	601665	http://www.ncbi.nlm.nih.gov/omim/601665
MIM	602044	http://www.ncbi.nlm.nih.gov/omim/602044
OMA	KGTWPNI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KGTWPNI
OrthoDB	EOG091G0BQ7	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0BQ7
PRINTS	PR00784	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00784
PROSITE	PS50920	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50920
PSORT	swissprot:UCP3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:UCP3_HUMAN
PSORT-B	swissprot:UCP3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:UCP3_HUMAN
PSORT2	swissprot:UCP3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:UCP3_HUMAN
Pfam	PF00153	http://pfam.xfam.org/family/PF00153
PharmGKB	PA37166	http://www.pharmgkb.org/do/serve?objId=PA37166&objCls=Gene
Phobius	swissprot:UCP3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:UCP3_HUMAN
PhylomeDB	P55916	http://phylomedb.org/?seqid=P55916
ProteinModelPortal	P55916	http://www.proteinmodelportal.org/query/uniprot/P55916
PubMed	10958796	http://www.ncbi.nlm.nih.gov/pubmed/10958796
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	9180264	http://www.ncbi.nlm.nih.gov/pubmed/9180264
PubMed	9196039	http://www.ncbi.nlm.nih.gov/pubmed/9196039
PubMed	9305858	http://www.ncbi.nlm.nih.gov/pubmed/9305858
PubMed	9325252	http://www.ncbi.nlm.nih.gov/pubmed/9325252
PubMed	9498661	http://www.ncbi.nlm.nih.gov/pubmed/9498661
PubMed	9769326	http://www.ncbi.nlm.nih.gov/pubmed/9769326
Reactome	R-HSA-167826	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-167826
Reactome	R-HSA-167827	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-167827
RefSeq	NP_003347	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003347
RefSeq	NP_073714	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_073714
STRING	9606.ENSP00000323740	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000323740&targetmode=cogs
SUPFAM	SSF103506	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103506
TCDB	2.A.29.3	http://www.tcdb.org/search/result.php?tc=2.A.29.3
UCSC	uc001our	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001our&org=rat
UniGene	Hs.101337	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.101337
UniGene	Hs.621879	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.621879
UniProtKB	UCP3_HUMAN	http://www.uniprot.org/uniprot/UCP3_HUMAN
UniProtKB-AC	P55916	http://www.uniprot.org/uniprot/P55916
charge	swissprot:UCP3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:UCP3_HUMAN
eggNOG	ENOG410XRV1	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRV1
eggNOG	KOG0753	http://eggnogapi.embl.de/nog_data/html/tree/KOG0753
epestfind	swissprot:UCP3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:UCP3_HUMAN
garnier	swissprot:UCP3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:UCP3_HUMAN
helixturnhelix	swissprot:UCP3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:UCP3_HUMAN
hmoment	swissprot:UCP3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:UCP3_HUMAN
iep	swissprot:UCP3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:UCP3_HUMAN
inforesidue	swissprot:UCP3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:UCP3_HUMAN
neXtProt	NX_P55916	http://www.nextprot.org/db/entry/NX_P55916
octanol	swissprot:UCP3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:UCP3_HUMAN
pepcoil	swissprot:UCP3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:UCP3_HUMAN
pepdigest	swissprot:UCP3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:UCP3_HUMAN
pepinfo	swissprot:UCP3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:UCP3_HUMAN
pepnet	swissprot:UCP3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:UCP3_HUMAN
pepstats	swissprot:UCP3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:UCP3_HUMAN
pepwheel	swissprot:UCP3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:UCP3_HUMAN
pepwindow	swissprot:UCP3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:UCP3_HUMAN
sigcleave	swissprot:UCP3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:UCP3_HUMAN
## Database	ID	URL or Descriptions
# AltName	SO2A1_HUMAN	Prostaglandin transporter
# AltName	SO2A1_HUMAN	Solute carrier family 21 member 2
# CDD	cd06174	MFS
# ChiTaRS	SLCO2A1	human
# DISEASE	SO2A1_HUMAN	Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2) [MIM 614441]  A disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease. {ECO 0000269|PubMed 22197487, ECO 0000269|PubMed 22331663, ECO 0000269|PubMed 22553128, ECO 0000269|PubMed 22696055}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00119	Pyruvic acid
# DrugBank	DB00695	Furosemide
# DrugBank	DB00770	Alprostadil
# DrugBank	DB00917	Dinoprostone
# DrugBank	DB01088	Iloprost
# DrugBank	DB01160	Dinoprost Tromethamine
# DrugBank	DB01174	Phenobarbital
# DrugBank	DB04398	Lactic Acid
# Ensembl	ENST00000310926	ENSP00000311291; ENSG00000174640
# ExpressionAtlas	Q92959	baseline and differential
# FUNCTION	SO2A1_HUMAN	May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_function	GO:0005319	lipid transporter activity; TAS:ProtInc.
# GO_function	GO:0015132	prostaglandin transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015347	sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0006869	lipid transport; TAS:ProtInc.
# GO_process	GO:0043252	sodium-independent organic anion transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q92959	HS
# HGNC	HGNC:10955	SLCO2A1
# InterPro	IPR002350	Kazal_dom
# InterPro	IPR004156	OA_transporter
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02001	Solute carrier family
# MIM	601460	gene
# MIM	614441	phenotype
# Organism	SO2A1_HUMAN	Homo sapiens (Human)
# Orphanet	2796	Pachydermoperiostosis
# PANTHER	PTHR11388	PTHR11388
# PDB	3MRR	X-ray; 1.60 A; P=178-187
# PROSITE	PS50850	MFS
# PROSITE	PS51465	KAZAL_2
# Pfam	PF03137	OATP
# Pfam	PF07648	Kazal_2
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-879518	Transport of organic anions
# RecName	SO2A1_HUMAN	Solute carrier organic anion transporter family member 2A1
# RefSeq	NP_005621	NM_005630.2
# SIMILARITY	Belongs to the organo anion transporter (TC 2.A.60) family. {ECO	0000305}. 
# SIMILARITY	Contains 1 Kazal-like domain. {ECO:0000255|PROSITE- ProRule	PRU00798}. 
# SUBCELLULAR LOCATION	SO2A1_HUMAN	Cell membrane; Multi-pass membrane protein. 
# SUPFAM	SSF103473	SSF103473; 4
# TCDB	2.A.60.1.19	the organo anion transporter (oat) family
# TIGRFAMs	TIGR00805	oat
# TISSUE SPECIFICITY	Ubiquitous. Significant expression observed in ling, kidney, spleen, and heart. {ECO:0000269|PubMed	22331663}. 
# UCSC	uc003eqa	human
# WEB RESOURCE	SO2A1_HUMAN	Name=Solute carrier organic anion transporter family, member 2A1 (SLCO2A1); Note=Leiden Open Variation Database (LOVD); URL="http //www.lovd.nl/SLCO2A1";
# eggNOG	ENOG410XRSF	LUCA
# eggNOG	KOG3626	Eukaryota
BLAST	swissprot:SO2A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SO2A1_HUMAN
BioCyc	ZFISH:ENSG00000174640-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000174640-MONOMER
COXPRESdb	6578	http://coxpresdb.jp/data/gene/6578.shtml
CleanEx	HS_SLCO2A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLCO2A1
DOI	10.1002/humu.22042	http://dx.doi.org/10.1002/humu.22042
DOI	10.1002/humu.22111	http://dx.doi.org/10.1002/humu.22111
DOI	10.1006/bbrc.1998.8715	http://dx.doi.org/10.1006/bbrc.1998.8715
DOI	10.1016/j.ajhg.2011.11.019	http://dx.doi.org/10.1016/j.ajhg.2011.11.019
DOI	10.1038/jid.2012.146	http://dx.doi.org/10.1038/jid.2012.146
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1172/JCI118897	http://dx.doi.org/10.1172/JCI118897
DrugBank	DB00119	http://www.drugbank.ca/drugs/DB00119
DrugBank	DB00695	http://www.drugbank.ca/drugs/DB00695
DrugBank	DB00770	http://www.drugbank.ca/drugs/DB00770
DrugBank	DB00917	http://www.drugbank.ca/drugs/DB00917
DrugBank	DB01088	http://www.drugbank.ca/drugs/DB01088
DrugBank	DB01160	http://www.drugbank.ca/drugs/DB01160
DrugBank	DB01174	http://www.drugbank.ca/drugs/DB01174
DrugBank	DB04398	http://www.drugbank.ca/drugs/DB04398
EMBL	AF056719	http://www.ebi.ac.uk/ena/data/view/AF056719
EMBL	AF056720	http://www.ebi.ac.uk/ena/data/view/AF056720
EMBL	AF056721	http://www.ebi.ac.uk/ena/data/view/AF056721
EMBL	AF056722	http://www.ebi.ac.uk/ena/data/view/AF056722
EMBL	AF056723	http://www.ebi.ac.uk/ena/data/view/AF056723
EMBL	AF056724	http://www.ebi.ac.uk/ena/data/view/AF056724
EMBL	AF056725	http://www.ebi.ac.uk/ena/data/view/AF056725
EMBL	AF056726	http://www.ebi.ac.uk/ena/data/view/AF056726
EMBL	AF056727	http://www.ebi.ac.uk/ena/data/view/AF056727
EMBL	AF056728	http://www.ebi.ac.uk/ena/data/view/AF056728
EMBL	AF056729	http://www.ebi.ac.uk/ena/data/view/AF056729
EMBL	AF056730	http://www.ebi.ac.uk/ena/data/view/AF056730
EMBL	AF056731	http://www.ebi.ac.uk/ena/data/view/AF056731
EMBL	AF056732	http://www.ebi.ac.uk/ena/data/view/AF056732
EMBL	BC041140	http://www.ebi.ac.uk/ena/data/view/BC041140
EMBL	BC051347	http://www.ebi.ac.uk/ena/data/view/BC051347
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
EMBL	U70867	http://www.ebi.ac.uk/ena/data/view/U70867
Ensembl	ENST00000310926	http://www.ensembl.org/id/ENST00000310926
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0005319	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005319
GO_function	GO:0015132	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015132
GO_function	GO:0015347	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015347
GO_process	GO:0006869	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006869
GO_process	GO:0043252	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043252
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLCO2A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLCO2A1
GeneID	6578	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6578
GeneTree	ENSGT00760000119014	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119014
H-InvDB	HIX0024333	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0024333
HGNC	HGNC:10955	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10955
HOGENOM	HOG000231269	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231269&db=HOGENOM6
HOVERGEN	HBG108345	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108345&db=HOVERGEN
HPA	HPA013742	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA013742
InParanoid	Q92959	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q92959
IntAct	Q92959	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q92959*
InterPro	IPR002350	http://www.ebi.ac.uk/interpro/entry/IPR002350
InterPro	IPR004156	http://www.ebi.ac.uk/interpro/entry/IPR004156
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	6578	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6578
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6578	http://www.genome.jp/dbget-bin/www_bget?hsa:6578
KEGG_Orthology	KO:K14345	http://www.genome.jp/dbget-bin/www_bget?KO:K14345
MIM	601460	http://www.ncbi.nlm.nih.gov/omim/601460
MIM	614441	http://www.ncbi.nlm.nih.gov/omim/614441
OMA	IYLNCSC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IYLNCSC
Orphanet	2796	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=2796
OrthoDB	EOG091G08QD	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08QD
PANTHER	PTHR11388	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11388
PDB	3MRR	http://www.ebi.ac.uk/pdbe-srv/view/entry/3MRR
PDBsum	3MRR	http://www.ebi.ac.uk/pdbsum/3MRR
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PROSITE	PS51465	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51465
PSORT	swissprot:SO2A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SO2A1_HUMAN
PSORT-B	swissprot:SO2A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SO2A1_HUMAN
PSORT2	swissprot:SO2A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SO2A1_HUMAN
Pfam	PF03137	http://pfam.xfam.org/family/PF03137
Pfam	PF07648	http://pfam.xfam.org/family/PF07648
PharmGKB	PA35840	http://www.pharmgkb.org/do/serve?objId=PA35840&objCls=Gene
Phobius	swissprot:SO2A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SO2A1_HUMAN
PhylomeDB	Q92959	http://phylomedb.org/?seqid=Q92959
ProteinModelPortal	Q92959	http://www.proteinmodelportal.org/query/uniprot/Q92959
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	22197487	http://www.ncbi.nlm.nih.gov/pubmed/22197487
PubMed	22331663	http://www.ncbi.nlm.nih.gov/pubmed/22331663
PubMed	22553128	http://www.ncbi.nlm.nih.gov/pubmed/22553128
PubMed	22696055	http://www.ncbi.nlm.nih.gov/pubmed/22696055
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	8787677	http://www.ncbi.nlm.nih.gov/pubmed/8787677
PubMed	9618293	http://www.ncbi.nlm.nih.gov/pubmed/9618293
Reactome	R-HSA-879518	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-879518
RefSeq	NP_005621	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005621
SMR	Q92959	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q92959
STRING	9606.ENSP00000311291	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000311291&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.60.1.19	http://www.tcdb.org/search/result.php?tc=2.A.60.1.19
TIGRFAMs	TIGR00805	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00805
UCSC	uc003eqa	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003eqa&org=rat
UniGene	Hs.518270	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.518270
UniProtKB	SO2A1_HUMAN	http://www.uniprot.org/uniprot/SO2A1_HUMAN
UniProtKB-AC	Q92959	http://www.uniprot.org/uniprot/Q92959
charge	swissprot:SO2A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SO2A1_HUMAN
eggNOG	ENOG410XRSF	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRSF
eggNOG	KOG3626	http://eggnogapi.embl.de/nog_data/html/tree/KOG3626
epestfind	swissprot:SO2A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SO2A1_HUMAN
garnier	swissprot:SO2A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SO2A1_HUMAN
helixturnhelix	swissprot:SO2A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SO2A1_HUMAN
hmoment	swissprot:SO2A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SO2A1_HUMAN
iep	swissprot:SO2A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SO2A1_HUMAN
inforesidue	swissprot:SO2A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SO2A1_HUMAN
neXtProt	NX_Q92959	http://www.nextprot.org/db/entry/NX_Q92959
octanol	swissprot:SO2A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SO2A1_HUMAN
pepcoil	swissprot:SO2A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SO2A1_HUMAN
pepdigest	swissprot:SO2A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SO2A1_HUMAN
pepinfo	swissprot:SO2A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SO2A1_HUMAN
pepnet	swissprot:SO2A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SO2A1_HUMAN
pepstats	swissprot:SO2A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SO2A1_HUMAN
pepwheel	swissprot:SO2A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SO2A1_HUMAN
pepwindow	swissprot:SO2A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SO2A1_HUMAN
sigcleave	swissprot:SO2A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SO2A1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	OAZ3_HUMAN	Event=Ribosomal frameshifting, Alternative splicing; Named isoforms=2; Comment=A ribosomal frameshift occurs between the codons for Ser-76 and Glu-77. An autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines.; Name=1; IsoId=Q9UMX2-1; Sequence=Displayed; Name=2; IsoId=Q9UMX2-2; Sequence=VSP_056789, VSP_056790, VSP_056791; Note=No experimental confirmation available.; 
# BioGrid	119677	30
# CCDS	CCDS58028	-. [Q9UMX2-2]
# CCDS	CCDS81378	-. [Q9UMX2-1]
# DEVELOPMENTAL STAGE	OAZ3_HUMAN	Expression starts early in spermiogenesis and finishes in the late spermatid phase. 
# DrugBank	DB00129	L-Ornithine
# Ensembl	ENST00000627780	ENSP00000486158; ENSG00000143450. [Q9UMX2-2]
# ExpressionAtlas	Q9UMX2	baseline and differential
# FUNCTION	OAZ3_HUMAN	Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to ODC1 without promoting its degradation (PubMed 17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells. {ECO 0000269|PubMed 17900240}. 
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005737	cytoplasm; IBA:GO_Central.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0072562	blood microparticle; IDA:UniProtKB.
# GO_function	GO:0008073	ornithine decarboxylase inhibitor activity; IDA:UniProtKB.
# GO_function	GO:0015489	putrescine transmembrane transporter activity; ISS:UniProtKB.
# GO_process	GO:0006521	regulation of cellular amino acid metabolic process; TAS:Reactome.
# GO_process	GO:0006595	polyamine metabolic process; IBA:GO_Central.
# GO_process	GO:0006596	polyamine biosynthetic process; IEA:UniProtKB-KW.
# GO_process	GO:0007283	spermatogenesis; TAS:ProtInc.
# GO_process	GO:0045732	positive regulation of protein catabolic process; ISS:UniProtKB.
# GO_process	GO:1902268	negative regulation of polyamine transmembrane transport; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0030234	enzyme regulator activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# Genevisible	Q9UMX2	HS
# HGNC	HGNC:8097	OAZ3
# INTERACTION	OAZ3_HUMAN	O14977 AZIN1; NbExp=3; IntAct=EBI-10281601, EBI-1054824; Q96A70 AZIN2; NbExp=5; IntAct=EBI-10281601, EBI-10281609; Q9H2G9 BLZF1; NbExp=3; IntAct=EBI-10281601, EBI-2548012; Q6P1W5 C1orf94; NbExp=3; IntAct=EBI-10281601, EBI-946029; Q9UKT9 IKZF3; NbExp=3; IntAct=EBI-10281601, EBI-747204; Q96JM7 L3MBTL3; NbExp=3; IntAct=EBI-10281601, EBI-2686809; P11926 ODC1; NbExp=4; IntAct=EBI-12049527, EBI-1044287; Q04864 REL; NbExp=3; IntAct=EBI-10281601, EBI-307352; 
# IntAct	Q9UMX2	10
# InterPro	IPR002993	ODC_AZ
# InterPro	IPR016181	Acyl_CoA_acyltransferase
# InterPro	IPR029913	ODC-AZ_3
# MIM	605138	gene
# Organism	OAZ3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10279	PTHR10279
# PANTHER	PTHR10279:SF9	PTHR10279:SF9
# PROSITE	PS01337	ODC_AZ
# Pfam	PF02100	ODC_AZ
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-350562	Regulation of ornithine decarboxylase (ODC)
# RecName	OAZ3_HUMAN	Ornithine decarboxylase antizyme 3
# RefSeq	NP_001128411	NM_001134939.1
# RefSeq	NP_001288300	NM_001301371.1
# RefSeq	NP_057262	NM_016178.2. [Q9UMX2-1]
# SEQUENCE CAUTION	Sequence=AAD51734.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD51734.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the ODC antizyme family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	OAZ3_HUMAN	Nucleus. Cytoplasm {ECO 0000250}. 
# SUBUNIT	Interacts with GGN (By similarity). Interacts with AZIN2; the interaction stabilizes the complex by inhibiting AZIN2 ubiquitination and degradation and leads to increased ornithine decarboxylase (ODC) activity and decreased rate of ODC1 degradation. {ECO:0000250, ECO	0000269|PubMed:17900240}. 
# SUPFAM	SSF55729	SSF55729
# TISSUE SPECIFICITY	OAZ3_HUMAN	Testis specific. 
# UCSC	uc010pdl	human. [Q9UMX2-1]
# eggNOG	ENOG4112791	LUCA
# eggNOG	KOG4387	Eukaryota
BLAST	swissprot:OAZ3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:OAZ3_HUMAN
BioCyc	ZFISH:ENSG00000143450-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000143450-MONOMER
COXPRESdb	51686	http://coxpresdb.jp/data/gene/51686.shtml
CleanEx	HS_OAZ3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_OAZ3
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1042/BJ20071004	http://dx.doi.org/10.1042/BJ20071004
DOI	10.1073/pnas.070055897	http://dx.doi.org/10.1073/pnas.070055897
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00129	http://www.drugbank.ca/drugs/DB00129
EMBL	AF175296	http://www.ebi.ac.uk/ena/data/view/AF175296
EMBL	AL589765	http://www.ebi.ac.uk/ena/data/view/AL589765
EMBL	BC073949	http://www.ebi.ac.uk/ena/data/view/BC073949
Ensembl	ENST00000627780	http://www.ensembl.org/id/ENST00000627780
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0072562	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072562
GO_function	GO:0008073	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008073
GO_function	GO:0015489	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015489
GO_process	GO:0006521	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006521
GO_process	GO:0006595	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006595
GO_process	GO:0006596	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006596
GO_process	GO:0007283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007283
GO_process	GO:0045732	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045732
GO_process	GO:1902268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902268
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0030234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GeneCards	OAZ3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=OAZ3
GeneID	51686	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51686
GeneTree	ENSGT00390000009476	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000009476
HGNC	HGNC:8097	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:8097
HOGENOM	HOG000115254	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000115254&db=HOGENOM6
HOVERGEN	HBG101008	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG101008&db=HOVERGEN
InParanoid	Q9UMX2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UMX2
IntAct	Q9UMX2	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9UMX2*
InterPro	IPR002993	http://www.ebi.ac.uk/interpro/entry/IPR002993
InterPro	IPR016181	http://www.ebi.ac.uk/interpro/entry/IPR016181
InterPro	IPR029913	http://www.ebi.ac.uk/interpro/entry/IPR029913
Jabion	51686	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=51686
KEGG_Gene	hsa:51686	http://www.genome.jp/dbget-bin/www_bget?hsa:51686
KEGG_Orthology	KO:K16614	http://www.genome.jp/dbget-bin/www_bget?KO:K16614
MIM	605138	http://www.ncbi.nlm.nih.gov/omim/605138
PANTHER	PTHR10279	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10279
PANTHER	PTHR10279:SF9	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10279:SF9
PROSITE	PS01337	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01337
PSORT	swissprot:OAZ3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:OAZ3_HUMAN
PSORT-B	swissprot:OAZ3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:OAZ3_HUMAN
PSORT2	swissprot:OAZ3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:OAZ3_HUMAN
Pfam	PF02100	http://pfam.xfam.org/family/PF02100
PharmGKB	PA31886	http://www.pharmgkb.org/do/serve?objId=PA31886&objCls=Gene
Phobius	swissprot:OAZ3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:OAZ3_HUMAN
ProteinModelPortal	Q9UMX2	http://www.proteinmodelportal.org/query/uniprot/Q9UMX2
PubMed	10781085	http://www.ncbi.nlm.nih.gov/pubmed/10781085
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17900240	http://www.ncbi.nlm.nih.gov/pubmed/17900240
Reactome	R-HSA-350562	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-350562
RefSeq	NP_001128411	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001128411
RefSeq	NP_001288300	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001288300
RefSeq	NP_057262	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_057262
SMR	Q9UMX2	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9UMX2
STRING	9606.ENSP00000415904	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000415904&targetmode=cogs
SUPFAM	SSF55729	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55729
UCSC	uc010pdl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010pdl&org=rat
UniGene	Hs.713789	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.713789
UniProtKB	OAZ3_HUMAN	http://www.uniprot.org/uniprot/OAZ3_HUMAN
UniProtKB-AC	Q9UMX2	http://www.uniprot.org/uniprot/Q9UMX2
charge	swissprot:OAZ3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:OAZ3_HUMAN
eggNOG	ENOG4112791	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4112791
eggNOG	KOG4387	http://eggnogapi.embl.de/nog_data/html/tree/KOG4387
epestfind	swissprot:OAZ3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:OAZ3_HUMAN
garnier	swissprot:OAZ3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:OAZ3_HUMAN
helixturnhelix	swissprot:OAZ3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:OAZ3_HUMAN
hmoment	swissprot:OAZ3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:OAZ3_HUMAN
iep	swissprot:OAZ3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:OAZ3_HUMAN
inforesidue	swissprot:OAZ3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:OAZ3_HUMAN
neXtProt	NX_Q9UMX2	http://www.nextprot.org/db/entry/NX_Q9UMX2
octanol	swissprot:OAZ3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:OAZ3_HUMAN
pepcoil	swissprot:OAZ3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:OAZ3_HUMAN
pepdigest	swissprot:OAZ3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:OAZ3_HUMAN
pepinfo	swissprot:OAZ3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:OAZ3_HUMAN
pepnet	swissprot:OAZ3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:OAZ3_HUMAN
pepstats	swissprot:OAZ3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:OAZ3_HUMAN
pepwheel	swissprot:OAZ3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:OAZ3_HUMAN
pepwindow	swissprot:OAZ3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:OAZ3_HUMAN
sigcleave	swissprot:OAZ3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:OAZ3_HUMAN
## Database	ID	URL or Descriptions
# Ensembl	ENST00000286808	ENSP00000286808; ENSG00000156282
# FUNCTION	CLD17_HUMAN	Channel-forming tight junction protein with selectivity for anions, including chloride and bicarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tubule, may be involved in quantitative reabsorption of filtered anions. Does not affect water permeability. {ECO 0000269|PubMed 22402829}. 
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005923	bicellular tight junction; ISS:UniProtKB.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_function	GO:0005198	structural molecule activity; IEA:InterPro.
# GO_function	GO:0005254	chloride channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0042802	identical protein binding; ISS:UniProtKB.
# GO_process	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0005198	structural molecule activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0007155	cell adhesion
# Genevisible	P56750	HS
# HGNC	HGNC:2038	CLDN17
# InterPro	IPR004031	PMP22/EMP/MP20/Claudin
# InterPro	IPR006187	Claudin
# InterPro	IPR017974	Claudin_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04516	 Cell adhesion molecules and their ligands
# KEGG_Pathway	ko04514	Cell adhesion molecules (CAMs)
# KEGG_Pathway	ko04530	Tight junction
# KEGG_Pathway	ko04670	Leukocyte transendothelial migration
# KEGG_Pathway	ko05160	Hepatitis C
# MIM	617005	gene
# Organism	CLD17_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12002	PTHR12002
# PROSITE	PS01346	CLAUDIN
# Pfam	PF00822	PMP22_Claudin
# Proteomes	UP000005640	Chromosome 21
# Reactome	R-HSA-420029	Tight junction interactions
# RecName	CLD17_HUMAN	Claudin-17
# RefSeq	NP_036263	NM_012131.2
# SEQUENCE CAUTION	Sequence=AAQ88461.1; Type=Frameshift; Positions=31; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the claudin family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	CLD17_HUMAN	Cell junction, tight junction {ECO 0000269|PubMed 22402829}. Cell membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000255}. 
# TCDB	1.H.1.1.13	the claudin tight junction (claudin1) family
# TISSUE SPECIFICITY	In the kidney, expressed in the proximal tubule and in the Henle's loop. In the distal convoluted tubule, not expressed in all tubules. Not detected in the collecting duct (at protein level). {ECO:0000269|PubMed	22402829}. 
# UCSC	uc011acv	human
# eggNOG	ENOG410IJK4	Eukaryota
# eggNOG	ENOG410YQQY	LUCA
BLAST	swissprot:CLD17_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CLD17_HUMAN
BioCyc	ZFISH:ENSG00000156282-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000156282-MONOMER
COXPRESdb	26285	http://coxpresdb.jp/data/gene/26285.shtml
CleanEx	HS_CLDN17	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CLDN17
DOI	10.1007/s00018-012-0949-x	http://dx.doi.org/10.1007/s00018-012-0949-x
DOI	10.1007/s00018-015-1987-y	http://dx.doi.org/10.1007/s00018-015-1987-y
DOI	10.1038/35012518	http://dx.doi.org/10.1038/35012518
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AJ250712	http://www.ebi.ac.uk/ena/data/view/AJ250712
EMBL	AP001707	http://www.ebi.ac.uk/ena/data/view/AP001707
EMBL	AY358094	http://www.ebi.ac.uk/ena/data/view/AY358094
EMBL	BC101503	http://www.ebi.ac.uk/ena/data/view/BC101503
EMBL	BC101505	http://www.ebi.ac.uk/ena/data/view/BC101505
Ensembl	ENST00000286808	http://www.ensembl.org/id/ENST00000286808
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005923	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005923
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_function	GO:0005198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0042802	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802
GO_process	GO:0016338	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016338
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0005198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GeneCards	CLDN17	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CLDN17
GeneID	26285	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26285
GeneTree	ENSGT00760000118928	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118928
HGNC	HGNC:2038	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2038
HOGENOM	HOG000220937	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220937&db=HOGENOM6
HOVERGEN	HBG000643	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000643&db=HOVERGEN
HPA	HPA045903	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA045903
InParanoid	P56750	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P56750
InterPro	IPR004031	http://www.ebi.ac.uk/interpro/entry/IPR004031
InterPro	IPR006187	http://www.ebi.ac.uk/interpro/entry/IPR006187
InterPro	IPR017974	http://www.ebi.ac.uk/interpro/entry/IPR017974
Jabion	26285	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=26285
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04516	http://www.genome.jp/dbget-bin/www_bget?ko04516
KEGG_Gene	hsa:26285	http://www.genome.jp/dbget-bin/www_bget?hsa:26285
KEGG_Orthology	KO:K06087	http://www.genome.jp/dbget-bin/www_bget?KO:K06087
KEGG_Pathway	ko04514	http://www.genome.jp/kegg-bin/show_pathway?ko04514
KEGG_Pathway	ko04530	http://www.genome.jp/kegg-bin/show_pathway?ko04530
KEGG_Pathway	ko04670	http://www.genome.jp/kegg-bin/show_pathway?ko04670
KEGG_Pathway	ko05160	http://www.genome.jp/kegg-bin/show_pathway?ko05160
MIM	617005	http://www.ncbi.nlm.nih.gov/omim/617005
OMA	QIQCTGS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QIQCTGS
OrthoDB	EOG091G0MX2	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0MX2
PANTHER	PTHR12002	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12002
PROSITE	PS01346	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01346
PSORT	swissprot:CLD17_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CLD17_HUMAN
PSORT-B	swissprot:CLD17_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CLD17_HUMAN
PSORT2	swissprot:CLD17_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CLD17_HUMAN
Pfam	PF00822	http://pfam.xfam.org/family/PF00822
PharmGKB	PA26564	http://www.pharmgkb.org/do/serve?objId=PA26564&objCls=Gene
Phobius	swissprot:CLD17_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CLD17_HUMAN
PhylomeDB	P56750	http://phylomedb.org/?seqid=P56750
ProteinModelPortal	P56750	http://www.proteinmodelportal.org/query/uniprot/P56750
PubMed	10830953	http://www.ncbi.nlm.nih.gov/pubmed/10830953
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	22402829	http://www.ncbi.nlm.nih.gov/pubmed/22402829
PubMed	26194246	http://www.ncbi.nlm.nih.gov/pubmed/26194246
Reactome	R-HSA-420029	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-420029
RefSeq	NP_036263	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_036263
SMR	P56750	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P56750
STRING	9606.ENSP00000286808	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000286808&targetmode=cogs
TCDB	1.H.1.1.13	http://www.tcdb.org/search/result.php?tc=1.H.1.1.13
UCSC	uc011acv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc011acv&org=rat
UniGene	Hs.258589	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.258589
UniProtKB	CLD17_HUMAN	http://www.uniprot.org/uniprot/CLD17_HUMAN
UniProtKB-AC	P56750	http://www.uniprot.org/uniprot/P56750
charge	swissprot:CLD17_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CLD17_HUMAN
eggNOG	ENOG410IJK4	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IJK4
eggNOG	ENOG410YQQY	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YQQY
epestfind	swissprot:CLD17_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CLD17_HUMAN
garnier	swissprot:CLD17_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CLD17_HUMAN
helixturnhelix	swissprot:CLD17_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLD17_HUMAN
hmoment	swissprot:CLD17_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CLD17_HUMAN
iep	swissprot:CLD17_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CLD17_HUMAN
inforesidue	swissprot:CLD17_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CLD17_HUMAN
neXtProt	NX_P56750	http://www.nextprot.org/db/entry/NX_P56750
octanol	swissprot:CLD17_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CLD17_HUMAN
pepcoil	swissprot:CLD17_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CLD17_HUMAN
pepdigest	swissprot:CLD17_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CLD17_HUMAN
pepinfo	swissprot:CLD17_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CLD17_HUMAN
pepnet	swissprot:CLD17_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CLD17_HUMAN
pepstats	swissprot:CLD17_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CLD17_HUMAN
pepwheel	swissprot:CLD17_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CLD17_HUMAN
pepwindow	swissprot:CLD17_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CLD17_HUMAN
sigcleave	swissprot:CLD17_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CLD17_HUMAN
## Database	ID	URL or Descriptions
# AltName	ANO5_HUMAN	Gnathodiaphyseal dysplasia 1 protein
# AltName	ANO5_HUMAN	Transmembrane protein 16E
# BioGrid	128482	2
# ChiTaRS	ANO5	human
# DISEASE	ANO5_HUMAN	Gnathodiaphyseal dysplasia (GDD) [MIM 166260]  Rare skeletal syndrome characterized by bone fragility, sclerosis of tubular bones, and cemento-osseous lesions of the jawbone. Patients experience frequent bone fractures caused by trivial accidents in childhood; however the fractures heal normally without bone deformity. The jaw lesions replace the tooth-bearing segments of the maxilla and mandible with fibrous connective tissues, including various amounts of cementum-like calcified mass, sometimes causing facial deformities. Patients also have a propensity for jaw infection and often suffer from purulent osteomyelitis-like symptoms, such as swelling of and pus discharge from the gums, mobility of the teeth, insufficient healing after tooth extraction and exposure of the lesions into the oral cavity. {ECO 0000269|PubMed 15124103, ECO 0000269|PubMed 23047743, ECO 0000269|PubMed 27216912}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ANO5_HUMAN	Limb-girdle muscular dystrophy 2L (LGMD2L) [MIM 611307]  An autosomal recessive degenerative myopathy characterized by proximal weakness, weakness of the hip and shoulder girdles and prominent asymmetrical quadriceps femoris and biceps brachii atrophy. {ECO 0000269|PubMed 20096397}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ANO5_HUMAN	Miyoshi muscular dystrophy 3 (MMD3) [MIM 613319]  A late- onset muscular dystrophy characterized by distal muscle weakness of the lower limbs, calf muscle discomfort and weakness, quadriceps atrophy. Muscle weakness and atrophy may be asymmetric. {ECO 0000269|PubMed 20096397, ECO 0000269|PubMed 22499103}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000324559	ENSP00000315371; ENSG00000171714
# FUNCTION	ANO5_HUMAN	Does not exhibit calcium-activated chloride channel (CaCC) activity. {ECO 0000269|PubMed 20056604, ECO 0000269|PubMed 23047743}. 
# GO_component	GO:0005622	intracellular; IDA:UniProtKB.
# GO_component	GO:0005789	endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0031982	vesicle; IEA:Ensembl.
# GO_function	GO:0005229	intracellular calcium activated chloride channel activity; IDA:UniProtKB.
# GO_process	GO:0006821	chloride transport; IDA:UniProtKB.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005622	intracellular
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q75V66	HS
# HGNC	HGNC:27337	ANO5
# InterPro	IPR007632	Anoctamin
# InterPro	IPR031294	Anoctamin-5
# InterPro	IPR032394	Anoct_dimer
# KEGG_Disease	H00498	[Skeletal dysplasia] Gnathodiaphyseal dysplasia
# KEGG_Disease	H00593	[Musculoskeletal disease; Nervous system disease] Limb-girdle muscular dystrophy (LGMD)
# KEGG_Disease	H00594	[Musculoskeletal disease; Nervous system disease] Distal myopathy 3 (MPD2, VCPDM)
# MIM	166260	phenotype
# MIM	608662	gene
# MIM	611307	phenotype
# MIM	613319	phenotype
# MISCELLANEOUS	ANO5_HUMAN	The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology. 
# Organism	ANO5_HUMAN	Homo sapiens (Human)
# Orphanet	206549	Autosomal recessive limb-girdle muscular dystrophy type 2L
# Orphanet	399096	Distal anoctaminopathy
# Orphanet	53697	Gnathodiaphyseal dysplasia
# PANTHER	PTHR12308	PTHR12308
# PANTHER	PTHR12308:SF23	PTHR12308:SF23
# Pfam	PF04547	Anoctamin
# Pfam	PF16178	Anoct_dimer
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	ANO5_HUMAN	Anoctamin-5
# RefSeq	NP_001136121	NM_001142649.1
# RefSeq	NP_998764	NM_213599.2
# SIMILARITY	Belongs to the anoctamin family. {ECO	0000305}.
# SUBCELLULAR LOCATION	ANO5_HUMAN	Endoplasmic reticulum membrane {ECO 0000269|PubMed 15124103}; Multi-pass membrane protein {ECO 0000255}. Cell membrane {ECO 0000269|PubMed 20056604, ECO 0000269|PubMed 22946059}; Multi-pass membrane protein {ECO 0000255}. Note=Colocalized with CALR/calreticulin (PubMed 15124103). Shows an intracellular localization according to PubMed 22075693. {ECO 0000269|PubMed 15124103, ECO 0000269|PubMed 22075693}. 
# TCDB	1.A.17.1.21	the calcium-dependent chloride channel (ca-clc) family
# TISSUE SPECIFICITY	ANO5_HUMAN	Highly expressed in brain, heart, kidney, lung, and skeletal muscle. Weakly expressed in bone marrow, fetal liver, placenta, spleen, thymus, osteoblasts and periodontal ligament cells. {ECO 0000269|PubMed 15067359, ECO 0000269|PubMed 15124103}. 
# UCSC	uc001mqi	human
# eggNOG	ENOG410XS4S	LUCA
# eggNOG	KOG2514	Eukaryota
BLAST	swissprot:ANO5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ANO5_HUMAN
COXPRESdb	203859	http://coxpresdb.jp/data/gene/203859.shtml
CleanEx	HS_ANO5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ANO5
DOI	10.1002/mus.23281	http://dx.doi.org/10.1002/mus.23281
DOI	10.1007/s00424-011-0975-9	http://dx.doi.org/10.1007/s00424-011-0975-9
DOI	10.1016/j.ajhg.2009.12.013	http://dx.doi.org/10.1016/j.ajhg.2009.12.013
DOI	10.1038/aps.2011.48	http://dx.doi.org/10.1038/aps.2011.48
DOI	10.1038/ejhg.2012.224	http://dx.doi.org/10.1038/ejhg.2012.224
DOI	10.1038/srep26440	http://dx.doi.org/10.1038/srep26440
DOI	10.1074/jbc.M109.065367	http://dx.doi.org/10.1074/jbc.M109.065367
DOI	10.1086/421527	http://dx.doi.org/10.1086/421527
DOI	10.1113/expphysiol.2011.058214	http://dx.doi.org/10.1113/expphysiol.2011.058214
DOI	10.1152/ajpcell.00140.2011	http://dx.doi.org/10.1152/ajpcell.00140.2011
DOI	10.1242/jcs.109553	http://dx.doi.org/10.1242/jcs.109553
EMBL	AB125267	http://www.ebi.ac.uk/ena/data/view/AB125267
Ensembl	ENST00000324559	http://www.ensembl.org/id/ENST00000324559
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0031982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031982
GO_function	GO:0005229	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005229
GO_process	GO:0006821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006821
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ANO5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ANO5
GeneID	203859	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=203859
GeneTree	ENSGT00760000119015	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119015
HGNC	HGNC:27337	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:27337
HOGENOM	HOG000006509	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006509&db=HOGENOM6
HOVERGEN	HBG069519	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG069519&db=HOVERGEN
HPA	HPA058857	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA058857
InParanoid	Q75V66	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q75V66
IntAct	Q75V66	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q75V66*
InterPro	IPR007632	http://www.ebi.ac.uk/interpro/entry/IPR007632
InterPro	IPR031294	http://www.ebi.ac.uk/interpro/entry/IPR031294
InterPro	IPR032394	http://www.ebi.ac.uk/interpro/entry/IPR032394
Jabion	203859	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=203859
KEGG_Disease	H00498	http://www.genome.jp/dbget-bin/www_bget?H00498
KEGG_Disease	H00593	http://www.genome.jp/dbget-bin/www_bget?H00593
KEGG_Disease	H00594	http://www.genome.jp/dbget-bin/www_bget?H00594
KEGG_Gene	hsa:203859	http://www.genome.jp/dbget-bin/www_bget?hsa:203859
MIM	166260	http://www.ncbi.nlm.nih.gov/omim/166260
MIM	608662	http://www.ncbi.nlm.nih.gov/omim/608662
MIM	611307	http://www.ncbi.nlm.nih.gov/omim/611307
MIM	613319	http://www.ncbi.nlm.nih.gov/omim/613319
OMA	FTTCRYR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FTTCRYR
Orphanet	206549	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=206549
Orphanet	399096	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=399096
Orphanet	53697	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=53697
OrthoDB	EOG091G01JF	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01JF
PANTHER	PTHR12308	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12308
PANTHER	PTHR12308:SF23	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12308:SF23
PSORT	swissprot:ANO5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ANO5_HUMAN
PSORT-B	swissprot:ANO5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ANO5_HUMAN
PSORT2	swissprot:ANO5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ANO5_HUMAN
Pfam	PF04547	http://pfam.xfam.org/family/PF04547
Pfam	PF16178	http://pfam.xfam.org/family/PF16178
PharmGKB	PA164715641	http://www.pharmgkb.org/do/serve?objId=PA164715641&objCls=Gene
Phobius	swissprot:ANO5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ANO5_HUMAN
PhylomeDB	Q75V66	http://phylomedb.org/?seqid=Q75V66
ProteinModelPortal	Q75V66	http://www.proteinmodelportal.org/query/uniprot/Q75V66
PubMed	15067359	http://www.ncbi.nlm.nih.gov/pubmed/15067359
PubMed	15124103	http://www.ncbi.nlm.nih.gov/pubmed/15124103
PubMed	20056604	http://www.ncbi.nlm.nih.gov/pubmed/20056604
PubMed	20096397	http://www.ncbi.nlm.nih.gov/pubmed/20096397
PubMed	21607626	http://www.ncbi.nlm.nih.gov/pubmed/21607626
PubMed	21642943	http://www.ncbi.nlm.nih.gov/pubmed/21642943
PubMed	22075693	http://www.ncbi.nlm.nih.gov/pubmed/22075693
PubMed	22302790	http://www.ncbi.nlm.nih.gov/pubmed/22302790
PubMed	22499103	http://www.ncbi.nlm.nih.gov/pubmed/22499103
PubMed	22946059	http://www.ncbi.nlm.nih.gov/pubmed/22946059
PubMed	23047743	http://www.ncbi.nlm.nih.gov/pubmed/23047743
PubMed	27216912	http://www.ncbi.nlm.nih.gov/pubmed/27216912
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_001136121	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001136121
RefSeq	NP_998764	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_998764
STRING	9606.ENSP00000315371	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000315371&targetmode=cogs
TCDB	1.A.17.1.21	http://www.tcdb.org/search/result.php?tc=1.A.17.1.21
UCSC	uc001mqi	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001mqi&org=rat
UniGene	Hs.154329	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.154329
UniProtKB	ANO5_HUMAN	http://www.uniprot.org/uniprot/ANO5_HUMAN
UniProtKB-AC	Q75V66	http://www.uniprot.org/uniprot/Q75V66
charge	swissprot:ANO5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ANO5_HUMAN
eggNOG	ENOG410XS4S	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS4S
eggNOG	KOG2514	http://eggnogapi.embl.de/nog_data/html/tree/KOG2514
epestfind	swissprot:ANO5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ANO5_HUMAN
garnier	swissprot:ANO5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ANO5_HUMAN
helixturnhelix	swissprot:ANO5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ANO5_HUMAN
hmoment	swissprot:ANO5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ANO5_HUMAN
iep	swissprot:ANO5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ANO5_HUMAN
inforesidue	swissprot:ANO5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ANO5_HUMAN
neXtProt	NX_Q75V66	http://www.nextprot.org/db/entry/NX_Q75V66
octanol	swissprot:ANO5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ANO5_HUMAN
pepcoil	swissprot:ANO5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ANO5_HUMAN
pepdigest	swissprot:ANO5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ANO5_HUMAN
pepinfo	swissprot:ANO5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ANO5_HUMAN
pepnet	swissprot:ANO5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ANO5_HUMAN
pepstats	swissprot:ANO5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ANO5_HUMAN
pepwheel	swissprot:ANO5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ANO5_HUMAN
pepwindow	swissprot:ANO5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ANO5_HUMAN
sigcleave	swissprot:ANO5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ANO5_HUMAN
## Database	ID	URL or Descriptions
# AltName	YLAT1_HUMAN	Monocyte amino acid permease 2
# AltName	YLAT1_HUMAN	Solute carrier family 7 member 7
# AltName	YLAT1_HUMAN	y(+)L-type amino acid transporter 1
# BIOPHYSICOCHEMICAL PROPERTIES	YLAT1_HUMAN	Kinetic parameters  KM=31.7 uM for L-leucine (in the presence of 0.1 M NaCl) {ECO 0000269|PubMed 9878049}; KM=16.2 uM for L-leucine (in the presence of 0.1 M LiCl) {ECO 0000269|PubMed 9878049}; 
# BioGrid	114518	2
# ChiTaRS	SLC7A7	human
# DISEASE	YLAT1_HUMAN	Lysinuric protein intolerance (LPI) [MIM 222700]  A metabolic disorder characterized by increased renal excretion of cationic amino acid (CAA), reduced CAA absorption from intestine, and orotic aciduria. On a normal diet, LPI patients present poor feeding, vomiting, diarrhea, episodes of hyperammoniaemic coma and growth retardation. Hepatosplenomegaly, osteoporosis and a life- threatening pulmonary involvement (alveolar proteinosis) are also seen. Biochemically LPI is characterized by defective transport of dibasic amino acids at the basolateral membrane of epithelial cells in kidney and intestine. {ECO 0000269|PubMed 10080182, ECO 0000269|PubMed 10631139, ECO 0000269|PubMed 10655553, ECO 0000269|PubMed 12402335, ECO 0000269|PubMed 15776427, ECO 0000269|PubMed 17764084, ECO 0000269|PubMed 9829974}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# ENZYME REGULATION	YLAT1_HUMAN	Arginine transport is inhibited by protein kinase C (PKC) and treatment with phorbol-12-myristate-13-acetate (PMA). 
# Ensembl	ENST00000285850	ENSP00000285850; ENSG00000155465
# Ensembl	ENST00000397528	ENSP00000380662; ENSG00000155465
# Ensembl	ENST00000397529	ENSP00000380663; ENSG00000155465
# Ensembl	ENST00000397532	ENSP00000380666; ENSG00000155465
# Ensembl	ENST00000555702	ENSP00000451881; ENSG00000155465
# ExpressionAtlas	Q9UM01	baseline and differential
# FUNCTION	YLAT1_HUMAN	Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L- arginine in monocytes. {ECO 0000269|PubMed 14603368, ECO 0000269|PubMed 15280038, ECO 0000269|PubMed 17329401, ECO 0000269|PubMed 9829974, ECO 0000269|PubMed 9878049}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0015174	basic amino acid transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015179	L-amino acid transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015297	antiporter activity; IBA:GO_Central.
# GO_process	GO:0000821	regulation of arginine metabolic process; IBA:GO_Central.
# GO_process	GO:0006461	protein complex assembly; TAS:ProtInc.
# GO_process	GO:0006520	cellular amino acid metabolic process; TAS:ProtInc.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006865	amino acid transport; TAS:Reactome.
# GO_process	GO:0050900	leukocyte migration; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006520	cellular amino acid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048870	cell motility
# Genevisible	Q9UM01	HS
# HGNC	HGNC:11065	SLC7A7
# INDUCTION	Expression is stimulated and enhanced by IFNG/IFN- gamma. {ECO:0000269|PubMed	15280038}. 
# InterPro	IPR002293	AA/rel_permease1
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H00899	[Urinary system disease; Inherited metabolic disease] Lysinuric protein intolerance (LPI)
# KEGG_Disease	H01400:[Inherited metabolic disease] Glutamine synthetase deficiency [DS	H00923]
# KEGG_Pathway	ko04974	Protein digestion and absorption
# MIM	222700	phenotype
# MIM	603593	gene
# Organism	YLAT1_HUMAN	Homo sapiens (Human)
# Orphanet	470	Lysinuric protein intolerance
# PANTHER	PTHR11785	PTHR11785
# PIRSF	PIRSF006060	AA_transporter
# Pfam	PF13520	AA_permease_2
# Proteomes	UP000005640	Chromosome 14
# Reactome	R-HSA-210991	Basigin interactions
# Reactome	R-HSA-352230	Amino acid transport across the plasma membrane
# RecName	YLAT1_HUMAN	Y+L amino acid transporter 1
# RefSeq	NP_001119577	NM_001126105.2
# RefSeq	NP_001119578	NM_001126106.2
# RefSeq	XP_006720365	XM_006720302.1
# RefSeq	XP_011535600	XM_011537298.2
# RefSeq	XP_011535601	XM_011537299.1
# SEQUENCE CAUTION	Sequence=BAA95120.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAD62619.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	YLAT1_HUMAN	Basolateral cell membrane {ECO 0000269|PubMed 15756301}; Multi-pass membrane protein {ECO 0000269|PubMed 15756301}. 
# SUBUNIT	YLAT1_HUMAN	Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc. {ECO 0000269|PubMed 9829974, ECO 0000269|PubMed 9878049}. 
# TCDB	2.A.3.8.22	the amino acid-polyamine-organocation (apc) family
# TISSUE SPECIFICITY	YLAT1_HUMAN	Highest expression in kidney and peripheral blood leukocytes. Weaker expression is observed in lung, heart, placenta, spleen, testis and small intestine. Expressed in normal fibroblasts and those from LPI patients. Also expressed in HUVECs, monocytes, retinal pigment epithelial cells, and various carcinoma cell lines, with highest expression in a colon-carcinoma cell line. {ECO 0000269|PubMed 10080183, ECO 0000269|PubMed 11078698, ECO 0000269|PubMed 11742806, ECO 0000269|PubMed 15280038, ECO 0000269|PubMed 17197568, ECO 0000269|PubMed 17329401, ECO 0000269|PubMed 9829974}. 
# UCSC	uc001wgr	human
# eggNOG	COG0531	LUCA
# eggNOG	KOG1287	Eukaryota
BLAST	swissprot:YLAT1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:YLAT1_HUMAN
BioCyc	ZFISH:ENSG00000155465-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000155465-MONOMER
COXPRESdb	9056	http://coxpresdb.jp/data/gene/9056.shtml
CleanEx	HS_SLC7A7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC7A7
DOI	10.1002/(SICI)1098-1004(200004)15:4<367::AID-HUMU9>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(200004)15:4<367::AID-HUMU9>3.0.CO
DOI	10.1002/humu.10140	http://dx.doi.org/10.1002/humu.10140
DOI	10.1002/humu.20589	http://dx.doi.org/10.1002/humu.20589
DOI	10.1002/humu.9323	http://dx.doi.org/10.1002/humu.9323
DOI	10.1016/j.febslet.2004.06.086	http://dx.doi.org/10.1016/j.febslet.2004.06.086
DOI	10.1038/6809	http://dx.doi.org/10.1038/6809
DOI	10.1038/6815	http://dx.doi.org/10.1038/6815
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.ejhg.5201376	http://dx.doi.org/10.1038/sj.ejhg.5201376
DOI	10.1074/jbc.273.49.32437	http://dx.doi.org/10.1074/jbc.273.49.32437
DOI	10.1086/302700	http://dx.doi.org/10.1086/302700
DOI	10.1093/emboj/18.1.49	http://dx.doi.org/10.1093/emboj/18.1.49
DOI	10.1093/hmg/9.3.431	http://dx.doi.org/10.1093/hmg/9.3.431
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1113/eph8802647	http://dx.doi.org/10.1113/eph8802647
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1152/ajpcell.00323.2006	http://dx.doi.org/10.1152/ajpcell.00323.2006
DOI	10.1167/iovs.06-0398	http://dx.doi.org/10.1167/iovs.06-0398
EMBL	AB011263	http://www.ebi.ac.uk/ena/data/view/AB011263
EMBL	AB020532	http://www.ebi.ac.uk/ena/data/view/AB020532
EMBL	AB031537	http://www.ebi.ac.uk/ena/data/view/AB031537
EMBL	AF092032	http://www.ebi.ac.uk/ena/data/view/AF092032
EMBL	AJ130718	http://www.ebi.ac.uk/ena/data/view/AJ130718
EMBL	AK314351	http://www.ebi.ac.uk/ena/data/view/AK314351
EMBL	BC003062	http://www.ebi.ac.uk/ena/data/view/BC003062
EMBL	BC010107	http://www.ebi.ac.uk/ena/data/view/BC010107
EMBL	BX161519	http://www.ebi.ac.uk/ena/data/view/BX161519
EMBL	BX248291	http://www.ebi.ac.uk/ena/data/view/BX248291
EMBL	CH471078	http://www.ebi.ac.uk/ena/data/view/CH471078
EMBL	CH471078	http://www.ebi.ac.uk/ena/data/view/CH471078
EMBL	CH471078	http://www.ebi.ac.uk/ena/data/view/CH471078
EMBL	CH471078	http://www.ebi.ac.uk/ena/data/view/CH471078
EMBL	Y18474	http://www.ebi.ac.uk/ena/data/view/Y18474
Ensembl	ENST00000285850	http://www.ensembl.org/id/ENST00000285850
Ensembl	ENST00000397528	http://www.ensembl.org/id/ENST00000397528
Ensembl	ENST00000397529	http://www.ensembl.org/id/ENST00000397529
Ensembl	ENST00000397532	http://www.ensembl.org/id/ENST00000397532
Ensembl	ENST00000555702	http://www.ensembl.org/id/ENST00000555702
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_function	GO:0015174	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015174
GO_function	GO:0015179	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015179
GO_function	GO:0015297	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297
GO_process	GO:0000821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000821
GO_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GO_process	GO:0006520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GO_process	GO:0050900	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050900
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GeneCards	SLC7A7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC7A7
GeneID	9056	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9056
GeneTree	ENSGT00760000119037	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119037
HGNC	HGNC:11065	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11065
HOVERGEN	HBG000476	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000476&db=HOVERGEN
HPA	HPA036227	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA036227
InParanoid	Q9UM01	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UM01
IntAct	Q9UM01	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9UM01*
InterPro	IPR002293	http://www.ebi.ac.uk/interpro/entry/IPR002293
Jabion	9056	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9056
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00899	http://www.genome.jp/dbget-bin/www_bget?H00899
KEGG_Disease	H01400	http://www.genome.jp/dbget-bin/www_bget?H01400
KEGG_Gene	hsa:9056	http://www.genome.jp/dbget-bin/www_bget?hsa:9056
KEGG_Orthology	KO:K13867	http://www.genome.jp/dbget-bin/www_bget?KO:K13867
KEGG_Pathway	ko04974	http://www.genome.jp/kegg-bin/show_pathway?ko04974
MIM	222700	http://www.ncbi.nlm.nih.gov/omim/222700
MIM	603593	http://www.ncbi.nlm.nih.gov/omim/603593
OMA	DFLCMIH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DFLCMIH
Orphanet	470	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=470
OrthoDB	EOG091G07EM	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07EM
PANTHER	PTHR11785	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785
PSORT	swissprot:YLAT1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:YLAT1_HUMAN
PSORT-B	swissprot:YLAT1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:YLAT1_HUMAN
PSORT2	swissprot:YLAT1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:YLAT1_HUMAN
Pfam	PF13520	http://pfam.xfam.org/family/PF13520
PharmGKB	PA35925	http://www.pharmgkb.org/do/serve?objId=PA35925&objCls=Gene
Phobius	swissprot:YLAT1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:YLAT1_HUMAN
PhylomeDB	Q9UM01	http://phylomedb.org/?seqid=Q9UM01
ProteinModelPortal	Q9UM01	http://www.proteinmodelportal.org/query/uniprot/Q9UM01
PubMed	10080182	http://www.ncbi.nlm.nih.gov/pubmed/10080182
PubMed	10080183	http://www.ncbi.nlm.nih.gov/pubmed/10080183
PubMed	10631139	http://www.ncbi.nlm.nih.gov/pubmed/10631139
PubMed	10655553	http://www.ncbi.nlm.nih.gov/pubmed/10655553
PubMed	10737982	http://www.ncbi.nlm.nih.gov/pubmed/10737982
PubMed	11078698	http://www.ncbi.nlm.nih.gov/pubmed/11078698
PubMed	11742806	http://www.ncbi.nlm.nih.gov/pubmed/11742806
PubMed	12402335	http://www.ncbi.nlm.nih.gov/pubmed/12402335
PubMed	14603368	http://www.ncbi.nlm.nih.gov/pubmed/14603368
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15280038	http://www.ncbi.nlm.nih.gov/pubmed/15280038
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15756301	http://www.ncbi.nlm.nih.gov/pubmed/15756301
PubMed	15776427	http://www.ncbi.nlm.nih.gov/pubmed/15776427
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	17197568	http://www.ncbi.nlm.nih.gov/pubmed/17197568
PubMed	17329401	http://www.ncbi.nlm.nih.gov/pubmed/17329401
PubMed	17764084	http://www.ncbi.nlm.nih.gov/pubmed/17764084
PubMed	9829974	http://www.ncbi.nlm.nih.gov/pubmed/9829974
PubMed	9878049	http://www.ncbi.nlm.nih.gov/pubmed/9878049
Reactome	R-HSA-210991	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-210991
Reactome	R-HSA-352230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-352230
RefSeq	NP_001119577	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001119577
RefSeq	NP_001119578	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001119578
RefSeq	XP_006720365	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006720365
RefSeq	XP_011535600	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011535600
RefSeq	XP_011535601	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011535601
STRING	9606.ENSP00000285850	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000285850&targetmode=cogs
TCDB	2.A.3.8.22	http://www.tcdb.org/search/result.php?tc=2.A.3.8.22
UCSC	uc001wgr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001wgr&org=rat
UniGene	Hs.513147	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.513147
UniGene	Hs.732349	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.732349
UniProtKB	YLAT1_HUMAN	http://www.uniprot.org/uniprot/YLAT1_HUMAN
UniProtKB-AC	Q9UM01	http://www.uniprot.org/uniprot/Q9UM01
charge	swissprot:YLAT1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:YLAT1_HUMAN
eggNOG	COG0531	http://eggnogapi.embl.de/nog_data/html/tree/COG0531
eggNOG	KOG1287	http://eggnogapi.embl.de/nog_data/html/tree/KOG1287
epestfind	swissprot:YLAT1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:YLAT1_HUMAN
garnier	swissprot:YLAT1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:YLAT1_HUMAN
helixturnhelix	swissprot:YLAT1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:YLAT1_HUMAN
hmoment	swissprot:YLAT1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:YLAT1_HUMAN
iep	swissprot:YLAT1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:YLAT1_HUMAN
inforesidue	swissprot:YLAT1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:YLAT1_HUMAN
neXtProt	NX_Q9UM01	http://www.nextprot.org/db/entry/NX_Q9UM01
octanol	swissprot:YLAT1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:YLAT1_HUMAN
pepcoil	swissprot:YLAT1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:YLAT1_HUMAN
pepdigest	swissprot:YLAT1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:YLAT1_HUMAN
pepinfo	swissprot:YLAT1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:YLAT1_HUMAN
pepnet	swissprot:YLAT1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:YLAT1_HUMAN
pepstats	swissprot:YLAT1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:YLAT1_HUMAN
pepwheel	swissprot:YLAT1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:YLAT1_HUMAN
pepwindow	swissprot:YLAT1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:YLAT1_HUMAN
sigcleave	swissprot:YLAT1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:YLAT1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	RASA3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14644-1; Sequence=Displayed; Name=2; IsoId=Q14644-2; Sequence=VSP_056141; Note=No experimental confirmation available.; 
# AltName	RASA3_HUMAN	GAP1(IP4BP)
# AltName	RASA3_HUMAN	Ins P4-binding protein
# BioGrid	116497	8
# CCDS	CCDS32016	-. [Q14644-1]
# ChiTaRS	RASA3	human
# Ensembl	ENST00000334062	ENSP00000335029; ENSG00000185989. [Q14644-1]
# Ensembl	ENST00000630618	ENSP00000486064; ENSG00000280477. [Q14644-1]
# FUNCTION	RASA3_HUMAN	Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor. 
# GO_component	GO:0005737	cytoplasm; IBA:GO_Central.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane; IDA:BHF-UCL.
# GO_function	GO:0005096	GTPase activator activity; TAS:ProtInc.
# GO_function	GO:0015278	calcium-release channel activity; IDA:BHF-UCL.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0000165	MAPK cascade; TAS:Reactome.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0046580	negative regulation of Ras protein signal transduction; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0030234	enzyme regulator activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.10.506.10	-; 1.
# Gene3D	2.30.29.30	-; 1.
# Gene3D	2.60.40.150	-; 2.
# Genevisible	Q14644	HS
# HGNC	HGNC:20331	RASA3
# InterPro	IPR000008	C2_dom
# InterPro	IPR001562	Znf_Btk_motif
# InterPro	IPR001849	PH_domain
# InterPro	IPR001936	RasGAP_dom
# InterPro	IPR008936	Rho_GTPase_activation_prot
# InterPro	IPR011993	PH_dom-like
# InterPro	IPR023152	RasGAP_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Pathway	ko04013	MAPK signaling pathway - fly
# MIM	605182	gene
# Organism	RASA3_HUMAN	Homo sapiens (Human)
# PRINTS	PR00402	TECBTKDOMAIN
# PROSITE	PS00509	RAS_GTPASE_ACTIV_1
# PROSITE	PS50003	PH_DOMAIN
# PROSITE	PS50004	C2; 2
# PROSITE	PS50018	RAS_GTPASE_ACTIV_2
# PROSITE	PS51113	ZF_BTK
# Pfam	PF00168	C2; 2
# Pfam	PF00169	PH
# Pfam	PF00616	RasGAP; 2
# Pfam	PF00779	BTK
# Proteomes	UP000005640	Chromosome 13
# Reactome	R-HSA-5658442	Regulation of RAS by GAPs
# Reactome	R-HSA-6802949	Signaling by RAS mutants
# Reactome	R-HSA-8849471	PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
# RecName	RASA3_HUMAN	Ras GTPase-activating protein 3
# RefSeq	NP_001307750	NM_001320821.1
# RefSeq	NP_001307751	NM_001320822.1. [Q14644-2]
# RefSeq	NP_031394	NM_007368.3. [Q14644-1]
# RefSeq	XP_011533143	XM_011534841.2. [Q14644-2]
# RefSeq	XP_011533144	XM_011534842.2. [Q14644-2]
# SIMILARITY	Contains 1 Btk-type zinc finger. {ECO:0000255|PROSITE- ProRule	PRU00432}. 
# SIMILARITY	Contains 1 PH domain. {ECO:0000255|PROSITE- ProRule	PRU00145}. 
# SIMILARITY	Contains 1 Ras-GAP domain. {ECO:0000255|PROSITE- ProRule	PRU00167}.
# SIMILARITY	Contains 2 C2 domains. {ECO:0000255|PROSITE- ProRule	PRU00041}. 
# SMART	SM00107	BTK
# SMART	SM00233	PH
# SMART	SM00239	C2; 2
# SMART	SM00323	RasGAP
# SUBCELLULAR LOCATION	RASA3_HUMAN	Cell membrane. 
# SUPFAM	SSF48350	SSF48350
# SUPFAM	SSF49562	SSF49562; 2
# SUPFAM	SSF50729	SSF50729
# UCSC	uc001vui	human. [Q14644-1]
# eggNOG	ENOG410Y128	LUCA
# eggNOG	KOG2059	Eukaryota
BLAST	swissprot:RASA3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:RASA3_HUMAN
BioCyc	ZFISH:G66-32254-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32254-MONOMER
COXPRESdb	22821	http://coxpresdb.jp/data/gene/22821.shtml
CleanEx	HS_RASA3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_RASA3
DOI	10.1016/S0960-9822(06)00423-4	http://dx.doi.org/10.1016/S0960-9822(06)00423-4
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr0704130	http://dx.doi.org/10.1021/pr0704130
DOI	10.1021/pr0705441	http://dx.doi.org/10.1021/pr0705441
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/376527a0	http://dx.doi.org/10.1038/376527a0
DOI	10.1038/nature02379	http://dx.doi.org/10.1038/nature02379
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
EMBL	AK289746	http://www.ebi.ac.uk/ena/data/view/AK289746
EMBL	AK294913	http://www.ebi.ac.uk/ena/data/view/AK294913
EMBL	AL161774	http://www.ebi.ac.uk/ena/data/view/AL161774
EMBL	AL161774	http://www.ebi.ac.uk/ena/data/view/AL161774
EMBL	BC038456	http://www.ebi.ac.uk/ena/data/view/BC038456
EMBL	BC047242	http://www.ebi.ac.uk/ena/data/view/BC047242
EMBL	BX537329	http://www.ebi.ac.uk/ena/data/view/BX537329
EMBL	BX537329	http://www.ebi.ac.uk/ena/data/view/BX537329
EMBL	X89399	http://www.ebi.ac.uk/ena/data/view/X89399
Ensembl	ENST00000334062	http://www.ensembl.org/id/ENST00000334062
Ensembl	ENST00000630618	http://www.ensembl.org/id/ENST00000630618
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0031235	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031235
GO_function	GO:0005096	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005096
GO_function	GO:0015278	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015278
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0000165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000165
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0046580	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046580
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0030234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.10.506.10	http://www.cathdb.info/version/latest/superfamily/1.10.506.10
Gene3D	2.30.29.30	http://www.cathdb.info/version/latest/superfamily/2.30.29.30
Gene3D	2.60.40.150	http://www.cathdb.info/version/latest/superfamily/2.60.40.150
GeneCards	RASA3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=RASA3
GeneID	22821	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22821
GeneTree	ENSGT00760000119092	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119092
HGNC	HGNC:20331	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20331
HOGENOM	HOG000007183	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007183&db=HOGENOM6
HOVERGEN	HBG055643	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG055643&db=HOVERGEN
HPA	HPA046759	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA046759
InParanoid	Q14644	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q14644
IntAct	Q14644	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q14644*
InterPro	IPR000008	http://www.ebi.ac.uk/interpro/entry/IPR000008
InterPro	IPR001562	http://www.ebi.ac.uk/interpro/entry/IPR001562
InterPro	IPR001849	http://www.ebi.ac.uk/interpro/entry/IPR001849
InterPro	IPR001936	http://www.ebi.ac.uk/interpro/entry/IPR001936
InterPro	IPR008936	http://www.ebi.ac.uk/interpro/entry/IPR008936
InterPro	IPR011993	http://www.ebi.ac.uk/interpro/entry/IPR011993
InterPro	IPR023152	http://www.ebi.ac.uk/interpro/entry/IPR023152
Jabion	22821	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=22821
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Gene	hsa:22821	http://www.genome.jp/dbget-bin/www_bget?hsa:22821
KEGG_Orthology	KO:K12380	http://www.genome.jp/dbget-bin/www_bget?KO:K12380
KEGG_Pathway	ko04013	http://www.genome.jp/kegg-bin/show_pathway?ko04013
MIM	605182	http://www.ncbi.nlm.nih.gov/omim/605182
OMA	SHKSCEI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SHKSCEI
OrthoDB	EOG091G04T8	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G04T8
PRINTS	PR00402	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00402
PROSITE	PS00509	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00509
PROSITE	PS50003	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50003
PROSITE	PS50004	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50004
PROSITE	PS50018	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50018
PROSITE	PS51113	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51113
PSORT	swissprot:RASA3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:RASA3_HUMAN
PSORT-B	swissprot:RASA3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:RASA3_HUMAN
PSORT2	swissprot:RASA3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:RASA3_HUMAN
Pfam	PF00168	http://pfam.xfam.org/family/PF00168
Pfam	PF00169	http://pfam.xfam.org/family/PF00169
Pfam	PF00616	http://pfam.xfam.org/family/PF00616
Pfam	PF00779	http://pfam.xfam.org/family/PF00779
PharmGKB	PA134905447	http://www.pharmgkb.org/do/serve?objId=PA134905447&objCls=Gene
Phobius	swissprot:RASA3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:RASA3_HUMAN
PhylomeDB	Q14644	http://phylomedb.org/?seqid=Q14644
ProteinModelPortal	Q14644	http://www.proteinmodelportal.org/query/uniprot/Q14644
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15057823	http://www.ncbi.nlm.nih.gov/pubmed/15057823
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18088087	http://www.ncbi.nlm.nih.gov/pubmed/18088087
PubMed	18220336	http://www.ncbi.nlm.nih.gov/pubmed/18220336
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	7637787	http://www.ncbi.nlm.nih.gov/pubmed/7637787
PubMed	9382842	http://www.ncbi.nlm.nih.gov/pubmed/9382842
Reactome	R-HSA-5658442	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5658442
Reactome	R-HSA-6802949	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6802949
Reactome	R-HSA-8849471	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8849471
RefSeq	NP_001307750	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001307750
RefSeq	NP_001307751	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001307751
RefSeq	NP_031394	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_031394
RefSeq	XP_011533143	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011533143
RefSeq	XP_011533144	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011533144
SMART	SM00107	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00107
SMART	SM00233	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00233
SMART	SM00239	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00239
SMART	SM00323	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00323
SMR	Q14644	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q14644
STRING	9606.ENSP00000335029	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000335029&targetmode=cogs
SUPFAM	SSF48350	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48350
SUPFAM	SSF49562	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49562
SUPFAM	SSF50729	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50729
UCSC	uc001vui	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001vui&org=rat
UniGene	Hs.593075	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.593075
UniProtKB	RASA3_HUMAN	http://www.uniprot.org/uniprot/RASA3_HUMAN
UniProtKB-AC	Q14644	http://www.uniprot.org/uniprot/Q14644
charge	swissprot:RASA3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:RASA3_HUMAN
eggNOG	ENOG410Y128	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y128
eggNOG	KOG2059	http://eggnogapi.embl.de/nog_data/html/tree/KOG2059
epestfind	swissprot:RASA3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:RASA3_HUMAN
garnier	swissprot:RASA3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:RASA3_HUMAN
helixturnhelix	swissprot:RASA3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:RASA3_HUMAN
hmoment	swissprot:RASA3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:RASA3_HUMAN
iep	swissprot:RASA3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:RASA3_HUMAN
inforesidue	swissprot:RASA3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:RASA3_HUMAN
neXtProt	NX_Q14644	http://www.nextprot.org/db/entry/NX_Q14644
octanol	swissprot:RASA3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:RASA3_HUMAN
pepcoil	swissprot:RASA3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:RASA3_HUMAN
pepdigest	swissprot:RASA3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:RASA3_HUMAN
pepinfo	swissprot:RASA3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:RASA3_HUMAN
pepnet	swissprot:RASA3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:RASA3_HUMAN
pepstats	swissprot:RASA3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:RASA3_HUMAN
pepwheel	swissprot:RASA3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:RASA3_HUMAN
pepwindow	swissprot:RASA3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:RASA3_HUMAN
sigcleave	swissprot:RASA3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:RASA3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	PK1L1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8TDX9-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q8TDX9-2; Sequence=VSP_013215, VSP_013216; Note=No experimental confirmation available.; 
# AltName	PK1L1_HUMAN	PC1-like 1 protein
# AltName	PK1L1_HUMAN	Polycystin-1L1
# CCDS	CCDS34633	-. [Q8TDX9-1]
# Ensembl	ENST00000289672	ENSP00000289672; ENSG00000158683. [Q8TDX9-1]
# ExpressionAtlas	Q8TDX9	baseline and differential
# FUNCTION	PK1L1_HUMAN	Component of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD2L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. Does not constitute the pore-forming subunit. Also involved in left/right axis specification downstream of nodal flow  forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning. {ECO 0000269|PubMed 24336289}. 
# GO_component	GO:0005929	cilium; ISS:BHF-UCL.
# GO_component	GO:0016020	membrane; TAS:UniProtKB.
# GO_component	GO:0034704	calcium channel complex; IDA:UniProtKB.
# GO_component	GO:0060170	ciliary membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0097730	non-motile cilium; IDA:UniProtKB.
# GO_function	GO:0005262	calcium channel activity; IDA:UniProtKB.
# GO_process	GO:0003127	detection of nodal flow; ISS:BHF-UCL.
# GO_process	GO:0016337	single organismal cell-cell adhesion; NAS:UniProtKB.
# GO_process	GO:0050982	detection of mechanical stimulus; IBA:GO_Central.
# GO_process	GO:0070986	left/right axis specification; ISS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005929	cilium
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0007155	cell adhesion
# GOslim_process	GO:0008150	biological_process
# Gene3D	2.60.40.670	-; 1.
# Gene3D	2.60.60.20	-; 1.
# Genevisible	Q8TDX9	HS
# HGNC	HGNC:18053	PKD1L1
# InterPro	IPR000601	PKD_dom
# InterPro	IPR001024	PLAT/LH2_dom
# InterPro	IPR002859	PKD/REJ-like
# InterPro	IPR013122	PKD1_2_channel
# InterPro	IPR014010	REJ_dom
# InterPro	IPR022409	PKD/Chitinase_dom
# KEGG_Brite	ko04040	Ion channels
# MIM	609721	gene
# Organism	PK1L1_HUMAN	Homo sapiens (Human)
# PROSITE	PS50093	PKD
# PROSITE	PS50095	PLAT
# PROSITE	PS51111	REJ
# Pfam	PF00801	PKD
# Pfam	PF01477	PLAT
# Pfam	PF02010	REJ
# Pfam	PF08016	PKD_channel
# Proteomes	UP000005640	Chromosome 7
# RecName	PK1L1_HUMAN	Polycystic kidney disease protein 1-like 1
# RefSeq	NP_612152	NM_138295.3. [Q8TDX9-1]
# SEQUENCE CAUTION	Sequence=AAQ89117.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the polycystin family. {ECO	0000305}. 
# SIMILARITY	Contains 1 GPS domain. {ECO	0000305}. 
# SIMILARITY	Contains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule	PRU00152}. 
# SIMILARITY	Contains 1 REJ domain. {ECO:0000255|PROSITE- ProRule	PRU00511}. 
# SIMILARITY	Contains 2 PKD domains. {ECO:0000255|PROSITE- ProRule	PRU00151}. 
# SMART	SM00089	PKD; 2
# SMART	SM00308	LH2
# SUBCELLULAR LOCATION	PK1L1_HUMAN	Cell projection, cilium membrane {ECO 0000269|PubMed 24336289}; Multi-pass membrane protein {ECO 0000269|PubMed 24336289}. 
# SUBUNIT	Heterodimer; heterodimerizes with PKD2 proteins to form a calcium channel. Interacts with PKD2L1; to form ciliary calcium channel. Interacts with PKD2. {ECO:0000269|PubMed	24336289}. 
# SUPFAM	SSF49299	SSF49299
# SUPFAM	SSF49723	SSF49723
# TCDB	1.A.5.1	the polycystin cation channel (pcc) family
# TISSUE SPECIFICITY	PK1L1_HUMAN	Detected in testis and in fetal and adult heart. 
# UCSC	uc003tny	human. [Q8TDX9-1]
# eggNOG	ENOG410IQ5F	Eukaryota
# eggNOG	ENOG410ZBZ7	LUCA
BLAST	swissprot:PK1L1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:PK1L1_HUMAN
BioCyc	ZFISH:ENSG00000158683-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000158683-MONOMER
COXPRESdb	168507	http://coxpresdb.jp/data/gene/168507.shtml
CleanEx	HS_PKD1L1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_PKD1L1
DOI	10.1006/geno.2002.6719	http://dx.doi.org/10.1006/geno.2002.6719
DOI	10.1016/j.ajhg.2010.08.015	http://dx.doi.org/10.1016/j.ajhg.2010.08.015
DOI	10.1038/nature12832	http://dx.doi.org/10.1038/nature12832
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
EMBL	AB061683	http://www.ebi.ac.uk/ena/data/view/AB061683
EMBL	AY358757	http://www.ebi.ac.uk/ena/data/view/AY358757
Ensembl	ENST00000289672	http://www.ensembl.org/id/ENST00000289672
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005929	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005929
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0034704	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034704
GO_component	GO:0060170	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060170
GO_component	GO:0097730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097730
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_process	GO:0003127	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003127
GO_process	GO:0016337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016337
GO_process	GO:0050982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050982
GO_process	GO:0070986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070986
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005929	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005929
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	2.60.40.670	http://www.cathdb.info/version/latest/superfamily/2.60.40.670
Gene3D	2.60.60.20	http://www.cathdb.info/version/latest/superfamily/2.60.60.20
GeneCards	PKD1L1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=PKD1L1
GeneID	168507	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=168507
GeneTree	ENSGT00700000104221	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00700000104221
HGNC	HGNC:18053	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18053
HOGENOM	HOG000115551	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000115551&db=HOGENOM6
HOVERGEN	HBG053602	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053602&db=HOVERGEN
HPA	HPA020422	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA020422
HPA	HPA022424	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA022424
InParanoid	Q8TDX9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8TDX9
InterPro	IPR000601	http://www.ebi.ac.uk/interpro/entry/IPR000601
InterPro	IPR001024	http://www.ebi.ac.uk/interpro/entry/IPR001024
InterPro	IPR002859	http://www.ebi.ac.uk/interpro/entry/IPR002859
InterPro	IPR013122	http://www.ebi.ac.uk/interpro/entry/IPR013122
InterPro	IPR014010	http://www.ebi.ac.uk/interpro/entry/IPR014010
InterPro	IPR022409	http://www.ebi.ac.uk/interpro/entry/IPR022409
Jabion	168507	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=168507
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:168507	http://www.genome.jp/dbget-bin/www_bget?hsa:168507
KEGG_Orthology	KO:K04987	http://www.genome.jp/dbget-bin/www_bget?KO:K04987
MIM	609721	http://www.ncbi.nlm.nih.gov/omim/609721
MINT	MINT-5002126	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5002126
OMA	KNMGPGK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KNMGPGK
OrthoDB	EOG091G004D	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G004D
PROSITE	PS50093	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50093
PROSITE	PS50095	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50095
PROSITE	PS51111	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51111
PSORT	swissprot:PK1L1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:PK1L1_HUMAN
PSORT-B	swissprot:PK1L1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:PK1L1_HUMAN
PSORT2	swissprot:PK1L1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:PK1L1_HUMAN
Pfam	PF00801	http://pfam.xfam.org/family/PF00801
Pfam	PF01477	http://pfam.xfam.org/family/PF01477
Pfam	PF02010	http://pfam.xfam.org/family/PF02010
Pfam	PF08016	http://pfam.xfam.org/family/PF08016
PharmGKB	PA38282	http://www.pharmgkb.org/do/serve?objId=PA38282&objCls=Gene
Phobius	swissprot:PK1L1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:PK1L1_HUMAN
PhylomeDB	Q8TDX9	http://phylomedb.org/?seqid=Q8TDX9
ProteinModelPortal	Q8TDX9	http://www.proteinmodelportal.org/query/uniprot/Q8TDX9
PubMed	11863367	http://www.ncbi.nlm.nih.gov/pubmed/11863367
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	20869035	http://www.ncbi.nlm.nih.gov/pubmed/20869035
PubMed	24336289	http://www.ncbi.nlm.nih.gov/pubmed/24336289
RefSeq	NP_612152	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_612152
SMART	SM00089	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00089
SMART	SM00308	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00308
STRING	9606.ENSP00000289672	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000289672&targetmode=cogs
SUPFAM	SSF49299	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49299
SUPFAM	SSF49723	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49723
TCDB	1.A.5.1	http://www.tcdb.org/search/result.php?tc=1.A.5.1
UCSC	uc003tny	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003tny&org=rat
UniGene	Hs.195979	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.195979
UniProtKB	PK1L1_HUMAN	http://www.uniprot.org/uniprot/PK1L1_HUMAN
UniProtKB-AC	Q8TDX9	http://www.uniprot.org/uniprot/Q8TDX9
charge	swissprot:PK1L1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:PK1L1_HUMAN
eggNOG	ENOG410IQ5F	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IQ5F
eggNOG	ENOG410ZBZ7	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZBZ7
epestfind	swissprot:PK1L1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:PK1L1_HUMAN
garnier	swissprot:PK1L1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:PK1L1_HUMAN
helixturnhelix	swissprot:PK1L1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:PK1L1_HUMAN
hmoment	swissprot:PK1L1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:PK1L1_HUMAN
iep	swissprot:PK1L1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:PK1L1_HUMAN
inforesidue	swissprot:PK1L1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:PK1L1_HUMAN
neXtProt	NX_Q8TDX9	http://www.nextprot.org/db/entry/NX_Q8TDX9
octanol	swissprot:PK1L1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:PK1L1_HUMAN
pepcoil	swissprot:PK1L1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:PK1L1_HUMAN
pepdigest	swissprot:PK1L1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:PK1L1_HUMAN
pepinfo	swissprot:PK1L1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:PK1L1_HUMAN
pepnet	swissprot:PK1L1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:PK1L1_HUMAN
pepstats	swissprot:PK1L1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:PK1L1_HUMAN
pepwheel	swissprot:PK1L1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:PK1L1_HUMAN
pepwindow	swissprot:PK1L1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:PK1L1_HUMAN
sigcleave	swissprot:PK1L1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:PK1L1_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNE3_HUMAN	MinK-related peptide 2
# AltName	KCNE3_HUMAN	Minimum potassium ion channel-related peptide 2
# AltName	KCNE3_HUMAN	Potassium channel subunit beta MiRP2
# BioGrid	115326	10
# CAUTION	KCNE3_HUMAN	Variant His-83 has been associated with periodic paralysis (PubMed 11207363 and PubMed 12414843). The association could not be confirmed by further studies leading to the conclusion that His-83 does not play a causative role in the disease (PubMed 14504341 and PubMed 15037716). {ECO 0000305}.
# ChiTaRS	KCNE3	human
# Ensembl	ENST00000310128	ENSP00000310557; ENSG00000175538
# Ensembl	ENST00000525550	ENSP00000433633; ENSG00000175538
# ExpressionAtlas	Q9Y6H6	baseline and differential
# FUNCTION	KCNE3_HUMAN	Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed 12954870). Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship. {ECO 0000250|UniProtKB Q9JJV7, ECO 0000269|PubMed 10646604, ECO 0000269|PubMed 12954870}. 
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IEA:Ensembl.
# GO_component	GO:0030425	dendrite; IDA:UniProtKB.
# GO_component	GO:0031982	vesicle; IDA:UniProtKB.
# GO_component	GO:0032809	neuronal cell body membrane; IDA:UniProtKB.
# GO_component	GO:0043204	perikaryon; IDA:UniProtKB.
# GO_component	GO:0045121	membrane raft; IDA:UniProtKB.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IEA:InterPro.
# GO_function	GO:0015459	potassium channel regulator activity; IDA:UniProtKB.
# GO_process	GO:0060306	regulation of membrane repolarization; IBA:GO_Central.
# GO_process	GO:1901387	positive regulation of voltage-gated calcium channel activity; IEA:Ensembl.
# GO_process	GO:1902260	negative regulation of delayed rectifier potassium channel activity; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q9Y6H6	HS
# HGNC	HGNC:6243	KCNE3
# IntAct	Q9Y6H6	10
# InterPro	IPR000369	K_chnl_KCNE
# InterPro	IPR005426	K_chnl_volt-dep_bsu_KCNE3
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00215:[Inherited metabolic disease; Nervous system disease; Muscular disease] Andersen-Tawil syndrome (ATS) [DS	H00748]
# KEGG_Disease	H00728	[Cardiovascular disease] Brugada syndrome (BRS)
# KEGG_Pathway	ko04974	Protein digestion and absorption
# MIM	604433	gene
# MIM	613119	phenotype
# Organism	KCNE3_HUMAN	Homo sapiens (Human)
# Orphanet	130	Brugada syndrome
# Orphanet	681	Hypokalemic periodic paralysis
# PANTHER	PTHR15282:SF6	PTHR15282:SF6
# PDB	2NDJ	NMR; -; A=1-103
# PRINTS	PR00168	KCNECHANNEL
# PRINTS	PR01606	KCNE3CHANNEL
# Pfam	PF02060	ISK_Channel
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-5576890	Phase 3 - rapid repolarisation
# Reactome	R-HSA-5576893	Phase 2 - plateau phase
# RecName	KCNE3_HUMAN	Potassium voltage-gated channel subfamily E member 3
# RefSeq	NP_005463	NM_005472.4
# RefSeq	XP_016872536	XM_017017047.1
# RefSeq	XP_016872537	XM_017017048.1
# RefSeq	XP_016872538	XM_017017049.1
# RefSeq	XP_016872539	XM_017017050.1
# RefSeq	XP_016872540	XM_017017051.1
# RefSeq	XP_016872541	XM_017017052.1
# SIMILARITY	Belongs to the potassium channel KCNE family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	KCNE3_HUMAN	Cell membrane {ECO 0000269|PubMed 12954870}; Single-pass type I membrane protein {ECO 0000305}. Cytoplasm {ECO 0000269|PubMed 12954870}. Perikaryon {ECO 0000269|PubMed 12954870}. Cell projection, dendrite {ECO 0000269|PubMed 12954870}. Membrane raft {ECO 0000269|PubMed 20533308}. Note=Colocalizes with KCNB1 at high-density somatodendritic clusters on the surface of hippocampal neurons. {ECO 0000269|PubMed 12954870}. 
# SUBUNIT	KCNE3_HUMAN	Interacts with KCNB1. Interacts with KCNC2 (By similarity). Associates with KCNC4/Kv3.4 (PubMed 11207363). Interacts with KCNQ1; produces a current with nearly instantaneous activation with a linear current-voltage relationship and alters membrane raft localization (By similarity) (PubMed 20533308). {ECO 0000250|UniProtKB Q9JJV7, ECO 0000269|PubMed 11207363, ECO 0000269|PubMed 20533308}. 
# TISSUE SPECIFICITY	KCNE3_HUMAN	Expressed in hippocampal neurons (at protein level) (PubMed 12954870). Widely expressed with highest levels in kidney and moderate levels in small intestine. {ECO 0000269|PubMed 10646604, ECO 0000269|PubMed 12954870}. 
# UCSC	uc001ovc	human
# eggNOG	ENOG410IZ1X	Eukaryota
# eggNOG	ENOG410XU3Y	LUCA
BLAST	swissprot:KCNE3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNE3_HUMAN
BioCyc	ZFISH:ENSG00000175538-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000175538-MONOMER
COXPRESdb	10008	http://coxpresdb.jp/data/gene/10008.shtml
CleanEx	HS_KCNE3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNE3
DOI	10.1002/humu.20834	http://dx.doi.org/10.1002/humu.20834
DOI	10.1002/jcp.22265	http://dx.doi.org/10.1002/jcp.22265
DOI	10.1016/S0092-8674(01)00207-0	http://dx.doi.org/10.1016/S0092-8674(01)00207-0
DOI	10.1038/35003200	http://dx.doi.org/10.1038/35003200
DOI	10.1074/jbc.M010713200	http://dx.doi.org/10.1074/jbc.M010713200
DOI	10.1096/fj.01-0520hyp	http://dx.doi.org/10.1096/fj.01-0520hyp
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1161/CIRCEP.107.748103	http://dx.doi.org/10.1161/CIRCEP.107.748103
DOI	10.1210/jc.2002-020698	http://dx.doi.org/10.1210/jc.2002-020698
DOI	10.1212/01.WNL.0000082392.66713.E3	http://dx.doi.org/10.1212/01.WNL.0000082392.66713.E3
DOI	10.1212/01.WNL.0000119392.29624.88	http://dx.doi.org/10.1212/01.WNL.0000119392.29624.88
EMBL	AF076531	http://www.ebi.ac.uk/ena/data/view/AF076531
EMBL	AF302494	http://www.ebi.ac.uk/ena/data/view/AF302494
EMBL	BC032235	http://www.ebi.ac.uk/ena/data/view/BC032235
Ensembl	ENST00000310128	http://www.ensembl.org/id/ENST00000310128
Ensembl	ENST00000525550	http://www.ensembl.org/id/ENST00000525550
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0031982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031982
GO_component	GO:0032809	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032809
GO_component	GO:0043204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043204
GO_component	GO:0045121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045121
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0015459	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015459
GO_process	GO:0060306	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060306
GO_process	GO:1901387	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901387
GO_process	GO:1902260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902260
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	KCNE3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNE3
GeneID	10008	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10008
GeneTree	ENSGT00390000008537	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000008537
HGNC	HGNC:6243	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6243
HOGENOM	HOG000113209	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000113209&db=HOGENOM6
HOVERGEN	HBG052228	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052228&db=HOVERGEN
HPA	HPA014849	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014849
InParanoid	Q9Y6H6	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y6H6
IntAct	Q9Y6H6	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9Y6H6*
InterPro	IPR000369	http://www.ebi.ac.uk/interpro/entry/IPR000369
InterPro	IPR005426	http://www.ebi.ac.uk/interpro/entry/IPR005426
Jabion	10008	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10008
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00215	http://www.genome.jp/dbget-bin/www_bget?H00215
KEGG_Disease	H00728	http://www.genome.jp/dbget-bin/www_bget?H00728
KEGG_Gene	hsa:10008	http://www.genome.jp/dbget-bin/www_bget?hsa:10008
KEGG_Orthology	KO:K04897	http://www.genome.jp/dbget-bin/www_bget?KO:K04897
KEGG_Pathway	ko04974	http://www.genome.jp/kegg-bin/show_pathway?ko04974
MIM	604433	http://www.ncbi.nlm.nih.gov/omim/604433
MIM	613119	http://www.ncbi.nlm.nih.gov/omim/613119
MINT	MINT-8247512	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8247512
OMA	GPGPDNQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GPGPDNQ
Orphanet	130	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=130
Orphanet	681	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=681
OrthoDB	EOG091G0Z41	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0Z41
PANTHER	PTHR15282:SF6	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15282:SF6
PDB	2NDJ	http://www.ebi.ac.uk/pdbe-srv/view/entry/2NDJ
PDBsum	2NDJ	http://www.ebi.ac.uk/pdbsum/2NDJ
PRINTS	PR00168	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00168
PRINTS	PR01606	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01606
PSORT	swissprot:KCNE3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNE3_HUMAN
PSORT-B	swissprot:KCNE3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNE3_HUMAN
PSORT2	swissprot:KCNE3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNE3_HUMAN
Pfam	PF02060	http://pfam.xfam.org/family/PF02060
PharmGKB	PA393	http://www.pharmgkb.org/do/serve?objId=PA393&objCls=Gene
Phobius	swissprot:KCNE3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNE3_HUMAN
PhylomeDB	Q9Y6H6	http://phylomedb.org/?seqid=Q9Y6H6
ProteinModelPortal	Q9Y6H6	http://www.proteinmodelportal.org/query/uniprot/Q9Y6H6
PubMed	10646604	http://www.ncbi.nlm.nih.gov/pubmed/10646604
PubMed	11104781	http://www.ncbi.nlm.nih.gov/pubmed/11104781
PubMed	11207363	http://www.ncbi.nlm.nih.gov/pubmed/11207363
PubMed	11874988	http://www.ncbi.nlm.nih.gov/pubmed/11874988
PubMed	12414843	http://www.ncbi.nlm.nih.gov/pubmed/12414843
PubMed	12954870	http://www.ncbi.nlm.nih.gov/pubmed/12954870
PubMed	14504341	http://www.ncbi.nlm.nih.gov/pubmed/14504341
PubMed	15037716	http://www.ncbi.nlm.nih.gov/pubmed/15037716
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19122847	http://www.ncbi.nlm.nih.gov/pubmed/19122847
PubMed	19306396	http://www.ncbi.nlm.nih.gov/pubmed/19306396
PubMed	20533308	http://www.ncbi.nlm.nih.gov/pubmed/20533308
Reactome	R-HSA-5576890	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576890
Reactome	R-HSA-5576893	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576893
RefSeq	NP_005463	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005463
RefSeq	XP_016872536	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016872536
RefSeq	XP_016872537	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016872537
RefSeq	XP_016872538	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016872538
RefSeq	XP_016872539	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016872539
RefSeq	XP_016872540	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016872540
RefSeq	XP_016872541	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016872541
SMR	Q9Y6H6	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9Y6H6
STRING	9606.ENSP00000310557	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000310557&targetmode=cogs
UCSC	uc001ovc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001ovc&org=rat
UniGene	Hs.523899	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.523899
UniProtKB	KCNE3_HUMAN	http://www.uniprot.org/uniprot/KCNE3_HUMAN
UniProtKB-AC	Q9Y6H6	http://www.uniprot.org/uniprot/Q9Y6H6
charge	swissprot:KCNE3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNE3_HUMAN
eggNOG	ENOG410IZ1X	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IZ1X
eggNOG	ENOG410XU3Y	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XU3Y
epestfind	swissprot:KCNE3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNE3_HUMAN
garnier	swissprot:KCNE3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNE3_HUMAN
helixturnhelix	swissprot:KCNE3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNE3_HUMAN
hmoment	swissprot:KCNE3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNE3_HUMAN
iep	swissprot:KCNE3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNE3_HUMAN
inforesidue	swissprot:KCNE3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNE3_HUMAN
neXtProt	NX_Q9Y6H6	http://www.nextprot.org/db/entry/NX_Q9Y6H6
octanol	swissprot:KCNE3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNE3_HUMAN
pepcoil	swissprot:KCNE3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNE3_HUMAN
pepdigest	swissprot:KCNE3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNE3_HUMAN
pepinfo	swissprot:KCNE3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNE3_HUMAN
pepnet	swissprot:KCNE3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNE3_HUMAN
pepstats	swissprot:KCNE3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNE3_HUMAN
pepwheel	swissprot:KCNE3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNE3_HUMAN
pepwindow	swissprot:KCNE3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNE3_HUMAN
sigcleave	swissprot:KCNE3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNE3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	NCKX6_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6J4K2-1; Sequence=Displayed; Name=2; Synonyms=S-NCLX; IsoId=Q6J4K2-2; Sequence=VSP_016996; 
# AltName	NCKX6_HUMAN	Na(+)/K(+)/Ca(2+)-exchange protein 6
# AltName	NCKX6_HUMAN	Sodium/calcium exchanger protein, mitochondrial
# AltName	NCKX6_HUMAN	Solute carrier family 24 member 6
# AltName	NCKX6_HUMAN	Solute carrier family 8 member B1
# CCDS	CCDS31909	-. [Q6J4K2-1]
# CCDS	CCDS81744	-. [Q6J4K2-2]
# ChiTaRS	SLC8B1	human
# ENZYME REGULATION	NCKX6_HUMAN	Strongly inhibited by zinc. 
# Ensembl	ENST00000202831	ENSP00000202831; ENSG00000089060. [Q6J4K2-1]
# Ensembl	ENST00000546737	ENSP00000450081; ENSG00000089060. [Q6J4K2-2]
# Ensembl	ENST00000552014	ENSP00000447091; ENSG00000089060. [Q6J4K2-1]
# ExpressionAtlas	Q6J4K2	baseline and differential
# FUNCTION	NCKX6_HUMAN	Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, thereby acting as a key regulator of mitochondrion calcium homeostasis. Regulates rates of glucose-dependent insulin secretion in pancreatic beta- cells during the first phase of insulin secretion  acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses. Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange. In contrast to other members of the family its function is independent of K(+). {ECO 0000269|PubMed 15060069, ECO 0000269|PubMed 20018762, ECO 0000269|PubMed 22829870, ECO 0000269|PubMed 23056385}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0030061	mitochondrial crista; IDA:BHF-UCL.
# GO_component	GO:0032592	integral component of mitochondrial membrane; IDA:UniProtKB.
# GO_component	GO:0042383	sarcolemma; IEA:Ensembl.
# GO_function	GO:0042803	protein homodimerization activity; IPI:BHF-UCL.
# GO_function	NCKX6_HUMAN	GO 0005432 calcium sodium antiporter activity; IDA UniProtKB.
# GO_function	NCKX6_HUMAN	GO 0015368 calcium cation antiporter activity; TAS Reactome.
# GO_function	NCKX6_HUMAN	GO 0086038 calcium sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential; TAS BHF-UCL.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006851	mitochondrial calcium ion transport; IDA:UniProtKB.
# GO_process	GO:0042593	glucose homeostasis; IDA:UniProtKB.
# GO_process	GO:0050796	regulation of insulin secretion; IDA:UniProtKB.
# GO_process	GO:0050896	response to stimulus; IEA:UniProtKB-KW.
# GO_process	GO:0051480	regulation of cytosolic calcium ion concentration; IMP:BHF-UCL.
# GO_process	GO:0051560	mitochondrial calcium ion homeostasis; IMP:BHF-UCL.
# GO_process	GO:0086036	regulation of cardiac muscle cell membrane potential; TAS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# Genevisible	Q6J4K2	HS
# HGNC	HGNC:26175	SLC8B1
# InterPro	IPR004837	NaCa_Exmemb
# KEGG_Brite	ko02001	Solute carrier family
# MIM	609841	gene
# Organism	NCKX6_HUMAN	Homo sapiens (Human)
# Pfam	PF01699	Na_Ca_ex; 2
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-425561	Sodium/Calcium exchangers
# RecName	NCKX6_HUMAN	Sodium/potassium/calcium exchanger 6, mitochondrial
# RefSeq	NP_001317395	NM_001330466.1
# RefSeq	NP_079235	NM_024959.3. [Q6J4K2-1]
# RefSeq	XP_006719670	XM_006719607.2
# RefSeq	XP_011537051	XM_011538749.2. [Q6J4K2-1]
# RefSeq	XP_011537054	XM_011538752.2
# SEQUENCE CAUTION	Sequence=BAB15271.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	NCKX6_HUMAN	Mitochondrion inner membrane {ECO 0000269|PubMed 20018762}; Multi-pass membrane protein {ECO 0000269|PubMed 20018762}. 
# TCDB	2.A.19.4:the ca(2+)	cation antiporter (caca) family
# TISSUE SPECIFICITY	Present in pancreatic beta-cells (at protein level). {ECO:0000269|PubMed	23056385}. 
# UCSC	uc001tvc	human. [Q6J4K2-1]
# eggNOG	COG0530	LUCA
# eggNOG	KOG2399	Eukaryota
BLAST	swissprot:NCKX6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NCKX6_HUMAN
COXPRESdb	80024	http://coxpresdb.jp/data/gene/80024.shtml
CleanEx	HS_SLC24A6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC24A6
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0908099107	http://dx.doi.org/10.1073/pnas.0908099107
DOI	10.1074/jbc.M401229200	http://dx.doi.org/10.1074/jbc.M401229200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1371/journal.pone.0039722	http://dx.doi.org/10.1371/journal.pone.0039722
DOI	10.1371/journal.pone.0046649	http://dx.doi.org/10.1371/journal.pone.0046649
EMBL	AC010178	http://www.ebi.ac.uk/ena/data/view/AC010178
EMBL	AK025886	http://www.ebi.ac.uk/ena/data/view/AK025886
EMBL	AY601759	http://www.ebi.ac.uk/ena/data/view/AY601759
EMBL	AY601760	http://www.ebi.ac.uk/ena/data/view/AY601760
EMBL	BC098360	http://www.ebi.ac.uk/ena/data/view/BC098360
EMBL	CH471054	http://www.ebi.ac.uk/ena/data/view/CH471054
Ensembl	ENST00000202831	http://www.ensembl.org/id/ENST00000202831
Ensembl	ENST00000546737	http://www.ensembl.org/id/ENST00000546737
Ensembl	ENST00000552014	http://www.ensembl.org/id/ENST00000552014
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0030061	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030061
GO_component	GO:0032592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032592
GO_component	GO:0042383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042383
GO_function	GO:0005432	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005432
GO_function	GO:0015368	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015368
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_function	GO:0086038	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086038
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006851	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006851
GO_process	GO:0042593	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042593
GO_process	GO:0050796	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050796
GO_process	GO:0050896	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050896
GO_process	GO:0051480	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051480
GO_process	GO:0051560	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051560
GO_process	GO:0086036	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086036
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GeneCards	SLC8B1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC8B1
GeneID	80024	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80024
GeneTree	ENSGT00760000119209	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119209
H-InvDB	HIX0171623	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0171623
HGNC	HGNC:26175	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:26175
HOGENOM	HOG000113743	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000113743&db=HOGENOM6
HOVERGEN	HBG082009	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG082009&db=HOVERGEN
HPA	HPA040668	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA040668
InParanoid	Q6J4K2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6J4K2
IntAct	Q6J4K2	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q6J4K2*
InterPro	IPR004837	http://www.ebi.ac.uk/interpro/entry/IPR004837
Jabion	80024	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=80024
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:80024	http://www.genome.jp/dbget-bin/www_bget?hsa:80024
KEGG_Orthology	KO:K13754	http://www.genome.jp/dbget-bin/www_bget?KO:K13754
MIM	609841	http://www.ncbi.nlm.nih.gov/omim/609841
OMA	ISRGHTE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ISRGHTE
OrthoDB	EOG091G05GE	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05GE
PSORT	swissprot:NCKX6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NCKX6_HUMAN
PSORT-B	swissprot:NCKX6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NCKX6_HUMAN
PSORT2	swissprot:NCKX6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NCKX6_HUMAN
Pfam	PF01699	http://pfam.xfam.org/family/PF01699
PharmGKB	PA134954965	http://www.pharmgkb.org/do/serve?objId=PA134954965&objCls=Gene
Phobius	swissprot:NCKX6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NCKX6_HUMAN
PhylomeDB	Q6J4K2	http://phylomedb.org/?seqid=Q6J4K2
ProteinModelPortal	Q6J4K2	http://www.proteinmodelportal.org/query/uniprot/Q6J4K2
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15060069	http://www.ncbi.nlm.nih.gov/pubmed/15060069
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	20018762	http://www.ncbi.nlm.nih.gov/pubmed/20018762
PubMed	22829870	http://www.ncbi.nlm.nih.gov/pubmed/22829870
PubMed	23056385	http://www.ncbi.nlm.nih.gov/pubmed/23056385
Reactome	R-HSA-425561	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425561
RefSeq	NP_001317395	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001317395
RefSeq	NP_079235	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_079235
RefSeq	XP_006719670	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006719670
RefSeq	XP_011537051	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011537051
RefSeq	XP_011537054	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011537054
STRING	9606.ENSP00000202831	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000202831&targetmode=cogs
TCDB	2.A.19.4	http://www.tcdb.org/search/result.php?tc=2.A.19.4
UCSC	uc001tvc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001tvc&org=rat
UniGene	Hs.286194	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.286194
UniProtKB	NCKX6_HUMAN	http://www.uniprot.org/uniprot/NCKX6_HUMAN
UniProtKB-AC	Q6J4K2	http://www.uniprot.org/uniprot/Q6J4K2
charge	swissprot:NCKX6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NCKX6_HUMAN
eggNOG	COG0530	http://eggnogapi.embl.de/nog_data/html/tree/COG0530
eggNOG	KOG2399	http://eggnogapi.embl.de/nog_data/html/tree/KOG2399
epestfind	swissprot:NCKX6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NCKX6_HUMAN
garnier	swissprot:NCKX6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NCKX6_HUMAN
helixturnhelix	swissprot:NCKX6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NCKX6_HUMAN
hmoment	swissprot:NCKX6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NCKX6_HUMAN
iep	swissprot:NCKX6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NCKX6_HUMAN
inforesidue	swissprot:NCKX6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NCKX6_HUMAN
neXtProt	NX_Q6J4K2	http://www.nextprot.org/db/entry/NX_Q6J4K2
octanol	swissprot:NCKX6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NCKX6_HUMAN
pepcoil	swissprot:NCKX6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NCKX6_HUMAN
pepdigest	swissprot:NCKX6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NCKX6_HUMAN
pepinfo	swissprot:NCKX6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NCKX6_HUMAN
pepnet	swissprot:NCKX6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NCKX6_HUMAN
pepstats	swissprot:NCKX6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NCKX6_HUMAN
pepwheel	swissprot:NCKX6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NCKX6_HUMAN
pepwindow	swissprot:NCKX6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NCKX6_HUMAN
sigcleave	swissprot:NCKX6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NCKX6_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCJ13_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O60928-1; Sequence=Displayed; Name=2; Synonyms=Kir7.1S; IsoId=O60928-2; Sequence=VSP_042627, VSP_042628; 
# AltName	KCJ13_HUMAN	Inward rectifier K(+) channel Kir7.1
# AltName	KCJ13_HUMAN	Potassium channel, inwardly rectifying subfamily J member 13
# CCDS	CCDS2498	-. [O60928-1]
# CCDS	CCDS54437	-. [O60928-2]
# DISEASE	KCJ13_HUMAN	Leber congenital amaurosis 16 (LCA16) [MIM 614186]  A severe dystrophy of the retina, typically becoming evident in the first years of life. Visual function is usually poor and often accompanied by nystagmus, sluggish or near-absent pupillary responses, photophobia, high hyperopia and keratoconus. {ECO 0000269|PubMed 21763485}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	KCJ13_HUMAN	Snowflake vitreoretinal degeneration (SVD) [MIM 193230]  Developmental and progressive hereditary eye disorder that affects multiple tissues within the eye. Diagnostic features of SVD include fibrillar degeneration of the vitreous humor, early-onset cataract, minute crystalline deposits in the neurosensory retina, and retinal detachment. {ECO 0000269|PubMed 18179896}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000233826	ENSP00000233826; ENSG00000115474. [O60928-1]
# Ensembl	ENST00000409779	ENSP00000386408; ENSG00000115474. [O60928-2]
# Ensembl	ENST00000410029	ENSP00000386251; ENSG00000115474. [O60928-1]
# ExpressionAtlas	O60928	baseline and differential
# FUNCTION	KCJ13_HUMAN	Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium. 
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0005242	inward rectifier potassium channel activity; NAS:UniProtKB.
# GO_process	GO:0006813	potassium ion transport; NAS:UniProtKB.
# GO_process	GO:0010107	potassium ion import; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.40.1400	-; 1.
# Genevisible	O60928	HS
# HGNC	HGNC:6259	KCNJ13
# InterPro	IPR008062	KCNJ13
# InterPro	IPR013518	K_chnl_inward-rec_Kir_cyto
# InterPro	IPR014756	Ig_E-set
# InterPro	IPR016449	K_chnl_inward-rec_Kir
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00805	[Nervous system disease; Eye disease] Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
# KEGG_Disease	H00837	[Nervous system disease; Eye disease] Leber congenital amaurosis (LCR)
# KEGG_Pathway	ko04974	Protein digestion and absorption
# MIM	193230	phenotype
# MIM	603208	gene
# MIM	614186	phenotype
# Organism	KCJ13_HUMAN	Homo sapiens (Human)
# Orphanet	65	Leber congenital amaurosis
# Orphanet	91496	Snowflake vitreoretinal degeneration
# PANTHER	PTHR11767	PTHR11767
# PANTHER	PTHR11767:SF3	PTHR11767:SF3
# PIRSF	PIRSF005465	GIRK_kir
# PRINTS	PR01320	KIRCHANNEL
# PRINTS	PR01679	KIR7CHANNEL
# PTM	KCJ13_HUMAN	Phosphorylation at Ser-201 by PKC strongly inhibits ionic currents, while phosphorylation at Ser-287 by PKA increases them. {ECO 0000269|PubMed 18976636}. 
# Pfam	PF01007	IRK
# Proteomes	UP000005640	Chromosome 2
# RecName	KCJ13_HUMAN	Inward rectifier potassium channel 13
# RefSeq	NP_001165887	NM_001172416.1. [O60928-2]
# RefSeq	NP_001165888	NM_001172417.1
# RefSeq	NP_002233	NM_002242.4. [O60928-1]
# SIMILARITY	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ13 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCJ13_HUMAN	Membrane; Multi-pass membrane protein. 
# SUPFAM	SSF81296	SSF81296
# TCDB	1.A.2.1	inward rectifier k(+) channel (irk-c) family
# TISSUE SPECIFICITY	KCJ13_HUMAN	Predominantly expressed in small intestine. Expression is also detected in stomach, kidney, and all central nervous system regions tested with the exception of spinal cord. 
# UCSC	uc002vtn	human. [O60928-1]
# eggNOG	ENOG410XQ62	LUCA
# eggNOG	KOG3827	Eukaryota
BLAST	swissprot:KCJ13_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCJ13_HUMAN
BioCyc	ZFISH:ENSG00000115474-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000115474-MONOMER
COXPRESdb	3769	http://coxpresdb.jp/data/gene/3769.shtml
CleanEx	HS_KCNJ13	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNJ13
DOI	10.1006/geno.1998.5598	http://dx.doi.org/10.1006/geno.1998.5598
DOI	10.1016/S0014-5793(98)00972-7	http://dx.doi.org/10.1016/S0014-5793(98)00972-7
DOI	10.1016/S0896-6273(00)80480-8	http://dx.doi.org/10.1016/S0896-6273(00)80480-8
DOI	10.1016/j.ajhg.2007.08.002	http://dx.doi.org/10.1016/j.ajhg.2007.08.002
DOI	10.1016/j.ajhg.2011.06.002	http://dx.doi.org/10.1016/j.ajhg.2011.06.002
DOI	10.1016/j.bbrc.2008.10.110	http://dx.doi.org/10.1016/j.bbrc.2008.10.110
DOI	10.1016/j.exer.2007.09.011	http://dx.doi.org/10.1016/j.exer.2007.09.011
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB013889	http://www.ebi.ac.uk/ena/data/view/AB013889
EMBL	AB013891	http://www.ebi.ac.uk/ena/data/view/AB013891
EMBL	AC064852	http://www.ebi.ac.uk/ena/data/view/AC064852
EMBL	AF061118	http://www.ebi.ac.uk/ena/data/view/AF061118
EMBL	AF082182	http://www.ebi.ac.uk/ena/data/view/AF082182
EMBL	AJ006128	http://www.ebi.ac.uk/ena/data/view/AJ006128
EMBL	AJ007557	http://www.ebi.ac.uk/ena/data/view/AJ007557
EMBL	AK314019	http://www.ebi.ac.uk/ena/data/view/AK314019
EMBL	AY758240	http://www.ebi.ac.uk/ena/data/view/AY758240
EMBL	AY758241	http://www.ebi.ac.uk/ena/data/view/AY758241
EMBL	BC037290	http://www.ebi.ac.uk/ena/data/view/BC037290
EMBL	CH471063	http://www.ebi.ac.uk/ena/data/view/CH471063
Ensembl	ENST00000233826	http://www.ensembl.org/id/ENST00000233826
Ensembl	ENST00000409779	http://www.ensembl.org/id/ENST00000409779
Ensembl	ENST00000410029	http://www.ensembl.org/id/ENST00000410029
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005242	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005242
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0010107	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010107
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.40.1400	http://www.cathdb.info/version/latest/superfamily/2.60.40.1400
GeneCards	KCNJ13	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNJ13
GeneID	3769	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3769
GeneTree	ENSGT00830000128392	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00830000128392
H-InvDB	HIX0002929	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0002929
HGNC	HGNC:6259	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6259
HOGENOM	HOG000237326	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237326&db=HOGENOM6
HOVERGEN	HBG006178	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006178&db=HOVERGEN
HPA	CAB033078	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB033078
InParanoid	O60928	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O60928
InterPro	IPR008062	http://www.ebi.ac.uk/interpro/entry/IPR008062
InterPro	IPR013518	http://www.ebi.ac.uk/interpro/entry/IPR013518
InterPro	IPR014756	http://www.ebi.ac.uk/interpro/entry/IPR014756
InterPro	IPR016449	http://www.ebi.ac.uk/interpro/entry/IPR016449
Jabion	3769	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3769
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00805	http://www.genome.jp/dbget-bin/www_bget?H00805
KEGG_Disease	H00837	http://www.genome.jp/dbget-bin/www_bget?H00837
KEGG_Gene	hsa:3769	http://www.genome.jp/dbget-bin/www_bget?hsa:3769
KEGG_Orthology	KO:K05006	http://www.genome.jp/dbget-bin/www_bget?KO:K05006
KEGG_Pathway	ko04974	http://www.genome.jp/kegg-bin/show_pathway?ko04974
MIM	193230	http://www.ncbi.nlm.nih.gov/omim/193230
MIM	603208	http://www.ncbi.nlm.nih.gov/omim/603208
MIM	614186	http://www.ncbi.nlm.nih.gov/omim/614186
OMA	ASFVVHW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ASFVVHW
Orphanet	65	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=65
Orphanet	91496	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=91496
OrthoDB	EOG091G0DOU	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0DOU
PANTHER	PTHR11767	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11767
PANTHER	PTHR11767:SF3	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11767:SF3
PRINTS	PR01320	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01320
PRINTS	PR01679	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01679
PSORT	swissprot:KCJ13_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCJ13_HUMAN
PSORT-B	swissprot:KCJ13_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCJ13_HUMAN
PSORT2	swissprot:KCJ13_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCJ13_HUMAN
Pfam	PF01007	http://pfam.xfam.org/family/PF01007
PharmGKB	PA30044	http://www.pharmgkb.org/do/serve?objId=PA30044&objCls=Gene
Phobius	swissprot:KCJ13_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCJ13_HUMAN
PhylomeDB	O60928	http://phylomedb.org/?seqid=O60928
ProteinModelPortal	O60928	http://www.proteinmodelportal.org/query/uniprot/O60928
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	18035352	http://www.ncbi.nlm.nih.gov/pubmed/18035352
PubMed	18179896	http://www.ncbi.nlm.nih.gov/pubmed/18179896
PubMed	18976636	http://www.ncbi.nlm.nih.gov/pubmed/18976636
PubMed	21763485	http://www.ncbi.nlm.nih.gov/pubmed/21763485
PubMed	9620703	http://www.ncbi.nlm.nih.gov/pubmed/9620703
PubMed	9738472	http://www.ncbi.nlm.nih.gov/pubmed/9738472
PubMed	9878260	http://www.ncbi.nlm.nih.gov/pubmed/9878260
RefSeq	NP_001165887	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001165887
RefSeq	NP_001165888	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001165888
RefSeq	NP_002233	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002233
SMR	O60928	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O60928
STRING	9606.ENSP00000233826	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000233826&targetmode=cogs
SUPFAM	SSF81296	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81296
TCDB	1.A.2.1	http://www.tcdb.org/search/result.php?tc=1.A.2.1
UCSC	uc002vtn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002vtn&org=rat
UniGene	Hs.467338	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.467338
UniProtKB	KCJ13_HUMAN	http://www.uniprot.org/uniprot/KCJ13_HUMAN
UniProtKB-AC	O60928	http://www.uniprot.org/uniprot/O60928
charge	swissprot:KCJ13_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCJ13_HUMAN
eggNOG	ENOG410XQ62	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ62
eggNOG	KOG3827	http://eggnogapi.embl.de/nog_data/html/tree/KOG3827
epestfind	swissprot:KCJ13_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCJ13_HUMAN
garnier	swissprot:KCJ13_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCJ13_HUMAN
helixturnhelix	swissprot:KCJ13_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCJ13_HUMAN
hmoment	swissprot:KCJ13_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCJ13_HUMAN
iep	swissprot:KCJ13_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCJ13_HUMAN
inforesidue	swissprot:KCJ13_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCJ13_HUMAN
neXtProt	NX_O60928	http://www.nextprot.org/db/entry/NX_O60928
octanol	swissprot:KCJ13_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCJ13_HUMAN
pepcoil	swissprot:KCJ13_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCJ13_HUMAN
pepdigest	swissprot:KCJ13_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCJ13_HUMAN
pepinfo	swissprot:KCJ13_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCJ13_HUMAN
pepnet	swissprot:KCJ13_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCJ13_HUMAN
pepstats	swissprot:KCJ13_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCJ13_HUMAN
pepwheel	swissprot:KCJ13_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCJ13_HUMAN
pepwindow	swissprot:KCJ13_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCJ13_HUMAN
sigcleave	swissprot:KCJ13_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCJ13_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	RYR1_HUMAN	Event=Alternative splicing; Named isoforms=3; Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=P21817-1; Sequence=Displayed; Name=2; IsoId=P21817-2; Sequence=VSP_005951; Name=3; IsoId=P21817-3; Sequence=VSP_005952; 
# AltName	RYR1_HUMAN	Skeletal muscle calcium release channel
# AltName	RYR1_HUMAN	Skeletal muscle ryanodine receptor
# AltName	RYR1_HUMAN	Skeletal muscle-type ryanodine receptor
# AltName	RYR1_HUMAN	Type 1 ryanodine receptor
# BioGrid	112173	7
# CCDS	CCDS33011	-. [P21817-1]
# CCDS	CCDS42563	-. [P21817-2]
# ChiTaRS	RYR1	human
# DISEASE	RYR1_HUMAN	Central core disease of muscle (CCD) [MIM 117000]  Autosomal dominant congenital myopathy, but a severe autosomal recessive form also exists. Both clinical and histological variability is observed. Affected individuals typically display hypotonia and proximal muscle weakness in infancy, leading to the delay of motor milestones. The clinical course of the disorder is usually slow or nonprogressive in adulthood, and the severity of the symptoms may vary from normal to significant muscle weakness. Microscopic examination of CCD-affected skeletal muscle reveals a predominance of type I fibers containing amorphous-looking areas (cores) that do not stain with oxidative and phosphorylase histochemical techniques. {ECO 0000269|PubMed 10051009, ECO 0000269|PubMed 10097181, ECO 0000269|PubMed 11113224, ECO 0000269|PubMed 11709545, ECO 0000269|PubMed 11741831, ECO 0000269|PubMed 12112081, ECO 0000269|PubMed 12136074, ECO 0000269|PubMed 12565913, ECO 0000269|PubMed 12566385, ECO 0000269|PubMed 12937085, ECO 0000269|PubMed 14670767, ECO 0000269|PubMed 14985404, ECO 0000269|PubMed 17204054, ECO 0000269|PubMed 17226826, ECO 0000269|PubMed 18253926, ECO 0000269|PubMed 18312400, ECO 0000269|PubMed 20142353, ECO 0000269|PubMed 21674524, ECO 0000269|PubMed 23558838, ECO 0000269|PubMed 24561095, ECO 0000269|PubMed 26381711, ECO 0000269|PubMed 27234031, ECO 0000269|PubMed 7829078, ECO 0000269|PubMed 8220422, ECO 0000269|PubMed 8220423, ECO 0000269|PubMed 9497245}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	RYR1_HUMAN	Malignant hyperthermia 1 (MHS1) [MIM 145600]  Autosomal dominant pharmacogenetic disorder of skeletal muscle and is one of the main causes of death due to anesthesia. In susceptible people, an MH episode can be triggered by all commonly used inhalational anesthetics such as halothane and by depolarizing muscle relaxants such as succinylcholine. The clinical features of the myopathy are hyperthermia, accelerated muscle metabolism, contractures, metabolic acidosis, tachycardia and death, if not treated with the postsynaptic muscle relaxant, dantrolene. Susceptibility to MH can be determined with the 'in vitro' contracture test (IVCT)  observing the magnitude of contractures induced in strips of muscle tissue by caffeine alone and halothane alone. Patients with normal response are MH normal (MHN), those with abnormal response to caffeine alone or halothane alone are MH equivocal (MHE(C) and MHE(H) respectively). {ECO 0000269|PubMed 10051009, ECO 0000269|PubMed 10484775, ECO 0000269|PubMed 10612851, ECO 0000269|PubMed 10823104, ECO 0000269|PubMed 10888602, ECO 0000269|PubMed 11241852, ECO 0000269|PubMed 11389482, ECO 0000269|PubMed 11525881, ECO 0000269|PubMed 11575529, ECO 0000269|PubMed 11928716, ECO 0000269|PubMed 12059893, ECO 0000269|PubMed 12066726, ECO 0000269|PubMed 12123492, ECO 0000269|PubMed 12208234, ECO 0000269|PubMed 12411788, ECO 0000269|PubMed 12709367, ECO 0000269|PubMed 12883402, ECO 0000269|PubMed 1354642, ECO 0000269|PubMed 14732627, ECO 0000269|PubMed 14985404, ECO 0000269|PubMed 15221887, ECO 0000269|PubMed 15448513, ECO 0000269|PubMed 16163667, ECO 0000269|PubMed 1774074, ECO 0000269|PubMed 19191329, ECO 0000269|PubMed 19685112, ECO 0000269|PubMed 20142353, ECO 0000269|PubMed 20681998, ECO 0000269|PubMed 23558838, ECO 0000269|PubMed 24013571, ECO 0000269|PubMed 26381711, ECO 0000269|PubMed 26631338, ECO 0000269|PubMed 7751854, ECO 0000269|PubMed 7849712, ECO 0000269|PubMed 7881417, ECO 0000269|PubMed 8012359, ECO 0000269|PubMed 9066328, ECO 0000269|PubMed 9138151, ECO 0000269|PubMed 9389851, ECO 0000269|PubMed 9450902, ECO 0000269|PubMed 9497245}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	RYR1_HUMAN	Multiminicore disease with external ophthalmoplegia (MMDO) [MIM 255320]  Clinically heterogeneous neuromuscular disorder. General features include neonatal hypotonia, delayed motor development, and generalized muscle weakness and amyotrophy, which may progress slowly or remain stable. Muscle biopsy shows multiple, poorly circumscribed, short areas of sarcomere disorganization and mitochondria depletion (areas termed minicores) in most muscle fibers. Typically, no dystrophic signs, such as muscle fiber necrosis or regeneration or significant endomysial fibrosis, are present in multiminicore disease. {ECO 0000269|PubMed 12719381, ECO 0000269|PubMed 16380615, ECO 0000269|PubMed 20583297}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	RYR1_HUMAN	Note=Defects in RYR1 may be a cause of Samaritan myopathy, a congenital myopathy with benign course. Patients display severe hypotonia and respiratory distress at birth. Unlike other congenital myopathies, the health status constantly improves and patients are minimally affected at adulthood. 
# DOMAIN	RYR1_HUMAN	The calcium release channel activity resides in the C- terminal region while the remaining part of the protein constitutes the 'foot' structure spanning the junctional gap between the sarcoplasmic reticulum (SR) and the T-tubule. {ECO 0000250}. 
# DrugBank	DB00201	Caffeine
# DrugBank	DB01219	Dantrolene
# DrugBank	DB04786	Suramin
# Ensembl	ENST00000355481	ENSP00000347667; ENSG00000196218. [P21817-2]
# Ensembl	ENST00000359596	ENSP00000352608; ENSG00000196218. [P21817-1]
# ExpressionAtlas	P21817	baseline and differential
# FUNCTION	RYR1_HUMAN	Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity). {ECO 0000250, ECO 0000269|PubMed 18268335}. 
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005790	smooth endoplasmic reticulum; TAS:ProtInc.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0005938	cell cortex; IDA:UniProtKB.
# GO_component	GO:0014701	junctional sarcoplasmic reticulum membrane; TAS:BHF-UCL.
# GO_component	GO:0014802	terminal cisterna; ISS:BHF-UCL.
# GO_component	GO:0016529	sarcoplasmic reticulum; ISS:BHF-UCL.
# GO_component	GO:0030018	Z disc; IBA:GO_Central.
# GO_component	GO:0030314	junctional membrane complex; IEA:Ensembl.
# GO_component	GO:0030315	T-tubule; IEA:Ensembl.
# GO_component	GO:0031674	I band; IDA:UniProtKB.
# GO_component	GO:0033017	sarcoplasmic reticulum membrane; ISS:UniProtKB.
# GO_component	GO:0034704	calcium channel complex; IBA:GO_Central.
# GO_component	GO:0042383	sarcolemma; IBA:GO_Central.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005219	ryanodine-sensitive calcium-release channel activity; ISS:UniProtKB.
# GO_function	GO:0005245	voltage-gated calcium channel activity; ISS:UniProtKB.
# GO_function	GO:0005262	calcium channel activity; ISS:UniProtKB.
# GO_function	GO:0005509	calcium ion binding; IBA:GO_Central.
# GO_function	GO:0005516	calmodulin binding; ISS:BHF-UCL.
# GO_function	GO:0015278	calcium-release channel activity; TAS:ProtInc.
# GO_function	GO:0048763	calcium-induced calcium release activity; IBA:GO_Central.
# GO_process	GO:0001666	response to hypoxia; IDA:BHF-UCL.
# GO_process	GO:0003151	outflow tract morphogenesis; ISS:UniProtKB.
# GO_process	GO:0006816	calcium ion transport; ISS:BHF-UCL.
# GO_process	GO:0006936	muscle contraction; ISS:UniProtKB.
# GO_process	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; ISS:UniProtKB.
# GO_process	GO:0031000	response to caffeine; ISS:BHF-UCL.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0043588	skin development; ISS:UniProtKB.
# GO_process	GO:0043931	ossification involved in bone maturation; ISS:UniProtKB.
# GO_process	GO:0048741	skeletal muscle fiber development; ISS:UniProtKB.
# GO_process	GO:0051209	release of sequestered calcium ion into cytosol; ISS:BHF-UCL.
# GO_process	GO:0051480	regulation of cytosolic calcium ion concentration; ISS:BHF-UCL.
# GO_process	GO:0071313	cellular response to caffeine; ISS:UniProtKB.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.10.238.10	-; 1.
# Gene3D	1.25.10.30	-; 2.
# Genevisible	P21817	HS
# HGNC	HGNC:10483	RYR1
# INTERACTION	RYR1_HUMAN	P54296 MYOM2; NbExp=2; IntAct=EBI-1221290, EBI-5357134; 
# IntAct	P21817	10
# InterPro	IPR000699	RIH_dom
# InterPro	IPR001870	B30.2/SPRY
# InterPro	IPR002048	EF_hand_dom
# InterPro	IPR003032	Ryanodine_rcpt
# InterPro	IPR003877	SPRY_dom
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR009460	Ryanrecept_TM4-6
# InterPro	IPR011992	EF-hand-dom_pair
# InterPro	IPR013320	ConA-like_dom
# InterPro	IPR013333	Ryan_recept
# InterPro	IPR013662	RIH_assoc-dom
# InterPro	IPR014821	Ins145_P3_rcpt
# InterPro	IPR015925	Ryanodine_recept-rel
# InterPro	IPR016093	MIR_motif
# InterPro	IPR033215	RyR1
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00699	[Musculoskeletal disease; Nervous system disease] Central core disease
# KEGG_Disease	H01310	[Musculoskeletal disease; Nervous system disease] Multicore myopathy with external ophthalmoplegia
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04713	Circadian entrainment
# KEGG_Pathway	ko04730	Long-term depression
# MIM	117000	phenotype
# MIM	145600	phenotype
# MIM	180901	gene
# MIM	255320	phenotype
# MISCELLANEOUS	Channel activity is modulated by the alkaloid ryanodine that binds to the open Ca-release channel with high affinity. At low concentrations, ryanodine maintains the channel in an open conformation. High ryanodine concentrations inhibit channel activity. Channel activity is regulated by calmodulin (CALM). The calcium release is activated by increased cytoplasmic calcium levels, by nitric oxyde (NO), caffeine and ATP. Channel activity is inhibited by magnesium ions, possibly by competition for calcium binding sites (By similarity). {ECO	0000250}. 
# MISCELLANEOUS	Coexpression of normal and mutant Thr-4898 RYR1 in a 1	1 ratio, produces RYR1 channels with normal halothane and caffeine sensitivities, but maximal levels of Ca(2+) release are reduced by 67%. Binding of [3H]ryanodine indicates that the heterozygous channel is activated by Ca(2+) concentrations 4-fold lower than normal. Single-cell analysis of cotransfected cells shows a significantly increased resting cytoplasmic Ca(2+) level and a significantly reduced luminal Ca(2+) level. These data indicated a leaky channel, possibly caused by a reduction in the Ca(2+) concentration required for channel activation. Comparison with 2 other coexpressed mutant/normal channels suggests that the Thr-4898 mutation produces one of the most abnormal RYR1 channels that has been investigated, and this level of abnormality is reflected in the severe and penetrant phenotype of affected CCD individuals. 
# Organism	RYR1_HUMAN	Homo sapiens (Human)
# Orphanet	169189	Autosomal dominant centronuclear myopathy
# Orphanet	178145	Moderate multiminicore disease with hand involvement
# Orphanet	324581	Benign Samaritan congenital myopathy
# Orphanet	423	Malignant hyperthermia
# Orphanet	597	Central core disease
# Orphanet	98905	Congenital multicore myopathy with external ophthalmoplegia
# Orphanet	99741	King-Denborough syndrome
# PANTHER	PTHR13715	PTHR13715; 6
# PANTHER	PTHR13715:SF15	PTHR13715:SF15; 6
# PIR	A35041	A35041
# PRINTS	PR00795	RYANODINER
# PROSITE	PS50188	B302_SPRY; 3
# PROSITE	PS50919	MIR; 5
# PTM	RYR1_HUMAN	Activated by reversible S-nitrosylation. Repeated very high- level exercise increases S-nitrosylation. {ECO 0000269|PubMed 11562475, ECO 0000269|PubMed 18268335}. 
# PTM	RYR1_HUMAN	Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2843 may increase channel activity. Repeated very high-level exercise increases phosphorylation at Ser-2843. {ECO 0000269|PubMed 18268335}. 
# Pfam	PF00520	Ion_trans
# Pfam	PF00622	SPRY; 3
# Pfam	PF01365	RYDR_ITPR; 2
# Pfam	PF02026	RyR; 4
# Pfam	PF02815	MIR
# Pfam	PF06459	RR_TM4-6
# Pfam	PF08454	RIH_assoc
# Pfam	PF08709	Ins145_P3_rec
# Pfam	PF13833	EF-hand_8
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# Reactome	R-HSA-5578775	Ion homeostasis
# RecName	RYR1_HUMAN	Ryanodine receptor 1
# RefSeq	NP_000531	NM_000540.2. [P21817-1]
# RefSeq	NP_001036188	NM_001042723.1. [P21817-2]
# SIMILARITY	Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR1 subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 3 B30.2/SPRY domains. {ECO:0000255|PROSITE- ProRule	PRU00548}. 
# SIMILARITY	Contains 5 MIR domains. {ECO:0000255|PROSITE- ProRule	PRU00131}. 
# SMART	SM00449	SPRY; 3
# SMART	SM00472	MIR; 4
# SUBCELLULAR LOCATION	RYR1_HUMAN	Sarcoplasmic reticulum membrane; Multi-pass membrane protein. Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. Sarcoplasmic reticulum {ECO 0000250|UniProtKB P11716}. Note=The number of predicted transmembrane domains varies between orthologs, but both N- terminus and C-terminus seem to be cytoplasmic. 
# SUBUNIT	RYR1_HUMAN	Homotetramer. Can also form heterotetramers with RYR2. Interacts with CALM; CALM with bound calcium inhibits the RYR1 channel activity. Interacts with S100A1. Interacts with FKBP1A; this stabilizes the closed conformation of the channel. Interacts with CACNA1S; interaction with CACNA1S is important for activation of the RYR1 channel. Interacts with CACNB1. Interacts with TRDN and ASPH; these interactions stimulate RYR1 channel activity (By similarity). Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1). Repeated very high-level exercise decreases interaction with PDE4D and protein phosphatase 1 (PP1). Interacts with SEPN1 (By similarity). {ECO 0000250|UniProtKB P11716, ECO 0000269|PubMed 18268335, ECO 0000269|PubMed 18650434}. 
# SUPFAM	SSF100909	SSF100909; 2
# SUPFAM	SSF47473	SSF47473
# SUPFAM	SSF49899	SSF49899; 2
# SUPFAM	SSF82109	SSF82109; 2
# TCDB	1.A.3.1	the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family
# TISSUE SPECIFICITY	Skeletal muscle and brain (cerebellum and hippocampus). {ECO:0000269|PubMed	9607712}. 
# UCSC	uc002oit	human. [P21817-1]
# WEB RESOURCE	RYR1_HUMAN	Name=Leiden Muscular Dystrophy pages Ryanodine receptor 1 (skeletal) (RYR1); Note=Leiden Open Variation Database (LOVD); URL="http //www.dmd.nl/nmdb2/home.php?select_db=RYR1";
# WEB RESOURCE	RYR1_HUMAN	Name=Wikipedia; Note=RYR1 entry; URL="http //en.wikipedia.org/wiki/RYR1"; 
# WEB RESOURCE	RYR1_HUMAN	Name=Wikipedia; Note=Ryanodine receptor entry; URL="https //en.wikipedia.org/wiki/Ryanodine_receptor"; 
# eggNOG	ENOG410YCNW	LUCA
# eggNOG	KOG2243	Eukaryota
BLAST	swissprot:RYR1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:RYR1_HUMAN
BioCyc	ZFISH:G66-31185-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31185-MONOMER
COXPRESdb	6261	http://coxpresdb.jp/data/gene/6261.shtml
CleanEx	HS_RYR1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_RYR1
DIP	DIP-29708N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29708N
DOI	10.1001/archneur.61.1.106	http://dx.doi.org/10.1001/archneur.61.1.106
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DOI	10.1093/brain/awg244	http://dx.doi.org/10.1093/brain/awg244
DOI	10.1093/hmg/10.22.2581	http://dx.doi.org/10.1093/hmg/10.22.2581
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DOI	10.1093/hmg/3.12.2181	http://dx.doi.org/10.1093/hmg/3.12.2181
DOI	10.1093/hmg/3.3.471	http://dx.doi.org/10.1093/hmg/3.3.471
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DOI	10.1111/cge.12810	http://dx.doi.org/10.1111/cge.12810
DOI	10.1111/j.1399-0004.2006.00725.x	http://dx.doi.org/10.1111/j.1399-0004.2006.00725.x
DOI	10.1111/j.1399-0004.2010.01493.x	http://dx.doi.org/10.1111/j.1399-0004.2010.01493.x
DOI	10.1111/j.1468-1331.2008.02094.x	http://dx.doi.org/10.1111/j.1468-1331.2008.02094.x
DOI	10.1136/adc.88.12.1051	http://dx.doi.org/10.1136/adc.88.12.1051
DOI	10.1136/jmg.2003.014274	http://dx.doi.org/10.1136/jmg.2003.014274
DOI	10.1136/jmg.34.4.291	http://dx.doi.org/10.1136/jmg.34.4.291
DOI	10.1212/01.wnl.0000188870.37076.f2	http://dx.doi.org/10.1212/01.wnl.0000188870.37076.f2
DOI	10.1212/WNL.55.11.1689	http://dx.doi.org/10.1212/WNL.55.11.1689
DOI	10.1212/WNL.59.2.284	http://dx.doi.org/10.1212/WNL.59.2.284
DOI	10.1213/ANE.0000000000000886	http://dx.doi.org/10.1213/ANE.0000000000000886
DOI	10.1213/ANE.0b013e3181cbd815	http://dx.doi.org/10.1213/ANE.0b013e3181cbd815
DOI	10.1213/ANE.0b013e31828a71ff	http://dx.doi.org/10.1213/ANE.0b013e31828a71ff
DOI	10.1254/jjp.88.159	http://dx.doi.org/10.1254/jjp.88.159
DOI	10.1373/49.5.761	http://dx.doi.org/10.1373/49.5.761
DrugBank	DB00201	http://www.drugbank.ca/drugs/DB00201
DrugBank	DB01219	http://www.drugbank.ca/drugs/DB01219
DrugBank	DB04786	http://www.drugbank.ca/drugs/DB04786
EMBL	AC005933	http://www.ebi.ac.uk/ena/data/view/AC005933
EMBL	AC011469	http://www.ebi.ac.uk/ena/data/view/AC011469
EMBL	AC067969	http://www.ebi.ac.uk/ena/data/view/AC067969
EMBL	J05200	http://www.ebi.ac.uk/ena/data/view/J05200
EMBL	M91455	http://www.ebi.ac.uk/ena/data/view/M91455
EMBL	S77392	http://www.ebi.ac.uk/ena/data/view/S77392
EMBL	S78717	http://www.ebi.ac.uk/ena/data/view/S78717
EMBL	U48449	http://www.ebi.ac.uk/ena/data/view/U48449
EMBL	U48450	http://www.ebi.ac.uk/ena/data/view/U48450
EMBL	U48451	http://www.ebi.ac.uk/ena/data/view/U48451
EMBL	U48452	http://www.ebi.ac.uk/ena/data/view/U48452
EMBL	U48453	http://www.ebi.ac.uk/ena/data/view/U48453
EMBL	U48454	http://www.ebi.ac.uk/ena/data/view/U48454
EMBL	U48455	http://www.ebi.ac.uk/ena/data/view/U48455
EMBL	U48456	http://www.ebi.ac.uk/ena/data/view/U48456
EMBL	U48457	http://www.ebi.ac.uk/ena/data/view/U48457
EMBL	U48458	http://www.ebi.ac.uk/ena/data/view/U48458
EMBL	U48459	http://www.ebi.ac.uk/ena/data/view/U48459
EMBL	U48460	http://www.ebi.ac.uk/ena/data/view/U48460
EMBL	U48461	http://www.ebi.ac.uk/ena/data/view/U48461
EMBL	U48462	http://www.ebi.ac.uk/ena/data/view/U48462
EMBL	U48463	http://www.ebi.ac.uk/ena/data/view/U48463
EMBL	U48464	http://www.ebi.ac.uk/ena/data/view/U48464
EMBL	U48465	http://www.ebi.ac.uk/ena/data/view/U48465
EMBL	U48466	http://www.ebi.ac.uk/ena/data/view/U48466
EMBL	U48467	http://www.ebi.ac.uk/ena/data/view/U48467
EMBL	U48468	http://www.ebi.ac.uk/ena/data/view/U48468
EMBL	U48469	http://www.ebi.ac.uk/ena/data/view/U48469
EMBL	U48470	http://www.ebi.ac.uk/ena/data/view/U48470
EMBL	U48471	http://www.ebi.ac.uk/ena/data/view/U48471
EMBL	U48472	http://www.ebi.ac.uk/ena/data/view/U48472
EMBL	U48473	http://www.ebi.ac.uk/ena/data/view/U48473
EMBL	U48474	http://www.ebi.ac.uk/ena/data/view/U48474
EMBL	U48475	http://www.ebi.ac.uk/ena/data/view/U48475
EMBL	U48476	http://www.ebi.ac.uk/ena/data/view/U48476
EMBL	U48477	http://www.ebi.ac.uk/ena/data/view/U48477
EMBL	U48478	http://www.ebi.ac.uk/ena/data/view/U48478
EMBL	U48479	http://www.ebi.ac.uk/ena/data/view/U48479
EMBL	U48480	http://www.ebi.ac.uk/ena/data/view/U48480
EMBL	U48481	http://www.ebi.ac.uk/ena/data/view/U48481
EMBL	U48482	http://www.ebi.ac.uk/ena/data/view/U48482
EMBL	U48483	http://www.ebi.ac.uk/ena/data/view/U48483
EMBL	U48484	http://www.ebi.ac.uk/ena/data/view/U48484
EMBL	U48485	http://www.ebi.ac.uk/ena/data/view/U48485
EMBL	U48486	http://www.ebi.ac.uk/ena/data/view/U48486
EMBL	U48487	http://www.ebi.ac.uk/ena/data/view/U48487
EMBL	U48488	http://www.ebi.ac.uk/ena/data/view/U48488
EMBL	U48489	http://www.ebi.ac.uk/ena/data/view/U48489
EMBL	U48490	http://www.ebi.ac.uk/ena/data/view/U48490
EMBL	U48491	http://www.ebi.ac.uk/ena/data/view/U48491
EMBL	U48492	http://www.ebi.ac.uk/ena/data/view/U48492
EMBL	U48493	http://www.ebi.ac.uk/ena/data/view/U48493
EMBL	U48494	http://www.ebi.ac.uk/ena/data/view/U48494
EMBL	U48495	http://www.ebi.ac.uk/ena/data/view/U48495
EMBL	U48496	http://www.ebi.ac.uk/ena/data/view/U48496
EMBL	U48497	http://www.ebi.ac.uk/ena/data/view/U48497
EMBL	U48498	http://www.ebi.ac.uk/ena/data/view/U48498
EMBL	U48499	http://www.ebi.ac.uk/ena/data/view/U48499
EMBL	U48500	http://www.ebi.ac.uk/ena/data/view/U48500
EMBL	U48501	http://www.ebi.ac.uk/ena/data/view/U48501
EMBL	U48502	http://www.ebi.ac.uk/ena/data/view/U48502
EMBL	U48503	http://www.ebi.ac.uk/ena/data/view/U48503
EMBL	U48504	http://www.ebi.ac.uk/ena/data/view/U48504
EMBL	U48505	http://www.ebi.ac.uk/ena/data/view/U48505
EMBL	U48506	http://www.ebi.ac.uk/ena/data/view/U48506
EMBL	U48507	http://www.ebi.ac.uk/ena/data/view/U48507
EMBL	U48508	http://www.ebi.ac.uk/ena/data/view/U48508
Ensembl	ENST00000355481	http://www.ensembl.org/id/ENST00000355481
Ensembl	ENST00000359596	http://www.ensembl.org/id/ENST00000359596
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005790
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005938	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005938
GO_component	GO:0014701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014701
GO_component	GO:0014802	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014802
GO_component	GO:0016529	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016529
GO_component	GO:0030018	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030018
GO_component	GO:0030314	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030314
GO_component	GO:0030315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030315
GO_component	GO:0031674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031674
GO_component	GO:0033017	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033017
GO_component	GO:0034704	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034704
GO_component	GO:0042383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042383
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005219
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0005516	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005516
GO_function	GO:0015278	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015278
GO_function	GO:0048763	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048763
GO_process	GO:0001666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001666
GO_process	GO:0003151	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003151
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0006936	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006936
GO_process	GO:0014808	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014808
GO_process	GO:0031000	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031000
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0043588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043588
GO_process	GO:0043931	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043931
GO_process	GO:0048741	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048741
GO_process	GO:0051209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051209
GO_process	GO:0051480	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051480
GO_process	GO:0071313	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071313
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.10.238.10	http://www.cathdb.info/version/latest/superfamily/1.10.238.10
Gene3D	1.25.10.30	http://www.cathdb.info/version/latest/superfamily/1.25.10.30
GeneCards	RYR1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=RYR1
GeneID	6261	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6261
GeneTree	ENSGT00760000119152	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119152
H-InvDB	HIX0039957	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0039957
HGNC	HGNC:10483	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10483
HOGENOM	HOG000231428	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231428&db=HOGENOM6
HOVERGEN	HBG006699	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006699&db=HOVERGEN
HPA	HPA056416	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA056416
InParanoid	P21817	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21817
IntAct	P21817	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21817*
InterPro	IPR000699	http://www.ebi.ac.uk/interpro/entry/IPR000699
InterPro	IPR001870	http://www.ebi.ac.uk/interpro/entry/IPR001870
InterPro	IPR002048	http://www.ebi.ac.uk/interpro/entry/IPR002048
InterPro	IPR003032	http://www.ebi.ac.uk/interpro/entry/IPR003032
InterPro	IPR003877	http://www.ebi.ac.uk/interpro/entry/IPR003877
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR009460	http://www.ebi.ac.uk/interpro/entry/IPR009460
InterPro	IPR011992	http://www.ebi.ac.uk/interpro/entry/IPR011992
InterPro	IPR013320	http://www.ebi.ac.uk/interpro/entry/IPR013320
InterPro	IPR013333	http://www.ebi.ac.uk/interpro/entry/IPR013333
InterPro	IPR013662	http://www.ebi.ac.uk/interpro/entry/IPR013662
InterPro	IPR014821	http://www.ebi.ac.uk/interpro/entry/IPR014821
InterPro	IPR015925	http://www.ebi.ac.uk/interpro/entry/IPR015925
InterPro	IPR016093	http://www.ebi.ac.uk/interpro/entry/IPR016093
InterPro	IPR033215	http://www.ebi.ac.uk/interpro/entry/IPR033215
Jabion	6261	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6261
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00699	http://www.genome.jp/dbget-bin/www_bget?H00699
KEGG_Disease	H01310	http://www.genome.jp/dbget-bin/www_bget?H01310
KEGG_Gene	hsa:6261	http://www.genome.jp/dbget-bin/www_bget?hsa:6261
KEGG_Orthology	KO:K04961	http://www.genome.jp/dbget-bin/www_bget?KO:K04961
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04713	http://www.genome.jp/kegg-bin/show_pathway?ko04713
KEGG_Pathway	ko04730	http://www.genome.jp/kegg-bin/show_pathway?ko04730
MIM	117000	http://www.ncbi.nlm.nih.gov/omim/117000
MIM	145600	http://www.ncbi.nlm.nih.gov/omim/145600
MIM	180901	http://www.ncbi.nlm.nih.gov/omim/180901
MIM	255320	http://www.ncbi.nlm.nih.gov/omim/255320
MINT	MINT-1605046	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1605046
OMA	WSYSAVQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WSYSAVQ
Orphanet	169189	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=169189
Orphanet	178145	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=178145
Orphanet	324581	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=324581
Orphanet	423	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=423
Orphanet	597	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=597
Orphanet	98905	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98905
Orphanet	99741	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=99741
OrthoDB	EOG091G00T0	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00T0
PANTHER	PTHR13715	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13715
PANTHER	PTHR13715:SF15	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13715:SF15
PRINTS	PR00795	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00795
PROSITE	PS50188	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50188
PROSITE	PS50919	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50919
PSORT	swissprot:RYR1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:RYR1_HUMAN
PSORT-B	swissprot:RYR1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:RYR1_HUMAN
PSORT2	swissprot:RYR1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:RYR1_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF00622	http://pfam.xfam.org/family/PF00622
Pfam	PF01365	http://pfam.xfam.org/family/PF01365
Pfam	PF02026	http://pfam.xfam.org/family/PF02026
Pfam	PF02815	http://pfam.xfam.org/family/PF02815
Pfam	PF06459	http://pfam.xfam.org/family/PF06459
Pfam	PF08454	http://pfam.xfam.org/family/PF08454
Pfam	PF08709	http://pfam.xfam.org/family/PF08709
Pfam	PF13833	http://pfam.xfam.org/family/PF13833
PharmGKB	PA34896	http://www.pharmgkb.org/do/serve?objId=PA34896&objCls=Gene
Phobius	swissprot:RYR1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:RYR1_HUMAN
PhylomeDB	P21817	http://phylomedb.org/?seqid=P21817
ProteinModelPortal	P21817	http://www.proteinmodelportal.org/query/uniprot/P21817
PubMed	10051009	http://www.ncbi.nlm.nih.gov/pubmed/10051009
PubMed	10097181	http://www.ncbi.nlm.nih.gov/pubmed/10097181
PubMed	10484775	http://www.ncbi.nlm.nih.gov/pubmed/10484775
PubMed	10612851	http://www.ncbi.nlm.nih.gov/pubmed/10612851
PubMed	10823104	http://www.ncbi.nlm.nih.gov/pubmed/10823104
PubMed	10888602	http://www.ncbi.nlm.nih.gov/pubmed/10888602
PubMed	11113224	http://www.ncbi.nlm.nih.gov/pubmed/11113224
PubMed	11241852	http://www.ncbi.nlm.nih.gov/pubmed/11241852
PubMed	11389482	http://www.ncbi.nlm.nih.gov/pubmed/11389482
PubMed	11525881	http://www.ncbi.nlm.nih.gov/pubmed/11525881
PubMed	11562475	http://www.ncbi.nlm.nih.gov/pubmed/11562475
PubMed	11575529	http://www.ncbi.nlm.nih.gov/pubmed/11575529
PubMed	11709545	http://www.ncbi.nlm.nih.gov/pubmed/11709545
PubMed	11741831	http://www.ncbi.nlm.nih.gov/pubmed/11741831
PubMed	11928716	http://www.ncbi.nlm.nih.gov/pubmed/11928716
PubMed	12059893	http://www.ncbi.nlm.nih.gov/pubmed/12059893
PubMed	12066726	http://www.ncbi.nlm.nih.gov/pubmed/12066726
PubMed	12112081	http://www.ncbi.nlm.nih.gov/pubmed/12112081
PubMed	12123492	http://www.ncbi.nlm.nih.gov/pubmed/12123492
PubMed	12136074	http://www.ncbi.nlm.nih.gov/pubmed/12136074
PubMed	12208234	http://www.ncbi.nlm.nih.gov/pubmed/12208234
PubMed	12411788	http://www.ncbi.nlm.nih.gov/pubmed/12411788
PubMed	12565913	http://www.ncbi.nlm.nih.gov/pubmed/12565913
PubMed	12566385	http://www.ncbi.nlm.nih.gov/pubmed/12566385
PubMed	12709367	http://www.ncbi.nlm.nih.gov/pubmed/12709367
PubMed	12719381	http://www.ncbi.nlm.nih.gov/pubmed/12719381
PubMed	12883402	http://www.ncbi.nlm.nih.gov/pubmed/12883402
PubMed	12937085	http://www.ncbi.nlm.nih.gov/pubmed/12937085
PubMed	1354642	http://www.ncbi.nlm.nih.gov/pubmed/1354642
PubMed	14670767	http://www.ncbi.nlm.nih.gov/pubmed/14670767
PubMed	14732627	http://www.ncbi.nlm.nih.gov/pubmed/14732627
PubMed	14985404	http://www.ncbi.nlm.nih.gov/pubmed/14985404
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	15221887	http://www.ncbi.nlm.nih.gov/pubmed/15221887
PubMed	15448513	http://www.ncbi.nlm.nih.gov/pubmed/15448513
PubMed	16163667	http://www.ncbi.nlm.nih.gov/pubmed/16163667
PubMed	16380615	http://www.ncbi.nlm.nih.gov/pubmed/16380615
PubMed	1639409	http://www.ncbi.nlm.nih.gov/pubmed/1639409
PubMed	17204054	http://www.ncbi.nlm.nih.gov/pubmed/17204054
PubMed	17226826	http://www.ncbi.nlm.nih.gov/pubmed/17226826
PubMed	1774074	http://www.ncbi.nlm.nih.gov/pubmed/1774074
PubMed	18253926	http://www.ncbi.nlm.nih.gov/pubmed/18253926
PubMed	18268335	http://www.ncbi.nlm.nih.gov/pubmed/18268335
PubMed	18312400	http://www.ncbi.nlm.nih.gov/pubmed/18312400
PubMed	18318008	http://www.ncbi.nlm.nih.gov/pubmed/18318008
PubMed	18650434	http://www.ncbi.nlm.nih.gov/pubmed/18650434
PubMed	19191329	http://www.ncbi.nlm.nih.gov/pubmed/19191329
PubMed	19685112	http://www.ncbi.nlm.nih.gov/pubmed/19685112
PubMed	20142353	http://www.ncbi.nlm.nih.gov/pubmed/20142353
PubMed	20583297	http://www.ncbi.nlm.nih.gov/pubmed/20583297
PubMed	20681998	http://www.ncbi.nlm.nih.gov/pubmed/20681998
PubMed	20961976	http://www.ncbi.nlm.nih.gov/pubmed/20961976
PubMed	21674524	http://www.ncbi.nlm.nih.gov/pubmed/21674524
PubMed	22752422	http://www.ncbi.nlm.nih.gov/pubmed/22752422
PubMed	2298749	http://www.ncbi.nlm.nih.gov/pubmed/2298749
PubMed	23558838	http://www.ncbi.nlm.nih.gov/pubmed/23558838
PubMed	24013571	http://www.ncbi.nlm.nih.gov/pubmed/24013571
PubMed	24561095	http://www.ncbi.nlm.nih.gov/pubmed/24561095
PubMed	26381711	http://www.ncbi.nlm.nih.gov/pubmed/26381711
PubMed	26631338	http://www.ncbi.nlm.nih.gov/pubmed/26631338
PubMed	27234031	http://www.ncbi.nlm.nih.gov/pubmed/27234031
PubMed	7556644	http://www.ncbi.nlm.nih.gov/pubmed/7556644
PubMed	7751854	http://www.ncbi.nlm.nih.gov/pubmed/7751854
PubMed	7829078	http://www.ncbi.nlm.nih.gov/pubmed/7829078
PubMed	7849712	http://www.ncbi.nlm.nih.gov/pubmed/7849712
PubMed	7881417	http://www.ncbi.nlm.nih.gov/pubmed/7881417
PubMed	8012359	http://www.ncbi.nlm.nih.gov/pubmed/8012359
PubMed	8220422	http://www.ncbi.nlm.nih.gov/pubmed/8220422
PubMed	8220423	http://www.ncbi.nlm.nih.gov/pubmed/8220423
PubMed	8661021	http://www.ncbi.nlm.nih.gov/pubmed/8661021
PubMed	9066328	http://www.ncbi.nlm.nih.gov/pubmed/9066328
PubMed	9138151	http://www.ncbi.nlm.nih.gov/pubmed/9138151
PubMed	9389851	http://www.ncbi.nlm.nih.gov/pubmed/9389851
PubMed	9450902	http://www.ncbi.nlm.nih.gov/pubmed/9450902
PubMed	9497245	http://www.ncbi.nlm.nih.gov/pubmed/9497245
PubMed	9607712	http://www.ncbi.nlm.nih.gov/pubmed/9607712
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
RefSeq	NP_000531	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000531
RefSeq	NP_001036188	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001036188
SMART	SM00449	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00449
SMART	SM00472	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00472
STRING	9606.ENSP00000352608	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000352608&targetmode=cogs
SUPFAM	SSF100909	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF100909
SUPFAM	SSF47473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47473
SUPFAM	SSF49899	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49899
SUPFAM	SSF82109	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82109
TCDB	1.A.3.1	http://www.tcdb.org/search/result.php?tc=1.A.3.1
UCSC	uc002oit	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002oit&org=rat
UniGene	Hs.466664	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.466664
UniProtKB	RYR1_HUMAN	http://www.uniprot.org/uniprot/RYR1_HUMAN
UniProtKB-AC	P21817	http://www.uniprot.org/uniprot/P21817
charge	swissprot:RYR1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:RYR1_HUMAN
eggNOG	ENOG410YCNW	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YCNW
eggNOG	KOG2243	http://eggnogapi.embl.de/nog_data/html/tree/KOG2243
epestfind	swissprot:RYR1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:RYR1_HUMAN
garnier	swissprot:RYR1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:RYR1_HUMAN
helixturnhelix	swissprot:RYR1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:RYR1_HUMAN
hmoment	swissprot:RYR1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:RYR1_HUMAN
iep	swissprot:RYR1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:RYR1_HUMAN
inforesidue	swissprot:RYR1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:RYR1_HUMAN
neXtProt	NX_P21817	http://www.nextprot.org/db/entry/NX_P21817
octanol	swissprot:RYR1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:RYR1_HUMAN
pepcoil	swissprot:RYR1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:RYR1_HUMAN
pepdigest	swissprot:RYR1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:RYR1_HUMAN
pepinfo	swissprot:RYR1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:RYR1_HUMAN
pepnet	swissprot:RYR1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:RYR1_HUMAN
pepstats	swissprot:RYR1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:RYR1_HUMAN
pepwheel	swissprot:RYR1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:RYR1_HUMAN
pepwindow	swissprot:RYR1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:RYR1_HUMAN
sigcleave	swissprot:RYR1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:RYR1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	NMDZ1_HUMAN	Event=Alternative splicing; Named isoforms=7; Name=3; Synonyms=Long, NR1-3; IsoId=Q05586-1; Sequence=Displayed; Name=1; Synonyms=Short, NR1-1; IsoId=Q05586-2; Sequence=VSP_000137, VSP_000138; Name=2; Synonyms=Medium, NR1-2; IsoId=Q05586-3; Sequence=VSP_000139; Name=4; IsoId=Q05586-4; Sequence=VSP_011778, VSP_011779; Name=5; IsoId=Q05586-5; Sequence=VSP_011777; Name=6; IsoId=Q05586-6; Sequence=VSP_011777, VSP_011778, VSP_011779; Name=7; IsoId=Q05586-7; Sequence=VSP_011777, VSP_045464; 
# AltName	NMDZ1_HUMAN	Glutamate [NMDA] receptor subunit zeta-1
# AltName	NMDZ1_HUMAN	N-methyl-D-aspartate receptor subunit NR1
# BioGrid	109159	11
# CCDS	CCDS43910	-. [Q05586-2]
# CCDS	CCDS55354	-. [Q05586-6]
# CCDS	CCDS55355	-. [Q05586-7]
# CCDS	CCDS7031	-. [Q05586-1]
# CCDS	CCDS7032	-. [Q05586-3]
# ChiTaRS	GRIN1	human
# DISEASE	NMDZ1_HUMAN	Mental retardation, autosomal dominant 8 (MRD8) [MIM 614254]  A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO 0000269|PubMed 21376300}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00289	Atomoxetine
# DrugBank	DB00312	Pentobarbital
# DrugBank	DB00418	Secobarbital
# DrugBank	DB00454	Pethidine
# DrugBank	DB00659	Acamprosate
# DrugBank	DB00996	Gabapentin
# DrugBank	DB01043	Memantine
# DrugBank	DB01173	Orphenadrine
# DrugBank	DB01174	Phenobarbital
# DrugBank	DB04896	Milnacipran
# DrugBank	DB06151	Acetylcysteine
# DrugBank	DB06738	Ketobemidone
# DrugBank	DB08954	Ifenprodil
# Ensembl	ENST00000371546	ENSP00000360601; ENSG00000176884. [Q05586-5]
# Ensembl	ENST00000371550	ENSP00000360605; ENSG00000176884. [Q05586-3]
# Ensembl	ENST00000371553	ENSP00000360608; ENSG00000176884. [Q05586-6]
# Ensembl	ENST00000371559	ENSP00000360614; ENSG00000176884. [Q05586-2]
# Ensembl	ENST00000371560	ENSP00000360615; ENSG00000176884. [Q05586-7]
# Ensembl	ENST00000371561	ENSP00000360616; ENSG00000176884. [Q05586-1]
# ExpressionAtlas	Q05586	baseline and differential
# FUNCTION	NMDZ1_HUMAN	NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity). {ECO 0000250}. 
# GO_component	GO:0005783	endoplasmic reticulum; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0008021	synaptic vesicle; ISS:UniProtKB.
# GO_component	GO:0009986	cell surface; ISS:BHF-UCL.
# GO_component	GO:0014069	postsynaptic density; ISS:UniProtKB.
# GO_component	GO:0017146	NMDA selective glutamate receptor complex; IDA:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030425	dendrite; IDA:UniProtKB.
# GO_component	GO:0043005	neuron projection; ISS:UniProtKB.
# GO_component	GO:0043083	synaptic cleft; ISS:BHF-UCL.
# GO_component	GO:0043195	terminal bouton; ISS:BHF-UCL.
# GO_component	GO:0043197	dendritic spine; ISS:BHF-UCL.
# GO_component	GO:0045202	synapse; ISS:UniProtKB.
# GO_component	GO:0045211	postsynaptic membrane; ISS:UniProtKB.
# GO_component	GO:0060076	excitatory synapse; ISS:BHF-UCL.
# GO_function	GO:0004972	NMDA glutamate receptor activity; IEA:Ensembl.
# GO_function	GO:0005088	Ras guanyl-nucleotide exchange factor activity; TAS:Reactome.
# GO_function	GO:0005234	extracellular-glutamate-gated ion channel activity; IEA:InterPro.
# GO_function	GO:0005262	calcium channel activity; IEA:Ensembl.
# GO_function	GO:0005509	calcium ion binding; ISS:UniProtKB.
# GO_function	GO:0005516	calmodulin binding; ISS:UniProtKB.
# GO_function	GO:0016594	glycine binding; IDA:UniProtKB.
# GO_function	GO:0016595	glutamate binding; IDA:UniProtKB.
# GO_function	GO:0042165	neurotransmitter binding; ISS:BHF-UCL.
# GO_process	GO:0000165	MAPK cascade; TAS:Reactome.
# GO_process	GO:0001661	conditioned taste aversion; IEA:Ensembl.
# GO_process	GO:0001967	suckling behavior; IEA:Ensembl.
# GO_process	GO:0001975	response to amphetamine; IEA:Ensembl.
# GO_process	GO:0006812	cation transport; IDA:UniProtKB.
# GO_process	GO:0006874	cellular calcium ion homeostasis; IEA:Ensembl.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:Reactome.
# GO_process	GO:0007585	respiratory gaseous exchange; IEA:Ensembl.
# GO_process	GO:0007616	long-term memory; IEA:Ensembl.
# GO_process	GO:0008344	adult locomotory behavior; IEA:Ensembl.
# GO_process	GO:0008355	olfactory learning; IEA:Ensembl.
# GO_process	GO:0008542	visual learning; ISS:UniProtKB.
# GO_process	GO:0018964	propylene metabolic process; ISS:BHF-UCL.
# GO_process	GO:0019233	sensory perception of pain; IEA:Ensembl.
# GO_process	GO:0021586	pons maturation; IEA:Ensembl.
# GO_process	GO:0021987	cerebral cortex development; IEA:Ensembl.
# GO_process	GO:0035176	social behavior; IEA:Ensembl.
# GO_process	GO:0035235	ionotropic glutamate receptor signaling pathway; ISS:UniProtKB.
# GO_process	GO:0035249	synaptic transmission, glutamatergic; IEA:Ensembl.
# GO_process	GO:0042391	regulation of membrane potential; IDA:UniProtKB.
# GO_process	GO:0043065	positive regulation of apoptotic process; IEA:Ensembl.
# GO_process	GO:0043278	response to morphine; IEA:Ensembl.
# GO_process	GO:0043524	negative regulation of neuron apoptotic process; IEA:Ensembl.
# GO_process	GO:0043576	regulation of respiratory gaseous exchange; IEA:Ensembl.
# GO_process	GO:0045471	response to ethanol; IDA:UniProtKB.
# GO_process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
# GO_process	GO:0048013	ephrin receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0048169	regulation of long-term neuronal synaptic plasticity; IEA:Ensembl.
# GO_process	GO:0048814	regulation of dendrite morphogenesis; IEA:Ensembl.
# GO_process	GO:0050770	regulation of axonogenesis; IEA:Ensembl.
# GO_process	GO:0051963	regulation of synapse assembly; IEA:Ensembl.
# GO_process	GO:0055074	calcium ion homeostasis; ISS:UniProtKB.
# GO_process	GO:0060079	excitatory postsynaptic potential; ISS:UniProtKB.
# GO_process	GO:0060134	prepulse inhibition; IEA:Ensembl.
# GO_process	GO:0060179	male mating behavior; IEA:Ensembl.
# GO_process	GO:2000463	positive regulation of excitatory postsynaptic potential; ISS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005576	extracellular region
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0021700	developmental maturation
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# Genevisible	Q05586	HS
# HGNC	HGNC:4584	GRIN1
# INTERACTION	NMDZ1_HUMAN	Q62936 Dlg3 (xeno); NbExp=3; IntAct=EBI-8286218, EBI-349596; 
# IntAct	Q05586	7
# InterPro	IPR001320	Iontro_rcpt
# InterPro	IPR001508	Iono_rcpt_met
# InterPro	IPR001828	ANF_lig-bd_rcpt
# InterPro	IPR018882	CaM-bd_C0_NMDA_rcpt_NR1
# InterPro	IPR019594	Glu/Gly-bd
# InterPro	IPR028082	Peripla_BP_I
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00773	[Congenital disorder; Mental retardation] Autosomal dominant mental retardation
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04713	Circadian entrainment
# KEGG_Pathway	ko04720	Long-term potentiation
# KEGG_Pathway	ko04724	Glutamatergic synapse
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05014	Amyotrophic lateral sclerosis (ALS)
# KEGG_Pathway	ko05016	Huntington's disease
# KEGG_Pathway	ko05030	Cocaine addiction
# KEGG_Pathway	ko05031	Amphetamine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# KEGG_Pathway	ko05034	Alcoholism
# MIM	138249	gene
# MIM	614254	phenotype
# Organism	NMDZ1_HUMAN	Homo sapiens (Human)
# Orphanet	178469	Autosomal dominant non-syndromic intellectual disability
# PDB	2HQW	X-ray; 1.90 A; B=875-898
# PDB	2NR1	NMR; -; A=599-621
# PDB	3BYA	X-ray; 1.85 A; B=875-898
# PDB	5H8F	X-ray; 1.81 A; B=394-544, B=663-800
# PDB	5H8H	X-ray; 2.23 A; B=394-544, B=663-800
# PDB	5H8N	X-ray; 2.50 A; B=394-544, B=663-800
# PDB	5H8Q	X-ray; 1.90 A; B=394-544, B=663-800
# PDB	5I2K	X-ray; 2.86 A; B=394-544, B=684-821
# PDB	5I2N	X-ray; 2.12 A; B=394-544, B=684-821
# PDB	5KCJ	X-ray; 2.09 A; B=394-544, B=663-800
# PDB	5KDT	X-ray; 2.44 A; B=394-544, B=684-821
# PIR	A46612	A46612
# PIR	A47551	A47551
# PRINTS	PR00177	NMDARECEPTOR
# PTM	NMDZ1_HUMAN	NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity. {ECO 0000269|PubMed 8316301}. 
# Pfam	PF00060	Lig_chan
# Pfam	PF01094	ANF_receptor
# Pfam	PF10562	CaM_bdg_C0
# Pfam	PF10613	Lig_chan-Glu_bd
# Proteomes	UP000005640	Chromosome 9
# Reactome	R-HSA-3928662	EPHB-mediated forward signaling
# Reactome	R-HSA-438066	Unblocking of NMDA receptor, glutamate binding and activation
# Reactome	R-HSA-442729	CREB phosphorylation through the activation of CaMKII
# Reactome	R-HSA-442982	Ras activation uopn Ca2+ infux through NMDA receptor
# Reactome	R-HSA-5673001	RAF/MAP kinase cascade
# Reactome	R-HSA-6794361	Interactions of neurexins and neuroligins at synapses
# Reactome	R-HSA-8849932	SALM protein interactions at the synapses
# RecName	NMDZ1_HUMAN	Glutamate receptor ionotropic, NMDA 1
# RefSeq	NP_000823	NM_000832.6. [Q05586-2]
# RefSeq	NP_001172019	NM_001185090.1. [Q05586-6]
# RefSeq	NP_001172020	NM_001185091.1. [Q05586-7]
# RefSeq	NP_015566	NM_007327.3. [Q05586-1]
# RefSeq	NP_067544	NM_021569.3. [Q05586-3]
# RefSeq	XP_005266128	XM_005266071.3. [Q05586-4]
# RefSeq	XP_005266130	XM_005266073.4. [Q05586-5]
# SIMILARITY	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily. {ECO	0000305}. 
# SMART	SM00079	PBPe
# SMART	SM00918	Lig_chan-Glu_bd
# SUBCELLULAR LOCATION	NMDZ1_HUMAN	Cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO 0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO 0000250}. Note=Enriched in postsynaptic plasma membrane and postsynaptic densities. {ECO 0000250}. 
# SUBUNIT	Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ. Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes (By similarity). Interacts with LRFN1 and LRFN2 (By similarity). Interacts with MYZAP. {ECO:0000250, ECO	0000269|PubMed:18849881}. 
# SUPFAM	SSF53822	SSF53822
# TCDB	1.A.10.1	the glutamate-gated ion channel (gic) family of neurotransmitter receptors
# UCSC	uc004clk	human. [Q05586-1]
# WEB RESOURCE	NMDZ1_HUMAN	Name=Wikipedia; Note=NMDA receptor entry; URL="https //en.wikipedia.org/wiki/NMDA_receptor";
# eggNOG	ENOG410XNUR	LUCA
# eggNOG	KOG1053	Eukaryota
BLAST	swissprot:NMDZ1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NMDZ1_HUMAN
BioCyc	ZFISH:ENSG00000176884-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000176884-MONOMER
COXPRESdb	2902	http://coxpresdb.jp/data/gene/2902.shtml
CleanEx	HS_GRIN1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GRIN1
DOI	10.1016/0378-1119(93)90309-Q	http://dx.doi.org/10.1016/0378-1119(93)90309-Q
DOI	10.1016/0378-1119(94)90089-2	http://dx.doi.org/10.1016/0378-1119(94)90089-2
DOI	10.1016/0378-1119(95)00044-7	http://dx.doi.org/10.1016/0378-1119(95)00044-7
DOI	10.1016/j.ajhg.2011.02.001	http://dx.doi.org/10.1016/j.ajhg.2011.02.001
DOI	10.1038/364070a0	http://dx.doi.org/10.1038/364070a0
DOI	10.1038/7610	http://dx.doi.org/10.1038/7610
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
DOI	10.1073/pnas.90.11.5057	http://dx.doi.org/10.1073/pnas.90.11.5057
DOI	10.1073/pnas.90.6.2174	http://dx.doi.org/10.1073/pnas.90.6.2174
DOI	10.1074/jbc.M313446200	http://dx.doi.org/10.1074/jbc.M313446200
DOI	10.1097/WNR.0b013e328317f05f	http://dx.doi.org/10.1097/WNR.0b013e328317f05f
DrugBank	DB00289	http://www.drugbank.ca/drugs/DB00289
DrugBank	DB00312	http://www.drugbank.ca/drugs/DB00312
DrugBank	DB00418	http://www.drugbank.ca/drugs/DB00418
DrugBank	DB00454	http://www.drugbank.ca/drugs/DB00454
DrugBank	DB00659	http://www.drugbank.ca/drugs/DB00659
DrugBank	DB00996	http://www.drugbank.ca/drugs/DB00996
DrugBank	DB01043	http://www.drugbank.ca/drugs/DB01043
DrugBank	DB01173	http://www.drugbank.ca/drugs/DB01173
DrugBank	DB01174	http://www.drugbank.ca/drugs/DB01174
DrugBank	DB04896	http://www.drugbank.ca/drugs/DB04896
DrugBank	DB06151	http://www.drugbank.ca/drugs/DB06151
DrugBank	DB06738	http://www.drugbank.ca/drugs/DB06738
DrugBank	DB08954	http://www.drugbank.ca/drugs/DB08954
EMBL	AF015730	http://www.ebi.ac.uk/ena/data/view/AF015730
EMBL	AF015731	http://www.ebi.ac.uk/ena/data/view/AF015731
EMBL	AL929554	http://www.ebi.ac.uk/ena/data/view/AL929554
EMBL	AL929554	http://www.ebi.ac.uk/ena/data/view/AL929554
EMBL	AL929554	http://www.ebi.ac.uk/ena/data/view/AL929554
EMBL	AL929554	http://www.ebi.ac.uk/ena/data/view/AL929554
EMBL	D13515	http://www.ebi.ac.uk/ena/data/view/D13515
EMBL	L05666	http://www.ebi.ac.uk/ena/data/view/L05666
EMBL	L13266	http://www.ebi.ac.uk/ena/data/view/L13266
EMBL	L13267	http://www.ebi.ac.uk/ena/data/view/L13267
EMBL	L13268	http://www.ebi.ac.uk/ena/data/view/L13268
EMBL	S57708	http://www.ebi.ac.uk/ena/data/view/S57708
EMBL	U08106	http://www.ebi.ac.uk/ena/data/view/U08106
EMBL	U08107	http://www.ebi.ac.uk/ena/data/view/U08107
EMBL	Z32772	http://www.ebi.ac.uk/ena/data/view/Z32772
EMBL	Z32773	http://www.ebi.ac.uk/ena/data/view/Z32773
EMBL	Z32774	http://www.ebi.ac.uk/ena/data/view/Z32774
Ensembl	ENST00000371546	http://www.ensembl.org/id/ENST00000371546
Ensembl	ENST00000371550	http://www.ensembl.org/id/ENST00000371550
Ensembl	ENST00000371553	http://www.ensembl.org/id/ENST00000371553
Ensembl	ENST00000371559	http://www.ensembl.org/id/ENST00000371559
Ensembl	ENST00000371560	http://www.ensembl.org/id/ENST00000371560
Ensembl	ENST00000371561	http://www.ensembl.org/id/ENST00000371561
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0008021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008021
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0014069	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014069
GO_component	GO:0017146	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017146
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0043005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043005
GO_component	GO:0043083	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043083
GO_component	GO:0043195	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043195
GO_component	GO:0043197	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043197
GO_component	GO:0045202	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045202
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_component	GO:0060076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060076
GO_function	GO:0004972	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004972
GO_function	GO:0005088	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005088
GO_function	GO:0005234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005234
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0005516	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005516
GO_function	GO:0016594	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016594
GO_function	GO:0016595	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016595
GO_function	GO:0042165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042165
GO_process	GO:0000165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000165
GO_process	GO:0001661	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001661
GO_process	GO:0001967	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001967
GO_process	GO:0001975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001975
GO_process	GO:0006812	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006812
GO_process	GO:0006874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007585	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007585
GO_process	GO:0007616	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007616
GO_process	GO:0008344	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008344
GO_process	GO:0008355	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008355
GO_process	GO:0008542	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008542
GO_process	GO:0018964	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018964
GO_process	GO:0019233	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019233
GO_process	GO:0021586	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021586
GO_process	GO:0021987	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021987
GO_process	GO:0035176	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035176
GO_process	GO:0035235	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035235
GO_process	GO:0035249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035249
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0043065	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043065
GO_process	GO:0043278	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043278
GO_process	GO:0043524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043524
GO_process	GO:0043576	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043576
GO_process	GO:0045471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045471
GO_process	GO:0045944	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045944
GO_process	GO:0048013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048013
GO_process	GO:0048169	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048169
GO_process	GO:0048814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048814
GO_process	GO:0050770	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050770
GO_process	GO:0051963	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051963
GO_process	GO:0055074	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055074
GO_process	GO:0060079	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060079
GO_process	GO:0060134	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060134
GO_process	GO:0060179	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060179
GO_process	GO:2000463	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000463
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005576	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0021700	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021700
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	GRIN1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GRIN1
GeneID	2902	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2902
GeneTree	ENSGT00760000119186	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119186
HGNC	HGNC:4584	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4584
HOGENOM	HOG000231491	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231491&db=HOGENOM6
HOVERGEN	HBG052638	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052638&db=HOVERGEN
HPA	CAB006831	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB006831
InParanoid	Q05586	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q05586
IntAct	Q05586	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q05586*
InterPro	IPR001320	http://www.ebi.ac.uk/interpro/entry/IPR001320
InterPro	IPR001508	http://www.ebi.ac.uk/interpro/entry/IPR001508
InterPro	IPR001828	http://www.ebi.ac.uk/interpro/entry/IPR001828
InterPro	IPR018882	http://www.ebi.ac.uk/interpro/entry/IPR018882
InterPro	IPR019594	http://www.ebi.ac.uk/interpro/entry/IPR019594
InterPro	IPR028082	http://www.ebi.ac.uk/interpro/entry/IPR028082
Jabion	2902	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2902
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00773	http://www.genome.jp/dbget-bin/www_bget?H00773
KEGG_Gene	hsa:2902	http://www.genome.jp/dbget-bin/www_bget?hsa:2902
KEGG_Orthology	KO:K05208	http://www.genome.jp/dbget-bin/www_bget?KO:K05208
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04713	http://www.genome.jp/kegg-bin/show_pathway?ko04713
KEGG_Pathway	ko04720	http://www.genome.jp/kegg-bin/show_pathway?ko04720
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05014	http://www.genome.jp/kegg-bin/show_pathway?ko05014
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
KEGG_Pathway	ko05030	http://www.genome.jp/kegg-bin/show_pathway?ko05030
KEGG_Pathway	ko05031	http://www.genome.jp/kegg-bin/show_pathway?ko05031
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
KEGG_Pathway	ko05034	http://www.genome.jp/kegg-bin/show_pathway?ko05034
MIM	138249	http://www.ncbi.nlm.nih.gov/omim/138249
MIM	614254	http://www.ncbi.nlm.nih.gov/omim/614254
MINT	MINT-1900224	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1900224
OMA	TMSDGTC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TMSDGTC
Orphanet	178469	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=178469
OrthoDB	EOG091G0M5H	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0M5H
PDB	2HQW	http://www.ebi.ac.uk/pdbe-srv/view/entry/2HQW
PDB	2NR1	http://www.ebi.ac.uk/pdbe-srv/view/entry/2NR1
PDB	3BYA	http://www.ebi.ac.uk/pdbe-srv/view/entry/3BYA
PDB	5H8F	http://www.ebi.ac.uk/pdbe-srv/view/entry/5H8F
PDB	5H8H	http://www.ebi.ac.uk/pdbe-srv/view/entry/5H8H
PDB	5H8N	http://www.ebi.ac.uk/pdbe-srv/view/entry/5H8N
PDB	5H8Q	http://www.ebi.ac.uk/pdbe-srv/view/entry/5H8Q
PDB	5I2K	http://www.ebi.ac.uk/pdbe-srv/view/entry/5I2K
PDB	5I2N	http://www.ebi.ac.uk/pdbe-srv/view/entry/5I2N
PDB	5KCJ	http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCJ
PDB	5KDT	http://www.ebi.ac.uk/pdbe-srv/view/entry/5KDT
PDBsum	2HQW	http://www.ebi.ac.uk/pdbsum/2HQW
PDBsum	2NR1	http://www.ebi.ac.uk/pdbsum/2NR1
PDBsum	3BYA	http://www.ebi.ac.uk/pdbsum/3BYA
PDBsum	5H8F	http://www.ebi.ac.uk/pdbsum/5H8F
PDBsum	5H8H	http://www.ebi.ac.uk/pdbsum/5H8H
PDBsum	5H8N	http://www.ebi.ac.uk/pdbsum/5H8N
PDBsum	5H8Q	http://www.ebi.ac.uk/pdbsum/5H8Q
PDBsum	5I2K	http://www.ebi.ac.uk/pdbsum/5I2K
PDBsum	5I2N	http://www.ebi.ac.uk/pdbsum/5I2N
PDBsum	5KCJ	http://www.ebi.ac.uk/pdbsum/5KCJ
PDBsum	5KDT	http://www.ebi.ac.uk/pdbsum/5KDT
PRINTS	PR00177	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00177
PSORT	swissprot:NMDZ1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NMDZ1_HUMAN
PSORT-B	swissprot:NMDZ1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NMDZ1_HUMAN
PSORT2	swissprot:NMDZ1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NMDZ1_HUMAN
Pfam	PF00060	http://pfam.xfam.org/family/PF00060
Pfam	PF01094	http://pfam.xfam.org/family/PF01094
Pfam	PF10562	http://pfam.xfam.org/family/PF10562
Pfam	PF10613	http://pfam.xfam.org/family/PF10613
PharmGKB	PA28978	http://www.pharmgkb.org/do/serve?objId=PA28978&objCls=Gene
Phobius	swissprot:NMDZ1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NMDZ1_HUMAN
PhylomeDB	Q05586	http://phylomedb.org/?seqid=Q05586
ProteinModelPortal	Q05586	http://www.proteinmodelportal.org/query/uniprot/Q05586
PubMed	10201407	http://www.ncbi.nlm.nih.gov/pubmed/10201407
PubMed	14732708	http://www.ncbi.nlm.nih.gov/pubmed/14732708
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
PubMed	18849881	http://www.ncbi.nlm.nih.gov/pubmed/18849881
PubMed	21376300	http://www.ncbi.nlm.nih.gov/pubmed/21376300
PubMed	7622053	http://www.ncbi.nlm.nih.gov/pubmed/7622053
PubMed	7679115	http://www.ncbi.nlm.nih.gov/pubmed/7679115
PubMed	7681588	http://www.ncbi.nlm.nih.gov/pubmed/7681588
PubMed	7685113	http://www.ncbi.nlm.nih.gov/pubmed/7685113
PubMed	7926821	http://www.ncbi.nlm.nih.gov/pubmed/7926821
PubMed	8316301	http://www.ncbi.nlm.nih.gov/pubmed/8316301
PubMed	8406025	http://www.ncbi.nlm.nih.gov/pubmed/8406025
PubMed	9231706	http://www.ncbi.nlm.nih.gov/pubmed/9231706
Reactome	R-HSA-3928662	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3928662
Reactome	R-HSA-438066	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-438066
Reactome	R-HSA-442729	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442729
Reactome	R-HSA-442982	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442982
Reactome	R-HSA-5673001	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5673001
Reactome	R-HSA-6794361	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6794361
Reactome	R-HSA-8849932	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8849932
RefSeq	NP_000823	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000823
RefSeq	NP_001172019	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001172019
RefSeq	NP_001172020	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001172020
RefSeq	NP_015566	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_015566
RefSeq	NP_067544	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_067544
RefSeq	XP_005266128	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005266128
RefSeq	XP_005266130	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005266130
SMART	SM00079	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00079
SMART	SM00918	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00918
SMR	Q05586	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q05586
STRING	9606.ENSP00000360608	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000360608&targetmode=cogs
SUPFAM	SSF53822	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822
TCDB	1.A.10.1	http://www.tcdb.org/search/result.php?tc=1.A.10.1
UCSC	uc004clk	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004clk&org=rat
UniGene	Hs.558334	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.558334
UniProtKB	NMDZ1_HUMAN	http://www.uniprot.org/uniprot/NMDZ1_HUMAN
UniProtKB-AC	Q05586	http://www.uniprot.org/uniprot/Q05586
charge	swissprot:NMDZ1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NMDZ1_HUMAN
eggNOG	ENOG410XNUR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNUR
eggNOG	KOG1053	http://eggnogapi.embl.de/nog_data/html/tree/KOG1053
epestfind	swissprot:NMDZ1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NMDZ1_HUMAN
garnier	swissprot:NMDZ1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NMDZ1_HUMAN
helixturnhelix	swissprot:NMDZ1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NMDZ1_HUMAN
hmoment	swissprot:NMDZ1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NMDZ1_HUMAN
iep	swissprot:NMDZ1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NMDZ1_HUMAN
inforesidue	swissprot:NMDZ1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NMDZ1_HUMAN
neXtProt	NX_Q05586	http://www.nextprot.org/db/entry/NX_Q05586
octanol	swissprot:NMDZ1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NMDZ1_HUMAN
pepcoil	swissprot:NMDZ1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NMDZ1_HUMAN
pepdigest	swissprot:NMDZ1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NMDZ1_HUMAN
pepinfo	swissprot:NMDZ1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NMDZ1_HUMAN
pepnet	swissprot:NMDZ1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NMDZ1_HUMAN
pepstats	swissprot:NMDZ1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NMDZ1_HUMAN
pepwheel	swissprot:NMDZ1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NMDZ1_HUMAN
pepwindow	swissprot:NMDZ1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NMDZ1_HUMAN
sigcleave	swissprot:NMDZ1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NMDZ1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S22AD_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y226-1; Sequence=Displayed; Name=2; IsoId=Q9Y226-2; Sequence=VSP_017830; 
# AltName	S22AD_HUMAN	Organic cation transporter-like 3
# BioGrid	114790	3
# CCDS	CCDS2676	-. [Q9Y226-1]
# CDD	cd06174	MFS
# Ensembl	ENST00000311856	ENSP00000310241; ENSG00000172940. [Q9Y226-1]
# ExpressionAtlas	Q9Y226	baseline and differential
# GO_component	GO:0005887	integral component of plasma membrane; NAS:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0015101	organic cation transmembrane transporter activity; NAS:UniProtKB.
# GO_function	GO:0022891	substrate-specific transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0090416	nicotinate transporter activity; IDA:UniProtKB.
# GO_process	GO:0015695	organic cation transport; NAS:UniProtKB.
# GO_process	GO:0015747	urate transport; IDA:UniProtKB.
# GO_process	GO:2001142	nicotinate transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q9Y226	HS
# HGNC	HGNC:8494	SLC22A13
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	604047	gene
# Organism	S22AD_HUMAN	Homo sapiens (Human)
# PROSITE	PS50850	MFS
# Pfam	PF00083	Sugar_tr
# Proteomes	UP000005640	Chromosome 3
# RecName	S22AD_HUMAN	Solute carrier family 22 member 13
# RefSeq	NP_004247	NM_004256.3. [Q9Y226-1]
# SIMILARITY	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S22AD_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.1.19.17	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	Ubiquitous, expressed at low levels. {ECO:0000269|PubMed	10072596}. 
# UCSC	uc003chz	human. [Q9Y226-1]
# eggNOG	ENOG410IRIC	Eukaryota
# eggNOG	ENOG410YUFN	LUCA
BLAST	swissprot:S22AD_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S22AD_HUMAN
BioCyc	ZFISH:ENSG00000172940-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000172940-MONOMER
COXPRESdb	9390	http://coxpresdb.jp/data/gene/9390.shtml
CleanEx	HS_SLC22A13	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC22A13
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/dnares/6.1.37	http://dx.doi.org/10.1093/dnares/6.1.37
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB010438	http://www.ebi.ac.uk/ena/data/view/AB010438
EMBL	AB026898	http://www.ebi.ac.uk/ena/data/view/AB026898
EMBL	AK315301	http://www.ebi.ac.uk/ena/data/view/AK315301
EMBL	BC035973	http://www.ebi.ac.uk/ena/data/view/BC035973
EMBL	CH471055	http://www.ebi.ac.uk/ena/data/view/CH471055
Ensembl	ENST00000311856	http://www.ensembl.org/id/ENST00000311856
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0015101	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015101
GO_function	GO:0022891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022891
GO_function	GO:0090416	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090416
GO_process	GO:0015695	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015695
GO_process	GO:0015747	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015747
GO_process	GO:2001142	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001142
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC22A13	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC22A13
GeneID	9390	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9390
GeneTree	ENSGT00760000118852	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118852
H-InvDB	HIX0024264	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0024264
HGNC	HGNC:8494	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:8494
HOGENOM	HOG000234569	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234569&db=HOGENOM6
HOVERGEN	HBG108433	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108433&db=HOVERGEN
HPA	HPA035603	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035603
HPA	HPA035962	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035962
InParanoid	Q9Y226	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y226
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	9390	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9390
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:9390	http://www.genome.jp/dbget-bin/www_bget?hsa:9390
KEGG_Orthology	KO:K08209	http://www.genome.jp/dbget-bin/www_bget?KO:K08209
MIM	604047	http://www.ncbi.nlm.nih.gov/omim/604047
OMA	MCIIIIF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MCIIIIF
OrthoDB	EOG091G05AC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05AC
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:S22AD_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S22AD_HUMAN
PSORT-B	swissprot:S22AD_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S22AD_HUMAN
PSORT2	swissprot:S22AD_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S22AD_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
PharmGKB	PA32814	http://www.pharmgkb.org/do/serve?objId=PA32814&objCls=Gene
Phobius	swissprot:S22AD_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S22AD_HUMAN
PhylomeDB	Q9Y226	http://phylomedb.org/?seqid=Q9Y226
ProteinModelPortal	Q9Y226	http://www.proteinmodelportal.org/query/uniprot/Q9Y226
PubMed	10072596	http://www.ncbi.nlm.nih.gov/pubmed/10072596
PubMed	10231028	http://www.ncbi.nlm.nih.gov/pubmed/10231028
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
RefSeq	NP_004247	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004247
STRING	9606.ENSP00000310241	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000310241&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.19.17	http://www.tcdb.org/search/result.php?tc=2.A.1.19.17
UCSC	uc003chz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003chz&org=rat
UniGene	Hs.225941	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.225941
UniProtKB	S22AD_HUMAN	http://www.uniprot.org/uniprot/S22AD_HUMAN
UniProtKB-AC	Q9Y226	http://www.uniprot.org/uniprot/Q9Y226
charge	swissprot:S22AD_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S22AD_HUMAN
eggNOG	ENOG410IRIC	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IRIC
eggNOG	ENOG410YUFN	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YUFN
epestfind	swissprot:S22AD_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S22AD_HUMAN
garnier	swissprot:S22AD_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S22AD_HUMAN
helixturnhelix	swissprot:S22AD_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S22AD_HUMAN
hmoment	swissprot:S22AD_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S22AD_HUMAN
iep	swissprot:S22AD_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S22AD_HUMAN
inforesidue	swissprot:S22AD_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S22AD_HUMAN
neXtProt	NX_Q9Y226	http://www.nextprot.org/db/entry/NX_Q9Y226
octanol	swissprot:S22AD_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S22AD_HUMAN
pepcoil	swissprot:S22AD_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S22AD_HUMAN
pepdigest	swissprot:S22AD_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S22AD_HUMAN
pepinfo	swissprot:S22AD_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S22AD_HUMAN
pepnet	swissprot:S22AD_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S22AD_HUMAN
pepstats	swissprot:S22AD_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S22AD_HUMAN
pepwheel	swissprot:S22AD_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S22AD_HUMAN
pepwindow	swissprot:S22AD_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S22AD_HUMAN
sigcleave	swissprot:S22AD_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S22AD_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	USO1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O60763-1; Sequence=Displayed; Name=2; IsoId=O60763-2; Sequence=VSP_039120, VSP_039121; 
# AltName	USO1_HUMAN	Protein USO1 homolog
# AltName	USO1_HUMAN	Transcytosis-associated protein
# AltName	USO1_HUMAN	Vesicle-docking protein
# BioGrid	114173	67
# CCDS	CCDS75144	-. [O60763-1]
# CCDS	CCDS77929	-. [O60763-2]
# ChiTaRS	USO1	human
# DOMAIN	USO1_HUMAN	Composed of a globular head, an elongated tail (coiled- coil) and a highly acidic C-terminal domain. {ECO 0000269|PubMed 19247479}. 
# Ensembl	ENST00000264904	ENSP00000264904; ENSG00000138768. [O60763-2]
# Ensembl	ENST00000514213	ENSP00000444850; ENSG00000138768. [O60763-1]
# ExpressionAtlas	O60763	baseline and differential
# FUNCTION	USO1_HUMAN	General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. {ECO 0000250|UniProtKB P41542}. 
# GO_component	GO:0000139	Golgi membrane; TAS:Reactome.
# GO_component	GO:0005730	nucleolus; IDA:HPA.
# GO_component	GO:0005783	endoplasmic reticulum; IBA:GO_Central.
# GO_component	GO:0005794	Golgi apparatus; IDA:HPA.
# GO_component	GO:0005795	Golgi stack; IBA:GO_Central.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0005913	cell-cell adherens junction; IDA:BHF-UCL.
# GO_component	GO:0012507	ER to Golgi transport vesicle membrane; IBA:GO_Central.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0030133	transport vesicle; TAS:Reactome.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IEA:Ensembl.
# GO_function	GO:0008565	protein transporter activity; IBA:GO_Central.
# GO_function	GO:0044822	poly(A) RNA binding; IDA:UniProtKB.
# GO_function	GO:0098641	cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
# GO_process	GO:0006886	intracellular protein transport; IBA:GO_Central.
# GO_process	GO:0006888	ER to Golgi vesicle-mediated transport; ISS:UniProtKB.
# GO_process	GO:0007030	Golgi organization; IEA:Ensembl.
# GO_process	GO:0045056	transcytosis; IBA:GO_Central.
# GO_process	GO:0048208	COPII vesicle coating; TAS:Reactome.
# GO_process	GO:0048211	Golgi vesicle docking; IBA:GO_Central.
# GO_process	GO:0048280	vesicle fusion with Golgi apparatus; IEA:InterPro.
# GO_process	GO:0061025	membrane fusion; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005730	nucleolus
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0003723	RNA binding
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0061024	membrane organization
# Genevisible	O60763	HS
# HGNC	HGNC:30904	USO1
# INTERACTION	USO1_HUMAN	Q99996-2 AKAP9; NbExp=3; IntAct=EBI-356164, EBI-9641546; Q9UNI6 DUSP12; NbExp=3; IntAct=EBI-356164, EBI-715161; Q8IUZ5 PHYKPL; NbExp=3; IntAct=EBI-356164, EBI-751947; Q9UIA9 XPO7; NbExp=3; IntAct=EBI-356164, EBI-286668; 
# IntAct	O60763	25
# InterPro	IPR000225	Armadillo
# InterPro	IPR006953	Vesicle_Uso1_P115_head
# InterPro	IPR006955	Uso1_p115_C
# InterPro	IPR016024	ARM-type_fold
# InterPro	IPR024095	Vesicle_P115-like
# MIM	603344	gene
# Organism	USO1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10013	PTHR10013
# PDB	2W3C	X-ray; 2.22 A; A=53-629
# PROSITE	PS50176	ARM_REPEAT
# PTM	USO1_HUMAN	Phosphorylated in a cell cycle-specific manner; phosphorylated in interphase but not in mitotic cells. Dephosphorylated protein associates with the Golgi membrane; phosphorylation promotes dissociation. {ECO 0000269|PubMed 9478999}. 
# Pfam	PF04869	Uso1_p115_head
# Pfam	PF04871	Uso1_p115_C
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-162658	Golgi Cisternae Pericentriolar Stack Reorganization
# Reactome	R-HSA-204005	COPII (Coat Protein 2) Mediated Vesicle Transport
# Reactome	R-HSA-6807878	COPI-mediated anterograde transport
# RecName	USO1_HUMAN	General vesicular transport factor p115
# RefSeq	NP_001276978	NM_001290049.1. [O60763-2]
# RefSeq	NP_003706	NM_003715.3. [O60763-1]
# SEQUENCE CAUTION	Sequence=AAH06398.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the VDP/USO1/EDE1 family. {ECO	0000305}. 
# SIMILARITY	Contains 12 ARM repeats. {ECO:0000255|PROSITE- ProRule	PRU00259}. 
# SMART	SM00185	ARM; 3
# SUBCELLULAR LOCATION	USO1_HUMAN	Cytoplasm, cytosol {ECO 0000269|PubMed 19454686, ECO 0000269|PubMed 9478999}. Golgi apparatus membrane {ECO 0000269|PubMed 19454686, ECO 0000269|PubMed 9478999}; Peripheral membrane protein {ECO 0000269|PubMed 19454686, ECO 0000269|PubMed 9478999}. Note=Recycles between the cytosol and the Golgi apparatus during interphase. During interphase, the phosphorylated form is found exclusively in cytosol; the unphosphorylated form is associated with Golgi apparatus membranes. {ECO 0000269|PubMed 19454686, ECO 0000269|PubMed 9478999}. 
# SUBUNIT	USO1_HUMAN	Homodimer. Dimerizes by parallel association of the tails, resulting in an elongated structure with two globular head domains side by side, and a long rod-like tail structure (Probable). Interacts with MIF. {ECO 0000269|PubMed 19247479, ECO 0000269|PubMed 19454686, ECO 0000305}. 
# SUPFAM	SSF48371	SSF48371
# UCSC	uc003hiv	human. [O60763-1]
BLAST	swissprot:USO1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:USO1_HUMAN
BioCyc	ZFISH:ENSG00000138768-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000138768-MONOMER
COXPRESdb	8615	http://coxpresdb.jp/data/gene/8615.shtml
CleanEx	HS_USO1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_USO1
DOI	10.1002/pmic.200700884	http://dx.doi.org/10.1002/pmic.200700884
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/jbc.273.9.5385	http://dx.doi.org/10.1074/jbc.273.9.5385
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1371/journal.pone.0004656	http://dx.doi.org/10.1371/journal.pone.0004656
DOI	10.4049/jimmunol.0803710	http://dx.doi.org/10.4049/jimmunol.0803710
EMBL	AC104828	http://www.ebi.ac.uk/ena/data/view/AC104828
EMBL	AC110615	http://www.ebi.ac.uk/ena/data/view/AC110615
EMBL	AK314289	http://www.ebi.ac.uk/ena/data/view/AK314289
EMBL	AL832010	http://www.ebi.ac.uk/ena/data/view/AL832010
EMBL	BC006398	http://www.ebi.ac.uk/ena/data/view/BC006398
EMBL	BC032654	http://www.ebi.ac.uk/ena/data/view/BC032654
EMBL	D86326	http://www.ebi.ac.uk/ena/data/view/D86326
Ensembl	ENST00000264904	http://www.ensembl.org/id/ENST00000264904
Ensembl	ENST00000514213	http://www.ensembl.org/id/ENST00000514213
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005730
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005795	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005795
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005913
GO_component	GO:0012507	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0012507
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0030133	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030133
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0044822	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044822
GO_function	GO:0098641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098641
GO_process	GO:0006886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006886
GO_process	GO:0006888	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006888
GO_process	GO:0007030	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007030
GO_process	GO:0045056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045056
GO_process	GO:0048208	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048208
GO_process	GO:0048211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048211
GO_process	GO:0048280	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048280
GO_process	GO:0061025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061025
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005730
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0003723	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
GeneCards	USO1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=USO1
GeneID	8615	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8615
GeneTree	ENSGT00390000017018	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000017018
HGNC	HGNC:30904	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:30904
HOGENOM	HOG000016409	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000016409&db=HOGENOM6
HOVERGEN	HBG018067	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG018067&db=HOVERGEN
HPA	CAB010108	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB010108
HPA	HPA038282	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA038282
HPA	HPA038283	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA038283
InParanoid	O60763	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O60763
IntAct	O60763	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O60763*
InterPro	IPR000225	http://www.ebi.ac.uk/interpro/entry/IPR000225
InterPro	IPR006953	http://www.ebi.ac.uk/interpro/entry/IPR006953
InterPro	IPR006955	http://www.ebi.ac.uk/interpro/entry/IPR006955
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
InterPro	IPR024095	http://www.ebi.ac.uk/interpro/entry/IPR024095
Jabion	8615	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=8615
KEGG_Gene	hsa:8615	http://www.genome.jp/dbget-bin/www_bget?hsa:8615
MIM	603344	http://www.ncbi.nlm.nih.gov/omim/603344
MINT	MINT-1136055	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1136055
OMA	GYQVNQD	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GYQVNQD
OrthoDB	EOG091G046H	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G046H
PANTHER	PTHR10013	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10013
PDB	2W3C	http://www.ebi.ac.uk/pdbe-srv/view/entry/2W3C
PDBsum	2W3C	http://www.ebi.ac.uk/pdbsum/2W3C
PROSITE	PS50176	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50176
PSORT	swissprot:USO1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:USO1_HUMAN
PSORT-B	swissprot:USO1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:USO1_HUMAN
PSORT2	swissprot:USO1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:USO1_HUMAN
Pfam	PF04869	http://pfam.xfam.org/family/PF04869
Pfam	PF04871	http://pfam.xfam.org/family/PF04871
PharmGKB	PA162408713	http://www.pharmgkb.org/do/serve?objId=PA162408713&objCls=Gene
Phobius	swissprot:USO1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:USO1_HUMAN
PhylomeDB	O60763	http://phylomedb.org/?seqid=O60763
ProteinModelPortal	O60763	http://www.proteinmodelportal.org/query/uniprot/O60763
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18318008	http://www.ncbi.nlm.nih.gov/pubmed/18318008
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19247479	http://www.ncbi.nlm.nih.gov/pubmed/19247479
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19454686	http://www.ncbi.nlm.nih.gov/pubmed/19454686
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	9478999	http://www.ncbi.nlm.nih.gov/pubmed/9478999
Reactome	R-HSA-162658	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-162658
Reactome	R-HSA-204005	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-204005
Reactome	R-HSA-6807878	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6807878
RefSeq	NP_001276978	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001276978
RefSeq	NP_003706	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003706
SMART	SM00185	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00185
SMR	O60763	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O60763
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
UCSC	uc003hiv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003hiv&org=rat
UniGene	Hs.744877	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.744877
UniProtKB	USO1_HUMAN	http://www.uniprot.org/uniprot/USO1_HUMAN
UniProtKB-AC	O60763	http://www.uniprot.org/uniprot/O60763
charge	swissprot:USO1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:USO1_HUMAN
epestfind	swissprot:USO1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:USO1_HUMAN
garnier	swissprot:USO1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:USO1_HUMAN
helixturnhelix	swissprot:USO1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:USO1_HUMAN
hmoment	swissprot:USO1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:USO1_HUMAN
iep	swissprot:USO1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:USO1_HUMAN
inforesidue	swissprot:USO1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:USO1_HUMAN
neXtProt	NX_O60763	http://www.nextprot.org/db/entry/NX_O60763
octanol	swissprot:USO1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:USO1_HUMAN
pepcoil	swissprot:USO1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:USO1_HUMAN
pepdigest	swissprot:USO1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:USO1_HUMAN
pepinfo	swissprot:USO1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:USO1_HUMAN
pepnet	swissprot:USO1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:USO1_HUMAN
pepstats	swissprot:USO1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:USO1_HUMAN
pepwheel	swissprot:USO1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:USO1_HUMAN
pepwindow	swissprot:USO1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:USO1_HUMAN
sigcleave	swissprot:USO1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:USO1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ANO6_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q4KMQ2-1; Sequence=Displayed; Name=2; IsoId=Q4KMQ2-2; Sequence=VSP_042893; Note=No experimental confirmation available.; Name=3; IsoId=Q4KMQ2-3; Sequence=VSP_046819; Note=Gene prediction based on EST data.; Name=4; IsoId=Q4KMQ2-4; Sequence=VSP_046820; Note=Gene prediction based on EST data.; 
# AltName	ANO6_HUMAN	Small-conductance calcium-activated nonselective cation channel
# AltName	ANO6_HUMAN	Transmembrane protein 16F
# BioGrid	128218	28
# CCDS	CCDS31782	-. [Q4KMQ2-1]
# CCDS	CCDS44865	-. [Q4KMQ2-4]
# CCDS	CCDS44866	-. [Q4KMQ2-3]
# CCDS	CCDS55819	-. [Q4KMQ2-2]
# ChiTaRS	ANO6	human
# DISEASE	ANO6_HUMAN	Scott syndrome (SCTS) [MIM 262890]  A mild bleeding disorder due to impaired surface exposure of procoagulant phosphatidylserine (PS) on platelets and other blood cells, following activation with Ca(2+)-elevating agents. {ECO 0000269|PubMed 21107324}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# ENZYME REGULATION	Exhibits synergistic gating by Ca(2+) and voltage. Inhibited by some non-specific cation channel blockers such as: ruthenium red, 2-aminoethyl diphenylborinate (2APB), gadolinium and cadmium ions (By similarity). {ECO	0000250}. 
# Ensembl	ENST00000320560	ENSP00000320087; ENSG00000177119. [Q4KMQ2-1]
# Ensembl	ENST00000423947	ENSP00000409126; ENSG00000177119. [Q4KMQ2-2]
# Ensembl	ENST00000425752	ENSP00000391417; ENSG00000177119. [Q4KMQ2-4]
# Ensembl	ENST00000441606	ENSP00000413137; ENSG00000177119. [Q4KMQ2-3]
# ExpressionAtlas	Q4KMQ2	baseline and differential
# FUNCTION	ANO6_HUMAN	Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes. {ECO 0000250|UniProtKB Q6P9J9, ECO 0000269|PubMed 20056604, ECO 0000269|PubMed 21107324, ECO 0000269|PubMed 21908539, ECO 0000269|PubMed 22006324, ECO 0000269|PubMed 22946059}. 
# GO_component	GO:0005622	intracellular; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0009986	cell surface; IDA:UniProtKB.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0034707	chloride channel complex; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005227	calcium activated cation channel activity; IDA:UniProtKB.
# GO_function	GO:0005229	intracellular calcium activated chloride channel activity; IMP:UniProtKB.
# GO_function	GO:0005244	voltage-gated ion channel activity; ISS:UniProtKB.
# GO_function	GO:0005247	voltage-gated chloride channel activity; IMP:UniProtKB.
# GO_function	GO:0017128	phospholipid scramblase activity; IEA:Ensembl.
# GO_process	GO:0002407	dendritic cell chemotaxis; IEA:Ensembl.
# GO_process	GO:0002543	activation of blood coagulation via clotting cascade; IMP:UniProtKB.
# GO_process	GO:0006812	cation transport; IDA:UniProtKB.
# GO_process	GO:0006821	chloride transport; IMP:UniProtKB.
# GO_process	GO:0007596	blood coagulation; ISS:UniProtKB.
# GO_process	GO:0017121	phospholipid scrambling; IMP:UniProtKB.
# GO_process	GO:0030501	positive regulation of bone mineralization; IMP:UniProtKB.
# GO_process	GO:0032060	bleb assembly; IMP:UniProtKB.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0034767	positive regulation of ion transmembrane transport; IMP:UniProtKB.
# GO_process	GO:0035590	purinergic nucleotide receptor signaling pathway; IMP:UniProtKB.
# GO_process	GO:0035630	bone mineralization involved in bone maturation; IEA:Ensembl.
# GO_process	GO:0035725	sodium ion transmembrane transport; IGI:UniProtKB.
# GO_process	GO:0043065	positive regulation of apoptotic process; ISS:UniProtKB.
# GO_process	GO:0045794	negative regulation of cell volume; IMP:UniProtKB.
# GO_process	GO:0046931	pore complex assembly; IMP:UniProtKB.
# GO_process	GO:0060100	positive regulation of phagocytosis, engulfment; ISS:UniProtKB.
# GO_process	GO:0061589	calcium activated phosphatidylserine scrambling; IEA:Ensembl.
# GO_process	GO:0061590	calcium activated phosphatidylcholine scrambling; IEA:Ensembl.
# GO_process	GO:0061591	calcium activated galactosylceramide scrambling; IEA:Ensembl.
# GO_process	GO:0070588	calcium ion transmembrane transport; IGI:UniProtKB.
# GO_process	GO:0090026	positive regulation of monocyte chemotaxis; IMP:UniProtKB.
# GO_process	GO:0097045	phosphatidylserine exposure on blood platelet; IMP:UniProtKB.
# GO_process	GO:1902304	positive regulation of potassium ion export; ISS:BHF-UCL.
# GO_process	GO:1902476	chloride transmembrane transport; IGI:UniProtKB.
# GO_process	GO:2000353	positive regulation of endothelial cell apoptotic process; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005622	intracellular
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007009	plasma membrane organization
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0022607	cellular component assembly
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0048870	cell motility
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q4KMQ2	HS
# HGNC	HGNC:25240	ANO6
# IntAct	Q4KMQ2	6
# InterPro	IPR007632	Anoctamin
# InterPro	IPR031295	Anoctamin-6
# InterPro	IPR032394	Anoct_dimer
# KEGG_Disease	H01162	[Hematologic disease] Scott syndrome
# MIM	262890	phenotype
# MIM	608663	gene
# MISCELLANEOUS	ANO6_HUMAN	The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology. 
# Organism	ANO6_HUMAN	Homo sapiens (Human)
# Orphanet	806	Scott syndrome
# PANTHER	PTHR12308	PTHR12308
# PANTHER	PTHR12308:SF21	PTHR12308:SF21
# Pfam	PF04547	Anoctamin
# Pfam	PF16178	Anoct_dimer
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# Reactome	R-HSA-6798695	Neutrophil degranulation
# RecName	ANO6_HUMAN	Anoctamin-6
# RefSeq	NP_001020527	NM_001025356.2. [Q4KMQ2-1]
# RefSeq	NP_001136150	NM_001142678.1. [Q4KMQ2-3]
# RefSeq	NP_001136151	NM_001142679.1. [Q4KMQ2-4]
# RefSeq	NP_001191732	NM_001204803.1. [Q4KMQ2-2]
# SIMILARITY	Belongs to the anoctamin family. {ECO	0000305}.
# SUBCELLULAR LOCATION	ANO6_HUMAN	Cell membrane {ECO 0000269|PubMed 20056604, ECO 0000269|PubMed 21107324, ECO 0000269|PubMed 22075693, ECO 0000269|PubMed 22946059}; Multi-pass membrane protein {ECO 0000269|PubMed 20056604, ECO 0000269|PubMed 21107324, ECO 0000269|PubMed 22075693, ECO 0000269|PubMed 22946059}. Note=Shows an intracellular localization according to PubMed 22075693. 
# TCDB	1.A.17.1	the calcium-dependent chloride channel (ca-clc) family
# TISSUE SPECIFICITY	Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and intestinal cancer. {ECO:0000269|PubMed	15067359}. 
# UCSC	uc001roo	human. [Q4KMQ2-1]
# eggNOG	ENOG410XS4S	LUCA
# eggNOG	KOG2514	Eukaryota
BLAST	swissprot:ANO6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ANO6_HUMAN
COXPRESdb	196527	http://coxpresdb.jp/data/gene/196527.shtml
CleanEx	HS_ANO6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ANO6
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1007/s00424-011-0975-9	http://dx.doi.org/10.1007/s00424-011-0975-9
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/aps.2011.48	http://dx.doi.org/10.1038/aps.2011.48
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1038/nature09583	http://dx.doi.org/10.1038/nature09583
DOI	10.1073/pnas.1108094108	http://dx.doi.org/10.1073/pnas.1108094108
DOI	10.1074/jbc.M109.065367	http://dx.doi.org/10.1074/jbc.M109.065367
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1113/expphysiol.2011.058198	http://dx.doi.org/10.1113/expphysiol.2011.058198
DOI	10.1113/expphysiol.2011.058206	http://dx.doi.org/10.1113/expphysiol.2011.058206
DOI	10.1113/expphysiol.2011.058214	http://dx.doi.org/10.1113/expphysiol.2011.058214
DOI	10.1152/ajpcell.00140.2011	http://dx.doi.org/10.1152/ajpcell.00140.2011
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.1242/jcs.109553	http://dx.doi.org/10.1242/jcs.109553
EMBL	AC009248	http://www.ebi.ac.uk/ena/data/view/AC009248
EMBL	AC009778	http://www.ebi.ac.uk/ena/data/view/AC009778
EMBL	AC063924	http://www.ebi.ac.uk/ena/data/view/AC063924
EMBL	AL833405	http://www.ebi.ac.uk/ena/data/view/AL833405
EMBL	BC098410	http://www.ebi.ac.uk/ena/data/view/BC098410
EMBL	BC136445	http://www.ebi.ac.uk/ena/data/view/BC136445
Ensembl	ENST00000320560	http://www.ensembl.org/id/ENST00000320560
Ensembl	ENST00000423947	http://www.ensembl.org/id/ENST00000423947
Ensembl	ENST00000425752	http://www.ensembl.org/id/ENST00000425752
Ensembl	ENST00000441606	http://www.ensembl.org/id/ENST00000441606
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005227	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005227
GO_function	GO:0005229	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005229
GO_function	GO:0005244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005244
GO_function	GO:0005247	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005247
GO_function	GO:0017128	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017128
GO_process	GO:0002407	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002407
GO_process	GO:0002543	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002543
GO_process	GO:0006812	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006812
GO_process	GO:0006821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006821
GO_process	GO:0007596	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007596
GO_process	GO:0017121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017121
GO_process	GO:0030501	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030501
GO_process	GO:0032060	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032060
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0034767	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034767
GO_process	GO:0035590	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035590
GO_process	GO:0035630	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035630
GO_process	GO:0035725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035725
GO_process	GO:0043065	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043065
GO_process	GO:0045794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045794
GO_process	GO:0046931	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046931
GO_process	GO:0060100	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060100
GO_process	GO:0061589	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061589
GO_process	GO:0061590	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061590
GO_process	GO:0061591	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061591
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:0090026	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090026
GO_process	GO:0097045	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097045
GO_process	GO:1902304	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902304
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GO_process	GO:2000353	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000353
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007009
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0022607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ANO6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ANO6
GeneID	196527	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=196527
GeneTree	ENSGT00760000119015	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119015
H-InvDB	HIX0010565	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0010565
HGNC	HGNC:25240	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:25240
HOGENOM	HOG000006509	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006509&db=HOGENOM6
HOVERGEN	HBG069519	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG069519&db=HOVERGEN
HPA	HPA038958	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA038958
InParanoid	Q4KMQ2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q4KMQ2
IntAct	Q4KMQ2	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q4KMQ2*
InterPro	IPR007632	http://www.ebi.ac.uk/interpro/entry/IPR007632
InterPro	IPR031295	http://www.ebi.ac.uk/interpro/entry/IPR031295
InterPro	IPR032394	http://www.ebi.ac.uk/interpro/entry/IPR032394
Jabion	196527	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=196527
KEGG_Disease	H01162	http://www.genome.jp/dbget-bin/www_bget?H01162
KEGG_Gene	hsa:196527	http://www.genome.jp/dbget-bin/www_bget?hsa:196527
MIM	262890	http://www.ncbi.nlm.nih.gov/omim/262890
MIM	608663	http://www.ncbi.nlm.nih.gov/omim/608663
MINT	MINT-5001391	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5001391
OMA	KHNIYYW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KHNIYYW
Orphanet	806	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=806
OrthoDB	EOG091G01JF	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01JF
PANTHER	PTHR12308	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12308
PANTHER	PTHR12308:SF21	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12308:SF21
PSORT	swissprot:ANO6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ANO6_HUMAN
PSORT-B	swissprot:ANO6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ANO6_HUMAN
PSORT2	swissprot:ANO6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ANO6_HUMAN
Pfam	PF04547	http://pfam.xfam.org/family/PF04547
Pfam	PF16178	http://pfam.xfam.org/family/PF16178
PharmGKB	PA164715690	http://www.pharmgkb.org/do/serve?objId=PA164715690&objCls=Gene
Phobius	swissprot:ANO6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ANO6_HUMAN
PhylomeDB	Q4KMQ2	http://phylomedb.org/?seqid=Q4KMQ2
ProteinModelPortal	Q4KMQ2	http://www.proteinmodelportal.org/query/uniprot/Q4KMQ2
PubMed	15067359	http://www.ncbi.nlm.nih.gov/pubmed/15067359
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	20056604	http://www.ncbi.nlm.nih.gov/pubmed/20056604
PubMed	21107324	http://www.ncbi.nlm.nih.gov/pubmed/21107324
PubMed	21607626	http://www.ncbi.nlm.nih.gov/pubmed/21607626
PubMed	21642943	http://www.ncbi.nlm.nih.gov/pubmed/21642943
PubMed	21908539	http://www.ncbi.nlm.nih.gov/pubmed/21908539
PubMed	21984732	http://www.ncbi.nlm.nih.gov/pubmed/21984732
PubMed	22006324	http://www.ncbi.nlm.nih.gov/pubmed/22006324
PubMed	22075693	http://www.ncbi.nlm.nih.gov/pubmed/22075693
PubMed	22302790	http://www.ncbi.nlm.nih.gov/pubmed/22302790
PubMed	22946059	http://www.ncbi.nlm.nih.gov/pubmed/22946059
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
Reactome	R-HSA-6798695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6798695
RefSeq	NP_001020527	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001020527
RefSeq	NP_001136150	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001136150
RefSeq	NP_001136151	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001136151
RefSeq	NP_001191732	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001191732
STRING	9606.ENSP00000409126	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000409126&targetmode=cogs
TCDB	1.A.17.1	http://www.tcdb.org/search/result.php?tc=1.A.17.1
UCSC	uc001roo	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001roo&org=rat
UniGene	Hs.505339	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.505339
UniProtKB	ANO6_HUMAN	http://www.uniprot.org/uniprot/ANO6_HUMAN
UniProtKB-AC	Q4KMQ2	http://www.uniprot.org/uniprot/Q4KMQ2
charge	swissprot:ANO6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ANO6_HUMAN
eggNOG	ENOG410XS4S	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS4S
eggNOG	KOG2514	http://eggnogapi.embl.de/nog_data/html/tree/KOG2514
epestfind	swissprot:ANO6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ANO6_HUMAN
garnier	swissprot:ANO6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ANO6_HUMAN
helixturnhelix	swissprot:ANO6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ANO6_HUMAN
hmoment	swissprot:ANO6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ANO6_HUMAN
iep	swissprot:ANO6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ANO6_HUMAN
inforesidue	swissprot:ANO6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ANO6_HUMAN
neXtProt	NX_Q4KMQ2	http://www.nextprot.org/db/entry/NX_Q4KMQ2
octanol	swissprot:ANO6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ANO6_HUMAN
pepcoil	swissprot:ANO6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ANO6_HUMAN
pepdigest	swissprot:ANO6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ANO6_HUMAN
pepinfo	swissprot:ANO6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ANO6_HUMAN
pepnet	swissprot:ANO6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ANO6_HUMAN
pepstats	swissprot:ANO6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ANO6_HUMAN
pepwheel	swissprot:ANO6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ANO6_HUMAN
pepwindow	swissprot:ANO6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ANO6_HUMAN
sigcleave	swissprot:ANO6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ANO6_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S29A3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BZD2-1; Sequence=Displayed; Name=2; IsoId=Q9BZD2-2; Sequence=VSP_037436; Note=No experimental confirmation available.; 
# AltName	S29A3_HUMAN	Solute carrier family 29 member 3
# BIOPHYSICOCHEMICAL PROPERTIES	S29A3_HUMAN	Kinetic parameters  KM=1.86 mM for adenosine {ECO 0000269|PubMed 15701636}; KM=2.02 mM for uridine {ECO 0000269|PubMed 15701636}; pH dependence  Optimum pH is 5.5 for adenosine uptake. {ECO 0000269|PubMed 15701636}; 
# CCDS	CCDS7310	-. [Q9BZD2-1]
# ChiTaRS	SLC29A3	human
# DISEASE	S29A3_HUMAN	Histiocytosis-lymphadenopathy plus syndrome (HLAS) [MIM 602782]  A syndrome characterized by the combination of features from 2 or more of four histiocytic disorders, originally thought to be distinct  Faisalabad histiocytosis (FHC), sinus histiocytosis with massive lymphadenopathy (SHML), H syndrome, and pigmented hypertrichosis with insulin-dependent diabetes mellitus syndrome (PHID). FHC features include joint deformities, sensorineural hearing loss, and subsequent development of generalized lymphadenopathy and swellings in the eyelids that contain histiocytes. SHML causes lymph node enlargement in children frequently accompanied by fever, leukocytosis, elevated erythrocyte sedimentation rate, and polyclonal hypergammaglobulinemia. H syndrome is characterized by cutaneous hyperpigmentation and hypertrichosis, hepatosplenomegaly, heart anomalies, and hypogonadism; hearing loss is found in about half of patients. PHID is characterized by predominantly antibody- negative insulin-dependent diabetes mellitus associated with pigmented hypertrichosis and variable occurrence of other features of H syndrome. {ECO 0000269|PubMed 18940313, ECO 0000269|PubMed 19336477, ECO 0000269|PubMed 19889517, ECO 0000269|PubMed 20140240, ECO 0000269|PubMed 20199539, ECO 0000269|PubMed 20399510, ECO 0000269|PubMed 20619369, ECO 0000269|PubMed 21888995}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000373189	ENSP00000362285; ENSG00000198246. [Q9BZD2-1]
# FUNCTION	S29A3_HUMAN	Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine, as well as several nucleoside analog drugs, such as anticancer and antiviral agents, including cladribine, cordycepin, tubercidin and AZT. Does not transport hypoxanthine. {ECO 0000269|PubMed 15701636}. 
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0031902	late endosome membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0005337	nucleoside transmembrane transporter activity; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# Genevisible	Q9BZD2	HS
# HGNC	HGNC:23096	SLC29A3
# InterPro	IPR002259	Eqnu_transpt
# InterPro	IPR030193	ENT3
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H00815	[Developmental disorder] H syndrome
# MIM	602782	phenotype
# MIM	612373	gene
# Organism	S29A3_HUMAN	Homo sapiens (Human)
# Orphanet	168569	H syndrome
# Orphanet	1782	Dysosteosclerosis
# PANTHER	PTHR10332	PTHR10332
# PANTHER	PTHR10332:SF17	PTHR10332:SF17
# PIRSF	PIRSF016379	ENT
# PRINTS	PR01130	DERENTRNSPRT
# Pfam	PF01733	Nucleoside_tran
# Proteomes	UP000005640	Chromosome 10
# Reactome	R-HSA-83936	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
# RecName	S29A3_HUMAN	Equilibrative nucleoside transporter 3
# RefSeq	NP_001167569	NM_001174098.1
# RefSeq	NP_060814	NM_018344.5. [Q9BZD2-1]
# RefSeq	XP_016871866	XM_017016377.1. [Q9BZD2-2]
# SEQUENCE CAUTION	Sequence=BAA92041.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the SLC29A/ENT transporter (TC 2.A.57) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S29A3_HUMAN	Membrane; Multi-pass membrane protein. Late endosome membrane. Lysosome membrane. Note=Observed in a punctate intracellular pattern showing partial colocalization with late endosomes/lysosomes. Not detected at the cell surface. 
# TCDB	2.A.57.1	the equilibrative nucleoside transporter (ent) family
# TISSUE SPECIFICITY	Widely expressed in both adult and fetal tissues. Highest levels in placenta, uterus, ovary, spleen, lymph node and bone marrow. Lowest levels in brain and heart. {ECO:0000269|PubMed	15701636}. 
# UCSC	uc001jrr	human. [Q9BZD2-1]
# eggNOG	ENOG410Y3MT	LUCA
# eggNOG	KOG1479	Eukaryota
BLAST	swissprot:S29A3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S29A3_HUMAN
BioCyc	ZFISH:G66-33817-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33817-MONOMER
COXPRESdb	55315	http://coxpresdb.jp/data/gene/55315.shtml
CleanEx	HS_SLC29A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC29A3
DOI	10.1016/j.ajhg.2008.09.013	http://dx.doi.org/10.1016/j.ajhg.2008.09.013
DOI	10.1016/j.ejmg.2010.06.012	http://dx.doi.org/10.1016/j.ejmg.2010.06.012
DOI	10.1016/j.ejmg.2011.06.009	http://dx.doi.org/10.1016/j.ejmg.2011.06.009
DOI	10.1016/j.ijporl.2010.03.053	http://dx.doi.org/10.1016/j.ijporl.2010.03.053
DOI	10.1016/j.jdermsci.2009.09.011	http://dx.doi.org/10.1016/j.jdermsci.2009.09.011
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature02462	http://dx.doi.org/10.1038/nature02462
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M110.109199	http://dx.doi.org/10.1074/jbc.M110.109199
DOI	10.1074/jbc.M414337200	http://dx.doi.org/10.1074/jbc.M414337200
DOI	10.1080/09687680110033765	http://dx.doi.org/10.1080/09687680110033765
DOI	10.1093/hmg/ddp161	http://dx.doi.org/10.1093/hmg/ddp161
DOI	10.1093/nar/gkf564	http://dx.doi.org/10.1093/nar/gkf564
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1365-2133.2010.09653.x	http://dx.doi.org/10.1111/j.1365-2133.2010.09653.x
DOI	10.1111/j.1600-0854.2007.00643.x	http://dx.doi.org/10.1111/j.1600-0854.2007.00643.x
DOI	10.1371/journal.pgen.1000833	http://dx.doi.org/10.1371/journal.pgen.1000833
EMBL	AF326987	http://www.ebi.ac.uk/ena/data/view/AF326987
EMBL	AK002022	http://www.ebi.ac.uk/ena/data/view/AK002022
EMBL	AK304503	http://www.ebi.ac.uk/ena/data/view/AK304503
EMBL	AK314497	http://www.ebi.ac.uk/ena/data/view/AK314497
EMBL	AK316152	http://www.ebi.ac.uk/ena/data/view/AK316152
EMBL	AL359183	http://www.ebi.ac.uk/ena/data/view/AL359183
EMBL	AL359183	http://www.ebi.ac.uk/ena/data/view/AL359183
EMBL	AL359384	http://www.ebi.ac.uk/ena/data/view/AL359384
EMBL	AL359384	http://www.ebi.ac.uk/ena/data/view/AL359384
EMBL	AY288928	http://www.ebi.ac.uk/ena/data/view/AY288928
EMBL	AY358686	http://www.ebi.ac.uk/ena/data/view/AY358686
EMBL	BC000223	http://www.ebi.ac.uk/ena/data/view/BC000223
EMBL	BC041575	http://www.ebi.ac.uk/ena/data/view/BC041575
EMBL	BC120996	http://www.ebi.ac.uk/ena/data/view/BC120996
EMBL	BC120997	http://www.ebi.ac.uk/ena/data/view/BC120997
EMBL	BK000392	http://www.ebi.ac.uk/ena/data/view/BK000392
Ensembl	ENST00000373189	http://www.ensembl.org/id/ENST00000373189
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0031902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031902
GO_function	GO:0005337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005337
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GeneCards	SLC29A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC29A3
GeneID	55315	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55315
GeneTree	ENSGT00390000002232	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002232
H-InvDB	HIX0008903	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0008903
HGNC	HGNC:23096	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:23096
HOVERGEN	HBG108444	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108444&db=HOVERGEN
HPA	HPA054976	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA054976
InParanoid	Q9BZD2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9BZD2
InterPro	IPR002259	http://www.ebi.ac.uk/interpro/entry/IPR002259
InterPro	IPR030193	http://www.ebi.ac.uk/interpro/entry/IPR030193
Jabion	55315	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55315
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00815	http://www.genome.jp/dbget-bin/www_bget?H00815
KEGG_Gene	hsa:55315	http://www.genome.jp/dbget-bin/www_bget?hsa:55315
KEGG_Orthology	KO:K15014	http://www.genome.jp/dbget-bin/www_bget?KO:K15014
MIM	602782	http://www.ncbi.nlm.nih.gov/omim/602782
MIM	612373	http://www.ncbi.nlm.nih.gov/omim/612373
OMA	YYMRPVL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YYMRPVL
Orphanet	168569	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=168569
Orphanet	1782	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1782
OrthoDB	EOG091G09WB	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G09WB
PANTHER	PTHR10332	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10332
PANTHER	PTHR10332:SF17	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10332:SF17
PRINTS	PR01130	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01130
PSORT	swissprot:S29A3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S29A3_HUMAN
PSORT-B	swissprot:S29A3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S29A3_HUMAN
PSORT2	swissprot:S29A3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S29A3_HUMAN
Pfam	PF01733	http://pfam.xfam.org/family/PF01733
PharmGKB	PA134950750	http://www.pharmgkb.org/do/serve?objId=PA134950750&objCls=Gene
Phobius	swissprot:S29A3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S29A3_HUMAN
PhylomeDB	Q9BZD2	http://phylomedb.org/?seqid=Q9BZD2
ProteinModelPortal	Q9BZD2	http://www.proteinmodelportal.org/query/uniprot/Q9BZD2
PubMed	11396612	http://www.ncbi.nlm.nih.gov/pubmed/11396612
PubMed	12384580	http://www.ncbi.nlm.nih.gov/pubmed/12384580
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15164054	http://www.ncbi.nlm.nih.gov/pubmed/15164054
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15701636	http://www.ncbi.nlm.nih.gov/pubmed/15701636
PubMed	17897319	http://www.ncbi.nlm.nih.gov/pubmed/17897319
PubMed	18940313	http://www.ncbi.nlm.nih.gov/pubmed/18940313
PubMed	19336477	http://www.ncbi.nlm.nih.gov/pubmed/19336477
PubMed	19889517	http://www.ncbi.nlm.nih.gov/pubmed/19889517
PubMed	20140240	http://www.ncbi.nlm.nih.gov/pubmed/20140240
PubMed	20199539	http://www.ncbi.nlm.nih.gov/pubmed/20199539
PubMed	20399510	http://www.ncbi.nlm.nih.gov/pubmed/20399510
PubMed	20595384	http://www.ncbi.nlm.nih.gov/pubmed/20595384
PubMed	20619369	http://www.ncbi.nlm.nih.gov/pubmed/20619369
PubMed	21888995	http://www.ncbi.nlm.nih.gov/pubmed/21888995
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
Reactome	R-HSA-83936	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-83936
RefSeq	NP_001167569	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001167569
RefSeq	NP_060814	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060814
RefSeq	XP_016871866	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016871866
STRING	9606.ENSP00000362285	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000362285&targetmode=cogs
TCDB	2.A.57.1	http://www.tcdb.org/search/result.php?tc=2.A.57.1
UCSC	uc001jrr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001jrr&org=rat
UniGene	Hs.438419	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.438419
UniProtKB	S29A3_HUMAN	http://www.uniprot.org/uniprot/S29A3_HUMAN
UniProtKB-AC	Q9BZD2	http://www.uniprot.org/uniprot/Q9BZD2
charge	swissprot:S29A3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S29A3_HUMAN
eggNOG	ENOG410Y3MT	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y3MT
eggNOG	KOG1479	http://eggnogapi.embl.de/nog_data/html/tree/KOG1479
epestfind	swissprot:S29A3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S29A3_HUMAN
garnier	swissprot:S29A3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S29A3_HUMAN
helixturnhelix	swissprot:S29A3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S29A3_HUMAN
hmoment	swissprot:S29A3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S29A3_HUMAN
iep	swissprot:S29A3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S29A3_HUMAN
inforesidue	swissprot:S29A3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S29A3_HUMAN
neXtProt	NX_Q9BZD2	http://www.nextprot.org/db/entry/NX_Q9BZD2
octanol	swissprot:S29A3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S29A3_HUMAN
pepcoil	swissprot:S29A3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S29A3_HUMAN
pepdigest	swissprot:S29A3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S29A3_HUMAN
pepinfo	swissprot:S29A3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S29A3_HUMAN
pepnet	swissprot:S29A3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S29A3_HUMAN
pepstats	swissprot:S29A3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S29A3_HUMAN
pepwheel	swissprot:S29A3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S29A3_HUMAN
pepwindow	swissprot:S29A3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S29A3_HUMAN
sigcleave	swissprot:S29A3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S29A3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AT1A4_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13733-1; Sequence=Displayed; Name=2; IsoId=Q13733-2; Sequence=VSP_007364; Note=No experimental confirmation available.; 
# AltName	AT1A4_HUMAN	Sodium pump subunit alpha-4
# BioGrid	106970	9
# CATALYTIC ACTIVITY	AT1A4_HUMAN	ATP + H(2)O + Na(+)(In) + K(+)(Out) = ADP + phosphate + Na(+)(Out) + K(+)(In). 
# CCDS	CCDS1197	-. [Q13733-1]
# CCDS	CCDS44255	-. [Q13733-2]
# ChiTaRS	ATP1A4	human
# ENZYME REGULATION	Specifically inhibited by an endogenous cardiac glycoside, ouabain. {ECO:0000269|PubMed	16175638}. 
# Ensembl	ENST00000368081	ENSP00000357060; ENSG00000132681. [Q13733-1]
# Ensembl	ENST00000470705	ENSP00000433094; ENSG00000132681. [Q13733-2]
# ExpressionAtlas	Q13733	baseline and differential
# FUNCTION	AT1A4_HUMAN	This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility. 
# GO_component	AT1A4_HUMAN	GO 0005890 sodium potassium-exchanging ATPase complex; TAS UniProtKB.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; NAS:UniProtKB.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IBA:GO_Central.
# GO_function	AT1A4_HUMAN	GO 0005391 sodium potassium-exchanging ATPase activity; TAS UniProtKB.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0006813	potassium ion transport; TAS:UniProtKB.
# GO_process	GO:0006814	sodium ion transport; TAS:UniProtKB.
# GO_process	GO:0006883	cellular sodium ion homeostasis; IBA:GO_Central.
# GO_process	GO:0007283	spermatogenesis; IEA:Ensembl.
# GO_process	GO:0009566	fertilization; IEA:Ensembl.
# GO_process	GO:0010107	potassium ion import; IBA:GO_Central.
# GO_process	GO:0015991	ATP hydrolysis coupled proton transport; TAS:UniProtKB.
# GO_process	GO:0030007	cellular potassium ion homeostasis; IBA:GO_Central.
# GO_process	GO:0030317	flagellated sperm motility; IDA:UniProtKB.
# GO_process	GO:0030641	regulation of cellular pH; IDA:UniProtKB.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0036376	sodium ion export from cell; IBA:GO_Central.
# GO_process	GO:0042391	regulation of membrane potential; IEA:Ensembl.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048870	cell motility
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.1110.10	-; 2.
# Gene3D	2.70.150.10	-; 2.
# Gene3D	3.40.1110.10	-; 1.
# Genevisible	Q13733	HS
# HGNC	HGNC:14073	ATP1A4
# InterPro	IPR001757	P_typ_ATPase
# InterPro	IPR004014	ATPase_P-typ_cation-transptr_N
# InterPro	IPR005775	P-type_ATPase_IIC
# InterPro	IPR006068	ATPase_P-typ_cation-transptr_C
# InterPro	IPR008250	ATPase_P-typ_transduc_dom_A
# InterPro	IPR018303	ATPase_P-typ_P_site
# InterPro	IPR023214	HAD-like_dom
# InterPro	IPR023298	ATPase_P-typ_TM_dom
# InterPro	IPR023299	ATPase_P-typ_cyto_domN
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko04960	Aldosterone-regulated sodium reabsorption
# KEGG_Pathway	ko04961	Endocrine and other factor-regulated calcium reabsorption
# KEGG_Pathway	ko04964	Proximal tubule bicarbonate reclamation
# KEGG_Pathway	ko04970	Salivary secretion
# KEGG_Pathway	ko04971	Gastric acid secretion
# KEGG_Pathway	ko04972	Pancreatic secretion
# KEGG_Pathway	ko04973	Carbohydrate digestion and absorption
# KEGG_Pathway	ko04974	Protein digestion and absorption
# KEGG_Pathway	ko04976	Bile secretion
# KEGG_Pathway	ko04978	Mineral absorption
# MIM	607321	gene
# Organism	AT1A4_HUMAN	Homo sapiens (Human)
# PROSITE	PS00154	ATPASE_E1_E2
# Pfam	PF00122	E1-E2_ATPase
# Pfam	PF00689	Cation_ATPase_C
# Pfam	PF00690	Cation_ATPase_N
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-5578775	Ion homeostasis
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	AT1A4_HUMAN	Sodium/potassium-transporting ATPase subunit alpha-4
# RefSeq	NP_001001734	NM_001001734.1. [Q13733-2]
# RefSeq	NP_653300	NM_144699.3. [Q13733-1]
# SEQUENCE CAUTION	Sequence=AAQ07964.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC05228.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. {ECO	0000305}. 
# SMART	SM00831	Cation_ATPase_N
# SUBCELLULAR LOCATION	AT1A4_HUMAN	Cell membrane {ECO 0000269|PubMed 16175638}; Multi-pass membrane protein {ECO 0000269|PubMed 16175638}. Note=In mature sperm, located in the principle piece of the sperm flagellum. 
# SUBUNIT	Composed of three subunits	 alpha (catalytic), beta and gamma. 
# SUPFAM	SSF56784	SSF56784; 2
# SUPFAM	SSF81660	SSF81660
# TIGRFAMs	TIGR01106	ATPase-IIC_X-K
# TIGRFAMs	TIGR01494	ATPase_P-type; 2
# TISSUE SPECIFICITY	AT1A4_HUMAN	Specifically expressed in testis. Found in very low levels in skeletal muscle. Expressed in mature sperm (at protein level). 
# UCSC	uc001fve	human. [Q13733-1]
# eggNOG	COG0474	LUCA
# eggNOG	KOG0203	Eukaryota
BLAST	swissprot:AT1A4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AT1A4_HUMAN
BioCyc	ZFISH:HS05675-MONOMER	http://biocyc.org/getid?id=ZFISH:HS05675-MONOMER
COXPRESdb	480	http://coxpresdb.jp/data/gene/480.shtml
CleanEx	HS_ATP1A4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP1A4
DOI	10.1002/mrd.20383	http://dx.doi.org/10.1002/mrd.20383
DOI	10.1016/S0378-1119(02)00647-9	http://dx.doi.org/10.1016/S0378-1119(02)00647-9
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.91.26.12952	http://dx.doi.org/10.1073/pnas.91.26.12952
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EC_number	EC:3.6.3.9	http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.9
EMBL	AF310646	http://www.ebi.ac.uk/ena/data/view/AF310646
EMBL	AF352828	http://www.ebi.ac.uk/ena/data/view/AF352828
EMBL	AF390027	http://www.ebi.ac.uk/ena/data/view/AF390027
EMBL	AF421887	http://www.ebi.ac.uk/ena/data/view/AF421887
EMBL	AF430843	http://www.ebi.ac.uk/ena/data/view/AF430843
EMBL	AF459737	http://www.ebi.ac.uk/ena/data/view/AF459737
EMBL	AF506797	http://www.ebi.ac.uk/ena/data/view/AF506797
EMBL	AH002997	http://www.ebi.ac.uk/ena/data/view/AH002997
EMBL	AK098076	http://www.ebi.ac.uk/ena/data/view/AK098076
EMBL	AL121987	http://www.ebi.ac.uk/ena/data/view/AL121987
EMBL	AY039031	http://www.ebi.ac.uk/ena/data/view/AY039031
EMBL	BC028297	http://www.ebi.ac.uk/ena/data/view/BC028297
EMBL	BC094801	http://www.ebi.ac.uk/ena/data/view/BC094801
ENZYME	3.6.3.9	http://enzyme.expasy.org/EC/3.6.3.9
Ensembl	ENST00000368081	http://www.ensembl.org/id/ENST00000368081
Ensembl	ENST00000470705	http://www.ensembl.org/id/ENST00000470705
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005890
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0005391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005391
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0006883	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006883
GO_process	GO:0007283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007283
GO_process	GO:0009566	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009566
GO_process	GO:0010107	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010107
GO_process	GO:0015991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015991
GO_process	GO:0030007	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030007
GO_process	GO:0030317	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030317
GO_process	GO:0030641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030641
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0036376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036376
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.1110.10	http://www.cathdb.info/version/latest/superfamily/1.20.1110.10
Gene3D	2.70.150.10	http://www.cathdb.info/version/latest/superfamily/2.70.150.10
Gene3D	3.40.1110.10	http://www.cathdb.info/version/latest/superfamily/3.40.1110.10
GeneCards	ATP1A4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP1A4
GeneID	480	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=480
GeneTree	ENSGT00850000132256	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00850000132256
HGNC	HGNC:14073	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14073
HOVERGEN	HBG004298	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004298&db=HOVERGEN
InParanoid	Q13733	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q13733
IntAct	Q13733	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q13733*
IntEnz	3.6.3.9	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.9
InterPro	IPR001757	http://www.ebi.ac.uk/interpro/entry/IPR001757
InterPro	IPR004014	http://www.ebi.ac.uk/interpro/entry/IPR004014
InterPro	IPR005775	http://www.ebi.ac.uk/interpro/entry/IPR005775
InterPro	IPR006068	http://www.ebi.ac.uk/interpro/entry/IPR006068
InterPro	IPR008250	http://www.ebi.ac.uk/interpro/entry/IPR008250
InterPro	IPR018303	http://www.ebi.ac.uk/interpro/entry/IPR018303
InterPro	IPR023214	http://www.ebi.ac.uk/interpro/entry/IPR023214
InterPro	IPR023298	http://www.ebi.ac.uk/interpro/entry/IPR023298
InterPro	IPR023299	http://www.ebi.ac.uk/interpro/entry/IPR023299
Jabion	480	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=480
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:480	http://www.genome.jp/dbget-bin/www_bget?hsa:480
KEGG_Orthology	KO:K01539	http://www.genome.jp/dbget-bin/www_bget?KO:K01539
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko04960	http://www.genome.jp/kegg-bin/show_pathway?ko04960
KEGG_Pathway	ko04961	http://www.genome.jp/kegg-bin/show_pathway?ko04961
KEGG_Pathway	ko04964	http://www.genome.jp/kegg-bin/show_pathway?ko04964
KEGG_Pathway	ko04970	http://www.genome.jp/kegg-bin/show_pathway?ko04970
KEGG_Pathway	ko04971	http://www.genome.jp/kegg-bin/show_pathway?ko04971
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
KEGG_Pathway	ko04973	http://www.genome.jp/kegg-bin/show_pathway?ko04973
KEGG_Pathway	ko04974	http://www.genome.jp/kegg-bin/show_pathway?ko04974
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
KEGG_Pathway	ko04978	http://www.genome.jp/kegg-bin/show_pathway?ko04978
MIM	607321	http://www.ncbi.nlm.nih.gov/omim/607321
OMA	KSSDTWF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KSSDTWF
OrthoDB	EOG091G01BB	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01BB
PROSITE	PS00154	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00154
PSORT	swissprot:AT1A4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AT1A4_HUMAN
PSORT-B	swissprot:AT1A4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AT1A4_HUMAN
PSORT2	swissprot:AT1A4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AT1A4_HUMAN
Pfam	PF00122	http://pfam.xfam.org/family/PF00122
Pfam	PF00689	http://pfam.xfam.org/family/PF00689
Pfam	PF00690	http://pfam.xfam.org/family/PF00690
PharmGKB	PA65	http://www.pharmgkb.org/do/serve?objId=PA65&objCls=Gene
Phobius	swissprot:AT1A4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AT1A4_HUMAN
PhylomeDB	Q13733	http://phylomedb.org/?seqid=Q13733
ProteinModelPortal	Q13733	http://www.proteinmodelportal.org/query/uniprot/Q13733
PubMed	12119109	http://www.ncbi.nlm.nih.gov/pubmed/12119109
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16175638	http://www.ncbi.nlm.nih.gov/pubmed/16175638
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	7809153	http://www.ncbi.nlm.nih.gov/pubmed/7809153
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_001001734	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001001734
RefSeq	NP_653300	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_653300
SMART	SM00831	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00831
SMR	Q13733	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q13733
STRING	9606.ENSP00000357060	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000357060&targetmode=cogs
SUPFAM	SSF56784	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784
SUPFAM	SSF81660	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81660
TIGRFAMs	TIGR01106	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01106
TIGRFAMs	TIGR01494	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01494
UCSC	uc001fve	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001fve&org=rat
UniGene	Hs.662219	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.662219
UniProtKB	AT1A4_HUMAN	http://www.uniprot.org/uniprot/AT1A4_HUMAN
UniProtKB-AC	Q13733	http://www.uniprot.org/uniprot/Q13733
charge	swissprot:AT1A4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AT1A4_HUMAN
eggNOG	COG0474	http://eggnogapi.embl.de/nog_data/html/tree/COG0474
eggNOG	KOG0203	http://eggnogapi.embl.de/nog_data/html/tree/KOG0203
epestfind	swissprot:AT1A4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AT1A4_HUMAN
garnier	swissprot:AT1A4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AT1A4_HUMAN
helixturnhelix	swissprot:AT1A4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AT1A4_HUMAN
hmoment	swissprot:AT1A4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AT1A4_HUMAN
iep	swissprot:AT1A4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AT1A4_HUMAN
inforesidue	swissprot:AT1A4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AT1A4_HUMAN
neXtProt	NX_Q13733	http://www.nextprot.org/db/entry/NX_Q13733
octanol	swissprot:AT1A4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AT1A4_HUMAN
pepcoil	swissprot:AT1A4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AT1A4_HUMAN
pepdigest	swissprot:AT1A4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AT1A4_HUMAN
pepinfo	swissprot:AT1A4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AT1A4_HUMAN
pepnet	swissprot:AT1A4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AT1A4_HUMAN
pepstats	swissprot:AT1A4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AT1A4_HUMAN
pepwheel	swissprot:AT1A4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AT1A4_HUMAN
pepwindow	swissprot:AT1A4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AT1A4_HUMAN
sigcleave	swissprot:AT1A4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AT1A4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ABCAD_HUMAN	Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=Q86UQ4-1; Sequence=Displayed; Name=2; IsoId=Q86UQ4-2; Sequence=VSP_021069, VSP_021070; Note=No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; IsoId=Q86UQ4-3; Sequence=VSP_021068; Name=4; IsoId=Q86UQ4-4; Sequence=VSP_054634; Name=5; IsoId=Q86UQ4-5; Sequence=VSP_054633, VSP_054634; Name=6; IsoId=Q86UQ4-6; Sequence=VSP_054633, VSP_054634, VSP_054636; Name=7; IsoId=Q86UQ4-7; Sequence=VSP_054633, VSP_054634, VSP_054635; 
# BioGrid	127551	5
# CCDS	CCDS47584	-. [Q86UQ4-1]
# ChiTaRS	ABCA13	human
# Ensembl	ENST00000417403	ENSP00000409268; ENSG00000179869. [Q86UQ4-2]
# ExpressionAtlas	Q86UQ4	baseline and differential
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IBA:GO_Central.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; IBA:GO_Central.
# GO_process	GO:0033344	cholesterol efflux; IBA:GO_Central.
# GO_process	GO:0033700	phospholipid efflux; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# Gene3D	3.40.50.300	-; 2.
# HGNC	HGNC:14638	ABCA13
# IntAct	Q86UQ4	2
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR026082	ABC_A
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko02010	ABC transporters
# MIM	607807	gene
# Organism	ABCAD_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR19229	PTHR19229; 3
# PROSITE	PS50893	ABC_TRANSPORTER_2; 2
# Pfam	PF00005	ABC_tran; 2
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-6798695	Neutrophil degranulation
# RecName	ABCAD_HUMAN	ATP-binding cassette sub-family A member 13
# RefSeq	NP_689914	NM_152701.4
# SEQUENCE CAUTION	Sequence=BAC03623.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC86492.1; Type=Erroneous termination; Positions=123; Note=Translated as Glu.; Evidence={ECO	0000305}; Sequence=BAC86492.1; Type=Frameshift; Positions=156; Evidence={ECO:0000305}; 
# SIMILARITY	Belongs to the ABC transporter superfamily. {ECO	0000305}. 
# SIMILARITY	Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA; 2
# SUBCELLULAR LOCATION	ABCAD_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF52540	SSF52540; 2
# TCDB	3.A.1.211.18	the atp-binding cassette (abc) superfamily
# TISSUE SPECIFICITY	ABCAD_HUMAN	Significantly expressed in the bone marrow, trachea, testis, thyroid and lung as well as in skin fibroblasts. {ECO 0000269|PubMed 12697998, ECO 0000269|PubMed 23266639}. 
# UCSC	uc064dot	human. [Q86UQ4-1]
# WEB RESOURCE	ABCAD_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=Q86UQ4";
# eggNOG	COG1131	LUCA
# eggNOG	KOG0059	Eukaryota
BLAST	swissprot:ABCAD_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCAD_HUMAN
COXPRESdb	154664	http://coxpresdb.jp/data/gene/154664.shtml
CleanEx	HS_ABCA13	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCA13
DOI	10.1016/j.gene.2012.11.072	http://dx.doi.org/10.1016/j.gene.2012.11.072
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1159/000069852	http://dx.doi.org/10.1159/000069852
EMBL	AC073424	http://www.ebi.ac.uk/ena/data/view/AC073424
EMBL	AC073927	http://www.ebi.ac.uk/ena/data/view/AC073927
EMBL	AC091770	http://www.ebi.ac.uk/ena/data/view/AC091770
EMBL	AC095039	http://www.ebi.ac.uk/ena/data/view/AC095039
EMBL	AC232300	http://www.ebi.ac.uk/ena/data/view/AC232300
EMBL	AC232312	http://www.ebi.ac.uk/ena/data/view/AC232312
EMBL	AF501281	http://www.ebi.ac.uk/ena/data/view/AF501281
EMBL	AK091270	http://www.ebi.ac.uk/ena/data/view/AK091270
EMBL	AK126220	http://www.ebi.ac.uk/ena/data/view/AK126220
EMBL	AY204751	http://www.ebi.ac.uk/ena/data/view/AY204751
EMBL	JF913488	http://www.ebi.ac.uk/ena/data/view/JF913488
EMBL	JF913489	http://www.ebi.ac.uk/ena/data/view/JF913489
EMBL	JF913490	http://www.ebi.ac.uk/ena/data/view/JF913490
EMBL	JF913491	http://www.ebi.ac.uk/ena/data/view/JF913491
EMBL	JF913492	http://www.ebi.ac.uk/ena/data/view/JF913492
Ensembl	ENST00000417403	http://www.ensembl.org/id/ENST00000417403
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GO_process	GO:0033344	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033344
GO_process	GO:0033700	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033700
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCA13	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCA13
GeneID	154664	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=154664
GeneTree	ENSGT00760000118965	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118965
H-InvDB	HIX0006678	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0006678
H-InvDB	HIX0033928	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0033928
HGNC	HGNC:14638	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14638
HOGENOM	HOG000033760	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000033760&db=HOGENOM6
HOVERGEN	HBG080808	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG080808&db=HOVERGEN
InParanoid	Q86UQ4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q86UQ4
IntAct	Q86UQ4	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q86UQ4*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR026082	http://www.ebi.ac.uk/interpro/entry/IPR026082
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	154664	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=154664
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:154664	http://www.genome.jp/dbget-bin/www_bget?hsa:154664
KEGG_Orthology	KO:K05647	http://www.genome.jp/dbget-bin/www_bget?KO:K05647
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
MIM	607807	http://www.ncbi.nlm.nih.gov/omim/607807
PANTHER	PTHR19229	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19229
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PSORT	swissprot:ABCAD_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCAD_HUMAN
PSORT-B	swissprot:ABCAD_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCAD_HUMAN
PSORT2	swissprot:ABCAD_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCAD_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
PharmGKB	PA134925234	http://www.pharmgkb.org/do/serve?objId=PA134925234&objCls=Gene
Phobius	swissprot:ABCAD_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCAD_HUMAN
PhylomeDB	Q86UQ4	http://phylomedb.org/?seqid=Q86UQ4
ProteinModelPortal	Q86UQ4	http://www.proteinmodelportal.org/query/uniprot/Q86UQ4
PubMed	12697998	http://www.ncbi.nlm.nih.gov/pubmed/12697998
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	23266639	http://www.ncbi.nlm.nih.gov/pubmed/23266639
Reactome	R-HSA-6798695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6798695
RefSeq	NP_689914	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_689914
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	Q86UQ4	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q86UQ4
STRING	9606.ENSP00000411096	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000411096&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TCDB	3.A.1.211.18	http://www.tcdb.org/search/result.php?tc=3.A.1.211.18
UCSC	uc064dot	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc064dot&org=rat
UniGene	Hs.226568	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.226568
UniGene	Hs.745575	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.745575
UniProtKB	ABCAD_HUMAN	http://www.uniprot.org/uniprot/ABCAD_HUMAN
UniProtKB-AC	Q86UQ4	http://www.uniprot.org/uniprot/Q86UQ4
charge	swissprot:ABCAD_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCAD_HUMAN
eggNOG	COG1131	http://eggnogapi.embl.de/nog_data/html/tree/COG1131
eggNOG	KOG0059	http://eggnogapi.embl.de/nog_data/html/tree/KOG0059
epestfind	swissprot:ABCAD_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCAD_HUMAN
garnier	swissprot:ABCAD_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCAD_HUMAN
helixturnhelix	swissprot:ABCAD_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCAD_HUMAN
hmoment	swissprot:ABCAD_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCAD_HUMAN
iep	swissprot:ABCAD_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCAD_HUMAN
inforesidue	swissprot:ABCAD_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCAD_HUMAN
neXtProt	NX_Q86UQ4	http://www.nextprot.org/db/entry/NX_Q86UQ4
octanol	swissprot:ABCAD_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCAD_HUMAN
pepcoil	swissprot:ABCAD_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCAD_HUMAN
pepdigest	swissprot:ABCAD_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCAD_HUMAN
pepinfo	swissprot:ABCAD_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCAD_HUMAN
pepnet	swissprot:ABCAD_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCAD_HUMAN
pepstats	swissprot:ABCAD_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCAD_HUMAN
pepwheel	swissprot:ABCAD_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCAD_HUMAN
pepwindow	swissprot:ABCAD_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCAD_HUMAN
sigcleave	swissprot:ABCAD_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCAD_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=5; Name=2; Synonyms=Non-IRE, DMT1B; IsoId=P49281-1; Sequence=Displayed; Name=1; Synonyms=IRE; IsoId=P49281-2; Sequence=VSP_003595; Name=3; Synonyms=1A-IRE; IsoId=P49281-3; Sequence=VSP_038144, VSP_003595; Name=4; Synonyms=1A-Non-IRE; IsoId=P49281-4; Sequence=VSP_038144; Note=No experimental confirmation available.; Name=5; IsoId=P49281-5; Sequence=VSP_046058, VSP_003595; Note=No experimental confirmation available. Ref.6 (BAG59096/BAH14878) sequences are in conflict in position: 6	Y->S. {ECO:0000305}; 
# AltName	NRAM2_HUMAN	Divalent cation transporter 1
# AltName	NRAM2_HUMAN	Divalent metal transporter 1
# AltName	NRAM2_HUMAN	Solute carrier family 11 member 2
# BIOPHYSICOCHEMICAL PROPERTIES	pH dependence: Optimum pH is 5.5-6.5 for Fe(2+) uptake. {ECO	0000269|PubMed:17293870}; 
# BioGrid	110950	7
# CCDS	CCDS53791	-. [P49281-5]
# CCDS	CCDS53792	-. [P49281-1]
# CCDS	CCDS53793	-. [P49281-3]
# CCDS	CCDS8805	-. [P49281-2]
# ChiTaRS	SLC11A2	human
# DISEASE	NRAM2_HUMAN	Anemia, hypochromic microcytic, with iron overload 1 (AHMIO1) [MIM 206100]  A hematologic disease characterized by abnormal hemoglobin content in the erythrocytes which are reduced in size. The disorder is due to an error of iron metabolism that results in high serum iron, massive hepatic iron deposition, and absence of sideroblasts and stainable bone marrow iron store. Despite adequate transferrin-iron complex, delivery of iron to the erythroid bone marrow is apparently insufficient for the demands of hemoglobin synthesis. {ECO 0000269|PubMed 15459009, ECO 0000269|PubMed 16160008, ECO 0000269|PubMed 16439678}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000262051	ENSP00000262051; ENSG00000110911. [P49281-1]
# Ensembl	ENST00000262052	ENSP00000262052; ENSG00000110911. [P49281-2]
# Ensembl	ENST00000394904	ENSP00000378364; ENSG00000110911. [P49281-3]
# Ensembl	ENST00000541174	ENSP00000444542; ENSG00000110911. [P49281-2]
# Ensembl	ENST00000545993	ENSP00000442810; ENSG00000110911. [P49281-5]
# Ensembl	ENST00000546636	ENSP00000449008; ENSG00000110911. [P49281-1]
# Ensembl	ENST00000547198	ENSP00000446769; ENSG00000110911. [P49281-1]
# Ensembl	ENST00000547688	ENSP00000449200; ENSG00000110911. [P49281-3]
# ExpressionAtlas	P49281	baseline and differential
# FUNCTION	NRAM2_HUMAN	Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria. {ECO 0000269|PubMed 17109629, ECO 0000269|PubMed 24448823, ECO 0000269|PubMed 25326704, ECO 0000269|PubMed 25491917}. 
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005737	cytoplasm; IDA:BHF-UCL.
# GO_component	GO:0005741	mitochondrial outer membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005764	lysosome; IDA:UniProtKB.
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005769	early endosome; IDA:UniProtKB.
# GO_component	GO:0005770	late endosome; IDA:UniProtKB.
# GO_component	GO:0005773	vacuole; IMP:BHF-UCL.
# GO_component	GO:0005802	trans-Golgi network; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0009986	cell surface; IDA:UniProtKB.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_component	GO:0031410	cytoplasmic vesicle; IDA:UniProtKB.
# GO_component	GO:0031526	brush border membrane; ISS:BHF-UCL.
# GO_component	GO:0031902	late endosome membrane; IDA:BHF-UCL.
# GO_component	GO:0045177	apical part of cell; IDA:UniProtKB.
# GO_component	GO:0045178	basal part of cell; IDA:UniProtKB.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IDA:BHF-UCL.
# GO_component	GO:0055037	recycling endosome; IDA:UniProtKB.
# GO_component	GO:0070826	paraferritin complex; IDA:UniProtKB.
# GO_function	GO:0005375	copper ion transmembrane transporter activity; IDA:BHF-UCL.
# GO_function	GO:0005381	iron ion transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0005384	manganese ion transmembrane transporter activity; IDA:BHF-UCL.
# GO_function	GO:0005385	zinc ion transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015078	hydrogen ion transmembrane transporter activity; IEA:Ensembl.
# GO_function	GO:0015086	cadmium ion transmembrane transporter activity; IDA:BHF-UCL.
# GO_function	GO:0015087	cobalt ion transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015093	ferrous iron transmembrane transporter activity; IDA:BHF-UCL.
# GO_function	GO:0015094	lead ion transmembrane transporter activity; IDA:BHF-UCL.
# GO_function	GO:0015099	nickel cation transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015100	vanadium ion transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015639	ferrous iron uptake transmembrane transporter activity; IMP:UniProtKB.
# GO_function	GO:0022890	inorganic cation transmembrane transporter activity; IGI:UniProtKB.
# GO_function	GO:0046870	cadmium ion binding; IDA:UniProtKB.
# GO_function	GO:0046915	transition metal ion transmembrane transporter activity; IDA:UniProtKB.
# GO_function	NRAM2_HUMAN	GO 0015295 solute proton symporter activity; IDA UniProtKB.
# GO_process	GO:0001666	response to hypoxia; IEP:UniProtKB.
# GO_process	GO:0003032	detection of oxygen; IEP:UniProtKB.
# GO_process	GO:0006783	heme biosynthetic process; IEA:Ensembl.
# GO_process	GO:0006824	cobalt ion transport; IDA:UniProtKB.
# GO_process	GO:0006825	copper ion transport; IDA:BHF-UCL.
# GO_process	GO:0006828	manganese ion transport; IDA:BHF-UCL.
# GO_process	GO:0006879	cellular iron ion homeostasis; TAS:Reactome.
# GO_process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.
# GO_process	GO:0007611	learning or memory; IEA:Ensembl.
# GO_process	GO:0010039	response to iron ion; IEP:UniProtKB.
# GO_process	GO:0015675	nickel cation transport; IDA:UniProtKB.
# GO_process	GO:0015676	vanadium ion transport; IDA:UniProtKB.
# GO_process	GO:0015684	ferrous iron transport; IDA:BHF-UCL.
# GO_process	GO:0015692	lead ion transport; IDA:BHF-UCL.
# GO_process	GO:0034599	cellular response to oxidative stress; IDA:UniProtKB.
# GO_process	GO:0048813	dendrite morphogenesis; IEA:Ensembl.
# GO_process	GO:0048821	erythrocyte development; IEA:Ensembl.
# GO_process	GO:0060586	multicellular organismal iron ion homeostasis; IMP:BHF-UCL.
# GO_process	GO:0070574	cadmium ion transmembrane transport; IDA:UniProtKB.
# GO_process	GO:0070627	ferrous iron import; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005764	lysosome
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005773	vacuole
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0051186	cofactor metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P49281	HS
# HAMAP	MF_00221	NRAMP
# HGNC	HGNC:10908	SLC11A2
# INTERACTION	NRAM2_HUMAN	P00403 MT-CO2; NbExp=2; IntAct=EBI-10828817, EBI-2105756; 
# IntAct	P49281	4
# InterPro	IPR001046	NRAMP_fam
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H01196	[Hematologic disease] Hypochromic microcytic anemia
# KEGG_Pathway	ko04142	Lysosome
# KEGG_Pathway	ko04978	Mineral absorption
# MIM	206100	phenotype
# MIM	600523	gene
# MISCELLANEOUS	NRAM2_HUMAN	NRAMP2-mediated iron uptake is markedly stimulated by nifedipine in a concentration-dependent manner. 
# Organism	NRAM2_HUMAN	Homo sapiens (Human)
# Orphanet	83642	Microcytic anemia with liver iron overload
# PIR	I57022	I57022
# PRINTS	PR00447	NATRESASSCMP
# PTM	NRAM2_HUMAN	N-glycosylated. {ECO 0000269|PubMed 25491917}. 
# PTM	NRAM2_HUMAN	Ubiquitinated by WWP2. {ECO 0000250}. 
# Pfam	PF01566	Nramp
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-425410	Metal ion SLC transporters
# Reactome	R-HSA-917937	Iron uptake and transport
# RecName	NRAM2_HUMAN	Natural resistance-associated macrophage protein 2
# RefSeq	NP_000608	NM_000617.2. [P49281-2]
# RefSeq	NP_001167596	NM_001174125.1. [P49281-3]
# RefSeq	NP_001167597	NM_001174126.1. [P49281-1]
# RefSeq	NP_001167598	NM_001174127.1. [P49281-1]
# RefSeq	NP_001167599	NM_001174128.1. [P49281-2]
# RefSeq	NP_001167600	NM_001174129.1. [P49281-2]
# RefSeq	NP_001167601	NM_001174130.1. [P49281-5]
# RefSeq	XP_005268968	XM_005268911.3. [P49281-4]
# RefSeq	XP_011536706	XM_011538404.2. [P49281-1]
# RefSeq	XP_011536707	XM_011538405.2. [P49281-1]
# RefSeq	XP_016874844	XM_017019355.1. [P49281-1]
# SEQUENCE CAUTION	Sequence=AAH02592.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA34374.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the NRAMP family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	NRAM2_HUMAN	Endosome membrane {ECO 0000269|PubMed 12475959, ECO 0000269|PubMed 18776082, ECO 0000269|PubMed 25491917}; Multi-pass membrane protein {ECO 0000269|PubMed 18776082}. Mitochondrion outer membrane {ECO 0000269|PubMed 24448823}; Multi-pass membrane protein. Cell membrane {ECO 0000269|PubMed 12475959, ECO 0000269|PubMed 25326704, ECO 0000269|PubMed 25491917}; Multi- pass membrane protein {ECO 0000305}. 
# SUBCELLULAR LOCATION	NRAM2_HUMAN	Isoform 2  Cell membrane {ECO 0000269|PubMed 12475959, ECO 0000269|PubMed 25491917}; Multi- pass membrane protein {ECO 0000305}. Early endosome {ECO 0000269|PubMed 12475959}. 
# SUBUNIT	NRAM2_HUMAN	Forms a complex with NDFIP1 and NEDD4L, in cortical neurons, in response to iron and colbalt exposure; this interaction leads to ubiquitination by NEDD4L and proteasome- dependent degradation. Interacts with NDFIP2. Interacts with COX2 and TOM6 at the outer mitochondrion membrane. {ECO 0000269|PubMed 18776082, ECO 0000269|PubMed 19706893, ECO 0000269|PubMed 24448823}. 
# TCDB	2.A.55.2	the metal ion (mn(2+)-iron) transporter (nramp) family
# TIGRFAMs	TIGR01197	nramp
# TISSUE SPECIFICITY	NRAM2_HUMAN	Ubiquitously expressed. Isoform 1 is highly expressed in brain. Isoform 2 is highly expressed in spleen, thymus and pancreas. Isoform 3 and isoform 4 are abundantly expressed in duodenum and kidney. {ECO 0000269|PubMed 12209011, ECO 0000269|PubMed 9642100}. 
# UCSC	uc001rxc	human. [P49281-1]
# eggNOG	COG1914	LUCA
# eggNOG	KOG1291	Eukaryota
BLAST	swissprot:NRAM2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NRAM2_HUMAN
BioCyc	ZFISH:ENSG00000110911-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000110911-MONOMER
COXPRESdb	4891	http://coxpresdb.jp/data/gene/4891.shtml
CleanEx	HS_SLC11A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC11A2
DIP	DIP-48957N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48957N
DOI	10.1002/cbin.10403	http://dx.doi.org/10.1002/cbin.10403
DOI	10.1006/bbrc.1998.9415	http://dx.doi.org/10.1006/bbrc.1998.9415
DOI	10.1006/bcmd.1998.0186	http://dx.doi.org/10.1006/bcmd.1998.0186
DOI	10.1007/BF00352405	http://dx.doi.org/10.1007/BF00352405
DOI	10.1016/S0161-5890(97)00110-7	http://dx.doi.org/10.1016/S0161-5890(97)00110-7
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/nm1542	http://dx.doi.org/10.1038/nm1542
DOI	10.1038/nsmb.2904	http://dx.doi.org/10.1038/nsmb.2904
DOI	10.1042/BJ20061290	http://dx.doi.org/10.1042/BJ20061290
DOI	10.1073/pnas.0904880106	http://dx.doi.org/10.1073/pnas.0904880106
DOI	10.1073/pnas.192423399	http://dx.doi.org/10.1073/pnas.192423399
DOI	10.1091/mbc.E02-03-0165	http://dx.doi.org/10.1091/mbc.E02-03-0165
DOI	10.1096/fj.13-240564	http://dx.doi.org/10.1096/fj.13-240564
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1182/blood-2004-07-2966	http://dx.doi.org/10.1182/blood-2004-07-2966
DOI	10.1182/blood-2005-06-2477	http://dx.doi.org/10.1182/blood-2005-06-2477
DOI	10.1182/blood-2005-10-4269	http://dx.doi.org/10.1182/blood-2005-10-4269
DOI	10.1182/blood-2008-04-150953	http://dx.doi.org/10.1182/blood-2008-04-150953
EMBL	AB004857	http://www.ebi.ac.uk/ena/data/view/AB004857
EMBL	AB015355	http://www.ebi.ac.uk/ena/data/view/AB015355
EMBL	AB062284	http://www.ebi.ac.uk/ena/data/view/AB062284
EMBL	AC087884	http://www.ebi.ac.uk/ena/data/view/AC087884
EMBL	AF046997	http://www.ebi.ac.uk/ena/data/view/AF046997
EMBL	AF064476	http://www.ebi.ac.uk/ena/data/view/AF064476
EMBL	AF064476	http://www.ebi.ac.uk/ena/data/view/AF064476
EMBL	AF064477	http://www.ebi.ac.uk/ena/data/view/AF064477
EMBL	AF064477	http://www.ebi.ac.uk/ena/data/view/AF064477
EMBL	AF064478	http://www.ebi.ac.uk/ena/data/view/AF064478
EMBL	AF064478	http://www.ebi.ac.uk/ena/data/view/AF064478
EMBL	AF064479	http://www.ebi.ac.uk/ena/data/view/AF064479
EMBL	AF064479	http://www.ebi.ac.uk/ena/data/view/AF064479
EMBL	AF064480	http://www.ebi.ac.uk/ena/data/view/AF064480
EMBL	AF064480	http://www.ebi.ac.uk/ena/data/view/AF064480
EMBL	AF064481	http://www.ebi.ac.uk/ena/data/view/AF064481
EMBL	AF064481	http://www.ebi.ac.uk/ena/data/view/AF064481
EMBL	AF064482	http://www.ebi.ac.uk/ena/data/view/AF064482
EMBL	AF064482	http://www.ebi.ac.uk/ena/data/view/AF064482
EMBL	AF064483	http://www.ebi.ac.uk/ena/data/view/AF064483
EMBL	AF064484	http://www.ebi.ac.uk/ena/data/view/AF064484
EMBL	AJ493662	http://www.ebi.ac.uk/ena/data/view/AJ493662
EMBL	AK094735	http://www.ebi.ac.uk/ena/data/view/AK094735
EMBL	AK296445	http://www.ebi.ac.uk/ena/data/view/AK296445
EMBL	AK316507	http://www.ebi.ac.uk/ena/data/view/AK316507
EMBL	BC002592	http://www.ebi.ac.uk/ena/data/view/BC002592
EMBL	BC100014	http://www.ebi.ac.uk/ena/data/view/BC100014
EMBL	CH471111	http://www.ebi.ac.uk/ena/data/view/CH471111
EMBL	L37347	http://www.ebi.ac.uk/ena/data/view/L37347
Ensembl	ENST00000262051	http://www.ensembl.org/id/ENST00000262051
Ensembl	ENST00000262052	http://www.ensembl.org/id/ENST00000262052
Ensembl	ENST00000394904	http://www.ensembl.org/id/ENST00000394904
Ensembl	ENST00000541174	http://www.ensembl.org/id/ENST00000541174
Ensembl	ENST00000545993	http://www.ensembl.org/id/ENST00000545993
Ensembl	ENST00000546636	http://www.ensembl.org/id/ENST00000546636
Ensembl	ENST00000547198	http://www.ensembl.org/id/ENST00000547198
Ensembl	ENST00000547688	http://www.ensembl.org/id/ENST00000547688
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005741	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005741
GO_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005769	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005769
GO_component	GO:0005770	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005770
GO_component	GO:0005773	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005773
GO_component	GO:0005802	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005802
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GO_component	GO:0031526	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031526
GO_component	GO:0031902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031902
GO_component	GO:0045177	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045177
GO_component	GO:0045178	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045178
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_component	GO:0055037	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055037
GO_component	GO:0070826	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070826
GO_function	GO:0005375	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005375
GO_function	GO:0005381	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005381
GO_function	GO:0005384	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005384
GO_function	GO:0005385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005385
GO_function	GO:0015078	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015078
GO_function	GO:0015086	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015086
GO_function	GO:0015087	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015087
GO_function	GO:0015093	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015093
GO_function	GO:0015094	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015094
GO_function	GO:0015099	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015099
GO_function	GO:0015100	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015100
GO_function	GO:0015295	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015295
GO_function	GO:0015639	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015639
GO_function	GO:0022890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022890
GO_function	GO:0046870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046870
GO_function	GO:0046915	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046915
GO_process	GO:0001666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001666
GO_process	GO:0003032	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003032
GO_process	GO:0006783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006783
GO_process	GO:0006824	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006824
GO_process	GO:0006825	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006825
GO_process	GO:0006828	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006828
GO_process	GO:0006879	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006879
GO_process	GO:0006919	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006919
GO_process	GO:0007611	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007611
GO_process	GO:0010039	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010039
GO_process	GO:0015675	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015675
GO_process	GO:0015676	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015676
GO_process	GO:0015684	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015684
GO_process	GO:0015692	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015692
GO_process	GO:0034599	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034599
GO_process	GO:0048813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048813
GO_process	GO:0048821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048821
GO_process	GO:0060586	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060586
GO_process	GO:0070574	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070574
GO_process	GO:0070627	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070627
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005773	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005773
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0051186	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC11A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC11A2
GeneID	4891	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4891
GeneTree	ENSGT00390000006526	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000006526
HAMAP	MF_00221	http://hamap.expasy.org/unirule/MF_00221
HGNC	HGNC:10908	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10908
HOVERGEN	HBG052665	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052665&db=HOVERGEN
HPA	HPA032139	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA032139
HPA	HPA032140	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA032140
InParanoid	P49281	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P49281
IntAct	P49281	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P49281*
InterPro	IPR001046	http://www.ebi.ac.uk/interpro/entry/IPR001046
Jabion	4891	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=4891
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H01196	http://www.genome.jp/dbget-bin/www_bget?H01196
KEGG_Gene	hsa:4891	http://www.genome.jp/dbget-bin/www_bget?hsa:4891
KEGG_Orthology	KO:K12347	http://www.genome.jp/dbget-bin/www_bget?KO:K12347
KEGG_Pathway	ko04142	http://www.genome.jp/kegg-bin/show_pathway?ko04142
KEGG_Pathway	ko04978	http://www.genome.jp/kegg-bin/show_pathway?ko04978
MIM	206100	http://www.ncbi.nlm.nih.gov/omim/206100
MIM	600523	http://www.ncbi.nlm.nih.gov/omim/600523
OMA	ERYSATK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ERYSATK
Orphanet	83642	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=83642
OrthoDB	EOG091G05M9	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05M9
PRINTS	PR00447	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00447
PSORT	swissprot:NRAM2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NRAM2_HUMAN
PSORT-B	swissprot:NRAM2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NRAM2_HUMAN
PSORT2	swissprot:NRAM2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NRAM2_HUMAN
Pfam	PF01566	http://pfam.xfam.org/family/PF01566
PharmGKB	PA259	http://www.pharmgkb.org/do/serve?objId=PA259&objCls=Gene
Phobius	swissprot:NRAM2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NRAM2_HUMAN
PhylomeDB	P49281	http://phylomedb.org/?seqid=P49281
ProteinModelPortal	P49281	http://www.proteinmodelportal.org/query/uniprot/P49281
PubMed	12209011	http://www.ncbi.nlm.nih.gov/pubmed/12209011
PubMed	12475959	http://www.ncbi.nlm.nih.gov/pubmed/12475959
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15459009	http://www.ncbi.nlm.nih.gov/pubmed/15459009
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16160008	http://www.ncbi.nlm.nih.gov/pubmed/16160008
PubMed	16439678	http://www.ncbi.nlm.nih.gov/pubmed/16439678
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	17109629	http://www.ncbi.nlm.nih.gov/pubmed/17109629
PubMed	17293870	http://www.ncbi.nlm.nih.gov/pubmed/17293870
PubMed	18776082	http://www.ncbi.nlm.nih.gov/pubmed/18776082
PubMed	19706893	http://www.ncbi.nlm.nih.gov/pubmed/19706893
PubMed	24448823	http://www.ncbi.nlm.nih.gov/pubmed/24448823
PubMed	25326704	http://www.ncbi.nlm.nih.gov/pubmed/25326704
PubMed	25491917	http://www.ncbi.nlm.nih.gov/pubmed/25491917
PubMed	7613023	http://www.ncbi.nlm.nih.gov/pubmed/7613023
PubMed	9464519	http://www.ncbi.nlm.nih.gov/pubmed/9464519
PubMed	9642100	http://www.ncbi.nlm.nih.gov/pubmed/9642100
PubMed	9790986	http://www.ncbi.nlm.nih.gov/pubmed/9790986
Reactome	R-HSA-425410	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425410
Reactome	R-HSA-917937	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917937
RefSeq	NP_000608	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000608
RefSeq	NP_001167596	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001167596
RefSeq	NP_001167597	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001167597
RefSeq	NP_001167598	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001167598
RefSeq	NP_001167599	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001167599
RefSeq	NP_001167600	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001167600
RefSeq	NP_001167601	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001167601
RefSeq	XP_005268968	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005268968
RefSeq	XP_011536706	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011536706
RefSeq	XP_011536707	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011536707
RefSeq	XP_016874844	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016874844
STRING	9606.ENSP00000378364	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000378364&targetmode=cogs
TCDB	2.A.55.2	http://www.tcdb.org/search/result.php?tc=2.A.55.2
TIGRFAMs	TIGR01197	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01197
UCSC	uc001rxc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001rxc&org=rat
UniGene	Hs.505545	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.505545
UniProtKB	NRAM2_HUMAN	http://www.uniprot.org/uniprot/NRAM2_HUMAN
UniProtKB-AC	P49281	http://www.uniprot.org/uniprot/P49281
charge	swissprot:NRAM2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NRAM2_HUMAN
eggNOG	COG1914	http://eggnogapi.embl.de/nog_data/html/tree/COG1914
eggNOG	KOG1291	http://eggnogapi.embl.de/nog_data/html/tree/KOG1291
epestfind	swissprot:NRAM2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NRAM2_HUMAN
garnier	swissprot:NRAM2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NRAM2_HUMAN
helixturnhelix	swissprot:NRAM2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NRAM2_HUMAN
hmoment	swissprot:NRAM2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NRAM2_HUMAN
iep	swissprot:NRAM2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NRAM2_HUMAN
inforesidue	swissprot:NRAM2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NRAM2_HUMAN
neXtProt	NX_P49281	http://www.nextprot.org/db/entry/NX_P49281
octanol	swissprot:NRAM2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NRAM2_HUMAN
pepcoil	swissprot:NRAM2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NRAM2_HUMAN
pepdigest	swissprot:NRAM2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NRAM2_HUMAN
pepinfo	swissprot:NRAM2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NRAM2_HUMAN
pepnet	swissprot:NRAM2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NRAM2_HUMAN
pepstats	swissprot:NRAM2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NRAM2_HUMAN
pepwheel	swissprot:NRAM2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NRAM2_HUMAN
pepwindow	swissprot:NRAM2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NRAM2_HUMAN
sigcleave	swissprot:NRAM2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NRAM2_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNG2_HUMAN	Cardiac potassium channel subunit
# AltName	KCNG2_HUMAN	Voltage-gated potassium channel subunit Kv6.2
# DOMAIN	KCNG2_HUMAN	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. 
# Ensembl	ENST00000316249	ENSP00000315654; ENSG00000178342
# FUNCTION	KCNG2_HUMAN	Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008076	voltage-gated potassium channel complex; TAS:ProtInc.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; TAS:ProtInc.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0008016	regulation of heart contraction; TAS:ProtInc.
# GO_process	GO:0050796	regulation of insulin secretion; TAS:Reactome.
# GO_process	GO:0051260	protein homooligomerization; IEA:InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.20.120.350	-; 1.
# Genevisible	Q9UJ96	HS
# HGNC	HGNC:6249	KCNG2
# InterPro	IPR000210	BTB/POZ_dom
# InterPro	IPR003131	T1-type_BTB
# InterPro	IPR003968	K_chnl_volt-dep_Kv
# InterPro	IPR003969	K_chnl_volt-dep_Kv6
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR011333	SKP1/BTB/POZ
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko04040	Ion channels
# MIM	605696	gene
# MISCELLANEOUS	KCNG2_HUMAN	Heterodimers with KCNB1 are highly sensitive to inhibition by tetraethylammonium (TEA) and propafenone. 
# Organism	KCNG2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11537	PTHR11537
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01491	KVCHANNEL
# PRINTS	PR01492	KV6CHANNEL
# Pfam	PF00520	Ion_trans
# Pfam	PF02214	BTB_2
# Proteomes	UP000005640	Chromosome 18
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# Reactome	R-HSA-381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
# RecName	KCNG2_HUMAN	Potassium voltage-gated channel subfamily G member 2
# RefSeq	NP_036415	NM_012283.1
# RefSeq	XP_011524220	XM_011525918.2
# RefSeq	XP_011524222	XM_011525920.2
# RefSeq	XP_016881194	XM_017025705.1
# SIMILARITY	Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.2/KCNG2 sub-subfamily. {ECO	0000305}.
# SMART	SM00225	BTB
# SUBCELLULAR LOCATION	KCNG2_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	KCNG2_HUMAN	Heterodimer with KCNB1. Does not form homomultimers. 
# SUPFAM	SSF54695	SSF54695
# TISSUE SPECIFICITY	KCNG2_HUMAN	Highly expressed in heart, liver, skeletal muscle, kidney and pancreas. Detected at low levels in brain, lung and placenta. 
# UCSC	uc010xfl	human
# eggNOG	COG1226	LUCA
# eggNOG	KOG3713	Eukaryota
BLAST	swissprot:KCNG2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNG2_HUMAN
BioCyc	ZFISH:ENSG00000178342-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000178342-MONOMER
COXPRESdb	26251	http://coxpresdb.jp/data/gene/26251.shtml
CleanEx	HS_KCNG2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNG2
EMBL	AJ011021	http://www.ebi.ac.uk/ena/data/view/AJ011021
Ensembl	ENST00000316249	http://www.ensembl.org/id/ENST00000316249
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0008016	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008016
GO_process	GO:0050796	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050796
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	KCNG2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNG2
GeneID	26251	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26251
GeneTree	ENSGT00760000118981	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118981
HGNC	HGNC:6249	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6249
HOGENOM	HOG000231014	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231014&db=HOGENOM6
HOVERGEN	HBG100172	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG100172&db=HOVERGEN
HPA	HPA048628	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA048628
InParanoid	Q9UJ96	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UJ96
InterPro	IPR000210	http://www.ebi.ac.uk/interpro/entry/IPR000210
InterPro	IPR003131	http://www.ebi.ac.uk/interpro/entry/IPR003131
InterPro	IPR003968	http://www.ebi.ac.uk/interpro/entry/IPR003968
InterPro	IPR003969	http://www.ebi.ac.uk/interpro/entry/IPR003969
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR011333	http://www.ebi.ac.uk/interpro/entry/IPR011333
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	26251	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=26251
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:26251	http://www.genome.jp/dbget-bin/www_bget?hsa:26251
KEGG_Orthology	KO:K04901	http://www.genome.jp/dbget-bin/www_bget?KO:K04901
MIM	605696	http://www.ncbi.nlm.nih.gov/omim/605696
OMA	SETTQCA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SETTQCA
OrthoDB	EOG091G0DSU	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0DSU
PANTHER	PTHR11537	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01491	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01491
PRINTS	PR01492	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01492
PSORT	swissprot:KCNG2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNG2_HUMAN
PSORT-B	swissprot:KCNG2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNG2_HUMAN
PSORT2	swissprot:KCNG2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNG2_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF02214	http://pfam.xfam.org/family/PF02214
PharmGKB	PA30035	http://www.pharmgkb.org/do/serve?objId=PA30035&objCls=Gene
Phobius	swissprot:KCNG2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNG2_HUMAN
PhylomeDB	Q9UJ96	http://phylomedb.org/?seqid=Q9UJ96
ProteinModelPortal	Q9UJ96	http://www.proteinmodelportal.org/query/uniprot/Q9UJ96
PubMed	10551266	http://www.ncbi.nlm.nih.gov/pubmed/10551266
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
Reactome	R-HSA-381676	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-381676
RefSeq	NP_036415	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_036415
RefSeq	XP_011524220	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011524220
RefSeq	XP_011524222	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011524222
RefSeq	XP_016881194	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016881194
SMART	SM00225	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225
SMR	Q9UJ96	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9UJ96
STRING	9606.ENSP00000315654	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000315654&targetmode=cogs
SUPFAM	SSF54695	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54695
UCSC	uc010xfl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010xfl&org=rat
UniGene	Hs.247905	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.247905
UniProtKB	KCNG2_HUMAN	http://www.uniprot.org/uniprot/KCNG2_HUMAN
UniProtKB-AC	Q9UJ96	http://www.uniprot.org/uniprot/Q9UJ96
charge	swissprot:KCNG2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNG2_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG3713	http://eggnogapi.embl.de/nog_data/html/tree/KOG3713
epestfind	swissprot:KCNG2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNG2_HUMAN
garnier	swissprot:KCNG2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNG2_HUMAN
helixturnhelix	swissprot:KCNG2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNG2_HUMAN
hmoment	swissprot:KCNG2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNG2_HUMAN
iep	swissprot:KCNG2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNG2_HUMAN
inforesidue	swissprot:KCNG2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNG2_HUMAN
neXtProt	NX_Q9UJ96	http://www.nextprot.org/db/entry/NX_Q9UJ96
octanol	swissprot:KCNG2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNG2_HUMAN
pepcoil	swissprot:KCNG2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNG2_HUMAN
pepdigest	swissprot:KCNG2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNG2_HUMAN
pepinfo	swissprot:KCNG2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNG2_HUMAN
pepnet	swissprot:KCNG2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNG2_HUMAN
pepstats	swissprot:KCNG2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNG2_HUMAN
pepwheel	swissprot:KCNG2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNG2_HUMAN
pepwindow	swissprot:KCNG2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNG2_HUMAN
sigcleave	swissprot:KCNG2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNG2_HUMAN
## Database	ID	URL or Descriptions
# AltName	SL9A9_HUMAN	Na(+)/H(+) exchanger 9
# AltName	SL9A9_HUMAN	Solute carrier family 9 member 9
# ChiTaRS	SLC9A9	human
# DISEASE	SL9A9_HUMAN	Autism 16 (AUTS16) [MIM 613410]  A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. AUTS16 can be associated with epilepsy. {ECO 0000269|PubMed 18621663}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# DISEASE	SL9A9_HUMAN	Note=A chromosomal aberration involving SLC9A9 has been found in a family with early-onset behavioral/developmental disorder with features of attention deficit-hyperactivity disorder and intellectual disability. Inversion inv(3)(p14 q21). The inversion disrupts DOCK3 and SLC9A9. 
# Ensembl	ENST00000316549	ENSP00000320246; ENSG00000181804
# ExpressionAtlas	Q8IVB4	baseline and differential
# FUNCTION	SL9A9_HUMAN	May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell. {ECO 0000269|PubMed 15522866}. 
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0031902	late endosome membrane; TAS:Reactome.
# GO_component	GO:0055037	recycling endosome; IDA:UniProtKB.
# GO_function	SL9A9_HUMAN	GO 0015385 sodium proton antiporter activity; IBA GO_Central.
# GO_function	SL9A9_HUMAN	GO 0015386 potassium proton antiporter activity; IBA GO_Central.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0051453	regulation of intracellular pH; IBA:GO_Central.
# GO_process	GO:0071805	potassium ion transmembrane transport; IBA:GO_Central.
# GO_process	GO:0098719	sodium ion import across plasma membrane; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q8IVB4	HS
# HGNC	HGNC:20653	SLC9A9
# INTERACTION	SL9A9_HUMAN	Q8IUH5 ZDHHC17; NbExp=2; IntAct=EBI-9092184, EBI-524753; 
# InterPro	IPR002090	Na/H_exchanger_6
# InterPro	IPR004709	NaH_exchanger
# InterPro	IPR006153	Cation/H_exchanger
# InterPro	IPR018416	Na/H_exchanger_9
# InterPro	IPR018422	Cation/H_exchanger_CPA1
# KEGG_Brite	ko02001	Solute carrier family
# MIM	608396	gene
# MIM	613410	phenotype
# Organism	SL9A9_HUMAN	Homo sapiens (Human)
# Orphanet	106	Autism
# PANTHER	PTHR10110	PTHR10110; 2
# PANTHER	PTHR10110:SF61	PTHR10110:SF61; 2
# PRINTS	PR01084	NAHEXCHNGR
# PRINTS	PR01088	NAHEXCHNGR6
# Pfam	PF00999	Na_H_Exchanger
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-425986	Sodium/Proton exchangers
# RecName	SL9A9_HUMAN	Sodium/hydrogen exchanger 9
# RefSeq	NP_775924	NM_173653.3
# SEQUENCE CAUTION	Sequence=BAC04005.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	SL9A9_HUMAN	Late endosome membrane {ECO 0000269|PubMed 15522866}; Multi-pass membrane protein {ECO 0000269|PubMed 15522866}. 
# TCDB	2.A.36.1.19:the monovalent cation	proton antiporter-1 (cpa1) family
# TIGRFAMs	TIGR00840	b_cpa1
# TISSUE SPECIFICITY	SL9A9_HUMAN	Ubiquitously expressed in all tissues tested. Expressed at highest levels in heart and skeletal muscle, followed by placenta, kidney, and liver. Expressed in the brain, in the medulla and spinal cord. {ECO 0000269|PubMed 14569117, ECO 0000269|PubMed 15522866}. 
# UCSC	uc003evn	human
# eggNOG	COG0025	LUCA
# eggNOG	KOG1965	Eukaryota
BLAST	swissprot:SL9A9_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SL9A9_HUMAN
COXPRESdb	285195	http://coxpresdb.jp/data/gene/285195.shtml
CleanEx	HS_SLC9A9	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC9A9
DOI	10.1016/S0304-3835(03)00085-5	http://dx.doi.org/10.1016/S0304-3835(03)00085-5
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M410041200	http://dx.doi.org/10.1074/jbc.M410041200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1157657	http://dx.doi.org/10.1126/science.1157657
DOI	10.1136/jmg.40.10.733	http://dx.doi.org/10.1136/jmg.40.10.733
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AB075486	http://www.ebi.ac.uk/ena/data/view/AB075486
EMBL	AB089794	http://www.ebi.ac.uk/ena/data/view/AB089794
EMBL	AC131210	http://www.ebi.ac.uk/ena/data/view/AC131210
EMBL	AK092932	http://www.ebi.ac.uk/ena/data/view/AK092932
EMBL	AL832304	http://www.ebi.ac.uk/ena/data/view/AL832304
EMBL	AY254100	http://www.ebi.ac.uk/ena/data/view/AY254100
EMBL	BC035779	http://www.ebi.ac.uk/ena/data/view/BC035779
Ensembl	ENST00000316549	http://www.ensembl.org/id/ENST00000316549
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0031902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031902
GO_component	GO:0055037	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055037
GO_function	GO:0015385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015385
GO_function	GO:0015386	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015386
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GO_process	GO:0098719	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098719
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC9A9	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC9A9
GeneID	285195	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=285195
GeneTree	ENSGT00760000119074	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119074
HGNC	HGNC:20653	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20653
HOGENOM	HOG000172307	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000172307&db=HOGENOM6
HOVERGEN	HBG055575	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG055575&db=HOVERGEN
HPA	HPA058234	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA058234
InParanoid	Q8IVB4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8IVB4
IntAct	Q8IVB4	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8IVB4*
InterPro	IPR002090	http://www.ebi.ac.uk/interpro/entry/IPR002090
InterPro	IPR004709	http://www.ebi.ac.uk/interpro/entry/IPR004709
InterPro	IPR006153	http://www.ebi.ac.uk/interpro/entry/IPR006153
InterPro	IPR018416	http://www.ebi.ac.uk/interpro/entry/IPR018416
InterPro	IPR018422	http://www.ebi.ac.uk/interpro/entry/IPR018422
Jabion	285195	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=285195
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:285195	http://www.genome.jp/dbget-bin/www_bget?hsa:285195
KEGG_Orthology	KO:K14725	http://www.genome.jp/dbget-bin/www_bget?KO:K14725
MIM	608396	http://www.ncbi.nlm.nih.gov/omim/608396
MIM	613410	http://www.ncbi.nlm.nih.gov/omim/613410
OMA	NPHQGNA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NPHQGNA
Orphanet	106	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=106
OrthoDB	EOG091G0HN5	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0HN5
PANTHER	PTHR10110	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10110
PANTHER	PTHR10110:SF61	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10110:SF61
PRINTS	PR01084	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01084
PRINTS	PR01088	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01088
PSORT	swissprot:SL9A9_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SL9A9_HUMAN
PSORT-B	swissprot:SL9A9_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SL9A9_HUMAN
PSORT2	swissprot:SL9A9_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SL9A9_HUMAN
Pfam	PF00999	http://pfam.xfam.org/family/PF00999
PharmGKB	PA134889062	http://www.pharmgkb.org/do/serve?objId=PA134889062&objCls=Gene
Phobius	swissprot:SL9A9_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SL9A9_HUMAN
PhylomeDB	Q8IVB4	http://phylomedb.org/?seqid=Q8IVB4
ProteinModelPortal	Q8IVB4	http://www.proteinmodelportal.org/query/uniprot/Q8IVB4
PubMed	12880961	http://www.ncbi.nlm.nih.gov/pubmed/12880961
PubMed	14569117	http://www.ncbi.nlm.nih.gov/pubmed/14569117
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15522866	http://www.ncbi.nlm.nih.gov/pubmed/15522866
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18621663	http://www.ncbi.nlm.nih.gov/pubmed/18621663
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
Reactome	R-HSA-425986	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425986
RefSeq	NP_775924	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_775924
SMR	Q8IVB4	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8IVB4
STRING	9606.ENSP00000320246	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000320246&targetmode=cogs
TCDB	2.A.36.1.19	http://www.tcdb.org/search/result.php?tc=2.A.36.1.19
TIGRFAMs	TIGR00840	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00840
UCSC	uc003evn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003evn&org=rat
UniGene	Hs.302257	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.302257
UniProtKB	SL9A9_HUMAN	http://www.uniprot.org/uniprot/SL9A9_HUMAN
UniProtKB-AC	Q8IVB4	http://www.uniprot.org/uniprot/Q8IVB4
charge	swissprot:SL9A9_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SL9A9_HUMAN
eggNOG	COG0025	http://eggnogapi.embl.de/nog_data/html/tree/COG0025
eggNOG	KOG1965	http://eggnogapi.embl.de/nog_data/html/tree/KOG1965
epestfind	swissprot:SL9A9_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SL9A9_HUMAN
garnier	swissprot:SL9A9_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SL9A9_HUMAN
helixturnhelix	swissprot:SL9A9_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SL9A9_HUMAN
hmoment	swissprot:SL9A9_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SL9A9_HUMAN
iep	swissprot:SL9A9_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SL9A9_HUMAN
inforesidue	swissprot:SL9A9_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SL9A9_HUMAN
neXtProt	NX_Q8IVB4	http://www.nextprot.org/db/entry/NX_Q8IVB4
octanol	swissprot:SL9A9_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SL9A9_HUMAN
pepcoil	swissprot:SL9A9_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SL9A9_HUMAN
pepdigest	swissprot:SL9A9_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SL9A9_HUMAN
pepinfo	swissprot:SL9A9_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SL9A9_HUMAN
pepnet	swissprot:SL9A9_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SL9A9_HUMAN
pepstats	swissprot:SL9A9_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SL9A9_HUMAN
pepwheel	swissprot:SL9A9_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SL9A9_HUMAN
pepwindow	swissprot:SL9A9_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SL9A9_HUMAN
sigcleave	swissprot:SL9A9_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SL9A9_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S39A3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BRY0-1; Sequence=Displayed; Name=2; IsoId=Q9BRY0-2; Sequence=VSP_029920, VSP_029921; 
# AltName	S39A3_HUMAN	Solute carrier family 39 member 3
# AltName	S39A3_HUMAN	Zrt- and Irt-like protein 3
# BioGrid	119011	8
# CCDS	CCDS12093	-. [Q9BRY0-1]
# CCDS	CCDS45909	-. [Q9BRY0-2]
# ChiTaRS	SLC39A3	human
# Ensembl	ENST00000269740	ENSP00000269740; ENSG00000141873. [Q9BRY0-1]
# Ensembl	ENST00000455372	ENSP00000393715; ENSG00000141873. [Q9BRY0-2]
# ExpressionAtlas	Q9BRY0	baseline and differential
# FUNCTION	S39A3_HUMAN	Acts as a zinc-influx transporter. {ECO 0000305}. 
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005385	zinc ion transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0000902	cell morphogenesis; IEA:Ensembl.
# GO_process	GO:0001701	in utero embryonic development; IEA:Ensembl.
# GO_process	GO:0043029	T cell homeostasis; IEA:Ensembl.
# GO_process	GO:0048701	embryonic cranial skeleton morphogenesis; IEA:Ensembl.
# GO_process	GO:0060173	limb development; IEA:Ensembl.
# GO_process	GO:0071577	zinc II ion transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0000902	cell morphogenesis
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009790	embryo development
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9BRY0	HS
# HGNC	HGNC:17128	SLC39A3
# InterPro	IPR003689	ZIP
# KEGG_Brite	ko02001	Solute carrier family
# MIM	612168	gene
# Organism	S39A3_HUMAN	Homo sapiens (Human)
# Pfam	PF02535	Zip
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-442380	Zinc influx into cells by the SLC39 gene family
# RecName	S39A3_HUMAN	Zinc transporter ZIP3
# RefSeq	NP_653165	NM_144564.4. [Q9BRY0-1]
# RefSeq	NP_998733	NM_213568.1. [Q9BRY0-2]
# SIMILARITY	Belongs to the ZIP transporter (TC 2.A.5) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S39A3_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	2.A.5.3	the zinc (zn(2+))-iron (fe(2+)) permease (zip) family
# UCSC	uc002lwg	human. [Q9BRY0-1]
# eggNOG	ENOG4111GP2	LUCA
# eggNOG	KOG1558	Eukaryota
BLAST	swissprot:S39A3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S39A3_HUMAN
BioCyc	ZFISH:ENSG00000141873-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000141873-MONOMER
COXPRESdb	29985	http://coxpresdb.jp/data/gene/29985.shtml
CleanEx	HS_SLC39A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC39A3
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
EMBL	AK002044	http://www.ebi.ac.uk/ena/data/view/AK002044
EMBL	BC005869	http://www.ebi.ac.uk/ena/data/view/BC005869
EMBL	BC020571	http://www.ebi.ac.uk/ena/data/view/BC020571
Ensembl	ENST00000269740	http://www.ensembl.org/id/ENST00000269740
Ensembl	ENST00000455372	http://www.ensembl.org/id/ENST00000455372
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005385
GO_process	GO:0000902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000902
GO_process	GO:0001701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001701
GO_process	GO:0043029	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043029
GO_process	GO:0048701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048701
GO_process	GO:0060173	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060173
GO_process	GO:0071577	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071577
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0000902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000902
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009790
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC39A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC39A3
GeneID	29985	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29985
GeneTree	ENSGT00530000063242	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063242
HGNC	HGNC:17128	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17128
HOVERGEN	HBG108447	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108447&db=HOVERGEN
HPA	HPA042139	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042139
HPA	HPA058526	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA058526
InParanoid	Q9BRY0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9BRY0
InterPro	IPR003689	http://www.ebi.ac.uk/interpro/entry/IPR003689
Jabion	29985	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=29985
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:29985	http://www.genome.jp/dbget-bin/www_bget?hsa:29985
KEGG_Orthology	KO:K14709	http://www.genome.jp/dbget-bin/www_bget?KO:K14709
MIM	612168	http://www.ncbi.nlm.nih.gov/omim/612168
PSORT	swissprot:S39A3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S39A3_HUMAN
PSORT-B	swissprot:S39A3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S39A3_HUMAN
PSORT2	swissprot:S39A3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S39A3_HUMAN
Pfam	PF02535	http://pfam.xfam.org/family/PF02535
PharmGKB	PA38203	http://www.pharmgkb.org/do/serve?objId=PA38203&objCls=Gene
Phobius	swissprot:S39A3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S39A3_HUMAN
PhylomeDB	Q9BRY0	http://phylomedb.org/?seqid=Q9BRY0
ProteinModelPortal	Q9BRY0	http://www.proteinmodelportal.org/query/uniprot/Q9BRY0
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
Reactome	R-HSA-442380	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442380
RefSeq	NP_653165	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_653165
RefSeq	NP_998733	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_998733
STRING	9606.ENSP00000269740	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000269740&targetmode=cogs
TCDB	2.A.5.3	http://www.tcdb.org/search/result.php?tc=2.A.5.3
UCSC	uc002lwg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002lwg&org=rat
UniGene	Hs.515046	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.515046
UniProtKB	S39A3_HUMAN	http://www.uniprot.org/uniprot/S39A3_HUMAN
UniProtKB-AC	Q9BRY0	http://www.uniprot.org/uniprot/Q9BRY0
charge	swissprot:S39A3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S39A3_HUMAN
eggNOG	ENOG4111GP2	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111GP2
eggNOG	KOG1558	http://eggnogapi.embl.de/nog_data/html/tree/KOG1558
epestfind	swissprot:S39A3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S39A3_HUMAN
garnier	swissprot:S39A3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S39A3_HUMAN
helixturnhelix	swissprot:S39A3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S39A3_HUMAN
hmoment	swissprot:S39A3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S39A3_HUMAN
iep	swissprot:S39A3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S39A3_HUMAN
inforesidue	swissprot:S39A3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S39A3_HUMAN
neXtProt	NX_Q9BRY0	http://www.nextprot.org/db/entry/NX_Q9BRY0
octanol	swissprot:S39A3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S39A3_HUMAN
pepcoil	swissprot:S39A3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S39A3_HUMAN
pepdigest	swissprot:S39A3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S39A3_HUMAN
pepinfo	swissprot:S39A3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S39A3_HUMAN
pepnet	swissprot:S39A3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S39A3_HUMAN
pepstats	swissprot:S39A3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S39A3_HUMAN
pepwheel	swissprot:S39A3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S39A3_HUMAN
pepwindow	swissprot:S39A3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S39A3_HUMAN
sigcleave	swissprot:S39A3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S39A3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	DEN5B_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q6ZUT9-1; Sequence=Displayed; Name=2; IsoId=Q6ZUT9-2; Sequence=VSP_032673; Name=3; IsoId=Q6ZUT9-3; Sequence=VSP_032672, VSP_032675, VSP_032676; Name=4; IsoId=Q6ZUT9-4; Sequence=VSP_032674, VSP_032677, VSP_032678; 
# AltName	DEN5B_HUMAN	Rab6IP1-like protein
# BioGrid	127761	3
# CCDS	CCDS44857	-. [Q6ZUT9-1]
# CCDS	CCDS76542	-. [Q6ZUT9-2]
# ChiTaRS	DENND5B	human
# Ensembl	ENST00000354285	ENSP00000346238; ENSG00000170456. [Q6ZUT9-4]
# Ensembl	ENST00000389082	ENSP00000373734; ENSG00000170456. [Q6ZUT9-1]
# ExpressionAtlas	Q6ZUT9	baseline and differential
# FUNCTION	DEN5B_HUMAN	Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO 0000269|PubMed 20937701}. 
# GO_component	GO:0016020	membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005262	calcium channel activity; IBA:GO_Central.
# GO_function	GO:0017112	Rab guanyl-nucleotide exchange factor activity; IDA:UniProtKB.
# GO_process	GO:0050982	detection of mechanical stimulus; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# Gene3D	2.60.60.20	-; 1.
# Genevisible	Q6ZUT9	HS
# HGNC	HGNC:28338	DENND5B
# InterPro	IPR001024	PLAT/LH2_dom
# InterPro	IPR001194	DENN_dom
# InterPro	IPR004012	Run_dom
# InterPro	IPR005112	dDENN_dom
# InterPro	IPR005113	uDENN_dom
# Organism	DEN5B_HUMAN	Homo sapiens (Human)
# PROSITE	PS50095	PLAT
# PROSITE	PS50211	DENN
# PROSITE	PS50826	RUN; 2
# PROSITE	PS50946	UDENN
# PROSITE	PS50947	DDENN
# Pfam	PF01477	PLAT
# Pfam	PF02141	DENN
# Pfam	PF02759	RUN; 2
# Pfam	PF03455	dDENN
# Pfam	PF03456	uDENN
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-8876198	RAB GEFs exchange GTP for GDP on RABs
# RecName	DEN5B_HUMAN	DENN domain-containing protein 5B
# RefSeq	NP_001295268	NM_001308339.1
# RefSeq	NP_659410	NM_144973.3. [Q6ZUT9-1]
# SEQUENCE CAUTION	Sequence=BAC04583.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the RAB6IP1 family. {ECO	0000305}. 
# SIMILARITY	Contains 1 DENN domain. {ECO:0000255|PROSITE- ProRule	PRU00304}. 
# SIMILARITY	Contains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule	PRU00152}. 
# SIMILARITY	Contains 1 dDENN domain. {ECO:0000255|PROSITE- ProRule	PRU00306}. 
# SIMILARITY	Contains 1 uDENN domain. {ECO:0000255|PROSITE- ProRule	PRU00305}. 
# SIMILARITY	Contains 2 RUN domains. {ECO:0000255|PROSITE- ProRule	PRU00178}. 
# SMART	SM00593	RUN; 2
# SMART	SM00799	DENN
# SMART	SM00800	uDENN
# SMART	SM00801	dDENN
# SUBCELLULAR LOCATION	DEN5B_HUMAN	Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF49723	SSF49723
# UCSC	uc001rki	human. [Q6ZUT9-1]
# eggNOG	ENOG410XNYP	LUCA
# eggNOG	KOG2080	Eukaryota
BLAST	swissprot:DEN5B_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:DEN5B_HUMAN
COXPRESdb	160518	http://coxpresdb.jp/data/gene/160518.shtml
CleanEx	HS_DENND5B	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_DENND5B
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1083/jcb.201008051	http://dx.doi.org/10.1083/jcb.201008051
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AB209341	http://www.ebi.ac.uk/ena/data/view/AB209341
EMBL	AC022080	http://www.ebi.ac.uk/ena/data/view/AC022080
EMBL	AC068792	http://www.ebi.ac.uk/ena/data/view/AC068792
EMBL	AK095598	http://www.ebi.ac.uk/ena/data/view/AK095598
EMBL	AK125323	http://www.ebi.ac.uk/ena/data/view/AK125323
EMBL	BC020855	http://www.ebi.ac.uk/ena/data/view/BC020855
EMBL	BC068580	http://www.ebi.ac.uk/ena/data/view/BC068580
EMBL	BX537924	http://www.ebi.ac.uk/ena/data/view/BX537924
EMBL	CH471116	http://www.ebi.ac.uk/ena/data/view/CH471116
EMBL	CR749639	http://www.ebi.ac.uk/ena/data/view/CR749639
Ensembl	ENST00000354285	http://www.ensembl.org/id/ENST00000354285
Ensembl	ENST00000389082	http://www.ensembl.org/id/ENST00000389082
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0017112	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017112
GO_process	GO:0050982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050982
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	2.60.60.20	http://www.cathdb.info/version/latest/superfamily/2.60.60.20
GeneCards	DENND5B	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=DENND5B
GeneID	160518	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=160518
GeneTree	ENSGT00760000118819	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118819
H-InvDB	HIX0010527	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0010527
HGNC	HGNC:28338	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:28338
HOVERGEN	HBG059906	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG059906&db=HOVERGEN
HPA	HPA038865	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA038865
InParanoid	Q6ZUT9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6ZUT9
InterPro	IPR001024	http://www.ebi.ac.uk/interpro/entry/IPR001024
InterPro	IPR001194	http://www.ebi.ac.uk/interpro/entry/IPR001194
InterPro	IPR004012	http://www.ebi.ac.uk/interpro/entry/IPR004012
InterPro	IPR005112	http://www.ebi.ac.uk/interpro/entry/IPR005112
InterPro	IPR005113	http://www.ebi.ac.uk/interpro/entry/IPR005113
Jabion	160518	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=160518
KEGG_Gene	hsa:160518	http://www.genome.jp/dbget-bin/www_bget?hsa:160518
PROSITE	PS50095	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50095
PROSITE	PS50211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50211
PROSITE	PS50826	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50826
PROSITE	PS50946	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50946
PROSITE	PS50947	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50947
PSORT	swissprot:DEN5B_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:DEN5B_HUMAN
PSORT-B	swissprot:DEN5B_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:DEN5B_HUMAN
PSORT2	swissprot:DEN5B_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:DEN5B_HUMAN
Pfam	PF01477	http://pfam.xfam.org/family/PF01477
Pfam	PF02141	http://pfam.xfam.org/family/PF02141
Pfam	PF02759	http://pfam.xfam.org/family/PF02759
Pfam	PF03455	http://pfam.xfam.org/family/PF03455
Pfam	PF03456	http://pfam.xfam.org/family/PF03456
PharmGKB	PA164718788	http://www.pharmgkb.org/do/serve?objId=PA164718788&objCls=Gene
Phobius	swissprot:DEN5B_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:DEN5B_HUMAN
PhylomeDB	Q6ZUT9	http://phylomedb.org/?seqid=Q6ZUT9
ProteinModelPortal	Q6ZUT9	http://www.proteinmodelportal.org/query/uniprot/Q6ZUT9
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	20937701	http://www.ncbi.nlm.nih.gov/pubmed/20937701
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
Reactome	R-HSA-8876198	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8876198
RefSeq	NP_001295268	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001295268
RefSeq	NP_659410	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_659410
SMART	SM00593	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00593
SMART	SM00799	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00799
SMART	SM00800	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00800
SMART	SM00801	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00801
SMR	Q6ZUT9	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q6ZUT9
STRING	9606.ENSP00000373734	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000373734&targetmode=cogs
SUPFAM	SSF49723	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49723
UCSC	uc001rki	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001rki&org=rat
UniGene	Hs.118166	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.118166
UniProtKB	DEN5B_HUMAN	http://www.uniprot.org/uniprot/DEN5B_HUMAN
UniProtKB-AC	Q6ZUT9	http://www.uniprot.org/uniprot/Q6ZUT9
charge	swissprot:DEN5B_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:DEN5B_HUMAN
eggNOG	ENOG410XNYP	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNYP
eggNOG	KOG2080	http://eggnogapi.embl.de/nog_data/html/tree/KOG2080
epestfind	swissprot:DEN5B_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:DEN5B_HUMAN
garnier	swissprot:DEN5B_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:DEN5B_HUMAN
helixturnhelix	swissprot:DEN5B_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:DEN5B_HUMAN
hmoment	swissprot:DEN5B_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:DEN5B_HUMAN
iep	swissprot:DEN5B_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:DEN5B_HUMAN
inforesidue	swissprot:DEN5B_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:DEN5B_HUMAN
neXtProt	NX_Q6ZUT9	http://www.nextprot.org/db/entry/NX_Q6ZUT9
octanol	swissprot:DEN5B_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:DEN5B_HUMAN
pepcoil	swissprot:DEN5B_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:DEN5B_HUMAN
pepdigest	swissprot:DEN5B_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:DEN5B_HUMAN
pepinfo	swissprot:DEN5B_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:DEN5B_HUMAN
pepnet	swissprot:DEN5B_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:DEN5B_HUMAN
pepstats	swissprot:DEN5B_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:DEN5B_HUMAN
pepwheel	swissprot:DEN5B_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:DEN5B_HUMAN
pepwindow	swissprot:DEN5B_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:DEN5B_HUMAN
sigcleave	swissprot:DEN5B_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:DEN5B_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SERC5_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q86VE9-1; Sequence=Displayed; Name=2; IsoId=Q86VE9-2; Sequence=VSP_033055; Name=3; IsoId=Q86VE9-3; Sequence=VSP_033054; Name=4; IsoId=Q86VE9-4; Sequence=VSP_042310; 
# CCDS	CCDS54874	-. [Q86VE9-4]
# CCDS	CCDS83009	-. [Q86VE9-2]
# ChiTaRS	SERINC5	human
# Ensembl	ENST00000507668	ENSP00000426237; ENSG00000164300. [Q86VE9-4]
# Ensembl	ENST00000509193	ENSP00000426134; ENSG00000164300. [Q86VE9-2]
# Ensembl	ENST00000512972	ENSP00000421665; ENSG00000164300. [Q86VE9-3]
# ExpressionAtlas	Q86VE9	baseline and differential
# FUNCTION	SERC5_HUMAN	Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1  acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed 26416733, PubMed 26416734). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity). {ECO 0000250|UniProtKB Q63175, ECO 0000269|PubMed 26416733, ECO 0000269|PubMed 26416734}. 
# GO_component	GO:0005794	Golgi apparatus; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IBA:GO_Central.
# GO_component	GO:0043209	myelin sheath; IEA:Ensembl.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0015194	L-serine transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0006658	phosphatidylserine metabolic process; ISS:HGNC.
# GO_process	GO:0006665	sphingolipid metabolic process; IEA:InterPro.
# GO_process	GO:0008654	phospholipid biosynthetic process; IEA:UniProtKB-KW.
# GO_process	GO:0009597	detection of virus; IDA:UniProtKB.
# GO_process	GO:0042552	myelination; IEA:Ensembl.
# GO_process	GO:0045087	innate immune response; IDA:UniProtKB.
# GO_process	GO:0051607	defense response to virus; IDA:UniProtKB.
# GO_process	GO:1904219	positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity; ISS:BHF-UCL.
# GO_process	GO:1904222	positive regulation of serine C-palmitoyltransferase activity; ISS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# Genevisible	Q86VE9	HS
# HGNC	HGNC:18825	SERINC5
# InterPro	IPR005016	TDE1/TMS
# InterPro	IPR029555	Serinc5
# MIM	614551	gene
# Organism	SERC5_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10383	PTHR10383
# PANTHER	PTHR10383:SF16	PTHR10383:SF16
# Pfam	PF03348	Serinc
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-977347	Serine biosynthesis
# RecName	Serine incorporator 5 {ECO	0000305}
# RefSeq	NP_001167542	NM_001174071.2. [Q86VE9-2]
# RefSeq	NP_001167543	NM_001174072.2. [Q86VE9-4]
# RefSeq	NP_840060	NM_178276.6. [Q86VE9-1]
# SIMILARITY	Belongs to the TDE1 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	SERC5_HUMAN	Cell membrane {ECO 0000269|PubMed 26416733, ECO 0000269|PubMed 26416734}; Multi-pass membrane protein {ECO 0000255}. 
# SUBCELLULAR LOCATION	SERC5_HUMAN	Cytoplasm, perinuclear region {ECO 0000269|PubMed 26416734, ECO 0000305|PubMed 26416733}. Note=(Microbial infection) Upon HIV-1 infection, it is redirected to perinuclear region following interaction with HIV-1 Nef, excluding it from virions particles, thereby preventing subsequent antiviral defense activity (PubMed 26416733, PubMed 26416734). Localizes to the cell membrane, where it is efficiently incorporated into budding virions and impairs subsequent virion entry into target cells (PubMed 26416733, PubMed 26416734). {ECO 0000269|PubMed 26416734, ECO 0000305|PubMed 26416733}. 
# TISSUE SPECIFICITY	Highly expressed in placenta, skeletal muscle, spleen, thymus, testis and peripheral leukocyte and is expressed weakly in the heart, liver and fetal brain. {ECO:0000269|PubMed	12688535}. 
# UCSC	uc011ctj	human. [Q86VE9-1]
# eggNOG	ENOG410XP7K	LUCA
# eggNOG	KOG2592	Eukaryota
BLAST	swissprot:SERC5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SERC5_HUMAN
COXPRESdb	256987	http://coxpresdb.jp/data/gene/256987.shtml
CleanEx	HS_SERINC5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SERINC5
DIP	DIP-47313N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47313N
DOI	10.1023/A:1022250428015	http://dx.doi.org/10.1023/A:1022250428015
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1038/nature15399	http://dx.doi.org/10.1038/nature15399
DOI	10.1038/nature15400	http://dx.doi.org/10.1038/nature15400
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC010260	http://www.ebi.ac.uk/ena/data/view/AC010260
EMBL	AC012636	http://www.ebi.ac.uk/ena/data/view/AC012636
EMBL	AF498273	http://www.ebi.ac.uk/ena/data/view/AF498273
EMBL	AK297467	http://www.ebi.ac.uk/ena/data/view/AK297467
EMBL	BC101280	http://www.ebi.ac.uk/ena/data/view/BC101280
EMBL	BC101281	http://www.ebi.ac.uk/ena/data/view/BC101281
EMBL	BC101283	http://www.ebi.ac.uk/ena/data/view/BC101283
EMBL	CH471084	http://www.ebi.ac.uk/ena/data/view/CH471084
EMBL	CH471084	http://www.ebi.ac.uk/ena/data/view/CH471084
EMBL	CH471084	http://www.ebi.ac.uk/ena/data/view/CH471084
Ensembl	ENST00000507668	http://www.ensembl.org/id/ENST00000507668
Ensembl	ENST00000509193	http://www.ensembl.org/id/ENST00000509193
Ensembl	ENST00000512972	http://www.ensembl.org/id/ENST00000512972
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0043209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043209
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0015194	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015194
GO_process	GO:0006658	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006658
GO_process	GO:0006665	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006665
GO_process	GO:0008654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008654
GO_process	GO:0009597	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009597
GO_process	GO:0042552	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042552
GO_process	GO:0045087	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045087
GO_process	GO:0051607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051607
GO_process	GO:1904219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1904219
GO_process	GO:1904222	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1904222
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
GeneCards	SERINC5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SERINC5
GeneID	256987	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=256987
GeneTree	ENSGT00550000074522	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074522
HGNC	HGNC:18825	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18825
HOGENOM	HOG000165463	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000165463&db=HOGENOM6
HOVERGEN	HBG025699	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG025699&db=HOVERGEN
HPA	HPA037898	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA037898
HPA	HPA037899	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA037899
InParanoid	Q86VE9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q86VE9
IntAct	Q86VE9	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q86VE9*
InterPro	IPR005016	http://www.ebi.ac.uk/interpro/entry/IPR005016
InterPro	IPR029555	http://www.ebi.ac.uk/interpro/entry/IPR029555
Jabion	256987	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=256987
KEGG_Gene	hsa:256987	http://www.genome.jp/dbget-bin/www_bget?hsa:256987
MIM	614551	http://www.ncbi.nlm.nih.gov/omim/614551
OMA	CCPTREF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CCPTREF
OrthoDB	EOG091G06BW	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G06BW
PANTHER	PTHR10383	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10383
PANTHER	PTHR10383:SF16	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10383:SF16
PSORT	swissprot:SERC5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SERC5_HUMAN
PSORT-B	swissprot:SERC5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SERC5_HUMAN
PSORT2	swissprot:SERC5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SERC5_HUMAN
Pfam	PF03348	http://pfam.xfam.org/family/PF03348
PharmGKB	PA38698	http://www.pharmgkb.org/do/serve?objId=PA38698&objCls=Gene
Phobius	swissprot:SERC5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SERC5_HUMAN
PhylomeDB	Q86VE9	http://phylomedb.org/?seqid=Q86VE9
ProteinModelPortal	Q86VE9	http://www.proteinmodelportal.org/query/uniprot/Q86VE9
PubMed	12688535	http://www.ncbi.nlm.nih.gov/pubmed/12688535
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	26416733	http://www.ncbi.nlm.nih.gov/pubmed/26416733
PubMed	26416734	http://www.ncbi.nlm.nih.gov/pubmed/26416734
Reactome	R-HSA-977347	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-977347
RefSeq	NP_001167542	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001167542
RefSeq	NP_001167543	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001167543
RefSeq	NP_840060	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_840060
STRING	9606.ENSP00000420863	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000420863&targetmode=cogs
UCSC	uc011ctj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc011ctj&org=rat
UniGene	Hs.288232	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.288232
UniProtKB	SERC5_HUMAN	http://www.uniprot.org/uniprot/SERC5_HUMAN
UniProtKB-AC	Q86VE9	http://www.uniprot.org/uniprot/Q86VE9
charge	swissprot:SERC5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SERC5_HUMAN
eggNOG	ENOG410XP7K	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XP7K
eggNOG	KOG2592	http://eggnogapi.embl.de/nog_data/html/tree/KOG2592
epestfind	swissprot:SERC5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SERC5_HUMAN
garnier	swissprot:SERC5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SERC5_HUMAN
helixturnhelix	swissprot:SERC5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SERC5_HUMAN
hmoment	swissprot:SERC5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SERC5_HUMAN
iep	swissprot:SERC5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SERC5_HUMAN
inforesidue	swissprot:SERC5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SERC5_HUMAN
neXtProt	NX_Q86VE9	http://www.nextprot.org/db/entry/NX_Q86VE9
octanol	swissprot:SERC5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SERC5_HUMAN
pepcoil	swissprot:SERC5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SERC5_HUMAN
pepdigest	swissprot:SERC5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SERC5_HUMAN
pepinfo	swissprot:SERC5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SERC5_HUMAN
pepnet	swissprot:SERC5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SERC5_HUMAN
pepstats	swissprot:SERC5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SERC5_HUMAN
pepwheel	swissprot:SERC5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SERC5_HUMAN
pepwindow	swissprot:SERC5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SERC5_HUMAN
sigcleave	swissprot:SERC5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SERC5_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TRPM4_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=TRPM4b; IsoId=Q8TD43-1; Sequence=Displayed; Name=2; Synonyms=TRPM4a; IsoId=Q8TD43-2; Sequence=VSP_021442; Name=3; Synonyms=TRPM4c; IsoId=Q8TD43-3; Sequence=VSP_021443; 
# AltName	TRPM4_HUMAN	Calcium-activated non-selective cation channel 1
# AltName	TRPM4_HUMAN	Long transient receptor potential channel 4
# AltName	TRPM4_HUMAN	Melastatin-4
# BioGrid	120154	8
# CCDS	CCDS33073	-. [Q8TD43-1]
# CCDS	CCDS56098	-. [Q8TD43-3]
# DISEASE	TRPM4_HUMAN	Progressive familial heart block 1B (PFHB1B) [MIM 604559]  A cardiac bundle branch disorder characterized by progressive alteration of cardiac conduction through the His- Purkinje system, with a pattern of a right bundle-branch block and/or left anterior hemiblock occurring individually or together. It leads to complete atrio-ventricular block causing syncope and sudden death. {ECO 0000269|PubMed 19726882, ECO 0000269|PubMed 20562447, ECO 0000269|PubMed 21887725}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# ENZYME REGULATION	TRPM4_HUMAN	Gating is voltage-dependent and repressed by decavanadate. Calmodulin-binding confers the Ca(2+) sensitivity. ATP is able to restore Ca(2+) sensitivity after desensitization. Phosphatidylinositol 4,5-bisphosphate (PIP2)-binding strongly enhances activity, by increasing the channel's Ca(2+) sensitivity and shifting its voltage dependence of activation towards negative potentials. Activity is also enhanced by 3,5- bis(trifluoromethyl)pyrazole derivative (BTP2). {ECO 0000269|PubMed 14758478, ECO 0000269|PubMed 15331675, ECO 0000269|PubMed 16186107, ECO 0000269|PubMed 16407466, ECO 0000269|PubMed 16424899}. 
# Ensembl	ENST00000252826	ENSP00000252826; ENSG00000130529. [Q8TD43-1]
# Ensembl	ENST00000427978	ENSP00000407492; ENSG00000130529. [Q8TD43-3]
# ExpressionAtlas	Q8TD43	baseline and differential
# FUNCTION	TRPM4_HUMAN	Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. {ECO 0000269|PubMed 12015988, ECO 0000269|PubMed 12799367, ECO 0000269|PubMed 15121803, ECO 0000269|PubMed 15472118, ECO 0000269|PubMed 15550671, ECO 0000269|PubMed 16806463, ECO 0000269|PubMed 20625999, ECO 0000269|PubMed 20656926}. 
# GO_component	GO:0005654	nucleoplasm; IDA:HPA.
# GO_component	GO:0005783	endoplasmic reticulum; IDA:UniProtKB.
# GO_component	GO:0005794	Golgi apparatus; IDA:UniProtKB.
# GO_component	GO:0005829	cytosol; ISS:BHF-UCL.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0043025	neuronal cell body; ISS:BHF-UCL.
# GO_function	GO:0005227	calcium activated cation channel activity; ISS:UniProtKB.
# GO_function	GO:0005262	calcium channel activity; IEA:Ensembl.
# GO_function	GO:0005272	sodium channel activity; TAS:Reactome.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_process	GO:0002250	adaptive immune response; IEA:UniProtKB-KW.
# GO_process	GO:0002407	dendritic cell chemotaxis; ISS:UniProtKB.
# GO_process	GO:0002724	regulation of T cell cytokine production; IDA:UniProtKB.
# GO_process	GO:0007204	positive regulation of cytosolic calcium ion concentration; ISS:BHF-UCL.
# GO_process	GO:0008284	positive regulation of cell proliferation; IDA:UniProtKB.
# GO_process	GO:0010460	positive regulation of heart rate; ISS:BHF-UCL.
# GO_process	GO:0016925	protein sumoylation; IDA:UniProtKB.
# GO_process	GO:0030502	negative regulation of bone mineralization; ISS:BHF-UCL.
# GO_process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus; ISS:BHF-UCL.
# GO_process	GO:0042310	vasoconstriction; IEA:InterPro.
# GO_process	GO:0045600	positive regulation of fat cell differentiation; ISS:BHF-UCL.
# GO_process	GO:0045668	negative regulation of osteoblast differentiation; ISS:BHF-UCL.
# GO_process	GO:0045907	positive regulation of vasoconstriction; ISS:BHF-UCL.
# GO_process	GO:0061337	cardiac conduction; IEA:InterPro.
# GO_process	GO:0070588	calcium ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0090263	positive regulation of canonical Wnt signaling pathway; IDA:UniProtKB.
# GO_process	GO:1903949	positive regulation of atrial cardiac muscle cell action potential; ISS:BHF-UCL.
# GO_process	GO:1904179	positive regulation of adipose tissue development; ISS:BHF-UCL.
# GO_process	GO:1904199	positive regulation of regulation of vascular smooth muscle cell membrane depolarization; ISS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0003013	circulatory system process
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048870	cell motility
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q8TD43	HS
# HGNC	HGNC:17993	TRPM4
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR029581	TRPM4
# KEGG_Brite	ko04040	Ion channels
# KEGG_Disease	H01263	[Cardiovascular disease] Lenegre-Lev disease
# MIM	604559	phenotype
# MIM	606936	gene
# Organism	TRPM4_HUMAN	Homo sapiens (Human)
# Orphanet	130	Brugada syndrome
# Orphanet	871	Familial progressive cardiac conduction defect
# PANTHER	PTHR13800:SF6	PTHR13800:SF6
# PTM	TRPM4_HUMAN	Phosphorylation by PKC leads to increase the sensitivity to Ca(2+). {ECO 0000269|PubMed 15590641}. 
# PTM	TRPM4_HUMAN	Sumoylated. Desumoylated by SENP1. {ECO 0000269|PubMed 19726882}. 
# Pfam	PF00520	Ion_trans
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-3295583	TRP channels
# RecName	TRPM4_HUMAN	Transient receptor potential cation channel subfamily M member 4
# RefSeq	NP_001182156	NM_001195227.1. [Q8TD43-3]
# RefSeq	NP_001308212	NM_001321283.1. [Q8TD43-2]
# RefSeq	NP_060106	NM_017636.3. [Q8TD43-1]
# SEQUENCE CAUTION	Sequence=BAA90907.1; Type=Erroneous termination; Positions=1191; Note=Translated as Glu.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM4 sub-subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	TRPM4_HUMAN	Isoform 1  Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum. Golgi apparatus. 
# SUBCELLULAR LOCATION	TRPM4_HUMAN	Isoform 2  Endoplasmic reticulum. Golgi apparatus. 
# SUBUNIT	Homomultimer. {ECO:0000269|PubMed	12015988}. 
# TCDB	1.A.4.5	the transient receptor potential ca(2+) channel (trp-cc) family
# TISSUE SPECIFICITY	TRPM4_HUMAN	Widely expressed with a high expression in intestine and prostate. In brain, it is both expressed in whole cerebral arteries and isolated vascular smooth muscle cells. Prominently expressed in Purkinje fibers. Expressed at higher levels in T-helper 2 (Th2) cells as compared to T-helper 1 (Th1) cells. {ECO 0000269|PubMed 11535825, ECO 0000269|PubMed 12015988, ECO 0000269|PubMed 12799367, ECO 0000269|PubMed 15472118, ECO 0000269|PubMed 16777713, ECO 0000269|PubMed 19726882, ECO 0000269|PubMed 20656926}. 
# UCSC	uc002pmw	human. [Q8TD43-1]
# eggNOG	ENOG410XR5B	LUCA
# eggNOG	KOG3614	Eukaryota
BLAST	swissprot:TRPM4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TRPM4_HUMAN
BioCyc	ZFISH:ENSG00000130529-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000130529-MONOMER
COXPRESdb	54795	http://coxpresdb.jp/data/gene/54795.shtml
CleanEx	HS_TRPM4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TRPM4
DOI	10.1002/humu.21599	http://dx.doi.org/10.1002/humu.21599
DOI	10.1002/jcp.22310	http://dx.doi.org/10.1002/jcp.22310
DOI	10.1007/s00424-003-1221-x	http://dx.doi.org/10.1007/s00424-003-1221-x
DOI	10.1016/S0092-8674(02)00719-5	http://dx.doi.org/10.1016/S0092-8674(02)00719-5
DOI	10.1016/S0960-9822(03)00431-7	http://dx.doi.org/10.1016/S0960-9822(03)00431-7
DOI	10.1016/j.bbrc.2009.11.142	http://dx.doi.org/10.1016/j.bbrc.2009.11.142
DOI	10.1016/j.ceca.2006.04.032	http://dx.doi.org/10.1016/j.ceca.2006.04.032
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.emboj.7600963	http://dx.doi.org/10.1038/sj.emboj.7600963
DOI	10.1073/pnas.191360198	http://dx.doi.org/10.1073/pnas.191360198
DOI	10.1074/jbc.M305127200	http://dx.doi.org/10.1074/jbc.M305127200
DOI	10.1074/jbc.M411089200	http://dx.doi.org/10.1074/jbc.M411089200
DOI	10.1074/jbc.M501686200	http://dx.doi.org/10.1074/jbc.M501686200
DOI	10.1074/jbc.M506965200	http://dx.doi.org/10.1074/jbc.M506965200
DOI	10.1080/10799890600637506	http://dx.doi.org/10.1080/10799890600637506
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1113/jphysiol.2004.063974	http://dx.doi.org/10.1113/jphysiol.2004.063974
DOI	10.1113/jphysiol.2004.070839	http://dx.doi.org/10.1113/jphysiol.2004.070839
DOI	10.1124/mol.105.021154	http://dx.doi.org/10.1124/mol.105.021154
DOI	10.1126/science.1098845	http://dx.doi.org/10.1126/science.1098845
DOI	10.1161/01.RES.0000147311.54833.03	http://dx.doi.org/10.1161/01.RES.0000147311.54833.03
DOI	10.1161/CIRCGENETICS.109.930867	http://dx.doi.org/10.1161/CIRCGENETICS.109.930867
DOI	10.1172/JCI38292	http://dx.doi.org/10.1172/JCI38292
DOI	10.4049/jimmunol.1000880	http://dx.doi.org/10.4049/jimmunol.1000880
EMBL	AF497623	http://www.ebi.ac.uk/ena/data/view/AF497623
EMBL	AJ575813	http://www.ebi.ac.uk/ena/data/view/AJ575813
EMBL	AK000048	http://www.ebi.ac.uk/ena/data/view/AK000048
EMBL	AK292862	http://www.ebi.ac.uk/ena/data/view/AK292862
EMBL	AY046396	http://www.ebi.ac.uk/ena/data/view/AY046396
EMBL	AY297044	http://www.ebi.ac.uk/ena/data/view/AY297044
EMBL	AY297045	http://www.ebi.ac.uk/ena/data/view/AY297045
EMBL	AY297046	http://www.ebi.ac.uk/ena/data/view/AY297046
EMBL	BC132727	http://www.ebi.ac.uk/ena/data/view/BC132727
Ensembl	ENST00000252826	http://www.ensembl.org/id/ENST00000252826
Ensembl	ENST00000427978	http://www.ensembl.org/id/ENST00000427978
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_function	GO:0005227	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005227
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0005272	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005272
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_process	GO:0002250	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002250
GO_process	GO:0002407	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002407
GO_process	GO:0002724	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002724
GO_process	GO:0007204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007204
GO_process	GO:0008284	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008284
GO_process	GO:0010460	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010460
GO_process	GO:0016925	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016925
GO_process	GO:0030502	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030502
GO_process	GO:0035774	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035774
GO_process	GO:0042310	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042310
GO_process	GO:0045600	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045600
GO_process	GO:0045668	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045668
GO_process	GO:0045907	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045907
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:0090263	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090263
GO_process	GO:1903949	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903949
GO_process	GO:1904179	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1904179
GO_process	GO:1904199	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1904199
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0003013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003013
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	TRPM4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TRPM4
GeneID	54795	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54795
GeneTree	ENSGT00760000119127	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119127
HGNC	HGNC:17993	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17993
HOGENOM	HOG000236350	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236350&db=HOGENOM6
HOVERGEN	HBG108337	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108337&db=HOVERGEN
HPA	HPA041169	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA041169
InParanoid	Q8TD43	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8TD43
IntAct	Q8TD43	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8TD43*
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR029581	http://www.ebi.ac.uk/interpro/entry/IPR029581
Jabion	54795	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=54795
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H01263	http://www.genome.jp/dbget-bin/www_bget?H01263
KEGG_Gene	hsa:54795	http://www.genome.jp/dbget-bin/www_bget?hsa:54795
KEGG_Orthology	KO:K04979	http://www.genome.jp/dbget-bin/www_bget?KO:K04979
MIM	604559	http://www.ncbi.nlm.nih.gov/omim/604559
MIM	606936	http://www.ncbi.nlm.nih.gov/omim/606936
OMA	FLRLSCD	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FLRLSCD
Orphanet	130	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=130
Orphanet	871	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=871
OrthoDB	EOG091G017C	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G017C
PANTHER	PTHR13800:SF6	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13800:SF6
PSORT	swissprot:TRPM4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TRPM4_HUMAN
PSORT-B	swissprot:TRPM4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TRPM4_HUMAN
PSORT2	swissprot:TRPM4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TRPM4_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
PharmGKB	PA38272	http://www.pharmgkb.org/do/serve?objId=PA38272&objCls=Gene
Phobius	swissprot:TRPM4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TRPM4_HUMAN
PhylomeDB	Q8TD43	http://phylomedb.org/?seqid=Q8TD43
ProteinModelPortal	Q8TD43	http://www.proteinmodelportal.org/query/uniprot/Q8TD43
PubMed	11535825	http://www.ncbi.nlm.nih.gov/pubmed/11535825
PubMed	12015988	http://www.ncbi.nlm.nih.gov/pubmed/12015988
PubMed	12799367	http://www.ncbi.nlm.nih.gov/pubmed/12799367
PubMed	12842017	http://www.ncbi.nlm.nih.gov/pubmed/12842017
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	14758478	http://www.ncbi.nlm.nih.gov/pubmed/14758478
PubMed	15121803	http://www.ncbi.nlm.nih.gov/pubmed/15121803
PubMed	15331675	http://www.ncbi.nlm.nih.gov/pubmed/15331675
PubMed	15472118	http://www.ncbi.nlm.nih.gov/pubmed/15472118
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15550671	http://www.ncbi.nlm.nih.gov/pubmed/15550671
PubMed	15590641	http://www.ncbi.nlm.nih.gov/pubmed/15590641
PubMed	15845551	http://www.ncbi.nlm.nih.gov/pubmed/15845551
PubMed	16186107	http://www.ncbi.nlm.nih.gov/pubmed/16186107
PubMed	16407466	http://www.ncbi.nlm.nih.gov/pubmed/16407466
PubMed	16424899	http://www.ncbi.nlm.nih.gov/pubmed/16424899
PubMed	16777713	http://www.ncbi.nlm.nih.gov/pubmed/16777713
PubMed	16806463	http://www.ncbi.nlm.nih.gov/pubmed/16806463
PubMed	19726882	http://www.ncbi.nlm.nih.gov/pubmed/19726882
PubMed	19945433	http://www.ncbi.nlm.nih.gov/pubmed/19945433
PubMed	20562447	http://www.ncbi.nlm.nih.gov/pubmed/20562447
PubMed	20625999	http://www.ncbi.nlm.nih.gov/pubmed/20625999
PubMed	20656926	http://www.ncbi.nlm.nih.gov/pubmed/20656926
PubMed	21887725	http://www.ncbi.nlm.nih.gov/pubmed/21887725
Reactome	R-HSA-3295583	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3295583
RefSeq	NP_001182156	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001182156
RefSeq	NP_001308212	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001308212
RefSeq	NP_060106	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060106
STRING	9606.ENSP00000252826	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000252826&targetmode=cogs
TCDB	1.A.4.5	http://www.tcdb.org/search/result.php?tc=1.A.4.5
UCSC	uc002pmw	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002pmw&org=rat
UniGene	Hs.467101	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.467101
UniProtKB	TRPM4_HUMAN	http://www.uniprot.org/uniprot/TRPM4_HUMAN
UniProtKB-AC	Q8TD43	http://www.uniprot.org/uniprot/Q8TD43
charge	swissprot:TRPM4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TRPM4_HUMAN
eggNOG	ENOG410XR5B	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XR5B
eggNOG	KOG3614	http://eggnogapi.embl.de/nog_data/html/tree/KOG3614
epestfind	swissprot:TRPM4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TRPM4_HUMAN
garnier	swissprot:TRPM4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TRPM4_HUMAN
helixturnhelix	swissprot:TRPM4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRPM4_HUMAN
hmoment	swissprot:TRPM4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TRPM4_HUMAN
iep	swissprot:TRPM4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TRPM4_HUMAN
inforesidue	swissprot:TRPM4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TRPM4_HUMAN
neXtProt	NX_Q8TD43	http://www.nextprot.org/db/entry/NX_Q8TD43
octanol	swissprot:TRPM4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TRPM4_HUMAN
pepcoil	swissprot:TRPM4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TRPM4_HUMAN
pepdigest	swissprot:TRPM4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TRPM4_HUMAN
pepinfo	swissprot:TRPM4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TRPM4_HUMAN
pepnet	swissprot:TRPM4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TRPM4_HUMAN
pepstats	swissprot:TRPM4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TRPM4_HUMAN
pepwheel	swissprot:TRPM4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TRPM4_HUMAN
pepwindow	swissprot:TRPM4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TRPM4_HUMAN
sigcleave	swissprot:TRPM4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TRPM4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S26A5_HUMAN	Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=SLC26A5a; IsoId=P58743-1; Sequence=Displayed; Name=2; Synonyms=SLC26A5b; IsoId=P58743-2; Sequence=VSP_010194, VSP_010195; Name=3; Synonyms=SLC26A5c; IsoId=P58743-3; Sequence=VSP_010192, VSP_010193; Name=4; Synonyms=SLC26A5d; IsoId=P58743-4; Sequence=VSP_010190, VSP_010191; Name=5; IsoId=P58743-5; Sequence=VSP_043153; Note=No experimental confirmation available.; Name=6; IsoId=P58743-6; Sequence=VSP_043153, VSP_047640; 
# AltName	S26A5_HUMAN	Solute carrier family 26 member 5
# CCDS	CCDS43629	-. [P58743-3]
# CCDS	CCDS43630	-. [P58743-2]
# CCDS	CCDS55150	-. [P58743-5]
# CCDS	CCDS5732	-. [P58743-4]
# CCDS	CCDS5733	-. [P58743-1]
# DISEASE	S26A5_HUMAN	Deafness, autosomal recessive, 61 (DFNB61) [MIM 613865]  A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO 0000269|PubMed 12719379}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000306312	ENSP00000304783; ENSG00000170615. [P58743-1]
# Ensembl	ENST00000339444	ENSP00000342396; ENSG00000170615. [P58743-2]
# Ensembl	ENST00000356767	ENSP00000349210; ENSG00000170615. [P58743-4]
# Ensembl	ENST00000393723	ENSP00000377324; ENSG00000170615. [P58743-6]
# Ensembl	ENST00000393730	ENSP00000377331; ENSG00000170615. [P58743-5]
# Ensembl	ENST00000393735	ENSP00000377336; ENSG00000170615. [P58743-3]
# Ensembl	ENST00000432958	ENSP00000389733; ENSG00000170615. [P58743-5]
# ExpressionAtlas	P58743	baseline and differential
# FUNCTION	S26A5_HUMAN	Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage- to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site (By similarity). {ECO 0000250}. 
# GO_component	GO:0005737	cytoplasm; IEA:Ensembl.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:Ensembl.
# GO_component	GO:0016328	lateral plasma membrane; IEA:Ensembl.
# GO_function	GO:0005254	chloride channel activity; IBA:GO_Central.
# GO_function	GO:0008271	secondary active sulfate transmembrane transporter activity; IEA:InterPro.
# GO_function	GO:0015106	bicarbonate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015116	sulfate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0019531	oxalate transmembrane transporter activity; IBA:GO_Central.
# GO_function	S26A5_HUMAN	GO 0015301 anion anion antiporter activity; IBA GO_Central.
# GO_process	GO:0002931	response to ischemia; IEA:Ensembl.
# GO_process	GO:0007605	sensory perception of sound; IMP:UniProtKB.
# GO_process	GO:0008360	regulation of cell shape; IEA:UniProtKB-KW.
# GO_process	GO:0009751	response to salicylic acid; IEA:Ensembl.
# GO_process	GO:0010996	response to auditory stimulus; IEA:Ensembl.
# GO_process	GO:0015701	bicarbonate transport; IBA:GO_Central.
# GO_process	GO:0015755	fructose transport; IEA:Ensembl.
# GO_process	GO:0034766	negative regulation of ion transmembrane transport; IEA:Ensembl.
# GO_process	GO:0035864	response to potassium ion; IEA:Ensembl.
# GO_process	GO:0042391	regulation of membrane potential; IBA:GO_Central.
# GO_process	GO:0042493	response to drug; IEA:Ensembl.
# GO_process	GO:0045793	positive regulation of cell size; IEA:Ensembl.
# GO_process	GO:0051262	protein tetramerization; IEA:Ensembl.
# GO_process	GO:0051453	regulation of intracellular pH; IBA:GO_Central.
# GO_process	GO:0090102	cochlea development; IEA:Ensembl.
# GO_process	GO:0097066	response to thyroid hormone; IEA:Ensembl.
# GO_process	GO:1902074	response to salt; IEA:Ensembl.
# GO_process	GO:1902476	chloride transmembrane transport; IBA:GO_Central.
# GO_process	GO:2000147	positive regulation of cell motility; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.30.750.24	-; 2.
# HGNC	HGNC:9359	SLC26A5
# InterPro	IPR001902	SLC26A/SulP_fam
# InterPro	IPR002645	STAS_dom
# InterPro	IPR011547	SLC26A/SulP_dom
# InterPro	IPR018045	S04_transporter_CS
# InterPro	IPR030282	Prestin
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H00605	[Nervous system disease; Nervous system disease] Deafness, autosomal recessive
# MIM	604943	gene
# MIM	613865	phenotype
# Organism	S26A5_HUMAN	Homo sapiens (Human)
# Orphanet	90636	Autosomal recessive non-syndromic sensorineural deafness type DFNB
# PANTHER	PTHR11814	PTHR11814; 2
# PANTHER	PTHR11814:SF32	PTHR11814:SF32; 2
# PROSITE	PS01130	SLC26A
# PROSITE	PS50801	STAS
# Pfam	PF00916	Sulfate_transp
# Pfam	PF01740	STAS
# Proteomes	UP000005640	Chromosome 7
# RecName	S26A5_HUMAN	Prestin
# RefSeq	NP_001161434	NM_001167962.1. [P58743-5]
# RefSeq	NP_001308716	NM_001321787.1
# RefSeq	NP_945350	NM_198999.2. [P58743-1]
# RefSeq	NP_996766	NM_206883.2. [P58743-2]
# RefSeq	NP_996767	NM_206884.2. [P58743-3]
# RefSeq	NP_996768	NM_206885.2. [P58743-4]
# RefSeq	XP_011514472	XM_011516170.2. [P58743-1]
# SIMILARITY	Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. {ECO	0000305}. 
# SIMILARITY	Contains 1 STAS domain. {ECO:0000255|PROSITE- ProRule	PRU00198}. 
# SUBCELLULAR LOCATION	S26A5_HUMAN	Cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Note=Lateral wall of outer hair cells. {ECO 0000250}. 
# SUPFAM	SSF52091	SSF52091; 2
# TCDB	2.A.53.2.19	the sulfate permease (sulp) family
# TIGRFAMs	TIGR00815	sulP
# UCSC	uc003vbt	human. [P58743-1]
# WEB RESOURCE	S26A5_HUMAN	Name=Protein Spotlight; Note=Pump up the volume - Issue 22 of May 2002; URL="http //web.expasy.org/spotlight/back_issues/022";
# eggNOG	COG0659	LUCA
# eggNOG	KOG0236	Eukaryota
BLAST	swissprot:S26A5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S26A5_HUMAN
BioCyc	ZFISH:ENSG00000170615-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000170615-MONOMER
COXPRESdb	375611	http://coxpresdb.jp/data/gene/375611.shtml
CleanEx	HS_SLC26A5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC26A5
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1093/hmg/ddg127	http://dx.doi.org/10.1093/hmg/ddg127
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC004668	http://www.ebi.ac.uk/ena/data/view/AC004668
EMBL	AC005064	http://www.ebi.ac.uk/ena/data/view/AC005064
EMBL	AC093701	http://www.ebi.ac.uk/ena/data/view/AC093701
EMBL	AF523354	http://www.ebi.ac.uk/ena/data/view/AF523354
EMBL	AY256823	http://www.ebi.ac.uk/ena/data/view/AY256823
EMBL	AY256824	http://www.ebi.ac.uk/ena/data/view/AY256824
EMBL	AY256825	http://www.ebi.ac.uk/ena/data/view/AY256825
EMBL	AY289134	http://www.ebi.ac.uk/ena/data/view/AY289134
EMBL	BC100833	http://www.ebi.ac.uk/ena/data/view/BC100833
Ensembl	ENST00000306312	http://www.ensembl.org/id/ENST00000306312
Ensembl	ENST00000339444	http://www.ensembl.org/id/ENST00000339444
Ensembl	ENST00000356767	http://www.ensembl.org/id/ENST00000356767
Ensembl	ENST00000393723	http://www.ensembl.org/id/ENST00000393723
Ensembl	ENST00000393730	http://www.ensembl.org/id/ENST00000393730
Ensembl	ENST00000393735	http://www.ensembl.org/id/ENST00000393735
Ensembl	ENST00000432958	http://www.ensembl.org/id/ENST00000432958
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0016328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016328
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0008271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008271
GO_function	GO:0015106	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015106
GO_function	GO:0015116	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015116
GO_function	GO:0015301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015301
GO_function	GO:0019531	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019531
GO_process	GO:0002931	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002931
GO_process	GO:0007605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007605
GO_process	GO:0008360	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360
GO_process	GO:0009751	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009751
GO_process	GO:0010996	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010996
GO_process	GO:0015701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015701
GO_process	GO:0015755	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015755
GO_process	GO:0034766	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034766
GO_process	GO:0035864	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035864
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0045793	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045793
GO_process	GO:0051262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051262
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GO_process	GO:0090102	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090102
GO_process	GO:0097066	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097066
GO_process	GO:1902074	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902074
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GO_process	GO:2000147	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000147
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.30.750.24	http://www.cathdb.info/version/latest/superfamily/3.30.750.24
GeneCards	SLC26A5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC26A5
GeneID	375611	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=375611
GeneTree	ENSGT00760000119026	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119026
HGNC	HGNC:9359	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:9359
HOGENOM	HOG000006546	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006546&db=HOGENOM6
HOVERGEN	HBG000639	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000639&db=HOVERGEN
InParanoid	P58743	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P58743
InterPro	IPR001902	http://www.ebi.ac.uk/interpro/entry/IPR001902
InterPro	IPR002645	http://www.ebi.ac.uk/interpro/entry/IPR002645
InterPro	IPR011547	http://www.ebi.ac.uk/interpro/entry/IPR011547
InterPro	IPR018045	http://www.ebi.ac.uk/interpro/entry/IPR018045
InterPro	IPR030282	http://www.ebi.ac.uk/interpro/entry/IPR030282
Jabion	375611	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=375611
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00605	http://www.genome.jp/dbget-bin/www_bget?H00605
KEGG_Gene	hsa:375611	http://www.genome.jp/dbget-bin/www_bget?hsa:375611
KEGG_Orthology	KO:K14703	http://www.genome.jp/dbget-bin/www_bget?KO:K14703
MIM	604943	http://www.ncbi.nlm.nih.gov/omim/604943
MIM	613865	http://www.ncbi.nlm.nih.gov/omim/613865
Orphanet	90636	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=90636
PANTHER	PTHR11814	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11814
PANTHER	PTHR11814:SF32	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11814:SF32
PROSITE	PS01130	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01130
PROSITE	PS50801	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50801
PSORT	swissprot:S26A5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S26A5_HUMAN
PSORT-B	swissprot:S26A5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S26A5_HUMAN
PSORT2	swissprot:S26A5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S26A5_HUMAN
Pfam	PF00916	http://pfam.xfam.org/family/PF00916
Pfam	PF01740	http://pfam.xfam.org/family/PF01740
PharmGKB	PA33731	http://www.pharmgkb.org/do/serve?objId=PA33731&objCls=Gene
Phobius	swissprot:S26A5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S26A5_HUMAN
PhylomeDB	P58743	http://phylomedb.org/?seqid=P58743
ProteinModelPortal	P58743	http://www.proteinmodelportal.org/query/uniprot/P58743
PubMed	12719379	http://www.ncbi.nlm.nih.gov/pubmed/12719379
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
RefSeq	NP_001161434	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001161434
RefSeq	NP_001308716	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001308716
RefSeq	NP_945350	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_945350
RefSeq	NP_996766	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_996766
RefSeq	NP_996767	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_996767
RefSeq	NP_996768	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_996768
RefSeq	XP_011514472	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011514472
SMR	P58743	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P58743
STRING	9606.ENSP00000304783	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000304783&targetmode=cogs
SUPFAM	SSF52091	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52091
TCDB	2.A.53.2.19	http://www.tcdb.org/search/result.php?tc=2.A.53.2.19
TIGRFAMs	TIGR00815	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00815
UCSC	uc003vbt	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003vbt&org=rat
UniGene	Hs.585146	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.585146
UniProtKB	S26A5_HUMAN	http://www.uniprot.org/uniprot/S26A5_HUMAN
UniProtKB-AC	P58743	http://www.uniprot.org/uniprot/P58743
charge	swissprot:S26A5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S26A5_HUMAN
eggNOG	COG0659	http://eggnogapi.embl.de/nog_data/html/tree/COG0659
eggNOG	KOG0236	http://eggnogapi.embl.de/nog_data/html/tree/KOG0236
epestfind	swissprot:S26A5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S26A5_HUMAN
garnier	swissprot:S26A5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S26A5_HUMAN
helixturnhelix	swissprot:S26A5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S26A5_HUMAN
hmoment	swissprot:S26A5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S26A5_HUMAN
iep	swissprot:S26A5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S26A5_HUMAN
inforesidue	swissprot:S26A5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S26A5_HUMAN
neXtProt	NX_P58743	http://www.nextprot.org/db/entry/NX_P58743
octanol	swissprot:S26A5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S26A5_HUMAN
pepcoil	swissprot:S26A5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S26A5_HUMAN
pepdigest	swissprot:S26A5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S26A5_HUMAN
pepinfo	swissprot:S26A5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S26A5_HUMAN
pepnet	swissprot:S26A5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S26A5_HUMAN
pepstats	swissprot:S26A5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S26A5_HUMAN
pepwheel	swissprot:S26A5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S26A5_HUMAN
pepwindow	swissprot:S26A5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S26A5_HUMAN
sigcleave	swissprot:S26A5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S26A5_HUMAN
## Database	ID	URL or Descriptions
# AltName	SPN1_HUMAN	RNA U transporter 1
# BioGrid	115384	30
# ChiTaRS	SNUPN	human
# Ensembl	ENST00000308588	ENSP00000309831; ENSG00000169371
# Ensembl	ENST00000564644	ENSP00000454852; ENSG00000169371
# Ensembl	ENST00000564675	ENSP00000458053; ENSG00000169371
# Ensembl	ENST00000567134	ENSP00000456224; ENSG00000169371
# ExpressionAtlas	O95149	baseline and differential
# FUNCTION	SPN1_HUMAN	Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. {ECO 0000269|PubMed 10209022, ECO 0000269|PubMed 15920472, ECO 0000269|PubMed 16030253, ECO 0000269|PubMed 9670026}. 
# GO_component	GO:0005643	nuclear pore; TAS:ProtInc.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0000339	RNA cap binding; TAS:ProtInc.
# GO_function	GO:0008565	protein transporter activity; IEA:InterPro.
# GO_process	GO:0000387	spliceosomal snRNP assembly; TAS:Reactome.
# GO_process	GO:0006606	protein import into nucleus; IEA:InterPro.
# GO_process	GO:0051170	nuclear import; TAS:Reactome.
# GO_process	GO:0061015	snRNA import into nucleus; IEA:InterPro.
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003723	RNA binding
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# GOslim_process	GO:0022618	ribonucleoprotein complex assembly
# Genevisible	O95149	HS
# HGNC	HGNC:14245	SNUPN
# IntAct	O95149	17
# InterPro	IPR002652	Importin-a_IBB
# InterPro	IPR017336	Snurportin-1
# InterPro	IPR024721	Snurportin-1_N
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko03041	 Spliceosome
# KEGG_Pathway	ko03013	RNA transport
# MIM	607902	gene
# Organism	SPN1_HUMAN	Homo sapiens (Human)
# PDB	1XK5	X-ray; 2.40 A; A=97-300
# PDB	2P8Q	X-ray; 2.35 A; B=25-64
# PDB	2Q5D	X-ray; 3.20 A; C/D=25-64
# PDB	2QNA	X-ray; 2.84 A; B=1-66
# PDB	3GB8	X-ray; 2.90 A; B=1-328
# PDB	3GJX	X-ray; 2.50 A; B/E=1-360
# PDB	3LWW	X-ray; 3.15 A; B/D=25-64
# PDB	3NBY	X-ray; 3.42 A; B/E=15-360
# PDB	3NBZ	X-ray; 2.80 A; B/E=15-360
# PDB	3NC0	X-ray; 2.90 A; B/E=15-360
# PDB	5DIS	X-ray; 2.85 A; C=1-287
# PIRSF	PIRSF037955	Snurportin-1
# PROSITE	PS51214	IBB
# Pfam	PF11538	Snurportin1
# Proteomes	UP000005640	Chromosome 15
# Reactome	R-HSA-191859	snRNP Assembly
# RecName	SPN1_HUMAN	Snurportin-1
# RefSeq	NP_001036046	NM_001042581.1
# RefSeq	NP_001036053	NM_001042588.1
# RefSeq	NP_005692	NM_005701.3
# SIMILARITY	Belongs to the snurportin family. {ECO	0000305}. 
# SIMILARITY	Contains 1 IBB domain. {ECO:0000255|PROSITE- ProRule	PRU00561}.
# SUBCELLULAR LOCATION	SPN1_HUMAN	Nucleus {ECO 0000269|PubMed 10209022, ECO 0000269|PubMed 15920472}. Cytoplasm {ECO 0000269|PubMed 12095920, ECO 0000269|PubMed 9670026, ECO 0000305|PubMed 10209022}. Note=Nucleoplasmic shuttling protein. Its nuclear import involves the nucleocytoplasmic transport receptor importin beta (PubMed 10209022, PubMed 12095920). It is re-exported to the cytoplasm by the XPO1- dependent nuclear export receptor pathway (PubMed 10209022). {ECO 0000269|PubMed 10209022, ECO 0000269|PubMed 12095920}. 
# SUBUNIT	SPN1_HUMAN	Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, Ran and XPO1. Interacts (via IBB domain) with KPNB1; the interaction is direct. Interacts with DDX20, IPO7, SMN1, SNRPB and XPO1. Interacts directly with XPO1. Its interaction with XPO1 and binding to m3G-cap U snRNPs appears to be mutually exclusive. {ECO 0000269|PubMed 10209022, ECO 0000269|PubMed 12095920, ECO 0000269|PubMed 15920472, ECO 0000269|PubMed 16030253, ECO 0000269|PubMed 18187419, ECO 0000269|PubMed 20476751, ECO 0000269|PubMed 9670026}. 
# UCSC	uc002ban	human
# eggNOG	ENOG410XQNJ	LUCA
# eggNOG	KOG3132	Eukaryota
BLAST	swissprot:SPN1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SPN1_HUMAN
BioCyc	ZFISH:ENSG00000169371-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000169371-MONOMER
COXPRESdb	10073	http://coxpresdb.jp/data/gene/10073.shtml
CleanEx	HS_SNUPN	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SNUPN
DIP	DIP-48513N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48513N
DOI	10.1021/bi100292y	http://dx.doi.org/10.1021/bi100292y
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.emboj.7600701	http://dx.doi.org/10.1038/sj.emboj.7600701
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/jbc.M709093200	http://dx.doi.org/10.1074/jbc.M709093200
DOI	10.1083/jcb.145.2.255	http://dx.doi.org/10.1083/jcb.145.2.255
DOI	10.1091/mbc.E05-04-0316	http://dx.doi.org/10.1091/mbc.E05-04-0316
DOI	10.1093/emboj/17.14.4114	http://dx.doi.org/10.1093/emboj/17.14.4114
DOI	10.1093/hmg/11.15.1785	http://dx.doi.org/10.1093/hmg/11.15.1785
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF039029	http://www.ebi.ac.uk/ena/data/view/AF039029
EMBL	AK289475	http://www.ebi.ac.uk/ena/data/view/AK289475
EMBL	BC004203	http://www.ebi.ac.uk/ena/data/view/BC004203
EMBL	CH471136	http://www.ebi.ac.uk/ena/data/view/CH471136
EMBL	CH471136	http://www.ebi.ac.uk/ena/data/view/CH471136
EMBL	CR456811	http://www.ebi.ac.uk/ena/data/view/CR456811
Ensembl	ENST00000308588	http://www.ensembl.org/id/ENST00000308588
Ensembl	ENST00000564644	http://www.ensembl.org/id/ENST00000564644
Ensembl	ENST00000564675	http://www.ensembl.org/id/ENST00000564675
Ensembl	ENST00000567134	http://www.ensembl.org/id/ENST00000567134
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005643	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005643
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0000339	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000339
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0000387	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000387
GO_process	GO:0006606	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006606
GO_process	GO:0051170	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051170
GO_process	GO:0061015	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061015
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003723	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
GOslim_process	GO:0022618	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022618
GeneCards	SNUPN	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SNUPN
GeneID	10073	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10073
GeneTree	ENSGT00510000047494	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00510000047494
HGNC	HGNC:14245	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14245
HOGENOM	HOG000012990	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000012990&db=HOGENOM6
HOVERGEN	HBG053257	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053257&db=HOVERGEN
HPA	CAB005004	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB005004
InParanoid	O95149	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O95149
IntAct	O95149	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O95149*
InterPro	IPR002652	http://www.ebi.ac.uk/interpro/entry/IPR002652
InterPro	IPR017336	http://www.ebi.ac.uk/interpro/entry/IPR017336
InterPro	IPR024721	http://www.ebi.ac.uk/interpro/entry/IPR024721
Jabion	10073	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10073
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko03041	http://www.genome.jp/dbget-bin/www_bget?ko03041
KEGG_Gene	hsa:10073	http://www.genome.jp/dbget-bin/www_bget?hsa:10073
KEGG_Orthology	KO:K13151	http://www.genome.jp/dbget-bin/www_bget?KO:K13151
KEGG_Pathway	ko03013	http://www.genome.jp/kegg-bin/show_pathway?ko03013
MIM	607902	http://www.ncbi.nlm.nih.gov/omim/607902
MINT	MINT-1378592	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1378592
OMA	YHRQTHY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YHRQTHY
OrthoDB	EOG091G0PL0	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0PL0
PDB	1XK5	http://www.ebi.ac.uk/pdbe-srv/view/entry/1XK5
PDB	2P8Q	http://www.ebi.ac.uk/pdbe-srv/view/entry/2P8Q
PDB	2Q5D	http://www.ebi.ac.uk/pdbe-srv/view/entry/2Q5D
PDB	2QNA	http://www.ebi.ac.uk/pdbe-srv/view/entry/2QNA
PDB	3GB8	http://www.ebi.ac.uk/pdbe-srv/view/entry/3GB8
PDB	3GJX	http://www.ebi.ac.uk/pdbe-srv/view/entry/3GJX
PDB	3LWW	http://www.ebi.ac.uk/pdbe-srv/view/entry/3LWW
PDB	3NBY	http://www.ebi.ac.uk/pdbe-srv/view/entry/3NBY
PDB	3NBZ	http://www.ebi.ac.uk/pdbe-srv/view/entry/3NBZ
PDB	3NC0	http://www.ebi.ac.uk/pdbe-srv/view/entry/3NC0
PDB	5DIS	http://www.ebi.ac.uk/pdbe-srv/view/entry/5DIS
PDBsum	1XK5	http://www.ebi.ac.uk/pdbsum/1XK5
PDBsum	2P8Q	http://www.ebi.ac.uk/pdbsum/2P8Q
PDBsum	2Q5D	http://www.ebi.ac.uk/pdbsum/2Q5D
PDBsum	2QNA	http://www.ebi.ac.uk/pdbsum/2QNA
PDBsum	3GB8	http://www.ebi.ac.uk/pdbsum/3GB8
PDBsum	3GJX	http://www.ebi.ac.uk/pdbsum/3GJX
PDBsum	3LWW	http://www.ebi.ac.uk/pdbsum/3LWW
PDBsum	3NBY	http://www.ebi.ac.uk/pdbsum/3NBY
PDBsum	3NBZ	http://www.ebi.ac.uk/pdbsum/3NBZ
PDBsum	3NC0	http://www.ebi.ac.uk/pdbsum/3NC0
PDBsum	5DIS	http://www.ebi.ac.uk/pdbsum/5DIS
PROSITE	PS51214	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51214
PSORT	swissprot:SPN1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SPN1_HUMAN
PSORT-B	swissprot:SPN1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SPN1_HUMAN
PSORT2	swissprot:SPN1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SPN1_HUMAN
Pfam	PF11538	http://pfam.xfam.org/family/PF11538
PharmGKB	PA34611	http://www.pharmgkb.org/do/serve?objId=PA34611&objCls=Gene
Phobius	swissprot:SPN1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SPN1_HUMAN
PhylomeDB	O95149	http://phylomedb.org/?seqid=O95149
ProteinModelPortal	O95149	http://www.proteinmodelportal.org/query/uniprot/O95149
PubMed	10209022	http://www.ncbi.nlm.nih.gov/pubmed/10209022
PubMed	12095920	http://www.ncbi.nlm.nih.gov/pubmed/12095920
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15920472	http://www.ncbi.nlm.nih.gov/pubmed/15920472
PubMed	16030253	http://www.ncbi.nlm.nih.gov/pubmed/16030253
PubMed	18187419	http://www.ncbi.nlm.nih.gov/pubmed/18187419
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	20476751	http://www.ncbi.nlm.nih.gov/pubmed/20476751
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	9670026	http://www.ncbi.nlm.nih.gov/pubmed/9670026
Reactome	R-HSA-191859	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-191859
RefSeq	NP_001036046	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001036046
RefSeq	NP_001036053	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001036053
RefSeq	NP_005692	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005692
SMR	O95149	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O95149
STRING	9606.ENSP00000309831	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000309831&targetmode=cogs
UCSC	uc002ban	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ban&org=rat
UniGene	Hs.21577	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.21577
UniProtKB	SPN1_HUMAN	http://www.uniprot.org/uniprot/SPN1_HUMAN
UniProtKB-AC	O95149	http://www.uniprot.org/uniprot/O95149
charge	swissprot:SPN1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SPN1_HUMAN
eggNOG	ENOG410XQNJ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQNJ
eggNOG	KOG3132	http://eggnogapi.embl.de/nog_data/html/tree/KOG3132
epestfind	swissprot:SPN1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SPN1_HUMAN
garnier	swissprot:SPN1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SPN1_HUMAN
helixturnhelix	swissprot:SPN1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SPN1_HUMAN
hmoment	swissprot:SPN1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SPN1_HUMAN
iep	swissprot:SPN1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SPN1_HUMAN
inforesidue	swissprot:SPN1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SPN1_HUMAN
neXtProt	NX_O95149	http://www.nextprot.org/db/entry/NX_O95149
octanol	swissprot:SPN1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SPN1_HUMAN
pepcoil	swissprot:SPN1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SPN1_HUMAN
pepdigest	swissprot:SPN1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SPN1_HUMAN
pepinfo	swissprot:SPN1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SPN1_HUMAN
pepnet	swissprot:SPN1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SPN1_HUMAN
pepstats	swissprot:SPN1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SPN1_HUMAN
pepwheel	swissprot:SPN1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SPN1_HUMAN
pepwindow	swissprot:SPN1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SPN1_HUMAN
sigcleave	swissprot:SPN1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SPN1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GBRG3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99928-1; Sequence=Displayed; Name=2; IsoId=Q99928-2; Sequence=VSP_047543, VSP_047544; Note=No experimental confirmation available.; 
# AltName	GBRG3_HUMAN	GABA(A) receptor subunit gamma-3
# CCDS	CCDS45195	-. [Q99928-1]
# CCDS	CCDS59251	-. [Q99928-2]
# ChiTaRS	GABRG3	human
# DrugBank	DB00186	Lorazepam
# DrugBank	DB00189	Ethchlorvynol
# DrugBank	DB00228	Enflurane
# DrugBank	DB00231	Temazepam
# DrugBank	DB00237	Butabarbital
# DrugBank	DB00241	Butalbital
# DrugBank	DB00273	Topiramate
# DrugBank	DB00292	Etomidate
# DrugBank	DB00306	Talbutal
# DrugBank	DB00312	Pentobarbital
# DrugBank	DB00334	Olanzapine
# DrugBank	DB00349	Clobazam
# DrugBank	DB00371	Meprobamate
# DrugBank	DB00402	Eszopiclone
# DrugBank	DB00404	Alprazolam
# DrugBank	DB00475	Chlordiazepoxide
# DrugBank	DB00543	Amoxapine
# DrugBank	DB00546	Adinazolam
# DrugBank	DB00628	Clorazepate
# DrugBank	DB00659	Acamprosate
# DrugBank	DB00683	Midazolam
# DrugBank	DB00690	Flurazepam
# DrugBank	DB00753	Isoflurane
# DrugBank	DB00794	Primidone
# DrugBank	DB00801	Halazepam
# DrugBank	DB00818	Propofol
# DrugBank	DB00829	Diazepam
# DrugBank	DB00842	Oxazepam
# DrugBank	DB00897	Triazolam
# DrugBank	DB00898	Ethanol
# DrugBank	DB01028	Methoxyflurane
# DrugBank	DB01049	Ergoloid mesylate
# DrugBank	DB01068	Clonazepam
# DrugBank	DB01107	Methyprylon
# DrugBank	DB01159	Halothane
# DrugBank	DB01189	Desflurane
# DrugBank	DB01205	Flumazenil
# DrugBank	DB01215	Estazolam
# DrugBank	DB01236	Sevoflurane
# DrugBank	DB01437	Glutethimide
# DrugBank	DB01558	Bromazepam
# DrugBank	DB01559	Clotiazepam
# DrugBank	DB01567	Fludiazepam
# DrugBank	DB01588	Prazepam
# DrugBank	DB01589	Quazepam
# DrugBank	DB01594	Cinolazepam
# DrugBank	DB01595	Nitrazepam
# Ensembl	ENST00000555083	ENSP00000452244; ENSG00000182256. [Q99928-2]
# Ensembl	ENST00000615808	ENSP00000479113; ENSG00000182256. [Q99928-1]
# ExpressionAtlas	Q99928	baseline and differential
# FUNCTION	GBRG3_HUMAN	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:1902711	GABA-A receptor complex; IBA:GO_Central.
# GO_function	GO:0004890	GABA-A receptor activity; IEA:InterPro.
# GO_function	GO:0005230	extracellular ligand-gated ion channel activity; IEA:InterPro.
# GO_function	GO:0005254	chloride channel activity; IEA:UniProtKB-KW.
# GO_process	GO:0007214	gamma-aminobutyric acid signaling pathway; IEA:InterPro.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.70.170.10	-; 1.
# Genevisible	Q99928	HS
# HGNC	HGNC:4088	GABRG3
# InterPro	IPR005437	GABBAg_rcpt
# InterPro	IPR005440	GABBAg3_rcpt
# InterPro	IPR006028	GABAA/Glycine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04727	GABAergic synapse
# KEGG_Pathway	ko05032	Morphine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# MIM	600233	gene
# MISCELLANEOUS	GBRG3_HUMAN	This subunit carries the benzodiazepine binding site. 
# Organism	GBRG3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR18945	PTHR18945; 2
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00253	GABAARECEPTR
# PRINTS	PR01620	GABAARGAMMA
# PRINTS	PR01623	GABAARGAMMA3
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# PTM	GBRG3_HUMAN	May be palmitoylated. {ECO 0000250}. 
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 15
# Reactome	R-HSA-112314	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
# Reactome	R-HSA-975298	Ligand-gated ion channel transport
# Reactome	R-HSA-977441	GABA A receptor activation
# RecName	GBRG3_HUMAN	Gamma-aminobutyric acid receptor subunit gamma-3
# RefSeq	NP_001257802	NM_001270873.1. [Q99928-2]
# RefSeq	NP_150092	NM_033223.4. [Q99928-1]
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG3 sub-subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	GBRG3_HUMAN	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Generally pentameric. There are five types of GABA(A) receptor chains	 alpha, beta, gamma, delta, and rho. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TIGRFAMs	TIGR00860	LIC
# UCSC	uc001zbf	human. [Q99928-1]
# WEB RESOURCE	GBRG3_HUMAN	Name=Protein Spotlight; Note=Forbidden fruit - Issue 56 of March 2005; URL="http //web.expasy.org/spotlight/back_issues/056";
# eggNOG	ENOG410XNQG	LUCA
# eggNOG	KOG3642	Eukaryota
BLAST	swissprot:GBRG3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GBRG3_HUMAN
BioCyc	ZFISH:G66-32894-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32894-MONOMER
COXPRESdb	2567	http://coxpresdb.jp/data/gene/2567.shtml
CleanEx	HS_GABRG3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GABRG3
DOI	10.1016/0922-4106(95)90070-5	http://dx.doi.org/10.1016/0922-4106(95)90070-5
DOI	10.1038/nature04601	http://dx.doi.org/10.1038/nature04601
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1136/jmedgenet-2015-103179	http://dx.doi.org/10.1136/jmedgenet-2015-103179
DrugBank	DB00186	http://www.drugbank.ca/drugs/DB00186
DrugBank	DB00189	http://www.drugbank.ca/drugs/DB00189
DrugBank	DB00228	http://www.drugbank.ca/drugs/DB00228
DrugBank	DB00231	http://www.drugbank.ca/drugs/DB00231
DrugBank	DB00237	http://www.drugbank.ca/drugs/DB00237
DrugBank	DB00241	http://www.drugbank.ca/drugs/DB00241
DrugBank	DB00273	http://www.drugbank.ca/drugs/DB00273
DrugBank	DB00292	http://www.drugbank.ca/drugs/DB00292
DrugBank	DB00306	http://www.drugbank.ca/drugs/DB00306
DrugBank	DB00312	http://www.drugbank.ca/drugs/DB00312
DrugBank	DB00334	http://www.drugbank.ca/drugs/DB00334
DrugBank	DB00349	http://www.drugbank.ca/drugs/DB00349
DrugBank	DB00371	http://www.drugbank.ca/drugs/DB00371
DrugBank	DB00402	http://www.drugbank.ca/drugs/DB00402
DrugBank	DB00404	http://www.drugbank.ca/drugs/DB00404
DrugBank	DB00475	http://www.drugbank.ca/drugs/DB00475
DrugBank	DB00543	http://www.drugbank.ca/drugs/DB00543
DrugBank	DB00546	http://www.drugbank.ca/drugs/DB00546
DrugBank	DB00628	http://www.drugbank.ca/drugs/DB00628
DrugBank	DB00659	http://www.drugbank.ca/drugs/DB00659
DrugBank	DB00683	http://www.drugbank.ca/drugs/DB00683
DrugBank	DB00690	http://www.drugbank.ca/drugs/DB00690
DrugBank	DB00753	http://www.drugbank.ca/drugs/DB00753
DrugBank	DB00794	http://www.drugbank.ca/drugs/DB00794
DrugBank	DB00801	http://www.drugbank.ca/drugs/DB00801
DrugBank	DB00818	http://www.drugbank.ca/drugs/DB00818
DrugBank	DB00829	http://www.drugbank.ca/drugs/DB00829
DrugBank	DB00842	http://www.drugbank.ca/drugs/DB00842
DrugBank	DB00897	http://www.drugbank.ca/drugs/DB00897
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01028	http://www.drugbank.ca/drugs/DB01028
DrugBank	DB01049	http://www.drugbank.ca/drugs/DB01049
DrugBank	DB01068	http://www.drugbank.ca/drugs/DB01068
DrugBank	DB01107	http://www.drugbank.ca/drugs/DB01107
DrugBank	DB01159	http://www.drugbank.ca/drugs/DB01159
DrugBank	DB01189	http://www.drugbank.ca/drugs/DB01189
DrugBank	DB01205	http://www.drugbank.ca/drugs/DB01205
DrugBank	DB01215	http://www.drugbank.ca/drugs/DB01215
DrugBank	DB01236	http://www.drugbank.ca/drugs/DB01236
DrugBank	DB01437	http://www.drugbank.ca/drugs/DB01437
DrugBank	DB01558	http://www.drugbank.ca/drugs/DB01558
DrugBank	DB01559	http://www.drugbank.ca/drugs/DB01559
DrugBank	DB01567	http://www.drugbank.ca/drugs/DB01567
DrugBank	DB01588	http://www.drugbank.ca/drugs/DB01588
DrugBank	DB01589	http://www.drugbank.ca/drugs/DB01589
DrugBank	DB01594	http://www.drugbank.ca/drugs/DB01594
DrugBank	DB01595	http://www.drugbank.ca/drugs/DB01595
EMBL	AC104002	http://www.ebi.ac.uk/ena/data/view/AC104002
EMBL	AC127511	http://www.ebi.ac.uk/ena/data/view/AC127511
EMBL	AC135326	http://www.ebi.ac.uk/ena/data/view/AC135326
EMBL	AC136896	http://www.ebi.ac.uk/ena/data/view/AC136896
EMBL	AC144833	http://www.ebi.ac.uk/ena/data/view/AC144833
EMBL	AC145436	http://www.ebi.ac.uk/ena/data/view/AC145436
EMBL	AF269135	http://www.ebi.ac.uk/ena/data/view/AF269135
EMBL	AF269136	http://www.ebi.ac.uk/ena/data/view/AF269136
EMBL	AF269137	http://www.ebi.ac.uk/ena/data/view/AF269137
EMBL	AF269138	http://www.ebi.ac.uk/ena/data/view/AF269138
EMBL	AF269139	http://www.ebi.ac.uk/ena/data/view/AF269139
EMBL	AF269140	http://www.ebi.ac.uk/ena/data/view/AF269140
EMBL	AF269141	http://www.ebi.ac.uk/ena/data/view/AF269141
EMBL	AF269142	http://www.ebi.ac.uk/ena/data/view/AF269142
EMBL	AF269143	http://www.ebi.ac.uk/ena/data/view/AF269143
EMBL	AF269144	http://www.ebi.ac.uk/ena/data/view/AF269144
EMBL	AH009226	http://www.ebi.ac.uk/ena/data/view/AH009226
EMBL	BC045709	http://www.ebi.ac.uk/ena/data/view/BC045709
EMBL	CH471151	http://www.ebi.ac.uk/ena/data/view/CH471151
EMBL	EU606049	http://www.ebi.ac.uk/ena/data/view/EU606049
EMBL	S82769	http://www.ebi.ac.uk/ena/data/view/S82769
Ensembl	ENST00000555083	http://www.ensembl.org/id/ENST00000555083
Ensembl	ENST00000615808	http://www.ensembl.org/id/ENST00000615808
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_component	GO:1902711	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902711
GO_function	GO:0004890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004890
GO_function	GO:0005230	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005230
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_process	GO:0007214	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007214
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	GABRG3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GABRG3
GeneID	2567	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2567
GeneTree	ENSGT00760000119010	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119010
H-InvDB	HIX0026811	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0026811
HGNC	HGNC:4088	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4088
HOGENOM	HOG000231337	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231337&db=HOGENOM6
HOVERGEN	HBG051707	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051707&db=HOVERGEN
HPA	HPA054010	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA054010
InParanoid	Q99928	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q99928
InterPro	IPR005437	http://www.ebi.ac.uk/interpro/entry/IPR005437
InterPro	IPR005440	http://www.ebi.ac.uk/interpro/entry/IPR005440
InterPro	IPR006028	http://www.ebi.ac.uk/interpro/entry/IPR006028
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
Jabion	2567	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2567
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:2567	http://www.genome.jp/dbget-bin/www_bget?hsa:2567
KEGG_Orthology	KO:K05186	http://www.genome.jp/dbget-bin/www_bget?KO:K05186
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
KEGG_Pathway	ko05032	http://www.genome.jp/kegg-bin/show_pathway?ko05032
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
MIM	600233	http://www.ncbi.nlm.nih.gov/omim/600233
OMA	MYWQDFE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MYWQDFE
OrthoDB	EOG091G0805	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0805
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00253	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00253
PRINTS	PR01620	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01620
PRINTS	PR01623	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01623
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:GBRG3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GBRG3_HUMAN
PSORT-B	swissprot:GBRG3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GBRG3_HUMAN
PSORT2	swissprot:GBRG3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GBRG3_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA28502	http://www.pharmgkb.org/do/serve?objId=PA28502&objCls=Gene
Phobius	swissprot:GBRG3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GBRG3_HUMAN
PhylomeDB	Q99928	http://phylomedb.org/?seqid=Q99928
ProteinModelPortal	Q99928	http://www.proteinmodelportal.org/query/uniprot/Q99928
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16572171	http://www.ncbi.nlm.nih.gov/pubmed/16572171
PubMed	26566883	http://www.ncbi.nlm.nih.gov/pubmed/26566883
PubMed	8719414	http://www.ncbi.nlm.nih.gov/pubmed/8719414
Reactome	R-HSA-112314	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112314
Reactome	R-HSA-975298	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-975298
Reactome	R-HSA-977441	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-977441
RefSeq	NP_001257802	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001257802
RefSeq	NP_150092	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_150092
SMR	Q99928	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q99928
STRING	9606.ENSP00000331912	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000331912&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc001zbf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001zbf&org=rat
UniGene	Hs.569475	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.569475
UniProtKB	GBRG3_HUMAN	http://www.uniprot.org/uniprot/GBRG3_HUMAN
UniProtKB-AC	Q99928	http://www.uniprot.org/uniprot/Q99928
charge	swissprot:GBRG3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GBRG3_HUMAN
eggNOG	ENOG410XNQG	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNQG
eggNOG	KOG3642	http://eggnogapi.embl.de/nog_data/html/tree/KOG3642
epestfind	swissprot:GBRG3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GBRG3_HUMAN
garnier	swissprot:GBRG3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GBRG3_HUMAN
helixturnhelix	swissprot:GBRG3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GBRG3_HUMAN
hmoment	swissprot:GBRG3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GBRG3_HUMAN
iep	swissprot:GBRG3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GBRG3_HUMAN
inforesidue	swissprot:GBRG3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GBRG3_HUMAN
neXtProt	NX_Q99928	http://www.nextprot.org/db/entry/NX_Q99928
octanol	swissprot:GBRG3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GBRG3_HUMAN
pepcoil	swissprot:GBRG3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GBRG3_HUMAN
pepdigest	swissprot:GBRG3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GBRG3_HUMAN
pepinfo	swissprot:GBRG3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GBRG3_HUMAN
pepnet	swissprot:GBRG3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GBRG3_HUMAN
pepstats	swissprot:GBRG3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GBRG3_HUMAN
pepwheel	swissprot:GBRG3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GBRG3_HUMAN
pepwindow	swissprot:GBRG3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GBRG3_HUMAN
sigcleave	swissprot:GBRG3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GBRG3_HUMAN
## Database	ID	URL or Descriptions
# AltName	CTR4_HUMAN	Solute carrier family 7 member 4
# DrugBank	DB00123	L-Lysine
# DrugBank	DB00125	L-Arginine
# DrugBank	DB00129	L-Ornithine
# Ensembl	ENST00000382932	ENSP00000372390; ENSG00000099960
# Ensembl	ENST00000403586	ENSP00000384278; ENSG00000099960
# ExpressionAtlas	O43246	baseline and differential
# FUNCTION	CTR4_HUMAN	Involved in the transport of the cationic amino acids (arginine, lysine and ornithine). 
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_function	GO:0015174	basic amino acid transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0015179	L-amino acid transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015297	antiporter activity; IBA:GO_Central.
# GO_process	GO:0006520	cellular amino acid metabolic process; TAS:ProtInc.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006520	cellular amino acid metabolic process
# GOslim_process	GO:0006810	transport
# Genevisible	O43246	HS
# HGNC	HGNC:11062	SLC7A4
# InterPro	IPR002293	AA/rel_permease1
# InterPro	IPR029485	CAT_C
# KEGG_Brite	ko02001	Solute carrier family
# MIM	603752	gene
# Organism	CTR4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11785	PTHR11785; 3
# Pfam	PF13520	AA_permease_2
# Pfam	PF13906	AA_permease_C
# Proteomes	UP000005640	Chromosome 22
# RecName	CTR4_HUMAN	Cationic amino acid transporter 4
# RefSeq	NP_004164	NM_004173.2
# SIMILARITY	Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	CTR4_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	2.A.3.3	the amino acid-polyamine-organocation (apc) family
# UCSC	uc002zud	human
# eggNOG	COG0531	LUCA
# eggNOG	KOG1286	Eukaryota
BLAST	swissprot:CTR4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CTR4_HUMAN
BioCyc	ZFISH:ENSG00000099960-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000099960-MONOMER
COXPRESdb	6545	http://coxpresdb.jp/data/gene/6545.shtml
CleanEx	HS_SLC7A4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC7A4
DOI	10.1006/geno.1998.5252	http://dx.doi.org/10.1006/geno.1998.5252
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/gb-2004-5-10-r84	http://dx.doi.org/10.1186/gb-2004-5-10-r84
DrugBank	DB00123	http://www.drugbank.ca/drugs/DB00123
DrugBank	DB00125	http://www.drugbank.ca/drugs/DB00125
DrugBank	DB00129	http://www.drugbank.ca/drugs/DB00129
EMBL	AJ000730	http://www.ebi.ac.uk/ena/data/view/AJ000730
EMBL	BC008814	http://www.ebi.ac.uk/ena/data/view/BC008814
EMBL	BC062565	http://www.ebi.ac.uk/ena/data/view/BC062565
EMBL	BC107160	http://www.ebi.ac.uk/ena/data/view/BC107160
EMBL	BC107161	http://www.ebi.ac.uk/ena/data/view/BC107161
EMBL	CR456580	http://www.ebi.ac.uk/ena/data/view/CR456580
Ensembl	ENST00000382932	http://www.ensembl.org/id/ENST00000382932
Ensembl	ENST00000403586	http://www.ensembl.org/id/ENST00000403586
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015174	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015174
GO_function	GO:0015179	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015179
GO_function	GO:0015297	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297
GO_process	GO:0006520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC7A4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC7A4
GeneID	6545	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6545
GeneTree	ENSGT00760000119151	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119151
HGNC	HGNC:11062	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11062
HOGENOM	HOG000250623	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000250623&db=HOGENOM6
HOVERGEN	HBG000280	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000280&db=HOVERGEN
HPA	HPA031023	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031023
InParanoid	O43246	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O43246
InterPro	IPR002293	http://www.ebi.ac.uk/interpro/entry/IPR002293
InterPro	IPR029485	http://www.ebi.ac.uk/interpro/entry/IPR029485
Jabion	6545	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6545
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6545	http://www.genome.jp/dbget-bin/www_bget?hsa:6545
KEGG_Orthology	KO:K13866	http://www.genome.jp/dbget-bin/www_bget?KO:K13866
MIM	603752	http://www.ncbi.nlm.nih.gov/omim/603752
MINT	MINT-2999274	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-2999274
OMA	QDPGHME	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QDPGHME
OrthoDB	EOG091G05NM	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05NM
PANTHER	PTHR11785	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785
PSORT	swissprot:CTR4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CTR4_HUMAN
PSORT-B	swissprot:CTR4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CTR4_HUMAN
PSORT2	swissprot:CTR4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CTR4_HUMAN
Pfam	PF13520	http://pfam.xfam.org/family/PF13520
Pfam	PF13906	http://pfam.xfam.org/family/PF13906
PharmGKB	PA35922	http://www.pharmgkb.org/do/serve?objId=PA35922&objCls=Gene
Phobius	swissprot:CTR4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CTR4_HUMAN
PhylomeDB	O43246	http://phylomedb.org/?seqid=O43246
ProteinModelPortal	O43246	http://www.proteinmodelportal.org/query/uniprot/O43246
PubMed	15461802	http://www.ncbi.nlm.nih.gov/pubmed/15461802
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	9598310	http://www.ncbi.nlm.nih.gov/pubmed/9598310
RefSeq	NP_004164	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004164
STRING	9606.ENSP00000372390	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000372390&targetmode=cogs
TCDB	2.A.3.3	http://www.tcdb.org/search/result.php?tc=2.A.3.3
UCSC	uc002zud	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002zud&org=rat
UniGene	Hs.197116	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.197116
UniProtKB	CTR4_HUMAN	http://www.uniprot.org/uniprot/CTR4_HUMAN
UniProtKB-AC	O43246	http://www.uniprot.org/uniprot/O43246
charge	swissprot:CTR4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CTR4_HUMAN
eggNOG	COG0531	http://eggnogapi.embl.de/nog_data/html/tree/COG0531
eggNOG	KOG1286	http://eggnogapi.embl.de/nog_data/html/tree/KOG1286
epestfind	swissprot:CTR4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CTR4_HUMAN
garnier	swissprot:CTR4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CTR4_HUMAN
helixturnhelix	swissprot:CTR4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CTR4_HUMAN
hmoment	swissprot:CTR4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CTR4_HUMAN
iep	swissprot:CTR4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CTR4_HUMAN
inforesidue	swissprot:CTR4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CTR4_HUMAN
neXtProt	NX_O43246	http://www.nextprot.org/db/entry/NX_O43246
octanol	swissprot:CTR4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CTR4_HUMAN
pepcoil	swissprot:CTR4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CTR4_HUMAN
pepdigest	swissprot:CTR4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CTR4_HUMAN
pepinfo	swissprot:CTR4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CTR4_HUMAN
pepnet	swissprot:CTR4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CTR4_HUMAN
pepstats	swissprot:CTR4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CTR4_HUMAN
pepwheel	swissprot:CTR4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CTR4_HUMAN
pepwindow	swissprot:CTR4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CTR4_HUMAN
sigcleave	swissprot:CTR4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CTR4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SL9B2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q86UD5-1; Sequence=Displayed; Name=2; IsoId=Q86UD5-2; Sequence=VSP_033152, VSP_033153; Note=No experimental confirmation available.; 
# AltName	SL9B2_HUMAN	Mitochondrial Na(+)/H(+) exchanger NHA2
# AltName	SL9B2_HUMAN	Na(+)/H(+) exchanger-like domain-containing protein 2
# AltName	SL9B2_HUMAN	Sodium/hydrogen exchanger-like domain-containing protein 2
# AltName	SL9B2_HUMAN	Solute carrier family 9 subfamily B member 2
# CCDS	CCDS3662	-. [Q86UD5-1]
# ChiTaRS	SLC9B2	human
# Ensembl	ENST00000362026	ENSP00000354574; ENSG00000164038. [Q86UD5-1]
# Ensembl	ENST00000394785	ENSP00000378265; ENSG00000164038. [Q86UD5-1]
# ExpressionAtlas	Q86UD5	baseline and differential
# FUNCTION	SL9B2_HUMAN	Electroneutral exchange of protons for Na(+) and Li(+) across the inner mitochondrial membrane. Contributes to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption activity (By similarity). {ECO 0000250, ECO 0000269|PubMed 18000046}. 
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	SL9B2_HUMAN	GO 0005451 monovalent cation proton antiporter activity; TAS Reactome.
# GO_process	GO:0006814	sodium ion transport; IEA:UniProtKB-KW.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:2001206	positive regulation of osteoclast development; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q86UD5	HS
# HGNC	HGNC:25143	SLC9B2
# IntAct	Q86UD5	3
# InterPro	IPR006153	Cation/H_exchanger
# InterPro	IPR030187	NHA2
# MIM	611789	gene
# Organism	SL9B2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR31102:SF6	PTHR31102:SF6
# Pfam	PF00999	Na_H_Exchanger
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	SL9B2_HUMAN	Mitochondrial sodium/hydrogen exchanger 9B2
# RefSeq	NP_001287685	NM_001300756.1
# RefSeq	NP_849155	NM_178833.5. [Q86UD5-1]
# RefSeq	XP_006714148	XM_006714085.2. [Q86UD5-1]
# SIMILARITY	Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	SL9B2_HUMAN	Mitochondrion membrane {ECO 0000250}; Multi- pass membrane protein {ECO 0000250}. 
# TCDB	2.A.36.2:the monovalent cation	proton antiporter-1 (cpa1) family
# TISSUE SPECIFICITY	SL9B2_HUMAN	Detected in red blood cells (at protein level). 
# UCSC	uc003hwx	human. [Q86UD5-1]
# eggNOG	COG0025	LUCA
# eggNOG	KOG3826	Eukaryota
BLAST	swissprot:SL9B2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SL9B2_HUMAN
COXPRESdb	133308	http://coxpresdb.jp/data/gene/133308.shtml
CleanEx	HS_NHEDC2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_NHEDC2
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0707120104	http://dx.doi.org/10.1073/pnas.0707120104
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC097485	http://www.ebi.ac.uk/ena/data/view/AC097485
EMBL	AK172823	http://www.ebi.ac.uk/ena/data/view/AK172823
EMBL	BC009732	http://www.ebi.ac.uk/ena/data/view/BC009732
EMBL	BC047447	http://www.ebi.ac.uk/ena/data/view/BC047447
EMBL	CH471057	http://www.ebi.ac.uk/ena/data/view/CH471057
Ensembl	ENST00000362026	http://www.ensembl.org/id/ENST00000362026
Ensembl	ENST00000394785	http://www.ensembl.org/id/ENST00000394785
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005451	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005451
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:2001206	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001206
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC9B2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC9B2
GeneID	133308	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=133308
GeneTree	ENSGT00390000013285	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000013285
HGNC	HGNC:25143	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:25143
HOGENOM	HOG000060325	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000060325&db=HOGENOM6
HOVERGEN	HBG108184	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108184&db=HOVERGEN
HPA	HPA047008	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA047008
InParanoid	Q86UD5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q86UD5
IntAct	Q86UD5	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q86UD5*
InterPro	IPR006153	http://www.ebi.ac.uk/interpro/entry/IPR006153
InterPro	IPR030187	http://www.ebi.ac.uk/interpro/entry/IPR030187
Jabion	133308	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=133308
KEGG_Gene	hsa:133308	http://www.genome.jp/dbget-bin/www_bget?hsa:133308
MIM	611789	http://www.ncbi.nlm.nih.gov/omim/611789
OMA	KIVAVAW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KIVAVAW
OrthoDB	EOG091G06PH	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G06PH
PANTHER	PTHR31102:SF6	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31102:SF6
PSORT	swissprot:SL9B2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SL9B2_HUMAN
PSORT-B	swissprot:SL9B2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SL9B2_HUMAN
PSORT2	swissprot:SL9B2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SL9B2_HUMAN
Pfam	PF00999	http://pfam.xfam.org/family/PF00999
PharmGKB	PA162397515	http://www.pharmgkb.org/do/serve?objId=PA162397515&objCls=Gene
Phobius	swissprot:SL9B2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SL9B2_HUMAN
PhylomeDB	Q86UD5	http://phylomedb.org/?seqid=Q86UD5
ProteinModelPortal	Q86UD5	http://www.proteinmodelportal.org/query/uniprot/Q86UD5
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	18000046	http://www.ncbi.nlm.nih.gov/pubmed/18000046
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_001287685	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001287685
RefSeq	NP_849155	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_849155
RefSeq	XP_006714148	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006714148
STRING	9606.ENSP00000354574	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000354574&targetmode=cogs
TCDB	2.A.36.2	http://www.tcdb.org/search/result.php?tc=2.A.36.2
UCSC	uc003hwx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003hwx&org=rat
UniGene	Hs.546482	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.546482
UniProtKB	SL9B2_HUMAN	http://www.uniprot.org/uniprot/SL9B2_HUMAN
UniProtKB-AC	Q86UD5	http://www.uniprot.org/uniprot/Q86UD5
charge	swissprot:SL9B2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SL9B2_HUMAN
eggNOG	COG0025	http://eggnogapi.embl.de/nog_data/html/tree/COG0025
eggNOG	KOG3826	http://eggnogapi.embl.de/nog_data/html/tree/KOG3826
epestfind	swissprot:SL9B2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SL9B2_HUMAN
garnier	swissprot:SL9B2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SL9B2_HUMAN
helixturnhelix	swissprot:SL9B2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SL9B2_HUMAN
hmoment	swissprot:SL9B2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SL9B2_HUMAN
iep	swissprot:SL9B2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SL9B2_HUMAN
inforesidue	swissprot:SL9B2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SL9B2_HUMAN
neXtProt	NX_Q86UD5	http://www.nextprot.org/db/entry/NX_Q86UD5
octanol	swissprot:SL9B2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SL9B2_HUMAN
pepcoil	swissprot:SL9B2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SL9B2_HUMAN
pepdigest	swissprot:SL9B2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SL9B2_HUMAN
pepinfo	swissprot:SL9B2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SL9B2_HUMAN
pepnet	swissprot:SL9B2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SL9B2_HUMAN
pepstats	swissprot:SL9B2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SL9B2_HUMAN
pepwheel	swissprot:SL9B2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SL9B2_HUMAN
pepwindow	swissprot:SL9B2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SL9B2_HUMAN
sigcleave	swissprot:SL9B2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SL9B2_HUMAN
## Database	ID	URL or Descriptions
# AltName	COX42_HUMAN	Cytochrome c oxidase subunit IV isoform 2
# BioGrid	124215	3
# CDD	cd00922	Cyt_c_Oxidase_IV
# DISEASE	COX42_HUMAN	Exocrine pancreatic insufficiency dyserythropoietic anemia and calvarial hyperostosis (EPIDACH) [MIM 612714]  Patients present with pancreatic insufficiency, intestinal malabsorption, failure to thrive, and anemia soon after birth. {ECO 0000269|PubMed 19268275}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000376075	ENSP00000365243; ENSG00000131055
# ExpressionAtlas	Q96KJ9	baseline and differential
# FUNCTION	COX42_HUMAN	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. 
# GO_component	GO:0005751	mitochondrial respiratory chain complex IV; IC:UniProtKB.
# GO_function	GO:0004129	cytochrome-c oxidase activity; IDA:UniProtKB.
# GO_process	GO:0006091	generation of precursor metabolites and energy; NAS:UniProtKB.
# GO_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen; IBA:GO_Central.
# GO_process	GO:0045333	cellular respiration; NAS:UniProtKB.
# GO_process	GO:0055114	oxidation-reduction process; NAS:UniProtKB.
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.10.442.10	-; 1.
# Genevisible	Q96KJ9	HS
# HGNC	HGNC:16232	COX4I2
# InterPro	IPR004203	Cyt_c_oxidase_su4_fam
# InterPro	IPR013288	Cyt_c_oxidase_su4
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Disease	H00920	[Metabolic disease; Pancreas disease; Hematologic disease; Skeletal dysplasia] Exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	607976	gene
# MIM	612714	phenotype
# Organism	COX42_HUMAN	Homo sapiens (Human)
# Orphanet	199337	Pancreatic insufficiency - anemia - hyperostosis
# PANTHER	PTHR10707	PTHR10707
# PRINTS	PR01873	CYTCOXIDASE4
# Pfam	PF02936	COX4
# Proteomes	UP000005640	Chromosome 20
# RecName	COX42_HUMAN	Cytochrome c oxidase subunit 4 isoform 2, mitochondrial
# RefSeq	NP_115998	NM_032609.2
# SIMILARITY	Belongs to the cytochrome c oxidase IV family. {ECO	0000305}.
# SUBCELLULAR LOCATION	COX42_HUMAN	Mitochondrion inner membrane. 
# SUPFAM	SSF81406	SSF81406
# TCDB	3.D.4.11	the proton-translocating cytochrome oxidase (cox) superfamily
# TISSUE SPECIFICITY	COX42_HUMAN	Highly expressed in lung. 
# UCSC	uc002wwj	human
# eggNOG	ENOG4111T97	LUCA
# eggNOG	KOG4075	Eukaryota
BLAST	swissprot:COX42_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:COX42_HUMAN
BioCyc	ZFISH:HS05480-MONOMER	http://biocyc.org/getid?id=ZFISH:HS05480-MONOMER
COXPRESdb	84701	http://coxpresdb.jp/data/gene/84701.shtml
CleanEx	HS_COX4I2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_COX4I2
DOI	10.1016/S0378-1119(01)00385-7	http://dx.doi.org/10.1016/S0378-1119(01)00385-7
DOI	10.1016/j.ajhg.2009.02.006	http://dx.doi.org/10.1016/j.ajhg.2009.02.006
DOI	10.1038/414865a	http://dx.doi.org/10.1038/414865a
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF257180	http://www.ebi.ac.uk/ena/data/view/AF257180
EMBL	AL117381	http://www.ebi.ac.uk/ena/data/view/AL117381
EMBL	BC057779	http://www.ebi.ac.uk/ena/data/view/BC057779
Ensembl	ENST00000376075	http://www.ensembl.org/id/ENST00000376075
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005751	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005751
GO_function	GO:0004129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004129
GO_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GO_process	GO:0006123	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006123
GO_process	GO:0045333	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045333
GO_process	GO:0055114	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.10.442.10	http://www.cathdb.info/version/latest/superfamily/1.10.442.10
GeneCards	COX4I2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=COX4I2
GeneID	84701	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84701
GeneTree	ENSGT00390000002407	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002407
HGNC	HGNC:16232	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16232
HOGENOM	HOG000231486	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231486&db=HOGENOM6
HOVERGEN	HBG051087	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051087&db=HOVERGEN
HPA	HPA029307	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA029307
InParanoid	Q96KJ9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96KJ9
InterPro	IPR004203	http://www.ebi.ac.uk/interpro/entry/IPR004203
InterPro	IPR013288	http://www.ebi.ac.uk/interpro/entry/IPR013288
Jabion	84701	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=84701
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Disease	H00920	http://www.genome.jp/dbget-bin/www_bget?H00920
KEGG_Gene	hsa:84701	http://www.genome.jp/dbget-bin/www_bget?hsa:84701
KEGG_Orthology	KO:K02263	http://www.genome.jp/dbget-bin/www_bget?KO:K02263
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	607976	http://www.ncbi.nlm.nih.gov/omim/607976
MIM	612714	http://www.ncbi.nlm.nih.gov/omim/612714
OMA	DYERKEW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DYERKEW
Orphanet	199337	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=199337
OrthoDB	EOG091G0XDH	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0XDH
PANTHER	PTHR10707	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10707
PRINTS	PR01873	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01873
PSORT	swissprot:COX42_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:COX42_HUMAN
PSORT-B	swissprot:COX42_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:COX42_HUMAN
PSORT2	swissprot:COX42_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:COX42_HUMAN
Pfam	PF02936	http://pfam.xfam.org/family/PF02936
PharmGKB	PA26783	http://www.pharmgkb.org/do/serve?objId=PA26783&objCls=Gene
Phobius	swissprot:COX42_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:COX42_HUMAN
PhylomeDB	Q96KJ9	http://phylomedb.org/?seqid=Q96KJ9
ProteinModelPortal	Q96KJ9	http://www.proteinmodelportal.org/query/uniprot/Q96KJ9
PubMed	11311561	http://www.ncbi.nlm.nih.gov/pubmed/11311561
PubMed	11780052	http://www.ncbi.nlm.nih.gov/pubmed/11780052
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19268275	http://www.ncbi.nlm.nih.gov/pubmed/19268275
RefSeq	NP_115998	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_115998
SMR	Q96KJ9	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q96KJ9
STRING	9606.ENSP00000365243	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000365243&targetmode=cogs
SUPFAM	SSF81406	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81406
TCDB	3.D.4.11	http://www.tcdb.org/search/result.php?tc=3.D.4.11
UCSC	uc002wwj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002wwj&org=rat
UniGene	Hs.277101	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.277101
UniProtKB	COX42_HUMAN	http://www.uniprot.org/uniprot/COX42_HUMAN
UniProtKB-AC	Q96KJ9	http://www.uniprot.org/uniprot/Q96KJ9
charge	swissprot:COX42_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:COX42_HUMAN
eggNOG	ENOG4111T97	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111T97
eggNOG	KOG4075	http://eggnogapi.embl.de/nog_data/html/tree/KOG4075
epestfind	swissprot:COX42_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:COX42_HUMAN
garnier	swissprot:COX42_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:COX42_HUMAN
helixturnhelix	swissprot:COX42_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:COX42_HUMAN
hmoment	swissprot:COX42_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:COX42_HUMAN
iep	swissprot:COX42_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:COX42_HUMAN
inforesidue	swissprot:COX42_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:COX42_HUMAN
neXtProt	NX_Q96KJ9	http://www.nextprot.org/db/entry/NX_Q96KJ9
octanol	swissprot:COX42_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:COX42_HUMAN
pepcoil	swissprot:COX42_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:COX42_HUMAN
pepdigest	swissprot:COX42_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:COX42_HUMAN
pepinfo	swissprot:COX42_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:COX42_HUMAN
pepnet	swissprot:COX42_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:COX42_HUMAN
pepstats	swissprot:COX42_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:COX42_HUMAN
pepwheel	swissprot:COX42_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:COX42_HUMAN
pepwindow	swissprot:COX42_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:COX42_HUMAN
sigcleave	swissprot:COX42_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:COX42_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S39A1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NY26-1; Sequence=Displayed; Name=2; IsoId=Q9NY26-2; Sequence=VSP_056522; Note=No experimental confirmation available.; 
# AltName	S39A1_HUMAN	Solute carrier family 39 member 1
# AltName	S39A1_HUMAN	Zinc-iron-regulated transporter-like
# AltName	S39A1_HUMAN	Zrt- and Irt-like protein 1
# BioGrid	118050	23
# CCDS	CCDS1055	-. [Q9NY26-1]
# ChiTaRS	SLC39A1	human
# Ensembl	ENST00000310483	ENSP00000309710; ENSG00000143570. [Q9NY26-1]
# Ensembl	ENST00000356205	ENSP00000348535; ENSG00000143570. [Q9NY26-1]
# Ensembl	ENST00000368621	ENSP00000357610; ENSG00000143570. [Q9NY26-1]
# Ensembl	ENST00000368623	ENSP00000357612; ENSG00000143570. [Q9NY26-1]
# Ensembl	ENST00000617697	ENSP00000479421; ENSG00000143570. [Q9NY26-1]
# Ensembl	ENST00000621013	ENSP00000484182; ENSG00000143570. [Q9NY26-1]
# ExpressionAtlas	Q9NY26	baseline and differential
# FUNCTION	S39A1_HUMAN	Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells. {ECO 0000269|PubMed 12888280}. 
# GO_component	GO:0005789	endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_function	GO:0005385	zinc ion transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0022890	inorganic cation transmembrane transporter activity; TAS:ProtInc.
# GO_process	GO:0001701	in utero embryonic development; IEA:Ensembl.
# GO_process	GO:0006812	cation transport; TAS:ProtInc.
# GO_process	GO:0048701	embryonic cranial skeleton morphogenesis; IEA:Ensembl.
# GO_process	GO:0060173	limb development; IEA:Ensembl.
# GO_process	GO:0071577	zinc II ion transmembrane transport; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009790	embryo development
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9NY26	HS
# HGNC	HGNC:12876	SLC39A1
# IntAct	Q9NY26	3
# InterPro	IPR003689	ZIP
# KEGG_Brite	ko02001	Solute carrier family
# MIM	604740	gene
# MISCELLANEOUS	S39A1_HUMAN	Inhibited by Ni(2+) ions. Fe(2+) ions do not inhibit zinc uptake. 
# Organism	S39A1_HUMAN	Homo sapiens (Human)
# Pfam	PF02535	Zip
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-442380	Zinc influx into cells by the SLC39 gene family
# RecName	S39A1_HUMAN	Zinc transporter ZIP1
# RefSeq	NP_001258886	NM_001271957.1. [Q9NY26-1]
# RefSeq	NP_001258887	NM_001271958.1. [Q9NY26-1]
# RefSeq	NP_001258888	NM_001271959.1. [Q9NY26-1]
# RefSeq	NP_001258889	NM_001271960.1. [Q9NY26-1]
# RefSeq	NP_001258890	NM_001271961.1
# RefSeq	NP_055252	NM_014437.4. [Q9NY26-1]
# SEQUENCE CAUTION	Sequence=AAD27717.1; Type=Frameshift; Positions=16, 40; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the ZIP transporter (TC 2.A.5) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S39A1_HUMAN	Cell membrane {ECO 0000269|PubMed 11696349}; Multi-pass membrane protein {ECO 0000269|PubMed 11696349}. Endoplasmic reticulum membrane {ECO 0000269|PubMed 11696349}; Multi-pass membrane protein {ECO 0000269|PubMed 11696349}. Note=Shows a vesicular localization corresponding partially to the endoplasmic reticulum in several epithelial cell lines. 
# TCDB	2.A.5.3	the zinc (zn(2+))-iron (fe(2+)) permease (zip) family
# TISSUE SPECIFICITY	Ubiquitous. Expressed in most adult and fetal tissues including the epidermis. {ECO:0000269|PubMed	10610721}. 
# UCSC	uc001fdi	human. [Q9NY26-1]
# WEB RESOURCE	S39A1_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/SLC39A1ID46571ch1q21.html";
# eggNOG	ENOG4111GP2	LUCA
# eggNOG	KOG1558	Eukaryota
BLAST	swissprot:S39A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S39A1_HUMAN
BioCyc	ZFISH:ENSG00000143570-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000143570-MONOMER
COXPRESdb	27173	http://coxpresdb.jp/data/gene/27173.shtml
CleanEx	HS_SLC39A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC39A1
DOI	10.1006/geno.1999.5993	http://dx.doi.org/10.1006/geno.1999.5993
DOI	10.1016/S0014-5793(01)02950-7	http://dx.doi.org/10.1016/S0014-5793(01)02950-7
DOI	10.1016/S0162-0134(03)00249-6	http://dx.doi.org/10.1016/S0162-0134(03)00249-6
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M101772200	http://dx.doi.org/10.1074/jbc.M101772200
DOI	10.1093/dnares/12.2.117	http://dx.doi.org/10.1093/dnares/12.2.117
DOI	10.1101/gr.10.5.703	http://dx.doi.org/10.1101/gr.10.5.703
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF132942	http://www.ebi.ac.uk/ena/data/view/AF132942
EMBL	AF151829	http://www.ebi.ac.uk/ena/data/view/AF151829
EMBL	AJ243649	http://www.ebi.ac.uk/ena/data/view/AJ243649
EMBL	AJ243650	http://www.ebi.ac.uk/ena/data/view/AJ243650
EMBL	AJ271671	http://www.ebi.ac.uk/ena/data/view/AJ271671
EMBL	AK074943	http://www.ebi.ac.uk/ena/data/view/AK074943
EMBL	AK075257	http://www.ebi.ac.uk/ena/data/view/AK075257
EMBL	AK293389	http://www.ebi.ac.uk/ena/data/view/AK293389
EMBL	AL358472	http://www.ebi.ac.uk/ena/data/view/AL358472
EMBL	BC002563	http://www.ebi.ac.uk/ena/data/view/BC002563
EMBL	BC003152	http://www.ebi.ac.uk/ena/data/view/BC003152
EMBL	BC007886	http://www.ebi.ac.uk/ena/data/view/BC007886
EMBL	BC014303	http://www.ebi.ac.uk/ena/data/view/BC014303
EMBL	CH471121	http://www.ebi.ac.uk/ena/data/view/CH471121
EMBL	CH471121	http://www.ebi.ac.uk/ena/data/view/CH471121
EMBL	CH471121	http://www.ebi.ac.uk/ena/data/view/CH471121
EMBL	CH471121	http://www.ebi.ac.uk/ena/data/view/CH471121
EMBL	CH471121	http://www.ebi.ac.uk/ena/data/view/CH471121
Ensembl	ENST00000310483	http://www.ensembl.org/id/ENST00000310483
Ensembl	ENST00000356205	http://www.ensembl.org/id/ENST00000356205
Ensembl	ENST00000368621	http://www.ensembl.org/id/ENST00000368621
Ensembl	ENST00000368623	http://www.ensembl.org/id/ENST00000368623
Ensembl	ENST00000617697	http://www.ensembl.org/id/ENST00000617697
Ensembl	ENST00000621013	http://www.ensembl.org/id/ENST00000621013
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005385
GO_function	GO:0022890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022890
GO_process	GO:0001701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001701
GO_process	GO:0006812	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006812
GO_process	GO:0048701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048701
GO_process	GO:0060173	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060173
GO_process	GO:0071577	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071577
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009790
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC39A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC39A1
GeneID	27173	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27173
GeneTree	ENSGT00530000063242	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063242
HGNC	HGNC:12876	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:12876
HOGENOM	HOG000236331	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236331&db=HOGENOM6
HOVERGEN	HBG015174	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG015174&db=HOVERGEN
HPA	HPA016506	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA016506
InParanoid	Q9NY26	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NY26
IntAct	Q9NY26	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NY26*
InterPro	IPR003689	http://www.ebi.ac.uk/interpro/entry/IPR003689
Jabion	27173	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=27173
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:27173	http://www.genome.jp/dbget-bin/www_bget?hsa:27173
KEGG_Orthology	KO:K14709	http://www.genome.jp/dbget-bin/www_bget?KO:K14709
MIM	604740	http://www.ncbi.nlm.nih.gov/omim/604740
OMA	WEGAGIP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WEGAGIP
OrthoDB	EOG091G0DW2	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0DW2
PSORT	swissprot:S39A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S39A1_HUMAN
PSORT-B	swissprot:S39A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S39A1_HUMAN
PSORT2	swissprot:S39A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S39A1_HUMAN
Pfam	PF02535	http://pfam.xfam.org/family/PF02535
PharmGKB	PA37465	http://www.pharmgkb.org/do/serve?objId=PA37465&objCls=Gene
Phobius	swissprot:S39A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S39A1_HUMAN
PhylomeDB	Q9NY26	http://phylomedb.org/?seqid=Q9NY26
ProteinModelPortal	Q9NY26	http://www.proteinmodelportal.org/query/uniprot/Q9NY26
PubMed	10610721	http://www.ncbi.nlm.nih.gov/pubmed/10610721
PubMed	10810093	http://www.ncbi.nlm.nih.gov/pubmed/10810093
PubMed	11301334	http://www.ncbi.nlm.nih.gov/pubmed/11301334
PubMed	11696349	http://www.ncbi.nlm.nih.gov/pubmed/11696349
PubMed	12888280	http://www.ncbi.nlm.nih.gov/pubmed/12888280
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16303743	http://www.ncbi.nlm.nih.gov/pubmed/16303743
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
Reactome	R-HSA-442380	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442380
RefSeq	NP_001258886	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001258886
RefSeq	NP_001258887	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001258887
RefSeq	NP_001258888	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001258888
RefSeq	NP_001258889	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001258889
RefSeq	NP_001258890	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001258890
RefSeq	NP_055252	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055252
STRING	9606.ENSP00000309710	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000309710&targetmode=cogs
TCDB	2.A.5.3	http://www.tcdb.org/search/result.php?tc=2.A.5.3
UCSC	uc001fdi	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001fdi&org=rat
UniGene	Hs.743291	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.743291
UniGene	Hs.7854	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.7854
UniProtKB	S39A1_HUMAN	http://www.uniprot.org/uniprot/S39A1_HUMAN
UniProtKB-AC	Q9NY26	http://www.uniprot.org/uniprot/Q9NY26
charge	swissprot:S39A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S39A1_HUMAN
eggNOG	ENOG4111GP2	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111GP2
eggNOG	KOG1558	http://eggnogapi.embl.de/nog_data/html/tree/KOG1558
epestfind	swissprot:S39A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S39A1_HUMAN
garnier	swissprot:S39A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S39A1_HUMAN
helixturnhelix	swissprot:S39A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S39A1_HUMAN
hmoment	swissprot:S39A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S39A1_HUMAN
iep	swissprot:S39A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S39A1_HUMAN
inforesidue	swissprot:S39A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S39A1_HUMAN
neXtProt	NX_Q9NY26	http://www.nextprot.org/db/entry/NX_Q9NY26
octanol	swissprot:S39A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S39A1_HUMAN
pepcoil	swissprot:S39A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S39A1_HUMAN
pepdigest	swissprot:S39A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S39A1_HUMAN
pepinfo	swissprot:S39A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S39A1_HUMAN
pepnet	swissprot:S39A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S39A1_HUMAN
pepstats	swissprot:S39A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S39A1_HUMAN
pepwheel	swissprot:S39A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S39A1_HUMAN
pepwindow	swissprot:S39A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S39A1_HUMAN
sigcleave	swissprot:S39A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S39A1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CNNM4_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P4Q7-1; Sequence=Displayed; Name=2; IsoId=Q6P4Q7-2; Sequence=VSP_054271, VSP_054272; Note=No experimental confirmation available.; 
# AltName	CNNM4_HUMAN	Ancient conserved domain-containing protein 4
# AltName	CNNM4_HUMAN	Cyclin-M4
# BioGrid	117711	6
# CCDS	CCDS2024	-. [Q6P4Q7-1]
# ChiTaRS	CNNM4	human
# DISEASE	CNNM4_HUMAN	Jalili syndrome (JALIS) [MIM 217080]  A syndrome characterized by the association of cone-rod dystrophy and amelogenesis imperfecta. {ECO 0000269|PubMed 19200525, ECO 0000269|PubMed 19200527}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000377075	ENSP00000366275; ENSG00000158158. [Q6P4Q7-1]
# FUNCTION	CNNM4_HUMAN	Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function. {ECO 0000250, ECO 0000269|PubMed 19200525, ECO 0000269|PubMed 19200527}. 
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:Ensembl.
# GO_function	GO:0015081	sodium ion transmembrane transporter activity; IEA:Ensembl.
# GO_function	GO:0015095	magnesium ion transmembrane transporter activity; IEA:Ensembl.
# GO_process	GO:0007601	visual perception; IEA:UniProtKB-KW.
# GO_process	GO:0010960	magnesium ion homeostasis; IEA:Ensembl.
# GO_process	GO:0015693	magnesium ion transport; IEA:Ensembl.
# GO_process	GO:0050896	response to stimulus; IEA:UniProtKB-KW.
# GO_process	GO:0070166	enamel mineralization; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# Gene3D	2.60.120.10	-; 2.
# Genevisible	Q6P4Q7	HS
# HGNC	HGNC:105	CNNM4
# InterPro	IPR000595	cNMP-bd_dom
# InterPro	IPR000644	CBS_dom
# InterPro	IPR002550	DUF21
# InterPro	IPR014710	RmlC-like_jellyroll
# InterPro	IPR018490	cNMP-bd-like
# KEGG_Brite	ko02000	Transporters
# KEGG_Disease	H01015	[Developmental disorder] Jalili syndrome
# MIM	217080	phenotype
# MIM	607805	gene
# MISCELLANEOUS	CNNM4_HUMAN	Shares weak sequence similarity with the cyclin family, explaining its name. However, it has no cyclin-like function in vivo. 
# Organism	CNNM4_HUMAN	Homo sapiens (Human)
# Orphanet	1873	Jalili syndrome
# PDB	4IY3	X-ray; 3.60 A; A/B/C/D=359-511
# PROSITE	PS50042	CNMP_BINDING_3
# PROSITE	PS51371	CBS; 2
# Pfam	PF00571	CBS
# Pfam	PF01595	DUF21
# Proteomes	UP000005640	Chromosome 2
# RecName	CNNM4_HUMAN	Metal transporter CNNM4
# RefSeq	NP_064569	NM_020184.3. [Q6P4Q7-1]
# SEQUENCE CAUTION	Sequence=AAF86370.1; Type=Frameshift; Positions=108, 120; Evidence={ECO:0000305}; Sequence=AAY14963.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305}; Sequence=BAB14266.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
# SIMILARITY	Belongs to the ACDP family. {ECO	0000305}. 
# SIMILARITY	Contains 1 DUF21 domain. {ECO	0000305}. 
# SIMILARITY	Contains 2 CBS domains. {ECO:0000255|PROSITE- ProRule	PRU00703}. 
# SUBCELLULAR LOCATION	CNNM4_HUMAN	Cell membrane {ECO 0000269|PubMed 22399287}; Multi-pass membrane protein {ECO 0000269|PubMed 22399287}. 
# SUBUNIT	Interacts with COX11. {ECO:0000269|PubMed	15840172}. 
# SUPFAM	SSF51206	SSF51206; 2
# TCDB	9.A.40.3	the hlyc/corc (hcc) family
# TISSUE SPECIFICITY	Widely expressed. Highly expressed in heart. {ECO:0000269|PubMed	12657465}. 
# UCSC	uc002swx	human. [Q6P4Q7-1]
# eggNOG	COG1253	LUCA
# eggNOG	KOG2118	Eukaryota
BLAST	swissprot:CNNM4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CNNM4_HUMAN
COXPRESdb	26504	http://coxpresdb.jp/data/gene/26504.shtml
CleanEx	HS_CNNM4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CNNM4
DOI	10.1016/S0378-1119(02)01210-6	http://dx.doi.org/10.1016/S0378-1119(02)01210-6
DOI	10.1016/j.ajhg.2009.01.006	http://dx.doi.org/10.1016/j.ajhg.2009.01.006
DOI	10.1016/j.ajhg.2009.01.009	http://dx.doi.org/10.1016/j.ajhg.2009.01.009
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M112.342204	http://dx.doi.org/10.1074/jbc.M112.342204
DOI	10.1093/dnares/7.4.271	http://dx.doi.org/10.1093/dnares/7.4.271
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1186/1744-8069-1-15	http://dx.doi.org/10.1186/1744-8069-1-15
EMBL	AB046812	http://www.ebi.ac.uk/ena/data/view/AB046812
EMBL	AC092636	http://www.ebi.ac.uk/ena/data/view/AC092636
EMBL	AF202777	http://www.ebi.ac.uk/ena/data/view/AF202777
EMBL	AK022833	http://www.ebi.ac.uk/ena/data/view/AK022833
EMBL	AK293915	http://www.ebi.ac.uk/ena/data/view/AK293915
EMBL	BC063295	http://www.ebi.ac.uk/ena/data/view/BC063295
EMBL	FJ619522	http://www.ebi.ac.uk/ena/data/view/FJ619522
EMBL	FJ619523	http://www.ebi.ac.uk/ena/data/view/FJ619523
EMBL	FJ619524	http://www.ebi.ac.uk/ena/data/view/FJ619524
Ensembl	ENST00000377075	http://www.ensembl.org/id/ENST00000377075
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_function	GO:0015081	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015081
GO_function	GO:0015095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015095
GO_process	GO:0007601	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007601
GO_process	GO:0010960	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010960
GO_process	GO:0015693	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015693
GO_process	GO:0050896	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050896
GO_process	GO:0070166	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070166
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
Gene3D	2.60.120.10	http://www.cathdb.info/version/latest/superfamily/2.60.120.10
GeneCards	CNNM4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CNNM4
GeneID	26504	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26504
GeneTree	ENSGT00390000002383	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002383
H-InvDB	HIX0002279	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0002279
H-InvDB	HIX0161875	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0161875
HGNC	HGNC:105	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:105
HOGENOM	HOG000231947	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231947&db=HOGENOM6
HOVERGEN	HBG074775	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG074775&db=HOVERGEN
HPA	HPA017732	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA017732
InParanoid	Q6P4Q7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6P4Q7
IntAct	Q6P4Q7	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q6P4Q7*
InterPro	IPR000595	http://www.ebi.ac.uk/interpro/entry/IPR000595
InterPro	IPR000644	http://www.ebi.ac.uk/interpro/entry/IPR000644
InterPro	IPR002550	http://www.ebi.ac.uk/interpro/entry/IPR002550
InterPro	IPR014710	http://www.ebi.ac.uk/interpro/entry/IPR014710
InterPro	IPR018490	http://www.ebi.ac.uk/interpro/entry/IPR018490
Jabion	26504	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=26504
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Disease	H01015	http://www.genome.jp/dbget-bin/www_bget?H01015
KEGG_Gene	hsa:26504	http://www.genome.jp/dbget-bin/www_bget?hsa:26504
KEGG_Orthology	KO:K16302	http://www.genome.jp/dbget-bin/www_bget?KO:K16302
MIM	217080	http://www.ncbi.nlm.nih.gov/omim/217080
MIM	607805	http://www.ncbi.nlm.nih.gov/omim/607805
OMA	WLKWTDK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WLKWTDK
Orphanet	1873	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1873
OrthoDB	EOG091G02YS	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02YS
PDB	4IY3	http://www.ebi.ac.uk/pdbe-srv/view/entry/4IY3
PDBsum	4IY3	http://www.ebi.ac.uk/pdbsum/4IY3
PROSITE	PS50042	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50042
PROSITE	PS51371	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51371
PSORT	swissprot:CNNM4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CNNM4_HUMAN
PSORT-B	swissprot:CNNM4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CNNM4_HUMAN
PSORT2	swissprot:CNNM4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CNNM4_HUMAN
Pfam	PF00571	http://pfam.xfam.org/family/PF00571
Pfam	PF01595	http://pfam.xfam.org/family/PF01595
PharmGKB	PA26671	http://www.pharmgkb.org/do/serve?objId=PA26671&objCls=Gene
Phobius	swissprot:CNNM4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CNNM4_HUMAN
PhylomeDB	Q6P4Q7	http://phylomedb.org/?seqid=Q6P4Q7
ProteinModelPortal	Q6P4Q7	http://www.proteinmodelportal.org/query/uniprot/Q6P4Q7
PubMed	10997877	http://www.ncbi.nlm.nih.gov/pubmed/10997877
PubMed	12657465	http://www.ncbi.nlm.nih.gov/pubmed/12657465
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	15840172	http://www.ncbi.nlm.nih.gov/pubmed/15840172
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	19200525	http://www.ncbi.nlm.nih.gov/pubmed/19200525
PubMed	19200527	http://www.ncbi.nlm.nih.gov/pubmed/19200527
PubMed	22399287	http://www.ncbi.nlm.nih.gov/pubmed/22399287
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
RefSeq	NP_064569	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_064569
SMR	Q6P4Q7	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q6P4Q7
STRING	9606.ENSP00000366275	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000366275&targetmode=cogs
SUPFAM	SSF51206	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51206
TCDB	9.A.40.3	http://www.tcdb.org/search/result.php?tc=9.A.40.3
UCSC	uc002swx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002swx&org=rat
UniGene	Hs.175043	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.175043
UniProtKB	CNNM4_HUMAN	http://www.uniprot.org/uniprot/CNNM4_HUMAN
UniProtKB-AC	Q6P4Q7	http://www.uniprot.org/uniprot/Q6P4Q7
charge	swissprot:CNNM4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CNNM4_HUMAN
eggNOG	COG1253	http://eggnogapi.embl.de/nog_data/html/tree/COG1253
eggNOG	KOG2118	http://eggnogapi.embl.de/nog_data/html/tree/KOG2118
epestfind	swissprot:CNNM4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CNNM4_HUMAN
garnier	swissprot:CNNM4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CNNM4_HUMAN
helixturnhelix	swissprot:CNNM4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CNNM4_HUMAN
hmoment	swissprot:CNNM4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CNNM4_HUMAN
iep	swissprot:CNNM4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CNNM4_HUMAN
inforesidue	swissprot:CNNM4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CNNM4_HUMAN
neXtProt	NX_Q6P4Q7	http://www.nextprot.org/db/entry/NX_Q6P4Q7
octanol	swissprot:CNNM4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CNNM4_HUMAN
pepcoil	swissprot:CNNM4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CNNM4_HUMAN
pepdigest	swissprot:CNNM4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CNNM4_HUMAN
pepinfo	swissprot:CNNM4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CNNM4_HUMAN
pepnet	swissprot:CNNM4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CNNM4_HUMAN
pepstats	swissprot:CNNM4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CNNM4_HUMAN
pepwheel	swissprot:CNNM4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CNNM4_HUMAN
pepwindow	swissprot:CNNM4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CNNM4_HUMAN
sigcleave	swissprot:CNNM4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CNNM4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TP4AP_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8TEL6-1; Sequence=Displayed; Name=2; IsoId=Q8TEL6-2; Sequence=VSP_003982; Note=No experimental confirmation available.; Name=3; IsoId=Q8TEL6-3; Sequence=VSP_054231; 
# AltName	TP4AP_HUMAN	Protein TAP1
# AltName	TP4AP_HUMAN	TNF-receptor ubiquitous scaffolding/signaling protein
# BioGrid	117569	45
# CCDS	CCDS13246	-. [Q8TEL6-1]
# CCDS	CCDS46591	-. [Q8TEL6-3]
# ChiTaRS	TRPC4AP	human
# Ensembl	ENST00000252015	ENSP00000252015; ENSG00000100991. [Q8TEL6-1]
# Ensembl	ENST00000451813	ENSP00000400614; ENSG00000100991. [Q8TEL6-3]
# FUNCTION	TP4AP_HUMAN	Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1. {ECO 0000269|PubMed 20551172}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex; IDA:UniProtKB.
# GO_function	GO:0005262	calcium channel activity; TAS:Reactome.
# GO_function	GO:0019902	phosphatase binding; IDA:UniProtKB.
# GO_process	GO:0006511	ubiquitin-dependent protein catabolic process; IDA:UniProtKB.
# GO_process	GO:0016567	protein ubiquitination; IDA:UniProtKB.
# GO_process	GO:0070588	calcium ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0009056	catabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q8TEL6	HS
# HGNC	HGNC:16181	TRPC4AP
# INTERACTION	TP4AP_HUMAN	P62136 PPP1CA; NbExp=2; IntAct=EBI-2559060, EBI-357253; 
# IntAct	Q8TEL6	13
# InterPro	IPR016024	ARM-type_fold
# InterPro	IPR022162	DUF3689
# KEGG_Brite	ko04121	Ubiquitin system
# MIM	608430	gene
# Organism	TP4AP_HUMAN	Homo sapiens (Human)
# PATHWAY	TP4AP_HUMAN	Protein modification; protein ubiquitination. 
# PIR	T17263	T17263
# Pfam	PF12463	DUF3689
# Proteomes	UP000005640	Chromosome 20
# Reactome	R-HSA-3295583	TRP channels
# RecName	TP4AP_HUMAN	Short transient receptor potential channel 4-associated protein
# RefSeq	NP_056453	NM_015638.2. [Q8TEL6-1]
# RefSeq	NP_955400	NM_199368.1. [Q8TEL6-3]
# SEQUENCE CAUTION	Sequence=BAB84932.1; Type=Frameshift; Positions=43; Evidence={ECO	0000305};
# SUBUNIT	TP4AP_HUMAN	Constitutively associated with TNFRSF1A. Directly interacts with TRADD, TRAF2, CHUK, IKBKB and IKBKG. Interacts with TRPC1, TRPC4 and TRPC5 (By similarity). Component of the DCX(TRUSS) E3 ubiquitin ligase complex, at least composed of CUL4A, DDB1, TRPC4AP/TRUSS and RBX1. Interacts directly with DDB1. Interacts with MYC. {ECO 0000250|UniProtKB Q9JLV2, ECO 0000269|PubMed 19966799, ECO 0000269|PubMed 20551172}. 
# SUPFAM	SSF48371	SSF48371; 4
# UCSC	uc002xbk	human. [Q8TEL6-1]
# eggNOG	ENOG410IH9D	Eukaryota
# eggNOG	ENOG410ZAXR	LUCA
BLAST	swissprot:TP4AP_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TP4AP_HUMAN
BioCyc	ZFISH:ENSG00000100991-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000100991-MONOMER
COXPRESdb	26133	http://coxpresdb.jp/data/gene/26133.shtml
CleanEx	HS_TRPC4AP	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TRPC4AP
DIP	DIP-42719N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-42719N
DOI	10.1038/414865a	http://dx.doi.org/10.1038/414865a
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/nsmb.1719	http://dx.doi.org/10.1038/nsmb.1719
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1101/gad.1920310	http://dx.doi.org/10.1101/gad.1920310
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AB590540	http://www.ebi.ac.uk/ena/data/view/AB590540
EMBL	AK074106	http://www.ebi.ac.uk/ena/data/view/AK074106
EMBL	AL117480	http://www.ebi.ac.uk/ena/data/view/AL117480
EMBL	AL132825	http://www.ebi.ac.uk/ena/data/view/AL132825
EMBL	BC001323	http://www.ebi.ac.uk/ena/data/view/BC001323
EMBL	BC008836	http://www.ebi.ac.uk/ena/data/view/BC008836
EMBL	BC013144	http://www.ebi.ac.uk/ena/data/view/BC013144
EMBL	CH471077	http://www.ebi.ac.uk/ena/data/view/CH471077
EMBL	CH471077	http://www.ebi.ac.uk/ena/data/view/CH471077
EMBL	CH471077	http://www.ebi.ac.uk/ena/data/view/CH471077
EMBL	CH471077	http://www.ebi.ac.uk/ena/data/view/CH471077
Ensembl	ENST00000252015	http://www.ensembl.org/id/ENST00000252015
Ensembl	ENST00000451813	http://www.ensembl.org/id/ENST00000451813
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0031464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031464
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0019902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019902
GO_process	GO:0006511	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006511
GO_process	GO:0016567	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016567
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0009056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	TRPC4AP	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TRPC4AP
GeneID	26133	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26133
GeneTree	ENSGT00390000018330	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000018330
HGNC	HGNC:16181	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16181
HOGENOM	HOG000231794	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231794&db=HOGENOM6
HOVERGEN	HBG059886	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG059886&db=HOVERGEN
HPA	HPA051197	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA051197
InParanoid	Q8TEL6	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8TEL6
IntAct	Q8TEL6	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8TEL6*
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
InterPro	IPR022162	http://www.ebi.ac.uk/interpro/entry/IPR022162
Jabion	26133	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=26133
KEGG_Brite	ko04121	http://www.genome.jp/dbget-bin/www_bget?ko04121
KEGG_Gene	hsa:26133	http://www.genome.jp/dbget-bin/www_bget?hsa:26133
KEGG_Orthology	KO:K11796	http://www.genome.jp/dbget-bin/www_bget?KO:K11796
MIM	608430	http://www.ncbi.nlm.nih.gov/omim/608430
MINT	MINT-2844857	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-2844857
OMA	QESTFPN	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QESTFPN
OrthoDB	EOG091G02AE	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02AE
PSORT	swissprot:TP4AP_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TP4AP_HUMAN
PSORT-B	swissprot:TP4AP_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TP4AP_HUMAN
PSORT2	swissprot:TP4AP_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TP4AP_HUMAN
Pfam	PF12463	http://pfam.xfam.org/family/PF12463
PharmGKB	PA25730	http://www.pharmgkb.org/do/serve?objId=PA25730&objCls=Gene
Phobius	swissprot:TP4AP_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TP4AP_HUMAN
PhylomeDB	Q8TEL6	http://phylomedb.org/?seqid=Q8TEL6
ProteinModelPortal	Q8TEL6	http://www.proteinmodelportal.org/query/uniprot/Q8TEL6
PubMed	11780052	http://www.ncbi.nlm.nih.gov/pubmed/11780052
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	19966799	http://www.ncbi.nlm.nih.gov/pubmed/19966799
PubMed	20551172	http://www.ncbi.nlm.nih.gov/pubmed/20551172
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
Reactome	R-HSA-3295583	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3295583
RefSeq	NP_056453	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_056453
RefSeq	NP_955400	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_955400
STRING	9606.ENSP00000252015	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000252015&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
UCSC	uc002xbk	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002xbk&org=rat
UniGene	Hs.168073	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.168073
UniProtKB	TP4AP_HUMAN	http://www.uniprot.org/uniprot/TP4AP_HUMAN
UniProtKB-AC	Q8TEL6	http://www.uniprot.org/uniprot/Q8TEL6
charge	swissprot:TP4AP_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TP4AP_HUMAN
eggNOG	ENOG410IH9D	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IH9D
eggNOG	ENOG410ZAXR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZAXR
epestfind	swissprot:TP4AP_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TP4AP_HUMAN
garnier	swissprot:TP4AP_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TP4AP_HUMAN
helixturnhelix	swissprot:TP4AP_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TP4AP_HUMAN
hmoment	swissprot:TP4AP_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TP4AP_HUMAN
iep	swissprot:TP4AP_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TP4AP_HUMAN
inforesidue	swissprot:TP4AP_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TP4AP_HUMAN
neXtProt	NX_Q8TEL6	http://www.nextprot.org/db/entry/NX_Q8TEL6
octanol	swissprot:TP4AP_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TP4AP_HUMAN
pepcoil	swissprot:TP4AP_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TP4AP_HUMAN
pepdigest	swissprot:TP4AP_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TP4AP_HUMAN
pepinfo	swissprot:TP4AP_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TP4AP_HUMAN
pepnet	swissprot:TP4AP_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TP4AP_HUMAN
pepstats	swissprot:TP4AP_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TP4AP_HUMAN
pepwheel	swissprot:TP4AP_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TP4AP_HUMAN
pepwindow	swissprot:TP4AP_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TP4AP_HUMAN
sigcleave	swissprot:TP4AP_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TP4AP_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TUSC3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13454-1; Sequence=Displayed; Name=2; IsoId=Q13454-2; Sequence=VSP_003776; 
# AltName	TUSC3_HUMAN	Magnesium uptake/transporter TUSC3
# AltName	TUSC3_HUMAN	Protein N33
# BioGrid	113701	22
# CCDS	CCDS5993	-. [Q13454-2]
# CCDS	CCDS5994	-. [Q13454-1]
# ChiTaRS	TUSC3	human
# DISEASE	TUSC3_HUMAN	Mental retardation, autosomal recessive 7 (MRT7) [MIM 611093]  A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO 0000269|PubMed 18452889, ECO 0000269|PubMed 18455129}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000382020	ENSP00000371450; ENSG00000104723. [Q13454-2]
# Ensembl	ENST00000503731	ENSP00000424544; ENSG00000104723. [Q13454-1]
# ExpressionAtlas	Q13454	baseline and differential
# FUNCTION	TUSC3_HUMAN	Magnesium transporter (PubMed 19717468). May be involved in N-glycosylation through its association with N-oligosaccharyl transferase (PubMed 24685145). {ECO 0000269|PubMed 19717468, ECO 0000303|PubMed 12887896, ECO 0000303|PubMed 24685145}. 
# GO_component	GO:0005739	mitochondrion; ISS:UniProtKB.
# GO_component	GO:0005789	endoplasmic reticulum membrane; TAS:Reactome.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; NAS:UniProtKB.
# GO_component	GO:0008250	oligosaccharyltransferase complex; IDA:HGNC.
# GO_function	GO:0015095	magnesium ion transmembrane transporter activity; IMP:UniProtKB.
# GO_process	GO:0006487	protein N-linked glycosylation; NAS:UniProtKB.
# GO_process	GO:0015693	magnesium ion transport; IMP:UniProtKB.
# GO_process	GO:0018279	protein N-linked glycosylation via asparagine; ISS:UniProtKB.
# GO_process	GO:0050890	cognition; IMP:UniProtKB.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.30.10	-; 1.
# Genevisible	Q13454	HS
# HGNC	HGNC:30242	TUSC3
# InterPro	IPR012336	Thioredoxin-like_fold
# InterPro	IPR021149	OligosaccharylTrfase_OST3/OST6
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Disease	H00768	[Congenital disorder; Mental retardation] Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
# KEGG_Pathway	ko00510	N-Glycan biosynthesis
# KEGG_Pathway	ko00513	Various types of N-glycan biosynthesis
# KEGG_Pathway	ko04141	Protein processing in endoplasmic reticulum
# MIM	601385	gene
# MIM	611093	phenotype
# Organism	TUSC3_HUMAN	Homo sapiens (Human)
# Orphanet	88616	Autosomal recessive non-syndromic intellectual disability
# PDB	4M8G	X-ray; 2.00 A; A/B=44-194
# PDB	4M90	X-ray; 1.60 A; A=44-194
# PDB	4M91	X-ray; 1.10 A; A=44-194
# PDB	4M92	X-ray; 1.60 A; A=44-194
# PIR	G02297	G02297
# Pfam	PF04756	OST3_OST6
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-446203	Asparagine N-linked glycosylation
# Reactome	R-HSA-5223345	Miscellaneous transport and binding events
# RecName	TUSC3_HUMAN	Tumor suppressor candidate 3
# RefSeq	NP_006756	NM_006765.3. [Q13454-1]
# RefSeq	NP_839952	NM_178234.2. [Q13454-2]
# SIMILARITY	Belongs to the OST3/OST6 family. {ECO	0000305}. 
# SIMILARITY	Contains 1 thioredoxin domain. {ECO	0000305}.
# SUBCELLULAR LOCATION	TUSC3_HUMAN	Endoplasmic reticulum membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUBUNIT	Weakly associates with the oligosaccharyl transferase (OST) complex which contains at least RPN1/ribophorin I, RPN2/ribophorin II, OST48, DAD1, and either STT3A or STT3B. {ECO:0000250, ECO	0000303|PubMed:12887896}. 
# SUPFAM	SSF52833	SSF52833
# TCDB	1.A.76.1	the magnesium transporter1 (magt1) family
# TISSUE SPECIFICITY	Expressed in most non-lymphoid cells and tissues examined, including prostate, lung, liver, colon, heart, kidney and pancreas. {ECO:0000269|PubMed	12887896}. 
# UCSC	uc003wwt	human. [Q13454-1]
# eggNOG	ENOG410XR1F	LUCA
# eggNOG	KOG2603	Eukaryota
BLAST	swissprot:TUSC3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TUSC3_HUMAN
BioCyc	ZFISH:ENSG00000104723-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000104723-MONOMER
COXPRESdb	7991	http://coxpresdb.jp/data/gene/7991.shtml
CleanEx	HS_TUSC3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TUSC3
DOI	10.1006/geno.1996.0322	http://dx.doi.org/10.1006/geno.1996.0322
DOI	10.1016/S1097-2765(03)00243-0	http://dx.doi.org/10.1016/S1097-2765(03)00243-0
DOI	10.1016/j.ajhg.2008.03.018	http://dx.doi.org/10.1016/j.ajhg.2008.03.018
DOI	10.1016/j.ajhg.2008.03.021	http://dx.doi.org/10.1016/j.ajhg.2008.03.021
DOI	10.1016/j.str.2014.02.013	http://dx.doi.org/10.1016/j.str.2014.02.013
DOI	10.1038/nature04406	http://dx.doi.org/10.1038/nature04406
DOI	10.1056/NEJMoa1206524	http://dx.doi.org/10.1056/NEJMoa1206524
DOI	10.1073/pnas.0908332106	http://dx.doi.org/10.1073/pnas.0908332106
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC010656	http://www.ebi.ac.uk/ena/data/view/AC010656
EMBL	AC019292	http://www.ebi.ac.uk/ena/data/view/AC019292
EMBL	AC091559	http://www.ebi.ac.uk/ena/data/view/AC091559
EMBL	AC100850	http://www.ebi.ac.uk/ena/data/view/AC100850
EMBL	BC010370	http://www.ebi.ac.uk/ena/data/view/BC010370
EMBL	BT020002	http://www.ebi.ac.uk/ena/data/view/BT020002
EMBL	CH471080	http://www.ebi.ac.uk/ena/data/view/CH471080
EMBL	CH471080	http://www.ebi.ac.uk/ena/data/view/CH471080
EMBL	U42349	http://www.ebi.ac.uk/ena/data/view/U42349
EMBL	U42350	http://www.ebi.ac.uk/ena/data/view/U42350
EMBL	U42350	http://www.ebi.ac.uk/ena/data/view/U42350
EMBL	U42351	http://www.ebi.ac.uk/ena/data/view/U42351
EMBL	U42351	http://www.ebi.ac.uk/ena/data/view/U42351
EMBL	U42352	http://www.ebi.ac.uk/ena/data/view/U42352
EMBL	U42352	http://www.ebi.ac.uk/ena/data/view/U42352
EMBL	U42354	http://www.ebi.ac.uk/ena/data/view/U42354
EMBL	U42354	http://www.ebi.ac.uk/ena/data/view/U42354
EMBL	U42355	http://www.ebi.ac.uk/ena/data/view/U42355
EMBL	U42355	http://www.ebi.ac.uk/ena/data/view/U42355
EMBL	U42356	http://www.ebi.ac.uk/ena/data/view/U42356
EMBL	U42356	http://www.ebi.ac.uk/ena/data/view/U42356
EMBL	U42357	http://www.ebi.ac.uk/ena/data/view/U42357
EMBL	U42357	http://www.ebi.ac.uk/ena/data/view/U42357
EMBL	U42358	http://www.ebi.ac.uk/ena/data/view/U42358
EMBL	U42358	http://www.ebi.ac.uk/ena/data/view/U42358
EMBL	U42359	http://www.ebi.ac.uk/ena/data/view/U42359
EMBL	U42360	http://www.ebi.ac.uk/ena/data/view/U42360
Ensembl	ENST00000382020	http://www.ensembl.org/id/ENST00000382020
Ensembl	ENST00000503731	http://www.ensembl.org/id/ENST00000503731
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0008250	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008250
GO_function	GO:0015095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015095
GO_process	GO:0006487	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006487
GO_process	GO:0015693	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015693
GO_process	GO:0018279	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018279
GO_process	GO:0050890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050890
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.30.10	http://www.cathdb.info/version/latest/superfamily/3.40.30.10
GeneCards	TUSC3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TUSC3
GeneID	7991	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7991
GeneTree	ENSGT00390000012030	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000012030
HGNC	HGNC:30242	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:30242
HOGENOM	HOG000231301	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231301&db=HOGENOM6
HOVERGEN	HBG002493	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG002493&db=HOVERGEN
HPA	HPA049851	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA049851
HPA	HPA049974	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA049974
InParanoid	Q13454	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q13454
IntAct	Q13454	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q13454*
InterPro	IPR012336	http://www.ebi.ac.uk/interpro/entry/IPR012336
InterPro	IPR021149	http://www.ebi.ac.uk/interpro/entry/IPR021149
Jabion	7991	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7991
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Disease	H00768	http://www.genome.jp/dbget-bin/www_bget?H00768
KEGG_Gene	hsa:7991	http://www.genome.jp/dbget-bin/www_bget?hsa:7991
KEGG_Orthology	KO:K12669	http://www.genome.jp/dbget-bin/www_bget?KO:K12669
KEGG_Pathway	ko00510	http://www.genome.jp/kegg-bin/show_pathway?ko00510
KEGG_Pathway	ko00513	http://www.genome.jp/kegg-bin/show_pathway?ko00513
KEGG_Pathway	ko04141	http://www.genome.jp/kegg-bin/show_pathway?ko04141
MIM	601385	http://www.ncbi.nlm.nih.gov/omim/601385
MIM	611093	http://www.ncbi.nlm.nih.gov/omim/611093
MINT	MINT-1192091	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1192091
OMA	DLIARSW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DLIARSW
Orphanet	88616	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=88616
OrthoDB	EOG091G0ERM	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0ERM
PDB	4M8G	http://www.ebi.ac.uk/pdbe-srv/view/entry/4M8G
PDB	4M90	http://www.ebi.ac.uk/pdbe-srv/view/entry/4M90
PDB	4M91	http://www.ebi.ac.uk/pdbe-srv/view/entry/4M91
PDB	4M92	http://www.ebi.ac.uk/pdbe-srv/view/entry/4M92
PDBsum	4M8G	http://www.ebi.ac.uk/pdbsum/4M8G
PDBsum	4M90	http://www.ebi.ac.uk/pdbsum/4M90
PDBsum	4M91	http://www.ebi.ac.uk/pdbsum/4M91
PDBsum	4M92	http://www.ebi.ac.uk/pdbsum/4M92
PSORT	swissprot:TUSC3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TUSC3_HUMAN
PSORT-B	swissprot:TUSC3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TUSC3_HUMAN
PSORT2	swissprot:TUSC3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TUSC3_HUMAN
Pfam	PF04756	http://pfam.xfam.org/family/PF04756
PharmGKB	PA128394537	http://www.pharmgkb.org/do/serve?objId=PA128394537&objCls=Gene
Phobius	swissprot:TUSC3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TUSC3_HUMAN
PhylomeDB	Q13454	http://phylomedb.org/?seqid=Q13454
ProteinModelPortal	Q13454	http://www.proteinmodelportal.org/query/uniprot/Q13454
PubMed	12887896	http://www.ncbi.nlm.nih.gov/pubmed/12887896
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16421571	http://www.ncbi.nlm.nih.gov/pubmed/16421571
PubMed	18452889	http://www.ncbi.nlm.nih.gov/pubmed/18452889
PubMed	18455129	http://www.ncbi.nlm.nih.gov/pubmed/18455129
PubMed	19717468	http://www.ncbi.nlm.nih.gov/pubmed/19717468
PubMed	23033978	http://www.ncbi.nlm.nih.gov/pubmed/23033978
PubMed	24685145	http://www.ncbi.nlm.nih.gov/pubmed/24685145
PubMed	8661104	http://www.ncbi.nlm.nih.gov/pubmed/8661104
Reactome	R-HSA-446203	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-446203
Reactome	R-HSA-5223345	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5223345
RefSeq	NP_006756	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006756
RefSeq	NP_839952	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_839952
SMR	Q13454	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q13454
STRING	9606.ENSP00000221167	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000221167&targetmode=cogs
SUPFAM	SSF52833	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833
TCDB	1.A.76.1	http://www.tcdb.org/search/result.php?tc=1.A.76.1
UCSC	uc003wwt	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003wwt&org=rat
UniGene	Hs.426324	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.426324
UniGene	Hs.600825	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.600825
UniProtKB	TUSC3_HUMAN	http://www.uniprot.org/uniprot/TUSC3_HUMAN
UniProtKB-AC	Q13454	http://www.uniprot.org/uniprot/Q13454
charge	swissprot:TUSC3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TUSC3_HUMAN
eggNOG	ENOG410XR1F	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XR1F
eggNOG	KOG2603	http://eggnogapi.embl.de/nog_data/html/tree/KOG2603
epestfind	swissprot:TUSC3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TUSC3_HUMAN
garnier	swissprot:TUSC3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TUSC3_HUMAN
helixturnhelix	swissprot:TUSC3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TUSC3_HUMAN
hmoment	swissprot:TUSC3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TUSC3_HUMAN
iep	swissprot:TUSC3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TUSC3_HUMAN
inforesidue	swissprot:TUSC3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TUSC3_HUMAN
neXtProt	NX_Q13454	http://www.nextprot.org/db/entry/NX_Q13454
octanol	swissprot:TUSC3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TUSC3_HUMAN
pepcoil	swissprot:TUSC3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TUSC3_HUMAN
pepdigest	swissprot:TUSC3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TUSC3_HUMAN
pepinfo	swissprot:TUSC3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TUSC3_HUMAN
pepnet	swissprot:TUSC3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TUSC3_HUMAN
pepstats	swissprot:TUSC3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TUSC3_HUMAN
pepwheel	swissprot:TUSC3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TUSC3_HUMAN
pepwindow	swissprot:TUSC3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TUSC3_HUMAN
sigcleave	swissprot:TUSC3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TUSC3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	NCKX4_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8NFF2-1; Sequence=Displayed; Name=2; IsoId=Q8NFF2-2; Sequence=VSP_008369; Name=3; IsoId=Q8NFF2-3; Sequence=VSP_008372; Name=4; IsoId=Q8NFF2-4; Sequence=VSP_008370, VSP_008371; Note=No experimental confirmation available.; 
# AltName	NCKX4_HUMAN	Na(+)/K(+)/Ca(2+)-exchange protein 4
# AltName	NCKX4_HUMAN	Solute carrier family 24 member 4
# CAUTION	It is uncertain whether Met-1 or Met-18 is the initiator. {ECO	0000305}. 
# CCDS	CCDS45155	-. [Q8NFF2-3]
# CCDS	CCDS45156	-. [Q8NFF2-2]
# CCDS	CCDS9903	-. [Q8NFF2-1]
# DISEASE	NCKX4_HUMAN	Amelogenesis imperfecta, hypomaturation type, 2A5 (AI2A5) [MIM 615887]  A defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel. {ECO 0000269|PubMed 23375655, ECO 0000269|PubMed 24621671}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000393265	ENSP00000376948; ENSG00000140090. [Q8NFF2-2]
# Ensembl	ENST00000531433	ENSP00000433302; ENSG00000140090. [Q8NFF2-3]
# Ensembl	ENST00000532405	ENSP00000431840; ENSG00000140090. [Q8NFF2-1]
# ExpressionAtlas	Q8NFF2	baseline and differential
# FUNCTION	NCKX4_HUMAN	Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis (By similarity). {ECO 0000250|UniProtKB Q8CGQ8}. 
# GO_component	GO:0005737	cytoplasm; ISS:UniProtKB.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016020	membrane; ISS:UniProtKB.
# GO_function	GO:0005262	calcium channel activity; IBA:GO_Central.
# GO_function	GO:0005509	calcium ion binding; IBA:GO_Central.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_function	GO:0030955	potassium ion binding; IBA:GO_Central.
# GO_function	GO:0031402	sodium ion binding; IBA:GO_Central.
# GO_function	NCKX4_HUMAN	GO 0008273 calcium, potassium sodium antiporter activity; IBA GO_Central.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006874	cellular calcium ion homeostasis; IBA:GO_Central.
# GO_process	GO:0007608	sensory perception of smell; ISS:UniProtKB.
# GO_process	GO:0050896	response to stimulus; IEA:UniProtKB-KW.
# GO_process	GO:0097186	amelogenesis; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048646	anatomical structure formation involved in morphogenesis
# GOslim_process	GO:0050877	neurological system process
# Genevisible	Q8NFF2	HS
# HGNC	HGNC:10978	SLC24A4
# InterPro	IPR004481	K/Na/Ca-exchanger
# InterPro	IPR004837	NaCa_Exmemb
# InterPro	IPR030232	SLC24A4
# KEGG_Brite	ko02001	Solute carrier family
# MIM	210750	phenotype
# MIM	609840	gene
# MIM	615887	phenotype
# Organism	NCKX4_HUMAN	Homo sapiens (Human)
# Orphanet	100032	Hypocalcified amelogenesis imperfecta
# Orphanet	100033	Hypomaturation amelogenesis imperfecta
# PANTHER	PTHR10846	PTHR10846
# PANTHER	PTHR10846:SF21	PTHR10846:SF21
# POLYMORPHISM	Genetic variants in SLC24A4 define the skin/hair/eye pigmentation variation locus 6 (SHEP6) [MIM:210750]. Hair, eye and skin pigmentation are among the most visible examples of human phenotypic variation, with a broad normal range that is subject to substantial geographic stratification. In the case of skin, individuals tend to have lighter pigmentation with increasing distance from the equator. By contrast, the majority of variation in human eye and hair color is found among individuals of European ancestry, with most other human populations fixed for brown eyes and black hair. {ECO	0000269|PubMed:17952075}. 
# Pfam	PF01699	Na_Ca_ex; 2
# Proteomes	UP000005640	Chromosome 14
# Reactome	R-HSA-425561	Sodium/Calcium exchangers
# RecName	NCKX4_HUMAN	Sodium/potassium/calcium exchanger 4
# RefSeq	NP_705932	NM_153646.3. [Q8NFF2-1]
# RefSeq	NP_705933	NM_153647.3. [Q8NFF2-3]
# RefSeq	NP_705934	NM_153648.3. [Q8NFF2-2]
# RefSeq	XP_011534743	XM_011536441.2
# RefSeq	XP_011534744	XM_011536442.2
# SEQUENCE CAUTION	NCKX4_HUMAN	Sequence=AAH69653.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=AAM76070.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=AAM76071.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=BAC04715.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO 0000305}; Sequence=CAD38903.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305};
# SIMILARITY	Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	NCKX4_HUMAN	Cytoplasm {ECO 0000250|UniProtKB Q8CGQ8}. Cell membrane {ECO 0000250|UniProtKB Q8CGQ8}; Multi-pass membrane protein {ECO 0000250|UniProtKB Q8CGQ8}. 
# TCDB	2.A.19.4:the ca(2+)	cation antiporter (caca) family
# TIGRFAMs	TIGR00367	TIGR00367
# TISSUE SPECIFICITY	NCKX4_HUMAN	Expressed abundantly in all regions of the brain, aorta, lung and thymus. Expressed at lower levels in the stomach and intestine. 
# UCSC	uc001yai	human. [Q8NFF2-1]
# eggNOG	ENOG410Y9YY	LUCA
# eggNOG	KOG1307	Eukaryota
BLAST	swissprot:NCKX4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NCKX4_HUMAN
COXPRESdb	123041	http://coxpresdb.jp/data/gene/123041.shtml
CleanEx	HS_SLC24A4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC24A4
DOI	10.1016/j.ajhg.2013.01.003	http://dx.doi.org/10.1016/j.ajhg.2013.01.003
DOI	10.1038/nature01348	http://dx.doi.org/10.1038/nature01348
DOI	10.1038/ng.2007.13	http://dx.doi.org/10.1038/ng.2007.13
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M210011200	http://dx.doi.org/10.1074/jbc.M210011200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1177/0022034514527971	http://dx.doi.org/10.1177/0022034514527971
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AF520704	http://www.ebi.ac.uk/ena/data/view/AF520704
EMBL	AF520705	http://www.ebi.ac.uk/ena/data/view/AF520705
EMBL	AF520706	http://www.ebi.ac.uk/ena/data/view/AF520706
EMBL	AK096171	http://www.ebi.ac.uk/ena/data/view/AK096171
EMBL	AK295059	http://www.ebi.ac.uk/ena/data/view/AK295059
EMBL	AL118559	http://www.ebi.ac.uk/ena/data/view/AL118559
EMBL	AL834225	http://www.ebi.ac.uk/ena/data/view/AL834225
EMBL	BC069653	http://www.ebi.ac.uk/ena/data/view/BC069653
EMBL	CH471061	http://www.ebi.ac.uk/ena/data/view/CH471061
Ensembl	ENST00000393265	http://www.ensembl.org/id/ENST00000393265
Ensembl	ENST00000531433	http://www.ensembl.org/id/ENST00000531433
Ensembl	ENST00000532405	http://www.ensembl.org/id/ENST00000532405
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0008273	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008273
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_function	GO:0030955	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030955
GO_function	GO:0031402	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031402
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874
GO_process	GO:0007608	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007608
GO_process	GO:0050896	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050896
GO_process	GO:0097186	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097186
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048646	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048646
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	SLC24A4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC24A4
GeneID	123041	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=123041
GeneTree	ENSGT00760000119209	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119209
HGNC	HGNC:10978	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10978
HOVERGEN	HBG054881	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054881&db=HOVERGEN
InParanoid	Q8NFF2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8NFF2
InterPro	IPR004481	http://www.ebi.ac.uk/interpro/entry/IPR004481
InterPro	IPR004837	http://www.ebi.ac.uk/interpro/entry/IPR004837
InterPro	IPR030232	http://www.ebi.ac.uk/interpro/entry/IPR030232
Jabion	123041	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=123041
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:123041	http://www.genome.jp/dbget-bin/www_bget?hsa:123041
KEGG_Orthology	KO:K13752	http://www.genome.jp/dbget-bin/www_bget?KO:K13752
MIM	210750	http://www.ncbi.nlm.nih.gov/omim/210750
MIM	609840	http://www.ncbi.nlm.nih.gov/omim/609840
MIM	615887	http://www.ncbi.nlm.nih.gov/omim/615887
OMA	SPFSMPE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SPFSMPE
Orphanet	100032	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=100032
Orphanet	100033	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=100033
OrthoDB	EOG091G0M5C	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0M5C
PANTHER	PTHR10846	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10846
PANTHER	PTHR10846:SF21	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10846:SF21
PSORT	swissprot:NCKX4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NCKX4_HUMAN
PSORT-B	swissprot:NCKX4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NCKX4_HUMAN
PSORT2	swissprot:NCKX4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NCKX4_HUMAN
Pfam	PF01699	http://pfam.xfam.org/family/PF01699
PharmGKB	PA35854	http://www.pharmgkb.org/do/serve?objId=PA35854&objCls=Gene
Phobius	swissprot:NCKX4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NCKX4_HUMAN
PhylomeDB	Q8NFF2	http://phylomedb.org/?seqid=Q8NFF2
ProteinModelPortal	Q8NFF2	http://www.proteinmodelportal.org/query/uniprot/Q8NFF2
PubMed	12379639	http://www.ncbi.nlm.nih.gov/pubmed/12379639
PubMed	12508121	http://www.ncbi.nlm.nih.gov/pubmed/12508121
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17952075	http://www.ncbi.nlm.nih.gov/pubmed/17952075
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	23375655	http://www.ncbi.nlm.nih.gov/pubmed/23375655
PubMed	24621671	http://www.ncbi.nlm.nih.gov/pubmed/24621671
Reactome	R-HSA-425561	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425561
RefSeq	NP_705932	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_705932
RefSeq	NP_705933	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_705933
RefSeq	NP_705934	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_705934
RefSeq	XP_011534743	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011534743
RefSeq	XP_011534744	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011534744
STRING	9606.ENSP00000431840	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000431840&targetmode=cogs
TCDB	2.A.19.4	http://www.tcdb.org/search/result.php?tc=2.A.19.4
TIGRFAMs	TIGR00367	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00367
UCSC	uc001yai	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001yai&org=rat
UniGene	Hs.385530	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.385530
UniProtKB	NCKX4_HUMAN	http://www.uniprot.org/uniprot/NCKX4_HUMAN
UniProtKB-AC	Q8NFF2	http://www.uniprot.org/uniprot/Q8NFF2
charge	swissprot:NCKX4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NCKX4_HUMAN
eggNOG	ENOG410Y9YY	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y9YY
eggNOG	KOG1307	http://eggnogapi.embl.de/nog_data/html/tree/KOG1307
epestfind	swissprot:NCKX4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NCKX4_HUMAN
garnier	swissprot:NCKX4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NCKX4_HUMAN
helixturnhelix	swissprot:NCKX4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NCKX4_HUMAN
hmoment	swissprot:NCKX4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NCKX4_HUMAN
iep	swissprot:NCKX4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NCKX4_HUMAN
inforesidue	swissprot:NCKX4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NCKX4_HUMAN
neXtProt	NX_Q8NFF2	http://www.nextprot.org/db/entry/NX_Q8NFF2
octanol	swissprot:NCKX4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NCKX4_HUMAN
pepcoil	swissprot:NCKX4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NCKX4_HUMAN
pepdigest	swissprot:NCKX4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NCKX4_HUMAN
pepinfo	swissprot:NCKX4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NCKX4_HUMAN
pepnet	swissprot:NCKX4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NCKX4_HUMAN
pepstats	swissprot:NCKX4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NCKX4_HUMAN
pepwheel	swissprot:NCKX4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NCKX4_HUMAN
pepwindow	swissprot:NCKX4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NCKX4_HUMAN
sigcleave	swissprot:NCKX4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NCKX4_HUMAN
## Database	ID	URL or Descriptions
# AltName	ACATN_HUMAN	Solute carrier family 33 member 1
# BioGrid	114632	58
# ChiTaRS	SLC33A1	human
# DISEASE	ACATN_HUMAN	Congenital cataracts, hearing loss, and neurodegeneration (CCHLND) [MIM 614482]  An autosomal recessive disorder characterized by congenital cataracts, severe psychomotor retardation, and hearing loss associated with decreased serum ceruloplasmin and copper. Brain MRI shows cerebral and cerebellar atrophy and hypomyelination. {ECO 0000269|PubMed 22243965}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ACATN_HUMAN	Spastic paraplegia 42, autosomal dominant (SPG42) [MIM 612539]  A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. {ECO 0000269|PubMed 19061983, ECO 0000269|PubMed 25402622}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000359479	ENSP00000352456; ENSG00000169359
# Ensembl	ENST00000392845	ENSP00000376587; ENSG00000169359
# ExpressionAtlas	O00400	baseline and differential
# FUNCTION	ACATN_HUMAN	Probable acetyl-CoA transporter necessary for O- acetylation of gangliosides (PubMed 9096318). Negatively regulates BMP signaling (PubMed 25402622). {ECO 0000269|PubMed 25402622, ECO 0000269|PubMed 9096318}. 
# GO_component	GO:0000139	Golgi membrane; TAS:Reactome.
# GO_component	GO:0005789	endoplasmic reticulum membrane; TAS:ProtInc.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_function	ACATN_HUMAN	GO 0015295 solute proton symporter activity; IBA GO_Central.
# GO_function	GO:0008521	acetyl-CoA transporter activity; TAS:Reactome.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0030509	BMP signaling pathway; IDA:UniProtKB.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GO_process	GO:0060395	SMAD protein signal transduction; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	O00400	HS
# HGNC	HGNC:95	SLC33A1
# IntAct	O00400	58
# InterPro	IPR004752	AmpG_permease/AT-1
# InterPro	IPR020846	MFS_dom
# InterPro	IPR024371	Acetyl-CoA_trnpstr_1
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Brite	ko02000	 Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H00266	[Nervous system disease; Muscular disease] Hereditary spastic paraplegia (SPG)
# KEGG_Pathway	ko00604	Glycosphingolipid biosynthesis - ganglio series
# MIM	603690	gene
# MIM	612539	phenotype
# MIM	614482	phenotype
# Organism	ACATN_HUMAN	Homo sapiens (Human)
# Orphanet	171863	Autosomal dominant spastic paraplegia type 42
# Orphanet	300313	Congenital cataract-hearing loss-severe developmental delay syndrome
# Pfam	PF13000	Acatn; 2
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-425397	Transport of vitamins, nucleosides, and related molecules
# RecName	ACATN_HUMAN	Acetyl-coenzyme A transporter 1
# RefSeq	NP_001177921	NM_001190992.1
# RefSeq	NP_004724	NM_004733.3
# SIMILARITY	Belongs to the SLC33A transporter family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	ACATN_HUMAN	Endoplasmic reticulum membrane {ECO 0000305|PubMed 9096318}; Multi-pass membrane protein {ECO 0000305|PubMed 9096318}. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.1.25	the major facilitator superfamily (mfs)
# TIGRFAMs	TIGR00901	2A0125
# TISSUE SPECIFICITY	Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. With strongest signals in pancreas. {ECO:0000269|PubMed	9096318}. 
# UCSC	uc003fan	human
# WEB RESOURCE	ACATN_HUMAN	Name=Mendelian genes solute carrier family 33 (acetyl-CoA transporter), member 1 (SLC33A1); Note=Leiden Open Variation Database (LOVD); URL="http //www.lovd.nl/SLC33A1";
# eggNOG	COG0477	LUCA
# eggNOG	KOG3574	Eukaryota
BLAST	swissprot:ACATN_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ACATN_HUMAN
BioCyc	ZFISH:ENSG00000169359-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000169359-MONOMER
COXPRESdb	9197	http://coxpresdb.jp/data/gene/9197.shtml
CleanEx	HS_SLC33A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC33A1
DOI	10.1002/humu.22732	http://dx.doi.org/10.1002/humu.22732
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.ajhg.2008.11.003	http://dx.doi.org/10.1016/j.ajhg.2008.11.003
DOI	10.1016/j.ajhg.2011.11.030	http://dx.doi.org/10.1016/j.ajhg.2011.11.030
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.94.7.2897	http://dx.doi.org/10.1073/pnas.94.7.2897
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
EMBL	AK312268	http://www.ebi.ac.uk/ena/data/view/AK312268
EMBL	BC014416	http://www.ebi.ac.uk/ena/data/view/BC014416
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
EMBL	D88152	http://www.ebi.ac.uk/ena/data/view/D88152
Ensembl	ENST00000359479	http://www.ensembl.org/id/ENST00000359479
Ensembl	ENST00000392845	http://www.ensembl.org/id/ENST00000392845
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0008521	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008521
GO_function	GO:0015295	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015295
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0030509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030509
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GO_process	GO:0060395	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060395
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC33A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC33A1
GeneID	9197	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9197
GeneTree	ENSGT00730000111115	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00730000111115
HGNC	HGNC:95	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:95
HOGENOM	HOG000194770	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000194770&db=HOGENOM6
HOVERGEN	HBG052723	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052723&db=HOVERGEN
HPA	HPA042430	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042430
HPA	HPA060345	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA060345
InParanoid	O00400	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O00400
IntAct	O00400	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O00400*
InterPro	IPR004752	http://www.ebi.ac.uk/interpro/entry/IPR004752
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
InterPro	IPR024371	http://www.ebi.ac.uk/interpro/entry/IPR024371
Jabion	9197	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9197
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00266	http://www.genome.jp/dbget-bin/www_bget?H00266
KEGG_Gene	hsa:9197	http://www.genome.jp/dbget-bin/www_bget?hsa:9197
KEGG_Orthology	KO:K03372	http://www.genome.jp/dbget-bin/www_bget?KO:K03372
KEGG_Pathway	ko00604	http://www.genome.jp/kegg-bin/show_pathway?ko00604
MIM	603690	http://www.ncbi.nlm.nih.gov/omim/603690
MIM	612539	http://www.ncbi.nlm.nih.gov/omim/612539
MIM	614482	http://www.ncbi.nlm.nih.gov/omim/614482
OMA	LWFWGIT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LWFWGIT
Orphanet	171863	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=171863
Orphanet	300313	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=300313
OrthoDB	EOG091G06Y7	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G06Y7
PSORT	swissprot:ACATN_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ACATN_HUMAN
PSORT-B	swissprot:ACATN_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ACATN_HUMAN
PSORT2	swissprot:ACATN_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ACATN_HUMAN
Pfam	PF13000	http://pfam.xfam.org/family/PF13000
PharmGKB	PA24432	http://www.pharmgkb.org/do/serve?objId=PA24432&objCls=Gene
Phobius	swissprot:ACATN_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ACATN_HUMAN
PhylomeDB	O00400	http://phylomedb.org/?seqid=O00400
ProteinModelPortal	O00400	http://www.proteinmodelportal.org/query/uniprot/O00400
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	19061983	http://www.ncbi.nlm.nih.gov/pubmed/19061983
PubMed	22243965	http://www.ncbi.nlm.nih.gov/pubmed/22243965
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	25402622	http://www.ncbi.nlm.nih.gov/pubmed/25402622
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	9096318	http://www.ncbi.nlm.nih.gov/pubmed/9096318
Reactome	R-HSA-425397	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425397
RefSeq	NP_001177921	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001177921
RefSeq	NP_004724	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004724
STRING	9606.ENSP00000352456	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000352456&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.25	http://www.tcdb.org/search/result.php?tc=2.A.1.25
TIGRFAMs	TIGR00901	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00901
UCSC	uc003fan	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003fan&org=rat
UniGene	Hs.478031	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.478031
UniProtKB	ACATN_HUMAN	http://www.uniprot.org/uniprot/ACATN_HUMAN
UniProtKB-AC	O00400	http://www.uniprot.org/uniprot/O00400
charge	swissprot:ACATN_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ACATN_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG3574	http://eggnogapi.embl.de/nog_data/html/tree/KOG3574
epestfind	swissprot:ACATN_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ACATN_HUMAN
garnier	swissprot:ACATN_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ACATN_HUMAN
helixturnhelix	swissprot:ACATN_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACATN_HUMAN
hmoment	swissprot:ACATN_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ACATN_HUMAN
iep	swissprot:ACATN_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ACATN_HUMAN
inforesidue	swissprot:ACATN_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ACATN_HUMAN
neXtProt	NX_O00400	http://www.nextprot.org/db/entry/NX_O00400
octanol	swissprot:ACATN_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ACATN_HUMAN
pepcoil	swissprot:ACATN_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ACATN_HUMAN
pepdigest	swissprot:ACATN_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ACATN_HUMAN
pepinfo	swissprot:ACATN_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ACATN_HUMAN
pepnet	swissprot:ACATN_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ACATN_HUMAN
pepstats	swissprot:ACATN_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ACATN_HUMAN
pepwheel	swissprot:ACATN_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ACATN_HUMAN
pepwindow	swissprot:ACATN_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ACATN_HUMAN
sigcleave	swissprot:ACATN_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ACATN_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AP1S1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P61966-1, Q00382-1; Sequence=Displayed; Name=2; IsoId=P61966-2, Q00382-2; Sequence=VSP_000171; 
# AltName	AP1S1_HUMAN	Adaptor protein complex AP-1 subunit sigma-1A
# AltName	AP1S1_HUMAN	Adaptor-related protein complex 1 subunit sigma-1A
# AltName	AP1S1_HUMAN	Clathrin assembly protein complex 1 sigma-1A small chain
# AltName	AP1S1_HUMAN	Clathrin coat assembly protein AP19
# AltName	AP1S1_HUMAN	Golgi adaptor HA1/AP1 adaptin sigma-1A subunit
# AltName	AP1S1_HUMAN	HA1 19 kDa subunit
# AltName	AP1S1_HUMAN	Sigma 1a subunit of AP-1 clathrin
# AltName	AP1S1_HUMAN	Sigma-adaptin 1A
# AltName	AP1S1_HUMAN	Sigma1A-adaptin
# BioGrid	107588	19
# ChiTaRS	AP1S1	human
# DISEASE	AP1S1_HUMAN	Mental retardation, enteropathy, deafness, peripheral neuropathy, ichthyosis, and keratoderma (MEDNIK) [MIM 609313]  A disorder characterized by erythematous skin lesions and hyperkeratosis, severe psychomotor retardation, peripheral neuropathy, sensorineural hearing loss, together with elevated very-long-chain fatty acids and severe congenital diarrhea. {ECO 0000269|PubMed 19057675}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000337619	ENSP00000336666; ENSG00000106367. [P61966-1]
# Ensembl	ENST00000443943	ENSP00000410780; ENSG00000106367. [P61966-1]
# ExpressionAtlas	P61966	baseline and differential
# FUNCTION	AP1S1_HUMAN	Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. {ECO 0000269|PubMed 9733768}. 
# GO_component	GO:0000139	Golgi membrane; TAS:Reactome.
# GO_component	GO:0005765	lysosomal membrane; TAS:Reactome.
# GO_component	GO:0005794	Golgi apparatus; IDA:HPA.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0005905	clathrin-coated pit; IEA:UniProtKB-SubCell.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0030121	AP-1 adaptor complex; TAS:UniProtKB.
# GO_component	GO:0030659	cytoplasmic vesicle membrane; TAS:Reactome.
# GO_component	GO:0030669	clathrin-coated endocytic vesicle membrane; TAS:Reactome.
# GO_component	GO:0032588	trans-Golgi network membrane; TAS:Reactome.
# GO_component	GO:0043195	terminal bouton; IEA:Ensembl.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0008565	protein transporter activity; IEA:InterPro.
# GO_process	GO:0006886	intracellular protein transport; IEA:InterPro.
# GO_process	GO:0006898	receptor-mediated endocytosis; TAS:UniProtKB.
# GO_process	GO:0009615	response to virus; IEP:UniProtKB.
# GO_process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
# GO_process	GO:0042147	retrograde transport, endosome to Golgi; IEA:Ensembl.
# GO_process	GO:0050690	regulation of defense response to virus by virus; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# Genevisible	P61966	HS
# HGNC	HGNC:559	AP1S1
# INDUCTION	Up-regulated in response to enterovirus 71 (EV71) infection. {ECO:0000269|PubMed	16548883}. 
# IntAct	P61966	5
# InterPro	IPR000804	Clathrin_sm-chain_CS
# InterPro	IPR011012	Longin-like_dom
# InterPro	IPR016635	AP_complex_ssu
# InterPro	IPR022775	AP_mu_sigma_su
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Pathway	ko04142	Lysosome
# MIM	603531	gene
# MIM	609313	phenotype
# Organism	AP1S1_HUMAN	Homo sapiens (Human)
# Orphanet	171851	MEDNIK syndrome
# PANTHER	PTHR11753	PTHR11753
# PDB	4P6Z	X-ray; 3.00 A; S=1-158
# PIRSF	PIRSF015588	AP_complex_sigma
# PROSITE	PS00989	CLAT_ADAPTOR_S
# Pfam	PF01217	Clat_adaptor_s
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-164940	Nef mediated downregulation of MHC class I complex cell surface expression
# Reactome	R-HSA-2132295	MHC class II antigen presentation
# Reactome	R-HSA-432720	Lysosome Vesicle Biogenesis
# Reactome	R-HSA-432722	Golgi Associated Vesicle Biogenesis
# RecName	AP1S1_HUMAN	AP-1 complex subunit sigma-1A
# RefSeq	NP_001274	NM_001283.3. [P61966-1]
# SEQUENCE CAUTION	Sequence=AAD45829.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the adaptor complexes small subunit family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	AP1S1_HUMAN	Golgi apparatus {ECO 0000269|PubMed 9733768}. Cytoplasmic vesicle membrane {ECO 0000269|PubMed 9733768}; Peripheral membrane protein {ECO 0000269|PubMed 9733768}; Cytoplasmic side {ECO 0000269|PubMed 9733768}. Membrane, clathrin-coated pit {ECO 0000269|PubMed 9733768}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. 
# SUBUNIT	AP1S1_HUMAN	Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta- type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). 
# SUPFAM	SSF64356	SSF64356
# TISSUE SPECIFICITY	Widely expressed. {ECO:0000269|PubMed	9733768}. 
# UCSC	uc003uxv	human
# eggNOG	COG5030	LUCA
# eggNOG	KOG0934	Eukaryota
BLAST	swissprot:AP1S1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AP1S1_HUMAN
BioCyc	ZFISH:ENSG00000106367-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000106367-MONOMER
COXPRESdb	1174	http://coxpresdb.jp/data/gene/1174.shtml
CleanEx	HS_AP1S1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AP1S1
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.273.38.24693	http://dx.doi.org/10.1074/jbc.273.38.24693
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1462-5822.2005.00644.x	http://dx.doi.org/10.1111/j.1462-5822.2005.00644.x
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1371/journal.pgen.1000296	http://dx.doi.org/10.1371/journal.pgen.1000296
EMBL	AB015319	http://www.ebi.ac.uk/ena/data/view/AB015319
EMBL	AC004876	http://www.ebi.ac.uk/ena/data/view/AC004876
EMBL	AK312151	http://www.ebi.ac.uk/ena/data/view/AK312151
EMBL	BC003561	http://www.ebi.ac.uk/ena/data/view/BC003561
EMBL	BT006779	http://www.ebi.ac.uk/ena/data/view/BT006779
EMBL	CH471197	http://www.ebi.ac.uk/ena/data/view/CH471197
Ensembl	ENST00000337619	http://www.ensembl.org/id/ENST00000337619
Ensembl	ENST00000443943	http://www.ensembl.org/id/ENST00000443943
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005905	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005905
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0030121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030121
GO_component	GO:0030659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030659
GO_component	GO:0030669	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030669
GO_component	GO:0032588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032588
GO_component	GO:0043195	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043195
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0006886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006886
GO_process	GO:0006898	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006898
GO_process	GO:0009615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009615
GO_process	GO:0019886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019886
GO_process	GO:0042147	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042147
GO_process	GO:0050690	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050690
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
GeneCards	AP1S1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=AP1S1
GeneID	1174	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1174
GeneTree	ENSGT00530000062839	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062839
HGNC	HGNC:559	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:559
HOVERGEN	HBG050517	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050517&db=HOVERGEN
HPA	HPA060945	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA060945
InParanoid	P61966	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P61966
IntAct	P61966	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P61966*
InterPro	IPR000804	http://www.ebi.ac.uk/interpro/entry/IPR000804
InterPro	IPR011012	http://www.ebi.ac.uk/interpro/entry/IPR011012
InterPro	IPR016635	http://www.ebi.ac.uk/interpro/entry/IPR016635
InterPro	IPR022775	http://www.ebi.ac.uk/interpro/entry/IPR022775
Jabion	1174	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1174
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Gene	hsa:1174	http://www.genome.jp/dbget-bin/www_bget?hsa:1174
KEGG_Orthology	KO:K12394	http://www.genome.jp/dbget-bin/www_bget?KO:K12394
KEGG_Pathway	ko04142	http://www.genome.jp/kegg-bin/show_pathway?ko04142
MIM	603531	http://www.ncbi.nlm.nih.gov/omim/603531
MIM	609313	http://www.ncbi.nlm.nih.gov/omim/609313
MINT	MINT-5006039	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5006039
Orphanet	171851	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=171851
PANTHER	PTHR11753	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11753
PDB	4P6Z	http://www.ebi.ac.uk/pdbe-srv/view/entry/4P6Z
PDBsum	4P6Z	http://www.ebi.ac.uk/pdbsum/4P6Z
PROSITE	PS00989	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00989
PSORT	swissprot:AP1S1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AP1S1_HUMAN
PSORT-B	swissprot:AP1S1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AP1S1_HUMAN
PSORT2	swissprot:AP1S1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AP1S1_HUMAN
Pfam	PF01217	http://pfam.xfam.org/family/PF01217
PharmGKB	PA24850	http://www.pharmgkb.org/do/serve?objId=PA24850&objCls=Gene
Phobius	swissprot:AP1S1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AP1S1_HUMAN
PhylomeDB	P61966	http://phylomedb.org/?seqid=P61966
ProteinModelPortal	P61966	http://www.proteinmodelportal.org/query/uniprot/P61966
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16548883	http://www.ncbi.nlm.nih.gov/pubmed/16548883
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	19057675	http://www.ncbi.nlm.nih.gov/pubmed/19057675
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	9733768	http://www.ncbi.nlm.nih.gov/pubmed/9733768
Reactome	R-HSA-164940	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-164940
Reactome	R-HSA-2132295	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2132295
Reactome	R-HSA-432720	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432720
Reactome	R-HSA-432722	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432722
RefSeq	NP_001274	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001274
SMR	P61966	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P61966
STRING	9606.ENSP00000336666	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000336666&targetmode=cogs
SUPFAM	SSF64356	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF64356
UCSC	uc003uxv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003uxv&org=rat
UniGene	Hs.489365	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.489365
UniProtKB	AP1S1_HUMAN	http://www.uniprot.org/uniprot/AP1S1_HUMAN
UniProtKB-AC	P61966	http://www.uniprot.org/uniprot/P61966
charge	swissprot:AP1S1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AP1S1_HUMAN
eggNOG	COG5030	http://eggnogapi.embl.de/nog_data/html/tree/COG5030
eggNOG	KOG0934	http://eggnogapi.embl.de/nog_data/html/tree/KOG0934
epestfind	swissprot:AP1S1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AP1S1_HUMAN
garnier	swissprot:AP1S1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AP1S1_HUMAN
helixturnhelix	swissprot:AP1S1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AP1S1_HUMAN
hmoment	swissprot:AP1S1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AP1S1_HUMAN
iep	swissprot:AP1S1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AP1S1_HUMAN
inforesidue	swissprot:AP1S1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AP1S1_HUMAN
neXtProt	NX_P61966	http://www.nextprot.org/db/entry/NX_P61966
octanol	swissprot:AP1S1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AP1S1_HUMAN
pepcoil	swissprot:AP1S1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AP1S1_HUMAN
pepdigest	swissprot:AP1S1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AP1S1_HUMAN
pepinfo	swissprot:AP1S1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AP1S1_HUMAN
pepnet	swissprot:AP1S1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AP1S1_HUMAN
pepstats	swissprot:AP1S1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AP1S1_HUMAN
pepwheel	swissprot:AP1S1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AP1S1_HUMAN
pepwindow	swissprot:AP1S1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AP1S1_HUMAN
sigcleave	swissprot:AP1S1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AP1S1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	JPH3_HUMAN	Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q8WXH2-1; Sequence=Displayed; Name=2; IsoId=Q8WXH2-2; Sequence=VSP_002787, VSP_002788; 
# AltName	JPH3_HUMAN	Junctophilin type 3
# AltName	JPH3_HUMAN	Trinucleotide repeat-containing gene 22 protein
# BioGrid	121492	3
# CCDS	CCDS10962	-. [Q8WXH2-1]
# ChiTaRS	JPH3	human
# DISEASE	JPH3_HUMAN	Huntington disease-like 2 (HDL2) [MIM 606438]  Huntington disease (HD) is a neurodegenerative disorder resulting primarily from the loss of medium spiny projection neurons in the striatum, especially in the caudate nucleus, and, to a lesser extent, atrophy of mesencephalic and cortical structures. The typical clinical picture of HD combines familial adult onset chorea and subcortical dementia that usually begin during the fourth decade of life. {ECO 0000269|PubMed 11914418, ECO 0000269|PubMed 14557581}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	JPH3_HUMAN	The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids. {ECO 0000250}. 
# Ensembl	ENST00000284262	ENSP00000284262; ENSG00000154118. [Q8WXH2-1]
# FUNCTION	JPH3_HUMAN	Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory. 
# GO_component	GO:0005886	plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0014701	junctional sarcoplasmic reticulum membrane; TAS:BHF-UCL.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0030314	junctional membrane complex; IEA:Ensembl.
# GO_function	GO:0015278	calcium-release channel activity; IEA:Ensembl.
# GO_process	GO:0007612	learning; IEA:Ensembl.
# GO_process	GO:0007613	memory; IEA:Ensembl.
# GO_process	GO:0035640	exploration behavior; IEA:Ensembl.
# GO_process	GO:0040011	locomotion; IEA:Ensembl.
# GO_process	GO:0048168	regulation of neuronal synaptic plasticity; IEA:Ensembl.
# GO_process	GO:0050885	neuromuscular process controlling balance; IEA:Ensembl.
# GO_process	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity; TAS:BHF-UCL.
# GO_process	GO:0060402	calcium ion transport into cytosol; TAS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0040011	locomotion
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0050877	neurological system process
# Genevisible	Q8WXH2	HS
# HGNC	HGNC:14203	JPH3
# IntAct	Q8WXH2	2
# InterPro	IPR003409	MORN
# InterPro	IPR017191	Junctophilin
# KEGG_Disease	H00832	[Nervous system disease] Pantothenate kinase associated neurodegeneration (PKAN)
# KEGG_Disease	H01243	[Neurodegenerative disease] Huntington's disease-like syndrome
# MIM	605268	gene
# MIM	606438	phenotype
# Organism	JPH3_HUMAN	Homo sapiens (Human)
# Orphanet	98934	Huntington disease-like 2
# PIRSF	PIRSF037387	Junctophilin
# POLYMORPHISM	JPH3_HUMAN	Isoform 2 length of the poly-Ala region is variable (6 to 27 CTG/CAG triplets) in the normal population and may be expanded (41 to 58 CTG/CAG triplets) in patients suffering from Huntington disease-like type 2. 
# Pfam	PF02493	MORN; 8
# Proteomes	UP000005640	Chromosome 16
# RecName	JPH3_HUMAN	Junctophilin-3
# RefSeq	NP_065706	NM_020655.3. [Q8WXH2-1]
# SIMILARITY	Belongs to the junctophilin family. {ECO	0000305}. 
# SIMILARITY	Contains 8 MORN repeats. {ECO	0000305}.
# SMART	SM00698	MORN; 7
# SUBCELLULAR LOCATION	JPH3_HUMAN	Cell membrane {ECO 0000250}; Peripheral membrane protein {ECO 0000250}. Endoplasmic reticulum membrane {ECO 0000250}; Single-pass type IV membrane protein {ECO 0000250}. Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane (By similarity). {ECO 0000250}. 
# TISSUE SPECIFICITY	Specifically expressed in brain. {ECO:0000269|PubMed	10891348}. 
# UCSC	uc002fkd	human. [Q8WXH2-1]
# eggNOG	COG4642	LUCA
# eggNOG	KOG0231	Eukaryota
BLAST	swissprot:JPH3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:JPH3_HUMAN
BioCyc	ZFISH:ENSG00000154118-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000154118-MONOMER
COXPRESdb	57338	http://coxpresdb.jp/data/gene/57338.shtml
CleanEx	HS_JPH3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_JPH3
DOI	10.1006/bbrc.2000.3011	http://dx.doi.org/10.1006/bbrc.2000.3011
DOI	10.1038/ng760	http://dx.doi.org/10.1038/ng760
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1212/01.WNL.0000085866.68470.6D	http://dx.doi.org/10.1212/01.WNL.0000085866.68470.6D
DOI	10.1212/WNL.58.6.965	http://dx.doi.org/10.1212/WNL.58.6.965
EMBL	AB042636	http://www.ebi.ac.uk/ena/data/view/AB042636
EMBL	AB042640	http://www.ebi.ac.uk/ena/data/view/AB042640
EMBL	AF429315	http://www.ebi.ac.uk/ena/data/view/AF429315
EMBL	BC036533	http://www.ebi.ac.uk/ena/data/view/BC036533
EMBL	BE042890	http://www.ebi.ac.uk/ena/data/view/BE042890
EMBL	CH471114	http://www.ebi.ac.uk/ena/data/view/CH471114
EMBL	CH471114	http://www.ebi.ac.uk/ena/data/view/CH471114
Ensembl	ENST00000284262	http://www.ensembl.org/id/ENST00000284262
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0014701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014701
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030314	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030314
GO_function	GO:0015278	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015278
GO_process	GO:0007612	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007612
GO_process	GO:0007613	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007613
GO_process	GO:0035640	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035640
GO_process	GO:0040011	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011
GO_process	GO:0048168	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048168
GO_process	GO:0050885	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050885
GO_process	GO:0060314	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060314
GO_process	GO:0060402	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060402
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0040011	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	JPH3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=JPH3
GeneID	57338	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57338
GeneTree	ENSGT00730000110639	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00730000110639
H-InvDB	HIX0013325	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0013325
HGNC	HGNC:14203	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14203
HOGENOM	HOG000264244	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264244&db=HOGENOM6
HOVERGEN	HBG031648	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG031648&db=HOVERGEN
InParanoid	Q8WXH2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8WXH2
IntAct	Q8WXH2	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8WXH2*
InterPro	IPR003409	http://www.ebi.ac.uk/interpro/entry/IPR003409
InterPro	IPR017191	http://www.ebi.ac.uk/interpro/entry/IPR017191
Jabion	57338	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=57338
KEGG_Disease	H00832	http://www.genome.jp/dbget-bin/www_bget?H00832
KEGG_Disease	H01243	http://www.genome.jp/dbget-bin/www_bget?H01243
KEGG_Gene	hsa:57338	http://www.genome.jp/dbget-bin/www_bget?hsa:57338
MIM	605268	http://www.ncbi.nlm.nih.gov/omim/605268
MIM	606438	http://www.ncbi.nlm.nih.gov/omim/606438
MINT	MINT-1208946	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1208946
OMA	HPQKRRY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HPQKRRY
Orphanet	98934	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98934
OrthoDB	EOG091G03WX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G03WX
PSORT	swissprot:JPH3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:JPH3_HUMAN
PSORT-B	swissprot:JPH3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:JPH3_HUMAN
PSORT2	swissprot:JPH3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:JPH3_HUMAN
Pfam	PF02493	http://pfam.xfam.org/family/PF02493
PharmGKB	PA30000	http://www.pharmgkb.org/do/serve?objId=PA30000&objCls=Gene
Phobius	swissprot:JPH3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:JPH3_HUMAN
PhylomeDB	Q8WXH2	http://phylomedb.org/?seqid=Q8WXH2
ProteinModelPortal	Q8WXH2	http://www.proteinmodelportal.org/query/uniprot/Q8WXH2
PubMed	10891348	http://www.ncbi.nlm.nih.gov/pubmed/10891348
PubMed	11694876	http://www.ncbi.nlm.nih.gov/pubmed/11694876
PubMed	11914418	http://www.ncbi.nlm.nih.gov/pubmed/11914418
PubMed	14557581	http://www.ncbi.nlm.nih.gov/pubmed/14557581
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
RefSeq	NP_065706	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_065706
SMART	SM00698	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00698
SMR	Q8WXH2	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8WXH2
STRING	9606.ENSP00000284262	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000284262&targetmode=cogs
UCSC	uc002fkd	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002fkd&org=rat
UniGene	Hs.592068	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.592068
UniGene	Hs.733790	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.733790
UniProtKB	JPH3_HUMAN	http://www.uniprot.org/uniprot/JPH3_HUMAN
UniProtKB-AC	Q8WXH2	http://www.uniprot.org/uniprot/Q8WXH2
charge	swissprot:JPH3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:JPH3_HUMAN
eggNOG	COG4642	http://eggnogapi.embl.de/nog_data/html/tree/COG4642
eggNOG	KOG0231	http://eggnogapi.embl.de/nog_data/html/tree/KOG0231
epestfind	swissprot:JPH3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:JPH3_HUMAN
garnier	swissprot:JPH3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:JPH3_HUMAN
helixturnhelix	swissprot:JPH3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:JPH3_HUMAN
hmoment	swissprot:JPH3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:JPH3_HUMAN
iep	swissprot:JPH3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:JPH3_HUMAN
inforesidue	swissprot:JPH3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:JPH3_HUMAN
neXtProt	NX_Q8WXH2	http://www.nextprot.org/db/entry/NX_Q8WXH2
octanol	swissprot:JPH3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:JPH3_HUMAN
pepcoil	swissprot:JPH3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:JPH3_HUMAN
pepdigest	swissprot:JPH3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:JPH3_HUMAN
pepinfo	swissprot:JPH3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:JPH3_HUMAN
pepnet	swissprot:JPH3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:JPH3_HUMAN
pepstats	swissprot:JPH3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:JPH3_HUMAN
pepwheel	swissprot:JPH3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:JPH3_HUMAN
pepwindow	swissprot:JPH3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:JPH3_HUMAN
sigcleave	swissprot:JPH3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:JPH3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	P2RX6_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O15547-1; Sequence=Displayed; Name=2; IsoId=O15547-2; Sequence=VSP_044799; Note=No experimental confirmation available.; 
# AltName	P2RX6_HUMAN	ATP receptor
# AltName	P2RX6_HUMAN	P2XM
# AltName	P2RX6_HUMAN	Purinergic receptor
# AltName	P2RX6_HUMAN	Purinergic receptor P2X-like 1
# BioGrid	114575	4
# CAUTION	It is uncertain whether Met-1 or Met-11 is the initiator. {ECO	0000305}. 
# CCDS	CCDS13788	-. [O15547-1]
# CCDS	CCDS54504	-. [O15547-2]
# Ensembl	ENST00000401443	ENSP00000385309; ENSG00000099957. [O15547-2]
# Ensembl	ENST00000413302	ENSP00000416193; ENSG00000099957. [O15547-1]
# ExpressionAtlas	O15547	baseline and differential
# FUNCTION	P2RX6_HUMAN	Receptor for ATP that acts as a ligand-gated ion channel. {ECO 0000250}. 
# GO_component	GO:0005639	integral component of nuclear inner membrane; IBA:GO_Central.
# GO_component	GO:0005737	cytoplasm; IDA:BHF-UCL.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0030054	cell junction; IDA:BHF-UCL.
# GO_function	GO:0001614	purinergic nucleotide receptor activity; NAS:BHF-UCL.
# GO_function	GO:0004888	transmembrane signaling receptor activity; TAS:ProtInc.
# GO_function	GO:0004931	extracellular ATP-gated cation channel activity; NAS:BHF-UCL.
# GO_function	GO:0005524	ATP binding; NAS:BHF-UCL.
# GO_function	GO:0015267	channel activity; TAS:ProtInc.
# GO_function	GO:0042802	identical protein binding; IPI:BHF-UCL.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006936	muscle contraction; TAS:ProtInc.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0007596	blood coagulation; TAS:Reactome.
# GO_process	GO:0033198	response to ATP; IEA:InterPro.
# GO_process	GO:0051260	protein homooligomerization; IPI:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# Gene3D	2.60.490.10	-; 1.
# Genevisible	O15547	HS
# HGNC	HGNC:8538	P2RX6
# InterPro	IPR001429	P2X_purnocptor
# InterPro	IPR003049	P2X6_purnocptor
# InterPro	IPR027309	P2X_extracellular_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# MIM	608077	gene
# Organism	P2RX6_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10125	PTHR10125
# PIRSF	PIRSF005713	P2X_purinoceptor
# PRINTS	PR01307	P2XRECEPTOR
# PRINTS	PR01313	P2X6RECEPTOR
# PROSITE	PS01212	P2X_RECEPTOR
# PTM	P2RX6_HUMAN	N-glycosylated. {ECO 0000269|PubMed 15657042}. 
# Pfam	PF00864	P2X_receptor
# Proteomes	UP000005640	Chromosome 22
# Reactome	R-HSA-139853	Elevation of cytosolic Ca2+ levels
# Reactome	R-HSA-418346	Platelet homeostasis
# RecName	P2RX6_HUMAN	P2X purinoceptor 6
# RefSeq	NP_001153026	NM_001159554.1. [O15547-2]
# RefSeq	NP_005437	NM_005446.3. [O15547-1]
# SEQUENCE CAUTION	P2RX6_HUMAN	Sequence=AAF13303.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=AAF13303.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO 0000305}; Sequence=AAH33488.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=AAI09210.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=BAA22046.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=BAA22047.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; 
# SIMILARITY	Belongs to the P2X receptor family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	P2RX6_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Unlike most P2XRs, P2RX6 does not seem to form homotrimers or heterotrimers. {ECO:0000269|PubMed	15657042}. 
# TIGRFAMs	TIGR00863	P2X
# TISSUE SPECIFICITY	P2RX6_HUMAN	Expressed predominantly in skeletal muscle. 
# UCSC	uc002ztz	human. [O15547-1]
# WEB RESOURCE	P2RX6_HUMAN	Name=Wikipedia; Note=P2X receptor entry; URL="https //en.wikipedia.org/wiki/P2X_receptor";
# eggNOG	ENOG410IFJF	Eukaryota
# eggNOG	ENOG410XR0C	LUCA
BLAST	swissprot:P2RX6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:P2RX6_HUMAN
BioCyc	ZFISH:ENSG00000099957-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000099957-MONOMER
COXPRESdb	9127	http://coxpresdb.jp/data/gene/9127.shtml
CleanEx	HS_P2RX6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_P2RX6
DOI	10.1002/1615-9861(200206)2:6<642::AID-PROT642>3.0.CO	http://dx.doi.org/10.1002/1615-9861(200206)2:6<642::AID-PROT642>3.0.CO
DOI	10.1038/990031	http://dx.doi.org/10.1038/990031
DOI	10.1074/jbc.M412265200	http://dx.doi.org/10.1074/jbc.M412265200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/gb-2004-5-10-r84	http://dx.doi.org/10.1186/gb-2004-5-10-r84
EMBL	AB002058	http://www.ebi.ac.uk/ena/data/view/AB002058
EMBL	AB002059	http://www.ebi.ac.uk/ena/data/view/AB002059
EMBL	AC002472	http://www.ebi.ac.uk/ena/data/view/AC002472
EMBL	AF065385	http://www.ebi.ac.uk/ena/data/view/AF065385
EMBL	BC033488	http://www.ebi.ac.uk/ena/data/view/BC033488
EMBL	BC109209	http://www.ebi.ac.uk/ena/data/view/BC109209
EMBL	CR456535	http://www.ebi.ac.uk/ena/data/view/CR456535
Ensembl	ENST00000401443	http://www.ensembl.org/id/ENST00000401443
Ensembl	ENST00000413302	http://www.ensembl.org/id/ENST00000413302
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005639	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005639
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_function	GO:0001614	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001614
GO_function	GO:0004888	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004888
GO_function	GO:0004931	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004931
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0015267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015267
GO_function	GO:0042802	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006936	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006936
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007596	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007596
GO_process	GO:0033198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033198
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	2.60.490.10	http://www.cathdb.info/version/latest/superfamily/2.60.490.10
GeneCards	P2RX6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=P2RX6
GeneID	9127	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9127
GeneTree	ENSGT00390000016028	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000016028
HGNC	HGNC:8538	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:8538
HOGENOM	HOG000232042	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000232042&db=HOGENOM6
HOVERGEN	HBG053086	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053086&db=HOVERGEN
HPA	HPA028776	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA028776
HPA	HPA028777	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA028777
InParanoid	O15547	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O15547
IntAct	O15547	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O15547*
InterPro	IPR001429	http://www.ebi.ac.uk/interpro/entry/IPR001429
InterPro	IPR003049	http://www.ebi.ac.uk/interpro/entry/IPR003049
InterPro	IPR027309	http://www.ebi.ac.uk/interpro/entry/IPR027309
Jabion	9127	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9127
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:9127	http://www.genome.jp/dbget-bin/www_bget?hsa:9127
KEGG_Orthology	KO:K05221	http://www.genome.jp/dbget-bin/www_bget?KO:K05221
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
MIM	608077	http://www.ncbi.nlm.nih.gov/omim/608077
OMA	VHWDCDL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VHWDCDL
OrthoDB	EOG091G0A2U	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0A2U
PANTHER	PTHR10125	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10125
PRINTS	PR01307	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01307
PRINTS	PR01313	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01313
PROSITE	PS01212	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01212
PSORT	swissprot:P2RX6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:P2RX6_HUMAN
PSORT-B	swissprot:P2RX6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:P2RX6_HUMAN
PSORT2	swissprot:P2RX6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:P2RX6_HUMAN
Pfam	PF00864	http://pfam.xfam.org/family/PF00864
PharmGKB	PA162398523	http://www.pharmgkb.org/do/serve?objId=PA162398523&objCls=Gene
Phobius	swissprot:P2RX6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:P2RX6_HUMAN
PhylomeDB	O15547	http://phylomedb.org/?seqid=O15547
ProteinModelPortal	O15547	http://www.proteinmodelportal.org/query/uniprot/O15547
PubMed	10591208	http://www.ncbi.nlm.nih.gov/pubmed/10591208
PubMed	12112843	http://www.ncbi.nlm.nih.gov/pubmed/12112843
PubMed	15461802	http://www.ncbi.nlm.nih.gov/pubmed/15461802
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15657042	http://www.ncbi.nlm.nih.gov/pubmed/15657042
PubMed	9242461	http://www.ncbi.nlm.nih.gov/pubmed/9242461
Reactome	R-HSA-139853	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-139853
Reactome	R-HSA-418346	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418346
RefSeq	NP_001153026	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001153026
RefSeq	NP_005437	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005437
SMR	O15547	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O15547
STRING	9606.ENSP00000416193	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000416193&targetmode=cogs
TIGRFAMs	TIGR00863	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00863
UCSC	uc002ztz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ztz&org=rat
UniGene	Hs.113275	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.113275
UniProtKB	P2RX6_HUMAN	http://www.uniprot.org/uniprot/P2RX6_HUMAN
UniProtKB-AC	O15547	http://www.uniprot.org/uniprot/O15547
charge	swissprot:P2RX6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:P2RX6_HUMAN
eggNOG	ENOG410IFJF	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IFJF
eggNOG	ENOG410XR0C	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XR0C
epestfind	swissprot:P2RX6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:P2RX6_HUMAN
garnier	swissprot:P2RX6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:P2RX6_HUMAN
helixturnhelix	swissprot:P2RX6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:P2RX6_HUMAN
hmoment	swissprot:P2RX6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:P2RX6_HUMAN
iep	swissprot:P2RX6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:P2RX6_HUMAN
inforesidue	swissprot:P2RX6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:P2RX6_HUMAN
neXtProt	NX_O15547	http://www.nextprot.org/db/entry/NX_O15547
octanol	swissprot:P2RX6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:P2RX6_HUMAN
pepcoil	swissprot:P2RX6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:P2RX6_HUMAN
pepdigest	swissprot:P2RX6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:P2RX6_HUMAN
pepinfo	swissprot:P2RX6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:P2RX6_HUMAN
pepnet	swissprot:P2RX6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:P2RX6_HUMAN
pepstats	swissprot:P2RX6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:P2RX6_HUMAN
pepwheel	swissprot:P2RX6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:P2RX6_HUMAN
pepwindow	swissprot:P2RX6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:P2RX6_HUMAN
sigcleave	swissprot:P2RX6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:P2RX6_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S6A16_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9GZN6-1; Sequence=Displayed; Name=2; IsoId=Q9GZN6-2; Sequence=VSP_056317; Note=No experimental confirmation available.; 
# AltName	S6A16_HUMAN	Solute carrier family 6 member 16
# CCDS	CCDS42590	-. [Q9GZN6-1]
# Ensembl	ENST00000335875	ENSP00000338627; ENSG00000063127. [Q9GZN6-1]
# Ensembl	ENST00000454748	ENSP00000404022; ENSG00000063127. [Q9GZN6-2]
# ExpressionAtlas	Q9GZN6	baseline and differential
# GO_component	GO:0005622	intracellular; NAS:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0005326	neurotransmitter transporter activity; NAS:UniProtKB.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; IBA:GO_Central.
# GO_function	S6A16_HUMAN	GO 0005328 neurotransmitter sodium symporter activity; IEA InterPro.
# GO_process	GO:0006836	neurotransmitter transport; NAS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005622	intracellular
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q9GZN6	HS
# HGNC	HGNC:13622	SLC6A16
# InterPro	IPR000175	Na/ntran_symport
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Brite	ko04040	 Ion channels
# MIM	607972	gene
# Organism	S6A16_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11616	PTHR11616; 2
# PRINTS	PR00176	NANEUSMPORT
# PROSITE	PS00610	NA_NEUROTRAN_SYMP_1
# PROSITE	PS00754	NA_NEUROTRAN_SYMP_2
# PROSITE	PS50267	NA_NEUROTRAN_SYMP_3
# Pfam	PF00209	SNF
# Proteomes	UP000005640	Chromosome 19
# RecName	S6A16_HUMAN	Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5
# RefSeq	NP_054756	NM_014037.2. [Q9GZN6-1]
# RefSeq	XP_005258877	XM_005258820.2. [Q9GZN6-1]
# RefSeq	XP_006723231	XM_006723168.3. [Q9GZN6-1]
# SIMILARITY	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A16 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	S6A16_HUMAN	Membrane; Multi-pass membrane protein. 
# TCDB	2.A.22.6:the neurotransmitter	sodium symporter (nss) family
# TISSUE SPECIFICITY	S6A16_HUMAN	Highly expressed in peripheral tissues, particularly in testis, pancreas, and prostate. 
# UCSC	uc002pmz	human. [Q9GZN6-1]
# eggNOG	COG0733	LUCA
# eggNOG	KOG3659	Eukaryota
BLAST	swissprot:S6A16_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S6A16_HUMAN
BioCyc	ZFISH:ENSG00000063127-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000063127-MONOMER
COXPRESdb	28968	http://coxpresdb.jp/data/gene/28968.shtml
CleanEx	HS_SLC6A16	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC6A16
DOI	10.1006/geno.2000.6387	http://dx.doi.org/10.1006/geno.2000.6387
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DOI	10.1038/nature09639	http://dx.doi.org/10.1038/nature09639
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1101/gr.GR1547R	http://dx.doi.org/10.1101/gr.GR1547R
EMBL	AC011450	http://www.ebi.ac.uk/ena/data/view/AC011450
EMBL	AF151977	http://www.ebi.ac.uk/ena/data/view/AF151977
EMBL	AF265578	http://www.ebi.ac.uk/ena/data/view/AF265578
EMBL	AL136856	http://www.ebi.ac.uk/ena/data/view/AL136856
EMBL	BC034948	http://www.ebi.ac.uk/ena/data/view/BC034948
Ensembl	ENST00000335875	http://www.ensembl.org/id/ENST00000335875
Ensembl	ENST00000454748	http://www.ensembl.org/id/ENST00000454748
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005326	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005326
GO_function	GO:0005328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005328
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_process	GO:0006836	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006836
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC6A16	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC6A16
GeneID	28968	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=28968
GeneTree	ENSGT00760000119044	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119044
HGNC	HGNC:13622	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13622
HOGENOM	HOG000116406	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116406&db=HOGENOM6
HOVERGEN	HBG098140	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG098140&db=HOVERGEN
InParanoid	Q9GZN6	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9GZN6
InterPro	IPR000175	http://www.ebi.ac.uk/interpro/entry/IPR000175
Jabion	28968	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=28968
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:28968	http://www.genome.jp/dbget-bin/www_bget?hsa:28968
KEGG_Orthology	KO:K05048	http://www.genome.jp/dbget-bin/www_bget?KO:K05048
MIM	607972	http://www.ncbi.nlm.nih.gov/omim/607972
OMA	FFTRPSG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FFTRPSG
OrthoDB	EOG091G05DI	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05DI
PANTHER	PTHR11616	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11616
PRINTS	PR00176	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00176
PROSITE	PS00610	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00610
PROSITE	PS00754	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00754
PROSITE	PS50267	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50267
PSORT	swissprot:S6A16_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S6A16_HUMAN
PSORT-B	swissprot:S6A16_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S6A16_HUMAN
PSORT2	swissprot:S6A16_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S6A16_HUMAN
Pfam	PF00209	http://pfam.xfam.org/family/PF00209
PharmGKB	PA37800	http://www.pharmgkb.org/do/serve?objId=PA37800&objCls=Gene
Phobius	swissprot:S6A16_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S6A16_HUMAN
PhylomeDB	Q9GZN6	http://phylomedb.org/?seqid=Q9GZN6
ProteinModelPortal	Q9GZN6	http://www.proteinmodelportal.org/query/uniprot/Q9GZN6
PubMed	11112352	http://www.ncbi.nlm.nih.gov/pubmed/11112352
PubMed	11230166	http://www.ncbi.nlm.nih.gov/pubmed/11230166
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21248752	http://www.ncbi.nlm.nih.gov/pubmed/21248752
RefSeq	NP_054756	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_054756
RefSeq	XP_005258877	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005258877
RefSeq	XP_006723231	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006723231
STRING	9606.ENSP00000338627	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000338627&targetmode=cogs
TCDB	2.A.22.6	http://www.tcdb.org/search/result.php?tc=2.A.22.6
UCSC	uc002pmz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002pmz&org=rat
UniGene	Hs.130949	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.130949
UniProtKB	S6A16_HUMAN	http://www.uniprot.org/uniprot/S6A16_HUMAN
UniProtKB-AC	Q9GZN6	http://www.uniprot.org/uniprot/Q9GZN6
charge	swissprot:S6A16_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S6A16_HUMAN
eggNOG	COG0733	http://eggnogapi.embl.de/nog_data/html/tree/COG0733
eggNOG	KOG3659	http://eggnogapi.embl.de/nog_data/html/tree/KOG3659
epestfind	swissprot:S6A16_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S6A16_HUMAN
garnier	swissprot:S6A16_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S6A16_HUMAN
helixturnhelix	swissprot:S6A16_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S6A16_HUMAN
hmoment	swissprot:S6A16_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S6A16_HUMAN
iep	swissprot:S6A16_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S6A16_HUMAN
inforesidue	swissprot:S6A16_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S6A16_HUMAN
neXtProt	NX_Q9GZN6	http://www.nextprot.org/db/entry/NX_Q9GZN6
octanol	swissprot:S6A16_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S6A16_HUMAN
pepcoil	swissprot:S6A16_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S6A16_HUMAN
pepdigest	swissprot:S6A16_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S6A16_HUMAN
pepinfo	swissprot:S6A16_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S6A16_HUMAN
pepnet	swissprot:S6A16_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S6A16_HUMAN
pepstats	swissprot:S6A16_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S6A16_HUMAN
pepwheel	swissprot:S6A16_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S6A16_HUMAN
pepwindow	swissprot:S6A16_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S6A16_HUMAN
sigcleave	swissprot:S6A16_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S6A16_HUMAN
## Database	ID	URL or Descriptions
# AltName	MIP_HUMAN	Aquaporin-0
# AltName	MIP_HUMAN	MIP26
# BioGrid	110430	5
# CDD	cd00333	MIP
# DISEASE	MIP_HUMAN	Cataract 15, multiple types (CTRCT15) [MIM 615274]  An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. CTRCT15 includes polymorphic, progressive punctate lamellar, cortical, anterior and posterior polar, nonprogressive lamellar with sutural opacities, embryonic nuclear, and pulverulent cortical, among others. {ECO 0000269|PubMed 10802646, ECO 0000269|PubMed 11001937, ECO 0000269|PubMed 16564824, ECO 0000269|PubMed 17893667, ECO 0000269|PubMed 17960133, ECO 0000269|PubMed 20361015, ECO 0000269|PubMed 21245956, ECO 0000269|PubMed 23116563, ECO 0000269|PubMed 24120416, ECO 0000269|PubMed 25946197}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	MIP_HUMAN	Aquaporins contain two tandem repeats each containing two membrane-spanning helices and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). Each tandem repeat contains a loop and a short helix that enter and leave the lipid bilayer on the same side (By similarity). {ECO 0000250}. 
# Ensembl	ENST00000257979	ENSP00000257979; ENSG00000135517
# FUNCTION	MIP_HUMAN	Water channel (PubMed 24120416). Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (PubMed 24120416). {ECO 0000250|UniProtKB Q6J8I9, ECO 0000269|PubMed 24120416}. 
# GO_component	GO:0005783	endoplasmic reticulum; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; ISS:UniProtKB.
# GO_component	GO:0005921	gap junction; IEA:UniProtKB-SubCell.
# GO_component	GO:0016324	apical plasma membrane; IBA:GO_Central.
# GO_function	GO:0005212	structural constituent of eye lens; IEA:UniProtKB-KW.
# GO_function	GO:0005215	transporter activity; TAS:ProtInc.
# GO_function	GO:0005243	gap junction channel activity; IDA:UniProtKB.
# GO_function	GO:0005516	calmodulin binding; ISS:UniProtKB.
# GO_function	GO:0015250	water channel activity; IDA:UniProtKB.
# GO_function	GO:0015254	glycerol channel activity; IBA:GO_Central.
# GO_process	GO:0002088	lens development in camera-type eye; IEA:Ensembl.
# GO_process	GO:0006833	water transport; ISS:UniProtKB.
# GO_process	GO:0007601	visual perception; IEA:UniProtKB-KW.
# GO_process	GO:0009992	cellular water homeostasis; IBA:GO_Central.
# GO_process	GO:0034220	ion transmembrane transport; IBA:GO_Central.
# GO_process	GO:0045785	positive regulation of cell adhesion; IDA:UniProtKB.
# GO_process	GO:0050896	response to stimulus; IEA:UniProtKB-KW.
# GO_process	GO:0051289	protein homotetramerization; IDA:UniProtKB.
# GO_process	GO:1990349	gap junction-mediated intercellular transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0005198	structural molecule activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.1080.10	-; 1.
# Genevisible	P30301	HS
# HGNC	HGNC:7103	MIP
# IntAct	P30301	4
# InterPro	IPR000425	MIP
# InterPro	IPR022357	MIP_CS
# InterPro	IPR023271	Aquaporin-like
# KEGG_Brite	ko04040	Ion channels
# KEGG_Disease	H01202	[Eye disease] Cataract
# MIM	154050	gene
# MIM	615274	phenotype
# Organism	MIP_HUMAN	Homo sapiens (Human)
# Orphanet	98985	Cataract with Y-shaped suture opacities
# Orphanet	98989	Cerulean cataract
# Orphanet	98991	Nuclear cataract
# Orphanet	98994	Total congenital cataract
# Orphanet	98995	Zonular cataract
# PANTHER	PTHR19139	PTHR19139
# PIR	A55279	A55279
# PRINTS	PR00783	MINTRINSICP
# PROSITE	PS00221	MIP
# PTM	MIP_HUMAN	Subject to partial proteolytic cleavage in the eye lens core. Partial proteolysis promotes interactions between tetramers from adjoining membranes (By similarity). {ECO 0000250}. 
# Pfam	PF00230	MIP
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-432047	Passive transport by Aquaporins
# RecName	MIP_HUMAN	Lens fiber major intrinsic protein
# RefSeq	NP_036196	NM_012064.3
# SIMILARITY	Belongs to the MIP/aquaporin (TC 1.A.8) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	MIP_HUMAN	Cell membrane {ECO 0000269|PubMed 23116563, ECO 0000269|PubMed 24120416, ECO 0000269|PubMed 25946197}; Multi- pass membrane protein {ECO 0000250|UniProtKB Q6J8I9}. Cell junction, gap junction {ECO 0000269|PubMed 24120416}. 
# SUBUNIT	MIP_HUMAN	Homotetramer (PubMed 24120416). Homooctamer formed by head-to-head interaction between homotetramers from adjoining membranes. Interacts with CALM; one CALM molecule interacts with the cytoplasmic domains of two aquaporins, leading to channel closure (By similarity). {ECO 0000250|UniProtKB P06624, ECO 0000269|PubMed 24120416}. 
# SUPFAM	SSF81338	SSF81338
# TIGRFAMs	TIGR00861	MIP
# TISSUE SPECIFICITY	MIP_HUMAN	Major component of lens fiber gap junctions. 
# UCSC	uc001slh	human
# eggNOG	COG0580	LUCA
# eggNOG	KOG0223	Eukaryota
BLAST	swissprot:MIP_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MIP_HUMAN
BioCyc	ZFISH:ENSG00000135517-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000135517-MONOMER
COXPRESdb	4284	http://coxpresdb.jp/data/gene/4284.shtml
CleanEx	HS_MIP	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_MIP
DOI	10.1016/0888-7543(91)90023-8	http://dx.doi.org/10.1016/0888-7543(91)90023-8
DOI	10.1016/j.ajo.2005.11.008	http://dx.doi.org/10.1016/j.ajo.2005.11.008
DOI	10.1016/j.exer.2012.10.010	http://dx.doi.org/10.1016/j.exer.2012.10.010
DOI	10.1016/j.exer.2013.09.019	http://dx.doi.org/10.1016/j.exer.2013.09.019
DOI	10.1038/75538	http://dx.doi.org/10.1038/75538
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1093/oxfordjournals.hmg.a018925	http://dx.doi.org/10.1093/oxfordjournals.hmg.a018925
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1371/journal.pone.0126679	http://dx.doi.org/10.1371/journal.pone.0126679
EMBL	AC024884	http://www.ebi.ac.uk/ena/data/view/AC024884
EMBL	BC074913	http://www.ebi.ac.uk/ena/data/view/BC074913
EMBL	BC117474	http://www.ebi.ac.uk/ena/data/view/BC117474
EMBL	U36308	http://www.ebi.ac.uk/ena/data/view/U36308
Ensembl	ENST00000257979	http://www.ensembl.org/id/ENST00000257979
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005921	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005921
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_function	GO:0005212	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005212
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0005243	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005243
GO_function	GO:0005516	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005516
GO_function	GO:0015250	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015250
GO_function	GO:0015254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015254
GO_process	GO:0002088	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002088
GO_process	GO:0006833	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006833
GO_process	GO:0007601	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007601
GO_process	GO:0009992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009992
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0045785	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045785
GO_process	GO:0050896	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050896
GO_process	GO:0051289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051289
GO_process	GO:1990349	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990349
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0005198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.1080.10	http://www.cathdb.info/version/latest/superfamily/1.20.1080.10
GeneCards	MIP	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=MIP
GeneID	4284	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4284
GeneTree	ENSGT00760000119223	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119223
HGNC	HGNC:7103	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:7103
HOGENOM	HOG000288286	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000288286&db=HOGENOM6
HOVERGEN	HBG000312	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000312&db=HOVERGEN
InParanoid	P30301	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30301
IntAct	P30301	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30301*
InterPro	IPR000425	http://www.ebi.ac.uk/interpro/entry/IPR000425
InterPro	IPR022357	http://www.ebi.ac.uk/interpro/entry/IPR022357
InterPro	IPR023271	http://www.ebi.ac.uk/interpro/entry/IPR023271
Jabion	4284	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=4284
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H01202	http://www.genome.jp/dbget-bin/www_bget?H01202
KEGG_Gene	hsa:4284	http://www.genome.jp/dbget-bin/www_bget?hsa:4284
KEGG_Orthology	KO:K09863	http://www.genome.jp/dbget-bin/www_bget?KO:K09863
MIM	154050	http://www.ncbi.nlm.nih.gov/omim/154050
MIM	615274	http://www.ncbi.nlm.nih.gov/omim/615274
MINT	MINT-8415310	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8415310
OMA	MWELRST	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MWELRST
Orphanet	98985	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98985
Orphanet	98989	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98989
Orphanet	98991	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98991
Orphanet	98994	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98994
Orphanet	98995	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98995
OrthoDB	EOG091G166T	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G166T
PANTHER	PTHR19139	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19139
PRINTS	PR00783	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00783
PROSITE	PS00221	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00221
PSORT	swissprot:MIP_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MIP_HUMAN
PSORT-B	swissprot:MIP_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MIP_HUMAN
PSORT2	swissprot:MIP_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MIP_HUMAN
Pfam	PF00230	http://pfam.xfam.org/family/PF00230
PharmGKB	PA30821	http://www.pharmgkb.org/do/serve?objId=PA30821&objCls=Gene
Phobius	swissprot:MIP_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MIP_HUMAN
PhylomeDB	P30301	http://phylomedb.org/?seqid=P30301
ProteinModelPortal	P30301	http://www.proteinmodelportal.org/query/uniprot/P30301
PubMed	10634618	http://www.ncbi.nlm.nih.gov/pubmed/10634618
PubMed	10802646	http://www.ncbi.nlm.nih.gov/pubmed/10802646
PubMed	11001937	http://www.ncbi.nlm.nih.gov/pubmed/11001937
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	16564824	http://www.ncbi.nlm.nih.gov/pubmed/16564824
PubMed	17893667	http://www.ncbi.nlm.nih.gov/pubmed/17893667
PubMed	17960133	http://www.ncbi.nlm.nih.gov/pubmed/17960133
PubMed	1840563	http://www.ncbi.nlm.nih.gov/pubmed/1840563
PubMed	20361015	http://www.ncbi.nlm.nih.gov/pubmed/20361015
PubMed	21245956	http://www.ncbi.nlm.nih.gov/pubmed/21245956
PubMed	23116563	http://www.ncbi.nlm.nih.gov/pubmed/23116563
PubMed	24120416	http://www.ncbi.nlm.nih.gov/pubmed/24120416
PubMed	25946197	http://www.ncbi.nlm.nih.gov/pubmed/25946197
Reactome	R-HSA-432047	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432047
RefSeq	NP_036196	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_036196
SMR	P30301	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30301
STRING	9606.ENSP00000257979	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000257979&targetmode=cogs
SUPFAM	SSF81338	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81338
TIGRFAMs	TIGR00861	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00861
UCSC	uc001slh	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001slh&org=rat
UniGene	Hs.574026	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.574026
UniProtKB	MIP_HUMAN	http://www.uniprot.org/uniprot/MIP_HUMAN
UniProtKB-AC	P30301	http://www.uniprot.org/uniprot/P30301
charge	swissprot:MIP_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MIP_HUMAN
eggNOG	COG0580	http://eggnogapi.embl.de/nog_data/html/tree/COG0580
eggNOG	KOG0223	http://eggnogapi.embl.de/nog_data/html/tree/KOG0223
epestfind	swissprot:MIP_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MIP_HUMAN
garnier	swissprot:MIP_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MIP_HUMAN
helixturnhelix	swissprot:MIP_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MIP_HUMAN
hmoment	swissprot:MIP_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MIP_HUMAN
iep	swissprot:MIP_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MIP_HUMAN
inforesidue	swissprot:MIP_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MIP_HUMAN
neXtProt	NX_P30301	http://www.nextprot.org/db/entry/NX_P30301
octanol	swissprot:MIP_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MIP_HUMAN
pepcoil	swissprot:MIP_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MIP_HUMAN
pepdigest	swissprot:MIP_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MIP_HUMAN
pepinfo	swissprot:MIP_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MIP_HUMAN
pepnet	swissprot:MIP_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MIP_HUMAN
pepstats	swissprot:MIP_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MIP_HUMAN
pepwheel	swissprot:MIP_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MIP_HUMAN
pepwindow	swissprot:MIP_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MIP_HUMAN
sigcleave	swissprot:MIP_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MIP_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SIDT2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8NBJ9-1; Sequence=Displayed; Name=2; IsoId=Q8NBJ9-2; Sequence=VSP_013523, VSP_013524; Note=No experimental confirmation available.; 
# BioGrid	119281	16
# CCDS	CCDS31682	-. [Q8NBJ9-1]
# ChiTaRS	SIDT2	human
# Ensembl	ENST00000324225	ENSP00000314023; ENSG00000149577. [Q8NBJ9-1]
# Ensembl	ENST00000620360	ENSP00000482762; ENSG00000149577. [Q8NBJ9-1]
# ExpressionAtlas	Q8NBJ9	baseline and differential
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0003725	double-stranded RNA binding; IEA:Ensembl.
# GO_function	GO:0051033	RNA transmembrane transporter activity; IEA:InterPro.
# GO_process	GO:0000902	cell morphogenesis; IEA:Ensembl.
# GO_process	GO:0003323	type B pancreatic cell development; IEA:Ensembl.
# GO_process	GO:0009749	response to glucose; IEA:Ensembl.
# GO_process	GO:0033227	dsRNA transport; IEA:InterPro.
# GO_process	GO:0042593	glucose homeostasis; IEA:Ensembl.
# GO_process	GO:0044342	type B pancreatic cell proliferation; IEA:Ensembl.
# GO_process	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0003723	RNA binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0000902	cell morphogenesis
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0008283	cell proliferation
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# Genevisible	Q8NBJ9	HS
# HGNC	HGNC:24272	SIDT2
# IntAct	Q8NBJ9	2
# InterPro	IPR025958	SID1_TM_fam
# Organism	SIDT2_HUMAN	Homo sapiens (Human)
# PTM	SIDT2_HUMAN	Glycosylated. {ECO 0000250}. 
# Pfam	PF13965	SID-1_RNA_chan
# Proteomes	UP000005640	Chromosome 11
# RecName	SIDT2_HUMAN	SID1 transmembrane family member 2
# RefSeq	NP_001035545	NM_001040455.1. [Q8NBJ9-1]
# SEQUENCE CAUTION	Sequence=BAC11427.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC11641.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the SID1 family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	SIDT2_HUMAN	Lysosome membrane {ECO 0000269|PubMed 17897319}; Multi-pass membrane protein {ECO 0000269|PubMed 17897319}. 
# TCDB	1.A.79.1	the cholesterol uptake protein (chup) or double stranded rna uptake family
# UCSC	uc001pqh	human. [Q8NBJ9-1]
# eggNOG	ENOG410IF6Z	Eukaryota
# eggNOG	ENOG410XPBN	LUCA
BLAST	swissprot:SIDT2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SIDT2_HUMAN
COXPRESdb	51092	http://coxpresdb.jp/data/gene/51092.shtml
CleanEx	HS_SIDT2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SIDT2
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1093/dnares/12.2.117	http://dx.doi.org/10.1093/dnares/12.2.117
DOI	10.1101/gr.10.5.703	http://dx.doi.org/10.1101/gr.10.5.703
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1110/ps.04682504	http://dx.doi.org/10.1110/ps.04682504
DOI	10.1111/j.1600-0854.2007.00643.x	http://dx.doi.org/10.1111/j.1600-0854.2007.00643.x
EMBL	AF151799	http://www.ebi.ac.uk/ena/data/view/AF151799
EMBL	AK075137	http://www.ebi.ac.uk/ena/data/view/AK075137
EMBL	AK075471	http://www.ebi.ac.uk/ena/data/view/AK075471
EMBL	AY358442	http://www.ebi.ac.uk/ena/data/view/AY358442
Ensembl	ENST00000324225	http://www.ensembl.org/id/ENST00000324225
Ensembl	ENST00000620360	http://www.ensembl.org/id/ENST00000620360
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0003725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003725
GO_function	GO:0051033	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051033
GO_process	GO:0000902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000902
GO_process	GO:0003323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003323
GO_process	GO:0009749	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009749
GO_process	GO:0033227	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033227
GO_process	GO:0042593	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042593
GO_process	GO:0044342	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044342
GO_process	GO:0061178	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061178
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0003723	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0000902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000902
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0008283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008283
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GeneCards	SIDT2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SIDT2
GeneID	51092	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51092
GeneTree	ENSGT00390000010091	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000010091
H-InvDB	HIX0010161	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0010161
HGNC	HGNC:24272	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:24272
HOGENOM	HOG000020635	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000020635&db=HOGENOM6
HOVERGEN	HBG079188	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG079188&db=HOVERGEN
HPA	HPA052352	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA052352
InParanoid	Q8NBJ9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8NBJ9
IntAct	Q8NBJ9	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8NBJ9*
InterPro	IPR025958	http://www.ebi.ac.uk/interpro/entry/IPR025958
Jabion	51092	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=51092
KEGG_Gene	hsa:51092	http://www.genome.jp/dbget-bin/www_bget?hsa:51092
PSORT	swissprot:SIDT2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SIDT2_HUMAN
PSORT-B	swissprot:SIDT2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SIDT2_HUMAN
PSORT2	swissprot:SIDT2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SIDT2_HUMAN
Pfam	PF13965	http://pfam.xfam.org/family/PF13965
PharmGKB	PA134910333	http://www.pharmgkb.org/do/serve?objId=PA134910333&objCls=Gene
Phobius	swissprot:SIDT2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SIDT2_HUMAN
PhylomeDB	Q8NBJ9	http://phylomedb.org/?seqid=Q8NBJ9
ProteinModelPortal	Q8NBJ9	http://www.proteinmodelportal.org/query/uniprot/Q8NBJ9
PubMed	10810093	http://www.ncbi.nlm.nih.gov/pubmed/10810093
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15340161	http://www.ncbi.nlm.nih.gov/pubmed/15340161
PubMed	16303743	http://www.ncbi.nlm.nih.gov/pubmed/16303743
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	17897319	http://www.ncbi.nlm.nih.gov/pubmed/17897319
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
RefSeq	NP_001035545	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001035545
STRING	9606.ENSP00000314023	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000314023&targetmode=cogs
TCDB	1.A.79.1	http://www.tcdb.org/search/result.php?tc=1.A.79.1
UCSC	uc001pqh	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001pqh&org=rat
UniGene	Hs.712144	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.712144
UniProtKB	SIDT2_HUMAN	http://www.uniprot.org/uniprot/SIDT2_HUMAN
UniProtKB-AC	Q8NBJ9	http://www.uniprot.org/uniprot/Q8NBJ9
charge	swissprot:SIDT2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SIDT2_HUMAN
eggNOG	ENOG410IF6Z	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IF6Z
eggNOG	ENOG410XPBN	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPBN
epestfind	swissprot:SIDT2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SIDT2_HUMAN
garnier	swissprot:SIDT2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SIDT2_HUMAN
helixturnhelix	swissprot:SIDT2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SIDT2_HUMAN
hmoment	swissprot:SIDT2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SIDT2_HUMAN
iep	swissprot:SIDT2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SIDT2_HUMAN
inforesidue	swissprot:SIDT2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SIDT2_HUMAN
neXtProt	NX_Q8NBJ9	http://www.nextprot.org/db/entry/NX_Q8NBJ9
octanol	swissprot:SIDT2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SIDT2_HUMAN
pepcoil	swissprot:SIDT2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SIDT2_HUMAN
pepdigest	swissprot:SIDT2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SIDT2_HUMAN
pepinfo	swissprot:SIDT2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SIDT2_HUMAN
pepnet	swissprot:SIDT2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SIDT2_HUMAN
pepstats	swissprot:SIDT2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SIDT2_HUMAN
pepwheel	swissprot:SIDT2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SIDT2_HUMAN
pepwindow	swissprot:SIDT2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SIDT2_HUMAN
sigcleave	swissprot:SIDT2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SIDT2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	VATO_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99437-1; Sequence=Displayed; Name=2; IsoId=Q99437-2; Sequence=VSP_046288; Note=No experimental confirmation available. Gene prediction based on EST data.; 
# AltName	VATO_HUMAN	Vacuolar proton pump 21 kDa proteolipid subunit
# AltName	VATO_HUMAN	hATPL
# BioGrid	107016	7
# CCDS	CCDS41315	-. [Q99437-2]
# CCDS	CCDS505	-. [Q99437-1]
# ChiTaRS	ATP6V0B	human
# Ensembl	ENST00000236067	ENSP00000236067; ENSG00000117410. [Q99437-2]
# Ensembl	ENST00000472174	ENSP00000431605; ENSG00000117410. [Q99437-1]
# Ensembl	ENST00000498664	ENSP00000434094; ENSG00000117410. [Q99437-2]
# ExpressionAtlas	Q99437	baseline and differential
# FUNCTION	VATO_HUMAN	Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. 
# GO_component	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain; IBA:GO_Central.
# GO_component	GO:0010008	endosome membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_component	GO:0030670	phagocytic vesicle membrane; TAS:Reactome.
# GO_function	GO:0005215	transporter activity; TAS:ProtInc.
# GO_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
# GO_process	GO:0007035	vacuolar acidification; IBA:GO_Central.
# GO_process	GO:0008286	insulin receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0015991	ATP hydrolysis coupled proton transport; IEA:InterPro.
# GO_process	GO:0015992	proton transport; TAS:ProtInc.
# GO_process	GO:0016241	regulation of macroautophagy; NAS:ParkinsonsUK-UCL.
# GO_process	GO:0033572	transferrin transport; TAS:Reactome.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0090383	phagosome acidification; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q99437	HS
# HGNC	HGNC:861	ATP6V0B
# IntAct	Q99437	4
# InterPro	IPR000245	ATPase_proteolipid_csu
# InterPro	IPR002379	ATPase_proteolipid_c-like_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04142	Lysosome
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko05110	Vibrio cholerae infection
# KEGG_Pathway	ko05120	Epithelial cell signaling in Helicobacter pylori infection
# KEGG_Pathway	ko05152	Tuberculosis
# KEGG_Pathway	ko05323	Rheumatoid arthritis
# MIM	603717	gene
# Organism	VATO_HUMAN	Homo sapiens (Human)
# PRINTS	PR00122	VACATPASE
# Pfam	PF00137	ATP-synt_C; 2
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-1222556	ROS, RNS production in response to bacteria
# Reactome	R-HSA-77387	Insulin receptor recycling
# Reactome	R-HSA-917977	Transferrin endocytosis and recycling
# Reactome	R-HSA-983712	Ion channel transport
# RecName	VATO_HUMAN	V-type proton ATPase 21 kDa proteolipid subunit
# RefSeq	NP_001034546	NM_001039457.2. [Q99437-2]
# RefSeq	NP_004038	NM_004047.4. [Q99437-1]
# SIMILARITY	Belongs to the V-ATPase proteolipid subunit family. {ECO	0000305}.
# SUBCELLULAR LOCATION	VATO_HUMAN	Vacuole membrane; Multi-pass membrane protein. 
# SUBUNIT	Interacts with IFITM3. {ECO	0000250}. 
# SUPFAM	SSF81333	SSF81333; 2
# TISSUE SPECIFICITY	VATO_HUMAN	Ubiquitous. 
# UCSC	uc001cld	human. [Q99437-1]
# eggNOG	COG0636	LUCA
# eggNOG	KOG0233	Eukaryota
BLAST	swissprot:VATO_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VATO_HUMAN
BioCyc	MetaCyc:ENSG00000117410-MONOMER	http://biocyc.org/getid?id=MetaCyc:ENSG00000117410-MONOMER
BioCyc	ZFISH:ENSG00000117410-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000117410-MONOMER
COG	COG0636	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0636
COXPRESdb	533	http://coxpresdb.jp/data/gene/533.shtml
CleanEx	HS_ATP6V0B	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP6V0B
DOI	10.1006/geno.1998.5310	http://dx.doi.org/10.1006/geno.1998.5310
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
EMBL	AL357079	http://www.ebi.ac.uk/ena/data/view/AL357079
EMBL	BC000423	http://www.ebi.ac.uk/ena/data/view/BC000423
EMBL	BC005876	http://www.ebi.ac.uk/ena/data/view/BC005876
EMBL	BT007151	http://www.ebi.ac.uk/ena/data/view/BT007151
EMBL	CH471059	http://www.ebi.ac.uk/ena/data/view/CH471059
EMBL	CH471059	http://www.ebi.ac.uk/ena/data/view/CH471059
EMBL	CH471059	http://www.ebi.ac.uk/ena/data/view/CH471059
EMBL	CR456972	http://www.ebi.ac.uk/ena/data/view/CR456972
EMBL	D89052	http://www.ebi.ac.uk/ena/data/view/D89052
Ensembl	ENST00000236067	http://www.ensembl.org/id/ENST00000236067
Ensembl	ENST00000472174	http://www.ensembl.org/id/ENST00000472174
Ensembl	ENST00000498664	http://www.ensembl.org/id/ENST00000498664
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000220
GO_component	GO:0010008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010008
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030670	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030670
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0046961	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046961
GO_process	GO:0007035	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007035
GO_process	GO:0008286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008286
GO_process	GO:0015991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015991
GO_process	GO:0015992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992
GO_process	GO:0016241	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016241
GO_process	GO:0033572	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033572
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0090383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090383
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ATP6V0B	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP6V0B
GeneID	533	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=533
GeneTree	ENSGT00550000075120	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000075120
HGNC	HGNC:861	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:861
HOGENOM	HOG000056522	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000056522&db=HOGENOM6
HOVERGEN	HBG105033	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG105033&db=HOVERGEN
HPA	HPA044281	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA044281
InParanoid	Q99437	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q99437
IntAct	Q99437	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q99437*
InterPro	IPR000245	http://www.ebi.ac.uk/interpro/entry/IPR000245
InterPro	IPR002379	http://www.ebi.ac.uk/interpro/entry/IPR002379
Jabion	533	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=533
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:533	http://www.genome.jp/dbget-bin/www_bget?hsa:533
KEGG_Orthology	KO:K03661	http://www.genome.jp/dbget-bin/www_bget?KO:K03661
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04142	http://www.genome.jp/kegg-bin/show_pathway?ko04142
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko05110	http://www.genome.jp/kegg-bin/show_pathway?ko05110
KEGG_Pathway	ko05120	http://www.genome.jp/kegg-bin/show_pathway?ko05120
KEGG_Pathway	ko05152	http://www.genome.jp/kegg-bin/show_pathway?ko05152
KEGG_Pathway	ko05323	http://www.genome.jp/kegg-bin/show_pathway?ko05323
MIM	603717	http://www.ncbi.nlm.nih.gov/omim/603717
PRINTS	PR00122	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00122
PSORT	swissprot:VATO_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VATO_HUMAN
PSORT-B	swissprot:VATO_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VATO_HUMAN
PSORT2	swissprot:VATO_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VATO_HUMAN
Pfam	PF00137	http://pfam.xfam.org/family/PF00137
PharmGKB	PA25148	http://www.pharmgkb.org/do/serve?objId=PA25148&objCls=Gene
Phobius	swissprot:VATO_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VATO_HUMAN
PhylomeDB	Q99437	http://phylomedb.org/?seqid=Q99437
ProteinModelPortal	Q99437	http://www.proteinmodelportal.org/query/uniprot/Q99437
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	9653649	http://www.ncbi.nlm.nih.gov/pubmed/9653649
Reactome	R-HSA-1222556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1222556
Reactome	R-HSA-77387	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-77387
Reactome	R-HSA-917977	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917977
Reactome	R-HSA-983712	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983712
RefSeq	NP_001034546	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001034546
RefSeq	NP_004038	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004038
STRING	9606.ENSP00000431605	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000431605&targetmode=cogs
STRING	COG0636	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0636&targetmode=cogs
SUPFAM	SSF81333	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81333
UCSC	uc001cld	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001cld&org=rat
UniGene	Hs.596514	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.596514
UniProtKB	VATO_HUMAN	http://www.uniprot.org/uniprot/VATO_HUMAN
UniProtKB-AC	Q99437	http://www.uniprot.org/uniprot/Q99437
charge	swissprot:VATO_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VATO_HUMAN
eggNOG	COG0636	http://eggnogapi.embl.de/nog_data/html/tree/COG0636
eggNOG	KOG0233	http://eggnogapi.embl.de/nog_data/html/tree/KOG0233
epestfind	swissprot:VATO_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VATO_HUMAN
garnier	swissprot:VATO_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VATO_HUMAN
helixturnhelix	swissprot:VATO_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VATO_HUMAN
hmoment	swissprot:VATO_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VATO_HUMAN
iep	swissprot:VATO_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VATO_HUMAN
inforesidue	swissprot:VATO_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VATO_HUMAN
neXtProt	NX_Q99437	http://www.nextprot.org/db/entry/NX_Q99437
octanol	swissprot:VATO_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VATO_HUMAN
pepcoil	swissprot:VATO_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VATO_HUMAN
pepdigest	swissprot:VATO_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VATO_HUMAN
pepinfo	swissprot:VATO_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VATO_HUMAN
pepnet	swissprot:VATO_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VATO_HUMAN
pepstats	swissprot:VATO_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VATO_HUMAN
pepwheel	swissprot:VATO_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VATO_HUMAN
pepwindow	swissprot:VATO_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VATO_HUMAN
sigcleave	swissprot:VATO_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VATO_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	MOT14_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7RTX9-1; Sequence=Displayed; Name=2; IsoId=Q7RTX9-2; Sequence=VSP_025826; Note=No experimental confirmation available.; 
# AltName	MOT14_HUMAN	Solute carrier family 16 member 14
# BioGrid	127380	3
# CCDS	CCDS2473	-. [Q7RTX9-1]
# CDD	cd06174	MFS
# Ensembl	ENST00000295190	ENSP00000295190; ENSG00000163053. [Q7RTX9-1]
# ExpressionAtlas	Q7RTX9	baseline and differential
# FUNCTION	MOT14_HUMAN	Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane. {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016021	integral component of membrane; IBA:GO_Central.
# GO_function	GO:0008028	monocarboxylic acid transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# Genevisible	Q7RTX9	HS
# HGNC	HGNC:26417	SLC16A14
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# Organism	MOT14_HUMAN	Homo sapiens (Human)
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 2
# RecName	MOT14_HUMAN	Monocarboxylate transporter 14
# RefSeq	NP_689740	NM_152527.4. [Q7RTX9-1]
# RefSeq	XP_011509053	XM_011510751.2. [Q7RTX9-1]
# RefSeq	XP_016858969	XM_017003480.1. [Q7RTX9-1]
# SIMILARITY	Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	MOT14_HUMAN	Cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.1.13.12	the major facilitator superfamily (mfs)
# UCSC	uc002vqd	human. [Q7RTX9-1]
# eggNOG	ENOG411000Y	LUCA
# eggNOG	KOG2504	Eukaryota
BLAST	swissprot:MOT14_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MOT14_HUMAN
COXPRESdb	151473	http://coxpresdb.jp/data/gene/151473.shtml
CleanEx	HS_SLC16A14	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC16A14
DOI	10.1007/s00424-003-1067-2	http://dx.doi.org/10.1007/s00424-003-1067-2
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC093171	http://www.ebi.ac.uk/ena/data/view/AC093171
EMBL	AK055356	http://www.ebi.ac.uk/ena/data/view/AK055356
EMBL	AK292873	http://www.ebi.ac.uk/ena/data/view/AK292873
EMBL	BC065524	http://www.ebi.ac.uk/ena/data/view/BC065524
EMBL	BN000146	http://www.ebi.ac.uk/ena/data/view/BN000146
EMBL	CH471063	http://www.ebi.ac.uk/ena/data/view/CH471063
Ensembl	ENST00000295190	http://www.ensembl.org/id/ENST00000295190
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0008028	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008028
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GeneCards	SLC16A14	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC16A14
GeneID	151473	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=151473
GeneTree	ENSGT00760000118926	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118926
HGNC	HGNC:26417	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:26417
HOGENOM	HOG000013205	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000013205&db=HOGENOM6
HOVERGEN	HBG094888	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG094888&db=HOVERGEN
HPA	HPA040518	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA040518
InParanoid	Q7RTX9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q7RTX9
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	151473	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=151473
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:151473	http://www.genome.jp/dbget-bin/www_bget?hsa:151473
KEGG_Orthology	KO:K08190	http://www.genome.jp/dbget-bin/www_bget?KO:K08190
OMA	CGLLYMI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CGLLYMI
OrthoDB	EOG091G04XL	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G04XL
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:MOT14_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MOT14_HUMAN
PSORT-B	swissprot:MOT14_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MOT14_HUMAN
PSORT2	swissprot:MOT14_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MOT14_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA134983567	http://www.pharmgkb.org/do/serve?objId=PA134983567&objCls=Gene
Phobius	swissprot:MOT14_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MOT14_HUMAN
PhylomeDB	Q7RTX9	http://phylomedb.org/?seqid=Q7RTX9
ProteinModelPortal	Q7RTX9	http://www.proteinmodelportal.org/query/uniprot/Q7RTX9
PubMed	12739169	http://www.ncbi.nlm.nih.gov/pubmed/12739169
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
RefSeq	NP_689740	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_689740
RefSeq	XP_011509053	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011509053
RefSeq	XP_016858969	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016858969
STRING	9606.ENSP00000295190	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000295190&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.13.12	http://www.tcdb.org/search/result.php?tc=2.A.1.13.12
UCSC	uc002vqd	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002vqd&org=rat
UniGene	Hs.504317	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.504317
UniProtKB	MOT14_HUMAN	http://www.uniprot.org/uniprot/MOT14_HUMAN
UniProtKB-AC	Q7RTX9	http://www.uniprot.org/uniprot/Q7RTX9
charge	swissprot:MOT14_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MOT14_HUMAN
eggNOG	ENOG411000Y	http://eggnogapi.embl.de/nog_data/html/tree/ENOG411000Y
eggNOG	KOG2504	http://eggnogapi.embl.de/nog_data/html/tree/KOG2504
epestfind	swissprot:MOT14_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MOT14_HUMAN
garnier	swissprot:MOT14_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MOT14_HUMAN
helixturnhelix	swissprot:MOT14_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MOT14_HUMAN
hmoment	swissprot:MOT14_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MOT14_HUMAN
iep	swissprot:MOT14_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MOT14_HUMAN
inforesidue	swissprot:MOT14_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MOT14_HUMAN
neXtProt	NX_Q7RTX9	http://www.nextprot.org/db/entry/NX_Q7RTX9
octanol	swissprot:MOT14_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MOT14_HUMAN
pepcoil	swissprot:MOT14_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MOT14_HUMAN
pepdigest	swissprot:MOT14_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MOT14_HUMAN
pepinfo	swissprot:MOT14_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MOT14_HUMAN
pepnet	swissprot:MOT14_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MOT14_HUMAN
pepstats	swissprot:MOT14_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MOT14_HUMAN
pepwheel	swissprot:MOT14_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MOT14_HUMAN
pepwindow	swissprot:MOT14_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MOT14_HUMAN
sigcleave	swissprot:MOT14_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MOT14_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AT2A2_HUMAN	Event=Alternative splicing; Named isoforms=5; Comment=SERCA2 transcripts differ only in their 3'-UTR region and are expressed in a tissue-specific manner.; Name=1; Synonyms=ATP2A2B, Class 2-4, HK1, SERCA2b; IsoId=P16615-1; Sequence=Displayed; Note=Ubiquitous housekeeping isoform.; Name=2; Synonyms=ATP2A2A, Class 1, HK2, SERCA2a; IsoId=P16615-2; Sequence=VSP_000358; Note=Cardiac/slow twitch, muscle specific isoform. Has a lower affinity for calcium and a higher catalytic turnover rate.; Name=3; Synonyms=SERCA2C; IsoId=P16615-3; Sequence=VSP_039393; Note=May be due to intron retention. Shows a lower apparent affinity for cytosolic calcium than isoform 2 and a catalytic turnover rate similar to isoform 1.; Name=4; IsoId=P16615-4; Sequence=VSP_039392; Note=No experimental confirmation available.; Name=5; IsoId=P16615-5; Sequence=VSP_039394; Note=No experimental confirmation available.; 
# AltName	AT2A2_HUMAN	Calcium pump 2
# AltName	AT2A2_HUMAN	Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform
# AltName	AT2A2_HUMAN	Endoplasmic reticulum class 1/2 Ca(2+) ATPase
# BioGrid	106978	70
# CATALYTIC ACTIVITY	AT2A2_HUMAN	ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2). 
# CCDS	CCDS9143	-. [P16615-2]
# CCDS	CCDS9144	-. [P16615-1]
# ChiTaRS	ATP2A2	human
# DISEASE	AT2A2_HUMAN	Acrokeratosis verruciformis (AKV) [MIM 101900]  A localized disorder of keratinization, which is inherited as an autosomal dominant trait. Its onset is early in life with multiple flat-topped, flesh-colored papules on the hands and feet, punctate keratoses on the palms and soles, with varying degrees of nail involvement. The histopathology shows a distinctive pattern of epidermal features with hyperkeratosis, hypergranulosis and acanthosis together with papillomatosis. These changes are frequently associated with circumscribed elevations of the epidermis that are said to resemble church spires. There are no features of dyskeratosis or acantholysis, the typical findings in lesions of Darier disease. {ECO 0000269|PubMed 12542527}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	AT2A2_HUMAN	Darier disease (DD) [MIM 124200]  A skin disorder characterized by warty papules and plaques in seborrheic areas (central trunk, flexures, scalp and forehead), palmoplantar pits and distinctive nail abnormalities. It is due to loss of adhesion between epidermal cells (acantholysis) and abnormal keratinization. Patients with mild disease may have no more than a few scattered keratotic papules or subtle nail changes, whereas those with severe disease are handicapped by widespread malodorous keratotic plaques. Some patients present with hemorrhage into acantholytic vesicles on the palms and dorsal aspects of the fingers which gives rise to black macules. In a few families affected by Darier disease, neuropsychiatric abnormalities such as mild mental retardation, schizophrenia, bipolar disorder and epilepsy have been reported. Stress, UV exposure, heat, sweat, friction and oral contraception exacerbate disease symptoms. Clinical variants of Darier disease include hypertrophic, vesicobullous, hypopigmented, cornifying, zosteriform or linear, acute and comedonal subtypes. Comedonal Darier disease is characterized by the coexistence of acne-like comedonal lesions with typical Darier hyperkeratotic papules on light-exposed areas. At histopathologic level, comedonal Darier disease differs from classic Darier disease in the prominent follicular involvement and the presence of greatly elongated dermal villi. {ECO 0000269|PubMed 10080178, ECO 0000269|PubMed 10441323, ECO 0000269|PubMed 10441324, ECO 0000269|PubMed 10441325, ECO 0000269|PubMed 19995371}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# ENZYME REGULATION	AT2A2_HUMAN	Reversibly inhibited by phospholamban (PLN) at low calcium concentrations (By similarity). Inhibited by sarcolipin (SLN) and myoregulin (MRLN) (By similarity). Enhanced by DWORF; DWORF increases activity by displacing sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN) (By similarity). {ECO 0000250|UniProtKB O55143, ECO 0000250|UniProtKB P04191, ECO 0000250|UniProtKB Q8R429}. 
# Ensembl	ENST00000308664	ENSP00000311186; ENSG00000174437. [P16615-2]
# Ensembl	ENST00000539276	ENSP00000440045; ENSG00000174437. [P16615-1]
# ExpressionAtlas	P16615	baseline and differential
# FUNCTION	AT2A2_HUMAN	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle (PubMed 16402920). Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11- induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation (By similarity). {ECO 0000250|UniProtKB O55143, ECO 0000269|PubMed 16402920}. 
# GO_component	GO:0005783	endoplasmic reticulum; IDA:UniProtKB.
# GO_component	GO:0005789	endoplasmic reticulum membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0012506	vesicle membrane; IEA:Ensembl.
# GO_component	GO:0014801	longitudinal sarcoplasmic reticulum; IDA:BHF-UCL.
# GO_component	GO:0016020	membrane; IDA:MGI.
# GO_component	GO:0016529	sarcoplasmic reticulum; IDA:BHF-UCL.
# GO_component	GO:0031095	platelet dense tubular network membrane; TAS:Reactome.
# GO_component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane; IEA:Ensembl.
# GO_component	GO:0033017	sarcoplasmic reticulum membrane; TAS:BHF-UCL.
# GO_component	GO:0043234	protein complex; IEA:Ensembl.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IEA:Ensembl.
# GO_component	GO:0090534	calcium ion-transporting ATPase complex; IDA:BHF-UCL.
# GO_component	GO:0097470	ribbon synapse; IEA:Ensembl.
# GO_function	GO:0005388	calcium-transporting ATPase activity; IDA:BHF-UCL.
# GO_function	GO:0005509	calcium ion binding; IDA:BHF-UCL.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0008022	protein C-terminus binding; IPI:UniProtKB.
# GO_function	GO:0019899	enzyme binding; IPI:BHF-UCL.
# GO_function	GO:0044548	S100 protein binding; IPI:UniProtKB.
# GO_function	GO:0086039	calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential; ISS:BHF-UCL.
# GO_process	GO:0002026	regulation of the force of heart contraction; IEA:Ensembl.
# GO_process	GO:0006874	cellular calcium ion homeostasis; IDA:BHF-UCL.
# GO_process	GO:0006984	ER-nucleus signaling pathway; IEA:Ensembl.
# GO_process	GO:0006996	organelle organization; IEA:Ensembl.
# GO_process	GO:0007155	cell adhesion; TAS:ProtInc.
# GO_process	GO:0008544	epidermis development; TAS:ProtInc.
# GO_process	GO:0010460	positive regulation of heart rate; TAS:BHF-UCL.
# GO_process	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling; IDA:BHF-UCL.
# GO_process	GO:0014883	transition between fast and slow fiber; IEA:Ensembl.
# GO_process	GO:0014898	cardiac muscle hypertrophy in response to stress; IEA:Ensembl.
# GO_process	GO:0032469	endoplasmic reticulum calcium ion homeostasis; IDA:BHF-UCL.
# GO_process	GO:0032470	positive regulation of endoplasmic reticulum calcium ion concentration; IDA:BHF-UCL.
# GO_process	GO:0033292	T-tubule organization; IEA:Ensembl.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0034599	cellular response to oxidative stress; IEA:Ensembl.
# GO_process	GO:0034976	response to endoplasmic reticulum stress; ISS:ParkinsonsUK-UCL.
# GO_process	GO:0043434	response to peptide hormone; IEA:Ensembl.
# GO_process	GO:0045822	negative regulation of heart contraction; IEA:Ensembl.
# GO_process	GO:0055119	relaxation of cardiac muscle; IDA:BHF-UCL.
# GO_process	GO:0070296	sarcoplasmic reticulum calcium ion transport; TAS:BHF-UCL.
# GO_process	GO:0070588	calcium ion transmembrane transport; IDA:BHF-UCL.
# GO_process	GO:0086036	regulation of cardiac muscle cell membrane potential; ISS:BHF-UCL.
# GO_process	GO:0098909	regulation of cardiac muscle cell action potential involved in regulation of contraction; ISS:BHF-UCL.
# GO_process	GO:1903233	regulation of calcium ion-dependent exocytosis of neurotransmitter; IEA:Ensembl.
# GO_process	GO:1903515	calcium ion transport from cytosol to endoplasmic reticulum; IDA:BHF-UCL.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GO_process	GO:1990036	calcium ion import into sarcoplasmic reticulum; ISS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007155	cell adhesion
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# GOslim_process	GO:0061024	membrane organization
# Gene3D	1.20.1110.10	-; 2.
# Gene3D	2.70.150.10	-; 2.
# Gene3D	3.40.1110.10	-; 1.
# Genevisible	P16615	HS
# HGNC	HGNC:812	ATP2A2
# INTERACTION	AT2A2_HUMAN	P41143 OPRD1; NbExp=3; IntAct=EBI-358933, EBI-2624456; 
# IntAct	P16615	65
# InterPro	IPR001757	P_typ_ATPase
# InterPro	IPR004014	ATPase_P-typ_cation-transptr_N
# InterPro	IPR005782	P-type_ATPase_IIA
# InterPro	IPR006068	ATPase_P-typ_cation-transptr_C
# InterPro	IPR008250	ATPase_P-typ_transduc_dom_A
# InterPro	IPR018303	ATPase_P-typ_P_site
# InterPro	IPR023214	HAD-like_dom
# InterPro	IPR023298	ATPase_P-typ_TM_dom
# InterPro	IPR023299	ATPase_P-typ_cyto_domN
# InterPro	IPR030327	SERCA2
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Disease	H00715	[Skin and connective tissue disease] Dyskeratosis follicularis
# KEGG_Disease	H00755	[Skin and connective tissue disease] Acrokeratosis verruciformis
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04972	Pancreatic secretion
# KEGG_Pathway	ko05010	Alzheimer's disease
# MIM	101900	phenotype
# MIM	108740	gene
# MIM	124200	phenotype
# Organism	AT2A2_HUMAN	Homo sapiens (Human)
# Orphanet	218	Darier disease
# Orphanet	79151	Acrokeratosis verruciformis of Hopf
# PANTHER	PTHR24093:SF234	PTHR24093:SF234; 2
# PIR	A31981	A31981
# PIR	B31981	B31981
# PRINTS	PR00120	HATPASE
# PROSITE	PS00154	ATPASE_E1_E2
# PTM	AT2A2_HUMAN	Nitrated under oxidative stress. Nitration on the two tyrosine residues inhibits catalytic activity. {ECO 0000269|PubMed 16399855}. 
# Pfam	PF00122	E1-E2_ATPase
# Pfam	PF00689	Cation_ATPase_C
# Pfam	PF00690	Cation_ATPase_N
# Pfam	PF08282	Hydrolase_3
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-1912420	Pre-NOTCH Processing in Golgi
# Reactome	R-HSA-418359	Reduction of cytosolic Ca++ levels
# Reactome	R-HSA-5578775	Ion homeostasis
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	AT2A2_HUMAN	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
# RefSeq	NP_001672	NM_001681.3. [P16615-2]
# RefSeq	NP_733765	NM_170665.3. [P16615-1]
# RefSeq	XP_005253945	XM_005253888.2. [P16615-3]
# RefSeq	XP_011536704	XM_011538402.2. [P16615-3]
# SEQUENCE CAUTION	Sequence=BAG57266.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. {ECO	0000305}. 
# SMART	SM00831	Cation_ATPase_N
# SUBCELLULAR LOCATION	AT2A2_HUMAN	Endoplasmic reticulum membrane {ECO 0000250|UniProtKB O55143}; Multi-pass membrane protein {ECO 0000255}. Sarcoplasmic reticulum membrane {ECO 0000250|UniProtKB O55143}; Multi-pass membrane protein {ECO 0000255}. 
# SUBUNIT	AT2A2_HUMAN	Interacts with sarcolipin (SLN) (By similarity). Interacts with phospholamban (PLN) (By similarity). Interacts with myoregulin (MRLN) (By similarity). Interacts with DWORF (By similarity). Isoform 1 interacts with TRAM2 (via C-terminus) (PubMed 14749390). Interacts with HAX1 (PubMed 18971376). Interacts with S100A8 and S100A9 (By similarity). Interacts with SLC35G1 and STIM1 (PubMed 22084111). Interacts with TMEM203 (PubMed 25996873). Interacts with TMEM64 and PDIA3 (By similarity). {ECO 0000250|UniProtKB O55143, ECO 0000250|UniProtKB P04191, ECO 0000250|UniProtKB Q8R429, ECO 0000269|PubMed 14749390, ECO 0000269|PubMed 18971376, ECO 0000269|PubMed 22084111, ECO 0000269|PubMed 25996873}. 
# SUPFAM	SSF56784	SSF56784
# SUPFAM	SSF81660	SSF81660
# TCDB	3.A.3.2	the p-type atpase (p-atpase) superfamily
# TIGRFAMs	TIGR01116	ATPase-IIA1_Ca
# TIGRFAMs	TIGR01494	ATPase_P-type; 2
# TISSUE SPECIFICITY	AT2A2_HUMAN	Isoform 1 is widely expressed in smooth muscle and nonmuscle tissues such as in adult skin epidermis, with highest expression in liver, pancreas and lung, and intermediate expression in brain, kidney and placenta. Also expressed at lower levels in heart and skeletal muscle. Isoforms 2 and 3 are highly expressed in the heart and slow twitch skeletal muscle. Expression of isoform 3 is predominantly restricted to cardiomyocytes and in close proximity to the sarcolemma. Both isoforms are mildly expressed in lung, kidney, liver, pancreas and placenta. Expression of isoform 3 is amplified during monocytic differentiation and also observed in the fetal heart. {ECO 0000269|PubMed 10441324, ECO 0000269|PubMed 12659872, ECO 0000269|PubMed 16402920}. 
# UCSC	uc001tqk	human. [P16615-1]
# eggNOG	COG0474	LUCA
# eggNOG	KOG0202	Eukaryota
BLAST	swissprot:AT2A2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AT2A2_HUMAN
BioCyc	ZFISH:HS10797-MONOMER	http://biocyc.org/getid?id=ZFISH:HS10797-MONOMER
COXPRESdb	488	http://coxpresdb.jp/data/gene/488.shtml
CleanEx	HS_ATP2A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP2A2
DIP	DIP-33868N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-33868N
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/S0006-291X(03)00405-4	http://dx.doi.org/10.1016/S0006-291X(03)00405-4
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/6784	http://dx.doi.org/10.1038/6784
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/BJ20051427	http://dx.doi.org/10.1042/BJ20051427
DOI	10.1046/j.1523-1747.2003.t01-1-12045.x	http://dx.doi.org/10.1046/j.1523-1747.2003.t01-1-12045.x
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.1117231108	http://dx.doi.org/10.1073/pnas.1117231108
DOI	10.1091/mbc.E08-06-0587	http://dx.doi.org/10.1091/mbc.E08-06-0587
DOI	10.1093/hmg/8.9.1611	http://dx.doi.org/10.1093/hmg/8.9.1611
DOI	10.1093/hmg/8.9.1621	http://dx.doi.org/10.1093/hmg/8.9.1621
DOI	10.1093/hmg/8.9.1631	http://dx.doi.org/10.1093/hmg/8.9.1631
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1365-2133.2009.09580.x	http://dx.doi.org/10.1111/j.1365-2133.2009.09580.x
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1128/MCB.24.4.1758-1768.2004	http://dx.doi.org/10.1128/MCB.24.4.1758-1768.2004
DOI	10.1152/ajpheart.01293.2005	http://dx.doi.org/10.1152/ajpheart.01293.2005
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1371/journal.pone.0127480	http://dx.doi.org/10.1371/journal.pone.0127480
EC_number	EC:3.6.3.8	http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.8
EMBL	AC006088	http://www.ebi.ac.uk/ena/data/view/AC006088
EMBL	AK293877	http://www.ebi.ac.uk/ena/data/view/AK293877
EMBL	AY186578	http://www.ebi.ac.uk/ena/data/view/AY186578
EMBL	BC035588	http://www.ebi.ac.uk/ena/data/view/BC035588
EMBL	M23114	http://www.ebi.ac.uk/ena/data/view/M23114
EMBL	M23115	http://www.ebi.ac.uk/ena/data/view/M23115
EMBL	M23116	http://www.ebi.ac.uk/ena/data/view/M23116
EMBL	M23116	http://www.ebi.ac.uk/ena/data/view/M23116
EMBL	M23278	http://www.ebi.ac.uk/ena/data/view/M23278
ENZYME	3.6.3.8	http://enzyme.expasy.org/EC/3.6.3.8
Ensembl	ENST00000308664	http://www.ensembl.org/id/ENST00000308664
Ensembl	ENST00000539276	http://www.ensembl.org/id/ENST00000539276
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0012506	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0012506
GO_component	GO:0014801	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014801
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016529	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016529
GO_component	GO:0031095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031095
GO_component	GO:0031234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031234
GO_component	GO:0033017	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033017
GO_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_component	GO:0090534	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090534
GO_component	GO:0097470	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097470
GO_function	GO:0005388	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005388
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0008022	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008022
GO_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GO_function	GO:0044548	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044548
GO_function	GO:0086039	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086039
GO_process	GO:0002026	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002026
GO_process	GO:0006874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874
GO_process	GO:0006984	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006984
GO_process	GO:0006996	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006996
GO_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GO_process	GO:0008544	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008544
GO_process	GO:0010460	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010460
GO_process	GO:0010882	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010882
GO_process	GO:0014883	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014883
GO_process	GO:0014898	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014898
GO_process	GO:0032469	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032469
GO_process	GO:0032470	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032470
GO_process	GO:0033292	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033292
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0034599	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034599
GO_process	GO:0034976	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034976
GO_process	GO:0043434	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043434
GO_process	GO:0045822	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045822
GO_process	GO:0055119	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055119
GO_process	GO:0070296	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070296
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:0086036	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086036
GO_process	GO:0098909	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098909
GO_process	GO:1903233	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903233
GO_process	GO:1903515	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903515
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GO_process	GO:1990036	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990036
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
Gene3D	1.20.1110.10	http://www.cathdb.info/version/latest/superfamily/1.20.1110.10
Gene3D	2.70.150.10	http://www.cathdb.info/version/latest/superfamily/2.70.150.10
Gene3D	3.40.1110.10	http://www.cathdb.info/version/latest/superfamily/3.40.1110.10
GeneCards	ATP2A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP2A2
GeneID	488	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=488
GeneTree	ENSGT00850000132256	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00850000132256
HGNC	HGNC:812	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:812
HOGENOM	HOG000265621	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265621&db=HOGENOM6
HOVERGEN	HBG105648	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG105648&db=HOVERGEN
HPA	HPA062605	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA062605
HPA	HPA067892	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA067892
InParanoid	P16615	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16615
IntAct	P16615	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16615*
IntEnz	3.6.3.8	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.8
InterPro	IPR001757	http://www.ebi.ac.uk/interpro/entry/IPR001757
InterPro	IPR004014	http://www.ebi.ac.uk/interpro/entry/IPR004014
InterPro	IPR005782	http://www.ebi.ac.uk/interpro/entry/IPR005782
InterPro	IPR006068	http://www.ebi.ac.uk/interpro/entry/IPR006068
InterPro	IPR008250	http://www.ebi.ac.uk/interpro/entry/IPR008250
InterPro	IPR018303	http://www.ebi.ac.uk/interpro/entry/IPR018303
InterPro	IPR023214	http://www.ebi.ac.uk/interpro/entry/IPR023214
InterPro	IPR023298	http://www.ebi.ac.uk/interpro/entry/IPR023298
InterPro	IPR023299	http://www.ebi.ac.uk/interpro/entry/IPR023299
InterPro	IPR030327	http://www.ebi.ac.uk/interpro/entry/IPR030327
Jabion	488	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=488
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Disease	H00715	http://www.genome.jp/dbget-bin/www_bget?H00715
KEGG_Disease	H00755	http://www.genome.jp/dbget-bin/www_bget?H00755
KEGG_Gene	hsa:488	http://www.genome.jp/dbget-bin/www_bget?hsa:488
KEGG_Orthology	KO:K05853	http://www.genome.jp/dbget-bin/www_bget?KO:K05853
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
MIM	101900	http://www.ncbi.nlm.nih.gov/omim/101900
MIM	108740	http://www.ncbi.nlm.nih.gov/omim/108740
MIM	124200	http://www.ncbi.nlm.nih.gov/omim/124200
MINT	MINT-4991144	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4991144
OMA	DDMIFLG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DDMIFLG
Orphanet	218	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=218
Orphanet	79151	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=79151
OrthoDB	EOG091G01LE	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01LE
PANTHER	PTHR24093:SF234	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24093:SF234
PRINTS	PR00120	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00120
PROSITE	PS00154	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00154
PSORT	swissprot:AT2A2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AT2A2_HUMAN
PSORT-B	swissprot:AT2A2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AT2A2_HUMAN
PSORT2	swissprot:AT2A2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AT2A2_HUMAN
Pfam	PF00122	http://pfam.xfam.org/family/PF00122
Pfam	PF00689	http://pfam.xfam.org/family/PF00689
Pfam	PF00690	http://pfam.xfam.org/family/PF00690
Pfam	PF08282	http://pfam.xfam.org/family/PF08282
PharmGKB	PA71	http://www.pharmgkb.org/do/serve?objId=PA71&objCls=Gene
Phobius	swissprot:AT2A2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AT2A2_HUMAN
PhylomeDB	P16615	http://phylomedb.org/?seqid=P16615
ProteinModelPortal	P16615	http://www.proteinmodelportal.org/query/uniprot/P16615
PubMed	10080178	http://www.ncbi.nlm.nih.gov/pubmed/10080178
PubMed	10441323	http://www.ncbi.nlm.nih.gov/pubmed/10441323
PubMed	10441324	http://www.ncbi.nlm.nih.gov/pubmed/10441324
PubMed	10441325	http://www.ncbi.nlm.nih.gov/pubmed/10441325
PubMed	12542527	http://www.ncbi.nlm.nih.gov/pubmed/12542527
PubMed	12659872	http://www.ncbi.nlm.nih.gov/pubmed/12659872
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	14749390	http://www.ncbi.nlm.nih.gov/pubmed/14749390
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16399855	http://www.ncbi.nlm.nih.gov/pubmed/16399855
PubMed	16402920	http://www.ncbi.nlm.nih.gov/pubmed/16402920
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	18971376	http://www.ncbi.nlm.nih.gov/pubmed/18971376
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	19995371	http://www.ncbi.nlm.nih.gov/pubmed/19995371
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22084111	http://www.ncbi.nlm.nih.gov/pubmed/22084111
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	25996873	http://www.ncbi.nlm.nih.gov/pubmed/25996873
PubMed	2844796	http://www.ncbi.nlm.nih.gov/pubmed/2844796
Reactome	R-HSA-1912420	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1912420
Reactome	R-HSA-418359	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418359
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_001672	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001672
RefSeq	NP_733765	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_733765
RefSeq	XP_005253945	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005253945
RefSeq	XP_011536704	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011536704
SMART	SM00831	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00831
SMR	P16615	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P16615
STRING	9606.ENSP00000440045	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000440045&targetmode=cogs
SUPFAM	SSF56784	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784
SUPFAM	SSF81660	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81660
TCDB	3.A.3.2	http://www.tcdb.org/search/result.php?tc=3.A.3.2
TIGRFAMs	TIGR01116	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01116
TIGRFAMs	TIGR01494	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01494
UCSC	uc001tqk	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001tqk&org=rat
UniGene	Hs.506759	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.506759
UniProtKB	AT2A2_HUMAN	http://www.uniprot.org/uniprot/AT2A2_HUMAN
UniProtKB-AC	P16615	http://www.uniprot.org/uniprot/P16615
charge	swissprot:AT2A2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AT2A2_HUMAN
eggNOG	COG0474	http://eggnogapi.embl.de/nog_data/html/tree/COG0474
eggNOG	KOG0202	http://eggnogapi.embl.de/nog_data/html/tree/KOG0202
epestfind	swissprot:AT2A2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AT2A2_HUMAN
garnier	swissprot:AT2A2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AT2A2_HUMAN
helixturnhelix	swissprot:AT2A2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AT2A2_HUMAN
hmoment	swissprot:AT2A2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AT2A2_HUMAN
iep	swissprot:AT2A2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AT2A2_HUMAN
inforesidue	swissprot:AT2A2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AT2A2_HUMAN
neXtProt	NX_P16615	http://www.nextprot.org/db/entry/NX_P16615
octanol	swissprot:AT2A2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AT2A2_HUMAN
pepcoil	swissprot:AT2A2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AT2A2_HUMAN
pepdigest	swissprot:AT2A2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AT2A2_HUMAN
pepinfo	swissprot:AT2A2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AT2A2_HUMAN
pepnet	swissprot:AT2A2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AT2A2_HUMAN
pepstats	swissprot:AT2A2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AT2A2_HUMAN
pepwheel	swissprot:AT2A2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AT2A2_HUMAN
pepwindow	swissprot:AT2A2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AT2A2_HUMAN
sigcleave	swissprot:AT2A2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AT2A2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SATT_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P43007-1; Sequence=Displayed; Name=2; IsoId=P43007-2; Sequence=VSP_042880, VSP_042881; Note=No experimental confirmation available.; 
# AltName	SATT_HUMAN	Alanine/serine/cysteine/threonine transporter 1
# AltName	SATT_HUMAN	SATT
# AltName	SATT_HUMAN	Solute carrier family 1 member 4
# BioGrid	112400	5
# CCDS	CCDS1879	-. [P43007-1]
# CCDS	CCDS54362	-. [P43007-2]
# ChiTaRS	SLC1A4	human
# DISEASE	SATT_HUMAN	Spastic tetraplegia, thin corpus callosum, and progressive microcephaly (SPATCCM) [MIM 616657]  A neurodevelopmental disorder characterized by thin corpus callosum, severe progressive microcephaly, severe intellectual disability, seizures, spasticity, and global developmental delay. Most patients are unable to achieve independent walking or speech. {ECO 0000269|PubMed 25930971, ECO 0000269|PubMed 26041762, ECO 0000269|PubMed 26138499}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00160	L-Alanine
# Ensembl	ENST00000234256	ENSP00000234256; ENSG00000115902. [P43007-1]
# Ensembl	ENST00000531327	ENSP00000431942; ENSG00000115902. [P43007-2]
# FUNCTION	SATT_HUMAN	Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence. {ECO 0000269|PubMed 26041762}. 
# GO_component	GO:0005813	centrosome; IDA:HPA.
# GO_component	GO:0005815	microtubule organizing center; IDA:HPA.
# GO_component	GO:0005882	intermediate filament; ISS:UniProtKB.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IC:UniProtKB.
# GO_component	GO:0009986	cell surface; IDA:UniProtKB.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0030425	dendrite; IEA:Ensembl.
# GO_component	GO:0042470	melanosome; IEA:UniProtKB-SubCell.
# GO_component	GO:0043025	neuronal cell body; IEA:Ensembl.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005254	chloride channel activity; IDA:UniProtKB.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015180	L-alanine transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015184	L-cystine transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015186	L-glutamine transmembrane transporter activity; TAS:BHF-UCL.
# GO_function	GO:0015193	L-proline transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015194	L-serine transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015195	L-threonine transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_function	GO:0034590	L-hydroxyproline transmembrane transporter activity; IDA:UniProtKB.
# GO_process	GO:0006865	amino acid transport; TAS:Reactome.
# GO_process	GO:0006868	glutamine transport; TAS:BHF-UCL.
# GO_process	GO:0015808	L-alanine transport; IDA:UniProtKB.
# GO_process	GO:0015811	L-cystine transport; IDA:UniProtKB.
# GO_process	GO:0015824	proline transport; IDA:UniProtKB.
# GO_process	GO:0015825	L-serine transport; IDA:UniProtKB.
# GO_process	GO:0015826	threonine transport; IDA:UniProtKB.
# GO_process	GO:0034589	hydroxyproline transport; IDA:UniProtKB.
# GO_process	GO:0035249	synaptic transmission, glutamatergic; NAS:UniProtKB.
# GO_process	GO:0050890	cognition; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005815	microtubule organizing center
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0050877	neurological system process
# Gene3D	1.10.3860.10	-; 2.
# Genevisible	P43007	HS
# HGNC	HGNC:10942	SLC1A4
# InterPro	IPR001991	Na-dicarboxylate_symporter
# InterPro	IPR018107	Na-dicarboxylate_symporter_CS
# KEGG_Brite	ko02001	Solute carrier family
# MIM	600229	gene
# MIM	616657	phenotype
# Organism	SATT_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11958	PTHR11958
# PIR	I37188	I37188
# PIR	I55389	I55389
# PRINTS	PR00173	EDTRNSPORT
# PROSITE	PS00713	NA_DICARBOXYL_SYMP_1
# PROSITE	PS00714	NA_DICARBOXYL_SYMP_2
# Pfam	PF00375	SDF
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-352230	Amino acid transport across the plasma membrane
# RecName	SATT_HUMAN	Neutral amino acid transporter A
# RefSeq	NP_001180422	NM_001193493.1. [P43007-2]
# RefSeq	NP_003029	NM_003038.4. [P43007-1]
# SIMILARITY	Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A4 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	SATT_HUMAN	Membrane {ECO 0000269|PubMed 17081065}; Multi-pass membrane protein {ECO 0000269|PubMed 17081065}. Melanosome {ECO 0000269|PubMed 17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. 
# SUPFAM	SSF118215	SSF118215; 2
# TCDB	2.A.23.3:the dicarboxylate/amino acid	cation (na(+) or h(+)) symporter (daacs) family
# TISSUE SPECIFICITY	SATT_HUMAN	Expressed mostly in brain, muscle, and pancreas but detected in all tissues examined. 
# UCSC	uc010ypz	human. [P43007-1]
# eggNOG	COG1301	LUCA
# eggNOG	KOG3787	Eukaryota
BLAST	swissprot:SATT_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SATT_HUMAN
BioCyc	ZFISH:ENSG00000115902-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000115902-MONOMER
COXPRESdb	6509	http://coxpresdb.jp/data/gene/6509.shtml
CleanEx	HS_SLC1A4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC1A4
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/geno.1994.1577	http://dx.doi.org/10.1006/geno.1994.1577
DOI	10.1021/pr060363j	http://dx.doi.org/10.1021/pr060363j
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/nbt.1532	http://dx.doi.org/10.1038/nbt.1532
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/cge.12605	http://dx.doi.org/10.1111/cge.12605
DOI	10.1111/cge.12637	http://dx.doi.org/10.1111/cge.12637
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1136/jmedgenet-2015-103104	http://dx.doi.org/10.1136/jmedgenet-2015-103104
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DrugBank	DB00160	http://www.drugbank.ca/drugs/DB00160
EMBL	AC007386	http://www.ebi.ac.uk/ena/data/view/AC007386
EMBL	AK295687	http://www.ebi.ac.uk/ena/data/view/AK295687
EMBL	BC026216	http://www.ebi.ac.uk/ena/data/view/BC026216
EMBL	BC072423	http://www.ebi.ac.uk/ena/data/view/BC072423
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
EMBL	L14595	http://www.ebi.ac.uk/ena/data/view/L14595
EMBL	L19444	http://www.ebi.ac.uk/ena/data/view/L19444
EMBL	U05229	http://www.ebi.ac.uk/ena/data/view/U05229
EMBL	U05230	http://www.ebi.ac.uk/ena/data/view/U05230
EMBL	U05231	http://www.ebi.ac.uk/ena/data/view/U05231
EMBL	U05232	http://www.ebi.ac.uk/ena/data/view/U05232
EMBL	U05233	http://www.ebi.ac.uk/ena/data/view/U05233
EMBL	U05234	http://www.ebi.ac.uk/ena/data/view/U05234
EMBL	U05235	http://www.ebi.ac.uk/ena/data/view/U05235
Ensembl	ENST00000234256	http://www.ensembl.org/id/ENST00000234256
Ensembl	ENST00000531327	http://www.ensembl.org/id/ENST00000531327
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005813
GO_component	GO:0005815	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005815
GO_component	GO:0005882	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005882
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0042470	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042470
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_function	GO:0015180	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015180
GO_function	GO:0015184	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015184
GO_function	GO:0015186	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015186
GO_function	GO:0015193	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015193
GO_function	GO:0015194	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015194
GO_function	GO:0015195	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015195
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_function	GO:0034590	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034590
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GO_process	GO:0006868	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006868
GO_process	GO:0015808	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015808
GO_process	GO:0015811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015811
GO_process	GO:0015824	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015824
GO_process	GO:0015825	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015825
GO_process	GO:0015826	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015826
GO_process	GO:0034589	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034589
GO_process	GO:0035249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035249
GO_process	GO:0050890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050890
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005815	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005815
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
Gene3D	1.10.3860.10	http://www.cathdb.info/version/latest/superfamily/1.10.3860.10
GeneCards	SLC1A4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC1A4
GeneID	6509	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6509
GeneTree	ENSGT00760000119117	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119117
HGNC	HGNC:10942	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10942
HOGENOM	HOG000208776	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000208776&db=HOGENOM6
HOVERGEN	HBG000080	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000080&db=HOVERGEN
HPA	HPA034963	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA034963
HPA	HPA034964	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA034964
InParanoid	P43007	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P43007
IntAct	P43007	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P43007*
InterPro	IPR001991	http://www.ebi.ac.uk/interpro/entry/IPR001991
InterPro	IPR018107	http://www.ebi.ac.uk/interpro/entry/IPR018107
Jabion	6509	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6509
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6509	http://www.genome.jp/dbget-bin/www_bget?hsa:6509
KEGG_Orthology	KO:K05615	http://www.genome.jp/dbget-bin/www_bget?KO:K05615
MIM	600229	http://www.ncbi.nlm.nih.gov/omim/600229
MIM	616657	http://www.ncbi.nlm.nih.gov/omim/616657
MINT	MINT-4656683	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4656683
OMA	CMAAVFI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CMAAVFI
OrthoDB	EOG091G0UCE	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0UCE
PANTHER	PTHR11958	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11958
PRINTS	PR00173	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00173
PROSITE	PS00713	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00713
PROSITE	PS00714	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00714
PSORT	swissprot:SATT_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SATT_HUMAN
PSORT-B	swissprot:SATT_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SATT_HUMAN
PSORT2	swissprot:SATT_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SATT_HUMAN
Pfam	PF00375	http://pfam.xfam.org/family/PF00375
PharmGKB	PA35829	http://www.pharmgkb.org/do/serve?objId=PA35829&objCls=Gene
Phobius	swissprot:SATT_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SATT_HUMAN
PhylomeDB	P43007	http://phylomedb.org/?seqid=P43007
ProteinModelPortal	P43007	http://www.proteinmodelportal.org/query/uniprot/P43007
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	17081065	http://www.ncbi.nlm.nih.gov/pubmed/17081065
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19349973	http://www.ncbi.nlm.nih.gov/pubmed/19349973
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	25930971	http://www.ncbi.nlm.nih.gov/pubmed/25930971
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	26041762	http://www.ncbi.nlm.nih.gov/pubmed/26041762
PubMed	26138499	http://www.ncbi.nlm.nih.gov/pubmed/26138499
PubMed	7896285	http://www.ncbi.nlm.nih.gov/pubmed/7896285
PubMed	8101838	http://www.ncbi.nlm.nih.gov/pubmed/8101838
PubMed	8340364	http://www.ncbi.nlm.nih.gov/pubmed/8340364
Reactome	R-HSA-352230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-352230
RefSeq	NP_001180422	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001180422
RefSeq	NP_003029	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003029
STRING	9606.ENSP00000234256	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000234256&targetmode=cogs
SUPFAM	SSF118215	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF118215
TCDB	2.A.23.3	http://www.tcdb.org/search/result.php?tc=2.A.23.3
UCSC	uc010ypz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010ypz&org=rat
UniGene	Hs.654352	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.654352
UniProtKB	SATT_HUMAN	http://www.uniprot.org/uniprot/SATT_HUMAN
UniProtKB-AC	P43007	http://www.uniprot.org/uniprot/P43007
charge	swissprot:SATT_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SATT_HUMAN
eggNOG	COG1301	http://eggnogapi.embl.de/nog_data/html/tree/COG1301
eggNOG	KOG3787	http://eggnogapi.embl.de/nog_data/html/tree/KOG3787
epestfind	swissprot:SATT_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SATT_HUMAN
garnier	swissprot:SATT_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SATT_HUMAN
helixturnhelix	swissprot:SATT_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SATT_HUMAN
hmoment	swissprot:SATT_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SATT_HUMAN
iep	swissprot:SATT_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SATT_HUMAN
inforesidue	swissprot:SATT_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SATT_HUMAN
neXtProt	NX_P43007	http://www.nextprot.org/db/entry/NX_P43007
octanol	swissprot:SATT_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SATT_HUMAN
pepcoil	swissprot:SATT_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SATT_HUMAN
pepdigest	swissprot:SATT_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SATT_HUMAN
pepinfo	swissprot:SATT_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SATT_HUMAN
pepnet	swissprot:SATT_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SATT_HUMAN
pepstats	swissprot:SATT_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SATT_HUMAN
pepwheel	swissprot:SATT_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SATT_HUMAN
pepwindow	swissprot:SATT_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SATT_HUMAN
sigcleave	swissprot:SATT_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SATT_HUMAN
## Database	ID	URL or Descriptions
# AltName	IMA5_HUMAN	Karyopherin subunit alpha-1
# AltName	IMA5_HUMAN	Nucleoprotein interactor 1
# AltName	IMA5_HUMAN	RAG cohort protein 2
# AltName	IMA5_HUMAN	SRP1-beta
# AltName	IMA5_HUMAN	SRP1-beta
# BioGrid	110034	108
# ChiTaRS	KPNA1	human
# DOMAIN	IMA5_HUMAN	Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import. {ECO 0000269|PubMed 8692858}. 
# DOMAIN	IMA5_HUMAN	The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS- containing proteins (By similarity). {ECO 0000250}. 
# DOMAIN	IMA5_HUMAN	The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity). {ECO 0000250}. 
# Ensembl	ENST00000344337	ENSP00000343701; ENSG00000114030
# ExpressionAtlas	P52294	baseline and differential
# FUNCTION	IMA5_HUMAN	Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS. 
# GO_component	GO:0005634	nucleus; ISS:UniProtKB.
# GO_component	GO:0005643	nuclear pore; TAS:ProtInc.
# GO_component	GO:0005654	nucleoplasm; IDA:HPA.
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0005829	cytosol; IBA:GO_Central.
# GO_component	GO:0030425	dendrite; ISS:UniProtKB.
# GO_function	GO:0008139	nuclear localization sequence binding; TAS:ProtInc.
# GO_function	GO:0008565	protein transporter activity; IBA:GO_Central.
# GO_process	GO:0000018	regulation of DNA recombination; TAS:ProtInc.
# GO_process	GO:0006309	apoptotic DNA fragmentation; TAS:Reactome.
# GO_process	GO:0006607	NLS-bearing protein import into nucleus; TAS:ProtInc.
# GO_process	GO:0019054	modulation by virus of host process; TAS:Reactome.
# GO_process	GO:0075733	intracellular transport of virus; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006259	DNA metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0034655	nucleobase-containing compound catabolic process
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# Gene3D	1.25.10.10	-; 1.
# Genevisible	P52294	HS
# HGNC	HGNC:6394	KPNA1
# INTERACTION	IMA5_HUMAN	Q9WMX2 - (xeno); NbExp=2; IntAct=EBI-358383, EBI-6863741; Q92688 ANP32B; NbExp=7; IntAct=EBI-358383, EBI-762428; Q9HAZ1 CLK4; NbExp=3; IntAct=EBI-358383, EBI-633400; Q5TAQ9 DCAF8; NbExp=2; IntAct=EBI-358383, EBI-740686; Q13255 GRM1; NbExp=2; IntAct=EBI-358383, EBI-8527352; P20700 LMNB1; NbExp=3; IntAct=EBI-358383, EBI-968218; Q9UKX7 NUP50; NbExp=6; IntAct=EBI-358383, EBI-2371082; B4URF7 PB2 (xeno); NbExp=2; IntAct=EBI-358383, EBI-6050648; Q15637 SF1; NbExp=3; IntAct=EBI-358383, EBI-744603; Q16594 TAF9; NbExp=4; IntAct=EBI-358383, EBI-712521; 
# IntAct	P52294	73
# InterPro	IPR000225	Armadillo
# InterPro	IPR002652	Importin-a_IBB
# InterPro	IPR011989	ARM-like
# InterPro	IPR016024	ARM-type_fold
# InterPro	IPR024931	Importing_su_alpha
# InterPro	IPR032413	Arm_3
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko03036	 Chromosome
# KEGG_Pathway	ko05164	Influenza A
# MIM	600686	gene
# Organism	IMA5_HUMAN	Homo sapiens (Human)
# PDB	2JDQ	X-ray; 2.20 A; A/B=66-512
# PDB	3TJ3	X-ray; 2.70 A; A/B=66-512
# PDB	4B18	X-ray; 2.52 A; A=66-512
# PIR	I59931	I59931
# PIRSF	PIRSF005673	Importin_alpha
# PROSITE	PS50176	ARM_REPEAT; 4
# PROSITE	PS51214	IBB
# PTM	IMA5_HUMAN	Polyubiquitinated in the presence of RAG1 (in vitro). {ECO 0000269|PubMed 19118899}. 
# Pfam	PF00514	Arm; 8
# Pfam	PF01749	IBB
# Pfam	PF16186	Arm_3
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-1169408	ISG15 antiviral mechanism
# Reactome	R-HSA-162592	Integration of provirus
# Reactome	R-HSA-168271	Transport of Ribonucleoproteins into the Host Nucleus
# Reactome	R-HSA-168276	NS1 Mediated Effects on Host Pathways
# Reactome	R-HSA-180910	Vpr-mediated nuclear import of PICs
# Reactome	R-HSA-211227	Activation of DNA fragmentation factor
# RecName	IMA5_HUMAN	Importin subunit alpha-5
# RecName	IMA5_HUMAN	Importin subunit alpha-5, N-terminally processed
# RefSeq	NP_002255	NM_002264.3
# RefSeq	XP_005247494	XM_005247437.3
# SIMILARITY	Belongs to the importin alpha family. {ECO	0000305}. 
# SIMILARITY	Contains 1 IBB domain. {ECO:0000255|PROSITE- ProRule	PRU00561}.
# SIMILARITY	Contains 10 ARM repeats. {ECO:0000255|PROSITE- ProRule	PRU00259}. 
# SMART	SM00185	ARM; 8
# SUBCELLULAR LOCATION	IMA5_HUMAN	Cytoplasm {ECO 0000269|PubMed 7604027}. Nucleus {ECO 0000269|PubMed 7604027}. 
# SUBUNIT	IMA5_HUMAN	Heterodimer; with KPNB1. Interacts with ANP32E. Interacts with ZIC3 (By similarity). Interacts with NSMF; the interaction occurs in a calcium-independent manner after synaptic NMDA receptor stimulation and is required for nuclear import of NSMF but is competed by CABP1 (By similarity). Interacts with the nucleoprotein of influenza A viruses. Binds to HCMV (human cytomegalovirus) UL84, HIV-1 Vpr and to ebolavirus VP24. Interacts with APEX1 and RAG1. Interacts with CTNNBL1 (via its N-terminal). Interacts with AICDA (via its NLS). Interacts with SNAI1 (via zinc fingers). Interacts with DCAF8. {ECO 0000250, ECO 0000269|PubMed 12610148, ECO 0000269|PubMed 15942031, ECO 0000269|PubMed 16698996, ECO 0000269|PubMed 21385873, ECO 0000269|PubMed 21454664, ECO 0000269|PubMed 22500989, ECO 0000269|PubMed 7604027, ECO 0000269|PubMed 8052633, ECO 0000269|PubMed 9463369}. 
# SUPFAM	SSF48371	SSF48371
# TCDB	1.I.1.1	the nuclear pore complex (npc) family
# TISSUE SPECIFICITY	IMA5_HUMAN	Expressed ubiquitously. 
# UCSC	uc003efe	human
# eggNOG	COG5064	LUCA
# eggNOG	KOG0166	Eukaryota
BLAST	swissprot:IMA5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:IMA5_HUMAN
BioCyc	ZFISH:ENSG00000114030-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000114030-MONOMER
COXPRESdb	3836	http://coxpresdb.jp/data/gene/3836.shtml
CleanEx	HS_KPNA1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KPNA1
DIP	DIP-29296N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29296N
DOI	10.1016/S0042-6822(95)80026-3	http://dx.doi.org/10.1016/S0042-6822(95)80026-3
DOI	10.1016/j.febslet.2012.02.053	http://dx.doi.org/10.1016/j.febslet.2012.02.053
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1016/j.molimm.2008.11.009	http://dx.doi.org/10.1016/j.molimm.2008.11.009
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1073/pnas.91.16.7633	http://dx.doi.org/10.1073/pnas.91.16.7633
DOI	10.1073/pnas.92.14.6532	http://dx.doi.org/10.1073/pnas.92.14.6532
DOI	10.1073/pnas.92.6.2008	http://dx.doi.org/10.1073/pnas.92.6.2008
DOI	10.1073/pnas.93.13.6572	http://dx.doi.org/10.1073/pnas.93.13.6572
DOI	10.1074/jbc.M110.208769	http://dx.doi.org/10.1074/jbc.M110.208769
DOI	10.1074/jbc.M110.213579	http://dx.doi.org/10.1074/jbc.M110.213579
DOI	10.1093/emboj/17.4.909	http://dx.doi.org/10.1093/emboj/17.4.909
DOI	10.1093/nar/gki641	http://dx.doi.org/10.1093/nar/gki641
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1128/JVI.02349-05	http://dx.doi.org/10.1128/JVI.02349-05
DOI	10.1128/JVI.77.6.3734-3748.2003	http://dx.doi.org/10.1128/JVI.77.6.3734-3748.2003
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AC083798	http://www.ebi.ac.uk/ena/data/view/AC083798
EMBL	AC096861	http://www.ebi.ac.uk/ena/data/view/AC096861
EMBL	BC002374	http://www.ebi.ac.uk/ena/data/view/BC002374
EMBL	BC003009	http://www.ebi.ac.uk/ena/data/view/BC003009
EMBL	BT006959	http://www.ebi.ac.uk/ena/data/view/BT006959
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
EMBL	CR456743	http://www.ebi.ac.uk/ena/data/view/CR456743
EMBL	S75295	http://www.ebi.ac.uk/ena/data/view/S75295
Ensembl	ENST00000344337	http://www.ensembl.org/id/ENST00000344337
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005643	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005643
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_function	GO:0008139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008139
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0000018	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000018
GO_process	GO:0006309	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006309
GO_process	GO:0006607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006607
GO_process	GO:0019054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019054
GO_process	GO:0075733	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0075733
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006259	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0034655	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
GeneCards	KPNA1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KPNA1
GeneID	3836	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3836
GeneTree	ENSGT00760000119094	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119094
HGNC	HGNC:6394	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6394
HOGENOM	HOG000167616	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000167616&db=HOGENOM6
HOVERGEN	HBG001846	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG001846&db=HOVERGEN
HPA	HPA053627	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA053627
HPA	HPA063426	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA063426
InParanoid	P52294	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52294
IntAct	P52294	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52294*
InterPro	IPR000225	http://www.ebi.ac.uk/interpro/entry/IPR000225
InterPro	IPR002652	http://www.ebi.ac.uk/interpro/entry/IPR002652
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
InterPro	IPR024931	http://www.ebi.ac.uk/interpro/entry/IPR024931
InterPro	IPR032413	http://www.ebi.ac.uk/interpro/entry/IPR032413
Jabion	3836	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3836
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko03036	http://www.genome.jp/dbget-bin/www_bget?ko03036
KEGG_Gene	hsa:3836	http://www.genome.jp/dbget-bin/www_bget?hsa:3836
KEGG_Orthology	KO:K15042	http://www.genome.jp/dbget-bin/www_bget?KO:K15042
KEGG_Pathway	ko05164	http://www.genome.jp/kegg-bin/show_pathway?ko05164
MIM	600686	http://www.ncbi.nlm.nih.gov/omim/600686
MINT	MINT-240027	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-240027
OMA	WNCESES	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WNCESES
OrthoDB	EOG091G095Z	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G095Z
PDB	2JDQ	http://www.ebi.ac.uk/pdbe-srv/view/entry/2JDQ
PDB	3TJ3	http://www.ebi.ac.uk/pdbe-srv/view/entry/3TJ3
PDB	4B18	http://www.ebi.ac.uk/pdbe-srv/view/entry/4B18
PDBsum	2JDQ	http://www.ebi.ac.uk/pdbsum/2JDQ
PDBsum	3TJ3	http://www.ebi.ac.uk/pdbsum/3TJ3
PDBsum	4B18	http://www.ebi.ac.uk/pdbsum/4B18
PROSITE	PS50176	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50176
PROSITE	PS51214	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51214
PSORT	swissprot:IMA5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:IMA5_HUMAN
PSORT-B	swissprot:IMA5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:IMA5_HUMAN
PSORT2	swissprot:IMA5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:IMA5_HUMAN
Pfam	PF00514	http://pfam.xfam.org/family/PF00514
Pfam	PF01749	http://pfam.xfam.org/family/PF01749
Pfam	PF16186	http://pfam.xfam.org/family/PF16186
PharmGKB	PA30185	http://www.pharmgkb.org/do/serve?objId=PA30185&objCls=Gene
Phobius	swissprot:IMA5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:IMA5_HUMAN
PhylomeDB	P52294	http://phylomedb.org/?seqid=P52294
ProteinModelPortal	P52294	http://www.proteinmodelportal.org/query/uniprot/P52294
PubMed	12610148	http://www.ncbi.nlm.nih.gov/pubmed/12610148
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15942031	http://www.ncbi.nlm.nih.gov/pubmed/15942031
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	16698996	http://www.ncbi.nlm.nih.gov/pubmed/16698996
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	19118899	http://www.ncbi.nlm.nih.gov/pubmed/19118899
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21385873	http://www.ncbi.nlm.nih.gov/pubmed/21385873
PubMed	21454664	http://www.ncbi.nlm.nih.gov/pubmed/21454664
PubMed	22500989	http://www.ncbi.nlm.nih.gov/pubmed/22500989
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	7604027	http://www.ncbi.nlm.nih.gov/pubmed/7604027
PubMed	7831767	http://www.ncbi.nlm.nih.gov/pubmed/7831767
PubMed	7892216	http://www.ncbi.nlm.nih.gov/pubmed/7892216
PubMed	8052633	http://www.ncbi.nlm.nih.gov/pubmed/8052633
PubMed	8692858	http://www.ncbi.nlm.nih.gov/pubmed/8692858
PubMed	9463369	http://www.ncbi.nlm.nih.gov/pubmed/9463369
Reactome	R-HSA-1169408	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1169408
Reactome	R-HSA-162592	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-162592
Reactome	R-HSA-168271	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-168271
Reactome	R-HSA-168276	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-168276
Reactome	R-HSA-180910	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-180910
Reactome	R-HSA-211227	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-211227
RefSeq	NP_002255	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002255
RefSeq	XP_005247494	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005247494
SMART	SM00185	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00185
SMR	P52294	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52294
STRING	9606.ENSP00000343701	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000343701&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
TCDB	1.I.1.1	http://www.tcdb.org/search/result.php?tc=1.I.1.1
UCSC	uc003efe	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003efe&org=rat
UniGene	Hs.161008	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.161008
UniProtKB	IMA5_HUMAN	http://www.uniprot.org/uniprot/IMA5_HUMAN
UniProtKB-AC	P52294	http://www.uniprot.org/uniprot/P52294
charge	swissprot:IMA5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:IMA5_HUMAN
eggNOG	COG5064	http://eggnogapi.embl.de/nog_data/html/tree/COG5064
eggNOG	KOG0166	http://eggnogapi.embl.de/nog_data/html/tree/KOG0166
epestfind	swissprot:IMA5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:IMA5_HUMAN
garnier	swissprot:IMA5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:IMA5_HUMAN
helixturnhelix	swissprot:IMA5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:IMA5_HUMAN
hmoment	swissprot:IMA5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:IMA5_HUMAN
iep	swissprot:IMA5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:IMA5_HUMAN
inforesidue	swissprot:IMA5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:IMA5_HUMAN
neXtProt	NX_P52294	http://www.nextprot.org/db/entry/NX_P52294
octanol	swissprot:IMA5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:IMA5_HUMAN
pepcoil	swissprot:IMA5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:IMA5_HUMAN
pepdigest	swissprot:IMA5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:IMA5_HUMAN
pepinfo	swissprot:IMA5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:IMA5_HUMAN
pepnet	swissprot:IMA5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:IMA5_HUMAN
pepstats	swissprot:IMA5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:IMA5_HUMAN
pepwheel	swissprot:IMA5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:IMA5_HUMAN
pepwindow	swissprot:IMA5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:IMA5_HUMAN
sigcleave	swissprot:IMA5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:IMA5_HUMAN
## Database	ID	URL or Descriptions
# AltName	S35E3_HUMAN	Bladder cancer-overexpressed gene 1 protein
# ChiTaRS	SLC35E3	human
# Ensembl	ENST00000398004	ENSP00000381089; ENSG00000175782
# ExpressionAtlas	Q7Z769	baseline and differential
# FUNCTION	S35E3_HUMAN	Putative transporter. {ECO 0000250}. 
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005338	nucleotide-sugar transmembrane transporter activity; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# Genevisible	Q7Z769	HS
# HGNC	HGNC:20864	SLC35E3
# InterPro	IPR004853	Sugar_P_trans_dom
# KEGG_Brite	ko02001	Solute carrier family
# Organism	S35E3_HUMAN	Homo sapiens (Human)
# Pfam	PF03151	TPT
# Proteomes	UP000005640	Chromosome 12
# RecName	S35E3_HUMAN	Solute carrier family 35 member E3
# RefSeq	NP_061126	NM_018656.2
# SEQUENCE CAUTION	Sequence=AAF73127.1; Type=Frameshift; Positions=4, 16, 40; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the TPT transporter family. SLC35E subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S35E3_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	2.A.7.9.15	the drug/metabolite transporter (dmt) superfamily
# UCSC	uc001suh	human
# eggNOG	ENOG410XP1S	LUCA
# eggNOG	KOG1441	Eukaryota
BLAST	swissprot:S35E3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S35E3_HUMAN
COXPRESdb	55508	http://coxpresdb.jp/data/gene/55508.shtml
CleanEx	HS_SLC35E3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC35E3
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF148713	http://www.ebi.ac.uk/ena/data/view/AF148713
EMBL	AK289645	http://www.ebi.ac.uk/ena/data/view/AK289645
EMBL	AY358943	http://www.ebi.ac.uk/ena/data/view/AY358943
EMBL	BC008412	http://www.ebi.ac.uk/ena/data/view/BC008412
EMBL	BC021103	http://www.ebi.ac.uk/ena/data/view/BC021103
EMBL	BC030504	http://www.ebi.ac.uk/ena/data/view/BC030504
EMBL	BC049192	http://www.ebi.ac.uk/ena/data/view/BC049192
EMBL	CH471054	http://www.ebi.ac.uk/ena/data/view/CH471054
Ensembl	ENST00000398004	http://www.ensembl.org/id/ENST00000398004
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005338	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005338
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GeneCards	SLC35E3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC35E3
GeneID	55508	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55508
GeneTree	ENSGT00730000111164	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00730000111164
HGNC	HGNC:20864	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20864
HOGENOM	HOG000242404	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000242404&db=HOGENOM6
HOVERGEN	HBG059041	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG059041&db=HOVERGEN
HPA	HPA049403	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA049403
InParanoid	Q7Z769	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q7Z769
InterPro	IPR004853	http://www.ebi.ac.uk/interpro/entry/IPR004853
Jabion	55508	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55508
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:55508	http://www.genome.jp/dbget-bin/www_bget?hsa:55508
KEGG_Orthology	KO:K15285	http://www.genome.jp/dbget-bin/www_bget?KO:K15285
OMA	DVKFNVL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DVKFNVL
OrthoDB	EOG091G0I3C	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0I3C
PSORT	swissprot:S35E3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S35E3_HUMAN
PSORT-B	swissprot:S35E3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S35E3_HUMAN
PSORT2	swissprot:S35E3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S35E3_HUMAN
Pfam	PF03151	http://pfam.xfam.org/family/PF03151
PharmGKB	PA128394684	http://www.pharmgkb.org/do/serve?objId=PA128394684&objCls=Gene
Phobius	swissprot:S35E3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S35E3_HUMAN
PhylomeDB	Q7Z769	http://phylomedb.org/?seqid=Q7Z769
ProteinModelPortal	Q7Z769	http://www.proteinmodelportal.org/query/uniprot/Q7Z769
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
RefSeq	NP_061126	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061126
STRING	9606.ENSP00000381089	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000381089&targetmode=cogs
TCDB	2.A.7.9.15	http://www.tcdb.org/search/result.php?tc=2.A.7.9.15
UCSC	uc001suh	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001suh&org=rat
UniGene	Hs.506011	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.506011
UniProtKB	S35E3_HUMAN	http://www.uniprot.org/uniprot/S35E3_HUMAN
UniProtKB-AC	Q7Z769	http://www.uniprot.org/uniprot/Q7Z769
charge	swissprot:S35E3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S35E3_HUMAN
eggNOG	ENOG410XP1S	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XP1S
eggNOG	KOG1441	http://eggnogapi.embl.de/nog_data/html/tree/KOG1441
epestfind	swissprot:S35E3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S35E3_HUMAN
garnier	swissprot:S35E3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S35E3_HUMAN
helixturnhelix	swissprot:S35E3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S35E3_HUMAN
hmoment	swissprot:S35E3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S35E3_HUMAN
iep	swissprot:S35E3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S35E3_HUMAN
inforesidue	swissprot:S35E3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S35E3_HUMAN
neXtProt	NX_Q7Z769	http://www.nextprot.org/db/entry/NX_Q7Z769
octanol	swissprot:S35E3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S35E3_HUMAN
pepcoil	swissprot:S35E3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S35E3_HUMAN
pepdigest	swissprot:S35E3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S35E3_HUMAN
pepinfo	swissprot:S35E3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S35E3_HUMAN
pepnet	swissprot:S35E3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S35E3_HUMAN
pepstats	swissprot:S35E3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S35E3_HUMAN
pepwheel	swissprot:S35E3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S35E3_HUMAN
pepwindow	swissprot:S35E3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S35E3_HUMAN
sigcleave	swissprot:S35E3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S35E3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SO5A1_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9H2Y9-1; Sequence=Displayed; Name=2; IsoId=Q9H2Y9-2; Sequence=VSP_045498; Note=No experimental confirmation available.; Name=3; IsoId=Q9H2Y9-3; Sequence=VSP_045499, VSP_045500; Note=No experimental confirmation available.; 
# AltName	SO5A1_HUMAN	Organic anion transporter polypeptide-related protein 4
# AltName	SO5A1_HUMAN	Solute carrier family 21 member 15
# CCDS	CCDS55242	-. [Q9H2Y9-2]
# CCDS	CCDS55243	-. [Q9H2Y9-3]
# CCDS	CCDS6205	-. [Q9H2Y9-1]
# CDD	cd06174	MFS
# Ensembl	ENST00000260126	ENSP00000260126; ENSG00000137571. [Q9H2Y9-1]
# Ensembl	ENST00000524945	ENSP00000434422; ENSG00000137571. [Q9H2Y9-3]
# Ensembl	ENST00000530307	ENSP00000431611; ENSG00000137571. [Q9H2Y9-2]
# ExpressionAtlas	Q9H2Y9	baseline and differential
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0015347	sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0043252	sodium-independent organic anion transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q9H2Y9	HS
# HGNC	HGNC:19046	SLCO5A1
# InterPro	IPR002350	Kazal_dom
# InterPro	IPR004156	OA_transporter
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02001	Solute carrier family
# MIM	613543	gene
# Organism	SO5A1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11388	PTHR11388; 2
# PROSITE	PS50850	MFS
# PROSITE	PS51465	KAZAL_2
# Pfam	PF03137	OATP
# Pfam	PF07648	Kazal_2
# Proteomes	UP000005640	Chromosome 8
# RecName	SO5A1_HUMAN	Solute carrier organic anion transporter family member 5A1
# RefSeq	NP_001139480	NM_001146008.1. [Q9H2Y9-3]
# RefSeq	NP_001139481	NM_001146009.1. [Q9H2Y9-2]
# RefSeq	NP_112220	NM_030958.2. [Q9H2Y9-1]
# RefSeq	XP_005251370	XM_005251313.2. [Q9H2Y9-2]
# RefSeq	XP_016869372	XM_017013883.1. [Q9H2Y9-3]
# SIMILARITY	Belongs to the organo anion transporter (TC 2.A.60) family. {ECO	0000305}. 
# SIMILARITY	Contains 1 Kazal-like domain. {ECO:0000255|PROSITE- ProRule	PRU00798}.
# SUBCELLULAR LOCATION	SO5A1_HUMAN	Cell membrane; Multi-pass membrane protein. 
# SUPFAM	SSF103473	SSF103473; 4
# TCDB	2.A.60.1.16	the organo anion transporter (oat) family
# TIGRFAMs	TIGR00805	oat
# UCSC	uc003xyk	human. [Q9H2Y9-1]
# eggNOG	ENOG410XRSF	LUCA
# eggNOG	KOG3626	Eukaryota
BLAST	swissprot:SO5A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SO5A1_HUMAN
BioCyc	ZFISH:ENSG00000137571-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000137571-MONOMER
COXPRESdb	81796	http://coxpresdb.jp/data/gene/81796.shtml
CleanEx	HS_SLCO5A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLCO5A1
DOI	10.1038/nature04406	http://dx.doi.org/10.1038/nature04406
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC024680	http://www.ebi.ac.uk/ena/data/view/AC024680
EMBL	AC079089	http://www.ebi.ac.uk/ena/data/view/AC079089
EMBL	AC091047	http://www.ebi.ac.uk/ena/data/view/AC091047
EMBL	AF205075	http://www.ebi.ac.uk/ena/data/view/AF205075
EMBL	AK022760	http://www.ebi.ac.uk/ena/data/view/AK022760
EMBL	BC137424	http://www.ebi.ac.uk/ena/data/view/BC137424
EMBL	BC139755	http://www.ebi.ac.uk/ena/data/view/BC139755
EMBL	CH471068	http://www.ebi.ac.uk/ena/data/view/CH471068
EMBL	CH471068	http://www.ebi.ac.uk/ena/data/view/CH471068
Ensembl	ENST00000260126	http://www.ensembl.org/id/ENST00000260126
Ensembl	ENST00000524945	http://www.ensembl.org/id/ENST00000524945
Ensembl	ENST00000530307	http://www.ensembl.org/id/ENST00000530307
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0015347	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015347
GO_process	GO:0043252	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043252
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLCO5A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLCO5A1
GeneID	81796	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81796
GeneTree	ENSGT00760000119014	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119014
HGNC	HGNC:19046	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:19046
HOGENOM	HOG000060097	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000060097&db=HOGENOM6
HOVERGEN	HBG069241	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG069241&db=HOVERGEN
HPA	HPA025062	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA025062
InParanoid	Q9H2Y9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9H2Y9
IntAct	Q9H2Y9	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9H2Y9*
InterPro	IPR002350	http://www.ebi.ac.uk/interpro/entry/IPR002350
InterPro	IPR004156	http://www.ebi.ac.uk/interpro/entry/IPR004156
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	81796	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=81796
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:81796	http://www.genome.jp/dbget-bin/www_bget?hsa:81796
KEGG_Orthology	KO:K14356	http://www.genome.jp/dbget-bin/www_bget?KO:K14356
MIM	613543	http://www.ncbi.nlm.nih.gov/omim/613543
OMA	CFDIGNL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CFDIGNL
OrthoDB	EOG091G02FX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02FX
PANTHER	PTHR11388	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11388
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PROSITE	PS51465	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51465
PSORT	swissprot:SO5A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SO5A1_HUMAN
PSORT-B	swissprot:SO5A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SO5A1_HUMAN
PSORT2	swissprot:SO5A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SO5A1_HUMAN
Pfam	PF03137	http://pfam.xfam.org/family/PF03137
Pfam	PF07648	http://pfam.xfam.org/family/PF07648
PharmGKB	PA134948571	http://www.pharmgkb.org/do/serve?objId=PA134948571&objCls=Gene
Phobius	swissprot:SO5A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SO5A1_HUMAN
PhylomeDB	Q9H2Y9	http://phylomedb.org/?seqid=Q9H2Y9
ProteinModelPortal	Q9H2Y9	http://www.proteinmodelportal.org/query/uniprot/Q9H2Y9
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16421571	http://www.ncbi.nlm.nih.gov/pubmed/16421571
RefSeq	NP_001139480	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001139480
RefSeq	NP_001139481	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001139481
RefSeq	NP_112220	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_112220
RefSeq	XP_005251370	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005251370
RefSeq	XP_016869372	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016869372
STRING	9606.ENSP00000260126	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000260126&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.60.1.16	http://www.tcdb.org/search/result.php?tc=2.A.60.1.16
TIGRFAMs	TIGR00805	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00805
UCSC	uc003xyk	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003xyk&org=rat
UniGene	Hs.152460	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.152460
UniGene	Hs.443609	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.443609
UniProtKB	SO5A1_HUMAN	http://www.uniprot.org/uniprot/SO5A1_HUMAN
UniProtKB-AC	Q9H2Y9	http://www.uniprot.org/uniprot/Q9H2Y9
charge	swissprot:SO5A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SO5A1_HUMAN
eggNOG	ENOG410XRSF	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRSF
eggNOG	KOG3626	http://eggnogapi.embl.de/nog_data/html/tree/KOG3626
epestfind	swissprot:SO5A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SO5A1_HUMAN
garnier	swissprot:SO5A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SO5A1_HUMAN
helixturnhelix	swissprot:SO5A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SO5A1_HUMAN
hmoment	swissprot:SO5A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SO5A1_HUMAN
iep	swissprot:SO5A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SO5A1_HUMAN
inforesidue	swissprot:SO5A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SO5A1_HUMAN
neXtProt	NX_Q9H2Y9	http://www.nextprot.org/db/entry/NX_Q9H2Y9
octanol	swissprot:SO5A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SO5A1_HUMAN
pepcoil	swissprot:SO5A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SO5A1_HUMAN
pepdigest	swissprot:SO5A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SO5A1_HUMAN
pepinfo	swissprot:SO5A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SO5A1_HUMAN
pepnet	swissprot:SO5A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SO5A1_HUMAN
pepstats	swissprot:SO5A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SO5A1_HUMAN
pepwheel	swissprot:SO5A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SO5A1_HUMAN
pepwindow	swissprot:SO5A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SO5A1_HUMAN
sigcleave	swissprot:SO5A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SO5A1_HUMAN
## Database	ID	URL or Descriptions
# AltName	BAT1_HUMAN	Glycoprotein-associated amino acid transporter b0,+AT1
# AltName	BAT1_HUMAN	Solute carrier family 7 member 9
# BioGrid	116309	3
# DISEASE	BAT1_HUMAN	Cystinuria (CSNU) [MIM 220100]  An autosomal disorder characterized by impaired epithelial cell transport of cystine and dibasic amino acids (lysine, ornithine, and arginine) in the proximal renal tubule and gastrointestinal tract. The impaired renal reabsorption of cystine and its low solubility causes the formation of calculi in the urinary tract, resulting in obstructive uropathy, pyelonephritis, and, rarely, renal failure. {ECO 0000269|PubMed 10471498, ECO 0000269|PubMed 11157794, ECO 0000269|PubMed 12234283, ECO 0000269|PubMed 12371955, ECO 0000269|PubMed 12820697, ECO 0000269|PubMed 15635077, ECO 0000269|PubMed 16138908, ECO 0000269|PubMed 16609684, ECO 0000269|PubMed 18752446, ECO 0000269|PubMed 19782624}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00138	L-Cystine
# Ensembl	ENST00000023064	ENSP00000023064; ENSG00000021488
# Ensembl	ENST00000587772	ENSP00000468439; ENSG00000021488
# Ensembl	ENST00000590341	ENSP00000464822; ENSG00000021488
# ExpressionAtlas	P82251	baseline and differential
# FUNCTION	BAT1_HUMAN	Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high- affinity reabsorption of cystine in the kidney tubule. {ECO 0000269|PubMed 10471498, ECO 0000269|PubMed 10588648, ECO 0000269|PubMed 16609684}. 
# GO_component	GO:0005886	plasma membrane; ISS:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_component	GO:0031526	brush border membrane; IDA:UniProtKB.
# GO_function	GO:0015175	neutral amino acid transmembrane transporter activity; IMP:UniProtKB.
# GO_function	GO:0015184	L-cystine transmembrane transporter activity; IMP:UniProtKB.
# GO_function	GO:0015297	antiporter activity; IBA:GO_Central.
# GO_function	GO:0042605	peptide antigen binding; ISS:UniProtKB.
# GO_process	GO:0006461	protein complex assembly; TAS:ProtInc.
# GO_process	GO:0006865	amino acid transport; TAS:Reactome.
# GO_process	GO:0015804	neutral amino acid transport; IMP:UniProtKB.
# GO_process	GO:0015811	L-cystine transport; IMP:UniProtKB.
# GO_process	GO:0050900	leukocyte migration; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0048870	cell motility
# Genevisible	P82251	HS
# HGNC	HGNC:11067	SLC7A9
# IntAct	P82251	3
# InterPro	IPR002293	AA/rel_permease1
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H00901	[Inherited metabolic disease; Urinary system disease; Kidney disease] Cystinuria
# KEGG_Pathway	ko04974	Protein digestion and absorption
# MIM	220100	phenotype
# MIM	604144	gene
# Organism	BAT1_HUMAN	Homo sapiens (Human)
# Orphanet	93613	Cystinuria type B
# PANTHER	PTHR11785	PTHR11785
# PIRSF	PIRSF006060	AA_transporter
# Pfam	PF13520	AA_permease_2
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-210991	Basigin interactions
# Reactome	R-HSA-352230	Amino acid transport across the plasma membrane
# RecName	BAT1_HUMAN	b(0,+)-type amino acid transporter 1
# RefSeq	NP_001119807	NM_001126335.1
# RefSeq	NP_001229965	NM_001243036.1
# RefSeq	NP_055085	NM_014270.4
# RefSeq	XP_011524704	XM_011526402.2
# SIMILARITY	Belongs to the amino acid-polyamine-organocation (APC) superfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	BAT1_HUMAN	Apical cell membrane {ECO 0000269|PubMed 12167606, ECO 0000269|PubMed 16609684}; Multi- pass membrane protein {ECO 0000269|PubMed 16609684, ECO 0000305|PubMed 12167606}. 
# SUBUNIT	Disulfide-linked heterodimer with the amino acid transport protein SLC3A1. Interacts with CAV1. {ECO:0000250|UniProtKB	P82252}. 
# TCDB	2.A.3.8.19	the amino acid-polyamine-organocation (apc) family
# TISSUE SPECIFICITY	BAT1_HUMAN	Expressed in the brush border membrane in the kidney (at protein level). Kidney, small intestine, liver and placenta. {ECO 0000269|PubMed 10471498, ECO 0000269|PubMed 12167606}. 
# UCSC	uc002ntu	human
# eggNOG	COG0531	LUCA
# eggNOG	KOG1287	Eukaryota
BLAST	swissprot:BAT1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:BAT1_HUMAN
BioCyc	ZFISH:ENSG00000021488-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000021488-MONOMER
COXPRESdb	11136	http://coxpresdb.jp/data/gene/11136.shtml
CleanEx	HS_BAT1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_BAT1
CleanEx	HS_SLC7A9	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC7A9
DOI	10.1016/j.ymgme.2009.09.001	http://dx.doi.org/10.1016/j.ymgme.2009.09.001
DOI	10.1038/12652	http://dx.doi.org/10.1038/12652
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.ki.5000241	http://dx.doi.org/10.1038/sj.ki.5000241
DOI	10.1046/j.1523-1755.2001.0590051821.x	http://dx.doi.org/10.1046/j.1523-1755.2001.0590051821.x
DOI	10.1046/j.1523-1755.2002.00552.x	http://dx.doi.org/10.1046/j.1523-1755.2002.00552.x
DOI	10.1046/j.1523-1755.2002.00602.x	http://dx.doi.org/10.1046/j.1523-1755.2002.00602.x
DOI	10.1089/109065703321560886	http://dx.doi.org/10.1089/109065703321560886
DOI	10.1089/gte.2007.0113	http://dx.doi.org/10.1089/gte.2007.0113
DOI	10.1091/mbc.10.12.4135	http://dx.doi.org/10.1091/mbc.10.12.4135
DOI	10.1093/hmg/10.4.305	http://dx.doi.org/10.1093/hmg/10.4.305
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1529-8817.2005.00185.x	http://dx.doi.org/10.1111/j.1529-8817.2005.00185.x
DOI	10.1136/jmg.2004.022244	http://dx.doi.org/10.1136/jmg.2004.022244
DrugBank	DB00138	http://www.drugbank.ca/drugs/DB00138
EMBL	AB033548	http://www.ebi.ac.uk/ena/data/view/AB033548
EMBL	AF141289	http://www.ebi.ac.uk/ena/data/view/AF141289
EMBL	AF421170	http://www.ebi.ac.uk/ena/data/view/AF421170
EMBL	AF421171	http://www.ebi.ac.uk/ena/data/view/AF421171
EMBL	AF421172	http://www.ebi.ac.uk/ena/data/view/AF421172
EMBL	AF421173	http://www.ebi.ac.uk/ena/data/view/AF421173
EMBL	AF421174	http://www.ebi.ac.uk/ena/data/view/AF421174
EMBL	AF421175	http://www.ebi.ac.uk/ena/data/view/AF421175
EMBL	AF421176	http://www.ebi.ac.uk/ena/data/view/AF421176
EMBL	AF421177	http://www.ebi.ac.uk/ena/data/view/AF421177
EMBL	AF421178	http://www.ebi.ac.uk/ena/data/view/AF421178
EMBL	AF421179	http://www.ebi.ac.uk/ena/data/view/AF421179
EMBL	AF421180	http://www.ebi.ac.uk/ena/data/view/AF421180
EMBL	AF421181	http://www.ebi.ac.uk/ena/data/view/AF421181
EMBL	AJ249199	http://www.ebi.ac.uk/ena/data/view/AJ249199
EMBL	AK313708	http://www.ebi.ac.uk/ena/data/view/AK313708
EMBL	BC017962	http://www.ebi.ac.uk/ena/data/view/BC017962
Ensembl	ENST00000023064	http://www.ensembl.org/id/ENST00000023064
Ensembl	ENST00000587772	http://www.ensembl.org/id/ENST00000587772
Ensembl	ENST00000590341	http://www.ensembl.org/id/ENST00000590341
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0031526	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031526
GO_function	GO:0015175	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015175
GO_function	GO:0015184	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015184
GO_function	GO:0015297	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297
GO_function	GO:0042605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042605
GO_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GO_process	GO:0015804	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015804
GO_process	GO:0015811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015811
GO_process	GO:0050900	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050900
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GeneCards	SLC7A9	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC7A9
GeneID	11136	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11136
GeneTree	ENSGT00760000119037	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119037
HGNC	HGNC:11067	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11067
HOGENOM	HOG000098892	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000098892&db=HOGENOM6
HOVERGEN	HBG000476	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000476&db=HOVERGEN
HPA	HPA042591	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042591
InParanoid	P82251	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P82251
IntAct	P82251	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P82251*
InterPro	IPR002293	http://www.ebi.ac.uk/interpro/entry/IPR002293
Jabion	11136	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=11136
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00901	http://www.genome.jp/dbget-bin/www_bget?H00901
KEGG_Gene	hsa:11136	http://www.genome.jp/dbget-bin/www_bget?hsa:11136
KEGG_Orthology	KO:K13868	http://www.genome.jp/dbget-bin/www_bget?KO:K13868
KEGG_Pathway	ko04974	http://www.genome.jp/kegg-bin/show_pathway?ko04974
MIM	220100	http://www.ncbi.nlm.nih.gov/omim/220100
MIM	604144	http://www.ncbi.nlm.nih.gov/omim/604144
MINT	MINT-3023541	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3023541
OMA	SFSEYVC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SFSEYVC
Orphanet	93613	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=93613
OrthoDB	EOG091G07EM	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07EM
PANTHER	PTHR11785	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785
PSORT	swissprot:BAT1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:BAT1_HUMAN
PSORT-B	swissprot:BAT1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:BAT1_HUMAN
PSORT2	swissprot:BAT1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:BAT1_HUMAN
Pfam	PF13520	http://pfam.xfam.org/family/PF13520
PharmGKB	PA35927	http://www.pharmgkb.org/do/serve?objId=PA35927&objCls=Gene
Phobius	swissprot:BAT1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:BAT1_HUMAN
PhylomeDB	P82251	http://phylomedb.org/?seqid=P82251
ProteinModelPortal	P82251	http://www.proteinmodelportal.org/query/uniprot/P82251
PubMed	10471498	http://www.ncbi.nlm.nih.gov/pubmed/10471498
PubMed	10588648	http://www.ncbi.nlm.nih.gov/pubmed/10588648
PubMed	11157794	http://www.ncbi.nlm.nih.gov/pubmed/11157794
PubMed	11318953	http://www.ncbi.nlm.nih.gov/pubmed/11318953
PubMed	12167606	http://www.ncbi.nlm.nih.gov/pubmed/12167606
PubMed	12234283	http://www.ncbi.nlm.nih.gov/pubmed/12234283
PubMed	12371955	http://www.ncbi.nlm.nih.gov/pubmed/12371955
PubMed	12820697	http://www.ncbi.nlm.nih.gov/pubmed/12820697
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15635077	http://www.ncbi.nlm.nih.gov/pubmed/15635077
PubMed	16138908	http://www.ncbi.nlm.nih.gov/pubmed/16138908
PubMed	16609684	http://www.ncbi.nlm.nih.gov/pubmed/16609684
PubMed	18752446	http://www.ncbi.nlm.nih.gov/pubmed/18752446
PubMed	19782624	http://www.ncbi.nlm.nih.gov/pubmed/19782624
Reactome	R-HSA-210991	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-210991
Reactome	R-HSA-352230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-352230
RefSeq	NP_001119807	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001119807
RefSeq	NP_001229965	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001229965
RefSeq	NP_055085	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055085
RefSeq	XP_011524704	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011524704
STRING	9606.ENSP00000023064	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000023064&targetmode=cogs
TCDB	2.A.3.8.19	http://www.tcdb.org/search/result.php?tc=2.A.3.8.19
UCSC	uc002ntu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ntu&org=rat
UniGene	Hs.743345	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.743345
UniProtKB	BAT1_HUMAN	http://www.uniprot.org/uniprot/BAT1_HUMAN
UniProtKB-AC	P82251	http://www.uniprot.org/uniprot/P82251
charge	swissprot:BAT1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:BAT1_HUMAN
eggNOG	COG0531	http://eggnogapi.embl.de/nog_data/html/tree/COG0531
eggNOG	KOG1287	http://eggnogapi.embl.de/nog_data/html/tree/KOG1287
epestfind	swissprot:BAT1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:BAT1_HUMAN
garnier	swissprot:BAT1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:BAT1_HUMAN
helixturnhelix	swissprot:BAT1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:BAT1_HUMAN
hmoment	swissprot:BAT1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:BAT1_HUMAN
iep	swissprot:BAT1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:BAT1_HUMAN
inforesidue	swissprot:BAT1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:BAT1_HUMAN
neXtProt	NX_P82251	http://www.nextprot.org/db/entry/NX_P82251
octanol	swissprot:BAT1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:BAT1_HUMAN
pepcoil	swissprot:BAT1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:BAT1_HUMAN
pepdigest	swissprot:BAT1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:BAT1_HUMAN
pepinfo	swissprot:BAT1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:BAT1_HUMAN
pepnet	swissprot:BAT1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:BAT1_HUMAN
pepstats	swissprot:BAT1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:BAT1_HUMAN
pepwheel	swissprot:BAT1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:BAT1_HUMAN
pepwindow	swissprot:BAT1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:BAT1_HUMAN
sigcleave	swissprot:BAT1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:BAT1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S35B4_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q969S0-1; Sequence=Displayed; Name=2; IsoId=Q969S0-2; Sequence=VSP_016197, VSP_016198; Name=3; IsoId=Q969S0-3; Sequence=VSP_016199, VSP_016200; Note=No experimental confirmation available.; 
# AltName	S35B4_HUMAN	Solute carrier family 35 member B4
# AltName	S35B4_HUMAN	YEA4 homolog
# BioGrid	124349	3
# CCDS	CCDS34756	-. [Q969S0-1]
# ChiTaRS	SLC35B4	human
# Ensembl	ENST00000378509	ENSP00000367770; ENSG00000205060. [Q969S0-1]
# Ensembl	ENST00000470969	ENSP00000485857; ENSG00000205060. [Q969S0-2]
# ExpressionAtlas	Q969S0	baseline and differential
# FUNCTION	S35B4_HUMAN	Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi. {ECO 0000269|PubMed 15911612}. 
# GO_component	GO:0000139	Golgi membrane; TAS:Reactome.
# GO_component	GO:0005783	endoplasmic reticulum; IDA:CACAO.
# GO_component	GO:0005794	Golgi apparatus; IDA:UniProtKB.
# GO_component	GO:0030173	integral component of Golgi membrane; IBA:GO_Central.
# GO_component	GO:0030176	integral component of endoplasmic reticulum membrane; IBA:GO_Central.
# GO_function	GO:0005457	GDP-fucose transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0005462	UDP-N-acetylglucosamine transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0005464	UDP-xylose transmembrane transporter activity; IDA:UniProtKB.
# GO_process	GO:0006111	regulation of gluconeogenesis; IEA:Ensembl.
# GO_process	GO:0008643	carbohydrate transport; IEA:UniProtKB-KW.
# GO_process	GO:0015783	GDP-fucose transport; IBA:GO_Central.
# GO_process	GO:0015788	UDP-N-acetylglucosamine transport; IDA:UniProtKB.
# GO_process	GO:0015790	UDP-xylose transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q969S0	HS
# HGNC	HGNC:20584	SLC35B4
# INTERACTION	S35B4_HUMAN	Q96BA8 CREB3L1; NbExp=3; IntAct=EBI-10281213, EBI-6942903; 
# IntAct	Q969S0	3
# InterPro	IPR013657	UAA
# KEGG_Brite	ko02001	Solute carrier family
# MIM	610923	gene
# Organism	S35B4_HUMAN	Homo sapiens (Human)
# Pfam	PF08449	UAA
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-727802	Transport of nucleotide sugars
# RecName	S35B4_HUMAN	UDP-xylose and UDP-N-acetylglucosamine transporter
# RefSeq	NP_116215	NM_032826.4. [Q969S0-1]
# SEQUENCE CAUTION	Sequence=BAB55325.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the nucleotide-sugar transporter family. SLC35B subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S35B4_HUMAN	Golgi apparatus membrane {ECO 0000269|PubMed 15911612}; Multi-pass membrane protein {ECO 0000269|PubMed 15911612}. 
# TCDB	2.A.7.10	the drug/metabolite transporter (dmt) superfamily
# UCSC	uc003vrn	human. [Q969S0-1]
# eggNOG	ENOG410XQ16	LUCA
# eggNOG	KOG1583	Eukaryota
BLAST	swissprot:S35B4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S35B4_HUMAN
BioCyc	ZFISH:G66-33036-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33036-MONOMER
COXPRESdb	84912	http://coxpresdb.jp/data/gene/84912.shtml
CleanEx	HS_SLC35B4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC35B4
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M504783200	http://dx.doi.org/10.1074/jbc.M504783200
DOI	10.1093/dnares/12.2.117	http://dx.doi.org/10.1093/dnares/12.2.117
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1083423	http://dx.doi.org/10.1126/science.1083423
EMBL	AB052892	http://www.ebi.ac.uk/ena/data/view/AB052892
EMBL	AC008154	http://www.ebi.ac.uk/ena/data/view/AC008154
EMBL	AJ315497	http://www.ebi.ac.uk/ena/data/view/AJ315497
EMBL	AJ315498	http://www.ebi.ac.uk/ena/data/view/AJ315498
EMBL	AJ971941	http://www.ebi.ac.uk/ena/data/view/AJ971941
EMBL	AK027603	http://www.ebi.ac.uk/ena/data/view/AK027603
EMBL	AK027726	http://www.ebi.ac.uk/ena/data/view/AK027726
EMBL	AK075368	http://www.ebi.ac.uk/ena/data/view/AK075368
EMBL	AK222874	http://www.ebi.ac.uk/ena/data/view/AK222874
EMBL	BC008413	http://www.ebi.ac.uk/ena/data/view/BC008413
EMBL	CH236950	http://www.ebi.ac.uk/ena/data/view/CH236950
EMBL	CH471070	http://www.ebi.ac.uk/ena/data/view/CH471070
Ensembl	ENST00000378509	http://www.ensembl.org/id/ENST00000378509
Ensembl	ENST00000470969	http://www.ensembl.org/id/ENST00000470969
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0030173	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030173
GO_component	GO:0030176	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030176
GO_function	GO:0005457	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005457
GO_function	GO:0005462	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005462
GO_function	GO:0005464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005464
GO_process	GO:0006111	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006111
GO_process	GO:0008643	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008643
GO_process	GO:0015783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015783
GO_process	GO:0015788	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015788
GO_process	GO:0015790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015790
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	SLC35B4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC35B4
GeneID	84912	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84912
GeneTree	ENSGT00390000002915	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002915
HGNC	HGNC:20584	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20584
HOGENOM	HOG000234632	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234632&db=HOGENOM6
HOVERGEN	HBG093926	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG093926&db=HOVERGEN
HPA	HPA049779	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA049779
InParanoid	Q969S0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q969S0
IntAct	Q969S0	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q969S0*
InterPro	IPR013657	http://www.ebi.ac.uk/interpro/entry/IPR013657
Jabion	84912	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=84912
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:84912	http://www.genome.jp/dbget-bin/www_bget?hsa:84912
KEGG_Orthology	KO:K15278	http://www.genome.jp/dbget-bin/www_bget?KO:K15278
MIM	610923	http://www.ncbi.nlm.nih.gov/omim/610923
OMA	IRYYAVM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IRYYAVM
OrthoDB	EOG091G0DEX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0DEX
PSORT	swissprot:S35B4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S35B4_HUMAN
PSORT-B	swissprot:S35B4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S35B4_HUMAN
PSORT2	swissprot:S35B4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S35B4_HUMAN
Pfam	PF08449	http://pfam.xfam.org/family/PF08449
PharmGKB	PA134922110	http://www.pharmgkb.org/do/serve?objId=PA134922110&objCls=Gene
Phobius	swissprot:S35B4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S35B4_HUMAN
PhylomeDB	Q969S0	http://phylomedb.org/?seqid=Q969S0
ProteinModelPortal	Q969S0	http://www.proteinmodelportal.org/query/uniprot/Q969S0
PubMed	12690205	http://www.ncbi.nlm.nih.gov/pubmed/12690205
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15911612	http://www.ncbi.nlm.nih.gov/pubmed/15911612
PubMed	16303743	http://www.ncbi.nlm.nih.gov/pubmed/16303743
Reactome	R-HSA-727802	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-727802
RefSeq	NP_116215	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_116215
STRING	9606.ENSP00000367770	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000367770&targetmode=cogs
TCDB	2.A.7.10	http://www.tcdb.org/search/result.php?tc=2.A.7.10
UCSC	uc003vrn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003vrn&org=rat
UniGene	Hs.490181	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.490181
UniProtKB	S35B4_HUMAN	http://www.uniprot.org/uniprot/S35B4_HUMAN
UniProtKB-AC	Q969S0	http://www.uniprot.org/uniprot/Q969S0
charge	swissprot:S35B4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S35B4_HUMAN
eggNOG	ENOG410XQ16	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ16
eggNOG	KOG1583	http://eggnogapi.embl.de/nog_data/html/tree/KOG1583
epestfind	swissprot:S35B4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S35B4_HUMAN
garnier	swissprot:S35B4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S35B4_HUMAN
helixturnhelix	swissprot:S35B4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S35B4_HUMAN
hmoment	swissprot:S35B4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S35B4_HUMAN
iep	swissprot:S35B4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S35B4_HUMAN
inforesidue	swissprot:S35B4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S35B4_HUMAN
neXtProt	NX_Q969S0	http://www.nextprot.org/db/entry/NX_Q969S0
octanol	swissprot:S35B4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S35B4_HUMAN
pepcoil	swissprot:S35B4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S35B4_HUMAN
pepdigest	swissprot:S35B4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S35B4_HUMAN
pepinfo	swissprot:S35B4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S35B4_HUMAN
pepnet	swissprot:S35B4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S35B4_HUMAN
pepstats	swissprot:S35B4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S35B4_HUMAN
pepwheel	swissprot:S35B4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S35B4_HUMAN
pepwindow	swissprot:S35B4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S35B4_HUMAN
sigcleave	swissprot:S35B4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S35B4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ANO3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BYT9-1; Sequence=Displayed; Name=2; IsoId=Q9BYT9-2; Sequence=VSP_056893; Note=No experimental confirmation available.; 
# AltName	ANO3_HUMAN	Transmembrane protein 16C
# BioGrid	122027	8
# CCDS	CCDS31447	-. [Q9BYT9-1]
# CCDS	CCDS81557	-. [Q9BYT9-2]
# ChiTaRS	ANO3	human
# DISEASE	ANO3_HUMAN	Dystonia 24 (DYT24) [MIM 615034]  A form of dystonia, a disorder defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYT24 is an autosomal dominant focal dystonia affecting the neck, laryngeal muscles, and muscles of the upper limbs. {ECO 0000269|PubMed 23200863}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000256737	ENSP00000256737; ENSG00000134343. [Q9BYT9-1]
# Ensembl	ENST00000531568	ENSP00000432394; ENSG00000134343. [Q9BYT9-2]
# ExpressionAtlas	Q9BYT9	baseline and differential
# FUNCTION	ANO3_HUMAN	Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide. Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. {ECO 0000250|UniProtKB A2AHL1, ECO 0000269|PubMed 21984732}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005229	intracellular calcium activated chloride channel activity; TAS:Reactome.
# GO_function	GO:0017128	phospholipid scramblase activity; IEA:Ensembl.
# GO_process	GO:0016048	detection of temperature stimulus; IEA:Ensembl.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0050982	detection of mechanical stimulus; IEA:Ensembl.
# GO_process	GO:0061590	calcium activated phosphatidylcholine scrambling; IEA:Ensembl.
# GO_process	GO:0061591	calcium activated galactosylceramide scrambling; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0007009	plasma membrane organization
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9BYT9	HS
# HGNC	HGNC:14004	ANO3
# IntAct	Q9BYT9	8
# InterPro	IPR007632	Anoctamin
# InterPro	IPR031292	Anoctamin-3
# InterPro	IPR032394	Anoct_dimer
# MIM	610110	gene
# MIM	615034	phenotype
# MISCELLANEOUS	ANO3_HUMAN	The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology. 
# Organism	ANO3_HUMAN	Homo sapiens (Human)
# Orphanet	93962	Autosomal dominant cervical dystonia
# PANTHER	PTHR12308	PTHR12308
# PANTHER	PTHR12308:SF16	PTHR12308:SF16
# Pfam	PF04547	Anoctamin
# Pfam	PF16178	Anoct_dimer
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	ANO3_HUMAN	Anoctamin-3
# RefSeq	NP_001300655	NM_001313726.1
# RefSeq	NP_001300656	NM_001313727.1. [Q9BYT9-2]
# RefSeq	NP_113606	NM_031418.3. [Q9BYT9-1]
# RefSeq	XP_016873607	XM_017018118.1. [Q9BYT9-2]
# SIMILARITY	Belongs to the anoctamin family. {ECO	0000305}.
# SUBCELLULAR LOCATION	ANO3_HUMAN	Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. Note=Shows an intracellular localization. {ECO 0000250}. 
# SUBUNIT	Interacts with KCNT1/Slack. {ECO:0000250|UniProtKB	A2AHL1}. 
# TCDB	1.A.17.1.20	the calcium-dependent chloride channel (ca-clc) family
# TISSUE SPECIFICITY	Highly expressed in the forebrain striatum. {ECO:0000269|PubMed	23200863}. 
# UCSC	uc001mqt	human. [Q9BYT9-1]
# eggNOG	ENOG410XS4S	LUCA
# eggNOG	KOG2514	Eukaryota
BLAST	swissprot:ANO3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ANO3_HUMAN
BioCyc	ZFISH:ENSG00000134343-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000134343-MONOMER
COXPRESdb	63982	http://coxpresdb.jp/data/gene/63982.shtml
CleanEx	HS_ANO3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ANO3
DOI	10.1007/s00424-011-0975-9	http://dx.doi.org/10.1007/s00424-011-0975-9
DOI	10.1016/j.ajhg.2012.10.024	http://dx.doi.org/10.1016/j.ajhg.2012.10.024
DOI	10.1038/aps.2011.48	http://dx.doi.org/10.1038/aps.2011.48
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1113/expphysiol.2011.058198	http://dx.doi.org/10.1113/expphysiol.2011.058198
DOI	10.1113/expphysiol.2011.058214	http://dx.doi.org/10.1113/expphysiol.2011.058214
EMBL	AC021698	http://www.ebi.ac.uk/ena/data/view/AC021698
EMBL	AC036114	http://www.ebi.ac.uk/ena/data/view/AC036114
EMBL	AC079064	http://www.ebi.ac.uk/ena/data/view/AC079064
EMBL	AC083755	http://www.ebi.ac.uk/ena/data/view/AC083755
EMBL	AC099687	http://www.ebi.ac.uk/ena/data/view/AC099687
EMBL	AJ300461	http://www.ebi.ac.uk/ena/data/view/AJ300461
EMBL	AK295816	http://www.ebi.ac.uk/ena/data/view/AK295816
Ensembl	ENST00000256737	http://www.ensembl.org/id/ENST00000256737
Ensembl	ENST00000531568	http://www.ensembl.org/id/ENST00000531568
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005229	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005229
GO_function	GO:0017128	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017128
GO_process	GO:0016048	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016048
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0050982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050982
GO_process	GO:0061590	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061590
GO_process	GO:0061591	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061591
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0007009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007009
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ANO3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ANO3
GeneID	63982	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=63982
GeneTree	ENSGT00760000119015	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119015
H-InvDB	HIX0035914	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0035914
HGNC	HGNC:14004	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14004
HOGENOM	HOG000006509	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006509&db=HOGENOM6
HOVERGEN	HBG069519	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG069519&db=HOVERGEN
HPA	HPA041629	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA041629
InParanoid	Q9BYT9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9BYT9
IntAct	Q9BYT9	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9BYT9*
InterPro	IPR007632	http://www.ebi.ac.uk/interpro/entry/IPR007632
InterPro	IPR031292	http://www.ebi.ac.uk/interpro/entry/IPR031292
InterPro	IPR032394	http://www.ebi.ac.uk/interpro/entry/IPR032394
Jabion	63982	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=63982
KEGG_Gene	hsa:63982	http://www.genome.jp/dbget-bin/www_bget?hsa:63982
MIM	610110	http://www.ncbi.nlm.nih.gov/omim/610110
MIM	615034	http://www.ncbi.nlm.nih.gov/omim/615034
OMA	EICEANE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EICEANE
Orphanet	93962	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=93962
OrthoDB	EOG091G01JF	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01JF
PANTHER	PTHR12308	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12308
PANTHER	PTHR12308:SF16	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12308:SF16
PSORT	swissprot:ANO3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ANO3_HUMAN
PSORT-B	swissprot:ANO3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ANO3_HUMAN
PSORT2	swissprot:ANO3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ANO3_HUMAN
Pfam	PF04547	http://pfam.xfam.org/family/PF04547
Pfam	PF16178	http://pfam.xfam.org/family/PF16178
PharmGKB	PA25489	http://www.pharmgkb.org/do/serve?objId=PA25489&objCls=Gene
Phobius	swissprot:ANO3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ANO3_HUMAN
PhylomeDB	Q9BYT9	http://phylomedb.org/?seqid=Q9BYT9
ProteinModelPortal	Q9BYT9	http://www.proteinmodelportal.org/query/uniprot/Q9BYT9
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	21607626	http://www.ncbi.nlm.nih.gov/pubmed/21607626
PubMed	21642943	http://www.ncbi.nlm.nih.gov/pubmed/21642943
PubMed	21984732	http://www.ncbi.nlm.nih.gov/pubmed/21984732
PubMed	22302790	http://www.ncbi.nlm.nih.gov/pubmed/22302790
PubMed	23200863	http://www.ncbi.nlm.nih.gov/pubmed/23200863
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_001300655	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001300655
RefSeq	NP_001300656	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001300656
RefSeq	NP_113606	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_113606
RefSeq	XP_016873607	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016873607
STRING	9606.ENSP00000256737	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000256737&targetmode=cogs
TCDB	1.A.17.1.20	http://www.tcdb.org/search/result.php?tc=1.A.17.1.20
UCSC	uc001mqt	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001mqt&org=rat
UniGene	Hs.577269	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.577269
UniGene	Hs.91791	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.91791
UniProtKB	ANO3_HUMAN	http://www.uniprot.org/uniprot/ANO3_HUMAN
UniProtKB-AC	Q9BYT9	http://www.uniprot.org/uniprot/Q9BYT9
charge	swissprot:ANO3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ANO3_HUMAN
eggNOG	ENOG410XS4S	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS4S
eggNOG	KOG2514	http://eggnogapi.embl.de/nog_data/html/tree/KOG2514
epestfind	swissprot:ANO3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ANO3_HUMAN
garnier	swissprot:ANO3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ANO3_HUMAN
helixturnhelix	swissprot:ANO3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ANO3_HUMAN
hmoment	swissprot:ANO3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ANO3_HUMAN
iep	swissprot:ANO3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ANO3_HUMAN
inforesidue	swissprot:ANO3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ANO3_HUMAN
neXtProt	NX_Q9BYT9	http://www.nextprot.org/db/entry/NX_Q9BYT9
octanol	swissprot:ANO3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ANO3_HUMAN
pepcoil	swissprot:ANO3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ANO3_HUMAN
pepdigest	swissprot:ANO3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ANO3_HUMAN
pepinfo	swissprot:ANO3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ANO3_HUMAN
pepnet	swissprot:ANO3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ANO3_HUMAN
pepstats	swissprot:ANO3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ANO3_HUMAN
pepwheel	swissprot:ANO3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ANO3_HUMAN
pepwindow	swissprot:ANO3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ANO3_HUMAN
sigcleave	swissprot:ANO3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ANO3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	EAA4_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P48664-1; Sequence=Displayed; Name=2; IsoId=P48664-2; Sequence=VSP_055130; 
# AltName	EAA4_HUMAN	Sodium-dependent glutamate/aspartate transporter
# AltName	EAA4_HUMAN	Solute carrier family 1 member 6
# CCDS	CCDS12321	-. [P48664-1]
# CCDS	CCDS62578	-. [P48664-2]
# Ensembl	ENST00000221742	ENSP00000221742; ENSG00000105143. [P48664-1]
# Ensembl	ENST00000544886	ENSP00000446175; ENSG00000105143. [P48664-2]
# Ensembl	ENST00000598504	ENSP00000471781; ENSG00000105143. [P48664-2]
# ExpressionAtlas	P48664	baseline and differential
# FUNCTION	EAA4_HUMAN	Transports L-glutamate and also L- and D-aspartate. Seems to act as a symport by cotransporting sodium. 
# GO_component	GO:0005794	Golgi apparatus; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_function	GO:0005314	high-affinity glutamate transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015183	L-aspartate transmembrane transporter activity; TAS:ProtInc.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:ProtInc.
# GO_process	GO:0014047	glutamate secretion; TAS:Reactome.
# GO_process	GO:0015810	aspartate transport; TAS:ProtInc.
# GO_process	GO:0015813	L-glutamate transport; TAS:ProtInc.
# GO_process	GO:0042391	regulation of membrane potential; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.10.3860.10	-; 2.
# Genevisible	P48664	HS
# HGNC	HGNC:10944	SLC1A6
# InterPro	IPR001991	Na-dicarboxylate_symporter
# InterPro	IPR018107	Na-dicarboxylate_symporter_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04724	Glutamatergic synapse
# MIM	600637	gene
# Organism	EAA4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11958	PTHR11958; 2
# PIR	S58398	S58398
# PRINTS	PR00173	EDTRNSPORT
# PROSITE	PS00713	NA_DICARBOXYL_SYMP_1
# PROSITE	PS00714	NA_DICARBOXYL_SYMP_2
# Pfam	PF00375	SDF
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-210500	Glutamate Neurotransmitter Release Cycle
# Reactome	R-HSA-425393	Transport of inorganic cations/anions and amino acids/oligopeptides
# RecName	EAA4_HUMAN	Excitatory amino acid transporter 4
# RefSeq	NP_001259016	NM_001272087.1. [P48664-2]
# RefSeq	NP_001259017	NM_001272088.1. [P48664-2]
# RefSeq	NP_005062	NM_005071.2. [P48664-1]
# RefSeq	XP_006722905	XM_006722842.1. [P48664-1]
# RefSeq	XP_006722907	XM_006722844.1. [P48664-1]
# RefSeq	XP_016882641	XM_017027152.1. [P48664-1]
# SIMILARITY	Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A6 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	EAA4_HUMAN	Membrane; Multi-pass membrane protein. 
# SUPFAM	SSF118215	SSF118215; 2
# TCDB	2.A.23.2:the dicarboxylate/amino acid	cation (na(+) or h(+)) symporter (daacs) family
# TISSUE SPECIFICITY	EAA4_HUMAN	Brain. Expressed densely and selectively in cell bodies of Purkinje cells. 
# UCSC	uc002naa	human. [P48664-1]
# eggNOG	COG1301	LUCA
# eggNOG	KOG3787	Eukaryota
BLAST	swissprot:EAA4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:EAA4_HUMAN
BioCyc	ZFISH:ENSG00000105143-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000105143-MONOMER
COXPRESdb	6511	http://coxpresdb.jp/data/gene/6511.shtml
CleanEx	HS_SLC1A6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC1A6
DOI	10.1038/375599a0	http://dx.doi.org/10.1038/375599a0
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC004659	http://www.ebi.ac.uk/ena/data/view/AC004659
EMBL	AC104528	http://www.ebi.ac.uk/ena/data/view/AC104528
EMBL	BC028721	http://www.ebi.ac.uk/ena/data/view/BC028721
EMBL	BC040604	http://www.ebi.ac.uk/ena/data/view/BC040604
EMBL	U18244	http://www.ebi.ac.uk/ena/data/view/U18244
Ensembl	ENST00000221742	http://www.ensembl.org/id/ENST00000221742
Ensembl	ENST00000544886	http://www.ensembl.org/id/ENST00000544886
Ensembl	ENST00000598504	http://www.ensembl.org/id/ENST00000598504
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0005314	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005314
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_function	GO:0015183	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015183
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0014047	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014047
GO_process	GO:0015810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015810
GO_process	GO:0015813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015813
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.10.3860.10	http://www.cathdb.info/version/latest/superfamily/1.10.3860.10
GeneCards	SLC1A6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC1A6
GeneID	6511	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6511
GeneTree	ENSGT00760000119117	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119117
HGNC	HGNC:10944	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10944
HOGENOM	HOG000208776	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000208776&db=HOGENOM6
HOVERGEN	HBG000080	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000080&db=HOVERGEN
HPA	HPA041505	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA041505
HPA	HPA044066	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA044066
InParanoid	P48664	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P48664
IntAct	P48664	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P48664*
InterPro	IPR001991	http://www.ebi.ac.uk/interpro/entry/IPR001991
InterPro	IPR018107	http://www.ebi.ac.uk/interpro/entry/IPR018107
Jabion	6511	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6511
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6511	http://www.genome.jp/dbget-bin/www_bget?hsa:6511
KEGG_Orthology	KO:K05617	http://www.genome.jp/dbget-bin/www_bget?KO:K05617
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
MIM	600637	http://www.ncbi.nlm.nih.gov/omim/600637
OMA	IAVYIGC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IAVYIGC
OrthoDB	EOG091G0UCE	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0UCE
PANTHER	PTHR11958	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11958
PRINTS	PR00173	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00173
PROSITE	PS00713	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00713
PROSITE	PS00714	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00714
PSORT	swissprot:EAA4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:EAA4_HUMAN
PSORT-B	swissprot:EAA4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:EAA4_HUMAN
PSORT2	swissprot:EAA4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:EAA4_HUMAN
Pfam	PF00375	http://pfam.xfam.org/family/PF00375
PharmGKB	PA35831	http://www.pharmgkb.org/do/serve?objId=PA35831&objCls=Gene
Phobius	swissprot:EAA4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:EAA4_HUMAN
PhylomeDB	P48664	http://phylomedb.org/?seqid=P48664
ProteinModelPortal	P48664	http://www.proteinmodelportal.org/query/uniprot/P48664
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	7791878	http://www.ncbi.nlm.nih.gov/pubmed/7791878
Reactome	R-HSA-210500	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-210500
Reactome	R-HSA-425393	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425393
RefSeq	NP_001259016	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001259016
RefSeq	NP_001259017	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001259017
RefSeq	NP_005062	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005062
RefSeq	XP_006722905	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006722905
RefSeq	XP_006722907	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006722907
RefSeq	XP_016882641	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016882641
STRING	9606.ENSP00000221742	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000221742&targetmode=cogs
SUPFAM	SSF118215	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF118215
TCDB	2.A.23.2	http://www.tcdb.org/search/result.php?tc=2.A.23.2
UCSC	uc002naa	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002naa&org=rat
UniGene	Hs.515217	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.515217
UniGene	Hs.733178	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.733178
UniProtKB	EAA4_HUMAN	http://www.uniprot.org/uniprot/EAA4_HUMAN
UniProtKB-AC	P48664	http://www.uniprot.org/uniprot/P48664
charge	swissprot:EAA4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:EAA4_HUMAN
eggNOG	COG1301	http://eggnogapi.embl.de/nog_data/html/tree/COG1301
eggNOG	KOG3787	http://eggnogapi.embl.de/nog_data/html/tree/KOG3787
epestfind	swissprot:EAA4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:EAA4_HUMAN
garnier	swissprot:EAA4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:EAA4_HUMAN
helixturnhelix	swissprot:EAA4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:EAA4_HUMAN
hmoment	swissprot:EAA4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:EAA4_HUMAN
iep	swissprot:EAA4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:EAA4_HUMAN
inforesidue	swissprot:EAA4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:EAA4_HUMAN
neXtProt	NX_P48664	http://www.nextprot.org/db/entry/NX_P48664
octanol	swissprot:EAA4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:EAA4_HUMAN
pepcoil	swissprot:EAA4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:EAA4_HUMAN
pepdigest	swissprot:EAA4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:EAA4_HUMAN
pepinfo	swissprot:EAA4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:EAA4_HUMAN
pepnet	swissprot:EAA4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:EAA4_HUMAN
pepstats	swissprot:EAA4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:EAA4_HUMAN
pepwheel	swissprot:EAA4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:EAA4_HUMAN
pepwindow	swissprot:EAA4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:EAA4_HUMAN
sigcleave	swissprot:EAA4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:EAA4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TMCO6_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96DC7-1; Sequence=Displayed; Name=2; IsoId=Q96DC7-2; Sequence=VSP_028249; Note=No experimental confirmation available.; 
# BioGrid	120647	8
# CCDS	CCDS4233	-. [Q96DC7-1]
# CCDS	CCDS75320	-. [Q96DC7-2]
# ChiTaRS	TMCO6	human
# Ensembl	ENST00000252100	ENSP00000252100; ENSG00000113119. [Q96DC7-2]
# Ensembl	ENST00000394671	ENSP00000378166; ENSG00000113119. [Q96DC7-1]
# ExpressionAtlas	Q96DC7	baseline and differential
# GO_component	GO:0005634	nucleus; IEA:InterPro.
# GO_component	GO:0005737	cytoplasm; IEA:InterPro.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0008565	protein transporter activity; IEA:InterPro.
# GO_process	GO:0006606	protein import into nucleus; IEA:InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005737	cytoplasm
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# Gene3D	1.25.10.10	-; 1.
# Genevisible	Q96DC7	HS
# HGNC	HGNC:28814	TMCO6
# INTERACTION	TMCO6_HUMAN	Q9UMX0 UBQLN1; NbExp=3; IntAct=EBI-10284552, EBI-741480; Q9UMX0-2 UBQLN1; NbExp=3; IntAct=EBI-10284552, EBI-10173939; 
# InterPro	IPR000225	Armadillo
# InterPro	IPR002652	Importin-a_IBB
# InterPro	IPR011989	ARM-like
# InterPro	IPR016024	ARM-type_fold
# Organism	TMCO6_HUMAN	Homo sapiens (Human)
# Proteomes	UP000005640	Chromosome 5
# RecName	TMCO6_HUMAN	Transmembrane and coiled-coil domain-containing protein 6
# RefSeq	NP_001287909	NM_001300980.1. [Q96DC7-2]
# RefSeq	NP_001287911	NM_001300982.1
# RefSeq	NP_060972	NM_018502.4. [Q96DC7-1]
# RefSeq	XP_011535970	XM_011537668.2
# RefSeq	XP_016865109	XM_017009620.1
# SEQUENCE CAUTION	TMCO6_HUMAN	Sequence=AAF69602.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO 0000305}; Sequence=AAH01910.1; Type=Erroneous initiation; Evidence={ECO 0000305}; Sequence=AAH09618.1; Type=Erroneous initiation; Evidence={ECO 0000305}; Sequence=EAW62034.1; Type=Erroneous gene model prediction; Evidence={ECO 0000305};
# SMART	SM00185	ARM; 5
# SUBCELLULAR LOCATION	TMCO6_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF48371	SSF48371
# UCSC	uc003lgl	human. [Q96DC7-1]
# eggNOG	ENOG410IE0G	Eukaryota
# eggNOG	ENOG41126GB	LUCA
BLAST	swissprot:TMCO6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TMCO6_HUMAN
BioCyc	ZFISH:ENSG00000113119-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000113119-MONOMER
COXPRESdb	55374	http://coxpresdb.jp/data/gene/55374.shtml
CleanEx	HS_TMCO6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TMCO6
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF119848	http://www.ebi.ac.uk/ena/data/view/AF119848
EMBL	AK097088	http://www.ebi.ac.uk/ena/data/view/AK097088
EMBL	BC001910	http://www.ebi.ac.uk/ena/data/view/BC001910
EMBL	BC009618	http://www.ebi.ac.uk/ena/data/view/BC009618
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
Ensembl	ENST00000252100	http://www.ensembl.org/id/ENST00000252100
Ensembl	ENST00000394671	http://www.ensembl.org/id/ENST00000394671
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0006606	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006606
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
GeneCards	TMCO6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TMCO6
GeneID	55374	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55374
GeneTree	ENSGT00390000008104	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000008104
HGNC	HGNC:28814	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:28814
HOGENOM	HOG000154636	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000154636&db=HOGENOM6
HOVERGEN	HBG108588	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108588&db=HOVERGEN
HPA	HPA037473	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA037473
HPA	HPA037474	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA037474
InParanoid	Q96DC7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96DC7
IntAct	Q96DC7	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96DC7*
InterPro	IPR000225	http://www.ebi.ac.uk/interpro/entry/IPR000225
InterPro	IPR002652	http://www.ebi.ac.uk/interpro/entry/IPR002652
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
Jabion	55374	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55374
KEGG_Gene	hsa:55374	http://www.genome.jp/dbget-bin/www_bget?hsa:55374
MINT	MINT-1453411	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1453411
OMA	ASTLPQH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ASTLPQH
OrthoDB	EOG091G055O	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G055O
PSORT	swissprot:TMCO6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TMCO6_HUMAN
PSORT-B	swissprot:TMCO6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TMCO6_HUMAN
PSORT2	swissprot:TMCO6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TMCO6_HUMAN
PharmGKB	PA162405810	http://www.pharmgkb.org/do/serve?objId=PA162405810&objCls=Gene
Phobius	swissprot:TMCO6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TMCO6_HUMAN
PhylomeDB	Q96DC7	http://phylomedb.org/?seqid=Q96DC7
ProteinModelPortal	Q96DC7	http://www.proteinmodelportal.org/query/uniprot/Q96DC7
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
RefSeq	NP_001287909	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001287909
RefSeq	NP_001287911	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001287911
RefSeq	NP_060972	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060972
RefSeq	XP_011535970	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011535970
RefSeq	XP_016865109	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016865109
SMART	SM00185	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00185
STRING	9606.ENSP00000378166	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000378166&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
UCSC	uc003lgl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003lgl&org=rat
UniGene	Hs.534333	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.534333
UniProtKB	TMCO6_HUMAN	http://www.uniprot.org/uniprot/TMCO6_HUMAN
UniProtKB-AC	Q96DC7	http://www.uniprot.org/uniprot/Q96DC7
charge	swissprot:TMCO6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TMCO6_HUMAN
eggNOG	ENOG410IE0G	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IE0G
eggNOG	ENOG41126GB	http://eggnogapi.embl.de/nog_data/html/tree/ENOG41126GB
epestfind	swissprot:TMCO6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TMCO6_HUMAN
garnier	swissprot:TMCO6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TMCO6_HUMAN
helixturnhelix	swissprot:TMCO6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TMCO6_HUMAN
hmoment	swissprot:TMCO6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TMCO6_HUMAN
iep	swissprot:TMCO6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TMCO6_HUMAN
inforesidue	swissprot:TMCO6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TMCO6_HUMAN
neXtProt	NX_Q96DC7	http://www.nextprot.org/db/entry/NX_Q96DC7
octanol	swissprot:TMCO6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TMCO6_HUMAN
pepcoil	swissprot:TMCO6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TMCO6_HUMAN
pepdigest	swissprot:TMCO6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TMCO6_HUMAN
pepinfo	swissprot:TMCO6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TMCO6_HUMAN
pepnet	swissprot:TMCO6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TMCO6_HUMAN
pepstats	swissprot:TMCO6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TMCO6_HUMAN
pepwheel	swissprot:TMCO6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TMCO6_HUMAN
pepwindow	swissprot:TMCO6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TMCO6_HUMAN
sigcleave	swissprot:TMCO6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TMCO6_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CLCN4_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P51793-1; Sequence=Displayed; Name=2; IsoId=P51793-2; Sequence=VSP_054658; Note=No experimental confirmation available.; 
# AltName	CLCN4_HUMAN	Chloride channel protein 4
# AltName	CLCN4_HUMAN	Chloride transporter ClC-4
# CCDS	CCDS14137	-. [P51793-1]
# CCDS	CCDS59159	-. [P51793-2]
# ChiTaRS	CLCN4	human
# Ensembl	ENST00000380833	ENSP00000370213; ENSG00000073464. [P51793-1]
# Ensembl	ENST00000421085	ENSP00000405754; ENSG00000073464. [P51793-2]
# ExpressionAtlas	P51793	baseline and differential
# FUNCTION	CLCN4_HUMAN	Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. {ECO 0000269|PubMed 18063579}. 
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0010008	endosome membrane; TAS:Reactome.
# GO_component	GO:0031901	early endosome membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0031902	late endosome membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0005247	voltage-gated chloride channel activity; TAS:ProtInc.
# GO_function	GO:0005254	chloride channel activity; IDA:MGI.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0015297	antiporter activity; TAS:Reactome.
# GO_function	GO:0031404	chloride ion binding; IBA:GO_Central.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006821	chloride transport; IDA:MGI.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.10.3080.10	-; 3.
# Genevisible	P51793	HS
# HGNC	HGNC:2022	CLCN4
# InterPro	IPR000644	CBS_dom
# InterPro	IPR001807	Cl-channel_volt-gated
# InterPro	IPR002246	Cl_channel-4
# InterPro	IPR014743	Cl-channel_core
# KEGG_Brite	ko04040	Ion channels
# MIM	302910	gene
# MISCELLANEOUS	CLCN4_HUMAN	The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters. 
# Organism	CLCN4_HUMAN	Homo sapiens (Human)
# PIR	I37242	I37242
# PRINTS	PR00762	CLCHANNEL
# PRINTS	PR01115	CLCHANNEL4
# PROSITE	PS51371	CBS; 2
# Pfam	PF00571	CBS; 2
# Pfam	PF00654	Voltage_CLC
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	CLCN4_HUMAN	H(+)/Cl(-) exchange transporter 4
# RefSeq	NP_001243873	NM_001256944.1. [P51793-2]
# RefSeq	NP_001821	NM_001830.3. [P51793-1]
# SIMILARITY	Belongs to the chloride channel (TC 2.A.49) family. ClC-4/CLCN4 subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 2 CBS domains. {ECO:0000255|PROSITE- ProRule	PRU00703}.
# SMART	SM00116	CBS; 2
# SUBCELLULAR LOCATION	CLCN4_HUMAN	Early endosome membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Late endosome membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUPFAM	SSF81340	SSF81340; 3
# TCDB	2.A.49.2	the chloride carrier/channel (clc) family
# TISSUE SPECIFICITY	CLCN4_HUMAN	Abundant in skeletal muscle and also detectable in brain and heart. 
# UCSC	uc004csy	human. [P51793-1]
# eggNOG	COG0038	LUCA
# eggNOG	KOG0475	Eukaryota
BLAST	swissprot:CLCN4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CLCN4_HUMAN
BioCyc	ZFISH:ENSG00000073464-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000073464-MONOMER
COXPRESdb	1183	http://coxpresdb.jp/data/gene/1183.shtml
CleanEx	HS_CLCN4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CLCN4
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M708368200	http://dx.doi.org/10.1074/jbc.M708368200
DOI	10.1093/hmg/3.4.547	http://dx.doi.org/10.1093/hmg/3.4.547
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB019432	http://www.ebi.ac.uk/ena/data/view/AB019432
EMBL	AC003666	http://www.ebi.ac.uk/ena/data/view/AC003666
EMBL	AC121345	http://www.ebi.ac.uk/ena/data/view/AC121345
EMBL	AF170492	http://www.ebi.ac.uk/ena/data/view/AF170492
EMBL	AK289564	http://www.ebi.ac.uk/ena/data/view/AK289564
EMBL	AK299611	http://www.ebi.ac.uk/ena/data/view/AK299611
EMBL	BC130278	http://www.ebi.ac.uk/ena/data/view/BC130278
EMBL	CH471074	http://www.ebi.ac.uk/ena/data/view/CH471074
EMBL	X77197	http://www.ebi.ac.uk/ena/data/view/X77197
Ensembl	ENST00000380833	http://www.ensembl.org/id/ENST00000380833
Ensembl	ENST00000421085	http://www.ensembl.org/id/ENST00000421085
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0010008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010008
GO_component	GO:0031901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031901
GO_component	GO:0031902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031902
GO_function	GO:0005247	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005247
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0015297	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297
GO_function	GO:0031404	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031404
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006821
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.10.3080.10	http://www.cathdb.info/version/latest/superfamily/1.10.3080.10
GeneCards	CLCN4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CLCN4
GeneID	1183	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1183
GeneTree	ENSGT00760000119109	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119109
H-InvDB	HIX0056096	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0056096
HGNC	HGNC:2022	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2022
HOGENOM	HOG000164493	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000164493&db=HOGENOM6
HOVERGEN	HBG050984	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050984&db=HOVERGEN
HPA	HPA031313	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031313
HPA	HPA063637	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA063637
InParanoid	P51793	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P51793
InterPro	IPR000644	http://www.ebi.ac.uk/interpro/entry/IPR000644
InterPro	IPR001807	http://www.ebi.ac.uk/interpro/entry/IPR001807
InterPro	IPR002246	http://www.ebi.ac.uk/interpro/entry/IPR002246
InterPro	IPR014743	http://www.ebi.ac.uk/interpro/entry/IPR014743
Jabion	1183	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1183
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:1183	http://www.genome.jp/dbget-bin/www_bget?hsa:1183
KEGG_Orthology	KO:K05013	http://www.genome.jp/dbget-bin/www_bget?KO:K05013
MIM	302910	http://www.ncbi.nlm.nih.gov/omim/302910
MINT	MINT-3019161	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3019161
OMA	HRKITNK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HRKITNK
OrthoDB	EOG091G01YH	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01YH
PRINTS	PR00762	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00762
PRINTS	PR01115	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01115
PROSITE	PS51371	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51371
PSORT	swissprot:CLCN4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CLCN4_HUMAN
PSORT-B	swissprot:CLCN4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CLCN4_HUMAN
PSORT2	swissprot:CLCN4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CLCN4_HUMAN
Pfam	PF00571	http://pfam.xfam.org/family/PF00571
Pfam	PF00654	http://pfam.xfam.org/family/PF00654
PharmGKB	PA26549	http://www.pharmgkb.org/do/serve?objId=PA26549&objCls=Gene
Phobius	swissprot:CLCN4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CLCN4_HUMAN
PhylomeDB	P51793	http://phylomedb.org/?seqid=P51793
ProteinModelPortal	P51793	http://www.proteinmodelportal.org/query/uniprot/P51793
PubMed	10564087	http://www.ncbi.nlm.nih.gov/pubmed/10564087
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	18063579	http://www.ncbi.nlm.nih.gov/pubmed/18063579
PubMed	8069296	http://www.ncbi.nlm.nih.gov/pubmed/8069296
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_001243873	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243873
RefSeq	NP_001821	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001821
SMART	SM00116	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00116
SMR	P51793	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P51793
STRING	9606.ENSP00000370213	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000370213&targetmode=cogs
SUPFAM	SSF81340	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81340
TCDB	2.A.49.2	http://www.tcdb.org/search/result.php?tc=2.A.49.2
UCSC	uc004csy	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004csy&org=rat
UniGene	Hs.495674	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.495674
UniProtKB	CLCN4_HUMAN	http://www.uniprot.org/uniprot/CLCN4_HUMAN
UniProtKB-AC	P51793	http://www.uniprot.org/uniprot/P51793
charge	swissprot:CLCN4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CLCN4_HUMAN
eggNOG	COG0038	http://eggnogapi.embl.de/nog_data/html/tree/COG0038
eggNOG	KOG0475	http://eggnogapi.embl.de/nog_data/html/tree/KOG0475
epestfind	swissprot:CLCN4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CLCN4_HUMAN
garnier	swissprot:CLCN4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CLCN4_HUMAN
helixturnhelix	swissprot:CLCN4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLCN4_HUMAN
hmoment	swissprot:CLCN4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CLCN4_HUMAN
iep	swissprot:CLCN4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CLCN4_HUMAN
inforesidue	swissprot:CLCN4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CLCN4_HUMAN
neXtProt	NX_P51793	http://www.nextprot.org/db/entry/NX_P51793
octanol	swissprot:CLCN4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CLCN4_HUMAN
pepcoil	swissprot:CLCN4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CLCN4_HUMAN
pepdigest	swissprot:CLCN4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CLCN4_HUMAN
pepinfo	swissprot:CLCN4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CLCN4_HUMAN
pepnet	swissprot:CLCN4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CLCN4_HUMAN
pepstats	swissprot:CLCN4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CLCN4_HUMAN
pepwheel	swissprot:CLCN4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CLCN4_HUMAN
pepwindow	swissprot:CLCN4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CLCN4_HUMAN
sigcleave	swissprot:CLCN4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CLCN4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ABCG5_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H222-1; Sequence=Displayed; Name=2; IsoId=Q9H222-2; Sequence=VSP_055770; Note=No experimental confirmation available.; 
# AltName	ABCG5_HUMAN	Sterolin-1
# BioGrid	122124	2
# CCDS	CCDS1814	-. [Q9H222-1]
# DISEASE	ABCG5_HUMAN	Sitosterolemia (STSL) [MIM 210250]  Rare autosomal recessive disorder characterized by increased intestinal absorption of all sterols including cholesterol, plant and shellfish sterols, and decreased biliary excretion of dietary sterols into bile. Sitosterolemia patients have hypercholesterolemia, very high levels of plant sterols in the plasma, and frequently develop tendon and tuberous xanthomas, accelerated atherosclerosis and premature coronary artery disease. {ECO 0000269|PubMed 11138003, ECO 0000269|PubMed 11452359, ECO 0000269|PubMed 11668628}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00973	Ezetimibe
# Ensembl	ENST00000260645	ENSP00000260645; ENSG00000138075. [Q9H222-1]
# ExpressionAtlas	Q9H222	baseline and differential
# FUNCTION	ABCG5_HUMAN	Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016324	apical plasma membrane; IMP:BHF-UCL.
# GO_component	GO:0043190	ATP-binding cassette (ABC) transporter complex; IDA:BHF-UCL.
# GO_component	GO:0043235	receptor complex; IDA:BHF-UCL.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0017127	cholesterol transporter activity; IEA:Ensembl.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; IBA:GO_Central.
# GO_function	GO:0046982	protein heterodimerization activity; IPI:BHF-UCL.
# GO_process	GO:0007584	response to nutrient; IEA:Ensembl.
# GO_process	GO:0007588	excretion; IGI:BHF-UCL.
# GO_process	GO:0010212	response to ionizing radiation; IEA:Ensembl.
# GO_process	GO:0010949	negative regulation of intestinal phytosterol absorption; IMP:BHF-UCL.
# GO_process	GO:0015918	sterol transport; TAS:Reactome.
# GO_process	GO:0030299	intestinal cholesterol absorption; IC:BHF-UCL.
# GO_process	GO:0033344	cholesterol efflux; IGI:BHF-UCL.
# GO_process	GO:0042493	response to drug; IEA:Ensembl.
# GO_process	GO:0042632	cholesterol homeostasis; IMP:BHF-UCL.
# GO_process	GO:0045796	negative regulation of intestinal cholesterol absorption; IMP:BHF-UCL.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 1.
# Genevisible	Q9H222	HS
# HGNC	HGNC:13886	ABCG5
# INTERACTION	ABCG5_HUMAN	Q9H221 ABCG8; NbExp=2; IntAct=EBI-1761423, EBI-3908684; P16333 NCK1; NbExp=2; IntAct=EBI-1761423, EBI-389883; 
# IntAct	Q9H222	5
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR013525	ABC_2_trans
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Disease	H00152	[Inherited metabolic disease; Cardiovascular disease] Sitosterolemia
# KEGG_Pathway	ko02010	ABC transporters
# KEGG_Pathway	ko04975	Fat digestion and absorption
# KEGG_Pathway	ko04976	Bile secretion
# MIM	210250	phenotype
# MIM	605459	gene
# Organism	ABCG5_HUMAN	Homo sapiens (Human)
# Orphanet	2882	Sitosterolemia
# PDB	5DO7	X-ray; 3.93 A; A/C=1-651
# PROSITE	PS50893	ABC_TRANSPORTER_2
# Pfam	PF00005	ABC_tran
# Pfam	PF01061	ABC2_membrane
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-1369062	ABC transporters in lipid homeostasis
# Reactome	R-HSA-265473	Trafficking of dietary sterols
# RecName	ABCG5_HUMAN	ATP-binding cassette sub-family G member 5
# RefSeq	NP_071881	NM_022436.2. [Q9H222-1]
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 ABC transmembrane type-2 domain. {ECO	0000305}. 
# SIMILARITY	Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA
# SUBCELLULAR LOCATION	ABCG5_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUBUNIT	ABCG5_HUMAN	May form heterodimers with ABCG8 or be tightly coupled to ABCG8 along a pathway regulating diatery-sterol absorption and excretion. 
# SUPFAM	SSF52540	SSF52540
# TCDB	3.A.1.204	the atp-binding cassette (abc) superfamily
# TISSUE SPECIFICITY	ABCG5_HUMAN	Strongly expressed in the liver, lower levels in the small intestine and colon. 
# UCSC	uc002rtn	human. [Q9H222-1]
# WEB RESOURCE	ABCG5_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=Q9H222";
# eggNOG	COG1131	LUCA
# eggNOG	KOG0061	Eukaryota
BLAST	swissprot:ABCG5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCG5_HUMAN
BioCyc	ZFISH:ENSG00000138075-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000138075-MONOMER
COXPRESdb	64240	http://coxpresdb.jp/data/gene/64240.shtml
CleanEx	HS_ABCG5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCG5
DIP	DIP-42630N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-42630N
DOI	10.1002/humu.1206	http://dx.doi.org/10.1002/humu.1206
DOI	10.1038/83799	http://dx.doi.org/10.1038/83799
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1086/321294	http://dx.doi.org/10.1086/321294
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.290.5497.1771	http://dx.doi.org/10.1126/science.290.5497.1771
DrugBank	DB00973	http://www.drugbank.ca/drugs/DB00973
EMBL	AC011242	http://www.ebi.ac.uk/ena/data/view/AC011242
EMBL	AC108476	http://www.ebi.ac.uk/ena/data/view/AC108476
EMBL	AF312715	http://www.ebi.ac.uk/ena/data/view/AF312715
EMBL	AF320293	http://www.ebi.ac.uk/ena/data/view/AF320293
EMBL	AF404106	http://www.ebi.ac.uk/ena/data/view/AF404106
EMBL	AF404107	http://www.ebi.ac.uk/ena/data/view/AF404107
EMBL	BC111541	http://www.ebi.ac.uk/ena/data/view/BC111541
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
Ensembl	ENST00000260645	http://www.ensembl.org/id/ENST00000260645
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0043190	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190
GO_component	GO:0043235	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043235
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0017127	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017127
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GO_function	GO:0046982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046982
GO_process	GO:0007584	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007584
GO_process	GO:0007588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007588
GO_process	GO:0010212	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010212
GO_process	GO:0010949	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010949
GO_process	GO:0015918	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015918
GO_process	GO:0030299	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030299
GO_process	GO:0033344	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033344
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0042632	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042632
GO_process	GO:0045796	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045796
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCG5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCG5
GeneID	64240	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64240
GeneTree	ENSGT00740000114855	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00740000114855
HGNC	HGNC:13886	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13886
HOGENOM	HOG000033763	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000033763&db=HOGENOM6
HOVERGEN	HBG050443	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050443&db=HOVERGEN
HPA	HPA016514	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA016514
InParanoid	Q9H222	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9H222
IntAct	Q9H222	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9H222*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR013525	http://www.ebi.ac.uk/interpro/entry/IPR013525
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	64240	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=64240
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Disease	H00152	http://www.genome.jp/dbget-bin/www_bget?H00152
KEGG_Gene	hsa:64240	http://www.genome.jp/dbget-bin/www_bget?hsa:64240
KEGG_Orthology	KO:K05683	http://www.genome.jp/dbget-bin/www_bget?KO:K05683
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
KEGG_Pathway	ko04975	http://www.genome.jp/kegg-bin/show_pathway?ko04975
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
MIM	210250	http://www.ncbi.nlm.nih.gov/omim/210250
MIM	605459	http://www.ncbi.nlm.nih.gov/omim/605459
MINT	MINT-2840498	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-2840498
OMA	ICHKTLE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ICHKTLE
Orphanet	2882	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=2882
OrthoDB	EOG091G0FOJ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0FOJ
PDB	5DO7	http://www.ebi.ac.uk/pdbe-srv/view/entry/5DO7
PDBsum	5DO7	http://www.ebi.ac.uk/pdbsum/5DO7
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PSORT	swissprot:ABCG5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCG5_HUMAN
PSORT-B	swissprot:ABCG5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCG5_HUMAN
PSORT2	swissprot:ABCG5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCG5_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF01061	http://pfam.xfam.org/family/PF01061
PharmGKB	PA24411	http://www.pharmgkb.org/do/serve?objId=PA24411&objCls=Gene
Phobius	swissprot:ABCG5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCG5_HUMAN
PhylomeDB	Q9H222	http://phylomedb.org/?seqid=Q9H222
ProteinModelPortal	Q9H222	http://www.proteinmodelportal.org/query/uniprot/Q9H222
PubMed	11099417	http://www.ncbi.nlm.nih.gov/pubmed/11099417
PubMed	11138003	http://www.ncbi.nlm.nih.gov/pubmed/11138003
PubMed	11452359	http://www.ncbi.nlm.nih.gov/pubmed/11452359
PubMed	11590207	http://www.ncbi.nlm.nih.gov/pubmed/11590207
PubMed	11668628	http://www.ncbi.nlm.nih.gov/pubmed/11668628
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
Reactome	R-HSA-1369062	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1369062
Reactome	R-HSA-265473	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-265473
RefSeq	NP_071881	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_071881
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	Q9H222	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9H222
STRING	9606.ENSP00000260645	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000260645&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TCDB	3.A.1.204	http://www.tcdb.org/search/result.php?tc=3.A.1.204
UCSC	uc002rtn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002rtn&org=rat
UniGene	Hs.132992	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.132992
UniProtKB	ABCG5_HUMAN	http://www.uniprot.org/uniprot/ABCG5_HUMAN
UniProtKB-AC	Q9H222	http://www.uniprot.org/uniprot/Q9H222
charge	swissprot:ABCG5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCG5_HUMAN
eggNOG	COG1131	http://eggnogapi.embl.de/nog_data/html/tree/COG1131
eggNOG	KOG0061	http://eggnogapi.embl.de/nog_data/html/tree/KOG0061
epestfind	swissprot:ABCG5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCG5_HUMAN
garnier	swissprot:ABCG5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCG5_HUMAN
helixturnhelix	swissprot:ABCG5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCG5_HUMAN
hmoment	swissprot:ABCG5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCG5_HUMAN
iep	swissprot:ABCG5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCG5_HUMAN
inforesidue	swissprot:ABCG5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCG5_HUMAN
neXtProt	NX_Q9H222	http://www.nextprot.org/db/entry/NX_Q9H222
octanol	swissprot:ABCG5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCG5_HUMAN
pepcoil	swissprot:ABCG5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCG5_HUMAN
pepdigest	swissprot:ABCG5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCG5_HUMAN
pepinfo	swissprot:ABCG5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCG5_HUMAN
pepnet	swissprot:ABCG5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCG5_HUMAN
pepstats	swissprot:ABCG5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCG5_HUMAN
pepwheel	swissprot:ABCG5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCG5_HUMAN
pepwindow	swissprot:ABCG5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCG5_HUMAN
sigcleave	swissprot:ABCG5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCG5_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AP3S2_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P59780-1; Sequence=Displayed; Name=C15orf38-AP3S2; IsoId=Q7Z6K5-2; Sequence=External; Note=Based on a naturally occurring readthrough transcript which produces a C15orf38-AP3S2 fusion protein.; Name=3; IsoId=P59780-2; Sequence=VSP_053673, VSP_053674; Note=No experimental confirmation available.; 
# AltName	AP3S2_HUMAN	AP-3 complex subunit sigma-3B
# AltName	AP3S2_HUMAN	Adaptor-related protein complex 3 subunit sigma-2
# AltName	AP3S2_HUMAN	Sigma-3B-adaptin
# AltName	AP3S2_HUMAN	Sigma-adaptin 3b
# BioGrid	115533	12
# CCDS	CCDS10357	-. [P59780-1]
# ChiTaRS	AP3S2	human
# Ensembl	ENST00000336418	ENSP00000338777; ENSG00000157823. [P59780-1]
# Ensembl	ENST00000423566	ENSP00000394170; ENSG00000157823. [P59780-2]
# Ensembl	ENST00000560251	ENSP00000453288; ENSG00000157823. [P59780-2]
# ExpressionAtlas	P59780	baseline and differential
# FUNCTION	AP3S2_HUMAN	Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. 
# GO_component	GO:0005794	Golgi apparatus; TAS:ProtInc.
# GO_component	GO:0030123	AP-3 adaptor complex; IDA:FlyBase.
# GO_component	GO:0030659	cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_component	GO:1904115	axon cytoplasm; IEA:GOC.
# GO_function	GO:0008565	protein transporter activity; IEA:InterPro.
# GO_process	GO:0006886	intracellular protein transport; TAS:ProtInc.
# GO_process	GO:0008089	anterograde axonal transport; ISS:UniProtKB.
# GO_process	GO:0048490	anterograde synaptic vesicle transport; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0030705	cytoskeleton-dependent intracellular transport
# Genevisible	P59780	HS
# HGNC	HGNC:571	AP3S2
# IntAct	P59780	2
# InterPro	IPR000804	Clathrin_sm-chain_CS
# InterPro	IPR011012	Longin-like_dom
# InterPro	IPR016635	AP_complex_ssu
# InterPro	IPR022775	AP_mu_sigma_su
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Pathway	ko04142	Lysosome
# MIM	602416	gene
# Organism	AP3S2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11753	PTHR11753
# PROSITE	PS00989	CLAT_ADAPTOR_S
# Pfam	PF01217	Clat_adaptor_s
# Proteomes	UP000005640	Chromosome 15
# RecName	AP3S2_HUMAN	AP-3 complex subunit sigma-2
# RefSeq	NP_005820	NM_005829.4. [P59780-1]
# SIMILARITY	Belongs to the adaptor complexes small subunit family. {ECO	0000305}.
# SUBCELLULAR LOCATION	AP3S2_HUMAN	Golgi apparatus. Cytoplasmic vesicle membrane {ECO 0000250}; Peripheral membrane protein {ECO 0000250}; Cytoplasmic side {ECO 0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO 0000250}. 
# SUBUNIT	Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta- type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2). Interacts with AGAP1. AP-3 associates with the BLOC-1 complex (By similarity). {ECO	0000250}. 
# SUPFAM	SSF64356	SSF64356
# TISSUE SPECIFICITY	Present in all adult tissues examined. {ECO:0000269|PubMed	9118953}. 
# UCSC	uc002boq	human. [P59780-1]
# eggNOG	COG5030	LUCA
# eggNOG	KOG0936	Eukaryota
BLAST	swissprot:AP3S2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AP3S2_HUMAN
BioCyc	ZFISH:G66-31962-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31962-MONOMER
COXPRESdb	10239	http://coxpresdb.jp/data/gene/10239.shtml
CleanEx	HS_AP3S2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AP3S2
DOI	10.1038/nature04601	http://dx.doi.org/10.1038/nature04601
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/emboj/16.5.917	http://dx.doi.org/10.1093/emboj/16.5.917
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC018988	http://www.ebi.ac.uk/ena/data/view/AC018988
EMBL	AC027176	http://www.ebi.ac.uk/ena/data/view/AC027176
EMBL	AK222698	http://www.ebi.ac.uk/ena/data/view/AK222698
EMBL	AK294712	http://www.ebi.ac.uk/ena/data/view/AK294712
EMBL	AK312467	http://www.ebi.ac.uk/ena/data/view/AK312467
EMBL	BC002785	http://www.ebi.ac.uk/ena/data/view/BC002785
EMBL	BC010020	http://www.ebi.ac.uk/ena/data/view/BC010020
EMBL	CH471101	http://www.ebi.ac.uk/ena/data/view/CH471101
EMBL	X99459	http://www.ebi.ac.uk/ena/data/view/X99459
Ensembl	ENST00000336418	http://www.ensembl.org/id/ENST00000336418
Ensembl	ENST00000423566	http://www.ensembl.org/id/ENST00000423566
Ensembl	ENST00000560251	http://www.ensembl.org/id/ENST00000560251
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0030123	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030123
GO_component	GO:0030659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030659
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_component	GO:1904115	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1904115
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0006886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006886
GO_process	GO:0008089	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008089
GO_process	GO:0048490	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048490
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0030705	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030705
GeneCards	AP3S2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=AP3S2
GeneID	10239	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10239
GeneTree	ENSGT00550000074761	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074761
HGNC	HGNC:571	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:571
HOGENOM	HOG000185228	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000185228&db=HOGENOM6
HOVERGEN	HBG050517	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050517&db=HOVERGEN
HPA	HPA049270	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA049270
InParanoid	P59780	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P59780
IntAct	P59780	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P59780*
InterPro	IPR000804	http://www.ebi.ac.uk/interpro/entry/IPR000804
InterPro	IPR011012	http://www.ebi.ac.uk/interpro/entry/IPR011012
InterPro	IPR016635	http://www.ebi.ac.uk/interpro/entry/IPR016635
InterPro	IPR022775	http://www.ebi.ac.uk/interpro/entry/IPR022775
Jabion	10239	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10239
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Gene	hsa:10239	http://www.genome.jp/dbget-bin/www_bget?hsa:10239
KEGG_Orthology	KO:K12399	http://www.genome.jp/dbget-bin/www_bget?KO:K12399
KEGG_Pathway	ko04142	http://www.genome.jp/kegg-bin/show_pathway?ko04142
MIM	602416	http://www.ncbi.nlm.nih.gov/omim/602416
PANTHER	PTHR11753	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11753
PROSITE	PS00989	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00989
PSORT	swissprot:AP3S2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AP3S2_HUMAN
PSORT-B	swissprot:AP3S2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AP3S2_HUMAN
PSORT2	swissprot:AP3S2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AP3S2_HUMAN
Pfam	PF01217	http://pfam.xfam.org/family/PF01217
PharmGKB	PA24863	http://www.pharmgkb.org/do/serve?objId=PA24863&objCls=Gene
Phobius	swissprot:AP3S2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AP3S2_HUMAN
PhylomeDB	P59780	http://phylomedb.org/?seqid=P59780
ProteinModelPortal	P59780	http://www.proteinmodelportal.org/query/uniprot/P59780
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16572171	http://www.ncbi.nlm.nih.gov/pubmed/16572171
PubMed	9118953	http://www.ncbi.nlm.nih.gov/pubmed/9118953
RefSeq	NP_005820	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005820
SMR	P59780	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P59780
STRING	9606.ENSP00000338777	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000338777&targetmode=cogs
SUPFAM	SSF64356	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF64356
UCSC	uc002boq	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002boq&org=rat
UniGene	Hs.632161	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.632161
UniProtKB	AP3S2_HUMAN	http://www.uniprot.org/uniprot/AP3S2_HUMAN
UniProtKB-AC	P59780	http://www.uniprot.org/uniprot/P59780
charge	swissprot:AP3S2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AP3S2_HUMAN
eggNOG	COG5030	http://eggnogapi.embl.de/nog_data/html/tree/COG5030
eggNOG	KOG0936	http://eggnogapi.embl.de/nog_data/html/tree/KOG0936
epestfind	swissprot:AP3S2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AP3S2_HUMAN
garnier	swissprot:AP3S2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AP3S2_HUMAN
helixturnhelix	swissprot:AP3S2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AP3S2_HUMAN
hmoment	swissprot:AP3S2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AP3S2_HUMAN
iep	swissprot:AP3S2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AP3S2_HUMAN
inforesidue	swissprot:AP3S2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AP3S2_HUMAN
neXtProt	NX_P59780	http://www.nextprot.org/db/entry/NX_P59780
octanol	swissprot:AP3S2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AP3S2_HUMAN
pepcoil	swissprot:AP3S2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AP3S2_HUMAN
pepdigest	swissprot:AP3S2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AP3S2_HUMAN
pepinfo	swissprot:AP3S2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AP3S2_HUMAN
pepnet	swissprot:AP3S2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AP3S2_HUMAN
pepstats	swissprot:AP3S2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AP3S2_HUMAN
pepwheel	swissprot:AP3S2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AP3S2_HUMAN
pepwindow	swissprot:AP3S2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AP3S2_HUMAN
sigcleave	swissprot:AP3S2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AP3S2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S13A5_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q86YT5-1; Sequence=Displayed; Name=2; IsoId=Q86YT5-2; Sequence=VSP_043098; Note=No experimental confirmation available.; Name=3; IsoId=Q86YT5-3; Sequence=VSP_054910; Note=No experimental confirmation available.; Name=4; IsoId=Q86YT5-4; Sequence=VSP_055652; Note=No experimental confirmation available.; 
# AltName	S13A5_HUMAN	Na(+)/citrate cotransporter
# AltName	S13A5_HUMAN	Sodium-coupled citrate transporter
# AltName	S13A5_HUMAN	Sodium-dependent citrate transporter
# CCDS	CCDS11079	-. [Q86YT5-1]
# CCDS	CCDS45593	-. [Q86YT5-2]
# CCDS	CCDS67136	-. [Q86YT5-4]
# CCDS	CCDS67137	-. [Q86YT5-3]
# Ensembl	ENST00000293800	ENSP00000293800; ENSG00000141485. [Q86YT5-3]
# Ensembl	ENST00000381074	ENSP00000370464; ENSG00000141485. [Q86YT5-4]
# Ensembl	ENST00000433363	ENSP00000406220; ENSG00000141485. [Q86YT5-1]
# Ensembl	ENST00000573648	ENSP00000459372; ENSG00000141485. [Q86YT5-2]
# ExpressionAtlas	Q86YT5	baseline and differential
# FUNCTION	S13A5_HUMAN	High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol. {ECO 0000269|PubMed 12445824}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0015137	citrate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015141	succinate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015142	tricarboxylic acid transmembrane transporter activity; IEA:Ensembl.
# GO_function	S13A5_HUMAN	GO 0017153 sodium dicarboxylate symporter activity; IBA GO_Central.
# GO_process	GO:0015746	citrate transport; IBA:GO_Central.
# GO_process	GO:0035674	tricarboxylic acid transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q86YT5	HS
# HGNC	HGNC:23089	SLC13A5
# IntAct	Q86YT5	11
# InterPro	IPR001898	Na/sul_symport
# InterPro	IPR031312	Na/sul_symport_CS
# KEGG_Brite	ko02001	Solute carrier family
# MIM	608305	gene
# Organism	S13A5_HUMAN	Homo sapiens (Human)
# Orphanet	1934	Early infantile epileptic encephalopathy
# PROSITE	PS01271	NA_SULFATE
# Pfam	PF00939	Na_sulph_symp
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-433137	Sodium-coupled sulphate, di- and tri-carboxylate transporters
# RecName	S13A5_HUMAN	Solute carrier family 13 member 5
# RefSeq	NP_001137310	NM_001143838.2. [Q86YT5-2]
# RefSeq	NP_001271438	NM_001284509.1. [Q86YT5-3]
# RefSeq	NP_001271439	NM_001284510.1. [Q86YT5-4]
# RefSeq	NP_808218	NM_177550.4. [Q86YT5-1]
# SIMILARITY	Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	S13A5_HUMAN	Membrane; Multi-pass membrane protein. 
# TCDB	2.A.47.1:the divalent anion	na(+) symporter (dass) family
# TISSUE SPECIFICITY	Expressed most predominantly in the liver, with moderate expression detectable in the brain and testis. {ECO:0000269|PubMed	12445824}. 
# UCSC	uc002gdj	human. [Q86YT5-1]
# eggNOG	COG0471	LUCA
# eggNOG	KOG1281	Eukaryota
BLAST	swissprot:S13A5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S13A5_HUMAN
COG	COG0471	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0471
COXPRESdb	284111	http://coxpresdb.jp/data/gene/284111.shtml
CleanEx	HS_SLC13A5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC13A5
DOI	10.1016/S0006-291X(02)02669-4	http://dx.doi.org/10.1016/S0006-291X(02)02669-4
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC004706	http://www.ebi.ac.uk/ena/data/view/AC004706
EMBL	AK127797	http://www.ebi.ac.uk/ena/data/view/AK127797
EMBL	AK172785	http://www.ebi.ac.uk/ena/data/view/AK172785
EMBL	AK297612	http://www.ebi.ac.uk/ena/data/view/AK297612
EMBL	AY151833	http://www.ebi.ac.uk/ena/data/view/AY151833
EMBL	BC104795	http://www.ebi.ac.uk/ena/data/view/BC104795
EMBL	BC112151	http://www.ebi.ac.uk/ena/data/view/BC112151
EMBL	BC143689	http://www.ebi.ac.uk/ena/data/view/BC143689
EMBL	CH471108	http://www.ebi.ac.uk/ena/data/view/CH471108
Ensembl	ENST00000293800	http://www.ensembl.org/id/ENST00000293800
Ensembl	ENST00000381074	http://www.ensembl.org/id/ENST00000381074
Ensembl	ENST00000433363	http://www.ensembl.org/id/ENST00000433363
Ensembl	ENST00000573648	http://www.ensembl.org/id/ENST00000573648
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0015137	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015137
GO_function	GO:0015141	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015141
GO_function	GO:0015142	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015142
GO_function	GO:0017153	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017153
GO_process	GO:0015746	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015746
GO_process	GO:0035674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035674
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC13A5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC13A5
GeneID	284111	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=284111
GeneTree	ENSGT00550000074480	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074480
HGNC	HGNC:23089	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:23089
HOGENOM	HOG000278432	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278432&db=HOGENOM6
HOVERGEN	HBG055339	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG055339&db=HOVERGEN
HPA	HPA044343	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA044343
HPA	HPA057088	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA057088
InParanoid	Q86YT5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q86YT5
IntAct	Q86YT5	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q86YT5*
InterPro	IPR001898	http://www.ebi.ac.uk/interpro/entry/IPR001898
InterPro	IPR031312	http://www.ebi.ac.uk/interpro/entry/IPR031312
Jabion	284111	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=284111
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:284111	http://www.genome.jp/dbget-bin/www_bget?hsa:284111
KEGG_Orthology	KO:K14445	http://www.genome.jp/dbget-bin/www_bget?KO:K14445
MIM	608305	http://www.ncbi.nlm.nih.gov/omim/608305
OMA	FFANHWK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FFANHWK
Orphanet	1934	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1934
OrthoDB	EOG091G092X	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G092X
PROSITE	PS01271	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01271
PSORT	swissprot:S13A5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S13A5_HUMAN
PSORT-B	swissprot:S13A5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S13A5_HUMAN
PSORT2	swissprot:S13A5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S13A5_HUMAN
Pfam	PF00939	http://pfam.xfam.org/family/PF00939
PharmGKB	PA134950956	http://www.pharmgkb.org/do/serve?objId=PA134950956&objCls=Gene
Phobius	swissprot:S13A5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S13A5_HUMAN
PhylomeDB	Q86YT5	http://phylomedb.org/?seqid=Q86YT5
ProteinModelPortal	Q86YT5	http://www.proteinmodelportal.org/query/uniprot/Q86YT5
PubMed	12445824	http://www.ncbi.nlm.nih.gov/pubmed/12445824
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
Reactome	R-HSA-433137	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-433137
RefSeq	NP_001137310	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001137310
RefSeq	NP_001271438	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001271438
RefSeq	NP_001271439	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001271439
RefSeq	NP_808218	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_808218
STRING	9606.ENSP00000406220	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000406220&targetmode=cogs
STRING	COG0471	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0471&targetmode=cogs
TCDB	2.A.47.1	http://www.tcdb.org/search/result.php?tc=2.A.47.1
UCSC	uc002gdj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002gdj&org=rat
UniGene	Hs.399496	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.399496
UniProtKB	S13A5_HUMAN	http://www.uniprot.org/uniprot/S13A5_HUMAN
UniProtKB-AC	Q86YT5	http://www.uniprot.org/uniprot/Q86YT5
charge	swissprot:S13A5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S13A5_HUMAN
eggNOG	COG0471	http://eggnogapi.embl.de/nog_data/html/tree/COG0471
eggNOG	KOG1281	http://eggnogapi.embl.de/nog_data/html/tree/KOG1281
epestfind	swissprot:S13A5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S13A5_HUMAN
garnier	swissprot:S13A5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S13A5_HUMAN
helixturnhelix	swissprot:S13A5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S13A5_HUMAN
hmoment	swissprot:S13A5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S13A5_HUMAN
iep	swissprot:S13A5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S13A5_HUMAN
inforesidue	swissprot:S13A5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S13A5_HUMAN
neXtProt	NX_Q86YT5	http://www.nextprot.org/db/entry/NX_Q86YT5
octanol	swissprot:S13A5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S13A5_HUMAN
pepcoil	swissprot:S13A5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S13A5_HUMAN
pepdigest	swissprot:S13A5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S13A5_HUMAN
pepinfo	swissprot:S13A5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S13A5_HUMAN
pepnet	swissprot:S13A5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S13A5_HUMAN
pepstats	swissprot:S13A5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S13A5_HUMAN
pepwheel	swissprot:S13A5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S13A5_HUMAN
pepwindow	swissprot:S13A5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S13A5_HUMAN
sigcleave	swissprot:S13A5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S13A5_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	119574	8
# ChiTaRS	C11orf73	human
# DISEASE	HIKES_HUMAN	Leukodystrophy, hypomyelinating, 13 (HLD13) [MIM 616881]  An autosomal recessive neurodegenerative disorder with infantile onset, affecting mainly the central white matter. Clinical features include early feeding difficulties, global developmental delay, postnatal progressive microcephaly, truncal hypotonia, spasticity, and variable neurologic deficits, such as visual impairment. {ECO 0000269|PubMed 26545878}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000278483	ENSP00000278483; ENSG00000149196
# ExpressionAtlas	Q53FT3	baseline and differential
# FUNCTION	HIKES_HUMAN	Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress  acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus. {ECO 0000269|PubMed 22541429}. 
# GO_component	GO:0005622	intracellular; IDA:UniProtKB.
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005654	nucleoplasm; TAS:Reactome.
# GO_component	GO:0005829	cytosol; IDA:UniProtKB.
# GO_component	GO:0030054	cell junction; IDA:HPA.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0008565	protein transporter activity; IDA:UniProtKB.
# GO_function	GO:0030544	Hsp70 protein binding; IDA:UniProtKB.
# GO_process	GO:0006606	protein import into nucleus; IDA:UniProtKB.
# GO_process	GO:0015031	protein transport; IDA:UniProtKB.
# GO_process	GO:0034605	cellular response to heat; IDA:UniProtKB.
# GO_process	GO:1900034	regulation of cellular response to heat; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005622	intracellular
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q53FT3	HS
# HGNC	HGNC:26938	HIKESHI
# INDUCTION	Following heat-shock treatment. {ECO:0000269|PubMed	22541429}. 
# IntAct	Q53FT3	5
# InterPro	IPR008493	DUF775
# InterPro	IPR031318	OPI10
# MIM	614908	gene
# MIM	616881	phenotype
# MISCELLANEOUS	'Hikeshi' is a traditional Japanese compound word used for a firefighter, smokejumper, or troubleshooter. {ECO:0000305|PubMed	22541429}. 
# Organism	HIKES_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12925:SF0	PTHR12925:SF0
# PDB	3WVZ	X-ray; 1.88 A; A/B=1-197
# PDB	3WW0	X-ray; 2.50 A; A/B=1-197
# Pfam	PF05603	DUF775
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-3371453	Regulation of HSF1-mediated heat shock response
# RecName	HIKES_HUMAN	Protein Hikeshi
# RefSeq	NP_057485	NM_016401.3
# SEQUENCE CAUTION	Sequence=AAF29102.1; Type=Frameshift; Positions=62, 68; Evidence={ECO:0000305}; Sequence=AAF29142.1; Type=Frameshift; Positions=9, 57; Evidence={ECO	0000305}; Sequence=AAF36168.1; Type=Frameshift; Positions=67; Evidence={ECO:0000305};
# SIMILARITY	Belongs to the OPI10 family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	HIKES_HUMAN	Cytoplasm, cytosol {ECO 0000269|PubMed 22541429}. Nucleus {ECO 0000269|PubMed 22541429}. 
# SUBUNIT	Interacts with ATP-bound HSP70 proteins. Interacts with NUP62 and NUP153 (via F-X-F-G repeats). {ECO:0000269|PubMed	22541429}. 
# UCSC	uc001pbu	human
# eggNOG	ENOG4111H6N	LUCA
# eggNOG	KOG4067	Eukaryota
BLAST	swissprot:HIKES_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:HIKES_HUMAN
COXPRESdb	51501	http://coxpresdb.jp/data/gene/51501.shtml
CleanEx	HS_C11orf73	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_C11orf73
DOI	10.1016/j.cell.2012.02.058	http://dx.doi.org/10.1016/j.cell.2012.02.058
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1101/gr.140200	http://dx.doi.org/10.1101/gr.140200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1136/jmedgenet-2015-103232	http://dx.doi.org/10.1136/jmedgenet-2015-103232
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF151082	http://www.ebi.ac.uk/ena/data/view/AF151082
EMBL	AF161487	http://www.ebi.ac.uk/ena/data/view/AF161487
EMBL	AF161527	http://www.ebi.ac.uk/ena/data/view/AF161527
EMBL	AK001447	http://www.ebi.ac.uk/ena/data/view/AK001447
EMBL	AK223198	http://www.ebi.ac.uk/ena/data/view/AK223198
EMBL	BC001677	http://www.ebi.ac.uk/ena/data/view/BC001677
EMBL	BC006476	http://www.ebi.ac.uk/ena/data/view/BC006476
EMBL	BC015991	http://www.ebi.ac.uk/ena/data/view/BC015991
EMBL	BC018080	http://www.ebi.ac.uk/ena/data/view/BC018080
EMBL	BC021621	http://www.ebi.ac.uk/ena/data/view/BC021621
Ensembl	ENST00000278483	http://www.ensembl.org/id/ENST00000278483
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0030544	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030544
GO_process	GO:0006606	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006606
GO_process	GO:0015031	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031
GO_process	GO:0034605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034605
GO_process	GO:1900034	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900034
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	C11orf73	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=C11orf73
GeneID	51501	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51501
GeneTree	ENSGT00390000004056	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000004056
HGNC	HGNC:26938	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:26938
HOGENOM	HOG000175561	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000175561&db=HOGENOM6
HOVERGEN	HBG081226	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG081226&db=HOVERGEN
HPA	HPA035063	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035063
HPA	HPA035064	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035064
InParanoid	Q53FT3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q53FT3
IntAct	Q53FT3	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q53FT3*
InterPro	IPR008493	http://www.ebi.ac.uk/interpro/entry/IPR008493
InterPro	IPR031318	http://www.ebi.ac.uk/interpro/entry/IPR031318
Jabion	51501	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=51501
KEGG_Gene	hsa:51501	http://www.genome.jp/dbget-bin/www_bget?hsa:51501
MIM	614908	http://www.ncbi.nlm.nih.gov/omim/614908
MIM	616881	http://www.ncbi.nlm.nih.gov/omim/616881
MINT	MINT-3047121	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3047121
OMA	QFGQRML	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QFGQRML
OrthoDB	EOG091G0LVQ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0LVQ
PANTHER	PTHR12925:SF0	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12925:SF0
PDB	3WVZ	http://www.ebi.ac.uk/pdbe-srv/view/entry/3WVZ
PDB	3WW0	http://www.ebi.ac.uk/pdbe-srv/view/entry/3WW0
PDBsum	3WVZ	http://www.ebi.ac.uk/pdbsum/3WVZ
PDBsum	3WW0	http://www.ebi.ac.uk/pdbsum/3WW0
PSORT	swissprot:HIKES_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:HIKES_HUMAN
PSORT-B	swissprot:HIKES_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:HIKES_HUMAN
PSORT2	swissprot:HIKES_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:HIKES_HUMAN
Pfam	PF05603	http://pfam.xfam.org/family/PF05603
PharmGKB	PA144596492	http://www.pharmgkb.org/do/serve?objId=PA144596492&objCls=Gene
Phobius	swissprot:HIKES_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:HIKES_HUMAN
PhylomeDB	Q53FT3	http://phylomedb.org/?seqid=Q53FT3
ProteinModelPortal	Q53FT3	http://www.proteinmodelportal.org/query/uniprot/Q53FT3
PubMed	11042152	http://www.ncbi.nlm.nih.gov/pubmed/11042152
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22541429	http://www.ncbi.nlm.nih.gov/pubmed/22541429
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	26545878	http://www.ncbi.nlm.nih.gov/pubmed/26545878
Reactome	R-HSA-3371453	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3371453
RefSeq	NP_057485	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_057485
SMR	Q53FT3	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q53FT3
STRING	9606.ENSP00000278483	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000278483&targetmode=cogs
UCSC	uc001pbu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001pbu&org=rat
UniGene	Hs.283322	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.283322
UniProtKB	HIKES_HUMAN	http://www.uniprot.org/uniprot/HIKES_HUMAN
UniProtKB-AC	Q53FT3	http://www.uniprot.org/uniprot/Q53FT3
charge	swissprot:HIKES_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:HIKES_HUMAN
eggNOG	ENOG4111H6N	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111H6N
eggNOG	KOG4067	http://eggnogapi.embl.de/nog_data/html/tree/KOG4067
epestfind	swissprot:HIKES_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:HIKES_HUMAN
garnier	swissprot:HIKES_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:HIKES_HUMAN
helixturnhelix	swissprot:HIKES_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:HIKES_HUMAN
hmoment	swissprot:HIKES_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:HIKES_HUMAN
iep	swissprot:HIKES_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:HIKES_HUMAN
inforesidue	swissprot:HIKES_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:HIKES_HUMAN
neXtProt	NX_Q53FT3	http://www.nextprot.org/db/entry/NX_Q53FT3
octanol	swissprot:HIKES_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:HIKES_HUMAN
pepcoil	swissprot:HIKES_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:HIKES_HUMAN
pepdigest	swissprot:HIKES_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:HIKES_HUMAN
pepinfo	swissprot:HIKES_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:HIKES_HUMAN
pepnet	swissprot:HIKES_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:HIKES_HUMAN
pepstats	swissprot:HIKES_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:HIKES_HUMAN
pepwheel	swissprot:HIKES_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:HIKES_HUMAN
pepwindow	swissprot:HIKES_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:HIKES_HUMAN
sigcleave	swissprot:HIKES_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:HIKES_HUMAN
## Database	ID	URL or Descriptions
# AltName	CXA8_HUMAN	Connexin-50
# AltName	CXA8_HUMAN	Lens fiber protein MP70
# DISEASE	CXA8_HUMAN	Cataract 1, multiple types (CTRCT1) [MIM 116200]  An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. CTRCT1 includes congenital, zonular pulverulent, nuclear progressive, nuclear pulverulent, nuclear total, total, and posterior subcapsular types of cataract. Zonular or lamellar cataracts are opacities, broad or narrow, usually consisting of powdery white dots affecting only certain layers or zones between the cortex and nucleus of an otherwise clear lens. The opacity may be so dense as to render the entire central region of the lens completely opaque, or so translucent that vision is hardly if at all impeded. Zonular cataracts generally do not involve the embryonic nucleus, though sometimes they involve the fetal nucleus. Usually sharply separated from a clear cortex outside them, they may have projections from their outer edges known as riders or spokes. In some cases cataract is associated with microcornea without any other systemic anomaly or dysmorphism. Microcornea is defined by a corneal diameter inferior to 10 mm in both meridians in an otherwise normal eye. {ECO 0000269|PubMed 10480374, ECO 0000269|PubMed 11846744, ECO 0000269|PubMed 14627691, ECO 0000269|PubMed 16234473, ECO 0000269|PubMed 16604058, ECO 0000269|PubMed 18006672, ECO 0000269|PubMed 21174522, ECO 0000269|PubMed 21921990, ECO 0000269|PubMed 23508780, ECO 0000269|PubMed 9497259, ECO 0000269|Ref.4}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000369235	ENSP00000358238; ENSG00000121634
# ExpressionAtlas	P48165	baseline and differential
# FUNCTION	CXA8_HUMAN	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. 
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0005922	connexin complex; TAS:ProtInc.
# GO_function	GO:0005243	gap junction channel activity; IEA:Ensembl.
# GO_function	GO:0015267	channel activity; TAS:ProtInc.
# GO_process	GO:0002088	lens development in camera-type eye; IEA:Ensembl.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007267	cell-cell signaling; IEA:Ensembl.
# GO_process	GO:0007601	visual perception; TAS:ProtInc.
# GO_process	GO:0051260	protein homooligomerization; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# Genevisible	P48165	HS
# HGNC	HGNC:4281	GJA8
# InterPro	IPR000500	Connexin
# InterPro	IPR002266	Connexin50
# InterPro	IPR013092	Connexin_N
# InterPro	IPR017990	Connexin_CS
# InterPro	IPR019570	Connexin_CCC
# KEGG_Disease	H01202	[Eye disease] Cataract
# MIM	116200	phenotype
# MIM	600897	gene
# Organism	CXA8_HUMAN	Homo sapiens (Human)
# Orphanet	1377	Cataract-microcornea syndrome
# Orphanet	98984	Pulverulent cataract
# PANTHER	PTHR11984	PTHR11984; 2
# PANTHER	PTHR11984:SF19	PTHR11984:SF19; 2
# PIR	I39176	I39176
# PRINTS	PR00206	CONNEXIN
# PRINTS	PR01137	CONNEXINA8
# PROSITE	PS00407	CONNEXINS_1
# PROSITE	PS00408	CONNEXINS_2
# Pfam	PF00029	Connexin
# Pfam	PF03509	Connexin50
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-190861	Gap junction assembly
# RecName	CXA8_HUMAN	Gap junction alpha-8 protein
# RefSeq	NP_005258	NM_005267.4
# RefSeq	XP_011507718	XM_011509416.1
# SIMILARITY	Belongs to the connexin family. Alpha-type (group II) subfamily. {ECO	0000305}. 
# SMART	SM00037	CNX
# SMART	SM01089	Connexin_CCC
# SUBCELLULAR LOCATION	CXA8_HUMAN	Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. 
# SUBUNIT	CXA8_HUMAN	A connexon is composed of a hexamer of connexins. This particular connexin only forms junctional channels. 
# TCDB	1.A.24.1	the gap junction-forming connexin (connexin) family
# TISSUE SPECIFICITY	CXA8_HUMAN	Eye lens. 
# WEB RESOURCE	CXA8_HUMAN	Name=Eye disease Gap junction protein, alpha 8 (GJA8); Note=Leiden Open Variation Database (LOVD); URL="http //www.lovd.nl/GJA8";
# eggNOG	ENOG410IF3Z	Eukaryota
# eggNOG	ENOG410ZC96	LUCA
BLAST	swissprot:CXA8_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CXA8_HUMAN
BioCyc	ZFISH:ENSG00000121634-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000121634-MONOMER
COXPRESdb	2703	http://coxpresdb.jp/data/gene/2703.shtml
CleanEx	HS_GJA8	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GJA8
DOI	10.1007/s00439-013-1289-0	http://dx.doi.org/10.1007/s00439-013-1289-0
DOI	10.1007/s004399900094	http://dx.doi.org/10.1007/s004399900094
DOI	10.1034/j.1399-0004.2001.600614.x	http://dx.doi.org/10.1034/j.1399-0004.2001.600614.x
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1086/301762	http://dx.doi.org/10.1086/301762
DOI	10.1136/bjo.2005.075184	http://dx.doi.org/10.1136/bjo.2005.075184
DOI	10.1136/jmg.2007.051029	http://dx.doi.org/10.1136/jmg.2007.051029
DOI	10.1136/jmg.40.11.e124	http://dx.doi.org/10.1136/jmg.40.11.e124
DOI	10.3109/13816810.2010.535886	http://dx.doi.org/10.3109/13816810.2010.535886
EMBL	AF217524	http://www.ebi.ac.uk/ena/data/view/AF217524
EMBL	AL445591	http://www.ebi.ac.uk/ena/data/view/AL445591
EMBL	EF672108	http://www.ebi.ac.uk/ena/data/view/EF672108
EMBL	U34802	http://www.ebi.ac.uk/ena/data/view/U34802
Ensembl	ENST00000369235	http://www.ensembl.org/id/ENST00000369235
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005922	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005922
GO_function	GO:0005243	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005243
GO_function	GO:0015267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015267
GO_process	GO:0002088	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002088
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GO_process	GO:0007601	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007601
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	GJA8	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GJA8
GeneID	2703	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2703
GeneTree	ENSGT00840000129674	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00840000129674
HGNC	HGNC:4281	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4281
HOGENOM	HOG000231127	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231127&db=HOGENOM6
HOVERGEN	HBG009576	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG009576&db=HOVERGEN
InParanoid	P48165	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P48165
InterPro	IPR000500	http://www.ebi.ac.uk/interpro/entry/IPR000500
InterPro	IPR002266	http://www.ebi.ac.uk/interpro/entry/IPR002266
InterPro	IPR013092	http://www.ebi.ac.uk/interpro/entry/IPR013092
InterPro	IPR017990	http://www.ebi.ac.uk/interpro/entry/IPR017990
InterPro	IPR019570	http://www.ebi.ac.uk/interpro/entry/IPR019570
Jabion	2703	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2703
KEGG_Disease	H01202	http://www.genome.jp/dbget-bin/www_bget?H01202
KEGG_Gene	hsa:2703	http://www.genome.jp/dbget-bin/www_bget?hsa:2703
KEGG_Orthology	KO:K07617	http://www.genome.jp/dbget-bin/www_bget?KO:K07617
MIM	116200	http://www.ncbi.nlm.nih.gov/omim/116200
MIM	600897	http://www.ncbi.nlm.nih.gov/omim/600897
OMA	MYVGHAV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MYVGHAV
Orphanet	1377	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1377
Orphanet	98984	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98984
OrthoDB	EOG091G0FKH	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0FKH
PANTHER	PTHR11984	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11984
PANTHER	PTHR11984:SF19	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11984:SF19
PRINTS	PR00206	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00206
PRINTS	PR01137	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01137
PROSITE	PS00407	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00407
PROSITE	PS00408	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00408
PSORT	swissprot:CXA8_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CXA8_HUMAN
PSORT-B	swissprot:CXA8_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CXA8_HUMAN
PSORT2	swissprot:CXA8_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CXA8_HUMAN
Pfam	PF00029	http://pfam.xfam.org/family/PF00029
Pfam	PF03509	http://pfam.xfam.org/family/PF03509
PharmGKB	PA28692	http://www.pharmgkb.org/do/serve?objId=PA28692&objCls=Gene
Phobius	swissprot:CXA8_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CXA8_HUMAN
PhylomeDB	P48165	http://phylomedb.org/?seqid=P48165
ProteinModelPortal	P48165	http://www.proteinmodelportal.org/query/uniprot/P48165
PubMed	10480374	http://www.ncbi.nlm.nih.gov/pubmed/10480374
PubMed	11846744	http://www.ncbi.nlm.nih.gov/pubmed/11846744
PubMed	14627691	http://www.ncbi.nlm.nih.gov/pubmed/14627691
PubMed	16234473	http://www.ncbi.nlm.nih.gov/pubmed/16234473
PubMed	16604058	http://www.ncbi.nlm.nih.gov/pubmed/16604058
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	18006672	http://www.ncbi.nlm.nih.gov/pubmed/18006672
PubMed	19756179	http://www.ncbi.nlm.nih.gov/pubmed/19756179
PubMed	21174522	http://www.ncbi.nlm.nih.gov/pubmed/21174522
PubMed	21921990	http://www.ncbi.nlm.nih.gov/pubmed/21921990
PubMed	23508780	http://www.ncbi.nlm.nih.gov/pubmed/23508780
PubMed	7796604	http://www.ncbi.nlm.nih.gov/pubmed/7796604
PubMed	8549164	http://www.ncbi.nlm.nih.gov/pubmed/8549164
PubMed	9497259	http://www.ncbi.nlm.nih.gov/pubmed/9497259
Reactome	R-HSA-190861	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-190861
RefSeq	NP_005258	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005258
RefSeq	XP_011507718	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011507718
SMART	SM00037	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00037
SMART	SM01089	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01089
STRING	9606.ENSP00000240986	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000240986&targetmode=cogs
TCDB	1.A.24.1	http://www.tcdb.org/search/result.php?tc=1.A.24.1
UniGene	Hs.632441	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.632441
UniProtKB	CXA8_HUMAN	http://www.uniprot.org/uniprot/CXA8_HUMAN
UniProtKB-AC	P48165	http://www.uniprot.org/uniprot/P48165
charge	swissprot:CXA8_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CXA8_HUMAN
eggNOG	ENOG410IF3Z	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IF3Z
eggNOG	ENOG410ZC96	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZC96
epestfind	swissprot:CXA8_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CXA8_HUMAN
garnier	swissprot:CXA8_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CXA8_HUMAN
helixturnhelix	swissprot:CXA8_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CXA8_HUMAN
hmoment	swissprot:CXA8_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CXA8_HUMAN
iep	swissprot:CXA8_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CXA8_HUMAN
inforesidue	swissprot:CXA8_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CXA8_HUMAN
neXtProt	NX_P48165	http://www.nextprot.org/db/entry/NX_P48165
octanol	swissprot:CXA8_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CXA8_HUMAN
pepcoil	swissprot:CXA8_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CXA8_HUMAN
pepdigest	swissprot:CXA8_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CXA8_HUMAN
pepinfo	swissprot:CXA8_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CXA8_HUMAN
pepnet	swissprot:CXA8_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CXA8_HUMAN
pepstats	swissprot:CXA8_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CXA8_HUMAN
pepwheel	swissprot:CXA8_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CXA8_HUMAN
pepwindow	swissprot:CXA8_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CXA8_HUMAN
sigcleave	swissprot:CXA8_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CXA8_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SFXN4_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6P4A7-1; Sequence=Displayed; Name=2; IsoId=Q6P4A7-2; Sequence=VSP_014609, VSP_014610; Note=No experimental confirmation available.; Name=3; IsoId=Q6P4A7-3; Sequence=VSP_014608; Note=No experimental confirmation available.; 
# AltName	SFXN4_HUMAN	Breast cancer resistance marker 1
# BioGrid	125645	9
# CCDS	CCDS7610	-. [Q6P4A7-1]
# ChiTaRS	SFXN4	human
# DISEASE	SFXN4_HUMAN	Combined oxidative phosphorylation deficiency 18 (COXPD18) [MIM 615578]  An autosomal recessive disorder of mitochondrial dysfunction characterized by intrauterine growth retardation, hypotonia, visual impairment, speech delay, and lactic acidosis associated with decreased mitochondrial respiratory chain activity. Affected patients may also show hematologic abnormalities, mainly macrocytic anemia. {ECO 0000269|PubMed 24119684}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000355697	ENSP00000347924; ENSG00000183605. [Q6P4A7-1]
# ExpressionAtlas	Q6P4A7	baseline and differential
# FUNCTION	SFXN4_HUMAN	Potential iron transporter. {ECO 0000250}. 
# GO_component	GO:0005743	mitochondrial inner membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_function	GO:0015075	ion transmembrane transporter activity; IEA:InterPro.
# GO_process	GO:0055072	iron ion homeostasis; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0042592	homeostatic process
# Genevisible	Q6P4A7	HS
# HGNC	HGNC:16088	SFXN4
# IntAct	Q6P4A7	7
# InterPro	IPR004686	Mtc
# InterPro	IPR028825	SFXN4
# MIM	615564	gene
# MIM	615578	phenotype
# Organism	SFXN4_HUMAN	Homo sapiens (Human)
# Orphanet	391348	Growth and developmental delay-hypotonia-vision impairment-lactic acidosis syndrome
# PANTHER	PTHR11153	PTHR11153
# PANTHER	PTHR11153:SF3	PTHR11153:SF3
# Pfam	PF03820	Mtc
# Proteomes	UP000005640	Chromosome 10
# RecName	SFXN4_HUMAN	Sideroflexin-4
# RefSeq	NP_998814	NM_213649.1. [Q6P4A7-1]
# RefSeq	XP_005269583	XM_005269526.2. [Q6P4A7-3]
# RefSeq	XP_005269584	XM_005269527.1. [Q6P4A7-3]
# RefSeq	XP_011537584	XM_011539282.2. [Q6P4A7-3]
# SIMILARITY	Belongs to the sideroflexin family. {ECO	0000305}.
# SUBCELLULAR LOCATION	SFXN4_HUMAN	Mitochondrion inner membrane {ECO 0000269|PubMed 24119684}; Multi-pass membrane protein {ECO 0000269|PubMed 24119684}. 
# TCDB	2.A.54.1	the mitochondrial tricarboxylate carrier (mtc) family
# UCSC	uc001leb	human. [Q6P4A7-1]
# eggNOG	ENOG410YU8V	LUCA
# eggNOG	KOG3767	Eukaryota
BLAST	swissprot:SFXN4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SFXN4_HUMAN
BioCyc	ZFISH:G66-33038-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33038-MONOMER
COXPRESdb	119559	http://coxpresdb.jp/data/gene/119559.shtml
CleanEx	HS_SFXN4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SFXN4
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.ajhg.2013.09.011	http://dx.doi.org/10.1016/j.ajhg.2013.09.011
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1038/nature02462	http://dx.doi.org/10.1038/nature02462
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1080/10425170310001605491	http://dx.doi.org/10.1080/10425170310001605491
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF336980	http://www.ebi.ac.uk/ena/data/view/AF336980
EMBL	AL355598	http://www.ebi.ac.uk/ena/data/view/AL355598
EMBL	AL355598	http://www.ebi.ac.uk/ena/data/view/AL355598
EMBL	AL355861	http://www.ebi.ac.uk/ena/data/view/AL355861
EMBL	AL355861	http://www.ebi.ac.uk/ena/data/view/AL355861
EMBL	AY269785	http://www.ebi.ac.uk/ena/data/view/AY269785
EMBL	BC063562	http://www.ebi.ac.uk/ena/data/view/BC063562
Ensembl	ENST00000355697	http://www.ensembl.org/id/ENST00000355697
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0015075	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015075
GO_process	GO:0055072	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GeneCards	SFXN4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SFXN4
GeneID	119559	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=119559
GeneTree	ENSGT00390000002026	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002026
HGNC	HGNC:16088	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16088
HOGENOM	HOG000010305	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000010305&db=HOGENOM6
HOVERGEN	HBG104924	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG104924&db=HOVERGEN
HPA	HPA018028	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA018028
HPA	HPA020872	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA020872
InParanoid	Q6P4A7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6P4A7
IntAct	Q6P4A7	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q6P4A7*
InterPro	IPR004686	http://www.ebi.ac.uk/interpro/entry/IPR004686
InterPro	IPR028825	http://www.ebi.ac.uk/interpro/entry/IPR028825
Jabion	119559	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=119559
KEGG_Gene	hsa:119559	http://www.genome.jp/dbget-bin/www_bget?hsa:119559
MIM	615564	http://www.ncbi.nlm.nih.gov/omim/615564
MIM	615578	http://www.ncbi.nlm.nih.gov/omim/615578
OMA	RFWITER	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RFWITER
Orphanet	391348	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=391348
OrthoDB	EOG091G0CUA	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0CUA
PANTHER	PTHR11153	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11153
PANTHER	PTHR11153:SF3	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11153:SF3
PSORT	swissprot:SFXN4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SFXN4_HUMAN
PSORT-B	swissprot:SFXN4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SFXN4_HUMAN
PSORT2	swissprot:SFXN4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SFXN4_HUMAN
Pfam	PF03820	http://pfam.xfam.org/family/PF03820
PharmGKB	PA38093	http://www.pharmgkb.org/do/serve?objId=PA38093&objCls=Gene
Phobius	swissprot:SFXN4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SFXN4_HUMAN
PhylomeDB	Q6P4A7	http://phylomedb.org/?seqid=Q6P4A7
ProteinModelPortal	Q6P4A7	http://www.proteinmodelportal.org/query/uniprot/Q6P4A7
PubMed	14756423	http://www.ncbi.nlm.nih.gov/pubmed/14756423
PubMed	15164054	http://www.ncbi.nlm.nih.gov/pubmed/15164054
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	24119684	http://www.ncbi.nlm.nih.gov/pubmed/24119684
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
RefSeq	NP_998814	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_998814
RefSeq	XP_005269583	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005269583
RefSeq	XP_005269584	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005269584
RefSeq	XP_011537584	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011537584
STRING	9606.ENSP00000347924	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000347924&targetmode=cogs
TCDB	2.A.54.1	http://www.tcdb.org/search/result.php?tc=2.A.54.1
UCSC	uc001leb	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001leb&org=rat
UniGene	Hs.655168	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.655168
UniProtKB	SFXN4_HUMAN	http://www.uniprot.org/uniprot/SFXN4_HUMAN
UniProtKB-AC	Q6P4A7	http://www.uniprot.org/uniprot/Q6P4A7
charge	swissprot:SFXN4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SFXN4_HUMAN
eggNOG	ENOG410YU8V	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YU8V
eggNOG	KOG3767	http://eggnogapi.embl.de/nog_data/html/tree/KOG3767
epestfind	swissprot:SFXN4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SFXN4_HUMAN
garnier	swissprot:SFXN4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SFXN4_HUMAN
helixturnhelix	swissprot:SFXN4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SFXN4_HUMAN
hmoment	swissprot:SFXN4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SFXN4_HUMAN
iep	swissprot:SFXN4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SFXN4_HUMAN
inforesidue	swissprot:SFXN4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SFXN4_HUMAN
neXtProt	NX_Q6P4A7	http://www.nextprot.org/db/entry/NX_Q6P4A7
octanol	swissprot:SFXN4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SFXN4_HUMAN
pepcoil	swissprot:SFXN4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SFXN4_HUMAN
pepdigest	swissprot:SFXN4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SFXN4_HUMAN
pepinfo	swissprot:SFXN4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SFXN4_HUMAN
pepnet	swissprot:SFXN4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SFXN4_HUMAN
pepstats	swissprot:SFXN4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SFXN4_HUMAN
pepwheel	swissprot:SFXN4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SFXN4_HUMAN
pepwindow	swissprot:SFXN4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SFXN4_HUMAN
sigcleave	swissprot:SFXN4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SFXN4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S4A8_HUMAN	Event=Alternative splicing; Named isoforms=8; Name=1 {ECO 0000269|Ref.2}; IsoId=Q2Y0W8-1; Sequence=Displayed; Name=2 {ECO 0000269|PubMed 9872452}; IsoId=Q2Y0W8-2; Sequence=VSP_052760, VSP_052765; Note=No experimental confirmation available. {ECO 0000305}; Name=3 {ECO 0000269|PubMed 11133997}; IsoId=Q2Y0W8-3; Sequence=VSP_052765; Note=May be due to an intron retention.; Name=4 {ECO 0000269|Ref.2}; IsoId=Q2Y0W8-4; Sequence=VSP_052759, VSP_052765; Note=May be due to an intron retention.; Name=5 {ECO 0000269|Ref.2}; IsoId=Q2Y0W8-5; Sequence=VSP_052759; Name=6 {ECO 0000269|PubMed 15489334}; IsoId=Q2Y0W8-6; Sequence=VSP_052761, VSP_052762; Name=7; IsoId=Q2Y0W8-7; Sequence=VSP_052759, VSP_052763, VSP_052764; Note=No experimental confirmation available. Ref.5 (CAD38576) sequence is in conflict in position  707 Q->R. Ref.5 (CAD38576) sequence is in conflict in position  716 R->G. {ECO 0000305}; Name=8; IsoId=Q2Y0W8-8; Sequence=VSP_052759, VSP_052761, VSP_052762; Note=No experimental confirmation available.; 
# AltName	S4A8_HUMAN	Electroneutral Na(+)-driven Cl-HCO3 exchanger
# AltName	S4A8_HUMAN	Solute carrier family 4 member 8
# AltName	S4A8_HUMAN	k-NBC3
# BioGrid	114877	30
# CCDS	CCDS44890	-. [Q2Y0W8-1]
# CCDS	CCDS58232	-. [Q2Y0W8-7]
# CCDS	CCDS58233	-. [Q2Y0W8-8]
# CCDS	CCDS73470	-. [Q2Y0W8-5]
# ChiTaRS	SLC4A8	human
# DrugBank	DB01390	Sodium bicarbonate
# ENZYME REGULATION	S4A8_HUMAN	Activity is inhibited by 4,4'-Di- isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters). 
# Ensembl	ENST00000358657	ENSP00000351483; ENSG00000050438. [Q2Y0W8-5]
# Ensembl	ENST00000453097	ENSP00000405812; ENSG00000050438. [Q2Y0W8-1]
# Ensembl	ENST00000514353	ENSP00000442561; ENSG00000050438. [Q2Y0W8-7]
# Ensembl	ENST00000535225	ENSP00000441520; ENSG00000050438. [Q2Y0W8-8]
# FUNCTION	S4A8_HUMAN	Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+) HCO3(-) stoichiometry of 2 1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity. {ECO 0000269|PubMed 10362779, ECO 0000269|PubMed 11133997}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0032809	neuronal cell body membrane; IEA:Ensembl.
# GO_component	GO:0043005	neuron projection; IEA:Ensembl.
# GO_function	GO:0005452	inorganic anion exchanger activity; TAS:Reactome.
# GO_function	GO:0008509	anion transmembrane transporter activity; IBA:GO_Central.
# GO_function	S4A8_HUMAN	GO 0015301 anion anion antiporter activity; IEA UniProtKB-KW.
# GO_process	GO:0006814	sodium ion transport; IEA:UniProtKB-KW.
# GO_process	GO:0015701	bicarbonate transport; IBA:GO_Central.
# GO_process	GO:0051453	regulation of intracellular pH; IBA:GO_Central.
# GO_process	GO:0098656	anion transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.1100.10	-; 1.
# Genevisible	Q2Y0W8	HS
# HGNC	HGNC:11034	SLC4A8
# InterPro	IPR003020	HCO3_transpt_euk
# InterPro	IPR003024	Na/HCO3_transpt
# InterPro	IPR011531	HCO3_transpt_C
# InterPro	IPR013769	Band3_cytoplasmic_dom
# InterPro	IPR016152	PTrfase/Anion_transptr
# KEGG_Brite	ko02001	Solute carrier family
# MIM	605024	gene
# Organism	S4A8_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11453	PTHR11453
# PRINTS	PR01231	HCO3TRNSPORT
# PRINTS	PR01232	NAHCO3TRSPRT
# Pfam	PF00955	HCO3_cotransp
# Pfam	PF07565	Band_3_cyto
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-425381	Bicarbonate transporters
# RecName	S4A8_HUMAN	Electroneutral sodium bicarbonate exchanger 1
# RefSeq	NP_001035049	NM_001039960.2. [Q2Y0W8-1]
# RefSeq	NP_001245330	NM_001258401.2. [Q2Y0W8-5]
# RefSeq	NP_001245331	NM_001258402.1. [Q2Y0W8-6]
# RefSeq	NP_001245332	NM_001258403.1. [Q2Y0W8-7]
# RefSeq	NP_001254544	NM_001267615.1. [Q2Y0W8-8]
# RefSeq	XP_016875730	XM_017020241.1. [Q2Y0W8-2]
# SEQUENCE CAUTION	Sequence=BAA34459.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD38576.2; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the anion exchanger (TC 2.A.31) family. {ECO	0000255}. 
# SUBCELLULAR LOCATION	S4A8_HUMAN	Membrane {ECO 0000269|PubMed 17715183}; Multi-pass membrane protein {ECO 0000269|PubMed 17715183}. 
# SUPFAM	SSF55804	SSF55804
# TCDB	2.A.31.2	the anion exchanger (ae) family
# TIGRFAMs	TIGR00834	ae
# TISSUE SPECIFICITY	S4A8_HUMAN	Expressed in the pyramidal cells of the hippocampus (at protein level). Highly expressed in all major regions of the brain, spinal column and in testis, and moderate levels in trachea, thyroid and medulla region of kidney. Low expression levels observed in pancreas and kidney cortex. {ECO 0000269|PubMed 10362779, ECO 0000269|PubMed 11133997, ECO 0000269|PubMed 17715183}. 
# UCSC	uc001rys	human. [Q2Y0W8-1]
# eggNOG	ENOG410XPHD	LUCA
# eggNOG	KOG1172	Eukaryota
BLAST	swissprot:S4A8_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S4A8_HUMAN
COXPRESdb	9498	http://coxpresdb.jp/data/gene/9498.shtml
CleanEx	HS_SLC4A8	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC4A8
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/jbc.C000716200	http://dx.doi.org/10.1074/jbc.C000716200
DOI	10.1093/dnares/5.5.277	http://dx.doi.org/10.1093/dnares/5.5.277
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1152/ajpregu.00356.2007	http://dx.doi.org/10.1152/ajpregu.00356.2007
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DrugBank	DB01390	http://www.drugbank.ca/drugs/DB01390
EMBL	AB018282	http://www.ebi.ac.uk/ena/data/view/AB018282
EMBL	AC025097	http://www.ebi.ac.uk/ena/data/view/AC025097
EMBL	AC046135	http://www.ebi.ac.uk/ena/data/view/AC046135
EMBL	AC107031	http://www.ebi.ac.uk/ena/data/view/AC107031
EMBL	AF069512	http://www.ebi.ac.uk/ena/data/view/AF069512
EMBL	AF107099	http://www.ebi.ac.uk/ena/data/view/AF107099
EMBL	AK295315	http://www.ebi.ac.uk/ena/data/view/AK295315
EMBL	AL831915	http://www.ebi.ac.uk/ena/data/view/AL831915
EMBL	BC025994	http://www.ebi.ac.uk/ena/data/view/BC025994
EMBL	CH471111	http://www.ebi.ac.uk/ena/data/view/CH471111
EMBL	DQ063579	http://www.ebi.ac.uk/ena/data/view/DQ063579
EMBL	DQ975204	http://www.ebi.ac.uk/ena/data/view/DQ975204
EMBL	DQ996398	http://www.ebi.ac.uk/ena/data/view/DQ996398
EMBL	DQ996537	http://www.ebi.ac.uk/ena/data/view/DQ996537
Ensembl	ENST00000358657	http://www.ensembl.org/id/ENST00000358657
Ensembl	ENST00000453097	http://www.ensembl.org/id/ENST00000453097
Ensembl	ENST00000514353	http://www.ensembl.org/id/ENST00000514353
Ensembl	ENST00000535225	http://www.ensembl.org/id/ENST00000535225
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0032809	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032809
GO_component	GO:0043005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043005
GO_function	GO:0005452	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005452
GO_function	GO:0008509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008509
GO_function	GO:0015301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015301
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0015701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015701
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GO_process	GO:0098656	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098656
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.1100.10	http://www.cathdb.info/version/latest/superfamily/3.40.1100.10
GeneCards	SLC4A8	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC4A8
GeneID	9498	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9498
GeneTree	ENSGT00760000119021	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119021
HGNC	HGNC:11034	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11034
HOGENOM	HOG000280684	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280684&db=HOGENOM6
HOVERGEN	HBG004326	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004326&db=HOVERGEN
InParanoid	Q2Y0W8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q2Y0W8
IntAct	Q2Y0W8	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q2Y0W8*
InterPro	IPR003020	http://www.ebi.ac.uk/interpro/entry/IPR003020
InterPro	IPR003024	http://www.ebi.ac.uk/interpro/entry/IPR003024
InterPro	IPR011531	http://www.ebi.ac.uk/interpro/entry/IPR011531
InterPro	IPR013769	http://www.ebi.ac.uk/interpro/entry/IPR013769
InterPro	IPR016152	http://www.ebi.ac.uk/interpro/entry/IPR016152
Jabion	9498	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9498
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:9498	http://www.genome.jp/dbget-bin/www_bget?hsa:9498
KEGG_Orthology	KO:K13859	http://www.genome.jp/dbget-bin/www_bget?KO:K13859
MIM	605024	http://www.ncbi.nlm.nih.gov/omim/605024
OMA	EMGGDKF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EMGGDKF
OrthoDB	EOG091G01FT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01FT
PANTHER	PTHR11453	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11453
PRINTS	PR01231	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01231
PRINTS	PR01232	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01232
PSORT	swissprot:S4A8_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S4A8_HUMAN
PSORT-B	swissprot:S4A8_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S4A8_HUMAN
PSORT2	swissprot:S4A8_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S4A8_HUMAN
Pfam	PF00955	http://pfam.xfam.org/family/PF00955
Pfam	PF07565	http://pfam.xfam.org/family/PF07565
PharmGKB	PA35900	http://www.pharmgkb.org/do/serve?objId=PA35900&objCls=Gene
Phobius	swissprot:S4A8_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S4A8_HUMAN
PhylomeDB	Q2Y0W8	http://phylomedb.org/?seqid=Q2Y0W8
ProteinModelPortal	Q2Y0W8	http://www.proteinmodelportal.org/query/uniprot/Q2Y0W8
PubMed	10362779	http://www.ncbi.nlm.nih.gov/pubmed/10362779
PubMed	11133997	http://www.ncbi.nlm.nih.gov/pubmed/11133997
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	17715183	http://www.ncbi.nlm.nih.gov/pubmed/17715183
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	9872452	http://www.ncbi.nlm.nih.gov/pubmed/9872452
Reactome	R-HSA-425381	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425381
RefSeq	NP_001035049	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001035049
RefSeq	NP_001245330	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001245330
RefSeq	NP_001245331	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001245331
RefSeq	NP_001245332	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001245332
RefSeq	NP_001254544	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001254544
RefSeq	XP_016875730	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016875730
STRING	9606.ENSP00000405812	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000405812&targetmode=cogs
SUPFAM	SSF55804	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55804
TCDB	2.A.31.2	http://www.tcdb.org/search/result.php?tc=2.A.31.2
TIGRFAMs	TIGR00834	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00834
UCSC	uc001rys	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001rys&org=rat
UniGene	Hs.4749	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.4749
UniProtKB	S4A8_HUMAN	http://www.uniprot.org/uniprot/S4A8_HUMAN
UniProtKB-AC	Q2Y0W8	http://www.uniprot.org/uniprot/Q2Y0W8
charge	swissprot:S4A8_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S4A8_HUMAN
eggNOG	ENOG410XPHD	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPHD
eggNOG	KOG1172	http://eggnogapi.embl.de/nog_data/html/tree/KOG1172
epestfind	swissprot:S4A8_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S4A8_HUMAN
garnier	swissprot:S4A8_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S4A8_HUMAN
helixturnhelix	swissprot:S4A8_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S4A8_HUMAN
hmoment	swissprot:S4A8_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S4A8_HUMAN
iep	swissprot:S4A8_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S4A8_HUMAN
inforesidue	swissprot:S4A8_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S4A8_HUMAN
neXtProt	NX_Q2Y0W8	http://www.nextprot.org/db/entry/NX_Q2Y0W8
octanol	swissprot:S4A8_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S4A8_HUMAN
pepcoil	swissprot:S4A8_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S4A8_HUMAN
pepdigest	swissprot:S4A8_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S4A8_HUMAN
pepinfo	swissprot:S4A8_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S4A8_HUMAN
pepnet	swissprot:S4A8_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S4A8_HUMAN
pepstats	swissprot:S4A8_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S4A8_HUMAN
pepwheel	swissprot:S4A8_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S4A8_HUMAN
pepwindow	swissprot:S4A8_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S4A8_HUMAN
sigcleave	swissprot:S4A8_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S4A8_HUMAN
## Database	ID	URL or Descriptions
# AltName	PIEZ1_HUMAN	Membrane protein induced by beta-amyloid treatment
# AltName	PIEZ1_HUMAN	Protein FAM38A
# BioGrid	115124	11
# ChiTaRS	PIEZO1	human
# DEVELOPMENTAL STAGE	At 17 weeks of gestation, strongly expressed in hepatic erythroblasts. At that stage, also expressed in fetal splenic plasma cells and in lymphatic vessel of fetal peritoneum. In vitro, up-regulated during the erythroid differentiation of CD34+ cells from healthy donors (at protein level). {ECO:0000269|PubMed	23479567}. 
# DISEASE	PIEZ1_HUMAN	Dehydrated hereditary stomatocytosis 1 with or without pseudohyperkalemia and/or perinatal edema (DHS1) [MIM 194380]  An autosomal dominant hemolytic anemia characterized by primary erythrocyte dehydration. DHS erythrocytes exhibit decreased total cation and potassium content that are not accompanied by a proportional net gain of sodium and water. DHS patients typically exhibit mild to moderate compensated hemolytic anemia, with an increased erythrocyte mean corpuscular hemoglobin concentration and a decreased osmotic fragility, both of which reflect cellular dehydration. Patients may also show perinatal edema and pseudohyperkalemia due to loss of potassium from red cells stored at room temperature. A minor proportion of red cells appear as stomatocytes on blood films. Complications such as splenomegaly and cholelithiasis, resulting from increased red cell trapping in the spleen and elevated bilirubin levels, respectively, may occur. The course of DHS is frequently associated with iron overload, which may lead to hepatosiderosis. {ECO 0000269|PubMed 22529292, ECO 0000269|PubMed 23479567, ECO 0000269|PubMed 23487776, ECO 0000269|PubMed 23581886, ECO 0000269|PubMed 23695678, ECO 0000269|PubMed 23973043}. Note=The disease is caused by mutations affecting the gene represented in this entry. All disease-causing mutations characterized so far produce a gain-of- function phenotype, mutated channels exhibiting increased cation transport in erythroid cells, that could be due to slower channel inactivation rate compared to the wild-type protein. 
# DISEASE	PIEZ1_HUMAN	Lymphedema, hereditary, 3 (LMPH3) [MIM 616843]  A severe form of lymphedema, a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections, and physical impairment. LMPH3 manifests as generalized lymphatic dysplasia, characterized by uniform, widespread lymphedema affecting all segments of the body, with systemic involvement such as intestinal and/or pulmonary lymphangiectasia, pleural effusions, chylothoraces and/or pericardial effusions, and with a high incidence of non-immune hydrops fetalis. {ECO 0000269|PubMed 26333996}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000301015	ENSP00000301015; ENSG00000103335
# ExpressionAtlas	Q92508	baseline and differential
# FUNCTION	PIEZ1_HUMAN	Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed 23479567, PubMed 23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed 20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed 25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity). {ECO 0000250|UniProtKB E2JF22, ECO 0000269|PubMed 20016066, ECO 0000269|PubMed 23479567, ECO 0000269|PubMed 23695678, ECO 0000269|PubMed 25119035}. 
# GO_component	GO:0005783	endoplasmic reticulum; IDA:UniProtKB.
# GO_component	GO:0005789	endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; ISS:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0031258	lamellipodium membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0005261	cation channel activity; ISS:UniProtKB.
# GO_function	GO:0008381	mechanically-gated ion channel activity; IEA:InterPro.
# GO_process	GO:0006812	cation transport; ISS:UniProtKB.
# GO_process	GO:0033625	positive regulation of integrin activation; IMP:UniProtKB.
# GO_process	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q92508	HS
# HGNC	HGNC:28993	PIEZO1
# IntAct	Q92508	10
# InterPro	IPR027272	Piezo
# InterPro	IPR031334	Piezo_RRas-bd_dom
# InterPro	IPR031805	Piezo_dom
# MIM	194380	phenotype
# MIM	611184	gene
# MIM	616843	phenotype
# MISCELLANEOUS	PIEZ1_HUMAN	Piezo comes from the Greek 'piesi' meaning pressure. 
# Organism	PIEZ1_HUMAN	Homo sapiens (Human)
# Orphanet	3202	Dehydrated hereditary stomatocytosis
# PANTHER	PTHR13167	PTHR13167; 2
# Pfam	PF12166	Piezo_RRas_bdg
# Pfam	PF15917	PIEZO
# Proteomes	UP000005640	Chromosome 16
# RecName	PIEZ1_HUMAN	Piezo-type mechanosensitive ion channel component 1
# RefSeq	NP_001136336	NM_001142864.3
# SIMILARITY	Belongs to the PIEZO (TC 1.A.75) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	PIEZ1_HUMAN	Endoplasmic reticulum membrane {ECO 0000269|PubMed 20016066}; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO 0000250|UniProtKB Q0KL00}. Cell membrane {ECO 0000269|PubMed 22529292, ECO 0000269|PubMed 23479567}; Multi- pass membrane protein {ECO 0000305}. Cell projection, lamellipodium membrane {ECO 0000269|PubMed 25119035}. Note=In erythrocytes, located in the plasma membrane (PubMed 22529292, PubMed 23479567). Accumulates at the leading apical lamellipodia of endothelial cells in response to shear stress (PubMed 25119035). {ECO 0000269|PubMed 22529292, ECO 0000269|PubMed 23479567, ECO 0000269|PubMed 25119035}. 
# SUBUNIT	Homotrimer. Interacts with PKD2. Interacts with STOML3. {ECO:0000250|UniProtKB	E2JF22}. 
# TCDB	1.A.75.1	the mechanical nociceptor, piezo (piezo) family
# TISSUE SPECIFICITY	PIEZ1_HUMAN	Expressed in numerous tissues. In normal brain, expressed exclusively in neurons, not in astrocytes. In Alzheimer disease brains, expressed in about half of the activated astrocytes located around classical senile plaques. In Parkinson disease substantia nigra, not detected in melanin-containing neurons nor in activated astrocytes. Expressed in erythrocytes (at protein level). {ECO 0000269|PubMed 16854388, ECO 0000269|PubMed 22529292, ECO 0000269|PubMed 23479567}. 
# UCSC	uc010vpb	human
# eggNOG	ENOG410YVF6	LUCA
# eggNOG	KOG1893	Eukaryota
BLAST	swissprot:PIEZ1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:PIEZ1_HUMAN
BioCyc	ZFISH:ENSG00000103335-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000103335-MONOMER
COXPRESdb	9780	http://coxpresdb.jp/data/gene/9780.shtml
CleanEx	HS_FAM38A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_FAM38A
DOI	10.1016/j.bcmd.2013.07.015	http://dx.doi.org/10.1016/j.bcmd.2013.07.015
DOI	10.1016/j.brainres.2006.06.050	http://dx.doi.org/10.1016/j.brainres.2006.06.050
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature03187	http://dx.doi.org/10.1038/nature03187
DOI	10.1038/nature13701	http://dx.doi.org/10.1038/nature13701
DOI	10.1038/nbt.1532	http://dx.doi.org/10.1038/nbt.1532
DOI	10.1038/ncomms2899	http://dx.doi.org/10.1038/ncomms2899
DOI	10.1038/ncomms9085	http://dx.doi.org/10.1038/ncomms9085
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.1219777110	http://dx.doi.org/10.1073/pnas.1219777110
DOI	10.1093/dnares/3.5.321	http://dx.doi.org/10.1093/dnares/3.5.321
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/cge.12147	http://dx.doi.org/10.1111/cge.12147
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1182/blood-2012-04-422253	http://dx.doi.org/10.1182/blood-2012-04-422253
DOI	10.1182/blood-2013-02-482489	http://dx.doi.org/10.1182/blood-2013-02-482489
DOI	10.1242/jcs.056424	http://dx.doi.org/10.1242/jcs.056424
EMBL	AB161230	http://www.ebi.ac.uk/ena/data/view/AB161230
EMBL	AC138028	http://www.ebi.ac.uk/ena/data/view/AC138028
EMBL	BC150271	http://www.ebi.ac.uk/ena/data/view/BC150271
EMBL	D87071	http://www.ebi.ac.uk/ena/data/view/D87071
Ensembl	ENST00000301015	http://www.ensembl.org/id/ENST00000301015
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0031258	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031258
GO_component	GO:0033116	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033116
GO_function	GO:0005261	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005261
GO_function	GO:0008381	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008381
GO_process	GO:0006812	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006812
GO_process	GO:0033625	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033625
GO_process	GO:0033634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033634
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	PIEZO1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=PIEZO1
GeneID	9780	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9780
GeneTree	ENSGT00390000013029	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000013029
H-InvDB	HIX0022749	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0022749
H-InvDB	HIX0173225	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0173225
HGNC	HGNC:28993	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:28993
HOVERGEN	HBG107901	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG107901&db=HOVERGEN
HPA	HPA047185	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA047185
InParanoid	Q92508	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q92508
IntAct	Q92508	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q92508*
InterPro	IPR027272	http://www.ebi.ac.uk/interpro/entry/IPR027272
InterPro	IPR031334	http://www.ebi.ac.uk/interpro/entry/IPR031334
InterPro	IPR031805	http://www.ebi.ac.uk/interpro/entry/IPR031805
Jabion	9780	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9780
KEGG_Gene	hsa:9780	http://www.genome.jp/dbget-bin/www_bget?hsa:9780
MIM	194380	http://www.ncbi.nlm.nih.gov/omim/194380
MIM	611184	http://www.ncbi.nlm.nih.gov/omim/611184
MIM	616843	http://www.ncbi.nlm.nih.gov/omim/616843
MINT	MINT-4991257	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4991257
OMA	WDSICFF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WDSICFF
Orphanet	3202	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=3202
OrthoDB	EOG091G0SD8	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0SD8
PANTHER	PTHR13167	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13167
PSORT	swissprot:PIEZ1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:PIEZ1_HUMAN
PSORT-B	swissprot:PIEZ1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:PIEZ1_HUMAN
PSORT2	swissprot:PIEZ1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:PIEZ1_HUMAN
Pfam	PF12166	http://pfam.xfam.org/family/PF12166
Pfam	PF15917	http://pfam.xfam.org/family/PF15917
Phobius	swissprot:PIEZ1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:PIEZ1_HUMAN
PhylomeDB	Q92508	http://phylomedb.org/?seqid=Q92508
ProteinModelPortal	Q92508	http://www.proteinmodelportal.org/query/uniprot/Q92508
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15616553	http://www.ncbi.nlm.nih.gov/pubmed/15616553
PubMed	16854388	http://www.ncbi.nlm.nih.gov/pubmed/16854388
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19349973	http://www.ncbi.nlm.nih.gov/pubmed/19349973
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20016066	http://www.ncbi.nlm.nih.gov/pubmed/20016066
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	22529292	http://www.ncbi.nlm.nih.gov/pubmed/22529292
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	23479567	http://www.ncbi.nlm.nih.gov/pubmed/23479567
PubMed	23487776	http://www.ncbi.nlm.nih.gov/pubmed/23487776
PubMed	23581886	http://www.ncbi.nlm.nih.gov/pubmed/23581886
PubMed	23695678	http://www.ncbi.nlm.nih.gov/pubmed/23695678
PubMed	23973043	http://www.ncbi.nlm.nih.gov/pubmed/23973043
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25119035	http://www.ncbi.nlm.nih.gov/pubmed/25119035
PubMed	26333996	http://www.ncbi.nlm.nih.gov/pubmed/26333996
PubMed	9039502	http://www.ncbi.nlm.nih.gov/pubmed/9039502
RefSeq	NP_001136336	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001136336
STRING	9606.ENSP00000301015	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000301015&targetmode=cogs
TCDB	1.A.75.1	http://www.tcdb.org/search/result.php?tc=1.A.75.1
UCSC	uc010vpb	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010vpb&org=rat
UniGene	Hs.377001	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.377001
UniGene	Hs.592074	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.592074
UniProtKB	PIEZ1_HUMAN	http://www.uniprot.org/uniprot/PIEZ1_HUMAN
UniProtKB-AC	Q92508	http://www.uniprot.org/uniprot/Q92508
charge	swissprot:PIEZ1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:PIEZ1_HUMAN
eggNOG	ENOG410YVF6	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YVF6
eggNOG	KOG1893	http://eggnogapi.embl.de/nog_data/html/tree/KOG1893
epestfind	swissprot:PIEZ1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:PIEZ1_HUMAN
garnier	swissprot:PIEZ1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:PIEZ1_HUMAN
helixturnhelix	swissprot:PIEZ1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:PIEZ1_HUMAN
hmoment	swissprot:PIEZ1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:PIEZ1_HUMAN
iep	swissprot:PIEZ1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:PIEZ1_HUMAN
inforesidue	swissprot:PIEZ1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:PIEZ1_HUMAN
neXtProt	NX_Q92508	http://www.nextprot.org/db/entry/NX_Q92508
octanol	swissprot:PIEZ1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:PIEZ1_HUMAN
pepcoil	swissprot:PIEZ1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:PIEZ1_HUMAN
pepdigest	swissprot:PIEZ1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:PIEZ1_HUMAN
pepinfo	swissprot:PIEZ1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:PIEZ1_HUMAN
pepnet	swissprot:PIEZ1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:PIEZ1_HUMAN
pepstats	swissprot:PIEZ1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:PIEZ1_HUMAN
pepwheel	swissprot:PIEZ1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:PIEZ1_HUMAN
pepwindow	swissprot:PIEZ1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:PIEZ1_HUMAN
sigcleave	swissprot:PIEZ1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:PIEZ1_HUMAN
## Database	ID	URL or Descriptions
# AltName	CX7A1_HUMAN	Cytochrome c oxidase subunit VIIa-heart
# AltName	CX7A1_HUMAN	Cytochrome c oxidase subunit VIIa-muscle
# CDD	cd00928	Cyt_c_Oxidase_VIIa
# ChiTaRS	COX7A1	human
# DrugBank	DB02659	Cholic Acid
# Ensembl	ENST00000292907	ENSP00000292907; ENSG00000161281
# ExpressionAtlas	P24310	baseline and differential
# FUNCTION	CX7A1_HUMAN	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. 
# GO_component	GO:0005739	mitochondrion; TAS:ProtInc.
# GO_component	GO:0005746	mitochondrial respiratory chain; IEA:InterPro.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0004129	cytochrome-c oxidase activity; TAS:ProtInc.
# GO_process	GO:0006091	generation of precursor metabolites and energy; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# Gene3D	4.10.91.10	-; 1.
# Genevisible	P24310	HS
# HGNC	HGNC:2287	COX7A1
# InterPro	IPR003177	Cyt_c_oxidase_su7a
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	123995	gene
# Organism	CX7A1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10510	PTHR10510
# PIR	JC1303	OSHU7A
# Proteomes	UP000005640	Chromosome 19
# RecName	CX7A1_HUMAN	Cytochrome c oxidase subunit 7A1, mitochondrial
# RefSeq	NP_001855	NM_001864.3
# SIMILARITY	Belongs to the cytochrome c oxidase VIIa family. {ECO	0000305}.
# SUBCELLULAR LOCATION	CX7A1_HUMAN	Mitochondrion inner membrane. 
# SUPFAM	SSF81419	SSF81419
# TCDB	3.D.4.11	the proton-translocating cytochrome oxidase (cox) superfamily
# eggNOG	ENOG410JE1I	Eukaryota
# eggNOG	ENOG410ZCEG	LUCA
BLAST	swissprot:CX7A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CX7A1_HUMAN
BioCyc	ZFISH:HS14858-MONOMER	http://biocyc.org/getid?id=ZFISH:HS14858-MONOMER
COXPRESdb	1346	http://coxpresdb.jp/data/gene/1346.shtml
CleanEx	HS_COX7A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_COX7A1
DOI	10.1006/geno.1997.4937	http://dx.doi.org/10.1006/geno.1997.4937
DOI	10.1016/0378-1119(92)90287-Y	http://dx.doi.org/10.1016/0378-1119(92)90287-Y
DOI	10.1016/S0167-4781(02)00228-2	http://dx.doi.org/10.1016/S0167-4781(02)00228-2
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DOI	10.1093/oxfordjournals.molbev.a026144	http://dx.doi.org/10.1093/oxfordjournals.molbev.a026144
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1432-1033.1992.tb19847.x	http://dx.doi.org/10.1111/j.1432-1033.1992.tb19847.x
DrugBank	DB02659	http://www.drugbank.ca/drugs/DB02659
EMBL	AC002984	http://www.ebi.ac.uk/ena/data/view/AC002984
EMBL	AD001527	http://www.ebi.ac.uk/ena/data/view/AD001527
EMBL	AF037372	http://www.ebi.ac.uk/ena/data/view/AF037372
EMBL	AF127789	http://www.ebi.ac.uk/ena/data/view/AF127789
EMBL	BC002757	http://www.ebi.ac.uk/ena/data/view/BC002757
EMBL	M83186	http://www.ebi.ac.uk/ena/data/view/M83186
EMBL	U81524	http://www.ebi.ac.uk/ena/data/view/U81524
Ensembl	ENST00000292907	http://www.ensembl.org/id/ENST00000292907
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005746	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005746
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0004129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004129
GO_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
Gene3D	4.10.91.10	http://www.cathdb.info/version/latest/superfamily/4.10.91.10
GeneCards	COX7A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=COX7A1
GeneID	1346	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1346
GeneTree	ENSGT00400000022054	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00400000022054
HGNC	HGNC:2287	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2287
HOGENOM	HOG000264231	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264231&db=HOGENOM6
HOVERGEN	HBG051095	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051095&db=HOVERGEN
InParanoid	P24310	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24310
InterPro	IPR003177	http://www.ebi.ac.uk/interpro/entry/IPR003177
Jabion	1346	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1346
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Gene	hsa:1346	http://www.genome.jp/dbget-bin/www_bget?hsa:1346
KEGG_Orthology	KO:K02270	http://www.genome.jp/dbget-bin/www_bget?KO:K02270
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	123995	http://www.ncbi.nlm.nih.gov/omim/123995
OMA	GWASFPH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GWASFPH
OrthoDB	EOG091G12UD	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G12UD
PANTHER	PTHR10510	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10510
PSORT	swissprot:CX7A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CX7A1_HUMAN
PSORT-B	swissprot:CX7A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CX7A1_HUMAN
PSORT2	swissprot:CX7A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CX7A1_HUMAN
PharmGKB	PA26805	http://www.pharmgkb.org/do/serve?objId=PA26805&objCls=Gene
Phobius	swissprot:CX7A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CX7A1_HUMAN
PhylomeDB	P24310	http://phylomedb.org/?seqid=P24310
ProteinModelPortal	P24310	http://www.proteinmodelportal.org/query/uniprot/P24310
PubMed	10335655	http://www.ncbi.nlm.nih.gov/pubmed/10335655
PubMed	11997101	http://www.ncbi.nlm.nih.gov/pubmed/11997101
PubMed	1309697	http://www.ncbi.nlm.nih.gov/pubmed/1309697
PubMed	1327965	http://www.ncbi.nlm.nih.gov/pubmed/1327965
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	9344674	http://www.ncbi.nlm.nih.gov/pubmed/9344674
RefSeq	NP_001855	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001855
SMR	P24310	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24310
STRING	9606.ENSP00000292907	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000292907&targetmode=cogs
SUPFAM	SSF81419	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81419
TCDB	3.D.4.11	http://www.tcdb.org/search/result.php?tc=3.D.4.11
UniGene	Hs.421621	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.421621
UniProtKB	CX7A1_HUMAN	http://www.uniprot.org/uniprot/CX7A1_HUMAN
UniProtKB-AC	P24310	http://www.uniprot.org/uniprot/P24310
charge	swissprot:CX7A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CX7A1_HUMAN
eggNOG	ENOG410JE1I	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410JE1I
eggNOG	ENOG410ZCEG	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZCEG
epestfind	swissprot:CX7A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CX7A1_HUMAN
garnier	swissprot:CX7A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CX7A1_HUMAN
helixturnhelix	swissprot:CX7A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CX7A1_HUMAN
hmoment	swissprot:CX7A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CX7A1_HUMAN
iep	swissprot:CX7A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CX7A1_HUMAN
inforesidue	swissprot:CX7A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CX7A1_HUMAN
neXtProt	NX_P24310	http://www.nextprot.org/db/entry/NX_P24310
octanol	swissprot:CX7A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CX7A1_HUMAN
pepcoil	swissprot:CX7A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CX7A1_HUMAN
pepdigest	swissprot:CX7A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CX7A1_HUMAN
pepinfo	swissprot:CX7A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CX7A1_HUMAN
pepnet	swissprot:CX7A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CX7A1_HUMAN
pepstats	swissprot:CX7A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CX7A1_HUMAN
pepwheel	swissprot:CX7A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CX7A1_HUMAN
pepwindow	swissprot:CX7A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CX7A1_HUMAN
sigcleave	swissprot:CX7A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CX7A1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ASIC1_HUMAN	Event=Alternative splicing; Named isoforms=3; Comment=The splice variant from ASIC1a described in mouse and rat, which gives rise to an isoform with different N-termini (Asic1b), does not seem to exist in human.; Name=2; Synonyms=Asic1a; IsoId=P78348-2; Sequence=Displayed; Name=1; IsoId=P78348-1; Sequence=VSP_015596; Name=3; IsoId=P78348-3; Sequence=VSP_045298; 
# AltName	ASIC1_HUMAN	Amiloride-sensitive cation channel 2, neuronal
# AltName	ASIC1_HUMAN	Brain sodium channel 2
# BioGrid	106559	12
# CCDS	CCDS44876	-. [P78348-2]
# CCDS	CCDS58228	-. [P78348-3]
# CCDS	CCDS8796	-. [P78348-1]
# DOMAIN	ASIC1_HUMAN	Channel opening involves a conformation change that affects primarily the extracellular domain and the second transmembrane helix and its orientation in the membrane. In the open state, the second transmembrane helix is nearly perpendicular to the plane of the membrane; in the desensitized state it is strongly tilted. Besides, the second transmembrane domain is discontinuously helical in the open state. The GAS motif of the selectivity filter is in an extended conformation, giving rise to a distinct kink in the polypeptide chain. A domain swap between subunits gives rise to a full-length transmembrane helix (By similarity). {ECO 0000250}. 
# DrugBank	DB00586	Diclofenac
# DrugBank	DB00594	Amiloride
# ENZYME REGULATION	Inhibited by the diuretic amiloride. Inhibited by Cs(1+) ions. Inhibited by spider venom psalmotoxin 1; this locks the channel into its desensitized conformation. {ECO:0000269|PubMed	22760635}. 
# Ensembl	ENST00000228468	ENSP00000228468; ENSG00000110881. [P78348-1]
# Ensembl	ENST00000447966	ENSP00000400228; ENSG00000110881. [P78348-2]
# Ensembl	ENST00000552438	ENSP00000450247; ENSG00000110881. [P78348-3]
# ExpressionAtlas	P78348	baseline and differential
# FUNCTION	ASIC1_HUMAN	Isoform 1 does not display proton-gated cation channel activity. {ECO 0000269|PubMed 22760635}. 
# FUNCTION	ASIC1_HUMAN	Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear. {ECO 0000269|PubMed 22760635}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IMP:UniProtKB.
# GO_component	GO:0009986	cell surface; IEA:Ensembl.
# GO_component	GO:0045202	synapse; IEA:Ensembl.
# GO_function	GO:0015280	ligand-gated sodium channel activity; TAS:ProtInc.
# GO_function	GO:0022839	ion gated channel activity; IEA:Ensembl.
# GO_function	GO:0044736	acid-sensing ion channel activity; IDA:UniProtKB.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006814	sodium ion transport; NAS:UniProtKB.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0007613	memory; IEA:Ensembl.
# GO_process	GO:0008306	associative learning; IEA:Ensembl.
# GO_process	GO:0009268	response to pH; TAS:ProtInc.
# GO_process	GO:0010447	response to acidic pH; IEA:Ensembl.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0035725	sodium ion transmembrane transport; IDA:UniProtKB.
# GO_process	GO:0042391	regulation of membrane potential; IEA:Ensembl.
# GO_process	GO:0046929	negative regulation of neurotransmitter secretion; IEA:Ensembl.
# GO_process	GO:0050915	sensory perception of sour taste; IMP:UniProtKB.
# GO_process	GO:0070207	protein homotrimerization; ISS:UniProtKB.
# GO_process	GO:0070588	calcium ion transmembrane transport; IEA:Ensembl.
# GO_process	GO:0071467	cellular response to pH; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P78348	HS
# HGNC	HGNC:100	ASIC1
# INTERACTION	ASIC1_HUMAN	Q9NRD5 PICK1; NbExp=3; IntAct=EBI-79189, EBI-79165; 
# IntAct	P78348	2
# InterPro	IPR001873	Na+channel_ASC
# InterPro	IPR004724	ENaC
# InterPro	IPR020903	Na+channel_ASC_CS
# KEGG_Brite	ko04040	Ion channels
# MIM	602866	gene
# MISCELLANEOUS	Potentiated by Ca(2+), Mg(2+), Ba(2+) and multivalent cations. Inhibited by anti-inflammatory drugs like salicylic acid (By similarity). Potentiated by FMRFamide-related neuropeptides. PH dependence may be regulated by serine proteases. {ECO	0000250}. 
# Organism	ASIC1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11690	PTHR11690
# PRINTS	PR01078	AMINACHANNEL
# PROSITE	PS01206	ASC
# PTM	ASIC1_HUMAN	Phosphorylation by PKA regulates interaction with PRKCABP and subcellular location. Phosphorylation by PKC may regulate the channel. {ECO 0000269|PubMed 12244121, ECO 0000269|PubMed 12578970}. 
# Pfam	PF00858	ASC
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	ASIC1_HUMAN	Acid-sensing ion channel 1
# RefSeq	NP_001086	NM_001095.3. [P78348-2]
# RefSeq	NP_001243759	NM_001256830.1. [P78348-3]
# RefSeq	NP_064423	NM_020039.3. [P78348-1]
# SIMILARITY	Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC1 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	ASIC1_HUMAN	Cell membrane {ECO 0000269|PubMed 12578970, ECO 0000269|PubMed 21036899, ECO 0000269|PubMed 22760635}; Multi- pass membrane protein {ECO 0000269|PubMed 12578970, ECO 0000269|PubMed 21036899, ECO 0000269|PubMed 22760635}. Note=Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4 (By similarity). {ECO 0000250}. 
# SUBUNIT	ASIC1_HUMAN	Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with STOM and ASIC2 (By similarity). Interacts with PRKCABP. Interacts with spider venom psalmotoxin 1. {ECO 0000250, ECO 0000269|PubMed 11802773, ECO 0000269|PubMed 12578970, ECO 0000269|PubMed 22760635}. 
# TIGRFAMs	TIGR00859	ENaC
# TISSUE SPECIFICITY	ASIC1_HUMAN	Expressed in most or all neurons. 
# UCSC	uc001rvv	human. [P78348-2]
BLAST	swissprot:ASIC1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ASIC1_HUMAN
BioCyc	ZFISH:ENSG00000110881-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000110881-MONOMER
COXPRESdb	41	http://coxpresdb.jp/data/gene/41.shtml
CleanEx	HS_ACCN2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ACCN2
DOI	10.1016/S0896-6273(00)81144-7	http://dx.doi.org/10.1016/S0896-6273(00)81144-7
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1038/ncomms1917	http://dx.doi.org/10.1038/ncomms1917
DOI	10.1042/0264-6021:3610443	http://dx.doi.org/10.1042/0264-6021:3610443
DOI	10.1073/pnas.252782799	http://dx.doi.org/10.1073/pnas.252782799
DOI	10.1073/pnas.94.4.1459	http://dx.doi.org/10.1073/pnas.94.4.1459
DOI	10.1074/jbc.M110.171330	http://dx.doi.org/10.1074/jbc.M110.171330
DOI	10.1074/jbc.M208995200	http://dx.doi.org/10.1074/jbc.M208995200
DOI	10.1074/jbc.M407381200	http://dx.doi.org/10.1074/jbc.M407381200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00586	http://www.drugbank.ca/drugs/DB00586
DrugBank	DB00594	http://www.drugbank.ca/drugs/DB00594
EMBL	AC025154	http://www.ebi.ac.uk/ena/data/view/AC025154
EMBL	BC013891	http://www.ebi.ac.uk/ena/data/view/BC013891
EMBL	BC133707	http://www.ebi.ac.uk/ena/data/view/BC133707
EMBL	CH471111	http://www.ebi.ac.uk/ena/data/view/CH471111
EMBL	EU078959	http://www.ebi.ac.uk/ena/data/view/EU078959
EMBL	HM991481	http://www.ebi.ac.uk/ena/data/view/HM991481
EMBL	U78180	http://www.ebi.ac.uk/ena/data/view/U78180
EMBL	U78181	http://www.ebi.ac.uk/ena/data/view/U78181
Ensembl	ENST00000228468	http://www.ensembl.org/id/ENST00000228468
Ensembl	ENST00000447966	http://www.ensembl.org/id/ENST00000447966
Ensembl	ENST00000552438	http://www.ensembl.org/id/ENST00000552438
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0045202	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045202
GO_function	GO:0015280	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015280
GO_function	GO:0022839	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022839
GO_function	GO:0044736	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044736
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007613	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007613
GO_process	GO:0008306	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008306
GO_process	GO:0009268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009268
GO_process	GO:0010447	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010447
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0035725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035725
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0046929	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046929
GO_process	GO:0050915	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050915
GO_process	GO:0070207	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070207
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:0071467	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071467
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ASIC1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ASIC1
GeneID	41	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=41
GeneTree	ENSGT00760000119120	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119120
HGNC	HGNC:100	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:100
HOGENOM	HOG000247010	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000247010&db=HOGENOM6
HOVERGEN	HBG004150	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004150&db=HOVERGEN
HPA	HPA065870	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA065870
InParanoid	P78348	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P78348
IntAct	P78348	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P78348*
InterPro	IPR001873	http://www.ebi.ac.uk/interpro/entry/IPR001873
InterPro	IPR004724	http://www.ebi.ac.uk/interpro/entry/IPR004724
InterPro	IPR020903	http://www.ebi.ac.uk/interpro/entry/IPR020903
Jabion	41	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=41
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:41	http://www.genome.jp/dbget-bin/www_bget?hsa:41
KEGG_Orthology	KO:K04829	http://www.genome.jp/dbget-bin/www_bget?KO:K04829
MIM	602866	http://www.ncbi.nlm.nih.gov/omim/602866
OMA	PLGDIWG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PLGDIWG
OrthoDB	EOG091G053J	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G053J
PANTHER	PTHR11690	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11690
PRINTS	PR01078	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01078
PROSITE	PS01206	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01206
PSORT	swissprot:ASIC1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ASIC1_HUMAN
PSORT-B	swissprot:ASIC1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ASIC1_HUMAN
PSORT2	swissprot:ASIC1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ASIC1_HUMAN
Pfam	PF00858	http://pfam.xfam.org/family/PF00858
PharmGKB	PA24434	http://www.pharmgkb.org/do/serve?objId=PA24434&objCls=Gene
Phobius	swissprot:ASIC1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ASIC1_HUMAN
PhylomeDB	P78348	http://phylomedb.org/?seqid=P78348
ProteinModelPortal	P78348	http://www.proteinmodelportal.org/query/uniprot/P78348
PubMed	10798398	http://www.ncbi.nlm.nih.gov/pubmed/10798398
PubMed	11802773	http://www.ncbi.nlm.nih.gov/pubmed/11802773
PubMed	12244121	http://www.ncbi.nlm.nih.gov/pubmed/12244121
PubMed	12578970	http://www.ncbi.nlm.nih.gov/pubmed/12578970
PubMed	15247234	http://www.ncbi.nlm.nih.gov/pubmed/15247234
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	21036899	http://www.ncbi.nlm.nih.gov/pubmed/21036899
PubMed	22760635	http://www.ncbi.nlm.nih.gov/pubmed/22760635
PubMed	9037075	http://www.ncbi.nlm.nih.gov/pubmed/9037075
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_001086	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001086
RefSeq	NP_001243759	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243759
RefSeq	NP_064423	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_064423
SMR	P78348	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P78348
TIGRFAMs	TIGR00859	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00859
UCSC	uc001rvv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001rvv&org=rat
UniGene	Hs.274361	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.274361
UniProtKB	ASIC1_HUMAN	http://www.uniprot.org/uniprot/ASIC1_HUMAN
UniProtKB-AC	P78348	http://www.uniprot.org/uniprot/P78348
charge	swissprot:ASIC1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ASIC1_HUMAN
epestfind	swissprot:ASIC1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ASIC1_HUMAN
garnier	swissprot:ASIC1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ASIC1_HUMAN
helixturnhelix	swissprot:ASIC1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ASIC1_HUMAN
hmoment	swissprot:ASIC1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ASIC1_HUMAN
iep	swissprot:ASIC1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ASIC1_HUMAN
inforesidue	swissprot:ASIC1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ASIC1_HUMAN
neXtProt	NX_P78348	http://www.nextprot.org/db/entry/NX_P78348
octanol	swissprot:ASIC1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ASIC1_HUMAN
pepcoil	swissprot:ASIC1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ASIC1_HUMAN
pepdigest	swissprot:ASIC1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ASIC1_HUMAN
pepinfo	swissprot:ASIC1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ASIC1_HUMAN
pepnet	swissprot:ASIC1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ASIC1_HUMAN
pepstats	swissprot:ASIC1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ASIC1_HUMAN
pepwheel	swissprot:ASIC1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ASIC1_HUMAN
pepwindow	swissprot:ASIC1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ASIC1_HUMAN
sigcleave	swissprot:ASIC1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ASIC1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	G6PT1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O43826-1; Sequence=Displayed; Name=2; IsoId=O43826-2; Sequence=VSP_006171; 
# AltName	G6PT1_HUMAN	Glucose-5-phosphate transporter
# AltName	Glucose-6-phosphate translocase {ECO:0000303|PubMed	9428641}
# AltName	Solute carrier family 37 member 4 {ECO:0000312|HGNC	HGNC:4061}
# AltName	Transformation-related gene 19 protein {ECO:0000312|EMBL	AAS00495.1}
# BioGrid	108817	2
# CDD	cd06174	MFS
# DISEASE	G6PT1_HUMAN	Glycogen storage disease 1B (GSD1B) [MIM 232220]  A metabolic disorder characterized by impairment of terminal steps of glycogenolysis and gluconeogenesis. Patients manifest a wide range of clinical symptoms and biochemical abnormalities, including hypoglycemia, severe hepatomegaly due to excessive accumulation of glycogen, kidney enlargement, growth retardation, lactic acidemia, hyperlipidemia, and hyperuricemia. Glycogen storage disease type 1B patients also present a tendency towards infections associated with neutropenia, relapsing aphthous gingivostomatitis, and inflammatory bowel disease. {ECO 0000269|PubMed 10026167, ECO 0000269|PubMed 10482875, ECO 0000269|PubMed 10482962, ECO 0000269|PubMed 10518030, ECO 0000269|PubMed 10874322, ECO 0000269|PubMed 10923042, ECO 0000269|PubMed 10931421, ECO 0000269|PubMed 11071391, ECO 0000269|PubMed 11949931, ECO 0000269|PubMed 12409273, ECO 0000269|PubMed 15059622, ECO 0000269|PubMed 15669677, ECO 0000269|PubMed 15953877, ECO 0000269|PubMed 19579760, ECO 0000269|PubMed 21629566, ECO 0000269|PubMed 9428641, ECO 0000269|PubMed 9675154, ECO 0000269|PubMed 9758626, ECO 0000269|PubMed 9781688, ECO 0000269|PubMed 9856496, ECO 0000269|Ref.20}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	G6PT1_HUMAN	Glycogen storage disease 1C (GSD1C) [MIM 232240]  A metabolic disorder characterized by impairment of terminal steps of glycogenolysis and gluconeogenesis. Patients manifest a wide range of clinical symptoms and biochemical abnormalities, including hypoglycemia, severe hepatomegaly due to excessive accumulation of glycogen, kidney enlargement, growth retardation, lactic acidemia, hyperlipidemia, and hyperuricemia. {ECO 0000269|PubMed 10482962, ECO 0000269|PubMed 9758626}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	G6PT1_HUMAN	Glycogen storage disease 1D (GSD1D) [MIM 232240]  A metabolic disorder characterized by impairment of terminal steps of glycogenolysis and gluconeogenesis. Patients manifest a wide range of clinical symptoms and biochemical abnormalities, including hypoglycemia, severe hepatomegaly due to excessive accumulation of glycogen, kidney enlargement, growth retardation, lactic acidemia, hyperlipidemia, and hyperuricemia. {ECO 0000269|PubMed 9758626}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# ENZYME REGULATION	Inhibited by vanadate and chlorogenic acid. {ECO:0000269|PubMed	21949678}. 
# Ensembl	ENST00000631372	ENSP00000486168; ENSG00000281500. [O43826-1]
# FUNCTION	G6PT1_HUMAN	Inorganic phosphate and glucose-6-phosphate antiporter of the endoplasmic reticulum. Transports cytoplasmic glucose-6- phosphate into the lumen of the endoplasmic reticulum and translocates inorganic phosphate into the opposite direction. Forms with glucose-6-phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels. {ECO 0000269|PubMed 10026167, ECO 0000269|PubMed 21949678}. 
# GO_component	GO:0005783	endoplasmic reticulum; NAS:UniProtKB.
# GO_component	GO:0005789	endoplasmic reticulum membrane; TAS:Reactome.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0030176	integral component of endoplasmic reticulum membrane; IDA:UniProtKB.
# GO_function	G6PT1_HUMAN	GO 0061513 glucose 6-phosphate inorganic phosphate antiporter activity; IDA UniProtKB.
# GO_function	GO:0005215	transporter activity; NAS:UniProtKB.
# GO_function	GO:0015152	glucose-6-phosphate transmembrane transporter activity; IDA:UniProtKB.
# GO_process	GO:0006006	glucose metabolic process; NAS:UniProtKB.
# GO_process	GO:0006810	transport; NAS:UniProtKB.
# GO_process	GO:0015758	glucose transport; TAS:Reactome.
# GO_process	GO:0015760	glucose-6-phosphate transport; IDA:UniProtKB.
# GO_process	GO:0035435	phosphate ion transmembrane transport; IDA:UniProtKB.
# GO_process	GO:0042593	glucose homeostasis; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0005975	carbohydrate metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# HGNC	HGNC:4061	SLC37A4
# IntAct	O43826	2
# InterPro	IPR000849	Sugar_P_transporter
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# InterPro	IPR021159	Sugar-P_transporter_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H00069	[Inherited metabolic disease] Glycogen synthase deficiency (GSD type 0)
# KEGG_Pathway	ko04973	Carbohydrate digestion and absorption
# MIM	232220	phenotype
# MIM	232240	phenotype
# MIM	602671	gene
# Organism	G6PT1_HUMAN	Homo sapiens (Human)
# Orphanet	79259	Glycogen storage disease due to glucose-6-phosphatase deficiency type b
# PIRSF	PIRSF002808	Hexose_phosphate_transp
# PROSITE	PS00942	GLPT
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Unplaced
# Reactome	R-HSA-70153	Glucose transport
# RecName	G6PT1_HUMAN	Glucose-6-phosphate exchanger SLC37A4 {ECO 0000305|PubMed 10026167, ECO 0000305|PubMed 21949678}
# RefSeq	NP_001157749	NM_001164277.1. [O43826-1]
# RefSeq	NP_001157750	NM_001164278.1. [O43826-2]
# RefSeq	NP_001157751	NM_001164279.1
# RefSeq	NP_001157752	NM_001164280.1. [O43826-1]
# RefSeq	NP_001458	NM_001467.5. [O43826-1]
# SEQUENCE CAUTION	Sequence=AAF16691.1; Type=Frameshift; Positions=128; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	G6PT1_HUMAN	Endoplasmic reticulum membrane {ECO 0000269|PubMed 21949678}; Multi-pass membrane protein {ECO 0000255}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.4	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	G6PT1_HUMAN	Mostly expressed in liver and kidney. 
# WEB RESOURCE	G6PT1_HUMAN	Name=Mendelian genes solute carrier family 37 (glucose-6-phosphate transporter), member 4 (SLC37A4); Note=Leiden Open Variation Database (LOVD); URL="http //www.lovd.nl/SLC37A4";
BLAST	swissprot:G6PT1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:G6PT1_HUMAN
BioCyc	ZFISH:ENSG00000137700-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000137700-MONOMER
COXPRESdb	2542	http://coxpresdb.jp/data/gene/2542.shtml
CleanEx	HS_SLC37A4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC37A4
DOI	10.1002/(SICI)1096-8628(19990917)86:3<253::AID-AJMG11>3.0.CO	http://dx.doi.org/10.1002/(SICI)1096-8628(19990917)86:3<253::AID-AJMG11>3.0.CO
DOI	10.1002/1098-1004(200007)16:1<94::AID-HUMU26>3.0.CO	http://dx.doi.org/10.1002/1098-1004(200007)16:1<94::AID-HUMU26>3.0.CO
DOI	10.1002/1098-1004(200008)16:2<177::AID-HUMU13>3.0.CO	http://dx.doi.org/10.1002/1098-1004(200008)16:2<177::AID-HUMU13>3.0.CO
DOI	10.1006/bbrc.1998.8985	http://dx.doi.org/10.1006/bbrc.1998.8985
DOI	10.1007/s004390000371	http://dx.doi.org/10.1007/s004390000371
DOI	10.1007/s004390050856	http://dx.doi.org/10.1007/s004390050856
DOI	10.1007/s004390050948	http://dx.doi.org/10.1007/s004390050948
DOI	10.1016/S0014-5793(97)01463-4	http://dx.doi.org/10.1016/S0014-5793(97)01463-4
DOI	10.1016/S0014-5793(98)01129-6	http://dx.doi.org/10.1016/S0014-5793(98)01129-6
DOI	10.1016/S0014-5793(99)01248-X	http://dx.doi.org/10.1016/S0014-5793(99)01248-X
DOI	10.1016/S0378-1119(98)00614-3	http://dx.doi.org/10.1016/S0378-1119(98)00614-3
DOI	10.1016/S1096-7192(02)00110-5	http://dx.doi.org/10.1016/S1096-7192(02)00110-5
DOI	10.1016/S1875-9572(09)60048-6	http://dx.doi.org/10.1016/S1875-9572(09)60048-6
DOI	10.1016/j.ymgme.2003.12.004	http://dx.doi.org/10.1016/j.ymgme.2003.12.004
DOI	10.1023/B:BOLI.0000042987.43395.c6	http://dx.doi.org/10.1023/B:BOLI.0000042987.43395.c6
DOI	10.1038/sj.ejhg.5200366	http://dx.doi.org/10.1038/sj.ejhg.5200366
DOI	10.1067/mpd.2000.107472	http://dx.doi.org/10.1067/mpd.2000.107472
DOI	10.1074/jbc.274.9.5532	http://dx.doi.org/10.1074/jbc.274.9.5532
DOI	10.1086/302068	http://dx.doi.org/10.1086/302068
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1371/journal.pone.0023157	http://dx.doi.org/10.1371/journal.pone.0023157
DOI	10.2174/1566524024605798	http://dx.doi.org/10.2174/1566524024605798
DOI	10.3346/jkms.2005.20.3.499	http://dx.doi.org/10.3346/jkms.2005.20.3.499
DOI	10.4172/1747-0862.1000046	http://dx.doi.org/10.4172/1747-0862.1000046
EMBL	AF078163	http://www.ebi.ac.uk/ena/data/view/AF078163
EMBL	AF097831	http://www.ebi.ac.uk/ena/data/view/AF097831
EMBL	AF110819	http://www.ebi.ac.uk/ena/data/view/AF110819
EMBL	AF110820	http://www.ebi.ac.uk/ena/data/view/AF110820
EMBL	AF111852	http://www.ebi.ac.uk/ena/data/view/AF111852
EMBL	AF116862	http://www.ebi.ac.uk/ena/data/view/AF116862
EMBL	AF116863	http://www.ebi.ac.uk/ena/data/view/AF116863
EMBL	AF116864	http://www.ebi.ac.uk/ena/data/view/AF116864
EMBL	AY423732	http://www.ebi.ac.uk/ena/data/view/AY423732
EMBL	BC002400	http://www.ebi.ac.uk/ena/data/view/BC002400
EMBL	BC003589	http://www.ebi.ac.uk/ena/data/view/BC003589
EMBL	BC014663	http://www.ebi.ac.uk/ena/data/view/BC014663
EMBL	BC015650	http://www.ebi.ac.uk/ena/data/view/BC015650
EMBL	BC064563	http://www.ebi.ac.uk/ena/data/view/BC064563
EMBL	CH471065	http://www.ebi.ac.uk/ena/data/view/CH471065
EMBL	Y15409	http://www.ebi.ac.uk/ena/data/view/Y15409
EMBL	Y17864	http://www.ebi.ac.uk/ena/data/view/Y17864
Ensembl	ENST00000631372	http://www.ensembl.org/id/ENST00000631372
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030176	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030176
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0015152	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015152
GO_function	GO:0061513	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061513
GO_process	GO:0006006	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006006
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0015758	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015758
GO_process	GO:0015760	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015760
GO_process	GO:0035435	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035435
GO_process	GO:0042593	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042593
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC37A4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC37A4
GeneID	2542	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2542
HGNC	HGNC:4061	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4061
HOGENOM	HOG000274730	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274730&db=HOGENOM6
HOVERGEN	HBG051682	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051682&db=HOVERGEN
HPA	HPA038939	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA038939
HPA	HPA038940	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA038940
InParanoid	O43826	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O43826
IntAct	O43826	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O43826*
InterPro	IPR000849	http://www.ebi.ac.uk/interpro/entry/IPR000849
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
InterPro	IPR021159	http://www.ebi.ac.uk/interpro/entry/IPR021159
Jabion	2542	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2542
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00069	http://www.genome.jp/dbget-bin/www_bget?H00069
KEGG_Gene	hsa:2542	http://www.genome.jp/dbget-bin/www_bget?hsa:2542
KEGG_Orthology	KO:K08171	http://www.genome.jp/dbget-bin/www_bget?KO:K08171
KEGG_Pathway	ko04973	http://www.genome.jp/kegg-bin/show_pathway?ko04973
MIM	232220	http://www.ncbi.nlm.nih.gov/omim/232220
MIM	232240	http://www.ncbi.nlm.nih.gov/omim/232240
MIM	602671	http://www.ncbi.nlm.nih.gov/omim/602671
OMA	DISHAGW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DISHAGW
Orphanet	79259	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=79259
OrthoDB	EOG091G06B9	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G06B9
PROSITE	PS00942	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00942
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:G6PT1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:G6PT1_HUMAN
PSORT-B	swissprot:G6PT1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:G6PT1_HUMAN
PSORT2	swissprot:G6PT1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:G6PT1_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA28472	http://www.pharmgkb.org/do/serve?objId=PA28472&objCls=Gene
Phobius	swissprot:G6PT1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:G6PT1_HUMAN
PhylomeDB	O43826	http://phylomedb.org/?seqid=O43826
ProteinModelPortal	O43826	http://www.proteinmodelportal.org/query/uniprot/O43826
PubMed	10023055	http://www.ncbi.nlm.nih.gov/pubmed/10023055
PubMed	10026167	http://www.ncbi.nlm.nih.gov/pubmed/10026167
PubMed	10323254	http://www.ncbi.nlm.nih.gov/pubmed/10323254
PubMed	10482875	http://www.ncbi.nlm.nih.gov/pubmed/10482875
PubMed	10482962	http://www.ncbi.nlm.nih.gov/pubmed/10482962
PubMed	10518030	http://www.ncbi.nlm.nih.gov/pubmed/10518030
PubMed	10874322	http://www.ncbi.nlm.nih.gov/pubmed/10874322
PubMed	10923042	http://www.ncbi.nlm.nih.gov/pubmed/10923042
PubMed	10931421	http://www.ncbi.nlm.nih.gov/pubmed/10931421
PubMed	11071391	http://www.ncbi.nlm.nih.gov/pubmed/11071391
PubMed	11949931	http://www.ncbi.nlm.nih.gov/pubmed/11949931
PubMed	12409273	http://www.ncbi.nlm.nih.gov/pubmed/12409273
PubMed	15059622	http://www.ncbi.nlm.nih.gov/pubmed/15059622
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15669677	http://www.ncbi.nlm.nih.gov/pubmed/15669677
PubMed	15953877	http://www.ncbi.nlm.nih.gov/pubmed/15953877
PubMed	19579760	http://www.ncbi.nlm.nih.gov/pubmed/19579760
PubMed	21629566	http://www.ncbi.nlm.nih.gov/pubmed/21629566
PubMed	21949678	http://www.ncbi.nlm.nih.gov/pubmed/21949678
PubMed	9428641	http://www.ncbi.nlm.nih.gov/pubmed/9428641
PubMed	9675154	http://www.ncbi.nlm.nih.gov/pubmed/9675154
PubMed	9758626	http://www.ncbi.nlm.nih.gov/pubmed/9758626
PubMed	9781688	http://www.ncbi.nlm.nih.gov/pubmed/9781688
PubMed	9856496	http://www.ncbi.nlm.nih.gov/pubmed/9856496
Reactome	R-HSA-70153	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-70153
RefSeq	NP_001157749	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001157749
RefSeq	NP_001157750	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001157750
RefSeq	NP_001157751	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001157751
RefSeq	NP_001157752	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001157752
RefSeq	NP_001458	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001458
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.4	http://www.tcdb.org/search/result.php?tc=2.A.1.4
UniGene	Hs.719203	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.719203
UniProtKB	G6PT1_HUMAN	http://www.uniprot.org/uniprot/G6PT1_HUMAN
UniProtKB-AC	O43826	http://www.uniprot.org/uniprot/O43826
charge	swissprot:G6PT1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:G6PT1_HUMAN
epestfind	swissprot:G6PT1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:G6PT1_HUMAN
garnier	swissprot:G6PT1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:G6PT1_HUMAN
helixturnhelix	swissprot:G6PT1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:G6PT1_HUMAN
hmoment	swissprot:G6PT1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:G6PT1_HUMAN
iep	swissprot:G6PT1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:G6PT1_HUMAN
inforesidue	swissprot:G6PT1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:G6PT1_HUMAN
neXtProt	NX_O43826	http://www.nextprot.org/db/entry/NX_O43826
octanol	swissprot:G6PT1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:G6PT1_HUMAN
pepcoil	swissprot:G6PT1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:G6PT1_HUMAN
pepdigest	swissprot:G6PT1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:G6PT1_HUMAN
pepinfo	swissprot:G6PT1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:G6PT1_HUMAN
pepnet	swissprot:G6PT1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:G6PT1_HUMAN
pepstats	swissprot:G6PT1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:G6PT1_HUMAN
pepwheel	swissprot:G6PT1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:G6PT1_HUMAN
pepwindow	swissprot:G6PT1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:G6PT1_HUMAN
sigcleave	swissprot:G6PT1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:G6PT1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=PSD95-alpha; IsoId=P78352-1; Sequence=Displayed; Name=2; Synonyms=PSD95-beta; IsoId=P78352-2; Sequence=VSP_014929; Note=Ref.3 (AAD56173) sequence is in conflict in position: 46	E->V. {ECO:0000305}; Name=3; IsoId=P78352-3; Sequence=VSP_047247; 
# AltName	DLG4_HUMAN	Postsynaptic density protein 95
# AltName	DLG4_HUMAN	Synapse-associated protein 90
# BioGrid	108086	85
# CCDS	CCDS45599	-. [P78352-2]
# CCDS	CCDS45600	-. [P78352-3]
# CCDS	CCDS82050	-. [P78352-1]
# ChiTaRS	DLG4	human
# DOMAIN	DLG4_HUMAN	The L27 domain near the N-terminus of isoform 2 is required for HGS/HRS-dependent targeting to postsynaptic density. 
# DOMAIN	DLG4_HUMAN	The PDZ domain 3 mediates interaction with ADR1B. 
# DrugBank	DB00536	Guanidine
# Ensembl	ENST00000302955	ENSP00000307471; ENSG00000132535. [P78352-3]
# Ensembl	ENST00000399506	ENSP00000382425; ENSG00000132535. [P78352-1]
# Ensembl	ENST00000399510	ENSP00000382428; ENSG00000132535. [P78352-2]
# ExpressionAtlas	P78352	baseline and differential
# FUNCTION	DLG4_HUMAN	Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity). {ECO 0000250}. 
# GO_component	GO:0005737	cytoplasm; ISS:BHF-UCL.
# GO_component	GO:0005783	endoplasmic reticulum; ISS:BHF-UCL.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008021	synaptic vesicle; ISS:BHF-UCL.
# GO_component	GO:0014069	postsynaptic density; ISS:UniProtKB.
# GO_component	GO:0016323	basolateral plasma membrane; IBA:GO_Central.
# GO_component	GO:0030054	cell junction; ISS:BHF-UCL.
# GO_component	GO:0030666	endocytic vesicle membrane; TAS:Reactome.
# GO_component	GO:0030863	cortical cytoskeleton; IDA:UniProtKB.
# GO_component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane; ISS:BHF-UCL.
# GO_component	GO:0032281	AMPA glutamate receptor complex; ISS:BHF-UCL.
# GO_component	GO:0032839	dendrite cytoplasm; ISS:BHF-UCL.
# GO_component	GO:0043197	dendritic spine; ISS:ParkinsonsUK-UCL.
# GO_component	GO:0044224	juxtaparanode region of axon; ISS:BHF-UCL.
# GO_component	GO:0044300	cerebellar mossy fiber; IEA:Ensembl.
# GO_component	GO:0044306	neuron projection terminus; ISS:BHF-UCL.
# GO_component	GO:0044309	neuron spine; ISS:BHF-UCL.
# GO_component	GO:0045202	synapse; IDA:BHF-UCL.
# GO_component	GO:0045211	postsynaptic membrane; IDA:UniProtKB.
# GO_component	GO:0060076	excitatory synapse; ISS:BHF-UCL.
# GO_function	GO:0004385	guanylate kinase activity; IBA:GO_Central.
# GO_function	GO:0005088	Ras guanyl-nucleotide exchange factor activity; TAS:Reactome.
# GO_function	GO:0008022	protein C-terminus binding; IPI:UniProtKB.
# GO_function	GO:0015276	ligand-gated ion channel activity; TAS:Reactome.
# GO_function	GO:0019900	kinase binding; IDA:MGI.
# GO_function	GO:0019903	protein phosphatase binding; ISS:BHF-UCL.
# GO_function	GO:0030165	PDZ domain binding; ISS:BHF-UCL.
# GO_function	GO:0031697	beta-1 adrenergic receptor binding; ISS:BHF-UCL.
# GO_function	GO:0031748	D1 dopamine receptor binding; ISS:BHF-UCL.
# GO_function	GO:0031812	P2Y1 nucleotide receptor binding; ISS:BHF-UCL.
# GO_function	GO:0032403	protein complex binding; ISS:BHF-UCL.
# GO_function	GO:0033130	acetylcholine receptor binding; ISS:BHF-UCL.
# GO_function	GO:0035255	ionotropic glutamate receptor binding; ISS:BHF-UCL.
# GO_function	GO:0097109	neuroligin family protein binding; ISS:BHF-UCL.
# GO_function	GO:0097110	scaffold protein binding; ISS:BHF-UCL.
# GO_process	GO:0000165	MAPK cascade; TAS:Reactome.
# GO_process	GO:0002091	negative regulation of receptor internalization; ISS:BHF-UCL.
# GO_process	GO:0006461	protein complex assembly; IDA:BHF-UCL.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0007204	positive regulation of cytosolic calcium ion concentration; ISS:BHF-UCL.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:Reactome.
# GO_process	GO:0007399	nervous system development; TAS:ProtInc.
# GO_process	GO:0007612	learning; TAS:ProtInc.
# GO_process	GO:0016188	synaptic vesicle maturation; ISS:BHF-UCL.
# GO_process	GO:0035176	social behavior; IEA:Ensembl.
# GO_process	GO:0035418	protein localization to synapse; IDA:BHF-UCL.
# GO_process	GO:0035641	locomotory exploration behavior; IEA:Ensembl.
# GO_process	GO:0045184	establishment of protein localization; IDA:BHF-UCL.
# GO_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity; IBA:GO_Central.
# GO_process	GO:0048169	regulation of long-term neuronal synaptic plasticity; ISS:BHF-UCL.
# GO_process	GO:0050806	positive regulation of synaptic transmission; ISS:BHF-UCL.
# GO_process	GO:0050885	neuromuscular process controlling balance; IEA:Ensembl.
# GO_process	GO:0060997	dendritic spine morphogenesis; ISS:BHF-UCL.
# GO_process	GO:0071625	vocalization behavior; IEA:Ensembl.
# GO_process	GO:0097113	AMPA glutamate receptor clustering; ISS:BHF-UCL.
# GO_process	GO:0097120	receptor localization to synapse; ISS:BHF-UCL.
# GO_process	GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity; ISS:BHF-UCL.
# GO_process	GO:2000463	positive regulation of excitatory postsynaptic potential; ISS:BHF-UCL.
# GO_process	GO:2000821	regulation of grooming behavior; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005856	cytoskeleton
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016301	kinase activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0021700	developmental maturation
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0061024	membrane organization
# Gene3D	2.30.42.10	-; 3.
# Gene3D	3.40.50.300	-; 2.
# Genevisible	P78352	HS
# HGNC	HGNC:2903	DLG4
# INTERACTION	DLG4_HUMAN	Q9P021 CRIPT; NbExp=4; IntAct=EBI-80389, EBI-946968; O14490 DLGAP1; NbExp=5; IntAct=EBI-80389, EBI-1753207; P97836-5 Dlgap1 (xeno); NbExp=3; IntAct=EBI-80389, EBI-6269434; Q15303 ERBB4; NbExp=6; IntAct=EBI-80389, EBI-80371; Q8VDU0 Gpsm2 (xeno); NbExp=7; IntAct=EBI-80389, EBI-7575403; Q12879 GRIN2A; NbExp=3; IntAct=EBI-80389, EBI-7249937; Q13224 GRIN2B; NbExp=2; IntAct=EBI-80389, EBI-2256942; Q14957 GRIN2C; NbExp=4; IntAct=EBI-80389, EBI-8285963; Q09470 KCNA1; NbExp=2; IntAct=EBI-80389, EBI-8286599; P10499 Kcna1 (xeno); NbExp=2; IntAct=EBI-80389, EBI-631463; P63142 Kcna2 (xeno); NbExp=2; IntAct=EBI-80389, EBI-631446; P15384 Kcna3 (xeno); NbExp=2; IntAct=EBI-80389, EBI-631478; P22459 KCNA4; NbExp=2; IntAct=EBI-80389, EBI-631235; P15385 Kcna4 (xeno); NbExp=9; IntAct=EBI-80389, EBI-631417; O60333-3 KIF1B; NbExp=4; IntAct=EBI-80389, EBI-465669; Q00987 MDM2; NbExp=3; IntAct=EBI-80389, EBI-389668; 
# IntAct	P78352	33
# InterPro	IPR001452	SH3_domain
# InterPro	IPR001478	PDZ
# InterPro	IPR008144	Guanylate_kin-like_dom
# InterPro	IPR008145	GK/Ca_channel_bsu
# InterPro	IPR016313	DLG1
# InterPro	IPR019583	PDZ_assoc
# InterPro	IPR019590	DLG1_PEST_dom
# InterPro	IPR020590	Guanylate_kinase_CS
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04516	 Cell adhesion molecules and their ligands
# KEGG_Pathway	ko04390	Hippo signaling pathway
# KEGG_Pathway	ko04724	Glutamatergic synapse
# KEGG_Pathway	ko05016	Huntington's disease
# KEGG_Pathway	ko05030	Cocaine addiction
# MIM	602887	gene
# Organism	DLG4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR23119:SF33	PTHR23119:SF33
# PDB	1KEF	NMR; -; A=62-154
# PDB	2MES	NMR; -; B=1-71
# PDB	3I4W	X-ray; 1.35 A; A/B/C/D=302-403
# PDB	3K82	X-ray; 1.40 A; A=305-402
# PDB	3ZRT	X-ray; 3.40 A; A/B/C/D=61-249
# PDB	5JXB	X-ray; 2.90 A; A/C=309-413
# PIR	T09599	T09599
# PROSITE	PS00856	GUANYLATE_KINASE_1
# PROSITE	PS50002	SH3
# PROSITE	PS50052	GUANYLATE_KINASE_2
# PROSITE	PS50106	PDZ; 3
# PTM	DLG4_HUMAN	Palmitoylation of isoform 1 is required for targeting to postsynaptic density. {ECO 0000250}. 
# Pfam	PF00018	SH3_1
# Pfam	PF00595	PDZ; 3
# Pfam	PF00625	Guanylate_kin
# Pfam	PF10600	PDZ_assoc
# Pfam	PF10608	MAGUK_N_PEST
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-399719	Trafficking of AMPA receptors
# Reactome	R-HSA-438066	Unblocking of NMDA receptor, glutamate binding and activation
# Reactome	R-HSA-442729	CREB phosphorylation through the activation of CaMKII
# Reactome	R-HSA-442982	Ras activation uopn Ca2+ infux through NMDA receptor
# Reactome	R-HSA-447038	NrCAM interactions
# Reactome	R-HSA-451308	Activation of Ca-permeable Kainate Receptor
# Reactome	R-HSA-5625900	RHO GTPases activate CIT
# Reactome	R-HSA-5673001	RAF/MAP kinase cascade
# Reactome	R-HSA-5682910	LGI-ADAM interactions
# Reactome	R-HSA-6794361	Interactions of neurexins and neuroligins at synapses
# Reactome	R-HSA-8849932	SALM protein interactions at the synapses
# RecName	DLG4_HUMAN	Disks large homolog 4
# RefSeq	NP_001122299	NM_001128827.2. [P78352-3]
# RefSeq	NP_001308004	NM_001321075.1. [P78352-1]
# RefSeq	NP_001356	NM_001365.4. [P78352-2]
# SIMILARITY	Belongs to the MAGUK family. {ECO	0000305}. 
# SIMILARITY	Contains 1 SH3 domain. {ECO:0000255|PROSITE- ProRule	PRU00192}.
# SIMILARITY	Contains 1 guanylate kinase-like domain. {ECO:0000255|PROSITE-ProRule	PRU00100}. 
# SIMILARITY	Contains 3 PDZ (DHR) domains. {ECO:0000255|PROSITE- ProRule	PRU00143}. 
# SMART	SM00072	GuKc
# SMART	SM00228	PDZ; 3
# SMART	SM00326	SH3
# SMART	SM01277	MAGUK_N_PEST
# SUBCELLULAR LOCATION	DLG4_HUMAN	Cell membrane {ECO 0000269|PubMed 12151521}; Peripheral membrane protein {ECO 0000269|PubMed 12151521}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO 0000269|PubMed 12151521}. Cell projection, axon {ECO 0000250|UniProtKB P31016}. Cell junction, synapse {ECO 0000269|PubMed 12151521}. Note=High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells. 
# SUBUNIT	DLG4_HUMAN	Interacts through its PDZ domains with ANO2 and NETO1. Interacts through its first two PDZ domains with GRIN2A, GRIN2B, GRIN2C, GRIN2D, ASIC3, certain splice forms of GRIN1, KCND2, CXADR, SYNGAP1, KCNA1, KCNA2, KCNA3, KCNA4, ERBB4, LRRC4; LRRC4B and SEMA4C. Interacts through its first PDZ domain with GRIK2, KCNA4 and CRIPT. Interacts through its second PDZ domain with the PDZ domain of NOS1 or the C-terminus of CAPON. Interacts through its third PDZ domain with NLGN1 and CRIPT, and probably with NLGN2 and NLGN3. Interacts through its guanylate kinase-like domain with DLGAP1/GKAP, DLGAP2, DLGAP3, DLGAP4, MAP1A, BEGAIN, SIPA1L1 and KIF13B. Isoform 2 interacts through an L27 domain with HGS/HRS and the first L27 domain of CASK. Interacts with ADR1B, ANKS1B and PRR7. May interact with HTR2A. Interacts with ADAM22, KLHL17 and LGI1. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4, but not with LRFN3 nor LRFN5. Interacts (via N-terminal tandem pair of PDZ domains) with GPER1 (via C- terminus tail motif); the interaction is direct and induces the increase of GPER1 protein levels residing at the plasma membrane surface in a estradiol-independent manner. Interacts (via N- terminus tandem pair of PDZ domains) with NOS1 (via N-terminal domain). Interacts with SHANK3. Interacts with KCNJ4 (By similarity). Interacts with GPR85 (PubMed 25780553). {ECO 0000250|UniProtKB P31016, ECO 0000269|PubMed 10725395, ECO 0000269|PubMed 10859302, ECO 0000269|PubMed 12151521, ECO 0000269|PubMed 16630835, ECO 0000269|PubMed 19118189, ECO 0000269|PubMed 25780553, ECO 0000269|PubMed 7477295, ECO 0000269|PubMed 9278515}. 
# SUPFAM	SSF50044	SSF50044
# SUPFAM	SSF50156	SSF50156; 3
# SUPFAM	SSF52540	SSF52540
# TCDB	8.A.24.1	the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family
# TISSUE SPECIFICITY	DLG4_HUMAN	Brain. 
# UCSC	uc002get	human. [P78352-1]
# eggNOG	COG0194	LUCA
# eggNOG	KOG0708	Eukaryota
BLAST	swissprot:DLG4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:DLG4_HUMAN
BioCyc	ZFISH:ENSG00000132535-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000132535-MONOMER
COXPRESdb	1742	http://coxpresdb.jp/data/gene/1742.shtml
CleanEx	HS_DLG4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_DLG4
DIP	DIP-30919N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-30919N
DOI	10.1006/geno.1997.4848	http://dx.doi.org/10.1006/geno.1997.4848
DOI	10.1016/j.neuron.2006.04.005	http://dx.doi.org/10.1016/j.neuron.2006.04.005
DOI	10.1038/378085a0	http://dx.doi.org/10.1038/378085a0
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1046/j.1471-4159.1999.0732250.x	http://dx.doi.org/10.1046/j.1471-4159.1999.0732250.x
DOI	10.1073/pnas.97.7.3596	http://dx.doi.org/10.1073/pnas.97.7.3596
DOI	10.1074/jbc.M000715200	http://dx.doi.org/10.1074/jbc.M000715200
DOI	10.1074/jbc.M109453200	http://dx.doi.org/10.1074/jbc.M109453200
DOI	10.1126/science.277.5331.1511	http://dx.doi.org/10.1126/science.277.5331.1511
DOI	10.1186/s13229-015-0012-5	http://dx.doi.org/10.1186/s13229-015-0012-5
DOI	10.1523/JNEUROSCI.3112-08.2008	http://dx.doi.org/10.1523/JNEUROSCI.3112-08.2008
DrugBank	DB00536	http://www.drugbank.ca/drugs/DB00536
EMBL	AC120057	http://www.ebi.ac.uk/ena/data/view/AC120057
EMBL	AF156495	http://www.ebi.ac.uk/ena/data/view/AF156495
EMBL	AK293835	http://www.ebi.ac.uk/ena/data/view/AK293835
EMBL	CH471108	http://www.ebi.ac.uk/ena/data/view/CH471108
EMBL	U68138	http://www.ebi.ac.uk/ena/data/view/U68138
EMBL	U83192	http://www.ebi.ac.uk/ena/data/view/U83192
Ensembl	ENST00000302955	http://www.ensembl.org/id/ENST00000302955
Ensembl	ENST00000399506	http://www.ensembl.org/id/ENST00000399506
Ensembl	ENST00000399510	http://www.ensembl.org/id/ENST00000399510
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008021
GO_component	GO:0014069	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014069
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030666
GO_component	GO:0030863	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030863
GO_component	GO:0031234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031234
GO_component	GO:0032281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032281
GO_component	GO:0032839	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032839
GO_component	GO:0043197	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043197
GO_component	GO:0044224	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044224
GO_component	GO:0044300	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044300
GO_component	GO:0044306	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044306
GO_component	GO:0044309	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044309
GO_component	GO:0045202	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045202
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_component	GO:0060076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060076
GO_function	GO:0004385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004385
GO_function	GO:0005088	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005088
GO_function	GO:0008022	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008022
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_function	GO:0019900	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019900
GO_function	GO:0019903	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019903
GO_function	GO:0030165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030165
GO_function	GO:0031697	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031697
GO_function	GO:0031748	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031748
GO_function	GO:0031812	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031812
GO_function	GO:0032403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032403
GO_function	GO:0033130	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033130
GO_function	GO:0035255	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035255
GO_function	GO:0097109	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097109
GO_function	GO:0097110	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097110
GO_process	GO:0000165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000165
GO_process	GO:0002091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002091
GO_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007204
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007399	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007399
GO_process	GO:0007612	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007612
GO_process	GO:0016188	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016188
GO_process	GO:0035176	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035176
GO_process	GO:0035418	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035418
GO_process	GO:0035641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035641
GO_process	GO:0045184	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045184
GO_process	GO:0045197	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045197
GO_process	GO:0048169	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048169
GO_process	GO:0050806	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050806
GO_process	GO:0050885	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050885
GO_process	GO:0060997	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060997
GO_process	GO:0071625	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071625
GO_process	GO:0097113	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097113
GO_process	GO:0097120	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097120
GO_process	GO:2000310	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000310
GO_process	GO:2000463	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000463
GO_process	GO:2000821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000821
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0021700	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021700
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
Gene3D	2.30.42.10	http://www.cathdb.info/version/latest/superfamily/2.30.42.10
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	DLG4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=DLG4
GeneID	1742	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1742
GeneTree	ENSGT00760000118866	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118866
HGNC	HGNC:2903	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2903
HOGENOM	HOG000232102	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000232102&db=HOGENOM6
HOVERGEN	HBG107814	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG107814&db=HOVERGEN
HPA	CAB001999	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB001999
HPA	CAB002000	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB002000
HPA	HPA010122	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA010122
InParanoid	P78352	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P78352
IntAct	P78352	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P78352*
InterPro	IPR001452	http://www.ebi.ac.uk/interpro/entry/IPR001452
InterPro	IPR001478	http://www.ebi.ac.uk/interpro/entry/IPR001478
InterPro	IPR008144	http://www.ebi.ac.uk/interpro/entry/IPR008144
InterPro	IPR008145	http://www.ebi.ac.uk/interpro/entry/IPR008145
InterPro	IPR016313	http://www.ebi.ac.uk/interpro/entry/IPR016313
InterPro	IPR019583	http://www.ebi.ac.uk/interpro/entry/IPR019583
InterPro	IPR019590	http://www.ebi.ac.uk/interpro/entry/IPR019590
InterPro	IPR020590	http://www.ebi.ac.uk/interpro/entry/IPR020590
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	1742	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1742
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04516	http://www.genome.jp/dbget-bin/www_bget?ko04516
KEGG_Gene	hsa:1742	http://www.genome.jp/dbget-bin/www_bget?hsa:1742
KEGG_Orthology	KO:K11828	http://www.genome.jp/dbget-bin/www_bget?KO:K11828
KEGG_Pathway	ko04390	http://www.genome.jp/kegg-bin/show_pathway?ko04390
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
KEGG_Pathway	ko05030	http://www.genome.jp/kegg-bin/show_pathway?ko05030
MIM	602887	http://www.ncbi.nlm.nih.gov/omim/602887
MINT	MINT-199061	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-199061
OMA	HREPRRI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HREPRRI
OrthoDB	EOG091G0BB1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0BB1
PANTHER	PTHR23119:SF33	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23119:SF33
PDB	1KEF	http://www.ebi.ac.uk/pdbe-srv/view/entry/1KEF
PDB	2MES	http://www.ebi.ac.uk/pdbe-srv/view/entry/2MES
PDB	3I4W	http://www.ebi.ac.uk/pdbe-srv/view/entry/3I4W
PDB	3K82	http://www.ebi.ac.uk/pdbe-srv/view/entry/3K82
PDB	3ZRT	http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZRT
PDB	5JXB	http://www.ebi.ac.uk/pdbe-srv/view/entry/5JXB
PDBsum	1KEF	http://www.ebi.ac.uk/pdbsum/1KEF
PDBsum	2MES	http://www.ebi.ac.uk/pdbsum/2MES
PDBsum	3I4W	http://www.ebi.ac.uk/pdbsum/3I4W
PDBsum	3K82	http://www.ebi.ac.uk/pdbsum/3K82
PDBsum	3ZRT	http://www.ebi.ac.uk/pdbsum/3ZRT
PDBsum	5JXB	http://www.ebi.ac.uk/pdbsum/5JXB
PROSITE	PS00856	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00856
PROSITE	PS50002	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50002
PROSITE	PS50052	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50052
PROSITE	PS50106	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50106
PSORT	swissprot:DLG4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:DLG4_HUMAN
PSORT-B	swissprot:DLG4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:DLG4_HUMAN
PSORT2	swissprot:DLG4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:DLG4_HUMAN
Pfam	PF00018	http://pfam.xfam.org/family/PF00018
Pfam	PF00595	http://pfam.xfam.org/family/PF00595
Pfam	PF00625	http://pfam.xfam.org/family/PF00625
Pfam	PF10600	http://pfam.xfam.org/family/PF10600
Pfam	PF10608	http://pfam.xfam.org/family/PF10608
PharmGKB	PA27359	http://www.pharmgkb.org/do/serve?objId=PA27359&objCls=Gene
Phobius	swissprot:DLG4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:DLG4_HUMAN
PhylomeDB	P78352	http://phylomedb.org/?seqid=P78352
ProteinModelPortal	P78352	http://www.proteinmodelportal.org/query/uniprot/P78352
PubMed	10582582	http://www.ncbi.nlm.nih.gov/pubmed/10582582
PubMed	10725395	http://www.ncbi.nlm.nih.gov/pubmed/10725395
PubMed	10859302	http://www.ncbi.nlm.nih.gov/pubmed/10859302
PubMed	11744724	http://www.ncbi.nlm.nih.gov/pubmed/11744724
PubMed	12151521	http://www.ncbi.nlm.nih.gov/pubmed/12151521
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	16630835	http://www.ncbi.nlm.nih.gov/pubmed/16630835
PubMed	19118189	http://www.ncbi.nlm.nih.gov/pubmed/19118189
PubMed	25780553	http://www.ncbi.nlm.nih.gov/pubmed/25780553
PubMed	7477295	http://www.ncbi.nlm.nih.gov/pubmed/7477295
PubMed	9278515	http://www.ncbi.nlm.nih.gov/pubmed/9278515
PubMed	9286702	http://www.ncbi.nlm.nih.gov/pubmed/9286702
Reactome	R-HSA-399719	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-399719
Reactome	R-HSA-438066	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-438066
Reactome	R-HSA-442729	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442729
Reactome	R-HSA-442982	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442982
Reactome	R-HSA-447038	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-447038
Reactome	R-HSA-451308	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-451308
Reactome	R-HSA-5625900	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5625900
Reactome	R-HSA-5673001	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5673001
Reactome	R-HSA-5682910	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5682910
Reactome	R-HSA-6794361	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6794361
Reactome	R-HSA-8849932	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8849932
RefSeq	NP_001122299	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001122299
RefSeq	NP_001308004	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001308004
RefSeq	NP_001356	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001356
SMART	SM00072	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00072
SMART	SM00228	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00228
SMART	SM00326	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00326
SMART	SM01277	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01277
SMR	P78352	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P78352
STRING	9606.ENSP00000293813	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000293813&targetmode=cogs
SUPFAM	SSF50044	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50044
SUPFAM	SSF50156	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50156
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TCDB	8.A.24.1	http://www.tcdb.org/search/result.php?tc=8.A.24.1
UCSC	uc002get	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002get&org=rat
UniGene	Hs.463928	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.463928
UniProtKB	DLG4_HUMAN	http://www.uniprot.org/uniprot/DLG4_HUMAN
UniProtKB-AC	P78352	http://www.uniprot.org/uniprot/P78352
charge	swissprot:DLG4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:DLG4_HUMAN
eggNOG	COG0194	http://eggnogapi.embl.de/nog_data/html/tree/COG0194
eggNOG	KOG0708	http://eggnogapi.embl.de/nog_data/html/tree/KOG0708
epestfind	swissprot:DLG4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:DLG4_HUMAN
garnier	swissprot:DLG4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:DLG4_HUMAN
helixturnhelix	swissprot:DLG4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:DLG4_HUMAN
hmoment	swissprot:DLG4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:DLG4_HUMAN
iep	swissprot:DLG4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:DLG4_HUMAN
inforesidue	swissprot:DLG4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:DLG4_HUMAN
neXtProt	NX_P78352	http://www.nextprot.org/db/entry/NX_P78352
octanol	swissprot:DLG4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:DLG4_HUMAN
pepcoil	swissprot:DLG4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:DLG4_HUMAN
pepdigest	swissprot:DLG4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:DLG4_HUMAN
pepinfo	swissprot:DLG4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:DLG4_HUMAN
pepnet	swissprot:DLG4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:DLG4_HUMAN
pepstats	swissprot:DLG4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:DLG4_HUMAN
pepwheel	swissprot:DLG4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:DLG4_HUMAN
pepwindow	swissprot:DLG4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:DLG4_HUMAN
sigcleave	swissprot:DLG4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:DLG4_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNV1_HUMAN	Neuronal potassium channel alpha subunit HNKA
# AltName	KCNV1_HUMAN	Voltage-gated potassium channel subunit Kv8.1
# BioGrid	117954	2
# DOMAIN	KCNV1_HUMAN	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. {ECO 0000250}. 
# Ensembl	ENST00000297404	ENSP00000297404; ENSG00000164794
# Ensembl	ENST00000524391	ENSP00000435954; ENSG00000164794
# FUNCTION	KCNV1_HUMAN	Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes. {ECO 0000269|PubMed 8670833, ECO 0000269|PubMed 9079713}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IEA:InterPro.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; IBA:GO_Central.
# GO_function	GO:0008200	ion channel inhibitor activity; TAS:ProtInc.
# GO_function	GO:0015459	potassium channel regulator activity; TAS:ProtInc.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0051260	protein homooligomerization; IEA:InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# Gene3D	1.20.120.350	-; 1.
# Genevisible	Q6PIU1	HS
# HGNC	HGNC:18861	KCNV1
# InterPro	IPR000210	BTB/POZ_dom
# InterPro	IPR003131	T1-type_BTB
# InterPro	IPR003968	K_chnl_volt-dep_Kv
# InterPro	IPR003970	K_chnl_volt-dep_Kv8.1
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR011333	SKP1/BTB/POZ
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko04040	Ion channels
# MIM	608164	gene
# Organism	KCNV1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11537	PTHR11537; 2
# PANTHER	PTHR11537:SF38	PTHR11537:SF38; 2
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01491	KVCHANNEL
# PRINTS	PR01493	KV8CHANNEL
# Pfam	PF00520	Ion_trans
# Pfam	PF02214	BTB_2
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# RecName	KCNV1_HUMAN	Potassium voltage-gated channel subfamily V member 1
# RefSeq	NP_055194	NM_014379.3
# SIMILARITY	Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily. {ECO	0000305}.
# SMART	SM00225	BTB
# SUBCELLULAR LOCATION	KCNV1_HUMAN	Cell membrane {ECO 0000269|PubMed 8670833, ECO 0000269|PubMed 9079713}; Multi-pass membrane protein {ECO 0000269|PubMed 8670833, ECO 0000269|PubMed 9079713}. Note=Has to be associated with another potassium channel subunit to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB2. 
# SUBUNIT	KCNV1_HUMAN	Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1. {ECO 0000269|PubMed 8670833, ECO 0000269|PubMed 9079713}. 
# SUPFAM	SSF54695	SSF54695
# TISSUE SPECIFICITY	Detected in brain. {ECO:0000269|PubMed	12383276}. 
# UCSC	uc003ynr	human
# eggNOG	COG1226	LUCA
# eggNOG	KOG3713	Eukaryota
BLAST	swissprot:KCNV1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNV1_HUMAN
COXPRESdb	27012	http://coxpresdb.jp/data/gene/27012.shtml
CleanEx	HS_KCNV1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNV1
DOI	10.1046/j.1528-1157.43.s.9.7.x	http://dx.doi.org/10.1046/j.1528-1157.43.s.9.7.x
DOI	10.1074/jbc.272.13.8774	http://dx.doi.org/10.1074/jbc.272.13.8774
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB032013	http://www.ebi.ac.uk/ena/data/view/AB032013
EMBL	AF167082	http://www.ebi.ac.uk/ena/data/view/AF167082
EMBL	BC028739	http://www.ebi.ac.uk/ena/data/view/BC028739
Ensembl	ENST00000297404	http://www.ensembl.org/id/ENST00000297404
Ensembl	ENST00000524391	http://www.ensembl.org/id/ENST00000524391
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_function	GO:0008200	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008200
GO_function	GO:0015459	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015459
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	KCNV1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNV1
GeneID	27012	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27012
GeneTree	ENSGT00760000118981	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118981
HGNC	HGNC:18861	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18861
HOGENOM	HOG000231016	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231016&db=HOGENOM6
HOVERGEN	HBG052230	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052230&db=HOVERGEN
InParanoid	Q6PIU1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6PIU1
IntAct	Q6PIU1	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q6PIU1*
InterPro	IPR000210	http://www.ebi.ac.uk/interpro/entry/IPR000210
InterPro	IPR003131	http://www.ebi.ac.uk/interpro/entry/IPR003131
InterPro	IPR003968	http://www.ebi.ac.uk/interpro/entry/IPR003968
InterPro	IPR003970	http://www.ebi.ac.uk/interpro/entry/IPR003970
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR011333	http://www.ebi.ac.uk/interpro/entry/IPR011333
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	27012	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=27012
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:27012	http://www.genome.jp/dbget-bin/www_bget?hsa:27012
KEGG_Orthology	KO:K04934	http://www.genome.jp/dbget-bin/www_bget?KO:K04934
MIM	608164	http://www.ncbi.nlm.nih.gov/omim/608164
OMA	GMTIAQC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GMTIAQC
OrthoDB	EOG091G0FP3	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0FP3
PANTHER	PTHR11537	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537
PANTHER	PTHR11537:SF38	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537:SF38
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01491	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01491
PRINTS	PR01493	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01493
PSORT	swissprot:KCNV1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNV1_HUMAN
PSORT-B	swissprot:KCNV1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNV1_HUMAN
PSORT2	swissprot:KCNV1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNV1_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF02214	http://pfam.xfam.org/family/PF02214
PharmGKB	PA38721	http://www.pharmgkb.org/do/serve?objId=PA38721&objCls=Gene
Phobius	swissprot:KCNV1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNV1_HUMAN
PhylomeDB	Q6PIU1	http://phylomedb.org/?seqid=Q6PIU1
ProteinModelPortal	Q6PIU1	http://www.proteinmodelportal.org/query/uniprot/Q6PIU1
PubMed	12383276	http://www.ncbi.nlm.nih.gov/pubmed/12383276
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	8670833	http://www.ncbi.nlm.nih.gov/pubmed/8670833
PubMed	9079713	http://www.ncbi.nlm.nih.gov/pubmed/9079713
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
RefSeq	NP_055194	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055194
SMART	SM00225	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225
STRING	9606.ENSP00000297404	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000297404&targetmode=cogs
SUPFAM	SSF54695	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54695
UCSC	uc003ynr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ynr&org=rat
UniGene	Hs.13285	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.13285
UniProtKB	KCNV1_HUMAN	http://www.uniprot.org/uniprot/KCNV1_HUMAN
UniProtKB-AC	Q6PIU1	http://www.uniprot.org/uniprot/Q6PIU1
charge	swissprot:KCNV1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNV1_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG3713	http://eggnogapi.embl.de/nog_data/html/tree/KOG3713
epestfind	swissprot:KCNV1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNV1_HUMAN
garnier	swissprot:KCNV1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNV1_HUMAN
helixturnhelix	swissprot:KCNV1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNV1_HUMAN
hmoment	swissprot:KCNV1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNV1_HUMAN
iep	swissprot:KCNV1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNV1_HUMAN
inforesidue	swissprot:KCNV1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNV1_HUMAN
neXtProt	NX_Q6PIU1	http://www.nextprot.org/db/entry/NX_Q6PIU1
octanol	swissprot:KCNV1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNV1_HUMAN
pepcoil	swissprot:KCNV1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNV1_HUMAN
pepdigest	swissprot:KCNV1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNV1_HUMAN
pepinfo	swissprot:KCNV1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNV1_HUMAN
pepnet	swissprot:KCNV1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNV1_HUMAN
pepstats	swissprot:KCNV1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNV1_HUMAN
pepwheel	swissprot:KCNV1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNV1_HUMAN
pepwindow	swissprot:KCNV1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNV1_HUMAN
sigcleave	swissprot:KCNV1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNV1_HUMAN
## Database	ID	URL or Descriptions
# AltName	CX7B2_HUMAN	Cytochrome c oxidase polypeptide VIIb2
# CDD	cd01403	Cyt_c_Oxidase_VIIb
# Ensembl	ENST00000355591	ENSP00000347799; ENSG00000170516
# Ensembl	ENST00000396533	ENSP00000379784; ENSG00000170516
# ExpressionAtlas	Q8TF08	baseline and differential
# FUNCTION	CX7B2_HUMAN	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. 
# GO_component	GO:0005739	mitochondrion; IBA:GO_Central.
# GO_component	GO:0005746	mitochondrial respiratory chain; IEA:InterPro.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0045277	respiratory chain complex IV; IBA:GO_Central.
# GO_function	GO:0004129	cytochrome-c oxidase activity; IEA:InterPro.
# GO_process	GO:1902600	hydrogen ion transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	4.10.51.10	-; 1.
# Genevisible	Q8TF08	HS
# HGNC	HGNC:24381	COX7B2
# InterPro	IPR008433	Cyt_c_oxidase_suVIIB
# InterPro	IPR023272	Cyt_c_oxidase_suVIIB_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	609811	gene
# Organism	CX7B2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR16716	PTHR16716
# Pfam	PF05392	COX7B
# Proteomes	UP000005640	Chromosome 4
# RecName	CX7B2_HUMAN	Cytochrome c oxidase subunit 7B2, mitochondrial
# RefSeq	NP_570972	NM_130902.2
# RefSeq	XP_005248113	XM_005248056.4
# RefSeq	XP_011511932	XM_011513630.2
# RefSeq	XP_011511933	XM_011513631.2
# RefSeq	XP_011511934	XM_011513632.2
# RefSeq	XP_011511935	XM_011513633.2
# RefSeq	XP_011511936	XM_011513634.2
# RefSeq	XP_011511937	XM_011513635.2
# RefSeq	XP_011511938	XM_011513636.1
# RefSeq	XP_011511939	XM_011513637.2
# RefSeq	XP_011511940	XM_011513638.2
# SEQUENCE CAUTION	Sequence=AAH35923.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI07856.1; Type=Erroneous initiation; Evidence={ECO	0000305}; Sequence=AAL75946.1; Type=Erroneous initiation; Evidence={ECO:0000305};
# SIMILARITY	Belongs to the cytochrome c oxidase VIIb family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	CX7B2_HUMAN	Mitochondrion inner membrane {ECO 0000250}. 
# SUPFAM	SSF81423	SSF81423
# TCDB	3.D.4.11	the proton-translocating cytochrome oxidase (cox) superfamily
# UCSC	uc003gxf	human
# eggNOG	ENOG410J3GK	Eukaryota
# eggNOG	ENOG4112BN9	LUCA
BLAST	swissprot:CX7B2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CX7B2_HUMAN
BioCyc	ZFISH:HS15893-MONOMER	http://biocyc.org/getid?id=ZFISH:HS15893-MONOMER
COXPRESdb	170712	http://coxpresdb.jp/data/gene/170712.shtml
CleanEx	HS_COX7B2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_COX7B2
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1360/03yc0037	http://dx.doi.org/10.1360/03yc0037
EMBL	AF125109	http://www.ebi.ac.uk/ena/data/view/AF125109
EMBL	BC035923	http://www.ebi.ac.uk/ena/data/view/BC035923
EMBL	BC107855	http://www.ebi.ac.uk/ena/data/view/BC107855
Ensembl	ENST00000355591	http://www.ensembl.org/id/ENST00000355591
Ensembl	ENST00000396533	http://www.ensembl.org/id/ENST00000396533
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005746	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005746
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0045277	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045277
GO_function	GO:0004129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004129
GO_process	GO:1902600	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902600
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	4.10.51.10	http://www.cathdb.info/version/latest/superfamily/4.10.51.10
GeneCards	COX7B2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=COX7B2
GeneID	170712	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=170712
GeneTree	ENSGT00390000012178	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000012178
HGNC	HGNC:24381	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:24381
HOGENOM	HOG000059529	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000059529&db=HOGENOM6
HOVERGEN	HBG051092	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051092&db=HOVERGEN
InParanoid	Q8TF08	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8TF08
InterPro	IPR008433	http://www.ebi.ac.uk/interpro/entry/IPR008433
InterPro	IPR023272	http://www.ebi.ac.uk/interpro/entry/IPR023272
Jabion	170712	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=170712
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Gene	hsa:170712	http://www.genome.jp/dbget-bin/www_bget?hsa:170712
KEGG_Orthology	KO:K02271	http://www.genome.jp/dbget-bin/www_bget?KO:K02271
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	609811	http://www.ncbi.nlm.nih.gov/omim/609811
OMA	KHSPDFH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KHSPDFH
OrthoDB	EOG091G1342	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G1342
PANTHER	PTHR16716	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16716
PSORT	swissprot:CX7B2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CX7B2_HUMAN
PSORT-B	swissprot:CX7B2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CX7B2_HUMAN
PSORT2	swissprot:CX7B2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CX7B2_HUMAN
Pfam	PF05392	http://pfam.xfam.org/family/PF05392
PharmGKB	PA134885922	http://www.pharmgkb.org/do/serve?objId=PA134885922&objCls=Gene
Phobius	swissprot:CX7B2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CX7B2_HUMAN
PhylomeDB	Q8TF08	http://phylomedb.org/?seqid=Q8TF08
ProteinModelPortal	Q8TF08	http://www.proteinmodelportal.org/query/uniprot/Q8TF08
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15623157	http://www.ncbi.nlm.nih.gov/pubmed/15623157
RefSeq	NP_570972	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_570972
RefSeq	XP_005248113	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005248113
RefSeq	XP_011511932	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011511932
RefSeq	XP_011511933	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011511933
RefSeq	XP_011511934	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011511934
RefSeq	XP_011511935	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011511935
RefSeq	XP_011511936	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011511936
RefSeq	XP_011511937	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011511937
RefSeq	XP_011511938	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011511938
RefSeq	XP_011511939	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011511939
RefSeq	XP_011511940	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011511940
SMR	Q8TF08	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8TF08
STRING	9606.ENSP00000305964	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000305964&targetmode=cogs
SUPFAM	SSF81423	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81423
TCDB	3.D.4.11	http://www.tcdb.org/search/result.php?tc=3.D.4.11
UCSC	uc003gxf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003gxf&org=rat
UniGene	Hs.479656	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.479656
UniProtKB	CX7B2_HUMAN	http://www.uniprot.org/uniprot/CX7B2_HUMAN
UniProtKB-AC	Q8TF08	http://www.uniprot.org/uniprot/Q8TF08
charge	swissprot:CX7B2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CX7B2_HUMAN
eggNOG	ENOG410J3GK	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410J3GK
eggNOG	ENOG4112BN9	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4112BN9
epestfind	swissprot:CX7B2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CX7B2_HUMAN
garnier	swissprot:CX7B2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CX7B2_HUMAN
helixturnhelix	swissprot:CX7B2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CX7B2_HUMAN
hmoment	swissprot:CX7B2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CX7B2_HUMAN
iep	swissprot:CX7B2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CX7B2_HUMAN
inforesidue	swissprot:CX7B2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CX7B2_HUMAN
neXtProt	NX_Q8TF08	http://www.nextprot.org/db/entry/NX_Q8TF08
octanol	swissprot:CX7B2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CX7B2_HUMAN
pepcoil	swissprot:CX7B2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CX7B2_HUMAN
pepdigest	swissprot:CX7B2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CX7B2_HUMAN
pepinfo	swissprot:CX7B2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CX7B2_HUMAN
pepnet	swissprot:CX7B2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CX7B2_HUMAN
pepstats	swissprot:CX7B2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CX7B2_HUMAN
pepwheel	swissprot:CX7B2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CX7B2_HUMAN
pepwindow	swissprot:CX7B2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CX7B2_HUMAN
sigcleave	swissprot:CX7B2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CX7B2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CLCKB_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P51801-1; Sequence=Displayed; Name=2; IsoId=P51801-2; Sequence=VSP_045965, VSP_045966, VSP_045967; Note=No experimental confirmation available.; 
# AltName	CLCKB_HUMAN	ClC-K2
# CCDS	CCDS168	-. [P51801-1]
# CCDS	CCDS57974	-. [P51801-2]
# ChiTaRS	CLCNKB	human
# DISEASE	CLCKB_HUMAN	Bartter syndrome 3 (BARTS3) [MIM 607364]  A form of Bartter syndrome, an autosomal recessive disorder characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. {ECO 0000269|PubMed 9326936}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CLCKB_HUMAN	Bartter syndrome 4B, neonatal, with sensorineural deafness (BARTS4B) [MIM 613090]  A digenic form of Bartter syndrome, an autosomal recessive disorder characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BARTS4B is associated with sensorineural deafness. {ECO 0000269|PubMed 15044642, ECO 0000269|PubMed 18310267}. Note=The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Loss-of-function of both CLCNKA and CLCNKB results in the disease phenotype (PubMed 18310267). {ECO 0000269|PubMed 18310267}. 
# Ensembl	ENST00000375667	ENSP00000364819; ENSG00000184908. [P51801-2]
# Ensembl	ENST00000375679	ENSP00000364831; ENSG00000184908. [P51801-1]
# ExpressionAtlas	P51801	baseline and differential
# FUNCTION	CLCKB_HUMAN	Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms. {ECO 0000269|PubMed 11734858}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_function	GO:0005247	voltage-gated chloride channel activity; TAS:Reactome.
# GO_function	GO:0031404	chloride ion binding; IBA:GO_Central.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007588	excretion; TAS:ProtInc.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:1902476	chloride transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.10.3080.10	-; 2.
# Genevisible	P51801	HS
# HGNC	HGNC:2027	CLCNKB
# InterPro	IPR000644	CBS_dom
# InterPro	IPR001807	Cl-channel_volt-gated
# InterPro	IPR002250	Cl_channel-K
# InterPro	IPR014743	Cl-channel_core
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00239	[Endocrine disease; Urinary system disease] Bartter syndrome
# KEGG_Pathway	ko04966	Collecting duct acid secretion
# MIM	602023	gene
# MIM	607364	phenotype
# MIM	613090	phenotype
# MISCELLANEOUS	CLCKB_HUMAN	Compared with CLCNKA/BSND, CLCNKB/BSND is more sensitive to pH and less responsive to Ca(2+). 
# Organism	CLCKB_HUMAN	Homo sapiens (Human)
# Orphanet	358	Gitelman syndrome
# Orphanet	89938	Infantile Bartter syndrome with sensorineural deafness
# Orphanet	93605	Classic Bartter syndrome
# PIR	D57713	D57713
# PRINTS	PR00762	CLCHANNEL
# PRINTS	PR01119	CLCHANNELKDY
# PROSITE	PS51371	CBS; 2
# Pfam	PF00571	CBS
# Pfam	PF00654	Voltage_CLC
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	CLCKB_HUMAN	Chloride channel protein ClC-Kb
# RefSeq	NP_000076	NM_000085.4. [P51801-1]
# RefSeq	NP_001159417	NM_001165945.2. [P51801-2]
# SIMILARITY	Belongs to the chloride channel (TC 2.A.49) family. CLCNKB subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 2 CBS domains. {ECO:0000255|PROSITE- ProRule	PRU00703}.
# SMART	SM00116	CBS; 2
# SUBCELLULAR LOCATION	CLCKB_HUMAN	Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Interacts with BSND. Forms heteromers with BSND in the thick ascending limb of Henle and more distal segments (By similarity). {ECO	0000250}. 
# SUPFAM	SSF81340	SSF81340; 2
# TISSUE SPECIFICITY	Expressed predominantly in the kidney. {ECO:0000269|PubMed	11734858}. 
# UCSC	uc001axx	human. [P51801-1]
# eggNOG	COG0038	LUCA
# eggNOG	KOG0476	Eukaryota
BLAST	swissprot:CLCKB_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CLCKB_HUMAN
BioCyc	ZFISH:G66-32518-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32518-MONOMER
COXPRESdb	1188	http://coxpresdb.jp/data/gene/1188.shtml
CleanEx	HS_CLCNKB	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CLCNKB
DOI	10.1038/35107099	http://dx.doi.org/10.1038/35107099
DOI	10.1038/ki.1995.439	http://dx.doi.org/10.1038/ki.1995.439
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1097-171	http://dx.doi.org/10.1038/ng1097-171
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1056/NEJMoa032843	http://dx.doi.org/10.1056/NEJMoa032843
DOI	10.1073/pnas.91.15.6943	http://dx.doi.org/10.1073/pnas.91.15.6943
DOI	10.1136/jmg.2007.052944	http://dx.doi.org/10.1136/jmg.2007.052944
EMBL	AK098217	http://www.ebi.ac.uk/ena/data/view/AK098217
EMBL	AL355994	http://www.ebi.ac.uk/ena/data/view/AL355994
EMBL	AL355994	http://www.ebi.ac.uk/ena/data/view/AL355994
EMBL	S80315	http://www.ebi.ac.uk/ena/data/view/S80315
EMBL	U93879	http://www.ebi.ac.uk/ena/data/view/U93879
EMBL	Z30644	http://www.ebi.ac.uk/ena/data/view/Z30644
Ensembl	ENST00000375667	http://www.ensembl.org/id/ENST00000375667
Ensembl	ENST00000375679	http://www.ensembl.org/id/ENST00000375679
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_function	GO:0005247	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005247
GO_function	GO:0031404	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031404
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007588
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.10.3080.10	http://www.cathdb.info/version/latest/superfamily/1.10.3080.10
GeneCards	CLCNKB	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CLCNKB
GeneID	1188	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1188
GeneTree	ENSGT00760000119109	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119109
H-InvDB	HIX0020336	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0020336
HGNC	HGNC:2027	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2027
HOGENOM	HOG000231297	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231297&db=HOGENOM6
HOVERGEN	HBG005332	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG005332&db=HOVERGEN
HPA	HPA057717	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA057717
InParanoid	P51801	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P51801
IntAct	P51801	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P51801*
InterPro	IPR000644	http://www.ebi.ac.uk/interpro/entry/IPR000644
InterPro	IPR001807	http://www.ebi.ac.uk/interpro/entry/IPR001807
InterPro	IPR002250	http://www.ebi.ac.uk/interpro/entry/IPR002250
InterPro	IPR014743	http://www.ebi.ac.uk/interpro/entry/IPR014743
Jabion	1188	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1188
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00239	http://www.genome.jp/dbget-bin/www_bget?H00239
KEGG_Gene	hsa:1188	http://www.genome.jp/dbget-bin/www_bget?hsa:1188
KEGG_Orthology	KO:K05018	http://www.genome.jp/dbget-bin/www_bget?KO:K05018
KEGG_Pathway	ko04966	http://www.genome.jp/kegg-bin/show_pathway?ko04966
MIM	602023	http://www.ncbi.nlm.nih.gov/omim/602023
MIM	607364	http://www.ncbi.nlm.nih.gov/omim/607364
MIM	613090	http://www.ncbi.nlm.nih.gov/omim/613090
MINT	MINT-7969230	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-7969230
OMA	CQRIFFG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CQRIFFG
Orphanet	358	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=358
Orphanet	89938	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=89938
Orphanet	93605	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=93605
OrthoDB	EOG091G01RJ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01RJ
PRINTS	PR00762	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00762
PRINTS	PR01119	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01119
PROSITE	PS51371	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51371
PSORT	swissprot:CLCKB_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CLCKB_HUMAN
PSORT-B	swissprot:CLCKB_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CLCKB_HUMAN
PSORT2	swissprot:CLCKB_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CLCKB_HUMAN
Pfam	PF00571	http://pfam.xfam.org/family/PF00571
Pfam	PF00654	http://pfam.xfam.org/family/PF00654
PharmGKB	PA26554	http://www.pharmgkb.org/do/serve?objId=PA26554&objCls=Gene
Phobius	swissprot:CLCKB_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CLCKB_HUMAN
PhylomeDB	P51801	http://phylomedb.org/?seqid=P51801
ProteinModelPortal	P51801	http://www.proteinmodelportal.org/query/uniprot/P51801
PubMed	11734858	http://www.ncbi.nlm.nih.gov/pubmed/11734858
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15044642	http://www.ncbi.nlm.nih.gov/pubmed/15044642
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	18310267	http://www.ncbi.nlm.nih.gov/pubmed/18310267
PubMed	8041726	http://www.ncbi.nlm.nih.gov/pubmed/8041726
PubMed	8544406	http://www.ncbi.nlm.nih.gov/pubmed/8544406
PubMed	9326936	http://www.ncbi.nlm.nih.gov/pubmed/9326936
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_000076	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000076
RefSeq	NP_001159417	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001159417
SMART	SM00116	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00116
SMR	P51801	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P51801
STRING	9606.ENSP00000364831	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000364831&targetmode=cogs
SUPFAM	SSF81340	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81340
UCSC	uc001axx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001axx&org=rat
UniGene	Hs.352243	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.352243
UniProtKB	CLCKB_HUMAN	http://www.uniprot.org/uniprot/CLCKB_HUMAN
UniProtKB-AC	P51801	http://www.uniprot.org/uniprot/P51801
charge	swissprot:CLCKB_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CLCKB_HUMAN
eggNOG	COG0038	http://eggnogapi.embl.de/nog_data/html/tree/COG0038
eggNOG	KOG0476	http://eggnogapi.embl.de/nog_data/html/tree/KOG0476
epestfind	swissprot:CLCKB_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CLCKB_HUMAN
garnier	swissprot:CLCKB_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CLCKB_HUMAN
helixturnhelix	swissprot:CLCKB_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLCKB_HUMAN
hmoment	swissprot:CLCKB_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CLCKB_HUMAN
iep	swissprot:CLCKB_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CLCKB_HUMAN
inforesidue	swissprot:CLCKB_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CLCKB_HUMAN
neXtProt	NX_P51801	http://www.nextprot.org/db/entry/NX_P51801
octanol	swissprot:CLCKB_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CLCKB_HUMAN
pepcoil	swissprot:CLCKB_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CLCKB_HUMAN
pepdigest	swissprot:CLCKB_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CLCKB_HUMAN
pepinfo	swissprot:CLCKB_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CLCKB_HUMAN
pepnet	swissprot:CLCKB_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CLCKB_HUMAN
pepstats	swissprot:CLCKB_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CLCKB_HUMAN
pepwheel	swissprot:CLCKB_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CLCKB_HUMAN
pepwindow	swissprot:CLCKB_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CLCKB_HUMAN
sigcleave	swissprot:CLCKB_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CLCKB_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GLRA2_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=Alpha-2*; IsoId=P23416-1; Sequence=Displayed; Name=Alpha-2B; IsoId=P23416-2; Sequence=VSP_000082; Name=3; IsoId=P23416-3; Sequence=VSP_045465; Note=No experimental confirmation available.; 
# BIOPHYSICOCHEMICAL PROPERTIES	Kinetic parameters	 Note=For isoform Alpha-2* homopentamers, a concentration of about 66 uM glycine results in half-maximal channel conductance. For isoform Alpha-2B homopentamers, a concentration of about 34 uM glycine results in half-maximal channel conductance.; 
# BioGrid	109004	27
# CCDS	CCDS14160	-. [P23416-1]
# CCDS	CCDS48085	-. [P23416-2]
# CCDS	CCDS55371	-. [P23416-3]
# ChiTaRS	GLRA2	human
# DrugBank	DB00145	Glycine
# DrugBank	DB00431	Lindane
# DrugBank	DB00898	Ethanol
# ENZYME REGULATION	GLRA2_HUMAN	Inhibited by strychnine (PubMed 2155780, PubMed 15302677). Inhibited by picrotoxin (PubMed 15302677). Channel activity is potentiated by 10-100 uM Zn(2+) (PubMed 15302677, PubMed 16144831, PubMed 23895467). Channel activity is marginally increased by 50 mM ethanol; it is strongly increased by a combination of 0.5 uM Zn(2+) and 50 mM ethanol (PubMed 23895467). Channel activity is inhibited by 100-1000 uM Zn(2+) (PubMed 15302677). {ECO 0000269|PubMed 15302677, ECO 0000269|PubMed 16144831, ECO 0000269|PubMed 2155780, ECO 0000269|PubMed 23895467}. 
# Ensembl	ENST00000218075	ENSP00000218075; ENSG00000101958. [P23416-1]
# Ensembl	ENST00000355020	ENSP00000347123; ENSG00000101958. [P23416-2]
# Ensembl	ENST00000443437	ENSP00000387756; ENSG00000101958. [P23416-3]
# ExpressionAtlas	P23416	baseline and differential
# FUNCTION	GLRA2_HUMAN	Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed 2155780, PubMed 15302677, PubMed 16144831, PubMed 23895467, PubMed 25445488). Channel opening is also triggered by taurine and beta-alanine (PubMed 15302677). Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (PubMed 25445488). Plays a role in cellular responses to ethanol (PubMed 23895467). {ECO 0000269|PubMed 15302677, ECO 0000269|PubMed 16144831, ECO 0000269|PubMed 2155780, ECO 0000269|PubMed 23895467, ECO 0000269|PubMed 25445488}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0042995	cell projection; IEA:UniProtKB-SubCell.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0016594	glycine binding; IDA:UniProtKB.
# GO_function	GO:0016934	extracellular-glycine-gated chloride channel activity; IDA:UniProtKB.
# GO_function	GO:0022852	glycine-gated chloride ion channel activity; IDA:UniProtKB.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0007218	neuropeptide signaling pathway; IDA:UniProtKB.
# GO_process	GO:0034220	ion transmembrane transport; IDA:UniProtKB.
# GO_process	GO:0060012	synaptic transmission, glycinergic; IBA:GO_Central.
# GO_process	GO:0071230	cellular response to amino acid stimulus; IDA:UniProtKB.
# GO_process	GO:0071294	cellular response to zinc ion; IDA:UniProtKB.
# GO_process	GO:0071361	cellular response to ethanol; IDA:UniProtKB.
# GO_process	GO:1902476	chloride transmembrane transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.70.170.10	-; 1.
# Genevisible	P23416	HS
# HGNC	HGNC:4327	GLRA2
# IntAct	P23416	6
# InterPro	IPR006028	GABAA/Glycine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR008127	Glycine_rcpt_A
# InterPro	IPR008129	Glycine_rcpt_A2
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# MIM	305990	gene
# MISCELLANEOUS	The alpha subunit binds strychnine. {ECO:0000269|PubMed	2155780}. 
# Organism	GLRA2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR18945	PTHR18945
# PIR	S12381	S12381
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00253	GABAARECEPTR
# PRINTS	PR01673	GLYRALPHA
# PRINTS	PR01675	GLYRALPHA2
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-975298	Ligand-gated ion channel transport
# RecName	GLRA2_HUMAN	Glycine receptor subunit alpha-2
# RefSeq	NP_001112357	NM_001118885.1. [P23416-1]
# RefSeq	NP_001112358	NM_001118886.1. [P23416-2]
# RefSeq	NP_001165413	NM_001171942.1. [P23416-3]
# RefSeq	NP_002054	NM_002063.3. [P23416-1]
# RefSeq	XP_016884916	XM_017029427.1. [P23416-2]
# RefSeq	XP_016884917	XM_017029428.1. [P23416-3]
# RefSeq	XP_016884918	XM_017029429.1. [P23416-3]
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA2 sub- subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	GLRA2_HUMAN	Cell junction, synapse, postsynaptic cell membrane {ECO 0000250|UniProtKB Q7TNC8}; Multi-pass membrane protein {ECO 0000250|UniProtKB P23415}. Cell junction, synapse {ECO 0000250|UniProtKB Q7TNC8}. Cell membrane {ECO 0000269|PubMed 15302677, ECO 0000269|PubMed 16144831, ECO 0000269|PubMed 2155780, ECO 0000269|PubMed 23895467, ECO 0000269|PubMed 25445488}; Multi-pass membrane protein {ECO 0000250|UniProtKB P23415}. Cell projection {ECO 0000250|UniProtKB Q7TNC8}. 
# SUBUNIT	GLRA2_HUMAN	Homopentamer (in vitro). Interacts with GLRB (PubMed 16144831). Heteropentamer composed of GLRA2 and GLRB. Both homopentamers and heteropentamers form functional ion channels, but their characteristics are subtly different (PubMed 15302677). {ECO 0000269|PubMed 16144831, ECO 0000305|PubMed 15302677}. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TCDB	1.A.9.3	the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family
# TIGRFAMs	TIGR00860	LIC
# UCSC	uc004cwe	human. [P23416-1]
# eggNOG	ENOG410XPWH	LUCA
# eggNOG	KOG3643	Eukaryota
BLAST	swissprot:GLRA2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GLRA2_HUMAN
BioCyc	ZFISH:ENSG00000101958-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000101958-MONOMER
COXPRESdb	2742	http://coxpresdb.jp/data/gene/2742.shtml
CleanEx	HS_GLRA2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GLRA2
DOI	10.1002/(SICI)1096-8628(19980630)78:2<176::AID-AJMG16>3.0.CO	http://dx.doi.org/10.1002/(SICI)1096-8628(19980630)78:2<176::AID-AJMG16>3.0.CO
DOI	10.1016/j.neuropharm.2014.10.026	http://dx.doi.org/10.1016/j.neuropharm.2014.10.026
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.bjp.0705875	http://dx.doi.org/10.1038/sj.bjp.0705875
DOI	10.1074/jbc.M508303200	http://dx.doi.org/10.1074/jbc.M508303200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1101/gr.6.12.1200	http://dx.doi.org/10.1101/gr.6.12.1200
DOI	10.1111/acer.12192	http://dx.doi.org/10.1111/acer.12192
DrugBank	DB00145	http://www.drugbank.ca/drugs/DB00145
DrugBank	DB00431	http://www.drugbank.ca/drugs/DB00431
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
EMBL	AC003658	http://www.ebi.ac.uk/ena/data/view/AC003658
EMBL	AC003683	http://www.ebi.ac.uk/ena/data/view/AC003683
EMBL	AF053487	http://www.ebi.ac.uk/ena/data/view/AF053487
EMBL	AF053488	http://www.ebi.ac.uk/ena/data/view/AF053488
EMBL	AF053489	http://www.ebi.ac.uk/ena/data/view/AF053489
EMBL	AF053490	http://www.ebi.ac.uk/ena/data/view/AF053490
EMBL	AF053491	http://www.ebi.ac.uk/ena/data/view/AF053491
EMBL	AF053492	http://www.ebi.ac.uk/ena/data/view/AF053492
EMBL	AF053493	http://www.ebi.ac.uk/ena/data/view/AF053493
EMBL	AF053494	http://www.ebi.ac.uk/ena/data/view/AF053494
EMBL	AF053495	http://www.ebi.ac.uk/ena/data/view/AF053495
EMBL	AK289561	http://www.ebi.ac.uk/ena/data/view/AK289561
EMBL	AK297304	http://www.ebi.ac.uk/ena/data/view/AK297304
EMBL	AK312591	http://www.ebi.ac.uk/ena/data/view/AK312591
EMBL	AY437083	http://www.ebi.ac.uk/ena/data/view/AY437083
EMBL	AY437084	http://www.ebi.ac.uk/ena/data/view/AY437084
EMBL	BC032864	http://www.ebi.ac.uk/ena/data/view/BC032864
EMBL	CH471074	http://www.ebi.ac.uk/ena/data/view/CH471074
EMBL	CH471074	http://www.ebi.ac.uk/ena/data/view/CH471074
EMBL	CR450343	http://www.ebi.ac.uk/ena/data/view/CR450343
EMBL	U77724	http://www.ebi.ac.uk/ena/data/view/U77724
EMBL	U77724	http://www.ebi.ac.uk/ena/data/view/U77724
EMBL	U77725	http://www.ebi.ac.uk/ena/data/view/U77725
EMBL	U77725	http://www.ebi.ac.uk/ena/data/view/U77725
EMBL	U77726	http://www.ebi.ac.uk/ena/data/view/U77726
EMBL	U77726	http://www.ebi.ac.uk/ena/data/view/U77726
EMBL	U77727	http://www.ebi.ac.uk/ena/data/view/U77727
EMBL	U77727	http://www.ebi.ac.uk/ena/data/view/U77727
EMBL	U77728	http://www.ebi.ac.uk/ena/data/view/U77728
EMBL	U77728	http://www.ebi.ac.uk/ena/data/view/U77728
EMBL	U77729	http://www.ebi.ac.uk/ena/data/view/U77729
EMBL	U77729	http://www.ebi.ac.uk/ena/data/view/U77729
EMBL	U77730	http://www.ebi.ac.uk/ena/data/view/U77730
EMBL	U77730	http://www.ebi.ac.uk/ena/data/view/U77730
EMBL	U77731	http://www.ebi.ac.uk/ena/data/view/U77731
EMBL	U77731	http://www.ebi.ac.uk/ena/data/view/U77731
EMBL	X52008	http://www.ebi.ac.uk/ena/data/view/X52008
Ensembl	ENST00000218075	http://www.ensembl.org/id/ENST00000218075
Ensembl	ENST00000355020	http://www.ensembl.org/id/ENST00000355020
Ensembl	ENST00000443437	http://www.ensembl.org/id/ENST00000443437
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0042995	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042995
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0016594	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016594
GO_function	GO:0016934	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016934
GO_function	GO:0022852	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022852
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0007218	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007218
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0060012	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060012
GO_process	GO:0071230	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071230
GO_process	GO:0071294	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071294
GO_process	GO:0071361	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071361
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	GLRA2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GLRA2
GeneID	2742	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2742
GeneTree	ENSGT00760000118821	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118821
H-InvDB	HIX0016955	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0016955
HGNC	HGNC:4327	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4327
HOGENOM	HOG000231336	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231336&db=HOGENOM6
HOVERGEN	HBG051707	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051707&db=HOVERGEN
HPA	CAB070422	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB070422
InParanoid	P23416	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23416
IntAct	P23416	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23416*
InterPro	IPR006028	http://www.ebi.ac.uk/interpro/entry/IPR006028
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR008127	http://www.ebi.ac.uk/interpro/entry/IPR008127
InterPro	IPR008129	http://www.ebi.ac.uk/interpro/entry/IPR008129
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
Jabion	2742	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2742
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:2742	http://www.genome.jp/dbget-bin/www_bget?hsa:2742
KEGG_Orthology	KO:K05194	http://www.genome.jp/dbget-bin/www_bget?KO:K05194
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
MIM	305990	http://www.ncbi.nlm.nih.gov/omim/305990
MINT	MINT-1412636	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1412636
OMA	FREAFCK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FREAFCK
OrthoDB	EOG091G0805	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0805
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00253	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00253
PRINTS	PR01673	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01673
PRINTS	PR01675	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01675
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:GLRA2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GLRA2_HUMAN
PSORT-B	swissprot:GLRA2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GLRA2_HUMAN
PSORT2	swissprot:GLRA2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GLRA2_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA28728	http://www.pharmgkb.org/do/serve?objId=PA28728&objCls=Gene
Phobius	swissprot:GLRA2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GLRA2_HUMAN
PhylomeDB	P23416	http://phylomedb.org/?seqid=P23416
ProteinModelPortal	P23416	http://www.proteinmodelportal.org/query/uniprot/P23416
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15302677	http://www.ncbi.nlm.nih.gov/pubmed/15302677
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	16144831	http://www.ncbi.nlm.nih.gov/pubmed/16144831
PubMed	2155780	http://www.ncbi.nlm.nih.gov/pubmed/2155780
PubMed	23895467	http://www.ncbi.nlm.nih.gov/pubmed/23895467
PubMed	25445488	http://www.ncbi.nlm.nih.gov/pubmed/25445488
PubMed	8973915	http://www.ncbi.nlm.nih.gov/pubmed/8973915
PubMed	9674912	http://www.ncbi.nlm.nih.gov/pubmed/9674912
Reactome	R-HSA-975298	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-975298
RefSeq	NP_001112357	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001112357
RefSeq	NP_001112358	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001112358
RefSeq	NP_001165413	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001165413
RefSeq	NP_002054	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002054
RefSeq	XP_016884916	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016884916
RefSeq	XP_016884917	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016884917
RefSeq	XP_016884918	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016884918
SMR	P23416	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23416
STRING	9606.ENSP00000218075	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000218075&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TCDB	1.A.9.3	http://www.tcdb.org/search/result.php?tc=1.A.9.3
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc004cwe	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004cwe&org=rat
UniGene	Hs.2700	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.2700
UniProtKB	GLRA2_HUMAN	http://www.uniprot.org/uniprot/GLRA2_HUMAN
UniProtKB-AC	P23416	http://www.uniprot.org/uniprot/P23416
charge	swissprot:GLRA2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GLRA2_HUMAN
eggNOG	ENOG410XPWH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPWH
eggNOG	KOG3643	http://eggnogapi.embl.de/nog_data/html/tree/KOG3643
epestfind	swissprot:GLRA2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GLRA2_HUMAN
garnier	swissprot:GLRA2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GLRA2_HUMAN
helixturnhelix	swissprot:GLRA2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLRA2_HUMAN
hmoment	swissprot:GLRA2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GLRA2_HUMAN
iep	swissprot:GLRA2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GLRA2_HUMAN
inforesidue	swissprot:GLRA2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GLRA2_HUMAN
neXtProt	NX_P23416	http://www.nextprot.org/db/entry/NX_P23416
octanol	swissprot:GLRA2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GLRA2_HUMAN
pepcoil	swissprot:GLRA2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GLRA2_HUMAN
pepdigest	swissprot:GLRA2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GLRA2_HUMAN
pepinfo	swissprot:GLRA2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GLRA2_HUMAN
pepnet	swissprot:GLRA2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GLRA2_HUMAN
pepstats	swissprot:GLRA2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GLRA2_HUMAN
pepwheel	swissprot:GLRA2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GLRA2_HUMAN
pepwindow	swissprot:GLRA2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GLRA2_HUMAN
sigcleave	swissprot:GLRA2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GLRA2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S6A11_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P48066-1; Sequence=Displayed; Name=2; IsoId=P48066-2; Sequence=VSP_056539; Note=No experimental confirmation available.; 
# AltName	S6A11_HUMAN	Solute carrier family 6 member 11
# CCDS	CCDS2602	-. [P48066-1]
# CCDS	CCDS82734	-. [P48066-2]
# DrugBank	DB00349	Clobazam
# Ensembl	ENST00000254488	ENSP00000254488; ENSG00000132164. [P48066-1]
# Ensembl	ENST00000454147	ENSP00000404120; ENSG00000132164. [P48066-2]
# FUNCTION	S6A11_HUMAN	Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. 
# GO_component	GO:0005737	cytoplasm; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_component	GO:0043005	neuron projection; IBA:GO_Central.
# GO_function	GO:0042165	neurotransmitter binding; IEA:Ensembl.
# GO_function	S6A11_HUMAN	GO 0005328 neurotransmitter sodium symporter activity; IEA InterPro.
# GO_function	S6A11_HUMAN	GO 0005332 gamma-aminobutyric acid sodium symporter activity; IBA GO_Central.
# GO_process	GO:0006836	neurotransmitter transport; IBA:GO_Central.
# GO_process	GO:0007268	chemical synaptic transmission; IBA:GO_Central.
# GO_process	GO:0007420	brain development; IEA:Ensembl.
# GO_process	GO:0015812	gamma-aminobutyric acid transport; IBA:GO_Central.
# GO_process	GO:0042493	response to drug; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# Genevisible	P48066	HS
# HGNC	HGNC:11044	SLC6A11
# InterPro	IPR000175	Na/ntran_symport
# InterPro	IPR002982	Na/ntran_symport_GABA_GAT3
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Brite	ko04040	 Ion channels
# MIM	607952	gene
# Organism	S6A11_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11616	PTHR11616
# PRINTS	PR00176	NANEUSMPORT
# PRINTS	PR01197	GAT3TRNSPORT
# PROSITE	PS00610	NA_NEUROTRAN_SYMP_1
# PROSITE	PS00754	NA_NEUROTRAN_SYMP_2
# PROSITE	PS50267	NA_NEUROTRAN_SYMP_3
# Pfam	PF00209	SNF
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-442660	Na+/Cl- dependent neurotransmitter transporters
# Reactome	R-HSA-71288	Creatine metabolism
# Reactome	R-HSA-888593	Reuptake of GABA
# RecName	S6A11_HUMAN	Sodium- and chloride-dependent GABA transporter 3
# RefSeq	NP_001304335	NM_001317406.1. [P48066-2]
# RefSeq	NP_055044	NM_014229.2. [P48066-1]
# SIMILARITY	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A11 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	S6A11_HUMAN	Membrane; Multi-pass membrane protein. 
# TCDB	2.A.22.3:the neurotransmitter	sodium symporter (nss) family
# TISSUE SPECIFICITY	S6A11_HUMAN	Widespread distribution in the brain. 
# UCSC	uc003bvy	human. [P48066-1]
# eggNOG	COG0733	LUCA
# eggNOG	KOG3659	Eukaryota
BLAST	swissprot:S6A11_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S6A11_HUMAN
BioCyc	ZFISH:ENSG00000132164-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000132164-MONOMER
COXPRESdb	6538	http://coxpresdb.jp/data/gene/6538.shtml
CleanEx	HS_SLC6A11	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC6A11
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00349	http://www.drugbank.ca/drugs/DB00349
EMBL	AC018495	http://www.ebi.ac.uk/ena/data/view/AC018495
EMBL	AC027128	http://www.ebi.ac.uk/ena/data/view/AC027128
EMBL	AK312719	http://www.ebi.ac.uk/ena/data/view/AK312719
EMBL	BC036083	http://www.ebi.ac.uk/ena/data/view/BC036083
EMBL	CH471055	http://www.ebi.ac.uk/ena/data/view/CH471055
EMBL	S75989	http://www.ebi.ac.uk/ena/data/view/S75989
Ensembl	ENST00000254488	http://www.ensembl.org/id/ENST00000254488
Ensembl	ENST00000454147	http://www.ensembl.org/id/ENST00000454147
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0043005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043005
GO_function	GO:0005328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005328
GO_function	GO:0005332	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005332
GO_function	GO:0042165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042165
GO_process	GO:0006836	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006836
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007420	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007420
GO_process	GO:0015812	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015812
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GeneCards	SLC6A11	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC6A11
GeneID	6538	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6538
GeneTree	ENSGT00760000118857	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118857
HGNC	HGNC:11044	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11044
HOGENOM	HOG000116406	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116406&db=HOGENOM6
HOVERGEN	HBG071421	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG071421&db=HOVERGEN
HPA	HPA037981	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA037981
InParanoid	P48066	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P48066
InterPro	IPR000175	http://www.ebi.ac.uk/interpro/entry/IPR000175
InterPro	IPR002982	http://www.ebi.ac.uk/interpro/entry/IPR002982
Jabion	6538	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6538
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:6538	http://www.genome.jp/dbget-bin/www_bget?hsa:6538
KEGG_Orthology	KO:K05039	http://www.genome.jp/dbget-bin/www_bget?KO:K05039
MIM	607952	http://www.ncbi.nlm.nih.gov/omim/607952
OMA	YRPPSLI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YRPPSLI
OrthoDB	EOG091G08PX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08PX
PANTHER	PTHR11616	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11616
PRINTS	PR00176	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00176
PRINTS	PR01197	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01197
PROSITE	PS00610	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00610
PROSITE	PS00754	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00754
PROSITE	PS50267	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50267
PSORT	swissprot:S6A11_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S6A11_HUMAN
PSORT-B	swissprot:S6A11_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S6A11_HUMAN
PSORT2	swissprot:S6A11_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S6A11_HUMAN
Pfam	PF00209	http://pfam.xfam.org/family/PF00209
PharmGKB	PA35907	http://www.pharmgkb.org/do/serve?objId=PA35907&objCls=Gene
Phobius	swissprot:S6A11_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S6A11_HUMAN
PhylomeDB	P48066	http://phylomedb.org/?seqid=P48066
ProteinModelPortal	P48066	http://www.proteinmodelportal.org/query/uniprot/P48066
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	7874447	http://www.ncbi.nlm.nih.gov/pubmed/7874447
Reactome	R-HSA-442660	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442660
Reactome	R-HSA-71288	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-71288
Reactome	R-HSA-888593	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-888593
RefSeq	NP_001304335	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001304335
RefSeq	NP_055044	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055044
STRING	9606.ENSP00000254488	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000254488&targetmode=cogs
TCDB	2.A.22.3	http://www.tcdb.org/search/result.php?tc=2.A.22.3
UCSC	uc003bvy	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003bvy&org=rat
UniGene	Hs.655078	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.655078
UniGene	Hs.657405	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.657405
UniProtKB	S6A11_HUMAN	http://www.uniprot.org/uniprot/S6A11_HUMAN
UniProtKB-AC	P48066	http://www.uniprot.org/uniprot/P48066
charge	swissprot:S6A11_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S6A11_HUMAN
eggNOG	COG0733	http://eggnogapi.embl.de/nog_data/html/tree/COG0733
eggNOG	KOG3659	http://eggnogapi.embl.de/nog_data/html/tree/KOG3659
epestfind	swissprot:S6A11_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S6A11_HUMAN
garnier	swissprot:S6A11_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S6A11_HUMAN
helixturnhelix	swissprot:S6A11_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S6A11_HUMAN
hmoment	swissprot:S6A11_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S6A11_HUMAN
iep	swissprot:S6A11_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S6A11_HUMAN
inforesidue	swissprot:S6A11_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S6A11_HUMAN
neXtProt	NX_P48066	http://www.nextprot.org/db/entry/NX_P48066
octanol	swissprot:S6A11_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S6A11_HUMAN
pepcoil	swissprot:S6A11_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S6A11_HUMAN
pepdigest	swissprot:S6A11_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S6A11_HUMAN
pepinfo	swissprot:S6A11_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S6A11_HUMAN
pepnet	swissprot:S6A11_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S6A11_HUMAN
pepstats	swissprot:S6A11_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S6A11_HUMAN
pepwheel	swissprot:S6A11_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S6A11_HUMAN
pepwindow	swissprot:S6A11_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S6A11_HUMAN
sigcleave	swissprot:S6A11_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S6A11_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GTR11_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=GLUT11; IsoId=Q9BYW1-1; Sequence=Displayed; Name=2; Synonyms=GLUT11-s; IsoId=Q9BYW1-2; Sequence=VSP_006293, VSP_006294, VSP_006295; Name=3; IsoId=Q9BYW1-3; Sequence=VSP_006293; Name=4; Synonyms=GLUT11-L; IsoId=Q9BYW1-4; Sequence=VSP_045650; 
# AltName	GTR11_HUMAN	Glucose transporter type 10
# AltName	GTR11_HUMAN	Glucose transporter type 11
# CAUTION	Has been described as GLUT10 in literature, but this gene name has already been used for SLC2A10. {ECO	0000305}.
# CCDS	CCDS13818	-. [Q9BYW1-4]
# CCDS	CCDS33616	-. [Q9BYW1-3]
# CCDS	CCDS46673	-. [Q9BYW1-1]
# CDD	cd06174	MFS
# ChiTaRS	SLC2A11	human
# Ensembl	ENST00000316185	ENSP00000326748; ENSG00000133460. [Q9BYW1-3]
# Ensembl	ENST00000345044	ENSP00000342542; ENSG00000133460. [Q9BYW1-1]
# Ensembl	ENST00000398356	ENSP00000381399; ENSG00000133460. [Q9BYW1-4]
# Ensembl	ENST00000618502	ENSP00000482495; ENSG00000275744. [Q9BYW1-1]
# Ensembl	ENST00000619254	ENSP00000480839; ENSG00000275744. [Q9BYW1-4]
# Ensembl	ENST00000620942	ENSP00000483163; ENSG00000275744. [Q9BYW1-3]
# ExpressionAtlas	Q9BYW1	baseline and differential
# FUNCTION	GTR11_HUMAN	Facilitative glucose transporter. {ECO 0000269|PubMed 12175779}. 
# GO_component	GO:0005634	nucleus; IDA:HPA.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0030054	cell junction; IDA:HPA.
# GO_function	GO:0051119	sugar transmembrane transporter activity; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# Genevisible	Q9BYW1	HS
# HGNC	HGNC:14239	SLC2A11
# InterPro	IPR003663	Sugar/inositol_transpt
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR005829	Sugar_transporter_CS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	610367	gene
# Organism	GTR11_HUMAN	Homo sapiens (Human)
# PRINTS	PR00171	SUGRTRNSPORT
# PROSITE	PS00217	SUGAR_TRANSPORT_2
# PROSITE	PS50850	MFS
# Pfam	PF00083	Sugar_tr
# Proteomes	UP000005640	Chromosome 22
# Reactome	R-HSA-428776	Class II GLUTs
# RecName	GTR11_HUMAN	Solute carrier family 2, facilitated glucose transporter member 11
# RefSeq	NP_001020109	NM_001024938.3. [Q9BYW1-1]
# RefSeq	NP_001020110	NM_001024939.3. [Q9BYW1-3]
# RefSeq	NP_110434	NM_030807.4. [Q9BYW1-4]
# SIMILARITY	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	GTR11_HUMAN	Cell membrane {ECO 0000269|PubMed 12175779}; Multi-pass membrane protein {ECO 0000269|PubMed 12175779}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.1.44	the major facilitator superfamily (mfs)
# TIGRFAMs	TIGR00879	SP
# TISSUE SPECIFICITY	GTR11_HUMAN	Expressed in heart and skeletal muscle. 
# UCSC	uc002zym	human. [Q9BYW1-1]
# eggNOG	COG0477	LUCA
# eggNOG	KOG0569	Eukaryota
BLAST	swissprot:GTR11_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GTR11_HUMAN
BioCyc	ZFISH:ENSG00000133460-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000133460-MONOMER
COXPRESdb	66035	http://coxpresdb.jp/data/gene/66035.shtml
CleanEx	HS_SLC2A11	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC2A11
DOI	10.1006/bbrc.2001.6101	http://dx.doi.org/10.1006/bbrc.2001.6101
DOI	10.1016/S1096-7192(02)00018-5	http://dx.doi.org/10.1016/S1096-7192(02)00018-5
DOI	10.1038/990031	http://dx.doi.org/10.1038/990031
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/dnares/12.2.117	http://dx.doi.org/10.1093/dnares/12.2.117
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/gb-2004-5-10-r84	http://dx.doi.org/10.1186/gb-2004-5-10-r84
EMBL	AB049214	http://www.ebi.ac.uk/ena/data/view/AB049214
EMBL	AB067443	http://www.ebi.ac.uk/ena/data/view/AB067443
EMBL	AF443201	http://www.ebi.ac.uk/ena/data/view/AF443201
EMBL	AJ271290	http://www.ebi.ac.uk/ena/data/view/AJ271290
EMBL	AK075467	http://www.ebi.ac.uk/ena/data/view/AK075467
EMBL	AK314502	http://www.ebi.ac.uk/ena/data/view/AK314502
EMBL	AP000350	http://www.ebi.ac.uk/ena/data/view/AP000350
EMBL	BC100808	http://www.ebi.ac.uk/ena/data/view/BC100808
EMBL	CH471095	http://www.ebi.ac.uk/ena/data/view/CH471095
EMBL	CR456373	http://www.ebi.ac.uk/ena/data/view/CR456373
Ensembl	ENST00000316185	http://www.ensembl.org/id/ENST00000316185
Ensembl	ENST00000345044	http://www.ensembl.org/id/ENST00000345044
Ensembl	ENST00000398356	http://www.ensembl.org/id/ENST00000398356
Ensembl	ENST00000618502	http://www.ensembl.org/id/ENST00000618502
Ensembl	ENST00000619254	http://www.ensembl.org/id/ENST00000619254
Ensembl	ENST00000620942	http://www.ensembl.org/id/ENST00000620942
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_function	GO:0051119	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051119
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GeneCards	SLC2A11	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC2A11
GeneID	66035	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=66035
GeneTree	ENSGT00760000119022	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119022
HGNC	HGNC:14239	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14239
HOGENOM	HOG000202871	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202871&db=HOGENOM6
HOVERGEN	HBG014816	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG014816&db=HOVERGEN
HPA	HPA042960	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042960
HPA	HPA071184	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA071184
InParanoid	Q9BYW1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9BYW1
InterPro	IPR003663	http://www.ebi.ac.uk/interpro/entry/IPR003663
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR005829	http://www.ebi.ac.uk/interpro/entry/IPR005829
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	66035	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=66035
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:66035	http://www.genome.jp/dbget-bin/www_bget?hsa:66035
KEGG_Orthology	KO:K08148	http://www.genome.jp/dbget-bin/www_bget?KO:K08148
MIM	610367	http://www.ncbi.nlm.nih.gov/omim/610367
PRINTS	PR00171	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00171
PROSITE	PS00217	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00217
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:GTR11_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GTR11_HUMAN
PSORT-B	swissprot:GTR11_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GTR11_HUMAN
PSORT2	swissprot:GTR11_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GTR11_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
PharmGKB	PA37861	http://www.pharmgkb.org/do/serve?objId=PA37861&objCls=Gene
Phobius	swissprot:GTR11_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GTR11_HUMAN
PhylomeDB	Q9BYW1	http://phylomedb.org/?seqid=Q9BYW1
ProteinModelPortal	Q9BYW1	http://www.proteinmodelportal.org/query/uniprot/Q9BYW1
PubMed	10591208	http://www.ncbi.nlm.nih.gov/pubmed/10591208
PubMed	11741323	http://www.ncbi.nlm.nih.gov/pubmed/11741323
PubMed	12175779	http://www.ncbi.nlm.nih.gov/pubmed/12175779
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15461802	http://www.ncbi.nlm.nih.gov/pubmed/15461802
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16303743	http://www.ncbi.nlm.nih.gov/pubmed/16303743
Reactome	R-HSA-428776	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428776
RefSeq	NP_001020109	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001020109
RefSeq	NP_001020110	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001020110
RefSeq	NP_110434	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_110434
STRING	9606.ENSP00000381399	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000381399&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.1.44	http://www.tcdb.org/search/result.php?tc=2.A.1.1.44
TIGRFAMs	TIGR00879	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00879
UCSC	uc002zym	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002zym&org=rat
UniGene	Hs.661910	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.661910
UniGene	Hs.743282	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.743282
UniProtKB	GTR11_HUMAN	http://www.uniprot.org/uniprot/GTR11_HUMAN
UniProtKB-AC	Q9BYW1	http://www.uniprot.org/uniprot/Q9BYW1
charge	swissprot:GTR11_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GTR11_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG0569	http://eggnogapi.embl.de/nog_data/html/tree/KOG0569
epestfind	swissprot:GTR11_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GTR11_HUMAN
garnier	swissprot:GTR11_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GTR11_HUMAN
helixturnhelix	swissprot:GTR11_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GTR11_HUMAN
hmoment	swissprot:GTR11_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GTR11_HUMAN
iep	swissprot:GTR11_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GTR11_HUMAN
inforesidue	swissprot:GTR11_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GTR11_HUMAN
neXtProt	NX_Q9BYW1	http://www.nextprot.org/db/entry/NX_Q9BYW1
octanol	swissprot:GTR11_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GTR11_HUMAN
pepcoil	swissprot:GTR11_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GTR11_HUMAN
pepdigest	swissprot:GTR11_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GTR11_HUMAN
pepinfo	swissprot:GTR11_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GTR11_HUMAN
pepnet	swissprot:GTR11_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GTR11_HUMAN
pepstats	swissprot:GTR11_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GTR11_HUMAN
pepwheel	swissprot:GTR11_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GTR11_HUMAN
pepwindow	swissprot:GTR11_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GTR11_HUMAN
sigcleave	swissprot:GTR11_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GTR11_HUMAN
## Database	ID	URL or Descriptions
# AltName	AT1B2_HUMAN	Adhesion molecule in glia
# AltName	AT1B2_HUMAN	Sodium/potassium-dependent ATPase subunit beta-2
# BioGrid	106972	8
# ChiTaRS	ATP1B2	human
# DOMAIN	AT1B2_HUMAN	The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties. {ECO 0000250}. 
# Ensembl	ENST00000250111	ENSP00000250111; ENSG00000129244
# ExpressionAtlas	P14415	baseline and differential
# FUNCTION	AT1B2_HUMAN	Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth. {ECO 0000250}. 
# FUNCTION	AT1B2_HUMAN	This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known. 
# GO_component	AT1B2_HUMAN	GO 0005890 sodium potassium-exchanging ATPase complex; IDA BHF-UCL.
# GO_component	GO:0005737	cytoplasm; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016324	apical plasma membrane; IEA:Ensembl.
# GO_function	AT1B2_HUMAN	GO 0005391 sodium potassium-exchanging ATPase activity; IDA BHF-UCL.
# GO_function	GO:0001671	ATPase activator activity; IDA:BHF-UCL.
# GO_function	GO:0051117	ATPase binding; IPI:BHF-UCL.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006883	cellular sodium ion homeostasis; IDA:BHF-UCL.
# GO_process	GO:0007155	cell adhesion; IEA:UniProtKB-KW.
# GO_process	GO:0010107	potassium ion import; IDA:BHF-UCL.
# GO_process	GO:0030007	cellular potassium ion homeostasis; IDA:BHF-UCL.
# GO_process	GO:0032781	positive regulation of ATPase activity; IDA:BHF-UCL.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0036376	sodium ion export from cell; IDA:BHF-UCL.
# GO_process	GO:0050821	protein stabilization; IDA:BHF-UCL.
# GO_process	GO:0050900	leukocyte migration; TAS:Reactome.
# GO_process	GO:0086009	membrane repolarization; IDA:BHF-UCL.
# GO_process	GO:0086064	cell communication by electrical coupling involved in cardiac conduction; TAS:BHF-UCL.
# GO_process	GO:1901018	positive regulation of potassium ion transmembrane transporter activity; IDA:BHF-UCL.
# GO_process	GO:1903278	positive regulation of sodium ion export from cell; IDA:BHF-UCL.
# GO_process	GO:1903288	positive regulation of potassium ion import; IDA:BHF-UCL.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0030234	enzyme regulator activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007155	cell adhesion
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048870	cell motility
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P14415	HS
# HGNC	HGNC:805	ATP1B2
# InterPro	IPR000402	Na/K_ATPase_sub_beta
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04090	 Cellular antigens
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko04960	Aldosterone-regulated sodium reabsorption
# KEGG_Pathway	ko04961	Endocrine and other factor-regulated calcium reabsorption
# KEGG_Pathway	ko04964	Proximal tubule bicarbonate reclamation
# KEGG_Pathway	ko04970	Salivary secretion
# KEGG_Pathway	ko04971	Gastric acid secretion
# KEGG_Pathway	ko04972	Pancreatic secretion
# KEGG_Pathway	ko04973	Carbohydrate digestion and absorption
# KEGG_Pathway	ko04974	Protein digestion and absorption
# KEGG_Pathway	ko04976	Bile secretion
# KEGG_Pathway	ko04978	Mineral absorption
# MIM	182331	gene
# Organism	AT1B2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11523	PTHR11523
# PIR	B32459	B32459
# PIR	JC5107	JC5107
# PROSITE	PS00390	ATPASE_NA_K_BETA_1
# PROSITE	PS00391	ATPASE_NA_K_BETA_2
# Pfam	PF00287	Na_K-ATPase
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-210991	Basigin interactions
# Reactome	R-HSA-5578775	Ion homeostasis
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	AT1B2_HUMAN	Sodium/potassium-transporting ATPase subunit beta-2
# RefSeq	NP_001290192	NM_001303263.1
# RefSeq	NP_001669	NM_001678.4
# SIMILARITY	Belongs to the X(+)/potassium ATPases subunit beta family. {ECO	0000305}.
# SUBCELLULAR LOCATION	AT1B2_HUMAN	Cell membrane; Single-pass type II membrane protein. 
# SUBUNIT	Composed of three subunits	 alpha (catalytic), beta and gamma. 
# TIGRFAMs	TIGR01107	Na_K_ATPase_bet
# UCSC	uc002gif	human
# eggNOG	ENOG411150A	LUCA
# eggNOG	KOG3927	Eukaryota
BLAST	swissprot:AT1B2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AT1B2_HUMAN
BioCyc	ZFISH:HS05260-MONOMER	http://biocyc.org/getid?id=ZFISH:HS05260-MONOMER
COXPRESdb	482	http://coxpresdb.jp/data/gene/482.shtml
CleanEx	HS_ATP1B2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP1B2
DOI	10.1016/0005-2736(94)90287-9	http://dx.doi.org/10.1016/0005-2736(94)90287-9
DOI	10.1016/0378-1119(96)00258-2	http://dx.doi.org/10.1016/0378-1119(96)00258-2
DOI	10.1016/S0378-1119(97)00661-6	http://dx.doi.org/10.1016/S0378-1119(97)00661-6
DOI	10.1021/bi900868e	http://dx.doi.org/10.1021/bi900868e
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF007876	http://www.ebi.ac.uk/ena/data/view/AF007876
EMBL	AK290143	http://www.ebi.ac.uk/ena/data/view/AK290143
EMBL	BC126175	http://www.ebi.ac.uk/ena/data/view/BC126175
EMBL	CH471108	http://www.ebi.ac.uk/ena/data/view/CH471108
EMBL	M81181	http://www.ebi.ac.uk/ena/data/view/M81181
EMBL	U45945	http://www.ebi.ac.uk/ena/data/view/U45945
Ensembl	ENST00000250111	http://www.ensembl.org/id/ENST00000250111
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005890
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_function	GO:0001671	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001671
GO_function	GO:0005391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005391
GO_function	GO:0051117	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051117
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006883	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006883
GO_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GO_process	GO:0010107	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010107
GO_process	GO:0030007	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030007
GO_process	GO:0032781	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032781
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0036376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036376
GO_process	GO:0050821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050821
GO_process	GO:0050900	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050900
GO_process	GO:0086009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086009
GO_process	GO:0086064	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086064
GO_process	GO:1901018	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901018
GO_process	GO:1903278	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903278
GO_process	GO:1903288	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903288
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0030234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ATP1B2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP1B2
GeneID	482	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=482
GeneTree	ENSGT00550000074530	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074530
HGNC	HGNC:805	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:805
HOGENOM	HOG000039248	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000039248&db=HOGENOM6
HOVERGEN	HBG050603	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050603&db=HOVERGEN
HPA	HPA010698	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA010698
InParanoid	P14415	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P14415
IntAct	P14415	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P14415*
InterPro	IPR000402	http://www.ebi.ac.uk/interpro/entry/IPR000402
Jabion	482	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=482
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04090	http://www.genome.jp/dbget-bin/www_bget?ko04090
KEGG_Gene	hsa:482	http://www.genome.jp/dbget-bin/www_bget?hsa:482
KEGG_Orthology	KO:K01540	http://www.genome.jp/dbget-bin/www_bget?KO:K01540
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko04960	http://www.genome.jp/kegg-bin/show_pathway?ko04960
KEGG_Pathway	ko04961	http://www.genome.jp/kegg-bin/show_pathway?ko04961
KEGG_Pathway	ko04964	http://www.genome.jp/kegg-bin/show_pathway?ko04964
KEGG_Pathway	ko04970	http://www.genome.jp/kegg-bin/show_pathway?ko04970
KEGG_Pathway	ko04971	http://www.genome.jp/kegg-bin/show_pathway?ko04971
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
KEGG_Pathway	ko04973	http://www.genome.jp/kegg-bin/show_pathway?ko04973
KEGG_Pathway	ko04974	http://www.genome.jp/kegg-bin/show_pathway?ko04974
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
KEGG_Pathway	ko04978	http://www.genome.jp/kegg-bin/show_pathway?ko04978
MIM	182331	http://www.ncbi.nlm.nih.gov/omim/182331
OMA	TESWDLY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TESWDLY
OrthoDB	EOG091G0DJ4	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0DJ4
PANTHER	PTHR11523	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11523
PROSITE	PS00390	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00390
PROSITE	PS00391	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00391
PSORT	swissprot:AT1B2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AT1B2_HUMAN
PSORT-B	swissprot:AT1B2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AT1B2_HUMAN
PSORT2	swissprot:AT1B2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AT1B2_HUMAN
Pfam	PF00287	http://pfam.xfam.org/family/PF00287
PharmGKB	PA67	http://www.pharmgkb.org/do/serve?objId=PA67&objCls=Gene
Phobius	swissprot:AT1B2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AT1B2_HUMAN
PhylomeDB	P14415	http://phylomedb.org/?seqid=P14415
ProteinModelPortal	P14415	http://www.proteinmodelportal.org/query/uniprot/P14415
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	19694409	http://www.ncbi.nlm.nih.gov/pubmed/19694409
PubMed	2538450	http://www.ncbi.nlm.nih.gov/pubmed/2538450
PubMed	8305453	http://www.ncbi.nlm.nih.gov/pubmed/8305453
PubMed	8918259	http://www.ncbi.nlm.nih.gov/pubmed/8918259
PubMed	9524271	http://www.ncbi.nlm.nih.gov/pubmed/9524271
Reactome	R-HSA-210991	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-210991
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_001290192	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001290192
RefSeq	NP_001669	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001669
STRING	9606.ENSP00000250111	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000250111&targetmode=cogs
TIGRFAMs	TIGR01107	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01107
UCSC	uc002gif	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002gif&org=rat
UniGene	Hs.643540	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.643540
UniProtKB	AT1B2_HUMAN	http://www.uniprot.org/uniprot/AT1B2_HUMAN
UniProtKB-AC	P14415	http://www.uniprot.org/uniprot/P14415
charge	swissprot:AT1B2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AT1B2_HUMAN
eggNOG	ENOG411150A	http://eggnogapi.embl.de/nog_data/html/tree/ENOG411150A
eggNOG	KOG3927	http://eggnogapi.embl.de/nog_data/html/tree/KOG3927
epestfind	swissprot:AT1B2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AT1B2_HUMAN
garnier	swissprot:AT1B2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AT1B2_HUMAN
helixturnhelix	swissprot:AT1B2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AT1B2_HUMAN
hmoment	swissprot:AT1B2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AT1B2_HUMAN
iep	swissprot:AT1B2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AT1B2_HUMAN
inforesidue	swissprot:AT1B2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AT1B2_HUMAN
neXtProt	NX_P14415	http://www.nextprot.org/db/entry/NX_P14415
octanol	swissprot:AT1B2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AT1B2_HUMAN
pepcoil	swissprot:AT1B2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AT1B2_HUMAN
pepdigest	swissprot:AT1B2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AT1B2_HUMAN
pepinfo	swissprot:AT1B2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AT1B2_HUMAN
pepnet	swissprot:AT1B2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AT1B2_HUMAN
pepstats	swissprot:AT1B2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AT1B2_HUMAN
pepwheel	swissprot:AT1B2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AT1B2_HUMAN
pepwindow	swissprot:AT1B2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AT1B2_HUMAN
sigcleave	swissprot:AT1B2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AT1B2_HUMAN
## Database	ID	URL or Descriptions
# AltName	VATD_HUMAN	V-ATPase 28 kDa accessory protein
# AltName	VATD_HUMAN	Vacuolar proton pump subunit D
# BioGrid	119513	51
# ChiTaRS	ATP6V1D	human
# Ensembl	ENST00000216442	ENSP00000216442; ENSG00000100554
# Ensembl	ENST00000554087	ENSP00000451167; ENSG00000100554
# ExpressionAtlas	Q9Y5K8	baseline and differential
# FUNCTION	VATD_HUMAN	Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. {ECO 0000250, ECO 0000269|PubMed 21844891}. 
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0033176	proton-transporting V-type ATPase complex; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro.
# GO_process	GO:0008286	insulin receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0015992	proton transport; IEA:UniProtKB-KW.
# GO_process	GO:0016241	regulation of macroautophagy; NAS:ParkinsonsUK-UCL.
# GO_process	GO:0033572	transferrin transport; TAS:Reactome.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0042384	cilium assembly; IMP:UniProtKB.
# GO_process	GO:0061512	protein localization to cilium; IMP:UniProtKB.
# GO_process	GO:0090383	phagosome acidification; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9Y5K8	HS
# HGNC	HGNC:13527	ATP6V1D
# INTERACTION	VATD_HUMAN	Q8N1B4 VPS52; NbExp=5; IntAct=EBI-2684998, EBI-2799833; 
# IntAct	Q9Y5K8	15
# InterPro	IPR002699	V_ATPase_D
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04966	Collecting duct acid secretion
# KEGG_Pathway	ko05110	Vibrio cholerae infection
# KEGG_Pathway	ko05120	Epithelial cell signaling in Helicobacter pylori infection
# KEGG_Pathway	ko05323	Rheumatoid arthritis
# MIM	609398	gene
# Organism	VATD_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11671	PTHR11671
# Pfam	PF01813	ATP-synt_D
# Proteomes	UP000005640	Chromosome 14
# Reactome	R-HSA-1222556	ROS, RNS production in response to bacteria
# Reactome	R-HSA-6798695	Neutrophil degranulation
# Reactome	R-HSA-77387	Insulin receptor recycling
# Reactome	R-HSA-917977	Transferrin endocytosis and recycling
# Reactome	R-HSA-983712	Ion channel transport
# RecName	VATD_HUMAN	V-type proton ATPase subunit D
# RefSeq	NP_057078	NM_015994.3
# SIMILARITY	Belongs to the V-ATPase D subunit family. {ECO	0000305}.
# SUBCELLULAR LOCATION	VATD_HUMAN	Membrane {ECO 0000305|PubMed 21844891}; Peripheral membrane protein {ECO 0000305|PubMed 21844891}; Cytoplasmic side {ECO 0000305|PubMed 21844891}. Note=Localizes to centrosome and the base of the cilium. 
# SUBUNIT	V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d). Interacts with SNX10; may play a role in ciliogenesis. {ECO	0000269|PubMed:21844891}. 
# TIGRFAMs	TIGR00309	V_ATPase_subD
# UCSC	uc001xjf	human
# eggNOG	COG1394	LUCA
# eggNOG	KOG1647	Eukaryota
BLAST	swissprot:VATD_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VATD_HUMAN
BioCyc	MetaCyc:HS02107-MONOMER	http://biocyc.org/getid?id=MetaCyc:HS02107-MONOMER
BioCyc	ZFISH:HS02107-MONOMER	http://biocyc.org/getid?id=ZFISH:HS02107-MONOMER
COG	COG1394	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1394
COXPRESdb	51382	http://coxpresdb.jp/data/gene/51382.shtml
CleanEx	HS_ATP6V1D	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP6V1D
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1038/cr.2011.134	http://dx.doi.org/10.1038/cr.2011.134
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.160270997	http://dx.doi.org/10.1073/pnas.160270997
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF100741	http://www.ebi.ac.uk/ena/data/view/AF100741
EMBL	AF104629	http://www.ebi.ac.uk/ena/data/view/AF104629
EMBL	AF145316	http://www.ebi.ac.uk/ena/data/view/AF145316
EMBL	AK315784	http://www.ebi.ac.uk/ena/data/view/AK315784
EMBL	BC001411	http://www.ebi.ac.uk/ena/data/view/BC001411
EMBL	CH471061	http://www.ebi.ac.uk/ena/data/view/CH471061
Ensembl	ENST00000216442	http://www.ensembl.org/id/ENST00000216442
Ensembl	ENST00000554087	http://www.ensembl.org/id/ENST00000554087
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0033176	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033176
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GO_process	GO:0008286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008286
GO_process	GO:0015992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992
GO_process	GO:0016241	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016241
GO_process	GO:0033572	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033572
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0042384	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042384
GO_process	GO:0061512	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061512
GO_process	GO:0090383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090383
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ATP6V1D	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP6V1D
GeneID	51382	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51382
GeneTree	ENSGT00390000010770	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000010770
HGNC	HGNC:13527	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13527
HOGENOM	HOG000230791	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230791&db=HOGENOM6
HOVERGEN	HBG000483	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000483&db=HOVERGEN
HPA	HPA031515	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031515
HPA	HPA057316	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA057316
InParanoid	Q9Y5K8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y5K8
IntAct	Q9Y5K8	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9Y5K8*
InterPro	IPR002699	http://www.ebi.ac.uk/interpro/entry/IPR002699
Jabion	51382	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=51382
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:51382	http://www.genome.jp/dbget-bin/www_bget?hsa:51382
KEGG_Orthology	KO:K02149	http://www.genome.jp/dbget-bin/www_bget?KO:K02149
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04966	http://www.genome.jp/kegg-bin/show_pathway?ko04966
KEGG_Pathway	ko05110	http://www.genome.jp/kegg-bin/show_pathway?ko05110
KEGG_Pathway	ko05120	http://www.genome.jp/kegg-bin/show_pathway?ko05120
KEGG_Pathway	ko05323	http://www.genome.jp/kegg-bin/show_pathway?ko05323
MIM	609398	http://www.ncbi.nlm.nih.gov/omim/609398
OMA	REEIFRM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=REEIFRM
OrthoDB	EOG091G0A10	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0A10
PANTHER	PTHR11671	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11671
PSORT	swissprot:VATD_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VATD_HUMAN
PSORT-B	swissprot:VATD_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VATD_HUMAN
PSORT2	swissprot:VATD_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VATD_HUMAN
Pfam	PF01813	http://pfam.xfam.org/family/PF01813
PharmGKB	PA25157	http://www.pharmgkb.org/do/serve?objId=PA25157&objCls=Gene
Phobius	swissprot:VATD_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VATD_HUMAN
PhylomeDB	Q9Y5K8	http://phylomedb.org/?seqid=Q9Y5K8
ProteinModelPortal	Q9Y5K8	http://www.proteinmodelportal.org/query/uniprot/Q9Y5K8
PubMed	10931946	http://www.ncbi.nlm.nih.gov/pubmed/10931946
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21844891	http://www.ncbi.nlm.nih.gov/pubmed/21844891
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-1222556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1222556
Reactome	R-HSA-6798695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6798695
Reactome	R-HSA-77387	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-77387
Reactome	R-HSA-917977	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917977
Reactome	R-HSA-983712	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983712
RefSeq	NP_057078	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_057078
SMR	Q9Y5K8	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9Y5K8
STRING	9606.ENSP00000216442	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000216442&targetmode=cogs
STRING	COG1394	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1394&targetmode=cogs
TIGRFAMs	TIGR00309	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00309
UCSC	uc001xjf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001xjf&org=rat
UniGene	Hs.272630	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.272630
UniProtKB	VATD_HUMAN	http://www.uniprot.org/uniprot/VATD_HUMAN
UniProtKB-AC	Q9Y5K8	http://www.uniprot.org/uniprot/Q9Y5K8
charge	swissprot:VATD_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VATD_HUMAN
eggNOG	COG1394	http://eggnogapi.embl.de/nog_data/html/tree/COG1394
eggNOG	KOG1647	http://eggnogapi.embl.de/nog_data/html/tree/KOG1647
epestfind	swissprot:VATD_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VATD_HUMAN
garnier	swissprot:VATD_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VATD_HUMAN
helixturnhelix	swissprot:VATD_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VATD_HUMAN
hmoment	swissprot:VATD_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VATD_HUMAN
iep	swissprot:VATD_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VATD_HUMAN
inforesidue	swissprot:VATD_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VATD_HUMAN
neXtProt	NX_Q9Y5K8	http://www.nextprot.org/db/entry/NX_Q9Y5K8
octanol	swissprot:VATD_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VATD_HUMAN
pepcoil	swissprot:VATD_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VATD_HUMAN
pepdigest	swissprot:VATD_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VATD_HUMAN
pepinfo	swissprot:VATD_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VATD_HUMAN
pepnet	swissprot:VATD_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VATD_HUMAN
pepstats	swissprot:VATD_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VATD_HUMAN
pepwheel	swissprot:VATD_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VATD_HUMAN
pepwindow	swissprot:VATD_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VATD_HUMAN
sigcleave	swissprot:VATD_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VATD_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	P2RX4_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q99571-1; Sequence=Displayed; Name=2; IsoId=Q99571-2; Sequence=VSP_053812; Note=No experimental confirmation available.; Name=3; IsoId=Q99571-3; Sequence=VSP_053813; 
# AltName	P2RX4_HUMAN	ATP receptor
# AltName	P2RX4_HUMAN	Purinergic receptor
# BioGrid	111064	31
# CCDS	CCDS58282	-. [Q99571-2]
# CCDS	CCDS9214	-. [Q99571-1]
# ChiTaRS	P2RX4	human
# DrugBank	DB09119	Eslicarbazepine acetate
# Ensembl	ENST00000337233	ENSP00000336607; ENSG00000135124. [Q99571-1]
# Ensembl	ENST00000359949	ENSP00000353032; ENSG00000135124. [Q99571-2]
# Ensembl	ENST00000542067	ENSP00000438329; ENSG00000135124. [Q99571-3]
# ExpressionAtlas	Q99571	baseline and differential
# FUNCTION	P2RX4_HUMAN	Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin. {ECO 0000269|PubMed 10515189}. 
# GO_component	GO:0005639	integral component of nuclear inner membrane; IBA:GO_Central.
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; ISS:BHF-UCL.
# GO_component	GO:0005887	integral component of plasma membrane; IMP:UniProtKB.
# GO_component	GO:0014069	postsynaptic density; IEA:Ensembl.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0030054	cell junction; IDA:BHF-UCL.
# GO_component	GO:0043025	neuronal cell body; IEA:Ensembl.
# GO_component	GO:0043195	terminal bouton; IEA:Ensembl.
# GO_component	GO:0043197	dendritic spine; IEA:Ensembl.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IDA:BHF-UCL.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0001614	purinergic nucleotide receptor activity; IDA:BHF-UCL.
# GO_function	GO:0004931	extracellular ATP-gated cation channel activity; IDA:UniProtKB.
# GO_function	GO:0005102	receptor binding; ISS:BHF-UCL.
# GO_function	GO:0005507	copper ion binding; ISS:BHF-UCL.
# GO_function	GO:0005524	ATP binding; IC:BHF-UCL.
# GO_function	GO:0008144	drug binding; IEA:Ensembl.
# GO_function	GO:0008270	zinc ion binding; ISS:BHF-UCL.
# GO_function	GO:0042803	protein homodimerization activity; NAS:BHF-UCL.
# GO_function	GO:0045296	cadherin binding; IPI:BHF-UCL.
# GO_process	GO:0001894	tissue homeostasis; NAS:BHF-UCL.
# GO_process	GO:0002028	regulation of sodium ion transport; ISS:BHF-UCL.
# GO_process	GO:0006810	transport; IDA:BHF-UCL.
# GO_process	GO:0007165	signal transduction; IDA:BHF-UCL.
# GO_process	GO:0007596	blood coagulation; TAS:Reactome.
# GO_process	GO:0008217	regulation of blood pressure; IMP:BHF-UCL.
# GO_process	GO:0010524	positive regulation of calcium ion transport into cytosol; IDA:BHF-UCL.
# GO_process	GO:0010614	negative regulation of cardiac muscle hypertrophy; IMP:BHF-UCL.
# GO_process	GO:0019228	neuronal action potential; IEA:Ensembl.
# GO_process	GO:0019233	sensory perception of pain; ISS:BHF-UCL.
# GO_process	GO:0032308	positive regulation of prostaglandin secretion; NAS:BHF-UCL.
# GO_process	GO:0033198	response to ATP; IDA:BHF-UCL.
# GO_process	GO:0034220	ion transmembrane transport; IDA:UniProtKB.
# GO_process	GO:0034405	response to fluid shear stress; IDA:BHF-UCL.
# GO_process	GO:0035590	purinergic nucleotide receptor signaling pathway; IMP:BHF-UCL.
# GO_process	GO:0042118	endothelial cell activation; TAS:BHF-UCL.
# GO_process	GO:0045429	positive regulation of nitric oxide biosynthetic process; NAS:BHF-UCL.
# GO_process	GO:0050850	positive regulation of calcium-mediated signaling; IDA:BHF-UCL.
# GO_process	GO:0051260	protein homooligomerization; IEA:Ensembl.
# GO_process	GO:0051899	membrane depolarization; IDA:BHF-UCL.
# GO_process	GO:0051928	positive regulation of calcium ion transport; NAS:BHF-UCL.
# GO_process	GO:0055117	regulation of cardiac muscle contraction; IMP:BHF-UCL.
# GO_process	GO:0055119	relaxation of cardiac muscle; IMP:BHF-UCL.
# GO_process	GO:0071318	cellular response to ATP; IDA:UniProtKB.
# GO_process	GO:0097190	apoptotic signaling pathway; IDA:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.490.10	-; 1.
# Genevisible	Q99571	HS
# HGNC	HGNC:8535	P2RX4
# INTERACTION	P2RX4_HUMAN	P26371 KRTAP5-9; NbExp=3; IntAct=EBI-2828248, EBI-3958099; Q7Z3S9 NOTCH2NL; NbExp=5; IntAct=EBI-2828248, EBI-945833; Q9NQM4 PIH1D3; NbExp=3; IntAct=EBI-2828248, EBI-10239299; 
# IntAct	Q99571	8
# InterPro	IPR001429	P2X_purnocptor
# InterPro	IPR003047	P2X4_purnocptor
# InterPro	IPR027309	P2X_extracellular_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# MIM	600846	gene
# Organism	P2RX4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10125	PTHR10125
# PANTHER	PTHR10125:SF18	PTHR10125:SF18
# PIRSF	PIRSF005713	P2X_purinoceptor
# PRINTS	PR01307	P2XRECEPTOR
# PRINTS	PR01311	P2X4RECEPTOR
# PROSITE	PS01212	P2X_RECEPTOR
# Pfam	PF00864	P2X_receptor
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-139853	Elevation of cytosolic Ca2+ levels
# Reactome	R-HSA-418346	Platelet homeostasis
# RecName	P2RX4_HUMAN	P2X purinoceptor 4
# RefSeq	NP_001243725	NM_001256796.1. [Q99571-2]
# RefSeq	NP_001248326	NM_001261397.1. [Q99571-3]
# RefSeq	NP_002551	NM_002560.2. [Q99571-1]
# SIMILARITY	Belongs to the P2X receptor family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	P2RX4_HUMAN	Membrane {ECO 0000269|PubMed 10515189}; Multi-pass membrane protein {ECO 0000269|PubMed 10515189}. 
# SUBUNIT	Functional P2XRs are organized as homomeric and heteromeric trimers. {ECO	0000250}. 
# TCDB	1.A.7.1	the atp-gated p2x receptor cation channel (p2x receptor) family
# TIGRFAMs	TIGR00863	P2X
# UCSC	uc001tzr	human. [Q99571-1]
# WEB RESOURCE	P2RX4_HUMAN	Name=Wikipedia; Note=P2X receptor entry; URL="https //en.wikipedia.org/wiki/P2X_receptor";
# eggNOG	ENOG410IFJF	Eukaryota
# eggNOG	ENOG410XR0C	LUCA
BLAST	swissprot:P2RX4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:P2RX4_HUMAN
BioCyc	ZFISH:ENSG00000135124-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000135124-MONOMER
COXPRESdb	5025	http://coxpresdb.jp/data/gene/5025.shtml
CleanEx	HS_P2RX4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_P2RX4
DOI	10.1016/S0304-3940(99)00653-9	http://dx.doi.org/10.1016/S0304-3940(99)00653-9
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB09119	http://www.drugbank.ca/drugs/DB09119
EMBL	AC069209	http://www.ebi.ac.uk/ena/data/view/AC069209
EMBL	AF000234	http://www.ebi.ac.uk/ena/data/view/AF000234
EMBL	AF012903	http://www.ebi.ac.uk/ena/data/view/AF012903
EMBL	AF191093	http://www.ebi.ac.uk/ena/data/view/AF191093
EMBL	BC033826	http://www.ebi.ac.uk/ena/data/view/BC033826
EMBL	BT019738	http://www.ebi.ac.uk/ena/data/view/BT019738
EMBL	BT019739	http://www.ebi.ac.uk/ena/data/view/BT019739
EMBL	U83993	http://www.ebi.ac.uk/ena/data/view/U83993
EMBL	U85971	http://www.ebi.ac.uk/ena/data/view/U85971
EMBL	U85972	http://www.ebi.ac.uk/ena/data/view/U85972
EMBL	U85973	http://www.ebi.ac.uk/ena/data/view/U85973
EMBL	U85974	http://www.ebi.ac.uk/ena/data/view/U85974
EMBL	U85975	http://www.ebi.ac.uk/ena/data/view/U85975
EMBL	U87270	http://www.ebi.ac.uk/ena/data/view/U87270
EMBL	Y07684	http://www.ebi.ac.uk/ena/data/view/Y07684
Ensembl	ENST00000337233	http://www.ensembl.org/id/ENST00000337233
Ensembl	ENST00000359949	http://www.ensembl.org/id/ENST00000359949
Ensembl	ENST00000542067	http://www.ensembl.org/id/ENST00000542067
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005639	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005639
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0014069	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014069
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0043195	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043195
GO_component	GO:0043197	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043197
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0001614	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001614
GO_function	GO:0004931	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004931
GO_function	GO:0005102	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005102
GO_function	GO:0005507	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005507
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0008144	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008144
GO_function	GO:0008270	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_function	GO:0045296	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045296
GO_process	GO:0001894	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001894
GO_process	GO:0002028	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002028
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007596	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007596
GO_process	GO:0008217	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008217
GO_process	GO:0010524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010524
GO_process	GO:0010614	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010614
GO_process	GO:0019228	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019228
GO_process	GO:0019233	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019233
GO_process	GO:0032308	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032308
GO_process	GO:0033198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033198
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0034405	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034405
GO_process	GO:0035590	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035590
GO_process	GO:0042118	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042118
GO_process	GO:0045429	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045429
GO_process	GO:0050850	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050850
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:0051899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051899
GO_process	GO:0051928	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051928
GO_process	GO:0055117	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055117
GO_process	GO:0055119	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055119
GO_process	GO:0071318	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071318
GO_process	GO:0097190	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097190
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.490.10	http://www.cathdb.info/version/latest/superfamily/2.60.490.10
GeneCards	P2RX4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=P2RX4
GeneID	5025	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5025
GeneTree	ENSGT00390000016028	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000016028
HGNC	HGNC:8535	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:8535
HOGENOM	HOG000232042	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000232042&db=HOGENOM6
HOVERGEN	HBG053086	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053086&db=HOVERGEN
HPA	HPA039494	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA039494
InParanoid	Q99571	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q99571
IntAct	Q99571	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q99571*
InterPro	IPR001429	http://www.ebi.ac.uk/interpro/entry/IPR001429
InterPro	IPR003047	http://www.ebi.ac.uk/interpro/entry/IPR003047
InterPro	IPR027309	http://www.ebi.ac.uk/interpro/entry/IPR027309
Jabion	5025	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=5025
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:5025	http://www.genome.jp/dbget-bin/www_bget?hsa:5025
KEGG_Orthology	KO:K05218	http://www.genome.jp/dbget-bin/www_bget?KO:K05218
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
MIM	600846	http://www.ncbi.nlm.nih.gov/omim/600846
OMA	TMINVGS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TMINVGS
OrthoDB	EOG091G0A2U	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0A2U
PANTHER	PTHR10125	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10125
PANTHER	PTHR10125:SF18	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10125:SF18
PRINTS	PR01307	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01307
PRINTS	PR01311	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01311
PROSITE	PS01212	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01212
PSORT	swissprot:P2RX4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:P2RX4_HUMAN
PSORT-B	swissprot:P2RX4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:P2RX4_HUMAN
PSORT2	swissprot:P2RX4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:P2RX4_HUMAN
Pfam	PF00864	http://pfam.xfam.org/family/PF00864
PharmGKB	PA32864	http://www.pharmgkb.org/do/serve?objId=PA32864&objCls=Gene
Phobius	swissprot:P2RX4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:P2RX4_HUMAN
PhylomeDB	Q99571	http://phylomedb.org/?seqid=Q99571
ProteinModelPortal	Q99571	http://www.proteinmodelportal.org/query/uniprot/Q99571
PubMed	10515189	http://www.ncbi.nlm.nih.gov/pubmed/10515189
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	9016352	http://www.ncbi.nlm.nih.gov/pubmed/9016352
Reactome	R-HSA-139853	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-139853
Reactome	R-HSA-418346	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418346
RefSeq	NP_001243725	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243725
RefSeq	NP_001248326	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001248326
RefSeq	NP_002551	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002551
SMR	Q99571	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q99571
STRING	9606.ENSP00000336607	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000336607&targetmode=cogs
TCDB	1.A.7.1	http://www.tcdb.org/search/result.php?tc=1.A.7.1
TIGRFAMs	TIGR00863	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00863
UCSC	uc001tzr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001tzr&org=rat
UniGene	Hs.321709	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.321709
UniProtKB	P2RX4_HUMAN	http://www.uniprot.org/uniprot/P2RX4_HUMAN
UniProtKB-AC	Q99571	http://www.uniprot.org/uniprot/Q99571
charge	swissprot:P2RX4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:P2RX4_HUMAN
eggNOG	ENOG410IFJF	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IFJF
eggNOG	ENOG410XR0C	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XR0C
epestfind	swissprot:P2RX4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:P2RX4_HUMAN
garnier	swissprot:P2RX4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:P2RX4_HUMAN
helixturnhelix	swissprot:P2RX4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:P2RX4_HUMAN
hmoment	swissprot:P2RX4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:P2RX4_HUMAN
iep	swissprot:P2RX4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:P2RX4_HUMAN
inforesidue	swissprot:P2RX4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:P2RX4_HUMAN
neXtProt	NX_Q99571	http://www.nextprot.org/db/entry/NX_Q99571
octanol	swissprot:P2RX4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:P2RX4_HUMAN
pepcoil	swissprot:P2RX4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:P2RX4_HUMAN
pepdigest	swissprot:P2RX4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:P2RX4_HUMAN
pepinfo	swissprot:P2RX4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:P2RX4_HUMAN
pepnet	swissprot:P2RX4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:P2RX4_HUMAN
pepstats	swissprot:P2RX4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:P2RX4_HUMAN
pepwheel	swissprot:P2RX4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:P2RX4_HUMAN
pepwindow	swissprot:P2RX4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:P2RX4_HUMAN
sigcleave	swissprot:P2RX4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:P2RX4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5BKX6-1; Sequence=Displayed; Name=2; IsoId=Q5BKX6-2; Sequence=VSP_033540, VSP_033541; Name=3; IsoId=Q5BKX6-3; Sequence=VSP_033540, VSP_033541, VSP_033542; Note=No experimental confirmation available. Ref.1 (BAC87328) sequence is in conflict in position: 787	E->K. {ECO:0000305}; 
# CCDS	CCDS34948	-. [Q5BKX6-3]
# CCDS	CCDS69550	-. [Q5BKX6-2]
# CDD	cd06174	MFS; 2
# Ensembl	ENST00000024061	ENSP00000024061; ENSG00000022567. [Q5BKX6-3]
# Ensembl	ENST00000519067	ENSP00000429059; ENSG00000022567. [Q5BKX6-2]
# ExpressionAtlas	Q5BKX6	baseline and differential
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	S45A4_HUMAN	GO 0008506 sucrose proton symporter activity; ISS ParkinsonsUK-UCL.
# GO_process	GO:0015770	sucrose transport; ISS:ParkinsonsUK-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q5BKX6	HS
# HGNC	HGNC:29196	SLC45A4
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02001	Solute carrier family
# Organism	S45A4_HUMAN	Homo sapiens (Human)
# Proteomes	UP000005640	Chromosome 8
# RecName	S45A4_HUMAN	Solute carrier family 45 member 4
# RefSeq	NP_001073900	NM_001080431.2. [Q5BKX6-3]
# RefSeq	NP_001273575	NM_001286646.1
# RefSeq	NP_001273577	NM_001286648.1. [Q5BKX6-2]
# SEQUENCE CAUTION	Sequence=AAH90891.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S45A4_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.2.4:the glycoside-pentoside-hexuronide (gph)	cation symporter family
# UCSC	uc003ywc	human. [Q5BKX6-1]
# eggNOG	ENOG410XPTR	LUCA
# eggNOG	KOG0637	Eukaryota
BLAST	swissprot:S45A4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S45A4_HUMAN
COXPRESdb	57210	http://coxpresdb.jp/data/gene/57210.shtml
CleanEx	HS_SLC45A4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC45A4
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04406	http://dx.doi.org/10.1038/nature04406
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1093/dnares/6.5.329	http://dx.doi.org/10.1093/dnares/6.5.329
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB032952	http://www.ebi.ac.uk/ena/data/view/AB032952
EMBL	AC011676	http://www.ebi.ac.uk/ena/data/view/AC011676
EMBL	AK128212	http://www.ebi.ac.uk/ena/data/view/AK128212
EMBL	BC090891	http://www.ebi.ac.uk/ena/data/view/BC090891
Ensembl	ENST00000024061	http://www.ensembl.org/id/ENST00000024061
Ensembl	ENST00000519067	http://www.ensembl.org/id/ENST00000519067
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0008506	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008506
GO_process	GO:0015770	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015770
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC45A4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC45A4
GeneID	57210	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57210
GeneTree	ENSGT00390000018882	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000018882
HGNC	HGNC:29196	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:29196
HOGENOM	HOG000154239	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000154239&db=HOGENOM6
HOVERGEN	HBG108452	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108452&db=HOVERGEN
HPA	HPA023154	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA023154
InParanoid	Q5BKX6	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q5BKX6
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	57210	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=57210
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:57210	http://www.genome.jp/dbget-bin/www_bget?hsa:57210
KEGG_Orthology	KO:K15378	http://www.genome.jp/dbget-bin/www_bget?KO:K15378
PSORT	swissprot:S45A4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S45A4_HUMAN
PSORT-B	swissprot:S45A4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S45A4_HUMAN
PSORT2	swissprot:S45A4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S45A4_HUMAN
Phobius	swissprot:S45A4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S45A4_HUMAN
PhylomeDB	Q5BKX6	http://phylomedb.org/?seqid=Q5BKX6
ProteinModelPortal	Q5BKX6	http://www.proteinmodelportal.org/query/uniprot/Q5BKX6
PubMed	10574461	http://www.ncbi.nlm.nih.gov/pubmed/10574461
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16421571	http://www.ncbi.nlm.nih.gov/pubmed/16421571
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
RefSeq	NP_001073900	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001073900
RefSeq	NP_001273575	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273575
RefSeq	NP_001273577	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273577
STRING	9606.ENSP00000024061	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000024061&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.2.4	http://www.tcdb.org/search/result.php?tc=2.A.2.4
UCSC	uc003ywc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ywc&org=rat
UniGene	Hs.372492	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.372492
UniProtKB	S45A4_HUMAN	http://www.uniprot.org/uniprot/S45A4_HUMAN
UniProtKB-AC	Q5BKX6	http://www.uniprot.org/uniprot/Q5BKX6
charge	swissprot:S45A4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S45A4_HUMAN
eggNOG	ENOG410XPTR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPTR
eggNOG	KOG0637	http://eggnogapi.embl.de/nog_data/html/tree/KOG0637
epestfind	swissprot:S45A4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S45A4_HUMAN
garnier	swissprot:S45A4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S45A4_HUMAN
helixturnhelix	swissprot:S45A4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S45A4_HUMAN
hmoment	swissprot:S45A4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S45A4_HUMAN
iep	swissprot:S45A4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S45A4_HUMAN
inforesidue	swissprot:S45A4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S45A4_HUMAN
neXtProt	NX_Q5BKX6	http://www.nextprot.org/db/entry/NX_Q5BKX6
octanol	swissprot:S45A4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S45A4_HUMAN
pepcoil	swissprot:S45A4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S45A4_HUMAN
pepdigest	swissprot:S45A4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S45A4_HUMAN
pepinfo	swissprot:S45A4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S45A4_HUMAN
pepnet	swissprot:S45A4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S45A4_HUMAN
pepstats	swissprot:S45A4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S45A4_HUMAN
pepwheel	swissprot:S45A4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S45A4_HUMAN
pepwindow	swissprot:S45A4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S45A4_HUMAN
sigcleave	swissprot:S45A4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S45A4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	PANX2_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=3; IsoId=Q96RD6-3; Sequence=Displayed; Name=1; IsoId=Q96RD6-1; Sequence=VSP_002677; Name=2; IsoId=Q96RD6-2; Sequence=VSP_039092, VSP_002677; 
# CCDS	CCDS14085	-. [Q96RD6-3]
# CCDS	CCDS54544	-. [Q96RD6-1]
# ChiTaRS	PANX2	human
# Ensembl	ENST00000159647	ENSP00000159647; ENSG00000073150. [Q96RD6-1]
# Ensembl	ENST00000395842	ENSP00000379183; ENSG00000073150. [Q96RD6-3]
# ExpressionAtlas	Q96RD6	baseline and differential
# FUNCTION	PANX2_HUMAN	Structural component of the gap junctions and the hemichannels. {ECO 0000250}. 
# GO_component	GO:0005737	cytoplasm; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005921	gap junction; IEA:UniProtKB-SubCell.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0055077	gap junction hemi-channel activity; ISS:UniProtKB.
# GO_process	GO:0002931	response to ischemia; IEA:Ensembl.
# GO_process	GO:0006811	ion transport; IEA:UniProtKB-KW.
# GO_process	GO:0034214	protein hexamerization; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# Genevisible	Q96RD6	HS
# HGNC	HGNC:8600	PANX2
# InterPro	IPR000990	Innexin
# KEGG_Brite	ko02000	Transporters
# MIM	608421	gene
# Organism	PANX2_HUMAN	Homo sapiens (Human)
# PROSITE	PS51013	PANNEXIN
# Pfam	PF00876	Innexin
# Proteomes	UP000005640	Chromosome 22
# Reactome	R-HSA-112303	Electric Transmission Across Gap Junctions
# RecName	PANX2_HUMAN	Pannexin-2
# RefSeq	NP_001153772	NM_001160300.1. [Q96RD6-1]
# RefSeq	NP_443071	NM_052839.3. [Q96RD6-3]
# SIMILARITY	Belongs to the pannexin family. {ECO:0000255|PROSITE- ProRule	PRU00351}. 
# SUBCELLULAR LOCATION	PANX2_HUMAN	Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00351}. Cell junction, gap junction. 
# SUBUNIT	Forms PANX1/PANX2-heteromeric intercellular channels on coexpression in paired Xenopus oocytes. Does not form homomeric channels (By similarity). {ECO	0000250}. 
# TCDB	1.A.25.2	the gap junction-forming innexin (innexin) family
# UCSC	uc003bjn	human. [Q96RD6-3]
# WEB RESOURCE	PANX2_HUMAN	Name=Wikipedia; Note=Pannexin entry; URL="https //en.wikipedia.org/wiki/Pannexin";
# eggNOG	ENOG410IGKS	Eukaryota
# eggNOG	ENOG4110P9D	LUCA
BLAST	swissprot:PANX2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:PANX2_HUMAN
COXPRESdb	56666	http://coxpresdb.jp/data/gene/56666.shtml
CleanEx	HS_PANX2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_PANX2
DOI	10.1016/j.ygeno.2003.09.025	http://dx.doi.org/10.1016/j.ygeno.2003.09.025
DOI	10.1038/990031	http://dx.doi.org/10.1038/990031
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
EMBL	AF398510	http://www.ebi.ac.uk/ena/data/view/AF398510
EMBL	AF398511	http://www.ebi.ac.uk/ena/data/view/AF398511
EMBL	AK299910	http://www.ebi.ac.uk/ena/data/view/AK299910
EMBL	AL022328	http://www.ebi.ac.uk/ena/data/view/AL022328
Ensembl	ENST00000159647	http://www.ensembl.org/id/ENST00000159647
Ensembl	ENST00000395842	http://www.ensembl.org/id/ENST00000395842
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005921	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005921
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0055077	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055077
GO_process	GO:0002931	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002931
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0034214	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034214
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GeneCards	PANX2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=PANX2
GeneID	56666	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56666
GeneTree	ENSGT00390000009703	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000009703
H-InvDB	HIX0016605	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0016605
HGNC	HGNC:8600	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:8600
HOGENOM	HOG000082414	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000082414&db=HOGENOM6
HOVERGEN	HBG053498	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053498&db=HOVERGEN
HPA	HPA039117	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA039117
InParanoid	Q96RD6	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96RD6
IntAct	Q96RD6	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96RD6*
InterPro	IPR000990	http://www.ebi.ac.uk/interpro/entry/IPR000990
Jabion	56666	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=56666
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:56666	http://www.genome.jp/dbget-bin/www_bget?hsa:56666
KEGG_Orthology	KO:K03443	http://www.genome.jp/dbget-bin/www_bget?KO:K03443
MIM	608421	http://www.ncbi.nlm.nih.gov/omim/608421
OMA	RAAHHYK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RAAHHYK
OrthoDB	EOG091G086D	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G086D
PROSITE	PS51013	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51013
PSORT	swissprot:PANX2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:PANX2_HUMAN
PSORT-B	swissprot:PANX2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:PANX2_HUMAN
PSORT2	swissprot:PANX2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:PANX2_HUMAN
Pfam	PF00876	http://pfam.xfam.org/family/PF00876
PharmGKB	PA32930	http://www.pharmgkb.org/do/serve?objId=PA32930&objCls=Gene
Phobius	swissprot:PANX2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:PANX2_HUMAN
PhylomeDB	Q96RD6	http://phylomedb.org/?seqid=Q96RD6
ProteinModelPortal	Q96RD6	http://www.proteinmodelportal.org/query/uniprot/Q96RD6
PubMed	10591208	http://www.ncbi.nlm.nih.gov/pubmed/10591208
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15028292	http://www.ncbi.nlm.nih.gov/pubmed/15028292
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
Reactome	R-HSA-112303	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112303
RefSeq	NP_001153772	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001153772
RefSeq	NP_443071	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_443071
STRING	9606.ENSP00000379183	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000379183&targetmode=cogs
TCDB	1.A.25.2	http://www.tcdb.org/search/result.php?tc=1.A.25.2
UCSC	uc003bjn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003bjn&org=rat
UniGene	Hs.440092	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.440092
UniProtKB	PANX2_HUMAN	http://www.uniprot.org/uniprot/PANX2_HUMAN
UniProtKB-AC	Q96RD6	http://www.uniprot.org/uniprot/Q96RD6
charge	swissprot:PANX2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:PANX2_HUMAN
eggNOG	ENOG410IGKS	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IGKS
eggNOG	ENOG4110P9D	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110P9D
epestfind	swissprot:PANX2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:PANX2_HUMAN
garnier	swissprot:PANX2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:PANX2_HUMAN
helixturnhelix	swissprot:PANX2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:PANX2_HUMAN
hmoment	swissprot:PANX2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:PANX2_HUMAN
iep	swissprot:PANX2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:PANX2_HUMAN
inforesidue	swissprot:PANX2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:PANX2_HUMAN
neXtProt	NX_Q96RD6	http://www.nextprot.org/db/entry/NX_Q96RD6
octanol	swissprot:PANX2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:PANX2_HUMAN
pepcoil	swissprot:PANX2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:PANX2_HUMAN
pepdigest	swissprot:PANX2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:PANX2_HUMAN
pepinfo	swissprot:PANX2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:PANX2_HUMAN
pepnet	swissprot:PANX2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:PANX2_HUMAN
pepstats	swissprot:PANX2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:PANX2_HUMAN
pepwheel	swissprot:PANX2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:PANX2_HUMAN
pepwindow	swissprot:PANX2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:PANX2_HUMAN
sigcleave	swissprot:PANX2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:PANX2_HUMAN
## Database	ID	URL or Descriptions
# AltName	ADT2_HUMAN	ADP,ATP carrier protein 2
# AltName	ADT2_HUMAN	ADP,ATP carrier protein, fibroblast isoform
# AltName	ADT2_HUMAN	Adenine nucleotide translocator 2
# AltName	ADT2_HUMAN	Solute carrier family 25 member 5
# AltName	ADT2_HUMAN	Solute carrier family 25 member 5
# BioGrid	106789	131
# ChiTaRS	SLC25A5	human
# DrugBank	DB00720	Clodronate
# Ensembl	ENST00000317881	ENSP00000360671; ENSG00000005022
# FUNCTION	ADT2_HUMAN	Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. {ECO 0000269|PubMed 20797633}. 
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0031012	extracellular matrix; IDA:BHF-UCL.
# GO_component	GO:0042645	mitochondrial nucleoid; IDA:BHF-UCL.
# GO_component	GO:0043209	myelin sheath; IEA:Ensembl.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_component	GO:0071817	MMXD complex; IDA:UniProtKB.
# GO_function	GO:0015207	adenine transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0031625	ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
# GO_function	GO:0044822	poly(A) RNA binding; IDA:UniProtKB.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007059	chromosome segregation; IEA:UniProtKB-KW.
# GO_process	GO:0008284	positive regulation of cell proliferation; IMP:UniProtKB.
# GO_process	GO:0016032	viral process; IEA:UniProtKB-KW.
# GO_process	GO:0050796	regulation of insulin secretion; TAS:Reactome.
# GO_process	GO:1901029	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003723	RNA binding
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007005	mitochondrion organization
# GOslim_process	GO:0007059	chromosome segregation
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# GOslim_process	GO:0061024	membrane organization
# Gene3D	1.50.40.10	-; 1.
# Genevisible	P05141	HS
# HGNC	HGNC:10991	SLC25A5
# INTERACTION	ADT2_HUMAN	Q5S007 LRRK2; NbExp=2; IntAct=EBI-355133, EBI-5323863; Q9Y6E7 SIRT4; NbExp=2; IntAct=EBI-355133, EBI-2606540; Q8N357 SLC35F6; NbExp=2; IntAct=EBI-355133, EBI-713484; 
# IntAct	P05141	81
# InterPro	IPR002067	Mit_carrier
# InterPro	IPR002113	Aden_trnslctor
# InterPro	IPR018108	Mitochondrial_sb/sol_carrier
# InterPro	IPR023395	Mt_carrier_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# KEGG_Pathway	ko05166	HTLV-I infection
# MIM	300150	gene
# MISCELLANEOUS	The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity). {ECO	0000250}. 
# Organism	ADT2_HUMAN	Homo sapiens (Human)
# PIR	A29132	A29132
# PRINTS	PR00926	MITOCARRIER
# PRINTS	PR00927	ADPTRNSLCASE
# PROSITE	PS50920	SOLCAR; 3
# Pfam	PF00153	Mito_carr; 3
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-180897	Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
# Reactome	R-HSA-422356	Regulation of insulin secretion
# RecName	ADT2_HUMAN	ADP/ATP translocase 2
# RecName	ADT2_HUMAN	ADP/ATP translocase 2, N-terminally processed
# RefSeq	NP_001143	NM_001152.4
# SIMILARITY	Belongs to the mitochondrial carrier (TC 2.A.29) family. {ECO	0000305}. 
# SIMILARITY	Contains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule	PRU00282}.
# SUBCELLULAR LOCATION	ADT2_HUMAN	Mitochondrion inner membrane; Multi-pass membrane protein. 
# SUBUNIT	ADT2_HUMAN	Homodimer. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with HIV-1 Vpr. {ECO 0000269|PubMed 16120388, ECO 0000269|PubMed 20797633}. 
# SUPFAM	SSF103506	SSF103506
# TCDB	2.A.29.1	the mitochondrial carrier (mc) family
# UCSC	uc004erh	human
# eggNOG	ENOG410XNW0	LUCA
# eggNOG	KOG0749	Eukaryota
BLAST	swissprot:ADT2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ADT2_HUMAN
BioCyc	ZFISH:ENSG00000005022-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000005022-MONOMER
COXPRESdb	292	http://coxpresdb.jp/data/gene/292.shtml
CleanEx	HS_SLC25A5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC25A5
DIP	DIP-33873N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-33873N
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.mito.2004.06.012	http://dx.doi.org/10.1016/j.mito.2004.06.012
DOI	10.1016/j.molcel.2010.07.029	http://dx.doi.org/10.1016/j.molcel.2010.07.029
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.85.2.377	http://dx.doi.org/10.1073/pnas.85.2.377
DOI	10.1074/mcp.M111.012658	http://dx.doi.org/10.1074/mcp.M111.012658
DOI	10.1074/mcp.M111.015131	http://dx.doi.org/10.1074/mcp.M111.015131
DOI	10.1074/mcp.O113.027870	http://dx.doi.org/10.1074/mcp.O113.027870
DOI	10.1093/nar/24.20.4034	http://dx.doi.org/10.1093/nar/24.20.4034
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DrugBank	DB00720	http://www.drugbank.ca/drugs/DB00720
EMBL	AC004000	http://www.ebi.ac.uk/ena/data/view/AC004000
EMBL	AK315292	http://www.ebi.ac.uk/ena/data/view/AK315292
EMBL	BC056160	http://www.ebi.ac.uk/ena/data/view/BC056160
EMBL	J02683	http://www.ebi.ac.uk/ena/data/view/J02683
EMBL	J03591	http://www.ebi.ac.uk/ena/data/view/J03591
EMBL	L78810	http://www.ebi.ac.uk/ena/data/view/L78810
EMBL	M57424	http://www.ebi.ac.uk/ena/data/view/M57424
Ensembl	ENST00000317881	http://www.ensembl.org/id/ENST00000317881
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0031012	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031012
GO_component	GO:0042645	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042645
GO_component	GO:0043209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043209
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_component	GO:0071817	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071817
GO_function	GO:0015207	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015207
GO_function	GO:0031625	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031625
GO_function	GO:0044822	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044822
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007059	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059
GO_process	GO:0008284	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008284
GO_process	GO:0016032	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016032
GO_process	GO:0050796	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050796
GO_process	GO:1901029	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901029
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003723	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007005
GOslim_process	GO:0007059	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
Gene3D	1.50.40.10	http://www.cathdb.info/version/latest/superfamily/1.50.40.10
GeneCards	SLC25A5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC25A5
GeneID	292	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=292
GeneTree	ENSGT00390000011543	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000011543
H-InvDB	HIX0028379	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0028379
HGNC	HGNC:10991	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10991
HOVERGEN	HBG108348	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108348&db=HOVERGEN
HPA	HPA060665	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA060665
InParanoid	P05141	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P05141
IntAct	P05141	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P05141*
InterPro	IPR002067	http://www.ebi.ac.uk/interpro/entry/IPR002067
InterPro	IPR002113	http://www.ebi.ac.uk/interpro/entry/IPR002113
InterPro	IPR018108	http://www.ebi.ac.uk/interpro/entry/IPR018108
InterPro	IPR023395	http://www.ebi.ac.uk/interpro/entry/IPR023395
Jabion	292	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=292
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:292	http://www.genome.jp/dbget-bin/www_bget?hsa:292
KEGG_Orthology	KO:K05863	http://www.genome.jp/dbget-bin/www_bget?KO:K05863
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
KEGG_Pathway	ko05166	http://www.genome.jp/kegg-bin/show_pathway?ko05166
MIM	300150	http://www.ncbi.nlm.nih.gov/omim/300150
MINT	MINT-1162449	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1162449
OMA	CFARTYK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CFARTYK
OrthoDB	EOG091G0ULB	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0ULB
PRINTS	PR00926	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00926
PRINTS	PR00927	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00927
PROSITE	PS50920	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50920
PSORT	swissprot:ADT2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ADT2_HUMAN
PSORT-B	swissprot:ADT2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ADT2_HUMAN
PSORT2	swissprot:ADT2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ADT2_HUMAN
Pfam	PF00153	http://pfam.xfam.org/family/PF00153
PharmGKB	PA35867	http://www.pharmgkb.org/do/serve?objId=PA35867&objCls=Gene
Phobius	swissprot:ADT2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ADT2_HUMAN
PhylomeDB	P05141	http://phylomedb.org/?seqid=P05141
ProteinModelPortal	P05141	http://www.proteinmodelportal.org/query/uniprot/P05141
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	16120388	http://www.ncbi.nlm.nih.gov/pubmed/16120388
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	20797633	http://www.ncbi.nlm.nih.gov/pubmed/20797633
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	2168878	http://www.ncbi.nlm.nih.gov/pubmed/2168878
PubMed	21908771	http://www.ncbi.nlm.nih.gov/pubmed/21908771
PubMed	22223895	http://www.ncbi.nlm.nih.gov/pubmed/22223895
PubMed	24129315	http://www.ncbi.nlm.nih.gov/pubmed/24129315
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	2829183	http://www.ncbi.nlm.nih.gov/pubmed/2829183
PubMed	3031073	http://www.ncbi.nlm.nih.gov/pubmed/3031073
PubMed	8918809	http://www.ncbi.nlm.nih.gov/pubmed/8918809
Reactome	R-HSA-180897	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-180897
Reactome	R-HSA-422356	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-422356
RefSeq	NP_001143	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001143
SMR	P05141	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P05141
STRING	9606.ENSP00000360671	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000360671&targetmode=cogs
SUPFAM	SSF103506	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103506
TCDB	2.A.29.1	http://www.tcdb.org/search/result.php?tc=2.A.29.1
UCSC	uc004erh	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004erh&org=rat
UniGene	Hs.632282	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.632282
UniProtKB	ADT2_HUMAN	http://www.uniprot.org/uniprot/ADT2_HUMAN
UniProtKB-AC	P05141	http://www.uniprot.org/uniprot/P05141
charge	swissprot:ADT2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ADT2_HUMAN
eggNOG	ENOG410XNW0	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNW0
eggNOG	KOG0749	http://eggnogapi.embl.de/nog_data/html/tree/KOG0749
epestfind	swissprot:ADT2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ADT2_HUMAN
garnier	swissprot:ADT2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ADT2_HUMAN
helixturnhelix	swissprot:ADT2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ADT2_HUMAN
hmoment	swissprot:ADT2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ADT2_HUMAN
iep	swissprot:ADT2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ADT2_HUMAN
inforesidue	swissprot:ADT2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ADT2_HUMAN
neXtProt	NX_P05141	http://www.nextprot.org/db/entry/NX_P05141
octanol	swissprot:ADT2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ADT2_HUMAN
pepcoil	swissprot:ADT2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ADT2_HUMAN
pepdigest	swissprot:ADT2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ADT2_HUMAN
pepinfo	swissprot:ADT2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ADT2_HUMAN
pepnet	swissprot:ADT2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ADT2_HUMAN
pepstats	swissprot:ADT2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ADT2_HUMAN
pepwheel	swissprot:ADT2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ADT2_HUMAN
pepwindow	swissprot:ADT2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ADT2_HUMAN
sigcleave	swissprot:ADT2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ADT2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNK4_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=KT4.1a; IsoId=Q9NYG8-1; Sequence=Displayed; Name=2; Synonyms=KT4.1b; IsoId=Q9NYG8-2; Sequence=VSP_006689; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 
# AltName	KCNK4_HUMAN	Two pore potassium channel KT4.1
# AltName	TWIK-related arachidonic acid-stimulated potassium channel protein {ECO:0000303|PubMed	23341632}
# BioGrid	119122	2
# CCDS	CCDS8067	-. [Q9NYG8-1]
# DOMAIN	KCNK4_HUMAN	Channel opening is brought about by a conformation change that involves buckling of the second transmembrane helix and affects the position and orientation of the fourth transmembrane helix. {ECO 0000269|PubMed 25471887, ECO 0000269|PubMed 25500157}. 
# ENZYME REGULATION	KCNK4_HUMAN	Activated by arachidonic acid. {ECO 0000269|PubMed 22282805, ECO 0000269|PubMed 25500157}. 
# Ensembl	ENST00000394525	ENSP00000378033; ENSG00000182450. [Q9NYG8-1]
# Ensembl	ENST00000422670	ENSP00000402797; ENSG00000182450. [Q9NYG8-1]
# Ensembl	ENST00000539216	ENSP00000444948; ENSG00000182450. [Q9NYG8-1]
# ExpressionAtlas	Q9NYG8	baseline and differential
# FUNCTION	KCNK4_HUMAN	Voltage-insensitive potassium channel (PubMed 22282805). Channel opening is triggered by mechanical forces that deform the membrane (PubMed 22282805, PubMed 25471887, PubMed 25500157). Channel opening is triggered by raising the intracellular pH to basic levels (By similarity). The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (By similarity). Plays a role in the perception of pain caused by heat (By similarity). Plays a role in the sensory perception of pain caused by pressure (By similarity). {ECO 0000250|UniProtKB G3V8V5, ECO 0000250|UniProtKB O88454, ECO 0000269|PubMed 22282805, ECO 0000269|PubMed 25471887, ECO 0000269|PubMed 25500157}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IMP:UniProtKB.
# GO_component	GO:0034705	potassium channel complex; IDA:UniProtKB.
# GO_function	GO:0005244	voltage-gated ion channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0005267	potassium channel activity; IDA:UniProtKB.
# GO_function	GO:0022841	potassium ion leak channel activity; IBA:GO_Central.
# GO_function	GO:0097604	temperature-gated cation channel activity; ISS:UniProtKB.
# GO_function	GO:0098782	mechanically-gated potassium channel activity; IDA:UniProtKB.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0007613	memory; IEA:Ensembl.
# GO_process	GO:0019233	sensory perception of pain; ISS:UniProtKB.
# GO_process	GO:0030322	stabilization of membrane potential; IBA:GO_Central.
# GO_process	GO:0050951	sensory perception of temperature stimulus; ISS:UniProtKB.
# GO_process	GO:0050976	detection of mechanical stimulus involved in sensory perception of touch; ISS:UniProtKB.
# GO_process	GO:0071260	cellular response to mechanical stimulus; IDA:UniProtKB.
# GO_process	GO:0071398	cellular response to fatty acid; IDA:UniProtKB.
# GO_process	GO:0071469	cellular response to alkaline pH; ISS:UniProtKB.
# GO_process	GO:0071502	cellular response to temperature stimulus; ISS:UniProtKB.
# GO_process	GO:0071805	potassium ion transmembrane transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9NYG8	HS
# HGNC	HGNC:6279	KCNK4
# IntAct	Q9NYG8	2
# InterPro	IPR003280	2pore_dom_K_chnl
# InterPro	IPR008074	2pore_dom_K_chnl_TRAAK
# InterPro	IPR013099	K_chnl_dom
# KEGG_Brite	ko04040	Ion channels
# MIM	605720	gene
# Organism	KCNK4_HUMAN	Homo sapiens (Human)
# PDB	3UM7	X-ray; 3.31 A; A/B=1-274
# PDB	4I9W	X-ray; 2.75 A; A/B=1-274
# PDB	4RUE	X-ray; 3.30 A; A/B=1-274
# PDB	4RUF	X-ray; 3.40 A; A/B=1-274
# PDB	4WFE	X-ray; 2.50 A; A/B=1-264
# PDB	4WFF	X-ray; 2.50 A; A/B=1-264
# PDB	4WFG	X-ray; 3.00 A; A/B=1-264
# PDB	4WFH	X-ray; 3.01 A; A/B=1-264
# PRINTS	PR01333	2POREKCHANEL
# PRINTS	PR01691	TRAAKCHANNEL
# PTM	KCNK4_HUMAN	N-glycosylated. {ECO 0000269|PubMed 22282805}. 
# Pfam	PF07885	Ion_trans_2; 2
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-1299503	TWIK related potassium channel (TREK)
# Reactome	R-HSA-5576886	Phase 4 - resting membrane potential
# RecName	KCNK4_HUMAN	Potassium channel subfamily K member 4
# RefSeq	NP_001304019	NM_001317090.1. [Q9NYG8-1]
# RefSeq	NP_201567	NM_033310.2. [Q9NYG8-1]
# SIMILARITY	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCNK4_HUMAN	Cell membrane {ECO 0000269|PubMed 22282805, ECO 0000269|PubMed 23341632, ECO 0000269|PubMed 25471887, ECO 0000269|PubMed 25500157}; Multi-pass membrane protein {ECO 0000269|PubMed 22282805, ECO 0000269|PubMed 23341632, ECO 0000269|PubMed 25471887, ECO 0000269|PubMed 25500157}. 
# SUBUNIT	KCNK4_HUMAN	Homodimer; disulfide-linked. {ECO 0000269|PubMed 22282805, ECO 0000269|PubMed 23341632, ECO 0000269|PubMed 25471887, ECO 0000269|PubMed 25500157}. 
# UCSC	uc001nzj	human. [Q9NYG8-1]
# eggNOG	COG1226	LUCA
# eggNOG	KOG1418	Eukaryota
BLAST	swissprot:KCNK4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNK4_HUMAN
BioCyc	ZFISH:ENSG00000004469-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000004469-MONOMER
COXPRESdb	50801	http://coxpresdb.jp/data/gene/50801.shtml
CleanEx	HS_KCNK4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNK4
DIP	DIP-61343N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-61343N
DOI	10.1016/S0014-5793(00)01388-0	http://dx.doi.org/10.1016/S0014-5793(00)01388-0
DOI	10.1016/S0169-328X(00)00183-2	http://dx.doi.org/10.1016/S0169-328X(00)00183-2
DOI	10.1016/S0169-328X(02)00157-2	http://dx.doi.org/10.1016/S0169-328X(02)00157-2
DOI	10.1016/j.neuron.2014.11.017	http://dx.doi.org/10.1016/j.neuron.2014.11.017
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1038/nature14013	http://dx.doi.org/10.1038/nature14013
DOI	10.1073/pnas.1218950110	http://dx.doi.org/10.1073/pnas.1218950110
DOI	10.1126/science.1213808	http://dx.doi.org/10.1126/science.1213808
DOI	10.1186/gb-2004-5-2-r8	http://dx.doi.org/10.1186/gb-2004-5-2-r8
EMBL	AF247042	http://www.ebi.ac.uk/ena/data/view/AF247042
EMBL	AF248242	http://www.ebi.ac.uk/ena/data/view/AF248242
EMBL	AF259500	http://www.ebi.ac.uk/ena/data/view/AF259500
EMBL	AF259501	http://www.ebi.ac.uk/ena/data/view/AF259501
EMBL	CH471076	http://www.ebi.ac.uk/ena/data/view/CH471076
EMBL	EU978935	http://www.ebi.ac.uk/ena/data/view/EU978935
Ensembl	ENST00000394525	http://www.ensembl.org/id/ENST00000394525
Ensembl	ENST00000422670	http://www.ensembl.org/id/ENST00000422670
Ensembl	ENST00000539216	http://www.ensembl.org/id/ENST00000539216
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0034705	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034705
GO_function	GO:0005244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005244
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_function	GO:0022841	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022841
GO_function	GO:0097604	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097604
GO_function	GO:0098782	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098782
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0007613	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007613
GO_process	GO:0019233	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019233
GO_process	GO:0030322	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030322
GO_process	GO:0050951	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050951
GO_process	GO:0050976	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050976
GO_process	GO:0071260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071260
GO_process	GO:0071398	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071398
GO_process	GO:0071469	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071469
GO_process	GO:0071502	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071502
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	KCNK4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNK4
GeneID	50801	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=50801
GeneTree	ENSGT00760000118858	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118858
HGNC	HGNC:6279	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6279
HOGENOM	HOG000013106	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000013106&db=HOGENOM6
HOVERGEN	HBG052234	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052234&db=HOVERGEN
HPA	CAB025086	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB025086
InParanoid	Q9NYG8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NYG8
IntAct	Q9NYG8	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NYG8*
InterPro	IPR003280	http://www.ebi.ac.uk/interpro/entry/IPR003280
InterPro	IPR008074	http://www.ebi.ac.uk/interpro/entry/IPR008074
InterPro	IPR013099	http://www.ebi.ac.uk/interpro/entry/IPR013099
Jabion	50801	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=50801
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:50801	http://www.genome.jp/dbget-bin/www_bget?hsa:50801
KEGG_Orthology	KO:K04915	http://www.genome.jp/dbget-bin/www_bget?KO:K04915
MIM	605720	http://www.ncbi.nlm.nih.gov/omim/605720
OMA	LDYPSEN	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LDYPSEN
OrthoDB	EOG091G0E3R	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0E3R
PDB	3UM7	http://www.ebi.ac.uk/pdbe-srv/view/entry/3UM7
PDB	4I9W	http://www.ebi.ac.uk/pdbe-srv/view/entry/4I9W
PDB	4RUE	http://www.ebi.ac.uk/pdbe-srv/view/entry/4RUE
PDB	4RUF	http://www.ebi.ac.uk/pdbe-srv/view/entry/4RUF
PDB	4WFE	http://www.ebi.ac.uk/pdbe-srv/view/entry/4WFE
PDB	4WFF	http://www.ebi.ac.uk/pdbe-srv/view/entry/4WFF
PDB	4WFG	http://www.ebi.ac.uk/pdbe-srv/view/entry/4WFG
PDB	4WFH	http://www.ebi.ac.uk/pdbe-srv/view/entry/4WFH
PDBsum	3UM7	http://www.ebi.ac.uk/pdbsum/3UM7
PDBsum	4I9W	http://www.ebi.ac.uk/pdbsum/4I9W
PDBsum	4RUE	http://www.ebi.ac.uk/pdbsum/4RUE
PDBsum	4RUF	http://www.ebi.ac.uk/pdbsum/4RUF
PDBsum	4WFE	http://www.ebi.ac.uk/pdbsum/4WFE
PDBsum	4WFF	http://www.ebi.ac.uk/pdbsum/4WFF
PDBsum	4WFG	http://www.ebi.ac.uk/pdbsum/4WFG
PDBsum	4WFH	http://www.ebi.ac.uk/pdbsum/4WFH
PRINTS	PR01333	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01333
PRINTS	PR01691	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01691
PSORT	swissprot:KCNK4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNK4_HUMAN
PSORT-B	swissprot:KCNK4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNK4_HUMAN
PSORT2	swissprot:KCNK4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNK4_HUMAN
Pfam	PF07885	http://pfam.xfam.org/family/PF07885
PharmGKB	PA30061	http://www.pharmgkb.org/do/serve?objId=PA30061&objCls=Gene
Phobius	swissprot:KCNK4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNK4_HUMAN
PhylomeDB	Q9NYG8	http://phylomedb.org/?seqid=Q9NYG8
ProteinModelPortal	Q9NYG8	http://www.proteinmodelportal.org/query/uniprot/Q9NYG8
PubMed	10767409	http://www.ncbi.nlm.nih.gov/pubmed/10767409
PubMed	11042359	http://www.ncbi.nlm.nih.gov/pubmed/11042359
PubMed	12191490	http://www.ncbi.nlm.nih.gov/pubmed/12191490
PubMed	14759258	http://www.ncbi.nlm.nih.gov/pubmed/14759258
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	22282805	http://www.ncbi.nlm.nih.gov/pubmed/22282805
PubMed	23341632	http://www.ncbi.nlm.nih.gov/pubmed/23341632
PubMed	25471887	http://www.ncbi.nlm.nih.gov/pubmed/25471887
PubMed	25500157	http://www.ncbi.nlm.nih.gov/pubmed/25500157
Reactome	R-HSA-1299503	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1299503
Reactome	R-HSA-5576886	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576886
RefSeq	NP_001304019	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001304019
RefSeq	NP_201567	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_201567
SMR	Q9NYG8	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9NYG8
STRING	9606.ENSP00000378033	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000378033&targetmode=cogs
UCSC	uc001nzj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001nzj&org=rat
UniGene	Hs.647233	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.647233
UniProtKB	KCNK4_HUMAN	http://www.uniprot.org/uniprot/KCNK4_HUMAN
UniProtKB-AC	Q9NYG8	http://www.uniprot.org/uniprot/Q9NYG8
charge	swissprot:KCNK4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNK4_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG1418	http://eggnogapi.embl.de/nog_data/html/tree/KOG1418
epestfind	swissprot:KCNK4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNK4_HUMAN
garnier	swissprot:KCNK4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNK4_HUMAN
helixturnhelix	swissprot:KCNK4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNK4_HUMAN
hmoment	swissprot:KCNK4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNK4_HUMAN
iep	swissprot:KCNK4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNK4_HUMAN
inforesidue	swissprot:KCNK4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNK4_HUMAN
neXtProt	NX_Q9NYG8	http://www.nextprot.org/db/entry/NX_Q9NYG8
octanol	swissprot:KCNK4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNK4_HUMAN
pepcoil	swissprot:KCNK4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNK4_HUMAN
pepdigest	swissprot:KCNK4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNK4_HUMAN
pepinfo	swissprot:KCNK4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNK4_HUMAN
pepnet	swissprot:KCNK4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNK4_HUMAN
pepstats	swissprot:KCNK4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNK4_HUMAN
pepwheel	swissprot:KCNK4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNK4_HUMAN
pepwindow	swissprot:KCNK4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNK4_HUMAN
sigcleave	swissprot:KCNK4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNK4_HUMAN
## Database	ID	URL or Descriptions
# AltName	CXA1_HUMAN	Connexin-43
# AltName	CXA1_HUMAN	Gap junction 43 kDa heart protein
# BioGrid	108964	41
# CAUTION	CXA1_HUMAN	PubMed 11741837 reported 2 mutations (Phe-11 and Ala-24) linked to non-syndromic autosomal recessive deafness (DFNBG). These mutations have subsequently been shown (PubMed 12457340) to involve the pseudogene of connexin-43 located on chromosome 5. {ECO 0000305|PubMed 12457340}.
# CAUTION	PubMed:7715640 reported a mutation Pro-364 linked to congenital heart diseases. PubMed	8873667 later shown that it is an artifact. {ECO:0000305}. 
# ChiTaRS	GJA1	human
# DISEASE	CXA1_HUMAN	Atrioventricular septal defect 3 (AVSD3) [MIM 600309]  A congenital heart malformation characterized by a common atrioventricular junction coexisting with deficient atrioventricular septation. The complete form involves underdevelopment of the lower part of the atrial septum and the upper part of the ventricular septum; the valve itself is also shared. A less severe form, known as ostium primum atrial septal defect, is characterized by separate atrioventricular valvar orifices despite a common junction. {ECO 0000269|PubMed 11470490}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CXA1_HUMAN	Craniometaphyseal dysplasia, autosomal recessive (CMDR) [MIM 218400]  An osteochondrodysplasia characterized by hyperostosis and sclerosis of the craniofacial bones associated with abnormal modeling of the metaphyses. Sclerosis of the skull may lead to asymmetry of the mandible, as well as to cranial nerve compression, that may finally result in hearing loss and facial palsy. {ECO 0000269|PubMed 23951358}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CXA1_HUMAN	Erythrokeratodermia variabilis (EKV) [MIM 133200]  A genodermatosis characterized by the appearance of two independent skin lesions  transient figurate erythematous patches and hyperkeratosis that is usually localized but occasionally occurs in its generalized form. Clinical presentation varies significantly within a family and from one family to another. Palmoplantar keratoderma is present in around 50% of cases. {ECO 0000269|PubMed 25398053}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CXA1_HUMAN	Hallermann-Streiff syndrome (HSS) [MIM 234100]  A disorder characterized by a typical skull shape (brachycephaly with frontal bossing), hypotrichosis, microphthalmia, cataracts, beaked nose, micrognathia, skin atrophy, dental anomalies and proportionate short stature. Mental retardation is present in a minority of cases. {ECO 0000269|PubMed 14974090}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CXA1_HUMAN	Hypoplastic left heart syndrome 1 (HLHS1) [MIM 241550]  A syndrome due to defective development of the aorta proximal to the entrance of the ductus arteriosus, and hypoplasia of the left ventricle and mitral valve. As a result of the abnormal circulation, the ductus arteriosus and foramen ovale are patent and the right atrium, right ventricle, and pulmonary artery are enlarged. {ECO 0000269|PubMed 11470490}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CXA1_HUMAN	Oculodentodigital dysplasia (ODDD) [MIM 164200]  A disease characterized by a typical facial appearance and variable involvement of the eyes, dentition, and fingers. Characteristic facial features include a narrow, pinched nose with hypoplastic alae nasi, prominent columella and thin anteverted nares together with a narrow nasal bridge, and prominent epicanthic folds giving the impression of hypertelorism. The teeth are usually small and carious. Typical eye findings include microphthalmia and microcornea. The characteristic digital malformation is complete syndactyly of the fourth and fifth fingers (syndactyly type III) but the third finger may be involved and associated camptodactyly is a common finding. Cardiac abnormalities are observed in rare instances. {ECO 0000269|PubMed 12457340, ECO 0000269|PubMed 14729836, ECO 0000269|PubMed 15108203, ECO 0000269|PubMed 15637728, ECO 0000269|PubMed 16219735, ECO 0000269|PubMed 16222672, ECO 0000269|PubMed 16378922, ECO 0000269|PubMed 16709485, ECO 0000269|PubMed 16813608, ECO 0000269|PubMed 16816024, ECO 0000269|PubMed 17509830, ECO 0000269|PubMed 18161618, ECO 0000269|PubMed 19338053, ECO 0000269|PubMed 21670345, ECO 0000269|PubMed 23550541, ECO 0000269|PubMed 24508941}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CXA1_HUMAN	Oculodentodigital dysplasia, autosomal recessive (ODDD- AR) [MIM 257850]  A disease characterized by a typical facial appearance and variable involvement of the eyes, dentition, and fingers. Characteristic facial features include a narrow, pinched nose with hypoplastic alae nasi, prominent columella and thin anteverted nares together with a narrow nasal bridge, and prominent epicanthic folds giving the impression of hypertelorism. The teeth are usually small and carious. Typical eye findings include microphthalmia and microcornea. The characteristic digital malformation is complete syndactyly of the fourth and fifth fingers (syndactyly type III) but the third finger may be involved and associated camptodactyly is a common finding. Cardiac abnormalities are observed in rare instances. {ECO 0000269|PubMed 16816024}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CXA1_HUMAN	Palmoplantar keratoderma and congenital alopecia 1 (PPKCA1) [MIM 104100]  A rare autosomal dominant disorder characterized by severe hyperkeratosis of the palms and soles, and congenital hypotrichosis or alopecia. Dystrophic nail changes occur in some patients. {ECO 0000269|PubMed 25168385}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CXA1_HUMAN	Syndactyly 3 (SDTY3) [MIM 186100]  A form of syndactyly, a congenital anomaly of the hand or foot marked by persistence of the webbing between adjacent digits that are more or less completely attached. In SDTY3, there is usually complete and bilateral syndactyly between the fourth and fifth fingers. Usually it is soft tissue syndactyly but occasionally the distal phalanges are fused. The fifth finger is short with absent or rudimentary middle phalanx. The feet are not affected. {ECO 0000269|PubMed 14729836}. Note=The disease may be caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB01136	Carvedilol
# Ensembl	ENST00000282561	ENSP00000282561; ENSG00000152661
# FUNCTION	CXA1_HUMAN	Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity  acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity). {ECO 0000250|UniProtKB P08050, ECO 0000250|UniProtKB P23242}. 
# GO_component	GO:0000139	Golgi membrane; TAS:Reactome.
# GO_component	GO:0005739	mitochondrion; IDA:AgBase.
# GO_component	GO:0005741	mitochondrial outer membrane; IEA:Ensembl.
# GO_component	GO:0005764	lysosome; IEA:Ensembl.
# GO_component	GO:0005769	early endosome; IEA:Ensembl.
# GO_component	GO:0005771	multivesicular body; IEA:Ensembl.
# GO_component	GO:0005789	endoplasmic reticulum membrane; TAS:Reactome.
# GO_component	GO:0005794	Golgi apparatus; ISS:BHF-UCL.
# GO_component	GO:0005829	cytosol; IEA:Ensembl.
# GO_component	GO:0005882	intermediate filament; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; ISS:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:UniProtKB.
# GO_component	GO:0005916	fascia adherens; IEA:Ensembl.
# GO_component	GO:0005921	gap junction; IDA:BHF-UCL.
# GO_component	GO:0005922	connexin complex; TAS:ProtInc.
# GO_component	GO:0005925	focal adhesion; IDA:UniProtKB.
# GO_component	GO:0014704	intercalated disc; IDA:BHF-UCL.
# GO_component	GO:0016324	apical plasma membrane; IEA:Ensembl.
# GO_component	GO:0016328	lateral plasma membrane; IEA:Ensembl.
# GO_component	GO:0030660	Golgi-associated vesicle membrane; TAS:Reactome.
# GO_component	GO:0043292	contractile fiber; IEA:Ensembl.
# GO_component	GO:0045121	membrane raft; ISS:BHF-UCL.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0004871	signal transducer activity; IMP:UniProtKB.
# GO_function	GO:0005243	gap junction channel activity; IDA:BHF-UCL.
# GO_function	GO:0015075	ion transmembrane transporter activity; IDA:BHF-UCL.
# GO_function	GO:0086075	gap junction channel activity involved in cardiac conduction electrical coupling; NAS:BHF-UCL.
# GO_function	GO:1903763	gap junction channel activity involved in cell communication by electrical coupling; IDA:BHF-UCL.
# GO_process	GO:0001649	osteoblast differentiation; IEA:Ensembl.
# GO_process	GO:0001701	in utero embryonic development; IEA:Ensembl.
# GO_process	GO:0001764	neuron migration; IEA:Ensembl.
# GO_process	GO:0001937	negative regulation of endothelial cell proliferation; IEA:Ensembl.
# GO_process	GO:0001947	heart looping; IEA:Ensembl.
# GO_process	GO:0002070	epithelial cell maturation; IEA:Ensembl.
# GO_process	GO:0002088	lens development in camera-type eye; IEA:Ensembl.
# GO_process	GO:0002544	chronic inflammatory response; IEA:Ensembl.
# GO_process	GO:0003104	positive regulation of glomerular filtration; IEA:Ensembl.
# GO_process	GO:0003158	endothelium development; IEA:Ensembl.
# GO_process	GO:0003294	atrial ventricular junction remodeling; IEA:Ensembl.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006915	apoptotic process; IEA:Ensembl.
# GO_process	GO:0006936	muscle contraction; TAS:ProtInc.
# GO_process	GO:0007165	signal transduction; IDA:BHF-UCL.
# GO_process	GO:0007204	positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
# GO_process	GO:0007267	cell-cell signaling; IDA:BHF-UCL.
# GO_process	GO:0007507	heart development; TAS:ProtInc.
# GO_process	GO:0007512	adult heart development; IEA:Ensembl.
# GO_process	GO:0009268	response to pH; IEA:Ensembl.
# GO_process	GO:0009749	response to glucose; IEA:Ensembl.
# GO_process	GO:0010232	vascular transport; IEA:Ensembl.
# GO_process	GO:0010628	positive regulation of gene expression; IEA:Ensembl.
# GO_process	GO:0010629	negative regulation of gene expression; IEA:Ensembl.
# GO_process	GO:0010643	cell communication by chemical coupling; IEA:Ensembl.
# GO_process	GO:0010644	cell communication by electrical coupling; IDA:BHF-UCL.
# GO_process	GO:0010652	positive regulation of cell communication by chemical coupling; IEA:Ensembl.
# GO_process	GO:0015867	ATP transport; IEA:Ensembl.
# GO_process	GO:0016264	gap junction assembly; TAS:UniProtKB.
# GO_process	GO:0030308	negative regulation of cell growth; ISS:UniProtKB.
# GO_process	GO:0030500	regulation of bone mineralization; IEA:Ensembl.
# GO_process	GO:0032024	positive regulation of insulin secretion; IEA:Ensembl.
# GO_process	GO:0034220	ion transmembrane transport; IDA:BHF-UCL.
# GO_process	GO:0034405	response to fluid shear stress; IEA:Ensembl.
# GO_process	GO:0042733	embryonic digit morphogenesis; IEA:Ensembl.
# GO_process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB.
# GO_process	GO:0043403	skeletal muscle tissue regeneration; IEA:Ensembl.
# GO_process	GO:0043434	response to peptide hormone; IEA:Ensembl.
# GO_process	GO:0045669	positive regulation of osteoblast differentiation; IEA:Ensembl.
# GO_process	GO:0045732	positive regulation of protein catabolic process; IEA:Ensembl.
# GO_process	GO:0045844	positive regulation of striated muscle tissue development; IEA:Ensembl.
# GO_process	GO:0045907	positive regulation of vasoconstriction; IEA:Ensembl.
# GO_process	GO:0045909	positive regulation of vasodilation; IEA:Ensembl.
# GO_process	GO:0046850	regulation of bone remodeling; IEA:Ensembl.
# GO_process	GO:0048514	blood vessel morphogenesis; IEA:Ensembl.
# GO_process	GO:0048812	neuron projection morphogenesis; IEA:Ensembl.
# GO_process	GO:0051259	protein oligomerization; IEA:Ensembl.
# GO_process	GO:0051924	regulation of calcium ion transport; IEA:Ensembl.
# GO_process	GO:0060044	negative regulation of cardiac muscle cell proliferation; IEA:Ensembl.
# GO_process	GO:0060156	milk ejection; IEA:Ensembl.
# GO_process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization; IEA:Ensembl.
# GO_process	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization; IEA:Ensembl.
# GO_process	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization; IEA:Ensembl.
# GO_process	GO:0061045	negative regulation of wound healing; IEA:Ensembl.
# GO_process	GO:0071260	cellular response to mechanical stimulus; IEA:Ensembl.
# GO_process	GO:0086014	atrial cardiac muscle cell action potential; TAS:BHF-UCL.
# GO_process	GO:0086064	cell communication by electrical coupling involved in cardiac conduction; NAS:BHF-UCL.
# GO_process	GO:2000279	negative regulation of DNA biosynthetic process; IEA:Ensembl.
# GO_process	GO:2000810	regulation of bicellular tight junction assembly; IEA:Ensembl.
# GO_process	GO:2000987	positive regulation of behavioral fear response; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005764	lysosome
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0003013	circulatory system process
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0008219	cell death
# GOslim_process	GO:0009790	embryo development
# GOslim_process	GO:0021700	developmental maturation
# GOslim_process	GO:0022607	cellular component assembly
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0034330	cell junction organization
# GOslim_process	GO:0040007	growth
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0048870	cell motility
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P17302	HS
# HGNC	HGNC:4274	GJA1
# INTERACTION	CXA1_HUMAN	Q02487-1 DSC2; NbExp=2; IntAct=EBI-1103439, EBI-6900677; Q07157 TJP1; NbExp=3; IntAct=EBI-1103439, EBI-79553; 
# IntAct	P17302	11
# InterPro	IPR000500	Connexin
# InterPro	IPR002261	Connexin43
# InterPro	IPR013092	Connexin_N
# InterPro	IPR013124	Connexin43_C
# InterPro	IPR017990	Connexin_CS
# InterPro	IPR019570	Connexin_CCC
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Disease	H00449	[Skeletal dysplasia] Oculodentodigital dysplasia
# KEGG_Disease	H00547	[Developmental disorder; Cardiovascular disease] Atrioventricular canal defect
# KEGG_Disease	H00605	[Nervous system disease; Nervous system disease] Deafness, autosomal recessive
# KEGG_Disease	H01095	[Developmental disorder] Syndactyly
# KEGG_Disease	H01272	[Developmental disorder; Cardiovascular disease] Hypoplastic left heart syndrome (HLHS)
# KEGG_Pathway	ko04540	Gap junction
# KEGG_Pathway	ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
# MIM	104100	phenotype
# MIM	121014	gene
# MIM	133200	phenotype
# MIM	164200	phenotype
# MIM	186100	phenotype
# MIM	218400	phenotype
# MIM	234100	phenotype
# MIM	241550	phenotype
# MIM	257850	phenotype
# MIM	600309	phenotype
# Organism	CXA1_HUMAN	Homo sapiens (Human)
# Orphanet	1522	Craniometaphyseal dysplasia
# Orphanet	2248	Hypoplastic left heart syndrome
# Orphanet	2710	Oculodentodigital dysplasia
# Orphanet	90636	Autosomal recessive non-syndromic sensorineural deafness type DFNB
# Orphanet	93404	Syndactyly type 3
# PANTHER	PTHR11984	PTHR11984
# PDB	2LL2	NMR; -; A=234-259
# PIR	A35853	A35853
# PRINTS	PR00206	CONNEXIN
# PRINTS	PR01132	CONNEXINA1
# PROSITE	PS00407	CONNEXINS_1
# PROSITE	PS00408	CONNEXINS_2
# PTM	CXA1_HUMAN	Phosphorylated at Ser-368 by PRKCG; phosphorylation induces disassembly of gap junction plaques and inhibition of gap junction activity (By similarity). Phosphorylation at Ser-325, Ser-328 and Ser-330 by CK1 modulates gap junction assembly. Phosphorylation at Ser-368 by PRKCD triggers its internalization into small vesicles leading to proteasome-mediated degradation (By similarity). {ECO 0000250|UniProtKB P08050, ECO 0000250|UniProtKB Q6TYA7, ECO 0000269|PubMed 12270943, ECO 0000269|PubMed 14702389, ECO 0000269|PubMed 15605363}. 
# PTM	CXA1_HUMAN	S-nitrosylation at Cys-271 is enriched at the muscle endothelial gap junction in arteries, it augments channel permeability and may regulate of smooth muscle cell to endothelial cell communication. 
# PTM	CXA1_HUMAN	Sumoylated with SUMO1, SUMO2 and SUMO3, which may regulate the level of functional Cx43 gap junctions at the plasma membrane. May be desumoylated by SENP1 or SENP2. {ECO 0000269|PubMed 22411987}. 
# Pfam	PF00029	Connexin
# Pfam	PF03508	Connexin43
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-190704	Oligomerization of connexins into connexons
# Reactome	R-HSA-190827	Transport of connexins along the secretory pathway
# Reactome	R-HSA-190840	Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
# Reactome	R-HSA-190861	Gap junction assembly
# Reactome	R-HSA-190873	Gap junction degradation
# Reactome	R-HSA-191647	c-src mediated regulation of Cx43 function and closure of gap junctions
# Reactome	R-HSA-196025	Formation of annular gap junctions
# RecName	CXA1_HUMAN	Gap junction alpha-1 protein
# RefSeq	NP_000156	NM_000165.4
# SIMILARITY	Belongs to the connexin family. Alpha-type (group II) subfamily. {ECO	0000305}. 
# SMART	SM00037	CNX
# SMART	SM01089	Connexin_CCC
# SUBCELLULAR LOCATION	CXA1_HUMAN	Cell membrane {ECO 0000269|PubMed 22411987}; Multi-pass membrane protein {ECO 0000255}. Cell junction, gap junction {ECO 0000269|PubMed 22411987}. Endoplasmic reticulum {ECO 0000250|UniProtKB P23242}. Note=Localizes at the intercalated disk (ICD) in cardiomyocytes and the proper localization at ICD is dependent on TMEM65. {ECO 0000250|UniProtKB P23242}. 
# SUBUNIT	CXA1_HUMAN	A connexon is composed of a hexamer of connexins. Interacts (via C-terminus) with TJP1 (By similarity). Interacts (via C-terminus) with SRC (via SH3 domain) (By similarity). Interacts (not ubiquitinated) with UBQLN4 (via UBA domain) (By similarity). Interacts with SGSM3 and CNST (By similarity). Interacts with RIC1/CIP150. Interacts with CSNK1D. Interacts with NOV (PubMed 15181016, PubMed 15213231). Interacts with TMEM65 (By similarity). {ECO 0000250|UniProtKB P23242, ECO 0000269|PubMed 12270943, ECO 0000269|PubMed 15181016, ECO 0000269|PubMed 15213231, ECO 0000269|PubMed 16112082}. 
# TISSUE SPECIFICITY	Expressed in the heart and fetal cochlea. {ECO:0000269|PubMed	11741837}. 
# UCSC	uc003pyr	human
# eggNOG	ENOG410IF97	Eukaryota
# eggNOG	ENOG4110JTW	LUCA
BLAST	swissprot:CXA1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CXA1_HUMAN
BioCyc	ZFISH:ENSG00000152661-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000152661-MONOMER
COXPRESdb	2697	http://coxpresdb.jp/data/gene/2697.shtml
CleanEx	HS_GJA1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GJA1
DOI	10.1001/archopht.123.10.1422	http://dx.doi.org/10.1001/archopht.123.10.1422
DOI	10.1001/archophthalmol.2011.113	http://dx.doi.org/10.1001/archophthalmol.2011.113
DOI	10.1002/ajmg.a.20614	http://dx.doi.org/10.1002/ajmg.a.20614
DOI	10.1002/ajmg.a.30554	http://dx.doi.org/10.1002/ajmg.a.30554
DOI	10.1002/ajmg.a.30925	http://dx.doi.org/10.1002/ajmg.a.30925
DOI	10.1002/humu.20958	http://dx.doi.org/10.1002/humu.20958
DOI	10.1002/humu.9220	http://dx.doi.org/10.1002/humu.9220
DOI	10.1002/mc.20072	http://dx.doi.org/10.1002/mc.20072
DOI	10.1016/0888-7543(91)90507-B	http://dx.doi.org/10.1016/0888-7543(91)90507-B
DOI	10.1016/S0027-5107(01)00160-9	http://dx.doi.org/10.1016/S0027-5107(01)00160-9
DOI	10.1016/j.bbrc.2005.08.019	http://dx.doi.org/10.1016/j.bbrc.2005.08.019
DOI	10.1016/j.ejmg.2005.05.003	http://dx.doi.org/10.1016/j.ejmg.2005.05.003
DOI	10.1016/j.gene.2014.01.066	http://dx.doi.org/10.1016/j.gene.2014.01.066
DOI	10.1016/j.ijom.2007.03.004	http://dx.doi.org/10.1016/j.ijom.2007.03.004
DOI	10.1038/jid.2014.485	http://dx.doi.org/10.1038/jid.2014.485
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1053/euhj.1999.1718	http://dx.doi.org/10.1053/euhj.1999.1718
DOI	10.1056/NEJM199505183322002	http://dx.doi.org/10.1056/NEJM199505183322002
DOI	10.1074/jbc.273.3.1519	http://dx.doi.org/10.1074/jbc.273.3.1519
DOI	10.1074/jbc.M111.281832	http://dx.doi.org/10.1074/jbc.M111.281832
DOI	10.1074/jbc.M209427200	http://dx.doi.org/10.1074/jbc.M209427200
DOI	10.1074/jbc.M403952200	http://dx.doi.org/10.1074/jbc.M403952200
DOI	10.1074/jbc.M404073200	http://dx.doi.org/10.1074/jbc.M404073200
DOI	10.1080/13816810701538620	http://dx.doi.org/10.1080/13816810701538620
DOI	10.1083/jcb.111.2.589	http://dx.doi.org/10.1083/jcb.111.2.589
DOI	10.1086/346090	http://dx.doi.org/10.1086/346090
DOI	10.1093/hmg/10.25.2945	http://dx.doi.org/10.1093/hmg/10.25.2945
DOI	10.1093/hmg/ddu442	http://dx.doi.org/10.1093/hmg/ddu442
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/cge.12158	http://dx.doi.org/10.1111/cge.12158
DOI	10.1111/j.1399-0004.2006.00631.x	http://dx.doi.org/10.1111/j.1399-0004.2006.00631.x
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1136/jmg.2003.012005	http://dx.doi.org/10.1136/jmg.2003.012005
DOI	10.1136/jmg.2005.037655	http://dx.doi.org/10.1136/jmg.2005.037655
DOI	10.1161/01.CIR.94.8.1909	http://dx.doi.org/10.1161/01.CIR.94.8.1909
DOI	10.1161/01.CIR.97.1.117	http://dx.doi.org/10.1161/01.CIR.97.1.117
DOI	10.1161/01.RES.86.7.723	http://dx.doi.org/10.1161/01.RES.86.7.723
DOI	10.1242/jcs.00889	http://dx.doi.org/10.1242/jcs.00889
DOI	10.1371/journal.pone.0073576	http://dx.doi.org/10.1371/journal.pone.0073576
DrugBank	DB01136	http://www.drugbank.ca/drugs/DB01136
EMBL	AF151980	http://www.ebi.ac.uk/ena/data/view/AF151980
EMBL	AK312324	http://www.ebi.ac.uk/ena/data/view/AK312324
EMBL	AL139098	http://www.ebi.ac.uk/ena/data/view/AL139098
EMBL	BC026329	http://www.ebi.ac.uk/ena/data/view/BC026329
EMBL	CH471051	http://www.ebi.ac.uk/ena/data/view/CH471051
EMBL	CR541660	http://www.ebi.ac.uk/ena/data/view/CR541660
EMBL	M65188	http://www.ebi.ac.uk/ena/data/view/M65188
EMBL	X52947	http://www.ebi.ac.uk/ena/data/view/X52947
Ensembl	ENST00000282561	http://www.ensembl.org/id/ENST00000282561
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005741	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005741
GO_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GO_component	GO:0005769	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005769
GO_component	GO:0005771	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005771
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005882	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005882
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005916	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005916
GO_component	GO:0005921	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005921
GO_component	GO:0005922	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005922
GO_component	GO:0005925	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005925
GO_component	GO:0014704	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014704
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0016328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016328
GO_component	GO:0030660	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030660
GO_component	GO:0043292	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043292
GO_component	GO:0045121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045121
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GO_function	GO:0005243	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005243
GO_function	GO:0015075	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015075
GO_function	GO:0086075	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086075
GO_function	GO:1903763	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903763
GO_process	GO:0001649	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001649
GO_process	GO:0001701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001701
GO_process	GO:0001764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001764
GO_process	GO:0001937	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001937
GO_process	GO:0001947	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001947
GO_process	GO:0002070	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002070
GO_process	GO:0002088	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002088
GO_process	GO:0002544	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002544
GO_process	GO:0003104	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003104
GO_process	GO:0003158	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003158
GO_process	GO:0003294	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003294
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006915	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006915
GO_process	GO:0006936	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006936
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007204
GO_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GO_process	GO:0007507	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007507
GO_process	GO:0007512	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007512
GO_process	GO:0009268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009268
GO_process	GO:0009749	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009749
GO_process	GO:0010232	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010232
GO_process	GO:0010628	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010628
GO_process	GO:0010629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010629
GO_process	GO:0010643	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010643
GO_process	GO:0010644	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010644
GO_process	GO:0010652	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010652
GO_process	GO:0015867	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015867
GO_process	GO:0016264	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016264
GO_process	GO:0030308	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030308
GO_process	GO:0030500	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030500
GO_process	GO:0032024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032024
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0034405	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034405
GO_process	GO:0042733	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042733
GO_process	GO:0043123	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043123
GO_process	GO:0043403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043403
GO_process	GO:0043434	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043434
GO_process	GO:0045669	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045669
GO_process	GO:0045732	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045732
GO_process	GO:0045844	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045844
GO_process	GO:0045907	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045907
GO_process	GO:0045909	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045909
GO_process	GO:0046850	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046850
GO_process	GO:0048514	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048514
GO_process	GO:0048812	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048812
GO_process	GO:0051259	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051259
GO_process	GO:0051924	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051924
GO_process	GO:0060044	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060044
GO_process	GO:0060156	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060156
GO_process	GO:0060307	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060307
GO_process	GO:0060371	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060371
GO_process	GO:0060373	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060373
GO_process	GO:0061045	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061045
GO_process	GO:0071260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071260
GO_process	GO:0086014	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086014
GO_process	GO:0086064	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086064
GO_process	GO:2000279	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000279
GO_process	GO:2000810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000810
GO_process	GO:2000987	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000987
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0003013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003013
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0008219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219
GOslim_process	GO:0009790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009790
GOslim_process	GO:0021700	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021700
GOslim_process	GO:0022607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0034330	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034330
GOslim_process	GO:0040007	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040007
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	GJA1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GJA1
GeneID	2697	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2697
GeneTree	ENSGT00840000129674	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00840000129674
HGNC	HGNC:4274	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4274
HOGENOM	HOG000231127	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231127&db=HOGENOM6
HOVERGEN	HBG009576	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG009576&db=HOVERGEN
HPA	CAB010753	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB010753
HPA	HPA035097	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035097
InParanoid	P17302	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P17302
IntAct	P17302	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P17302*
InterPro	IPR000500	http://www.ebi.ac.uk/interpro/entry/IPR000500
InterPro	IPR002261	http://www.ebi.ac.uk/interpro/entry/IPR002261
InterPro	IPR013092	http://www.ebi.ac.uk/interpro/entry/IPR013092
InterPro	IPR013124	http://www.ebi.ac.uk/interpro/entry/IPR013124
InterPro	IPR017990	http://www.ebi.ac.uk/interpro/entry/IPR017990
InterPro	IPR019570	http://www.ebi.ac.uk/interpro/entry/IPR019570
Jabion	2697	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2697
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Disease	H00449	http://www.genome.jp/dbget-bin/www_bget?H00449
KEGG_Disease	H00547	http://www.genome.jp/dbget-bin/www_bget?H00547
KEGG_Disease	H00605	http://www.genome.jp/dbget-bin/www_bget?H00605
KEGG_Disease	H01095	http://www.genome.jp/dbget-bin/www_bget?H01095
KEGG_Disease	H01272	http://www.genome.jp/dbget-bin/www_bget?H01272
KEGG_Gene	hsa:2697	http://www.genome.jp/dbget-bin/www_bget?hsa:2697
KEGG_Orthology	KO:K07372	http://www.genome.jp/dbget-bin/www_bget?KO:K07372
KEGG_Pathway	ko04540	http://www.genome.jp/kegg-bin/show_pathway?ko04540
KEGG_Pathway	ko05412	http://www.genome.jp/kegg-bin/show_pathway?ko05412
MIM	104100	http://www.ncbi.nlm.nih.gov/omim/104100
MIM	121014	http://www.ncbi.nlm.nih.gov/omim/121014
MIM	133200	http://www.ncbi.nlm.nih.gov/omim/133200
MIM	164200	http://www.ncbi.nlm.nih.gov/omim/164200
MIM	186100	http://www.ncbi.nlm.nih.gov/omim/186100
MIM	218400	http://www.ncbi.nlm.nih.gov/omim/218400
MIM	234100	http://www.ncbi.nlm.nih.gov/omim/234100
MIM	241550	http://www.ncbi.nlm.nih.gov/omim/241550
MIM	257850	http://www.ncbi.nlm.nih.gov/omim/257850
MIM	600309	http://www.ncbi.nlm.nih.gov/omim/600309
MINT	MINT-147603	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-147603
OMA	GANVDMH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GANVDMH
Orphanet	1522	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1522
Orphanet	2248	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=2248
Orphanet	2710	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=2710
Orphanet	90636	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=90636
Orphanet	93404	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=93404
OrthoDB	EOG091G0FKH	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0FKH
PANTHER	PTHR11984	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11984
PDB	2LL2	http://www.ebi.ac.uk/pdbe-srv/view/entry/2LL2
PDBsum	2LL2	http://www.ebi.ac.uk/pdbsum/2LL2
PRINTS	PR00206	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00206
PRINTS	PR01132	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01132
PROSITE	PS00407	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00407
PROSITE	PS00408	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00408
PSORT	swissprot:CXA1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CXA1_HUMAN
PSORT-B	swissprot:CXA1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CXA1_HUMAN
PSORT2	swissprot:CXA1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CXA1_HUMAN
Pfam	PF00029	http://pfam.xfam.org/family/PF00029
Pfam	PF03508	http://pfam.xfam.org/family/PF03508
PharmGKB	PA28685	http://www.pharmgkb.org/do/serve?objId=PA28685&objCls=Gene
Phobius	swissprot:CXA1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CXA1_HUMAN
PhylomeDB	P17302	http://phylomedb.org/?seqid=P17302
ProteinModelPortal	P17302	http://www.proteinmodelportal.org/query/uniprot/P17302
PubMed	10581143	http://www.ncbi.nlm.nih.gov/pubmed/10581143
PubMed	10764404	http://www.ncbi.nlm.nih.gov/pubmed/10764404
PubMed	11470490	http://www.ncbi.nlm.nih.gov/pubmed/11470490
PubMed	11741837	http://www.ncbi.nlm.nih.gov/pubmed/11741837
PubMed	12270943	http://www.ncbi.nlm.nih.gov/pubmed/12270943
PubMed	12457340	http://www.ncbi.nlm.nih.gov/pubmed/12457340
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	14702389	http://www.ncbi.nlm.nih.gov/pubmed/14702389
PubMed	14729836	http://www.ncbi.nlm.nih.gov/pubmed/14729836
PubMed	14974090	http://www.ncbi.nlm.nih.gov/pubmed/14974090
PubMed	15108203	http://www.ncbi.nlm.nih.gov/pubmed/15108203
PubMed	15181016	http://www.ncbi.nlm.nih.gov/pubmed/15181016
PubMed	15213231	http://www.ncbi.nlm.nih.gov/pubmed/15213231
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15605363	http://www.ncbi.nlm.nih.gov/pubmed/15605363
PubMed	15637728	http://www.ncbi.nlm.nih.gov/pubmed/15637728
PubMed	15757815	http://www.ncbi.nlm.nih.gov/pubmed/15757815
PubMed	15978203	http://www.ncbi.nlm.nih.gov/pubmed/15978203
PubMed	16112082	http://www.ncbi.nlm.nih.gov/pubmed/16112082
PubMed	16219735	http://www.ncbi.nlm.nih.gov/pubmed/16219735
PubMed	16222672	http://www.ncbi.nlm.nih.gov/pubmed/16222672
PubMed	16378922	http://www.ncbi.nlm.nih.gov/pubmed/16378922
PubMed	1646158	http://www.ncbi.nlm.nih.gov/pubmed/1646158
PubMed	16709485	http://www.ncbi.nlm.nih.gov/pubmed/16709485
PubMed	16813608	http://www.ncbi.nlm.nih.gov/pubmed/16813608
PubMed	16816024	http://www.ncbi.nlm.nih.gov/pubmed/16816024
PubMed	1696265	http://www.ncbi.nlm.nih.gov/pubmed/1696265
PubMed	17509830	http://www.ncbi.nlm.nih.gov/pubmed/17509830
PubMed	18161618	http://www.ncbi.nlm.nih.gov/pubmed/18161618
PubMed	19338053	http://www.ncbi.nlm.nih.gov/pubmed/19338053
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	21670345	http://www.ncbi.nlm.nih.gov/pubmed/21670345
PubMed	22411987	http://www.ncbi.nlm.nih.gov/pubmed/22411987
PubMed	23550541	http://www.ncbi.nlm.nih.gov/pubmed/23550541
PubMed	23951358	http://www.ncbi.nlm.nih.gov/pubmed/23951358
PubMed	24508941	http://www.ncbi.nlm.nih.gov/pubmed/24508941
PubMed	25168385	http://www.ncbi.nlm.nih.gov/pubmed/25168385
PubMed	25398053	http://www.ncbi.nlm.nih.gov/pubmed/25398053
PubMed	7715640	http://www.ncbi.nlm.nih.gov/pubmed/7715640
PubMed	8873667	http://www.ncbi.nlm.nih.gov/pubmed/8873667
PubMed	9155619	http://www.ncbi.nlm.nih.gov/pubmed/9155619
PubMed	9430691	http://www.ncbi.nlm.nih.gov/pubmed/9430691
PubMed	9443444	http://www.ncbi.nlm.nih.gov/pubmed/9443444
Reactome	R-HSA-190704	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-190704
Reactome	R-HSA-190827	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-190827
Reactome	R-HSA-190840	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-190840
Reactome	R-HSA-190861	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-190861
Reactome	R-HSA-190873	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-190873
Reactome	R-HSA-191647	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-191647
Reactome	R-HSA-196025	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-196025
RefSeq	NP_000156	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000156
SMART	SM00037	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00037
SMART	SM01089	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01089
SMR	P17302	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P17302
STRING	9606.ENSP00000282561	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000282561&targetmode=cogs
UCSC	uc003pyr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003pyr&org=rat
UniGene	Hs.700699	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.700699
UniGene	Hs.74471	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.74471
UniProtKB	CXA1_HUMAN	http://www.uniprot.org/uniprot/CXA1_HUMAN
UniProtKB-AC	P17302	http://www.uniprot.org/uniprot/P17302
charge	swissprot:CXA1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CXA1_HUMAN
eggNOG	ENOG410IF97	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IF97
eggNOG	ENOG4110JTW	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110JTW
epestfind	swissprot:CXA1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CXA1_HUMAN
garnier	swissprot:CXA1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CXA1_HUMAN
helixturnhelix	swissprot:CXA1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CXA1_HUMAN
hmoment	swissprot:CXA1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CXA1_HUMAN
iep	swissprot:CXA1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CXA1_HUMAN
inforesidue	swissprot:CXA1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CXA1_HUMAN
neXtProt	NX_P17302	http://www.nextprot.org/db/entry/NX_P17302
octanol	swissprot:CXA1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CXA1_HUMAN
pepcoil	swissprot:CXA1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CXA1_HUMAN
pepdigest	swissprot:CXA1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CXA1_HUMAN
pepinfo	swissprot:CXA1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CXA1_HUMAN
pepnet	swissprot:CXA1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CXA1_HUMAN
pepstats	swissprot:CXA1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CXA1_HUMAN
pepwheel	swissprot:CXA1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CXA1_HUMAN
pepwindow	swissprot:CXA1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CXA1_HUMAN
sigcleave	swissprot:CXA1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CXA1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ABCG8_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H221-1; Sequence=Displayed; Name=2; IsoId=Q9H221-2; Sequence=VSP_000052; Note=Minor form detected in approximately 10% of the cDNA clones.; 
# AltName	ABCG8_HUMAN	Sterolin-2
# BioGrid	122125	13
# CAUTION	Seems to have a defective ATP-binding region. {ECO	0000305}. 
# CCDS	CCDS1815	-. [Q9H221-1]
# DISEASE	ABCG8_HUMAN	Gallbladder disease 4 (GBD4) [MIM 611465]  One of the major digestive diseases. Gallstones composed of cholesterol (cholelithiasis) are the common manifestations in western countries. Most people with gallstones, however, remain asymptomatic through their lifetimes. {ECO 0000269|PubMed 17632509}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry. 
# DISEASE	ABCG8_HUMAN	Sitosterolemia (STSL) [MIM 210250]  Rare autosomal recessive disorder characterized by increased intestinal absorption of all sterols including cholesterol, plant and shellfish sterols, and decreased biliary excretion of dietary sterols into bile. Sitosterolemia patients have hypercholesterolemia, very high levels of plant sterols in the plasma, and frequently develop tendon and tuberous xanthomas, accelerated atherosclerosis and premature coronary artery disease. {ECO 0000269|PubMed 11099417, ECO 0000269|PubMed 11452359}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00973	Ezetimibe
# Ensembl	ENST00000272286	ENSP00000272286; ENSG00000143921. [Q9H221-1]
# FUNCTION	ABCG8_HUMAN	Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016324	apical plasma membrane; IMP:BHF-UCL.
# GO_component	GO:0043190	ATP-binding cassette (ABC) transporter complex; IDA:BHF-UCL.
# GO_component	GO:0043235	receptor complex; IDA:BHF-UCL.
# GO_function	GO:0005524	ATP binding; IEA:InterPro.
# GO_function	GO:0017127	cholesterol transporter activity; IEA:Ensembl.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; IBA:GO_Central.
# GO_function	GO:0046982	protein heterodimerization activity; IPI:BHF-UCL.
# GO_process	GO:0007584	response to nutrient; IEA:Ensembl.
# GO_process	GO:0007588	excretion; IGI:BHF-UCL.
# GO_process	GO:0010949	negative regulation of intestinal phytosterol absorption; IMP:BHF-UCL.
# GO_process	GO:0015914	phospholipid transport; IEA:Ensembl.
# GO_process	GO:0015918	sterol transport; TAS:Reactome.
# GO_process	GO:0030299	intestinal cholesterol absorption; IC:BHF-UCL.
# GO_process	GO:0033344	cholesterol efflux; IGI:BHF-UCL.
# GO_process	GO:0042493	response to drug; IEA:Ensembl.
# GO_process	GO:0042632	cholesterol homeostasis; IMP:BHF-UCL.
# GO_process	GO:0045796	negative regulation of intestinal cholesterol absorption; IMP:BHF-UCL.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 1.
# Genevisible	Q9H221	HS
# HGNC	HGNC:13887	ABCG8
# INTERACTION	ABCG8_HUMAN	Q9H222 ABCG5; NbExp=2; IntAct=EBI-3908684, EBI-1761423; 
# IntAct	Q9H221	8
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR013525	ABC_2_trans
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Disease	H00152	[Inherited metabolic disease; Cardiovascular disease] Sitosterolemia
# KEGG_Disease	H01213	[Digestive disease] Cholelithiasis
# KEGG_Pathway	ko02010	ABC transporters
# KEGG_Pathway	ko04975	Fat digestion and absorption
# KEGG_Pathway	ko04976	Bile secretion
# MIM	210250	phenotype
# MIM	605460	gene
# MIM	611465	phenotype
# Organism	ABCG8_HUMAN	Homo sapiens (Human)
# Orphanet	2882	Sitosterolemia
# PDB	5DO7	X-ray; 3.93 A; B/D=2-673
# PROSITE	PS00211	ABC_TRANSPORTER_1
# PROSITE	PS50893	ABC_TRANSPORTER_2
# Pfam	PF00005	ABC_tran
# Pfam	PF01061	ABC2_membrane
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-1369062	ABC transporters in lipid homeostasis
# Reactome	R-HSA-265473	Trafficking of dietary sterols
# RecName	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8
# RefSeq	NP_071882	NM_022437.2. [Q9H221-1]
# RefSeq	XP_005264540	XM_005264483.3. [Q9H221-2]
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 ABC transmembrane type-2 domain. {ECO	0000305}. 
# SIMILARITY	Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SUBCELLULAR LOCATION	ABCG8_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUBUNIT	ABCG8_HUMAN	May form heterodimers with ABCG5 or be tightly coupled to ABCG5 along a pathway regulating diatery-sterol absorption and excretion. 
# SUPFAM	SSF52540	SSF52540
# TCDB	3.A.1.204	the atp-binding cassette (abc) superfamily
# TISSUE SPECIFICITY	ABCG8_HUMAN	Strongly expressed in the liver, lower levels in the small intestine and colon. Detectable in a wide variety of human tissues. 
# UCSC	uc002rtq	human. [Q9H221-1]
# WEB RESOURCE	ABCG8_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=Q9H221";
# eggNOG	COG1131	LUCA
# eggNOG	KOG0061	Eukaryota
BLAST	swissprot:ABCG8_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCG8_HUMAN
BioCyc	ZFISH:ENSG00000143921-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000143921-MONOMER
COXPRESdb	64241	http://coxpresdb.jp/data/gene/64241.shtml
CleanEx	HS_ABCG8	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCG8
DIP	DIP-42631N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-42631N
DOI	10.1002/humu.1206	http://dx.doi.org/10.1002/humu.1206
DOI	10.1007/s100380200041	http://dx.doi.org/10.1007/s100380200041
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng2101	http://dx.doi.org/10.1038/ng2101
DOI	10.1086/321294	http://dx.doi.org/10.1086/321294
DOI	10.1126/science.290.5497.1771	http://dx.doi.org/10.1126/science.290.5497.1771
DrugBank	DB00973	http://www.drugbank.ca/drugs/DB00973
EMBL	AC108476	http://www.ebi.ac.uk/ena/data/view/AC108476
EMBL	AF320294	http://www.ebi.ac.uk/ena/data/view/AF320294
EMBL	AF324494	http://www.ebi.ac.uk/ena/data/view/AF324494
EMBL	AF351812	http://www.ebi.ac.uk/ena/data/view/AF351812
EMBL	AF351813	http://www.ebi.ac.uk/ena/data/view/AF351813
EMBL	AF351814	http://www.ebi.ac.uk/ena/data/view/AF351814
EMBL	AF351815	http://www.ebi.ac.uk/ena/data/view/AF351815
EMBL	AF351816	http://www.ebi.ac.uk/ena/data/view/AF351816
EMBL	AF351817	http://www.ebi.ac.uk/ena/data/view/AF351817
EMBL	AF351818	http://www.ebi.ac.uk/ena/data/view/AF351818
EMBL	AF351819	http://www.ebi.ac.uk/ena/data/view/AF351819
EMBL	AF351820	http://www.ebi.ac.uk/ena/data/view/AF351820
EMBL	AF351821	http://www.ebi.ac.uk/ena/data/view/AF351821
EMBL	AF351822	http://www.ebi.ac.uk/ena/data/view/AF351822
EMBL	AF351823	http://www.ebi.ac.uk/ena/data/view/AF351823
EMBL	AF351824	http://www.ebi.ac.uk/ena/data/view/AF351824
Ensembl	ENST00000272286	http://www.ensembl.org/id/ENST00000272286
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0043190	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190
GO_component	GO:0043235	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043235
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0017127	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017127
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GO_function	GO:0046982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046982
GO_process	GO:0007584	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007584
GO_process	GO:0007588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007588
GO_process	GO:0010949	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010949
GO_process	GO:0015914	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015914
GO_process	GO:0015918	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015918
GO_process	GO:0030299	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030299
GO_process	GO:0033344	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033344
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0042632	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042632
GO_process	GO:0045796	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045796
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCG8	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCG8
GeneID	64241	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64241
GeneTree	ENSGT00740000114855	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00740000114855
HGNC	HGNC:13887	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13887
HOGENOM	HOG000033764	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000033764&db=HOGENOM6
HOVERGEN	HBG050444	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050444&db=HOVERGEN
HPA	HPA019556	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA019556
InParanoid	Q9H221	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9H221
IntAct	Q9H221	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9H221*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR013525	http://www.ebi.ac.uk/interpro/entry/IPR013525
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	64241	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=64241
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Disease	H00152	http://www.genome.jp/dbget-bin/www_bget?H00152
KEGG_Disease	H01213	http://www.genome.jp/dbget-bin/www_bget?H01213
KEGG_Gene	hsa:64241	http://www.genome.jp/dbget-bin/www_bget?hsa:64241
KEGG_Orthology	KO:K05684	http://www.genome.jp/dbget-bin/www_bget?KO:K05684
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
KEGG_Pathway	ko04975	http://www.genome.jp/kegg-bin/show_pathway?ko04975
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
MIM	210250	http://www.ncbi.nlm.nih.gov/omim/210250
MIM	605460	http://www.ncbi.nlm.nih.gov/omim/605460
MIM	611465	http://www.ncbi.nlm.nih.gov/omim/611465
MINT	MINT-2840535	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-2840535
OMA	FTYSGQP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FTYSGQP
Orphanet	2882	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=2882
OrthoDB	EOG091G0E38	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0E38
PDB	5DO7	http://www.ebi.ac.uk/pdbe-srv/view/entry/5DO7
PDBsum	5DO7	http://www.ebi.ac.uk/pdbsum/5DO7
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PSORT	swissprot:ABCG8_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCG8_HUMAN
PSORT-B	swissprot:ABCG8_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCG8_HUMAN
PSORT2	swissprot:ABCG8_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCG8_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF01061	http://pfam.xfam.org/family/PF01061
PharmGKB	PA24412	http://www.pharmgkb.org/do/serve?objId=PA24412&objCls=Gene
Phobius	swissprot:ABCG8_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCG8_HUMAN
PhylomeDB	Q9H221	http://phylomedb.org/?seqid=Q9H221
ProteinModelPortal	Q9H221	http://www.proteinmodelportal.org/query/uniprot/Q9H221
PubMed	11099417	http://www.ncbi.nlm.nih.gov/pubmed/11099417
PubMed	11452359	http://www.ncbi.nlm.nih.gov/pubmed/11452359
PubMed	11590207	http://www.ncbi.nlm.nih.gov/pubmed/11590207
PubMed	11668628	http://www.ncbi.nlm.nih.gov/pubmed/11668628
PubMed	12111378	http://www.ncbi.nlm.nih.gov/pubmed/12111378
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	17632509	http://www.ncbi.nlm.nih.gov/pubmed/17632509
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
Reactome	R-HSA-1369062	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1369062
Reactome	R-HSA-265473	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-265473
RefSeq	NP_071882	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_071882
RefSeq	XP_005264540	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005264540
SMR	Q9H221	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9H221
STRING	9606.ENSP00000272286	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000272286&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TCDB	3.A.1.204	http://www.tcdb.org/search/result.php?tc=3.A.1.204
UCSC	uc002rtq	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002rtq&org=rat
UniGene	Hs.413931	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.413931
UniProtKB	ABCG8_HUMAN	http://www.uniprot.org/uniprot/ABCG8_HUMAN
UniProtKB-AC	Q9H221	http://www.uniprot.org/uniprot/Q9H221
charge	swissprot:ABCG8_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCG8_HUMAN
eggNOG	COG1131	http://eggnogapi.embl.de/nog_data/html/tree/COG1131
eggNOG	KOG0061	http://eggnogapi.embl.de/nog_data/html/tree/KOG0061
epestfind	swissprot:ABCG8_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCG8_HUMAN
garnier	swissprot:ABCG8_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCG8_HUMAN
helixturnhelix	swissprot:ABCG8_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCG8_HUMAN
hmoment	swissprot:ABCG8_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCG8_HUMAN
iep	swissprot:ABCG8_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCG8_HUMAN
inforesidue	swissprot:ABCG8_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCG8_HUMAN
neXtProt	NX_Q9H221	http://www.nextprot.org/db/entry/NX_Q9H221
octanol	swissprot:ABCG8_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCG8_HUMAN
pepcoil	swissprot:ABCG8_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCG8_HUMAN
pepdigest	swissprot:ABCG8_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCG8_HUMAN
pepinfo	swissprot:ABCG8_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCG8_HUMAN
pepnet	swissprot:ABCG8_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCG8_HUMAN
pepstats	swissprot:ABCG8_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCG8_HUMAN
pepwheel	swissprot:ABCG8_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCG8_HUMAN
pepwindow	swissprot:ABCG8_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCG8_HUMAN
sigcleave	swissprot:ABCG8_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCG8_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S38A9_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8NBW4-1; Sequence=Displayed; Name=2; IsoId=Q8NBW4-2; Sequence=VSP_032815; Note=No experimental confirmation available.; Name=3; IsoId=Q8NBW4-3; Sequence=VSP_045111, VSP_045112; Name=4; IsoId=Q8NBW4-4; Sequence=VSP_045110; 
# AltName	Solute carrier family 38 member 9 {ECO:0000312|HGNC	HGNC:26907}
# AltName	Up-regulated in lung cancer 11 {ECO	0000303|Ref.2}
# BioGrid	127480	11
# CCDS	CCDS3968	-. [Q8NBW4-1]
# CCDS	CCDS58947	-. [Q8NBW4-4]
# CCDS	CCDS58948	-. [Q8NBW4-3]
# DOMAIN	S38A9_HUMAN	The cytosolic N-terminus part of the protein mediates interaction with the Ragulator complex and the Rag GTPases heterodimers. {ECO 0000269|PubMed 25561175, ECO 0000269|PubMed 25567906}. 
# Ensembl	ENST00000318672	ENSP00000316596; ENSG00000177058. [Q8NBW4-1]
# Ensembl	ENST00000396865	ENSP00000380074; ENSG00000177058. [Q8NBW4-1]
# Ensembl	ENST00000512595	ENSP00000427335; ENSG00000177058. [Q8NBW4-3]
# Ensembl	ENST00000515629	ENSP00000420934; ENSG00000177058. [Q8NBW4-4]
# ExpressionAtlas	Q8NBW4	baseline and differential
# FUNCTION	S38A9_HUMAN	Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acids. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed 25561175, PubMed 25567906). Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids, suggesting that it acts as an amino acid sensor instead (PubMed 25561175, PubMed 25567906). The high concentration of arginine in lysosomes suggests that it acts as an arginine sensor (PubMed 25567906). {ECO 0000269|PubMed 25561175, ECO 0000269|PubMed 25567906}. 
# GO_component	GO:0005764	lysosome; IDA:UniProtKB.
# GO_component	GO:0005765	lysosomal membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005770	late endosome; IDA:UniProtKB.
# GO_component	GO:0005783	endoplasmic reticulum; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0031902	late endosome membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; IDA:UniProtKB.
# GO_process	GO:0003333	amino acid transmembrane transport; IDA:UniProtKB.
# GO_process	GO:0032008	positive regulation of TOR signaling; IDA:UniProtKB.
# GO_process	GO:0071230	cellular response to amino acid stimulus; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005764	lysosome
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q8NBW4	HS
# HGNC	HGNC:26907	SLC38A9
# INTERACTION	S38A9_HUMAN	Q6IAA8 LAMTOR1; NbExp=9; IntAct=EBI-9978316, EBI-715385; Q9UHA4 LAMTOR3; NbExp=5; IntAct=EBI-9978316, EBI-1038192; Q0VGL1 LAMTOR4; NbExp=3; IntAct=EBI-9978316, EBI-5658976; O43504 LAMTOR5; NbExp=3; IntAct=EBI-9978316, EBI-713382; Q7L523 RRAGA; NbExp=11; IntAct=EBI-9978316, EBI-752376; Q9HB90 RRAGC; NbExp=9; IntAct=EBI-9978316, EBI-752390; 
# IntAct	Q8NBW4	15
# InterPro	IPR013057	AA_transpt_TM
# KEGG_Brite	ko02001	Solute carrier family
# MIM	616203	gene
# Organism	S38A9_HUMAN	Homo sapiens (Human)
# PTM	S38A9_HUMAN	Glycosylated. {ECO 0000269|PubMed 25561175, ECO 0000269|PubMed 25567906}. 
# Pfam	PF01490	Aa_trans; 2
# Proteomes	UP000005640	Chromosome 5
# RecName	Sodium-coupled neutral amino acid transporter 9 {ECO	0000305}
# RefSeq	NP_001245215	NM_001258286.1. [Q8NBW4-4]
# RefSeq	NP_001245216	NM_001258287.1. [Q8NBW4-3]
# RefSeq	NP_775785	NM_173514.3. [Q8NBW4-1]
# RefSeq	XP_006714600	XM_006714537.2. [Q8NBW4-1]
# RefSeq	XP_006714601	XM_006714538.3. [Q8NBW4-1]
# RefSeq	XP_006714602	XM_006714539.3. [Q8NBW4-1]
# RefSeq	XP_011541475	XM_011543173.1. [Q8NBW4-1]
# RefSeq	XP_011541476	XM_011543174.1. [Q8NBW4-1]
# SEQUENCE CAUTION	Sequence=BAQ19756.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the amino acid/polyamine transporter 2 family. SLC38A9 subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S38A9_HUMAN	Lysosome membrane {ECO 0000269|PubMed 25561175, ECO 0000269|PubMed 25567906}; Multi- pass membrane protein {ECO 0000255}. Late endosome membrane {ECO 0000269|PubMed 25561175}; Multi-pass membrane protein {ECO 0000255}. 
# SUBUNIT	S38A9_HUMAN	Associated component of the Ragulator complex (composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5). Associated component of the Rag GTPases heterodimers (composed of RRAGA, RRAGB, RRAGC and RRAGD). {ECO 0000269|PubMed 25561175, ECO 0000269|PubMed 25567906}. 
# TCDB	2.A.18.9	the amino acid/auxin permease (aaap) family
# UCSC	uc003jqd	human. [Q8NBW4-1]
# eggNOG	COG0814	LUCA
# eggNOG	KOG1305	Eukaryota
BLAST	swissprot:S38A9_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S38A9_HUMAN
BioCyc	ZFISH:ENSG00000177058-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000177058-MONOMER
COXPRESdb	153129	http://coxpresdb.jp/data/gene/153129.shtml
CleanEx	HS_SLC38A9	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC38A9
DIP	DIP-61480N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-61480N
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1038/nature14107	http://dx.doi.org/10.1038/nature14107
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1257132	http://dx.doi.org/10.1126/science.1257132
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AB105188	http://www.ebi.ac.uk/ena/data/view/AB105188
EMBL	AC008784	http://www.ebi.ac.uk/ena/data/view/AC008784
EMBL	AC016632	http://www.ebi.ac.uk/ena/data/view/AC016632
EMBL	AK075190	http://www.ebi.ac.uk/ena/data/view/AK075190
EMBL	AK127988	http://www.ebi.ac.uk/ena/data/view/AK127988
EMBL	AK301850	http://www.ebi.ac.uk/ena/data/view/AK301850
EMBL	BC066891	http://www.ebi.ac.uk/ena/data/view/BC066891
EMBL	BC101362	http://www.ebi.ac.uk/ena/data/view/BC101362
EMBL	BX641065	http://www.ebi.ac.uk/ena/data/view/BX641065
EMBL	CH471123	http://www.ebi.ac.uk/ena/data/view/CH471123
Ensembl	ENST00000318672	http://www.ensembl.org/id/ENST00000318672
Ensembl	ENST00000396865	http://www.ensembl.org/id/ENST00000396865
Ensembl	ENST00000512595	http://www.ensembl.org/id/ENST00000512595
Ensembl	ENST00000515629	http://www.ensembl.org/id/ENST00000515629
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005770	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005770
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0031902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031902
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_process	GO:0003333	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003333
GO_process	GO:0032008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032008
GO_process	GO:0071230	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071230
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC38A9	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC38A9
GeneID	153129	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=153129
GeneTree	ENSGT00390000005646	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000005646
HGNC	HGNC:26907	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:26907
HOGENOM	HOG000294102	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294102&db=HOGENOM6
HOVERGEN	HBG106242	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG106242&db=HOVERGEN
HPA	HPA043785	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA043785
InParanoid	Q8NBW4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8NBW4
IntAct	Q8NBW4	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8NBW4*
InterPro	IPR013057	http://www.ebi.ac.uk/interpro/entry/IPR013057
Jabion	153129	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=153129
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:153129	http://www.genome.jp/dbget-bin/www_bget?hsa:153129
KEGG_Orthology	KO:K14995	http://www.genome.jp/dbget-bin/www_bget?KO:K14995
MIM	616203	http://www.ncbi.nlm.nih.gov/omim/616203
OMA	DCIEQNF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DCIEQNF
OrthoDB	EOG091G04X6	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G04X6
PSORT	swissprot:S38A9_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S38A9_HUMAN
PSORT-B	swissprot:S38A9_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S38A9_HUMAN
PSORT2	swissprot:S38A9_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S38A9_HUMAN
Pfam	PF01490	http://pfam.xfam.org/family/PF01490
PharmGKB	PA162403774	http://www.pharmgkb.org/do/serve?objId=PA162403774&objCls=Gene
Phobius	swissprot:S38A9_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S38A9_HUMAN
PhylomeDB	Q8NBW4	http://phylomedb.org/?seqid=Q8NBW4
ProteinModelPortal	Q8NBW4	http://www.proteinmodelportal.org/query/uniprot/Q8NBW4
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	25561175	http://www.ncbi.nlm.nih.gov/pubmed/25561175
PubMed	25567906	http://www.ncbi.nlm.nih.gov/pubmed/25567906
RefSeq	NP_001245215	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001245215
RefSeq	NP_001245216	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001245216
RefSeq	NP_775785	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_775785
RefSeq	XP_006714600	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006714600
RefSeq	XP_006714601	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006714601
RefSeq	XP_006714602	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006714602
RefSeq	XP_011541475	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011541475
RefSeq	XP_011541476	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011541476
STRING	9606.ENSP00000316596	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000316596&targetmode=cogs
TCDB	2.A.18.9	http://www.tcdb.org/search/result.php?tc=2.A.18.9
UCSC	uc003jqd	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003jqd&org=rat
UniGene	Hs.742101	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.742101
UniGene	Hs.745105	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.745105
UniProtKB	S38A9_HUMAN	http://www.uniprot.org/uniprot/S38A9_HUMAN
UniProtKB-AC	Q8NBW4	http://www.uniprot.org/uniprot/Q8NBW4
charge	swissprot:S38A9_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S38A9_HUMAN
eggNOG	COG0814	http://eggnogapi.embl.de/nog_data/html/tree/COG0814
eggNOG	KOG1305	http://eggnogapi.embl.de/nog_data/html/tree/KOG1305
epestfind	swissprot:S38A9_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S38A9_HUMAN
garnier	swissprot:S38A9_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S38A9_HUMAN
helixturnhelix	swissprot:S38A9_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S38A9_HUMAN
hmoment	swissprot:S38A9_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S38A9_HUMAN
iep	swissprot:S38A9_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S38A9_HUMAN
inforesidue	swissprot:S38A9_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S38A9_HUMAN
neXtProt	NX_Q8NBW4	http://www.nextprot.org/db/entry/NX_Q8NBW4
octanol	swissprot:S38A9_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S38A9_HUMAN
pepcoil	swissprot:S38A9_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S38A9_HUMAN
pepdigest	swissprot:S38A9_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S38A9_HUMAN
pepinfo	swissprot:S38A9_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S38A9_HUMAN
pepnet	swissprot:S38A9_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S38A9_HUMAN
pepstats	swissprot:S38A9_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S38A9_HUMAN
pepwheel	swissprot:S38A9_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S38A9_HUMAN
pepwindow	swissprot:S38A9_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S38A9_HUMAN
sigcleave	swissprot:S38A9_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S38A9_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ANO1_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5XXA6-1; Sequence=Displayed; Name=2; IsoId=Q5XXA6-2; Sequence=VSP_025665, VSP_025668, VSP_025669; Note=No experimental confirmation available.; Name=3; IsoId=Q5XXA6-3; Sequence=VSP_025666, VSP_025667, VSP_025668, VSP_025669, VSP_025670, VSP_025671; Note=No experimental confirmation available.; 
# AltName	ANO1_HUMAN	Discovered on gastrointestinal stromal tumors protein 1
# AltName	ANO1_HUMAN	Oral cancer overexpressed protein 2
# AltName	ANO1_HUMAN	Transmembrane protein 16A
# AltName	ANO1_HUMAN	Tumor-amplified and overexpressed sequence 2
# CCDS	CCDS44663	-. [Q5XXA6-1]
# ChiTaRS	ANO1	human
# DOMAIN	ANO1_HUMAN	The region spanning the fifth and sixth transmembrane domains probably forms the pore-forming region. {ECO 0000250}. 
# DrugBank	DB04941	Crofelemer
# ENZYME REGULATION	ATP and calmodulin are essential for its activation. Channel activity is inhibited by CFTR protein and by chloride inhibitors such as niflumic acid (NFA) and 4,4'- diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS). {ECO:0000269|PubMed	22178883}. 
# Ensembl	ENST00000316296	ENSP00000319477; ENSG00000131620. [Q5XXA6-3]
# Ensembl	ENST00000355303	ENSP00000347454; ENSG00000131620. [Q5XXA6-1]
# Ensembl	ENST00000530676	ENSP00000435797; ENSG00000131620. [Q5XXA6-2]
# ExpressionAtlas	Q5XXA6	baseline and differential
# FUNCTION	ANO1_HUMAN	Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. {ECO 0000269|PubMed 20056604, ECO 0000269|PubMed 21984732, ECO 0000269|PubMed 22178883, ECO 0000269|PubMed 22946059}. 
# GO_component	GO:0005737	cytoplasm; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005227	calcium activated cation channel activity; IDA:UniProtKB.
# GO_function	GO:0005229	intracellular calcium activated chloride channel activity; IDA:UniProtKB.
# GO_function	GO:0005247	voltage-gated chloride channel activity; ISS:UniProtKB.
# GO_function	GO:0005254	chloride channel activity; IMP:UniProtKB.
# GO_function	GO:0015111	iodide transmembrane transporter activity; IMP:UniProtKB.
# GO_process	GO:0006812	cation transport; IDA:UniProtKB.
# GO_process	GO:0006821	chloride transport; IMP:UniProtKB.
# GO_process	GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway; ISS:UniProtKB.
# GO_process	GO:0007275	multicellular organism development; IEA:UniProtKB-KW.
# GO_process	GO:0015705	iodide transport; IMP:UniProtKB.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0034605	cellular response to heat; ISS:UniProtKB.
# GO_process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus; IMP:UniProtKB.
# GO_process	GO:0050965	detection of temperature stimulus involved in sensory perception of pain; ISS:UniProtKB.
# GO_process	GO:1902476	chloride transmembrane transport; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q5XXA6	HS
# HGNC	HGNC:21625	ANO1
# InterPro	IPR007632	Anoctamin
# InterPro	IPR031287	Anoctamin-1
# InterPro	IPR032394	Anoct_dimer
# MIM	610108	gene
# MISCELLANEOUS	ANO1_HUMAN	The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology. 
# Organism	ANO1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12308	PTHR12308; 2
# PANTHER	PTHR12308:SF13	PTHR12308:SF13; 2
# Pfam	PF04547	Anoctamin
# Pfam	PF16178	Anoct_dimer
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	ANO1_HUMAN	Anoctamin-1
# RefSeq	NP_060513	NM_018043.5. [Q5XXA6-1]
# RefSeq	XP_006718668	XM_006718605.2. [Q5XXA6-2]
# RefSeq	XP_011543433	XM_011545131.2. [Q5XXA6-3]
# SIMILARITY	Belongs to the anoctamin family. {ECO	0000305}.
# SUBCELLULAR LOCATION	ANO1_HUMAN	Cell membrane {ECO 0000269|PubMed 15215166, ECO 0000269|PubMed 20056604, ECO 0000269|PubMed 21984732, ECO 0000269|PubMed 22178883, ECO 0000269|PubMed 22946059}; Multi- pass membrane protein {ECO 0000255}. Cytoplasm {ECO 0000269|PubMed 16261155}. Note=Cytoplasmic localization seen in neoplastic cells of head and neck squamous cell carcinoma (HNSCC) tumors. {ECO 0000269|PubMed 16261155}. 
# SUBUNIT	ANO1_HUMAN	Homodimer (PubMed 21056985). Interacts with CFTR (PubMed 22178883). Interacts with TRPV4 (By similarity). {ECO 0000250|UniProtKB Q8BHY3, ECO 0000269|PubMed 21056985, ECO 0000269|PubMed 22178883}. 
# TCDB	1.A.17.1	the calcium-dependent chloride channel (ca-clc) family
# TISSUE SPECIFICITY	ANO1_HUMAN	Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles. {ECO 0000269|PubMed 15215166, ECO 0000269|PubMed 16906560}. 
# UCSC	uc001opj	human. [Q5XXA6-1]
# eggNOG	ENOG410XS4S	LUCA
# eggNOG	KOG2514	Eukaryota
BLAST	swissprot:ANO1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ANO1_HUMAN
COXPRESdb	55107	http://coxpresdb.jp/data/gene/55107.shtml
CleanEx	HS_ANO1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ANO1
DOI	10.1002/gcc.20371	http://dx.doi.org/10.1002/gcc.20371
DOI	10.1007/s00424-011-0975-9	http://dx.doi.org/10.1007/s00424-011-0975-9
DOI	10.1016/S0002-9440(10)63279-8	http://dx.doi.org/10.1016/S0002-9440(10)63279-8
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/aps.2011.48	http://dx.doi.org/10.1038/aps.2011.48
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.onc.1209203	http://dx.doi.org/10.1038/sj.onc.1209203
DOI	10.1074/jbc.M109.065367	http://dx.doi.org/10.1074/jbc.M109.065367
DOI	10.1074/jbc.M110.174847	http://dx.doi.org/10.1074/jbc.M110.174847
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1113/expphysiol.2011.058198	http://dx.doi.org/10.1113/expphysiol.2011.058198
DOI	10.1113/expphysiol.2011.058206	http://dx.doi.org/10.1113/expphysiol.2011.058206
DOI	10.1113/expphysiol.2011.058214	http://dx.doi.org/10.1113/expphysiol.2011.058214
DOI	10.1152/physiol.00030.2010	http://dx.doi.org/10.1152/physiol.00030.2010
DOI	10.1159/000335765	http://dx.doi.org/10.1159/000335765
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1242/jcs.109553	http://dx.doi.org/10.1242/jcs.109553
DrugBank	DB04941	http://www.drugbank.ca/drugs/DB04941
EMBL	AK097619	http://www.ebi.ac.uk/ena/data/view/AK097619
EMBL	AK293088	http://www.ebi.ac.uk/ena/data/view/AK293088
EMBL	AY728143	http://www.ebi.ac.uk/ena/data/view/AY728143
EMBL	BC033036	http://www.ebi.ac.uk/ena/data/view/BC033036
Ensembl	ENST00000316296	http://www.ensembl.org/id/ENST00000316296
Ensembl	ENST00000355303	http://www.ensembl.org/id/ENST00000355303
Ensembl	ENST00000530676	http://www.ensembl.org/id/ENST00000530676
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005227	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005227
GO_function	GO:0005229	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005229
GO_function	GO:0005247	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005247
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0015111	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015111
GO_process	GO:0006812	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006812
GO_process	GO:0006821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006821
GO_process	GO:0007200	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007200
GO_process	GO:0007275	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007275
GO_process	GO:0015705	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015705
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0034605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034605
GO_process	GO:0035774	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035774
GO_process	GO:0050965	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050965
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ANO1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ANO1
GeneID	55107	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55107
GeneTree	ENSGT00760000119015	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119015
HGNC	HGNC:21625	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:21625
HOGENOM	HOG000006509	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006509&db=HOGENOM6
HOVERGEN	HBG069519	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG069519&db=HOVERGEN
HPA	HPA032148	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA032148
InParanoid	Q5XXA6	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q5XXA6
IntAct	Q5XXA6	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q5XXA6*
InterPro	IPR007632	http://www.ebi.ac.uk/interpro/entry/IPR007632
InterPro	IPR031287	http://www.ebi.ac.uk/interpro/entry/IPR031287
InterPro	IPR032394	http://www.ebi.ac.uk/interpro/entry/IPR032394
Jabion	55107	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55107
KEGG_Gene	hsa:55107	http://www.genome.jp/dbget-bin/www_bget?hsa:55107
MIM	610108	http://www.ncbi.nlm.nih.gov/omim/610108
OMA	DPDAECK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DPDAECK
OrthoDB	EOG091G01JF	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01JF
PANTHER	PTHR12308	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12308
PANTHER	PTHR12308:SF13	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12308:SF13
PSORT	swissprot:ANO1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ANO1_HUMAN
PSORT-B	swissprot:ANO1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ANO1_HUMAN
PSORT2	swissprot:ANO1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ANO1_HUMAN
Pfam	PF04547	http://pfam.xfam.org/family/PF04547
Pfam	PF16178	http://pfam.xfam.org/family/PF16178
PharmGKB	PA164715378	http://www.pharmgkb.org/do/serve?objId=PA164715378&objCls=Gene
Phobius	swissprot:ANO1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ANO1_HUMAN
PhylomeDB	Q5XXA6	http://phylomedb.org/?seqid=Q5XXA6
ProteinModelPortal	Q5XXA6	http://www.proteinmodelportal.org/query/uniprot/Q5XXA6
PubMed	12739008	http://www.ncbi.nlm.nih.gov/pubmed/12739008
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15215166	http://www.ncbi.nlm.nih.gov/pubmed/15215166
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16261155	http://www.ncbi.nlm.nih.gov/pubmed/16261155
PubMed	16906560	http://www.ncbi.nlm.nih.gov/pubmed/16906560
PubMed	20056604	http://www.ncbi.nlm.nih.gov/pubmed/20056604
PubMed	21056985	http://www.ncbi.nlm.nih.gov/pubmed/21056985
PubMed	21186280	http://www.ncbi.nlm.nih.gov/pubmed/21186280
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21607626	http://www.ncbi.nlm.nih.gov/pubmed/21607626
PubMed	21642943	http://www.ncbi.nlm.nih.gov/pubmed/21642943
PubMed	21908539	http://www.ncbi.nlm.nih.gov/pubmed/21908539
PubMed	21984732	http://www.ncbi.nlm.nih.gov/pubmed/21984732
PubMed	22178883	http://www.ncbi.nlm.nih.gov/pubmed/22178883
PubMed	22302790	http://www.ncbi.nlm.nih.gov/pubmed/22302790
PubMed	22946059	http://www.ncbi.nlm.nih.gov/pubmed/22946059
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_060513	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060513
RefSeq	XP_006718668	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006718668
RefSeq	XP_011543433	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011543433
STRING	9606.ENSP00000347454	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000347454&targetmode=cogs
TCDB	1.A.17.1	http://www.tcdb.org/search/result.php?tc=1.A.17.1
UCSC	uc001opj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001opj&org=rat
UniGene	Hs.503074	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.503074
UniProtKB	ANO1_HUMAN	http://www.uniprot.org/uniprot/ANO1_HUMAN
UniProtKB-AC	Q5XXA6	http://www.uniprot.org/uniprot/Q5XXA6
charge	swissprot:ANO1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ANO1_HUMAN
eggNOG	ENOG410XS4S	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS4S
eggNOG	KOG2514	http://eggnogapi.embl.de/nog_data/html/tree/KOG2514
epestfind	swissprot:ANO1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ANO1_HUMAN
garnier	swissprot:ANO1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ANO1_HUMAN
helixturnhelix	swissprot:ANO1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ANO1_HUMAN
hmoment	swissprot:ANO1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ANO1_HUMAN
iep	swissprot:ANO1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ANO1_HUMAN
inforesidue	swissprot:ANO1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ANO1_HUMAN
neXtProt	NX_Q5XXA6	http://www.nextprot.org/db/entry/NX_Q5XXA6
octanol	swissprot:ANO1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ANO1_HUMAN
pepcoil	swissprot:ANO1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ANO1_HUMAN
pepdigest	swissprot:ANO1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ANO1_HUMAN
pepinfo	swissprot:ANO1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ANO1_HUMAN
pepnet	swissprot:ANO1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ANO1_HUMAN
pepstats	swissprot:ANO1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ANO1_HUMAN
pepwheel	swissprot:ANO1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ANO1_HUMAN
pepwindow	swissprot:ANO1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ANO1_HUMAN
sigcleave	swissprot:ANO1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ANO1_HUMAN
## Database	ID	URL or Descriptions
# AltName	S18B1_HUMAN	Solute carrier family 18 member B1
# CDD	cd06174	MFS
# Ensembl	ENST00000275227	ENSP00000275227; ENSG00000146409
# ExpressionAtlas	Q6NT16	baseline and differential
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0022857	transmembrane transporter activity; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# Genevisible	Q6NT16	HS
# HGNC	HGNC:21573	SLC18B1
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# MIM	613361	gene
# Organism	S18B1_HUMAN	Homo sapiens (Human)
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1; 2
# Proteomes	UP000005640	Chromosome 6
# RecName	S18B1_HUMAN	MFS-type transporter SLC18B1
# RefSeq	NP_439896	NM_052831.2
# SIMILARITY	Belongs to the major facilitator superfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	S18B1_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.2.57	the major facilitator superfamily (mfs)
# UCSC	uc003qdw	human
# eggNOG	ENOG410INZN	Eukaryota
# eggNOG	ENOG410XYVZ	LUCA
BLAST	swissprot:S18B1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S18B1_HUMAN
BioCyc	ZFISH:G66-30996-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-30996-MONOMER
COXPRESdb	116843	http://coxpresdb.jp/data/gene/116843.shtml
CleanEx	HS_C6orf192	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_C6orf192
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AK124442	http://www.ebi.ac.uk/ena/data/view/AK124442
EMBL	AK289918	http://www.ebi.ac.uk/ena/data/view/AK289918
EMBL	AL032821	http://www.ebi.ac.uk/ena/data/view/AL032821
EMBL	AL032821	http://www.ebi.ac.uk/ena/data/view/AL032821
EMBL	AL137783	http://www.ebi.ac.uk/ena/data/view/AL137783
EMBL	AL137783	http://www.ebi.ac.uk/ena/data/view/AL137783
EMBL	BC069567	http://www.ebi.ac.uk/ena/data/view/BC069567
EMBL	BC069570	http://www.ebi.ac.uk/ena/data/view/BC069570
EMBL	CH471051	http://www.ebi.ac.uk/ena/data/view/CH471051
Ensembl	ENST00000275227	http://www.ensembl.org/id/ENST00000275227
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GeneCards	SLC18B1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC18B1
GeneID	116843	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=116843
GeneTree	ENSGT00390000003851	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000003851
HGNC	HGNC:21573	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:21573
HOGENOM	HOG000007824	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007824&db=HOGENOM6
HOVERGEN	HBG054469	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054469&db=HOVERGEN
HPA	HPA029747	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA029747
HPA	HPA049659	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA049659
InParanoid	Q6NT16	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6NT16
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	116843	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=116843
KEGG_Gene	hsa:116843	http://www.genome.jp/dbget-bin/www_bget?hsa:116843
MIM	613361	http://www.ncbi.nlm.nih.gov/omim/613361
OMA	RIGAKFM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RIGAKFM
OrthoDB	EOG091G07C8	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07C8
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:S18B1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S18B1_HUMAN
PSORT-B	swissprot:S18B1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S18B1_HUMAN
PSORT2	swissprot:S18B1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S18B1_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA134992727	http://www.pharmgkb.org/do/serve?objId=PA134992727&objCls=Gene
Phobius	swissprot:S18B1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S18B1_HUMAN
PhylomeDB	Q6NT16	http://phylomedb.org/?seqid=Q6NT16
ProteinModelPortal	Q6NT16	http://www.proteinmodelportal.org/query/uniprot/Q6NT16
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
RefSeq	NP_439896	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_439896
STRING	9606.ENSP00000275227	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000275227&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.2.57	http://www.tcdb.org/search/result.php?tc=2.A.1.2.57
UCSC	uc003qdw	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003qdw&org=rat
UniGene	Hs.347144	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.347144
UniProtKB	S18B1_HUMAN	http://www.uniprot.org/uniprot/S18B1_HUMAN
UniProtKB-AC	Q6NT16	http://www.uniprot.org/uniprot/Q6NT16
charge	swissprot:S18B1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S18B1_HUMAN
eggNOG	ENOG410INZN	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410INZN
eggNOG	ENOG410XYVZ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XYVZ
epestfind	swissprot:S18B1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S18B1_HUMAN
garnier	swissprot:S18B1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S18B1_HUMAN
helixturnhelix	swissprot:S18B1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S18B1_HUMAN
hmoment	swissprot:S18B1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S18B1_HUMAN
iep	swissprot:S18B1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S18B1_HUMAN
inforesidue	swissprot:S18B1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S18B1_HUMAN
neXtProt	NX_Q6NT16	http://www.nextprot.org/db/entry/NX_Q6NT16
octanol	swissprot:S18B1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S18B1_HUMAN
pepcoil	swissprot:S18B1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S18B1_HUMAN
pepdigest	swissprot:S18B1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S18B1_HUMAN
pepinfo	swissprot:S18B1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S18B1_HUMAN
pepnet	swissprot:S18B1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S18B1_HUMAN
pepstats	swissprot:S18B1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S18B1_HUMAN
pepwheel	swissprot:S18B1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S18B1_HUMAN
pepwindow	swissprot:S18B1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S18B1_HUMAN
sigcleave	swissprot:S18B1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S18B1_HUMAN
## Database	ID	URL or Descriptions
# AltName	AT135_HUMAN	P5-ATPase isoform 5
# CATALYTIC ACTIVITY	AT135_HUMAN	ATP + H(2)O = ADP + phosphate. 
# Ensembl	ENST00000342358	ENSP00000341942; ENSG00000187527
# ExpressionAtlas	Q4VNC0	baseline and differential
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IBA:GO_Central.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0019829	cation-transporting ATPase activity; IBA:GO_Central.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0006874	cellular calcium ion homeostasis; IBA:GO_Central.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.70.150.10	-; 1.
# Gene3D	3.40.1110.10	-; 1.
# Gene3D	3.40.50.1000	-; 2.
# Genevisible	Q4VNC0	HS
# HGNC	HGNC:31789	ATP13A5
# InterPro	IPR001757	P_typ_ATPase
# InterPro	IPR004014	ATPase_P-typ_cation-transptr_N
# InterPro	IPR006544	P-type_TPase_V
# InterPro	IPR008250	ATPase_P-typ_transduc_dom_A
# InterPro	IPR018303	ATPase_P-typ_P_site
# InterPro	IPR023214	HAD-like_dom
# InterPro	IPR023299	ATPase_P-typ_cyto_domN
# KEGG_Brite	ko01000	Enzymes
# Organism	AT135_HUMAN	Homo sapiens (Human)
# PROSITE	PS00154	ATPASE_E1_E2
# Pfam	PF00122	E1-E2_ATPase
# Pfam	PF00690	Cation_ATPase_N
# Pfam	PF12409	P5-ATPase
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	AT135_HUMAN	Probable cation-transporting ATPase 13A5
# RefSeq	NP_940907	NM_198505.2
# SEQUENCE CAUTION	Sequence=AAQ89030.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAQ89030.1; Type=Frameshift; Positions=1126, 1135; Evidence={ECO	0000305}; Sequence=BAC85490.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Cloning artifact.; Evidence={ECO:0000305};
# SIMILARITY	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	AT135_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF56784	SSF56784; 3
# SUPFAM	SSF81660	SSF81660
# TIGRFAMs	TIGR01494	ATPase_P-type
# TIGRFAMs	TIGR01657	P-ATPase-V
# UCSC	uc011bsq	human
# eggNOG	ENOG410XRCA	LUCA
# eggNOG	KOG0208	Eukaryota
BLAST	swissprot:AT135_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AT135_HUMAN
COXPRESdb	344905	http://coxpresdb.jp/data/gene/344905.shtml
CleanEx	HS_ATP13A5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP13A5
DOI	10.1016/j.ygeno.2005.04.002	http://dx.doi.org/10.1016/j.ygeno.2005.04.002
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
EC_number	EC:3.6.3.-	http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.-
EMBL	AK122613	http://www.ebi.ac.uk/ena/data/view/AK122613
EMBL	AY358667	http://www.ebi.ac.uk/ena/data/view/AY358667
EMBL	AY823163	http://www.ebi.ac.uk/ena/data/view/AY823163
ENZYME	3.6.3.-	http://enzyme.expasy.org/EC/3.6.3.-
Ensembl	ENST00000342358	http://www.ensembl.org/id/ENST00000342358
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0019829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019829
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.70.150.10	http://www.cathdb.info/version/latest/superfamily/2.70.150.10
Gene3D	3.40.1110.10	http://www.cathdb.info/version/latest/superfamily/3.40.1110.10
Gene3D	3.40.50.1000	http://www.cathdb.info/version/latest/superfamily/3.40.50.1000
GeneCards	ATP13A5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP13A5
GeneID	344905	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=344905
GeneTree	ENSGT00530000063001	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063001
HGNC	HGNC:31789	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:31789
HOGENOM	HOG000171813	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000171813&db=HOGENOM6
HOVERGEN	HBG065757	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG065757&db=HOVERGEN
HPA	HPA031771	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031771
HPA	HPA031774	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031774
InParanoid	Q4VNC0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q4VNC0
IntEnz	3.6.3	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3
InterPro	IPR001757	http://www.ebi.ac.uk/interpro/entry/IPR001757
InterPro	IPR004014	http://www.ebi.ac.uk/interpro/entry/IPR004014
InterPro	IPR006544	http://www.ebi.ac.uk/interpro/entry/IPR006544
InterPro	IPR008250	http://www.ebi.ac.uk/interpro/entry/IPR008250
InterPro	IPR018303	http://www.ebi.ac.uk/interpro/entry/IPR018303
InterPro	IPR023214	http://www.ebi.ac.uk/interpro/entry/IPR023214
InterPro	IPR023299	http://www.ebi.ac.uk/interpro/entry/IPR023299
Jabion	344905	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=344905
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:344905	http://www.genome.jp/dbget-bin/www_bget?hsa:344905
KEGG_Orthology	KO:K14951	http://www.genome.jp/dbget-bin/www_bget?KO:K14951
OMA	TTEQHFW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TTEQHFW
OrthoDB	EOG091G01IL	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01IL
PROSITE	PS00154	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00154
PSORT	swissprot:AT135_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AT135_HUMAN
PSORT-B	swissprot:AT135_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AT135_HUMAN
PSORT2	swissprot:AT135_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AT135_HUMAN
Pfam	PF00122	http://pfam.xfam.org/family/PF00122
Pfam	PF00690	http://pfam.xfam.org/family/PF00690
Pfam	PF12409	http://pfam.xfam.org/family/PF12409
PharmGKB	PA134952038	http://www.pharmgkb.org/do/serve?objId=PA134952038&objCls=Gene
Phobius	swissprot:AT135_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AT135_HUMAN
PhylomeDB	Q4VNC0	http://phylomedb.org/?seqid=Q4VNC0
ProteinModelPortal	Q4VNC0	http://www.proteinmodelportal.org/query/uniprot/Q4VNC0
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15925480	http://www.ncbi.nlm.nih.gov/pubmed/15925480
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_940907	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_940907
STRING	9606.ENSP00000341942	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000341942&targetmode=cogs
SUPFAM	SSF56784	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784
SUPFAM	SSF81660	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81660
TIGRFAMs	TIGR01494	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01494
TIGRFAMs	TIGR01657	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01657
UCSC	uc011bsq	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc011bsq&org=rat
UniGene	Hs.658032	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.658032
UniProtKB	AT135_HUMAN	http://www.uniprot.org/uniprot/AT135_HUMAN
UniProtKB-AC	Q4VNC0	http://www.uniprot.org/uniprot/Q4VNC0
charge	swissprot:AT135_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AT135_HUMAN
eggNOG	ENOG410XRCA	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRCA
eggNOG	KOG0208	http://eggnogapi.embl.de/nog_data/html/tree/KOG0208
epestfind	swissprot:AT135_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AT135_HUMAN
garnier	swissprot:AT135_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AT135_HUMAN
helixturnhelix	swissprot:AT135_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AT135_HUMAN
hmoment	swissprot:AT135_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AT135_HUMAN
iep	swissprot:AT135_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AT135_HUMAN
inforesidue	swissprot:AT135_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AT135_HUMAN
neXtProt	NX_Q4VNC0	http://www.nextprot.org/db/entry/NX_Q4VNC0
octanol	swissprot:AT135_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AT135_HUMAN
pepcoil	swissprot:AT135_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AT135_HUMAN
pepdigest	swissprot:AT135_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AT135_HUMAN
pepinfo	swissprot:AT135_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AT135_HUMAN
pepnet	swissprot:AT135_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AT135_HUMAN
pepstats	swissprot:AT135_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AT135_HUMAN
pepwheel	swissprot:AT135_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AT135_HUMAN
pepwindow	swissprot:AT135_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AT135_HUMAN
sigcleave	swissprot:AT135_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AT135_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AT1A3_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P13637-1; Sequence=Displayed; Name=2; IsoId=P13637-2; Sequence=VSP_046956; Name=3; IsoId=P13637-3; Sequence=VSP_046957; 
# AltName	AT1A3_HUMAN	Na(+)/K(+) ATPase alpha(III) subunit
# AltName	AT1A3_HUMAN	Sodium pump subunit alpha-3
# BioGrid	106968	37
# CATALYTIC ACTIVITY	AT1A3_HUMAN	ATP + H(2)O + Na(+)(In) + K(+)(Out) = ADP + phosphate + Na(+)(Out) + K(+)(In). 
# CCDS	CCDS12594	-. [P13637-1]
# CCDS	CCDS58663	-. [P13637-2]
# CCDS	CCDS58664	-. [P13637-3]
# ChiTaRS	ATP1A3	human
# DISEASE	AT1A3_HUMAN	Alternating hemiplegia of childhood 2 (AHC2) [MIM 614820]  A rare syndrome of episodic hemi- or quadriplegia lasting minutes to days. Most cases are accompanied by dystonic posturing, choreoathetoid movements, nystagmus, other ocular motor abnormalities, autonomic disturbances, and progressive cognitive impairment. It is typically distinguished from familial hemiplegic migraine by infantile onset and high prevalence of associated neurological deficits that become increasingly obvious with age. {ECO 0000269|PubMed 22842232, ECO 0000269|PubMed 22850527, ECO 0000269|PubMed 23409136}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	AT1A3_HUMAN	Cerebellar ataxia, areflexia, pes cavus, optic atrophy, and sensorineural hearing loss (CAPOS) [MIM 601338]  An autosomal dominant neurologic disorder characterized by relapsing and partially remitting, early-onset cerebellar ataxia following a febrile illness. Other features include progressive optic atrophy and sensorineural hearing loss, generalized hypotonia, areflexia and pes cavus without evidence of a peripheral neuropathy on neurophysiological studies. {ECO 0000269|PubMed 24468074}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	AT1A3_HUMAN	Dystonia 12 (DYT12) [MIM 128235]  An autosomal dominant dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT12 patients develop dystonia and parkinsonism between 15 and 45 years of age. The disease is characterized by an unusually rapid evolution of signs and symptoms. The sudden onset of symptoms over hours to a few weeks, often associated with physical or emotional stress, suggests a trigger initiating a nervous system insult resulting in permanent neurologic disability. {ECO 0000269|PubMed 15260953, ECO 0000269|PubMed 19351654, ECO 0000269|PubMed 19652145}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000302102	ENSP00000302397; ENSG00000105409. [P13637-1]
# Ensembl	ENST00000543770	ENSP00000437577; ENSG00000105409. [P13637-2]
# Ensembl	ENST00000545399	ENSP00000444688; ENSG00000105409. [P13637-3]
# ExpressionAtlas	P13637	baseline and differential
# FUNCTION	AT1A3_HUMAN	This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. 
# GO_component	AT1A3_HUMAN	GO 0005890 sodium potassium-exchanging ATPase complex; IC UniProtKB.
# GO_component	GO:0005634	nucleus; IEA:Ensembl.
# GO_component	GO:0005783	endoplasmic reticulum; IDA:UniProtKB.
# GO_component	GO:0005794	Golgi apparatus; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0030424	axon; IEA:Ensembl.
# GO_component	GO:0042383	sarcolemma; IEA:Ensembl.
# GO_component	GO:0043209	myelin sheath; IEA:Ensembl.
# GO_component	GO:0044326	dendritic spine neck; IEA:Ensembl.
# GO_component	GO:0044327	dendritic spine head; IEA:Ensembl.
# GO_component	GO:0045202	synapse; ISS:UniProtKB.
# GO_component	GO:1903561	extracellular vesicle; IDA:UniProtKB.
# GO_function	AT1A3_HUMAN	GO 0005391 sodium potassium-exchanging ATPase activity; IMP UniProtKB.
# GO_function	AT1A3_HUMAN	GO 0086037 sodium potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential; IEA Ensembl.
# GO_function	GO:0005524	ATP binding; NAS:UniProtKB.
# GO_function	GO:0043395	heparan sulfate proteoglycan binding; IEA:Ensembl.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_function	GO:0051087	chaperone binding; IPI:BHF-UCL.
# GO_function	GO:1990239	steroid hormone binding; NAS:BHF-UCL.
# GO_process	GO:0006883	cellular sodium ion homeostasis; IDA:BHF-UCL.
# GO_process	GO:0007613	memory; IEA:Ensembl.
# GO_process	GO:0008344	adult locomotory behavior; IEA:Ensembl.
# GO_process	GO:0008542	visual learning; IEA:Ensembl.
# GO_process	GO:0010107	potassium ion import; IDA:BHF-UCL.
# GO_process	GO:0015991	ATP hydrolysis coupled proton transport; IBA:GO_Central.
# GO_process	GO:0030007	cellular potassium ion homeostasis; IDA:BHF-UCL.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0035235	ionotropic glutamate receptor signaling pathway; IEA:Ensembl.
# GO_process	GO:0036376	sodium ion export from cell; IDA:BHF-UCL.
# GO_process	GO:0042493	response to drug; IEA:Ensembl.
# GO_process	GO:0060048	cardiac muscle contraction; IEA:Ensembl.
# GO_process	GO:0071383	cellular response to steroid hormone stimulus; NAS:BHF-UCL.
# GO_process	GO:0086064	cell communication by electrical coupling involved in cardiac conduction; TAS:BHF-UCL.
# GO_process	GO:1903416	response to glycoside; NAS:BHF-UCL.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008289	lipid binding
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.1110.10	-; 2.
# Gene3D	2.70.150.10	-; 2.
# Gene3D	3.40.1110.10	-; 1.
# Genevisible	P13637	HS
# HGNC	HGNC:801	ATP1A3
# IntAct	P13637	6
# InterPro	IPR001757	P_typ_ATPase
# InterPro	IPR004014	ATPase_P-typ_cation-transptr_N
# InterPro	IPR005775	P-type_ATPase_IIC
# InterPro	IPR006068	ATPase_P-typ_cation-transptr_C
# InterPro	IPR008250	ATPase_P-typ_transduc_dom_A
# InterPro	IPR018303	ATPase_P-typ_P_site
# InterPro	IPR023214	HAD-like_dom
# InterPro	IPR023298	ATPase_P-typ_TM_dom
# InterPro	IPR023299	ATPase_P-typ_cyto_domN
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Disease	H00831	[Nervous system disease] Primary dystonia
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko04960	Aldosterone-regulated sodium reabsorption
# KEGG_Pathway	ko04961	Endocrine and other factor-regulated calcium reabsorption
# KEGG_Pathway	ko04964	Proximal tubule bicarbonate reclamation
# KEGG_Pathway	ko04970	Salivary secretion
# KEGG_Pathway	ko04971	Gastric acid secretion
# KEGG_Pathway	ko04972	Pancreatic secretion
# KEGG_Pathway	ko04973	Carbohydrate digestion and absorption
# KEGG_Pathway	ko04974	Protein digestion and absorption
# KEGG_Pathway	ko04976	Bile secretion
# KEGG_Pathway	ko04978	Mineral absorption
# MIM	128235	phenotype
# MIM	182350	gene
# MIM	601338	phenotype
# MIM	614820	phenotype
# Organism	AT1A3_HUMAN	Homo sapiens (Human)
# Orphanet	1171	Cerebellar ataxia - areflexia - pes cavus - optic atrophy - sensorineural hearing loss
# Orphanet	2131	Alternating hemiplegia of childhood
# Orphanet	71517	Rapid-onset dystonia-parkinsonism
# PIR	S00801	S00801
# PROSITE	PS00154	ATPASE_E1_E2
# Pfam	PF00122	E1-E2_ATPase
# Pfam	PF00689	Cation_ATPase_C
# Pfam	PF00690	Cation_ATPase_N
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-5578775	Ion homeostasis
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	AT1A3_HUMAN	Sodium/potassium-transporting ATPase subunit alpha-3
# RefSeq	NP_001243142	NM_001256213.1. [P13637-2]
# RefSeq	NP_001243143	NM_001256214.1. [P13637-3]
# RefSeq	NP_689509	NM_152296.4. [P13637-1]
# SIMILARITY	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. {ECO	0000305}.
# SMART	SM00831	Cation_ATPase_N
# SUBCELLULAR LOCATION	AT1A3_HUMAN	Cell membrane {ECO 0000269|PubMed 7711835}; Multi-pass membrane protein {ECO 0000269|PubMed 7711835}. 
# SUBUNIT	Composed of three subunits	 alpha (catalytic), beta and gamma. 
# SUPFAM	SSF56784	SSF56784; 3
# SUPFAM	SSF81660	SSF81660
# TCDB	3.A.3.1	the p-type atpase (p-atpase) superfamily
# TIGRFAMs	TIGR01106	ATPase-IIC_X-K
# TIGRFAMs	TIGR01494	ATPase_P-type; 2
# UCSC	uc002osg	human. [P13637-1]
# eggNOG	COG0474	LUCA
# eggNOG	KOG0203	Eukaryota
BLAST	swissprot:AT1A3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AT1A3_HUMAN
BioCyc	ZFISH:HS02735-MONOMER	http://biocyc.org/getid?id=ZFISH:HS02735-MONOMER
COXPRESdb	478	http://coxpresdb.jp/data/gene/478.shtml
CleanEx	HS_ATP1A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP1A3
DOI	10.1016/0014-5793(87)80677-4	http://dx.doi.org/10.1016/0014-5793(87)80677-4
DOI	10.1016/0014-5793(87)81467-9	http://dx.doi.org/10.1016/0014-5793(87)81467-9
DOI	10.1016/0014-5793(88)81361-9	http://dx.doi.org/10.1016/0014-5793(88)81361-9
DOI	10.1016/S1474-4422(12)70182-5	http://dx.doi.org/10.1016/S1474-4422(12)70182-5
DOI	10.1016/j.neuron.2004.06.028	http://dx.doi.org/10.1016/j.neuron.2004.06.028
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DOI	10.1038/ng.2358	http://dx.doi.org/10.1038/ng.2358
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/hmg/ddp170	http://dx.doi.org/10.1093/hmg/ddp170
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1750-1172-9-15	http://dx.doi.org/10.1186/1750-1172-9-15
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1212/WNL.0b013e3181b04acd	http://dx.doi.org/10.1212/WNL.0b013e3181b04acd
DOI	10.1371/journal.pone.0056120	http://dx.doi.org/10.1371/journal.pone.0056120
DOI	10.3109/09687689409160435	http://dx.doi.org/10.3109/09687689409160435
EC_number	EC:3.6.3.9	http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.9
EMBL	AC010616	http://www.ebi.ac.uk/ena/data/view/AC010616
EMBL	AK295078	http://www.ebi.ac.uk/ena/data/view/AK295078
EMBL	AK296557	http://www.ebi.ac.uk/ena/data/view/AK296557
EMBL	BC009282	http://www.ebi.ac.uk/ena/data/view/BC009282
EMBL	BC009394	http://www.ebi.ac.uk/ena/data/view/BC009394
EMBL	BC015566	http://www.ebi.ac.uk/ena/data/view/BC015566
EMBL	M27570	http://www.ebi.ac.uk/ena/data/view/M27570
EMBL	M27573	http://www.ebi.ac.uk/ena/data/view/M27573
EMBL	M27577	http://www.ebi.ac.uk/ena/data/view/M27577
EMBL	M28284	http://www.ebi.ac.uk/ena/data/view/M28284
EMBL	M28285	http://www.ebi.ac.uk/ena/data/view/M28285
EMBL	M28286	http://www.ebi.ac.uk/ena/data/view/M28286
EMBL	M28287	http://www.ebi.ac.uk/ena/data/view/M28287
EMBL	M28289	http://www.ebi.ac.uk/ena/data/view/M28289
EMBL	M28290	http://www.ebi.ac.uk/ena/data/view/M28290
EMBL	M28291	http://www.ebi.ac.uk/ena/data/view/M28291
EMBL	M28292	http://www.ebi.ac.uk/ena/data/view/M28292
EMBL	M28293	http://www.ebi.ac.uk/ena/data/view/M28293
EMBL	M35821	http://www.ebi.ac.uk/ena/data/view/M35821
EMBL	M35822	http://www.ebi.ac.uk/ena/data/view/M35822
EMBL	M37436	http://www.ebi.ac.uk/ena/data/view/M37436
EMBL	M37437	http://www.ebi.ac.uk/ena/data/view/M37437
EMBL	M37438	http://www.ebi.ac.uk/ena/data/view/M37438
EMBL	M37439	http://www.ebi.ac.uk/ena/data/view/M37439
EMBL	M37440	http://www.ebi.ac.uk/ena/data/view/M37440
EMBL	M37441	http://www.ebi.ac.uk/ena/data/view/M37441
EMBL	M37442	http://www.ebi.ac.uk/ena/data/view/M37442
EMBL	M37443	http://www.ebi.ac.uk/ena/data/view/M37443
EMBL	M37444	http://www.ebi.ac.uk/ena/data/view/M37444
EMBL	M37445	http://www.ebi.ac.uk/ena/data/view/M37445
EMBL	M37447	http://www.ebi.ac.uk/ena/data/view/M37447
EMBL	M37448	http://www.ebi.ac.uk/ena/data/view/M37448
EMBL	M37449	http://www.ebi.ac.uk/ena/data/view/M37449
EMBL	M37450	http://www.ebi.ac.uk/ena/data/view/M37450
EMBL	M37451	http://www.ebi.ac.uk/ena/data/view/M37451
EMBL	M37452	http://www.ebi.ac.uk/ena/data/view/M37452
EMBL	M37453	http://www.ebi.ac.uk/ena/data/view/M37453
EMBL	M37454	http://www.ebi.ac.uk/ena/data/view/M37454
EMBL	M37455	http://www.ebi.ac.uk/ena/data/view/M37455
EMBL	M37456	http://www.ebi.ac.uk/ena/data/view/M37456
EMBL	M37457	http://www.ebi.ac.uk/ena/data/view/M37457
EMBL	M37462	http://www.ebi.ac.uk/ena/data/view/M37462
EMBL	X12910	http://www.ebi.ac.uk/ena/data/view/X12910
EMBL	X12911	http://www.ebi.ac.uk/ena/data/view/X12911
EMBL	X12912	http://www.ebi.ac.uk/ena/data/view/X12912
EMBL	X12913	http://www.ebi.ac.uk/ena/data/view/X12913
EMBL	X12914	http://www.ebi.ac.uk/ena/data/view/X12914
EMBL	X12915	http://www.ebi.ac.uk/ena/data/view/X12915
EMBL	X12916	http://www.ebi.ac.uk/ena/data/view/X12916
EMBL	X12917	http://www.ebi.ac.uk/ena/data/view/X12917
EMBL	X12919	http://www.ebi.ac.uk/ena/data/view/X12919
EMBL	X12920	http://www.ebi.ac.uk/ena/data/view/X12920
EMBL	X12921	http://www.ebi.ac.uk/ena/data/view/X12921
EMBL	X12922	http://www.ebi.ac.uk/ena/data/view/X12922
EMBL	X12923	http://www.ebi.ac.uk/ena/data/view/X12923
ENZYME	3.6.3.9	http://enzyme.expasy.org/EC/3.6.3.9
Ensembl	ENST00000302102	http://www.ensembl.org/id/ENST00000302102
Ensembl	ENST00000543770	http://www.ensembl.org/id/ENST00000543770
Ensembl	ENST00000545399	http://www.ensembl.org/id/ENST00000545399
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005890
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030424	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030424
GO_component	GO:0042383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042383
GO_component	GO:0043209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043209
GO_component	GO:0044326	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044326
GO_component	GO:0044327	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044327
GO_component	GO:0045202	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045202
GO_component	GO:1903561	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903561
GO_function	GO:0005391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005391
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0043395	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043395
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_function	GO:0051087	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051087
GO_function	GO:0086037	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086037
GO_function	GO:1990239	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990239
GO_process	GO:0006883	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006883
GO_process	GO:0007613	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007613
GO_process	GO:0008344	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008344
GO_process	GO:0008542	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008542
GO_process	GO:0010107	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010107
GO_process	GO:0015991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015991
GO_process	GO:0030007	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030007
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0035235	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035235
GO_process	GO:0036376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036376
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0060048	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060048
GO_process	GO:0071383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071383
GO_process	GO:0086064	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086064
GO_process	GO:1903416	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903416
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.1110.10	http://www.cathdb.info/version/latest/superfamily/1.20.1110.10
Gene3D	2.70.150.10	http://www.cathdb.info/version/latest/superfamily/2.70.150.10
Gene3D	3.40.1110.10	http://www.cathdb.info/version/latest/superfamily/3.40.1110.10
GeneCards	ATP1A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP1A3
GeneID	478	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=478
GeneTree	ENSGT00850000132256	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00850000132256
HGNC	HGNC:801	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:801
HOGENOM	HOG000265622	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265622&db=HOGENOM6
HOVERGEN	HBG004298	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004298&db=HOVERGEN
HPA	CAB033630	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB033630
HPA	HPA045367	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA045367
HPA	HPA056446	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA056446
InParanoid	P13637	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P13637
IntAct	P13637	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P13637*
IntEnz	3.6.3.9	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.9
InterPro	IPR001757	http://www.ebi.ac.uk/interpro/entry/IPR001757
InterPro	IPR004014	http://www.ebi.ac.uk/interpro/entry/IPR004014
InterPro	IPR005775	http://www.ebi.ac.uk/interpro/entry/IPR005775
InterPro	IPR006068	http://www.ebi.ac.uk/interpro/entry/IPR006068
InterPro	IPR008250	http://www.ebi.ac.uk/interpro/entry/IPR008250
InterPro	IPR018303	http://www.ebi.ac.uk/interpro/entry/IPR018303
InterPro	IPR023214	http://www.ebi.ac.uk/interpro/entry/IPR023214
InterPro	IPR023298	http://www.ebi.ac.uk/interpro/entry/IPR023298
InterPro	IPR023299	http://www.ebi.ac.uk/interpro/entry/IPR023299
Jabion	478	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=478
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Disease	H00831	http://www.genome.jp/dbget-bin/www_bget?H00831
KEGG_Gene	hsa:478	http://www.genome.jp/dbget-bin/www_bget?hsa:478
KEGG_Orthology	KO:K01539	http://www.genome.jp/dbget-bin/www_bget?KO:K01539
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko04960	http://www.genome.jp/kegg-bin/show_pathway?ko04960
KEGG_Pathway	ko04961	http://www.genome.jp/kegg-bin/show_pathway?ko04961
KEGG_Pathway	ko04964	http://www.genome.jp/kegg-bin/show_pathway?ko04964
KEGG_Pathway	ko04970	http://www.genome.jp/kegg-bin/show_pathway?ko04970
KEGG_Pathway	ko04971	http://www.genome.jp/kegg-bin/show_pathway?ko04971
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
KEGG_Pathway	ko04973	http://www.genome.jp/kegg-bin/show_pathway?ko04973
KEGG_Pathway	ko04974	http://www.genome.jp/kegg-bin/show_pathway?ko04974
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
KEGG_Pathway	ko04978	http://www.genome.jp/kegg-bin/show_pathway?ko04978
MIM	128235	http://www.ncbi.nlm.nih.gov/omim/128235
MIM	182350	http://www.ncbi.nlm.nih.gov/omim/182350
MIM	601338	http://www.ncbi.nlm.nih.gov/omim/601338
MIM	614820	http://www.ncbi.nlm.nih.gov/omim/614820
MINT	MINT-2857038	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-2857038
Orphanet	1171	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1171
Orphanet	2131	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=2131
Orphanet	71517	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=71517
OrthoDB	EOG091G01BB	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01BB
PROSITE	PS00154	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00154
PSORT	swissprot:AT1A3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AT1A3_HUMAN
PSORT-B	swissprot:AT1A3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AT1A3_HUMAN
PSORT2	swissprot:AT1A3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AT1A3_HUMAN
Pfam	PF00122	http://pfam.xfam.org/family/PF00122
Pfam	PF00689	http://pfam.xfam.org/family/PF00689
Pfam	PF00690	http://pfam.xfam.org/family/PF00690
PharmGKB	PA64	http://www.pharmgkb.org/do/serve?objId=PA64&objCls=Gene
Phobius	swissprot:AT1A3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AT1A3_HUMAN
PhylomeDB	P13637	http://phylomedb.org/?seqid=P13637
ProteinModelPortal	P13637	http://www.proteinmodelportal.org/query/uniprot/P13637
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	15260953	http://www.ncbi.nlm.nih.gov/pubmed/15260953
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19351654	http://www.ncbi.nlm.nih.gov/pubmed/19351654
PubMed	19652145	http://www.ncbi.nlm.nih.gov/pubmed/19652145
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22842232	http://www.ncbi.nlm.nih.gov/pubmed/22842232
PubMed	22850527	http://www.ncbi.nlm.nih.gov/pubmed/22850527
PubMed	23409136	http://www.ncbi.nlm.nih.gov/pubmed/23409136
PubMed	24468074	http://www.ncbi.nlm.nih.gov/pubmed/24468074
PubMed	2834163	http://www.ncbi.nlm.nih.gov/pubmed/2834163
PubMed	2838329	http://www.ncbi.nlm.nih.gov/pubmed/2838329
PubMed	3030810	http://www.ncbi.nlm.nih.gov/pubmed/3030810
PubMed	3036582	http://www.ncbi.nlm.nih.gov/pubmed/3036582
PubMed	7711835	http://www.ncbi.nlm.nih.gov/pubmed/7711835
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_001243142	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243142
RefSeq	NP_001243143	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243143
RefSeq	NP_689509	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_689509
SMART	SM00831	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00831
SMR	P13637	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P13637
STRING	9606.ENSP00000302397	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000302397&targetmode=cogs
SUPFAM	SSF56784	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784
SUPFAM	SSF81660	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81660
TCDB	3.A.3.1	http://www.tcdb.org/search/result.php?tc=3.A.3.1
TIGRFAMs	TIGR01106	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01106
TIGRFAMs	TIGR01494	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01494
UCSC	uc002osg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002osg&org=rat
UniGene	Hs.515427	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.515427
UniProtKB	AT1A3_HUMAN	http://www.uniprot.org/uniprot/AT1A3_HUMAN
UniProtKB-AC	P13637	http://www.uniprot.org/uniprot/P13637
charge	swissprot:AT1A3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AT1A3_HUMAN
eggNOG	COG0474	http://eggnogapi.embl.de/nog_data/html/tree/COG0474
eggNOG	KOG0203	http://eggnogapi.embl.de/nog_data/html/tree/KOG0203
epestfind	swissprot:AT1A3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AT1A3_HUMAN
garnier	swissprot:AT1A3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AT1A3_HUMAN
helixturnhelix	swissprot:AT1A3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AT1A3_HUMAN
hmoment	swissprot:AT1A3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AT1A3_HUMAN
iep	swissprot:AT1A3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AT1A3_HUMAN
inforesidue	swissprot:AT1A3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AT1A3_HUMAN
neXtProt	NX_P13637	http://www.nextprot.org/db/entry/NX_P13637
octanol	swissprot:AT1A3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AT1A3_HUMAN
pepcoil	swissprot:AT1A3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AT1A3_HUMAN
pepdigest	swissprot:AT1A3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AT1A3_HUMAN
pepinfo	swissprot:AT1A3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AT1A3_HUMAN
pepnet	swissprot:AT1A3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AT1A3_HUMAN
pepstats	swissprot:AT1A3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AT1A3_HUMAN
pepwheel	swissprot:AT1A3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AT1A3_HUMAN
pepwindow	swissprot:AT1A3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AT1A3_HUMAN
sigcleave	swissprot:AT1A3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AT1A3_HUMAN
## Database	ID	URL or Descriptions
# AltName	GBRD_HUMAN	GABA(A) receptor subunit delta
# BioGrid	108837	15
# DISEASE	GBRD_HUMAN	Epilepsy, idiopathic generalized 10 (EIG10) [MIM 613060]  A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# DISEASE	GBRD_HUMAN	Generalized epilepsy with febrile seizures plus 5 (GEFS+5) [MIM 613060]  A rare autosomal dominant, familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. This disease combines febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity. {ECO 0000269|PubMed 15115768}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# DISEASE	GBRD_HUMAN	Juvenile myoclonic epilepsy 7 (EJM7) [MIM 613060]  A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# DrugBank	DB00186	Lorazepam
# DrugBank	DB00189	Ethchlorvynol
# DrugBank	DB00228	Enflurane
# DrugBank	DB00231	Temazepam
# DrugBank	DB00237	Butabarbital
# DrugBank	DB00241	Butalbital
# DrugBank	DB00273	Topiramate
# DrugBank	DB00292	Etomidate
# DrugBank	DB00306	Talbutal
# DrugBank	DB00312	Pentobarbital
# DrugBank	DB00334	Olanzapine
# DrugBank	DB00349	Clobazam
# DrugBank	DB00371	Meprobamate
# DrugBank	DB00402	Eszopiclone
# DrugBank	DB00404	Alprazolam
# DrugBank	DB00475	Chlordiazepoxide
# DrugBank	DB00543	Amoxapine
# DrugBank	DB00546	Adinazolam
# DrugBank	DB00628	Clorazepate
# DrugBank	DB00659	Acamprosate
# DrugBank	DB00683	Midazolam
# DrugBank	DB00690	Flurazepam
# DrugBank	DB00753	Isoflurane
# DrugBank	DB00794	Primidone
# DrugBank	DB00801	Halazepam
# DrugBank	DB00818	Propofol
# DrugBank	DB00829	Diazepam
# DrugBank	DB00842	Oxazepam
# DrugBank	DB00897	Triazolam
# DrugBank	DB00898	Ethanol
# DrugBank	DB01028	Methoxyflurane
# DrugBank	DB01049	Ergoloid mesylate
# DrugBank	DB01068	Clonazepam
# DrugBank	DB01107	Methyprylon
# DrugBank	DB01159	Halothane
# DrugBank	DB01189	Desflurane
# DrugBank	DB01205	Flumazenil
# DrugBank	DB01215	Estazolam
# DrugBank	DB01236	Sevoflurane
# DrugBank	DB01437	Glutethimide
# DrugBank	DB01558	Bromazepam
# DrugBank	DB01559	Clotiazepam
# DrugBank	DB01567	Fludiazepam
# DrugBank	DB01587	Ketazolam
# DrugBank	DB01588	Prazepam
# DrugBank	DB01589	Quazepam
# DrugBank	DB01594	Cinolazepam
# DrugBank	DB01595	Nitrazepam
# Ensembl	ENST00000378585	ENSP00000367848; ENSG00000187730
# FUNCTION	GBRD_HUMAN	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. 
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:1902711	GABA-A receptor complex; IBA:GO_Central.
# GO_function	GO:0004890	GABA-A receptor activity; TAS:ProtInc.
# GO_function	GO:0005230	extracellular ligand-gated ion channel activity; IEA:InterPro.
# GO_function	GO:0005254	chloride channel activity; IEA:UniProtKB-KW.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0007268	chemical synaptic transmission; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# Gene3D	2.70.170.10	-; 1.
# Genevisible	O14764	HS
# HGNC	HGNC:4084	GABRD
# INTERACTION	GBRD_HUMAN	Q7Z3S9 NOTCH2NL; NbExp=3; IntAct=EBI-744352, EBI-945833; Q9UMX0 UBQLN1; NbExp=4; IntAct=EBI-744352, EBI-741480; Q9UMX0-2 UBQLN1; NbExp=3; IntAct=EBI-744352, EBI-10173939; 
# IntAct	O14764	4
# InterPro	IPR006028	GABAA/Glycine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR008098	GABAAd_rcpt
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00783	[Nervous system disease; Epilepsy] Dravet syndrome/ Severe myoclonic epilepsy in infancy (SMEI)
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04727	GABAergic synapse
# KEGG_Pathway	ko05032	Morphine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# MIM	137163	gene
# MIM	613060	phenotype
# Organism	GBRD_HUMAN	Homo sapiens (Human)
# Orphanet	1606	1p36 deletion syndrome
# Orphanet	307	Juvenile myoclonic epilepsy
# Orphanet	36387	Generalized epilepsy with febrile seizures-plus
# PANTHER	PTHR18945	PTHR18945; 2
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00253	GABAARECEPTR
# PRINTS	PR01722	GABAARDELTA
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 1
# RecName	GBRD_HUMAN	Gamma-aminobutyric acid receptor subunit delta
# RefSeq	NP_000806	NM_000815.4
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRD sub-subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	GBRD_HUMAN	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Generally pentameric. There are five types of GABA(A) receptor chains	 alpha, beta, gamma, delta, and rho. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TIGRFAMs	TIGR00860	LIC
# UCSC	uc001aip	human
# eggNOG	ENOG410XPWH	LUCA
# eggNOG	KOG3643	Eukaryota
BLAST	swissprot:GBRD_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GBRD_HUMAN
BioCyc	ZFISH:G66-33669-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33669-MONOMER
COXPRESdb	2563	http://coxpresdb.jp/data/gene/2563.shtml
CleanEx	HS_GABRD	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GABRD
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1093/hmg/ddh146	http://dx.doi.org/10.1093/hmg/ddh146
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00186	http://www.drugbank.ca/drugs/DB00186
DrugBank	DB00189	http://www.drugbank.ca/drugs/DB00189
DrugBank	DB00228	http://www.drugbank.ca/drugs/DB00228
DrugBank	DB00231	http://www.drugbank.ca/drugs/DB00231
DrugBank	DB00237	http://www.drugbank.ca/drugs/DB00237
DrugBank	DB00241	http://www.drugbank.ca/drugs/DB00241
DrugBank	DB00273	http://www.drugbank.ca/drugs/DB00273
DrugBank	DB00292	http://www.drugbank.ca/drugs/DB00292
DrugBank	DB00306	http://www.drugbank.ca/drugs/DB00306
DrugBank	DB00312	http://www.drugbank.ca/drugs/DB00312
DrugBank	DB00334	http://www.drugbank.ca/drugs/DB00334
DrugBank	DB00349	http://www.drugbank.ca/drugs/DB00349
DrugBank	DB00371	http://www.drugbank.ca/drugs/DB00371
DrugBank	DB00402	http://www.drugbank.ca/drugs/DB00402
DrugBank	DB00404	http://www.drugbank.ca/drugs/DB00404
DrugBank	DB00475	http://www.drugbank.ca/drugs/DB00475
DrugBank	DB00543	http://www.drugbank.ca/drugs/DB00543
DrugBank	DB00546	http://www.drugbank.ca/drugs/DB00546
DrugBank	DB00628	http://www.drugbank.ca/drugs/DB00628
DrugBank	DB00659	http://www.drugbank.ca/drugs/DB00659
DrugBank	DB00683	http://www.drugbank.ca/drugs/DB00683
DrugBank	DB00690	http://www.drugbank.ca/drugs/DB00690
DrugBank	DB00753	http://www.drugbank.ca/drugs/DB00753
DrugBank	DB00794	http://www.drugbank.ca/drugs/DB00794
DrugBank	DB00801	http://www.drugbank.ca/drugs/DB00801
DrugBank	DB00818	http://www.drugbank.ca/drugs/DB00818
DrugBank	DB00829	http://www.drugbank.ca/drugs/DB00829
DrugBank	DB00842	http://www.drugbank.ca/drugs/DB00842
DrugBank	DB00897	http://www.drugbank.ca/drugs/DB00897
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01028	http://www.drugbank.ca/drugs/DB01028
DrugBank	DB01049	http://www.drugbank.ca/drugs/DB01049
DrugBank	DB01068	http://www.drugbank.ca/drugs/DB01068
DrugBank	DB01107	http://www.drugbank.ca/drugs/DB01107
DrugBank	DB01159	http://www.drugbank.ca/drugs/DB01159
DrugBank	DB01189	http://www.drugbank.ca/drugs/DB01189
DrugBank	DB01205	http://www.drugbank.ca/drugs/DB01205
DrugBank	DB01215	http://www.drugbank.ca/drugs/DB01215
DrugBank	DB01236	http://www.drugbank.ca/drugs/DB01236
DrugBank	DB01437	http://www.drugbank.ca/drugs/DB01437
DrugBank	DB01558	http://www.drugbank.ca/drugs/DB01558
DrugBank	DB01559	http://www.drugbank.ca/drugs/DB01559
DrugBank	DB01567	http://www.drugbank.ca/drugs/DB01567
DrugBank	DB01587	http://www.drugbank.ca/drugs/DB01587
DrugBank	DB01588	http://www.drugbank.ca/drugs/DB01588
DrugBank	DB01589	http://www.drugbank.ca/drugs/DB01589
DrugBank	DB01594	http://www.drugbank.ca/drugs/DB01594
DrugBank	DB01595	http://www.drugbank.ca/drugs/DB01595
EMBL	AF016917	http://www.ebi.ac.uk/ena/data/view/AF016917
EMBL	AL391845	http://www.ebi.ac.uk/ena/data/view/AL391845
EMBL	BC033801	http://www.ebi.ac.uk/ena/data/view/BC033801
Ensembl	ENST00000378585	http://www.ensembl.org/id/ENST00000378585
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_component	GO:1902711	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902711
GO_function	GO:0004890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004890
GO_function	GO:0005230	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005230
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	GABRD	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GABRD
GeneID	2563	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2563
GeneTree	ENSGT00760000118821	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118821
HGNC	HGNC:4084	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4084
HOGENOM	HOG000231335	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231335&db=HOGENOM6
HOVERGEN	HBG051707	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051707&db=HOVERGEN
HPA	HPA044371	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA044371
InParanoid	O14764	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O14764
IntAct	O14764	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O14764*
InterPro	IPR006028	http://www.ebi.ac.uk/interpro/entry/IPR006028
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR008098	http://www.ebi.ac.uk/interpro/entry/IPR008098
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
Jabion	2563	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2563
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00783	http://www.genome.jp/dbget-bin/www_bget?H00783
KEGG_Gene	hsa:2563	http://www.genome.jp/dbget-bin/www_bget?hsa:2563
KEGG_Orthology	KO:K05184	http://www.genome.jp/dbget-bin/www_bget?KO:K05184
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
KEGG_Pathway	ko05032	http://www.genome.jp/kegg-bin/show_pathway?ko05032
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
MIM	137163	http://www.ncbi.nlm.nih.gov/omim/137163
MIM	613060	http://www.ncbi.nlm.nih.gov/omim/613060
MINT	MINT-1461496	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1461496
OMA	IVYHWSE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IVYHWSE
Orphanet	1606	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1606
Orphanet	307	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=307
Orphanet	36387	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=36387
OrthoDB	EOG091G0805	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0805
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00253	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00253
PRINTS	PR01722	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01722
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:GBRD_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GBRD_HUMAN
PSORT-B	swissprot:GBRD_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GBRD_HUMAN
PSORT2	swissprot:GBRD_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GBRD_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA28498	http://www.pharmgkb.org/do/serve?objId=PA28498&objCls=Gene
Phobius	swissprot:GBRD_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GBRD_HUMAN
PhylomeDB	O14764	http://phylomedb.org/?seqid=O14764
ProteinModelPortal	O14764	http://www.proteinmodelportal.org/query/uniprot/O14764
PubMed	15115768	http://www.ncbi.nlm.nih.gov/pubmed/15115768
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
RefSeq	NP_000806	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000806
SMR	O14764	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O14764
STRING	9606.ENSP00000367848	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000367848&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc001aip	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001aip&org=rat
UniGene	Hs.113882	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.113882
UniProtKB	GBRD_HUMAN	http://www.uniprot.org/uniprot/GBRD_HUMAN
UniProtKB-AC	O14764	http://www.uniprot.org/uniprot/O14764
charge	swissprot:GBRD_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GBRD_HUMAN
eggNOG	ENOG410XPWH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPWH
eggNOG	KOG3643	http://eggnogapi.embl.de/nog_data/html/tree/KOG3643
epestfind	swissprot:GBRD_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GBRD_HUMAN
garnier	swissprot:GBRD_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GBRD_HUMAN
helixturnhelix	swissprot:GBRD_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GBRD_HUMAN
hmoment	swissprot:GBRD_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GBRD_HUMAN
iep	swissprot:GBRD_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GBRD_HUMAN
inforesidue	swissprot:GBRD_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GBRD_HUMAN
neXtProt	NX_O14764	http://www.nextprot.org/db/entry/NX_O14764
octanol	swissprot:GBRD_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GBRD_HUMAN
pepcoil	swissprot:GBRD_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GBRD_HUMAN
pepdigest	swissprot:GBRD_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GBRD_HUMAN
pepinfo	swissprot:GBRD_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GBRD_HUMAN
pepnet	swissprot:GBRD_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GBRD_HUMAN
pepstats	swissprot:GBRD_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GBRD_HUMAN
pepwheel	swissprot:GBRD_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GBRD_HUMAN
pepwindow	swissprot:GBRD_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GBRD_HUMAN
sigcleave	swissprot:GBRD_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GBRD_HUMAN
## Database	ID	URL or Descriptions
# AltName	ORAI2_HUMAN	CAP-binding protein complex-interacting protein 2
# AltName	ORAI2_HUMAN	Transmembrane protein 142B
# BioGrid	123192	5
# ChiTaRS	ORAI2	human
# Ensembl	ENST00000356387	ENSP00000348752; ENSG00000160991
# Ensembl	ENST00000403646	ENSP00000385489; ENSG00000160991
# Ensembl	ENST00000473939	ENSP00000417928; ENSG00000160991
# Ensembl	ENST00000478730	ENSP00000418140; ENSG00000160991
# Ensembl	ENST00000611770	ENSP00000478113; ENSG00000160991
# ExpressionAtlas	Q96SN7	baseline and differential
# FUNCTION	ORAI2_HUMAN	Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)- selective current by synergy with the Ca(2+) sensor, STIM1. {ECO 0000269|PubMed 16807233, ECO 0000269|PubMed 17452328}. 
# GO_component	GO:0016020	membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0030426	growth cone; IEA:Ensembl.
# GO_function	GO:0015279	store-operated calcium channel activity; IBA:GO_Central.
# GO_process	GO:0002115	store-operated calcium entry; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q96SN7	HS
# HGNC	HGNC:21667	ORAI2
# IntAct	Q96SN7	7
# InterPro	IPR012446	CRAC_channel
# InterPro	IPR030034	Orai-2
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Pathway	ko04020	Calcium signaling pathway
# MIM	610929	gene
# Organism	ORAI2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR31501	PTHR31501
# PANTHER	PTHR31501:SF5	PTHR31501:SF5
# Pfam	PF07856	Orai-1
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-139853	Elevation of cytosolic Ca2+ levels
# Reactome	R-HSA-5578775	Ion homeostasis
# Reactome	R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
# RecName	ORAI2_HUMAN	Protein orai-2
# RefSeq	NP_001119812	NM_001126340.2
# RefSeq	NP_001258747	NM_001271818.1
# RefSeq	NP_116220	NM_032831.3
# SEQUENCE CAUTION	Sequence=AAG23755.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAP22352.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305}; Sequence=CAG33568.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
# SIMILARITY	Belongs to the Orai family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	ORAI2_HUMAN	Membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUBUNIT	Interacts with CRACR2A/EFCAB4B. {ECO:0000269|PubMed	20418871}. 
# UCSC	uc003uzj	human
# eggNOG	ENOG4110DSB	LUCA
# eggNOG	KOG4298	Eukaryota
BLAST	swissprot:ORAI2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ORAI2_HUMAN
COXPRESdb	80228	http://coxpresdb.jp/data/gene/80228.shtml
CleanEx	HS_ORAI2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ORAI2
DIP	DIP-48944N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48944N
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1038/nature04702	http://dx.doi.org/10.1038/nature04702
DOI	10.1038/ncb2045	http://dx.doi.org/10.1038/ncb2045
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0404089101	http://dx.doi.org/10.1073/pnas.0404089101
DOI	10.1074/jbc.M604589200	http://dx.doi.org/10.1074/jbc.M604589200
DOI	10.1074/jbc.M611374200	http://dx.doi.org/10.1074/jbc.M611374200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC093668	http://www.ebi.ac.uk/ena/data/view/AC093668
EMBL	AC093668	http://www.ebi.ac.uk/ena/data/view/AC093668
EMBL	AF258552	http://www.ebi.ac.uk/ena/data/view/AF258552
EMBL	AK027639	http://www.ebi.ac.uk/ena/data/view/AK027639
EMBL	BC069270	http://www.ebi.ac.uk/ena/data/view/BC069270
EMBL	CR457287	http://www.ebi.ac.uk/ena/data/view/CR457287
Ensembl	ENST00000356387	http://www.ensembl.org/id/ENST00000356387
Ensembl	ENST00000403646	http://www.ensembl.org/id/ENST00000403646
Ensembl	ENST00000473939	http://www.ensembl.org/id/ENST00000473939
Ensembl	ENST00000478730	http://www.ensembl.org/id/ENST00000478730
Ensembl	ENST00000611770	http://www.ensembl.org/id/ENST00000611770
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030426	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030426
GO_function	GO:0015279	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015279
GO_process	GO:0002115	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002115
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	ORAI2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ORAI2
GeneID	80228	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80228
GeneTree	ENSGT00390000015354	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000015354
HGNC	HGNC:21667	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:21667
HOGENOM	HOG000246925	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000246925&db=HOGENOM6
HOVERGEN	HBG081343	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG081343&db=HOVERGEN
HPA	HPA055137	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA055137
HPA	HPA065937	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA065937
InParanoid	Q96SN7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96SN7
IntAct	Q96SN7	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96SN7*
InterPro	IPR012446	http://www.ebi.ac.uk/interpro/entry/IPR012446
InterPro	IPR030034	http://www.ebi.ac.uk/interpro/entry/IPR030034
Jabion	80228	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=80228
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Gene	hsa:80228	http://www.genome.jp/dbget-bin/www_bget?hsa:80228
KEGG_Orthology	KO:K16057	http://www.genome.jp/dbget-bin/www_bget?KO:K16057
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
MIM	610929	http://www.ncbi.nlm.nih.gov/omim/610929
MINT	MINT-1373233	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1373233
OMA	PACSEPG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PACSEPG
OrthoDB	EOG091G0E4P	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0E4P
PANTHER	PTHR31501	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31501
PANTHER	PTHR31501:SF5	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31501:SF5
PSORT	swissprot:ORAI2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ORAI2_HUMAN
PSORT-B	swissprot:ORAI2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ORAI2_HUMAN
PSORT2	swissprot:ORAI2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ORAI2_HUMAN
Pfam	PF07856	http://pfam.xfam.org/family/PF07856
PharmGKB	PA162398454	http://www.pharmgkb.org/do/serve?objId=PA162398454&objCls=Gene
Phobius	swissprot:ORAI2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ORAI2_HUMAN
PhylomeDB	Q96SN7	http://phylomedb.org/?seqid=Q96SN7
ProteinModelPortal	Q96SN7	http://www.proteinmodelportal.org/query/uniprot/Q96SN7
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15498874	http://www.ncbi.nlm.nih.gov/pubmed/15498874
PubMed	16582901	http://www.ncbi.nlm.nih.gov/pubmed/16582901
PubMed	16807233	http://www.ncbi.nlm.nih.gov/pubmed/16807233
PubMed	17452328	http://www.ncbi.nlm.nih.gov/pubmed/17452328
PubMed	20418871	http://www.ncbi.nlm.nih.gov/pubmed/20418871
Reactome	R-HSA-139853	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-139853
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
Reactome	R-HSA-983695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983695
RefSeq	NP_001119812	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001119812
RefSeq	NP_001258747	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001258747
RefSeq	NP_116220	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_116220
STRING	9606.ENSP00000348752	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000348752&targetmode=cogs
UCSC	uc003uzj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003uzj&org=rat
UniGene	Hs.363308	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.363308
UniGene	Hs.736659	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.736659
UniProtKB	ORAI2_HUMAN	http://www.uniprot.org/uniprot/ORAI2_HUMAN
UniProtKB-AC	Q96SN7	http://www.uniprot.org/uniprot/Q96SN7
charge	swissprot:ORAI2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ORAI2_HUMAN
eggNOG	ENOG4110DSB	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110DSB
eggNOG	KOG4298	http://eggnogapi.embl.de/nog_data/html/tree/KOG4298
epestfind	swissprot:ORAI2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ORAI2_HUMAN
garnier	swissprot:ORAI2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ORAI2_HUMAN
helixturnhelix	swissprot:ORAI2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ORAI2_HUMAN
hmoment	swissprot:ORAI2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ORAI2_HUMAN
iep	swissprot:ORAI2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ORAI2_HUMAN
inforesidue	swissprot:ORAI2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ORAI2_HUMAN
neXtProt	NX_Q96SN7	http://www.nextprot.org/db/entry/NX_Q96SN7
octanol	swissprot:ORAI2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ORAI2_HUMAN
pepcoil	swissprot:ORAI2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ORAI2_HUMAN
pepdigest	swissprot:ORAI2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ORAI2_HUMAN
pepinfo	swissprot:ORAI2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ORAI2_HUMAN
pepnet	swissprot:ORAI2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ORAI2_HUMAN
pepstats	swissprot:ORAI2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ORAI2_HUMAN
pepwheel	swissprot:ORAI2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ORAI2_HUMAN
pepwindow	swissprot:ORAI2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ORAI2_HUMAN
sigcleave	swissprot:ORAI2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ORAI2_HUMAN
## Database	ID	URL or Descriptions
# AltName	YLAT2_HUMAN	Cationic amino acid transporter, y+ system
# AltName	YLAT2_HUMAN	Solute carrier family 7 member 6
# AltName	YLAT2_HUMAN	y(+)L-type amino acid transporter 2
# BIOPHYSICOCHEMICAL PROPERTIES	YLAT2_HUMAN	Kinetic parameters  KM=295 uM for glutamine (in the presence of NaCl) {ECO 0000269|PubMed 10903140}; KM=236 uM for leucine (in the presence of NaCl) {ECO 0000269|PubMed 10903140}; KM=120 uM for arginine (in the presence of NaCl) {ECO 0000269|PubMed 10903140}; KM=138 uM for arginine (in the absence of NaCl) {ECO 0000269|PubMed 10903140}; 
# ChiTaRS	SLC7A6	human
# ENZYME REGULATION	YLAT2_HUMAN	Arginine transport is strongly inhibited by lysine, glutamate, leucine, glutamine, methionine and histidine, in the presence of Na(+). Also inhibited by protein kinase C (PKC) and treatment with phorbol-12-myristate-13-acetate (PMA). Mutual inhibition is observed when leucine or glutamine is used as substrate. Inhibition of arginine and leucine uptake also occurs when SLC3A2/4F2hc is either truncated at its C-terminus or mutated at critical residues within the terminal 15 amino acids. 
# Ensembl	ENST00000219343	ENSP00000219343; ENSG00000103064
# Ensembl	ENST00000566454	ENSP00000455064; ENSG00000103064
# ExpressionAtlas	Q92536	baseline and differential
# FUNCTION	YLAT2_HUMAN	Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells. {ECO 0000269|PubMed 10903140, ECO 0000269|PubMed 11311135, ECO 0000269|PubMed 14603368, ECO 0000269|PubMed 15280038, ECO 0000269|PubMed 16785209, ECO 0000269|PubMed 17197568, ECO 0000269|PubMed 17329401, ECO 0000269|PubMed 9829974}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0015179	L-amino acid transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015297	antiporter activity; IBA:GO_Central.
# GO_process	GO:0006461	protein complex assembly; TAS:ProtInc.
# GO_process	GO:0006520	cellular amino acid metabolic process; TAS:ProtInc.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006865	amino acid transport; TAS:Reactome.
# GO_process	GO:0050900	leukocyte migration; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006520	cellular amino acid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0048870	cell motility
# Genevisible	Q92536	HS
# HGNC	HGNC:11064	SLC7A6
# InterPro	IPR002293	AA/rel_permease1
# KEGG_Brite	ko02001	Solute carrier family
# MIM	605641	gene
# Organism	YLAT2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11785	PTHR11785
# PIRSF	PIRSF006060	AA_transporter
# Pfam	PF13520	AA_permease_2
# Proteomes	UP000005640	Chromosome 16
# Reactome	R-HSA-210991	Basigin interactions
# Reactome	R-HSA-352230	Amino acid transport across the plasma membrane
# RecName	YLAT2_HUMAN	Y+L amino acid transporter 2
# RefSeq	NP_001070253	NM_001076785.2
# RefSeq	NP_003974	NM_003983.5
# RefSeq	XP_011521735	XM_011523433.1
# RefSeq	XP_011521736	XM_011523434.1
# RefSeq	XP_011521740	XM_011523438.1
# SEQUENCE CAUTION	Sequence=BAA13376.2; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family. {ECO	0000255}. 
# SUBCELLULAR LOCATION	YLAT2_HUMAN	Basolateral cell membrane {ECO 0000269|PubMed 15756301, ECO 0000269|PubMed 16785209}; Multi- pass membrane protein {ECO 0000269|PubMed 15756301, ECO 0000269|PubMed 16785209}. 
# SUBUNIT	YLAT2_HUMAN	Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc. {ECO 0000269|PubMed 11311135, ECO 0000269|PubMed 16785209}. 
# TCDB	2.A.3.8.23	the amino acid-polyamine-organocation (apc) family
# TISSUE SPECIFICITY	YLAT2_HUMAN	Expressed in normal fibroblasts and those from LPI patients. Also expressed in HUVECs, monocytes, RPE cells, and various carcinoma cell lines. {ECO 0000269|PubMed 11078698, ECO 0000269|PubMed 11742806, ECO 0000269|PubMed 14603368, ECO 0000269|PubMed 15280038, ECO 0000269|PubMed 17197568, ECO 0000269|PubMed 17329401}. 
# UCSC	uc002evt	human
# eggNOG	COG0531	LUCA
# eggNOG	KOG1287	Eukaryota
BLAST	swissprot:YLAT2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:YLAT2_HUMAN
BioCyc	MetaCyc:ENSG00000103064-MONOMER	http://biocyc.org/getid?id=MetaCyc:ENSG00000103064-MONOMER
BioCyc	ZFISH:ENSG00000103064-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000103064-MONOMER
COXPRESdb	9057	http://coxpresdb.jp/data/gene/9057.shtml
CleanEx	HS_SLC7A6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC7A6
DOI	10.1016/j.febslet.2004.06.086	http://dx.doi.org/10.1016/j.febslet.2004.06.086
DOI	10.1038/sj.ejhg.5201376	http://dx.doi.org/10.1038/sj.ejhg.5201376
DOI	10.1042/bj3490787	http://dx.doi.org/10.1042/bj3490787
DOI	10.1074/jbc.273.49.32437	http://dx.doi.org/10.1074/jbc.273.49.32437
DOI	10.1080/09687860600652968	http://dx.doi.org/10.1080/09687860600652968
DOI	10.1093/dnares/3.5.321	http://dx.doi.org/10.1093/dnares/3.5.321
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1113/eph8802647	http://dx.doi.org/10.1113/eph8802647
DOI	10.1152/ajpcell.00323.2006	http://dx.doi.org/10.1152/ajpcell.00323.2006
DOI	10.1167/iovs.06-0398	http://dx.doi.org/10.1167/iovs.06-0398
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	BC028216	http://www.ebi.ac.uk/ena/data/view/BC028216
EMBL	CH471092	http://www.ebi.ac.uk/ena/data/view/CH471092
EMBL	CR749291	http://www.ebi.ac.uk/ena/data/view/CR749291
EMBL	D87432	http://www.ebi.ac.uk/ena/data/view/D87432
Ensembl	ENST00000219343	http://www.ensembl.org/id/ENST00000219343
Ensembl	ENST00000566454	http://www.ensembl.org/id/ENST00000566454
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_function	GO:0015179	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015179
GO_function	GO:0015297	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297
GO_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GO_process	GO:0006520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GO_process	GO:0050900	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050900
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GeneCards	SLC7A6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC7A6
GeneID	9057	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9057
GeneTree	ENSGT00760000119037	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119037
H-InvDB	HIX0013172	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0013172
HGNC	HGNC:11064	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11064
HOGENOM	HOG000098892	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000098892&db=HOGENOM6
HOVERGEN	HBG000476	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000476&db=HOVERGEN
HPA	HPA050713	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA050713
InParanoid	Q92536	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q92536
IntAct	Q92536	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q92536*
InterPro	IPR002293	http://www.ebi.ac.uk/interpro/entry/IPR002293
Jabion	9057	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9057
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:9057	http://www.genome.jp/dbget-bin/www_bget?hsa:9057
KEGG_Orthology	KO:K13872	http://www.genome.jp/dbget-bin/www_bget?KO:K13872
MIM	605641	http://www.ncbi.nlm.nih.gov/omim/605641
OMA	GSSWDVG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GSSWDVG
OrthoDB	EOG091G07EM	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07EM
PANTHER	PTHR11785	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785
PSORT	swissprot:YLAT2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:YLAT2_HUMAN
PSORT-B	swissprot:YLAT2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:YLAT2_HUMAN
PSORT2	swissprot:YLAT2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:YLAT2_HUMAN
Pfam	PF13520	http://pfam.xfam.org/family/PF13520
PharmGKB	PA35924	http://www.pharmgkb.org/do/serve?objId=PA35924&objCls=Gene
Phobius	swissprot:YLAT2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:YLAT2_HUMAN
PhylomeDB	Q92536	http://phylomedb.org/?seqid=Q92536
ProteinModelPortal	Q92536	http://www.proteinmodelportal.org/query/uniprot/Q92536
PubMed	10903140	http://www.ncbi.nlm.nih.gov/pubmed/10903140
PubMed	11078698	http://www.ncbi.nlm.nih.gov/pubmed/11078698
PubMed	11311135	http://www.ncbi.nlm.nih.gov/pubmed/11311135
PubMed	11742806	http://www.ncbi.nlm.nih.gov/pubmed/11742806
PubMed	14603368	http://www.ncbi.nlm.nih.gov/pubmed/14603368
PubMed	15280038	http://www.ncbi.nlm.nih.gov/pubmed/15280038
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15756301	http://www.ncbi.nlm.nih.gov/pubmed/15756301
PubMed	16785209	http://www.ncbi.nlm.nih.gov/pubmed/16785209
PubMed	17197568	http://www.ncbi.nlm.nih.gov/pubmed/17197568
PubMed	17329401	http://www.ncbi.nlm.nih.gov/pubmed/17329401
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	9039502	http://www.ncbi.nlm.nih.gov/pubmed/9039502
PubMed	9829974	http://www.ncbi.nlm.nih.gov/pubmed/9829974
Reactome	R-HSA-210991	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-210991
Reactome	R-HSA-352230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-352230
RefSeq	NP_001070253	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001070253
RefSeq	NP_003974	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003974
RefSeq	XP_011521735	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011521735
RefSeq	XP_011521736	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011521736
RefSeq	XP_011521740	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011521740
STRING	9606.ENSP00000219343	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000219343&targetmode=cogs
TCDB	2.A.3.8.23	http://www.tcdb.org/search/result.php?tc=2.A.3.8.23
UCSC	uc002evt	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002evt&org=rat
UniGene	Hs.679580	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.679580
UniProtKB	YLAT2_HUMAN	http://www.uniprot.org/uniprot/YLAT2_HUMAN
UniProtKB-AC	Q92536	http://www.uniprot.org/uniprot/Q92536
charge	swissprot:YLAT2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:YLAT2_HUMAN
eggNOG	COG0531	http://eggnogapi.embl.de/nog_data/html/tree/COG0531
eggNOG	KOG1287	http://eggnogapi.embl.de/nog_data/html/tree/KOG1287
epestfind	swissprot:YLAT2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:YLAT2_HUMAN
garnier	swissprot:YLAT2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:YLAT2_HUMAN
helixturnhelix	swissprot:YLAT2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:YLAT2_HUMAN
hmoment	swissprot:YLAT2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:YLAT2_HUMAN
iep	swissprot:YLAT2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:YLAT2_HUMAN
inforesidue	swissprot:YLAT2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:YLAT2_HUMAN
neXtProt	NX_Q92536	http://www.nextprot.org/db/entry/NX_Q92536
octanol	swissprot:YLAT2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:YLAT2_HUMAN
pepcoil	swissprot:YLAT2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:YLAT2_HUMAN
pepdigest	swissprot:YLAT2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:YLAT2_HUMAN
pepinfo	swissprot:YLAT2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:YLAT2_HUMAN
pepnet	swissprot:YLAT2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:YLAT2_HUMAN
pepstats	swissprot:YLAT2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:YLAT2_HUMAN
pepwheel	swissprot:YLAT2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:YLAT2_HUMAN
pepwindow	swissprot:YLAT2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:YLAT2_HUMAN
sigcleave	swissprot:YLAT2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:YLAT2_HUMAN
## Database	ID	URL or Descriptions
# AltName	IPO13_HUMAN	Karyopherin-13
# AltName	IPO13_HUMAN	Ran-binding protein 13
# BioGrid	115025	35
# ChiTaRS	IPO13	human
# Ensembl	ENST00000372343	ENSP00000361418; ENSG00000117408
# ExpressionAtlas	O94829	baseline and differential
# FUNCTION	IPO13_HUMAN	Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13. {ECO 0000250, ECO 0000269|PubMed 11447110, ECO 0000269|PubMed 15143176}. 
# GO_component	GO:0005737	cytoplasm; IBA:GO_Central.
# GO_component	GO:0031965	nuclear membrane; IBA:GO_Central.
# GO_function	GO:0008139	nuclear localization sequence binding; IBA:GO_Central.
# GO_function	GO:0008565	protein transporter activity; IBA:GO_Central.
# GO_process	GO:0006606	protein import into nucleus; IDA:MGI.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# Gene3D	1.25.10.10	-; 3.
# Genevisible	O94829	HS
# HGNC	HGNC:16853	IPO13
# INTERACTION	IPO13_HUMAN	Q15699 ALX1; NbExp=2; IntAct=EBI-747310, EBI-750671; Q9UBX2 DUX4; NbExp=2; IntAct=EBI-747310, EBI-11600078; Q6RFH8 DUX4L9; NbExp=2; IntAct=EBI-747310, EBI-11599882; P47813 EIF1AX; NbExp=14; IntAct=EBI-747310, EBI-1045377; P61326 MAGOH; NbExp=4; IntAct=EBI-747310, EBI-299134; Q9BYU1 PBX4; NbExp=5; IntAct=EBI-747310, EBI-10302990; P62826 RAN; NbExp=13; IntAct=EBI-747310, EBI-286642; P63279 UBE2I; NbExp=6; IntAct=EBI-747310, EBI-80168; 
# IntAct	O94829	16
# InterPro	IPR001494	Importin-beta_N
# InterPro	IPR011989	ARM-like
# InterPro	IPR013598	Exportin-1/Importin-b-like
# InterPro	IPR016024	ARM-type_fold
# MIM	610411	gene
# Organism	IPO13_HUMAN	Homo sapiens (Human)
# PDB	2X19	X-ray; 2.80 A; B=1-963
# PDB	2XWU	X-ray; 2.80 A; B=1-963
# PDB	3ZJY	X-ray; 3.60 A; B/E/G=1-963
# PIR	T17276	T17276
# PROSITE	PS50166	IMPORTIN_B_NT
# Pfam	PF03810	IBN_N
# Pfam	PF08389	Xpo1
# Proteomes	UP000005640	Chromosome 1
# RecName	IPO13_HUMAN	Importin-13
# RefSeq	NP_055467	NM_014652.3
# SEQUENCE CAUTION	Sequence=BAA34444.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB14575.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the importin beta family. {ECO	0000305}. 
# SIMILARITY	Contains 1 importin N-terminal domain. {ECO:0000255|PROSITE-ProRule	PRU00115}. 
# SIMILARITY	Contains 20 HEAT repeats. {ECO	0000305}. 
# SMART	SM00913	IBN_N
# SUBCELLULAR LOCATION	IPO13_HUMAN	Cytoplasm. Nucleus. 
# SUBUNIT	IPO13_HUMAN	Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6. {ECO 0000269|PubMed 11447110, ECO 0000269|PubMed 15143176, ECO 0000269|PubMed 20122403, ECO 0000269|PubMed 21139563}. 
# SUPFAM	SSF48371	SSF48371; 2
# TCDB	1.I.1.1	the nuclear pore complex (npc) family
# TISSUE SPECIFICITY	Expressed in fetal brain, heart, intestine and kidney. {ECO:0000269|PubMed	10745026}. 
# UCSC	uc001ckx	human
# eggNOG	ENOG410XT8Y	LUCA
# eggNOG	KOG2022	Eukaryota
BLAST	swissprot:IPO13_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:IPO13_HUMAN
BioCyc	ZFISH:ENSG00000117408-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000117408-MONOMER
COXPRESdb	9670	http://coxpresdb.jp/data/gene/9670.shtml
CleanEx	HS_IPO13	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_IPO13
DOI	10.1016/j.molcel.2010.01.007	http://dx.doi.org/10.1016/j.molcel.2010.01.007
DOI	10.1038/emboj.2010.320	http://dx.doi.org/10.1038/emboj.2010.320
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/dnares/5.5.277	http://dx.doi.org/10.1093/dnares/5.5.277
DOI	10.1093/emboj/20.14.3685	http://dx.doi.org/10.1093/emboj/20.14.3685
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1128/MCB.24.11.4824-4834.2004	http://dx.doi.org/10.1128/MCB.24.11.4824-4834.2004
DOI	10.1165/ajrcmb.22.4.3929	http://dx.doi.org/10.1165/ajrcmb.22.4.3929
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AB018267	http://www.ebi.ac.uk/ena/data/view/AB018267
EMBL	AF267987	http://www.ebi.ac.uk/ena/data/view/AF267987
EMBL	AK023441	http://www.ebi.ac.uk/ena/data/view/AK023441
EMBL	AL117501	http://www.ebi.ac.uk/ena/data/view/AL117501
EMBL	AL357079	http://www.ebi.ac.uk/ena/data/view/AL357079
EMBL	BC008194	http://www.ebi.ac.uk/ena/data/view/BC008194
EMBL	CH471059	http://www.ebi.ac.uk/ena/data/view/CH471059
EMBL	CH471059	http://www.ebi.ac.uk/ena/data/view/CH471059
Ensembl	ENST00000372343	http://www.ensembl.org/id/ENST00000372343
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0031965	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031965
GO_function	GO:0008139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008139
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0006606	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006606
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
GeneCards	IPO13	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=IPO13
GeneID	9670	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9670
GeneTree	ENSGT00530000063347	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063347
HGNC	HGNC:16853	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16853
HOVERGEN	HBG052141	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052141&db=HOVERGEN
HPA	CAB070425	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB070425
InParanoid	O94829	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O94829
IntAct	O94829	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O94829*
InterPro	IPR001494	http://www.ebi.ac.uk/interpro/entry/IPR001494
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR013598	http://www.ebi.ac.uk/interpro/entry/IPR013598
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
Jabion	9670	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9670
KEGG_Gene	hsa:9670	http://www.genome.jp/dbget-bin/www_bget?hsa:9670
MIM	610411	http://www.ncbi.nlm.nih.gov/omim/610411
MINT	MINT-1465082	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1465082
OMA	QMYSTIP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QMYSTIP
OrthoDB	EOG091G01CP	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01CP
PDB	2X19	http://www.ebi.ac.uk/pdbe-srv/view/entry/2X19
PDB	2XWU	http://www.ebi.ac.uk/pdbe-srv/view/entry/2XWU
PDB	3ZJY	http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZJY
PDBsum	2X19	http://www.ebi.ac.uk/pdbsum/2X19
PDBsum	2XWU	http://www.ebi.ac.uk/pdbsum/2XWU
PDBsum	3ZJY	http://www.ebi.ac.uk/pdbsum/3ZJY
PROSITE	PS50166	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50166
PSORT	swissprot:IPO13_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:IPO13_HUMAN
PSORT-B	swissprot:IPO13_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:IPO13_HUMAN
PSORT2	swissprot:IPO13_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:IPO13_HUMAN
Pfam	PF03810	http://pfam.xfam.org/family/PF03810
Pfam	PF08389	http://pfam.xfam.org/family/PF08389
PharmGKB	PA134981096	http://www.pharmgkb.org/do/serve?objId=PA134981096&objCls=Gene
Phobius	swissprot:IPO13_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:IPO13_HUMAN
PhylomeDB	O94829	http://phylomedb.org/?seqid=O94829
ProteinModelPortal	O94829	http://www.proteinmodelportal.org/query/uniprot/O94829
PubMed	10745026	http://www.ncbi.nlm.nih.gov/pubmed/10745026
PubMed	11447110	http://www.ncbi.nlm.nih.gov/pubmed/11447110
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15143176	http://www.ncbi.nlm.nih.gov/pubmed/15143176
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	20122403	http://www.ncbi.nlm.nih.gov/pubmed/20122403
PubMed	21139563	http://www.ncbi.nlm.nih.gov/pubmed/21139563
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	9872452	http://www.ncbi.nlm.nih.gov/pubmed/9872452
RefSeq	NP_055467	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055467
SMART	SM00913	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00913
SMR	O94829	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O94829
STRING	9606.ENSP00000361418	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000361418&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
TCDB	1.I.1.1	http://www.tcdb.org/search/result.php?tc=1.I.1.1
UCSC	uc001ckx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001ckx&org=rat
UniGene	Hs.158497	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.158497
UniProtKB	IPO13_HUMAN	http://www.uniprot.org/uniprot/IPO13_HUMAN
UniProtKB-AC	O94829	http://www.uniprot.org/uniprot/O94829
charge	swissprot:IPO13_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:IPO13_HUMAN
eggNOG	ENOG410XT8Y	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XT8Y
eggNOG	KOG2022	http://eggnogapi.embl.de/nog_data/html/tree/KOG2022
epestfind	swissprot:IPO13_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:IPO13_HUMAN
garnier	swissprot:IPO13_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:IPO13_HUMAN
helixturnhelix	swissprot:IPO13_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:IPO13_HUMAN
hmoment	swissprot:IPO13_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:IPO13_HUMAN
iep	swissprot:IPO13_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:IPO13_HUMAN
inforesidue	swissprot:IPO13_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:IPO13_HUMAN
neXtProt	NX_O94829	http://www.nextprot.org/db/entry/NX_O94829
octanol	swissprot:IPO13_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:IPO13_HUMAN
pepcoil	swissprot:IPO13_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:IPO13_HUMAN
pepdigest	swissprot:IPO13_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:IPO13_HUMAN
pepinfo	swissprot:IPO13_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:IPO13_HUMAN
pepnet	swissprot:IPO13_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:IPO13_HUMAN
pepstats	swissprot:IPO13_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:IPO13_HUMAN
pepwheel	swissprot:IPO13_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:IPO13_HUMAN
pepwindow	swissprot:IPO13_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:IPO13_HUMAN
sigcleave	swissprot:IPO13_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:IPO13_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S4A10_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q6U841-1; Sequence=Displayed; Name=2; IsoId=Q6U841-2; Sequence=VSP_019653; Name=3; IsoId=Q6U841-3; Sequence=VSP_044993, VSP_019653; Note=No experimental confirmation available.; Name=4; IsoId=Q6U841-4; Sequence=VSP_054471, VSP_054472; Note=No experimental confirmation available.; 
# AltName	S4A10_HUMAN	Solute carrier family 4 member 10
# CCDS	CCDS46438	-. [Q6U841-2]
# CCDS	CCDS54411	-. [Q6U841-1]
# CCDS	CCDS54412	-. [Q6U841-3]
# ChiTaRS	SLC4A10	human
# DrugBank	DB01390	Sodium bicarbonate
# Ensembl	ENST00000375514	ENSP00000364664; ENSG00000144290. [Q6U841-3]
# Ensembl	ENST00000415876	ENSP00000395797; ENSG00000144290. [Q6U841-2]
# Ensembl	ENST00000446997	ENSP00000393066; ENSG00000144290. [Q6U841-1]
# ExpressionAtlas	Q6U841	baseline and differential
# FUNCTION	S4A10_HUMAN	Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity). {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:Ensembl.
# GO_component	GO:0043025	neuronal cell body; IEA:Ensembl.
# GO_component	GO:0097440	apical dendrite; IEA:Ensembl.
# GO_component	GO:0097441	basilar dendrite; IEA:Ensembl.
# GO_component	GO:0097442	CA3 pyramidal cell dendrite; IEA:Ensembl.
# GO_function	GO:0005452	inorganic anion exchanger activity; TAS:Reactome.
# GO_function	GO:0008509	anion transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_function	S4A10_HUMAN	GO 0015301 anion anion antiporter activity; IEA Ensembl.
# GO_process	GO:0006814	sodium ion transport; IEA:UniProtKB-KW.
# GO_process	GO:0006821	chloride transport; NAS:UniProtKB.
# GO_process	GO:0007399	nervous system development; IBA:GO_Central.
# GO_process	GO:0009416	response to light stimulus; IEA:Ensembl.
# GO_process	GO:0009791	post-embryonic development; IEA:Ensembl.
# GO_process	GO:0015701	bicarbonate transport; NAS:UniProtKB.
# GO_process	GO:0021860	pyramidal neuron development; IEA:Ensembl.
# GO_process	GO:0035264	multicellular organism growth; IEA:Ensembl.
# GO_process	GO:0035641	locomotory exploration behavior; IEA:Ensembl.
# GO_process	GO:0048854	brain morphogenesis; IEA:Ensembl.
# GO_process	GO:0051453	regulation of intracellular pH; IBA:GO_Central.
# GO_process	GO:0098656	anion transmembrane transport; IBA:GO_Central.
# GO_process	GO:1902600	hydrogen ion transmembrane transport; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0040007	growth
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.1100.10	-; 2.
# HGNC	HGNC:13811	SLC4A10
# IntAct	Q6U841	2
# InterPro	IPR003020	HCO3_transpt_euk
# InterPro	IPR003024	Na/HCO3_transpt
# InterPro	IPR011531	HCO3_transpt_C
# InterPro	IPR013769	Band3_cytoplasmic_dom
# InterPro	IPR016152	PTrfase/Anion_transptr
# KEGG_Brite	ko02001	Solute carrier family
# MIM	605556	gene
# Organism	S4A10_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11453	PTHR11453
# PRINTS	PR01231	HCO3TRNSPORT
# PRINTS	PR01232	NAHCO3TRSPRT
# Pfam	PF00955	HCO3_cotransp
# Pfam	PF07565	Band_3_cyto
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-425381	Bicarbonate transporters
# RecName	S4A10_HUMAN	Sodium-driven chloride bicarbonate exchanger
# RefSeq	NP_001171486	NM_001178015.1. [Q6U841-1]
# RefSeq	NP_001171487	NM_001178016.1. [Q6U841-3]
# RefSeq	NP_071341	NM_022058.3. [Q6U841-2]
# SIMILARITY	Belongs to the anion exchanger (TC 2.A.31) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S4A10_HUMAN	Cell membrane; Multi-pass membrane protein. Note=Localizes to the basolateral membrane. {ECO 0000250}. 
# SUPFAM	SSF55804	SSF55804; 2
# TCDB	2.A.31.2.14	the anion exchanger (ae) family
# TIGRFAMs	TIGR00834	ae
# UCSC	uc002ubx	human. [Q6U841-1]
# eggNOG	ENOG410XPHD	LUCA
# eggNOG	KOG1172	Eukaryota
BLAST	swissprot:S4A10_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S4A10_HUMAN
COXPRESdb	57282	http://coxpresdb.jp/data/gene/57282.shtml
CleanEx	HS_SLC4A10	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC4A10
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.C000456200	http://dx.doi.org/10.1074/jbc.C000456200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DrugBank	DB01390	http://www.drugbank.ca/drugs/DB01390
EMBL	AB040457	http://www.ebi.ac.uk/ena/data/view/AB040457
EMBL	AC008063	http://www.ebi.ac.uk/ena/data/view/AC008063
EMBL	AC009487	http://www.ebi.ac.uk/ena/data/view/AC009487
EMBL	AC062022	http://www.ebi.ac.uk/ena/data/view/AC062022
EMBL	AC092654	http://www.ebi.ac.uk/ena/data/view/AC092654
EMBL	AC092841	http://www.ebi.ac.uk/ena/data/view/AC092841
EMBL	AC096654	http://www.ebi.ac.uk/ena/data/view/AC096654
EMBL	AK293793	http://www.ebi.ac.uk/ena/data/view/AK293793
EMBL	AK294767	http://www.ebi.ac.uk/ena/data/view/AK294767
EMBL	AL713680	http://www.ebi.ac.uk/ena/data/view/AL713680
EMBL	AL832525	http://www.ebi.ac.uk/ena/data/view/AL832525
EMBL	AY376402	http://www.ebi.ac.uk/ena/data/view/AY376402
EMBL	BC136269	http://www.ebi.ac.uk/ena/data/view/BC136269
EMBL	BC143714	http://www.ebi.ac.uk/ena/data/view/BC143714
EMBL	CH471058	http://www.ebi.ac.uk/ena/data/view/CH471058
Ensembl	ENST00000375514	http://www.ensembl.org/id/ENST00000375514
Ensembl	ENST00000415876	http://www.ensembl.org/id/ENST00000415876
Ensembl	ENST00000446997	http://www.ensembl.org/id/ENST00000446997
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0097440	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097440
GO_component	GO:0097441	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097441
GO_component	GO:0097442	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097442
GO_function	GO:0005452	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005452
GO_function	GO:0008509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008509
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_function	GO:0015301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015301
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0006821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006821
GO_process	GO:0007399	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007399
GO_process	GO:0009416	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009416
GO_process	GO:0009791	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009791
GO_process	GO:0015701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015701
GO_process	GO:0021860	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021860
GO_process	GO:0035264	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035264
GO_process	GO:0035641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035641
GO_process	GO:0048854	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048854
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GO_process	GO:0098656	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098656
GO_process	GO:1902600	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902600
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0040007	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040007
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.1100.10	http://www.cathdb.info/version/latest/superfamily/3.40.1100.10
GeneCards	SLC4A10	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC4A10
GeneID	57282	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57282
GeneTree	ENSGT00760000119021	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119021
HGNC	HGNC:13811	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13811
HOGENOM	HOG000280684	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280684&db=HOGENOM6
HOVERGEN	HBG004326	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004326&db=HOVERGEN
HPA	HPA034755	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA034755
InParanoid	Q6U841	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6U841
IntAct	Q6U841	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q6U841*
InterPro	IPR003020	http://www.ebi.ac.uk/interpro/entry/IPR003020
InterPro	IPR003024	http://www.ebi.ac.uk/interpro/entry/IPR003024
InterPro	IPR011531	http://www.ebi.ac.uk/interpro/entry/IPR011531
InterPro	IPR013769	http://www.ebi.ac.uk/interpro/entry/IPR013769
InterPro	IPR016152	http://www.ebi.ac.uk/interpro/entry/IPR016152
Jabion	57282	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=57282
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:57282	http://www.genome.jp/dbget-bin/www_bget?hsa:57282
KEGG_Orthology	KO:K13861	http://www.genome.jp/dbget-bin/www_bget?KO:K13861
MIM	605556	http://www.ncbi.nlm.nih.gov/omim/605556
OMA	RIFGGMI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RIFGGMI
OrthoDB	EOG091G01FT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01FT
PANTHER	PTHR11453	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11453
PRINTS	PR01231	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01231
PRINTS	PR01232	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01232
PSORT	swissprot:S4A10_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S4A10_HUMAN
PSORT-B	swissprot:S4A10_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S4A10_HUMAN
PSORT2	swissprot:S4A10_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S4A10_HUMAN
Pfam	PF00955	http://pfam.xfam.org/family/PF00955
Pfam	PF07565	http://pfam.xfam.org/family/PF07565
PharmGKB	PA37810	http://www.pharmgkb.org/do/serve?objId=PA37810&objCls=Gene
Phobius	swissprot:S4A10_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S4A10_HUMAN
PhylomeDB	Q6U841	http://phylomedb.org/?seqid=Q6U841
ProteinModelPortal	Q6U841	http://www.proteinmodelportal.org/query/uniprot/Q6U841
PubMed	10993873	http://www.ncbi.nlm.nih.gov/pubmed/10993873
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
Reactome	R-HSA-425381	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425381
RefSeq	NP_001171486	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001171486
RefSeq	NP_001171487	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001171487
RefSeq	NP_071341	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_071341
STRING	9606.ENSP00000393066	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000393066&targetmode=cogs
SUPFAM	SSF55804	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55804
TCDB	2.A.31.2.14	http://www.tcdb.org/search/result.php?tc=2.A.31.2.14
TIGRFAMs	TIGR00834	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00834
UCSC	uc002ubx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ubx&org=rat
UniGene	Hs.333958	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.333958
UniProtKB	S4A10_HUMAN	http://www.uniprot.org/uniprot/S4A10_HUMAN
UniProtKB-AC	Q6U841	http://www.uniprot.org/uniprot/Q6U841
charge	swissprot:S4A10_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S4A10_HUMAN
eggNOG	ENOG410XPHD	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPHD
eggNOG	KOG1172	http://eggnogapi.embl.de/nog_data/html/tree/KOG1172
epestfind	swissprot:S4A10_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S4A10_HUMAN
garnier	swissprot:S4A10_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S4A10_HUMAN
helixturnhelix	swissprot:S4A10_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S4A10_HUMAN
hmoment	swissprot:S4A10_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S4A10_HUMAN
iep	swissprot:S4A10_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S4A10_HUMAN
inforesidue	swissprot:S4A10_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S4A10_HUMAN
neXtProt	NX_Q6U841	http://www.nextprot.org/db/entry/NX_Q6U841
octanol	swissprot:S4A10_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S4A10_HUMAN
pepcoil	swissprot:S4A10_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S4A10_HUMAN
pepdigest	swissprot:S4A10_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S4A10_HUMAN
pepinfo	swissprot:S4A10_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S4A10_HUMAN
pepnet	swissprot:S4A10_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S4A10_HUMAN
pepstats	swissprot:S4A10_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S4A10_HUMAN
pepwheel	swissprot:S4A10_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S4A10_HUMAN
pepwindow	swissprot:S4A10_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S4A10_HUMAN
sigcleave	swissprot:S4A10_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S4A10_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S22A9_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8IVM8-1; Sequence=Displayed; Name=2; IsoId=Q8IVM8-2; Sequence=VSP_036710, VSP_036711; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 
# AltName	S22A9_HUMAN	Organic anion transporter 7
# BioGrid	125322	65
# CCDS	CCDS8043	-. [Q8IVM8-1]
# CDD	cd06174	MFS
# DEVELOPMENTAL STAGE	Expressed in fetal liver. {ECO:0000269|PubMed	17393504}. 
# Ensembl	ENST00000279178	ENSP00000279178; ENSG00000149742. [Q8IVM8-1]
# Ensembl	ENST00000536333	ENSP00000440206; ENSG00000149742. [Q8IVM8-2]
# FUNCTION	S22A9_HUMAN	Sodium-independent organic anion transporter which exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones. It is also specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate, butyrate and valerate. May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs at the sinusoidal membrane of hepatocytes. {ECO 0000269|PubMed 17393504}. 
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016323	basolateral plasma membrane; IDA:UniProtKB.
# GO_function	GO:0005452	inorganic anion exchanger activity; IBA:GO_Central.
# GO_function	GO:0015347	sodium-independent organic anion transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015636	short-chain fatty acid uptake transporter activity; IDA:UniProtKB.
# GO_function	S22A9_HUMAN	GO 0015301 anion anion antiporter activity; IDA UniProtKB.
# GO_process	GO:0009914	hormone transport; IDA:UniProtKB.
# GO_process	GO:0015913	short-chain fatty acid import; IDA:UniProtKB.
# GO_process	GO:0043252	sodium-independent organic anion transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q8IVM8	HS
# HGNC	HGNC:16261	SLC22A9
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	607579	gene
# Organism	S22A9_HUMAN	Homo sapiens (Human)
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 11
# RecName	S22A9_HUMAN	Solute carrier family 22 member 9
# RefSeq	NP_543142	NM_080866.2. [Q8IVM8-1]
# SIMILARITY	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S22A9_HUMAN	Basolateral cell membrane {ECO 0000269|PubMed 17393504}; Multi-pass membrane protein {ECO 0000269|PubMed 17393504}. Note=Enriched at the sinusoidal part of the plasma membrane. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.19.18	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	S22A9_HUMAN	Specifically expressed in liver by hepatocytes (at protein level). {ECO 0000269|PubMed 11327718, ECO 0000269|PubMed 17393504}. 
# UCSC	uc001nww	human. [Q8IVM8-1]
# eggNOG	COG0477	LUCA
# eggNOG	KOG0255	Eukaryota
BLAST	swissprot:S22A9_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S22A9_HUMAN
COXPRESdb	114571	http://coxpresdb.jp/data/gene/114571.shtml
CleanEx	HS_SLC22A9	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC22A9
DOI	10.1002/hep.21596	http://dx.doi.org/10.1002/hep.21596
DOI	10.1006/bbrc.2001.4774	http://dx.doi.org/10.1006/bbrc.2001.4774
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
EMBL	AB062418	http://www.ebi.ac.uk/ena/data/view/AB062418
EMBL	AB074812	http://www.ebi.ac.uk/ena/data/view/AB074812
EMBL	AF440402	http://www.ebi.ac.uk/ena/data/view/AF440402
EMBL	AJ295270	http://www.ebi.ac.uk/ena/data/view/AJ295270
EMBL	AK074246	http://www.ebi.ac.uk/ena/data/view/AK074246
EMBL	AP000484	http://www.ebi.ac.uk/ena/data/view/AP000484
EMBL	AP001880	http://www.ebi.ac.uk/ena/data/view/AP001880
EMBL	BC022379	http://www.ebi.ac.uk/ena/data/view/BC022379
EMBL	BC126288	http://www.ebi.ac.uk/ena/data/view/BC126288
EMBL	CH471076	http://www.ebi.ac.uk/ena/data/view/CH471076
EMBL	CH471076	http://www.ebi.ac.uk/ena/data/view/CH471076
Ensembl	ENST00000279178	http://www.ensembl.org/id/ENST00000279178
Ensembl	ENST00000536333	http://www.ensembl.org/id/ENST00000536333
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_function	GO:0005452	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005452
GO_function	GO:0015301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015301
GO_function	GO:0015347	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015347
GO_function	GO:0015636	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015636
GO_process	GO:0009914	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009914
GO_process	GO:0015913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015913
GO_process	GO:0043252	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043252
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC22A9	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC22A9
GeneID	114571	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=114571
GeneTree	ENSGT00760000118852	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118852
HGNC	HGNC:16261	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16261
HOGENOM	HOG000234569	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234569&db=HOGENOM6
HOVERGEN	HBG108433	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108433&db=HOVERGEN
InParanoid	Q8IVM8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8IVM8
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	114571	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=114571
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:114571	http://www.genome.jp/dbget-bin/www_bget?hsa:114571
KEGG_Orthology	KO:K08206	http://www.genome.jp/dbget-bin/www_bget?KO:K08206
MIM	607579	http://www.ncbi.nlm.nih.gov/omim/607579
OMA	CKRISLL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CKRISLL
OrthoDB	EOG091G04GS	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G04GS
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:S22A9_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S22A9_HUMAN
PSORT-B	swissprot:S22A9_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S22A9_HUMAN
PSORT2	swissprot:S22A9_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S22A9_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA38102	http://www.pharmgkb.org/do/serve?objId=PA38102&objCls=Gene
Phobius	swissprot:S22A9_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S22A9_HUMAN
PhylomeDB	Q8IVM8	http://phylomedb.org/?seqid=Q8IVM8
ProteinModelPortal	Q8IVM8	http://www.proteinmodelportal.org/query/uniprot/Q8IVM8
PubMed	11327718	http://www.ncbi.nlm.nih.gov/pubmed/11327718
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	17393504	http://www.ncbi.nlm.nih.gov/pubmed/17393504
RefSeq	NP_543142	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_543142
STRING	9606.ENSP00000279178	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000279178&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.19.18	http://www.tcdb.org/search/result.php?tc=2.A.1.19.18
UCSC	uc001nww	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001nww&org=rat
UniGene	Hs.502772	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.502772
UniProtKB	S22A9_HUMAN	http://www.uniprot.org/uniprot/S22A9_HUMAN
UniProtKB-AC	Q8IVM8	http://www.uniprot.org/uniprot/Q8IVM8
charge	swissprot:S22A9_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S22A9_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG0255	http://eggnogapi.embl.de/nog_data/html/tree/KOG0255
epestfind	swissprot:S22A9_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S22A9_HUMAN
garnier	swissprot:S22A9_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S22A9_HUMAN
helixturnhelix	swissprot:S22A9_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S22A9_HUMAN
hmoment	swissprot:S22A9_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S22A9_HUMAN
iep	swissprot:S22A9_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S22A9_HUMAN
inforesidue	swissprot:S22A9_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S22A9_HUMAN
neXtProt	NX_Q8IVM8	http://www.nextprot.org/db/entry/NX_Q8IVM8
octanol	swissprot:S22A9_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S22A9_HUMAN
pepcoil	swissprot:S22A9_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S22A9_HUMAN
pepdigest	swissprot:S22A9_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S22A9_HUMAN
pepinfo	swissprot:S22A9_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S22A9_HUMAN
pepnet	swissprot:S22A9_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S22A9_HUMAN
pepstats	swissprot:S22A9_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S22A9_HUMAN
pepwheel	swissprot:S22A9_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S22A9_HUMAN
pepwindow	swissprot:S22A9_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S22A9_HUMAN
sigcleave	swissprot:S22A9_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S22A9_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	MRS2_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9HD23-1; Sequence=Displayed; Name=2; IsoId=Q9HD23-2; Sequence=VSP_016209, VSP_016210; Name=3; IsoId=Q9HD23-3; Sequence=VSP_016207, VSP_016208; Note=No experimental confirmation available.; Name=4; IsoId=Q9HD23-4; Sequence=VSP_055287; Note=No experimental confirmation available.; 
# AltName	MRS2_HUMAN	MRS2-like protein
# BioGrid	121498	33
# CCDS	CCDS4552	-. [Q9HD23-1]
# CCDS	CCDS69055	-. [Q9HD23-4]
# CCDS	CCDS75408	-. [Q9HD23-2]
# ChiTaRS	MRS2	human
# Ensembl	ENST00000378353	ENSP00000367604; ENSG00000124532. [Q9HD23-2]
# Ensembl	ENST00000378386	ENSP00000367637; ENSG00000124532. [Q9HD23-1]
# Ensembl	ENST00000443868	ENSP00000399585; ENSG00000124532. [Q9HD23-4]
# ExpressionAtlas	Q9HD23	baseline and differential
# FUNCTION	MRS2_HUMAN	Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix (PubMed 11401429, PubMed 18384665). Required for normal expression of the mitochondrial respiratory complex I subunits (PubMed 18384665). {ECO 0000269|PubMed 11401429, ECO 0000269|PubMed 18384665}. 
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015095	magnesium ion transmembrane transporter activity; IMP:UniProtKB.
# GO_process	GO:0045016	mitochondrial magnesium ion transport; IBA:GO_Central.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GO_process	GO:1990614	mitochondrial magnesium ion transmembrane transport; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9HD23	HS
# HGNC	HGNC:13785	MRS2
# IntAct	Q9HD23	3
# KEGG_Brite	ko02000	Transporters
# MISCELLANEOUS	MRS2_HUMAN	Has the ability to complement a deletion of MRS2 in S.cerevisiae and partly restore mitochondrial magnesium concentrations. 
# Organism	MRS2_HUMAN	Homo sapiens (Human)
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-5223345	Miscellaneous transport and binding events
# RecName	MRS2_HUMAN	Magnesium transporter MRS2 homolog, mitochondrial
# RefSeq	NP_001273193	NM_001286264.1. [Q9HD23-4]
# RefSeq	NP_001273194	NM_001286265.1. [Q9HD23-2]
# RefSeq	NP_001273195	NM_001286266.1
# RefSeq	NP_065713	NM_020662.3. [Q9HD23-1]
# SEQUENCE CAUTION	Sequence=CAI17109.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	MRS2_HUMAN	Mitochondrion inner membrane {ECO 0000269|PubMed 11401429, ECO 0000305|PubMed 18384665}; Multi- pass membrane protein {ECO 0000305}. 
# UCSC	uc003nea	human. [Q9HD23-1]
# eggNOG	ENOG410XNNZ	LUCA
# eggNOG	KOG2662	Eukaryota
BLAST	swissprot:MRS2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MRS2_HUMAN
BioCyc	ZFISH:ENSG00000124532-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000124532-MONOMER
COXPRESdb	57380	http://coxpresdb.jp/data/gene/57380.shtml
CleanEx	HS_MRS2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_MRS2
DOI	10.1006/geno.2000.6407	http://dx.doi.org/10.1006/geno.2000.6407
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1582-4934.2008.00328.x	http://dx.doi.org/10.1111/j.1582-4934.2008.00328.x
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
EMBL	AF288288	http://www.ebi.ac.uk/ena/data/view/AF288288
EMBL	AF293076	http://www.ebi.ac.uk/ena/data/view/AF293076
EMBL	AF293078	http://www.ebi.ac.uk/ena/data/view/AF293078
EMBL	AK054587	http://www.ebi.ac.uk/ena/data/view/AK054587
EMBL	AK291058	http://www.ebi.ac.uk/ena/data/view/AK291058
EMBL	AK298849	http://www.ebi.ac.uk/ena/data/view/AK298849
EMBL	AL359713	http://www.ebi.ac.uk/ena/data/view/AL359713
EMBL	AL359713	http://www.ebi.ac.uk/ena/data/view/AL359713
EMBL	AL359713	http://www.ebi.ac.uk/ena/data/view/AL359713
EMBL	BC001028	http://www.ebi.ac.uk/ena/data/view/BC001028
EMBL	BC069009	http://www.ebi.ac.uk/ena/data/view/BC069009
EMBL	CH471087	http://www.ebi.ac.uk/ena/data/view/CH471087
EMBL	CH471087	http://www.ebi.ac.uk/ena/data/view/CH471087
Ensembl	ENST00000378353	http://www.ensembl.org/id/ENST00000378353
Ensembl	ENST00000378386	http://www.ensembl.org/id/ENST00000378386
Ensembl	ENST00000443868	http://www.ensembl.org/id/ENST00000443868
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015095
GO_process	GO:0045016	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045016
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GO_process	GO:1990614	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990614
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	MRS2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=MRS2
GeneID	57380	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57380
GeneTree	ENSGT00390000009988	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000009988
HGNC	HGNC:13785	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13785
HOGENOM	HOG000013083	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000013083&db=HOGENOM6
HOVERGEN	HBG103267	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG103267&db=HOVERGEN
HPA	HPA017642	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA017642
InParanoid	Q9HD23	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9HD23
IntAct	Q9HD23	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9HD23*
Jabion	57380	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=57380
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:57380	http://www.genome.jp/dbget-bin/www_bget?hsa:57380
KEGG_Orthology	KO:K16075	http://www.genome.jp/dbget-bin/www_bget?KO:K16075
OMA	TYPLPFE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TYPLPFE
OrthoDB	EOG091G094B	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G094B
PSORT	swissprot:MRS2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MRS2_HUMAN
PSORT-B	swissprot:MRS2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MRS2_HUMAN
PSORT2	swissprot:MRS2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MRS2_HUMAN
PharmGKB	PA162396189	http://www.pharmgkb.org/do/serve?objId=PA162396189&objCls=Gene
Phobius	swissprot:MRS2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MRS2_HUMAN
PhylomeDB	Q9HD23	http://phylomedb.org/?seqid=Q9HD23
ProteinModelPortal	Q9HD23	http://www.proteinmodelportal.org/query/uniprot/Q9HD23
PubMed	11401429	http://www.ncbi.nlm.nih.gov/pubmed/11401429
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18384665	http://www.ncbi.nlm.nih.gov/pubmed/18384665
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
Reactome	R-HSA-5223345	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5223345
RefSeq	NP_001273193	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273193
RefSeq	NP_001273194	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273194
RefSeq	NP_001273195	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273195
RefSeq	NP_065713	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_065713
SMR	Q9HD23	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9HD23
STRING	9606.ENSP00000367637	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000367637&targetmode=cogs
UCSC	uc003nea	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003nea&org=rat
UniGene	Hs.658612	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.658612
UniGene	Hs.732395	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.732395
UniProtKB	MRS2_HUMAN	http://www.uniprot.org/uniprot/MRS2_HUMAN
UniProtKB-AC	Q9HD23	http://www.uniprot.org/uniprot/Q9HD23
charge	swissprot:MRS2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MRS2_HUMAN
eggNOG	ENOG410XNNZ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNNZ
eggNOG	KOG2662	http://eggnogapi.embl.de/nog_data/html/tree/KOG2662
epestfind	swissprot:MRS2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MRS2_HUMAN
garnier	swissprot:MRS2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MRS2_HUMAN
helixturnhelix	swissprot:MRS2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MRS2_HUMAN
hmoment	swissprot:MRS2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MRS2_HUMAN
iep	swissprot:MRS2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MRS2_HUMAN
inforesidue	swissprot:MRS2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MRS2_HUMAN
neXtProt	NX_Q9HD23	http://www.nextprot.org/db/entry/NX_Q9HD23
octanol	swissprot:MRS2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MRS2_HUMAN
pepcoil	swissprot:MRS2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MRS2_HUMAN
pepdigest	swissprot:MRS2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MRS2_HUMAN
pepinfo	swissprot:MRS2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MRS2_HUMAN
pepnet	swissprot:MRS2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MRS2_HUMAN
pepstats	swissprot:MRS2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MRS2_HUMAN
pepwheel	swissprot:MRS2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MRS2_HUMAN
pepwindow	swissprot:MRS2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MRS2_HUMAN
sigcleave	swissprot:MRS2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MRS2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ACHA3_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=2; IsoId=P32297-2; Sequence=Displayed; Name=1; IsoId=P32297-1; Sequence=VSP_037750; Name=3; IsoId=P32297-3; Sequence=VSP_037751; 
# BioGrid	107558	28
# CCDS	CCDS10305	-. [P32297-2]
# CCDS	CCDS53964	-. [P32297-3]
# ChiTaRS	CHRNA3	human
# DrugBank	DB00184	Nicotine
# DrugBank	DB00514	Dextromethorphan
# DrugBank	DB00674	Galantamine
# DrugBank	DB00898	Ethanol
# DrugBank	DB01090	Pentolinium
# DrugBank	DB01156	Bupropion
# DrugBank	DB01227	Levomethadyl Acetate
# DrugBank	DB01273	Varenicline
# DrugBank	DB09028	Cytisine
# Ensembl	ENST00000326828	ENSP00000315602; ENSG00000080644. [P32297-2]
# Ensembl	ENST00000348639	ENSP00000267951; ENSG00000080644. [P32297-3]
# Ensembl	ENST00000559658	ENSP00000452896; ENSG00000080644. [P32297-2]
# ExpressionAtlas	P32297	baseline and differential
# FUNCTION	ACHA3_HUMAN	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005892	acetylcholine-gated channel complex; IDA:UniProtKB.
# GO_component	GO:0014069	postsynaptic density; ISS:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030425	dendrite; ISS:UniProtKB.
# GO_component	GO:0043025	neuronal cell body; ISS:UniProtKB.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0004889	acetylcholine-activated cation-selective channel activity; IDA:UniProtKB.
# GO_function	GO:0015276	ligand-gated ion channel activity; TAS:DFLAT.
# GO_function	GO:0015464	acetylcholine receptor activity; IDA:UniProtKB.
# GO_function	GO:0042166	acetylcholine binding; IC:UniProtKB.
# GO_process	GO:0006811	ion transport; NAS:UniProtKB.
# GO_process	GO:0006940	regulation of smooth muscle contraction; ISS:UniProtKB.
# GO_process	GO:0007165	signal transduction; IDA:UniProtKB.
# GO_process	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity; ISS:UniProtKB.
# GO_process	GO:0007271	synaptic transmission, cholinergic; ISS:UniProtKB.
# GO_process	GO:0007399	nervous system development; IMP:UniProtKB.
# GO_process	GO:0007626	locomotory behavior; ISS:UniProtKB.
# GO_process	GO:0014056	regulation of acetylcholine secretion, neurotransmission; ISS:UniProtKB.
# GO_process	GO:0035095	behavioral response to nicotine; IMP:UniProtKB.
# GO_process	GO:0042391	regulation of membrane potential; ISS:UniProtKB.
# GO_process	GO:0048814	regulation of dendrite morphogenesis; ISS:UniProtKB.
# GO_process	GO:0060079	excitatory postsynaptic potential; ISS:UniProtKB.
# GO_process	GO:0060084	synaptic transmission involved in micturition; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# Gene3D	1.20.120.370	-; 2.
# Gene3D	2.70.170.10	-; 1.
# Genevisible	P32297	HS
# HGNC	HGNC:1957	CHRNA3
# IntAct	P32297	2
# InterPro	IPR002394	Nicotinic_acetylcholine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# InterPro	IPR027361	Acetylcholine_rcpt_TM
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04725	Cholinergic synapse
# MIM	118503	gene
# MIM	612052	phenotype
# Organism	ACHA3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR18945	PTHR18945; 2
# PDB	4ZK4	X-ray; 1.90 A; A/B/C/D/E=215-230
# PDB	5SYO	X-ray; 2.00 A; A/B/C/D/E=215-230
# PIR	A37040	A37040
# PIR	A53956	A53956
# POLYMORPHISM	Genetic variations in CHRNA3 have been associated with susceptibility to smoking-related behavioral traits and lung cancer, contributing to the smoking quantitative trait locus 3 (SQTL3) [MIM	612052]. 
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00254	NICOTINICR
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 15
# Reactome	R-HSA-629587	Highly sodium permeable acetylcholine nicotinic receptors
# Reactome	R-HSA-629594	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
# Reactome	R-HSA-629597	Highly calcium permeable nicotinic acetylcholine receptors
# RecName	ACHA3_HUMAN	Neuronal acetylcholine receptor subunit alpha-3
# RefSeq	NP_000734	NM_000743.4. [P32297-2]
# RefSeq	NP_001160166	NM_001166694.1. [P32297-3]
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 3/CHRNA3 sub-subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	ACHA3_HUMAN	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Neuronal AChR is composed of two different types of subunits: alpha and beta. Alpha-3 subunit can be combined to beta- 2 or beta-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly. {ECO	0000269|PubMed:16120769}. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TIGRFAMs	TIGR00860	LIC
# UCSC	uc002beb	human. [P32297-2]
# eggNOG	ENOG410XQGR	LUCA
# eggNOG	KOG3645	Eukaryota
BLAST	swissprot:ACHA3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ACHA3_HUMAN
BioCyc	ZFISH:ENSG00000080644-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000080644-MONOMER
COXPRESdb	1136	http://coxpresdb.jp/data/gene/1136.shtml
CleanEx	HS_CHRNA3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CHRNA3
DOI	10.1007/BF02736842	http://dx.doi.org/10.1007/BF02736842
DOI	10.1007/s004390050885	http://dx.doi.org/10.1007/s004390050885
DOI	10.1007/s100380170054	http://dx.doi.org/10.1007/s100380170054
DOI	10.1016/0014-4886(91)90004-V	http://dx.doi.org/10.1016/0014-4886(91)90004-V
DOI	10.1016/0304-3940(90)90287-J	http://dx.doi.org/10.1016/0304-3940(90)90287-J
DOI	10.1016/S0014-5793(96)01383-X	http://dx.doi.org/10.1016/S0014-5793(96)01383-X
DOI	10.1038/452537a	http://dx.doi.org/10.1038/452537a
DOI	10.1038/nature04601	http://dx.doi.org/10.1038/nature04601
DOI	10.1038/nature06846	http://dx.doi.org/10.1038/nature06846
DOI	10.1038/nature06885	http://dx.doi.org/10.1038/nature06885
DOI	10.1038/ng.109	http://dx.doi.org/10.1038/ng.109
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1124/mol.105.017459	http://dx.doi.org/10.1124/mol.105.017459
DrugBank	DB00184	http://www.drugbank.ca/drugs/DB00184
DrugBank	DB00514	http://www.drugbank.ca/drugs/DB00514
DrugBank	DB00674	http://www.drugbank.ca/drugs/DB00674
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01090	http://www.drugbank.ca/drugs/DB01090
DrugBank	DB01156	http://www.drugbank.ca/drugs/DB01156
DrugBank	DB01227	http://www.drugbank.ca/drugs/DB01227
DrugBank	DB01273	http://www.drugbank.ca/drugs/DB01273
DrugBank	DB09028	http://www.drugbank.ca/drugs/DB09028
EMBL	AC027228	http://www.ebi.ac.uk/ena/data/view/AC027228
EMBL	AC067863	http://www.ebi.ac.uk/ena/data/view/AC067863
EMBL	AF385584	http://www.ebi.ac.uk/ena/data/view/AF385584
EMBL	AJ007783	http://www.ebi.ac.uk/ena/data/view/AJ007783
EMBL	AJ007784	http://www.ebi.ac.uk/ena/data/view/AJ007784
EMBL	AJ007785	http://www.ebi.ac.uk/ena/data/view/AJ007785
EMBL	AJ007786	http://www.ebi.ac.uk/ena/data/view/AJ007786
EMBL	AJ007787	http://www.ebi.ac.uk/ena/data/view/AJ007787
EMBL	BC000513	http://www.ebi.ac.uk/ena/data/view/BC000513
EMBL	BC001642	http://www.ebi.ac.uk/ena/data/view/BC001642
EMBL	BC002996	http://www.ebi.ac.uk/ena/data/view/BC002996
EMBL	BC006114	http://www.ebi.ac.uk/ena/data/view/BC006114
EMBL	BC098443	http://www.ebi.ac.uk/ena/data/view/BC098443
EMBL	BT006646	http://www.ebi.ac.uk/ena/data/view/BT006646
EMBL	BT006897	http://www.ebi.ac.uk/ena/data/view/BT006897
EMBL	M37981	http://www.ebi.ac.uk/ena/data/view/M37981
EMBL	M86383	http://www.ebi.ac.uk/ena/data/view/M86383
EMBL	U62432	http://www.ebi.ac.uk/ena/data/view/U62432
EMBL	X53559	http://www.ebi.ac.uk/ena/data/view/X53559
EMBL	Y08418	http://www.ebi.ac.uk/ena/data/view/Y08418
Ensembl	ENST00000326828	http://www.ensembl.org/id/ENST00000326828
Ensembl	ENST00000348639	http://www.ensembl.org/id/ENST00000348639
Ensembl	ENST00000559658	http://www.ensembl.org/id/ENST00000559658
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005892	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005892
GO_component	GO:0014069	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014069
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0004889	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004889
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_function	GO:0015464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015464
GO_function	GO:0042166	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042166
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006940	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006940
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007171
GO_process	GO:0007271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007271
GO_process	GO:0007399	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007399
GO_process	GO:0007626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007626
GO_process	GO:0014056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014056
GO_process	GO:0035095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035095
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0048814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048814
GO_process	GO:0060079	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060079
GO_process	GO:0060084	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060084
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
Gene3D	1.20.120.370	http://www.cathdb.info/version/latest/superfamily/1.20.120.370
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	CHRNA3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CHRNA3
GeneID	1136	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1136
GeneTree	ENSGT00760000118930	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118930
H-InvDB	HIX0017542	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0017542
HGNC	HGNC:1957	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1957
HOVERGEN	HBG003756	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003756&db=HOVERGEN
HPA	HPA029430	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA029430
InParanoid	P32297	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32297
IntAct	P32297	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32297*
InterPro	IPR002394	http://www.ebi.ac.uk/interpro/entry/IPR002394
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
InterPro	IPR027361	http://www.ebi.ac.uk/interpro/entry/IPR027361
Jabion	1136	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1136
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:1136	http://www.genome.jp/dbget-bin/www_bget?hsa:1136
KEGG_Orthology	KO:K04805	http://www.genome.jp/dbget-bin/www_bget?KO:K04805
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04725	http://www.genome.jp/kegg-bin/show_pathway?ko04725
MIM	118503	http://www.ncbi.nlm.nih.gov/omim/118503
MIM	612052	http://www.ncbi.nlm.nih.gov/omim/612052
OMA	NEGNAQK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NEGNAQK
OrthoDB	EOG091G0R20	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0R20
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PDB	4ZK4	http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZK4
PDB	5SYO	http://www.ebi.ac.uk/pdbe-srv/view/entry/5SYO
PDBsum	4ZK4	http://www.ebi.ac.uk/pdbsum/4ZK4
PDBsum	5SYO	http://www.ebi.ac.uk/pdbsum/5SYO
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00254	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00254
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:ACHA3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ACHA3_HUMAN
PSORT-B	swissprot:ACHA3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ACHA3_HUMAN
PSORT2	swissprot:ACHA3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ACHA3_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA113	http://www.pharmgkb.org/do/serve?objId=PA113&objCls=Gene
Phobius	swissprot:ACHA3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ACHA3_HUMAN
PhylomeDB	P32297	http://phylomedb.org/?seqid=P32297
ProteinModelPortal	P32297	http://www.proteinmodelportal.org/query/uniprot/P32297
PubMed	11450844	http://www.ncbi.nlm.nih.gov/pubmed/11450844
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16120769	http://www.ncbi.nlm.nih.gov/pubmed/16120769
PubMed	16572171	http://www.ncbi.nlm.nih.gov/pubmed/16572171
PubMed	18385676	http://www.ncbi.nlm.nih.gov/pubmed/18385676
PubMed	18385720	http://www.ncbi.nlm.nih.gov/pubmed/18385720
PubMed	18385738	http://www.ncbi.nlm.nih.gov/pubmed/18385738
PubMed	18385739	http://www.ncbi.nlm.nih.gov/pubmed/18385739
PubMed	1989896	http://www.ncbi.nlm.nih.gov/pubmed/1989896
PubMed	2336208	http://www.ncbi.nlm.nih.gov/pubmed/2336208
PubMed	8906617	http://www.ncbi.nlm.nih.gov/pubmed/8906617
PubMed	9009220	http://www.ncbi.nlm.nih.gov/pubmed/9009220
PubMed	9921897	http://www.ncbi.nlm.nih.gov/pubmed/9921897
Reactome	R-HSA-629587	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-629587
Reactome	R-HSA-629594	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-629594
Reactome	R-HSA-629597	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-629597
RefSeq	NP_000734	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000734
RefSeq	NP_001160166	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001160166
SMR	P32297	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32297
STRING	9606.ENSP00000315602	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000315602&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc002beb	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002beb&org=rat
UniGene	Hs.89605	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.89605
UniProtKB	ACHA3_HUMAN	http://www.uniprot.org/uniprot/ACHA3_HUMAN
UniProtKB-AC	P32297	http://www.uniprot.org/uniprot/P32297
charge	swissprot:ACHA3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ACHA3_HUMAN
eggNOG	ENOG410XQGR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQGR
eggNOG	KOG3645	http://eggnogapi.embl.de/nog_data/html/tree/KOG3645
epestfind	swissprot:ACHA3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ACHA3_HUMAN
garnier	swissprot:ACHA3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ACHA3_HUMAN
helixturnhelix	swissprot:ACHA3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACHA3_HUMAN
hmoment	swissprot:ACHA3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ACHA3_HUMAN
iep	swissprot:ACHA3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ACHA3_HUMAN
inforesidue	swissprot:ACHA3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ACHA3_HUMAN
neXtProt	NX_P32297	http://www.nextprot.org/db/entry/NX_P32297
octanol	swissprot:ACHA3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ACHA3_HUMAN
pepcoil	swissprot:ACHA3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ACHA3_HUMAN
pepdigest	swissprot:ACHA3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ACHA3_HUMAN
pepinfo	swissprot:ACHA3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ACHA3_HUMAN
pepnet	swissprot:ACHA3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ACHA3_HUMAN
pepstats	swissprot:ACHA3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ACHA3_HUMAN
pepwheel	swissprot:ACHA3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ACHA3_HUMAN
pepwindow	swissprot:ACHA3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ACHA3_HUMAN
sigcleave	swissprot:ACHA3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ACHA3_HUMAN
## Database	ID	URL or Descriptions
# AltName	VP26B_HUMAN	Vesicle protein sorting 26B
# BioGrid	125215	46
# ChiTaRS	VPS26B	human
# Ensembl	ENST00000281187	ENSP00000281187; ENSG00000151502
# Ensembl	ENST00000525095	ENSP00000434162; ENSG00000151502
# ExpressionAtlas	Q4G0F5	baseline and differential
# FUNCTION	VP26B_HUMAN	Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (By similarity). {ECO 0000250|UniProtKB O75436, ECO 0000250|UniProtKB Q8C0E2}. 
# GO_component	GO:0005768	endosome; IBA:GO_Central.
# GO_component	GO:0005769	early endosome; ISS:UniProtKB.
# GO_component	GO:0005770	late endosome; ISS:UniProtKB.
# GO_component	GO:0005829	cytosol; ISS:UniProtKB.
# GO_component	GO:0030904	retromer complex; ISS:UniProtKB.
# GO_component	GO:0030906	retromer, cargo-selective complex; NAS:ParkinsonsUK-UCL.
# GO_function	GO:0008565	protein transporter activity; IBA:GO_Central.
# GO_process	GO:0006886	intracellular protein transport; IBA:GO_Central.
# GO_process	GO:0016241	regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
# GO_process	GO:0042147	retrograde transport, endosome to Golgi; ISS:UniProtKB.
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# Genevisible	Q4G0F5	HS
# HGNC	HGNC:28119	VPS26B
# IntAct	Q4G0F5	29
# InterPro	IPR028934	Vps26-related
# MIM	610027	gene
# Organism	VP26B_HUMAN	Homo sapiens (Human)
# Pfam	PF03643	Vps26
# Proteomes	UP000005640	Chromosome 11
# RecName	VP26B_HUMAN	Vacuolar protein sorting-associated protein 26B
# RefSeq	NP_443107	NM_052875.4
# SIMILARITY	Belongs to the VPS26 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	VP26B_HUMAN	Cytoplasm {ECO 0000250|UniProtKB Q8C0E2}. Membrane; Peripheral membrane protein {ECO 0000250|UniProtKB Q8C0E2}. Early endosome {ECO 0000250|UniProtKB Q8C0E2}. Late endosome {ECO 0000250|UniProtKB Q8C0E2}. Note=Localizes to early and late endosomal structures (By similarity). {ECO 0000250|UniProtKB Q8C0E2}. 
# SUBUNIT	VP26B_HUMAN	Component of the heterotrimeric retromer cargo-selective complex (CSC), also described as vacuolar protein sorting VPS subcomplex (VPS,) formed by VPS26 (VPS26A or VPS26B), VPS29 and VPS35. The CSC has a highly elongated structure with VPS26 and VPS29 binding independently at opposite distal ends of VPS35 as central platform. The CSC is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants. The originally described retromer complex (also called SNX-BAR retromer) is a pentamer containing the CSC and a heterodimeric membrane-deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the respective CSC and SNX-BAR subcomplexes associate with low affinity. The CSC associates with SNX3 to form a SNX3-retromer complex. The CSC associates with SNX27, the WASH complex and the SNX-BAR subcomplex to form the SNX27-retromer complex. Interacts with VPS29, VPS35, TBC1D5, GOLPH3, SNX27 (By similarity). {ECO 0000250|UniProtKB O75436, ECO 0000250|UniProtKB Q8C0E2}. 
# UCSC	uc001qhe	human
# eggNOG	ENOG410XSI1	LUCA
# eggNOG	KOG3063	Eukaryota
BLAST	swissprot:VP26B_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VP26B_HUMAN
COXPRESdb	112936	http://coxpresdb.jp/data/gene/112936.shtml
CleanEx	HS_VPS26B	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_VPS26B
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF452718	http://www.ebi.ac.uk/ena/data/view/AF452718
EMBL	BC009747	http://www.ebi.ac.uk/ena/data/view/BC009747
EMBL	BC014128	http://www.ebi.ac.uk/ena/data/view/BC014128
EMBL	BC098386	http://www.ebi.ac.uk/ena/data/view/BC098386
Ensembl	ENST00000281187	http://www.ensembl.org/id/ENST00000281187
Ensembl	ENST00000525095	http://www.ensembl.org/id/ENST00000525095
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GO_component	GO:0005769	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005769
GO_component	GO:0005770	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005770
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0030904	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030904
GO_component	GO:0030906	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030906
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0006886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006886
GO_process	GO:0016241	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016241
GO_process	GO:0042147	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042147
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GeneCards	VPS26B	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=VPS26B
GeneID	112936	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=112936
GeneTree	ENSGT00390000002588	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002588
HGNC	HGNC:28119	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:28119
HOGENOM	HOG000191799	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000191799&db=HOGENOM6
HOVERGEN	HBG082914	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG082914&db=HOVERGEN
HPA	HPA038172	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA038172
InParanoid	Q4G0F5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q4G0F5
IntAct	Q4G0F5	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q4G0F5*
InterPro	IPR028934	http://www.ebi.ac.uk/interpro/entry/IPR028934
Jabion	112936	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=112936
KEGG_Gene	hsa:112936	http://www.genome.jp/dbget-bin/www_bget?hsa:112936
MIM	610027	http://www.ncbi.nlm.nih.gov/omim/610027
OMA	GKRLEHH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GKRLEHH
OrthoDB	EOG091G09TQ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G09TQ
PSORT	swissprot:VP26B_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VP26B_HUMAN
PSORT-B	swissprot:VP26B_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VP26B_HUMAN
PSORT2	swissprot:VP26B_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VP26B_HUMAN
Pfam	PF03643	http://pfam.xfam.org/family/PF03643
PharmGKB	PA128394747	http://www.pharmgkb.org/do/serve?objId=PA128394747&objCls=Gene
Phobius	swissprot:VP26B_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VP26B_HUMAN
PhylomeDB	Q4G0F5	http://phylomedb.org/?seqid=Q4G0F5
ProteinModelPortal	Q4G0F5	http://www.proteinmodelportal.org/query/uniprot/Q4G0F5
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
RefSeq	NP_443107	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_443107
SMR	Q4G0F5	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q4G0F5
STRING	9606.ENSP00000281187	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000281187&targetmode=cogs
UCSC	uc001qhe	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001qhe&org=rat
UniGene	Hs.334684	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.334684
UniProtKB	VP26B_HUMAN	http://www.uniprot.org/uniprot/VP26B_HUMAN
UniProtKB-AC	Q4G0F5	http://www.uniprot.org/uniprot/Q4G0F5
charge	swissprot:VP26B_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VP26B_HUMAN
eggNOG	ENOG410XSI1	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSI1
eggNOG	KOG3063	http://eggnogapi.embl.de/nog_data/html/tree/KOG3063
epestfind	swissprot:VP26B_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VP26B_HUMAN
garnier	swissprot:VP26B_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VP26B_HUMAN
helixturnhelix	swissprot:VP26B_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VP26B_HUMAN
hmoment	swissprot:VP26B_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VP26B_HUMAN
iep	swissprot:VP26B_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VP26B_HUMAN
inforesidue	swissprot:VP26B_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VP26B_HUMAN
neXtProt	NX_Q4G0F5	http://www.nextprot.org/db/entry/NX_Q4G0F5
octanol	swissprot:VP26B_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VP26B_HUMAN
pepcoil	swissprot:VP26B_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VP26B_HUMAN
pepdigest	swissprot:VP26B_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VP26B_HUMAN
pepinfo	swissprot:VP26B_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VP26B_HUMAN
pepnet	swissprot:VP26B_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VP26B_HUMAN
pepstats	swissprot:VP26B_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VP26B_HUMAN
pepwheel	swissprot:VP26B_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VP26B_HUMAN
pepwindow	swissprot:VP26B_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VP26B_HUMAN
sigcleave	swissprot:VP26B_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VP26B_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S22A6_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=OAT1-1; IsoId=Q4U2R8-1; Sequence=Displayed; Name=2; Synonyms=OAT1-2; IsoId=Q4U2R8-2; Sequence=VSP_032169; Name=3; Synonyms=OAT1-3; IsoId=Q4U2R8-3; Sequence=VSP_032168, VSP_032169; Note=No experimental confirmation available.; Name=4; Synonyms=OAT1-4; IsoId=Q4U2R8-4; Sequence=VSP_032168; Note=No experimental confirmation available.; 
# AltName	S22A6_HUMAN	Organic anion transporter 1
# AltName	S22A6_HUMAN	PAH transporter
# AltName	S22A6_HUMAN	Renal organic anion transporter 1
# BIOPHYSICOCHEMICAL PROPERTIES	S22A6_HUMAN	Kinetic parameters  KM=9.3 uM for PAH (isoform 1) {ECO 0000269|PubMed 10462545, ECO 0000269|PubMed 10964714, ECO 0000269|PubMed 12538807, ECO 0000269|PubMed 15846473}; KM=4 uM for PAH (isoform 2) {ECO 0000269|PubMed 10462545, ECO 0000269|PubMed 10964714, ECO 0000269|PubMed 12538807, ECO 0000269|PubMed 15846473}; KM=11 uM for edaravone {ECO 0000269|PubMed 10462545, ECO 0000269|PubMed 10964714, ECO 0000269|PubMed 12538807, ECO 0000269|PubMed 15846473}; KM=46 uM for cidofovir {ECO 0000269|PubMed 10462545, ECO 0000269|PubMed 10964714, ECO 0000269|PubMed 12538807, ECO 0000269|PubMed 15846473}; KM=30 uM for adefovir {ECO 0000269|PubMed 10462545, ECO 0000269|PubMed 10964714, ECO 0000269|PubMed 12538807, ECO 0000269|PubMed 15846473}; KM=5.77 uM for 2,4-D {ECO 0000269|PubMed 10462545, ECO 0000269|PubMed 10964714, ECO 0000269|PubMed 12538807, ECO 0000269|PubMed 15846473}; KM=23.5 uM for HA {ECO 0000269|PubMed 10462545, ECO 0000269|PubMed 10964714, ECO 0000269|PubMed 12538807, ECO 0000269|PubMed 15846473}; KM=14 uM for IA {ECO 0000269|PubMed 10462545, ECO 0000269|PubMed 10964714, ECO 0000269|PubMed 12538807, ECO 0000269|PubMed 15846473}; KM=20.5 uM for IS {ECO 0000269|PubMed 10462545, ECO 0000269|PubMed 10964714, ECO 0000269|PubMed 12538807, ECO 0000269|PubMed 15846473}; KM=141 uM for CMPF {ECO 0000269|PubMed 10462545, ECO 0000269|PubMed 10964714, ECO 0000269|PubMed 12538807, ECO 0000269|PubMed 15846473}; Vmax=534 pmol/min/mg enzyme for 2,4-D uptake {ECO 0000269|PubMed 10462545, ECO 0000269|PubMed 10964714, ECO 0000269|PubMed 12538807, ECO 0000269|PubMed 15846473}; Vmax=430 pmol/min/mg enzyme for HA uptake {ECO 0000269|PubMed 10462545, ECO 0000269|PubMed 10964714, ECO 0000269|PubMed 12538807, ECO 0000269|PubMed 15846473}; Vmax=110 pmol/min/mg enzyme for IA uptake {ECO 0000269|PubMed 10462545, ECO 0000269|PubMed 10964714, ECO 0000269|PubMed 12538807, ECO 0000269|PubMed 15846473}; Vmax=216 pmol/min/mg enzyme for IS uptake {ECO 0000269|PubMed 10462545, ECO 0000269|PubMed 10964714, ECO 0000269|PubMed 12538807, ECO 0000269|PubMed 15846473}; Vmax=801 pmol/min/mg enzyme for CMPF uptake {ECO 0000269|PubMed 10462545, ECO 0000269|PubMed 10964714, ECO 0000269|PubMed 12538807, ECO 0000269|PubMed 15846473}; 
# BioGrid	114759	20
# CCDS	CCDS31591	-. [Q4U2R8-1]
# CCDS	CCDS44631	-. [Q4U2R8-4]
# CCDS	CCDS44632	-. [Q4U2R8-3]
# CCDS	CCDS8041	-. [Q4U2R8-2]
# CDD	cd06174	MFS
# DOMAIN	S22A6_HUMAN	Multiple cysteine residues are necessary for proper targeting to the plasma membrane. {ECO 0000250}. 
# DrugBank	DB00091	Cyclosporine
# DrugBank	DB00140	Riboflavin
# DrugBank	DB00158	Folic Acid
# DrugBank	DB00168	Aspartame
# DrugBank	DB00175	Pravastatin
# DrugBank	DB00229	Cefotiam
# DrugBank	DB00254	Doxycycline
# DrugBank	DB00286	Conjugated Estrogens
# DrugBank	DB00300	Tenofovir
# DrugBank	DB00313	Valproic Acid
# DrugBank	DB00316	Acetaminophen
# DrugBank	DB00319	Piperacillin
# DrugBank	DB00328	Indomethacin
# DrugBank	DB00345	Aminohippurate
# DrugBank	DB00369	Cidofovir
# DrugBank	DB00432	Trifluridine
# DrugBank	DB00438	Ceftazidime
# DrugBank	DB00446	Chloramphenicol
# DrugBank	DB00456	Cefalotin
# DrugBank	DB00493	Cefotaxime
# DrugBank	DB00495	Zidovudine
# DrugBank	DB00500	Tolmetin
# DrugBank	DB00501	Cimetidine
# DrugBank	DB00512	Vancomycin
# DrugBank	DB00520	Caspofungin
# DrugBank	DB00529	Foscarnet
# DrugBank	DB00554	Piroxicam
# DrugBank	DB00563	Methotrexate
# DrugBank	DB00567	Cephalexin
# DrugBank	DB00577	Valaciclovir
# DrugBank	DB00578	Carbenicillin
# DrugBank	DB00584	Enalapril
# DrugBank	DB00586	Diclofenac
# DrugBank	DB00595	Oxytetracycline
# DrugBank	DB00605	Sulindac
# DrugBank	DB00606	Cyclothiazide
# DrugBank	DB00607	Nafcillin
# DrugBank	DB00649	Stavudine
# DrugBank	DB00672	Chlorpropamide
# DrugBank	DB00678	Losartan
# DrugBank	DB00693	Fluorescein
# DrugBank	DB00695	Furosemide
# DrugBank	DB00703	Methazolamide
# DrugBank	DB00709	Lamivudine
# DrugBank	DB00712	Flurbiprofen
# DrugBank	DB00718	Adefovir Dipivoxil
# DrugBank	DB00731	Nateglinide
# DrugBank	DB00749	Etodolac
# DrugBank	DB00759	Tetracycline
# DrugBank	DB00779	Nalidixic Acid
# DrugBank	DB00787	Aciclovir
# DrugBank	DB00788	Naproxen
# DrugBank	DB00798	Gentamicin
# DrugBank	DB00812	Phenylbutazone
# DrugBank	DB00819	Acetazolamide
# DrugBank	DB00821	Carprofen
# DrugBank	DB00827	Cinoxacin
# DrugBank	DB00861	Diflunisal
# DrugBank	DB00880	Chlorothiazide
# DrugBank	DB00887	Bumetanide
# DrugBank	DB00900	Didanosine
# DrugBank	DB00903	Ethacrynic acid
# DrugBank	DB00917	Dinoprostone
# DrugBank	DB00936	Salicylic acid
# DrugBank	DB00939	Meclofenamic acid
# DrugBank	DB00943	Zalcitabine
# DrugBank	DB00945	Acetylsalicylic acid
# DrugBank	DB00999	Hydrochlorothiazide
# DrugBank	DB01004	Ganciclovir
# DrugBank	DB01009	Ketoprofen
# DrugBank	DB01016	Glyburide
# DrugBank	DB01017	Minocycline
# DrugBank	DB01032	Probenecid
# DrugBank	DB01050	Ibuprofen
# DrugBank	DB01051	Novobiocin
# DrugBank	DB01053	Benzylpenicillin
# DrugBank	DB01059	Norfloxacin
# DrugBank	DB01060	Amoxicillin
# DrugBank	DB01082	Streptomycin
# DrugBank	DB01124	Tolbutamide
# DrugBank	DB01137	Levofloxacin
# DrugBank	DB01140	Cefadroxil
# DrugBank	DB01147	Cloxacillin
# DrugBank	DB01160	Dinoprost Tromethamine
# DrugBank	DB01165	Ofloxacin
# DrugBank	DB01197	Captopril
# DrugBank	DB01212	Ceftriaxone
# DrugBank	DB01237	Bromodiphenhydramine
# DrugBank	DB01326	Cefamandole
# DrugBank	DB01327	Cefazolin
# DrugBank	DB01329	Cefoperazone
# DrugBank	DB01333	Cefradine
# DrugBank	DB01414	Cefacetrile
# DrugBank	DB01424	Aminophenazone
# DrugBank	DB01435	Antipyrine
# DrugBank	DB01597	Cilastatin
# DrugBank	DB06151	Acetylcysteine
# DrugBank	DB08912	Dabrafenib
# Ensembl	ENST00000360421	ENSP00000353597; ENSG00000197901. [Q4U2R8-2]
# Ensembl	ENST00000377871	ENSP00000367102; ENSG00000197901. [Q4U2R8-1]
# Ensembl	ENST00000421062	ENSP00000404441; ENSG00000197901. [Q4U2R8-4]
# Ensembl	ENST00000458333	ENSP00000396401; ENSG00000197901. [Q4U2R8-3]
# ExpressionAtlas	Q4U2R8	baseline and differential
# FUNCTION	S22A6_HUMAN	Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-independent uptake of p- aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido- 3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro- phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2- furanpropionate (CMPF), cidofovir, adefovir, 9-(2- phosphonylmethoxyethyl) guanine (PMEG), 9-(2- phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p- chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid (By similarity). PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate. {ECO 0000250, ECO 0000269|PubMed 12538807, ECO 0000269|PubMed 15644426, ECO 0000269|PubMed 17038320, ECO 0000269|PubMed 17502342, ECO 0000269|PubMed 9762842, ECO 0000269|PubMed 9887087}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005901	caveola; IEA:Ensembl.
# GO_component	GO:0016323	basolateral plasma membrane; IDA:UniProtKB.
# GO_component	GO:0043234	protein complex; IEA:Ensembl.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005452	inorganic anion exchanger activity; IDA:UniProtKB.
# GO_function	GO:0008514	organic anion transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015347	sodium-independent organic anion transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0031404	chloride ion binding; IEA:Ensembl.
# GO_function	S22A6_HUMAN	GO 0015301 anion anion antiporter activity; TAS Reactome.
# GO_process	GO:0015711	organic anion transport; IDA:UniProtKB.
# GO_process	GO:0015742	alpha-ketoglutarate transport; IDA:UniProtKB.
# GO_process	GO:0031427	response to methotrexate; IEA:Ensembl.
# GO_process	GO:0043252	sodium-independent organic anion transport; IDA:UniProtKB.
# GO_process	GO:0051260	protein homooligomerization; IEA:Ensembl.
# GO_process	GO:0097254	renal tubular secretion; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q4U2R8	HS
# HGNC	HGNC:10970	SLC22A6
# INTERACTION	S22A6_HUMAN	Q92624 APPBP2; NbExp=3; IntAct=EBI-749741, EBI-743771; 
# InterPro	IPR004749	Orgcat_transp/SVOP
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	607582	gene
# Organism	S22A6_HUMAN	Homo sapiens (Human)
# PROSITE	PS50850	MFS
# PTM	S22A6_HUMAN	Glycosylated. Glycosylation at Asn-113 may occur at a secondary level. Glycosylation is necessary for proper targeting of the transporter to the plasma membrane. {ECO 0000269|PubMed 10462545, ECO 0000269|PubMed 14749323}. 
# Pfam	PF00083	Sugar_tr
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-561048	Organic anion transport
# RecName	S22A6_HUMAN	Solute carrier family 22 member 6
# RefSeq	NP_004781	NM_004790.4. [Q4U2R8-1]
# RefSeq	NP_695008	NM_153276.2. [Q4U2R8-2]
# RefSeq	NP_695009	NM_153277.2. [Q4U2R8-3]
# RefSeq	NP_695010	NM_153278.2. [Q4U2R8-4]
# SIMILARITY	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S22A6_HUMAN	Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.19.31	the major facilitator superfamily (mfs)
# TIGRFAMs	TIGR00898	2A0119
# TISSUE SPECIFICITY	S22A6_HUMAN	Strongly expressed in kidney and to a lower extent in liver, skeletal muscle, brain and placenta. Found at the basolateral membrane of the proximal tubule. {ECO 0000269|PubMed 10049739, ECO 0000269|PubMed 10462545, ECO 0000269|PubMed 10964714, ECO 0000269|PubMed 9887087, ECO 0000269|PubMed 9950961}. 
# UCSC	uc001nwj	human. [Q4U2R8-1]
# WEB RESOURCE	S22A6_HUMAN	Name=NIEHS-SNPs; URL="http //egp.gs.washington.edu/data/slc22a6/";
# eggNOG	COG0477	LUCA
# eggNOG	KOG0255	Eukaryota
BLAST	swissprot:S22A6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S22A6_HUMAN
BioCyc	ZFISH:G66-32260-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32260-MONOMER
COXPRESdb	9356	http://coxpresdb.jp/data/gene/9356.shtml
DOI	10.1006/bbrc.1998.9978	http://dx.doi.org/10.1006/bbrc.1998.9978
DOI	10.1006/bbrc.2000.3230	http://dx.doi.org/10.1006/bbrc.2000.3230
DOI	10.1007/s11095-005-2503-0	http://dx.doi.org/10.1007/s11095-005-2503-0
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1074/jbc.M400197200	http://dx.doi.org/10.1074/jbc.M400197200
DOI	10.1074/jbc.M404686200	http://dx.doi.org/10.1074/jbc.M404686200
DOI	10.1074/jbc.M608834200	http://dx.doi.org/10.1074/jbc.M608834200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1523-1755.2005.00612.x	http://dx.doi.org/10.1111/j.1523-1755.2005.00612.x
DOI	10.1124/dmd.106.013912	http://dx.doi.org/10.1124/dmd.106.013912
DOI	10.1124/jpet.102.043455	http://dx.doi.org/10.1124/jpet.102.043455
DOI	10.1124/jpet.104.080366	http://dx.doi.org/10.1124/jpet.104.080366
DOI	10.1124/jpet.105.084301	http://dx.doi.org/10.1124/jpet.105.084301
DOI	10.1159/000025863	http://dx.doi.org/10.1159/000025863
DrugBank	DB00091	http://www.drugbank.ca/drugs/DB00091
DrugBank	DB00140	http://www.drugbank.ca/drugs/DB00140
DrugBank	DB00158	http://www.drugbank.ca/drugs/DB00158
DrugBank	DB00168	http://www.drugbank.ca/drugs/DB00168
DrugBank	DB00175	http://www.drugbank.ca/drugs/DB00175
DrugBank	DB00229	http://www.drugbank.ca/drugs/DB00229
DrugBank	DB00254	http://www.drugbank.ca/drugs/DB00254
DrugBank	DB00286	http://www.drugbank.ca/drugs/DB00286
DrugBank	DB00300	http://www.drugbank.ca/drugs/DB00300
DrugBank	DB00313	http://www.drugbank.ca/drugs/DB00313
DrugBank	DB00316	http://www.drugbank.ca/drugs/DB00316
DrugBank	DB00319	http://www.drugbank.ca/drugs/DB00319
DrugBank	DB00328	http://www.drugbank.ca/drugs/DB00328
DrugBank	DB00345	http://www.drugbank.ca/drugs/DB00345
DrugBank	DB00369	http://www.drugbank.ca/drugs/DB00369
DrugBank	DB00432	http://www.drugbank.ca/drugs/DB00432
DrugBank	DB00438	http://www.drugbank.ca/drugs/DB00438
DrugBank	DB00446	http://www.drugbank.ca/drugs/DB00446
DrugBank	DB00456	http://www.drugbank.ca/drugs/DB00456
DrugBank	DB00493	http://www.drugbank.ca/drugs/DB00493
DrugBank	DB00495	http://www.drugbank.ca/drugs/DB00495
DrugBank	DB00500	http://www.drugbank.ca/drugs/DB00500
DrugBank	DB00501	http://www.drugbank.ca/drugs/DB00501
DrugBank	DB00512	http://www.drugbank.ca/drugs/DB00512
DrugBank	DB00520	http://www.drugbank.ca/drugs/DB00520
DrugBank	DB00529	http://www.drugbank.ca/drugs/DB00529
DrugBank	DB00554	http://www.drugbank.ca/drugs/DB00554
DrugBank	DB00563	http://www.drugbank.ca/drugs/DB00563
DrugBank	DB00567	http://www.drugbank.ca/drugs/DB00567
DrugBank	DB00577	http://www.drugbank.ca/drugs/DB00577
DrugBank	DB00578	http://www.drugbank.ca/drugs/DB00578
DrugBank	DB00584	http://www.drugbank.ca/drugs/DB00584
DrugBank	DB00586	http://www.drugbank.ca/drugs/DB00586
DrugBank	DB00595	http://www.drugbank.ca/drugs/DB00595
DrugBank	DB00605	http://www.drugbank.ca/drugs/DB00605
DrugBank	DB00606	http://www.drugbank.ca/drugs/DB00606
DrugBank	DB00607	http://www.drugbank.ca/drugs/DB00607
DrugBank	DB00649	http://www.drugbank.ca/drugs/DB00649
DrugBank	DB00672	http://www.drugbank.ca/drugs/DB00672
DrugBank	DB00678	http://www.drugbank.ca/drugs/DB00678
DrugBank	DB00693	http://www.drugbank.ca/drugs/DB00693
DrugBank	DB00695	http://www.drugbank.ca/drugs/DB00695
DrugBank	DB00703	http://www.drugbank.ca/drugs/DB00703
DrugBank	DB00709	http://www.drugbank.ca/drugs/DB00709
DrugBank	DB00712	http://www.drugbank.ca/drugs/DB00712
DrugBank	DB00718	http://www.drugbank.ca/drugs/DB00718
DrugBank	DB00731	http://www.drugbank.ca/drugs/DB00731
DrugBank	DB00749	http://www.drugbank.ca/drugs/DB00749
DrugBank	DB00759	http://www.drugbank.ca/drugs/DB00759
DrugBank	DB00779	http://www.drugbank.ca/drugs/DB00779
DrugBank	DB00787	http://www.drugbank.ca/drugs/DB00787
DrugBank	DB00788	http://www.drugbank.ca/drugs/DB00788
DrugBank	DB00798	http://www.drugbank.ca/drugs/DB00798
DrugBank	DB00812	http://www.drugbank.ca/drugs/DB00812
DrugBank	DB00819	http://www.drugbank.ca/drugs/DB00819
DrugBank	DB00821	http://www.drugbank.ca/drugs/DB00821
DrugBank	DB00827	http://www.drugbank.ca/drugs/DB00827
DrugBank	DB00861	http://www.drugbank.ca/drugs/DB00861
DrugBank	DB00880	http://www.drugbank.ca/drugs/DB00880
DrugBank	DB00887	http://www.drugbank.ca/drugs/DB00887
DrugBank	DB00900	http://www.drugbank.ca/drugs/DB00900
DrugBank	DB00903	http://www.drugbank.ca/drugs/DB00903
DrugBank	DB00917	http://www.drugbank.ca/drugs/DB00917
DrugBank	DB00936	http://www.drugbank.ca/drugs/DB00936
DrugBank	DB00939	http://www.drugbank.ca/drugs/DB00939
DrugBank	DB00943	http://www.drugbank.ca/drugs/DB00943
DrugBank	DB00945	http://www.drugbank.ca/drugs/DB00945
DrugBank	DB00999	http://www.drugbank.ca/drugs/DB00999
DrugBank	DB01004	http://www.drugbank.ca/drugs/DB01004
DrugBank	DB01009	http://www.drugbank.ca/drugs/DB01009
DrugBank	DB01016	http://www.drugbank.ca/drugs/DB01016
DrugBank	DB01017	http://www.drugbank.ca/drugs/DB01017
DrugBank	DB01032	http://www.drugbank.ca/drugs/DB01032
DrugBank	DB01050	http://www.drugbank.ca/drugs/DB01050
DrugBank	DB01051	http://www.drugbank.ca/drugs/DB01051
DrugBank	DB01053	http://www.drugbank.ca/drugs/DB01053
DrugBank	DB01059	http://www.drugbank.ca/drugs/DB01059
DrugBank	DB01060	http://www.drugbank.ca/drugs/DB01060
DrugBank	DB01082	http://www.drugbank.ca/drugs/DB01082
DrugBank	DB01124	http://www.drugbank.ca/drugs/DB01124
DrugBank	DB01137	http://www.drugbank.ca/drugs/DB01137
DrugBank	DB01140	http://www.drugbank.ca/drugs/DB01140
DrugBank	DB01147	http://www.drugbank.ca/drugs/DB01147
DrugBank	DB01160	http://www.drugbank.ca/drugs/DB01160
DrugBank	DB01165	http://www.drugbank.ca/drugs/DB01165
DrugBank	DB01197	http://www.drugbank.ca/drugs/DB01197
DrugBank	DB01212	http://www.drugbank.ca/drugs/DB01212
DrugBank	DB01237	http://www.drugbank.ca/drugs/DB01237
DrugBank	DB01326	http://www.drugbank.ca/drugs/DB01326
DrugBank	DB01327	http://www.drugbank.ca/drugs/DB01327
DrugBank	DB01329	http://www.drugbank.ca/drugs/DB01329
DrugBank	DB01333	http://www.drugbank.ca/drugs/DB01333
DrugBank	DB01414	http://www.drugbank.ca/drugs/DB01414
DrugBank	DB01424	http://www.drugbank.ca/drugs/DB01424
DrugBank	DB01435	http://www.drugbank.ca/drugs/DB01435
DrugBank	DB01597	http://www.drugbank.ca/drugs/DB01597
DrugBank	DB06151	http://www.drugbank.ca/drugs/DB06151
DrugBank	DB08912	http://www.drugbank.ca/drugs/DB08912
EMBL	AB009697	http://www.ebi.ac.uk/ena/data/view/AB009697
EMBL	AB009698	http://www.ebi.ac.uk/ena/data/view/AB009698
EMBL	AF057039	http://www.ebi.ac.uk/ena/data/view/AF057039
EMBL	AF097490	http://www.ebi.ac.uk/ena/data/view/AF097490
EMBL	AF104038	http://www.ebi.ac.uk/ena/data/view/AF104038
EMBL	AF124373	http://www.ebi.ac.uk/ena/data/view/AF124373
EMBL	AJ249369	http://www.ebi.ac.uk/ena/data/view/AJ249369
EMBL	AJ251529	http://www.ebi.ac.uk/ena/data/view/AJ251529
EMBL	AJ271205	http://www.ebi.ac.uk/ena/data/view/AJ271205
EMBL	AP001858	http://www.ebi.ac.uk/ena/data/view/AP001858
EMBL	BC033682	http://www.ebi.ac.uk/ena/data/view/BC033682
EMBL	CH471076	http://www.ebi.ac.uk/ena/data/view/CH471076
EMBL	CH471076	http://www.ebi.ac.uk/ena/data/view/CH471076
EMBL	CH471076	http://www.ebi.ac.uk/ena/data/view/CH471076
EMBL	CH471076	http://www.ebi.ac.uk/ena/data/view/CH471076
EMBL	EU567146	http://www.ebi.ac.uk/ena/data/view/EU567146
Ensembl	ENST00000360421	http://www.ensembl.org/id/ENST00000360421
Ensembl	ENST00000377871	http://www.ensembl.org/id/ENST00000377871
Ensembl	ENST00000421062	http://www.ensembl.org/id/ENST00000421062
Ensembl	ENST00000458333	http://www.ensembl.org/id/ENST00000458333
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005901
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005452	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005452
GO_function	GO:0008514	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008514
GO_function	GO:0015301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015301
GO_function	GO:0015347	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015347
GO_function	GO:0031404	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031404
GO_process	GO:0015711	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015711
GO_process	GO:0015742	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015742
GO_process	GO:0031427	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031427
GO_process	GO:0043252	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043252
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:0097254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097254
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	SLC22A6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC22A6
GeneID	9356	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9356
GeneTree	ENSGT00760000118852	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118852
HGNC	HGNC:10970	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10970
HOVERGEN	HBG108433	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108433&db=HOVERGEN
InParanoid	Q4U2R8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q4U2R8
IntAct	Q4U2R8	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q4U2R8*
InterPro	IPR004749	http://www.ebi.ac.uk/interpro/entry/IPR004749
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	9356	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9356
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:9356	http://www.genome.jp/dbget-bin/www_bget?hsa:9356
KEGG_Orthology	KO:K08203	http://www.genome.jp/dbget-bin/www_bget?KO:K08203
MIM	607582	http://www.ncbi.nlm.nih.gov/omim/607582
MINT	MINT-1474237	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1474237
OMA	MIRQTGM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MIRQTGM
OrthoDB	EOG091G07CO	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07CO
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:S22A6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S22A6_HUMAN
PSORT-B	swissprot:S22A6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S22A6_HUMAN
PSORT2	swissprot:S22A6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S22A6_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
PharmGKB	PA388	http://www.pharmgkb.org/do/serve?objId=PA388&objCls=Gene
Phobius	swissprot:S22A6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S22A6_HUMAN
PhylomeDB	Q4U2R8	http://phylomedb.org/?seqid=Q4U2R8
ProteinModelPortal	Q4U2R8	http://www.proteinmodelportal.org/query/uniprot/Q4U2R8
PubMed	10049739	http://www.ncbi.nlm.nih.gov/pubmed/10049739
PubMed	10462545	http://www.ncbi.nlm.nih.gov/pubmed/10462545
PubMed	10964714	http://www.ncbi.nlm.nih.gov/pubmed/10964714
PubMed	12538807	http://www.ncbi.nlm.nih.gov/pubmed/12538807
PubMed	14749323	http://www.ncbi.nlm.nih.gov/pubmed/14749323
PubMed	15145940	http://www.ncbi.nlm.nih.gov/pubmed/15145940
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15644426	http://www.ncbi.nlm.nih.gov/pubmed/15644426
PubMed	15846473	http://www.ncbi.nlm.nih.gov/pubmed/15846473
PubMed	15914676	http://www.ncbi.nlm.nih.gov/pubmed/15914676
PubMed	16164626	http://www.ncbi.nlm.nih.gov/pubmed/16164626
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	17038320	http://www.ncbi.nlm.nih.gov/pubmed/17038320
PubMed	17502342	http://www.ncbi.nlm.nih.gov/pubmed/17502342
PubMed	9762842	http://www.ncbi.nlm.nih.gov/pubmed/9762842
PubMed	9887087	http://www.ncbi.nlm.nih.gov/pubmed/9887087
PubMed	9950961	http://www.ncbi.nlm.nih.gov/pubmed/9950961
Reactome	R-HSA-561048	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-561048
RefSeq	NP_004781	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004781
RefSeq	NP_695008	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_695008
RefSeq	NP_695009	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_695009
RefSeq	NP_695010	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_695010
STRING	9606.ENSP00000367102	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000367102&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.19.31	http://www.tcdb.org/search/result.php?tc=2.A.1.19.31
TIGRFAMs	TIGR00898	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00898
UCSC	uc001nwj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001nwj&org=rat
UniGene	Hs.369252	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.369252
UniProtKB	S22A6_HUMAN	http://www.uniprot.org/uniprot/S22A6_HUMAN
UniProtKB-AC	Q4U2R8	http://www.uniprot.org/uniprot/Q4U2R8
charge	swissprot:S22A6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S22A6_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG0255	http://eggnogapi.embl.de/nog_data/html/tree/KOG0255
epestfind	swissprot:S22A6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S22A6_HUMAN
garnier	swissprot:S22A6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S22A6_HUMAN
helixturnhelix	swissprot:S22A6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S22A6_HUMAN
hmoment	swissprot:S22A6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S22A6_HUMAN
iep	swissprot:S22A6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S22A6_HUMAN
inforesidue	swissprot:S22A6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S22A6_HUMAN
neXtProt	NX_Q4U2R8	http://www.nextprot.org/db/entry/NX_Q4U2R8
octanol	swissprot:S22A6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S22A6_HUMAN
pepcoil	swissprot:S22A6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S22A6_HUMAN
pepdigest	swissprot:S22A6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S22A6_HUMAN
pepinfo	swissprot:S22A6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S22A6_HUMAN
pepnet	swissprot:S22A6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S22A6_HUMAN
pepstats	swissprot:S22A6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S22A6_HUMAN
pepwheel	swissprot:S22A6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S22A6_HUMAN
pepwindow	swissprot:S22A6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S22A6_HUMAN
sigcleave	swissprot:S22A6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S22A6_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	FXYD3_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q14802-1; Sequence=Displayed; Name=2; IsoId=Q14802-2; Sequence=VSP_034598; Name=3; IsoId=Q14802-3; Sequence=VSP_045716; Note=No experimental confirmation available.; Name=4; IsoId=Q14802-4; Sequence=VSP_034598, VSP_047287; Note=No experimental confirmation available. Gene prediction based on EST data.; Name=5; IsoId=Q14802-5; Sequence=VSP_047286; Note=No experimental confirmation available. Gene prediction based on EST data.; 
# AltName	FXYD3_HUMAN	Chloride conductance inducer protein Mat-8
# AltName	FXYD3_HUMAN	Mammary tumor 8 kDa protein
# AltName	FXYD3_HUMAN	Phospholemman-like
# BioGrid	111364	7
# CCDS	CCDS12442	-. [Q14802-1]
# CCDS	CCDS12443	-. [Q14802-2]
# CCDS	CCDS46048	-. [Q14802-3]
# CCDS	CCDS46049	-. [Q14802-4]
# CCDS	CCDS46050	-. [Q14802-5]
# ChiTaRS	FXYD3	human
# Ensembl	ENST00000344013	ENSP00000339499; ENSG00000089356. [Q14802-2]
# Ensembl	ENST00000346446	ENSP00000328259; ENSG00000089356. [Q14802-2]
# Ensembl	ENST00000435734	ENSP00000389770; ENSG00000089356. [Q14802-2]
# Ensembl	ENST00000603181	ENSP00000474851; ENSG00000089356. [Q14802-1]
# Ensembl	ENST00000603449	ENSP00000474055; ENSG00000089356. [Q14802-5]
# Ensembl	ENST00000604255	ENSP00000473929; ENSG00000089356. [Q14802-3]
# Ensembl	ENST00000604404	ENSP00000474438; ENSG00000089356. [Q14802-1]
# Ensembl	ENST00000604621	ENSP00000474526; ENSG00000089356. [Q14802-1]
# Ensembl	ENST00000605552	ENSP00000474855; ENSG00000089356. [Q14802-5]
# Ensembl	ENST00000605677	ENSP00000474622; ENSG00000089356. [Q14802-4]
# ExpressionAtlas	Q14802	baseline and differential
# FUNCTION	FXYD3_HUMAN	Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. May be a modulator capable of activating endogenous oocyte channels. 
# GO_component	GO:0005789	endoplasmic reticulum membrane; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005254	chloride channel activity; TAS:ProtInc.
# GO_function	GO:0017080	sodium channel regulator activity; IBA:GO_Central.
# GO_process	GO:0006821	chloride transport; TAS:ProtInc.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0050790	regulation of catalytic activity; IEA:Ensembl.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GO_process	GO:2000649	regulation of sodium ion transmembrane transporter activity; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q14802	HS
# HGNC	HGNC:4027	FXYD3
# IntAct	Q14802	8
# InterPro	IPR000272	Ion-transport_regulator_FXYD
# KEGG_Brite	ko02000	Transporters
# MIM	604996	gene
# MISCELLANEOUS	FXYD3_HUMAN	Marker of a cell type preferentially transformed by neu or ras oncoprotein. 
# Organism	FXYD3_HUMAN	Homo sapiens (Human)
# PIR	A55571	A55571
# PROSITE	PS01310	FXYD
# Pfam	PF02038	ATP1G1_PLM_MAT8
# ProDom	PD005989	PD005989
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-5578775	Ion homeostasis
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	FXYD3_HUMAN	FXYD domain-containing ion transport regulator 3
# RefSeq	NP_001129479	NM_001136007.1. [Q14802-3]
# RefSeq	NP_001129480	NM_001136008.1. [Q14802-4]
# RefSeq	NP_001129481	NM_001136009.1. [Q14802-5]
# RefSeq	NP_001129482	NM_001136010.1. [Q14802-5]
# RefSeq	NP_001129483	NM_001136011.1. [Q14802-1]
# RefSeq	NP_001129484	NM_001136012.1. [Q14802-2]
# RefSeq	NP_005962	NM_005971.3. [Q14802-1]
# RefSeq	NP_068710	NM_021910.2. [Q14802-2]
# RefSeq	XP_005259053	XM_005258996.4. [Q14802-2]
# RefSeq	XP_016882366	XM_017026877.1. [Q14802-1]
# RefSeq	XP_016882367	XM_017026878.1. [Q14802-1]
# SIMILARITY	Belongs to the FXYD family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	FXYD3_HUMAN	Membrane {ECO 0000305}; Single-pass type I membrane protein {ECO 0000305}. 
# TISSUE SPECIFICITY	FXYD3_HUMAN	Expressed in a subset of human breast tumors. 
# UCSC	uc002nxv	human. [Q14802-1]
# WEB RESOURCE	FXYD3_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/FXYD3ID43704ch19q13.html";
# eggNOG	ENOG410J4PQ	Eukaryota
# eggNOG	ENOG4111AWX	LUCA
BLAST	swissprot:FXYD3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:FXYD3_HUMAN
BioCyc	ZFISH:ENSG00000089356-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000089356-MONOMER
COXPRESdb	5349	http://coxpresdb.jp/data/gene/5349.shtml
CleanEx	HS_FXYD3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_FXYD3
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DOI	10.1074/jbc.270.5.2176	http://dx.doi.org/10.1074/jbc.270.5.2176
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC020907	http://www.ebi.ac.uk/ena/data/view/AC020907
EMBL	BC005238	http://www.ebi.ac.uk/ena/data/view/BC005238
EMBL	BC090044	http://www.ebi.ac.uk/ena/data/view/BC090044
EMBL	BT006712	http://www.ebi.ac.uk/ena/data/view/BT006712
EMBL	BU157560	http://www.ebi.ac.uk/ena/data/view/BU157560
EMBL	CR456945	http://www.ebi.ac.uk/ena/data/view/CR456945
EMBL	CR542197	http://www.ebi.ac.uk/ena/data/view/CR542197
EMBL	U28249	http://www.ebi.ac.uk/ena/data/view/U28249
EMBL	X93036	http://www.ebi.ac.uk/ena/data/view/X93036
Ensembl	ENST00000344013	http://www.ensembl.org/id/ENST00000344013
Ensembl	ENST00000346446	http://www.ensembl.org/id/ENST00000346446
Ensembl	ENST00000435734	http://www.ensembl.org/id/ENST00000435734
Ensembl	ENST00000603181	http://www.ensembl.org/id/ENST00000603181
Ensembl	ENST00000603449	http://www.ensembl.org/id/ENST00000603449
Ensembl	ENST00000604255	http://www.ensembl.org/id/ENST00000604255
Ensembl	ENST00000604404	http://www.ensembl.org/id/ENST00000604404
Ensembl	ENST00000604621	http://www.ensembl.org/id/ENST00000604621
Ensembl	ENST00000605552	http://www.ensembl.org/id/ENST00000605552
Ensembl	ENST00000605677	http://www.ensembl.org/id/ENST00000605677
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0017080	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017080
GO_process	GO:0006821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006821
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0050790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050790
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GO_process	GO:2000649	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000649
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	FXYD3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=FXYD3
GeneID	5349	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5349
GeneTree	ENSGT00530000063998	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063998
HGNC	HGNC:4027	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4027
HOGENOM	HOG000234469	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234469&db=HOGENOM6
HOVERGEN	HBG008212	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG008212&db=HOVERGEN
HPA	HPA010856	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA010856
InParanoid	Q14802	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q14802
IntAct	Q14802	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q14802*
InterPro	IPR000272	http://www.ebi.ac.uk/interpro/entry/IPR000272
Jabion	5349	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=5349
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:5349	http://www.genome.jp/dbget-bin/www_bget?hsa:5349
KEGG_Orthology	KO:K13361	http://www.genome.jp/dbget-bin/www_bget?KO:K13361
MIM	604996	http://www.ncbi.nlm.nih.gov/omim/604996
MINT	MINT-5004597	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5004597
OMA	KPSHRPG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KPSHRPG
OrthoDB	EOG091G14HJ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G14HJ
PROSITE	PS01310	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01310
PSORT	swissprot:FXYD3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:FXYD3_HUMAN
PSORT-B	swissprot:FXYD3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:FXYD3_HUMAN
PSORT2	swissprot:FXYD3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:FXYD3_HUMAN
Pfam	PF02038	http://pfam.xfam.org/family/PF02038
PharmGKB	PA28443	http://www.pharmgkb.org/do/serve?objId=PA28443&objCls=Gene
Phobius	swissprot:FXYD3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:FXYD3_HUMAN
PhylomeDB	Q14802	http://phylomedb.org/?seqid=Q14802
ProteinModelPortal	Q14802	http://www.proteinmodelportal.org/query/uniprot/Q14802
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	7836447	http://www.ncbi.nlm.nih.gov/pubmed/7836447
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_001129479	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001129479
RefSeq	NP_001129480	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001129480
RefSeq	NP_001129481	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001129481
RefSeq	NP_001129482	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001129482
RefSeq	NP_001129483	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001129483
RefSeq	NP_001129484	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001129484
RefSeq	NP_005962	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005962
RefSeq	NP_068710	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_068710
RefSeq	XP_005259053	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005259053
RefSeq	XP_016882366	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016882366
RefSeq	XP_016882367	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016882367
SMR	Q14802	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q14802
STRING	9606.ENSP00000389770	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000389770&targetmode=cogs
UCSC	uc002nxv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002nxv&org=rat
UniGene	Hs.301350	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.301350
UniProtKB	FXYD3_HUMAN	http://www.uniprot.org/uniprot/FXYD3_HUMAN
UniProtKB-AC	Q14802	http://www.uniprot.org/uniprot/Q14802
charge	swissprot:FXYD3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:FXYD3_HUMAN
eggNOG	ENOG410J4PQ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410J4PQ
eggNOG	ENOG4111AWX	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111AWX
epestfind	swissprot:FXYD3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:FXYD3_HUMAN
garnier	swissprot:FXYD3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:FXYD3_HUMAN
helixturnhelix	swissprot:FXYD3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:FXYD3_HUMAN
hmoment	swissprot:FXYD3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:FXYD3_HUMAN
iep	swissprot:FXYD3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:FXYD3_HUMAN
inforesidue	swissprot:FXYD3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:FXYD3_HUMAN
neXtProt	NX_Q14802	http://www.nextprot.org/db/entry/NX_Q14802
octanol	swissprot:FXYD3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:FXYD3_HUMAN
pepcoil	swissprot:FXYD3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:FXYD3_HUMAN
pepdigest	swissprot:FXYD3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:FXYD3_HUMAN
pepinfo	swissprot:FXYD3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:FXYD3_HUMAN
pepnet	swissprot:FXYD3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:FXYD3_HUMAN
pepstats	swissprot:FXYD3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:FXYD3_HUMAN
pepwheel	swissprot:FXYD3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:FXYD3_HUMAN
pepwindow	swissprot:FXYD3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:FXYD3_HUMAN
sigcleave	swissprot:FXYD3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:FXYD3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ATP5H_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75947-1; Sequence=Displayed; Name=2; IsoId=O75947-2; Sequence=VSP_000436; 
# BioGrid	115739	58
# CCDS	CCDS11712	-. [O75947-1]
# CCDS	CCDS32727	-. [O75947-2]
# Ensembl	ENST00000301587	ENSP00000301587; ENSG00000167863. [O75947-1]
# Ensembl	ENST00000344546	ENSP00000344230; ENSG00000167863. [O75947-2]
# ExpressionAtlas	O75947	baseline and differential
# FUNCTION	ATP5H_HUMAN	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. 
# GO_component	GO:0000274	mitochondrial proton-transporting ATP synthase, stator stalk; IBA:GO_Central.
# GO_component	GO:0005654	nucleoplasm; IDA:HPA.
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; IDA:UniProtKB.
# GO_component	GO:0005753	mitochondrial proton-transporting ATP synthase complex; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0015078	hydrogen ion transmembrane transporter activity; IEA:InterPro.
# GO_function	GO:0022857	transmembrane transporter activity; IC:UniProtKB.
# GO_process	GO:0006754	ATP biosynthetic process; TAS:Reactome.
# GO_process	GO:0015986	ATP synthesis coupled proton transport; IBA:GO_Central.
# GO_process	GO:0042776	mitochondrial ATP synthesis coupled proton transport; IC:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	O75947	HS
# HGNC	HGNC:845	ATP5H
# IntAct	O75947	28
# InterPro	IPR008689	ATP_synth_F0_dsu_mt
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# Organism	ATP5H_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12700	PTHR12700
# PIRSF	PIRSF005514	ATPase_F0_D_mt
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-163210	Formation of ATP by chemiosmotic coupling
# RecName	ATP5H_HUMAN	ATP synthase subunit d, mitochondrial
# RefSeq	NP_001003785	NM_001003785.1. [O75947-2]
# RefSeq	NP_006347	NM_006356.2. [O75947-1]
# SIMILARITY	Belongs to the ATPase d subunit family. {ECO	0000305}.
# SUBCELLULAR LOCATION	ATP5H_HUMAN	Mitochondrion. Mitochondrion inner membrane. 
# SUBUNIT	F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity). {ECO	0000250}. 
# SUPFAM	SSF161065	SSF161065
# TopDownProteomics	O75947-1	-. [O75947-1]
# TopDownProteomics	O75947-2	-. [O75947-2]
# UCSC	uc002jmn	human. [O75947-1]
# eggNOG	ENOG4111IHJ	LUCA
# eggNOG	KOG3366	Eukaryota
BLAST	swissprot:ATP5H_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ATP5H_HUMAN
BioCyc	ZFISH:HS09654-MONOMER	http://biocyc.org/getid?id=ZFISH:HS09654-MONOMER
COXPRESdb	10476	http://coxpresdb.jp/data/gene/10476.shtml
CleanEx	HS_ATP5H	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP5H
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.140200	http://dx.doi.org/10.1101/gr.140200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF061735	http://www.ebi.ac.uk/ena/data/view/AF061735
EMBL	AF070650	http://www.ebi.ac.uk/ena/data/view/AF070650
EMBL	AF087135	http://www.ebi.ac.uk/ena/data/view/AF087135
EMBL	AK312230	http://www.ebi.ac.uk/ena/data/view/AK312230
EMBL	BC032245	http://www.ebi.ac.uk/ena/data/view/BC032245
EMBL	BC038092	http://www.ebi.ac.uk/ena/data/view/BC038092
EMBL	CH471099	http://www.ebi.ac.uk/ena/data/view/CH471099
Ensembl	ENST00000301587	http://www.ensembl.org/id/ENST00000301587
Ensembl	ENST00000344546	http://www.ensembl.org/id/ENST00000344546
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000274	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000274
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005753	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005753
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0015078	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015078
GO_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GO_process	GO:0006754	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006754
GO_process	GO:0015986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015986
GO_process	GO:0042776	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042776
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ATP5H	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP5H
GeneID	10476	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10476
GeneTree	ENSGT00390000003582	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000003582
HGNC	HGNC:845	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:845
HOGENOM	HOG000267023	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267023&db=HOGENOM6
HOVERGEN	HBG050612	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050612&db=HOVERGEN
HPA	HPA042777	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042777
HPA	HPA048459	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA048459
InParanoid	O75947	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O75947
IntAct	O75947	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O75947*
InterPro	IPR008689	http://www.ebi.ac.uk/interpro/entry/IPR008689
Jabion	10476	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10476
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:10476	http://www.genome.jp/dbget-bin/www_bget?hsa:10476
KEGG_Orthology	KO:K02138	http://www.genome.jp/dbget-bin/www_bget?KO:K02138
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MINT	MINT-1407327	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1407327
OMA	PYPQDKV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PYPQDKV
OrthoDB	EOG091G0MQA	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0MQA
PANTHER	PTHR12700	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12700
PSORT	swissprot:ATP5H_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ATP5H_HUMAN
PSORT-B	swissprot:ATP5H_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ATP5H_HUMAN
PSORT2	swissprot:ATP5H_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ATP5H_HUMAN
PharmGKB	PA25135	http://www.pharmgkb.org/do/serve?objId=PA25135&objCls=Gene
Phobius	swissprot:ATP5H_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ATP5H_HUMAN
PhylomeDB	O75947	http://phylomedb.org/?seqid=O75947
ProteinModelPortal	O75947	http://www.proteinmodelportal.org/query/uniprot/O75947
PubMed	11042152	http://www.ncbi.nlm.nih.gov/pubmed/11042152
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-163210	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-163210
RefSeq	NP_001003785	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001003785
RefSeq	NP_006347	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006347
SMR	O75947	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O75947
STRING	9606.ENSP00000301587	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000301587&targetmode=cogs
SUPFAM	SSF161065	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161065
UCSC	uc002jmn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002jmn&org=rat
UniGene	Hs.514465	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.514465
UniProtKB	ATP5H_HUMAN	http://www.uniprot.org/uniprot/ATP5H_HUMAN
UniProtKB-AC	O75947	http://www.uniprot.org/uniprot/O75947
charge	swissprot:ATP5H_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ATP5H_HUMAN
eggNOG	ENOG4111IHJ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111IHJ
eggNOG	KOG3366	http://eggnogapi.embl.de/nog_data/html/tree/KOG3366
epestfind	swissprot:ATP5H_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ATP5H_HUMAN
garnier	swissprot:ATP5H_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ATP5H_HUMAN
helixturnhelix	swissprot:ATP5H_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATP5H_HUMAN
hmoment	swissprot:ATP5H_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ATP5H_HUMAN
iep	swissprot:ATP5H_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ATP5H_HUMAN
inforesidue	swissprot:ATP5H_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ATP5H_HUMAN
neXtProt	NX_O75947	http://www.nextprot.org/db/entry/NX_O75947
octanol	swissprot:ATP5H_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ATP5H_HUMAN
pepcoil	swissprot:ATP5H_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ATP5H_HUMAN
pepdigest	swissprot:ATP5H_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ATP5H_HUMAN
pepinfo	swissprot:ATP5H_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ATP5H_HUMAN
pepnet	swissprot:ATP5H_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ATP5H_HUMAN
pepstats	swissprot:ATP5H_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ATP5H_HUMAN
pepwheel	swissprot:ATP5H_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ATP5H_HUMAN
pepwindow	swissprot:ATP5H_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ATP5H_HUMAN
sigcleave	swissprot:ATP5H_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ATP5H_HUMAN
## Database	ID	URL or Descriptions
# AltName	GBRT_HUMAN	GABA(A) receptor subunit theta
# DrugBank	DB00186	Lorazepam
# DrugBank	DB00189	Ethchlorvynol
# DrugBank	DB00228	Enflurane
# DrugBank	DB00231	Temazepam
# DrugBank	DB00237	Butabarbital
# DrugBank	DB00241	Butalbital
# DrugBank	DB00273	Topiramate
# DrugBank	DB00292	Etomidate
# DrugBank	DB00306	Talbutal
# DrugBank	DB00312	Pentobarbital
# DrugBank	DB00334	Olanzapine
# DrugBank	DB00349	Clobazam
# DrugBank	DB00371	Meprobamate
# DrugBank	DB00402	Eszopiclone
# DrugBank	DB00404	Alprazolam
# DrugBank	DB00475	Chlordiazepoxide
# DrugBank	DB00543	Amoxapine
# DrugBank	DB00628	Clorazepate
# DrugBank	DB00659	Acamprosate
# DrugBank	DB00683	Midazolam
# DrugBank	DB00690	Flurazepam
# DrugBank	DB00753	Isoflurane
# DrugBank	DB00794	Primidone
# DrugBank	DB00801	Halazepam
# DrugBank	DB00818	Propofol
# DrugBank	DB00829	Diazepam
# DrugBank	DB00842	Oxazepam
# DrugBank	DB00897	Triazolam
# DrugBank	DB00898	Ethanol
# DrugBank	DB01028	Methoxyflurane
# DrugBank	DB01049	Ergoloid mesylate
# DrugBank	DB01068	Clonazepam
# DrugBank	DB01107	Methyprylon
# DrugBank	DB01159	Halothane
# DrugBank	DB01189	Desflurane
# DrugBank	DB01205	Flumazenil
# DrugBank	DB01215	Estazolam
# DrugBank	DB01236	Sevoflurane
# DrugBank	DB01437	Glutethimide
# DrugBank	DB01558	Bromazepam
# DrugBank	DB01588	Prazepam
# DrugBank	DB01589	Quazepam
# DrugBank	DB01595	Nitrazepam
# Ensembl	ENST00000598523	ENSP00000469332; ENSG00000268089
# FUNCTION	GBRT_HUMAN	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0043235	receptor complex; IDA:MGI.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:1902711	GABA-A receptor complex; IBA:GO_Central.
# GO_function	GO:0004888	transmembrane signaling receptor activity; TAS:ProtInc.
# GO_function	GO:0004890	GABA-A receptor activity; IEA:InterPro.
# GO_function	GO:0005230	extracellular ligand-gated ion channel activity; IEA:InterPro.
# GO_function	GO:0005254	chloride channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0005326	neurotransmitter transporter activity; TAS:ProtInc.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.70.170.10	-; 1.
# Genevisible	Q9UN88	HS
# HGNC	HGNC:14454	GABRQ
# InterPro	IPR006028	GABAA/Glycine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR008101	GABAAt_rcpt
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04727	GABAergic synapse
# KEGG_Pathway	ko05032	Morphine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# MIM	300349	gene
# Organism	GBRT_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR18945	PTHR18945; 3
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00253	GABAARECEPTR
# PRINTS	PR01725	GABAARTHETA
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-112314	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
# Reactome	R-HSA-975298	Ligand-gated ion channel transport
# Reactome	R-HSA-977441	GABA A receptor activation
# RecName	GBRT_HUMAN	Gamma-aminobutyric acid receptor subunit theta
# RefSeq	NP_061028	NM_018558.3
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRQ sub-subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	GBRT_HUMAN	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	GBRT_HUMAN	Generally pentameric. This subunit coassembles with alpha-2, beta-1 and gamma-1. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112; 2
# TIGRFAMs	TIGR00860	LIC
# UCSC	uc004ffp	human
# eggNOG	ENOG410XPWH	LUCA
# eggNOG	KOG3643	Eukaryota
BLAST	swissprot:GBRT_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GBRT_HUMAN
BioCyc	ZFISH:ENSG00000147402-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000147402-MONOMER
COXPRESdb	55879	http://coxpresdb.jp/data/gene/55879.shtml
CleanEx	HS_GABRQ	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GABRQ
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1073/pnas.96.17.9891	http://dx.doi.org/10.1073/pnas.96.17.9891
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00186	http://www.drugbank.ca/drugs/DB00186
DrugBank	DB00189	http://www.drugbank.ca/drugs/DB00189
DrugBank	DB00228	http://www.drugbank.ca/drugs/DB00228
DrugBank	DB00231	http://www.drugbank.ca/drugs/DB00231
DrugBank	DB00237	http://www.drugbank.ca/drugs/DB00237
DrugBank	DB00241	http://www.drugbank.ca/drugs/DB00241
DrugBank	DB00273	http://www.drugbank.ca/drugs/DB00273
DrugBank	DB00292	http://www.drugbank.ca/drugs/DB00292
DrugBank	DB00306	http://www.drugbank.ca/drugs/DB00306
DrugBank	DB00312	http://www.drugbank.ca/drugs/DB00312
DrugBank	DB00334	http://www.drugbank.ca/drugs/DB00334
DrugBank	DB00349	http://www.drugbank.ca/drugs/DB00349
DrugBank	DB00371	http://www.drugbank.ca/drugs/DB00371
DrugBank	DB00402	http://www.drugbank.ca/drugs/DB00402
DrugBank	DB00404	http://www.drugbank.ca/drugs/DB00404
DrugBank	DB00475	http://www.drugbank.ca/drugs/DB00475
DrugBank	DB00543	http://www.drugbank.ca/drugs/DB00543
DrugBank	DB00628	http://www.drugbank.ca/drugs/DB00628
DrugBank	DB00659	http://www.drugbank.ca/drugs/DB00659
DrugBank	DB00683	http://www.drugbank.ca/drugs/DB00683
DrugBank	DB00690	http://www.drugbank.ca/drugs/DB00690
DrugBank	DB00753	http://www.drugbank.ca/drugs/DB00753
DrugBank	DB00794	http://www.drugbank.ca/drugs/DB00794
DrugBank	DB00801	http://www.drugbank.ca/drugs/DB00801
DrugBank	DB00818	http://www.drugbank.ca/drugs/DB00818
DrugBank	DB00829	http://www.drugbank.ca/drugs/DB00829
DrugBank	DB00842	http://www.drugbank.ca/drugs/DB00842
DrugBank	DB00897	http://www.drugbank.ca/drugs/DB00897
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01028	http://www.drugbank.ca/drugs/DB01028
DrugBank	DB01049	http://www.drugbank.ca/drugs/DB01049
DrugBank	DB01068	http://www.drugbank.ca/drugs/DB01068
DrugBank	DB01107	http://www.drugbank.ca/drugs/DB01107
DrugBank	DB01159	http://www.drugbank.ca/drugs/DB01159
DrugBank	DB01189	http://www.drugbank.ca/drugs/DB01189
DrugBank	DB01205	http://www.drugbank.ca/drugs/DB01205
DrugBank	DB01215	http://www.drugbank.ca/drugs/DB01215
DrugBank	DB01236	http://www.drugbank.ca/drugs/DB01236
DrugBank	DB01437	http://www.drugbank.ca/drugs/DB01437
DrugBank	DB01558	http://www.drugbank.ca/drugs/DB01558
DrugBank	DB01588	http://www.drugbank.ca/drugs/DB01588
DrugBank	DB01589	http://www.drugbank.ca/drugs/DB01589
DrugBank	DB01595	http://www.drugbank.ca/drugs/DB01595
EMBL	AF002997	http://www.ebi.ac.uk/ena/data/view/AF002997
EMBL	AF144648	http://www.ebi.ac.uk/ena/data/view/AF144648
EMBL	AF189259	http://www.ebi.ac.uk/ena/data/view/AF189259
EMBL	BC109210	http://www.ebi.ac.uk/ena/data/view/BC109210
EMBL	BC109211	http://www.ebi.ac.uk/ena/data/view/BC109211
EMBL	CH471169	http://www.ebi.ac.uk/ena/data/view/CH471169
Ensembl	ENST00000598523	http://www.ensembl.org/id/ENST00000598523
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0043235	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043235
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_component	GO:1902711	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902711
GO_function	GO:0004888	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004888
GO_function	GO:0004890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004890
GO_function	GO:0005230	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005230
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0005326	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005326
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	GABRQ	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GABRQ
GeneID	55879	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55879
H-InvDB	HIX0056145	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0056145
HGNC	HGNC:14454	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14454
HOGENOM	HOG000049189	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000049189&db=HOGENOM6
HOVERGEN	HBG051708	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051708&db=HOVERGEN
HPA	HPA002063	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA002063
InParanoid	Q9UN88	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UN88
InterPro	IPR006028	http://www.ebi.ac.uk/interpro/entry/IPR006028
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR008101	http://www.ebi.ac.uk/interpro/entry/IPR008101
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
Jabion	55879	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55879
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:55879	http://www.genome.jp/dbget-bin/www_bget?hsa:55879
KEGG_Orthology	KO:K05192	http://www.genome.jp/dbget-bin/www_bget?KO:K05192
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
KEGG_Pathway	ko05032	http://www.genome.jp/kegg-bin/show_pathway?ko05032
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
MIM	300349	http://www.ncbi.nlm.nih.gov/omim/300349
OrthoDB	EOG091G0805	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0805
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00253	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00253
PRINTS	PR01725	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01725
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:GBRT_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GBRT_HUMAN
PSORT-B	swissprot:GBRT_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GBRT_HUMAN
PSORT2	swissprot:GBRT_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GBRT_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA28504	http://www.pharmgkb.org/do/serve?objId=PA28504&objCls=Gene
Phobius	swissprot:GBRT_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GBRT_HUMAN
PhylomeDB	Q9UN88	http://phylomedb.org/?seqid=Q9UN88
ProteinModelPortal	Q9UN88	http://www.proteinmodelportal.org/query/uniprot/Q9UN88
PubMed	10449790	http://www.ncbi.nlm.nih.gov/pubmed/10449790
PubMed	10804200	http://www.ncbi.nlm.nih.gov/pubmed/10804200
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
Reactome	R-HSA-112314	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112314
Reactome	R-HSA-975298	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-975298
Reactome	R-HSA-977441	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-977441
RefSeq	NP_061028	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061028
SMR	Q9UN88	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9UN88
STRING	9606.ENSP00000359329	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000359329&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc004ffp	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004ffp&org=rat
UniGene	Hs.283081	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.283081
UniProtKB	GBRT_HUMAN	http://www.uniprot.org/uniprot/GBRT_HUMAN
UniProtKB-AC	Q9UN88	http://www.uniprot.org/uniprot/Q9UN88
charge	swissprot:GBRT_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GBRT_HUMAN
eggNOG	ENOG410XPWH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPWH
eggNOG	KOG3643	http://eggnogapi.embl.de/nog_data/html/tree/KOG3643
epestfind	swissprot:GBRT_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GBRT_HUMAN
garnier	swissprot:GBRT_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GBRT_HUMAN
helixturnhelix	swissprot:GBRT_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GBRT_HUMAN
hmoment	swissprot:GBRT_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GBRT_HUMAN
iep	swissprot:GBRT_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GBRT_HUMAN
inforesidue	swissprot:GBRT_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GBRT_HUMAN
neXtProt	NX_Q9UN88	http://www.nextprot.org/db/entry/NX_Q9UN88
octanol	swissprot:GBRT_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GBRT_HUMAN
pepcoil	swissprot:GBRT_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GBRT_HUMAN
pepdigest	swissprot:GBRT_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GBRT_HUMAN
pepinfo	swissprot:GBRT_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GBRT_HUMAN
pepnet	swissprot:GBRT_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GBRT_HUMAN
pepstats	swissprot:GBRT_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GBRT_HUMAN
pepwheel	swissprot:GBRT_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GBRT_HUMAN
pepwindow	swissprot:GBRT_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GBRT_HUMAN
sigcleave	swissprot:GBRT_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GBRT_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TTYH3_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9C0H2-1; Sequence=Displayed; Name=2; IsoId=Q9C0H2-2; Sequence=VSP_029770; Note=No experimental confirmation available.; Name=3; IsoId=Q9C0H2-3; Sequence=VSP_029769; Note=No experimental confirmation available.; Name=4; IsoId=Q9C0H2-4; Sequence=VSP_042220; Note=No experimental confirmation available.; 
# BioGrid	123277	25
# CCDS	CCDS34588	-. [Q9C0H2-1]
# CDD	cd07912	Tweety_N
# ChiTaRS	TTYH3	human
# Ensembl	ENST00000258796	ENSP00000258796; ENSG00000136295. [Q9C0H2-1]
# Ensembl	ENST00000403167	ENSP00000385015; ENSG00000136295. [Q9C0H2-3]
# Ensembl	ENST00000407643	ENSP00000385316; ENSG00000136295. [Q9C0H2-2]
# ExpressionAtlas	Q9C0H2	baseline and differential
# FUNCTION	TTYH3_HUMAN	Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. {ECO 0000269|PubMed 15010458}. 
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005229	intracellular calcium activated chloride channel activity; IDA:FlyBase.
# GO_function	GO:0005254	chloride channel activity; IMP:UniProtKB.
# GO_process	GO:0006821	chloride transport; IDA:FlyBase.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9C0H2	HS
# HGNC	HGNC:22222	TTYH3
# IntAct	Q9C0H2	3
# InterPro	IPR006990	Tweety
# MIM	608919	gene
# MISCELLANEOUS	TTYH3_HUMAN	The current is completely inhibited by the addition of an anion permeability inhibitor. Addition of a Ca(2+) ionophore induces an outward-rectified current in mock-transfected cells, but it introduced an overt linear current in TTYH3-transfected cells. 
# Organism	TTYH3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12424	PTHR12424
# PTM	TTYH3_HUMAN	N-glycosylated. {ECO 0000269|PubMed 15010458, ECO 0000269|PubMed 19159218}. 
# Pfam	PF04906	Tweety
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	TTYH3_HUMAN	Protein tweety homolog 3
# RefSeq	NP_079526	NM_025250.2. [Q9C0H2-1]
# RefSeq	XP_011513837	XM_011515535.2. [Q9C0H2-4]
# RefSeq	XP_016868145	XM_017012656.1. [Q9C0H2-2]
# SEQUENCE CAUTION	Sequence=BAB21782.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAL23958.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the tweety family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	TTYH3_HUMAN	Cell membrane {ECO 0000269|PubMed 15010458}; Multi-pass membrane protein {ECO 0000269|PubMed 15010458}. 
# TCDB	1.A.48.1	the anion channel tweety (tweety) family
# TISSUE SPECIFICITY	Expressed in excitable tissues. Expressed in the brain, heart, skeletal muscle, colon, spleen, kidney and peripheral blood leukocytes. {ECO:0000269|PubMed	15010458}. 
# UCSC	uc003smp	human. [Q9C0H2-1]
# eggNOG	ENOG410ZNTN	LUCA
# eggNOG	KOG4433	Eukaryota
BLAST	swissprot:TTYH3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TTYH3_HUMAN
COXPRESdb	80727	http://coxpresdb.jp/data/gene/80727.shtml
CleanEx	HS_TTYH3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TTYH3
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1021/pr0705441	http://dx.doi.org/10.1021/pr0705441
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M313813200	http://dx.doi.org/10.1074/jbc.M313813200
DOI	10.1093/dnares/10.1.49	http://dx.doi.org/10.1093/dnares/10.1.49
DOI	10.1093/dnares/7.6.347	http://dx.doi.org/10.1093/dnares/7.6.347
DOI	10.1093/dnares/9.3.99	http://dx.doi.org/10.1093/dnares/9.3.99
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1083423	http://dx.doi.org/10.1126/science.1083423
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
EMBL	AB051478	http://www.ebi.ac.uk/ena/data/view/AB051478
EMBL	AB162931	http://www.ebi.ac.uk/ena/data/view/AB162931
EMBL	AC006028	http://www.ebi.ac.uk/ena/data/view/AC006028
EMBL	AC073462	http://www.ebi.ac.uk/ena/data/view/AC073462
EMBL	AK074158	http://www.ebi.ac.uk/ena/data/view/AK074158
EMBL	AK124608	http://www.ebi.ac.uk/ena/data/view/AK124608
EMBL	BC131824	http://www.ebi.ac.uk/ena/data/view/BC131824
EMBL	BC152447	http://www.ebi.ac.uk/ena/data/view/BC152447
EMBL	BE263005	http://www.ebi.ac.uk/ena/data/view/BE263005
EMBL	CH236953	http://www.ebi.ac.uk/ena/data/view/CH236953
EMBL	CH471144	http://www.ebi.ac.uk/ena/data/view/CH471144
Ensembl	ENST00000258796	http://www.ensembl.org/id/ENST00000258796
Ensembl	ENST00000403167	http://www.ensembl.org/id/ENST00000403167
Ensembl	ENST00000407643	http://www.ensembl.org/id/ENST00000407643
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005229	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005229
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_process	GO:0006821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006821
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	TTYH3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TTYH3
GeneID	80727	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80727
GeneTree	ENSGT00390000010182	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000010182
HGNC	HGNC:22222	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:22222
HOGENOM	HOG000070449	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000070449&db=HOGENOM6
HOVERGEN	HBG108621	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108621&db=HOVERGEN
HPA	HPA053520	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA053520
InParanoid	Q9C0H2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9C0H2
IntAct	Q9C0H2	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9C0H2*
InterPro	IPR006990	http://www.ebi.ac.uk/interpro/entry/IPR006990
Jabion	80727	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=80727
KEGG_Gene	hsa:80727	http://www.genome.jp/dbget-bin/www_bget?hsa:80727
MIM	608919	http://www.ncbi.nlm.nih.gov/omim/608919
OMA	LIRNSKA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LIRNSKA
OrthoDB	EOG091G05MR	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05MR
PANTHER	PTHR12424	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12424
PSORT	swissprot:TTYH3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TTYH3_HUMAN
PSORT-B	swissprot:TTYH3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TTYH3_HUMAN
PSORT2	swissprot:TTYH3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TTYH3_HUMAN
Pfam	PF04906	http://pfam.xfam.org/family/PF04906
PharmGKB	PA134908427	http://www.pharmgkb.org/do/serve?objId=PA134908427&objCls=Gene
Phobius	swissprot:TTYH3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TTYH3_HUMAN
PhylomeDB	Q9C0H2	http://phylomedb.org/?seqid=Q9C0H2
ProteinModelPortal	Q9C0H2	http://www.proteinmodelportal.org/query/uniprot/Q9C0H2
PubMed	11214970	http://www.ncbi.nlm.nih.gov/pubmed/11214970
PubMed	12168954	http://www.ncbi.nlm.nih.gov/pubmed/12168954
PubMed	12690205	http://www.ncbi.nlm.nih.gov/pubmed/12690205
PubMed	12693554	http://www.ncbi.nlm.nih.gov/pubmed/12693554
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15010458	http://www.ncbi.nlm.nih.gov/pubmed/15010458
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	18220336	http://www.ncbi.nlm.nih.gov/pubmed/18220336
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_079526	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_079526
RefSeq	XP_011513837	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011513837
RefSeq	XP_016868145	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016868145
STRING	9606.ENSP00000258796	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000258796&targetmode=cogs
TCDB	1.A.48.1	http://www.tcdb.org/search/result.php?tc=1.A.48.1
UCSC	uc003smp	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003smp&org=rat
UniGene	Hs.440899	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.440899
UniProtKB	TTYH3_HUMAN	http://www.uniprot.org/uniprot/TTYH3_HUMAN
UniProtKB-AC	Q9C0H2	http://www.uniprot.org/uniprot/Q9C0H2
charge	swissprot:TTYH3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TTYH3_HUMAN
eggNOG	ENOG410ZNTN	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZNTN
eggNOG	KOG4433	http://eggnogapi.embl.de/nog_data/html/tree/KOG4433
epestfind	swissprot:TTYH3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TTYH3_HUMAN
garnier	swissprot:TTYH3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TTYH3_HUMAN
helixturnhelix	swissprot:TTYH3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TTYH3_HUMAN
hmoment	swissprot:TTYH3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TTYH3_HUMAN
iep	swissprot:TTYH3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TTYH3_HUMAN
inforesidue	swissprot:TTYH3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TTYH3_HUMAN
neXtProt	NX_Q9C0H2	http://www.nextprot.org/db/entry/NX_Q9C0H2
octanol	swissprot:TTYH3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TTYH3_HUMAN
pepcoil	swissprot:TTYH3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TTYH3_HUMAN
pepdigest	swissprot:TTYH3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TTYH3_HUMAN
pepinfo	swissprot:TTYH3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TTYH3_HUMAN
pepnet	swissprot:TTYH3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TTYH3_HUMAN
pepstats	swissprot:TTYH3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TTYH3_HUMAN
pepwheel	swissprot:TTYH3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TTYH3_HUMAN
pepwindow	swissprot:TTYH3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TTYH3_HUMAN
sigcleave	swissprot:TTYH3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TTYH3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ABCCB_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96J66-1; Sequence=Displayed; Name=2; Synonyms=Isoform A; IsoId=Q96J66-2; Sequence=VSP_017351; 
# AltName	ABCCB_HUMAN	Multidrug resistance-associated protein 8
# CCDS	CCDS10732	-. [Q96J66-1]
# CCDS	CCDS10733	-. [Q96J66-2]
# DrugBank	DB00158	Folic Acid
# DrugBank	DB00286	Conjugated Estrogens
# DrugBank	DB00328	Indomethacin
# DrugBank	DB00563	Methotrexate
# DrugBank	DB01032	Probenecid
# Ensembl	ENST00000353782	ENSP00000311326; ENSG00000121270. [Q96J66-2]
# Ensembl	ENST00000356608	ENSP00000349017; ENSG00000121270. [Q96J66-1]
# Ensembl	ENST00000394747	ENSP00000378230; ENSG00000121270. [Q96J66-1]
# Ensembl	ENST00000394748	ENSP00000378231; ENSG00000121270. [Q96J66-1]
# ExpressionAtlas	Q96J66	baseline and differential
# FUNCTION	ABCCB_HUMAN	Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Probably functions to secrete earwax. {ECO 0000269|PubMed 12764137, ECO 0000269|PubMed 15537867, ECO 0000269|PubMed 16444273}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0008514	organic anion transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015216	purine nucleotide transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0043225	ATPase-coupled anion transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0015711	organic anion transport; IDA:UniProtKB.
# GO_process	GO:0015865	purine nucleotide transport; IDA:UniProtKB.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 2.
# Genevisible	Q96J66	HS
# HGNC	HGNC:14639	ABCC11
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR011527	ABC1_TM_dom
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR027417	P-loop_NTPase
# InterPro	IPR030251	ABCC11
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko02010	ABC transporters
# MIM	117800	phenotype
# MIM	607040	gene
# Organism	ABCCB_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR24223:SF168	PTHR24223:SF168; 2
# POLYMORPHISM	The allele with Arg-180 is responsible for the dry earwax phenotype [MIM:117800]. Human earwax is a Mendelian trait consisting of wet and dry types. The wet earwax is brownish and sticky, whereas the dry type lacks cerumen. The wet cerumen phenotype is completely dominant. The dry type is seen frequently (80-95%) among East Asians, but uncommon (0-3%) in populations of European and African origins. Intermediate frequencies (30-50%) of the dry type are seen in populations of Southern Asia, the Pacific Islands, Central Asia and Asia Minor, as well as among the Native North American and Inuit of Asian ancestry. {ECO	0000269|PubMed:16444273}. 
# PROSITE	PS00211	ABC_TRANSPORTER_1; 2
# PROSITE	PS50893	ABC_TRANSPORTER_2; 2
# PROSITE	PS50929	ABC_TM1F; 2
# Pfam	PF00005	ABC_tran; 2
# Pfam	PF00664	ABC_membrane; 2
# Proteomes	UP000005640	Chromosome 16
# Reactome	R-HSA-382556	ABC-family proteins mediated transport
# RecName	ABCCB_HUMAN	ATP-binding cassette sub-family C member 11
# RefSeq	NP_115972	NM_032583.3. [Q96J66-1]
# RefSeq	NP_149163	NM_033151.3. [Q96J66-1]
# RefSeq	NP_660187	NM_145186.2. [Q96J66-2]
# RefSeq	XP_016879284	XM_017023795.1. [Q96J66-1]
# RefSeq	XP_016879285	XM_017023796.1. [Q96J66-1]
# RefSeq	XP_016879286	XM_017023797.1. [Q96J66-1]
# RefSeq	XP_016879287	XM_017023798.1. [Q96J66-1]
# RefSeq	XP_016879288	XM_017023799.1. [Q96J66-1]
# RefSeq	XP_016879289	XM_017023800.1. [Q96J66-1]
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 2 ABC transmembrane type-1 domains. {ECO:0000255|PROSITE-ProRule	PRU00441}. 
# SIMILARITY	Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA; 2
# SUBCELLULAR LOCATION	ABCCB_HUMAN	Membrane; Multi-pass membrane protein. 
# SUPFAM	SSF52540	SSF52540; 2
# SUPFAM	SSF90123	SSF90123; 2
# TCDB	3.A.1.208.13	the atp-binding cassette (abc) superfamily
# TISSUE SPECIFICITY	ABCCB_HUMAN	Expressed in many tissues. Not expressed in kidney, spleen and colon. Highly expressed in breast cancer. Expressed at moderate levels in normal breast and testis and at very low levels in liver, brain and placenta. {ECO 0000269|PubMed 11483364, ECO 0000269|PubMed 11591886}. 
# UCSC	uc002eff	human. [Q96J66-1]
# WEB RESOURCE	ABCCB_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=Q96J66";
# WEB RESOURCE	ABCCB_HUMAN	Name=Protein Spotlight; Note=Of earwax and migration - Issue 67 of February 2006; URL="http //web.expasy.org/spotlight/back_issues/067"; 
# eggNOG	COG1132	LUCA
# eggNOG	KOG0054	Eukaryota
BLAST	swissprot:ABCCB_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCCB_HUMAN
COXPRESdb	85320	http://coxpresdb.jp/data/gene/85320.shtml
CleanEx	HS_ABCC11	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCC11
DOI	10.1006/bbrc.2001.5865	http://dx.doi.org/10.1006/bbrc.2001.5865
DOI	10.1016/S0378-1119(01)00572-8	http://dx.doi.org/10.1016/S0378-1119(01)00572-8
DOI	10.1038/ng1733	http://dx.doi.org/10.1038/ng1733
DOI	10.1074/jbc.M304059200	http://dx.doi.org/10.1074/jbc.M304059200
DOI	10.1124/mol.104.007138	http://dx.doi.org/10.1124/mol.104.007138
DrugBank	DB00158	http://www.drugbank.ca/drugs/DB00158
DrugBank	DB00286	http://www.drugbank.ca/drugs/DB00286
DrugBank	DB00328	http://www.drugbank.ca/drugs/DB00328
DrugBank	DB00563	http://www.drugbank.ca/drugs/DB00563
DrugBank	DB01032	http://www.drugbank.ca/drugs/DB01032
EMBL	AF352582	http://www.ebi.ac.uk/ena/data/view/AF352582
EMBL	AF367202	http://www.ebi.ac.uk/ena/data/view/AF367202
EMBL	AF411579	http://www.ebi.ac.uk/ena/data/view/AF411579
EMBL	AY040219	http://www.ebi.ac.uk/ena/data/view/AY040219
Ensembl	ENST00000353782	http://www.ensembl.org/id/ENST00000353782
Ensembl	ENST00000356608	http://www.ensembl.org/id/ENST00000356608
Ensembl	ENST00000394747	http://www.ensembl.org/id/ENST00000394747
Ensembl	ENST00000394748	http://www.ensembl.org/id/ENST00000394748
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0008514	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008514
GO_function	GO:0015216	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015216
GO_function	GO:0043225	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043225
GO_process	GO:0015711	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015711
GO_process	GO:0015865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015865
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCC11	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCC11
GeneID	85320	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=85320
GeneTree	ENSGT00860000133687	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00860000133687
HGNC	HGNC:14639	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14639
HOVERGEN	HBG108314	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108314&db=HOVERGEN
HPA	CAB032513	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB032513
HPA	HPA031980	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031980
HPA	HPA031981	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031981
HPA	HPA031982	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031982
InParanoid	Q96J66	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96J66
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR011527	http://www.ebi.ac.uk/interpro/entry/IPR011527
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
InterPro	IPR030251	http://www.ebi.ac.uk/interpro/entry/IPR030251
Jabion	85320	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=85320
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:85320	http://www.genome.jp/dbget-bin/www_bget?hsa:85320
KEGG_Orthology	KO:K05671	http://www.genome.jp/dbget-bin/www_bget?KO:K05671
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
MIM	117800	http://www.ncbi.nlm.nih.gov/omim/117800
MIM	607040	http://www.ncbi.nlm.nih.gov/omim/607040
OMA	SFWWLSY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SFWWLSY
OrthoDB	EOG091G01TC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01TC
PANTHER	PTHR24223:SF168	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24223:SF168
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PROSITE	PS50929	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929
PSORT	swissprot:ABCCB_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCCB_HUMAN
PSORT-B	swissprot:ABCCB_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCCB_HUMAN
PSORT2	swissprot:ABCCB_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCCB_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF00664	http://pfam.xfam.org/family/PF00664
PharmGKB	PA24393	http://www.pharmgkb.org/do/serve?objId=PA24393&objCls=Gene
Phobius	swissprot:ABCCB_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCCB_HUMAN
PhylomeDB	Q96J66	http://phylomedb.org/?seqid=Q96J66
ProteinModelPortal	Q96J66	http://www.proteinmodelportal.org/query/uniprot/Q96J66
PubMed	11483364	http://www.ncbi.nlm.nih.gov/pubmed/11483364
PubMed	11591886	http://www.ncbi.nlm.nih.gov/pubmed/11591886
PubMed	11688999	http://www.ncbi.nlm.nih.gov/pubmed/11688999
PubMed	12764137	http://www.ncbi.nlm.nih.gov/pubmed/12764137
PubMed	15537867	http://www.ncbi.nlm.nih.gov/pubmed/15537867
PubMed	16444273	http://www.ncbi.nlm.nih.gov/pubmed/16444273
Reactome	R-HSA-382556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-382556
RefSeq	NP_115972	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_115972
RefSeq	NP_149163	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_149163
RefSeq	NP_660187	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_660187
RefSeq	XP_016879284	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016879284
RefSeq	XP_016879285	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016879285
RefSeq	XP_016879286	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016879286
RefSeq	XP_016879287	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016879287
RefSeq	XP_016879288	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016879288
RefSeq	XP_016879289	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016879289
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	Q96J66	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q96J66
STRING	9606.ENSP00000349017	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000349017&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
SUPFAM	SSF90123	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123
TCDB	3.A.1.208.13	http://www.tcdb.org/search/result.php?tc=3.A.1.208.13
UCSC	uc002eff	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002eff&org=rat
UniGene	Hs.652267	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.652267
UniProtKB	ABCCB_HUMAN	http://www.uniprot.org/uniprot/ABCCB_HUMAN
UniProtKB-AC	Q96J66	http://www.uniprot.org/uniprot/Q96J66
charge	swissprot:ABCCB_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCCB_HUMAN
eggNOG	COG1132	http://eggnogapi.embl.de/nog_data/html/tree/COG1132
eggNOG	KOG0054	http://eggnogapi.embl.de/nog_data/html/tree/KOG0054
epestfind	swissprot:ABCCB_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCCB_HUMAN
garnier	swissprot:ABCCB_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCCB_HUMAN
helixturnhelix	swissprot:ABCCB_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCCB_HUMAN
hmoment	swissprot:ABCCB_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCCB_HUMAN
iep	swissprot:ABCCB_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCCB_HUMAN
inforesidue	swissprot:ABCCB_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCCB_HUMAN
neXtProt	NX_Q96J66	http://www.nextprot.org/db/entry/NX_Q96J66
octanol	swissprot:ABCCB_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCCB_HUMAN
pepcoil	swissprot:ABCCB_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCCB_HUMAN
pepdigest	swissprot:ABCCB_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCCB_HUMAN
pepinfo	swissprot:ABCCB_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCCB_HUMAN
pepnet	swissprot:ABCCB_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCCB_HUMAN
pepstats	swissprot:ABCCB_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCCB_HUMAN
pepwheel	swissprot:ABCCB_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCCB_HUMAN
pepwindow	swissprot:ABCCB_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCCB_HUMAN
sigcleave	swissprot:ABCCB_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCCB_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	NCKX2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UI40-1; Sequence=Displayed; Name=2; IsoId=Q9UI40-2; Sequence=VSP_006164; 
# AltName	NCKX2_HUMAN	Na(+)/K(+)/Ca(2+)-exchange protein 2
# AltName	NCKX2_HUMAN	Retinal cone Na-Ca+K exchanger
# AltName	NCKX2_HUMAN	Solute carrier family 24 member 2
# CCDS	CCDS55297	-. [Q9UI40-2]
# CCDS	CCDS6493	-. [Q9UI40-1]
# ChiTaRS	SLC24A2	human
# Ensembl	ENST00000286344	ENSP00000286344; ENSG00000155886. [Q9UI40-2]
# Ensembl	ENST00000341998	ENSP00000344801; ENSG00000155886. [Q9UI40-1]
# FUNCTION	NCKX2_HUMAN	Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0005262	calcium channel activity; IBA:GO_Central.
# GO_function	GO:0005509	calcium ion binding; IBA:GO_Central.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_function	GO:0016151	nickel cation binding; IEA:Ensembl.
# GO_function	GO:0030145	manganese ion binding; IEA:Ensembl.
# GO_function	GO:0030955	potassium ion binding; IBA:GO_Central.
# GO_function	GO:0031402	sodium ion binding; IBA:GO_Central.
# GO_function	GO:0046870	cadmium ion binding; IEA:Ensembl.
# GO_function	NCKX2_HUMAN	GO 0008273 calcium, potassium sodium antiporter activity; IDA MGI.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006874	cellular calcium ion homeostasis; IBA:GO_Central.
# GO_process	GO:0007601	visual perception; IEA:UniProtKB-KW.
# GO_process	GO:0007612	learning; IEA:Ensembl.
# GO_process	GO:0007613	memory; IEA:Ensembl.
# GO_process	GO:0034220	ion transmembrane transport; IDA:MGI.
# GO_process	GO:0050896	response to stimulus; IEA:UniProtKB-KW.
# GO_process	GO:0060291	long-term synaptic potentiation; IBA:GO_Central.
# GO_process	GO:0060292	long term synaptic depression; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9UI40	HS
# HGNC	HGNC:10976	SLC24A2
# InterPro	IPR004481	K/Na/Ca-exchanger
# InterPro	IPR004837	NaCa_Exmemb
# KEGG_Brite	ko02001	Solute carrier family
# MIM	609838	gene
# Organism	NCKX2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10846	PTHR10846
# Pfam	PF01699	Na_Ca_ex; 2
# Proteomes	UP000005640	Chromosome 9
# Reactome	R-HSA-425561	Sodium/Calcium exchangers
# RecName	NCKX2_HUMAN	Sodium/potassium/calcium exchanger 2
# RefSeq	NP_001180217	NM_001193288.2. [Q9UI40-2]
# RefSeq	NP_065077	NM_020344.3. [Q9UI40-1]
# RefSeq	XP_005251482	XM_005251425.2. [Q9UI40-1]
# RefSeq	XP_005251483	XM_005251426.4. [Q9UI40-1]
# RefSeq	XP_006716813	XM_006716750.3. [Q9UI40-2]
# RefSeq	XP_016870081	XM_017014592.1. [Q9UI40-1]
# RefSeq	XP_016870082	XM_017014593.1. [Q9UI40-2]
# SIMILARITY	Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	NCKX2_HUMAN	Membrane; Multi-pass membrane protein. 
# TCDB	2.A.19.4.11:the ca(2+)	cation antiporter (caca) family
# TIGRFAMs	TIGR00367	TIGR00367
# UCSC	uc003zoa	human. [Q9UI40-1]
# eggNOG	ENOG410Y9YY	LUCA
# eggNOG	KOG1307	Eukaryota
BLAST	swissprot:NCKX2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NCKX2_HUMAN
BioCyc	ZFISH:ENSG00000155886-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000155886-MONOMER
COXPRESdb	25769	http://coxpresdb.jp/data/gene/25769.shtml
CleanEx	HS_SLC24A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC24A2
DOI	10.1021/bi0270788	http://dx.doi.org/10.1021/bi0270788
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF097366	http://www.ebi.ac.uk/ena/data/view/AF097366
EMBL	AF177987	http://www.ebi.ac.uk/ena/data/view/AF177987
EMBL	AL133281	http://www.ebi.ac.uk/ena/data/view/AL133281
EMBL	AL133281	http://www.ebi.ac.uk/ena/data/view/AL133281
EMBL	AL133281	http://www.ebi.ac.uk/ena/data/view/AL133281
EMBL	AL133281	http://www.ebi.ac.uk/ena/data/view/AL133281
EMBL	AL133281	http://www.ebi.ac.uk/ena/data/view/AL133281
EMBL	AL133281	http://www.ebi.ac.uk/ena/data/view/AL133281
EMBL	AL158077	http://www.ebi.ac.uk/ena/data/view/AL158077
EMBL	AL158077	http://www.ebi.ac.uk/ena/data/view/AL158077
EMBL	AL158077	http://www.ebi.ac.uk/ena/data/view/AL158077
EMBL	AL158077	http://www.ebi.ac.uk/ena/data/view/AL158077
EMBL	AL158077	http://www.ebi.ac.uk/ena/data/view/AL158077
EMBL	AL158077	http://www.ebi.ac.uk/ena/data/view/AL158077
EMBL	AL158206	http://www.ebi.ac.uk/ena/data/view/AL158206
EMBL	AL158206	http://www.ebi.ac.uk/ena/data/view/AL158206
EMBL	AL158206	http://www.ebi.ac.uk/ena/data/view/AL158206
EMBL	AL158206	http://www.ebi.ac.uk/ena/data/view/AL158206
EMBL	AL158206	http://www.ebi.ac.uk/ena/data/view/AL158206
EMBL	AL158206	http://www.ebi.ac.uk/ena/data/view/AL158206
EMBL	BC069622	http://www.ebi.ac.uk/ena/data/view/BC069622
EMBL	BC143889	http://www.ebi.ac.uk/ena/data/view/BC143889
Ensembl	ENST00000286344	http://www.ensembl.org/id/ENST00000286344
Ensembl	ENST00000341998	http://www.ensembl.org/id/ENST00000341998
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0008273	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008273
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_function	GO:0016151	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016151
GO_function	GO:0030145	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145
GO_function	GO:0030955	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030955
GO_function	GO:0031402	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031402
GO_function	GO:0046870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046870
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874
GO_process	GO:0007601	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007601
GO_process	GO:0007612	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007612
GO_process	GO:0007613	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007613
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0050896	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050896
GO_process	GO:0060291	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060291
GO_process	GO:0060292	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060292
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC24A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC24A2
GeneID	25769	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25769
GeneTree	ENSGT00760000119209	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119209
HGNC	HGNC:10976	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10976
HOGENOM	HOG000231933	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231933&db=HOGENOM6
HOVERGEN	HBG054881	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054881&db=HOVERGEN
HPA	HPA057278	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA057278
InParanoid	Q9UI40	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UI40
InterPro	IPR004481	http://www.ebi.ac.uk/interpro/entry/IPR004481
InterPro	IPR004837	http://www.ebi.ac.uk/interpro/entry/IPR004837
Jabion	25769	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=25769
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:25769	http://www.genome.jp/dbget-bin/www_bget?hsa:25769
KEGG_Orthology	KO:K13750	http://www.genome.jp/dbget-bin/www_bget?KO:K13750
MIM	609838	http://www.ncbi.nlm.nih.gov/omim/609838
OMA	SSNTWCH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SSNTWCH
OrthoDB	EOG091G0M5C	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0M5C
PANTHER	PTHR10846	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10846
PSORT	swissprot:NCKX2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NCKX2_HUMAN
PSORT-B	swissprot:NCKX2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NCKX2_HUMAN
PSORT2	swissprot:NCKX2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NCKX2_HUMAN
Pfam	PF01699	http://pfam.xfam.org/family/PF01699
PharmGKB	PA35852	http://www.pharmgkb.org/do/serve?objId=PA35852&objCls=Gene
Phobius	swissprot:NCKX2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NCKX2_HUMAN
PhylomeDB	Q9UI40	http://phylomedb.org/?seqid=Q9UI40
ProteinModelPortal	Q9UI40	http://www.proteinmodelportal.org/query/uniprot/Q9UI40
PubMed	10662833	http://www.ncbi.nlm.nih.gov/pubmed/10662833
PubMed	12600216	http://www.ncbi.nlm.nih.gov/pubmed/12600216
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-425561	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425561
RefSeq	NP_001180217	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001180217
RefSeq	NP_065077	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_065077
RefSeq	XP_005251482	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005251482
RefSeq	XP_005251483	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005251483
RefSeq	XP_006716813	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006716813
RefSeq	XP_016870081	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016870081
RefSeq	XP_016870082	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016870082
STRING	9606.ENSP00000344801	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000344801&targetmode=cogs
TCDB	2.A.19.4.11	http://www.tcdb.org/search/result.php?tc=2.A.19.4.11
TIGRFAMs	TIGR00367	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00367
UCSC	uc003zoa	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003zoa&org=rat
UniGene	Hs.283014	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.283014
UniGene	Hs.590750	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.590750
UniGene	Hs.738749	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.738749
UniProtKB	NCKX2_HUMAN	http://www.uniprot.org/uniprot/NCKX2_HUMAN
UniProtKB-AC	Q9UI40	http://www.uniprot.org/uniprot/Q9UI40
charge	swissprot:NCKX2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NCKX2_HUMAN
eggNOG	ENOG410Y9YY	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y9YY
eggNOG	KOG1307	http://eggnogapi.embl.de/nog_data/html/tree/KOG1307
epestfind	swissprot:NCKX2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NCKX2_HUMAN
garnier	swissprot:NCKX2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NCKX2_HUMAN
helixturnhelix	swissprot:NCKX2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NCKX2_HUMAN
hmoment	swissprot:NCKX2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NCKX2_HUMAN
iep	swissprot:NCKX2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NCKX2_HUMAN
inforesidue	swissprot:NCKX2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NCKX2_HUMAN
neXtProt	NX_Q9UI40	http://www.nextprot.org/db/entry/NX_Q9UI40
octanol	swissprot:NCKX2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NCKX2_HUMAN
pepcoil	swissprot:NCKX2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NCKX2_HUMAN
pepdigest	swissprot:NCKX2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NCKX2_HUMAN
pepinfo	swissprot:NCKX2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NCKX2_HUMAN
pepnet	swissprot:NCKX2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NCKX2_HUMAN
pepstats	swissprot:NCKX2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NCKX2_HUMAN
pepwheel	swissprot:NCKX2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NCKX2_HUMAN
pepwindow	swissprot:NCKX2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NCKX2_HUMAN
sigcleave	swissprot:NCKX2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NCKX2_HUMAN
## Database	ID	URL or Descriptions
# AltName	HCN2_HUMAN	Brain cyclic nucleotide-gated channel 2
# BioGrid	107081	4
# DOMAIN	HCN2_HUMAN	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. 
# ENZYME REGULATION	HCN2_HUMAN	Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. cAMP binding causes a conformation change that leads to the assembly of an active tetramer and channel opening. Channel activity is modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages. {ECO 0000269|PubMed 10228147, ECO 0000269|PubMed 22006928}. 
# Ensembl	ENST00000251287	ENSP00000251287; ENSG00000099822
# FUNCTION	HCN2_HUMAN	Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity). {ECO 0000250, ECO 0000269|PubMed 10228147, ECO 0000269|PubMed 10524219}. 
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0008076	voltage-gated potassium channel complex; TAS:ProtInc.
# GO_function	GO:0005222	intracellular cAMP activated cation channel activity; IDA:UniProtKB.
# GO_function	GO:0005248	voltage-gated sodium channel activity; IMP:UniProtKB.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IDA:UniProtKB.
# GO_function	GO:0030552	cAMP binding; IEA:UniProtKB-KW.
# GO_process	GO:0007267	cell-cell signaling; TAS:ProtInc.
# GO_process	GO:0035725	sodium ion transmembrane transport; IMP:UniProtKB.
# GO_process	GO:0042391	regulation of membrane potential; IMP:UniProtKB.
# GO_process	GO:0071320	cellular response to cAMP; IDA:UniProtKB.
# GO_process	GO:0071321	cellular response to cGMP; IDA:UniProtKB.
# GO_process	GO:0071805	potassium ion transmembrane transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.120.10	-; 1.
# Genevisible	Q9UL51	HS
# HGNC	HGNC:4846	HCN2
# INTERACTION	HCN2_HUMAN	Self; NbExp=2; IntAct=EBI-1751885, EBI-1751885; 
# IntAct	Q9UL51	5
# InterPro	IPR000595	cNMP-bd_dom
# InterPro	IPR003938	K_chnl_volt-dep_EAG/ELK/ERG
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR013621	Ion_trans_N
# InterPro	IPR014710	RmlC-like_jellyroll
# InterPro	IPR018488	cNMP-bd_CS
# InterPro	IPR018490	cNMP-bd-like
# KEGG_Brite	ko04040	Ion channels
# MIM	602781	gene
# MISCELLANEOUS	HCN2_HUMAN	Inhibited by extracellular cesium ions. 
# Organism	HCN2_HUMAN	Homo sapiens (Human)
# PDB	2MPF	NMR; -; A=521-672
# PDB	3U10	X-ray; 2.30 A; A=470-672
# PRINTS	PR01463	EAGCHANLFMLY
# PROSITE	PS00888	CNMP_BINDING_1
# PROSITE	PS50042	CNMP_BINDING_3
# PTM	HCN2_HUMAN	Phosphorylation at Ser-668 by PRKG2 shifts the voltage- dependence to more negative voltages, hence counteracting the stimulatory effect of cGMP on gating. {ECO 0000250}. 
# Pfam	PF00027	cNMP_binding
# Pfam	PF00520	Ion_trans
# Pfam	PF08412	Ion_trans_N
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-1296061	HCN channels
# RecName	HCN2_HUMAN	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
# RefSeq	NP_001185	NM_001194.3
# SIMILARITY	Belongs to the potassium channel HCN family. {ECO	0000305}. 
# SIMILARITY	Contains 1 cyclic nucleotide-binding domain. {ECO:0000255|PROSITE-ProRule	PRU00060}.
# SMART	SM00100	cNMP
# SUBCELLULAR LOCATION	HCN2_HUMAN	Cell membrane {ECO 0000269|PubMed 10228147, ECO 0000269|PubMed 10524219}; Multi-pass membrane protein {ECO 0000269|PubMed 10228147, ECO 0000269|PubMed 10524219}. 
# SUBUNIT	HCN2_HUMAN	The potassium channel is composed of a homo- or heterotetrameric complex of pore-forming subunits. Heterotetramer with HCN1. Forms an obligate 4 4 complex with accessory subunit PEX5L. Interacts with KCNE2 (By similarity). Homotetramer. {ECO 0000250, ECO 0000269|PubMed 22006928}. 
# SUPFAM	SSF51206	SSF51206
# TCDB	1.A.1.5.11	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	HCN2_HUMAN	Highly expressed throughout the brain. Detected at low levels in heart. {ECO 0000269|PubMed 10228147, ECO 0000269|PubMed 9630217}. 
# UCSC	uc002lpe	human
# eggNOG	ENOG410XPSE	LUCA
# eggNOG	KOG0498	Eukaryota
BLAST	swissprot:HCN2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:HCN2_HUMAN
COXPRESdb	610	http://coxpresdb.jp/data/gene/610.shtml
CleanEx	HS_HCN2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_HCN2
DIP	DIP-52285N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-52285N
DOI	10.1016/S0092-8674(00)81434-8	http://dx.doi.org/10.1016/S0092-8674(00)81434-8
DOI	10.1016/S0167-4781(99)00092-5	http://dx.doi.org/10.1016/S0167-4781(99)00092-5
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/jbc.M111.297606	http://dx.doi.org/10.1074/jbc.M111.297606
DOI	10.1093/emboj/18.9.2323	http://dx.doi.org/10.1093/emboj/18.9.2323
EMBL	AC004449	http://www.ebi.ac.uk/ena/data/view/AC004449
EMBL	AC005559	http://www.ebi.ac.uk/ena/data/view/AC005559
EMBL	AF064877	http://www.ebi.ac.uk/ena/data/view/AF064877
EMBL	AF065164	http://www.ebi.ac.uk/ena/data/view/AF065164
EMBL	AJ012582	http://www.ebi.ac.uk/ena/data/view/AJ012582
EMBL	AJ133727	http://www.ebi.ac.uk/ena/data/view/AJ133727
EMBL	AJ133728	http://www.ebi.ac.uk/ena/data/view/AJ133728
EMBL	AJ133729	http://www.ebi.ac.uk/ena/data/view/AJ133729
EMBL	AJ133730	http://www.ebi.ac.uk/ena/data/view/AJ133730
EMBL	AJ133731	http://www.ebi.ac.uk/ena/data/view/AJ133731
EMBL	AJ133732	http://www.ebi.ac.uk/ena/data/view/AJ133732
EMBL	AJ133733	http://www.ebi.ac.uk/ena/data/view/AJ133733
EMBL	AJ133734	http://www.ebi.ac.uk/ena/data/view/AJ133734
Ensembl	ENST00000251287	http://www.ensembl.org/id/ENST00000251287
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_function	GO:0005222	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005222
GO_function	GO:0005248	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005248
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0030552	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030552
GO_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GO_process	GO:0035725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035725
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0071320	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071320
GO_process	GO:0071321	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071321
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.120.10	http://www.cathdb.info/version/latest/superfamily/2.60.120.10
GeneCards	HCN2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=HCN2
GeneID	610	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=610
GeneTree	ENSGT00760000118772	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118772
HGNC	HGNC:4846	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4846
HOGENOM	HOG000230717	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230717&db=HOGENOM6
HOVERGEN	HBG039489	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG039489&db=HOVERGEN
InParanoid	Q9UL51	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UL51
IntAct	Q9UL51	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9UL51*
InterPro	IPR000595	http://www.ebi.ac.uk/interpro/entry/IPR000595
InterPro	IPR003938	http://www.ebi.ac.uk/interpro/entry/IPR003938
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR013621	http://www.ebi.ac.uk/interpro/entry/IPR013621
InterPro	IPR014710	http://www.ebi.ac.uk/interpro/entry/IPR014710
InterPro	IPR018488	http://www.ebi.ac.uk/interpro/entry/IPR018488
InterPro	IPR018490	http://www.ebi.ac.uk/interpro/entry/IPR018490
Jabion	610	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=610
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:610	http://www.genome.jp/dbget-bin/www_bget?hsa:610
KEGG_Orthology	KO:K04955	http://www.genome.jp/dbget-bin/www_bget?KO:K04955
MIM	602781	http://www.ncbi.nlm.nih.gov/omim/602781
OMA	MRICNIS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MRICNIS
OrthoDB	EOG091G0JQU	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0JQU
PDB	2MPF	http://www.ebi.ac.uk/pdbe-srv/view/entry/2MPF
PDB	3U10	http://www.ebi.ac.uk/pdbe-srv/view/entry/3U10
PDBsum	2MPF	http://www.ebi.ac.uk/pdbsum/2MPF
PDBsum	3U10	http://www.ebi.ac.uk/pdbsum/3U10
PRINTS	PR01463	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01463
PROSITE	PS00888	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00888
PROSITE	PS50042	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50042
PSORT	swissprot:HCN2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:HCN2_HUMAN
PSORT-B	swissprot:HCN2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:HCN2_HUMAN
PSORT2	swissprot:HCN2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:HCN2_HUMAN
Pfam	PF00027	http://pfam.xfam.org/family/PF00027
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF08412	http://pfam.xfam.org/family/PF08412
PharmGKB	PA78	http://www.pharmgkb.org/do/serve?objId=PA78&objCls=Gene
Phobius	swissprot:HCN2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:HCN2_HUMAN
PhylomeDB	Q9UL51	http://phylomedb.org/?seqid=Q9UL51
ProteinModelPortal	Q9UL51	http://www.proteinmodelportal.org/query/uniprot/Q9UL51
PubMed	10228147	http://www.ncbi.nlm.nih.gov/pubmed/10228147
PubMed	10524219	http://www.ncbi.nlm.nih.gov/pubmed/10524219
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	22006928	http://www.ncbi.nlm.nih.gov/pubmed/22006928
PubMed	9630217	http://www.ncbi.nlm.nih.gov/pubmed/9630217
Reactome	R-HSA-1296061	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296061
RefSeq	NP_001185	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001185
SMART	SM00100	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00100
SMR	Q9UL51	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9UL51
STRING	9606.ENSP00000251287	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000251287&targetmode=cogs
SUPFAM	SSF51206	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51206
TCDB	1.A.1.5.11	http://www.tcdb.org/search/result.php?tc=1.A.1.5.11
UCSC	uc002lpe	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002lpe&org=rat
UniGene	Hs.124161	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.124161
UniProtKB	HCN2_HUMAN	http://www.uniprot.org/uniprot/HCN2_HUMAN
UniProtKB-AC	Q9UL51	http://www.uniprot.org/uniprot/Q9UL51
charge	swissprot:HCN2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:HCN2_HUMAN
eggNOG	ENOG410XPSE	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPSE
eggNOG	KOG0498	http://eggnogapi.embl.de/nog_data/html/tree/KOG0498
epestfind	swissprot:HCN2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:HCN2_HUMAN
garnier	swissprot:HCN2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:HCN2_HUMAN
helixturnhelix	swissprot:HCN2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:HCN2_HUMAN
hmoment	swissprot:HCN2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:HCN2_HUMAN
iep	swissprot:HCN2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:HCN2_HUMAN
inforesidue	swissprot:HCN2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:HCN2_HUMAN
neXtProt	NX_Q9UL51	http://www.nextprot.org/db/entry/NX_Q9UL51
octanol	swissprot:HCN2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:HCN2_HUMAN
pepcoil	swissprot:HCN2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:HCN2_HUMAN
pepdigest	swissprot:HCN2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:HCN2_HUMAN
pepinfo	swissprot:HCN2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:HCN2_HUMAN
pepnet	swissprot:HCN2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:HCN2_HUMAN
pepstats	swissprot:HCN2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:HCN2_HUMAN
pepwheel	swissprot:HCN2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:HCN2_HUMAN
pepwindow	swissprot:HCN2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:HCN2_HUMAN
sigcleave	swissprot:HCN2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:HCN2_HUMAN
## Database	ID	URL or Descriptions
# Ensembl	ENST00000368599	ENSP00000357588; ENSG00000178033
# FUNCTION	FA26E_HUMAN	Pore-forming subunit of a voltage-gated ion channel. {ECO 0000250}. 
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005261	cation channel activity; IBA:GO_Central.
# GO_process	GO:0034220	ion transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q8N5C1	HS
# HGNC	HGNC:21568	FAM26E
# InterPro	IPR029569	FAM26
# InterPro	IPR029572	FAM26E
# Organism	FA26E_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR32261	PTHR32261
# PANTHER	PTHR32261:SF8	PTHR32261:SF8
# Pfam	PF14798	Ca_hom_mod
# Proteomes	UP000005640	Chromosome 6
# RecName	FA26E_HUMAN	Protein FAM26E
# RefSeq	NP_714922	NM_153711.3
# SIMILARITY	Belongs to the FAM26 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	FA26E_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# UCSC	uc003pwy	human
# eggNOG	ENOG410IEDF	Eukaryota
# eggNOG	ENOG410XQ8H	LUCA
BLAST	swissprot:FA26E_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:FA26E_HUMAN
BioCyc	ZFISH:ENSG00000178033-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000178033-MONOMER
COXPRESdb	254228	http://coxpresdb.jp/data/gene/254228.shtml
CleanEx	HS_FAM26E	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_FAM26E
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
EMBL	AK094140	http://www.ebi.ac.uk/ena/data/view/AK094140
EMBL	AK315572	http://www.ebi.ac.uk/ena/data/view/AK315572
EMBL	AL121953	http://www.ebi.ac.uk/ena/data/view/AL121953
EMBL	CH471051	http://www.ebi.ac.uk/ena/data/view/CH471051
Ensembl	ENST00000368599	http://www.ensembl.org/id/ENST00000368599
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005261	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005261
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	FAM26E	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=FAM26E
GeneID	254228	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=254228
GeneTree	ENSGT00530000062796	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062796
HGNC	HGNC:21568	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:21568
HOGENOM	HOG000294134	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294134&db=HOGENOM6
HOVERGEN	HBG056946	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG056946&db=HOVERGEN
HPA	HPA034969	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA034969
InParanoid	Q8N5C1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8N5C1
InterPro	IPR029569	http://www.ebi.ac.uk/interpro/entry/IPR029569
InterPro	IPR029572	http://www.ebi.ac.uk/interpro/entry/IPR029572
Jabion	254228	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=254228
KEGG_Gene	hsa:254228	http://www.genome.jp/dbget-bin/www_bget?hsa:254228
OMA	QKTAIGY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QKTAIGY
OrthoDB	EOG091G0BN1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0BN1
PANTHER	PTHR32261	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32261
PANTHER	PTHR32261:SF8	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32261:SF8
PSORT	swissprot:FA26E_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:FA26E_HUMAN
PSORT-B	swissprot:FA26E_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:FA26E_HUMAN
PSORT2	swissprot:FA26E_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:FA26E_HUMAN
Pfam	PF14798	http://pfam.xfam.org/family/PF14798
PharmGKB	PA162387635	http://www.pharmgkb.org/do/serve?objId=PA162387635&objCls=Gene
Phobius	swissprot:FA26E_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:FA26E_HUMAN
PhylomeDB	Q8N5C1	http://phylomedb.org/?seqid=Q8N5C1
ProteinModelPortal	Q8N5C1	http://www.proteinmodelportal.org/query/uniprot/Q8N5C1
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
RefSeq	NP_714922	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_714922
SMR	Q8N5C1	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8N5C1
UCSC	uc003pwy	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003pwy&org=rat
UniGene	Hs.105081	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.105081
UniGene	Hs.660142	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.660142
UniProtKB	FA26E_HUMAN	http://www.uniprot.org/uniprot/FA26E_HUMAN
UniProtKB-AC	Q8N5C1	http://www.uniprot.org/uniprot/Q8N5C1
charge	swissprot:FA26E_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:FA26E_HUMAN
eggNOG	ENOG410IEDF	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IEDF
eggNOG	ENOG410XQ8H	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ8H
epestfind	swissprot:FA26E_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:FA26E_HUMAN
garnier	swissprot:FA26E_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:FA26E_HUMAN
helixturnhelix	swissprot:FA26E_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:FA26E_HUMAN
hmoment	swissprot:FA26E_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:FA26E_HUMAN
iep	swissprot:FA26E_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:FA26E_HUMAN
inforesidue	swissprot:FA26E_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:FA26E_HUMAN
neXtProt	NX_Q8N5C1	http://www.nextprot.org/db/entry/NX_Q8N5C1
octanol	swissprot:FA26E_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:FA26E_HUMAN
pepcoil	swissprot:FA26E_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:FA26E_HUMAN
pepdigest	swissprot:FA26E_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:FA26E_HUMAN
pepinfo	swissprot:FA26E_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:FA26E_HUMAN
pepnet	swissprot:FA26E_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:FA26E_HUMAN
pepstats	swissprot:FA26E_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:FA26E_HUMAN
pepwheel	swissprot:FA26E_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:FA26E_HUMAN
pepwindow	swissprot:FA26E_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:FA26E_HUMAN
sigcleave	swissprot:FA26E_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:FA26E_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S38A2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96QD8-1; Sequence=Displayed; Name=2; IsoId=Q96QD8-2; Sequence=VSP_029553, VSP_029554; 
# AltName	S38A2_HUMAN	Amino acid transporter A2
# AltName	S38A2_HUMAN	Protein 40-9-1
# AltName	S38A2_HUMAN	Solute carrier family 38 member 2
# AltName	S38A2_HUMAN	System A amino acid transporter 2
# AltName	S38A2_HUMAN	System A transporter 1
# AltName	S38A2_HUMAN	System N amino acid transporter 2
# BIOPHYSICOCHEMICAL PROPERTIES	Kinetic parameters	 KM=0.39 mM for 2-methylamino-isobutyric acid (MeAIB) (at pH 8.0); 
# BioGrid	119943	26
# CCDS	CCDS76551	-. [Q96QD8-2]
# CCDS	CCDS8749	-. [Q96QD8-1]
# ChiTaRS	SLC38A2	human
# ENZYME REGULATION	Inhibited by N-methyl-D-glucamine and probably choline. {ECO:0000269|PubMed	10930503}. 
# Ensembl	ENST00000256689	ENSP00000256689; ENSG00000134294. [Q96QD8-1]
# Ensembl	ENST00000612232	ENSP00000482873; ENSG00000134294. [Q96QD8-2]
# ExpressionAtlas	Q96QD8	baseline and differential
# FUNCTION	S38A2_HUMAN	Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1 1. May function in the transport of amino acids at the blood- brain barrier and in the supply of maternal nutrients to the fetus through the placenta. {ECO 0000269|PubMed 10930503, ECO 0000269|PubMed 15922329}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0005903	brush border; IEA:Ensembl.
# GO_component	GO:0030424	axon; IEA:Ensembl.
# GO_component	GO:0030425	dendrite; IEA:Ensembl.
# GO_component	GO:0042383	sarcolemma; IEA:Ensembl.
# GO_component	GO:0043025	neuronal cell body; IEA:Ensembl.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_process	GO:0003333	amino acid transmembrane transport; IBA:GO_Central.
# GO_process	GO:0006814	sodium ion transport; IEA:UniProtKB-KW.
# GO_process	GO:0006865	amino acid transport; TAS:Reactome.
# GO_process	GO:0007565	female pregnancy; IEA:Ensembl.
# GO_process	GO:0014047	glutamate secretion; TAS:Reactome.
# GO_process	GO:0021987	cerebral cortex development; IEA:Ensembl.
# GO_process	GO:0031460	glycine betaine transport; IEA:Ensembl.
# GO_process	GO:0032328	alanine transport; IEA:Ensembl.
# GO_process	GO:0034198	cellular response to amino acid starvation; IEA:Ensembl.
# GO_process	GO:0071260	cellular response to mechanical stimulus; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q96QD8	HS
# HGNC	HGNC:13448	SLC38A2
# INDUCTION	S38A2_HUMAN	Up-regulated upon hypertonic conditions and amino acid deprivation. {ECO 0000269|PubMed 14623874, ECO 0000269|PubMed 15922329, ECO 0000269|PubMed 16621798}. 
# INTERACTION	S38A2_HUMAN	Q99942 RNF5; NbExp=3; IntAct=EBI-723083, EBI-348482; 
# IntAct	Q96QD8	25
# InterPro	IPR013057	AA_transpt_TM
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04724	Glutamatergic synapse
# KEGG_Pathway	ko04727	GABAergic synapse
# KEGG_Pathway	ko04974	Protein digestion and absorption
# MIM	605180	gene
# MISCELLANEOUS	S38A2_HUMAN	Depletion of SCL38A2 by siRNA prevents the recovery of cells from hypertonic stress. 
# Organism	S38A2_HUMAN	Homo sapiens (Human)
# PTM	S38A2_HUMAN	Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2. {ECO 0000250}. 
# Pfam	PF01490	Aa_trans
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-210500	Glutamate Neurotransmitter Release Cycle
# Reactome	R-HSA-352230	Amino acid transport across the plasma membrane
# RecName	S38A2_HUMAN	Sodium-coupled neutral amino acid transporter 2
# RefSeq	NP_001294865	NM_001307936.1. [Q96QD8-2]
# RefSeq	NP_061849	NM_018976.4. [Q96QD8-1]
# SEQUENCE CAUTION	Sequence=BAD18765.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the amino acid/polyamine transporter 2 family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S38A2_HUMAN	Cell membrane {ECO 0000269|PubMed 15561425, ECO 0000269|PubMed 16616430}; Multi-pass membrane protein {ECO 0000269|PubMed 15561425, ECO 0000269|PubMed 16616430}. Note=Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (By similarity). Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal. {ECO 0000250}. 
# TCDB	2.A.18.6	the amino acid/auxin permease (aaap) family
# TISSUE SPECIFICITY	S38A2_HUMAN	Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level). {ECO 0000269|PubMed 10930503, ECO 0000269|PubMed 15561425, ECO 0000269|PubMed 16616430}. 
# UCSC	uc001rpg	human. [Q96QD8-1]
# eggNOG	COG0814	LUCA
# eggNOG	KOG1305	Eukaryota
BLAST	swissprot:S38A2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S38A2_HUMAN
COXPRESdb	54407	http://coxpresdb.jp/data/gene/54407.shtml
CleanEx	HS_SAT2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SAT2
CleanEx	HS_SLC38A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC38A2
DOI	10.1016/S0005-2736(00)00252-2	http://dx.doi.org/10.1016/S0005-2736(00)00252-2
DOI	10.1016/j.febslet.2005.05.002	http://dx.doi.org/10.1016/j.febslet.2005.05.002
DOI	10.1016/j.neuroscience.2004.09.023	http://dx.doi.org/10.1016/j.neuroscience.2004.09.023
DOI	10.1016/j.neuroscience.2006.02.042	http://dx.doi.org/10.1016/j.neuroscience.2006.02.042
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1074/jbc.M310483200	http://dx.doi.org/10.1074/jbc.M310483200
DOI	10.1074/jbc.M600341200	http://dx.doi.org/10.1074/jbc.M600341200
DOI	10.1093/dnares/7.1.65	http://dx.doi.org/10.1093/dnares/7.1.65
DOI	10.1093/dnares/9.3.99	http://dx.doi.org/10.1093/dnares/9.3.99
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AB037803	http://www.ebi.ac.uk/ena/data/view/AB037803
EMBL	AF259799	http://www.ebi.ac.uk/ena/data/view/AF259799
EMBL	AF298897	http://www.ebi.ac.uk/ena/data/view/AF298897
EMBL	AJ344099	http://www.ebi.ac.uk/ena/data/view/AJ344099
EMBL	AK001700	http://www.ebi.ac.uk/ena/data/view/AK001700
EMBL	AK172784	http://www.ebi.ac.uk/ena/data/view/AK172784
EMBL	BC040342	http://www.ebi.ac.uk/ena/data/view/BC040342
EMBL	CH471111	http://www.ebi.ac.uk/ena/data/view/CH471111
EMBL	CH471111	http://www.ebi.ac.uk/ena/data/view/CH471111
EMBL	CR457267	http://www.ebi.ac.uk/ena/data/view/CR457267
Ensembl	ENST00000256689	http://www.ensembl.org/id/ENST00000256689
Ensembl	ENST00000612232	http://www.ensembl.org/id/ENST00000612232
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005903	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005903
GO_component	GO:0030424	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030424
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0042383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042383
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_process	GO:0003333	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003333
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GO_process	GO:0007565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007565
GO_process	GO:0014047	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014047
GO_process	GO:0021987	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021987
GO_process	GO:0031460	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031460
GO_process	GO:0032328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032328
GO_process	GO:0034198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034198
GO_process	GO:0071260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071260
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC38A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC38A2
GeneID	54407	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54407
GeneTree	ENSGT00760000119147	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119147
HGNC	HGNC:13448	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13448
HOGENOM	HOG000013088	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000013088&db=HOGENOM6
HOVERGEN	HBG059571	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG059571&db=HOVERGEN
HPA	HPA035180	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035180
InParanoid	Q96QD8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96QD8
IntAct	Q96QD8	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96QD8*
InterPro	IPR013057	http://www.ebi.ac.uk/interpro/entry/IPR013057
Jabion	54407	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=54407
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:54407	http://www.genome.jp/dbget-bin/www_bget?hsa:54407
KEGG_Orthology	KO:K14207	http://www.genome.jp/dbget-bin/www_bget?KO:K14207
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
KEGG_Pathway	ko04974	http://www.genome.jp/kegg-bin/show_pathway?ko04974
MIM	605180	http://www.ncbi.nlm.nih.gov/omim/605180
MINT	MINT-1398587	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1398587
OMA	ITHLLCA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ITHLLCA
OrthoDB	EOG091G0GP8	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0GP8
PSORT	swissprot:S38A2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S38A2_HUMAN
PSORT-B	swissprot:S38A2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S38A2_HUMAN
PSORT2	swissprot:S38A2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S38A2_HUMAN
Pfam	PF01490	http://pfam.xfam.org/family/PF01490
PharmGKB	PA37773	http://www.pharmgkb.org/do/serve?objId=PA37773&objCls=Gene
Phobius	swissprot:S38A2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S38A2_HUMAN
PhylomeDB	Q96QD8	http://phylomedb.org/?seqid=Q96QD8
ProteinModelPortal	Q96QD8	http://www.proteinmodelportal.org/query/uniprot/Q96QD8
PubMed	10718198	http://www.ncbi.nlm.nih.gov/pubmed/10718198
PubMed	10930503	http://www.ncbi.nlm.nih.gov/pubmed/10930503
PubMed	12168954	http://www.ncbi.nlm.nih.gov/pubmed/12168954
PubMed	14623874	http://www.ncbi.nlm.nih.gov/pubmed/14623874
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15561425	http://www.ncbi.nlm.nih.gov/pubmed/15561425
PubMed	15922329	http://www.ncbi.nlm.nih.gov/pubmed/15922329
PubMed	16616430	http://www.ncbi.nlm.nih.gov/pubmed/16616430
PubMed	16621798	http://www.ncbi.nlm.nih.gov/pubmed/16621798
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
Reactome	R-HSA-210500	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-210500
Reactome	R-HSA-352230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-352230
RefSeq	NP_001294865	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001294865
RefSeq	NP_061849	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061849
STRING	9606.ENSP00000256689	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000256689&targetmode=cogs
TCDB	2.A.18.6	http://www.tcdb.org/search/result.php?tc=2.A.18.6
UCSC	uc001rpg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001rpg&org=rat
UniGene	Hs.221847	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.221847
UniProtKB	S38A2_HUMAN	http://www.uniprot.org/uniprot/S38A2_HUMAN
UniProtKB-AC	Q96QD8	http://www.uniprot.org/uniprot/Q96QD8
charge	swissprot:S38A2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S38A2_HUMAN
eggNOG	COG0814	http://eggnogapi.embl.de/nog_data/html/tree/COG0814
eggNOG	KOG1305	http://eggnogapi.embl.de/nog_data/html/tree/KOG1305
epestfind	swissprot:S38A2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S38A2_HUMAN
garnier	swissprot:S38A2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S38A2_HUMAN
helixturnhelix	swissprot:S38A2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S38A2_HUMAN
hmoment	swissprot:S38A2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S38A2_HUMAN
iep	swissprot:S38A2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S38A2_HUMAN
inforesidue	swissprot:S38A2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S38A2_HUMAN
neXtProt	NX_Q96QD8	http://www.nextprot.org/db/entry/NX_Q96QD8
octanol	swissprot:S38A2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S38A2_HUMAN
pepcoil	swissprot:S38A2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S38A2_HUMAN
pepdigest	swissprot:S38A2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S38A2_HUMAN
pepinfo	swissprot:S38A2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S38A2_HUMAN
pepnet	swissprot:S38A2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S38A2_HUMAN
pepstats	swissprot:S38A2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S38A2_HUMAN
pepwheel	swissprot:S38A2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S38A2_HUMAN
pepwindow	swissprot:S38A2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S38A2_HUMAN
sigcleave	swissprot:S38A2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S38A2_HUMAN
## Database	ID	URL or Descriptions
# AltName	NMDE4_HUMAN	EB11
# AltName	NMDE4_HUMAN	Glutamate [NMDA] receptor subunit epsilon-4
# AltName	NMDE4_HUMAN	N-methyl D-aspartate receptor subtype 2D
# BioGrid	109163	3
# DrugBank	DB00289	Atomoxetine
# DrugBank	DB00312	Pentobarbital
# DrugBank	DB00418	Secobarbital
# DrugBank	DB00454	Pethidine
# DrugBank	DB00659	Acamprosate
# DrugBank	DB00996	Gabapentin
# DrugBank	DB01173	Orphenadrine
# DrugBank	DB01174	Phenobarbital
# DrugBank	DB04896	Milnacipran
# DrugBank	DB06151	Acetylcysteine
# DrugBank	DB06738	Ketobemidone
# Ensembl	ENST00000263269	ENSP00000263269; ENSG00000105464
# FUNCTION	NMDE4_HUMAN	NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. 
# GO_component	GO:0005622	intracellular; IEA:GOC.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0017146	NMDA selective glutamate receptor complex; IBA:GO_Central.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0004972	NMDA glutamate receptor activity; IBA:GO_Central.
# GO_function	GO:0005088	Ras guanyl-nucleotide exchange factor activity; TAS:Reactome.
# GO_function	GO:0005234	extracellular-glutamate-gated ion channel activity; IEA:InterPro.
# GO_process	GO:0000165	MAPK cascade; TAS:Reactome.
# GO_process	GO:0001964	startle response; IEA:Ensembl.
# GO_process	GO:0007165	signal transduction; NAS:ProtInc.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:Reactome.
# GO_process	GO:0008344	adult locomotory behavior; IEA:Ensembl.
# GO_process	GO:0051930	regulation of sensory perception of pain; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005622	intracellular
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# Genevisible	O15399	HS
# HGNC	HGNC:4588	GRIN2D
# INTERACTION	NMDE4_HUMAN	Q62936 Dlg3 (xeno); NbExp=2; IntAct=EBI-1754030, EBI-349596; 
# IntAct	O15399	4
# InterPro	IPR001320	Iontro_rcpt
# InterPro	IPR001508	Iono_rcpt_met
# InterPro	IPR001828	ANF_lig-bd_rcpt
# InterPro	IPR019594	Glu/Gly-bd
# InterPro	IPR028082	Peripla_BP_I
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04713	Circadian entrainment
# KEGG_Pathway	ko04720	Long-term potentiation
# KEGG_Pathway	ko04724	Glutamatergic synapse
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05014	Amyotrophic lateral sclerosis (ALS)
# KEGG_Pathway	ko05030	Cocaine addiction
# KEGG_Pathway	ko05031	Amphetamine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# KEGG_Pathway	ko05034	Alcoholism
# MIM	602717	gene
# Organism	NMDE4_HUMAN	Homo sapiens (Human)
# PRINTS	PR00177	NMDARECEPTOR
# Pfam	PF00060	Lig_chan
# Pfam	PF01094	ANF_receptor
# Pfam	PF10613	Lig_chan-Glu_bd
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-438066	Unblocking of NMDA receptor, glutamate binding and activation
# Reactome	R-HSA-442729	CREB phosphorylation through the activation of CaMKII
# Reactome	R-HSA-442982	Ras activation uopn Ca2+ infux through NMDA receptor
# Reactome	R-HSA-5673001	RAF/MAP kinase cascade
# Reactome	R-HSA-6794361	Interactions of neurexins and neuroligins at synapses
# Reactome	R-HSA-8849932	SALM protein interactions at the synapses
# RecName	NMDE4_HUMAN	Glutamate receptor ionotropic, NMDA 2D
# RefSeq	NP_000827	NM_000836.2
# RefSeq	XP_011525174	XM_011526872.1
# SIMILARITY	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2D/GRIN2D subfamily. {ECO	0000305}.
# SMART	SM00079	PBPe
# SMART	SM00918	Lig_chan-Glu_bd
# SUBCELLULAR LOCATION	NMDE4_HUMAN	Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Interacts with PDZ domains of PATJ and DLG4 (By similarity). Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). {ECO	0000250}. 
# SUPFAM	SSF53822	SSF53822
# UCSC	uc002pjc	human
# eggNOG	ENOG410XNUR	LUCA
# eggNOG	KOG1053	Eukaryota
BLAST	swissprot:NMDE4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NMDE4_HUMAN
BioCyc	ZFISH:ENSG00000105464-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000105464-MONOMER
COXPRESdb	2906	http://coxpresdb.jp/data/gene/2906.shtml
CleanEx	HS_GRIN2D	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GRIN2D
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DrugBank	DB00289	http://www.drugbank.ca/drugs/DB00289
DrugBank	DB00312	http://www.drugbank.ca/drugs/DB00312
DrugBank	DB00418	http://www.drugbank.ca/drugs/DB00418
DrugBank	DB00454	http://www.drugbank.ca/drugs/DB00454
DrugBank	DB00659	http://www.drugbank.ca/drugs/DB00659
DrugBank	DB00996	http://www.drugbank.ca/drugs/DB00996
DrugBank	DB01173	http://www.drugbank.ca/drugs/DB01173
DrugBank	DB01174	http://www.drugbank.ca/drugs/DB01174
DrugBank	DB04896	http://www.drugbank.ca/drugs/DB04896
DrugBank	DB06151	http://www.drugbank.ca/drugs/DB06151
DrugBank	DB06738	http://www.drugbank.ca/drugs/DB06738
EMBL	AC008403	http://www.ebi.ac.uk/ena/data/view/AC008403
EMBL	AC011527	http://www.ebi.ac.uk/ena/data/view/AC011527
EMBL	U77783	http://www.ebi.ac.uk/ena/data/view/U77783
Ensembl	ENST00000263269	http://www.ensembl.org/id/ENST00000263269
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0017146	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017146
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0004972	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004972
GO_function	GO:0005088	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005088
GO_function	GO:0005234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005234
GO_process	GO:0000165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000165
GO_process	GO:0001964	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001964
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0008344	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008344
GO_process	GO:0051930	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051930
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	GRIN2D	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GRIN2D
GeneID	2906	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2906
GeneTree	ENSGT00760000119186	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119186
H-InvDB	HIX0040164	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0040164
HGNC	HGNC:4588	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4588
HOGENOM	HOG000113803	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000113803&db=HOGENOM6
HOVERGEN	HBG052637	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052637&db=HOVERGEN
InParanoid	O15399	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O15399
IntAct	O15399	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O15399*
InterPro	IPR001320	http://www.ebi.ac.uk/interpro/entry/IPR001320
InterPro	IPR001508	http://www.ebi.ac.uk/interpro/entry/IPR001508
InterPro	IPR001828	http://www.ebi.ac.uk/interpro/entry/IPR001828
InterPro	IPR019594	http://www.ebi.ac.uk/interpro/entry/IPR019594
InterPro	IPR028082	http://www.ebi.ac.uk/interpro/entry/IPR028082
Jabion	2906	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2906
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:2906	http://www.genome.jp/dbget-bin/www_bget?hsa:2906
KEGG_Orthology	KO:K05212	http://www.genome.jp/dbget-bin/www_bget?KO:K05212
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04713	http://www.genome.jp/kegg-bin/show_pathway?ko04713
KEGG_Pathway	ko04720	http://www.genome.jp/kegg-bin/show_pathway?ko04720
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05014	http://www.genome.jp/kegg-bin/show_pathway?ko05014
KEGG_Pathway	ko05030	http://www.genome.jp/kegg-bin/show_pathway?ko05030
KEGG_Pathway	ko05031	http://www.genome.jp/kegg-bin/show_pathway?ko05031
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
KEGG_Pathway	ko05034	http://www.genome.jp/kegg-bin/show_pathway?ko05034
MIM	602717	http://www.ncbi.nlm.nih.gov/omim/602717
MINT	MINT-130143	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-130143
OMA	WDYLPPR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WDYLPPR
OrthoDB	EOG091G09KH	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G09KH
PRINTS	PR00177	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00177
PSORT	swissprot:NMDE4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NMDE4_HUMAN
PSORT-B	swissprot:NMDE4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NMDE4_HUMAN
PSORT2	swissprot:NMDE4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NMDE4_HUMAN
Pfam	PF00060	http://pfam.xfam.org/family/PF00060
Pfam	PF01094	http://pfam.xfam.org/family/PF01094
Pfam	PF10613	http://pfam.xfam.org/family/PF10613
PharmGKB	PA28982	http://www.pharmgkb.org/do/serve?objId=PA28982&objCls=Gene
Phobius	swissprot:NMDE4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NMDE4_HUMAN
PhylomeDB	O15399	http://phylomedb.org/?seqid=O15399
ProteinModelPortal	O15399	http://www.proteinmodelportal.org/query/uniprot/O15399
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	9489750	http://www.ncbi.nlm.nih.gov/pubmed/9489750
Reactome	R-HSA-438066	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-438066
Reactome	R-HSA-442729	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442729
Reactome	R-HSA-442982	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442982
Reactome	R-HSA-5673001	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5673001
Reactome	R-HSA-6794361	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6794361
Reactome	R-HSA-8849932	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8849932
RefSeq	NP_000827	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000827
RefSeq	XP_011525174	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011525174
SMART	SM00079	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00079
SMART	SM00918	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00918
STRING	9606.ENSP00000263269	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000263269&targetmode=cogs
SUPFAM	SSF53822	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822
UCSC	uc002pjc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002pjc&org=rat
UniGene	Hs.445015	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.445015
UniProtKB	NMDE4_HUMAN	http://www.uniprot.org/uniprot/NMDE4_HUMAN
UniProtKB-AC	O15399	http://www.uniprot.org/uniprot/O15399
charge	swissprot:NMDE4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NMDE4_HUMAN
eggNOG	ENOG410XNUR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNUR
eggNOG	KOG1053	http://eggnogapi.embl.de/nog_data/html/tree/KOG1053
epestfind	swissprot:NMDE4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NMDE4_HUMAN
garnier	swissprot:NMDE4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NMDE4_HUMAN
helixturnhelix	swissprot:NMDE4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NMDE4_HUMAN
hmoment	swissprot:NMDE4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NMDE4_HUMAN
iep	swissprot:NMDE4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NMDE4_HUMAN
inforesidue	swissprot:NMDE4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NMDE4_HUMAN
neXtProt	NX_O15399	http://www.nextprot.org/db/entry/NX_O15399
octanol	swissprot:NMDE4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NMDE4_HUMAN
pepcoil	swissprot:NMDE4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NMDE4_HUMAN
pepdigest	swissprot:NMDE4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NMDE4_HUMAN
pepinfo	swissprot:NMDE4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NMDE4_HUMAN
pepnet	swissprot:NMDE4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NMDE4_HUMAN
pepstats	swissprot:NMDE4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NMDE4_HUMAN
pepwheel	swissprot:NMDE4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NMDE4_HUMAN
pepwindow	swissprot:NMDE4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NMDE4_HUMAN
sigcleave	swissprot:NMDE4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NMDE4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GLRB_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P48167-1; Sequence=Displayed; Name=2; IsoId=P48167-2; Sequence=VSP_045466, VSP_045467; Note=No experimental confirmation available.; 
# AltName	GLRB_HUMAN	Glycine receptor 58 kDa subunit
# BioGrid	109005	12
# CCDS	CCDS3796	-. [P48167-1]
# CCDS	CCDS54813	-. [P48167-2]
# DISEASE	GLRB_HUMAN	Hyperekplexia 2 (HKPX2) [MIM 614619]  A neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli. {ECO 0000269|PubMed 11929858, ECO 0000269|PubMed 21391991, ECO 0000269|PubMed 23238346}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00145	Glycine
# DrugBank	DB00228	Enflurane
# DrugBank	DB00431	Lindane
# Ensembl	ENST00000264428	ENSP00000264428; ENSG00000109738. [P48167-1]
# Ensembl	ENST00000509282	ENSP00000427186; ENSG00000109738. [P48167-1]
# Ensembl	ENST00000541722	ENSP00000441873; ENSG00000109738. [P48167-2]
# ExpressionAtlas	P48167	baseline and differential
# FUNCTION	GLRB_HUMAN	Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed 8717357, PubMed 15302677, PubMed 16144831, PubMed 22715885, PubMed 25445488, PubMed 11929858, PubMed 23238346). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (PubMed 8717357). Plays an important role in the down-regulation of neuronal excitability (PubMed 11929858, PubMed 23238346). Contributes to the generation of inhibitory postsynaptic currents (PubMed 25445488). {ECO 0000269|PubMed 11929858, ECO 0000269|PubMed 15302677, ECO 0000269|PubMed 16144831, ECO 0000269|PubMed 22715885, ECO 0000269|PubMed 23238346, ECO 0000269|PubMed 25445488, ECO 0000269|PubMed 8717357}. 
# GO_component	GO:0005737	cytoplasm; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016935	glycine-gated chloride channel complex; IDA:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030425	dendrite; IEA:UniProtKB-SubCell.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0098982	GABA-ergic synapse; IEA:Ensembl.
# GO_function	GO:0008144	drug binding; IEA:Ensembl.
# GO_function	GO:0016594	glycine binding; IEA:Ensembl.
# GO_function	GO:0016933	extracellular-glycine-gated ion channel activity; IMP:UniProtKB.
# GO_function	GO:0016934	extracellular-glycine-gated chloride channel activity; IEA:Ensembl.
# GO_process	GO:0001964	startle response; IMP:UniProtKB.
# GO_process	GO:0006811	ion transport; IDA:UniProtKB.
# GO_process	GO:0007218	neuropeptide signaling pathway; IDA:UniProtKB.
# GO_process	GO:0007268	chemical synaptic transmission; IMP:UniProtKB.
# GO_process	GO:0007340	acrosome reaction; IEA:Ensembl.
# GO_process	GO:0007399	nervous system development; IMP:UniProtKB.
# GO_process	GO:0007601	visual perception; IEA:Ensembl.
# GO_process	GO:0007628	adult walking behavior; IEA:Ensembl.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0042391	regulation of membrane potential; IEA:Ensembl.
# GO_process	GO:0043200	response to amino acid; IBA:GO_Central.
# GO_process	GO:0051291	protein heterooligomerization; IEA:Ensembl.
# GO_process	GO:0060012	synaptic transmission, glycinergic; IBA:GO_Central.
# GO_process	GO:0060013	righting reflex; IEA:Ensembl.
# GO_process	GO:0097112	gamma-aminobutyric acid receptor clustering; IEA:Ensembl.
# GO_process	GO:1902476	chloride transmembrane transport; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# GOslim_process	GO:0061024	membrane organization
# Gene3D	2.70.170.10	-; 1.
# Genevisible	P48167	HS
# HGNC	HGNC:4329	GLRB
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR008060	Glycine_rcpt_B
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00769	[Nervous system disease] Hyperekplexia
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# MIM	138492	gene
# MIM	614619	phenotype
# Organism	GLRB_HUMAN	Homo sapiens (Human)
# Orphanet	3197	Hereditary hyperekplexia
# PANTHER	PTHR18945	PTHR18945; 2
# PANTHER	PTHR18945:SF29	PTHR18945:SF29; 2
# PIR	G02031	G02031
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR01677	GLYRBETA
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-975298	Ligand-gated ion channel transport
# RecName	GLRB_HUMAN	Glycine receptor subunit beta
# RefSeq	NP_000815	NM_000824.4. [P48167-1]
# RefSeq	NP_001159532	NM_001166060.1. [P48167-1]
# RefSeq	NP_001159533	NM_001166061.1. [P48167-2]
# RefSeq	XP_016863524	XM_017008035.1. [P48167-2]
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRB sub- subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	GLRB_HUMAN	Cell junction, synapse, postsynaptic cell membrane {ECO 0000250|UniProtKB P48168}; Multi-pass membrane protein {ECO 0000250|UniProtKB P48167}. Cell junction, synapse {ECO 0000250|UniProtKB P48168}. Cell projection, dendrite {ECO 0000250|UniProtKB P48168}. Cell membrane {ECO 0000269|PubMed 11929858, ECO 0000269|PubMed 12684523, ECO 0000269|PubMed 15302677, ECO 0000269|PubMed 16144831, ECO 0000269|PubMed 22715885, ECO 0000269|PubMed 22973015, ECO 0000269|PubMed 23238346, ECO 0000269|PubMed 25445488, ECO 0000269|PubMed 8717357}; Multi-pass membrane protein {ECO 0000250|UniProtKB P23415}. Cytoplasm {ECO 0000269|PubMed 12684523}. Note=Retained in the cytoplasm upon heterologous expression by itself. Coexpression with GPHN promotes expression at the cell membrane (PubMed 12684523). Coexpression with GLRA1, GLRA2 or GLRA3 promotes expression at the cell membrane. {ECO 0000250|UniProtKB P20781, ECO 0000269|PubMed 12684523}. 
# SUBUNIT	GLRB_HUMAN	Heteropentamer composed of GLRB and GLRA1 (PubMed 8717357, PubMed 14551753, PubMed 22973015, PubMed 22715885, PubMed 25445488, PubMed 11929858, PubMed 23238346). Heteropentamer composed of GLRB and GLRA2 (PubMed 15302677, PubMed 16144831, PubMed 25445488). Heteropentamer composed of GLRB and GLRA3 (PubMed 25445488). Heteropentamer composed of two GLRA1 and three GLRB subunits (PubMed 22715885). Heteropentamer composed of three GLRA1 and two GLRB subunits (PubMed 22973015). Interacts with GPHN (PubMed 12684523,PubMed 26613940). {ECO 0000269|PubMed 11929858, ECO 0000269|PubMed 12684523, ECO 0000269|PubMed 14551753, ECO 0000269|PubMed 15302677, ECO 0000269|PubMed 16144831, ECO 0000269|PubMed 22715885, ECO 0000269|PubMed 22973015, ECO 0000269|PubMed 23238346, ECO 0000269|PubMed 25445488, ECO 0000269|PubMed 26613940, ECO 0000269|PubMed 8717357}. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TCDB	1.A.9.3	the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family
# TIGRFAMs	TIGR00860	LIC
# UCSC	uc003ipj	human. [P48167-1]
# eggNOG	ENOG410XP43	LUCA
# eggNOG	KOG3644	Eukaryota
BLAST	swissprot:GLRB_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GLRB_HUMAN
BioCyc	ZFISH:ENSG00000109738-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000109738-MONOMER
COXPRESdb	2743	http://coxpresdb.jp/data/gene/2743.shtml
CleanEx	HS_GLRB	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GLRB
DOI	10.1006/geno.1998.5324	http://dx.doi.org/10.1006/geno.1998.5324
DOI	10.1007/s00249-003-0286-y	http://dx.doi.org/10.1007/s00249-003-0286-y
DOI	10.1016/0169-328X(95)00215-E	http://dx.doi.org/10.1016/0169-328X(95)00215-E
DOI	10.1016/j.nbd.2012.12.001	http://dx.doi.org/10.1016/j.nbd.2012.12.001
DOI	10.1016/j.neuropharm.2014.10.026	http://dx.doi.org/10.1016/j.neuropharm.2014.10.026
DOI	10.1016/j.ygeno.2003.09.023	http://dx.doi.org/10.1016/j.ygeno.2003.09.023
DOI	10.1021/bi300063m	http://dx.doi.org/10.1021/bi300063m
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.bjp.0705875	http://dx.doi.org/10.1038/sj.bjp.0705875
DOI	10.1074/jbc.M301070200	http://dx.doi.org/10.1074/jbc.M301070200
DOI	10.1074/jbc.M508303200	http://dx.doi.org/10.1074/jbc.M508303200
DOI	10.1093/hmg/11.7.853	http://dx.doi.org/10.1093/hmg/11.7.853
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1399-0004.2011.01661.x	http://dx.doi.org/10.1111/j.1399-0004.2011.01661.x
DOI	10.1523/JNEUROSCI.2050-12.2012	http://dx.doi.org/10.1523/JNEUROSCI.2050-12.2012
DOI	10.15252/emmm.201505323	http://dx.doi.org/10.15252/emmm.201505323
DrugBank	DB00145	http://www.drugbank.ca/drugs/DB00145
DrugBank	DB00228	http://www.drugbank.ca/drugs/DB00228
DrugBank	DB00431	http://www.drugbank.ca/drugs/DB00431
EMBL	AC079403	http://www.ebi.ac.uk/ena/data/view/AC079403
EMBL	AF094754	http://www.ebi.ac.uk/ena/data/view/AF094754
EMBL	AF094755	http://www.ebi.ac.uk/ena/data/view/AF094755
EMBL	AK290617	http://www.ebi.ac.uk/ena/data/view/AK290617
EMBL	BC032635	http://www.ebi.ac.uk/ena/data/view/BC032635
EMBL	CD013911	http://www.ebi.ac.uk/ena/data/view/CD013911
EMBL	CH471056	http://www.ebi.ac.uk/ena/data/view/CH471056
EMBL	CH471056	http://www.ebi.ac.uk/ena/data/view/CH471056
EMBL	U33267	http://www.ebi.ac.uk/ena/data/view/U33267
Ensembl	ENST00000264428	http://www.ensembl.org/id/ENST00000264428
Ensembl	ENST00000509282	http://www.ensembl.org/id/ENST00000509282
Ensembl	ENST00000541722	http://www.ensembl.org/id/ENST00000541722
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016935	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016935
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_component	GO:0098982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098982
GO_function	GO:0008144	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008144
GO_function	GO:0016594	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016594
GO_function	GO:0016933	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016933
GO_function	GO:0016934	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016934
GO_process	GO:0001964	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001964
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0007218	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007218
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007340	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007340
GO_process	GO:0007399	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007399
GO_process	GO:0007601	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007601
GO_process	GO:0007628	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007628
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0043200	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043200
GO_process	GO:0051291	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051291
GO_process	GO:0060012	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060012
GO_process	GO:0060013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060013
GO_process	GO:0097112	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097112
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	GLRB	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GLRB
GeneID	2743	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2743
GeneTree	ENSGT00760000118821	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118821
HGNC	HGNC:4329	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4329
HOGENOM	HOG000231336	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231336&db=HOGENOM6
HOVERGEN	HBG051707	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051707&db=HOVERGEN
HPA	HPA052363	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA052363
InParanoid	P48167	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P48167
IntAct	P48167	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P48167*
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR008060	http://www.ebi.ac.uk/interpro/entry/IPR008060
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
Jabion	2743	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2743
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00769	http://www.genome.jp/dbget-bin/www_bget?H00769
KEGG_Gene	hsa:2743	http://www.genome.jp/dbget-bin/www_bget?hsa:2743
KEGG_Orthology	KO:K05196	http://www.genome.jp/dbget-bin/www_bget?KO:K05196
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
MIM	138492	http://www.ncbi.nlm.nih.gov/omim/138492
MIM	614619	http://www.ncbi.nlm.nih.gov/omim/614619
OMA	PRLKLPN	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PRLKLPN
Orphanet	3197	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=3197
OrthoDB	EOG091G0805	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0805
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PANTHER	PTHR18945:SF29	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945:SF29
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR01677	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01677
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:GLRB_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GLRB_HUMAN
PSORT-B	swissprot:GLRB_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GLRB_HUMAN
PSORT2	swissprot:GLRB_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GLRB_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA28730	http://www.pharmgkb.org/do/serve?objId=PA28730&objCls=Gene
Phobius	swissprot:GLRB_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GLRB_HUMAN
PhylomeDB	P48167	http://phylomedb.org/?seqid=P48167
ProteinModelPortal	P48167	http://www.proteinmodelportal.org/query/uniprot/P48167
PubMed	11929858	http://www.ncbi.nlm.nih.gov/pubmed/11929858
PubMed	12684523	http://www.ncbi.nlm.nih.gov/pubmed/12684523
PubMed	14551753	http://www.ncbi.nlm.nih.gov/pubmed/14551753
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15028279	http://www.ncbi.nlm.nih.gov/pubmed/15028279
PubMed	15302677	http://www.ncbi.nlm.nih.gov/pubmed/15302677
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	16144831	http://www.ncbi.nlm.nih.gov/pubmed/16144831
PubMed	21391991	http://www.ncbi.nlm.nih.gov/pubmed/21391991
PubMed	22715885	http://www.ncbi.nlm.nih.gov/pubmed/22715885
PubMed	22973015	http://www.ncbi.nlm.nih.gov/pubmed/22973015
PubMed	23238346	http://www.ncbi.nlm.nih.gov/pubmed/23238346
PubMed	25445488	http://www.ncbi.nlm.nih.gov/pubmed/25445488
PubMed	26613940	http://www.ncbi.nlm.nih.gov/pubmed/26613940
PubMed	8717357	http://www.ncbi.nlm.nih.gov/pubmed/8717357
PubMed	9676428	http://www.ncbi.nlm.nih.gov/pubmed/9676428
Reactome	R-HSA-975298	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-975298
RefSeq	NP_000815	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000815
RefSeq	NP_001159532	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001159532
RefSeq	NP_001159533	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001159533
RefSeq	XP_016863524	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016863524
SMR	P48167	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P48167
STRING	9606.ENSP00000264428	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000264428&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TCDB	1.A.9.3	http://www.tcdb.org/search/result.php?tc=1.A.9.3
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc003ipj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ipj&org=rat
UniGene	Hs.32973	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.32973
UniProtKB	GLRB_HUMAN	http://www.uniprot.org/uniprot/GLRB_HUMAN
UniProtKB-AC	P48167	http://www.uniprot.org/uniprot/P48167
charge	swissprot:GLRB_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GLRB_HUMAN
eggNOG	ENOG410XP43	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XP43
eggNOG	KOG3644	http://eggnogapi.embl.de/nog_data/html/tree/KOG3644
epestfind	swissprot:GLRB_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GLRB_HUMAN
garnier	swissprot:GLRB_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GLRB_HUMAN
helixturnhelix	swissprot:GLRB_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLRB_HUMAN
hmoment	swissprot:GLRB_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GLRB_HUMAN
iep	swissprot:GLRB_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GLRB_HUMAN
inforesidue	swissprot:GLRB_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GLRB_HUMAN
neXtProt	NX_P48167	http://www.nextprot.org/db/entry/NX_P48167
octanol	swissprot:GLRB_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GLRB_HUMAN
pepcoil	swissprot:GLRB_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GLRB_HUMAN
pepdigest	swissprot:GLRB_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GLRB_HUMAN
pepinfo	swissprot:GLRB_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GLRB_HUMAN
pepnet	swissprot:GLRB_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GLRB_HUMAN
pepstats	swissprot:GLRB_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GLRB_HUMAN
pepwheel	swissprot:GLRB_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GLRB_HUMAN
pepwindow	swissprot:GLRB_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GLRB_HUMAN
sigcleave	swissprot:GLRB_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GLRB_HUMAN
## Database	ID	URL or Descriptions
# AltName	VA0D2_HUMAN	Vacuolar proton pump subunit d 2
# BioGrid	128858	18
# Ensembl	ENST00000285393	ENSP00000285393; ENSG00000147614
# ExpressionAtlas	Q8N8Y2	baseline and differential
# FUNCTION	VA0D2_HUMAN	Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity). {ECO 0000250}. 
# GO_component	GO:0005765	lysosomal membrane; IBA:GO_Central.
# GO_component	GO:0005769	early endosome; IBA:GO_Central.
# GO_component	GO:0010008	endosome membrane; TAS:Reactome.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016471	vacuolar proton-transporting V-type ATPase complex; IDA:UniProtKB.
# GO_component	GO:0030670	phagocytic vesicle membrane; TAS:Reactome.
# GO_component	GO:0033179	proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
# GO_component	GO:0033181	plasma membrane proton-transporting V-type ATPase complex; IBA:GO_Central.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism; IBA:GO_Central.
# GO_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
# GO_process	GO:0007034	vacuolar transport; IBA:GO_Central.
# GO_process	GO:0007035	vacuolar acidification; IBA:GO_Central.
# GO_process	GO:0008286	insulin receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0015991	ATP hydrolysis coupled proton transport; IEA:InterPro.
# GO_process	GO:0016241	regulation of macroautophagy; NAS:ParkinsonsUK-UCL.
# GO_process	GO:0033572	transferrin transport; TAS:Reactome.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0090383	phagosome acidification; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007034	vacuolar transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q8N8Y2	HS
# HGNC	HGNC:18266	ATP6V0D2
# IntAct	Q8N8Y2	9
# InterPro	IPR002843	ATPase_V0-cplx_csu/dsu
# InterPro	IPR016727	ATPase_V0-cplx_dsu
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04142	Lysosome
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04966	Collecting duct acid secretion
# KEGG_Pathway	ko05110	Vibrio cholerae infection
# KEGG_Pathway	ko05120	Epithelial cell signaling in Helicobacter pylori infection
# KEGG_Pathway	ko05152	Tuberculosis
# KEGG_Pathway	ko05203	Viral carcinogenesis
# KEGG_Pathway	ko05323	Rheumatoid arthritis
# Organism	VA0D2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11028	PTHR11028
# PIRSF	PIRSF018497	V-ATP_synth_D
# Pfam	PF01992	vATP-synt_AC39
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-1222556	ROS, RNS production in response to bacteria
# Reactome	R-HSA-77387	Insulin receptor recycling
# Reactome	R-HSA-917977	Transferrin endocytosis and recycling
# Reactome	R-HSA-983712	Ion channel transport
# RecName	VA0D2_HUMAN	V-type proton ATPase subunit d 2
# RefSeq	NP_689778	NM_152565.1
# SIMILARITY	Belongs to the V-ATPase V0D/AC39 subunit family. {ECO	0000305}.
# SUBUNIT	V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components	 a, c, c', c'' and d). 
# SUPFAM	SSF103486	SSF103486
# TISSUE SPECIFICITY	Kidney, osteoclast and lung. {ECO:0000269|PubMed	12384298}. 
# UCSC	uc003ydp	human
# eggNOG	COG1527	LUCA
# eggNOG	KOG2957	Eukaryota
BLAST	swissprot:VA0D2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VA0D2_HUMAN
BioCyc	MetaCyc:HS07458-MONOMER	http://biocyc.org/getid?id=MetaCyc:HS07458-MONOMER
BioCyc	ZFISH:HS07458-MONOMER	http://biocyc.org/getid?id=ZFISH:HS07458-MONOMER
COG	COG1527	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1527
COXPRESdb	245972	http://coxpresdb.jp/data/gene/245972.shtml
CleanEx	HS_ATP6V0D2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP6V0D2
DOI	10.1016/S0378-1119(02)00884-3	http://dx.doi.org/10.1016/S0378-1119(02)00884-3
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AK096027	http://www.ebi.ac.uk/ena/data/view/AK096027
EMBL	AY079172	http://www.ebi.ac.uk/ena/data/view/AY079172
EMBL	BC065207	http://www.ebi.ac.uk/ena/data/view/BC065207
Ensembl	ENST00000285393	http://www.ensembl.org/id/ENST00000285393
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005769	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005769
GO_component	GO:0010008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010008
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0016471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016471
GO_component	GO:0030670	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030670
GO_component	GO:0033179	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033179
GO_component	GO:0033181	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033181
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0008553	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008553
GO_function	GO:0046961	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046961
GO_process	GO:0007034	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007034
GO_process	GO:0007035	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007035
GO_process	GO:0008286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008286
GO_process	GO:0015991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015991
GO_process	GO:0016241	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016241
GO_process	GO:0033572	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033572
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0090383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090383
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007034	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007034
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ATP6V0D2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP6V0D2
GeneID	245972	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=245972
GeneTree	ENSGT00390000002200	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002200
HGNC	HGNC:18266	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18266
HOGENOM	HOG000199065	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000199065&db=HOGENOM6
HOVERGEN	HBG018065	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG018065&db=HOVERGEN
HPA	HPA055327	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA055327
HPA	HPA058496	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA058496
InParanoid	Q8N8Y2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8N8Y2
IntAct	Q8N8Y2	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8N8Y2*
InterPro	IPR002843	http://www.ebi.ac.uk/interpro/entry/IPR002843
InterPro	IPR016727	http://www.ebi.ac.uk/interpro/entry/IPR016727
Jabion	245972	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=245972
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:245972	http://www.genome.jp/dbget-bin/www_bget?hsa:245972
KEGG_Orthology	KO:K02146	http://www.genome.jp/dbget-bin/www_bget?KO:K02146
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04142	http://www.genome.jp/kegg-bin/show_pathway?ko04142
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04966	http://www.genome.jp/kegg-bin/show_pathway?ko04966
KEGG_Pathway	ko05110	http://www.genome.jp/kegg-bin/show_pathway?ko05110
KEGG_Pathway	ko05120	http://www.genome.jp/kegg-bin/show_pathway?ko05120
KEGG_Pathway	ko05152	http://www.genome.jp/kegg-bin/show_pathway?ko05152
KEGG_Pathway	ko05203	http://www.genome.jp/kegg-bin/show_pathway?ko05203
KEGG_Pathway	ko05323	http://www.genome.jp/kegg-bin/show_pathway?ko05323
OMA	DFEQMKR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DFEQMKR
OrthoDB	EOG091G09L5	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G09L5
PANTHER	PTHR11028	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11028
PSORT	swissprot:VA0D2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VA0D2_HUMAN
PSORT-B	swissprot:VA0D2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VA0D2_HUMAN
PSORT2	swissprot:VA0D2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VA0D2_HUMAN
Pfam	PF01992	http://pfam.xfam.org/family/PF01992
PharmGKB	PA38516	http://www.pharmgkb.org/do/serve?objId=PA38516&objCls=Gene
Phobius	swissprot:VA0D2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VA0D2_HUMAN
PhylomeDB	Q8N8Y2	http://phylomedb.org/?seqid=Q8N8Y2
ProteinModelPortal	Q8N8Y2	http://www.proteinmodelportal.org/query/uniprot/Q8N8Y2
PubMed	12384298	http://www.ncbi.nlm.nih.gov/pubmed/12384298
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-1222556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1222556
Reactome	R-HSA-77387	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-77387
Reactome	R-HSA-917977	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917977
Reactome	R-HSA-983712	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983712
RefSeq	NP_689778	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_689778
STRING	9606.ENSP00000285393	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000285393&targetmode=cogs
STRING	COG1527	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1527&targetmode=cogs
SUPFAM	SSF103486	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103486
UCSC	uc003ydp	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ydp&org=rat
UniGene	Hs.436360	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.436360
UniProtKB	VA0D2_HUMAN	http://www.uniprot.org/uniprot/VA0D2_HUMAN
UniProtKB-AC	Q8N8Y2	http://www.uniprot.org/uniprot/Q8N8Y2
charge	swissprot:VA0D2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VA0D2_HUMAN
eggNOG	COG1527	http://eggnogapi.embl.de/nog_data/html/tree/COG1527
eggNOG	KOG2957	http://eggnogapi.embl.de/nog_data/html/tree/KOG2957
epestfind	swissprot:VA0D2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VA0D2_HUMAN
garnier	swissprot:VA0D2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VA0D2_HUMAN
helixturnhelix	swissprot:VA0D2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VA0D2_HUMAN
hmoment	swissprot:VA0D2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VA0D2_HUMAN
iep	swissprot:VA0D2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VA0D2_HUMAN
inforesidue	swissprot:VA0D2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VA0D2_HUMAN
neXtProt	NX_Q8N8Y2	http://www.nextprot.org/db/entry/NX_Q8N8Y2
octanol	swissprot:VA0D2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VA0D2_HUMAN
pepcoil	swissprot:VA0D2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VA0D2_HUMAN
pepdigest	swissprot:VA0D2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VA0D2_HUMAN
pepinfo	swissprot:VA0D2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VA0D2_HUMAN
pepnet	swissprot:VA0D2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VA0D2_HUMAN
pepstats	swissprot:VA0D2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VA0D2_HUMAN
pepwheel	swissprot:VA0D2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VA0D2_HUMAN
pepwindow	swissprot:VA0D2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VA0D2_HUMAN
sigcleave	swissprot:VA0D2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VA0D2_HUMAN
## Database	ID	URL or Descriptions
# AltName	NMDE3_HUMAN	Glutamate [NMDA] receptor subunit epsilon-3
# AltName	NMDE3_HUMAN	N-methyl D-aspartate receptor subtype 2C
# BioGrid	109162	3
# DrugBank	DB00145	Glycine
# DrugBank	DB00289	Atomoxetine
# DrugBank	DB00312	Pentobarbital
# DrugBank	DB00418	Secobarbital
# DrugBank	DB00454	Pethidine
# DrugBank	DB00659	Acamprosate
# DrugBank	DB00996	Gabapentin
# DrugBank	DB01174	Phenobarbital
# DrugBank	DB04896	Milnacipran
# DrugBank	DB06738	Ketobemidone
# Ensembl	ENST00000293190	ENSP00000293190; ENSG00000161509
# ExpressionAtlas	Q14957	baseline and differential
# FUNCTION	NMDE3_HUMAN	NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0014069	postsynaptic density; IEA:Ensembl.
# GO_component	GO:0017146	NMDA selective glutamate receptor complex; IBA:GO_Central.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0004972	NMDA glutamate receptor activity; TAS:ProtInc.
# GO_function	GO:0005088	Ras guanyl-nucleotide exchange factor activity; TAS:Reactome.
# GO_function	GO:0005234	extracellular-glutamate-gated ion channel activity; IEA:InterPro.
# GO_function	GO:0005261	cation channel activity; IEA:Ensembl.
# GO_process	GO:0000165	MAPK cascade; TAS:Reactome.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007215	glutamate receptor signaling pathway; TAS:ProtInc.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:Reactome.
# GO_process	GO:0008104	protein localization; IEA:Ensembl.
# GO_process	GO:0009611	response to wounding; IEA:Ensembl.
# GO_process	GO:0033058	directional locomotion; IEA:Ensembl.
# GO_process	GO:0042177	negative regulation of protein catabolic process; IEA:Ensembl.
# GO_process	GO:0050885	neuromuscular process controlling balance; IEA:Ensembl.
# GO_process	GO:0060079	excitatory postsynaptic potential; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0040011	locomotion
# GOslim_process	GO:0050877	neurological system process
# Genevisible	Q14957	HS
# HGNC	HGNC:4587	GRIN2C
# INTERACTION	NMDE3_HUMAN	Q62936 Dlg3 (xeno); NbExp=6; IntAct=EBI-8285963, EBI-349596; P78352 DLG4; NbExp=4; IntAct=EBI-8285963, EBI-80389; P31016 Dlg4 (xeno); NbExp=2; IntAct=EBI-8285963, EBI-375655; 
# IntAct	Q14957	3
# InterPro	IPR001320	Iontro_rcpt
# InterPro	IPR001508	Iono_rcpt_met
# InterPro	IPR001828	ANF_lig-bd_rcpt
# InterPro	IPR018884	NMDAR2_C
# InterPro	IPR019594	Glu/Gly-bd
# InterPro	IPR028082	Peripla_BP_I
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04713	Circadian entrainment
# KEGG_Pathway	ko04720	Long-term potentiation
# KEGG_Pathway	ko04724	Glutamatergic synapse
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05014	Amyotrophic lateral sclerosis (ALS)
# KEGG_Pathway	ko05030	Cocaine addiction
# KEGG_Pathway	ko05031	Amphetamine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# KEGG_Pathway	ko05034	Alcoholism
# MIM	138254	gene
# Organism	NMDE3_HUMAN	Homo sapiens (Human)
# PRINTS	PR00177	NMDARECEPTOR
# Pfam	PF00060	Lig_chan
# Pfam	PF01094	ANF_receptor
# Pfam	PF10565	NMDAR2_C
# Pfam	PF10613	Lig_chan-Glu_bd
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-438066	Unblocking of NMDA receptor, glutamate binding and activation
# Reactome	R-HSA-442729	CREB phosphorylation through the activation of CaMKII
# Reactome	R-HSA-442982	Ras activation uopn Ca2+ infux through NMDA receptor
# Reactome	R-HSA-5673001	RAF/MAP kinase cascade
# Reactome	R-HSA-6794361	Interactions of neurexins and neuroligins at synapses
# Reactome	R-HSA-8849932	SALM protein interactions at the synapses
# RecName	NMDE3_HUMAN	Glutamate receptor ionotropic, NMDA 2C
# RefSeq	NP_000826	NM_000835.4
# SIMILARITY	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2C/GRIN2C subfamily. {ECO	0000305}.
# SMART	SM00079	PBPe
# SMART	SM00918	Lig_chan-Glu_bd
# SUBCELLULAR LOCATION	NMDE3_HUMAN	Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Interacts with PDZ domains of PATJ and DLG4 (By similarity). Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes. {ECO:0000250, ECO	0000269|PubMed:21300787}. 
# SUPFAM	SSF53822	SSF53822
# TCDB	1.A.10.1	the glutamate-gated ion channel (gic) family of neurotransmitter receptors
# TISSUE SPECIFICITY	NMDE3_HUMAN	Mainly expressed in brain with predominant expression is in the cerebellum, also present in the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei and thalamus. Detected in the heart, skeletal muscle and pancreas. 
# UCSC	uc002jlt	human
# eggNOG	ENOG410XNUR	LUCA
# eggNOG	KOG1053	Eukaryota
BLAST	swissprot:NMDE3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NMDE3_HUMAN
BioCyc	ZFISH:ENSG00000161509-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000161509-MONOMER
COXPRESdb	2905	http://coxpresdb.jp/data/gene/2905.shtml
CleanEx	HS_GRIN2C	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GRIN2C
DOI	10.1016/S0169-328X(96)00146-5	http://dx.doi.org/10.1016/S0169-328X(96)00146-5
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1128/MCB.01044-10	http://dx.doi.org/10.1128/MCB.01044-10
DrugBank	DB00145	http://www.drugbank.ca/drugs/DB00145
DrugBank	DB00289	http://www.drugbank.ca/drugs/DB00289
DrugBank	DB00312	http://www.drugbank.ca/drugs/DB00312
DrugBank	DB00418	http://www.drugbank.ca/drugs/DB00418
DrugBank	DB00454	http://www.drugbank.ca/drugs/DB00454
DrugBank	DB00659	http://www.drugbank.ca/drugs/DB00659
DrugBank	DB00996	http://www.drugbank.ca/drugs/DB00996
DrugBank	DB01174	http://www.drugbank.ca/drugs/DB01174
DrugBank	DB04896	http://www.drugbank.ca/drugs/DB04896
DrugBank	DB06738	http://www.drugbank.ca/drugs/DB06738
EMBL	AC068874	http://www.ebi.ac.uk/ena/data/view/AC068874
EMBL	BC140801	http://www.ebi.ac.uk/ena/data/view/BC140801
EMBL	L76224	http://www.ebi.ac.uk/ena/data/view/L76224
Ensembl	ENST00000293190	http://www.ensembl.org/id/ENST00000293190
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0014069	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014069
GO_component	GO:0017146	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017146
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0004972	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004972
GO_function	GO:0005088	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005088
GO_function	GO:0005234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005234
GO_function	GO:0005261	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005261
GO_process	GO:0000165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000165
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007215
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0008104	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008104
GO_process	GO:0009611	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009611
GO_process	GO:0033058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033058
GO_process	GO:0042177	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042177
GO_process	GO:0050885	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050885
GO_process	GO:0060079	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060079
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0040011	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	GRIN2C	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GRIN2C
GeneID	2905	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2905
GeneTree	ENSGT00760000119186	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119186
H-InvDB	HIX0039170	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0039170
HGNC	HGNC:4587	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4587
HOVERGEN	HBG052636	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052636&db=HOVERGEN
HPA	CAB021094	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB021094
InParanoid	Q14957	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q14957
IntAct	Q14957	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q14957*
InterPro	IPR001320	http://www.ebi.ac.uk/interpro/entry/IPR001320
InterPro	IPR001508	http://www.ebi.ac.uk/interpro/entry/IPR001508
InterPro	IPR001828	http://www.ebi.ac.uk/interpro/entry/IPR001828
InterPro	IPR018884	http://www.ebi.ac.uk/interpro/entry/IPR018884
InterPro	IPR019594	http://www.ebi.ac.uk/interpro/entry/IPR019594
InterPro	IPR028082	http://www.ebi.ac.uk/interpro/entry/IPR028082
Jabion	2905	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2905
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:2905	http://www.genome.jp/dbget-bin/www_bget?hsa:2905
KEGG_Orthology	KO:K05211	http://www.genome.jp/dbget-bin/www_bget?KO:K05211
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04713	http://www.genome.jp/kegg-bin/show_pathway?ko04713
KEGG_Pathway	ko04720	http://www.genome.jp/kegg-bin/show_pathway?ko04720
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05014	http://www.genome.jp/kegg-bin/show_pathway?ko05014
KEGG_Pathway	ko05030	http://www.genome.jp/kegg-bin/show_pathway?ko05030
KEGG_Pathway	ko05031	http://www.genome.jp/kegg-bin/show_pathway?ko05031
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
KEGG_Pathway	ko05034	http://www.genome.jp/kegg-bin/show_pathway?ko05034
MIM	138254	http://www.ncbi.nlm.nih.gov/omim/138254
MINT	MINT-1776011	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1776011
OMA	REACQEG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=REACQEG
OrthoDB	EOG091G09KH	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G09KH
PRINTS	PR00177	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00177
PSORT	swissprot:NMDE3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NMDE3_HUMAN
PSORT-B	swissprot:NMDE3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NMDE3_HUMAN
PSORT2	swissprot:NMDE3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NMDE3_HUMAN
Pfam	PF00060	http://pfam.xfam.org/family/PF00060
Pfam	PF01094	http://pfam.xfam.org/family/PF01094
Pfam	PF10565	http://pfam.xfam.org/family/PF10565
Pfam	PF10613	http://pfam.xfam.org/family/PF10613
PharmGKB	PA28981	http://www.pharmgkb.org/do/serve?objId=PA28981&objCls=Gene
Phobius	swissprot:NMDE3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NMDE3_HUMAN
PhylomeDB	Q14957	http://phylomedb.org/?seqid=Q14957
ProteinModelPortal	Q14957	http://www.proteinmodelportal.org/query/uniprot/Q14957
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	21300787	http://www.ncbi.nlm.nih.gov/pubmed/21300787
PubMed	9037519	http://www.ncbi.nlm.nih.gov/pubmed/9037519
Reactome	R-HSA-438066	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-438066
Reactome	R-HSA-442729	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442729
Reactome	R-HSA-442982	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442982
Reactome	R-HSA-5673001	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5673001
Reactome	R-HSA-6794361	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6794361
Reactome	R-HSA-8849932	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8849932
RefSeq	NP_000826	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000826
SMART	SM00079	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00079
SMART	SM00918	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00918
STRING	9606.ENSP00000293190	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000293190&targetmode=cogs
SUPFAM	SSF53822	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822
TCDB	1.A.10.1	http://www.tcdb.org/search/result.php?tc=1.A.10.1
UCSC	uc002jlt	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002jlt&org=rat
UniGene	Hs.436980	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.436980
UniProtKB	NMDE3_HUMAN	http://www.uniprot.org/uniprot/NMDE3_HUMAN
UniProtKB-AC	Q14957	http://www.uniprot.org/uniprot/Q14957
charge	swissprot:NMDE3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NMDE3_HUMAN
eggNOG	ENOG410XNUR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNUR
eggNOG	KOG1053	http://eggnogapi.embl.de/nog_data/html/tree/KOG1053
epestfind	swissprot:NMDE3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NMDE3_HUMAN
garnier	swissprot:NMDE3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NMDE3_HUMAN
helixturnhelix	swissprot:NMDE3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NMDE3_HUMAN
hmoment	swissprot:NMDE3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NMDE3_HUMAN
iep	swissprot:NMDE3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NMDE3_HUMAN
inforesidue	swissprot:NMDE3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NMDE3_HUMAN
neXtProt	NX_Q14957	http://www.nextprot.org/db/entry/NX_Q14957
octanol	swissprot:NMDE3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NMDE3_HUMAN
pepcoil	swissprot:NMDE3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NMDE3_HUMAN
pepdigest	swissprot:NMDE3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NMDE3_HUMAN
pepinfo	swissprot:NMDE3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NMDE3_HUMAN
pepnet	swissprot:NMDE3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NMDE3_HUMAN
pepstats	swissprot:NMDE3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NMDE3_HUMAN
pepwheel	swissprot:NMDE3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NMDE3_HUMAN
pepwindow	swissprot:NMDE3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NMDE3_HUMAN
sigcleave	swissprot:NMDE3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NMDE3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	NPAL3_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6P499-1; Sequence=Displayed; Name=2; IsoId=Q6P499-2; Sequence=VSP_019445; Note=No experimental confirmation available.; Name=3; IsoId=Q6P499-3; Sequence=VSP_019446, VSP_019447; Note=No experimental confirmation available.; 
# BioGrid	121434	3
# CCDS	CCDS30631	-. [Q6P499-1]
# CCDS	CCDS81280	-. [Q6P499-3]
# CCDS	CCDS81282	-. [Q6P499-2]
# ChiTaRS	NIPAL3	human
# Ensembl	ENST00000003912	ENSP00000003912; ENSG00000001461. [Q6P499-2]
# Ensembl	ENST00000358028	ENSP00000350722; ENSG00000001461. [Q6P499-3]
# Ensembl	ENST00000374399	ENSP00000363520; ENSG00000001461. [Q6P499-1]
# ExpressionAtlas	Q6P499	baseline and differential
# GO_component	GO:0016020	membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015095	magnesium ion transmembrane transporter activity; IEA:InterPro.
# GO_process	GO:0002377	immunoglobulin production; IEA:Ensembl.
# GO_process	GO:0015693	magnesium ion transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006810	transport
# Genevisible	Q6P499	HS
# HGNC	HGNC:25233	NIPAL3
# INTERACTION	NPAL3_HUMAN	Q92838 EDA; NbExp=5; IntAct=EBI-10252783, EBI-529425; 
# IntAct	Q6P499	2
# InterPro	IPR008521	Mg_trans_NIPA
# Organism	NPAL3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12570	PTHR12570
# Pfam	PF05653	Mg_trans_NIPA
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-5223345	Miscellaneous transport and binding events
# RecName	NPAL3_HUMAN	NIPA-like protein 3
# RefSeq	NP_001309783	NM_001322854.1. [Q6P499-1]
# RefSeq	NP_001309784	NM_001322855.1. [Q6P499-1]
# RefSeq	NP_001309785	NM_001322856.1. [Q6P499-1]
# RefSeq	NP_001309786	NM_001322857.1. [Q6P499-1]
# RefSeq	NP_001309791	NM_001322862.1. [Q6P499-2]
# RefSeq	NP_001309792	NM_001322863.1. [Q6P499-2]
# RefSeq	NP_001309794	NM_001322865.1. [Q6P499-3]
# RefSeq	NP_065181	NM_020448.4. [Q6P499-1]
# SIMILARITY	Belongs to the NIPA family. {ECO	0000305}.
# SUBCELLULAR LOCATION	NPAL3_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	2.A.7.25	the drug/metabolite transporter (dmt) superfamily
# UCSC	uc001bjh	human. [Q6P499-1]
# eggNOG	ENOG410XNR8	LUCA
# eggNOG	KOG2922	Eukaryota
BLAST	swissprot:NPAL3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NPAL3_HUMAN
COXPRESdb	57185	http://coxpresdb.jp/data/gene/57185.shtml
CleanEx	HS_NPAL3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_NPAL3
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AK312433	http://www.ebi.ac.uk/ena/data/view/AK312433
EMBL	AL031431	http://www.ebi.ac.uk/ena/data/view/AL031431
EMBL	AL031431	http://www.ebi.ac.uk/ena/data/view/AL031431
EMBL	AL031431	http://www.ebi.ac.uk/ena/data/view/AL031431
EMBL	BC001265	http://www.ebi.ac.uk/ena/data/view/BC001265
EMBL	BC063583	http://www.ebi.ac.uk/ena/data/view/BC063583
EMBL	BX640883	http://www.ebi.ac.uk/ena/data/view/BX640883
EMBL	CH471134	http://www.ebi.ac.uk/ena/data/view/CH471134
Ensembl	ENST00000003912	http://www.ensembl.org/id/ENST00000003912
Ensembl	ENST00000358028	http://www.ensembl.org/id/ENST00000358028
Ensembl	ENST00000374399	http://www.ensembl.org/id/ENST00000374399
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015095
GO_process	GO:0002377	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002377
GO_process	GO:0015693	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015693
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	NIPAL3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=NIPAL3
GeneID	57185	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57185
GeneTree	ENSGT00550000074395	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074395
H-InvDB	HIX0000263	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0000263
HGNC	HGNC:25233	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:25233
HOGENOM	HOG000230865	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230865&db=HOGENOM6
HOVERGEN	HBG069791	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG069791&db=HOVERGEN
HPA	HPA039978	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA039978
InParanoid	Q6P499	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6P499
IntAct	Q6P499	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q6P499*
InterPro	IPR008521	http://www.ebi.ac.uk/interpro/entry/IPR008521
Jabion	57185	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=57185
KEGG_Gene	hsa:57185	http://www.genome.jp/dbget-bin/www_bget?hsa:57185
OMA	YMLVEII	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YMLVEII
OrthoDB	EOG091G09Z6	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G09Z6
PANTHER	PTHR12570	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12570
PSORT	swissprot:NPAL3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NPAL3_HUMAN
PSORT-B	swissprot:NPAL3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NPAL3_HUMAN
PSORT2	swissprot:NPAL3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NPAL3_HUMAN
Pfam	PF05653	http://pfam.xfam.org/family/PF05653
PharmGKB	PA164723927	http://www.pharmgkb.org/do/serve?objId=PA164723927&objCls=Gene
Phobius	swissprot:NPAL3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NPAL3_HUMAN
PhylomeDB	Q6P499	http://phylomedb.org/?seqid=Q6P499
ProteinModelPortal	Q6P499	http://www.proteinmodelportal.org/query/uniprot/Q6P499
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
Reactome	R-HSA-5223345	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5223345
RefSeq	NP_001309783	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001309783
RefSeq	NP_001309784	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001309784
RefSeq	NP_001309785	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001309785
RefSeq	NP_001309786	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001309786
RefSeq	NP_001309791	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001309791
RefSeq	NP_001309792	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001309792
RefSeq	NP_001309794	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001309794
RefSeq	NP_065181	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_065181
STRING	9606.ENSP00000363520	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000363520&targetmode=cogs
TCDB	2.A.7.25	http://www.tcdb.org/search/result.php?tc=2.A.7.25
UCSC	uc001bjh	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001bjh&org=rat
UniGene	Hs.523442	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.523442
UniProtKB	NPAL3_HUMAN	http://www.uniprot.org/uniprot/NPAL3_HUMAN
UniProtKB-AC	Q6P499	http://www.uniprot.org/uniprot/Q6P499
charge	swissprot:NPAL3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NPAL3_HUMAN
eggNOG	ENOG410XNR8	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNR8
eggNOG	KOG2922	http://eggnogapi.embl.de/nog_data/html/tree/KOG2922
epestfind	swissprot:NPAL3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NPAL3_HUMAN
garnier	swissprot:NPAL3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NPAL3_HUMAN
helixturnhelix	swissprot:NPAL3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NPAL3_HUMAN
hmoment	swissprot:NPAL3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NPAL3_HUMAN
iep	swissprot:NPAL3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NPAL3_HUMAN
inforesidue	swissprot:NPAL3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NPAL3_HUMAN
neXtProt	NX_Q6P499	http://www.nextprot.org/db/entry/NX_Q6P499
octanol	swissprot:NPAL3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NPAL3_HUMAN
pepcoil	swissprot:NPAL3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NPAL3_HUMAN
pepdigest	swissprot:NPAL3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NPAL3_HUMAN
pepinfo	swissprot:NPAL3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NPAL3_HUMAN
pepnet	swissprot:NPAL3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NPAL3_HUMAN
pepstats	swissprot:NPAL3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NPAL3_HUMAN
pepwheel	swissprot:NPAL3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NPAL3_HUMAN
pepwindow	swissprot:NPAL3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NPAL3_HUMAN
sigcleave	swissprot:NPAL3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NPAL3_HUMAN
## Database	ID	URL or Descriptions
# AltName	VATB2_HUMAN	Endomembrane proton pump 58 kDa subunit
# AltName	VATB2_HUMAN	HO57
# AltName	VATB2_HUMAN	Vacuolar proton pump subunit B 2
# BioGrid	107009	114
# ChiTaRS	ATP6V1B2	human
# DISEASE	VATB2_HUMAN	Zimmermann-Laband syndrome 2 (ZLS2) [MIM 616455]  A disorder characterized by gingival fibromatosis, dysplastic or absent nails, finger abnormalities, hepatosplenomegaly, and abnormalities of the cartilage of the nose and/or ears. {ECO 0000269|PubMed 24913193, ECO 0000269|PubMed 25915598}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB05260	Gallium nitrate
# Ensembl	ENST00000276390	ENSP00000276390; ENSG00000147416
# ExpressionAtlas	P21281	baseline and differential
# FUNCTION	VATB2_HUMAN	Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. 
# GO_component	GO:0001726	ruffle; IEA:Ensembl.
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005829	cytosol; ISS:UniProtKB.
# GO_component	GO:0005886	plasma membrane; ISS:UniProtKB.
# GO_component	GO:0005902	microvillus; IEA:Ensembl.
# GO_component	GO:0012505	endomembrane system; IEA:UniProtKB-SubCell.
# GO_component	GO:0016021	integral component of membrane; IEA:Ensembl.
# GO_component	GO:0033180	proton-transporting V-type ATPase, V1 domain; IEA:InterPro.
# GO_component	GO:0042470	melanosome; IEA:UniProtKB-SubCell.
# GO_component	GO:0043209	myelin sheath; IEA:Ensembl.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005524	ATP binding; IEA:InterPro.
# GO_function	GO:0015078	hydrogen ion transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism; TAS:ProtInc.
# GO_process	GO:0008286	insulin receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0015991	ATP hydrolysis coupled proton transport; IEA:InterPro.
# GO_process	GO:0015992	proton transport; TAS:ProtInc.
# GO_process	GO:0016241	regulation of macroautophagy; NAS:ParkinsonsUK-UCL.
# GO_process	GO:0033572	transferrin transport; TAS:Reactome.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0046034	ATP metabolic process; IEA:InterPro.
# GO_process	GO:0090383	phagosome acidification; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 1.
# Genevisible	P21281	HS
# HAMAP	MF_00310	ATP_synth_B_arch
# HGNC	HGNC:854	ATP6V1B2
# INTERACTION	VATB2_HUMAN	P15884 TCF4; NbExp=3; IntAct=EBI-4290814, EBI-533224; 
# IntAct	P21281	36
# InterPro	IPR000194	ATPase_F1/V1/A1_a/bsu_nucl-bd
# InterPro	IPR004100	ATPase_F1/V1/A1_a/bsu_N
# InterPro	IPR005723	ATPase_V1-cplx_bsu
# InterPro	IPR020003	ATPase_a/bsu_AS
# InterPro	IPR022879	V-ATPase_su_B/beta
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Disease	H01573	[Skeletal dysplasia; Developmental disorder] Zimmermann-Laband syndrome (ZLS)
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04966	Collecting duct acid secretion
# KEGG_Pathway	ko05110	Vibrio cholerae infection
# KEGG_Pathway	ko05120	Epithelial cell signaling in Helicobacter pylori infection
# KEGG_Pathway	ko05323	Rheumatoid arthritis
# MIM	606939	gene
# MIM	616455	phenotype
# Organism	VATB2_HUMAN	Homo sapiens (Human)
# Orphanet	79499	Autosomal dominant deafness-onychodystrophy syndrome
# PIR	B44138	B44138
# PIR	I39208	I39208
# PIRSF	PIRSF039114	V-ATPsynth_beta/V-ATPase_B
# PROSITE	PS00152	ATPASE_ALPHA_BETA
# Pfam	PF00006	ATP-synt_ab
# Pfam	PF02874	ATP-synt_ab_N
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-1222556	ROS, RNS production in response to bacteria
# Reactome	R-HSA-77387	Insulin receptor recycling
# Reactome	R-HSA-917977	Transferrin endocytosis and recycling
# Reactome	R-HSA-983712	Ion channel transport
# RecName	VATB2_HUMAN	V-type proton ATPase subunit B, brain isoform
# RefSeq	NP_001684	NM_001693.3
# SIMILARITY	Belongs to the ATPase alpha/beta chains family. {ECO	0000305}.
# SUBCELLULAR LOCATION	VATB2_HUMAN	Endomembrane system; Peripheral membrane protein. Melanosome. Note=Endomembrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. 
# SUBUNIT	V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component	 the proteolipid protein). 
# SUPFAM	SSF52540	SSF52540
# TCDB	3.A.2.2	the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily
# TIGRFAMs	TIGR01040	V-ATPase_V1_B
# UCSC	uc003wzp	human
# eggNOG	COG1156	LUCA
# eggNOG	KOG1351	Eukaryota
BLAST	swissprot:VATB2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VATB2_HUMAN
BioCyc	MetaCyc:HS07429-MONOMER	http://biocyc.org/getid?id=MetaCyc:HS07429-MONOMER
BioCyc	ZFISH:HS07429-MONOMER	http://biocyc.org/getid?id=ZFISH:HS07429-MONOMER
COG	COG1156	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1156
COXPRESdb	526	http://coxpresdb.jp/data/gene/526.shtml
CleanEx	HS_ATP6V1B2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP6V1B2
DIP	DIP-47433N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47433N
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1021/pr025562r	http://dx.doi.org/10.1021/pr025562r
DOI	10.1021/pr060363j	http://dx.doi.org/10.1021/pr060363j
DOI	10.1038/cr.2014.77	http://dx.doi.org/10.1038/cr.2014.77
DOI	10.1038/ng.3282	http://dx.doi.org/10.1038/ng.3282
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.89.8.3541	http://dx.doi.org/10.1073/pnas.89.8.3541
DOI	10.1074/jbc.270.13.7320	http://dx.doi.org/10.1074/jbc.270.13.7320
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DrugBank	DB05260	http://www.drugbank.ca/drugs/DB05260
EMBL	AK312372	http://www.ebi.ac.uk/ena/data/view/AK312372
EMBL	BC003100	http://www.ebi.ac.uk/ena/data/view/BC003100
EMBL	BC007309	http://www.ebi.ac.uk/ena/data/view/BC007309
EMBL	BC030640	http://www.ebi.ac.uk/ena/data/view/BC030640
EMBL	CH471080	http://www.ebi.ac.uk/ena/data/view/CH471080
EMBL	CH471080	http://www.ebi.ac.uk/ena/data/view/CH471080
EMBL	L35249	http://www.ebi.ac.uk/ena/data/view/L35249
EMBL	M60346	http://www.ebi.ac.uk/ena/data/view/M60346
EMBL	X62949	http://www.ebi.ac.uk/ena/data/view/X62949
EMBL	Z37165	http://www.ebi.ac.uk/ena/data/view/Z37165
Ensembl	ENST00000276390	http://www.ensembl.org/id/ENST00000276390
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0001726	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001726
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005902
GO_component	GO:0012505	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0012505
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0033180	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033180
GO_component	GO:0042470	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042470
GO_component	GO:0043209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043209
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0015078	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015078
GO_function	GO:0046961	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046961
GO_process	GO:0008286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008286
GO_process	GO:0015991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015991
GO_process	GO:0015992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992
GO_process	GO:0016241	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016241
GO_process	GO:0033572	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033572
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0046034	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046034
GO_process	GO:0090383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090383
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ATP6V1B2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP6V1B2
GeneID	526	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=526
GeneTree	ENSGT00550000074724	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074724
HAMAP	MF_00310	http://hamap.expasy.org/unirule/MF_00310
HGNC	HGNC:854	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:854
HOGENOM	HOG000165320	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000165320&db=HOGENOM6
HOVERGEN	HBG002176	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG002176&db=HOVERGEN
HPA	HPA008147	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA008147
InParanoid	P21281	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21281
IntAct	P21281	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21281*
InterPro	IPR000194	http://www.ebi.ac.uk/interpro/entry/IPR000194
InterPro	IPR004100	http://www.ebi.ac.uk/interpro/entry/IPR004100
InterPro	IPR005723	http://www.ebi.ac.uk/interpro/entry/IPR005723
InterPro	IPR020003	http://www.ebi.ac.uk/interpro/entry/IPR020003
InterPro	IPR022879	http://www.ebi.ac.uk/interpro/entry/IPR022879
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	526	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=526
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Disease	H01573	http://www.genome.jp/dbget-bin/www_bget?H01573
KEGG_Gene	hsa:526	http://www.genome.jp/dbget-bin/www_bget?hsa:526
KEGG_Orthology	KO:K02147	http://www.genome.jp/dbget-bin/www_bget?KO:K02147
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04966	http://www.genome.jp/kegg-bin/show_pathway?ko04966
KEGG_Pathway	ko05110	http://www.genome.jp/kegg-bin/show_pathway?ko05110
KEGG_Pathway	ko05120	http://www.genome.jp/kegg-bin/show_pathway?ko05120
KEGG_Pathway	ko05323	http://www.genome.jp/kegg-bin/show_pathway?ko05323
MIM	606939	http://www.ncbi.nlm.nih.gov/omim/606939
MIM	616455	http://www.ncbi.nlm.nih.gov/omim/616455
MINT	MINT-5004128	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5004128
OMA	WRERRYL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WRERRYL
Orphanet	79499	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=79499
OrthoDB	EOG091G04TR	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G04TR
PROSITE	PS00152	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00152
PSORT	swissprot:VATB2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VATB2_HUMAN
PSORT-B	swissprot:VATB2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VATB2_HUMAN
PSORT2	swissprot:VATB2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VATB2_HUMAN
Pfam	PF00006	http://pfam.xfam.org/family/PF00006
Pfam	PF02874	http://pfam.xfam.org/family/PF02874
PharmGKB	PA25155	http://www.pharmgkb.org/do/serve?objId=PA25155&objCls=Gene
Phobius	swissprot:VATB2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VATB2_HUMAN
PhylomeDB	P21281	http://phylomedb.org/?seqid=P21281
ProteinModelPortal	P21281	http://www.proteinmodelportal.org/query/uniprot/P21281
PubMed	12643545	http://www.ncbi.nlm.nih.gov/pubmed/12643545
PubMed	1373501	http://www.ncbi.nlm.nih.gov/pubmed/1373501
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17081065	http://www.ncbi.nlm.nih.gov/pubmed/17081065
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	2145275	http://www.ncbi.nlm.nih.gov/pubmed/2145275
PubMed	24913193	http://www.ncbi.nlm.nih.gov/pubmed/24913193
PubMed	25915598	http://www.ncbi.nlm.nih.gov/pubmed/25915598
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	7706273	http://www.ncbi.nlm.nih.gov/pubmed/7706273
PubMed	7945239	http://www.ncbi.nlm.nih.gov/pubmed/7945239
Reactome	R-HSA-1222556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1222556
Reactome	R-HSA-77387	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-77387
Reactome	R-HSA-917977	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917977
Reactome	R-HSA-983712	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983712
RefSeq	NP_001684	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001684
SMR	P21281	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21281
STRING	9606.ENSP00000276390	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000276390&targetmode=cogs
STRING	COG1156	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1156&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TCDB	3.A.2.2	http://www.tcdb.org/search/result.php?tc=3.A.2.2
TIGRFAMs	TIGR01040	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01040
UCSC	uc003wzp	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003wzp&org=rat
UniGene	Hs.295917	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.295917
UniProtKB	VATB2_HUMAN	http://www.uniprot.org/uniprot/VATB2_HUMAN
UniProtKB-AC	P21281	http://www.uniprot.org/uniprot/P21281
charge	swissprot:VATB2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VATB2_HUMAN
eggNOG	COG1156	http://eggnogapi.embl.de/nog_data/html/tree/COG1156
eggNOG	KOG1351	http://eggnogapi.embl.de/nog_data/html/tree/KOG1351
epestfind	swissprot:VATB2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VATB2_HUMAN
garnier	swissprot:VATB2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VATB2_HUMAN
helixturnhelix	swissprot:VATB2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VATB2_HUMAN
hmoment	swissprot:VATB2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VATB2_HUMAN
iep	swissprot:VATB2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VATB2_HUMAN
inforesidue	swissprot:VATB2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VATB2_HUMAN
neXtProt	NX_P21281	http://www.nextprot.org/db/entry/NX_P21281
octanol	swissprot:VATB2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VATB2_HUMAN
pepcoil	swissprot:VATB2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VATB2_HUMAN
pepdigest	swissprot:VATB2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VATB2_HUMAN
pepinfo	swissprot:VATB2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VATB2_HUMAN
pepnet	swissprot:VATB2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VATB2_HUMAN
pepstats	swissprot:VATB2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VATB2_HUMAN
pepwheel	swissprot:VATB2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VATB2_HUMAN
pepwindow	swissprot:VATB2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VATB2_HUMAN
sigcleave	swissprot:VATB2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VATB2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	NPAL2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H841-1; Sequence=Displayed; Name=2; IsoId=Q9H841-2; Sequence=VSP_056271; Note=No experimental confirmation available.; 
# CCDS	CCDS6278	-. [Q9H841-1]
# CCDS	CCDS83310	-. [Q9H841-2]
# ChiTaRS	NIPAL2	human
# Ensembl	ENST00000341166	ENSP00000339256; ENSG00000104361. [Q9H841-1]
# Ensembl	ENST00000430223	ENSP00000407087; ENSG00000104361. [Q9H841-2]
# GO_component	GO:0016020	membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015095	magnesium ion transmembrane transporter activity; IEA:InterPro.
# GO_process	GO:0015693	magnesium ion transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q9H841	HS
# HGNC	HGNC:25854	NIPAL2
# InterPro	IPR008521	Mg_trans_NIPA
# Organism	NPAL2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12570	PTHR12570
# Pfam	PF05653	Mg_trans_NIPA
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-5223345	Miscellaneous transport and binding events
# RecName	NPAL2_HUMAN	NIPA-like protein 2
# RefSeq	NP_001308564	NM_001321635.1. [Q9H841-2]
# RefSeq	NP_001308565	NM_001321636.1
# RefSeq	NP_079035	NM_024759.2. [Q9H841-1]
# SIMILARITY	Belongs to the NIPA family. {ECO	0000305}.
# SUBCELLULAR LOCATION	NPAL2_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# UCSC	uc003yil	human. [Q9H841-1]
# eggNOG	ENOG410XNR8	LUCA
# eggNOG	KOG2922	Eukaryota
BLAST	swissprot:NPAL2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NPAL2_HUMAN
BioCyc	ZFISH:ENSG00000104361-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000104361-MONOMER
COXPRESdb	79815	http://coxpresdb.jp/data/gene/79815.shtml
CleanEx	HS_NPAL2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_NPAL2
DOI	10.1038/nature04406	http://dx.doi.org/10.1038/nature04406
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AK024017	http://www.ebi.ac.uk/ena/data/view/AK024017
EMBL	AP003438	http://www.ebi.ac.uk/ena/data/view/AP003438
EMBL	AP003439	http://www.ebi.ac.uk/ena/data/view/AP003439
EMBL	BC132687	http://www.ebi.ac.uk/ena/data/view/BC132687
EMBL	BC144055	http://www.ebi.ac.uk/ena/data/view/BC144055
Ensembl	ENST00000341166	http://www.ensembl.org/id/ENST00000341166
Ensembl	ENST00000430223	http://www.ensembl.org/id/ENST00000430223
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015095
GO_process	GO:0015693	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015693
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	NIPAL2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=NIPAL2
GeneID	79815	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79815
GeneTree	ENSGT00550000074395	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074395
HGNC	HGNC:25854	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:25854
HOGENOM	HOG000230865	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230865&db=HOGENOM6
HOVERGEN	HBG069791	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG069791&db=HOVERGEN
HPA	HPA071759	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA071759
InParanoid	Q9H841	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9H841
InterPro	IPR008521	http://www.ebi.ac.uk/interpro/entry/IPR008521
Jabion	79815	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=79815
KEGG_Gene	hsa:79815	http://www.genome.jp/dbget-bin/www_bget?hsa:79815
OMA	GNIPGKQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GNIPGKQ
OrthoDB	EOG091G09Z6	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G09Z6
PANTHER	PTHR12570	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12570
PSORT	swissprot:NPAL2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NPAL2_HUMAN
PSORT-B	swissprot:NPAL2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NPAL2_HUMAN
PSORT2	swissprot:NPAL2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NPAL2_HUMAN
Pfam	PF05653	http://pfam.xfam.org/family/PF05653
PharmGKB	PA164723926	http://www.pharmgkb.org/do/serve?objId=PA164723926&objCls=Gene
Phobius	swissprot:NPAL2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NPAL2_HUMAN
PhylomeDB	Q9H841	http://phylomedb.org/?seqid=Q9H841
ProteinModelPortal	Q9H841	http://www.proteinmodelportal.org/query/uniprot/Q9H841
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16421571	http://www.ncbi.nlm.nih.gov/pubmed/16421571
Reactome	R-HSA-5223345	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5223345
RefSeq	NP_001308564	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001308564
RefSeq	NP_001308565	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001308565
RefSeq	NP_079035	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_079035
STRING	9606.ENSP00000339256	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000339256&targetmode=cogs
UCSC	uc003yil	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003yil&org=rat
UniGene	Hs.309489	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.309489
UniGene	Hs.732714	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.732714
UniProtKB	NPAL2_HUMAN	http://www.uniprot.org/uniprot/NPAL2_HUMAN
UniProtKB-AC	Q9H841	http://www.uniprot.org/uniprot/Q9H841
charge	swissprot:NPAL2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NPAL2_HUMAN
eggNOG	ENOG410XNR8	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNR8
eggNOG	KOG2922	http://eggnogapi.embl.de/nog_data/html/tree/KOG2922
epestfind	swissprot:NPAL2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NPAL2_HUMAN
garnier	swissprot:NPAL2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NPAL2_HUMAN
helixturnhelix	swissprot:NPAL2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NPAL2_HUMAN
hmoment	swissprot:NPAL2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NPAL2_HUMAN
iep	swissprot:NPAL2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NPAL2_HUMAN
inforesidue	swissprot:NPAL2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NPAL2_HUMAN
neXtProt	NX_Q9H841	http://www.nextprot.org/db/entry/NX_Q9H841
octanol	swissprot:NPAL2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NPAL2_HUMAN
pepcoil	swissprot:NPAL2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NPAL2_HUMAN
pepdigest	swissprot:NPAL2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NPAL2_HUMAN
pepinfo	swissprot:NPAL2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NPAL2_HUMAN
pepnet	swissprot:NPAL2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NPAL2_HUMAN
pepstats	swissprot:NPAL2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NPAL2_HUMAN
pepwheel	swissprot:NPAL2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NPAL2_HUMAN
pepwindow	swissprot:NPAL2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NPAL2_HUMAN
sigcleave	swissprot:NPAL2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NPAL2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SL9C1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q4G0N8-1; Sequence=Displayed; Name=2; IsoId=Q4G0N8-2; Sequence=VSP_027010; Note=No experimental confirmation available.; 
# AltName	SL9C1_HUMAN	Na(+)/H(+) exchanger 10
# AltName	SL9C1_HUMAN	Solute carrier family 9 member 10
# AltName	SL9C1_HUMAN	Solute carrier family 9 member C1
# AltName	SL9C1_HUMAN	Sperm-specific Na(+)/H(+) exchanger
# CCDS	CCDS33817	-. [Q4G0N8-1]
# CCDS	CCDS82818	-. [Q4G0N8-2]
# DOMAIN	SL9C1_HUMAN	The ion transport-like region is related to the membrane segments of voltage-gated ion channels. Its function is unknown (By similarity). {ECO 0000250}. 
# Ensembl	ENST00000305815	ENSP00000306627; ENSG00000172139. [Q4G0N8-1]
# Ensembl	ENST00000487372	ENSP00000420688; ENSG00000172139. [Q4G0N8-2]
# ExpressionAtlas	Q4G0N8	baseline and differential
# FUNCTION	SL9C1_HUMAN	Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) (By similarity). {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0031514	motile cilium; IEA:UniProtKB-KW.
# GO_function	GO:0005216	ion channel activity; IEA:InterPro.
# GO_function	SL9C1_HUMAN	GO 0015385 sodium proton antiporter activity; IBA GO_Central.
# GO_function	SL9C1_HUMAN	GO 0015386 potassium proton antiporter activity; IBA GO_Central.
# GO_process	GO:0007275	multicellular organism development; IEA:UniProtKB-KW.
# GO_process	GO:0007283	spermatogenesis; IEA:UniProtKB-KW.
# GO_process	GO:0030154	cell differentiation; IEA:UniProtKB-KW.
# GO_process	GO:0030317	flagellated sperm motility; IEA:Ensembl.
# GO_process	GO:0051453	regulation of intracellular pH; IBA:GO_Central.
# GO_process	GO:0071805	potassium ion transmembrane transport; IBA:GO_Central.
# GO_process	GO:0098719	sodium ion import across plasma membrane; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0005929	cilium
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0048870	cell motility
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.120.10	-; 1.
# HGNC	HGNC:31401	SLC9C1
# InterPro	IPR000595	cNMP-bd_dom
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR006153	Cation/H_exchanger
# InterPro	IPR014710	RmlC-like_jellyroll
# InterPro	IPR018422	Cation/H_exchanger_CPA1
# InterPro	IPR018490	cNMP-bd-like
# InterPro	IPR028483	N/H_exchanger_10
# KEGG_Brite	ko02001	Solute carrier family
# MIM	612738	gene
# Organism	SL9C1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10110	PTHR10110; 2
# PANTHER	PTHR10110:SF87	PTHR10110:SF87; 2
# PROSITE	PS50042	CNMP_BINDING_3
# Pfam	PF00027	cNMP_binding
# Pfam	PF00520	Ion_trans
# Pfam	PF00999	Na_H_Exchanger
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	SL9C1_HUMAN	Sodium/hydrogen exchanger 10
# RefSeq	NP_001307460	NM_001320531.1. [Q4G0N8-2]
# RefSeq	NP_898884	NM_183061.2. [Q4G0N8-1]
# SEQUENCE CAUTION	Sequence=DAA01462.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. {ECO	0000305}. 
# SIMILARITY	Contains 1 cyclic nucleotide-binding domain. {ECO:0000255|PROSITE-ProRule	PRU00060}. 
# SUBCELLULAR LOCATION	SL9C1_HUMAN	Cell projection, cilium, flagellum membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUBUNIT	Interacts with soluble adenylyl cyclase (sAC). {ECO	0000250}. 
# SUPFAM	SSF51206	SSF51206
# TCDB	2.A.36.7:the monovalent cation	proton antiporter-1 (cpa1) family
# UCSC	uc003dyu	human. [Q4G0N8-1]
# eggNOG	COG0025	LUCA
# eggNOG	KOG1965	Eukaryota
BLAST	swissprot:SL9C1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SL9C1_HUMAN
COXPRESdb	285335	http://coxpresdb.jp/data/gene/285335.shtml
CleanEx	HS_SLC9A10	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC9A10
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-4-22	http://dx.doi.org/10.1186/1471-2164-4-22
EMBL	AK128084	http://www.ebi.ac.uk/ena/data/view/AK128084
EMBL	BC044801	http://www.ebi.ac.uk/ena/data/view/BC044801
EMBL	BK001328	http://www.ebi.ac.uk/ena/data/view/BK001328
Ensembl	ENST00000305815	http://www.ensembl.org/id/ENST00000305815
Ensembl	ENST00000487372	http://www.ensembl.org/id/ENST00000487372
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0031514	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031514
GO_function	GO:0005216	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005216
GO_function	GO:0015385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015385
GO_function	GO:0015386	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015386
GO_process	GO:0007275	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007275
GO_process	GO:0007283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007283
GO_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GO_process	GO:0030317	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030317
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GO_process	GO:0098719	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098719
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0005929	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005929
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.120.10	http://www.cathdb.info/version/latest/superfamily/2.60.120.10
GeneCards	SLC9C1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC9C1
GeneID	285335	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=285335
GeneTree	ENSGT00530000063840	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063840
H-InvDB	HIX0200547	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0200547
HGNC	HGNC:31401	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:31401
HOGENOM	HOG000169764	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000169764&db=HOGENOM6
HOVERGEN	HBG071202	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG071202&db=HOVERGEN
InParanoid	Q4G0N8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q4G0N8
IntAct	Q4G0N8	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q4G0N8*
InterPro	IPR000595	http://www.ebi.ac.uk/interpro/entry/IPR000595
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR006153	http://www.ebi.ac.uk/interpro/entry/IPR006153
InterPro	IPR014710	http://www.ebi.ac.uk/interpro/entry/IPR014710
InterPro	IPR018422	http://www.ebi.ac.uk/interpro/entry/IPR018422
InterPro	IPR018490	http://www.ebi.ac.uk/interpro/entry/IPR018490
InterPro	IPR028483	http://www.ebi.ac.uk/interpro/entry/IPR028483
Jabion	285335	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=285335
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:285335	http://www.genome.jp/dbget-bin/www_bget?hsa:285335
KEGG_Orthology	KO:K14726	http://www.genome.jp/dbget-bin/www_bget?KO:K14726
MIM	612738	http://www.ncbi.nlm.nih.gov/omim/612738
OMA	KMQLKLC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KMQLKLC
OrthoDB	EOG091G031U	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G031U
PANTHER	PTHR10110	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10110
PANTHER	PTHR10110:SF87	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10110:SF87
PROSITE	PS50042	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50042
PSORT	swissprot:SL9C1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SL9C1_HUMAN
PSORT-B	swissprot:SL9C1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SL9C1_HUMAN
PSORT2	swissprot:SL9C1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SL9C1_HUMAN
Pfam	PF00027	http://pfam.xfam.org/family/PF00027
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF00999	http://pfam.xfam.org/family/PF00999
PharmGKB	PA134914619	http://www.pharmgkb.org/do/serve?objId=PA134914619&objCls=Gene
Phobius	swissprot:SL9C1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SL9C1_HUMAN
PhylomeDB	Q4G0N8	http://phylomedb.org/?seqid=Q4G0N8
ProteinModelPortal	Q4G0N8	http://www.proteinmodelportal.org/query/uniprot/Q4G0N8
PubMed	12783626	http://www.ncbi.nlm.nih.gov/pubmed/12783626
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_001307460	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001307460
RefSeq	NP_898884	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_898884
STRING	9606.ENSP00000306627	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000306627&targetmode=cogs
SUPFAM	SSF51206	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51206
TCDB	2.A.36.7	http://www.tcdb.org/search/result.php?tc=2.A.36.7
UCSC	uc003dyu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003dyu&org=rat
UniGene	Hs.680112	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.680112
UniProtKB	SL9C1_HUMAN	http://www.uniprot.org/uniprot/SL9C1_HUMAN
UniProtKB-AC	Q4G0N8	http://www.uniprot.org/uniprot/Q4G0N8
charge	swissprot:SL9C1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SL9C1_HUMAN
eggNOG	COG0025	http://eggnogapi.embl.de/nog_data/html/tree/COG0025
eggNOG	KOG1965	http://eggnogapi.embl.de/nog_data/html/tree/KOG1965
epestfind	swissprot:SL9C1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SL9C1_HUMAN
garnier	swissprot:SL9C1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SL9C1_HUMAN
helixturnhelix	swissprot:SL9C1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SL9C1_HUMAN
hmoment	swissprot:SL9C1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SL9C1_HUMAN
iep	swissprot:SL9C1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SL9C1_HUMAN
inforesidue	swissprot:SL9C1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SL9C1_HUMAN
neXtProt	NX_Q4G0N8	http://www.nextprot.org/db/entry/NX_Q4G0N8
octanol	swissprot:SL9C1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SL9C1_HUMAN
pepcoil	swissprot:SL9C1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SL9C1_HUMAN
pepdigest	swissprot:SL9C1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SL9C1_HUMAN
pepinfo	swissprot:SL9C1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SL9C1_HUMAN
pepnet	swissprot:SL9C1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SL9C1_HUMAN
pepstats	swissprot:SL9C1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SL9C1_HUMAN
pepwheel	swissprot:SL9C1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SL9C1_HUMAN
pepwindow	swissprot:SL9C1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SL9C1_HUMAN
sigcleave	swissprot:SL9C1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SL9C1_HUMAN
## Database	ID	URL or Descriptions
# AltName	UCRIL_HUMAN	Ubiquinol-cytochrome c reductase Rieske iron-sulfur subunit pseudogene 1
# CAUTION	Could be the product of a pseudogene. {ECO	0000305}.
# COFACTOR	Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI	49601; Note=Binds 1 [2Fe-2S] cluster.; 
# GO_component	GO:0016020	membrane; IEA:InterPro.
# GO_function	GO:0008121	ubiquinol-cytochrome-c reductase activity; IEA:InterPro.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_function	GO:0051537	2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# Gene3D	1.20.5.270	-; 1.
# Gene3D	2.102.10.10	-; 1.
# HGNC	HGNC:12588	UQCRFS1P1
# InterPro	IPR004192	Ubiquinol_cyt_Rdtase_TM
# InterPro	IPR005805	Rieske_Fe-S_prot_C
# InterPro	IPR006317	Ubiquinol_cyt_c_Rdtase_Fe-S-su
# InterPro	IPR011070	Globular_prot_asu/bsu
# InterPro	IPR014349	Rieske_Fe-S_prot
# InterPro	IPR015248	Ubiqinol_cyt_c_Rdtase_N
# InterPro	IPR017941	Rieske_2Fe-2S
# Organism	UCRIL_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10134	PTHR10134
# PRINTS	PR00162	RIESKE
# PROSITE	PS51296	RIESKE
# Pfam	PF00355	Rieske
# Pfam	PF02921	UCR_TM
# Pfam	PF09165	Ubiq-Cytc-red_N
# Proteomes	UP000005640	Unplaced
# RecName	UCRIL_HUMAN	Putative cytochrome b-c1 complex subunit Rieske-like protein 1
# SIMILARITY	Contains 1 Rieske domain. {ECO:0000255|PROSITE- ProRule	PRU00628}. 
# SUPFAM	SSF50022	SSF50022
# SUPFAM	SSF56568	SSF56568
# TIGRFAMs	TIGR01416	Rieske_proteo
# eggNOG	COG0723	LUCA
# eggNOG	KOG1671	Eukaryota
BLAST	swissprot:UCRIL_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:UCRIL_HUMAN
BioCyc	ZFISH:HS11982-MONOMER	http://biocyc.org/getid?id=ZFISH:HS11982-MONOMER
DOI	10.1038/990031	http://dx.doi.org/10.1038/990031
EMBL	CR592425	http://www.ebi.ac.uk/ena/data/view/CR592425
EMBL	Z82206	http://www.ebi.ac.uk/ena/data/view/Z82206
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0008121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008121
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_function	GO:0051537	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
Gene3D	1.20.5.270	http://www.cathdb.info/version/latest/superfamily/1.20.5.270
Gene3D	2.102.10.10	http://www.cathdb.info/version/latest/superfamily/2.102.10.10
GeneCards	UQCRFS1P1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=UQCRFS1P1
HGNC	HGNC:12588	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:12588
HOGENOM	HOG000255193	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000255193&db=HOGENOM6
HOVERGEN	HBG001040	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG001040&db=HOVERGEN
HPA	HPA041863	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA041863
HPA	HPA050339	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA050339
InParanoid	P0C7P4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0C7P4
IntAct	P0C7P4	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0C7P4*
InterPro	IPR004192	http://www.ebi.ac.uk/interpro/entry/IPR004192
InterPro	IPR005805	http://www.ebi.ac.uk/interpro/entry/IPR005805
InterPro	IPR006317	http://www.ebi.ac.uk/interpro/entry/IPR006317
InterPro	IPR011070	http://www.ebi.ac.uk/interpro/entry/IPR011070
InterPro	IPR014349	http://www.ebi.ac.uk/interpro/entry/IPR014349
InterPro	IPR015248	http://www.ebi.ac.uk/interpro/entry/IPR015248
InterPro	IPR017941	http://www.ebi.ac.uk/interpro/entry/IPR017941
PANTHER	PTHR10134	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10134
PRINTS	PR00162	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00162
PROSITE	PS51296	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51296
PSORT	swissprot:UCRIL_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:UCRIL_HUMAN
PSORT-B	swissprot:UCRIL_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:UCRIL_HUMAN
PSORT2	swissprot:UCRIL_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:UCRIL_HUMAN
Pfam	PF00355	http://pfam.xfam.org/family/PF00355
Pfam	PF02921	http://pfam.xfam.org/family/PF02921
Pfam	PF09165	http://pfam.xfam.org/family/PF09165
Phobius	swissprot:UCRIL_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:UCRIL_HUMAN
PhylomeDB	P0C7P4	http://phylomedb.org/?seqid=P0C7P4
ProteinModelPortal	P0C7P4	http://www.proteinmodelportal.org/query/uniprot/P0C7P4
PubMed	10591208	http://www.ncbi.nlm.nih.gov/pubmed/10591208
SMR	P0C7P4	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0C7P4
STRING	9606.ENSP00000306397	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000306397&targetmode=cogs
SUPFAM	SSF50022	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50022
SUPFAM	SSF56568	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56568
TIGRFAMs	TIGR01416	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01416
UniProtKB	UCRIL_HUMAN	http://www.uniprot.org/uniprot/UCRIL_HUMAN
UniProtKB-AC	P0C7P4	http://www.uniprot.org/uniprot/P0C7P4
charge	swissprot:UCRIL_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:UCRIL_HUMAN
eggNOG	COG0723	http://eggnogapi.embl.de/nog_data/html/tree/COG0723
eggNOG	KOG1671	http://eggnogapi.embl.de/nog_data/html/tree/KOG1671
epestfind	swissprot:UCRIL_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:UCRIL_HUMAN
garnier	swissprot:UCRIL_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:UCRIL_HUMAN
helixturnhelix	swissprot:UCRIL_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:UCRIL_HUMAN
hmoment	swissprot:UCRIL_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:UCRIL_HUMAN
iep	swissprot:UCRIL_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:UCRIL_HUMAN
inforesidue	swissprot:UCRIL_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:UCRIL_HUMAN
neXtProt	NX_P0C7P4	http://www.nextprot.org/db/entry/NX_P0C7P4
octanol	swissprot:UCRIL_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:UCRIL_HUMAN
pepcoil	swissprot:UCRIL_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:UCRIL_HUMAN
pepdigest	swissprot:UCRIL_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:UCRIL_HUMAN
pepinfo	swissprot:UCRIL_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:UCRIL_HUMAN
pepnet	swissprot:UCRIL_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:UCRIL_HUMAN
pepstats	swissprot:UCRIL_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:UCRIL_HUMAN
pepwheel	swissprot:UCRIL_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:UCRIL_HUMAN
pepwindow	swissprot:UCRIL_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:UCRIL_HUMAN
sigcleave	swissprot:UCRIL_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:UCRIL_HUMAN
## Database	ID	URL or Descriptions
# AltName	LAT1N_HUMAN	hLAT1 3-transmembrane protein MLAS
# CAUTION	Could be the product of a pseudogene. {ECO	0000305}.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; IEA:InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# HGNC	HGNC:29458	SLC7A5P1
# InterPro	IPR002293	AA/rel_permease1
# Organism	LAT1N_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11785	PTHR11785
# Pfam	PF13520	AA_permease_2
# Proteomes	UP000005640	Unplaced
# RecName	LAT1N_HUMAN	Putative L-type amino acid transporter 1-like protein MLAS
# SIMILARITY	Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	LAT1N_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TISSUE SPECIFICITY	Expressed in peripheral blood mononuclear cells and lymphoid and myeloid cell lines. {ECO:0000269|PubMed	12009310}. 
BLAST	swissprot:LAT1N_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:LAT1N_HUMAN
BioCyc	ZFISH:G66-32114-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32114-MONOMER
DOI	10.1016/S1357-2725(02)00036-5	http://dx.doi.org/10.1016/S1357-2725(02)00036-5
EMBL	AB055226	http://www.ebi.ac.uk/ena/data/view/AB055226
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GeneCards	SLC7A5P1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC7A5P1
HGNC	HGNC:29458	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:29458
HOVERGEN	HBG061804	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG061804&db=HOVERGEN
HPA	HPA052673	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA052673
InParanoid	Q8MH63	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8MH63
InterPro	IPR002293	http://www.ebi.ac.uk/interpro/entry/IPR002293
PANTHER	PTHR11785	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785
PSORT	swissprot:LAT1N_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:LAT1N_HUMAN
PSORT-B	swissprot:LAT1N_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:LAT1N_HUMAN
PSORT2	swissprot:LAT1N_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:LAT1N_HUMAN
Pfam	PF13520	http://pfam.xfam.org/family/PF13520
Phobius	swissprot:LAT1N_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:LAT1N_HUMAN
ProteinModelPortal	Q8MH63	http://www.proteinmodelportal.org/query/uniprot/Q8MH63
PubMed	12009310	http://www.ncbi.nlm.nih.gov/pubmed/12009310
UniGene	Hs.677169	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.677169
UniProtKB	LAT1N_HUMAN	http://www.uniprot.org/uniprot/LAT1N_HUMAN
UniProtKB-AC	Q8MH63	http://www.uniprot.org/uniprot/Q8MH63
charge	swissprot:LAT1N_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:LAT1N_HUMAN
epestfind	swissprot:LAT1N_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:LAT1N_HUMAN
garnier	swissprot:LAT1N_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:LAT1N_HUMAN
helixturnhelix	swissprot:LAT1N_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:LAT1N_HUMAN
hmoment	swissprot:LAT1N_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:LAT1N_HUMAN
iep	swissprot:LAT1N_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:LAT1N_HUMAN
inforesidue	swissprot:LAT1N_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:LAT1N_HUMAN
neXtProt	NX_Q8MH63	http://www.nextprot.org/db/entry/NX_Q8MH63
octanol	swissprot:LAT1N_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:LAT1N_HUMAN
pepcoil	swissprot:LAT1N_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:LAT1N_HUMAN
pepdigest	swissprot:LAT1N_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:LAT1N_HUMAN
pepinfo	swissprot:LAT1N_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:LAT1N_HUMAN
pepnet	swissprot:LAT1N_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:LAT1N_HUMAN
pepstats	swissprot:LAT1N_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:LAT1N_HUMAN
pepwheel	swissprot:LAT1N_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:LAT1N_HUMAN
pepwindow	swissprot:LAT1N_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:LAT1N_HUMAN
sigcleave	swissprot:LAT1N_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:LAT1N_HUMAN
## Database	ID	URL or Descriptions
# AltName	GHC1_HUMAN	Glutamate/H(+) symporter 1
# AltName	GHC1_HUMAN	Solute carrier family 25 member 22
# BioGrid	122862	32
# DISEASE	GHC1_HUMAN	Epileptic encephalopathy, early infantile, 3 (EIEE3) [MIM 609304]  A severe form of epilepsy characterized by frequent tonic seizures or spasms beginning in infancy with a specific EEG finding of suppression-burst patterns, characterized by high- voltage bursts alternating with almost flat suppression phases. Epileptic encephalopathy early infantile type 3 is characterized by a very early onset, erratic and fragmentary myoclonus, massive myoclonus, partial motor seizures and late tonic spasms. The prognosis is poor, with no effective treatment, and children with the condition either die within 1 to 2 years after birth or survive in a persistent vegetative state. {ECO 0000269|PubMed 15592994}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000320230	ENSP00000322020; ENSG00000177542
# Ensembl	ENST00000531214	ENSP00000437236; ENSG00000177542
# Ensembl	ENST00000628067	ENSP00000486058; ENSG00000177542
# ExpressionAtlas	Q9H936	baseline and differential
# FUNCTION	GHC1_HUMAN	Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+). {ECO 0000269|PubMed 11897791}. 
# GO_component	GO:0005654	nucleoplasm; IDA:HPA.
# GO_component	GO:0005739	mitochondrion; IDA:HPA.
# GO_component	GO:0005743	mitochondrial inner membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005313	L-glutamate transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_process	GO:0015813	L-glutamate transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005739	mitochondrion
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Gene3D	1.50.40.10	-; 1.
# Genevisible	Q9H936	HS
# HGNC	HGNC:19954	SLC25A22
# IntAct	Q9H936	26
# InterPro	IPR002067	Mit_carrier
# InterPro	IPR018108	Mitochondrial_sb/sol_carrier
# InterPro	IPR023395	Mt_carrier_dom
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H00606	[Congenital disorder; Epilepsy] Ohtahara syndrome
# MIM	609302	gene
# MIM	609304	phenotype
# Organism	GHC1_HUMAN	Homo sapiens (Human)
# Orphanet	1934	Early infantile epileptic encephalopathy
# Orphanet	1935	Early myoclonic encephalopathy
# Orphanet	293181	Malignant migrating partial seizures of infancy
# PRINTS	PR00926	MITOCARRIER
# PROSITE	PS50920	SOLCAR; 3
# Pfam	PF00153	Mito_carr; 3
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-428643	Organic anion transporters
# RecName	GHC1_HUMAN	Mitochondrial glutamate carrier 1
# RefSeq	NP_001177989	NM_001191060.1
# RefSeq	NP_001177990	NM_001191061.1
# RefSeq	NP_078974	NM_024698.5
# RefSeq	XP_011518671	XM_011520369.1
# RefSeq	XP_011518672	XM_011520370.1
# RefSeq	XP_011518673	XM_011520371.1
# SEQUENCE CAUTION	Sequence=AAH24212.2; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the mitochondrial carrier (TC 2.A.29) family. {ECO	0000305}. 
# SIMILARITY	Contains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule	PRU00282}. 
# SUBCELLULAR LOCATION	GHC1_HUMAN	Mitochondrion inner membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF103506	SSF103506
# TCDB	2.A.29.14	the mitochondrial carrier (mc) family
# TISSUE SPECIFICITY	GHC1_HUMAN	Highly expressed in most tissues. 
# UCSC	uc001lri	human
# eggNOG	ENOG410Y240	LUCA
# eggNOG	KOG0750	Eukaryota
BLAST	swissprot:GHC1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GHC1_HUMAN
BioCyc	ZFISH:ENSG00000177542-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000177542-MONOMER
COXPRESdb	79751	http://coxpresdb.jp/data/gene/79751.shtml
CleanEx	HS_SLC25A22	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC25A22
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M201572200	http://dx.doi.org/10.1074/jbc.M201572200
DOI	10.1086/427564	http://dx.doi.org/10.1086/427564
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AJ428202	http://www.ebi.ac.uk/ena/data/view/AJ428202
EMBL	AK023106	http://www.ebi.ac.uk/ena/data/view/AK023106
EMBL	AK290481	http://www.ebi.ac.uk/ena/data/view/AK290481
EMBL	AP006621	http://www.ebi.ac.uk/ena/data/view/AP006621
EMBL	BC019033	http://www.ebi.ac.uk/ena/data/view/BC019033
EMBL	BC023545	http://www.ebi.ac.uk/ena/data/view/BC023545
EMBL	BC024212	http://www.ebi.ac.uk/ena/data/view/BC024212
Ensembl	ENST00000320230	http://www.ensembl.org/id/ENST00000320230
Ensembl	ENST00000531214	http://www.ensembl.org/id/ENST00000531214
Ensembl	ENST00000628067	http://www.ensembl.org/id/ENST00000628067
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005313	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005313
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_process	GO:0015813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015813
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
Gene3D	1.50.40.10	http://www.cathdb.info/version/latest/superfamily/1.50.40.10
GeneCards	SLC25A22	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC25A22
GeneID	79751	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79751
GeneTree	ENSGT00530000062944	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062944
HGNC	HGNC:19954	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:19954
HOGENOM	HOG000168308	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000168308&db=HOGENOM6
HOVERGEN	HBG039469	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG039469&db=HOVERGEN
HPA	HPA014662	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014662
InParanoid	Q9H936	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9H936
IntAct	Q9H936	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9H936*
InterPro	IPR002067	http://www.ebi.ac.uk/interpro/entry/IPR002067
InterPro	IPR018108	http://www.ebi.ac.uk/interpro/entry/IPR018108
InterPro	IPR023395	http://www.ebi.ac.uk/interpro/entry/IPR023395
Jabion	79751	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=79751
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00606	http://www.genome.jp/dbget-bin/www_bget?H00606
KEGG_Gene	hsa:79751	http://www.genome.jp/dbget-bin/www_bget?hsa:79751
KEGG_Orthology	KO:K15107	http://www.genome.jp/dbget-bin/www_bget?KO:K15107
MIM	609302	http://www.ncbi.nlm.nih.gov/omim/609302
MIM	609304	http://www.ncbi.nlm.nih.gov/omim/609304
OMA	AQRKLMP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AQRKLMP
Orphanet	1934	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1934
Orphanet	1935	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1935
Orphanet	293181	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=293181
OrthoDB	EOG091G08GT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08GT
PRINTS	PR00926	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00926
PROSITE	PS50920	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50920
PSORT	swissprot:GHC1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GHC1_HUMAN
PSORT-B	swissprot:GHC1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GHC1_HUMAN
PSORT2	swissprot:GHC1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GHC1_HUMAN
Pfam	PF00153	http://pfam.xfam.org/family/PF00153
PharmGKB	PA134955826	http://www.pharmgkb.org/do/serve?objId=PA134955826&objCls=Gene
Phobius	swissprot:GHC1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GHC1_HUMAN
PhylomeDB	Q9H936	http://phylomedb.org/?seqid=Q9H936
ProteinModelPortal	Q9H936	http://www.proteinmodelportal.org/query/uniprot/Q9H936
PubMed	11897791	http://www.ncbi.nlm.nih.gov/pubmed/11897791
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15592994	http://www.ncbi.nlm.nih.gov/pubmed/15592994
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-428643	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428643
RefSeq	NP_001177989	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001177989
RefSeq	NP_001177990	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001177990
RefSeq	NP_078974	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_078974
RefSeq	XP_011518671	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011518671
RefSeq	XP_011518672	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011518672
RefSeq	XP_011518673	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011518673
STRING	9606.ENSP00000322020	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000322020&targetmode=cogs
SUPFAM	SSF103506	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103506
TCDB	2.A.29.14	http://www.tcdb.org/search/result.php?tc=2.A.29.14
UCSC	uc001lri	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001lri&org=rat
UniGene	Hs.99486	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.99486
UniProtKB	GHC1_HUMAN	http://www.uniprot.org/uniprot/GHC1_HUMAN
UniProtKB-AC	Q9H936	http://www.uniprot.org/uniprot/Q9H936
charge	swissprot:GHC1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GHC1_HUMAN
eggNOG	ENOG410Y240	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y240
eggNOG	KOG0750	http://eggnogapi.embl.de/nog_data/html/tree/KOG0750
epestfind	swissprot:GHC1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GHC1_HUMAN
garnier	swissprot:GHC1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GHC1_HUMAN
helixturnhelix	swissprot:GHC1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GHC1_HUMAN
hmoment	swissprot:GHC1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GHC1_HUMAN
iep	swissprot:GHC1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GHC1_HUMAN
inforesidue	swissprot:GHC1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GHC1_HUMAN
neXtProt	NX_Q9H936	http://www.nextprot.org/db/entry/NX_Q9H936
octanol	swissprot:GHC1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GHC1_HUMAN
pepcoil	swissprot:GHC1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GHC1_HUMAN
pepdigest	swissprot:GHC1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GHC1_HUMAN
pepinfo	swissprot:GHC1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GHC1_HUMAN
pepnet	swissprot:GHC1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GHC1_HUMAN
pepstats	swissprot:GHC1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GHC1_HUMAN
pepwheel	swissprot:GHC1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GHC1_HUMAN
pepwindow	swissprot:GHC1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GHC1_HUMAN
sigcleave	swissprot:GHC1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GHC1_HUMAN
## Database	ID	URL or Descriptions
# AltName	ATP4B_HUMAN	Gastric H(+)/K(+) ATPase subunit beta
# AltName	ATP4B_HUMAN	Proton pump beta chain
# BioGrid	106986	4
# DOMAIN	ATP4B_HUMAN	The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties. {ECO 0000269|PubMed 19694409}. 
# Ensembl	ENST00000335288	ENSP00000334216; ENSG00000186009
# FUNCTION	ATP4B_HUMAN	Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity. {ECO 0000269|PubMed 19694409}. 
# GO_component	ATP4B_HUMAN	GO 0005890 sodium potassium-exchanging ATPase complex; IEA InterPro.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_function	ATP4B_HUMAN	GO 0008900 hydrogen potassium-exchanging ATPase activity; TAS ProtInc.
# GO_process	GO:0006814	sodium ion transport; IEA:InterPro.
# GO_process	GO:0007155	cell adhesion; IEA:UniProtKB-KW.
# GO_process	GO:0010243	response to organonitrogen compound; IEA:Ensembl.
# GO_process	GO:0032496	response to lipopolysaccharide; IEA:Ensembl.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007155	cell adhesion
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P51164	HS
# HGNC	HGNC:820	ATP4B
# INTERACTION	ATP4B_HUMAN	O95273 CCNDBP1; NbExp=3; IntAct=EBI-3904463, EBI-748961; 
# IntAct	P51164	3
# InterPro	IPR000402	Na/K_ATPase_sub_beta
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04966	Collecting duct acid secretion
# KEGG_Pathway	ko04971	Gastric acid secretion
# MIM	137217	gene
# Organism	ATP4B_HUMAN	Homo sapiens (Human)
# PIR	JH0480	JH0480
# PROSITE	PS00390	ATPASE_NA_K_BETA_1
# PROSITE	PS00391	ATPASE_NA_K_BETA_2
# Pfam	PF00287	Na_K-ATPase
# Proteomes	UP000005640	Chromosome 13
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	ATP4B_HUMAN	Potassium-transporting ATPase subunit beta
# RefSeq	NP_000696	NM_000705.3
# SIMILARITY	Belongs to the X(+)/potassium ATPases subunit beta family. {ECO	0000305}.
# SUBCELLULAR LOCATION	ATP4B_HUMAN	Cell membrane; Single-pass type II membrane protein. 
# SUBUNIT	Composed of two subunits	 alpha (catalytic) and beta. 
# TCDB	3.A.3.1	the p-type atpase (p-atpase) superfamily
# TIGRFAMs	TIGR01107	Na_K_ATPase_bet
# UCSC	uc001vtz	human
# eggNOG	ENOG411150A	LUCA
# eggNOG	KOG3927	Eukaryota
BLAST	swissprot:ATP4B_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ATP4B_HUMAN
BioCyc	MetaCyc:G66-33511-MONOMER	http://biocyc.org/getid?id=MetaCyc:G66-33511-MONOMER
BioCyc	ZFISH:G66-33511-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33511-MONOMER
COXPRESdb	496	http://coxpresdb.jp/data/gene/496.shtml
CleanEx	HS_ATP4B	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP4B
DOI	10.1016/S0006-291X(05)81251-3	http://dx.doi.org/10.1016/S0006-291X(05)81251-3
DOI	10.1016/S0014-5793(97)01017-X	http://dx.doi.org/10.1016/S0014-5793(97)01017-X
DOI	10.1021/bi900868e	http://dx.doi.org/10.1021/bi900868e
DOI	10.1038/nature02379	http://dx.doi.org/10.1038/nature02379
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB008783	http://www.ebi.ac.uk/ena/data/view/AB008783
EMBL	BC029059	http://www.ebi.ac.uk/ena/data/view/BC029059
EMBL	BX537316	http://www.ebi.ac.uk/ena/data/view/BX537316
EMBL	CH471085	http://www.ebi.ac.uk/ena/data/view/CH471085
EMBL	M75110	http://www.ebi.ac.uk/ena/data/view/M75110
Ensembl	ENST00000335288	http://www.ensembl.org/id/ENST00000335288
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005890
GO_function	GO:0008900	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008900
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GO_process	GO:0010243	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010243
GO_process	GO:0032496	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032496
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ATP4B	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP4B
GeneID	496	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=496
GeneTree	ENSGT00550000074530	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074530
HGNC	HGNC:820	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:820
HOGENOM	HOG000039248	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000039248&db=HOGENOM6
HOVERGEN	HBG050603	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050603&db=HOVERGEN
HPA	HPA045400	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA045400
HPA	HPA052649	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA052649
InParanoid	P51164	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P51164
IntAct	P51164	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P51164*
InterPro	IPR000402	http://www.ebi.ac.uk/interpro/entry/IPR000402
Jabion	496	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=496
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:496	http://www.genome.jp/dbget-bin/www_bget?hsa:496
KEGG_Orthology	KO:K01543	http://www.genome.jp/dbget-bin/www_bget?KO:K01543
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04966	http://www.genome.jp/kegg-bin/show_pathway?ko04966
KEGG_Pathway	ko04971	http://www.genome.jp/kegg-bin/show_pathway?ko04971
MIM	137217	http://www.ncbi.nlm.nih.gov/omim/137217
OMA	CKFTADM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CKFTADM
OrthoDB	EOG091G0DJ4	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0DJ4
PROSITE	PS00390	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00390
PROSITE	PS00391	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00391
PSORT	swissprot:ATP4B_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ATP4B_HUMAN
PSORT-B	swissprot:ATP4B_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ATP4B_HUMAN
PSORT2	swissprot:ATP4B_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ATP4B_HUMAN
Pfam	PF00287	http://pfam.xfam.org/family/PF00287
PharmGKB	PA25114	http://www.pharmgkb.org/do/serve?objId=PA25114&objCls=Gene
Phobius	swissprot:ATP4B_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ATP4B_HUMAN
PhylomeDB	P51164	http://phylomedb.org/?seqid=P51164
ProteinModelPortal	P51164	http://www.proteinmodelportal.org/query/uniprot/P51164
PubMed	15057823	http://www.ncbi.nlm.nih.gov/pubmed/15057823
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	1656976	http://www.ncbi.nlm.nih.gov/pubmed/1656976
PubMed	19694409	http://www.ncbi.nlm.nih.gov/pubmed/19694409
PubMed	9315713	http://www.ncbi.nlm.nih.gov/pubmed/9315713
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_000696	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000696
STRING	9606.ENSP00000334216	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000334216&targetmode=cogs
TCDB	3.A.3.1	http://www.tcdb.org/search/result.php?tc=3.A.3.1
TIGRFAMs	TIGR01107	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01107
UCSC	uc001vtz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001vtz&org=rat
UniGene	Hs.434202	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.434202
UniProtKB	ATP4B_HUMAN	http://www.uniprot.org/uniprot/ATP4B_HUMAN
UniProtKB-AC	P51164	http://www.uniprot.org/uniprot/P51164
charge	swissprot:ATP4B_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ATP4B_HUMAN
eggNOG	ENOG411150A	http://eggnogapi.embl.de/nog_data/html/tree/ENOG411150A
eggNOG	KOG3927	http://eggnogapi.embl.de/nog_data/html/tree/KOG3927
epestfind	swissprot:ATP4B_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ATP4B_HUMAN
garnier	swissprot:ATP4B_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ATP4B_HUMAN
helixturnhelix	swissprot:ATP4B_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATP4B_HUMAN
hmoment	swissprot:ATP4B_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ATP4B_HUMAN
iep	swissprot:ATP4B_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ATP4B_HUMAN
inforesidue	swissprot:ATP4B_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ATP4B_HUMAN
neXtProt	NX_P51164	http://www.nextprot.org/db/entry/NX_P51164
octanol	swissprot:ATP4B_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ATP4B_HUMAN
pepcoil	swissprot:ATP4B_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ATP4B_HUMAN
pepdigest	swissprot:ATP4B_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ATP4B_HUMAN
pepinfo	swissprot:ATP4B_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ATP4B_HUMAN
pepnet	swissprot:ATP4B_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ATP4B_HUMAN
pepstats	swissprot:ATP4B_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ATP4B_HUMAN
pepwheel	swissprot:ATP4B_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ATP4B_HUMAN
pepwindow	swissprot:ATP4B_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ATP4B_HUMAN
sigcleave	swissprot:ATP4B_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ATP4B_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P38606-1; Sequence=Displayed; Name=2; IsoId=P38606-2; Sequence=VSP_056408; Note=No experimental confirmation available. Initiator Met-1 is removed. Contains a N-acetylalanine at position 2. {ECO:0000244|PubMed	22814378}; 
# AltName	VATA_HUMAN	V-ATPase 69 kDa subunit
# AltName	VATA_HUMAN	Vacuolar ATPase isoform VA68
# AltName	VATA_HUMAN	Vacuolar proton pump subunit alpha
# BioGrid	107007	99
# CATALYTIC ACTIVITY	VATA_HUMAN	ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out). 
# CCDS	CCDS2976	-. [P38606-1]
# ChiTaRS	ATP6V1A	human
# DrugBank	DB00630	Alendronate
# DrugBank	DB01077	Etidronic acid
# DrugBank	DB01133	Tiludronate
# Ensembl	ENST00000273398	ENSP00000273398; ENSG00000114573. [P38606-1]
# ExpressionAtlas	P38606	baseline and differential
# FUNCTION	VATA_HUMAN	Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. 
# GO_component	GO:0005739	mitochondrion; IEA:Ensembl.
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005829	cytosol; ISS:UniProtKB.
# GO_component	GO:0005886	plasma membrane; ISS:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0005902	microvillus; IEA:Ensembl.
# GO_component	GO:0016324	apical plasma membrane; IEA:Ensembl.
# GO_component	GO:0016469	proton-transporting two-sector ATPase complex; TAS:ProtInc.
# GO_component	GO:0033180	proton-transporting V-type ATPase, V1 domain; IEA:InterPro.
# GO_component	GO:0043209	myelin sheath; IEA:Ensembl.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0008286	insulin receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0015991	ATP hydrolysis coupled proton transport; IEA:InterPro.
# GO_process	GO:0016241	regulation of macroautophagy; NAS:ParkinsonsUK-UCL.
# GO_process	GO:0033572	transferrin transport; TAS:Reactome.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0046034	ATP metabolic process; IEA:InterPro.
# GO_process	GO:0090383	phagosome acidification; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.10.1140.10	-; 1.
# Gene3D	3.40.50.300	-; 2.
# Genevisible	P38606	HS
# HAMAP	MF_00309	ATP_synth_A_arch
# HGNC	HGNC:851	ATP6V1A
# IntAct	P38606	86
# InterPro	IPR000194	ATPase_F1/V1/A1_a/bsu_nucl-bd
# InterPro	IPR004100	ATPase_F1/V1/A1_a/bsu_N
# InterPro	IPR005725	ATPase_V1-cplx_asu
# InterPro	IPR020003	ATPase_a/bsu_AS
# InterPro	IPR022878	V-ATPase_asu
# InterPro	IPR024034	ATPase_F1/V1_bsu_C
# InterPro	IPR027417	P-loop_NTPase
# InterPro	IPR031686	ATP-synth_a_Xtn
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04966	Collecting duct acid secretion
# KEGG_Pathway	ko05110	Vibrio cholerae infection
# KEGG_Pathway	ko05120	Epithelial cell signaling in Helicobacter pylori infection
# KEGG_Pathway	ko05323	Rheumatoid arthritis
# MIM	607027	gene
# Organism	VATA_HUMAN	Homo sapiens (Human)
# PIR	B46091	B46091
# PROSITE	PS00152	ATPASE_ALPHA_BETA
# Pfam	PF00006	ATP-synt_ab
# Pfam	PF02874	ATP-synt_ab_N
# Pfam	PF16886	ATP-synt_ab_Xtn
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-1222556	ROS, RNS production in response to bacteria
# Reactome	R-HSA-77387	Insulin receptor recycling
# Reactome	R-HSA-917977	Transferrin endocytosis and recycling
# Reactome	R-HSA-983712	Ion channel transport
# RecName	VATA_HUMAN	V-type proton ATPase catalytic subunit A
# RefSeq	NP_001681	NM_001690.3. [P38606-1]
# SIMILARITY	Belongs to the ATPase alpha/beta chains family. {ECO	0000305}.
# SUBUNIT	V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component	 the proteolipid protein). 
# SUPFAM	SSF50615	SSF50615
# SUPFAM	SSF52540	SSF52540
# TCDB	3.A.2.2	the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily
# TIGRFAMs	TIGR01042	V-ATPase_V1_A
# TISSUE SPECIFICITY	VATA_HUMAN	Present in all tissues analyzed. 
# UCSC	uc003eao	human. [P38606-1]
# eggNOG	COG1155	LUCA
# eggNOG	KOG1352	Eukaryota
BLAST	swissprot:VATA_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VATA_HUMAN
BioCyc	MetaCyc:HS03781-MONOMER	http://biocyc.org/getid?id=MetaCyc:HS03781-MONOMER
BioCyc	ZFISH:HS03781-MONOMER	http://biocyc.org/getid?id=ZFISH:HS03781-MONOMER
COG	COG1155	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1155
COXPRESdb	523	http://coxpresdb.jp/data/gene/523.shtml
CleanEx	HS_ATP6V1A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP6V1A
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1073/pnas.160270997	http://dx.doi.org/10.1073/pnas.160270997
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DrugBank	DB00630	http://www.drugbank.ca/drugs/DB00630
DrugBank	DB01077	http://www.drugbank.ca/drugs/DB01077
DrugBank	DB01133	http://www.drugbank.ca/drugs/DB01133
EC_number	EC:3.6.3.14	http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.14
EMBL	AC079944	http://www.ebi.ac.uk/ena/data/view/AC079944
EMBL	AC108693	http://www.ebi.ac.uk/ena/data/view/AC108693
EMBL	AF113129	http://www.ebi.ac.uk/ena/data/view/AF113129
EMBL	AK293804	http://www.ebi.ac.uk/ena/data/view/AK293804
EMBL	AK314779	http://www.ebi.ac.uk/ena/data/view/AK314779
EMBL	BC013138	http://www.ebi.ac.uk/ena/data/view/BC013138
EMBL	BT006672	http://www.ebi.ac.uk/ena/data/view/BT006672
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
EMBL	L09235	http://www.ebi.ac.uk/ena/data/view/L09235
ENZYME	3.6.3.14	http://enzyme.expasy.org/EC/3.6.3.14
Ensembl	ENST00000273398	http://www.ensembl.org/id/ENST00000273398
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005902
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0016469	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016469
GO_component	GO:0033180	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033180
GO_component	GO:0043209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043209
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0046961	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046961
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0008286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008286
GO_process	GO:0015991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015991
GO_process	GO:0016241	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016241
GO_process	GO:0033572	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033572
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0046034	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046034
GO_process	GO:0090383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090383
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.10.1140.10	http://www.cathdb.info/version/latest/superfamily/1.10.1140.10
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ATP6V1A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP6V1A
GeneID	523	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=523
GeneTree	ENSGT00550000074787	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074787
HAMAP	MF_00309	http://hamap.expasy.org/unirule/MF_00309
HGNC	HGNC:851	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:851
HOGENOM	HOG000161057	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000161057&db=HOGENOM6
HOVERGEN	HBG053351	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053351&db=HOVERGEN
HPA	CAB006910	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB006910
HPA	HPA035083	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035083
HPA	HPA035084	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035084
InParanoid	P38606	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P38606
IntAct	P38606	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P38606*
IntEnz	3.6.3.14	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.14
InterPro	IPR000194	http://www.ebi.ac.uk/interpro/entry/IPR000194
InterPro	IPR004100	http://www.ebi.ac.uk/interpro/entry/IPR004100
InterPro	IPR005725	http://www.ebi.ac.uk/interpro/entry/IPR005725
InterPro	IPR020003	http://www.ebi.ac.uk/interpro/entry/IPR020003
InterPro	IPR022878	http://www.ebi.ac.uk/interpro/entry/IPR022878
InterPro	IPR024034	http://www.ebi.ac.uk/interpro/entry/IPR024034
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
InterPro	IPR031686	http://www.ebi.ac.uk/interpro/entry/IPR031686
Jabion	523	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=523
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:523	http://www.genome.jp/dbget-bin/www_bget?hsa:523
KEGG_Orthology	KO:K02145	http://www.genome.jp/dbget-bin/www_bget?KO:K02145
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04966	http://www.genome.jp/kegg-bin/show_pathway?ko04966
KEGG_Pathway	ko05110	http://www.genome.jp/kegg-bin/show_pathway?ko05110
KEGG_Pathway	ko05120	http://www.genome.jp/kegg-bin/show_pathway?ko05120
KEGG_Pathway	ko05323	http://www.genome.jp/kegg-bin/show_pathway?ko05323
MIM	607027	http://www.ncbi.nlm.nih.gov/omim/607027
MINT	MINT-224589	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-224589
OMA	YSPYDRF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YSPYDRF
OrthoDB	EOG091G03SR	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G03SR
PROSITE	PS00152	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00152
PSORT	swissprot:VATA_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VATA_HUMAN
PSORT-B	swissprot:VATA_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VATA_HUMAN
PSORT2	swissprot:VATA_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VATA_HUMAN
Pfam	PF00006	http://pfam.xfam.org/family/PF00006
Pfam	PF02874	http://pfam.xfam.org/family/PF02874
Pfam	PF16886	http://pfam.xfam.org/family/PF16886
PharmGKB	PA25152	http://www.pharmgkb.org/do/serve?objId=PA25152&objCls=Gene
Phobius	swissprot:VATA_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VATA_HUMAN
PhylomeDB	P38606	http://phylomedb.org/?seqid=P38606
ProteinModelPortal	P38606	http://www.proteinmodelportal.org/query/uniprot/P38606
PubMed	10931946	http://www.ncbi.nlm.nih.gov/pubmed/10931946
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	8463241	http://www.ncbi.nlm.nih.gov/pubmed/8463241
Reactome	R-HSA-1222556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1222556
Reactome	R-HSA-77387	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-77387
Reactome	R-HSA-917977	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917977
Reactome	R-HSA-983712	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983712
RefSeq	NP_001681	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001681
SMR	P38606	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P38606
STRING	9606.ENSP00000273398	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000273398&targetmode=cogs
STRING	COG1155	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1155&targetmode=cogs
SUPFAM	SSF50615	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50615
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TCDB	3.A.2.2	http://www.tcdb.org/search/result.php?tc=3.A.2.2
TIGRFAMs	TIGR01042	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01042
UCSC	uc003eao	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003eao&org=rat
UniGene	Hs.477155	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.477155
UniProtKB	VATA_HUMAN	http://www.uniprot.org/uniprot/VATA_HUMAN
UniProtKB-AC	P38606	http://www.uniprot.org/uniprot/P38606
charge	swissprot:VATA_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VATA_HUMAN
eggNOG	COG1155	http://eggnogapi.embl.de/nog_data/html/tree/COG1155
eggNOG	KOG1352	http://eggnogapi.embl.de/nog_data/html/tree/KOG1352
epestfind	swissprot:VATA_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VATA_HUMAN
garnier	swissprot:VATA_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VATA_HUMAN
helixturnhelix	swissprot:VATA_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VATA_HUMAN
hmoment	swissprot:VATA_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VATA_HUMAN
iep	swissprot:VATA_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VATA_HUMAN
inforesidue	swissprot:VATA_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VATA_HUMAN
neXtProt	NX_P38606	http://www.nextprot.org/db/entry/NX_P38606
octanol	swissprot:VATA_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VATA_HUMAN
pepcoil	swissprot:VATA_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VATA_HUMAN
pepdigest	swissprot:VATA_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VATA_HUMAN
pepinfo	swissprot:VATA_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VATA_HUMAN
pepnet	swissprot:VATA_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VATA_HUMAN
pepstats	swissprot:VATA_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VATA_HUMAN
pepwheel	swissprot:VATA_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VATA_HUMAN
pepwindow	swissprot:VATA_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VATA_HUMAN
sigcleave	swissprot:VATA_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VATA_HUMAN
## Database	ID	URL or Descriptions
# CAUTION	Is shorter at the C-terminus than its mouse ortholog due to the presence of a premature stop codon. As a consequence, it lacks the fourth transmembrane span. {ECO	0000305}.
# Ensembl	ENST00000372617	ENSP00000361700; ENSG00000188828
# ExpressionAtlas	Q5JXX5	baseline and differential
# FUNCTION	GLRA4_HUMAN	Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. {ECO 0000250|UniProtKB Q61603}. 
# GO_component	GO:0005887	integral component of plasma membrane; IEA:Ensembl.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030425	dendrite; IEA:UniProtKB-SubCell.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0043204	perikaryon; IEA:UniProtKB-SubCell.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0016594	glycine binding; IEA:InterPro.
# GO_function	GO:0016934	extracellular-glycine-gated chloride channel activity; IEA:Ensembl.
# GO_function	GO:0022824	transmitter-gated ion channel activity; IEA:InterPro.
# GO_process	GO:0007218	neuropeptide signaling pathway; IBA:GO_Central.
# GO_process	GO:0043200	response to amino acid; IBA:GO_Central.
# GO_process	GO:0060012	synaptic transmission, glycinergic; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# Gene3D	2.70.170.10	-; 1.
# HGNC	HGNC:31715	GLRA4
# InterPro	IPR006028	GABAA/Glycine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR008127	Glycine_rcpt_A
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# KEGG_Brite	ko04040	Ion channels
# MISCELLANEOUS	The alpha subunit binds strychnine. {ECO:0000250|UniProtKB	Q61603}. 
# Organism	GLRA4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR18945	PTHR18945
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00253	GABAARECEPTR
# PRINTS	PR01673	GLYRALPHA
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-975298	Ligand-gated ion channel transport
# RecName	GLRA4_HUMAN	Glycine receptor subunit alpha-4
# RefSeq	NP_001019623	NM_001024452.2
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA4 sub- subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	GLRA4_HUMAN	Cell junction, synapse, postsynaptic cell membrane {ECO 0000250|UniProtKB Q61603}; Multi-pass membrane protein {ECO 0000250|UniProtKB Q61603}. Cell junction, synapse {ECO 0000250|UniProtKB Q61603}. Perikaryon {ECO 0000250|UniProtKB Q61603}. Cell projection, dendrite {ECO 0000250|UniProtKB Q61603}. Cell membrane {ECO 0000250|UniProtKB Q61603}; Multi-pass membrane protein {ECO 0000250|UniProtKB Q61603}. 
# SUBUNIT	Homopentamer (in vitro). Pentamer composed of alpha and beta subunits. {ECO:0000250, ECO	0000250|UniProtKB:Q61603}. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TIGRFAMs	TIGR00860	LIC
# TISSUE SPECIFICITY	Detected in trachea smooth muscle. {ECO:0000269|PubMed	21282206}. 
# UCSC	uc011mse	human
# eggNOG	ENOG410XPWH	LUCA
# eggNOG	KOG3643	Eukaryota
BLAST	swissprot:GLRA4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GLRA4_HUMAN
BioCyc	ZFISH:G66-31440-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31440-MONOMER
COXPRESdb	441509	http://coxpresdb.jp/data/gene/441509.shtml
CleanEx	HS_GLRA4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GLRA4
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1096/fj.10-170530	http://dx.doi.org/10.1096/fj.10-170530
EMBL	AL049610	http://www.ebi.ac.uk/ena/data/view/AL049610
EMBL	AL049610	http://www.ebi.ac.uk/ena/data/view/AL049610
EMBL	Z93848	http://www.ebi.ac.uk/ena/data/view/Z93848
EMBL	Z93848	http://www.ebi.ac.uk/ena/data/view/Z93848
Ensembl	ENST00000372617	http://www.ensembl.org/id/ENST00000372617
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0043204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043204
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0016594	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016594
GO_function	GO:0016934	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016934
GO_function	GO:0022824	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022824
GO_process	GO:0007218	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007218
GO_process	GO:0043200	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043200
GO_process	GO:0060012	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060012
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	GLRA4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GLRA4
GeneID	441509	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=441509
GeneTree	ENSGT00760000118821	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118821
HGNC	HGNC:31715	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:31715
HOGENOM	HOG000231336	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231336&db=HOGENOM6
HOVERGEN	HBG051707	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051707&db=HOVERGEN
HPA	HPA044759	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA044759
InParanoid	Q5JXX5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q5JXX5
InterPro	IPR006028	http://www.ebi.ac.uk/interpro/entry/IPR006028
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR008127	http://www.ebi.ac.uk/interpro/entry/IPR008127
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
Jabion	441509	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=441509
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:441509	http://www.genome.jp/dbget-bin/www_bget?hsa:441509
KEGG_Orthology	KO:K05271	http://www.genome.jp/dbget-bin/www_bget?KO:K05271
OMA	ARDGGPM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ARDGGPM
OrthoDB	EOG091G0805	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0805
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00253	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00253
PRINTS	PR01673	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01673
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:GLRA4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GLRA4_HUMAN
PSORT-B	swissprot:GLRA4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GLRA4_HUMAN
PSORT2	swissprot:GLRA4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GLRA4_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA142671731	http://www.pharmgkb.org/do/serve?objId=PA142671731&objCls=Gene
Phobius	swissprot:GLRA4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GLRA4_HUMAN
PhylomeDB	Q5JXX5	http://phylomedb.org/?seqid=Q5JXX5
ProteinModelPortal	Q5JXX5	http://www.proteinmodelportal.org/query/uniprot/Q5JXX5
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	21282206	http://www.ncbi.nlm.nih.gov/pubmed/21282206
Reactome	R-HSA-975298	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-975298
RefSeq	NP_001019623	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001019623
SMR	Q5JXX5	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q5JXX5
STRING	9606.ENSP00000361700	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000361700&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc011mse	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc011mse&org=rat
UniGene	Hs.533289	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.533289
UniProtKB	GLRA4_HUMAN	http://www.uniprot.org/uniprot/GLRA4_HUMAN
UniProtKB-AC	Q5JXX5	http://www.uniprot.org/uniprot/Q5JXX5
charge	swissprot:GLRA4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GLRA4_HUMAN
eggNOG	ENOG410XPWH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPWH
eggNOG	KOG3643	http://eggnogapi.embl.de/nog_data/html/tree/KOG3643
epestfind	swissprot:GLRA4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GLRA4_HUMAN
garnier	swissprot:GLRA4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GLRA4_HUMAN
helixturnhelix	swissprot:GLRA4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLRA4_HUMAN
hmoment	swissprot:GLRA4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GLRA4_HUMAN
iep	swissprot:GLRA4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GLRA4_HUMAN
inforesidue	swissprot:GLRA4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GLRA4_HUMAN
neXtProt	NX_Q5JXX5	http://www.nextprot.org/db/entry/NX_Q5JXX5
octanol	swissprot:GLRA4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GLRA4_HUMAN
pepcoil	swissprot:GLRA4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GLRA4_HUMAN
pepdigest	swissprot:GLRA4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GLRA4_HUMAN
pepinfo	swissprot:GLRA4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GLRA4_HUMAN
pepnet	swissprot:GLRA4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GLRA4_HUMAN
pepstats	swissprot:GLRA4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GLRA4_HUMAN
pepwheel	swissprot:GLRA4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GLRA4_HUMAN
pepwindow	swissprot:GLRA4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GLRA4_HUMAN
sigcleave	swissprot:GLRA4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GLRA4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SL9A1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P19634-1; Sequence=Displayed; Name=2; IsoId=P19634-2; Sequence=VSP_022101, VSP_022102; Note=No experimental confirmation available.; 
# AltName	SL9A1_HUMAN	APNH
# AltName	SL9A1_HUMAN	Na(+)/H(+) antiporter, amiloride-sensitive
# AltName	SL9A1_HUMAN	Na(+)/H(+) exchanger 1
# AltName	SL9A1_HUMAN	Solute carrier family 9 member 1
# BIOPHYSICOCHEMICAL PROPERTIES	pH dependence	 Fully active at acidic pHs, the antiporter is virtually turned off at neutral pH.; 
# BioGrid	112438	37
# CAUTION	Although PubMed:12809501 report that CHP1 and TESC bind to SLC9A1 at different sites, studies with rat SLC9A1 show that they bind at the same C-terminal site. {ECO	0000305}.
# CAUTION	Although PubMed:12809501 report that TESC-binding results in a decrease in activity, studies with rat SLC9A1 show that TESC- binding results in the maturation and accumulation of SLC9A1 at the cell surface. {ECO	0000305}. 
# CAUTION	The region between transmembrane regions M4 and M5 and between M6 and M7 (also termed intracellular loops IL2 and IL4, respectively) seem to be localized at least in part in the membrane. The hydrophobic region H10 is proposed to be located within the membrane. {ECO	0000305}. 
# CCDS	CCDS295	-. [P19634-1]
# ChiTaRS	SLC9A1	human
# DISEASE	SL9A1_HUMAN	Lichtenstein-Knorr syndrome (LIKNS) [MIM 616291]  An autosomal recessive neurologic disorder characterized by progressive cerebellar ataxia and severe progressive sensorineural hearing loss. {ECO 0000269|PubMed 25205112}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00594	Amiloride
# Ensembl	ENST00000263980	ENSP00000263980; ENSG00000090020. [P19634-1]
# Ensembl	ENST00000374086	ENSP00000363199; ENSG00000090020. [P19634-2]
# ExpressionAtlas	P19634	baseline and differential
# FUNCTION	SL9A1_HUMAN	Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. {ECO 0000269|PubMed 11350981, ECO 0000269|PubMed 15035633, ECO 0000269|PubMed 8901634}. 
# GO_component	GO:0005654	nucleoplasm; IDA:HPA.
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005739	mitochondrion; IEA:Ensembl.
# GO_component	GO:0005783	endoplasmic reticulum; ISS:UniProtKB.
# GO_component	GO:0005789	endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0005925	focal adhesion; IDA:UniProtKB.
# GO_component	GO:0009986	cell surface; IEA:Ensembl.
# GO_component	GO:0014704	intercalated disc; IEA:Ensembl.
# GO_component	GO:0016021	integral component of membrane; TAS:UniProtKB.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:Ensembl.
# GO_component	GO:0016324	apical plasma membrane; IEA:Ensembl.
# GO_component	GO:0030027	lamellipodium; TAS:BHF-UCL.
# GO_component	GO:0030315	T-tubule; IEA:Ensembl.
# GO_component	GO:0045121	membrane raft; IDA:BHF-UCL.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IEA:Ensembl.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_component	GO:0090533	cation-transporting ATPase complex; IDA:BHF-UCL.
# GO_function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding; TAS:BHF-UCL.
# GO_function	GO:0030346	protein phosphatase 2B binding; IDA:BHF-UCL.
# GO_function	GO:0030674	protein binding, bridging; TAS:BHF-UCL.
# GO_function	GO:0032947	protein complex scaffold; TAS:BHF-UCL.
# GO_function	GO:0048306	calcium-dependent protein binding; IDA:UniProtKB.
# GO_function	SL9A1_HUMAN	GO 0015299 solute proton antiporter activity; TAS UniProtKB.
# GO_function	SL9A1_HUMAN	GO 0015385 sodium proton antiporter activity; IDA UniProtKB.
# GO_function	SL9A1_HUMAN	GO 0015386 potassium proton antiporter activity; IBA GO_Central.
# GO_function	SL9A1_HUMAN	GO 0086040 sodium proton antiporter activity involved in regulation of cardiac muscle cell membrane potential; TAS BHF-UCL.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006883	cellular sodium ion homeostasis; IDA:BHF-UCL.
# GO_process	GO:0006885	regulation of pH; IDA:UniProtKB.
# GO_process	GO:0010447	response to acidic pH; IDA:UniProtKB.
# GO_process	GO:0010613	positive regulation of cardiac muscle hypertrophy; IMP:BHF-UCL.
# GO_process	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling; IMP:BHF-UCL.
# GO_process	GO:0016049	cell growth; IEA:Ensembl.
# GO_process	GO:0016477	cell migration; TAS:BHF-UCL.
# GO_process	GO:0030011	maintenance of cell polarity; TAS:BHF-UCL.
# GO_process	GO:0030214	hyaluronan catabolic process; TAS:Reactome.
# GO_process	GO:0030307	positive regulation of cell growth; IEA:Ensembl.
# GO_process	GO:0032869	cellular response to insulin stimulus; IEA:Ensembl.
# GO_process	GO:0035794	positive regulation of mitochondrial membrane permeability; IEA:Ensembl.
# GO_process	GO:0035994	response to muscle stretch; IMP:BHF-UCL.
# GO_process	GO:0042493	response to drug; IEA:Ensembl.
# GO_process	GO:0043065	positive regulation of apoptotic process; IEA:Ensembl.
# GO_process	GO:0043066	negative regulation of apoptotic process; IEA:Ensembl.
# GO_process	GO:0045760	positive regulation of action potential; IEA:Ensembl.
# GO_process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
# GO_process	GO:0051259	protein oligomerization; ISS:UniProtKB.
# GO_process	GO:0051453	regulation of intracellular pH; IDA:UniProtKB.
# GO_process	GO:0051492	regulation of stress fiber assembly; TAS:BHF-UCL.
# GO_process	GO:0051533	positive regulation of NFAT protein import into nucleus; IDA:BHF-UCL.
# GO_process	GO:0051893	regulation of focal adhesion assembly; TAS:BHF-UCL.
# GO_process	GO:0051930	regulation of sensory perception of pain; IEA:Ensembl.
# GO_process	GO:0055007	cardiac muscle cell differentiation; IEA:Ensembl.
# GO_process	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade; IDA:BHF-UCL.
# GO_process	GO:0070997	neuron death; IEA:Ensembl.
# GO_process	GO:0071236	cellular response to antibiotic; IEA:Ensembl.
# GO_process	GO:0071257	cellular response to electrical stimulus; IEA:Ensembl.
# GO_process	GO:0071260	cellular response to mechanical stimulus; TAS:BHF-UCL.
# GO_process	GO:0071436	sodium ion export; ISS:UniProtKB.
# GO_process	GO:0071456	cellular response to hypoxia; IEA:Ensembl.
# GO_process	GO:0071468	cellular response to acidic pH; ISS:UniProtKB.
# GO_process	GO:0071805	potassium ion transmembrane transport; IBA:GO_Central.
# GO_process	GO:0071872	cellular response to epinephrine stimulus; IMP:BHF-UCL.
# GO_process	GO:0086003	cardiac muscle cell contraction; IEA:Ensembl.
# GO_process	GO:0086036	regulation of cardiac muscle cell membrane potential; TAS:BHF-UCL.
# GO_process	GO:0086092	regulation of the force of heart contraction by cardiac conduction; IMP:BHF-UCL.
# GO_process	GO:0098719	sodium ion import across plasma membrane; IDA:BHF-UCL.
# GO_process	GO:0098735	positive regulation of the force of heart contraction; IMP:BHF-UCL.
# GO_process	GO:1902600	hydrogen ion transmembrane transport; IDA:BHF-UCL.
# GO_process	SL9A1_HUMAN	GO 1903281 positive regulation of calcium sodium antiporter activity; IMP BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0005198	structural molecule activity
# GOslim_function	GO:0008289	lipid binding
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0030674	protein binding, bridging
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007005	mitochondrion organization
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0008219	cell death
# GOslim_process	GO:0009056	catabolic process
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0040007	growth
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048870	cell motility
# GOslim_process	GO:0055085	transmembrane transport
# GOslim_process	GO:0061024	membrane organization
# Genevisible	P19634	HS
# HGNC	HGNC:11071	SLC9A1
# IntAct	P19634	13
# InterPro	IPR001970	Na/H_exchanger_1
# InterPro	IPR004709	NaH_exchanger
# InterPro	IPR006153	Cation/H_exchanger
# InterPro	IPR018422	Cation/H_exchanger_CPA1
# InterPro	IPR032103	NHE_CaM-bd
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko04810	Regulation of actin cytoskeleton
# KEGG_Pathway	ko04970	Salivary secretion
# KEGG_Pathway	ko04971	Gastric acid secretion
# KEGG_Pathway	ko04972	Pancreatic secretion
# KEGG_Pathway	ko04976	Bile secretion
# MIM	107310	gene
# MIM	616291	phenotype
# MISCELLANEOUS	SL9A1_HUMAN	Inhibited by amiloride and 5-amino-substituted derivatives and activated in a cooperative fashion by intracellular H(+). In quiescent cells upon growth factor stimulation, the apparent affinity for internal H(+) is increased, resulting in a persistent rise in cytoplasmic pH. 
# Organism	SL9A1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10110	PTHR10110
# PANTHER	PTHR10110:SF59	PTHR10110:SF59
# PDB	1Y4E	NMR; -; A=155-180
# PDB	2BEC	X-ray; 2.70 A; B=503-545
# PDB	2E30	NMR; -; B=503-545
# PDB	2HTG	NMR; -; A=250-274
# PDB	2KBV	NMR; -; A=447-472
# PDB	2L0E	NMR; -; A=226-250
# PDB	2MDF	NMR; -; A=226-274
# PDB	2YGG	X-ray; 2.23 A; A=622-689
# PIR	I57487	I57487
# PRINTS	PR01084	NAHEXCHNGR
# PRINTS	PR01085	NAHEXCHNGR1
# PTM	SL9A1_HUMAN	O-glycosylated. {ECO 0000269|PubMed 8068684}. 
# PTM	SL9A1_HUMAN	Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is reduced by CHP1 (By similarity). {ECO 0000250}. 
# Pfam	PF00999	Na_H_Exchanger
# Pfam	PF16644	NEXCaM_BD
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-2160916	Hyaluronan uptake and degradation
# Reactome	R-HSA-425986	Sodium/Proton exchangers
# RecName	SL9A1_HUMAN	Sodium/hydrogen exchanger 1
# RefSeq	NP_003038	NM_003047.4. [P19634-1]
# SIMILARITY	Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	SL9A1_HUMAN	Membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Cell membrane; Multi-pass membrane protein. Note=Colocalizes with CHP1 at the reticulum endoplasmic (By similarity). Colocalizes with CHP1 and CHP2 at the plasma membrane. {ECO 0000250}. 
# SUBUNIT	SL9A1_HUMAN	Oligomer (By similarity). Interacts with calmodulin and TESC. Interacts (via the juxtamembrane region of the cytoplasmic C-terminal domain) with CHP1; the interaction occurs at the plasma membrane in a calcium-dependent manner. Interacts with CHP2; the interaction occurs in a calcium-dependent manner. {ECO 0000250, ECO 0000269|PubMed 11350981, ECO 0000269|PubMed 11696366, ECO 0000269|PubMed 12226101, ECO 0000269|PubMed 12809501, ECO 0000269|PubMed 15035633, ECO 0000269|PubMed 16710297, ECO 0000269|PubMed 17050540, ECO 0000269|PubMed 21392185, ECO 0000269|PubMed 8901634, ECO 0000269|PubMed 8967452}. 
# TCDB	2.A.36.1.13:the monovalent cation	proton antiporter-1 (cpa1) family
# TIGRFAMs	TIGR00840	b_cpa1
# TISSUE SPECIFICITY	SL9A1_HUMAN	Kidney and intestine. 
# UCSC	uc001bnm	human. [P19634-1]
# eggNOG	COG0025	LUCA
# eggNOG	KOG1966	Eukaryota
BLAST	swissprot:SL9A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SL9A1_HUMAN
BioCyc	ZFISH:ENSG00000090020-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000090020-MONOMER
COXPRESdb	6548	http://coxpresdb.jp/data/gene/6548.shtml
CleanEx	HS_SLC9A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC9A1
DOI	10.1007/BF00936442	http://dx.doi.org/10.1007/BF00936442
DOI	10.1016/0092-8674(89)90901-X	http://dx.doi.org/10.1016/0092-8674(89)90901-X
DOI	10.1016/S0014-5793(01)02986-6	http://dx.doi.org/10.1016/S0014-5793(01)02986-6
DOI	10.1016/S0165-4608(99)00246-0	http://dx.doi.org/10.1016/S0165-4608(99)00246-0
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/bi00200a030	http://dx.doi.org/10.1021/bi00200a030
DOI	10.1021/bi027143d	http://dx.doi.org/10.1021/bi027143d
DOI	10.1021/bi0360004	http://dx.doi.org/10.1021/bi0360004
DOI	10.1021/pr0704130	http://dx.doi.org/10.1021/pr0704130
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/sj.emboj.7601145	http://dx.doi.org/10.1038/sj.emboj.7601145
DOI	10.1042/BJ20030884	http://dx.doi.org/10.1042/BJ20030884
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.93.22.12631	http://dx.doi.org/10.1073/pnas.93.22.12631
DOI	10.1074/jbc.275.11.7942	http://dx.doi.org/10.1074/jbc.275.11.7942
DOI	10.1074/jbc.M100296200	http://dx.doi.org/10.1074/jbc.M100296200
DOI	10.1074/jbc.M208313200	http://dx.doi.org/10.1074/jbc.M208313200
DOI	10.1074/jbc.M409608200	http://dx.doi.org/10.1074/jbc.M409608200
DOI	10.1074/jbc.M604092200	http://dx.doi.org/10.1074/jbc.M604092200
DOI	10.1093/hmg/ddu461	http://dx.doi.org/10.1093/hmg/ddu461
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1107/S1744309105030836	http://dx.doi.org/10.1107/S1744309105030836
DOI	10.1111/j.1365-2443.2011.01497.x	http://dx.doi.org/10.1111/j.1365-2443.2011.01497.x
DOI	10.1126/science.1140321	http://dx.doi.org/10.1126/science.1140321
DOI	10.1126/science.2154036	http://dx.doi.org/10.1126/science.2154036
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DrugBank	DB00594	http://www.drugbank.ca/drugs/DB00594
EMBL	AF141350	http://www.ebi.ac.uk/ena/data/view/AF141350
EMBL	AF141351	http://www.ebi.ac.uk/ena/data/view/AF141351
EMBL	AF141352	http://www.ebi.ac.uk/ena/data/view/AF141352
EMBL	AF141353	http://www.ebi.ac.uk/ena/data/view/AF141353
EMBL	AF141354	http://www.ebi.ac.uk/ena/data/view/AF141354
EMBL	AF141355	http://www.ebi.ac.uk/ena/data/view/AF141355
EMBL	AF141356	http://www.ebi.ac.uk/ena/data/view/AF141356
EMBL	AF141357	http://www.ebi.ac.uk/ena/data/view/AF141357
EMBL	AF141358	http://www.ebi.ac.uk/ena/data/view/AF141358
EMBL	AF141359	http://www.ebi.ac.uk/ena/data/view/AF141359
EMBL	AF146430	http://www.ebi.ac.uk/ena/data/view/AF146430
EMBL	AF146431	http://www.ebi.ac.uk/ena/data/view/AF146431
EMBL	AF146432	http://www.ebi.ac.uk/ena/data/view/AF146432
EMBL	AF146433	http://www.ebi.ac.uk/ena/data/view/AF146433
EMBL	AF146434	http://www.ebi.ac.uk/ena/data/view/AF146434
EMBL	AF146435	http://www.ebi.ac.uk/ena/data/view/AF146435
EMBL	AF146436	http://www.ebi.ac.uk/ena/data/view/AF146436
EMBL	AF146437	http://www.ebi.ac.uk/ena/data/view/AF146437
EMBL	AF146438	http://www.ebi.ac.uk/ena/data/view/AF146438
EMBL	AF146439	http://www.ebi.ac.uk/ena/data/view/AF146439
EMBL	AL137860	http://www.ebi.ac.uk/ena/data/view/AL137860
EMBL	AL137860	http://www.ebi.ac.uk/ena/data/view/AL137860
EMBL	AL137860	http://www.ebi.ac.uk/ena/data/view/AL137860
EMBL	AL137860	http://www.ebi.ac.uk/ena/data/view/AL137860
EMBL	AL590640	http://www.ebi.ac.uk/ena/data/view/AL590640
EMBL	AL590640	http://www.ebi.ac.uk/ena/data/view/AL590640
EMBL	AL590640	http://www.ebi.ac.uk/ena/data/view/AL590640
EMBL	AL590640	http://www.ebi.ac.uk/ena/data/view/AL590640
EMBL	BC012121	http://www.ebi.ac.uk/ena/data/view/BC012121
EMBL	CH471059	http://www.ebi.ac.uk/ena/data/view/CH471059
EMBL	CH471059	http://www.ebi.ac.uk/ena/data/view/CH471059
EMBL	M81768	http://www.ebi.ac.uk/ena/data/view/M81768
EMBL	S68616	http://www.ebi.ac.uk/ena/data/view/S68616
Ensembl	ENST00000263980	http://www.ensembl.org/id/ENST00000263980
Ensembl	ENST00000374086	http://www.ensembl.org/id/ENST00000374086
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005925	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005925
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0014704	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014704
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0030027	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030027
GO_component	GO:0030315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030315
GO_component	GO:0045121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045121
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_component	GO:0090533	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090533
GO_function	GO:0005546	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005546
GO_function	GO:0015299	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015299
GO_function	GO:0015385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015385
GO_function	GO:0015386	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015386
GO_function	GO:0030346	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030346
GO_function	GO:0030674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030674
GO_function	GO:0032947	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032947
GO_function	GO:0048306	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048306
GO_function	GO:0086040	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086040
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006883	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006883
GO_process	GO:0006885	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006885
GO_process	GO:0010447	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010447
GO_process	GO:0010613	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010613
GO_process	GO:0010882	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010882
GO_process	GO:0016049	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016049
GO_process	GO:0016477	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016477
GO_process	GO:0030011	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030011
GO_process	GO:0030214	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030214
GO_process	GO:0030307	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030307
GO_process	GO:0032869	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032869
GO_process	GO:0035794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035794
GO_process	GO:0035994	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035994
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0043065	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043065
GO_process	GO:0043066	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043066
GO_process	GO:0045760	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045760
GO_process	GO:0045944	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045944
GO_process	GO:0051259	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051259
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GO_process	GO:0051492	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051492
GO_process	GO:0051533	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051533
GO_process	GO:0051893	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051893
GO_process	GO:0051930	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051930
GO_process	GO:0055007	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055007
GO_process	GO:0070886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070886
GO_process	GO:0070997	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070997
GO_process	GO:0071236	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071236
GO_process	GO:0071257	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071257
GO_process	GO:0071260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071260
GO_process	GO:0071436	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071436
GO_process	GO:0071456	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071456
GO_process	GO:0071468	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071468
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GO_process	GO:0071872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071872
GO_process	GO:0086003	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086003
GO_process	GO:0086036	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086036
GO_process	GO:0086092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086092
GO_process	GO:0098719	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098719
GO_process	GO:0098735	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098735
GO_process	GO:1902600	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902600
GO_process	GO:1903281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903281
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0005198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198
GOslim_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0030674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030674
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007005
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0008219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219
GOslim_process	GO:0009056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0040007	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040007
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
GeneCards	SLC9A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC9A1
GeneID	6548	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6548
GeneTree	ENSGT00760000119074	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119074
HGNC	HGNC:11071	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11071
HOGENOM	HOG000247044	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000247044&db=HOGENOM6
HOVERGEN	HBG052615	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052615&db=HOVERGEN
HPA	CAB022371	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB022371
HPA	HPA048532	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA048532
HPA	HPA052891	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA052891
InParanoid	P19634	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P19634
IntAct	P19634	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P19634*
InterPro	IPR001970	http://www.ebi.ac.uk/interpro/entry/IPR001970
InterPro	IPR004709	http://www.ebi.ac.uk/interpro/entry/IPR004709
InterPro	IPR006153	http://www.ebi.ac.uk/interpro/entry/IPR006153
InterPro	IPR018422	http://www.ebi.ac.uk/interpro/entry/IPR018422
InterPro	IPR032103	http://www.ebi.ac.uk/interpro/entry/IPR032103
Jabion	6548	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6548
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6548	http://www.genome.jp/dbget-bin/www_bget?hsa:6548
KEGG_Orthology	KO:K05742	http://www.genome.jp/dbget-bin/www_bget?KO:K05742
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko04810	http://www.genome.jp/kegg-bin/show_pathway?ko04810
KEGG_Pathway	ko04970	http://www.genome.jp/kegg-bin/show_pathway?ko04970
KEGG_Pathway	ko04971	http://www.genome.jp/kegg-bin/show_pathway?ko04971
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
MIM	107310	http://www.ncbi.nlm.nih.gov/omim/107310
MIM	616291	http://www.ncbi.nlm.nih.gov/omim/616291
MINT	MINT-194742	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-194742
OMA	KPIMIST	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KPIMIST
OrthoDB	EOG091G02Q0	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02Q0
PANTHER	PTHR10110	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10110
PANTHER	PTHR10110:SF59	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10110:SF59
PDB	1Y4E	http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y4E
PDB	2BEC	http://www.ebi.ac.uk/pdbe-srv/view/entry/2BEC
PDB	2E30	http://www.ebi.ac.uk/pdbe-srv/view/entry/2E30
PDB	2HTG	http://www.ebi.ac.uk/pdbe-srv/view/entry/2HTG
PDB	2KBV	http://www.ebi.ac.uk/pdbe-srv/view/entry/2KBV
PDB	2L0E	http://www.ebi.ac.uk/pdbe-srv/view/entry/2L0E
PDB	2MDF	http://www.ebi.ac.uk/pdbe-srv/view/entry/2MDF
PDB	2YGG	http://www.ebi.ac.uk/pdbe-srv/view/entry/2YGG
PDBsum	1Y4E	http://www.ebi.ac.uk/pdbsum/1Y4E
PDBsum	2BEC	http://www.ebi.ac.uk/pdbsum/2BEC
PDBsum	2E30	http://www.ebi.ac.uk/pdbsum/2E30
PDBsum	2HTG	http://www.ebi.ac.uk/pdbsum/2HTG
PDBsum	2KBV	http://www.ebi.ac.uk/pdbsum/2KBV
PDBsum	2L0E	http://www.ebi.ac.uk/pdbsum/2L0E
PDBsum	2MDF	http://www.ebi.ac.uk/pdbsum/2MDF
PDBsum	2YGG	http://www.ebi.ac.uk/pdbsum/2YGG
PRINTS	PR01084	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01084
PRINTS	PR01085	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01085
PSORT	swissprot:SL9A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SL9A1_HUMAN
PSORT-B	swissprot:SL9A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SL9A1_HUMAN
PSORT2	swissprot:SL9A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SL9A1_HUMAN
Pfam	PF00999	http://pfam.xfam.org/family/PF00999
Pfam	PF16644	http://pfam.xfam.org/family/PF16644
PharmGKB	PA35928	http://www.pharmgkb.org/do/serve?objId=PA35928&objCls=Gene
Phobius	swissprot:SL9A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SL9A1_HUMAN
PhylomeDB	P19634	http://phylomedb.org/?seqid=P19634
ProteinModelPortal	P19634	http://www.proteinmodelportal.org/query/uniprot/P19634
PubMed	10713111	http://www.ncbi.nlm.nih.gov/pubmed/10713111
PubMed	10913675	http://www.ncbi.nlm.nih.gov/pubmed/10913675
PubMed	11350981	http://www.ncbi.nlm.nih.gov/pubmed/11350981
PubMed	11696366	http://www.ncbi.nlm.nih.gov/pubmed/11696366
PubMed	12226101	http://www.ncbi.nlm.nih.gov/pubmed/12226101
PubMed	12809501	http://www.ncbi.nlm.nih.gov/pubmed/12809501
PubMed	14680478	http://www.ncbi.nlm.nih.gov/pubmed/14680478
PubMed	15035633	http://www.ncbi.nlm.nih.gov/pubmed/15035633
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15677483	http://www.ncbi.nlm.nih.gov/pubmed/15677483
PubMed	16511206	http://www.ncbi.nlm.nih.gov/pubmed/16511206
PubMed	16710297	http://www.ncbi.nlm.nih.gov/pubmed/16710297
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17050540	http://www.ncbi.nlm.nih.gov/pubmed/17050540
PubMed	1712287	http://www.ncbi.nlm.nih.gov/pubmed/1712287
PubMed	17525332	http://www.ncbi.nlm.nih.gov/pubmed/17525332
PubMed	18088087	http://www.ncbi.nlm.nih.gov/pubmed/18088087
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21392185	http://www.ncbi.nlm.nih.gov/pubmed/21392185
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	2154036	http://www.ncbi.nlm.nih.gov/pubmed/2154036
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25205112	http://www.ncbi.nlm.nih.gov/pubmed/25205112
PubMed	2536298	http://www.ncbi.nlm.nih.gov/pubmed/2536298
PubMed	8068684	http://www.ncbi.nlm.nih.gov/pubmed/8068684
PubMed	8283968	http://www.ncbi.nlm.nih.gov/pubmed/8283968
PubMed	8901634	http://www.ncbi.nlm.nih.gov/pubmed/8901634
PubMed	8967452	http://www.ncbi.nlm.nih.gov/pubmed/8967452
PubMed	9688597	http://www.ncbi.nlm.nih.gov/pubmed/9688597
Reactome	R-HSA-2160916	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2160916
Reactome	R-HSA-425986	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425986
RefSeq	NP_003038	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003038
SMR	P19634	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P19634
STRING	9606.ENSP00000263980	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000263980&targetmode=cogs
TCDB	2.A.36.1.13	http://www.tcdb.org/search/result.php?tc=2.A.36.1.13
TIGRFAMs	TIGR00840	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00840
UCSC	uc001bnm	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001bnm&org=rat
UniGene	Hs.469116	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.469116
UniProtKB	SL9A1_HUMAN	http://www.uniprot.org/uniprot/SL9A1_HUMAN
UniProtKB-AC	P19634	http://www.uniprot.org/uniprot/P19634
charge	swissprot:SL9A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SL9A1_HUMAN
eggNOG	COG0025	http://eggnogapi.embl.de/nog_data/html/tree/COG0025
eggNOG	KOG1966	http://eggnogapi.embl.de/nog_data/html/tree/KOG1966
epestfind	swissprot:SL9A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SL9A1_HUMAN
garnier	swissprot:SL9A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SL9A1_HUMAN
helixturnhelix	swissprot:SL9A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SL9A1_HUMAN
hmoment	swissprot:SL9A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SL9A1_HUMAN
iep	swissprot:SL9A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SL9A1_HUMAN
inforesidue	swissprot:SL9A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SL9A1_HUMAN
neXtProt	NX_P19634	http://www.nextprot.org/db/entry/NX_P19634
octanol	swissprot:SL9A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SL9A1_HUMAN
pepcoil	swissprot:SL9A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SL9A1_HUMAN
pepdigest	swissprot:SL9A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SL9A1_HUMAN
pepinfo	swissprot:SL9A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SL9A1_HUMAN
pepnet	swissprot:SL9A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SL9A1_HUMAN
pepstats	swissprot:SL9A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SL9A1_HUMAN
pepwheel	swissprot:SL9A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SL9A1_HUMAN
pepwindow	swissprot:SL9A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SL9A1_HUMAN
sigcleave	swissprot:SL9A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SL9A1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNQ2_HUMAN	Event=Alternative splicing; Named isoforms=6; Comment=Additional isoforms seem to exist.; Name=1; IsoId=O43526-1; Sequence=Displayed; Name=2; IsoId=O43526-2; Sequence=VSP_000988; Name=3; IsoId=O43526-3; Sequence=VSP_000985, VSP_000988; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=4; IsoId=O43526-4; Sequence=VSP_000989, VSP_000990; Name=5; IsoId=O43526-5; Sequence=VSP_000984, VSP_000988; Name=6; Synonyms=HNSPC; IsoId=O43526-6; Sequence=VSP_000986, VSP_000987; 
# AltName	KCNQ2_HUMAN	KQT-like 2
# AltName	KCNQ2_HUMAN	Neuroblastoma-specific potassium channel subunit alpha KvLQT2
# AltName	KCNQ2_HUMAN	Voltage-gated potassium channel subunit Kv7.2
# BioGrid	109986	6
# CCDS	CCDS13518	-. [O43526-3]
# CCDS	CCDS13519	-. [O43526-2]
# CCDS	CCDS13520	-. [O43526-1]
# CCDS	CCDS13521	-. [O43526-6]
# CCDS	CCDS46629	-. [O43526-4]
# ChiTaRS	KCNQ2	human
# DISEASE	KCNQ2_HUMAN	Epileptic encephalopathy, early infantile, 7 (EIEE7) [MIM 613720]  An autosomal dominant seizure disorder characterized by infantile onset of refractory seizures with resultant delayed neurologic development and persistent neurologic abnormalities. {ECO 0000269|PubMed 12742592, ECO 0000269|PubMed 15249611}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	KCNQ2_HUMAN	Seizures, benign familial neonatal 1 (BFNS1) [MIM 121200]  A disorder characterized by clusters of seizures occurring in the first days of life. Most patients have spontaneous remission by 12 months of age and show normal psychomotor development. Some rare cases manifest an atypical severe phenotype associated with epileptic encephalopathy and psychomotor retardation. The disorder is distinguished from benign familial infantile seizures by an earlier age at onset. In some patients, neonatal convulsions are followed later in life by myokymia, a benign condition characterized by spontaneous involuntary contractions of skeletal muscles fiber groups that can be observed as vermiform movement of the overlying skin. Electromyography typically shows continuous motor unit activity with spontaneous oligo- and multiplet-discharges of high intraburst frequency (myokymic discharges). Some patients may have isolated myokymia. {ECO 0000269|PubMed 11175290, ECO 0000269|PubMed 11572947, ECO 0000269|PubMed 14534157, ECO 0000269|PubMed 15249611, ECO 0000269|PubMed 9425895}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	KCNQ2_HUMAN	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. {ECO 0000250}. 
# DrugBank	DB00321	Amitriptyline
# DrugBank	DB00586	Diclofenac
# DrugBank	DB00939	Meclofenamic acid
# DrugBank	DB04953	Ezogabine
# Ensembl	ENST00000344425	ENSP00000345523; ENSG00000075043. [O43526-6]
# Ensembl	ENST00000344462	ENSP00000339611; ENSG00000075043. [O43526-4]
# Ensembl	ENST00000359125	ENSP00000352035; ENSG00000075043. [O43526-1]
# Ensembl	ENST00000360480	ENSP00000353668; ENSG00000075043. [O43526-3]
# Ensembl	ENST00000626839	ENSP00000486706; ENSG00000075043. [O43526-2]
# ExpressionAtlas	O43526	baseline and differential
# FUNCTION	KCNQ2_HUMAN	Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine. Muscarinic agonist oxotremorine-M strongly suppress KCNQ2/KCNQ3 current in cells in which cloned KCNQ2/KCNQ3 channels were coexpressed with M1 muscarinic receptors. 
# GO_component	GO:0005886	plasma membrane; ISS:BHF-UCL.
# GO_component	GO:0008076	voltage-gated potassium channel complex; TAS:ProtInc.
# GO_component	GO:0033268	node of Ranvier; ISS:BHF-UCL.
# GO_component	GO:0043194	axon initial segment; ISS:BHF-UCL.
# GO_function	GO:0005249	voltage-gated potassium channel activity; TAS:ProtInc.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; IBA:GO_Central.
# GO_function	GO:0005267	potassium channel activity; TAS:ProtInc.
# GO_function	GO:0030506	ankyrin binding; IPI:BHF-UCL.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:ProtInc.
# GO_process	GO:0007399	nervous system development; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0008092	cytoskeletal protein binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0048856	anatomical structure development
# Genevisible	O43526	HS
# HGNC	HGNC:6296	KCNQ2
# InterPro	IPR003937	K_chnl_volt-dep_KCNQ
# InterPro	IPR003947	K_chnl_volt-dep_KCNQ2
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR013821	K_chnl_volt-dep_KCNQ_C
# InterPro	IPR020969	Ankyrin-G_BS
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00606	[Congenital disorder; Epilepsy] Ohtahara syndrome
# KEGG_Disease	H00806	[Nervous system disease] Benign familial infantile epilepsy (BFIE)
# KEGG_Pathway	ko04725	Cholinergic synapse
# MIM	121200	phenotype
# MIM	602235	gene
# MIM	613720	phenotype
# MISCELLANEOUS	KCNQ2_HUMAN	Inclusion of isoform 6 in heteromultimers results in attenuation of potassium current. Prominent expression of isoform 6 in the developing brain may alter firing repertoires of immature neurons excitability to provide cues for proliferation rather than differentiation. 
# MISCELLANEOUS	Mutagenesis experiments were carried out in Xenopus oocytes by coexpression of either KCNQ2(mut) and KCNQ3 at the ratio of 1:1, or of KCNQ2(mut), KCNQ2(wt) and KCNQ3 at the ratio of 1	1:2, to mimic the situation in a heterozygous patient with BFNC1 disease. 
# Organism	KCNQ2_HUMAN	Homo sapiens (Human)
# Orphanet	140927	Benign familial neonatal-infantile seizures
# Orphanet	1934	Early infantile epileptic encephalopathy
# Orphanet	1949	Benign familial neonatal seizures
# Orphanet	306	Benign familial infantile epilepsy
# PANTHER	PTHR11537	PTHR11537; 4
# PDB	5J03	X-ray; 2.00 A; A=530-557
# PIR	JC5275	JC5275
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01459	KCNQCHANNEL
# PRINTS	PR01461	KCNQ2CHANNEL
# PTM	KCNQ2_HUMAN	In Xenopus oocytes KCNQ2/KCNQ3 heteromeric current can be increased by intracellular cyclic AMP, an effect that depends on phosphorylation of Ser-52 in the N-terminal region. {ECO 0000269|PubMed 16319223, ECO 0000269|PubMed 9872318}. 
# Pfam	PF00520	Ion_trans
# Pfam	PF03520	KCNQ_channel
# Pfam	PF11956	KCNQC3-Ank-G_bd
# Proteomes	UP000005640	Chromosome 20
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# Reactome	R-HSA-445095	Interaction between L1 and Ankyrins
# RecName	KCNQ2_HUMAN	Potassium voltage-gated channel subfamily KQT member 2
# RefSeq	NP_004509	NM_004518.5. [O43526-3]
# RefSeq	NP_742104	NM_172106.2. [O43526-2]
# RefSeq	NP_742105	NM_172107.3. [O43526-1]
# RefSeq	NP_742106	NM_172108.4. [O43526-4]
# RefSeq	NP_742107	NM_172109.2. [O43526-6]
# SIMILARITY	Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.2/KCNQ2 sub-subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCNQ2_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	KCNQ2_HUMAN	Heteromultimer with KCNQ3. May associate with KCNE2. 
# TCDB	1.A.1.15	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	In adult and fetal brain. Highly expressed in areas containing neuronal cell bodies, low in spinal chord and corpus callosum. Isoform 2 is preferentially expressed in differentiated neurons. Isoform 6 is prominent in fetal brain, undifferentiated neuroblastoma cells and brain tumors. {ECO:0000269|PubMed	10781098}. 
# UCSC	uc002yey	human. [O43526-1]
# eggNOG	COG1226	LUCA
# eggNOG	KOG1419	Eukaryota
BLAST	swissprot:KCNQ2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNQ2_HUMAN
BioCyc	ZFISH:ENSG00000075043-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000075043-MONOMER
COXPRESdb	3785	http://coxpresdb.jp/data/gene/3785.shtml
CleanEx	HS_KCNQ2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNQ2
DOI	10.1007/s004390050941	http://dx.doi.org/10.1007/s004390050941
DOI	10.1016/S0014-5793(00)01918-9	http://dx.doi.org/10.1016/S0014-5793(00)01918-9
DOI	10.1016/S0014-5793(98)01296-4	http://dx.doi.org/10.1016/S0014-5793(98)01296-4
DOI	10.1016/S0304-3940(00)00866-1	http://dx.doi.org/10.1016/S0304-3940(00)00866-1
DOI	10.1016/S0920-1211(03)00037-8	http://dx.doi.org/10.1016/S0920-1211(03)00037-8
DOI	10.1038/25367	http://dx.doi.org/10.1038/25367
DOI	10.1038/414865a	http://dx.doi.org/10.1038/414865a
DOI	10.1038/ng0198-25	http://dx.doi.org/10.1038/ng0198-25
DOI	10.1038/sj.ejhg.5200570	http://dx.doi.org/10.1038/sj.ejhg.5200570
DOI	10.1073/pnas.0509122102	http://dx.doi.org/10.1073/pnas.0509122102
DOI	10.1073/pnas.090092797	http://dx.doi.org/10.1073/pnas.090092797
DOI	10.1073/pnas.211431298	http://dx.doi.org/10.1073/pnas.211431298
DOI	10.1074/jbc.273.31.19419	http://dx.doi.org/10.1074/jbc.273.31.19419
DOI	10.1074/jbc.275.18.13343	http://dx.doi.org/10.1074/jbc.275.18.13343
DOI	10.1093/brain/awg286	http://dx.doi.org/10.1093/brain/awg286
DOI	10.1093/dnares/3.5.311	http://dx.doi.org/10.1093/dnares/3.5.311
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1469-7793.2000.t01-2-00349.x	http://dx.doi.org/10.1111/j.1469-7793.2000.t01-2-00349.x
DOI	10.1126/science.279.5349.403	http://dx.doi.org/10.1126/science.279.5349.403
DOI	10.1126/science.282.5395.1890	http://dx.doi.org/10.1126/science.282.5395.1890
DOI	10.1186/gb-2004-5-2-r8	http://dx.doi.org/10.1186/gb-2004-5-2-r8
DOI	10.1212/01.WNL.0000132979.08394.6D	http://dx.doi.org/10.1212/01.WNL.0000132979.08394.6D
DOI	10.1212/01.wnl.0000275523.95103.36	http://dx.doi.org/10.1212/01.wnl.0000275523.95103.36
DrugBank	DB00321	http://www.drugbank.ca/drugs/DB00321
DrugBank	DB00586	http://www.drugbank.ca/drugs/DB00586
DrugBank	DB00939	http://www.drugbank.ca/drugs/DB00939
DrugBank	DB04953	http://www.drugbank.ca/drugs/DB04953
EMBL	AF033348	http://www.ebi.ac.uk/ena/data/view/AF033348
EMBL	AF074247	http://www.ebi.ac.uk/ena/data/view/AF074247
EMBL	AF110020	http://www.ebi.ac.uk/ena/data/view/AF110020
EMBL	AL121827	http://www.ebi.ac.uk/ena/data/view/AL121827
EMBL	AL121827	http://www.ebi.ac.uk/ena/data/view/AL121827
EMBL	AL121827	http://www.ebi.ac.uk/ena/data/view/AL121827
EMBL	AL121827	http://www.ebi.ac.uk/ena/data/view/AL121827
EMBL	AL121827	http://www.ebi.ac.uk/ena/data/view/AL121827
EMBL	AL121829	http://www.ebi.ac.uk/ena/data/view/AL121829
EMBL	AL121829	http://www.ebi.ac.uk/ena/data/view/AL121829
EMBL	AL121829	http://www.ebi.ac.uk/ena/data/view/AL121829
EMBL	AL121829	http://www.ebi.ac.uk/ena/data/view/AL121829
EMBL	AL121829	http://www.ebi.ac.uk/ena/data/view/AL121829
EMBL	AL353658	http://www.ebi.ac.uk/ena/data/view/AL353658
EMBL	AL353658	http://www.ebi.ac.uk/ena/data/view/AL353658
EMBL	AL353658	http://www.ebi.ac.uk/ena/data/view/AL353658
EMBL	AL353658	http://www.ebi.ac.uk/ena/data/view/AL353658
EMBL	AL353658	http://www.ebi.ac.uk/ena/data/view/AL353658
EMBL	BC000699	http://www.ebi.ac.uk/ena/data/view/BC000699
EMBL	D82346	http://www.ebi.ac.uk/ena/data/view/D82346
EMBL	Y15065	http://www.ebi.ac.uk/ena/data/view/Y15065
Ensembl	ENST00000344425	http://www.ensembl.org/id/ENST00000344425
Ensembl	ENST00000344462	http://www.ensembl.org/id/ENST00000344462
Ensembl	ENST00000359125	http://www.ensembl.org/id/ENST00000359125
Ensembl	ENST00000360480	http://www.ensembl.org/id/ENST00000360480
Ensembl	ENST00000626839	http://www.ensembl.org/id/ENST00000626839
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0033268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033268
GO_component	GO:0043194	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043194
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_function	GO:0030506	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030506
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007399	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007399
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0008092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GeneCards	KCNQ2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNQ2
GeneID	3785	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3785
GeneTree	ENSGT00550000074513	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074513
HGNC	HGNC:6296	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6296
HOVERGEN	HBG059014	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG059014&db=HOVERGEN
HPA	HPA016642	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA016642
HPA	HPA057112	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA057112
InParanoid	O43526	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O43526
IntAct	O43526	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O43526*
InterPro	IPR003937	http://www.ebi.ac.uk/interpro/entry/IPR003937
InterPro	IPR003947	http://www.ebi.ac.uk/interpro/entry/IPR003947
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR013821	http://www.ebi.ac.uk/interpro/entry/IPR013821
InterPro	IPR020969	http://www.ebi.ac.uk/interpro/entry/IPR020969
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	3785	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3785
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00606	http://www.genome.jp/dbget-bin/www_bget?H00606
KEGG_Disease	H00806	http://www.genome.jp/dbget-bin/www_bget?H00806
KEGG_Gene	hsa:3785	http://www.genome.jp/dbget-bin/www_bget?hsa:3785
KEGG_Orthology	KO:K04927	http://www.genome.jp/dbget-bin/www_bget?KO:K04927
KEGG_Pathway	ko04725	http://www.genome.jp/kegg-bin/show_pathway?ko04725
MIM	121200	http://www.ncbi.nlm.nih.gov/omim/121200
MIM	602235	http://www.ncbi.nlm.nih.gov/omim/602235
MIM	613720	http://www.ncbi.nlm.nih.gov/omim/613720
MINT	MINT-8402812	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8402812
OMA	PRQGHGT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PRQGHGT
Orphanet	140927	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=140927
Orphanet	1934	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1934
Orphanet	1949	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1949
Orphanet	306	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=306
OrthoDB	EOG091G02ZT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02ZT
PANTHER	PTHR11537	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537
PDB	5J03	http://www.ebi.ac.uk/pdbe-srv/view/entry/5J03
PDBsum	5J03	http://www.ebi.ac.uk/pdbsum/5J03
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01459	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01459
PRINTS	PR01461	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01461
PSORT	swissprot:KCNQ2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNQ2_HUMAN
PSORT-B	swissprot:KCNQ2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNQ2_HUMAN
PSORT2	swissprot:KCNQ2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNQ2_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF03520	http://pfam.xfam.org/family/PF03520
Pfam	PF11956	http://pfam.xfam.org/family/PF11956
PharmGKB	PA30074	http://www.pharmgkb.org/do/serve?objId=PA30074&objCls=Gene
Phobius	swissprot:KCNQ2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNQ2_HUMAN
PhylomeDB	O43526	http://phylomedb.org/?seqid=O43526
ProteinModelPortal	O43526	http://www.proteinmodelportal.org/query/uniprot/O43526
PubMed	10323247	http://www.ncbi.nlm.nih.gov/pubmed/10323247
PubMed	10479678	http://www.ncbi.nlm.nih.gov/pubmed/10479678
PubMed	10684873	http://www.ncbi.nlm.nih.gov/pubmed/10684873
PubMed	10713399	http://www.ncbi.nlm.nih.gov/pubmed/10713399
PubMed	10713961	http://www.ncbi.nlm.nih.gov/pubmed/10713961
PubMed	10781098	http://www.ncbi.nlm.nih.gov/pubmed/10781098
PubMed	10788442	http://www.ncbi.nlm.nih.gov/pubmed/10788442
PubMed	10908292	http://www.ncbi.nlm.nih.gov/pubmed/10908292
PubMed	10953053	http://www.ncbi.nlm.nih.gov/pubmed/10953053
PubMed	11034315	http://www.ncbi.nlm.nih.gov/pubmed/11034315
PubMed	11160379	http://www.ncbi.nlm.nih.gov/pubmed/11160379
PubMed	11175290	http://www.ncbi.nlm.nih.gov/pubmed/11175290
PubMed	11572947	http://www.ncbi.nlm.nih.gov/pubmed/11572947
PubMed	11780052	http://www.ncbi.nlm.nih.gov/pubmed/11780052
PubMed	12742592	http://www.ncbi.nlm.nih.gov/pubmed/12742592
PubMed	14534157	http://www.ncbi.nlm.nih.gov/pubmed/14534157
PubMed	14759258	http://www.ncbi.nlm.nih.gov/pubmed/14759258
PubMed	15249611	http://www.ncbi.nlm.nih.gov/pubmed/15249611
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16319223	http://www.ncbi.nlm.nih.gov/pubmed/16319223
PubMed	17872363	http://www.ncbi.nlm.nih.gov/pubmed/17872363
PubMed	9039501	http://www.ncbi.nlm.nih.gov/pubmed/9039501
PubMed	9425895	http://www.ncbi.nlm.nih.gov/pubmed/9425895
PubMed	9430594	http://www.ncbi.nlm.nih.gov/pubmed/9430594
PubMed	9677360	http://www.ncbi.nlm.nih.gov/pubmed/9677360
PubMed	9827540	http://www.ncbi.nlm.nih.gov/pubmed/9827540
PubMed	9836639	http://www.ncbi.nlm.nih.gov/pubmed/9836639
PubMed	9872318	http://www.ncbi.nlm.nih.gov/pubmed/9872318
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
Reactome	R-HSA-445095	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-445095
RefSeq	NP_004509	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004509
RefSeq	NP_742104	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_742104
RefSeq	NP_742105	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_742105
RefSeq	NP_742106	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_742106
RefSeq	NP_742107	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_742107
STRING	9606.ENSP00000352035	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000352035&targetmode=cogs
TCDB	1.A.1.15	http://www.tcdb.org/search/result.php?tc=1.A.1.15
UCSC	uc002yey	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002yey&org=rat
UniGene	Hs.161851	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.161851
UniGene	Hs.652468	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.652468
UniProtKB	KCNQ2_HUMAN	http://www.uniprot.org/uniprot/KCNQ2_HUMAN
UniProtKB-AC	O43526	http://www.uniprot.org/uniprot/O43526
charge	swissprot:KCNQ2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNQ2_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG1419	http://eggnogapi.embl.de/nog_data/html/tree/KOG1419
epestfind	swissprot:KCNQ2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNQ2_HUMAN
garnier	swissprot:KCNQ2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNQ2_HUMAN
helixturnhelix	swissprot:KCNQ2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNQ2_HUMAN
hmoment	swissprot:KCNQ2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNQ2_HUMAN
iep	swissprot:KCNQ2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNQ2_HUMAN
inforesidue	swissprot:KCNQ2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNQ2_HUMAN
neXtProt	NX_O43526	http://www.nextprot.org/db/entry/NX_O43526
octanol	swissprot:KCNQ2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNQ2_HUMAN
pepcoil	swissprot:KCNQ2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNQ2_HUMAN
pepdigest	swissprot:KCNQ2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNQ2_HUMAN
pepinfo	swissprot:KCNQ2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNQ2_HUMAN
pepnet	swissprot:KCNQ2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNQ2_HUMAN
pepstats	swissprot:KCNQ2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNQ2_HUMAN
pepwheel	swissprot:KCNQ2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNQ2_HUMAN
pepwindow	swissprot:KCNQ2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNQ2_HUMAN
sigcleave	swissprot:KCNQ2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNQ2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SC6A9_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=GlyT-1C; IsoId=P48067-1; Sequence=Displayed; Name=GlyT-1A; IsoId=P48067-2; Sequence=VSP_006270; Name=GlyT-1B; IsoId=P48067-3; Sequence=VSP_006271; 
# AltName	SC6A9_HUMAN	Solute carrier family 6 member 9
# BioGrid	112427	5
# CCDS	CCDS30695	-. [P48067-2]
# CCDS	CCDS41316	-. [P48067-3]
# CCDS	CCDS41317	-. [P48067-1]
# ChiTaRS	SLC6A9	human
# DrugBank	DB00145	Glycine
# Ensembl	ENST00000357730	ENSP00000350362; ENSG00000196517. [P48067-3]
# Ensembl	ENST00000360584	ENSP00000353791; ENSG00000196517. [P48067-1]
# Ensembl	ENST00000372310	ENSP00000361384; ENSG00000196517. [P48067-2]
# ExpressionAtlas	P48067	baseline and differential
# FUNCTION	SC6A9_HUMAN	Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0098793	presynapse; IEA:GOC.
# GO_function	SC6A9_HUMAN	GO 0005328 neurotransmitter sodium symporter activity; IEA InterPro.
# GO_function	SC6A9_HUMAN	GO 0015375 glycine sodium symporter activity; TAS Reactome.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0036233	glycine import; IBA:GO_Central.
# GO_process	GO:0060012	synaptic transmission, glycinergic; IBA:GO_Central.
# GO_process	GO:0061537	glycine secretion, neurotransmission; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# Genevisible	P48067	HS
# HGNC	HGNC:11056	SLC6A9
# IntAct	P48067	4
# InterPro	IPR000175	Na/ntran_symport
# InterPro	IPR003028	Na/ntran_symport_glycine_GLY1
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Brite	ko04040	 Ion channels
# MIM	601019	gene
# Organism	SC6A9_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11616	PTHR11616; 2
# PIR	I57956	I57956
# PIR	I77912	I77912
# PRINTS	PR00176	NANEUSMPORT
# PRINTS	PR01204	GLY1TRNSPORT
# PROSITE	PS00610	NA_NEUROTRAN_SYMP_1
# PROSITE	PS00754	NA_NEUROTRAN_SYMP_2
# PROSITE	PS50267	NA_NEUROTRAN_SYMP_3
# Pfam	PF00209	SNF
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-442660	Na+/Cl- dependent neurotransmitter transporters
# RecName	SC6A9_HUMAN	Sodium- and chloride-dependent glycine transporter 1
# RefSeq	NP_001020016	NM_001024845.2. [P48067-2]
# RefSeq	NP_001315558	NM_001328629.1. [P48067-2]
# RefSeq	NP_008865	NM_006934.3. [P48067-3]
# RefSeq	NP_964012	NM_201649.3. [P48067-1]
# SEQUENCE CAUTION	SC6A9_HUMAN	Sequence=AAB30784.1; Type=Frameshift; Positions=8; Evidence={ECO 0000305}; Sequence=AAB30785.1; Type=Frameshift; Positions=8; Evidence={ECO 0000305}; Sequence=CAI19428.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=CAI19429.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305};
# SIMILARITY	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	SC6A9_HUMAN	Membrane; Multi-pass membrane protein. 
# TCDB	2.A.22.2.12:the neurotransmitter	sodium symporter (nss) family
# TISSUE SPECIFICITY	SC6A9_HUMAN	Isoform GlyT-1A and isoform GlyT-1B can be found in brain, kidney, pancreas, lung, placenta and liver but isoform GlyT-1C is only found in brain. 
# UCSC	uc001cll	human. [P48067-1]
# eggNOG	COG0733	LUCA
# eggNOG	KOG3659	Eukaryota
BLAST	swissprot:SC6A9_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SC6A9_HUMAN
BioCyc	ZFISH:G66-31595-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31595-MONOMER
COXPRESdb	6536	http://coxpresdb.jp/data/gene/6536.shtml
CleanEx	HS_SLC6A9	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC6A9
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DrugBank	DB00145	http://www.drugbank.ca/drugs/DB00145
EMBL	AL139220	http://www.ebi.ac.uk/ena/data/view/AL139220
EMBL	AL139220	http://www.ebi.ac.uk/ena/data/view/AL139220
EMBL	AL139220	http://www.ebi.ac.uk/ena/data/view/AL139220
EMBL	CH471059	http://www.ebi.ac.uk/ena/data/view/CH471059
EMBL	CH471059	http://www.ebi.ac.uk/ena/data/view/CH471059
EMBL	S70609	http://www.ebi.ac.uk/ena/data/view/S70609
EMBL	S70612	http://www.ebi.ac.uk/ena/data/view/S70612
Ensembl	ENST00000357730	http://www.ensembl.org/id/ENST00000357730
Ensembl	ENST00000360584	http://www.ensembl.org/id/ENST00000360584
Ensembl	ENST00000372310	http://www.ensembl.org/id/ENST00000372310
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0098793	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098793
GO_function	GO:0005328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005328
GO_function	GO:0015375	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015375
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0036233	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036233
GO_process	GO:0060012	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060012
GO_process	GO:0061537	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061537
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GeneCards	SLC6A9	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC6A9
GeneID	6536	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6536
GeneTree	ENSGT00760000118857	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118857
HGNC	HGNC:11056	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11056
HOVERGEN	HBG071421	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG071421&db=HOVERGEN
HPA	HPA013977	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA013977
InParanoid	P48067	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P48067
IntAct	P48067	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P48067*
InterPro	IPR000175	http://www.ebi.ac.uk/interpro/entry/IPR000175
InterPro	IPR003028	http://www.ebi.ac.uk/interpro/entry/IPR003028
Jabion	6536	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6536
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:6536	http://www.genome.jp/dbget-bin/www_bget?hsa:6536
KEGG_Orthology	KO:K05038	http://www.genome.jp/dbget-bin/www_bget?KO:K05038
MIM	601019	http://www.ncbi.nlm.nih.gov/omim/601019
OrthoDB	EOG091G08PX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08PX
PANTHER	PTHR11616	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11616
PRINTS	PR00176	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00176
PRINTS	PR01204	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01204
PROSITE	PS00610	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00610
PROSITE	PS00754	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00754
PROSITE	PS50267	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50267
PSORT	swissprot:SC6A9_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SC6A9_HUMAN
PSORT-B	swissprot:SC6A9_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SC6A9_HUMAN
PSORT2	swissprot:SC6A9_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SC6A9_HUMAN
Pfam	PF00209	http://pfam.xfam.org/family/PF00209
PharmGKB	PA35916	http://www.pharmgkb.org/do/serve?objId=PA35916&objCls=Gene
Phobius	swissprot:SC6A9_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SC6A9_HUMAN
PhylomeDB	P48067	http://phylomedb.org/?seqid=P48067
ProteinModelPortal	P48067	http://www.proteinmodelportal.org/query/uniprot/P48067
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	8183239	http://www.ncbi.nlm.nih.gov/pubmed/8183239
Reactome	R-HSA-442660	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442660
RefSeq	NP_001020016	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001020016
RefSeq	NP_001315558	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001315558
RefSeq	NP_008865	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_008865
RefSeq	NP_964012	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_964012
STRING	9606.ENSP00000353791	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000353791&targetmode=cogs
TCDB	2.A.22.2.12	http://www.tcdb.org/search/result.php?tc=2.A.22.2.12
UCSC	uc001cll	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001cll&org=rat
UniGene	Hs.442590	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.442590
UniProtKB	SC6A9_HUMAN	http://www.uniprot.org/uniprot/SC6A9_HUMAN
UniProtKB-AC	P48067	http://www.uniprot.org/uniprot/P48067
charge	swissprot:SC6A9_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SC6A9_HUMAN
eggNOG	COG0733	http://eggnogapi.embl.de/nog_data/html/tree/COG0733
eggNOG	KOG3659	http://eggnogapi.embl.de/nog_data/html/tree/KOG3659
epestfind	swissprot:SC6A9_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SC6A9_HUMAN
garnier	swissprot:SC6A9_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SC6A9_HUMAN
helixturnhelix	swissprot:SC6A9_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SC6A9_HUMAN
hmoment	swissprot:SC6A9_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SC6A9_HUMAN
iep	swissprot:SC6A9_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SC6A9_HUMAN
inforesidue	swissprot:SC6A9_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SC6A9_HUMAN
neXtProt	NX_P48067	http://www.nextprot.org/db/entry/NX_P48067
octanol	swissprot:SC6A9_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SC6A9_HUMAN
pepcoil	swissprot:SC6A9_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SC6A9_HUMAN
pepdigest	swissprot:SC6A9_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SC6A9_HUMAN
pepinfo	swissprot:SC6A9_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SC6A9_HUMAN
pepnet	swissprot:SC6A9_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SC6A9_HUMAN
pepstats	swissprot:SC6A9_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SC6A9_HUMAN
pepwheel	swissprot:SC6A9_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SC6A9_HUMAN
pepwindow	swissprot:SC6A9_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SC6A9_HUMAN
sigcleave	swissprot:SC6A9_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SC6A9_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	P2RX7_HUMAN	Event=Alternative splicing; Named isoforms=8; Name=A; IsoId=Q99572-1; Sequence=Displayed; Name=B; Synonyms=Delta-C, cytoplasmic tail deleted; IsoId=Q99572-2; Sequence=VSP_047784, VSP_047785; Note=Predominant form in many tissues.; Name=C; IsoId=Q99572-3; Sequence=VSP_047781, VSP_047782; Name=D; IsoId=Q99572-4; Sequence=VSP_047777, VSP_047780; Name=E; IsoId=Q99572-5; Sequence=VSP_047783, VSP_047784, VSP_047785; Name=F; IsoId=Q99572-6; Sequence=VSP_047778, VSP_047779; Name=G; IsoId=Q99572-7; Sequence=VSP_047776, VSP_047784, VSP_047785; Name=H; Synonyms=Delta-TM1; IsoId=Q99572-8; Sequence=VSP_047776; Note=Non-functional channel.; 
# AltName	P2RX7_HUMAN	ATP receptor
# AltName	P2RX7_HUMAN	P2Z receptor
# AltName	P2RX7_HUMAN	Purinergic receptor
# BioGrid	111066	5
# CCDS	CCDS9213	-. [Q99572-1]
# ChiTaRS	P2RX7	human
# Ensembl	ENST00000328963	ENSP00000330696; ENSG00000089041. [Q99572-1]
# Ensembl	ENST00000535250	ENSP00000442572; ENSG00000089041. [Q99572-2]
# Ensembl	ENST00000535600	ENSP00000442470; ENSG00000089041. [Q99572-5]
# Ensembl	ENST00000541022	ENSP00000441230; ENSG00000089041. [Q99572-3]
# Ensembl	ENST00000541716	ENSP00000437729; ENSG00000089041. [Q99572-3]
# ExpressionAtlas	Q99572	baseline and differential
# FUNCTION	P2RX7_HUMAN	Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. 
# GO_component	GO:0005639	integral component of nuclear inner membrane; IBA:GO_Central.
# GO_component	GO:0005737	cytoplasm; ISS:BHF-UCL.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IC:BHF-UCL.
# GO_component	GO:0005911	cell-cell junction; IEA:Ensembl.
# GO_component	GO:0009897	external side of plasma membrane; IEA:Ensembl.
# GO_component	GO:0016020	membrane; IDA:BHF-UCL.
# GO_component	GO:0031594	neuromuscular junction; IEA:Ensembl.
# GO_component	GO:0032059	bleb; ISS:BHF-UCL.
# GO_component	GO:0043025	neuronal cell body; IEA:Ensembl.
# GO_component	GO:0098793	presynapse; IEA:GOC.
# GO_function	GO:0001530	lipopolysaccharide binding; ISS:BHF-UCL.
# GO_function	GO:0001614	purinergic nucleotide receptor activity; IDA:BHF-UCL.
# GO_function	GO:0004931	extracellular ATP-gated cation channel activity; IDA:BHF-UCL.
# GO_function	GO:0005102	receptor binding; ISS:BHF-UCL.
# GO_function	GO:0005524	ATP binding; IC:BHF-UCL.
# GO_function	GO:0042803	protein homodimerization activity; NAS:BHF-UCL.
# GO_process	GO:0000187	activation of MAPK activity; IEA:Ensembl.
# GO_process	GO:0000902	cell morphogenesis; IEA:Ensembl.
# GO_process	GO:0001845	phagolysosome assembly; IEA:Ensembl.
# GO_process	GO:0001916	positive regulation of T cell mediated cytotoxicity; IEA:Ensembl.
# GO_process	GO:0002028	regulation of sodium ion transport; ISS:BHF-UCL.
# GO_process	GO:0006468	protein phosphorylation; IEA:Ensembl.
# GO_process	GO:0006509	membrane protein ectodomain proteolysis; IEA:Ensembl.
# GO_process	GO:0006649	phospholipid transfer to membrane; IEA:Ensembl.
# GO_process	GO:0006900	membrane budding; IEA:Ensembl.
# GO_process	GO:0006954	inflammatory response; IEA:Ensembl.
# GO_process	GO:0007005	mitochondrion organization; IEA:Ensembl.
# GO_process	GO:0007166	cell surface receptor signaling pathway; ISS:BHF-UCL.
# GO_process	GO:0007596	blood coagulation; TAS:Reactome.
# GO_process	GO:0009612	response to mechanical stimulus; IEA:Ensembl.
# GO_process	GO:0010043	response to zinc ion; IEA:Ensembl.
# GO_process	GO:0010524	positive regulation of calcium ion transport into cytosol; IDA:BHF-UCL.
# GO_process	GO:0010628	positive regulation of gene expression; IMP:CACAO.
# GO_process	GO:0014049	positive regulation of glutamate secretion; IEA:Ensembl.
# GO_process	GO:0014054	positive regulation of gamma-aminobutyric acid secretion; IEA:Ensembl.
# GO_process	GO:0016079	synaptic vesicle exocytosis; IEA:Ensembl.
# GO_process	GO:0016485	protein processing; IEA:Ensembl.
# GO_process	GO:0017121	phospholipid scrambling; IDA:UniProtKB.
# GO_process	GO:0019233	sensory perception of pain; ISS:BHF-UCL.
# GO_process	GO:0019835	cytolysis; IEA:Ensembl.
# GO_process	GO:0030501	positive regulation of bone mineralization; ISS:BHF-UCL.
# GO_process	GO:0031668	cellular response to extracellular stimulus; IEA:Ensembl.
# GO_process	GO:0032060	bleb assembly; IDA:UniProtKB.
# GO_process	GO:0032308	positive regulation of prostaglandin secretion; IEA:Ensembl.
# GO_process	GO:0032496	response to lipopolysaccharide; IEA:Ensembl.
# GO_process	GO:0032755	positive regulation of interleukin-6 production; IEA:Ensembl.
# GO_process	GO:0032963	collagen metabolic process; IEA:Ensembl.
# GO_process	GO:0033198	response to ATP; IDA:BHF-UCL.
# GO_process	GO:0034405	response to fluid shear stress; IEA:Ensembl.
# GO_process	GO:0034767	positive regulation of ion transmembrane transport; IMP:UniProtKB.
# GO_process	GO:0035590	purinergic nucleotide receptor signaling pathway; IMP:UniProtKB.
# GO_process	GO:0042098	T cell proliferation; IEA:Ensembl.
# GO_process	GO:0042493	response to drug; IEA:Ensembl.
# GO_process	GO:0043029	T cell homeostasis; IEA:Ensembl.
# GO_process	GO:0043132	NAD transport; IEA:Ensembl.
# GO_process	GO:0043409	negative regulation of MAPK cascade; ISS:BHF-UCL.
# GO_process	GO:0044254	multicellular organismal protein catabolic process; IEA:Ensembl.
# GO_process	GO:0045332	phospholipid translocation; IEA:Ensembl.
# GO_process	GO:0045779	negative regulation of bone resorption; ISS:BHF-UCL.
# GO_process	GO:0045794	negative regulation of cell volume; IMP:UniProtKB.
# GO_process	GO:0045821	positive regulation of glycolytic process; IMP:CACAO.
# GO_process	GO:0045919	positive regulation of cytolysis; ISS:BHF-UCL.
# GO_process	GO:0046513	ceramide biosynthetic process; IEA:Ensembl.
# GO_process	GO:0046931	pore complex assembly; IMP:UniProtKB.
# GO_process	GO:0048705	skeletal system morphogenesis; IEA:Ensembl.
# GO_process	GO:0048873	homeostasis of number of cells within a tissue; IEA:Ensembl.
# GO_process	GO:0050717	positive regulation of interleukin-1 alpha secretion; IEA:Ensembl.
# GO_process	GO:0050718	positive regulation of interleukin-1 beta secretion; IDA:BHF-UCL.
# GO_process	GO:0050830	defense response to Gram-positive bacterium; IEA:Ensembl.
# GO_process	GO:0051209	release of sequestered calcium ion into cytosol; IEA:Ensembl.
# GO_process	GO:0051259	protein oligomerization; IEA:Ensembl.
# GO_process	GO:0051495	positive regulation of cytoskeleton organization; ISS:BHF-UCL.
# GO_process	GO:0051592	response to calcium ion; IEA:Ensembl.
# GO_process	GO:0051602	response to electrical stimulus; IEA:Ensembl.
# GO_process	GO:0051709	regulation of killing of cells of other organism; NAS:BHF-UCL.
# GO_process	GO:0051899	membrane depolarization; IDA:BHF-UCL.
# GO_process	GO:0051901	positive regulation of mitochondrial depolarization; IEA:Ensembl.
# GO_process	GO:0070230	positive regulation of lymphocyte apoptotic process; IEA:Ensembl.
# GO_process	GO:0071359	cellular response to dsRNA; IEA:Ensembl.
# GO_process	GO:0072593	reactive oxygen species metabolic process; IEA:Ensembl.
# GO_process	GO:0097190	apoptotic signaling pathway; ISS:BHF-UCL.
# GO_process	GO:0097191	extrinsic apoptotic signaling pathway; IEA:Ensembl.
# GO_process	GO:1904172	positive regulation of bleb assembly; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0008289	lipid binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0000902	cell morphogenesis
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007005	mitochondrion organization
# GOslim_process	GO:0007009	plasma membrane organization
# GOslim_process	GO:0007155	cell adhesion
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0008283	cell proliferation
# GOslim_process	GO:0009056	catabolic process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0022607	cellular component assembly
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0051604	protein maturation
# GOslim_process	GO:0055085	transmembrane transport
# GOslim_process	GO:0061024	membrane organization
# Gene3D	2.60.490.10	-; 1.
# Genevisible	Q99572	HS
# HGNC	HGNC:8537	P2RX7
# IntAct	Q99572	12
# InterPro	IPR001429	P2X_purnocptor
# InterPro	IPR003050	P2X7_purnocptor
# InterPro	IPR027309	P2X_extracellular_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# MIM	602566	gene
# Organism	P2RX7_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10125	PTHR10125; 3
# PANTHER	PTHR10125:SF13	PTHR10125:SF13; 3
# PRINTS	PR01307	P2XRECEPTOR
# PRINTS	PR01314	P2X7RECEPTOR
# PROSITE	PS01212	P2X_RECEPTOR
# PTM	P2RX7_HUMAN	ADP-ribosylation at Arg-125 is necessary and sufficient to activate P2RX7 and gate the channel. {ECO 0000250}. 
# PTM	P2RX7_HUMAN	Palmitoylation of several cysteines in the C-terminal cytoplasmic tail is required for efficient localization to cell surface. {ECO 0000269|PubMed 18971257}. 
# PTM	P2RX7_HUMAN	Phosphorylation results in its inactivation. {ECO 0000269|PubMed 11707406}. 
# Pfam	PF00864	P2X_receptor
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-139853	Elevation of cytosolic Ca2+ levels
# Reactome	R-HSA-418346	Platelet homeostasis
# Reactome	R-HSA-844456	The NLRP3 inflammasome
# RecName	P2RX7_HUMAN	P2X purinoceptor 7
# RefSeq	NP_002553	NM_002562.5. [Q99572-1]
# RefSeq	XP_011536722	XM_011538420.2. [Q99572-6]
# SIMILARITY	Belongs to the P2X receptor family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	P2RX7_HUMAN	Cell membrane {ECO 0000269|PubMed 12107182}; Multi-pass membrane protein. 
# SUBUNIT	P2RX7_HUMAN	Functional P2XRs are organized as homomeric and heteromeric trimers. Interacts with LAMA3, ITGB2, ACTB, ACTN4, SVIL, MPP3, HSPA1, HSPCB, HSPA8, PIK230 and PTPRB. Interacts (via C-terminus) with EMP2 (PubMed 12107182). {ECO 0000269|PubMed 11707406, ECO 0000269|PubMed 12107182}. 
# TCDB	1.A.7.1	the atp-gated p2x receptor cation channel (p2x receptor) family
# TIGRFAMs	TIGR00863	P2X
# TISSUE SPECIFICITY	Widely expressed with highest levels in brain and immune tissues. {ECO:0000269|PubMed	15896293}. 
# UCSC	uc001tzm	human. [Q99572-1]
# WEB RESOURCE	P2RX7_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/P2RX7ID41623ch12q24.html"; 
# WEB RESOURCE	P2RX7_HUMAN	Name=Wikipedia; Note=P2RX7 entry; URL="http //en.wikipedia.org/wiki/P2RX7";
# WEB RESOURCE	P2RX7_HUMAN	Name=Wikipedia; Note=P2X receptor entry; URL="https //en.wikipedia.org/wiki/P2X_receptor"; 
# eggNOG	ENOG410IK4U	Eukaryota
# eggNOG	ENOG4110DDY	LUCA
BLAST	swissprot:P2RX7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:P2RX7_HUMAN
BioCyc	ZFISH:ENSG00000089041-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000089041-MONOMER
COXPRESdb	5027	http://coxpresdb.jp/data/gene/5027.shtml
CleanEx	HS_P2RX7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_P2RX7
DOI	10.1016/j.bbrc.2005.04.087	http://dx.doi.org/10.1016/j.bbrc.2005.04.087
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/bi902083n	http://dx.doi.org/10.1021/bi902083n
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.272.9.5482	http://dx.doi.org/10.1074/jbc.272.9.5482
DOI	10.1074/jbc.M010353200	http://dx.doi.org/10.1074/jbc.M010353200
DOI	10.1074/jbc.M205120200	http://dx.doi.org/10.1074/jbc.M205120200
DOI	10.1074/jbc.M212759200	http://dx.doi.org/10.1074/jbc.M212759200
DOI	10.1074/jbc.M313902200	http://dx.doi.org/10.1074/jbc.M313902200
DOI	10.1093/emboj/20.22.6347	http://dx.doi.org/10.1093/emboj/20.22.6347
DOI	10.1096/fj.08-114637	http://dx.doi.org/10.1096/fj.08-114637
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
EMBL	AC069209	http://www.ebi.ac.uk/ena/data/view/AC069209
EMBL	AC079602	http://www.ebi.ac.uk/ena/data/view/AC079602
EMBL	AK290405	http://www.ebi.ac.uk/ena/data/view/AK290405
EMBL	AK294126	http://www.ebi.ac.uk/ena/data/view/AK294126
EMBL	AY847298	http://www.ebi.ac.uk/ena/data/view/AY847298
EMBL	AY847299	http://www.ebi.ac.uk/ena/data/view/AY847299
EMBL	AY847300	http://www.ebi.ac.uk/ena/data/view/AY847300
EMBL	AY847301	http://www.ebi.ac.uk/ena/data/view/AY847301
EMBL	AY847302	http://www.ebi.ac.uk/ena/data/view/AY847302
EMBL	AY847303	http://www.ebi.ac.uk/ena/data/view/AY847303
EMBL	AY847304	http://www.ebi.ac.uk/ena/data/view/AY847304
EMBL	BC007679	http://www.ebi.ac.uk/ena/data/view/BC007679
EMBL	BC011913	http://www.ebi.ac.uk/ena/data/view/BC011913
EMBL	Y09561	http://www.ebi.ac.uk/ena/data/view/Y09561
EMBL	Y12851	http://www.ebi.ac.uk/ena/data/view/Y12851
EMBL	Y12852	http://www.ebi.ac.uk/ena/data/view/Y12852
EMBL	Y12853	http://www.ebi.ac.uk/ena/data/view/Y12853
EMBL	Y12854	http://www.ebi.ac.uk/ena/data/view/Y12854
EMBL	Y12855	http://www.ebi.ac.uk/ena/data/view/Y12855
EMBL	Z98941	http://www.ebi.ac.uk/ena/data/view/Z98941
Ensembl	ENST00000328963	http://www.ensembl.org/id/ENST00000328963
Ensembl	ENST00000535250	http://www.ensembl.org/id/ENST00000535250
Ensembl	ENST00000535600	http://www.ensembl.org/id/ENST00000535600
Ensembl	ENST00000541022	http://www.ensembl.org/id/ENST00000541022
Ensembl	ENST00000541716	http://www.ensembl.org/id/ENST00000541716
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005639	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005639
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005911	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005911
GO_component	GO:0009897	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009897
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0031594	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031594
GO_component	GO:0032059	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032059
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0098793	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098793
GO_function	GO:0001530	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001530
GO_function	GO:0001614	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001614
GO_function	GO:0004931	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004931
GO_function	GO:0005102	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005102
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_process	GO:0000187	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000187
GO_process	GO:0000902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000902
GO_process	GO:0001845	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001845
GO_process	GO:0001916	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001916
GO_process	GO:0002028	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002028
GO_process	GO:0006468	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006468
GO_process	GO:0006509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006509
GO_process	GO:0006649	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006649
GO_process	GO:0006900	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006900
GO_process	GO:0006954	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006954
GO_process	GO:0007005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007005
GO_process	GO:0007166	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007166
GO_process	GO:0007596	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007596
GO_process	GO:0009612	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009612
GO_process	GO:0010043	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010043
GO_process	GO:0010524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010524
GO_process	GO:0010628	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010628
GO_process	GO:0014049	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014049
GO_process	GO:0014054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014054
GO_process	GO:0016079	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016079
GO_process	GO:0016485	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016485
GO_process	GO:0017121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017121
GO_process	GO:0019233	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019233
GO_process	GO:0019835	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019835
GO_process	GO:0030501	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030501
GO_process	GO:0031668	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031668
GO_process	GO:0032060	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032060
GO_process	GO:0032308	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032308
GO_process	GO:0032496	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032496
GO_process	GO:0032755	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032755
GO_process	GO:0032963	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032963
GO_process	GO:0033198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033198
GO_process	GO:0034405	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034405
GO_process	GO:0034767	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034767
GO_process	GO:0035590	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035590
GO_process	GO:0042098	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042098
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0043029	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043029
GO_process	GO:0043132	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043132
GO_process	GO:0043409	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043409
GO_process	GO:0044254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044254
GO_process	GO:0045332	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045332
GO_process	GO:0045779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045779
GO_process	GO:0045794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045794
GO_process	GO:0045821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045821
GO_process	GO:0045919	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045919
GO_process	GO:0046513	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046513
GO_process	GO:0046931	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046931
GO_process	GO:0048705	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048705
GO_process	GO:0048873	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048873
GO_process	GO:0050717	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050717
GO_process	GO:0050718	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050718
GO_process	GO:0050830	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050830
GO_process	GO:0051209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051209
GO_process	GO:0051259	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051259
GO_process	GO:0051495	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051495
GO_process	GO:0051592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051592
GO_process	GO:0051602	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051602
GO_process	GO:0051709	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051709
GO_process	GO:0051899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051899
GO_process	GO:0051901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051901
GO_process	GO:0070230	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070230
GO_process	GO:0071359	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071359
GO_process	GO:0072593	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072593
GO_process	GO:0097190	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097190
GO_process	GO:0097191	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097191
GO_process	GO:1904172	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1904172
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0000902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000902
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007005
GOslim_process	GO:0007009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007009
GOslim_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0008283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008283
GOslim_process	GO:0009056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0022607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0051604	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
Gene3D	2.60.490.10	http://www.cathdb.info/version/latest/superfamily/2.60.490.10
GeneCards	P2RX7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=P2RX7
GeneID	5027	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5027
GeneTree	ENSGT00390000016028	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000016028
HGNC	HGNC:8537	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:8537
HOGENOM	HOG000232042	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000232042&db=HOGENOM6
HOVERGEN	HBG053086	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053086&db=HOVERGEN
HPA	HPA034968	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA034968
HPA	HPA042013	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042013
HPA	HPA044141	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA044141
InParanoid	Q99572	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q99572
IntAct	Q99572	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q99572*
InterPro	IPR001429	http://www.ebi.ac.uk/interpro/entry/IPR001429
InterPro	IPR003050	http://www.ebi.ac.uk/interpro/entry/IPR003050
InterPro	IPR027309	http://www.ebi.ac.uk/interpro/entry/IPR027309
Jabion	5027	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=5027
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:5027	http://www.genome.jp/dbget-bin/www_bget?hsa:5027
KEGG_Orthology	KO:K05220	http://www.genome.jp/dbget-bin/www_bget?KO:K05220
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
MIM	602566	http://www.ncbi.nlm.nih.gov/omim/602566
MINT	MINT-3972963	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3972963
OMA	LCPEYPT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LCPEYPT
OrthoDB	EOG091G0A2U	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0A2U
PANTHER	PTHR10125	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10125
PANTHER	PTHR10125:SF13	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10125:SF13
PRINTS	PR01307	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01307
PRINTS	PR01314	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01314
PROSITE	PS01212	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01212
PSORT	swissprot:P2RX7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:P2RX7_HUMAN
PSORT-B	swissprot:P2RX7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:P2RX7_HUMAN
PSORT2	swissprot:P2RX7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:P2RX7_HUMAN
Pfam	PF00864	http://pfam.xfam.org/family/PF00864
PharmGKB	PA32866	http://www.pharmgkb.org/do/serve?objId=PA32866&objCls=Gene
Phobius	swissprot:P2RX7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:P2RX7_HUMAN
ProteinModelPortal	Q99572	http://www.proteinmodelportal.org/query/uniprot/Q99572
PubMed	11150303	http://www.ncbi.nlm.nih.gov/pubmed/11150303
PubMed	11707406	http://www.ncbi.nlm.nih.gov/pubmed/11707406
PubMed	12107182	http://www.ncbi.nlm.nih.gov/pubmed/12107182
PubMed	12586825	http://www.ncbi.nlm.nih.gov/pubmed/12586825
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15123679	http://www.ncbi.nlm.nih.gov/pubmed/15123679
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15896293	http://www.ncbi.nlm.nih.gov/pubmed/15896293
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	18971257	http://www.ncbi.nlm.nih.gov/pubmed/18971257
PubMed	20450227	http://www.ncbi.nlm.nih.gov/pubmed/20450227
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	9038151	http://www.ncbi.nlm.nih.gov/pubmed/9038151
PubMed	9826911	http://www.ncbi.nlm.nih.gov/pubmed/9826911
Reactome	R-HSA-139853	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-139853
Reactome	R-HSA-418346	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418346
Reactome	R-HSA-844456	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-844456
RefSeq	NP_002553	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002553
RefSeq	XP_011536722	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011536722
SMR	Q99572	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q99572
STRING	9606.ENSP00000442349	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000442349&targetmode=cogs
TCDB	1.A.7.1	http://www.tcdb.org/search/result.php?tc=1.A.7.1
TIGRFAMs	TIGR00863	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00863
UCSC	uc001tzm	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001tzm&org=rat
UniGene	Hs.729169	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.729169
UniProtKB	P2RX7_HUMAN	http://www.uniprot.org/uniprot/P2RX7_HUMAN
UniProtKB-AC	Q99572	http://www.uniprot.org/uniprot/Q99572
charge	swissprot:P2RX7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:P2RX7_HUMAN
eggNOG	ENOG410IK4U	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IK4U
eggNOG	ENOG4110DDY	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110DDY
epestfind	swissprot:P2RX7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:P2RX7_HUMAN
garnier	swissprot:P2RX7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:P2RX7_HUMAN
helixturnhelix	swissprot:P2RX7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:P2RX7_HUMAN
hmoment	swissprot:P2RX7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:P2RX7_HUMAN
iep	swissprot:P2RX7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:P2RX7_HUMAN
inforesidue	swissprot:P2RX7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:P2RX7_HUMAN
neXtProt	NX_Q99572	http://www.nextprot.org/db/entry/NX_Q99572
octanol	swissprot:P2RX7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:P2RX7_HUMAN
pepcoil	swissprot:P2RX7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:P2RX7_HUMAN
pepdigest	swissprot:P2RX7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:P2RX7_HUMAN
pepinfo	swissprot:P2RX7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:P2RX7_HUMAN
pepnet	swissprot:P2RX7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:P2RX7_HUMAN
pepstats	swissprot:P2RX7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:P2RX7_HUMAN
pepwheel	swissprot:P2RX7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:P2RX7_HUMAN
pepwindow	swissprot:P2RX7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:P2RX7_HUMAN
sigcleave	swissprot:P2RX7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:P2RX7_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNK9_HUMAN	Acid-sensitive potassium channel protein TASK-3
# AltName	KCNK9_HUMAN	TWIK-related acid-sensitive K(+) channel 3
# AltName	KCNK9_HUMAN	Two pore potassium channel KT3.2
# BioGrid	119456	2
# ChiTaRS	KCNK9	human
# DISEASE	KCNK9_HUMAN	Birk-Barel mental retardation dysmorphism syndrome (BIBAS) [MIM 612292]  A syndrome characterized by mental retardation, hypotonia, hyperactivity, and facial dysmorphism. {ECO 0000269|PubMed 18678320}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00561	Doxapram
# DrugBank	DB01159	Halothane
# Ensembl	ENST00000303015	ENSP00000302166; ENSG00000169427
# Ensembl	ENST00000520439	ENSP00000430676; ENSG00000169427
# Ensembl	ENST00000522317	ENSP00000429847; ENSG00000169427
# ExpressionAtlas	Q9NPC2	baseline and differential
# FUNCTION	KCNK9_HUMAN	pH-dependent, voltage-insensitive, background potassium channel protein. {ECO 0000269|PubMed 11042359, ECO 0000269|PubMed 11431495, ECO 0000269|PubMed 23169818}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0008021	synaptic vesicle; IEA:Ensembl.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IEA:Ensembl.
# GO_function	GO:0005267	potassium channel activity; TAS:Reactome.
# GO_function	GO:0022841	potassium ion leak channel activity; IBA:GO_Central.
# GO_process	GO:0006813	potassium ion transport; NAS:UniProtKB.
# GO_process	GO:0030322	stabilization of membrane potential; IBA:GO_Central.
# GO_process	GO:0071805	potassium ion transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9NPC2	HS
# HGNC	HGNC:6283	KCNK9
# InterPro	IPR003092	2pore_dom_K_chnl_TASK
# InterPro	IPR003280	2pore_dom_K_chnl
# InterPro	IPR005407	KCNK9
# InterPro	IPR013099	K_chnl_dom
# KEGG_Brite	ko04040	Ion channels
# KEGG_Disease	H00709	[Developmental disorder; Mental retardation] Birk-Barel syndrome (BIBAS)
# MIM	605874	gene
# MIM	612292	phenotype
# MISCELLANEOUS	KCNK9_HUMAN	Inhibited by phorbol 12-myristate 13-acetate (PMA). TASK-3 current is strongly decreased in the presence of an extracellular pH inferior to 7.0. 
# MISCELLANEOUS	KCNK9_HUMAN	Overexpressed in a high proportion of breast cancers. May confer resistance to growth factor deprivation and hypoxia, thereby promoting tumor cell survival in poorly oxygenated areas of solid tumors. 
# Organism	KCNK9_HUMAN	Homo sapiens (Human)
# Orphanet	166108	Intellectual disability, Birk-Barel type
# PDB	3P1N	X-ray; 1.40 A; P=369-374
# PDB	3P1O	X-ray; 1.90 A; P=369-374
# PDB	3P1P	X-ray; 1.95 A; P=369-374
# PDB	3P1Q	X-ray; 1.70 A; P=369-374
# PDB	3P1R	X-ray; 1.70 A; P=369-374
# PDB	3P1S	X-ray; 1.65 A; P=369-374
# PDB	3SMK	X-ray; 2.10 A; P=369-374
# PDB	3SML	X-ray; 1.90 A; P=370-374
# PDB	3SMM	X-ray; 2.00 A; P=369-374
# PDB	3SMN	X-ray; 2.00 A; P=369-374
# PDB	3SMO	X-ray; 1.80 A; P=369-374
# PDB	3SP5	X-ray; 1.80 A; P=369-374
# PDB	3SPR	X-ray; 1.99 A; P=369-374
# PDB	3UX0	X-ray; 1.75 A; P=369-374
# PDB	4FR3	X-ray; 1.90 A; P=369-374
# PIRSF	PIRSF038061	K_channel_subfamily_K_type
# PRINTS	PR01095	TASKCHANNEL
# PRINTS	PR01333	2POREKCHANEL
# PRINTS	PR01585	TASK3CHANNEL
# Pfam	PF07885	Ion_trans_2; 2
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-1299316	TWIK-releated acid-sensitive K+ channel (TASK)
# Reactome	R-HSA-5576886	Phase 4 - resting membrane potential
# RecName	KCNK9_HUMAN	Potassium channel subfamily K member 9
# RefSeq	NP_001269463	NM_001282534.1
# RefSeq	XP_011515404	XM_011517102.2
# SIMILARITY	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCNK9_HUMAN	Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUBUNIT	Homodimer (Probable). Heterodimer with KCNK1. {ECO:0000269|PubMed	23169818, ECO:0000305}. 
# TCDB	1.A.1.9.11	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	KCNK9_HUMAN	Mainly found in the cerebellum. Also found in adrenal gland, kidney and lung. {ECO 0000269|PubMed 11042359, ECO 0000269|PubMed 11431495}. 
# UCSC	uc003yvg	human
# eggNOG	ENOG410XRZJ	LUCA
# eggNOG	KOG4404	Eukaryota
BLAST	swissprot:KCNK9_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNK9_HUMAN
BioCyc	ZFISH:ENSG00000169427-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000169427-MONOMER
COXPRESdb	51305	http://coxpresdb.jp/data/gene/51305.shtml
CleanEx	HS_KCNK9	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNK9
DOI	10.1016/S0169-328X(00)00183-2	http://dx.doi.org/10.1016/S0169-328X(00)00183-2
DOI	10.1016/S1535-6108(03)00054-0	http://dx.doi.org/10.1016/S1535-6108(03)00054-0
DOI	10.1016/j.ajhg.2008.07.010	http://dx.doi.org/10.1016/j.ajhg.2008.07.010
DOI	10.1074/jbc.M000030200	http://dx.doi.org/10.1074/jbc.M000030200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2003431	http://dx.doi.org/10.1126/scisignal.2003431
DrugBank	DB00561	http://www.drugbank.ca/drugs/DB00561
DrugBank	DB01159	http://www.drugbank.ca/drugs/DB01159
EMBL	AF212829	http://www.ebi.ac.uk/ena/data/view/AF212829
EMBL	AF248241	http://www.ebi.ac.uk/ena/data/view/AF248241
EMBL	AF257080	http://www.ebi.ac.uk/ena/data/view/AF257080
EMBL	AF279809	http://www.ebi.ac.uk/ena/data/view/AF279809
EMBL	AY190605	http://www.ebi.ac.uk/ena/data/view/AY190605
EMBL	BC075079	http://www.ebi.ac.uk/ena/data/view/BC075079
EMBL	BC075080	http://www.ebi.ac.uk/ena/data/view/BC075080
EMBL	BC112063	http://www.ebi.ac.uk/ena/data/view/BC112063
EMBL	BC112065	http://www.ebi.ac.uk/ena/data/view/BC112065
Ensembl	ENST00000303015	http://www.ensembl.org/id/ENST00000303015
Ensembl	ENST00000520439	http://www.ensembl.org/id/ENST00000520439
Ensembl	ENST00000522317	http://www.ensembl.org/id/ENST00000522317
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0008021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008021
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_function	GO:0022841	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022841
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0030322	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030322
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	KCNK9	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNK9
GeneID	51305	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51305
GeneTree	ENSGT00760000118858	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118858
HGNC	HGNC:6283	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6283
HOGENOM	HOG000231463	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231463&db=HOGENOM6
HOVERGEN	HBG052239	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052239&db=HOVERGEN
HPA	HPA059318	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA059318
InParanoid	Q9NPC2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NPC2
InterPro	IPR003092	http://www.ebi.ac.uk/interpro/entry/IPR003092
InterPro	IPR003280	http://www.ebi.ac.uk/interpro/entry/IPR003280
InterPro	IPR005407	http://www.ebi.ac.uk/interpro/entry/IPR005407
InterPro	IPR013099	http://www.ebi.ac.uk/interpro/entry/IPR013099
Jabion	51305	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=51305
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00709	http://www.genome.jp/dbget-bin/www_bget?H00709
KEGG_Gene	hsa:51305	http://www.genome.jp/dbget-bin/www_bget?hsa:51305
KEGG_Orthology	KO:K04919	http://www.genome.jp/dbget-bin/www_bget?KO:K04919
MIM	605874	http://www.ncbi.nlm.nih.gov/omim/605874
MIM	612292	http://www.ncbi.nlm.nih.gov/omim/612292
OMA	NNDAENQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NNDAENQ
Orphanet	166108	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=166108
OrthoDB	EOG091G08DH	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08DH
PDB	3P1N	http://www.ebi.ac.uk/pdbe-srv/view/entry/3P1N
PDB	3P1O	http://www.ebi.ac.uk/pdbe-srv/view/entry/3P1O
PDB	3P1P	http://www.ebi.ac.uk/pdbe-srv/view/entry/3P1P
PDB	3P1Q	http://www.ebi.ac.uk/pdbe-srv/view/entry/3P1Q
PDB	3P1R	http://www.ebi.ac.uk/pdbe-srv/view/entry/3P1R
PDB	3P1S	http://www.ebi.ac.uk/pdbe-srv/view/entry/3P1S
PDB	3SMK	http://www.ebi.ac.uk/pdbe-srv/view/entry/3SMK
PDB	3SML	http://www.ebi.ac.uk/pdbe-srv/view/entry/3SML
PDB	3SMM	http://www.ebi.ac.uk/pdbe-srv/view/entry/3SMM
PDB	3SMN	http://www.ebi.ac.uk/pdbe-srv/view/entry/3SMN
PDB	3SMO	http://www.ebi.ac.uk/pdbe-srv/view/entry/3SMO
PDB	3SP5	http://www.ebi.ac.uk/pdbe-srv/view/entry/3SP5
PDB	3SPR	http://www.ebi.ac.uk/pdbe-srv/view/entry/3SPR
PDB	3UX0	http://www.ebi.ac.uk/pdbe-srv/view/entry/3UX0
PDB	4FR3	http://www.ebi.ac.uk/pdbe-srv/view/entry/4FR3
PDBsum	3P1N	http://www.ebi.ac.uk/pdbsum/3P1N
PDBsum	3P1O	http://www.ebi.ac.uk/pdbsum/3P1O
PDBsum	3P1P	http://www.ebi.ac.uk/pdbsum/3P1P
PDBsum	3P1Q	http://www.ebi.ac.uk/pdbsum/3P1Q
PDBsum	3P1R	http://www.ebi.ac.uk/pdbsum/3P1R
PDBsum	3P1S	http://www.ebi.ac.uk/pdbsum/3P1S
PDBsum	3SMK	http://www.ebi.ac.uk/pdbsum/3SMK
PDBsum	3SML	http://www.ebi.ac.uk/pdbsum/3SML
PDBsum	3SMM	http://www.ebi.ac.uk/pdbsum/3SMM
PDBsum	3SMN	http://www.ebi.ac.uk/pdbsum/3SMN
PDBsum	3SMO	http://www.ebi.ac.uk/pdbsum/3SMO
PDBsum	3SP5	http://www.ebi.ac.uk/pdbsum/3SP5
PDBsum	3SPR	http://www.ebi.ac.uk/pdbsum/3SPR
PDBsum	3UX0	http://www.ebi.ac.uk/pdbsum/3UX0
PDBsum	4FR3	http://www.ebi.ac.uk/pdbsum/4FR3
PRINTS	PR01095	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01095
PRINTS	PR01333	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01333
PRINTS	PR01585	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01585
PSORT	swissprot:KCNK9_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNK9_HUMAN
PSORT-B	swissprot:KCNK9_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNK9_HUMAN
PSORT2	swissprot:KCNK9_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNK9_HUMAN
Pfam	PF07885	http://pfam.xfam.org/family/PF07885
PharmGKB	PA30065	http://www.pharmgkb.org/do/serve?objId=PA30065&objCls=Gene
Phobius	swissprot:KCNK9_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNK9_HUMAN
PhylomeDB	Q9NPC2	http://phylomedb.org/?seqid=Q9NPC2
ProteinModelPortal	Q9NPC2	http://www.proteinmodelportal.org/query/uniprot/Q9NPC2
PubMed	10747866	http://www.ncbi.nlm.nih.gov/pubmed/10747866
PubMed	11042359	http://www.ncbi.nlm.nih.gov/pubmed/11042359
PubMed	11431495	http://www.ncbi.nlm.nih.gov/pubmed/11431495
PubMed	12676587	http://www.ncbi.nlm.nih.gov/pubmed/12676587
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18678320	http://www.ncbi.nlm.nih.gov/pubmed/18678320
PubMed	23169818	http://www.ncbi.nlm.nih.gov/pubmed/23169818
Reactome	R-HSA-1299316	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1299316
Reactome	R-HSA-5576886	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576886
RefSeq	NP_001269463	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269463
RefSeq	XP_011515404	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011515404
SMR	Q9NPC2	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9NPC2
STRING	9606.ENSP00000302166	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000302166&targetmode=cogs
TCDB	1.A.1.9.11	http://www.tcdb.org/search/result.php?tc=1.A.1.9.11
UCSC	uc003yvg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003yvg&org=rat
UniGene	Hs.493037	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.493037
UniGene	Hs.553147	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.553147
UniGene	Hs.664608	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.664608
UniProtKB	KCNK9_HUMAN	http://www.uniprot.org/uniprot/KCNK9_HUMAN
UniProtKB-AC	Q9NPC2	http://www.uniprot.org/uniprot/Q9NPC2
charge	swissprot:KCNK9_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNK9_HUMAN
eggNOG	ENOG410XRZJ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRZJ
eggNOG	KOG4404	http://eggnogapi.embl.de/nog_data/html/tree/KOG4404
epestfind	swissprot:KCNK9_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNK9_HUMAN
garnier	swissprot:KCNK9_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNK9_HUMAN
helixturnhelix	swissprot:KCNK9_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNK9_HUMAN
hmoment	swissprot:KCNK9_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNK9_HUMAN
iep	swissprot:KCNK9_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNK9_HUMAN
inforesidue	swissprot:KCNK9_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNK9_HUMAN
neXtProt	NX_Q9NPC2	http://www.nextprot.org/db/entry/NX_Q9NPC2
octanol	swissprot:KCNK9_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNK9_HUMAN
pepcoil	swissprot:KCNK9_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNK9_HUMAN
pepdigest	swissprot:KCNK9_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNK9_HUMAN
pepinfo	swissprot:KCNK9_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNK9_HUMAN
pepnet	swissprot:KCNK9_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNK9_HUMAN
pepstats	swissprot:KCNK9_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNK9_HUMAN
pepwheel	swissprot:KCNK9_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNK9_HUMAN
pepwindow	swissprot:KCNK9_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNK9_HUMAN
sigcleave	swissprot:KCNK9_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNK9_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ASIC4_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q96FT7-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q96FT7-2; Sequence=VSP_015609, VSP_015610; Note=No experimental confirmation available.; Name=3; IsoId=Q96FT7-4; Sequence=VSP_015611; 
# AltName	ASIC4_HUMAN	Amiloride-sensitive cation channel 4
# AltName	ASIC4_HUMAN	Amiloride-sensitive cation channel 4, pituitary
# BioGrid	120693	40
# CCDS	CCDS2442	-. [Q96FT7-1]
# ChiTaRS	ASIC4	human
# Ensembl	ENST00000347842	ENSP00000326627; ENSG00000072182. [Q96FT7-1]
# Ensembl	ENST00000358078	ENSP00000350786; ENSG00000072182. [Q96FT7-4]
# FUNCTION	ASIC4_HUMAN	Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity. {ECO 0000269|PubMed 10852210}. 
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_function	GO:0005216	ion channel activity; TAS:ProtInc.
# GO_function	GO:0005272	sodium channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0015081	sodium ion transmembrane transporter activity; TAS:ProtInc.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q96FT7	HS
# HGNC	HGNC:21263	ASIC4
# IntAct	Q96FT7	2
# InterPro	IPR001873	Na+channel_ASC
# InterPro	IPR020903	Na+channel_ASC_CS
# KEGG_Brite	ko04040	Ion channels
# MIM	606715	gene
# Organism	ASIC4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11690	PTHR11690
# PRINTS	PR01078	AMINACHANNEL
# PROSITE	PS01206	ASC
# Pfam	PF00858	ASC
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	ASIC4_HUMAN	Acid-sensing ion channel 4
# RefSeq	NP_061144	NM_018674.5
# RefSeq	NP_878267	NM_182847.2. [Q96FT7-1]
# SEQUENCE CAUTION	Sequence=CAB93980.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAC51338.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC4 subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	ASIC4_HUMAN	Membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUBUNIT	Homotrimer or heterotrimer with other ASIC proteins. {ECO	0000250}. 
# TISSUE SPECIFICITY	Expressed in pituitary gland. Weakly expressed in brain, vestibular system and organ of Corti. {ECO:0000269|PubMed	10852210}. 
# UCSC	uc002vma	human. [Q96FT7-1]
# eggNOG	ENOG410ZNFK	LUCA
# eggNOG	KOG4294	Eukaryota
BLAST	swissprot:ASIC4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ASIC4_HUMAN
COXPRESdb	55515	http://coxpresdb.jp/data/gene/55515.shtml
CleanEx	HS_ACCN4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ACCN4
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/sj.ejhg.5200699	http://dx.doi.org/10.1038/sj.ejhg.5200699
DOI	10.1097/00001756-200006050-00003	http://dx.doi.org/10.1097/00001756-200006050-00003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC009955	http://www.ebi.ac.uk/ena/data/view/AC009955
EMBL	AC053503	http://www.ebi.ac.uk/ena/data/view/AC053503
EMBL	AC139723	http://www.ebi.ac.uk/ena/data/view/AC139723
EMBL	AJ271643	http://www.ebi.ac.uk/ena/data/view/AJ271643
EMBL	AJ408881	http://www.ebi.ac.uk/ena/data/view/AJ408881
EMBL	AJ408882	http://www.ebi.ac.uk/ena/data/view/AJ408882
EMBL	AJ408883	http://www.ebi.ac.uk/ena/data/view/AJ408883
EMBL	AJ408884	http://www.ebi.ac.uk/ena/data/view/AJ408884
EMBL	BC010439	http://www.ebi.ac.uk/ena/data/view/BC010439
EMBL	BC031812	http://www.ebi.ac.uk/ena/data/view/BC031812
Ensembl	ENST00000347842	http://www.ensembl.org/id/ENST00000347842
Ensembl	ENST00000358078	http://www.ensembl.org/id/ENST00000358078
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005216	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005216
GO_function	GO:0005272	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005272
GO_function	GO:0015081	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015081
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	ASIC4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ASIC4
GeneID	55515	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55515
GeneTree	ENSGT00760000119120	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119120
H-InvDB	HIX0002867	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0002867
HGNC	HGNC:21263	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:21263
HOGENOM	HOG000247010	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000247010&db=HOGENOM6
HOVERGEN	HBG004150	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004150&db=HOVERGEN
HPA	CAB032529	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB032529
HPA	HPA036042	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA036042
InParanoid	Q96FT7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96FT7
IntAct	Q96FT7	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96FT7*
InterPro	IPR001873	http://www.ebi.ac.uk/interpro/entry/IPR001873
InterPro	IPR020903	http://www.ebi.ac.uk/interpro/entry/IPR020903
Jabion	55515	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55515
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:55515	http://www.genome.jp/dbget-bin/www_bget?hsa:55515
KEGG_Orthology	KO:K04831	http://www.genome.jp/dbget-bin/www_bget?KO:K04831
MIM	606715	http://www.ncbi.nlm.nih.gov/omim/606715
OMA	QHQGCGA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QHQGCGA
OrthoDB	EOG091G053J	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G053J
PANTHER	PTHR11690	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11690
PRINTS	PR01078	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01078
PROSITE	PS01206	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01206
PSORT	swissprot:ASIC4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ASIC4_HUMAN
PSORT-B	swissprot:ASIC4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ASIC4_HUMAN
PSORT2	swissprot:ASIC4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ASIC4_HUMAN
Pfam	PF00858	http://pfam.xfam.org/family/PF00858
PharmGKB	PA134956731	http://www.pharmgkb.org/do/serve?objId=PA134956731&objCls=Gene
Phobius	swissprot:ASIC4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ASIC4_HUMAN
PhylomeDB	Q96FT7	http://phylomedb.org/?seqid=Q96FT7
ProteinModelPortal	Q96FT7	http://www.proteinmodelportal.org/query/uniprot/Q96FT7
PubMed	10852210	http://www.ncbi.nlm.nih.gov/pubmed/10852210
PubMed	11571555	http://www.ncbi.nlm.nih.gov/pubmed/11571555
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_061144	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061144
RefSeq	NP_878267	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_878267
SMR	Q96FT7	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q96FT7
STRING	9606.ENSP00000326627	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000326627&targetmode=cogs
UCSC	uc002vma	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002vma&org=rat
UniGene	Hs.87469	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.87469
UniProtKB	ASIC4_HUMAN	http://www.uniprot.org/uniprot/ASIC4_HUMAN
UniProtKB-AC	Q96FT7	http://www.uniprot.org/uniprot/Q96FT7
charge	swissprot:ASIC4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ASIC4_HUMAN
eggNOG	ENOG410ZNFK	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZNFK
eggNOG	KOG4294	http://eggnogapi.embl.de/nog_data/html/tree/KOG4294
epestfind	swissprot:ASIC4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ASIC4_HUMAN
garnier	swissprot:ASIC4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ASIC4_HUMAN
helixturnhelix	swissprot:ASIC4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ASIC4_HUMAN
hmoment	swissprot:ASIC4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ASIC4_HUMAN
iep	swissprot:ASIC4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ASIC4_HUMAN
inforesidue	swissprot:ASIC4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ASIC4_HUMAN
neXtProt	NX_Q96FT7	http://www.nextprot.org/db/entry/NX_Q96FT7
octanol	swissprot:ASIC4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ASIC4_HUMAN
pepcoil	swissprot:ASIC4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ASIC4_HUMAN
pepdigest	swissprot:ASIC4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ASIC4_HUMAN
pepinfo	swissprot:ASIC4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ASIC4_HUMAN
pepnet	swissprot:ASIC4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ASIC4_HUMAN
pepstats	swissprot:ASIC4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ASIC4_HUMAN
pepwheel	swissprot:ASIC4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ASIC4_HUMAN
pepwindow	swissprot:ASIC4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ASIC4_HUMAN
sigcleave	swissprot:ASIC4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ASIC4_HUMAN
## Database	ID	URL or Descriptions
# AltName	ADT1_HUMAN	ADP,ATP carrier protein 1
# AltName	ADT1_HUMAN	ADP,ATP carrier protein, heart/skeletal muscle isoform T1
# AltName	ADT1_HUMAN	Adenine nucleotide translocator 1
# AltName	ADT1_HUMAN	Solute carrier family 25 member 4
# BioGrid	106788	42
# ChiTaRS	SLC25A4	human
# DISEASE	ADT1_HUMAN	Mitochondrial DNA depletion syndrome 12, cardiomyopathic type (MTDPS12) [MIM 615418]  An autosomal recessive mitochondrial disorder characterized by childhood onset of slowly progressive hypertrophic cardiomyopathy and generalized skeletal myopathy resulting in exercise intolerance and, in some patients, muscle weakness and atrophy. Skeletal muscle biopsy shows ragged red fibers, mtDNA depletion, and accumulation of abnormal mitochondria. {ECO 0000269|PubMed 22187496}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ADT1_HUMAN	Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 2 (PEOA2) [MIM 609283]  A disorder characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged-red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism. {ECO 0000269|PubMed 10926541, ECO 0000269|PubMed 11756613, ECO 0000269|PubMed 12112115, ECO 0000269|PubMed 15792871, ECO 0000269|PubMed 18575922}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00171	Adenosine triphosphate
# DrugBank	DB00720	Clodronate
# Ensembl	ENST00000281456	ENSP00000281456; ENSG00000151729
# ExpressionAtlas	P12235	baseline and differential
# FUNCTION	ADT1_HUMAN	Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. 
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0043209	myelin sheath; IEA:Ensembl.
# GO_function	GO:0015207	adenine transmembrane transporter activity; TAS:ProtInc.
# GO_process	GO:0000002	mitochondrial genome maintenance; TAS:ProtInc.
# GO_process	GO:0006091	generation of precursor metabolites and energy; TAS:ProtInc.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0008637	apoptotic mitochondrial changes; IEA:Ensembl.
# GO_process	GO:0016032	viral process; IEA:UniProtKB-KW.
# GO_process	GO:0050796	regulation of insulin secretion; TAS:Reactome.
# GO_process	GO:0060546	negative regulation of necroptotic process; IMP:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005739	mitochondrion
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007005	mitochondrion organization
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# Gene3D	1.50.40.10	-; 1.
# Genevisible	P12235	HS
# HGNC	HGNC:10990	SLC25A4
# INTERACTION	ADT1_HUMAN	Q5S007 LRRK2; NbExp=2; IntAct=EBI-359074, EBI-5323863; 
# IntAct	P12235	20
# InterPro	IPR002067	Mit_carrier
# InterPro	IPR002113	Aden_trnslctor
# InterPro	IPR018108	Mitochondrial_sb/sol_carrier
# InterPro	IPR023395	Mt_carrier_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H00469	[Inherited metabolic disease; Mitochondrial disease] Mitochondrial DNA depletion syndrome (MDS)
# KEGG_Disease	H01118	[Nervous system disease; Musculoskeletal disease; Eye disease; Inherited metabolic disease] Progressive external ophthalmoplegia (PEO)
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# KEGG_Pathway	ko05166	HTLV-I infection
# MIM	103220	gene
# MIM	609283	phenotype
# MIM	615418	phenotype
# MISCELLANEOUS	The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity). {ECO	0000250}. 
# Organism	ADT1_HUMAN	Homo sapiens (Human)
# Orphanet	1369	Congenital cataract - hypertrophic cardiomyopathy - mitochondrial myopathy
# Orphanet	155	Familial isolated hypertrophic cardiomyopathy
# Orphanet	254892	Autosomal dominant progressive external ophthalmoplegia
# PIR	A44778	A44778
# PRINTS	PR00926	MITOCARRIER
# PRINTS	PR00927	ADPTRNSLCASE
# PROSITE	PS50920	SOLCAR; 3
# Pfam	PF00153	Mito_carr; 3
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-1268020	Mitochondrial protein import
# Reactome	R-HSA-180897	Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
# Reactome	R-HSA-422356	Regulation of insulin secretion
# RecName	ADT1_HUMAN	ADP/ATP translocase 1
# RefSeq	NP_001142	NM_001151.3
# SIMILARITY	Belongs to the mitochondrial carrier (TC 2.A.29) family. {ECO	0000305}. 
# SIMILARITY	Contains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule	PRU00282}.
# SUBCELLULAR LOCATION	ADT1_HUMAN	Mitochondrion inner membrane; Multi-pass membrane protein. 
# SUBUNIT	Found in a complex with ARL2, ARL2BP and SLC25A4. Interacts with ARL2BP (By similarity). Homodimer. Interacts with HIV-1 Vpr. {ECO:0000250, ECO	0000269|PubMed:16120388}. 
# SUPFAM	SSF103506	SSF103506
# TCDB	2.A.29.1	the mitochondrial carrier (mc) family
# UCSC	uc003ixd	human
# eggNOG	ENOG410XNW0	LUCA
# eggNOG	KOG0749	Eukaryota
BLAST	swissprot:ADT1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ADT1_HUMAN
BioCyc	ZFISH:ENSG00000151729-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000151729-MONOMER
COXPRESdb	291	http://coxpresdb.jp/data/gene/291.shtml
CleanEx	HS_SLC25A4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC25A4
DIP	DIP-33116N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-33116N
DOI	10.1002/ana.10172	http://dx.doi.org/10.1002/ana.10172
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1007/s00415-008-0926-3	http://dx.doi.org/10.1007/s00415-008-0926-3
DOI	10.1016/0022-2836(89)90477-4	http://dx.doi.org/10.1016/0022-2836(89)90477-4
DOI	10.1016/j.mito.2004.06.012	http://dx.doi.org/10.1016/j.mito.2004.06.012
DOI	10.1016/j.nmd.2004.12.004	http://dx.doi.org/10.1016/j.nmd.2004.12.004
DOI	10.1073/pnas.84.21.7580	http://dx.doi.org/10.1073/pnas.84.21.7580
DOI	10.1073/pnas.85.2.377	http://dx.doi.org/10.1073/pnas.85.2.377
DOI	10.1093/hmg/ddi341	http://dx.doi.org/10.1093/hmg/ddi341
DOI	10.1093/nar/gkq750	http://dx.doi.org/10.1093/nar/gkq750
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1126/science.289.5480.782	http://dx.doi.org/10.1126/science.289.5480.782
DOI	10.1136/jmedgenet-2011-100504	http://dx.doi.org/10.1136/jmedgenet-2011-100504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1212/01.WNL.0000056088.09408.3C	http://dx.doi.org/10.1212/01.WNL.0000056088.09408.3C
DOI	10.1212/WNL.57.12.2295	http://dx.doi.org/10.1212/WNL.57.12.2295
DrugBank	DB00171	http://www.drugbank.ca/drugs/DB00171
DrugBank	DB00720	http://www.drugbank.ca/drugs/DB00720
EMBL	BC008664	http://www.ebi.ac.uk/ena/data/view/BC008664
EMBL	BC061589	http://www.ebi.ac.uk/ena/data/view/BC061589
EMBL	BC063643	http://www.ebi.ac.uk/ena/data/view/BC063643
EMBL	CH471056	http://www.ebi.ac.uk/ena/data/view/CH471056
EMBL	CH471056	http://www.ebi.ac.uk/ena/data/view/CH471056
EMBL	HQ206346	http://www.ebi.ac.uk/ena/data/view/HQ206346
EMBL	HQ206347	http://www.ebi.ac.uk/ena/data/view/HQ206347
EMBL	HQ206348	http://www.ebi.ac.uk/ena/data/view/HQ206348
EMBL	HQ206349	http://www.ebi.ac.uk/ena/data/view/HQ206349
EMBL	HQ206350	http://www.ebi.ac.uk/ena/data/view/HQ206350
EMBL	HQ206351	http://www.ebi.ac.uk/ena/data/view/HQ206351
EMBL	HQ206352	http://www.ebi.ac.uk/ena/data/view/HQ206352
EMBL	HQ206353	http://www.ebi.ac.uk/ena/data/view/HQ206353
EMBL	HQ206354	http://www.ebi.ac.uk/ena/data/view/HQ206354
EMBL	HQ206355	http://www.ebi.ac.uk/ena/data/view/HQ206355
EMBL	HQ206356	http://www.ebi.ac.uk/ena/data/view/HQ206356
EMBL	HQ206357	http://www.ebi.ac.uk/ena/data/view/HQ206357
EMBL	HQ206358	http://www.ebi.ac.uk/ena/data/view/HQ206358
EMBL	HQ206359	http://www.ebi.ac.uk/ena/data/view/HQ206359
EMBL	HQ206360	http://www.ebi.ac.uk/ena/data/view/HQ206360
EMBL	HQ206361	http://www.ebi.ac.uk/ena/data/view/HQ206361
EMBL	HQ206362	http://www.ebi.ac.uk/ena/data/view/HQ206362
EMBL	HQ206363	http://www.ebi.ac.uk/ena/data/view/HQ206363
EMBL	HQ206364	http://www.ebi.ac.uk/ena/data/view/HQ206364
EMBL	HQ206365	http://www.ebi.ac.uk/ena/data/view/HQ206365
EMBL	HQ206366	http://www.ebi.ac.uk/ena/data/view/HQ206366
EMBL	HQ206367	http://www.ebi.ac.uk/ena/data/view/HQ206367
EMBL	HQ206368	http://www.ebi.ac.uk/ena/data/view/HQ206368
EMBL	HQ206369	http://www.ebi.ac.uk/ena/data/view/HQ206369
EMBL	HQ206370	http://www.ebi.ac.uk/ena/data/view/HQ206370
EMBL	HQ206371	http://www.ebi.ac.uk/ena/data/view/HQ206371
EMBL	HQ206372	http://www.ebi.ac.uk/ena/data/view/HQ206372
EMBL	HQ206373	http://www.ebi.ac.uk/ena/data/view/HQ206373
EMBL	HQ206374	http://www.ebi.ac.uk/ena/data/view/HQ206374
EMBL	HQ206375	http://www.ebi.ac.uk/ena/data/view/HQ206375
EMBL	HQ206376	http://www.ebi.ac.uk/ena/data/view/HQ206376
EMBL	HQ206377	http://www.ebi.ac.uk/ena/data/view/HQ206377
EMBL	HQ206378	http://www.ebi.ac.uk/ena/data/view/HQ206378
EMBL	HQ206379	http://www.ebi.ac.uk/ena/data/view/HQ206379
EMBL	HQ206380	http://www.ebi.ac.uk/ena/data/view/HQ206380
EMBL	HQ206381	http://www.ebi.ac.uk/ena/data/view/HQ206381
EMBL	HQ206382	http://www.ebi.ac.uk/ena/data/view/HQ206382
EMBL	HQ206383	http://www.ebi.ac.uk/ena/data/view/HQ206383
EMBL	HQ206384	http://www.ebi.ac.uk/ena/data/view/HQ206384
EMBL	HQ206385	http://www.ebi.ac.uk/ena/data/view/HQ206385
EMBL	J02966	http://www.ebi.ac.uk/ena/data/view/J02966
EMBL	J03593	http://www.ebi.ac.uk/ena/data/view/J03593
EMBL	J04982	http://www.ebi.ac.uk/ena/data/view/J04982
Ensembl	ENST00000281456	http://www.ensembl.org/id/ENST00000281456
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0043209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043209
GO_function	GO:0015207	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015207
GO_process	GO:0000002	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000002
GO_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0008637	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008637
GO_process	GO:0016032	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016032
GO_process	GO:0050796	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050796
GO_process	GO:0060546	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060546
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007005
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
Gene3D	1.50.40.10	http://www.cathdb.info/version/latest/superfamily/1.50.40.10
GeneCards	SLC25A4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC25A4
GeneID	291	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=291
GeneTree	ENSGT00390000011543	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000011543
HGNC	HGNC:10990	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10990
HOGENOM	HOG000165727	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000165727&db=HOGENOM6
HOVERGEN	HBG108348	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108348&db=HOVERGEN
HPA	HPA060665	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA060665
InParanoid	P12235	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P12235
IntAct	P12235	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P12235*
InterPro	IPR002067	http://www.ebi.ac.uk/interpro/entry/IPR002067
InterPro	IPR002113	http://www.ebi.ac.uk/interpro/entry/IPR002113
InterPro	IPR018108	http://www.ebi.ac.uk/interpro/entry/IPR018108
InterPro	IPR023395	http://www.ebi.ac.uk/interpro/entry/IPR023395
Jabion	291	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=291
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00469	http://www.genome.jp/dbget-bin/www_bget?H00469
KEGG_Disease	H01118	http://www.genome.jp/dbget-bin/www_bget?H01118
KEGG_Gene	hsa:291	http://www.genome.jp/dbget-bin/www_bget?hsa:291
KEGG_Orthology	KO:K05863	http://www.genome.jp/dbget-bin/www_bget?KO:K05863
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
KEGG_Pathway	ko05166	http://www.genome.jp/kegg-bin/show_pathway?ko05166
MIM	103220	http://www.ncbi.nlm.nih.gov/omim/103220
MIM	609283	http://www.ncbi.nlm.nih.gov/omim/609283
MIM	615418	http://www.ncbi.nlm.nih.gov/omim/615418
MINT	MINT-196037	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-196037
OMA	GSSQREF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GSSQREF
Orphanet	1369	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1369
Orphanet	155	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=155
Orphanet	254892	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=254892
OrthoDB	EOG091G0ULB	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0ULB
PRINTS	PR00926	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00926
PRINTS	PR00927	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00927
PROSITE	PS50920	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50920
PSORT	swissprot:ADT1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ADT1_HUMAN
PSORT-B	swissprot:ADT1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ADT1_HUMAN
PSORT2	swissprot:ADT1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ADT1_HUMAN
Pfam	PF00153	http://pfam.xfam.org/family/PF00153
PharmGKB	PA35866	http://www.pharmgkb.org/do/serve?objId=PA35866&objCls=Gene
Phobius	swissprot:ADT1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ADT1_HUMAN
PhylomeDB	P12235	http://phylomedb.org/?seqid=P12235
ProteinModelPortal	P12235	http://www.proteinmodelportal.org/query/uniprot/P12235
PubMed	10926541	http://www.ncbi.nlm.nih.gov/pubmed/10926541
PubMed	11756613	http://www.ncbi.nlm.nih.gov/pubmed/11756613
PubMed	12112115	http://www.ncbi.nlm.nih.gov/pubmed/12112115
PubMed	12707443	http://www.ncbi.nlm.nih.gov/pubmed/12707443
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15792871	http://www.ncbi.nlm.nih.gov/pubmed/15792871
PubMed	16120388	http://www.ncbi.nlm.nih.gov/pubmed/16120388
PubMed	16155110	http://www.ncbi.nlm.nih.gov/pubmed/16155110
PubMed	18575922	http://www.ncbi.nlm.nih.gov/pubmed/18575922
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	20843780	http://www.ncbi.nlm.nih.gov/pubmed/20843780
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22187496	http://www.ncbi.nlm.nih.gov/pubmed/22187496
PubMed	2541251	http://www.ncbi.nlm.nih.gov/pubmed/2541251
PubMed	2547778	http://www.ncbi.nlm.nih.gov/pubmed/2547778
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	2823266	http://www.ncbi.nlm.nih.gov/pubmed/2823266
PubMed	2829183	http://www.ncbi.nlm.nih.gov/pubmed/2829183
Reactome	R-HSA-1268020	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1268020
Reactome	R-HSA-180897	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-180897
Reactome	R-HSA-422356	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-422356
RefSeq	NP_001142	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001142
SMR	P12235	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P12235
STRING	9606.ENSP00000281456	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000281456&targetmode=cogs
SUPFAM	SSF103506	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103506
TCDB	2.A.29.1	http://www.tcdb.org/search/result.php?tc=2.A.29.1
UCSC	uc003ixd	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ixd&org=rat
UniGene	Hs.246506	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.246506
UniProtKB	ADT1_HUMAN	http://www.uniprot.org/uniprot/ADT1_HUMAN
UniProtKB-AC	P12235	http://www.uniprot.org/uniprot/P12235
charge	swissprot:ADT1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ADT1_HUMAN
eggNOG	ENOG410XNW0	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNW0
eggNOG	KOG0749	http://eggnogapi.embl.de/nog_data/html/tree/KOG0749
epestfind	swissprot:ADT1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ADT1_HUMAN
garnier	swissprot:ADT1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ADT1_HUMAN
helixturnhelix	swissprot:ADT1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ADT1_HUMAN
hmoment	swissprot:ADT1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ADT1_HUMAN
iep	swissprot:ADT1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ADT1_HUMAN
inforesidue	swissprot:ADT1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ADT1_HUMAN
neXtProt	NX_P12235	http://www.nextprot.org/db/entry/NX_P12235
octanol	swissprot:ADT1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ADT1_HUMAN
pepcoil	swissprot:ADT1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ADT1_HUMAN
pepdigest	swissprot:ADT1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ADT1_HUMAN
pepinfo	swissprot:ADT1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ADT1_HUMAN
pepnet	swissprot:ADT1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ADT1_HUMAN
pepstats	swissprot:ADT1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ADT1_HUMAN
pepwheel	swissprot:ADT1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ADT1_HUMAN
pepwindow	swissprot:ADT1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ADT1_HUMAN
sigcleave	swissprot:ADT1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ADT1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CLCN7_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P51798-1; Sequence=Displayed; Name=2; IsoId=P51798-2; Sequence=VSP_045698; Note=No experimental confirmation available.; 
# AltName	CLCN7_HUMAN	Chloride channel 7 alpha subunit
# AltName	CLCN7_HUMAN	Chloride channel protein 7
# BioGrid	107600	34
# CCDS	CCDS32361	-. [P51798-1]
# CCDS	CCDS45378	-. [P51798-2]
# ChiTaRS	CLCN7	human
# DISEASE	CLCN7_HUMAN	Osteopetrosis, autosomal dominant 2 (OPTA2) [MIM 166600]  A rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. Osteopetrosis occurs in two forms  a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. OPTA2 is the most common form of osteopetrosis, occurring in adolescence or adulthood. It is characterized by sclerosis, predominantly involving the spine, the pelvis and the skull base. {ECO 0000269|PubMed 11741829, ECO 0000269|PubMed 14584882, ECO 0000269|PubMed 19288050, ECO 0000269|PubMed 19953639, ECO 0000269|PubMed 26395888}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CLCN7_HUMAN	Osteopetrosis, autosomal recessive 2 (OPTB2) [MIM 259710]  A rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. Osteopetrosis occurs in two forms  a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Recessive osteopetrosis commonly manifests in early infancy with macrocephaly, feeding difficulties, evolving blindness and deafness, bone marrow failure, severe anemia, and hepatosplenomegaly. Deafness and blindness are generally thought to represent effects of pressure on nerves. OPTB2 is characterized by paucity of osteoclasts, suggesting a molecular defect in osteoclast development. {ECO 0000269|PubMed 26395888}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CLCN7_HUMAN	Osteopetrosis, autosomal recessive 4 (OPTB4) [MIM 611490]  A rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. Osteopetrosis occurs in two forms  a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Recessive osteopetrosis commonly manifests in early infancy with macrocephaly, feeding difficulties, evolving blindness and deafness, bone marrow failure, severe anemia, and hepatosplenomegaly. Deafness and blindness are generally thought to represent effects of pressure on nerves. {ECO 0000269|PubMed 11207362, ECO 0000269|PubMed 11741829, ECO 0000269|PubMed 14584882, ECO 0000269|PubMed 17033731, ECO 0000269|PubMed 19953639, ECO 0000269|PubMed 26477479}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000382745	ENSP00000372193; ENSG00000103249. [P51798-1]
# Ensembl	ENST00000448525	ENSP00000410907; ENSG00000103249. [P51798-2]
# ExpressionAtlas	P51798	baseline and differential
# FUNCTION	CLCN7_HUMAN	Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen. {ECO 0000269|PubMed 18449189, ECO 0000269|PubMed 21527911}. 
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0031410	cytoplasmic vesicle; IEA:Ensembl.
# GO_function	GO:0005247	voltage-gated chloride channel activity; IBA:GO_Central.
# GO_function	GO:0005254	chloride channel activity; TAS:ProtInc.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0015297	antiporter activity; IEA:UniProtKB-KW.
# GO_function	GO:0031404	chloride ion binding; IBA:GO_Central.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0009268	response to pH; IEA:Ensembl.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.10.3080.10	-; 2.
# Genevisible	P51798	HS
# HGNC	HGNC:2025	CLCN7
# IntAct	P51798	29
# InterPro	IPR000644	CBS_dom
# InterPro	IPR001807	Cl-channel_volt-gated
# InterPro	IPR002249	Cl_channel-7
# InterPro	IPR014743	Cl-channel_core
# KEGG_Brite	ko04040	Ion channels
# KEGG_Disease	H00436	[Skeletal dysplasia] Osteopetrosis, osteoclast poor
# MIM	166600	phenotype
# MIM	259710	phenotype
# MIM	602727	gene
# MIM	611490	phenotype
# MISCELLANEOUS	The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {ECO	0000250}. 
# Organism	CLCN7_HUMAN	Homo sapiens (Human)
# Orphanet	210110	Intermediate osteopetrosis
# Orphanet	53	Albers-Schonberg osteopetrosis
# Orphanet	667	Autosomal recessive malignant osteopetrosis
# PIR	S68427	S68427
# PRINTS	PR00762	CLCHANNEL
# PRINTS	PR01118	CLCHANNEL7
# PROSITE	PS51371	CBS; 2
# Pfam	PF00571	CBS; 2
# Pfam	PF00654	Voltage_CLC
# Proteomes	UP000005640	Chromosome 16
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	CLCN7_HUMAN	H(+)/Cl(-) exchange transporter 7
# RefSeq	NP_001107803	NM_001114331.2. [P51798-2]
# RefSeq	NP_001278	NM_001287.5. [P51798-1]
# SIMILARITY	Belongs to the chloride channel (TC 2.A.49) family. ClC-7/CLCN7 subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 2 CBS domains. {ECO:0000255|PROSITE- ProRule	PRU00703}.
# SMART	SM00116	CBS; 2
# SUBCELLULAR LOCATION	CLCN7_HUMAN	Lysosome membrane {ECO 0000269|PubMed 17897319, ECO 0000269|PubMed 18449189, ECO 0000269|PubMed 21527911}; Multi-pass membrane protein {ECO 0000269|PubMed 17897319, ECO 0000269|PubMed 18449189, ECO 0000269|PubMed 21527911}. 
# SUBUNIT	Chloride channel 7 are heteromers of alpha (CLCN7) and beta (OSTM1) subunits. {ECO:0000269|PubMed	21527911}. 
# SUPFAM	SSF81340	SSF81340; 2
# TCDB	2.A.49.3	the chloride carrier/channel (clc) family
# TISSUE SPECIFICITY	CLCN7_HUMAN	Brain, testis, muscle and kidney. 
# UCSC	uc002clv	human. [P51798-1]
# eggNOG	COG0038	LUCA
# eggNOG	KOG0474	Eukaryota
BLAST	swissprot:CLCN7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CLCN7_HUMAN
BioCyc	ZFISH:ENSG00000103249-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000103249-MONOMER
COXPRESdb	1186	http://coxpresdb.jp/data/gene/1186.shtml
CleanEx	HS_CLCN7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CLCN7
DOI	10.1002/humu.21167	http://dx.doi.org/10.1002/humu.21167
DOI	10.1007/s00198-015-3320-x	http://dx.doi.org/10.1007/s00198-015-3320-x
DOI	10.1007/s00774-009-0051-0	http://dx.doi.org/10.1007/s00774-009-0051-0
DOI	10.1007/s10038-006-0075-4	http://dx.doi.org/10.1007/s10038-006-0075-4
DOI	10.1016/0014-5793(95)01298-2	http://dx.doi.org/10.1016/0014-5793(95)01298-2
DOI	10.1016/S0092-8674(01)00206-9	http://dx.doi.org/10.1016/S0092-8674(01)00206-9
DOI	10.1016/S0167-4781(98)00014-1	http://dx.doi.org/10.1016/S0167-4781(98)00014-1
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.gene.2015.10.021	http://dx.doi.org/10.1016/j.gene.2015.10.021
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/emboj.2011.137	http://dx.doi.org/10.1038/emboj.2011.137
DOI	10.1038/nature03187	http://dx.doi.org/10.1038/nature03187
DOI	10.1038/nature06907	http://dx.doi.org/10.1038/nature06907
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1093/hmg/10.25.2861	http://dx.doi.org/10.1093/hmg/10.25.2861
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1600-0854.2007.00643.x	http://dx.doi.org/10.1111/j.1600-0854.2007.00643.x
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1359/jbmr.2003.18.10.1740	http://dx.doi.org/10.1359/jbmr.2003.18.10.1740
EMBL	AF224741	http://www.ebi.ac.uk/ena/data/view/AF224741
EMBL	AJ001910	http://www.ebi.ac.uk/ena/data/view/AJ001910
EMBL	AK056551	http://www.ebi.ac.uk/ena/data/view/AK056551
EMBL	AK291404	http://www.ebi.ac.uk/ena/data/view/AK291404
EMBL	AK292136	http://www.ebi.ac.uk/ena/data/view/AK292136
EMBL	AL031600	http://www.ebi.ac.uk/ena/data/view/AL031600
EMBL	AL031705	http://www.ebi.ac.uk/ena/data/view/AL031705
EMBL	BC012737	http://www.ebi.ac.uk/ena/data/view/BC012737
EMBL	U88844	http://www.ebi.ac.uk/ena/data/view/U88844
EMBL	Z67743	http://www.ebi.ac.uk/ena/data/view/Z67743
Ensembl	ENST00000382745	http://www.ensembl.org/id/ENST00000382745
Ensembl	ENST00000448525	http://www.ensembl.org/id/ENST00000448525
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GO_function	GO:0005247	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005247
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0015297	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297
GO_function	GO:0031404	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031404
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0009268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009268
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.10.3080.10	http://www.cathdb.info/version/latest/superfamily/1.10.3080.10
GeneCards	CLCN7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CLCN7
GeneID	1186	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1186
GeneTree	ENSGT00760000119109	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119109
HGNC	HGNC:2025	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2025
HOGENOM	HOG000231081	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231081&db=HOGENOM6
HOVERGEN	HBG050985	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050985&db=HOVERGEN
HPA	HPA043019	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA043019
HPA	HPA043586	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA043586
InParanoid	P51798	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P51798
IntAct	P51798	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P51798*
InterPro	IPR000644	http://www.ebi.ac.uk/interpro/entry/IPR000644
InterPro	IPR001807	http://www.ebi.ac.uk/interpro/entry/IPR001807
InterPro	IPR002249	http://www.ebi.ac.uk/interpro/entry/IPR002249
InterPro	IPR014743	http://www.ebi.ac.uk/interpro/entry/IPR014743
Jabion	1186	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1186
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00436	http://www.genome.jp/dbget-bin/www_bget?H00436
KEGG_Gene	hsa:1186	http://www.genome.jp/dbget-bin/www_bget?hsa:1186
KEGG_Orthology	KO:K05016	http://www.genome.jp/dbget-bin/www_bget?KO:K05016
MIM	166600	http://www.ncbi.nlm.nih.gov/omim/166600
MIM	259710	http://www.ncbi.nlm.nih.gov/omim/259710
MIM	602727	http://www.ncbi.nlm.nih.gov/omim/602727
MIM	611490	http://www.ncbi.nlm.nih.gov/omim/611490
MINT	MINT-3019199	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3019199
Orphanet	210110	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=210110
Orphanet	53	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=53
Orphanet	667	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=667
PRINTS	PR00762	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00762
PRINTS	PR01118	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01118
PROSITE	PS51371	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51371
PSORT	swissprot:CLCN7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CLCN7_HUMAN
PSORT-B	swissprot:CLCN7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CLCN7_HUMAN
PSORT2	swissprot:CLCN7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CLCN7_HUMAN
Pfam	PF00571	http://pfam.xfam.org/family/PF00571
Pfam	PF00654	http://pfam.xfam.org/family/PF00654
PharmGKB	PA26552	http://www.pharmgkb.org/do/serve?objId=PA26552&objCls=Gene
Phobius	swissprot:CLCN7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CLCN7_HUMAN
PhylomeDB	P51798	http://phylomedb.org/?seqid=P51798
ProteinModelPortal	P51798	http://www.proteinmodelportal.org/query/uniprot/P51798
PubMed	11207362	http://www.ncbi.nlm.nih.gov/pubmed/11207362
PubMed	11741829	http://www.ncbi.nlm.nih.gov/pubmed/11741829
PubMed	14584882	http://www.ncbi.nlm.nih.gov/pubmed/14584882
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15616553	http://www.ncbi.nlm.nih.gov/pubmed/15616553
PubMed	17033731	http://www.ncbi.nlm.nih.gov/pubmed/17033731
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	17897319	http://www.ncbi.nlm.nih.gov/pubmed/17897319
PubMed	18449189	http://www.ncbi.nlm.nih.gov/pubmed/18449189
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19288050	http://www.ncbi.nlm.nih.gov/pubmed/19288050
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	19953639	http://www.ncbi.nlm.nih.gov/pubmed/19953639
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	21527911	http://www.ncbi.nlm.nih.gov/pubmed/21527911
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	26395888	http://www.ncbi.nlm.nih.gov/pubmed/26395888
PubMed	26477479	http://www.ncbi.nlm.nih.gov/pubmed/26477479
PubMed	8543009	http://www.ncbi.nlm.nih.gov/pubmed/8543009
PubMed	9565675	http://www.ncbi.nlm.nih.gov/pubmed/9565675
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_001107803	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001107803
RefSeq	NP_001278	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001278
SMART	SM00116	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00116
SMR	P51798	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P51798
STRING	9606.ENSP00000372193	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000372193&targetmode=cogs
SUPFAM	SSF81340	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81340
TCDB	2.A.49.3	http://www.tcdb.org/search/result.php?tc=2.A.49.3
UCSC	uc002clv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002clv&org=rat
UniGene	Hs.459649	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.459649
UniProtKB	CLCN7_HUMAN	http://www.uniprot.org/uniprot/CLCN7_HUMAN
UniProtKB-AC	P51798	http://www.uniprot.org/uniprot/P51798
charge	swissprot:CLCN7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CLCN7_HUMAN
eggNOG	COG0038	http://eggnogapi.embl.de/nog_data/html/tree/COG0038
eggNOG	KOG0474	http://eggnogapi.embl.de/nog_data/html/tree/KOG0474
epestfind	swissprot:CLCN7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CLCN7_HUMAN
garnier	swissprot:CLCN7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CLCN7_HUMAN
helixturnhelix	swissprot:CLCN7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLCN7_HUMAN
hmoment	swissprot:CLCN7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CLCN7_HUMAN
iep	swissprot:CLCN7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CLCN7_HUMAN
inforesidue	swissprot:CLCN7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CLCN7_HUMAN
neXtProt	NX_P51798	http://www.nextprot.org/db/entry/NX_P51798
octanol	swissprot:CLCN7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CLCN7_HUMAN
pepcoil	swissprot:CLCN7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CLCN7_HUMAN
pepdigest	swissprot:CLCN7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CLCN7_HUMAN
pepinfo	swissprot:CLCN7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CLCN7_HUMAN
pepnet	swissprot:CLCN7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CLCN7_HUMAN
pepstats	swissprot:CLCN7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CLCN7_HUMAN
pepwheel	swissprot:CLCN7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CLCN7_HUMAN
pepwindow	swissprot:CLCN7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CLCN7_HUMAN
sigcleave	swissprot:CLCN7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CLCN7_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ANO2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NQ90-1; Sequence=Displayed; Note=Splice site between exons 4 and 5 is non-canonical.; Name=2; IsoId=Q9NQ90-2; Sequence=VSP_040493, VSP_040494; Note=Splice site between exons 4 and 5 is non-canonical.; 
# AltName	ANO2_HUMAN	Transmembrane protein 16B
# CCDS	CCDS44807	-. [Q9NQ90-2]
# ChiTaRS	ANO2	human
# ENZYME REGULATION	Channel activity is repressed by chloride inhibitors; strongly by niflumic acid (NFA), partially by flufenamic acid (FFA), and only slightly by meclofenamic acid (MFA), 5-Nitro-2-(3-phenylpropylamino)benzoic acid (NPPB), 4- acetamido-4'-isothiocyanato-stilben-2,2'-disulfonate (SITS), and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS). {ECO	0000250}. 
# Ensembl	ENST00000327087	ENSP00000314048; ENSG00000047617. [Q9NQ90-2]
# Ensembl	ENST00000356134	ENSP00000348453; ENSG00000047617. [Q9NQ90-2]
# ExpressionAtlas	Q9NQ90	baseline and differential
# FUNCTION	ANO2_HUMAN	Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina. {ECO 0000269|PubMed 19474308, ECO 0000269|PubMed 20056604, ECO 0000269|PubMed 21890523, ECO 0000269|PubMed 21984732}. 
# GO_component	GO:0005654	nucleoplasm; IDA:HPA.
# GO_component	GO:0005886	plasma membrane; ISS:UniProtKB.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_function	GO:0005229	intracellular calcium activated chloride channel activity; IDA:UniProtKB.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9NQ90	HS
# HGNC	HGNC:1183	ANO2
# InterPro	IPR007632	Anoctamin
# InterPro	IPR031288	Anoctamin-2
# InterPro	IPR032394	Anoct_dimer
# MIM	610109	gene
# MISCELLANEOUS	ANO2_HUMAN	The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology. 
# Organism	ANO2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12308	PTHR12308; 2
# PANTHER	PTHR12308:SF20	PTHR12308:SF20; 2
# Pfam	PF04547	Anoctamin
# Pfam	PF16178	Anoct_dimer
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	ANO2_HUMAN	Anoctamin-2
# RefSeq	NP_001265525	NM_001278596.1. [Q9NQ90-1]
# RefSeq	NP_001265526	NM_001278597.1. [Q9NQ90-2]
# SEQUENCE CAUTION	Sequence=BAB14773.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the anoctamin family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	ANO2_HUMAN	Cell membrane {ECO 0000269|PubMed 20056604}; Multi-pass membrane protein {ECO 0000269|PubMed 20056604}. 
# SUBUNIT	Component of a presynaptic protein complex recruited to specialized plasma membrane domains of photoreceptors. Interacts with DLG4 by its C-terminal region (By similarity). {ECO	0000250}. 
# TCDB	1.A.17.1	the calcium-dependent chloride channel (ca-clc) family
# TISSUE SPECIFICITY	Retina, especially in the photoreceptor synaptic terminals. {ECO:0000269|PubMed	19474308}. 
# UCSC	uc058kbk	human. [Q9NQ90-1]
# eggNOG	ENOG410XS4S	LUCA
# eggNOG	KOG2514	Eukaryota
BLAST	swissprot:ANO2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ANO2_HUMAN
BioCyc	ZFISH:ENSG00000047617-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000047617-MONOMER
COXPRESdb	57101	http://coxpresdb.jp/data/gene/57101.shtml
CleanEx	HS_ANO2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ANO2
DOI	10.1007/s00424-011-0975-9	http://dx.doi.org/10.1007/s00424-011-0975-9
DOI	10.1038/aps.2011.48	http://dx.doi.org/10.1038/aps.2011.48
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M109.065367	http://dx.doi.org/10.1074/jbc.M109.065367
DOI	10.1113/expphysiol.2011.058198	http://dx.doi.org/10.1113/expphysiol.2011.058198
DOI	10.1113/expphysiol.2011.058214	http://dx.doi.org/10.1113/expphysiol.2011.058214
DOI	10.1113/expphysiol.2011.058230	http://dx.doi.org/10.1113/expphysiol.2011.058230
DOI	10.1523/JNEUROSCI.5546-08.2009	http://dx.doi.org/10.1523/JNEUROSCI.5546-08.2009
EMBL	AC006431	http://www.ebi.ac.uk/ena/data/view/AC006431
EMBL	AC006560	http://www.ebi.ac.uk/ena/data/view/AC006560
EMBL	AC137627	http://www.ebi.ac.uk/ena/data/view/AC137627
EMBL	AJ272204	http://www.ebi.ac.uk/ena/data/view/AJ272204
EMBL	AK024010	http://www.ebi.ac.uk/ena/data/view/AK024010
EMBL	FJ384095	http://www.ebi.ac.uk/ena/data/view/FJ384095
Ensembl	ENST00000327087	http://www.ensembl.org/id/ENST00000327087
Ensembl	ENST00000356134	http://www.ensembl.org/id/ENST00000356134
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_function	GO:0005229	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005229
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ANO2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ANO2
GeneID	57101	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57101
GeneTree	ENSGT00760000119015	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119015
HGNC	HGNC:1183	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1183
HOGENOM	HOG000006509	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006509&db=HOGENOM6
HOVERGEN	HBG069519	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG069519&db=HOVERGEN
HPA	HPA036276	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA036276
InParanoid	Q9NQ90	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NQ90
InterPro	IPR007632	http://www.ebi.ac.uk/interpro/entry/IPR007632
InterPro	IPR031288	http://www.ebi.ac.uk/interpro/entry/IPR031288
InterPro	IPR032394	http://www.ebi.ac.uk/interpro/entry/IPR032394
Jabion	57101	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=57101
KEGG_Gene	hsa:57101	http://www.genome.jp/dbget-bin/www_bget?hsa:57101
MIM	610109	http://www.ncbi.nlm.nih.gov/omim/610109
PANTHER	PTHR12308	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12308
PANTHER	PTHR12308:SF20	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12308:SF20
PSORT	swissprot:ANO2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ANO2_HUMAN
PSORT-B	swissprot:ANO2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ANO2_HUMAN
PSORT2	swissprot:ANO2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ANO2_HUMAN
Pfam	PF04547	http://pfam.xfam.org/family/PF04547
Pfam	PF16178	http://pfam.xfam.org/family/PF16178
PharmGKB	PA25504	http://www.pharmgkb.org/do/serve?objId=PA25504&objCls=Gene
Phobius	swissprot:ANO2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ANO2_HUMAN
PhylomeDB	Q9NQ90	http://phylomedb.org/?seqid=Q9NQ90
ProteinModelPortal	Q9NQ90	http://www.proteinmodelportal.org/query/uniprot/Q9NQ90
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	19474308	http://www.ncbi.nlm.nih.gov/pubmed/19474308
PubMed	20056604	http://www.ncbi.nlm.nih.gov/pubmed/20056604
PubMed	21607626	http://www.ncbi.nlm.nih.gov/pubmed/21607626
PubMed	21642943	http://www.ncbi.nlm.nih.gov/pubmed/21642943
PubMed	21890523	http://www.ncbi.nlm.nih.gov/pubmed/21890523
PubMed	21984732	http://www.ncbi.nlm.nih.gov/pubmed/21984732
PubMed	22302790	http://www.ncbi.nlm.nih.gov/pubmed/22302790
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_001265525	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001265525
RefSeq	NP_001265526	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001265526
STRING	9606.ENSP00000314048	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000314048&targetmode=cogs
TCDB	1.A.17.1	http://www.tcdb.org/search/result.php?tc=1.A.17.1
UCSC	uc058kbk	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc058kbk&org=rat
UniGene	Hs.148970	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.148970
UniProtKB	ANO2_HUMAN	http://www.uniprot.org/uniprot/ANO2_HUMAN
UniProtKB-AC	Q9NQ90	http://www.uniprot.org/uniprot/Q9NQ90
charge	swissprot:ANO2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ANO2_HUMAN
eggNOG	ENOG410XS4S	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS4S
eggNOG	KOG2514	http://eggnogapi.embl.de/nog_data/html/tree/KOG2514
epestfind	swissprot:ANO2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ANO2_HUMAN
garnier	swissprot:ANO2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ANO2_HUMAN
helixturnhelix	swissprot:ANO2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ANO2_HUMAN
hmoment	swissprot:ANO2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ANO2_HUMAN
iep	swissprot:ANO2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ANO2_HUMAN
inforesidue	swissprot:ANO2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ANO2_HUMAN
neXtProt	NX_Q9NQ90	http://www.nextprot.org/db/entry/NX_Q9NQ90
octanol	swissprot:ANO2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ANO2_HUMAN
pepcoil	swissprot:ANO2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ANO2_HUMAN
pepdigest	swissprot:ANO2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ANO2_HUMAN
pepinfo	swissprot:ANO2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ANO2_HUMAN
pepnet	swissprot:ANO2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ANO2_HUMAN
pepstats	swissprot:ANO2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ANO2_HUMAN
pepwheel	swissprot:ANO2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ANO2_HUMAN
pepwindow	swissprot:ANO2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ANO2_HUMAN
sigcleave	swissprot:ANO2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ANO2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SV2A_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7L0J3-1; Sequence=Displayed; Name=2; IsoId=Q7L0J3-2; Sequence=VSP_019265; Note=No experimental confirmation available.; 
# BioGrid	115229	6
# CCDS	CCDS940	-. [Q7L0J3-1]
# CDD	cd06174	MFS; 2
# ChiTaRS	SV2A	human
# DrugBank	DB01202	Levetiracetam
# Ensembl	ENST00000369145	ENSP00000358141; ENSG00000159164. [Q7L0J3-2]
# Ensembl	ENST00000369146	ENSP00000358142; ENSG00000159164. [Q7L0J3-1]
# FUNCTION	SV2A_HUMAN	Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity). {ECO 0000250}. 
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0005783	endoplasmic reticulum; IDA:LIFEdb.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005911	cell-cell junction; IEA:Ensembl.
# GO_component	GO:0008021	synaptic vesicle; TAS:ParkinsonsUK-UCL.
# GO_component	GO:0016021	integral component of membrane; IBA:GO_Central.
# GO_component	GO:0030672	synaptic vesicle membrane; IBA:GO_Central.
# GO_component	GO:0031594	neuromuscular junction; IEA:Ensembl.
# GO_component	GO:0043005	neuron projection; IBA:GO_Central.
# GO_component	GO:0043195	terminal bouton; IEA:Ensembl.
# GO_component	GO:0048786	presynaptic active zone; IEA:Ensembl.
# GO_function	GO:0004872	receptor activity; IEA:Ensembl.
# GO_function	GO:0019901	protein kinase binding; ISS:ParkinsonsUK-UCL.
# GO_function	GO:0022857	transmembrane transporter activity; IEA:InterPro.
# GO_process	GO:0001504	neurotransmitter uptake; IBA:GO_Central.
# GO_process	GO:0006874	cellular calcium ion homeostasis; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0042592	homeostatic process
# Genevisible	Q7L0J3	HS
# HGNC	HGNC:20566	SV2A
# IntAct	Q7L0J3	3
# InterPro	IPR001646	5peptide_repeat
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR005829	Sugar_transporter_CS
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# InterPro	IPR022308	SV2
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko04512	ECM-receptor interaction
# MIM	185860	gene
# MISCELLANEOUS	SV2A_HUMAN	Identified as the brain binding-site for the antiepileptic drug levetiracetam/lev. 
# Organism	SV2A_HUMAN	Homo sapiens (Human)
# PDB	4V11	X-ray; 1.95 A; B=81-90
# PROSITE	PS50850	MFS
# PTM	SV2A_HUMAN	N-glycosylated. {ECO 0000250}. 
# PTM	SV2A_HUMAN	Phosphorylation by CK1 of the N-terminal cytoplasmic domain regulates interaction with SYT1. {ECO 0000250}. 
# Pfam	PF00083	Sugar_tr
# Pfam	PF07690	MFS_1
# Pfam	PF13599	Pentapeptide_4
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-5250955	Toxicity of botulinum toxin type D (BoNT/D)
# Reactome	R-HSA-5250968	Toxicity of botulinum toxin type A (BoNT/A)
# Reactome	R-HSA-5250981	Toxicity of botulinum toxin type F (BoNT/F)
# Reactome	R-HSA-5250992	Toxicity of botulinum toxin type E (BoNT/E)
# RecName	SV2A_HUMAN	Synaptic vesicle glycoprotein 2A
# RefSeq	NP_001265648	NM_001278719.1
# RefSeq	NP_001315603	NM_001328674.1. [Q7L0J3-1]
# RefSeq	NP_001315604	NM_001328675.1. [Q7L0J3-1]
# RefSeq	NP_055664	NM_014849.4. [Q7L0J3-1]
# SEQUENCE CAUTION	Sequence=BAA34456.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI12573.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the major facilitator superfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	SV2A_HUMAN	Cell junction, synapse {ECO 0000250|UniProtKB Q9JIS5}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO 0000250|UniProtKB Q02563}; Multi-pass membrane protein {ECO 0000250|UniProtKB Q02563}. Note=Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic- like microvesicles in insulin-secreting cells of the pancreas (By similarity). Colocalizes with ATP2B1 at photoreceptor synaptic terminals. {ECO 0000250|UniProtKB Q02563, ECO 0000250|UniProtKB Q9JIS5}. 
# SUBUNIT	Interacts with SYT1/synaptotagmin-1 in a calcium- dependent manner. Binds the adapter protein complex AP-2 (By similarity). {ECO	0000250}. 
# SUPFAM	SSF103473	SSF103473; 3
# TIGRFAMs	TIGR01299	synapt_SV2
# UCSC	uc001etg	human. [Q7L0J3-1]
# eggNOG	ENOG410IRID	Eukaryota
# eggNOG	ENOG410YQME	LUCA
BLAST	swissprot:SV2A_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SV2A_HUMAN
COXPRESdb	9900	http://coxpresdb.jp/data/gene/9900.shtml
CleanEx	HS_SV2A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SV2A
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1073/pnas.0308208101	http://dx.doi.org/10.1073/pnas.0308208101
DOI	10.1093/dnares/12.2.117	http://dx.doi.org/10.1093/dnares/12.2.117
DOI	10.1093/dnares/5.5.277	http://dx.doi.org/10.1093/dnares/5.5.277
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DrugBank	DB01202	http://www.drugbank.ca/drugs/DB01202
EMBL	AB018279	http://www.ebi.ac.uk/ena/data/view/AB018279
EMBL	AK075480	http://www.ebi.ac.uk/ena/data/view/AK075480
EMBL	AL591493	http://www.ebi.ac.uk/ena/data/view/AL591493
EMBL	AL591493	http://www.ebi.ac.uk/ena/data/view/AL591493
EMBL	BC000776	http://www.ebi.ac.uk/ena/data/view/BC000776
EMBL	BC045111	http://www.ebi.ac.uk/ena/data/view/BC045111
EMBL	BX537754	http://www.ebi.ac.uk/ena/data/view/BX537754
EMBL	CH471121	http://www.ebi.ac.uk/ena/data/view/CH471121
EMBL	CH471121	http://www.ebi.ac.uk/ena/data/view/CH471121
Ensembl	ENST00000369145	http://www.ensembl.org/id/ENST00000369145
Ensembl	ENST00000369146	http://www.ensembl.org/id/ENST00000369146
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005911	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005911
GO_component	GO:0008021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008021
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030672	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030672
GO_component	GO:0031594	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031594
GO_component	GO:0043005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043005
GO_component	GO:0043195	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043195
GO_component	GO:0048786	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048786
GO_function	GO:0004872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004872
GO_function	GO:0019901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019901
GO_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GO_process	GO:0001504	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001504
GO_process	GO:0006874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GeneCards	SV2A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SV2A
GeneID	9900	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9900
GeneTree	ENSGT00550000074384	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074384
HGNC	HGNC:20566	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20566
HOVERGEN	HBG053967	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053967&db=HOVERGEN
HPA	CAB002226	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB002226
HPA	HPA007863	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA007863
InParanoid	Q7L0J3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q7L0J3
IntAct	Q7L0J3	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q7L0J3*
InterPro	IPR001646	http://www.ebi.ac.uk/interpro/entry/IPR001646
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR005829	http://www.ebi.ac.uk/interpro/entry/IPR005829
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
InterPro	IPR022308	http://www.ebi.ac.uk/interpro/entry/IPR022308
Jabion	9900	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9900
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:9900	http://www.genome.jp/dbget-bin/www_bget?hsa:9900
KEGG_Orthology	KO:K06258	http://www.genome.jp/dbget-bin/www_bget?KO:K06258
KEGG_Pathway	ko04512	http://www.genome.jp/kegg-bin/show_pathway?ko04512
MIM	185860	http://www.ncbi.nlm.nih.gov/omim/185860
MINT	MINT-4722799	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4722799
OMA	MSCISCF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MSCISCF
OrthoDB	EOG091G02NC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02NC
PDB	4V11	http://www.ebi.ac.uk/pdbe-srv/view/entry/4V11
PDBsum	4V11	http://www.ebi.ac.uk/pdbsum/4V11
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:SV2A_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SV2A_HUMAN
PSORT-B	swissprot:SV2A_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SV2A_HUMAN
PSORT2	swissprot:SV2A_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SV2A_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
Pfam	PF13599	http://pfam.xfam.org/family/PF13599
PharmGKB	PA128394564	http://www.pharmgkb.org/do/serve?objId=PA128394564&objCls=Gene
Phobius	swissprot:SV2A_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SV2A_HUMAN
PhylomeDB	Q7L0J3	http://phylomedb.org/?seqid=Q7L0J3
ProteinModelPortal	Q7L0J3	http://www.proteinmodelportal.org/query/uniprot/Q7L0J3
PubMed	15210974	http://www.ncbi.nlm.nih.gov/pubmed/15210974
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16303743	http://www.ncbi.nlm.nih.gov/pubmed/16303743
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	9872452	http://www.ncbi.nlm.nih.gov/pubmed/9872452
Reactome	R-HSA-5250955	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5250955
Reactome	R-HSA-5250968	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5250968
Reactome	R-HSA-5250981	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5250981
Reactome	R-HSA-5250992	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5250992
RefSeq	NP_001265648	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001265648
RefSeq	NP_001315603	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001315603
RefSeq	NP_001315604	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001315604
RefSeq	NP_055664	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055664
SMR	Q7L0J3	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q7L0J3
STRING	9606.ENSP00000358142	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000358142&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TIGRFAMs	TIGR01299	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01299
UCSC	uc001etg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001etg&org=rat
UniGene	Hs.516153	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.516153
UniProtKB	SV2A_HUMAN	http://www.uniprot.org/uniprot/SV2A_HUMAN
UniProtKB-AC	Q7L0J3	http://www.uniprot.org/uniprot/Q7L0J3
charge	swissprot:SV2A_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SV2A_HUMAN
eggNOG	ENOG410IRID	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IRID
eggNOG	ENOG410YQME	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YQME
epestfind	swissprot:SV2A_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SV2A_HUMAN
garnier	swissprot:SV2A_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SV2A_HUMAN
helixturnhelix	swissprot:SV2A_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SV2A_HUMAN
hmoment	swissprot:SV2A_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SV2A_HUMAN
iep	swissprot:SV2A_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SV2A_HUMAN
inforesidue	swissprot:SV2A_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SV2A_HUMAN
neXtProt	NX_Q7L0J3	http://www.nextprot.org/db/entry/NX_Q7L0J3
octanol	swissprot:SV2A_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SV2A_HUMAN
pepcoil	swissprot:SV2A_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SV2A_HUMAN
pepdigest	swissprot:SV2A_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SV2A_HUMAN
pepinfo	swissprot:SV2A_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SV2A_HUMAN
pepnet	swissprot:SV2A_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SV2A_HUMAN
pepstats	swissprot:SV2A_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SV2A_HUMAN
pepwheel	swissprot:SV2A_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SV2A_HUMAN
pepwindow	swissprot:SV2A_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SV2A_HUMAN
sigcleave	swissprot:SV2A_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SV2A_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CTNS_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O60931-1; Sequence=Displayed; Name=2; Synonyms=cystinosin-LKG; IsoId=O60931-2; Sequence=VSP_038377; 
# CCDS	CCDS11031	-. [O60931-1]
# CCDS	CCDS32530	-. [O60931-2]
# ChiTaRS	CTNS	human
# DISEASE	CTNS_HUMAN	Cystinosis, adult, non-nephropathic type (CTNSANN) [MIM 219750]  A form of cystinosis, a lysosomal storage disease due to defective transport of cystine across the lysosomal membrane. This results in cystine accumulation and crystallization in the cells causing widespread tissue damage. Cystinosis adult non-nephropathic type is characterized by ocular features and a benign course. Patients manifest mild photophobia due to conjunctival and corneal cystine crystals. {ECO 0000269|PubMed 10625078}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CTNS_HUMAN	Cystinosis, late-onset juvenile or adolescent nephropathic type (CTNSJAN) [MIM 219900]  A form of cystinosis, a lysosomal storage disease due to defective transport of cystine across the lysosomal membrane. This results in cystine accumulation and crystallization in the cells causing widespread tissue damage. Late-onset juvenile or adolescent nephropathic cystinosis is an intermediated form, manifesting first at age 10 to 12 years with proteinuria due to glomerular damage rather than with the manifestations of tubular damage that occur first in infantile cystinosis. There is no excess amino aciduria and stature is normal. Photophobia, late development of pigmentary retinopathy, and chronic headaches are features. {ECO 0000269|PubMed 10444339, ECO 0000269|PubMed 12442267, ECO 0000269|PubMed 9792862}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CTNS_HUMAN	Cystinosis, nephropathic type (CTNS) [MIM 219800]  A form of cystinosis, a lysosomal storage disease due to defective transport of cystine across the lysosomal membrane. This results in cystine accumulation and crystallization in the cells causing widespread tissue damage. The classical nephropathic form has onset in the first year of life and is characterized by a polyuro- polydipsic syndrome, marked height-weight growth delay, generalized impaired proximal tubular reabsorptive capacity, with severe fluid-electrolyte balance alterations, renal failure, ocular symptoms and other systemic complications. {ECO 0000269|PubMed 10482956, ECO 0000269|PubMed 10556299, ECO 0000269|PubMed 12204010, ECO 0000269|PubMed 12442267, ECO 0000269|PubMed 12825071, ECO 0000269|PubMed 19852576, ECO 0000269|PubMed 21786142, ECO 0000269|PubMed 22450360, ECO 0000269|PubMed 9792862}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00138	L-Cystine
# Ensembl	ENST00000046640	ENSP00000046640; ENSG00000040531. [O60931-1]
# Ensembl	ENST00000381870	ENSP00000371294; ENSG00000040531. [O60931-2]
# ExpressionAtlas	O60931	baseline and differential
# FUNCTION	CTNS_HUMAN	Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR. {ECO 0000269|PubMed 22649030}. 
# GO_component	GO:0005764	lysosome; IDA:MGI.
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005770	late endosome; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:MGI.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0042470	melanosome; IEA:UniProtKB-SubCell.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_component	GO:0045111	intermediate filament cytoskeleton; IDA:HPA.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0015184	L-cystine transmembrane transporter activity; IMP:UniProtKB.
# GO_process	GO:0002088	lens development in camera-type eye; IEA:Ensembl.
# GO_process	GO:0006520	cellular amino acid metabolic process; NAS:UniProtKB.
# GO_process	GO:0006749	glutathione metabolic process; IMP:UniProtKB.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0007420	brain development; IMP:UniProtKB.
# GO_process	GO:0007616	long-term memory; IEA:Ensembl.
# GO_process	GO:0007625	grooming behavior; IEA:Ensembl.
# GO_process	GO:0007628	adult walking behavior; IEA:Ensembl.
# GO_process	GO:0008542	visual learning; IEA:Ensembl.
# GO_process	GO:0015811	L-cystine transport; IDA:MGI.
# GO_process	GO:0042438	melanin biosynthetic process; IEA:UniProtKB-KW.
# GO_process	GO:0046034	ATP metabolic process; IMP:UniProtKB.
# GO_process	GO:0050890	cognition; IMP:UniProtKB.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005764	lysosome
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005856	cytoskeleton
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006520	cellular amino acid metabolic process
# GOslim_process	GO:0006790	sulfur compound metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0019748	secondary metabolic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	O60931	HS
# HGNC	HGNC:2518	CTNS
# InterPro	IPR005282	LC_transporter
# InterPro	IPR006603	PQ-loop_rpt
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Disease	H00275	[Inherited metabolic disease; Lysosomal storage disease] Cystinosis
# KEGG_Pathway	ko04142	Lysosome
# MIM	219750	phenotype
# MIM	219800	phenotype
# MIM	219900	phenotype
# MIM	606272	gene
# Organism	CTNS_HUMAN	Homo sapiens (Human)
# Orphanet	213	Cystinosis
# PANTHER	PTHR13131	PTHR13131
# Pfam	PF04193	PQ-loop; 2
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-425393	Transport of inorganic cations/anions and amino acids/oligopeptides
# Reactome	R-HSA-5223345	Miscellaneous transport and binding events
# RecName	CTNS_HUMAN	Cystinosin
# RefSeq	NP_001026851	NM_001031681.2. [O60931-2]
# RefSeq	NP_004928	NM_004937.2. [O60931-1]
# SIMILARITY	Belongs to the cystinosin family. {ECO	0000305}. 
# SIMILARITY	Contains 2 PQ-loop domains. {ECO	0000305}.
# SMART	SM00679	CTNS; 2
# SUBCELLULAR LOCATION	CTNS_HUMAN	Isoform 1  Lysosome membrane {ECO 0000269|PubMed 17897319}; Multi-pass membrane protein {ECO 0000269|PubMed 17897319}. Melanosome {ECO 0000269|PubMed 22649030}. 
# SUBCELLULAR LOCATION	CTNS_HUMAN	Isoform 2  Lysosome membrane {ECO 0000269|PubMed 18337546}; Multi-pass membrane protein. Cell membrane {ECO 0000269|PubMed 18337546}; Multi-pass membrane protein. 
# TCDB	2.A.43.1	the lysosomal cystine transporter (lct) family
# TIGRFAMs	TIGR00951	2A43
# TISSUE SPECIFICITY	Strongly expressed in pancreas, kidney (adult and fetal), skeletal muscle, melanocytes and keratinocytes. Expressed at lower levels in placenta and heart. Weakly expressed in lung, liver and brain (adult and fetal). Isoform 2 represents 5-20 % of CTNS transcripts, with the exception of the testis that expresses both isoforms in equal proportions. {ECO:0000269|PubMed	22649030}. 
# UCSC	uc002fwa	human. [O60931-1]
# eggNOG	ENOG410XQSD	LUCA
# eggNOG	KOG3145	Eukaryota
BLAST	swissprot:CTNS_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CTNS_HUMAN
BioCyc	ZFISH:ENSG00000040531-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000040531-MONOMER
COXPRESdb	1497	http://coxpresdb.jp/data/gene/1497.shtml
CleanEx	HS_CTNS	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CTNS
DOI	10.1002/(SICI)1098-1004(199912)14:6<454::AID-HUMU2>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(199912)14:6<454::AID-HUMU2>3.0.CO
DOI	10.1002/humu.10141	http://dx.doi.org/10.1002/humu.10141
DOI	10.1002/humu.9063	http://dx.doi.org/10.1002/humu.9063
DOI	10.1006/mgme.1998.2790	http://dx.doi.org/10.1006/mgme.1998.2790
DOI	10.1006/mgme.1999.2876	http://dx.doi.org/10.1006/mgme.1999.2876
DOI	10.1007/s00418-012-0958-8	http://dx.doi.org/10.1007/s00418-012-0958-8
DOI	10.1007/s00467-011-1942-6	http://dx.doi.org/10.1007/s00467-011-1942-6
DOI	10.1016/j.gene.2012.03.047	http://dx.doi.org/10.1016/j.gene.2012.03.047
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1038/ng0498-319	http://dx.doi.org/10.1038/ng0498-319
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.ejhg.5200349	http://dx.doi.org/10.1038/sj.ejhg.5200349
DOI	10.1038/sj.ejhg.5200993	http://dx.doi.org/10.1038/sj.ejhg.5200993
DOI	10.1086/302118	http://dx.doi.org/10.1086/302118
DOI	10.1093/hmg/8.13.2507	http://dx.doi.org/10.1093/hmg/8.13.2507
DOI	10.1096/fj.11-201376	http://dx.doi.org/10.1096/fj.11-201376
DOI	10.1101/gr.10.2.165	http://dx.doi.org/10.1101/gr.10.2.165
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1600-0854.2007.00643.x	http://dx.doi.org/10.1111/j.1600-0854.2007.00643.x
DOI	10.1152/ajprenal.00413.2007	http://dx.doi.org/10.1152/ajprenal.00413.2007
DOI	10.1203/00006450-200001000-00007	http://dx.doi.org/10.1203/00006450-200001000-00007
DOI	10.3109/13816810903200953	http://dx.doi.org/10.3109/13816810903200953
DrugBank	DB00138	http://www.drugbank.ca/drugs/DB00138
EMBL	AC027796	http://www.ebi.ac.uk/ena/data/view/AC027796
EMBL	AC132942	http://www.ebi.ac.uk/ena/data/view/AC132942
EMBL	AF168787	http://www.ebi.ac.uk/ena/data/view/AF168787
EMBL	AH008011	http://www.ebi.ac.uk/ena/data/view/AH008011
EMBL	AJ222967	http://www.ebi.ac.uk/ena/data/view/AJ222967
EMBL	AK292019	http://www.ebi.ac.uk/ena/data/view/AK292019
EMBL	BC032850	http://www.ebi.ac.uk/ena/data/view/BC032850
EMBL	CH471108	http://www.ebi.ac.uk/ena/data/view/CH471108
EMBL	CH471108	http://www.ebi.ac.uk/ena/data/view/CH471108
EMBL	CH471108	http://www.ebi.ac.uk/ena/data/view/CH471108
EMBL	Y15924	http://www.ebi.ac.uk/ena/data/view/Y15924
EMBL	Y15925	http://www.ebi.ac.uk/ena/data/view/Y15925
EMBL	Y15926	http://www.ebi.ac.uk/ena/data/view/Y15926
EMBL	Y15927	http://www.ebi.ac.uk/ena/data/view/Y15927
EMBL	Y15928	http://www.ebi.ac.uk/ena/data/view/Y15928
EMBL	Y15929	http://www.ebi.ac.uk/ena/data/view/Y15929
EMBL	Y15930	http://www.ebi.ac.uk/ena/data/view/Y15930
EMBL	Y15931	http://www.ebi.ac.uk/ena/data/view/Y15931
EMBL	Y15932	http://www.ebi.ac.uk/ena/data/view/Y15932
EMBL	Y15933	http://www.ebi.ac.uk/ena/data/view/Y15933
Ensembl	ENST00000046640	http://www.ensembl.org/id/ENST00000046640
Ensembl	ENST00000381870	http://www.ensembl.org/id/ENST00000381870
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005770	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005770
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0042470	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042470
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_component	GO:0045111	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045111
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0015184	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015184
GO_process	GO:0002088	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002088
GO_process	GO:0006520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520
GO_process	GO:0006749	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006749
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0007420	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007420
GO_process	GO:0007616	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007616
GO_process	GO:0007625	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007625
GO_process	GO:0007628	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007628
GO_process	GO:0008542	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008542
GO_process	GO:0015811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015811
GO_process	GO:0042438	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042438
GO_process	GO:0046034	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046034
GO_process	GO:0050890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050890
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520
GOslim_process	GO:0006790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0019748	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019748
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	CTNS	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CTNS
GeneID	1497	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1497
GeneTree	ENSGT00390000005338	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000005338
HGNC	HGNC:2518	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2518
HOGENOM	HOG000192503	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000192503&db=HOGENOM6
HOVERGEN	HBG003083	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003083&db=HOVERGEN
HPA	HPA046947	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA046947
InParanoid	O60931	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O60931
InterPro	IPR005282	http://www.ebi.ac.uk/interpro/entry/IPR005282
InterPro	IPR006603	http://www.ebi.ac.uk/interpro/entry/IPR006603
Jabion	1497	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1497
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Disease	H00275	http://www.genome.jp/dbget-bin/www_bget?H00275
KEGG_Gene	hsa:1497	http://www.genome.jp/dbget-bin/www_bget?hsa:1497
KEGG_Orthology	KO:K12386	http://www.genome.jp/dbget-bin/www_bget?KO:K12386
KEGG_Pathway	ko04142	http://www.genome.jp/kegg-bin/show_pathway?ko04142
MIM	219750	http://www.ncbi.nlm.nih.gov/omim/219750
MIM	219800	http://www.ncbi.nlm.nih.gov/omim/219800
MIM	219900	http://www.ncbi.nlm.nih.gov/omim/219900
MIM	606272	http://www.ncbi.nlm.nih.gov/omim/606272
OMA	FFIQHFC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FFIQHFC
Orphanet	213	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=213
OrthoDB	EOG091G0BG6	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0BG6
PANTHER	PTHR13131	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13131
PSORT	swissprot:CTNS_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CTNS_HUMAN
PSORT-B	swissprot:CTNS_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CTNS_HUMAN
PSORT2	swissprot:CTNS_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CTNS_HUMAN
Pfam	PF04193	http://pfam.xfam.org/family/PF04193
PharmGKB	PA27019	http://www.pharmgkb.org/do/serve?objId=PA27019&objCls=Gene
Phobius	swissprot:CTNS_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CTNS_HUMAN
PhylomeDB	O60931	http://phylomedb.org/?seqid=O60931
ProteinModelPortal	O60931	http://www.proteinmodelportal.org/query/uniprot/O60931
PubMed	10068513	http://www.ncbi.nlm.nih.gov/pubmed/10068513
PubMed	10444339	http://www.ncbi.nlm.nih.gov/pubmed/10444339
PubMed	10482956	http://www.ncbi.nlm.nih.gov/pubmed/10482956
PubMed	10556299	http://www.ncbi.nlm.nih.gov/pubmed/10556299
PubMed	10571941	http://www.ncbi.nlm.nih.gov/pubmed/10571941
PubMed	10625078	http://www.ncbi.nlm.nih.gov/pubmed/10625078
PubMed	10673275	http://www.ncbi.nlm.nih.gov/pubmed/10673275
PubMed	12204010	http://www.ncbi.nlm.nih.gov/pubmed/12204010
PubMed	12442267	http://www.ncbi.nlm.nih.gov/pubmed/12442267
PubMed	12825071	http://www.ncbi.nlm.nih.gov/pubmed/12825071
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	17897319	http://www.ncbi.nlm.nih.gov/pubmed/17897319
PubMed	18337546	http://www.ncbi.nlm.nih.gov/pubmed/18337546
PubMed	19852576	http://www.ncbi.nlm.nih.gov/pubmed/19852576
PubMed	21786142	http://www.ncbi.nlm.nih.gov/pubmed/21786142
PubMed	22450360	http://www.ncbi.nlm.nih.gov/pubmed/22450360
PubMed	22544350	http://www.ncbi.nlm.nih.gov/pubmed/22544350
PubMed	22649030	http://www.ncbi.nlm.nih.gov/pubmed/22649030
PubMed	9537412	http://www.ncbi.nlm.nih.gov/pubmed/9537412
PubMed	9792862	http://www.ncbi.nlm.nih.gov/pubmed/9792862
Reactome	R-HSA-425393	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425393
Reactome	R-HSA-5223345	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5223345
RefSeq	NP_001026851	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001026851
RefSeq	NP_004928	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004928
SMART	SM00679	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00679
STRING	9606.ENSP00000371294	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000371294&targetmode=cogs
TCDB	2.A.43.1	http://www.tcdb.org/search/result.php?tc=2.A.43.1
TIGRFAMs	TIGR00951	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00951
UCSC	uc002fwa	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002fwa&org=rat
UniGene	Hs.187667	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.187667
UniProtKB	CTNS_HUMAN	http://www.uniprot.org/uniprot/CTNS_HUMAN
UniProtKB-AC	O60931	http://www.uniprot.org/uniprot/O60931
charge	swissprot:CTNS_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CTNS_HUMAN
eggNOG	ENOG410XQSD	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQSD
eggNOG	KOG3145	http://eggnogapi.embl.de/nog_data/html/tree/KOG3145
epestfind	swissprot:CTNS_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CTNS_HUMAN
garnier	swissprot:CTNS_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CTNS_HUMAN
helixturnhelix	swissprot:CTNS_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CTNS_HUMAN
hmoment	swissprot:CTNS_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CTNS_HUMAN
iep	swissprot:CTNS_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CTNS_HUMAN
inforesidue	swissprot:CTNS_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CTNS_HUMAN
neXtProt	NX_O60931	http://www.nextprot.org/db/entry/NX_O60931
octanol	swissprot:CTNS_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CTNS_HUMAN
pepcoil	swissprot:CTNS_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CTNS_HUMAN
pepdigest	swissprot:CTNS_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CTNS_HUMAN
pepinfo	swissprot:CTNS_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CTNS_HUMAN
pepnet	swissprot:CTNS_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CTNS_HUMAN
pepstats	swissprot:CTNS_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CTNS_HUMAN
pepwheel	swissprot:CTNS_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CTNS_HUMAN
pepwindow	swissprot:CTNS_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CTNS_HUMAN
sigcleave	swissprot:CTNS_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CTNS_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ABCA9_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8IUA7-1; Sequence=Displayed; Name=2; Synonyms=ABCA9delta+55; IsoId=Q8IUA7-2; Sequence=VSP_020705; Note=No experimental confirmation available.; Name=3; Synonyms=ABCA9delta+73; IsoId=Q8IUA7-3; Sequence=VSP_020707, VSP_020709; Note=No experimental confirmation available.; Name=4; Synonyms=ABCA9delta-95; IsoId=Q8IUA7-4; Sequence=VSP_020708, VSP_020709; Note=No experimental confirmation available.; Name=5; IsoId=Q8IUA7-5; Sequence=VSP_020706; Note=No experimental confirmation available.; 
# CCDS	CCDS11681	-. [Q8IUA7-1]
# DEVELOPMENTAL STAGE	Expressed in fetal tissues with higher expression in fetal heart and kidney. {ECO:0000269|PubMed	12150964}. 
# Ensembl	ENST00000340001	ENSP00000342216; ENSG00000154258. [Q8IUA7-1]
# Ensembl	ENST00000495634	ENSP00000465601; ENSG00000154258. [Q8IUA7-5]
# ExpressionAtlas	Q8IUA7	baseline and differential
# FUNCTION	ABCA9_HUMAN	May play a role in monocyte differentiation and lipid homeostasis. {ECO 0000269|PubMed 12150964}. 
# GO_component	GO:0005743	mitochondrial inner membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; IBA:GO_Central.
# GO_process	GO:0006869	lipid transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# Gene3D	3.40.50.300	-; 2.
# Genevisible	Q8IUA7	HS
# HGNC	HGNC:39	ABCA9
# INDUCTION	Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages. {ECO:0000269|PubMed	12150964}. 
# IntAct	Q8IUA7	2
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR026082	ABC_A
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko02010	ABC transporters
# MIM	612507	gene
# Organism	ABCA9_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR19229	PTHR19229
# PROSITE	PS50893	ABC_TRANSPORTER_2; 2
# Pfam	PF00005	ABC_tran; 2
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-1369062	ABC transporters in lipid homeostasis
# RecName	ABCA9_HUMAN	ATP-binding cassette sub-family A member 9
# RefSeq	NP_525022	NM_080283.3. [Q8IUA7-1]
# SEQUENCE CAUTION	Sequence=AAH62472.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC11021.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCA family. {ECO	0000305}. 
# SIMILARITY	Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA; 2
# SUBCELLULAR LOCATION	ABCA9_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF52540	SSF52540; 2
# TCDB	3.A.1.211.16	the atp-binding cassette (abc) superfamily
# TISSUE SPECIFICITY	Widely expressed with higher expression in heart. {ECO	0000269|Ref.1}. 
# UCSC	uc002jhu	human. [Q8IUA7-1]
# WEB RESOURCE	ABCA9_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=Q8IUA7";
# eggNOG	COG1131	LUCA
# eggNOG	KOG0059	Eukaryota
BLAST	swissprot:ABCA9_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCA9_HUMAN
COXPRESdb	10350	http://coxpresdb.jp/data/gene/10350.shtml
CleanEx	HS_ABCA9	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCA9
DOI	10.1016/S0006-291X(02)00659-9	http://dx.doi.org/10.1016/S0006-291X(02)00659-9
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF423307	http://www.ebi.ac.uk/ena/data/view/AF423307
EMBL	AF423308	http://www.ebi.ac.uk/ena/data/view/AF423308
EMBL	AF423309	http://www.ebi.ac.uk/ena/data/view/AF423309
EMBL	AF423310	http://www.ebi.ac.uk/ena/data/view/AF423310
EMBL	AF423311	http://www.ebi.ac.uk/ena/data/view/AF423311
EMBL	AF423312	http://www.ebi.ac.uk/ena/data/view/AF423312
EMBL	AF423313	http://www.ebi.ac.uk/ena/data/view/AF423313
EMBL	AF423314	http://www.ebi.ac.uk/ena/data/view/AF423314
EMBL	AF423315	http://www.ebi.ac.uk/ena/data/view/AF423315
EMBL	AF423316	http://www.ebi.ac.uk/ena/data/view/AF423316
EMBL	AF423317	http://www.ebi.ac.uk/ena/data/view/AF423317
EMBL	AF423318	http://www.ebi.ac.uk/ena/data/view/AF423318
EMBL	AF423320	http://www.ebi.ac.uk/ena/data/view/AF423320
EMBL	AF423321	http://www.ebi.ac.uk/ena/data/view/AF423321
EMBL	AF423322	http://www.ebi.ac.uk/ena/data/view/AF423322
EMBL	AF423323	http://www.ebi.ac.uk/ena/data/view/AF423323
EMBL	AF423324	http://www.ebi.ac.uk/ena/data/view/AF423324
EMBL	AF423325	http://www.ebi.ac.uk/ena/data/view/AF423325
EMBL	AF423326	http://www.ebi.ac.uk/ena/data/view/AF423326
EMBL	AF423327	http://www.ebi.ac.uk/ena/data/view/AF423327
EMBL	AF423328	http://www.ebi.ac.uk/ena/data/view/AF423328
EMBL	AF423329	http://www.ebi.ac.uk/ena/data/view/AF423329
EMBL	AF423330	http://www.ebi.ac.uk/ena/data/view/AF423330
EMBL	AF423331	http://www.ebi.ac.uk/ena/data/view/AF423331
EMBL	AF423332	http://www.ebi.ac.uk/ena/data/view/AF423332
EMBL	AF423333	http://www.ebi.ac.uk/ena/data/view/AF423333
EMBL	AF423334	http://www.ebi.ac.uk/ena/data/view/AF423334
EMBL	AF423335	http://www.ebi.ac.uk/ena/data/view/AF423335
EMBL	AF423336	http://www.ebi.ac.uk/ena/data/view/AF423336
EMBL	AF423337	http://www.ebi.ac.uk/ena/data/view/AF423337
EMBL	AF423338	http://www.ebi.ac.uk/ena/data/view/AF423338
EMBL	AF423339	http://www.ebi.ac.uk/ena/data/view/AF423339
EMBL	AF423340	http://www.ebi.ac.uk/ena/data/view/AF423340
EMBL	AF423341	http://www.ebi.ac.uk/ena/data/view/AF423341
EMBL	AF423342	http://www.ebi.ac.uk/ena/data/view/AF423342
EMBL	AF423343	http://www.ebi.ac.uk/ena/data/view/AF423343
EMBL	AF423344	http://www.ebi.ac.uk/ena/data/view/AF423344
EMBL	AF423345	http://www.ebi.ac.uk/ena/data/view/AF423345
EMBL	AF423346	http://www.ebi.ac.uk/ena/data/view/AF423346
EMBL	AK057068	http://www.ebi.ac.uk/ena/data/view/AK057068
EMBL	AK074491	http://www.ebi.ac.uk/ena/data/view/AK074491
EMBL	AY028899	http://www.ebi.ac.uk/ena/data/view/AY028899
EMBL	BC062472	http://www.ebi.ac.uk/ena/data/view/BC062472
Ensembl	ENST00000340001	http://www.ensembl.org/id/ENST00000340001
Ensembl	ENST00000495634	http://www.ensembl.org/id/ENST00000495634
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GO_process	GO:0006869	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006869
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCA9	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCA9
GeneID	10350	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10350
GeneTree	ENSGT00760000118965	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118965
H-InvDB	HIX0014120	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0014120
HGNC	HGNC:39	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:39
HOGENOM	HOG000231057	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231057&db=HOGENOM6
HOVERGEN	HBG079884	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG079884&db=HOVERGEN
HPA	HPA054823	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA054823
InParanoid	Q8IUA7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8IUA7
IntAct	Q8IUA7	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8IUA7*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR026082	http://www.ebi.ac.uk/interpro/entry/IPR026082
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	10350	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10350
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:10350	http://www.genome.jp/dbget-bin/www_bget?hsa:10350
KEGG_Orthology	KO:K05651	http://www.genome.jp/dbget-bin/www_bget?KO:K05651
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
MIM	612507	http://www.ncbi.nlm.nih.gov/omim/612507
OMA	CLEMKFR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CLEMKFR
OrthoDB	EOG091G00AG	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00AG
PANTHER	PTHR19229	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19229
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PSORT	swissprot:ABCA9_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCA9_HUMAN
PSORT-B	swissprot:ABCA9_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCA9_HUMAN
PSORT2	swissprot:ABCA9_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCA9_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
PharmGKB	PA24384	http://www.pharmgkb.org/do/serve?objId=PA24384&objCls=Gene
Phobius	swissprot:ABCA9_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCA9_HUMAN
PhylomeDB	Q8IUA7	http://phylomedb.org/?seqid=Q8IUA7
ProteinModelPortal	Q8IUA7	http://www.proteinmodelportal.org/query/uniprot/Q8IUA7
PubMed	12150964	http://www.ncbi.nlm.nih.gov/pubmed/12150964
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
Reactome	R-HSA-1369062	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1369062
RefSeq	NP_525022	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_525022
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	Q8IUA7	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8IUA7
STRING	9606.ENSP00000342216	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000342216&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TCDB	3.A.1.211.16	http://www.tcdb.org/search/result.php?tc=3.A.1.211.16
UCSC	uc002jhu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002jhu&org=rat
UniGene	Hs.131686	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.131686
UniProtKB	ABCA9_HUMAN	http://www.uniprot.org/uniprot/ABCA9_HUMAN
UniProtKB-AC	Q8IUA7	http://www.uniprot.org/uniprot/Q8IUA7
charge	swissprot:ABCA9_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCA9_HUMAN
eggNOG	COG1131	http://eggnogapi.embl.de/nog_data/html/tree/COG1131
eggNOG	KOG0059	http://eggnogapi.embl.de/nog_data/html/tree/KOG0059
epestfind	swissprot:ABCA9_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCA9_HUMAN
garnier	swissprot:ABCA9_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCA9_HUMAN
helixturnhelix	swissprot:ABCA9_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCA9_HUMAN
hmoment	swissprot:ABCA9_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCA9_HUMAN
iep	swissprot:ABCA9_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCA9_HUMAN
inforesidue	swissprot:ABCA9_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCA9_HUMAN
neXtProt	NX_Q8IUA7	http://www.nextprot.org/db/entry/NX_Q8IUA7
octanol	swissprot:ABCA9_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCA9_HUMAN
pepcoil	swissprot:ABCA9_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCA9_HUMAN
pepdigest	swissprot:ABCA9_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCA9_HUMAN
pepinfo	swissprot:ABCA9_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCA9_HUMAN
pepnet	swissprot:ABCA9_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCA9_HUMAN
pepstats	swissprot:ABCA9_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCA9_HUMAN
pepwheel	swissprot:ABCA9_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCA9_HUMAN
pepwindow	swissprot:ABCA9_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCA9_HUMAN
sigcleave	swissprot:ABCA9_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCA9_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	MDR1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P08183-1; Sequence=Displayed; Name=2; IsoId=P08183-2; Sequence=VSP_055769; 
# AltName	MDR1_HUMAN	ATP-binding cassette sub-family B member 1
# AltName	MDR1_HUMAN	CD243
# AltName	MDR1_HUMAN	P-glycoprotein 1
# BRENDA	3.6.3.44	2681
# BioGrid	111262	14
# CATALYTIC ACTIVITY	MDR1_HUMAN	ATP + H(2)O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out). 
# CCDS	CCDS5608	-. [P08183-1]
# ChiTaRS	ABCB1	human
# DISEASE	MDR1_HUMAN	Inflammatory bowel disease 13 (IBD13) [MIM 612244]  A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# DrugBank	DB00027	Gramicidin D
# DrugBank	DB00091	Cyclosporine
# DrugBank	DB00171	Adenosine triphosphate
# DrugBank	DB00175	Pravastatin
# DrugBank	DB00176	Fluvoxamine
# DrugBank	DB00196	Fluconazole
# DrugBank	DB00199	Erythromycin
# DrugBank	DB00201	Caffeine
# DrugBank	DB00206	Reserpine
# DrugBank	DB00207	Azithromycin
# DrugBank	DB00213	Pantoprazole
# DrugBank	DB00215	Citalopram
# DrugBank	DB00216	Eletriptan
# DrugBank	DB00220	Nelfinavir
# DrugBank	DB00224	Indinavir
# DrugBank	DB00227	Lovastatin
# DrugBank	DB00234	Reboxetine
# DrugBank	DB00252	Phenytoin
# DrugBank	DB00255	Diethylstilbestrol
# DrugBank	DB00257	Clotrimazole
# DrugBank	DB00264	Metoprolol
# DrugBank	DB00276	Amsacrine
# DrugBank	DB00279	Liothyronine
# DrugBank	DB00281	Lidocaine
# DrugBank	DB00285	Venlafaxine
# DrugBank	DB00286	Conjugated Estrogens
# DrugBank	DB00295	Morphine
# DrugBank	DB00305	Mitomycin
# DrugBank	DB00316	Acetaminophen
# DrugBank	DB00317	Gefitinib
# DrugBank	DB00320	Dihydroergotamine
# DrugBank	DB00321	Amitriptyline
# DrugBank	DB00328	Indomethacin
# DrugBank	DB00333	Methadone
# DrugBank	DB00334	Olanzapine
# DrugBank	DB00335	Atenolol
# DrugBank	DB00338	Omeprazole
# DrugBank	DB00343	Diltiazem
# DrugBank	DB00344	Protriptyline
# DrugBank	DB00345	Aminohippurate
# DrugBank	DB00349	Clobazam
# DrugBank	DB00351	Megestrol acetate
# DrugBank	DB00358	Mefloquine
# DrugBank	DB00361	Vinorelbine
# DrugBank	DB00363	Clozapine
# DrugBank	DB00371	Meprobamate
# DrugBank	DB00373	Timolol
# DrugBank	DB00381	Amlodipine
# DrugBank	DB00390	Digoxin
# DrugBank	DB00396	Progesterone
# DrugBank	DB00398	Sorafenib
# DrugBank	DB00401	Nisoldipine
# DrugBank	DB00421	Spironolactone
# DrugBank	DB00428	Streptozocin
# DrugBank	DB00440	Trimethoprim
# DrugBank	DB00441	Gemcitabine
# DrugBank	DB00443	Betamethasone
# DrugBank	DB00448	Lansoprazole
# DrugBank	DB00451	Levothyroxine
# DrugBank	DB00455	Loratadine
# DrugBank	DB00457	Prazosin
# DrugBank	DB00458	Imipramine
# DrugBank	DB00468	Quinine
# DrugBank	DB00470	Dronabinol
# DrugBank	DB00472	Fluoxetine
# DrugBank	DB00477	Chlorpromazine
# DrugBank	DB00480	Lenalidomide
# DrugBank	DB00490	Buspirone
# DrugBank	DB00495	Zidovudine
# DrugBank	DB00501	Cimetidine
# DrugBank	DB00502	Haloperidol
# DrugBank	DB00503	Ritonavir
# DrugBank	DB00508	Triflupromazine
# DrugBank	DB00514	Dextromethorphan
# DrugBank	DB00515	Cisplatin
# DrugBank	DB00518	Albendazole
# DrugBank	DB00520	Caspofungin
# DrugBank	DB00523	Alitretinoin
# DrugBank	DB00530	Erlotinib
# DrugBank	DB00531	Cyclophosphamide
# DrugBank	DB00537	Ciprofloxacin
# DrugBank	DB00539	Toremifene
# DrugBank	DB00541	Vincristine
# DrugBank	DB00555	Lamotrigine
# DrugBank	DB00563	Methotrexate
# DrugBank	DB00564	Carbamazepine
# DrugBank	DB00570	Vinblastine
# DrugBank	DB00571	Propranolol
# DrugBank	DB00575	Clonidine
# DrugBank	DB00584	Enalapril
# DrugBank	DB00585	Nizatidine
# DrugBank	DB00586	Diclofenac
# DrugBank	DB00590	Doxazosin
# DrugBank	DB00602	Ivermectin
# DrugBank	DB00608	Chloroquine
# DrugBank	DB00619	Imatinib
# DrugBank	DB00622	Nicardipine
# DrugBank	DB00623	Fluphenazine
# DrugBank	DB00624	Testosterone
# DrugBank	DB00635	Prednisone
# DrugBank	DB00637	Astemizole
# DrugBank	DB00641	Simvastatin
# DrugBank	DB00643	Mebendazole
# DrugBank	DB00655	Estrone
# DrugBank	DB00656	Trazodone
# DrugBank	DB00661	Verapamil
# DrugBank	DB00669	Sumatriptan
# DrugBank	DB00672	Chlorpropamide
# DrugBank	DB00675	Tamoxifen
# DrugBank	DB00678	Losartan
# DrugBank	DB00683	Midazolam
# DrugBank	DB00688	Mycophenolate mofetil
# DrugBank	DB00690	Flurazepam
# DrugBank	DB00694	Daunorubicin
# DrugBank	DB00696	Ergotamine
# DrugBank	DB00701	Amprenavir
# DrugBank	DB00704	Naltrexone
# DrugBank	DB00709	Lamivudine
# DrugBank	DB00715	Paroxetine
# DrugBank	DB00717	Norethisterone
# DrugBank	DB00722	Lisinopril
# DrugBank	DB00726	Trimipramine
# DrugBank	DB00734	Risperidone
# DrugBank	DB00741	Hydrocortisone
# DrugBank	DB00742	Mannitol
# DrugBank	DB00747	Scopolamine
# DrugBank	DB00751	Epinastine
# DrugBank	DB00758	Clopidogrel
# DrugBank	DB00762	Irinotecan
# DrugBank	DB00773	Etoposide
# DrugBank	DB00778	Roxithromycin
# DrugBank	DB00783	Estradiol
# DrugBank	DB00790	Perindopril
# DrugBank	DB00796	Candesartan
# DrugBank	DB00802	Alfentanil
# DrugBank	DB00810	Biperiden
# DrugBank	DB00813	Fentanyl
# DrugBank	DB00829	Diazepam
# DrugBank	DB00831	Trifluoperazine
# DrugBank	DB00834	Mifepristone
# DrugBank	DB00836	Loperamide
# DrugBank	DB00845	Clofazimine
# DrugBank	DB00860	Prednisolone
# DrugBank	DB00863	Ranitidine
# DrugBank	DB00864	Tacrolimus
# DrugBank	DB00875	Flupentixol
# DrugBank	DB00877	Sirolimus
# DrugBank	DB00882	Clomifene
# DrugBank	DB00908	Quinidine
# DrugBank	DB00915	Amantadine
# DrugBank	DB00921	Buprenorphine
# DrugBank	DB00934	Maprotiline
# DrugBank	DB00936	Salicylic acid
# DrugBank	DB00945	Acetylsalicylic acid
# DrugBank	DB00950	Fexofenadine
# DrugBank	DB00959	Methylprednisolone
# DrugBank	DB00966	Telmisartan
# DrugBank	DB00967	Desloratadine
# DrugBank	DB00970	Dactinomycin
# DrugBank	DB00972	Azelastine
# DrugBank	DB00973	Ezetimibe
# DrugBank	DB00975	Dipyridamole
# DrugBank	DB00977	Ethinyl Estradiol
# DrugBank	DB00997	Doxorubicin
# DrugBank	DB01016	Glyburide
# DrugBank	DB01023	Felodipine
# DrugBank	DB01026	Ketoconazole
# DrugBank	DB01030	Topotecan
# DrugBank	DB01032	Probenecid
# DrugBank	DB01037	Selegiline
# DrugBank	DB01045	Rifampicin
# DrugBank	DB01050	Ibuprofen
# DrugBank	DB01054	Nitrendipine
# DrugBank	DB01069	Promethazine
# DrugBank	DB01072	Atazanavir
# DrugBank	DB01076	Atorvastatin
# DrugBank	DB01086	Benzocaine
# DrugBank	DB01100	Pimozide
# DrugBank	DB01103	Quinacrine
# DrugBank	DB01104	Sertraline
# DrugBank	DB01110	Miconazole
# DrugBank	DB01115	Nifedipine
# DrugBank	DB01118	Amiodarone
# DrugBank	DB01136	Carvedilol
# DrugBank	DB01137	Levofloxacin
# DrugBank	DB01138	Sulfinpyrazone
# DrugBank	DB01142	Doxepin
# DrugBank	DB01149	Nefazodone
# DrugBank	DB01151	Desipramine
# DrugBank	DB01162	Terazosin
# DrugBank	DB01167	Itraconazole
# DrugBank	DB01169	Arsenic trioxide
# DrugBank	DB01174	Phenobarbital
# DrugBank	DB01182	Propafenone
# DrugBank	DB01183	Naloxone
# DrugBank	DB01184	Domperidone
# DrugBank	DB01193	Acebutolol
# DrugBank	DB01196	Estramustine
# DrugBank	DB01197	Captopril
# DrugBank	DB01200	Bromocriptine
# DrugBank	DB01202	Levetiracetam
# DrugBank	DB01203	Nadolol
# DrugBank	DB01204	Mitoxantrone
# DrugBank	DB01208	Sparfloxacin
# DrugBank	DB01211	Clarithromycin
# DrugBank	DB01221	Ketamine
# DrugBank	DB01224	Quetiapine
# DrugBank	DB01229	Paclitaxel
# DrugBank	DB01232	Saquinavir
# DrugBank	DB01234	Dexamethasone
# DrugBank	DB01239	Chlorprothixene
# DrugBank	DB01242	Clomipramine
# DrugBank	DB01244	Bepridil
# DrugBank	DB01248	Docetaxel
# DrugBank	DB01253	Ergonovine
# DrugBank	DB01254	Dasatinib
# DrugBank	DB01259	Lapatinib
# DrugBank	DB01261	Sitagliptin
# DrugBank	DB01263	Posaconazole
# DrugBank	DB01268	Sunitinib
# DrugBank	DB01339	Vecuronium
# DrugBank	DB01340	Cilazapril
# DrugBank	DB01361	Troleandomycin
# DrugBank	DB01394	Colchicine
# DrugBank	DB01396	Digitoxin
# DrugBank	DB01400	Neostigmine
# DrugBank	DB01583	Liotrix
# DrugBank	DB01587	Ketazolam
# DrugBank	DB01595	Nitrazepam
# DrugBank	DB01601	Lopinavir
# DrugBank	DB02659	Cholic Acid
# DrugBank	DB04573	Estriol
# DrugBank	DB04840	Debrisoquin
# DrugBank	DB04855	Dronedarone
# DrugBank	DB04868	Nilotinib
# DrugBank	DB04877	Voacamine
# DrugBank	DB05039	Indacaterol
# DrugBank	DB05239	Cobimetinib
# DrugBank	DB05521	Telaprevir
# DrugBank	DB05773	ado-trastuzumab emtansine
# DrugBank	DB06176	Romidepsin
# DrugBank	DB06207	Silodosin
# DrugBank	DB06212	Tolvaptan
# DrugBank	DB06228	Rivaroxaban
# DrugBank	DB06287	Temsirolimus
# DrugBank	DB06290	Simeprevir
# DrugBank	DB06292	Dapagliflozin
# DrugBank	DB06403	Ambrisentan
# DrugBank	DB06414	Etravirine
# DrugBank	DB06589	Pazopanib
# DrugBank	DB06603	Panobinostat
# DrugBank	DB06605	Apixaban
# DrugBank	DB06616	Bosutinib
# DrugBank	DB06626	Axitinib
# DrugBank	DB06636	Isavuconazonium
# DrugBank	DB06695	Dabigatran etexilate
# DrugBank	DB06702	Fesoterodine
# DrugBank	DB06772	Cabazitaxel
# DrugBank	DB08816	Ticagrelor
# DrugBank	DB08820	Ivacaftor
# DrugBank	DB08827	Lomitapide
# DrugBank	DB08828	Vismodegib
# DrugBank	DB08860	Pitavastatin
# DrugBank	DB08864	Rilpivirine
# DrugBank	DB08865	Crizotinib
# DrugBank	DB08867	Ulipristal
# DrugBank	DB08870	Brentuximab vedotin
# DrugBank	DB08873	Boceprevir
# DrugBank	DB08874	Fidaxomicin
# DrugBank	DB08882	Linagliptin
# DrugBank	DB08889	Carfilzomib
# DrugBank	DB08893	Mirabegron
# DrugBank	DB08896	Regorafenib
# DrugBank	DB08899	Enzalutamide
# DrugBank	DB08901	Ponatinib
# DrugBank	DB08906	Fluticasone furoate
# DrugBank	DB08907	Canagliflozin
# DrugBank	DB08910	Pomalidomide
# DrugBank	DB08912	Dabrafenib
# DrugBank	DB08916	Afatinib
# DrugBank	DB08918	Levomilnacipran
# DrugBank	DB08934	Sofosbuvir
# DrugBank	DB09054	Idelalisib
# DrugBank	DB09063	Ceritinib
# DrugBank	DB09065	Cobicistat
# DrugBank	DB09075	Edoxaban
# DrugBank	DB09076	Umeclidinium
# DrugBank	DB09078	Lenvatinib
# DrugBank	DB09079	Nintedanib
# DrugBank	DB09102	Daclatasvir
# DrugBank	DB09291	Rolapitant
# DrugBank	DB09330	Osimertinib
# DrugBank	DB11362	Selexipag
# DrugBank	DB11363	Alectinib
# Ensembl	ENST00000265724	ENSP00000265724; ENSG00000085563. [P08183-1]
# Ensembl	ENST00000543898	ENSP00000444095; ENSG00000085563. [P08183-2]
# Ensembl	ENST00000622132	ENSP00000478255; ENSG00000085563. [P08183-1]
# ExpressionAtlas	P08183	baseline and differential
# FUNCTION	MDR1_HUMAN	Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0009986	cell surface; IDA:DFLAT.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_component	GO:0016324	apical plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005215	transporter activity; TAS:ProtInc.
# GO_function	GO:0005524	ATP binding; TAS:ProtInc.
# GO_function	GO:0008559	xenobiotic-transporting ATPase activity; TAS:Reactome.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; TAS:ProtInc.
# GO_function	GO:0090554	phosphatidylcholine-translocating ATPase activity; IDA:BHF-UCL.
# GO_function	GO:0090555	phosphatidylethanolamine-translocating ATPase activity; IDA:BHF-UCL.
# GO_function	GO:0099038	ceramide-translocating ATPase activity; IDA:BHF-UCL.
# GO_process	GO:0000086	G2/M transition of mitotic cell cycle; IDA:DFLAT.
# GO_process	GO:0002481	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; IBA:GO_Central.
# GO_process	GO:0002485	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; IBA:GO_Central.
# GO_process	GO:0002489	antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; IBA:GO_Central.
# GO_process	GO:0002591	positive regulation of antigen processing and presentation of peptide antigen via MHC class I; IBA:GO_Central.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0042493	response to drug; TAS:ProtInc.
# GO_process	GO:0045332	phospholipid translocation; IDA:BHF-UCL.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GO_process	GO:0072089	stem cell proliferation; IMP:DFLAT.
# GO_process	GO:0099040	ceramide translocation; IDA:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0008283	cell proliferation
# GOslim_process	GO:0055085	transmembrane transport
# GOslim_process	GO:0061024	membrane organization
# Gene3D	3.40.50.300	-; 2.
# Genevisible	P08183	HS
# HGNC	HGNC:40	ABCB1
# INTERACTION	MDR1_HUMAN	Q86VI4 LAPTM4B; NbExp=2; IntAct=EBI-1057359, EBI-3267258; Q99496 RNF2; NbExp=2; IntAct=EBI-1057359, EBI-722416; 
# IntAct	P08183	6
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR011527	ABC1_TM_dom
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Brite	ko04090	 Cellular antigens
# KEGG_Disease	H01529	[Skeletal dysplasia] Osteonecrosis of the femoral head
# KEGG_Pathway	ko02010	ABC transporters
# KEGG_Pathway	ko04976	Bile secretion
# MIM	171050	gene
# MIM	612244	phenotype
# Organism	MDR1_HUMAN	Homo sapiens (Human)
# Orphanet	771	Ulcerative colitis
# PIR	A34914	DVHU1
# POLYMORPHISM	MDR1_HUMAN	Genetic variation in ABCB1 may play a role in patients who do not respond to drug treatment. {ECO 0000269|PubMed 2876781, ECO 0000269|PubMed 2897240, ECO 0000269|PubMed 9038218}. 
# PROSITE	PS00211	ABC_TRANSPORTER_1; 2
# PROSITE	PS50893	ABC_TRANSPORTER_2; 2
# PROSITE	PS50929	ABC_TM1F; 2
# Pfam	PF00005	ABC_tran; 2
# Pfam	PF00664	ABC_membrane; 2
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-2161517	Abacavir transmembrane transport
# Reactome	R-HSA-382556	ABC-family proteins mediated transport
# RecName	MDR1_HUMAN	Multidrug resistance protein 1
# RefSeq	NP_000918	NM_000927.4. [P08183-1]
# SEQUENCE CAUTION	Sequence=AAM49149.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 2 ABC transmembrane type-1 domains. {ECO:0000255|PROSITE-ProRule	PRU00441}. 
# SIMILARITY	Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA; 2
# SUBCELLULAR LOCATION	MDR1_HUMAN	Cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00441}. 
# SUBUNIT	MDR1_HUMAN	Interacts with PSMB5. Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1. {ECO 0000269|PubMed 15488952, ECO 0000269|PubMed 24333728}. 
# SUPFAM	SSF52540	SSF52540; 2
# SUPFAM	SSF90123	SSF90123; 2
# TCDB	3.A.1.201	the atp-binding cassette (abc) superfamily
# TISSUE SPECIFICITY	MDR1_HUMAN	Expressed in liver, kidney, small intestine and brain. 
# UCSC	uc003uiz	human. [P08183-1]
# WEB RESOURCE	MDR1_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=P08183";
# WEB RESOURCE	MDR1_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/PGY1ID105.html"; 
# WEB RESOURCE	MDR1_HUMAN	Name=NIEHS-SNPs; URL="http //egp.gs.washington.edu/data/abcb1/"; 
# WEB RESOURCE	MDR1_HUMAN	Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http //shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=ABCB1"; 
# WEB RESOURCE	MDR1_HUMAN	Name=Wikipedia; Note=P-glycoprotein entry; URL="https //en.wikipedia.org/wiki/P-glycoprotein"; 
# eggNOG	COG1132	LUCA
# eggNOG	KOG0055	Eukaryota
BLAST	swissprot:MDR1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MDR1_HUMAN
BioCyc	ZFISH:HS01500-MONOMER	http://biocyc.org/getid?id=ZFISH:HS01500-MONOMER
COXPRESdb	5243	http://coxpresdb.jp/data/gene/5243.shtml
CleanEx	HS_ABCB1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCB1
DOI	10.1002/(SICI)1098-1004(200005)15:5<486::AID-HUMU26>3.3.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(200005)15:5<486::AID-HUMU26>3.3.CO
DOI	10.1007/s10038-002-8653-6	http://dx.doi.org/10.1007/s10038-002-8653-6
DOI	10.1016/0006-291X(89)91985-2	http://dx.doi.org/10.1016/0006-291X(89)91985-2
DOI	10.1016/0006-291X(90)90401-8	http://dx.doi.org/10.1016/0006-291X(90)90401-8
DOI	10.1016/0092-8674(86)90595-7	http://dx.doi.org/10.1016/0092-8674(86)90595-7
DOI	10.1016/0092-8674(88)90568-5	http://dx.doi.org/10.1016/0092-8674(88)90568-5
DOI	10.1016/j.canlet.2013.12.007	http://dx.doi.org/10.1016/j.canlet.2013.12.007
DOI	10.1016/j.molimm.2004.07.005	http://dx.doi.org/10.1016/j.molimm.2004.07.005
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1067/mcp.2001.114164	http://dx.doi.org/10.1067/mcp.2001.114164
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.97.7.3473	http://dx.doi.org/10.1073/pnas.97.7.3473
DOI	10.1074/jbc.272.9.5974	http://dx.doi.org/10.1074/jbc.272.9.5974
DOI	10.1086/379927	http://dx.doi.org/10.1086/379927
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1517/14622416.2.1.51	http://dx.doi.org/10.1517/14622416.2.1.51
DOI	10.2133/dmpk.17.479	http://dx.doi.org/10.2133/dmpk.17.479
DOI	10.2133/dmpk.17.566	http://dx.doi.org/10.2133/dmpk.17.566
DrugBank	DB00027	http://www.drugbank.ca/drugs/DB00027
DrugBank	DB00091	http://www.drugbank.ca/drugs/DB00091
DrugBank	DB00171	http://www.drugbank.ca/drugs/DB00171
DrugBank	DB00175	http://www.drugbank.ca/drugs/DB00175
DrugBank	DB00176	http://www.drugbank.ca/drugs/DB00176
DrugBank	DB00196	http://www.drugbank.ca/drugs/DB00196
DrugBank	DB00199	http://www.drugbank.ca/drugs/DB00199
DrugBank	DB00201	http://www.drugbank.ca/drugs/DB00201
DrugBank	DB00206	http://www.drugbank.ca/drugs/DB00206
DrugBank	DB00207	http://www.drugbank.ca/drugs/DB00207
DrugBank	DB00213	http://www.drugbank.ca/drugs/DB00213
DrugBank	DB00215	http://www.drugbank.ca/drugs/DB00215
DrugBank	DB00216	http://www.drugbank.ca/drugs/DB00216
DrugBank	DB00220	http://www.drugbank.ca/drugs/DB00220
DrugBank	DB00224	http://www.drugbank.ca/drugs/DB00224
DrugBank	DB00227	http://www.drugbank.ca/drugs/DB00227
DrugBank	DB00234	http://www.drugbank.ca/drugs/DB00234
DrugBank	DB00252	http://www.drugbank.ca/drugs/DB00252
DrugBank	DB00255	http://www.drugbank.ca/drugs/DB00255
DrugBank	DB00257	http://www.drugbank.ca/drugs/DB00257
DrugBank	DB00264	http://www.drugbank.ca/drugs/DB00264
DrugBank	DB00276	http://www.drugbank.ca/drugs/DB00276
DrugBank	DB00279	http://www.drugbank.ca/drugs/DB00279
DrugBank	DB00281	http://www.drugbank.ca/drugs/DB00281
DrugBank	DB00285	http://www.drugbank.ca/drugs/DB00285
DrugBank	DB00286	http://www.drugbank.ca/drugs/DB00286
DrugBank	DB00295	http://www.drugbank.ca/drugs/DB00295
DrugBank	DB00305	http://www.drugbank.ca/drugs/DB00305
DrugBank	DB00316	http://www.drugbank.ca/drugs/DB00316
DrugBank	DB00317	http://www.drugbank.ca/drugs/DB00317
DrugBank	DB00320	http://www.drugbank.ca/drugs/DB00320
DrugBank	DB00321	http://www.drugbank.ca/drugs/DB00321
DrugBank	DB00328	http://www.drugbank.ca/drugs/DB00328
DrugBank	DB00333	http://www.drugbank.ca/drugs/DB00333
DrugBank	DB00334	http://www.drugbank.ca/drugs/DB00334
DrugBank	DB00335	http://www.drugbank.ca/drugs/DB00335
DrugBank	DB00338	http://www.drugbank.ca/drugs/DB00338
DrugBank	DB00343	http://www.drugbank.ca/drugs/DB00343
DrugBank	DB00344	http://www.drugbank.ca/drugs/DB00344
DrugBank	DB00345	http://www.drugbank.ca/drugs/DB00345
DrugBank	DB00349	http://www.drugbank.ca/drugs/DB00349
DrugBank	DB00351	http://www.drugbank.ca/drugs/DB00351
DrugBank	DB00358	http://www.drugbank.ca/drugs/DB00358
DrugBank	DB00361	http://www.drugbank.ca/drugs/DB00361
DrugBank	DB00363	http://www.drugbank.ca/drugs/DB00363
DrugBank	DB00371	http://www.drugbank.ca/drugs/DB00371
DrugBank	DB00373	http://www.drugbank.ca/drugs/DB00373
DrugBank	DB00381	http://www.drugbank.ca/drugs/DB00381
DrugBank	DB00390	http://www.drugbank.ca/drugs/DB00390
DrugBank	DB00396	http://www.drugbank.ca/drugs/DB00396
DrugBank	DB00398	http://www.drugbank.ca/drugs/DB00398
DrugBank	DB00401	http://www.drugbank.ca/drugs/DB00401
DrugBank	DB00421	http://www.drugbank.ca/drugs/DB00421
DrugBank	DB00428	http://www.drugbank.ca/drugs/DB00428
DrugBank	DB00440	http://www.drugbank.ca/drugs/DB00440
DrugBank	DB00441	http://www.drugbank.ca/drugs/DB00441
DrugBank	DB00443	http://www.drugbank.ca/drugs/DB00443
DrugBank	DB00448	http://www.drugbank.ca/drugs/DB00448
DrugBank	DB00451	http://www.drugbank.ca/drugs/DB00451
DrugBank	DB00455	http://www.drugbank.ca/drugs/DB00455
DrugBank	DB00457	http://www.drugbank.ca/drugs/DB00457
DrugBank	DB00458	http://www.drugbank.ca/drugs/DB00458
DrugBank	DB00468	http://www.drugbank.ca/drugs/DB00468
DrugBank	DB00470	http://www.drugbank.ca/drugs/DB00470
DrugBank	DB00472	http://www.drugbank.ca/drugs/DB00472
DrugBank	DB00477	http://www.drugbank.ca/drugs/DB00477
DrugBank	DB00480	http://www.drugbank.ca/drugs/DB00480
DrugBank	DB00490	http://www.drugbank.ca/drugs/DB00490
DrugBank	DB00495	http://www.drugbank.ca/drugs/DB00495
DrugBank	DB00501	http://www.drugbank.ca/drugs/DB00501
DrugBank	DB00502	http://www.drugbank.ca/drugs/DB00502
DrugBank	DB00503	http://www.drugbank.ca/drugs/DB00503
DrugBank	DB00508	http://www.drugbank.ca/drugs/DB00508
DrugBank	DB00514	http://www.drugbank.ca/drugs/DB00514
DrugBank	DB00515	http://www.drugbank.ca/drugs/DB00515
DrugBank	DB00518	http://www.drugbank.ca/drugs/DB00518
DrugBank	DB00520	http://www.drugbank.ca/drugs/DB00520
DrugBank	DB00523	http://www.drugbank.ca/drugs/DB00523
DrugBank	DB00530	http://www.drugbank.ca/drugs/DB00530
DrugBank	DB00531	http://www.drugbank.ca/drugs/DB00531
DrugBank	DB00537	http://www.drugbank.ca/drugs/DB00537
DrugBank	DB00539	http://www.drugbank.ca/drugs/DB00539
DrugBank	DB00541	http://www.drugbank.ca/drugs/DB00541
DrugBank	DB00555	http://www.drugbank.ca/drugs/DB00555
DrugBank	DB00563	http://www.drugbank.ca/drugs/DB00563
DrugBank	DB00564	http://www.drugbank.ca/drugs/DB00564
DrugBank	DB00570	http://www.drugbank.ca/drugs/DB00570
DrugBank	DB00571	http://www.drugbank.ca/drugs/DB00571
DrugBank	DB00575	http://www.drugbank.ca/drugs/DB00575
DrugBank	DB00584	http://www.drugbank.ca/drugs/DB00584
DrugBank	DB00585	http://www.drugbank.ca/drugs/DB00585
DrugBank	DB00586	http://www.drugbank.ca/drugs/DB00586
DrugBank	DB00590	http://www.drugbank.ca/drugs/DB00590
DrugBank	DB00602	http://www.drugbank.ca/drugs/DB00602
DrugBank	DB00608	http://www.drugbank.ca/drugs/DB00608
DrugBank	DB00619	http://www.drugbank.ca/drugs/DB00619
DrugBank	DB00622	http://www.drugbank.ca/drugs/DB00622
DrugBank	DB00623	http://www.drugbank.ca/drugs/DB00623
DrugBank	DB00624	http://www.drugbank.ca/drugs/DB00624
DrugBank	DB00635	http://www.drugbank.ca/drugs/DB00635
DrugBank	DB00637	http://www.drugbank.ca/drugs/DB00637
DrugBank	DB00641	http://www.drugbank.ca/drugs/DB00641
DrugBank	DB00643	http://www.drugbank.ca/drugs/DB00643
DrugBank	DB00655	http://www.drugbank.ca/drugs/DB00655
DrugBank	DB00656	http://www.drugbank.ca/drugs/DB00656
DrugBank	DB00661	http://www.drugbank.ca/drugs/DB00661
DrugBank	DB00669	http://www.drugbank.ca/drugs/DB00669
DrugBank	DB00672	http://www.drugbank.ca/drugs/DB00672
DrugBank	DB00675	http://www.drugbank.ca/drugs/DB00675
DrugBank	DB00678	http://www.drugbank.ca/drugs/DB00678
DrugBank	DB00683	http://www.drugbank.ca/drugs/DB00683
DrugBank	DB00688	http://www.drugbank.ca/drugs/DB00688
DrugBank	DB00690	http://www.drugbank.ca/drugs/DB00690
DrugBank	DB00694	http://www.drugbank.ca/drugs/DB00694
DrugBank	DB00696	http://www.drugbank.ca/drugs/DB00696
DrugBank	DB00701	http://www.drugbank.ca/drugs/DB00701
DrugBank	DB00704	http://www.drugbank.ca/drugs/DB00704
DrugBank	DB00709	http://www.drugbank.ca/drugs/DB00709
DrugBank	DB00715	http://www.drugbank.ca/drugs/DB00715
DrugBank	DB00717	http://www.drugbank.ca/drugs/DB00717
DrugBank	DB00722	http://www.drugbank.ca/drugs/DB00722
DrugBank	DB00726	http://www.drugbank.ca/drugs/DB00726
DrugBank	DB00734	http://www.drugbank.ca/drugs/DB00734
DrugBank	DB00741	http://www.drugbank.ca/drugs/DB00741
DrugBank	DB00742	http://www.drugbank.ca/drugs/DB00742
DrugBank	DB00747	http://www.drugbank.ca/drugs/DB00747
DrugBank	DB00751	http://www.drugbank.ca/drugs/DB00751
DrugBank	DB00758	http://www.drugbank.ca/drugs/DB00758
DrugBank	DB00762	http://www.drugbank.ca/drugs/DB00762
DrugBank	DB00773	http://www.drugbank.ca/drugs/DB00773
DrugBank	DB00778	http://www.drugbank.ca/drugs/DB00778
DrugBank	DB00783	http://www.drugbank.ca/drugs/DB00783
DrugBank	DB00790	http://www.drugbank.ca/drugs/DB00790
DrugBank	DB00796	http://www.drugbank.ca/drugs/DB00796
DrugBank	DB00802	http://www.drugbank.ca/drugs/DB00802
DrugBank	DB00810	http://www.drugbank.ca/drugs/DB00810
DrugBank	DB00813	http://www.drugbank.ca/drugs/DB00813
DrugBank	DB00829	http://www.drugbank.ca/drugs/DB00829
DrugBank	DB00831	http://www.drugbank.ca/drugs/DB00831
DrugBank	DB00834	http://www.drugbank.ca/drugs/DB00834
DrugBank	DB00836	http://www.drugbank.ca/drugs/DB00836
DrugBank	DB00845	http://www.drugbank.ca/drugs/DB00845
DrugBank	DB00860	http://www.drugbank.ca/drugs/DB00860
DrugBank	DB00863	http://www.drugbank.ca/drugs/DB00863
DrugBank	DB00864	http://www.drugbank.ca/drugs/DB00864
DrugBank	DB00875	http://www.drugbank.ca/drugs/DB00875
DrugBank	DB00877	http://www.drugbank.ca/drugs/DB00877
DrugBank	DB00882	http://www.drugbank.ca/drugs/DB00882
DrugBank	DB00908	http://www.drugbank.ca/drugs/DB00908
DrugBank	DB00915	http://www.drugbank.ca/drugs/DB00915
DrugBank	DB00921	http://www.drugbank.ca/drugs/DB00921
DrugBank	DB00934	http://www.drugbank.ca/drugs/DB00934
DrugBank	DB00936	http://www.drugbank.ca/drugs/DB00936
DrugBank	DB00945	http://www.drugbank.ca/drugs/DB00945
DrugBank	DB00950	http://www.drugbank.ca/drugs/DB00950
DrugBank	DB00959	http://www.drugbank.ca/drugs/DB00959
DrugBank	DB00966	http://www.drugbank.ca/drugs/DB00966
DrugBank	DB00967	http://www.drugbank.ca/drugs/DB00967
DrugBank	DB00970	http://www.drugbank.ca/drugs/DB00970
DrugBank	DB00972	http://www.drugbank.ca/drugs/DB00972
DrugBank	DB00973	http://www.drugbank.ca/drugs/DB00973
DrugBank	DB00975	http://www.drugbank.ca/drugs/DB00975
DrugBank	DB00977	http://www.drugbank.ca/drugs/DB00977
DrugBank	DB00997	http://www.drugbank.ca/drugs/DB00997
DrugBank	DB01016	http://www.drugbank.ca/drugs/DB01016
DrugBank	DB01023	http://www.drugbank.ca/drugs/DB01023
DrugBank	DB01026	http://www.drugbank.ca/drugs/DB01026
DrugBank	DB01030	http://www.drugbank.ca/drugs/DB01030
DrugBank	DB01032	http://www.drugbank.ca/drugs/DB01032
DrugBank	DB01037	http://www.drugbank.ca/drugs/DB01037
DrugBank	DB01045	http://www.drugbank.ca/drugs/DB01045
DrugBank	DB01050	http://www.drugbank.ca/drugs/DB01050
DrugBank	DB01054	http://www.drugbank.ca/drugs/DB01054
DrugBank	DB01069	http://www.drugbank.ca/drugs/DB01069
DrugBank	DB01072	http://www.drugbank.ca/drugs/DB01072
DrugBank	DB01076	http://www.drugbank.ca/drugs/DB01076
DrugBank	DB01086	http://www.drugbank.ca/drugs/DB01086
DrugBank	DB01100	http://www.drugbank.ca/drugs/DB01100
DrugBank	DB01103	http://www.drugbank.ca/drugs/DB01103
DrugBank	DB01104	http://www.drugbank.ca/drugs/DB01104
DrugBank	DB01110	http://www.drugbank.ca/drugs/DB01110
DrugBank	DB01115	http://www.drugbank.ca/drugs/DB01115
DrugBank	DB01118	http://www.drugbank.ca/drugs/DB01118
DrugBank	DB01136	http://www.drugbank.ca/drugs/DB01136
DrugBank	DB01137	http://www.drugbank.ca/drugs/DB01137
DrugBank	DB01138	http://www.drugbank.ca/drugs/DB01138
DrugBank	DB01142	http://www.drugbank.ca/drugs/DB01142
DrugBank	DB01149	http://www.drugbank.ca/drugs/DB01149
DrugBank	DB01151	http://www.drugbank.ca/drugs/DB01151
DrugBank	DB01162	http://www.drugbank.ca/drugs/DB01162
DrugBank	DB01167	http://www.drugbank.ca/drugs/DB01167
DrugBank	DB01169	http://www.drugbank.ca/drugs/DB01169
DrugBank	DB01174	http://www.drugbank.ca/drugs/DB01174
DrugBank	DB01182	http://www.drugbank.ca/drugs/DB01182
DrugBank	DB01183	http://www.drugbank.ca/drugs/DB01183
DrugBank	DB01184	http://www.drugbank.ca/drugs/DB01184
DrugBank	DB01193	http://www.drugbank.ca/drugs/DB01193
DrugBank	DB01196	http://www.drugbank.ca/drugs/DB01196
DrugBank	DB01197	http://www.drugbank.ca/drugs/DB01197
DrugBank	DB01200	http://www.drugbank.ca/drugs/DB01200
DrugBank	DB01202	http://www.drugbank.ca/drugs/DB01202
DrugBank	DB01203	http://www.drugbank.ca/drugs/DB01203
DrugBank	DB01204	http://www.drugbank.ca/drugs/DB01204
DrugBank	DB01208	http://www.drugbank.ca/drugs/DB01208
DrugBank	DB01211	http://www.drugbank.ca/drugs/DB01211
DrugBank	DB01221	http://www.drugbank.ca/drugs/DB01221
DrugBank	DB01224	http://www.drugbank.ca/drugs/DB01224
DrugBank	DB01229	http://www.drugbank.ca/drugs/DB01229
DrugBank	DB01232	http://www.drugbank.ca/drugs/DB01232
DrugBank	DB01234	http://www.drugbank.ca/drugs/DB01234
DrugBank	DB01239	http://www.drugbank.ca/drugs/DB01239
DrugBank	DB01242	http://www.drugbank.ca/drugs/DB01242
DrugBank	DB01244	http://www.drugbank.ca/drugs/DB01244
DrugBank	DB01248	http://www.drugbank.ca/drugs/DB01248
DrugBank	DB01253	http://www.drugbank.ca/drugs/DB01253
DrugBank	DB01254	http://www.drugbank.ca/drugs/DB01254
DrugBank	DB01259	http://www.drugbank.ca/drugs/DB01259
DrugBank	DB01261	http://www.drugbank.ca/drugs/DB01261
DrugBank	DB01263	http://www.drugbank.ca/drugs/DB01263
DrugBank	DB01268	http://www.drugbank.ca/drugs/DB01268
DrugBank	DB01339	http://www.drugbank.ca/drugs/DB01339
DrugBank	DB01340	http://www.drugbank.ca/drugs/DB01340
DrugBank	DB01361	http://www.drugbank.ca/drugs/DB01361
DrugBank	DB01394	http://www.drugbank.ca/drugs/DB01394
DrugBank	DB01396	http://www.drugbank.ca/drugs/DB01396
DrugBank	DB01400	http://www.drugbank.ca/drugs/DB01400
DrugBank	DB01583	http://www.drugbank.ca/drugs/DB01583
DrugBank	DB01587	http://www.drugbank.ca/drugs/DB01587
DrugBank	DB01595	http://www.drugbank.ca/drugs/DB01595
DrugBank	DB01601	http://www.drugbank.ca/drugs/DB01601
DrugBank	DB02659	http://www.drugbank.ca/drugs/DB02659
DrugBank	DB04573	http://www.drugbank.ca/drugs/DB04573
DrugBank	DB04840	http://www.drugbank.ca/drugs/DB04840
DrugBank	DB04855	http://www.drugbank.ca/drugs/DB04855
DrugBank	DB04868	http://www.drugbank.ca/drugs/DB04868
DrugBank	DB04877	http://www.drugbank.ca/drugs/DB04877
DrugBank	DB05039	http://www.drugbank.ca/drugs/DB05039
DrugBank	DB05239	http://www.drugbank.ca/drugs/DB05239
DrugBank	DB05521	http://www.drugbank.ca/drugs/DB05521
DrugBank	DB05773	http://www.drugbank.ca/drugs/DB05773
DrugBank	DB06176	http://www.drugbank.ca/drugs/DB06176
DrugBank	DB06207	http://www.drugbank.ca/drugs/DB06207
DrugBank	DB06212	http://www.drugbank.ca/drugs/DB06212
DrugBank	DB06228	http://www.drugbank.ca/drugs/DB06228
DrugBank	DB06287	http://www.drugbank.ca/drugs/DB06287
DrugBank	DB06290	http://www.drugbank.ca/drugs/DB06290
DrugBank	DB06292	http://www.drugbank.ca/drugs/DB06292
DrugBank	DB06403	http://www.drugbank.ca/drugs/DB06403
DrugBank	DB06414	http://www.drugbank.ca/drugs/DB06414
DrugBank	DB06589	http://www.drugbank.ca/drugs/DB06589
DrugBank	DB06603	http://www.drugbank.ca/drugs/DB06603
DrugBank	DB06605	http://www.drugbank.ca/drugs/DB06605
DrugBank	DB06616	http://www.drugbank.ca/drugs/DB06616
DrugBank	DB06626	http://www.drugbank.ca/drugs/DB06626
DrugBank	DB06636	http://www.drugbank.ca/drugs/DB06636
DrugBank	DB06695	http://www.drugbank.ca/drugs/DB06695
DrugBank	DB06702	http://www.drugbank.ca/drugs/DB06702
DrugBank	DB06772	http://www.drugbank.ca/drugs/DB06772
DrugBank	DB08816	http://www.drugbank.ca/drugs/DB08816
DrugBank	DB08820	http://www.drugbank.ca/drugs/DB08820
DrugBank	DB08827	http://www.drugbank.ca/drugs/DB08827
DrugBank	DB08828	http://www.drugbank.ca/drugs/DB08828
DrugBank	DB08860	http://www.drugbank.ca/drugs/DB08860
DrugBank	DB08864	http://www.drugbank.ca/drugs/DB08864
DrugBank	DB08865	http://www.drugbank.ca/drugs/DB08865
DrugBank	DB08867	http://www.drugbank.ca/drugs/DB08867
DrugBank	DB08870	http://www.drugbank.ca/drugs/DB08870
DrugBank	DB08873	http://www.drugbank.ca/drugs/DB08873
DrugBank	DB08874	http://www.drugbank.ca/drugs/DB08874
DrugBank	DB08882	http://www.drugbank.ca/drugs/DB08882
DrugBank	DB08889	http://www.drugbank.ca/drugs/DB08889
DrugBank	DB08893	http://www.drugbank.ca/drugs/DB08893
DrugBank	DB08896	http://www.drugbank.ca/drugs/DB08896
DrugBank	DB08899	http://www.drugbank.ca/drugs/DB08899
DrugBank	DB08901	http://www.drugbank.ca/drugs/DB08901
DrugBank	DB08906	http://www.drugbank.ca/drugs/DB08906
DrugBank	DB08907	http://www.drugbank.ca/drugs/DB08907
DrugBank	DB08910	http://www.drugbank.ca/drugs/DB08910
DrugBank	DB08912	http://www.drugbank.ca/drugs/DB08912
DrugBank	DB08916	http://www.drugbank.ca/drugs/DB08916
DrugBank	DB08918	http://www.drugbank.ca/drugs/DB08918
DrugBank	DB08934	http://www.drugbank.ca/drugs/DB08934
DrugBank	DB09054	http://www.drugbank.ca/drugs/DB09054
DrugBank	DB09063	http://www.drugbank.ca/drugs/DB09063
DrugBank	DB09065	http://www.drugbank.ca/drugs/DB09065
DrugBank	DB09075	http://www.drugbank.ca/drugs/DB09075
DrugBank	DB09076	http://www.drugbank.ca/drugs/DB09076
DrugBank	DB09078	http://www.drugbank.ca/drugs/DB09078
DrugBank	DB09079	http://www.drugbank.ca/drugs/DB09079
DrugBank	DB09102	http://www.drugbank.ca/drugs/DB09102
DrugBank	DB09291	http://www.drugbank.ca/drugs/DB09291
DrugBank	DB09330	http://www.drugbank.ca/drugs/DB09330
DrugBank	DB11362	http://www.drugbank.ca/drugs/DB11362
DrugBank	DB11363	http://www.drugbank.ca/drugs/DB11363
EC_number	EC:3.6.3.44	http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.44
EMBL	AC002457	http://www.ebi.ac.uk/ena/data/view/AC002457
EMBL	AC005068	http://www.ebi.ac.uk/ena/data/view/AC005068
EMBL	AF016535	http://www.ebi.ac.uk/ena/data/view/AF016535
EMBL	AK290159	http://www.ebi.ac.uk/ena/data/view/AK290159
EMBL	AY910577	http://www.ebi.ac.uk/ena/data/view/AY910577
EMBL	EU854148	http://www.ebi.ac.uk/ena/data/view/EU854148
EMBL	M14758	http://www.ebi.ac.uk/ena/data/view/M14758
EMBL	M29424	http://www.ebi.ac.uk/ena/data/view/M29424
EMBL	M29425	http://www.ebi.ac.uk/ena/data/view/M29425
EMBL	M29426	http://www.ebi.ac.uk/ena/data/view/M29426
EMBL	M29427	http://www.ebi.ac.uk/ena/data/view/M29427
EMBL	M29428	http://www.ebi.ac.uk/ena/data/view/M29428
EMBL	M29429	http://www.ebi.ac.uk/ena/data/view/M29429
EMBL	M29430	http://www.ebi.ac.uk/ena/data/view/M29430
EMBL	M29431	http://www.ebi.ac.uk/ena/data/view/M29431
EMBL	M29432	http://www.ebi.ac.uk/ena/data/view/M29432
EMBL	M29433	http://www.ebi.ac.uk/ena/data/view/M29433
EMBL	M29434	http://www.ebi.ac.uk/ena/data/view/M29434
EMBL	M29435	http://www.ebi.ac.uk/ena/data/view/M29435
EMBL	M29436	http://www.ebi.ac.uk/ena/data/view/M29436
EMBL	M29437	http://www.ebi.ac.uk/ena/data/view/M29437
EMBL	M29438	http://www.ebi.ac.uk/ena/data/view/M29438
EMBL	M29439	http://www.ebi.ac.uk/ena/data/view/M29439
EMBL	M29440	http://www.ebi.ac.uk/ena/data/view/M29440
EMBL	M29441	http://www.ebi.ac.uk/ena/data/view/M29441
EMBL	M29442	http://www.ebi.ac.uk/ena/data/view/M29442
EMBL	M29443	http://www.ebi.ac.uk/ena/data/view/M29443
EMBL	M29444	http://www.ebi.ac.uk/ena/data/view/M29444
EMBL	M29445	http://www.ebi.ac.uk/ena/data/view/M29445
EMBL	M29446	http://www.ebi.ac.uk/ena/data/view/M29446
EMBL	M29447	http://www.ebi.ac.uk/ena/data/view/M29447
EMBL	M37724	http://www.ebi.ac.uk/ena/data/view/M37724
EMBL	M37725	http://www.ebi.ac.uk/ena/data/view/M37725
EMBL	X58723	http://www.ebi.ac.uk/ena/data/view/X58723
ENZYME	3.6.3.44	http://enzyme.expasy.org/EC/3.6.3.44
Ensembl	ENST00000265724	http://www.ensembl.org/id/ENST00000265724
Ensembl	ENST00000543898	http://www.ensembl.org/id/ENST00000543898
Ensembl	ENST00000622132	http://www.ensembl.org/id/ENST00000622132
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0008559	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008559
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GO_function	GO:0090554	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090554
GO_function	GO:0090555	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090555
GO_function	GO:0099038	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0099038
GO_process	GO:0000086	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000086
GO_process	GO:0002481	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002481
GO_process	GO:0002485	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002485
GO_process	GO:0002489	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002489
GO_process	GO:0002591	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002591
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0045332	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045332
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GO_process	GO:0072089	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072089
GO_process	GO:0099040	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0099040
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0008283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008283
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCB1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCB1
GeneID	5243	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5243
GeneTree	ENSGT00530000062896	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062896
H-InvDB	HIX0033521	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0033521
HGNC	HGNC:40	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:40
HOVERGEN	HBG080809	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG080809&db=HOVERGEN
HPA	CAB001716	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB001716
HPA	HPA002199	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA002199
InParanoid	P08183	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08183
IntAct	P08183	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08183*
IntEnz	3.6.3.44	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.44
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR011527	http://www.ebi.ac.uk/interpro/entry/IPR011527
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	5243	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=5243
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko04090	http://www.genome.jp/dbget-bin/www_bget?ko04090
KEGG_Disease	H01529	http://www.genome.jp/dbget-bin/www_bget?H01529
KEGG_Gene	hsa:5243	http://www.genome.jp/dbget-bin/www_bget?hsa:5243
KEGG_Orthology	KO:K05658	http://www.genome.jp/dbget-bin/www_bget?KO:K05658
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
MIM	171050	http://www.ncbi.nlm.nih.gov/omim/171050
MIM	612244	http://www.ncbi.nlm.nih.gov/omim/612244
MINT	MINT-5000901	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5000901
OMA	SQGQDRK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SQGQDRK
Orphanet	771	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=771
OrthoDB	EOG091G0HVA	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0HVA
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PROSITE	PS50929	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929
PSORT	swissprot:MDR1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MDR1_HUMAN
PSORT-B	swissprot:MDR1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MDR1_HUMAN
PSORT2	swissprot:MDR1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MDR1_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF00664	http://pfam.xfam.org/family/PF00664
PharmGKB	PA267	http://www.pharmgkb.org/do/serve?objId=PA267&objCls=Gene
Phobius	swissprot:MDR1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MDR1_HUMAN
PhylomeDB	P08183	http://phylomedb.org/?seqid=P08183
ProteinModelPortal	P08183	http://www.proteinmodelportal.org/query/uniprot/P08183
PubMed	10716719	http://www.ncbi.nlm.nih.gov/pubmed/10716719
PubMed	10790226	http://www.ncbi.nlm.nih.gov/pubmed/10790226
PubMed	11240981	http://www.ncbi.nlm.nih.gov/pubmed/11240981
PubMed	11258197	http://www.ncbi.nlm.nih.gov/pubmed/11258197
PubMed	11829140	http://www.ncbi.nlm.nih.gov/pubmed/11829140
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	14610718	http://www.ncbi.nlm.nih.gov/pubmed/14610718
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15488952	http://www.ncbi.nlm.nih.gov/pubmed/15488952
PubMed	15618700	http://www.ncbi.nlm.nih.gov/pubmed/15618700
PubMed	15618713	http://www.ncbi.nlm.nih.gov/pubmed/15618713
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	1967175	http://www.ncbi.nlm.nih.gov/pubmed/1967175
PubMed	1972623	http://www.ncbi.nlm.nih.gov/pubmed/1972623
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	24333728	http://www.ncbi.nlm.nih.gov/pubmed/24333728
PubMed	2568832	http://www.ncbi.nlm.nih.gov/pubmed/2568832
PubMed	2876781	http://www.ncbi.nlm.nih.gov/pubmed/2876781
PubMed	2897240	http://www.ncbi.nlm.nih.gov/pubmed/2897240
PubMed	9038218	http://www.ncbi.nlm.nih.gov/pubmed/9038218
PubMed	9473242	http://www.ncbi.nlm.nih.gov/pubmed/9473242
Reactome	R-HSA-2161517	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2161517
Reactome	R-HSA-382556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-382556
RefSeq	NP_000918	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000918
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	P08183	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08183
STRING	9606.ENSP00000265724	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000265724&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
SUPFAM	SSF90123	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123
TCDB	3.A.1.201	http://www.tcdb.org/search/result.php?tc=3.A.1.201
UCSC	uc003uiz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003uiz&org=rat
UniGene	Hs.489033	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.489033
UniGene	Hs.689936	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.689936
UniGene	Hs.737655	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.737655
UniProtKB	MDR1_HUMAN	http://www.uniprot.org/uniprot/MDR1_HUMAN
UniProtKB-AC	P08183	http://www.uniprot.org/uniprot/P08183
charge	swissprot:MDR1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MDR1_HUMAN
eggNOG	COG1132	http://eggnogapi.embl.de/nog_data/html/tree/COG1132
eggNOG	KOG0055	http://eggnogapi.embl.de/nog_data/html/tree/KOG0055
epestfind	swissprot:MDR1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MDR1_HUMAN
garnier	swissprot:MDR1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MDR1_HUMAN
helixturnhelix	swissprot:MDR1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MDR1_HUMAN
hmoment	swissprot:MDR1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MDR1_HUMAN
iep	swissprot:MDR1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MDR1_HUMAN
inforesidue	swissprot:MDR1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MDR1_HUMAN
neXtProt	NX_P08183	http://www.nextprot.org/db/entry/NX_P08183
octanol	swissprot:MDR1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MDR1_HUMAN
pepcoil	swissprot:MDR1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MDR1_HUMAN
pepdigest	swissprot:MDR1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MDR1_HUMAN
pepinfo	swissprot:MDR1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MDR1_HUMAN
pepnet	swissprot:MDR1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MDR1_HUMAN
pepstats	swissprot:MDR1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MDR1_HUMAN
pepwheel	swissprot:MDR1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MDR1_HUMAN
pepwindow	swissprot:MDR1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MDR1_HUMAN
sigcleave	swissprot:MDR1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MDR1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	B3A2_HUMAN	Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist.; Name=A; IsoId=P04920-1; Sequence=Displayed; Name=B1; IsoId=P04920-2; Sequence=VSP_000456; Name=3; IsoId=P04920-3; Sequence=VSP_045953; Note=No experimental confirmation available.; 
# AltName	B3A2_HUMAN	Non-erythroid band 3-like protein
# AltName	B3A2_HUMAN	Solute carrier family 4 member 2
# BioGrid	112413	31
# CCDS	CCDS56520	-. [P04920-3]
# CCDS	CCDS56521	-. [P04920-2]
# CCDS	CCDS5917	-. [P04920-1]
# ChiTaRS	SLC4A2	human
# Ensembl	ENST00000392826	ENSP00000376571; ENSG00000164889. [P04920-3]
# Ensembl	ENST00000413384	ENSP00000405600; ENSG00000164889. [P04920-1]
# Ensembl	ENST00000461735	ENSP00000419164; ENSG00000164889. [P04920-2]
# Ensembl	ENST00000485713	ENSP00000419412; ENSG00000164889. [P04920-1]
# ExpressionAtlas	P04920	baseline and differential
# FUNCTION	B3A2_HUMAN	Plasma membrane anion exchange protein of wide distribution. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0005925	focal adhesion; IDA:UniProtKB.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:Ensembl.
# GO_component	GO:0016324	apical plasma membrane; IEA:Ensembl.
# GO_function	B3A2_HUMAN	GO 0015301 anion anion antiporter activity; IEA UniProtKB-KW.
# GO_function	GO:0005452	inorganic anion exchanger activity; TAS:Reactome.
# GO_function	GO:0008509	anion transmembrane transporter activity; TAS:ProtInc.
# GO_process	GO:0006820	anion transport; TAS:ProtInc.
# GO_process	GO:0007283	spermatogenesis; IEA:Ensembl.
# GO_process	GO:0015701	bicarbonate transport; TAS:Reactome.
# GO_process	GO:0048565	digestive tract development; IEA:Ensembl.
# GO_process	GO:0051453	regulation of intracellular pH; IBA:GO_Central.
# GO_process	GO:1902476	chloride transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.1100.10	-; 1.
# Genevisible	P04920	HS
# HGNC	HGNC:11028	SLC4A2
# IntAct	P04920	17
# InterPro	IPR001717	Anion_exchange
# InterPro	IPR002978	Anion_exchange_2
# InterPro	IPR003020	HCO3_transpt_euk
# InterPro	IPR011531	HCO3_transpt_C
# InterPro	IPR013769	Band3_cytoplasmic_dom
# InterPro	IPR016152	PTrfase/Anion_transptr
# InterPro	IPR018241	Anion_exchange_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04970	Salivary secretion
# KEGG_Pathway	ko04971	Gastric acid secretion
# KEGG_Pathway	ko04972	Pancreatic secretion
# KEGG_Pathway	ko04976	Bile secretion
# MIM	109280	gene
# Organism	B3A2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11453	PTHR11453; 2
# PANTHER	PTHR11453:SF14	PTHR11453:SF14; 2
# PIR	S21086	S21086
# PRINTS	PR00165	ANIONEXCHNGR
# PRINTS	PR01188	ANIONEXHNGR2
# PRINTS	PR01231	HCO3TRNSPORT
# PROSITE	PS00219	ANION_EXCHANGER_1
# PROSITE	PS00220	ANION_EXCHANGER_2
# Pfam	PF00955	HCO3_cotransp
# Pfam	PF07565	Band_3_cyto
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-425381	Bicarbonate transporters
# RecName	B3A2_HUMAN	Anion exchange protein 2
# RefSeq	NP_001186621	NM_001199692.1. [P04920-1]
# RefSeq	NP_001186622	NM_001199693.1. [P04920-3]
# RefSeq	NP_001186623	NM_001199694.1. [P04920-2]
# RefSeq	NP_003031	NM_003040.3. [P04920-1]
# SIMILARITY	Belongs to the anion exchanger (TC 2.A.31) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	B3A2_HUMAN	Membrane; Multi-pass membrane protein. 
# SUPFAM	SSF55804	SSF55804; 2
# TCDB	2.A.31.1	the anion exchanger (ae) family
# TIGRFAMs	TIGR00834	ae
# UCSC	uc003wit	human. [P04920-1]
# WEB RESOURCE	B3A2_HUMAN	Name=NIEHS-SNPs; URL="http //egp.gs.washington.edu/data/slc4a2/";
# eggNOG	ENOG410XPHD	LUCA
# eggNOG	KOG1172	Eukaryota
BLAST	swissprot:B3A2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:B3A2_HUMAN
BioCyc	ZFISH:ENSG00000164889-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000164889-MONOMER
COXPRESdb	6522	http://coxpresdb.jp/data/gene/6522.shtml
CleanEx	HS_SLC4A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC4A2
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/0167-4781(92)90446-7	http://dx.doi.org/10.1016/0167-4781(92)90446-7
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/mcp.O113.027870	http://dx.doi.org/10.1074/mcp.O113.027870
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
EMBL	AC010973	http://www.ebi.ac.uk/ena/data/view/AC010973
EMBL	AK295767	http://www.ebi.ac.uk/ena/data/view/AK295767
EMBL	AK312699	http://www.ebi.ac.uk/ena/data/view/AK312699
EMBL	BC009386	http://www.ebi.ac.uk/ena/data/view/BC009386
EMBL	BC009434	http://www.ebi.ac.uk/ena/data/view/BC009434
EMBL	CH471173	http://www.ebi.ac.uk/ena/data/view/CH471173
EMBL	CH471173	http://www.ebi.ac.uk/ena/data/view/CH471173
EMBL	DQ149844	http://www.ebi.ac.uk/ena/data/view/DQ149844
EMBL	X03918	http://www.ebi.ac.uk/ena/data/view/X03918
EMBL	X62137	http://www.ebi.ac.uk/ena/data/view/X62137
Ensembl	ENST00000392826	http://www.ensembl.org/id/ENST00000392826
Ensembl	ENST00000413384	http://www.ensembl.org/id/ENST00000413384
Ensembl	ENST00000461735	http://www.ensembl.org/id/ENST00000461735
Ensembl	ENST00000485713	http://www.ensembl.org/id/ENST00000485713
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005925	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005925
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_function	GO:0005452	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005452
GO_function	GO:0008509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008509
GO_function	GO:0015301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015301
GO_process	GO:0006820	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006820
GO_process	GO:0007283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007283
GO_process	GO:0015701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015701
GO_process	GO:0048565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048565
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.1100.10	http://www.cathdb.info/version/latest/superfamily/3.40.1100.10
GeneCards	SLC4A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC4A2
GeneID	6522	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6522
GeneTree	ENSGT00760000119021	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119021
HGNC	HGNC:11028	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11028
HOGENOM	HOG000280683	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280683&db=HOGENOM6
HOVERGEN	HBG004326	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004326&db=HOVERGEN
HPA	HPA019339	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA019339
InParanoid	P04920	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P04920
IntAct	P04920	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P04920*
InterPro	IPR001717	http://www.ebi.ac.uk/interpro/entry/IPR001717
InterPro	IPR002978	http://www.ebi.ac.uk/interpro/entry/IPR002978
InterPro	IPR003020	http://www.ebi.ac.uk/interpro/entry/IPR003020
InterPro	IPR011531	http://www.ebi.ac.uk/interpro/entry/IPR011531
InterPro	IPR013769	http://www.ebi.ac.uk/interpro/entry/IPR013769
InterPro	IPR016152	http://www.ebi.ac.uk/interpro/entry/IPR016152
InterPro	IPR018241	http://www.ebi.ac.uk/interpro/entry/IPR018241
Jabion	6522	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6522
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6522	http://www.genome.jp/dbget-bin/www_bget?hsa:6522
KEGG_Orthology	KO:K13855	http://www.genome.jp/dbget-bin/www_bget?KO:K13855
KEGG_Pathway	ko04970	http://www.genome.jp/kegg-bin/show_pathway?ko04970
KEGG_Pathway	ko04971	http://www.genome.jp/kegg-bin/show_pathway?ko04971
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
MIM	109280	http://www.ncbi.nlm.nih.gov/omim/109280
OMA	ANEHFHS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ANEHFHS
OrthoDB	EOG091G01FT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01FT
PANTHER	PTHR11453	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11453
PANTHER	PTHR11453:SF14	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11453:SF14
PRINTS	PR00165	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00165
PRINTS	PR01188	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01188
PRINTS	PR01231	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01231
PROSITE	PS00219	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00219
PROSITE	PS00220	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00220
PSORT	swissprot:B3A2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:B3A2_HUMAN
PSORT-B	swissprot:B3A2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:B3A2_HUMAN
PSORT2	swissprot:B3A2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:B3A2_HUMAN
Pfam	PF00955	http://pfam.xfam.org/family/PF00955
Pfam	PF07565	http://pfam.xfam.org/family/PF07565
PharmGKB	PA35896	http://www.pharmgkb.org/do/serve?objId=PA35896&objCls=Gene
Phobius	swissprot:B3A2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:B3A2_HUMAN
PhylomeDB	P04920	http://phylomedb.org/?seqid=P04920
ProteinModelPortal	P04920	http://www.proteinmodelportal.org/query/uniprot/P04920
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	1562608	http://www.ncbi.nlm.nih.gov/pubmed/1562608
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24129315	http://www.ncbi.nlm.nih.gov/pubmed/24129315
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	3015590	http://www.ncbi.nlm.nih.gov/pubmed/3015590
Reactome	R-HSA-425381	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425381
RefSeq	NP_001186621	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001186621
RefSeq	NP_001186622	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001186622
RefSeq	NP_001186623	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001186623
RefSeq	NP_003031	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003031
SMR	P04920	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P04920
STRING	9606.ENSP00000405600	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000405600&targetmode=cogs
SUPFAM	SSF55804	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55804
TCDB	2.A.31.1	http://www.tcdb.org/search/result.php?tc=2.A.31.1
TIGRFAMs	TIGR00834	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00834
UCSC	uc003wit	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003wit&org=rat
UniGene	Hs.647069	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.647069
UniProtKB	B3A2_HUMAN	http://www.uniprot.org/uniprot/B3A2_HUMAN
UniProtKB-AC	P04920	http://www.uniprot.org/uniprot/P04920
charge	swissprot:B3A2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:B3A2_HUMAN
eggNOG	ENOG410XPHD	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPHD
eggNOG	KOG1172	http://eggnogapi.embl.de/nog_data/html/tree/KOG1172
epestfind	swissprot:B3A2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:B3A2_HUMAN
garnier	swissprot:B3A2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:B3A2_HUMAN
helixturnhelix	swissprot:B3A2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:B3A2_HUMAN
hmoment	swissprot:B3A2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:B3A2_HUMAN
iep	swissprot:B3A2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:B3A2_HUMAN
inforesidue	swissprot:B3A2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:B3A2_HUMAN
neXtProt	NX_P04920	http://www.nextprot.org/db/entry/NX_P04920
octanol	swissprot:B3A2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:B3A2_HUMAN
pepcoil	swissprot:B3A2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:B3A2_HUMAN
pepdigest	swissprot:B3A2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:B3A2_HUMAN
pepinfo	swissprot:B3A2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:B3A2_HUMAN
pepnet	swissprot:B3A2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:B3A2_HUMAN
pepstats	swissprot:B3A2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:B3A2_HUMAN
pepwheel	swissprot:B3A2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:B3A2_HUMAN
pepwindow	swissprot:B3A2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:B3A2_HUMAN
sigcleave	swissprot:B3A2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:B3A2_HUMAN
## Database	ID	URL or Descriptions
# AltName	LRC8D_HUMAN	Leucine-rich repeat-containing protein 5
# AltName	LRC8D_HUMAN	Leucine-rich repeat-containing protein 8D
# BioGrid	120447	5
# ChiTaRS	LRRC8D	human
# Ensembl	ENST00000337338	ENSP00000338887; ENSG00000171492
# Ensembl	ENST00000394593	ENSP00000378093; ENSG00000171492
# ExpressionAtlas	Q7L1W4	baseline and differential
# FUNCTION	LRC8D_HUMAN	Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed 24790029, PubMed 26824658). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed 26530471). Mediates the import of the antibiotic blasticidin-S into the cell (PubMed 24782309). {ECO 0000269|PubMed 24782309, ECO 0000269|PubMed 24790029, ECO 0000269|PubMed 26530471, ECO 0000269|PubMed 26824658}. 
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005789	endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IMP:UniProtKB.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_function	GO:0005225	volume-sensitive anion channel activity; IMP:UniProtKB.
# GO_process	GO:0098656	anion transmembrane transport; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.80.10.10	-; 2.
# Genevisible	Q7L1W4	HS
# HGNC	HGNC:16992	LRRC8D
# InterPro	IPR001611	Leu-rich_rpt
# InterPro	IPR003591	Leu-rich_rpt_typical-subtyp
# InterPro	IPR021040	LRRC8_Pannexin-like
# InterPro	IPR032675	L_dom-like
# KEGG_Disease	H00085	[Primary immunodeficiency] Leucine-rich repeat-containing 8
# MIM	612890	gene
# Organism	LRC8D_HUMAN	Homo sapiens (Human)
# PROSITE	PS51450	LRR; 9
# Pfam	PF12534	Pannexin_like
# Pfam	PF13855	LRR_8; 2
# Proteomes	UP000005640	Chromosome 1
# RecName	LRC8D_HUMAN	Volume-regulated anion channel subunit LRRC8D
# RefSeq	NP_001127951	NM_001134479.1
# RefSeq	NP_060573	NM_018103.4
# RefSeq	XP_011539991	XM_011541689.1
# RefSeq	XP_016857088	XM_017001599.1
# RefSeq	XP_016857089	XM_017001600.1
# RefSeq	XP_016857090	XM_017001601.1
# RefSeq	XP_016857091	XM_017001602.1
# SEQUENCE CAUTION	Sequence=AAQ89233.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91631.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the LRRC8 family. {ECO	0000305}. 
# SIMILARITY	Contains 13 LRR (leucine-rich) repeats. {ECO	0000305}. 
# SMART	SM00369	LRR_TYP; 7
# SUBCELLULAR LOCATION	LRC8D_HUMAN	Cell membrane {ECO 0000269|PubMed 24782309, ECO 0000269|PubMed 24790029}; Multi-pass membrane protein {ECO 0000305}. Endoplasmic reticulum membrane {ECO 0000269|PubMed 24782309, ECO 0000305|PubMed 24790029}. Note=In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum (PubMed 24782309, PubMed 24790029). Requires LRRC8A for expression at the cell membrane (PubMed 24790029). {ECO 0000269|PubMed 24782309, ECO 0000269|PubMed 24790029}. 
# SUBUNIT	LRC8D_HUMAN	Heterooligomer; heterooligomerizes with other LRRC8 proteins (LRRC8A, LRRC8B, LRRC8C and/or LRRC8E), possibly to form a heterohexamer (PubMed 24790029, PubMed 26824658). In vivo, the subunit composition may depend primarily on expression levels, and heterooligomeric channels containing various proportions of the different LRRC8 proteins may coexist (Probable). {ECO 0000269|PubMed 24790029, ECO 0000269|PubMed 26824658, ECO 0000305}. 
# SUPFAM	SSF52058	SSF52058
# TCDB	1.A.25.3	the gap junction-forming innexin (innexin) family
# UCSC	uc001dnm	human
# eggNOG	COG4886	LUCA
# eggNOG	KOG0619	Eukaryota
BLAST	swissprot:LRC8D_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:LRC8D_HUMAN
COXPRESdb	55144	http://coxpresdb.jp/data/gene/55144.shtml
CleanEx	HS_LRRC8D	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_LRRC8D
DIP	DIP-31280N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31280N
DOI	10.1002/bies.201100173	http://dx.doi.org/10.1002/bies.201100173
DOI	10.1016/j.cell.2015.12.031	http://dx.doi.org/10.1016/j.cell.2015.12.031
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/jbc.M114.571257	http://dx.doi.org/10.1074/jbc.M114.571257
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1252826	http://dx.doi.org/10.1126/science.1252826
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.15252/embj.201592409	http://dx.doi.org/10.15252/embj.201592409
EMBL	AK001332	http://www.ebi.ac.uk/ena/data/view/AK001332
EMBL	AL391497	http://www.ebi.ac.uk/ena/data/view/AL391497
EMBL	AY358874	http://www.ebi.ac.uk/ena/data/view/AY358874
EMBL	BC024159	http://www.ebi.ac.uk/ena/data/view/BC024159
EMBL	CH471097	http://www.ebi.ac.uk/ena/data/view/CH471097
EMBL	CH471097	http://www.ebi.ac.uk/ena/data/view/CH471097
EMBL	CH471097	http://www.ebi.ac.uk/ena/data/view/CH471097
Ensembl	ENST00000337338	http://www.ensembl.org/id/ENST00000337338
Ensembl	ENST00000394593	http://www.ensembl.org/id/ENST00000394593
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0005225	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005225
GO_process	GO:0098656	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098656
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.80.10.10	http://www.cathdb.info/version/latest/superfamily/3.80.10.10
GeneCards	LRRC8D	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=LRRC8D
GeneID	55144	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55144
GeneTree	ENSGT00840000129676	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00840000129676
HGNC	HGNC:16992	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16992
HOGENOM	HOG000231806	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231806&db=HOGENOM6
HOVERGEN	HBG052360	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052360&db=HOVERGEN
HPA	HPA014745	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014745
InParanoid	Q7L1W4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q7L1W4
IntAct	Q7L1W4	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q7L1W4*
InterPro	IPR001611	http://www.ebi.ac.uk/interpro/entry/IPR001611
InterPro	IPR003591	http://www.ebi.ac.uk/interpro/entry/IPR003591
InterPro	IPR021040	http://www.ebi.ac.uk/interpro/entry/IPR021040
InterPro	IPR032675	http://www.ebi.ac.uk/interpro/entry/IPR032675
Jabion	55144	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55144
KEGG_Disease	H00085	http://www.genome.jp/dbget-bin/www_bget?H00085
KEGG_Gene	hsa:55144	http://www.genome.jp/dbget-bin/www_bget?hsa:55144
MIM	612890	http://www.ncbi.nlm.nih.gov/omim/612890
MINT	MINT-4995188	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4995188
OMA	QLFKCVK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QLFKCVK
OrthoDB	EOG091G01ER	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01ER
PROSITE	PS51450	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51450
PSORT	swissprot:LRC8D_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:LRC8D_HUMAN
PSORT-B	swissprot:LRC8D_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:LRC8D_HUMAN
PSORT2	swissprot:LRC8D_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:LRC8D_HUMAN
Pfam	PF12534	http://pfam.xfam.org/family/PF12534
Pfam	PF13855	http://pfam.xfam.org/family/PF13855
PharmGKB	PA30464	http://www.pharmgkb.org/do/serve?objId=PA30464&objCls=Gene
Phobius	swissprot:LRC8D_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:LRC8D_HUMAN
PhylomeDB	Q7L1W4	http://phylomedb.org/?seqid=Q7L1W4
ProteinModelPortal	Q7L1W4	http://www.proteinmodelportal.org/query/uniprot/Q7L1W4
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	22532330	http://www.ncbi.nlm.nih.gov/pubmed/22532330
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24782309	http://www.ncbi.nlm.nih.gov/pubmed/24782309
PubMed	24790029	http://www.ncbi.nlm.nih.gov/pubmed/24790029
PubMed	26530471	http://www.ncbi.nlm.nih.gov/pubmed/26530471
PubMed	26824658	http://www.ncbi.nlm.nih.gov/pubmed/26824658
RefSeq	NP_001127951	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001127951
RefSeq	NP_060573	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060573
RefSeq	XP_011539991	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011539991
RefSeq	XP_016857088	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016857088
RefSeq	XP_016857089	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016857089
RefSeq	XP_016857090	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016857090
RefSeq	XP_016857091	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016857091
SMART	SM00369	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00369
STRING	9606.ENSP00000338887	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000338887&targetmode=cogs
SUPFAM	SSF52058	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52058
TCDB	1.A.25.3	http://www.tcdb.org/search/result.php?tc=1.A.25.3
UCSC	uc001dnm	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001dnm&org=rat
UniGene	Hs.482087	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.482087
UniProtKB	LRC8D_HUMAN	http://www.uniprot.org/uniprot/LRC8D_HUMAN
UniProtKB-AC	Q7L1W4	http://www.uniprot.org/uniprot/Q7L1W4
charge	swissprot:LRC8D_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:LRC8D_HUMAN
eggNOG	COG4886	http://eggnogapi.embl.de/nog_data/html/tree/COG4886
eggNOG	KOG0619	http://eggnogapi.embl.de/nog_data/html/tree/KOG0619
epestfind	swissprot:LRC8D_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:LRC8D_HUMAN
garnier	swissprot:LRC8D_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:LRC8D_HUMAN
helixturnhelix	swissprot:LRC8D_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:LRC8D_HUMAN
hmoment	swissprot:LRC8D_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:LRC8D_HUMAN
iep	swissprot:LRC8D_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:LRC8D_HUMAN
inforesidue	swissprot:LRC8D_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:LRC8D_HUMAN
neXtProt	NX_Q7L1W4	http://www.nextprot.org/db/entry/NX_Q7L1W4
octanol	swissprot:LRC8D_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:LRC8D_HUMAN
pepcoil	swissprot:LRC8D_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:LRC8D_HUMAN
pepdigest	swissprot:LRC8D_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:LRC8D_HUMAN
pepinfo	swissprot:LRC8D_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:LRC8D_HUMAN
pepnet	swissprot:LRC8D_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:LRC8D_HUMAN
pepstats	swissprot:LRC8D_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:LRC8D_HUMAN
pepwheel	swissprot:LRC8D_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:LRC8D_HUMAN
pepwindow	swissprot:LRC8D_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:LRC8D_HUMAN
sigcleave	swissprot:LRC8D_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:LRC8D_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNS3_HUMAN	Delayed-rectifier K(+) channel alpha subunit 3
# AltName	KCNS3_HUMAN	Voltage-gated potassium channel subunit Kv9.3
# BioGrid	109991	34
# DOMAIN	KCNS3_HUMAN	The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. {ECO 0000250|UniProtKB P63142}. 
# Ensembl	ENST00000304101	ENSP00000305824; ENSG00000170745
# Ensembl	ENST00000403915	ENSP00000385968; ENSG00000170745
# ExpressionAtlas	Q9BQ31	baseline and differential
# FUNCTION	KCNS3_HUMAN	Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed 10484328). Heterotetrameric channel activity formed with KCNB1 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity). {ECO 0000250|UniProtKB O88759, ECO 0000269|PubMed 10484328}. 
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0005794	Golgi apparatus; IDA:HPA.
# GO_component	GO:0005886	plasma membrane; IDA:HPA.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IEA:InterPro.
# GO_component	GO:0016021	integral component of membrane; IBA:GO_Central.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; TAS:ProtInc.
# GO_function	GO:0015459	potassium channel regulator activity; TAS:ProtInc.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0050796	regulation of insulin secretion; TAS:Reactome.
# GO_process	GO:0051260	protein homooligomerization; IEA:InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.20.120.350	-; 1.
# Genevisible	Q9BQ31	HS
# HGNC	HGNC:6302	KCNS3
# InterPro	IPR000210	BTB/POZ_dom
# InterPro	IPR003131	T1-type_BTB
# InterPro	IPR003968	K_chnl_volt-dep_Kv
# InterPro	IPR003971	K_chnl_volt-dep_Kv9
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR011333	SKP1/BTB/POZ
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko04040	Ion channels
# MIM	603888	gene
# Organism	KCNS3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11537	PTHR11537
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01491	KVCHANNEL
# PRINTS	PR01494	KV9CHANNEL
# Pfam	PF00520	Ion_trans
# Pfam	PF02214	BTB_2
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# Reactome	R-HSA-381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
# RecName	KCNS3_HUMAN	Potassium voltage-gated channel subfamily S member 3
# RefSeq	NP_001269357	NM_001282428.1
# RefSeq	NP_002243	NM_002252.4
# RefSeq	XP_011531127	XM_011532825.1
# RefSeq	XP_016859548	XM_017004059.1
# SIMILARITY	Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.3/KCNS3 sub-subfamily. {ECO	0000305}.
# SMART	SM00225	BTB
# SUBCELLULAR LOCATION	KCNS3_HUMAN	Cell membrane {ECO 0000269|PubMed 10484328}; Multi-pass membrane protein {ECO 0000305}. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 (PubMed 10484328). {ECO 0000269|PubMed 10484328}. 
# SUBUNIT	KCNS3_HUMAN	Heterotetramer with KCNB1 (PubMed 10484328). Does not form homomultimers (PubMed 10484328). {ECO 0000269|PubMed 10484328}. 
# SUPFAM	SSF54695	SSF54695
# TCDB	1.A.1.2.15	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	KCNS3_HUMAN	Detected in whole normal term placental and placental chorionic plate arteries and veins. Detected in syncytiotrophoblast and in blood vessel endothelium within intermediate villi and chorionic plate (at protein level) (PubMed 22943705). Detected in most tissues, but not in peripheral blood lymphocytes. The highest levels of expression are in lung (PubMed 10484328). {ECO 0000269|PubMed 10484328, ECO 0000269|PubMed 22943705}. 
# UCSC	uc002rcv	human
# eggNOG	COG1226	LUCA
# eggNOG	KOG3713	Eukaryota
BLAST	swissprot:KCNS3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNS3_HUMAN
BioCyc	ZFISH:ENSG00000170745-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000170745-MONOMER
COXPRESdb	3790	http://coxpresdb.jp/data/gene/3790.shtml
CleanEx	HS_KCNS3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNS3
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.3109/01443615.2012.709288	http://dx.doi.org/10.3109/01443615.2012.709288
EMBL	AC093731	http://www.ebi.ac.uk/ena/data/view/AC093731
EMBL	AF043472	http://www.ebi.ac.uk/ena/data/view/AF043472
EMBL	AK314451	http://www.ebi.ac.uk/ena/data/view/AK314451
EMBL	BC004148	http://www.ebi.ac.uk/ena/data/view/BC004148
EMBL	BC004987	http://www.ebi.ac.uk/ena/data/view/BC004987
EMBL	BC015947	http://www.ebi.ac.uk/ena/data/view/BC015947
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
EMBL	CH471053	http://www.ebi.ac.uk/ena/data/view/CH471053
Ensembl	ENST00000304101	http://www.ensembl.org/id/ENST00000304101
Ensembl	ENST00000403915	http://www.ensembl.org/id/ENST00000403915
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_function	GO:0015459	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015459
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0050796	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050796
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	KCNS3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNS3
GeneID	3790	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3790
GeneTree	ENSGT00760000118981	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118981
H-InvDB	HIX0001848	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0001848
HGNC	HGNC:6302	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6302
HOGENOM	HOG000231016	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231016&db=HOGENOM6
HOVERGEN	HBG052230	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052230&db=HOVERGEN
HPA	HPA014864	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014864
InParanoid	Q9BQ31	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9BQ31
IntAct	Q9BQ31	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9BQ31*
InterPro	IPR000210	http://www.ebi.ac.uk/interpro/entry/IPR000210
InterPro	IPR003131	http://www.ebi.ac.uk/interpro/entry/IPR003131
InterPro	IPR003968	http://www.ebi.ac.uk/interpro/entry/IPR003968
InterPro	IPR003971	http://www.ebi.ac.uk/interpro/entry/IPR003971
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR011333	http://www.ebi.ac.uk/interpro/entry/IPR011333
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	3790	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3790
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3790	http://www.genome.jp/dbget-bin/www_bget?hsa:3790
KEGG_Orthology	KO:K04933	http://www.genome.jp/dbget-bin/www_bget?KO:K04933
MIM	603888	http://www.ncbi.nlm.nih.gov/omim/603888
OMA	FTWVENV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FTWVENV
OrthoDB	EOG091G0FP3	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0FP3
PANTHER	PTHR11537	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01491	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01491
PRINTS	PR01494	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01494
PSORT	swissprot:KCNS3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNS3_HUMAN
PSORT-B	swissprot:KCNS3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNS3_HUMAN
PSORT2	swissprot:KCNS3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNS3_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF02214	http://pfam.xfam.org/family/PF02214
PharmGKB	PA30080	http://www.pharmgkb.org/do/serve?objId=PA30080&objCls=Gene
Phobius	swissprot:KCNS3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNS3_HUMAN
PhylomeDB	Q9BQ31	http://phylomedb.org/?seqid=Q9BQ31
ProteinModelPortal	Q9BQ31	http://www.proteinmodelportal.org/query/uniprot/Q9BQ31
PubMed	10484328	http://www.ncbi.nlm.nih.gov/pubmed/10484328
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	22943705	http://www.ncbi.nlm.nih.gov/pubmed/22943705
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
Reactome	R-HSA-381676	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-381676
RefSeq	NP_001269357	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269357
RefSeq	NP_002243	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002243
RefSeq	XP_011531127	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011531127
RefSeq	XP_016859548	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016859548
SMART	SM00225	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225
SMR	Q9BQ31	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9BQ31
STRING	9606.ENSP00000305824	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000305824&targetmode=cogs
SUPFAM	SSF54695	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54695
TCDB	1.A.1.2.15	http://www.tcdb.org/search/result.php?tc=1.A.1.2.15
UCSC	uc002rcv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002rcv&org=rat
UniGene	Hs.414489	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.414489
UniProtKB	KCNS3_HUMAN	http://www.uniprot.org/uniprot/KCNS3_HUMAN
UniProtKB-AC	Q9BQ31	http://www.uniprot.org/uniprot/Q9BQ31
charge	swissprot:KCNS3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNS3_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG3713	http://eggnogapi.embl.de/nog_data/html/tree/KOG3713
epestfind	swissprot:KCNS3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNS3_HUMAN
garnier	swissprot:KCNS3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNS3_HUMAN
helixturnhelix	swissprot:KCNS3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNS3_HUMAN
hmoment	swissprot:KCNS3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNS3_HUMAN
iep	swissprot:KCNS3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNS3_HUMAN
inforesidue	swissprot:KCNS3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNS3_HUMAN
neXtProt	NX_Q9BQ31	http://www.nextprot.org/db/entry/NX_Q9BQ31
octanol	swissprot:KCNS3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNS3_HUMAN
pepcoil	swissprot:KCNS3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNS3_HUMAN
pepdigest	swissprot:KCNS3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNS3_HUMAN
pepinfo	swissprot:KCNS3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNS3_HUMAN
pepnet	swissprot:KCNS3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNS3_HUMAN
pepstats	swissprot:KCNS3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNS3_HUMAN
pepwheel	swissprot:KCNS3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNS3_HUMAN
pepwindow	swissprot:KCNS3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNS3_HUMAN
sigcleave	swissprot:KCNS3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNS3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	VDAC3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y277-1; Sequence=Displayed; Name=2; IsoId=Q9Y277-2; Sequence=VSP_005079; 
# AltName	VDAC3_HUMAN	Outer mitochondrial membrane protein porin 3
# BioGrid	113262	109
# CCDS	CCDS47850	-. [Q9Y277-2]
# CCDS	CCDS6131	-. [Q9Y277-1]
# ChiTaRS	VDAC3	human
# DOMAIN	VDAC3_HUMAN	Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. {ECO 0000250}. 
# DrugBank	DB01375	Dihydroxyaluminium
# Ensembl	ENST00000022615	ENSP00000022615; ENSG00000078668. [Q9Y277-1]
# Ensembl	ENST00000521158	ENSP00000428845; ENSG00000078668. [Q9Y277-2]
# ExpressionAtlas	Q9Y277	baseline and differential
# FUNCTION	VDAC3_HUMAN	Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. {ECO 0000250}. 
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005741	mitochondrial outer membrane; TAS:ProtInc.
# GO_component	GO:0046930	pore complex; IEA:UniProtKB-KW.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0000166	nucleotide binding; IEA:UniProtKB-KW.
# GO_function	GO:0008308	voltage-gated anion channel activity; TAS:UniProtKB.
# GO_function	GO:0015288	porin activity; IEA:UniProtKB-KW.
# GO_process	GO:0015853	adenine transport; TAS:ProtInc.
# GO_process	GO:1902017	regulation of cilium assembly; IEA:InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Gene3D	2.40.160.10	-; 1.
# Genevisible	Q9Y277	HS
# HGNC	HGNC:12674	VDAC3
# IntAct	Q9Y277	16
# InterPro	IPR001925	Porin_Euk
# InterPro	IPR023614	Porin_dom
# InterPro	IPR027246	Porin_Euk/Tom40
# InterPro	IPR030271	VDAC3
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# KEGG_Pathway	ko05161	Hepatitis B
# KEGG_Pathway	ko05166	HTLV-I infection
# KEGG_Pathway	ko05203	Viral carcinogenesis
# MIM	610029	gene
# Organism	VDAC3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11743:SF28	PTHR11743:SF28
# PRINTS	PR00185	EUKARYTPORIN
# PROSITE	PS00558	EUKARYOTIC_PORIN
# PTM	VDAC3_HUMAN	Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. {ECO 0000269|PubMed 25621951}. 
# Pfam	PF01459	Porin_3
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-5689880	Ub-specific processing proteases
# RecName	VDAC3_HUMAN	Voltage-dependent anion-selective channel protein 3
# RefSeq	NP_001129166	NM_001135694.2. [Q9Y277-2]
# RefSeq	NP_005653	NM_005662.6. [Q9Y277-1]
# SIMILARITY	Belongs to the eukaryotic mitochondrial porin family. {ECO	0000305}.
# SUBCELLULAR LOCATION	VDAC3_HUMAN	Mitochondrion outer membrane. 
# TISSUE SPECIFICITY	VDAC3_HUMAN	Widely expressed. Highest in testis. 
# UCSC	uc003xpc	human. [Q9Y277-1]
# eggNOG	ENOG410ZBK1	LUCA
# eggNOG	KOG3126	Eukaryota
BLAST	swissprot:VDAC3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VDAC3_HUMAN
BioCyc	ZFISH:ENSG00000078668-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000078668-MONOMER
COXPRESdb	7419	http://coxpresdb.jp/data/gene/7419.shtml
CleanEx	HS_VDAC3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_VDAC3
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/mgme.2000.2987	http://dx.doi.org/10.1006/mgme.2000.2987
DOI	10.1007/s003359901158	http://dx.doi.org/10.1007/s003359901158
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/ncb3097	http://dx.doi.org/10.1038/ncb3097
DOI	10.1038/sj.ejhg.5200198	http://dx.doi.org/10.1038/sj.ejhg.5200198
DOI	10.1073/pnas.95.14.8175	http://dx.doi.org/10.1073/pnas.95.14.8175
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DrugBank	DB01375	http://www.drugbank.ca/drugs/DB01375
EMBL	AF038962	http://www.ebi.ac.uk/ena/data/view/AF038962
EMBL	AH008073	http://www.ebi.ac.uk/ena/data/view/AH008073
EMBL	BC056870	http://www.ebi.ac.uk/ena/data/view/BC056870
EMBL	U90943	http://www.ebi.ac.uk/ena/data/view/U90943
Ensembl	ENST00000022615	http://www.ensembl.org/id/ENST00000022615
Ensembl	ENST00000521158	http://www.ensembl.org/id/ENST00000521158
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005741	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005741
GO_component	GO:0046930	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046930
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0000166	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166
GO_function	GO:0008308	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008308
GO_function	GO:0015288	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015288
GO_process	GO:0015853	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015853
GO_process	GO:1902017	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902017
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	2.40.160.10	http://www.cathdb.info/version/latest/superfamily/2.40.160.10
GeneCards	VDAC3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=VDAC3
GeneID	7419	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7419
GeneTree	ENSGT00390000011336	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000011336
HGNC	HGNC:12674	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:12674
HOGENOM	HOG000188277	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000188277&db=HOGENOM6
HOVERGEN	HBG054036	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054036&db=HOVERGEN
HPA	HPA026864	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA026864
InParanoid	Q9Y277	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y277
IntAct	Q9Y277	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9Y277*
InterPro	IPR001925	http://www.ebi.ac.uk/interpro/entry/IPR001925
InterPro	IPR023614	http://www.ebi.ac.uk/interpro/entry/IPR023614
InterPro	IPR027246	http://www.ebi.ac.uk/interpro/entry/IPR027246
InterPro	IPR030271	http://www.ebi.ac.uk/interpro/entry/IPR030271
Jabion	7419	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7419
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:7419	http://www.genome.jp/dbget-bin/www_bget?hsa:7419
KEGG_Orthology	KO:K15041	http://www.genome.jp/dbget-bin/www_bget?KO:K15041
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
KEGG_Pathway	ko05161	http://www.genome.jp/kegg-bin/show_pathway?ko05161
KEGG_Pathway	ko05166	http://www.genome.jp/kegg-bin/show_pathway?ko05166
KEGG_Pathway	ko05203	http://www.genome.jp/kegg-bin/show_pathway?ko05203
MIM	610029	http://www.ncbi.nlm.nih.gov/omim/610029
MINT	MINT-1395020	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1395020
OMA	ICNYGLT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ICNYGLT
OrthoDB	EOG091G0F0O	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0F0O
PANTHER	PTHR11743:SF28	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11743:SF28
PRINTS	PR00185	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00185
PROSITE	PS00558	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00558
PSORT	swissprot:VDAC3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VDAC3_HUMAN
PSORT-B	swissprot:VDAC3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VDAC3_HUMAN
PSORT2	swissprot:VDAC3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VDAC3_HUMAN
Pfam	PF01459	http://pfam.xfam.org/family/PF01459
PharmGKB	PA37297	http://www.pharmgkb.org/do/serve?objId=PA37297&objCls=Gene
Phobius	swissprot:VDAC3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VDAC3_HUMAN
PhylomeDB	Q9Y277	http://phylomedb.org/?seqid=Q9Y277
ProteinModelPortal	Q9Y277	http://www.proteinmodelportal.org/query/uniprot/Q9Y277
PubMed	10501981	http://www.ncbi.nlm.nih.gov/pubmed/10501981
PubMed	10833333	http://www.ncbi.nlm.nih.gov/pubmed/10833333
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	25621951	http://www.ncbi.nlm.nih.gov/pubmed/25621951
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	9653160	http://www.ncbi.nlm.nih.gov/pubmed/9653160
PubMed	9781040	http://www.ncbi.nlm.nih.gov/pubmed/9781040
Reactome	R-HSA-5689880	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5689880
RefSeq	NP_001129166	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001129166
RefSeq	NP_005653	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005653
SMR	Q9Y277	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9Y277
STRING	9606.ENSP00000428845	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000428845&targetmode=cogs
UCSC	uc003xpc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003xpc&org=rat
UniGene	Hs.699301	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.699301
UniProtKB	VDAC3_HUMAN	http://www.uniprot.org/uniprot/VDAC3_HUMAN
UniProtKB-AC	Q9Y277	http://www.uniprot.org/uniprot/Q9Y277
charge	swissprot:VDAC3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VDAC3_HUMAN
eggNOG	ENOG410ZBK1	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZBK1
eggNOG	KOG3126	http://eggnogapi.embl.de/nog_data/html/tree/KOG3126
epestfind	swissprot:VDAC3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VDAC3_HUMAN
garnier	swissprot:VDAC3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VDAC3_HUMAN
helixturnhelix	swissprot:VDAC3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VDAC3_HUMAN
hmoment	swissprot:VDAC3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VDAC3_HUMAN
iep	swissprot:VDAC3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VDAC3_HUMAN
inforesidue	swissprot:VDAC3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VDAC3_HUMAN
neXtProt	NX_Q9Y277	http://www.nextprot.org/db/entry/NX_Q9Y277
octanol	swissprot:VDAC3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VDAC3_HUMAN
pepcoil	swissprot:VDAC3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VDAC3_HUMAN
pepdigest	swissprot:VDAC3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VDAC3_HUMAN
pepinfo	swissprot:VDAC3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VDAC3_HUMAN
pepnet	swissprot:VDAC3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VDAC3_HUMAN
pepstats	swissprot:VDAC3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VDAC3_HUMAN
pepwheel	swissprot:VDAC3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VDAC3_HUMAN
pepwindow	swissprot:VDAC3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VDAC3_HUMAN
sigcleave	swissprot:VDAC3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VDAC3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TPC10_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P48553-1; Sequence=Displayed; Name=2; IsoId=P48553-2; Sequence=VSP_056589, VSP_056590; Note=No experimental confirmation available.; 
# AltName	TPC10_HUMAN	Epilepsy holoprosencephaly candidate 1 protein
# AltName	TPC10_HUMAN	Protein GT334
# AltName	TPC10_HUMAN	Trafficking protein particle complex subunit TMEM1
# AltName	TPC10_HUMAN	Transport protein particle subunit TMEM1
# BioGrid	112964	31
# CCDS	CCDS13704	-. [P48553-1]
# ChiTaRS	TRAPPC10	human
# Ensembl	ENST00000291574	ENSP00000291574; ENSG00000160218. [P48553-1]
# Ensembl	ENST00000380221	ENSP00000369570; ENSG00000160218. [P48553-2]
# ExpressionAtlas	P48553	baseline and differential
# FUNCTION	TPC10_HUMAN	May play a role in vesicular transport from endoplasmic reticulum to Golgi. 
# GO_component	GO:0000139	Golgi membrane; IEA:GOC.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_component	GO:1990071	TRAPPII protein complex; IBA:GO_Central.
# GO_function	GO:0015081	sodium ion transmembrane transporter activity; TAS:ProtInc.
# GO_process	GO:0006814	sodium ion transport; TAS:ProtInc.
# GO_process	GO:0006891	intra-Golgi vesicle-mediated transport; IBA:GO_Central.
# GO_process	GO:0034498	early endosome to Golgi transport; IBA:GO_Central.
# GO_process	GO:0048208	COPII vesicle coating; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0016192	vesicle-mediated transport
# Genevisible	P48553	HS
# HGNC	HGNC:11868	TRAPPC10
# INTERACTION	TPC10_HUMAN	Q96QF0 RAB3IP; NbExp=7; IntAct=EBI-6160572, EBI-747844; 
# IntAct	P48553	2
# InterPro	IPR022233	TRAPP_II_complex_TRAPPC10
# MIM	602103	gene
# Organism	TPC10_HUMAN	Homo sapiens (Human)
# PIR	JC5523	JC5523
# Pfam	PF12584	TRAPPC10
# Proteomes	UP000005640	Chromosome 21
# Reactome	R-HSA-204005	COPII (Coat Protein 2) Mediated Vesicle Transport
# Reactome	R-HSA-8876198	RAB GEFs exchange GTP for GDP on RABs
# RecName	TPC10_HUMAN	Trafficking protein particle complex subunit 10
# RefSeq	NP_003265	NM_003274.4. [P48553-1]
# RefSeq	XP_016855323	XM_016999834.1. [P48553-1]
# SEQUENCE CAUTION	Sequence=AAC50134.1; Type=Frameshift; Positions=1187; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the TMEM1 family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	TPC10_HUMAN	Golgi apparatus, cis-Golgi network {ECO 0000250}. 
# SUBUNIT	TPC10_HUMAN	Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. {ECO 0000269|PubMed 11805826, ECO 0000269|PubMed 21525244}. 
# TISSUE SPECIFICITY	TPC10_HUMAN	Expressed in all tissues examined. 
# UCSC	uc002zdz	human. [P48553-1]
# eggNOG	ENOG410XNVF	LUCA
# eggNOG	KOG1931	Eukaryota
BLAST	swissprot:TPC10_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TPC10_HUMAN
BioCyc	ZFISH:ENSG00000160218-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000160218-MONOMER
COXPRESdb	7109	http://coxpresdb.jp/data/gene/7109.shtml
CleanEx	HS_TRAPPC10	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TRAPPC10
DIP	DIP-48281N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48281N
DOI	10.1006/bbrc.1997.6758	http://dx.doi.org/10.1006/bbrc.1997.6758
DOI	10.1016/S0378-1119(97)00333-8	http://dx.doi.org/10.1016/S0378-1119(97)00333-8
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/35012518	http://dx.doi.org/10.1038/35012518
DOI	10.1038/415141a	http://dx.doi.org/10.1038/415141a
DOI	10.1091/mbc.E10-11-0873	http://dx.doi.org/10.1091/mbc.E10-11-0873
DOI	10.1093/hmg/4.4.709	http://dx.doi.org/10.1093/hmg/4.4.709
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
EMBL	AB001517	http://www.ebi.ac.uk/ena/data/view/AB001517
EMBL	AB001523	http://www.ebi.ac.uk/ena/data/view/AB001523
EMBL	BC046241	http://www.ebi.ac.uk/ena/data/view/BC046241
EMBL	BC052247	http://www.ebi.ac.uk/ena/data/view/BC052247
EMBL	BC094823	http://www.ebi.ac.uk/ena/data/view/BC094823
EMBL	BC101728	http://www.ebi.ac.uk/ena/data/view/BC101728
EMBL	U19252	http://www.ebi.ac.uk/ena/data/view/U19252
EMBL	U61500	http://www.ebi.ac.uk/ena/data/view/U61500
EMBL	U61501	http://www.ebi.ac.uk/ena/data/view/U61501
EMBL	U61502	http://www.ebi.ac.uk/ena/data/view/U61502
EMBL	U61503	http://www.ebi.ac.uk/ena/data/view/U61503
EMBL	U61504	http://www.ebi.ac.uk/ena/data/view/U61504
EMBL	U61505	http://www.ebi.ac.uk/ena/data/view/U61505
EMBL	U61506	http://www.ebi.ac.uk/ena/data/view/U61506
EMBL	U61507	http://www.ebi.ac.uk/ena/data/view/U61507
EMBL	U61508	http://www.ebi.ac.uk/ena/data/view/U61508
EMBL	U61509	http://www.ebi.ac.uk/ena/data/view/U61509
EMBL	U61510	http://www.ebi.ac.uk/ena/data/view/U61510
EMBL	U61511	http://www.ebi.ac.uk/ena/data/view/U61511
EMBL	U61512	http://www.ebi.ac.uk/ena/data/view/U61512
EMBL	U61513	http://www.ebi.ac.uk/ena/data/view/U61513
EMBL	U61514	http://www.ebi.ac.uk/ena/data/view/U61514
EMBL	U61515	http://www.ebi.ac.uk/ena/data/view/U61515
EMBL	U61516	http://www.ebi.ac.uk/ena/data/view/U61516
EMBL	U61517	http://www.ebi.ac.uk/ena/data/view/U61517
EMBL	U61518	http://www.ebi.ac.uk/ena/data/view/U61518
EMBL	U61519	http://www.ebi.ac.uk/ena/data/view/U61519
EMBL	U61520	http://www.ebi.ac.uk/ena/data/view/U61520
Ensembl	ENST00000291574	http://www.ensembl.org/id/ENST00000291574
Ensembl	ENST00000380221	http://www.ensembl.org/id/ENST00000380221
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:1990071	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990071
GO_function	GO:0015081	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015081
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0006891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006891
GO_process	GO:0034498	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034498
GO_process	GO:0048208	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048208
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GeneCards	TRAPPC10	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TRAPPC10
GeneID	7109	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7109
GeneTree	ENSGT00390000003873	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000003873
HGNC	HGNC:11868	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11868
HOGENOM	HOG000046007	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000046007&db=HOGENOM6
HOVERGEN	HBG108593	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108593&db=HOVERGEN
HPA	HPA050423	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA050423
InParanoid	P48553	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P48553
IntAct	P48553	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P48553*
InterPro	IPR022233	http://www.ebi.ac.uk/interpro/entry/IPR022233
Jabion	7109	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7109
KEGG_Gene	hsa:7109	http://www.genome.jp/dbget-bin/www_bget?hsa:7109
MIM	602103	http://www.ncbi.nlm.nih.gov/omim/602103
OMA	ALDCWVF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ALDCWVF
OrthoDB	EOG091G02NV	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02NV
PSORT	swissprot:TPC10_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TPC10_HUMAN
PSORT-B	swissprot:TPC10_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TPC10_HUMAN
PSORT2	swissprot:TPC10_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TPC10_HUMAN
Pfam	PF12584	http://pfam.xfam.org/family/PF12584
PharmGKB	PA162406870	http://www.pharmgkb.org/do/serve?objId=PA162406870&objCls=Gene
Phobius	swissprot:TPC10_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TPC10_HUMAN
PhylomeDB	P48553	http://phylomedb.org/?seqid=P48553
ProteinModelPortal	P48553	http://www.proteinmodelportal.org/query/uniprot/P48553
PubMed	10830953	http://www.ncbi.nlm.nih.gov/pubmed/10830953
PubMed	11805826	http://www.ncbi.nlm.nih.gov/pubmed/11805826
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21525244	http://www.ncbi.nlm.nih.gov/pubmed/21525244
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	7633421	http://www.ncbi.nlm.nih.gov/pubmed/7633421
PubMed	9196060	http://www.ncbi.nlm.nih.gov/pubmed/9196060
PubMed	9370297	http://www.ncbi.nlm.nih.gov/pubmed/9370297
Reactome	R-HSA-204005	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-204005
Reactome	R-HSA-8876198	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8876198
RefSeq	NP_003265	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003265
RefSeq	XP_016855323	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016855323
SMR	P48553	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P48553
STRING	9606.ENSP00000291574	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000291574&targetmode=cogs
UCSC	uc002zdz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002zdz&org=rat
UniGene	Hs.126221	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.126221
UniProtKB	TPC10_HUMAN	http://www.uniprot.org/uniprot/TPC10_HUMAN
UniProtKB-AC	P48553	http://www.uniprot.org/uniprot/P48553
charge	swissprot:TPC10_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TPC10_HUMAN
eggNOG	ENOG410XNVF	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNVF
eggNOG	KOG1931	http://eggnogapi.embl.de/nog_data/html/tree/KOG1931
epestfind	swissprot:TPC10_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TPC10_HUMAN
garnier	swissprot:TPC10_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TPC10_HUMAN
helixturnhelix	swissprot:TPC10_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TPC10_HUMAN
hmoment	swissprot:TPC10_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TPC10_HUMAN
iep	swissprot:TPC10_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TPC10_HUMAN
inforesidue	swissprot:TPC10_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TPC10_HUMAN
neXtProt	NX_P48553	http://www.nextprot.org/db/entry/NX_P48553
octanol	swissprot:TPC10_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TPC10_HUMAN
pepcoil	swissprot:TPC10_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TPC10_HUMAN
pepdigest	swissprot:TPC10_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TPC10_HUMAN
pepinfo	swissprot:TPC10_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TPC10_HUMAN
pepnet	swissprot:TPC10_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TPC10_HUMAN
pepstats	swissprot:TPC10_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TPC10_HUMAN
pepwheel	swissprot:TPC10_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TPC10_HUMAN
pepwindow	swissprot:TPC10_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TPC10_HUMAN
sigcleave	swissprot:TPC10_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TPC10_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TRPC4_HUMAN	Event=Alternative splicing; Named isoforms=7; Name=Alpha; IsoId=Q9UBN4-1; Sequence=Displayed; Name=Beta; IsoId=Q9UBN4-2; Sequence=VSP_006569; Name=Delta; IsoId=Q9UBN4-3; Sequence=VSP_006568; Name=Gamma; IsoId=Q9UBN4-4; Sequence=VSP_006567, VSP_006569; Name=Epsilon; IsoId=Q9UBN4-5; Sequence=VSP_041262; Name=Zeta; IsoId=Q9UBN4-6; Sequence=VSP_041439; Name=Eta; IsoId=Q9UBN4-7; Sequence=VSP_047747, VSP_047748; 
# AltName	TRPC4_HUMAN	Trp-related protein 4
# BioGrid	113074	12
# CCDS	CCDS45035	-. [Q9UBN4-6]
# CCDS	CCDS45036	-. [Q9UBN4-4]
# CCDS	CCDS45037	-. [Q9UBN4-5]
# CCDS	CCDS45038	-. [Q9UBN4-2]
# CCDS	CCDS45039	-. [Q9UBN4-3]
# CCDS	CCDS9365	-. [Q9UBN4-1]
# ChiTaRS	TRPC4	human
# DOMAIN	TRPC4_HUMAN	The calmodulin- and inositol 1,4,5-trisphosphate receptor- binding (CIRB) domain (695-724) is sufficient for the interaction with SESTD1. 
# DOMAIN	TRPC4_HUMAN	The protein 4.1-binding domain (654-685) is required for binding to EPB41L2 and channel activation. 
# DOMAIN	TRPC4_HUMAN	The spectrin-binding domain (730-758) is required for binding to SPTAN1 and SPTBN5. 
# Ensembl	ENST00000338947	ENSP00000342580; ENSG00000133107. [Q9UBN4-6]
# Ensembl	ENST00000355779	ENSP00000348025; ENSG00000133107. [Q9UBN4-3]
# Ensembl	ENST00000358477	ENSP00000351264; ENSG00000133107. [Q9UBN4-2]
# Ensembl	ENST00000379673	ENSP00000368995; ENSG00000133107. [Q9UBN4-4]
# Ensembl	ENST00000379679	ENSP00000369001; ENSG00000133107. [Q9UBN4-6]
# Ensembl	ENST00000379705	ENSP00000369027; ENSG00000133107. [Q9UBN4-1]
# Ensembl	ENST00000488717	ENSP00000435969; ENSG00000133107. [Q9UBN4-7]
# Ensembl	ENST00000625583	ENSP00000486109; ENSG00000133107. [Q9UBN4-5]
# ExpressionAtlas	Q9UBN4	baseline and differential
# FUNCTION	TRPC4_HUMAN	Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion. {ECO 0000269|PubMed 16144838, ECO 0000269|PubMed 19996314}. 
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0005901	caveola; IEA:Ensembl.
# GO_component	GO:0009986	cell surface; IDA:BHF-UCL.
# GO_component	GO:0016323	basolateral plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0030863	cortical cytoskeleton; IDA:UniProtKB.
# GO_component	GO:0034704	calcium channel complex; IDA:UniProtKB.
# GO_component	GO:0043234	protein complex; IEA:Ensembl.
# GO_function	GO:0005262	calcium channel activity; TAS:Reactome.
# GO_function	GO:0008013	beta-catenin binding; IPI:BHF-UCL.
# GO_function	GO:0015279	store-operated calcium channel activity; IMP:UniProtKB.
# GO_function	GO:0045296	cadherin binding; IPI:BHF-UCL.
# GO_function	GO:0070679	inositol 1,4,5 trisphosphate binding; IEA:Ensembl.
# GO_process	GO:0006816	calcium ion transport; TAS:ProtInc.
# GO_process	GO:0006828	manganese ion transport; IBA:GO_Central.
# GO_process	GO:0014051	gamma-aminobutyric acid secretion; IEA:Ensembl.
# GO_process	GO:0048709	oligodendrocyte differentiation; IEA:Ensembl.
# GO_process	GO:0051480	regulation of cytosolic calcium ion concentration; IBA:GO_Central.
# GO_process	GO:0070509	calcium ion import; IDA:BHF-UCL.
# GO_process	GO:0070588	calcium ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005856	cytoskeleton
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.25.40.20	-; 1.
# Genevisible	Q9UBN4	HS
# HGNC	HGNC:12336	TRPC4
# INTERACTION	TRPC4_HUMAN	P20591 MX1; NbExp=2; IntAct=EBI-929504, EBI-929476; 
# IntAct	Q9UBN4	2
# InterPro	IPR002110	Ankyrin_rpt
# InterPro	IPR002153	TRPC_channel
# InterPro	IPR004729	TRP_channel
# InterPro	IPR005460	TRPC4_channel
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR013555	TRP_dom
# InterPro	IPR020683	Ankyrin_rpt-contain_dom
# KEGG_Brite	ko04040	Ion channels
# MIM	603651	gene
# MISCELLANEOUS	TRPC4_HUMAN	The cell membrane presentation, the calcium entry function and the interaction with junctional proteins (CTNNB1 and CDH5) are controlled by endothelial cell-cell contacts. 
# MISCELLANEOUS	TRPC4_HUMAN	The interaction with spectrin is important in controlling the translocation of TRPC4 channels to the plasma membrane following EGF stimulation. 
# Organism	TRPC4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10117	PTHR10117
# PANTHER	PTHR10117:SF25	PTHR10117:SF25
# PRINTS	PR01097	TRNSRECEPTRP
# PRINTS	PR01645	TRPCHANNEL4
# PROSITE	PS50088	ANK_REPEAT
# PROSITE	PS50297	ANK_REP_REGION
# PTM	TRPC4_HUMAN	Phosphorylation modulates TRPC channel function by regulating the level of TRPC4 at the cell surface and by increasing the association with SLC9A3R1/NHERF. {ECO 0000269|PubMed 16144838}. 
# Pfam	PF00520	Ion_trans
# Pfam	PF08344	TRP_2
# Proteomes	UP000005640	Chromosome 13
# Reactome	R-HSA-3295583	TRP channels
# Reactome	R-HSA-418890	Role of second messengers in netrin-1 signaling
# RecName	TRPC4_HUMAN	Short transient receptor potential channel 4
# RefSeq	NP_001129427	NM_001135955.1. [Q9UBN4-2]
# RefSeq	NP_001129428	NM_001135956.1. [Q9UBN4-4]
# RefSeq	NP_001129429	NM_001135957.1. [Q9UBN4-3]
# RefSeq	NP_001129430	NM_001135958.1. [Q9UBN4-6]
# RefSeq	NP_003297	NM_003306.1. [Q9UBN4-5]
# RefSeq	NP_057263	NM_016179.2. [Q9UBN4-1]
# SIMILARITY	Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 4 ANK repeats. {ECO:0000255|PROSITE- ProRule	PRU00023}.
# SMART	SM00248	ANK; 2
# SUBCELLULAR LOCATION	TRPC4_HUMAN	Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Enhanced insertion into the cell membrane after activation of the EGF receptor. 
# SUBUNIT	TRPC4_HUMAN	Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC1 and/or TRPC5. Isoform alpha but not isoform beta associates with inositol 1,4,5-trisphosphate receptor (ITPR). Interacts with (via PDZ-binding domain) with SLC9A3R1/NHERF. Interacts with MX1 and RNF24. Interacts (via CIRB domain) with SESTD1 (via spectrin 1 repeat). Interacts with CDH5 and CTNNB1. Interacts with SPTAN1 (via C-terminal spectrin repeats) and SPTBN5 (via C-terminus). Interacts (via protein 4.1- binding domain) with EPB41L2. {ECO 0000250, ECO 0000269|PubMed 12032305, ECO 0000269|PubMed 12154080, ECO 0000269|PubMed 15757897, ECO 0000269|PubMed 16254212, ECO 0000269|PubMed 17850865, ECO 0000269|PubMed 18048348, ECO 0000269|PubMed 19996314, ECO 0000269|PubMed 20164195}. 
# SUPFAM	SSF48403	SSF48403
# TCDB	1.A.4.1.12	the transient receptor potential ca(2+) channel (trp-cc) family
# TIGRFAMs	TIGR00870	trp
# TISSUE SPECIFICITY	Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Expressed in endothelial cells. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain. {ECO:0000269|PubMed	19996314}. 
# UCSC	uc001uws	human. [Q9UBN4-1]
# eggNOG	ENOG410XQ0Y	LUCA
# eggNOG	KOG3609	Eukaryota
BLAST	swissprot:TRPC4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TRPC4_HUMAN
BioCyc	ZFISH:ENSG00000133107-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000133107-MONOMER
COXPRESdb	7223	http://coxpresdb.jp/data/gene/7223.shtml
CleanEx	HS_TRPC4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TRPC4
DOI	10.1016/S0014-5793(00)02362-0	http://dx.doi.org/10.1016/S0014-5793(00)02362-0
DOI	10.1016/S0092-8674(00)81233-7	http://dx.doi.org/10.1016/S0092-8674(00)81233-7
DOI	10.1016/j.ceca.2007.07.009	http://dx.doi.org/10.1016/j.ceca.2007.07.009
DOI	10.1038/nature02379	http://dx.doi.org/10.1038/nature02379
DOI	10.1042/bj3510735	http://dx.doi.org/10.1042/bj3510735
DOI	10.1073/pnas.102596199	http://dx.doi.org/10.1073/pnas.102596199
DOI	10.1074/jbc.M109.060301	http://dx.doi.org/10.1074/jbc.M109.060301
DOI	10.1074/jbc.M109.068304	http://dx.doi.org/10.1074/jbc.M109.068304
DOI	10.1074/jbc.M109850200	http://dx.doi.org/10.1074/jbc.M109850200
DOI	10.1074/jbc.M500391200	http://dx.doi.org/10.1074/jbc.M500391200
DOI	10.1074/jbc.M503646200	http://dx.doi.org/10.1074/jbc.M503646200
DOI	10.1074/jbc.M709729200	http://dx.doi.org/10.1074/jbc.M709729200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1161/01.RES.0000193597.65217.00	http://dx.doi.org/10.1161/01.RES.0000193597.65217.00
EMBL	AF063822	http://www.ebi.ac.uk/ena/data/view/AF063822
EMBL	AF063823	http://www.ebi.ac.uk/ena/data/view/AF063823
EMBL	AF063824	http://www.ebi.ac.uk/ena/data/view/AF063824
EMBL	AF063825	http://www.ebi.ac.uk/ena/data/view/AF063825
EMBL	AF175406	http://www.ebi.ac.uk/ena/data/view/AF175406
EMBL	AF421358	http://www.ebi.ac.uk/ena/data/view/AF421358
EMBL	AF421359	http://www.ebi.ac.uk/ena/data/view/AF421359
EMBL	AF421360	http://www.ebi.ac.uk/ena/data/view/AF421360
EMBL	AF421361	http://www.ebi.ac.uk/ena/data/view/AF421361
EMBL	AF421362	http://www.ebi.ac.uk/ena/data/view/AF421362
EMBL	AL138679	http://www.ebi.ac.uk/ena/data/view/AL138679
EMBL	AL138679	http://www.ebi.ac.uk/ena/data/view/AL138679
EMBL	AL138679	http://www.ebi.ac.uk/ena/data/view/AL138679
EMBL	AL138679	http://www.ebi.ac.uk/ena/data/view/AL138679
EMBL	AL138679	http://www.ebi.ac.uk/ena/data/view/AL138679
EMBL	AL138679	http://www.ebi.ac.uk/ena/data/view/AL138679
EMBL	AL138679	http://www.ebi.ac.uk/ena/data/view/AL138679
EMBL	AL138679	http://www.ebi.ac.uk/ena/data/view/AL138679
EMBL	AL138679	http://www.ebi.ac.uk/ena/data/view/AL138679
EMBL	AL138679	http://www.ebi.ac.uk/ena/data/view/AL138679
EMBL	AL354802	http://www.ebi.ac.uk/ena/data/view/AL354802
EMBL	AL354802	http://www.ebi.ac.uk/ena/data/view/AL354802
EMBL	AL354802	http://www.ebi.ac.uk/ena/data/view/AL354802
EMBL	AL354802	http://www.ebi.ac.uk/ena/data/view/AL354802
EMBL	AL354802	http://www.ebi.ac.uk/ena/data/view/AL354802
EMBL	AL354802	http://www.ebi.ac.uk/ena/data/view/AL354802
EMBL	AL354802	http://www.ebi.ac.uk/ena/data/view/AL354802
EMBL	AL354802	http://www.ebi.ac.uk/ena/data/view/AL354802
EMBL	AL354802	http://www.ebi.ac.uk/ena/data/view/AL354802
EMBL	AL354802	http://www.ebi.ac.uk/ena/data/view/AL354802
EMBL	BC104725	http://www.ebi.ac.uk/ena/data/view/BC104725
EMBL	CH471075	http://www.ebi.ac.uk/ena/data/view/CH471075
EMBL	CH471075	http://www.ebi.ac.uk/ena/data/view/CH471075
EMBL	CH471075	http://www.ebi.ac.uk/ena/data/view/CH471075
EMBL	CH471075	http://www.ebi.ac.uk/ena/data/view/CH471075
EMBL	CH471075	http://www.ebi.ac.uk/ena/data/view/CH471075
EMBL	CH471075	http://www.ebi.ac.uk/ena/data/view/CH471075
EMBL	U40983	http://www.ebi.ac.uk/ena/data/view/U40983
Ensembl	ENST00000338947	http://www.ensembl.org/id/ENST00000338947
Ensembl	ENST00000355779	http://www.ensembl.org/id/ENST00000355779
Ensembl	ENST00000358477	http://www.ensembl.org/id/ENST00000358477
Ensembl	ENST00000379673	http://www.ensembl.org/id/ENST00000379673
Ensembl	ENST00000379679	http://www.ensembl.org/id/ENST00000379679
Ensembl	ENST00000379705	http://www.ensembl.org/id/ENST00000379705
Ensembl	ENST00000488717	http://www.ensembl.org/id/ENST00000488717
Ensembl	ENST00000625583	http://www.ensembl.org/id/ENST00000625583
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005901
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0030863	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030863
GO_component	GO:0034704	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034704
GO_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0008013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008013
GO_function	GO:0015279	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015279
GO_function	GO:0045296	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045296
GO_function	GO:0070679	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070679
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0006828	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006828
GO_process	GO:0014051	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014051
GO_process	GO:0048709	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048709
GO_process	GO:0051480	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051480
GO_process	GO:0070509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070509
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.25.40.20	http://www.cathdb.info/version/latest/superfamily/1.25.40.20
GeneCards	TRPC4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TRPC4
GeneID	7223	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7223
GeneTree	ENSGT00760000119180	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119180
HGNC	HGNC:12336	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:12336
HOGENOM	HOG000151279	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000151279&db=HOGENOM6
HOVERGEN	HBG068337	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG068337&db=HOVERGEN
InParanoid	Q9UBN4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UBN4
IntAct	Q9UBN4	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9UBN4*
InterPro	IPR002110	http://www.ebi.ac.uk/interpro/entry/IPR002110
InterPro	IPR002153	http://www.ebi.ac.uk/interpro/entry/IPR002153
InterPro	IPR004729	http://www.ebi.ac.uk/interpro/entry/IPR004729
InterPro	IPR005460	http://www.ebi.ac.uk/interpro/entry/IPR005460
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR013555	http://www.ebi.ac.uk/interpro/entry/IPR013555
InterPro	IPR020683	http://www.ebi.ac.uk/interpro/entry/IPR020683
Jabion	7223	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7223
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:7223	http://www.genome.jp/dbget-bin/www_bget?hsa:7223
KEGG_Orthology	KO:K04967	http://www.genome.jp/dbget-bin/www_bget?KO:K04967
MIM	603651	http://www.ncbi.nlm.nih.gov/omim/603651
MINT	MINT-157838	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-157838
OMA	CILVDHR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CILVDHR
OrthoDB	EOG091G029I	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G029I
PANTHER	PTHR10117	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10117
PANTHER	PTHR10117:SF25	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10117:SF25
PRINTS	PR01097	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01097
PRINTS	PR01645	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01645
PROSITE	PS50088	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50088
PROSITE	PS50297	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50297
PSORT	swissprot:TRPC4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TRPC4_HUMAN
PSORT-B	swissprot:TRPC4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TRPC4_HUMAN
PSORT2	swissprot:TRPC4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TRPC4_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF08344	http://pfam.xfam.org/family/PF08344
PharmGKB	PA37009	http://www.pharmgkb.org/do/serve?objId=PA37009&objCls=Gene
Phobius	swissprot:TRPC4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TRPC4_HUMAN
PhylomeDB	Q9UBN4	http://phylomedb.org/?seqid=Q9UBN4
ProteinModelPortal	Q9UBN4	http://www.proteinmodelportal.org/query/uniprot/Q9UBN4
PubMed	11042129	http://www.ncbi.nlm.nih.gov/pubmed/11042129
PubMed	11163362	http://www.ncbi.nlm.nih.gov/pubmed/11163362
PubMed	11713258	http://www.ncbi.nlm.nih.gov/pubmed/11713258
PubMed	12032305	http://www.ncbi.nlm.nih.gov/pubmed/12032305
PubMed	12154080	http://www.ncbi.nlm.nih.gov/pubmed/12154080
PubMed	15057823	http://www.ncbi.nlm.nih.gov/pubmed/15057823
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15757897	http://www.ncbi.nlm.nih.gov/pubmed/15757897
PubMed	16144838	http://www.ncbi.nlm.nih.gov/pubmed/16144838
PubMed	16254212	http://www.ncbi.nlm.nih.gov/pubmed/16254212
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	17850865	http://www.ncbi.nlm.nih.gov/pubmed/17850865
PubMed	18048348	http://www.ncbi.nlm.nih.gov/pubmed/18048348
PubMed	19996314	http://www.ncbi.nlm.nih.gov/pubmed/19996314
PubMed	20164195	http://www.ncbi.nlm.nih.gov/pubmed/20164195
PubMed	8646775	http://www.ncbi.nlm.nih.gov/pubmed/8646775
Reactome	R-HSA-3295583	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3295583
Reactome	R-HSA-418890	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418890
RefSeq	NP_001129427	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001129427
RefSeq	NP_001129428	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001129428
RefSeq	NP_001129429	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001129429
RefSeq	NP_001129430	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001129430
RefSeq	NP_003297	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003297
RefSeq	NP_057263	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_057263
SMART	SM00248	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00248
STRING	9606.ENSP00000369003	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000369003&targetmode=cogs
SUPFAM	SSF48403	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48403
TCDB	1.A.4.1.12	http://www.tcdb.org/search/result.php?tc=1.A.4.1.12
TIGRFAMs	TIGR00870	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00870
UCSC	uc001uws	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001uws&org=rat
UniGene	Hs.262960	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.262960
UniProtKB	TRPC4_HUMAN	http://www.uniprot.org/uniprot/TRPC4_HUMAN
UniProtKB-AC	Q9UBN4	http://www.uniprot.org/uniprot/Q9UBN4
charge	swissprot:TRPC4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TRPC4_HUMAN
eggNOG	ENOG410XQ0Y	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ0Y
eggNOG	KOG3609	http://eggnogapi.embl.de/nog_data/html/tree/KOG3609
epestfind	swissprot:TRPC4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TRPC4_HUMAN
garnier	swissprot:TRPC4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TRPC4_HUMAN
helixturnhelix	swissprot:TRPC4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRPC4_HUMAN
hmoment	swissprot:TRPC4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TRPC4_HUMAN
iep	swissprot:TRPC4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TRPC4_HUMAN
inforesidue	swissprot:TRPC4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TRPC4_HUMAN
neXtProt	NX_Q9UBN4	http://www.nextprot.org/db/entry/NX_Q9UBN4
octanol	swissprot:TRPC4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TRPC4_HUMAN
pepcoil	swissprot:TRPC4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TRPC4_HUMAN
pepdigest	swissprot:TRPC4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TRPC4_HUMAN
pepinfo	swissprot:TRPC4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TRPC4_HUMAN
pepnet	swissprot:TRPC4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TRPC4_HUMAN
pepstats	swissprot:TRPC4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TRPC4_HUMAN
pepwheel	swissprot:TRPC4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TRPC4_HUMAN
pepwindow	swissprot:TRPC4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TRPC4_HUMAN
sigcleave	swissprot:TRPC4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TRPC4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GRIA4_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P48058-1; Sequence=Displayed; Name=2; IsoId=P48058-2; Sequence=VSP_042742, VSP_042743; Note=No experimental confirmation available.; 
# AltName	GRIA4_HUMAN	AMPA-selective glutamate receptor 4
# AltName	GRIA4_HUMAN	GluR-D
# AltName	GRIA4_HUMAN	Glutamate receptor ionotropic, AMPA 4
# BioGrid	109150	7
# CCDS	CCDS41707	-. [P48058-2]
# CCDS	CCDS8333	-. [P48058-1]
# ChiTaRS	GRIA4	human
# DOMAIN	GRIA4_HUMAN	The M4 transmembrane segment mediates tetramerization and is required for cell surface expression. {ECO 0000250}. 
# DrugBank	DB00898	Ethanol
# Ensembl	ENST00000282499	ENSP00000282499; ENSG00000152578. [P48058-1]
# Ensembl	ENST00000393125	ENSP00000376833; ENSG00000152578. [P48058-2]
# Ensembl	ENST00000428631	ENSP00000415551; ENSG00000152578. [P48058-2]
# Ensembl	ENST00000530497	ENSP00000435775; ENSG00000152578. [P48058-1]
# ExpressionAtlas	P48058	baseline and differential
# FUNCTION	GRIA4_HUMAN	Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. {ECO 0000269|PubMed 21172611}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030425	dendrite; IEA:UniProtKB-SubCell.
# GO_component	GO:0030666	endocytic vesicle membrane; TAS:Reactome.
# GO_component	GO:0032281	AMPA glutamate receptor complex; ISS:UniProtKB.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:1903561	extracellular vesicle; IDA:UniProtKB.
# GO_function	GO:0004970	ionotropic glutamate receptor activity; ISS:UniProtKB.
# GO_function	GO:0004971	AMPA glutamate receptor activity; IDA:UniProtKB.
# GO_function	GO:0005231	excitatory extracellular ligand-gated ion channel activity; TAS:Reactome.
# GO_function	GO:0005234	extracellular-glutamate-gated ion channel activity; IEA:InterPro.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007215	glutamate receptor signaling pathway; TAS:ProtInc.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# Genevisible	P48058	HS
# HGNC	HGNC:4574	GRIA4
# InterPro	IPR001320	Iontro_rcpt
# InterPro	IPR001508	Iono_rcpt_met
# InterPro	IPR001828	ANF_lig-bd_rcpt
# InterPro	IPR019594	Glu/Gly-bd
# InterPro	IPR028082	Peripla_BP_I
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04713	Circadian entrainment
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04724	Glutamatergic synapse
# KEGG_Pathway	ko04728	Dopaminergic synapse
# KEGG_Pathway	ko05031	Amphetamine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# MIM	138246	gene
# MISCELLANEOUS	GRIA4_HUMAN	The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate. 
# Organism	GRIA4_HUMAN	Homo sapiens (Human)
# PRINTS	PR00177	NMDARECEPTOR
# PTM	GRIA4_HUMAN	Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity). {ECO 0000250}. 
# PTM	GRIA4_HUMAN	Phosphorylated at Ser-862 by PRKCG; phosphorylation increases plasma membrane-associated GRI4 expression. {ECO 0000250}. 
# Pfam	PF00060	Lig_chan
# Pfam	PF01094	ANF_receptor
# Pfam	PF10613	Lig_chan-Glu_bd
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-399710	Activation of AMPA receptors
# Reactome	R-HSA-399719	Trafficking of AMPA receptors
# Reactome	R-HSA-416993	Trafficking of GluR2-containing AMPA receptors
# Reactome	R-HSA-438066	Unblocking of NMDA receptor, glutamate binding and activation
# Reactome	R-HSA-8849932	SALM protein interactions at the synapses
# RecName	GRIA4_HUMAN	Glutamate receptor 4
# RefSeq	NP_000820	NM_000829.3
# RefSeq	NP_001070711	NM_001077243.2
# RefSeq	NP_001070712	NM_001077244.1. [P48058-2]
# RefSeq	NP_001106283	NM_001112812.1. [P48058-2]
# RefSeq	XP_006718886	XM_006718823.1. [P48058-1]
# SIMILARITY	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA4 subfamily. {ECO	0000305}.
# SMART	SM00079	PBPe
# SMART	SM00918	Lig_chan-Glu_bd
# SUBCELLULAR LOCATION	GRIA4_HUMAN	Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=Interaction with CNIH2, CNIH3 and PRKCG promotes cell surface expression. {ECO 0000250}. 
# SUBUNIT	Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with EPB41L1 via its C-terminus (By similarity). Found in a complex with GRIA1, GRIA2, GRIA3, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CACNG5 and PRKCG (By similarity). {ECO	0000250}. 
# SUPFAM	SSF53822	SSF53822
# UCSC	uc001piu	human. [P48058-1]
# eggNOG	ENOG410XPSH	LUCA
# eggNOG	KOG1054	Eukaryota
BLAST	swissprot:GRIA4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GRIA4_HUMAN
BioCyc	ZFISH:ENSG00000152578-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000152578-MONOMER
COXPRESdb	2893	http://coxpresdb.jp/data/gene/2893.shtml
CleanEx	HS_GRIA4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GRIA4
DOI	10.1016/j.neuron.2010.11.026	http://dx.doi.org/10.1016/j.neuron.2010.11.026
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
EMBL	AP000641	http://www.ebi.ac.uk/ena/data/view/AP000641
EMBL	AP000673	http://www.ebi.ac.uk/ena/data/view/AP000673
EMBL	AP000813	http://www.ebi.ac.uk/ena/data/view/AP000813
EMBL	AP001561	http://www.ebi.ac.uk/ena/data/view/AP001561
EMBL	BC045546	http://www.ebi.ac.uk/ena/data/view/BC045546
EMBL	BC142654	http://www.ebi.ac.uk/ena/data/view/BC142654
EMBL	BC150209	http://www.ebi.ac.uk/ena/data/view/BC150209
EMBL	U16129	http://www.ebi.ac.uk/ena/data/view/U16129
Ensembl	ENST00000282499	http://www.ensembl.org/id/ENST00000282499
Ensembl	ENST00000393125	http://www.ensembl.org/id/ENST00000393125
Ensembl	ENST00000428631	http://www.ensembl.org/id/ENST00000428631
Ensembl	ENST00000530497	http://www.ensembl.org/id/ENST00000530497
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0030666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030666
GO_component	GO:0032281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032281
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_component	GO:1903561	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903561
GO_function	GO:0004970	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004970
GO_function	GO:0004971	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004971
GO_function	GO:0005231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005231
GO_function	GO:0005234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005234
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007215
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GeneCards	GRIA4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GRIA4
GeneID	2893	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2893
GeneTree	ENSGT00760000118920	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118920
H-InvDB	HIX0026176	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0026176
HGNC	HGNC:4574	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4574
HOGENOM	HOG000234372	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234372&db=HOGENOM6
HOVERGEN	HBG051839	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051839&db=HOVERGEN
InParanoid	P48058	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P48058
IntAct	P48058	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P48058*
InterPro	IPR001320	http://www.ebi.ac.uk/interpro/entry/IPR001320
InterPro	IPR001508	http://www.ebi.ac.uk/interpro/entry/IPR001508
InterPro	IPR001828	http://www.ebi.ac.uk/interpro/entry/IPR001828
InterPro	IPR019594	http://www.ebi.ac.uk/interpro/entry/IPR019594
InterPro	IPR028082	http://www.ebi.ac.uk/interpro/entry/IPR028082
Jabion	2893	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2893
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:2893	http://www.genome.jp/dbget-bin/www_bget?hsa:2893
KEGG_Orthology	KO:K05200	http://www.genome.jp/dbget-bin/www_bget?KO:K05200
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04713	http://www.genome.jp/kegg-bin/show_pathway?ko04713
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
KEGG_Pathway	ko04728	http://www.genome.jp/kegg-bin/show_pathway?ko04728
KEGG_Pathway	ko05031	http://www.genome.jp/kegg-bin/show_pathway?ko05031
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
MIM	138246	http://www.ncbi.nlm.nih.gov/omim/138246
MINT	MINT-95403	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-95403
OMA	STGPRKX	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=STGPRKX
OrthoDB	EOG091G11CB	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G11CB
PRINTS	PR00177	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00177
PSORT	swissprot:GRIA4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GRIA4_HUMAN
PSORT-B	swissprot:GRIA4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GRIA4_HUMAN
PSORT2	swissprot:GRIA4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GRIA4_HUMAN
Pfam	PF00060	http://pfam.xfam.org/family/PF00060
Pfam	PF01094	http://pfam.xfam.org/family/PF01094
Pfam	PF10613	http://pfam.xfam.org/family/PF10613
PharmGKB	PA28969	http://www.pharmgkb.org/do/serve?objId=PA28969&objCls=Gene
Phobius	swissprot:GRIA4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GRIA4_HUMAN
PhylomeDB	P48058	http://phylomedb.org/?seqid=P48058
ProteinModelPortal	P48058	http://www.proteinmodelportal.org/query/uniprot/P48058
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	21172611	http://www.ncbi.nlm.nih.gov/pubmed/21172611
PubMed	8589990	http://www.ncbi.nlm.nih.gov/pubmed/8589990
Reactome	R-HSA-399710	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-399710
Reactome	R-HSA-399719	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-399719
Reactome	R-HSA-416993	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-416993
Reactome	R-HSA-438066	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-438066
Reactome	R-HSA-8849932	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8849932
RefSeq	NP_000820	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000820
RefSeq	NP_001070711	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001070711
RefSeq	NP_001070712	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001070712
RefSeq	NP_001106283	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001106283
RefSeq	XP_006718886	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006718886
SMART	SM00079	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00079
SMART	SM00918	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00918
SMR	P48058	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P48058
STRING	9606.ENSP00000282499	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000282499&targetmode=cogs
SUPFAM	SSF53822	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822
UCSC	uc001piu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001piu&org=rat
UniGene	Hs.503743	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.503743
UniProtKB	GRIA4_HUMAN	http://www.uniprot.org/uniprot/GRIA4_HUMAN
UniProtKB-AC	P48058	http://www.uniprot.org/uniprot/P48058
charge	swissprot:GRIA4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GRIA4_HUMAN
eggNOG	ENOG410XPSH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPSH
eggNOG	KOG1054	http://eggnogapi.embl.de/nog_data/html/tree/KOG1054
epestfind	swissprot:GRIA4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GRIA4_HUMAN
garnier	swissprot:GRIA4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GRIA4_HUMAN
helixturnhelix	swissprot:GRIA4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GRIA4_HUMAN
hmoment	swissprot:GRIA4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GRIA4_HUMAN
iep	swissprot:GRIA4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GRIA4_HUMAN
inforesidue	swissprot:GRIA4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GRIA4_HUMAN
neXtProt	NX_P48058	http://www.nextprot.org/db/entry/NX_P48058
octanol	swissprot:GRIA4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GRIA4_HUMAN
pepcoil	swissprot:GRIA4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GRIA4_HUMAN
pepdigest	swissprot:GRIA4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GRIA4_HUMAN
pepinfo	swissprot:GRIA4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GRIA4_HUMAN
pepnet	swissprot:GRIA4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GRIA4_HUMAN
pepstats	swissprot:GRIA4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GRIA4_HUMAN
pepwheel	swissprot:GRIA4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GRIA4_HUMAN
pepwindow	swissprot:GRIA4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GRIA4_HUMAN
sigcleave	swissprot:GRIA4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GRIA4_HUMAN
## Database	ID	URL or Descriptions
# ChiTaRS	CHRNB2	human
# DISEASE	ACHB2_HUMAN	Epilepsy, nocturnal frontal lobe, 3 (ENFL3) [MIM 605375]  An autosomal dominant focal epilepsy characterized by nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements. {ECO 0000269|PubMed 11062464, ECO 0000269|PubMed 11104662}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00184	Nicotine
# DrugBank	DB00514	Dextromethorphan
# DrugBank	DB00674	Galantamine
# DrugBank	DB00898	Ethanol
# Ensembl	ENST00000368476	ENSP00000357461; ENSG00000160716
# ExpressionAtlas	P17787	baseline and differential
# FUNCTION	ACHB2_HUMAN	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions. {ECO 0000269|PubMed 22361591}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005892	acetylcholine-gated channel complex; IDA:UniProtKB.
# GO_component	GO:0009897	external side of plasma membrane; ISS:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0004889	acetylcholine-activated cation-selective channel activity; IDA:UniProtKB.
# GO_function	GO:0008144	drug binding; IEA:Ensembl.
# GO_function	GO:0015276	ligand-gated ion channel activity; TAS:DFLAT.
# GO_function	GO:0015464	acetylcholine receptor activity; IDA:UniProtKB.
# GO_function	GO:0042166	acetylcholine binding; IMP:UniProtKB.
# GO_process	GO:0001508	action potential; IEA:Ensembl.
# GO_process	GO:0001661	conditioned taste aversion; IEA:Ensembl.
# GO_process	GO:0001666	response to hypoxia; IDA:UniProtKB.
# GO_process	GO:0006811	ion transport; NAS:UniProtKB.
# GO_process	GO:0006816	calcium ion transport; ISS:UniProtKB.
# GO_process	GO:0006939	smooth muscle contraction; ISS:UniProtKB.
# GO_process	GO:0007165	signal transduction; IDA:UniProtKB.
# GO_process	GO:0007271	synaptic transmission, cholinergic; ISS:UniProtKB.
# GO_process	GO:0007274	neuromuscular synaptic transmission; IBA:GO_Central.
# GO_process	GO:0007601	visual perception; ISS:UniProtKB.
# GO_process	GO:0007605	sensory perception of sound; ISS:UniProtKB.
# GO_process	GO:0007612	learning; IMP:UniProtKB.
# GO_process	GO:0007613	memory; IMP:UniProtKB.
# GO_process	GO:0007626	locomotory behavior; ISS:UniProtKB.
# GO_process	GO:0008306	associative learning; ISS:UniProtKB.
# GO_process	GO:0008542	visual learning; IMP:UniProtKB.
# GO_process	GO:0014059	regulation of dopamine secretion; ISS:UniProtKB.
# GO_process	GO:0019233	sensory perception of pain; ISS:UniProtKB.
# GO_process	GO:0021562	vestibulocochlear nerve development; ISS:UniProtKB.
# GO_process	GO:0021631	optic nerve morphogenesis; ISS:UniProtKB.
# GO_process	GO:0021771	lateral geniculate nucleus development; ISS:UniProtKB.
# GO_process	GO:0021952	central nervous system projection neuron axonogenesis; ISS:UniProtKB.
# GO_process	GO:0030890	positive regulation of B cell proliferation; ISS:UniProtKB.
# GO_process	GO:0032225	regulation of synaptic transmission, dopaminergic; ISS:UniProtKB.
# GO_process	GO:0032226	positive regulation of synaptic transmission, dopaminergic; IEA:Ensembl.
# GO_process	GO:0033603	positive regulation of dopamine secretion; ISS:UniProtKB.
# GO_process	GO:0035094	response to nicotine; IDA:UniProtKB.
# GO_process	GO:0035095	behavioral response to nicotine; IMP:UniProtKB.
# GO_process	GO:0035176	social behavior; ISS:UniProtKB.
# GO_process	GO:0042053	regulation of dopamine metabolic process; ISS:UniProtKB.
# GO_process	GO:0042113	B cell activation; ISS:UniProtKB.
# GO_process	GO:0042220	response to cocaine; ISS:UniProtKB.
# GO_process	GO:0042320	regulation of circadian sleep/wake cycle, REM sleep; ISS:UniProtKB.
# GO_process	GO:0045188	regulation of circadian sleep/wake cycle, non-REM sleep; IEA:Ensembl.
# GO_process	GO:0045471	response to ethanol; ISS:UniProtKB.
# GO_process	GO:0045759	negative regulation of action potential; ISS:UniProtKB.
# GO_process	GO:0048814	regulation of dendrite morphogenesis; ISS:UniProtKB.
# GO_process	GO:0050877	neurological system process; IMP:UniProtKB.
# GO_process	GO:0050890	cognition; IMP:UniProtKB.
# GO_process	GO:0051291	protein heterooligomerization; IEA:Ensembl.
# GO_process	GO:0051899	membrane depolarization; ISS:UniProtKB.
# GO_process	GO:0051963	regulation of synapse assembly; ISS:UniProtKB.
# GO_process	GO:0060084	synaptic transmission involved in micturition; ISS:UniProtKB.
# GO_process	GO:0095500	acetylcholine receptor signaling pathway; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# Gene3D	1.20.120.370	-; 2.
# Gene3D	2.70.170.10	-; 1.
# Genevisible	P17787	HS
# HGNC	HGNC:1962	CHRNB2
# INTERACTION	ACHB2_HUMAN	P30532 CHRNA5; NbExp=3; IntAct=EBI-9008612, EBI-6657490; 
# IntAct	P17787	3
# InterPro	IPR002394	Nicotinic_acetylcholine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# InterPro	IPR027361	Acetylcholine_rcpt_TM
# InterPro	IPR032932	CHRNB2
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00807	[Nervous system disease] Nocturnal frontal lobe epilepsy (NFLE)
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04725	Cholinergic synapse
# KEGG_Pathway	ko05033	Nicotine addiction
# MIM	118507	gene
# MIM	605375	phenotype
# Organism	ACHB2_HUMAN	Homo sapiens (Human)
# Orphanet	98784	Autosomal dominant nocturnal frontal lobe epilepsy
# PANTHER	PTHR18945	PTHR18945; 2
# PANTHER	PTHR18945:SF80	PTHR18945:SF80; 2
# PDB	2GVT	Model; -; B/D/E=30-233
# PDB	2K58	NMR; -; B=231-265
# PDB	2K59	NMR; -; B=264-291
# PDB	2KSR	NMR; -; A=231-330, A=453-486
# PDB	2LM2	NMR; -; A=231-330, A=458-485
# PDB	5KXI	X-ray; 3.94 A; B/C/E=26-355, B/C/E=446-502
# PIR	S10505	S10505
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00254	NICOTINICR
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-629587	Highly sodium permeable acetylcholine nicotinic receptors
# Reactome	R-HSA-629594	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
# Reactome	R-HSA-629597	Highly calcium permeable nicotinic acetylcholine receptors
# RecName	ACHB2_HUMAN	Neuronal acetylcholine receptor subunit beta-2
# RefSeq	NP_000739	NM_000748.2
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta- 2/CHRNB2 sub-subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	ACHB2_HUMAN	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	ACHB2_HUMAN	Neuronal AChR is composed of two different types of subunits  alpha and beta. Beta-2 subunit can be combined to alpha- 2, alpha-3 or alpha-4 to give rise to functional receptors, complexes with beta-2 may be heteropentamers. Interacts with RIC3; which is required for proper folding and assembly. {ECO 0000269|PubMed 16120769, ECO 0000269|PubMed 22361591}. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TCDB	1.A.9.1	the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family
# TIGRFAMs	TIGR00860	LIC
# eggNOG	ENOG410XQGR	LUCA
# eggNOG	KOG3645	Eukaryota
BLAST	swissprot:ACHB2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ACHB2_HUMAN
BioCyc	ZFISH:ENSG00000160716-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000160716-MONOMER
COXPRESdb	1141	http://coxpresdb.jp/data/gene/1141.shtml
CleanEx	HS_CHRNB2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CHRNB2
DOI	10.1007/BF02736842	http://dx.doi.org/10.1007/BF02736842
DOI	10.1007/s003359901111	http://dx.doi.org/10.1007/s003359901111
DOI	10.1007/s004390050885	http://dx.doi.org/10.1007/s004390050885
DOI	10.1016/S0014-5793(96)01383-X	http://dx.doi.org/10.1016/S0014-5793(96)01383-X
DOI	10.1016/j.bbamem.2010.04.014	http://dx.doi.org/10.1016/j.bbamem.2010.04.014
DOI	10.1016/j.bbamem.2012.02.008	http://dx.doi.org/10.1016/j.bbamem.2012.02.008
DOI	10.1038/81566	http://dx.doi.org/10.1038/81566
DOI	10.1080/14622200110098419	http://dx.doi.org/10.1080/14622200110098419
DOI	10.1086/316946	http://dx.doi.org/10.1086/316946
DOI	10.1093/nar/18.14.4272	http://dx.doi.org/10.1093/nar/18.14.4272
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1124/mol.105.017459	http://dx.doi.org/10.1124/mol.105.017459
DrugBank	DB00184	http://www.drugbank.ca/drugs/DB00184
DrugBank	DB00514	http://www.drugbank.ca/drugs/DB00514
DrugBank	DB00674	http://www.drugbank.ca/drugs/DB00674
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
EMBL	AF077186	http://www.ebi.ac.uk/ena/data/view/AF077186
EMBL	AJ001935	http://www.ebi.ac.uk/ena/data/view/AJ001935
EMBL	AJ001936	http://www.ebi.ac.uk/ena/data/view/AJ001936
EMBL	AJ001937	http://www.ebi.ac.uk/ena/data/view/AJ001937
EMBL	AJ001938	http://www.ebi.ac.uk/ena/data/view/AJ001938
EMBL	AJ001939	http://www.ebi.ac.uk/ena/data/view/AJ001939
EMBL	BC075040	http://www.ebi.ac.uk/ena/data/view/BC075040
EMBL	BC075041	http://www.ebi.ac.uk/ena/data/view/BC075041
EMBL	U62437	http://www.ebi.ac.uk/ena/data/view/U62437
EMBL	X53179	http://www.ebi.ac.uk/ena/data/view/X53179
EMBL	Y08415	http://www.ebi.ac.uk/ena/data/view/Y08415
Ensembl	ENST00000368476	http://www.ensembl.org/id/ENST00000368476
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005892	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005892
GO_component	GO:0009897	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009897
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0004889	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004889
GO_function	GO:0008144	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008144
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_function	GO:0015464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015464
GO_function	GO:0042166	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042166
GO_process	GO:0001508	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001508
GO_process	GO:0001661	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001661
GO_process	GO:0001666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001666
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0006939	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006939
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007271
GO_process	GO:0007274	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007274
GO_process	GO:0007601	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007601
GO_process	GO:0007605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007605
GO_process	GO:0007612	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007612
GO_process	GO:0007613	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007613
GO_process	GO:0007626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007626
GO_process	GO:0008306	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008306
GO_process	GO:0008542	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008542
GO_process	GO:0014059	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014059
GO_process	GO:0019233	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019233
GO_process	GO:0021562	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021562
GO_process	GO:0021631	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021631
GO_process	GO:0021771	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021771
GO_process	GO:0021952	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021952
GO_process	GO:0030890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030890
GO_process	GO:0032225	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032225
GO_process	GO:0032226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032226
GO_process	GO:0033603	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033603
GO_process	GO:0035094	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035094
GO_process	GO:0035095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035095
GO_process	GO:0035176	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035176
GO_process	GO:0042053	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042053
GO_process	GO:0042113	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042113
GO_process	GO:0042220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042220
GO_process	GO:0042320	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042320
GO_process	GO:0045188	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045188
GO_process	GO:0045471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045471
GO_process	GO:0045759	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045759
GO_process	GO:0048814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048814
GO_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GO_process	GO:0050890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050890
GO_process	GO:0051291	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051291
GO_process	GO:0051899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051899
GO_process	GO:0051963	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051963
GO_process	GO:0060084	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060084
GO_process	GO:0095500	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0095500
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
Gene3D	1.20.120.370	http://www.cathdb.info/version/latest/superfamily/1.20.120.370
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	CHRNB2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CHRNB2
GeneID	1141	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1141
GeneTree	ENSGT00760000118930	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118930
HGNC	HGNC:1962	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1962
HOGENOM	HOG000006757	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006757&db=HOGENOM6
HOVERGEN	HBG003756	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003756&db=HOVERGEN
InParanoid	P17787	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P17787
IntAct	P17787	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P17787*
InterPro	IPR002394	http://www.ebi.ac.uk/interpro/entry/IPR002394
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
InterPro	IPR027361	http://www.ebi.ac.uk/interpro/entry/IPR027361
InterPro	IPR032932	http://www.ebi.ac.uk/interpro/entry/IPR032932
Jabion	1141	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1141
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00807	http://www.genome.jp/dbget-bin/www_bget?H00807
KEGG_Gene	hsa:1141	http://www.genome.jp/dbget-bin/www_bget?hsa:1141
KEGG_Orthology	KO:K04813	http://www.genome.jp/dbget-bin/www_bget?KO:K04813
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04725	http://www.genome.jp/kegg-bin/show_pathway?ko04725
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
MIM	118507	http://www.ncbi.nlm.nih.gov/omim/118507
MIM	605375	http://www.ncbi.nlm.nih.gov/omim/605375
MINT	MINT-6629945	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6629945
OMA	KEDSDPC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KEDSDPC
Orphanet	98784	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98784
OrthoDB	EOG091G0R20	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0R20
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PANTHER	PTHR18945:SF80	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945:SF80
PDB	2GVT	http://www.ebi.ac.uk/pdbe-srv/view/entry/2GVT
PDB	2K58	http://www.ebi.ac.uk/pdbe-srv/view/entry/2K58
PDB	2K59	http://www.ebi.ac.uk/pdbe-srv/view/entry/2K59
PDB	2KSR	http://www.ebi.ac.uk/pdbe-srv/view/entry/2KSR
PDB	2LM2	http://www.ebi.ac.uk/pdbe-srv/view/entry/2LM2
PDB	5KXI	http://www.ebi.ac.uk/pdbe-srv/view/entry/5KXI
PDBsum	2GVT	http://www.ebi.ac.uk/pdbsum/2GVT
PDBsum	2K58	http://www.ebi.ac.uk/pdbsum/2K58
PDBsum	2K59	http://www.ebi.ac.uk/pdbsum/2K59
PDBsum	2KSR	http://www.ebi.ac.uk/pdbsum/2KSR
PDBsum	2LM2	http://www.ebi.ac.uk/pdbsum/2LM2
PDBsum	5KXI	http://www.ebi.ac.uk/pdbsum/5KXI
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00254	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00254
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:ACHB2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ACHB2_HUMAN
PSORT-B	swissprot:ACHB2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ACHB2_HUMAN
PSORT2	swissprot:ACHB2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ACHB2_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA115	http://www.pharmgkb.org/do/serve?objId=PA115&objCls=Gene
Phobius	swissprot:ACHB2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ACHB2_HUMAN
PhylomeDB	P17787	http://phylomedb.org/?seqid=P17787
ProteinModelPortal	P17787	http://www.proteinmodelportal.org/query/uniprot/P17787
PubMed	10441742	http://www.ncbi.nlm.nih.gov/pubmed/10441742
PubMed	11062464	http://www.ncbi.nlm.nih.gov/pubmed/11062464
PubMed	11104662	http://www.ncbi.nlm.nih.gov/pubmed/11104662
PubMed	11906688	http://www.ncbi.nlm.nih.gov/pubmed/11906688
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16120769	http://www.ncbi.nlm.nih.gov/pubmed/16120769
PubMed	20441771	http://www.ncbi.nlm.nih.gov/pubmed/20441771
PubMed	22361591	http://www.ncbi.nlm.nih.gov/pubmed/22361591
PubMed	2377478	http://www.ncbi.nlm.nih.gov/pubmed/2377478
PubMed	8906617	http://www.ncbi.nlm.nih.gov/pubmed/8906617
PubMed	9009220	http://www.ncbi.nlm.nih.gov/pubmed/9009220
PubMed	9921897	http://www.ncbi.nlm.nih.gov/pubmed/9921897
Reactome	R-HSA-629587	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-629587
Reactome	R-HSA-629594	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-629594
Reactome	R-HSA-629597	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-629597
RefSeq	NP_000739	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000739
SMR	P17787	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P17787
STRING	9606.ENSP00000357461	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000357461&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TCDB	1.A.9.1	http://www.tcdb.org/search/result.php?tc=1.A.9.1
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UniGene	Hs.2306	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.2306
UniProtKB	ACHB2_HUMAN	http://www.uniprot.org/uniprot/ACHB2_HUMAN
UniProtKB-AC	P17787	http://www.uniprot.org/uniprot/P17787
charge	swissprot:ACHB2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ACHB2_HUMAN
eggNOG	ENOG410XQGR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQGR
eggNOG	KOG3645	http://eggnogapi.embl.de/nog_data/html/tree/KOG3645
epestfind	swissprot:ACHB2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ACHB2_HUMAN
garnier	swissprot:ACHB2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ACHB2_HUMAN
helixturnhelix	swissprot:ACHB2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACHB2_HUMAN
hmoment	swissprot:ACHB2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ACHB2_HUMAN
iep	swissprot:ACHB2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ACHB2_HUMAN
inforesidue	swissprot:ACHB2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ACHB2_HUMAN
neXtProt	NX_P17787	http://www.nextprot.org/db/entry/NX_P17787
octanol	swissprot:ACHB2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ACHB2_HUMAN
pepcoil	swissprot:ACHB2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ACHB2_HUMAN
pepdigest	swissprot:ACHB2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ACHB2_HUMAN
pepinfo	swissprot:ACHB2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ACHB2_HUMAN
pepnet	swissprot:ACHB2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ACHB2_HUMAN
pepstats	swissprot:ACHB2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ACHB2_HUMAN
pepwheel	swissprot:ACHB2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ACHB2_HUMAN
pepwindow	swissprot:ACHB2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ACHB2_HUMAN
sigcleave	swissprot:ACHB2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ACHB2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNH8_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96L42-1; Sequence=Displayed; Name=2; IsoId=Q96L42-2; Sequence=VSP_057036, VSP_057037, VSP_057038, VSP_057039; Note=No experimental confirmation available.; 
# AltName	KCNH8_HUMAN	ELK1
# AltName	KCNH8_HUMAN	Ether-a-go-go-like potassium channel 3
# AltName	KCNH8_HUMAN	Voltage-gated potassium channel subunit Kv12.1
# CCDS	CCDS2632	-. [Q96L42-1]
# ChiTaRS	KCNH8	human
# DOMAIN	KCNH8_HUMAN	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. 
# Ensembl	ENST00000328405	ENSP00000328813; ENSG00000183960. [Q96L42-1]
# ExpressionAtlas	Q96L42	baseline and differential
# FUNCTION	KCNH8_HUMAN	Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly. 
# GO_component	GO:0005622	intracellular; IEA:GOC.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0000155	phosphorelay sensor kinase activity; IEA:InterPro.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IBA:GO_Central.
# GO_process	GO:0042391	regulation of membrane potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005622	intracellular
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0016301	kinase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# Gene3D	2.60.120.10	-; 1.
# Genevisible	Q96L42	HS
# HGNC	HGNC:18864	KCNH8
# InterPro	IPR000014	PAS
# InterPro	IPR000595	cNMP-bd_dom
# InterPro	IPR000700	PAS-assoc_C
# InterPro	IPR001610	PAC
# InterPro	IPR003938	K_chnl_volt-dep_EAG/ELK/ERG
# InterPro	IPR003950	K_chnl_volt-dep_ELK
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR014710	RmlC-like_jellyroll
# InterPro	IPR018490	cNMP-bd-like
# KEGG_Brite	ko04040	Ion channels
# MIM	608260	gene
# Organism	KCNH8_HUMAN	Homo sapiens (Human)
# PRINTS	PR01463	EAGCHANLFMLY
# PRINTS	PR01465	ELKCHANNEL
# PROSITE	PS50042	CNMP_BINDING_3
# PROSITE	PS50113	PAC
# Pfam	PF00027	cNMP_binding
# Pfam	PF00520	Ion_trans
# Pfam	PF13426	PAS_9
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# RecName	KCNH8_HUMAN	Potassium voltage-gated channel subfamily H member 8
# RefSeq	NP_653234	NM_144633.2. [Q96L42-1]
# SIMILARITY	Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.1/KCNH8 sub-subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 PAC (PAS-associated C-terminal) domain. {ECO:0000255|PROSITE-ProRule	PRU00141}. 
# SIMILARITY	Contains 1 PAS (PER-ARNT-SIM) domain. {ECO	0000305}.
# SIMILARITY	Contains 1 cyclic nucleotide-binding domain. {ECO:0000255|PROSITE-ProRule	PRU00060}. 
# SMART	SM00086	PAC
# SMART	SM00100	cNMP
# SUBCELLULAR LOCATION	KCNH8_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	KCNH8_HUMAN	The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. 
# SUPFAM	SSF51206	SSF51206
# SUPFAM	SSF55785	SSF55785
# TIGRFAMs	TIGR00229	sensory_box
# TISSUE SPECIFICITY	Primarily expressed in the nervous system. {ECO:0000269|PubMed	12890647}. 
# UCSC	uc003cbk	human. [Q96L42-1]
# eggNOG	ENOG410XPSE	LUCA
# eggNOG	KOG0498	Eukaryota
BLAST	swissprot:KCNH8_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNH8_HUMAN
COXPRESdb	131096	http://coxpresdb.jp/data/gene/131096.shtml
CleanEx	HS_KCNH8	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNH8
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1089/108705702753520369	http://dx.doi.org/10.1089/108705702753520369
DOI	10.1152/ajpcell.00179.2003	http://dx.doi.org/10.1152/ajpcell.00179.2003
EMBL	AB209053	http://www.ebi.ac.uk/ena/data/view/AB209053
EMBL	AC015542	http://www.ebi.ac.uk/ena/data/view/AC015542
EMBL	AC061958	http://www.ebi.ac.uk/ena/data/view/AC061958
EMBL	AC099538	http://www.ebi.ac.uk/ena/data/view/AC099538
EMBL	AC116098	http://www.ebi.ac.uk/ena/data/view/AC116098
EMBL	AC135452	http://www.ebi.ac.uk/ena/data/view/AC135452
EMBL	AC138315	http://www.ebi.ac.uk/ena/data/view/AC138315
EMBL	AK294759	http://www.ebi.ac.uk/ena/data/view/AK294759
EMBL	AY053503	http://www.ebi.ac.uk/ena/data/view/AY053503
Ensembl	ENST00000328405	http://www.ensembl.org/id/ENST00000328405
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0000155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0016301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	2.60.120.10	http://www.cathdb.info/version/latest/superfamily/2.60.120.10
GeneCards	KCNH8	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNH8
GeneID	131096	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=131096
GeneTree	ENSGT00760000118772	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118772
H-InvDB	HIX0030767	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0030767
HGNC	HGNC:18864	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18864
HOGENOM	HOG000230794	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230794&db=HOGENOM6
HOVERGEN	HBG052232	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052232&db=HOVERGEN
InParanoid	Q96L42	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96L42
InterPro	IPR000014	http://www.ebi.ac.uk/interpro/entry/IPR000014
InterPro	IPR000595	http://www.ebi.ac.uk/interpro/entry/IPR000595
InterPro	IPR000700	http://www.ebi.ac.uk/interpro/entry/IPR000700
InterPro	IPR001610	http://www.ebi.ac.uk/interpro/entry/IPR001610
InterPro	IPR003938	http://www.ebi.ac.uk/interpro/entry/IPR003938
InterPro	IPR003950	http://www.ebi.ac.uk/interpro/entry/IPR003950
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR014710	http://www.ebi.ac.uk/interpro/entry/IPR014710
InterPro	IPR018490	http://www.ebi.ac.uk/interpro/entry/IPR018490
Jabion	131096	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=131096
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:131096	http://www.genome.jp/dbget-bin/www_bget?hsa:131096
KEGG_Orthology	KO:K04911	http://www.genome.jp/dbget-bin/www_bget?KO:K04911
MIM	608260	http://www.ncbi.nlm.nih.gov/omim/608260
OMA	NGSSFWC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NGSSFWC
OrthoDB	EOG091G0OXR	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0OXR
PRINTS	PR01463	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01463
PRINTS	PR01465	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01465
PROSITE	PS50042	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50042
PROSITE	PS50113	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50113
PSORT	swissprot:KCNH8_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNH8_HUMAN
PSORT-B	swissprot:KCNH8_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNH8_HUMAN
PSORT2	swissprot:KCNH8_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNH8_HUMAN
Pfam	PF00027	http://pfam.xfam.org/family/PF00027
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF13426	http://pfam.xfam.org/family/PF13426
PharmGKB	PA38724	http://www.pharmgkb.org/do/serve?objId=PA38724&objCls=Gene
Phobius	swissprot:KCNH8_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNH8_HUMAN
PhylomeDB	Q96L42	http://phylomedb.org/?seqid=Q96L42
ProteinModelPortal	Q96L42	http://www.proteinmodelportal.org/query/uniprot/Q96L42
PubMed	11897058	http://www.ncbi.nlm.nih.gov/pubmed/11897058
PubMed	12890647	http://www.ncbi.nlm.nih.gov/pubmed/12890647
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
RefSeq	NP_653234	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_653234
SMART	SM00086	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00086
SMART	SM00100	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00100
SMR	Q96L42	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q96L42
STRING	9606.ENSP00000328813	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000328813&targetmode=cogs
SUPFAM	SSF51206	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51206
SUPFAM	SSF55785	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55785
TIGRFAMs	TIGR00229	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00229
UCSC	uc003cbk	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003cbk&org=rat
UniGene	Hs.475656	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.475656
UniProtKB	KCNH8_HUMAN	http://www.uniprot.org/uniprot/KCNH8_HUMAN
UniProtKB-AC	Q96L42	http://www.uniprot.org/uniprot/Q96L42
charge	swissprot:KCNH8_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNH8_HUMAN
eggNOG	ENOG410XPSE	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPSE
eggNOG	KOG0498	http://eggnogapi.embl.de/nog_data/html/tree/KOG0498
epestfind	swissprot:KCNH8_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNH8_HUMAN
garnier	swissprot:KCNH8_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNH8_HUMAN
helixturnhelix	swissprot:KCNH8_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNH8_HUMAN
hmoment	swissprot:KCNH8_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNH8_HUMAN
iep	swissprot:KCNH8_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNH8_HUMAN
inforesidue	swissprot:KCNH8_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNH8_HUMAN
neXtProt	NX_Q96L42	http://www.nextprot.org/db/entry/NX_Q96L42
octanol	swissprot:KCNH8_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNH8_HUMAN
pepcoil	swissprot:KCNH8_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNH8_HUMAN
pepdigest	swissprot:KCNH8_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNH8_HUMAN
pepinfo	swissprot:KCNH8_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNH8_HUMAN
pepnet	swissprot:KCNH8_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNH8_HUMAN
pepstats	swissprot:KCNH8_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNH8_HUMAN
pepwheel	swissprot:KCNH8_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNH8_HUMAN
pepwindow	swissprot:KCNH8_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNH8_HUMAN
sigcleave	swissprot:KCNH8_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNH8_HUMAN
## Database	ID	URL or Descriptions
# AltName	CXA3_HUMAN	Connexin-46
# BioGrid	108967	3
# DISEASE	CXA3_HUMAN	Cataract 14, multiple types (CTRCT14) [MIM 601885]  An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. CTRCT14 includes zonular pulverulent cataract, among others. Zonular or lamellar cataracts are opacities, broad or narrow, usually consisting of powdery white dots affecting only certain layers or zones between the cortex and nucleus of an otherwise clear lens. The opacity may be so dense as to render the entire central region of the lens completely opaque, or so translucent that vision is hardly if at all impeded. Usually sharply separated from a clear cortex outside them, they may have projections from their outer edges known as riders or spokes. {ECO 0000269|PubMed 10205266, ECO 0000269|PubMed 10746562, ECO 0000269|PubMed 14627959, ECO 0000269|PubMed 15208569, ECO 0000269|PubMed 15286166, ECO 0000269|PubMed 15448617, ECO 0000269|PubMed 16234473, ECO 0000269|PubMed 16254549, ECO 0000269|PubMed 16885921, ECO 0000269|PubMed 16971895, ECO 0000269|PubMed 17615540, ECO 0000269|PubMed 17893674, ECO 0000269|PubMed 20431721, ECO 0000269|PubMed 21552498, ECO 0000269|PubMed 21647269, ECO 0000269|PubMed 21681855, ECO 0000269|PubMed 21897748, ECO 0000269|PubMed 22312188, ECO 0000269|PubMed 24772942, ECO 0000269|PubMed 25635993, ECO 0000269|PubMed 26683566}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000241125	ENSP00000241125; ENSG00000121743
# FUNCTION	CXA3_HUMAN	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. 
# GO_component	GO:0005922	connexin complex; IEA:InterPro.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005243	gap junction channel activity; IEA:InterPro.
# GO_process	GO:0006810	transport; NAS:ProtInc.
# GO_process	GO:0007267	cell-cell signaling; TAS:ProtInc.
# GO_process	GO:0007601	visual perception; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0050877	neurological system process
# Genevisible	Q9Y6H8	HS
# HGNC	HGNC:4277	GJA3
# InterPro	IPR000500	Connexin
# InterPro	IPR002262	Connexin46
# InterPro	IPR013092	Connexin_N
# InterPro	IPR017990	Connexin_CS
# InterPro	IPR019570	Connexin_CCC
# KEGG_Disease	H01202	[Eye disease] Cataract
# MIM	121015	gene
# MIM	601885	phenotype
# Organism	CXA3_HUMAN	Homo sapiens (Human)
# Orphanet	98984	Pulverulent cataract
# Orphanet	98986	Coppock-like cataract
# Orphanet	98991	Nuclear cataract
# Orphanet	98993	Posterior polar cataract
# PANTHER	PTHR11984	PTHR11984; 2
# PANTHER	PTHR11984:SF12	PTHR11984:SF12; 2
# PRINTS	PR00206	CONNEXIN
# PRINTS	PR01133	CONNEXINA3
# PROSITE	PS00407	CONNEXINS_1
# PROSITE	PS00408	CONNEXINS_2
# Pfam	PF00029	Connexin
# Proteomes	UP000005640	Chromosome 13
# Reactome	R-HSA-190861	Gap junction assembly
# RecName	CXA3_HUMAN	Gap junction alpha-3 protein
# RefSeq	NP_068773	NM_021954.3
# RefSeq	XP_011533350	XM_011535048.2
# SIMILARITY	Belongs to the connexin family. Alpha-type (group II) subfamily. {ECO	0000305}.
# SMART	SM00037	CNX
# SMART	SM01089	Connexin_CCC
# SUBCELLULAR LOCATION	CXA3_HUMAN	Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. 
# SUBUNIT	CXA3_HUMAN	A connexon is composed of a hexamer of connexins. This particular connexin is a component of lens fiber gap junctions, can form both junctional and non-junctional ("hemi-") channels. 
# TCDB	1.A.24.1	the gap junction-forming connexin (connexin) family
# UCSC	uc001umx	human
# eggNOG	ENOG410IF3Z	Eukaryota
# eggNOG	ENOG410ZC96	LUCA
BLAST	swissprot:CXA3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CXA3_HUMAN
BioCyc	ZFISH:ENSG00000121743-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000121743-MONOMER
COXPRESdb	2700	http://coxpresdb.jp/data/gene/2700.shtml
CleanEx	HS_GJA3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GJA3
DOI	10.1002/humu.21552	http://dx.doi.org/10.1002/humu.21552
DOI	10.1007/s004390051029	http://dx.doi.org/10.1007/s004390051029
DOI	10.1038/nature02379	http://dx.doi.org/10.1038/nature02379
DOI	10.1086/302383	http://dx.doi.org/10.1086/302383
DOI	10.1089/dna.2015.3125	http://dx.doi.org/10.1089/dna.2015.3125
DOI	10.1097/OPX.0000000000000518	http://dx.doi.org/10.1097/OPX.0000000000000518
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1136/bjo.2005.075184	http://dx.doi.org/10.1136/bjo.2005.075184
DOI	10.1136/jmg.2004.018333	http://dx.doi.org/10.1136/jmg.2004.018333
EMBL	AF075290	http://www.ebi.ac.uk/ena/data/view/AF075290
EMBL	AL138688	http://www.ebi.ac.uk/ena/data/view/AL138688
EMBL	BC121137	http://www.ebi.ac.uk/ena/data/view/BC121137
Ensembl	ENST00000241125	http://www.ensembl.org/id/ENST00000241125
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005922	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005922
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005243	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005243
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GO_process	GO:0007601	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007601
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	GJA3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GJA3
GeneID	2700	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2700
GeneTree	ENSGT00840000129674	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00840000129674
H-InvDB	HIX0037357	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0037357
HGNC	HGNC:4277	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4277
HOGENOM	HOG000231127	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231127&db=HOGENOM6
HOVERGEN	HBG009576	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG009576&db=HOVERGEN
InParanoid	Q9Y6H8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y6H8
InterPro	IPR000500	http://www.ebi.ac.uk/interpro/entry/IPR000500
InterPro	IPR002262	http://www.ebi.ac.uk/interpro/entry/IPR002262
InterPro	IPR013092	http://www.ebi.ac.uk/interpro/entry/IPR013092
InterPro	IPR017990	http://www.ebi.ac.uk/interpro/entry/IPR017990
InterPro	IPR019570	http://www.ebi.ac.uk/interpro/entry/IPR019570
Jabion	2700	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2700
KEGG_Disease	H01202	http://www.genome.jp/dbget-bin/www_bget?H01202
KEGG_Gene	hsa:2700	http://www.genome.jp/dbget-bin/www_bget?hsa:2700
KEGG_Orthology	KO:K07612	http://www.genome.jp/dbget-bin/www_bget?KO:K07612
MIM	121015	http://www.ncbi.nlm.nih.gov/omim/121015
MIM	601885	http://www.ncbi.nlm.nih.gov/omim/601885
OMA	IGFPPYY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IGFPPYY
Orphanet	98984	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98984
Orphanet	98986	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98986
Orphanet	98991	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98991
Orphanet	98993	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98993
OrthoDB	EOG091G0BF2	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0BF2
PANTHER	PTHR11984	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11984
PANTHER	PTHR11984:SF12	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11984:SF12
PRINTS	PR00206	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00206
PRINTS	PR01133	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01133
PROSITE	PS00407	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00407
PROSITE	PS00408	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00408
PSORT	swissprot:CXA3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CXA3_HUMAN
PSORT-B	swissprot:CXA3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CXA3_HUMAN
PSORT2	swissprot:CXA3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CXA3_HUMAN
Pfam	PF00029	http://pfam.xfam.org/family/PF00029
Phobius	swissprot:CXA3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CXA3_HUMAN
PhylomeDB	Q9Y6H8	http://phylomedb.org/?seqid=Q9Y6H8
ProteinModelPortal	Q9Y6H8	http://www.proteinmodelportal.org/query/uniprot/Q9Y6H8
PubMed	10205266	http://www.ncbi.nlm.nih.gov/pubmed/10205266
PubMed	10746562	http://www.ncbi.nlm.nih.gov/pubmed/10746562
PubMed	14627959	http://www.ncbi.nlm.nih.gov/pubmed/14627959
PubMed	15057823	http://www.ncbi.nlm.nih.gov/pubmed/15057823
PubMed	15208569	http://www.ncbi.nlm.nih.gov/pubmed/15208569
PubMed	15286166	http://www.ncbi.nlm.nih.gov/pubmed/15286166
PubMed	15448617	http://www.ncbi.nlm.nih.gov/pubmed/15448617
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16234473	http://www.ncbi.nlm.nih.gov/pubmed/16234473
PubMed	16254549	http://www.ncbi.nlm.nih.gov/pubmed/16254549
PubMed	16885921	http://www.ncbi.nlm.nih.gov/pubmed/16885921
PubMed	16971895	http://www.ncbi.nlm.nih.gov/pubmed/16971895
PubMed	17615540	http://www.ncbi.nlm.nih.gov/pubmed/17615540
PubMed	17893674	http://www.ncbi.nlm.nih.gov/pubmed/17893674
PubMed	20431721	http://www.ncbi.nlm.nih.gov/pubmed/20431721
PubMed	21552498	http://www.ncbi.nlm.nih.gov/pubmed/21552498
PubMed	21647269	http://www.ncbi.nlm.nih.gov/pubmed/21647269
PubMed	21681855	http://www.ncbi.nlm.nih.gov/pubmed/21681855
PubMed	21897748	http://www.ncbi.nlm.nih.gov/pubmed/21897748
PubMed	22312188	http://www.ncbi.nlm.nih.gov/pubmed/22312188
PubMed	24772942	http://www.ncbi.nlm.nih.gov/pubmed/24772942
PubMed	25635993	http://www.ncbi.nlm.nih.gov/pubmed/25635993
PubMed	26683566	http://www.ncbi.nlm.nih.gov/pubmed/26683566
Reactome	R-HSA-190861	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-190861
RefSeq	NP_068773	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_068773
RefSeq	XP_011533350	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011533350
SMART	SM00037	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00037
SMART	SM01089	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01089
STRING	9606.ENSP00000241125	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000241125&targetmode=cogs
TCDB	1.A.24.1	http://www.tcdb.org/search/result.php?tc=1.A.24.1
UCSC	uc001umx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001umx&org=rat
UniGene	Hs.130313	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.130313
UniProtKB	CXA3_HUMAN	http://www.uniprot.org/uniprot/CXA3_HUMAN
UniProtKB-AC	Q9Y6H8	http://www.uniprot.org/uniprot/Q9Y6H8
charge	swissprot:CXA3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CXA3_HUMAN
eggNOG	ENOG410IF3Z	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IF3Z
eggNOG	ENOG410ZC96	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZC96
epestfind	swissprot:CXA3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CXA3_HUMAN
garnier	swissprot:CXA3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CXA3_HUMAN
helixturnhelix	swissprot:CXA3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CXA3_HUMAN
hmoment	swissprot:CXA3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CXA3_HUMAN
iep	swissprot:CXA3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CXA3_HUMAN
inforesidue	swissprot:CXA3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CXA3_HUMAN
neXtProt	NX_Q9Y6H8	http://www.nextprot.org/db/entry/NX_Q9Y6H8
octanol	swissprot:CXA3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CXA3_HUMAN
pepcoil	swissprot:CXA3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CXA3_HUMAN
pepdigest	swissprot:CXA3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CXA3_HUMAN
pepinfo	swissprot:CXA3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CXA3_HUMAN
pepnet	swissprot:CXA3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CXA3_HUMAN
pepstats	swissprot:CXA3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CXA3_HUMAN
pepwheel	swissprot:CXA3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CXA3_HUMAN
pepwindow	swissprot:CXA3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CXA3_HUMAN
sigcleave	swissprot:CXA3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CXA3_HUMAN
## Database	ID	URL or Descriptions
# AltName	VATE2_HUMAN	Vacuolar proton pump subunit E 2
# BioGrid	124715	4
# Ensembl	ENST00000306448	ENSP00000304891; ENSG00000250565
# Ensembl	ENST00000522587	ENSP00000428141; ENSG00000250565
# ExpressionAtlas	Q96A05	baseline and differential
# FUNCTION	VATE2_HUMAN	Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This isoform is essential for energy coupling involved in acidification of acrosome (By similarity). {ECO 0000250}. 
# GO_component	GO:0001669	acrosomal vesicle; IEA:Ensembl.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain; IEA:InterPro.
# GO_function	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism; IEA:Ensembl.
# GO_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
# GO_process	GO:0008286	insulin receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0015991	ATP hydrolysis coupled proton transport; IEA:Ensembl.
# GO_process	GO:0016241	regulation of macroautophagy; NAS:ParkinsonsUK-UCL.
# GO_process	GO:0033572	transferrin transport; TAS:Reactome.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0090383	phagosome acidification; TAS:Reactome.
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q96A05	HS
# HAMAP	MF_00311	ATP_synth_E_arch
# HGNC	HGNC:18125	ATP6V1E2
# INTERACTION	VATE2_HUMAN	O75348 ATP6V1G1; NbExp=6; IntAct=EBI-8650380, EBI-711802; Q9BUW7 C9orf16; NbExp=3; IntAct=EBI-8650380, EBI-752084; 
# IntAct	Q96A05	2
# InterPro	IPR002842	ATPase_V1/A1-cplx_esu
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04966	Collecting duct acid secretion
# KEGG_Pathway	ko05110	Vibrio cholerae infection
# KEGG_Pathway	ko05120	Epithelial cell signaling in Helicobacter pylori infection
# KEGG_Pathway	ko05323	Rheumatoid arthritis
# Organism	VATE2_HUMAN	Homo sapiens (Human)
# Pfam	PF01991	vATP-synt_E
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-1222556	ROS, RNS production in response to bacteria
# Reactome	R-HSA-77387	Insulin receptor recycling
# Reactome	R-HSA-917977	Transferrin endocytosis and recycling
# Reactome	R-HSA-983712	Ion channel transport
# RecName	VATE2_HUMAN	V-type proton ATPase subunit E 2
# RefSeq	NP_001304992	NM_001318063.1
# RefSeq	XP_005264690	XM_005264633.2
# RefSeq	XP_005264691	XM_005264634.2
# RefSeq	XP_011531450	XM_011533148.2
# RefSeq	XP_011531451	XM_011533149.2
# RefSeq	XP_011531452	XM_011533150.2
# RefSeq	XP_011531453	XM_011533151.2
# RefSeq	XP_011531454	XM_011533152.2
# RefSeq	XP_011531455	XM_011533153.2
# RefSeq	XP_016860714	XM_017005225.1
# RefSeq	XP_016860715	XM_017005226.1
# SIMILARITY	Belongs to the V-ATPase E subunit family. {ECO	0000305}.
# SUBUNIT	V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components	 a, c, c', c'' and d). 
# TISSUE SPECIFICITY	Testis specific. {ECO:0000269|PubMed	12036578}. 
# UCSC	uc002ruy	human
# eggNOG	COG1390	LUCA
# eggNOG	KOG1664	Eukaryota
BLAST	swissprot:VATE2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VATE2_HUMAN
BioCyc	MetaCyc:HS10256-MONOMER	http://biocyc.org/getid?id=MetaCyc:HS10256-MONOMER
BioCyc	ZFISH:HS10256-MONOMER	http://biocyc.org/getid?id=ZFISH:HS10256-MONOMER
COG	COG1390	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1390
COXPRESdb	90423	http://coxpresdb.jp/data/gene/90423.shtml
CleanEx	HS_ATP6V1E2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP6V1E2
DOI	10.1016/S0378-1119(02)00542-5	http://dx.doi.org/10.1016/S0378-1119(02)00542-5
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB074759	http://www.ebi.ac.uk/ena/data/view/AB074759
EMBL	AC018682	http://www.ebi.ac.uk/ena/data/view/AC018682
EMBL	AK058055	http://www.ebi.ac.uk/ena/data/view/AK058055
EMBL	BC008981	http://www.ebi.ac.uk/ena/data/view/BC008981
EMBL	BC034808	http://www.ebi.ac.uk/ena/data/view/BC034808
Ensembl	ENST00000306448	http://www.ensembl.org/id/ENST00000306448
Ensembl	ENST00000522587	http://www.ensembl.org/id/ENST00000522587
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0001669	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001669
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0033178	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033178
GO_function	GO:0008553	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008553
GO_function	GO:0046961	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046961
GO_process	GO:0008286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008286
GO_process	GO:0015991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015991
GO_process	GO:0016241	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016241
GO_process	GO:0033572	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033572
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0090383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090383
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ATP6V1E2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP6V1E2
GeneID	90423	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=90423
GeneTree	ENSGT00390000002730	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002730
HAMAP	MF_00311	http://hamap.expasy.org/unirule/MF_00311
HGNC	HGNC:18125	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18125
HOGENOM	HOG000202506	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202506&db=HOGENOM6
HOVERGEN	HBG002309	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG002309&db=HOVERGEN
HPA	HPA052784	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA052784
InParanoid	Q96A05	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96A05
IntAct	Q96A05	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96A05*
InterPro	IPR002842	http://www.ebi.ac.uk/interpro/entry/IPR002842
Jabion	90423	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=90423
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:90423	http://www.genome.jp/dbget-bin/www_bget?hsa:90423
KEGG_Orthology	KO:K02150	http://www.genome.jp/dbget-bin/www_bget?KO:K02150
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04966	http://www.genome.jp/kegg-bin/show_pathway?ko04966
KEGG_Pathway	ko05110	http://www.genome.jp/kegg-bin/show_pathway?ko05110
KEGG_Pathway	ko05120	http://www.genome.jp/kegg-bin/show_pathway?ko05120
KEGG_Pathway	ko05323	http://www.genome.jp/kegg-bin/show_pathway?ko05323
OMA	RNDLISD	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RNDLISD
OrthoDB	EOG091G0OGO	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0OGO
PSORT	swissprot:VATE2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VATE2_HUMAN
PSORT-B	swissprot:VATE2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VATE2_HUMAN
PSORT2	swissprot:VATE2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VATE2_HUMAN
Pfam	PF01991	http://pfam.xfam.org/family/PF01991
PharmGKB	PA25159	http://www.pharmgkb.org/do/serve?objId=PA25159&objCls=Gene
Phobius	swissprot:VATE2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VATE2_HUMAN
PhylomeDB	Q96A05	http://phylomedb.org/?seqid=Q96A05
ProteinModelPortal	Q96A05	http://www.proteinmodelportal.org/query/uniprot/Q96A05
PubMed	12036578	http://www.ncbi.nlm.nih.gov/pubmed/12036578
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
Reactome	R-HSA-1222556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1222556
Reactome	R-HSA-77387	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-77387
Reactome	R-HSA-917977	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917977
Reactome	R-HSA-983712	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983712
RefSeq	NP_001304992	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001304992
RefSeq	XP_005264690	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005264690
RefSeq	XP_005264691	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005264691
RefSeq	XP_011531450	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011531450
RefSeq	XP_011531451	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011531451
RefSeq	XP_011531452	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011531452
RefSeq	XP_011531453	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011531453
RefSeq	XP_011531454	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011531454
RefSeq	XP_011531455	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011531455
RefSeq	XP_016860714	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016860714
RefSeq	XP_016860715	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016860715
SMR	Q96A05	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q96A05
STRING	9606.ENSP00000304891	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000304891&targetmode=cogs
STRING	COG1390	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1390&targetmode=cogs
UCSC	uc002ruy	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ruy&org=rat
UniGene	Hs.659656	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.659656
UniProtKB	VATE2_HUMAN	http://www.uniprot.org/uniprot/VATE2_HUMAN
UniProtKB-AC	Q96A05	http://www.uniprot.org/uniprot/Q96A05
charge	swissprot:VATE2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VATE2_HUMAN
eggNOG	COG1390	http://eggnogapi.embl.de/nog_data/html/tree/COG1390
eggNOG	KOG1664	http://eggnogapi.embl.de/nog_data/html/tree/KOG1664
epestfind	swissprot:VATE2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VATE2_HUMAN
garnier	swissprot:VATE2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VATE2_HUMAN
helixturnhelix	swissprot:VATE2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VATE2_HUMAN
hmoment	swissprot:VATE2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VATE2_HUMAN
iep	swissprot:VATE2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VATE2_HUMAN
inforesidue	swissprot:VATE2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VATE2_HUMAN
neXtProt	NX_Q96A05	http://www.nextprot.org/db/entry/NX_Q96A05
octanol	swissprot:VATE2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VATE2_HUMAN
pepcoil	swissprot:VATE2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VATE2_HUMAN
pepdigest	swissprot:VATE2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VATE2_HUMAN
pepinfo	swissprot:VATE2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VATE2_HUMAN
pepnet	swissprot:VATE2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VATE2_HUMAN
pepstats	swissprot:VATE2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VATE2_HUMAN
pepwheel	swissprot:VATE2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VATE2_HUMAN
pepwindow	swissprot:VATE2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VATE2_HUMAN
sigcleave	swissprot:VATE2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VATE2_HUMAN
## Database	ID	URL or Descriptions
# AltName	AQP6_HUMAN	Aquaporin-2-like
# AltName	AQP6_HUMAN	Kidney-specific aquaporin
# CDD	cd00333	MIP
# DOMAIN	AQP6_HUMAN	Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). 
# Ensembl	ENST00000315520	ENSP00000320247; ENSG00000086159
# Ensembl	ENST00000615425	ENSP00000477688; ENSG00000086159
# ExpressionAtlas	Q13520	baseline and differential
# FUNCTION	AQP6_HUMAN	Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism. {ECO 0000250}. 
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016324	apical plasma membrane; IBA:GO_Central.
# GO_component	GO:0030658	transport vesicle membrane; TAS:Reactome.
# GO_function	GO:0005253	anion channel activity; EXP:Reactome.
# GO_function	GO:0015112	nitrate transmembrane transporter activity; IEA:Ensembl.
# GO_function	GO:0015250	water channel activity; TAS:ProtInc.
# GO_function	GO:0015254	glycerol channel activity; IBA:GO_Central.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006833	water transport; TAS:Reactome.
# GO_process	GO:0007588	excretion; TAS:ProtInc.
# GO_process	GO:0009992	cellular water homeostasis; IBA:GO_Central.
# GO_process	GO:0042476	odontogenesis; IEP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# Gene3D	1.20.1080.10	-; 1.
# Genevisible	Q13520	HS
# HGNC	HGNC:639	AQP6
# InterPro	IPR000425	MIP
# InterPro	IPR022357	MIP_CS
# InterPro	IPR023254	Aquaporin_6
# InterPro	IPR023271	Aquaporin-like
# KEGG_Brite	ko04040	Ion channels
# MIM	601383	gene
# Organism	AQP6_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR19139	PTHR19139
# PDB	1S6E	Model; -; A=1-282
# PRINTS	PR00783	MINTRINSICP
# PRINTS	PR02018	AQUAPORIN6
# PROSITE	PS00221	MIP
# Pfam	PF00230	MIP
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-432047	Passive transport by Aquaporins
# RecName	AQP6_HUMAN	Aquaporin-6
# RefSeq	NP_001643	NM_001652.3
# SIMILARITY	Belongs to the MIP/aquaporin (TC 1.A.8) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	AQP6_HUMAN	Cytoplasmic vesicle membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUPFAM	SSF81338	SSF81338
# TCDB	1.A.8.8	the major intrinsic protein (mip) family
# TIGRFAMs	TIGR00861	MIP
# UCSC	uc001rvr	human
# eggNOG	COG0580	LUCA
# eggNOG	KOG0223	Eukaryota
BLAST	swissprot:AQP6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AQP6_HUMAN
BioCyc	ZFISH:ENSG00000086159-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000086159-MONOMER
COXPRESdb	363	http://coxpresdb.jp/data/gene/363.shtml
CleanEx	HS_AQP6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AQP6
DOI	10.1006/geno.1996.0396	http://dx.doi.org/10.1006/geno.1996.0396
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
EMBL	AC025154	http://www.ebi.ac.uk/ena/data/view/AC025154
EMBL	U48408	http://www.ebi.ac.uk/ena/data/view/U48408
Ensembl	ENST00000315520	http://www.ensembl.org/id/ENST00000315520
Ensembl	ENST00000615425	http://www.ensembl.org/id/ENST00000615425
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0030658	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030658
GO_function	GO:0005253	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005253
GO_function	GO:0015112	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015112
GO_function	GO:0015250	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015250
GO_function	GO:0015254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015254
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006833	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006833
GO_process	GO:0007588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007588
GO_process	GO:0009992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009992
GO_process	GO:0042476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042476
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
Gene3D	1.20.1080.10	http://www.cathdb.info/version/latest/superfamily/1.20.1080.10
GeneCards	AQP6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=AQP6
GeneID	363	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=363
GeneTree	ENSGT00760000119223	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119223
HGNC	HGNC:639	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:639
HOGENOM	HOG000288286	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000288286&db=HOGENOM6
HOVERGEN	HBG000312	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000312&db=HOVERGEN
HPA	HPA015278	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA015278
InParanoid	Q13520	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q13520
InterPro	IPR000425	http://www.ebi.ac.uk/interpro/entry/IPR000425
InterPro	IPR022357	http://www.ebi.ac.uk/interpro/entry/IPR022357
InterPro	IPR023254	http://www.ebi.ac.uk/interpro/entry/IPR023254
InterPro	IPR023271	http://www.ebi.ac.uk/interpro/entry/IPR023271
Jabion	363	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=363
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:363	http://www.genome.jp/dbget-bin/www_bget?hsa:363
KEGG_Orthology	KO:K09868	http://www.genome.jp/dbget-bin/www_bget?KO:K09868
MIM	601383	http://www.ncbi.nlm.nih.gov/omim/601383
OMA	NSVSIGQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NSVSIGQ
OrthoDB	EOG091G166T	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G166T
PANTHER	PTHR19139	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19139
PDB	1S6E	http://www.ebi.ac.uk/pdbe-srv/view/entry/1S6E
PDBsum	1S6E	http://www.ebi.ac.uk/pdbsum/1S6E
PRINTS	PR00783	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00783
PRINTS	PR02018	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR02018
PROSITE	PS00221	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00221
PSORT	swissprot:AQP6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AQP6_HUMAN
PSORT-B	swissprot:AQP6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AQP6_HUMAN
PSORT2	swissprot:AQP6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AQP6_HUMAN
Pfam	PF00230	http://pfam.xfam.org/family/PF00230
PharmGKB	PA24924	http://www.pharmgkb.org/do/serve?objId=PA24924&objCls=Gene
Phobius	swissprot:AQP6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AQP6_HUMAN
PhylomeDB	Q13520	http://phylomedb.org/?seqid=Q13520
ProteinModelPortal	Q13520	http://www.proteinmodelportal.org/query/uniprot/Q13520
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	8812490	http://www.ncbi.nlm.nih.gov/pubmed/8812490
Reactome	R-HSA-432047	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432047
RefSeq	NP_001643	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001643
STRING	9606.ENSP00000320247	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000320247&targetmode=cogs
SUPFAM	SSF81338	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81338
TCDB	1.A.8.8	http://www.tcdb.org/search/result.php?tc=1.A.8.8
TIGRFAMs	TIGR00861	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00861
UCSC	uc001rvr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001rvr&org=rat
UniGene	Hs.54505	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.54505
UniProtKB	AQP6_HUMAN	http://www.uniprot.org/uniprot/AQP6_HUMAN
UniProtKB-AC	Q13520	http://www.uniprot.org/uniprot/Q13520
charge	swissprot:AQP6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AQP6_HUMAN
eggNOG	COG0580	http://eggnogapi.embl.de/nog_data/html/tree/COG0580
eggNOG	KOG0223	http://eggnogapi.embl.de/nog_data/html/tree/KOG0223
epestfind	swissprot:AQP6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AQP6_HUMAN
garnier	swissprot:AQP6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AQP6_HUMAN
helixturnhelix	swissprot:AQP6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AQP6_HUMAN
hmoment	swissprot:AQP6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AQP6_HUMAN
iep	swissprot:AQP6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AQP6_HUMAN
inforesidue	swissprot:AQP6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AQP6_HUMAN
neXtProt	NX_Q13520	http://www.nextprot.org/db/entry/NX_Q13520
octanol	swissprot:AQP6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AQP6_HUMAN
pepcoil	swissprot:AQP6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AQP6_HUMAN
pepdigest	swissprot:AQP6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AQP6_HUMAN
pepinfo	swissprot:AQP6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AQP6_HUMAN
pepnet	swissprot:AQP6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AQP6_HUMAN
pepstats	swissprot:AQP6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AQP6_HUMAN
pepwheel	swissprot:AQP6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AQP6_HUMAN
pepwindow	swissprot:AQP6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AQP6_HUMAN
sigcleave	swissprot:AQP6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AQP6_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	107564	3
# ChiTaRS	CHRNB3	human
# DrugBank	DB00184	Nicotine
# DrugBank	DB00674	Galantamine
# DrugBank	DB00898	Ethanol
# Ensembl	ENST00000289957	ENSP00000289957; ENSG00000147432
# FUNCTION	ACHB3_HUMAN	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005892	acetylcholine-gated channel complex; TAS:ProtInc.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0043005	neuron projection; IEA:Ensembl.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0004889	acetylcholine-activated cation-selective channel activity; TAS:ProtInc.
# GO_function	GO:0008144	drug binding; IEA:Ensembl.
# GO_function	GO:0015267	channel activity; TAS:ProtInc.
# GO_function	GO:0015276	ligand-gated ion channel activity; TAS:Reactome.
# GO_function	GO:0042166	acetylcholine binding; IEA:Ensembl.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0007271	synaptic transmission, cholinergic; TAS:ProtInc.
# GO_process	GO:0007274	neuromuscular synaptic transmission; IBA:GO_Central.
# GO_process	GO:0035094	response to nicotine; IBA:GO_Central.
# GO_process	GO:0051291	protein heterooligomerization; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.20.120.370	-; 2.
# Gene3D	2.70.170.10	-; 1.
# Genevisible	Q05901	HS
# HGNC	HGNC:1963	CHRNB3
# InterPro	IPR002394	Nicotinic_acetylcholine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# InterPro	IPR027361	Acetylcholine_rcpt_TM
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# MIM	118508	gene
# Organism	ACHB3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR18945	PTHR18945
# PIR	I38056	I38056
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00254	NICOTINICR
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb; 2
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-629594	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
# Reactome	R-HSA-629597	Highly calcium permeable nicotinic acetylcholine receptors
# RecName	ACHB3_HUMAN	Neuronal acetylcholine receptor subunit beta-3
# RefSeq	NP_000740	NM_000749.3
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta- 3/CHRNB3 sub-subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	ACHB3_HUMAN	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Neuronal AChR seems to be composed of two different type of subunits	 alpha and beta. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TIGRFAMs	TIGR00860	LIC
# UCSC	uc003xpi	human
# eggNOG	ENOG410XQGR	LUCA
# eggNOG	KOG3645	Eukaryota
BLAST	swissprot:ACHB3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ACHB3_HUMAN
BioCyc	ZFISH:ENSG00000147432-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000147432-MONOMER
COXPRESdb	1142	http://coxpresdb.jp/data/gene/1142.shtml
CleanEx	HS_CHRNB3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CHRNB3
DOI	10.1007/BF02736842	http://dx.doi.org/10.1007/BF02736842
DOI	10.1016/0304-3940(93)90691-D	http://dx.doi.org/10.1016/0304-3940(93)90691-D
DOI	10.1016/S0014-5793(96)01383-X	http://dx.doi.org/10.1016/S0014-5793(96)01383-X
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00184	http://www.drugbank.ca/drugs/DB00184
DrugBank	DB00674	http://www.drugbank.ca/drugs/DB00674
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
EMBL	AF140760	http://www.ebi.ac.uk/ena/data/view/AF140760
EMBL	AF140761	http://www.ebi.ac.uk/ena/data/view/AF140761
EMBL	AF140762	http://www.ebi.ac.uk/ena/data/view/AF140762
EMBL	AF140763	http://www.ebi.ac.uk/ena/data/view/AF140763
EMBL	AF140764	http://www.ebi.ac.uk/ena/data/view/AF140764
EMBL	AF140765	http://www.ebi.ac.uk/ena/data/view/AF140765
EMBL	BC069681	http://www.ebi.ac.uk/ena/data/view/BC069681
EMBL	BC069703	http://www.ebi.ac.uk/ena/data/view/BC069703
EMBL	BC069788	http://www.ebi.ac.uk/ena/data/view/BC069788
EMBL	U62438	http://www.ebi.ac.uk/ena/data/view/U62438
EMBL	X67513	http://www.ebi.ac.uk/ena/data/view/X67513
EMBL	Y08417	http://www.ebi.ac.uk/ena/data/view/Y08417
Ensembl	ENST00000289957	http://www.ensembl.org/id/ENST00000289957
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005892	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005892
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0043005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043005
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0004889	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004889
GO_function	GO:0008144	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008144
GO_function	GO:0015267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015267
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_function	GO:0042166	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042166
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007271
GO_process	GO:0007274	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007274
GO_process	GO:0035094	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035094
GO_process	GO:0051291	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051291
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.20.120.370	http://www.cathdb.info/version/latest/superfamily/1.20.120.370
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	CHRNB3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CHRNB3
GeneID	1142	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1142
GeneTree	ENSGT00760000118930	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118930
HGNC	HGNC:1963	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1963
HOGENOM	HOG000006756	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006756&db=HOGENOM6
HOVERGEN	HBG003756	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003756&db=HOVERGEN
HPA	HPA045555	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA045555
InParanoid	Q05901	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q05901
InterPro	IPR002394	http://www.ebi.ac.uk/interpro/entry/IPR002394
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
InterPro	IPR027361	http://www.ebi.ac.uk/interpro/entry/IPR027361
Jabion	1142	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1142
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:1142	http://www.genome.jp/dbget-bin/www_bget?hsa:1142
KEGG_Orthology	KO:K04814	http://www.genome.jp/dbget-bin/www_bget?KO:K04814
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
MIM	118508	http://www.ncbi.nlm.nih.gov/omim/118508
OMA	DHKLSWN	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DHKLSWN
OrthoDB	EOG091G0R20	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0R20
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00254	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00254
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:ACHB3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ACHB3_HUMAN
PSORT-B	swissprot:ACHB3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ACHB3_HUMAN
PSORT2	swissprot:ACHB3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ACHB3_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA26495	http://www.pharmgkb.org/do/serve?objId=PA26495&objCls=Gene
Phobius	swissprot:ACHB3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ACHB3_HUMAN
PhylomeDB	Q05901	http://phylomedb.org/?seqid=Q05901
ProteinModelPortal	Q05901	http://www.proteinmodelportal.org/query/uniprot/Q05901
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	7690916	http://www.ncbi.nlm.nih.gov/pubmed/7690916
PubMed	8906617	http://www.ncbi.nlm.nih.gov/pubmed/8906617
PubMed	9009220	http://www.ncbi.nlm.nih.gov/pubmed/9009220
Reactome	R-HSA-629594	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-629594
Reactome	R-HSA-629597	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-629597
RefSeq	NP_000740	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000740
STRING	9606.ENSP00000289957	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000289957&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc003xpi	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003xpi&org=rat
UniGene	Hs.654576	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.654576
UniProtKB	ACHB3_HUMAN	http://www.uniprot.org/uniprot/ACHB3_HUMAN
UniProtKB-AC	Q05901	http://www.uniprot.org/uniprot/Q05901
charge	swissprot:ACHB3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ACHB3_HUMAN
eggNOG	ENOG410XQGR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQGR
eggNOG	KOG3645	http://eggnogapi.embl.de/nog_data/html/tree/KOG3645
epestfind	swissprot:ACHB3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ACHB3_HUMAN
garnier	swissprot:ACHB3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ACHB3_HUMAN
helixturnhelix	swissprot:ACHB3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACHB3_HUMAN
hmoment	swissprot:ACHB3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ACHB3_HUMAN
iep	swissprot:ACHB3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ACHB3_HUMAN
inforesidue	swissprot:ACHB3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ACHB3_HUMAN
neXtProt	NX_Q05901	http://www.nextprot.org/db/entry/NX_Q05901
octanol	swissprot:ACHB3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ACHB3_HUMAN
pepcoil	swissprot:ACHB3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ACHB3_HUMAN
pepdigest	swissprot:ACHB3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ACHB3_HUMAN
pepinfo	swissprot:ACHB3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ACHB3_HUMAN
pepnet	swissprot:ACHB3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ACHB3_HUMAN
pepstats	swissprot:ACHB3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ACHB3_HUMAN
pepwheel	swissprot:ACHB3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ACHB3_HUMAN
pepwindow	swissprot:ACHB3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ACHB3_HUMAN
sigcleave	swissprot:ACHB3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ACHB3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GBRE_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P78334-1; Sequence=Displayed; Name=2; IsoId=P78334-2; Sequence=VSP_055776, VSP_055777; Note=No experimental confirmation available.; 
# AltName	GBRE_HUMAN	GABA(A) receptor subunit epsilon
# BioGrid	108838	42
# CCDS	CCDS14703	-. [P78334-1]
# ChiTaRS	GABRE	human
# DrugBank	DB00186	Lorazepam
# DrugBank	DB00189	Ethchlorvynol
# DrugBank	DB00228	Enflurane
# DrugBank	DB00231	Temazepam
# DrugBank	DB00237	Butabarbital
# DrugBank	DB00241	Butalbital
# DrugBank	DB00273	Topiramate
# DrugBank	DB00292	Etomidate
# DrugBank	DB00306	Talbutal
# DrugBank	DB00312	Pentobarbital
# DrugBank	DB00334	Olanzapine
# DrugBank	DB00349	Clobazam
# DrugBank	DB00371	Meprobamate
# DrugBank	DB00402	Eszopiclone
# DrugBank	DB00404	Alprazolam
# DrugBank	DB00475	Chlordiazepoxide
# DrugBank	DB00543	Amoxapine
# DrugBank	DB00546	Adinazolam
# DrugBank	DB00628	Clorazepate
# DrugBank	DB00659	Acamprosate
# DrugBank	DB00683	Midazolam
# DrugBank	DB00690	Flurazepam
# DrugBank	DB00753	Isoflurane
# DrugBank	DB00794	Primidone
# DrugBank	DB00801	Halazepam
# DrugBank	DB00818	Propofol
# DrugBank	DB00829	Diazepam
# DrugBank	DB00842	Oxazepam
# DrugBank	DB00897	Triazolam
# DrugBank	DB00898	Ethanol
# DrugBank	DB01028	Methoxyflurane
# DrugBank	DB01049	Ergoloid mesylate
# DrugBank	DB01068	Clonazepam
# DrugBank	DB01107	Methyprylon
# DrugBank	DB01159	Halothane
# DrugBank	DB01189	Desflurane
# DrugBank	DB01205	Flumazenil
# DrugBank	DB01215	Estazolam
# DrugBank	DB01236	Sevoflurane
# DrugBank	DB01437	Glutethimide
# DrugBank	DB01558	Bromazepam
# DrugBank	DB01559	Clotiazepam
# DrugBank	DB01567	Fludiazepam
# DrugBank	DB01587	Ketazolam
# DrugBank	DB01588	Prazepam
# DrugBank	DB01589	Quazepam
# DrugBank	DB01594	Cinolazepam
# DrugBank	DB01595	Nitrazepam
# Ensembl	ENST00000370328	ENSP00000359353; ENSG00000102287. [P78334-1]
# ExpressionAtlas	P78334	baseline and differential
# FUNCTION	GBRE_HUMAN	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. 
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:1902711	GABA-A receptor complex; IDA:GO_Central.
# GO_function	GO:0004890	GABA-A receptor activity; IEA:InterPro.
# GO_function	GO:0022851	GABA-gated chloride ion channel activity; IDA:GO_Central.
# GO_process	GO:2001226	negative regulation of chloride transport; IDA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# Gene3D	2.70.170.10	-; 1.
# Genevisible	P78334	HS
# HGNC	HGNC:4085	GABRE
# InterPro	IPR006028	GABAA/Glycine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR008099	GABAAe_rcpt
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04727	GABAergic synapse
# KEGG_Pathway	ko05032	Morphine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# MIM	300093	gene
# Organism	GBRE_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR18945	PTHR18945; 2
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00253	GABAARECEPTR
# PRINTS	PR01723	GABAAREPSLON
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome X
# RecName	GBRE_HUMAN	Gamma-aminobutyric acid receptor subunit epsilon
# RefSeq	NP_004952	NM_004961.3. [P78334-1]
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRE sub-subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	GBRE_HUMAN	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	GBRE_HUMAN	Generally pentameric. Associates with alpha and beta subunits. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112; 2
# TIGRFAMs	TIGR00860	LIC
# TISSUE SPECIFICITY	GBRE_HUMAN	Expressed in many tissues. Highest levels of expression in adult heart and placenta. 
# UCSC	uc004ffi	human. [P78334-1]
# eggNOG	ENOG410XNQG	LUCA
# eggNOG	KOG3642	Eukaryota
BLAST	swissprot:GBRE_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GBRE_HUMAN
BioCyc	ZFISH:ENSG00000102287-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000102287-MONOMER
COXPRESdb	2564	http://coxpresdb.jp/data/gene/2564.shtml
CleanEx	HS_GABRE	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GABRE
DOI	10.1006/geno.1997.4885	http://dx.doi.org/10.1006/geno.1997.4885
DOI	10.1038/385820a0	http://dx.doi.org/10.1038/385820a0
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00186	http://www.drugbank.ca/drugs/DB00186
DrugBank	DB00189	http://www.drugbank.ca/drugs/DB00189
DrugBank	DB00228	http://www.drugbank.ca/drugs/DB00228
DrugBank	DB00231	http://www.drugbank.ca/drugs/DB00231
DrugBank	DB00237	http://www.drugbank.ca/drugs/DB00237
DrugBank	DB00241	http://www.drugbank.ca/drugs/DB00241
DrugBank	DB00273	http://www.drugbank.ca/drugs/DB00273
DrugBank	DB00292	http://www.drugbank.ca/drugs/DB00292
DrugBank	DB00306	http://www.drugbank.ca/drugs/DB00306
DrugBank	DB00312	http://www.drugbank.ca/drugs/DB00312
DrugBank	DB00334	http://www.drugbank.ca/drugs/DB00334
DrugBank	DB00349	http://www.drugbank.ca/drugs/DB00349
DrugBank	DB00371	http://www.drugbank.ca/drugs/DB00371
DrugBank	DB00402	http://www.drugbank.ca/drugs/DB00402
DrugBank	DB00404	http://www.drugbank.ca/drugs/DB00404
DrugBank	DB00475	http://www.drugbank.ca/drugs/DB00475
DrugBank	DB00543	http://www.drugbank.ca/drugs/DB00543
DrugBank	DB00546	http://www.drugbank.ca/drugs/DB00546
DrugBank	DB00628	http://www.drugbank.ca/drugs/DB00628
DrugBank	DB00659	http://www.drugbank.ca/drugs/DB00659
DrugBank	DB00683	http://www.drugbank.ca/drugs/DB00683
DrugBank	DB00690	http://www.drugbank.ca/drugs/DB00690
DrugBank	DB00753	http://www.drugbank.ca/drugs/DB00753
DrugBank	DB00794	http://www.drugbank.ca/drugs/DB00794
DrugBank	DB00801	http://www.drugbank.ca/drugs/DB00801
DrugBank	DB00818	http://www.drugbank.ca/drugs/DB00818
DrugBank	DB00829	http://www.drugbank.ca/drugs/DB00829
DrugBank	DB00842	http://www.drugbank.ca/drugs/DB00842
DrugBank	DB00897	http://www.drugbank.ca/drugs/DB00897
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01028	http://www.drugbank.ca/drugs/DB01028
DrugBank	DB01049	http://www.drugbank.ca/drugs/DB01049
DrugBank	DB01068	http://www.drugbank.ca/drugs/DB01068
DrugBank	DB01107	http://www.drugbank.ca/drugs/DB01107
DrugBank	DB01159	http://www.drugbank.ca/drugs/DB01159
DrugBank	DB01189	http://www.drugbank.ca/drugs/DB01189
DrugBank	DB01205	http://www.drugbank.ca/drugs/DB01205
DrugBank	DB01215	http://www.drugbank.ca/drugs/DB01215
DrugBank	DB01236	http://www.drugbank.ca/drugs/DB01236
DrugBank	DB01437	http://www.drugbank.ca/drugs/DB01437
DrugBank	DB01558	http://www.drugbank.ca/drugs/DB01558
DrugBank	DB01559	http://www.drugbank.ca/drugs/DB01559
DrugBank	DB01567	http://www.drugbank.ca/drugs/DB01567
DrugBank	DB01587	http://www.drugbank.ca/drugs/DB01587
DrugBank	DB01588	http://www.drugbank.ca/drugs/DB01588
DrugBank	DB01589	http://www.drugbank.ca/drugs/DB01589
DrugBank	DB01594	http://www.drugbank.ca/drugs/DB01594
DrugBank	DB01595	http://www.drugbank.ca/drugs/DB01595
EMBL	AF274855	http://www.ebi.ac.uk/ena/data/view/AF274855
EMBL	BC026337	http://www.ebi.ac.uk/ena/data/view/BC026337
EMBL	BC047108	http://www.ebi.ac.uk/ena/data/view/BC047108
EMBL	BC059376	http://www.ebi.ac.uk/ena/data/view/BC059376
EMBL	U66661	http://www.ebi.ac.uk/ena/data/view/U66661
EMBL	U92281	http://www.ebi.ac.uk/ena/data/view/U92281
EMBL	U92282	http://www.ebi.ac.uk/ena/data/view/U92282
EMBL	U92283	http://www.ebi.ac.uk/ena/data/view/U92283
EMBL	Y07637	http://www.ebi.ac.uk/ena/data/view/Y07637
EMBL	Y09763	http://www.ebi.ac.uk/ena/data/view/Y09763
EMBL	Y09764	http://www.ebi.ac.uk/ena/data/view/Y09764
EMBL	Y09765	http://www.ebi.ac.uk/ena/data/view/Y09765
Ensembl	ENST00000370328	http://www.ensembl.org/id/ENST00000370328
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_component	GO:1902711	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902711
GO_function	GO:0004890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004890
GO_function	GO:0022851	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022851
GO_process	GO:2001226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001226
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	GABRE	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GABRE
GeneID	2564	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2564
GeneTree	ENSGT00760000119010	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119010
HGNC	HGNC:4085	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4085
HOGENOM	HOG000231337	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231337&db=HOGENOM6
HOVERGEN	HBG051707	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051707&db=HOVERGEN
HPA	HPA045918	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA045918
InParanoid	P78334	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P78334
InterPro	IPR006028	http://www.ebi.ac.uk/interpro/entry/IPR006028
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR008099	http://www.ebi.ac.uk/interpro/entry/IPR008099
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
Jabion	2564	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2564
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:2564	http://www.genome.jp/dbget-bin/www_bget?hsa:2564
KEGG_Orthology	KO:K05185	http://www.genome.jp/dbget-bin/www_bget?KO:K05185
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
KEGG_Pathway	ko05032	http://www.genome.jp/kegg-bin/show_pathway?ko05032
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
MIM	300093	http://www.ncbi.nlm.nih.gov/omim/300093
OMA	CALMEFA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CALMEFA
OrthoDB	EOG091G0805	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0805
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00253	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00253
PRINTS	PR01723	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01723
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:GBRE_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GBRE_HUMAN
PSORT-B	swissprot:GBRE_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GBRE_HUMAN
PSORT2	swissprot:GBRE_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GBRE_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA28499	http://www.pharmgkb.org/do/serve?objId=PA28499&objCls=Gene
Phobius	swissprot:GBRE_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GBRE_HUMAN
PhylomeDB	P78334	http://phylomedb.org/?seqid=P78334
ProteinModelPortal	P78334	http://www.proteinmodelportal.org/query/uniprot/P78334
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	9039914	http://www.ncbi.nlm.nih.gov/pubmed/9039914
PubMed	9084408	http://www.ncbi.nlm.nih.gov/pubmed/9084408
PubMed	9339354	http://www.ncbi.nlm.nih.gov/pubmed/9339354
RefSeq	NP_004952	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004952
SMR	P78334	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P78334
STRING	9606.ENSP00000359353	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000359353&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc004ffi	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004ffi&org=rat
UniGene	Hs.22785	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.22785
UniProtKB	GBRE_HUMAN	http://www.uniprot.org/uniprot/GBRE_HUMAN
UniProtKB-AC	P78334	http://www.uniprot.org/uniprot/P78334
charge	swissprot:GBRE_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GBRE_HUMAN
eggNOG	ENOG410XNQG	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNQG
eggNOG	KOG3642	http://eggnogapi.embl.de/nog_data/html/tree/KOG3642
epestfind	swissprot:GBRE_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GBRE_HUMAN
garnier	swissprot:GBRE_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GBRE_HUMAN
helixturnhelix	swissprot:GBRE_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GBRE_HUMAN
hmoment	swissprot:GBRE_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GBRE_HUMAN
iep	swissprot:GBRE_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GBRE_HUMAN
inforesidue	swissprot:GBRE_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GBRE_HUMAN
neXtProt	NX_P78334	http://www.nextprot.org/db/entry/NX_P78334
octanol	swissprot:GBRE_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GBRE_HUMAN
pepcoil	swissprot:GBRE_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GBRE_HUMAN
pepdigest	swissprot:GBRE_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GBRE_HUMAN
pepinfo	swissprot:GBRE_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GBRE_HUMAN
pepnet	swissprot:GBRE_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GBRE_HUMAN
pepstats	swissprot:GBRE_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GBRE_HUMAN
pepwheel	swissprot:GBRE_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GBRE_HUMAN
pepwindow	swissprot:GBRE_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GBRE_HUMAN
sigcleave	swissprot:GBRE_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GBRE_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCA10_HUMAN	Voltage-gated potassium channel subunit Kv1.8
# BioGrid	109946	17
# DOMAIN	KCA10_HUMAN	The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. 
# DOMAIN	KCA10_HUMAN	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. 
# DrugBank	DB06637	Dalfampridine
# Ensembl	ENST00000369771	ENSP00000358786; ENSG00000143105
# FUNCTION	KCA10_HUMAN	Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP. {ECO 0000269|PubMed 10836990}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IEA:InterPro.
# GO_component	GO:0016021	integral component of membrane; IBA:GO_Central.
# GO_function	GO:0005221	intracellular cyclic nucleotide activated cation channel activity; TAS:ProtInc.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; IBA:GO_Central.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0051260	protein homooligomerization; IEA:InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# Gene3D	1.20.120.350	-; 1.
# Genevisible	Q16322	HS
# HGNC	HGNC:6219	KCNA10
# InterPro	IPR000210	BTB/POZ_dom
# InterPro	IPR003131	T1-type_BTB
# InterPro	IPR003968	K_chnl_volt-dep_Kv
# InterPro	IPR003972	K_chnl_volt-dep_Kv1
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR011333	SKP1/BTB/POZ
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko04040	Ion channels
# MIM	602420	gene
# Organism	KCA10_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11537	PTHR11537
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01491	KVCHANNEL
# PRINTS	PR01496	SHAKERCHANEL
# Pfam	PF00520	Ion_trans
# Pfam	PF02214	BTB_2
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# RecName	KCA10_HUMAN	Potassium voltage-gated channel subfamily A member 10
# RefSeq	NP_005540	NM_005549.2
# SIMILARITY	Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.8/KCNA10 sub-subfamily. {ECO	0000305}.
# SMART	SM00225	BTB
# SUBCELLULAR LOCATION	KCA10_HUMAN	Membrane {ECO 0000269|PubMed 10836990}; Multi-pass membrane protein {ECO 0000269|PubMed 10836990}. 
# SUBUNIT	Homotetramer. Interacts with KCN4B/POMP. Interaction with KCN4B/POMP is necessary for the modulation of channel activity by cAMP. {ECO:0000269|PubMed	12060596}. 
# SUPFAM	SSF54695	SSF54695
# TISSUE SPECIFICITY	Detected in kidney, in proximal tubules, glomerular endothelium, in vascular endothelium and in smooth muscle cells. {ECO:0000269|PubMed	12444201}. 
# UCSC	uc001dzt	human
# eggNOG	COG1226	LUCA
# eggNOG	KOG1545	Eukaryota
BLAST	swissprot:KCA10_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCA10_HUMAN
BioCyc	ZFISH:ENSG00000143105-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000143105-MONOMER
COXPRESdb	3744	http://coxpresdb.jp/data/gene/3744.shtml
CleanEx	HS_KCNA10	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNA10
DOI	10.1006/geno.1997.4712	http://dx.doi.org/10.1006/geno.1997.4712
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1097/01.ASN.0000036866.37886.C5	http://dx.doi.org/10.1097/01.ASN.0000036866.37886.C5
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1152/ajprenal.00258.2001	http://dx.doi.org/10.1152/ajprenal.00258.2001
DrugBank	DB06637	http://www.drugbank.ca/drugs/DB06637
EMBL	AL358215	http://www.ebi.ac.uk/ena/data/view/AL358215
EMBL	BC074990	http://www.ebi.ac.uk/ena/data/view/BC074990
EMBL	CH471122	http://www.ebi.ac.uk/ena/data/view/CH471122
EMBL	U96110	http://www.ebi.ac.uk/ena/data/view/U96110
Ensembl	ENST00000369771	http://www.ensembl.org/id/ENST00000369771
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005221	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005221
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	KCNA10	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNA10
GeneID	3744	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3744
GeneTree	ENSGT00760000118846	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118846
H-InvDB	HIX0200074	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0200074
HGNC	HGNC:6219	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6219
HOGENOM	HOG000231015	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231015&db=HOGENOM6
HOVERGEN	HBG052230	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052230&db=HOVERGEN
HPA	CAB022564	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB022564
HPA	HPA015061	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA015061
InParanoid	Q16322	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q16322
IntAct	Q16322	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q16322*
InterPro	IPR000210	http://www.ebi.ac.uk/interpro/entry/IPR000210
InterPro	IPR003131	http://www.ebi.ac.uk/interpro/entry/IPR003131
InterPro	IPR003968	http://www.ebi.ac.uk/interpro/entry/IPR003968
InterPro	IPR003972	http://www.ebi.ac.uk/interpro/entry/IPR003972
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR011333	http://www.ebi.ac.uk/interpro/entry/IPR011333
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	3744	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3744
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3744	http://www.genome.jp/dbget-bin/www_bget?hsa:3744
KEGG_Orthology	KO:K04881	http://www.genome.jp/dbget-bin/www_bget?KO:K04881
MIM	602420	http://www.ncbi.nlm.nih.gov/omim/602420
OMA	QNIPGEI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QNIPGEI
OrthoDB	EOG091G10NU	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G10NU
PANTHER	PTHR11537	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01491	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01491
PRINTS	PR01496	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01496
PSORT	swissprot:KCA10_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCA10_HUMAN
PSORT-B	swissprot:KCA10_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCA10_HUMAN
PSORT2	swissprot:KCA10_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCA10_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF02214	http://pfam.xfam.org/family/PF02214
PharmGKB	PA30020	http://www.pharmgkb.org/do/serve?objId=PA30020&objCls=Gene
Phobius	swissprot:KCA10_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCA10_HUMAN
PhylomeDB	Q16322	http://phylomedb.org/?seqid=Q16322
ProteinModelPortal	Q16322	http://www.proteinmodelportal.org/query/uniprot/Q16322
PubMed	10836990	http://www.ncbi.nlm.nih.gov/pubmed/10836990
PubMed	12060596	http://www.ncbi.nlm.nih.gov/pubmed/12060596
PubMed	12444201	http://www.ncbi.nlm.nih.gov/pubmed/12444201
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	9177773	http://www.ncbi.nlm.nih.gov/pubmed/9177773
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
RefSeq	NP_005540	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005540
SMART	SM00225	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225
SMR	Q16322	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q16322
STRING	9606.ENSP00000358786	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000358786&targetmode=cogs
SUPFAM	SSF54695	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54695
UCSC	uc001dzt	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001dzt&org=rat
UniGene	Hs.248140	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.248140
UniGene	Hs.622910	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.622910
UniProtKB	KCA10_HUMAN	http://www.uniprot.org/uniprot/KCA10_HUMAN
UniProtKB-AC	Q16322	http://www.uniprot.org/uniprot/Q16322
charge	swissprot:KCA10_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCA10_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG1545	http://eggnogapi.embl.de/nog_data/html/tree/KOG1545
epestfind	swissprot:KCA10_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCA10_HUMAN
garnier	swissprot:KCA10_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCA10_HUMAN
helixturnhelix	swissprot:KCA10_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCA10_HUMAN
hmoment	swissprot:KCA10_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCA10_HUMAN
iep	swissprot:KCA10_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCA10_HUMAN
inforesidue	swissprot:KCA10_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCA10_HUMAN
neXtProt	NX_Q16322	http://www.nextprot.org/db/entry/NX_Q16322
octanol	swissprot:KCA10_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCA10_HUMAN
pepcoil	swissprot:KCA10_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCA10_HUMAN
pepdigest	swissprot:KCA10_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCA10_HUMAN
pepinfo	swissprot:KCA10_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCA10_HUMAN
pepnet	swissprot:KCA10_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCA10_HUMAN
pepstats	swissprot:KCA10_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCA10_HUMAN
pepwheel	swissprot:KCA10_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCA10_HUMAN
pepwindow	swissprot:KCA10_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCA10_HUMAN
sigcleave	swissprot:KCA10_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCA10_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	MFRN2_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q96A46-1; Sequence=Displayed; Name=2; IsoId=Q96A46-2; Sequence=VSP_018414; Name=3; IsoId=Q96A46-3; Sequence=VSP_018413, VSP_018415; 
# AltName	MFRN2_HUMAN	Mitochondrial RNA-splicing protein 3/4 homolog
# AltName	MFRN2_HUMAN	Mitochondrial iron transporter 2
# AltName	MFRN2_HUMAN	Solute carrier family 25 member 28
# BioGrid	123626	3
# CCDS	CCDS41559	-. [Q96A46-1]
# ChiTaRS	SLC25A28	human
# Ensembl	ENST00000370495	ENSP00000359526; ENSG00000155287. [Q96A46-1]
# ExpressionAtlas	Q96A46	baseline and differential
# FUNCTION	MFRN2_HUMAN	Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity). {ECO 0000250}. 
# GO_component	GO:0005743	mitochondrial inner membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015093	ferrous iron transmembrane transporter activity; IEA:Ensembl.
# GO_process	GO:0055072	iron ion homeostasis; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0042592	homeostatic process
# Gene3D	1.50.40.10	-; 1.
# Genevisible	Q96A46	HS
# HGNC	HGNC:23472	SLC25A28
# InterPro	IPR018108	Mitochondrial_sb/sol_carrier
# InterPro	IPR023395	Mt_carrier_dom
# KEGG_Brite	ko02001	Solute carrier family
# MIM	609767	gene
# Organism	MFRN2_HUMAN	Homo sapiens (Human)
# PROSITE	PS50920	SOLCAR; 3
# Pfam	PF00153	Mito_carr; 3
# Proteomes	UP000005640	Chromosome 10
# Reactome	R-HSA-1362409	Mitochondrial iron-sulfur cluster biogenesis
# RecName	MFRN2_HUMAN	Mitoferrin-2
# RefSeq	NP_112489	NM_031212.3. [Q96A46-1]
# SEQUENCE CAUTION	Sequence=AAH47312.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI16900.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the mitochondrial carrier (TC 2.A.29) family. {ECO	0000305}. 
# SIMILARITY	Contains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule	PRU00282}. 
# SUBCELLULAR LOCATION	MFRN2_HUMAN	Mitochondrion inner membrane {ECO 0000269|PubMed 11297739}; Multi-pass membrane protein {ECO 0000269|PubMed 11297739}. Note=Isoform 1 and isoform 2 are both localized in the mitochondrion. 
# SUPFAM	SSF103506	SSF103506
# TCDB	2.A.29.5	the mitochondrial carrier (mc) family
# TISSUE SPECIFICITY	Ubiquitous. Expressed in placenta, lung, kidney, pancreas, liver, brain, skeletal muscle and heart. {ECO:0000269|PubMed	11297739}. 
# UCSC	uc001kpx	human. [Q96A46-1]
# eggNOG	ENOG410XNT2	LUCA
# eggNOG	KOG0760	Eukaryota
BLAST	swissprot:MFRN2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MFRN2_HUMAN
BioCyc	ZFISH:ENSG00000155287-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000155287-MONOMER
COXPRESdb	81894	http://coxpresdb.jp/data/gene/81894.shtml
CleanEx	HS_SLC25A28	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC25A28
DOI	10.1016/S0014-5793(01)02319-5	http://dx.doi.org/10.1016/S0014-5793(01)02319-5
DOI	10.1038/nature02462	http://dx.doi.org/10.1038/nature02462
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AF267854	http://www.ebi.ac.uk/ena/data/view/AF267854
EMBL	AF327402	http://www.ebi.ac.uk/ena/data/view/AF327402
EMBL	AF327403	http://www.ebi.ac.uk/ena/data/view/AF327403
EMBL	AJ303077	http://www.ebi.ac.uk/ena/data/view/AJ303077
EMBL	AJ303078	http://www.ebi.ac.uk/ena/data/view/AJ303078
EMBL	AL353719	http://www.ebi.ac.uk/ena/data/view/AL353719
EMBL	AL353719	http://www.ebi.ac.uk/ena/data/view/AL353719
EMBL	AL831943	http://www.ebi.ac.uk/ena/data/view/AL831943
EMBL	BC047312	http://www.ebi.ac.uk/ena/data/view/BC047312
EMBL	BC058937	http://www.ebi.ac.uk/ena/data/view/BC058937
EMBL	BC076399	http://www.ebi.ac.uk/ena/data/view/BC076399
EMBL	BC094821	http://www.ebi.ac.uk/ena/data/view/BC094821
Ensembl	ENST00000370495	http://www.ensembl.org/id/ENST00000370495
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015093	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015093
GO_process	GO:0055072	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
Gene3D	1.50.40.10	http://www.cathdb.info/version/latest/superfamily/1.50.40.10
GeneCards	SLC25A28	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC25A28
GeneID	81894	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81894
GeneTree	ENSGT00550000074721	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074721
H-InvDB	HIX0009111	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0009111
HGNC	HGNC:23472	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:23472
HOGENOM	HOG000038810	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000038810&db=HOGENOM6
HOVERGEN	HBG079464	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG079464&db=HOVERGEN
InParanoid	Q96A46	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96A46
InterPro	IPR018108	http://www.ebi.ac.uk/interpro/entry/IPR018108
InterPro	IPR023395	http://www.ebi.ac.uk/interpro/entry/IPR023395
Jabion	81894	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=81894
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:81894	http://www.genome.jp/dbget-bin/www_bget?hsa:81894
KEGG_Orthology	KO:K15113	http://www.genome.jp/dbget-bin/www_bget?KO:K15113
MIM	609767	http://www.ncbi.nlm.nih.gov/omim/609767
OMA	PMRGLNI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PMRGLNI
OrthoDB	EOG091G0PU8	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0PU8
PROSITE	PS50920	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50920
PSORT	swissprot:MFRN2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MFRN2_HUMAN
PSORT-B	swissprot:MFRN2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MFRN2_HUMAN
PSORT2	swissprot:MFRN2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MFRN2_HUMAN
Pfam	PF00153	http://pfam.xfam.org/family/PF00153
PharmGKB	PA134867966	http://www.pharmgkb.org/do/serve?objId=PA134867966&objCls=Gene
Phobius	swissprot:MFRN2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MFRN2_HUMAN
PhylomeDB	Q96A46	http://phylomedb.org/?seqid=Q96A46
ProteinModelPortal	Q96A46	http://www.proteinmodelportal.org/query/uniprot/Q96A46
PubMed	11297739	http://www.ncbi.nlm.nih.gov/pubmed/11297739
PubMed	15164054	http://www.ncbi.nlm.nih.gov/pubmed/15164054
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
Reactome	R-HSA-1362409	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1362409
RefSeq	NP_112489	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_112489
SMR	Q96A46	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q96A46
STRING	9606.ENSP00000359526	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000359526&targetmode=cogs
SUPFAM	SSF103506	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103506
TCDB	2.A.29.5	http://www.tcdb.org/search/result.php?tc=2.A.29.5
UCSC	uc001kpx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001kpx&org=rat
UniGene	Hs.403790	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.403790
UniGene	Hs.736801	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.736801
UniProtKB	MFRN2_HUMAN	http://www.uniprot.org/uniprot/MFRN2_HUMAN
UniProtKB-AC	Q96A46	http://www.uniprot.org/uniprot/Q96A46
charge	swissprot:MFRN2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MFRN2_HUMAN
eggNOG	ENOG410XNT2	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNT2
eggNOG	KOG0760	http://eggnogapi.embl.de/nog_data/html/tree/KOG0760
epestfind	swissprot:MFRN2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MFRN2_HUMAN
garnier	swissprot:MFRN2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MFRN2_HUMAN
helixturnhelix	swissprot:MFRN2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MFRN2_HUMAN
hmoment	swissprot:MFRN2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MFRN2_HUMAN
iep	swissprot:MFRN2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MFRN2_HUMAN
inforesidue	swissprot:MFRN2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MFRN2_HUMAN
neXtProt	NX_Q96A46	http://www.nextprot.org/db/entry/NX_Q96A46
octanol	swissprot:MFRN2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MFRN2_HUMAN
pepcoil	swissprot:MFRN2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MFRN2_HUMAN
pepdigest	swissprot:MFRN2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MFRN2_HUMAN
pepinfo	swissprot:MFRN2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MFRN2_HUMAN
pepnet	swissprot:MFRN2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MFRN2_HUMAN
pepstats	swissprot:MFRN2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MFRN2_HUMAN
pepwheel	swissprot:MFRN2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MFRN2_HUMAN
pepwindow	swissprot:MFRN2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MFRN2_HUMAN
sigcleave	swissprot:MFRN2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MFRN2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AP1B1_HUMAN	Event=Alternative splicing; Named isoforms=4; Comment=Additional isoforms seem to exist.; Name=A; IsoId=Q10567-1; Sequence=Displayed; Name=B; IsoId=Q10567-2; Sequence=VSP_000163; Name=C; IsoId=Q10567-3; Sequence=VSP_000163, VSP_038753; Name=4; IsoId=Q10567-4; Sequence=VSP_000163, VSP_044928, VSP_038753; Note=No experimental confirmation available.; 
# AltName	AP1B1_HUMAN	Adaptor protein complex AP-1 subunit beta-1
# AltName	AP1B1_HUMAN	Adaptor-related protein complex 1 subunit beta-1
# AltName	AP1B1_HUMAN	Beta-1-adaptin
# AltName	AP1B1_HUMAN	Beta-adaptin 1
# AltName	AP1B1_HUMAN	Clathrin assembly protein complex 1 beta large chain
# AltName	AP1B1_HUMAN	Golgi adaptor HA1/AP1 adaptin beta subunit
# BioGrid	106671	74
# CCDS	CCDS13855	-. [Q10567-1]
# CCDS	CCDS13856	-. [Q10567-3]
# CCDS	CCDS54515	-. [Q10567-4]
# ChiTaRS	AP1B1	human
# Ensembl	ENST00000317368	ENSP00000319361; ENSG00000100280
# Ensembl	ENST00000357586	ENSP00000350199; ENSG00000100280
# Ensembl	ENST00000402502	ENSP00000386071; ENSG00000100280
# Ensembl	ENST00000405198	ENSP00000384194; ENSG00000100280
# Ensembl	ENST00000415447	ENSP00000387612; ENSG00000100280
# Ensembl	ENST00000432560	ENSP00000400065; ENSG00000100280
# ExpressionAtlas	Q10567	baseline and differential
# FUNCTION	AP1B1_HUMAN	Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. 
# GO_component	GO:0000139	Golgi membrane; TAS:Reactome.
# GO_component	GO:0005765	lysosomal membrane; TAS:Reactome.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0030131	clathrin adaptor complex; IEA:InterPro.
# GO_component	GO:0030659	cytoplasmic vesicle membrane; TAS:Reactome.
# GO_component	GO:0030669	clathrin-coated endocytic vesicle membrane; TAS:Reactome.
# GO_component	GO:0032588	trans-Golgi network membrane; TAS:Reactome.
# GO_function	GO:0005215	transporter activity; TAS:ProtInc.
# GO_function	GO:0008565	protein transporter activity; IEA:InterPro.
# GO_function	GO:0019901	protein kinase binding; ISS:ParkinsonsUK-UCL.
# GO_process	GO:0006886	intracellular protein transport; IEA:InterPro.
# GO_process	GO:0007368	determination of left/right symmetry; IEA:Ensembl.
# GO_process	GO:0007507	heart development; IEA:Ensembl.
# GO_process	GO:0016192	vesicle-mediated transport; IEA:InterPro.
# GO_process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
# GO_process	GO:0050690	regulation of defense response to virus by virus; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0048856	anatomical structure development
# Gene3D	1.25.10.10	-; 1.
# Gene3D	2.60.40.1150	-; 1.
# Gene3D	3.30.310.10	-; 1.
# Genevisible	Q10567	HS
# HGNC	HGNC:554	AP1B1
# INTERACTION	AP1B1_HUMAN	P35585 Ap1m1 (xeno); NbExp=5; IntAct=EBI-1171303, EBI-1040251; 
# IntAct	Q10567	56
# InterPro	IPR000225	Armadillo
# InterPro	IPR002553	Clathrin/coatomer_adapt-like_N
# InterPro	IPR008152	Clathrin_a/b/g-adaptin_app_Ig
# InterPro	IPR009028	Coatomer/calthrin_app_sub_C
# InterPro	IPR011989	ARM-like
# InterPro	IPR012295	Beta2_adaptin/TBP_C_dom
# InterPro	IPR013037	Clathrin_b-adaptin_app_Ig-like
# InterPro	IPR013041	Coatomer/clathrin_app_Ig-like
# InterPro	IPR015151	B-adaptin_app_sub_C
# InterPro	IPR016024	ARM-type_fold
# InterPro	IPR016342	AP_complex_bsu_1_2_4
# InterPro	IPR026739	AP_beta
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Pathway	ko04142	Lysosome
# MIM	600157	gene
# Organism	AP1B1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11134	PTHR11134
# PDB	4HMY	X-ray; 7.00 A; B=1-584
# PDB	4P6Z	X-ray; 3.00 A; B=1-584
# PIR	I54360	I54360
# PIRSF	PIRSF002291	AP_complex_beta
# Pfam	PF01602	Adaptin_N
# Pfam	PF02883	Alpha_adaptinC2
# Pfam	PF09066	B2-adapt-app_C
# Proteomes	UP000005640	Chromosome 22
# Reactome	R-HSA-164940	Nef mediated downregulation of MHC class I complex cell surface expression
# Reactome	R-HSA-2132295	MHC class II antigen presentation
# Reactome	R-HSA-432720	Lysosome Vesicle Biogenesis
# Reactome	R-HSA-432722	Golgi Associated Vesicle Biogenesis
# RecName	AP1B1_HUMAN	AP-1 complex subunit beta-1
# RefSeq	NP_001118	NM_001127.3
# RefSeq	NP_001159491	NM_001166019.1
# RefSeq	NP_663782	NM_145730.2
# SIMILARITY	Belongs to the adaptor complexes large subunit family. {ECO	0000305}.
# SMART	SM00185	ARM; 2
# SMART	SM00809	Alpha_adaptinC2
# SMART	SM01020	B2-adapt-app_C
# SUBCELLULAR LOCATION	AP1B1_HUMAN	Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. 
# SUBUNIT	AP1B1_HUMAN	Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta- type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). 
# SUPFAM	SSF48371	SSF48371
# SUPFAM	SSF49348	SSF49348
# SUPFAM	SSF55711	SSF55711
# TISSUE SPECIFICITY	AP1B1_HUMAN	Widely expressed. 
# UCSC	uc003afi	human. [Q10567-1]
# eggNOG	COG5096	LUCA
# eggNOG	KOG1061	Eukaryota
BLAST	swissprot:AP1B1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AP1B1_HUMAN
BioCyc	ZFISH:ENSG00000100280-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000100280-MONOMER
COXPRESdb	162	http://coxpresdb.jp/data/gene/162.shtml
CleanEx	HS_AP1B1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AP1B1
DIP	DIP-24207N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-24207N
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/geno.1996.0431	http://dx.doi.org/10.1006/geno.1996.0431
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/990031	http://dx.doi.org/10.1038/990031
DOI	10.1093/hmg/3.8.1393	http://dx.doi.org/10.1093/hmg/3.8.1393
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1186/gb-2004-5-10-r84	http://dx.doi.org/10.1186/gb-2004-5-10-r84
EMBL	AC000041	http://www.ebi.ac.uk/ena/data/view/AC000041
EMBL	AC002059	http://www.ebi.ac.uk/ena/data/view/AC002059
EMBL	AF379038	http://www.ebi.ac.uk/ena/data/view/AF379038
EMBL	AF379039	http://www.ebi.ac.uk/ena/data/view/AF379039
EMBL	BC046242	http://www.ebi.ac.uk/ena/data/view/BC046242
EMBL	CT841508	http://www.ebi.ac.uk/ena/data/view/CT841508
EMBL	L13939	http://www.ebi.ac.uk/ena/data/view/L13939
EMBL	L48038	http://www.ebi.ac.uk/ena/data/view/L48038
EMBL	U36250	http://www.ebi.ac.uk/ena/data/view/U36250
EMBL	U36251	http://www.ebi.ac.uk/ena/data/view/U36251
EMBL	U36252	http://www.ebi.ac.uk/ena/data/view/U36252
EMBL	U36253	http://www.ebi.ac.uk/ena/data/view/U36253
EMBL	U36254	http://www.ebi.ac.uk/ena/data/view/U36254
EMBL	U36255	http://www.ebi.ac.uk/ena/data/view/U36255
EMBL	U36256	http://www.ebi.ac.uk/ena/data/view/U36256
EMBL	U36257	http://www.ebi.ac.uk/ena/data/view/U36257
EMBL	U36258	http://www.ebi.ac.uk/ena/data/view/U36258
EMBL	U36259	http://www.ebi.ac.uk/ena/data/view/U36259
EMBL	U36260	http://www.ebi.ac.uk/ena/data/view/U36260
EMBL	U36261	http://www.ebi.ac.uk/ena/data/view/U36261
EMBL	U36262	http://www.ebi.ac.uk/ena/data/view/U36262
EMBL	U36263	http://www.ebi.ac.uk/ena/data/view/U36263
EMBL	U36264	http://www.ebi.ac.uk/ena/data/view/U36264
EMBL	U36265	http://www.ebi.ac.uk/ena/data/view/U36265
EMBL	U36266	http://www.ebi.ac.uk/ena/data/view/U36266
EMBL	U36267	http://www.ebi.ac.uk/ena/data/view/U36267
EMBL	U36268	http://www.ebi.ac.uk/ena/data/view/U36268
Ensembl	ENST00000317368	http://www.ensembl.org/id/ENST00000317368
Ensembl	ENST00000357586	http://www.ensembl.org/id/ENST00000357586
Ensembl	ENST00000402502	http://www.ensembl.org/id/ENST00000402502
Ensembl	ENST00000405198	http://www.ensembl.org/id/ENST00000405198
Ensembl	ENST00000415447	http://www.ensembl.org/id/ENST00000415447
Ensembl	ENST00000432560	http://www.ensembl.org/id/ENST00000432560
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0030131	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030131
GO_component	GO:0030659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030659
GO_component	GO:0030669	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030669
GO_component	GO:0032588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032588
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0019901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019901
GO_process	GO:0006886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006886
GO_process	GO:0007368	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007368
GO_process	GO:0007507	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007507
GO_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GO_process	GO:0019886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019886
GO_process	GO:0050690	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050690
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
Gene3D	2.60.40.1150	http://www.cathdb.info/version/latest/superfamily/2.60.40.1150
Gene3D	3.30.310.10	http://www.cathdb.info/version/latest/superfamily/3.30.310.10
GeneCards	AP1B1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=AP1B1
GeneID	162	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=162
HGNC	HGNC:554	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:554
HOGENOM	HOG000163270	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000163270&db=HOGENOM6
HOVERGEN	HBG050515	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050515&db=HOVERGEN
HPA	HPA065226	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA065226
InParanoid	Q10567	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q10567
IntAct	Q10567	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q10567*
InterPro	IPR000225	http://www.ebi.ac.uk/interpro/entry/IPR000225
InterPro	IPR002553	http://www.ebi.ac.uk/interpro/entry/IPR002553
InterPro	IPR008152	http://www.ebi.ac.uk/interpro/entry/IPR008152
InterPro	IPR009028	http://www.ebi.ac.uk/interpro/entry/IPR009028
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR012295	http://www.ebi.ac.uk/interpro/entry/IPR012295
InterPro	IPR013037	http://www.ebi.ac.uk/interpro/entry/IPR013037
InterPro	IPR013041	http://www.ebi.ac.uk/interpro/entry/IPR013041
InterPro	IPR015151	http://www.ebi.ac.uk/interpro/entry/IPR015151
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
InterPro	IPR016342	http://www.ebi.ac.uk/interpro/entry/IPR016342
InterPro	IPR026739	http://www.ebi.ac.uk/interpro/entry/IPR026739
Jabion	162	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=162
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Gene	hsa:162	http://www.genome.jp/dbget-bin/www_bget?hsa:162
KEGG_Orthology	KO:K12392	http://www.genome.jp/dbget-bin/www_bget?KO:K12392
KEGG_Pathway	ko04142	http://www.genome.jp/kegg-bin/show_pathway?ko04142
MIM	600157	http://www.ncbi.nlm.nih.gov/omim/600157
MINT	MINT-1540570	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1540570
OrthoDB	EOG091G019U	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G019U
PANTHER	PTHR11134	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11134
PDB	4HMY	http://www.ebi.ac.uk/pdbe-srv/view/entry/4HMY
PDB	4P6Z	http://www.ebi.ac.uk/pdbe-srv/view/entry/4P6Z
PDBsum	4HMY	http://www.ebi.ac.uk/pdbsum/4HMY
PDBsum	4P6Z	http://www.ebi.ac.uk/pdbsum/4P6Z
PSORT	swissprot:AP1B1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AP1B1_HUMAN
PSORT-B	swissprot:AP1B1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AP1B1_HUMAN
PSORT2	swissprot:AP1B1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AP1B1_HUMAN
Pfam	PF01602	http://pfam.xfam.org/family/PF01602
Pfam	PF02883	http://pfam.xfam.org/family/PF02883
Pfam	PF09066	http://pfam.xfam.org/family/PF09066
PharmGKB	PA24844	http://www.pharmgkb.org/do/serve?objId=PA24844&objCls=Gene
Phobius	swissprot:AP1B1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AP1B1_HUMAN
PhylomeDB	Q10567	http://phylomedb.org/?seqid=Q10567
ProteinModelPortal	Q10567	http://www.proteinmodelportal.org/query/uniprot/Q10567
PubMed	10591208	http://www.ncbi.nlm.nih.gov/pubmed/10591208
PubMed	15461802	http://www.ncbi.nlm.nih.gov/pubmed/15461802
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	7987321	http://www.ncbi.nlm.nih.gov/pubmed/7987321
PubMed	8812422	http://www.ncbi.nlm.nih.gov/pubmed/8812422
Reactome	R-HSA-164940	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-164940
Reactome	R-HSA-2132295	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2132295
Reactome	R-HSA-432720	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432720
Reactome	R-HSA-432722	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432722
RefSeq	NP_001118	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001118
RefSeq	NP_001159491	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001159491
RefSeq	NP_663782	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_663782
SMART	SM00185	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00185
SMART	SM00809	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00809
SMART	SM01020	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01020
SMR	Q10567	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q10567
STRING	9606.ENSP00000350199	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000350199&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
SUPFAM	SSF49348	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49348
SUPFAM	SSF55711	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55711
UCSC	uc003afi	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003afi&org=rat
UniGene	Hs.368794	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.368794
UniProtKB	AP1B1_HUMAN	http://www.uniprot.org/uniprot/AP1B1_HUMAN
UniProtKB-AC	Q10567	http://www.uniprot.org/uniprot/Q10567
charge	swissprot:AP1B1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AP1B1_HUMAN
eggNOG	COG5096	http://eggnogapi.embl.de/nog_data/html/tree/COG5096
eggNOG	KOG1061	http://eggnogapi.embl.de/nog_data/html/tree/KOG1061
epestfind	swissprot:AP1B1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AP1B1_HUMAN
garnier	swissprot:AP1B1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AP1B1_HUMAN
helixturnhelix	swissprot:AP1B1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AP1B1_HUMAN
hmoment	swissprot:AP1B1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AP1B1_HUMAN
iep	swissprot:AP1B1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AP1B1_HUMAN
inforesidue	swissprot:AP1B1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AP1B1_HUMAN
neXtProt	NX_Q10567	http://www.nextprot.org/db/entry/NX_Q10567
octanol	swissprot:AP1B1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AP1B1_HUMAN
pepcoil	swissprot:AP1B1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AP1B1_HUMAN
pepdigest	swissprot:AP1B1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AP1B1_HUMAN
pepinfo	swissprot:AP1B1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AP1B1_HUMAN
pepnet	swissprot:AP1B1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AP1B1_HUMAN
pepstats	swissprot:AP1B1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AP1B1_HUMAN
pepwheel	swissprot:AP1B1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AP1B1_HUMAN
pepwindow	swissprot:AP1B1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AP1B1_HUMAN
sigcleave	swissprot:AP1B1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AP1B1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SO6A1_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q86UG4-1; Sequence=Displayed; Name=2; IsoId=Q86UG4-2; Sequence=VSP_028753; Note=No experimental confirmation available.; Name=3; IsoId=Q86UG4-3; Sequence=VSP_028753, VSP_028754; Note=No experimental confirmation available.; 
# AltName	SO6A1_HUMAN	Cancer/testis antigen 48
# AltName	SO6A1_HUMAN	Gonad-specific transporter
# AltName	SO6A1_HUMAN	Organic anion-transporting polypeptide 6A1
# AltName	SO6A1_HUMAN	Organic anion-transporting polypeptide I
# AltName	SO6A1_HUMAN	Solute carrier family 21 member 19
# BioGrid	126359	12
# CCDS	CCDS34206	-. [Q86UG4-1]
# CCDS	CCDS75282	-. [Q86UG4-2]
# CCDS	CCDS78042	-. [Q86UG4-3]
# CDD	cd06174	MFS
# Ensembl	ENST00000379807	ENSP00000369135; ENSG00000205359. [Q86UG4-1]
# Ensembl	ENST00000389019	ENSP00000373671; ENSG00000205359. [Q86UG4-2]
# Ensembl	ENST00000506729	ENSP00000421339; ENSG00000205359. [Q86UG4-1]
# ExpressionAtlas	Q86UG4	baseline and differential
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0015347	sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0043252	sodium-independent organic anion transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q86UG4	HS
# HGNC	HGNC:23613	SLCO6A1
# InterPro	IPR002350	Kazal_dom
# InterPro	IPR004156	OA_transporter
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02001	Solute carrier family
# MIM	613365	gene
# Organism	SO6A1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11388	PTHR11388
# PROSITE	PS51465	KAZAL_2
# Pfam	PF03137	OATP
# Pfam	PF07648	Kazal_2
# Proteomes	UP000005640	Chromosome 5
# RecName	SO6A1_HUMAN	Solute carrier organic anion transporter family member 6A1
# RefSeq	NP_001275931	NM_001289002.1. [Q86UG4-1]
# RefSeq	NP_001275933	NM_001289004.1. [Q86UG4-2]
# RefSeq	NP_001294943	NM_001308014.1
# RefSeq	NP_775759	NM_173488.4. [Q86UG4-1]
# RefSeq	XP_005271931	XM_005271874.3. [Q86UG4-1]
# SIMILARITY	Belongs to the organo anion transporter (TC 2.A.60) family. {ECO	0000305}. 
# SIMILARITY	Contains 1 Kazal-like domain. {ECO:0000255|PROSITE- ProRule	PRU00798}.
# SUBCELLULAR LOCATION	SO6A1_HUMAN	Cell membrane; Multi-pass membrane protein. 
# SUPFAM	SSF103473	SSF103473; 3
# TCDB	2.A.60.1.17	the organo anion transporter (oat) family
# TIGRFAMs	TIGR00805	oat
# TISSUE SPECIFICITY	SO6A1_HUMAN	Strongly expressed in testis. Weakly expressed in spleen, brain, fetal brain and placenta. Detected in lung tumors. {ECO 0000269|PubMed 12677006, ECO 0000269|PubMed 15546177}. 
# UCSC	uc003knn	human. [Q86UG4-1]
# eggNOG	ENOG410XRSF	LUCA
# eggNOG	KOG3626	Eukaryota
BLAST	swissprot:SO6A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SO6A1_HUMAN
BioCyc	ZFISH:G66-32472-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32472-MONOMER
COXPRESdb	133482	http://coxpresdb.jp/data/gene/133482.shtml
CleanEx	HS_SLCO6A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLCO6A1
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1210/me.2002-0304	http://dx.doi.org/10.1210/me.2002-0304
EMBL	AC094108	http://www.ebi.ac.uk/ena/data/view/AC094108
EMBL	AF505657	http://www.ebi.ac.uk/ena/data/view/AF505657
EMBL	AK131445	http://www.ebi.ac.uk/ena/data/view/AK131445
EMBL	AY273897	http://www.ebi.ac.uk/ena/data/view/AY273897
EMBL	BC034976	http://www.ebi.ac.uk/ena/data/view/BC034976
EMBL	CH471086	http://www.ebi.ac.uk/ena/data/view/CH471086
Ensembl	ENST00000379807	http://www.ensembl.org/id/ENST00000379807
Ensembl	ENST00000389019	http://www.ensembl.org/id/ENST00000389019
Ensembl	ENST00000506729	http://www.ensembl.org/id/ENST00000506729
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0015347	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015347
GO_process	GO:0043252	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043252
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLCO6A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLCO6A1
GeneID	133482	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=133482
GeneTree	ENSGT00760000119014	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119014
H-InvDB	HIX0024807	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0024807
HGNC	HGNC:23613	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:23613
HOGENOM	HOG000231270	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231270&db=HOGENOM6
HOVERGEN	HBG100565	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG100565&db=HOVERGEN
HPA	HPA054126	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA054126
InParanoid	Q86UG4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q86UG4
InterPro	IPR002350	http://www.ebi.ac.uk/interpro/entry/IPR002350
InterPro	IPR004156	http://www.ebi.ac.uk/interpro/entry/IPR004156
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	133482	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=133482
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:133482	http://www.genome.jp/dbget-bin/www_bget?hsa:133482
KEGG_Orthology	KO:K14357	http://www.genome.jp/dbget-bin/www_bget?KO:K14357
MIM	613365	http://www.ncbi.nlm.nih.gov/omim/613365
OMA	ALMRFIM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ALMRFIM
OrthoDB	EOG091G02FX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G02FX
PANTHER	PTHR11388	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11388
PROSITE	PS51465	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51465
PSORT	swissprot:SO6A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SO6A1_HUMAN
PSORT-B	swissprot:SO6A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SO6A1_HUMAN
PSORT2	swissprot:SO6A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SO6A1_HUMAN
Pfam	PF03137	http://pfam.xfam.org/family/PF03137
Pfam	PF07648	http://pfam.xfam.org/family/PF07648
PharmGKB	PA134949852	http://www.pharmgkb.org/do/serve?objId=PA134949852&objCls=Gene
Phobius	swissprot:SO6A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SO6A1_HUMAN
PhylomeDB	Q86UG4	http://phylomedb.org/?seqid=Q86UG4
ProteinModelPortal	Q86UG4	http://www.proteinmodelportal.org/query/uniprot/Q86UG4
PubMed	12677006	http://www.ncbi.nlm.nih.gov/pubmed/12677006
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15546177	http://www.ncbi.nlm.nih.gov/pubmed/15546177
RefSeq	NP_001275931	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001275931
RefSeq	NP_001275933	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001275933
RefSeq	NP_001294943	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001294943
RefSeq	NP_775759	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_775759
RefSeq	XP_005271931	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005271931
STRING	9606.ENSP00000369135	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000369135&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.60.1.17	http://www.tcdb.org/search/result.php?tc=2.A.60.1.17
TIGRFAMs	TIGR00805	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00805
UCSC	uc003knn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003knn&org=rat
UniGene	Hs.388874	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.388874
UniProtKB	SO6A1_HUMAN	http://www.uniprot.org/uniprot/SO6A1_HUMAN
UniProtKB-AC	Q86UG4	http://www.uniprot.org/uniprot/Q86UG4
charge	swissprot:SO6A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SO6A1_HUMAN
eggNOG	ENOG410XRSF	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRSF
eggNOG	KOG3626	http://eggnogapi.embl.de/nog_data/html/tree/KOG3626
epestfind	swissprot:SO6A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SO6A1_HUMAN
garnier	swissprot:SO6A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SO6A1_HUMAN
helixturnhelix	swissprot:SO6A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SO6A1_HUMAN
hmoment	swissprot:SO6A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SO6A1_HUMAN
iep	swissprot:SO6A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SO6A1_HUMAN
inforesidue	swissprot:SO6A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SO6A1_HUMAN
neXtProt	NX_Q86UG4	http://www.nextprot.org/db/entry/NX_Q86UG4
octanol	swissprot:SO6A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SO6A1_HUMAN
pepcoil	swissprot:SO6A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SO6A1_HUMAN
pepdigest	swissprot:SO6A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SO6A1_HUMAN
pepinfo	swissprot:SO6A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SO6A1_HUMAN
pepnet	swissprot:SO6A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SO6A1_HUMAN
pepstats	swissprot:SO6A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SO6A1_HUMAN
pepwheel	swissprot:SO6A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SO6A1_HUMAN
pepwindow	swissprot:SO6A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SO6A1_HUMAN
sigcleave	swissprot:SO6A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SO6A1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=eAE1, Erythrocyte; IsoId=P02730-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed	7506871}; Synonyms=kAE1, Kidney; IsoId=P02730-2; Sequence=VSP_057833; 
# AltName	B3AT_HUMAN	Anion exchange protein 1
# AltName	B3AT_HUMAN	CD233
# AltName	B3AT_HUMAN	Solute carrier family 4 member 1
# BioGrid	112412	11
# CCDS	CCDS11481	-. [P02730-1]
# ChiTaRS	SLC4A1	human
# DISEASE	B3AT_HUMAN	Cryohydrocytosis (CHC) [MIM 185020]  An autosomal dominant disorder of red cell membrane permeability characterized by cold-induced changes in cell volume, resulting in cold- sensitive stomatocytosis, and increased erythrocyte osmotic fragility and autohemolysis at 4 degrees Celsius. Patients present with mild to moderate hemolytic anemia, splenomegaly, fatigue, and pseudohyperkalemia due to a potassium leak from the erythrocytes. {ECO 0000269|PubMed 16227998}. Note=The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. 
# DISEASE	B3AT_HUMAN	Ovalocytosis, Southeast Asian (SAO) [MIM 166900]  A hereditary hematologic disorder characterized by ovalocytic erythrocytes that are rigid and exhibit reduced expression of many erythrocyte antigens. Clinical manifestations include mild hemolysis, intermittent jaundice and gallstones. However, the disorder is most often asymptomatic. {ECO 0000269|PubMed 1538405, ECO 0000269|PubMed 1722314}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	B3AT_HUMAN	Renal tubular acidosis, distal, autosomal dominant (AD- dRTA) [MIM 179800]  An autosomal dominant disease characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis. It is due to functional failure of alpha- intercalated cells of the cortical collecting duct of the distal nephron, where vectorial proton transport is required for urinary acidification. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	B3AT_HUMAN	Renal tubular acidosis, distal, with hemolytic anemia (dRTA-HA) [MIM 611590]  A disease characterized by the association of hemolytic anemia with distal renal tubular acidosis, the reduced ability to acidify urine resulting in variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis. {ECO 0000269|PubMed 10926824, ECO 0000269|PubMed 15211439, ECO 0000269|PubMed 9854053}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	B3AT_HUMAN	Renal tubular acidosis, distal, with normal red cell morphology (dRTA-NRC) [MIM 611590]  A disease characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis. It is due to functional failure of alpha- intercalated cells of the cortical collecting duct of the distal nephron, where vectorial proton transport is required for urinary acidification. {ECO 0000269|PubMed 15211439}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	B3AT_HUMAN	Spherocytosis 4 (SPH4) [MIM 612653]  Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. {ECO 0000269|PubMed 10580570, ECO 0000269|PubMed 10745622, ECO 0000269|PubMed 10942416, ECO 0000269|PubMed 11380459, ECO 0000269|PubMed 1378323, ECO 0000269|PubMed 15813913, ECO 0000269|PubMed 16227998, ECO 0000269|PubMed 7530501, ECO 0000269|PubMed 8547122, ECO 0000269|PubMed 8640229, ECO 0000269|PubMed 8943874, ECO 0000269|PubMed 9012689, ECO 0000269|PubMed 9207478, ECO 0000269|PubMed 9233560, ECO 0000269|PubMed 9973643}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# ENZYME REGULATION	B3AT_HUMAN	Phenyl isothiocyanate inhibits anion transport in vitro. 
# Ensembl	ENST00000262418	ENSP00000262418; ENSG00000004939. [P02730-1]
# ExpressionAtlas	P02730	baseline and differential
# FUNCTION	B3AT_HUMAN	Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1 1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine. {ECO 0000269|PubMed 10926824, ECO 0000269|PubMed 14734552, ECO 0000269|PubMed 1538405, ECO 0000269|PubMed 20151848, ECO 0000269|PubMed 24121512}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0016323	basolateral plasma membrane; IDA:UniProtKB.
# GO_component	GO:0030018	Z disc; ISS:UniProtKB.
# GO_component	GO:0030863	cortical cytoskeleton; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_component	GO:0072562	blood microparticle; IDA:UniProtKB.
# GO_function	B3AT_HUMAN	GO 0015301 anion anion antiporter activity; IDA UniProtKB.
# GO_function	GO:0005452	inorganic anion exchanger activity; IDA:UniProtKB.
# GO_function	GO:0008509	anion transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0015106	bicarbonate transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015108	chloride transmembrane transporter activity; ISS:UniProtKB.
# GO_function	GO:0030506	ankyrin binding; IPI:BHF-UCL.
# GO_function	GO:0042803	protein homodimerization activity; IPI:BHF-UCL.
# GO_function	GO:0043495	protein anchor; TAS:BHF-UCL.
# GO_process	GO:0006820	anion transport; IDA:UniProtKB.
# GO_process	GO:0006821	chloride transport; ISS:UniProtKB.
# GO_process	GO:0006873	cellular ion homeostasis; TAS:ProtInc.
# GO_process	GO:0015701	bicarbonate transport; IDA:UniProtKB.
# GO_process	GO:0051453	regulation of intracellular pH; IBA:GO_Central.
# GO_process	GO:1902476	chloride transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005856	cytoskeleton
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008092	cytoskeletal protein binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.1100.10	-; 1.
# Genevisible	P02730	HS
# HGNC	HGNC:11027	SLC4A1
# INTERACTION	B3AT_HUMAN	P05026 ATP1B1; NbExp=8; IntAct=EBI-7576138, EBI-714630; A5K5E5 PVX_088820 (xeno); NbExp=8; IntAct=EBI-7576138, EBI-11621504; 
# IntAct	P02730	5
# InterPro	IPR001717	Anion_exchange
# InterPro	IPR002977	Anion_exchange_1
# InterPro	IPR003020	HCO3_transpt_euk
# InterPro	IPR011531	HCO3_transpt_C
# InterPro	IPR013769	Band3_cytoplasmic_dom
# InterPro	IPR016152	PTrfase/Anion_transptr
# InterPro	IPR018241	Anion_exchange_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Brite	ko04090	 Cellular antigens
# KEGG_Disease	H00230	[Hematologic disease] Hereditary spherocytosis (SPH)
# KEGG_Disease	H00231	[Hematologic disease] Hereditary elliptocytosis (HE)
# KEGG_Disease	H00232	[Hematologic disease] Familial pseudohyperkalemia (FP)
# KEGG_Disease	H00428	[Urinary system disease] Distal renal tubular acidosis (RTA type 1)
# KEGG_Pathway	ko04966	Collecting duct acid secretion
# MIM	109270	gene+phenotype
# MIM	110500	phenotype
# MIM	112010	phenotype
# MIM	112050	phenotype
# MIM	130600	phenotype
# MIM	166900	phenotype
# MIM	179800	phenotype
# MIM	185020	phenotype
# MIM	601550	phenotype
# MIM	601551	phenotype
# MIM	611162	phenotype
# MIM	611590	phenotype
# MIM	612653	phenotype
# Organism	B3AT_HUMAN	Homo sapiens (Human)
# Orphanet	398088	Hereditary cryohydrocytosis with normal stomatin
# Orphanet	822	Hereditary spherocytosis
# Orphanet	93608	Autosomal dominant distal renal tubular acidosis
# Orphanet	93610	Distal renal tubular acidosis with anemia
# Orphanet	98868	Southeast Asian ovalocytosis
# PANTHER	PTHR11453	PTHR11453
# PDB	1BH7	NMR; -; A=803-835
# PDB	1BNX	NMR; -; A=389-430
# PDB	1BTQ	NMR; -; A=405-424
# PDB	1BTR	NMR; -; A=405-424
# PDB	1BTS	NMR; -; A=436-456
# PDB	1BTT	NMR; -; A=436-456
# PDB	1BZK	NMR; -; A=389-430
# PDB	1HYN	X-ray; 2.60 A; P/Q/R/S=1-379
# PDB	2BTA	NMR; -; A=1-15
# PDB	2BTB	NMR; -; A=1-15
# PDB	3BTB	NMR; -; A=1-15
# PDB	4KY9	X-ray; 2.23 A; A/P=51-356
# PDB	4YZF	X-ray; 3.50 A; A/B/C/D=1-911
# PIR	A36218	B3HU
# POLYMORPHISM	B3AT_HUMAN	SLC4A1 is responsible for the Diego blood group system. The molecular basis of the Di(a)=Di1/Di(b)/Di2 blood group antigens is a single variation in position 854; Leu-854 corresponds to Di(a) and Pro-854 to Di(b). The molecular basis of the Wr(a)=Di3/Wr(b)/Di4 blood group antigens is a single variation in position 658; Lys-658 corresponds to Wr(a) and Glu-658 to Wr(b). The blood group antigens Wd(a)=Di5 (Waldner-type) has Met- 557; Rb(a)=Di6 has Leu-548 and WARR=Di7 has Ile-552. 
# POLYMORPHISM	Genetic variations in SLC4A1 are involved in resistance to malaria [MIM	611162]. 
# POLYMORPHISM	SLC4A1 is responsible for the Froese blood group system (FR) [MIM	601551]. FR(a+) has a Lys at position 480 and FR(a-) has a Glu. 
# POLYMORPHISM	SLC4A1 is responsible for the Swann blood group system (SW) [MIM	601550]. Sw(a+) has a Gln or a Trp at position 646 and Sw(a-) has an Arg. 
# PRINTS	PR00165	ANIONEXCHNGR
# PRINTS	PR01187	ANIONEXHNGR1
# PRINTS	PR01231	HCO3TRNSPORT
# PROSITE	PS00219	ANION_EXCHANGER_1
# PROSITE	PS00220	ANION_EXCHANGER_2
# PTM	B3AT_HUMAN	N-glycosylated. {ECO 0000269|PubMed 26542571}. 
# PTM	B3AT_HUMAN	Phosphorylated on Tyr-359 and Tyr-904 most likely by LYN. PP1-inhibited phosphorylation that follows Tyr-8 and Tyr-21 phosphorylation. {ECO 0000269|PubMed 10942405, ECO 0000269|PubMed 1998697}. 
# PTM	B3AT_HUMAN	Phosphorylated on Tyr-8 and Tyr-21 most likely by SYK. PP1- resistant phosphorylation that precedes Tyr-359 and Tyr-904 phosphorylation. {ECO 0000269|PubMed 10942405, ECO 0000269|PubMed 1998697}. 
# Pfam	PF00955	HCO3_cotransp; 2
# Pfam	PF07565	Band_3_cyto
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-1237044	Erythrocytes take up carbon dioxide and release oxygen
# Reactome	R-HSA-1247673	Erythrocytes take up oxygen and release carbon dioxide
# Reactome	R-HSA-425381	Bicarbonate transporters
# RecName	B3AT_HUMAN	Band 3 anion transport protein
# RefSeq	NP_000333	NM_000342.3. [P02730-1]
# RefSeq	XP_005257650	XM_005257593.4. [P02730-2]
# SIMILARITY	Belongs to the anion exchanger (TC 2.A.31) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	B3AT_HUMAN	Cell membrane {ECO 0000269|PubMed 10926824, ECO 0000269|PubMed 24121512, ECO 0000269|PubMed 26542571, ECO 0000269|PubMed 7506871}; Multi-pass membrane protein {ECO 0000269|PubMed 26542571}. Basolateral cell membrane {ECO 0000269|PubMed 7506871}; Multi-pass membrane protein {ECO 0000269|PubMed 7506871}. Note=Detected in the erythrocyte cell membrane and on the basolateral membrane of alpha- intercalated cells in the collecting duct in the kidney. {ECO 0000269|PubMed 7506871}. 
# SUBUNIT	B3AT_HUMAN	A dimer in solution, but in its membrane environment, it exists primarily as a mixture of dimers and tetramers and spans the membrane asymmetrically. Interacts (via cytoplasmic N-terminal domain) with ANK1 (via N-terminal ANK repeats); tetramer formation is critical for ankyrin association. Interacts with STOM. Isoform 2 interacts with TM139 (PubMed 26049106). {ECO 0000269|PubMed 11049968, ECO 0000269|PubMed 20151848, ECO 0000269|PubMed 23219802, ECO 0000269|PubMed 26049106, ECO 0000269|PubMed 7665627}. 
# SUPFAM	SSF55804	SSF55804
# TCDB	2.A.31.1	the anion exchanger (ae) family
# TIGRFAMs	TIGR00834	ae
# TISSUE SPECIFICITY	B3AT_HUMAN	Detected in erythrocytes (at protein level) (PubMed 7506871, PubMed 26542571). Isoform 2 is expressed in kidney (at protein level) (PubMed 7506871). {ECO 0000269|PubMed 10926824, ECO 0000269|PubMed 1538405, ECO 0000269|PubMed 23219802, ECO 0000269|PubMed 26542571, ECO 0000269|PubMed 7506871}. 
# UCSC	uc002igf	human. [P02730-1]
# WEB RESOURCE	B3AT_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/SLC4A1ID42325ch17q21.html";
# WEB RESOURCE	B3AT_HUMAN	Name=SeattleSNPs; URL="http //pga.gs.washington.edu/data/slc4a1/"; 
# WEB RESOURCE	B3AT_HUMAN	Name=Wikipedia; Note=Band 3 entry; URL="https //en.wikipedia.org/wiki/Band_3"; 
# WEB RESOURCE	B3AT_HUMAN	Name=dbRBC/BGMUT; Note=Blood group antigen gene mutation database; URL="https //www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=diego"; 
# eggNOG	ENOG410XPHD	LUCA
# eggNOG	KOG1172	Eukaryota
BLAST	swissprot:B3AT_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:B3AT_HUMAN
BioCyc	ZFISH:ENSG00000004939-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000004939-MONOMER
COXPRESdb	6521	http://coxpresdb.jp/data/gene/6521.shtml
DIP	DIP-42428N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-42428N
DOI	10.1007/s00467-005-2061-z	http://dx.doi.org/10.1007/s00467-005-2061-z
DOI	10.1016/0005-2736(91)90291-F	http://dx.doi.org/10.1016/0005-2736(91)90291-F
DOI	10.1016/0022-2836(92)90254-H	http://dx.doi.org/10.1016/0022-2836(92)90254-H
DOI	10.1016/0167-4838(89)90116-7	http://dx.doi.org/10.1016/0167-4838(89)90116-7
DOI	10.1016/j.bbamem.2012.11.030	http://dx.doi.org/10.1016/j.bbamem.2012.11.030
DOI	10.1016/j.bbrc.2015.05.128	http://dx.doi.org/10.1016/j.bbrc.2015.05.128
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/bi00051a005	http://dx.doi.org/10.1021/bi00051a005
DOI	10.1021/bi971445b	http://dx.doi.org/10.1021/bi971445b
DOI	10.1021/bi973158d	http://dx.doi.org/10.1021/bi973158d
DOI	10.1034/j.1600-0854.2000.011208.x	http://dx.doi.org/10.1034/j.1600-0854.2000.011208.x
DOI	10.1038/ng0696-214	http://dx.doi.org/10.1038/ng0696-214
DOI	10.1038/ng1656	http://dx.doi.org/10.1038/ng1656
DOI	10.1042/0264-6021:3490051	http://dx.doi.org/10.1042/0264-6021:3490051
DOI	10.1042/bj2130577	http://dx.doi.org/10.1042/bj2130577
DOI	10.1042/bj2560703	http://dx.doi.org/10.1042/bj2560703
DOI	10.1042/bj2930317	http://dx.doi.org/10.1042/bj2930317
DOI	10.1042/bj3500041	http://dx.doi.org/10.1042/bj3500041
DOI	10.1042/bst0260516	http://dx.doi.org/10.1042/bst0260516
DOI	10.1046/j.1365-2141.1997.1893005.x	http://dx.doi.org/10.1046/j.1365-2141.1997.1893005.x
DOI	10.1046/j.1365-2141.1997.8732504.x	http://dx.doi.org/10.1046/j.1365-2141.1997.8732504.x
DOI	10.1046/j.1365-2141.2001.02800.x	http://dx.doi.org/10.1046/j.1365-2141.2001.02800.x
DOI	10.1046/j.1537-2995.1997.37697335155.x	http://dx.doi.org/10.1046/j.1537-2995.1997.37697335155.x
DOI	10.1046/j.1537-2995.1998.38898375513.x	http://dx.doi.org/10.1046/j.1537-2995.1998.38898375513.x
DOI	10.1046/j.1537-2995.2000.40030325.x	http://dx.doi.org/10.1046/j.1537-2995.2000.40030325.x
DOI	10.1046/j.1537-2995.2000.40101246.x	http://dx.doi.org/10.1046/j.1537-2995.2000.40101246.x
DOI	10.1053/j.ajkd.2004.03.033	http://dx.doi.org/10.1053/j.ajkd.2004.03.033
DOI	10.1073/pnas.86.23.9089	http://dx.doi.org/10.1073/pnas.86.23.9089
DOI	10.1073/pnas.88.24.11022	http://dx.doi.org/10.1073/pnas.88.24.11022
DOI	10.1073/pnas.95.11.6337	http://dx.doi.org/10.1073/pnas.95.11.6337
DOI	10.1074/jbc.270.37.22050	http://dx.doi.org/10.1074/jbc.270.37.22050
DOI	10.1074/jbc.M113.511865	http://dx.doi.org/10.1074/jbc.M113.511865
DOI	10.1074/jbc.M400188200	http://dx.doi.org/10.1074/jbc.M400188200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1365-2141.1995.tb05393.x	http://dx.doi.org/10.1111/j.1365-2141.1995.tb05393.x
DOI	10.1111/j.1432-1033.1994.tb18757.x	http://dx.doi.org/10.1111/j.1432-1033.1994.tb18757.x
DOI	10.1111/j.1600-0609.2004.00405.x	http://dx.doi.org/10.1111/j.1600-0609.2004.00405.x
DOI	10.1126/science.aaa4335	http://dx.doi.org/10.1126/science.aaa4335
DOI	10.1152/ajpcell.00054.2011	http://dx.doi.org/10.1152/ajpcell.00054.2011
DOI	10.1159/000040904	http://dx.doi.org/10.1159/000040904
DOI	10.1159/000056733	http://dx.doi.org/10.1159/000056733
DOI	10.1172/JCI119694	http://dx.doi.org/10.1172/JCI119694
DOI	10.1172/JCI4836	http://dx.doi.org/10.1172/JCI4836
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.3109/09687681003588020	http://dx.doi.org/10.3109/09687681003588020
EMBL	BC096106	http://www.ebi.ac.uk/ena/data/view/BC096106
EMBL	BC096107	http://www.ebi.ac.uk/ena/data/view/BC096107
EMBL	BC099628	http://www.ebi.ac.uk/ena/data/view/BC099628
EMBL	BC099629	http://www.ebi.ac.uk/ena/data/view/BC099629
EMBL	BC101570	http://www.ebi.ac.uk/ena/data/view/BC101570
EMBL	BC101574	http://www.ebi.ac.uk/ena/data/view/BC101574
EMBL	CH471178	http://www.ebi.ac.uk/ena/data/view/CH471178
EMBL	DQ072115	http://www.ebi.ac.uk/ena/data/view/DQ072115
EMBL	DQ419529	http://www.ebi.ac.uk/ena/data/view/DQ419529
EMBL	GQ981383	http://www.ebi.ac.uk/ena/data/view/GQ981383
EMBL	GQ981384	http://www.ebi.ac.uk/ena/data/view/GQ981384
EMBL	M27819	http://www.ebi.ac.uk/ena/data/view/M27819
EMBL	S68680	http://www.ebi.ac.uk/ena/data/view/S68680
EMBL	X12609	http://www.ebi.ac.uk/ena/data/view/X12609
Ensembl	ENST00000262418	http://www.ensembl.org/id/ENST00000262418
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0030018	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030018
GO_component	GO:0030863	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030863
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_component	GO:0072562	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072562
GO_function	GO:0005452	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005452
GO_function	GO:0008509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008509
GO_function	GO:0015106	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015106
GO_function	GO:0015108	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015108
GO_function	GO:0015301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015301
GO_function	GO:0030506	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030506
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_function	GO:0043495	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043495
GO_process	GO:0006820	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006820
GO_process	GO:0006821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006821
GO_process	GO:0006873	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006873
GO_process	GO:0015701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015701
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.1100.10	http://www.cathdb.info/version/latest/superfamily/3.40.1100.10
GeneCards	SLC4A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC4A1
GeneID	6521	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6521
GeneTree	ENSGT00760000119021	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119021
HGNC	HGNC:11027	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11027
HOVERGEN	HBG004326	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004326&db=HOVERGEN
HPA	CAB034438	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB034438
HPA	HPA015584	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA015584
HPA	HPA063911	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA063911
InParanoid	P02730	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P02730
IntAct	P02730	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P02730*
InterPro	IPR001717	http://www.ebi.ac.uk/interpro/entry/IPR001717
InterPro	IPR002977	http://www.ebi.ac.uk/interpro/entry/IPR002977
InterPro	IPR003020	http://www.ebi.ac.uk/interpro/entry/IPR003020
InterPro	IPR011531	http://www.ebi.ac.uk/interpro/entry/IPR011531
InterPro	IPR013769	http://www.ebi.ac.uk/interpro/entry/IPR013769
InterPro	IPR016152	http://www.ebi.ac.uk/interpro/entry/IPR016152
InterPro	IPR018241	http://www.ebi.ac.uk/interpro/entry/IPR018241
Jabion	6521	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6521
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Brite	ko04090	http://www.genome.jp/dbget-bin/www_bget?ko04090
KEGG_Disease	H00230	http://www.genome.jp/dbget-bin/www_bget?H00230
KEGG_Disease	H00231	http://www.genome.jp/dbget-bin/www_bget?H00231
KEGG_Disease	H00232	http://www.genome.jp/dbget-bin/www_bget?H00232
KEGG_Disease	H00428	http://www.genome.jp/dbget-bin/www_bget?H00428
KEGG_Gene	hsa:6521	http://www.genome.jp/dbget-bin/www_bget?hsa:6521
KEGG_Orthology	KO:K06573	http://www.genome.jp/dbget-bin/www_bget?KO:K06573
KEGG_Pathway	ko04966	http://www.genome.jp/kegg-bin/show_pathway?ko04966
MIM	109270	http://www.ncbi.nlm.nih.gov/omim/109270
MIM	110500	http://www.ncbi.nlm.nih.gov/omim/110500
MIM	112010	http://www.ncbi.nlm.nih.gov/omim/112010
MIM	112050	http://www.ncbi.nlm.nih.gov/omim/112050
MIM	130600	http://www.ncbi.nlm.nih.gov/omim/130600
MIM	166900	http://www.ncbi.nlm.nih.gov/omim/166900
MIM	179800	http://www.ncbi.nlm.nih.gov/omim/179800
MIM	185020	http://www.ncbi.nlm.nih.gov/omim/185020
MIM	601550	http://www.ncbi.nlm.nih.gov/omim/601550
MIM	601551	http://www.ncbi.nlm.nih.gov/omim/601551
MIM	611162	http://www.ncbi.nlm.nih.gov/omim/611162
MIM	611590	http://www.ncbi.nlm.nih.gov/omim/611590
MIM	612653	http://www.ncbi.nlm.nih.gov/omim/612653
MINT	MINT-1344291	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1344291
OMA	FKPPKYH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FKPPKYH
Orphanet	398088	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=398088
Orphanet	822	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=822
Orphanet	93608	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=93608
Orphanet	93610	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=93610
Orphanet	98868	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98868
OrthoDB	EOG091G01FT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01FT
PANTHER	PTHR11453	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11453
PDB	1BH7	http://www.ebi.ac.uk/pdbe-srv/view/entry/1BH7
PDB	1BNX	http://www.ebi.ac.uk/pdbe-srv/view/entry/1BNX
PDB	1BTQ	http://www.ebi.ac.uk/pdbe-srv/view/entry/1BTQ
PDB	1BTR	http://www.ebi.ac.uk/pdbe-srv/view/entry/1BTR
PDB	1BTS	http://www.ebi.ac.uk/pdbe-srv/view/entry/1BTS
PDB	1BTT	http://www.ebi.ac.uk/pdbe-srv/view/entry/1BTT
PDB	1BZK	http://www.ebi.ac.uk/pdbe-srv/view/entry/1BZK
PDB	1HYN	http://www.ebi.ac.uk/pdbe-srv/view/entry/1HYN
PDB	2BTA	http://www.ebi.ac.uk/pdbe-srv/view/entry/2BTA
PDB	2BTB	http://www.ebi.ac.uk/pdbe-srv/view/entry/2BTB
PDB	3BTB	http://www.ebi.ac.uk/pdbe-srv/view/entry/3BTB
PDB	4KY9	http://www.ebi.ac.uk/pdbe-srv/view/entry/4KY9
PDB	4YZF	http://www.ebi.ac.uk/pdbe-srv/view/entry/4YZF
PDBsum	1BH7	http://www.ebi.ac.uk/pdbsum/1BH7
PDBsum	1BNX	http://www.ebi.ac.uk/pdbsum/1BNX
PDBsum	1BTQ	http://www.ebi.ac.uk/pdbsum/1BTQ
PDBsum	1BTR	http://www.ebi.ac.uk/pdbsum/1BTR
PDBsum	1BTS	http://www.ebi.ac.uk/pdbsum/1BTS
PDBsum	1BTT	http://www.ebi.ac.uk/pdbsum/1BTT
PDBsum	1BZK	http://www.ebi.ac.uk/pdbsum/1BZK
PDBsum	1HYN	http://www.ebi.ac.uk/pdbsum/1HYN
PDBsum	2BTA	http://www.ebi.ac.uk/pdbsum/2BTA
PDBsum	2BTB	http://www.ebi.ac.uk/pdbsum/2BTB
PDBsum	3BTB	http://www.ebi.ac.uk/pdbsum/3BTB
PDBsum	4KY9	http://www.ebi.ac.uk/pdbsum/4KY9
PDBsum	4YZF	http://www.ebi.ac.uk/pdbsum/4YZF
PRINTS	PR00165	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00165
PRINTS	PR01187	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01187
PRINTS	PR01231	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01231
PROSITE	PS00219	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00219
PROSITE	PS00220	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00220
PSORT	swissprot:B3AT_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:B3AT_HUMAN
PSORT-B	swissprot:B3AT_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:B3AT_HUMAN
PSORT2	swissprot:B3AT_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:B3AT_HUMAN
Pfam	PF00955	http://pfam.xfam.org/family/PF00955
Pfam	PF07565	http://pfam.xfam.org/family/PF07565
PharmGKB	PA35895	http://www.pharmgkb.org/do/serve?objId=PA35895&objCls=Gene
Phobius	swissprot:B3AT_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:B3AT_HUMAN
PhylomeDB	P02730	http://phylomedb.org/?seqid=P02730
ProteinModelPortal	P02730	http://www.proteinmodelportal.org/query/uniprot/P02730
PubMed	10580570	http://www.ncbi.nlm.nih.gov/pubmed/10580570
PubMed	10738034	http://www.ncbi.nlm.nih.gov/pubmed/10738034
PubMed	10745622	http://www.ncbi.nlm.nih.gov/pubmed/10745622
PubMed	10861210	http://www.ncbi.nlm.nih.gov/pubmed/10861210
PubMed	10926824	http://www.ncbi.nlm.nih.gov/pubmed/10926824
PubMed	10942405	http://www.ncbi.nlm.nih.gov/pubmed/10942405
PubMed	10942416	http://www.ncbi.nlm.nih.gov/pubmed/10942416
PubMed	11049968	http://www.ncbi.nlm.nih.gov/pubmed/11049968
PubMed	11061863	http://www.ncbi.nlm.nih.gov/pubmed/11061863
PubMed	11155072	http://www.ncbi.nlm.nih.gov/pubmed/11155072
PubMed	11208088	http://www.ncbi.nlm.nih.gov/pubmed/11208088
PubMed	11380459	http://www.ncbi.nlm.nih.gov/pubmed/11380459
PubMed	1352774	http://www.ncbi.nlm.nih.gov/pubmed/1352774
PubMed	1378323	http://www.ncbi.nlm.nih.gov/pubmed/1378323
PubMed	14734552	http://www.ncbi.nlm.nih.gov/pubmed/14734552
PubMed	15211439	http://www.ncbi.nlm.nih.gov/pubmed/15211439
PubMed	1527044	http://www.ncbi.nlm.nih.gov/pubmed/1527044
PubMed	1538405	http://www.ncbi.nlm.nih.gov/pubmed/1538405
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15813913	http://www.ncbi.nlm.nih.gov/pubmed/15813913
PubMed	16227998	http://www.ncbi.nlm.nih.gov/pubmed/16227998
PubMed	16252102	http://www.ncbi.nlm.nih.gov/pubmed/16252102
PubMed	1678289	http://www.ncbi.nlm.nih.gov/pubmed/1678289
PubMed	1722314	http://www.ncbi.nlm.nih.gov/pubmed/1722314
PubMed	1885574	http://www.ncbi.nlm.nih.gov/pubmed/1885574
PubMed	1998697	http://www.ncbi.nlm.nih.gov/pubmed/1998697
PubMed	20151848	http://www.ncbi.nlm.nih.gov/pubmed/20151848
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21849667	http://www.ncbi.nlm.nih.gov/pubmed/21849667
PubMed	23219802	http://www.ncbi.nlm.nih.gov/pubmed/23219802
PubMed	24121512	http://www.ncbi.nlm.nih.gov/pubmed/24121512
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	2594752	http://www.ncbi.nlm.nih.gov/pubmed/2594752
PubMed	26049106	http://www.ncbi.nlm.nih.gov/pubmed/26049106
PubMed	26542571	http://www.ncbi.nlm.nih.gov/pubmed/26542571
PubMed	2790053	http://www.ncbi.nlm.nih.gov/pubmed/2790053
PubMed	3223947	http://www.ncbi.nlm.nih.gov/pubmed/3223947
PubMed	3372523	http://www.ncbi.nlm.nih.gov/pubmed/3372523
PubMed	6345535	http://www.ncbi.nlm.nih.gov/pubmed/6345535
PubMed	6615451	http://www.ncbi.nlm.nih.gov/pubmed/6615451
PubMed	701248	http://www.ncbi.nlm.nih.gov/pubmed/701248
PubMed	7506871	http://www.ncbi.nlm.nih.gov/pubmed/7506871
PubMed	7530501	http://www.ncbi.nlm.nih.gov/pubmed/7530501
PubMed	7665627	http://www.ncbi.nlm.nih.gov/pubmed/7665627
PubMed	7812009	http://www.ncbi.nlm.nih.gov/pubmed/7812009
PubMed	8045253	http://www.ncbi.nlm.nih.gov/pubmed/8045253
PubMed	8168533	http://www.ncbi.nlm.nih.gov/pubmed/8168533
PubMed	8206915	http://www.ncbi.nlm.nih.gov/pubmed/8206915
PubMed	8343110	http://www.ncbi.nlm.nih.gov/pubmed/8343110
PubMed	8471774	http://www.ncbi.nlm.nih.gov/pubmed/8471774
PubMed	8508760	http://www.ncbi.nlm.nih.gov/pubmed/8508760
PubMed	8527430	http://www.ncbi.nlm.nih.gov/pubmed/8527430
PubMed	8547122	http://www.ncbi.nlm.nih.gov/pubmed/8547122
PubMed	8640229	http://www.ncbi.nlm.nih.gov/pubmed/8640229
PubMed	8943874	http://www.ncbi.nlm.nih.gov/pubmed/8943874
PubMed	9012689	http://www.ncbi.nlm.nih.gov/pubmed/9012689
PubMed	9191821	http://www.ncbi.nlm.nih.gov/pubmed/9191821
PubMed	9207478	http://www.ncbi.nlm.nih.gov/pubmed/9207478
PubMed	9233560	http://www.ncbi.nlm.nih.gov/pubmed/9233560
PubMed	9312167	http://www.ncbi.nlm.nih.gov/pubmed/9312167
PubMed	9454576	http://www.ncbi.nlm.nih.gov/pubmed/9454576
PubMed	9600966	http://www.ncbi.nlm.nih.gov/pubmed/9600966
PubMed	9709005	http://www.ncbi.nlm.nih.gov/pubmed/9709005
PubMed	9709782	http://www.ncbi.nlm.nih.gov/pubmed/9709782
PubMed	9765907	http://www.ncbi.nlm.nih.gov/pubmed/9765907
PubMed	9845551	http://www.ncbi.nlm.nih.gov/pubmed/9845551
PubMed	9854053	http://www.ncbi.nlm.nih.gov/pubmed/9854053
PubMed	9973643	http://www.ncbi.nlm.nih.gov/pubmed/9973643
Reactome	R-HSA-1237044	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1237044
Reactome	R-HSA-1247673	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1247673
Reactome	R-HSA-425381	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425381
RefSeq	NP_000333	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000333
RefSeq	XP_005257650	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005257650
SMR	P02730	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P02730
STRING	9606.ENSP00000262418	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000262418&targetmode=cogs
SUPFAM	SSF55804	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55804
TCDB	2.A.31.1	http://www.tcdb.org/search/result.php?tc=2.A.31.1
TIGRFAMs	TIGR00834	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00834
UCSC	uc002igf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002igf&org=rat
UniGene	Hs.210751	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.210751
UniGene	Hs.443948	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.443948
UniProtKB	B3AT_HUMAN	http://www.uniprot.org/uniprot/B3AT_HUMAN
UniProtKB-AC	P02730	http://www.uniprot.org/uniprot/P02730
charge	swissprot:B3AT_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:B3AT_HUMAN
eggNOG	ENOG410XPHD	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPHD
eggNOG	KOG1172	http://eggnogapi.embl.de/nog_data/html/tree/KOG1172
epestfind	swissprot:B3AT_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:B3AT_HUMAN
garnier	swissprot:B3AT_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:B3AT_HUMAN
helixturnhelix	swissprot:B3AT_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:B3AT_HUMAN
hmoment	swissprot:B3AT_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:B3AT_HUMAN
iep	swissprot:B3AT_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:B3AT_HUMAN
inforesidue	swissprot:B3AT_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:B3AT_HUMAN
neXtProt	NX_P02730	http://www.nextprot.org/db/entry/NX_P02730
octanol	swissprot:B3AT_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:B3AT_HUMAN
pepcoil	swissprot:B3AT_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:B3AT_HUMAN
pepdigest	swissprot:B3AT_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:B3AT_HUMAN
pepinfo	swissprot:B3AT_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:B3AT_HUMAN
pepnet	swissprot:B3AT_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:B3AT_HUMAN
pepstats	swissprot:B3AT_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:B3AT_HUMAN
pepwheel	swissprot:B3AT_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:B3AT_HUMAN
pepwindow	swissprot:B3AT_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:B3AT_HUMAN
sigcleave	swissprot:B3AT_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:B3AT_HUMAN
## Database	ID	URL or Descriptions
# AltName	ADT3_HUMAN	ADP,ATP carrier protein 3
# AltName	ADT3_HUMAN	ADP,ATP carrier protein, isoform T2
# AltName	ADT3_HUMAN	Adenine nucleotide translocator 3
# AltName	ADT3_HUMAN	Solute carrier family 25 member 6
# AltName	ADT3_HUMAN	Solute carrier family 25 member 6
# BioGrid	106790	112
# DrugBank	DB00720	Clodronate
# Ensembl	ENST00000381401	ENSP00000370808; ENSG00000169100
# ExpressionAtlas	P12236	baseline and differential
# FUNCTION	ADT3_HUMAN	Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. {ECO 0000269|PubMed 15033708}. 
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0005744	mitochondrial inner membrane presequence translocase complex; TAS:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0031012	extracellular matrix; IDA:BHF-UCL.
# GO_function	ADT3_HUMAN	GO 0005471 ATP ADP antiporter activity; NAS UniProtKB.
# GO_function	GO:0015207	adenine transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0006626	protein targeting to mitochondrion; TAS:Reactome.
# GO_process	GO:0006915	apoptotic process; IEA:UniProtKB-KW.
# GO_process	GO:0046732	active induction of host immune response by virus; TAS:Reactome.
# GO_process	GO:0050796	regulation of insulin secretion; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006605	protein targeting
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0008219	cell death
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# Gene3D	1.50.40.10	-; 1.
# Genevisible	P12236	HS
# HGNC	HGNC:10992	SLC25A6
# INTERACTION	ADT3_HUMAN	P63010 AP2B1; NbExp=3; IntAct=EBI-356254, EBI-432924; Q15323 KRT31; NbExp=3; IntAct=EBI-356254, EBI-948001; Q5S007 LRRK2; NbExp=2; IntAct=EBI-356254, EBI-5323863; Q9BRK4 LZTS2; NbExp=3; IntAct=EBI-356254, EBI-741037; Q9UJV3-2 MID2; NbExp=3; IntAct=EBI-356254, EBI-10172526; Q5JR59 MTUS2; NbExp=4; IntAct=EBI-356254, EBI-742948; Q7Z3S9 NOTCH2NL; NbExp=3; IntAct=EBI-356254, EBI-945833; Q8WW24 TEKT4; NbExp=3; IntAct=EBI-356254, EBI-750487; Q13077 TRAF1; NbExp=3; IntAct=EBI-356254, EBI-359224; P36406 TRIM23; NbExp=3; IntAct=EBI-356254, EBI-740098; Q15654 TRIP6; NbExp=3; IntAct=EBI-356254, EBI-742327; 
# IntAct	P12236	64
# InterPro	IPR002067	Mit_carrier
# InterPro	IPR002113	Aden_trnslctor
# InterPro	IPR018108	Mitochondrial_sb/sol_carrier
# InterPro	IPR023395	Mt_carrier_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# KEGG_Pathway	ko05166	HTLV-I infection
# MIM	300151	gene
# MIM	403000	gene
# MISCELLANEOUS	ADT3_HUMAN	The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. 
# MISCELLANEOUS	The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity). {ECO	0000250}. 
# Organism	ADT3_HUMAN	Homo sapiens (Human)
# PIR	S03894	S03894
# PRINTS	PR00926	MITOCARRIER
# PRINTS	PR00927	ADPTRNSLCASE
# PROSITE	PS50920	SOLCAR; 3
# Pfam	PF00153	Mito_carr; 3
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-1268020	Mitochondrial protein import
# Reactome	R-HSA-168277	Influenza Virus Induced Apoptosis
# Reactome	R-HSA-180897	Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
# Reactome	R-HSA-422356	Regulation of insulin secretion
# RecName	ADT3_HUMAN	ADP/ATP translocase 3
# RecName	ADT3_HUMAN	ADP/ATP translocase 3, N-terminally processed
# RefSeq	NP_001627	NM_001636.3
# SIMILARITY	Belongs to the mitochondrial carrier (TC 2.A.29) family. {ECO	0000305}. 
# SIMILARITY	Contains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule	PRU00282}.
# SUBCELLULAR LOCATION	ADT3_HUMAN	Mitochondrion inner membrane; Multi-pass membrane protein. Note=The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria. {ECO 0000250}. 
# SUBUNIT	ADT3_HUMAN	Found in a complex with ARL2, ARL2BP and SLC25A6 (By similarity). Homodimer. Interacts with influenza A virus PB1-F2 protein and HIV-1 Vpr. {ECO 0000250, ECO 0000269|PubMed 16120388, ECO 0000269|PubMed 16201016}. 
# SUPFAM	SSF103506	SSF103506
# TCDB	2.A.29.1.10	the mitochondrial carrier (mc) family
# eggNOG	ENOG410XNW0	LUCA
# eggNOG	KOG0749	Eukaryota
BLAST	swissprot:ADT3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ADT3_HUMAN
BioCyc	ZFISH:ENSG00000169100-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000169100-MONOMER
COXPRESdb	293	http://coxpresdb.jp/data/gene/293.shtml
CleanEx	HS_SLC25A6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC25A6
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/0022-2836(89)90477-4	http://dx.doi.org/10.1016/0022-2836(89)90477-4
DOI	10.1016/j.mito.2004.06.012	http://dx.doi.org/10.1016/j.mito.2004.06.012
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1073/pnas.85.2.377	http://dx.doi.org/10.1073/pnas.85.2.377
DOI	10.1074/mcp.M111.015131	http://dx.doi.org/10.1074/mcp.M111.015131
DOI	10.1074/mcp.O113.027870	http://dx.doi.org/10.1074/mcp.O113.027870
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1196/annals.1299.022	http://dx.doi.org/10.1196/annals.1299.022
DOI	10.1371/journal.ppat.0010004	http://dx.doi.org/10.1371/journal.ppat.0010004
DrugBank	DB00720	http://www.drugbank.ca/drugs/DB00720
EMBL	AY007135	http://www.ebi.ac.uk/ena/data/view/AY007135
EMBL	BC007295	http://www.ebi.ac.uk/ena/data/view/BC007295
EMBL	BC007850	http://www.ebi.ac.uk/ena/data/view/BC007850
EMBL	BC008737	http://www.ebi.ac.uk/ena/data/view/BC008737
EMBL	BC008935	http://www.ebi.ac.uk/ena/data/view/BC008935
EMBL	BC014775	http://www.ebi.ac.uk/ena/data/view/BC014775
EMBL	BC031912	http://www.ebi.ac.uk/ena/data/view/BC031912
EMBL	J03592	http://www.ebi.ac.uk/ena/data/view/J03592
Ensembl	ENST00000381401	http://www.ensembl.org/id/ENST00000381401
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005744	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005744
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0031012	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031012
GO_function	GO:0005471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005471
GO_function	GO:0015207	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015207
GO_process	GO:0006626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006626
GO_process	GO:0006915	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006915
GO_process	GO:0046732	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046732
GO_process	GO:0050796	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050796
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0008219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
Gene3D	1.50.40.10	http://www.cathdb.info/version/latest/superfamily/1.50.40.10
GeneCards	SLC25A6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC25A6
GeneID	293	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=293
GeneTree	ENSGT00390000011543	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000011543
H-InvDB	HIX0034763	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0034763
HGNC	HGNC:10992	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10992
HOVERGEN	HBG108348	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108348&db=HOVERGEN
HPA	HPA060665	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA060665
InParanoid	P12236	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P12236
IntAct	P12236	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P12236*
InterPro	IPR002067	http://www.ebi.ac.uk/interpro/entry/IPR002067
InterPro	IPR002113	http://www.ebi.ac.uk/interpro/entry/IPR002113
InterPro	IPR018108	http://www.ebi.ac.uk/interpro/entry/IPR018108
InterPro	IPR023395	http://www.ebi.ac.uk/interpro/entry/IPR023395
Jabion	293	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=293
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:293	http://www.genome.jp/dbget-bin/www_bget?hsa:293
KEGG_Orthology	KO:K05863	http://www.genome.jp/dbget-bin/www_bget?KO:K05863
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
KEGG_Pathway	ko05166	http://www.genome.jp/kegg-bin/show_pathway?ko05166
MIM	300151	http://www.ncbi.nlm.nih.gov/omim/300151
MIM	403000	http://www.ncbi.nlm.nih.gov/omim/403000
MINT	MINT-1154461	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1154461
OMA	TRSHVIN	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TRSHVIN
OrthoDB	EOG091G0ULB	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0ULB
PRINTS	PR00926	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00926
PRINTS	PR00927	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00927
PROSITE	PS50920	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50920
PSORT	swissprot:ADT3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ADT3_HUMAN
PSORT-B	swissprot:ADT3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ADT3_HUMAN
PSORT2	swissprot:ADT3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ADT3_HUMAN
Pfam	PF00153	http://pfam.xfam.org/family/PF00153
PharmGKB	PA35868	http://www.pharmgkb.org/do/serve?objId=PA35868&objCls=Gene
Phobius	swissprot:ADT3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ADT3_HUMAN
PhylomeDB	P12236	http://phylomedb.org/?seqid=P12236
ProteinModelPortal	P12236	http://www.proteinmodelportal.org/query/uniprot/P12236
PubMed	15033708	http://www.ncbi.nlm.nih.gov/pubmed/15033708
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16120388	http://www.ncbi.nlm.nih.gov/pubmed/16120388
PubMed	16201016	http://www.ncbi.nlm.nih.gov/pubmed/16201016
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22223895	http://www.ncbi.nlm.nih.gov/pubmed/22223895
PubMed	24129315	http://www.ncbi.nlm.nih.gov/pubmed/24129315
PubMed	2541251	http://www.ncbi.nlm.nih.gov/pubmed/2541251
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	2829183	http://www.ncbi.nlm.nih.gov/pubmed/2829183
Reactome	R-HSA-1268020	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1268020
Reactome	R-HSA-168277	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-168277
Reactome	R-HSA-180897	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-180897
Reactome	R-HSA-422356	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-422356
RefSeq	NP_001627	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001627
SMR	P12236	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P12236
STRING	9606.ENSP00000370808	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000370808&targetmode=cogs
SUPFAM	SSF103506	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103506
TCDB	2.A.29.1.10	http://www.tcdb.org/search/result.php?tc=2.A.29.1.10
UniGene	Hs.350927	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.350927
UniGene	Hs.680626	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.680626
UniProtKB	ADT3_HUMAN	http://www.uniprot.org/uniprot/ADT3_HUMAN
UniProtKB-AC	P12236	http://www.uniprot.org/uniprot/P12236
charge	swissprot:ADT3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ADT3_HUMAN
eggNOG	ENOG410XNW0	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNW0
eggNOG	KOG0749	http://eggnogapi.embl.de/nog_data/html/tree/KOG0749
epestfind	swissprot:ADT3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ADT3_HUMAN
garnier	swissprot:ADT3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ADT3_HUMAN
helixturnhelix	swissprot:ADT3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ADT3_HUMAN
hmoment	swissprot:ADT3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ADT3_HUMAN
iep	swissprot:ADT3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ADT3_HUMAN
inforesidue	swissprot:ADT3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ADT3_HUMAN
neXtProt	NX_P12236	http://www.nextprot.org/db/entry/NX_P12236
octanol	swissprot:ADT3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ADT3_HUMAN
pepcoil	swissprot:ADT3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ADT3_HUMAN
pepdigest	swissprot:ADT3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ADT3_HUMAN
pepinfo	swissprot:ADT3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ADT3_HUMAN
pepnet	swissprot:ADT3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ADT3_HUMAN
pepstats	swissprot:ADT3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ADT3_HUMAN
pepwheel	swissprot:ADT3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ADT3_HUMAN
pepwindow	swissprot:ADT3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ADT3_HUMAN
sigcleave	swissprot:ADT3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ADT3_HUMAN
## Database	ID	URL or Descriptions
# AltName	VAS1L_HUMAN	Vacuolar proton pump subunit S1-like protein
# Ensembl	ENST00000380167	ENSP00000369513; ENSG00000205464
# Ensembl	ENST00000439350	ENSP00000391381; ENSG00000205464
# ExpressionAtlas	Q52LC2	baseline and differential
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0033180	proton-transporting V-type ATPase, V1 domain; IEA:InterPro.
# GO_function	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism; IEA:InterPro.
# GO_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
# GO_process	GO:0015991	ATP hydrolysis coupled proton transport; IEA:InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q52LC2	HS
# HGNC	HGNC:28091	ATP6AP1L
# InterPro	IPR008388	ATPase_V1-cplx_s1su
# InterPro	IPR024722	ATPase_V1_suS1_fam
# Organism	VAS1L_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12471	PTHR12471
# Pfam	PF05827	ATP-synt_S1
# Proteomes	UP000005640	Chromosome 5
# RecName	VAS1L_HUMAN	V-type proton ATPase subunit S1-like protein
# RefSeq	NP_001017971	NM_001017971.2
# RefSeq	XP_011542025	XM_011543723.2
# RefSeq	XP_016865530	XM_017010041.1
# RefSeq	XP_016865531	XM_017010042.1
# RefSeq	XP_016865532	XM_017010043.1
# RefSeq	XP_016865533	XM_017010044.1
# RefSeq	XP_016865534	XM_017010045.1
# RefSeq	XP_016865535	XM_017010046.1
# RefSeq	XP_016865536	XM_017010047.1
# SIMILARITY	Belongs to the vacuolar ATPase subunit S1 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	VAS1L_HUMAN	Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. 
# UCSC	uc003khv	human
# eggNOG	ENOG410XTHY	LUCA
# eggNOG	KOG3868	Eukaryota
BLAST	swissprot:VAS1L_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VAS1L_HUMAN
BioCyc	ZFISH:G66-31397-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31397-MONOMER
COXPRESdb	92270	http://coxpresdb.jp/data/gene/92270.shtml
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	BC093982	http://www.ebi.ac.uk/ena/data/view/BC093982
EMBL	BC112191	http://www.ebi.ac.uk/ena/data/view/BC112191
EMBL	CH471084	http://www.ebi.ac.uk/ena/data/view/CH471084
Ensembl	ENST00000380167	http://www.ensembl.org/id/ENST00000380167
Ensembl	ENST00000439350	http://www.ensembl.org/id/ENST00000439350
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0033180	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033180
GO_function	GO:0046933	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046933
GO_function	GO:0046961	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046961
GO_process	GO:0015991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015991
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ATP6AP1L	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP6AP1L
GeneID	92270	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=92270
GeneTree	ENSGT00530000063584	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063584
HGNC	HGNC:28091	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:28091
HOGENOM	HOG000154807	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000154807&db=HOGENOM6
HPA	HPA053771	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA053771
InParanoid	Q52LC2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q52LC2
InterPro	IPR008388	http://www.ebi.ac.uk/interpro/entry/IPR008388
InterPro	IPR024722	http://www.ebi.ac.uk/interpro/entry/IPR024722
Jabion	92270	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=92270
KEGG_Gene	hsa:92270	http://www.genome.jp/dbget-bin/www_bget?hsa:92270
OMA	MSSLWEV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MSSLWEV
OrthoDB	EOG091G0772	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0772
PANTHER	PTHR12471	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12471
PSORT	swissprot:VAS1L_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VAS1L_HUMAN
PSORT-B	swissprot:VAS1L_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VAS1L_HUMAN
PSORT2	swissprot:VAS1L_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VAS1L_HUMAN
Pfam	PF05827	http://pfam.xfam.org/family/PF05827
PharmGKB	PA164716384	http://www.pharmgkb.org/do/serve?objId=PA164716384&objCls=Gene
Phobius	swissprot:VAS1L_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VAS1L_HUMAN
PhylomeDB	Q52LC2	http://phylomedb.org/?seqid=Q52LC2
ProteinModelPortal	Q52LC2	http://www.proteinmodelportal.org/query/uniprot/Q52LC2
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
RefSeq	NP_001017971	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001017971
RefSeq	XP_011542025	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011542025
RefSeq	XP_016865530	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016865530
RefSeq	XP_016865531	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016865531
RefSeq	XP_016865532	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016865532
RefSeq	XP_016865533	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016865533
RefSeq	XP_016865534	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016865534
RefSeq	XP_016865535	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016865535
RefSeq	XP_016865536	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016865536
SMR	Q52LC2	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q52LC2
STRING	9606.ENSP00000369513	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000369513&targetmode=cogs
UCSC	uc003khv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003khv&org=rat
UniGene	Hs.729805	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.729805
UniProtKB	VAS1L_HUMAN	http://www.uniprot.org/uniprot/VAS1L_HUMAN
UniProtKB-AC	Q52LC2	http://www.uniprot.org/uniprot/Q52LC2
charge	swissprot:VAS1L_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VAS1L_HUMAN
eggNOG	ENOG410XTHY	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XTHY
eggNOG	KOG3868	http://eggnogapi.embl.de/nog_data/html/tree/KOG3868
epestfind	swissprot:VAS1L_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VAS1L_HUMAN
garnier	swissprot:VAS1L_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VAS1L_HUMAN
helixturnhelix	swissprot:VAS1L_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VAS1L_HUMAN
hmoment	swissprot:VAS1L_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VAS1L_HUMAN
iep	swissprot:VAS1L_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VAS1L_HUMAN
inforesidue	swissprot:VAS1L_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VAS1L_HUMAN
neXtProt	NX_Q52LC2	http://www.nextprot.org/db/entry/NX_Q52LC2
octanol	swissprot:VAS1L_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VAS1L_HUMAN
pepcoil	swissprot:VAS1L_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VAS1L_HUMAN
pepdigest	swissprot:VAS1L_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VAS1L_HUMAN
pepinfo	swissprot:VAS1L_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VAS1L_HUMAN
pepnet	swissprot:VAS1L_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VAS1L_HUMAN
pepstats	swissprot:VAS1L_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VAS1L_HUMAN
pepwheel	swissprot:VAS1L_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VAS1L_HUMAN
pepwindow	swissprot:VAS1L_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VAS1L_HUMAN
sigcleave	swissprot:VAS1L_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VAS1L_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNA7_HUMAN	Voltage-gated potassium channel subunit Kv1.7
# DOMAIN	KCNA7_HUMAN	The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. {ECO 0000250}. 
# DOMAIN	KCNA7_HUMAN	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. {ECO 0000250}. 
# DrugBank	DB06637	Dalfampridine
# Ensembl	ENST00000221444	ENSP00000221444; ENSG00000104848
# FUNCTION	KCNA7_HUMAN	Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity). {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IEA:InterPro.
# GO_component	GO:0016021	integral component of membrane; IBA:GO_Central.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; IBA:GO_Central.
# GO_process	GO:0051260	protein homooligomerization; IEA:InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# Gene3D	1.20.120.350	-; 1.
# Genevisible	Q96RP8	HS
# HGNC	HGNC:6226	KCNA7
# InterPro	IPR000210	BTB/POZ_dom
# InterPro	IPR003131	T1-type_BTB
# InterPro	IPR003968	K_chnl_volt-dep_Kv
# InterPro	IPR003972	K_chnl_volt-dep_Kv1
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR011333	SKP1/BTB/POZ
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko04040	Ion channels
# MIM	176268	gene
# Organism	KCNA7_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11537	PTHR11537; 2
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01491	KVCHANNEL
# PRINTS	PR01496	SHAKERCHANEL
# Pfam	PF00520	Ion_trans
# Pfam	PF02214	BTB_2
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# RecName	KCNA7_HUMAN	Potassium voltage-gated channel subfamily A member 7
# RefSeq	NP_114092	NM_031886.2
# SIMILARITY	Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.7/KCNA7 sub-subfamily. {ECO	0000305}.
# SMART	SM00225	BTB
# SUBCELLULAR LOCATION	KCNA7_HUMAN	Membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUBUNIT	Heterotetramer of potassium channel proteins. {ECO	0000250}. 
# SUPFAM	SSF54695	SSF54695
# TISSUE SPECIFICITY	KCNA7_HUMAN	Highly expressed in skeletal muscle, heart and kidney. {ECO 0000269|PubMed 11368907, ECO 0000269|PubMed 11896454}. 
# UCSC	uc002pmg	human
# eggNOG	COG1226	LUCA
# eggNOG	KOG1545	Eukaryota
BLAST	swissprot:KCNA7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNA7_HUMAN
BioCyc	ZFISH:ENSG00000104848-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000104848-MONOMER
COXPRESdb	3743	http://coxpresdb.jp/data/gene/3743.shtml
CleanEx	HS_KCNA7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNA7
DOI	10.1016/S0378-1119(01)00423-1	http://dx.doi.org/10.1016/S0378-1119(01)00423-1
DOI	10.1038/sj.ejhg.5200739	http://dx.doi.org/10.1038/sj.ejhg.5200739
DrugBank	DB06637	http://www.drugbank.ca/drugs/DB06637
EMBL	AF315818	http://www.ebi.ac.uk/ena/data/view/AF315818
EMBL	AJ310479	http://www.ebi.ac.uk/ena/data/view/AJ310479
EMBL	AY779768	http://www.ebi.ac.uk/ena/data/view/AY779768
Ensembl	ENST00000221444	http://www.ensembl.org/id/ENST00000221444
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	KCNA7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNA7
GeneID	3743	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3743
GeneTree	ENSGT00760000118846	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118846
HGNC	HGNC:6226	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6226
HOGENOM	HOG000231015	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231015&db=HOGENOM6
HOVERGEN	HBG052230	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052230&db=HOVERGEN
InParanoid	Q96RP8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96RP8
InterPro	IPR000210	http://www.ebi.ac.uk/interpro/entry/IPR000210
InterPro	IPR003131	http://www.ebi.ac.uk/interpro/entry/IPR003131
InterPro	IPR003968	http://www.ebi.ac.uk/interpro/entry/IPR003968
InterPro	IPR003972	http://www.ebi.ac.uk/interpro/entry/IPR003972
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR011333	http://www.ebi.ac.uk/interpro/entry/IPR011333
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	3743	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3743
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3743	http://www.genome.jp/dbget-bin/www_bget?hsa:3743
KEGG_Orthology	KO:K04880	http://www.genome.jp/dbget-bin/www_bget?KO:K04880
MIM	176268	http://www.ncbi.nlm.nih.gov/omim/176268
OMA	AMEPRCP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AMEPRCP
OrthoDB	EOG091G10NU	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G10NU
PANTHER	PTHR11537	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01491	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01491
PRINTS	PR01496	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01496
PSORT	swissprot:KCNA7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNA7_HUMAN
PSORT-B	swissprot:KCNA7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNA7_HUMAN
PSORT2	swissprot:KCNA7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNA7_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF02214	http://pfam.xfam.org/family/PF02214
PharmGKB	PA30023	http://www.pharmgkb.org/do/serve?objId=PA30023&objCls=Gene
Phobius	swissprot:KCNA7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNA7_HUMAN
PhylomeDB	Q96RP8	http://phylomedb.org/?seqid=Q96RP8
ProteinModelPortal	Q96RP8	http://www.proteinmodelportal.org/query/uniprot/Q96RP8
PubMed	11368907	http://www.ncbi.nlm.nih.gov/pubmed/11368907
PubMed	11896454	http://www.ncbi.nlm.nih.gov/pubmed/11896454
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
RefSeq	NP_114092	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_114092
SMART	SM00225	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225
SMR	Q96RP8	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q96RP8
STRING	9606.ENSP00000221444	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000221444&targetmode=cogs
SUPFAM	SSF54695	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54695
UCSC	uc002pmg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002pmg&org=rat
UniGene	Hs.306973	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.306973
UniProtKB	KCNA7_HUMAN	http://www.uniprot.org/uniprot/KCNA7_HUMAN
UniProtKB-AC	Q96RP8	http://www.uniprot.org/uniprot/Q96RP8
charge	swissprot:KCNA7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNA7_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG1545	http://eggnogapi.embl.de/nog_data/html/tree/KOG1545
epestfind	swissprot:KCNA7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNA7_HUMAN
garnier	swissprot:KCNA7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNA7_HUMAN
helixturnhelix	swissprot:KCNA7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNA7_HUMAN
hmoment	swissprot:KCNA7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNA7_HUMAN
iep	swissprot:KCNA7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNA7_HUMAN
inforesidue	swissprot:KCNA7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNA7_HUMAN
neXtProt	NX_Q96RP8	http://www.nextprot.org/db/entry/NX_Q96RP8
octanol	swissprot:KCNA7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNA7_HUMAN
pepcoil	swissprot:KCNA7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNA7_HUMAN
pepdigest	swissprot:KCNA7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNA7_HUMAN
pepinfo	swissprot:KCNA7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNA7_HUMAN
pepnet	swissprot:KCNA7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNA7_HUMAN
pepstats	swissprot:KCNA7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNA7_HUMAN
pepwheel	swissprot:KCNA7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNA7_HUMAN
pepwindow	swissprot:KCNA7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNA7_HUMAN
sigcleave	swissprot:KCNA7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNA7_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ACHG_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P07510-1; Sequence=Displayed; Name=2; IsoId=P07510-2; Sequence=VSP_055775; Note=No experimental confirmation available.; 
# BioGrid	107568	8
# CCDS	CCDS33400	-. [P07510-1]
# DISEASE	ACHG_HUMAN	Multiple pterygium syndrome, Escobar variant (EVMPS) [MIM 265000]  Non-lethal form of arthrogryposis multiplex congenita. It is an autosomal recessive condition characterized by excessive webbing (pterygia), congenital contractures (arthrogryposis), and scoliosis. Variable other features include intrauterine death, congenital respiratory distress, short stature, faciocranial dysmorphism, ptosis, low-set ears, arachnodactyly and cryptorchism in males. Congenital contractures are common and may be caused by reduced fetal movements at sensitive times of development. Possible causes of decreased fetal mobility include space constraints such as oligohydramnion, drugs, metabolic conditions or neuromuscular disorders including myasthenia gravis. {ECO 0000269|PubMed 16826520, ECO 0000269|PubMed 16826531}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ACHG_HUMAN	Multiple pterygium syndrome, lethal type (LMPS) [MIM 253290]  Multiple pterygia are found infrequently in children with arthrogryposis and in fetuses with fetal akinesia syndrome. In lethal multiple pterygium syndrome there is intrauterine growth retardation, multiple pterygia, and flexion contractures causing severe arthrogryposis and fetal akinesia. Subcutaneous edema can be severe, causing fetal hydrops with cystic hygroma and lung hypoplasia. Oligohydramnios and facial anomalies are frequent. {ECO 0000269|PubMed 16826520, ECO 0000269|PubMed 16826531}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00674	Galantamine
# Ensembl	ENST00000389492	ENSP00000374143; ENSG00000196811. [P07510-2]
# Ensembl	ENST00000389494	ENSP00000374145; ENSG00000196811. [P07510-1]
# FUNCTION	ACHG_HUMAN	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0005892	acetylcholine-gated channel complex; IBA:GO_Central.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0004889	acetylcholine-activated cation-selective channel activity; IEA:InterPro.
# GO_function	GO:0015267	channel activity; TAS:ProtInc.
# GO_function	GO:0015276	ligand-gated ion channel activity; TAS:Reactome.
# GO_function	GO:0015464	acetylcholine receptor activity; TAS:ProtInc.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006936	muscle contraction; TAS:ProtInc.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0007271	synaptic transmission, cholinergic; IBA:GO_Central.
# GO_process	GO:0007274	neuromuscular synaptic transmission; IBA:GO_Central.
# GO_process	GO:0035094	response to nicotine; IBA:GO_Central.
# GO_process	GO:0098655	cation transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.370	-; 2.
# Gene3D	2.70.170.10	-; 1.
# Genevisible	P07510	HS
# HGNC	HGNC:1967	CHRNG
# INTERACTION	ACHG_HUMAN	Q15323 KRT31; NbExp=3; IntAct=EBI-9008836, EBI-948001; P60409 KRTAP10-7; NbExp=3; IntAct=EBI-9008836, EBI-10172290; P60410 KRTAP10-8; NbExp=3; IntAct=EBI-9008836, EBI-10171774; P60411 KRTAP10-9; NbExp=3; IntAct=EBI-9008836, EBI-10172052; Q7Z3S9 NOTCH2NL; NbExp=3; IntAct=EBI-9008836, EBI-945833; 
# IntAct	P07510	11
# InterPro	IPR002394	Nicotinic_acetylcholine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# InterPro	IPR027361	Acetylcholine_rcpt_TM
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00986	[Developmental disorder] Multiple pterygium syndrome, Escobar variant (EVMPS)
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# MIM	100730	gene
# MIM	253290	phenotype
# MIM	265000	phenotype
# Organism	ACHG_HUMAN	Homo sapiens (Human)
# Orphanet	2990	Autosomal recessive multiple pterygium syndrome
# Orphanet	33108	Lethal multiple pterygium syndrome
# PANTHER	PTHR18945	PTHR18945; 2
# PIR	A23261	A23261
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00254	NICOTINICR
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-629587	Highly sodium permeable acetylcholine nicotinic receptors
# RecName	ACHG_HUMAN	Acetylcholine receptor subunit gamma
# RefSeq	NP_005190	NM_005199.4. [P07510-1]
# SEQUENCE CAUTION	Sequence=AAY24103.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAA25861.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Gamma/CHRNG sub-subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	ACHG_HUMAN	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	ACHG_HUMAN	Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TCDB	1.A.9.1	the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family
# UCSC	uc002vsx	human. [P07510-1]
# eggNOG	ENOG410XQGR	LUCA
# eggNOG	KOG3645	Eukaryota
BLAST	swissprot:ACHG_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ACHG_HUMAN
BioCyc	ZFISH:G66-31310-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31310-MONOMER
COXPRESdb	1146	http://coxpresdb.jp/data/gene/1146.shtml
CleanEx	HS_CHRNG	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CHRNG
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1086/506256	http://dx.doi.org/10.1086/506256
DOI	10.1086/506257	http://dx.doi.org/10.1086/506257
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1432-1033.1985.tb08614.x	http://dx.doi.org/10.1111/j.1432-1033.1985.tb08614.x
DOI	10.1111/j.1432-1033.1993.tb18027.x	http://dx.doi.org/10.1111/j.1432-1033.1993.tb18027.x
DrugBank	DB00674	http://www.drugbank.ca/drugs/DB00674
EMBL	AC092165	http://www.ebi.ac.uk/ena/data/view/AC092165
EMBL	AK125362	http://www.ebi.ac.uk/ena/data/view/AK125362
EMBL	BC111802	http://www.ebi.ac.uk/ena/data/view/BC111802
EMBL	X01715	http://www.ebi.ac.uk/ena/data/view/X01715
EMBL	X01716	http://www.ebi.ac.uk/ena/data/view/X01716
EMBL	X01717	http://www.ebi.ac.uk/ena/data/view/X01717
EMBL	X01718	http://www.ebi.ac.uk/ena/data/view/X01718
EMBL	X01719	http://www.ebi.ac.uk/ena/data/view/X01719
EMBL	X01720	http://www.ebi.ac.uk/ena/data/view/X01720
EMBL	X01721	http://www.ebi.ac.uk/ena/data/view/X01721
EMBL	X04759	http://www.ebi.ac.uk/ena/data/view/X04759
Ensembl	ENST00000389492	http://www.ensembl.org/id/ENST00000389492
Ensembl	ENST00000389494	http://www.ensembl.org/id/ENST00000389494
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005892	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005892
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0004889	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004889
GO_function	GO:0015267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015267
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_function	GO:0015464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015464
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006936	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006936
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007271
GO_process	GO:0007274	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007274
GO_process	GO:0035094	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035094
GO_process	GO:0098655	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098655
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.370	http://www.cathdb.info/version/latest/superfamily/1.20.120.370
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	CHRNG	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CHRNG
GeneID	1146	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1146
GeneTree	ENSGT00760000118930	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118930
HGNC	HGNC:1967	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1967
HOGENOM	HOG000006757	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006757&db=HOGENOM6
HOVERGEN	HBG003756	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003756&db=HOVERGEN
InParanoid	P07510	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07510
IntAct	P07510	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07510*
InterPro	IPR002394	http://www.ebi.ac.uk/interpro/entry/IPR002394
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
InterPro	IPR027361	http://www.ebi.ac.uk/interpro/entry/IPR027361
Jabion	1146	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1146
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00986	http://www.genome.jp/dbget-bin/www_bget?H00986
KEGG_Gene	hsa:1146	http://www.genome.jp/dbget-bin/www_bget?hsa:1146
KEGG_Orthology	KO:K04818	http://www.genome.jp/dbget-bin/www_bget?KO:K04818
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
MIM	100730	http://www.ncbi.nlm.nih.gov/omim/100730
MIM	253290	http://www.ncbi.nlm.nih.gov/omim/253290
MIM	265000	http://www.ncbi.nlm.nih.gov/omim/265000
OMA	EEWFLVG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EEWFLVG
Orphanet	2990	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=2990
Orphanet	33108	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=33108
OrthoDB	EOG091G0R20	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0R20
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00254	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00254
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:ACHG_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ACHG_HUMAN
PSORT-B	swissprot:ACHG_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ACHG_HUMAN
PSORT2	swissprot:ACHG_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ACHG_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA26499	http://www.pharmgkb.org/do/serve?objId=PA26499&objCls=Gene
Phobius	swissprot:ACHG_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ACHG_HUMAN
PhylomeDB	P07510	http://phylomedb.org/?seqid=P07510
ProteinModelPortal	P07510	http://www.proteinmodelportal.org/query/uniprot/P07510
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	16826520	http://www.ncbi.nlm.nih.gov/pubmed/16826520
PubMed	16826531	http://www.ncbi.nlm.nih.gov/pubmed/16826531
PubMed	3967651	http://www.ncbi.nlm.nih.gov/pubmed/3967651
PubMed	7688301	http://www.ncbi.nlm.nih.gov/pubmed/7688301
Reactome	R-HSA-629587	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-629587
RefSeq	NP_005190	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005190
STRING	9606.ENSP00000374145	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000374145&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TCDB	1.A.9.1	http://www.tcdb.org/search/result.php?tc=1.A.9.1
UCSC	uc002vsx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002vsx&org=rat
UniGene	Hs.248101	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.248101
UniProtKB	ACHG_HUMAN	http://www.uniprot.org/uniprot/ACHG_HUMAN
UniProtKB-AC	P07510	http://www.uniprot.org/uniprot/P07510
charge	swissprot:ACHG_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ACHG_HUMAN
eggNOG	ENOG410XQGR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQGR
eggNOG	KOG3645	http://eggnogapi.embl.de/nog_data/html/tree/KOG3645
epestfind	swissprot:ACHG_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ACHG_HUMAN
garnier	swissprot:ACHG_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ACHG_HUMAN
helixturnhelix	swissprot:ACHG_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACHG_HUMAN
hmoment	swissprot:ACHG_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ACHG_HUMAN
iep	swissprot:ACHG_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ACHG_HUMAN
inforesidue	swissprot:ACHG_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ACHG_HUMAN
neXtProt	NX_P07510	http://www.nextprot.org/db/entry/NX_P07510
octanol	swissprot:ACHG_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ACHG_HUMAN
pepcoil	swissprot:ACHG_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ACHG_HUMAN
pepdigest	swissprot:ACHG_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ACHG_HUMAN
pepinfo	swissprot:ACHG_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ACHG_HUMAN
pepnet	swissprot:ACHG_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ACHG_HUMAN
pepstats	swissprot:ACHG_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ACHG_HUMAN
pepwheel	swissprot:ACHG_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ACHG_HUMAN
pepwindow	swissprot:ACHG_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ACHG_HUMAN
sigcleave	swissprot:ACHG_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ACHG_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SO1A2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=OATP1a; IsoId=P46721-1; Sequence=Displayed; Name=OATP1b; IsoId=P46721-2; Sequence=VSP_006130, VSP_006131, VSP_006132; 
# AltName	SO1A2_HUMAN	OATP-A
# AltName	SO1A2_HUMAN	Organic anion-transporting polypeptide 1
# AltName	SO1A2_HUMAN	Sodium-independent organic anion transporter
# AltName	SO1A2_HUMAN	Solute carrier family 21 member 3
# CCDS	CCDS8686	-. [P46721-1]
# CDD	cd06174	MFS
# ChiTaRS	SLCO1A2	human
# DrugBank	DB00091	Cyclosporine
# DrugBank	DB00175	Pravastatin
# DrugBank	DB00199	Erythromycin
# DrugBank	DB00220	Nelfinavir
# DrugBank	DB00224	Indinavir
# DrugBank	DB00227	Lovastatin
# DrugBank	DB00279	Liothyronine
# DrugBank	DB00286	Conjugated Estrogens
# DrugBank	DB00291	Chlorambucil
# DrugBank	DB00328	Indomethacin
# DrugBank	DB00345	Aminohippurate
# DrugBank	DB00390	Digoxin
# DrugBank	DB00421	Spironolactone
# DrugBank	DB00451	Levothyroxine
# DrugBank	DB00468	Quinine
# DrugBank	DB00503	Ritonavir
# DrugBank	DB00563	Methotrexate
# DrugBank	DB00584	Enalapril
# DrugBank	DB00624	Testosterone
# DrugBank	DB00635	Prednisone
# DrugBank	DB00641	Simvastatin
# DrugBank	DB00655	Estrone
# DrugBank	DB00661	Verapamil
# DrugBank	DB00669	Sumatriptan
# DrugBank	DB00728	Rocuronium
# DrugBank	DB00741	Hydrocortisone
# DrugBank	DB00783	Estradiol
# DrugBank	DB00788	Naproxen
# DrugBank	DB00860	Prednisolone
# DrugBank	DB00887	Bumetanide
# DrugBank	DB00908	Quinidine
# DrugBank	DB00917	Dinoprostone
# DrugBank	DB00950	Fexofenadine
# DrugBank	DB01009	Ketoprofen
# DrugBank	DB01016	Glyburide
# DrugBank	DB01026	Ketoconazole
# DrugBank	DB01032	Probenecid
# DrugBank	DB01045	Rifampicin
# DrugBank	DB01050	Ibuprofen
# DrugBank	DB01076	Atorvastatin
# DrugBank	DB01092	Ouabain
# DrugBank	DB01098	Rosuvastatin
# DrugBank	DB01124	Tolbutamide
# DrugBank	DB01183	Naloxone
# DrugBank	DB01232	Saquinavir
# DrugBank	DB01234	Dexamethasone
# DrugBank	DB01396	Digitoxin
# DrugBank	DB01583	Liotrix
# DrugBank	DB01586	Ursodeoxycholic acid
# DrugBank	DB02659	Cholic Acid
# DrugBank	DB03619	Deoxycholic Acid
# DrugBank	DB04573	Estriol
# DrugBank	DB06710	Methyltestosterone
# DrugBank	DB08834	Tauroursodeoxycholic acid
# DrugBank	DB08893	Mirabegron
# Ensembl	ENST00000307378	ENSP00000305974; ENSG00000084453. [P46721-1]
# ExpressionAtlas	P46721	baseline and differential
# FUNCTION	SO1A2_HUMAN	Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin. {ECO 0000250, ECO 0000269|PubMed 17301733}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0008514	organic anion transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0015125	bile acid transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015347	sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0008206	bile acid metabolic process; IBA:GO_Central.
# GO_process	GO:0015711	organic anion transport; TAS:ProtInc.
# GO_process	GO:0015721	bile acid and bile salt transport; TAS:Reactome.
# GO_process	GO:0043252	sodium-independent organic anion transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0044281	small molecule metabolic process
# Genevisible	P46721	HS
# HGNC	HGNC:10956	SLCO1A2
# InterPro	IPR002350	Kazal_dom
# InterPro	IPR004156	OA_transporter
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04976	Bile secretion
# MIM	602883	gene
# Organism	SO1A2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11388	PTHR11388
# PROSITE	PS50850	MFS
# PROSITE	PS51465	KAZAL_2
# Pfam	PF03137	OATP
# Pfam	PF07648	Kazal_2
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-159418	Recycling of bile acids and salts
# Reactome	R-HSA-879518	Transport of organic anions
# RecName	SO1A2_HUMAN	Solute carrier organic anion transporter family member 1A2
# RefSeq	NP_066580	NM_021094.3. [P46721-1]
# RefSeq	NP_602307	NM_134431.3. [P46721-1]
# RefSeq	XP_005253531	XM_005253474.3. [P46721-1]
# RefSeq	XP_011519120	XM_011520818.1. [P46721-1]
# RefSeq	XP_011519121	XM_011520819.1. [P46721-1]
# SIMILARITY	Belongs to the organo anion transporter (TC 2.A.60) family. {ECO	0000305}. 
# SIMILARITY	Contains 1 Kazal-like domain. {ECO:0000255|PROSITE- ProRule	PRU00798}.
# SUBCELLULAR LOCATION	SO1A2_HUMAN	Cell membrane; Multi-pass membrane protein. 
# SUPFAM	SSF103473	SSF103473; 3
# TCDB	2.A.60.1.14	the organo anion transporter (oat) family
# TIGRFAMs	TIGR00805	oat
# UCSC	uc001res	human. [P46721-1]
# eggNOG	ENOG410XRSF	LUCA
# eggNOG	KOG3626	Eukaryota
BLAST	swissprot:SO1A2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SO1A2_HUMAN
BioCyc	ZFISH:ENSG00000084453-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000084453-MONOMER
COXPRESdb	6579	http://coxpresdb.jp/data/gene/6579.shtml
CleanEx	HS_SLCO1A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLCO1A2
DOI	10.1016/0016-5085(95)90588-X	http://dx.doi.org/10.1016/0016-5085(95)90588-X
DOI	10.1038/sj.clpt.6100104	http://dx.doi.org/10.1038/sj.clpt.6100104
DOI	10.1074/jbc.M001448200	http://dx.doi.org/10.1074/jbc.M001448200
DOI	10.1074/jbc.M411092200	http://dx.doi.org/10.1074/jbc.M411092200
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1128/MCB.21.6.1973-1985.2001	http://dx.doi.org/10.1128/MCB.21.6.1973-1985.2001
DrugBank	DB00091	http://www.drugbank.ca/drugs/DB00091
DrugBank	DB00175	http://www.drugbank.ca/drugs/DB00175
DrugBank	DB00199	http://www.drugbank.ca/drugs/DB00199
DrugBank	DB00220	http://www.drugbank.ca/drugs/DB00220
DrugBank	DB00224	http://www.drugbank.ca/drugs/DB00224
DrugBank	DB00227	http://www.drugbank.ca/drugs/DB00227
DrugBank	DB00279	http://www.drugbank.ca/drugs/DB00279
DrugBank	DB00286	http://www.drugbank.ca/drugs/DB00286
DrugBank	DB00291	http://www.drugbank.ca/drugs/DB00291
DrugBank	DB00328	http://www.drugbank.ca/drugs/DB00328
DrugBank	DB00345	http://www.drugbank.ca/drugs/DB00345
DrugBank	DB00390	http://www.drugbank.ca/drugs/DB00390
DrugBank	DB00421	http://www.drugbank.ca/drugs/DB00421
DrugBank	DB00451	http://www.drugbank.ca/drugs/DB00451
DrugBank	DB00468	http://www.drugbank.ca/drugs/DB00468
DrugBank	DB00503	http://www.drugbank.ca/drugs/DB00503
DrugBank	DB00563	http://www.drugbank.ca/drugs/DB00563
DrugBank	DB00584	http://www.drugbank.ca/drugs/DB00584
DrugBank	DB00624	http://www.drugbank.ca/drugs/DB00624
DrugBank	DB00635	http://www.drugbank.ca/drugs/DB00635
DrugBank	DB00641	http://www.drugbank.ca/drugs/DB00641
DrugBank	DB00655	http://www.drugbank.ca/drugs/DB00655
DrugBank	DB00661	http://www.drugbank.ca/drugs/DB00661
DrugBank	DB00669	http://www.drugbank.ca/drugs/DB00669
DrugBank	DB00728	http://www.drugbank.ca/drugs/DB00728
DrugBank	DB00741	http://www.drugbank.ca/drugs/DB00741
DrugBank	DB00783	http://www.drugbank.ca/drugs/DB00783
DrugBank	DB00788	http://www.drugbank.ca/drugs/DB00788
DrugBank	DB00860	http://www.drugbank.ca/drugs/DB00860
DrugBank	DB00887	http://www.drugbank.ca/drugs/DB00887
DrugBank	DB00908	http://www.drugbank.ca/drugs/DB00908
DrugBank	DB00917	http://www.drugbank.ca/drugs/DB00917
DrugBank	DB00950	http://www.drugbank.ca/drugs/DB00950
DrugBank	DB01009	http://www.drugbank.ca/drugs/DB01009
DrugBank	DB01016	http://www.drugbank.ca/drugs/DB01016
DrugBank	DB01026	http://www.drugbank.ca/drugs/DB01026
DrugBank	DB01032	http://www.drugbank.ca/drugs/DB01032
DrugBank	DB01045	http://www.drugbank.ca/drugs/DB01045
DrugBank	DB01050	http://www.drugbank.ca/drugs/DB01050
DrugBank	DB01076	http://www.drugbank.ca/drugs/DB01076
DrugBank	DB01092	http://www.drugbank.ca/drugs/DB01092
DrugBank	DB01098	http://www.drugbank.ca/drugs/DB01098
DrugBank	DB01124	http://www.drugbank.ca/drugs/DB01124
DrugBank	DB01183	http://www.drugbank.ca/drugs/DB01183
DrugBank	DB01232	http://www.drugbank.ca/drugs/DB01232
DrugBank	DB01234	http://www.drugbank.ca/drugs/DB01234
DrugBank	DB01396	http://www.drugbank.ca/drugs/DB01396
DrugBank	DB01583	http://www.drugbank.ca/drugs/DB01583
DrugBank	DB01586	http://www.drugbank.ca/drugs/DB01586
DrugBank	DB02659	http://www.drugbank.ca/drugs/DB02659
DrugBank	DB03619	http://www.drugbank.ca/drugs/DB03619
DrugBank	DB04573	http://www.drugbank.ca/drugs/DB04573
DrugBank	DB06710	http://www.drugbank.ca/drugs/DB06710
DrugBank	DB08834	http://www.drugbank.ca/drugs/DB08834
DrugBank	DB08893	http://www.drugbank.ca/drugs/DB08893
EMBL	AF085224	http://www.ebi.ac.uk/ena/data/view/AF085224
EMBL	AF279784	http://www.ebi.ac.uk/ena/data/view/AF279784
EMBL	AJ400735	http://www.ebi.ac.uk/ena/data/view/AJ400735
EMBL	AJ400736	http://www.ebi.ac.uk/ena/data/view/AJ400736
EMBL	AJ400737	http://www.ebi.ac.uk/ena/data/view/AJ400737
EMBL	AJ400738	http://www.ebi.ac.uk/ena/data/view/AJ400738
EMBL	AJ400739	http://www.ebi.ac.uk/ena/data/view/AJ400739
EMBL	AJ400740	http://www.ebi.ac.uk/ena/data/view/AJ400740
EMBL	AJ400741	http://www.ebi.ac.uk/ena/data/view/AJ400741
EMBL	AJ400742	http://www.ebi.ac.uk/ena/data/view/AJ400742
EMBL	AJ400743	http://www.ebi.ac.uk/ena/data/view/AJ400743
EMBL	AJ400744	http://www.ebi.ac.uk/ena/data/view/AJ400744
EMBL	AJ400745	http://www.ebi.ac.uk/ena/data/view/AJ400745
EMBL	AJ400746	http://www.ebi.ac.uk/ena/data/view/AJ400746
EMBL	AJ400747	http://www.ebi.ac.uk/ena/data/view/AJ400747
EMBL	AJ400748	http://www.ebi.ac.uk/ena/data/view/AJ400748
EMBL	U21943	http://www.ebi.ac.uk/ena/data/view/U21943
EMBL	Y08062	http://www.ebi.ac.uk/ena/data/view/Y08062
Ensembl	ENST00000307378	http://www.ensembl.org/id/ENST00000307378
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0008514	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008514
GO_function	GO:0015125	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015125
GO_function	GO:0015347	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015347
GO_process	GO:0008206	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008206
GO_process	GO:0015711	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015711
GO_process	GO:0015721	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015721
GO_process	GO:0043252	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043252
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GeneCards	SLCO1A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLCO1A2
GeneID	6579	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6579
GeneTree	ENSGT00760000119014	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119014
HGNC	HGNC:10956	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10956
HOGENOM	HOG000231269	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231269&db=HOGENOM6
HOVERGEN	HBG063896	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG063896&db=HOVERGEN
InParanoid	P46721	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46721
IntAct	P46721	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P46721*
InterPro	IPR002350	http://www.ebi.ac.uk/interpro/entry/IPR002350
InterPro	IPR004156	http://www.ebi.ac.uk/interpro/entry/IPR004156
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	6579	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6579
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6579	http://www.genome.jp/dbget-bin/www_bget?hsa:6579
KEGG_Orthology	KO:K03460	http://www.genome.jp/dbget-bin/www_bget?KO:K03460
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
MIM	602883	http://www.ncbi.nlm.nih.gov/omim/602883
OMA	DCNCPSK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DCNCPSK
OrthoDB	EOG091G08QD	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08QD
PANTHER	PTHR11388	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11388
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PROSITE	PS51465	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51465
PSORT	swissprot:SO1A2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SO1A2_HUMAN
PSORT-B	swissprot:SO1A2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SO1A2_HUMAN
PSORT2	swissprot:SO1A2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SO1A2_HUMAN
Pfam	PF03137	http://pfam.xfam.org/family/PF03137
Pfam	PF07648	http://pfam.xfam.org/family/PF07648
PharmGKB	PA328	http://www.pharmgkb.org/do/serve?objId=PA328&objCls=Gene
Phobius	swissprot:SO1A2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SO1A2_HUMAN
PhylomeDB	P46721	http://phylomedb.org/?seqid=P46721
ProteinModelPortal	P46721	http://www.proteinmodelportal.org/query/uniprot/P46721
PubMed	10779507	http://www.ncbi.nlm.nih.gov/pubmed/10779507
PubMed	11238933	http://www.ncbi.nlm.nih.gov/pubmed/11238933
PubMed	15632119	http://www.ncbi.nlm.nih.gov/pubmed/15632119
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	17301733	http://www.ncbi.nlm.nih.gov/pubmed/17301733
PubMed	7557095	http://www.ncbi.nlm.nih.gov/pubmed/7557095
Reactome	R-HSA-159418	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-159418
Reactome	R-HSA-879518	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-879518
RefSeq	NP_066580	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_066580
RefSeq	NP_602307	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_602307
RefSeq	XP_005253531	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005253531
RefSeq	XP_011519120	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011519120
RefSeq	XP_011519121	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011519121
STRING	9606.ENSP00000305974	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000305974&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.60.1.14	http://www.tcdb.org/search/result.php?tc=2.A.60.1.14
TIGRFAMs	TIGR00805	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00805
UCSC	uc001res	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001res&org=rat
UniGene	Hs.46440	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.46440
UniProtKB	SO1A2_HUMAN	http://www.uniprot.org/uniprot/SO1A2_HUMAN
UniProtKB-AC	P46721	http://www.uniprot.org/uniprot/P46721
charge	swissprot:SO1A2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SO1A2_HUMAN
eggNOG	ENOG410XRSF	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRSF
eggNOG	KOG3626	http://eggnogapi.embl.de/nog_data/html/tree/KOG3626
epestfind	swissprot:SO1A2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SO1A2_HUMAN
garnier	swissprot:SO1A2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SO1A2_HUMAN
helixturnhelix	swissprot:SO1A2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SO1A2_HUMAN
hmoment	swissprot:SO1A2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SO1A2_HUMAN
iep	swissprot:SO1A2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SO1A2_HUMAN
inforesidue	swissprot:SO1A2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SO1A2_HUMAN
neXtProt	NX_P46721	http://www.nextprot.org/db/entry/NX_P46721
octanol	swissprot:SO1A2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SO1A2_HUMAN
pepcoil	swissprot:SO1A2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SO1A2_HUMAN
pepdigest	swissprot:SO1A2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SO1A2_HUMAN
pepinfo	swissprot:SO1A2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SO1A2_HUMAN
pepnet	swissprot:SO1A2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SO1A2_HUMAN
pepstats	swissprot:SO1A2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SO1A2_HUMAN
pepwheel	swissprot:SO1A2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SO1A2_HUMAN
pepwindow	swissprot:SO1A2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SO1A2_HUMAN
sigcleave	swissprot:SO1A2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SO1A2_HUMAN
## Database	ID	URL or Descriptions
# AltName	MOT2_HUMAN	Solute carrier family 16 member 7
# BioGrid	114629	2
# CDD	cd06174	MFS
# DrugBank	DB00119	Pyruvic acid
# DrugBank	DB01032	Probenecid
# DrugBank	DB01440	Gamma Hydroxybutyric Acid
# DrugBank	DB04398	Lactic Acid
# DrugBank	DB04552	Niflumic Acid
# Ensembl	ENST00000261187	ENSP00000261187; ENSG00000118596
# Ensembl	ENST00000547379	ENSP00000448071; ENSG00000118596
# Ensembl	ENST00000552024	ENSP00000448742; ENSG00000118596
# Ensembl	ENST00000552432	ENSP00000449547; ENSG00000118596
# ExpressionAtlas	O60669	baseline and differential
# FUNCTION	MOT2_HUMAN	Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter. {ECO 0000269|PubMed 9786900}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_function	GO:0005477	pyruvate secondary active transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0008028	monocarboxylic acid transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015129	lactate transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_function	GO:0050833	pyruvate transmembrane transporter activity; IDA:UniProtKB.
# GO_process	GO:0035873	lactate transmembrane transport; IMP:UniProtKB.
# GO_process	GO:0035879	plasma membrane lactate transport; IBA:GO_Central.
# GO_process	GO:1901475	pyruvate transmembrane transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	O60669	HS
# HGNC	HGNC:10928	SLC16A7
# IntAct	O60669	2
# InterPro	IPR004743	MCT
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# InterPro	IPR027178	MCT2
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	603654	gene
# Organism	MOT2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11360:SF25	PTHR11360:SF25
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-433692	Proton-coupled monocarboxylate transport
# RecName	MOT2_HUMAN	Monocarboxylate transporter 2
# RefSeq	NP_001257551	NM_001270622.1
# RefSeq	NP_001257552	NM_001270623.1
# RefSeq	NP_004722	NM_004731.4
# RefSeq	XP_005269288	XM_005269231.4
# SIMILARITY	Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	MOT2_HUMAN	Cell membrane {ECO 0000269|PubMed 15505343, ECO 0000269|PubMed 9786900}; Multi-pass membrane protein {ECO 0000269|PubMed 15505343, ECO 0000269|PubMed 9786900}. 
# SUBUNIT	Interacts with GRID2IP. {ECO	0000250}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.13	the major facilitator superfamily (mfs)
# TIGRFAMs	TIGR00892	2A0113
# TISSUE SPECIFICITY	Detected in heart and in blood lymphocytes and monocytes (at protein level). High expression in testis, moderate to low in spleen, heart, kidney, pancreas, skeletal muscle, brain and Leukocyte. Restricted expression in normal tissues, but widely expressed in cancer cells. {ECO:0000269|PubMed	15505343}. 
# UCSC	uc001sqs	human
# eggNOG	ENOG410IMVS	Eukaryota
# eggNOG	ENOG4111F0K	LUCA
BLAST	swissprot:MOT2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MOT2_HUMAN
BioCyc	ZFISH:ENSG00000118596-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000118596-MONOMER
COXPRESdb	9194	http://coxpresdb.jp/data/gene/9194.shtml
CleanEx	HS_SLC16A7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC16A7
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.273.44.28959	http://dx.doi.org/10.1074/jbc.273.44.28959
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1369/jhc.4A6306.2004	http://dx.doi.org/10.1369/jhc.4A6306.2004
DrugBank	DB00119	http://www.drugbank.ca/drugs/DB00119
DrugBank	DB01032	http://www.drugbank.ca/drugs/DB01032
DrugBank	DB01440	http://www.drugbank.ca/drugs/DB01440
DrugBank	DB04398	http://www.drugbank.ca/drugs/DB04398
DrugBank	DB04552	http://www.drugbank.ca/drugs/DB04552
EMBL	AC079905	http://www.ebi.ac.uk/ena/data/view/AC079905
EMBL	AF049608	http://www.ebi.ac.uk/ena/data/view/AF049608
EMBL	AF058056	http://www.ebi.ac.uk/ena/data/view/AF058056
EMBL	AK313345	http://www.ebi.ac.uk/ena/data/view/AK313345
EMBL	BC030693	http://www.ebi.ac.uk/ena/data/view/BC030693
EMBL	CH471054	http://www.ebi.ac.uk/ena/data/view/CH471054
Ensembl	ENST00000261187	http://www.ensembl.org/id/ENST00000261187
Ensembl	ENST00000547379	http://www.ensembl.org/id/ENST00000547379
Ensembl	ENST00000552024	http://www.ensembl.org/id/ENST00000552024
Ensembl	ENST00000552432	http://www.ensembl.org/id/ENST00000552432
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005477	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005477
GO_function	GO:0008028	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008028
GO_function	GO:0015129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015129
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_function	GO:0050833	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050833
GO_process	GO:0035873	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035873
GO_process	GO:0035879	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035879
GO_process	GO:1901475	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901475
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC16A7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC16A7
GeneID	9194	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9194
GeneTree	ENSGT00760000118926	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118926
H-InvDB	HIX0010769	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0010769
HGNC	HGNC:10928	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10928
HOGENOM	HOG000280688	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280688&db=HOGENOM6
HOVERGEN	HBG006384	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006384&db=HOVERGEN
HPA	HPA005911	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA005911
InParanoid	O60669	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O60669
IntAct	O60669	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O60669*
InterPro	IPR004743	http://www.ebi.ac.uk/interpro/entry/IPR004743
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
InterPro	IPR027178	http://www.ebi.ac.uk/interpro/entry/IPR027178
Jabion	9194	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9194
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:9194	http://www.genome.jp/dbget-bin/www_bget?hsa:9194
KEGG_Orthology	KO:K08184	http://www.genome.jp/dbget-bin/www_bget?KO:K08184
MIM	603654	http://www.ncbi.nlm.nih.gov/omim/603654
OMA	QYKYMYL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QYKYMYL
OrthoDB	EOG091G05SW	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05SW
PANTHER	PTHR11360:SF25	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11360:SF25
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:MOT2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MOT2_HUMAN
PSORT-B	swissprot:MOT2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MOT2_HUMAN
PSORT2	swissprot:MOT2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MOT2_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA35819	http://www.pharmgkb.org/do/serve?objId=PA35819&objCls=Gene
Phobius	swissprot:MOT2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MOT2_HUMAN
PhylomeDB	O60669	http://phylomedb.org/?seqid=O60669
ProteinModelPortal	O60669	http://www.proteinmodelportal.org/query/uniprot/O60669
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15505343	http://www.ncbi.nlm.nih.gov/pubmed/15505343
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	9786900	http://www.ncbi.nlm.nih.gov/pubmed/9786900
Reactome	R-HSA-433692	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-433692
RefSeq	NP_001257551	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001257551
RefSeq	NP_001257552	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001257552
RefSeq	NP_004722	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004722
RefSeq	XP_005269288	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005269288
STRING	9606.ENSP00000261187	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000261187&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.13	http://www.tcdb.org/search/result.php?tc=2.A.1.13
TIGRFAMs	TIGR00892	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00892
UCSC	uc001sqs	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001sqs&org=rat
UniGene	Hs.439643	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.439643
UniGene	Hs.88156	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.88156
UniProtKB	MOT2_HUMAN	http://www.uniprot.org/uniprot/MOT2_HUMAN
UniProtKB-AC	O60669	http://www.uniprot.org/uniprot/O60669
charge	swissprot:MOT2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MOT2_HUMAN
eggNOG	ENOG410IMVS	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IMVS
eggNOG	ENOG4111F0K	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111F0K
epestfind	swissprot:MOT2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MOT2_HUMAN
garnier	swissprot:MOT2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MOT2_HUMAN
helixturnhelix	swissprot:MOT2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MOT2_HUMAN
hmoment	swissprot:MOT2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MOT2_HUMAN
iep	swissprot:MOT2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MOT2_HUMAN
inforesidue	swissprot:MOT2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MOT2_HUMAN
neXtProt	NX_O60669	http://www.nextprot.org/db/entry/NX_O60669
octanol	swissprot:MOT2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MOT2_HUMAN
pepcoil	swissprot:MOT2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MOT2_HUMAN
pepdigest	swissprot:MOT2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MOT2_HUMAN
pepinfo	swissprot:MOT2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MOT2_HUMAN
pepnet	swissprot:MOT2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MOT2_HUMAN
pepstats	swissprot:MOT2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MOT2_HUMAN
pepwheel	swissprot:MOT2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MOT2_HUMAN
pepwindow	swissprot:MOT2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MOT2_HUMAN
sigcleave	swissprot:MOT2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MOT2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	MCATL_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8N8R3-1; Sequence=Displayed; Name=2; IsoId=Q8N8R3-2; Sequence=VSP_046286, VSP_046287; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; IsoId=Q8N8R3-3; Sequence=VSP_055335; Note=No experimental confirmation available.; 
# AltName	MCATL_HUMAN	Carnitine/acylcarnitine translocase-like
# AltName	MCATL_HUMAN	Mitochondrial carnitine/acylcarnitine carrier protein CACL
# AltName	MCATL_HUMAN	Mitochondrial ornithine transporter 3
# AltName	MCATL_HUMAN	Solute carrier family 25 member 29
# CCDS	CCDS32156	-. [Q8N8R3-1]
# DrugBank	DB00583	L-Carnitine
# Ensembl	ENST00000359232	ENSP00000352167; ENSG00000197119. [Q8N8R3-1]
# Ensembl	ENST00000392908	ENSP00000376640; ENSG00000197119. [Q8N8R3-2]
# Ensembl	ENST00000554912	ENSP00000450913; ENSG00000197119. [Q8N8R3-3]
# Ensembl	ENST00000555927	ENSP00000452078; ENSG00000197119. [Q8N8R3-3]
# Ensembl	ENST00000556505	ENSP00000452446; ENSG00000197119. [Q8N8R3-3]
# ExpressionAtlas	Q8N8R3	baseline and differential
# FUNCTION	MCATL_HUMAN	Transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine. Does not transport carnitine nor acylcarnitines. Functions by both counter-exchange and uniport mechanisms. {ECO 0000269|PubMed 19287344, ECO 0000269|PubMed 24652292}. 
# GO_component	GO:0005743	mitochondrial inner membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015227	acyl carnitine transmembrane transporter activity; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# Gene3D	1.50.40.10	-; 1.
# Genevisible	Q8N8R3	HS
# HGNC	HGNC:20116	SLC25A29
# InterPro	IPR002067	Mit_carrier
# InterPro	IPR018108	Mitochondrial_sb/sol_carrier
# InterPro	IPR023395	Mt_carrier_dom
# KEGG_Brite	ko02001	Solute carrier family
# MIM	615064	gene
# Organism	MCATL_HUMAN	Homo sapiens (Human)
# PRINTS	PR00926	MITOCARRIER
# PROSITE	PS50920	SOLCAR; 3
# Pfam	PF00153	Mito_carr; 3
# Proteomes	UP000005640	Chromosome 14
# RecName	MCATL_HUMAN	Mitochondrial basic amino acids transporter
# RefSeq	NP_001034444	NM_001039355.2. [Q8N8R3-1]
# RefSeq	NP_001278742	NM_001291813.1. [Q8N8R3-3]
# RefSeq	NP_001278743	NM_001291814.1. [Q8N8R3-3]
# RefSeq	NP_689546	NM_152333.3. [Q8N8R3-3]
# RefSeq	XP_011534748	XM_011536446.1. [Q8N8R3-3]
# RefSeq	XP_011534749	XM_011536447.1. [Q8N8R3-3]
# RefSeq	XP_011534750	XM_011536448.1. [Q8N8R3-3]
# RefSeq	XP_016876469	XM_017020980.1. [Q8N8R3-3]
# RefSeq	XP_016876470	XM_017020981.1. [Q8N8R3-3]
# RefSeq	XP_016876471	XM_017020982.1. [Q8N8R3-3]
# RefSeq	XP_016876472	XM_017020983.1. [Q8N8R3-3]
# RefSeq	XP_016876473	XM_017020984.1. [Q8N8R3-3]
# RefSeq	XP_016876474	XM_017020985.1. [Q8N8R3-3]
# RefSeq	XP_016876475	XM_017020986.1. [Q8N8R3-3]
# RefSeq	XP_016876476	XM_017020987.1. [Q8N8R3-3]
# SEQUENCE CAUTION	Sequence=CAD62317.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the mitochondrial carrier (TC 2.A.29) family. {ECO	0000305}. 
# SIMILARITY	Contains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule	PRU00282}. 
# SUBCELLULAR LOCATION	MCATL_HUMAN	Mitochondrion inner membrane {ECO 0000269|PubMed 19287344}; Multi-pass membrane protein {ECO 0000269|PubMed 19287344}. 
# SUPFAM	SSF103506	SSF103506
# TCDB	2.A.29.8	the mitochondrial carrier (mc) family
# UCSC	uc001yha	human. [Q8N8R3-1]
# eggNOG	ENOG410XS86	LUCA
# eggNOG	KOG0758	Eukaryota
BLAST	swissprot:MCATL_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MCATL_HUMAN
BioCyc	ZFISH:G66-32232-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32232-MONOMER
COXPRESdb	123096	http://coxpresdb.jp/data/gene/123096.shtml
CleanEx	HS_SLC25A29	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC25A29
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1038/nature01348	http://dx.doi.org/10.1038/nature01348
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M114.547448	http://dx.doi.org/10.1074/jbc.M114.547448
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1203/PDR.0b013e3181a283c1	http://dx.doi.org/10.1203/PDR.0b013e3181a283c1
DrugBank	DB00583	http://www.drugbank.ca/drugs/DB00583
EMBL	AK095532	http://www.ebi.ac.uk/ena/data/view/AK095532
EMBL	AK096294	http://www.ebi.ac.uk/ena/data/view/AK096294
EMBL	AK123821	http://www.ebi.ac.uk/ena/data/view/AK123821
EMBL	AK172788	http://www.ebi.ac.uk/ena/data/view/AK172788
EMBL	AK289627	http://www.ebi.ac.uk/ena/data/view/AK289627
EMBL	AL157871	http://www.ebi.ac.uk/ena/data/view/AL157871
EMBL	BC132964	http://www.ebi.ac.uk/ena/data/view/BC132964
EMBL	BC132966	http://www.ebi.ac.uk/ena/data/view/BC132966
EMBL	BX247983	http://www.ebi.ac.uk/ena/data/view/BX247983
EMBL	CH471061	http://www.ebi.ac.uk/ena/data/view/CH471061
EMBL	CH471061	http://www.ebi.ac.uk/ena/data/view/CH471061
Ensembl	ENST00000359232	http://www.ensembl.org/id/ENST00000359232
Ensembl	ENST00000392908	http://www.ensembl.org/id/ENST00000392908
Ensembl	ENST00000554912	http://www.ensembl.org/id/ENST00000554912
Ensembl	ENST00000555927	http://www.ensembl.org/id/ENST00000555927
Ensembl	ENST00000556505	http://www.ensembl.org/id/ENST00000556505
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015227	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015227
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
Gene3D	1.50.40.10	http://www.cathdb.info/version/latest/superfamily/1.50.40.10
GeneCards	SLC25A29	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC25A29
GeneID	123096	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=123096
GeneTree	ENSGT00700000104295	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00700000104295
HGNC	HGNC:20116	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20116
HOGENOM	HOG000168307	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000168307&db=HOGENOM6
HOVERGEN	HBG003500	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003500&db=HOVERGEN
HPA	HPA030781	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA030781
InParanoid	Q8N8R3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8N8R3
InterPro	IPR002067	http://www.ebi.ac.uk/interpro/entry/IPR002067
InterPro	IPR018108	http://www.ebi.ac.uk/interpro/entry/IPR018108
InterPro	IPR023395	http://www.ebi.ac.uk/interpro/entry/IPR023395
Jabion	123096	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=123096
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:123096	http://www.genome.jp/dbget-bin/www_bget?hsa:123096
KEGG_Orthology	KO:K15109	http://www.genome.jp/dbget-bin/www_bget?KO:K15109
MIM	615064	http://www.ncbi.nlm.nih.gov/omim/615064
OMA	ETPSFGF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ETPSFGF
OrthoDB	EOG091G0HVE	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0HVE
PRINTS	PR00926	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00926
PROSITE	PS50920	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50920
PSORT	swissprot:MCATL_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MCATL_HUMAN
PSORT-B	swissprot:MCATL_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MCATL_HUMAN
PSORT2	swissprot:MCATL_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MCATL_HUMAN
Pfam	PF00153	http://pfam.xfam.org/family/PF00153
PharmGKB	PA134980581	http://www.pharmgkb.org/do/serve?objId=PA134980581&objCls=Gene
Phobius	swissprot:MCATL_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MCATL_HUMAN
PhylomeDB	Q8N8R3	http://phylomedb.org/?seqid=Q8N8R3
ProteinModelPortal	Q8N8R3	http://www.proteinmodelportal.org/query/uniprot/Q8N8R3
PubMed	12508121	http://www.ncbi.nlm.nih.gov/pubmed/12508121
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19287344	http://www.ncbi.nlm.nih.gov/pubmed/19287344
PubMed	24652292	http://www.ncbi.nlm.nih.gov/pubmed/24652292
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
RefSeq	NP_001034444	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001034444
RefSeq	NP_001278742	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001278742
RefSeq	NP_001278743	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001278743
RefSeq	NP_689546	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_689546
RefSeq	XP_011534748	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011534748
RefSeq	XP_011534749	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011534749
RefSeq	XP_011534750	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011534750
RefSeq	XP_016876469	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016876469
RefSeq	XP_016876470	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016876470
RefSeq	XP_016876471	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016876471
RefSeq	XP_016876472	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016876472
RefSeq	XP_016876473	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016876473
RefSeq	XP_016876474	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016876474
RefSeq	XP_016876475	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016876475
RefSeq	XP_016876476	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016876476
STRING	9606.ENSP00000352167	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000352167&targetmode=cogs
SUPFAM	SSF103506	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103506
TCDB	2.A.29.8	http://www.tcdb.org/search/result.php?tc=2.A.29.8
UCSC	uc001yha	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001yha&org=rat
UniGene	Hs.578109	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.578109
UniProtKB	MCATL_HUMAN	http://www.uniprot.org/uniprot/MCATL_HUMAN
UniProtKB-AC	Q8N8R3	http://www.uniprot.org/uniprot/Q8N8R3
charge	swissprot:MCATL_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MCATL_HUMAN
eggNOG	ENOG410XS86	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS86
eggNOG	KOG0758	http://eggnogapi.embl.de/nog_data/html/tree/KOG0758
epestfind	swissprot:MCATL_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MCATL_HUMAN
garnier	swissprot:MCATL_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MCATL_HUMAN
helixturnhelix	swissprot:MCATL_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MCATL_HUMAN
hmoment	swissprot:MCATL_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MCATL_HUMAN
iep	swissprot:MCATL_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MCATL_HUMAN
inforesidue	swissprot:MCATL_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MCATL_HUMAN
neXtProt	NX_Q8N8R3	http://www.nextprot.org/db/entry/NX_Q8N8R3
octanol	swissprot:MCATL_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MCATL_HUMAN
pepcoil	swissprot:MCATL_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MCATL_HUMAN
pepdigest	swissprot:MCATL_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MCATL_HUMAN
pepinfo	swissprot:MCATL_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MCATL_HUMAN
pepnet	swissprot:MCATL_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MCATL_HUMAN
pepstats	swissprot:MCATL_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MCATL_HUMAN
pepwheel	swissprot:MCATL_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MCATL_HUMAN
pepwindow	swissprot:MCATL_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MCATL_HUMAN
sigcleave	swissprot:MCATL_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MCATL_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNS2_HUMAN	Delayed-rectifier K(+) channel alpha subunit 2
# AltName	KCNS2_HUMAN	Voltage-gated potassium channel subunit Kv9.2
# DOMAIN	KCNS2_HUMAN	The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. {ECO 0000250|UniProtKB P63142}. 
# Ensembl	ENST00000287042	ENSP00000287042; ENSG00000156486
# Ensembl	ENST00000521839	ENSP00000430712; ENSG00000156486
# FUNCTION	KCNS2_HUMAN	Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage- gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. {ECO 0000250|UniProtKB O35174}. 
# GO_component	GO:0005886	plasma membrane; ISS:UniProtKB.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IEA:Ensembl.
# GO_component	GO:0016021	integral component of membrane; IBA:GO_Central.
# GO_component	GO:0048471	perinuclear region of cytoplasm; ISS:UniProtKB.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; IBA:GO_Central.
# GO_process	GO:0006813	potassium ion transport; ISS:UniProtKB.
# GO_process	GO:0051260	protein homooligomerization; IEA:InterPro.
# GO_process	GO:1902259	regulation of delayed rectifier potassium channel activity; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.20.120.350	-; 1.
# Genevisible	Q9ULS6	HS
# HGNC	HGNC:6301	KCNS2
# INTERACTION	KCNS2_HUMAN	Q969F0 FATE1; NbExp=5; IntAct=EBI-10323864, EBI-743099; 
# IntAct	Q9ULS6	3
# InterPro	IPR000210	BTB/POZ_dom
# InterPro	IPR003131	T1-type_BTB
# InterPro	IPR003968	K_chnl_volt-dep_Kv
# InterPro	IPR003971	K_chnl_volt-dep_Kv9
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR011333	SKP1/BTB/POZ
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko04040	Ion channels
# MIM	602906	gene
# Organism	KCNS2_HUMAN	Homo sapiens (Human)
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01491	KVCHANNEL
# PRINTS	PR01494	KV9CHANNEL
# Pfam	PF00520	Ion_trans
# Pfam	PF02214	BTB_2
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# RecName	KCNS2_HUMAN	Potassium voltage-gated channel subfamily S member 2
# RefSeq	NP_065748	NM_020697.3
# SEQUENCE CAUTION	Sequence=BAA86458.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.2/KCNS2 sub-subfamily. {ECO	0000305}. 
# SMART	SM00225	BTB
# SUBCELLULAR LOCATION	KCNS2_HUMAN	Cell membrane {ECO 0000250|UniProtKB O35174}; Multi-pass membrane protein {ECO 0000250|UniProtKB O35174}. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 or KCNB2. {ECO 0000250|UniProtKB O35174}. 
# SUBUNIT	Heterotetramer with KCNB1 and KCNB2. Does not form homomultimers. {ECO:0000250|UniProtKB	O35174}. 
# SUPFAM	SSF54695	SSF54695
# TCDB	1.A.1.2.16	the voltage-gated ion channel (vic) superfamily
# UCSC	uc003yin	human
# eggNOG	COG1226	LUCA
# eggNOG	KOG3713	Eukaryota
BLAST	swissprot:KCNS2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNS2_HUMAN
BioCyc	ZFISH:ENSG00000156486-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000156486-MONOMER
COXPRESdb	3788	http://coxpresdb.jp/data/gene/3788.shtml
CleanEx	HS_KCNS2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNS2
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/dnares/6.5.329	http://dx.doi.org/10.1093/dnares/6.5.329
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB032970	http://www.ebi.ac.uk/ena/data/view/AB032970
EMBL	AK293096	http://www.ebi.ac.uk/ena/data/view/AK293096
EMBL	BC027932	http://www.ebi.ac.uk/ena/data/view/BC027932
EMBL	BC034778	http://www.ebi.ac.uk/ena/data/view/BC034778
EMBL	CH471060	http://www.ebi.ac.uk/ena/data/view/CH471060
Ensembl	ENST00000287042	http://www.ensembl.org/id/ENST00000287042
Ensembl	ENST00000521839	http://www.ensembl.org/id/ENST00000521839
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:1902259	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902259
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	KCNS2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNS2
GeneID	3788	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3788
GeneTree	ENSGT00760000118981	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118981
HGNC	HGNC:6301	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6301
HOGENOM	HOG000231016	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231016&db=HOGENOM6
HOVERGEN	HBG052230	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052230&db=HOVERGEN
HPA	HPA051417	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA051417
InParanoid	Q9ULS6	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9ULS6
IntAct	Q9ULS6	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9ULS6*
InterPro	IPR000210	http://www.ebi.ac.uk/interpro/entry/IPR000210
InterPro	IPR003131	http://www.ebi.ac.uk/interpro/entry/IPR003131
InterPro	IPR003968	http://www.ebi.ac.uk/interpro/entry/IPR003968
InterPro	IPR003971	http://www.ebi.ac.uk/interpro/entry/IPR003971
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR011333	http://www.ebi.ac.uk/interpro/entry/IPR011333
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	3788	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3788
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3788	http://www.genome.jp/dbget-bin/www_bget?hsa:3788
KEGG_Orthology	KO:K04932	http://www.genome.jp/dbget-bin/www_bget?KO:K04932
MIM	602906	http://www.ncbi.nlm.nih.gov/omim/602906
OMA	AQREFYF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AQREFYF
OrthoDB	EOG091G0FP3	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0FP3
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01491	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01491
PRINTS	PR01494	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01494
PSORT	swissprot:KCNS2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNS2_HUMAN
PSORT-B	swissprot:KCNS2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNS2_HUMAN
PSORT2	swissprot:KCNS2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNS2_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF02214	http://pfam.xfam.org/family/PF02214
PharmGKB	PA30079	http://www.pharmgkb.org/do/serve?objId=PA30079&objCls=Gene
Phobius	swissprot:KCNS2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNS2_HUMAN
PhylomeDB	Q9ULS6	http://phylomedb.org/?seqid=Q9ULS6
ProteinModelPortal	Q9ULS6	http://www.proteinmodelportal.org/query/uniprot/Q9ULS6
PubMed	10574461	http://www.ncbi.nlm.nih.gov/pubmed/10574461
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
RefSeq	NP_065748	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_065748
SMART	SM00225	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225
SMR	Q9ULS6	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9ULS6
STRING	9606.ENSP00000287042	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000287042&targetmode=cogs
SUPFAM	SSF54695	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54695
TCDB	1.A.1.2.16	http://www.tcdb.org/search/result.php?tc=1.A.1.2.16
UCSC	uc003yin	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003yin&org=rat
UniGene	Hs.388045	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.388045
UniProtKB	KCNS2_HUMAN	http://www.uniprot.org/uniprot/KCNS2_HUMAN
UniProtKB-AC	Q9ULS6	http://www.uniprot.org/uniprot/Q9ULS6
charge	swissprot:KCNS2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNS2_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG3713	http://eggnogapi.embl.de/nog_data/html/tree/KOG3713
epestfind	swissprot:KCNS2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNS2_HUMAN
garnier	swissprot:KCNS2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNS2_HUMAN
helixturnhelix	swissprot:KCNS2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNS2_HUMAN
hmoment	swissprot:KCNS2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNS2_HUMAN
iep	swissprot:KCNS2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNS2_HUMAN
inforesidue	swissprot:KCNS2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNS2_HUMAN
neXtProt	NX_Q9ULS6	http://www.nextprot.org/db/entry/NX_Q9ULS6
octanol	swissprot:KCNS2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNS2_HUMAN
pepcoil	swissprot:KCNS2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNS2_HUMAN
pepdigest	swissprot:KCNS2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNS2_HUMAN
pepinfo	swissprot:KCNS2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNS2_HUMAN
pepnet	swissprot:KCNS2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNS2_HUMAN
pepstats	swissprot:KCNS2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNS2_HUMAN
pepwheel	swissprot:KCNS2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNS2_HUMAN
pepwindow	swissprot:KCNS2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNS2_HUMAN
sigcleave	swissprot:KCNS2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNS2_HUMAN
## Database	ID	URL or Descriptions
# AltName	CXCL7_HUMAN	C-X-C motif chemokine 7
# AltName	CXCL7_HUMAN	LA-PF4
# AltName	CXCL7_HUMAN	Leukocyte-derived growth factor
# AltName	CXCL7_HUMAN	Low-affinity platelet factor IV
# AltName	CXCL7_HUMAN	Low-affinity platelet factor IV
# AltName	CXCL7_HUMAN	Macrophage-derived growth factor
# AltName	CXCL7_HUMAN	Small-inducible cytokine B7
# AltName	CXCL7_HUMAN	Small-inducible cytokine B7
# BioGrid	111469	15
# CDD	cd00273	Chemokine_CXC
# Ensembl	ENST00000296028	ENSP00000296028; ENSG00000163736
# FUNCTION	CXCL7_HUMAN	LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. {ECO 0000269|PubMed 10877842, ECO 0000269|PubMed 7890771, ECO 0000269|PubMed 8950790, ECO 0000269|PubMed 9794434}. 
# GO_component	GO:0005576	extracellular region; TAS:Reactome.
# GO_component	GO:0005615	extracellular space; IBA:GO_Central.
# GO_component	GO:0031093	platelet alpha granule lumen; TAS:Reactome.
# GO_function	GO:0005355	glucose transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0008009	chemokine activity; IBA:GO_Central.
# GO_function	GO:0045236	CXCR chemokine receptor binding; IBA:GO_Central.
# GO_process	GO:0002523	leukocyte migration involved in inflammatory response; IEA:Ensembl.
# GO_process	GO:0002576	platelet degranulation; TAS:Reactome.
# GO_process	GO:0002690	positive regulation of leukocyte chemotaxis; IBA:GO_Central.
# GO_process	GO:0006954	inflammatory response; IBA:GO_Central.
# GO_process	GO:0006955	immune response; IBA:GO_Central.
# GO_process	GO:0007186	G-protein coupled receptor signaling pathway; IBA:GO_Central.
# GO_process	GO:0015758	glucose transport; TAS:ProtInc.
# GO_process	GO:0030593	neutrophil chemotaxis; IEA:InterPro.
# GO_process	GO:0032496	response to lipopolysaccharide; IBA:GO_Central.
# GO_process	GO:0042127	regulation of cell proliferation; IBA:GO_Central.
# GO_process	GO:0042742	defense response to bacterium; IEA:UniProtKB-KW.
# GO_process	GO:0043312	neutrophil degranulation; IEA:InterPro.
# GO_process	GO:0051781	positive regulation of cell division; IEA:UniProtKB-KW.
# GO_process	GO:0070098	chemokine-mediated signaling pathway; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005576	extracellular region
# GOslim_component	GO:0005615	extracellular space
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0048870	cell motility
# Genevisible	P02775	HS
# HGNC	HGNC:9240	PPBP
# IntAct	P02775	20
# InterPro	IPR001089	Chemokine_CXC
# InterPro	IPR001811	Chemokine_IL8-like_dom
# InterPro	IPR018048	Chemokine_CXC_CS
# InterPro	IPR027223	PPBP
# InterPro	IPR033899	CXC_Chemokine_domain
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04052	 Cytokines
# KEGG_Pathway	ko04060	Cytokine-cytokine receptor interaction
# KEGG_Pathway	ko04062	Chemokine signaling pathway
# MIM	121010	gene
# Organism	CXCL7_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10179	PTHR10179
# PANTHER	PTHR10179:SF52	PTHR10179:SF52
# PDB	1F9P	X-ray; 1.93 A; A=44-128
# PDB	1NAP	X-ray; 1.90 A; A/B/C/D=59-128
# PDB	1TVX	X-ray; 1.75 A; A/B/C/D=54-128
# PIR	A39546	TGHU
# PRINTS	PR00437	SMALLCYTKCXC
# PROSITE	PS00471	SMALL_CYTOKINES_CXC
# PTM	CXCL7_HUMAN	NAP-2(1-66) is produced by proteolytical processing, probably after secretion by leukocytes other than neutrophils. {ECO 0000269|PubMed 9794434}. 
# PTM	CXCL7_HUMAN	NAP-2(73) and NAP-2(74) seem not be produced by proteolytical processing of secreted precursors but are released in an active form from platelets. {ECO 0000269|PubMed 9794434}. 
# PTM	CXCL7_HUMAN	Proteolytic removal of residues 1-13 produces the active peptide beta-thromboglobulin, which is released from platelets along with platelet factor 4 and platelet-derived growth factor. 
# PTM	CXCL7_HUMAN	Proteolytic removal of residues 1-9 produces the active peptide connective tissue-activating peptide III (CTAP-III) (low- affinity platelet factor IV (LA-PF4)). 
# Pfam	PF00048	IL8
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-114608	Platelet degranulation
# Reactome	R-HSA-380108	Chemokine receptors bind chemokines
# Reactome	R-HSA-418594	G alpha (i) signalling events
# Reactome	R-HSA-6798695	Neutrophil degranulation
# RecName	CXCL7_HUMAN	Beta-thromboglobulin
# RecName	CXCL7_HUMAN	Connective tissue-activating peptide III
# RecName	CXCL7_HUMAN	Connective tissue-activating peptide III(1-81)
# RecName	CXCL7_HUMAN	Neutrophil-activating peptide 2
# RecName	CXCL7_HUMAN	Neutrophil-activating peptide 2(1-63)
# RecName	CXCL7_HUMAN	Neutrophil-activating peptide 2(1-66)
# RecName	CXCL7_HUMAN	Neutrophil-activating peptide 2(73)
# RecName	CXCL7_HUMAN	Neutrophil-activating peptide 2(74)
# RecName	CXCL7_HUMAN	Platelet basic protein
# RecName	CXCL7_HUMAN	TC-1
# RecName	CXCL7_HUMAN	TC-1
# RecName	CXCL7_HUMAN	TC-2
# RecName	CXCL7_HUMAN	TC-2
# RefSeq	NP_002695	NM_002704.3
# SIMILARITY	Belongs to the intercrine alpha (chemokine CxC) family. {ECO	0000305}. 
# SMART	SM00199	SCY
# SUBCELLULAR LOCATION	CXCL7_HUMAN	Secreted. 
# SUBUNIT	CXCL7_HUMAN	Beta-thromboglobulin is a homotetramer. 
# SUPFAM	SSF54117	SSF54117
# UCSC	uc003hhj	human
# WEB RESOURCE	CXCL7_HUMAN	Name=Wikipedia; Note=CXCL7 entry; URL="https //en.wikipedia.org/wiki/CXCL7";
# eggNOG	ENOG410JG75	Eukaryota
# eggNOG	ENOG4111BTH	LUCA
BLAST	swissprot:CXCL7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CXCL7_HUMAN
BioCyc	ZFISH:ENSG00000163736-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000163736-MONOMER
COXPRESdb	5473	http://coxpresdb.jp/data/gene/5473.shtml
CleanEx	HS_PPBP	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_PPBP
DIP	DIP-5913N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-5913N
DOI	10.1016/0006-291X(89)92203-1	http://dx.doi.org/10.1016/0006-291X(89)92203-1
DOI	10.1016/0006-291X(89)92330-9	http://dx.doi.org/10.1016/0006-291X(89)92330-9
DOI	10.1016/0014-5793(94)00573-7	http://dx.doi.org/10.1016/0014-5793(94)00573-7
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/bi00226a021	http://dx.doi.org/10.1021/bi00226a021
DOI	10.1021/bi00356a023	http://dx.doi.org/10.1021/bi00356a023
DOI	10.1021/bi00602a024	http://dx.doi.org/10.1021/bi00602a024
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/nbt810	http://dx.doi.org/10.1038/nbt810
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.80.3.765	http://dx.doi.org/10.1073/pnas.80.3.765
DOI	10.1074/jbc.270.11.6338	http://dx.doi.org/10.1074/jbc.270.11.6338
DOI	10.1074/jbc.270.13.7077	http://dx.doi.org/10.1074/jbc.270.13.7077
DOI	10.1074/jbc.275.27.20374	http://dx.doi.org/10.1074/jbc.275.27.20374
DOI	10.1084/jem.171.2.449	http://dx.doi.org/10.1084/jem.171.2.449
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1110/ps.04682504	http://dx.doi.org/10.1110/ps.04682504
DOI	10.1182/blood.V98.3.610	http://dx.doi.org/10.1182/blood.V98.3.610
EMBL	AC097709	http://www.ebi.ac.uk/ena/data/view/AC097709
EMBL	AF349466	http://www.ebi.ac.uk/ena/data/view/AF349466
EMBL	AK312166	http://www.ebi.ac.uk/ena/data/view/AK312166
EMBL	BC028217	http://www.ebi.ac.uk/ena/data/view/BC028217
EMBL	CH471057	http://www.ebi.ac.uk/ena/data/view/CH471057
EMBL	CR456805	http://www.ebi.ac.uk/ena/data/view/CR456805
EMBL	M54995	http://www.ebi.ac.uk/ena/data/view/M54995
Ensembl	ENST00000296028	http://www.ensembl.org/id/ENST00000296028
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005576	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576
GO_component	GO:0005615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005615
GO_component	GO:0031093	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031093
GO_function	GO:0005355	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005355
GO_function	GO:0008009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008009
GO_function	GO:0045236	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045236
GO_process	GO:0002523	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002523
GO_process	GO:0002576	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002576
GO_process	GO:0002690	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002690
GO_process	GO:0006954	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006954
GO_process	GO:0006955	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006955
GO_process	GO:0007186	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007186
GO_process	GO:0015758	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015758
GO_process	GO:0030593	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030593
GO_process	GO:0032496	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032496
GO_process	GO:0042127	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042127
GO_process	GO:0042742	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042742
GO_process	GO:0043312	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043312
GO_process	GO:0051781	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051781
GO_process	GO:0070098	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070098
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005576	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576
GOslim_component	GO:0005615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005615
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GeneCards	PPBP	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=PPBP
GeneID	5473	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5473
GeneTree	ENSGT00530000062901	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062901
H-InvDB	HIX0031528	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0031528
HGNC	HGNC:9240	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:9240
HOGENOM	HOG000220915	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220915&db=HOGENOM6
HOVERGEN	HBG107789	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG107789&db=HOVERGEN
HPA	CAB017624	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB017624
HPA	HPA008354	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA008354
InParanoid	P02775	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P02775
IntAct	P02775	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P02775*
InterPro	IPR001089	http://www.ebi.ac.uk/interpro/entry/IPR001089
InterPro	IPR001811	http://www.ebi.ac.uk/interpro/entry/IPR001811
InterPro	IPR018048	http://www.ebi.ac.uk/interpro/entry/IPR018048
InterPro	IPR027223	http://www.ebi.ac.uk/interpro/entry/IPR027223
InterPro	IPR033899	http://www.ebi.ac.uk/interpro/entry/IPR033899
Jabion	5473	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=5473
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04052	http://www.genome.jp/dbget-bin/www_bget?ko04052
KEGG_Gene	hsa:5473	http://www.genome.jp/dbget-bin/www_bget?hsa:5473
KEGG_Orthology	KO:K10029	http://www.genome.jp/dbget-bin/www_bget?KO:K10029
KEGG_Pathway	ko04060	http://www.genome.jp/kegg-bin/show_pathway?ko04060
KEGG_Pathway	ko04062	http://www.genome.jp/kegg-bin/show_pathway?ko04062
MIM	121010	http://www.ncbi.nlm.nih.gov/omim/121010
MINT	MINT-1393871	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1393871
OMA	LYAELRC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LYAELRC
OrthoDB	EOG091G10E9	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G10E9
PANTHER	PTHR10179	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10179
PANTHER	PTHR10179:SF52	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10179:SF52
PDB	1F9P	http://www.ebi.ac.uk/pdbe-srv/view/entry/1F9P
PDB	1NAP	http://www.ebi.ac.uk/pdbe-srv/view/entry/1NAP
PDB	1TVX	http://www.ebi.ac.uk/pdbe-srv/view/entry/1TVX
PDBsum	1F9P	http://www.ebi.ac.uk/pdbsum/1F9P
PDBsum	1NAP	http://www.ebi.ac.uk/pdbsum/1NAP
PDBsum	1TVX	http://www.ebi.ac.uk/pdbsum/1TVX
PRINTS	PR00437	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00437
PROSITE	PS00471	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00471
PSORT	swissprot:CXCL7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CXCL7_HUMAN
PSORT-B	swissprot:CXCL7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CXCL7_HUMAN
PSORT2	swissprot:CXCL7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CXCL7_HUMAN
Pfam	PF00048	http://pfam.xfam.org/family/PF00048
PharmGKB	PA33561	http://www.pharmgkb.org/do/serve?objId=PA33561&objCls=Gene
Phobius	swissprot:CXCL7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CXCL7_HUMAN
PhylomeDB	P02775	http://phylomedb.org/?seqid=P02775
ProteinModelPortal	P02775	http://www.proteinmodelportal.org/query/uniprot/P02775
PubMed	10877842	http://www.ncbi.nlm.nih.gov/pubmed/10877842
PubMed	11468158	http://www.ncbi.nlm.nih.gov/pubmed/11468158
PubMed	12665801	http://www.ncbi.nlm.nih.gov/pubmed/12665801
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15340161	http://www.ncbi.nlm.nih.gov/pubmed/15340161
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	1826003	http://www.ncbi.nlm.nih.gov/pubmed/1826003
PubMed	2007144	http://www.ncbi.nlm.nih.gov/pubmed/2007144
PubMed	2406364	http://www.ncbi.nlm.nih.gov/pubmed/2406364
PubMed	2423119	http://www.ncbi.nlm.nih.gov/pubmed/2423119
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	2522778	http://www.ncbi.nlm.nih.gov/pubmed/2522778
PubMed	2713489	http://www.ncbi.nlm.nih.gov/pubmed/2713489
PubMed	2783111	http://www.ncbi.nlm.nih.gov/pubmed/2783111
PubMed	6572368	http://www.ncbi.nlm.nih.gov/pubmed/6572368
PubMed	7706245	http://www.ncbi.nlm.nih.gov/pubmed/7706245
PubMed	77677	http://www.ncbi.nlm.nih.gov/pubmed/77677
PubMed	7890771	http://www.ncbi.nlm.nih.gov/pubmed/7890771
PubMed	8034022	http://www.ncbi.nlm.nih.gov/pubmed/8034022
PubMed	8950790	http://www.ncbi.nlm.nih.gov/pubmed/8950790
PubMed	9794434	http://www.ncbi.nlm.nih.gov/pubmed/9794434
Reactome	R-HSA-114608	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-114608
Reactome	R-HSA-380108	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-380108
Reactome	R-HSA-418594	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418594
Reactome	R-HSA-6798695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6798695
RefSeq	NP_002695	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002695
SMART	SM00199	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00199
SMR	P02775	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P02775
STRING	9606.ENSP00000296028	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000296028&targetmode=cogs
SUPFAM	SSF54117	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54117
SWISS-2DPAGE	P02775	http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P02775
UCSC	uc003hhj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003hhj&org=rat
UniGene	Hs.2164	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.2164
UniProtKB	CXCL7_HUMAN	http://www.uniprot.org/uniprot/CXCL7_HUMAN
UniProtKB-AC	P02775	http://www.uniprot.org/uniprot/P02775
charge	swissprot:CXCL7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CXCL7_HUMAN
eggNOG	ENOG410JG75	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410JG75
eggNOG	ENOG4111BTH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111BTH
epestfind	swissprot:CXCL7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CXCL7_HUMAN
garnier	swissprot:CXCL7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CXCL7_HUMAN
helixturnhelix	swissprot:CXCL7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CXCL7_HUMAN
hmoment	swissprot:CXCL7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CXCL7_HUMAN
iep	swissprot:CXCL7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CXCL7_HUMAN
inforesidue	swissprot:CXCL7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CXCL7_HUMAN
neXtProt	NX_P02775	http://www.nextprot.org/db/entry/NX_P02775
octanol	swissprot:CXCL7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CXCL7_HUMAN
pepcoil	swissprot:CXCL7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CXCL7_HUMAN
pepdigest	swissprot:CXCL7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CXCL7_HUMAN
pepinfo	swissprot:CXCL7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CXCL7_HUMAN
pepnet	swissprot:CXCL7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CXCL7_HUMAN
pepstats	swissprot:CXCL7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CXCL7_HUMAN
pepwheel	swissprot:CXCL7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CXCL7_HUMAN
pepwindow	swissprot:CXCL7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CXCL7_HUMAN
sigcleave	swissprot:CXCL7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CXCL7_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S39AB_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N1S5-1; Sequence=Displayed; Name=2; IsoId=Q8N1S5-2; Sequence=VSP_028976; 
# AltName	S39AB_HUMAN	Solute carrier family 39 member 11
# AltName	S39AB_HUMAN	Zrt- and Irt-like protein 11
# BioGrid	128379	27
# CCDS	CCDS11690	-. [Q8N1S5-2]
# CCDS	CCDS54160	-. [Q8N1S5-1]
# ChiTaRS	SLC39A11	human
# Ensembl	ENST00000255559	ENSP00000255559; ENSG00000133195. [Q8N1S5-2]
# Ensembl	ENST00000542342	ENSP00000445829; ENSG00000133195. [Q8N1S5-1]
# ExpressionAtlas	Q8N1S5	baseline and differential
# FUNCTION	S39AB_HUMAN	Functions as a cellular zinc transporter. {ECO 0000250|UniProtKB Q8BWY7}. 
# GO_component	GO:0005634	nucleus; ISS:UniProtKB.
# GO_component	GO:0005737	cytoplasm; ISS:UniProtKB.
# GO_component	GO:0005794	Golgi apparatus; ISS:UniProtKB.
# GO_component	GO:0005886	plasma membrane; ISS:UniProtKB.
# GO_component	GO:0016020	membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005385	zinc ion transmembrane transporter activity; ISS:UniProtKB.
# GO_process	GO:0071577	zinc II ion transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q8N1S5	HS
# HGNC	HGNC:14463	SLC39A11
# InterPro	IPR003689	ZIP
# KEGG_Brite	ko02001	Solute carrier family
# MIM	616508	gene
# Organism	S39AB_HUMAN	Homo sapiens (Human)
# Pfam	PF02535	Zip
# Proteomes	UP000005640	Chromosome 17
# RecName	S39AB_HUMAN	Zinc transporter ZIP11
# RefSeq	NP_001153242	NM_001159770.1. [Q8N1S5-1]
# RefSeq	NP_631916	NM_139177.3. [Q8N1S5-2]
# RefSeq	XP_005257191	XM_005257134.3. [Q8N1S5-2]
# RefSeq	XP_006721817	XM_006721754.3. [Q8N1S5-1]
# RefSeq	XP_006721818	XM_006721755.2. [Q8N1S5-1]
# RefSeq	XP_011522795	XM_011524493.1. [Q8N1S5-1]
# RefSeq	XP_011522796	XM_011524494.2. [Q8N1S5-1]
# RefSeq	XP_016879819	XM_017024330.1. [Q8N1S5-2]
# RefSeq	XP_016879820	XM_017024331.1. [Q8N1S5-2]
# RefSeq	XP_016879821	XM_017024332.1. [Q8N1S5-2]
# SIMILARITY	Belongs to the ZIP transporter (TC 2.A.5) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S39AB_HUMAN	Cell membrane {ECO 0000250|UniProtKB Q8BWY7}; Multi-pass membrane protein {ECO 0000250|UniProtKB Q8BWY7}. Nucleus {ECO 0000250|UniProtKB Q8BWY7}. Cytoplasm {ECO 0000250|UniProtKB Q8BWY7}. Golgi apparatus {ECO 0000250|UniProtKB Q8BWY7}. 
# TCDB	2.A.5.5	the zinc (zn(2+))-iron (fe(2+)) permease (zip) family
# UCSC	uc002jja	human. [Q8N1S5-1]
# eggNOG	COG0428	LUCA
# eggNOG	KOG2474	Eukaryota
BLAST	swissprot:S39AB_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S39AB_HUMAN
COXPRESdb	201266	http://coxpresdb.jp/data/gene/201266.shtml
CleanEx	HS_SLC39A11	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC39A11
DOI	10.1006/geno.2001.6648	http://dx.doi.org/10.1006/geno.2001.6648
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC011120	http://www.ebi.ac.uk/ena/data/view/AC011120
EMBL	AC025198	http://www.ebi.ac.uk/ena/data/view/AC025198
EMBL	AC080037	http://www.ebi.ac.uk/ena/data/view/AC080037
EMBL	AC138336	http://www.ebi.ac.uk/ena/data/view/AC138336
EMBL	AF331643	http://www.ebi.ac.uk/ena/data/view/AF331643
EMBL	AK095227	http://www.ebi.ac.uk/ena/data/view/AK095227
EMBL	AK313376	http://www.ebi.ac.uk/ena/data/view/AK313376
EMBL	BC035631	http://www.ebi.ac.uk/ena/data/view/BC035631
EMBL	CH471099	http://www.ebi.ac.uk/ena/data/view/CH471099
Ensembl	ENST00000255559	http://www.ensembl.org/id/ENST00000255559
Ensembl	ENST00000542342	http://www.ensembl.org/id/ENST00000542342
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005385
GO_process	GO:0071577	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071577
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	GC17M072645	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GC17M072645
GeneID	201266	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=201266
GeneTree	ENSGT00390000006167	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000006167
H-InvDB	HIX0014131	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0014131
HGNC	HGNC:14463	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14463
HOGENOM	HOG000232703	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000232703&db=HOGENOM6
HOVERGEN	HBG108448	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108448&db=HOVERGEN
InParanoid	Q8N1S5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8N1S5
InterPro	IPR003689	http://www.ebi.ac.uk/interpro/entry/IPR003689
Jabion	201266	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=201266
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:201266	http://www.genome.jp/dbget-bin/www_bget?hsa:201266
KEGG_Orthology	KO:K14717	http://www.genome.jp/dbget-bin/www_bget?KO:K14717
MIM	616508	http://www.ncbi.nlm.nih.gov/omim/616508
OMA	MIFVVIE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MIFVVIE
OrthoDB	EOG091G0LUY	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0LUY
PSORT	swissprot:S39AB_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S39AB_HUMAN
PSORT-B	swissprot:S39AB_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S39AB_HUMAN
PSORT2	swissprot:S39AB_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S39AB_HUMAN
Pfam	PF02535	http://pfam.xfam.org/family/PF02535
PharmGKB	PA25581	http://www.pharmgkb.org/do/serve?objId=PA25581&objCls=Gene
Phobius	swissprot:S39AB_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S39AB_HUMAN
PhylomeDB	Q8N1S5	http://phylomedb.org/?seqid=Q8N1S5
ProteinModelPortal	Q8N1S5	http://www.proteinmodelportal.org/query/uniprot/Q8N1S5
PubMed	11707075	http://www.ncbi.nlm.nih.gov/pubmed/11707075
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
RefSeq	NP_001153242	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001153242
RefSeq	NP_631916	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_631916
RefSeq	XP_005257191	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005257191
RefSeq	XP_006721817	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006721817
RefSeq	XP_006721818	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006721818
RefSeq	XP_011522795	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011522795
RefSeq	XP_011522796	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011522796
RefSeq	XP_016879819	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016879819
RefSeq	XP_016879820	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016879820
RefSeq	XP_016879821	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016879821
STRING	9606.ENSP00000445829	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000445829&targetmode=cogs
TCDB	2.A.5.5	http://www.tcdb.org/search/result.php?tc=2.A.5.5
UCSC	uc002jja	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002jja&org=rat
UniGene	Hs.221127	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.221127
UniProtKB	S39AB_HUMAN	http://www.uniprot.org/uniprot/S39AB_HUMAN
UniProtKB-AC	Q8N1S5	http://www.uniprot.org/uniprot/Q8N1S5
charge	swissprot:S39AB_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S39AB_HUMAN
eggNOG	COG0428	http://eggnogapi.embl.de/nog_data/html/tree/COG0428
eggNOG	KOG2474	http://eggnogapi.embl.de/nog_data/html/tree/KOG2474
epestfind	swissprot:S39AB_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S39AB_HUMAN
garnier	swissprot:S39AB_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S39AB_HUMAN
helixturnhelix	swissprot:S39AB_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S39AB_HUMAN
hmoment	swissprot:S39AB_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S39AB_HUMAN
iep	swissprot:S39AB_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S39AB_HUMAN
inforesidue	swissprot:S39AB_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S39AB_HUMAN
neXtProt	NX_Q8N1S5	http://www.nextprot.org/db/entry/NX_Q8N1S5
octanol	swissprot:S39AB_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S39AB_HUMAN
pepcoil	swissprot:S39AB_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S39AB_HUMAN
pepdigest	swissprot:S39AB_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S39AB_HUMAN
pepinfo	swissprot:S39AB_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S39AB_HUMAN
pepnet	swissprot:S39AB_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S39AB_HUMAN
pepstats	swissprot:S39AB_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S39AB_HUMAN
pepwheel	swissprot:S39AB_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S39AB_HUMAN
pepwindow	swissprot:S39AB_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S39AB_HUMAN
sigcleave	swissprot:S39AB_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S39AB_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	MPCP_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=A; IsoId=Q00325-1; Sequence=Displayed; Name=B; IsoId=Q00325-2; Sequence=VSP_003269; 
# AltName	MPCP_HUMAN	Phosphate transport protein
# AltName	MPCP_HUMAN	Solute carrier family 25 member 3
# BioGrid	111269	132
# CCDS	CCDS9065	-. [Q00325-2]
# CCDS	CCDS9066	-. [Q00325-1]
# ChiTaRS	SLC25A3	human
# DISEASE	MPCP_HUMAN	Mitochondrial phosphate carrier deficiency (MPCD) [MIM 610773]  Fatal disorder of oxidative phosphorylation. Patients have lactic acidosis, hypertrophic cardiomyopathy and muscular hypotonia and die within the first year of life. {ECO 0000269|PubMed 17273968}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000188376	ENSP00000188376; ENSG00000075415. [Q00325-2]
# Ensembl	ENST00000228318	ENSP00000228318; ENSG00000075415. [Q00325-1]
# Ensembl	ENST00000401722	ENSP00000383898; ENSG00000075415. [Q00325-2]
# Ensembl	ENST00000549338	ENSP00000447740; ENSG00000075415. [Q00325-2]
# Ensembl	ENST00000551917	ENSP00000447310; ENSG00000075415. [Q00325-1]
# Ensembl	ENST00000552981	ENSP00000448708; ENSG00000075415. [Q00325-2]
# ExpressionAtlas	Q00325	baseline and differential
# FUNCTION	MPCP_HUMAN	Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP). 
# GO_component	GO:0005634	nucleus; IDA:HPA.
# GO_component	GO:0005730	nucleolus; IDA:HPA.
# GO_component	GO:0005739	mitochondrion; IDA:HPA.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:ProtInc.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0043209	myelin sheath; IEA:Ensembl.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_function	GO:0015320	phosphate ion carrier activity; TAS:ProtInc.
# GO_function	GO:0032403	protein complex binding; IDA:MGI.
# GO_process	GO:0006091	generation of precursor metabolites and energy; TAS:ProtInc.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005730	nucleolus
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# GOslim_process	GO:0006810	transport
# Gene3D	1.50.40.10	-; 1.
# Genevisible	Q00325	HS
# HGNC	HGNC:10989	SLC25A3
# IntAct	Q00325	41
# InterPro	IPR018108	Mitochondrial_sb/sol_carrier
# InterPro	IPR023395	Mt_carrier_dom
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H01348	[Inherited metabolic disease; Mitochondrial disease] Mitochondrial phosphate carrier deficiency (MPCD)
# MIM	600370	gene
# MIM	610773	phenotype
# Organism	MPCP_HUMAN	Homo sapiens (Human)
# Orphanet	91130	Cardiomyopathy - hypotonia - lactic acidosis
# PIR	A53737	A53737
# PIR	B53737	B53737
# PROSITE	PS50920	SOLCAR; 3
# Pfam	PF00153	Mito_carr; 3
# Proteomes	UP000005640	Chromosome 12
# RecName	MPCP_HUMAN	Phosphate carrier protein, mitochondrial
# RefSeq	NP_002626	NM_002635.3. [Q00325-2]
# RefSeq	NP_005879	NM_005888.3. [Q00325-1]
# RefSeq	NP_998776	NM_213611.2. [Q00325-2]
# SIMILARITY	Belongs to the mitochondrial carrier (TC 2.A.29) family. {ECO	0000305}. 
# SIMILARITY	Contains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule	PRU00282}.
# SUBCELLULAR LOCATION	MPCP_HUMAN	Mitochondrion inner membrane; Multi-pass membrane protein. 
# SUBUNIT	Interacts with PPIF; the interaction is impaired by CsA. {ECO	0000250}. 
# SUPFAM	SSF103506	SSF103506
# TCDB	2.A.29.4	the mitochondrial carrier (mc) family
# TopDownProteomics	Q00325-1	-. [Q00325-1]
# TopDownProteomics	Q00325-2	-. [Q00325-2]
# UCSC	uc001tfm	human. [Q00325-1]
# eggNOG	ENOG410XPST	LUCA
# eggNOG	KOG0767	Eukaryota
BLAST	swissprot:MPCP_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MPCP_HUMAN
BioCyc	ZFISH:ENSG00000075415-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000075415-MONOMER
COXPRESdb	5250	http://coxpresdb.jp/data/gene/5250.shtml
CleanEx	HS_SLC25A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC25A3
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/mcp.M800588-MCP200	http://dx.doi.org/10.1074/mcp.M800588-MCP200
DOI	10.1074/mcp.O113.027870	http://dx.doi.org/10.1074/mcp.O113.027870
DOI	10.1086/511788	http://dx.doi.org/10.1086/511788
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AB064666	http://www.ebi.ac.uk/ena/data/view/AB064666
EMBL	AK092689	http://www.ebi.ac.uk/ena/data/view/AK092689
EMBL	BC000998	http://www.ebi.ac.uk/ena/data/view/BC000998
EMBL	BC001328	http://www.ebi.ac.uk/ena/data/view/BC001328
EMBL	BC003504	http://www.ebi.ac.uk/ena/data/view/BC003504
EMBL	BC004345	http://www.ebi.ac.uk/ena/data/view/BC004345
EMBL	BC006455	http://www.ebi.ac.uk/ena/data/view/BC006455
EMBL	BC011574	http://www.ebi.ac.uk/ena/data/view/BC011574
EMBL	BC011641	http://www.ebi.ac.uk/ena/data/view/BC011641
EMBL	BC014019	http://www.ebi.ac.uk/ena/data/view/BC014019
EMBL	BC015379	http://www.ebi.ac.uk/ena/data/view/BC015379
EMBL	BC051367	http://www.ebi.ac.uk/ena/data/view/BC051367
EMBL	CH471054	http://www.ebi.ac.uk/ena/data/view/CH471054
EMBL	CH471054	http://www.ebi.ac.uk/ena/data/view/CH471054
EMBL	X60036	http://www.ebi.ac.uk/ena/data/view/X60036
EMBL	X77337	http://www.ebi.ac.uk/ena/data/view/X77337
EMBL	X77337	http://www.ebi.ac.uk/ena/data/view/X77337
Ensembl	ENST00000188376	http://www.ensembl.org/id/ENST00000188376
Ensembl	ENST00000228318	http://www.ensembl.org/id/ENST00000228318
Ensembl	ENST00000401722	http://www.ensembl.org/id/ENST00000401722
Ensembl	ENST00000549338	http://www.ensembl.org/id/ENST00000549338
Ensembl	ENST00000551917	http://www.ensembl.org/id/ENST00000551917
Ensembl	ENST00000552981	http://www.ensembl.org/id/ENST00000552981
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005730
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0043209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043209
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_function	GO:0015320	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015320
GO_function	GO:0032403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032403
GO_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005730
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
Gene3D	1.50.40.10	http://www.cathdb.info/version/latest/superfamily/1.50.40.10
GeneCards	SLC25A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC25A3
GeneID	5250	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5250
GeneTree	ENSGT00390000008708	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000008708
HGNC	HGNC:10989	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10989
HOGENOM	HOG000164438	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000164438&db=HOGENOM6
HOVERGEN	HBG024440	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG024440&db=HOVERGEN
HPA	HPA045709	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA045709
InParanoid	Q00325	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q00325
IntAct	Q00325	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q00325*
InterPro	IPR018108	http://www.ebi.ac.uk/interpro/entry/IPR018108
InterPro	IPR023395	http://www.ebi.ac.uk/interpro/entry/IPR023395
Jabion	5250	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=5250
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H01348	http://www.genome.jp/dbget-bin/www_bget?H01348
KEGG_Gene	hsa:5250	http://www.genome.jp/dbget-bin/www_bget?hsa:5250
KEGG_Orthology	KO:K15102	http://www.genome.jp/dbget-bin/www_bget?KO:K15102
MIM	600370	http://www.ncbi.nlm.nih.gov/omim/600370
MIM	610773	http://www.ncbi.nlm.nih.gov/omim/610773
MINT	MINT-1156379	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1156379
OMA	LKFYALC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LKFYALC
Orphanet	91130	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=91130
OrthoDB	EOG091G0FJF	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0FJF
PROSITE	PS50920	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50920
PSORT	swissprot:MPCP_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MPCP_HUMAN
PSORT-B	swissprot:MPCP_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MPCP_HUMAN
PSORT2	swissprot:MPCP_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MPCP_HUMAN
Pfam	PF00153	http://pfam.xfam.org/family/PF00153
PharmGKB	PA35865	http://www.pharmgkb.org/do/serve?objId=PA35865&objCls=Gene
Phobius	swissprot:MPCP_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MPCP_HUMAN
PhylomeDB	Q00325	http://phylomedb.org/?seqid=Q00325
ProteinModelPortal	Q00325	http://www.proteinmodelportal.org/query/uniprot/Q00325
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17273968	http://www.ncbi.nlm.nih.gov/pubmed/17273968
PubMed	1777677	http://www.ncbi.nlm.nih.gov/pubmed/1777677
PubMed	19369195	http://www.ncbi.nlm.nih.gov/pubmed/19369195
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	24129315	http://www.ncbi.nlm.nih.gov/pubmed/24129315
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	8144629	http://www.ncbi.nlm.nih.gov/pubmed/8144629
RefSeq	NP_002626	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002626
RefSeq	NP_005879	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005879
RefSeq	NP_998776	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_998776
STRING	9606.ENSP00000228318	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000228318&targetmode=cogs
SUPFAM	SSF103506	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103506
TCDB	2.A.29.4	http://www.tcdb.org/search/result.php?tc=2.A.29.4
UCSC	uc001tfm	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001tfm&org=rat
UniGene	Hs.290404	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.290404
UniProtKB	MPCP_HUMAN	http://www.uniprot.org/uniprot/MPCP_HUMAN
UniProtKB-AC	Q00325	http://www.uniprot.org/uniprot/Q00325
charge	swissprot:MPCP_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MPCP_HUMAN
eggNOG	ENOG410XPST	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPST
eggNOG	KOG0767	http://eggnogapi.embl.de/nog_data/html/tree/KOG0767
epestfind	swissprot:MPCP_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MPCP_HUMAN
garnier	swissprot:MPCP_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MPCP_HUMAN
helixturnhelix	swissprot:MPCP_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MPCP_HUMAN
hmoment	swissprot:MPCP_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MPCP_HUMAN
iep	swissprot:MPCP_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MPCP_HUMAN
inforesidue	swissprot:MPCP_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MPCP_HUMAN
neXtProt	NX_Q00325	http://www.nextprot.org/db/entry/NX_Q00325
octanol	swissprot:MPCP_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MPCP_HUMAN
pepcoil	swissprot:MPCP_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MPCP_HUMAN
pepdigest	swissprot:MPCP_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MPCP_HUMAN
pepinfo	swissprot:MPCP_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MPCP_HUMAN
pepnet	swissprot:MPCP_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MPCP_HUMAN
pepstats	swissprot:MPCP_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MPCP_HUMAN
pepwheel	swissprot:MPCP_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MPCP_HUMAN
pepwindow	swissprot:MPCP_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MPCP_HUMAN
sigcleave	swissprot:MPCP_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MPCP_HUMAN
## Database	ID	URL or Descriptions
# AltName	PEX3_HUMAN	Peroxin-3
# AltName	PEX3_HUMAN	Peroxisomal assembly protein PEX3
# BioGrid	114076	8
# DISEASE	PEX3_HUMAN	Peroxisome biogenesis disorder 10A (PBD10A) [MIM 614882]  A fatal peroxisome biogenesis disorder belonging to the Zellweger disease spectrum and clinically characterized by severe neurologic dysfunction with profound psychomotor retardation, severe hypotonia and neonatal seizures, craniofacial abnormalities, liver dysfunction, and biochemically by the absence of peroxisomes. Additional features include cardiovascular and skeletal defects, renal cysts, ocular abnormalities, and hearing impairment. Most severely affected individuals with the classic form of the disease (classic Zellweger syndrome) die within the first year of life. {ECO 0000269|PubMed 10848631, ECO 0000269|PubMed 10958759}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	PEX3_HUMAN	Peroxisome biogenesis disorder complementation group 12 (PBD-CG12) [MIM 614882]  A peroxisomal disorder arising from a failure of protein import into the peroxisomal membrane or matrix. The peroxisome biogenesis disorders (PBD group) are genetically heterogeneous with at least 14 distinct genetic groups as concluded from complementation studies. Include disorders are  Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). ZWS, NALD and IRD are distinct from RCDP and constitute a clinical continuum of overlapping phenotypes known as the Zellweger spectrum (PBD-ZSS). {ECO 0000269|PubMed 10958759}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000367591	ENSP00000356563; ENSG00000034693
# ExpressionAtlas	P56589	baseline and differential
# FUNCTION	PEX3_HUMAN	Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes. {ECO 0000269|PubMed 10848631, ECO 0000269|PubMed 15007061}. 
# GO_component	GO:0005654	nucleoplasm; IDA:HPA.
# GO_component	GO:0005777	peroxisome; IMP:UniProtKB.
# GO_component	GO:0005778	peroxisomal membrane; IDA:UniProtKB.
# GO_component	GO:0005779	integral component of peroxisomal membrane; IDA:UniProtKB.
# GO_component	GO:0005783	endoplasmic reticulum; IDA:UniProtKB.
# GO_component	GO:0005829	cytosol; IEA:Ensembl.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0032994	protein-lipid complex; IDA:UniProtKB.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_component	GO:0043234	protein complex; IDA:UniProtKB.
# GO_function	GO:0008289	lipid binding; IDA:UniProtKB.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0046983	protein dimerization activity; IDA:UniProtKB.
# GO_process	GO:0003333	amino acid transmembrane transport; IBA:GO_Central.
# GO_process	GO:0007031	peroxisome organization; IMP:UniProtKB.
# GO_process	GO:0016557	peroxisome membrane biogenesis; IEA:Ensembl.
# GO_process	GO:0045046	protein import into peroxisome membrane; IMP:UniProtKB.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005777	peroxisome
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008289	lipid binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006605	protein targeting
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# GOslim_process	GO:0061024	membrane organization
# Genevisible	P56589	HS
# HGNC	HGNC:8858	PEX3
# INTERACTION	PEX3_HUMAN	P40855 PEX19; NbExp=27; IntAct=EBI-594885, EBI-594747; 
# IntAct	P56589	4
# InterPro	IPR006966	Peroxin-3
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Disease	H00205:[Inherited metabolic disease; Nervous system disease; Liver disease; Peroxisomal disease] Rhizomelic chondrodysplasia punctata (RCDP1) [DS	H00207]
# KEGG_Disease	H01342	[Inherited metabolic disease; Nervous system disease; Liver disease; Peroxisomal disease] Zellweger syndrome (ZS)
# KEGG_Pathway	ko04146	Peroxisome
# MIM	603164	gene
# MIM	614882	phenotype
# Organism	PEX3_HUMAN	Homo sapiens (Human)
# Orphanet	44	Neonatal adrenoleukodystrophy
# Orphanet	772	Infantile Refsum disease
# Orphanet	912	Zellweger syndrome
# PDB	3AJB	X-ray; 2.50 A; A=49-373
# PDB	3MK4	X-ray; 2.42 A; A=41-373
# Pfam	PF04882	Peroxin-3; 2
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-1369062	ABC transporters in lipid homeostasis
# RecName	PEX3_HUMAN	Peroxisomal biogenesis factor 3
# RefSeq	NP_003621	NM_003630.2
# SIMILARITY	Belongs to the peroxin-3 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	PEX3_HUMAN	Peroxisome membrane {ECO 0000269|PubMed 11390669}; Multi-pass membrane protein {ECO 0000269|PubMed 11390669}. 
# SUBUNIT	PEX3_HUMAN	Interacts with PEX19. {ECO 0000269|PubMed 10704444, ECO 0000269|PubMed 11390669, ECO 0000269|PubMed 20554521, ECO 0000269|PubMed 21102411}. 
# TCDB	9.A.17.1	the integral membrane peroxisomal protein importer-2 (ppi2) family
# TISSUE SPECIFICITY	PEX3_HUMAN	Found in all examined tissues. 
# UCSC	uc003qjl	human
# eggNOG	ENOG41101IY	LUCA
# eggNOG	KOG4444	Eukaryota
BLAST	swissprot:PEX3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:PEX3_HUMAN
BioCyc	ZFISH:ENSG00000034693-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000034693-MONOMER
COXPRESdb	8504	http://coxpresdb.jp/data/gene/8504.shtml
CleanEx	HS_PEX3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_PEX3
DOI	10.1006/bbrc.2000.2193	http://dx.doi.org/10.1006/bbrc.2000.2193
DOI	10.1016/S0014-5793(98)00557-2	http://dx.doi.org/10.1016/S0014-5793(98)00557-2
DOI	10.1038/emboj.2010.293	http://dx.doi.org/10.1038/emboj.2010.293
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1074/jbc.M110.138503	http://dx.doi.org/10.1074/jbc.M110.138503
DOI	10.1083/jcb.148.5.931	http://dx.doi.org/10.1083/jcb.148.5.931
DOI	10.1083/jcb.200311131	http://dx.doi.org/10.1083/jcb.200311131
DOI	10.1086/303071	http://dx.doi.org/10.1086/303071
DOI	10.1091/mbc.11.6.2085	http://dx.doi.org/10.1091/mbc.11.6.2085
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1128/MCB.21.13.4413-4424.2001	http://dx.doi.org/10.1128/MCB.21.13.4413-4424.2001
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AB035307	http://www.ebi.ac.uk/ena/data/view/AB035307
EMBL	AJ001625	http://www.ebi.ac.uk/ena/data/view/AJ001625
EMBL	AJ009866	http://www.ebi.ac.uk/ena/data/view/AJ009866
EMBL	AJ009867	http://www.ebi.ac.uk/ena/data/view/AJ009867
EMBL	AJ009868	http://www.ebi.ac.uk/ena/data/view/AJ009868
EMBL	AJ009869	http://www.ebi.ac.uk/ena/data/view/AJ009869
EMBL	AJ009870	http://www.ebi.ac.uk/ena/data/view/AJ009870
EMBL	AJ009871	http://www.ebi.ac.uk/ena/data/view/AJ009871
EMBL	AJ009872	http://www.ebi.ac.uk/ena/data/view/AJ009872
EMBL	AJ009873	http://www.ebi.ac.uk/ena/data/view/AJ009873
EMBL	AJ009874	http://www.ebi.ac.uk/ena/data/view/AJ009874
EMBL	AJ131389	http://www.ebi.ac.uk/ena/data/view/AJ131389
EMBL	AL031320	http://www.ebi.ac.uk/ena/data/view/AL031320
EMBL	AY277600	http://www.ebi.ac.uk/ena/data/view/AY277600
EMBL	BC014551	http://www.ebi.ac.uk/ena/data/view/BC014551
EMBL	BC015506	http://www.ebi.ac.uk/ena/data/view/BC015506
EMBL	CH471051	http://www.ebi.ac.uk/ena/data/view/CH471051
EMBL	CR542062	http://www.ebi.ac.uk/ena/data/view/CR542062
Ensembl	ENST00000367591	http://www.ensembl.org/id/ENST00000367591
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005777	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005777
GO_component	GO:0005778	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005778
GO_component	GO:0005779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005779
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0032994	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032994
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GO_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_function	GO:0046983	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046983
GO_process	GO:0003333	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003333
GO_process	GO:0007031	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007031
GO_process	GO:0016557	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016557
GO_process	GO:0045046	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045046
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005777	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005777
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
GeneCards	PEX3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=PEX3
GeneID	8504	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8504
GeneTree	ENSGT00390000008481	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000008481
HGNC	HGNC:8858	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:8858
HOGENOM	HOG000007212	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007212&db=HOGENOM6
HOVERGEN	HBG000467	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000467&db=HOVERGEN
HPA	HPA042830	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042830
HPA	HPA058006	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA058006
InParanoid	P56589	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P56589
IntAct	P56589	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P56589*
InterPro	IPR006966	http://www.ebi.ac.uk/interpro/entry/IPR006966
Jabion	8504	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=8504
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Disease	H00205	http://www.genome.jp/dbget-bin/www_bget?H00205
KEGG_Disease	H01342	http://www.genome.jp/dbget-bin/www_bget?H01342
KEGG_Gene	hsa:8504	http://www.genome.jp/dbget-bin/www_bget?hsa:8504
KEGG_Orthology	KO:K13336	http://www.genome.jp/dbget-bin/www_bget?KO:K13336
KEGG_Pathway	ko04146	http://www.genome.jp/kegg-bin/show_pathway?ko04146
MIM	603164	http://www.ncbi.nlm.nih.gov/omim/603164
MIM	614882	http://www.ncbi.nlm.nih.gov/omim/614882
MINT	MINT-241504	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-241504
OMA	ARRQFHF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ARRQFHF
Orphanet	44	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=44
Orphanet	772	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=772
Orphanet	912	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=912
OrthoDB	EOG091G1027	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G1027
PDB	3AJB	http://www.ebi.ac.uk/pdbe-srv/view/entry/3AJB
PDB	3MK4	http://www.ebi.ac.uk/pdbe-srv/view/entry/3MK4
PDBsum	3AJB	http://www.ebi.ac.uk/pdbsum/3AJB
PDBsum	3MK4	http://www.ebi.ac.uk/pdbsum/3MK4
PSORT	swissprot:PEX3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:PEX3_HUMAN
PSORT-B	swissprot:PEX3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:PEX3_HUMAN
PSORT2	swissprot:PEX3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:PEX3_HUMAN
Pfam	PF04882	http://pfam.xfam.org/family/PF04882
PharmGKB	PA33200	http://www.pharmgkb.org/do/serve?objId=PA33200&objCls=Gene
Phobius	swissprot:PEX3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:PEX3_HUMAN
PhylomeDB	P56589	http://phylomedb.org/?seqid=P56589
ProteinModelPortal	P56589	http://www.proteinmodelportal.org/query/uniprot/P56589
PubMed	10430017	http://www.ncbi.nlm.nih.gov/pubmed/10430017
PubMed	10679269	http://www.ncbi.nlm.nih.gov/pubmed/10679269
PubMed	10704444	http://www.ncbi.nlm.nih.gov/pubmed/10704444
PubMed	10848631	http://www.ncbi.nlm.nih.gov/pubmed/10848631
PubMed	10958759	http://www.ncbi.nlm.nih.gov/pubmed/10958759
PubMed	11390669	http://www.ncbi.nlm.nih.gov/pubmed/11390669
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	15007061	http://www.ncbi.nlm.nih.gov/pubmed/15007061
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	20554521	http://www.ncbi.nlm.nih.gov/pubmed/20554521
PubMed	21102411	http://www.ncbi.nlm.nih.gov/pubmed/21102411
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	9657383	http://www.ncbi.nlm.nih.gov/pubmed/9657383
Reactome	R-HSA-1369062	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1369062
RefSeq	NP_003621	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003621
SMR	P56589	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P56589
STRING	9606.ENSP00000356563	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000356563&targetmode=cogs
TCDB	9.A.17.1	http://www.tcdb.org/search/result.php?tc=9.A.17.1
UCSC	uc003qjl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003qjl&org=rat
UniGene	Hs.592832	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.592832
UniGene	Hs.7277	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.7277
UniProtKB	PEX3_HUMAN	http://www.uniprot.org/uniprot/PEX3_HUMAN
UniProtKB-AC	P56589	http://www.uniprot.org/uniprot/P56589
charge	swissprot:PEX3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:PEX3_HUMAN
eggNOG	ENOG41101IY	http://eggnogapi.embl.de/nog_data/html/tree/ENOG41101IY
eggNOG	KOG4444	http://eggnogapi.embl.de/nog_data/html/tree/KOG4444
epestfind	swissprot:PEX3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:PEX3_HUMAN
garnier	swissprot:PEX3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:PEX3_HUMAN
helixturnhelix	swissprot:PEX3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:PEX3_HUMAN
hmoment	swissprot:PEX3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:PEX3_HUMAN
iep	swissprot:PEX3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:PEX3_HUMAN
inforesidue	swissprot:PEX3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:PEX3_HUMAN
neXtProt	NX_P56589	http://www.nextprot.org/db/entry/NX_P56589
octanol	swissprot:PEX3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:PEX3_HUMAN
pepcoil	swissprot:PEX3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:PEX3_HUMAN
pepdigest	swissprot:PEX3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:PEX3_HUMAN
pepinfo	swissprot:PEX3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:PEX3_HUMAN
pepnet	swissprot:PEX3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:PEX3_HUMAN
pepstats	swissprot:PEX3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:PEX3_HUMAN
pepwheel	swissprot:PEX3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:PEX3_HUMAN
pepwindow	swissprot:PEX3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:PEX3_HUMAN
sigcleave	swissprot:PEX3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:PEX3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	COG3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96JB2-1; Sequence=Displayed; Name=2; IsoId=Q96JB2-2; Sequence=VSP_013652, VSP_013653; Note=No experimental confirmation available.; 
# AltName	COG3_HUMAN	Component of oligomeric Golgi complex 3
# AltName	COG3_HUMAN	Vesicle-docking protein SEC34 homolog
# AltName	COG3_HUMAN	p94
# BioGrid	123680	37
# CCDS	CCDS9398	-. [Q96JB2-1]
# ChiTaRS	COG3	human
# Ensembl	ENST00000349995	ENSP00000258654; ENSG00000136152. [Q96JB2-1]
# Ensembl	ENST00000617493	ENSP00000481332; ENSG00000136152. [Q96JB2-2]
# ExpressionAtlas	Q96JB2	baseline and differential
# FUNCTION	COG3_HUMAN	Involved in ER-Golgi transport. {ECO 0000269|PubMed 11929878}. 
# GO_component	GO:0000139	Golgi membrane; TAS:Reactome.
# GO_component	GO:0005654	nucleoplasm; IDA:HPA.
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0005794	Golgi apparatus; IDA:UniProtKB.
# GO_component	GO:0005801	cis-Golgi network; IEA:InterPro.
# GO_component	GO:0005886	plasma membrane; IDA:HPA.
# GO_component	GO:0017119	Golgi transport complex; IDA:UniProtKB.
# GO_component	GO:0032580	Golgi cisterna membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0032588	trans-Golgi network membrane; TAS:Reactome.
# GO_function	GO:0008565	protein transporter activity; IDA:UniProtKB.
# GO_process	GO:0000301	retrograde transport, vesicle recycling within Golgi; IBA:GO_Central.
# GO_process	GO:0006486	protein glycosylation; IMP:UniProtKB.
# GO_process	GO:0006886	intracellular protein transport; IEA:InterPro.
# GO_process	GO:0006888	ER to Golgi vesicle-mediated transport; IDA:UniProtKB.
# GO_process	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER; IMP:UniProtKB.
# GO_process	GO:0006891	intra-Golgi vesicle-mediated transport; IDA:UniProtKB.
# GO_process	GO:0007030	Golgi organization; IMP:UniProtKB.
# GO_process	GO:0033365	protein localization to organelle; IMP:UniProtKB.
# GO_process	GO:0050821	protein stabilization; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# Genevisible	Q96JB2	HS
# HGNC	HGNC:18619	COG3
# IntAct	Q96JB2	12
# InterPro	IPR007265	COG_su3
# MIM	606975	gene
# Organism	COG3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR13302	PTHR13302
# Pfam	PF04136	Sec34
# Proteomes	UP000005640	Chromosome 13
# Reactome	R-HSA-6807878	COPI-mediated anterograde transport
# Reactome	R-HSA-6811438	Intra-Golgi traffic
# Reactome	R-HSA-6811440	Retrograde transport at the Trans-Golgi-Network
# RecName	COG3_HUMAN	Conserved oligomeric Golgi complex subunit 3
# RefSeq	NP_113619	NM_031431.3
# SIMILARITY	Belongs to the COG3 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	COG3_HUMAN	Golgi apparatus, Golgi stack membrane {ECO 0000269|PubMed 11292827}; Peripheral membrane protein {ECO 0000269|PubMed 11292827}. Note=Associated with the peripheral membrane of cis/medial cisternae. 
# SUBUNIT	Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Interacts with TMEM115. {ECO:0000250, ECO	0000269|PubMed:24806965}. 
# TISSUE SPECIFICITY	Widely expressed with highest levels in pancreas and testis and lowest levels in lung. {ECO:0000269|PubMed	11292827}. 
# UCSC	uc001vai	human. [Q96JB2-1]
# eggNOG	ENOG410XNXH	LUCA
# eggNOG	KOG2604	Eukaryota
BLAST	swissprot:COG3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:COG3_HUMAN
BioCyc	ZFISH:ENSG00000136152-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000136152-MONOMER
COXPRESdb	83548	http://coxpresdb.jp/data/gene/83548.shtml
CleanEx	HS_COG3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_COG3
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature02379	http://dx.doi.org/10.1038/nature02379
DOI	10.1038/nbt810	http://dx.doi.org/10.1038/nbt810
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1074/jbc.M011624200	http://dx.doi.org/10.1074/jbc.M011624200
DOI	10.1074/jbc.M202326200	http://dx.doi.org/10.1074/jbc.M202326200
DOI	10.1074/mcp.M111.015131	http://dx.doi.org/10.1074/mcp.M111.015131
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1242/jcs.136754	http://dx.doi.org/10.1242/jcs.136754
EMBL	AF332595	http://www.ebi.ac.uk/ena/data/view/AF332595
EMBL	AF349676	http://www.ebi.ac.uk/ena/data/view/AF349676
EMBL	AK314387	http://www.ebi.ac.uk/ena/data/view/AK314387
EMBL	AL139326	http://www.ebi.ac.uk/ena/data/view/AL139326
EMBL	AL606514	http://www.ebi.ac.uk/ena/data/view/AL606514
EMBL	BC038953	http://www.ebi.ac.uk/ena/data/view/BC038953
Ensembl	ENST00000349995	http://www.ensembl.org/id/ENST00000349995
Ensembl	ENST00000617493	http://www.ensembl.org/id/ENST00000617493
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005801	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005801
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0017119	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017119
GO_component	GO:0032580	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032580
GO_component	GO:0032588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032588
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0000301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000301
GO_process	GO:0006486	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006486
GO_process	GO:0006886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006886
GO_process	GO:0006888	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006888
GO_process	GO:0006890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006890
GO_process	GO:0006891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006891
GO_process	GO:0007030	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007030
GO_process	GO:0033365	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033365
GO_process	GO:0050821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050821
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GeneCards	COG3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=COG3
GeneID	83548	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83548
GeneTree	ENSGT00390000015682	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000015682
H-InvDB	HIX0011290	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0011290
HGNC	HGNC:18619	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18619
HOGENOM	HOG000264596	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264596&db=HOGENOM6
HOVERGEN	HBG051062	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051062&db=HOVERGEN
HPA	HPA040353	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA040353
InParanoid	Q96JB2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96JB2
IntAct	Q96JB2	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96JB2*
InterPro	IPR007265	http://www.ebi.ac.uk/interpro/entry/IPR007265
Jabion	83548	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=83548
KEGG_Gene	hsa:83548	http://www.genome.jp/dbget-bin/www_bget?hsa:83548
MIM	606975	http://www.ncbi.nlm.nih.gov/omim/606975
MINT	MINT-3054332	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3054332
OMA	KIPEYQQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KIPEYQQ
OrthoDB	EOG091G03O0	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G03O0
PANTHER	PTHR13302	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13302
PSORT	swissprot:COG3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:COG3_HUMAN
PSORT-B	swissprot:COG3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:COG3_HUMAN
PSORT2	swissprot:COG3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:COG3_HUMAN
Pfam	PF04136	http://pfam.xfam.org/family/PF04136
PharmGKB	PA38602	http://www.pharmgkb.org/do/serve?objId=PA38602&objCls=Gene
Phobius	swissprot:COG3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:COG3_HUMAN
PhylomeDB	Q96JB2	http://phylomedb.org/?seqid=Q96JB2
ProteinModelPortal	Q96JB2	http://www.proteinmodelportal.org/query/uniprot/Q96JB2
PubMed	11292827	http://www.ncbi.nlm.nih.gov/pubmed/11292827
PubMed	11929878	http://www.ncbi.nlm.nih.gov/pubmed/11929878
PubMed	12665801	http://www.ncbi.nlm.nih.gov/pubmed/12665801
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15057823	http://www.ncbi.nlm.nih.gov/pubmed/15057823
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22223895	http://www.ncbi.nlm.nih.gov/pubmed/22223895
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24806965	http://www.ncbi.nlm.nih.gov/pubmed/24806965
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-6807878	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6807878
Reactome	R-HSA-6811438	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6811438
Reactome	R-HSA-6811440	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6811440
RefSeq	NP_113619	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_113619
SMR	Q96JB2	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q96JB2
STRING	9606.ENSP00000258654	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000258654&targetmode=cogs
UCSC	uc001vai	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001vai&org=rat
UniGene	Hs.507948	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.507948
UniProtKB	COG3_HUMAN	http://www.uniprot.org/uniprot/COG3_HUMAN
UniProtKB-AC	Q96JB2	http://www.uniprot.org/uniprot/Q96JB2
charge	swissprot:COG3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:COG3_HUMAN
eggNOG	ENOG410XNXH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNXH
eggNOG	KOG2604	http://eggnogapi.embl.de/nog_data/html/tree/KOG2604
epestfind	swissprot:COG3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:COG3_HUMAN
garnier	swissprot:COG3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:COG3_HUMAN
helixturnhelix	swissprot:COG3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:COG3_HUMAN
hmoment	swissprot:COG3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:COG3_HUMAN
iep	swissprot:COG3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:COG3_HUMAN
inforesidue	swissprot:COG3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:COG3_HUMAN
neXtProt	NX_Q96JB2	http://www.nextprot.org/db/entry/NX_Q96JB2
octanol	swissprot:COG3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:COG3_HUMAN
pepcoil	swissprot:COG3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:COG3_HUMAN
pepdigest	swissprot:COG3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:COG3_HUMAN
pepinfo	swissprot:COG3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:COG3_HUMAN
pepnet	swissprot:COG3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:COG3_HUMAN
pepstats	swissprot:COG3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:COG3_HUMAN
pepwheel	swissprot:COG3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:COG3_HUMAN
pepwindow	swissprot:COG3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:COG3_HUMAN
sigcleave	swissprot:COG3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:COG3_HUMAN
## Database	ID	URL or Descriptions
# AltName	COX7B_HUMAN	Cytochrome c oxidase polypeptide VIIb
# CDD	cd01403	Cyt_c_Oxidase_VIIb
# ChiTaRS	COX7B	human
# DISEASE	COX7B_HUMAN	Linear skin defects with multiple congenital anomalies 2 (LSDMCA2) [MIM 300887]  A distinct form of aplasia cutis congenita presenting as multiple linear skin defects on the face and neck associated with poor growth, microcephaly, and facial dysmorphism. Additional features include intellectual disability, nail dystrophy, short stature and cardiac abnormalities. {ECO 0000269|PubMed 23122588}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB02659	Cholic Acid
# Ensembl	ENST00000481445	ENSP00000417656; ENSG00000131174
# FUNCTION	COX7B_HUMAN	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Plays a role in proper central nervous system (CNS) development in vertebrates. {ECO 0000269|PubMed 23122588}. 
# GO_component	GO:0005739	mitochondrion; IBA:GO_Central.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0005746	mitochondrial respiratory chain; IEA:InterPro.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0045277	respiratory chain complex IV; IBA:GO_Central.
# GO_function	GO:0004129	cytochrome-c oxidase activity; TAS:ProtInc.
# GO_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen; TAS:Reactome.
# GO_process	GO:0007417	central nervous system development; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# GOslim_process	GO:0048856	anatomical structure development
# Gene3D	4.10.51.10	-; 1.
# Genevisible	P24311	HS
# HGNC	HGNC:2291	COX7B
# IntAct	P24311	2
# InterPro	IPR008433	Cyt_c_oxidase_suVIIB
# InterPro	IPR023272	Cyt_c_oxidase_suVIIB_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	300885	gene
# MIM	300887	phenotype
# Organism	COX7B_HUMAN	Homo sapiens (Human)
# Orphanet	2556	Microphthalmia with linear skin defects syndrome
# PANTHER	PTHR16716	PTHR16716
# PIR	S29856	OSHU7B
# Pfam	PF05392	COX7B
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-5628897	TP53 Regulates Metabolic Genes
# Reactome	R-HSA-611105	Respiratory electron transport
# RecName	COX7B_HUMAN	Cytochrome c oxidase subunit 7B, mitochondrial
# RefSeq	NP_001857	NM_001866.2
# SIMILARITY	Belongs to the cytochrome c oxidase VIIb family. {ECO	0000305}.
# SUBCELLULAR LOCATION	COX7B_HUMAN	Mitochondrion inner membrane {ECO 0000250}. 
# SUPFAM	SSF81423	SSF81423
# UCSC	uc004ecu	human
# eggNOG	ENOG410J3GK	Eukaryota
# eggNOG	ENOG4112BN9	LUCA
BLAST	swissprot:COX7B_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:COX7B_HUMAN
BioCyc	ZFISH:HS05498-MONOMER	http://biocyc.org/getid?id=ZFISH:HS05498-MONOMER
COXPRESdb	1349	http://coxpresdb.jp/data/gene/1349.shtml
CleanEx	HS_COX7B	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_COX7B
DOI	10.1016/0167-4781(93)90301-S	http://dx.doi.org/10.1016/0167-4781(93)90301-S
DOI	10.1016/j.ajhg.2012.09.016	http://dx.doi.org/10.1016/j.ajhg.2012.09.016
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1432-1033.1992.tb19847.x	http://dx.doi.org/10.1111/j.1432-1033.1992.tb19847.x
DrugBank	DB02659	http://www.drugbank.ca/drugs/DB02659
EMBL	AK311879	http://www.ebi.ac.uk/ena/data/view/AK311879
EMBL	AL356235	http://www.ebi.ac.uk/ena/data/view/AL356235
EMBL	BC018386	http://www.ebi.ac.uk/ena/data/view/BC018386
EMBL	BT009767	http://www.ebi.ac.uk/ena/data/view/BT009767
EMBL	CH471104	http://www.ebi.ac.uk/ena/data/view/CH471104
EMBL	CR450332	http://www.ebi.ac.uk/ena/data/view/CR450332
EMBL	CR542124	http://www.ebi.ac.uk/ena/data/view/CR542124
EMBL	Z14244	http://www.ebi.ac.uk/ena/data/view/Z14244
Ensembl	ENST00000481445	http://www.ensembl.org/id/ENST00000481445
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005746	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005746
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0045277	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045277
GO_function	GO:0004129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004129
GO_process	GO:0006123	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006123
GO_process	GO:0007417	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007417
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
Gene3D	4.10.51.10	http://www.cathdb.info/version/latest/superfamily/4.10.51.10
GeneCards	COX7B	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=COX7B
GeneID	1349	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1349
GeneTree	ENSGT00390000012178	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000012178
HGNC	HGNC:2291	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2291
HOGENOM	HOG000059529	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000059529&db=HOGENOM6
HOVERGEN	HBG051092	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051092&db=HOVERGEN
HPA	HPA058041	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA058041
InParanoid	P24311	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24311
IntAct	P24311	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24311*
InterPro	IPR008433	http://www.ebi.ac.uk/interpro/entry/IPR008433
InterPro	IPR023272	http://www.ebi.ac.uk/interpro/entry/IPR023272
Jabion	1349	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1349
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Gene	hsa:1349	http://www.genome.jp/dbget-bin/www_bget?hsa:1349
KEGG_Orthology	KO:K02271	http://www.genome.jp/dbget-bin/www_bget?KO:K02271
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	300885	http://www.ncbi.nlm.nih.gov/omim/300885
MIM	300887	http://www.ncbi.nlm.nih.gov/omim/300887
OMA	AVWAYTA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AVWAYTA
Orphanet	2556	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=2556
OrthoDB	EOG091G1342	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G1342
PANTHER	PTHR16716	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16716
PSORT	swissprot:COX7B_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:COX7B_HUMAN
PSORT-B	swissprot:COX7B_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:COX7B_HUMAN
PSORT2	swissprot:COX7B_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:COX7B_HUMAN
Pfam	PF05392	http://pfam.xfam.org/family/PF05392
PharmGKB	PA26809	http://www.pharmgkb.org/do/serve?objId=PA26809&objCls=Gene
Phobius	swissprot:COX7B_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:COX7B_HUMAN
PhylomeDB	P24311	http://phylomedb.org/?seqid=P24311
ProteinModelPortal	P24311	http://www.proteinmodelportal.org/query/uniprot/P24311
PubMed	1309697	http://www.ncbi.nlm.nih.gov/pubmed/1309697
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	23122588	http://www.ncbi.nlm.nih.gov/pubmed/23122588
PubMed	8382530	http://www.ncbi.nlm.nih.gov/pubmed/8382530
Reactome	R-HSA-5628897	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5628897
Reactome	R-HSA-611105	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-611105
RefSeq	NP_001857	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001857
SMR	P24311	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24311
STRING	9606.ENSP00000417656	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000417656&targetmode=cogs
SUPFAM	SSF81423	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81423
UCSC	uc004ecu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004ecu&org=rat
UniGene	Hs.522699	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.522699
UniProtKB	COX7B_HUMAN	http://www.uniprot.org/uniprot/COX7B_HUMAN
UniProtKB-AC	P24311	http://www.uniprot.org/uniprot/P24311
charge	swissprot:COX7B_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:COX7B_HUMAN
eggNOG	ENOG410J3GK	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410J3GK
eggNOG	ENOG4112BN9	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4112BN9
epestfind	swissprot:COX7B_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:COX7B_HUMAN
garnier	swissprot:COX7B_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:COX7B_HUMAN
helixturnhelix	swissprot:COX7B_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:COX7B_HUMAN
hmoment	swissprot:COX7B_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:COX7B_HUMAN
iep	swissprot:COX7B_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:COX7B_HUMAN
inforesidue	swissprot:COX7B_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:COX7B_HUMAN
neXtProt	NX_P24311	http://www.nextprot.org/db/entry/NX_P24311
octanol	swissprot:COX7B_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:COX7B_HUMAN
pepcoil	swissprot:COX7B_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:COX7B_HUMAN
pepdigest	swissprot:COX7B_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:COX7B_HUMAN
pepinfo	swissprot:COX7B_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:COX7B_HUMAN
pepnet	swissprot:COX7B_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:COX7B_HUMAN
pepstats	swissprot:COX7B_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:COX7B_HUMAN
pepwheel	swissprot:COX7B_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:COX7B_HUMAN
pepwindow	swissprot:COX7B_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:COX7B_HUMAN
sigcleave	swissprot:COX7B_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:COX7B_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SC5A1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P13866-1; Sequence=Displayed; Name=2; IsoId=P13866-2; Sequence=VSP_044782; Note=No experimental confirmation available.; 
# AltName	SC5A1_HUMAN	High affinity sodium-glucose cotransporter
# AltName	SC5A1_HUMAN	Solute carrier family 5 member 1
# BioGrid	112414	2
# CCDS	CCDS13902	-. [P13866-1]
# CCDS	CCDS58805	-. [P13866-2]
# ChiTaRS	SLC5A1	human
# DISEASE	SC5A1_HUMAN	Congenital glucose/galactose malabsorption (GGM) [MIM 606824]  Intestinal monosaccharide transporter deficiency. It is an autosomal recessive disorder manifesting itself within the first weeks of life. It is characterized by severe diarrhea and dehydration which are usually fatal unless glucose and galactose are eliminated from the diet. {ECO 0000269|PubMed 10036327, ECO 0000269|PubMed 11406349, ECO 0000269|PubMed 2008213, ECO 0000269|PubMed 8195156}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB08907	Canagliflozin
# Ensembl	ENST00000266088	ENSP00000266088; ENSG00000100170. [P13866-1]
# Ensembl	ENST00000543737	ENSP00000444898; ENSG00000100170. [P13866-2]
# FUNCTION	SC5A1_HUMAN	Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2 1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0005911	cell-cell junction; IEA:Ensembl.
# GO_component	GO:0016324	apical plasma membrane; IEA:Ensembl.
# GO_component	GO:0031526	brush border membrane; IEA:Ensembl.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	SC5A1_HUMAN	GO 0005412 glucose sodium symporter activity; IDA MGI.
# GO_process	GO:0001951	intestinal D-glucose absorption; IBA:GO_Central.
# GO_process	GO:0008645	hexose transport; TAS:Reactome.
# GO_process	GO:0015758	glucose transport; IMP:MGI.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	P13866	HS
# HGNC	HGNC:11036	SLC5A1
# INTERACTION	SC5A1_HUMAN	P00533 EGFR; NbExp=3; IntAct=EBI-1772443, EBI-297353; 
# InterPro	IPR001734	Na/solute_symporter
# InterPro	IPR018212	Na/solute_symporter_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H01261	[Inherited metabolic disease] Congenital glucose-galactose malabsorption (GGM)
# KEGG_Pathway	ko04973	Carbohydrate digestion and absorption
# KEGG_Pathway	ko04976	Bile secretion
# KEGG_Pathway	ko04978	Mineral absorption
# MIM	182380	gene
# MIM	606824	phenotype
# Organism	SC5A1_HUMAN	Homo sapiens (Human)
# Orphanet	35710	Glucose-galactose malabsorption
# PANTHER	PTHR11819	PTHR11819; 2
# PIR	A33545	A33545
# PROSITE	PS00456	NA_SOLUT_SYMP_1
# PROSITE	PS00457	NA_SOLUT_SYMP_2
# PROSITE	PS50283	NA_SOLUT_SYMP_3
# PTM	SC5A1_HUMAN	N-glycosylation is not necessary for the cotransporter function. {ECO 0000269|PubMed 8567640}. 
# Pfam	PF00474	SSF
# Proteomes	UP000005640	Chromosome 22
# Reactome	R-HSA-189200	Hexose transport
# Reactome	R-HSA-428808	Na+-dependent glucose transporters
# Reactome	R-HSA-429593	Inositol transporters
# RecName	SC5A1_HUMAN	Sodium/glucose cotransporter 1
# RefSeq	NP_000334	NM_000343.3. [P13866-1]
# RefSeq	NP_001243243	NM_001256314.1. [P13866-2]
# SIMILARITY	Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	SC5A1_HUMAN	Membrane; Multi-pass membrane protein. 
# TCDB	2.A.21.3:the solute	sodium symporter (sss) family
# TIGRFAMs	TIGR00813	sss
# TISSUE SPECIFICITY	SC5A1_HUMAN	Expressed mainly in intestine and kidney. 
# UCSC	uc003amc	human. [P13866-1]
# eggNOG	COG4146	LUCA
# eggNOG	ENOG410IP49	Eukaryota
BLAST	swissprot:SC5A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SC5A1_HUMAN
BioCyc	ZFISH:ENSG00000100170-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000100170-MONOMER
COXPRESdb	6523	http://coxpresdb.jp/data/gene/6523.shtml
CleanEx	HS_SLC5A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC5A1
DOI	10.1016/S0925-4439(01)00043-6	http://dx.doi.org/10.1016/S0925-4439(01)00043-6
DOI	10.1016/S0925-4439(98)00109-4	http://dx.doi.org/10.1016/S0925-4439(98)00109-4
DOI	10.1038/350354a0	http://dx.doi.org/10.1038/350354a0
DOI	10.1038/990031	http://dx.doi.org/10.1038/990031
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.86.15.5748	http://dx.doi.org/10.1073/pnas.86.15.5748
DOI	10.1074/jbc.271.4.1925	http://dx.doi.org/10.1074/jbc.271.4.1925
DOI	10.1186/gb-2004-5-10-r84	http://dx.doi.org/10.1186/gb-2004-5-10-r84
DrugBank	DB08907	http://www.drugbank.ca/drugs/DB08907
EMBL	AK297665	http://www.ebi.ac.uk/ena/data/view/AK297665
EMBL	AK312948	http://www.ebi.ac.uk/ena/data/view/AK312948
EMBL	AK316184	http://www.ebi.ac.uk/ena/data/view/AK316184
EMBL	AL022321	http://www.ebi.ac.uk/ena/data/view/AL022321
EMBL	AL022321	http://www.ebi.ac.uk/ena/data/view/AL022321
EMBL	AL022321	http://www.ebi.ac.uk/ena/data/view/AL022321
EMBL	AL022321	http://www.ebi.ac.uk/ena/data/view/AL022321
EMBL	AL022321	http://www.ebi.ac.uk/ena/data/view/AL022321
EMBL	CH471095	http://www.ebi.ac.uk/ena/data/view/CH471095
EMBL	CR456579	http://www.ebi.ac.uk/ena/data/view/CR456579
EMBL	L29328	http://www.ebi.ac.uk/ena/data/view/L29328
EMBL	L29329	http://www.ebi.ac.uk/ena/data/view/L29329
EMBL	L29330	http://www.ebi.ac.uk/ena/data/view/L29330
EMBL	L29331	http://www.ebi.ac.uk/ena/data/view/L29331
EMBL	L29332	http://www.ebi.ac.uk/ena/data/view/L29332
EMBL	L29333	http://www.ebi.ac.uk/ena/data/view/L29333
EMBL	L29334	http://www.ebi.ac.uk/ena/data/view/L29334
EMBL	L29335	http://www.ebi.ac.uk/ena/data/view/L29335
EMBL	L29336	http://www.ebi.ac.uk/ena/data/view/L29336
EMBL	L29337	http://www.ebi.ac.uk/ena/data/view/L29337
EMBL	L29338	http://www.ebi.ac.uk/ena/data/view/L29338
EMBL	L29339	http://www.ebi.ac.uk/ena/data/view/L29339
EMBL	M24847	http://www.ebi.ac.uk/ena/data/view/M24847
EMBL	Z74021	http://www.ebi.ac.uk/ena/data/view/Z74021
EMBL	Z74021	http://www.ebi.ac.uk/ena/data/view/Z74021
EMBL	Z74021	http://www.ebi.ac.uk/ena/data/view/Z74021
EMBL	Z74021	http://www.ebi.ac.uk/ena/data/view/Z74021
EMBL	Z74021	http://www.ebi.ac.uk/ena/data/view/Z74021
EMBL	Z80998	http://www.ebi.ac.uk/ena/data/view/Z80998
EMBL	Z80998	http://www.ebi.ac.uk/ena/data/view/Z80998
EMBL	Z80998	http://www.ebi.ac.uk/ena/data/view/Z80998
EMBL	Z80998	http://www.ebi.ac.uk/ena/data/view/Z80998
EMBL	Z80998	http://www.ebi.ac.uk/ena/data/view/Z80998
EMBL	Z83839	http://www.ebi.ac.uk/ena/data/view/Z83839
EMBL	Z83839	http://www.ebi.ac.uk/ena/data/view/Z83839
EMBL	Z83839	http://www.ebi.ac.uk/ena/data/view/Z83839
EMBL	Z83839	http://www.ebi.ac.uk/ena/data/view/Z83839
EMBL	Z83839	http://www.ebi.ac.uk/ena/data/view/Z83839
EMBL	Z83849	http://www.ebi.ac.uk/ena/data/view/Z83849
EMBL	Z83849	http://www.ebi.ac.uk/ena/data/view/Z83849
EMBL	Z83849	http://www.ebi.ac.uk/ena/data/view/Z83849
EMBL	Z83849	http://www.ebi.ac.uk/ena/data/view/Z83849
EMBL	Z83849	http://www.ebi.ac.uk/ena/data/view/Z83849
Ensembl	ENST00000266088	http://www.ensembl.org/id/ENST00000266088
Ensembl	ENST00000543737	http://www.ensembl.org/id/ENST00000543737
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005911	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005911
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0031526	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031526
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005412	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005412
GO_process	GO:0001951	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001951
GO_process	GO:0008645	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008645
GO_process	GO:0015758	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015758
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC5A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC5A1
GeneID	6523	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6523
GeneTree	ENSGT00760000118955	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118955
HGNC	HGNC:11036	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11036
HOVERGEN	HBG052859	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052859&db=HOVERGEN
HPA	CAB015467	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB015467
HPA	HPA051805	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA051805
HPA	HPA055106	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA055106
InParanoid	P13866	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P13866
IntAct	P13866	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P13866*
InterPro	IPR001734	http://www.ebi.ac.uk/interpro/entry/IPR001734
InterPro	IPR018212	http://www.ebi.ac.uk/interpro/entry/IPR018212
Jabion	6523	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6523
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H01261	http://www.genome.jp/dbget-bin/www_bget?H01261
KEGG_Gene	hsa:6523	http://www.genome.jp/dbget-bin/www_bget?hsa:6523
KEGG_Orthology	KO:K14158	http://www.genome.jp/dbget-bin/www_bget?KO:K14158
KEGG_Pathway	ko04973	http://www.genome.jp/kegg-bin/show_pathway?ko04973
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
KEGG_Pathway	ko04978	http://www.genome.jp/kegg-bin/show_pathway?ko04978
MIM	182380	http://www.ncbi.nlm.nih.gov/omim/182380
MIM	606824	http://www.ncbi.nlm.nih.gov/omim/606824
OMA	KAGCTLC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KAGCTLC
Orphanet	35710	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=35710
OrthoDB	EOG091G077U	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G077U
PANTHER	PTHR11819	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11819
PROSITE	PS00456	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00456
PROSITE	PS00457	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00457
PROSITE	PS50283	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50283
PSORT	swissprot:SC5A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SC5A1_HUMAN
PSORT-B	swissprot:SC5A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SC5A1_HUMAN
PSORT2	swissprot:SC5A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SC5A1_HUMAN
Pfam	PF00474	http://pfam.xfam.org/family/PF00474
PharmGKB	PA308	http://www.pharmgkb.org/do/serve?objId=PA308&objCls=Gene
Phobius	swissprot:SC5A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SC5A1_HUMAN
PhylomeDB	P13866	http://phylomedb.org/?seqid=P13866
ProteinModelPortal	P13866	http://www.proteinmodelportal.org/query/uniprot/P13866
PubMed	10036327	http://www.ncbi.nlm.nih.gov/pubmed/10036327
PubMed	10591208	http://www.ncbi.nlm.nih.gov/pubmed/10591208
PubMed	11406349	http://www.ncbi.nlm.nih.gov/pubmed/11406349
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15461802	http://www.ncbi.nlm.nih.gov/pubmed/15461802
PubMed	2008213	http://www.ncbi.nlm.nih.gov/pubmed/2008213
PubMed	2490366	http://www.ncbi.nlm.nih.gov/pubmed/2490366
PubMed	8195156	http://www.ncbi.nlm.nih.gov/pubmed/8195156
PubMed	8567640	http://www.ncbi.nlm.nih.gov/pubmed/8567640
Reactome	R-HSA-189200	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-189200
Reactome	R-HSA-428808	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428808
Reactome	R-HSA-429593	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-429593
RefSeq	NP_000334	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000334
RefSeq	NP_001243243	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243243
STRING	9606.ENSP00000266088	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000266088&targetmode=cogs
TCDB	2.A.21.3	http://www.tcdb.org/search/result.php?tc=2.A.21.3
TIGRFAMs	TIGR00813	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00813
UCSC	uc003amc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003amc&org=rat
UniGene	Hs.1964	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.1964
UniProtKB	SC5A1_HUMAN	http://www.uniprot.org/uniprot/SC5A1_HUMAN
UniProtKB-AC	P13866	http://www.uniprot.org/uniprot/P13866
charge	swissprot:SC5A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SC5A1_HUMAN
eggNOG	COG4146	http://eggnogapi.embl.de/nog_data/html/tree/COG4146
eggNOG	ENOG410IP49	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IP49
epestfind	swissprot:SC5A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SC5A1_HUMAN
garnier	swissprot:SC5A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SC5A1_HUMAN
helixturnhelix	swissprot:SC5A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SC5A1_HUMAN
hmoment	swissprot:SC5A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SC5A1_HUMAN
iep	swissprot:SC5A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SC5A1_HUMAN
inforesidue	swissprot:SC5A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SC5A1_HUMAN
neXtProt	NX_P13866	http://www.nextprot.org/db/entry/NX_P13866
octanol	swissprot:SC5A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SC5A1_HUMAN
pepcoil	swissprot:SC5A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SC5A1_HUMAN
pepdigest	swissprot:SC5A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SC5A1_HUMAN
pepinfo	swissprot:SC5A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SC5A1_HUMAN
pepnet	swissprot:SC5A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SC5A1_HUMAN
pepstats	swissprot:SC5A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SC5A1_HUMAN
pepwheel	swissprot:SC5A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SC5A1_HUMAN
pepwindow	swissprot:SC5A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SC5A1_HUMAN
sigcleave	swissprot:SC5A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SC5A1_HUMAN
## Database	ID	URL or Descriptions
# AltName	NMD3A_HUMAN	N-methyl-D-aspartate receptor subtype 3A
# AltName	NMD3A_HUMAN	NMDAR-L
# BioGrid	125508	2
# DEVELOPMENTAL STAGE	NMD3A_HUMAN	Expressed in fetal brain. 
# DrugBank	DB00193	Tramadol
# DrugBank	DB00289	Atomoxetine
# DrugBank	DB00312	Pentobarbital
# DrugBank	DB00333	Methadone
# DrugBank	DB00392	Ethopropazine
# DrugBank	DB00418	Secobarbital
# DrugBank	DB00514	Dextromethorphan
# DrugBank	DB00659	Acamprosate
# DrugBank	DB00721	Procaine
# DrugBank	DB00898	Ethanol
# DrugBank	DB00915	Amantadine
# DrugBank	DB00949	Felbamate
# DrugBank	DB00996	Gabapentin
# DrugBank	DB01043	Memantine
# DrugBank	DB01159	Halothane
# DrugBank	DB01161	Chloroprocaine
# DrugBank	DB01173	Orphenadrine
# DrugBank	DB01174	Phenobarbital
# DrugBank	DB01221	Ketamine
# DrugBank	DB04896	Milnacipran
# DrugBank	DB06151	Acetylcysteine
# DrugBank	DB06738	Ketobemidone
# Ensembl	ENST00000361820	ENSP00000355155; ENSG00000198785
# FUNCTION	NMD3A_HUMAN	NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity). {ECO 0000250}. 
# GO_component	GO:0014069	postsynaptic density; IEA:UniProtKB-SubCell.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0017146	NMDA selective glutamate receptor complex; IDA:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0043005	neuron projection; IDA:UniProtKB.
# GO_component	GO:0043025	neuronal cell body; IDA:UniProtKB.
# GO_component	GO:0045202	synapse; IDA:UniProtKB.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0004972	NMDA glutamate receptor activity; IDA:UniProtKB.
# GO_function	GO:0005234	extracellular-glutamate-gated ion channel activity; IEA:InterPro.
# GO_function	GO:0005262	calcium channel activity; IEA:Ensembl.
# GO_function	GO:0016594	glycine binding; IDA:UniProtKB.
# GO_function	GO:0042802	identical protein binding; IPI:UniProtKB.
# GO_function	GO:0051721	protein phosphatase 2A binding; ISS:UniProtKB.
# GO_process	GO:0006816	calcium ion transport; ISS:UniProtKB.
# GO_process	GO:0016358	dendrite development; IEA:Ensembl.
# GO_process	GO:0045471	response to ethanol; IDA:UniProtKB.
# GO_process	GO:0060134	prepulse inhibition; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# Genevisible	Q8TCU5	HS
# HGNC	HGNC:16767	GRIN3A
# InterPro	IPR001320	Iontro_rcpt
# InterPro	IPR001508	Iono_rcpt_met
# InterPro	IPR019594	Glu/Gly-bd
# InterPro	IPR028082	Peripla_BP_I
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04724	Glutamatergic synapse
# KEGG_Pathway	ko05030	Cocaine addiction
# KEGG_Pathway	ko05031	Amphetamine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# KEGG_Pathway	ko05034	Alcoholism
# MIM	606650	gene
# Organism	NMD3A_HUMAN	Homo sapiens (Human)
# PRINTS	PR00177	NMDARECEPTOR
# PTM	NMD3A_HUMAN	N-glycosylated. {ECO 0000250}. 
# Pfam	PF00060	Lig_chan
# Pfam	PF10613	Lig_chan-Glu_bd
# Proteomes	UP000005640	Chromosome 9
# RecName	NMD3A_HUMAN	Glutamate receptor ionotropic, NMDA 3A
# RefSeq	NP_597702	NM_133445.2
# SEQUENCE CAUTION	Sequence=BAB85559.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR3A/GRIN3A subfamily. {ECO	0000305}. 
# SMART	SM00079	PBPe
# SMART	SM00918	Lig_chan-Glu_bd
# SUBCELLULAR LOCATION	NMD3A_HUMAN	Cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO 0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO 0000250}. Note=Enriched in postsynaptic plasma membrane and postsynaptic densities. Requires the presence of GRIN1 to be targeted at the plasma membrane (By similarity). {ECO 0000250}. 
# SUBUNIT	Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex with GRIN1, GRIN2A or GRIN2B and PPP2CB. Probably interacts with PPP2CB. No complex with PPP2CB is detected when NMDARs are stimulated by NMDA (By similarity). {ECO	0000250}. 
# SUPFAM	SSF53822	SSF53822
# UCSC	uc004bbp	human
# eggNOG	ENOG410XNUR	LUCA
# eggNOG	KOG1053	Eukaryota
BLAST	swissprot:NMD3A_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NMD3A_HUMAN
BioCyc	ZFISH:G66-33690-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33690-MONOMER
COXPRESdb	116443	http://coxpresdb.jp/data/gene/116443.shtml
CleanEx	HS_GRIN3A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GRIN3A
DOI	10.1006/geno.2001.6666	http://dx.doi.org/10.1006/geno.2001.6666
DOI	10.1016/S0304-3940(01)02524-1	http://dx.doi.org/10.1016/S0304-3940(01)02524-1
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
DOI	10.1093/dnares/8.6.319	http://dx.doi.org/10.1093/dnares/8.6.319
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1196/annals.1300.049	http://dx.doi.org/10.1196/annals.1300.049
DrugBank	DB00193	http://www.drugbank.ca/drugs/DB00193
DrugBank	DB00289	http://www.drugbank.ca/drugs/DB00289
DrugBank	DB00312	http://www.drugbank.ca/drugs/DB00312
DrugBank	DB00333	http://www.drugbank.ca/drugs/DB00333
DrugBank	DB00392	http://www.drugbank.ca/drugs/DB00392
DrugBank	DB00418	http://www.drugbank.ca/drugs/DB00418
DrugBank	DB00514	http://www.drugbank.ca/drugs/DB00514
DrugBank	DB00659	http://www.drugbank.ca/drugs/DB00659
DrugBank	DB00721	http://www.drugbank.ca/drugs/DB00721
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB00915	http://www.drugbank.ca/drugs/DB00915
DrugBank	DB00949	http://www.drugbank.ca/drugs/DB00949
DrugBank	DB00996	http://www.drugbank.ca/drugs/DB00996
DrugBank	DB01043	http://www.drugbank.ca/drugs/DB01043
DrugBank	DB01159	http://www.drugbank.ca/drugs/DB01159
DrugBank	DB01161	http://www.drugbank.ca/drugs/DB01161
DrugBank	DB01173	http://www.drugbank.ca/drugs/DB01173
DrugBank	DB01174	http://www.drugbank.ca/drugs/DB01174
DrugBank	DB01221	http://www.drugbank.ca/drugs/DB01221
DrugBank	DB04896	http://www.drugbank.ca/drugs/DB04896
DrugBank	DB06151	http://www.drugbank.ca/drugs/DB06151
DrugBank	DB06738	http://www.drugbank.ca/drugs/DB06738
EMBL	AB075853	http://www.ebi.ac.uk/ena/data/view/AB075853
EMBL	AF416558	http://www.ebi.ac.uk/ena/data/view/AF416558
EMBL	AJ416950	http://www.ebi.ac.uk/ena/data/view/AJ416950
EMBL	AL356516	http://www.ebi.ac.uk/ena/data/view/AL356516
EMBL	AL356516	http://www.ebi.ac.uk/ena/data/view/AL356516
EMBL	AL591377	http://www.ebi.ac.uk/ena/data/view/AL591377
EMBL	AL591377	http://www.ebi.ac.uk/ena/data/view/AL591377
EMBL	BC167432	http://www.ebi.ac.uk/ena/data/view/BC167432
Ensembl	ENST00000361820	http://www.ensembl.org/id/ENST00000361820
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0014069	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014069
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0017146	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017146
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0043005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043005
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0045202	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045202
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0004972	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004972
GO_function	GO:0005234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005234
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0016594	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016594
GO_function	GO:0042802	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802
GO_function	GO:0051721	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051721
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0016358	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016358
GO_process	GO:0045471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045471
GO_process	GO:0060134	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060134
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GeneCards	GRIN3A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GRIN3A
GeneID	116443	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=116443
GeneTree	ENSGT00760000119186	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119186
H-InvDB	HIX0008248	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0008248
H-InvDB	HIX0125606	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0125606
HGNC	HGNC:16767	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16767
HOGENOM	HOG000231528	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231528&db=HOGENOM6
HOVERGEN	HBG052634	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052634&db=HOVERGEN
InParanoid	Q8TCU5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8TCU5
InterPro	IPR001320	http://www.ebi.ac.uk/interpro/entry/IPR001320
InterPro	IPR001508	http://www.ebi.ac.uk/interpro/entry/IPR001508
InterPro	IPR019594	http://www.ebi.ac.uk/interpro/entry/IPR019594
InterPro	IPR028082	http://www.ebi.ac.uk/interpro/entry/IPR028082
Jabion	116443	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=116443
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:116443	http://www.genome.jp/dbget-bin/www_bget?hsa:116443
KEGG_Orthology	KO:K05213	http://www.genome.jp/dbget-bin/www_bget?KO:K05213
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
KEGG_Pathway	ko05030	http://www.genome.jp/kegg-bin/show_pathway?ko05030
KEGG_Pathway	ko05031	http://www.genome.jp/kegg-bin/show_pathway?ko05031
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
KEGG_Pathway	ko05034	http://www.genome.jp/kegg-bin/show_pathway?ko05034
MIM	606650	http://www.ncbi.nlm.nih.gov/omim/606650
MINT	MINT-6630950	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6630950
OMA	TQFGVMP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TQFGVMP
OrthoDB	EOG091G00PT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00PT
PRINTS	PR00177	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00177
PSORT	swissprot:NMD3A_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NMD3A_HUMAN
PSORT-B	swissprot:NMD3A_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NMD3A_HUMAN
PSORT2	swissprot:NMD3A_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NMD3A_HUMAN
Pfam	PF00060	http://pfam.xfam.org/family/PF00060
Pfam	PF10613	http://pfam.xfam.org/family/PF10613
PharmGKB	PA28983	http://www.pharmgkb.org/do/serve?objId=PA28983&objCls=Gene
Phobius	swissprot:NMD3A_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NMD3A_HUMAN
PhylomeDB	Q8TCU5	http://phylomedb.org/?seqid=Q8TCU5
ProteinModelPortal	Q8TCU5	http://www.proteinmodelportal.org/query/uniprot/Q8TCU5
PubMed	11588171	http://www.ncbi.nlm.nih.gov/pubmed/11588171
PubMed	11735224	http://www.ncbi.nlm.nih.gov/pubmed/11735224
PubMed	11853319	http://www.ncbi.nlm.nih.gov/pubmed/11853319
PubMed	11880201	http://www.ncbi.nlm.nih.gov/pubmed/11880201
PubMed	14684485	http://www.ncbi.nlm.nih.gov/pubmed/14684485
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
RefSeq	NP_597702	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_597702
SMART	SM00079	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00079
SMART	SM00918	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00918
STRING	9606.ENSP00000355155	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000355155&targetmode=cogs
SUPFAM	SSF53822	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822
UCSC	uc004bbp	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004bbp&org=rat
UniGene	Hs.654783	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.654783
UniProtKB	NMD3A_HUMAN	http://www.uniprot.org/uniprot/NMD3A_HUMAN
UniProtKB-AC	Q8TCU5	http://www.uniprot.org/uniprot/Q8TCU5
charge	swissprot:NMD3A_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NMD3A_HUMAN
eggNOG	ENOG410XNUR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNUR
eggNOG	KOG1053	http://eggnogapi.embl.de/nog_data/html/tree/KOG1053
epestfind	swissprot:NMD3A_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NMD3A_HUMAN
garnier	swissprot:NMD3A_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NMD3A_HUMAN
helixturnhelix	swissprot:NMD3A_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NMD3A_HUMAN
hmoment	swissprot:NMD3A_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NMD3A_HUMAN
iep	swissprot:NMD3A_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NMD3A_HUMAN
inforesidue	swissprot:NMD3A_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NMD3A_HUMAN
neXtProt	NX_Q8TCU5	http://www.nextprot.org/db/entry/NX_Q8TCU5
octanol	swissprot:NMD3A_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NMD3A_HUMAN
pepcoil	swissprot:NMD3A_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NMD3A_HUMAN
pepdigest	swissprot:NMD3A_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NMD3A_HUMAN
pepinfo	swissprot:NMD3A_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NMD3A_HUMAN
pepnet	swissprot:NMD3A_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NMD3A_HUMAN
pepstats	swissprot:NMD3A_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NMD3A_HUMAN
pepwheel	swissprot:NMD3A_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NMD3A_HUMAN
pepwindow	swissprot:NMD3A_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NMD3A_HUMAN
sigcleave	swissprot:NMD3A_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NMD3A_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	VATF_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q16864-1; Sequence=Displayed; Name=2; IsoId=Q16864-2; Sequence=VSP_045952; Note=No experimental confirmation available.; 
# AltName	VATF_HUMAN	V-ATPase 14 kDa subunit
# AltName	VATF_HUMAN	Vacuolar proton pump subunit F
# BioGrid	114710	58
# CCDS	CCDS56511	-. [Q16864-2]
# CCDS	CCDS5807	-. [Q16864-1]
# Ensembl	ENST00000249289	ENSP00000249289; ENSG00000128524. [Q16864-1]
# Ensembl	ENST00000492758	ENSP00000417378; ENSG00000128524. [Q16864-2]
# ExpressionAtlas	Q16864	baseline and differential
# FUNCTION	VATF_HUMAN	Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. 
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016469	proton-transporting two-sector ATPase complex; NAS:UniProtKB.
# GO_component	GO:0016471	vacuolar proton-transporting V-type ATPase complex; IDA:UniProtKB.
# GO_component	GO:0033180	proton-transporting V-type ATPase, V1 domain; IEA:InterPro.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0015078	hydrogen ion transmembrane transporter activity; NAS:UniProtKB.
# GO_function	GO:0042624	ATPase activity, uncoupled; NAS:UniProtKB.
# GO_function	GO:0042625	ATPase coupled ion transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
# GO_process	GO:0008286	insulin receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0015991	ATP hydrolysis coupled proton transport; IEA:InterPro.
# GO_process	GO:0015992	proton transport; NAS:UniProtKB.
# GO_process	GO:0033572	transferrin transport; TAS:Reactome.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0090383	phagosome acidification; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.10580	-; 1.
# Genevisible	Q16864	HS
# HGNC	HGNC:16832	ATP6V1F
# IntAct	Q16864	9
# InterPro	IPR005772	ATPase_V1-cplx_fsu_euk
# InterPro	IPR008218	ATPase_V1-cplx_f_g_su
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04966	Collecting duct acid secretion
# KEGG_Pathway	ko05110	Vibrio cholerae infection
# KEGG_Pathway	ko05120	Epithelial cell signaling in Helicobacter pylori infection
# KEGG_Pathway	ko05323	Rheumatoid arthritis
# MIM	607160	gene
# Organism	VATF_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR13861	PTHR13861
# PIR	JC4193	JC4193
# PIRSF	PIRSF015945	ATPase_V1_F_euk
# Pfam	PF01990	ATP-synt_F
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-1222556	ROS, RNS production in response to bacteria
# Reactome	R-HSA-77387	Insulin receptor recycling
# Reactome	R-HSA-917977	Transferrin endocytosis and recycling
# Reactome	R-HSA-983712	Ion channel transport
# RecName	VATF_HUMAN	V-type proton ATPase subunit F
# RefSeq	NP_001185838	NM_001198909.1. [Q16864-2]
# RefSeq	NP_004222	NM_004231.3. [Q16864-1]
# SIMILARITY	Belongs to the V-ATPase F subunit family. {ECO	0000305}.
# SUBUNIT	V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components	 a, c, c', c'' and d). 
# SUPFAM	SSF159468	SSF159468
# TCDB	3.A.2.2	the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily
# TIGRFAMs	TIGR01101	V_ATP_synt_F
# TopDownProteomics	Q16864-1	-. [Q16864-1]
# TopDownProteomics	Q16864-2	-. [Q16864-2]
# UCSC	uc003voc	human. [Q16864-1]
BLAST	swissprot:VATF_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VATF_HUMAN
BioCyc	MetaCyc:HS05192-MONOMER	http://biocyc.org/getid?id=MetaCyc:HS05192-MONOMER
BioCyc	ZFISH:HS05192-MONOMER	http://biocyc.org/getid?id=ZFISH:HS05192-MONOMER
COG	COG1436	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1436
COXPRESdb	9296	http://coxpresdb.jp/data/gene/9296.shtml
CleanEx	HS_ATP6V1F	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP6V1F
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1093/dnares/2.3.107	http://dx.doi.org/10.1093/dnares/2.3.107
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AC025594	http://www.ebi.ac.uk/ena/data/view/AC025594
EMBL	BC104230	http://www.ebi.ac.uk/ena/data/view/BC104230
EMBL	BC104231	http://www.ebi.ac.uk/ena/data/view/BC104231
EMBL	BC107854	http://www.ebi.ac.uk/ena/data/view/BC107854
EMBL	BU956696	http://www.ebi.ac.uk/ena/data/view/BU956696
EMBL	CR456896	http://www.ebi.ac.uk/ena/data/view/CR456896
EMBL	D49400	http://www.ebi.ac.uk/ena/data/view/D49400
Ensembl	ENST00000249289	http://www.ensembl.org/id/ENST00000249289
Ensembl	ENST00000492758	http://www.ensembl.org/id/ENST00000492758
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016469	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016469
GO_component	GO:0016471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016471
GO_component	GO:0033180	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033180
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0015078	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015078
GO_function	GO:0042624	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042624
GO_function	GO:0042625	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042625
GO_function	GO:0046961	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046961
GO_process	GO:0008286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008286
GO_process	GO:0015991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015991
GO_process	GO:0015992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992
GO_process	GO:0033572	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033572
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0090383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090383
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.10580	http://www.cathdb.info/version/latest/superfamily/3.40.50.10580
GeneCards	ATP6V1F	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP6V1F
GeneID	9296	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9296
GeneTree	ENSGT00390000013208	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000013208
HGNC	HGNC:16832	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16832
HOGENOM	HOG000056545	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000056545&db=HOGENOM6
HOVERGEN	HBG004488	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004488&db=HOVERGEN
HPA	CAB009529	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB009529
HPA	HPA048700	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA048700
HPA	HPA062011	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA062011
InParanoid	Q16864	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q16864
IntAct	Q16864	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q16864*
InterPro	IPR005772	http://www.ebi.ac.uk/interpro/entry/IPR005772
InterPro	IPR008218	http://www.ebi.ac.uk/interpro/entry/IPR008218
Jabion	9296	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9296
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:9296	http://www.genome.jp/dbget-bin/www_bget?hsa:9296
KEGG_Orthology	KO:K02151	http://www.genome.jp/dbget-bin/www_bget?KO:K02151
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04966	http://www.genome.jp/kegg-bin/show_pathway?ko04966
KEGG_Pathway	ko05110	http://www.genome.jp/kegg-bin/show_pathway?ko05110
KEGG_Pathway	ko05120	http://www.genome.jp/kegg-bin/show_pathway?ko05120
KEGG_Pathway	ko05323	http://www.genome.jp/kegg-bin/show_pathway?ko05323
MIM	607160	http://www.ncbi.nlm.nih.gov/omim/607160
MINT	MINT-1426240	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1426240
OMA	QNVAEMI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QNVAEMI
OrthoDB	EOG091G0ZUA	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0ZUA
PANTHER	PTHR13861	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13861
PSORT	swissprot:VATF_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VATF_HUMAN
PSORT-B	swissprot:VATF_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VATF_HUMAN
PSORT2	swissprot:VATF_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VATF_HUMAN
Pfam	PF01990	http://pfam.xfam.org/family/PF01990
PharmGKB	PA38421	http://www.pharmgkb.org/do/serve?objId=PA38421&objCls=Gene
Phobius	swissprot:VATF_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VATF_HUMAN
PhylomeDB	Q16864	http://phylomedb.org/?seqid=Q16864
ProteinModelPortal	Q16864	http://www.proteinmodelportal.org/query/uniprot/Q16864
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	8581736	http://www.ncbi.nlm.nih.gov/pubmed/8581736
Reactome	R-HSA-1222556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1222556
Reactome	R-HSA-77387	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-77387
Reactome	R-HSA-917977	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917977
Reactome	R-HSA-983712	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983712
RefSeq	NP_001185838	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001185838
RefSeq	NP_004222	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004222
SMR	Q16864	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q16864
STRING	COG1436	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1436&targetmode=cogs
SUPFAM	SSF159468	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF159468
TCDB	3.A.2.2	http://www.tcdb.org/search/result.php?tc=3.A.2.2
TIGRFAMs	TIGR01101	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01101
UCSC	uc003voc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003voc&org=rat
UniGene	Hs.78089	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.78089
UniProtKB	VATF_HUMAN	http://www.uniprot.org/uniprot/VATF_HUMAN
UniProtKB-AC	Q16864	http://www.uniprot.org/uniprot/Q16864
charge	swissprot:VATF_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VATF_HUMAN
epestfind	swissprot:VATF_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VATF_HUMAN
garnier	swissprot:VATF_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VATF_HUMAN
helixturnhelix	swissprot:VATF_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VATF_HUMAN
hmoment	swissprot:VATF_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VATF_HUMAN
iep	swissprot:VATF_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VATF_HUMAN
inforesidue	swissprot:VATF_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VATF_HUMAN
neXtProt	NX_Q16864	http://www.nextprot.org/db/entry/NX_Q16864
octanol	swissprot:VATF_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VATF_HUMAN
pepcoil	swissprot:VATF_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VATF_HUMAN
pepdigest	swissprot:VATF_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VATF_HUMAN
pepinfo	swissprot:VATF_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VATF_HUMAN
pepnet	swissprot:VATF_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VATF_HUMAN
pepstats	swissprot:VATF_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VATF_HUMAN
pepwheel	swissprot:VATF_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VATF_HUMAN
pepwindow	swissprot:VATF_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VATF_HUMAN
sigcleave	swissprot:VATF_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VATF_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S22AG_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q86VW1-1; Sequence=Displayed; Name=2; IsoId=Q86VW1-2; Sequence=VSP_031336, VSP_031337; Name=3; IsoId=Q86VW1-3; Sequence=VSP_031338; 
# AltName	S22AG_HUMAN	Carnitine transporter 2
# AltName	S22AG_HUMAN	Fly-like putative transporter 2
# AltName	S22AG_HUMAN	Organic cation transporter OKB1
# AltName	S22AG_HUMAN	Organic cation/carnitine transporter 6
# BioGrid	124519	29
# CCDS	CCDS5084	-. [Q86VW1-1]
# CDD	cd06174	MFS
# ChiTaRS	SLC22A16	human
# DrugBank	DB00583	L-Carnitine
# DrugBank	DB00997	Doxorubicin
# Ensembl	ENST00000330550	ENSP00000328583; ENSG00000004809. [Q86VW1-2]
# Ensembl	ENST00000368919	ENSP00000357915; ENSG00000004809. [Q86VW1-1]
# ExpressionAtlas	Q86VW1	baseline and differential
# FUNCTION	S22AG_HUMAN	High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent. {ECO 0000269|PubMed 12089149, ECO 0000269|PubMed 15963465}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IDA:UniProtKB.
# GO_function	GO:0005275	amine transmembrane transporter activity; IDA:MGI.
# GO_function	GO:0015101	organic cation transmembrane transporter activity; IDA:MGI.
# GO_function	GO:0015226	carnitine transmembrane transporter activity; IDA:UniProtKB.
# GO_process	GO:0007275	multicellular organism development; IEA:UniProtKB-KW.
# GO_process	GO:0007283	spermatogenesis; IEA:UniProtKB-KW.
# GO_process	GO:0007338	single fertilization; IMP:UniProtKB.
# GO_process	GO:0015695	organic cation transport; IDA:UniProtKB.
# GO_process	GO:0015879	carnitine transport; IDA:UniProtKB.
# GO_process	GO:0030154	cell differentiation; IEA:UniProtKB-KW.
# GO_process	GO:0030317	flagellated sperm motility; IMP:UniProtKB.
# GO_process	GO:0046717	acid secretion; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0048870	cell motility
# Genevisible	Q86VW1	HS
# HGNC	HGNC:20302	SLC22A16
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	608276	gene
# Organism	S22AG_HUMAN	Homo sapiens (Human)
# PROSITE	PS50850	MFS
# Pfam	PF00083	Sugar_tr
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-549127	Organic cation transport
# RecName	S22AG_HUMAN	Solute carrier family 22 member 16
# RefSeq	NP_149116	NM_033125.3. [Q86VW1-1]
# RefSeq	XP_011534507	XM_011536205.2. [Q86VW1-3]
# SEQUENCE CAUTION	Sequence=BAB71419.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S22AG_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. Cell membrane {ECO 0000269|PubMed 12089149}. Note=Detected in the plasma membrane of Sertoli cells and in the luminal membrane of epithelial cells in the epididymis. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.19.12	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	S22AG_HUMAN	Widely expressed at low levels in adult tissues and fetal brain, lung, liver and kidney. Expressed in testis and epididymis (at protein level). Expressed at lower levels in bone marrow and fetal liver. Expressed in hematopoietic cells, including CD34(+) leukocytes and leukemia cells. Abundantly expressed in ovarian cancer clear-cell adenocarcinoma. Expressed in endometrium (at protein level); highly expressed during the normal secretory phase, but expression is significantly reduced in the proliferative phase. {ECO 0000269|PubMed 12089149, ECO 0000269|PubMed 12372408, ECO 0000269|PubMed 12384147, ECO 0000269|PubMed 15963465, ECO 0000269|PubMed 17197897, ECO 0000269|PubMed 17581421}. 
# UCSC	uc003puf	human. [Q86VW1-1]
# eggNOG	ENOG410IRIC	Eukaryota
# eggNOG	ENOG410YUFN	LUCA
BLAST	swissprot:S22AG_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S22AG_HUMAN
COXPRESdb	85413	http://coxpresdb.jp/data/gene/85413.shtml
CleanEx	HS_SLC22A16	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC22A16
DOI	10.1016/S0006-291X(02)02343-4	http://dx.doi.org/10.1016/S0006-291X(02)02343-4
DOI	10.1016/S0301-472X(02)00901-3	http://dx.doi.org/10.1016/S0301-472X(02)00901-3
DOI	10.1016/j.bbrc.2005.05.174	http://dx.doi.org/10.1016/j.bbrc.2005.05.174
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M203883200	http://dx.doi.org/10.1074/jbc.M203883200
DOI	10.1097/01.pgp.0000225845.67245.b3	http://dx.doi.org/10.1097/01.pgp.0000225845.67245.b3
DOI	10.1097/01.pgp.0000236951.33914.1b	http://dx.doi.org/10.1097/01.pgp.0000236951.33914.1b
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00583	http://www.drugbank.ca/drugs/DB00583
DrugBank	DB00997	http://www.drugbank.ca/drugs/DB00997
EMBL	AB055798	http://www.ebi.ac.uk/ena/data/view/AB055798
EMBL	AC002464	http://www.ebi.ac.uk/ena/data/view/AC002464
EMBL	AC002464	http://www.ebi.ac.uk/ena/data/view/AC002464
EMBL	AC002464	http://www.ebi.ac.uk/ena/data/view/AC002464
EMBL	AF268892	http://www.ebi.ac.uk/ena/data/view/AF268892
EMBL	AK057306	http://www.ebi.ac.uk/ena/data/view/AK057306
EMBL	AL050350	http://www.ebi.ac.uk/ena/data/view/AL050350
EMBL	AL050350	http://www.ebi.ac.uk/ena/data/view/AL050350
EMBL	AY145502	http://www.ebi.ac.uk/ena/data/view/AY145502
EMBL	BC047565	http://www.ebi.ac.uk/ena/data/view/BC047565
EMBL	CH471051	http://www.ebi.ac.uk/ena/data/view/CH471051
Ensembl	ENST00000330550	http://www.ensembl.org/id/ENST00000330550
Ensembl	ENST00000368919	http://www.ensembl.org/id/ENST00000368919
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005275	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005275
GO_function	GO:0015101	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015101
GO_function	GO:0015226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015226
GO_process	GO:0007275	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007275
GO_process	GO:0007283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007283
GO_process	GO:0007338	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007338
GO_process	GO:0015695	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015695
GO_process	GO:0015879	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015879
GO_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GO_process	GO:0030317	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030317
GO_process	GO:0046717	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046717
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GeneCards	SLC22A16	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC22A16
GeneID	85413	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=85413
GeneTree	ENSGT00760000118852	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118852
HGNC	HGNC:20302	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20302
HOVERGEN	HBG108436	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108436&db=HOVERGEN
HPA	HPA036902	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA036902
InParanoid	Q86VW1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q86VW1
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	85413	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=85413
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:85413	http://www.genome.jp/dbget-bin/www_bget?hsa:85413
KEGG_Orthology	KO:K08212	http://www.genome.jp/dbget-bin/www_bget?KO:K08212
MIM	608276	http://www.ncbi.nlm.nih.gov/omim/608276
OMA	SKKEFPC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SKKEFPC
OrthoDB	EOG091G03V1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G03V1
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:S22AG_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S22AG_HUMAN
PSORT-B	swissprot:S22AG_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S22AG_HUMAN
PSORT2	swissprot:S22AG_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S22AG_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
PharmGKB	PA134911502	http://www.pharmgkb.org/do/serve?objId=PA134911502&objCls=Gene
Phobius	swissprot:S22AG_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S22AG_HUMAN
PhylomeDB	Q86VW1	http://phylomedb.org/?seqid=Q86VW1
ProteinModelPortal	Q86VW1	http://www.proteinmodelportal.org/query/uniprot/Q86VW1
PubMed	12089149	http://www.ncbi.nlm.nih.gov/pubmed/12089149
PubMed	12372408	http://www.ncbi.nlm.nih.gov/pubmed/12372408
PubMed	12384147	http://www.ncbi.nlm.nih.gov/pubmed/12384147
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15963465	http://www.ncbi.nlm.nih.gov/pubmed/15963465
PubMed	17197897	http://www.ncbi.nlm.nih.gov/pubmed/17197897
PubMed	17581421	http://www.ncbi.nlm.nih.gov/pubmed/17581421
Reactome	R-HSA-549127	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-549127
RefSeq	NP_149116	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_149116
RefSeq	XP_011534507	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011534507
STRING	9606.ENSP00000357915	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000357915&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.19.12	http://www.tcdb.org/search/result.php?tc=2.A.1.19.12
UCSC	uc003puf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003puf&org=rat
UniGene	Hs.520319	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.520319
UniProtKB	S22AG_HUMAN	http://www.uniprot.org/uniprot/S22AG_HUMAN
UniProtKB-AC	Q86VW1	http://www.uniprot.org/uniprot/Q86VW1
charge	swissprot:S22AG_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S22AG_HUMAN
eggNOG	ENOG410IRIC	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IRIC
eggNOG	ENOG410YUFN	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YUFN
epestfind	swissprot:S22AG_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S22AG_HUMAN
garnier	swissprot:S22AG_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S22AG_HUMAN
helixturnhelix	swissprot:S22AG_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S22AG_HUMAN
hmoment	swissprot:S22AG_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S22AG_HUMAN
iep	swissprot:S22AG_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S22AG_HUMAN
inforesidue	swissprot:S22AG_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S22AG_HUMAN
neXtProt	NX_Q86VW1	http://www.nextprot.org/db/entry/NX_Q86VW1
octanol	swissprot:S22AG_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S22AG_HUMAN
pepcoil	swissprot:S22AG_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S22AG_HUMAN
pepdigest	swissprot:S22AG_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S22AG_HUMAN
pepinfo	swissprot:S22AG_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S22AG_HUMAN
pepnet	swissprot:S22AG_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S22AG_HUMAN
pepstats	swissprot:S22AG_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S22AG_HUMAN
pepwheel	swissprot:S22AG_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S22AG_HUMAN
pepwindow	swissprot:S22AG_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S22AG_HUMAN
sigcleave	swissprot:S22AG_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S22AG_HUMAN
## Database	ID	URL or Descriptions
# AltName	NTCP2_HUMAN	Apical sodium-dependent bile acid transporter
# AltName	NTCP2_HUMAN	Ileal Na(+)/bile acid cotransporter
# AltName	NTCP2_HUMAN	Ileal sodium-dependent bile acid transporter
# AltName	NTCP2_HUMAN	Na(+)-dependent ileal bile acid transporter
# AltName	NTCP2_HUMAN	Sodium/taurocholate cotransporting polypeptide, ileal
# AltName	NTCP2_HUMAN	Solute carrier family 10 member 2
# DISEASE	NTCP2_HUMAN	Primary bile acid malabsorption (PBAM) [MIM 613291]  An intestinal disorder associated with chronic watery diarrhea, excess fecal bile acids, steatorrhea and interruption of the enterohepatic circulation of bile acids. {ECO 0000269|PubMed 9109432}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00091	Cyclosporine
# DrugBank	DB00577	Valaciclovir
# DrugBank	DB00787	Aciclovir
# DrugBank	DB01586	Ursodeoxycholic acid
# DrugBank	DB02659	Cholic Acid
# DrugBank	DB03619	Deoxycholic Acid
# Ensembl	ENST00000245312	ENSP00000245312; ENSG00000125255
# FUNCTION	NTCP2_HUMAN	Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0005902	microvillus; IEA:Ensembl.
# GO_component	GO:0016324	apical plasma membrane; IEA:Ensembl.
# GO_function	NTCP2_HUMAN	GO 0008508 bile acid sodium symporter activity; TAS Reactome.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0015721	bile acid and bile salt transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q12908	HS
# HGNC	HGNC:10906	SLC10A2
# InterPro	IPR002657:BilAc	Na_symport/Acr3
# InterPro	IPR004710:Bilac	Na_transpt
# InterPro	IPR030207	SLC10A2
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H01016	[Gastrointestinal disease] Primary bile acid malabsorption
# KEGG_Pathway	ko04976	Bile secretion
# MIM	601295	gene
# MIM	613291	phenotype
# Organism	NTCP2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10361	PTHR10361
# PANTHER	PTHR10361:SF19	PTHR10361:SF19
# PIR	I38655	I38655
# Pfam	PF01758	SBF
# Proteomes	UP000005640	Chromosome 13
# Reactome	R-HSA-159418	Recycling of bile acids and salts
# RecName	NTCP2_HUMAN	Ileal sodium/bile acid cotransporter
# RefSeq	NP_000443	NM_000452.2
# SIMILARITY	Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	NTCP2_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	NTCP2_HUMAN	Monomer and homodimer. 
# TCDB	2.A.28.1:the bile acid	na(+) symporter (bass) family
# TIGRFAMs	TIGR00841	bass
# UCSC	uc001vpy	human
# eggNOG	COG0385	LUCA
# eggNOG	KOG2718	Eukaryota
BLAST	swissprot:NTCP2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NTCP2_HUMAN
BioCyc	ZFISH:ENSG00000125255-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000125255-MONOMER
COXPRESdb	6555	http://coxpresdb.jp/data/gene/6555.shtml
CleanEx	HS_SLC10A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC10A2
DOI	10.1021/bi049270a	http://dx.doi.org/10.1021/bi049270a
DOI	10.1038/nature02379	http://dx.doi.org/10.1038/nature02379
DOI	10.1073/pnas.182412499	http://dx.doi.org/10.1073/pnas.182412499
DOI	10.1074/jbc.270.45.27228	http://dx.doi.org/10.1074/jbc.270.45.27228
DOI	10.1080/003655201750422693	http://dx.doi.org/10.1080/003655201750422693
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1161/hq1201.100262	http://dx.doi.org/10.1161/hq1201.100262
DOI	10.1172/JCI119355	http://dx.doi.org/10.1172/JCI119355
DrugBank	DB00091	http://www.drugbank.ca/drugs/DB00091
DrugBank	DB00577	http://www.drugbank.ca/drugs/DB00577
DrugBank	DB00787	http://www.drugbank.ca/drugs/DB00787
DrugBank	DB01586	http://www.drugbank.ca/drugs/DB01586
DrugBank	DB02659	http://www.drugbank.ca/drugs/DB02659
DrugBank	DB03619	http://www.drugbank.ca/drugs/DB03619
EMBL	AE014294	http://www.ebi.ac.uk/ena/data/view/AE014294
EMBL	AL161771	http://www.ebi.ac.uk/ena/data/view/AL161771
EMBL	BC130521	http://www.ebi.ac.uk/ena/data/view/BC130521
EMBL	BC130523	http://www.ebi.ac.uk/ena/data/view/BC130523
EMBL	CH471085	http://www.ebi.ac.uk/ena/data/view/CH471085
EMBL	U10417	http://www.ebi.ac.uk/ena/data/view/U10417
EMBL	U67669	http://www.ebi.ac.uk/ena/data/view/U67669
EMBL	U67670	http://www.ebi.ac.uk/ena/data/view/U67670
EMBL	U67671	http://www.ebi.ac.uk/ena/data/view/U67671
EMBL	U67672	http://www.ebi.ac.uk/ena/data/view/U67672
EMBL	U67673	http://www.ebi.ac.uk/ena/data/view/U67673
EMBL	U67674	http://www.ebi.ac.uk/ena/data/view/U67674
EMBL	Z54350	http://www.ebi.ac.uk/ena/data/view/Z54350
Ensembl	ENST00000245312	http://www.ensembl.org/id/ENST00000245312
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005902
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_function	GO:0008508	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008508
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0015721	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015721
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC10A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC10A2
GeneID	6555	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6555
GeneTree	ENSGT00550000074505	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074505
HGNC	HGNC:10906	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10906
HOGENOM	HOG000234524	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234524&db=HOGENOM6
HOVERGEN	HBG006537	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006537&db=HOVERGEN
HPA	HPA004795	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA004795
InParanoid	Q12908	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q12908
InterPro	IPR002657	http://www.ebi.ac.uk/interpro/entry/IPR002657
InterPro	IPR004710	http://www.ebi.ac.uk/interpro/entry/IPR004710
InterPro	IPR030207	http://www.ebi.ac.uk/interpro/entry/IPR030207
Jabion	6555	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6555
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H01016	http://www.genome.jp/dbget-bin/www_bget?H01016
KEGG_Gene	hsa:6555	http://www.genome.jp/dbget-bin/www_bget?hsa:6555
KEGG_Orthology	KO:K14342	http://www.genome.jp/dbget-bin/www_bget?KO:K14342
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
MIM	601295	http://www.ncbi.nlm.nih.gov/omim/601295
MIM	613291	http://www.ncbi.nlm.nih.gov/omim/613291
OMA	NSCVDNA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NSCVDNA
OrthoDB	EOG091G0GT5	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0GT5
PANTHER	PTHR10361	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10361
PANTHER	PTHR10361:SF19	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10361:SF19
PSORT	swissprot:NTCP2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NTCP2_HUMAN
PSORT-B	swissprot:NTCP2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NTCP2_HUMAN
PSORT2	swissprot:NTCP2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NTCP2_HUMAN
Pfam	PF01758	http://pfam.xfam.org/family/PF01758
PharmGKB	PA318	http://www.pharmgkb.org/do/serve?objId=PA318&objCls=Gene
Phobius	swissprot:NTCP2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NTCP2_HUMAN
PhylomeDB	Q12908	http://phylomedb.org/?seqid=Q12908
ProteinModelPortal	Q12908	http://www.proteinmodelportal.org/query/uniprot/Q12908
PubMed	11589382	http://www.ncbi.nlm.nih.gov/pubmed/11589382
PubMed	11742882	http://www.ncbi.nlm.nih.gov/pubmed/11742882
PubMed	12364586	http://www.ncbi.nlm.nih.gov/pubmed/12364586
PubMed	15057823	http://www.ncbi.nlm.nih.gov/pubmed/15057823
PubMed	15350125	http://www.ncbi.nlm.nih.gov/pubmed/15350125
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	7592981	http://www.ncbi.nlm.nih.gov/pubmed/7592981
PubMed	9109432	http://www.ncbi.nlm.nih.gov/pubmed/9109432
Reactome	R-HSA-159418	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-159418
RefSeq	NP_000443	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000443
STRING	9606.ENSP00000245312	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000245312&targetmode=cogs
TCDB	2.A.28.1	http://www.tcdb.org/search/result.php?tc=2.A.28.1
TIGRFAMs	TIGR00841	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00841
UCSC	uc001vpy	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001vpy&org=rat
UniGene	Hs.194783	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.194783
UniProtKB	NTCP2_HUMAN	http://www.uniprot.org/uniprot/NTCP2_HUMAN
UniProtKB-AC	Q12908	http://www.uniprot.org/uniprot/Q12908
charge	swissprot:NTCP2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NTCP2_HUMAN
eggNOG	COG0385	http://eggnogapi.embl.de/nog_data/html/tree/COG0385
eggNOG	KOG2718	http://eggnogapi.embl.de/nog_data/html/tree/KOG2718
epestfind	swissprot:NTCP2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NTCP2_HUMAN
garnier	swissprot:NTCP2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NTCP2_HUMAN
helixturnhelix	swissprot:NTCP2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NTCP2_HUMAN
hmoment	swissprot:NTCP2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NTCP2_HUMAN
iep	swissprot:NTCP2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NTCP2_HUMAN
inforesidue	swissprot:NTCP2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NTCP2_HUMAN
neXtProt	NX_Q12908	http://www.nextprot.org/db/entry/NX_Q12908
octanol	swissprot:NTCP2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NTCP2_HUMAN
pepcoil	swissprot:NTCP2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NTCP2_HUMAN
pepdigest	swissprot:NTCP2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NTCP2_HUMAN
pepinfo	swissprot:NTCP2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NTCP2_HUMAN
pepnet	swissprot:NTCP2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NTCP2_HUMAN
pepstats	swissprot:NTCP2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NTCP2_HUMAN
pepwheel	swissprot:NTCP2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NTCP2_HUMAN
pepwindow	swissprot:NTCP2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NTCP2_HUMAN
sigcleave	swissprot:NTCP2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NTCP2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SO3A1_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=OATP3A1-v1; IsoId=Q9UIG8-1; Sequence=Displayed; Name=2; Synonyms=OATP3A1-v2; IsoId=Q9UIG8-2; Sequence=VSP_036837, VSP_036838; Name=3; IsoId=Q9UIG8-3; Sequence=VSP_036834, VSP_036835, VSP_036836; Note=No experimental confirmation available.; Name=4; IsoId=Q9UIG8-4; Sequence=VSP_036833; Note=No experimental confirmation available.; 
# AltName	SO3A1_HUMAN	Organic anion transporter polypeptide-related protein 3
# AltName	SO3A1_HUMAN	Organic anion-transporting polypeptide D
# AltName	SO3A1_HUMAN	PGE1 transporter
# AltName	SO3A1_HUMAN	Sodium-independent organic anion transporter D
# AltName	SO3A1_HUMAN	Solute carrier family 21 member 11
# BIOPHYSICOCHEMICAL PROPERTIES	SO3A1_HUMAN	Kinetic parameters  KM=101 nM for PGE1 (isoform 1) {ECO 0000269|PubMed 16971491}; KM=218 nM for PGE1 (isoform 2) {ECO 0000269|PubMed 16971491}; KM=219 nM for PGE2 (isoform 1) {ECO 0000269|PubMed 16971491}; KM=371 nM for PGE2 (isoform 2) {ECO 0000269|PubMed 16971491}; 
# CCDS	CCDS10371	-. [Q9UIG8-1]
# CCDS	CCDS45354	-. [Q9UIG8-2]
# CDD	cd06174	MFS
# ChiTaRS	SLCO3A1	human
# DrugBank	DB00286	Conjugated Estrogens
# DrugBank	DB00345	Aminohippurate
# DrugBank	DB00563	Methotrexate
# DrugBank	DB00770	Alprostadil
# DrugBank	DB00917	Dinoprostone
# DrugBank	DB01053	Benzylpenicillin
# DrugBank	DB01088	Iloprost
# DrugBank	DB01160	Dinoprost Tromethamine
# Ensembl	ENST00000318445	ENSP00000320634; ENSG00000176463. [Q9UIG8-1]
# Ensembl	ENST00000424469	ENSP00000387846; ENSG00000176463. [Q9UIG8-2]
# ExpressionAtlas	Q9UIG8	baseline and differential
# FUNCTION	SO3A1_HUMAN	Mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate (PubMed 10873595). Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3- sulfate, taurocholate, digoxin nor DHEAS (PubMed 16971491). {ECO 0000269|PubMed 10873595, ECO 0000269|PubMed 16971491}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0015347	sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0015732	prostaglandin transport; IBA:GO_Central.
# GO_process	GO:0043252	sodium-independent organic anion transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q9UIG8	HS
# HGNC	HGNC:10952	SLCO3A1
# InterPro	IPR002350	Kazal_dom
# InterPro	IPR004156	OA_transporter
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02001	Solute carrier family
# MIM	612435	gene
# Organism	SO3A1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11388	PTHR11388
# PROSITE	PS51465	KAZAL_2
# Pfam	PF03137	OATP
# Pfam	PF07648	Kazal_2
# Proteomes	UP000005640	Chromosome 15
# Reactome	R-HSA-879518	Transport of organic anions
# RecName	SO3A1_HUMAN	Solute carrier organic anion transporter family member 3A1
# RefSeq	NP_001138516	NM_001145044.1. [Q9UIG8-2]
# RefSeq	NP_037404	NM_013272.3. [Q9UIG8-1]
# SIMILARITY	Belongs to the organo anion transporter (TC 2.A.60) family. {ECO	0000305}. 
# SIMILARITY	Contains 1 Kazal-like domain. {ECO:0000255|PROSITE- ProRule	PRU00798}.
# SUBCELLULAR LOCATION	SO3A1_HUMAN	Cell membrane; Multi-pass membrane protein. 
# SUPFAM	SSF103473	SSF103473; 4
# TCDB	2.A.60.1.18	the organo anion transporter (oat) family
# TIGRFAMs	TIGR00805	oat
# TISSUE SPECIFICITY	Ubiquitous. Highly expressed in spleen and leukocytes. Generally the expression of isoform 1 is higher than that of isoform 2. Isoform 2 is particularly abundant in testis and brain. In testis, isoform 1 is detected in spermatogonia at different stages and absent from Sertoli cells, while isoform 2 is present in both (at protein level). Expressed in the choroid plexus epithelium, isoform 1 being localized at the basolateral membrane and isoform 2 at the apical one, as well as in the subapical intracellular vesicular compartments. Differential expression of both isoforms is also observed in other brain region: isoform 1 is very abundant in the gray matter of the frontal cortex, but is not associated with neuronal cell bodies. Not detected in the white matter. In contrast, isoform 2 is associated with neuronal bodies and axons in both the gray and the white matters of the frontal cortex. {ECO	0000269|PubMed:16971491}. 
# UCSC	uc002bqx	human. [Q9UIG8-1]
# eggNOG	ENOG410XRSF	LUCA
# eggNOG	KOG3626	Eukaryota
BLAST	swissprot:SO3A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SO3A1_HUMAN
BioCyc	ZFISH:ENSG00000176463-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000176463-MONOMER
COXPRESdb	28232	http://coxpresdb.jp/data/gene/28232.shtml
CleanEx	HS_SLCO3A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLCO3A1
DOI	10.1006/bbrc.2000.2922	http://dx.doi.org/10.1006/bbrc.2000.2922
DOI	10.1038/nature04601	http://dx.doi.org/10.1038/nature04601
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1152/ajpcell.00597.2005	http://dx.doi.org/10.1152/ajpcell.00597.2005
DrugBank	DB00286	http://www.drugbank.ca/drugs/DB00286
DrugBank	DB00345	http://www.drugbank.ca/drugs/DB00345
DrugBank	DB00563	http://www.drugbank.ca/drugs/DB00563
DrugBank	DB00770	http://www.drugbank.ca/drugs/DB00770
DrugBank	DB00917	http://www.drugbank.ca/drugs/DB00917
DrugBank	DB01053	http://www.drugbank.ca/drugs/DB01053
DrugBank	DB01088	http://www.drugbank.ca/drugs/DB01088
DrugBank	DB01160	http://www.drugbank.ca/drugs/DB01160
EMBL	AB031050	http://www.ebi.ac.uk/ena/data/view/AB031050
EMBL	AC104020	http://www.ebi.ac.uk/ena/data/view/AC104020
EMBL	AC104236	http://www.ebi.ac.uk/ena/data/view/AC104236
EMBL	AC113190	http://www.ebi.ac.uk/ena/data/view/AC113190
EMBL	AC116903	http://www.ebi.ac.uk/ena/data/view/AC116903
EMBL	AC135996	http://www.ebi.ac.uk/ena/data/view/AC135996
EMBL	AF187816	http://www.ebi.ac.uk/ena/data/view/AF187816
EMBL	AF205074	http://www.ebi.ac.uk/ena/data/view/AF205074
EMBL	AK057031	http://www.ebi.ac.uk/ena/data/view/AK057031
EMBL	AK097797	http://www.ebi.ac.uk/ena/data/view/AK097797
EMBL	AK290872	http://www.ebi.ac.uk/ena/data/view/AK290872
EMBL	BC000585	http://www.ebi.ac.uk/ena/data/view/BC000585
EMBL	FJ515841	http://www.ebi.ac.uk/ena/data/view/FJ515841
Ensembl	ENST00000318445	http://www.ensembl.org/id/ENST00000318445
Ensembl	ENST00000424469	http://www.ensembl.org/id/ENST00000424469
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0015347	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015347
GO_process	GO:0015732	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015732
GO_process	GO:0043252	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043252
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLCO3A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLCO3A1
GeneID	28232	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=28232
GeneTree	ENSGT00760000119014	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119014
H-InvDB	HIX0018979	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0018979
HGNC	HGNC:10952	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10952
HOVERGEN	HBG098539	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG098539&db=HOVERGEN
InParanoid	Q9UIG8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UIG8
IntAct	Q9UIG8	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9UIG8*
InterPro	IPR002350	http://www.ebi.ac.uk/interpro/entry/IPR002350
InterPro	IPR004156	http://www.ebi.ac.uk/interpro/entry/IPR004156
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	28232	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=28232
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:28232	http://www.genome.jp/dbget-bin/www_bget?hsa:28232
KEGG_Orthology	KO:K14353	http://www.genome.jp/dbget-bin/www_bget?KO:K14353
MIM	612435	http://www.ncbi.nlm.nih.gov/omim/612435
OMA	LKSSAFV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LKSSAFV
OrthoDB	EOG091G03A9	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G03A9
PANTHER	PTHR11388	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11388
PROSITE	PS51465	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51465
PSORT	swissprot:SO3A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SO3A1_HUMAN
PSORT-B	swissprot:SO3A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SO3A1_HUMAN
PSORT2	swissprot:SO3A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SO3A1_HUMAN
Pfam	PF03137	http://pfam.xfam.org/family/PF03137
Pfam	PF07648	http://pfam.xfam.org/family/PF07648
PharmGKB	PA35837	http://www.pharmgkb.org/do/serve?objId=PA35837&objCls=Gene
Phobius	swissprot:SO3A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SO3A1_HUMAN
PhylomeDB	Q9UIG8	http://phylomedb.org/?seqid=Q9UIG8
ProteinModelPortal	Q9UIG8	http://www.proteinmodelportal.org/query/uniprot/Q9UIG8
PubMed	10873595	http://www.ncbi.nlm.nih.gov/pubmed/10873595
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16572171	http://www.ncbi.nlm.nih.gov/pubmed/16572171
PubMed	16971491	http://www.ncbi.nlm.nih.gov/pubmed/16971491
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
Reactome	R-HSA-879518	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-879518
RefSeq	NP_001138516	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001138516
RefSeq	NP_037404	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_037404
STRING	9606.ENSP00000320634	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000320634&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.60.1.18	http://www.tcdb.org/search/result.php?tc=2.A.60.1.18
TIGRFAMs	TIGR00805	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00805
UCSC	uc002bqx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002bqx&org=rat
UniGene	Hs.311187	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.311187
UniGene	Hs.707541	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.707541
UniProtKB	SO3A1_HUMAN	http://www.uniprot.org/uniprot/SO3A1_HUMAN
UniProtKB-AC	Q9UIG8	http://www.uniprot.org/uniprot/Q9UIG8
charge	swissprot:SO3A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SO3A1_HUMAN
eggNOG	ENOG410XRSF	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRSF
eggNOG	KOG3626	http://eggnogapi.embl.de/nog_data/html/tree/KOG3626
epestfind	swissprot:SO3A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SO3A1_HUMAN
garnier	swissprot:SO3A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SO3A1_HUMAN
helixturnhelix	swissprot:SO3A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SO3A1_HUMAN
hmoment	swissprot:SO3A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SO3A1_HUMAN
iep	swissprot:SO3A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SO3A1_HUMAN
inforesidue	swissprot:SO3A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SO3A1_HUMAN
neXtProt	NX_Q9UIG8	http://www.nextprot.org/db/entry/NX_Q9UIG8
octanol	swissprot:SO3A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SO3A1_HUMAN
pepcoil	swissprot:SO3A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SO3A1_HUMAN
pepdigest	swissprot:SO3A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SO3A1_HUMAN
pepinfo	swissprot:SO3A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SO3A1_HUMAN
pepnet	swissprot:SO3A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SO3A1_HUMAN
pepstats	swissprot:SO3A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SO3A1_HUMAN
pepwheel	swissprot:SO3A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SO3A1_HUMAN
pepwindow	swissprot:SO3A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SO3A1_HUMAN
sigcleave	swissprot:SO3A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SO3A1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	MRP3_HUMAN	Event=Alternative splicing; Named isoforms=5; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=MRP3; IsoId=O15438-1; Sequence=Displayed; Name=2; Synonyms=MRP3A; IsoId=O15438-2; Sequence=VSP_000042; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; Synonyms=MRP3B; IsoId=O15438-3; Sequence=VSP_000040, VSP_000041; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=4; Synonyms=MRP3S1; IsoId=O15438-4; Sequence=VSP_043864; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.; Name=5; IsoId=O15438-5; Sequence=VSP_039041, VSP_039042; Note=No experimental confirmation available.; 
# AltName	MRP3_HUMAN	ATP-binding cassette sub-family C member 3
# AltName	MRP3_HUMAN	Multi-specific organic anion transporter D
# AltName	MRP3_HUMAN	Multidrug resistance-associated protein 3
# BioGrid	114255	9
# CCDS	CCDS32681	-. [O15438-1]
# CCDS	CCDS45739	-. [O15438-5]
# ChiTaRS	ABCC3	human
# DrugBank	DB00091	Cyclosporine
# DrugBank	DB00143	Glutathione
# DrugBank	DB00158	Folic Acid
# DrugBank	DB00257	Clotrimazole
# DrugBank	DB00286	Conjugated Estrogens
# DrugBank	DB00328	Indomethacin
# DrugBank	DB00338	Omeprazole
# DrugBank	DB00515	Cisplatin
# DrugBank	DB00541	Vincristine
# DrugBank	DB00544	Fluorouracil
# DrugBank	DB00563	Methotrexate
# DrugBank	DB00650	Leucovorin
# DrugBank	DB00661	Verapamil
# DrugBank	DB00709	Lamivudine
# DrugBank	DB00773	Etoposide
# DrugBank	DB00973	Ezetimibe
# DrugBank	DB00997	Doxorubicin
# DrugBank	DB01011	Metyrapone
# DrugBank	DB01016	Glyburide
# DrugBank	DB01032	Probenecid
# DrugBank	DB01045	Rifampicin
# DrugBank	DB01115	Nifedipine
# DrugBank	DB01138	Sulfinpyrazone
# DrugBank	DB01174	Phenobarbital
# DrugBank	DB02659	Cholic Acid
# DrugBank	DB08884	Gadoxetate
# Ensembl	ENST00000285238	ENSP00000285238; ENSG00000108846. [O15438-1]
# Ensembl	ENST00000427699	ENSP00000395160; ENSG00000108846. [O15438-5]
# Ensembl	ENST00000502426	ENSP00000427073; ENSG00000108846. [O15438-3]
# Ensembl	ENST00000505699	ENSP00000427521; ENSG00000108846. [O15438-2]
# ExpressionAtlas	O15438	baseline and differential
# FUNCTION	MRP3_HUMAN	May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_function	GO:0005524	ATP binding; TAS:ProtInc.
# GO_function	GO:0008514	organic anion transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0015432	bile acid-exporting ATPase activity; TAS:Reactome.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; TAS:ProtInc.
# GO_function	GO:0043225	ATPase-coupled anion transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0015721	bile acid and bile salt transport; TAS:Reactome.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 2.
# Genevisible	O15438	HS
# HGNC	HGNC:54	ABCC3
# IntAct	O15438	5
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR005292	Multidrug-R_assoc
# InterPro	IPR011527	ABC1_TM_dom
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR027417	P-loop_NTPase
# InterPro	IPR030242	ABCC3
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko02010	ABC transporters
# KEGG_Pathway	ko04976	Bile secretion
# MIM	604323	gene
# Organism	MRP3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR24223:SF221	PTHR24223:SF221; 2
# PIR	JE0336	JE0336
# PROSITE	PS00211	ABC_TRANSPORTER_1; 2
# PROSITE	PS50893	ABC_TRANSPORTER_2; 2
# PROSITE	PS50929	ABC_TM1F; 2
# Pfam	PF00005	ABC_tran; 2
# Pfam	PF00664	ABC_membrane; 2
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-159418	Recycling of bile acids and salts
# Reactome	R-HSA-382556	ABC-family proteins mediated transport
# RecName	MRP3_HUMAN	Canalicular multispecific organic anion transporter 2
# RefSeq	NP_001137542	NM_001144070.1. [O15438-5]
# RefSeq	NP_003777	NM_003786.3. [O15438-1]
# SEQUENCE CAUTION	Sequence=AAB71756.1; Type=Frameshift; Positions=1334, 1338; Evidence={ECO:0000305}; Sequence=AAD01430.1; Type=Frameshift; Positions=355, 359, 361; Evidence={ECO	0000305}; Sequence=AAD38185.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; 
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 2 ABC transmembrane type-1 domains. {ECO:0000255|PROSITE-ProRule	PRU00441}. 
# SIMILARITY	Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA; 2
# SUBCELLULAR LOCATION	MRP3_HUMAN	Membrane; Multi-pass membrane protein. 
# SUPFAM	SSF52540	SSF52540; 2
# SUPFAM	SSF90123	SSF90123; 2
# TCDB	3.A.1.208	the atp-binding cassette (abc) superfamily
# TIGRFAMs	TIGR00957	MRP_assoc_pro
# TISSUE SPECIFICITY	MRP3_HUMAN	Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney. 
# UCSC	uc002isk	human. [O15438-1]
# WEB RESOURCE	MRP3_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=O15438";
# eggNOG	COG1132	LUCA
# eggNOG	KOG0054	Eukaryota
BLAST	swissprot:MRP3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MRP3_HUMAN
BioCyc	ZFISH:ENSG00000108846-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000108846-MONOMER
COXPRESdb	8714	http://coxpresdb.jp/data/gene/8714.shtml
CleanEx	HS_ABCC3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCC3
DOI	10.1002/hep.510290404	http://dx.doi.org/10.1002/hep.510290404
DOI	10.1006/bbrc.1998.9546	http://dx.doi.org/10.1006/bbrc.1998.9546
DOI	10.1016/S0005-2736(98)00233-8	http://dx.doi.org/10.1016/S0005-2736(98)00233-8
DOI	10.1016/S0014-5793(98)00899-0	http://dx.doi.org/10.1016/S0014-5793(98)00899-0
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1093/jnci/90.22.1735	http://dx.doi.org/10.1093/jnci/90.22.1735
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/gb-2004-5-2-r8	http://dx.doi.org/10.1186/gb-2004-5-2-r8
DrugBank	DB00091	http://www.drugbank.ca/drugs/DB00091
DrugBank	DB00143	http://www.drugbank.ca/drugs/DB00143
DrugBank	DB00158	http://www.drugbank.ca/drugs/DB00158
DrugBank	DB00257	http://www.drugbank.ca/drugs/DB00257
DrugBank	DB00286	http://www.drugbank.ca/drugs/DB00286
DrugBank	DB00328	http://www.drugbank.ca/drugs/DB00328
DrugBank	DB00338	http://www.drugbank.ca/drugs/DB00338
DrugBank	DB00515	http://www.drugbank.ca/drugs/DB00515
DrugBank	DB00541	http://www.drugbank.ca/drugs/DB00541
DrugBank	DB00544	http://www.drugbank.ca/drugs/DB00544
DrugBank	DB00563	http://www.drugbank.ca/drugs/DB00563
DrugBank	DB00650	http://www.drugbank.ca/drugs/DB00650
DrugBank	DB00661	http://www.drugbank.ca/drugs/DB00661
DrugBank	DB00709	http://www.drugbank.ca/drugs/DB00709
DrugBank	DB00773	http://www.drugbank.ca/drugs/DB00773
DrugBank	DB00973	http://www.drugbank.ca/drugs/DB00973
DrugBank	DB00997	http://www.drugbank.ca/drugs/DB00997
DrugBank	DB01011	http://www.drugbank.ca/drugs/DB01011
DrugBank	DB01016	http://www.drugbank.ca/drugs/DB01016
DrugBank	DB01032	http://www.drugbank.ca/drugs/DB01032
DrugBank	DB01045	http://www.drugbank.ca/drugs/DB01045
DrugBank	DB01115	http://www.drugbank.ca/drugs/DB01115
DrugBank	DB01138	http://www.drugbank.ca/drugs/DB01138
DrugBank	DB01174	http://www.drugbank.ca/drugs/DB01174
DrugBank	DB02659	http://www.drugbank.ca/drugs/DB02659
DrugBank	DB08884	http://www.drugbank.ca/drugs/DB08884
EMBL	AB010887	http://www.ebi.ac.uk/ena/data/view/AB010887
EMBL	AC004590	http://www.ebi.ac.uk/ena/data/view/AC004590
EMBL	AC005921	http://www.ebi.ac.uk/ena/data/view/AC005921
EMBL	AF009670	http://www.ebi.ac.uk/ena/data/view/AF009670
EMBL	AF083552	http://www.ebi.ac.uk/ena/data/view/AF083552
EMBL	AF085690	http://www.ebi.ac.uk/ena/data/view/AF085690
EMBL	AF085691	http://www.ebi.ac.uk/ena/data/view/AF085691
EMBL	AF085692	http://www.ebi.ac.uk/ena/data/view/AF085692
EMBL	AF104943	http://www.ebi.ac.uk/ena/data/view/AF104943
EMBL	AF154001	http://www.ebi.ac.uk/ena/data/view/AF154001
EMBL	BC046126	http://www.ebi.ac.uk/ena/data/view/BC046126
EMBL	BC137347	http://www.ebi.ac.uk/ena/data/view/BC137347
EMBL	BC137348	http://www.ebi.ac.uk/ena/data/view/BC137348
EMBL	CH471109	http://www.ebi.ac.uk/ena/data/view/CH471109
EMBL	CH471109	http://www.ebi.ac.uk/ena/data/view/CH471109
EMBL	CH471109	http://www.ebi.ac.uk/ena/data/view/CH471109
EMBL	U83659	http://www.ebi.ac.uk/ena/data/view/U83659
EMBL	Y17151	http://www.ebi.ac.uk/ena/data/view/Y17151
Ensembl	ENST00000285238	http://www.ensembl.org/id/ENST00000285238
Ensembl	ENST00000427699	http://www.ensembl.org/id/ENST00000427699
Ensembl	ENST00000502426	http://www.ensembl.org/id/ENST00000502426
Ensembl	ENST00000505699	http://www.ensembl.org/id/ENST00000505699
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0008514	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008514
GO_function	GO:0015432	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015432
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GO_function	GO:0043225	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043225
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0015721	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015721
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCC3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCC3
GeneID	8714	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8714
GeneTree	ENSGT00860000133687	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00860000133687
HGNC	HGNC:54	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:54
HOVERGEN	HBG108314	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108314&db=HOVERGEN
HPA	CAB037136	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB037136
HPA	HPA048483	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA048483
InParanoid	O15438	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O15438
IntAct	O15438	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O15438*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR005292	http://www.ebi.ac.uk/interpro/entry/IPR005292
InterPro	IPR011527	http://www.ebi.ac.uk/interpro/entry/IPR011527
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
InterPro	IPR030242	http://www.ebi.ac.uk/interpro/entry/IPR030242
Jabion	8714	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=8714
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:8714	http://www.genome.jp/dbget-bin/www_bget?hsa:8714
KEGG_Orthology	KO:K05667	http://www.genome.jp/dbget-bin/www_bget?KO:K05667
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
MIM	604323	http://www.ncbi.nlm.nih.gov/omim/604323
OMA	LIDEPEC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LIDEPEC
OrthoDB	EOG091G00IN	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00IN
PANTHER	PTHR24223:SF221	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24223:SF221
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PROSITE	PS50929	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929
PSORT	swissprot:MRP3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MRP3_HUMAN
PSORT-B	swissprot:MRP3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MRP3_HUMAN
PSORT2	swissprot:MRP3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MRP3_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF00664	http://pfam.xfam.org/family/PF00664
PharmGKB	PA376	http://www.pharmgkb.org/do/serve?objId=PA376&objCls=Gene
Phobius	swissprot:MRP3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MRP3_HUMAN
PhylomeDB	O15438	http://phylomedb.org/?seqid=O15438
ProteinModelPortal	O15438	http://www.proteinmodelportal.org/query/uniprot/O15438
PubMed	10094960	http://www.ncbi.nlm.nih.gov/pubmed/10094960
PubMed	14759258	http://www.ncbi.nlm.nih.gov/pubmed/14759258
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	9270026	http://www.ncbi.nlm.nih.gov/pubmed/9270026
PubMed	9738950	http://www.ncbi.nlm.nih.gov/pubmed/9738950
PubMed	9813153	http://www.ncbi.nlm.nih.gov/pubmed/9813153
PubMed	9827529	http://www.ncbi.nlm.nih.gov/pubmed/9827529
PubMed	9889399	http://www.ncbi.nlm.nih.gov/pubmed/9889399
Reactome	R-HSA-159418	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-159418
Reactome	R-HSA-382556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-382556
RefSeq	NP_001137542	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001137542
RefSeq	NP_003777	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003777
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	O15438	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O15438
STRING	9606.ENSP00000285238	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000285238&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
SUPFAM	SSF90123	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123
TCDB	3.A.1.208	http://www.tcdb.org/search/result.php?tc=3.A.1.208
TIGRFAMs	TIGR00957	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00957
UCSC	uc002isk	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002isk&org=rat
UniGene	Hs.463421	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.463421
UniProtKB	MRP3_HUMAN	http://www.uniprot.org/uniprot/MRP3_HUMAN
UniProtKB-AC	O15438	http://www.uniprot.org/uniprot/O15438
charge	swissprot:MRP3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MRP3_HUMAN
eggNOG	COG1132	http://eggnogapi.embl.de/nog_data/html/tree/COG1132
eggNOG	KOG0054	http://eggnogapi.embl.de/nog_data/html/tree/KOG0054
epestfind	swissprot:MRP3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MRP3_HUMAN
garnier	swissprot:MRP3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MRP3_HUMAN
helixturnhelix	swissprot:MRP3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MRP3_HUMAN
hmoment	swissprot:MRP3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MRP3_HUMAN
iep	swissprot:MRP3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MRP3_HUMAN
inforesidue	swissprot:MRP3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MRP3_HUMAN
neXtProt	NX_O15438	http://www.nextprot.org/db/entry/NX_O15438
octanol	swissprot:MRP3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MRP3_HUMAN
pepcoil	swissprot:MRP3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MRP3_HUMAN
pepdigest	swissprot:MRP3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MRP3_HUMAN
pepinfo	swissprot:MRP3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MRP3_HUMAN
pepnet	swissprot:MRP3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MRP3_HUMAN
pepstats	swissprot:MRP3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MRP3_HUMAN
pepwheel	swissprot:MRP3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MRP3_HUMAN
pepwindow	swissprot:MRP3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MRP3_HUMAN
sigcleave	swissprot:MRP3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MRP3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	NAC3_HUMAN	Event=Alternative splicing; Named isoforms=7; Name=3; Synonyms=NCX3.3; IsoId=P57103-1; Sequence=Displayed; Name=2; Synonyms=NCX3.2; IsoId=P57103-2; Sequence=VSP_008116; Name=4; Synonyms=NCX3.4; IsoId=P57103-3; Sequence=VSP_008117, VSP_008118; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.; Name=5; Synonyms=NCX3-tN.1; IsoId=P57103-4; Sequence=VSP_043125; Note=Expressed in fetal brain.; Name=6; Synonyms=NCX3-tN.2; IsoId=P57103-5; Sequence=VSP_043126, VSP_008116; Note=Expressed in fetal brain.; Name=7; IsoId=P57103-6; Sequence=VSP_043850; Name=8; IsoId=P57103-7; Sequence=VSP_044502; 
# AltName	NAC3_HUMAN	Na(+)/Ca(2+)-exchange protein 3
# AltName	NAC3_HUMAN	Solute carrier family 8 member 3
# BioGrid	112437	8
# CCDS	CCDS35498	-. [P57103-1]
# CCDS	CCDS41967	-. [P57103-4]
# CCDS	CCDS45131	-. [P57103-5]
# CCDS	CCDS53904	-. [P57103-6]
# CCDS	CCDS9799	-. [P57103-7]
# CCDS	CCDS9800	-. [P57103-2]
# ChiTaRS	SLC8A3	human
# DEVELOPMENTAL STAGE	Up-regulated during in vitro differentiation of oligodendrocytes (at protein level). Up-regulated during in vitro differentiation of oligodendrocytes. {ECO:0000269|PubMed	21959935}. 
# DOMAIN	NAC3_HUMAN	The cytoplasmic Calx-beta domains bind the regulatory Ca(2+). The first Calx-beta domain can bind up to four Ca(2+) ions. The second domain can bind another two Ca(2+) ions that are essential for calcium-regulated ion exchange. {ECO 0000250|UniProtKB P23685}. 
# ENZYME REGULATION	Calcium transport is down-regulated by Na(+) and stimulated by Ca(2+). {ECO:0000250|UniProtKB	P70549}. 
# Ensembl	ENST00000216568	ENSP00000216568; ENSG00000100678. [P57103-5]
# Ensembl	ENST00000356921	ENSP00000349392; ENSG00000100678. [P57103-2]
# Ensembl	ENST00000357887	ENSP00000350560; ENSG00000100678. [P57103-7]
# Ensembl	ENST00000381269	ENSP00000370669; ENSG00000100678. [P57103-1]
# Ensembl	ENST00000394330	ENSP00000377863; ENSG00000100678. [P57103-4]
# Ensembl	ENST00000494208	ENSP00000436332; ENSG00000100678. [P57103-3]
# Ensembl	ENST00000528359	ENSP00000433531; ENSG00000100678. [P57103-7]
# Ensembl	ENST00000534137	ENSP00000436688; ENSG00000100678. [P57103-6]
# ExpressionAtlas	P57103	baseline and differential
# FUNCTION	NAC3_HUMAN	Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity). Required for normal oligodendrocyte differentiation and for normal myelination (PubMed 21959935). Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis (By similarity). {ECO 0000250|UniProtKB S4R2P9, ECO 0000269|PubMed 21959935}. 
# GO_component	GO:0005741	mitochondrial outer membrane; ISS:UniProtKB.
# GO_component	GO:0005789	endoplasmic reticulum membrane; ISS:UniProtKB.
# GO_component	GO:0005874	microtubule; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; ISS:UniProtKB.
# GO_component	GO:0016528	sarcoplasm; IEA:UniProtKB-SubCell.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-SubCell.
# GO_component	GO:0031226	intrinsic component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0031594	neuromuscular junction; ISS:UniProtKB.
# GO_component	GO:0042383	sarcolemma; ISS:UniProtKB.
# GO_component	GO:0043197	dendritic spine; IEA:UniProtKB-SubCell.
# GO_component	GO:0043204	perikaryon; IEA:UniProtKB-SubCell.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IDA:UniProtKB.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_function	NAC3_HUMAN	GO 0005432 calcium sodium antiporter activity; ISS UniProtKB.
# GO_process	GO:0002244	hematopoietic progenitor cell differentiation; IEA:Ensembl.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006851	mitochondrial calcium ion transport; ISS:UniProtKB.
# GO_process	GO:0006874	cellular calcium ion homeostasis; ISS:UniProtKB.
# GO_process	GO:0007154	cell communication; IEA:InterPro.
# GO_process	GO:0007612	learning; ISS:UniProtKB.
# GO_process	GO:0007613	memory; ISS:UniProtKB.
# GO_process	GO:0014819	regulation of skeletal muscle contraction; ISS:UniProtKB.
# GO_process	GO:0021537	telencephalon development; IEA:Ensembl.
# GO_process	GO:0035725	sodium ion transmembrane transport; ISS:UniProtKB.
# GO_process	GO:0042552	myelination; ISS:UniProtKB.
# GO_process	GO:0048709	oligodendrocyte differentiation; ISS:UniProtKB.
# GO_process	GO:0051560	mitochondrial calcium ion homeostasis; ISS:UniProtKB.
# GO_process	GO:0060291	long-term synaptic potentiation; ISS:UniProtKB.
# GO_process	GO:0060402	calcium ion transport into cytosol; IEA:Ensembl.
# GO_process	GO:0070588	calcium ion transmembrane transport; ISS:UniProtKB.
# GO_process	GO:0071320	cellular response to cAMP; IEA:Ensembl.
# GO_process	GO:0071456	cellular response to hypoxia; ISS:UniProtKB.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GO_process	GO:1990034	calcium ion export from cell; IEA:Ensembl.
# GO_process	GO:1990035	calcium ion import into cell; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P57103	HS
# HGNC	HGNC:11070	SLC8A3
# InterPro	IPR003644	Calx_beta
# InterPro	IPR004836	Na_Ca_Ex
# InterPro	IPR004837	NaCa_Exmemb
# InterPro	IPR032452	Na_Ca_Ex_C-exten
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00536	 Heparan sulfate/heparin binding proteins
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04974	Protein digestion and absorption
# MIM	607991	gene
# Organism	NAC3_HUMAN	Homo sapiens (Human)
# PRINTS	PR01259	NACAEXCHNGR
# Pfam	PF01699	Na_Ca_ex; 2
# Pfam	PF03160	Calx-beta; 2
# Pfam	PF16494	Na_Ca_ex_C
# Proteomes	UP000005640	Chromosome 14
# Reactome	R-HSA-418359	Reduction of cytosolic Ca++ levels
# Reactome	R-HSA-425561	Sodium/Calcium exchangers
# Reactome	R-HSA-5578775	Ion homeostasis
# RecName	NAC3_HUMAN	Sodium/calcium exchanger 3
# RefSeq	NP_001123889	NM_001130417.2. [P57103-5]
# RefSeq	NP_150287	NM_033262.4. [P57103-7]
# RefSeq	NP_489479	NM_058240.3. [P57103-6]
# RefSeq	NP_891977	NM_182932.2. [P57103-2]
# RefSeq	NP_891981	NM_182936.2. [P57103-4]
# RefSeq	NP_892114	NM_183002.2. [P57103-1]
# RefSeq	XP_016877095	XM_017021606.1. [P57103-1]
# RefSeq	XP_016877097	XM_017021608.1. [P57103-2]
# SIMILARITY	Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 2 Calx-beta domains. {ECO	0000305}.
# SMART	SM00237	Calx_beta; 2
# SUBCELLULAR LOCATION	NAC3_HUMAN	Cell membrane {ECO 0000269|PubMed 21959935}; Multi-pass membrane protein {ECO 0000305}. Perikaryon {ECO 0000250|UniProtKB P70549}. Cell projection, dendrite {ECO 0000250|UniProtKB P70549}. Cell projection, dendritic spine {ECO 0000250|UniProtKB P70549}. Cell membrane, sarcolemma {ECO 0000250|UniProtKB S4R2P9}. Cytoplasm, sarcoplasm {ECO 0000250|UniProtKB S4R2P9}. Cell junction {ECO 0000250|UniProtKB S4R2P9}. Mitochondrion outer membrane {ECO 0000250|UniProtKB S4R2P9}; Multi-pass membrane protein {ECO 0000250|UniProtKB S4R2P9}. Cytoplasm, perinuclear region {ECO 0000269|PubMed 21959935}. Endoplasmic reticulum membrane {ECO 0000305|PubMed 21959935}; Multi-pass membrane protein {ECO 0000250|UniProtKB S4R2P9}. Note=Detected at neuromuscular junctions. {ECO 0000250|UniProtKB S4R2P9}. 
# SUBUNIT	Interacts with AKAP1. {ECO:0000250|UniProtKB	S4R2P9}. 
# TCDB	2.A.19.3:the ca(2+)	cation antiporter (caca) family
# TIGRFAMs	TIGR00845	caca
# TISSUE SPECIFICITY	Isoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle. {ECO:0000269|PubMed	15777725}. 
# TopDownProteomics	P57103-2	-. [P57103-2]
# UCSC	uc001xlu	human. [P57103-1]
# eggNOG	ENOG410XPJP	LUCA
# eggNOG	KOG1306	Eukaryota
BLAST	swissprot:NAC3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NAC3_HUMAN
BioCyc	ZFISH:ENSG00000100678-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000100678-MONOMER
COXPRESdb	6547	http://coxpresdb.jp/data/gene/6547.shtml
CleanEx	HS_SLC8A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC8A3
DOI	10.1016/S0378-1119(02)00982-4	http://dx.doi.org/10.1016/S0378-1119(02)00982-4
DOI	10.1016/j.gene.2005.01.003	http://dx.doi.org/10.1016/j.gene.2005.01.003
DOI	10.1016/j.mam.2012.07.003	http://dx.doi.org/10.1016/j.mam.2012.07.003
DOI	10.1038/cdd.2011.125	http://dx.doi.org/10.1038/cdd.2011.125
DOI	10.1038/nature01348	http://dx.doi.org/10.1038/nature01348
DOI	10.1046/j.1471-4159.2003.01511.x	http://dx.doi.org/10.1046/j.1471-4159.2003.01511.x
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
EMBL	AF508982	http://www.ebi.ac.uk/ena/data/view/AF508982
EMBL	AF510501	http://www.ebi.ac.uk/ena/data/view/AF510501
EMBL	AF510502	http://www.ebi.ac.uk/ena/data/view/AF510502
EMBL	AF510503	http://www.ebi.ac.uk/ena/data/view/AF510503
EMBL	AJ304852	http://www.ebi.ac.uk/ena/data/view/AJ304852
EMBL	AJ304853	http://www.ebi.ac.uk/ena/data/view/AJ304853
EMBL	AJ745101	http://www.ebi.ac.uk/ena/data/view/AJ745101
EMBL	AJ745102	http://www.ebi.ac.uk/ena/data/view/AJ745102
EMBL	AL135747	http://www.ebi.ac.uk/ena/data/view/AL135747
EMBL	AL160191	http://www.ebi.ac.uk/ena/data/view/AL160191
EMBL	BC142969	http://www.ebi.ac.uk/ena/data/view/BC142969
EMBL	CH471061	http://www.ebi.ac.uk/ena/data/view/CH471061
EMBL	CH471061	http://www.ebi.ac.uk/ena/data/view/CH471061
EMBL	CH471061	http://www.ebi.ac.uk/ena/data/view/CH471061
EMBL	X93017	http://www.ebi.ac.uk/ena/data/view/X93017
Ensembl	ENST00000216568	http://www.ensembl.org/id/ENST00000216568
Ensembl	ENST00000356921	http://www.ensembl.org/id/ENST00000356921
Ensembl	ENST00000357887	http://www.ensembl.org/id/ENST00000357887
Ensembl	ENST00000381269	http://www.ensembl.org/id/ENST00000381269
Ensembl	ENST00000394330	http://www.ensembl.org/id/ENST00000394330
Ensembl	ENST00000494208	http://www.ensembl.org/id/ENST00000494208
Ensembl	ENST00000528359	http://www.ensembl.org/id/ENST00000528359
Ensembl	ENST00000534137	http://www.ensembl.org/id/ENST00000534137
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005741	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005741
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005874
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016528	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016528
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0031226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031226
GO_component	GO:0031594	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031594
GO_component	GO:0042383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042383
GO_component	GO:0043197	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043197
GO_component	GO:0043204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043204
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_function	GO:0005432	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005432
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0002244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002244
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006851	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006851
GO_process	GO:0006874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874
GO_process	GO:0007154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007154
GO_process	GO:0007612	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007612
GO_process	GO:0007613	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007613
GO_process	GO:0014819	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014819
GO_process	GO:0021537	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021537
GO_process	GO:0035725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035725
GO_process	GO:0042552	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042552
GO_process	GO:0048709	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048709
GO_process	GO:0051560	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051560
GO_process	GO:0060291	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060291
GO_process	GO:0060402	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060402
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:0071320	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071320
GO_process	GO:0071456	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071456
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GO_process	GO:1990034	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990034
GO_process	GO:1990035	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990035
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC8A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC8A3
GeneID	6547	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6547
GeneTree	ENSGT00730000110414	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00730000110414
HGNC	HGNC:11070	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11070
HOGENOM	HOG000266971	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000266971&db=HOGENOM6
HOVERGEN	HBG006441	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006441&db=HOVERGEN
HPA	HPA001669	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA001669
InParanoid	P57103	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P57103
InterPro	IPR003644	http://www.ebi.ac.uk/interpro/entry/IPR003644
InterPro	IPR004836	http://www.ebi.ac.uk/interpro/entry/IPR004836
InterPro	IPR004837	http://www.ebi.ac.uk/interpro/entry/IPR004837
InterPro	IPR032452	http://www.ebi.ac.uk/interpro/entry/IPR032452
Jabion	6547	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6547
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00536	http://www.genome.jp/dbget-bin/www_bget?ko00536
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6547	http://www.genome.jp/dbget-bin/www_bget?hsa:6547
KEGG_Orthology	KO:K05849	http://www.genome.jp/dbget-bin/www_bget?KO:K05849
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04974	http://www.genome.jp/kegg-bin/show_pathway?ko04974
MIM	607991	http://www.ncbi.nlm.nih.gov/omim/607991
OMA	VHTDEPE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VHTDEPE
OrthoDB	EOG091G0EC1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0EC1
PRINTS	PR01259	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01259
PSORT	swissprot:NAC3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NAC3_HUMAN
PSORT-B	swissprot:NAC3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NAC3_HUMAN
PSORT2	swissprot:NAC3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NAC3_HUMAN
Pfam	PF01699	http://pfam.xfam.org/family/PF01699
Pfam	PF03160	http://pfam.xfam.org/family/PF03160
Pfam	PF16494	http://pfam.xfam.org/family/PF16494
PharmGKB	PA315	http://www.pharmgkb.org/do/serve?objId=PA315&objCls=Gene
Phobius	swissprot:NAC3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NAC3_HUMAN
PhylomeDB	P57103	http://phylomedb.org/?seqid=P57103
ProteinModelPortal	P57103	http://www.proteinmodelportal.org/query/uniprot/P57103
PubMed	12406570	http://www.ncbi.nlm.nih.gov/pubmed/12406570
PubMed	12508121	http://www.ncbi.nlm.nih.gov/pubmed/12508121
PubMed	12558991	http://www.ncbi.nlm.nih.gov/pubmed/12558991
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15777725	http://www.ncbi.nlm.nih.gov/pubmed/15777725
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	21959935	http://www.ncbi.nlm.nih.gov/pubmed/21959935
PubMed	23506867	http://www.ncbi.nlm.nih.gov/pubmed/23506867
Reactome	R-HSA-418359	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418359
Reactome	R-HSA-425561	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425561
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
RefSeq	NP_001123889	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001123889
RefSeq	NP_150287	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_150287
RefSeq	NP_489479	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_489479
RefSeq	NP_891977	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_891977
RefSeq	NP_891981	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_891981
RefSeq	NP_892114	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_892114
RefSeq	XP_016877095	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016877095
RefSeq	XP_016877097	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016877097
SMART	SM00237	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00237
SMR	P57103	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P57103
STRING	9606.ENSP00000370669	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000370669&targetmode=cogs
TCDB	2.A.19.3	http://www.tcdb.org/search/result.php?tc=2.A.19.3
TIGRFAMs	TIGR00845	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00845
UCSC	uc001xlu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001xlu&org=rat
UniGene	Hs.337696	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.337696
UniProtKB	NAC3_HUMAN	http://www.uniprot.org/uniprot/NAC3_HUMAN
UniProtKB-AC	P57103	http://www.uniprot.org/uniprot/P57103
charge	swissprot:NAC3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NAC3_HUMAN
eggNOG	ENOG410XPJP	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPJP
eggNOG	KOG1306	http://eggnogapi.embl.de/nog_data/html/tree/KOG1306
epestfind	swissprot:NAC3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NAC3_HUMAN
garnier	swissprot:NAC3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NAC3_HUMAN
helixturnhelix	swissprot:NAC3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NAC3_HUMAN
hmoment	swissprot:NAC3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NAC3_HUMAN
iep	swissprot:NAC3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NAC3_HUMAN
inforesidue	swissprot:NAC3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NAC3_HUMAN
neXtProt	NX_P57103	http://www.nextprot.org/db/entry/NX_P57103
octanol	swissprot:NAC3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NAC3_HUMAN
pepcoil	swissprot:NAC3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NAC3_HUMAN
pepdigest	swissprot:NAC3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NAC3_HUMAN
pepinfo	swissprot:NAC3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NAC3_HUMAN
pepnet	swissprot:NAC3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NAC3_HUMAN
pepstats	swissprot:NAC3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NAC3_HUMAN
pepwheel	swissprot:NAC3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NAC3_HUMAN
pepwindow	swissprot:NAC3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NAC3_HUMAN
sigcleave	swissprot:NAC3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NAC3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ANO8_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9HCE9-1; Sequence=Displayed; Name=2; IsoId=Q9HCE9-2; Sequence=VSP_020351, VSP_020352; 
# AltName	ANO8_HUMAN	Transmembrane protein 16H
# CCDS	CCDS32949	-. [Q9HCE9-1]
# ChiTaRS	ANO8	human
# Ensembl	ENST00000159087	ENSP00000159087; ENSG00000074855. [Q9HCE9-1]
# ExpressionAtlas	Q9HCE9	baseline and differential
# FUNCTION	ANO8_HUMAN	Does not exhibit calcium-activated chloride channel (CaCC) activity. 
# GO_component	GO:0005622	intracellular; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005229	intracellular calcium activated chloride channel activity; IMP:UniProtKB.
# GO_process	GO:0006821	chloride transport; IMP:UniProtKB.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005622	intracellular
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9HCE9	HS
# HGNC	HGNC:29329	ANO8
# InterPro	IPR007632	Anoctamin
# InterPro	IPR031289	Anoctamin-8
# MIM	610216	gene
# MISCELLANEOUS	ANO8_HUMAN	The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology. 
# Organism	ANO8_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12308	PTHR12308; 2
# PANTHER	PTHR12308:SF33	PTHR12308:SF33; 2
# Pfam	PF04547	Anoctamin
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	ANO8_HUMAN	Anoctamin-8
# RefSeq	NP_066010	NM_020959.2. [Q9HCE9-1]
# RefSeq	XP_016882537	XM_017027048.1. [Q9HCE9-2]
# SEQUENCE CAUTION	Sequence=BAB13449.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the anoctamin family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	ANO8_HUMAN	Cell membrane {ECO 0000269|PubMed 20056604, ECO 0000269|PubMed 22946059}; Multi-pass membrane protein {ECO 0000269|PubMed 20056604, ECO 0000269|PubMed 22946059}. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane. 
# TISSUE SPECIFICITY	Expressed in embryonic stem cells, fetal brain and neural tissues. {ECO:0000269|PubMed	15647853}. 
# UCSC	uc002ngf	human. [Q9HCE9-1]
# eggNOG	ENOG410XPYE	LUCA
# eggNOG	KOG2513	Eukaryota
BLAST	swissprot:ANO8_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ANO8_HUMAN
BioCyc	ZFISH:ENSG00000074855-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000074855-MONOMER
COXPRESdb	57719	http://coxpresdb.jp/data/gene/57719.shtml
CleanEx	HS_ANO8	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ANO8
DOI	10.1007/s00424-011-0975-9	http://dx.doi.org/10.1007/s00424-011-0975-9
DOI	10.1016/j.cell.2015.05.028	http://dx.doi.org/10.1016/j.cell.2015.05.028
DOI	10.1038/aps.2011.48	http://dx.doi.org/10.1038/aps.2011.48
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1074/jbc.M109.065367	http://dx.doi.org/10.1074/jbc.M109.065367
DOI	10.1093/dnares/7.4.271	http://dx.doi.org/10.1093/dnares/7.4.271
DOI	10.1093/dnares/9.3.99	http://dx.doi.org/10.1093/dnares/9.3.99
DOI	10.1113/expphysiol.2011.058198	http://dx.doi.org/10.1113/expphysiol.2011.058198
DOI	10.1113/expphysiol.2011.058214	http://dx.doi.org/10.1113/expphysiol.2011.058214
DOI	10.1159/000335765	http://dx.doi.org/10.1159/000335765
DOI	10.1242/jcs.109553	http://dx.doi.org/10.1242/jcs.109553
EMBL	AB046843	http://www.ebi.ac.uk/ena/data/view/AB046843
EMBL	AC010463	http://www.ebi.ac.uk/ena/data/view/AC010463
EMBL	CH471106	http://www.ebi.ac.uk/ena/data/view/CH471106
Ensembl	ENST00000159087	http://www.ensembl.org/id/ENST00000159087
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005229	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005229
GO_process	GO:0006821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006821
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ANO8	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ANO8
GeneID	57719	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57719
GeneTree	ENSGT00760000119015	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119015
HGNC	HGNC:29329	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:29329
HOGENOM	HOG000033952	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000033952&db=HOGENOM6
HOVERGEN	HBG100443	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG100443&db=HOVERGEN
HPA	HPA031787	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA031787
HPA	HPA049206	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA049206
InParanoid	Q9HCE9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9HCE9
IntAct	Q9HCE9	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9HCE9*
InterPro	IPR007632	http://www.ebi.ac.uk/interpro/entry/IPR007632
InterPro	IPR031289	http://www.ebi.ac.uk/interpro/entry/IPR031289
Jabion	57719	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=57719
KEGG_Gene	hsa:57719	http://www.genome.jp/dbget-bin/www_bget?hsa:57719
MIM	610216	http://www.ncbi.nlm.nih.gov/omim/610216
OMA	ACVFLLM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ACVFLLM
OrthoDB	EOG091G06A3	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G06A3
PANTHER	PTHR12308	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12308
PANTHER	PTHR12308:SF33	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12308:SF33
PSORT	swissprot:ANO8_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ANO8_HUMAN
PSORT-B	swissprot:ANO8_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ANO8_HUMAN
PSORT2	swissprot:ANO8_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ANO8_HUMAN
Pfam	PF04547	http://pfam.xfam.org/family/PF04547
PharmGKB	PA164715790	http://www.pharmgkb.org/do/serve?objId=PA164715790&objCls=Gene
Phobius	swissprot:ANO8_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ANO8_HUMAN
PhylomeDB	Q9HCE9	http://phylomedb.org/?seqid=Q9HCE9
ProteinModelPortal	Q9HCE9	http://www.proteinmodelportal.org/query/uniprot/Q9HCE9
PubMed	10997877	http://www.ncbi.nlm.nih.gov/pubmed/10997877
PubMed	12168954	http://www.ncbi.nlm.nih.gov/pubmed/12168954
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	15647853	http://www.ncbi.nlm.nih.gov/pubmed/15647853
PubMed	20056604	http://www.ncbi.nlm.nih.gov/pubmed/20056604
PubMed	21607626	http://www.ncbi.nlm.nih.gov/pubmed/21607626
PubMed	21642943	http://www.ncbi.nlm.nih.gov/pubmed/21642943
PubMed	21984732	http://www.ncbi.nlm.nih.gov/pubmed/21984732
PubMed	22178883	http://www.ncbi.nlm.nih.gov/pubmed/22178883
PubMed	22302790	http://www.ncbi.nlm.nih.gov/pubmed/22302790
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	22946059	http://www.ncbi.nlm.nih.gov/pubmed/22946059
PubMed	26091039	http://www.ncbi.nlm.nih.gov/pubmed/26091039
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_066010	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_066010
RefSeq	XP_016882537	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016882537
STRING	9606.ENSP00000159087	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000159087&targetmode=cogs
UCSC	uc002ngf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ngf&org=rat
UniGene	Hs.590990	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.590990
UniProtKB	ANO8_HUMAN	http://www.uniprot.org/uniprot/ANO8_HUMAN
UniProtKB-AC	Q9HCE9	http://www.uniprot.org/uniprot/Q9HCE9
charge	swissprot:ANO8_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ANO8_HUMAN
eggNOG	ENOG410XPYE	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPYE
eggNOG	KOG2513	http://eggnogapi.embl.de/nog_data/html/tree/KOG2513
epestfind	swissprot:ANO8_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ANO8_HUMAN
garnier	swissprot:ANO8_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ANO8_HUMAN
helixturnhelix	swissprot:ANO8_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ANO8_HUMAN
hmoment	swissprot:ANO8_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ANO8_HUMAN
iep	swissprot:ANO8_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ANO8_HUMAN
inforesidue	swissprot:ANO8_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ANO8_HUMAN
neXtProt	NX_Q9HCE9	http://www.nextprot.org/db/entry/NX_Q9HCE9
octanol	swissprot:ANO8_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ANO8_HUMAN
pepcoil	swissprot:ANO8_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ANO8_HUMAN
pepdigest	swissprot:ANO8_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ANO8_HUMAN
pepinfo	swissprot:ANO8_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ANO8_HUMAN
pepnet	swissprot:ANO8_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ANO8_HUMAN
pepstats	swissprot:ANO8_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ANO8_HUMAN
pepwheel	swissprot:ANO8_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ANO8_HUMAN
pepwindow	swissprot:ANO8_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ANO8_HUMAN
sigcleave	swissprot:ANO8_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ANO8_HUMAN
## Database	ID	URL or Descriptions
# AltName	MOT10_HUMAN	Aromatic amino acid transporter 1
# AltName	MOT10_HUMAN	Solute carrier family 16 member 10
# AltName	MOT10_HUMAN	T-type amino acid transporter 1
# BioGrid	125582	13
# CDD	cd06174	MFS
# DrugBank	DB00117	L-Histidine
# DrugBank	DB00119	Pyruvic acid
# DrugBank	DB00120	L-Phenylalanine
# DrugBank	DB00123	L-Lysine
# DrugBank	DB00125	L-Arginine
# DrugBank	DB00128	L-Aspartic Acid
# DrugBank	DB00130	L-Glutamine
# DrugBank	DB00133	L-Serine
# DrugBank	DB00134	L-Methionine
# DrugBank	DB00135	L-Tyrosine
# DrugBank	DB00138	L-Cystine
# DrugBank	DB00145	Glycine
# DrugBank	DB00149	L-Leucine
# DrugBank	DB00150	L-Tryptophan
# DrugBank	DB00151	L-Cysteine
# DrugBank	DB00156	L-Threonine
# DrugBank	DB00160	L-Alanine
# DrugBank	DB00161	L-Valine
# DrugBank	DB00167	L-Isoleucine
# DrugBank	DB00172	L-Proline
# DrugBank	DB00174	L-Asparagine
# DrugBank	DB00279	Liothyronine
# DrugBank	DB01235	Levodopa
# DrugBank	DB01583	Liotrix
# DrugBank	DB04398	Lactic Acid
# DrugBank	DB06262	Droxidopa
# Ensembl	ENST00000368851	ENSP00000357844; ENSG00000112394
# ExpressionAtlas	Q8TF71	baseline and differential
# FUNCTION	MOT10_HUMAN	Sodium-independent transporter that mediates the uptake of aromatic acids. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity). {ECO 0000250, ECO 0000269|PubMed 11827462}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IEA:InterPro.
# GO_component	GO:0016021	integral component of membrane; IBA:GO_Central.
# GO_component	GO:0016323	basolateral plasma membrane; TAS:HGNC.
# GO_function	GO:0005215	transporter activity; IBA:GO_Central.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015173	aromatic amino acid transmembrane transporter activity; IEA:InterPro.
# GO_function	GO:0015349	thyroid hormone transmembrane transporter activity; IEA:InterPro.
# GO_process	GO:0006865	amino acid transport; TAS:Reactome.
# GO_process	GO:0015801	aromatic amino acid transport; TAS:HGNC.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q8TF71	HS
# HGNC	HGNC:17027	SLC16A10
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# InterPro	IPR030762	MCT10
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04974	Protein digestion and absorption
# MIM	607550	gene
# Organism	MOT10_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11360:SF119	PTHR11360:SF119
# PROSITE	PS50850	MFS
# PTM	MOT10_HUMAN	Not N-glycosylated. {ECO 0000250}. 
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-352230	Amino acid transport across the plasma membrane
# RecName	MOT10_HUMAN	Monocarboxylate transporter 10
# RefSeq	NP_061063	NM_018593.4
# SEQUENCE CAUTION	Sequence=AAH17968.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	MOT10_HUMAN	Cell membrane {ECO 0000269|PubMed 11827462}; Multi-pass membrane protein {ECO 0000255}. Basolateral cell membrane {ECO 0000250}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.13	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	Strongly expressed in kidney and skeletal muscle and at lower level in placenta and heart. {ECO:0000269|PubMed	11827462}. 
# UCSC	uc003pus	human
# eggNOG	COG0477	LUCA
# eggNOG	KOG2504	Eukaryota
BLAST	swissprot:MOT10_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MOT10_HUMAN
BioCyc	ZFISH:ENSG00000112394-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000112394-MONOMER
COXPRESdb	117247	http://coxpresdb.jp/data/gene/117247.shtml
CleanEx	HS_SLC16A10	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC16A10
DOI	10.1006/geno.2001.6678	http://dx.doi.org/10.1006/geno.2001.6678
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DrugBank	DB00117	http://www.drugbank.ca/drugs/DB00117
DrugBank	DB00119	http://www.drugbank.ca/drugs/DB00119
DrugBank	DB00120	http://www.drugbank.ca/drugs/DB00120
DrugBank	DB00123	http://www.drugbank.ca/drugs/DB00123
DrugBank	DB00125	http://www.drugbank.ca/drugs/DB00125
DrugBank	DB00128	http://www.drugbank.ca/drugs/DB00128
DrugBank	DB00130	http://www.drugbank.ca/drugs/DB00130
DrugBank	DB00133	http://www.drugbank.ca/drugs/DB00133
DrugBank	DB00134	http://www.drugbank.ca/drugs/DB00134
DrugBank	DB00135	http://www.drugbank.ca/drugs/DB00135
DrugBank	DB00138	http://www.drugbank.ca/drugs/DB00138
DrugBank	DB00145	http://www.drugbank.ca/drugs/DB00145
DrugBank	DB00149	http://www.drugbank.ca/drugs/DB00149
DrugBank	DB00150	http://www.drugbank.ca/drugs/DB00150
DrugBank	DB00151	http://www.drugbank.ca/drugs/DB00151
DrugBank	DB00156	http://www.drugbank.ca/drugs/DB00156
DrugBank	DB00160	http://www.drugbank.ca/drugs/DB00160
DrugBank	DB00161	http://www.drugbank.ca/drugs/DB00161
DrugBank	DB00167	http://www.drugbank.ca/drugs/DB00167
DrugBank	DB00172	http://www.drugbank.ca/drugs/DB00172
DrugBank	DB00174	http://www.drugbank.ca/drugs/DB00174
DrugBank	DB00279	http://www.drugbank.ca/drugs/DB00279
DrugBank	DB01235	http://www.drugbank.ca/drugs/DB01235
DrugBank	DB01583	http://www.drugbank.ca/drugs/DB01583
DrugBank	DB04398	http://www.drugbank.ca/drugs/DB04398
DrugBank	DB06262	http://www.drugbank.ca/drugs/DB06262
EMBL	AB057445	http://www.ebi.ac.uk/ena/data/view/AB057445
EMBL	AK126183	http://www.ebi.ac.uk/ena/data/view/AK126183
EMBL	AK172789	http://www.ebi.ac.uk/ena/data/view/AK172789
EMBL	AL360227	http://www.ebi.ac.uk/ena/data/view/AL360227
EMBL	BC017968	http://www.ebi.ac.uk/ena/data/view/BC017968
EMBL	BC066985	http://www.ebi.ac.uk/ena/data/view/BC066985
EMBL	CH471051	http://www.ebi.ac.uk/ena/data/view/CH471051
Ensembl	ENST00000368851	http://www.ensembl.org/id/ENST00000368851
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_function	GO:0015173	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015173
GO_function	GO:0015349	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015349
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GO_process	GO:0015801	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015801
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC16A10	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC16A10
GeneID	117247	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=117247
GeneTree	ENSGT00740000115479	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00740000115479
HGNC	HGNC:17027	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17027
HOGENOM	HOG000046644	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000046644&db=HOGENOM6
HOVERGEN	HBG006387	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006387&db=HOVERGEN
HPA	HPA016860	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA016860
InParanoid	Q8TF71	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8TF71
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
InterPro	IPR030762	http://www.ebi.ac.uk/interpro/entry/IPR030762
Jabion	117247	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=117247
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:117247	http://www.genome.jp/dbget-bin/www_bget?hsa:117247
KEGG_Orthology	KO:K08187	http://www.genome.jp/dbget-bin/www_bget?KO:K08187
KEGG_Pathway	ko04974	http://www.genome.jp/kegg-bin/show_pathway?ko04974
MIM	607550	http://www.ncbi.nlm.nih.gov/omim/607550
OMA	HLMKHVN	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HLMKHVN
OrthoDB	EOG091G0449	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0449
PANTHER	PTHR11360:SF119	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11360:SF119
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:MOT10_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MOT10_HUMAN
PSORT-B	swissprot:MOT10_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MOT10_HUMAN
PSORT2	swissprot:MOT10_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MOT10_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA38197	http://www.pharmgkb.org/do/serve?objId=PA38197&objCls=Gene
Phobius	swissprot:MOT10_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MOT10_HUMAN
PhylomeDB	Q8TF71	http://phylomedb.org/?seqid=Q8TF71
ProteinModelPortal	Q8TF71	http://www.proteinmodelportal.org/query/uniprot/Q8TF71
PubMed	11827462	http://www.ncbi.nlm.nih.gov/pubmed/11827462
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
Reactome	R-HSA-352230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-352230
RefSeq	NP_061063	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061063
STRING	9606.ENSP00000357844	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000357844&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.13	http://www.tcdb.org/search/result.php?tc=2.A.1.13
UCSC	uc003pus	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003pus&org=rat
UniGene	Hs.591327	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.591327
UniProtKB	MOT10_HUMAN	http://www.uniprot.org/uniprot/MOT10_HUMAN
UniProtKB-AC	Q8TF71	http://www.uniprot.org/uniprot/Q8TF71
charge	swissprot:MOT10_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MOT10_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG2504	http://eggnogapi.embl.de/nog_data/html/tree/KOG2504
epestfind	swissprot:MOT10_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MOT10_HUMAN
garnier	swissprot:MOT10_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MOT10_HUMAN
helixturnhelix	swissprot:MOT10_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MOT10_HUMAN
hmoment	swissprot:MOT10_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MOT10_HUMAN
iep	swissprot:MOT10_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MOT10_HUMAN
inforesidue	swissprot:MOT10_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MOT10_HUMAN
neXtProt	NX_Q8TF71	http://www.nextprot.org/db/entry/NX_Q8TF71
octanol	swissprot:MOT10_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MOT10_HUMAN
pepcoil	swissprot:MOT10_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MOT10_HUMAN
pepdigest	swissprot:MOT10_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MOT10_HUMAN
pepinfo	swissprot:MOT10_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MOT10_HUMAN
pepnet	swissprot:MOT10_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MOT10_HUMAN
pepstats	swissprot:MOT10_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MOT10_HUMAN
pepwheel	swissprot:MOT10_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MOT10_HUMAN
pepwindow	swissprot:MOT10_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MOT10_HUMAN
sigcleave	swissprot:MOT10_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MOT10_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	VATG3_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q96LB4-1; Sequence=Displayed; Name=2; IsoId=Q96LB4-2; Sequence=Not described; Name=3; IsoId=Q96LB4-3; Sequence=VSP_036423; Name=4; IsoId=Q96LB4-4; Sequence=VSP_036426; Note=No experimental confirmation available.; 
# AltName	VATG3_HUMAN	V-ATPase 13 kDa subunit 3
# AltName	VATG3_HUMAN	Vacuolar proton pump subunit G 3
# CCDS	CCDS1395	-. [Q96LB4-1]
# CCDS	CCDS1396	-. [Q96LB4-3]
# CCDS	CCDS81414	-. [Q96LB4-4]
# Ensembl	ENST00000281087	ENSP00000281087; ENSG00000151418. [Q96LB4-1]
# Ensembl	ENST00000309309	ENSP00000309574; ENSG00000151418. [Q96LB4-3]
# Ensembl	ENST00000367381	ENSP00000356351; ENSG00000263014. [Q96LB4-1]
# Ensembl	ENST00000367382	ENSP00000356352; ENSG00000151418. [Q96LB4-1]
# Ensembl	ENST00000489986	ENSP00000417171; ENSG00000151418. [Q96LB4-4]
# Ensembl	ENST00000571439	ENSP00000461616; ENSG00000263014. [Q96LB4-3]
# Ensembl	ENST00000573121	ENSP00000461329; ENSG00000263014. [Q96LB4-1]
# Ensembl	ENST00000575971	ENSP00000461228; ENSG00000263014. [Q96LB4-4]
# FUNCTION	VATG3_HUMAN	Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. 
# GO_component	GO:0005829	cytosol; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016471	vacuolar proton-transporting V-type ATPase complex; IEA:InterPro.
# GO_function	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism; IEA:Ensembl.
# GO_function	GO:0051117	ATPase binding; IPI:UniProtKB.
# GO_process	GO:0008286	insulin receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0033572	transferrin transport; TAS:Reactome.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0090383	phagosome acidification; TAS:Reactome.
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q96LB4	HS
# HGNC	HGNC:18265	ATP6V1G3
# InterPro	IPR005124	V-ATPase_G
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04966	Collecting duct acid secretion
# KEGG_Pathway	ko05110	Vibrio cholerae infection
# KEGG_Pathway	ko05120	Epithelial cell signaling in Helicobacter pylori infection
# KEGG_Pathway	ko05323	Rheumatoid arthritis
# Organism	VATG3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12713	PTHR12713
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-1222556	ROS, RNS production in response to bacteria
# Reactome	R-HSA-77387	Insulin receptor recycling
# Reactome	R-HSA-917977	Transferrin endocytosis and recycling
# Reactome	R-HSA-983712	Ion channel transport
# RecName	VATG3_HUMAN	V-type proton ATPase subunit G 3
# RefSeq	NP_001307147	NM_001320218.1. [Q96LB4-4]
# RefSeq	NP_573569	NM_133262.2. [Q96LB4-1]
# RefSeq	NP_579872	NM_133326.1. [Q96LB4-3]
# RefSeq	XP_006711226	XM_006711163.3. [Q96LB4-1]
# RefSeq	XP_011507488	XM_011509186.2. [Q96LB4-4]
# RefSeq	XP_011507489	XM_011509187.2. [Q96LB4-3]
# SIMILARITY	Belongs to the V-ATPase G subunit family. {ECO	0000305}.
# SUBUNIT	V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d). {ECO	0000250}. 
# TCDB	3.A.2.2	the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily
# TIGRFAMs	TIGR01147	V_ATP_synt_G
# TISSUE SPECIFICITY	Kidney. {ECO:0000269|PubMed	12384298}. 
# UCSC	uc001guo	human. [Q96LB4-1]
# eggNOG	ENOG4111XX0	LUCA
# eggNOG	KOG1772	Eukaryota
BLAST	swissprot:VATG3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VATG3_HUMAN
BioCyc	MetaCyc:HS07734-MONOMER	http://biocyc.org/getid?id=MetaCyc:HS07734-MONOMER
BioCyc	ZFISH:HS07734-MONOMER	http://biocyc.org/getid?id=ZFISH:HS07734-MONOMER
COXPRESdb	127124	http://coxpresdb.jp/data/gene/127124.shtml
CleanEx	HS_ATP6V1G3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP6V1G3
DOI	10.1016/S0378-1119(02)00884-3	http://dx.doi.org/10.1016/S0378-1119(02)00884-3
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AL157402	http://www.ebi.ac.uk/ena/data/view/AL157402
EMBL	AY039760	http://www.ebi.ac.uk/ena/data/view/AY039760
EMBL	BC101129	http://www.ebi.ac.uk/ena/data/view/BC101129
EMBL	BC101130	http://www.ebi.ac.uk/ena/data/view/BC101130
EMBL	BC101131	http://www.ebi.ac.uk/ena/data/view/BC101131
Ensembl	ENST00000281087	http://www.ensembl.org/id/ENST00000281087
Ensembl	ENST00000309309	http://www.ensembl.org/id/ENST00000309309
Ensembl	ENST00000367381	http://www.ensembl.org/id/ENST00000367381
Ensembl	ENST00000367382	http://www.ensembl.org/id/ENST00000367382
Ensembl	ENST00000489986	http://www.ensembl.org/id/ENST00000489986
Ensembl	ENST00000571439	http://www.ensembl.org/id/ENST00000571439
Ensembl	ENST00000573121	http://www.ensembl.org/id/ENST00000573121
Ensembl	ENST00000575971	http://www.ensembl.org/id/ENST00000575971
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016471
GO_function	GO:0008553	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008553
GO_function	GO:0051117	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051117
GO_process	GO:0008286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008286
GO_process	GO:0033572	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033572
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0090383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090383
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ATP6V1G3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP6V1G3
GeneID	127124	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=127124
GeneTree	ENSGT00390000011172	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000011172
HGNC	HGNC:18265	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18265
HOGENOM	HOG000186416	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000186416&db=HOGENOM6
HOVERGEN	HBG057827	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG057827&db=HOVERGEN
HPA	HPA028701	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA028701
InParanoid	Q96LB4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96LB4
InterPro	IPR005124	http://www.ebi.ac.uk/interpro/entry/IPR005124
Jabion	127124	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=127124
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:127124	http://www.genome.jp/dbget-bin/www_bget?hsa:127124
KEGG_Orthology	KO:K02152	http://www.genome.jp/dbget-bin/www_bget?KO:K02152
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04966	http://www.genome.jp/kegg-bin/show_pathway?ko04966
KEGG_Pathway	ko05110	http://www.genome.jp/kegg-bin/show_pathway?ko05110
KEGG_Pathway	ko05120	http://www.genome.jp/kegg-bin/show_pathway?ko05120
KEGG_Pathway	ko05323	http://www.genome.jp/kegg-bin/show_pathway?ko05323
OMA	YNKYMES	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YNKYMES
OrthoDB	EOG091G0XIZ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0XIZ
PANTHER	PTHR12713	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12713
PSORT	swissprot:VATG3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VATG3_HUMAN
PSORT-B	swissprot:VATG3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VATG3_HUMAN
PSORT2	swissprot:VATG3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VATG3_HUMAN
PharmGKB	PA38515	http://www.pharmgkb.org/do/serve?objId=PA38515&objCls=Gene
Phobius	swissprot:VATG3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VATG3_HUMAN
PhylomeDB	Q96LB4	http://phylomedb.org/?seqid=Q96LB4
ProteinModelPortal	Q96LB4	http://www.proteinmodelportal.org/query/uniprot/Q96LB4
PubMed	12384298	http://www.ncbi.nlm.nih.gov/pubmed/12384298
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
Reactome	R-HSA-1222556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1222556
Reactome	R-HSA-77387	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-77387
Reactome	R-HSA-917977	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917977
Reactome	R-HSA-983712	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983712
RefSeq	NP_001307147	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001307147
RefSeq	NP_573569	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_573569
RefSeq	NP_579872	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_579872
RefSeq	XP_006711226	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006711226
RefSeq	XP_011507488	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011507488
RefSeq	XP_011507489	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011507489
SMR	Q96LB4	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q96LB4
STRING	9606.ENSP00000281087	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000281087&targetmode=cogs
TCDB	3.A.2.2	http://www.tcdb.org/search/result.php?tc=3.A.2.2
TIGRFAMs	TIGR01147	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01147
UCSC	uc001guo	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001guo&org=rat
UniGene	Hs.127743	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.127743
UniProtKB	VATG3_HUMAN	http://www.uniprot.org/uniprot/VATG3_HUMAN
UniProtKB-AC	Q96LB4	http://www.uniprot.org/uniprot/Q96LB4
charge	swissprot:VATG3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VATG3_HUMAN
eggNOG	ENOG4111XX0	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111XX0
eggNOG	KOG1772	http://eggnogapi.embl.de/nog_data/html/tree/KOG1772
epestfind	swissprot:VATG3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VATG3_HUMAN
garnier	swissprot:VATG3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VATG3_HUMAN
helixturnhelix	swissprot:VATG3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VATG3_HUMAN
hmoment	swissprot:VATG3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VATG3_HUMAN
iep	swissprot:VATG3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VATG3_HUMAN
inforesidue	swissprot:VATG3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VATG3_HUMAN
neXtProt	NX_Q96LB4	http://www.nextprot.org/db/entry/NX_Q96LB4
octanol	swissprot:VATG3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VATG3_HUMAN
pepcoil	swissprot:VATG3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VATG3_HUMAN
pepdigest	swissprot:VATG3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VATG3_HUMAN
pepinfo	swissprot:VATG3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VATG3_HUMAN
pepnet	swissprot:VATG3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VATG3_HUMAN
pepstats	swissprot:VATG3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VATG3_HUMAN
pepwheel	swissprot:VATG3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VATG3_HUMAN
pepwindow	swissprot:VATG3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VATG3_HUMAN
sigcleave	swissprot:VATG3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VATG3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	NOX5_HUMAN	Event=Alternative splicing; Named isoforms=6; Name=v3; Synonyms=NOX5gamma; IsoId=Q96PH1-1; Sequence=Displayed; Name=v1; Synonyms=NOX5alpha; IsoId=Q96PH1-3; Sequence=VSP_017328; Name=v2; Synonyms=NOX5beta; IsoId=Q96PH1-4; Sequence=VSP_017327, VSP_017328; Name=v4; Synonyms=NOX5delta; IsoId=Q96PH1-2; Sequence=VSP_017327; Name=v5; Synonyms=NOX5epsilon, NOX5S; IsoId=Q96PH1-5; Sequence=VSP_017326; Name=v6; Synonyms=NOX5zeta; IsoId=Q96PH1-6; Sequence=VSP_041619, VSP_017328; Note=No experimental confirmation available.; 
# BIOPHYSICOCHEMICAL PROPERTIES	Kinetic parameters: KM=1.06 uM for calcium {ECO	0000269|PubMed:14982937}; 
# BioGrid	122660	12
# CCDS	CCDS32276	-. [Q96PH1-1]
# CCDS	CCDS53953	-. [Q96PH1-6]
# CCDS	CCDS53954	-. [Q96PH1-3]
# CDD	cd00051	EFh; 2
# COFACTOR	NOX5_HUMAN	Name=FAD; Xref=ChEBI CHEBI 57692; Evidence={ECO 0000269|PubMed 14982937}; 
# COFACTOR	NOX5_HUMAN	Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 14982937}; 
# DEVELOPMENTAL STAGE	Expressed in fetal tissues. {ECO:0000269|PubMed	11376945}. 
# DOMAIN	NOX5_HUMAN	Isoform v1 and isoform v2 of this protein have four functional EF-hand calcium-binding domains. Isoform v3 and isoform v4 have the third EF-hand domain interrupted by an insert. 
# ENZYME REGULATION	Activated by calcium which induces conformational changes and interaction between the N-terminal regulatory region and the C-terminal catalytic region. Inhibited by diphenylene iodonium. {ECO:0000269|PubMed	14982937}. 
# Ensembl	ENST00000260364	ENSP00000454143; ENSG00000255346. [Q96PH1-2]
# Ensembl	ENST00000388866	ENSP00000373518; ENSG00000255346. [Q96PH1-1]
# Ensembl	ENST00000448182	ENSP00000410887; ENSG00000255346. [Q96PH1-4]
# Ensembl	ENST00000455873	ENSP00000416828; ENSG00000255346. [Q96PH1-6]
# Ensembl	ENST00000530406	ENSP00000432440; ENSG00000255346. [Q96PH1-3]
# ExpressionAtlas	Q96PH1	baseline and differential
# FUNCTION	NOX5_HUMAN	Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis. Isoform v2 and isoform v5 are involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin. {ECO 0000269|PubMed 11483596, ECO 0000269|PubMed 12686516, ECO 0000269|PubMed 17275676}. 
# GO_component	GO:0005783	endoplasmic reticulum; IDA:UniProtKB.
# GO_component	GO:0005789	endoplasmic reticulum membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005509	calcium ion binding; IEA:InterPro.
# GO_function	GO:0015252	hydrogen ion channel activity; IDA:UniProtKB.
# GO_function	GO:0016175	superoxide-generating NADPH oxidase activity; IDA:UniProtKB.
# GO_function	GO:0020037	heme binding; NAS:UniProtKB.
# GO_function	GO:0050660	flavin adenine dinucleotide binding; NAS:UniProtKB.
# GO_function	GO:0050661	NADP binding; NAS:UniProtKB.
# GO_process	GO:0000302	response to reactive oxygen species; TAS:Reactome.
# GO_process	GO:0000910	cytokinesis; NAS:UniProtKB.
# GO_process	GO:0001525	angiogenesis; IDA:UniProtKB.
# GO_process	GO:0001935	endothelial cell proliferation; IDA:UniProtKB.
# GO_process	GO:0006915	apoptotic process; NAS:UniProtKB.
# GO_process	GO:0008283	cell proliferation; NAS:UniProtKB.
# GO_process	GO:0010155	regulation of proton transport; NAS:UniProtKB.
# GO_process	GO:0042554	superoxide anion generation; IDA:UniProtKB.
# GO_process	GO:0043012	regulation of fusion of sperm to egg plasma membrane; NAS:UniProtKB.
# GO_process	GO:0050663	cytokine secretion; NAS:UniProtKB.
# GO_process	GO:0055114	oxidation-reduction process; IDA:UniProtKB.
# GO_process	GO:2000379	positive regulation of reactive oxygen species metabolic process; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0008219	cell death
# GOslim_process	GO:0008283	cell proliferation
# GOslim_process	GO:0048646	anatomical structure formation involved in morphogenesis
# Gene3D	1.10.238.10	-; 1.
# Genevisible	Q96PH1	HS
# HGNC	HGNC:14874	NOX5
# INDUCTION	Down-regulated by TGFB1. {ECO:0000269|PubMed	16179589}. 
# INTERACTION	NOX5_HUMAN	P62157 CALM (xeno); NbExp=3; IntAct=EBI-7305642, EBI-397403; 
# InterPro	IPR002048	EF_hand_dom
# InterPro	IPR011992	EF-hand-dom_pair
# InterPro	IPR013112	FAD-bd_8
# InterPro	IPR013121	Fe_red_NAD-bd_6
# InterPro	IPR013130	Fe3_Rdtase_TM_dom
# InterPro	IPR017927	Fd_Rdtase_FAD-bd
# InterPro	IPR017938	Riboflavin_synthase-like_b-brl
# InterPro	IPR018247	EF_Hand_1_Ca_BS
# InterPro	IPR029648	NOX5
# MIM	606572	gene
# Organism	NOX5_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11972:SF58	PTHR11972:SF58; 3
# PROSITE	PS00018	EF_HAND_1; 2
# PROSITE	PS50222	EF_HAND_2; 3
# PROSITE	PS51384	FAD_FR
# PeroxiBase	6024	HsNOx05
# Pfam	PF01794	Ferric_reduct
# Pfam	PF08022	FAD_binding_8
# Pfam	PF08030	NAD_binding_6
# Pfam	PF13202	EF-hand_5
# Pfam	PF13405	EF-hand_6
# Proteomes	UP000005640	Chromosome 15
# Reactome	R-HSA-3299685	Detoxification of Reactive Oxygen Species
# RecName	NOX5_HUMAN	NADPH oxidase 5
# RefSeq	NP_001171708	NM_001184779.1. [Q96PH1-3]
# RefSeq	NP_001171709	NM_001184780.1. [Q96PH1-6]
# RefSeq	NP_078781	NM_024505.3. [Q96PH1-1]
# SEQUENCE CAUTION	Sequence=AAG33638.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15319.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305}; Sequence=BAB84897.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
# SIMILARITY	Contains 1 FAD-binding FR-type domain. {ECO:0000255|PROSITE-ProRule	PRU00716}. 
# SIMILARITY	Contains 1 ferric oxidoreductase domain. {ECO	0000305}. 
# SIMILARITY	Contains 4 EF-hand domains. {ECO:0000255|PROSITE- ProRule	PRU00448}. 
# SMART	SM00054	EFh; 2
# SUBCELLULAR LOCATION	NOX5_HUMAN	Isoform v2  Endoplasmic reticulum. 
# SUBCELLULAR LOCATION	NOX5_HUMAN	Isoform v5  Endoplasmic reticulum. 
# SUBCELLULAR LOCATION	NOX5_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF47473	SSF47473; 2
# SUPFAM	SSF63380	SSF63380; 2
# TCDB	5.B.1.1	the phagocyte (gp91(phox)) nadph oxidase family
# TISSUE SPECIFICITY	NOX5_HUMAN	Mainly expressed in pachytene spermatocytes of testis and in lymphocyte-rich areas of spleen and lymph nodes. Isoform v1 is expressed in spleen. Isoform v2 is expressed in testis. Also detected in ovary, placenta, pancreas, cardiac fibroblasts. Expressed in B-cells and prostate malignant cells. Isoform v1 and isoform v3 are expressed in epithelial colorectal adenocarcinoma cells. Isoform v2 and isoform v4 are expressed in endothelial cells. Isoform v1, isoform v2, isoform v3 and isoform v4 are expressed in pulmonary artery smooth muscle cells. Isoform v2 and isoform v5 are expressed in microvascular endothelial cells (at protein level). {ECO 0000269|PubMed 11376945, ECO 0000269|PubMed 11483596, ECO 0000269|PubMed 12686516, ECO 0000269|PubMed 16179589, ECO 0000269|PubMed 16339585, ECO 0000269|PubMed 17275676}. 
# UCSC	uc002arp	human. [Q96PH1-1]
# eggNOG	ENOG410XNZY	LUCA
# eggNOG	KOG0039	Eukaryota
BLAST	swissprot:NOX5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NOX5_HUMAN
BioCyc	ZFISH:HS06400-MONOMER	http://biocyc.org/getid?id=ZFISH:HS06400-MONOMER
COXPRESdb	79400	http://coxpresdb.jp/data/gene/79400.shtml
CleanEx	HS_NOX5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_NOX5
DOI	10.1016/S0378-1119(01)00449-8	http://dx.doi.org/10.1016/S0378-1119(01)00449-8
DOI	10.1016/j.freeradbiomed.2006.10.054	http://dx.doi.org/10.1016/j.freeradbiomed.2006.10.054
DOI	10.1038/nature04601	http://dx.doi.org/10.1038/nature04601
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M103034200	http://dx.doi.org/10.1074/jbc.M103034200
DOI	10.1074/jbc.M310268200	http://dx.doi.org/10.1074/jbc.M310268200
DOI	10.1074/jbc.M501882200	http://dx.doi.org/10.1074/jbc.M501882200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1152/ajpcell.00525.2002	http://dx.doi.org/10.1152/ajpcell.00525.2002
DOI	10.1161/01.RES.0000187457.24338.3D	http://dx.doi.org/10.1161/01.RES.0000187457.24338.3D
DOI	10.4049/jimmunol.175.12.8424	http://dx.doi.org/10.4049/jimmunol.175.12.8424
EC_number	EC:1.6.3.-	http://www.genome.jp/dbget-bin/www_bget?EC:1.6.3.-
EMBL	AC027088	http://www.ebi.ac.uk/ena/data/view/AC027088
EMBL	AC087639	http://www.ebi.ac.uk/ena/data/view/AC087639
EMBL	AF317889	http://www.ebi.ac.uk/ena/data/view/AF317889
EMBL	AF325189	http://www.ebi.ac.uk/ena/data/view/AF325189
EMBL	AF325190	http://www.ebi.ac.uk/ena/data/view/AF325190
EMBL	AF353088	http://www.ebi.ac.uk/ena/data/view/AF353088
EMBL	AF353089	http://www.ebi.ac.uk/ena/data/view/AF353089
EMBL	AK026011	http://www.ebi.ac.uk/ena/data/view/AK026011
EMBL	AK074058	http://www.ebi.ac.uk/ena/data/view/AK074058
EMBL	AK074071	http://www.ebi.ac.uk/ena/data/view/AK074071
EMBL	AK314689	http://www.ebi.ac.uk/ena/data/view/AK314689
EMBL	BC125097	http://www.ebi.ac.uk/ena/data/view/BC125097
EMBL	BC125098	http://www.ebi.ac.uk/ena/data/view/BC125098
EMBL	CH471082	http://www.ebi.ac.uk/ena/data/view/CH471082
EMBL	DQ314884	http://www.ebi.ac.uk/ena/data/view/DQ314884
ENZYME	1.6.3.-	http://enzyme.expasy.org/EC/1.6.3.-
Ensembl	ENST00000260364	http://www.ensembl.org/id/ENST00000260364
Ensembl	ENST00000388866	http://www.ensembl.org/id/ENST00000388866
Ensembl	ENST00000448182	http://www.ensembl.org/id/ENST00000448182
Ensembl	ENST00000455873	http://www.ensembl.org/id/ENST00000455873
Ensembl	ENST00000530406	http://www.ensembl.org/id/ENST00000530406
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0015252	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015252
GO_function	GO:0016175	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016175
GO_function	GO:0020037	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037
GO_function	GO:0050660	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660
GO_function	GO:0050661	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050661
GO_process	GO:0000302	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000302
GO_process	GO:0000910	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000910
GO_process	GO:0001525	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001525
GO_process	GO:0001935	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001935
GO_process	GO:0006915	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006915
GO_process	GO:0008283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008283
GO_process	GO:0010155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010155
GO_process	GO:0042554	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042554
GO_process	GO:0043012	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043012
GO_process	GO:0050663	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050663
GO_process	GO:0055114	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114
GO_process	GO:2000379	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000379
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0008219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219
GOslim_process	GO:0008283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008283
GOslim_process	GO:0048646	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048646
Gene3D	1.10.238.10	http://www.cathdb.info/version/latest/superfamily/1.10.238.10
GeneCards	NOX5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=NOX5
GeneID	79400	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79400
GeneTree	ENSGT00550000074350	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074350
H-InvDB	HIX0012384	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0012384
HGNC	HGNC:14874	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14874
HOVERGEN	HBG082052	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG082052&db=HOVERGEN
HPA	HPA019362	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA019362
InParanoid	Q96PH1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96PH1
IntAct	Q96PH1	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96PH1*
IntEnz	1.6.3	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.6.3
InterPro	IPR002048	http://www.ebi.ac.uk/interpro/entry/IPR002048
InterPro	IPR011992	http://www.ebi.ac.uk/interpro/entry/IPR011992
InterPro	IPR013112	http://www.ebi.ac.uk/interpro/entry/IPR013112
InterPro	IPR013121	http://www.ebi.ac.uk/interpro/entry/IPR013121
InterPro	IPR013130	http://www.ebi.ac.uk/interpro/entry/IPR013130
InterPro	IPR017927	http://www.ebi.ac.uk/interpro/entry/IPR017927
InterPro	IPR017938	http://www.ebi.ac.uk/interpro/entry/IPR017938
InterPro	IPR018247	http://www.ebi.ac.uk/interpro/entry/IPR018247
InterPro	IPR029648	http://www.ebi.ac.uk/interpro/entry/IPR029648
Jabion	79400	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=79400
KEGG_Gene	hsa:79400	http://www.genome.jp/dbget-bin/www_bget?hsa:79400
MIM	606572	http://www.ncbi.nlm.nih.gov/omim/606572
OMA	EMSSENH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EMSSENH
OrthoDB	EOG091G019B	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G019B
PANTHER	PTHR11972:SF58	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11972:SF58
PROSITE	PS00018	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00018
PROSITE	PS50222	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50222
PROSITE	PS51384	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51384
PSORT	swissprot:NOX5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NOX5_HUMAN
PSORT-B	swissprot:NOX5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NOX5_HUMAN
PSORT2	swissprot:NOX5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NOX5_HUMAN
PeroxiBase	6024	http://peroxibase.toulouse.inra.fr/listing.php?action=view&id=6024
Pfam	PF01794	http://pfam.xfam.org/family/PF01794
Pfam	PF08022	http://pfam.xfam.org/family/PF08022
Pfam	PF08030	http://pfam.xfam.org/family/PF08030
Pfam	PF13202	http://pfam.xfam.org/family/PF13202
Pfam	PF13405	http://pfam.xfam.org/family/PF13405
PharmGKB	PA31693	http://www.pharmgkb.org/do/serve?objId=PA31693&objCls=Gene
Phobius	swissprot:NOX5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NOX5_HUMAN
PhylomeDB	Q96PH1	http://phylomedb.org/?seqid=Q96PH1
ProteinModelPortal	Q96PH1	http://www.proteinmodelportal.org/query/uniprot/Q96PH1
PubMed	11376945	http://www.ncbi.nlm.nih.gov/pubmed/11376945
PubMed	11483596	http://www.ncbi.nlm.nih.gov/pubmed/11483596
PubMed	12686516	http://www.ncbi.nlm.nih.gov/pubmed/12686516
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	14982937	http://www.ncbi.nlm.nih.gov/pubmed/14982937
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15994299	http://www.ncbi.nlm.nih.gov/pubmed/15994299
PubMed	16179589	http://www.ncbi.nlm.nih.gov/pubmed/16179589
PubMed	16339585	http://www.ncbi.nlm.nih.gov/pubmed/16339585
PubMed	16572171	http://www.ncbi.nlm.nih.gov/pubmed/16572171
PubMed	17275676	http://www.ncbi.nlm.nih.gov/pubmed/17275676
Reactome	R-HSA-3299685	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3299685
RefSeq	NP_001171708	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001171708
RefSeq	NP_001171709	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001171709
RefSeq	NP_078781	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_078781
SMART	SM00054	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00054
STRING	9606.ENSP00000373518	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000373518&targetmode=cogs
SUPFAM	SSF47473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47473
SUPFAM	SSF63380	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63380
TCDB	5.B.1.1	http://www.tcdb.org/search/result.php?tc=5.B.1.1
UCSC	uc002arp	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002arp&org=rat
UniGene	Hs.657932	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.657932
UniProtKB	NOX5_HUMAN	http://www.uniprot.org/uniprot/NOX5_HUMAN
UniProtKB-AC	Q96PH1	http://www.uniprot.org/uniprot/Q96PH1
charge	swissprot:NOX5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NOX5_HUMAN
eggNOG	ENOG410XNZY	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNZY
eggNOG	KOG0039	http://eggnogapi.embl.de/nog_data/html/tree/KOG0039
epestfind	swissprot:NOX5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NOX5_HUMAN
garnier	swissprot:NOX5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NOX5_HUMAN
helixturnhelix	swissprot:NOX5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NOX5_HUMAN
hmoment	swissprot:NOX5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NOX5_HUMAN
iep	swissprot:NOX5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NOX5_HUMAN
inforesidue	swissprot:NOX5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NOX5_HUMAN
neXtProt	NX_Q96PH1	http://www.nextprot.org/db/entry/NX_Q96PH1
octanol	swissprot:NOX5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NOX5_HUMAN
pepcoil	swissprot:NOX5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NOX5_HUMAN
pepdigest	swissprot:NOX5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NOX5_HUMAN
pepinfo	swissprot:NOX5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NOX5_HUMAN
pepnet	swissprot:NOX5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NOX5_HUMAN
pepstats	swissprot:NOX5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NOX5_HUMAN
pepwheel	swissprot:NOX5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NOX5_HUMAN
pepwindow	swissprot:NOX5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NOX5_HUMAN
sigcleave	swissprot:NOX5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NOX5_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SURF1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q15526-1; Sequence=Displayed; Name=2; IsoId=Q15526-2; Sequence=VSP_034817; Note=No experimental confirmation available.; 
# BioGrid	112701	23
# CCDS	CCDS6966	-. [Q15526-1]
# CDD	cd06662	SURF1
# DISEASE	SURF1_HUMAN	Charcot-Marie-Tooth disease 4K (CMT4K) [MIM 616684]  An autosomal recessive, demyelinating form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology  primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Demyelinating neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. By convention autosomal recessive forms of demyelinating Charcot-Marie-Tooth disease are designated CMT4. CMT4K patients manifest upper and lower limbs involvement. Some affected individuals have nystagmus and late-onset cerebellar ataxia. {ECO 0000269|PubMed 24027061}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SURF1_HUMAN	Leigh syndrome (LS) [MIM 256000]  An early-onset progressive neurodegenerative disorder characterized by the presence of focal, bilateral lesions in one or more areas of the central nervous system including the brainstem, thalamus, basal ganglia, cerebellum and spinal cord. Clinical features depend on which areas of the central nervous system are involved and include subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, and dysphagia. {ECO 0000269|PubMed 10647889, ECO 0000269|PubMed 10746561, ECO 0000269|PubMed 14564068, ECO 0000269|PubMed 21937992, ECO 0000269|PubMed 22410471, ECO 0000269|PubMed 22488715, ECO 0000269|PubMed 9843204}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000371974	ENSP00000361042; ENSG00000148290. [Q15526-1]
# Ensembl	ENST00000626663	ENSP00000487158; ENSG00000280627. [Q15526-1]
# ExpressionAtlas	Q15526	baseline and differential
# FUNCTION	SURF1_HUMAN	Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. {ECO 0000269|PubMed 24027061, ECO 0000269|PubMed 9843204, ECO 0000305|PubMed 26321642}. 
# GO_component	GO:0005746	mitochondrial respiratory chain; TAS:ProtInc.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0004129	cytochrome-c oxidase activity; TAS:ProtInc.
# GO_process	GO:0006119	oxidative phosphorylation; IMP:BHF-UCL.
# GO_process	GO:0006754	ATP biosynthetic process; IMP:BHF-UCL.
# GO_process	GO:0008535	respiratory chain complex IV assembly; TAS:ProtInc.
# GO_process	GO:0009060	aerobic respiration; TAS:ProtInc.
# GO_process	GO:0033617	mitochondrial respiratory chain complex IV assembly; IMP:UniProtKB.
# GO_process	GO:0055114	oxidation-reduction process; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# Genevisible	Q15526	HS
# HGNC	HGNC:11474	SURF1
# INTERACTION	SURF1_HUMAN	Q9Y2R0 COA3; NbExp=6; IntAct=EBI-3915286, EBI-6570446; 
# IntAct	Q15526	6
# InterPro	IPR002994	Surf1/Shy1
# KEGG_Disease	H01354	[Inherited metabolic disease; Neurodegenerative disease; Mitochondrial disease] X-linked Leigh syndrome
# KEGG_Disease	H01368:[Inherited metabolic disease; Mitochondrial disease] Leber Hereditary Optic Neuropathy (LHON) [DS	H00068]
# MIM	185620	gene
# MIM	256000	phenotype
# MIM	616684	phenotype
# Organism	SURF1_HUMAN	Homo sapiens (Human)
# Orphanet	1561	Fatal infantile cytochrome C oxidase deficiency
# Orphanet	255241	Leigh syndrome with leukodystrophy
# Orphanet	391351	SURF1-related Charcot-Marie-Tooth disease type 4
# Orphanet	70474	Leigh syndrome with cardiomyopathy
# PIR	S57749	S57749
# PROSITE	PS50895	SURF1
# Pfam	PF02104	SURF1
# Proteomes	UP000005640	Chromosome 9
# Reactome	R-HSA-5628897	TP53 Regulates Metabolic Genes
# Reactome	R-HSA-611105	Respiratory electron transport
# RecName	SURF1_HUMAN	Surfeit locus protein 1
# RefSeq	NP_001267716	NM_001280787.1
# RefSeq	NP_003163	NM_003172.3. [Q15526-1]
# SIMILARITY	Belongs to the SURF1 family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	SURF1_HUMAN	Mitochondrion inner membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUBUNIT	Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, the core components of this complex being COA3/MITRAC12 and COX14. Interacts with COA3. {ECO:0000269|PubMed	26321642}. 
# UCSC	uc004cdh	human. [Q15526-1]
# WEB RESOURCE	SURF1_HUMAN	Name=Surfeit 1 (SURF1); Note=Leiden Open Variation Database (LOVD); URL="http //www.lovd.nl/SURF1";
# eggNOG	COG3346	LUCA
# eggNOG	ENOG410KC4M	Eukaryota
BLAST	swissprot:SURF1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SURF1_HUMAN
BioCyc	ZFISH:ENSG00000148290-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000148290-MONOMER
COG	COG3346	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3346
COXPRESdb	6834	http://coxpresdb.jp/data/gene/6834.shtml
CleanEx	HS_SURF1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SURF1
DOI	10.1002/humu.1112.abs	http://dx.doi.org/10.1002/humu.1112.abs
DOI	10.1002/humu.22095	http://dx.doi.org/10.1002/humu.22095
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1007/s004390051028	http://dx.doi.org/10.1007/s004390051028
DOI	10.1007/s004399900191	http://dx.doi.org/10.1007/s004399900191
DOI	10.1016/j.braindev.2012.02.007	http://dx.doi.org/10.1016/j.braindev.2012.02.007
DOI	10.1016/j.celrep.2015.08.009	http://dx.doi.org/10.1016/j.celrep.2015.08.009
DOI	10.1038/3804	http://dx.doi.org/10.1038/3804
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
DOI	10.1038/nature10423	http://dx.doi.org/10.1038/nature10423
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1089/dna.1994.13.1117	http://dx.doi.org/10.1089/dna.1994.13.1117
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1212/WNL.0b013e3182a4a518	http://dx.doi.org/10.1212/WNL.0b013e3182a4a518
EMBL	AK291122	http://www.ebi.ac.uk/ena/data/view/AK291122
EMBL	AL158826	http://www.ebi.ac.uk/ena/data/view/AL158826
EMBL	AL158826	http://www.ebi.ac.uk/ena/data/view/AL158826
EMBL	BC028314	http://www.ebi.ac.uk/ena/data/view/BC028314
EMBL	BC071658	http://www.ebi.ac.uk/ena/data/view/BC071658
EMBL	Z35093	http://www.ebi.ac.uk/ena/data/view/Z35093
Ensembl	ENST00000371974	http://www.ensembl.org/id/ENST00000371974
Ensembl	ENST00000626663	http://www.ensembl.org/id/ENST00000626663
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005746	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005746
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0004129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004129
GO_process	GO:0006119	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006119
GO_process	GO:0006754	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006754
GO_process	GO:0008535	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008535
GO_process	GO:0009060	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009060
GO_process	GO:0033617	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033617
GO_process	GO:0055114	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GeneCards	SURF1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SURF1
GeneID	6834	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6834
GeneTree	ENSGT00530000064194	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000064194
HGNC	HGNC:11474	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11474
HOGENOM	HOG000097776	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000097776&db=HOGENOM6
HOVERGEN	HBG058486	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG058486&db=HOVERGEN
HPA	CAB033946	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB033946
HPA	HPA021029	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA021029
InParanoid	Q15526	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q15526
IntAct	Q15526	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q15526*
InterPro	IPR002994	http://www.ebi.ac.uk/interpro/entry/IPR002994
Jabion	6834	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6834
KEGG_Disease	H01354	http://www.genome.jp/dbget-bin/www_bget?H01354
KEGG_Disease	H01368	http://www.genome.jp/dbget-bin/www_bget?H01368
KEGG_Gene	hsa:6834	http://www.genome.jp/dbget-bin/www_bget?hsa:6834
KEGG_Orthology	KO:K14998	http://www.genome.jp/dbget-bin/www_bget?KO:K14998
MIM	185620	http://www.ncbi.nlm.nih.gov/omim/185620
MIM	256000	http://www.ncbi.nlm.nih.gov/omim/256000
MIM	616684	http://www.ncbi.nlm.nih.gov/omim/616684
OMA	HWYYRDL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HWYYRDL
Orphanet	1561	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1561
Orphanet	255241	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=255241
Orphanet	391351	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=391351
Orphanet	70474	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=70474
OrthoDB	EOG091G0IWR	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0IWR
PROSITE	PS50895	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50895
PSORT	swissprot:SURF1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SURF1_HUMAN
PSORT-B	swissprot:SURF1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SURF1_HUMAN
PSORT2	swissprot:SURF1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SURF1_HUMAN
Pfam	PF02104	http://pfam.xfam.org/family/PF02104
PharmGKB	PA36259	http://www.pharmgkb.org/do/serve?objId=PA36259&objCls=Gene
Phobius	swissprot:SURF1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SURF1_HUMAN
PhylomeDB	Q15526	http://phylomedb.org/?seqid=Q15526
ProteinModelPortal	Q15526	http://www.proteinmodelportal.org/query/uniprot/Q15526
PubMed	10647889	http://www.ncbi.nlm.nih.gov/pubmed/10647889
PubMed	10746561	http://www.ncbi.nlm.nih.gov/pubmed/10746561
PubMed	11317352	http://www.ncbi.nlm.nih.gov/pubmed/11317352
PubMed	14564068	http://www.ncbi.nlm.nih.gov/pubmed/14564068
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	21937992	http://www.ncbi.nlm.nih.gov/pubmed/21937992
PubMed	22410471	http://www.ncbi.nlm.nih.gov/pubmed/22410471
PubMed	22488715	http://www.ncbi.nlm.nih.gov/pubmed/22488715
PubMed	24027061	http://www.ncbi.nlm.nih.gov/pubmed/24027061
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	26321642	http://www.ncbi.nlm.nih.gov/pubmed/26321642
PubMed	7702754	http://www.ncbi.nlm.nih.gov/pubmed/7702754
PubMed	9843204	http://www.ncbi.nlm.nih.gov/pubmed/9843204
Reactome	R-HSA-5628897	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5628897
Reactome	R-HSA-611105	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-611105
RefSeq	NP_001267716	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001267716
RefSeq	NP_003163	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003163
STRING	9606.ENSP00000361042	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000361042&targetmode=cogs
STRING	COG3346	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3346&targetmode=cogs
UCSC	uc004cdh	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004cdh&org=rat
UniGene	Hs.512464	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.512464
UniProtKB	SURF1_HUMAN	http://www.uniprot.org/uniprot/SURF1_HUMAN
UniProtKB-AC	Q15526	http://www.uniprot.org/uniprot/Q15526
charge	swissprot:SURF1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SURF1_HUMAN
eggNOG	COG3346	http://eggnogapi.embl.de/nog_data/html/tree/COG3346
eggNOG	ENOG410KC4M	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410KC4M
epestfind	swissprot:SURF1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SURF1_HUMAN
garnier	swissprot:SURF1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SURF1_HUMAN
helixturnhelix	swissprot:SURF1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SURF1_HUMAN
hmoment	swissprot:SURF1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SURF1_HUMAN
iep	swissprot:SURF1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SURF1_HUMAN
inforesidue	swissprot:SURF1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SURF1_HUMAN
neXtProt	NX_Q15526	http://www.nextprot.org/db/entry/NX_Q15526
octanol	swissprot:SURF1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SURF1_HUMAN
pepcoil	swissprot:SURF1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SURF1_HUMAN
pepdigest	swissprot:SURF1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SURF1_HUMAN
pepinfo	swissprot:SURF1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SURF1_HUMAN
pepnet	swissprot:SURF1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SURF1_HUMAN
pepstats	swissprot:SURF1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SURF1_HUMAN
pepwheel	swissprot:SURF1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SURF1_HUMAN
pepwindow	swissprot:SURF1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SURF1_HUMAN
sigcleave	swissprot:SURF1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SURF1_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	123891	2
# ChiTaRS	SLC41A2	human
# Ensembl	ENST00000258538	ENSP00000258538; ENSG00000136052
# ExpressionAtlas	Q96JW4	baseline and differential
# FUNCTION	S41A2_HUMAN	Acts as a plasma-membrane magnesium transporter. {ECO 0000269|PubMed 16984228}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015095	magnesium ion transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0055085	transmembrane transport; IBA:GO_Central.
# GO_process	GO:0070838	divalent metal ion transport; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.10.357.20	-; 2.
# Genevisible	Q96JW4	HS
# HGNC	HGNC:31045	SLC41A2
# INTERACTION	S41A2_HUMAN	Q8N6L0 CCDC155; NbExp=5; IntAct=EBI-10290130, EBI-749265; 
# IntAct	Q96JW4	4
# InterPro	IPR006667	SLC41_membr_dom
# KEGG_Brite	ko02001	Solute carrier family
# MIM	610802	gene
# Organism	S41A2_HUMAN	Homo sapiens (Human)
# Pfam	PF01769	MgtE; 2
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-425410	Metal ion SLC transporters
# RecName	S41A2_HUMAN	Solute carrier family 41 member 2
# RefSeq	NP_115524	NM_032148.3
# RefSeq	XP_005269233	XM_005269176.1
# RefSeq	XP_005269235	XM_005269178.1
# RefSeq	XP_005269236	XM_005269179.1
# RefSeq	XP_006719693	XM_006719630.2
# RefSeq	XP_011537109	XM_011538807.2
# RefSeq	XP_011537110	XM_011538808.1
# RefSeq	XP_011537111	XM_011538809.1
# RefSeq	XP_011537112	XM_011538810.2
# RefSeq	XP_011537113	XM_011538811.2
# RefSeq	XP_016875502	XM_017020013.1
# SEQUENCE CAUTION	S41A2_HUMAN	Sequence=AAH36734.1; Type=Erroneous initiation; Evidence={ECO 0000305}; Sequence=AAI06872.2; Type=Erroneous initiation; Evidence={ECO 0000305}; Sequence=AAI06873.2; Type=Erroneous initiation; Evidence={ECO 0000305}; Sequence=BAB55402.1; Type=Frameshift; Positions=69, 101, 103; Evidence={ECO 0000305}; Sequence=CAB66762.1; Type=Erroneous initiation; Evidence={ECO 0000305};
# SIMILARITY	Belongs to the SLC41A transporter family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S41A2_HUMAN	Cell membrane {ECO 0000269|PubMed 16984228}; Multi-pass membrane protein {ECO 0000269|PubMed 16984228}. 
# TCDB	1.A.26.2	the mg(2+) transporter-e (mgte) family
# UCSC	uc001tla	human
# eggNOG	ENOG410XSTG	LUCA
# eggNOG	KOG3788	Eukaryota
BLAST	swissprot:S41A2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S41A2_HUMAN
BioCyc	ZFISH:ENSG00000136052-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000136052-MONOMER
COXPRESdb	84102	http://coxpresdb.jp/data/gene/84102.shtml
CleanEx	HS_SLC41A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC41A2
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/BJ20060673	http://dx.doi.org/10.1042/BJ20060673
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1101/gr.GR1547R	http://dx.doi.org/10.1101/gr.GR1547R
EMBL	AK027838	http://www.ebi.ac.uk/ena/data/view/AK027838
EMBL	AL136828	http://www.ebi.ac.uk/ena/data/view/AL136828
EMBL	BC036734	http://www.ebi.ac.uk/ena/data/view/BC036734
EMBL	BC106871	http://www.ebi.ac.uk/ena/data/view/BC106871
EMBL	BC106872	http://www.ebi.ac.uk/ena/data/view/BC106872
Ensembl	ENST00000258538	http://www.ensembl.org/id/ENST00000258538
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015095
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GO_process	GO:0070838	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070838
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.10.357.20	http://www.cathdb.info/version/latest/superfamily/1.10.357.20
GeneCards	SLC41A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC41A2
GeneID	84102	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84102
GeneTree	ENSGT00390000016816	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000016816
HGNC	HGNC:31045	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:31045
HOGENOM	HOG000007017	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007017&db=HOGENOM6
HOVERGEN	HBG057187	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG057187&db=HOVERGEN
HPA	HPA038658	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA038658
InParanoid	Q96JW4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96JW4
IntAct	Q96JW4	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96JW4*
InterPro	IPR006667	http://www.ebi.ac.uk/interpro/entry/IPR006667
Jabion	84102	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=84102
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:84102	http://www.genome.jp/dbget-bin/www_bget?hsa:84102
KEGG_Orthology	KO:K15122	http://www.genome.jp/dbget-bin/www_bget?KO:K15122
MIM	610802	http://www.ncbi.nlm.nih.gov/omim/610802
MINT	MINT-4722037	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4722037
OMA	YCDGREA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YCDGREA
OrthoDB	EOG091G08MB	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08MB
PSORT	swissprot:S41A2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S41A2_HUMAN
PSORT-B	swissprot:S41A2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S41A2_HUMAN
PSORT2	swissprot:S41A2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S41A2_HUMAN
Pfam	PF01769	http://pfam.xfam.org/family/PF01769
PharmGKB	PA134931432	http://www.pharmgkb.org/do/serve?objId=PA134931432&objCls=Gene
Phobius	swissprot:S41A2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S41A2_HUMAN
PhylomeDB	Q96JW4	http://phylomedb.org/?seqid=Q96JW4
ProteinModelPortal	Q96JW4	http://www.proteinmodelportal.org/query/uniprot/Q96JW4
PubMed	11230166	http://www.ncbi.nlm.nih.gov/pubmed/11230166
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16984228	http://www.ncbi.nlm.nih.gov/pubmed/16984228
Reactome	R-HSA-425410	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425410
RefSeq	NP_115524	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_115524
RefSeq	XP_005269233	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005269233
RefSeq	XP_005269235	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005269235
RefSeq	XP_005269236	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005269236
RefSeq	XP_006719693	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006719693
RefSeq	XP_011537109	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011537109
RefSeq	XP_011537110	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011537110
RefSeq	XP_011537111	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011537111
RefSeq	XP_011537112	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011537112
RefSeq	XP_011537113	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011537113
RefSeq	XP_016875502	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016875502
STRING	9606.ENSP00000258538	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000258538&targetmode=cogs
TCDB	1.A.26.2	http://www.tcdb.org/search/result.php?tc=1.A.26.2
UCSC	uc001tla	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001tla&org=rat
UniGene	Hs.577463	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.577463
UniProtKB	S41A2_HUMAN	http://www.uniprot.org/uniprot/S41A2_HUMAN
UniProtKB-AC	Q96JW4	http://www.uniprot.org/uniprot/Q96JW4
charge	swissprot:S41A2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S41A2_HUMAN
eggNOG	ENOG410XSTG	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSTG
eggNOG	KOG3788	http://eggnogapi.embl.de/nog_data/html/tree/KOG3788
epestfind	swissprot:S41A2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S41A2_HUMAN
garnier	swissprot:S41A2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S41A2_HUMAN
helixturnhelix	swissprot:S41A2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S41A2_HUMAN
hmoment	swissprot:S41A2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S41A2_HUMAN
iep	swissprot:S41A2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S41A2_HUMAN
inforesidue	swissprot:S41A2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S41A2_HUMAN
neXtProt	NX_Q96JW4	http://www.nextprot.org/db/entry/NX_Q96JW4
octanol	swissprot:S41A2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S41A2_HUMAN
pepcoil	swissprot:S41A2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S41A2_HUMAN
pepdigest	swissprot:S41A2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S41A2_HUMAN
pepinfo	swissprot:S41A2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S41A2_HUMAN
pepnet	swissprot:S41A2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S41A2_HUMAN
pepstats	swissprot:S41A2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S41A2_HUMAN
pepwheel	swissprot:S41A2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S41A2_HUMAN
pepwindow	swissprot:S41A2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S41A2_HUMAN
sigcleave	swissprot:S41A2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S41A2_HUMAN
## Database	ID	URL or Descriptions
# AltName	RHCG_HUMAN	Rh glycoprotein kidney
# AltName	RHCG_HUMAN	Rhesus blood group family type C glycoprotein
# AltName	RHCG_HUMAN	Tumor-related protein DRC2
# ChiTaRS	RHCG	human
# DEVELOPMENTAL STAGE	Specifically expressed in fetal kidney. {ECO:0000269|PubMed	10852913}. 
# Ensembl	ENST00000268122	ENSP00000268122; ENSG00000140519
# ExpressionAtlas	Q9UBD6	baseline and differential
# FUNCTION	RHCG_HUMAN	Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion. {ECO 0000269|PubMed 11062476, ECO 0000269|PubMed 14761968, ECO 0000269|PubMed 15929723, ECO 0000269|PubMed 16477434}. 
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016323	basolateral plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_component	GO:0031410	cytoplasmic vesicle; ISS:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0008519	ammonium transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0030506	ankyrin binding; IDA:UniProtKB.
# GO_process	GO:0006873	cellular ion homeostasis; IDA:UniProtKB.
# GO_process	GO:0006885	regulation of pH; IEA:Ensembl.
# GO_process	GO:0015695	organic cation transport; IBA:GO_Central.
# GO_process	GO:0015696	ammonium transport; IDA:UniProtKB.
# GO_process	GO:0015837	amine transport; NAS:UniProtKB.
# GO_process	GO:0019740	nitrogen utilization; IBA:GO_Central.
# GO_process	GO:0030855	epithelial cell differentiation; NAS:UniProtKB.
# GO_process	GO:0042592	homeostatic process; NAS:UniProtKB.
# GO_process	GO:0070634	transepithelial ammonium transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0008092	cytoskeletal protein binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0042592	homeostatic process
# Gene3D	1.10.3430.10	-; 1.
# Genevisible	Q9UBD6	HS
# HGNC	HGNC:18140	RHCG
# InterPro	IPR001905	Ammonium_transpt
# InterPro	IPR002229	RhesusRHD
# InterPro	IPR024041	NH4_transpt_AmtB-like_dom
# InterPro	IPR029020	Ammonium/urea_transptr
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Brite	ko04090	 Cellular antigens
# MIM	605381	gene
# Organism	RHCG_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11730	PTHR11730
# PDB	3HD6	X-ray; 2.10 A; A=2-479
# PRINTS	PR00342	RHESUSRHD
# PTM	RHCG_HUMAN	N-glycosylated. {ECO 0000269|PubMed 10852913, ECO 0000269|PubMed 20457942}. 
# Pfam	PF00909	Ammonium_transp
# Proteomes	UP000005640	Chromosome 15
# Reactome	R-HSA-444411	Rhesus glycoproteins mediate ammonium transport
# RecName	RHCG_HUMAN	Ammonium transporter Rh type C
# RefSeq	NP_001307970	NM_001321041.1
# RefSeq	NP_057405	NM_016321.2
# SIMILARITY	Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	RHCG_HUMAN	Apical cell membrane {ECO 0000269|PubMed 10852913, ECO 0000269|PubMed 12204676}; Multi- pass membrane protein {ECO 0000269|PubMed 10852913, ECO 0000269|PubMed 12204676}. Note=Also detected at the basolateral membrane and in subapical vesicles. {ECO 0000250}. 
# SUBUNIT	Homotrimer. {ECO:0000269|PubMed	20457942}. 
# SUPFAM	SSF111352	SSF111352
# TCDB	1.A.11.4	the ammonium transporter channel (amt) family
# TISSUE SPECIFICITY	RHCG_HUMAN	Expressed in brain, testis, placenta, pancreas, esophagus and prostate. Expressed in squamous epithelial tissues (at protein level). According to PubMed 11062476, specifically expressed in kidney. {ECO 0000269|PubMed 10852913, ECO 0000269|PubMed 11062476, ECO 0000269|PubMed 12204676}. 
# UCSC	uc002bnz	human
# eggNOG	ENOG410XTF8	LUCA
# eggNOG	KOG3796	Eukaryota
BLAST	swissprot:RHCG_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:RHCG_HUMAN
BioCyc	ZFISH:ENSG00000140519-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000140519-MONOMER
COXPRESdb	51458	http://coxpresdb.jp/data/gene/51458.shtml
CleanEx	HS_RHCG	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_RHCG
DIP	DIP-59334N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-59334N
DOI	10.1007/s00294-006-0062-5	http://dx.doi.org/10.1007/s00294-006-0062-5
DOI	10.1016/S0959-8049(02)00190-9	http://dx.doi.org/10.1016/S0959-8049(02)00190-9
DOI	10.1016/j.tracli.2006.02.025	http://dx.doi.org/10.1016/j.tracli.2006.02.025
DOI	10.1038/81656	http://dx.doi.org/10.1038/81656
DOI	10.1038/nature04601	http://dx.doi.org/10.1038/nature04601
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/BJ20050657	http://dx.doi.org/10.1042/BJ20050657
DOI	10.1073/pnas.1003587107	http://dx.doi.org/10.1073/pnas.1003587107
DOI	10.1074/jbc.M003353200	http://dx.doi.org/10.1074/jbc.M003353200
DOI	10.1074/jbc.M308528200	http://dx.doi.org/10.1074/jbc.M308528200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC013391	http://www.ebi.ac.uk/ena/data/view/AC013391
EMBL	AF081497	http://www.ebi.ac.uk/ena/data/view/AF081497
EMBL	AF193809	http://www.ebi.ac.uk/ena/data/view/AF193809
EMBL	AF219981	http://www.ebi.ac.uk/ena/data/view/AF219981
EMBL	AF219982	http://www.ebi.ac.uk/ena/data/view/AF219982
EMBL	AF219983	http://www.ebi.ac.uk/ena/data/view/AF219983
EMBL	AF219984	http://www.ebi.ac.uk/ena/data/view/AF219984
EMBL	AF219985	http://www.ebi.ac.uk/ena/data/view/AF219985
EMBL	AF219986	http://www.ebi.ac.uk/ena/data/view/AF219986
EMBL	AF284446	http://www.ebi.ac.uk/ena/data/view/AF284446
EMBL	AK290899	http://www.ebi.ac.uk/ena/data/view/AK290899
EMBL	AK313238	http://www.ebi.ac.uk/ena/data/view/AK313238
EMBL	AY257182	http://www.ebi.ac.uk/ena/data/view/AY257182
EMBL	BC030965	http://www.ebi.ac.uk/ena/data/view/BC030965
EMBL	CH471101	http://www.ebi.ac.uk/ena/data/view/CH471101
Ensembl	ENST00000268122	http://www.ensembl.org/id/ENST00000268122
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0008519	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008519
GO_function	GO:0030506	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030506
GO_process	GO:0006873	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006873
GO_process	GO:0006885	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006885
GO_process	GO:0015695	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015695
GO_process	GO:0015696	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015696
GO_process	GO:0015837	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015837
GO_process	GO:0019740	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019740
GO_process	GO:0030855	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030855
GO_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GO_process	GO:0070634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070634
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0008092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
Gene3D	1.10.3430.10	http://www.cathdb.info/version/latest/superfamily/1.10.3430.10
GeneCards	RHCG	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=RHCG
GeneID	51458	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51458
GeneTree	ENSGT00390000005787	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000005787
HGNC	HGNC:18140	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18140
HOGENOM	HOG000007656	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007656&db=HOGENOM6
HOVERGEN	HBG004374	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004374&db=HOVERGEN
HPA	HPA041874	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA041874
HPA	HPA043317	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA043317
InParanoid	Q9UBD6	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UBD6
InterPro	IPR001905	http://www.ebi.ac.uk/interpro/entry/IPR001905
InterPro	IPR002229	http://www.ebi.ac.uk/interpro/entry/IPR002229
InterPro	IPR024041	http://www.ebi.ac.uk/interpro/entry/IPR024041
InterPro	IPR029020	http://www.ebi.ac.uk/interpro/entry/IPR029020
Jabion	51458	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=51458
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Brite	ko04090	http://www.genome.jp/dbget-bin/www_bget?ko04090
KEGG_Gene	hsa:51458	http://www.genome.jp/dbget-bin/www_bget?hsa:51458
KEGG_Orthology	KO:K06580	http://www.genome.jp/dbget-bin/www_bget?KO:K06580
MIM	605381	http://www.ncbi.nlm.nih.gov/omim/605381
OMA	DMENEFY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DMENEFY
OrthoDB	EOG091G06KX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G06KX
PANTHER	PTHR11730	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11730
PDB	3HD6	http://www.ebi.ac.uk/pdbe-srv/view/entry/3HD6
PDBsum	3HD6	http://www.ebi.ac.uk/pdbsum/3HD6
PRINTS	PR00342	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00342
PSORT	swissprot:RHCG_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:RHCG_HUMAN
PSORT-B	swissprot:RHCG_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:RHCG_HUMAN
PSORT2	swissprot:RHCG_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:RHCG_HUMAN
Pfam	PF00909	http://pfam.xfam.org/family/PF00909
PharmGKB	PA134876043	http://www.pharmgkb.org/do/serve?objId=PA134876043&objCls=Gene
Phobius	swissprot:RHCG_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:RHCG_HUMAN
PhylomeDB	Q9UBD6	http://phylomedb.org/?seqid=Q9UBD6
ProteinModelPortal	Q9UBD6	http://www.proteinmodelportal.org/query/uniprot/Q9UBD6
PubMed	10852913	http://www.ncbi.nlm.nih.gov/pubmed/10852913
PubMed	11062476	http://www.ncbi.nlm.nih.gov/pubmed/11062476
PubMed	12204676	http://www.ncbi.nlm.nih.gov/pubmed/12204676
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	14761968	http://www.ncbi.nlm.nih.gov/pubmed/14761968
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15929723	http://www.ncbi.nlm.nih.gov/pubmed/15929723
PubMed	16477434	http://www.ncbi.nlm.nih.gov/pubmed/16477434
PubMed	16572171	http://www.ncbi.nlm.nih.gov/pubmed/16572171
PubMed	16580862	http://www.ncbi.nlm.nih.gov/pubmed/16580862
PubMed	20457942	http://www.ncbi.nlm.nih.gov/pubmed/20457942
Reactome	R-HSA-444411	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-444411
RefSeq	NP_001307970	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001307970
RefSeq	NP_057405	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_057405
SMR	Q9UBD6	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9UBD6
STRING	9606.ENSP00000268122	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000268122&targetmode=cogs
SUPFAM	SSF111352	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF111352
TCDB	1.A.11.4	http://www.tcdb.org/search/result.php?tc=1.A.11.4
UCSC	uc002bnz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002bnz&org=rat
UniGene	Hs.459284	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.459284
UniProtKB	RHCG_HUMAN	http://www.uniprot.org/uniprot/RHCG_HUMAN
UniProtKB-AC	Q9UBD6	http://www.uniprot.org/uniprot/Q9UBD6
charge	swissprot:RHCG_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:RHCG_HUMAN
eggNOG	ENOG410XTF8	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XTF8
eggNOG	KOG3796	http://eggnogapi.embl.de/nog_data/html/tree/KOG3796
epestfind	swissprot:RHCG_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:RHCG_HUMAN
garnier	swissprot:RHCG_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:RHCG_HUMAN
helixturnhelix	swissprot:RHCG_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:RHCG_HUMAN
hmoment	swissprot:RHCG_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:RHCG_HUMAN
iep	swissprot:RHCG_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:RHCG_HUMAN
inforesidue	swissprot:RHCG_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:RHCG_HUMAN
neXtProt	NX_Q9UBD6	http://www.nextprot.org/db/entry/NX_Q9UBD6
octanol	swissprot:RHCG_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:RHCG_HUMAN
pepcoil	swissprot:RHCG_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:RHCG_HUMAN
pepdigest	swissprot:RHCG_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:RHCG_HUMAN
pepinfo	swissprot:RHCG_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:RHCG_HUMAN
pepnet	swissprot:RHCG_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:RHCG_HUMAN
pepstats	swissprot:RHCG_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:RHCG_HUMAN
pepwheel	swissprot:RHCG_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:RHCG_HUMAN
pepwindow	swissprot:RHCG_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:RHCG_HUMAN
sigcleave	swissprot:RHCG_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:RHCG_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	LOXH1_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8IVV2-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=3; IsoId=Q8IVV2-3; Sequence=VSP_028948; Name=4; IsoId=Q8IVV2-4; Sequence=VSP_028947, VSP_028951; Note=No experimental confirmation available.; Name=5; IsoId=Q8IVV2-5; Sequence=VSP_028947, VSP_028952; Note=No experimental confirmation available.; 
# CCDS	CCDS45861	-. [Q8IVV2-3]
# CCDS	CCDS45862	-. [Q8IVV2-5]
# CCDS	CCDS54184	-. [Q8IVV2-4]
# ChiTaRS	LOXHD1	human
# DISEASE	LOXH1_HUMAN	Deafness, autosomal recessive, 77 (DFNB77) [MIM 613079]  A form of non-syndromic deafness characterized by preserved low- frequency hearing, and a trend toward mild to moderate mid- frequency and high-frequency hearing loss during childhood and adolescence. Hearing loss progresses to become moderate to severe at mid and high frequencies during adulthood. {ECO 0000269|PubMed 19732867}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000300591	ENSP00000300591; ENSG00000167210. [Q8IVV2-3]
# Ensembl	ENST00000398686	ENSP00000381676; ENSG00000167210. [Q8IVV2-5]
# Ensembl	ENST00000398705	ENSP00000381692; ENSG00000167210. [Q8IVV2-4]
# ExpressionAtlas	Q8IVV2	baseline and differential
# FUNCTION	LOXH1_HUMAN	Involved in hearing. Required for normal function of hair cells in the inner ear (By similarity). {ECO 0000250, ECO 0000269|PubMed 19732867}. 
# GO_component	GO:0016020	membrane; IBA:GO_Central.
# GO_component	GO:0032420	stereocilium; ISS:UniProtKB.
# GO_function	GO:0005262	calcium channel activity; IBA:GO_Central.
# GO_process	GO:0007605	sensory perception of sound; IMP:UniProtKB.
# GO_process	GO:0050982	detection of mechanical stimulus; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# Gene3D	2.60.60.20	-; 15.
# Genevisible	Q8IVV2	HS
# HGNC	HGNC:26521	LOXHD1
# InterPro	IPR001024	PLAT/LH2_dom
# InterPro	IPR033033	LOXHD1
# KEGG_Disease	H00605	[Nervous system disease; Nervous system disease] Deafness, autosomal recessive
# MIM	613072	gene
# MIM	613079	phenotype
# Organism	LOXH1_HUMAN	Homo sapiens (Human)
# Orphanet	90636	Autosomal recessive non-syndromic sensorineural deafness type DFNB
# PANTHER	PTHR10877:SF137	PTHR10877:SF137
# PROSITE	PS50095	PLAT; 14
# Pfam	PF01477	PLAT; 14
# Proteomes	UP000005640	Chromosome 18
# RecName	LOXH1_HUMAN	Lipoxygenase homology domain-containing protein 1
# RefSeq	NP_001138944	NM_001145472.2. [Q8IVV2-3]
# RefSeq	NP_001138945	NM_001145473.2. [Q8IVV2-5]
# RefSeq	NP_001166600	NM_001173129.1. [Q8IVV2-4]
# RefSeq	NP_653213	NM_144612.6
# RefSeq	XP_011524113	XM_011525811.2. [Q8IVV2-5]
# SIMILARITY	Contains 14 PLAT domains. {ECO:0000255|PROSITE- ProRule	PRU00152}.
# SMART	SM00308	LH2; 9
# SUBCELLULAR LOCATION	LOXH1_HUMAN	Cell projection, stereocilium {ECO 0000250}. 
# SUPFAM	SSF49723	SSF49723; 14
# UCSC	uc002lcd	human. [Q8IVV2-1]
# eggNOG	ENOG410IJEB	Eukaryota
# eggNOG	ENOG410XTDU	LUCA
BLAST	swissprot:LOXH1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:LOXH1_HUMAN
COXPRESdb	125336	http://coxpresdb.jp/data/gene/125336.shtml
CleanEx	HS_LOXHD1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_LOXHD1
DOI	10.1016/j.ajhg.2009.07.017	http://dx.doi.org/10.1016/j.ajhg.2009.07.017
DOI	10.1038/nature03983	http://dx.doi.org/10.1038/nature03983
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC018931	http://www.ebi.ac.uk/ena/data/view/AC018931
EMBL	AC064800	http://www.ebi.ac.uk/ena/data/view/AC064800
EMBL	AC091139	http://www.ebi.ac.uk/ena/data/view/AC091139
EMBL	AK057232	http://www.ebi.ac.uk/ena/data/view/AK057232
EMBL	AK127869	http://www.ebi.ac.uk/ena/data/view/AK127869
EMBL	BC041860	http://www.ebi.ac.uk/ena/data/view/BC041860
EMBL	BC047720	http://www.ebi.ac.uk/ena/data/view/BC047720
EMBL	CH471088	http://www.ebi.ac.uk/ena/data/view/CH471088
EMBL	CH471088	http://www.ebi.ac.uk/ena/data/view/CH471088
Ensembl	ENST00000300591	http://www.ensembl.org/id/ENST00000300591
Ensembl	ENST00000398686	http://www.ensembl.org/id/ENST00000398686
Ensembl	ENST00000398705	http://www.ensembl.org/id/ENST00000398705
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0032420	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032420
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_process	GO:0007605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007605
GO_process	GO:0050982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050982
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
Gene3D	2.60.60.20	http://www.cathdb.info/version/latest/superfamily/2.60.60.20
GeneCards	LOXHD1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=LOXHD1
GeneID	125336	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=125336
GeneTree	ENSGT00390000018830	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000018830
HGNC	HGNC:26521	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:26521
HOVERGEN	HBG108091	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108091&db=HOVERGEN
HPA	HPA042982	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042982
InParanoid	Q8IVV2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8IVV2
InterPro	IPR001024	http://www.ebi.ac.uk/interpro/entry/IPR001024
InterPro	IPR033033	http://www.ebi.ac.uk/interpro/entry/IPR033033
Jabion	125336	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=125336
KEGG_Disease	H00605	http://www.genome.jp/dbget-bin/www_bget?H00605
KEGG_Gene	hsa:125336	http://www.genome.jp/dbget-bin/www_bget?hsa:125336
MIM	613072	http://www.ncbi.nlm.nih.gov/omim/613072
MIM	613079	http://www.ncbi.nlm.nih.gov/omim/613079
Orphanet	90636	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=90636
PANTHER	PTHR10877:SF137	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10877:SF137
PROSITE	PS50095	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50095
PSORT	swissprot:LOXH1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:LOXH1_HUMAN
PSORT-B	swissprot:LOXH1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:LOXH1_HUMAN
PSORT2	swissprot:LOXH1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:LOXH1_HUMAN
Pfam	PF01477	http://pfam.xfam.org/family/PF01477
PharmGKB	PA134878065	http://www.pharmgkb.org/do/serve?objId=PA134878065&objCls=Gene
Phobius	swissprot:LOXH1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:LOXH1_HUMAN
PhylomeDB	Q8IVV2	http://phylomedb.org/?seqid=Q8IVV2
ProteinModelPortal	Q8IVV2	http://www.proteinmodelportal.org/query/uniprot/Q8IVV2
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16177791	http://www.ncbi.nlm.nih.gov/pubmed/16177791
PubMed	19732867	http://www.ncbi.nlm.nih.gov/pubmed/19732867
RefSeq	NP_001138944	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001138944
RefSeq	NP_001138945	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001138945
RefSeq	NP_001166600	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001166600
RefSeq	NP_653213	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_653213
RefSeq	XP_011524113	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011524113
SMART	SM00308	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00308
SMR	Q8IVV2	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8IVV2
STRING	9606.ENSP00000300591	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000300591&targetmode=cogs
SUPFAM	SSF49723	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49723
UCSC	uc002lcd	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002lcd&org=rat
UniGene	Hs.345877	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.345877
UniProtKB	LOXH1_HUMAN	http://www.uniprot.org/uniprot/LOXH1_HUMAN
UniProtKB-AC	Q8IVV2	http://www.uniprot.org/uniprot/Q8IVV2
charge	swissprot:LOXH1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:LOXH1_HUMAN
eggNOG	ENOG410IJEB	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IJEB
eggNOG	ENOG410XTDU	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XTDU
epestfind	swissprot:LOXH1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:LOXH1_HUMAN
garnier	swissprot:LOXH1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:LOXH1_HUMAN
helixturnhelix	swissprot:LOXH1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:LOXH1_HUMAN
hmoment	swissprot:LOXH1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:LOXH1_HUMAN
iep	swissprot:LOXH1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:LOXH1_HUMAN
inforesidue	swissprot:LOXH1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:LOXH1_HUMAN
neXtProt	NX_Q8IVV2	http://www.nextprot.org/db/entry/NX_Q8IVV2
octanol	swissprot:LOXH1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:LOXH1_HUMAN
pepcoil	swissprot:LOXH1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:LOXH1_HUMAN
pepdigest	swissprot:LOXH1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:LOXH1_HUMAN
pepinfo	swissprot:LOXH1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:LOXH1_HUMAN
pepnet	swissprot:LOXH1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:LOXH1_HUMAN
pepstats	swissprot:LOXH1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:LOXH1_HUMAN
pepwheel	swissprot:LOXH1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:LOXH1_HUMAN
pepwindow	swissprot:LOXH1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:LOXH1_HUMAN
sigcleave	swissprot:LOXH1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:LOXH1_HUMAN
## Database	ID	URL or Descriptions
# AltName	CCG8_HUMAN	Neuronal voltage-gated calcium channel gamma-8 subunit
# AltName	CCG8_HUMAN	Transmembrane AMPAR regulatory protein gamma-8
# ChiTaRS	CACNG8	human
# Ensembl	ENST00000270458	ENSP00000270458; ENSG00000142408
# FUNCTION	CCG8_HUMAN	Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. {ECO 0000269|PubMed 20805473, ECO 0000269|PubMed 21172611}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005891	voltage-gated calcium channel complex; NAS:UniProtKB.
# GO_component	GO:0014069	postsynaptic density; ISS:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030666	endocytic vesicle membrane; TAS:Reactome.
# GO_component	GO:0032281	AMPA glutamate receptor complex; ISS:UniProtKB.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005245	voltage-gated calcium channel activity; NAS:UniProtKB.
# GO_function	GO:0016247	channel regulator activity; IBA:GO_Central.
# GO_process	GO:0006816	calcium ion transport; NAS:UniProtKB.
# GO_process	GO:0019226	transmission of nerve impulse; IBA:GO_Central.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:0070588	calcium ion transmembrane transport; IBA:GO_Central.
# GO_process	GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q8WXS5	HS
# HGNC	HGNC:13628	CACNG8
# InterPro	IPR004031	PMP22/EMP/MP20/Claudin
# InterPro	IPR008368	VDCC_gsu
# InterPro	IPR008372	VDCC_g8su
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04010	MAPK signaling pathway
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05410	Hypertrophic cardiomyopathy (HCM)
# KEGG_Pathway	ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
# KEGG_Pathway	ko05414	Dilated cardiomyopathy
# MIM	606900	gene
# Organism	CCG8_HUMAN	Homo sapiens (Human)
# PRINTS	PR01792	VDCCGAMMA
# PRINTS	PR01796	VDCCGAMMA8
# Pfam	PF00822	PMP22_Claudin
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-399719	Trafficking of AMPA receptors
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# Reactome	R-HSA-5576893	Phase 2 - plateau phase
# Reactome	R-HSA-5576894	Phase 1 - inactivation of fast Na+ channels
# Reactome	R-HSA-5682910	LGI-ADAM interactions
# RecName	CCG8_HUMAN	Voltage-dependent calcium channel gamma-8 subunit
# RefSeq	NP_114101	NM_031895.5
# SEQUENCE CAUTION	Sequence=AAK15019.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=AAL50049.1; Type=Frameshift; Positions=Several; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	CCG8_HUMAN	Membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO 0000250}. 
# SUBUNIT	The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5 and CACNG7. Interacts with CNIH2 (By similarity). {ECO	0000250}. 
# TCDB	8.A.16.2	the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family
# UCSC	uc061clu	human
# eggNOG	ENOG410IJVW	Eukaryota
# eggNOG	ENOG4110B1C	LUCA
BLAST	swissprot:CCG8_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CCG8_HUMAN
BioCyc	ZFISH:ENSG00000142408-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000142408-MONOMER
COXPRESdb	59283	http://coxpresdb.jp/data/gene/59283.shtml
CleanEx	HS_CACNG6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CACNG6
CleanEx	HS_CACNG8	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CACNG8
DOI	10.1006/geno.2000.6440	http://dx.doi.org/10.1006/geno.2000.6440
DOI	10.1016/S0378-1119(01)00738-7	http://dx.doi.org/10.1016/S0378-1119(01)00738-7
DOI	10.1016/j.neuron.2010.11.026	http://dx.doi.org/10.1016/j.neuron.2010.11.026
DOI	10.1038/nature02399	http://dx.doi.org/10.1038/nature02399
DOI	10.1073/pnas.1011706107	http://dx.doi.org/10.1073/pnas.1011706107
EMBL	AC008440	http://www.ebi.ac.uk/ena/data/view/AC008440
EMBL	AF234892	http://www.ebi.ac.uk/ena/data/view/AF234892
EMBL	AF288388	http://www.ebi.ac.uk/ena/data/view/AF288388
EMBL	AF361354	http://www.ebi.ac.uk/ena/data/view/AF361354
Ensembl	ENST00000270458	http://www.ensembl.org/id/ENST00000270458
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005891
GO_component	GO:0014069	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014069
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030666
GO_component	GO:0032281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032281
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0016247	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016247
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0019226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019226
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:2000311	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000311
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	CACNG8	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CACNG8
GeneID	59283	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=59283
H-InvDB	HIX0202898	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0202898
HGNC	HGNC:13628	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13628
HOGENOM	HOG000233440	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233440&db=HOGENOM6
HOVERGEN	HBG003682	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003682&db=HOVERGEN
HPA	HPA041351	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA041351
InParanoid	Q8WXS5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8WXS5
InterPro	IPR004031	http://www.ebi.ac.uk/interpro/entry/IPR004031
InterPro	IPR008368	http://www.ebi.ac.uk/interpro/entry/IPR008368
InterPro	IPR008372	http://www.ebi.ac.uk/interpro/entry/IPR008372
Jabion	59283	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=59283
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:59283	http://www.genome.jp/dbget-bin/www_bget?hsa:59283
KEGG_Orthology	KO:K04873	http://www.genome.jp/dbget-bin/www_bget?KO:K04873
KEGG_Pathway	ko04010	http://www.genome.jp/kegg-bin/show_pathway?ko04010
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05410	http://www.genome.jp/kegg-bin/show_pathway?ko05410
KEGG_Pathway	ko05412	http://www.genome.jp/kegg-bin/show_pathway?ko05412
KEGG_Pathway	ko05414	http://www.genome.jp/kegg-bin/show_pathway?ko05414
MIM	606900	http://www.ncbi.nlm.nih.gov/omim/606900
OrthoDB	EOG091G0D2Z	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0D2Z
PRINTS	PR01792	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01792
PRINTS	PR01796	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01796
PSORT	swissprot:CCG8_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CCG8_HUMAN
PSORT-B	swissprot:CCG8_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CCG8_HUMAN
PSORT2	swissprot:CCG8_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CCG8_HUMAN
Pfam	PF00822	http://pfam.xfam.org/family/PF00822
PharmGKB	PA26022	http://www.pharmgkb.org/do/serve?objId=PA26022&objCls=Gene
Phobius	swissprot:CCG8_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CCG8_HUMAN
PhylomeDB	Q8WXS5	http://phylomedb.org/?seqid=Q8WXS5
ProteinModelPortal	Q8WXS5	http://www.proteinmodelportal.org/query/uniprot/Q8WXS5
PubMed	11170751	http://www.ncbi.nlm.nih.gov/pubmed/11170751
PubMed	11738816	http://www.ncbi.nlm.nih.gov/pubmed/11738816
PubMed	15057824	http://www.ncbi.nlm.nih.gov/pubmed/15057824
PubMed	20805473	http://www.ncbi.nlm.nih.gov/pubmed/20805473
PubMed	21172611	http://www.ncbi.nlm.nih.gov/pubmed/21172611
Reactome	R-HSA-399719	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-399719
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
Reactome	R-HSA-5576893	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576893
Reactome	R-HSA-5576894	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576894
Reactome	R-HSA-5682910	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5682910
RefSeq	NP_114101	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_114101
STRING	9606.ENSP00000270458	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000270458&targetmode=cogs
TCDB	8.A.16.2	http://www.tcdb.org/search/result.php?tc=8.A.16.2
UCSC	uc061clu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc061clu&org=rat
UniGene	Hs.631595	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.631595
UniProtKB	CCG8_HUMAN	http://www.uniprot.org/uniprot/CCG8_HUMAN
UniProtKB-AC	Q8WXS5	http://www.uniprot.org/uniprot/Q8WXS5
charge	swissprot:CCG8_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CCG8_HUMAN
eggNOG	ENOG410IJVW	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IJVW
eggNOG	ENOG4110B1C	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110B1C
epestfind	swissprot:CCG8_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CCG8_HUMAN
garnier	swissprot:CCG8_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CCG8_HUMAN
helixturnhelix	swissprot:CCG8_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CCG8_HUMAN
hmoment	swissprot:CCG8_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CCG8_HUMAN
iep	swissprot:CCG8_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CCG8_HUMAN
inforesidue	swissprot:CCG8_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CCG8_HUMAN
neXtProt	NX_Q8WXS5	http://www.nextprot.org/db/entry/NX_Q8WXS5
octanol	swissprot:CCG8_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CCG8_HUMAN
pepcoil	swissprot:CCG8_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CCG8_HUMAN
pepdigest	swissprot:CCG8_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CCG8_HUMAN
pepinfo	swissprot:CCG8_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CCG8_HUMAN
pepnet	swissprot:CCG8_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CCG8_HUMAN
pepstats	swissprot:CCG8_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CCG8_HUMAN
pepwheel	swissprot:CCG8_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CCG8_HUMAN
pepwindow	swissprot:CCG8_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CCG8_HUMAN
sigcleave	swissprot:CCG8_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CCG8_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ABCG4_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=B; IsoId=Q9H172-1; Sequence=Displayed; Name=2; Synonyms=T3, T4; IsoId=Q9H172-2; Sequence=VSP_054267; Name=3; Synonyms=M, T1; IsoId=Q9H172-3; Sequence=VSP_054268; Name=4; Synonyms=T2; IsoId=Q9H172-4; Sequence=VSP_054266; 
# CCDS	CCDS8415	-. [Q9H172-1]
# Ensembl	ENST00000615496	ENSP00000479253; ENSG00000172350. [Q9H172-1]
# Ensembl	ENST00000619701	ENSP00000481728; ENSG00000172350. [Q9H172-1]
# Ensembl	ENST00000622721	ENSP00000484289; ENSG00000172350. [Q9H172-1]
# ExpressionAtlas	Q9H172	baseline and differential
# FUNCTION	ABCG4_HUMAN	May be involved in macrophage lipid homeostasis. 
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IBA:GO_Central.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0017127	cholesterol transporter activity; IBA:GO_Central.
# GO_function	GO:0034041	sterol-transporting ATPase activity; IBA:GO_Central.
# GO_function	GO:0042803	protein homodimerization activity; IDA:BHF-UCL.
# GO_function	GO:0046982	protein heterodimerization activity; IPI:BHF-UCL.
# GO_process	GO:0033344	cholesterol efflux; TAS:BHF-UCL.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 1.
# Genevisible	Q9H172	HS
# HGNC	HGNC:13884	ABCG4
# INTERACTION	ABCG4_HUMAN	P45844-4 ABCG1; NbExp=2; IntAct=EBI-8584118, EBI-8584087; 
# IntAct	Q9H172	2
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR013525	ABC_2_trans
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko02010	ABC transporters
# MIM	607784	gene
# Organism	ABCG4_HUMAN	Homo sapiens (Human)
# PIR	JC7777	JC7777
# PROSITE	PS00211	ABC_TRANSPORTER_1
# PROSITE	PS50893	ABC_TRANSPORTER_2
# Pfam	PF00005	ABC_tran
# Pfam	PF01061	ABC2_membrane
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-1369062	ABC transporters in lipid homeostasis
# RecName	ABCG4_HUMAN	ATP-binding cassette sub-family G member 4
# RefSeq	NP_001135977	NM_001142505.1. [Q9H172-1]
# RefSeq	NP_071452	NM_022169.4. [Q9H172-1]
# RefSeq	XP_011541254	XM_011542952.2. [Q9H172-3]
# RefSeq	XP_016873610	XM_017018121.1. [Q9H172-2]
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 ABC transmembrane type-2 domain. {ECO	0000305}. 
# SIMILARITY	Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA
# SUBCELLULAR LOCATION	ABCG4_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF52540	SSF52540
# TCDB	3.A.1.204.20	the atp-binding cassette (abc) superfamily
# TISSUE SPECIFICITY	Highly expressed in brain tissues with the exception of the spinal cord. {ECO:0000269|PubMed	11856881}. 
# UCSC	uc031yhk	human. [Q9H172-1]
# WEB RESOURCE	ABCG4_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=Q9H172";
# eggNOG	COG1131	LUCA
# eggNOG	KOG0061	Eukaryota
BLAST	swissprot:ABCG4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCG4_HUMAN
BioCyc	ZFISH:ENSG00000172350-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000172350-MONOMER
COXPRESdb	64137	http://coxpresdb.jp/data/gene/64137.shtml
CleanEx	HS_ABCG4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCG4
DOI	10.1006/bbrc.2001.5756	http://dx.doi.org/10.1006/bbrc.2001.5756
DOI	10.1016/S0167-4889(02)00269-0	http://dx.doi.org/10.1016/S0167-4889(02)00269-0
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AJ300465	http://www.ebi.ac.uk/ena/data/view/AJ300465
EMBL	AJ308237	http://www.ebi.ac.uk/ena/data/view/AJ308237
EMBL	AK289830	http://www.ebi.ac.uk/ena/data/view/AK289830
EMBL	AK290035	http://www.ebi.ac.uk/ena/data/view/AK290035
EMBL	AY055472	http://www.ebi.ac.uk/ena/data/view/AY055472
EMBL	AY055472	http://www.ebi.ac.uk/ena/data/view/AY055472
EMBL	AY055472	http://www.ebi.ac.uk/ena/data/view/AY055472
EMBL	BC041091	http://www.ebi.ac.uk/ena/data/view/BC041091
EMBL	CH471065	http://www.ebi.ac.uk/ena/data/view/CH471065
EMBL	CH471065	http://www.ebi.ac.uk/ena/data/view/CH471065
EMBL	CH471065	http://www.ebi.ac.uk/ena/data/view/CH471065
Ensembl	ENST00000615496	http://www.ensembl.org/id/ENST00000615496
Ensembl	ENST00000619701	http://www.ensembl.org/id/ENST00000619701
Ensembl	ENST00000622721	http://www.ensembl.org/id/ENST00000622721
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0017127	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017127
GO_function	GO:0034041	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034041
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_function	GO:0046982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046982
GO_process	GO:0033344	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033344
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCG4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCG4
GeneID	64137	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64137
GeneTree	ENSGT00740000114855	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00740000114855
HGNC	HGNC:13884	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13884
HOGENOM	HOG000236364	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236364&db=HOGENOM6
HOVERGEN	HBG103052	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG103052&db=HOVERGEN
HPA	HPA040312	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA040312
InParanoid	Q9H172	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9H172
IntAct	Q9H172	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9H172*
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR013525	http://www.ebi.ac.uk/interpro/entry/IPR013525
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	64137	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=64137
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:64137	http://www.genome.jp/dbget-bin/www_bget?hsa:64137
KEGG_Orthology	KO:K05680	http://www.genome.jp/dbget-bin/www_bget?KO:K05680
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
MIM	607784	http://www.ncbi.nlm.nih.gov/omim/607784
MINT	MINT-2840344	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-2840344
OMA	APCPTCP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=APCPTCP
OrthoDB	EOG091G050S	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G050S
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PSORT	swissprot:ABCG4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCG4_HUMAN
PSORT-B	swissprot:ABCG4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCG4_HUMAN
PSORT2	swissprot:ABCG4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCG4_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF01061	http://pfam.xfam.org/family/PF01061
PharmGKB	PA24410	http://www.pharmgkb.org/do/serve?objId=PA24410&objCls=Gene
Phobius	swissprot:ABCG4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCG4_HUMAN
PhylomeDB	Q9H172	http://phylomedb.org/?seqid=Q9H172
ProteinModelPortal	Q9H172	http://www.proteinmodelportal.org/query/uniprot/Q9H172
PubMed	11606068	http://www.ncbi.nlm.nih.gov/pubmed/11606068
PubMed	11856881	http://www.ncbi.nlm.nih.gov/pubmed/11856881
PubMed	12183068	http://www.ncbi.nlm.nih.gov/pubmed/12183068
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-1369062	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1369062
RefSeq	NP_001135977	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001135977
RefSeq	NP_071452	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_071452
RefSeq	XP_011541254	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011541254
RefSeq	XP_016873610	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016873610
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
STRING	9606.ENSP00000304111	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000304111&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TCDB	3.A.1.204.20	http://www.tcdb.org/search/result.php?tc=3.A.1.204.20
UCSC	uc031yhk	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc031yhk&org=rat
UniGene	Hs.126378	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.126378
UniProtKB	ABCG4_HUMAN	http://www.uniprot.org/uniprot/ABCG4_HUMAN
UniProtKB-AC	Q9H172	http://www.uniprot.org/uniprot/Q9H172
charge	swissprot:ABCG4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCG4_HUMAN
eggNOG	COG1131	http://eggnogapi.embl.de/nog_data/html/tree/COG1131
eggNOG	KOG0061	http://eggnogapi.embl.de/nog_data/html/tree/KOG0061
epestfind	swissprot:ABCG4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCG4_HUMAN
garnier	swissprot:ABCG4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCG4_HUMAN
helixturnhelix	swissprot:ABCG4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCG4_HUMAN
hmoment	swissprot:ABCG4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCG4_HUMAN
iep	swissprot:ABCG4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCG4_HUMAN
inforesidue	swissprot:ABCG4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCG4_HUMAN
neXtProt	NX_Q9H172	http://www.nextprot.org/db/entry/NX_Q9H172
octanol	swissprot:ABCG4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCG4_HUMAN
pepcoil	swissprot:ABCG4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCG4_HUMAN
pepdigest	swissprot:ABCG4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCG4_HUMAN
pepinfo	swissprot:ABCG4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCG4_HUMAN
pepnet	swissprot:ABCG4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCG4_HUMAN
pepstats	swissprot:ABCG4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCG4_HUMAN
pepwheel	swissprot:ABCG4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCG4_HUMAN
pepwindow	swissprot:ABCG4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCG4_HUMAN
sigcleave	swissprot:ABCG4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCG4_HUMAN
## Database	ID	URL or Descriptions
# AltName	STEA1_HUMAN	Six-transmembrane epithelial antigen of prostate 1
# COFACTOR	Name=FAD; Xref=ChEBI:CHEBI	57692; Evidence={ECO:0000250}; 
# Ensembl	ENST00000297205	ENSP00000297205; ENSG00000164647
# ExpressionAtlas	Q9UHE8	baseline and differential
# FUNCTION	STEA1_HUMAN	Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity). {ECO 0000250}. 
# GO_component	GO:0005768	endosome; IBA:GO_Central.
# GO_component	GO:0005886	plasma membrane; TAS:ProtInc.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0005911	cell-cell junction; TAS:ProtInc.
# GO_component	GO:0010008	endosome membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_function	GO:0005215	transporter activity; TAS:ProtInc.
# GO_function	GO:0015267	channel activity; TAS:ProtInc.
# GO_function	GO:0016491	oxidoreductase activity; IEA:UniProtKB-KW.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0006811	ion transport; IEA:UniProtKB-KW.
# GO_process	GO:0055072	iron ion homeostasis; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0042592	homeostatic process
# Genevisible	Q9UHE8	HS
# HGNC	HGNC:11378	STEAP1
# InterPro	IPR013130	Fe3_Rdtase_TM_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko04978	Mineral absorption
# MIM	604415	gene
# Organism	STEA1_HUMAN	Homo sapiens (Human)
# Pfam	PF01794	Ferric_reduct
# Proteomes	UP000005640	Chromosome 7
# RecName	STEA1_HUMAN	Metalloreductase STEAP1
# RefSeq	NP_036581	NM_012449.2
# SIMILARITY	Belongs to the STEAP family. {ECO	0000305}. 
# SIMILARITY	Contains 1 ferric oxidoreductase domain. {ECO	0000305}. 
# SUBCELLULAR LOCATION	STEA1_HUMAN	Endosome membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# TCDB	5.B.6.1	the transmembrane epithelial antigen protien-3 ferric reductase (steap) family
# TISSUE SPECIFICITY	Ubiquitously expressed. Highly expressed in prostate tumors. {ECO:0000269|PubMed	16609065}. 
# UCSC	uc003ujx	human
# WEB RESOURCE	STEA1_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/STEAP1ID44482ch7q21.html";
# eggNOG	ENOG410IEI2	Eukaryota
# eggNOG	ENOG4111C63	LUCA
BLAST	swissprot:STEA1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:STEA1_HUMAN
BioCyc	ZFISH:ENSG00000164647-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000164647-MONOMER
COXPRESdb	26872	http://coxpresdb.jp/data/gene/26872.shtml
CleanEx	HS_STEAP1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_STEAP1
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1073/pnas.96.25.14523	http://dx.doi.org/10.1073/pnas.96.25.14523
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1083423	http://dx.doi.org/10.1126/science.1083423
DOI	10.1182/blood-2006-02-003681	http://dx.doi.org/10.1182/blood-2006-02-003681
EC_number	EC:1.16.1.-	http://www.genome.jp/dbget-bin/www_bget?EC:1.16.1.-
EMBL	AC004969	http://www.ebi.ac.uk/ena/data/view/AC004969
EMBL	AC005053	http://www.ebi.ac.uk/ena/data/view/AC005053
EMBL	AF186249	http://www.ebi.ac.uk/ena/data/view/AF186249
EMBL	BC011802	http://www.ebi.ac.uk/ena/data/view/BC011802
EMBL	CH236949	http://www.ebi.ac.uk/ena/data/view/CH236949
ENZYME	1.16.1.-	http://enzyme.expasy.org/EC/1.16.1.-
Ensembl	ENST00000297205	http://www.ensembl.org/id/ENST00000297205
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005911	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005911
GO_component	GO:0010008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010008
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0015267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015267
GO_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0055072	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GeneCards	STEAP1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=STEAP1
GeneID	26872	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26872
GeneTree	ENSGT00390000008042	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000008042
HGNC	HGNC:11378	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11378
HOGENOM	HOG000252937	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000252937&db=HOGENOM6
HOVERGEN	HBG062286	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG062286&db=HOVERGEN
HPA	HPA030985	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA030985
InParanoid	Q9UHE8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UHE8
IntAct	Q9UHE8	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9UHE8*
IntEnz	1.16.1	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.16.1
InterPro	IPR013130	http://www.ebi.ac.uk/interpro/entry/IPR013130
Jabion	26872	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=26872
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:26872	http://www.genome.jp/dbget-bin/www_bget?hsa:26872
KEGG_Orthology	KO:K14737	http://www.genome.jp/dbget-bin/www_bget?KO:K14737
KEGG_Pathway	ko04978	http://www.genome.jp/kegg-bin/show_pathway?ko04978
MIM	604415	http://www.ncbi.nlm.nih.gov/omim/604415
OMA	HGWEDVT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HGWEDVT
OrthoDB	EOG091G0F9X	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0F9X
PSORT	swissprot:STEA1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:STEA1_HUMAN
PSORT-B	swissprot:STEA1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:STEA1_HUMAN
PSORT2	swissprot:STEA1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:STEA1_HUMAN
Pfam	PF01794	http://pfam.xfam.org/family/PF01794
PharmGKB	PA36193	http://www.pharmgkb.org/do/serve?objId=PA36193&objCls=Gene
Phobius	swissprot:STEA1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:STEA1_HUMAN
PhylomeDB	Q9UHE8	http://phylomedb.org/?seqid=Q9UHE8
ProteinModelPortal	Q9UHE8	http://www.proteinmodelportal.org/query/uniprot/Q9UHE8
PubMed	10588738	http://www.ncbi.nlm.nih.gov/pubmed/10588738
PubMed	12690205	http://www.ncbi.nlm.nih.gov/pubmed/12690205
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16609065	http://www.ncbi.nlm.nih.gov/pubmed/16609065
RefSeq	NP_036581	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_036581
STRING	9606.ENSP00000297205	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000297205&targetmode=cogs
TCDB	5.B.6.1	http://www.tcdb.org/search/result.php?tc=5.B.6.1
UCSC	uc003ujx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ujx&org=rat
UniGene	Hs.61635	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.61635
UniProtKB	STEA1_HUMAN	http://www.uniprot.org/uniprot/STEA1_HUMAN
UniProtKB-AC	Q9UHE8	http://www.uniprot.org/uniprot/Q9UHE8
charge	swissprot:STEA1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:STEA1_HUMAN
eggNOG	ENOG410IEI2	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IEI2
eggNOG	ENOG4111C63	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111C63
epestfind	swissprot:STEA1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:STEA1_HUMAN
garnier	swissprot:STEA1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:STEA1_HUMAN
helixturnhelix	swissprot:STEA1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:STEA1_HUMAN
hmoment	swissprot:STEA1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:STEA1_HUMAN
iep	swissprot:STEA1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:STEA1_HUMAN
inforesidue	swissprot:STEA1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:STEA1_HUMAN
neXtProt	NX_Q9UHE8	http://www.nextprot.org/db/entry/NX_Q9UHE8
octanol	swissprot:STEA1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:STEA1_HUMAN
pepcoil	swissprot:STEA1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:STEA1_HUMAN
pepdigest	swissprot:STEA1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:STEA1_HUMAN
pepinfo	swissprot:STEA1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:STEA1_HUMAN
pepnet	swissprot:STEA1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:STEA1_HUMAN
pepstats	swissprot:STEA1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:STEA1_HUMAN
pepwheel	swissprot:STEA1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:STEA1_HUMAN
pepwindow	swissprot:STEA1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:STEA1_HUMAN
sigcleave	swissprot:STEA1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:STEA1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	NTCP7_HUMAN	Event=Alternative splicing; Named isoforms=7; Name=1; Synonyms=C; IsoId=Q0GE19-1; Sequence=Displayed; Name=2; Synonyms=A; IsoId=Q0GE19-2; Sequence=VSP_023224; Name=3; IsoId=Q0GE19-3; Sequence=VSP_023219, VSP_023224; Name=4; Synonyms=B; IsoId=Q0GE19-4; Sequence=VSP_023222, VSP_023223; Name=5; IsoId=Q0GE19-5; Sequence=VSP_023220, VSP_023221; Note=No experimental confirmation available.; Name=6; IsoId=Q0GE19-6; Sequence=VSP_023216, VSP_023217; Note=No experimental confirmation available.; Name=7; IsoId=Q0GE19-7; Sequence=VSP_023215, VSP_023218; Note=No experimental confirmation available.; 
# AltName	NTCP7_HUMAN	Na(+)/bile acid cotransporter 7
# AltName	NTCP7_HUMAN	Solute carrier family 10 member 7
# BioGrid	123863	11
# CCDS	CCDS34073	-. [Q0GE19-2]
# CCDS	CCDS3768	-. [Q0GE19-5]
# CCDS	CCDS75198	-. [Q0GE19-1]
# CCDS	CCDS82962	-. [Q0GE19-7]
# CCDS	CCDS82963	-. [Q0GE19-3]
# CCDS	CCDS82964	-. [Q0GE19-6]
# ChiTaRS	SLC10A7	human
# Ensembl	ENST00000335472	ENSP00000334594; ENSG00000120519. [Q0GE19-2]
# Ensembl	ENST00000394059	ENSP00000377623; ENSG00000120519. [Q0GE19-5]
# Ensembl	ENST00000432059	ENSP00000411297; ENSG00000120519. [Q0GE19-3]
# Ensembl	ENST00000502607	ENSP00000422577; ENSG00000120519. [Q0GE19-6]
# Ensembl	ENST00000507030	ENSP00000421275; ENSG00000120519. [Q0GE19-1]
# Ensembl	ENST00000511374	ENSP00000421603; ENSG00000120519. [Q0GE19-7]
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_process	GO:0006814	sodium ion transport; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q0GE19	HS
# HGNC	HGNC:23088	SLC10A7
# InterPro	IPR016833	Put_Na-Bile_cotransptr
# KEGG_Brite	ko02001	Solute carrier family
# MIM	611459	gene
# Organism	NTCP7_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR18640	PTHR18640
# PIRSF	PIRSF026166	UCP026166
# Pfam	PF13593	SBF_like
# Proteomes	UP000005640	Chromosome 4
# RecName	NTCP7_HUMAN	Sodium/bile acid cotransporter 7
# RefSeq	NP_001025169	NM_001029998.5. [Q0GE19-2]
# RefSeq	NP_001287771	NM_001300842.2. [Q0GE19-1]
# RefSeq	NP_001304745	NM_001317816.1. [Q0GE19-3]
# RefSeq	NP_001304746	NM_001317817.1. [Q0GE19-7]
# RefSeq	NP_001304747	NM_001317818.1. [Q0GE19-6]
# RefSeq	NP_115504	NM_032128.4. [Q0GE19-5]
# RefSeq	XP_016864181	XM_017008692.1. [Q0GE19-7]
# SEQUENCE CAUTION	Sequence=BAC11571.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the unknown BART superfamily-1 (UBS1) (TC 2.A.93) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	NTCP7_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	2.A.28.3:the bile acid	na(+) symporter (bass) family
# UCSC	uc003ikr	human. [Q0GE19-1]
# eggNOG	COG0385	LUCA
# eggNOG	KOG4821	Eukaryota
BLAST	swissprot:NTCP7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NTCP7_HUMAN
COG	COG0385	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0385
COXPRESdb	84068	http://coxpresdb.jp/data/gene/84068.shtml
DOI	10.1007/s10528-005-1509-y	http://dx.doi.org/10.1007/s10528-005-1509-y
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1101/gr.GR1547R	http://dx.doi.org/10.1101/gr.GR1547R
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AK075364	http://www.ebi.ac.uk/ena/data/view/AK075364
EMBL	AL136728	http://www.ebi.ac.uk/ena/data/view/AL136728
EMBL	AY346324	http://www.ebi.ac.uk/ena/data/view/AY346324
EMBL	BC023288	http://www.ebi.ac.uk/ena/data/view/BC023288
EMBL	BC063471	http://www.ebi.ac.uk/ena/data/view/BC063471
EMBL	BC120970	http://www.ebi.ac.uk/ena/data/view/BC120970
EMBL	BC120971	http://www.ebi.ac.uk/ena/data/view/BC120971
EMBL	BC127626	http://www.ebi.ac.uk/ena/data/view/BC127626
EMBL	BC127627	http://www.ebi.ac.uk/ena/data/view/BC127627
EMBL	BC148252	http://www.ebi.ac.uk/ena/data/view/BC148252
EMBL	BC150308	http://www.ebi.ac.uk/ena/data/view/BC150308
EMBL	CH471056	http://www.ebi.ac.uk/ena/data/view/CH471056
EMBL	CR933647	http://www.ebi.ac.uk/ena/data/view/CR933647
EMBL	DQ122860	http://www.ebi.ac.uk/ena/data/view/DQ122860
EMBL	DQ122861	http://www.ebi.ac.uk/ena/data/view/DQ122861
EMBL	DQ871036	http://www.ebi.ac.uk/ena/data/view/DQ871036
Ensembl	ENST00000335472	http://www.ensembl.org/id/ENST00000335472
Ensembl	ENST00000394059	http://www.ensembl.org/id/ENST00000394059
Ensembl	ENST00000432059	http://www.ensembl.org/id/ENST00000432059
Ensembl	ENST00000502607	http://www.ensembl.org/id/ENST00000502607
Ensembl	ENST00000507030	http://www.ensembl.org/id/ENST00000507030
Ensembl	ENST00000511374	http://www.ensembl.org/id/ENST00000511374
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC10A7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC10A7
GeneID	84068	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84068
GeneTree	ENSGT00390000011932	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000011932
H-InvDB	HIX0004549	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0004549
HGNC	HGNC:23088	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:23088
HOVERGEN	HBG082064	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG082064&db=HOVERGEN
HPA	HPA039996	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA039996
HPA	HPA057906	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA057906
InParanoid	Q0GE19	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q0GE19
InterPro	IPR016833	http://www.ebi.ac.uk/interpro/entry/IPR016833
Jabion	84068	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=84068
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:84068	http://www.genome.jp/dbget-bin/www_bget?hsa:84068
KEGG_Orthology	KO:K14347	http://www.genome.jp/dbget-bin/www_bget?KO:K14347
MIM	611459	http://www.ncbi.nlm.nih.gov/omim/611459
MINT	MINT-4721825	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4721825
OMA	FFFYGLK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FFFYGLK
OrthoDB	EOG091G0GR7	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0GR7
PANTHER	PTHR18640	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18640
PSORT	swissprot:NTCP7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NTCP7_HUMAN
PSORT-B	swissprot:NTCP7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NTCP7_HUMAN
PSORT2	swissprot:NTCP7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NTCP7_HUMAN
Pfam	PF13593	http://pfam.xfam.org/family/PF13593
PharmGKB	PA162403478	http://www.pharmgkb.org/do/serve?objId=PA162403478&objCls=Gene
Phobius	swissprot:NTCP7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NTCP7_HUMAN
PhylomeDB	Q0GE19	http://phylomedb.org/?seqid=Q0GE19
ProteinModelPortal	Q0GE19	http://www.proteinmodelportal.org/query/uniprot/Q0GE19
PubMed	11230166	http://www.ncbi.nlm.nih.gov/pubmed/11230166
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15932064	http://www.ncbi.nlm.nih.gov/pubmed/15932064
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
RefSeq	NP_001025169	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001025169
RefSeq	NP_001287771	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001287771
RefSeq	NP_001304745	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001304745
RefSeq	NP_001304746	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001304746
RefSeq	NP_001304747	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001304747
RefSeq	NP_115504	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_115504
RefSeq	XP_016864181	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016864181
STRING	9606.ENSP00000334594	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000334594&targetmode=cogs
STRING	COG0385	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0385&targetmode=cogs
TCDB	2.A.28.3	http://www.tcdb.org/search/result.php?tc=2.A.28.3
UCSC	uc003ikr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ikr&org=rat
UniGene	Hs.659209	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.659209
UniProtKB	NTCP7_HUMAN	http://www.uniprot.org/uniprot/NTCP7_HUMAN
UniProtKB-AC	Q0GE19	http://www.uniprot.org/uniprot/Q0GE19
charge	swissprot:NTCP7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NTCP7_HUMAN
eggNOG	COG0385	http://eggnogapi.embl.de/nog_data/html/tree/COG0385
eggNOG	KOG4821	http://eggnogapi.embl.de/nog_data/html/tree/KOG4821
epestfind	swissprot:NTCP7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NTCP7_HUMAN
garnier	swissprot:NTCP7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NTCP7_HUMAN
helixturnhelix	swissprot:NTCP7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NTCP7_HUMAN
hmoment	swissprot:NTCP7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NTCP7_HUMAN
iep	swissprot:NTCP7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NTCP7_HUMAN
inforesidue	swissprot:NTCP7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NTCP7_HUMAN
neXtProt	NX_Q0GE19	http://www.nextprot.org/db/entry/NX_Q0GE19
octanol	swissprot:NTCP7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NTCP7_HUMAN
pepcoil	swissprot:NTCP7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NTCP7_HUMAN
pepdigest	swissprot:NTCP7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NTCP7_HUMAN
pepinfo	swissprot:NTCP7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NTCP7_HUMAN
pepnet	swissprot:NTCP7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NTCP7_HUMAN
pepstats	swissprot:NTCP7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NTCP7_HUMAN
pepwheel	swissprot:NTCP7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NTCP7_HUMAN
pepwindow	swissprot:NTCP7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NTCP7_HUMAN
sigcleave	swissprot:NTCP7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NTCP7_HUMAN
## Database	ID	URL or Descriptions
# AltName	NIPA3_HUMAN	NIPA-like protein 1
# AltName	NIPA3_HUMAN	Non-imprinted in Prader-Willi/Angelman syndrome region protein 3
# ChiTaRS	NIPAL1	human
# Ensembl	ENST00000295461	ENSP00000295461; ENSG00000163293
# ExpressionAtlas	Q6NVV3	baseline and differential
# FUNCTION	NIPA3_HUMAN	Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). {ECO 0000250}. 
# GO_component	GO:0016020	membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015095	magnesium ion transmembrane transporter activity; IEA:InterPro.
# GO_process	GO:0015693	magnesium ion transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	Q6NVV3	HS
# HGNC	HGNC:27194	NIPAL1
# InterPro	IPR008521	Mg_trans_NIPA
# Organism	NIPA3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12570	PTHR12570
# Pfam	PF05653	Mg_trans_NIPA
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-5223345	Miscellaneous transport and binding events
# RecName	NIPA3_HUMAN	Magnesium transporter NIPA3
# RefSeq	NP_997213	NM_207330.2
# SIMILARITY	Belongs to the NIPA family. {ECO	0000305}.
# SUBCELLULAR LOCATION	NIPA3_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# UCSC	uc003gxw	human
# eggNOG	ENOG410XNR8	LUCA
# eggNOG	KOG2922	Eukaryota
BLAST	swissprot:NIPA3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NIPA3_HUMAN
COXPRESdb	152519	http://coxpresdb.jp/data/gene/152519.shtml
CleanEx	HS_NPAL1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_NPAL1
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AK095299	http://www.ebi.ac.uk/ena/data/view/AK095299
EMBL	BC067881	http://www.ebi.ac.uk/ena/data/view/BC067881
EMBL	CR749484	http://www.ebi.ac.uk/ena/data/view/CR749484
Ensembl	ENST00000295461	http://www.ensembl.org/id/ENST00000295461
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015095
GO_process	GO:0015693	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015693
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	NIPAL1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=NIPAL1
GeneID	152519	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=152519
GeneTree	ENSGT00550000074395	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074395
HGNC	HGNC:27194	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:27194
HOGENOM	HOG000203962	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000203962&db=HOGENOM6
HPA	HPA036765	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA036765
InParanoid	Q6NVV3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6NVV3
InterPro	IPR008521	http://www.ebi.ac.uk/interpro/entry/IPR008521
Jabion	152519	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=152519
KEGG_Gene	hsa:152519	http://www.genome.jp/dbget-bin/www_bget?hsa:152519
OMA	EPCQEGY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EPCQEGY
OrthoDB	EOG091G0M8A	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0M8A
PANTHER	PTHR12570	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12570
PSORT	swissprot:NIPA3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NIPA3_HUMAN
PSORT-B	swissprot:NIPA3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NIPA3_HUMAN
PSORT2	swissprot:NIPA3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NIPA3_HUMAN
Pfam	PF05653	http://pfam.xfam.org/family/PF05653
PharmGKB	PA164723925	http://www.pharmgkb.org/do/serve?objId=PA164723925&objCls=Gene
Phobius	swissprot:NIPA3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NIPA3_HUMAN
PhylomeDB	Q6NVV3	http://phylomedb.org/?seqid=Q6NVV3
ProteinModelPortal	Q6NVV3	http://www.proteinmodelportal.org/query/uniprot/Q6NVV3
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
Reactome	R-HSA-5223345	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5223345
RefSeq	NP_997213	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_997213
STRING	9606.ENSP00000295461	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000295461&targetmode=cogs
UCSC	uc003gxw	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003gxw&org=rat
UniGene	Hs.134190	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.134190
UniProtKB	NIPA3_HUMAN	http://www.uniprot.org/uniprot/NIPA3_HUMAN
UniProtKB-AC	Q6NVV3	http://www.uniprot.org/uniprot/Q6NVV3
charge	swissprot:NIPA3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NIPA3_HUMAN
eggNOG	ENOG410XNR8	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNR8
eggNOG	KOG2922	http://eggnogapi.embl.de/nog_data/html/tree/KOG2922
epestfind	swissprot:NIPA3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NIPA3_HUMAN
garnier	swissprot:NIPA3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NIPA3_HUMAN
helixturnhelix	swissprot:NIPA3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NIPA3_HUMAN
hmoment	swissprot:NIPA3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NIPA3_HUMAN
iep	swissprot:NIPA3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NIPA3_HUMAN
inforesidue	swissprot:NIPA3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NIPA3_HUMAN
neXtProt	NX_Q6NVV3	http://www.nextprot.org/db/entry/NX_Q6NVV3
octanol	swissprot:NIPA3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NIPA3_HUMAN
pepcoil	swissprot:NIPA3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NIPA3_HUMAN
pepdigest	swissprot:NIPA3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NIPA3_HUMAN
pepinfo	swissprot:NIPA3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NIPA3_HUMAN
pepnet	swissprot:NIPA3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NIPA3_HUMAN
pepstats	swissprot:NIPA3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NIPA3_HUMAN
pepwheel	swissprot:NIPA3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NIPA3_HUMAN
pepwindow	swissprot:NIPA3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NIPA3_HUMAN
sigcleave	swissprot:NIPA3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NIPA3_HUMAN
## Database	ID	URL or Descriptions
# AltName	CLD16_HUMAN	Paracellin-1
# DISEASE	CLD16_HUMAN	Hypomagnesemia 3 (HOMG3) [MIM 248250]  A progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis. Recurrent urinary tract infections and kidney stones are often observed. In spite of hypercalciuria, patients do not show hypocalcemia. {ECO 0000269|PubMed 10390358, ECO 0000269|PubMed 10878661, ECO 0000269|PubMed 11518780}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000264734	ENSP00000264734; ENSG00000113946
# ExpressionAtlas	Q9Y5I7	baseline and differential
# FUNCTION	CLD16_HUMAN	Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors. 
# GO_component	GO:0005886	plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005923	bicellular tight junction; ISS:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005198	structural molecule activity; IEA:InterPro.
# GO_function	GO:0015095	magnesium ion transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0042802	identical protein binding; ISS:UniProtKB.
# GO_process	GO:0006875	cellular metal ion homeostasis; TAS:ProtInc.
# GO_process	GO:0007588	excretion; TAS:ProtInc.
# GO_process	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0005198	structural molecule activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0007155	cell adhesion
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# Genevisible	Q9Y5I7	HS
# HGNC	HGNC:2037	CLDN16
# INTERACTION	CLD16_HUMAN	Q9Z0S3 Cldn14 (xeno); NbExp=3; IntAct=EBI-7774981, EBI-7774956; 
# IntAct	Q9Y5I7	2
# InterPro	IPR003927	Claudin16
# InterPro	IPR004031	PMP22/EMP/MP20/Claudin
# InterPro	IPR006187	Claudin
# InterPro	IPR017974	Claudin_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04516	 Cell adhesion molecules and their ligands
# KEGG_Disease	H01210	[Inherited metabolic disease] Hypomagnesemia
# KEGG_Pathway	ko04514	Cell adhesion molecules (CAMs)
# KEGG_Pathway	ko04530	Tight junction
# KEGG_Pathway	ko04670	Leukocyte transendothelial migration
# KEGG_Pathway	ko05160	Hepatitis C
# MIM	248250	phenotype
# MIM	603959	gene
# Organism	CLD16_HUMAN	Homo sapiens (Human)
# Orphanet	31043	Familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis without severe ocular involvement
# PANTHER	PTHR12002	PTHR12002
# PANTHER	PTHR12002:SF56	PTHR12002:SF56
# PRINTS	PR01447	CLAUDIN16
# PROSITE	PS01346	CLAUDIN
# Pfam	PF00822	PMP22_Claudin
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-420029	Tight junction interactions
# RecName	CLD16_HUMAN	Claudin-16
# RefSeq	NP_006571	NM_006580.3
# SIMILARITY	Belongs to the claudin family. {ECO	0000305}.
# SUBCELLULAR LOCATION	CLD16_HUMAN	Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. 
# TCDB	1.H.1.1	the claudin tight junction (claudin1) family
# TISSUE SPECIFICITY	CLD16_HUMAN	Kidney-specific, including the thick ascending limb of Henle (TAL). 
# UCSC	uc003fsi	human
# eggNOG	ENOG410IEIE	Eukaryota
# eggNOG	ENOG410XP0E	LUCA
BLAST	swissprot:CLD16_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CLD16_HUMAN
BioCyc	ZFISH:ENSG00000113946-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000113946-MONOMER
COXPRESdb	10686	http://coxpresdb.jp/data/gene/10686.shtml
CleanEx	HS_CLDN16	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CLDN16
DIP	DIP-48951N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48951N
DOI	10.1038/sj.ejhg.5200475	http://dx.doi.org/10.1038/sj.ejhg.5200475
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.285.5424.103	http://dx.doi.org/10.1126/science.285.5424.103
EMBL	AF152101	http://www.ebi.ac.uk/ena/data/view/AF152101
EMBL	BC069662	http://www.ebi.ac.uk/ena/data/view/BC069662
EMBL	BC069682	http://www.ebi.ac.uk/ena/data/view/BC069682
EMBL	BC069759	http://www.ebi.ac.uk/ena/data/view/BC069759
EMBL	BC069777	http://www.ebi.ac.uk/ena/data/view/BC069777
Ensembl	ENST00000264734	http://www.ensembl.org/id/ENST00000264734
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005923	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005923
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198
GO_function	GO:0015095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015095
GO_function	GO:0042802	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802
GO_process	GO:0006875	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006875
GO_process	GO:0007588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007588
GO_process	GO:0016338	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016338
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0005198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GeneCards	CLDN16	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CLDN16
GeneID	10686	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10686
GeneTree	ENSGT00730000111162	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00730000111162
HGNC	HGNC:2037	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2037
HOGENOM	HOG000111787	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000111787&db=HOGENOM6
HOVERGEN	HBG050987	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050987&db=HOVERGEN
HPA	HPA056020	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA056020
InParanoid	Q9Y5I7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y5I7
IntAct	Q9Y5I7	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9Y5I7*
InterPro	IPR003927	http://www.ebi.ac.uk/interpro/entry/IPR003927
InterPro	IPR004031	http://www.ebi.ac.uk/interpro/entry/IPR004031
InterPro	IPR006187	http://www.ebi.ac.uk/interpro/entry/IPR006187
InterPro	IPR017974	http://www.ebi.ac.uk/interpro/entry/IPR017974
Jabion	10686	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10686
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04516	http://www.genome.jp/dbget-bin/www_bget?ko04516
KEGG_Disease	H01210	http://www.genome.jp/dbget-bin/www_bget?H01210
KEGG_Gene	hsa:10686	http://www.genome.jp/dbget-bin/www_bget?hsa:10686
KEGG_Orthology	KO:K06087	http://www.genome.jp/dbget-bin/www_bget?KO:K06087
KEGG_Pathway	ko04514	http://www.genome.jp/kegg-bin/show_pathway?ko04514
KEGG_Pathway	ko04530	http://www.genome.jp/kegg-bin/show_pathway?ko04530
KEGG_Pathway	ko04670	http://www.genome.jp/kegg-bin/show_pathway?ko04670
KEGG_Pathway	ko05160	http://www.genome.jp/kegg-bin/show_pathway?ko05160
MIM	248250	http://www.ncbi.nlm.nih.gov/omim/248250
MIM	603959	http://www.ncbi.nlm.nih.gov/omim/603959
MINT	MINT-8387823	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8387823
OMA	YAVDTRV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YAVDTRV
Orphanet	31043	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=31043
OrthoDB	EOG091G0MX2	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0MX2
PANTHER	PTHR12002	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12002
PANTHER	PTHR12002:SF56	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12002:SF56
PRINTS	PR01447	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01447
PROSITE	PS01346	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01346
PSORT	swissprot:CLD16_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CLD16_HUMAN
PSORT-B	swissprot:CLD16_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CLD16_HUMAN
PSORT2	swissprot:CLD16_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CLD16_HUMAN
Pfam	PF00822	http://pfam.xfam.org/family/PF00822
PharmGKB	PA26563	http://www.pharmgkb.org/do/serve?objId=PA26563&objCls=Gene
Phobius	swissprot:CLD16_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CLD16_HUMAN
PhylomeDB	Q9Y5I7	http://phylomedb.org/?seqid=Q9Y5I7
ProteinModelPortal	Q9Y5I7	http://www.proteinmodelportal.org/query/uniprot/Q9Y5I7
PubMed	10390358	http://www.ncbi.nlm.nih.gov/pubmed/10390358
PubMed	10878661	http://www.ncbi.nlm.nih.gov/pubmed/10878661
PubMed	11518780	http://www.ncbi.nlm.nih.gov/pubmed/11518780
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-420029	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-420029
RefSeq	NP_006571	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006571
STRING	9606.ENSP00000264734	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000264734&targetmode=cogs
TCDB	1.H.1.1	http://www.tcdb.org/search/result.php?tc=1.H.1.1
UCSC	uc003fsi	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003fsi&org=rat
UniGene	Hs.251391	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.251391
UniProtKB	CLD16_HUMAN	http://www.uniprot.org/uniprot/CLD16_HUMAN
UniProtKB-AC	Q9Y5I7	http://www.uniprot.org/uniprot/Q9Y5I7
charge	swissprot:CLD16_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CLD16_HUMAN
eggNOG	ENOG410IEIE	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IEIE
eggNOG	ENOG410XP0E	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XP0E
epestfind	swissprot:CLD16_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CLD16_HUMAN
garnier	swissprot:CLD16_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CLD16_HUMAN
helixturnhelix	swissprot:CLD16_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLD16_HUMAN
hmoment	swissprot:CLD16_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CLD16_HUMAN
iep	swissprot:CLD16_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CLD16_HUMAN
inforesidue	swissprot:CLD16_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CLD16_HUMAN
neXtProt	NX_Q9Y5I7	http://www.nextprot.org/db/entry/NX_Q9Y5I7
octanol	swissprot:CLD16_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CLD16_HUMAN
pepcoil	swissprot:CLD16_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CLD16_HUMAN
pepdigest	swissprot:CLD16_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CLD16_HUMAN
pepinfo	swissprot:CLD16_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CLD16_HUMAN
pepnet	swissprot:CLD16_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CLD16_HUMAN
pepstats	swissprot:CLD16_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CLD16_HUMAN
pepwheel	swissprot:CLD16_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CLD16_HUMAN
pepwindow	swissprot:CLD16_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CLD16_HUMAN
sigcleave	swissprot:CLD16_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CLD16_HUMAN
## Database	ID	URL or Descriptions
# AltName	GBRR3_HUMAN	GABA(A) receptor subunit rho-3
# AltName	GBRR3_HUMAN	GABA(C) receptor
# DrugBank	DB00231	Temazepam
# DrugBank	DB00546	Adinazolam
# DrugBank	DB00683	Midazolam
# DrugBank	DB00690	Flurazepam
# DrugBank	DB00801	Halazepam
# DrugBank	DB00829	Diazepam
# DrugBank	DB00842	Oxazepam
# DrugBank	DB00897	Triazolam
# DrugBank	DB01215	Estazolam
# DrugBank	DB01558	Bromazepam
# DrugBank	DB01559	Clotiazepam
# DrugBank	DB01567	Fludiazepam
# DrugBank	DB01588	Prazepam
# DrugBank	DB01589	Quazepam
# DrugBank	DB01594	Cinolazepam
# DrugBank	DB01595	Nitrazepam
# Ensembl	ENST00000472788	ENSP00000420790; ENSG00000183185
# Ensembl	ENST00000621172	ENSP00000481321; ENSG00000183185
# FUNCTION	GBRR3_HUMAN	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:1902711	GABA-A receptor complex; IBA:GO_Central.
# GO_function	GO:0004890	GABA-A receptor activity; NAS:UniProtKB.
# GO_function	GO:0005230	extracellular ligand-gated ion channel activity; IEA:InterPro.
# GO_function	GO:0005254	chloride channel activity; IEA:UniProtKB-KW.
# GO_process	GO:0007214	gamma-aminobutyric acid signaling pathway; NAS:UniProtKB.
# GO_process	GO:0007268	chemical synaptic transmission; NAS:UniProtKB.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.70.170.10	-; 1.
# Genevisible	A8MPY1	HS
# HGNC	HGNC:17969	GABRR3
# InterPro	IPR006028	GABAA/Glycine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04727	GABAergic synapse
# KEGG_Pathway	ko05032	Morphine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# Organism	GBRR3_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR18945	PTHR18945; 2
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00253	GABAARECEPTR
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-975298	Ligand-gated ion channel transport
# Reactome	R-HSA-977442	GABA A (rho) receptor activation
# RecName	GBRR3_HUMAN	Gamma-aminobutyric acid receptor subunit rho-3
# RefSeq	NP_001099050	NM_001105580.2
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR3 sub-subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	GBRR3_HUMAN	Cell junction, synapse, postsynaptic cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUBUNIT	Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Forms a ternary complex with SQSTM1 and PRKCZ (By similarity). {ECO	0000250}. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TIGRFAMs	TIGR00860	LIC
# UCSC	uc021xbo	human
# eggNOG	ENOG410XPWH	LUCA
# eggNOG	KOG3643	Eukaryota
BLAST	swissprot:GBRR3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GBRR3_HUMAN
BioCyc	ZFISH:G66-31893-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31893-MONOMER
COXPRESdb	200959	http://coxpresdb.jp/data/gene/200959.shtml
CleanEx	HS_GABRR3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GABRR3
DOI	10.1016/S0167-4781(99)00167-0	http://dx.doi.org/10.1016/S0167-4781(99)00167-0
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DrugBank	DB00231	http://www.drugbank.ca/drugs/DB00231
DrugBank	DB00546	http://www.drugbank.ca/drugs/DB00546
DrugBank	DB00683	http://www.drugbank.ca/drugs/DB00683
DrugBank	DB00690	http://www.drugbank.ca/drugs/DB00690
DrugBank	DB00801	http://www.drugbank.ca/drugs/DB00801
DrugBank	DB00829	http://www.drugbank.ca/drugs/DB00829
DrugBank	DB00842	http://www.drugbank.ca/drugs/DB00842
DrugBank	DB00897	http://www.drugbank.ca/drugs/DB00897
DrugBank	DB01215	http://www.drugbank.ca/drugs/DB01215
DrugBank	DB01558	http://www.drugbank.ca/drugs/DB01558
DrugBank	DB01559	http://www.drugbank.ca/drugs/DB01559
DrugBank	DB01567	http://www.drugbank.ca/drugs/DB01567
DrugBank	DB01588	http://www.drugbank.ca/drugs/DB01588
DrugBank	DB01589	http://www.drugbank.ca/drugs/DB01589
DrugBank	DB01594	http://www.drugbank.ca/drugs/DB01594
DrugBank	DB01595	http://www.drugbank.ca/drugs/DB01595
EMBL	AC026100	http://www.ebi.ac.uk/ena/data/view/AC026100
EMBL	Y18994	http://www.ebi.ac.uk/ena/data/view/Y18994
Ensembl	ENST00000472788	http://www.ensembl.org/id/ENST00000472788
Ensembl	ENST00000621172	http://www.ensembl.org/id/ENST00000621172
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_component	GO:1902711	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902711
GO_function	GO:0004890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004890
GO_function	GO:0005230	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005230
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_process	GO:0007214	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007214
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	GABRR3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GABRR3
GeneID	200959	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=200959
GeneTree	ENSGT00760000118821	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118821
HGNC	HGNC:17969	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17969
HOVERGEN	HBG051707	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051707&db=HOVERGEN
InParanoid	A8MPY1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=A8MPY1
InterPro	IPR006028	http://www.ebi.ac.uk/interpro/entry/IPR006028
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
Jabion	200959	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=200959
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:200959	http://www.genome.jp/dbget-bin/www_bget?hsa:200959
KEGG_Orthology	KO:K05190	http://www.genome.jp/dbget-bin/www_bget?KO:K05190
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
KEGG_Pathway	ko05032	http://www.genome.jp/kegg-bin/show_pathway?ko05032
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
OMA	MDFTMTF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MDFTMTF
OrthoDB	EOG091G0805	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0805
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00253	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00253
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:GBRR3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GBRR3_HUMAN
PSORT-B	swissprot:GBRR3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GBRR3_HUMAN
PSORT2	swissprot:GBRR3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GBRR3_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA134952133	http://www.pharmgkb.org/do/serve?objId=PA134952133&objCls=Gene
Phobius	swissprot:GBRR3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GBRR3_HUMAN
PhylomeDB	A8MPY1	http://phylomedb.org/?seqid=A8MPY1
ProteinModelPortal	A8MPY1	http://www.proteinmodelportal.org/query/uniprot/A8MPY1
PubMed	10542332	http://www.ncbi.nlm.nih.gov/pubmed/10542332
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
Reactome	R-HSA-975298	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-975298
Reactome	R-HSA-977442	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-977442
RefSeq	NP_001099050	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001099050
STRING	9606.ENSP00000471569	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000471569&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc021xbo	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc021xbo&org=rat
UniGene	Hs.534578	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.534578
UniProtKB	GBRR3_HUMAN	http://www.uniprot.org/uniprot/GBRR3_HUMAN
UniProtKB-AC	A8MPY1	http://www.uniprot.org/uniprot/A8MPY1
charge	swissprot:GBRR3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GBRR3_HUMAN
eggNOG	ENOG410XPWH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPWH
eggNOG	KOG3643	http://eggnogapi.embl.de/nog_data/html/tree/KOG3643
epestfind	swissprot:GBRR3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GBRR3_HUMAN
garnier	swissprot:GBRR3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GBRR3_HUMAN
helixturnhelix	swissprot:GBRR3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GBRR3_HUMAN
hmoment	swissprot:GBRR3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GBRR3_HUMAN
iep	swissprot:GBRR3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GBRR3_HUMAN
inforesidue	swissprot:GBRR3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GBRR3_HUMAN
neXtProt	NX_A8MPY1	http://www.nextprot.org/db/entry/NX_A8MPY1
octanol	swissprot:GBRR3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GBRR3_HUMAN
pepcoil	swissprot:GBRR3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GBRR3_HUMAN
pepdigest	swissprot:GBRR3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GBRR3_HUMAN
pepinfo	swissprot:GBRR3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GBRR3_HUMAN
pepnet	swissprot:GBRR3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GBRR3_HUMAN
pepstats	swissprot:GBRR3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GBRR3_HUMAN
pepwheel	swissprot:GBRR3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GBRR3_HUMAN
pepwindow	swissprot:GBRR3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GBRR3_HUMAN
sigcleave	swissprot:GBRR3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GBRR3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCIP2_HUMAN	Event=Alternative splicing; Named isoforms=9; Name=1; Synonyms=KChIP2a, KChIP2b, KCHIP2.4, KCHIP2L; IsoId=Q9NS61-1; Sequence=Displayed; Name=2; Synonyms=3, KChIP2.1, KChIP2b; IsoId=Q9NS61-2; Sequence=VSP_015052; Name=3; Synonyms=2, KChIP2.2, KChIP2c, KCHIP2S; IsoId=Q9NS61-3; Sequence=VSP_015051; Name=4; IsoId=Q9NS61-4; Sequence=VSP_015050; Name=5; IsoId=Q9NS61-5; Sequence=VSP_015051, VSP_015056; Name=6; Synonyms=KCHIP4.2; IsoId=Q9NS61-6; Sequence=VSP_015053; Name=7; IsoId=Q9NS61-7; Sequence=VSP_015051, VSP_015055; Name=8; Synonyms=KCHIP2.6; IsoId=Q9NS61-8; Sequence=VSP_015049, VSP_015054; Name=9; Synonyms=KCHIP2.5; IsoId=Q9NS61-9; Sequence=VSP_015051, VSP_015057, VSP_015058; 
# AltName	KCIP2_HUMAN	A-type potassium channel modulatory protein 2
# AltName	KCIP2_HUMAN	Cardiac voltage-gated potassium channel modulatory subunit
# AltName	KCIP2_HUMAN	Potassium channel-interacting protein 2
# BioGrid	119043	11
# CCDS	CCDS41562	-. [Q9NS61-2]
# CCDS	CCDS7521	-. [Q9NS61-6]
# CCDS	CCDS7522	-. [Q9NS61-1]
# CCDS	CCDS7523	-. [Q9NS61-7]
# CCDS	CCDS7524	-. [Q9NS61-3]
# CCDS	CCDS7525	-. [Q9NS61-4]
# CCDS	CCDS7526	-. [Q9NS61-9]
# CDD	cd00051	EFh; 2
# ChiTaRS	KCNIP2	human
# Ensembl	ENST00000239117	ENSP00000239117; ENSG00000120049. [Q9NS61-9]
# Ensembl	ENST00000343195	ENSP00000344169; ENSG00000120049. [Q9NS61-3]
# Ensembl	ENST00000348850	ENSP00000239118; ENSG00000120049. [Q9NS61-4]
# Ensembl	ENST00000353068	ENSP00000341624; ENSG00000120049. [Q9NS61-7]
# Ensembl	ENST00000356640	ENSP00000349055; ENSG00000120049. [Q9NS61-1]
# Ensembl	ENST00000358038	ENSP00000350733; ENSG00000120049. [Q9NS61-2]
# Ensembl	ENST00000434163	ENSP00000411679; ENSG00000120049. [Q9NS61-8]
# Ensembl	ENST00000461105	ENSP00000420040; ENSG00000120049. [Q9NS61-6]
# ExpressionAtlas	Q9NS61	baseline and differential
# FUNCTION	KCIP2_HUMAN	Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart (By similarity). {ECO 0000250|UniProtKB Q9JJ69, ECO 0000269|PubMed 10676964, ECO 0000269|PubMed 11287421, ECO 0000269|PubMed 11684073, ECO 0000269|PubMed 12297301, ECO 0000269|PubMed 12829703, ECO 0000269|PubMed 14623880}. 
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008076	voltage-gated potassium channel complex; NAS:UniProtKB.
# GO_function	GO:0005250	A-type (transient outward) potassium channel activity; TAS:UniProtKB.
# GO_function	GO:0005509	calcium ion binding; TAS:UniProtKB.
# GO_function	GO:0015459	potassium channel regulator activity; IDA:BHF-UCL.
# GO_function	GO:0044325	ion channel binding; IPI:BHF-UCL.
# GO_function	GO:0046923	ER retention sequence binding; NAS:UniProtKB.
# GO_function	GO:0047485	protein N-terminus binding; IPI:UniProtKB.
# GO_process	GO:0005513	detection of calcium ion; TAS:ProtInc.
# GO_process	GO:0006813	potassium ion transport; TAS:UniProtKB.
# GO_process	GO:0006936	muscle contraction; NAS:UniProtKB.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0007268	chemical synaptic transmission; NAS:UniProtKB.
# GO_process	GO:0008016	regulation of heart contraction; TAS:UniProtKB.
# GO_process	GO:0045163	clustering of voltage-gated potassium channels; IDA:UniProtKB.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:0071435	potassium ion export; IDA:BHF-UCL.
# GO_process	GO:0071805	potassium ion transmembrane transport; IDA:BHF-UCL.
# GO_process	GO:0086009	membrane repolarization; IDA:BHF-UCL.
# GO_process	GO:1901379	regulation of potassium ion transmembrane transport; ISS:UniProtKB.
# GO_process	GO:2001257	regulation of cation channel activity; TAS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# GOslim_process	GO:0061024	membrane organization
# Gene3D	1.10.238.10	-; 1.
# Genevisible	Q9NS61	HS
# HGNC	HGNC:15522	KCNIP2
# INTERACTION	KCIP2_HUMAN	Q9NZV8 KCND2; NbExp=3; IntAct=EBI-1052975, EBI-1646745; Q9NZI2 KCNIP1; NbExp=4; IntAct=EBI-1053010, EBI-2120635; 
# IntAct	Q9NS61	2
# InterPro	IPR002048	EF_hand_dom
# InterPro	IPR011992	EF-hand-dom_pair
# InterPro	IPR018247	EF_Hand_1_Ca_BS
# InterPro	IPR028846	Recoverin
# InterPro	IPR029532	KCNIP2
# MIM	604661	gene
# Organism	KCIP2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR23055	PTHR23055
# PANTHER	PTHR23055:SF65	PTHR23055:SF65
# PROSITE	PS00018	EF_HAND_1; 3
# PROSITE	PS50222	EF_HAND_2; 3
# PTM	KCIP2_HUMAN	Palmitoylated. Palmitoylation enhances association with the plasma membrane. {ECO 0000250|UniProtKB Q9JM59}. 
# Pfam	PF13499	EF-hand_7
# Pfam	PF13833	EF-hand_8
# Proteomes	UP000005640	Chromosome 10
# Reactome	R-HSA-5576894	Phase 1 - inactivation of fast Na+ channels
# RecName	KCIP2_HUMAN	Kv channel-interacting protein 2
# RefSeq	NP_055406	NM_014591.4. [Q9NS61-6]
# RefSeq	NP_775283	NM_173191.2. [Q9NS61-1]
# RefSeq	NP_775284	NM_173192.2. [Q9NS61-2]
# RefSeq	NP_775285	NM_173193.2. [Q9NS61-7]
# RefSeq	NP_775286	NM_173194.2. [Q9NS61-4]
# RefSeq	NP_775287	NM_173195.2. [Q9NS61-3]
# RefSeq	NP_775289	NM_173197.2. [Q9NS61-9]
# SIMILARITY	Belongs to the recoverin family. {ECO	0000305}. 
# SIMILARITY	Contains 4 EF-hand domains. {ECO:0000255|PROSITE- ProRule	PRU00448}.
# SMART	SM00054	EFh; 3
# SUBCELLULAR LOCATION	KCIP2_HUMAN	Isoform 1  Cell membrane {ECO 0000250|UniProtKB Q9JM59}; Lipid-anchor {ECO 0000250|UniProtKB Q9JM59}. Note=Detected on lipid rafts (By similarity). {ECO 0000250|UniProtKB Q9JM59}. 
# SUBCELLULAR LOCATION	KCIP2_HUMAN	Isoform 2  Cell membrane {ECO 0000250|UniProtKB Q9JM59}; Lipid-anchor {ECO 0000250|UniProtKB Q9JM59}. 
# SUBCELLULAR LOCATION	KCIP2_HUMAN	Isoform 6  Cell membrane {ECO 0000250|UniProtKB Q9JM59}; Lipid-anchor {ECO 0000250|UniProtKB Q9JM59}. 
# SUBUNIT	KCIP2_HUMAN	Component of heteromultimeric potassium channels. Identified in potassium channel complexes containing KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10 (By similarity). The KCND2-KCNIP2 channel complex contains four KCND2 and four KCNIP2 subunits (PubMed 14623880, PubMed 14980201). Interacts with KCND2 (PubMed 10676964, PubMed 14623880, PubMed 14980201). Isoform 1 and isoform 3 interact with KCND3 isoform 1. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2. At least isoform 2 and isoform 3 can self- associate to form homodimers and homotetramers. Isoform 3 interacts with KCNIP1 in a calcium-dependent manner. {ECO 0000250|UniProtKB Q9JJ69, ECO 0000269|PubMed 10676964, ECO 0000269|PubMed 11287421, ECO 0000269|PubMed 12297301, ECO 0000269|PubMed 14623880, ECO 0000269|PubMed 14980201, ECO 0000269|PubMed 15356203, ECO 0000269|PubMed 15358149}. 
# SUPFAM	SSF47473	SSF47473
# TISSUE SPECIFICITY	KCIP2_HUMAN	Expressed in brain. Colocalizes with KCND2 in excitatory neurons including cortical and hippocampal CA1 pyramidal cells. Isoform 3 is expressed in heart and in umbilical vein endothelial cells. Not expressed in fetal heart. {ECO 0000269|PubMed 11263977, ECO 0000269|PubMed 11684073, ECO 0000269|PubMed 15356203}. 
# UCSC	uc001ktz	human. [Q9NS61-1]
BLAST	swissprot:KCIP2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCIP2_HUMAN
COXPRESdb	30819	http://coxpresdb.jp/data/gene/30819.shtml
DOI	10.1006/bbrc.2001.4558	http://dx.doi.org/10.1006/bbrc.2001.4558
DOI	10.1016/S0008-6363(01)00374-1	http://dx.doi.org/10.1016/S0008-6363(01)00374-1
DOI	10.1016/S0014-5793(02)03296-9	http://dx.doi.org/10.1016/S0014-5793(02)03296-9
DOI	10.1016/S0896-6273(04)00050-9	http://dx.doi.org/10.1016/S0896-6273(04)00050-9
DOI	10.1016/j.bbrc.2004.07.006	http://dx.doi.org/10.1016/j.bbrc.2004.07.006
DOI	10.1016/j.ygeno.2005.07.001	http://dx.doi.org/10.1016/j.ygeno.2005.07.001
DOI	10.1038/35000592	http://dx.doi.org/10.1038/35000592
DOI	10.1038/nature02462	http://dx.doi.org/10.1038/nature02462
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M101320200	http://dx.doi.org/10.1074/jbc.M101320200
DOI	10.1074/jbc.M306142200	http://dx.doi.org/10.1074/jbc.M306142200
DOI	10.1074/jbc.M311332200	http://dx.doi.org/10.1074/jbc.M311332200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1101/gr.GR1547R	http://dx.doi.org/10.1101/gr.GR1547R
DOI	10.1523/JNEUROSCI.0776-04.2004	http://dx.doi.org/10.1523/JNEUROSCI.0776-04.2004
EMBL	AB044584	http://www.ebi.ac.uk/ena/data/view/AB044584
EMBL	AB044585	http://www.ebi.ac.uk/ena/data/view/AB044585
EMBL	AC010789	http://www.ebi.ac.uk/ena/data/view/AC010789
EMBL	AF199598	http://www.ebi.ac.uk/ena/data/view/AF199598
EMBL	AF295076	http://www.ebi.ac.uk/ena/data/view/AF295076
EMBL	AF295530	http://www.ebi.ac.uk/ena/data/view/AF295530
EMBL	AF347114	http://www.ebi.ac.uk/ena/data/view/AF347114
EMBL	AF367018	http://www.ebi.ac.uk/ena/data/view/AF367018
EMBL	AF367019	http://www.ebi.ac.uk/ena/data/view/AF367019
EMBL	AF367020	http://www.ebi.ac.uk/ena/data/view/AF367020
EMBL	AF367021	http://www.ebi.ac.uk/ena/data/view/AF367021
EMBL	AJ276317	http://www.ebi.ac.uk/ena/data/view/AJ276317
EMBL	AK027347	http://www.ebi.ac.uk/ena/data/view/AK027347
EMBL	AK315042	http://www.ebi.ac.uk/ena/data/view/AK315042
EMBL	AL136722	http://www.ebi.ac.uk/ena/data/view/AL136722
EMBL	AY026328	http://www.ebi.ac.uk/ena/data/view/AY026328
EMBL	AY026329	http://www.ebi.ac.uk/ena/data/view/AY026329
EMBL	AY026330	http://www.ebi.ac.uk/ena/data/view/AY026330
EMBL	AY026331	http://www.ebi.ac.uk/ena/data/view/AY026331
EMBL	AY302141	http://www.ebi.ac.uk/ena/data/view/AY302141
EMBL	BC034685	http://www.ebi.ac.uk/ena/data/view/BC034685
EMBL	CH471066	http://www.ebi.ac.uk/ena/data/view/CH471066
EMBL	DQ148480	http://www.ebi.ac.uk/ena/data/view/DQ148480
EMBL	DQ148481	http://www.ebi.ac.uk/ena/data/view/DQ148481
EMBL	DQ148483	http://www.ebi.ac.uk/ena/data/view/DQ148483
Ensembl	ENST00000239117	http://www.ensembl.org/id/ENST00000239117
Ensembl	ENST00000343195	http://www.ensembl.org/id/ENST00000343195
Ensembl	ENST00000348850	http://www.ensembl.org/id/ENST00000348850
Ensembl	ENST00000353068	http://www.ensembl.org/id/ENST00000353068
Ensembl	ENST00000356640	http://www.ensembl.org/id/ENST00000356640
Ensembl	ENST00000358038	http://www.ensembl.org/id/ENST00000358038
Ensembl	ENST00000434163	http://www.ensembl.org/id/ENST00000434163
Ensembl	ENST00000461105	http://www.ensembl.org/id/ENST00000461105
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_function	GO:0005250	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005250
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0015459	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015459
GO_function	GO:0044325	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044325
GO_function	GO:0046923	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046923
GO_function	GO:0047485	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047485
GO_process	GO:0005513	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005513
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0006936	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006936
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0008016	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008016
GO_process	GO:0045163	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045163
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:0071435	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071435
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GO_process	GO:0086009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086009
GO_process	GO:1901379	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901379
GO_process	GO:2001257	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001257
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
Gene3D	1.10.238.10	http://www.cathdb.info/version/latest/superfamily/1.10.238.10
GeneCards	KCNIP2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNIP2
GeneID	30819	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=30819
GeneTree	ENSGT00760000118820	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118820
HGNC	HGNC:15522	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:15522
HOVERGEN	HBG108179	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108179&db=HOVERGEN
InParanoid	Q9NS61	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NS61
IntAct	Q9NS61	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NS61*
InterPro	IPR002048	http://www.ebi.ac.uk/interpro/entry/IPR002048
InterPro	IPR011992	http://www.ebi.ac.uk/interpro/entry/IPR011992
InterPro	IPR018247	http://www.ebi.ac.uk/interpro/entry/IPR018247
InterPro	IPR028846	http://www.ebi.ac.uk/interpro/entry/IPR028846
InterPro	IPR029532	http://www.ebi.ac.uk/interpro/entry/IPR029532
Jabion	30819	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=30819
KEGG_Gene	hsa:30819	http://www.genome.jp/dbget-bin/www_bget?hsa:30819
MIM	604661	http://www.ncbi.nlm.nih.gov/omim/604661
MINT	MINT-4712078	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4712078
OMA	MNRCPRR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MNRCPRR
OrthoDB	EOG091G11T4	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G11T4
PANTHER	PTHR23055	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23055
PANTHER	PTHR23055:SF65	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23055:SF65
PROSITE	PS00018	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00018
PROSITE	PS50222	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50222
PSORT	swissprot:KCIP2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCIP2_HUMAN
PSORT-B	swissprot:KCIP2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCIP2_HUMAN
PSORT2	swissprot:KCIP2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCIP2_HUMAN
Pfam	PF13499	http://pfam.xfam.org/family/PF13499
Pfam	PF13833	http://pfam.xfam.org/family/PF13833
PharmGKB	PA30042	http://www.pharmgkb.org/do/serve?objId=PA30042&objCls=Gene
Phobius	swissprot:KCIP2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCIP2_HUMAN
ProteinModelPortal	Q9NS61	http://www.proteinmodelportal.org/query/uniprot/Q9NS61
PubMed	10676964	http://www.ncbi.nlm.nih.gov/pubmed/10676964
PubMed	11230166	http://www.ncbi.nlm.nih.gov/pubmed/11230166
PubMed	11263977	http://www.ncbi.nlm.nih.gov/pubmed/11263977
PubMed	11287421	http://www.ncbi.nlm.nih.gov/pubmed/11287421
PubMed	11684073	http://www.ncbi.nlm.nih.gov/pubmed/11684073
PubMed	12297301	http://www.ncbi.nlm.nih.gov/pubmed/12297301
PubMed	12829703	http://www.ncbi.nlm.nih.gov/pubmed/12829703
PubMed	14623880	http://www.ncbi.nlm.nih.gov/pubmed/14623880
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	14980201	http://www.ncbi.nlm.nih.gov/pubmed/14980201
PubMed	15164054	http://www.ncbi.nlm.nih.gov/pubmed/15164054
PubMed	15356203	http://www.ncbi.nlm.nih.gov/pubmed/15356203
PubMed	15358149	http://www.ncbi.nlm.nih.gov/pubmed/15358149
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16112838	http://www.ncbi.nlm.nih.gov/pubmed/16112838
Reactome	R-HSA-5576894	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576894
RefSeq	NP_055406	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055406
RefSeq	NP_775283	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_775283
RefSeq	NP_775284	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_775284
RefSeq	NP_775285	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_775285
RefSeq	NP_775286	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_775286
RefSeq	NP_775287	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_775287
RefSeq	NP_775289	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_775289
SMART	SM00054	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00054
SMR	Q9NS61	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9NS61
SUPFAM	SSF47473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47473
UCSC	uc001ktz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001ktz&org=rat
UniGene	Hs.97044	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.97044
UniProtKB	KCIP2_HUMAN	http://www.uniprot.org/uniprot/KCIP2_HUMAN
UniProtKB-AC	Q9NS61	http://www.uniprot.org/uniprot/Q9NS61
charge	swissprot:KCIP2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCIP2_HUMAN
epestfind	swissprot:KCIP2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCIP2_HUMAN
garnier	swissprot:KCIP2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCIP2_HUMAN
helixturnhelix	swissprot:KCIP2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCIP2_HUMAN
hmoment	swissprot:KCIP2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCIP2_HUMAN
iep	swissprot:KCIP2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCIP2_HUMAN
inforesidue	swissprot:KCIP2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCIP2_HUMAN
neXtProt	NX_Q9NS61	http://www.nextprot.org/db/entry/NX_Q9NS61
octanol	swissprot:KCIP2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCIP2_HUMAN
pepcoil	swissprot:KCIP2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCIP2_HUMAN
pepdigest	swissprot:KCIP2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCIP2_HUMAN
pepinfo	swissprot:KCIP2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCIP2_HUMAN
pepnet	swissprot:KCIP2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCIP2_HUMAN
pepstats	swissprot:KCIP2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCIP2_HUMAN
pepwheel	swissprot:KCIP2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCIP2_HUMAN
pepwindow	swissprot:KCIP2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCIP2_HUMAN
sigcleave	swissprot:KCIP2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCIP2_HUMAN
## Database	ID	URL or Descriptions
# AltName	COX5A_HUMAN	Cytochrome c oxidase polypeptide Va
# BioGrid	114778	56
# CDD	cd00923	Cyt_c_Oxidase_Va
# ChiTaRS	COX5A	human
# DrugBank	DB02659	Cholic Acid
# Ensembl	ENST00000322347	ENSP00000317780; ENSG00000178741
# Ensembl	ENST00000564811	ENSP00000456386; ENSG00000178741
# ExpressionAtlas	P20674	baseline and differential
# FUNCTION	COX5A_HUMAN	This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. 
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0005751	mitochondrial respiratory chain complex IV; IBA:GO_Central.
# GO_component	GO:0043209	myelin sheath; IEA:Ensembl.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0004129	cytochrome-c oxidase activity; TAS:ProtInc.
# GO_function	GO:0009055	electron carrier activity; TAS:UniProtKB.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# Gene3D	1.25.40.40	-; 1.
# Genevisible	P20674	HS
# HGNC	HGNC:2267	COX5A
# INTERACTION	COX5A_HUMAN	Q96B26 EXOSC8; NbExp=3; IntAct=EBI-715032, EBI-371922; Q15323 KRT31; NbExp=3; IntAct=EBI-715032, EBI-948001; Q6A162 KRT40; NbExp=3; IntAct=EBI-715032, EBI-10171697; 
# IntAct	P20674	26
# InterPro	IPR003204	Cyt_c_oxidase_su5A/6
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	603773	gene
# Organism	COX5A_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR14200	PTHR14200
# PIR	JT0342	OTHU5A
# Pfam	PF02284	COX5A
# Proteomes	UP000005640	Chromosome 15
# Reactome	R-HSA-5628897	TP53 Regulates Metabolic Genes
# Reactome	R-HSA-611105	Respiratory electron transport
# RecName	COX5A_HUMAN	Cytochrome c oxidase subunit 5A, mitochondrial
# RefSeq	NP_004246	NM_004255.3
# SIMILARITY	Belongs to the cytochrome c oxidase subunit 5A family. {ECO	0000305}.
# SUBCELLULAR LOCATION	COX5A_HUMAN	Mitochondrion inner membrane. 
# SUPFAM	SSF48479	SSF48479
# TCDB	3.D.4.11	the proton-translocating cytochrome oxidase (cox) superfamily
# UCSC	uc002azi	human
# eggNOG	ENOG4111MPD	LUCA
# eggNOG	KOG4077	Eukaryota
BLAST	swissprot:COX5A_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:COX5A_HUMAN
BioCyc	ZFISH:HS11312-MONOMER	http://biocyc.org/getid?id=ZFISH:HS11312-MONOMER
COXPRESdb	9377	http://coxpresdb.jp/data/gene/9377.shtml
CleanEx	HS_COX5A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_COX5A
DOI	10.1002/elps.11501401181	http://dx.doi.org/10.1002/elps.11501401181
DOI	10.1002/elps.11501601192	http://dx.doi.org/10.1002/elps.11501601192
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/0378-1119(88)90435-0	http://dx.doi.org/10.1016/0378-1119(88)90435-0
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature04601	http://dx.doi.org/10.1038/nature04601
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2148-8-8	http://dx.doi.org/10.1186/1471-2148-8-8
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DrugBank	DB02659	http://www.drugbank.ca/drugs/DB02659
EMBL	AC125435	http://www.ebi.ac.uk/ena/data/view/AC125435
EMBL	BC024240	http://www.ebi.ac.uk/ena/data/view/BC024240
EMBL	CH471136	http://www.ebi.ac.uk/ena/data/view/CH471136
EMBL	CR407649	http://www.ebi.ac.uk/ena/data/view/CR407649
EMBL	DQ987236	http://www.ebi.ac.uk/ena/data/view/DQ987236
EMBL	DQ987237	http://www.ebi.ac.uk/ena/data/view/DQ987237
EMBL	M22760	http://www.ebi.ac.uk/ena/data/view/M22760
Ensembl	ENST00000322347	http://www.ensembl.org/id/ENST00000322347
Ensembl	ENST00000564811	http://www.ensembl.org/id/ENST00000564811
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005751	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005751
GO_component	GO:0043209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043209
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0004129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004129
GO_function	GO:0009055	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006123	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006123
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
Gene3D	1.25.40.40	http://www.cathdb.info/version/latest/superfamily/1.25.40.40
GeneCards	COX5A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=COX5A
GeneID	9377	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9377
GeneTree	ENSGT00390000001424	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000001424
HGNC	HGNC:2267	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2267
HOGENOM	HOG000160656	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000160656&db=HOGENOM6
HOVERGEN	HBG051088	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051088&db=HOVERGEN
HPA	HPA027526	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA027526
InParanoid	P20674	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P20674
IntAct	P20674	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P20674*
InterPro	IPR003204	http://www.ebi.ac.uk/interpro/entry/IPR003204
Jabion	9377	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9377
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Gene	hsa:9377	http://www.genome.jp/dbget-bin/www_bget?hsa:9377
KEGG_Orthology	KO:K02264	http://www.genome.jp/dbget-bin/www_bget?KO:K02264
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	603773	http://www.ncbi.nlm.nih.gov/omim/603773
MINT	MINT-1386385	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1386385
OMA	SARCYSH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SARCYSH
PANTHER	PTHR14200	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14200
PSORT	swissprot:COX5A_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:COX5A_HUMAN
PSORT-B	swissprot:COX5A_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:COX5A_HUMAN
PSORT2	swissprot:COX5A_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:COX5A_HUMAN
Pfam	PF02284	http://pfam.xfam.org/family/PF02284
PharmGKB	PA26784	http://www.pharmgkb.org/do/serve?objId=PA26784&objCls=Gene
Phobius	swissprot:COX5A_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:COX5A_HUMAN
PhylomeDB	P20674	http://phylomedb.org/?seqid=P20674
ProteinModelPortal	P20674	http://www.proteinmodelportal.org/query/uniprot/P20674
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16572171	http://www.ncbi.nlm.nih.gov/pubmed/16572171
PubMed	18197981	http://www.ncbi.nlm.nih.gov/pubmed/18197981
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	2853101	http://www.ncbi.nlm.nih.gov/pubmed/2853101
PubMed	7498159	http://www.ncbi.nlm.nih.gov/pubmed/7498159
PubMed	8313870	http://www.ncbi.nlm.nih.gov/pubmed/8313870
Reactome	R-HSA-5628897	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5628897
Reactome	R-HSA-611105	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-611105
RefSeq	NP_004246	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004246
SMR	P20674	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P20674
STRING	9606.ENSP00000317780	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000317780&targetmode=cogs
SUPFAM	SSF48479	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48479
SWISS-2DPAGE	P20674	http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P20674
TCDB	3.D.4.11	http://www.tcdb.org/search/result.php?tc=3.D.4.11
UCSC	uc002azi	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002azi&org=rat
UniGene	Hs.401903	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.401903
UniProtKB	COX5A_HUMAN	http://www.uniprot.org/uniprot/COX5A_HUMAN
UniProtKB-AC	P20674	http://www.uniprot.org/uniprot/P20674
charge	swissprot:COX5A_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:COX5A_HUMAN
eggNOG	ENOG4111MPD	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111MPD
eggNOG	KOG4077	http://eggnogapi.embl.de/nog_data/html/tree/KOG4077
epestfind	swissprot:COX5A_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:COX5A_HUMAN
garnier	swissprot:COX5A_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:COX5A_HUMAN
helixturnhelix	swissprot:COX5A_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:COX5A_HUMAN
hmoment	swissprot:COX5A_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:COX5A_HUMAN
iep	swissprot:COX5A_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:COX5A_HUMAN
inforesidue	swissprot:COX5A_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:COX5A_HUMAN
neXtProt	NX_P20674	http://www.nextprot.org/db/entry/NX_P20674
octanol	swissprot:COX5A_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:COX5A_HUMAN
pepcoil	swissprot:COX5A_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:COX5A_HUMAN
pepdigest	swissprot:COX5A_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:COX5A_HUMAN
pepinfo	swissprot:COX5A_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:COX5A_HUMAN
pepnet	swissprot:COX5A_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:COX5A_HUMAN
pepstats	swissprot:COX5A_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:COX5A_HUMAN
pepwheel	swissprot:COX5A_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:COX5A_HUMAN
pepwindow	swissprot:COX5A_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:COX5A_HUMAN
sigcleave	swissprot:COX5A_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:COX5A_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GLRA3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=Alpha-3L; IsoId=O75311-1; Sequence=Displayed; Name=Alpha-3K; IsoId=O75311-2; Sequence=VSP_000084; 
# CCDS	CCDS3822	-. [O75311-1]
# CCDS	CCDS43283	-. [O75311-2]
# DOMAIN	GLRA3_HUMAN	The N-terminal domain carries structural determinants essential for agonist and antagonist binding. The channel pore is formed by pentameric assembly of the second transmembrane domain from all five subunits (PubMed 26416729). The cytoplasmic loop is an important determinant of channel inactivation kinetics. {ECO 0000269|PubMed 26416729, ECO 0000305}. 
# DrugBank	DB00145	Glycine
# DrugBank	DB00431	Lindane
# DrugBank	DB00602	Ivermectin
# Ensembl	ENST00000274093	ENSP00000274093; ENSG00000145451. [O75311-1]
# Ensembl	ENST00000340217	ENSP00000345284; ENSG00000145451. [O75311-2]
# FUNCTION	GLRA3_HUMAN	Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed 9677400, PubMed 26416729). Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to ethanol (By similarity). {ECO 0000250|UniProtKB P24524, ECO 0000250|UniProtKB Q91XP5, ECO 0000269|PubMed 26416729, ECO 0000269|PubMed 9677400}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016935	glycine-gated chloride channel complex; IDA:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030425	dendrite; IEA:UniProtKB-SubCell.
# GO_component	GO:0043204	perikaryon; IEA:UniProtKB-SubCell.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0016594	glycine binding; IEA:InterPro.
# GO_function	GO:0016934	extracellular-glycine-gated chloride channel activity; IDA:UniProtKB.
# GO_function	GO:0022852	glycine-gated chloride ion channel activity; IDA:UniProtKB.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0007218	neuropeptide signaling pathway; IBA:GO_Central.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0043200	response to amino acid; IBA:GO_Central.
# GO_process	GO:0051260	protein homooligomerization; IDA:UniProtKB.
# GO_process	GO:0060012	synaptic transmission, glycinergic; IBA:GO_Central.
# GO_process	GO:1902476	chloride transmembrane transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.70.170.10	-; 1.
# Genevisible	O75311	HS
# HGNC	HGNC:4328	GLRA3
# InterPro	IPR006028	GABAA/Glycine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR008127	Glycine_rcpt_A
# InterPro	IPR008130	Glycine_rcpt_A3
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# MIM	600421	gene
# MISCELLANEOUS	The alpha subunit binds strychnine. {ECO:0000269|PubMed	26416729}. 
# Organism	GLRA3_HUMAN	Homo sapiens (Human)
# PDB	5CFB	X-ray; 3.04 A; A/B/C/D/E=34-342, A/B/C/D/E=419-460
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00253	GABAARECEPTR
# PRINTS	PR01673	GLYRALPHA
# PRINTS	PR01676	GLYRALPHA3
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# PTM	GLRA3_HUMAN	Phosphorylated by PKA; this causes down-regulation of channel activity. {ECO 0000250|UniProtKB P24524}. 
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-975298	Ligand-gated ion channel transport
# RecName	GLRA3_HUMAN	Glycine receptor subunit alpha-3
# RefSeq	NP_001036008	NM_001042543.2. [O75311-2]
# RefSeq	NP_006520	NM_006529.3. [O75311-1]
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA3 sub- subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	GLRA3_HUMAN	Cell junction, synapse, postsynaptic cell membrane {ECO 0000250|UniProtKB P24524}; Multi-pass membrane protein {ECO 0000305}. Perikaryon {ECO 0000250|UniProtKB P24524}. Cell projection, dendrite {ECO 0000250|UniProtKB P24524}. Cell junction, synapse {ECO 0000250|UniProtKB P24524}. Cell membrane {ECO 0000269|PubMed 26416729, ECO 0000269|PubMed 9677400}; Multi- pass membrane protein {ECO 0000269|PubMed 26416729}. Note=Partially colocalizes with GPHN that is known to mediate receptor clustering at postsynaptic membranes. {ECO 0000250|UniProtKB P24524}. 
# SUBUNIT	GLRA3_HUMAN	Homopentamer (in vitro) (PubMed 26416729). Heteropentamer composed of GLRA3 and GLRB. Both homopentamers and heteropentamers form functional ion channels, but their characteristics are subtly different (By similarity). {ECO 0000250|UniProtKB P24524, ECO 0000269|PubMed 26416729}. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TCDB	1.A.9.3	the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family
# TIGRFAMs	TIGR00860	LIC
# TISSUE SPECIFICITY	Widely distributed throughout the central nervous system. {ECO:0000269|PubMed	9677400}. 
# UCSC	uc003ity	human. [O75311-1]
# eggNOG	ENOG410XPWH	LUCA
# eggNOG	KOG3643	Eukaryota
BLAST	swissprot:GLRA3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GLRA3_HUMAN
BioCyc	ZFISH:ENSG00000145451-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000145451-MONOMER
COXPRESdb	8001	http://coxpresdb.jp/data/gene/8001.shtml
CleanEx	HS_GLRA3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GLRA3
DIP	DIP-61773N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-61773N
DOI	10.1038/nature14972	http://dx.doi.org/10.1038/nature14972
DOI	10.1074/jbc.273.31.19708	http://dx.doi.org/10.1074/jbc.273.31.19708
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00145	http://www.drugbank.ca/drugs/DB00145
DrugBank	DB00431	http://www.drugbank.ca/drugs/DB00431
DrugBank	DB00602	http://www.drugbank.ca/drugs/DB00602
EMBL	AF017715	http://www.ebi.ac.uk/ena/data/view/AF017715
EMBL	AF017716	http://www.ebi.ac.uk/ena/data/view/AF017716
EMBL	AF017717	http://www.ebi.ac.uk/ena/data/view/AF017717
EMBL	AF017718	http://www.ebi.ac.uk/ena/data/view/AF017718
EMBL	AF017719	http://www.ebi.ac.uk/ena/data/view/AF017719
EMBL	AF017720	http://www.ebi.ac.uk/ena/data/view/AF017720
EMBL	AF017721	http://www.ebi.ac.uk/ena/data/view/AF017721
EMBL	AF017722	http://www.ebi.ac.uk/ena/data/view/AF017722
EMBL	AF017723	http://www.ebi.ac.uk/ena/data/view/AF017723
EMBL	AF017724	http://www.ebi.ac.uk/ena/data/view/AF017724
EMBL	BC036086	http://www.ebi.ac.uk/ena/data/view/BC036086
EMBL	CH471056	http://www.ebi.ac.uk/ena/data/view/CH471056
EMBL	CH471056	http://www.ebi.ac.uk/ena/data/view/CH471056
EMBL	U93917	http://www.ebi.ac.uk/ena/data/view/U93917
Ensembl	ENST00000274093	http://www.ensembl.org/id/ENST00000274093
Ensembl	ENST00000340217	http://www.ensembl.org/id/ENST00000340217
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016935	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016935
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0043204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043204
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0016594	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016594
GO_function	GO:0016934	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016934
GO_function	GO:0022852	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022852
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0007218	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007218
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0043200	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043200
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:0060012	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060012
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	GLRA3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GLRA3
GeneID	8001	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8001
GeneTree	ENSGT00760000118821	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118821
HGNC	HGNC:4328	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4328
HOGENOM	HOG000231336	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231336&db=HOGENOM6
HOVERGEN	HBG051707	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051707&db=HOVERGEN
InParanoid	O75311	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O75311
InterPro	IPR006028	http://www.ebi.ac.uk/interpro/entry/IPR006028
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR008127	http://www.ebi.ac.uk/interpro/entry/IPR008127
InterPro	IPR008130	http://www.ebi.ac.uk/interpro/entry/IPR008130
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
Jabion	8001	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=8001
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:8001	http://www.genome.jp/dbget-bin/www_bget?hsa:8001
KEGG_Orthology	KO:K05195	http://www.genome.jp/dbget-bin/www_bget?KO:K05195
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
MIM	600421	http://www.ncbi.nlm.nih.gov/omim/600421
OMA	PKNSDEM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PKNSDEM
OrthoDB	EOG091G0805	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0805
PDB	5CFB	http://www.ebi.ac.uk/pdbe-srv/view/entry/5CFB
PDBsum	5CFB	http://www.ebi.ac.uk/pdbsum/5CFB
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00253	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00253
PRINTS	PR01673	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01673
PRINTS	PR01676	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01676
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:GLRA3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GLRA3_HUMAN
PSORT-B	swissprot:GLRA3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GLRA3_HUMAN
PSORT2	swissprot:GLRA3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GLRA3_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA28729	http://www.pharmgkb.org/do/serve?objId=PA28729&objCls=Gene
Phobius	swissprot:GLRA3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GLRA3_HUMAN
PhylomeDB	O75311	http://phylomedb.org/?seqid=O75311
ProteinModelPortal	O75311	http://www.proteinmodelportal.org/query/uniprot/O75311
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	26416729	http://www.ncbi.nlm.nih.gov/pubmed/26416729
PubMed	9677400	http://www.ncbi.nlm.nih.gov/pubmed/9677400
Reactome	R-HSA-975298	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-975298
RefSeq	NP_001036008	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001036008
RefSeq	NP_006520	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006520
SMR	O75311	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O75311
STRING	9606.ENSP00000274093	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000274093&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TCDB	1.A.9.3	http://www.tcdb.org/search/result.php?tc=1.A.9.3
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc003ity	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ity&org=rat
UniGene	Hs.413099	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.413099
UniProtKB	GLRA3_HUMAN	http://www.uniprot.org/uniprot/GLRA3_HUMAN
UniProtKB-AC	O75311	http://www.uniprot.org/uniprot/O75311
charge	swissprot:GLRA3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GLRA3_HUMAN
eggNOG	ENOG410XPWH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPWH
eggNOG	KOG3643	http://eggnogapi.embl.de/nog_data/html/tree/KOG3643
epestfind	swissprot:GLRA3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GLRA3_HUMAN
garnier	swissprot:GLRA3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GLRA3_HUMAN
helixturnhelix	swissprot:GLRA3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLRA3_HUMAN
hmoment	swissprot:GLRA3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GLRA3_HUMAN
iep	swissprot:GLRA3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GLRA3_HUMAN
inforesidue	swissprot:GLRA3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GLRA3_HUMAN
neXtProt	NX_O75311	http://www.nextprot.org/db/entry/NX_O75311
octanol	swissprot:GLRA3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GLRA3_HUMAN
pepcoil	swissprot:GLRA3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GLRA3_HUMAN
pepdigest	swissprot:GLRA3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GLRA3_HUMAN
pepinfo	swissprot:GLRA3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GLRA3_HUMAN
pepnet	swissprot:GLRA3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GLRA3_HUMAN
pepstats	swissprot:GLRA3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GLRA3_HUMAN
pepwheel	swissprot:GLRA3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GLRA3_HUMAN
pepwindow	swissprot:GLRA3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GLRA3_HUMAN
sigcleave	swissprot:GLRA3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GLRA3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	XPO2_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=A; IsoId=P55060-1; Sequence=Displayed; Name=2; IsoId=P55060-2; Sequence=VSP_001222, VSP_001223; Name=3; IsoId=P55060-3; Sequence=VSP_001224, VSP_001225; Name=4; IsoId=P55060-4; Sequence=VSP_047203; Note=No experimental confirmation available.; 
# AltName	XPO2_HUMAN	Cellular apoptosis susceptibility protein
# AltName	XPO2_HUMAN	Chromosome segregation 1-like protein
# AltName	XPO2_HUMAN	Importin-alpha re-exporter
# BioGrid	107821	109
# CCDS	CCDS13412	-. [P55060-1]
# CCDS	CCDS58773	-. [P55060-4]
# ChiTaRS	CSE1L	human
# Ensembl	ENST00000262982	ENSP00000262982; ENSG00000124207. [P55060-1]
# Ensembl	ENST00000396192	ENSP00000379495; ENSG00000124207. [P55060-4]
# FUNCTION	XPO2_HUMAN	Export receptor for importin-alpha. Mediates importin- alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO 0000269|PubMed 9323134}. 
# GO_component	GO:0005634	nucleus; TAS:ProtInc.
# GO_component	GO:0005635	nuclear envelope; IBA:GO_Central.
# GO_component	GO:0005654	nucleoplasm; IDA:HPA.
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0005829	cytosol; IBA:GO_Central.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005049	nuclear export signal receptor activity; TAS:ProtInc.
# GO_process	GO:0006606	protein import into nucleus; IBA:GO_Central.
# GO_process	GO:0006915	apoptotic process; TAS:ProtInc.
# GO_process	GO:0008283	cell proliferation; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005635	nuclear envelope
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# GOslim_process	GO:0008219	cell death
# GOslim_process	GO:0008283	cell proliferation
# Gene3D	1.25.10.10	-; 2.
# Genevisible	P55060	HS
# HGNC	HGNC:2431	CSE1L
# INTERACTION	XPO2_HUMAN	P04637 TP53; NbExp=5; IntAct=EBI-286709, EBI-366083; 
# IntAct	P55060	36
# InterPro	IPR001494	Importin-beta_N
# InterPro	IPR005043	CAS_CSE1_C
# InterPro	IPR011989	ARM-like
# InterPro	IPR013713	Cse1
# InterPro	IPR016024	ARM-type_fold
# MIM	601342	gene
# Organism	XPO2_HUMAN	Homo sapiens (Human)
# PIR	I39166	I39166
# PROSITE	PS50166	IMPORTIN_B_NT
# Pfam	PF03378	CAS_CSE1
# Pfam	PF03810	IBN_N
# Pfam	PF08506	Cse1
# Proteomes	UP000005640	Chromosome 20
# RecName	XPO2_HUMAN	Exportin-2
# RefSeq	NP_001243064	NM_001256135.1. [P55060-4]
# RefSeq	NP_001307	NM_001316.3. [P55060-1]
# RefSeq	XP_011526901	XM_011528599.2. [P55060-3]
# SIMILARITY	Belongs to the XPO2/CSE1 family. {ECO	0000305}. 
# SIMILARITY	Contains 1 importin N-terminal domain. {ECO:0000255|PROSITE-ProRule	PRU00115}. 
# SMART	SM00913	IBN_N
# SUBCELLULAR LOCATION	XPO2_HUMAN	Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. 
# SUBUNIT	Found in a complex with CSE1L/XPO2, Ran and KPNA2. Binds with high affinity to importin-alpha only in the presence of RanGTP. The complex is dissociated by the combined action of RanBP1 and RanGAP1. {ECO:0000269|PubMed	9323134}. 
# SUPFAM	SSF48371	SSF48371
# TCDB	1.I.1.1	the nuclear pore complex (npc) family
# TISSUE SPECIFICITY	XPO2_HUMAN	Highly expressed in proliferating cells. 
# UCSC	uc002xty	human. [P55060-1]
# WEB RESOURCE	XPO2_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/CSE1LID40159ch20q13.html";
# eggNOG	COG5657	LUCA
# eggNOG	KOG1992	Eukaryota
BLAST	swissprot:XPO2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:XPO2_HUMAN
BioCyc	ZFISH:ENSG00000124207-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000124207-MONOMER
COXPRESdb	1434	http://coxpresdb.jp/data/gene/1434.shtml
CleanEx	HS_CSE1L	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CSE1L
DIP	DIP-32573N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-32573N
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/geno.1998.5700	http://dx.doi.org/10.1006/geno.1998.5700
DOI	10.1006/mcbr.2001.0303	http://dx.doi.org/10.1006/mcbr.2001.0303
DOI	10.1016/S0092-8674(00)80372-4	http://dx.doi.org/10.1016/S0092-8674(00)80372-4
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/414865a	http://dx.doi.org/10.1038/414865a
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1073/pnas.92.22.10427	http://dx.doi.org/10.1073/pnas.92.22.10427
DOI	10.1074/mcp.M111.015131	http://dx.doi.org/10.1074/mcp.M111.015131
DOI	10.1083/jcb.143.2.309	http://dx.doi.org/10.1083/jcb.143.2.309
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF053640	http://www.ebi.ac.uk/ena/data/view/AF053640
EMBL	AF053641	http://www.ebi.ac.uk/ena/data/view/AF053641
EMBL	AF053642	http://www.ebi.ac.uk/ena/data/view/AF053642
EMBL	AF053644	http://www.ebi.ac.uk/ena/data/view/AF053644
EMBL	AF053645	http://www.ebi.ac.uk/ena/data/view/AF053645
EMBL	AF053646	http://www.ebi.ac.uk/ena/data/view/AF053646
EMBL	AF053647	http://www.ebi.ac.uk/ena/data/view/AF053647
EMBL	AF053648	http://www.ebi.ac.uk/ena/data/view/AF053648
EMBL	AF053649	http://www.ebi.ac.uk/ena/data/view/AF053649
EMBL	AF053650	http://www.ebi.ac.uk/ena/data/view/AF053650
EMBL	AF053651	http://www.ebi.ac.uk/ena/data/view/AF053651
EMBL	AK312306	http://www.ebi.ac.uk/ena/data/view/AK312306
EMBL	AL121903	http://www.ebi.ac.uk/ena/data/view/AL121903
EMBL	AL121903	http://www.ebi.ac.uk/ena/data/view/AL121903
EMBL	AL133174	http://www.ebi.ac.uk/ena/data/view/AL133174
EMBL	AL133174	http://www.ebi.ac.uk/ena/data/view/AL133174
EMBL	BC108309	http://www.ebi.ac.uk/ena/data/view/BC108309
EMBL	BC109313	http://www.ebi.ac.uk/ena/data/view/BC109313
EMBL	BC109314	http://www.ebi.ac.uk/ena/data/view/BC109314
EMBL	CH471077	http://www.ebi.ac.uk/ena/data/view/CH471077
EMBL	CH471077	http://www.ebi.ac.uk/ena/data/view/CH471077
EMBL	EF426455	http://www.ebi.ac.uk/ena/data/view/EF426455
EMBL	U33286	http://www.ebi.ac.uk/ena/data/view/U33286
Ensembl	ENST00000262982	http://www.ensembl.org/id/ENST00000262982
Ensembl	ENST00000396192	http://www.ensembl.org/id/ENST00000396192
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005049	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005049
GO_process	GO:0006606	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006606
GO_process	GO:0006915	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006915
GO_process	GO:0008283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008283
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
GOslim_process	GO:0008219	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219
GOslim_process	GO:0008283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008283
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
GeneCards	CSE1L	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CSE1L
GeneID	1434	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1434
GeneTree	ENSGT00550000074884	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074884
HGNC	HGNC:2431	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2431
HOVERGEN	HBG080050	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG080050&db=HOVERGEN
HPA	CAB002140	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB002140
HPA	HPA038059	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA038059
HPA	HPA038060	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA038060
InParanoid	P55060	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P55060
IntAct	P55060	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P55060*
InterPro	IPR001494	http://www.ebi.ac.uk/interpro/entry/IPR001494
InterPro	IPR005043	http://www.ebi.ac.uk/interpro/entry/IPR005043
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR013713	http://www.ebi.ac.uk/interpro/entry/IPR013713
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
Jabion	1434	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1434
KEGG_Gene	hsa:1434	http://www.genome.jp/dbget-bin/www_bget?hsa:1434
MIM	601342	http://www.ncbi.nlm.nih.gov/omim/601342
MINT	MINT-5001090	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5001090
OMA	SGQVEKK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SGQVEKK
OrthoDB	EOG091G01TH	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01TH
PROSITE	PS50166	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50166
PSORT	swissprot:XPO2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:XPO2_HUMAN
PSORT-B	swissprot:XPO2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:XPO2_HUMAN
PSORT2	swissprot:XPO2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:XPO2_HUMAN
Pfam	PF03378	http://pfam.xfam.org/family/PF03378
Pfam	PF03810	http://pfam.xfam.org/family/PF03810
Pfam	PF08506	http://pfam.xfam.org/family/PF08506
PharmGKB	PA26933	http://www.pharmgkb.org/do/serve?objId=PA26933&objCls=Gene
Phobius	swissprot:XPO2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:XPO2_HUMAN
PhylomeDB	P55060	http://phylomedb.org/?seqid=P55060
ProteinModelPortal	P55060	http://www.proteinmodelportal.org/query/uniprot/P55060
PubMed	10331944	http://www.ncbi.nlm.nih.gov/pubmed/10331944
PubMed	11703094	http://www.ncbi.nlm.nih.gov/pubmed/11703094
PubMed	11780052	http://www.ncbi.nlm.nih.gov/pubmed/11780052
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22223895	http://www.ncbi.nlm.nih.gov/pubmed/22223895
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	7479798	http://www.ncbi.nlm.nih.gov/pubmed/7479798
PubMed	9323134	http://www.ncbi.nlm.nih.gov/pubmed/9323134
PubMed	9786944	http://www.ncbi.nlm.nih.gov/pubmed/9786944
RefSeq	NP_001243064	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243064
RefSeq	NP_001307	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001307
RefSeq	XP_011526901	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011526901
SMART	SM00913	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00913
SMR	P55060	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P55060
STRING	9606.ENSP00000262982	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000262982&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
TCDB	1.I.1.1	http://www.tcdb.org/search/result.php?tc=1.I.1.1
UCSC	uc002xty	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002xty&org=rat
UniGene	Hs.90073	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.90073
UniProtKB	XPO2_HUMAN	http://www.uniprot.org/uniprot/XPO2_HUMAN
UniProtKB-AC	P55060	http://www.uniprot.org/uniprot/P55060
charge	swissprot:XPO2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:XPO2_HUMAN
eggNOG	COG5657	http://eggnogapi.embl.de/nog_data/html/tree/COG5657
eggNOG	KOG1992	http://eggnogapi.embl.de/nog_data/html/tree/KOG1992
epestfind	swissprot:XPO2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:XPO2_HUMAN
garnier	swissprot:XPO2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:XPO2_HUMAN
helixturnhelix	swissprot:XPO2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:XPO2_HUMAN
hmoment	swissprot:XPO2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:XPO2_HUMAN
iep	swissprot:XPO2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:XPO2_HUMAN
inforesidue	swissprot:XPO2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:XPO2_HUMAN
neXtProt	NX_P55060	http://www.nextprot.org/db/entry/NX_P55060
octanol	swissprot:XPO2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:XPO2_HUMAN
pepcoil	swissprot:XPO2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:XPO2_HUMAN
pepdigest	swissprot:XPO2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:XPO2_HUMAN
pepinfo	swissprot:XPO2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:XPO2_HUMAN
pepnet	swissprot:XPO2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:XPO2_HUMAN
pepstats	swissprot:XPO2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:XPO2_HUMAN
pepwheel	swissprot:XPO2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:XPO2_HUMAN
pepwindow	swissprot:XPO2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:XPO2_HUMAN
sigcleave	swissprot:XPO2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:XPO2_HUMAN
## Database	ID	URL or Descriptions
# DISEASE	ACHE_HUMAN	Myasthenic syndrome, congenital, 4A, slow-channel (CMS4A) [MIM 605809]  A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. CMS4A is a slow-channel myasthenic syndrome. It is caused by kinetic abnormalities of the AChR, resulting in prolonged AChR channel opening episodes, prolonged endplate currents, and depolarization block. This is associated with calcium overload, which may contribute to subsequent degeneration of the endplate and postsynaptic membrane. {ECO 0000269|PubMed 12141316, ECO 0000269|PubMed 7531341, ECO 0000269|PubMed 7538206, ECO 0000269|PubMed 8872460}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ACHE_HUMAN	Myasthenic syndrome, congenital, 4B, fast-channel (CMS4B) [MIM 616324]  A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. CMS4B is a fast-channel myasthenic syndrome. It is caused by kinetic abnormalities of the AChR, resulting in brief opening and activity of the channel, with a rapid decay in endplate current, failure to achieve threshold depolarization of the endplate and consequent failure to fire an action potential. {ECO 0000269|PubMed 10962020, ECO 0000269|PubMed 22592360, ECO 0000269|PubMed 8755487}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ACHE_HUMAN	Myasthenic syndrome, congenital, 4C, associated with acetylcholine receptor deficiency (CMS4C) [MIM 608931]  A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. CMS4C is an autosomal recessive disorder of postsynaptic neuromuscular transmission, due to deficiency of AChR at the endplate that results in low amplitude of the miniature endplate potential and current. {ECO 0000269|PubMed 9158150}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ACHE_HUMAN	Note=The muscle AChR is the major target antigen in the autoimmune disease myasthenia gravis. Myasthenia gravis is characterized by sporadic muscular fatigability and weakness, occurring chiefly in muscles innervated by cranial nerves, and characteristically improved by cholinesterase-inhibiting drugs. 
# DrugBank	DB00674	Galantamine
# Ensembl	ENST00000293780	ENSP00000293780; ENSG00000108556
# FUNCTION	ACHE_HUMAN	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0005892	acetylcholine-gated channel complex; TAS:ProtInc.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0004889	acetylcholine-activated cation-selective channel activity; TAS:ProtInc.
# GO_function	GO:0008324	cation transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0015276	ligand-gated ion channel activity; TAS:Reactome.
# GO_function	GO:0015464	acetylcholine receptor activity; TAS:ProtInc.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006936	muscle contraction; TAS:ProtInc.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0007271	synaptic transmission, cholinergic; TAS:ProtInc.
# GO_process	GO:0007274	neuromuscular synaptic transmission; IBA:GO_Central.
# GO_process	GO:0035094	response to nicotine; IBA:GO_Central.
# GO_process	GO:0042391	regulation of membrane potential; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.20.120.370	-; 2.
# Gene3D	2.70.170.10	-; 1.
# Genevisible	Q04844	HS
# HGNC	HGNC:1966	CHRNE
# InterPro	IPR002394	Nicotinic_acetylcholine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# InterPro	IPR027361	Acetylcholine_rcpt_TM
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00770	[Nervous system disease] Congenital myasthenic syndrome
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# MIM	100725	gene
# MIM	254200	phenotype
# MIM	605809	phenotype
# MIM	608931	phenotype
# MIM	616324	phenotype
# Organism	ACHE_HUMAN	Homo sapiens (Human)
# Orphanet	98913	Postsynaptic congenital myasthenic syndromes
# PANTHER	PTHR18945	PTHR18945; 2
# PDB	2DF9	Model; -; A=240-332
# PIR	S34775	S34775
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00254	NICOTINICR
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-629587	Highly sodium permeable acetylcholine nicotinic receptors
# RecName	ACHE_HUMAN	Acetylcholine receptor subunit epsilon
# RefSeq	NP_000071	NM_000080.3
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Epsilon/CHRNE sub-subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	ACHE_HUMAN	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	ACHE_HUMAN	Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TCDB	1.A.9.1	the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family
# UCSC	uc002fzk	human
# eggNOG	ENOG410XQGR	LUCA
# eggNOG	KOG3645	Eukaryota
BLAST	swissprot:ACHE_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ACHE_HUMAN
BioCyc	ZFISH:ENSG00000108556-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000108556-MONOMER
COXPRESdb	1145	http://coxpresdb.jp/data/gene/1145.shtml
CleanEx	HS_CHRNE	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CHRNE
DOI	10.1016/S0896-6273(00)80289-5	http://dx.doi.org/10.1016/S0896-6273(00)80289-5
DOI	10.1073/pnas.92.3.758	http://dx.doi.org/10.1073/pnas.92.3.758
DOI	10.1085/jgp.116.3.449	http://dx.doi.org/10.1085/jgp.116.3.449
DOI	10.1093/hmg/5.9.1217	http://dx.doi.org/10.1093/hmg/5.9.1217
DOI	10.1093/hmg/6.5.753	http://dx.doi.org/10.1093/hmg/6.5.753
DOI	10.1111/j.1432-1033.1993.tb18027.x	http://dx.doi.org/10.1111/j.1432-1033.1993.tb18027.x
DOI	10.1212/WNL.0b013e31825b5bda	http://dx.doi.org/10.1212/WNL.0b013e31825b5bda
DOI	10.1212/WNL.45.5.982	http://dx.doi.org/10.1212/WNL.45.5.982
DOI	10.1212/WNL.59.2.162	http://dx.doi.org/10.1212/WNL.59.2.162
DrugBank	DB00674	http://www.drugbank.ca/drugs/DB00674
EMBL	AF105999	http://www.ebi.ac.uk/ena/data/view/AF105999
EMBL	CH471108	http://www.ebi.ac.uk/ena/data/view/CH471108
EMBL	CH471108	http://www.ebi.ac.uk/ena/data/view/CH471108
EMBL	X66403	http://www.ebi.ac.uk/ena/data/view/X66403
Ensembl	ENST00000293780	http://www.ensembl.org/id/ENST00000293780
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005892	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005892
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0004889	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004889
GO_function	GO:0008324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008324
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_function	GO:0015464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015464
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006936	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006936
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007271
GO_process	GO:0007274	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007274
GO_process	GO:0035094	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035094
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.20.120.370	http://www.cathdb.info/version/latest/superfamily/1.20.120.370
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	CHRNE	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CHRNE
GeneID	1145	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1145
GeneTree	ENSGT00760000118930	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118930
H-InvDB	HIX0027273	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0027273
HGNC	HGNC:1966	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1966
HOGENOM	HOG000006757	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006757&db=HOGENOM6
HOVERGEN	HBG003756	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003756&db=HOVERGEN
InParanoid	Q04844	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q04844
InterPro	IPR002394	http://www.ebi.ac.uk/interpro/entry/IPR002394
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
InterPro	IPR027361	http://www.ebi.ac.uk/interpro/entry/IPR027361
Jabion	1145	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1145
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00770	http://www.genome.jp/dbget-bin/www_bget?H00770
KEGG_Gene	hsa:1145	http://www.genome.jp/dbget-bin/www_bget?hsa:1145
KEGG_Orthology	KO:K04817	http://www.genome.jp/dbget-bin/www_bget?KO:K04817
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
MIM	100725	http://www.ncbi.nlm.nih.gov/omim/100725
MIM	254200	http://www.ncbi.nlm.nih.gov/omim/254200
MIM	605809	http://www.ncbi.nlm.nih.gov/omim/605809
MIM	608931	http://www.ncbi.nlm.nih.gov/omim/608931
MIM	616324	http://www.ncbi.nlm.nih.gov/omim/616324
OMA	RHRHGTW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RHRHGTW
Orphanet	98913	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98913
OrthoDB	EOG091G0R20	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0R20
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PDB	2DF9	http://www.ebi.ac.uk/pdbe-srv/view/entry/2DF9
PDBsum	2DF9	http://www.ebi.ac.uk/pdbsum/2DF9
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00254	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00254
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:ACHE_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ACHE_HUMAN
PSORT-B	swissprot:ACHE_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ACHE_HUMAN
PSORT2	swissprot:ACHE_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ACHE_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA26498	http://www.pharmgkb.org/do/serve?objId=PA26498&objCls=Gene
Phobius	swissprot:ACHE_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ACHE_HUMAN
PhylomeDB	Q04844	http://phylomedb.org/?seqid=Q04844
ProteinModelPortal	Q04844	http://www.proteinmodelportal.org/query/uniprot/Q04844
PubMed	10962020	http://www.ncbi.nlm.nih.gov/pubmed/10962020
PubMed	12141316	http://www.ncbi.nlm.nih.gov/pubmed/12141316
PubMed	22592360	http://www.ncbi.nlm.nih.gov/pubmed/22592360
PubMed	7531341	http://www.ncbi.nlm.nih.gov/pubmed/7531341
PubMed	7538206	http://www.ncbi.nlm.nih.gov/pubmed/7538206
PubMed	7688301	http://www.ncbi.nlm.nih.gov/pubmed/7688301
PubMed	8755487	http://www.ncbi.nlm.nih.gov/pubmed/8755487
PubMed	8872460	http://www.ncbi.nlm.nih.gov/pubmed/8872460
PubMed	9158150	http://www.ncbi.nlm.nih.gov/pubmed/9158150
Reactome	R-HSA-629587	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-629587
RefSeq	NP_000071	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000071
STRING	9606.ENSP00000293780	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000293780&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TCDB	1.A.9.1	http://www.tcdb.org/search/result.php?tc=1.A.9.1
UCSC	uc002fzk	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002fzk&org=rat
UniGene	Hs.654535	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.654535
UniProtKB	ACHE_HUMAN	http://www.uniprot.org/uniprot/ACHE_HUMAN
UniProtKB-AC	Q04844	http://www.uniprot.org/uniprot/Q04844
charge	swissprot:ACHE_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ACHE_HUMAN
eggNOG	ENOG410XQGR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQGR
eggNOG	KOG3645	http://eggnogapi.embl.de/nog_data/html/tree/KOG3645
epestfind	swissprot:ACHE_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ACHE_HUMAN
garnier	swissprot:ACHE_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ACHE_HUMAN
helixturnhelix	swissprot:ACHE_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACHE_HUMAN
hmoment	swissprot:ACHE_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ACHE_HUMAN
iep	swissprot:ACHE_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ACHE_HUMAN
inforesidue	swissprot:ACHE_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ACHE_HUMAN
neXtProt	NX_Q04844	http://www.nextprot.org/db/entry/NX_Q04844
octanol	swissprot:ACHE_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ACHE_HUMAN
pepcoil	swissprot:ACHE_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ACHE_HUMAN
pepdigest	swissprot:ACHE_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ACHE_HUMAN
pepinfo	swissprot:ACHE_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ACHE_HUMAN
pepnet	swissprot:ACHE_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ACHE_HUMAN
pepstats	swissprot:ACHE_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ACHE_HUMAN
pepwheel	swissprot:ACHE_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ACHE_HUMAN
pepwindow	swissprot:ACHE_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ACHE_HUMAN
sigcleave	swissprot:ACHE_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ACHE_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	IRPL1_HUMAN	Event=Alternative splicing; Named isoforms=1; Comment=A number of isoforms are produced.; Name=1; IsoId=Q9NZN1-1; Sequence=Displayed; 
# AltName	IRPL1_HUMAN	Oligophrenin-4
# AltName	IRPL1_HUMAN	Three immunoglobulin domain-containing IL-1 receptor-related 2
# AltName	IRPL1_HUMAN	X-linked interleukin-1 receptor accessory protein-like 1
# BioGrid	116313	2
# CCDS	CCDS14218	-. [Q9NZN1-1]
# ChiTaRS	IL1RAPL1	human
# DISEASE	IRPL1_HUMAN	Mental retardation, X-linked 21 (MRX21) [MIM 300143]  A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non- syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. {ECO 0000269|PubMed 10757639, ECO 0000269|PubMed 16470793}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000378993	ENSP00000368278; ENSG00000169306. [Q9NZN1-1]
# ExpressionAtlas	Q9NZN1	baseline and differential
# FUNCTION	IRPL1_HUMAN	May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons. {ECO 0000269|PubMed 12783849, ECO 0000269|PubMed 15123616}. 
# GO_component	GO:0005737	cytoplasm; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0009986	cell surface; ISS:BHF-UCL.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0030424	axon; IEA:UniProtKB-SubCell.
# GO_component	GO:0030425	dendrite; ISS:BHF-UCL.
# GO_component	GO:0045211	postsynaptic membrane; NAS:BHF-UCL.
# GO_function	GO:0005102	receptor binding; ISS:BHF-UCL.
# GO_function	GO:0005245	voltage-gated calcium channel activity; ISS:UniProtKB.
# GO_process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; ISS:BHF-UCL.
# GO_process	GO:0007165	signal transduction; IEA:InterPro.
# GO_process	GO:0010975	regulation of neuron projection development; ISS:UniProtKB.
# GO_process	GO:0030182	neuron differentiation; ISS:BHF-UCL.
# GO_process	GO:0045920	negative regulation of exocytosis; IDA:UniProtKB.
# GO_process	GO:0050775	positive regulation of dendrite morphogenesis; ISS:BHF-UCL.
# GO_process	GO:0097105	presynaptic membrane assembly; ISS:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0007155	cell adhesion
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0022607	cellular component assembly
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0061024	membrane organization
# Gene3D	2.60.40.10	-; 3.
# Gene3D	3.40.50.10140	-; 1.
# Genevisible	Q9NZN1	HS
# HGNC	HGNC:5996	IL1RAPL1
# InterPro	IPR000157	TIR_dom
# InterPro	IPR003598	Ig_sub2
# InterPro	IPR003599	Ig_sub
# InterPro	IPR007110	Ig-like_dom
# InterPro	IPR013151	Immunoglobulin
# InterPro	IPR013783	Ig-like_fold
# InterPro	IPR015621	IL-1_rcpt_fam
# KEGG_Brite	ko04050	Cytokine receptors
# KEGG_Disease	H00480	[Congenital disorder; Mental retardation] Non-syndromic X-linked mental retardation
# MIM	300143	phenotype
# MIM	300206	gene
# Organism	IRPL1_HUMAN	Homo sapiens (Human)
# Orphanet	777	X-linked non-syndromic intellectual disability
# PANTHER	PTHR11890	PTHR11890
# PDB	1T3G	X-ray; 2.30 A; A/B=403-561
# PDB	4M92	X-ray; 1.60 A; B=207-222
# PROSITE	PS50104	TIR
# PROSITE	PS50835	IG_LIKE; 3
# Pfam	PF00047	ig
# Pfam	PF01582	TIR
# Proteomes	UP000005640	Chromosome X
# RecName	IRPL1_HUMAN	Interleukin-1 receptor accessory protein-like 1
# RefSeq	NP_055086	NM_014271.3. [Q9NZN1-1]
# RefSeq	XP_016884729	XM_017029240.1. [Q9NZN1-1]
# SIMILARITY	Belongs to the interleukin-1 receptor family. {ECO	0000305}. 
# SIMILARITY	Contains 1 TIR domain. {ECO:0000255|PROSITE- ProRule	PRU00204}.
# SIMILARITY	Contains 3 Ig-like C2-type (immunoglobulin-like) domains. {ECO	0000305}. 
# SMART	SM00255	TIR
# SMART	SM00408	IGc2; 2
# SMART	SM00409	IG; 3
# SUBCELLULAR LOCATION	IRPL1_HUMAN	Cell membrane {ECO 0000269|PubMed 12783849}; Single-pass type I membrane protein {ECO 0000269|PubMed 12783849}. Cytoplasm {ECO 0000269|PubMed 12783849}. Cell projection, axon {ECO 0000250}. Cell projection, dendrite {ECO 0000250}. Note=May localize to the cell body and growth cones of dendrite-like processes. {ECO 0000250}. 
# SUBUNIT	Homodimer. Interacts (calcium-independent) with NCS1. Interacts (via extracellular region) with PTPRD; this interaction is required for IL1RAPL1-mediated synapse formation. {ECO:0000269|PubMed	12783849}. 
# SUPFAM	SSF48726	SSF48726; 3
# SUPFAM	SSF52200	SSF52200
# TISSUE SPECIFICITY	IRPL1_HUMAN	Detected at low levels in heart, skeletal muscle, ovary, skin, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Detected at very low levels in tonsil, prostate, testis, small intestine, placenta, colon and fetal liver. {ECO 0000269|PubMed 10471494, ECO 0000269|PubMed 10882729}. 
# eggNOG	ENOG410IF3G	Eukaryota
# eggNOG	ENOG4110Z8K	LUCA
BLAST	swissprot:IRPL1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:IRPL1_HUMAN
BioCyc	ZFISH:ENSG00000169306-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000169306-MONOMER
COXPRESdb	11141	http://coxpresdb.jp/data/gene/11141.shtml
CleanEx	HS_IL1RAPL1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_IL1RAPL1
DOI	10.1002/ajmg.a.31107	http://dx.doi.org/10.1002/ajmg.a.31107
DOI	10.1038/12623	http://dx.doi.org/10.1038/12623
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1038/sj.ejhg.5200415	http://dx.doi.org/10.1038/sj.ejhg.5200415
DOI	10.1074/jbc.M004077200	http://dx.doi.org/10.1074/jbc.M004077200
DOI	10.1074/jbc.M403434200	http://dx.doi.org/10.1074/jbc.M403434200
DOI	10.1093/hmg/ddg147	http://dx.doi.org/10.1093/hmg/ddg147
DOI	10.1093/hmg/ddn300	http://dx.doi.org/10.1093/hmg/ddn300
DOI	10.1093/molbev/msg134	http://dx.doi.org/10.1093/molbev/msg134
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB102650	http://www.ebi.ac.uk/ena/data/view/AB102650
EMBL	AC005748	http://www.ebi.ac.uk/ena/data/view/AC005748
EMBL	AC005748	http://www.ebi.ac.uk/ena/data/view/AC005748
EMBL	AC121343	http://www.ebi.ac.uk/ena/data/view/AC121343
EMBL	AC121343	http://www.ebi.ac.uk/ena/data/view/AC121343
EMBL	AC129852	http://www.ebi.ac.uk/ena/data/view/AC129852
EMBL	AC129852	http://www.ebi.ac.uk/ena/data/view/AC129852
EMBL	AF181284	http://www.ebi.ac.uk/ena/data/view/AF181284
EMBL	AF284435	http://www.ebi.ac.uk/ena/data/view/AF284435
EMBL	AJ243874	http://www.ebi.ac.uk/ena/data/view/AJ243874
EMBL	AL031466	http://www.ebi.ac.uk/ena/data/view/AL031466
EMBL	AL031466	http://www.ebi.ac.uk/ena/data/view/AL031466
EMBL	AL031575	http://www.ebi.ac.uk/ena/data/view/AL031575
EMBL	AL031575	http://www.ebi.ac.uk/ena/data/view/AL031575
EMBL	BC126345	http://www.ebi.ac.uk/ena/data/view/BC126345
EMBL	BC126347	http://www.ebi.ac.uk/ena/data/view/BC126347
EMBL	CH471074	http://www.ebi.ac.uk/ena/data/view/CH471074
Ensembl	ENST00000378993	http://www.ensembl.org/id/ENST00000378993
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030424	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030424
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0005102	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005102
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_process	GO:0007157	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007157
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0010975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010975
GO_process	GO:0030182	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030182
GO_process	GO:0045920	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045920
GO_process	GO:0050775	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050775
GO_process	GO:0097105	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097105
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0007155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0022607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
Gene3D	2.60.40.10	http://www.cathdb.info/version/latest/superfamily/2.60.40.10
Gene3D	3.40.50.10140	http://www.cathdb.info/version/latest/superfamily/3.40.50.10140
GeneCards	IL1RAPL1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=IL1RAPL1
GeneID	11141	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11141
GeneTree	ENSGT00760000119071	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119071
HGNC	HGNC:5996	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:5996
HOGENOM	HOG000092977	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000092977&db=HOGENOM6
HOVERGEN	HBG052148	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052148&db=HOVERGEN
HPA	HPA000564	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA000564
InParanoid	Q9NZN1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NZN1
IntAct	Q9NZN1	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NZN1*
InterPro	IPR000157	http://www.ebi.ac.uk/interpro/entry/IPR000157
InterPro	IPR003598	http://www.ebi.ac.uk/interpro/entry/IPR003598
InterPro	IPR003599	http://www.ebi.ac.uk/interpro/entry/IPR003599
InterPro	IPR007110	http://www.ebi.ac.uk/interpro/entry/IPR007110
InterPro	IPR013151	http://www.ebi.ac.uk/interpro/entry/IPR013151
InterPro	IPR013783	http://www.ebi.ac.uk/interpro/entry/IPR013783
InterPro	IPR015621	http://www.ebi.ac.uk/interpro/entry/IPR015621
Jabion	11141	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=11141
KEGG_Brite	ko04050	http://www.genome.jp/dbget-bin/www_bget?ko04050
KEGG_Disease	H00480	http://www.genome.jp/dbget-bin/www_bget?H00480
KEGG_Gene	hsa:11141	http://www.genome.jp/dbget-bin/www_bget?hsa:11141
KEGG_Orthology	KO:K05170	http://www.genome.jp/dbget-bin/www_bget?KO:K05170
MIM	300143	http://www.ncbi.nlm.nih.gov/omim/300143
MIM	300206	http://www.ncbi.nlm.nih.gov/omim/300206
OMA	KLLHPLE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KLLHPLE
Orphanet	777	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=777
OrthoDB	EOG091G0GXW	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0GXW
PANTHER	PTHR11890	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11890
PDB	1T3G	http://www.ebi.ac.uk/pdbe-srv/view/entry/1T3G
PDB	4M92	http://www.ebi.ac.uk/pdbe-srv/view/entry/4M92
PDBsum	1T3G	http://www.ebi.ac.uk/pdbsum/1T3G
PDBsum	4M92	http://www.ebi.ac.uk/pdbsum/4M92
PROSITE	PS50104	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50104
PROSITE	PS50835	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50835
PSORT	swissprot:IRPL1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:IRPL1_HUMAN
PSORT-B	swissprot:IRPL1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:IRPL1_HUMAN
PSORT2	swissprot:IRPL1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:IRPL1_HUMAN
Pfam	PF00047	http://pfam.xfam.org/family/PF00047
Pfam	PF01582	http://pfam.xfam.org/family/PF01582
PharmGKB	PA29812	http://www.pharmgkb.org/do/serve?objId=PA29812&objCls=Gene
Phobius	swissprot:IRPL1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:IRPL1_HUMAN
PhylomeDB	Q9NZN1	http://phylomedb.org/?seqid=Q9NZN1
ProteinModelPortal	Q9NZN1	http://www.proteinmodelportal.org/query/uniprot/Q9NZN1
PubMed	10471494	http://www.ncbi.nlm.nih.gov/pubmed/10471494
PubMed	10757639	http://www.ncbi.nlm.nih.gov/pubmed/10757639
PubMed	10882729	http://www.ncbi.nlm.nih.gov/pubmed/10882729
PubMed	12777533	http://www.ncbi.nlm.nih.gov/pubmed/12777533
PubMed	12783849	http://www.ncbi.nlm.nih.gov/pubmed/12783849
PubMed	15123616	http://www.ncbi.nlm.nih.gov/pubmed/15123616
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	16470793	http://www.ncbi.nlm.nih.gov/pubmed/16470793
PubMed	18801879	http://www.ncbi.nlm.nih.gov/pubmed/18801879
RefSeq	NP_055086	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055086
RefSeq	XP_016884729	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016884729
SMART	SM00255	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00255
SMART	SM00408	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00408
SMART	SM00409	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00409
SMR	Q9NZN1	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9NZN1
STRING	9606.ENSP00000305200	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000305200&targetmode=cogs
SUPFAM	SSF48726	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48726
SUPFAM	SSF52200	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52200
UniGene	Hs.658912	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.658912
UniProtKB	IRPL1_HUMAN	http://www.uniprot.org/uniprot/IRPL1_HUMAN
UniProtKB-AC	Q9NZN1	http://www.uniprot.org/uniprot/Q9NZN1
charge	swissprot:IRPL1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:IRPL1_HUMAN
eggNOG	ENOG410IF3G	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IF3G
eggNOG	ENOG4110Z8K	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110Z8K
epestfind	swissprot:IRPL1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:IRPL1_HUMAN
garnier	swissprot:IRPL1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:IRPL1_HUMAN
helixturnhelix	swissprot:IRPL1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:IRPL1_HUMAN
hmoment	swissprot:IRPL1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:IRPL1_HUMAN
iep	swissprot:IRPL1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:IRPL1_HUMAN
inforesidue	swissprot:IRPL1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:IRPL1_HUMAN
neXtProt	NX_Q9NZN1	http://www.nextprot.org/db/entry/NX_Q9NZN1
octanol	swissprot:IRPL1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:IRPL1_HUMAN
pepcoil	swissprot:IRPL1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:IRPL1_HUMAN
pepdigest	swissprot:IRPL1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:IRPL1_HUMAN
pepinfo	swissprot:IRPL1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:IRPL1_HUMAN
pepnet	swissprot:IRPL1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:IRPL1_HUMAN
pepstats	swissprot:IRPL1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:IRPL1_HUMAN
pepwheel	swissprot:IRPL1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:IRPL1_HUMAN
pepwindow	swissprot:IRPL1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:IRPL1_HUMAN
sigcleave	swissprot:IRPL1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:IRPL1_HUMAN
## Database	ID	URL or Descriptions
# AltName	TMC1_HUMAN	Transmembrane cochlear-expressed protein 1
# BioGrid	125588	2
# ChiTaRS	TMC1	human
# DISEASE	TMC1_HUMAN	Deafness, autosomal dominant, 36 (DFNA36) [MIM 606705]  A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA36 is a bilateral hearing loss, and begins at 5-10 years of age. It progresses to profound deafness within 10-15 years. {ECO 0000269|PubMed 11850618}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	TMC1_HUMAN	Deafness, autosomal recessive, 7 (DFNB7) [MIM 600974]  A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO 0000269|PubMed 11850618}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000297784	ENSP00000297784; ENSG00000165091
# Ensembl	ENST00000340019	ENSP00000341433; ENSG00000165091
# FUNCTION	TMC1_HUMAN	Probable ion channel required for the normal function of cochlear hair cells. {ECO 0000250}. 
# GO_component	GO:0009897	external side of plasma membrane; IEA:Ensembl.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0032426	stereocilium tip; IEA:Ensembl.
# GO_function	GO:0005245	voltage-gated calcium channel activity; IEA:Ensembl.
# GO_process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound; IEA:Ensembl.
# GO_process	GO:0060005	vestibular reflex; IEA:Ensembl.
# GO_process	GO:0060117	auditory receptor cell development; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# Genevisible	Q8TDI8	HS
# HGNC	HGNC:16513	TMC1
# InterPro	IPR012496	TMC
# KEGG_Disease	H00604	[Nervous system disease; Nervous system disease] Deafness, autosomal dominant
# KEGG_Disease	H00605	[Nervous system disease; Nervous system disease] Deafness, autosomal recessive
# MIM	600974	phenotype
# MIM	606705	phenotype
# MIM	606706	gene
# Organism	TMC1_HUMAN	Homo sapiens (Human)
# Orphanet	90635	Autosomal dominant non-syndromic sensorineural deafness type DFNA
# Orphanet	90636	Autosomal recessive non-syndromic sensorineural deafness type DFNB
# Pfam	PF07810	TMC
# Proteomes	UP000005640	Chromosome 9
# RecName	TMC1_HUMAN	Transmembrane channel-like protein 1
# RefSeq	NP_619636	NM_138691.2
# SEQUENCE CAUTION	Sequence=BAC05351.1; Type=Erroneous termination; Positions=744; Note=Translated as Arg.; Evidence={ECO:0000305}; Sequence=BAC05351.1; Type=Frameshift; Positions=588; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the TMC family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	TMC1_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TISSUE SPECIFICITY	TMC1_HUMAN	Detected in fetal cochlea, and at low levels in placenta and testis. 
# UCSC	uc004aiz	human
# eggNOG	ENOG410IF2J	Eukaryota
# eggNOG	ENOG410XTGF	LUCA
BLAST	swissprot:TMC1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TMC1_HUMAN
BioCyc	ZFISH:ENSG00000165091-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000165091-MONOMER
COXPRESdb	117531	http://coxpresdb.jp/data/gene/117531.shtml
CleanEx	HS_TMC1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TMC1
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/ng842	http://dx.doi.org/10.1038/ng842
EMBL	AF417578	http://www.ebi.ac.uk/ena/data/view/AF417578
EMBL	AK098607	http://www.ebi.ac.uk/ena/data/view/AK098607
EMBL	AL162416	http://www.ebi.ac.uk/ena/data/view/AL162416
EMBL	AL162416	http://www.ebi.ac.uk/ena/data/view/AL162416
EMBL	AL162416	http://www.ebi.ac.uk/ena/data/view/AL162416
EMBL	AL590662	http://www.ebi.ac.uk/ena/data/view/AL590662
EMBL	AL590662	http://www.ebi.ac.uk/ena/data/view/AL590662
EMBL	AL590662	http://www.ebi.ac.uk/ena/data/view/AL590662
EMBL	AL591662	http://www.ebi.ac.uk/ena/data/view/AL591662
EMBL	AL591662	http://www.ebi.ac.uk/ena/data/view/AL591662
EMBL	AL591662	http://www.ebi.ac.uk/ena/data/view/AL591662
EMBL	CH471089	http://www.ebi.ac.uk/ena/data/view/CH471089
Ensembl	ENST00000297784	http://www.ensembl.org/id/ENST00000297784
Ensembl	ENST00000340019	http://www.ensembl.org/id/ENST00000340019
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0009897	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009897
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0032426	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032426
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_process	GO:0050910	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050910
GO_process	GO:0060005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060005
GO_process	GO:0060117	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060117
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	TMC1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TMC1
GeneID	117531	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=117531
GeneTree	ENSGT00760000119171	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119171
H-InvDB	HIX0008098	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0008098
HGNC	HGNC:16513	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16513
HOGENOM	HOG000231742	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231742&db=HOGENOM6
HOVERGEN	HBG036209	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG036209&db=HOVERGEN
HPA	HPA044166	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA044166
HPA	HPA046773	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA046773
InParanoid	Q8TDI8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8TDI8
IntAct	Q8TDI8	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8TDI8*
InterPro	IPR012496	http://www.ebi.ac.uk/interpro/entry/IPR012496
Jabion	117531	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=117531
KEGG_Disease	H00604	http://www.genome.jp/dbget-bin/www_bget?H00604
KEGG_Disease	H00605	http://www.genome.jp/dbget-bin/www_bget?H00605
KEGG_Gene	hsa:117531	http://www.genome.jp/dbget-bin/www_bget?hsa:117531
MIM	600974	http://www.ncbi.nlm.nih.gov/omim/600974
MIM	606705	http://www.ncbi.nlm.nih.gov/omim/606705
MIM	606706	http://www.ncbi.nlm.nih.gov/omim/606706
OMA	MIATVKC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MIATVKC
Orphanet	90635	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=90635
Orphanet	90636	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=90636
OrthoDB	EOG091G00X0	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00X0
PSORT	swissprot:TMC1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TMC1_HUMAN
PSORT-B	swissprot:TMC1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TMC1_HUMAN
PSORT2	swissprot:TMC1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TMC1_HUMAN
Pfam	PF07810	http://pfam.xfam.org/family/PF07810
PharmGKB	PA38156	http://www.pharmgkb.org/do/serve?objId=PA38156&objCls=Gene
Phobius	swissprot:TMC1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TMC1_HUMAN
PhylomeDB	Q8TDI8	http://phylomedb.org/?seqid=Q8TDI8
ProteinModelPortal	Q8TDI8	http://www.proteinmodelportal.org/query/uniprot/Q8TDI8
PubMed	11850618	http://www.ncbi.nlm.nih.gov/pubmed/11850618
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
RefSeq	NP_619636	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_619636
STRING	9606.ENSP00000297784	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000297784&targetmode=cogs
UCSC	uc004aiz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004aiz&org=rat
UniGene	Hs.670211	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.670211
UniProtKB	TMC1_HUMAN	http://www.uniprot.org/uniprot/TMC1_HUMAN
UniProtKB-AC	Q8TDI8	http://www.uniprot.org/uniprot/Q8TDI8
charge	swissprot:TMC1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TMC1_HUMAN
eggNOG	ENOG410IF2J	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IF2J
eggNOG	ENOG410XTGF	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XTGF
epestfind	swissprot:TMC1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TMC1_HUMAN
garnier	swissprot:TMC1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TMC1_HUMAN
helixturnhelix	swissprot:TMC1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TMC1_HUMAN
hmoment	swissprot:TMC1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TMC1_HUMAN
iep	swissprot:TMC1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TMC1_HUMAN
inforesidue	swissprot:TMC1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TMC1_HUMAN
neXtProt	NX_Q8TDI8	http://www.nextprot.org/db/entry/NX_Q8TDI8
octanol	swissprot:TMC1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TMC1_HUMAN
pepcoil	swissprot:TMC1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TMC1_HUMAN
pepdigest	swissprot:TMC1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TMC1_HUMAN
pepinfo	swissprot:TMC1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TMC1_HUMAN
pepnet	swissprot:TMC1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TMC1_HUMAN
pepstats	swissprot:TMC1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TMC1_HUMAN
pepwheel	swissprot:TMC1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TMC1_HUMAN
pepwindow	swissprot:TMC1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TMC1_HUMAN
sigcleave	swissprot:TMC1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TMC1_HUMAN
## Database	ID	URL or Descriptions
# CAUTION	Could be the product of a pseudogene. {ECO	0000305}.
# Ensembl	ENST00000505920	ENSP00000421076; ENSG00000249222
# FUNCTION	AT5L2_HUMAN	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity). {ECO 0000250}. 
# GO_component	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); IBA:GO_Central.
# GO_component	GO:0005739	mitochondrion; IDA:HPA.
# GO_function	GO:0015078	hydrogen ion transmembrane transporter activity; IEA:InterPro.
# GO_process	GO:0015986	ATP synthesis coupled proton transport; IBA:GO_Central.
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# HGNC	HGNC:13213	ATP5L2
# InterPro	IPR006808	ATP_synth_F0_gsu_mt
# InterPro	IPR016702	ATP_synth_su_G_mt_met
# Organism	AT5L2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12386	PTHR12386
# PIRSF	PIRSF017835	ATP-synth_g_mitoch_animal
# Pfam	PF04718	ATP-synt_G
# Proteomes	UP000005640	Chromosome 22
# RecName	AT5L2_HUMAN	ATP synthase subunit g 2, mitochondrial
# RefSeq	NP_001159349	NM_001165877.1
# SIMILARITY	Belongs to the ATPase g subunit family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	AT5L2_HUMAN	Mitochondrion membrane {ECO 0000250}. 
# SUBUNIT	F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits	 a, b, c, d, e, f, g, F6 and 8 (or A6L). 
# UCSC	uc003bda	human
# eggNOG	ENOG4111TZ1	LUCA
# eggNOG	KOG4103	Eukaryota
BLAST	swissprot:AT5L2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AT5L2_HUMAN
BioCyc	ZFISH:G66-31097-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31097-MONOMER
COXPRESdb	267020	http://coxpresdb.jp/data/gene/267020.shtml
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF092923	http://www.ebi.ac.uk/ena/data/view/AF092923
EMBL	BC093719	http://www.ebi.ac.uk/ena/data/view/BC093719
EMBL	BC093721	http://www.ebi.ac.uk/ena/data/view/BC093721
Ensembl	ENST00000505920	http://www.ensembl.org/id/ENST00000505920
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000276
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_function	GO:0015078	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015078
GO_process	GO:0015986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015986
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ATP5L2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP5L2
GeneID	267020	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=267020
GeneTree	ENSGT00390000009724	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000009724
HGNC	HGNC:13213	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13213
HOGENOM	HOG000007506	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007506&db=HOGENOM6
HOVERGEN	HBG050614	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050614&db=HOVERGEN
HPA	HPA044629	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA044629
InParanoid	Q7Z4Y8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q7Z4Y8
InterPro	IPR006808	http://www.ebi.ac.uk/interpro/entry/IPR006808
InterPro	IPR016702	http://www.ebi.ac.uk/interpro/entry/IPR016702
Jabion	267020	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=267020
KEGG_Gene	hsa:267020	http://www.genome.jp/dbget-bin/www_bget?hsa:267020
OMA	ATEVSTW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ATEVSTW
OrthoDB	EOG091G16ZZ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G16ZZ
PANTHER	PTHR12386	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12386
PSORT	swissprot:AT5L2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AT5L2_HUMAN
PSORT-B	swissprot:AT5L2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AT5L2_HUMAN
PSORT2	swissprot:AT5L2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AT5L2_HUMAN
Pfam	PF04718	http://pfam.xfam.org/family/PF04718
PharmGKB	PA134948694	http://www.pharmgkb.org/do/serve?objId=PA134948694&objCls=Gene
Phobius	swissprot:AT5L2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AT5L2_HUMAN
PhylomeDB	Q7Z4Y8	http://phylomedb.org/?seqid=Q7Z4Y8
ProteinModelPortal	Q7Z4Y8	http://www.proteinmodelportal.org/query/uniprot/Q7Z4Y8
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
RefSeq	NP_001159349	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001159349
STRING	9606.ENSP00000421076	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000421076&targetmode=cogs
UCSC	uc003bda	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003bda&org=rat
UniGene	Hs.664737	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.664737
UniProtKB	AT5L2_HUMAN	http://www.uniprot.org/uniprot/AT5L2_HUMAN
UniProtKB-AC	Q7Z4Y8	http://www.uniprot.org/uniprot/Q7Z4Y8
charge	swissprot:AT5L2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AT5L2_HUMAN
eggNOG	ENOG4111TZ1	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111TZ1
eggNOG	KOG4103	http://eggnogapi.embl.de/nog_data/html/tree/KOG4103
epestfind	swissprot:AT5L2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AT5L2_HUMAN
garnier	swissprot:AT5L2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AT5L2_HUMAN
helixturnhelix	swissprot:AT5L2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AT5L2_HUMAN
hmoment	swissprot:AT5L2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AT5L2_HUMAN
iep	swissprot:AT5L2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AT5L2_HUMAN
inforesidue	swissprot:AT5L2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AT5L2_HUMAN
neXtProt	NX_Q7Z4Y8	http://www.nextprot.org/db/entry/NX_Q7Z4Y8
octanol	swissprot:AT5L2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AT5L2_HUMAN
pepcoil	swissprot:AT5L2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AT5L2_HUMAN
pepdigest	swissprot:AT5L2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AT5L2_HUMAN
pepinfo	swissprot:AT5L2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AT5L2_HUMAN
pepnet	swissprot:AT5L2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AT5L2_HUMAN
pepstats	swissprot:AT5L2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AT5L2_HUMAN
pepwheel	swissprot:AT5L2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AT5L2_HUMAN
pepwindow	swissprot:AT5L2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AT5L2_HUMAN
sigcleave	swissprot:AT5L2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AT5L2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ACHA_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=2; IsoId=P02708-1; Sequence=Displayed; Name=1; IsoId=P02708-2; Sequence=VSP_000071; 
# BioGrid	107556	4
# CCDS	CCDS2261	-. [P02708-2]
# CCDS	CCDS33331	-. [P02708-1]
# DISEASE	ACHA_HUMAN	Multiple pterygium syndrome, lethal type (LMPS) [MIM 253290]  Multiple pterygia are found infrequently in children with arthrogryposis and in fetuses with fetal akinesia syndrome. In lethal multiple pterygium syndrome there is intrauterine growth retardation, multiple pterygia, and flexion contractures causing severe arthrogryposis and fetal akinesia. Subcutaneous edema can be severe, causing fetal hydrops with cystic hygroma and lung hypoplasia. Oligohydramnios and facial anomalies are frequent. {ECO 0000269|PubMed 18252226}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ACHA_HUMAN	Myasthenic syndrome, congenital, 1A, slow-channel (CMS1A) [MIM 601462]  A common congenital myasthenic syndrome. Congenital myasthenic syndromes are characterized by muscle weakness affecting the axial and limb muscles (with hypotonia in early- onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. CMS1A is a slow-channel myasthenic syndrome. It is caused by kinetic abnormalities of the AChR, resulting in prolonged AChR channel opening episodes, prolonged endplate currents, and depolarization block. This is associated with calcium overload, which may contribute to subsequent degeneration of the endplate and postsynaptic membrane. {ECO 0000269|PubMed 16685696, ECO 0000269|PubMed 7619526, ECO 0000269|PubMed 8872460, ECO 0000269|PubMed 9158151, ECO 0000269|PubMed 9221765}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ACHA_HUMAN	Myasthenic syndrome, congenital, 1B, fast-channel (CMS1B) [MIM 608930]  A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. CMS1B is a fast-channel myasthenic syndrome. It is caused by kinetic abnormalities of the AChR, resulting in brief opening and activity of the channel, with a rapid decay in endplate current, failure to achieve threshold depolarization of the endplate and consequent failure to fire an action potential. {ECO 0000269|PubMed 10195214, ECO 0000269|PubMed 12588888, ECO 0000269|PubMed 15079006}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ACHA_HUMAN	Note=The alpha subunit is the main focus for antibody binding in myasthenia gravis. Myasthenia gravis is characterized by sporadic muscular fatigability and weakness, occurring chiefly in muscles innervated by cranial nerves, and characteristically improved by cholinesterase-inhibiting drugs. 
# DrugBank	DB00674	Galantamine
# Ensembl	ENST00000261007	ENSP00000261007; ENSG00000138435. [P02708-1]
# Ensembl	ENST00000348749	ENSP00000261008; ENSG00000138435. [P02708-2]
# ExpressionAtlas	P02708	baseline and differential
# FUNCTION	ACHA_HUMAN	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. 
# GO_component	GO:0005886	plasma membrane; ISS:BHF-UCL.
# GO_component	GO:0005892	acetylcholine-gated channel complex; ISS:BHF-UCL.
# GO_component	GO:0009986	cell surface; IDA:BHF-UCL.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0031594	neuromuscular junction; ISS:BHF-UCL.
# GO_component	GO:0045211	postsynaptic membrane; NAS:BHF-UCL.
# GO_function	GO:0004889	acetylcholine-activated cation-selective channel activity; IMP:MGI.
# GO_function	GO:0005216	ion channel activity; TAS:ProtInc.
# GO_function	GO:0015276	ligand-gated ion channel activity; TAS:Reactome.
# GO_function	GO:0015464	acetylcholine receptor activity; TAS:ProtInc.
# GO_function	GO:0042166	acetylcholine binding; IEA:Ensembl.
# GO_process	GO:0003009	skeletal muscle contraction; IMP:BHF-UCL.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0007271	synaptic transmission, cholinergic; IBA:GO_Central.
# GO_process	GO:0007274	neuromuscular synaptic transmission; IMP:MGI.
# GO_process	GO:0007528	neuromuscular junction development; IMP:MGI.
# GO_process	GO:0019228	neuronal action potential; IMP:BHF-UCL.
# GO_process	GO:0035094	response to nicotine; IBA:GO_Central.
# GO_process	GO:0042391	regulation of membrane potential; IMP:BHF-UCL.
# GO_process	GO:0046716	muscle cell cellular homeostasis; IMP:BHF-UCL.
# GO_process	GO:0048630	skeletal muscle tissue growth; IMP:BHF-UCL.
# GO_process	GO:0050881	musculoskeletal movement; IMP:BHF-UCL.
# GO_process	GO:0050905	neuromuscular process; IMP:BHF-UCL.
# GO_process	GO:0070050	neuron cellular homeostasis; IMP:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0040007	growth
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0050877	neurological system process
# Gene3D	1.20.120.370	-; 2.
# Gene3D	2.70.170.10	-; 1.
# Genevisible	P02708	HS
# HGNC	HGNC:1955	CHRNA1
# IntAct	P02708	3
# InterPro	IPR002394	Nicotinic_acetylcholine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# InterPro	IPR027361	Acetylcholine_rcpt_TM
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00770	[Nervous system disease] Congenital myasthenic syndrome
# KEGG_Disease	H00986	[Developmental disorder] Multiple pterygium syndrome, Escobar variant (EVMPS)
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# MIM	100690	gene
# MIM	253290	phenotype
# MIM	254200	phenotype
# MIM	601462	phenotype
# MIM	608930	phenotype
# Organism	ACHA_HUMAN	Homo sapiens (Human)
# Orphanet	33108	Lethal multiple pterygium syndrome
# Orphanet	98913	Postsynaptic congenital myasthenic syndromes
# PANTHER	PTHR18945	PTHR18945; 2
# PDB	1Y5P	Model; -; B=230-235
# PDB	1Y5T	Model; -; B=230-235
# PDB	1Y6C	Model; -; B=230-235
# PDB	4ZJS	X-ray; 2.23 A; A/B/C/D/E=21-50, A/B/C/D/E=106-126
# PIR	A03168	ACHUA1
# PIR	S10148	S10148
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00254	NICOTINICR
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD; 2
# Pfam	PF02932	Neur_chan_memb; 2
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-629594	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
# Reactome	R-HSA-629597	Highly calcium permeable nicotinic acetylcholine receptors
# RecName	ACHA_HUMAN	Acetylcholine receptor subunit alpha
# RefSeq	NP_000070	NM_000079.3. [P02708-2]
# RefSeq	NP_001034612	NM_001039523.2. [P02708-1]
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 1/CHRNA1 sub-subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	ACHA_HUMAN	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	ACHA_HUMAN	Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains. 
# SUPFAM	SSF63712	SSF63712; 2
# SUPFAM	SSF90112	SSF90112
# TCDB	1.A.9.1	the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family
# TISSUE SPECIFICITY	ACHA_HUMAN	Isoform 1 is only expressed in skeletal muscle. Isoform 2 is constitutively expressed in skeletal muscle, brain, heart, kidney, liver, lung and thymus. 
# UCSC	uc002ujd	human. [P02708-1]
# eggNOG	ENOG410XQGR	LUCA
# eggNOG	KOG3645	Eukaryota
BLAST	swissprot:ACHA_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ACHA_HUMAN
BioCyc	ZFISH:ENSG00000138435-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000138435-MONOMER
COXPRESdb	1134	http://coxpresdb.jp/data/gene/1134.shtml
CleanEx	HS_CHRNA1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CHRNA1
DOI	10.1002/ana.20861	http://dx.doi.org/10.1002/ana.20861
DOI	10.1016/0014-5793(88)81430-3	http://dx.doi.org/10.1016/0014-5793(88)81430-3
DOI	10.1016/0896-6273(95)90080-2	http://dx.doi.org/10.1016/0896-6273(95)90080-2
DOI	10.1016/j.ajhg.2007.11.006	http://dx.doi.org/10.1016/j.ajhg.2007.11.006
DOI	10.1038/305818a0	http://dx.doi.org/10.1038/305818a0
DOI	10.1038/6326	http://dx.doi.org/10.1038/6326
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/hmg/5.9.1217	http://dx.doi.org/10.1093/hmg/5.9.1217
DOI	10.1093/hmg/6.5.767	http://dx.doi.org/10.1093/hmg/6.5.767
DOI	10.1093/nar/21.2.233	http://dx.doi.org/10.1093/nar/21.2.233
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1172/JCI113369	http://dx.doi.org/10.1172/JCI113369
DOI	10.1172/JCI16997	http://dx.doi.org/10.1172/JCI16997
DOI	10.1212/01.WNL.0000118205.99701.41	http://dx.doi.org/10.1212/01.WNL.0000118205.99701.41
DrugBank	DB00674	http://www.drugbank.ca/drugs/DB00674
EMBL	AK299445	http://www.ebi.ac.uk/ena/data/view/AK299445
EMBL	CH471058	http://www.ebi.ac.uk/ena/data/view/CH471058
EMBL	CH471058	http://www.ebi.ac.uk/ena/data/view/CH471058
EMBL	S77094	http://www.ebi.ac.uk/ena/data/view/S77094
EMBL	X02502	http://www.ebi.ac.uk/ena/data/view/X02502
EMBL	X02503	http://www.ebi.ac.uk/ena/data/view/X02503
EMBL	X02504	http://www.ebi.ac.uk/ena/data/view/X02504
EMBL	X02505	http://www.ebi.ac.uk/ena/data/view/X02505
EMBL	X02506	http://www.ebi.ac.uk/ena/data/view/X02506
EMBL	X02507	http://www.ebi.ac.uk/ena/data/view/X02507
EMBL	X02508	http://www.ebi.ac.uk/ena/data/view/X02508
EMBL	X17104	http://www.ebi.ac.uk/ena/data/view/X17104
EMBL	X70108	http://www.ebi.ac.uk/ena/data/view/X70108
EMBL	Y00762	http://www.ebi.ac.uk/ena/data/view/Y00762
Ensembl	ENST00000261007	http://www.ensembl.org/id/ENST00000261007
Ensembl	ENST00000348749	http://www.ensembl.org/id/ENST00000348749
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005892	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005892
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0031594	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031594
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0004889	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004889
GO_function	GO:0005216	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005216
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_function	GO:0015464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015464
GO_function	GO:0042166	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042166
GO_process	GO:0003009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003009
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007271
GO_process	GO:0007274	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007274
GO_process	GO:0007528	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007528
GO_process	GO:0019228	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019228
GO_process	GO:0035094	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035094
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0046716	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046716
GO_process	GO:0048630	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048630
GO_process	GO:0050881	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050881
GO_process	GO:0050905	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050905
GO_process	GO:0070050	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070050
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0040007	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040007
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
Gene3D	1.20.120.370	http://www.cathdb.info/version/latest/superfamily/1.20.120.370
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	CHRNA1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CHRNA1
GeneID	1134	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1134
GeneTree	ENSGT00760000118930	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118930
HGNC	HGNC:1955	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1955
HOGENOM	HOG000006756	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006756&db=HOGENOM6
HOVERGEN	HBG003756	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003756&db=HOVERGEN
HPA	CAB010902	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB010902
HPA	HPA071554	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA071554
InParanoid	P02708	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P02708
IntAct	P02708	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P02708*
InterPro	IPR002394	http://www.ebi.ac.uk/interpro/entry/IPR002394
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
InterPro	IPR027361	http://www.ebi.ac.uk/interpro/entry/IPR027361
Jabion	1134	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1134
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00770	http://www.genome.jp/dbget-bin/www_bget?H00770
KEGG_Disease	H00986	http://www.genome.jp/dbget-bin/www_bget?H00986
KEGG_Gene	hsa:1134	http://www.genome.jp/dbget-bin/www_bget?hsa:1134
KEGG_Orthology	KO:K04803	http://www.genome.jp/dbget-bin/www_bget?KO:K04803
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
MIM	100690	http://www.ncbi.nlm.nih.gov/omim/100690
MIM	253290	http://www.ncbi.nlm.nih.gov/omim/253290
MIM	254200	http://www.ncbi.nlm.nih.gov/omim/254200
MIM	601462	http://www.ncbi.nlm.nih.gov/omim/601462
MIM	608930	http://www.ncbi.nlm.nih.gov/omim/608930
OMA	AMVMDHL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AMVMDHL
Orphanet	33108	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=33108
Orphanet	98913	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98913
OrthoDB	EOG091G0R20	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0R20
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PDB	1Y5P	http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y5P
PDB	1Y5T	http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y5T
PDB	1Y6C	http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y6C
PDB	4ZJS	http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZJS
PDBsum	1Y5P	http://www.ebi.ac.uk/pdbsum/1Y5P
PDBsum	1Y5T	http://www.ebi.ac.uk/pdbsum/1Y5T
PDBsum	1Y6C	http://www.ebi.ac.uk/pdbsum/1Y6C
PDBsum	4ZJS	http://www.ebi.ac.uk/pdbsum/4ZJS
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00254	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00254
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:ACHA_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ACHA_HUMAN
PSORT-B	swissprot:ACHA_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ACHA_HUMAN
PSORT2	swissprot:ACHA_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ACHA_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA26487	http://www.pharmgkb.org/do/serve?objId=PA26487&objCls=Gene
Phobius	swissprot:ACHA_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ACHA_HUMAN
PhylomeDB	P02708	http://phylomedb.org/?seqid=P02708
ProteinModelPortal	P02708	http://www.proteinmodelportal.org/query/uniprot/P02708
PubMed	10195214	http://www.ncbi.nlm.nih.gov/pubmed/10195214
PubMed	12588888	http://www.ncbi.nlm.nih.gov/pubmed/12588888
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15079006	http://www.ncbi.nlm.nih.gov/pubmed/15079006
PubMed	16685696	http://www.ncbi.nlm.nih.gov/pubmed/16685696
PubMed	1694127	http://www.ncbi.nlm.nih.gov/pubmed/1694127
PubMed	18252226	http://www.ncbi.nlm.nih.gov/pubmed/18252226
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	2449458	http://www.ncbi.nlm.nih.gov/pubmed/2449458
PubMed	3338555	http://www.ncbi.nlm.nih.gov/pubmed/3338555
PubMed	6688857	http://www.ncbi.nlm.nih.gov/pubmed/6688857
PubMed	7619526	http://www.ncbi.nlm.nih.gov/pubmed/7619526
PubMed	7725386	http://www.ncbi.nlm.nih.gov/pubmed/7725386
PubMed	8441631	http://www.ncbi.nlm.nih.gov/pubmed/8441631
PubMed	8872460	http://www.ncbi.nlm.nih.gov/pubmed/8872460
PubMed	9158151	http://www.ncbi.nlm.nih.gov/pubmed/9158151
PubMed	9221765	http://www.ncbi.nlm.nih.gov/pubmed/9221765
Reactome	R-HSA-629594	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-629594
Reactome	R-HSA-629597	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-629597
RefSeq	NP_000070	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000070
RefSeq	NP_001034612	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001034612
SMR	P02708	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P02708
STRING	9606.ENSP00000261007	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000261007&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TCDB	1.A.9.1	http://www.tcdb.org/search/result.php?tc=1.A.9.1
UCSC	uc002ujd	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ujd&org=rat
UniGene	Hs.434479	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.434479
UniProtKB	ACHA_HUMAN	http://www.uniprot.org/uniprot/ACHA_HUMAN
UniProtKB-AC	P02708	http://www.uniprot.org/uniprot/P02708
charge	swissprot:ACHA_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ACHA_HUMAN
eggNOG	ENOG410XQGR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQGR
eggNOG	KOG3645	http://eggnogapi.embl.de/nog_data/html/tree/KOG3645
epestfind	swissprot:ACHA_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ACHA_HUMAN
garnier	swissprot:ACHA_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ACHA_HUMAN
helixturnhelix	swissprot:ACHA_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACHA_HUMAN
hmoment	swissprot:ACHA_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ACHA_HUMAN
iep	swissprot:ACHA_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ACHA_HUMAN
inforesidue	swissprot:ACHA_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ACHA_HUMAN
neXtProt	NX_P02708	http://www.nextprot.org/db/entry/NX_P02708
octanol	swissprot:ACHA_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ACHA_HUMAN
pepcoil	swissprot:ACHA_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ACHA_HUMAN
pepdigest	swissprot:ACHA_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ACHA_HUMAN
pepinfo	swissprot:ACHA_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ACHA_HUMAN
pepnet	swissprot:ACHA_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ACHA_HUMAN
pepstats	swissprot:ACHA_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ACHA_HUMAN
pepwheel	swissprot:ACHA_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ACHA_HUMAN
pepwindow	swissprot:ACHA_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ACHA_HUMAN
sigcleave	swissprot:ACHA_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ACHA_HUMAN
## Database	ID	URL or Descriptions
# AltName	S38A3_HUMAN	N-system amino acid transporter 1
# AltName	S38A3_HUMAN	Na(+)-coupled neutral amino acid transporter 3
# AltName	S38A3_HUMAN	Solute carrier family 38 member 3
# AltName	S38A3_HUMAN	System N amino acid transporter 1
# BioGrid	116187	5
# ChiTaRS	SLC38A3	human
# DrugBank	DB00117	L-Histidine
# DrugBank	DB00130	L-Glutamine
# DrugBank	DB00174	L-Asparagine
# Ensembl	ENST00000614032	ENSP00000481301; ENSG00000188338
# ExpressionAtlas	Q99624	baseline and differential
# FUNCTION	S38A3_HUMAN	Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission. {ECO 0000250|UniProtKB Q9JHZ9, ECO 0000269|PubMed 10823827}. 
# GO_component	GO:0005886	plasma membrane; IDA:LIFEdb.
# GO_component	GO:0005887	integral component of plasma membrane; ISS:UniProtKB.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:Ensembl.
# GO_function	GO:0005290	L-histidine transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015180	L-alanine transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015182	L-asparagine transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015186	L-glutamine transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_function	GO:0015297	antiporter activity; IEA:UniProtKB-KW.
# GO_process	GO:0006814	sodium ion transport; IEA:UniProtKB-KW.
# GO_process	GO:0006865	amino acid transport; TAS:Reactome.
# GO_process	GO:0006867	asparagine transport; IDA:UniProtKB.
# GO_process	GO:0006868	glutamine transport; IDA:UniProtKB.
# GO_process	GO:0007420	brain development; IEA:Ensembl.
# GO_process	GO:0007565	female pregnancy; IEA:Ensembl.
# GO_process	GO:0015808	L-alanine transport; IDA:UniProtKB.
# GO_process	GO:0015817	histidine transport; IDA:UniProtKB.
# GO_process	GO:0051365	cellular response to potassium ion starvation; IEA:Ensembl.
# GO_process	GO:0061402	positive regulation of transcription from RNA polymerase II promoter in response to acidic pH; IEA:Ensembl.
# GO_process	GO:2000487	positive regulation of glutamine transport; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# Genevisible	Q99624	HS
# HGNC	HGNC:18044	SLC38A3
# IntAct	Q99624	3
# InterPro	IPR013057	AA_transpt_TM
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04724	Glutamatergic synapse
# KEGG_Pathway	ko04727	GABAergic synapse
# KEGG_Pathway	ko04964	Proximal tubule bicarbonate reclamation
# MIM	604437	gene
# Organism	S38A3_HUMAN	Homo sapiens (Human)
# Pfam	PF01490	Aa_trans
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-352230	Amino acid transport across the plasma membrane
# RecName	S38A3_HUMAN	Sodium-coupled neutral amino acid transporter 3
# RefSeq	NP_006832	NM_006841.5
# RefSeq	XP_006713017	XM_006712954.2
# SIMILARITY	Belongs to the amino acid/polyamine transporter 2 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S38A3_HUMAN	Cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# TCDB	2.A.18.6	the amino acid/auxin permease (aaap) family
# UCSC	uc032rmu	human
BLAST	swissprot:S38A3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S38A3_HUMAN
BioCyc	ZFISH:ENSG00000145063-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000145063-MONOMER
COXPRESdb	10991	http://coxpresdb.jp/data/gene/10991.shtml
CleanEx	HS_NAT1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_NAT1
CleanEx	HS_SLC38A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC38A3
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M002282200	http://dx.doi.org/10.1074/jbc.M002282200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DrugBank	DB00117	http://www.drugbank.ca/drugs/DB00117
DrugBank	DB00130	http://www.drugbank.ca/drugs/DB00130
DrugBank	DB00174	http://www.drugbank.ca/drugs/DB00174
EMBL	AC002077	http://www.ebi.ac.uk/ena/data/view/AC002077
EMBL	AF244548	http://www.ebi.ac.uk/ena/data/view/AF244548
EMBL	AK313461	http://www.ebi.ac.uk/ena/data/view/AK313461
EMBL	BC042875	http://www.ebi.ac.uk/ena/data/view/BC042875
EMBL	BX537382	http://www.ebi.ac.uk/ena/data/view/BX537382
EMBL	CH471055	http://www.ebi.ac.uk/ena/data/view/CH471055
EMBL	CR456970	http://www.ebi.ac.uk/ena/data/view/CR456970
EMBL	U49082	http://www.ebi.ac.uk/ena/data/view/U49082
Ensembl	ENST00000614032	http://www.ensembl.org/id/ENST00000614032
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_function	GO:0005290	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005290
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_function	GO:0015180	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015180
GO_function	GO:0015182	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015182
GO_function	GO:0015186	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015186
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_function	GO:0015297	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GO_process	GO:0006867	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006867
GO_process	GO:0006868	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006868
GO_process	GO:0007420	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007420
GO_process	GO:0007565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007565
GO_process	GO:0015808	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015808
GO_process	GO:0015817	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015817
GO_process	GO:0051365	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051365
GO_process	GO:0061402	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061402
GO_process	GO:2000487	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000487
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GeneCards	SLC38A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC38A3
GeneID	10991	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10991
GeneTree	ENSGT00760000119147	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119147
HGNC	HGNC:18044	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18044
HOVERGEN	HBG059571	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG059571&db=HOVERGEN
InParanoid	Q99624	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q99624
IntAct	Q99624	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q99624*
InterPro	IPR013057	http://www.ebi.ac.uk/interpro/entry/IPR013057
Jabion	10991	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10991
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:10991	http://www.genome.jp/dbget-bin/www_bget?hsa:10991
KEGG_Orthology	KO:K13576	http://www.genome.jp/dbget-bin/www_bget?KO:K13576
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
KEGG_Pathway	ko04964	http://www.genome.jp/kegg-bin/show_pathway?ko04964
MIM	604437	http://www.ncbi.nlm.nih.gov/omim/604437
MINT	MINT-1384272	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1384272
OMA	GHEWEYD	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GHEWEYD
OrthoDB	EOG091G0GP8	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0GP8
PSORT	swissprot:S38A3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S38A3_HUMAN
PSORT-B	swissprot:S38A3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S38A3_HUMAN
PSORT2	swissprot:S38A3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S38A3_HUMAN
Pfam	PF01490	http://pfam.xfam.org/family/PF01490
PharmGKB	PA38281	http://www.pharmgkb.org/do/serve?objId=PA38281&objCls=Gene
Phobius	swissprot:S38A3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S38A3_HUMAN
PhylomeDB	Q99624	http://phylomedb.org/?seqid=Q99624
ProteinModelPortal	Q99624	http://www.proteinmodelportal.org/query/uniprot/Q99624
PubMed	10823827	http://www.ncbi.nlm.nih.gov/pubmed/10823827
PubMed	11085536	http://www.ncbi.nlm.nih.gov/pubmed/11085536
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
Reactome	R-HSA-352230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-352230
RefSeq	NP_006832	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006832
RefSeq	XP_006713017	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006713017
TCDB	2.A.18.6	http://www.tcdb.org/search/result.php?tc=2.A.18.6
UCSC	uc032rmu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc032rmu&org=rat
UniGene	Hs.76460	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.76460
UniProtKB	S38A3_HUMAN	http://www.uniprot.org/uniprot/S38A3_HUMAN
UniProtKB-AC	Q99624	http://www.uniprot.org/uniprot/Q99624
charge	swissprot:S38A3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S38A3_HUMAN
epestfind	swissprot:S38A3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S38A3_HUMAN
garnier	swissprot:S38A3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S38A3_HUMAN
helixturnhelix	swissprot:S38A3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S38A3_HUMAN
hmoment	swissprot:S38A3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S38A3_HUMAN
iep	swissprot:S38A3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S38A3_HUMAN
inforesidue	swissprot:S38A3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S38A3_HUMAN
neXtProt	NX_Q99624	http://www.nextprot.org/db/entry/NX_Q99624
octanol	swissprot:S38A3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S38A3_HUMAN
pepcoil	swissprot:S38A3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S38A3_HUMAN
pepdigest	swissprot:S38A3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S38A3_HUMAN
pepinfo	swissprot:S38A3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S38A3_HUMAN
pepnet	swissprot:S38A3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S38A3_HUMAN
pepstats	swissprot:S38A3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S38A3_HUMAN
pepwheel	swissprot:S38A3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S38A3_HUMAN
pepwindow	swissprot:S38A3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S38A3_HUMAN
sigcleave	swissprot:S38A3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S38A3_HUMAN
## Database	ID	URL or Descriptions
# AltName	SC6A1_HUMAN	Solute carrier family 6 member 1
# BioGrid	112420	2
# ChiTaRS	SLC6A1	human
# DISEASE	SC6A1_HUMAN	Myoclonic-atonic epilepsy (MAE) [MIM 616421]  A form of epilepsy characterized by myoclonic-atonic and absence seizures, appearing in early childhood. Patients have delayed development before the onset of seizures and show varying degrees of intellectual disability following seizure onset. {ECO 0000269|PubMed 25865495}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	SC6A1_HUMAN	The PDZ domain-binding motif is involved in the interaction with MPP5. 
# DrugBank	DB00349	Clobazam
# DrugBank	DB00906	Tiagabine
# Ensembl	ENST00000287766	ENSP00000287766; ENSG00000157103
# ExpressionAtlas	P30531	baseline and differential
# FUNCTION	SC6A1_HUMAN	Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0009986	cell surface; IEA:Ensembl.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_component	GO:0030424	axon; IEA:Ensembl.
# GO_component	GO:0043005	neuron projection; IBA:GO_Central.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_function	SC6A1_HUMAN	GO 0005328 neurotransmitter sodium symporter activity; IEA InterPro.
# GO_function	SC6A1_HUMAN	GO 0005332 gamma-aminobutyric acid sodium symporter activity; IBA GO_Central.
# GO_process	GO:0006810	transport; NAS:ProtInc.
# GO_process	GO:0006836	neurotransmitter transport; IBA:GO_Central.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:ProtInc.
# GO_process	GO:0007612	learning; IEA:Ensembl.
# GO_process	GO:0009636	response to toxic substance; IEA:Ensembl.
# GO_process	GO:0009744	response to sucrose; IEA:Ensembl.
# GO_process	GO:0010288	response to lead ion; IEA:Ensembl.
# GO_process	GO:0014054	positive regulation of gamma-aminobutyric acid secretion; IEA:Ensembl.
# GO_process	GO:0014074	response to purine-containing compound; IEA:Ensembl.
# GO_process	GO:0015812	gamma-aminobutyric acid transport; IBA:GO_Central.
# GO_process	GO:0032229	negative regulation of synaptic transmission, GABAergic; IEA:Ensembl.
# GO_process	GO:0032355	response to estradiol; IEA:Ensembl.
# GO_process	GO:0042220	response to cocaine; IEA:Ensembl.
# GO_process	GO:0051260	protein homooligomerization; IEA:Ensembl.
# GO_process	GO:0051592	response to calcium ion; IEA:Ensembl.
# GO_process	GO:0051939	gamma-aminobutyric acid import; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# Genevisible	P30531	HS
# HGNC	HGNC:11042	SLC6A1
# IntAct	P30531	2
# InterPro	IPR000175	Na/ntran_symport
# InterPro	IPR002980	Na/ntran_symport_GABA_GAT1
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04727	GABAergic synapse
# MIM	137165	gene
# MIM	616421	phenotype
# MISCELLANEOUS	SC6A1_HUMAN	This protein is the target of psychomotor stimulants such as amphetamines or cocaine. 
# Organism	SC6A1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11616	PTHR11616
# PIR	S11073	S11073
# PRINTS	PR00176	NANEUSMPORT
# PRINTS	PR01195	GAT1TRNSPORT
# PROSITE	PS00610	NA_NEUROTRAN_SYMP_1
# PROSITE	PS00754	NA_NEUROTRAN_SYMP_2
# PROSITE	PS50267	NA_NEUROTRAN_SYMP_3
# Pfam	PF00209	SNF
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-442660	Na+/Cl- dependent neurotransmitter transporters
# Reactome	R-HSA-888593	Reuptake of GABA
# RecName	SC6A1_HUMAN	Sodium- and chloride-dependent GABA transporter 1
# RefSeq	NP_003033	NM_003042.3
# RefSeq	XP_005265467	XM_005265410.4
# RefSeq	XP_005265468	XM_005265411.4
# RefSeq	XP_006713369	XM_006713306.3
# RefSeq	XP_011532327	XM_011534025.2
# RefSeq	XP_011532329	XM_011534027.2
# RefSeq	XP_016862560	XM_017007071.1
# RefSeq	XP_016862561	XM_017007072.1
# SIMILARITY	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A1 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	SC6A1_HUMAN	Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons (By similarity). {ECO 0000250}. 
# SUBUNIT	Interacts with MPP5. {ECO	0000250}. 
# TCDB	2.A.22.3:the neurotransmitter	sodium symporter (nss) family
# UCSC	uc010hdq	human
# eggNOG	COG0733	LUCA
# eggNOG	KOG3659	Eukaryota
BLAST	swissprot:SC6A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SC6A1_HUMAN
BioCyc	ZFISH:ENSG00000157103-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000157103-MONOMER
COXPRESdb	6529	http://coxpresdb.jp/data/gene/6529.shtml
CleanEx	HS_SLC6A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC6A1
DOI	10.1016/0014-5793(90)81149-I	http://dx.doi.org/10.1016/0014-5793(90)81149-I
DOI	10.1016/j.ajhg.2015.02.016	http://dx.doi.org/10.1016/j.ajhg.2015.02.016
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00349	http://www.drugbank.ca/drugs/DB00349
DrugBank	DB00906	http://www.drugbank.ca/drugs/DB00906
EMBL	AC024910	http://www.ebi.ac.uk/ena/data/view/AC024910
EMBL	BC033904	http://www.ebi.ac.uk/ena/data/view/BC033904
EMBL	X54673	http://www.ebi.ac.uk/ena/data/view/X54673
Ensembl	ENST00000287766	http://www.ensembl.org/id/ENST00000287766
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030424	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030424
GO_component	GO:0043005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043005
GO_function	GO:0005328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005328
GO_function	GO:0005332	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005332
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006836	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006836
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007612	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007612
GO_process	GO:0009636	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009636
GO_process	GO:0009744	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009744
GO_process	GO:0010288	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010288
GO_process	GO:0014054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014054
GO_process	GO:0014074	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014074
GO_process	GO:0015812	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015812
GO_process	GO:0032229	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032229
GO_process	GO:0032355	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032355
GO_process	GO:0042220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042220
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:0051592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051592
GO_process	GO:0051939	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051939
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	SLC6A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC6A1
GeneID	6529	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6529
GeneTree	ENSGT00760000118857	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118857
HGNC	HGNC:11042	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11042
HOGENOM	HOG000116406	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116406&db=HOGENOM6
HOVERGEN	HBG071421	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG071421&db=HOVERGEN
HPA	CAB022293	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB022293
HPA	HPA013341	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA013341
InParanoid	P30531	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30531
IntAct	P30531	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30531*
InterPro	IPR000175	http://www.ebi.ac.uk/interpro/entry/IPR000175
InterPro	IPR002980	http://www.ebi.ac.uk/interpro/entry/IPR002980
Jabion	6529	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6529
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:6529	http://www.genome.jp/dbget-bin/www_bget?hsa:6529
KEGG_Orthology	KO:K05034	http://www.genome.jp/dbget-bin/www_bget?KO:K05034
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
MIM	137165	http://www.ncbi.nlm.nih.gov/omim/137165
MIM	616421	http://www.ncbi.nlm.nih.gov/omim/616421
OMA	NCVNQYE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NCVNQYE
OrthoDB	EOG091G08PX	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08PX
PANTHER	PTHR11616	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11616
PRINTS	PR00176	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00176
PRINTS	PR01195	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01195
PROSITE	PS00610	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00610
PROSITE	PS00754	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00754
PROSITE	PS50267	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50267
PSORT	swissprot:SC6A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SC6A1_HUMAN
PSORT-B	swissprot:SC6A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SC6A1_HUMAN
PSORT2	swissprot:SC6A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SC6A1_HUMAN
Pfam	PF00209	http://pfam.xfam.org/family/PF00209
PharmGKB	PA309	http://www.pharmgkb.org/do/serve?objId=PA309&objCls=Gene
Phobius	swissprot:SC6A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SC6A1_HUMAN
PhylomeDB	P30531	http://phylomedb.org/?seqid=P30531
ProteinModelPortal	P30531	http://www.proteinmodelportal.org/query/uniprot/P30531
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	2387399	http://www.ncbi.nlm.nih.gov/pubmed/2387399
PubMed	25865495	http://www.ncbi.nlm.nih.gov/pubmed/25865495
Reactome	R-HSA-442660	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442660
Reactome	R-HSA-888593	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-888593
RefSeq	NP_003033	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003033
RefSeq	XP_005265467	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005265467
RefSeq	XP_005265468	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005265468
RefSeq	XP_006713369	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006713369
RefSeq	XP_011532327	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011532327
RefSeq	XP_011532329	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011532329
RefSeq	XP_016862560	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016862560
RefSeq	XP_016862561	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016862561
STRING	9606.ENSP00000287766	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000287766&targetmode=cogs
TCDB	2.A.22.3	http://www.tcdb.org/search/result.php?tc=2.A.22.3
UCSC	uc010hdq	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010hdq&org=rat
UniGene	Hs.443874	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.443874
UniProtKB	SC6A1_HUMAN	http://www.uniprot.org/uniprot/SC6A1_HUMAN
UniProtKB-AC	P30531	http://www.uniprot.org/uniprot/P30531
charge	swissprot:SC6A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SC6A1_HUMAN
eggNOG	COG0733	http://eggnogapi.embl.de/nog_data/html/tree/COG0733
eggNOG	KOG3659	http://eggnogapi.embl.de/nog_data/html/tree/KOG3659
epestfind	swissprot:SC6A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SC6A1_HUMAN
garnier	swissprot:SC6A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SC6A1_HUMAN
helixturnhelix	swissprot:SC6A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SC6A1_HUMAN
hmoment	swissprot:SC6A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SC6A1_HUMAN
iep	swissprot:SC6A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SC6A1_HUMAN
inforesidue	swissprot:SC6A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SC6A1_HUMAN
neXtProt	NX_P30531	http://www.nextprot.org/db/entry/NX_P30531
octanol	swissprot:SC6A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SC6A1_HUMAN
pepcoil	swissprot:SC6A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SC6A1_HUMAN
pepdigest	swissprot:SC6A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SC6A1_HUMAN
pepinfo	swissprot:SC6A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SC6A1_HUMAN
pepnet	swissprot:SC6A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SC6A1_HUMAN
pepstats	swissprot:SC6A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SC6A1_HUMAN
pepwheel	swissprot:SC6A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SC6A1_HUMAN
pepwindow	swissprot:SC6A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SC6A1_HUMAN
sigcleave	swissprot:SC6A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SC6A1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AT5G2_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q06055-1; Sequence=Displayed; Name=2; IsoId=Q06055-2; Sequence=VSP_037348; Note=Derived from EST data.; Name=3; IsoId=Q06055-3; Sequence=VSP_037349; Note=Derived from EST data.; 
# AltName	AT5G2_HUMAN	ATP synthase lipid-binding protein
# AltName	AT5G2_HUMAN	ATP synthase proteolipid P2
# AltName	AT5G2_HUMAN	ATP synthase proton-transporting mitochondrial F(0) complex subunit C2
# AltName	AT5G2_HUMAN	ATPase protein 9
# AltName	AT5G2_HUMAN	ATPase subunit c
# BioGrid	107002	3
# CCDS	CCDS31812	-. [Q06055-3]
# CCDS	CCDS81694	-. [Q06055-1]
# CCDS	CCDS8863	-. [Q06055-2]
# ChiTaRS	ATP5G2	human
# Ensembl	ENST00000338662	ENSP00000340315; ENSG00000135390. [Q06055-3]
# Ensembl	ENST00000394349	ENSP00000377878; ENSG00000135390. [Q06055-2]
# Ensembl	ENST00000549164	ENSP00000447317; ENSG00000135390. [Q06055-1]
# Ensembl	ENST00000552242	ENSP00000448801; ENSG00000135390. [Q06055-1]
# Ensembl	ENST00000602871	ENSP00000473535; ENSG00000135390. [Q06055-1]
# ExpressionAtlas	Q06055	baseline and differential
# FUNCTION	AT5G2_HUMAN	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element. 
# GO_component	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); IBA:GO_Central.
# GO_component	GO:0005741	mitochondrial outer membrane; TAS:Reactome.
# GO_component	GO:0005753	mitochondrial proton-transporting ATP synthase complex; TAS:ProtInc.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005215	transporter activity; NAS:ProtInc.
# GO_function	GO:0008289	lipid binding; IEA:UniProtKB-KW.
# GO_function	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism; IBA:GO_Central.
# GO_process	GO:0006754	ATP biosynthetic process; TAS:Reactome.
# GO_process	GO:0015986	ATP synthesis coupled proton transport; IBA:GO_Central.
# GO_process	GO:0015991	ATP hydrolysis coupled proton transport; IEA:InterPro.
# GO_process	GO:0042776	mitochondrial ATP synthesis coupled proton transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008289	lipid binding
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.20.10	-; 1.
# Genevisible	Q06055	HS
# HAMAP	MF_01396	ATP_synth_c_bact
# HGNC	HGNC:842	ATP5G2
# IntAct	Q06055	3
# InterPro	IPR000454	ATP_synth_F0_csu
# InterPro	IPR002379	ATPase_proteolipid_c-like_dom
# InterPro	IPR020537	ATP_synth_F0_csu_DDCD_BS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	603193	gene
# MISCELLANEOUS	AT5G2_HUMAN	There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins. Is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease). 
# Organism	AT5G2_HUMAN	Homo sapiens (Human)
# PIR	S34067	S34067
# PRINTS	PR00124	ATPASEC
# PROSITE	PS00605	ATPASE_C
# Pfam	PF00137	ATP-synt_C
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-163210	Formation of ATP by chemiosmotic coupling
# RecName	AT5G2_HUMAN	ATP synthase F(0) complex subunit C2, mitochondrial
# RefSeq	NP_001002031	NM_001002031.2. [Q06055-3]
# RefSeq	NP_001317198	NM_001330269.1
# RefSeq	NP_005167	NM_005176.5. [Q06055-2]
# RefSeq	XP_016874949	XM_017019460.1. [Q06055-2]
# RefSeq	XP_016874950	XM_017019461.1. [Q06055-3]
# SIMILARITY	Belongs to the ATPase C chain family. {ECO	0000305}.
# SUBCELLULAR LOCATION	AT5G2_HUMAN	Mitochondrion membrane; Multi-pass membrane protein. 
# SUBUNIT	F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits	 a, b and c. 
# SUPFAM	SSF81333	SSF81333
# TopDownProteomics	Q06055-1	-. [Q06055-1]
# TopDownProteomics	Q06055-2	-. [Q06055-2]
# UCSC	uc001sec	human. [Q06055-1]
# eggNOG	COG0636	LUCA
# eggNOG	KOG3025	Eukaryota
BLAST	swissprot:AT5G2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AT5G2_HUMAN
BioCyc	ZFISH:HS05994-MONOMER	http://biocyc.org/getid?id=ZFISH:HS05994-MONOMER
COG	COG0636	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0636
COXPRESdb	517	http://coxpresdb.jp/data/gene/517.shtml
CleanEx	HS_ATP5G2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP5G2
DOI	10.1016/0006-291X(87)91446-X	http://dx.doi.org/10.1016/0006-291X(87)91446-X
DOI	10.1016/0167-4781(93)90249-D	http://dx.doi.org/10.1016/0167-4781(93)90249-D
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1042/bj2930051	http://dx.doi.org/10.1042/bj2930051
DOI	10.1093/dnares/12.2.117	http://dx.doi.org/10.1093/dnares/12.2.117
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC073594	http://www.ebi.ac.uk/ena/data/view/AC073594
EMBL	AK075351	http://www.ebi.ac.uk/ena/data/view/AK075351
EMBL	BC020826	http://www.ebi.ac.uk/ena/data/view/BC020826
EMBL	D13119	http://www.ebi.ac.uk/ena/data/view/D13119
EMBL	X69908	http://www.ebi.ac.uk/ena/data/view/X69908
Ensembl	ENST00000338662	http://www.ensembl.org/id/ENST00000338662
Ensembl	ENST00000394349	http://www.ensembl.org/id/ENST00000394349
Ensembl	ENST00000549164	http://www.ensembl.org/id/ENST00000549164
Ensembl	ENST00000552242	http://www.ensembl.org/id/ENST00000552242
Ensembl	ENST00000602871	http://www.ensembl.org/id/ENST00000602871
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000276
GO_component	GO:0005741	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005741
GO_component	GO:0005753	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005753
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GO_function	GO:0046933	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046933
GO_process	GO:0006754	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006754
GO_process	GO:0015986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015986
GO_process	GO:0015991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015991
GO_process	GO:0042776	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042776
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.20.10	http://www.cathdb.info/version/latest/superfamily/1.20.20.10
GeneCards	ATP5G2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP5G2
GeneID	517	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=517
GeneTree	ENSGT00390000006210	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000006210
H-InvDB	HIX0201895	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0201895
HAMAP	MF_01396	http://hamap.expasy.org/unirule/MF_01396
HGNC	HGNC:842	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:842
HOGENOM	HOG000235246	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000235246&db=HOGENOM6
HOVERGEN	HBG050605	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050605&db=HOVERGEN
HPA	HPA051469	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA051469
InParanoid	Q06055	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q06055
IntAct	Q06055	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q06055*
InterPro	IPR000454	http://www.ebi.ac.uk/interpro/entry/IPR000454
InterPro	IPR002379	http://www.ebi.ac.uk/interpro/entry/IPR002379
InterPro	IPR020537	http://www.ebi.ac.uk/interpro/entry/IPR020537
Jabion	517	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=517
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:517	http://www.genome.jp/dbget-bin/www_bget?hsa:517
KEGG_Orthology	KO:K02128	http://www.genome.jp/dbget-bin/www_bget?KO:K02128
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	603193	http://www.ncbi.nlm.nih.gov/omim/603193
OMA	HPLKMYT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HPLKMYT
OrthoDB	EOG091G13J1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G13J1
PRINTS	PR00124	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00124
PROSITE	PS00605	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00605
PSORT	swissprot:AT5G2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AT5G2_HUMAN
PSORT-B	swissprot:AT5G2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AT5G2_HUMAN
PSORT2	swissprot:AT5G2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AT5G2_HUMAN
Pfam	PF00137	http://pfam.xfam.org/family/PF00137
PharmGKB	PA25132	http://www.pharmgkb.org/do/serve?objId=PA25132&objCls=Gene
Phobius	swissprot:AT5G2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AT5G2_HUMAN
PhylomeDB	Q06055	http://phylomedb.org/?seqid=Q06055
ProteinModelPortal	Q06055	http://www.proteinmodelportal.org/query/uniprot/Q06055
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16303743	http://www.ncbi.nlm.nih.gov/pubmed/16303743
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	2883974	http://www.ncbi.nlm.nih.gov/pubmed/2883974
PubMed	8328972	http://www.ncbi.nlm.nih.gov/pubmed/8328972
PubMed	8485160	http://www.ncbi.nlm.nih.gov/pubmed/8485160
Reactome	R-HSA-163210	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-163210
RefSeq	NP_001002031	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001002031
RefSeq	NP_001317198	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001317198
RefSeq	NP_005167	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005167
RefSeq	XP_016874949	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016874949
RefSeq	XP_016874950	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016874950
STRING	9606.ENSP00000377878	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000377878&targetmode=cogs
STRING	COG0636	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0636&targetmode=cogs
SUPFAM	SSF81333	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81333
UCSC	uc001sec	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001sec&org=rat
UniGene	Hs.524464	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.524464
UniProtKB	AT5G2_HUMAN	http://www.uniprot.org/uniprot/AT5G2_HUMAN
UniProtKB-AC	Q06055	http://www.uniprot.org/uniprot/Q06055
charge	swissprot:AT5G2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AT5G2_HUMAN
eggNOG	COG0636	http://eggnogapi.embl.de/nog_data/html/tree/COG0636
eggNOG	KOG3025	http://eggnogapi.embl.de/nog_data/html/tree/KOG3025
epestfind	swissprot:AT5G2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AT5G2_HUMAN
garnier	swissprot:AT5G2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AT5G2_HUMAN
helixturnhelix	swissprot:AT5G2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AT5G2_HUMAN
hmoment	swissprot:AT5G2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AT5G2_HUMAN
iep	swissprot:AT5G2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AT5G2_HUMAN
inforesidue	swissprot:AT5G2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AT5G2_HUMAN
neXtProt	NX_Q06055	http://www.nextprot.org/db/entry/NX_Q06055
octanol	swissprot:AT5G2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AT5G2_HUMAN
pepcoil	swissprot:AT5G2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AT5G2_HUMAN
pepdigest	swissprot:AT5G2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AT5G2_HUMAN
pepinfo	swissprot:AT5G2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AT5G2_HUMAN
pepnet	swissprot:AT5G2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AT5G2_HUMAN
pepstats	swissprot:AT5G2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AT5G2_HUMAN
pepwheel	swissprot:AT5G2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AT5G2_HUMAN
pepwindow	swissprot:AT5G2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AT5G2_HUMAN
sigcleave	swissprot:AT5G2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AT5G2_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	117724	25
# ChiTaRS	TIMM9	human
# DOMAIN	TIM9_HUMAN	The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM9 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (Probable). {ECO 0000305}. 
# Ensembl	ENST00000395159	ENSP00000378588; ENSG00000100575
# Ensembl	ENST00000555061	ENSP00000450638; ENSG00000100575
# Ensembl	ENST00000555404	ENSP00000451198; ENSG00000100575
# Ensembl	ENST00000555593	ENSP00000451006; ENSG00000100575
# ExpressionAtlas	Q9Y5J7	baseline and differential
# FUNCTION	TIM9_HUMAN	Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. {ECO 0000269|PubMed 14726512}. 
# GO_component	GO:0005739	mitochondrion; IDA:HPA.
# GO_component	GO:0005743	mitochondrial inner membrane; IDA:BHF-UCL.
# GO_component	GO:0005758	mitochondrial intermembrane space; TAS:BHF-UCL.
# GO_component	GO:0042719	mitochondrial intermembrane space protein transporter complex; IDA:BHF-UCL.
# GO_component	GO:0042721	mitochondrial inner membrane protein insertion complex; IBA:GO_Central.
# GO_function	GO:0005215	transporter activity; IDA:BHF-UCL.
# GO_function	GO:0008270	zinc ion binding; TAS:ProtInc.
# GO_function	GO:0008565	protein transporter activity; IBA:GO_Central.
# GO_function	GO:0042803	protein homodimerization activity; IPI:BHF-UCL.
# GO_function	GO:0051087	chaperone binding; IPI:BHF-UCL.
# GO_process	GO:0006626	protein targeting to mitochondrion; TAS:Reactome.
# GO_process	GO:0007605	sensory perception of sound; TAS:ProtInc.
# GO_process	GO:0045039	protein import into mitochondrial inner membrane; IDA:BHF-UCL.
# GO_process	GO:0072321	chaperone-mediated protein transport; IDA:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006605	protein targeting
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007005	mitochondrion organization
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# GOslim_process	GO:0061024	membrane organization
# Gene3D	1.10.287.810	-; 1.
# Genevisible	Q9Y5J7	HS
# HGNC	HGNC:11819	TIMM9
# INTERACTION	TIM9_HUMAN	P62072 TIMM10; NbExp=4; IntAct=EBI-1200370, EBI-1200391; 
# IntAct	Q9Y5J7	5
# InterPro	IPR004217	Tim10/DDP_fam_Znf
# MIM	607384	gene
# Organism	TIM9_HUMAN	Homo sapiens (Human)
# PDB	2BSK	X-ray; 3.30 A; A/C/E=1-89
# PIR	T51191	T51191
# Pfam	PF02953	zf-Tim10_DDP
# Proteomes	UP000005640	Chromosome 14
# Reactome	R-HSA-1268020	Mitochondrial protein import
# RecName	TIM9_HUMAN	Mitochondrial import inner membrane translocase subunit Tim9
# RefSeq	NP_001291414	NM_001304485.1
# RefSeq	NP_001291415	NM_001304486.1
# RefSeq	NP_001291416	NM_001304487.1
# RefSeq	NP_001291417	NM_001304488.1
# RefSeq	NP_001291418	NM_001304489.1
# RefSeq	NP_001291419	NM_001304490.1
# RefSeq	NP_001291420	NM_001304491.1
# RefSeq	NP_036592	NM_012460.3
# SIMILARITY	Belongs to the small Tim family. {ECO	0000305}.
# SUBCELLULAR LOCATION	TIM9_HUMAN	Mitochondrion inner membrane {ECO 0000269|PubMed 11489896, ECO 0000269|PubMed 14726512}; Peripheral membrane protein {ECO 0000269|PubMed 11489896, ECO 0000269|PubMed 14726512}; Intermembrane side {ECO 0000269|PubMed 11489896, ECO 0000269|PubMed 14726512}. 
# SUBUNIT	TIM9_HUMAN	Heterohexamer; composed of 3 copies of TIMM9 and 3 copies of TIMM10/TIM10A, named soluble 70 kDa complex. The complex forms a 6-bladed alpha-propeller structure and associates with the TIMM22 component of the TIM22 complex. Interacts with multi-pass transmembrane proteins in transit. Also forms a complex composed of TIMM9, TIMM10/TIM10A and FXC1/TIM10B. {ECO 0000269|PubMed 14726512, ECO 0000269|PubMed 16387659}. 
# SUPFAM	SSF144122	SSF144122
# TISSUE SPECIFICITY	TIM9_HUMAN	Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle. {ECO 0000269|PubMed 10552927, ECO 0000269|PubMed 10611480}. 
# UCSC	uc001xds	human
# eggNOG	ENOG4111TUA	LUCA
# eggNOG	KOG3479	Eukaryota
BLAST	swissprot:TIM9_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TIM9_HUMAN
BioCyc	ZFISH:ENSG00000100575-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000100575-MONOMER
COXPRESdb	26520	http://coxpresdb.jp/data/gene/26520.shtml
CleanEx	HS_TIMM9	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TIMM9
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/geno.1999.5966	http://dx.doi.org/10.1006/geno.1999.5966
DOI	10.1016/S0014-5793(99)01665-8	http://dx.doi.org/10.1016/S0014-5793(99)01665-8
DOI	10.1016/j.molcel.2005.11.010	http://dx.doi.org/10.1016/j.molcel.2005.11.010
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M105313200	http://dx.doi.org/10.1074/jbc.M105313200
DOI	10.1074/jbc.M312485200	http://dx.doi.org/10.1074/jbc.M312485200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF150100	http://www.ebi.ac.uk/ena/data/view/AF150100
EMBL	AF152353	http://www.ebi.ac.uk/ena/data/view/AF152353
EMBL	AK312095	http://www.ebi.ac.uk/ena/data/view/AK312095
EMBL	BC020213	http://www.ebi.ac.uk/ena/data/view/BC020213
EMBL	BC054875	http://www.ebi.ac.uk/ena/data/view/BC054875
EMBL	CH471061	http://www.ebi.ac.uk/ena/data/view/CH471061
Ensembl	ENST00000395159	http://www.ensembl.org/id/ENST00000395159
Ensembl	ENST00000555061	http://www.ensembl.org/id/ENST00000555061
Ensembl	ENST00000555404	http://www.ensembl.org/id/ENST00000555404
Ensembl	ENST00000555593	http://www.ensembl.org/id/ENST00000555593
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005758	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005758
GO_component	GO:0042719	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042719
GO_component	GO:0042721	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042721
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0008270	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_function	GO:0051087	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051087
GO_process	GO:0006626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006626
GO_process	GO:0007605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007605
GO_process	GO:0045039	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045039
GO_process	GO:0072321	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072321
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007005
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
Gene3D	1.10.287.810	http://www.cathdb.info/version/latest/superfamily/1.10.287.810
GeneCards	TIMM9	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TIMM9
GeneID	26520	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26520
GeneTree	ENSGT00450000040278	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00450000040278
HGNC	HGNC:11819	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11819
HOVERGEN	HBG083156	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG083156&db=HOVERGEN
HPA	HPA002932	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA002932
InParanoid	Q9Y5J7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y5J7
IntAct	Q9Y5J7	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9Y5J7*
InterPro	IPR004217	http://www.ebi.ac.uk/interpro/entry/IPR004217
Jabion	26520	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=26520
KEGG_Gene	hsa:26520	http://www.genome.jp/dbget-bin/www_bget?hsa:26520
MIM	607384	http://www.ncbi.nlm.nih.gov/omim/607384
OMA	SNLVERC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SNLVERC
OrthoDB	EOG091G10NM	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G10NM
PDB	2BSK	http://www.ebi.ac.uk/pdbe-srv/view/entry/2BSK
PDBsum	2BSK	http://www.ebi.ac.uk/pdbsum/2BSK
PSORT	swissprot:TIM9_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TIM9_HUMAN
PSORT-B	swissprot:TIM9_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TIM9_HUMAN
PSORT2	swissprot:TIM9_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TIM9_HUMAN
Pfam	PF02953	http://pfam.xfam.org/family/PF02953
PharmGKB	PA36525	http://www.pharmgkb.org/do/serve?objId=PA36525&objCls=Gene
Phobius	swissprot:TIM9_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TIM9_HUMAN
PhylomeDB	Q9Y5J7	http://phylomedb.org/?seqid=Q9Y5J7
ProteinModelPortal	Q9Y5J7	http://www.proteinmodelportal.org/query/uniprot/Q9Y5J7
PubMed	10552927	http://www.ncbi.nlm.nih.gov/pubmed/10552927
PubMed	10611480	http://www.ncbi.nlm.nih.gov/pubmed/10611480
PubMed	11489896	http://www.ncbi.nlm.nih.gov/pubmed/11489896
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	14726512	http://www.ncbi.nlm.nih.gov/pubmed/14726512
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16387659	http://www.ncbi.nlm.nih.gov/pubmed/16387659
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-1268020	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1268020
RefSeq	NP_001291414	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001291414
RefSeq	NP_001291415	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001291415
RefSeq	NP_001291416	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001291416
RefSeq	NP_001291417	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001291417
RefSeq	NP_001291418	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001291418
RefSeq	NP_001291419	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001291419
RefSeq	NP_001291420	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001291420
RefSeq	NP_036592	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_036592
SMR	Q9Y5J7	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9Y5J7
STRING	9606.ENSP00000378588	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000378588&targetmode=cogs
SUPFAM	SSF144122	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF144122
UCSC	uc001xds	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001xds&org=rat
UniGene	Hs.440525	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.440525
UniProtKB	TIM9_HUMAN	http://www.uniprot.org/uniprot/TIM9_HUMAN
UniProtKB-AC	Q9Y5J7	http://www.uniprot.org/uniprot/Q9Y5J7
charge	swissprot:TIM9_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TIM9_HUMAN
eggNOG	ENOG4111TUA	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111TUA
eggNOG	KOG3479	http://eggnogapi.embl.de/nog_data/html/tree/KOG3479
epestfind	swissprot:TIM9_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TIM9_HUMAN
garnier	swissprot:TIM9_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TIM9_HUMAN
helixturnhelix	swissprot:TIM9_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TIM9_HUMAN
hmoment	swissprot:TIM9_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TIM9_HUMAN
iep	swissprot:TIM9_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TIM9_HUMAN
inforesidue	swissprot:TIM9_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TIM9_HUMAN
neXtProt	NX_Q9Y5J7	http://www.nextprot.org/db/entry/NX_Q9Y5J7
octanol	swissprot:TIM9_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TIM9_HUMAN
pepcoil	swissprot:TIM9_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TIM9_HUMAN
pepdigest	swissprot:TIM9_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TIM9_HUMAN
pepinfo	swissprot:TIM9_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TIM9_HUMAN
pepnet	swissprot:TIM9_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TIM9_HUMAN
pepstats	swissprot:TIM9_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TIM9_HUMAN
pepwheel	swissprot:TIM9_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TIM9_HUMAN
pepwindow	swissprot:TIM9_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TIM9_HUMAN
sigcleave	swissprot:TIM9_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TIM9_HUMAN
## Database	ID	URL or Descriptions
# AltName	LAT1_HUMAN	4F2 light chain
# AltName	LAT1_HUMAN	CD98 light chain
# AltName	LAT1_HUMAN	Integral membrane protein E16
# AltName	LAT1_HUMAN	L-type amino acid transporter 1
# AltName	LAT1_HUMAN	Solute carrier family 7 member 5
# AltName	LAT1_HUMAN	y+ system cationic amino acid transporter
# BIOPHYSICOCHEMICAL PROPERTIES	LAT1_HUMAN	Kinetic parameters  KM=7.9 uM for T4 (in the presence of choline chloride) {ECO 0000269|PubMed 10574970, ECO 0000269|PubMed 11564694, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 12225859, ECO 0000269|PubMed 18262359}; KM=0.8 uM for T3 (in the presence of choline chloride) {ECO 0000269|PubMed 10574970, ECO 0000269|PubMed 11564694, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 12225859, ECO 0000269|PubMed 18262359}; KM=12.5 uM for reverse triiodothyronine (rT3) (in the presence of choline chloride) {ECO 0000269|PubMed 10574970, ECO 0000269|PubMed 11564694, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 12225859, ECO 0000269|PubMed 18262359}; KM=7.9 uM for 3,3'-diiodothyronine (in the presence of choline chloride) {ECO 0000269|PubMed 10574970, ECO 0000269|PubMed 11564694, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 12225859, ECO 0000269|PubMed 18262359}; KM=46 uM for leucine (in the presence of choline chloride) {ECO 0000269|PubMed 10574970, ECO 0000269|PubMed 11564694, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 12225859, ECO 0000269|PubMed 18262359}; KM=19 uM for tryptophan (in the presence of choline chloride) {ECO 0000269|PubMed 10574970, ECO 0000269|PubMed 11564694, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 12225859, ECO 0000269|PubMed 18262359}; KM=32 uM for L-leucine {ECO 0000269|PubMed 10574970, ECO 0000269|PubMed 11564694, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 12225859, ECO 0000269|PubMed 18262359}; KM=10 mM for L-alanine {ECO 0000269|PubMed 10574970, ECO 0000269|PubMed 11564694, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 12225859, ECO 0000269|PubMed 18262359}; KM=2.2 mM for L-glutamine {ECO 0000269|PubMed 10574970, ECO 0000269|PubMed 11564694, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 12225859, ECO 0000269|PubMed 18262359}; KM=35 uM for L-histidine {ECO 0000269|PubMed 10574970, ECO 0000269|PubMed 11564694, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 12225859, ECO 0000269|PubMed 18262359}; KM=740 uM for L-phenylalanine {ECO 0000269|PubMed 10574970, ECO 0000269|PubMed 11564694, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 12225859, ECO 0000269|PubMed 18262359}; KM=98 uM for MeHg-L-cysteine {ECO 0000269|PubMed 10574970, ECO 0000269|PubMed 11564694, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 12225859, ECO 0000269|PubMed 18262359}; KM=99 uM for methionine {ECO 0000269|PubMed 10574970, ECO 0000269|PubMed 11564694, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 12225859, ECO 0000269|PubMed 18262359}; KM=55.2 uM for phenylalanine (in T24 human bladder carcinoma cells) {ECO 0000269|PubMed 10574970, ECO 0000269|PubMed 11564694, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 12225859, ECO 0000269|PubMed 18262359}; KM=60.4 uM for tyrosine (in T24 human bladder carcinoma cells) {ECO 0000269|PubMed 10574970, ECO 0000269|PubMed 11564694, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 12225859, ECO 0000269|PubMed 18262359}; KM=16.4 uM for tyrosine (in human fibroblasts) {ECO 0000269|PubMed 10574970, ECO 0000269|PubMed 11564694, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 12225859, ECO 0000269|PubMed 18262359}; KM=138 uM for Dopa (in T24 human bladder carcinoma cells) {ECO 0000269|PubMed 10574970, ECO 0000269|PubMed 11564694, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 12225859, ECO 0000269|PubMed 18262359}; KM=96.5 uM for 3-O-methyldopa (in T24 human bladder carcinoma cells) {ECO 0000269|PubMed 10574970, ECO 0000269|PubMed 11564694, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 12225859, ECO 0000269|PubMed 18262359}; KM=153 uM for alpha-methyltyrosine (in T24 human bladder carcinoma cells) {ECO 0000269|PubMed 10574970, ECO 0000269|PubMed 11564694, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 12225859, ECO 0000269|PubMed 18262359}; KM=216 uM for alpha-methyldopa (in T24 human bladder carcinoma cells) {ECO 0000269|PubMed 10574970, ECO 0000269|PubMed 11564694, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 12225859, ECO 0000269|PubMed 18262359}; KM=191 uM for gabapentin (in T24 human bladder carcinoma cells) {ECO 0000269|PubMed 10574970, ECO 0000269|PubMed 11564694, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 12225859, ECO 0000269|PubMed 18262359}; KM=7.3 uM for triiodothyronine (in T24 human bladder carcinoma cells) {ECO 0000269|PubMed 10574970, ECO 0000269|PubMed 11564694, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 12225859, ECO 0000269|PubMed 18262359}; KM=162 uM for thyroxine (in T24 human bladder carcinoma cells) {ECO 0000269|PubMed 10574970, ECO 0000269|PubMed 11564694, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 12225859, ECO 0000269|PubMed 18262359}; KM=75.3 uM for melphanan (in T24 human bladder carcinoma cells) {ECO 0000269|PubMed 10574970, ECO 0000269|PubMed 11564694, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 12225859, ECO 0000269|PubMed 18262359}; KM=156 uM for BCH (in T24 human bladder carcinoma cells) {ECO 0000269|PubMed 10574970, ECO 0000269|PubMed 11564694, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 12225859, ECO 0000269|PubMed 18262359}; 
# BioGrid	113801	15
# ChiTaRS	SLC7A5	human
# DrugBank	DB00279	Liothyronine
# DrugBank	DB00451	Levothyroxine
# DrugBank	DB00509	Dextrothyroxine
# DrugBank	DB01042	Melphalan
# DrugBank	DB01235	Levodopa
# Ensembl	ENST00000261622	ENSP00000261622; ENSG00000103257
# ExpressionAtlas	Q01650	baseline and differential
# FUNCTION	LAT1_HUMAN	Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood- brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L- leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina. Acts as the major transporter of tyrosine in fibroblasts. {ECO 0000269|PubMed 10049700, ECO 0000269|PubMed 10391915, ECO 0000269|PubMed 10574970, ECO 0000269|PubMed 11311135, ECO 0000269|PubMed 11389679, ECO 0000269|PubMed 11557028, ECO 0000269|PubMed 11564694, ECO 0000269|PubMed 11742812, ECO 0000269|PubMed 12117417, ECO 0000269|PubMed 12225859, ECO 0000269|PubMed 15769744, ECO 0000269|PubMed 16496379, ECO 0000269|PubMed 18262359, ECO 0000269|PubMed 9751058}. 
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0005829	cytosol; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; IDA:HPA.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; ISS:UniProtKB.
# GO_function	GO:0015175	neutral amino acid transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0015179	L-amino acid transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015297	antiporter activity; IBA:GO_Central.
# GO_function	GO:0042605	peptide antigen binding; ISS:UniProtKB.
# GO_process	GO:0006520	cellular amino acid metabolic process; TAS:ProtInc.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006865	amino acid transport; TAS:Reactome.
# GO_process	GO:0007399	nervous system development; IEA:UniProtKB-KW.
# GO_process	GO:0015804	neutral amino acid transport; ISS:UniProtKB.
# GO_process	GO:0030154	cell differentiation; IEA:UniProtKB-KW.
# GO_process	GO:0050900	leukocyte migration; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006520	cellular amino acid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0048870	cell motility
# Genevisible	Q01650	HS
# HGNC	HGNC:11063	SLC7A5
# INDUCTION	LAT1_HUMAN	Expression induced in quiescent peripheral blood lymphocytes after treatment with phorbol myristate acetate (PMA) and phytohemagglutinin (PHA). Expression and the uptake of leucine is stimulated in mononuclear, cytotrophoblast-like choriocarcinoma cells by combined treatment with PMA and calcium ionophore. {ECO 0000269|PubMed 11742812, ECO 0000269|PubMed 1597461}. 
# IntAct	Q01650	19
# InterPro	IPR002293	AA/rel_permease1
# InterPro	IPR004760	L_AA_transporter
# KEGG_Brite	ko02001	Solute carrier family
# MIM	600182	gene
# MISCELLANEOUS	LAT1_HUMAN	The uptake of leucine, tyrosine and tryptophan is inhibited by the different iodothyronines, in particular T3. Leucine transport is also inhibited by small zwitterionic amino acids (i.e. glycine, alanine, serine, threonine and cysteine) and by glutamine and asparginine. The uptake of T3 is almost completely blocked by coincubation with leucine, tryptophan, tyrosine, and phenylalanine, or 2-amino-bicyclo-(2,2,1)-heptane-2- carboxylate (BCH). Methionine uptake was inhibited by the L-system substrates L-leucine, BCH, L-cysteine and by the MeHg-L-cysteine complex and structurally related S-ethyl-L-cysteine. MeHg-L- cysteine uptake is inhibited by L-methionine, L-leucine, BCH and S-ethyl-L-cysteine. L-leucine uptake was inhibited by L-CNSO. Tyrosine uptake in fibroblasts was inhibited by D-methionine, and methyl-aminoisobutyric acid (MeAIB). 
# Organism	LAT1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11785	PTHR11785
# PIR	JG0165	JG0165
# PIRSF	PIRSF006060	AA_transporter
# Pfam	PF13520	AA_permease_2
# Proteomes	UP000005640	Chromosome 16
# Reactome	R-HSA-210991	Basigin interactions
# Reactome	R-HSA-352230	Amino acid transport across the plasma membrane
# RecName	LAT1_HUMAN	Large neutral amino acids transporter small subunit 1
# RefSeq	NP_003477	NM_003486.6
# SIMILARITY	Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	LAT1_HUMAN	Cytoplasm, cytosol. Apical cell membrane; Multi-pass membrane protein. Note=Located to the plasma membrane by SLC3A2/4F2hc. Localized to the apical membrane of placental syncytiophoblastic cells. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity). {ECO 0000250}. 
# SUBUNIT	LAT1_HUMAN	Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc. {ECO 0000269|PubMed 10049700, ECO 0000269|PubMed 11311135, ECO 0000269|PubMed 11389679, ECO 0000269|PubMed 11557028, ECO 0000269|PubMed 11564694, ECO 0000269|PubMed 12225859, ECO 0000269|PubMed 15769744, ECO 0000269|PubMed 9751058}. 
# TCDB	2.A.3.8.25	the amino acid-polyamine-organocation (apc) family
# TIGRFAMs	TIGR00911	2A0308
# TISSUE SPECIFICITY	LAT1_HUMAN	Expressed abundantly in adult lung, liver, brain, skeletal muscle, placenta, bone marrow, testis, resting lymphocytes and monocytes, and in fetal liver. Weaker expression in thymus, cornea, retina, peripheral leukocytes, spleen, kidney, colon and lymph node. During gestation, expression in the placenta was significantly stronger at full-term than at the mid-trimester stage. Also expressed in all human tumor cell lines tested and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco-2. {ECO 0000269|PubMed 10049700, ECO 0000269|PubMed 10072483, ECO 0000269|PubMed 11389679, ECO 0000269|PubMed 11557028, ECO 0000269|PubMed 11742812, ECO 0000269|PubMed 12824232, ECO 0000269|PubMed 1597461, ECO 0000269|PubMed 16027961, ECO 0000269|PubMed 16496379}. 
# UCSC	uc002fkm	human
# eggNOG	COG0531	LUCA
# eggNOG	KOG1287	Eukaryota
BLAST	swissprot:LAT1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:LAT1_HUMAN
BioCyc	MetaCyc:ENSG00000103257-MONOMER	http://biocyc.org/getid?id=MetaCyc:ENSG00000103257-MONOMER
BioCyc	ZFISH:ENSG00000103257-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000103257-MONOMER
COXPRESdb	8140	http://coxpresdb.jp/data/gene/8140.shtml
CleanEx	HS_SLC7A5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC7A5
DOI	10.1002/ijc.21866	http://dx.doi.org/10.1002/ijc.21866
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/bbrc.1999.0206	http://dx.doi.org/10.1006/bbrc.1999.0206
DOI	10.1007/s00726-005-0221-x	http://dx.doi.org/10.1007/s00726-005-0221-x
DOI	10.1016/S0005-2736(01)00384-4	http://dx.doi.org/10.1016/S0005-2736(01)00384-4
DOI	10.1016/S0005-2736(02)00516-3	http://dx.doi.org/10.1016/S0005-2736(02)00516-3
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1016/j.neulet.2008.01.028	http://dx.doi.org/10.1016/j.neulet.2008.01.028
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/26246	http://dx.doi.org/10.1038/26246
DOI	10.1042/0264-6021:3560719	http://dx.doi.org/10.1042/0264-6021:3560719
DOI	10.1042/BJ20020841	http://dx.doi.org/10.1042/BJ20020841
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/jbc.274.28.19738	http://dx.doi.org/10.1074/jbc.274.28.19738
DOI	10.1074/jbc.274.49.34948	http://dx.doi.org/10.1074/jbc.274.49.34948
DOI	10.1074/jbc.M413164200	http://dx.doi.org/10.1074/jbc.M413164200
DOI	10.1074/mcp.M800588-MCP200	http://dx.doi.org/10.1074/mcp.M800588-MCP200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1167/iovs.02-0907	http://dx.doi.org/10.1167/iovs.02-0907
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1210/en.142.10.4339	http://dx.doi.org/10.1210/en.142.10.4339
DrugBank	DB00279	http://www.drugbank.ca/drugs/DB00279
DrugBank	DB00451	http://www.drugbank.ca/drugs/DB00451
DrugBank	DB00509	http://www.drugbank.ca/drugs/DB00509
DrugBank	DB01042	http://www.drugbank.ca/drugs/DB01042
DrugBank	DB01235	http://www.drugbank.ca/drugs/DB01235
EMBL	AB017908	http://www.ebi.ac.uk/ena/data/view/AB017908
EMBL	AB018009	http://www.ebi.ac.uk/ena/data/view/AB018009
EMBL	AB018542	http://www.ebi.ac.uk/ena/data/view/AB018542
EMBL	AF077866	http://www.ebi.ac.uk/ena/data/view/AF077866
EMBL	AF104032	http://www.ebi.ac.uk/ena/data/view/AF104032
EMBL	BC039692	http://www.ebi.ac.uk/ena/data/view/BC039692
EMBL	BC042600	http://www.ebi.ac.uk/ena/data/view/BC042600
EMBL	M80244	http://www.ebi.ac.uk/ena/data/view/M80244
Ensembl	ENST00000261622	http://www.ensembl.org/id/ENST00000261622
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_function	GO:0015175	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015175
GO_function	GO:0015179	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015179
GO_function	GO:0015297	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297
GO_function	GO:0042605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042605
GO_process	GO:0006520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GO_process	GO:0007399	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007399
GO_process	GO:0015804	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015804
GO_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GO_process	GO:0050900	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050900
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GeneCards	SLC7A5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC7A5
GeneID	8140	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8140
GeneTree	ENSGT00760000119037	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119037
HGNC	HGNC:11063	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11063
HOGENOM	HOG000098892	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000098892&db=HOGENOM6
HOVERGEN	HBG000476	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000476&db=HOVERGEN
HPA	HPA052673	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA052673
HPA	HPA056077	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA056077
InParanoid	Q01650	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q01650
IntAct	Q01650	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q01650*
InterPro	IPR002293	http://www.ebi.ac.uk/interpro/entry/IPR002293
InterPro	IPR004760	http://www.ebi.ac.uk/interpro/entry/IPR004760
Jabion	8140	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=8140
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:8140	http://www.genome.jp/dbget-bin/www_bget?hsa:8140
KEGG_Orthology	KO:K13780	http://www.genome.jp/dbget-bin/www_bget?KO:K13780
MIM	600182	http://www.ncbi.nlm.nih.gov/omim/600182
MINT	MINT-5000558	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5000558
OMA	MIWLRHR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MIWLRHR
OrthoDB	EOG091G07EM	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07EM
PANTHER	PTHR11785	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785
PSORT	swissprot:LAT1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:LAT1_HUMAN
PSORT-B	swissprot:LAT1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:LAT1_HUMAN
PSORT2	swissprot:LAT1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:LAT1_HUMAN
Pfam	PF13520	http://pfam.xfam.org/family/PF13520
PharmGKB	PA35923	http://www.pharmgkb.org/do/serve?objId=PA35923&objCls=Gene
Phobius	swissprot:LAT1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:LAT1_HUMAN
PhylomeDB	Q01650	http://phylomedb.org/?seqid=Q01650
ProteinModelPortal	Q01650	http://www.proteinmodelportal.org/query/uniprot/Q01650
PubMed	10049700	http://www.ncbi.nlm.nih.gov/pubmed/10049700
PubMed	10072483	http://www.ncbi.nlm.nih.gov/pubmed/10072483
PubMed	10391915	http://www.ncbi.nlm.nih.gov/pubmed/10391915
PubMed	10574970	http://www.ncbi.nlm.nih.gov/pubmed/10574970
PubMed	11311135	http://www.ncbi.nlm.nih.gov/pubmed/11311135
PubMed	11389679	http://www.ncbi.nlm.nih.gov/pubmed/11389679
PubMed	11557028	http://www.ncbi.nlm.nih.gov/pubmed/11557028
PubMed	11564694	http://www.ncbi.nlm.nih.gov/pubmed/11564694
PubMed	11742812	http://www.ncbi.nlm.nih.gov/pubmed/11742812
PubMed	12117417	http://www.ncbi.nlm.nih.gov/pubmed/12117417
PubMed	12225859	http://www.ncbi.nlm.nih.gov/pubmed/12225859
PubMed	12824232	http://www.ncbi.nlm.nih.gov/pubmed/12824232
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15769744	http://www.ncbi.nlm.nih.gov/pubmed/15769744
PubMed	1597461	http://www.ncbi.nlm.nih.gov/pubmed/1597461
PubMed	16027961	http://www.ncbi.nlm.nih.gov/pubmed/16027961
PubMed	16496379	http://www.ncbi.nlm.nih.gov/pubmed/16496379
PubMed	18262359	http://www.ncbi.nlm.nih.gov/pubmed/18262359
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	19369195	http://www.ncbi.nlm.nih.gov/pubmed/19369195
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	9751058	http://www.ncbi.nlm.nih.gov/pubmed/9751058
Reactome	R-HSA-210991	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-210991
Reactome	R-HSA-352230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-352230
RefSeq	NP_003477	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003477
STRING	9606.ENSP00000261622	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000261622&targetmode=cogs
TCDB	2.A.3.8.25	http://www.tcdb.org/search/result.php?tc=2.A.3.8.25
TIGRFAMs	TIGR00911	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00911
UCSC	uc002fkm	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002fkm&org=rat
UniGene	Hs.513797	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.513797
UniProtKB	LAT1_HUMAN	http://www.uniprot.org/uniprot/LAT1_HUMAN
UniProtKB-AC	Q01650	http://www.uniprot.org/uniprot/Q01650
charge	swissprot:LAT1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:LAT1_HUMAN
eggNOG	COG0531	http://eggnogapi.embl.de/nog_data/html/tree/COG0531
eggNOG	KOG1287	http://eggnogapi.embl.de/nog_data/html/tree/KOG1287
epestfind	swissprot:LAT1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:LAT1_HUMAN
garnier	swissprot:LAT1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:LAT1_HUMAN
helixturnhelix	swissprot:LAT1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:LAT1_HUMAN
hmoment	swissprot:LAT1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:LAT1_HUMAN
iep	swissprot:LAT1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:LAT1_HUMAN
inforesidue	swissprot:LAT1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:LAT1_HUMAN
neXtProt	NX_Q01650	http://www.nextprot.org/db/entry/NX_Q01650
octanol	swissprot:LAT1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:LAT1_HUMAN
pepcoil	swissprot:LAT1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:LAT1_HUMAN
pepdigest	swissprot:LAT1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:LAT1_HUMAN
pepinfo	swissprot:LAT1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:LAT1_HUMAN
pepnet	swissprot:LAT1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:LAT1_HUMAN
pepstats	swissprot:LAT1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:LAT1_HUMAN
pepwheel	swissprot:LAT1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:LAT1_HUMAN
pepwindow	swissprot:LAT1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:LAT1_HUMAN
sigcleave	swissprot:LAT1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:LAT1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ACHA2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q15822-1; Sequence=Displayed; Name=2; IsoId=Q15822-2; Sequence=VSP_055156; Note=No experimental confirmation available.; 
# CCDS	CCDS6059	-. [Q15822-1]
# CCDS	CCDS64856	-. [Q15822-2]
# ChiTaRS	CHRNA2	human
# DISEASE	ACHA2_HUMAN	Epilepsy, nocturnal frontal lobe, 4 (ENFL4) [MIM 610353]  An autosomal dominant focal epilepsy characterized by nocturnal seizures associated with fear sensation, tongue movements, and nocturnal wandering, closely resembling nightmares and sleep walking. {ECO 0000269|PubMed 16826524}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00184	Nicotine
# DrugBank	DB00411	Carbachol
# DrugBank	DB00483	Gallamine Triethiodide
# DrugBank	DB00514	Dextromethorphan
# DrugBank	DB00565	Cisatracurium besylate
# DrugBank	DB00657	Mecamylamine
# DrugBank	DB00674	Galantamine
# DrugBank	DB00721	Procaine
# DrugBank	DB00728	Rocuronium
# DrugBank	DB00732	Atracurium besylate
# DrugBank	DB00810	Biperiden
# DrugBank	DB00898	Ethanol
# DrugBank	DB01135	Doxacurium chloride
# DrugBank	DB01199	Tubocurarine
# DrugBank	DB01226	Mivacurium
# DrugBank	DB01245	Decamethonium
# DrugBank	DB01336	Metocurine
# DrugBank	DB01337	Pancuronium
# DrugBank	DB01338	Pipecuronium
# DrugBank	DB01339	Vecuronium
# Ensembl	ENST00000240132	ENSP00000240132; ENSG00000120903. [Q15822-2]
# Ensembl	ENST00000407991	ENSP00000385026; ENSG00000120903. [Q15822-1]
# ExpressionAtlas	Q15822	baseline and differential
# FUNCTION	ACHA2_HUMAN	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005892	acetylcholine-gated channel complex; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0004889	acetylcholine-activated cation-selective channel activity; IDA:UniProtKB.
# GO_function	GO:0008144	drug binding; IEA:Ensembl.
# GO_function	GO:0015276	ligand-gated ion channel activity; TAS:Reactome.
# GO_function	GO:0015464	acetylcholine receptor activity; IDA:UniProtKB.
# GO_function	GO:0042166	acetylcholine binding; IEA:Ensembl.
# GO_process	GO:0006811	ion transport; NAS:UniProtKB.
# GO_process	GO:0007165	signal transduction; IDA:UniProtKB.
# GO_process	GO:0007271	synaptic transmission, cholinergic; IBA:GO_Central.
# GO_process	GO:0007274	neuromuscular synaptic transmission; IBA:GO_Central.
# GO_process	GO:0035094	response to nicotine; IBA:GO_Central.
# GO_process	GO:0051291	protein heterooligomerization; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.20.120.370	-; 2.
# Gene3D	2.70.170.10	-; 1.
# Genevisible	Q15822	HS
# HGNC	HGNC:1956	CHRNA2
# InterPro	IPR002394	Nicotinic_acetylcholine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# InterPro	IPR027361	Acetylcholine_rcpt_TM
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00807	[Nervous system disease] Nocturnal frontal lobe epilepsy (NFLE)
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# MIM	118502	gene
# MIM	610353	phenotype
# Organism	ACHA2_HUMAN	Homo sapiens (Human)
# Orphanet	98784	Autosomal dominant nocturnal frontal lobe epilepsy
# PANTHER	PTHR18945	PTHR18945; 2
# PDB	5FJV	X-ray; 3.20 A; A/B/C/D/E=59-265
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00254	NICOTINICR
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-629594	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
# Reactome	R-HSA-629597	Highly calcium permeable nicotinic acetylcholine receptors
# RecName	ACHA2_HUMAN	Neuronal acetylcholine receptor subunit alpha-2
# RefSeq	NP_000733	NM_000742.3. [Q15822-1]
# RefSeq	NP_001269384	NM_001282455.1. [Q15822-2]
# RefSeq	XP_006716345	XM_006716282.1. [Q15822-1]
# RefSeq	XP_011542690	XM_011544388.1. [Q15822-1]
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 2/CHRNA2 sub-subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	ACHA2_HUMAN	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Neuronal AChR seems to be composed of two different types of subunits	 alpha and non-alpha (beta). Alpha-2 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TIGRFAMs	TIGR00860	LIC
# UCSC	uc010lur	human. [Q15822-1]
# eggNOG	ENOG410XQGR	LUCA
# eggNOG	KOG3645	Eukaryota
BLAST	swissprot:ACHA2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ACHA2_HUMAN
BioCyc	ZFISH:ENSG00000120903-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000120903-MONOMER
COXPRESdb	1135	http://coxpresdb.jp/data/gene/1135.shtml
CleanEx	HS_CHRNA2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CHRNA2
DOI	10.1007/BF02736842	http://dx.doi.org/10.1007/BF02736842
DOI	10.1038/nature04406	http://dx.doi.org/10.1038/nature04406
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1086/506459	http://dx.doi.org/10.1086/506459
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/epi.12967	http://dx.doi.org/10.1111/epi.12967
DrugBank	DB00184	http://www.drugbank.ca/drugs/DB00184
DrugBank	DB00411	http://www.drugbank.ca/drugs/DB00411
DrugBank	DB00483	http://www.drugbank.ca/drugs/DB00483
DrugBank	DB00514	http://www.drugbank.ca/drugs/DB00514
DrugBank	DB00565	http://www.drugbank.ca/drugs/DB00565
DrugBank	DB00657	http://www.drugbank.ca/drugs/DB00657
DrugBank	DB00674	http://www.drugbank.ca/drugs/DB00674
DrugBank	DB00721	http://www.drugbank.ca/drugs/DB00721
DrugBank	DB00728	http://www.drugbank.ca/drugs/DB00728
DrugBank	DB00732	http://www.drugbank.ca/drugs/DB00732
DrugBank	DB00810	http://www.drugbank.ca/drugs/DB00810
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01135	http://www.drugbank.ca/drugs/DB01135
DrugBank	DB01199	http://www.drugbank.ca/drugs/DB01199
DrugBank	DB01226	http://www.drugbank.ca/drugs/DB01226
DrugBank	DB01245	http://www.drugbank.ca/drugs/DB01245
DrugBank	DB01336	http://www.drugbank.ca/drugs/DB01336
DrugBank	DB01337	http://www.drugbank.ca/drugs/DB01337
DrugBank	DB01338	http://www.drugbank.ca/drugs/DB01338
DrugBank	DB01339	http://www.drugbank.ca/drugs/DB01339
EMBL	AF311103	http://www.ebi.ac.uk/ena/data/view/AF311103
EMBL	AK296348	http://www.ebi.ac.uk/ena/data/view/AK296348
EMBL	BC153866	http://www.ebi.ac.uk/ena/data/view/BC153866
EMBL	U62431	http://www.ebi.ac.uk/ena/data/view/U62431
EMBL	Y16281	http://www.ebi.ac.uk/ena/data/view/Y16281
Ensembl	ENST00000240132	http://www.ensembl.org/id/ENST00000240132
Ensembl	ENST00000407991	http://www.ensembl.org/id/ENST00000407991
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005892	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005892
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0004889	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004889
GO_function	GO:0008144	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008144
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_function	GO:0015464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015464
GO_function	GO:0042166	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042166
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007271
GO_process	GO:0007274	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007274
GO_process	GO:0035094	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035094
GO_process	GO:0051291	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051291
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.20.120.370	http://www.cathdb.info/version/latest/superfamily/1.20.120.370
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	CHRNA2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CHRNA2
GeneID	1135	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1135
GeneTree	ENSGT00760000118930	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118930
H-InvDB	HIX0034372	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0034372
HGNC	HGNC:1956	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1956
HOGENOM	HOG000006756	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006756&db=HOGENOM6
HOVERGEN	HBG003756	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003756&db=HOVERGEN
InParanoid	Q15822	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q15822
InterPro	IPR002394	http://www.ebi.ac.uk/interpro/entry/IPR002394
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
InterPro	IPR027361	http://www.ebi.ac.uk/interpro/entry/IPR027361
Jabion	1135	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1135
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00807	http://www.genome.jp/dbget-bin/www_bget?H00807
KEGG_Gene	hsa:1135	http://www.genome.jp/dbget-bin/www_bget?hsa:1135
KEGG_Orthology	KO:K04804	http://www.genome.jp/dbget-bin/www_bget?KO:K04804
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
MIM	118502	http://www.ncbi.nlm.nih.gov/omim/118502
MIM	610353	http://www.ncbi.nlm.nih.gov/omim/610353
OMA	HIETIWI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HIETIWI
Orphanet	98784	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98784
OrthoDB	EOG091G0R20	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0R20
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PDB	5FJV	http://www.ebi.ac.uk/pdbe-srv/view/entry/5FJV
PDBsum	5FJV	http://www.ebi.ac.uk/pdbsum/5FJV
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00254	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00254
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:ACHA2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ACHA2_HUMAN
PSORT-B	swissprot:ACHA2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ACHA2_HUMAN
PSORT2	swissprot:ACHA2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ACHA2_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA26489	http://www.pharmgkb.org/do/serve?objId=PA26489&objCls=Gene
Phobius	swissprot:ACHA2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ACHA2_HUMAN
PhylomeDB	Q15822	http://phylomedb.org/?seqid=Q15822
ProteinModelPortal	Q15822	http://www.proteinmodelportal.org/query/uniprot/Q15822
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16421571	http://www.ncbi.nlm.nih.gov/pubmed/16421571
PubMed	16826524	http://www.ncbi.nlm.nih.gov/pubmed/16826524
PubMed	25847220	http://www.ncbi.nlm.nih.gov/pubmed/25847220
PubMed	8906617	http://www.ncbi.nlm.nih.gov/pubmed/8906617
Reactome	R-HSA-629594	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-629594
Reactome	R-HSA-629597	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-629597
RefSeq	NP_000733	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000733
RefSeq	NP_001269384	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269384
RefSeq	XP_006716345	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006716345
RefSeq	XP_011542690	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011542690
SMR	Q15822	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q15822
STRING	9606.ENSP00000385026	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000385026&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc010lur	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010lur&org=rat
UniGene	Hs.57718	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.57718
UniProtKB	ACHA2_HUMAN	http://www.uniprot.org/uniprot/ACHA2_HUMAN
UniProtKB-AC	Q15822	http://www.uniprot.org/uniprot/Q15822
charge	swissprot:ACHA2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ACHA2_HUMAN
eggNOG	ENOG410XQGR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQGR
eggNOG	KOG3645	http://eggnogapi.embl.de/nog_data/html/tree/KOG3645
epestfind	swissprot:ACHA2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ACHA2_HUMAN
garnier	swissprot:ACHA2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ACHA2_HUMAN
helixturnhelix	swissprot:ACHA2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACHA2_HUMAN
hmoment	swissprot:ACHA2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ACHA2_HUMAN
iep	swissprot:ACHA2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ACHA2_HUMAN
inforesidue	swissprot:ACHA2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ACHA2_HUMAN
neXtProt	NX_Q15822	http://www.nextprot.org/db/entry/NX_Q15822
octanol	swissprot:ACHA2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ACHA2_HUMAN
pepcoil	swissprot:ACHA2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ACHA2_HUMAN
pepdigest	swissprot:ACHA2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ACHA2_HUMAN
pepinfo	swissprot:ACHA2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ACHA2_HUMAN
pepnet	swissprot:ACHA2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ACHA2_HUMAN
pepstats	swissprot:ACHA2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ACHA2_HUMAN
pepwheel	swissprot:ACHA2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ACHA2_HUMAN
pepwindow	swissprot:ACHA2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ACHA2_HUMAN
sigcleave	swissprot:ACHA2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ACHA2_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	123839	14
# CDD	cd00051	EFh; 2
# ChiTaRS	NCALD	human
# Ensembl	ENST00000220931	ENSP00000220931; ENSG00000104490
# Ensembl	ENST00000311028	ENSP00000310587; ENSG00000104490
# Ensembl	ENST00000395923	ENSP00000379256; ENSG00000104490
# Ensembl	ENST00000519508	ENSP00000430476; ENSG00000104490
# Ensembl	ENST00000521599	ENSP00000428105; ENSG00000104490
# ExpressionAtlas	P61601	baseline and differential
# FUNCTION	NCALD_HUMAN	May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions. 
# GO_component	GO:0005622	intracellular; IDA:LIFEdb.
# GO_component	GO:0005829	cytosol; NAS:UniProtKB.
# GO_component	GO:0030130	clathrin coat of trans-Golgi network vesicle; NAS:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0003779	actin binding; IDA:UniProtKB.
# GO_function	GO:0005509	calcium ion binding; IEA:InterPro.
# GO_function	GO:0015276	ligand-gated ion channel activity; TAS:Reactome.
# GO_function	GO:0015631	tubulin binding; IDA:UniProtKB.
# GO_function	GO:0030276	clathrin binding; IDA:UniProtKB.
# GO_process	GO:0003073	regulation of systemic arterial blood pressure; IEA:Ensembl.
# GO_process	GO:0016192	vesicle-mediated transport; NAS:UniProtKB.
# GO_process	GO:0019722	calcium-mediated signaling; IEA:Ensembl.
# GOslim_component	GO:0005622	intracellular
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008092	cytoskeletal protein binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# Gene3D	1.10.238.10	-; 3.
# Genevisible	P61601	HS
# HGNC	HGNC:7655	NCALD
# INTERACTION	NCALD_HUMAN	Q9BXJ5 C1QTNF2; NbExp=8; IntAct=EBI-749635, EBI-2817707; Q4ZH49 DTX2; NbExp=5; IntAct=EBI-749635, EBI-10192429; Q86UW9 DTX2; NbExp=7; IntAct=EBI-749635, EBI-740376; A4D127 MEOX2; NbExp=3; IntAct=EBI-749635, EBI-10172134; Q7DB77 tir (xeno); NbExp=3; IntAct=EBI-749635, EBI-6480811; 
# IntAct	P61601	7
# InterPro	IPR002048	EF_hand_dom
# InterPro	IPR011992	EF-hand-dom_pair
# InterPro	IPR018247	EF_Hand_1_Ca_BS
# InterPro	IPR028846	Recoverin
# MIM	606722	gene
# Organism	NCALD_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR23055	PTHR23055
# PROSITE	PS00018	EF_HAND_1; 3
# PROSITE	PS50222	EF_HAND_2; 4
# Pfam	PF13499	EF-hand_7
# Pfam	PF13833	EF-hand_8
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-451308	Activation of Ca-permeable Kainate Receptor
# RecName	NCALD_HUMAN	Neurocalcin-delta
# RefSeq	NP_001035714	NM_001040624.1
# RefSeq	NP_001035715	NM_001040625.1
# RefSeq	NP_001035716	NM_001040626.1
# RefSeq	NP_001035717	NM_001040627.1
# RefSeq	NP_001035718	NM_001040628.1
# RefSeq	NP_001035719	NM_001040629.1
# RefSeq	NP_001035720	NM_001040630.1
# RefSeq	NP_114430	NM_032041.2
# RefSeq	XP_011515634	XM_011517332.2
# RefSeq	XP_011515635	XM_011517333.2
# RefSeq	XP_011515636	XM_011517334.2
# RefSeq	XP_011515637	XM_011517335.2
# RefSeq	XP_016869390	XM_017013901.1
# RefSeq	XP_016869391	XM_017013902.1
# SIMILARITY	Belongs to the recoverin family. {ECO	0000305}. 
# SIMILARITY	Contains 4 EF-hand domains. {ECO:0000255|PROSITE- ProRule	PRU00448}.
# SMART	SM00054	EFh; 3
# SUPFAM	SSF47473	SSF47473
# TISSUE SPECIFICITY	NCALD_HUMAN	Retina, cerebrum, cerebellum, brain stem, spinal cord, testis, ovary and small intestine. 
# UCSC	uc003yke	human
# eggNOG	COG5126	LUCA
# eggNOG	KOG0044	Eukaryota
BLAST	swissprot:NCALD_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NCALD_HUMAN
BioCyc	ZFISH:ENSG00000104490-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000104490-MONOMER
COXPRESdb	83988	http://coxpresdb.jp/data/gene/83988.shtml
CleanEx	HS_NCALD	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_NCALD
DOI	10.1016/S0167-4781(00)00290-6	http://dx.doi.org/10.1016/S0167-4781(00)00290-6
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1101/gr.GR1547R	http://dx.doi.org/10.1101/gr.GR1547R
EMBL	AF251061	http://www.ebi.ac.uk/ena/data/view/AF251061
EMBL	AL136612	http://www.ebi.ac.uk/ena/data/view/AL136612
EMBL	BC036098	http://www.ebi.ac.uk/ena/data/view/BC036098
EMBL	BC063428	http://www.ebi.ac.uk/ena/data/view/BC063428
Ensembl	ENST00000220931	http://www.ensembl.org/id/ENST00000220931
Ensembl	ENST00000311028	http://www.ensembl.org/id/ENST00000311028
Ensembl	ENST00000395923	http://www.ensembl.org/id/ENST00000395923
Ensembl	ENST00000519508	http://www.ensembl.org/id/ENST00000519508
Ensembl	ENST00000521599	http://www.ensembl.org/id/ENST00000521599
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0030130	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030130
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0003779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003779
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_function	GO:0015631	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015631
GO_function	GO:0030276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030276
GO_process	GO:0003073	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003073
GO_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GO_process	GO:0019722	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019722
GOslim_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
Gene3D	1.10.238.10	http://www.cathdb.info/version/latest/superfamily/1.10.238.10
GeneCards	NCALD	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=NCALD
GeneID	83988	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83988
GeneTree	ENSGT00760000118820	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118820
HGNC	HGNC:7655	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:7655
HOGENOM	HOG000233019	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233019&db=HOGENOM6
HOVERGEN	HBG108179	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108179&db=HOVERGEN
HPA	HPA043245	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA043245
InParanoid	P61601	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P61601
IntAct	P61601	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P61601*
InterPro	IPR002048	http://www.ebi.ac.uk/interpro/entry/IPR002048
InterPro	IPR011992	http://www.ebi.ac.uk/interpro/entry/IPR011992
InterPro	IPR018247	http://www.ebi.ac.uk/interpro/entry/IPR018247
InterPro	IPR028846	http://www.ebi.ac.uk/interpro/entry/IPR028846
Jabion	83988	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=83988
KEGG_Gene	hsa:83988	http://www.genome.jp/dbget-bin/www_bget?hsa:83988
MIM	606722	http://www.ncbi.nlm.nih.gov/omim/606722
MINT	MINT-1436083	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1436083
OMA	ATEFNEH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ATEFNEH
PANTHER	PTHR23055	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23055
PROSITE	PS00018	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00018
PROSITE	PS50222	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50222
PSORT	swissprot:NCALD_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NCALD_HUMAN
PSORT-B	swissprot:NCALD_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NCALD_HUMAN
PSORT2	swissprot:NCALD_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NCALD_HUMAN
Pfam	PF13499	http://pfam.xfam.org/family/PF13499
Pfam	PF13833	http://pfam.xfam.org/family/PF13833
PharmGKB	PA31458	http://www.pharmgkb.org/do/serve?objId=PA31458&objCls=Gene
Phobius	swissprot:NCALD_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NCALD_HUMAN
PhylomeDB	P61601	http://phylomedb.org/?seqid=P61601
ProteinModelPortal	P61601	http://www.proteinmodelportal.org/query/uniprot/P61601
PubMed	11230166	http://www.ncbi.nlm.nih.gov/pubmed/11230166
PubMed	11267673	http://www.ncbi.nlm.nih.gov/pubmed/11267673
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-451308	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-451308
RefSeq	NP_001035714	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001035714
RefSeq	NP_001035715	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001035715
RefSeq	NP_001035716	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001035716
RefSeq	NP_001035717	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001035717
RefSeq	NP_001035718	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001035718
RefSeq	NP_001035719	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001035719
RefSeq	NP_001035720	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001035720
RefSeq	NP_114430	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_114430
RefSeq	XP_011515634	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011515634
RefSeq	XP_011515635	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011515635
RefSeq	XP_011515636	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011515636
RefSeq	XP_011515637	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011515637
RefSeq	XP_016869390	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016869390
RefSeq	XP_016869391	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016869391
SMART	SM00054	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00054
SMR	P61601	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P61601
STRING	9606.ENSP00000220931	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000220931&targetmode=cogs
SUPFAM	SSF47473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47473
UCSC	uc003yke	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003yke&org=rat
UniGene	Hs.492427	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.492427
UniProtKB	NCALD_HUMAN	http://www.uniprot.org/uniprot/NCALD_HUMAN
UniProtKB-AC	P61601	http://www.uniprot.org/uniprot/P61601
charge	swissprot:NCALD_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NCALD_HUMAN
eggNOG	COG5126	http://eggnogapi.embl.de/nog_data/html/tree/COG5126
eggNOG	KOG0044	http://eggnogapi.embl.de/nog_data/html/tree/KOG0044
epestfind	swissprot:NCALD_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NCALD_HUMAN
garnier	swissprot:NCALD_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NCALD_HUMAN
helixturnhelix	swissprot:NCALD_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NCALD_HUMAN
hmoment	swissprot:NCALD_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NCALD_HUMAN
iep	swissprot:NCALD_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NCALD_HUMAN
inforesidue	swissprot:NCALD_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NCALD_HUMAN
neXtProt	NX_P61601	http://www.nextprot.org/db/entry/NX_P61601
octanol	swissprot:NCALD_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NCALD_HUMAN
pepcoil	swissprot:NCALD_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NCALD_HUMAN
pepdigest	swissprot:NCALD_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NCALD_HUMAN
pepinfo	swissprot:NCALD_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NCALD_HUMAN
pepnet	swissprot:NCALD_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NCALD_HUMAN
pepstats	swissprot:NCALD_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NCALD_HUMAN
pepwheel	swissprot:NCALD_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NCALD_HUMAN
pepwindow	swissprot:NCALD_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NCALD_HUMAN
sigcleave	swissprot:NCALD_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NCALD_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AQP7_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O14520-1; Sequence=Displayed; Name=2; IsoId=O14520-2; Sequence=VSP_056249, VSP_056250; 
# AltName	AQP7_HUMAN	Aquaglyceroporin-7
# AltName	AQP7_HUMAN	Aquaporin adipose
# AltName	AQP7_HUMAN	Aquaporin-7-like
# CCDS	CCDS6541	-. [O14520-1]
# CDD	cd00333	MIP
# DOMAIN	AQP7_HUMAN	Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro/Ala-Ala/Ser (NPA). 
# Ensembl	ENST00000297988	ENSP00000297988; ENSG00000165269. [O14520-1]
# Ensembl	ENST00000447660	ENSP00000412868; ENSG00000165269. [O14520-2]
# ExpressionAtlas	O14520	baseline and differential
# FUNCTION	AQP7_HUMAN	Forms a channel for water and glycerol. 
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0005911	cell-cell junction; IDA:UniProtKB.
# GO_function	GO:0015204	urea transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015250	water channel activity; EXP:Reactome.
# GO_function	GO:0015254	glycerol channel activity; EXP:Reactome.
# GO_process	GO:0006091	generation of precursor metabolites and energy; TAS:ProtInc.
# GO_process	GO:0006833	water transport; TAS:Reactome.
# GO_process	GO:0007588	excretion; TAS:ProtInc.
# GO_process	GO:0009992	cellular water homeostasis; IBA:GO_Central.
# GO_process	GO:0015793	glycerol transport; TAS:Reactome.
# GO_process	GO:0034220	ion transmembrane transport; IBA:GO_Central.
# GO_process	GO:0071918	urea transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.1080.10	-; 1.
# Genevisible	O14520	HS
# HGNC	HGNC:640	AQP7
# InterPro	IPR000425	MIP
# InterPro	IPR015686	Aquaporin_7
# InterPro	IPR023271	Aquaporin-like
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko03320	PPAR signaling pathway
# MIM	602974	gene
# MIM	614411	phenotype
# Organism	AQP7_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR19139	PTHR19139
# PANTHER	PTHR19139:SF16	PTHR19139:SF16
# PIR	JC5791	JC5791
# POLYMORPHISM	Genetic variations in AQP7 are responsible for changes in glycerol release during exercise and define the glycerol quantitative trait locus (GLYCQTL) [MIM	614411]. 
# PRINTS	PR00783	MINTRINSICP
# Pfam	PF00230	MIP
# Proteomes	UP000005640	Chromosome 9
# Reactome	R-HSA-432030	Transport of glycerol from adipocytes to the liver by Aquaporins
# Reactome	R-HSA-432047	Passive transport by Aquaporins
# RecName	AQP7_HUMAN	Aquaporin-7
# RefSeq	NP_001161	NM_001170.2. [O14520-1]
# RefSeq	NP_001305086	NM_001318157.1
# RefSeq	NP_001305087	NM_001318158.1
# RefSeq	XP_005251510	XM_005251453.3. [O14520-1]
# RefSeq	XP_011516168	XM_011517866.2. [O14520-1]
# SIMILARITY	Belongs to the MIP/aquaporin (TC 1.A.8) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	AQP7_HUMAN	Membrane; Multi-pass membrane protein. 
# SUPFAM	SSF81338	SSF81338
# TCDB	1.A.8.9	the major intrinsic protein (mip) family
# TIGRFAMs	TIGR00861	MIP
# UCSC	uc003zst	human. [O14520-1]
# eggNOG	COG0580	LUCA
# eggNOG	KOG0224	Eukaryota
BLAST	swissprot:AQP7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AQP7_HUMAN
BioCyc	ZFISH:ENSG00000165269-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000165269-MONOMER
COXPRESdb	364	http://coxpresdb.jp/data/gene/364.shtml
CleanEx	HS_AQP7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AQP7
CleanEx	HS_AQP9	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AQP9
DOI	10.1006/bbrc.1997.7769	http://dx.doi.org/10.1006/bbrc.1997.7769
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1046/j.1432-1033.2002.02821.x	http://dx.doi.org/10.1046/j.1432-1033.2002.02821.x
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1210/jc.2007-0531	http://dx.doi.org/10.1210/jc.2007-0531
EMBL	AB006190	http://www.ebi.ac.uk/ena/data/view/AB006190
EMBL	AB052626	http://www.ebi.ac.uk/ena/data/view/AB052626
EMBL	AK300716	http://www.ebi.ac.uk/ena/data/view/AK300716
EMBL	AK315879	http://www.ebi.ac.uk/ena/data/view/AK315879
EMBL	AL356218	http://www.ebi.ac.uk/ena/data/view/AL356218
EMBL	BC119672	http://www.ebi.ac.uk/ena/data/view/BC119672
EMBL	BC119673	http://www.ebi.ac.uk/ena/data/view/BC119673
Ensembl	ENST00000297988	http://www.ensembl.org/id/ENST00000297988
Ensembl	ENST00000447660	http://www.ensembl.org/id/ENST00000447660
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0005911	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005911
GO_function	GO:0015204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015204
GO_function	GO:0015250	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015250
GO_function	GO:0015254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015254
GO_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GO_process	GO:0006833	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006833
GO_process	GO:0007588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007588
GO_process	GO:0009992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009992
GO_process	GO:0015793	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015793
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0071918	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071918
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.1080.10	http://www.cathdb.info/version/latest/superfamily/1.20.1080.10
GeneCards	AQP7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=AQP7
GeneID	364	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=364
GeneTree	ENSGT00510000046311	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00510000046311
H-InvDB	HIX0008072	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0008072
H-InvDB	HIX0034850	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0034850
H-InvDB	HIX0034865	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0034865
HGNC	HGNC:640	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:640
HOVERGEN	HBG106057	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG106057&db=HOVERGEN
InParanoid	O14520	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O14520
InterPro	IPR000425	http://www.ebi.ac.uk/interpro/entry/IPR000425
InterPro	IPR015686	http://www.ebi.ac.uk/interpro/entry/IPR015686
InterPro	IPR023271	http://www.ebi.ac.uk/interpro/entry/IPR023271
Jabion	364	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=364
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:364	http://www.genome.jp/dbget-bin/www_bget?hsa:364
KEGG_Orthology	KO:K08771	http://www.genome.jp/dbget-bin/www_bget?KO:K08771
KEGG_Pathway	ko03320	http://www.genome.jp/kegg-bin/show_pathway?ko03320
MIM	602974	http://www.ncbi.nlm.nih.gov/omim/602974
MIM	614411	http://www.ncbi.nlm.nih.gov/omim/614411
OMA	YLGAIIY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YLGAIIY
OrthoDB	EOG091G0FMS	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0FMS
PANTHER	PTHR19139	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19139
PANTHER	PTHR19139:SF16	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19139:SF16
PRINTS	PR00783	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00783
PSORT	swissprot:AQP7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AQP7_HUMAN
PSORT-B	swissprot:AQP7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AQP7_HUMAN
PSORT2	swissprot:AQP7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AQP7_HUMAN
Pfam	PF00230	http://pfam.xfam.org/family/PF00230
PharmGKB	PA24925	http://www.pharmgkb.org/do/serve?objId=PA24925&objCls=Gene
Phobius	swissprot:AQP7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AQP7_HUMAN
PhylomeDB	O14520	http://phylomedb.org/?seqid=O14520
ProteinModelPortal	O14520	http://www.proteinmodelportal.org/query/uniprot/O14520
PubMed	11952783	http://www.ncbi.nlm.nih.gov/pubmed/11952783
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17566090	http://www.ncbi.nlm.nih.gov/pubmed/17566090
PubMed	9405233	http://www.ncbi.nlm.nih.gov/pubmed/9405233
Reactome	R-HSA-432030	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432030
Reactome	R-HSA-432047	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432047
RefSeq	NP_001161	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001161
RefSeq	NP_001305086	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001305086
RefSeq	NP_001305087	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001305087
RefSeq	XP_005251510	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005251510
RefSeq	XP_011516168	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011516168
STRING	9606.ENSP00000297988	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000297988&targetmode=cogs
SUPFAM	SSF81338	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81338
TCDB	1.A.8.9	http://www.tcdb.org/search/result.php?tc=1.A.8.9
TIGRFAMs	TIGR00861	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00861
UCSC	uc003zst	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003zst&org=rat
UniGene	Hs.455323	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.455323
UniProtKB	AQP7_HUMAN	http://www.uniprot.org/uniprot/AQP7_HUMAN
UniProtKB-AC	O14520	http://www.uniprot.org/uniprot/O14520
charge	swissprot:AQP7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AQP7_HUMAN
eggNOG	COG0580	http://eggnogapi.embl.de/nog_data/html/tree/COG0580
eggNOG	KOG0224	http://eggnogapi.embl.de/nog_data/html/tree/KOG0224
epestfind	swissprot:AQP7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AQP7_HUMAN
garnier	swissprot:AQP7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AQP7_HUMAN
helixturnhelix	swissprot:AQP7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AQP7_HUMAN
hmoment	swissprot:AQP7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AQP7_HUMAN
iep	swissprot:AQP7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AQP7_HUMAN
inforesidue	swissprot:AQP7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AQP7_HUMAN
neXtProt	NX_O14520	http://www.nextprot.org/db/entry/NX_O14520
octanol	swissprot:AQP7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AQP7_HUMAN
pepcoil	swissprot:AQP7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AQP7_HUMAN
pepdigest	swissprot:AQP7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AQP7_HUMAN
pepinfo	swissprot:AQP7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AQP7_HUMAN
pepnet	swissprot:AQP7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AQP7_HUMAN
pepstats	swissprot:AQP7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AQP7_HUMAN
pepwheel	swissprot:AQP7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AQP7_HUMAN
pepwindow	swissprot:AQP7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AQP7_HUMAN
sigcleave	swissprot:AQP7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AQP7_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CAC1E_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Alpha-1E; IsoId=Q15878-1; Sequence=Displayed; Name=2; Synonyms=Alpha-1E-1; IsoId=Q15878-2; Sequence=VSP_000937, VSP_024817; Name=3; Synonyms=Alpha-1E-3; IsoId=Q15878-3; Sequence=VSP_024817; 
# AltName	CAC1E_HUMAN	Brain calcium channel II
# AltName	CAC1E_HUMAN	Calcium channel, L type, alpha-1 polypeptide, isoform 6
# AltName	CAC1E_HUMAN	Voltage-gated calcium channel subunit alpha Cav2.3
# BioGrid	107231	2
# CCDS	CCDS53443	-. [Q15878-3]
# CCDS	CCDS55664	-. [Q15878-1]
# CCDS	CCDS55665	-. [Q15878-2]
# ChiTaRS	CACNA1E	human
# DOMAIN	CAC1E_HUMAN	Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position. 
# Ensembl	ENST00000358338	ENSP00000351101; ENSG00000198216. [Q15878-2]
# Ensembl	ENST00000367567	ENSP00000356539; ENSG00000198216. [Q15878-3]
# Ensembl	ENST00000367570	ENSP00000356542; ENSG00000198216. [Q15878-3]
# Ensembl	ENST00000367573	ENSP00000356545; ENSG00000198216. [Q15878-1]
# Ensembl	ENST00000621551	ENSP00000483914; ENSG00000198216. [Q15878-1]
# Ensembl	ENST00000621791	ENSP00000481619; ENSG00000198216. [Q15878-2]
# ExpressionAtlas	Q15878	baseline and differential
# FUNCTION	CAC1E_HUMAN	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega- conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega- Aga-IVA). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005891	voltage-gated calcium channel complex; TAS:ProtInc.
# GO_function	GO:0005245	voltage-gated calcium channel activity; IDA:MGI.
# GO_function	GO:0005262	calcium channel activity; TAS:Reactome.
# GO_function	GO:0005509	calcium ion binding; IEA:InterPro.
# GO_function	GO:0008331	high voltage-gated calcium channel activity; IBA:GO_Central.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:ProtInc.
# GO_process	GO:0050796	regulation of insulin secretion; TAS:Reactome.
# GO_process	GO:0051899	membrane depolarization; TAS:Reactome.
# GO_process	GO:0086010	membrane depolarization during action potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.20.120.350	-; 4.
# Genevisible	Q15878	HS
# HGNC	HGNC:1392	CACNA1E
# InterPro	IPR002048	EF_hand_dom
# InterPro	IPR002077	VDCCAlpha1
# InterPro	IPR005449	VDCC_R_a1su
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR014873	VDCC_a1su_IQ
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR031649	GPHH_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04010	MAPK signaling pathway
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04930	Type II diabetes mellitus
# MIM	601013	gene
# Organism	CAC1E_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10037:SF57	PTHR10037:SF57; 3
# PDB	3BXL	X-ray; 2.30 A; B=1867-1887
# PIR	A54972	A54972
# PIR	B54972	B54972
# PRINTS	PR00167	CACHANNEL
# PRINTS	PR01633	RVDCCALPHA1
# PROSITE	PS50222	EF_HAND_2
# Pfam	PF00520	Ion_trans; 4
# Pfam	PF08763	Ca_chan_IQ
# Pfam	PF16905	GPHH
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-112308	Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
# Reactome	R-HSA-422356	Regulation of insulin secretion
# RecName	CAC1E_HUMAN	Voltage-dependent R-type calcium channel subunit alpha-1E
# RefSeq	NP_000712	NM_000721.3. [Q15878-3]
# RefSeq	NP_001192222	NM_001205293.1. [Q15878-1]
# RefSeq	NP_001192223	NM_001205294.1. [Q15878-2]
# SIMILARITY	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1E subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 EF-hand domain. {ECO:0000255|PROSITE- ProRule	PRU00448}.
# SMART	SM01062	Ca_chan_IQ
# SUBCELLULAR LOCATION	CAC1E_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	CAC1E_HUMAN	Interacts with EFHC1. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1 1 1 1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. {ECO 0000269|PubMed 15258581}. 
# TISSUE SPECIFICITY	CAC1E_HUMAN	Expressed in neuronal tissues and in kidney. 
# UCSC	uc001gow	human. [Q15878-1]
# eggNOG	ENOG410INF5	Eukaryota
# eggNOG	ENOG410YD06	LUCA
BLAST	swissprot:CAC1E_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CAC1E_HUMAN
BioCyc	ZFISH:G66-32618-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32618-MONOMER
COXPRESdb	777	http://coxpresdb.jp/data/gene/777.shtml
CleanEx	HS_CACNA1E	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CACNA1E
DOI	10.1016/j.str.2008.01.011	http://dx.doi.org/10.1016/j.str.2008.01.011
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1393	http://dx.doi.org/10.1038/ng1393
EMBL	AL160059	http://www.ebi.ac.uk/ena/data/view/AL160059
EMBL	AL160059	http://www.ebi.ac.uk/ena/data/view/AL160059
EMBL	AL160059	http://www.ebi.ac.uk/ena/data/view/AL160059
EMBL	AL160059	http://www.ebi.ac.uk/ena/data/view/AL160059
EMBL	AL160059	http://www.ebi.ac.uk/ena/data/view/AL160059
EMBL	AL160059	http://www.ebi.ac.uk/ena/data/view/AL160059
EMBL	AL160059	http://www.ebi.ac.uk/ena/data/view/AL160059
EMBL	AL160059	http://www.ebi.ac.uk/ena/data/view/AL160059
EMBL	AL160059	http://www.ebi.ac.uk/ena/data/view/AL160059
EMBL	AL160059	http://www.ebi.ac.uk/ena/data/view/AL160059
EMBL	AL160059	http://www.ebi.ac.uk/ena/data/view/AL160059
EMBL	AL160059	http://www.ebi.ac.uk/ena/data/view/AL160059
EMBL	AL161734	http://www.ebi.ac.uk/ena/data/view/AL161734
EMBL	AL161734	http://www.ebi.ac.uk/ena/data/view/AL161734
EMBL	AL161734	http://www.ebi.ac.uk/ena/data/view/AL161734
EMBL	AL161734	http://www.ebi.ac.uk/ena/data/view/AL161734
EMBL	AL161734	http://www.ebi.ac.uk/ena/data/view/AL161734
EMBL	AL161734	http://www.ebi.ac.uk/ena/data/view/AL161734
EMBL	AL161734	http://www.ebi.ac.uk/ena/data/view/AL161734
EMBL	AL161734	http://www.ebi.ac.uk/ena/data/view/AL161734
EMBL	AL161734	http://www.ebi.ac.uk/ena/data/view/AL161734
EMBL	AL161734	http://www.ebi.ac.uk/ena/data/view/AL161734
EMBL	AL161734	http://www.ebi.ac.uk/ena/data/view/AL161734
EMBL	AL161734	http://www.ebi.ac.uk/ena/data/view/AL161734
EMBL	AL359270	http://www.ebi.ac.uk/ena/data/view/AL359270
EMBL	AL359270	http://www.ebi.ac.uk/ena/data/view/AL359270
EMBL	AL359270	http://www.ebi.ac.uk/ena/data/view/AL359270
EMBL	AL359270	http://www.ebi.ac.uk/ena/data/view/AL359270
EMBL	AL359270	http://www.ebi.ac.uk/ena/data/view/AL359270
EMBL	AL359270	http://www.ebi.ac.uk/ena/data/view/AL359270
EMBL	AL359270	http://www.ebi.ac.uk/ena/data/view/AL359270
EMBL	AL359270	http://www.ebi.ac.uk/ena/data/view/AL359270
EMBL	AL359270	http://www.ebi.ac.uk/ena/data/view/AL359270
EMBL	AL359270	http://www.ebi.ac.uk/ena/data/view/AL359270
EMBL	AL359270	http://www.ebi.ac.uk/ena/data/view/AL359270
EMBL	AL359270	http://www.ebi.ac.uk/ena/data/view/AL359270
EMBL	AL590998	http://www.ebi.ac.uk/ena/data/view/AL590998
EMBL	AL590998	http://www.ebi.ac.uk/ena/data/view/AL590998
EMBL	AL590998	http://www.ebi.ac.uk/ena/data/view/AL590998
EMBL	AL590998	http://www.ebi.ac.uk/ena/data/view/AL590998
EMBL	AL590998	http://www.ebi.ac.uk/ena/data/view/AL590998
EMBL	AL590998	http://www.ebi.ac.uk/ena/data/view/AL590998
EMBL	AL590998	http://www.ebi.ac.uk/ena/data/view/AL590998
EMBL	AL590998	http://www.ebi.ac.uk/ena/data/view/AL590998
EMBL	AL590998	http://www.ebi.ac.uk/ena/data/view/AL590998
EMBL	AL590998	http://www.ebi.ac.uk/ena/data/view/AL590998
EMBL	AL590998	http://www.ebi.ac.uk/ena/data/view/AL590998
EMBL	AL590998	http://www.ebi.ac.uk/ena/data/view/AL590998
EMBL	L27745	http://www.ebi.ac.uk/ena/data/view/L27745
EMBL	L29384	http://www.ebi.ac.uk/ena/data/view/L29384
EMBL	L29385	http://www.ebi.ac.uk/ena/data/view/L29385
Ensembl	ENST00000358338	http://www.ensembl.org/id/ENST00000358338
Ensembl	ENST00000367567	http://www.ensembl.org/id/ENST00000367567
Ensembl	ENST00000367570	http://www.ensembl.org/id/ENST00000367570
Ensembl	ENST00000367573	http://www.ensembl.org/id/ENST00000367573
Ensembl	ENST00000621551	http://www.ensembl.org/id/ENST00000621551
Ensembl	ENST00000621791	http://www.ensembl.org/id/ENST00000621791
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005891
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0008331	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008331
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0050796	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050796
GO_process	GO:0051899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051899
GO_process	GO:0086010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086010
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	CACNA1E	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CACNA1E
GeneID	777	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=777
GeneTree	ENSGT00830000128247	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00830000128247
HGNC	HGNC:1392	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1392
HOGENOM	HOG000231530	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231530&db=HOGENOM6
HOVERGEN	HBG050763	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050763&db=HOVERGEN
InParanoid	Q15878	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q15878
InterPro	IPR002048	http://www.ebi.ac.uk/interpro/entry/IPR002048
InterPro	IPR002077	http://www.ebi.ac.uk/interpro/entry/IPR002077
InterPro	IPR005449	http://www.ebi.ac.uk/interpro/entry/IPR005449
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR014873	http://www.ebi.ac.uk/interpro/entry/IPR014873
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR031649	http://www.ebi.ac.uk/interpro/entry/IPR031649
Jabion	777	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=777
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:777	http://www.genome.jp/dbget-bin/www_bget?hsa:777
KEGG_Orthology	KO:K04852	http://www.genome.jp/dbget-bin/www_bget?KO:K04852
KEGG_Pathway	ko04010	http://www.genome.jp/kegg-bin/show_pathway?ko04010
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04930	http://www.genome.jp/kegg-bin/show_pathway?ko04930
MIM	601013	http://www.ncbi.nlm.nih.gov/omim/601013
OMA	SVQPSNH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SVQPSNH
OrthoDB	EOG091G0TKO	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0TKO
PANTHER	PTHR10037:SF57	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10037:SF57
PDB	3BXL	http://www.ebi.ac.uk/pdbe-srv/view/entry/3BXL
PDBsum	3BXL	http://www.ebi.ac.uk/pdbsum/3BXL
PRINTS	PR00167	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00167
PRINTS	PR01633	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01633
PROSITE	PS50222	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50222
PSORT	swissprot:CAC1E_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CAC1E_HUMAN
PSORT-B	swissprot:CAC1E_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CAC1E_HUMAN
PSORT2	swissprot:CAC1E_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CAC1E_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF08763	http://pfam.xfam.org/family/PF08763
Pfam	PF16905	http://pfam.xfam.org/family/PF16905
PharmGKB	PA26009	http://www.pharmgkb.org/do/serve?objId=PA26009&objCls=Gene
Phobius	swissprot:CAC1E_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CAC1E_HUMAN
PhylomeDB	Q15878	http://phylomedb.org/?seqid=Q15878
ProteinModelPortal	Q15878	http://www.proteinmodelportal.org/query/uniprot/Q15878
PubMed	15258581	http://www.ncbi.nlm.nih.gov/pubmed/15258581
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	18400181	http://www.ncbi.nlm.nih.gov/pubmed/18400181
PubMed	7536609	http://www.ncbi.nlm.nih.gov/pubmed/7536609
PubMed	8071363	http://www.ncbi.nlm.nih.gov/pubmed/8071363
Reactome	R-HSA-112308	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112308
Reactome	R-HSA-422356	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-422356
RefSeq	NP_000712	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000712
RefSeq	NP_001192222	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001192222
RefSeq	NP_001192223	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001192223
SMART	SM01062	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01062
SMR	Q15878	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q15878
STRING	9606.ENSP00000356545	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000356545&targetmode=cogs
UCSC	uc001gow	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001gow&org=rat
UniGene	Hs.437444	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.437444
UniGene	Hs.611396	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.611396
UniProtKB	CAC1E_HUMAN	http://www.uniprot.org/uniprot/CAC1E_HUMAN
UniProtKB-AC	Q15878	http://www.uniprot.org/uniprot/Q15878
charge	swissprot:CAC1E_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CAC1E_HUMAN
eggNOG	ENOG410INF5	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410INF5
eggNOG	ENOG410YD06	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YD06
epestfind	swissprot:CAC1E_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CAC1E_HUMAN
garnier	swissprot:CAC1E_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CAC1E_HUMAN
helixturnhelix	swissprot:CAC1E_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CAC1E_HUMAN
hmoment	swissprot:CAC1E_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CAC1E_HUMAN
iep	swissprot:CAC1E_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CAC1E_HUMAN
inforesidue	swissprot:CAC1E_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CAC1E_HUMAN
neXtProt	NX_Q15878	http://www.nextprot.org/db/entry/NX_Q15878
octanol	swissprot:CAC1E_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CAC1E_HUMAN
pepcoil	swissprot:CAC1E_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CAC1E_HUMAN
pepdigest	swissprot:CAC1E_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CAC1E_HUMAN
pepinfo	swissprot:CAC1E_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CAC1E_HUMAN
pepnet	swissprot:CAC1E_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CAC1E_HUMAN
pepstats	swissprot:CAC1E_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CAC1E_HUMAN
pepwheel	swissprot:CAC1E_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CAC1E_HUMAN
pepwindow	swissprot:CAC1E_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CAC1E_HUMAN
sigcleave	swissprot:CAC1E_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CAC1E_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S22A1_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=hOCT1G/L554; IsoId=O15245-1; Sequence=Displayed; Name=2; Synonyms=hOCT1G/L506; IsoId=O15245-2; Sequence=VSP_033589, VSP_033590; Name=3; Synonyms=hOCT1G483; IsoId=O15245-3; Sequence=VSP_033588; Name=4; Synonyms=hOCT1G353; IsoId=O15245-4; Sequence=VSP_033587; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 
# AltName	S22A1_HUMAN	Organic cation transporter 1
# BIOPHYSICOCHEMICAL PROPERTIES	S22A1_HUMAN	Kinetic parameters  KM=1.47 mM for metformin {ECO 0000269|PubMed 16272756, ECO 0000269|PubMed 9187257, ECO 0000269|PubMed 9655880}; KM=229 uM for TEA {ECO 0000269|PubMed 16272756, ECO 0000269|PubMed 9187257, ECO 0000269|PubMed 9655880}; KM=14.6 uM for MPP {ECO 0000269|PubMed 16272756, ECO 0000269|PubMed 9187257, ECO 0000269|PubMed 9655880}; Vmax=396 pmol/min/mg enzyme for metformin uptake {ECO 0000269|PubMed 16272756, ECO 0000269|PubMed 9187257, ECO 0000269|PubMed 9655880}; Vmax=2.89 nmol/min/mg enzyme for TEA uptake {ECO 0000269|PubMed 16272756, ECO 0000269|PubMed 9187257, ECO 0000269|PubMed 9655880}; 
# CCDS	CCDS5274	-. [O15245-1]
# CCDS	CCDS5275	-. [O15245-2]
# CDD	cd06174	MFS
# DrugBank	DB00122	Choline
# DrugBank	DB00127	Spermine
# DrugBank	DB00152	Thiamine
# DrugBank	DB00184	Nicotine
# DrugBank	DB00206	Reserpine
# DrugBank	DB00220	Nelfinavir
# DrugBank	DB00224	Indinavir
# DrugBank	DB00242	Cladribine
# DrugBank	DB00280	Disopyramide
# DrugBank	DB00318	Codeine
# DrugBank	DB00331	Metformin
# DrugBank	DB00345	Aminohippurate
# DrugBank	DB00368	Norepinephrine
# DrugBank	DB00396	Progesterone
# DrugBank	DB00406	Gentian Violet
# DrugBank	DB00413	Pramipexole
# DrugBank	DB00457	Prazosin
# DrugBank	DB00458	Imipramine
# DrugBank	DB00468	Quinine
# DrugBank	DB00477	Chlorpromazine
# DrugBank	DB00501	Cimetidine
# DrugBank	DB00520	Caspofungin
# DrugBank	DB00526	Oxaliplatin
# DrugBank	DB00536	Guanidine
# DrugBank	DB00575	Clonidine
# DrugBank	DB00594	Amiloride
# DrugBank	DB00619	Imatinib
# DrugBank	DB00624	Testosterone
# DrugBank	DB00654	Latanoprost
# DrugBank	DB00661	Verapamil
# DrugBank	DB00667	Histamine Phosphate
# DrugBank	DB00668	Epinephrine
# DrugBank	DB00683	Midazolam
# DrugBank	DB00709	Lamivudine
# DrugBank	DB00728	Rocuronium
# DrugBank	DB00783	Estradiol
# DrugBank	DB00787	Aciclovir
# DrugBank	DB00863	Ranitidine
# DrugBank	DB00908	Quinidine
# DrugBank	DB00914	Phenformin
# DrugBank	DB00915	Amantadine
# DrugBank	DB00917	Dinoprostone
# DrugBank	DB00925	Phenoxybenzamine
# DrugBank	DB00987	Cytarabine
# DrugBank	DB00988	Dopamine
# DrugBank	DB01004	Ganciclovir
# DrugBank	DB01032	Probenecid
# DrugBank	DB01035	Procainamide
# DrugBank	DB01075	Diphenhydramine
# DrugBank	DB01114	Chlorphenamine
# DrugBank	DB01151	Desipramine
# DrugBank	DB01193	Acebutolol
# DrugBank	DB01199	Tubocurarine
# DrugBank	DB01232	Saquinavir
# DrugBank	DB01337	Pancuronium
# DrugBank	DB01339	Vecuronium
# DrugBank	DB01614	Acepromazine
# DrugBank	DB01621	Pipotiazine
# DrugBank	DB01622	Thioproperazine
# DrugBank	DB01623	Thiothixene
# DrugBank	DB03128	Acetylcholine
# DrugBank	DB04574	Estropipate
# Ensembl	ENST00000324965	ENSP00000318103; ENSG00000175003. [O15245-2]
# Ensembl	ENST00000366963	ENSP00000355930; ENSG00000175003. [O15245-1]
# Ensembl	ENST00000457470	ENSP00000409557; ENSG00000175003. [O15245-3]
# Ensembl	ENST00000460902	ENSP00000439274; ENSG00000175003. [O15245-4]
# ExpressionAtlas	O15245	baseline and differential
# FUNCTION	S22A1_HUMAN	Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)- N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin- dependent kinase II and LCK tyrosine kinase. {ECO 0000269|PubMed 11388889, ECO 0000269|PubMed 11408531, ECO 0000269|PubMed 15389554, ECO 0000269|PubMed 16272756, ECO 0000269|PubMed 16581093, ECO 0000269|PubMed 9187257, ECO 0000269|PubMed 9260930, ECO 0000269|PubMed 9655880}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:UniProtKB.
# GO_component	GO:0016020	membrane; TAS:UniProtKB.
# GO_component	GO:0016323	basolateral plasma membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0005277	acetylcholine transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0005329	dopamine transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0005333	norepinephrine transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0008513	secondary active organic cation transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015101	organic cation transmembrane transporter activity; TAS:UniProtKB.
# GO_function	GO:0015651	quaternary ammonium group transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0006836	neurotransmitter transport; IBA:GO_Central.
# GO_process	GO:0006855	drug transmembrane transport; TAS:Reactome.
# GO_process	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient; IEA:Ensembl.
# GO_process	GO:0015695	organic cation transport; TAS:UniProtKB.
# GO_process	GO:0015872	dopamine transport; IBA:GO_Central.
# GO_process	GO:0015874	norepinephrine transport; IBA:GO_Central.
# GO_process	GO:0048241	epinephrine transport; IEA:Ensembl.
# GO_process	GO:0051260	protein homooligomerization; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	O15245	HS
# HGNC	HGNC:10963	SLC22A1
# INDUCTION	S22A1_HUMAN	In the liver activated by HNF4A and suppressed by bile acids via NR0B2. Increased by cholesterol treatment in hepatocyte cells. {ECO 0000269|PubMed 16436500, ECO 0000269|PubMed 17635184}. 
# INTERACTION	S22A1_HUMAN	Q96G23 CERS2; NbExp=3; IntAct=EBI-1172714, EBI-1057080; 
# InterPro	IPR004749	Orgcat_transp/SVOP
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR005829	Sugar_transporter_CS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04976	Bile secretion
# MIM	602607	gene
# Organism	S22A1_HUMAN	Homo sapiens (Human)
# PROSITE	PS00216	SUGAR_TRANSPORT_1
# PROSITE	PS50850	MFS
# PTM	S22A1_HUMAN	Phosphorylated. {ECO 0000250}. 
# Pfam	PF00083	Sugar_tr; 2
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-112311	Neurotransmitter Clearance In The Synaptic Cleft
# Reactome	R-HSA-181430	Norepinephrine Neurotransmitter Release Cycle
# Reactome	R-HSA-2161517	Abacavir transmembrane transport
# Reactome	R-HSA-442660	Na+/Cl- dependent neurotransmitter transporters
# Reactome	R-HSA-549127	Organic cation transport
# RecName	S22A1_HUMAN	Solute carrier family 22 member 1
# RefSeq	NP_003048	NM_003057.2. [O15245-1]
# RefSeq	NP_694857	NM_153187.1. [O15245-2]
# RefSeq	XP_006715615	XM_006715552.1. [O15245-3]
# SIMILARITY	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S22A1_HUMAN	Basolateral cell membrane {ECO 0000269|PubMed 16263091}; Multi-pass membrane protein {ECO 0000269|PubMed 16263091}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.19.29	the major facilitator superfamily (mfs)
# TIGRFAMs	TIGR00898	2A0119
# TISSUE SPECIFICITY	S22A1_HUMAN	Widely expressed with high level in liver. Isoform 1 and isoform 2 are expressed in liver. Isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in glial cell lines. {ECO 0000269|PubMed 11388889, ECO 0000269|PubMed 9187257, ECO 0000269|PubMed 9260930}. 
# UCSC	uc003qtc	human. [O15245-1]
# eggNOG	COG0477	LUCA
# eggNOG	KOG0255	Eukaryota
BLAST	swissprot:S22A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S22A1_HUMAN
COXPRESdb	6580	http://coxpresdb.jp/data/gene/6580.shtml
CleanEx	HS_SLC22A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC22A1
DOI	10.1002/jcp.20081	http://dx.doi.org/10.1002/jcp.20081
DOI	10.1016/j.bbrc.2003.11.175	http://dx.doi.org/10.1016/j.bbrc.2003.11.175
DOI	10.1016/j.bcp.2005.09.011	http://dx.doi.org/10.1016/j.bcp.2005.09.011
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.neuropharm.2006.01.005	http://dx.doi.org/10.1016/j.neuropharm.2006.01.005
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1046/j.1469-1809.2000.6430267.x	http://dx.doi.org/10.1046/j.1469-1809.2000.6430267.x
DOI	10.1073/pnas.0730858100	http://dx.doi.org/10.1073/pnas.0730858100
DOI	10.1089/dna.1997.16.871	http://dx.doi.org/10.1089/dna.1997.16.871
DOI	10.1097/00008571-200211000-00002	http://dx.doi.org/10.1097/00008571-200211000-00002
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1472-8206.2007.00517.x	http://dx.doi.org/10.1111/j.1472-8206.2007.00517.x
DOI	10.1124/jpet.105.099929	http://dx.doi.org/10.1124/jpet.105.099929
DOI	10.2133/dmpk.19.308	http://dx.doi.org/10.2133/dmpk.19.308
DOI	10.2133/dmpk.20.379	http://dx.doi.org/10.2133/dmpk.20.379
DrugBank	DB00122	http://www.drugbank.ca/drugs/DB00122
DrugBank	DB00127	http://www.drugbank.ca/drugs/DB00127
DrugBank	DB00152	http://www.drugbank.ca/drugs/DB00152
DrugBank	DB00184	http://www.drugbank.ca/drugs/DB00184
DrugBank	DB00206	http://www.drugbank.ca/drugs/DB00206
DrugBank	DB00220	http://www.drugbank.ca/drugs/DB00220
DrugBank	DB00224	http://www.drugbank.ca/drugs/DB00224
DrugBank	DB00242	http://www.drugbank.ca/drugs/DB00242
DrugBank	DB00280	http://www.drugbank.ca/drugs/DB00280
DrugBank	DB00318	http://www.drugbank.ca/drugs/DB00318
DrugBank	DB00331	http://www.drugbank.ca/drugs/DB00331
DrugBank	DB00345	http://www.drugbank.ca/drugs/DB00345
DrugBank	DB00368	http://www.drugbank.ca/drugs/DB00368
DrugBank	DB00396	http://www.drugbank.ca/drugs/DB00396
DrugBank	DB00406	http://www.drugbank.ca/drugs/DB00406
DrugBank	DB00413	http://www.drugbank.ca/drugs/DB00413
DrugBank	DB00457	http://www.drugbank.ca/drugs/DB00457
DrugBank	DB00458	http://www.drugbank.ca/drugs/DB00458
DrugBank	DB00468	http://www.drugbank.ca/drugs/DB00468
DrugBank	DB00477	http://www.drugbank.ca/drugs/DB00477
DrugBank	DB00501	http://www.drugbank.ca/drugs/DB00501
DrugBank	DB00520	http://www.drugbank.ca/drugs/DB00520
DrugBank	DB00526	http://www.drugbank.ca/drugs/DB00526
DrugBank	DB00536	http://www.drugbank.ca/drugs/DB00536
DrugBank	DB00575	http://www.drugbank.ca/drugs/DB00575
DrugBank	DB00594	http://www.drugbank.ca/drugs/DB00594
DrugBank	DB00619	http://www.drugbank.ca/drugs/DB00619
DrugBank	DB00624	http://www.drugbank.ca/drugs/DB00624
DrugBank	DB00654	http://www.drugbank.ca/drugs/DB00654
DrugBank	DB00661	http://www.drugbank.ca/drugs/DB00661
DrugBank	DB00667	http://www.drugbank.ca/drugs/DB00667
DrugBank	DB00668	http://www.drugbank.ca/drugs/DB00668
DrugBank	DB00683	http://www.drugbank.ca/drugs/DB00683
DrugBank	DB00709	http://www.drugbank.ca/drugs/DB00709
DrugBank	DB00728	http://www.drugbank.ca/drugs/DB00728
DrugBank	DB00783	http://www.drugbank.ca/drugs/DB00783
DrugBank	DB00787	http://www.drugbank.ca/drugs/DB00787
DrugBank	DB00863	http://www.drugbank.ca/drugs/DB00863
DrugBank	DB00908	http://www.drugbank.ca/drugs/DB00908
DrugBank	DB00914	http://www.drugbank.ca/drugs/DB00914
DrugBank	DB00915	http://www.drugbank.ca/drugs/DB00915
DrugBank	DB00917	http://www.drugbank.ca/drugs/DB00917
DrugBank	DB00925	http://www.drugbank.ca/drugs/DB00925
DrugBank	DB00987	http://www.drugbank.ca/drugs/DB00987
DrugBank	DB00988	http://www.drugbank.ca/drugs/DB00988
DrugBank	DB01004	http://www.drugbank.ca/drugs/DB01004
DrugBank	DB01032	http://www.drugbank.ca/drugs/DB01032
DrugBank	DB01035	http://www.drugbank.ca/drugs/DB01035
DrugBank	DB01075	http://www.drugbank.ca/drugs/DB01075
DrugBank	DB01114	http://www.drugbank.ca/drugs/DB01114
DrugBank	DB01151	http://www.drugbank.ca/drugs/DB01151
DrugBank	DB01193	http://www.drugbank.ca/drugs/DB01193
DrugBank	DB01199	http://www.drugbank.ca/drugs/DB01199
DrugBank	DB01232	http://www.drugbank.ca/drugs/DB01232
DrugBank	DB01337	http://www.drugbank.ca/drugs/DB01337
DrugBank	DB01339	http://www.drugbank.ca/drugs/DB01339
DrugBank	DB01614	http://www.drugbank.ca/drugs/DB01614
DrugBank	DB01621	http://www.drugbank.ca/drugs/DB01621
DrugBank	DB01622	http://www.drugbank.ca/drugs/DB01622
DrugBank	DB01623	http://www.drugbank.ca/drugs/DB01623
DrugBank	DB03128	http://www.drugbank.ca/drugs/DB03128
DrugBank	DB04574	http://www.drugbank.ca/drugs/DB04574
EMBL	AJ243995	http://www.ebi.ac.uk/ena/data/view/AJ243995
EMBL	AJ243996	http://www.ebi.ac.uk/ena/data/view/AJ243996
EMBL	AJ243998	http://www.ebi.ac.uk/ena/data/view/AJ243998
EMBL	AJ243999	http://www.ebi.ac.uk/ena/data/view/AJ243999
EMBL	AJ244000	http://www.ebi.ac.uk/ena/data/view/AJ244000
EMBL	AJ245460	http://www.ebi.ac.uk/ena/data/view/AJ245460
EMBL	AJ276051	http://www.ebi.ac.uk/ena/data/view/AJ276051
EMBL	AJ276052	http://www.ebi.ac.uk/ena/data/view/AJ276052
EMBL	AJ276053	http://www.ebi.ac.uk/ena/data/view/AJ276053
EMBL	AK289887	http://www.ebi.ac.uk/ena/data/view/AK289887
EMBL	AL353625	http://www.ebi.ac.uk/ena/data/view/AL353625
EMBL	BC126364	http://www.ebi.ac.uk/ena/data/view/BC126364
EMBL	U77086	http://www.ebi.ac.uk/ena/data/view/U77086
EMBL	X98332	http://www.ebi.ac.uk/ena/data/view/X98332
Ensembl	ENST00000324965	http://www.ensembl.org/id/ENST00000324965
Ensembl	ENST00000366963	http://www.ensembl.org/id/ENST00000366963
Ensembl	ENST00000457470	http://www.ensembl.org/id/ENST00000457470
Ensembl	ENST00000460902	http://www.ensembl.org/id/ENST00000460902
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_function	GO:0005277	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005277
GO_function	GO:0005329	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005329
GO_function	GO:0005333	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005333
GO_function	GO:0008513	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008513
GO_function	GO:0015101	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015101
GO_function	GO:0015651	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015651
GO_process	GO:0006836	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006836
GO_process	GO:0006855	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006855
GO_process	GO:0010248	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010248
GO_process	GO:0015695	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015695
GO_process	GO:0015872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015872
GO_process	GO:0015874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015874
GO_process	GO:0048241	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048241
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC22A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC22A1
GeneID	6580	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6580
GeneTree	ENSGT00760000118852	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118852
HGNC	HGNC:10963	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10963
HOGENOM	HOG000234568	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234568&db=HOGENOM6
HOVERGEN	HBG061545	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG061545&db=HOVERGEN
HPA	HPA029846	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA029846
InParanoid	O15245	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O15245
IntAct	O15245	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O15245*
InterPro	IPR004749	http://www.ebi.ac.uk/interpro/entry/IPR004749
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR005829	http://www.ebi.ac.uk/interpro/entry/IPR005829
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	6580	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6580
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6580	http://www.genome.jp/dbget-bin/www_bget?hsa:6580
KEGG_Orthology	KO:K08198	http://www.genome.jp/dbget-bin/www_bget?KO:K08198
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
MIM	602607	http://www.ncbi.nlm.nih.gov/omim/602607
OMA	DLFQSCL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DLFQSCL
OrthoDB	EOG091G05AC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05AC
PROSITE	PS00216	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00216
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:S22A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S22A1_HUMAN
PSORT-B	swissprot:S22A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S22A1_HUMAN
PSORT2	swissprot:S22A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S22A1_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
PharmGKB	PA329	http://www.pharmgkb.org/do/serve?objId=PA329&objCls=Gene
Phobius	swissprot:S22A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S22A1_HUMAN
PhylomeDB	O15245	http://phylomedb.org/?seqid=O15245
ProteinModelPortal	O15245	http://www.proteinmodelportal.org/query/uniprot/O15245
PubMed	11388889	http://www.ncbi.nlm.nih.gov/pubmed/11388889
PubMed	11408531	http://www.ncbi.nlm.nih.gov/pubmed/11408531
PubMed	12439218	http://www.ncbi.nlm.nih.gov/pubmed/12439218
PubMed	12719534	http://www.ncbi.nlm.nih.gov/pubmed/12719534
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14697261	http://www.ncbi.nlm.nih.gov/pubmed/14697261
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15389554	http://www.ncbi.nlm.nih.gov/pubmed/15389554
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15499200	http://www.ncbi.nlm.nih.gov/pubmed/15499200
PubMed	16263091	http://www.ncbi.nlm.nih.gov/pubmed/16263091
PubMed	16272756	http://www.ncbi.nlm.nih.gov/pubmed/16272756
PubMed	16436500	http://www.ncbi.nlm.nih.gov/pubmed/16436500
PubMed	16581093	http://www.ncbi.nlm.nih.gov/pubmed/16581093
PubMed	17635184	http://www.ncbi.nlm.nih.gov/pubmed/17635184
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	9187257	http://www.ncbi.nlm.nih.gov/pubmed/9187257
PubMed	9260930	http://www.ncbi.nlm.nih.gov/pubmed/9260930
PubMed	9655880	http://www.ncbi.nlm.nih.gov/pubmed/9655880
Reactome	R-HSA-112311	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112311
Reactome	R-HSA-181430	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-181430
Reactome	R-HSA-2161517	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2161517
Reactome	R-HSA-442660	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442660
Reactome	R-HSA-549127	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-549127
RefSeq	NP_003048	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003048
RefSeq	NP_694857	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_694857
RefSeq	XP_006715615	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006715615
STRING	9606.ENSP00000355930	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000355930&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.19.29	http://www.tcdb.org/search/result.php?tc=2.A.1.19.29
TIGRFAMs	TIGR00898	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00898
UCSC	uc003qtc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003qtc&org=rat
UniGene	Hs.117367	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.117367
UniProtKB	S22A1_HUMAN	http://www.uniprot.org/uniprot/S22A1_HUMAN
UniProtKB-AC	O15245	http://www.uniprot.org/uniprot/O15245
charge	swissprot:S22A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S22A1_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG0255	http://eggnogapi.embl.de/nog_data/html/tree/KOG0255
epestfind	swissprot:S22A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S22A1_HUMAN
garnier	swissprot:S22A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S22A1_HUMAN
helixturnhelix	swissprot:S22A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S22A1_HUMAN
hmoment	swissprot:S22A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S22A1_HUMAN
iep	swissprot:S22A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S22A1_HUMAN
inforesidue	swissprot:S22A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S22A1_HUMAN
neXtProt	NX_O15245	http://www.nextprot.org/db/entry/NX_O15245
octanol	swissprot:S22A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S22A1_HUMAN
pepcoil	swissprot:S22A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S22A1_HUMAN
pepdigest	swissprot:S22A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S22A1_HUMAN
pepinfo	swissprot:S22A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S22A1_HUMAN
pepnet	swissprot:S22A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S22A1_HUMAN
pepstats	swissprot:S22A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S22A1_HUMAN
pepwheel	swissprot:S22A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S22A1_HUMAN
pepwindow	swissprot:S22A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S22A1_HUMAN
sigcleave	swissprot:S22A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S22A1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ABCC9_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=SUR2A; IsoId=O60706-1; Sequence=Displayed; Name=SUR2B; IsoId=O60706-2; Sequence=VSP_000058; 
# AltName	ABCC9_HUMAN	Sulfonylurea receptor 2
# BioGrid	115371	3
# CCDS	CCDS8693	-. [O60706-2]
# CCDS	CCDS8694	-. [O60706-1]
# DISEASE	ABCC9_HUMAN	Atrial fibrillation, familial, 12 (ATFB12) [MIM 614050]  A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. {ECO 0000269|PubMed 17245405}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ABCC9_HUMAN	Cardiomyopathy, dilated 1O (CMD1O) [MIM 608569]  A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. {ECO 0000269|PubMed 15034580}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ABCC9_HUMAN	Hypertrichotic osteochondrodysplasia (HTOCD) [MIM 239850]  A rare disorder characterized by congenital hypertrichosis, neonatal macrosomia, a distinct osteochondrodysplasia, and cardiomegaly. The hypertrichosis leads to thick scalp hair, which extends onto the forehead, and a general increase in body hair. In addition, macrocephaly and coarse facial features, including a broad nasal bridge, epicanthal folds, a wide mouth, and full lips, can be suggestive of a storage disorder. About half of affected individuals are macrosomic and edematous at birth, whereas in childhood they usually have a muscular appearance with little subcutaneous fat. Thickened calvarium, narrow thorax, wide ribs, flattened or ovoid vertebral bodies, coxa valga, osteopenia, enlarged medullary canals, and metaphyseal widening of long bones have been reported. Cardiac manifestations such as patent ductus arteriosus, ventricular hypertrophy, pulmonary hypertension, and pericardial effusions are present in approximately 80% of cases. Motor development is usually delayed due to hypotonia. Most patients have a mild speech delay, and a small percentage have learning difficulties or intellectual disability. {ECO 0000269|PubMed 22608503, ECO 0000269|PubMed 22610116, ECO 0000269|PubMed 26621776}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00171	Adenosine triphosphate
# DrugBank	DB01016	Glyburide
# Ensembl	ENST00000261200	ENSP00000261200; ENSG00000069431. [O60706-2]
# Ensembl	ENST00000261201	ENSP00000261201; ENSG00000069431. [O60706-1]
# ExpressionAtlas	O60706	baseline and differential
# FUNCTION	ABCC9_HUMAN	Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. {ECO 0000269|PubMed 9831708}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IDA:BHF-UCL.
# GO_component	GO:0008282	ATP-sensitive potassium channel complex; ISS:BHF-UCL.
# GO_component	GO:0030017	sarcomere; IEA:Ensembl.
# GO_component	GO:0042383	sarcolemma; IEA:Ensembl.
# GO_function	GO:0005215	transporter activity; TAS:ProtInc.
# GO_function	GO:0005267	potassium channel activity; IEA:Ensembl.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0008281	sulfonylurea receptor activity; ISS:BHF-UCL.
# GO_function	GO:0015459	potassium channel regulator activity; ISS:BHF-UCL.
# GO_function	GO:0043225	ATPase-coupled anion transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0044325	ion channel binding; IPI:BHF-UCL.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0010107	potassium ion import; ISS:BHF-UCL.
# GO_process	GO:0051607	defense response to virus; IMP:MGI.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 2.
# Genevisible	O60706	HS
# HGNC	HGNC:60	ABCC9
# InterPro	IPR000388	Sulphorea_rcpt
# InterPro	IPR001475	ABCC9
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR011527	ABC1_TM_dom
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00294	[Cardiovascular disease] Dilated cardiomyopathy (DCM)
# KEGG_Disease	H00731	[Cardiovascular disease] Atrial fibrillation
# KEGG_Pathway	ko02010	ABC transporters
# MIM	239850	phenotype
# MIM	601439	gene
# MIM	608569	phenotype
# MIM	614050	phenotype
# MISCELLANEOUS	May contribute to the regulation of sleep duration. An intronic variant of this gene may account for about 5% of the variation of sleep duration between individuals (PubMed:22105623). Sleep duration is influenced both by environmental and genetic factors, with an estimated heritability of about 40%. Numerous genes are expected to contribute to the regulation of sleep duration. {ECO	0000305|PubMed:22105623}. 
# Organism	ABCC9_HUMAN	Homo sapiens (Human)
# Orphanet	1517	Hypertrichotic osteochondrodysplasia, Cantu type
# Orphanet	154	Familial isolated dilated cardiomyopathy
# Orphanet	334	Familial atrial fibrillation
# Orphanet	965	Acromegaloid facial appearance syndrome
# Orphanet	966	Hypertrichosis-acromegaloid facial appearance syndrome
# PANTHER	PTHR24223:SF173	PTHR24223:SF173; 4
# PRINTS	PR01092	SULFNYLUREAR
# PRINTS	PR01094	SULFNYLUR2
# PROSITE	PS00211	ABC_TRANSPORTER_1; 2
# PROSITE	PS50893	ABC_TRANSPORTER_2; 2
# PROSITE	PS50929	ABC_TM1F; 2
# Pfam	PF00005	ABC_tran; 2
# Pfam	PF00664	ABC_membrane; 2
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-1296025	ATP sensitive Potassium channels
# Reactome	R-HSA-382556	ABC-family proteins mediated transport
# Reactome	R-HSA-5578775	Ion homeostasis
# RecName	ABCC9_HUMAN	ATP-binding cassette sub-family C member 9
# RefSeq	NP_005682	NM_005691.3. [O60706-1]
# RefSeq	NP_064693	NM_020297.3. [O60706-2]
# RefSeq	XP_005253341	XM_005253284.3. [O60706-2]
# RefSeq	XP_005253343	XM_005253286.3. [O60706-2]
# RefSeq	XP_005253344	XM_005253287.4. [O60706-1]
# RefSeq	XP_005253345	XM_005253288.3. [O60706-2]
# RefSeq	XP_011518847	XM_011520545.2. [O60706-2]
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 2 ABC transmembrane type-1 domains. {ECO:0000255|PROSITE-ProRule	PRU00441}. 
# SIMILARITY	Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA; 2
# SUBCELLULAR LOCATION	ABCC9_HUMAN	Membrane {ECO 0000255|PROSITE- ProRule PRU00441}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00441}. 
# SUBUNIT	Interacts with KCNJ11. {ECO:0000269|PubMed	9831708}. 
# SUPFAM	SSF52540	SSF52540; 2
# SUPFAM	SSF90123	SSF90123; 2
# TCDB	3.A.1.208.23	the atp-binding cassette (abc) superfamily
# UCSC	uc001rfh	human. [O60706-1]
# WEB RESOURCE	ABCC9_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=O60706";
# WEB RESOURCE	ABCC9_HUMAN	Name=Protein Spotlight; Note=On The Other Side - Issue 139 of June 2012; URL="http //web.expasy.org/spotlight/back_issues/139"; 
# eggNOG	COG1132	LUCA
# eggNOG	KOG0054	Eukaryota
BLAST	swissprot:ABCC9_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCC9_HUMAN
BioCyc	ZFISH:ENSG00000069431-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000069431-MONOMER
COXPRESdb	10060	http://coxpresdb.jp/data/gene/10060.shtml
CleanEx	HS_ABCC9	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCC9
DOI	10.1016/j.ajhg.2012.04.014	http://dx.doi.org/10.1016/j.ajhg.2012.04.014
DOI	10.1038/mp.2011.142	http://dx.doi.org/10.1038/mp.2011.142
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1038/ncpcardio0792	http://dx.doi.org/10.1038/ncpcardio0792
DOI	10.1038/ng.2324	http://dx.doi.org/10.1038/ng.2324
DOI	10.1038/ng1329	http://dx.doi.org/10.1038/ng1329
DOI	10.1085/jgp.201511495	http://dx.doi.org/10.1085/jgp.201511495
DOI	10.1161/01.RES.83.11.1132	http://dx.doi.org/10.1161/01.RES.83.11.1132
DrugBank	DB00171	http://www.drugbank.ca/drugs/DB00171
DrugBank	DB01016	http://www.drugbank.ca/drugs/DB01016
EMBL	AC008250	http://www.ebi.ac.uk/ena/data/view/AC008250
EMBL	AC084806	http://www.ebi.ac.uk/ena/data/view/AC084806
EMBL	AF061289	http://www.ebi.ac.uk/ena/data/view/AF061289
EMBL	AF061289	http://www.ebi.ac.uk/ena/data/view/AF061289
EMBL	AF061290	http://www.ebi.ac.uk/ena/data/view/AF061290
EMBL	AF061290	http://www.ebi.ac.uk/ena/data/view/AF061290
EMBL	AF061291	http://www.ebi.ac.uk/ena/data/view/AF061291
EMBL	AF061291	http://www.ebi.ac.uk/ena/data/view/AF061291
EMBL	AF061292	http://www.ebi.ac.uk/ena/data/view/AF061292
EMBL	AF061292	http://www.ebi.ac.uk/ena/data/view/AF061292
EMBL	AF061293	http://www.ebi.ac.uk/ena/data/view/AF061293
EMBL	AF061293	http://www.ebi.ac.uk/ena/data/view/AF061293
EMBL	AF061294	http://www.ebi.ac.uk/ena/data/view/AF061294
EMBL	AF061294	http://www.ebi.ac.uk/ena/data/view/AF061294
EMBL	AF061295	http://www.ebi.ac.uk/ena/data/view/AF061295
EMBL	AF061295	http://www.ebi.ac.uk/ena/data/view/AF061295
EMBL	AF061296	http://www.ebi.ac.uk/ena/data/view/AF061296
EMBL	AF061296	http://www.ebi.ac.uk/ena/data/view/AF061296
EMBL	AF061297	http://www.ebi.ac.uk/ena/data/view/AF061297
EMBL	AF061297	http://www.ebi.ac.uk/ena/data/view/AF061297
EMBL	AF061298	http://www.ebi.ac.uk/ena/data/view/AF061298
EMBL	AF061298	http://www.ebi.ac.uk/ena/data/view/AF061298
EMBL	AF061299	http://www.ebi.ac.uk/ena/data/view/AF061299
EMBL	AF061299	http://www.ebi.ac.uk/ena/data/view/AF061299
EMBL	AF061300	http://www.ebi.ac.uk/ena/data/view/AF061300
EMBL	AF061300	http://www.ebi.ac.uk/ena/data/view/AF061300
EMBL	AF061301	http://www.ebi.ac.uk/ena/data/view/AF061301
EMBL	AF061301	http://www.ebi.ac.uk/ena/data/view/AF061301
EMBL	AF061302	http://www.ebi.ac.uk/ena/data/view/AF061302
EMBL	AF061302	http://www.ebi.ac.uk/ena/data/view/AF061302
EMBL	AF061303	http://www.ebi.ac.uk/ena/data/view/AF061303
EMBL	AF061303	http://www.ebi.ac.uk/ena/data/view/AF061303
EMBL	AF061304	http://www.ebi.ac.uk/ena/data/view/AF061304
EMBL	AF061304	http://www.ebi.ac.uk/ena/data/view/AF061304
EMBL	AF061305	http://www.ebi.ac.uk/ena/data/view/AF061305
EMBL	AF061305	http://www.ebi.ac.uk/ena/data/view/AF061305
EMBL	AF061306	http://www.ebi.ac.uk/ena/data/view/AF061306
EMBL	AF061306	http://www.ebi.ac.uk/ena/data/view/AF061306
EMBL	AF061307	http://www.ebi.ac.uk/ena/data/view/AF061307
EMBL	AF061307	http://www.ebi.ac.uk/ena/data/view/AF061307
EMBL	AF061308	http://www.ebi.ac.uk/ena/data/view/AF061308
EMBL	AF061308	http://www.ebi.ac.uk/ena/data/view/AF061308
EMBL	AF061309	http://www.ebi.ac.uk/ena/data/view/AF061309
EMBL	AF061309	http://www.ebi.ac.uk/ena/data/view/AF061309
EMBL	AF061310	http://www.ebi.ac.uk/ena/data/view/AF061310
EMBL	AF061310	http://www.ebi.ac.uk/ena/data/view/AF061310
EMBL	AF061311	http://www.ebi.ac.uk/ena/data/view/AF061311
EMBL	AF061311	http://www.ebi.ac.uk/ena/data/view/AF061311
EMBL	AF061312	http://www.ebi.ac.uk/ena/data/view/AF061312
EMBL	AF061312	http://www.ebi.ac.uk/ena/data/view/AF061312
EMBL	AF061313	http://www.ebi.ac.uk/ena/data/view/AF061313
EMBL	AF061313	http://www.ebi.ac.uk/ena/data/view/AF061313
EMBL	AF061314	http://www.ebi.ac.uk/ena/data/view/AF061314
EMBL	AF061314	http://www.ebi.ac.uk/ena/data/view/AF061314
EMBL	AF061315	http://www.ebi.ac.uk/ena/data/view/AF061315
EMBL	AF061315	http://www.ebi.ac.uk/ena/data/view/AF061315
EMBL	AF061316	http://www.ebi.ac.uk/ena/data/view/AF061316
EMBL	AF061316	http://www.ebi.ac.uk/ena/data/view/AF061316
EMBL	AF061317	http://www.ebi.ac.uk/ena/data/view/AF061317
EMBL	AF061317	http://www.ebi.ac.uk/ena/data/view/AF061317
EMBL	AF061318	http://www.ebi.ac.uk/ena/data/view/AF061318
EMBL	AF061318	http://www.ebi.ac.uk/ena/data/view/AF061318
EMBL	AF061319	http://www.ebi.ac.uk/ena/data/view/AF061319
EMBL	AF061319	http://www.ebi.ac.uk/ena/data/view/AF061319
EMBL	AF061320	http://www.ebi.ac.uk/ena/data/view/AF061320
EMBL	AF061320	http://www.ebi.ac.uk/ena/data/view/AF061320
EMBL	AF061321	http://www.ebi.ac.uk/ena/data/view/AF061321
EMBL	AF061321	http://www.ebi.ac.uk/ena/data/view/AF061321
EMBL	AF061322	http://www.ebi.ac.uk/ena/data/view/AF061322
EMBL	AF061322	http://www.ebi.ac.uk/ena/data/view/AF061322
EMBL	AF061323	http://www.ebi.ac.uk/ena/data/view/AF061323
EMBL	AF061324	http://www.ebi.ac.uk/ena/data/view/AF061324
Ensembl	ENST00000261200	http://www.ensembl.org/id/ENST00000261200
Ensembl	ENST00000261201	http://www.ensembl.org/id/ENST00000261201
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0008282	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008282
GO_component	GO:0030017	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030017
GO_component	GO:0042383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042383
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0008281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008281
GO_function	GO:0015459	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015459
GO_function	GO:0043225	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043225
GO_function	GO:0044325	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044325
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0010107	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010107
GO_process	GO:0051607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051607
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCC9	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCC9
GeneID	10060	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10060
GeneTree	ENSGT00860000133722	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00860000133722
HGNC	HGNC:60	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:60
HOVERGEN	HBG101342	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG101342&db=HOVERGEN
HPA	HPA007279	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA007279
InParanoid	O60706	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O60706
IntAct	O60706	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O60706*
InterPro	IPR000388	http://www.ebi.ac.uk/interpro/entry/IPR000388
InterPro	IPR001475	http://www.ebi.ac.uk/interpro/entry/IPR001475
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR011527	http://www.ebi.ac.uk/interpro/entry/IPR011527
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	10060	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10060
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00294	http://www.genome.jp/dbget-bin/www_bget?H00294
KEGG_Disease	H00731	http://www.genome.jp/dbget-bin/www_bget?H00731
KEGG_Gene	hsa:10060	http://www.genome.jp/dbget-bin/www_bget?hsa:10060
KEGG_Orthology	KO:K05033	http://www.genome.jp/dbget-bin/www_bget?KO:K05033
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
MIM	239850	http://www.ncbi.nlm.nih.gov/omim/239850
MIM	601439	http://www.ncbi.nlm.nih.gov/omim/601439
MIM	608569	http://www.ncbi.nlm.nih.gov/omim/608569
MIM	614050	http://www.ncbi.nlm.nih.gov/omim/614050
OMA	HAYASGN	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HAYASGN
Orphanet	1517	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1517
Orphanet	154	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=154
Orphanet	334	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=334
Orphanet	965	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=965
Orphanet	966	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=966
OrthoDB	EOG091G00IN	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00IN
PANTHER	PTHR24223:SF173	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24223:SF173
PRINTS	PR01092	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01092
PRINTS	PR01094	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01094
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PROSITE	PS50929	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929
PSORT	swissprot:ABCC9_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCC9_HUMAN
PSORT-B	swissprot:ABCC9_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCC9_HUMAN
PSORT2	swissprot:ABCC9_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCC9_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF00664	http://pfam.xfam.org/family/PF00664
PharmGKB	PA396	http://www.pharmgkb.org/do/serve?objId=PA396&objCls=Gene
Phobius	swissprot:ABCC9_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCC9_HUMAN
PhylomeDB	O60706	http://phylomedb.org/?seqid=O60706
ProteinModelPortal	O60706	http://www.proteinmodelportal.org/query/uniprot/O60706
PubMed	15034580	http://www.ncbi.nlm.nih.gov/pubmed/15034580
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	17245405	http://www.ncbi.nlm.nih.gov/pubmed/17245405
PubMed	22105623	http://www.ncbi.nlm.nih.gov/pubmed/22105623
PubMed	22608503	http://www.ncbi.nlm.nih.gov/pubmed/22608503
PubMed	22610116	http://www.ncbi.nlm.nih.gov/pubmed/22610116
PubMed	26621776	http://www.ncbi.nlm.nih.gov/pubmed/26621776
PubMed	9457174	http://www.ncbi.nlm.nih.gov/pubmed/9457174
PubMed	9831708	http://www.ncbi.nlm.nih.gov/pubmed/9831708
Reactome	R-HSA-1296025	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296025
Reactome	R-HSA-382556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-382556
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
RefSeq	NP_005682	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_005682
RefSeq	NP_064693	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_064693
RefSeq	XP_005253341	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005253341
RefSeq	XP_005253343	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005253343
RefSeq	XP_005253344	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005253344
RefSeq	XP_005253345	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005253345
RefSeq	XP_011518847	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011518847
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
STRING	9606.ENSP00000261200	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000261200&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
SUPFAM	SSF90123	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123
TCDB	3.A.1.208.23	http://www.tcdb.org/search/result.php?tc=3.A.1.208.23
UCSC	uc001rfh	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001rfh&org=rat
UniGene	Hs.732701	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.732701
UniProtKB	ABCC9_HUMAN	http://www.uniprot.org/uniprot/ABCC9_HUMAN
UniProtKB-AC	O60706	http://www.uniprot.org/uniprot/O60706
charge	swissprot:ABCC9_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCC9_HUMAN
eggNOG	COG1132	http://eggnogapi.embl.de/nog_data/html/tree/COG1132
eggNOG	KOG0054	http://eggnogapi.embl.de/nog_data/html/tree/KOG0054
epestfind	swissprot:ABCC9_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCC9_HUMAN
garnier	swissprot:ABCC9_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCC9_HUMAN
helixturnhelix	swissprot:ABCC9_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCC9_HUMAN
hmoment	swissprot:ABCC9_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCC9_HUMAN
iep	swissprot:ABCC9_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCC9_HUMAN
inforesidue	swissprot:ABCC9_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCC9_HUMAN
neXtProt	NX_O60706	http://www.nextprot.org/db/entry/NX_O60706
octanol	swissprot:ABCC9_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCC9_HUMAN
pepcoil	swissprot:ABCC9_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCC9_HUMAN
pepdigest	swissprot:ABCC9_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCC9_HUMAN
pepinfo	swissprot:ABCC9_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCC9_HUMAN
pepnet	swissprot:ABCC9_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCC9_HUMAN
pepstats	swissprot:ABCC9_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCC9_HUMAN
pepwheel	swissprot:ABCC9_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCC9_HUMAN
pepwindow	swissprot:ABCC9_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCC9_HUMAN
sigcleave	swissprot:ABCC9_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCC9_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S39A4_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P5W5-1; Sequence=Displayed; Name=2; IsoId=Q6P5W5-2; Sequence=VSP_015911, VSP_015912; 
# AltName	S39A4_HUMAN	Solute carrier family 39 member 4
# AltName	S39A4_HUMAN	Zrt- and Irt-like protein 4
# BioGrid	120769	101
# CCDS	CCDS43782	-. [Q6P5W5-2]
# CCDS	CCDS6424	-. [Q6P5W5-1]
# DISEASE	S39A4_HUMAN	Acrodermatitis enteropathica, zinc-deficiency type (AEZ) [MIM 201100]  A rare autosomal recessive disease caused by the inability to absorb sufficient zinc. The clinical features are growth retardation, immune-system dysfunction, alopecia, severe dermatitis, diarrhea and occasionally mental disorders. {ECO 0000269|PubMed 12032886, ECO 0000269|PubMed 12068297, ECO 0000269|PubMed 12787121, ECO 0000269|PubMed 14702039}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000301305	ENSP00000301305; ENSG00000147804
# ExpressionAtlas	Q6P5W5	baseline and differential
# FUNCTION	S39A4_HUMAN	Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability (By similarity). {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0016023	cytoplasmic, membrane-bounded vesicle; IDA:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IEA:Ensembl.
# GO_component	GO:0055038	recycling endosome membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005385	zinc ion transmembrane transporter activity; IDA:CACAO.
# GO_process	GO:0006882	cellular zinc ion homeostasis; IBA:GO_Central.
# GO_process	GO:0034224	cellular response to zinc ion starvation; IEA:Ensembl.
# GO_process	GO:0071578	zinc II ion transmembrane import; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q6P5W5	HS
# HGNC	HGNC:17129	SLC39A4
# InterPro	IPR003689	ZIP
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Disease	H00212	[Inherited metabolic disease; Skin and connective tissue disease; Gastrointestinal disease] Acrodermatitis enteropathica (AEZ)
# KEGG_Pathway	ko04978	Mineral absorption
# MIM	201100	phenotype
# MIM	607059	gene
# Organism	S39A4_HUMAN	Homo sapiens (Human)
# Orphanet	37	Acrodermatitis enteropathica
# Pfam	PF02535	Zip
# Proteomes	UP000005640	Chromosome 8
# Reactome	R-HSA-442380	Zinc influx into cells by the SLC39 gene family
# RecName	S39A4_HUMAN	Zinc transporter ZIP4
# RefSeq	NP_060237	NM_017767.2. [Q6P5W5-2]
# RefSeq	NP_570901	NM_130849.3. [Q6P5W5-1]
# SEQUENCE CAUTION	Sequence=BAA91091.1; Type=Frameshift; Positions=573, 598, 618; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the ZIP transporter (TC 2.A.5) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S39A4_HUMAN	Cell membrane {ECO 0000269|PubMed 14612438}; Multi-pass membrane protein {ECO 0000269|PubMed 14612438}. Recycling endosome membrane {ECO 0000269|PubMed 14612438}; Multi- pass membrane protein {ECO 0000269|PubMed 14612438}. Note=Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma membrane in response to zinc availability. 
# TCDB	2.A.5.4	the zinc (zn(2+))-iron (fe(2+)) permease (zip) family
# TISSUE SPECIFICITY	S39A4_HUMAN	Highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum. {ECO 0000269|PubMed 12032886, ECO 0000269|PubMed 12068297}. 
# UCSC	uc003zcq	human. [Q6P5W5-1]
# eggNOG	COG0428	LUCA
# eggNOG	KOG2693	Eukaryota
BLAST	swissprot:S39A4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S39A4_HUMAN
COXPRESdb	55630	http://coxpresdb.jp/data/gene/55630.shtml
CleanEx	HS_SLC39A4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC39A4
DOI	10.1038/nature04406	http://dx.doi.org/10.1038/nature04406
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/ng913	http://dx.doi.org/10.1038/ng913
DOI	10.1046/j.1523-1747.2003.12243.x	http://dx.doi.org/10.1046/j.1523-1747.2003.12243.x
DOI	10.1074/jbc.M310799200	http://dx.doi.org/10.1074/jbc.M310799200
DOI	10.1086/341125	http://dx.doi.org/10.1086/341125
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AF205589	http://www.ebi.ac.uk/ena/data/view/AF205589
EMBL	AK000334	http://www.ebi.ac.uk/ena/data/view/AK000334
EMBL	AK025537	http://www.ebi.ac.uk/ena/data/view/AK025537
EMBL	BC001688	http://www.ebi.ac.uk/ena/data/view/BC001688
EMBL	BC062625	http://www.ebi.ac.uk/ena/data/view/BC062625
Ensembl	ENST00000301305	http://www.ensembl.org/id/ENST00000301305
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016023	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016023
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0055038	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055038
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005385
GO_process	GO:0006882	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006882
GO_process	GO:0034224	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034224
GO_process	GO:0071578	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071578
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC39A4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC39A4
GeneID	55630	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55630
H-InvDB	HIX0007856	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0007856
HGNC	HGNC:17129	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17129
HOGENOM	HOG000293181	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000293181&db=HOGENOM6
HOVERGEN	HBG062532	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG062532&db=HOVERGEN
InParanoid	Q6P5W5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6P5W5
InterPro	IPR003689	http://www.ebi.ac.uk/interpro/entry/IPR003689
Jabion	55630	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55630
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00212	http://www.genome.jp/dbget-bin/www_bget?H00212
KEGG_Gene	hsa:55630	http://www.genome.jp/dbget-bin/www_bget?hsa:55630
KEGG_Orthology	KO:K14710	http://www.genome.jp/dbget-bin/www_bget?KO:K14710
KEGG_Pathway	ko04978	http://www.genome.jp/kegg-bin/show_pathway?ko04978
MIM	201100	http://www.ncbi.nlm.nih.gov/omim/201100
MIM	607059	http://www.ncbi.nlm.nih.gov/omim/607059
Orphanet	37	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=37
OrthoDB	EOG091G04FT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G04FT
PSORT	swissprot:S39A4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S39A4_HUMAN
PSORT-B	swissprot:S39A4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S39A4_HUMAN
PSORT2	swissprot:S39A4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S39A4_HUMAN
Pfam	PF02535	http://pfam.xfam.org/family/PF02535
PharmGKB	PA38204	http://www.pharmgkb.org/do/serve?objId=PA38204&objCls=Gene
Phobius	swissprot:S39A4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S39A4_HUMAN
PhylomeDB	Q6P5W5	http://phylomedb.org/?seqid=Q6P5W5
ProteinModelPortal	Q6P5W5	http://www.proteinmodelportal.org/query/uniprot/Q6P5W5
PubMed	12032886	http://www.ncbi.nlm.nih.gov/pubmed/12032886
PubMed	12068297	http://www.ncbi.nlm.nih.gov/pubmed/12068297
PubMed	12787121	http://www.ncbi.nlm.nih.gov/pubmed/12787121
PubMed	14612438	http://www.ncbi.nlm.nih.gov/pubmed/14612438
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16421571	http://www.ncbi.nlm.nih.gov/pubmed/16421571
Reactome	R-HSA-442380	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442380
RefSeq	NP_060237	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060237
RefSeq	NP_570901	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_570901
SMR	Q6P5W5	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q6P5W5
STRING	9606.ENSP00000301305	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000301305&targetmode=cogs
TCDB	2.A.5.4	http://www.tcdb.org/search/result.php?tc=2.A.5.4
UCSC	uc003zcq	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003zcq&org=rat
UniGene	Hs.521934	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.521934
UniProtKB	S39A4_HUMAN	http://www.uniprot.org/uniprot/S39A4_HUMAN
UniProtKB-AC	Q6P5W5	http://www.uniprot.org/uniprot/Q6P5W5
charge	swissprot:S39A4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S39A4_HUMAN
eggNOG	COG0428	http://eggnogapi.embl.de/nog_data/html/tree/COG0428
eggNOG	KOG2693	http://eggnogapi.embl.de/nog_data/html/tree/KOG2693
epestfind	swissprot:S39A4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S39A4_HUMAN
garnier	swissprot:S39A4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S39A4_HUMAN
helixturnhelix	swissprot:S39A4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S39A4_HUMAN
hmoment	swissprot:S39A4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S39A4_HUMAN
iep	swissprot:S39A4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S39A4_HUMAN
inforesidue	swissprot:S39A4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S39A4_HUMAN
neXtProt	NX_Q6P5W5	http://www.nextprot.org/db/entry/NX_Q6P5W5
octanol	swissprot:S39A4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S39A4_HUMAN
pepcoil	swissprot:S39A4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S39A4_HUMAN
pepdigest	swissprot:S39A4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S39A4_HUMAN
pepinfo	swissprot:S39A4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S39A4_HUMAN
pepnet	swissprot:S39A4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S39A4_HUMAN
pepstats	swissprot:S39A4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S39A4_HUMAN
pepwheel	swissprot:S39A4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S39A4_HUMAN
pepwindow	swissprot:S39A4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S39A4_HUMAN
sigcleave	swissprot:S39A4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S39A4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S35B3_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9H1N7-1; Sequence=Displayed; Name=2; IsoId=Q9H1N7-2; Sequence=VSP_016193, VSP_016194; Note=No experimental confirmation available.; Name=3; IsoId=Q9H1N7-3; Sequence=VSP_016195, VSP_016196; Note=No experimental confirmation available.; 
# AltName	S35B3_HUMAN	3'-phosphoadenosine 5'-phosphosulfate transporter
# AltName	S35B3_HUMAN	PAPS transporter 2
# AltName	S35B3_HUMAN	Solute carrier family 35 member B3
# BIOPHYSICOCHEMICAL PROPERTIES	Kinetic parameters: KM=2.2 uM for PAPS {ECO	0000269|PubMed:16492677}; 
# BioGrid	119208	2
# CCDS	CCDS4508	-. [Q9H1N7-1]
# ChiTaRS	SLC35B3	human
# Ensembl	ENST00000379660	ENSP00000368981; ENSG00000124786. [Q9H1N7-1]
# ExpressionAtlas	Q9H1N7	baseline and differential
# FUNCTION	S35B3_HUMAN	Mediates the transport of adenosine 3'-phospho 5'- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon. {ECO 0000269|PubMed 16492677}. 
# GO_component	GO:0000139	Golgi membrane; TAS:Reactome.
# GO_component	GO:0030173	integral component of Golgi membrane; IBA:GO_Central.
# GO_component	GO:0030176	integral component of endoplasmic reticulum membrane; IBA:GO_Central.
# GO_function	GO:0046964	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0050428	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006790	sulfur compound metabolic process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# Genevisible	Q9H1N7	HS
# HGNC	HGNC:21601	SLC35B3
# InterPro	IPR013657	UAA
# KEGG_Brite	ko02001	Solute carrier family
# MIM	610845	gene
# Organism	S35B3_HUMAN	Homo sapiens (Human)
# Pfam	PF08449	UAA
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-174362	Transport and synthesis of PAPS
# Reactome	R-HSA-727802	Transport of nucleotide sugars
# RecName	S35B3_HUMAN	Adenosine 3'-phospho 5'-phosphosulfate transporter 2
# RefSeq	NP_001136013	NM_001142541.2. [Q9H1N7-1]
# RefSeq	NP_057032	NM_015948.4. [Q9H1N7-1]
# RefSeq	XP_005249214	XM_005249157.2. [Q9H1N7-1]
# RefSeq	XP_006715165	XM_006715102.3. [Q9H1N7-1]
# RefSeq	XP_016866399	XM_017010910.1. [Q9H1N7-1]
# RefSeq	XP_016866400	XM_017010911.1. [Q9H1N7-1]
# SEQUENCE CAUTION	Sequence=AAD27728.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=CAE46041.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the nucleotide-sugar transporter family. SLC35B subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S35B3_HUMAN	Golgi apparatus membrane {ECO 0000269|PubMed 16492677}; Multi-pass membrane protein {ECO 0000269|PubMed 16492677}. 
# TCDB	2.A.7.11	the drug/metabolite transporter (dmt) superfamily
# TISSUE SPECIFICITY	Preferentially and highly expressed in colon. {ECO:0000269|PubMed	16492677}. 
# UCSC	uc003myb	human. [Q9H1N7-1]
# eggNOG	COG0697	LUCA
# eggNOG	KOG1582	Eukaryota
BLAST	swissprot:S35B3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S35B3_HUMAN
BioCyc	ZFISH:ENSG00000124786-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000124786-MONOMER
COXPRESdb	51000	http://coxpresdb.jp/data/gene/51000.shtml
CleanEx	HS_SLC35B3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC35B3
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1074/jbc.M508991200	http://dx.doi.org/10.1074/jbc.M508991200
DOI	10.1101/gr.10.5.703	http://dx.doi.org/10.1101/gr.10.5.703
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AB231931	http://www.ebi.ac.uk/ena/data/view/AB231931
EMBL	AF132953	http://www.ebi.ac.uk/ena/data/view/AF132953
EMBL	AL355815	http://www.ebi.ac.uk/ena/data/view/AL355815
EMBL	BC006973	http://www.ebi.ac.uk/ena/data/view/BC006973
EMBL	BX538271	http://www.ebi.ac.uk/ena/data/view/BX538271
EMBL	BX641086	http://www.ebi.ac.uk/ena/data/view/BX641086
Ensembl	ENST00000379660	http://www.ensembl.org/id/ENST00000379660
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0030173	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030173
GO_component	GO:0030176	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030176
GO_function	GO:0046964	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046964
GO_process	GO:0050428	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050428
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GeneCards	SLC35B3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC35B3
GeneID	51000	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51000
GeneTree	ENSGT00530000063090	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063090
HGNC	HGNC:21601	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:21601
HOGENOM	HOG000006136	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006136&db=HOGENOM6
HOVERGEN	HBG066829	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG066829&db=HOVERGEN
HPA	HPA054661	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA054661
HPA	HPA057801	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA057801
IntAct	Q9H1N7	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9H1N7*
InterPro	IPR013657	http://www.ebi.ac.uk/interpro/entry/IPR013657
Jabion	51000	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=51000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:51000	http://www.genome.jp/dbget-bin/www_bget?hsa:51000
KEGG_Orthology	KO:K15277	http://www.genome.jp/dbget-bin/www_bget?KO:K15277
MIM	610845	http://www.ncbi.nlm.nih.gov/omim/610845
OMA	FTFQYIW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FTFQYIW
OrthoDB	EOG091G0CL7	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0CL7
PSORT	swissprot:S35B3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S35B3_HUMAN
PSORT-B	swissprot:S35B3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S35B3_HUMAN
PSORT2	swissprot:S35B3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S35B3_HUMAN
Pfam	PF08449	http://pfam.xfam.org/family/PF08449
PharmGKB	PA134889889	http://www.pharmgkb.org/do/serve?objId=PA134889889&objCls=Gene
Phobius	swissprot:S35B3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S35B3_HUMAN
PhylomeDB	Q9H1N7	http://phylomedb.org/?seqid=Q9H1N7
ProteinModelPortal	Q9H1N7	http://www.proteinmodelportal.org/query/uniprot/Q9H1N7
PubMed	10810093	http://www.ncbi.nlm.nih.gov/pubmed/10810093
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16492677	http://www.ncbi.nlm.nih.gov/pubmed/16492677
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
Reactome	R-HSA-174362	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-174362
Reactome	R-HSA-727802	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-727802
RefSeq	NP_001136013	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001136013
RefSeq	NP_057032	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_057032
RefSeq	XP_005249214	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005249214
RefSeq	XP_006715165	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006715165
RefSeq	XP_016866399	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016866399
RefSeq	XP_016866400	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016866400
STRING	9606.ENSP00000368981	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000368981&targetmode=cogs
TCDB	2.A.7.11	http://www.tcdb.org/search/result.php?tc=2.A.7.11
UCSC	uc003myb	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003myb&org=rat
UniGene	Hs.285847	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.285847
UniProtKB	S35B3_HUMAN	http://www.uniprot.org/uniprot/S35B3_HUMAN
UniProtKB-AC	Q9H1N7	http://www.uniprot.org/uniprot/Q9H1N7
charge	swissprot:S35B3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S35B3_HUMAN
eggNOG	COG0697	http://eggnogapi.embl.de/nog_data/html/tree/COG0697
eggNOG	KOG1582	http://eggnogapi.embl.de/nog_data/html/tree/KOG1582
epestfind	swissprot:S35B3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S35B3_HUMAN
garnier	swissprot:S35B3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S35B3_HUMAN
helixturnhelix	swissprot:S35B3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S35B3_HUMAN
hmoment	swissprot:S35B3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S35B3_HUMAN
iep	swissprot:S35B3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S35B3_HUMAN
inforesidue	swissprot:S35B3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S35B3_HUMAN
neXtProt	NX_Q9H1N7	http://www.nextprot.org/db/entry/NX_Q9H1N7
octanol	swissprot:S35B3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S35B3_HUMAN
pepcoil	swissprot:S35B3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S35B3_HUMAN
pepdigest	swissprot:S35B3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S35B3_HUMAN
pepinfo	swissprot:S35B3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S35B3_HUMAN
pepnet	swissprot:S35B3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S35B3_HUMAN
pepstats	swissprot:S35B3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S35B3_HUMAN
pepwheel	swissprot:S35B3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S35B3_HUMAN
pepwindow	swissprot:S35B3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S35B3_HUMAN
sigcleave	swissprot:S35B3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S35B3_HUMAN
## Database	ID	URL or Descriptions
# AltName	IPO9_HUMAN	Ran-binding protein 9
# BioGrid	120830	82
# ChiTaRS	IPO9	human
# Ensembl	ENST00000361565	ENSP00000354742; ENSG00000198700
# ExpressionAtlas	Q96P70	baseline and differential
# FUNCTION	IPO9_HUMAN	Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of H2B histone (By similarity), RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones (By similarity), RPL4 and RPL6. {ECO 0000250, ECO 0000269|PubMed 11823430}. 
# GO_component	GO:0005635	nuclear envelope; IBA:GO_Central.
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005829	cytosol; IBA:GO_Central.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_function	GO:0008565	protein transporter activity; IDA:UniProtKB.
# GO_function	GO:0042393	histone binding; ISS:UniProtKB.
# GO_process	GO:0006606	protein import into nucleus; NAS:UniProtKB.
# GO_process	GO:0042991	transcription factor import into nucleus; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005635	nuclear envelope
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0042393	histone binding
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# Gene3D	1.25.10.10	-; 3.
# Genevisible	Q96P70	HS
# HGNC	HGNC:19425	IPO9
# IntAct	Q96P70	23
# InterPro	IPR001494	Importin-beta_N
# InterPro	IPR011989	ARM-like
# InterPro	IPR016024	ARM-type_fold
# Organism	IPO9_HUMAN	Homo sapiens (Human)
# PROSITE	PS50166	IMPORTIN_B_NT
# Pfam	PF03810	IBN_N
# Proteomes	UP000005640	Chromosome 1
# RecName	IPO9_HUMAN	Importin-9
# RefSeq	NP_060555	NM_018085.4
# SEQUENCE CAUTION	IPO9_HUMAN	Sequence=AAF28951.1; Type=Frameshift; Positions=982; Evidence={ECO 0000305}; Sequence=BAA86506.1; Type=Erroneous initiation; Evidence={ECO 0000305}; Sequence=BAA91588.1; Type=Erroneous initiation; Evidence={ECO 0000305}; Sequence=BAB55181.1; Type=Erroneous initiation; Evidence={ECO 0000305}; Sequence=BAC11173.1; Type=Erroneous initiation; Evidence={ECO 0000305};
# SIMILARITY	Belongs to the importin beta family. {ECO	0000305}. 
# SIMILARITY	Contains 1 importin N-terminal domain. {ECO:0000255|PROSITE-ProRule	PRU00115}. 
# SMART	SM00913	IBN_N
# SUBCELLULAR LOCATION	IPO9_HUMAN	Cytoplasm {ECO 0000250}. Nucleus {ECO 0000250}. 
# SUBUNIT	IPO9_HUMAN	Binds with high affinity to RPS7 and RPL18A. The binding is coupled to RanGTP cycles. May bind H2A, H3, H4 histones (By similarity), RPL4 and RPL6 with low affinity. Interacts with PPP2R1A and PPP2R1B. {ECO 0000250, ECO 0000269|PubMed 11823430, ECO 0000269|PubMed 12670497}. 
# SUPFAM	SSF48371	SSF48371; 2
# TCDB	1.I.1.1	the nuclear pore complex (npc) family
# UCSC	uc001gwz	human
# eggNOG	COG5657	LUCA
# eggNOG	KOG2274	Eukaryota
BLAST	swissprot:IPO9_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:IPO9_HUMAN
COXPRESdb	55705	http://coxpresdb.jp/data/gene/55705.shtml
CleanEx	HS_IPO9	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_IPO9
CleanEx	HS_RANBP9	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_RANBP9
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/S0006-291X(03)00434-0	http://dx.doi.org/10.1016/S0006-291X(03)00434-0
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/mcp.M111.015131	http://dx.doi.org/10.1074/mcp.M111.015131
DOI	10.1093/dnares/6.5.329	http://dx.doi.org/10.1093/dnares/6.5.329
DOI	10.1093/emboj/21.3.377	http://dx.doi.org/10.1093/emboj/21.3.377
DOI	10.1101/gr.140200	http://dx.doi.org/10.1101/gr.140200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AB033018	http://www.ebi.ac.uk/ena/data/view/AB033018
EMBL	AF161391	http://www.ebi.ac.uk/ena/data/view/AF161391
EMBL	AF410465	http://www.ebi.ac.uk/ena/data/view/AF410465
EMBL	AK001264	http://www.ebi.ac.uk/ena/data/view/AK001264
EMBL	AK027532	http://www.ebi.ac.uk/ena/data/view/AK027532
EMBL	AK074740	http://www.ebi.ac.uk/ena/data/view/AK074740
EMBL	AK094603	http://www.ebi.ac.uk/ena/data/view/AK094603
EMBL	AL645504	http://www.ebi.ac.uk/ena/data/view/AL645504
EMBL	AL834323	http://www.ebi.ac.uk/ena/data/view/AL834323
EMBL	BC003604	http://www.ebi.ac.uk/ena/data/view/BC003604
EMBL	CH471067	http://www.ebi.ac.uk/ena/data/view/CH471067
Ensembl	ENST00000361565	http://www.ensembl.org/id/ENST00000361565
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0042393	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042393
GO_process	GO:0006606	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006606
GO_process	GO:0042991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042991
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0042393	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042393
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
GeneCards	IPO9	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=IPO9
GeneID	55705	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55705
GeneTree	ENSGT00390000008224	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000008224
HGNC	HGNC:19425	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:19425
HOVERGEN	HBG049054	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG049054&db=HOVERGEN
HPA	HPA054894	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA054894
HPA	HPA059540	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA059540
InParanoid	Q96P70	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96P70
IntAct	Q96P70	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96P70*
InterPro	IPR001494	http://www.ebi.ac.uk/interpro/entry/IPR001494
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
Jabion	55705	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55705
KEGG_Gene	hsa:55705	http://www.genome.jp/dbget-bin/www_bget?hsa:55705
MINT	MINT-1153224	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1153224
OMA	GAEHWWK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GAEHWWK
OrthoDB	EOG091G01DL	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01DL
PROSITE	PS50166	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50166
PSORT	swissprot:IPO9_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:IPO9_HUMAN
PSORT-B	swissprot:IPO9_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:IPO9_HUMAN
PSORT2	swissprot:IPO9_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:IPO9_HUMAN
Pfam	PF03810	http://pfam.xfam.org/family/PF03810
PharmGKB	PA134930111	http://www.pharmgkb.org/do/serve?objId=PA134930111&objCls=Gene
Phobius	swissprot:IPO9_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:IPO9_HUMAN
PhylomeDB	Q96P70	http://phylomedb.org/?seqid=Q96P70
ProteinModelPortal	Q96P70	http://www.proteinmodelportal.org/query/uniprot/Q96P70
PubMed	10574461	http://www.ncbi.nlm.nih.gov/pubmed/10574461
PubMed	11042152	http://www.ncbi.nlm.nih.gov/pubmed/11042152
PubMed	11823430	http://www.ncbi.nlm.nih.gov/pubmed/11823430
PubMed	12670497	http://www.ncbi.nlm.nih.gov/pubmed/12670497
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22223895	http://www.ncbi.nlm.nih.gov/pubmed/22223895
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
RefSeq	NP_060555	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060555
SMART	SM00913	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00913
STRING	9606.ENSP00000354742	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000354742&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
TCDB	1.I.1.1	http://www.tcdb.org/search/result.php?tc=1.I.1.1
UCSC	uc001gwz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001gwz&org=rat
UniGene	Hs.596014	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.596014
UniProtKB	IPO9_HUMAN	http://www.uniprot.org/uniprot/IPO9_HUMAN
UniProtKB-AC	Q96P70	http://www.uniprot.org/uniprot/Q96P70
charge	swissprot:IPO9_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:IPO9_HUMAN
eggNOG	COG5657	http://eggnogapi.embl.de/nog_data/html/tree/COG5657
eggNOG	KOG2274	http://eggnogapi.embl.de/nog_data/html/tree/KOG2274
epestfind	swissprot:IPO9_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:IPO9_HUMAN
garnier	swissprot:IPO9_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:IPO9_HUMAN
helixturnhelix	swissprot:IPO9_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:IPO9_HUMAN
hmoment	swissprot:IPO9_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:IPO9_HUMAN
iep	swissprot:IPO9_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:IPO9_HUMAN
inforesidue	swissprot:IPO9_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:IPO9_HUMAN
neXtProt	NX_Q96P70	http://www.nextprot.org/db/entry/NX_Q96P70
octanol	swissprot:IPO9_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:IPO9_HUMAN
pepcoil	swissprot:IPO9_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:IPO9_HUMAN
pepdigest	swissprot:IPO9_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:IPO9_HUMAN
pepinfo	swissprot:IPO9_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:IPO9_HUMAN
pepnet	swissprot:IPO9_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:IPO9_HUMAN
pepstats	swissprot:IPO9_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:IPO9_HUMAN
pepwheel	swissprot:IPO9_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:IPO9_HUMAN
pepwindow	swissprot:IPO9_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:IPO9_HUMAN
sigcleave	swissprot:IPO9_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:IPO9_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNA4_HUMAN	HPCN2
# AltName	KCNA4_HUMAN	Voltage-gated potassium channel HBK4
# AltName	KCNA4_HUMAN	Voltage-gated potassium channel subunit Kv1.4
# AltName	Voltage-gated K(+) channel HuKII {ECO:0000303|PubMed	19912772}
# AltName	Voltage-gated potassium channel HK1 {ECO:0000303|PubMed	2001794}
# BioGrid	109942	18
# DOMAIN	KCNA4_HUMAN	The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. {ECO 0000250|UniProtKB Q28527}. 
# DOMAIN	KCNA4_HUMAN	The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. {ECO 0000250|UniProtKB P63142}. 
# DrugBank	DB06637	Dalfampridine
# ENZYME REGULATION	Inhibited by 4-aminopyridine (4-AP), but not by tetraethylammonium (TEA) and charybdotoxin (CTX). {ECO:0000269|PubMed	19912772}. 
# Ensembl	ENST00000328224	ENSP00000328511; ENSG00000182255
# FUNCTION	KCNA4_HUMAN	Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed 19912772, PubMed 8495559). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed 8495559). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed 19912772, PubMed 8495559). Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed 17156368). {ECO 0000269|PubMed 17156368, ECO 0000269|PubMed 19912772, ECO 0000269|PubMed 8495559}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IMP:UniProtKB.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IMP:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; ISS:UniProtKB.
# GO_component	GO:0030424	axon; ISS:UniProtKB.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IDA:UniProtKB.
# GO_function	GO:0030955	potassium ion binding; IEA:InterPro.
# GO_process	GO:0006813	potassium ion transport; TAS:ProtInc.
# GO_process	GO:0051260	protein homooligomerization; IEA:InterPro.
# GO_process	GO:0071805	potassium ion transmembrane transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.350	-; 1.
# Gene3D	1.20.5.600	-; 1.
# Genevisible	P22459	HS
# HGNC	HGNC:6222	KCNA4
# INTERACTION	KCNA4_HUMAN	Q62936 Dlg3 (xeno); NbExp=4; IntAct=EBI-631235, EBI-349596; P78352 DLG4; NbExp=2; IntAct=EBI-631235, EBI-80389; P31016 Dlg4 (xeno); NbExp=3; IntAct=EBI-631235, EBI-375655; P21673 SAT1; NbExp=3; IntAct=EBI-631235, EBI-711613; 
# IntAct	P22459	6
# InterPro	IPR000210	BTB/POZ_dom
# InterPro	IPR003131	T1-type_BTB
# InterPro	IPR003968	K_chnl_volt-dep_Kv
# InterPro	IPR003972	K_chnl_volt-dep_Kv1
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR011333	SKP1/BTB/POZ
# InterPro	IPR012897	K_chnl_volt-dep_Kv1.4_TID
# InterPro	IPR020467	K_chnl_volt-dep_Kv1.4
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko04040	Ion channels
# MIM	176266	gene
# Organism	KCNA4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11537	PTHR11537
# PIR	A39922	A39922
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01491	KVCHANNEL
# PRINTS	PR01496	SHAKERCHANEL
# PRINTS	PR01511	KV14CHANNEL
# Pfam	PF00520	Ion_trans
# Pfam	PF02214	BTB_2
# Pfam	PF07941	K_channel_TID
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# RecName	KCNA4_HUMAN	Potassium voltage-gated channel subfamily A member 4
# RefSeq	NP_002224	NM_002233.3
# SIMILARITY	Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily. {ECO	0000305}.
# SMART	SM00225	BTB
# SUBCELLULAR LOCATION	KCNA4_HUMAN	Cell membrane {ECO 0000269|PubMed 17156368, ECO 0000269|PubMed 19912772, ECO 0000269|PubMed 19968958, ECO 0000269|PubMed 8495559}; Multi-pass membrane protein {ECO 0000255}. Cell projection, axon {ECO 0000250|UniProtKB P15385}. 
# SUBUNIT	Homotetramer and heterotetramer of potassium channel proteins (By similarity). Interacts with KCNAB1 and KCNAB2 (By similarity). Binds PDZ domains of DLG1, DLG2 and DLG4 (By similarity). Interacts with SIGMAR1 (By similarity). Detected in a complex with KCNA1 (By similarity). Interacts with KCNA2 (By similarity). Part of a complex containing KCNA1, KCNAB1 and LGI1 (By similarity). Interacts (via cytoplasmic N-terminal domain) with KCNRG (PubMed:19968958). {ECO	0000250|UniProtKB:P15385}. 
# SUPFAM	SSF54695	SSF54695
# TISSUE SPECIFICITY	Detected in heart ventricle. {ECO:0000269|PubMed	2001794}. 
# UCSC	uc001msk	human
# eggNOG	COG1226	LUCA
# eggNOG	KOG1545	Eukaryota
BLAST	swissprot:KCNA4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNA4_HUMAN
BioCyc	ZFISH:G66-32799-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32799-MONOMER
COXPRESdb	3739	http://coxpresdb.jp/data/gene/3739.shtml
CleanEx	HS_KCNA4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNA4
DOI	10.1016/1044-7431(90)90004-N	http://dx.doi.org/10.1016/1044-7431(90)90004-N
DOI	10.1016/j.bbrc.2009.11.143	http://dx.doi.org/10.1016/j.bbrc.2009.11.143
DOI	10.1038/385272a0	http://dx.doi.org/10.1038/385272a0
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1093/nar/18.23.7160	http://dx.doi.org/10.1093/nar/18.23.7160
DOI	10.1111/j.1460-9568.2006.05186.x	http://dx.doi.org/10.1111/j.1460-9568.2006.05186.x
DOI	10.1161/01.RES.72.6.1326	http://dx.doi.org/10.1161/01.RES.72.6.1326
DrugBank	DB06637	http://www.drugbank.ca/drugs/DB06637
EMBL	AC124657	http://www.ebi.ac.uk/ena/data/view/AC124657
EMBL	L02751	http://www.ebi.ac.uk/ena/data/view/L02751
EMBL	M55514	http://www.ebi.ac.uk/ena/data/view/M55514
EMBL	M60450	http://www.ebi.ac.uk/ena/data/view/M60450
Ensembl	ENST00000328224	http://www.ensembl.org/id/ENST00000328224
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030424	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030424
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0030955	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030955
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
Gene3D	1.20.5.600	http://www.cathdb.info/version/latest/superfamily/1.20.5.600
GeneCards	KCNA4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNA4
GeneID	3739	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3739
GeneTree	ENSGT00760000118846	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118846
H-InvDB	HIX0036152	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0036152
HGNC	HGNC:6222	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6222
HOGENOM	HOG000231015	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231015&db=HOGENOM6
HOVERGEN	HBG052230	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052230&db=HOVERGEN
HPA	CAB001977	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB001977
HPA	HPA016422	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA016422
InParanoid	P22459	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P22459
IntAct	P22459	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P22459*
InterPro	IPR000210	http://www.ebi.ac.uk/interpro/entry/IPR000210
InterPro	IPR003131	http://www.ebi.ac.uk/interpro/entry/IPR003131
InterPro	IPR003968	http://www.ebi.ac.uk/interpro/entry/IPR003968
InterPro	IPR003972	http://www.ebi.ac.uk/interpro/entry/IPR003972
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR011333	http://www.ebi.ac.uk/interpro/entry/IPR011333
InterPro	IPR012897	http://www.ebi.ac.uk/interpro/entry/IPR012897
InterPro	IPR020467	http://www.ebi.ac.uk/interpro/entry/IPR020467
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	3739	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3739
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3739	http://www.genome.jp/dbget-bin/www_bget?hsa:3739
KEGG_Orthology	KO:K04877	http://www.genome.jp/dbget-bin/www_bget?KO:K04877
MIM	176266	http://www.ncbi.nlm.nih.gov/omim/176266
MINT	MINT-200816	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-200816
OMA	KKAHHRQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KKAHHRQ
OrthoDB	EOG091G10NU	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G10NU
PANTHER	PTHR11537	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01491	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01491
PRINTS	PR01496	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01496
PRINTS	PR01511	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01511
PSORT	swissprot:KCNA4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNA4_HUMAN
PSORT-B	swissprot:KCNA4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNA4_HUMAN
PSORT2	swissprot:KCNA4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNA4_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF02214	http://pfam.xfam.org/family/PF02214
Pfam	PF07941	http://pfam.xfam.org/family/PF07941
PharmGKB	PA207	http://www.pharmgkb.org/do/serve?objId=PA207&objCls=Gene
Phobius	swissprot:KCNA4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNA4_HUMAN
PhylomeDB	P22459	http://phylomedb.org/?seqid=P22459
ProteinModelPortal	P22459	http://www.proteinmodelportal.org/query/uniprot/P22459
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	17156368	http://www.ncbi.nlm.nih.gov/pubmed/17156368
PubMed	19912772	http://www.ncbi.nlm.nih.gov/pubmed/19912772
PubMed	19968958	http://www.ncbi.nlm.nih.gov/pubmed/19968958
PubMed	2001794	http://www.ncbi.nlm.nih.gov/pubmed/2001794
PubMed	2263489	http://www.ncbi.nlm.nih.gov/pubmed/2263489
PubMed	8495559	http://www.ncbi.nlm.nih.gov/pubmed/8495559
PubMed	9000078	http://www.ncbi.nlm.nih.gov/pubmed/9000078
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
RefSeq	NP_002224	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002224
SMART	SM00225	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225
SMR	P22459	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P22459
STRING	9606.ENSP00000328511	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000328511&targetmode=cogs
SUPFAM	SSF54695	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54695
UCSC	uc001msk	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001msk&org=rat
UniGene	Hs.592002	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.592002
UniProtKB	KCNA4_HUMAN	http://www.uniprot.org/uniprot/KCNA4_HUMAN
UniProtKB-AC	P22459	http://www.uniprot.org/uniprot/P22459
charge	swissprot:KCNA4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNA4_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG1545	http://eggnogapi.embl.de/nog_data/html/tree/KOG1545
epestfind	swissprot:KCNA4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNA4_HUMAN
garnier	swissprot:KCNA4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNA4_HUMAN
helixturnhelix	swissprot:KCNA4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNA4_HUMAN
hmoment	swissprot:KCNA4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNA4_HUMAN
iep	swissprot:KCNA4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNA4_HUMAN
inforesidue	swissprot:KCNA4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNA4_HUMAN
neXtProt	NX_P22459	http://www.nextprot.org/db/entry/NX_P22459
octanol	swissprot:KCNA4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNA4_HUMAN
pepcoil	swissprot:KCNA4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNA4_HUMAN
pepdigest	swissprot:KCNA4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNA4_HUMAN
pepinfo	swissprot:KCNA4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNA4_HUMAN
pepnet	swissprot:KCNA4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNA4_HUMAN
pepstats	swissprot:KCNA4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNA4_HUMAN
pepwheel	swissprot:KCNA4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNA4_HUMAN
pepwindow	swissprot:KCNA4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNA4_HUMAN
sigcleave	swissprot:KCNA4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNA4_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNE2_HUMAN	MinK-related peptide 1
# AltName	KCNE2_HUMAN	Minimum potassium ion channel-related peptide 1
# AltName	KCNE2_HUMAN	Potassium channel subunit beta MiRP1
# BioGrid	115313	2
# DISEASE	KCNE2_HUMAN	Atrial fibrillation, familial, 4 (ATFB4) [MIM 611493]  A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. {ECO 0000269|PubMed 15368194}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	KCNE2_HUMAN	Long QT syndrome 6 (LQT6) [MIM 613693]  A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. {ECO 0000269|PubMed 10219239, ECO 0000269|PubMed 12185453, ECO 0000269|PubMed 16922724, ECO 0000269|PubMed 19716085}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000290310	ENSP00000290310; ENSG00000159197
# FUNCTION	KCNE2_HUMAN	Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with HCN1 and HCN2 and increase potassium current. Interacts with KCNQ1; forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed 11101505). {ECO 0000250|UniProtKB P63161, ECO 0000269|PubMed 10219239, ECO 0000269|PubMed 11101505}. 
# GO_component	GO:0005764	lysosome; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IDA:BHF-UCL.
# GO_component	GO:0009986	cell surface; IDA:BHF-UCL.
# GO_function	GO:0005242	inward rectifier potassium channel activity; IEA:Ensembl.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; IEA:Ensembl.
# GO_function	GO:0015459	potassium channel regulator activity; IDA:UniProtKB.
# GO_function	GO:0044325	ion channel binding; IDA:BHF-UCL.
# GO_function	GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization; IMP:BHF-UCL.
# GO_process	GO:0007568	aging; IEA:Ensembl.
# GO_process	GO:0010107	potassium ion import; IMP:BHF-UCL.
# GO_process	GO:0035690	cellular response to drug; IDA:BHF-UCL.
# GO_process	GO:0043586	tongue development; IEA:Ensembl.
# GO_process	GO:0060306	regulation of membrane repolarization; IDA:BHF-UCL.
# GO_process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization; IMP:BHF-UCL.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:0071435	potassium ion export; IDA:BHF-UCL.
# GO_process	GO:0071805	potassium ion transmembrane transport; IDA:BHF-UCL.
# GO_process	GO:0086002	cardiac muscle cell action potential involved in contraction; IMP:BHF-UCL.
# GO_process	GO:0086005	ventricular cardiac muscle cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086009	membrane repolarization; IDA:BHF-UCL.
# GO_process	GO:0086011	membrane repolarization during action potential; IMP:BHF-UCL.
# GO_process	GO:0086091	regulation of heart rate by cardiac conduction; IMP:BHF-UCL.
# GO_process	GO:0098915	membrane repolarization during ventricular cardiac muscle cell action potential; IMP:BHF-UCL.
# GO_process	GO:1901379	regulation of potassium ion transmembrane transport; IDA:BHF-UCL.
# GO_process	GO:1901387	positive regulation of voltage-gated calcium channel activity; IEA:Ensembl.
# GO_process	GO:1901800	positive regulation of proteasomal protein catabolic process; IDA:BHF-UCL.
# GO_process	GO:1901979	regulation of inward rectifier potassium channel activity; IDA:BHF-UCL.
# GO_process	GO:1902159	regulation of cyclic nucleotide-gated ion channel activity; IEA:Ensembl.
# GO_process	GO:1902259	regulation of delayed rectifier potassium channel activity; IDA:BHF-UCL.
# GO_process	GO:1902260	negative regulation of delayed rectifier potassium channel activity; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005764	lysosome
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0007568	aging
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9Y6J6	HS
# HGNC	HGNC:6242	KCNE2
# InterPro	IPR000369	K_chnl_KCNE
# InterPro	IPR005425	K_chnl_volt-dep_bsu_KCNE2
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00720	[Cardiovascular disease] Jervell and Lange-Nielsen syndrome (JLNS)
# KEGG_Disease	H00731	[Cardiovascular disease] Atrial fibrillation
# KEGG_Pathway	ko04971	Gastric acid secretion
# MIM	603796	gene
# MIM	611493	phenotype
# MIM	613693	phenotype
# Organism	KCNE2_HUMAN	Homo sapiens (Human)
# Orphanet	101016	Romano-Ward syndrome
# Orphanet	334	Familial atrial fibrillation
# PDB	2M0Q	NMR; -; A=1-123
# PRINTS	PR01605	KCNE2CHANNEL
# Pfam	PF02060	ISK_Channel
# Proteomes	UP000005640	Chromosome 21
# Reactome	R-HSA-5576890	Phase 3 - rapid repolarisation
# Reactome	R-HSA-5576893	Phase 2 - plateau phase
# RecName	KCNE2_HUMAN	Potassium voltage-gated channel subfamily E member 2
# RefSeq	NP_751951	NM_172201.1
# SIMILARITY	Belongs to the potassium channel KCNE family. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCNE2_HUMAN	Cell membrane {ECO 0000269|PubMed 20533308}; Single-pass type I membrane protein {ECO 0000250|UniProtKB P63161}. Note=Colocalizes with KCNB1 at the plasma membrane. {ECO 0000250|UniProtKB P63161}. 
# SUBUNIT	KCNE2_HUMAN	Interacts with KCNB1 (By similarity). Associates with KCNH2/ERG1 (PubMed 10219239). May associate with KCNQ2 and KCNQ3 (PubMed 11034315,). Associates with HCN1 and probably HCN2. Heteromultimer with KCNC2. Interacts with KCNC2 (By similarity). Interacts with KCNQ1; forms a heterooligomer complex that targets to the membrane raft and leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed 11101505, PubMed 20533308). {ECO 0000250|UniProtKB P63161, ECO 0000269|PubMed 10219239, ECO 0000269|PubMed 11034315, ECO 0000269|PubMed 11101505, ECO 0000269|PubMed 20533308}. 
# TISSUE SPECIFICITY	Highly expressed in brain, heart, skeletal muscle, pancreas, placenta, kidney, colon and thymus. A small but significant expression is found in liver, ovary, testis, prostate, small intestine and leukocytes. Very low expression, nearly undetectable, in lung and spleen. {ECO:0000269|PubMed	11034315}. 
# UCSC	uc002ytt	human
# eggNOG	ENOG410IX4Y	Eukaryota
# eggNOG	ENOG411297Y	LUCA
BLAST	swissprot:KCNE2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNE2_HUMAN
BioCyc	ZFISH:ENSG00000159197-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000159197-MONOMER
COXPRESdb	9992	http://coxpresdb.jp/data/gene/9992.shtml
CleanEx	HS_KCNE2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNE2
DOI	10.1002/jcp.22265	http://dx.doi.org/10.1002/jcp.22265
DOI	10.1007/s00109-002-0364-0	http://dx.doi.org/10.1007/s00109-002-0364-0
DOI	10.1016/S0014-5793(00)01918-9	http://dx.doi.org/10.1016/S0014-5793(00)01918-9
DOI	10.1016/S0092-8674(00)80728-X	http://dx.doi.org/10.1016/S0092-8674(00)80728-X
DOI	10.1016/j.hrthm.2009.05.021	http://dx.doi.org/10.1016/j.hrthm.2009.05.021
DOI	10.1086/425342	http://dx.doi.org/10.1086/425342
DOI	10.1093/emboj/19.23.6326	http://dx.doi.org/10.1093/emboj/19.23.6326
DOI	10.1096/fj.01-0520hyp	http://dx.doi.org/10.1096/fj.01-0520hyp
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1399-0004.2006.00671.x	http://dx.doi.org/10.1111/j.1399-0004.2006.00671.x
EMBL	AF071002	http://www.ebi.ac.uk/ena/data/view/AF071002
EMBL	AF302095	http://www.ebi.ac.uk/ena/data/view/AF302095
EMBL	BC093892	http://www.ebi.ac.uk/ena/data/view/BC093892
EMBL	BC112087	http://www.ebi.ac.uk/ena/data/view/BC112087
EMBL	CH471079	http://www.ebi.ac.uk/ena/data/view/CH471079
EMBL	DQ784804	http://www.ebi.ac.uk/ena/data/view/DQ784804
Ensembl	ENST00000290310	http://www.ensembl.org/id/ENST00000290310
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_function	GO:0005242	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005242
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_function	GO:0015459	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015459
GO_function	GO:0044325	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044325
GO_function	GO:1902282	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902282
GO_process	GO:0007568	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007568
GO_process	GO:0010107	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010107
GO_process	GO:0035690	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035690
GO_process	GO:0043586	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043586
GO_process	GO:0060306	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060306
GO_process	GO:0060307	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060307
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:0071435	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071435
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GO_process	GO:0086002	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086002
GO_process	GO:0086005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086005
GO_process	GO:0086009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086009
GO_process	GO:0086011	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086011
GO_process	GO:0086091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086091
GO_process	GO:0098915	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098915
GO_process	GO:1901379	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901379
GO_process	GO:1901387	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901387
GO_process	GO:1901800	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901800
GO_process	GO:1901979	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901979
GO_process	GO:1902159	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902159
GO_process	GO:1902259	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902259
GO_process	GO:1902260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902260
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0007568	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007568
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	KCNE2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNE2
GeneID	9992	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9992
GeneTree	ENSGT00510000048894	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00510000048894
HGNC	HGNC:6242	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6242
HOGENOM	HOG000113208	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000113208&db=HOGENOM6
HOVERGEN	HBG052227	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052227&db=HOVERGEN
HPA	HPA029706	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA029706
HPA	HPA051553	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA051553
InParanoid	Q9Y6J6	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y6J6
InterPro	IPR000369	http://www.ebi.ac.uk/interpro/entry/IPR000369
InterPro	IPR005425	http://www.ebi.ac.uk/interpro/entry/IPR005425
Jabion	9992	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9992
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00720	http://www.genome.jp/dbget-bin/www_bget?H00720
KEGG_Disease	H00731	http://www.genome.jp/dbget-bin/www_bget?H00731
KEGG_Gene	hsa:9992	http://www.genome.jp/dbget-bin/www_bget?hsa:9992
KEGG_Orthology	KO:K04896	http://www.genome.jp/dbget-bin/www_bget?KO:K04896
KEGG_Pathway	ko04971	http://www.genome.jp/kegg-bin/show_pathway?ko04971
MIM	603796	http://www.ncbi.nlm.nih.gov/omim/603796
MIM	611493	http://www.ncbi.nlm.nih.gov/omim/611493
MIM	613693	http://www.ncbi.nlm.nih.gov/omim/613693
OMA	NWRRNTT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NWRRNTT
Orphanet	101016	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=101016
Orphanet	334	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=334
OrthoDB	EOG091G0UDJ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0UDJ
PDB	2M0Q	http://www.ebi.ac.uk/pdbe-srv/view/entry/2M0Q
PDBsum	2M0Q	http://www.ebi.ac.uk/pdbsum/2M0Q
PRINTS	PR01605	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01605
PSORT	swissprot:KCNE2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNE2_HUMAN
PSORT-B	swissprot:KCNE2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNE2_HUMAN
PSORT2	swissprot:KCNE2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNE2_HUMAN
Pfam	PF02060	http://pfam.xfam.org/family/PF02060
PharmGKB	PA392	http://www.pharmgkb.org/do/serve?objId=PA392&objCls=Gene
Phobius	swissprot:KCNE2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNE2_HUMAN
PhylomeDB	Q9Y6J6	http://phylomedb.org/?seqid=Q9Y6J6
ProteinModelPortal	Q9Y6J6	http://www.proteinmodelportal.org/query/uniprot/Q9Y6J6
PubMed	10219239	http://www.ncbi.nlm.nih.gov/pubmed/10219239
PubMed	11034315	http://www.ncbi.nlm.nih.gov/pubmed/11034315
PubMed	11101505	http://www.ncbi.nlm.nih.gov/pubmed/11101505
PubMed	11874988	http://www.ncbi.nlm.nih.gov/pubmed/11874988
PubMed	12185453	http://www.ncbi.nlm.nih.gov/pubmed/12185453
PubMed	15368194	http://www.ncbi.nlm.nih.gov/pubmed/15368194
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16922724	http://www.ncbi.nlm.nih.gov/pubmed/16922724
PubMed	19716085	http://www.ncbi.nlm.nih.gov/pubmed/19716085
PubMed	20533308	http://www.ncbi.nlm.nih.gov/pubmed/20533308
Reactome	R-HSA-5576890	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576890
Reactome	R-HSA-5576893	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576893
RefSeq	NP_751951	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_751951
SMR	Q9Y6J6	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9Y6J6
STRING	9606.ENSP00000290310	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000290310&targetmode=cogs
UCSC	uc002ytt	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ytt&org=rat
UniGene	Hs.551521	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.551521
UniGene	Hs.736062	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.736062
UniProtKB	KCNE2_HUMAN	http://www.uniprot.org/uniprot/KCNE2_HUMAN
UniProtKB-AC	Q9Y6J6	http://www.uniprot.org/uniprot/Q9Y6J6
charge	swissprot:KCNE2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNE2_HUMAN
eggNOG	ENOG410IX4Y	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IX4Y
eggNOG	ENOG411297Y	http://eggnogapi.embl.de/nog_data/html/tree/ENOG411297Y
epestfind	swissprot:KCNE2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNE2_HUMAN
garnier	swissprot:KCNE2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNE2_HUMAN
helixturnhelix	swissprot:KCNE2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNE2_HUMAN
hmoment	swissprot:KCNE2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNE2_HUMAN
iep	swissprot:KCNE2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNE2_HUMAN
inforesidue	swissprot:KCNE2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNE2_HUMAN
neXtProt	NX_Q9Y6J6	http://www.nextprot.org/db/entry/NX_Q9Y6J6
octanol	swissprot:KCNE2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNE2_HUMAN
pepcoil	swissprot:KCNE2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNE2_HUMAN
pepdigest	swissprot:KCNE2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNE2_HUMAN
pepinfo	swissprot:KCNE2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNE2_HUMAN
pepnet	swissprot:KCNE2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNE2_HUMAN
pepstats	swissprot:KCNE2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNE2_HUMAN
pepwheel	swissprot:KCNE2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNE2_HUMAN
pepwindow	swissprot:KCNE2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNE2_HUMAN
sigcleave	swissprot:KCNE2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNE2_HUMAN
## Database	ID	URL or Descriptions
# AltName	SCN7A_HUMAN	Putative voltage-gated sodium channel subunit alpha Nax
# AltName	SCN7A_HUMAN	Sodium channel protein cardiac and skeletal muscle subunit alpha
# AltName	SCN7A_HUMAN	Sodium channel protein type VII subunit alpha
# DOMAIN	SCN7A_HUMAN	The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position. {ECO 0000305}. 
# DrugBank	DB00313	Valproic Acid
# Ensembl	ENST00000409855	ENSP00000386796; ENSG00000136546
# Ensembl	ENST00000619410	ENSP00000478562; ENSG00000136546
# Ensembl	ENST00000621965	ENSP00000481734; ENSG00000136546
# ExpressionAtlas	Q01118	baseline and differential
# FUNCTION	SCN7A_HUMAN	Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. {ECO 0000305}. 
# GO_component	GO:0001518	voltage-gated sodium channel complex; IEA:InterPro.
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0097386	glial cell projection; IEA:Ensembl.
# GO_function	GO:0005248	voltage-gated sodium channel activity; TAS:ProtInc.
# GO_process	GO:0006814	sodium ion transport; TAS:ProtInc.
# GO_process	GO:0006936	muscle contraction; TAS:ProtInc.
# GO_process	GO:0019228	neuronal action potential; IBA:GO_Central.
# GO_process	GO:0055078	sodium ion homeostasis; IEA:Ensembl.
# GO_process	GO:0086010	membrane depolarization during action potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# Gene3D	1.20.120.350	-; 4.
# Genevisible	Q01118	HS
# HGNC	HGNC:10594	SCN7A
# InterPro	IPR001696	Na_channel_asu
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR010526	Na_trans_assoc
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028812	Na_channel_a7su
# KEGG_Brite	ko04040	Ion channels
# MIM	182392	gene
# Organism	SCN7A_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10037:SF14	PTHR10037:SF14
# PIR	A45380	A45380
# PRINTS	PR00170	NACHANNEL
# Pfam	PF00520	Ion_trans; 4
# Pfam	PF06512	Na_trans_assoc
# Proteomes	UP000005640	Chromosome 2
# Reactome	R-HSA-445095	Interaction between L1 and Ankyrins
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# RecName	SCN7A_HUMAN	Sodium channel protein type 7 subunit alpha
# RefSeq	NP_002967	NM_002976.3
# RefSeq	XP_006712743	XM_006712680.2
# RefSeq	XP_006712744	XM_006712681.3
# RefSeq	XP_006712745	XM_006712682.3
# RefSeq	XP_011509917	XM_011511615.2
# RefSeq	XP_016860156	XM_017004667.1
# SIMILARITY	Belongs to the sodium channel (TC 1.A.1.10) family. SCN7A subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	SCN7A_HUMAN	Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TISSUE SPECIFICITY	Heart and uterus. {ECO:0000269|PubMed	1317577}. 
# UCSC	uc002udu	human
# eggNOG	ENOG410INF4	Eukaryota
# eggNOG	ENOG410Y1Z2	LUCA
BLAST	swissprot:SCN7A_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SCN7A_HUMAN
BioCyc	ZFISH:ENSG00000136546-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000136546-MONOMER
COXPRESdb	6332	http://coxpresdb.jp/data/gene/6332.shtml
CleanEx	HS_SCN7A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SCN7A
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1073/pnas.89.11.4893	http://dx.doi.org/10.1073/pnas.89.11.4893
DrugBank	DB00313	http://www.drugbank.ca/drugs/DB00313
EMBL	AC074101	http://www.ebi.ac.uk/ena/data/view/AC074101
EMBL	AC092583	http://www.ebi.ac.uk/ena/data/view/AC092583
EMBL	M91556	http://www.ebi.ac.uk/ena/data/view/M91556
Ensembl	ENST00000409855	http://www.ensembl.org/id/ENST00000409855
Ensembl	ENST00000619410	http://www.ensembl.org/id/ENST00000619410
Ensembl	ENST00000621965	http://www.ensembl.org/id/ENST00000621965
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0001518	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001518
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0097386	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097386
GO_function	GO:0005248	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005248
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0006936	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006936
GO_process	GO:0019228	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019228
GO_process	GO:0055078	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055078
GO_process	GO:0086010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086010
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	SCN7A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SCN7A
GeneID	6332	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6332
GeneTree	ENSGT00830000128242	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00830000128242
HGNC	HGNC:10594	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10594
HOGENOM	HOG000231755	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231755&db=HOGENOM6
HOVERGEN	HBG053100	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053100&db=HOVERGEN
HPA	HPA004879	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA004879
InParanoid	Q01118	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q01118
InterPro	IPR001696	http://www.ebi.ac.uk/interpro/entry/IPR001696
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR010526	http://www.ebi.ac.uk/interpro/entry/IPR010526
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028812	http://www.ebi.ac.uk/interpro/entry/IPR028812
Jabion	6332	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6332
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:6332	http://www.genome.jp/dbget-bin/www_bget?hsa:6332
KEGG_Orthology	KO:K04839	http://www.genome.jp/dbget-bin/www_bget?KO:K04839
MIM	182392	http://www.ncbi.nlm.nih.gov/omim/182392
OMA	LEYADMI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LEYADMI
OrthoDB	EOG091G00FK	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00FK
PANTHER	PTHR10037:SF14	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10037:SF14
PRINTS	PR00170	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00170
PSORT	swissprot:SCN7A_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SCN7A_HUMAN
PSORT-B	swissprot:SCN7A_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SCN7A_HUMAN
PSORT2	swissprot:SCN7A_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SCN7A_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF06512	http://pfam.xfam.org/family/PF06512
PharmGKB	PA35008	http://www.pharmgkb.org/do/serve?objId=PA35008&objCls=Gene
Phobius	swissprot:SCN7A_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SCN7A_HUMAN
PhylomeDB	Q01118	http://phylomedb.org/?seqid=Q01118
ProteinModelPortal	Q01118	http://www.proteinmodelportal.org/query/uniprot/Q01118
PubMed	1317577	http://www.ncbi.nlm.nih.gov/pubmed/1317577
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
Reactome	R-HSA-445095	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-445095
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
RefSeq	NP_002967	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002967
RefSeq	XP_006712743	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006712743
RefSeq	XP_006712744	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006712744
RefSeq	XP_006712745	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006712745
RefSeq	XP_011509917	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011509917
RefSeq	XP_016860156	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016860156
STRING	9606.ENSP00000386796	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000386796&targetmode=cogs
UCSC	uc002udu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002udu&org=rat
UniGene	Hs.596087	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.596087
UniGene	Hs.644853	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.644853
UniProtKB	SCN7A_HUMAN	http://www.uniprot.org/uniprot/SCN7A_HUMAN
UniProtKB-AC	Q01118	http://www.uniprot.org/uniprot/Q01118
charge	swissprot:SCN7A_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SCN7A_HUMAN
eggNOG	ENOG410INF4	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410INF4
eggNOG	ENOG410Y1Z2	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y1Z2
epestfind	swissprot:SCN7A_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SCN7A_HUMAN
garnier	swissprot:SCN7A_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SCN7A_HUMAN
helixturnhelix	swissprot:SCN7A_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SCN7A_HUMAN
hmoment	swissprot:SCN7A_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SCN7A_HUMAN
iep	swissprot:SCN7A_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SCN7A_HUMAN
inforesidue	swissprot:SCN7A_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SCN7A_HUMAN
neXtProt	NX_Q01118	http://www.nextprot.org/db/entry/NX_Q01118
octanol	swissprot:SCN7A_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SCN7A_HUMAN
pepcoil	swissprot:SCN7A_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SCN7A_HUMAN
pepdigest	swissprot:SCN7A_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SCN7A_HUMAN
pepinfo	swissprot:SCN7A_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SCN7A_HUMAN
pepnet	swissprot:SCN7A_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SCN7A_HUMAN
pepstats	swissprot:SCN7A_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SCN7A_HUMAN
pepwheel	swissprot:SCN7A_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SCN7A_HUMAN
pepwindow	swissprot:SCN7A_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SCN7A_HUMAN
sigcleave	swissprot:SCN7A_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SCN7A_HUMAN
## Database	ID	URL or Descriptions
# AltName	VA0D1_HUMAN	32 kDa accessory protein
# AltName	VA0D1_HUMAN	V-ATPase 40 kDa accessory protein
# AltName	VA0D1_HUMAN	V-ATPase AC39 subunit
# AltName	VA0D1_HUMAN	Vacuolar proton pump subunit d 1
# BioGrid	114564	118
# ChiTaRS	ATP6V0D1	human
# Ensembl	ENST00000290949	ENSP00000290949; ENSG00000159720
# ExpressionAtlas	P61421	baseline and differential
# FUNCTION	VA0D1_HUMAN	Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). {ECO 0000250}. 
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005769	early endosome; IBA:GO_Central.
# GO_component	GO:0008021	synaptic vesicle; IEA:Ensembl.
# GO_component	GO:0010008	endosome membrane; TAS:Reactome.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IEA:Ensembl.
# GO_component	GO:0016471	vacuolar proton-transporting V-type ATPase complex; IDA:UniProtKB.
# GO_component	GO:0030670	phagocytic vesicle membrane; TAS:Reactome.
# GO_component	GO:0033179	proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
# GO_component	GO:0033181	plasma membrane proton-transporting V-type ATPase complex; IBA:GO_Central.
# GO_component	GO:0043679	axon terminus; IEA:Ensembl.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism; IBA:GO_Central.
# GO_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
# GO_process	GO:0007034	vacuolar transport; IBA:GO_Central.
# GO_process	GO:0007035	vacuolar acidification; IBA:GO_Central.
# GO_process	GO:0007420	brain development; IEA:Ensembl.
# GO_process	GO:0008286	insulin receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0015991	ATP hydrolysis coupled proton transport; IEA:InterPro.
# GO_process	GO:0015992	proton transport; NAS:UniProtKB.
# GO_process	GO:0016241	regulation of macroautophagy; NAS:ParkinsonsUK-UCL.
# GO_process	GO:0033572	transferrin transport; TAS:Reactome.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0036498	IRE1-mediated unfolded protein response; TAS:Reactome.
# GO_process	GO:0042384	cilium assembly; ISS:UniProtKB.
# GO_process	GO:0090383	phagosome acidification; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007034	vacuolar transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P61421	HS
# HGNC	HGNC:13724	ATP6V0D1
# IntAct	P61421	38
# InterPro	IPR002843	ATPase_V0-cplx_csu/dsu
# InterPro	IPR016727	ATPase_V0-cplx_dsu
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04142	Lysosome
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04966	Collecting duct acid secretion
# KEGG_Pathway	ko05110	Vibrio cholerae infection
# KEGG_Pathway	ko05120	Epithelial cell signaling in Helicobacter pylori infection
# KEGG_Pathway	ko05152	Tuberculosis
# KEGG_Pathway	ko05203	Viral carcinogenesis
# KEGG_Pathway	ko05323	Rheumatoid arthritis
# MIM	607028	gene
# Organism	VA0D1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11028	PTHR11028
# PIRSF	PIRSF018497	V-ATP_synth_D
# Pfam	PF01992	vATP-synt_AC39
# Proteomes	UP000005640	Chromosome 16
# Reactome	R-HSA-1222556	ROS, RNS production in response to bacteria
# Reactome	R-HSA-381038	XBP1(S) activates chaperone genes
# Reactome	R-HSA-77387	Insulin receptor recycling
# Reactome	R-HSA-917977	Transferrin endocytosis and recycling
# Reactome	R-HSA-983712	Ion channel transport
# RecName	VA0D1_HUMAN	V-type proton ATPase subunit d 1
# RefSeq	NP_004682	NM_004691.4
# SEQUENCE CAUTION	Sequence=CAA50591.1; Type=Frameshift; Positions=22, 25, 64, 66; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the V-ATPase V0D/AC39 subunit family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	VA0D1_HUMAN	Membrane {ECO 0000305|PubMed 21844891}; Peripheral membrane protein {ECO 0000305|PubMed 21844891}; Cytoplasmic side {ECO 0000305|PubMed 21844891}. Note=Localizes to centrosome and the base of the cilium. 
# SUBUNIT	V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components	 a, c, c', c'' and d). 
# SUPFAM	SSF103486	SSF103486
# TCDB	3.A.2.2	the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily
# TISSUE SPECIFICITY	VA0D1_HUMAN	Ubiquitous. {ECO 0000269|PubMed 12384298, ECO 0000269|PubMed 8250920}. 
# UCSC	uc002ete	human
# eggNOG	COG1527	LUCA
# eggNOG	KOG2957	Eukaryota
BLAST	swissprot:VA0D1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VA0D1_HUMAN
BioCyc	MetaCyc:HS08417-MONOMER	http://biocyc.org/getid?id=MetaCyc:HS08417-MONOMER
BioCyc	ZFISH:HS08417-MONOMER	http://biocyc.org/getid?id=ZFISH:HS08417-MONOMER
COG	COG1527	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1527
COXPRESdb	9114	http://coxpresdb.jp/data/gene/9114.shtml
CleanEx	HS_ATP6V0D1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP6V0D1
DIP	DIP-47435N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47435N
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/bbrc.1993.2434	http://dx.doi.org/10.1006/bbrc.1993.2434
DOI	10.1006/bbrc.2000.4003	http://dx.doi.org/10.1006/bbrc.2000.4003
DOI	10.1016/S0378-1119(02)00884-3	http://dx.doi.org/10.1016/S0378-1119(02)00884-3
DOI	10.1038/cr.2011.134	http://dx.doi.org/10.1038/cr.2011.134
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	BC008861	http://www.ebi.ac.uk/ena/data/view/BC008861
EMBL	L05087	http://www.ebi.ac.uk/ena/data/view/L05087
EMBL	X71490	http://www.ebi.ac.uk/ena/data/view/X71490
Ensembl	ENST00000290949	http://www.ensembl.org/id/ENST00000290949
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005769	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005769
GO_component	GO:0008021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008021
GO_component	GO:0010008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010008
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0016471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016471
GO_component	GO:0030670	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030670
GO_component	GO:0033179	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033179
GO_component	GO:0033181	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033181
GO_component	GO:0043679	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043679
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0008553	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008553
GO_function	GO:0046961	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046961
GO_process	GO:0007034	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007034
GO_process	GO:0007035	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007035
GO_process	GO:0007420	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007420
GO_process	GO:0008286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008286
GO_process	GO:0015991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015991
GO_process	GO:0015992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992
GO_process	GO:0016241	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016241
GO_process	GO:0033572	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033572
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0036498	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036498
GO_process	GO:0042384	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042384
GO_process	GO:0090383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090383
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007034	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007034
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ATP6V0D1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP6V0D1
GeneID	9114	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9114
GeneTree	ENSGT00390000002200	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002200
HGNC	HGNC:13724	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13724
HOGENOM	HOG000199065	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000199065&db=HOGENOM6
HOVERGEN	HBG018065	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG018065&db=HOVERGEN
HPA	HPA016938	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA016938
InParanoid	P61421	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P61421
IntAct	P61421	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P61421*
InterPro	IPR002843	http://www.ebi.ac.uk/interpro/entry/IPR002843
InterPro	IPR016727	http://www.ebi.ac.uk/interpro/entry/IPR016727
Jabion	9114	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9114
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:9114	http://www.genome.jp/dbget-bin/www_bget?hsa:9114
KEGG_Orthology	KO:K02146	http://www.genome.jp/dbget-bin/www_bget?KO:K02146
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04142	http://www.genome.jp/kegg-bin/show_pathway?ko04142
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04966	http://www.genome.jp/kegg-bin/show_pathway?ko04966
KEGG_Pathway	ko05110	http://www.genome.jp/kegg-bin/show_pathway?ko05110
KEGG_Pathway	ko05120	http://www.genome.jp/kegg-bin/show_pathway?ko05120
KEGG_Pathway	ko05152	http://www.genome.jp/kegg-bin/show_pathway?ko05152
KEGG_Pathway	ko05203	http://www.genome.jp/kegg-bin/show_pathway?ko05203
KEGG_Pathway	ko05323	http://www.genome.jp/kegg-bin/show_pathway?ko05323
MIM	607028	http://www.ncbi.nlm.nih.gov/omim/607028
MINT	MINT-5006032	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5006032
PANTHER	PTHR11028	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11028
PSORT	swissprot:VA0D1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VA0D1_HUMAN
PSORT-B	swissprot:VA0D1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VA0D1_HUMAN
PSORT2	swissprot:VA0D1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VA0D1_HUMAN
Pfam	PF01992	http://pfam.xfam.org/family/PF01992
PharmGKB	PA25150	http://www.pharmgkb.org/do/serve?objId=PA25150&objCls=Gene
Phobius	swissprot:VA0D1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VA0D1_HUMAN
PhylomeDB	P61421	http://phylomedb.org/?seqid=P61421
ProteinModelPortal	P61421	http://www.proteinmodelportal.org/query/uniprot/P61421
PubMed	11118322	http://www.ncbi.nlm.nih.gov/pubmed/11118322
PubMed	12384298	http://www.ncbi.nlm.nih.gov/pubmed/12384298
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21844891	http://www.ncbi.nlm.nih.gov/pubmed/21844891
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	8250920	http://www.ncbi.nlm.nih.gov/pubmed/8250920
Reactome	R-HSA-1222556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1222556
Reactome	R-HSA-381038	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-381038
Reactome	R-HSA-77387	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-77387
Reactome	R-HSA-917977	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917977
Reactome	R-HSA-983712	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983712
RefSeq	NP_004682	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004682
STRING	9606.ENSP00000290949	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000290949&targetmode=cogs
STRING	COG1527	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1527&targetmode=cogs
SUPFAM	SSF103486	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103486
TCDB	3.A.2.2	http://www.tcdb.org/search/result.php?tc=3.A.2.2
UCSC	uc002ete	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002ete&org=rat
UniGene	Hs.106876	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.106876
UniProtKB	VA0D1_HUMAN	http://www.uniprot.org/uniprot/VA0D1_HUMAN
UniProtKB-AC	P61421	http://www.uniprot.org/uniprot/P61421
charge	swissprot:VA0D1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VA0D1_HUMAN
eggNOG	COG1527	http://eggnogapi.embl.de/nog_data/html/tree/COG1527
eggNOG	KOG2957	http://eggnogapi.embl.de/nog_data/html/tree/KOG2957
epestfind	swissprot:VA0D1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VA0D1_HUMAN
garnier	swissprot:VA0D1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VA0D1_HUMAN
helixturnhelix	swissprot:VA0D1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VA0D1_HUMAN
hmoment	swissprot:VA0D1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VA0D1_HUMAN
iep	swissprot:VA0D1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VA0D1_HUMAN
inforesidue	swissprot:VA0D1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VA0D1_HUMAN
neXtProt	NX_P61421	http://www.nextprot.org/db/entry/NX_P61421
octanol	swissprot:VA0D1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VA0D1_HUMAN
pepcoil	swissprot:VA0D1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VA0D1_HUMAN
pepdigest	swissprot:VA0D1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VA0D1_HUMAN
pepinfo	swissprot:VA0D1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VA0D1_HUMAN
pepnet	swissprot:VA0D1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VA0D1_HUMAN
pepstats	swissprot:VA0D1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VA0D1_HUMAN
pepwheel	swissprot:VA0D1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VA0D1_HUMAN
pepwindow	swissprot:VA0D1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VA0D1_HUMAN
sigcleave	swissprot:VA0D1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VA0D1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q92796-1; Sequence=Displayed; Name=2; IsoId=Q92796-2; Sequence=VSP_035940, VSP_035941, VSP_035942; Note=No experimental confirmation available.; Name=3; IsoId=Q92796-3; Sequence=VSP_043717, VSP_035942; Note=No experimental confirmation available. Contains a N-acetylmethionine at position 1. Initiator Met-1 is removed. Contains a N-acetylmethionine at position 2. {ECO:0000244|PubMed	22814378}; 
# AltName	DLG3_HUMAN	Neuroendocrine-DLG
# AltName	DLG3_HUMAN	Synapse-associated protein 102
# AltName	DLG3_HUMAN	XLMR
# BioGrid	108085	60
# CCDS	CCDS14403	-. [Q92796-1]
# CCDS	CCDS43967	-. [Q92796-2]
# CCDS	CCDS55439	-. [Q92796-3]
# ChiTaRS	DLG3	human
# DISEASE	DLG3_HUMAN	Mental retardation, X-linked 90 (MRX90) [MIM 300850]  A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non- syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. {ECO 0000269|PubMed 15185169}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000374355	ENSP00000363475; ENSG00000082458. [Q92796-2]
# Ensembl	ENST00000374360	ENSP00000363480; ENSG00000082458. [Q92796-1]
# Ensembl	ENST00000542398	ENSP00000441393; ENSG00000082458. [Q92796-3]
# ExpressionAtlas	Q92796	baseline and differential
# FUNCTION	DLG3_HUMAN	Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. 
# GO_component	GO:0005615	extracellular space; IDA:UniProtKB.
# GO_component	GO:0005737	cytoplasm; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005923	bicellular tight junction; IEA:Ensembl.
# GO_component	GO:0014069	postsynaptic density; IBA:GO_Central.
# GO_component	GO:0016323	basolateral plasma membrane; IBA:GO_Central.
# GO_component	GO:0030426	growth cone; IEA:Ensembl.
# GO_component	GO:0032281	AMPA glutamate receptor complex; IEA:Ensembl.
# GO_component	GO:0043025	neuronal cell body; IEA:Ensembl.
# GO_component	GO:0043198	dendritic shaft; IEA:Ensembl.
# GO_component	GO:0045211	postsynaptic membrane; IBA:GO_Central.
# GO_function	GO:0004385	guanylate kinase activity; IBA:GO_Central.
# GO_function	GO:0015276	ligand-gated ion channel activity; TAS:Reactome.
# GO_function	GO:0019900	kinase binding; IDA:MGI.
# GO_function	GO:0019902	phosphatase binding; IDA:UniProtKB.
# GO_function	GO:0035255	ionotropic glutamate receptor binding; IBA:GO_Central.
# GO_process	GO:0001736	establishment of planar polarity; IEA:Ensembl.
# GO_process	GO:0007268	chemical synaptic transmission; IBA:GO_Central.
# GO_process	GO:0007399	nervous system development; IBA:GO_Central.
# GO_process	GO:0008285	negative regulation of cell proliferation; NAS:UniProtKB.
# GO_process	GO:0010923	negative regulation of phosphatase activity; IDA:UniProtKB.
# GO_process	GO:0043113	receptor clustering; IBA:GO_Central.
# GO_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity; IBA:GO_Central.
# GO_process	GO:0097120	receptor localization to synapse; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005615	extracellular space
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016301	kinase activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0061024	membrane organization
# Gene3D	2.30.42.10	-; 3.
# Gene3D	3.40.50.300	-; 2.
# Genevisible	Q92796	HS
# HGNC	HGNC:2902	DLG3
# INTERACTION	DLG3_HUMAN	P62136 PPP1CA; NbExp=2; IntAct=EBI-80440, EBI-357253; 
# IntAct	Q92796	25
# InterPro	IPR001452	SH3_domain
# InterPro	IPR001478	PDZ
# InterPro	IPR008144	Guanylate_kin-like_dom
# InterPro	IPR008145	GK/Ca_channel_bsu
# InterPro	IPR016313	DLG1
# InterPro	IPR019583	PDZ_assoc
# InterPro	IPR019590	DLG1_PEST_dom
# InterPro	IPR020590	Guanylate_kinase_CS
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Disease	H00480	[Congenital disorder; Mental retardation] Non-syndromic X-linked mental retardation
# KEGG_Pathway	ko04390	Hippo signaling pathway
# MIM	300189	gene
# MIM	300850	phenotype
# Organism	DLG3_HUMAN	Homo sapiens (Human)
# Orphanet	777	X-linked non-syndromic intellectual disability
# PDB	1UM7	NMR; -; A=382-475
# PDB	2FE5	X-ray; 1.10 A; A=223-314
# PDB	2I1N	X-ray; 1.85 A; A/B=126-222
# PIRSF	PIRSF001741	MAGUK_DLGH
# PROSITE	PS00856	GUANYLATE_KINASE_1
# PROSITE	PS50002	SH3
# PROSITE	PS50052	GUANYLATE_KINASE_2
# PROSITE	PS50106	PDZ; 3
# Pfam	PF00018	SH3_1
# Pfam	PF00595	PDZ; 3
# Pfam	PF00625	Guanylate_kin
# Pfam	PF10600	PDZ_assoc
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-447038	NrCAM interactions
# Reactome	R-HSA-451308	Activation of Ca-permeable Kainate Receptor
# Reactome	R-HSA-6794361	Interactions of neurexins and neuroligins at synapses
# Reactome	R-HSA-8849932	SALM protein interactions at the synapses
# RecName	DLG3_HUMAN	Disks large homolog 3
# RefSeq	NP_001159750	NM_001166278.1. [Q92796-3]
# RefSeq	NP_065781	NM_020730.2. [Q92796-2]
# RefSeq	NP_066943	NM_021120.3. [Q92796-1]
# RefSeq	XP_005262305	XM_005262248.3. [Q92796-3]
# RefSeq	XP_016884815	XM_017029326.1. [Q92796-3]
# SEQUENCE CAUTION	Sequence=BAA86546.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the MAGUK family. {ECO	0000305}. 
# SIMILARITY	Contains 1 SH3 domain. {ECO:0000255|PROSITE- ProRule	PRU00192}. 
# SIMILARITY	Contains 1 guanylate kinase-like domain. {ECO:0000255|PROSITE-ProRule	PRU00100}. 
# SIMILARITY	Contains 3 PDZ (DHR) domains. {ECO:0000255|PROSITE- ProRule	PRU00143}. 
# SMART	SM00072	GuKc
# SMART	SM00228	PDZ; 3
# SMART	SM00326	SH3
# SMART	SM01277	MAGUK_N_PEST
# SUBUNIT	DLG3_HUMAN	Interacts through its PDZ domains with NETO1, GRIN2B and SYNGAP1. Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3 and DLGAP4. Interacts with FLTP/C1orf192 (By similarity). Interacts through its PDZ domains with APC. Interacts through its first two PDZ domains with ERBB4. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4. {ECO 0000250|UniProtKB P70175, ECO 0000269|PubMed 10725395, ECO 0000269|PubMed 16630835, ECO 0000269|PubMed 19118189, ECO 0000269|PubMed 9188857, ECO 0000269|PubMed 9278515}. 
# SUPFAM	SSF50044	SSF50044; 2
# SUPFAM	SSF50156	SSF50156; 3
# SUPFAM	SSF52540	SSF52540
# UCSC	uc004dyi	human. [Q92796-1]
# eggNOG	COG0194	LUCA
# eggNOG	KOG0708	Eukaryota
BLAST	swissprot:DLG3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:DLG3_HUMAN
BioCyc	ZFISH:ENSG00000082458-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000082458-MONOMER
COXPRESdb	1741	http://coxpresdb.jp/data/gene/1741.shtml
CleanEx	HS_DLG3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_DLG3
DOI	10.1016/j.neuron.2006.04.005	http://dx.doi.org/10.1016/j.neuron.2006.04.005
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.onc.1201087	http://dx.doi.org/10.1038/sj.onc.1201087
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1073/pnas.97.7.3596	http://dx.doi.org/10.1073/pnas.97.7.3596
DOI	10.1086/422703	http://dx.doi.org/10.1086/422703
DOI	10.1093/dnares/6.5.337	http://dx.doi.org/10.1093/dnares/6.5.337
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1126/science.277.5331.1511	http://dx.doi.org/10.1126/science.277.5331.1511
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1523/JNEUROSCI.3112-08.2008	http://dx.doi.org/10.1523/JNEUROSCI.3112-08.2008
EMBL	AB033058	http://www.ebi.ac.uk/ena/data/view/AB033058
EMBL	AK303377	http://www.ebi.ac.uk/ena/data/view/AK303377
EMBL	AK304020	http://www.ebi.ac.uk/ena/data/view/AK304020
EMBL	AK316518	http://www.ebi.ac.uk/ena/data/view/AK316518
EMBL	AL139109	http://www.ebi.ac.uk/ena/data/view/AL139109
EMBL	AL139398	http://www.ebi.ac.uk/ena/data/view/AL139398
EMBL	AL139398	http://www.ebi.ac.uk/ena/data/view/AL139398
EMBL	BC093864	http://www.ebi.ac.uk/ena/data/view/BC093864
EMBL	BC093866	http://www.ebi.ac.uk/ena/data/view/BC093866
EMBL	CH471132	http://www.ebi.ac.uk/ena/data/view/CH471132
EMBL	CH471132	http://www.ebi.ac.uk/ena/data/view/CH471132
EMBL	CH471132	http://www.ebi.ac.uk/ena/data/view/CH471132
EMBL	CH471132	http://www.ebi.ac.uk/ena/data/view/CH471132
EMBL	U49089	http://www.ebi.ac.uk/ena/data/view/U49089
Ensembl	ENST00000374355	http://www.ensembl.org/id/ENST00000374355
Ensembl	ENST00000374360	http://www.ensembl.org/id/ENST00000374360
Ensembl	ENST00000542398	http://www.ensembl.org/id/ENST00000542398
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005615
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005923	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005923
GO_component	GO:0014069	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014069
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0030426	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030426
GO_component	GO:0032281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032281
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0043198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043198
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0004385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004385
GO_function	GO:0015276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015276
GO_function	GO:0019900	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019900
GO_function	GO:0019902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019902
GO_function	GO:0035255	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035255
GO_process	GO:0001736	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001736
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007399	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007399
GO_process	GO:0008285	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008285
GO_process	GO:0010923	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010923
GO_process	GO:0043113	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043113
GO_process	GO:0045197	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045197
GO_process	GO:0097120	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097120
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005615	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005615
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
Gene3D	2.30.42.10	http://www.cathdb.info/version/latest/superfamily/2.30.42.10
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	DLG3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=DLG3
GeneID	1741	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1741
GeneTree	ENSGT00760000118866	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118866
H-InvDB	HIX0016853	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0016853
HGNC	HGNC:2902	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2902
HOGENOM	HOG000232102	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000232102&db=HOGENOM6
HOVERGEN	HBG107814	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG107814&db=HOVERGEN
HPA	HPA001733	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA001733
InParanoid	Q92796	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q92796
IntAct	Q92796	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q92796*
InterPro	IPR001452	http://www.ebi.ac.uk/interpro/entry/IPR001452
InterPro	IPR001478	http://www.ebi.ac.uk/interpro/entry/IPR001478
InterPro	IPR008144	http://www.ebi.ac.uk/interpro/entry/IPR008144
InterPro	IPR008145	http://www.ebi.ac.uk/interpro/entry/IPR008145
InterPro	IPR016313	http://www.ebi.ac.uk/interpro/entry/IPR016313
InterPro	IPR019583	http://www.ebi.ac.uk/interpro/entry/IPR019583
InterPro	IPR019590	http://www.ebi.ac.uk/interpro/entry/IPR019590
InterPro	IPR020590	http://www.ebi.ac.uk/interpro/entry/IPR020590
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	1741	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1741
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Disease	H00480	http://www.genome.jp/dbget-bin/www_bget?H00480
KEGG_Gene	hsa:1741	http://www.genome.jp/dbget-bin/www_bget?hsa:1741
KEGG_Orthology	KO:K12075	http://www.genome.jp/dbget-bin/www_bget?KO:K12075
KEGG_Pathway	ko04390	http://www.genome.jp/kegg-bin/show_pathway?ko04390
MIM	300189	http://www.ncbi.nlm.nih.gov/omim/300189
MIM	300850	http://www.ncbi.nlm.nih.gov/omim/300850
MINT	MINT-109320	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-109320
OMA	ASQRWAW	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ASQRWAW
Orphanet	777	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=777
PDB	1UM7	http://www.ebi.ac.uk/pdbe-srv/view/entry/1UM7
PDB	2FE5	http://www.ebi.ac.uk/pdbe-srv/view/entry/2FE5
PDB	2I1N	http://www.ebi.ac.uk/pdbe-srv/view/entry/2I1N
PDBsum	1UM7	http://www.ebi.ac.uk/pdbsum/1UM7
PDBsum	2FE5	http://www.ebi.ac.uk/pdbsum/2FE5
PDBsum	2I1N	http://www.ebi.ac.uk/pdbsum/2I1N
PROSITE	PS00856	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00856
PROSITE	PS50002	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50002
PROSITE	PS50052	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50052
PROSITE	PS50106	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50106
PSORT	swissprot:DLG3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:DLG3_HUMAN
PSORT-B	swissprot:DLG3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:DLG3_HUMAN
PSORT2	swissprot:DLG3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:DLG3_HUMAN
Pfam	PF00018	http://pfam.xfam.org/family/PF00018
Pfam	PF00595	http://pfam.xfam.org/family/PF00595
Pfam	PF00625	http://pfam.xfam.org/family/PF00625
Pfam	PF10600	http://pfam.xfam.org/family/PF10600
PharmGKB	PA164741439	http://www.pharmgkb.org/do/serve?objId=PA164741439&objCls=Gene
Phobius	swissprot:DLG3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:DLG3_HUMAN
PhylomeDB	Q92796	http://phylomedb.org/?seqid=Q92796
ProteinModelPortal	Q92796	http://www.proteinmodelportal.org/query/uniprot/Q92796
PubMed	10574462	http://www.ncbi.nlm.nih.gov/pubmed/10574462
PubMed	10725395	http://www.ncbi.nlm.nih.gov/pubmed/10725395
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15185169	http://www.ncbi.nlm.nih.gov/pubmed/15185169
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	16630835	http://www.ncbi.nlm.nih.gov/pubmed/16630835
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	19118189	http://www.ncbi.nlm.nih.gov/pubmed/19118189
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	9188857	http://www.ncbi.nlm.nih.gov/pubmed/9188857
PubMed	9278515	http://www.ncbi.nlm.nih.gov/pubmed/9278515
Reactome	R-HSA-447038	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-447038
Reactome	R-HSA-451308	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-451308
Reactome	R-HSA-6794361	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6794361
Reactome	R-HSA-8849932	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8849932
RefSeq	NP_001159750	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001159750
RefSeq	NP_065781	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_065781
RefSeq	NP_066943	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_066943
RefSeq	XP_005262305	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005262305
RefSeq	XP_016884815	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016884815
SMART	SM00072	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00072
SMART	SM00228	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00228
SMART	SM00326	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00326
SMART	SM01277	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01277
SMR	Q92796	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q92796
STRING	9606.ENSP00000363480	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000363480&targetmode=cogs
SUPFAM	SSF50044	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50044
SUPFAM	SSF50156	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50156
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
UCSC	uc004dyi	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004dyi&org=rat
UniGene	Hs.721586	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.721586
UniProtKB	DLG3_HUMAN	http://www.uniprot.org/uniprot/DLG3_HUMAN
UniProtKB-AC	Q92796	http://www.uniprot.org/uniprot/Q92796
charge	swissprot:DLG3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:DLG3_HUMAN
eggNOG	COG0194	http://eggnogapi.embl.de/nog_data/html/tree/COG0194
eggNOG	KOG0708	http://eggnogapi.embl.de/nog_data/html/tree/KOG0708
epestfind	swissprot:DLG3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:DLG3_HUMAN
garnier	swissprot:DLG3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:DLG3_HUMAN
helixturnhelix	swissprot:DLG3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:DLG3_HUMAN
hmoment	swissprot:DLG3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:DLG3_HUMAN
iep	swissprot:DLG3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:DLG3_HUMAN
inforesidue	swissprot:DLG3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:DLG3_HUMAN
neXtProt	NX_Q92796	http://www.nextprot.org/db/entry/NX_Q92796
octanol	swissprot:DLG3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:DLG3_HUMAN
pepcoil	swissprot:DLG3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:DLG3_HUMAN
pepdigest	swissprot:DLG3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:DLG3_HUMAN
pepinfo	swissprot:DLG3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:DLG3_HUMAN
pepnet	swissprot:DLG3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:DLG3_HUMAN
pepstats	swissprot:DLG3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:DLG3_HUMAN
pepwheel	swissprot:DLG3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:DLG3_HUMAN
pepwindow	swissprot:DLG3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:DLG3_HUMAN
sigcleave	swissprot:DLG3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:DLG3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCJ11_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14654-1; Sequence=Displayed; Name=2; IsoId=Q14654-2; Sequence=VSP_045270; 
# AltName	KCJ11_HUMAN	IKATP
# AltName	KCJ11_HUMAN	Inward rectifier K(+) channel Kir6.2
# AltName	KCJ11_HUMAN	Potassium channel, inwardly rectifying subfamily J member 11
# BioGrid	109969	12
# CCDS	CCDS31436	-. [Q14654-1]
# CCDS	CCDS53606	-. [Q14654-2]
# DISEASE	KCJ11_HUMAN	Diabetes mellitus, permanent neonatal (PNDM) [MIM 606176]  A rare form of diabetes distinct from childhood- onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy. {ECO 0000269|PubMed 15115830, ECO 0000269|PubMed 15292329, ECO 0000269|PubMed 15448106, ECO 0000269|PubMed 15448107, ECO 0000269|PubMed 15580558, ECO 0000269|PubMed 16609879, ECO 0000269|PubMed 16731833, ECO 0000269|PubMed 17213273, ECO 0000269|PubMed 17652641, ECO 0000269|PubMed 20022885}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	KCJ11_HUMAN	Familial hyperinsulinemic hypoglycemia 2 (HHF2) [MIM 601820]  Most common cause of persistent hypoglycemia in infancy. Unless early and aggressive intervention is undertaken, brain damage from recurrent episodes of hypoglycemia may occur. {ECO 0000269|PubMed 10204114, ECO 0000269|PubMed 12364426, ECO 0000269|PubMed 15562009, ECO 0000269|PubMed 15579781, ECO 0000269|PubMed 15807877, ECO 0000269|PubMed 15998776, ECO 0000269|PubMed 16332676, ECO 0000269|PubMed 16357843, ECO 0000269|PubMed 18596924, ECO 0000269|PubMed 19357197, ECO 0000269|PubMed 7847376, ECO 0000269|PubMed 8923010}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	KCJ11_HUMAN	Maturity-onset diabetes of the young 13 (MODY13) [MIM 616329]  A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. {ECO 0000269|PubMed 22701567}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	KCJ11_HUMAN	Note=Defects in KCNJ11 may contribute to non-insulin- dependent diabetes mellitus (NIDDM), also known as diabetes mellitus type 2. 
# DISEASE	KCJ11_HUMAN	Transient neonatal diabetes mellitus 3 (TNDM3) [MIM 610582]  Neonatal diabetes mellitus, defined as insulin- requiring hyperglycemia within the first month of life, is a rare entity. In about half of the neonates, diabetes is transient and resolves at a median age of 3 months, whereas the rest have a permanent form of diabetes. In a significant number of patients with transient neonatal diabetes mellitus, diabetes type 2 appears later in life. The onset and severity of TNDM3 is variable with childhood-onset diabetes, gestational diabetes or adult-onset diabetes described. {ECO 0000269|PubMed 15718250, ECO 0000269|PubMed 15784703}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00222	Glimepiride
# DrugBank	DB00308	Ibutilide
# DrugBank	DB00661	Verapamil
# DrugBank	DB00922	Levosimendan
# DrugBank	DB01016	Glyburide
# DrugBank	DB01119	Diazoxide
# DrugBank	DB01154	Thiamylal
# DrugBank	DB01392	Yohimbine
# Ensembl	ENST00000339994	ENSP00000345708; ENSG00000187486
# Ensembl	ENST00000528731	ENSP00000434755; ENSG00000187486
# ExpressionAtlas	Q14654	baseline and differential
# FUNCTION	KCJ11_HUMAN	This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. {ECO 0000250, ECO 0000269|PubMed 17855752, ECO 0000269|PubMed 9831708}. 
# GO_component	GO:0005635	nuclear envelope; IEA:Ensembl.
# GO_component	GO:0005739	mitochondrion; IEA:Ensembl.
# GO_component	GO:0005768	endosome; IEA:Ensembl.
# GO_component	GO:0005783	endoplasmic reticulum; IEA:Ensembl.
# GO_component	GO:0005829	cytosol; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IDA:BHF-UCL.
# GO_component	GO:0008282	ATP-sensitive potassium channel complex; IDA:BHF-UCL.
# GO_component	GO:0014704	intercalated disc; IEA:Ensembl.
# GO_component	GO:0030315	T-tubule; ISS:BHF-UCL.
# GO_component	GO:0030673	axolemma; IEA:Ensembl.
# GO_component	GO:0043025	neuronal cell body; IEA:Ensembl.
# GO_component	GO:0043209	myelin sheath; IEA:Ensembl.
# GO_component	GO:0070852	cell body fiber; IEA:Ensembl.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IDA:BHF-UCL.
# GO_function	GO:0005524	ATP binding; ISS:BHF-UCL.
# GO_function	GO:0015272	ATP-activated inward rectifier potassium channel activity; ISS:BHF-UCL.
# GO_function	GO:0030506	ankyrin binding; IPI:BHF-UCL.
# GO_function	GO:0030955	potassium ion binding; TAS:BHF-UCL.
# GO_function	GO:0044325	ion channel binding; IPI:BHF-UCL.
# GO_process	GO:0002931	response to ischemia; IEA:Ensembl.
# GO_process	GO:0006006	glucose metabolic process; IMP:BHF-UCL.
# GO_process	GO:0010107	potassium ion import; ISS:BHF-UCL.
# GO_process	GO:0032355	response to estradiol; IEA:Ensembl.
# GO_process	GO:0033198	response to ATP; IDA:BHF-UCL.
# GO_process	GO:0033574	response to testosterone; IEA:Ensembl.
# GO_process	GO:0042391	regulation of membrane potential; IDA:BHF-UCL.
# GO_process	GO:0042493	response to drug; IMP:BHF-UCL.
# GO_process	GO:0046676	negative regulation of insulin secretion; IMP:BHF-UCL.
# GO_process	GO:0050796	regulation of insulin secretion; IMP:BHF-UCL.
# GO_process	GO:0050877	neurological system process; IMP:BHF-UCL.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GO_process	GO:0071316	cellular response to nicotine; IEA:Ensembl.
# GO_process	GO:0071333	cellular response to glucose stimulus; IEA:Ensembl.
# GO_process	GO:0071356	cellular response to tumor necrosis factor; IEA:Ensembl.
# GO_process	GO:0071805	potassium ion transmembrane transport; IDA:BHF-UCL.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GO_process	GO:2001259	positive regulation of cation channel activity; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005635	nuclear envelope
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008092	cytoskeletal protein binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0005975	carbohydrate metabolic process
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.40.1400	-; 1.
# Genevisible	Q14654	HS
# HGNC	HGNC:6257	KCNJ11
# IntAct	Q14654	4
# InterPro	IPR003279	K_chnl_inward-rec_Kir6.2
# InterPro	IPR013518	K_chnl_inward-rec_Kir_cyto
# InterPro	IPR014756	Ig_E-set
# InterPro	IPR016449	K_chnl_inward-rec_Kir
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00409	[Metabolic disease; Endocrine disease] Type II diabetes mellitus
# KEGG_Disease	H00512	[Metabolic disease; Endocrine disease] Permanent neonatal diabetes mellitus (PNDM)
# KEGG_Disease	H00513	[Metabolic disease; Endocrine disease] Transient neonatal diabetes mellitus (TNDM)
# KEGG_Disease	H01267	[Inherited metabolic disease] Familial hyperinsulinemic hypoglycemia (HHF)
# KEGG_Pathway	ko04930	Type II diabetes mellitus
# MIM	600937	gene
# MIM	601820	phenotype
# MIM	606176	phenotype
# MIM	610582	phenotype
# MIM	616329	phenotype
# Organism	KCJ11_HUMAN	Homo sapiens (Human)
# Orphanet	276580	Autosomal dominant hyperinsulinism due to Kir6.2 deficiency
# Orphanet	276603	Diazoxide-resistant focal hyperinsulinism due to Kir6.2 deficiency
# Orphanet	552	MODY
# Orphanet	79134	DEND syndrome
# Orphanet	79644	Autosomal recessive hyperinsulinism due to Kir6.2 deficiency
# Orphanet	99885	Permanent neonatal diabetes mellitus
# Orphanet	99886	Transient neonatal diabetes mellitus
# Orphanet	99989	Intermediate DEND syndrome
# PANTHER	PTHR11767	PTHR11767
# PANTHER	PTHR11767:SF44	PTHR11767:SF44
# PIR	A57616	A57616
# PIRSF	PIRSF005465	GIRK_kir
# PRINTS	PR01320	KIRCHANNEL
# PRINTS	PR01332	KIR62CHANNEL
# PTM	KCJ11_HUMAN	Phosphorylation by MAPK1 results in changes in channel gating that destabilize the closed states and reduce the ATP sensitivity. {ECO 0000269|PubMed 18280666}. 
# Pfam	PF01007	IRK
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-1296025	ATP sensitive Potassium channels
# Reactome	R-HSA-382556	ABC-family proteins mediated transport
# Reactome	R-HSA-422356	Regulation of insulin secretion
# Reactome	R-HSA-5578775	Ion homeostasis
# Reactome	R-HSA-5683177	Defective ABCC8 can cause hypoglycemias and hyperglycemias
# RecName	KCJ11_HUMAN	ATP-sensitive inward rectifier potassium channel 11
# RefSeq	NP_001159762	NM_001166290.1
# SEQUENCE CAUTION	Sequence=AAH40617.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	KCJ11_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	KCJ11_HUMAN	Interacts with ABCC8/SUR. Interacts with ABCC9/SUR2. {ECO 0000269|PubMed 17855752, ECO 0000269|PubMed 9831708}. 
# SUPFAM	SSF81296	SSF81296
# UCSC	uc001mna	human. [Q14654-1]
# eggNOG	ENOG410XQ62	LUCA
# eggNOG	KOG3827	Eukaryota
BLAST	swissprot:KCJ11_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCJ11_HUMAN
BioCyc	ZFISH:G66-33006-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33006-MONOMER
COXPRESdb	3767	http://coxpresdb.jp/data/gene/3767.shtml
CleanEx	HS_KCNJ11	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNJ11
DIP	DIP-58643N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-58643N
DOI	10.1002/(SICI)1098-1004(1999)13:5<351::AID-HUMU3>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1999)13:5<351::AID-HUMU3>3.0.CO
DOI	10.1002/humu.20124	http://dx.doi.org/10.1002/humu.20124
DOI	10.1002/humu.9401	http://dx.doi.org/10.1002/humu.9401
DOI	10.1007/BF02658512	http://dx.doi.org/10.1007/BF02658512
DOI	10.1007/s00125-006-0246-z	http://dx.doi.org/10.1007/s00125-006-0246-z
DOI	10.1016/S0006-3495(03)74847-4	http://dx.doi.org/10.1016/S0006-3495(03)74847-4
DOI	10.1016/j.neuroscience.2008.01.003	http://dx.doi.org/10.1016/j.neuroscience.2008.01.003
DOI	10.1038/10297	http://dx.doi.org/10.1038/10297
DOI	10.1038/modpathol.3800497	http://dx.doi.org/10.1038/modpathol.3800497
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1056/NEJMoa032922	http://dx.doi.org/10.1056/NEJMoa032922
DOI	10.1073/pnas.0404756101	http://dx.doi.org/10.1073/pnas.0404756101
DOI	10.1074/jbc.M511875200	http://dx.doi.org/10.1074/jbc.M511875200
DOI	10.1093/hmg/5.11.1809	http://dx.doi.org/10.1093/hmg/5.11.1809
DOI	10.1093/hmg/ddi086	http://dx.doi.org/10.1093/hmg/ddi086
DOI	10.1093/hmg/ddp179	http://dx.doi.org/10.1093/hmg/ddp179
DOI	10.1093/hmg/ddp554	http://dx.doi.org/10.1093/hmg/ddp554
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1365-2265.2005.02242.x	http://dx.doi.org/10.1111/j.1365-2265.2005.02242.x
DOI	10.1113/jphysiol.2007.143149	http://dx.doi.org/10.1113/jphysiol.2007.143149
DOI	10.1126/science.270.5239.1166	http://dx.doi.org/10.1126/science.270.5239.1166
DOI	10.1161/01.RES.83.11.1132	http://dx.doi.org/10.1161/01.RES.83.11.1132
DOI	10.1172/JCI35414	http://dx.doi.org/10.1172/JCI35414
DOI	10.1210/edrv.20.2.0361	http://dx.doi.org/10.1210/edrv.20.2.0361
DOI	10.1210/jc.2002-020378	http://dx.doi.org/10.1210/jc.2002-020378
DOI	10.1210/jc.2004-0568	http://dx.doi.org/10.1210/jc.2004-0568
DOI	10.1210/jc.2004-1233	http://dx.doi.org/10.1210/jc.2004-1233
DOI	10.1210/jc.2004-1604	http://dx.doi.org/10.1210/jc.2004-1604
DOI	10.1210/jc.2005-0096	http://dx.doi.org/10.1210/jc.2005-0096
DOI	10.1210/jc.2005-0202	http://dx.doi.org/10.1210/jc.2005-0202
DOI	10.1210/jc.2006-2490	http://dx.doi.org/10.1210/jc.2006-2490
DOI	10.1212/01.wnl.0000268488.51776.53	http://dx.doi.org/10.1212/01.wnl.0000268488.51776.53
DOI	10.1371/journal.pone.0037423	http://dx.doi.org/10.1371/journal.pone.0037423
DOI	10.2337/db05-1640	http://dx.doi.org/10.2337/db05-1640
DOI	10.2337/diab.46.3.502	http://dx.doi.org/10.2337/diab.46.3.502
DOI	10.2337/diabetes.53.10.2713	http://dx.doi.org/10.2337/diabetes.53.10.2713
DOI	10.2337/diabetes.53.10.2719	http://dx.doi.org/10.2337/diabetes.53.10.2719
DrugBank	DB00222	http://www.drugbank.ca/drugs/DB00222
DrugBank	DB00308	http://www.drugbank.ca/drugs/DB00308
DrugBank	DB00661	http://www.drugbank.ca/drugs/DB00661
DrugBank	DB00922	http://www.drugbank.ca/drugs/DB00922
DrugBank	DB01016	http://www.drugbank.ca/drugs/DB01016
DrugBank	DB01119	http://www.drugbank.ca/drugs/DB01119
DrugBank	DB01154	http://www.drugbank.ca/drugs/DB01154
DrugBank	DB01392	http://www.drugbank.ca/drugs/DB01392
EMBL	AC124798	http://www.ebi.ac.uk/ena/data/view/AC124798
EMBL	AK301550	http://www.ebi.ac.uk/ena/data/view/AK301550
EMBL	BC040617	http://www.ebi.ac.uk/ena/data/view/BC040617
EMBL	BC064497	http://www.ebi.ac.uk/ena/data/view/BC064497
EMBL	BC112358	http://www.ebi.ac.uk/ena/data/view/BC112358
EMBL	D50582	http://www.ebi.ac.uk/ena/data/view/D50582
Ensembl	ENST00000339994	http://www.ensembl.org/id/ENST00000339994
Ensembl	ENST00000528731	http://www.ensembl.org/id/ENST00000528731
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0008282	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008282
GO_component	GO:0014704	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014704
GO_component	GO:0030315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030315
GO_component	GO:0030673	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030673
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0043209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043209
GO_component	GO:0070852	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070852
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0015272	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015272
GO_function	GO:0030506	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030506
GO_function	GO:0030955	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030955
GO_function	GO:0044325	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044325
GO_process	GO:0002931	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002931
GO_process	GO:0006006	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006006
GO_process	GO:0010107	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010107
GO_process	GO:0032355	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032355
GO_process	GO:0033198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033198
GO_process	GO:0033574	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033574
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0046676	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046676
GO_process	GO:0050796	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050796
GO_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GO_process	GO:0071316	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071316
GO_process	GO:0071333	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071333
GO_process	GO:0071356	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071356
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GO_process	GO:2001259	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001259
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005635	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005635
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.40.1400	http://www.cathdb.info/version/latest/superfamily/2.60.40.1400
GeneCards	KCNJ11	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNJ11
GeneID	3767	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3767
H-InvDB	HIX0035982	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0035982
HGNC	HGNC:6257	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6257
HOGENOM	HOG000237325	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237325&db=HOGENOM6
HOVERGEN	HBG006178	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006178&db=HOVERGEN
HPA	HPA048891	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA048891
InParanoid	Q14654	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q14654
IntAct	Q14654	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q14654*
InterPro	IPR003279	http://www.ebi.ac.uk/interpro/entry/IPR003279
InterPro	IPR013518	http://www.ebi.ac.uk/interpro/entry/IPR013518
InterPro	IPR014756	http://www.ebi.ac.uk/interpro/entry/IPR014756
InterPro	IPR016449	http://www.ebi.ac.uk/interpro/entry/IPR016449
Jabion	3767	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3767
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00409	http://www.genome.jp/dbget-bin/www_bget?H00409
KEGG_Disease	H00512	http://www.genome.jp/dbget-bin/www_bget?H00512
KEGG_Disease	H00513	http://www.genome.jp/dbget-bin/www_bget?H00513
KEGG_Disease	H01267	http://www.genome.jp/dbget-bin/www_bget?H01267
KEGG_Gene	hsa:3767	http://www.genome.jp/dbget-bin/www_bget?hsa:3767
KEGG_Orthology	KO:K05004	http://www.genome.jp/dbget-bin/www_bget?KO:K05004
KEGG_Pathway	ko04930	http://www.genome.jp/kegg-bin/show_pathway?ko04930
MIM	600937	http://www.ncbi.nlm.nih.gov/omim/600937
MIM	601820	http://www.ncbi.nlm.nih.gov/omim/601820
MIM	606176	http://www.ncbi.nlm.nih.gov/omim/606176
MIM	610582	http://www.ncbi.nlm.nih.gov/omim/610582
MIM	616329	http://www.ncbi.nlm.nih.gov/omim/616329
Orphanet	276580	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=276580
Orphanet	276603	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=276603
Orphanet	552	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=552
Orphanet	79134	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=79134
Orphanet	79644	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=79644
Orphanet	99885	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=99885
Orphanet	99886	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=99886
Orphanet	99989	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=99989
OrthoDB	EOG091G08HC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08HC
PANTHER	PTHR11767	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11767
PANTHER	PTHR11767:SF44	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11767:SF44
PRINTS	PR01320	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01320
PRINTS	PR01332	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01332
PSORT	swissprot:KCJ11_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCJ11_HUMAN
PSORT-B	swissprot:KCJ11_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCJ11_HUMAN
PSORT2	swissprot:KCJ11_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCJ11_HUMAN
Pfam	PF01007	http://pfam.xfam.org/family/PF01007
PharmGKB	PA217	http://www.pharmgkb.org/do/serve?objId=PA217&objCls=Gene
Phobius	swissprot:KCJ11_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCJ11_HUMAN
PhylomeDB	Q14654	http://phylomedb.org/?seqid=Q14654
ProteinModelPortal	Q14654	http://www.proteinmodelportal.org/query/uniprot/Q14654
PubMed	10204114	http://www.ncbi.nlm.nih.gov/pubmed/10204114
PubMed	10338089	http://www.ncbi.nlm.nih.gov/pubmed/10338089
PubMed	10391210	http://www.ncbi.nlm.nih.gov/pubmed/10391210
PubMed	12364426	http://www.ncbi.nlm.nih.gov/pubmed/12364426
PubMed	12524280	http://www.ncbi.nlm.nih.gov/pubmed/12524280
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15115830	http://www.ncbi.nlm.nih.gov/pubmed/15115830
PubMed	15292329	http://www.ncbi.nlm.nih.gov/pubmed/15292329
PubMed	15448106	http://www.ncbi.nlm.nih.gov/pubmed/15448106
PubMed	15448107	http://www.ncbi.nlm.nih.gov/pubmed/15448107
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15562009	http://www.ncbi.nlm.nih.gov/pubmed/15562009
PubMed	15579781	http://www.ncbi.nlm.nih.gov/pubmed/15579781
PubMed	15580558	http://www.ncbi.nlm.nih.gov/pubmed/15580558
PubMed	15583126	http://www.ncbi.nlm.nih.gov/pubmed/15583126
PubMed	15718250	http://www.ncbi.nlm.nih.gov/pubmed/15718250
PubMed	15784703	http://www.ncbi.nlm.nih.gov/pubmed/15784703
PubMed	15807877	http://www.ncbi.nlm.nih.gov/pubmed/15807877
PubMed	15998776	http://www.ncbi.nlm.nih.gov/pubmed/15998776
PubMed	16332676	http://www.ncbi.nlm.nih.gov/pubmed/16332676
PubMed	16357843	http://www.ncbi.nlm.nih.gov/pubmed/16357843
PubMed	16429405	http://www.ncbi.nlm.nih.gov/pubmed/16429405
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	16609879	http://www.ncbi.nlm.nih.gov/pubmed/16609879
PubMed	16731833	http://www.ncbi.nlm.nih.gov/pubmed/16731833
PubMed	17213273	http://www.ncbi.nlm.nih.gov/pubmed/17213273
PubMed	17652641	http://www.ncbi.nlm.nih.gov/pubmed/17652641
PubMed	17855752	http://www.ncbi.nlm.nih.gov/pubmed/17855752
PubMed	18280666	http://www.ncbi.nlm.nih.gov/pubmed/18280666
PubMed	18596924	http://www.ncbi.nlm.nih.gov/pubmed/18596924
PubMed	19357197	http://www.ncbi.nlm.nih.gov/pubmed/19357197
PubMed	20022885	http://www.ncbi.nlm.nih.gov/pubmed/20022885
PubMed	22701567	http://www.ncbi.nlm.nih.gov/pubmed/22701567
PubMed	7502040	http://www.ncbi.nlm.nih.gov/pubmed/7502040
PubMed	7847376	http://www.ncbi.nlm.nih.gov/pubmed/7847376
PubMed	8897013	http://www.ncbi.nlm.nih.gov/pubmed/8897013
PubMed	8923010	http://www.ncbi.nlm.nih.gov/pubmed/8923010
PubMed	9032109	http://www.ncbi.nlm.nih.gov/pubmed/9032109
PubMed	9831708	http://www.ncbi.nlm.nih.gov/pubmed/9831708
Reactome	R-HSA-1296025	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296025
Reactome	R-HSA-382556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-382556
Reactome	R-HSA-422356	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-422356
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
Reactome	R-HSA-5683177	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5683177
RefSeq	NP_001159762	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001159762
SMR	Q14654	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q14654
STRING	9606.ENSP00000345708	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000345708&targetmode=cogs
SUPFAM	SSF81296	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81296
UCSC	uc001mna	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001mna&org=rat
UniGene	Hs.248141	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.248141
UniProtKB	KCJ11_HUMAN	http://www.uniprot.org/uniprot/KCJ11_HUMAN
UniProtKB-AC	Q14654	http://www.uniprot.org/uniprot/Q14654
charge	swissprot:KCJ11_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCJ11_HUMAN
eggNOG	ENOG410XQ62	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ62
eggNOG	KOG3827	http://eggnogapi.embl.de/nog_data/html/tree/KOG3827
epestfind	swissprot:KCJ11_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCJ11_HUMAN
garnier	swissprot:KCJ11_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCJ11_HUMAN
helixturnhelix	swissprot:KCJ11_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCJ11_HUMAN
hmoment	swissprot:KCJ11_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCJ11_HUMAN
iep	swissprot:KCJ11_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCJ11_HUMAN
inforesidue	swissprot:KCJ11_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCJ11_HUMAN
neXtProt	NX_Q14654	http://www.nextprot.org/db/entry/NX_Q14654
octanol	swissprot:KCJ11_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCJ11_HUMAN
pepcoil	swissprot:KCJ11_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCJ11_HUMAN
pepdigest	swissprot:KCJ11_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCJ11_HUMAN
pepinfo	swissprot:KCJ11_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCJ11_HUMAN
pepnet	swissprot:KCJ11_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCJ11_HUMAN
pepstats	swissprot:KCJ11_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCJ11_HUMAN
pepwheel	swissprot:KCJ11_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCJ11_HUMAN
pepwindow	swissprot:KCJ11_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCJ11_HUMAN
sigcleave	swissprot:KCJ11_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCJ11_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CLCA4_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14CN2-1; Sequence=Displayed; Name=2; IsoId=Q14CN2-2; Sequence=VSP_056117, VSP_056118, VSP_056119; Note=No experimental confirmation available.; 
# AltName	CLCA4_HUMAN	Calcium-activated chloride channel family member 4
# AltName	CLCA4_HUMAN	Calcium-activated chloride channel protein 2
# AltName	CLCA4_HUMAN	Chloride channel accessory 4
# AltName	CLCA4_HUMAN	Chloride channel accessory 4
# CCDS	CCDS41355	-. [Q14CN2-1]
# DOMAIN	CLCA4_HUMAN	The metalloprotease region is responsible for autoproteolytic processing. It can also cross-cleave other CLCA Substrates. {ECO 0000250|UniProtKB A8K7I4}. 
# Ensembl	ENST00000370563	ENSP00000359594; ENSG00000016602. [Q14CN2-1]
# FUNCTION	CLCA4_HUMAN	May be involved in mediating calcium-activated chloride conductance. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016324	apical plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0004222	metalloendopeptidase activity; TAS:Reactome.
# GO_function	GO:0005229	intracellular calcium activated chloride channel activity; IEA:InterPro.
# GO_function	GO:0005254	chloride channel activity; TAS:ProtInc.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0008233	peptidase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.410	-; 1.
# Genevisible	Q14CN2	HS
# HGNC	HGNC:2018	CLCA4
# INDUCTION	Down-regulated in oral tongue squamous cell carcinomas. {ECO:0000269|PubMed	18254958}. 
# InterPro	IPR002035	VWF_A
# InterPro	IPR004727	CLCA_chordata
# InterPro	IPR013642	CLCA
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04740	Olfactory transduction
# KEGG_Pathway	ko04972	Pancreatic secretion
# MIM	616857	gene
# Organism	CLCA4_HUMAN	Homo sapiens (Human)
# Orphanet	586	Cystic fibrosis
# PROSITE	PS50234	VWFA
# PTM	CLCA4_HUMAN	The translation product is autoproteolytically cleaved by the metalloprotease domain in the endoplasmic reticulum into a N- terminal and a C-terminal products that remain physically associated with each other. The cleavage is necessary for calcium- activated chloride channel (CaCC) activation activity. {ECO 0000250|UniProtKB A8K7I4}. 
# Pfam	PF00092	VWA
# Pfam	PF08434	CLCA
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	CLCA4_HUMAN	Calcium-activated chloride channel regulator 4
# RecName	CLCA4_HUMAN	Calcium-activated chloride channel regulator 4, 110 kDa form
# RecName	CLCA4_HUMAN	Calcium-activated chloride channel regulator 4, 110 kDa form
# RecName	CLCA4_HUMAN	Calcium-activated chloride channel regulator 4, 30 kDa form
# RefSeq	NP_036260	NM_012128.3. [Q14CN2-1]
# SIMILARITY	Belongs to the CLCR family. {ECO	0000305}. 
# SIMILARITY	Contains 1 VWFA domain. {ECO:0000255|PROSITE- ProRule	PRU00219}.
# SMART	SM00327	VWA
# SUBCELLULAR LOCATION	CLCA4_HUMAN	Cell membrane {ECO 0000250}; Single-pass membrane protein {ECO 0000250}. Apical cell membrane {ECO 0000250}. Secreted {ECO 0000250}. Note=The C-terminus 30 kDa form is anchored to the membrane. The N-terminus 110 kDa form is released from the membrane triggered by an unknown stimulus. {ECO 0000250}. 
# SUPFAM	SSF53300	SSF53300
# TCDB	1.A.13.1	the epithelial chloride channel (e-clc) family
# TIGRFAMs	TIGR00868	hCaCC
# TISSUE SPECIFICITY	CLCA4_HUMAN	Primarily expressed in the digestive tract, mainly in colon. Detected in smaller amounts in brain, urogenital organs, testis, and salivary and mammary glands. Highly expressed in the epithelial layer and submucosal gland of the inferior turbinate mucosa. Lower levels in the epithelial layer of nasal polyp. {ECO 0000269|PubMed 10437792, ECO 0000269|PubMed 15490240, ECO 0000269|PubMed 16012037}. 
# UCSC	uc009wcs	human. [Q14CN2-1]
# eggNOG	ENOG410IEPS	Eukaryota
# eggNOG	ENOG410XPSZ	LUCA
BLAST	swissprot:CLCA4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CLCA4_HUMAN
COXPRESdb	22802	http://coxpresdb.jp/data/gene/22802.shtml
CleanEx	HS_CLCA4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CLCA4
DOI	10.1007/s00439-004-1190-y	http://dx.doi.org/10.1007/s00439-004-1190-y
DOI	10.1016/S0014-5793(99)00891-1	http://dx.doi.org/10.1016/S0014-5793(99)00891-1
DOI	10.1021/pr050492k	http://dx.doi.org/10.1021/pr050492k
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1080/00016480510028519	http://dx.doi.org/10.1080/00016480510028519
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-9-69	http://dx.doi.org/10.1186/1471-2164-9-69
EC_number	EC:3.4.-.- {ECO:0000250|UniProtKB:A8K7I4}	http://www.genome.jp/dbget-bin/www_bget?EC:3.4.-.- {ECO:0000250|UniProtKB:A8K7I4}
EMBL	AF127035	http://www.ebi.ac.uk/ena/data/view/AF127035
EMBL	AK293766	http://www.ebi.ac.uk/ena/data/view/AK293766
EMBL	AL122002	http://www.ebi.ac.uk/ena/data/view/AL122002
EMBL	AY358470	http://www.ebi.ac.uk/ena/data/view/AY358470
EMBL	BC113687	http://www.ebi.ac.uk/ena/data/view/BC113687
EMBL	BC113689	http://www.ebi.ac.uk/ena/data/view/BC113689
ENZYME	3.4.-.- {ECO:0000250|UniProtKB:A8K7I4}	http://enzyme.expasy.org/EC/3.4.-.- {ECO:0000250|UniProtKB:A8K7I4}
Ensembl	ENST00000370563	http://www.ensembl.org/id/ENST00000370563
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0004222	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004222
GO_function	GO:0005229	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005229
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0008233	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.410	http://www.cathdb.info/version/latest/superfamily/3.40.50.410
GeneCards	CLCA4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CLCA4
GeneID	22802	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22802
GeneTree	ENSGT00390000004810	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000004810
H-InvDB	HIX0000752	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0000752
HGNC	HGNC:2018	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2018
HOGENOM	HOG000015107	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000015107&db=HOGENOM6
HOVERGEN	HBG005560	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG005560&db=HOVERGEN
HPA	HPA017045	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA017045
InParanoid	Q14CN2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q14CN2
IntEnz	3.4.-.- {ECO:0000250|UniProtKB:A8K7I4}	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.-.- {ECO:0000250|UniProtKB:A8K7I4}
InterPro	IPR002035	http://www.ebi.ac.uk/interpro/entry/IPR002035
InterPro	IPR004727	http://www.ebi.ac.uk/interpro/entry/IPR004727
InterPro	IPR013642	http://www.ebi.ac.uk/interpro/entry/IPR013642
Jabion	22802	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=22802
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:22802	http://www.genome.jp/dbget-bin/www_bget?hsa:22802
KEGG_Orthology	KO:K05030	http://www.genome.jp/dbget-bin/www_bget?KO:K05030
KEGG_Pathway	ko04740	http://www.genome.jp/kegg-bin/show_pathway?ko04740
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
MIM	616857	http://www.ncbi.nlm.nih.gov/omim/616857
OMA	TIMENFT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TIMENFT
Orphanet	586	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=586
OrthoDB	EOG091G09E6	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G09E6
PROSITE	PS50234	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50234
PSORT	swissprot:CLCA4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CLCA4_HUMAN
PSORT-B	swissprot:CLCA4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CLCA4_HUMAN
PSORT2	swissprot:CLCA4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CLCA4_HUMAN
Pfam	PF00092	http://pfam.xfam.org/family/PF00092
Pfam	PF08434	http://pfam.xfam.org/family/PF08434
PharmGKB	PA26545	http://www.pharmgkb.org/do/serve?objId=PA26545&objCls=Gene
Phobius	swissprot:CLCA4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CLCA4_HUMAN
PhylomeDB	Q14CN2	http://phylomedb.org/?seqid=Q14CN2
ProteinModelPortal	Q14CN2	http://www.proteinmodelportal.org/query/uniprot/Q14CN2
PubMed	10437792	http://www.ncbi.nlm.nih.gov/pubmed/10437792
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15490240	http://www.ncbi.nlm.nih.gov/pubmed/15490240
PubMed	16012037	http://www.ncbi.nlm.nih.gov/pubmed/16012037
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	16740002	http://www.ncbi.nlm.nih.gov/pubmed/16740002
PubMed	18254958	http://www.ncbi.nlm.nih.gov/pubmed/18254958
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_036260	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_036260
SMART	SM00327	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00327
STRING	9606.ENSP00000359594	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000359594&targetmode=cogs
SUPFAM	SSF53300	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53300
TCDB	1.A.13.1	http://www.tcdb.org/search/result.php?tc=1.A.13.1
TIGRFAMs	TIGR00868	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00868
UCSC	uc009wcs	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc009wcs&org=rat
UniGene	Hs.567422	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.567422
UniProtKB	CLCA4_HUMAN	http://www.uniprot.org/uniprot/CLCA4_HUMAN
UniProtKB-AC	Q14CN2	http://www.uniprot.org/uniprot/Q14CN2
charge	swissprot:CLCA4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CLCA4_HUMAN
eggNOG	ENOG410IEPS	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IEPS
eggNOG	ENOG410XPSZ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPSZ
epestfind	swissprot:CLCA4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CLCA4_HUMAN
garnier	swissprot:CLCA4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CLCA4_HUMAN
helixturnhelix	swissprot:CLCA4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLCA4_HUMAN
hmoment	swissprot:CLCA4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CLCA4_HUMAN
iep	swissprot:CLCA4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CLCA4_HUMAN
inforesidue	swissprot:CLCA4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CLCA4_HUMAN
neXtProt	NX_Q14CN2	http://www.nextprot.org/db/entry/NX_Q14CN2
octanol	swissprot:CLCA4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CLCA4_HUMAN
pepcoil	swissprot:CLCA4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CLCA4_HUMAN
pepdigest	swissprot:CLCA4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CLCA4_HUMAN
pepinfo	swissprot:CLCA4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CLCA4_HUMAN
pepnet	swissprot:CLCA4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CLCA4_HUMAN
pepstats	swissprot:CLCA4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CLCA4_HUMAN
pepwheel	swissprot:CLCA4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CLCA4_HUMAN
pepwindow	swissprot:CLCA4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CLCA4_HUMAN
sigcleave	swissprot:CLCA4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CLCA4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	LAAT1_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6ZP29-1; Sequence=Displayed; Name=2; IsoId=Q6ZP29-2; Sequence=VSP_024151; Name=3; IsoId=Q6ZP29-3; Sequence=VSP_024152; 
# AltName	LAAT1_HUMAN	PQ-loop repeat-containing protein 2
# CCDS	CCDS195	-. [Q6ZP29-1]
# CCDS	CCDS30618	-. [Q6ZP29-3]
# ChiTaRS	PQLC2	human
# DOMAIN	LAAT1_HUMAN	The di-leucine motif mediates lysosomal localization. {ECO 0000269|PubMed 22822152}. 
# Ensembl	ENST00000375153	ENSP00000364295; ENSG00000040487. [Q6ZP29-1]
# Ensembl	ENST00000375155	ENSP00000364297; ENSG00000040487. [Q6ZP29-1]
# Ensembl	ENST00000400548	ENSP00000383395; ENSG00000040487. [Q6ZP29-3]
# ExpressionAtlas	Q6ZP29	baseline and differential
# FUNCTION	LAAT1_HUMAN	Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes. {ECO 0000269|PubMed 22822152, ECO 0000269|PubMed 23169667}. 
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0031301	integral component of organelle membrane; IDA:UniProtKB.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_function	GO:0015174	basic amino acid transmembrane transporter activity; ISS:UniProtKB.
# GO_function	GO:0015181	arginine transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015189	L-lysine transmembrane transporter activity; IDA:UniProtKB.
# GO_process	GO:0015809	arginine transport; IDA:UniProtKB.
# GO_process	GO:0015819	lysine transport; IDA:UniProtKB.
# GO_process	GO:0080144	amino acid homeostasis; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0042592	homeostatic process
# Genevisible	Q6ZP29	HS
# HGNC	HGNC:26001	PQLC2
# InterPro	IPR006603	PQ-loop_rpt
# MIM	614760	gene
# MISCELLANEOUS	May play a role in the export from lysosomes of cysteamine-cysteine mixed disulfide (MxD), the product formed upon treatment by cysteamine of patients with cystinosis, a disease characterized by the accumulation of cysteine in the lysosomes. {ECO:0000305|PubMed	23169667}. 
# Organism	LAAT1_HUMAN	Homo sapiens (Human)
# Pfam	PF04193	PQ-loop; 2
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-5223345	Miscellaneous transport and binding events
# RecName	LAAT1_HUMAN	Lysosomal amino acid transporter 1 homolog
# RefSeq	NP_001035214	NM_001040125.1. [Q6ZP29-1]
# RefSeq	NP_001035215	NM_001040126.1. [Q6ZP29-3]
# RefSeq	NP_001274460	NM_001287531.1. [Q6ZP29-2]
# RefSeq	NP_060235	NM_017765.2. [Q6ZP29-1]
# RefSeq	XP_005245973	XM_005245916.2. [Q6ZP29-1]
# RefSeq	XP_006710773	XM_006710710.2. [Q6ZP29-2]
# RefSeq	XP_006710774	XM_006710711.2. [Q6ZP29-2]
# SEQUENCE CAUTION	Sequence=BAA91088.1; Type=Frameshift; Positions=26; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the laat-1 family. {ECO	0000305}. 
# SIMILARITY	Contains 2 PQ-loop domains. {ECO	0000305}. 
# SMART	SM00679	CTNS; 2
# SUBCELLULAR LOCATION	LAAT1_HUMAN	Lysosome membrane {ECO 0000269|PubMed 22822152}; Multi-pass membrane protein {ECO 0000269|PubMed 22822152}. 
# TCDB	2.A.43.2	the lysosomal cystine transporter (lct) family
# UCSC	uc001bby	human. [Q6ZP29-1]
# eggNOG	ENOG4111FM2	LUCA
# eggNOG	KOG2913	Eukaryota
BLAST	swissprot:LAAT1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:LAAT1_HUMAN
COXPRESdb	54896	http://coxpresdb.jp/data/gene/54896.shtml
CleanEx	HS_PQLC2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_PQLC2
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.1211198109	http://dx.doi.org/10.1073/pnas.1211198109
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1220281	http://dx.doi.org/10.1126/science.1220281
EMBL	AK000327	http://www.ebi.ac.uk/ena/data/view/AK000327
EMBL	AK125580	http://www.ebi.ac.uk/ena/data/view/AK125580
EMBL	AK130171	http://www.ebi.ac.uk/ena/data/view/AK130171
EMBL	AK130175	http://www.ebi.ac.uk/ena/data/view/AK130175
EMBL	AK172745	http://www.ebi.ac.uk/ena/data/view/AK172745
EMBL	AL035413	http://www.ebi.ac.uk/ena/data/view/AL035413
EMBL	AL035413	http://www.ebi.ac.uk/ena/data/view/AL035413
EMBL	BC015324	http://www.ebi.ac.uk/ena/data/view/BC015324
Ensembl	ENST00000375153	http://www.ensembl.org/id/ENST00000375153
Ensembl	ENST00000375155	http://www.ensembl.org/id/ENST00000375155
Ensembl	ENST00000400548	http://www.ensembl.org/id/ENST00000400548
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0031301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031301
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_function	GO:0015174	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015174
GO_function	GO:0015181	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015181
GO_function	GO:0015189	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015189
GO_process	GO:0015809	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015809
GO_process	GO:0015819	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015819
GO_process	GO:0080144	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0080144
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GeneCards	PQLC2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=PQLC2
GeneID	54896	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54896
GeneTree	ENSGT00390000003344	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000003344
HGNC	HGNC:26001	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:26001
HOGENOM	HOG000293428	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000293428&db=HOGENOM6
HOVERGEN	HBG061486	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG061486&db=HOVERGEN
HPA	HPA057810	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA057810
InParanoid	Q6ZP29	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6ZP29
InterPro	IPR006603	http://www.ebi.ac.uk/interpro/entry/IPR006603
Jabion	54896	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=54896
KEGG_Gene	hsa:54896	http://www.genome.jp/dbget-bin/www_bget?hsa:54896
MIM	614760	http://www.ncbi.nlm.nih.gov/omim/614760
OMA	GNTMYGL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GNTMYGL
OrthoDB	EOG091G0C7E	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0C7E
PSORT	swissprot:LAAT1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:LAAT1_HUMAN
PSORT-B	swissprot:LAAT1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:LAAT1_HUMAN
PSORT2	swissprot:LAAT1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:LAAT1_HUMAN
Pfam	PF04193	http://pfam.xfam.org/family/PF04193
PharmGKB	PA134879718	http://www.pharmgkb.org/do/serve?objId=PA134879718&objCls=Gene
Phobius	swissprot:LAAT1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:LAAT1_HUMAN
PhylomeDB	Q6ZP29	http://phylomedb.org/?seqid=Q6ZP29
ProteinModelPortal	Q6ZP29	http://www.proteinmodelportal.org/query/uniprot/Q6ZP29
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	22822152	http://www.ncbi.nlm.nih.gov/pubmed/22822152
PubMed	23169667	http://www.ncbi.nlm.nih.gov/pubmed/23169667
Reactome	R-HSA-5223345	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5223345
RefSeq	NP_001035214	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001035214
RefSeq	NP_001035215	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001035215
RefSeq	NP_001274460	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001274460
RefSeq	NP_060235	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060235
RefSeq	XP_005245973	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005245973
RefSeq	XP_006710773	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006710773
RefSeq	XP_006710774	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006710774
SMART	SM00679	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00679
STRING	9606.ENSP00000364295	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000364295&targetmode=cogs
TCDB	2.A.43.2	http://www.tcdb.org/search/result.php?tc=2.A.43.2
UCSC	uc001bby	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001bby&org=rat
UniGene	Hs.647620	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.647620
UniProtKB	LAAT1_HUMAN	http://www.uniprot.org/uniprot/LAAT1_HUMAN
UniProtKB-AC	Q6ZP29	http://www.uniprot.org/uniprot/Q6ZP29
charge	swissprot:LAAT1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:LAAT1_HUMAN
eggNOG	ENOG4111FM2	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111FM2
eggNOG	KOG2913	http://eggnogapi.embl.de/nog_data/html/tree/KOG2913
epestfind	swissprot:LAAT1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:LAAT1_HUMAN
garnier	swissprot:LAAT1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:LAAT1_HUMAN
helixturnhelix	swissprot:LAAT1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:LAAT1_HUMAN
hmoment	swissprot:LAAT1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:LAAT1_HUMAN
iep	swissprot:LAAT1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:LAAT1_HUMAN
inforesidue	swissprot:LAAT1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:LAAT1_HUMAN
neXtProt	NX_Q6ZP29	http://www.nextprot.org/db/entry/NX_Q6ZP29
octanol	swissprot:LAAT1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:LAAT1_HUMAN
pepcoil	swissprot:LAAT1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:LAAT1_HUMAN
pepdigest	swissprot:LAAT1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:LAAT1_HUMAN
pepinfo	swissprot:LAAT1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:LAAT1_HUMAN
pepnet	swissprot:LAAT1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:LAAT1_HUMAN
pepstats	swissprot:LAAT1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:LAAT1_HUMAN
pepwheel	swissprot:LAAT1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:LAAT1_HUMAN
pepwindow	swissprot:LAAT1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:LAAT1_HUMAN
sigcleave	swissprot:LAAT1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:LAAT1_HUMAN
## Database	ID	URL or Descriptions
# AltName	MOT4_HUMAN	Solute carrier family 16 member 3
# BioGrid	114571	8
# CAUTION	Was initially assigned as monocarboxylate transporter 3 (MCT3) (PubMed:9425115). However, it was later shown that it corresponds to monocarboxylate transporter 4 (MCT4). {ECO	0000305|PubMed:9425115}. 
# CDD	cd06174	MFS
# ChiTaRS	SLC16A3	human
# DrugBank	DB00119	Pyruvic acid
# DrugBank	DB00627	Niacin
# DrugBank	DB01440	Gamma Hydroxybutyric Acid
# DrugBank	DB04398	Lactic Acid
# Ensembl	ENST00000392339	ENSP00000376150; ENSG00000141526
# Ensembl	ENST00000392341	ENSP00000376152; ENSG00000141526
# Ensembl	ENST00000581287	ENSP00000463978; ENSG00000141526
# Ensembl	ENST00000582743	ENSP00000462405; ENSG00000141526
# Ensembl	ENST00000617373	ENSP00000483212; ENSG00000141526
# Ensembl	ENST00000619321	ENSP00000482013; ENSG00000141526
# ExpressionAtlas	O15427	baseline and differential
# FUNCTION	MOT4_HUMAN	Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; IDA:HPA.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0015629	actin cytoskeleton; IDA:HPA.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0031965	nuclear membrane; IDA:HPA.
# GO_function	GO:0008028	monocarboxylic acid transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015129	lactate transmembrane transporter activity; EXP:Reactome.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_function	GO:0044822	poly(A) RNA binding; IDA:UniProtKB.
# GO_process	GO:0006090	pyruvate metabolic process; TAS:Reactome.
# GO_process	GO:0015718	monocarboxylic acid transport; TAS:ProtInc.
# GO_process	GO:0035879	plasma membrane lactate transport; IBA:GO_Central.
# GO_process	GO:0050900	leukocyte migration; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005856	cytoskeleton
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003723	RNA binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0002376	immune system process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0048870	cell motility
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	O15427	HS
# HGNC	HGNC:10924	SLC16A3
# INTERACTION	MOT4_HUMAN	Q8N9N5 BANP; NbExp=3; IntAct=EBI-7600166, EBI-744695; Q8IZU0 FAM9B; NbExp=3; IntAct=EBI-7600166, EBI-10175124; Q86WQ0 NR2C2AP; NbExp=3; IntAct=EBI-7600166, EBI-10260040; 
# IntAct	O15427	15
# InterPro	IPR004743	MCT
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# InterPro	IPR030756	MCT4
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	603877	gene
# Organism	MOT4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11360:SF27	PTHR11360:SF27
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-210991	Basigin interactions
# Reactome	R-HSA-433692	Proton-coupled monocarboxylate transport
# Reactome	R-HSA-70268	Pyruvate metabolism
# RecName	MOT4_HUMAN	Monocarboxylate transporter 4
# RefSeq	NP_001035887	NM_001042422.2
# RefSeq	NP_001035888	NM_001042423.2
# RefSeq	NP_001193879	NM_001206950.1
# RefSeq	NP_001193880	NM_001206951.1
# RefSeq	NP_001193881	NM_001206952.1
# RefSeq	NP_004198	NM_004207.3
# RefSeq	XP_011521909	XM_011523607.1
# SIMILARITY	Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	MOT4_HUMAN	Cell membrane; Multi-pass membrane protein. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.13	the major facilitator superfamily (mfs)
# TIGRFAMs	TIGR00892	2A0113
# TISSUE SPECIFICITY	MOT4_HUMAN	Highly expressed in skeletal muscle. 
# UCSC	uc002keb	human
# WEB RESOURCE	MOT4_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/SLC16A3ID44573ch17q25.html";
# eggNOG	ENOG410IMVU	Eukaryota
# eggNOG	ENOG4111A50	LUCA
BLAST	swissprot:MOT4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MOT4_HUMAN
BioCyc	ZFISH:ENSG00000141526-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000141526-MONOMER
COXPRESdb	9123	http://coxpresdb.jp/data/gene/9123.shtml
CleanEx	HS_SLC16A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC16A3
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/bj3290321	http://dx.doi.org/10.1042/bj3290321
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DrugBank	DB00119	http://www.drugbank.ca/drugs/DB00119
DrugBank	DB00627	http://www.drugbank.ca/drugs/DB00627
DrugBank	DB01440	http://www.drugbank.ca/drugs/DB01440
DrugBank	DB04398	http://www.drugbank.ca/drugs/DB04398
EMBL	AK127319	http://www.ebi.ac.uk/ena/data/view/AK127319
EMBL	BC112267	http://www.ebi.ac.uk/ena/data/view/BC112267
EMBL	BC112269	http://www.ebi.ac.uk/ena/data/view/BC112269
EMBL	U81800	http://www.ebi.ac.uk/ena/data/view/U81800
Ensembl	ENST00000392339	http://www.ensembl.org/id/ENST00000392339
Ensembl	ENST00000392341	http://www.ensembl.org/id/ENST00000392341
Ensembl	ENST00000581287	http://www.ensembl.org/id/ENST00000581287
Ensembl	ENST00000582743	http://www.ensembl.org/id/ENST00000582743
Ensembl	ENST00000617373	http://www.ensembl.org/id/ENST00000617373
Ensembl	ENST00000619321	http://www.ensembl.org/id/ENST00000619321
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0015629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015629
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0031965	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031965
GO_function	GO:0008028	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008028
GO_function	GO:0015129	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015129
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_function	GO:0044822	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044822
GO_process	GO:0006090	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006090
GO_process	GO:0015718	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015718
GO_process	GO:0035879	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035879
GO_process	GO:0050900	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050900
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003723	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0002376	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC16A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC16A3
GeneID	9123	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9123
GeneTree	ENSGT00760000118926	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118926
HGNC	HGNC:10924	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10924
HOGENOM	HOG000280688	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280688&db=HOGENOM6
HOVERGEN	HBG006384	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006384&db=HOVERGEN
HPA	CAB017490	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB017490
HPA	HPA021451	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA021451
InParanoid	O15427	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O15427
IntAct	O15427	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O15427*
InterPro	IPR004743	http://www.ebi.ac.uk/interpro/entry/IPR004743
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
InterPro	IPR030756	http://www.ebi.ac.uk/interpro/entry/IPR030756
Jabion	9123	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9123
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:9123	http://www.genome.jp/dbget-bin/www_bget?hsa:9123
KEGG_Orthology	KO:K08180	http://www.genome.jp/dbget-bin/www_bget?KO:K08180
MIM	603877	http://www.ncbi.nlm.nih.gov/omim/603877
MINT	MINT-4526381	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4526381
OMA	MGVPDTK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MGVPDTK
OrthoDB	EOG091G05SW	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05SW
PANTHER	PTHR11360:SF27	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11360:SF27
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:MOT4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MOT4_HUMAN
PSORT-B	swissprot:MOT4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MOT4_HUMAN
PSORT2	swissprot:MOT4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MOT4_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA35815	http://www.pharmgkb.org/do/serve?objId=PA35815&objCls=Gene
Phobius	swissprot:MOT4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MOT4_HUMAN
PhylomeDB	O15427	http://phylomedb.org/?seqid=O15427
ProteinModelPortal	O15427	http://www.proteinmodelportal.org/query/uniprot/O15427
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	9425115	http://www.ncbi.nlm.nih.gov/pubmed/9425115
Reactome	R-HSA-210991	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-210991
Reactome	R-HSA-433692	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-433692
Reactome	R-HSA-70268	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-70268
RefSeq	NP_001035887	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001035887
RefSeq	NP_001035888	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001035888
RefSeq	NP_001193879	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001193879
RefSeq	NP_001193880	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001193880
RefSeq	NP_001193881	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001193881
RefSeq	NP_004198	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004198
RefSeq	XP_011521909	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011521909
STRING	9606.ENSP00000376150	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000376150&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.13	http://www.tcdb.org/search/result.php?tc=2.A.1.13
TIGRFAMs	TIGR00892	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00892
UCSC	uc002keb	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002keb&org=rat
UniGene	Hs.500761	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.500761
UniProtKB	MOT4_HUMAN	http://www.uniprot.org/uniprot/MOT4_HUMAN
UniProtKB-AC	O15427	http://www.uniprot.org/uniprot/O15427
charge	swissprot:MOT4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MOT4_HUMAN
eggNOG	ENOG410IMVU	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IMVU
eggNOG	ENOG4111A50	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111A50
epestfind	swissprot:MOT4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MOT4_HUMAN
garnier	swissprot:MOT4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MOT4_HUMAN
helixturnhelix	swissprot:MOT4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MOT4_HUMAN
hmoment	swissprot:MOT4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MOT4_HUMAN
iep	swissprot:MOT4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MOT4_HUMAN
inforesidue	swissprot:MOT4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MOT4_HUMAN
neXtProt	NX_O15427	http://www.nextprot.org/db/entry/NX_O15427
octanol	swissprot:MOT4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MOT4_HUMAN
pepcoil	swissprot:MOT4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MOT4_HUMAN
pepdigest	swissprot:MOT4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MOT4_HUMAN
pepinfo	swissprot:MOT4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MOT4_HUMAN
pepnet	swissprot:MOT4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MOT4_HUMAN
pepstats	swissprot:MOT4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MOT4_HUMAN
pepwheel	swissprot:MOT4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MOT4_HUMAN
pepwindow	swissprot:MOT4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MOT4_HUMAN
sigcleave	swissprot:MOT4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MOT4_HUMAN
## Database	ID	URL or Descriptions
# AltName	NPT2C_HUMAN	Na(+)-dependent phosphate cotransporter 2C
# AltName	NPT2C_HUMAN	Sodium/inorganic phosphate cotransporter IIC
# AltName	NPT2C_HUMAN	Sodium/phosphate cotransporter 2C
# AltName	NPT2C_HUMAN	Solute carrier family 34 member 3
# BIOPHYSICOCHEMICAL PROPERTIES	Kinetic parameters: KM=79 uM for phosphate {ECO	0000269|PubMed:11880379}; 
# ChiTaRS	SLC34A3	human
# DISEASE	NPT2C_HUMAN	Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) [MIM 241530]  Autosomal recessive form of hypophosphatemia characterized by reduced renal phosphate reabsorption and rickets. Increased serum levels of 1,25-dihydroxyvitamin D lead to increase in urinary calcium excretion. {ECO 0000269|PubMed 16358214, ECO 0000269|PubMed 16358215}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000361134	ENSP00000355353; ENSG00000198569
# Ensembl	ENST00000538474	ENSP00000442397; ENSG00000198569
# FUNCTION	NPT2C_HUMAN	May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 20-30% of the apical influx. 
# GO_component	GO:0005737	cytoplasm; IBA:GO_Central.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005903	brush border; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0016324	apical plasma membrane; ISS:HGNC.
# GO_component	GO:0031526	brush border membrane; IEA:InterPro.
# GO_component	GO:0031982	vesicle; IBA:GO_Central.
# GO_function	GO:0005315	inorganic phosphate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015321	sodium-dependent phosphate transmembrane transporter activity; IDA:UniProtKB.
# GO_function	NPT2C_HUMAN	GO 0005436 sodium phosphate symporter activity; IDA UniProtKB.
# GO_process	GO:0006814	sodium ion transport; IDA:UniProtKB.
# GO_process	GO:0006817	phosphate ion transport; IDA:UniProtKB.
# GO_process	GO:0030643	cellular phosphate ion homeostasis; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0042592	homeostatic process
# Genevisible	Q8N130	HS
# HGNC	HGNC:20305	SLC34A3
# InterPro	IPR003841	Na/Pi_transpt
# InterPro	IPR029850	Na/Pi_transpt_2C
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H00214	[Inherited metabolic disease; Connective tissue disease; Urologic disease] Hereditary hypophophatemic rickets with hypercalciuria (HHRH)
# MIM	241530	phenotype
# MIM	609826	gene
# MISCELLANEOUS	A 2	1 stoichiometry to Na(+)/Pi is observed at pH 7.4. 
# Organism	NPT2C_HUMAN	Homo sapiens (Human)
# Orphanet	157215	Hereditary hypophosphatemic rickets with hypercalciuria
# PANTHER	PTHR10010:SF35	PTHR10010:SF35; 2
# Pfam	PF02690	Na_Pi_cotrans; 2
# Proteomes	UP000005640	Chromosome 9
# Reactome	R-HSA-427589	Type II Na+/Pi cotransporters
# RecName	NPT2C_HUMAN	Sodium-dependent phosphate transport protein 2C
# RefSeq	NP_001170787	NM_001177316.1
# RefSeq	NP_001170788	NM_001177317.1
# RefSeq	NP_543153	NM_080877.2
# RefSeq	XP_016869781	XM_017014292.1
# SIMILARITY	Belongs to the SLC34A transporter family. {ECO	0000305}.
# SUBCELLULAR LOCATION	NPT2C_HUMAN	Membrane; Multi-pass membrane protein. 
# TCDB	2.A.58.1:the phosphate	na(+) symporter (pnas) family
# TIGRFAMs	TIGR01013	2a58
# UCSC	uc004cmf	human
# eggNOG	COG1283	LUCA
# eggNOG	ENOG410IE8P	Eukaryota
BLAST	swissprot:NPT2C_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NPT2C_HUMAN
BioCyc	ZFISH:G66-31912-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31912-MONOMER
COG	COG1283	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1283
COXPRESdb	142680	http://coxpresdb.jp/data/gene/142680.shtml
CleanEx	HS_SLC34A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC34A3
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M200943200	http://dx.doi.org/10.1074/jbc.M200943200
DOI	10.1086/499409	http://dx.doi.org/10.1086/499409
DOI	10.1086/499410	http://dx.doi.org/10.1086/499410
EMBL	AB055000	http://www.ebi.ac.uk/ena/data/view/AB055000
EMBL	AK095999	http://www.ebi.ac.uk/ena/data/view/AK095999
EMBL	BX255925	http://www.ebi.ac.uk/ena/data/view/BX255925
Ensembl	ENST00000361134	http://www.ensembl.org/id/ENST00000361134
Ensembl	ENST00000538474	http://www.ensembl.org/id/ENST00000538474
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005903	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005903
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0031526	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031526
GO_component	GO:0031982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031982
GO_function	GO:0005315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005315
GO_function	GO:0005436	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005436
GO_function	GO:0015321	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015321
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0006817	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006817
GO_process	GO:0030643	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030643
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GeneCards	SLC34A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC34A3
GeneID	142680	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=142680
GeneTree	ENSGT00390000005032	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000005032
HGNC	HGNC:20305	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20305
HOGENOM	HOG000006550	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006550&db=HOGENOM6
HOVERGEN	HBG006527	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006527&db=HOVERGEN
HPA	HPA023776	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA023776
InParanoid	Q8N130	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8N130
InterPro	IPR003841	http://www.ebi.ac.uk/interpro/entry/IPR003841
InterPro	IPR029850	http://www.ebi.ac.uk/interpro/entry/IPR029850
Jabion	142680	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=142680
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00214	http://www.genome.jp/dbget-bin/www_bget?H00214
KEGG_Gene	hsa:142680	http://www.genome.jp/dbget-bin/www_bget?hsa:142680
KEGG_Orthology	KO:K14683	http://www.genome.jp/dbget-bin/www_bget?KO:K14683
MIM	241530	http://www.ncbi.nlm.nih.gov/omim/241530
MIM	609826	http://www.ncbi.nlm.nih.gov/omim/609826
OMA	NCGAFGP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NCGAFGP
Orphanet	157215	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=157215
OrthoDB	EOG091G0DR5	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0DR5
PANTHER	PTHR10010:SF35	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10010:SF35
PSORT	swissprot:NPT2C_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NPT2C_HUMAN
PSORT-B	swissprot:NPT2C_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NPT2C_HUMAN
PSORT2	swissprot:NPT2C_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NPT2C_HUMAN
Pfam	PF02690	http://pfam.xfam.org/family/PF02690
PharmGKB	PA134930298	http://www.pharmgkb.org/do/serve?objId=PA134930298&objCls=Gene
Phobius	swissprot:NPT2C_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NPT2C_HUMAN
PhylomeDB	Q8N130	http://phylomedb.org/?seqid=Q8N130
ProteinModelPortal	Q8N130	http://www.proteinmodelportal.org/query/uniprot/Q8N130
PubMed	11880379	http://www.ncbi.nlm.nih.gov/pubmed/11880379
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
PubMed	16358214	http://www.ncbi.nlm.nih.gov/pubmed/16358214
PubMed	16358215	http://www.ncbi.nlm.nih.gov/pubmed/16358215
Reactome	R-HSA-427589	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-427589
RefSeq	NP_001170787	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001170787
RefSeq	NP_001170788	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001170788
RefSeq	NP_543153	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_543153
RefSeq	XP_016869781	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016869781
STRING	9606.ENSP00000355353	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000355353&targetmode=cogs
STRING	COG1283	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1283&targetmode=cogs
TCDB	2.A.58.1	http://www.tcdb.org/search/result.php?tc=2.A.58.1
TIGRFAMs	TIGR01013	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01013
UCSC	uc004cmf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004cmf&org=rat
UniGene	Hs.432442	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.432442
UniProtKB	NPT2C_HUMAN	http://www.uniprot.org/uniprot/NPT2C_HUMAN
UniProtKB-AC	Q8N130	http://www.uniprot.org/uniprot/Q8N130
charge	swissprot:NPT2C_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NPT2C_HUMAN
eggNOG	COG1283	http://eggnogapi.embl.de/nog_data/html/tree/COG1283
eggNOG	ENOG410IE8P	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IE8P
epestfind	swissprot:NPT2C_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NPT2C_HUMAN
garnier	swissprot:NPT2C_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NPT2C_HUMAN
helixturnhelix	swissprot:NPT2C_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NPT2C_HUMAN
hmoment	swissprot:NPT2C_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NPT2C_HUMAN
iep	swissprot:NPT2C_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NPT2C_HUMAN
inforesidue	swissprot:NPT2C_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NPT2C_HUMAN
neXtProt	NX_Q8N130	http://www.nextprot.org/db/entry/NX_Q8N130
octanol	swissprot:NPT2C_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NPT2C_HUMAN
pepcoil	swissprot:NPT2C_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NPT2C_HUMAN
pepdigest	swissprot:NPT2C_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NPT2C_HUMAN
pepinfo	swissprot:NPT2C_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NPT2C_HUMAN
pepnet	swissprot:NPT2C_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NPT2C_HUMAN
pepstats	swissprot:NPT2C_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NPT2C_HUMAN
pepwheel	swissprot:NPT2C_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NPT2C_HUMAN
pepwindow	swissprot:NPT2C_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NPT2C_HUMAN
sigcleave	swissprot:NPT2C_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NPT2C_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GLRA1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=a; IsoId=P23415-1; Sequence=Displayed; Name=b; IsoId=P23415-2; Sequence=VSP_021142; 
# AltName	GLRA1_HUMAN	Glycine receptor 48 kDa subunit
# AltName	GLRA1_HUMAN	Glycine receptor strychnine-binding subunit
# BIOPHYSICOCHEMICAL PROPERTIES	GLRA1_HUMAN	Kinetic parameters  Note=A concentration of about 0.02 mM glycine results in half- maximal channel conductance for homopentamers. A concentration of 0.018 mM glycine results in half-maximal channel conductance for homopentamers upon heterologous expression in cultured human embryonic kidney cells (PubMed 9009272). A concentration of 0.027 mM glycine results in half-maximal channel conductance for homopentamers upon heterologous expression in cultured human embryonic kidney cells (PubMed 7920629). {ECO 0000269|PubMed 7920629, ECO 0000269|PubMed 9009272}; 
# CCDS	CCDS4320	-. [P23415-2]
# CCDS	CCDS54942	-. [P23415-1]
# DISEASE	GLRA1_HUMAN	Hyperekplexia 1 (HKPX1) [MIM 149400]  A neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli. {ECO 0000269|PubMed 10514101, ECO 0000269|PubMed 24108130, ECO 0000269|PubMed 7611730, ECO 0000269|PubMed 7881416, ECO 0000269|PubMed 7981700, ECO 0000269|PubMed 8298642, ECO 0000269|PubMed 8571969, ECO 0000269|PubMed 8733061, ECO 0000269|PubMed 9067762, ECO 0000269|PubMed 9920650, ECO 0000269|Ref.18}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	GLRA1_HUMAN	The channel pore is formed by pentameric assembly of the second transmembrane domain from all five subunits. In the absence of the extracellular domain, the channel is in a constitutively open conformation (PubMed 23994010). Channel opening is effected by an outward rotation of the transmembrane domains that increases the diameter of the pore (By similarity). {ECO 0000250|UniProtKB O93430, ECO 0000269|PubMed 23994010}. 
# DrugBank	DB00145	Glycine
# DrugBank	DB00228	Enflurane
# DrugBank	DB00431	Lindane
# DrugBank	DB00753	Isoflurane
# DrugBank	DB00898	Ethanol
# DrugBank	DB01028	Methoxyflurane
# DrugBank	DB01159	Halothane
# DrugBank	DB01189	Desflurane
# DrugBank	DB01236	Sevoflurane
# DrugBank	DB01381	Ginkgo biloba
# ENZYME REGULATION	GLRA1_HUMAN	Channel activity is potentiated by nanomolar concentrations of Zn(2+); half-maximal activation is observed with 37 nM Zn(2+) (PubMed 16144831). Inhibited by higher Zn(2+) levels; haf-maximal inhibition occurs at 20 uM Zn(2+) (PubMed 16144831). Inhibited by strychnine (PubMed 2155780, PubMed 16144831, PubMed 25445488). Inhibited by lindane (PubMed 25445488). Inhibited by picrotoxin (PubMed 22715885, PubMed 23994010, PubMed 25730860). Strychnine binding locks the channel in a closed conformation and prevents channel opening in response to extracellular glycine (By similarity). {ECO 0000250|UniProtKB O93430, ECO 0000269|PubMed 16144831, ECO 0000269|PubMed 2155780, ECO 0000269|PubMed 22715885, ECO 0000269|PubMed 23994010, ECO 0000269|PubMed 25445488, ECO 0000269|PubMed 25730860}. 
# Ensembl	ENST00000274576	ENSP00000274576; ENSG00000145888. [P23415-2]
# Ensembl	ENST00000455880	ENSP00000411593; ENSG00000145888. [P23415-1]
# ExpressionAtlas	P23415	baseline and differential
# FUNCTION	GLRA1_HUMAN	Glycine receptors are ligand-gated chloride channels (PubMed 23994010, PubMed 25730860). Channel opening is triggered by extracellular glycine (PubMed 2155780, PubMed 7920629, PubMed 14551753, PubMed 16144831, PubMed 22715885, PubMed 22973015, PubMed 25973519, PubMed 9009272). Channel opening is also triggered by taurine and beta-alanine (PubMed 16144831, PubMed 9009272). Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (PubMed 14551753). Plays an important role in the down-regulation of neuronal excitability (PubMed 8298642, PubMed 9009272). Contributes to the generation of inhibitory postsynaptic currents (PubMed 25445488). Channel activity is potentiated by ethanol (PubMed 25973519). Potentiation of channel activity by intoxicating levels ot ethanol contribute to the sedative effects of ethanol (By similarity). {ECO 0000250|UniProtKB Q64018, ECO 0000269|PubMed 14551753, ECO 0000269|PubMed 16144831, ECO 0000269|PubMed 2155780, ECO 0000269|PubMed 22715885, ECO 0000269|PubMed 22973015, ECO 0000269|PubMed 23994010, ECO 0000269|PubMed 25445488, ECO 0000269|PubMed 25730860, ECO 0000269|PubMed 25973519, ECO 0000269|PubMed 7920629, ECO 0000269|PubMed 7925268, ECO 0000269|PubMed 9009272, ECO 0000305|PubMed 8298642}. 
# GO_component	GO:0005783	endoplasmic reticulum; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0009897	external side of plasma membrane; IEA:Ensembl.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030425	dendrite; IEA:UniProtKB-SubCell.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0043005	neuron projection; ISS:UniProtKB.
# GO_component	GO:0043025	neuronal cell body; ISS:UniProtKB.
# GO_component	GO:0043204	perikaryon; IEA:UniProtKB-SubCell.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:UniProtKB.
# GO_component	GO:0045202	synapse; ISS:UniProtKB.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0060077	inhibitory synapse; IEA:Ensembl.
# GO_function	GO:0008270	zinc ion binding; IMP:UniProtKB.
# GO_function	GO:0016594	glycine binding; IDA:UniProtKB.
# GO_function	GO:0016934	extracellular-glycine-gated chloride channel activity; IDA:UniProtKB.
# GO_function	GO:0022824	transmitter-gated ion channel activity; IEA:InterPro.
# GO_function	GO:0030977	taurine binding; IDA:UniProtKB.
# GO_process	GO:0001508	action potential; IEA:Ensembl.
# GO_process	GO:0001964	startle response; IMP:UniProtKB.
# GO_process	GO:0002087	regulation of respiratory gaseous exchange by neurological system process; IEA:Ensembl.
# GO_process	GO:0006811	ion transport; IDA:UniProtKB.
# GO_process	GO:0006821	chloride transport; IDA:UniProtKB.
# GO_process	GO:0006936	muscle contraction; IMP:UniProtKB.
# GO_process	GO:0007218	neuropeptide signaling pathway; IDA:UniProtKB.
# GO_process	GO:0007340	acrosome reaction; IEA:Ensembl.
# GO_process	GO:0007601	visual perception; IEA:Ensembl.
# GO_process	GO:0007628	adult walking behavior; IEA:Ensembl.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0042391	regulation of membrane potential; IMP:MGI.
# GO_process	GO:0050884	neuromuscular process controlling posture; IEA:Ensembl.
# GO_process	GO:0051260	protein homooligomerization; IEA:Ensembl.
# GO_process	GO:0051291	protein heterooligomerization; IEA:Ensembl.
# GO_process	GO:0051970	negative regulation of transmission of nerve impulse; IMP:UniProtKB.
# GO_process	GO:0060012	synaptic transmission, glycinergic; ISS:UniProtKB.
# GO_process	GO:0060013	righting reflex; IEA:Ensembl.
# GO_process	GO:0060080	inhibitory postsynaptic potential; ISS:UniProtKB.
# GO_process	GO:0071230	cellular response to amino acid stimulus; IDA:UniProtKB.
# GO_process	GO:0071294	cellular response to zinc ion; IDA:UniProtKB.
# GO_process	GO:0071361	cellular response to ethanol; IDA:UniProtKB.
# GO_process	GO:0097305	response to alcohol; ISS:UniProtKB.
# GO_process	GO:1902476	chloride transmembrane transport; IDA:UniProtKB.
# GO_process	GO:2000344	positive regulation of acrosome reaction; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.70.170.10	-; 1.
# Genevisible	P23415	HS
# HGNC	HGNC:4326	GLRA1
# InterPro	IPR006028	GABAA/Glycine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR008127	Glycine_rcpt_A
# InterPro	IPR008128	Glycine_rcpt_A1
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00769	[Nervous system disease] Hyperekplexia
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# MIM	138491	gene
# MIM	149400	phenotype
# MISCELLANEOUS	The alpha subunit binds strychnine. {ECO:0000269|PubMed	2155780}. 
# Organism	GLRA1_HUMAN	Homo sapiens (Human)
# Orphanet	3197	Hereditary hyperekplexia
# PANTHER	PTHR18945	PTHR18945
# PDB	1MOT	NMR; -; A=277-304
# PDB	1VRY	NMR; -; A=278-337
# PDB	2M6B	NMR; -; A=244-453
# PDB	2M6I	NMR; -; A/B/C/D/E=244-453
# PDB	4X5T	X-ray; 3.50 A; A/B/C/D/E=246-338, A/B/C/D/E=418-446
# PIR	S12382	S12382
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00253	GABAARECEPTR
# PRINTS	PR01673	GLYRALPHA
# PRINTS	PR01674	GLYRALPHA1
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-975298	Ligand-gated ion channel transport
# RecName	GLRA1_HUMAN	Glycine receptor subunit alpha-1
# RefSeq	NP_000162	NM_000171.3. [P23415-2]
# RefSeq	NP_001139512	NM_001146040.1. [P23415-1]
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub- subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	GLRA1_HUMAN	Cell junction, synapse, postsynaptic cell membrane {ECO 0000250|UniProtKB Q64018}; Multi-pass membrane protein {ECO 0000250|UniProtKB Q64018}. Cell junction, synapse {ECO 0000250|UniProtKB Q64018}. Perikaryon {ECO 0000250|UniProtKB Q64018}. Cell projection, dendrite {ECO 0000250|UniProtKB Q64018}. Cell membrane {ECO 0000269|PubMed 14551753, ECO 0000269|PubMed 16144831, ECO 0000269|PubMed 2155780, ECO 0000269|PubMed 22715885, ECO 0000269|PubMed 22973015, ECO 0000269|PubMed 24108130, ECO 0000269|PubMed 25445488, ECO 0000269|PubMed 25730860, ECO 0000269|PubMed 25973519, ECO 0000269|PubMed 7920629, ECO 0000269|PubMed 7925268, ECO 0000269|PubMed 9009272}; Multi- pass membrane protein {ECO 0000269|PubMed 23994010, ECO 0000269|PubMed 25730860, ECO 0000305|PubMed 2155780}. 
# SUBUNIT	GLRA1_HUMAN	Homopentamer (in vitro) (PubMed 22715885, PubMed 22973015, PubMed 23994010, PubMed 25730860). Interacts with GLRB to form heteropentameric channels; this is probably the predominant form in vivo (PubMed 22715885, PubMed 22973015, PubMed 25445488). Heteropentamer composed of two GLRA1 and three GLRB (PubMed 22715885). Heteropentamer composed of three GLRA1 and two GLRB (PubMed 22973015). Both homopentamers and heteropentamers form functional ion channels, but their characteristics are subtly different (PubMed 14551753, PubMed 22715885, PubMed 22973015, PubMed 25445488, PubMed 23994010, PubMed 25730860). {ECO 0000269|PubMed 14551753, ECO 0000269|PubMed 22715885, ECO 0000269|PubMed 22973015, ECO 0000269|PubMed 23994010, ECO 0000269|PubMed 25445488, ECO 0000269|PubMed 25730860}. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TCDB	1.A.9.3	the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family
# TIGRFAMs	TIGR00860	LIC
# UCSC	uc003lur	human. [P23415-1]
# eggNOG	ENOG410XPWH	LUCA
# eggNOG	KOG3643	Eukaryota
BLAST	swissprot:GLRA1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GLRA1_HUMAN
BioCyc	ZFISH:ENSG00000145888-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000145888-MONOMER
COXPRESdb	2741	http://coxpresdb.jp/data/gene/2741.shtml
CleanEx	HS_GLRA1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GLRA1
DIP	DIP-48768N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48768N
DOI	10.1002/(SICI)1098-1004(1997)9:2<185::AID-HUMU14>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1997)9:2<185::AID-HUMU14>3.0.CO
DOI	10.1002/1531-8249(199910)46:4<634::AID-ANA12>3.0.CO	http://dx.doi.org/10.1002/1531-8249(199910)46:4<634::AID-ANA12>3.0.CO
DOI	10.1002/ana.410380115	http://dx.doi.org/10.1002/ana.410380115
DOI	10.1007/s00249-003-0286-y	http://dx.doi.org/10.1007/s00249-003-0286-y
DOI	10.1016/j.neuropharm.2014.10.026	http://dx.doi.org/10.1016/j.neuropharm.2014.10.026
DOI	10.1016/j.str.2013.07.014	http://dx.doi.org/10.1016/j.str.2013.07.014
DOI	10.1021/bi026767g	http://dx.doi.org/10.1021/bi026767g
DOI	10.1021/bi050256n	http://dx.doi.org/10.1021/bi050256n
DOI	10.1021/bi300063m	http://dx.doi.org/10.1021/bi300063m
DOI	10.1038/ng0694-131	http://dx.doi.org/10.1038/ng0694-131
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/ng1293-351	http://dx.doi.org/10.1038/ng1293-351
DOI	10.1073/pnas.1417864112	http://dx.doi.org/10.1073/pnas.1417864112
DOI	10.1074/jbc.M109.043448	http://dx.doi.org/10.1074/jbc.M109.043448
DOI	10.1074/jbc.M113.509240	http://dx.doi.org/10.1074/jbc.M113.509240
DOI	10.1074/jbc.M508303200	http://dx.doi.org/10.1074/jbc.M508303200
DOI	10.1093/emboj/16.1.110	http://dx.doi.org/10.1093/emboj/16.1.110
DOI	10.1093/hmg/3.12.2175	http://dx.doi.org/10.1093/hmg/3.12.2175
DOI	10.1093/hmg/3.7.1201	http://dx.doi.org/10.1093/hmg/3.7.1201
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/acer.12735	http://dx.doi.org/10.1111/acer.12735
DOI	10.1136/jmg.33.5.435	http://dx.doi.org/10.1136/jmg.33.5.435
DOI	10.1523/JNEUROSCI.2050-12.2012	http://dx.doi.org/10.1523/JNEUROSCI.2050-12.2012
DrugBank	DB00145	http://www.drugbank.ca/drugs/DB00145
DrugBank	DB00228	http://www.drugbank.ca/drugs/DB00228
DrugBank	DB00431	http://www.drugbank.ca/drugs/DB00431
DrugBank	DB00753	http://www.drugbank.ca/drugs/DB00753
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01028	http://www.drugbank.ca/drugs/DB01028
DrugBank	DB01159	http://www.drugbank.ca/drugs/DB01159
DrugBank	DB01189	http://www.drugbank.ca/drugs/DB01189
DrugBank	DB01236	http://www.drugbank.ca/drugs/DB01236
DrugBank	DB01381	http://www.drugbank.ca/drugs/DB01381
EMBL	AK312702	http://www.ebi.ac.uk/ena/data/view/AK312702
EMBL	BC074980	http://www.ebi.ac.uk/ena/data/view/BC074980
EMBL	BC114947	http://www.ebi.ac.uk/ena/data/view/BC114947
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	X52009	http://www.ebi.ac.uk/ena/data/view/X52009
Ensembl	ENST00000274576	http://www.ensembl.org/id/ENST00000274576
Ensembl	ENST00000455880	http://www.ensembl.org/id/ENST00000455880
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0009897	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009897
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0043005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043005
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0043204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043204
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_component	GO:0045202	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045202
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_component	GO:0060077	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060077
GO_function	GO:0008270	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270
GO_function	GO:0016594	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016594
GO_function	GO:0016934	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016934
GO_function	GO:0022824	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022824
GO_function	GO:0030977	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030977
GO_process	GO:0001508	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001508
GO_process	GO:0001964	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001964
GO_process	GO:0002087	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002087
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006821
GO_process	GO:0006936	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006936
GO_process	GO:0007218	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007218
GO_process	GO:0007340	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007340
GO_process	GO:0007601	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007601
GO_process	GO:0007628	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007628
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0050884	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050884
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:0051291	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051291
GO_process	GO:0051970	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051970
GO_process	GO:0060012	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060012
GO_process	GO:0060013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060013
GO_process	GO:0060080	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060080
GO_process	GO:0071230	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071230
GO_process	GO:0071294	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071294
GO_process	GO:0071361	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071361
GO_process	GO:0097305	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097305
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GO_process	GO:2000344	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000344
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	GLRA1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GLRA1
GeneID	2741	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2741
GeneTree	ENSGT00760000118821	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118821
HGNC	HGNC:4326	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4326
HOGENOM	HOG000231336	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231336&db=HOGENOM6
HOVERGEN	HBG051707	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051707&db=HOVERGEN
HPA	HPA016502	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA016502
InParanoid	P23415	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23415
IntAct	P23415	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23415*
InterPro	IPR006028	http://www.ebi.ac.uk/interpro/entry/IPR006028
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR008127	http://www.ebi.ac.uk/interpro/entry/IPR008127
InterPro	IPR008128	http://www.ebi.ac.uk/interpro/entry/IPR008128
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
Jabion	2741	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2741
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00769	http://www.genome.jp/dbget-bin/www_bget?H00769
KEGG_Gene	hsa:2741	http://www.genome.jp/dbget-bin/www_bget?hsa:2741
KEGG_Orthology	KO:K05193	http://www.genome.jp/dbget-bin/www_bget?KO:K05193
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
MIM	138491	http://www.ncbi.nlm.nih.gov/omim/138491
MIM	149400	http://www.ncbi.nlm.nih.gov/omim/149400
OMA	FNFAYGM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FNFAYGM
Orphanet	3197	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=3197
OrthoDB	EOG091G0805	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0805
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PDB	1MOT	http://www.ebi.ac.uk/pdbe-srv/view/entry/1MOT
PDB	1VRY	http://www.ebi.ac.uk/pdbe-srv/view/entry/1VRY
PDB	2M6B	http://www.ebi.ac.uk/pdbe-srv/view/entry/2M6B
PDB	2M6I	http://www.ebi.ac.uk/pdbe-srv/view/entry/2M6I
PDB	4X5T	http://www.ebi.ac.uk/pdbe-srv/view/entry/4X5T
PDBsum	1MOT	http://www.ebi.ac.uk/pdbsum/1MOT
PDBsum	1VRY	http://www.ebi.ac.uk/pdbsum/1VRY
PDBsum	2M6B	http://www.ebi.ac.uk/pdbsum/2M6B
PDBsum	2M6I	http://www.ebi.ac.uk/pdbsum/2M6I
PDBsum	4X5T	http://www.ebi.ac.uk/pdbsum/4X5T
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00253	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00253
PRINTS	PR01673	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01673
PRINTS	PR01674	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01674
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:GLRA1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GLRA1_HUMAN
PSORT-B	swissprot:GLRA1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GLRA1_HUMAN
PSORT2	swissprot:GLRA1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GLRA1_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA28727	http://www.pharmgkb.org/do/serve?objId=PA28727&objCls=Gene
Phobius	swissprot:GLRA1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GLRA1_HUMAN
PhylomeDB	P23415	http://phylomedb.org/?seqid=P23415
ProteinModelPortal	P23415	http://www.proteinmodelportal.org/query/uniprot/P23415
PubMed	10514101	http://www.ncbi.nlm.nih.gov/pubmed/10514101
PubMed	12667090	http://www.ncbi.nlm.nih.gov/pubmed/12667090
PubMed	14551753	http://www.ncbi.nlm.nih.gov/pubmed/14551753
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15952785	http://www.ncbi.nlm.nih.gov/pubmed/15952785
PubMed	16144831	http://www.ncbi.nlm.nih.gov/pubmed/16144831
PubMed	19861413	http://www.ncbi.nlm.nih.gov/pubmed/19861413
PubMed	2155780	http://www.ncbi.nlm.nih.gov/pubmed/2155780
PubMed	22715885	http://www.ncbi.nlm.nih.gov/pubmed/22715885
PubMed	22973015	http://www.ncbi.nlm.nih.gov/pubmed/22973015
PubMed	23994010	http://www.ncbi.nlm.nih.gov/pubmed/23994010
PubMed	24108130	http://www.ncbi.nlm.nih.gov/pubmed/24108130
PubMed	25445488	http://www.ncbi.nlm.nih.gov/pubmed/25445488
PubMed	25730860	http://www.ncbi.nlm.nih.gov/pubmed/25730860
PubMed	25973519	http://www.ncbi.nlm.nih.gov/pubmed/25973519
PubMed	7611730	http://www.ncbi.nlm.nih.gov/pubmed/7611730
PubMed	7881416	http://www.ncbi.nlm.nih.gov/pubmed/7881416
PubMed	7920629	http://www.ncbi.nlm.nih.gov/pubmed/7920629
PubMed	7925268	http://www.ncbi.nlm.nih.gov/pubmed/7925268
PubMed	7981700	http://www.ncbi.nlm.nih.gov/pubmed/7981700
PubMed	8298642	http://www.ncbi.nlm.nih.gov/pubmed/8298642
PubMed	8571969	http://www.ncbi.nlm.nih.gov/pubmed/8571969
PubMed	8733061	http://www.ncbi.nlm.nih.gov/pubmed/8733061
PubMed	9009272	http://www.ncbi.nlm.nih.gov/pubmed/9009272
PubMed	9067762	http://www.ncbi.nlm.nih.gov/pubmed/9067762
PubMed	9920650	http://www.ncbi.nlm.nih.gov/pubmed/9920650
Reactome	R-HSA-975298	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-975298
RefSeq	NP_000162	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000162
RefSeq	NP_001139512	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001139512
SMR	P23415	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23415
STRING	9606.ENSP00000411593	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000411593&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TCDB	1.A.9.3	http://www.tcdb.org/search/result.php?tc=1.A.9.3
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc003lur	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003lur&org=rat
UniGene	Hs.121490	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.121490
UniProtKB	GLRA1_HUMAN	http://www.uniprot.org/uniprot/GLRA1_HUMAN
UniProtKB-AC	P23415	http://www.uniprot.org/uniprot/P23415
charge	swissprot:GLRA1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GLRA1_HUMAN
eggNOG	ENOG410XPWH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPWH
eggNOG	KOG3643	http://eggnogapi.embl.de/nog_data/html/tree/KOG3643
epestfind	swissprot:GLRA1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GLRA1_HUMAN
garnier	swissprot:GLRA1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GLRA1_HUMAN
helixturnhelix	swissprot:GLRA1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLRA1_HUMAN
hmoment	swissprot:GLRA1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GLRA1_HUMAN
iep	swissprot:GLRA1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GLRA1_HUMAN
inforesidue	swissprot:GLRA1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GLRA1_HUMAN
neXtProt	NX_P23415	http://www.nextprot.org/db/entry/NX_P23415
octanol	swissprot:GLRA1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GLRA1_HUMAN
pepcoil	swissprot:GLRA1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GLRA1_HUMAN
pepdigest	swissprot:GLRA1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GLRA1_HUMAN
pepinfo	swissprot:GLRA1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GLRA1_HUMAN
pepnet	swissprot:GLRA1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GLRA1_HUMAN
pepstats	swissprot:GLRA1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GLRA1_HUMAN
pepwheel	swissprot:GLRA1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GLRA1_HUMAN
pepwindow	swissprot:GLRA1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GLRA1_HUMAN
sigcleave	swissprot:GLRA1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GLRA1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CLCN2_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=P51788-1; Sequence=Displayed; Name=2; IsoId=P51788-2; Sequence=VSP_007831, VSP_007832, VSP_036455; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; IsoId=P51788-3; Sequence=VSP_036456; Name=4; IsoId=P51788-4; Sequence=VSP_045457; Note=No experimental confirmation available.; Name=5; IsoId=P51788-5; Sequence=VSP_045458; Note=No experimental confirmation available.; 
# BioGrid	107595	19
# CCDS	CCDS3263	-. [P51788-1]
# CCDS	CCDS54690	-. [P51788-4]
# CCDS	CCDS54691	-. [P51788-3]
# CCDS	CCDS54692	-. [P51788-5]
# ChiTaRS	CLCN2	human
# DISEASE	CLCN2_HUMAN	Epilepsy, idiopathic generalized 11 (EIG11) [MIM 607628]  A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. {ECO 0000269|PubMed 19191339}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# DISEASE	CLCN2_HUMAN	Juvenile absence epilepsy 2 (JAE2) [MIM 607628]  A subtype of idiopathic generalized epilepsy characterized by onset occurring around puberty, absence seizures, generalized tonic- clonic seizures (GTCS), GTCS on awakening, and myoclonic seizures. {ECO 0000269|PubMed 12612585, ECO 0000269|PubMed 19710712}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry. 
# DISEASE	CLCN2_HUMAN	Juvenile myoclonic epilepsy 8 (EJM8) [MIM 607628]  A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue. {ECO 0000269|PubMed 19191339}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# DISEASE	CLCN2_HUMAN	Leukoencephalopathy with ataxia (LKPAT) [MIM 615651]  An autosomal recessive neurologic disorder with a characteristic pattern of white matter abnormalities on brain MRI. Affected individuals have prominent signal abnormalities and decreased apparent diffusion coefficient values in the posterior limbs of the internal capsules, middle cerebral peduncles, pyramidal tracts in the pons, and middle cerebellar peduncles, suggesting myelin microvacuolation. Clinical features include ataxia and unstable gait. More variable abnormalities may include visual field defects, headaches, and learning disabilities. {ECO 0000269|PubMed 23707145}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB01046	Lubiprostone
# Ensembl	ENST00000265593	ENSP00000265593; ENSG00000114859. [P51788-1]
# Ensembl	ENST00000344937	ENSP00000345056; ENSG00000114859. [P51788-3]
# Ensembl	ENST00000434054	ENSP00000400425; ENSG00000114859. [P51788-4]
# Ensembl	ENST00000457512	ENSP00000391928; ENSG00000114859. [P51788-5]
# ExpressionAtlas	P51788	baseline and differential
# FUNCTION	CLCN2_HUMAN	Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. {ECO 0000269|PubMed 19153159, ECO 0000269|PubMed 19191339}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_function	GO:0005247	voltage-gated chloride channel activity; TAS:Reactome.
# GO_function	GO:0031404	chloride ion binding; IBA:GO_Central.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0060041	retina development in camera-type eye; IEA:Ensembl.
# GO_process	GO:0060689	cell differentiation involved in salivary gland development; IEA:Ensembl.
# GO_process	GO:1902476	chloride transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.10.3080.10	-; 1.
# Genevisible	P51788	HS
# HGNC	HGNC:2020	CLCN2
# IntAct	P51788	31
# InterPro	IPR000644	CBS_dom
# InterPro	IPR001807	Cl-channel_volt-gated
# InterPro	IPR002244	Cl-channel-2
# InterPro	IPR014743	Cl-channel_core
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00808	[Nervous system disease] Familial infantile myoclonic epilepsy (FIME)
# KEGG_Pathway	ko04978	Mineral absorption
# MIM	600570	gene
# MIM	607628	phenotype
# MIM	615651	phenotype
# MISCELLANEOUS	The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (By similarity). {ECO	0000250}. 
# Organism	CLCN2_HUMAN	Homo sapiens (Human)
# Orphanet	307	Juvenile myoclonic epilepsy
# Orphanet	363540	Leukoencephalopathy with mild cerebellar ataxia and white matter edema
# PRINTS	PR00762	CLCHANNEL
# PRINTS	PR01113	CLCHANNEL2
# PROSITE	PS51371	CBS; 2
# PTM	CLCN2_HUMAN	Phosphorylated. Activated by dephosphorylation. {ECO 0000250|UniProtKB P35525}. 
# Pfam	PF00654	Voltage_CLC
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	CLCN2_HUMAN	Chloride channel protein 2
# RefSeq	NP_001164558	NM_001171087.2. [P51788-3]
# RefSeq	NP_001164559	NM_001171088.2. [P51788-4]
# RefSeq	NP_001164560	NM_001171089.2. [P51788-5]
# RefSeq	NP_004357	NM_004366.5. [P51788-1]
# SEQUENCE CAUTION	Sequence=AAH21578.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 2 CBS domains. {ECO:0000255|PROSITE- ProRule	PRU00703}. 
# SUBCELLULAR LOCATION	CLCN2_HUMAN	Cell membrane {ECO 0000250|UniProtKB P35525}; Multi-pass membrane protein. 
# SUPFAM	SSF81340	SSF81340
# TCDB	2.A.49.2.12	the chloride carrier/channel (clc) family
# TISSUE SPECIFICITY	Ubiquitously expressed. Moderately expressed in aortic and coronary vascular smooth muscle cells and expressed at a low level in aortic endothelial cells. {ECO:0000269|PubMed	10198195}. 
# UCSC	uc003foi	human. [P51788-1]
# eggNOG	COG0038	LUCA
# eggNOG	KOG0476	Eukaryota
BLAST	swissprot:CLCN2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CLCN2_HUMAN
BioCyc	ZFISH:ENSG00000114859-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000114859-MONOMER
COXPRESdb	1181	http://coxpresdb.jp/data/gene/1181.shtml
CleanEx	HS_CLCN2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CLCN2
DOI	10.1002/humu.20876	http://dx.doi.org/10.1002/humu.20876
DOI	10.1006/jmcc.1998.0901	http://dx.doi.org/10.1006/jmcc.1998.0901
DOI	10.1016/S1474-4422(13)70053-X	http://dx.doi.org/10.1016/S1474-4422(13)70053-X
DOI	10.1016/j.brainresbull.2009.01.008	http://dx.doi.org/10.1016/j.brainresbull.2009.01.008
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1038/ng0909-1043	http://dx.doi.org/10.1038/ng0909-1043
DOI	10.1038/ng0909-954	http://dx.doi.org/10.1038/ng0909-954
DOI	10.1038/ng1121	http://dx.doi.org/10.1038/ng1121
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1093/hmg/4.3.407	http://dx.doi.org/10.1093/hmg/4.3.407
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1113/jphysiol.2008.167353	http://dx.doi.org/10.1113/jphysiol.2008.167353
DOI	10.1159/000107528	http://dx.doi.org/10.1159/000107528
DrugBank	DB01046	http://www.drugbank.ca/drugs/DB01046
EMBL	AC078797	http://www.ebi.ac.uk/ena/data/view/AC078797
EMBL	AF026004	http://www.ebi.ac.uk/ena/data/view/AF026004
EMBL	AK298952	http://www.ebi.ac.uk/ena/data/view/AK298952
EMBL	AK302759	http://www.ebi.ac.uk/ena/data/view/AK302759
EMBL	BC021578	http://www.ebi.ac.uk/ena/data/view/BC021578
EMBL	BC072004	http://www.ebi.ac.uk/ena/data/view/BC072004
EMBL	S77770	http://www.ebi.ac.uk/ena/data/view/S77770
Ensembl	ENST00000265593	http://www.ensembl.org/id/ENST00000265593
Ensembl	ENST00000344937	http://www.ensembl.org/id/ENST00000344937
Ensembl	ENST00000434054	http://www.ensembl.org/id/ENST00000434054
Ensembl	ENST00000457512	http://www.ensembl.org/id/ENST00000457512
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_function	GO:0005247	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005247
GO_function	GO:0031404	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031404
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0060041	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060041
GO_process	GO:0060689	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060689
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.10.3080.10	http://www.cathdb.info/version/latest/superfamily/1.10.3080.10
GeneCards	CLCN2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CLCN2
GeneID	1181	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1181
GeneTree	ENSGT00760000119109	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119109
HGNC	HGNC:2020	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2020
HOGENOM	HOG000231297	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231297&db=HOGENOM6
HOVERGEN	HBG005332	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG005332&db=HOVERGEN
HPA	CAB009397	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB009397
HPA	HPA014545	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014545
HPA	HPA024108	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA024108
InParanoid	P51788	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P51788
IntAct	P51788	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P51788*
InterPro	IPR000644	http://www.ebi.ac.uk/interpro/entry/IPR000644
InterPro	IPR001807	http://www.ebi.ac.uk/interpro/entry/IPR001807
InterPro	IPR002244	http://www.ebi.ac.uk/interpro/entry/IPR002244
InterPro	IPR014743	http://www.ebi.ac.uk/interpro/entry/IPR014743
Jabion	1181	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1181
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00808	http://www.genome.jp/dbget-bin/www_bget?H00808
KEGG_Gene	hsa:1181	http://www.genome.jp/dbget-bin/www_bget?hsa:1181
KEGG_Orthology	KO:K05011	http://www.genome.jp/dbget-bin/www_bget?KO:K05011
KEGG_Pathway	ko04978	http://www.genome.jp/kegg-bin/show_pathway?ko04978
MIM	600570	http://www.ncbi.nlm.nih.gov/omim/600570
MIM	607628	http://www.ncbi.nlm.nih.gov/omim/607628
MIM	615651	http://www.ncbi.nlm.nih.gov/omim/615651
OMA	ESCEKRK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ESCEKRK
Orphanet	307	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=307
Orphanet	363540	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=363540
OrthoDB	EOG091G01RJ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01RJ
PRINTS	PR00762	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00762
PRINTS	PR01113	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01113
PROSITE	PS51371	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51371
PSORT	swissprot:CLCN2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CLCN2_HUMAN
PSORT-B	swissprot:CLCN2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CLCN2_HUMAN
PSORT2	swissprot:CLCN2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CLCN2_HUMAN
Pfam	PF00654	http://pfam.xfam.org/family/PF00654
PharmGKB	PA26547	http://www.pharmgkb.org/do/serve?objId=PA26547&objCls=Gene
Phobius	swissprot:CLCN2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CLCN2_HUMAN
PhylomeDB	P51788	http://phylomedb.org/?seqid=P51788
ProteinModelPortal	P51788	http://www.proteinmodelportal.org/query/uniprot/P51788
PubMed	10198195	http://www.ncbi.nlm.nih.gov/pubmed/10198195
PubMed	12612585	http://www.ncbi.nlm.nih.gov/pubmed/12612585
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	17762171	http://www.ncbi.nlm.nih.gov/pubmed/17762171
PubMed	19153159	http://www.ncbi.nlm.nih.gov/pubmed/19153159
PubMed	19191339	http://www.ncbi.nlm.nih.gov/pubmed/19191339
PubMed	19200853	http://www.ncbi.nlm.nih.gov/pubmed/19200853
PubMed	19710712	http://www.ncbi.nlm.nih.gov/pubmed/19710712
PubMed	19710717	http://www.ncbi.nlm.nih.gov/pubmed/19710717
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	23707145	http://www.ncbi.nlm.nih.gov/pubmed/23707145
PubMed	7795595	http://www.ncbi.nlm.nih.gov/pubmed/7795595
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_001164558	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001164558
RefSeq	NP_001164559	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001164559
RefSeq	NP_001164560	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001164560
RefSeq	NP_004357	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004357
STRING	9606.ENSP00000265593	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000265593&targetmode=cogs
SUPFAM	SSF81340	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81340
TCDB	2.A.49.2.12	http://www.tcdb.org/search/result.php?tc=2.A.49.2.12
UCSC	uc003foi	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003foi&org=rat
UniGene	Hs.436847	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.436847
UniProtKB	CLCN2_HUMAN	http://www.uniprot.org/uniprot/CLCN2_HUMAN
UniProtKB-AC	P51788	http://www.uniprot.org/uniprot/P51788
charge	swissprot:CLCN2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CLCN2_HUMAN
eggNOG	COG0038	http://eggnogapi.embl.de/nog_data/html/tree/COG0038
eggNOG	KOG0476	http://eggnogapi.embl.de/nog_data/html/tree/KOG0476
epestfind	swissprot:CLCN2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CLCN2_HUMAN
garnier	swissprot:CLCN2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CLCN2_HUMAN
helixturnhelix	swissprot:CLCN2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLCN2_HUMAN
hmoment	swissprot:CLCN2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CLCN2_HUMAN
iep	swissprot:CLCN2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CLCN2_HUMAN
inforesidue	swissprot:CLCN2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CLCN2_HUMAN
neXtProt	NX_P51788	http://www.nextprot.org/db/entry/NX_P51788
octanol	swissprot:CLCN2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CLCN2_HUMAN
pepcoil	swissprot:CLCN2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CLCN2_HUMAN
pepdigest	swissprot:CLCN2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CLCN2_HUMAN
pepinfo	swissprot:CLCN2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CLCN2_HUMAN
pepnet	swissprot:CLCN2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CLCN2_HUMAN
pepstats	swissprot:CLCN2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CLCN2_HUMAN
pepwheel	swissprot:CLCN2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CLCN2_HUMAN
pepwindow	swissprot:CLCN2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CLCN2_HUMAN
sigcleave	swissprot:CLCN2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CLCN2_HUMAN
## Database	ID	URL or Descriptions
# AltName	KCNJ2_HUMAN	Cardiac inward rectifier potassium channel
# AltName	KCNJ2_HUMAN	Inward rectifier K(+) channel Kir2.1
# AltName	KCNJ2_HUMAN	Potassium channel, inwardly rectifying subfamily J member 2
# BioGrid	109961	3
# DISEASE	KCNJ2_HUMAN	Atrial fibrillation, familial, 9 (ATFB9) [MIM 613980]  A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. {ECO 0000269|PubMed 15922306}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	KCNJ2_HUMAN	Long QT syndrome 7 (LQT7) [MIM 170390]  A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. Long QT syndrome type 7 manifests itself as a clinical triad consisting of potassium-sensitive periodic paralysis, ventricular ectopy and dysmorphic features. {ECO 0000269|PubMed 11371347, ECO 0000269|PubMed 12148092, ECO 0000269|PubMed 12163457, ECO 0000269|PubMed 16571646, ECO 0000269|PubMed 17324964}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	KCNJ2_HUMAN	Short QT syndrome 3 (SQT3) [MIM 609622]  A heart disorder characterized by idiopathic persistently and uniformly short QT interval on ECG in the absence of structural heart disease in affected individuals. It causes syncope and sudden death. SQT3 has a unique ECG phenotype characterized by asymmetrical T waves. {ECO 0000269|PubMed 15761194}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000243457	ENSP00000243457; ENSG00000123700
# Ensembl	ENST00000535240	ENSP00000441848; ENSG00000123700
# FUNCTION	KCNJ2_HUMAN	Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium. 
# GO_component	GO:0005790	smooth endoplasmic reticulum; IEA:Ensembl.
# GO_component	GO:0005791	rough endoplasmic reticulum; IEA:Ensembl.
# GO_component	GO:0005794	Golgi apparatus; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IDA:BHF-UCL.
# GO_component	GO:0014704	intercalated disc; IEA:Ensembl.
# GO_component	GO:0030315	T-tubule; IEA:Ensembl.
# GO_component	GO:0031224	intrinsic component of membrane; IDA:UniProtKB.
# GO_component	GO:0043025	neuronal cell body; IEA:Ensembl.
# GO_component	GO:0043197	dendritic spine; IEA:Ensembl.
# GO_function	GO:0005242	inward rectifier potassium channel activity; IDA:UniProtKB.
# GO_function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding; IDA:BHF-UCL.
# GO_function	GO:0015467	G-protein activated inward rectifier potassium channel activity; TAS:Reactome.
# GO_function	GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization; IMP:BHF-UCL.
# GO_process	GO:0006813	potassium ion transport; IDA:UniProtKB.
# GO_process	GO:0010107	potassium ion import; IDA:BHF-UCL.
# GO_process	GO:0014861	regulation of skeletal muscle contraction via regulation of action potential; IMP:BHF-UCL.
# GO_process	GO:0015693	magnesium ion transport; IEA:Ensembl.
# GO_process	GO:0030007	cellular potassium ion homeostasis; TAS:BHF-UCL.
# GO_process	GO:0051289	protein homotetramerization; IDA:UniProtKB.
# GO_process	GO:0055119	relaxation of cardiac muscle; IMP:BHF-UCL.
# GO_process	GO:0060075	regulation of resting membrane potential; TAS:BHF-UCL.
# GO_process	GO:0060306	regulation of membrane repolarization; IDA:BHF-UCL.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:0071260	cellular response to mechanical stimulus; IEA:Ensembl.
# GO_process	GO:0071805	potassium ion transmembrane transport; IDA:BHF-UCL.
# GO_process	GO:0086002	cardiac muscle cell action potential involved in contraction; IMP:BHF-UCL.
# GO_process	GO:0086004	regulation of cardiac muscle cell contraction; IEA:Ensembl.
# GO_process	GO:0086011	membrane repolarization during action potential; IMP:BHF-UCL.
# GO_process	GO:0086012	membrane depolarization during cardiac muscle cell action potential; TAS:BHF-UCL.
# GO_process	GO:0086013	membrane repolarization during cardiac muscle cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086091	regulation of heart rate by cardiac conduction; IMP:BHF-UCL.
# GO_process	GO:0090076	relaxation of skeletal muscle; IMP:BHF-UCL.
# GO_process	GO:1901381	positive regulation of potassium ion transmembrane transport; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0008289	lipid binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.40.1400	-; 1.
# Genevisible	P63252	HS
# HGNC	HGNC:6263	KCNJ2
# IntAct	P63252	5
# InterPro	IPR003271	K_chnl_inward-rec_Kir2.1
# InterPro	IPR013518	K_chnl_inward-rec_Kir_cyto
# InterPro	IPR013673	K_chnl_inward-rec_Kir_N
# InterPro	IPR014756	Ig_E-set
# InterPro	IPR016449	K_chnl_inward-rec_Kir
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00215:[Inherited metabolic disease; Nervous system disease; Muscular disease] Andersen-Tawil syndrome (ATS) [DS	H00748]
# KEGG_Disease	H00720	[Cardiovascular disease] Jervell and Lange-Nielsen syndrome (JLNS)
# KEGG_Disease	H00725	[Cardiovascular disease] Short QT syndrome
# KEGG_Disease	H00731	[Cardiovascular disease] Atrial fibrillation
# KEGG_Disease	H00748	[Musculoskeletal disease; Nervous system disease; Inherited metabolic disease] Andersen-Tawil syndrome (ATS)
# KEGG_Pathway	ko04725	Cholinergic synapse
# KEGG_Pathway	ko04971	Gastric acid secretion
# MIM	170390	phenotype
# MIM	600681	gene
# MIM	609622	phenotype
# MIM	613980	phenotype
# Organism	KCNJ2_HUMAN	Homo sapiens (Human)
# Orphanet	334	Familial atrial fibrillation
# Orphanet	37553	Cardiodysrhythmic potassium-sensitive periodic paralysis
# Orphanet	51083	Familial short QT syndrome
# PANTHER	PTHR11767	PTHR11767
# PIR	I38727	I38727
# PIRSF	PIRSF005465	GIRK_kir
# PRINTS	PR01320	KIRCHANNEL
# PRINTS	PR01324	KIR21CHANNEL
# PTM	KCNJ2_HUMAN	S-nitrosylation increases the open probability and inward rectifying currents. {ECO 0000269|PubMed 19608980}. 
# Pfam	PF01007	IRK
# Pfam	PF08466	IRK_N
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-1296041	Activation of G protein gated Potassium channels
# Reactome	R-HSA-1296053	Classical Kir channels
# Reactome	R-HSA-5576886	Phase 4 - resting membrane potential
# Reactome	R-HSA-997272	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
# RecName	KCNJ2_HUMAN	Inward rectifier potassium channel 2
# RefSeq	NP_000882	NM_000891.2
# SIMILARITY	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCNJ2_HUMAN	Membrane; Multi-pass membrane protein. Membrane; Lipid-anchor {ECO 0000269|PubMed 25043870}. 
# SUBUNIT	Homomultimeric and heteromultimeric association with KCNJ4/Kir2.3. Association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role in its localization and trafficking (By similarity). {ECO	0000250}. 
# SUPFAM	SSF81296	SSF81296
# TCDB	1.A.2.1	inward rectifier k(+) channel (irk-c) family
# TISSUE SPECIFICITY	KCNJ2_HUMAN	Heart, brain, placenta, lung, skeletal muscle, and kidney. Diffusely distributed throughout the brain. 
# UCSC	uc002jir	human
# eggNOG	ENOG410XQ62	LUCA
# eggNOG	KOG3827	Eukaryota
BLAST	swissprot:KCNJ2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNJ2_HUMAN
BioCyc	ZFISH:ENSG00000123700-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000123700-MONOMER
COXPRESdb	3759	http://coxpresdb.jp/data/gene/3759.shtml
CleanEx	HS_KCNJ2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNJ2
DOI	10.1016/0378-1119(95)00244-Z	http://dx.doi.org/10.1016/0378-1119(95)00244-Z
DOI	10.1016/S0014-5793(01)02202-5	http://dx.doi.org/10.1016/S0014-5793(01)02202-5
DOI	10.1016/S0092-8674(01)00342-7	http://dx.doi.org/10.1016/S0092-8674(01)00342-7
DOI	10.1016/j.ab.2014.07.006	http://dx.doi.org/10.1016/j.ab.2014.07.006
DOI	10.1016/j.bbrc.2005.05.054	http://dx.doi.org/10.1016/j.bbrc.2005.05.054
DOI	10.1073/pnas.102609499	http://dx.doi.org/10.1073/pnas.102609499
DOI	10.1086/342360	http://dx.doi.org/10.1086/342360
DOI	10.1093/hmg/ddm034	http://dx.doi.org/10.1093/hmg/ddm034
DOI	10.1111/j.1469-7793.1998.303bw.x	http://dx.doi.org/10.1111/j.1469-7793.1998.303bw.x
DOI	10.1136/jmg.2006.040816	http://dx.doi.org/10.1136/jmg.2006.040816
DOI	10.1161/01.RES.0000162101.76263.8c	http://dx.doi.org/10.1161/01.RES.0000162101.76263.8c
DOI	10.1161/CIRCRESAHA.109.197558	http://dx.doi.org/10.1161/CIRCRESAHA.109.197558
DOI	10.1172/JCI15183	http://dx.doi.org/10.1172/JCI15183
EMBL	AF011904	http://www.ebi.ac.uk/ena/data/view/AF011904
EMBL	AF021139	http://www.ebi.ac.uk/ena/data/view/AF021139
EMBL	AF153819	http://www.ebi.ac.uk/ena/data/view/AF153819
EMBL	AF153820	http://www.ebi.ac.uk/ena/data/view/AF153820
EMBL	U12507	http://www.ebi.ac.uk/ena/data/view/U12507
EMBL	U16861	http://www.ebi.ac.uk/ena/data/view/U16861
EMBL	U22413	http://www.ebi.ac.uk/ena/data/view/U22413
EMBL	U24055	http://www.ebi.ac.uk/ena/data/view/U24055
Ensembl	ENST00000243457	http://www.ensembl.org/id/ENST00000243457
Ensembl	ENST00000535240	http://www.ensembl.org/id/ENST00000535240
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005790	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005790
GO_component	GO:0005791	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005791
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0014704	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014704
GO_component	GO:0030315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030315
GO_component	GO:0031224	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031224
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0043197	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043197
GO_function	GO:0005242	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005242
GO_function	GO:0005546	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005546
GO_function	GO:0015467	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015467
GO_function	GO:0086008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086008
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0010107	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010107
GO_process	GO:0014861	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014861
GO_process	GO:0015693	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015693
GO_process	GO:0030007	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030007
GO_process	GO:0051289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051289
GO_process	GO:0055119	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055119
GO_process	GO:0060075	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060075
GO_process	GO:0060306	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060306
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:0071260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071260
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GO_process	GO:0086002	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086002
GO_process	GO:0086004	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086004
GO_process	GO:0086011	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086011
GO_process	GO:0086012	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086012
GO_process	GO:0086013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086013
GO_process	GO:0086091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086091
GO_process	GO:0090076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090076
GO_process	GO:1901381	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901381
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.40.1400	http://www.cathdb.info/version/latest/superfamily/2.60.40.1400
GeneCards	KCNJ2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNJ2
GeneID	3759	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3759
GeneTree	ENSGT00760000118842	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118842
HGNC	HGNC:6263	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6263
HOGENOM	HOG000237325	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237325&db=HOGENOM6
HOVERGEN	HBG006178	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG006178&db=HOVERGEN
HPA	HPA029109	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA029109
InParanoid	P63252	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P63252
IntAct	P63252	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P63252*
InterPro	IPR003271	http://www.ebi.ac.uk/interpro/entry/IPR003271
InterPro	IPR013518	http://www.ebi.ac.uk/interpro/entry/IPR013518
InterPro	IPR013673	http://www.ebi.ac.uk/interpro/entry/IPR013673
InterPro	IPR014756	http://www.ebi.ac.uk/interpro/entry/IPR014756
InterPro	IPR016449	http://www.ebi.ac.uk/interpro/entry/IPR016449
Jabion	3759	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3759
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00215	http://www.genome.jp/dbget-bin/www_bget?H00215
KEGG_Disease	H00720	http://www.genome.jp/dbget-bin/www_bget?H00720
KEGG_Disease	H00725	http://www.genome.jp/dbget-bin/www_bget?H00725
KEGG_Disease	H00731	http://www.genome.jp/dbget-bin/www_bget?H00731
KEGG_Disease	H00748	http://www.genome.jp/dbget-bin/www_bget?H00748
KEGG_Gene	hsa:3759	http://www.genome.jp/dbget-bin/www_bget?hsa:3759
KEGG_Orthology	KO:K04996	http://www.genome.jp/dbget-bin/www_bget?KO:K04996
KEGG_Pathway	ko04725	http://www.genome.jp/kegg-bin/show_pathway?ko04725
KEGG_Pathway	ko04971	http://www.genome.jp/kegg-bin/show_pathway?ko04971
MIM	170390	http://www.ncbi.nlm.nih.gov/omim/170390
MIM	600681	http://www.ncbi.nlm.nih.gov/omim/600681
MIM	609622	http://www.ncbi.nlm.nih.gov/omim/609622
MIM	613980	http://www.ncbi.nlm.nih.gov/omim/613980
OMA	HNATVAM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HNATVAM
Orphanet	334	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=334
Orphanet	37553	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=37553
Orphanet	51083	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=51083
OrthoDB	EOG091G08HC	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08HC
PANTHER	PTHR11767	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11767
PRINTS	PR01320	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01320
PRINTS	PR01324	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01324
PSORT	swissprot:KCNJ2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNJ2_HUMAN
PSORT-B	swissprot:KCNJ2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNJ2_HUMAN
PSORT2	swissprot:KCNJ2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNJ2_HUMAN
Pfam	PF01007	http://pfam.xfam.org/family/PF01007
Pfam	PF08466	http://pfam.xfam.org/family/PF08466
PharmGKB	PA214	http://www.pharmgkb.org/do/serve?objId=PA214&objCls=Gene
Phobius	swissprot:KCNJ2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNJ2_HUMAN
PhylomeDB	P63252	http://phylomedb.org/?seqid=P63252
ProteinModelPortal	P63252	http://www.proteinmodelportal.org/query/uniprot/P63252
PubMed	11240146	http://www.ncbi.nlm.nih.gov/pubmed/11240146
PubMed	11371347	http://www.ncbi.nlm.nih.gov/pubmed/11371347
PubMed	12032359	http://www.ncbi.nlm.nih.gov/pubmed/12032359
PubMed	12148092	http://www.ncbi.nlm.nih.gov/pubmed/12148092
PubMed	12163457	http://www.ncbi.nlm.nih.gov/pubmed/12163457
PubMed	15761194	http://www.ncbi.nlm.nih.gov/pubmed/15761194
PubMed	15922306	http://www.ncbi.nlm.nih.gov/pubmed/15922306
PubMed	16571646	http://www.ncbi.nlm.nih.gov/pubmed/16571646
PubMed	17324964	http://www.ncbi.nlm.nih.gov/pubmed/17324964
PubMed	19608980	http://www.ncbi.nlm.nih.gov/pubmed/19608980
PubMed	25043870	http://www.ncbi.nlm.nih.gov/pubmed/25043870
PubMed	7590287	http://www.ncbi.nlm.nih.gov/pubmed/7590287
PubMed	7696590	http://www.ncbi.nlm.nih.gov/pubmed/7696590
PubMed	7840300	http://www.ncbi.nlm.nih.gov/pubmed/7840300
PubMed	9490857	http://www.ncbi.nlm.nih.gov/pubmed/9490857
Reactome	R-HSA-1296041	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296041
Reactome	R-HSA-1296053	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296053
Reactome	R-HSA-5576886	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576886
Reactome	R-HSA-997272	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-997272
RefSeq	NP_000882	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000882
SMR	P63252	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P63252
STRING	9606.ENSP00000243457	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000243457&targetmode=cogs
SUPFAM	SSF81296	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81296
TCDB	1.A.2.1	http://www.tcdb.org/search/result.php?tc=1.A.2.1
UCSC	uc002jir	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002jir&org=rat
UniGene	Hs.1547	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.1547
UniProtKB	KCNJ2_HUMAN	http://www.uniprot.org/uniprot/KCNJ2_HUMAN
UniProtKB-AC	P63252	http://www.uniprot.org/uniprot/P63252
charge	swissprot:KCNJ2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNJ2_HUMAN
eggNOG	ENOG410XQ62	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ62
eggNOG	KOG3827	http://eggnogapi.embl.de/nog_data/html/tree/KOG3827
epestfind	swissprot:KCNJ2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNJ2_HUMAN
garnier	swissprot:KCNJ2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNJ2_HUMAN
helixturnhelix	swissprot:KCNJ2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNJ2_HUMAN
hmoment	swissprot:KCNJ2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNJ2_HUMAN
iep	swissprot:KCNJ2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNJ2_HUMAN
inforesidue	swissprot:KCNJ2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNJ2_HUMAN
neXtProt	NX_P63252	http://www.nextprot.org/db/entry/NX_P63252
octanol	swissprot:KCNJ2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNJ2_HUMAN
pepcoil	swissprot:KCNJ2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNJ2_HUMAN
pepdigest	swissprot:KCNJ2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNJ2_HUMAN
pepinfo	swissprot:KCNJ2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNJ2_HUMAN
pepnet	swissprot:KCNJ2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNJ2_HUMAN
pepstats	swissprot:KCNJ2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNJ2_HUMAN
pepwheel	swissprot:KCNJ2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNJ2_HUMAN
pepwindow	swissprot:KCNJ2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNJ2_HUMAN
sigcleave	swissprot:KCNJ2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNJ2_HUMAN
## Database	ID	URL or Descriptions
# AltName	TM38A_HUMAN	Transmembrane protein 38A
# BioGrid	122504	7
# ChiTaRS	TMEM38A	human
# DOMAIN	TM38A_HUMAN	The second transmembrane domain has been proposed to cross only half of the lipid bilayer and to loop back into the cytosol, so that the domains on each side of this domain are both found on the cytosolic face of the membrane. The cytosolic loop may form an ion-conducting pore. 
# Ensembl	ENST00000187762	ENSP00000187762; ENSG00000072954
# ExpressionAtlas	Q9H6F2	baseline and differential
# FUNCTION	TM38A_HUMAN	Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity). {ECO 0000250}. 
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0031965	nuclear membrane; NAS:BHF-UCL.
# GO_component	GO:0033017	sarcoplasmic reticulum membrane; NAS:BHF-UCL.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005267	potassium channel activity; TAS:BHF-UCL.
# GO_function	GO:0015269	calcium-activated potassium channel activity; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# Genevisible	Q9H6F2	HS
# HGNC	HGNC:28462	TMEM38A
# InterPro	IPR007866	TRIC_channel
# MIM	611235	gene
# Organism	TM38A_HUMAN	Homo sapiens (Human)
# Pfam	PF05197	TRIC
# Proteomes	UP000005640	Chromosome 19
# RecName	TM38A_HUMAN	Trimeric intracellular cation channel type A
# RefSeq	NP_076979	NM_024074.2
# SIMILARITY	Belongs to the TMEM38 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	TM38A_HUMAN	Sarcoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane {ECO 0000250}. 
# SUBUNIT	Homotrimer. {ECO	0000250}. 
# UCSC	uc002nes	human
# eggNOG	ENOG410XQ0P	LUCA
# eggNOG	KOG3944	Eukaryota
BLAST	swissprot:TM38A_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TM38A_HUMAN
BioCyc	ZFISH:ENSG00000072954-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000072954-MONOMER
COXPRESdb	79041	http://coxpresdb.jp/data/gene/79041.shtml
CleanEx	HS_TMEM38A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TMEM38A
DOI	10.1038/nature05928	http://dx.doi.org/10.1038/nature05928
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AK025981	http://www.ebi.ac.uk/ena/data/view/AK025981
EMBL	AK292764	http://www.ebi.ac.uk/ena/data/view/AK292764
EMBL	BC001195	http://www.ebi.ac.uk/ena/data/view/BC001195
EMBL	CH471106	http://www.ebi.ac.uk/ena/data/view/CH471106
Ensembl	ENST00000187762	http://www.ensembl.org/id/ENST00000187762
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0031965	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031965
GO_component	GO:0033017	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033017
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_function	GO:0015269	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015269
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GeneCards	TMEM38A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TMEM38A
GeneID	79041	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79041
GeneTree	ENSGT00390000018845	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000018845
HGNC	HGNC:28462	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:28462
HOGENOM	HOG000037929	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000037929&db=HOGENOM6
HOVERGEN	HBG059853	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG059853&db=HOVERGEN
HPA	HPA048100	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA048100
HPA	HPA050463	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA050463
InParanoid	Q9H6F2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9H6F2
InterPro	IPR007866	http://www.ebi.ac.uk/interpro/entry/IPR007866
Jabion	79041	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=79041
KEGG_Gene	hsa:79041	http://www.genome.jp/dbget-bin/www_bget?hsa:79041
MIM	611235	http://www.ncbi.nlm.nih.gov/omim/611235
OMA	YKCVSFL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YKCVSFL
OrthoDB	EOG091G0GQP	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0GQP
PSORT	swissprot:TM38A_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TM38A_HUMAN
PSORT-B	swissprot:TM38A_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TM38A_HUMAN
PSORT2	swissprot:TM38A_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TM38A_HUMAN
Pfam	PF05197	http://pfam.xfam.org/family/PF05197
PharmGKB	PA134891982	http://www.pharmgkb.org/do/serve?objId=PA134891982&objCls=Gene
Phobius	swissprot:TM38A_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TM38A_HUMAN
PhylomeDB	Q9H6F2	http://phylomedb.org/?seqid=Q9H6F2
ProteinModelPortal	Q9H6F2	http://www.proteinmodelportal.org/query/uniprot/Q9H6F2
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17611541	http://www.ncbi.nlm.nih.gov/pubmed/17611541
RefSeq	NP_076979	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_076979
STRING	9606.ENSP00000187762	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000187762&targetmode=cogs
UCSC	uc002nes	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002nes&org=rat
UniGene	Hs.436068	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.436068
UniProtKB	TM38A_HUMAN	http://www.uniprot.org/uniprot/TM38A_HUMAN
UniProtKB-AC	Q9H6F2	http://www.uniprot.org/uniprot/Q9H6F2
charge	swissprot:TM38A_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TM38A_HUMAN
eggNOG	ENOG410XQ0P	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ0P
eggNOG	KOG3944	http://eggnogapi.embl.de/nog_data/html/tree/KOG3944
epestfind	swissprot:TM38A_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TM38A_HUMAN
garnier	swissprot:TM38A_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TM38A_HUMAN
helixturnhelix	swissprot:TM38A_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TM38A_HUMAN
hmoment	swissprot:TM38A_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TM38A_HUMAN
iep	swissprot:TM38A_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TM38A_HUMAN
inforesidue	swissprot:TM38A_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TM38A_HUMAN
neXtProt	NX_Q9H6F2	http://www.nextprot.org/db/entry/NX_Q9H6F2
octanol	swissprot:TM38A_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TM38A_HUMAN
pepcoil	swissprot:TM38A_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TM38A_HUMAN
pepdigest	swissprot:TM38A_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TM38A_HUMAN
pepinfo	swissprot:TM38A_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TM38A_HUMAN
pepnet	swissprot:TM38A_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TM38A_HUMAN
pepstats	swissprot:TM38A_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TM38A_HUMAN
pepwheel	swissprot:TM38A_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TM38A_HUMAN
pepwindow	swissprot:TM38A_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TM38A_HUMAN
sigcleave	swissprot:TM38A_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TM38A_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S36A3_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q495N2-1; Sequence=Displayed; Name=2; IsoId=Q495N2-2; Sequence=VSP_032601, VSP_032602; Note=No experimental confirmation available.; Name=3; IsoId=Q495N2-3; Sequence=VSP_032602; 
# AltName	S36A3_HUMAN	Solute carrier family 36 member 3
# AltName	S36A3_HUMAN	Tramdorin-2
# CCDS	CCDS4314	-. [Q495N2-1]
# CCDS	CCDS47316	-. [Q495N2-3]
# Ensembl	ENST00000335230	ENSP00000334750; ENSG00000186334. [Q495N2-1]
# Ensembl	ENST00000377713	ENSP00000366942; ENSG00000186334. [Q495N2-3]
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015078	hydrogen ion transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015180	L-alanine transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015187	glycine transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015193	L-proline transmembrane transporter activity; IBA:GO_Central.
# GO_function	S36A3_HUMAN	GO 0005280 hydrogen amino acid symporter activity; IBA GO_Central.
# GO_process	GO:0015816	glycine transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# HGNC	HGNC:19659	SLC36A3
# InterPro	IPR013057	AA_transpt_TM
# KEGG_Brite	ko02001	Solute carrier family
# MIM	608332	gene
# Organism	S36A3_HUMAN	Homo sapiens (Human)
# PTM	S36A3_HUMAN	Isoform 3 is phosphorylated on Tyr-175. 
# Pfam	PF01490	Aa_trans
# Proteomes	UP000005640	Chromosome 5
# RecName	S36A3_HUMAN	Proton-coupled amino acid transporter 3
# RefSeq	NP_001138489	NM_001145017.1. [Q495N2-3]
# RefSeq	NP_861439	NM_181774.3. [Q495N2-1]
# SIMILARITY	Belongs to the amino acid/polyamine transporter 2 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S36A3_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	2.A.18.8	the amino acid/auxin permease (aaap) family
# TISSUE SPECIFICITY	Specifically expressed in testis. {ECO:0000269|PubMed	15058382}. 
# UCSC	uc003ltw	human. [Q495N2-1]
BLAST	swissprot:S36A3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S36A3_HUMAN
BioCyc	ZFISH:G66-31592-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31592-MONOMER
COXPRESdb	285641	http://coxpresdb.jp/data/gene/285641.shtml
CleanEx	HS_SLC36A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC36A3
DOI	10.1007/s00335-003-2319-3	http://dx.doi.org/10.1007/s00335-003-2319-3
DOI	10.1016/S0888-7543(03)00099-5	http://dx.doi.org/10.1016/S0888-7543(03)00099-5
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AK127978	http://www.ebi.ac.uk/ena/data/view/AK127978
EMBL	AK131483	http://www.ebi.ac.uk/ena/data/view/AK131483
EMBL	AY162215	http://www.ebi.ac.uk/ena/data/view/AY162215
EMBL	BC101092	http://www.ebi.ac.uk/ena/data/view/BC101092
EMBL	BC101093	http://www.ebi.ac.uk/ena/data/view/BC101093
EMBL	BC101094	http://www.ebi.ac.uk/ena/data/view/BC101094
EMBL	BC101095	http://www.ebi.ac.uk/ena/data/view/BC101095
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
Ensembl	ENST00000335230	http://www.ensembl.org/id/ENST00000335230
Ensembl	ENST00000377713	http://www.ensembl.org/id/ENST00000377713
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005280	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005280
GO_function	GO:0015078	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015078
GO_function	GO:0015180	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015180
GO_function	GO:0015187	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015187
GO_function	GO:0015193	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015193
GO_process	GO:0015816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015816
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC36A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC36A3
GeneID	285641	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=285641
GeneTree	ENSGT00390000011245	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000011245
HGNC	HGNC:19659	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:19659
HOGENOM	HOG000006823	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006823&db=HOGENOM6
HOVERGEN	HBG057183	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG057183&db=HOVERGEN
InParanoid	Q495N2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q495N2
InterPro	IPR013057	http://www.ebi.ac.uk/interpro/entry/IPR013057
Jabion	285641	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=285641
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:285641	http://www.genome.jp/dbget-bin/www_bget?hsa:285641
KEGG_Orthology	KO:K14209	http://www.genome.jp/dbget-bin/www_bget?KO:K14209
MIM	608332	http://www.ncbi.nlm.nih.gov/omim/608332
OMA	AMMYSLE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AMMYSLE
OrthoDB	EOG091G079T	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G079T
PSORT	swissprot:S36A3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S36A3_HUMAN
PSORT-B	swissprot:S36A3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S36A3_HUMAN
PSORT2	swissprot:S36A3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S36A3_HUMAN
Pfam	PF01490	http://pfam.xfam.org/family/PF01490
PharmGKB	PA134875494	http://www.pharmgkb.org/do/serve?objId=PA134875494&objCls=Gene
Phobius	swissprot:S36A3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S36A3_HUMAN
PhylomeDB	Q495N2	http://phylomedb.org/?seqid=Q495N2
ProteinModelPortal	Q495N2	http://www.proteinmodelportal.org/query/uniprot/Q495N2
PubMed	12809675	http://www.ncbi.nlm.nih.gov/pubmed/12809675
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15058382	http://www.ncbi.nlm.nih.gov/pubmed/15058382
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
RefSeq	NP_001138489	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001138489
RefSeq	NP_861439	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_861439
TCDB	2.A.18.8	http://www.tcdb.org/search/result.php?tc=2.A.18.8
UCSC	uc003ltw	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ltw&org=rat
UniGene	Hs.720893	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.720893
UniProtKB	S36A3_HUMAN	http://www.uniprot.org/uniprot/S36A3_HUMAN
UniProtKB-AC	Q495N2	http://www.uniprot.org/uniprot/Q495N2
charge	swissprot:S36A3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S36A3_HUMAN
epestfind	swissprot:S36A3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S36A3_HUMAN
garnier	swissprot:S36A3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S36A3_HUMAN
helixturnhelix	swissprot:S36A3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S36A3_HUMAN
hmoment	swissprot:S36A3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S36A3_HUMAN
iep	swissprot:S36A3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S36A3_HUMAN
inforesidue	swissprot:S36A3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S36A3_HUMAN
neXtProt	NX_Q495N2	http://www.nextprot.org/db/entry/NX_Q495N2
octanol	swissprot:S36A3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S36A3_HUMAN
pepcoil	swissprot:S36A3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S36A3_HUMAN
pepdigest	swissprot:S36A3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S36A3_HUMAN
pepinfo	swissprot:S36A3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S36A3_HUMAN
pepnet	swissprot:S36A3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S36A3_HUMAN
pepstats	swissprot:S36A3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S36A3_HUMAN
pepwheel	swissprot:S36A3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S36A3_HUMAN
pepwindow	swissprot:S36A3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S36A3_HUMAN
sigcleave	swissprot:S36A3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S36A3_HUMAN
## Database	ID	URL or Descriptions
# AltName	S39A7_HUMAN	Histidine-rich membrane protein Ke4
# AltName	S39A7_HUMAN	Really interesting new gene 5 protein
# AltName	S39A7_HUMAN	Solute carrier family 39 member 7
# AltName	S39A7_HUMAN	Zrt-, Irt-like protein 7
# BioGrid	113652	19
# ChiTaRS	SLC39A7	human
# Ensembl	ENST00000374675	ENSP00000363807; ENSG00000112473
# Ensembl	ENST00000374677	ENSP00000363809; ENSG00000112473
# Ensembl	ENST00000383213	ENSP00000372700; ENSG00000206288
# Ensembl	ENST00000383214	ENSP00000372701; ENSG00000206288
# Ensembl	ENST00000416369	ENSP00000403583; ENSG00000229802
# Ensembl	ENST00000418477	ENSP00000416439; ENSG00000226614
# Ensembl	ENST00000423043	ENSP00000389623; ENSG00000226614
# Ensembl	ENST00000431735	ENSP00000410656; ENSG00000224399
# Ensembl	ENST00000441854	ENSP00000391735; ENSG00000229802
# Ensembl	ENST00000441953	ENSP00000413027; ENSG00000224399
# Ensembl	ENST00000443773	ENSP00000407093; ENSG00000227402
# Ensembl	ENST00000456261	ENSP00000414145; ENSG00000227402
# ExpressionAtlas	Q92504	baseline and differential
# FUNCTION	S39A7_HUMAN	Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca(2+), as well as by exogenous Zn(2+). {ECO 0000269|PubMed 14525538, ECO 0000269|PubMed 15705588, ECO 0000269|PubMed 22317921}. 
# GO_component	GO:0005654	nucleoplasm; IDA:HPA.
# GO_component	GO:0005783	endoplasmic reticulum; IDA:HPA.
# GO_component	GO:0005789	endoplasmic reticulum membrane; TAS:Reactome.
# GO_component	GO:0005794	Golgi apparatus; IEA:UniProtKB-SubCell.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005385	zinc ion transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0006882	cellular zinc ion homeostasis; IBA:GO_Central.
# GO_process	GO:0071577	zinc II ion transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q92504	HS
# HGNC	HGNC:4927	SLC39A7
# INDUCTION	Down-regulated by Zn(+2). {ECO:0000269|PubMed	15705588}. 
# INTERACTION	S39A7_HUMAN	P68400 CSNK2A1; NbExp=4; IntAct=EBI-1051105, EBI-347804; 
# IntAct	Q92504	19
# InterPro	IPR003689	ZIP
# KEGG_Brite	ko02001	Solute carrier family
# MIM	601416	gene
# Organism	S39A7_HUMAN	Homo sapiens (Human)
# PTM	S39A7_HUMAN	Rapidly phosphorylated by CK2 following Zn(2+) treatment. This phosphorylation is required for efficient cytosolic Zn(2+) release. {ECO 0000269|PubMed 22317921}. 
# Pfam	PF02535	Zip
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-442380	Zinc influx into cells by the SLC39 gene family
# RecName	S39A7_HUMAN	Zinc transporter SLC39A7
# RefSeq	NP_001070984	NM_001077516.1
# RefSeq	NP_001275706	NM_001288777.1
# RefSeq	NP_008910	NM_006979.2
# SIMILARITY	Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	S39A7_HUMAN	Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane. 
# TCDB	2.A.5.4	the zinc (zn(2+))-iron (fe(2+)) permease (zip) family
# TISSUE SPECIFICITY	S39A7_HUMAN	Widely expressed. {ECO 0000269|PubMed 14525538, ECO 0000269|PubMed 15705588}. 
# UCSC	uc003odf	human
# eggNOG	COG0428	LUCA
# eggNOG	KOG2693	Eukaryota
BLAST	swissprot:S39A7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S39A7_HUMAN
BioCyc	ZFISH:ENSG00000112473-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000112473-MONOMER
COG	COG0428	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0428
COXPRESdb	7922	http://coxpresdb.jp/data/gene/7922.shtml
CleanEx	HS_SLC39A7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC39A7
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/geno.1996.0405	http://dx.doi.org/10.1006/geno.1996.0405
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr0704130	http://dx.doi.org/10.1021/pr0704130
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1042/BJ20031183	http://dx.doi.org/10.1042/BJ20031183
DOI	10.1074/jbc.M412188200	http://dx.doi.org/10.1074/jbc.M412188200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2002585	http://dx.doi.org/10.1126/scisignal.2002585
EMBL	AF117221	http://www.ebi.ac.uk/ena/data/view/AF117221
EMBL	AL031228	http://www.ebi.ac.uk/ena/data/view/AL031228
EMBL	AL645940	http://www.ebi.ac.uk/ena/data/view/AL645940
EMBL	AL662824	http://www.ebi.ac.uk/ena/data/view/AL662824
EMBL	AL844527	http://www.ebi.ac.uk/ena/data/view/AL844527
EMBL	BC000645	http://www.ebi.ac.uk/ena/data/view/BC000645
EMBL	CH471081	http://www.ebi.ac.uk/ena/data/view/CH471081
EMBL	CR354565	http://www.ebi.ac.uk/ena/data/view/CR354565
EMBL	CR759733	http://www.ebi.ac.uk/ena/data/view/CR759733
EMBL	CR759786	http://www.ebi.ac.uk/ena/data/view/CR759786
EMBL	CR759786	http://www.ebi.ac.uk/ena/data/view/CR759786
EMBL	CR936877	http://www.ebi.ac.uk/ena/data/view/CR936877
EMBL	CR936877	http://www.ebi.ac.uk/ena/data/view/CR936877
EMBL	D82060	http://www.ebi.ac.uk/ena/data/view/D82060
Ensembl	ENST00000374675	http://www.ensembl.org/id/ENST00000374675
Ensembl	ENST00000374677	http://www.ensembl.org/id/ENST00000374677
Ensembl	ENST00000383213	http://www.ensembl.org/id/ENST00000383213
Ensembl	ENST00000383214	http://www.ensembl.org/id/ENST00000383214
Ensembl	ENST00000416369	http://www.ensembl.org/id/ENST00000416369
Ensembl	ENST00000418477	http://www.ensembl.org/id/ENST00000418477
Ensembl	ENST00000423043	http://www.ensembl.org/id/ENST00000423043
Ensembl	ENST00000431735	http://www.ensembl.org/id/ENST00000431735
Ensembl	ENST00000441854	http://www.ensembl.org/id/ENST00000441854
Ensembl	ENST00000441953	http://www.ensembl.org/id/ENST00000441953
Ensembl	ENST00000443773	http://www.ensembl.org/id/ENST00000443773
Ensembl	ENST00000456261	http://www.ensembl.org/id/ENST00000456261
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005385
GO_process	GO:0006882	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006882
GO_process	GO:0071577	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071577
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC39A7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC39A7
GeneID	7922	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7922
GeneTree	ENSGT00760000119115	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119115
HGNC	HGNC:4927	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4927
HOGENOM	HOG000185308	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000185308&db=HOGENOM6
HOVERGEN	HBG001037	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG001037&db=HOVERGEN
HPA	HPA053999	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA053999
InParanoid	Q92504	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q92504
IntAct	Q92504	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q92504*
InterPro	IPR003689	http://www.ebi.ac.uk/interpro/entry/IPR003689
Jabion	7922	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7922
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:7922	http://www.genome.jp/dbget-bin/www_bget?hsa:7922
KEGG_Orthology	KO:K14713	http://www.genome.jp/dbget-bin/www_bget?KO:K14713
MIM	601416	http://www.ncbi.nlm.nih.gov/omim/601416
OMA	QEDFHGH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QEDFHGH
OrthoDB	EOG091G0GD1	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0GD1
PSORT	swissprot:S39A7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S39A7_HUMAN
PSORT-B	swissprot:S39A7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S39A7_HUMAN
PSORT2	swissprot:S39A7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S39A7_HUMAN
Pfam	PF02535	http://pfam.xfam.org/family/PF02535
PharmGKB	PA29305	http://www.pharmgkb.org/do/serve?objId=PA29305&objCls=Gene
Phobius	swissprot:S39A7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S39A7_HUMAN
PhylomeDB	Q92504	http://phylomedb.org/?seqid=Q92504
ProteinModelPortal	Q92504	http://www.proteinmodelportal.org/query/uniprot/Q92504
PubMed	14525538	http://www.ncbi.nlm.nih.gov/pubmed/14525538
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15705588	http://www.ncbi.nlm.nih.gov/pubmed/15705588
PubMed	18088087	http://www.ncbi.nlm.nih.gov/pubmed/18088087
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	22317921	http://www.ncbi.nlm.nih.gov/pubmed/22317921
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	8812499	http://www.ncbi.nlm.nih.gov/pubmed/8812499
Reactome	R-HSA-442380	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442380
RefSeq	NP_001070984	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001070984
RefSeq	NP_001275706	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001275706
RefSeq	NP_008910	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_008910
STRING	9606.ENSP00000363807	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000363807&targetmode=cogs
STRING	COG0428	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0428&targetmode=cogs
TCDB	2.A.5.4	http://www.tcdb.org/search/result.php?tc=2.A.5.4
UCSC	uc003odf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003odf&org=rat
UniGene	Hs.631995	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.631995
UniProtKB	S39A7_HUMAN	http://www.uniprot.org/uniprot/S39A7_HUMAN
UniProtKB-AC	Q92504	http://www.uniprot.org/uniprot/Q92504
charge	swissprot:S39A7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S39A7_HUMAN
eggNOG	COG0428	http://eggnogapi.embl.de/nog_data/html/tree/COG0428
eggNOG	KOG2693	http://eggnogapi.embl.de/nog_data/html/tree/KOG2693
epestfind	swissprot:S39A7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S39A7_HUMAN
garnier	swissprot:S39A7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S39A7_HUMAN
helixturnhelix	swissprot:S39A7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S39A7_HUMAN
hmoment	swissprot:S39A7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S39A7_HUMAN
iep	swissprot:S39A7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S39A7_HUMAN
inforesidue	swissprot:S39A7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S39A7_HUMAN
neXtProt	NX_Q92504	http://www.nextprot.org/db/entry/NX_Q92504
octanol	swissprot:S39A7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S39A7_HUMAN
pepcoil	swissprot:S39A7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S39A7_HUMAN
pepdigest	swissprot:S39A7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S39A7_HUMAN
pepinfo	swissprot:S39A7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S39A7_HUMAN
pepnet	swissprot:S39A7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S39A7_HUMAN
pepstats	swissprot:S39A7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S39A7_HUMAN
pepwheel	swissprot:S39A7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S39A7_HUMAN
pepwindow	swissprot:S39A7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S39A7_HUMAN
sigcleave	swissprot:S39A7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S39A7_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	NPT4_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O00476-1; Sequence=Displayed; Name=2; IsoId=O00476-2; Sequence=VSP_042888; Note=No experimental confirmation available.; 
# AltName	NPT4_HUMAN	Na(+)/PI cotransporter 4
# AltName	NPT4_HUMAN	Sodium/phosphate cotransporter 4
# AltName	NPT4_HUMAN	Solute carrier family 17 member 3
# CCDS	CCDS4566	-. [O00476-1]
# CCDS	CCDS47385	-. [O00476-2]
# CDD	cd06174	MFS
# Ensembl	ENST00000360657	ENSP00000353873; ENSG00000124564. [O00476-1]
# Ensembl	ENST00000361703	ENSP00000355307; ENSG00000124564. [O00476-1]
# Ensembl	ENST00000397060	ENSP00000380250; ENSG00000124564. [O00476-2]
# ExpressionAtlas	O00476	baseline and differential
# FUNCTION	NPT4_HUMAN	Isoform 2  voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport. 
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005789	endoplasmic reticulum membrane; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_component	GO:0031526	brush border membrane; ISS:UniProtKB.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IDA:UniProtKB.
# GO_function	GO:0008308	voltage-gated anion channel activity; IDA:UniProtKB.
# GO_function	GO:0008514	organic anion transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015143	urate transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015238	drug transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015321	sodium-dependent phosphate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015562	efflux transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0019534	toxin transporter activity; IDA:UniProtKB.
# GO_function	NPT4_HUMAN	GO 0005436 sodium phosphate symporter activity; ISS UniProtKB.
# GO_process	GO:0006814	sodium ion transport; ISS:UniProtKB.
# GO_process	GO:0006817	phosphate ion transport; ISS:UniProtKB.
# GO_process	GO:0015711	organic anion transport; IDA:UniProtKB.
# GO_process	GO:0015747	urate transport; IDA:UniProtKB.
# GO_process	GO:0015760	glucose-6-phosphate transport; TAS:UniProtKB.
# GO_process	GO:0015893	drug transport; IDA:UniProtKB.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0035725	sodium ion transmembrane transport; IBA:GO_Central.
# GO_process	GO:0046415	urate metabolic process; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	O00476	HS
# HGNC	HGNC:10931	SLC17A3
# InterPro	IPR011701	MFS
# InterPro	IPR017373	Na-dep_P-transpt_4_prd
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	611034	gene
# MIM	612671	phenotype
# Organism	NPT4_HUMAN	Homo sapiens (Human)
# PIRSF	PIRSF038072	Na(+)/PI_cotransporter4_prd
# POLYMORPHISM	Genetic variations in SLC17A3 influence the variance in serum uric acid concentrations and define the serum uric acid concentration quantitative trait locus 4 (UAQTL4) [MIM:612671]. Excess serum accumulation of uric acid can lead to the development of gout, a common disorder characterized by tissue deposition of monosodium urate crystals as a consequence of hyperuricemia. {ECO	0000269|PubMed:20810651}. 
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	NPT4_HUMAN	Sodium-dependent phosphate transport protein 4
# RefSeq	NP_001091956	NM_001098486.1. [O00476-2]
# RefSeq	NP_006623	NM_006632.3. [O00476-1]
# SEQUENCE CAUTION	Sequence=AAB53423.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	NPT4_HUMAN	Isoform 1  Endoplasmic reticulum membrane {ECO 0000269|PubMed 15505377}; Multi-pass membrane protein {ECO 0000269|PubMed 15505377}. 
# SUBCELLULAR LOCATION	NPT4_HUMAN	Isoform 2  Cell membrane {ECO 0000269|PubMed 20810651}; Multi-pass membrane protein {ECO 0000269|PubMed 20810651}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.14.28	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	NPT4_HUMAN	Expressed in the liver and kidney. It is detected in proximal tubules in renal cortex as well as some tubules and glomeruli, with highest expression at the apical side of proximal tubules (at protein level). {ECO 0000269|PubMed 20810651, ECO 0000269|PubMed 9149941}. 
# UCSC	uc003nfi	human. [O00476-1]
# eggNOG	COG0477	LUCA
# eggNOG	KOG2532	Eukaryota
BLAST	swissprot:NPT4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NPT4_HUMAN
BioCyc	ZFISH:ENSG00000124564-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000124564-MONOMER
COXPRESdb	10786	http://coxpresdb.jp/data/gene/10786.shtml
CleanEx	HS_SLC17A3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC17A3
DOI	10.1023/B:BOLI.0000045755.89308.2f	http://dx.doi.org/10.1023/B:BOLI.0000045755.89308.2f
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M110.121301	http://dx.doi.org/10.1074/jbc.M110.121301
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AK298271	http://www.ebi.ac.uk/ena/data/view/AK298271
EMBL	AL138726	http://www.ebi.ac.uk/ena/data/view/AL138726
EMBL	BC017952	http://www.ebi.ac.uk/ena/data/view/BC017952
EMBL	CH471087	http://www.ebi.ac.uk/ena/data/view/CH471087
EMBL	U90545	http://www.ebi.ac.uk/ena/data/view/U90545
Ensembl	ENST00000360657	http://www.ensembl.org/id/ENST00000360657
Ensembl	ENST00000361703	http://www.ensembl.org/id/ENST00000361703
Ensembl	ENST00000397060	http://www.ensembl.org/id/ENST00000397060
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0031526	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031526
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_function	GO:0005436	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005436
GO_function	GO:0008308	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008308
GO_function	GO:0008514	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008514
GO_function	GO:0015143	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015143
GO_function	GO:0015238	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015238
GO_function	GO:0015321	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015321
GO_function	GO:0015562	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015562
GO_function	GO:0019534	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019534
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0006817	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006817
GO_process	GO:0015711	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015711
GO_process	GO:0015747	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015747
GO_process	GO:0015760	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015760
GO_process	GO:0015893	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015893
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0035725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035725
GO_process	GO:0046415	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046415
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC17A3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC17A3
GeneID	10786	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10786
GeneTree	ENSGT00760000119079	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119079
H-InvDB	HIX0005635	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0005635
HGNC	HGNC:10931	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10931
HOGENOM	HOG000230813	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230813&db=HOGENOM6
HOVERGEN	HBG008834	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG008834&db=HOVERGEN
HPA	HPA016569	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA016569
InParanoid	O00476	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O00476
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR017373	http://www.ebi.ac.uk/interpro/entry/IPR017373
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	10786	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10786
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:10786	http://www.genome.jp/dbget-bin/www_bget?hsa:10786
KEGG_Orthology	KO:K12300	http://www.genome.jp/dbget-bin/www_bget?KO:K12300
MIM	611034	http://www.ncbi.nlm.nih.gov/omim/611034
MIM	612671	http://www.ncbi.nlm.nih.gov/omim/612671
OMA	NITMVAM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NITMVAM
OrthoDB	EOG091G077Z	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G077Z
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:NPT4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NPT4_HUMAN
PSORT-B	swissprot:NPT4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NPT4_HUMAN
PSORT2	swissprot:NPT4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NPT4_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA35822	http://www.pharmgkb.org/do/serve?objId=PA35822&objCls=Gene
Phobius	swissprot:NPT4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NPT4_HUMAN
PhylomeDB	O00476	http://phylomedb.org/?seqid=O00476
ProteinModelPortal	O00476	http://www.proteinmodelportal.org/query/uniprot/O00476
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15505377	http://www.ncbi.nlm.nih.gov/pubmed/15505377
PubMed	20810651	http://www.ncbi.nlm.nih.gov/pubmed/20810651
PubMed	9149941	http://www.ncbi.nlm.nih.gov/pubmed/9149941
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_001091956	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001091956
RefSeq	NP_006623	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006623
STRING	9606.ENSP00000380250	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000380250&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.14.28	http://www.tcdb.org/search/result.php?tc=2.A.1.14.28
UCSC	uc003nfi	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003nfi&org=rat
UniGene	Hs.327179	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.327179
UniProtKB	NPT4_HUMAN	http://www.uniprot.org/uniprot/NPT4_HUMAN
UniProtKB-AC	O00476	http://www.uniprot.org/uniprot/O00476
charge	swissprot:NPT4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NPT4_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG2532	http://eggnogapi.embl.de/nog_data/html/tree/KOG2532
epestfind	swissprot:NPT4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NPT4_HUMAN
garnier	swissprot:NPT4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NPT4_HUMAN
helixturnhelix	swissprot:NPT4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NPT4_HUMAN
hmoment	swissprot:NPT4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NPT4_HUMAN
iep	swissprot:NPT4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NPT4_HUMAN
inforesidue	swissprot:NPT4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NPT4_HUMAN
neXtProt	NX_O00476	http://www.nextprot.org/db/entry/NX_O00476
octanol	swissprot:NPT4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NPT4_HUMAN
pepcoil	swissprot:NPT4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NPT4_HUMAN
pepdigest	swissprot:NPT4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NPT4_HUMAN
pepinfo	swissprot:NPT4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NPT4_HUMAN
pepnet	swissprot:NPT4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NPT4_HUMAN
pepstats	swissprot:NPT4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NPT4_HUMAN
pepwheel	swissprot:NPT4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NPT4_HUMAN
pepwindow	swissprot:NPT4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NPT4_HUMAN
sigcleave	swissprot:NPT4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NPT4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S29A4_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7RTT9-1; Sequence=Displayed; Name=2; IsoId=Q7RTT9-2; Sequence=VSP_032647; Note=No experimental confirmation available.; 
# AltName	S29A4_HUMAN	Plasma membrane monoamine transporter
# AltName	S29A4_HUMAN	Solute carrier family 29 member 4
# CCDS	CCDS5340	-. [Q7RTT9-1]
# CCDS	CCDS75561	-. [Q7RTT9-2]
# ChiTaRS	SLC29A4	human
# DrugBank	DB00331	Metformin
# Ensembl	ENST00000297195	ENSP00000297195; ENSG00000164638. [Q7RTT9-1]
# Ensembl	ENST00000396872	ENSP00000380081; ENSG00000164638. [Q7RTT9-1]
# Ensembl	ENST00000406453	ENSP00000385845; ENSG00000164638. [Q7RTT9-2]
# ExpressionAtlas	Q7RTT9	baseline and differential
# FUNCTION	S29A4_HUMAN	Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine. In (PubMed 16873718) adenosine is efficiently transported but in a fashion highly sensitive to extracellular pH, with maximal activity in the pH range 5.5 to 6.5. Glu-206 is essential for the cation selectivity and may function as the charge sensor for cationic substrates. Transport is chloride and sodium-independent but appears to be sensitive to changes in membrane potential. Weakly inhibited by the classical inhibitors of equilibrative nucleoside transport, dipyridamole, dilazep, and nitrobenzylthioinosine. May play a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia. {ECO 0000269|PubMed 15448143, ECO 0000269|PubMed 16873718, ECO 0000269|PubMed 17018840, ECO 0000269|PubMed 17121826}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0016324	apical plasma membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0005337	nucleoside transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0008504	monoamine transmembrane transporter activity; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# Genevisible	Q7RTT9	HS
# HGNC	HGNC:23097	SLC29A4
# InterPro	IPR002259	Eqnu_transpt
# InterPro	IPR020846	MFS_dom
# InterPro	IPR030198	ENT4
# KEGG_Brite	ko02001	Solute carrier family
# MIM	609149	gene
# Organism	S29A4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10332	PTHR10332; 2
# PANTHER	PTHR10332:SF4	PTHR10332:SF4; 2
# PRINTS	PR01130	DERENTRNSPRT
# PTM	S29A4_HUMAN	N-glycosylated. {ECO 0000269|PubMed 16873718}. 
# Pfam	PF01733	Nucleoside_tran
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-83936	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
# RecName	S29A4_HUMAN	Equilibrative nucleoside transporter 4
# RefSeq	NP_001035751	NM_001040661.1. [Q7RTT9-1]
# RefSeq	NP_001287776	NM_001300847.1. [Q7RTT9-2]
# RefSeq	NP_694979	NM_153247.2. [Q7RTT9-1]
# RefSeq	XP_005249715	XM_005249658.4. [Q7RTT9-2]
# RefSeq	XP_006715730	XM_006715667.3. [Q7RTT9-1]
# RefSeq	XP_011513502	XM_011515200.2. [Q7RTT9-1]
# RefSeq	XP_011513503	XM_011515201.2. [Q7RTT9-1]
# SEQUENCE CAUTION	Sequence=BAC11612.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the SLC29A/ENT transporter (TC 2.A.57) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S29A4_HUMAN	Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. Apical cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. Note=Located to the plasma membranes of ventricular myocytes and vascular endothelial cells. Targeted to the apical membranes of differentiated kidney epithelial cells. {ECO 0000269|PubMed 15448143, ECO 0000269|PubMed 16873718}. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.57.1	the equilibrative nucleoside transporter (ent) family
# TISSUE SPECIFICITY	S29A4_HUMAN	Expressed abundantly in the heart, in both cardiomyocytes and vascular endothelial cells (at protein level). Highly expressed in brain, kidney and skeletal muscle. In the brain expressed in cerebellum, cerebral cortex, medulla, occipital pole, frontal and temporal lobes putamen and in the spinal cord. Lower expression in liver, pancreas, and liver. Expressed in endometrial tissue, exclusively in the stroma. Expression is high in the proliferative phase, decreases during the secretory phase, and is no longer detectable in the menstrual phase. {ECO 0000269|PubMed 15448143, ECO 0000269|PubMed 16873718, ECO 0000269|PubMed 17018840, ECO 0000269|PubMed 17393420}. 
# UCSC	uc003soc	human. [Q7RTT9-1]
# eggNOG	ENOG410Y3MT	LUCA
# eggNOG	KOG1479	Eukaryota
BLAST	swissprot:S29A4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S29A4_HUMAN
COXPRESdb	222962	http://coxpresdb.jp/data/gene/222962.shtml
CleanEx	HS_SLC29A4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC29A4
DOI	10.1002/mrd.20697	http://dx.doi.org/10.1002/mrd.20697
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M407913200	http://dx.doi.org/10.1074/jbc.M407913200
DOI	10.1074/jbc.M609421200	http://dx.doi.org/10.1074/jbc.M609421200
DOI	10.1093/oxfordjournals.molbev.a004044	http://dx.doi.org/10.1093/oxfordjournals.molbev.a004044
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1152/ajprenal.00302.2006	http://dx.doi.org/10.1152/ajprenal.00302.2006
DOI	10.1161/01.RES.0000238359.18495.42	http://dx.doi.org/10.1161/01.RES.0000238359.18495.42
DrugBank	DB00331	http://www.drugbank.ca/drugs/DB00331
EMBL	AK075422	http://www.ebi.ac.uk/ena/data/view/AK075422
EMBL	AK092242	http://www.ebi.ac.uk/ena/data/view/AK092242
EMBL	AY485959	http://www.ebi.ac.uk/ena/data/view/AY485959
EMBL	BC025325	http://www.ebi.ac.uk/ena/data/view/BC025325
EMBL	BC047592	http://www.ebi.ac.uk/ena/data/view/BC047592
EMBL	BK000627	http://www.ebi.ac.uk/ena/data/view/BK000627
EMBL	CH471144	http://www.ebi.ac.uk/ena/data/view/CH471144
EMBL	CH471144	http://www.ebi.ac.uk/ena/data/view/CH471144
Ensembl	ENST00000297195	http://www.ensembl.org/id/ENST00000297195
Ensembl	ENST00000396872	http://www.ensembl.org/id/ENST00000396872
Ensembl	ENST00000406453	http://www.ensembl.org/id/ENST00000406453
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_function	GO:0005337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005337
GO_function	GO:0008504	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008504
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GeneCards	SLC29A4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC29A4
GeneID	222962	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=222962
GeneTree	ENSGT00390000002232	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002232
HGNC	HGNC:23097	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:23097
HOGENOM	HOG000048076	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000048076&db=HOGENOM6
HOVERGEN	HBG095787	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG095787&db=HOVERGEN
HPA	HPA052829	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA052829
InParanoid	Q7RTT9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q7RTT9
InterPro	IPR002259	http://www.ebi.ac.uk/interpro/entry/IPR002259
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
InterPro	IPR030198	http://www.ebi.ac.uk/interpro/entry/IPR030198
Jabion	222962	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=222962
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:222962	http://www.genome.jp/dbget-bin/www_bget?hsa:222962
KEGG_Orthology	KO:K03323	http://www.genome.jp/dbget-bin/www_bget?KO:K03323
MIM	609149	http://www.ncbi.nlm.nih.gov/omim/609149
OMA	FYTTRPR	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FYTTRPR
OrthoDB	EOG091G0840	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0840
PANTHER	PTHR10332	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10332
PANTHER	PTHR10332:SF4	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10332:SF4
PRINTS	PR01130	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01130
PSORT	swissprot:S29A4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S29A4_HUMAN
PSORT-B	swissprot:S29A4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S29A4_HUMAN
PSORT2	swissprot:S29A4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S29A4_HUMAN
Pfam	PF01733	http://pfam.xfam.org/family/PF01733
PharmGKB	PA134976472	http://www.pharmgkb.org/do/serve?objId=PA134976472&objCls=Gene
Phobius	swissprot:S29A4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S29A4_HUMAN
PhylomeDB	Q7RTT9	http://phylomedb.org/?seqid=Q7RTT9
ProteinModelPortal	Q7RTT9	http://www.proteinmodelportal.org/query/uniprot/Q7RTT9
PubMed	12446811	http://www.ncbi.nlm.nih.gov/pubmed/12446811
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15448143	http://www.ncbi.nlm.nih.gov/pubmed/15448143
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16873718	http://www.ncbi.nlm.nih.gov/pubmed/16873718
PubMed	17018840	http://www.ncbi.nlm.nih.gov/pubmed/17018840
PubMed	17121826	http://www.ncbi.nlm.nih.gov/pubmed/17121826
PubMed	17393420	http://www.ncbi.nlm.nih.gov/pubmed/17393420
Reactome	R-HSA-83936	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-83936
RefSeq	NP_001035751	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001035751
RefSeq	NP_001287776	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001287776
RefSeq	NP_694979	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_694979
RefSeq	XP_005249715	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005249715
RefSeq	XP_006715730	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006715730
RefSeq	XP_011513502	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011513502
RefSeq	XP_011513503	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011513503
STRING	9606.ENSP00000297195	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000297195&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.57.1	http://www.tcdb.org/search/result.php?tc=2.A.57.1
UCSC	uc003soc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003soc&org=rat
UniGene	Hs.4302	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.4302
UniProtKB	S29A4_HUMAN	http://www.uniprot.org/uniprot/S29A4_HUMAN
UniProtKB-AC	Q7RTT9	http://www.uniprot.org/uniprot/Q7RTT9
charge	swissprot:S29A4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S29A4_HUMAN
eggNOG	ENOG410Y3MT	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y3MT
eggNOG	KOG1479	http://eggnogapi.embl.de/nog_data/html/tree/KOG1479
epestfind	swissprot:S29A4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S29A4_HUMAN
garnier	swissprot:S29A4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S29A4_HUMAN
helixturnhelix	swissprot:S29A4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S29A4_HUMAN
hmoment	swissprot:S29A4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S29A4_HUMAN
iep	swissprot:S29A4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S29A4_HUMAN
inforesidue	swissprot:S29A4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S29A4_HUMAN
neXtProt	NX_Q7RTT9	http://www.nextprot.org/db/entry/NX_Q7RTT9
octanol	swissprot:S29A4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S29A4_HUMAN
pepcoil	swissprot:S29A4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S29A4_HUMAN
pepdigest	swissprot:S29A4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S29A4_HUMAN
pepinfo	swissprot:S29A4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S29A4_HUMAN
pepnet	swissprot:S29A4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S29A4_HUMAN
pepstats	swissprot:S29A4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S29A4_HUMAN
pepwheel	swissprot:S29A4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S29A4_HUMAN
pepwindow	swissprot:S29A4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S29A4_HUMAN
sigcleave	swissprot:S29A4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S29A4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GBRR2_HUMAN	Event=Alternative initiation; Named isoforms=2; Name=1; IsoId=P28476-1; Sequence=Displayed; Name=2; IsoId=P28476-2; Sequence=VSP_044373; Note=Isoform 2 could be translated from an upstream initiator ATG located in frame within the first coding exon. The probability of a signal peptide within this isoform is very low. No experimental confirmation available.; 
# AltName	GBRR2_HUMAN	GABA(A) receptor subunit rho-2
# AltName	GBRR2_HUMAN	GABA(C) receptor
# CCDS	CCDS5020	-. [P28476-1]
# ChiTaRS	GABRR2	human
# DrugBank	DB00231	Temazepam
# DrugBank	DB00546	Adinazolam
# DrugBank	DB00683	Midazolam
# DrugBank	DB00690	Flurazepam
# DrugBank	DB00801	Halazepam
# DrugBank	DB00829	Diazepam
# DrugBank	DB00842	Oxazepam
# DrugBank	DB00897	Triazolam
# DrugBank	DB01215	Estazolam
# DrugBank	DB01558	Bromazepam
# DrugBank	DB01559	Clotiazepam
# DrugBank	DB01567	Fludiazepam
# DrugBank	DB01588	Prazepam
# DrugBank	DB01589	Quazepam
# DrugBank	DB01594	Cinolazepam
# DrugBank	DB01595	Nitrazepam
# Ensembl	ENST00000402938	ENSP00000386029; ENSG00000111886. [P28476-1]
# FUNCTION	GBRR2_HUMAN	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:1902711	GABA-A receptor complex; IBA:GO_Central.
# GO_function	GO:0004890	GABA-A receptor activity; TAS:ProtInc.
# GO_function	GO:0005230	extracellular ligand-gated ion channel activity; IEA:InterPro.
# GO_function	GO:0005254	chloride channel activity; IEA:UniProtKB-KW.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0007214	gamma-aminobutyric acid signaling pathway; IEA:Ensembl.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:ProtInc.
# GO_process	GO:0007601	visual perception; IEA:Ensembl.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.70.170.10	-; 1.
# Genevisible	P28476	HS
# HGNC	HGNC:4091	GABRR2
# InterPro	IPR006028	GABAA/Glycine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR008057	GABAAa_rho_rcpt
# InterPro	IPR008059	GABAAa_rho2_rcpt
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04727	GABAergic synapse
# KEGG_Pathway	ko05032	Morphine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# MIM	137162	gene
# Organism	GBRR2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR18945	PTHR18945
# PIR	A38079	A38079
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00253	GABAARECEPTR
# PRINTS	PR01670	GABAARRHO
# PRINTS	PR01672	GABAARRHO2
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-975298	Ligand-gated ion channel transport
# Reactome	R-HSA-977442	GABA A (rho) receptor activation
# RecName	GBRR2_HUMAN	Gamma-aminobutyric acid receptor subunit rho-2
# RefSeq	NP_002034	NM_002043.4. [P28476-1]
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR2 sub-subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	GBRR2_HUMAN	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1 (By similarity). {ECO	0000250}. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TIGRFAMs	TIGR00860	LIC
# UCSC	uc003pnb	human. [P28476-1]
# eggNOG	ENOG410XPWH	LUCA
# eggNOG	KOG3643	Eukaryota
BLAST	swissprot:GBRR2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GBRR2_HUMAN
BioCyc	ZFISH:ENSG00000111886-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000111886-MONOMER
COXPRESdb	2570	http://coxpresdb.jp/data/gene/2570.shtml
DOI	10.1016/0888-7543(92)90312-G	http://dx.doi.org/10.1016/0888-7543(92)90312-G
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00231	http://www.drugbank.ca/drugs/DB00231
DrugBank	DB00546	http://www.drugbank.ca/drugs/DB00546
DrugBank	DB00683	http://www.drugbank.ca/drugs/DB00683
DrugBank	DB00690	http://www.drugbank.ca/drugs/DB00690
DrugBank	DB00801	http://www.drugbank.ca/drugs/DB00801
DrugBank	DB00829	http://www.drugbank.ca/drugs/DB00829
DrugBank	DB00842	http://www.drugbank.ca/drugs/DB00842
DrugBank	DB00897	http://www.drugbank.ca/drugs/DB00897
DrugBank	DB01215	http://www.drugbank.ca/drugs/DB01215
DrugBank	DB01558	http://www.drugbank.ca/drugs/DB01558
DrugBank	DB01559	http://www.drugbank.ca/drugs/DB01559
DrugBank	DB01567	http://www.drugbank.ca/drugs/DB01567
DrugBank	DB01588	http://www.drugbank.ca/drugs/DB01588
DrugBank	DB01589	http://www.drugbank.ca/drugs/DB01589
DrugBank	DB01594	http://www.drugbank.ca/drugs/DB01594
DrugBank	DB01595	http://www.drugbank.ca/drugs/DB01595
EMBL	AL121833	http://www.ebi.ac.uk/ena/data/view/AL121833
EMBL	BC130352	http://www.ebi.ac.uk/ena/data/view/BC130352
EMBL	BC130354	http://www.ebi.ac.uk/ena/data/view/BC130354
EMBL	M86868	http://www.ebi.ac.uk/ena/data/view/M86868
Ensembl	ENST00000402938	http://www.ensembl.org/id/ENST00000402938
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_component	GO:1902711	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902711
GO_function	GO:0004890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004890
GO_function	GO:0005230	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005230
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007214	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007214
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007601	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007601
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	GABRR2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GABRR2
GeneID	2570	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2570
GeneTree	ENSGT00760000118821	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118821
H-InvDB	HIX0200918	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0200918
HGNC	HGNC:4091	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4091
HOGENOM	HOG000231335	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231335&db=HOGENOM6
HOVERGEN	HBG051707	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051707&db=HOVERGEN
HPA	HPA016467	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA016467
InParanoid	P28476	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P28476
InterPro	IPR006028	http://www.ebi.ac.uk/interpro/entry/IPR006028
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR008057	http://www.ebi.ac.uk/interpro/entry/IPR008057
InterPro	IPR008059	http://www.ebi.ac.uk/interpro/entry/IPR008059
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
Jabion	2570	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2570
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:2570	http://www.genome.jp/dbget-bin/www_bget?hsa:2570
KEGG_Orthology	KO:K05190	http://www.genome.jp/dbget-bin/www_bget?KO:K05190
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
KEGG_Pathway	ko05032	http://www.genome.jp/kegg-bin/show_pathway?ko05032
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
MIM	137162	http://www.ncbi.nlm.nih.gov/omim/137162
OMA	DFSMRPA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DFSMRPA
OrthoDB	EOG091G0805	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0805
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00253	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00253
PRINTS	PR01670	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01670
PRINTS	PR01672	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01672
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:GBRR2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GBRR2_HUMAN
PSORT-B	swissprot:GBRR2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GBRR2_HUMAN
PSORT2	swissprot:GBRR2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GBRR2_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA28506	http://www.pharmgkb.org/do/serve?objId=PA28506&objCls=Gene
Phobius	swissprot:GBRR2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GBRR2_HUMAN
ProteinModelPortal	P28476	http://www.proteinmodelportal.org/query/uniprot/P28476
PubMed	1315307	http://www.ncbi.nlm.nih.gov/pubmed/1315307
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-975298	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-975298
Reactome	R-HSA-977442	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-977442
RefSeq	NP_002034	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002034
SMR	P28476	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P28476
STRING	9606.ENSP00000386029	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000386029&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc003pnb	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003pnb&org=rat
UniGene	Hs.379330	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.379330
UniGene	Hs.719891	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.719891
UniProtKB	GBRR2_HUMAN	http://www.uniprot.org/uniprot/GBRR2_HUMAN
UniProtKB-AC	P28476	http://www.uniprot.org/uniprot/P28476
charge	swissprot:GBRR2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GBRR2_HUMAN
eggNOG	ENOG410XPWH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPWH
eggNOG	KOG3643	http://eggnogapi.embl.de/nog_data/html/tree/KOG3643
epestfind	swissprot:GBRR2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GBRR2_HUMAN
garnier	swissprot:GBRR2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GBRR2_HUMAN
helixturnhelix	swissprot:GBRR2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GBRR2_HUMAN
hmoment	swissprot:GBRR2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GBRR2_HUMAN
iep	swissprot:GBRR2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GBRR2_HUMAN
inforesidue	swissprot:GBRR2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GBRR2_HUMAN
neXtProt	NX_P28476	http://www.nextprot.org/db/entry/NX_P28476
octanol	swissprot:GBRR2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GBRR2_HUMAN
pepcoil	swissprot:GBRR2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GBRR2_HUMAN
pepdigest	swissprot:GBRR2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GBRR2_HUMAN
pepinfo	swissprot:GBRR2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GBRR2_HUMAN
pepnet	swissprot:GBRR2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GBRR2_HUMAN
pepstats	swissprot:GBRR2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GBRR2_HUMAN
pepwheel	swissprot:GBRR2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GBRR2_HUMAN
pepwindow	swissprot:GBRR2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GBRR2_HUMAN
sigcleave	swissprot:GBRR2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GBRR2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	VMAT2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q05940-1; Sequence=Displayed; Name=2; IsoId=Q05940-2; Sequence=VSP_057151, VSP_057152; Note=No experimental confirmation available.; 
# AltName	VMAT2_HUMAN	Monoamine transporter
# AltName	VMAT2_HUMAN	Solute carrier family 18 member 2
# AltName	VMAT2_HUMAN	Vesicular amine transporter 2
# CCDS	CCDS7599	-. [Q05940-1]
# CDD	cd06174	MFS
# DrugBank	DB00182	Amphetamine
# DrugBank	DB00206	Reserpine
# DrugBank	DB00368	Norepinephrine
# DrugBank	DB00865	Benzphetamine
# DrugBank	DB01089	Deserpidine
# DrugBank	DB01363	Ephedra
# DrugBank	DB01364	Ephedrine
# DrugBank	DB01576	Dextroamphetamine
# DrugBank	DB01577	Methamphetamine
# DrugBank	DB04844	Tetrabenazine
# DrugBank	DB06706	Isometheptene
# DrugBank	DB06714	Propylhexedrine
# Ensembl	ENST00000298472	ENSP00000298472; ENSG00000165646. [Q05940-1]
# FUNCTION	VMAT2_HUMAN	Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0008021	synaptic vesicle; TAS:ParkinsonsUK-UCL.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0030672	synaptic vesicle membrane; IBA:GO_Central.
# GO_component	GO:0043195	terminal bouton; IBA:GO_Central.
# GO_component	GO:0070083	clathrin-sculpted monoamine transport vesicle membrane; TAS:Reactome.
# GO_function	GO:0008504	monoamine transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015222	serotonin transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0001975	response to amphetamine; IEA:Ensembl.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:ParkinsonsUK-UCL.
# GO_process	GO:0007269	neurotransmitter secretion; TAS:Reactome.
# GO_process	GO:0007626	locomotory behavior; IEA:Ensembl.
# GO_process	GO:0009636	response to toxic substance; IEA:Ensembl.
# GO_process	GO:0009791	post-embryonic development; IEA:Ensembl.
# GO_process	GO:0015842	aminergic neurotransmitter loading into synaptic vesicle; IBA:GO_Central.
# GO_process	GO:0015844	monoamine transport; TAS:ProtInc.
# GO_process	GO:0015872	dopamine transport; TAS:ParkinsonsUK-UCL.
# GO_process	GO:0042137	sequestering of neurotransmitter; NAS:ParkinsonsUK-UCL.
# GO_process	GO:0098700	neurotransmitter loading into synaptic vesicle; TAS:ParkinsonsUK-UCL.
# GO_process	GO:1903427	negative regulation of reactive oxygen species biosynthetic process; NAS:ParkinsonsUK-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q05940	HS
# HGNC	HGNC:10935	SLC18A2
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04726	Serotonergic synapse
# KEGG_Pathway	ko04728	Dopaminergic synapse
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05030	Cocaine addiction
# KEGG_Pathway	ko05031	Amphetamine addiction
# KEGG_Pathway	ko05034	Alcoholism
# MIM	193001	gene
# Organism	VMAT2_HUMAN	Homo sapiens (Human)
# Orphanet	352649	Brain dopamine-serotonin vesicular transport disease
# PIR	A49368	A49368
# PIR	S29810	S29810
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 10
# Reactome	R-HSA-181429	Serotonin Neurotransmitter Release Cycle
# Reactome	R-HSA-181430	Norepinephrine Neurotransmitter Release Cycle
# Reactome	R-HSA-212676	Dopamine Neurotransmitter Release Cycle
# Reactome	R-HSA-442660	Na+/Cl- dependent neurotransmitter transporters
# RecName	VMAT2_HUMAN	Synaptic vesicular amine transporter
# RefSeq	NP_003045	NM_003054.4. [Q05940-1]
# SEQUENCE CAUTION	Sequence=BAB19009.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the major facilitator superfamily. Vesicular transporter family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	VMAT2_HUMAN	Cytoplasmic vesicle membrane; Multi-pass membrane protein. 
# SUBUNIT	Interacts with SLC6A3. {ECO	0000250}. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.1.2.29	the major facilitator superfamily (mfs)
# UCSC	uc001ldd	human. [Q05940-1]
# WEB RESOURCE	VMAT2_HUMAN	Name=Wikipedia; Note=Vesicular monoamine transporter entry; URL="https //en.wikipedia.org/wiki/Vesicular_monoamine_transporter";
# eggNOG	ENOG410XW69	LUCA
# eggNOG	KOG3764	Eukaryota
BLAST	swissprot:VMAT2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VMAT2_HUMAN
BioCyc	ZFISH:ENSG00000165646-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000165646-MONOMER
COXPRESdb	6571	http://coxpresdb.jp/data/gene/6571.shtml
CleanEx	HS_SLC18A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC18A2
DOI	10.1007/BF01244941	http://dx.doi.org/10.1007/BF01244941
DOI	10.1016/0014-5793(93)80539-7	http://dx.doi.org/10.1016/0014-5793(93)80539-7
DOI	10.1016/S0888-7543(05)80383-0	http://dx.doi.org/10.1016/S0888-7543(05)80383-0
DOI	10.1021/bi015779j	http://dx.doi.org/10.1021/bi015779j
DOI	10.1021/pr0704130	http://dx.doi.org/10.1021/pr0704130
DOI	10.1038/nature02462	http://dx.doi.org/10.1038/nature02462
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1038/sj.mp.4000895	http://dx.doi.org/10.1038/sj.mp.4000895
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1471-4159.1993.tb07476.x	http://dx.doi.org/10.1111/j.1471-4159.1993.tb07476.x
DrugBank	DB00182	http://www.drugbank.ca/drugs/DB00182
DrugBank	DB00206	http://www.drugbank.ca/drugs/DB00206
DrugBank	DB00368	http://www.drugbank.ca/drugs/DB00368
DrugBank	DB00865	http://www.drugbank.ca/drugs/DB00865
DrugBank	DB01089	http://www.drugbank.ca/drugs/DB01089
DrugBank	DB01363	http://www.drugbank.ca/drugs/DB01363
DrugBank	DB01364	http://www.drugbank.ca/drugs/DB01364
DrugBank	DB01576	http://www.drugbank.ca/drugs/DB01576
DrugBank	DB01577	http://www.drugbank.ca/drugs/DB01577
DrugBank	DB04844	http://www.drugbank.ca/drugs/DB04844
DrugBank	DB06706	http://www.drugbank.ca/drugs/DB06706
DrugBank	DB06714	http://www.drugbank.ca/drugs/DB06714
EMBL	AB044401	http://www.ebi.ac.uk/ena/data/view/AB044401
EMBL	AK314997	http://www.ebi.ac.uk/ena/data/view/AK314997
EMBL	AL391988	http://www.ebi.ac.uk/ena/data/view/AL391988
EMBL	AL391988	http://www.ebi.ac.uk/ena/data/view/AL391988
EMBL	AL731557	http://www.ebi.ac.uk/ena/data/view/AL731557
EMBL	AL731557	http://www.ebi.ac.uk/ena/data/view/AL731557
EMBL	BC030593	http://www.ebi.ac.uk/ena/data/view/BC030593
EMBL	BC108927	http://www.ebi.ac.uk/ena/data/view/BC108927
EMBL	BC108928	http://www.ebi.ac.uk/ena/data/view/BC108928
EMBL	CH471066	http://www.ebi.ac.uk/ena/data/view/CH471066
EMBL	CH471066	http://www.ebi.ac.uk/ena/data/view/CH471066
EMBL	L09118	http://www.ebi.ac.uk/ena/data/view/L09118
EMBL	L14269	http://www.ebi.ac.uk/ena/data/view/L14269
EMBL	L23205	http://www.ebi.ac.uk/ena/data/view/L23205
EMBL	X71354	http://www.ebi.ac.uk/ena/data/view/X71354
Ensembl	ENST00000298472	http://www.ensembl.org/id/ENST00000298472
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0008021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008021
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0030672	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030672
GO_component	GO:0043195	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043195
GO_component	GO:0070083	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070083
GO_function	GO:0008504	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008504
GO_function	GO:0015222	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015222
GO_process	GO:0001975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001975
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007269	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007269
GO_process	GO:0007626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007626
GO_process	GO:0009636	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009636
GO_process	GO:0009791	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009791
GO_process	GO:0015842	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015842
GO_process	GO:0015844	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015844
GO_process	GO:0015872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015872
GO_process	GO:0042137	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042137
GO_process	GO:0098700	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098700
GO_process	GO:1903427	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903427
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	SLC18A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC18A2
GeneID	6571	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6571
GeneTree	ENSGT00390000003851	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000003851
H-InvDB	HIX0035636	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0035636
HGNC	HGNC:10935	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10935
HOGENOM	HOG000018545	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000018545&db=HOGENOM6
HOVERGEN	HBG055082	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG055082&db=HOVERGEN
HPA	HPA016856	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA016856
InParanoid	Q05940	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q05940
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	6571	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6571
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6571	http://www.genome.jp/dbget-bin/www_bget?hsa:6571
KEGG_Orthology	KO:K08155	http://www.genome.jp/dbget-bin/www_bget?KO:K08155
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04726	http://www.genome.jp/kegg-bin/show_pathway?ko04726
KEGG_Pathway	ko04728	http://www.genome.jp/kegg-bin/show_pathway?ko04728
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05030	http://www.genome.jp/kegg-bin/show_pathway?ko05030
KEGG_Pathway	ko05031	http://www.genome.jp/kegg-bin/show_pathway?ko05031
KEGG_Pathway	ko05034	http://www.genome.jp/kegg-bin/show_pathway?ko05034
MIM	193001	http://www.ncbi.nlm.nih.gov/omim/193001
OMA	QKAETEP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QKAETEP
Orphanet	352649	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=352649
OrthoDB	EOG091G0534	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0534
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:VMAT2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VMAT2_HUMAN
PSORT-B	swissprot:VMAT2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VMAT2_HUMAN
PSORT2	swissprot:VMAT2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VMAT2_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA325	http://www.pharmgkb.org/do/serve?objId=PA325&objCls=Gene
Phobius	swissprot:VMAT2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VMAT2_HUMAN
PhylomeDB	Q05940	http://phylomedb.org/?seqid=Q05940
ProteinModelPortal	Q05940	http://www.proteinmodelportal.org/query/uniprot/Q05940
PubMed	11443533	http://www.ncbi.nlm.nih.gov/pubmed/11443533
PubMed	12009896	http://www.ncbi.nlm.nih.gov/pubmed/12009896
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15164054	http://www.ncbi.nlm.nih.gov/pubmed/15164054
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18088087	http://www.ncbi.nlm.nih.gov/pubmed/18088087
PubMed	7905859	http://www.ncbi.nlm.nih.gov/pubmed/7905859
PubMed	8095030	http://www.ncbi.nlm.nih.gov/pubmed/8095030
PubMed	8245983	http://www.ncbi.nlm.nih.gov/pubmed/8245983
PubMed	8373557	http://www.ncbi.nlm.nih.gov/pubmed/8373557
Reactome	R-HSA-181429	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-181429
Reactome	R-HSA-181430	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-181430
Reactome	R-HSA-212676	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-212676
Reactome	R-HSA-442660	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442660
RefSeq	NP_003045	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003045
STRING	9606.ENSP00000298472	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000298472&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.2.29	http://www.tcdb.org/search/result.php?tc=2.A.1.2.29
UCSC	uc001ldd	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001ldd&org=rat
UniGene	Hs.596992	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.596992
UniProtKB	VMAT2_HUMAN	http://www.uniprot.org/uniprot/VMAT2_HUMAN
UniProtKB-AC	Q05940	http://www.uniprot.org/uniprot/Q05940
charge	swissprot:VMAT2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VMAT2_HUMAN
eggNOG	ENOG410XW69	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XW69
eggNOG	KOG3764	http://eggnogapi.embl.de/nog_data/html/tree/KOG3764
epestfind	swissprot:VMAT2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VMAT2_HUMAN
garnier	swissprot:VMAT2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VMAT2_HUMAN
helixturnhelix	swissprot:VMAT2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VMAT2_HUMAN
hmoment	swissprot:VMAT2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VMAT2_HUMAN
iep	swissprot:VMAT2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VMAT2_HUMAN
inforesidue	swissprot:VMAT2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VMAT2_HUMAN
neXtProt	NX_Q05940	http://www.nextprot.org/db/entry/NX_Q05940
octanol	swissprot:VMAT2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VMAT2_HUMAN
pepcoil	swissprot:VMAT2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VMAT2_HUMAN
pepdigest	swissprot:VMAT2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VMAT2_HUMAN
pepinfo	swissprot:VMAT2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VMAT2_HUMAN
pepnet	swissprot:VMAT2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VMAT2_HUMAN
pepstats	swissprot:VMAT2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VMAT2_HUMAN
pepwheel	swissprot:VMAT2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VMAT2_HUMAN
pepwindow	swissprot:VMAT2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VMAT2_HUMAN
sigcleave	swissprot:VMAT2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VMAT2_HUMAN
## Database	ID	URL or Descriptions
# AltName	S7A14_HUMAN	Solute carrier family 7 member 14
# DISEASE	S7A14_HUMAN	Retinitis pigmentosa 68 (RP68) [MIM 615725]  A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. {ECO 0000269|PubMed 24670872}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000231706	ENSP00000231706; ENSG00000013293
# FUNCTION	S7A14_HUMAN	May be involved in arginine transport. {ECO 0000269|PubMed 22787143, ECO 0000269|PubMed 24670872}. 
# GO_component	GO:0005765	lysosomal membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0015179	L-amino acid transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015297	antiporter activity; IBA:GO_Central.
# GO_process	GO:0010923	negative regulation of phosphatase activity; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q8TBB6	HS
# HGNC	HGNC:29326	SLC7A14
# IntAct	Q8TBB6	2
# InterPro	IPR002293	AA/rel_permease1
# InterPro	IPR029485	CAT_C
# KEGG_Brite	ko02001	Solute carrier family
# MIM	615720	gene
# MIM	615725	phenotype
# Organism	S7A14_HUMAN	Homo sapiens (Human)
# Orphanet	791	Retinitis pigmentosa
# PANTHER	PTHR11785	PTHR11785; 2
# Pfam	PF13520	AA_permease_2
# Pfam	PF13906	AA_permease_C
# Proteomes	UP000005640	Chromosome 3
# RecName	S7A14_HUMAN	Probable cationic amino acid transporter
# RefSeq	NP_066000	NM_020949.2
# SEQUENCE CAUTION	Sequence=BAB13439.1; Type=Erroneous termination; Positions=765; Note=Translated as Glu.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S7A14_HUMAN	Lysosome membrane {ECO 0000269|PubMed 22787143, ECO 0000269|PubMed 24670872}; Multi- pass membrane protein {ECO 0000269|PubMed 22787143, ECO 0000269|PubMed 24670872}. Note=Exhibits a punctated pattern in the cytoplasm, which partially ovelaps with lysosomes. 
# TCDB	2.A.3.3	the amino acid-polyamine-organocation (apc) family
# TISSUE SPECIFICITY	Expressed in skin fibroblasts. {ECO:0000269|PubMed	22787143}. 
# UCSC	uc003fgz	human
# eggNOG	COG0531	LUCA
# eggNOG	KOG1286	Eukaryota
BLAST	swissprot:S7A14_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S7A14_HUMAN
BioCyc	ZFISH:ENSG00000013293-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000013293-MONOMER
COXPRESdb	57709	http://coxpresdb.jp/data/gene/57709.shtml
CleanEx	HS_SLC7A14	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC7A14
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1038/ncomms4517	http://dx.doi.org/10.1038/ncomms4517
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M112.350322	http://dx.doi.org/10.1074/jbc.M112.350322
DOI	10.1093/dnares/7.4.271	http://dx.doi.org/10.1093/dnares/7.4.271
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB046833	http://www.ebi.ac.uk/ena/data/view/AB046833
EMBL	AC008041	http://www.ebi.ac.uk/ena/data/view/AC008041
EMBL	AK122655	http://www.ebi.ac.uk/ena/data/view/AK122655
EMBL	BC022968	http://www.ebi.ac.uk/ena/data/view/BC022968
Ensembl	ENST00000231706	http://www.ensembl.org/id/ENST00000231706
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0015179	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015179
GO_function	GO:0015297	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297
GO_process	GO:0010923	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010923
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	SLC7A14	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC7A14
GeneID	57709	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57709
GeneTree	ENSGT00760000119151	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119151
HGNC	HGNC:29326	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:29326
HOGENOM	HOG000250623	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000250623&db=HOGENOM6
HOVERGEN	HBG000280	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000280&db=HOVERGEN
HPA	HPA045929	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA045929
InParanoid	Q8TBB6	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8TBB6
IntAct	Q8TBB6	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8TBB6*
InterPro	IPR002293	http://www.ebi.ac.uk/interpro/entry/IPR002293
InterPro	IPR029485	http://www.ebi.ac.uk/interpro/entry/IPR029485
Jabion	57709	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=57709
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:57709	http://www.genome.jp/dbget-bin/www_bget?hsa:57709
KEGG_Orthology	KO:K13871	http://www.genome.jp/dbget-bin/www_bget?KO:K13871
MIM	615720	http://www.ncbi.nlm.nih.gov/omim/615720
MIM	615725	http://www.ncbi.nlm.nih.gov/omim/615725
OMA	ESQENWG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ESQENWG
Orphanet	791	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=791
OrthoDB	EOG091G05NM	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05NM
PANTHER	PTHR11785	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785
PSORT	swissprot:S7A14_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S7A14_HUMAN
PSORT-B	swissprot:S7A14_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S7A14_HUMAN
PSORT2	swissprot:S7A14_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S7A14_HUMAN
Pfam	PF13520	http://pfam.xfam.org/family/PF13520
Pfam	PF13906	http://pfam.xfam.org/family/PF13906
PharmGKB	PA142670913	http://www.pharmgkb.org/do/serve?objId=PA142670913&objCls=Gene
Phobius	swissprot:S7A14_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S7A14_HUMAN
PhylomeDB	Q8TBB6	http://phylomedb.org/?seqid=Q8TBB6
ProteinModelPortal	Q8TBB6	http://www.proteinmodelportal.org/query/uniprot/Q8TBB6
PubMed	10997877	http://www.ncbi.nlm.nih.gov/pubmed/10997877
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	22787143	http://www.ncbi.nlm.nih.gov/pubmed/22787143
PubMed	24670872	http://www.ncbi.nlm.nih.gov/pubmed/24670872
RefSeq	NP_066000	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_066000
STRING	9606.ENSP00000231706	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000231706&targetmode=cogs
TCDB	2.A.3.3	http://www.tcdb.org/search/result.php?tc=2.A.3.3
UCSC	uc003fgz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003fgz&org=rat
UniGene	Hs.596660	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.596660
UniProtKB	S7A14_HUMAN	http://www.uniprot.org/uniprot/S7A14_HUMAN
UniProtKB-AC	Q8TBB6	http://www.uniprot.org/uniprot/Q8TBB6
charge	swissprot:S7A14_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S7A14_HUMAN
eggNOG	COG0531	http://eggnogapi.embl.de/nog_data/html/tree/COG0531
eggNOG	KOG1286	http://eggnogapi.embl.de/nog_data/html/tree/KOG1286
epestfind	swissprot:S7A14_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S7A14_HUMAN
garnier	swissprot:S7A14_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S7A14_HUMAN
helixturnhelix	swissprot:S7A14_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S7A14_HUMAN
hmoment	swissprot:S7A14_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S7A14_HUMAN
iep	swissprot:S7A14_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S7A14_HUMAN
inforesidue	swissprot:S7A14_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S7A14_HUMAN
neXtProt	NX_Q8TBB6	http://www.nextprot.org/db/entry/NX_Q8TBB6
octanol	swissprot:S7A14_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S7A14_HUMAN
pepcoil	swissprot:S7A14_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S7A14_HUMAN
pepdigest	swissprot:S7A14_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S7A14_HUMAN
pepinfo	swissprot:S7A14_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S7A14_HUMAN
pepnet	swissprot:S7A14_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S7A14_HUMAN
pepstats	swissprot:S7A14_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S7A14_HUMAN
pepwheel	swissprot:S7A14_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S7A14_HUMAN
pepwindow	swissprot:S7A14_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S7A14_HUMAN
sigcleave	swissprot:S7A14_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S7A14_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S47A2_HUMAN	Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q86VL8-1; Sequence=Displayed; Name=2; IsoId=Q86VL8-2; Sequence=VSP_029656, VSP_029658, VSP_029663, VSP_029664; Note=No experimental confirmation available.; Name=3; Synonyms=MATE2-K; IsoId=Q86VL8-3; Sequence=VSP_029658; Note=No experimental confirmation available.; Name=4; IsoId=Q86VL8-4; Sequence=VSP_029658, VSP_029662; Note=No experimental confirmation available.; Name=5; IsoId=Q86VL8-5; Sequence=VSP_029658, VSP_029660, VSP_029661; Note=No experimental confirmation available.; Name=6; Synonyms=MATE2-B; IsoId=Q86VL8-6; Sequence=VSP_029657, VSP_029659; Note=Inactive. Note=No experimental confirmation available.; 
# AltName	S47A2_HUMAN	Kidney-specific H(+)/organic cation antiporter
# AltName	S47A2_HUMAN	Solute carrier family 47 member 2
# BIOPHYSICOCHEMICAL PROPERTIES	S47A2_HUMAN	Kinetic parameters  KM=0.76 mM for TEA {ECO 0000269|PubMed 16807400, ECO 0000269|PubMed 17509534}; KM=0.11 mM for MPP {ECO 0000269|PubMed 16807400, ECO 0000269|PubMed 17509534}; KM=0.12 mM for cimetidine {ECO 0000269|PubMed 16807400, ECO 0000269|PubMed 17509534}; KM=1.98 mM for metformin {ECO 0000269|PubMed 16807400, ECO 0000269|PubMed 17509534}; KM=4.2 mM for guanidine {ECO 0000269|PubMed 16807400, ECO 0000269|PubMed 17509534}; KM=1.58 mM for procainamide {ECO 0000269|PubMed 16807400, ECO 0000269|PubMed 17509534}; KM=0.06 mM for topotecan {ECO 0000269|PubMed 16807400, ECO 0000269|PubMed 17509534}; KM=0.85 mM for estrone sulfate {ECO 0000269|PubMed 16807400, ECO 0000269|PubMed 17509534}; KM=4.32 mM for acyclovir {ECO 0000269|PubMed 16807400, ECO 0000269|PubMed 17509534}; KM=4.28 mM for ganciclovir {ECO 0000269|PubMed 16807400, ECO 0000269|PubMed 17509534}; Vmax=0.88 nmol/min/mg enzyme toward TEA {ECO 0000269|PubMed 16807400, ECO 0000269|PubMed 17509534}; Vmax=0.575 nmol/min/mg enzyme toward MPP {ECO 0000269|PubMed 16807400, ECO 0000269|PubMed 17509534}; Vmax=0.115 nmol/min/mg enzyme toward cimetidine {ECO 0000269|PubMed 16807400, ECO 0000269|PubMed 17509534}; Vmax=0.845 nmol/min/mg enzyme toward metformin {ECO 0000269|PubMed 16807400, ECO 0000269|PubMed 17509534}; Vmax=0.58 nmol/min/mg enzyme toward guanidine {ECO 0000269|PubMed 16807400, ECO 0000269|PubMed 17509534}; Vmax=3.385 nmol/min/mg enzyme toward procainamide {ECO 0000269|PubMed 16807400, ECO 0000269|PubMed 17509534}; Vmax=0.13 nmol/min/mg enzyme toward topotecan {ECO 0000269|PubMed 16807400, ECO 0000269|PubMed 17509534}; Vmax=0.425 nmol/min/mg enzyme toward estrone sulfate {ECO 0000269|PubMed 16807400, ECO 0000269|PubMed 17509534}; Vmax=0.945 nmol/min/mg enzyme toward acyclovir {ECO 0000269|PubMed 16807400, ECO 0000269|PubMed 17509534}; Vmax=0.805 nmol/min/mg enzyme toward ganciclovir {ECO 0000269|PubMed 16807400, ECO 0000269|PubMed 17509534}; pH dependence  Optimum pH is 9.0. Active from pH 6 to 9. {ECO 0000269|PubMed 16807400, ECO 0000269|PubMed 17509534}; 
# CCDS	CCDS11211	-. [Q86VL8-1]
# CCDS	CCDS58530	-. [Q86VL8-4]
# DrugBank	DB00787	Aciclovir
# Ensembl	ENST00000325411	ENSP00000326671; ENSG00000180638. [Q86VL8-1]
# Ensembl	ENST00000350657	ENSP00000338084; ENSG00000180638. [Q86VL8-4]
# Ensembl	ENST00000574239	ENSP00000458694; ENSG00000180638. [Q86VL8-6]
# ExpressionAtlas	Q86VL8	baseline and differential
# FUNCTION	S47A2_HUMAN	Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes. {ECO 0000269|PubMed 16807400, ECO 0000269|PubMed 16996621, ECO 0000269|PubMed 17509534}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015238	drug transmembrane transporter activity; IBA:GO_Central.
# GO_function	S47A2_HUMAN	GO 0015307 drug proton antiporter activity; TAS Reactome.
# GO_process	GO:0006855	drug transmembrane transport; IBA:GO_Central.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q86VL8	HS
# HGNC	HGNC:26439	SLC47A2
# InterPro	IPR002528	MATE_fam
# KEGG_Brite	ko02001	Solute carrier family
# MIM	609833	gene
# Organism	S47A2_HUMAN	Homo sapiens (Human)
# Pfam	PF01554	MatE; 2
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-425366	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
# RecName	S47A2_HUMAN	Multidrug and toxin extrusion protein 2
# RefSeq	NP_001093116	NM_001099646.1. [Q86VL8-3]
# RefSeq	NP_001243592	NM_001256663.1. [Q86VL8-4]
# RefSeq	NP_690872	NM_152908.3. [Q86VL8-1]
# SIMILARITY	Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S47A2_HUMAN	Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. Note=Localized at the brush border membranes of the proximal tubules. 
# TCDB	2.A.66.1.20	the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily
# TIGRFAMs	TIGR00797	matE
# TISSUE SPECIFICITY	Isoform 3 is predominantly expressed in kidney. Isoform 6 is expressed in brain. {ECO:0000269|PubMed	16807400}. 
# UCSC	uc002gwe	human. [Q86VL8-1]
# eggNOG	COG0534	LUCA
# eggNOG	KOG1347	Eukaryota
BLAST	swissprot:S47A2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S47A2_HUMAN
COG	COG0534	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0534
COXPRESdb	146802	http://coxpresdb.jp/data/gene/146802.shtml
CleanEx	HS_SLC47A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC47A2
DOI	10.1016/j.bcp.2007.04.010	http://dx.doi.org/10.1016/j.bcp.2007.04.010
DOI	10.1016/j.tips.2006.09.001	http://dx.doi.org/10.1016/j.tips.2006.09.001
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.1681/ASN.2006030205	http://dx.doi.org/10.1681/ASN.2006030205
DrugBank	DB00787	http://www.drugbank.ca/drugs/DB00787
EMBL	AB250364	http://www.ebi.ac.uk/ena/data/view/AB250364
EMBL	AB250701	http://www.ebi.ac.uk/ena/data/view/AB250701
EMBL	AK055758	http://www.ebi.ac.uk/ena/data/view/AK055758
EMBL	BC035288	http://www.ebi.ac.uk/ena/data/view/BC035288
EMBL	BC050578	http://www.ebi.ac.uk/ena/data/view/BC050578
EMBL	BX648861	http://www.ebi.ac.uk/ena/data/view/BX648861
EMBL	CH471212	http://www.ebi.ac.uk/ena/data/view/CH471212
EMBL	CH471212	http://www.ebi.ac.uk/ena/data/view/CH471212
EMBL	CH471212	http://www.ebi.ac.uk/ena/data/view/CH471212
Ensembl	ENST00000325411	http://www.ensembl.org/id/ENST00000325411
Ensembl	ENST00000350657	http://www.ensembl.org/id/ENST00000350657
Ensembl	ENST00000574239	http://www.ensembl.org/id/ENST00000574239
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015238	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015238
GO_function	GO:0015307	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015307
GO_process	GO:0006855	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006855
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC47A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC47A2
GeneID	146802	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=146802
GeneTree	ENSGT00390000015713	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000015713
H-InvDB	HIX0039367	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0039367
HGNC	HGNC:26439	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:26439
HOGENOM	HOG000060313	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000060313&db=HOGENOM6
HOVERGEN	HBG056043	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG056043&db=HOVERGEN
InParanoid	Q86VL8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q86VL8
InterPro	IPR002528	http://www.ebi.ac.uk/interpro/entry/IPR002528
Jabion	146802	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=146802
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:146802	http://www.genome.jp/dbget-bin/www_bget?hsa:146802
KEGG_Orthology	KO:K03327	http://www.genome.jp/dbget-bin/www_bget?KO:K03327
MIM	609833	http://www.ncbi.nlm.nih.gov/omim/609833
MINT	MINT-4723030	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4723030
OMA	IVACYHV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IVACYHV
OrthoDB	EOG091G06X2	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G06X2
PSORT	swissprot:S47A2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S47A2_HUMAN
PSORT-B	swissprot:S47A2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S47A2_HUMAN
PSORT2	swissprot:S47A2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S47A2_HUMAN
Pfam	PF01554	http://pfam.xfam.org/family/PF01554
PharmGKB	PA162403847	http://www.pharmgkb.org/do/serve?objId=PA162403847&objCls=Gene
Phobius	swissprot:S47A2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S47A2_HUMAN
PhylomeDB	Q86VL8	http://phylomedb.org/?seqid=Q86VL8
ProteinModelPortal	Q86VL8	http://www.proteinmodelportal.org/query/uniprot/Q86VL8
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16807400	http://www.ncbi.nlm.nih.gov/pubmed/16807400
PubMed	16996621	http://www.ncbi.nlm.nih.gov/pubmed/16996621
PubMed	17509534	http://www.ncbi.nlm.nih.gov/pubmed/17509534
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
Reactome	R-HSA-425366	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425366
RefSeq	NP_001093116	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001093116
RefSeq	NP_001243592	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243592
RefSeq	NP_690872	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_690872
STRING	9606.ENSP00000326671	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000326671&targetmode=cogs
STRING	COG0534	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0534&targetmode=cogs
TCDB	2.A.66.1.20	http://www.tcdb.org/search/result.php?tc=2.A.66.1.20
TIGRFAMs	TIGR00797	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00797
UCSC	uc002gwe	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002gwe&org=rat
UniGene	Hs.126830	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.126830
UniProtKB	S47A2_HUMAN	http://www.uniprot.org/uniprot/S47A2_HUMAN
UniProtKB-AC	Q86VL8	http://www.uniprot.org/uniprot/Q86VL8
charge	swissprot:S47A2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S47A2_HUMAN
eggNOG	COG0534	http://eggnogapi.embl.de/nog_data/html/tree/COG0534
eggNOG	KOG1347	http://eggnogapi.embl.de/nog_data/html/tree/KOG1347
epestfind	swissprot:S47A2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S47A2_HUMAN
garnier	swissprot:S47A2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S47A2_HUMAN
helixturnhelix	swissprot:S47A2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S47A2_HUMAN
hmoment	swissprot:S47A2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S47A2_HUMAN
iep	swissprot:S47A2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S47A2_HUMAN
inforesidue	swissprot:S47A2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S47A2_HUMAN
neXtProt	NX_Q86VL8	http://www.nextprot.org/db/entry/NX_Q86VL8
octanol	swissprot:S47A2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S47A2_HUMAN
pepcoil	swissprot:S47A2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S47A2_HUMAN
pepdigest	swissprot:S47A2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S47A2_HUMAN
pepinfo	swissprot:S47A2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S47A2_HUMAN
pepnet	swissprot:S47A2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S47A2_HUMAN
pepstats	swissprot:S47A2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S47A2_HUMAN
pepwheel	swissprot:S47A2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S47A2_HUMAN
pepwindow	swissprot:S47A2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S47A2_HUMAN
sigcleave	swissprot:S47A2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S47A2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ITPR1_HUMAN	Event=Alternative splicing; Named isoforms=8; Comment=There is a combination of three alternatively spliced domains at site SI, SIII and site SII (A and C). Experimental confirmation may be lacking for some isoforms.; Name=1; Synonyms=SISIIISIIAC; IsoId=Q14643-1; Sequence=Displayed; Name=2; Synonyms=SI-SIIISIIAC; IsoId=Q14643-2; Sequence=VSP_002687; Name=3; Synonyms=SISIII-SII; IsoId=Q14643-3; Sequence=VSP_002688, VSP_002689, VSP_002690; Name=4; Synonyms=SI-SIII-SII; IsoId=Q14643-4; Sequence=VSP_002687, VSP_002688, VSP_002689, VSP_002690; Name=5; Synonyms=SI-SIII-SIIAC; IsoId=Q14643-5; Sequence=VSP_002687, VSP_002688; Name=6; Synonyms=SISIIISIIA; IsoId=Q14643-6; Sequence=VSP_002690; Name=7; Synonyms=SI-SIII-SIIA; IsoId=Q14643-7; Sequence=VSP_002687, VSP_002690; Name=8; Synonyms=SI-SIII-SIIA; IsoId=Q14643-8; Sequence=VSP_002687, VSP_002688, VSP_002690; 
# AltName	ITPR1_HUMAN	IP3 receptor isoform 1
# AltName	ITPR1_HUMAN	Type 1 inositol 1,4,5-trisphosphate receptor
# BioGrid	109913	48
# CAUTION	Alternative splice sites (AA 1053-1054) represent a non- canonical GA-AG donor-acceptor pair, but are well-supported by all available human transcripts, and by homologous transcripts in mouse, rat and cow. {ECO	0000305}.
# CCDS	CCDS46740	-. [Q14643-3]
# CCDS	CCDS54550	-. [Q14643-4]
# CCDS	CCDS54551	-. [Q14643-2]
# ChiTaRS	ITPR1	human
# DISEASE	ITPR1_HUMAN	Spinocerebellar ataxia 15 (SCA15) [MIM 606658]  Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA15 is an autosomal dominant cerebellar ataxia (ADCA). It is very slow progressing form with a wide range of onset, ranging from childhood to adult. Most patients remain ambulatory. {ECO 0000269|PubMed 17590087, ECO 0000269|PubMed 18579805}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	ITPR1_HUMAN	Spinocerebellar ataxia 29 (SCA29) [MIM 117360]  An autosomal dominant, congenital spinocerebellar ataxia characterized by early motor delay, hypotonia and mild cognitive delay. Affected individuals develop a very slowly progressive or non-progressive gait and limb ataxia associated with cerebellar atrophy on brain imaging. Additional variable features include nystagmus, dysarthria, and tremor. {ECO 0000269|PubMed 22986007, ECO 0000269|PubMed 26770814}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	ITPR1_HUMAN	The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand- binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. 
# DrugBank	DB00201	Caffeine
# Ensembl	ENST00000302640	ENSP00000306253; ENSG00000150995. [Q14643-2]
# Ensembl	ENST00000354582	ENSP00000346595; ENSG00000150995. [Q14643-1]
# Ensembl	ENST00000357086	ENSP00000349597; ENSG00000150995. [Q14643-3]
# Ensembl	ENST00000443694	ENSP00000401671; ENSG00000150995. [Q14643-2]
# Ensembl	ENST00000456211	ENSP00000397885; ENSG00000150995. [Q14643-4]
# ExpressionAtlas	Q14643	baseline and differential
# FUNCTION	ITPR1_HUMAN	Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity). {ECO 0000250|UniProtKB P11881}. 
# GO_component	GO:0005637	nuclear inner membrane; IEA:Ensembl.
# GO_component	GO:0005730	nucleolus; IEA:Ensembl.
# GO_component	GO:0005783	endoplasmic reticulum; NAS:UniProtKB.
# GO_component	GO:0005789	endoplasmic reticulum membrane; IBA:GO_Central.
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0005955	calcineurin complex; IEA:Ensembl.
# GO_component	GO:0014069	postsynaptic density; IEA:Ensembl.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0016529	sarcoplasmic reticulum; IBA:GO_Central.
# GO_component	GO:0031088	platelet dense granule membrane; IDA:BHF-UCL.
# GO_component	GO:0031094	platelet dense tubular network; IDA:BHF-UCL.
# GO_component	GO:0031095	platelet dense tubular network membrane; TAS:Reactome.
# GO_component	GO:0043234	protein complex; IEA:Ensembl.
# GO_function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; ISS:UniProtKB.
# GO_function	GO:0005509	calcium ion binding; IBA:GO_Central.
# GO_function	GO:0015085	calcium ion transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0015278	calcium-release channel activity; ISS:UniProtKB.
# GO_function	GO:0019855	calcium channel inhibitor activity; IDA:GO_Central.
# GO_function	GO:0035091	phosphatidylinositol binding; ISS:UniProtKB.
# GO_function	GO:0070679	inositol 1,4,5 trisphosphate binding; IBA:GO_Central.
# GO_process	GO:0001666	response to hypoxia; IDA:BHF-UCL.
# GO_process	GO:0006816	calcium ion transport; NAS:UniProtKB.
# GO_process	GO:0007165	signal transduction; NAS:UniProtKB.
# GO_process	GO:0009791	post-embryonic development; IEA:Ensembl.
# GO_process	GO:0010506	regulation of autophagy; TAS:ParkinsonsUK-UCL.
# GO_process	GO:0030168	platelet activation; TAS:Reactome.
# GO_process	GO:0032469	endoplasmic reticulum calcium ion homeostasis; IEA:Ensembl.
# GO_process	GO:0042045	epithelial fluid transport; IEA:Ensembl.
# GO_process	GO:0050796	regulation of insulin secretion; TAS:Reactome.
# GO_process	GO:0050849	negative regulation of calcium-mediated signaling; IDA:GO_Central.
# GO_process	GO:0050882	voluntary musculoskeletal movement; IEA:Ensembl.
# GO_process	GO:0051209	release of sequestered calcium ion into cytosol; ISS:UniProtKB.
# GO_process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; ISS:UniProtKB.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005730	nucleolus
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0008289	lipid binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.25.10.30	-; 2.
# Genevisible	Q14643	HS
# HGNC	HGNC:6180	ITPR1
# INTERACTION	ITPR1_HUMAN	P21796 VDAC1; NbExp=3; IntAct=EBI-465548, EBI-354158; 
# IntAct	Q14643	18
# InterPro	IPR000493	InsP3_rcpt-bd
# InterPro	IPR000699	RIH_dom
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR013662	RIH_assoc-dom
# InterPro	IPR014821	Ins145_P3_rcpt
# InterPro	IPR015925	Ryanodine_recept-rel
# InterPro	IPR016024	ARM-type_fold
# InterPro	IPR016093	MIR_motif
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00063	[Neurodegenerative disease] Spinocerebellar ataxia (SCA)
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04070	Phosphatidylinositol signaling system
# KEGG_Pathway	ko04114	Oocyte meiosis
# KEGG_Pathway	ko04270	Vascular smooth muscle contraction
# KEGG_Pathway	ko04540	Gap junction
# KEGG_Pathway	ko04713	Circadian entrainment
# KEGG_Pathway	ko04720	Long-term potentiation
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04724	Glutamatergic synapse
# KEGG_Pathway	ko04725	Cholinergic synapse
# KEGG_Pathway	ko04726	Serotonergic synapse
# KEGG_Pathway	ko04728	Dopaminergic synapse
# KEGG_Pathway	ko04730	Long-term depression
# KEGG_Pathway	ko04745	Phototransduction - fly
# KEGG_Pathway	ko04912	GnRH signaling pathway
# KEGG_Pathway	ko04970	Salivary secretion
# KEGG_Pathway	ko04971	Gastric acid secretion
# KEGG_Pathway	ko04972	Pancreatic secretion
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	117360	phenotype
# MIM	147265	gene
# MIM	606658	phenotype
# MISCELLANEOUS	ITPR1_HUMAN	Calcium appears to inhibit ligand binding to the receptor, most probably by interacting with a distinct calcium- binding protein which then inhibits the receptor. 
# Organism	ITPR1_HUMAN	Homo sapiens (Human)
# Orphanet	208513	Spinocerebellar ataxia type 29
# Orphanet	98769	Spinocerebellar ataxia type 15/16
# PANTHER	PTHR13715	PTHR13715
# PIR	A55713	A55713
# PIR	S54974	S54974
# PRINTS	PR00779	INSP3RECEPTR
# PROSITE	PS50919	MIR; 5
# PTM	ITPR1_HUMAN	Phosphorylated by cAMP kinase (PKA). Phosphorylation prevents the ligand-induced opening of the calcium channels. Phosphorylation by PKA increases the interaction with inositol 1,4,5-trisphosphate and decreases the interaction with AHCYL1. {ECO 0000250|UniProtKB P11881}. 
# PTM	ITPR1_HUMAN	Phosphorylated on tyrosine residues. {ECO 0000269|PubMed 7852357}. 
# PTM	ITPR1_HUMAN	Ubiquitination at multiple lysines targets ITPR1 for proteasomal degradation. Approximately 40% of the ITPR1-associated ubiquitin is monoubiquitin, and polyubiquitins are both 'Lys-48'- and 'Lys-63'-linked (By similarity). {ECO 0000250|UniProtKB P29994}. 
# Pfam	PF00520	Ion_trans
# Pfam	PF01365	RYDR_ITPR; 2
# Pfam	PF02815	MIR
# Pfam	PF08454	RIH_assoc
# Pfam	PF08709	Ins145_P3_rec
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-112043	PLC beta mediated events
# Reactome	R-HSA-114508	Effects of PIP2 hydrolysis
# Reactome	R-HSA-139853	Elevation of cytosolic Ca2+ levels
# Reactome	R-HSA-1489509	DAG and IP3 signaling
# Reactome	R-HSA-2029485	Role of phospholipids in phagocytosis
# Reactome	R-HSA-2871809	FCERI mediated Ca+2 mobilization
# Reactome	R-HSA-381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
# Reactome	R-HSA-4086398	Ca2+ pathway
# Reactome	R-HSA-418457	cGMP effects
# Reactome	R-HSA-422356	Regulation of insulin secretion
# Reactome	R-HSA-5218921	VEGFR2 mediated cell proliferation
# Reactome	R-HSA-5578775	Ion homeostasis
# Reactome	R-HSA-5607763	CLEC7A (Dectin-1) induces NFAT activation
# Reactome	R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
# RecName	ITPR1_HUMAN	Inositol 1,4,5-trisphosphate receptor type 1
# RefSeq	NP_001093422	NM_001099952.2. [Q14643-3]
# RefSeq	NP_002213	NM_002222.5. [Q14643-4]
# RefSeq	XP_011531985	XM_011533683.2. [Q14643-1]
# SIMILARITY	Belongs to the InsP3 receptor family. {ECO	0000305}. 
# SIMILARITY	Contains 5 MIR domains. {ECO:0000255|PROSITE- ProRule	PRU00131}. 
# SMART	SM00472	MIR; 4
# SUBCELLULAR LOCATION	ITPR1_HUMAN	Endoplasmic reticulum membrane; Multi-pass membrane protein. 
# SUBUNIT	ITPR1_HUMAN	Homotetramer. Interacts with TRPC4. The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3. Interacts with ERP44 in a pH-, redox state- and calcium- dependent manner which results in the inhibition the calcium channel activity. The strength of this interaction inversely correlates with calcium concentration. Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1. Interacts with MRVI1 and CABP1 (via N-terminus). Interacts with TESPA1. Interacts (when not phosphorylated) with AHCYL1 (when phosphorylated); the interaction suppresses inositol 1,4,5- trisphosphate binding to ITPR1 (PubMed 16793548). Interacts with AHCYL2 (with lower affinity than with AHCYL1) (PubMed 19220705). Interacts with BOK (via BH4 domain); protects ITPR1 from proteolysis by CASP3 during apoptosis (PubMed 23884412). {ECO 0000269|PubMed 12032348, ECO 0000269|PubMed 14685260, ECO 0000269|PubMed 15652484, ECO 0000269|PubMed 16793548, ECO 0000269|PubMed 16990611, ECO 0000269|PubMed 19220705, ECO 0000269|PubMed 23650607, ECO 0000269|PubMed 23884412}. 
# SUPFAM	SSF100909	SSF100909; 2
# SUPFAM	SSF48371	SSF48371; 4
# SUPFAM	SSF82109	SSF82109; 2
# TCDB	1.A.3.2	the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family
# TISSUE SPECIFICITY	ITPR1_HUMAN	Widely expressed. 
# UCSC	uc003bqc	human. [Q14643-1]
# eggNOG	ENOG410XR97	LUCA
# eggNOG	KOG3533	Eukaryota
BLAST	swissprot:ITPR1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ITPR1_HUMAN
BioCyc	ZFISH:ENSG00000150995-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000150995-MONOMER
COXPRESdb	3708	http://coxpresdb.jp/data/gene/3708.shtml
CleanEx	HS_ITPR1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ITPR1
DIP	DIP-29714N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29714N
DOI	10.1016/0169-328X(95)00089-B	http://dx.doi.org/10.1016/0169-328X(95)00089-B
DOI	10.1016/j.cell.2004.11.048	http://dx.doi.org/10.1016/j.cell.2004.11.048
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.fob.2012.08.005	http://dx.doi.org/10.1016/j.fob.2012.08.005
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.molcel.2006.05.017	http://dx.doi.org/10.1016/j.molcel.2006.05.017
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/nature04728	http://dx.doi.org/10.1038/nature04728
DOI	10.1038/sj.emboj.7600037	http://dx.doi.org/10.1038/sj.emboj.7600037
DOI	10.1042/bj3020781	http://dx.doi.org/10.1042/bj3020781
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.102006299	http://dx.doi.org/10.1073/pnas.102006299
DOI	10.1074/jbc.270.6.2833	http://dx.doi.org/10.1074/jbc.270.6.2833
DOI	10.1074/jbc.M113.496570	http://dx.doi.org/10.1074/jbc.M113.496570
DOI	10.1080/095530096145544	http://dx.doi.org/10.1080/095530096145544
DOI	10.1111/j.1471-4159.2009.05979.x	http://dx.doi.org/10.1111/j.1471-4159.2009.05979.x
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1182/blood-2005-10-026294	http://dx.doi.org/10.1182/blood-2005-10-026294
DOI	10.1186/1750-1172-7-67	http://dx.doi.org/10.1186/1750-1172-7-67
DOI	10.1186/s40673-016-0040-8	http://dx.doi.org/10.1186/s40673-016-0040-8
DOI	10.1212/01.wnl.0000311277.71046.a0	http://dx.doi.org/10.1212/01.wnl.0000311277.71046.a0
DOI	10.1371/journal.pgen.0030108	http://dx.doi.org/10.1371/journal.pgen.0030108
DrugBank	DB00201	http://www.drugbank.ca/drugs/DB00201
EMBL	AC018816	http://www.ebi.ac.uk/ena/data/view/AC018816
EMBL	AC024168	http://www.ebi.ac.uk/ena/data/view/AC024168
EMBL	AC069248	http://www.ebi.ac.uk/ena/data/view/AC069248
EMBL	AC090944	http://www.ebi.ac.uk/ena/data/view/AC090944
EMBL	D26070	http://www.ebi.ac.uk/ena/data/view/D26070
EMBL	L38019	http://www.ebi.ac.uk/ena/data/view/L38019
EMBL	S82269	http://www.ebi.ac.uk/ena/data/view/S82269
EMBL	U23850	http://www.ebi.ac.uk/ena/data/view/U23850
Ensembl	ENST00000302640	http://www.ensembl.org/id/ENST00000302640
Ensembl	ENST00000354582	http://www.ensembl.org/id/ENST00000354582
Ensembl	ENST00000357086	http://www.ensembl.org/id/ENST00000357086
Ensembl	ENST00000443694	http://www.ensembl.org/id/ENST00000443694
Ensembl	ENST00000456211	http://www.ensembl.org/id/ENST00000456211
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005637	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005637
GO_component	GO:0005730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005730
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005955	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005955
GO_component	GO:0014069	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014069
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016529	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016529
GO_component	GO:0031088	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031088
GO_component	GO:0031094	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031094
GO_component	GO:0031095	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031095
GO_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GO_function	GO:0005220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005220
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0015085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015085
GO_function	GO:0015278	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015278
GO_function	GO:0019855	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019855
GO_function	GO:0035091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035091
GO_function	GO:0070679	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070679
GO_process	GO:0001666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001666
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0009791	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009791
GO_process	GO:0010506	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010506
GO_process	GO:0030168	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030168
GO_process	GO:0032469	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032469
GO_process	GO:0042045	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042045
GO_process	GO:0050796	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050796
GO_process	GO:0050849	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050849
GO_process	GO:0050882	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050882
GO_process	GO:0051209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051209
GO_process	GO:0070059	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070059
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005730
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0008289	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.25.10.30	http://www.cathdb.info/version/latest/superfamily/1.25.10.30
GeneCards	ITPR1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ITPR1
GeneID	3708	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3708
GeneTree	ENSGT00760000119152	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119152
HGNC	HGNC:6180	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6180
HOGENOM	HOG000007660	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007660&db=HOGENOM6
HOVERGEN	HBG052158	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052158&db=HOVERGEN
HPA	HPA014765	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014765
HPA	HPA016487	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA016487
InParanoid	Q14643	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q14643
IntAct	Q14643	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q14643*
InterPro	IPR000493	http://www.ebi.ac.uk/interpro/entry/IPR000493
InterPro	IPR000699	http://www.ebi.ac.uk/interpro/entry/IPR000699
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR013662	http://www.ebi.ac.uk/interpro/entry/IPR013662
InterPro	IPR014821	http://www.ebi.ac.uk/interpro/entry/IPR014821
InterPro	IPR015925	http://www.ebi.ac.uk/interpro/entry/IPR015925
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
InterPro	IPR016093	http://www.ebi.ac.uk/interpro/entry/IPR016093
Jabion	3708	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3708
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00063	http://www.genome.jp/dbget-bin/www_bget?H00063
KEGG_Gene	hsa:3708	http://www.genome.jp/dbget-bin/www_bget?hsa:3708
KEGG_Orthology	KO:K04958	http://www.genome.jp/dbget-bin/www_bget?KO:K04958
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04070	http://www.genome.jp/kegg-bin/show_pathway?ko04070
KEGG_Pathway	ko04114	http://www.genome.jp/kegg-bin/show_pathway?ko04114
KEGG_Pathway	ko04270	http://www.genome.jp/kegg-bin/show_pathway?ko04270
KEGG_Pathway	ko04540	http://www.genome.jp/kegg-bin/show_pathway?ko04540
KEGG_Pathway	ko04713	http://www.genome.jp/kegg-bin/show_pathway?ko04713
KEGG_Pathway	ko04720	http://www.genome.jp/kegg-bin/show_pathway?ko04720
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
KEGG_Pathway	ko04725	http://www.genome.jp/kegg-bin/show_pathway?ko04725
KEGG_Pathway	ko04726	http://www.genome.jp/kegg-bin/show_pathway?ko04726
KEGG_Pathway	ko04728	http://www.genome.jp/kegg-bin/show_pathway?ko04728
KEGG_Pathway	ko04730	http://www.genome.jp/kegg-bin/show_pathway?ko04730
KEGG_Pathway	ko04745	http://www.genome.jp/kegg-bin/show_pathway?ko04745
KEGG_Pathway	ko04912	http://www.genome.jp/kegg-bin/show_pathway?ko04912
KEGG_Pathway	ko04970	http://www.genome.jp/kegg-bin/show_pathway?ko04970
KEGG_Pathway	ko04971	http://www.genome.jp/kegg-bin/show_pathway?ko04971
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	117360	http://www.ncbi.nlm.nih.gov/omim/117360
MIM	147265	http://www.ncbi.nlm.nih.gov/omim/147265
MIM	606658	http://www.ncbi.nlm.nih.gov/omim/606658
MINT	MINT-4991320	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4991320
OMA	DPDDHYQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DPDDHYQ
Orphanet	208513	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=208513
Orphanet	98769	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98769
OrthoDB	EOG091G00T2	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00T2
PANTHER	PTHR13715	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13715
PRINTS	PR00779	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00779
PROSITE	PS50919	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50919
PSORT	swissprot:ITPR1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ITPR1_HUMAN
PSORT-B	swissprot:ITPR1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ITPR1_HUMAN
PSORT2	swissprot:ITPR1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ITPR1_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF01365	http://pfam.xfam.org/family/PF01365
Pfam	PF02815	http://pfam.xfam.org/family/PF02815
Pfam	PF08454	http://pfam.xfam.org/family/PF08454
Pfam	PF08709	http://pfam.xfam.org/family/PF08709
PharmGKB	PA29978	http://www.pharmgkb.org/do/serve?objId=PA29978&objCls=Gene
Phobius	swissprot:ITPR1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ITPR1_HUMAN
PhylomeDB	Q14643	http://phylomedb.org/?seqid=Q14643
ProteinModelPortal	Q14643	http://www.proteinmodelportal.org/query/uniprot/Q14643
PubMed	12032348	http://www.ncbi.nlm.nih.gov/pubmed/12032348
PubMed	14685260	http://www.ncbi.nlm.nih.gov/pubmed/14685260
PubMed	15652484	http://www.ncbi.nlm.nih.gov/pubmed/15652484
PubMed	16641997	http://www.ncbi.nlm.nih.gov/pubmed/16641997
PubMed	16793548	http://www.ncbi.nlm.nih.gov/pubmed/16793548
PubMed	16990611	http://www.ncbi.nlm.nih.gov/pubmed/16990611
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	17590087	http://www.ncbi.nlm.nih.gov/pubmed/17590087
PubMed	18579805	http://www.ncbi.nlm.nih.gov/pubmed/18579805
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	19220705	http://www.ncbi.nlm.nih.gov/pubmed/19220705
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	22986007	http://www.ncbi.nlm.nih.gov/pubmed/22986007
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	23650607	http://www.ncbi.nlm.nih.gov/pubmed/23650607
PubMed	23884412	http://www.ncbi.nlm.nih.gov/pubmed/23884412
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	26770814	http://www.ncbi.nlm.nih.gov/pubmed/26770814
PubMed	7500840	http://www.ncbi.nlm.nih.gov/pubmed/7500840
PubMed	7852357	http://www.ncbi.nlm.nih.gov/pubmed/7852357
PubMed	7945203	http://www.ncbi.nlm.nih.gov/pubmed/7945203
PubMed	8648241	http://www.ncbi.nlm.nih.gov/pubmed/8648241
Reactome	R-HSA-112043	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112043
Reactome	R-HSA-114508	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-114508
Reactome	R-HSA-139853	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-139853
Reactome	R-HSA-1489509	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1489509
Reactome	R-HSA-2029485	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2029485
Reactome	R-HSA-2871809	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2871809
Reactome	R-HSA-381676	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-381676
Reactome	R-HSA-4086398	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-4086398
Reactome	R-HSA-418457	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418457
Reactome	R-HSA-422356	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-422356
Reactome	R-HSA-5218921	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5218921
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
Reactome	R-HSA-5607763	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5607763
Reactome	R-HSA-983695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983695
RefSeq	NP_001093422	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001093422
RefSeq	NP_002213	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002213
RefSeq	XP_011531985	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011531985
SMART	SM00472	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00472
STRING	9606.ENSP00000306253	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000306253&targetmode=cogs
SUPFAM	SSF100909	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF100909
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
SUPFAM	SSF82109	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82109
TCDB	1.A.3.2	http://www.tcdb.org/search/result.php?tc=1.A.3.2
UCSC	uc003bqc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003bqc&org=rat
UniGene	Hs.567295	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.567295
UniGene	Hs.715765	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.715765
UniProtKB	ITPR1_HUMAN	http://www.uniprot.org/uniprot/ITPR1_HUMAN
UniProtKB-AC	Q14643	http://www.uniprot.org/uniprot/Q14643
charge	swissprot:ITPR1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ITPR1_HUMAN
eggNOG	ENOG410XR97	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XR97
eggNOG	KOG3533	http://eggnogapi.embl.de/nog_data/html/tree/KOG3533
epestfind	swissprot:ITPR1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ITPR1_HUMAN
garnier	swissprot:ITPR1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ITPR1_HUMAN
helixturnhelix	swissprot:ITPR1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ITPR1_HUMAN
hmoment	swissprot:ITPR1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ITPR1_HUMAN
iep	swissprot:ITPR1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ITPR1_HUMAN
inforesidue	swissprot:ITPR1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ITPR1_HUMAN
neXtProt	NX_Q14643	http://www.nextprot.org/db/entry/NX_Q14643
octanol	swissprot:ITPR1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ITPR1_HUMAN
pepcoil	swissprot:ITPR1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ITPR1_HUMAN
pepdigest	swissprot:ITPR1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ITPR1_HUMAN
pepinfo	swissprot:ITPR1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ITPR1_HUMAN
pepnet	swissprot:ITPR1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ITPR1_HUMAN
pepstats	swissprot:ITPR1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ITPR1_HUMAN
pepwheel	swissprot:ITPR1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ITPR1_HUMAN
pepwindow	swissprot:ITPR1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ITPR1_HUMAN
sigcleave	swissprot:ITPR1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ITPR1_HUMAN
## Database	ID	URL or Descriptions
# AltName	GBRA1_HUMAN	GABA(A) receptor subunit alpha-1
# BioGrid	108828	8
# DISEASE	GBRA1_HUMAN	Epilepsy, childhood absence 4 (ECA4) [MIM 611136]  A subtype of idiopathic generalized epilepsy characterized by an onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. Tonic-clonic seizures often develop in adolescence. Absence seizures may either remit or persist into adulthood. {ECO 0000269|PubMed 16718694}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# DISEASE	GBRA1_HUMAN	Epilepsy, idiopathic generalized 13 (EIG13) [MIM 611136]  A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. Seizure types include juvenile myoclonic seizures, absence seizures, and generalized tonic-clonic seizures. {ECO 0000269|PubMed 21714819}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# DISEASE	GBRA1_HUMAN	Epileptic encephalopathy, early infantile, 19 (EIEE19) [MIM 615744]  A severe neurologic disorder characterized by onset of seizures in the first months of life and usually associated with EEG abnormalities. Affected infants have convulsive seizures (hemiclonic or generalized) that are often prolonged and triggered by fever. Other seizure types include focal, myoclonic, absence seizures, and drop attacks. Development is normal in the first year of life with later slowing and intellectual disability. {ECO 0000269|PubMed 24623842}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	GBRA1_HUMAN	Juvenile myoclonic epilepsy 5 (EJM5) [MIM 611136]  A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue. {ECO 0000269|PubMed 11992121}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# DrugBank	DB00186	Lorazepam
# DrugBank	DB00189	Ethchlorvynol
# DrugBank	DB00228	Enflurane
# DrugBank	DB00231	Temazepam
# DrugBank	DB00237	Butabarbital
# DrugBank	DB00241	Butalbital
# DrugBank	DB00273	Topiramate
# DrugBank	DB00292	Etomidate
# DrugBank	DB00306	Talbutal
# DrugBank	DB00312	Pentobarbital
# DrugBank	DB00334	Olanzapine
# DrugBank	DB00349	Clobazam
# DrugBank	DB00371	Meprobamate
# DrugBank	DB00402	Eszopiclone
# DrugBank	DB00404	Alprazolam
# DrugBank	DB00418	Secobarbital
# DrugBank	DB00425	Zolpidem
# DrugBank	DB00474	Methohexital
# DrugBank	DB00475	Chlordiazepoxide
# DrugBank	DB00543	Amoxapine
# DrugBank	DB00546	Adinazolam
# DrugBank	DB00599	Thiopental
# DrugBank	DB00628	Clorazepate
# DrugBank	DB00659	Acamprosate
# DrugBank	DB00683	Midazolam
# DrugBank	DB00690	Flurazepam
# DrugBank	DB00753	Isoflurane
# DrugBank	DB00794	Primidone
# DrugBank	DB00801	Halazepam
# DrugBank	DB00818	Propofol
# DrugBank	DB00829	Diazepam
# DrugBank	DB00837	Progabide
# DrugBank	DB00842	Oxazepam
# DrugBank	DB00849	Methylphenobarbital
# DrugBank	DB00897	Triazolam
# DrugBank	DB00898	Ethanol
# DrugBank	DB00962	Zaleplon
# DrugBank	DB01028	Methoxyflurane
# DrugBank	DB01049	Ergoloid mesylate
# DrugBank	DB01068	Clonazepam
# DrugBank	DB01107	Methyprylon
# DrugBank	DB01154	Thiamylal
# DrugBank	DB01159	Halothane
# DrugBank	DB01174	Phenobarbital
# DrugBank	DB01189	Desflurane
# DrugBank	DB01198	Zopiclone
# DrugBank	DB01205	Flumazenil
# DrugBank	DB01215	Estazolam
# DrugBank	DB01236	Sevoflurane
# DrugBank	DB01346	Quinidine barbiturate
# DrugBank	DB01351	Amobarbital
# DrugBank	DB01352	Aprobarbital
# DrugBank	DB01353	Butethal
# DrugBank	DB01354	Heptabarbital
# DrugBank	DB01355	Hexobarbital
# DrugBank	DB01381	Ginkgo biloba
# DrugBank	DB01437	Glutethimide
# DrugBank	DB01558	Bromazepam
# DrugBank	DB01559	Clotiazepam
# DrugBank	DB01567	Fludiazepam
# DrugBank	DB01587	Ketazolam
# DrugBank	DB01588	Prazepam
# DrugBank	DB01589	Quazepam
# DrugBank	DB01594	Cinolazepam
# DrugBank	DB01595	Nitrazepam
# Ensembl	ENST00000023897	ENSP00000023897; ENSG00000022355
# Ensembl	ENST00000393943	ENSP00000377517; ENSG00000022355
# Ensembl	ENST00000428797	ENSP00000393097; ENSG00000022355
# Ensembl	ENST00000437025	ENSP00000415441; ENSG00000022355
# Ensembl	ENST00000635880	ENSP00000489738; ENSG00000022355
# Ensembl	ENST00000636573	ENSP00000490320; ENSG00000022355
# Ensembl	ENST00000637827	ENSP00000490804; ENSG00000022355
# Ensembl	ENST00000638112	ENSP00000489839; ENSG00000022355
# ExpressionAtlas	P14867	baseline and differential
# FUNCTION	GBRA1_HUMAN	Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel (By similarity). {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; ISS:BHF-UCL.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:1902710	GABA receptor complex; ISS:BHF-UCL.
# GO_component	GO:1902711	GABA-A receptor complex; IDA:GO_Central.
# GO_function	GO:0004890	GABA-A receptor activity; TAS:ProtInc.
# GO_function	GO:0008144	drug binding; ISS:BHF-UCL.
# GO_function	GO:0022851	GABA-gated chloride ion channel activity; IDA:GO_Central.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007214	gamma-aminobutyric acid signaling pathway; TAS:ProtInc.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0051932	synaptic transmission, GABAergic; ISS:BHF-UCL.
# GO_process	GO:0071420	cellular response to histamine; IEA:Ensembl.
# GO_process	GO:1902476	chloride transmembrane transport; IDA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.70.170.10	-; 1.
# Genevisible	P14867	HS
# HGNC	HGNC:4075	GABRA1
# InterPro	IPR001390	GABAAa_rcpt
# InterPro	IPR005431	GABBAa1_rcpt
# InterPro	IPR006028	GABAA/Glycine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00808	[Nervous system disease] Familial infantile myoclonic epilepsy (FIME)
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04727	GABAergic synapse
# KEGG_Pathway	ko05032	Morphine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# MIM	137160	gene
# MIM	611136	phenotype
# MIM	615744	phenotype
# Organism	GBRA1_HUMAN	Homo sapiens (Human)
# Orphanet	307	Juvenile myoclonic epilepsy
# Orphanet	33069	Dravet syndrome
# Orphanet	64280	Childhood absence epilepsy
# PANTHER	PTHR18945	PTHR18945
# PIR	A31588	A31588
# PIR	A60652	A60652
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00253	GABAARECEPTR
# PRINTS	PR01079	GABAARALPHA
# PRINTS	PR01614	GABAARALPHA1
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-112314	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
# Reactome	R-HSA-975298	Ligand-gated ion channel transport
# Reactome	R-HSA-977441	GABA A receptor activation
# RecName	GBRA1_HUMAN	Gamma-aminobutyric acid receptor subunit alpha-1
# RefSeq	NP_000797	NM_000806.5
# RefSeq	NP_001121115	NM_001127643.1
# RefSeq	NP_001121116	NM_001127644.1
# RefSeq	NP_001121117	NM_001127645.1
# RefSeq	NP_001121120	NM_001127648.1
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	GBRA1_HUMAN	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein {ECO 0000255}. Cell membrane {ECO 0000269|PubMed 2465923}; Multi-pass membrane protein {ECO 0000255}. Cytoplasmic vesicle membrane {ECO 0000250|UniProtKB P62813}. 
# SUBUNIT	GBRA1_HUMAN	Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains. Interacts with UBQLN1. Interacts with TRAK1. Interacts with KIF21B. {ECO 0000250|UniProtKB P62812, ECO 0000250|UniProtKB P62813}. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TCDB	1.A.9.5	the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family
# TIGRFAMs	TIGR00860	LIC
# UCSC	uc003lyx	human
# WEB RESOURCE	GBRA1_HUMAN	Name=Protein Spotlight; Note=Forbidden fruit - Issue 56 of March 2005; URL="http //web.expasy.org/spotlight/back_issues/056";
# eggNOG	ENOG410XNQG	LUCA
# eggNOG	KOG3642	Eukaryota
BLAST	swissprot:GBRA1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GBRA1_HUMAN
BioCyc	ZFISH:ENSG00000022355-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000022355-MONOMER
COXPRESdb	2554	http://coxpresdb.jp/data/gene/2554.shtml
CleanEx	HS_GABRA1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GABRA1
DOI	10.1002/ana.20874	http://dx.doi.org/10.1002/ana.20874
DOI	10.1016/0014-5793(89)80563-0	http://dx.doi.org/10.1016/0014-5793(89)80563-0
DOI	10.1016/S0006-291X(88)80949-5	http://dx.doi.org/10.1016/S0006-291X(88)80949-5
DOI	10.1038/ng885	http://dx.doi.org/10.1038/ng885
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1460-9568.2011.07767.x	http://dx.doi.org/10.1111/j.1460-9568.2011.07767.x
DOI	10.1212/WNL.0000000000000291	http://dx.doi.org/10.1212/WNL.0000000000000291
DrugBank	DB00186	http://www.drugbank.ca/drugs/DB00186
DrugBank	DB00189	http://www.drugbank.ca/drugs/DB00189
DrugBank	DB00228	http://www.drugbank.ca/drugs/DB00228
DrugBank	DB00231	http://www.drugbank.ca/drugs/DB00231
DrugBank	DB00237	http://www.drugbank.ca/drugs/DB00237
DrugBank	DB00241	http://www.drugbank.ca/drugs/DB00241
DrugBank	DB00273	http://www.drugbank.ca/drugs/DB00273
DrugBank	DB00292	http://www.drugbank.ca/drugs/DB00292
DrugBank	DB00306	http://www.drugbank.ca/drugs/DB00306
DrugBank	DB00312	http://www.drugbank.ca/drugs/DB00312
DrugBank	DB00334	http://www.drugbank.ca/drugs/DB00334
DrugBank	DB00349	http://www.drugbank.ca/drugs/DB00349
DrugBank	DB00371	http://www.drugbank.ca/drugs/DB00371
DrugBank	DB00402	http://www.drugbank.ca/drugs/DB00402
DrugBank	DB00404	http://www.drugbank.ca/drugs/DB00404
DrugBank	DB00418	http://www.drugbank.ca/drugs/DB00418
DrugBank	DB00425	http://www.drugbank.ca/drugs/DB00425
DrugBank	DB00474	http://www.drugbank.ca/drugs/DB00474
DrugBank	DB00475	http://www.drugbank.ca/drugs/DB00475
DrugBank	DB00543	http://www.drugbank.ca/drugs/DB00543
DrugBank	DB00546	http://www.drugbank.ca/drugs/DB00546
DrugBank	DB00599	http://www.drugbank.ca/drugs/DB00599
DrugBank	DB00628	http://www.drugbank.ca/drugs/DB00628
DrugBank	DB00659	http://www.drugbank.ca/drugs/DB00659
DrugBank	DB00683	http://www.drugbank.ca/drugs/DB00683
DrugBank	DB00690	http://www.drugbank.ca/drugs/DB00690
DrugBank	DB00753	http://www.drugbank.ca/drugs/DB00753
DrugBank	DB00794	http://www.drugbank.ca/drugs/DB00794
DrugBank	DB00801	http://www.drugbank.ca/drugs/DB00801
DrugBank	DB00818	http://www.drugbank.ca/drugs/DB00818
DrugBank	DB00829	http://www.drugbank.ca/drugs/DB00829
DrugBank	DB00837	http://www.drugbank.ca/drugs/DB00837
DrugBank	DB00842	http://www.drugbank.ca/drugs/DB00842
DrugBank	DB00849	http://www.drugbank.ca/drugs/DB00849
DrugBank	DB00897	http://www.drugbank.ca/drugs/DB00897
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB00962	http://www.drugbank.ca/drugs/DB00962
DrugBank	DB01028	http://www.drugbank.ca/drugs/DB01028
DrugBank	DB01049	http://www.drugbank.ca/drugs/DB01049
DrugBank	DB01068	http://www.drugbank.ca/drugs/DB01068
DrugBank	DB01107	http://www.drugbank.ca/drugs/DB01107
DrugBank	DB01154	http://www.drugbank.ca/drugs/DB01154
DrugBank	DB01159	http://www.drugbank.ca/drugs/DB01159
DrugBank	DB01174	http://www.drugbank.ca/drugs/DB01174
DrugBank	DB01189	http://www.drugbank.ca/drugs/DB01189
DrugBank	DB01198	http://www.drugbank.ca/drugs/DB01198
DrugBank	DB01205	http://www.drugbank.ca/drugs/DB01205
DrugBank	DB01215	http://www.drugbank.ca/drugs/DB01215
DrugBank	DB01236	http://www.drugbank.ca/drugs/DB01236
DrugBank	DB01346	http://www.drugbank.ca/drugs/DB01346
DrugBank	DB01351	http://www.drugbank.ca/drugs/DB01351
DrugBank	DB01352	http://www.drugbank.ca/drugs/DB01352
DrugBank	DB01353	http://www.drugbank.ca/drugs/DB01353
DrugBank	DB01354	http://www.drugbank.ca/drugs/DB01354
DrugBank	DB01355	http://www.drugbank.ca/drugs/DB01355
DrugBank	DB01381	http://www.drugbank.ca/drugs/DB01381
DrugBank	DB01437	http://www.drugbank.ca/drugs/DB01437
DrugBank	DB01558	http://www.drugbank.ca/drugs/DB01558
DrugBank	DB01559	http://www.drugbank.ca/drugs/DB01559
DrugBank	DB01567	http://www.drugbank.ca/drugs/DB01567
DrugBank	DB01587	http://www.drugbank.ca/drugs/DB01587
DrugBank	DB01588	http://www.drugbank.ca/drugs/DB01588
DrugBank	DB01589	http://www.drugbank.ca/drugs/DB01589
DrugBank	DB01594	http://www.drugbank.ca/drugs/DB01594
DrugBank	DB01595	http://www.drugbank.ca/drugs/DB01595
EMBL	BC030696	http://www.ebi.ac.uk/ena/data/view/BC030696
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	X13584	http://www.ebi.ac.uk/ena/data/view/X13584
EMBL	X14766	http://www.ebi.ac.uk/ena/data/view/X14766
Ensembl	ENST00000023897	http://www.ensembl.org/id/ENST00000023897
Ensembl	ENST00000393943	http://www.ensembl.org/id/ENST00000393943
Ensembl	ENST00000428797	http://www.ensembl.org/id/ENST00000428797
Ensembl	ENST00000437025	http://www.ensembl.org/id/ENST00000437025
Ensembl	ENST00000635880	http://www.ensembl.org/id/ENST00000635880
Ensembl	ENST00000636573	http://www.ensembl.org/id/ENST00000636573
Ensembl	ENST00000637827	http://www.ensembl.org/id/ENST00000637827
Ensembl	ENST00000638112	http://www.ensembl.org/id/ENST00000638112
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_component	GO:1902710	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902710
GO_component	GO:1902711	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902711
GO_function	GO:0004890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004890
GO_function	GO:0008144	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008144
GO_function	GO:0022851	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022851
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007214	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007214
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0051932	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051932
GO_process	GO:0071420	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071420
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	GABRA1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GABRA1
GeneID	2554	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2554
GeneTree	ENSGT00760000119010	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119010
HGNC	HGNC:4075	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4075
HOGENOM	HOG000231337	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231337&db=HOGENOM6
HOVERGEN	HBG051707	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051707&db=HOVERGEN
HPA	CAB022502	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB022502
HPA	HPA055746	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA055746
InParanoid	P14867	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P14867
IntAct	P14867	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P14867*
InterPro	IPR001390	http://www.ebi.ac.uk/interpro/entry/IPR001390
InterPro	IPR005431	http://www.ebi.ac.uk/interpro/entry/IPR005431
InterPro	IPR006028	http://www.ebi.ac.uk/interpro/entry/IPR006028
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
Jabion	2554	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2554
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00808	http://www.genome.jp/dbget-bin/www_bget?H00808
KEGG_Gene	hsa:2554	http://www.genome.jp/dbget-bin/www_bget?hsa:2554
KEGG_Orthology	KO:K05175	http://www.genome.jp/dbget-bin/www_bget?KO:K05175
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
KEGG_Pathway	ko05032	http://www.genome.jp/kegg-bin/show_pathway?ko05032
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
MIM	137160	http://www.ncbi.nlm.nih.gov/omim/137160
MIM	611136	http://www.ncbi.nlm.nih.gov/omim/611136
MIM	615744	http://www.ncbi.nlm.nih.gov/omim/615744
OMA	INTIHFL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=INTIHFL
Orphanet	307	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=307
Orphanet	33069	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=33069
Orphanet	64280	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=64280
OrthoDB	EOG091G0805	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0805
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00253	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00253
PRINTS	PR01079	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01079
PRINTS	PR01614	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01614
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:GBRA1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GBRA1_HUMAN
PSORT-B	swissprot:GBRA1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GBRA1_HUMAN
PSORT2	swissprot:GBRA1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GBRA1_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA28489	http://www.pharmgkb.org/do/serve?objId=PA28489&objCls=Gene
Phobius	swissprot:GBRA1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GBRA1_HUMAN
PhylomeDB	P14867	http://phylomedb.org/?seqid=P14867
ProteinModelPortal	P14867	http://www.proteinmodelportal.org/query/uniprot/P14867
PubMed	11992121	http://www.ncbi.nlm.nih.gov/pubmed/11992121
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16718694	http://www.ncbi.nlm.nih.gov/pubmed/16718694
PubMed	21714819	http://www.ncbi.nlm.nih.gov/pubmed/21714819
PubMed	24623842	http://www.ncbi.nlm.nih.gov/pubmed/24623842
PubMed	2465923	http://www.ncbi.nlm.nih.gov/pubmed/2465923
PubMed	2847710	http://www.ncbi.nlm.nih.gov/pubmed/2847710
Reactome	R-HSA-112314	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112314
Reactome	R-HSA-975298	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-975298
Reactome	R-HSA-977441	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-977441
RefSeq	NP_000797	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000797
RefSeq	NP_001121115	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001121115
RefSeq	NP_001121116	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001121116
RefSeq	NP_001121117	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001121117
RefSeq	NP_001121120	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001121120
SMR	P14867	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P14867
STRING	9606.ENSP00000023897	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000023897&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TCDB	1.A.9.5	http://www.tcdb.org/search/result.php?tc=1.A.9.5
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc003lyx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003lyx&org=rat
UniGene	Hs.175934	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.175934
UniProtKB	GBRA1_HUMAN	http://www.uniprot.org/uniprot/GBRA1_HUMAN
UniProtKB-AC	P14867	http://www.uniprot.org/uniprot/P14867
charge	swissprot:GBRA1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GBRA1_HUMAN
eggNOG	ENOG410XNQG	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNQG
eggNOG	KOG3642	http://eggnogapi.embl.de/nog_data/html/tree/KOG3642
epestfind	swissprot:GBRA1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GBRA1_HUMAN
garnier	swissprot:GBRA1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GBRA1_HUMAN
helixturnhelix	swissprot:GBRA1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GBRA1_HUMAN
hmoment	swissprot:GBRA1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GBRA1_HUMAN
iep	swissprot:GBRA1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GBRA1_HUMAN
inforesidue	swissprot:GBRA1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GBRA1_HUMAN
neXtProt	NX_P14867	http://www.nextprot.org/db/entry/NX_P14867
octanol	swissprot:GBRA1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GBRA1_HUMAN
pepcoil	swissprot:GBRA1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GBRA1_HUMAN
pepdigest	swissprot:GBRA1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GBRA1_HUMAN
pepinfo	swissprot:GBRA1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GBRA1_HUMAN
pepnet	swissprot:GBRA1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GBRA1_HUMAN
pepstats	swissprot:GBRA1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GBRA1_HUMAN
pepwheel	swissprot:GBRA1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GBRA1_HUMAN
pepwindow	swissprot:GBRA1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GBRA1_HUMAN
sigcleave	swissprot:GBRA1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GBRA1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CFTR_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P13569-1; Sequence=Displayed; Name=2; IsoId=P13569-2; Sequence=VSP_022123; Note=Exon skipping favored by a high number of TG repeats and a low number of T repeats at the intron-exon boundary. Causes congenital bilateral absence of the vas deferens (CBAVD).; Name=3; IsoId=P13569-3; Sequence=VSP_022124, VSP_022125; Note=Alternative acceptor site favored by mutation in an exonic splicing enhancer (ESE). Causes cystic fibrosis (CF).; 
# AltName	CFTR_HUMAN	ATP-binding cassette sub-family C member 7
# AltName	CFTR_HUMAN	Channel conductance-controlling ATPase
# AltName	CFTR_HUMAN	cAMP-dependent chloride channel
# BRENDA	3.6.3.49	2681
# BioGrid	107506	274
# CATALYTIC ACTIVITY	CFTR_HUMAN	ATP + H(2)O = ADP + phosphate. 
# CCDS	CCDS5773	-. [P13569-1]
# DISEASE	CFTR_HUMAN	Congenital bilateral absence of the vas deferens (CBAVD) [MIM 277180]  Important cause of sterility in men and could represent an incomplete form of cystic fibrosis, as the majority of men suffering from cystic fibrosis lack the vas deferens. {ECO 0000269|PubMed 10651488, ECO 0000269|PubMed 7529962, ECO 0000269|PubMed 7539342, ECO 0000269|PubMed 9067761, ECO 0000269|Ref.77}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CFTR_HUMAN	Cystic fibrosis (CF) [MIM 219700]  A common generalized disorder of the exocrine glands which impairs clearance of secretions in a variety of organs. It is characterized by the triad of chronic bronchopulmonary disease (with recurrent respiratory infections), pancreatic insufficiency (which leads to malabsorption and growth retardation) and elevated sweat electrolytes. It is the most common genetic disease in Caucasians, with a prevalence of about 1 in 2'000 live births. Inheritance is autosomal recessive. {ECO 0000269|PubMed 10094564, ECO 0000269|PubMed 1284466, ECO 0000269|PubMed 1284468, ECO 0000269|PubMed 1284529, ECO 0000269|PubMed 1284530, ECO 0000269|PubMed 1695717, ECO 0000269|PubMed 1710600, ECO 0000269|PubMed 2236053, ECO 0000269|PubMed 7504969, ECO 0000269|PubMed 7505694, ECO 0000269|PubMed 7513296, ECO 0000269|PubMed 7517264, ECO 0000269|PubMed 7520022, ECO 0000269|PubMed 7522211, ECO 0000269|PubMed 7524909, ECO 0000269|PubMed 7524913, ECO 0000269|PubMed 7525450, ECO 0000269|PubMed 7537150, ECO 0000269|PubMed 7541273, ECO 0000269|PubMed 7541510, ECO 0000269|PubMed 7543567, ECO 0000269|PubMed 7544319, ECO 0000269|PubMed 7581407, ECO 0000269|PubMed 7680525, ECO 0000269|PubMed 7683628, ECO 0000269|PubMed 7683954, ECO 0000269|PubMed 8081395, ECO 0000269|PubMed 8522333, ECO 0000269|PubMed 8723693, ECO 0000269|PubMed 8723695, ECO 0000269|PubMed 8800923, ECO 0000269|PubMed 8829633, ECO 0000269|PubMed 8956039, ECO 0000269|PubMed 9101301, ECO 0000269|PubMed 9222768, ECO 0000269|PubMed 9375855, ECO 0000269|PubMed 9401006, ECO 0000269|PubMed 9443874, ECO 0000269|PubMed 9452048, ECO 0000269|PubMed 9452054, ECO 0000269|PubMed 9452073, ECO 0000269|PubMed 9482579, ECO 0000269|PubMed 9521595, ECO 0000269|PubMed 9554753, ECO 0000269|PubMed 9736778, ECO 0000269|PubMed 9921909}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	CFTR_HUMAN	The PDZ-binding motif mediates interactions with GOPC and with the SLC4A7, SLC9A3R1/EBP50 complex. 
# DrugBank	DB00887	Bumetanide
# DrugBank	DB01016	Glyburide
# DrugBank	DB01050	Ibuprofen
# DrugBank	DB04941	Crofelemer
# DrugBank	DB08820	Ivacaftor
# Ensembl	ENST00000003084	ENSP00000003084; ENSG00000001626. [P13569-1]
# ExpressionAtlas	P13569	baseline and differential
# FUNCTION	CFTR_HUMAN	Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation. {ECO 0000269|PubMed 22178883}. 
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005765	lysosomal membrane; TAS:Reactome.
# GO_component	GO:0005769	early endosome; IDA:UniProtKB.
# GO_component	GO:0005829	cytosol; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0009986	cell surface; IDA:UniProtKB.
# GO_component	GO:0016323	basolateral plasma membrane; NAS:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_component	GO:0030660	Golgi-associated vesicle membrane; TAS:Reactome.
# GO_component	GO:0031901	early endosome membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0043234	protein complex; IDA:UniProtKB.
# GO_component	GO:0055037	recycling endosome; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005224	ATP-binding and phosphorylation-dependent chloride channel activity; TAS:ProtInc.
# GO_function	GO:0005254	chloride channel activity; IDA:UniProtKB.
# GO_function	GO:0005260	channel-conductance-controlling ATPase activity; NAS:UniProtKB.
# GO_function	GO:0005524	ATP binding; TAS:ProtInc.
# GO_function	GO:0015106	bicarbonate transmembrane transporter activity; ISS:UniProtKB.
# GO_function	GO:0015108	chloride transmembrane transporter activity; ISS:UniProtKB.
# GO_function	GO:0017081	chloride channel regulator activity; TAS:Reactome.
# GO_function	GO:0019869	chloride channel inhibitor activity; IDA:UniProtKB.
# GO_function	GO:0019899	enzyme binding; IPI:UniProtKB.
# GO_function	GO:0030165	PDZ domain binding; IDA:UniProtKB.
# GO_function	GO:0043225	ATPase-coupled anion transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0006695	cholesterol biosynthetic process; IEA:Ensembl.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006904	vesicle docking involved in exocytosis; IEA:Ensembl.
# GO_process	GO:0007585	respiratory gaseous exchange; TAS:ProtInc.
# GO_process	GO:0030301	cholesterol transport; IEA:Ensembl.
# GO_process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus; IMP:UniProtKB.
# GO_process	GO:0045921	positive regulation of exocytosis; IMP:UniProtKB.
# GO_process	GO:0048240	sperm capacitation; ISS:UniProtKB.
# GO_process	GO:0051454	intracellular pH elevation; ISS:UniProtKB.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GO_process	GO:0060081	membrane hyperpolarization; ISS:UniProtKB.
# GO_process	GO:0071320	cellular response to cAMP; ISS:UniProtKB.
# GO_process	GO:1902161	positive regulation of cyclic nucleotide-gated ion channel activity; IMP:UniProtKB.
# GO_process	GO:1902476	chloride transmembrane transport; IMP:UniProtKB.
# GO_process	GO:1902943	positive regulation of voltage-gated chloride channel activity; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0021700	developmental maturation
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 2.
# Genevisible	P13569	HS
# HGNC	HGNC:1884	CFTR
# INTERACTION	CFTR_HUMAN	P51572 BCAP31; NbExp=3; IntAct=EBI-349854, EBI-77683; P27824 CANX; NbExp=3; IntAct=EBI-349854, EBI-355947; Q9BUN8 DERL1; NbExp=2; IntAct=EBI-349854, EBI-398977; Q9H8Y8 GORASP2; NbExp=3; IntAct=EBI-349854, EBI-739467; P19120 HSPA8 (xeno); NbExp=2; IntAct=EBI-349854, EBI-907802; P05787 KRT8; NbExp=7; IntAct=EBI-349854, EBI-297852; Q9HBW0 LPAR2; NbExp=4; IntAct=EBI-349854, EBI-765995; Q5T2W1 PDZK1; NbExp=2; IntAct=EBI-349854, EBI-349819; Q99942 RNF5; NbExp=3; IntAct=EBI-349854, EBI-348482; Q9QX74 Shank2 (xeno); NbExp=2; IntAct=EBI-349854, EBI-397902; Q96RN1 SLC26A8; NbExp=2; IntAct=EBI-349854, EBI-1792052; O14745 SLC9A3R1; NbExp=5; IntAct=EBI-349854, EBI-349787; Q15599 SLC9A3R2; NbExp=7; IntAct=EBI-349854, EBI-1149760; 
# IntAct	P13569	138
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR009147	CFTR/ABCC7
# InterPro	IPR011527	ABC1_TM_dom
# InterPro	IPR017871	ABC_transporter_CS
# InterPro	IPR025837	CFTR_reg_dom
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Brite	ko02000	 Transporters
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00218	[Inherited metabolic disease; Digestive disease; Respiratory disease] Cystic fibrosis (CF)
# KEGG_Disease	H00933	[Pancreas disease] Hereditary chronic pancreatitis
# KEGG_Disease	H01033	[Reproductive system disease] Congenital bilateral absence of vas deferens
# KEGG_Pathway	ko02010	ABC transporters
# KEGG_Pathway	ko04971	Gastric acid secretion
# KEGG_Pathway	ko04972	Pancreatic secretion
# KEGG_Pathway	ko04976	Bile secretion
# KEGG_Pathway	ko05110	Vibrio cholerae infection
# MIM	219700	phenotype
# MIM	277180	phenotype
# MIM	602421	gene
# Organism	CFTR_HUMAN	Homo sapiens (Human)
# Orphanet	399805	Male infertility with azoospermia or oligozoospermia due to single gene mutation
# Orphanet	48	Congenital bilateral absence of vas deferens
# Orphanet	586	Cystic fibrosis
# Orphanet	60033	Idiopathic bronchiectasis
# Orphanet	676	Hereditary chronic pancreatitis
# PANTHER	PTHR24223:SF19	PTHR24223:SF19; 3
# PDB	1NBD	Model; -; A=425-638
# PDB	1XMI	X-ray; 2.25 A; A/B/C/D/E=389-678
# PDB	1XMJ	X-ray; 2.30 A; A=389-677
# PDB	2BBO	X-ray; 2.55 A; A=389-678
# PDB	2BBS	X-ray; 2.05 A; A/B=389-677
# PDB	2BBT	X-ray; 2.30 A; A/B=389-678
# PDB	2LOB	NMR; -; B=1473-1480
# PDB	2PZE	X-ray; 1.70 A; A/B=387-646
# PDB	2PZF	X-ray; 2.00 A; A/B=387-646
# PDB	2PZG	X-ray; 1.80 A; A/B=375-646
# PDB	3GD7	X-ray; 2.70 A; A/B/C/D=1193-1427
# PDB	3ISW	X-ray; 2.80 A; C=5-20
# PDB	4WZ6	X-ray; 2.05 A; A=389-678
# PDB	5D2D	X-ray; 2.10 A; C=747-774
# PDB	5D3E	X-ray; 2.75 A; C/G/K=762-801
# PIR	A39069	DVHUCF
# PRINTS	PR01851	CYSFIBREGLTR
# PROSITE	PS00211	ABC_TRANSPORTER_1
# PROSITE	PS50893	ABC_TRANSPORTER_2; 2
# PROSITE	PS50929	ABC_TM1F; 2
# PTM	CFTR_HUMAN	Phosphorylated; activates the channel. It is not clear whether PKC phosphorylation itself activates the channel or permits activation by phosphorylation at PKA sites. Phosphorylated by AMPK. {ECO 0000269|PubMed 12519745, ECO 0000269|PubMed 12588899, ECO 0000269|PubMed 1377674, ECO 0000269|PubMed 22119790, ECO 0000269|PubMed 9385646}. 
# PTM	CFTR_HUMAN	Ubiquitinated, leading to its degradation in the lysosome. Deubiquitination by USP10 in early endosomes, enhances its endocytic recycling. Ubiquitinated by RNF185 during ER stress. {ECO 0000269|PubMed 19398555, ECO 0000269|PubMed 22119790, ECO 0000269|PubMed 24019521}. 
# Pfam	PF00005	ABC_tran; 2
# Pfam	PF00664	ABC_membrane; 2
# Pfam	PF14396	CFTR_R
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-382556	ABC-family proteins mediated transport
# Reactome	R-HSA-5627083	RHO GTPases regulate CFTR trafficking
# Reactome	R-HSA-5678895	Defective CFTR causes cystic fibrosis
# Reactome	R-HSA-5689880	Ub-specific processing proteases
# Reactome	R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis
# Reactome	R-HSA-8856828	Clathrin-mediated endocytosis
# RecName	CFTR_HUMAN	Cystic fibrosis transmembrane conductance regulator
# RefSeq	NP_000483	NM_000492.3. [P13569-1]
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 2 ABC transmembrane type-1 domains. {ECO:0000255|PROSITE-ProRule	PRU00441}. 
# SIMILARITY	Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA; 2
# SUBCELLULAR LOCATION	CFTR_HUMAN	Early endosome membrane {ECO 0000269|PubMed 19398555}; Multi-pass membrane protein {ECO 0000255}. Cell membrane {ECO 0000269|PubMed 22178883}; Multi- pass membrane protein {ECO 0000255}. Note=In the oviduct and bronchus, detected on the apical side of epithelial cells, but not associated with cilia. {ECO 0000269|PubMed 22207244}. 
# SUBUNIT	CFTR_HUMAN	Interacts with SLC26A3, SLC26A6 and SHANK2 (By similarity). Interacts with SLC9A3R1, MYO6 and GOPC. Interacts with SLC4A7 through SLC9A3R1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8. Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). {ECO 0000250|UniProtKB P26361, ECO 0000269|PubMed 11304524, ECO 0000269|PubMed 11707463, ECO 0000269|PubMed 12403779, ECO 0000269|PubMed 15247260, ECO 0000269|PubMed 17462998, ECO 0000269|PubMed 22121115, ECO 0000269|PubMed 22178883}. 
# SUPFAM	SSF52540	SSF52540; 2
# SUPFAM	SSF90123	SSF90123; 2
# TCDB	3.A.1.202	the atp-binding cassette (abc) superfamily
# TIGRFAMs	TIGR01271	CFTR_protein
# TISSUE SPECIFICITY	Expressed in the respiratory airway, including bronchial epithelium, and in the female reproductive tract, including oviduct (at protein level). {ECO:0000269|PubMed	22207244}. 
# UCSC	uc003vjd	human. [P13569-1]
# WEB RESOURCE	CFTR_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=P13569";
# WEB RESOURCE	CFTR_HUMAN	Name=CFTR; Note=Cystic fibrosis mutation db; URL="http //www.genet.sickkids.on.ca/cftr/app"; 
# WEB RESOURCE	CFTR_HUMAN	Name=Wikipedia; Note=CFTR entry; URL="https //en.wikipedia.org/wiki/Cystic_fibrosis_transmembrane_conductance_regulator"; 
# eggNOG	COG1132	LUCA
# eggNOG	KOG0054	Eukaryota
BLAST	swissprot:CFTR_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CFTR_HUMAN
BioCyc	MetaCyc:HS00075-MONOMER	http://biocyc.org/getid?id=MetaCyc:HS00075-MONOMER
BioCyc	ZFISH:HS00075-MONOMER	http://biocyc.org/getid?id=ZFISH:HS00075-MONOMER
COXPRESdb	1080	http://coxpresdb.jp/data/gene/1080.shtml
CleanEx	HS_CFTR	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CFTR
DIP	DIP-32788N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-32788N
DOI	10.1002/(SICI)1097-0134(19980215)30:3<275::AID-PROT7>3.3.CO	http://dx.doi.org/10.1002/(SICI)1097-0134(19980215)30:3<275::AID-PROT7>3.3.CO
DOI	10.1002/(SICI)1098-1004(1996)7:2<151::AID-HUMU10>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1996)7:2<151::AID-HUMU10>3.0.CO
DOI	10.1002/(SICI)1098-1004(1996)7:4<375::AID-HUMU17>3.3.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1996)7:4<375::AID-HUMU17>3.3.CO
DOI	10.1002/(SICI)1098-1004(1996)7:4<376::AID-HUMU18>3.3.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1996)7:4<376::AID-HUMU18>3.3.CO
DOI	10.1002/(SICI)1098-1004(1996)8:4<340::AID-HUMU7>3.3.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1996)8:4<340::AID-HUMU7>3.3.CO
DOI	10.1002/(SICI)1098-1004(1997)10:1<86::AID-HUMU15>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1997)10:1<86::AID-HUMU15>3.0.CO
DOI	10.1002/(SICI)1098-1004(1997)10:5<387::AID-HUMU9>3.3.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1997)10:5<387::AID-HUMU9>3.3.CO
DOI	10.1002/(SICI)1098-1004(1997)10:6<436::AID-HUMU4>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1997)10:6<436::AID-HUMU4>3.0.CO
DOI	10.1002/(SICI)1098-1004(1997)9:2<183::AID-HUMU13>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1997)9:2<183::AID-HUMU13>3.0.CO
DOI	10.1002/(SICI)1098-1004(1997)9:4<368::AID-HUMU13>3.3.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1997)9:4<368::AID-HUMU13>3.3.CO
DOI	10.1002/(SICI)1098-1004(1998)11:2<152::AID-HUMU8>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1998)11:2<152::AID-HUMU8>3.0.CO
DOI	10.1002/(SICI)1098-1004(1999)13:2<173::AID-HUMU20>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1999)13:2<173::AID-HUMU20>3.0.CO
DOI	10.1002/humu.1380010304	http://dx.doi.org/10.1002/humu.1380010304
DOI	10.1002/humu.1380020511	http://dx.doi.org/10.1002/humu.1380020511
DOI	10.1002/humu.1380030308	http://dx.doi.org/10.1002/humu.1380030308
DOI	10.1002/humu.1380030412	http://dx.doi.org/10.1002/humu.1380030412
DOI	10.1002/humu.1380050106	http://dx.doi.org/10.1002/humu.1380050106
DOI	10.1002/humu.1380050304	http://dx.doi.org/10.1002/humu.1380050304
DOI	10.1002/humu.1380060216	http://dx.doi.org/10.1002/humu.1380060216
DOI	10.1002/pro.5560061117	http://dx.doi.org/10.1002/pro.5560061117
DOI	10.1006/geno.1993.1183	http://dx.doi.org/10.1006/geno.1993.1183
DOI	10.1006/geno.1994.1290	http://dx.doi.org/10.1006/geno.1994.1290
DOI	10.1007/BF00202817	http://dx.doi.org/10.1007/BF00202817
DOI	10.1007/BF00210305	http://dx.doi.org/10.1007/BF00210305
DOI	10.1007/BF00210414	http://dx.doi.org/10.1007/BF00210414
DOI	10.1007/BF00211022	http://dx.doi.org/10.1007/BF00211022
DOI	10.1007/s00418-011-0904-1	http://dx.doi.org/10.1007/s00418-011-0904-1
DOI	10.1007/s004390050683	http://dx.doi.org/10.1007/s004390050683
DOI	10.1007/s004390050897	http://dx.doi.org/10.1007/s004390050897
DOI	10.1016/0888-7543(91)90503-7	http://dx.doi.org/10.1016/0888-7543(91)90503-7
DOI	10.1016/0888-7543(91)90510-L	http://dx.doi.org/10.1016/0888-7543(91)90510-L
DOI	10.1016/S0022-3476(95)70310-1	http://dx.doi.org/10.1016/S0022-3476(95)70310-1
DOI	10.1016/S0890-8508(95)80038-7	http://dx.doi.org/10.1016/S0890-8508(95)80038-7
DOI	10.1038/346366a0	http://dx.doi.org/10.1038/346366a0
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1038/nature07485	http://dx.doi.org/10.1038/nature07485
DOI	10.1073/pnas.87.21.8447	http://dx.doi.org/10.1073/pnas.87.21.8447
DOI	10.1074/jbc.C100154200	http://dx.doi.org/10.1074/jbc.C100154200
DOI	10.1074/jbc.M109.001685	http://dx.doi.org/10.1074/jbc.M109.001685
DOI	10.1074/jbc.M110177200	http://dx.doi.org/10.1074/jbc.M110177200
DOI	10.1074/jbc.M113.470500	http://dx.doi.org/10.1074/jbc.M113.470500
DOI	10.1074/jbc.M201862200	http://dx.doi.org/10.1074/jbc.M201862200
DOI	10.1074/jbc.M403141200	http://dx.doi.org/10.1074/jbc.M403141200
DOI	10.1074/jbc.M608531200	http://dx.doi.org/10.1074/jbc.M608531200
DOI	10.1074/jbc.M910165199	http://dx.doi.org/10.1074/jbc.M910165199
DOI	10.1086/301681	http://dx.doi.org/10.1086/301681
DOI	10.1093/hmg/1.1.11	http://dx.doi.org/10.1093/hmg/1.1.11
DOI	10.1093/hmg/1.2.123	http://dx.doi.org/10.1093/hmg/1.2.123
DOI	10.1093/hmg/1.6.439	http://dx.doi.org/10.1093/hmg/1.6.439
DOI	10.1093/hmg/1.6.441	http://dx.doi.org/10.1093/hmg/1.6.441
DOI	10.1093/hmg/2.1.79	http://dx.doi.org/10.1093/hmg/2.1.79
DOI	10.1093/hmg/2.10.1741	http://dx.doi.org/10.1093/hmg/2.10.1741
DOI	10.1093/hmg/3.6.1001	http://dx.doi.org/10.1093/hmg/3.6.1001
DOI	10.1093/hmg/3.6.999	http://dx.doi.org/10.1093/hmg/3.6.999
DOI	10.1093/hmg/7.11.1761	http://dx.doi.org/10.1093/hmg/7.11.1761
DOI	10.1093/hmg/ddg215	http://dx.doi.org/10.1093/hmg/ddg215
DOI	10.1093/hmg/ddr558	http://dx.doi.org/10.1093/hmg/ddr558
DOI	10.1093/protein/gzr054	http://dx.doi.org/10.1093/protein/gzr054
DOI	10.1113/jphysiol.2002.035790	http://dx.doi.org/10.1113/jphysiol.2002.035790
DOI	10.1126/science.1083423	http://dx.doi.org/10.1126/science.1083423
DOI	10.1126/science.2475911	http://dx.doi.org/10.1126/science.2475911
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1152/ajpcell.00227.2002	http://dx.doi.org/10.1152/ajpcell.00227.2002
DOI	10.1159/000335765	http://dx.doi.org/10.1159/000335765
DisProt	DP00012	http://www.disprot.org/protein.php?id=DP00012
DrugBank	DB00887	http://www.drugbank.ca/drugs/DB00887
DrugBank	DB01016	http://www.drugbank.ca/drugs/DB01016
DrugBank	DB01050	http://www.drugbank.ca/drugs/DB01050
DrugBank	DB04941	http://www.drugbank.ca/drugs/DB04941
DrugBank	DB08820	http://www.drugbank.ca/drugs/DB08820
EC_number	EC:3.6.3.49	http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.49
EMBL	AC000061	http://www.ebi.ac.uk/ena/data/view/AC000061
EMBL	AC000111	http://www.ebi.ac.uk/ena/data/view/AC000111
EMBL	CH236947	http://www.ebi.ac.uk/ena/data/view/CH236947
EMBL	DQ354388	http://www.ebi.ac.uk/ena/data/view/DQ354388
EMBL	DQ354389	http://www.ebi.ac.uk/ena/data/view/DQ354389
EMBL	DQ354390	http://www.ebi.ac.uk/ena/data/view/DQ354390
EMBL	DQ354391	http://www.ebi.ac.uk/ena/data/view/DQ354391
EMBL	DQ356258	http://www.ebi.ac.uk/ena/data/view/DQ356258
EMBL	DQ356259	http://www.ebi.ac.uk/ena/data/view/DQ356259
EMBL	DQ356261	http://www.ebi.ac.uk/ena/data/view/DQ356261
EMBL	DQ356262	http://www.ebi.ac.uk/ena/data/view/DQ356262
EMBL	DQ356263	http://www.ebi.ac.uk/ena/data/view/DQ356263
EMBL	DQ356264	http://www.ebi.ac.uk/ena/data/view/DQ356264
EMBL	DQ388128	http://www.ebi.ac.uk/ena/data/view/DQ388128
EMBL	DQ388129	http://www.ebi.ac.uk/ena/data/view/DQ388129
EMBL	DQ388131	http://www.ebi.ac.uk/ena/data/view/DQ388131
EMBL	DQ388132	http://www.ebi.ac.uk/ena/data/view/DQ388132
EMBL	DQ388133	http://www.ebi.ac.uk/ena/data/view/DQ388133
EMBL	DQ388134	http://www.ebi.ac.uk/ena/data/view/DQ388134
EMBL	DQ388135	http://www.ebi.ac.uk/ena/data/view/DQ388135
EMBL	DQ388138	http://www.ebi.ac.uk/ena/data/view/DQ388138
EMBL	DQ388139	http://www.ebi.ac.uk/ena/data/view/DQ388139
EMBL	DQ388140	http://www.ebi.ac.uk/ena/data/view/DQ388140
EMBL	DQ388141	http://www.ebi.ac.uk/ena/data/view/DQ388141
EMBL	DQ388142	http://www.ebi.ac.uk/ena/data/view/DQ388142
EMBL	DQ388143	http://www.ebi.ac.uk/ena/data/view/DQ388143
EMBL	DQ388145	http://www.ebi.ac.uk/ena/data/view/DQ388145
EMBL	M28668	http://www.ebi.ac.uk/ena/data/view/M28668
EMBL	M55106	http://www.ebi.ac.uk/ena/data/view/M55106
EMBL	M55107	http://www.ebi.ac.uk/ena/data/view/M55107
EMBL	M55108	http://www.ebi.ac.uk/ena/data/view/M55108
EMBL	M55110	http://www.ebi.ac.uk/ena/data/view/M55110
EMBL	M55111	http://www.ebi.ac.uk/ena/data/view/M55111
EMBL	M55112	http://www.ebi.ac.uk/ena/data/view/M55112
EMBL	M55113	http://www.ebi.ac.uk/ena/data/view/M55113
EMBL	M55114	http://www.ebi.ac.uk/ena/data/view/M55114
EMBL	M55115	http://www.ebi.ac.uk/ena/data/view/M55115
EMBL	M55116	http://www.ebi.ac.uk/ena/data/view/M55116
EMBL	M55117	http://www.ebi.ac.uk/ena/data/view/M55117
EMBL	M55118	http://www.ebi.ac.uk/ena/data/view/M55118
EMBL	M55119	http://www.ebi.ac.uk/ena/data/view/M55119
EMBL	M55120	http://www.ebi.ac.uk/ena/data/view/M55120
EMBL	M55121	http://www.ebi.ac.uk/ena/data/view/M55121
EMBL	M55122	http://www.ebi.ac.uk/ena/data/view/M55122
EMBL	M55123	http://www.ebi.ac.uk/ena/data/view/M55123
EMBL	M55124	http://www.ebi.ac.uk/ena/data/view/M55124
EMBL	M55125	http://www.ebi.ac.uk/ena/data/view/M55125
EMBL	M55126	http://www.ebi.ac.uk/ena/data/view/M55126
EMBL	M55127	http://www.ebi.ac.uk/ena/data/view/M55127
EMBL	M55128	http://www.ebi.ac.uk/ena/data/view/M55128
EMBL	M55129	http://www.ebi.ac.uk/ena/data/view/M55129
EMBL	M55130	http://www.ebi.ac.uk/ena/data/view/M55130
EMBL	M55131	http://www.ebi.ac.uk/ena/data/view/M55131
EMBL	M65196	http://www.ebi.ac.uk/ena/data/view/M65196
EMBL	M65197	http://www.ebi.ac.uk/ena/data/view/M65197
ENZYME	3.6.3.49	http://enzyme.expasy.org/EC/3.6.3.49
Ensembl	ENST00000003084	http://www.ensembl.org/id/ENST00000003084
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005769	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005769
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0030660	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030660
GO_component	GO:0031901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031901
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GO_component	GO:0055037	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055037
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005224	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005224
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0005260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005260
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0015106	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015106
GO_function	GO:0015108	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015108
GO_function	GO:0017081	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017081
GO_function	GO:0019869	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019869
GO_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GO_function	GO:0030165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030165
GO_function	GO:0043225	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043225
GO_process	GO:0006695	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006695
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006904	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006904
GO_process	GO:0007585	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007585
GO_process	GO:0030301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030301
GO_process	GO:0035774	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035774
GO_process	GO:0045921	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045921
GO_process	GO:0048240	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048240
GO_process	GO:0051454	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051454
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GO_process	GO:0060081	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060081
GO_process	GO:0071320	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071320
GO_process	GO:1902161	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902161
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GO_process	GO:1902943	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902943
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0021700	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021700
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	CFTR	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CFTR
GeneID	1080	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1080
GeneTree	ENSGT00860000133687	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00860000133687
HGNC	HGNC:1884	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1884
HOVERGEN	HBG004169	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004169&db=HOVERGEN
HPA	CAB001951	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB001951
HPA	HPA021939	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA021939
InParanoid	P13569	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P13569
IntAct	P13569	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P13569*
IntEnz	3.6.3.49	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.49
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR009147	http://www.ebi.ac.uk/interpro/entry/IPR009147
InterPro	IPR011527	http://www.ebi.ac.uk/interpro/entry/IPR011527
InterPro	IPR017871	http://www.ebi.ac.uk/interpro/entry/IPR017871
InterPro	IPR025837	http://www.ebi.ac.uk/interpro/entry/IPR025837
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	1080	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1080
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00218	http://www.genome.jp/dbget-bin/www_bget?H00218
KEGG_Disease	H00933	http://www.genome.jp/dbget-bin/www_bget?H00933
KEGG_Disease	H01033	http://www.genome.jp/dbget-bin/www_bget?H01033
KEGG_Gene	hsa:1080	http://www.genome.jp/dbget-bin/www_bget?hsa:1080
KEGG_Orthology	KO:K05031	http://www.genome.jp/dbget-bin/www_bget?KO:K05031
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
KEGG_Pathway	ko04971	http://www.genome.jp/kegg-bin/show_pathway?ko04971
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
KEGG_Pathway	ko05110	http://www.genome.jp/kegg-bin/show_pathway?ko05110
MIM	219700	http://www.ncbi.nlm.nih.gov/omim/219700
MIM	277180	http://www.ncbi.nlm.nih.gov/omim/277180
MIM	602421	http://www.ncbi.nlm.nih.gov/omim/602421
MINT	MINT-148539	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-148539
OMA	NALRRCF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NALRRCF
Orphanet	399805	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=399805
Orphanet	48	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=48
Orphanet	586	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=586
Orphanet	60033	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=60033
Orphanet	676	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=676
OrthoDB	EOG091G00K4	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00K4
PANTHER	PTHR24223:SF19	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24223:SF19
PDB	1NBD	http://www.ebi.ac.uk/pdbe-srv/view/entry/1NBD
PDB	1XMI	http://www.ebi.ac.uk/pdbe-srv/view/entry/1XMI
PDB	1XMJ	http://www.ebi.ac.uk/pdbe-srv/view/entry/1XMJ
PDB	2BBO	http://www.ebi.ac.uk/pdbe-srv/view/entry/2BBO
PDB	2BBS	http://www.ebi.ac.uk/pdbe-srv/view/entry/2BBS
PDB	2BBT	http://www.ebi.ac.uk/pdbe-srv/view/entry/2BBT
PDB	2LOB	http://www.ebi.ac.uk/pdbe-srv/view/entry/2LOB
PDB	2PZE	http://www.ebi.ac.uk/pdbe-srv/view/entry/2PZE
PDB	2PZF	http://www.ebi.ac.uk/pdbe-srv/view/entry/2PZF
PDB	2PZG	http://www.ebi.ac.uk/pdbe-srv/view/entry/2PZG
PDB	3GD7	http://www.ebi.ac.uk/pdbe-srv/view/entry/3GD7
PDB	3ISW	http://www.ebi.ac.uk/pdbe-srv/view/entry/3ISW
PDB	4WZ6	http://www.ebi.ac.uk/pdbe-srv/view/entry/4WZ6
PDB	5D2D	http://www.ebi.ac.uk/pdbe-srv/view/entry/5D2D
PDB	5D3E	http://www.ebi.ac.uk/pdbe-srv/view/entry/5D3E
PDBsum	1NBD	http://www.ebi.ac.uk/pdbsum/1NBD
PDBsum	1XMI	http://www.ebi.ac.uk/pdbsum/1XMI
PDBsum	1XMJ	http://www.ebi.ac.uk/pdbsum/1XMJ
PDBsum	2BBO	http://www.ebi.ac.uk/pdbsum/2BBO
PDBsum	2BBS	http://www.ebi.ac.uk/pdbsum/2BBS
PDBsum	2BBT	http://www.ebi.ac.uk/pdbsum/2BBT
PDBsum	2LOB	http://www.ebi.ac.uk/pdbsum/2LOB
PDBsum	2PZE	http://www.ebi.ac.uk/pdbsum/2PZE
PDBsum	2PZF	http://www.ebi.ac.uk/pdbsum/2PZF
PDBsum	2PZG	http://www.ebi.ac.uk/pdbsum/2PZG
PDBsum	3GD7	http://www.ebi.ac.uk/pdbsum/3GD7
PDBsum	3ISW	http://www.ebi.ac.uk/pdbsum/3ISW
PDBsum	4WZ6	http://www.ebi.ac.uk/pdbsum/4WZ6
PDBsum	5D2D	http://www.ebi.ac.uk/pdbsum/5D2D
PDBsum	5D3E	http://www.ebi.ac.uk/pdbsum/5D3E
PRINTS	PR01851	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01851
PROSITE	PS00211	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PROSITE	PS50929	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929
PSORT	swissprot:CFTR_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CFTR_HUMAN
PSORT-B	swissprot:CFTR_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CFTR_HUMAN
PSORT2	swissprot:CFTR_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CFTR_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
Pfam	PF00664	http://pfam.xfam.org/family/PF00664
Pfam	PF14396	http://pfam.xfam.org/family/PF14396
PharmGKB	PA109	http://www.pharmgkb.org/do/serve?objId=PA109&objCls=Gene
Phobius	swissprot:CFTR_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CFTR_HUMAN
PhylomeDB	P13569	http://phylomedb.org/?seqid=P13569
ProteinModelPortal	P13569	http://www.proteinmodelportal.org/query/uniprot/P13569
PubMed	10094564	http://www.ncbi.nlm.nih.gov/pubmed/10094564
PubMed	10651488	http://www.ncbi.nlm.nih.gov/pubmed/10651488
PubMed	10766763	http://www.ncbi.nlm.nih.gov/pubmed/10766763
PubMed	11304524	http://www.ncbi.nlm.nih.gov/pubmed/11304524
PubMed	11707463	http://www.ncbi.nlm.nih.gov/pubmed/11707463
PubMed	12403779	http://www.ncbi.nlm.nih.gov/pubmed/12403779
PubMed	12519745	http://www.ncbi.nlm.nih.gov/pubmed/12519745
PubMed	12588899	http://www.ncbi.nlm.nih.gov/pubmed/12588899
PubMed	12690205	http://www.ncbi.nlm.nih.gov/pubmed/12690205
PubMed	1284466	http://www.ncbi.nlm.nih.gov/pubmed/1284466
PubMed	1284468	http://www.ncbi.nlm.nih.gov/pubmed/1284468
PubMed	1284529	http://www.ncbi.nlm.nih.gov/pubmed/1284529
PubMed	1284530	http://www.ncbi.nlm.nih.gov/pubmed/1284530
PubMed	1284534	http://www.ncbi.nlm.nih.gov/pubmed/1284534
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	12913074	http://www.ncbi.nlm.nih.gov/pubmed/12913074
PubMed	1377674	http://www.ncbi.nlm.nih.gov/pubmed/1377674
PubMed	1378801	http://www.ncbi.nlm.nih.gov/pubmed/1378801
PubMed	15247260	http://www.ncbi.nlm.nih.gov/pubmed/15247260
PubMed	1695717	http://www.ncbi.nlm.nih.gov/pubmed/1695717
PubMed	1710598	http://www.ncbi.nlm.nih.gov/pubmed/1710598
PubMed	1710600	http://www.ncbi.nlm.nih.gov/pubmed/1710600
PubMed	17462998	http://www.ncbi.nlm.nih.gov/pubmed/17462998
PubMed	18987736	http://www.ncbi.nlm.nih.gov/pubmed/18987736
PubMed	19398555	http://www.ncbi.nlm.nih.gov/pubmed/19398555
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	22119790	http://www.ncbi.nlm.nih.gov/pubmed/22119790
PubMed	22121115	http://www.ncbi.nlm.nih.gov/pubmed/22121115
PubMed	22178883	http://www.ncbi.nlm.nih.gov/pubmed/22178883
PubMed	22207244	http://www.ncbi.nlm.nih.gov/pubmed/22207244
PubMed	2236053	http://www.ncbi.nlm.nih.gov/pubmed/2236053
PubMed	24019521	http://www.ncbi.nlm.nih.gov/pubmed/24019521
PubMed	2475911	http://www.ncbi.nlm.nih.gov/pubmed/2475911
PubMed	7504969	http://www.ncbi.nlm.nih.gov/pubmed/7504969
PubMed	7505694	http://www.ncbi.nlm.nih.gov/pubmed/7505694
PubMed	7513296	http://www.ncbi.nlm.nih.gov/pubmed/7513296
PubMed	7517264	http://www.ncbi.nlm.nih.gov/pubmed/7517264
PubMed	7518437	http://www.ncbi.nlm.nih.gov/pubmed/7518437
PubMed	7520022	http://www.ncbi.nlm.nih.gov/pubmed/7520022
PubMed	7522211	http://www.ncbi.nlm.nih.gov/pubmed/7522211
PubMed	7524909	http://www.ncbi.nlm.nih.gov/pubmed/7524909
PubMed	7524913	http://www.ncbi.nlm.nih.gov/pubmed/7524913
PubMed	7525450	http://www.ncbi.nlm.nih.gov/pubmed/7525450
PubMed	7529962	http://www.ncbi.nlm.nih.gov/pubmed/7529962
PubMed	7537150	http://www.ncbi.nlm.nih.gov/pubmed/7537150
PubMed	7539342	http://www.ncbi.nlm.nih.gov/pubmed/7539342
PubMed	7541273	http://www.ncbi.nlm.nih.gov/pubmed/7541273
PubMed	7541510	http://www.ncbi.nlm.nih.gov/pubmed/7541510
PubMed	7543567	http://www.ncbi.nlm.nih.gov/pubmed/7543567
PubMed	7544319	http://www.ncbi.nlm.nih.gov/pubmed/7544319
PubMed	7581407	http://www.ncbi.nlm.nih.gov/pubmed/7581407
PubMed	7680525	http://www.ncbi.nlm.nih.gov/pubmed/7680525
PubMed	7683628	http://www.ncbi.nlm.nih.gov/pubmed/7683628
PubMed	7683954	http://www.ncbi.nlm.nih.gov/pubmed/7683954
PubMed	8081395	http://www.ncbi.nlm.nih.gov/pubmed/8081395
PubMed	8522333	http://www.ncbi.nlm.nih.gov/pubmed/8522333
PubMed	8723693	http://www.ncbi.nlm.nih.gov/pubmed/8723693
PubMed	8723695	http://www.ncbi.nlm.nih.gov/pubmed/8723695
PubMed	8800923	http://www.ncbi.nlm.nih.gov/pubmed/8800923
PubMed	8829633	http://www.ncbi.nlm.nih.gov/pubmed/8829633
PubMed	8956039	http://www.ncbi.nlm.nih.gov/pubmed/8956039
PubMed	9067761	http://www.ncbi.nlm.nih.gov/pubmed/9067761
PubMed	9101301	http://www.ncbi.nlm.nih.gov/pubmed/9101301
PubMed	9222768	http://www.ncbi.nlm.nih.gov/pubmed/9222768
PubMed	9375855	http://www.ncbi.nlm.nih.gov/pubmed/9375855
PubMed	9385646	http://www.ncbi.nlm.nih.gov/pubmed/9385646
PubMed	9401006	http://www.ncbi.nlm.nih.gov/pubmed/9401006
PubMed	9443874	http://www.ncbi.nlm.nih.gov/pubmed/9443874
PubMed	9452048	http://www.ncbi.nlm.nih.gov/pubmed/9452048
PubMed	9452054	http://www.ncbi.nlm.nih.gov/pubmed/9452054
PubMed	9452073	http://www.ncbi.nlm.nih.gov/pubmed/9452073
PubMed	9482579	http://www.ncbi.nlm.nih.gov/pubmed/9482579
PubMed	9517543	http://www.ncbi.nlm.nih.gov/pubmed/9517543
PubMed	9521595	http://www.ncbi.nlm.nih.gov/pubmed/9521595
PubMed	9554753	http://www.ncbi.nlm.nih.gov/pubmed/9554753
PubMed	9736778	http://www.ncbi.nlm.nih.gov/pubmed/9736778
PubMed	9921909	http://www.ncbi.nlm.nih.gov/pubmed/9921909
Reactome	R-HSA-382556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-382556
Reactome	R-HSA-5627083	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5627083
Reactome	R-HSA-5678895	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5678895
Reactome	R-HSA-5689880	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5689880
Reactome	R-HSA-8856825	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8856825
Reactome	R-HSA-8856828	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8856828
RefSeq	NP_000483	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000483
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	P13569	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P13569
STRING	9606.ENSP00000003084	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000003084&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
SUPFAM	SSF90123	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123
TCDB	3.A.1.202	http://www.tcdb.org/search/result.php?tc=3.A.1.202
TIGRFAMs	TIGR01271	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01271
UCSC	uc003vjd	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003vjd&org=rat
UniGene	Hs.489786	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.489786
UniGene	Hs.621460	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.621460
UniGene	Hs.661104	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.661104
UniProtKB	CFTR_HUMAN	http://www.uniprot.org/uniprot/CFTR_HUMAN
UniProtKB-AC	P13569	http://www.uniprot.org/uniprot/P13569
charge	swissprot:CFTR_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CFTR_HUMAN
eggNOG	COG1132	http://eggnogapi.embl.de/nog_data/html/tree/COG1132
eggNOG	KOG0054	http://eggnogapi.embl.de/nog_data/html/tree/KOG0054
epestfind	swissprot:CFTR_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CFTR_HUMAN
garnier	swissprot:CFTR_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CFTR_HUMAN
helixturnhelix	swissprot:CFTR_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CFTR_HUMAN
hmoment	swissprot:CFTR_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CFTR_HUMAN
iep	swissprot:CFTR_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CFTR_HUMAN
inforesidue	swissprot:CFTR_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CFTR_HUMAN
neXtProt	NX_P13569	http://www.nextprot.org/db/entry/NX_P13569
octanol	swissprot:CFTR_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CFTR_HUMAN
pepcoil	swissprot:CFTR_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CFTR_HUMAN
pepdigest	swissprot:CFTR_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CFTR_HUMAN
pepinfo	swissprot:CFTR_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CFTR_HUMAN
pepnet	swissprot:CFTR_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CFTR_HUMAN
pepstats	swissprot:CFTR_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CFTR_HUMAN
pepwheel	swissprot:CFTR_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CFTR_HUMAN
pepwindow	swissprot:CFTR_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CFTR_HUMAN
sigcleave	swissprot:CFTR_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CFTR_HUMAN
## Database	ID	URL or Descriptions
# AltName	TOM70_HUMAN	Mitochondrial precursor proteins import receptor
# AltName	TOM70_HUMAN	Translocase of outer membrane 70 kDa subunit
# AltName	Translocase of outer mitochondrial membrane protein 70 {ECO:0000312|HGNC	HGNC:11985}
# BioGrid	115201	33
# ChiTaRS	TOMM70A	human
# Ensembl	ENST00000284320	ENSP00000284320; ENSG00000154174
# FUNCTION	TOM70_HUMAN	Receptor that accelerates the import of all mitochondrial precursor proteins. {ECO 0000250}. 
# GO_component	GO:0005739	mitochondrion; IDA:HPA.
# GO_component	GO:0005741	mitochondrial outer membrane; TAS:Reactome.
# GO_component	GO:0005742	mitochondrial outer membrane translocase complex; TAS:BHF-UCL.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0008320	protein transmembrane transporter activity; TAS:BHF-UCL.
# GO_process	GO:0006626	protein targeting to mitochondrion; TAS:BHF-UCL.
# GO_process	GO:0016236	macroautophagy; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006605	protein targeting
# GOslim_process	GO:0006914	autophagy
# Gene3D	1.25.40.10	-; 2.
# Genevisible	O94826	HS
# HGNC	HGNC:11985	TOMM70
# IntAct	O94826	10
# InterPro	IPR001440	TPR_1
# InterPro	IPR011990	TPR-like_helical_dom
# InterPro	IPR013026	TPR-contain_dom
# InterPro	IPR019734	TPR_repeat
# MIM	606081	gene
# Organism	TOM70_HUMAN	Homo sapiens (Human)
# PROSITE	PS50005	TPR; 7
# PROSITE	PS50293	TPR_REGION
# Pfam	PF00515	TPR_1
# Pfam	PF13181	TPR_8; 4
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-1268020	Mitochondrial protein import
# Reactome	R-HSA-5205685	Pink/Parkin Mediated Mitophagy
# Reactome	R-HSA-5689880	Ub-specific processing proteases
# RecName	TOM70_HUMAN	Mitochondrial import receptor subunit TOM70
# RefSeq	NP_055635	NM_014820.4
# SEQUENCE CAUTION	Sequence=BAA34439.2; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the Tom70 family. {ECO	0000305}. 
# SIMILARITY	Contains 10 TPR repeats. {ECO:0000255|PROSITE- ProRule	PRU00339}. 
# SMART	SM00028	TPR; 10
# SUBCELLULAR LOCATION	TOM70_HUMAN	Mitochondrion outer membrane {ECO 0000250}; Single-pass membrane protein {ECO 0000250}. 
# SUBUNIT	Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with CAPN8 (By similarity). {ECO	0000250}. 
# SUPFAM	SSF48452	SSF48452; 2
# UCSC	uc003dtw	human
# eggNOG	ENOG410YVNZ	LUCA
# eggNOG	KOG0547	Eukaryota
BLAST	swissprot:TOM70_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TOM70_HUMAN
BioCyc	ZFISH:ENSG00000154174-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000154174-MONOMER
COXPRESdb	9868	http://coxpresdb.jp/data/gene/9868.shtml
CleanEx	HS_TOMM70A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TOMM70A
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.bbrc.2008.02.150	http://dx.doi.org/10.1016/j.bbrc.2008.02.150
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr0704130	http://dx.doi.org/10.1021/pr0704130
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1074/mcp.M111.015131	http://dx.doi.org/10.1074/mcp.M111.015131
DOI	10.1074/mcp.O113.027870	http://dx.doi.org/10.1074/mcp.O113.027870
DOI	10.1093/dnares/5.5.277	http://dx.doi.org/10.1093/dnares/5.5.277
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AB018262	http://www.ebi.ac.uk/ena/data/view/AB018262
EMBL	BC003633	http://www.ebi.ac.uk/ena/data/view/BC003633
EMBL	BC052994	http://www.ebi.ac.uk/ena/data/view/BC052994
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
Ensembl	ENST00000284320	http://www.ensembl.org/id/ENST00000284320
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005741	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005741
GO_component	GO:0005742	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005742
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0008320	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008320
GO_process	GO:0006626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006626
GO_process	GO:0016236	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016236
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605
GOslim_process	GO:0006914	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006914
Gene3D	1.25.40.10	http://www.cathdb.info/version/latest/superfamily/1.25.40.10
GeneCards	TOMM70A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TOMM70A
GeneID	9868	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9868
GeneTree	ENSGT00860000133798	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00860000133798
HGNC	HGNC:11985	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11985
HOGENOM	HOG000264237	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264237&db=HOGENOM6
HOVERGEN	HBG062335	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG062335&db=HOVERGEN
HPA	CAB017156	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB017156
HPA	HPA014589	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014589
HPA	HPA048020	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA048020
InParanoid	O94826	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O94826
IntAct	O94826	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O94826*
InterPro	IPR001440	http://www.ebi.ac.uk/interpro/entry/IPR001440
InterPro	IPR011990	http://www.ebi.ac.uk/interpro/entry/IPR011990
InterPro	IPR013026	http://www.ebi.ac.uk/interpro/entry/IPR013026
InterPro	IPR019734	http://www.ebi.ac.uk/interpro/entry/IPR019734
Jabion	9868	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9868
KEGG_Gene	hsa:9868	http://www.genome.jp/dbget-bin/www_bget?hsa:9868
MIM	606081	http://www.ncbi.nlm.nih.gov/omim/606081
MINT	MINT-3002394	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3002394
OMA	KWTEVAQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KWTEVAQ
OrthoDB	EOG091G0CYZ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0CYZ
PROSITE	PS50005	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50005
PROSITE	PS50293	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50293
PSORT	swissprot:TOM70_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TOM70_HUMAN
PSORT-B	swissprot:TOM70_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TOM70_HUMAN
PSORT2	swissprot:TOM70_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TOM70_HUMAN
Pfam	PF00515	http://pfam.xfam.org/family/PF00515
Pfam	PF13181	http://pfam.xfam.org/family/PF13181
PharmGKB	PA36669	http://www.pharmgkb.org/do/serve?objId=PA36669&objCls=Gene
Phobius	swissprot:TOM70_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TOM70_HUMAN
PhylomeDB	O94826	http://phylomedb.org/?seqid=O94826
ProteinModelPortal	O94826	http://www.proteinmodelportal.org/query/uniprot/O94826
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	18088087	http://www.ncbi.nlm.nih.gov/pubmed/18088087
PubMed	18331822	http://www.ncbi.nlm.nih.gov/pubmed/18331822
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	22223895	http://www.ncbi.nlm.nih.gov/pubmed/22223895
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24129315	http://www.ncbi.nlm.nih.gov/pubmed/24129315
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	9872452	http://www.ncbi.nlm.nih.gov/pubmed/9872452
Reactome	R-HSA-1268020	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1268020
Reactome	R-HSA-5205685	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5205685
Reactome	R-HSA-5689880	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5689880
RefSeq	NP_055635	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055635
SMART	SM00028	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00028
SMR	O94826	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O94826
STRING	9606.ENSP00000284320	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000284320&targetmode=cogs
SUPFAM	SSF48452	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48452
UCSC	uc003dtw	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003dtw&org=rat
UniGene	Hs.227253	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.227253
UniProtKB	TOM70_HUMAN	http://www.uniprot.org/uniprot/TOM70_HUMAN
UniProtKB-AC	O94826	http://www.uniprot.org/uniprot/O94826
charge	swissprot:TOM70_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TOM70_HUMAN
eggNOG	ENOG410YVNZ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YVNZ
eggNOG	KOG0547	http://eggnogapi.embl.de/nog_data/html/tree/KOG0547
epestfind	swissprot:TOM70_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TOM70_HUMAN
garnier	swissprot:TOM70_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TOM70_HUMAN
helixturnhelix	swissprot:TOM70_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TOM70_HUMAN
hmoment	swissprot:TOM70_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TOM70_HUMAN
iep	swissprot:TOM70_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TOM70_HUMAN
inforesidue	swissprot:TOM70_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TOM70_HUMAN
neXtProt	NX_O94826	http://www.nextprot.org/db/entry/NX_O94826
octanol	swissprot:TOM70_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TOM70_HUMAN
pepcoil	swissprot:TOM70_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TOM70_HUMAN
pepdigest	swissprot:TOM70_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TOM70_HUMAN
pepinfo	swissprot:TOM70_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TOM70_HUMAN
pepnet	swissprot:TOM70_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TOM70_HUMAN
pepstats	swissprot:TOM70_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TOM70_HUMAN
pepwheel	swissprot:TOM70_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TOM70_HUMAN
pepwindow	swissprot:TOM70_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TOM70_HUMAN
sigcleave	swissprot:TOM70_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TOM70_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ARFG3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NP61-1; Sequence=Displayed; Name=2; IsoId=Q9NP61-2; Sequence=VSP_046888; Note=Gene prediction based on EST data.; 
# BioGrid	117668	19
# CAUTION	Was originally termed ARFGAP1. {ECO:0000305|PubMed	10704287}. 
# CCDS	CCDS14042	-. [Q9NP61-1]
# CCDS	CCDS46722	-. [Q9NP61-2]
# ChiTaRS	ARFGAP3	human
# DEVELOPMENTAL STAGE	ARFG3_HUMAN	Expressed at higher level in adult thymus, brain and lung, than in corresponding fetal tissues. Expressed at lower level in spleen, heart, kidney and liver during development. 
# ENZYME REGULATION	GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2). {ECO:0000269|PubMed	11172815}. 
# Ensembl	ENST00000263245	ENSP00000263245; ENSG00000242247. [Q9NP61-1]
# Ensembl	ENST00000437119	ENSP00000388791; ENSG00000242247. [Q9NP61-2]
# ExpressionAtlas	Q9NP61	baseline and differential
# FUNCTION	ARFG3_HUMAN	GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO 0000269|PubMed 11172815}. 
# GO_component	GO:0000139	Golgi membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0005794	Golgi apparatus; IDA:HPA.
# GO_component	GO:0005829	cytosol; IDA:UniProtKB.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_function	GO:0005096	GTPase activator activity; IDA:UniProtKB.
# GO_function	GO:0008565	protein transporter activity; NAS:UniProtKB.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0006886	intracellular protein transport; NAS:UniProtKB.
# GO_process	GO:0006888	ER to Golgi vesicle-mediated transport; TAS:Reactome.
# GO_process	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER; TAS:Reactome.
# GO_process	GO:0009306	protein secretion; IEP:UniProtKB.
# GO_process	GO:0016192	vesicle-mediated transport; NAS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005829	cytosol
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0030234	enzyme regulator activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0016192	vesicle-mediated transport
# Genevisible	Q9NP61	HS
# HGNC	HGNC:661	ARFGAP3
# INTERACTION	ARFG3_HUMAN	Q8IUH5 ZDHHC17; NbExp=2; IntAct=EBI-2875816, EBI-524753; 
# IntAct	Q9NP61	14
# InterPro	IPR001164	ArfGAP
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Pathway	ko04144	Endocytosis
# MIM	612439	gene
# Organism	ARFG3_HUMAN	Homo sapiens (Human)
# PDB	2CRW	NMR; -; A=1-136
# PIR	T46305	T46305
# PRINTS	PR00405	REVINTRACTNG
# PROSITE	PS50115	ARFGAP
# Pfam	PF01412	ArfGap
# Proteomes	UP000005640	Chromosome 22
# Reactome	R-HSA-6807878	COPI-mediated anterograde transport
# Reactome	R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic
# RecName	ARFG3_HUMAN	ADP-ribosylation factor GTPase-activating protein 3
# RefSeq	NP_001135765	NM_001142293.1. [Q9NP61-2]
# RefSeq	NP_055385	NM_014570.4. [Q9NP61-1]
# SEQUENCE CAUTION	Sequence=BAA92076.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14236.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Contains 1 Arf-GAP domain. {ECO:0000255|PROSITE- ProRule	PRU00288}. 
# SMART	SM00105	ArfGap
# SUBCELLULAR LOCATION	ARFG3_HUMAN	Cytoplasm {ECO 0000269|PubMed 17760859}. Golgi apparatus membrane {ECO 0000269|PubMed 17760859}; Peripheral membrane protein {ECO 0000269|PubMed 17760859}; Cytoplasmic side {ECO 0000269|PubMed 17760859}. Note=Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment. 
# TISSUE SPECIFICITY	Widely expressed. Highest expression in endocrine glands (pancreas, pituitary gland, salivary gland, and prostate) and testis with a much higher expression in the testis than in the ovary. {ECO:0000269|PubMed	10704287}. 
# TopDownProteomics	Q9NP61-1	-. [Q9NP61-1]
# UCSC	uc003bdd	human. [Q9NP61-1]
# eggNOG	COG5347	LUCA
# eggNOG	KOG0706	Eukaryota
BLAST	swissprot:ARFG3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ARFG3_HUMAN
COXPRESdb	26286	http://coxpresdb.jp/data/gene/26286.shtml
CleanEx	HS_ARFGAP1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ARFGAP1
CleanEx	HS_ARFGAP3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ARFGAP3
DOI	10.1006/geno.1999.6095	http://dx.doi.org/10.1006/geno.1999.6095
DOI	10.1016/S0014-5793(01)02134-2	http://dx.doi.org/10.1016/S0014-5793(01)02134-2
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/990031	http://dx.doi.org/10.1038/990031
DOI	10.1038/nbt1046	http://dx.doi.org/10.1038/nbt1046
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1101/gr.695703	http://dx.doi.org/10.1101/gr.695703
DOI	10.1111/j.1600-0854.2007.00631.x	http://dx.doi.org/10.1111/j.1600-0854.2007.00631.x
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1186/gb-2004-5-10-r84	http://dx.doi.org/10.1186/gb-2004-5-10-r84
EMBL	AF111847	http://www.ebi.ac.uk/ena/data/view/AF111847
EMBL	AK002083	http://www.ebi.ac.uk/ena/data/view/AK002083
EMBL	AK022768	http://www.ebi.ac.uk/ena/data/view/AK022768
EMBL	AL049757	http://www.ebi.ac.uk/ena/data/view/AL049757
EMBL	AL049757	http://www.ebi.ac.uk/ena/data/view/AL049757
EMBL	AL049758	http://www.ebi.ac.uk/ena/data/view/AL049758
EMBL	AL049758	http://www.ebi.ac.uk/ena/data/view/AL049758
EMBL	AL137598	http://www.ebi.ac.uk/ena/data/view/AL137598
EMBL	AL159143	http://www.ebi.ac.uk/ena/data/view/AL159143
EMBL	BC005122	http://www.ebi.ac.uk/ena/data/view/BC005122
EMBL	CR456382	http://www.ebi.ac.uk/ena/data/view/CR456382
Ensembl	ENST00000263245	http://www.ensembl.org/id/ENST00000263245
Ensembl	ENST00000437119	http://www.ensembl.org/id/ENST00000437119
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_function	GO:0005096	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005096
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006886
GO_process	GO:0006888	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006888
GO_process	GO:0006890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006890
GO_process	GO:0009306	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009306
GO_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0030234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GeneCards	ARFGAP3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ARFGAP3
GeneID	26286	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26286
GeneTree	ENSGT00390000005436	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000005436
HGNC	HGNC:661	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:661
HOVERGEN	HBG050563	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050563&db=HOVERGEN
HPA	HPA000638	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA000638
InParanoid	Q9NP61	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NP61
IntAct	Q9NP61	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9NP61*
InterPro	IPR001164	http://www.ebi.ac.uk/interpro/entry/IPR001164
Jabion	26286	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=26286
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Gene	hsa:26286	http://www.genome.jp/dbget-bin/www_bget?hsa:26286
KEGG_Orthology	KO:K12493	http://www.genome.jp/dbget-bin/www_bget?KO:K12493
KEGG_Pathway	ko04144	http://www.genome.jp/kegg-bin/show_pathway?ko04144
MIM	612439	http://www.ncbi.nlm.nih.gov/omim/612439
OMA	WDDSADS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WDDSADS
OrthoDB	EOG091G0AS9	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0AS9
PDB	2CRW	http://www.ebi.ac.uk/pdbe-srv/view/entry/2CRW
PDBsum	2CRW	http://www.ebi.ac.uk/pdbsum/2CRW
PRINTS	PR00405	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00405
PROSITE	PS50115	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50115
PSORT	swissprot:ARFG3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ARFG3_HUMAN
PSORT-B	swissprot:ARFG3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ARFG3_HUMAN
PSORT2	swissprot:ARFG3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ARFG3_HUMAN
Pfam	PF01412	http://pfam.xfam.org/family/PF01412
PharmGKB	PA35024	http://www.pharmgkb.org/do/serve?objId=PA35024&objCls=Gene
Phobius	swissprot:ARFG3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ARFG3_HUMAN
PhylomeDB	Q9NP61	http://phylomedb.org/?seqid=Q9NP61
ProteinModelPortal	Q9NP61	http://www.proteinmodelportal.org/query/uniprot/Q9NP61
PubMed	10591208	http://www.ncbi.nlm.nih.gov/pubmed/10591208
PubMed	10704287	http://www.ncbi.nlm.nih.gov/pubmed/10704287
PubMed	11172815	http://www.ncbi.nlm.nih.gov/pubmed/11172815
PubMed	12529303	http://www.ncbi.nlm.nih.gov/pubmed/12529303
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15461802	http://www.ncbi.nlm.nih.gov/pubmed/15461802
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15592455	http://www.ncbi.nlm.nih.gov/pubmed/15592455
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	17760859	http://www.ncbi.nlm.nih.gov/pubmed/17760859
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
Reactome	R-HSA-6807878	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6807878
Reactome	R-HSA-6811434	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6811434
RefSeq	NP_001135765	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001135765
RefSeq	NP_055385	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055385
SMART	SM00105	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00105
SMR	Q9NP61	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9NP61
STRING	9606.ENSP00000263245	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000263245&targetmode=cogs
UCSC	uc003bdd	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003bdd&org=rat
UniGene	Hs.685225	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.685225
UniProtKB	ARFG3_HUMAN	http://www.uniprot.org/uniprot/ARFG3_HUMAN
UniProtKB-AC	Q9NP61	http://www.uniprot.org/uniprot/Q9NP61
charge	swissprot:ARFG3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ARFG3_HUMAN
eggNOG	COG5347	http://eggnogapi.embl.de/nog_data/html/tree/COG5347
eggNOG	KOG0706	http://eggnogapi.embl.de/nog_data/html/tree/KOG0706
epestfind	swissprot:ARFG3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ARFG3_HUMAN
garnier	swissprot:ARFG3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ARFG3_HUMAN
helixturnhelix	swissprot:ARFG3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARFG3_HUMAN
hmoment	swissprot:ARFG3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ARFG3_HUMAN
iep	swissprot:ARFG3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ARFG3_HUMAN
inforesidue	swissprot:ARFG3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ARFG3_HUMAN
neXtProt	NX_Q9NP61	http://www.nextprot.org/db/entry/NX_Q9NP61
octanol	swissprot:ARFG3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ARFG3_HUMAN
pepcoil	swissprot:ARFG3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ARFG3_HUMAN
pepdigest	swissprot:ARFG3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ARFG3_HUMAN
pepinfo	swissprot:ARFG3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ARFG3_HUMAN
pepnet	swissprot:ARFG3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ARFG3_HUMAN
pepstats	swissprot:ARFG3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ARFG3_HUMAN
pepwheel	swissprot:ARFG3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ARFG3_HUMAN
pepwindow	swissprot:ARFG3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ARFG3_HUMAN
sigcleave	swissprot:ARFG3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ARFG3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S45A2_HUMAN	Event=Alternative splicing; Named isoforms=4; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=AIM-1a; IsoId=Q9UMX9-1; Sequence=Displayed; Name=2; Synonyms=AIM-1b; IsoId=Q9UMX9-2; Sequence=VSP_006297, VSP_006298, VSP_006299; Name=3; Synonyms=AIM-1c; IsoId=Q9UMX9-3; Sequence=VSP_006296; Note=No experimental confirmation available.; Name=4; IsoId=Q9UMX9-4; Sequence=VSP_041220, VSP_041221; 
# AltName	S45A2_HUMAN	Melanoma antigen AIM1
# AltName	S45A2_HUMAN	Solute carrier family 45 member 2
# BioGrid	119335	12
# CCDS	CCDS3901	-. [Q9UMX9-1]
# CCDS	CCDS43308	-. [Q9UMX9-4]
# DISEASE	S45A2_HUMAN	Albinism, oculocutaneous, 4 (OCA4) [MIM 606574]  A disorder of pigmentation characterized by reduced biosynthesis of melanin in the skin, hair and eyes. Patients show reduced or lacking pigmentation associated with classic albinism ocular abnormalities, including decreased visual acuity, macular hypoplasia, optic dysplasia, atypical choroidal vessels, and nystagmus. {ECO 0000269|PubMed 11574907, ECO 0000269|PubMed 14722913, ECO 0000269|PubMed 14961451, ECO 0000269|PubMed 15656822, ECO 0000269|PubMed 17768386, ECO 0000269|PubMed 19865097, ECO 0000269|PubMed 23504663, ECO 0000269|PubMed 25703744}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000296589	ENSP00000296589; ENSG00000164175. [Q9UMX9-1]
# Ensembl	ENST00000382102	ENSP00000371534; ENSG00000164175. [Q9UMX9-4]
# ExpressionAtlas	Q9UMX9	baseline and differential
# FUNCTION	S45A2_HUMAN	Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis (By similarity). {ECO 0000250}. 
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0033162	melanosome membrane; IEA:UniProtKB-SubCell.
# GO_function	S45A2_HUMAN	GO 0008506 sucrose proton symporter activity; ISS ParkinsonsUK-UCL.
# GO_process	GO:0007601	visual perception; IEA:UniProtKB-KW.
# GO_process	GO:0015770	sucrose transport; ISS:ParkinsonsUK-UCL.
# GO_process	GO:0042438	melanin biosynthetic process; IEA:UniProtKB-KW.
# GO_process	GO:0048066	developmental pigmentation; IEA:Ensembl.
# GO_process	GO:0050896	response to stimulus; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0019748	secondary metabolic process
# GOslim_process	GO:0043473	pigmentation
# GOslim_process	GO:0050877	neurological system process
# Genevisible	Q9UMX9	HS
# HGNC	HGNC:16472	SLC45A2
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H00168	[Inherited metabolic disease; Skin and connective tissue disease; Eye disease] Oculocutaneous albinism (OCA)
# MIM	227240	phenotype
# MIM	606202	gene
# MIM	606574	phenotype
# Organism	S45A2_HUMAN	Homo sapiens (Human)
# Orphanet	79435	Oculocutaneous albinism type 4
# POLYMORPHISM	S45A2_HUMAN	Genetic variants in SLC45A2 define the skin/hair/eye pigmentation variation locus 5 (SHEP5) [MIM 227240]. Hair, eye and skin pigmentation are among the most visible examples of human phenotypic variation, with a broad normal range that is subject to substantial geographic stratification. In the case of skin, individuals tend to have lighter pigmentation with increasing distance from the equator. By contrast, the majority of variation in human eye and hair color is found among individuals of European ancestry, with most other human populations fixed for brown eyes and black hair. {ECO 0000269|PubMed 18563784, ECO 0000269|PubMed 18683857}. 
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-5662702	Melanin biosynthesis
# RecName	S45A2_HUMAN	Membrane-associated transporter protein
# RefSeq	NP_001012527	NM_001012509.3
# RefSeq	NP_001284346	NM_001297417.2
# RefSeq	NP_057264	NM_016180.4
# SEQUENCE CAUTION	Sequence=AAH03597.1; Type=Frameshift; Positions=188; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S45A2_HUMAN	Melanosome membrane {ECO 0000269|PubMed 17081065}; Multi-pass membrane protein {ECO 0000269|PubMed 17081065}. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.2.4:the glycoside-pentoside-hexuronide (gph)	cation symporter family
# TISSUE SPECIFICITY	S45A2_HUMAN	Expressed in most melanoma cell lines and melanocytes. 
# UCSC	uc003jid	human. [Q9UMX9-1]
# WEB RESOURCE	S45A2_HUMAN	Name=Albinism database (ADB); Note=SLC45A2 mutations; URL="http //albinismdb.med.umn.edu/oca4mut.html";
# WEB RESOURCE	S45A2_HUMAN	Name=Mutations of the MATP gene; Note=Retina International's Scientific Newsletter; URL="http //www.retina-international.org/files/sci-news/matpmut.htm"; 
# eggNOG	ENOG410XPTR	LUCA
# eggNOG	KOG0637	Eukaryota
BLAST	swissprot:S45A2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S45A2_HUMAN
BioCyc	ZFISH:ENSG00000164175-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000164175-MONOMER
COXPRESdb	51151	http://coxpresdb.jp/data/gene/51151.shtml
CleanEx	HS_AIM1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AIM1
CleanEx	HS_SLC45A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC45A2
DOI	10.1002/humu.10311	http://dx.doi.org/10.1002/humu.10311
DOI	10.1002/humu.20143	http://dx.doi.org/10.1002/humu.20143
DOI	10.1002/humu.20804	http://dx.doi.org/10.1002/humu.20804
DOI	10.1002/humu.20823	http://dx.doi.org/10.1002/humu.20823
DOI	10.1002/humu.22315	http://dx.doi.org/10.1002/humu.22315
DOI	10.1007/s00414-004-0490-z	http://dx.doi.org/10.1007/s00414-004-0490-z
DOI	10.1021/pr060363j	http://dx.doi.org/10.1021/pr060363j
DOI	10.1038/jid.2009.339	http://dx.doi.org/10.1038/jid.2009.339
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1086/324340	http://dx.doi.org/10.1086/324340
DOI	10.1086/382195	http://dx.doi.org/10.1086/382195
DOI	10.1086/522235	http://dx.doi.org/10.1086/522235
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/ced.12612	http://dx.doi.org/10.1111/ced.12612
DOI	10.1111/j.1365-2133.2005.06403.x	http://dx.doi.org/10.1111/j.1365-2133.2005.06403.x
DOI	10.1111/j.1469-1809.2006.00261.x	http://dx.doi.org/10.1111/j.1469-1809.2006.00261.x
EMBL	AC139777	http://www.ebi.ac.uk/ena/data/view/AC139777
EMBL	AC139783	http://www.ebi.ac.uk/ena/data/view/AC139783
EMBL	AF172849	http://www.ebi.ac.uk/ena/data/view/AF172849
EMBL	BC003597	http://www.ebi.ac.uk/ena/data/view/BC003597
EMBL	BC064405	http://www.ebi.ac.uk/ena/data/view/BC064405
Ensembl	ENST00000296589	http://www.ensembl.org/id/ENST00000296589
Ensembl	ENST00000382102	http://www.ensembl.org/id/ENST00000382102
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0033162	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033162
GO_function	GO:0008506	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008506
GO_process	GO:0007601	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007601
GO_process	GO:0015770	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015770
GO_process	GO:0042438	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042438
GO_process	GO:0048066	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048066
GO_process	GO:0050896	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050896
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0019748	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019748
GOslim_process	GO:0043473	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043473
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	SLC45A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC45A2
GeneID	51151	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51151
GeneTree	ENSGT00390000018882	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000018882
HGNC	HGNC:16472	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16472
HOGENOM	HOG000128553	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000128553&db=HOGENOM6
HOVERGEN	HBG018570	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG018570&db=HOVERGEN
InParanoid	Q9UMX9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UMX9
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	51151	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=51151
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00168	http://www.genome.jp/dbget-bin/www_bget?H00168
KEGG_Gene	hsa:51151	http://www.genome.jp/dbget-bin/www_bget?hsa:51151
KEGG_Orthology	KO:K15378	http://www.genome.jp/dbget-bin/www_bget?KO:K15378
MIM	227240	http://www.ncbi.nlm.nih.gov/omim/227240
MIM	606202	http://www.ncbi.nlm.nih.gov/omim/606202
MIM	606574	http://www.ncbi.nlm.nih.gov/omim/606574
OMA	TSFGVMS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TSFGVMS
Orphanet	79435	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=79435
OrthoDB	EOG091G05H5	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05H5
PSORT	swissprot:S45A2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S45A2_HUMAN
PSORT-B	swissprot:S45A2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S45A2_HUMAN
PSORT2	swissprot:S45A2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S45A2_HUMAN
PharmGKB	PA134897756	http://www.pharmgkb.org/do/serve?objId=PA134897756&objCls=Gene
Phobius	swissprot:S45A2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S45A2_HUMAN
PhylomeDB	Q9UMX9	http://phylomedb.org/?seqid=Q9UMX9
ProteinModelPortal	Q9UMX9	http://www.proteinmodelportal.org/query/uniprot/Q9UMX9
PubMed	11221837	http://www.ncbi.nlm.nih.gov/pubmed/11221837
PubMed	11574907	http://www.ncbi.nlm.nih.gov/pubmed/11574907
PubMed	14722913	http://www.ncbi.nlm.nih.gov/pubmed/14722913
PubMed	14961451	http://www.ncbi.nlm.nih.gov/pubmed/14961451
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	15455243	http://www.ncbi.nlm.nih.gov/pubmed/15455243
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15656822	http://www.ncbi.nlm.nih.gov/pubmed/15656822
PubMed	15714523	http://www.ncbi.nlm.nih.gov/pubmed/15714523
PubMed	17044855	http://www.ncbi.nlm.nih.gov/pubmed/17044855
PubMed	17081065	http://www.ncbi.nlm.nih.gov/pubmed/17081065
PubMed	17768386	http://www.ncbi.nlm.nih.gov/pubmed/17768386
PubMed	17999355	http://www.ncbi.nlm.nih.gov/pubmed/17999355
PubMed	18563784	http://www.ncbi.nlm.nih.gov/pubmed/18563784
PubMed	18683857	http://www.ncbi.nlm.nih.gov/pubmed/18683857
PubMed	19865097	http://www.ncbi.nlm.nih.gov/pubmed/19865097
PubMed	23504663	http://www.ncbi.nlm.nih.gov/pubmed/23504663
PubMed	25703744	http://www.ncbi.nlm.nih.gov/pubmed/25703744
Reactome	R-HSA-5662702	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5662702
RefSeq	NP_001012527	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001012527
RefSeq	NP_001284346	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001284346
RefSeq	NP_057264	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_057264
STRING	9606.ENSP00000296589	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000296589&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.2.4	http://www.tcdb.org/search/result.php?tc=2.A.2.4
UCSC	uc003jid	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003jid&org=rat
UniGene	Hs.278962	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.278962
UniProtKB	S45A2_HUMAN	http://www.uniprot.org/uniprot/S45A2_HUMAN
UniProtKB-AC	Q9UMX9	http://www.uniprot.org/uniprot/Q9UMX9
charge	swissprot:S45A2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S45A2_HUMAN
eggNOG	ENOG410XPTR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPTR
eggNOG	KOG0637	http://eggnogapi.embl.de/nog_data/html/tree/KOG0637
epestfind	swissprot:S45A2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S45A2_HUMAN
garnier	swissprot:S45A2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S45A2_HUMAN
helixturnhelix	swissprot:S45A2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S45A2_HUMAN
hmoment	swissprot:S45A2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S45A2_HUMAN
iep	swissprot:S45A2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S45A2_HUMAN
inforesidue	swissprot:S45A2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S45A2_HUMAN
neXtProt	NX_Q9UMX9	http://www.nextprot.org/db/entry/NX_Q9UMX9
octanol	swissprot:S45A2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S45A2_HUMAN
pepcoil	swissprot:S45A2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S45A2_HUMAN
pepdigest	swissprot:S45A2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S45A2_HUMAN
pepinfo	swissprot:S45A2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S45A2_HUMAN
pepnet	swissprot:S45A2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S45A2_HUMAN
pepstats	swissprot:S45A2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S45A2_HUMAN
pepwheel	swissprot:S45A2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S45A2_HUMAN
pepwindow	swissprot:S45A2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S45A2_HUMAN
sigcleave	swissprot:S45A2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S45A2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TRPM6_HUMAN	Event=Alternative splicing; Named isoforms=7; Name=TRPM6a; IsoId=Q9BX84-1; Sequence=Displayed; Name=TRPM6b; IsoId=Q9BX84-2; Sequence=VSP_012069; Name=TRPM6c; IsoId=Q9BX84-3; Sequence=VSP_012070; Name=TRPM6t; IsoId=Q9BX84-4; Sequence=VSP_012075, VSP_012076; Name=M6-kinase 1; IsoId=Q9BX84-5; Sequence=VSP_012074; Note=Lacks the ion channel region.; Name=M6-kinase 2; IsoId=Q9BX84-6; Sequence=VSP_012073; Note=Lacks the ion channel region.; Name=M6-kinase 3; IsoId=Q9BX84-7; Sequence=VSP_012071, VSP_012072; Note=Lacks the ion channel region.; 
# AltName	TRPM6_HUMAN	Channel kinase 2
# AltName	TRPM6_HUMAN	Melastatin-related TRP cation channel 6
# CATALYTIC ACTIVITY	TRPM6_HUMAN	ATP + a protein = ADP + a phosphoprotein. 
# CCDS	CCDS55318	-. [Q9BX84-3]
# CCDS	CCDS55319	-. [Q9BX84-2]
# CCDS	CCDS6647	-. [Q9BX84-1]
# DISEASE	TRPM6_HUMAN	Hypomagnesemia 1 (HOMG1) [MIM 602014]  A disorder due to a primary defect in intestinal magnesium absorption. It is characterized by low levels of serum magnesium alongside with a normal renal magnesium secretion, secondary hypocalcemia and calcinocis. Affected individuals show neurologic symptoms of hypomagnesemic hypocalcemia, including seizures and muscle spasms, during infancy. Hypocalcemia is secondary to parathyroid failure resulting from magnesium deficiency. Untreated, the disorder may be fatal or may result in neurological damage. {ECO 0000269|PubMed 12032568, ECO 0000269|PubMed 23942199}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000360774	ENSP00000354006; ENSG00000119121. [Q9BX84-1]
# Ensembl	ENST00000361255	ENSP00000354962; ENSG00000119121. [Q9BX84-3]
# Ensembl	ENST00000449912	ENSP00000396672; ENSG00000119121. [Q9BX84-2]
# ExpressionAtlas	Q9BX84	baseline and differential
# FUNCTION	TRPM6_HUMAN	Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0016324	apical plasma membrane; IEA:Ensembl.
# GO_component	GO:0031526	brush border membrane; IEA:Ensembl.
# GO_function	GO:0004674	protein serine/threonine kinase activity; IEA:UniProtKB-KW.
# GO_function	GO:0005262	calcium channel activity; TAS:Reactome.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0009636	response to toxic substance; IDA:UniProtKB.
# GO_process	GO:0051262	protein tetramerization; IEA:InterPro.
# GO_process	GO:0070588	calcium ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0016301	kinase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9BX84	HS
# HGNC	HGNC:17995	TRPM6
# IntAct	Q9BX84	3
# InterPro	IPR004166	MHCK_EF2_kinase
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR011009	Kinase-like_dom
# InterPro	IPR029597	TRPM6
# InterPro	IPR032415	TRPM_tetra
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Brite	ko01001	 Protein kinases
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H01210	[Inherited metabolic disease] Hypomagnesemia
# KEGG_Pathway	ko04978	Mineral absorption
# MIM	602014	phenotype
# MIM	607009	gene
# Organism	TRPM6_HUMAN	Homo sapiens (Human)
# Orphanet	30924	Primary hypomagnesemia with secondary hypocalcemia
# PANTHER	PTHR13800:SF15	PTHR13800:SF15; 2
# PROSITE	PS51158	ALPHA_KINASE
# Pfam	PF00520	Ion_trans
# Pfam	PF02816	Alpha_kinase
# Pfam	PF16519	TRPM_tetra
# Proteomes	UP000005640	Chromosome 9
# Reactome	R-HSA-3295583	TRP channels
# RecName	TRPM6_HUMAN	Transient receptor potential cation channel subfamily M member 6
# RefSeq	NP_001170781	NM_001177310.1. [Q9BX84-2]
# RefSeq	NP_001170782	NM_001177311.1. [Q9BX84-3]
# RefSeq	NP_060132	NM_017662.4. [Q9BX84-1]
# SIMILARITY	Contains 1 alpha-type protein kinase domain. {ECO:0000255|PROSITE-ProRule	PRU00501}.
# SIMILARITY	In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. {ECO	0000305}. 
# SIMILARITY	In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM6 sub-subfamily. {ECO	0000305}. 
# SMART	SM00811	Alpha_kinase
# SUBCELLULAR LOCATION	TRPM6_HUMAN	Cell membrane {ECO 0000269|PubMed 23942199}; Multi-pass membrane protein. 
# SUBUNIT	TRPM6_HUMAN	Forms heterodimers with TRPM7. TRPM6 requires the presence of TRPM7 to be targeted to the cell membrane (in HEK 293 cells). Interacts (via kinase domain) with RACK1. {ECO 0000269|PubMed 14976260, ECO 0000269|PubMed 18258429}. 
# SUPFAM	SSF56112	SSF56112
# TCDB	1.A.4.5	the transient receptor potential ca(2+) channel (trp-cc) family
# TISSUE SPECIFICITY	TRPM6_HUMAN	Highly expressed in kidney and colon. Isoform TRPM6a and isoform TRPM6b, are coexpressed with TRPM7 in kidney, and testis, and are also found in several cell lines of lung origin. Isoform TRPM6c is detected only in testis and in NCI-H510A small cell lung carcinoma cells. 
# UCSC	uc004ajk	human. [Q9BX84-1]
# eggNOG	ENOG410INBW	Eukaryota
# eggNOG	ENOG410ZSH9	LUCA
BLAST	swissprot:TRPM6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TRPM6_HUMAN
BioCyc	ZFISH:HS04275-MONOMER	http://biocyc.org/getid?id=ZFISH:HS04275-MONOMER
COXPRESdb	140803	http://coxpresdb.jp/data/gene/140803.shtml
CleanEx	HS_TRPM6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TRPM6
DOI	10.1016/j.cub.2007.12.058	http://dx.doi.org/10.1016/j.cub.2007.12.058
DOI	10.1038/ejhg.2013.178	http://dx.doi.org/10.1038/ejhg.2013.178
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
DOI	10.1038/nature05610	http://dx.doi.org/10.1038/nature05610
DOI	10.1038/ng889	http://dx.doi.org/10.1038/ng889
DOI	10.1073/pnas.0305252101	http://dx.doi.org/10.1073/pnas.0305252101
EC_number	EC:2.7.11.1	http://www.genome.jp/dbget-bin/www_bget?EC:2.7.11.1
EMBL	AF350881	http://www.ebi.ac.uk/ena/data/view/AF350881
EMBL	AF448232	http://www.ebi.ac.uk/ena/data/view/AF448232
EMBL	AL354795	http://www.ebi.ac.uk/ena/data/view/AL354795
EMBL	AY333282	http://www.ebi.ac.uk/ena/data/view/AY333282
EMBL	AY333283	http://www.ebi.ac.uk/ena/data/view/AY333283
EMBL	AY333284	http://www.ebi.ac.uk/ena/data/view/AY333284
EMBL	AY333285	http://www.ebi.ac.uk/ena/data/view/AY333285
EMBL	AY333286	http://www.ebi.ac.uk/ena/data/view/AY333286
EMBL	AY333287	http://www.ebi.ac.uk/ena/data/view/AY333287
EMBL	AY333288	http://www.ebi.ac.uk/ena/data/view/AY333288
ENZYME	2.7.11.1	http://enzyme.expasy.org/EC/2.7.11.1
Ensembl	ENST00000360774	http://www.ensembl.org/id/ENST00000360774
Ensembl	ENST00000361255	http://www.ensembl.org/id/ENST00000361255
Ensembl	ENST00000449912	http://www.ensembl.org/id/ENST00000449912
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0031526	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031526
GO_function	GO:0004674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004674
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0009636	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009636
GO_process	GO:0051262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051262
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0016301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	TRPM6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TRPM6
GeneID	140803	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=140803
GeneTree	ENSGT00760000119127	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119127
H-InvDB	HIX0008102	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0008102
HGNC	HGNC:17995	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17995
HOGENOM	HOG000230920	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230920&db=HOGENOM6
HOVERGEN	HBG055663	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG055663&db=HOVERGEN
HPA	HPA007037	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA007037
InParanoid	Q9BX84	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9BX84
IntAct	Q9BX84	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9BX84*
IntEnz	2.7.11.1	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.11.1
InterPro	IPR004166	http://www.ebi.ac.uk/interpro/entry/IPR004166
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR011009	http://www.ebi.ac.uk/interpro/entry/IPR011009
InterPro	IPR029597	http://www.ebi.ac.uk/interpro/entry/IPR029597
InterPro	IPR032415	http://www.ebi.ac.uk/interpro/entry/IPR032415
Jabion	140803	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=140803
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Brite	ko01001	http://www.genome.jp/dbget-bin/www_bget?ko01001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H01210	http://www.genome.jp/dbget-bin/www_bget?H01210
KEGG_Gene	hsa:140803	http://www.genome.jp/dbget-bin/www_bget?hsa:140803
KEGG_Orthology	KO:K04981	http://www.genome.jp/dbget-bin/www_bget?KO:K04981
KEGG_Pathway	ko04978	http://www.genome.jp/kegg-bin/show_pathway?ko04978
MIM	602014	http://www.ncbi.nlm.nih.gov/omim/602014
MIM	607009	http://www.ncbi.nlm.nih.gov/omim/607009
MINT	MINT-6699468	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6699468
OMA	LMECMVH	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LMECMVH
Orphanet	30924	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=30924
OrthoDB	EOG091G0DHL	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0DHL
PANTHER	PTHR13800:SF15	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13800:SF15
PROSITE	PS51158	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51158
PSORT	swissprot:TRPM6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TRPM6_HUMAN
PSORT-B	swissprot:TRPM6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TRPM6_HUMAN
PSORT2	swissprot:TRPM6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TRPM6_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF02816	http://pfam.xfam.org/family/PF02816
Pfam	PF16519	http://pfam.xfam.org/family/PF16519
PharmGKB	PA38479	http://www.pharmgkb.org/do/serve?objId=PA38479&objCls=Gene
Phobius	swissprot:TRPM6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TRPM6_HUMAN
PhylomeDB	Q9BX84	http://phylomedb.org/?seqid=Q9BX84
ProteinModelPortal	Q9BX84	http://www.proteinmodelportal.org/query/uniprot/Q9BX84
PubMed	11357414	http://www.ncbi.nlm.nih.gov/pubmed/11357414
PubMed	12032568	http://www.ncbi.nlm.nih.gov/pubmed/12032568
PubMed	14976260	http://www.ncbi.nlm.nih.gov/pubmed/14976260
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
PubMed	17344846	http://www.ncbi.nlm.nih.gov/pubmed/17344846
PubMed	18258429	http://www.ncbi.nlm.nih.gov/pubmed/18258429
PubMed	23942199	http://www.ncbi.nlm.nih.gov/pubmed/23942199
Reactome	R-HSA-3295583	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3295583
RefSeq	NP_001170781	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001170781
RefSeq	NP_001170782	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001170782
RefSeq	NP_060132	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060132
SMART	SM00811	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00811
SMR	Q9BX84	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9BX84
STRING	9606.ENSP00000354006	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000354006&targetmode=cogs
SUPFAM	SSF56112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56112
TCDB	1.A.4.5	http://www.tcdb.org/search/result.php?tc=1.A.4.5
UCSC	uc004ajk	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004ajk&org=rat
UniGene	Hs.272225	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.272225
UniProtKB	TRPM6_HUMAN	http://www.uniprot.org/uniprot/TRPM6_HUMAN
UniProtKB-AC	Q9BX84	http://www.uniprot.org/uniprot/Q9BX84
charge	swissprot:TRPM6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TRPM6_HUMAN
eggNOG	ENOG410INBW	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410INBW
eggNOG	ENOG410ZSH9	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZSH9
epestfind	swissprot:TRPM6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TRPM6_HUMAN
garnier	swissprot:TRPM6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TRPM6_HUMAN
helixturnhelix	swissprot:TRPM6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRPM6_HUMAN
hmoment	swissprot:TRPM6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TRPM6_HUMAN
iep	swissprot:TRPM6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TRPM6_HUMAN
inforesidue	swissprot:TRPM6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TRPM6_HUMAN
neXtProt	NX_Q9BX84	http://www.nextprot.org/db/entry/NX_Q9BX84
octanol	swissprot:TRPM6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TRPM6_HUMAN
pepcoil	swissprot:TRPM6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TRPM6_HUMAN
pepdigest	swissprot:TRPM6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TRPM6_HUMAN
pepinfo	swissprot:TRPM6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TRPM6_HUMAN
pepnet	swissprot:TRPM6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TRPM6_HUMAN
pepstats	swissprot:TRPM6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TRPM6_HUMAN
pepwheel	swissprot:TRPM6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TRPM6_HUMAN
pepwindow	swissprot:TRPM6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TRPM6_HUMAN
sigcleave	swissprot:TRPM6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TRPM6_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AQP4_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=2; IsoId=P55087-1; Sequence=Displayed; Name=1; IsoId=P55087-2; Sequence=VSP_003232; 
# AltName	AQP4_HUMAN	Mercurial-insensitive water channel
# AltName	AQP4_HUMAN	WCH4
# BioGrid	106857	2
# CCDS	CCDS11889	-. [P55087-1]
# CCDS	CCDS58617	-. [P55087-2]
# CDD	cd00333	MIP
# ChiTaRS	AQP4	human
# DOMAIN	AQP4_HUMAN	Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). 
# Ensembl	ENST00000383168	ENSP00000372654; ENSG00000171885. [P55087-1]
# Ensembl	ENST00000440832	ENSP00000393121; ENSG00000171885. [P55087-2]
# Ensembl	ENST00000581374	ENSP00000462597; ENSG00000171885. [P55087-2]
# ExpressionAtlas	P55087	baseline and differential
# FUNCTION	AQP4_HUMAN	Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system. 
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0009897	external side of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016323	basolateral plasma membrane; IBA:GO_Central.
# GO_function	GO:0005372	water transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0015250	water channel activity; EXP:Reactome.
# GO_function	GO:0015254	glycerol channel activity; IBA:GO_Central.
# GO_process	GO:0003091	renal water homeostasis; TAS:Reactome.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006833	water transport; TAS:Reactome.
# GO_process	GO:0009992	cellular water homeostasis; IBA:GO_Central.
# GO_process	GO:0034220	ion transmembrane transport; IBA:GO_Central.
# GO_process	GO:0050891	multicellular organismal water homeostasis; IEP:UniProtKB.
# GO_process	GO:0071346	cellular response to interferon-gamma; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.1080.10	-; 1.
# Genevisible	P55087	HS
# HGNC	HGNC:637	AQP4
# InterPro	IPR000425	MIP
# InterPro	IPR022357	MIP_CS
# InterPro	IPR023271	Aquaporin-like
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H01491	[Nervous system disease; Immune system disease] Devic disease
# KEGG_Pathway	ko04962	Vasopressin-regulated water reabsorption
# KEGG_Pathway	ko04976	Bile secretion
# MIM	600308	gene
# Organism	AQP4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR19139	PTHR19139
# PDB	3GD8	X-ray; 1.80 A; A=32-254
# PIR	I39178	I39178
# PRINTS	PR00783	MINTRINSICP
# PROSITE	PS00221	MIP
# PTM	AQP4_HUMAN	Phosphorylation by PKC at Ser-180 reduces conductance by 50%. Phosphorylation by PKG at Ser-111 in response to glutamats increases conductance by 40% (By similarity). {ECO 0000250}. 
# Pfam	PF00230	MIP
# Proteomes	UP000005640	Chromosome 18
# Reactome	R-HSA-432040	Vasopressin regulates renal water homeostasis via Aquaporins
# Reactome	R-HSA-432047	Passive transport by Aquaporins
# RecName	AQP4_HUMAN	Aquaporin-4
# RefSeq	NP_001641	NM_001650.5. [P55087-1]
# RefSeq	NP_004019	NM_004028.4. [P55087-2]
# SEQUENCE CAUTION	Sequence=AAC50284.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAC52112.1; Type=Erroneous initiation; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the MIP/aquaporin (TC 1.A.8) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	AQP4_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	AQP4_HUMAN	Homotetramer. Part of a complex containing MLC1, TRPV4, HEPACAM and ATP1B1. {ECO 0000269|PubMed 19383790, ECO 0000269|PubMed 22328087}. 
# SUPFAM	SSF81338	SSF81338
# TCDB	1.A.8.8	the major intrinsic protein (mip) family
# TIGRFAMs	TIGR00861	MIP
# TISSUE SPECIFICITY	AQP4_HUMAN	Brain - muscle >> heart, kidney, lung, and trachea. 
# UCSC	uc002kvz	human. [P55087-1]
# WEB RESOURCE	AQP4_HUMAN	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/AQP4ID684ch18q11.html";
# eggNOG	COG0580	LUCA
# eggNOG	KOG0223	Eukaryota
BLAST	swissprot:AQP4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AQP4_HUMAN
BioCyc	ZFISH:ENSG00000171885-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000171885-MONOMER
COXPRESdb	361	http://coxpresdb.jp/data/gene/361.shtml
CleanEx	HS_AQP4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AQP4
DIP	DIP-48842N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48842N
DOI	10.1016/0014-5793(96)00092-0	http://dx.doi.org/10.1016/0014-5793(96)00092-0
DOI	10.1038/nature03983	http://dx.doi.org/10.1038/nature03983
DOI	10.1073/pnas.0902725106	http://dx.doi.org/10.1073/pnas.0902725106
DOI	10.1073/pnas.93.20.10908	http://dx.doi.org/10.1073/pnas.93.20.10908
DOI	10.1074/jbc.270.39.22907	http://dx.doi.org/10.1074/jbc.270.39.22907
DOI	10.1093/hmg/dds032	http://dx.doi.org/10.1093/hmg/dds032
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC018371	http://www.ebi.ac.uk/ena/data/view/AC018371
EMBL	BC022286	http://www.ebi.ac.uk/ena/data/view/BC022286
EMBL	D63412	http://www.ebi.ac.uk/ena/data/view/D63412
EMBL	U34845	http://www.ebi.ac.uk/ena/data/view/U34845
EMBL	U34846	http://www.ebi.ac.uk/ena/data/view/U34846
EMBL	U63622	http://www.ebi.ac.uk/ena/data/view/U63622
EMBL	U63623	http://www.ebi.ac.uk/ena/data/view/U63623
Ensembl	ENST00000383168	http://www.ensembl.org/id/ENST00000383168
Ensembl	ENST00000440832	http://www.ensembl.org/id/ENST00000440832
Ensembl	ENST00000581374	http://www.ensembl.org/id/ENST00000581374
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0009897	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009897
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_function	GO:0005372	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005372
GO_function	GO:0015250	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015250
GO_function	GO:0015254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015254
GO_process	GO:0003091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003091
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006833	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006833
GO_process	GO:0009992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009992
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0050891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050891
GO_process	GO:0071346	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071346
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.1080.10	http://www.cathdb.info/version/latest/superfamily/1.20.1080.10
GeneCards	AQP4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=AQP4
GeneID	361	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=361
GeneTree	ENSGT00760000119223	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119223
HGNC	HGNC:637	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:637
HOGENOM	HOG000288286	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000288286&db=HOGENOM6
HOVERGEN	HBG000312	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG000312&db=HOVERGEN
HPA	CAB005079	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB005079
HPA	CAB058689	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB058689
HPA	HPA014784	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014784
InParanoid	P55087	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P55087
InterPro	IPR000425	http://www.ebi.ac.uk/interpro/entry/IPR000425
InterPro	IPR022357	http://www.ebi.ac.uk/interpro/entry/IPR022357
InterPro	IPR023271	http://www.ebi.ac.uk/interpro/entry/IPR023271
Jabion	361	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=361
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H01491	http://www.genome.jp/dbget-bin/www_bget?H01491
KEGG_Gene	hsa:361	http://www.genome.jp/dbget-bin/www_bget?hsa:361
KEGG_Orthology	KO:K09866	http://www.genome.jp/dbget-bin/www_bget?KO:K09866
KEGG_Pathway	ko04962	http://www.genome.jp/kegg-bin/show_pathway?ko04962
KEGG_Pathway	ko04976	http://www.genome.jp/kegg-bin/show_pathway?ko04976
MIM	600308	http://www.ncbi.nlm.nih.gov/omim/600308
OMA	CRRESIM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CRRESIM
OrthoDB	EOG091G166T	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G166T
PANTHER	PTHR19139	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19139
PDB	3GD8	http://www.ebi.ac.uk/pdbe-srv/view/entry/3GD8
PDBsum	3GD8	http://www.ebi.ac.uk/pdbsum/3GD8
PRINTS	PR00783	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00783
PROSITE	PS00221	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00221
PSORT	swissprot:AQP4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AQP4_HUMAN
PSORT-B	swissprot:AQP4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AQP4_HUMAN
PSORT2	swissprot:AQP4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AQP4_HUMAN
Pfam	PF00230	http://pfam.xfam.org/family/PF00230
PharmGKB	PA24922	http://www.pharmgkb.org/do/serve?objId=PA24922&objCls=Gene
Phobius	swissprot:AQP4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AQP4_HUMAN
PhylomeDB	P55087	http://phylomedb.org/?seqid=P55087
ProteinModelPortal	P55087	http://www.proteinmodelportal.org/query/uniprot/P55087
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16177791	http://www.ncbi.nlm.nih.gov/pubmed/16177791
PubMed	19383790	http://www.ncbi.nlm.nih.gov/pubmed/19383790
PubMed	22328087	http://www.ncbi.nlm.nih.gov/pubmed/22328087
PubMed	7559426	http://www.ncbi.nlm.nih.gov/pubmed/7559426
PubMed	8601457	http://www.ncbi.nlm.nih.gov/pubmed/8601457
PubMed	8855281	http://www.ncbi.nlm.nih.gov/pubmed/8855281
Reactome	R-HSA-432040	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432040
Reactome	R-HSA-432047	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-432047
RefSeq	NP_001641	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001641
RefSeq	NP_004019	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004019
SMR	P55087	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P55087
STRING	9606.ENSP00000372654	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000372654&targetmode=cogs
SUPFAM	SSF81338	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81338
TCDB	1.A.8.8	http://www.tcdb.org/search/result.php?tc=1.A.8.8
TIGRFAMs	TIGR00861	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00861
UCSC	uc002kvz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002kvz&org=rat
UniGene	Hs.315369	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.315369
UniProtKB	AQP4_HUMAN	http://www.uniprot.org/uniprot/AQP4_HUMAN
UniProtKB-AC	P55087	http://www.uniprot.org/uniprot/P55087
charge	swissprot:AQP4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AQP4_HUMAN
eggNOG	COG0580	http://eggnogapi.embl.de/nog_data/html/tree/COG0580
eggNOG	KOG0223	http://eggnogapi.embl.de/nog_data/html/tree/KOG0223
epestfind	swissprot:AQP4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AQP4_HUMAN
garnier	swissprot:AQP4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AQP4_HUMAN
helixturnhelix	swissprot:AQP4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AQP4_HUMAN
hmoment	swissprot:AQP4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AQP4_HUMAN
iep	swissprot:AQP4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AQP4_HUMAN
inforesidue	swissprot:AQP4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AQP4_HUMAN
neXtProt	NX_P55087	http://www.nextprot.org/db/entry/NX_P55087
octanol	swissprot:AQP4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AQP4_HUMAN
pepcoil	swissprot:AQP4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AQP4_HUMAN
pepdigest	swissprot:AQP4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AQP4_HUMAN
pepinfo	swissprot:AQP4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AQP4_HUMAN
pepnet	swissprot:AQP4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AQP4_HUMAN
pepstats	swissprot:AQP4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AQP4_HUMAN
pepwheel	swissprot:AQP4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AQP4_HUMAN
pepwindow	swissprot:AQP4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AQP4_HUMAN
sigcleave	swissprot:AQP4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AQP4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S47A1_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q96FL8-1; Sequence=Displayed; Name=2; IsoId=Q96FL8-2; Sequence=VSP_029903, VSP_029904; Note=No experimental confirmation available.; Name=3; IsoId=Q96FL8-3; Sequence=VSP_029905; Note=No experimental confirmation available.; 
# AltName	S47A1_HUMAN	Solute carrier family 47 member 1
# BIOPHYSICOCHEMICAL PROPERTIES	S47A1_HUMAN	Kinetic parameters  KM=0.38 mM for TEA {ECO 0000269|PubMed 16330770, ECO 0000269|PubMed 17509534}; KM=0.10 mM for MPP {ECO 0000269|PubMed 16330770, ECO 0000269|PubMed 17509534}; KM=0.17 mM for cimetidine {ECO 0000269|PubMed 16330770, ECO 0000269|PubMed 17509534}; KM=0.78 mM for metformin {ECO 0000269|PubMed 16330770, ECO 0000269|PubMed 17509534}; KM=2.1 mM for guanidine {ECO 0000269|PubMed 16330770, ECO 0000269|PubMed 17509534}; KM=1.23 mM for procainamide {ECO 0000269|PubMed 16330770, ECO 0000269|PubMed 17509534}; KM=0.07 mM for topotecan {ECO 0000269|PubMed 16330770, ECO 0000269|PubMed 17509534}; KM=0.47 mM for estrone sulfate {ECO 0000269|PubMed 16330770, ECO 0000269|PubMed 17509534}; KM=2.64 mM for acyclovir {ECO 0000269|PubMed 16330770, ECO 0000269|PubMed 17509534}; KM=5.12 mM for ganciclovir {ECO 0000269|PubMed 16330770, ECO 0000269|PubMed 17509534}; Vmax=1.185 nmol/min/mg enzyme toward TEA {ECO 0000269|PubMed 16330770, ECO 0000269|PubMed 17509534}; Vmax=0.735 nmol/min/mg enzyme toward MPP {ECO 0000269|PubMed 16330770, ECO 0000269|PubMed 17509534}; Vmax=0.135 nmol/min/mg enzyme toward cimetidine {ECO 0000269|PubMed 16330770, ECO 0000269|PubMed 17509534}; Vmax=2.23 nmol/min/mg enzyme toward metformin {ECO 0000269|PubMed 16330770, ECO 0000269|PubMed 17509534}; Vmax=0.89 nmol/min/mg enzyme toward guanidine {ECO 0000269|PubMed 16330770, ECO 0000269|PubMed 17509534}; Vmax=3.78 nmol/min/mg enzyme toward procainamide {ECO 0000269|PubMed 16330770, ECO 0000269|PubMed 17509534}; Vmax=0.21 nmol/min/mg enzyme toward topotecan {ECO 0000269|PubMed 16330770, ECO 0000269|PubMed 17509534}; Vmax=0.265 nmol/min/mg enzyme toward estrone sulfate {ECO 0000269|PubMed 16330770, ECO 0000269|PubMed 17509534}; Vmax=0.62 nmol/min/mg enzyme toward acyclovir {ECO 0000269|PubMed 16330770, ECO 0000269|PubMed 17509534}; Vmax=1.08 nmol/min/mg enzyme toward ganciclovir {ECO 0000269|PubMed 16330770, ECO 0000269|PubMed 17509534}; pH dependence  Optimum pH is 8.5. Active from pH 6 to 8.5. {ECO 0000269|PubMed 16330770, ECO 0000269|PubMed 17509534}; 
# BioGrid	120535	27
# CCDS	CCDS11209	-. [Q96FL8-1]
# ChiTaRS	SLC47A1	human
# DrugBank	DB00199	Erythromycin
# DrugBank	DB00331	Metformin
# DrugBank	DB00501	Cimetidine
# DrugBank	DB00567	Cephalexin
# DrugBank	DB00787	Aciclovir
# DrugBank	DB00877	Sirolimus
# DrugBank	DB01237	Bromodiphenhydramine
# Ensembl	ENST00000270570	ENSP00000270570; ENSG00000142494. [Q96FL8-1]
# Ensembl	ENST00000395585	ENSP00000378951; ENSG00000142494. [Q96FL8-3]
# ExpressionAtlas	Q96FL8	baseline and differential
# FUNCTION	S47A1_HUMAN	Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes. {ECO 0000269|PubMed 16330770, ECO 0000269|PubMed 16996621, ECO 0000269|PubMed 17495125, ECO 0000269|PubMed 17509534, ECO 0000269|PubMed 17582384}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0031988	membrane-bounded vesicle; IBA:GO_Central.
# GO_function	GO:0015238	drug transmembrane transporter activity; IBA:GO_Central.
# GO_function	S47A1_HUMAN	GO 0005451 monovalent cation proton antiporter activity; IBA GO_Central.
# GO_function	S47A1_HUMAN	GO 0015307 drug proton antiporter activity; TAS Reactome.
# GO_process	GO:0006855	drug transmembrane transport; IBA:GO_Central.
# GO_process	GO:0015695	organic cation transport; IBA:GO_Central.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q96FL8	HS
# HGNC	HGNC:25588	SLC47A1
# InterPro	IPR002528	MATE_fam
# KEGG_Brite	ko02001	Solute carrier family
# MIM	609832	gene
# Organism	S47A1_HUMAN	Homo sapiens (Human)
# Pfam	PF01554	MatE; 2
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-425366	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
# RecName	S47A1_HUMAN	Multidrug and toxin extrusion protein 1
# RefSeq	NP_060712	NM_018242.2. [Q96FL8-1]
# SEQUENCE CAUTION	Sequence=AAH50592.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S47A1_HUMAN	Cell membrane {ECO 0000269|PubMed 16330770, ECO 0000269|PubMed 16641166}; Multi-pass membrane protein {ECO 0000269|PubMed 16330770, ECO 0000269|PubMed 16641166}. Note=Predominantly localized at the plasma membrane but also found in intracellular organelles. 
# TCDB	2.A.66.1.14	the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily
# TIGRFAMs	TIGR00797	matE
# TISSUE SPECIFICITY	S47A1_HUMAN	Expressed in adrenal gland, and to a lower extent in liver, skeletal muscle and kidney (especially found in luminal membranes of the urinary tubules, bile caniculi and brush border membranes). {ECO 0000269|PubMed 16330770, ECO 0000269|PubMed 17509534}. 
# UCSC	uc002gvx	human. [Q96FL8-1]
# eggNOG	COG0534	LUCA
# eggNOG	KOG1347	Eukaryota
BLAST	swissprot:S47A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S47A1_HUMAN
BioCyc	ZFISH:ENSG00000142494-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000142494-MONOMER
COG	COG0534	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0534
COXPRESdb	55244	http://coxpresdb.jp/data/gene/55244.shtml
CleanEx	HS_SLC47A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC47A1
DOI	10.1016/j.bcp.2007.03.004	http://dx.doi.org/10.1016/j.bcp.2007.03.004
DOI	10.1016/j.bcp.2007.04.010	http://dx.doi.org/10.1016/j.bcp.2007.04.010
DOI	10.1016/j.tips.2006.09.001	http://dx.doi.org/10.1016/j.tips.2006.09.001
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0506483102	http://dx.doi.org/10.1073/pnas.0506483102
DOI	10.1073/pnas.1210303109	http://dx.doi.org/10.1073/pnas.1210303109
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1124/jpet.107.123554	http://dx.doi.org/10.1124/jpet.107.123554
DOI	10.1152/ajpcell.00090.2006	http://dx.doi.org/10.1152/ajpcell.00090.2006
DrugBank	DB00199	http://www.drugbank.ca/drugs/DB00199
DrugBank	DB00331	http://www.drugbank.ca/drugs/DB00331
DrugBank	DB00501	http://www.drugbank.ca/drugs/DB00501
DrugBank	DB00567	http://www.drugbank.ca/drugs/DB00567
DrugBank	DB00787	http://www.drugbank.ca/drugs/DB00787
DrugBank	DB00877	http://www.drugbank.ca/drugs/DB00877
DrugBank	DB01237	http://www.drugbank.ca/drugs/DB01237
EMBL	AK001709	http://www.ebi.ac.uk/ena/data/view/AK001709
EMBL	AK222625	http://www.ebi.ac.uk/ena/data/view/AK222625
EMBL	BC010661	http://www.ebi.ac.uk/ena/data/view/BC010661
EMBL	BC050592	http://www.ebi.ac.uk/ena/data/view/BC050592
EMBL	BC058882	http://www.ebi.ac.uk/ena/data/view/BC058882
EMBL	CH471212	http://www.ebi.ac.uk/ena/data/view/CH471212
EMBL	CH471212	http://www.ebi.ac.uk/ena/data/view/CH471212
Ensembl	ENST00000270570	http://www.ensembl.org/id/ENST00000270570
Ensembl	ENST00000395585	http://www.ensembl.org/id/ENST00000395585
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0031988	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031988
GO_function	GO:0005451	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005451
GO_function	GO:0015238	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015238
GO_function	GO:0015307	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015307
GO_process	GO:0006855	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006855
GO_process	GO:0015695	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015695
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC47A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC47A1
GeneID	55244	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55244
GeneTree	ENSGT00390000015713	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000015713
H-InvDB	HIX0013619	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0013619
HGNC	HGNC:25588	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:25588
HOGENOM	HOG000060313	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000060313&db=HOGENOM6
HOVERGEN	HBG056043	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG056043&db=HOVERGEN
HPA	HPA021987	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA021987
InParanoid	Q96FL8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96FL8
InterPro	IPR002528	http://www.ebi.ac.uk/interpro/entry/IPR002528
Jabion	55244	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55244
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:55244	http://www.genome.jp/dbget-bin/www_bget?hsa:55244
KEGG_Orthology	KO:K03327	http://www.genome.jp/dbget-bin/www_bget?KO:K03327
MIM	609832	http://www.ncbi.nlm.nih.gov/omim/609832
OMA	IMRTVIM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IMRTVIM
OrthoDB	EOG091G06X2	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G06X2
PSORT	swissprot:S47A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S47A1_HUMAN
PSORT-B	swissprot:S47A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S47A1_HUMAN
PSORT2	swissprot:S47A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S47A1_HUMAN
Pfam	PF01554	http://pfam.xfam.org/family/PF01554
PharmGKB	PA162403808	http://www.pharmgkb.org/do/serve?objId=PA162403808&objCls=Gene
Phobius	swissprot:S47A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S47A1_HUMAN
PhylomeDB	Q96FL8	http://phylomedb.org/?seqid=Q96FL8
ProteinModelPortal	Q96FL8	http://www.proteinmodelportal.org/query/uniprot/Q96FL8
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16330770	http://www.ncbi.nlm.nih.gov/pubmed/16330770
PubMed	16641166	http://www.ncbi.nlm.nih.gov/pubmed/16641166
PubMed	16996621	http://www.ncbi.nlm.nih.gov/pubmed/16996621
PubMed	17495125	http://www.ncbi.nlm.nih.gov/pubmed/17495125
PubMed	17509534	http://www.ncbi.nlm.nih.gov/pubmed/17509534
PubMed	17582384	http://www.ncbi.nlm.nih.gov/pubmed/17582384
PubMed	22814378	http://www.ncbi.nlm.nih.gov/pubmed/22814378
Reactome	R-HSA-425366	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425366
RefSeq	NP_060712	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060712
STRING	9606.ENSP00000270570	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000270570&targetmode=cogs
STRING	COG0534	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0534&targetmode=cogs
TCDB	2.A.66.1.14	http://www.tcdb.org/search/result.php?tc=2.A.66.1.14
TIGRFAMs	TIGR00797	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00797
UCSC	uc002gvx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002gvx&org=rat
UniGene	Hs.232054	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.232054
UniProtKB	S47A1_HUMAN	http://www.uniprot.org/uniprot/S47A1_HUMAN
UniProtKB-AC	Q96FL8	http://www.uniprot.org/uniprot/Q96FL8
charge	swissprot:S47A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S47A1_HUMAN
eggNOG	COG0534	http://eggnogapi.embl.de/nog_data/html/tree/COG0534
eggNOG	KOG1347	http://eggnogapi.embl.de/nog_data/html/tree/KOG1347
epestfind	swissprot:S47A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S47A1_HUMAN
garnier	swissprot:S47A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S47A1_HUMAN
helixturnhelix	swissprot:S47A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S47A1_HUMAN
hmoment	swissprot:S47A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S47A1_HUMAN
iep	swissprot:S47A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S47A1_HUMAN
inforesidue	swissprot:S47A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S47A1_HUMAN
neXtProt	NX_Q96FL8	http://www.nextprot.org/db/entry/NX_Q96FL8
octanol	swissprot:S47A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S47A1_HUMAN
pepcoil	swissprot:S47A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S47A1_HUMAN
pepdigest	swissprot:S47A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S47A1_HUMAN
pepinfo	swissprot:S47A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S47A1_HUMAN
pepnet	swissprot:S47A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S47A1_HUMAN
pepstats	swissprot:S47A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S47A1_HUMAN
pepwheel	swissprot:S47A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S47A1_HUMAN
pepwindow	swissprot:S47A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S47A1_HUMAN
sigcleave	swissprot:S47A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S47A1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	GRIA1_HUMAN	Event=Alternative splicing; Named isoforms=6; Name=Flop; IsoId=P42261-1; Sequence=Displayed; Name=Flip; IsoId=P42261-2; Sequence=VSP_053349; Name=3; IsoId=P42261-3; Sequence=VSP_045120; Name=4; IsoId=P42261-4; Sequence=VSP_045119; Name=5; IsoId=P42261-5; Sequence=VSP_047024; Note=No experimental confirmation available.; Name=6; IsoId=P42261-6; Sequence=VSP_047024, VSP_053349; Note=No experimental confirmation available.; 
# AltName	GRIA1_HUMAN	AMPA-selective glutamate receptor 1
# AltName	GRIA1_HUMAN	GluR-A
# AltName	GRIA1_HUMAN	GluR-K1
# AltName	GRIA1_HUMAN	Glutamate receptor ionotropic, AMPA 1
# BioGrid	109147	18
# CCDS	CCDS4322	-. [P42261-1]
# CCDS	CCDS47318	-. [P42261-2]
# CCDS	CCDS58986	-. [P42261-3]
# CCDS	CCDS58987	-. [P42261-5]
# CCDS	CCDS58988	-. [P42261-6]
# CCDS	CCDS58989	-. [P42261-4]
# ChiTaRS	GRIA1	human
# DOMAIN	GRIA1_HUMAN	The M4 transmembrane segment mediates tetramerization and is required for cell surface expression. 
# DrugBank	DB00228	Enflurane
# DrugBank	DB00753	Isoflurane
# DrugBank	DB00898	Ethanol
# DrugBank	DB01028	Methoxyflurane
# DrugBank	DB01189	Desflurane
# DrugBank	DB01236	Sevoflurane
# DrugBank	DB08883	Perampanel
# Ensembl	ENST00000285900	ENSP00000285900; ENSG00000155511. [P42261-1]
# Ensembl	ENST00000340592	ENSP00000339343; ENSG00000155511. [P42261-2]
# Ensembl	ENST00000448073	ENSP00000415569; ENSG00000155511. [P42261-6]
# Ensembl	ENST00000518142	ENSP00000427920; ENSG00000155511. [P42261-3]
# Ensembl	ENST00000518783	ENSP00000428994; ENSG00000155511. [P42261-5]
# Ensembl	ENST00000521843	ENSP00000427864; ENSG00000155511. [P42261-4]
# FUNCTION	GRIA1_HUMAN	Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. {ECO 0000269|PubMed 20805473, ECO 0000269|PubMed 21172611}. 
# GO_component	GO:0000139	Golgi membrane; IEA:GOC.
# GO_component	GO:0005789	endoplasmic reticulum membrane; TAS:Reactome.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0008021	synaptic vesicle; IEA:Ensembl.
# GO_component	GO:0009986	cell surface; ISS:BHF-UCL.
# GO_component	GO:0012507	ER to Golgi transport vesicle membrane; TAS:Reactome.
# GO_component	GO:0014069	postsynaptic density; ISS:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030425	dendrite; ISS:UniProtKB.
# GO_component	GO:0030666	endocytic vesicle membrane; TAS:Reactome.
# GO_component	GO:0032281	AMPA glutamate receptor complex; ISS:UniProtKB.
# GO_component	GO:0032591	dendritic spine membrane; IDA:UniProtKB.
# GO_component	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane; TAS:Reactome.
# GO_component	GO:0043025	neuronal cell body; ISS:BHF-UCL.
# GO_component	GO:0043197	dendritic spine; ISS:UniProtKB.
# GO_component	GO:0044308	axonal spine; IEA:Ensembl.
# GO_component	GO:0044309	neuron spine; ISS:BHF-UCL.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0055037	recycling endosome; IDA:UniProtKB.
# GO_function	GO:0004971	AMPA glutamate receptor activity; IDA:UniProtKB.
# GO_function	GO:0005231	excitatory extracellular ligand-gated ion channel activity; TAS:Reactome.
# GO_function	GO:0005234	extracellular-glutamate-gated ion channel activity; IEA:InterPro.
# GO_function	GO:0008066	glutamate receptor activity; TAS:ProtInc.
# GO_function	GO:0030165	PDZ domain binding; ISS:BHF-UCL.
# GO_process	GO:0006888	ER to Golgi vesicle-mediated transport; TAS:Reactome.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:Reactome.
# GO_process	GO:0007616	long-term memory; IEA:Ensembl.
# GO_process	GO:0031623	receptor internalization; IEA:Ensembl.
# GO_process	GO:0048208	COPII vesicle coating; TAS:Reactome.
# GO_process	GO:0060292	long term synaptic depression; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0050877	neurological system process
# Genevisible	P42261	HS
# HGNC	HGNC:4571	GRIA1
# InterPro	IPR001320	Iontro_rcpt
# InterPro	IPR001508	Iono_rcpt_met
# InterPro	IPR001828	ANF_lig-bd_rcpt
# InterPro	IPR019594	Glu/Gly-bd
# InterPro	IPR028082	Peripla_BP_I
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04713	Circadian entrainment
# KEGG_Pathway	ko04720	Long-term potentiation
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04724	Glutamatergic synapse
# KEGG_Pathway	ko04728	Dopaminergic synapse
# KEGG_Pathway	ko04730	Long-term depression
# KEGG_Pathway	ko05014	Amyotrophic lateral sclerosis (ALS)
# KEGG_Pathway	ko05031	Amphetamine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# MIM	138248	gene
# MISCELLANEOUS	GRIA1_HUMAN	The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate. 
# Organism	GRIA1_HUMAN	Homo sapiens (Human)
# PIR	A40222	A40222
# PIR	A41273	A41273
# PIR	S25852	S25852
# PIR	S38723	S38723
# PRINTS	PR00177	NMDARECEPTOR
# PTM	GRIA1_HUMAN	Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity). {ECO 0000250}. 
# Pfam	PF00060	Lig_chan
# Pfam	PF01094	ANF_receptor
# Pfam	PF10613	Lig_chan-Glu_bd
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-204005	COPII (Coat Protein 2) Mediated Vesicle Transport
# Reactome	R-HSA-399710	Activation of AMPA receptors
# Reactome	R-HSA-399719	Trafficking of AMPA receptors
# Reactome	R-HSA-416993	Trafficking of GluR2-containing AMPA receptors
# Reactome	R-HSA-438066	Unblocking of NMDA receptor, glutamate binding and activation
# Reactome	R-HSA-5694530	Cargo concentration in the ER
# Reactome	R-HSA-8849932	SALM protein interactions at the synapses
# RecName	GRIA1_HUMAN	Glutamate receptor 1
# RefSeq	NP_000818	NM_000827.3. [P42261-1]
# RefSeq	NP_001107655	NM_001114183.1. [P42261-2]
# RefSeq	NP_001244948	NM_001258019.1. [P42261-3]
# RefSeq	NP_001244950	NM_001258021.1. [P42261-5]
# RefSeq	NP_001244951	NM_001258022.1. [P42261-6]
# RefSeq	NP_001244952	NM_001258023.1. [P42261-4]
# SIMILARITY	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA1 subfamily. {ECO	0000305}.
# SMART	SM00079	PBPe
# SMART	SM00918	Lig_chan-Glu_bd
# SUBCELLULAR LOCATION	GRIA1_HUMAN	Cell membrane {ECO 0000269|PubMed 23739980}; Multi-pass membrane protein {ECO 0000269|PubMed 23739980}. Endoplasmic reticulum membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO 0000269|PubMed 23739980}; Multi-pass membrane protein {ECO 0000269|PubMed 23739980}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO 0000250}. Cell projection, dendrite {ECO 0000250}. Cell projection, dendritic spine {ECO 0000250}. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. {ECO 0000250}. 
# SUBUNIT	GRIA1_HUMAN	Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with DLG1 via its C-terminus. Found in a complex with GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with HIP1, RASGRF2, SYNDIG1 and LRFN1. Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes. Interacts (via PDZ-binding motif) with SHANK3 (via PDZ domain). {ECO 0000269|PubMed 20805473, ECO 0000269|PubMed 23739980}. 
# SUPFAM	SSF53822	SSF53822
# TISSUE SPECIFICITY	GRIA1_HUMAN	Widely expressed in brain. 
# UCSC	uc003luy	human. [P42261-1]
# eggNOG	ENOG410XPSH	LUCA
# eggNOG	KOG1054	Eukaryota
BLAST	swissprot:GRIA1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GRIA1_HUMAN
BioCyc	ZFISH:ENSG00000155511-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000155511-MONOMER
COXPRESdb	2890	http://coxpresdb.jp/data/gene/2890.shtml
CleanEx	HS_GRIA1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GRIA1
DIP	DIP-41487N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-41487N
DOI	10.1016/j.neuron.2010.11.026	http://dx.doi.org/10.1016/j.neuron.2010.11.026
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.1011706107	http://dx.doi.org/10.1073/pnas.1011706107
DOI	10.1073/pnas.88.17.7557	http://dx.doi.org/10.1073/pnas.88.17.7557
DOI	10.1073/pnas.89.4.1443	http://dx.doi.org/10.1073/pnas.89.4.1443
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1523/JNEUROSCI.2626-12.2013	http://dx.doi.org/10.1523/JNEUROSCI.2626-12.2013
DrugBank	DB00228	http://www.drugbank.ca/drugs/DB00228
DrugBank	DB00753	http://www.drugbank.ca/drugs/DB00753
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01028	http://www.drugbank.ca/drugs/DB01028
DrugBank	DB01189	http://www.drugbank.ca/drugs/DB01189
DrugBank	DB01236	http://www.drugbank.ca/drugs/DB01236
DrugBank	DB08883	http://www.drugbank.ca/drugs/DB08883
EMBL	AC010613	http://www.ebi.ac.uk/ena/data/view/AC010613
EMBL	AC025156	http://www.ebi.ac.uk/ena/data/view/AC025156
EMBL	AC091960	http://www.ebi.ac.uk/ena/data/view/AC091960
EMBL	AC091962	http://www.ebi.ac.uk/ena/data/view/AC091962
EMBL	AK295039	http://www.ebi.ac.uk/ena/data/view/AK295039
EMBL	AK295184	http://www.ebi.ac.uk/ena/data/view/AK295184
EMBL	AK295827	http://www.ebi.ac.uk/ena/data/view/AK295827
EMBL	AK315934	http://www.ebi.ac.uk/ena/data/view/AK315934
EMBL	BC111734	http://www.ebi.ac.uk/ena/data/view/BC111734
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	M64752	http://www.ebi.ac.uk/ena/data/view/M64752
EMBL	M81886	http://www.ebi.ac.uk/ena/data/view/M81886
EMBL	X58633	http://www.ebi.ac.uk/ena/data/view/X58633
Ensembl	ENST00000285900	http://www.ensembl.org/id/ENST00000285900
Ensembl	ENST00000340592	http://www.ensembl.org/id/ENST00000340592
Ensembl	ENST00000448073	http://www.ensembl.org/id/ENST00000448073
Ensembl	ENST00000518142	http://www.ensembl.org/id/ENST00000518142
Ensembl	ENST00000518783	http://www.ensembl.org/id/ENST00000518783
Ensembl	ENST00000521843	http://www.ensembl.org/id/ENST00000521843
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008021
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0012507	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0012507
GO_component	GO:0014069	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014069
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0030666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030666
GO_component	GO:0032281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032281
GO_component	GO:0032591	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032591
GO_component	GO:0033116	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033116
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0043197	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043197
GO_component	GO:0044308	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044308
GO_component	GO:0044309	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044309
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_component	GO:0055037	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055037
GO_function	GO:0004971	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004971
GO_function	GO:0005231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005231
GO_function	GO:0005234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005234
GO_function	GO:0008066	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008066
GO_function	GO:0030165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030165
GO_process	GO:0006888	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006888
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007616	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007616
GO_process	GO:0031623	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031623
GO_process	GO:0048208	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048208
GO_process	GO:0060292	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060292
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	GRIA1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GRIA1
GeneID	2890	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2890
GeneTree	ENSGT00760000118920	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118920
H-InvDB	HIX0032120	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0032120
HGNC	HGNC:4571	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4571
HOGENOM	HOG000234372	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234372&db=HOGENOM6
HOVERGEN	HBG051839	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051839&db=HOVERGEN
HPA	CAB001965	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB001965
HPA	HPA035202	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035202
InParanoid	P42261	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P42261
InterPro	IPR001320	http://www.ebi.ac.uk/interpro/entry/IPR001320
InterPro	IPR001508	http://www.ebi.ac.uk/interpro/entry/IPR001508
InterPro	IPR001828	http://www.ebi.ac.uk/interpro/entry/IPR001828
InterPro	IPR019594	http://www.ebi.ac.uk/interpro/entry/IPR019594
InterPro	IPR028082	http://www.ebi.ac.uk/interpro/entry/IPR028082
Jabion	2890	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2890
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:2890	http://www.genome.jp/dbget-bin/www_bget?hsa:2890
KEGG_Orthology	KO:K05197	http://www.genome.jp/dbget-bin/www_bget?KO:K05197
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04713	http://www.genome.jp/kegg-bin/show_pathway?ko04713
KEGG_Pathway	ko04720	http://www.genome.jp/kegg-bin/show_pathway?ko04720
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
KEGG_Pathway	ko04728	http://www.genome.jp/kegg-bin/show_pathway?ko04728
KEGG_Pathway	ko04730	http://www.genome.jp/kegg-bin/show_pathway?ko04730
KEGG_Pathway	ko05014	http://www.genome.jp/kegg-bin/show_pathway?ko05014
KEGG_Pathway	ko05031	http://www.genome.jp/kegg-bin/show_pathway?ko05031
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
MIM	138248	http://www.ncbi.nlm.nih.gov/omim/138248
MINT	MINT-271172	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-271172
OMA	MQRSFTI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MQRSFTI
OrthoDB	EOG091G11CB	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G11CB
PRINTS	PR00177	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00177
PSORT	swissprot:GRIA1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GRIA1_HUMAN
PSORT-B	swissprot:GRIA1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GRIA1_HUMAN
PSORT2	swissprot:GRIA1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GRIA1_HUMAN
Pfam	PF00060	http://pfam.xfam.org/family/PF00060
Pfam	PF01094	http://pfam.xfam.org/family/PF01094
Pfam	PF10613	http://pfam.xfam.org/family/PF10613
PharmGKB	PA28966	http://www.pharmgkb.org/do/serve?objId=PA28966&objCls=Gene
Phobius	swissprot:GRIA1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GRIA1_HUMAN
PhylomeDB	P42261	http://phylomedb.org/?seqid=P42261
ProteinModelPortal	P42261	http://www.proteinmodelportal.org/query/uniprot/P42261
PubMed	1311100	http://www.ncbi.nlm.nih.gov/pubmed/1311100
PubMed	1320959	http://www.ncbi.nlm.nih.gov/pubmed/1320959
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	1652753	http://www.ncbi.nlm.nih.gov/pubmed/1652753
PubMed	20805473	http://www.ncbi.nlm.nih.gov/pubmed/20805473
PubMed	21172611	http://www.ncbi.nlm.nih.gov/pubmed/21172611
PubMed	23739980	http://www.ncbi.nlm.nih.gov/pubmed/23739980
Reactome	R-HSA-204005	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-204005
Reactome	R-HSA-399710	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-399710
Reactome	R-HSA-399719	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-399719
Reactome	R-HSA-416993	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-416993
Reactome	R-HSA-438066	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-438066
Reactome	R-HSA-5694530	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5694530
Reactome	R-HSA-8849932	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8849932
RefSeq	NP_000818	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000818
RefSeq	NP_001107655	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001107655
RefSeq	NP_001244948	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001244948
RefSeq	NP_001244950	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001244950
RefSeq	NP_001244951	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001244951
RefSeq	NP_001244952	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001244952
SMART	SM00079	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00079
SMART	SM00918	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00918
SMR	P42261	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P42261
STRING	9606.ENSP00000285900	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000285900&targetmode=cogs
SUPFAM	SSF53822	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822
UCSC	uc003luy	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003luy&org=rat
UniGene	Hs.519693	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.519693
UniGene	Hs.737709	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.737709
UniProtKB	GRIA1_HUMAN	http://www.uniprot.org/uniprot/GRIA1_HUMAN
UniProtKB-AC	P42261	http://www.uniprot.org/uniprot/P42261
charge	swissprot:GRIA1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GRIA1_HUMAN
eggNOG	ENOG410XPSH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPSH
eggNOG	KOG1054	http://eggnogapi.embl.de/nog_data/html/tree/KOG1054
epestfind	swissprot:GRIA1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GRIA1_HUMAN
garnier	swissprot:GRIA1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GRIA1_HUMAN
helixturnhelix	swissprot:GRIA1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GRIA1_HUMAN
hmoment	swissprot:GRIA1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GRIA1_HUMAN
iep	swissprot:GRIA1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GRIA1_HUMAN
inforesidue	swissprot:GRIA1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GRIA1_HUMAN
neXtProt	NX_P42261	http://www.nextprot.org/db/entry/NX_P42261
octanol	swissprot:GRIA1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GRIA1_HUMAN
pepcoil	swissprot:GRIA1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GRIA1_HUMAN
pepdigest	swissprot:GRIA1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GRIA1_HUMAN
pepinfo	swissprot:GRIA1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GRIA1_HUMAN
pepnet	swissprot:GRIA1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GRIA1_HUMAN
pepstats	swissprot:GRIA1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GRIA1_HUMAN
pepwheel	swissprot:GRIA1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GRIA1_HUMAN
pepwindow	swissprot:GRIA1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GRIA1_HUMAN
sigcleave	swissprot:GRIA1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GRIA1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	MCLN3_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8TDD5-1; Sequence=Displayed; Name=2; IsoId=Q8TDD5-2; Sequence=VSP_010823; 
# BioGrid	120571	57
# CCDS	CCDS58009	-. [Q8TDD5-2]
# CCDS	CCDS701	-. [Q8TDD5-1]
# Ensembl	ENST00000341115	ENSP00000342698; ENSG00000055732. [Q8TDD5-2]
# Ensembl	ENST00000370589	ENSP00000359621; ENSG00000055732. [Q8TDD5-1]
# ExpressionAtlas	Q8TDD5	baseline and differential
# GO_component	GO:0005737	cytoplasm; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005262	calcium channel activity; TAS:Reactome.
# GO_process	GO:0007626	locomotory behavior; IEA:Ensembl.
# GO_process	GO:0042491	auditory receptor cell differentiation; IEA:Ensembl.
# GO_process	GO:0070588	calcium ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q8TDD5	HS
# HGNC	HGNC:13358	MCOLN3
# InterPro	IPR013122	PKD1_2_channel
# KEGG_Brite	ko04040	Ion channels
# MIM	607400	gene
# Organism	MCLN3_HUMAN	Homo sapiens (Human)
# Pfam	PF08016	PKD_channel
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-3295583	TRP channels
# RecName	MCLN3_HUMAN	Mucolipin-3
# RefSeq	NP_001240622	NM_001253693.1. [Q8TDD5-2]
# RefSeq	NP_060768	NM_018298.10. [Q8TDD5-1]
# RefSeq	XP_005271060	XM_005271003.1. [Q8TDD5-1]
# RefSeq	XP_006710813	XM_006710750.1. [Q8TDD5-1]
# SIMILARITY	Belongs to the transient receptor (TC 1.A.4) family. Polycystin subfamily. MCOLN3 sub-subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	MCLN3_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	1.A.5.3	the polycystin cation channel (pcc) family
# UCSC	uc001dkp	human. [Q8TDD5-1]
# eggNOG	ENOG410Z1HH	LUCA
# eggNOG	KOG3733	Eukaryota
BLAST	swissprot:MCLN3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MCLN3_HUMAN
COXPRESdb	55283	http://coxpresdb.jp/data/gene/55283.shtml
CleanEx	HS_MCOLN3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_MCOLN3
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
EMBL	AF475085	http://www.ebi.ac.uk/ena/data/view/AF475085
EMBL	AK001868	http://www.ebi.ac.uk/ena/data/view/AK001868
EMBL	AL358789	http://www.ebi.ac.uk/ena/data/view/AL358789
EMBL	AL358789	http://www.ebi.ac.uk/ena/data/view/AL358789
Ensembl	ENST00000341115	http://www.ensembl.org/id/ENST00000341115
Ensembl	ENST00000370589	http://www.ensembl.org/id/ENST00000370589
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_process	GO:0007626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007626
GO_process	GO:0042491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042491
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	MCOLN3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=MCOLN3
GeneID	55283	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55283
GeneTree	ENSGT00390000017126	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000017126
HGNC	HGNC:13358	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13358
HOGENOM	HOG000232158	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000232158&db=HOGENOM6
HOVERGEN	HBG052430	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052430&db=HOVERGEN
HPA	HPA018106	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA018106
HPA	HPA062137	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA062137
InParanoid	Q8TDD5	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8TDD5
IntAct	Q8TDD5	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8TDD5*
InterPro	IPR013122	http://www.ebi.ac.uk/interpro/entry/IPR013122
Jabion	55283	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55283
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:55283	http://www.genome.jp/dbget-bin/www_bget?hsa:55283
KEGG_Orthology	KO:K04994	http://www.genome.jp/dbget-bin/www_bget?KO:K04994
MIM	607400	http://www.ncbi.nlm.nih.gov/omim/607400
OMA	ETECFFV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ETECFFV
OrthoDB	EOG091G026A	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G026A
PSORT	swissprot:MCLN3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MCLN3_HUMAN
PSORT-B	swissprot:MCLN3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MCLN3_HUMAN
PSORT2	swissprot:MCLN3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MCLN3_HUMAN
Pfam	PF08016	http://pfam.xfam.org/family/PF08016
PharmGKB	PA134947324	http://www.pharmgkb.org/do/serve?objId=PA134947324&objCls=Gene
Phobius	swissprot:MCLN3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MCLN3_HUMAN
PhylomeDB	Q8TDD5	http://phylomedb.org/?seqid=Q8TDD5
ProteinModelPortal	Q8TDD5	http://www.proteinmodelportal.org/query/uniprot/Q8TDD5
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
Reactome	R-HSA-3295583	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3295583
RefSeq	NP_001240622	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001240622
RefSeq	NP_060768	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060768
RefSeq	XP_005271060	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005271060
RefSeq	XP_006710813	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006710813
STRING	9606.ENSP00000304843	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000304843&targetmode=cogs
TCDB	1.A.5.3	http://www.tcdb.org/search/result.php?tc=1.A.5.3
UCSC	uc001dkp	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001dkp&org=rat
UniGene	Hs.535239	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.535239
UniProtKB	MCLN3_HUMAN	http://www.uniprot.org/uniprot/MCLN3_HUMAN
UniProtKB-AC	Q8TDD5	http://www.uniprot.org/uniprot/Q8TDD5
charge	swissprot:MCLN3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MCLN3_HUMAN
eggNOG	ENOG410Z1HH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z1HH
eggNOG	KOG3733	http://eggnogapi.embl.de/nog_data/html/tree/KOG3733
epestfind	swissprot:MCLN3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MCLN3_HUMAN
garnier	swissprot:MCLN3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MCLN3_HUMAN
helixturnhelix	swissprot:MCLN3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MCLN3_HUMAN
hmoment	swissprot:MCLN3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MCLN3_HUMAN
iep	swissprot:MCLN3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MCLN3_HUMAN
inforesidue	swissprot:MCLN3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MCLN3_HUMAN
neXtProt	NX_Q8TDD5	http://www.nextprot.org/db/entry/NX_Q8TDD5
octanol	swissprot:MCLN3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MCLN3_HUMAN
pepcoil	swissprot:MCLN3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MCLN3_HUMAN
pepdigest	swissprot:MCLN3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MCLN3_HUMAN
pepinfo	swissprot:MCLN3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MCLN3_HUMAN
pepnet	swissprot:MCLN3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MCLN3_HUMAN
pepstats	swissprot:MCLN3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MCLN3_HUMAN
pepwheel	swissprot:MCLN3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MCLN3_HUMAN
pepwindow	swissprot:MCLN3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MCLN3_HUMAN
sigcleave	swissprot:MCLN3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MCLN3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S12A7_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y666-1; Sequence=Displayed; Name=2; IsoId=Q9Y666-2; Sequence=VSP_006119, VSP_006120; Note=No experimental confirmation available.; 
# AltName	S12A7_HUMAN	Electroneutral potassium-chloride cotransporter 4
# AltName	S12A7_HUMAN	K-Cl cotransporter 4
# BioGrid	115947	15
# CCDS	CCDS34129	-. [Q9Y666-1]
# ChiTaRS	SLC12A7	human
# DrugBank	DB00761	Potassium Chloride
# ENZYME REGULATION	Activated by N-ethylmaleimide (NEM). Inhibited by furosemide, DIDS and bumetanide. The inhibition is much stronger in the presence of 50 mM K(+) in the uptake medium. Inhibited by DIOA. Inhibited by WNK3. {ECO:0000269|PubMed	21613606}. 
# Ensembl	ENST00000264930	ENSP00000264930; ENSG00000113504. [Q9Y666-1]
# ExpressionAtlas	Q9Y666	baseline and differential
# FUNCTION	S12A7_HUMAN	Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity). {ECO 0000250, ECO 0000269|PubMed 10913127}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_function	GO:0019901	protein kinase binding; IPI:ParkinsonsUK-UCL.
# GO_function	GO:0022820	potassium ion symporter activity; IBA:GO_Central.
# GO_function	S12A7_HUMAN	GO 0015379 potassium chloride symporter activity; TAS Reactome.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006884	cell volume homeostasis; IEA:InterPro.
# GO_process	GO:0007268	chemical synaptic transmission; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0042592	homeostatic process
# Genevisible	Q9Y666	HS
# HGNC	HGNC:10915	SLC12A7
# InterPro	IPR000076	KCL_cotranspt
# InterPro	IPR004841	AA-permease/SLC12A_dom
# InterPro	IPR004842	SLC12A_fam
# InterPro	IPR018491	SLC12_C
# InterPro	IPR030354	KCC4
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04966	Collecting duct acid secretion
# MIM	604879	gene
# Organism	S12A7_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11827:SF47	PTHR11827:SF47; 4
# PIR	T17231	T17231
# PRINTS	PR01081	KCLTRNSPORT
# Pfam	PF00324	AA_permease; 2
# Pfam	PF03522	SLC12; 2
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-426117	Cation-coupled Chloride cotransporters
# RecName	S12A7_HUMAN	Solute carrier family 12 member 7
# RefSeq	NP_006589	NM_006598.2. [Q9Y666-1]
# SIMILARITY	Belongs to the SLC12A transporter family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S12A7_HUMAN	Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Homomultimer and heteromultimer with other K-Cl cotransporters. {ECO	0000250}. 
# TCDB	2.A.30.5	the cation-chloride cotransporter (ccc) family
# TIGRFAMs	TIGR00930	2a30
# TISSUE SPECIFICITY	S12A7_HUMAN	Detected in muscle, brain, lung, heart and kidney. 
# UCSC	uc003jbu	human. [Q9Y666-1]
# eggNOG	COG0531	LUCA
# eggNOG	KOG2082	Eukaryota
BLAST	swissprot:S12A7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S12A7_HUMAN
BioCyc	ZFISH:ENSG00000113504-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000113504-MONOMER
COXPRESdb	10723	http://coxpresdb.jp/data/gene/10723.shtml
CleanEx	HS_SLC12A7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC12A7
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature02919	http://dx.doi.org/10.1038/nature02919
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/jbc.274.23.16355	http://dx.doi.org/10.1074/jbc.274.23.16355
DOI	10.1074/jbc.M003112200	http://dx.doi.org/10.1074/jbc.M003112200
DOI	10.1093/dnares/7.6.357	http://dx.doi.org/10.1093/dnares/7.6.357
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1152/ajpcell.00070.2011	http://dx.doi.org/10.1152/ajpcell.00070.2011
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DrugBank	DB00761	http://www.drugbank.ca/drugs/DB00761
EMBL	AC116351	http://www.ebi.ac.uk/ena/data/view/AC116351
EMBL	AF105365	http://www.ebi.ac.uk/ena/data/view/AF105365
EMBL	AK024493	http://www.ebi.ac.uk/ena/data/view/AK024493
EMBL	AK024497	http://www.ebi.ac.uk/ena/data/view/AK024497
EMBL	AL117433	http://www.ebi.ac.uk/ena/data/view/AL117433
EMBL	BC007760	http://www.ebi.ac.uk/ena/data/view/BC007760
EMBL	BC098390	http://www.ebi.ac.uk/ena/data/view/BC098390
Ensembl	ENST00000264930	http://www.ensembl.org/id/ENST00000264930
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0015379	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015379
GO_function	GO:0019901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019901
GO_function	GO:0022820	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022820
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006884	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006884
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GeneCards	SLC12A7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC12A7
GeneID	10723	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10723
GeneTree	ENSGT00760000119053	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119053
H-InvDB	HIX0004714	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0004714
HGNC	HGNC:10915	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10915
HOGENOM	HOG000092644	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000092644&db=HOGENOM6
HOVERGEN	HBG052852	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052852&db=HOVERGEN
HPA	HPA041652	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA041652
InParanoid	Q9Y666	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y666
IntAct	Q9Y666	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9Y666*
InterPro	IPR000076	http://www.ebi.ac.uk/interpro/entry/IPR000076
InterPro	IPR004841	http://www.ebi.ac.uk/interpro/entry/IPR004841
InterPro	IPR004842	http://www.ebi.ac.uk/interpro/entry/IPR004842
InterPro	IPR018491	http://www.ebi.ac.uk/interpro/entry/IPR018491
InterPro	IPR030354	http://www.ebi.ac.uk/interpro/entry/IPR030354
Jabion	10723	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10723
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:10723	http://www.genome.jp/dbget-bin/www_bget?hsa:10723
KEGG_Orthology	KO:K13627	http://www.genome.jp/dbget-bin/www_bget?KO:K13627
KEGG_Pathway	ko04966	http://www.genome.jp/kegg-bin/show_pathway?ko04966
MIM	604879	http://www.ncbi.nlm.nih.gov/omim/604879
MINT	MINT-4658387	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4658387
OMA	TASHSAM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TASHSAM
OrthoDB	EOG091G0WB4	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0WB4
PANTHER	PTHR11827:SF47	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11827:SF47
PRINTS	PR01081	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01081
PSORT	swissprot:S12A7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S12A7_HUMAN
PSORT-B	swissprot:S12A7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S12A7_HUMAN
PSORT2	swissprot:S12A7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S12A7_HUMAN
Pfam	PF00324	http://pfam.xfam.org/family/PF00324
Pfam	PF03522	http://pfam.xfam.org/family/PF03522
PharmGKB	PA35809	http://www.pharmgkb.org/do/serve?objId=PA35809&objCls=Gene
Phobius	swissprot:S12A7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S12A7_HUMAN
PhylomeDB	Q9Y666	http://phylomedb.org/?seqid=Q9Y666
ProteinModelPortal	Q9Y666	http://www.proteinmodelportal.org/query/uniprot/Q9Y666
PubMed	10347194	http://www.ncbi.nlm.nih.gov/pubmed/10347194
PubMed	10913127	http://www.ncbi.nlm.nih.gov/pubmed/10913127
PubMed	11214971	http://www.ncbi.nlm.nih.gov/pubmed/11214971
PubMed	15372022	http://www.ncbi.nlm.nih.gov/pubmed/15372022
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	21613606	http://www.ncbi.nlm.nih.gov/pubmed/21613606
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
Reactome	R-HSA-426117	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-426117
RefSeq	NP_006589	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006589
STRING	9606.ENSP00000264930	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000264930&targetmode=cogs
TCDB	2.A.30.5	http://www.tcdb.org/search/result.php?tc=2.A.30.5
TIGRFAMs	TIGR00930	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00930
UCSC	uc003jbu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003jbu&org=rat
UniGene	Hs.172613	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.172613
UniProtKB	S12A7_HUMAN	http://www.uniprot.org/uniprot/S12A7_HUMAN
UniProtKB-AC	Q9Y666	http://www.uniprot.org/uniprot/Q9Y666
charge	swissprot:S12A7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S12A7_HUMAN
eggNOG	COG0531	http://eggnogapi.embl.de/nog_data/html/tree/COG0531
eggNOG	KOG2082	http://eggnogapi.embl.de/nog_data/html/tree/KOG2082
epestfind	swissprot:S12A7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S12A7_HUMAN
garnier	swissprot:S12A7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S12A7_HUMAN
helixturnhelix	swissprot:S12A7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S12A7_HUMAN
hmoment	swissprot:S12A7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S12A7_HUMAN
iep	swissprot:S12A7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S12A7_HUMAN
inforesidue	swissprot:S12A7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S12A7_HUMAN
neXtProt	NX_Q9Y666	http://www.nextprot.org/db/entry/NX_Q9Y666
octanol	swissprot:S12A7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S12A7_HUMAN
pepcoil	swissprot:S12A7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S12A7_HUMAN
pepdigest	swissprot:S12A7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S12A7_HUMAN
pepinfo	swissprot:S12A7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S12A7_HUMAN
pepnet	swissprot:S12A7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S12A7_HUMAN
pepstats	swissprot:S12A7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S12A7_HUMAN
pepwheel	swissprot:S12A7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S12A7_HUMAN
pepwindow	swissprot:S12A7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S12A7_HUMAN
sigcleave	swissprot:S12A7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S12A7_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TTYH2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BSA4-1; Sequence=Displayed; Name=2; IsoId=Q9BSA4-2; Sequence=VSP_040567; Note=No experimental confirmation available.; 
# BioGrid	125087	5
# CCDS	CCDS32717	-. [Q9BSA4-1]
# CCDS	CCDS45770	-. [Q9BSA4-2]
# CDD	cd07912	Tweety_N
# ChiTaRS	TTYH2	human
# Ensembl	ENST00000269346	ENSP00000269346; ENSG00000141540. [Q9BSA4-1]
# Ensembl	ENST00000441391	ENSP00000394576; ENSG00000141540. [Q9BSA4-2]
# ExpressionAtlas	Q9BSA4	baseline and differential
# FUNCTION	TTYH2_HUMAN	Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. May be involved in cell proliferation and cell aggregation. {ECO 0000269|PubMed 15010458}. 
# GO_component	GO:0005886	plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_function	GO:0005254	chloride channel activity; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# Genevisible	Q9BSA4	HS
# HGNC	HGNC:13877	TTYH2
# IntAct	Q9BSA4	3
# InterPro	IPR006990	Tweety
# MIM	608855	gene
# Organism	TTYH2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12424	PTHR12424
# Pfam	PF04906	Tweety
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	TTYH2_HUMAN	Protein tweety homolog 2
# RefSeq	NP_116035	NM_032646.5. [Q9BSA4-1]
# RefSeq	NP_443101	NM_052869.1. [Q9BSA4-2]
# SEQUENCE CAUTION	Sequence=AAH05168.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC03579.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the tweety family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	TTYH2_HUMAN	Cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# TCDB	1.A.48.1	the anion channel tweety (tweety) family
# TISSUE SPECIFICITY	TTYH2_HUMAN	Expressed at higher level in brain and testis and at lower levels in heart, ovary, spleen and peripheral blood leukocytes. Up-regulated in 13 of 16 renal cell carcinoma samples examined. Up-regulated in colon carcinoma. {ECO 0000269|PubMed 11597145, ECO 0000269|PubMed 17569141}. 
# UCSC	uc002jkc	human. [Q9BSA4-1]
# eggNOG	ENOG410ZNTN	LUCA
# eggNOG	KOG4433	Eukaryota
BLAST	swissprot:TTYH2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TTYH2_HUMAN
BioCyc	ZFISH:ENSG00000141540-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000141540-MONOMER
COXPRESdb	94015	http://coxpresdb.jp/data/gene/94015.shtml
CleanEx	HS_TTYH2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TTYH2
DOI	10.1006/geno.2001.6629	http://dx.doi.org/10.1006/geno.2001.6629
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M313813200	http://dx.doi.org/10.1074/jbc.M313813200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.3748/wjg.v13.i19.2717	http://dx.doi.org/10.3748/wjg.v13.i19.2717
EMBL	AC100786	http://www.ebi.ac.uk/ena/data/view/AC100786
EMBL	AF319952	http://www.ebi.ac.uk/ena/data/view/AF319952
EMBL	AK091085	http://www.ebi.ac.uk/ena/data/view/AK091085
EMBL	AK126955	http://www.ebi.ac.uk/ena/data/view/AK126955
EMBL	BC005168	http://www.ebi.ac.uk/ena/data/view/BC005168
EMBL	BC107492	http://www.ebi.ac.uk/ena/data/view/BC107492
EMBL	BC107602	http://www.ebi.ac.uk/ena/data/view/BC107602
EMBL	BX647912	http://www.ebi.ac.uk/ena/data/view/BX647912
Ensembl	ENST00000269346	http://www.ensembl.org/id/ENST00000269346
Ensembl	ENST00000441391	http://www.ensembl.org/id/ENST00000441391
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GeneCards	TTYH2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TTYH2
GeneID	94015	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=94015
GeneTree	ENSGT00390000010182	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000010182
HGNC	HGNC:13877	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13877
HOVERGEN	HBG102014	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG102014&db=HOVERGEN
InParanoid	Q9BSA4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9BSA4
IntAct	Q9BSA4	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9BSA4*
InterPro	IPR006990	http://www.ebi.ac.uk/interpro/entry/IPR006990
Jabion	94015	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=94015
KEGG_Gene	hsa:94015	http://www.genome.jp/dbget-bin/www_bget?hsa:94015
MIM	608855	http://www.ncbi.nlm.nih.gov/omim/608855
MINT	MINT-2814893	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-2814893
OMA	RSKCLLA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RSKCLLA
OrthoDB	EOG091G05MR	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05MR
PANTHER	PTHR12424	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12424
PSORT	swissprot:TTYH2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TTYH2_HUMAN
PSORT-B	swissprot:TTYH2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TTYH2_HUMAN
PSORT2	swissprot:TTYH2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TTYH2_HUMAN
Pfam	PF04906	http://pfam.xfam.org/family/PF04906
PharmGKB	PA37823	http://www.pharmgkb.org/do/serve?objId=PA37823&objCls=Gene
Phobius	swissprot:TTYH2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TTYH2_HUMAN
PhylomeDB	Q9BSA4	http://phylomedb.org/?seqid=Q9BSA4
ProteinModelPortal	Q9BSA4	http://www.proteinmodelportal.org/query/uniprot/Q9BSA4
PubMed	11597145	http://www.ncbi.nlm.nih.gov/pubmed/11597145
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15010458	http://www.ncbi.nlm.nih.gov/pubmed/15010458
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	17569141	http://www.ncbi.nlm.nih.gov/pubmed/17569141
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_116035	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_116035
RefSeq	NP_443101	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_443101
STRING	9606.ENSP00000269346	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000269346&targetmode=cogs
TCDB	1.A.48.1	http://www.tcdb.org/search/result.php?tc=1.A.48.1
UCSC	uc002jkc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002jkc&org=rat
UniGene	Hs.27935	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.27935
UniProtKB	TTYH2_HUMAN	http://www.uniprot.org/uniprot/TTYH2_HUMAN
UniProtKB-AC	Q9BSA4	http://www.uniprot.org/uniprot/Q9BSA4
charge	swissprot:TTYH2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TTYH2_HUMAN
eggNOG	ENOG410ZNTN	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZNTN
eggNOG	KOG4433	http://eggnogapi.embl.de/nog_data/html/tree/KOG4433
epestfind	swissprot:TTYH2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TTYH2_HUMAN
garnier	swissprot:TTYH2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TTYH2_HUMAN
helixturnhelix	swissprot:TTYH2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TTYH2_HUMAN
hmoment	swissprot:TTYH2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TTYH2_HUMAN
iep	swissprot:TTYH2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TTYH2_HUMAN
inforesidue	swissprot:TTYH2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TTYH2_HUMAN
neXtProt	NX_Q9BSA4	http://www.nextprot.org/db/entry/NX_Q9BSA4
octanol	swissprot:TTYH2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TTYH2_HUMAN
pepcoil	swissprot:TTYH2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TTYH2_HUMAN
pepdigest	swissprot:TTYH2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TTYH2_HUMAN
pepinfo	swissprot:TTYH2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TTYH2_HUMAN
pepnet	swissprot:TTYH2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TTYH2_HUMAN
pepstats	swissprot:TTYH2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TTYH2_HUMAN
pepwheel	swissprot:TTYH2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TTYH2_HUMAN
pepwindow	swissprot:TTYH2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TTYH2_HUMAN
sigcleave	swissprot:TTYH2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TTYH2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNH2_HUMAN	Event=Alternative splicing; Named isoforms=6; Comment=Experimental confirmation may be lacking for some isoforms.; Name=A; IsoId=Q12809-1; Sequence=Displayed; Name=B; IsoId=Q12809-2; Sequence=VSP_000965; Name=4; IsoId=Q12809-4; Sequence=VSP_000966; Note=No experimental confirmation available.; Name=A-USO; IsoId=Q12809-5; Sequence=VSP_047880, VSP_047881; Note=Twice more abundant than isoform 1 in heart.; Name=B-USO; IsoId=Q12809-6; Sequence=VSP_047878, VSP_047879, VSP_047880, VSP_047881; Name=3.1; IsoId=Q12809-7; Sequence=VSP_047877; Note=Primate-specific. Lacks a domain that is crucial for slow channel deactivation.; 
# AltName	KCNH2_HUMAN	Eag homolog
# AltName	KCNH2_HUMAN	Ether-a-go-go-related gene potassium channel 1
# AltName	KCNH2_HUMAN	Voltage-gated potassium channel subunit Kv11.1
# BioGrid	109959	21
# CCDS	CCDS5910	-. [Q12809-1]
# CCDS	CCDS5911	-. [Q12809-2]
# ChiTaRS	KCNH2	human
# DISEASE	KCNH2_HUMAN	Long QT syndrome 2 (LQT2) [MIM 613688]  A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. Deafness is often associated with long QT syndrome type 2. {ECO 0000269|PubMed 10086971, ECO 0000269|PubMed 10187793, ECO 0000269|PubMed 10220144, ECO 0000269|PubMed 10517660, ECO 0000269|PubMed 10735633, ECO 0000269|PubMed 10862094, ECO 0000269|PubMed 10973849, ECO 0000269|PubMed 11170080, ECO 0000269|PubMed 12062363, ECO 0000269|PubMed 12354768, ECO 0000269|PubMed 12442276, ECO 0000269|PubMed 12621127, ECO 0000269|PubMed 15051636, ECO 0000269|PubMed 15840476, ECO 0000269|PubMed 16414944, ECO 0000269|PubMed 16922724, ECO 0000269|PubMed 19716085, ECO 0000269|PubMed 22314138, ECO 0000269|PubMed 7889573, ECO 0000269|PubMed 8635257, ECO 0000269|PubMed 8877771, ECO 0000269|PubMed 8914737, ECO 0000269|PubMed 9024139, ECO 0000269|PubMed 9452080, ECO 0000269|PubMed 9544837, ECO 0000269|PubMed 9600240, ECO 0000269|PubMed 9693036}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	KCNH2_HUMAN	Short QT syndrome 1 (SQT1) [MIM 609620]  A heart disorder characterized by idiopathic persistently and uniformly short QT interval on ECG in the absence of structural heart disease in affected individuals. It causes syncope and sudden death. {ECO 0000269|PubMed 14676148, ECO 0000269|PubMed 15828882}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	KCNH2_HUMAN	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. 
# DrugBank	DB00199	Erythromycin
# DrugBank	DB00204	Dofetilide
# DrugBank	DB00276	Amsacrine
# DrugBank	DB00308	Ibutilide
# DrugBank	DB00346	Alfuzosin
# DrugBank	DB00457	Prazosin
# DrugBank	DB00458	Imipramine
# DrugBank	DB00477	Chlorpromazine
# DrugBank	DB00489	Sotalol
# DrugBank	DB00537	Ciprofloxacin
# DrugBank	DB00590	Doxazosin
# DrugBank	DB00604	Cisapride
# DrugBank	DB00637	Astemizole
# DrugBank	DB00661	Verapamil
# DrugBank	DB00679	Thioridazine
# DrugBank	DB00908	Quinidine
# DrugBank	DB01100	Pimozide
# DrugBank	DB01110	Miconazole
# DrugBank	DB01118	Amiodarone
# DrugBank	DB01136	Carvedilol
# DrugBank	DB01142	Doxepin
# DrugBank	DB01162	Terazosin
# DrugBank	DB01182	Propafenone
# DrugBank	DB01211	Clarithromycin
# DrugBank	DB01218	Halofantrine
# DrugBank	DB04855	Dronedarone
# DrugBank	DB06144	Sertindole
# Ensembl	ENST00000262186	ENSP00000262186; ENSG00000055118. [Q12809-1]
# Ensembl	ENST00000330883	ENSP00000328531; ENSG00000055118. [Q12809-2]
# ExpressionAtlas	Q12809	baseline and differential
# FUNCTION	KCNH2_HUMAN	Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoforms USO have no channel activity by themself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation. {ECO 0000269|PubMed 18559421}. 
# GO_component	GO:0005886	plasma membrane; IDA:BHF-UCL.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IDA:BHF-UCL.
# GO_component	GO:0009986	cell surface; IDA:BHF-UCL.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IMP:BHF-UCL.
# GO_function	GO:0000155	phosphorelay sensor kinase activity; IEA:InterPro.
# GO_function	GO:0005242	inward rectifier potassium channel activity; IDA:BHF-UCL.
# GO_function	GO:0005249	voltage-gated potassium channel activity; IDA:BHF-UCL.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; IDA:BHF-UCL.
# GO_function	GO:0031625	ubiquitin protein ligase binding; IPI:BHF-UCL.
# GO_function	GO:0042802	identical protein binding; IPI:IntAct.
# GO_function	GO:0042803	protein homodimerization activity; IPI:BHF-UCL.
# GO_function	GO:0055131	C3HC4-type RING finger domain binding; IPI:BHF-UCL.
# GO_function	GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization; IC:BHF-UCL.
# GO_function	GO:0097110	scaffold protein binding; IPI:BHF-UCL.
# GO_function	GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization; IMP:BHF-UCL.
# GO_process	GO:0003064	regulation of heart rate by hormone; TAS:BHF-UCL.
# GO_process	GO:0035690	cellular response to drug; IDA:BHF-UCL.
# GO_process	GO:0042391	regulation of membrane potential; IDA:BHF-UCL.
# GO_process	GO:0055075	potassium ion homeostasis; IDA:BHF-UCL.
# GO_process	GO:0060048	cardiac muscle contraction; IMP:BHF-UCL.
# GO_process	GO:0060306	regulation of membrane repolarization; IDA:BHF-UCL.
# GO_process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization; IMP:BHF-UCL.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:0071435	potassium ion export; IDA:BHF-UCL.
# GO_process	GO:0071805	potassium ion transmembrane transport; IDA:BHF-UCL.
# GO_process	GO:0086005	ventricular cardiac muscle cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086010	membrane depolarization during action potential; IDA:BHF-UCL.
# GO_process	GO:0086011	membrane repolarization during action potential; IDA:BHF-UCL.
# GO_process	GO:0086013	membrane repolarization during cardiac muscle cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086091	regulation of heart rate by cardiac conduction; IMP:BHF-UCL.
# GO_process	GO:0097623	potassium ion export across plasma membrane; IGI:BHF-UCL.
# GO_process	GO:0098915	membrane repolarization during ventricular cardiac muscle cell action potential; IMP:BHF-UCL.
# GO_process	GO:1901379	regulation of potassium ion transmembrane transport; IDA:BHF-UCL.
# GO_process	GO:1901380	negative regulation of potassium ion transmembrane transport; IDA:BHF-UCL.
# GO_process	GO:1901381	positive regulation of potassium ion transmembrane transport; IDA:BHF-UCL.
# GO_process	GO:1902303	negative regulation of potassium ion export; IDA:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0016301	kinase activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.120.10	-; 2.
# Genevisible	Q12809	HS
# HGNC	HGNC:6251	KCNH2
# INDUCTION	Up-regulated by RNF207 (at protein level). {ECO:0000269|PubMed	25281747}. 
# INTERACTION	KCNH2_HUMAN	Self; NbExp=6; IntAct=EBI-720643, EBI-720643; Q03135 CAV1; NbExp=5; IntAct=EBI-720643, EBI-603614; 
# IntAct	Q12809	7
# InterPro	IPR000014	PAS
# InterPro	IPR000595	cNMP-bd_dom
# InterPro	IPR000700	PAS-assoc_C
# InterPro	IPR001610	PAC
# InterPro	IPR003938	K_chnl_volt-dep_EAG/ELK/ERG
# InterPro	IPR003967	K_chnl_volt-dep_ERG
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR014710	RmlC-like_jellyroll
# InterPro	IPR018490	cNMP-bd-like
# KEGG_Brite	ko04040	Ion channels
# KEGG_Disease	H00720	[Cardiovascular disease] Jervell and Lange-Nielsen syndrome (JLNS)
# KEGG_Disease	H00725	[Cardiovascular disease] Short QT syndrome
# MIM	152427	gene
# MIM	609620	phenotype
# MIM	613688	phenotype
# Organism	KCNH2_HUMAN	Homo sapiens (Human)
# Orphanet	101016	Romano-Ward syndrome
# Orphanet	51083	Familial short QT syndrome
# PDB	1BYW	X-ray; 2.60 A; A=26-135
# PDB	1UJL	NMR; -; A=570-611
# PDB	2L0W	NMR; -; A=1-135
# PDB	2L1M	NMR; -; A=1-135
# PDB	2L4R	NMR; -; A=1-135
# PDB	2LE7	NMR; -; A=532-551
# PDB	2N7G	NMR; -; A=734-864
# PDB	4HP9	X-ray; 2.12 A; A=10-135
# PDB	4HQA	X-ray; 1.96 A; A=1-135
# PIR	I38465	I38465
# PRINTS	PR01463	EAGCHANLFMLY
# PRINTS	PR01470	ERGCHANNEL
# PROSITE	PS50042	CNMP_BINDING_3
# PROSITE	PS50112	PAS
# PROSITE	PS50113	PAC
# PTM	KCNH2_HUMAN	Phosphorylated on serine and threonine residues. Phosphorylation by PKA inhibits ion conduction. {ECO 0000269|PubMed 10837251}. 
# Pfam	PF00027	cNMP_binding
# Pfam	PF00520	Ion_trans
# Pfam	PF13426	PAS_9
# Proteomes	UP000005640	Chromosome 7
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# Reactome	R-HSA-5576890	Phase 3 - rapid repolarisation
# RecName	KCNH2_HUMAN	Potassium voltage-gated channel subfamily H member 2
# RefSeq	NP_000229	NM_000238.3. [Q12809-1]
# RefSeq	NP_001191727	NM_001204798.1. [Q12809-6]
# RefSeq	NP_742053	NM_172056.2. [Q12809-5]
# RefSeq	NP_742054	NM_172057.2. [Q12809-2]
# SEQUENCE CAUTION	Sequence=CAA09232.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 1 PAC (PAS-associated C-terminal) domain. {ECO:0000255|PROSITE-ProRule	PRU00141}. 
# SIMILARITY	Contains 1 PAS (PER-ARNT-SIM) domain. {ECO:0000255|PROSITE-ProRule	PRU00140}. 
# SIMILARITY	Contains 1 cyclic nucleotide-binding domain. {ECO:0000255|PROSITE-ProRule	PRU00060}. 
# SMART	SM00086	PAC
# SMART	SM00100	cNMP
# SUBCELLULAR LOCATION	KCNH2_HUMAN	Cell membrane {ECO 0000269|PubMed 18559421, ECO 0000269|PubMed 19412172}; Multi-pass membrane protein {ECO 0000269|PubMed 18559421, ECO 0000269|PubMed 19412172}. 
# SUBUNIT	KCNH2_HUMAN	The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH6/ERG2 and KCNH7/ERG3 (By similarity). Interacts with ALG10B (By similarity). Heteromultimer with KCNE1 and KCNE2 (PubMed 9230439, PubMed 10219239). Interacts with CANX (PubMed 16361248). The core-glycosylated, but not the fully glycosylated form interacts with RNF207 (PubMed 25281747). {ECO 0000250|UniProtKB O08962, ECO 0000269|PubMed 10219239, ECO 0000269|PubMed 16361248, ECO 0000269|PubMed 25281747, ECO 0000269|PubMed 9230439}. 
# SUPFAM	SSF51206	SSF51206
# SUPFAM	SSF55785	SSF55785
# TCDB	1.A.1.20	the voltage-gated ion channel (vic) superfamily
# TIGRFAMs	TIGR00229	sensory_box
# TISSUE SPECIFICITY	Highly expressed in heart and brain. Isoforms USO are frequently overexpressed in cancer cells. {ECO:0000269|PubMed	18559421}. 
# UCSC	uc003wib	human. [Q12809-1]
# WEB RESOURCE	KCNH2_HUMAN	Name=Wikipedia; Note=Ether-a-go-go potassium channels entry; URL="https //en.wikipedia.org/wiki/Ether-a-go-go_potassium_channels";
# eggNOG	ENOG410XPSE	LUCA
# eggNOG	KOG0498	Eukaryota
BLAST	swissprot:KCNH2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNH2_HUMAN
BioCyc	ZFISH:ENSG00000055118-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000055118-MONOMER
COXPRESdb	3757	http://coxpresdb.jp/data/gene/3757.shtml
CleanEx	HS_ERG	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ERG
CleanEx	HS_KCNH2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNH2
DIP	DIP-48929N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48929N
DOI	10.1001/jama.294.23.2975	http://dx.doi.org/10.1001/jama.294.23.2975
DOI	10.1002/(SICI)1096-8628(19961002)65:1<27::AID-AJMG4>3.3.CO	http://dx.doi.org/10.1002/(SICI)1096-8628(19961002)65:1<27::AID-AJMG4>3.3.CO
DOI	10.1002/(SICI)1098-1004(1999)13:4<301::AID-HUMU7>3.0.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(1999)13:4<301::AID-HUMU7>3.0.CO
DOI	10.1002/(SICI)1098-1004(200005)15:5<483::AID-HUMU18>3.3.CO	http://dx.doi.org/10.1002/(SICI)1098-1004(200005)15:5<483::AID-HUMU18>3.3.CO
DOI	10.1002/1096-8628(20010201)98:4<348::AID-AJMG1109>3.0.CO	http://dx.doi.org/10.1002/1096-8628(20010201)98:4<348::AID-AJMG1109>3.0.CO
DOI	10.1002/1098-1004(200006)15:6<580::AID-HUMU16>3.3.CO	http://dx.doi.org/10.1002/1098-1004(200006)15:6<580::AID-HUMU16>3.3.CO
DOI	10.1002/humu.9085	http://dx.doi.org/10.1002/humu.9085
DOI	10.1006/geno.1998.5361	http://dx.doi.org/10.1006/geno.1998.5361
DOI	10.1006/geno.2001.6527	http://dx.doi.org/10.1006/geno.2001.6527
DOI	10.1006/jmcc.1996.0151	http://dx.doi.org/10.1006/jmcc.1996.0151
DOI	10.1007/s004390050690	http://dx.doi.org/10.1007/s004390050690
DOI	10.1007/s004390050717	http://dx.doi.org/10.1007/s004390050717
DOI	10.1016/0092-8674(95)90358-5	http://dx.doi.org/10.1016/0092-8674(95)90358-5
DOI	10.1016/S0008-6363(02)00240-7	http://dx.doi.org/10.1016/S0008-6363(02)00240-7
DOI	10.1016/S0092-8674(00)80728-X	http://dx.doi.org/10.1016/S0092-8674(00)80728-X
DOI	10.1016/S0092-8674(00)81635-9	http://dx.doi.org/10.1016/S0092-8674(00)81635-9
DOI	10.1016/S0960-9822(00)00516-9	http://dx.doi.org/10.1016/S0960-9822(00)00516-9
DOI	10.1016/j.bbrc.2012.01.118	http://dx.doi.org/10.1016/j.bbrc.2012.01.118
DOI	10.1016/j.hrthm.2005.01.020	http://dx.doi.org/10.1016/j.hrthm.2005.01.020
DOI	10.1016/j.hrthm.2009.05.021	http://dx.doi.org/10.1016/j.hrthm.2009.05.021
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1034/j.1399-0004.2000.570206.x	http://dx.doi.org/10.1034/j.1399-0004.2000.570206.x
DOI	10.1038/40882	http://dx.doi.org/10.1038/40882
DOI	10.1038/nature01782	http://dx.doi.org/10.1038/nature01782
DOI	10.1038/nm.1962	http://dx.doi.org/10.1038/nm.1962
DOI	10.1046/j.1540-8167.2005.40621.x	http://dx.doi.org/10.1046/j.1540-8167.2005.40621.x
DOI	10.1073/pnas.91.8.3438	http://dx.doi.org/10.1073/pnas.91.8.3438
DOI	10.1074/jbc.273.42.27231	http://dx.doi.org/10.1074/jbc.273.42.27231
DOI	10.1074/jbc.274.15.10113	http://dx.doi.org/10.1074/jbc.274.15.10113
DOI	10.1074/jbc.275.15.11241	http://dx.doi.org/10.1074/jbc.275.15.11241
DOI	10.1074/jbc.M114.592295	http://dx.doi.org/10.1074/jbc.M114.592295
DOI	10.1074/jbc.M206569200	http://dx.doi.org/10.1074/jbc.M206569200
DOI	10.1074/jbc.M210789200	http://dx.doi.org/10.1074/jbc.M210789200
DOI	10.1074/jbc.M511765200	http://dx.doi.org/10.1074/jbc.M511765200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1399-0004.2006.00671.x	http://dx.doi.org/10.1111/j.1399-0004.2006.00671.x
DOI	10.1111/j.1540-8167.1999.tb00304.x	http://dx.doi.org/10.1111/j.1540-8167.1999.tb00304.x
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1128/MCB.00304-08	http://dx.doi.org/10.1128/MCB.00304-08
DOI	10.1152/ajpheart.00008.2002	http://dx.doi.org/10.1152/ajpheart.00008.2002
DOI	10.1161/01.CIR.0000014448.19052.4C	http://dx.doi.org/10.1161/01.CIR.0000014448.19052.4C
DOI	10.1161/01.CIR.0000109482.92774.3A	http://dx.doi.org/10.1161/01.CIR.0000109482.92774.3A
DOI	10.1161/01.CIR.0000125524.34234.13	http://dx.doi.org/10.1161/01.CIR.0000125524.34234.13
DOI	10.1161/01.CIR.102.10.1178	http://dx.doi.org/10.1161/01.CIR.102.10.1178
DOI	10.1161/01.CIR.93.10.1791	http://dx.doi.org/10.1161/01.CIR.93.10.1791
DOI	10.1161/01.CIR.95.3.565	http://dx.doi.org/10.1161/01.CIR.95.3.565
DOI	10.1161/01.CIR.99.11.1464	http://dx.doi.org/10.1161/01.CIR.99.11.1464
DOI	10.1161/01.RES.81.5.719	http://dx.doi.org/10.1161/01.RES.81.5.719
DOI	10.1161/01.RES.81.5.870	http://dx.doi.org/10.1161/01.RES.81.5.870
DOI	10.1203/01.PDR.0000059750.17002.B6	http://dx.doi.org/10.1203/01.PDR.0000059750.17002.B6
DrugBank	DB00199	http://www.drugbank.ca/drugs/DB00199
DrugBank	DB00204	http://www.drugbank.ca/drugs/DB00204
DrugBank	DB00276	http://www.drugbank.ca/drugs/DB00276
DrugBank	DB00308	http://www.drugbank.ca/drugs/DB00308
DrugBank	DB00346	http://www.drugbank.ca/drugs/DB00346
DrugBank	DB00457	http://www.drugbank.ca/drugs/DB00457
DrugBank	DB00458	http://www.drugbank.ca/drugs/DB00458
DrugBank	DB00477	http://www.drugbank.ca/drugs/DB00477
DrugBank	DB00489	http://www.drugbank.ca/drugs/DB00489
DrugBank	DB00537	http://www.drugbank.ca/drugs/DB00537
DrugBank	DB00590	http://www.drugbank.ca/drugs/DB00590
DrugBank	DB00604	http://www.drugbank.ca/drugs/DB00604
DrugBank	DB00637	http://www.drugbank.ca/drugs/DB00637
DrugBank	DB00661	http://www.drugbank.ca/drugs/DB00661
DrugBank	DB00679	http://www.drugbank.ca/drugs/DB00679
DrugBank	DB00908	http://www.drugbank.ca/drugs/DB00908
DrugBank	DB01100	http://www.drugbank.ca/drugs/DB01100
DrugBank	DB01110	http://www.drugbank.ca/drugs/DB01110
DrugBank	DB01118	http://www.drugbank.ca/drugs/DB01118
DrugBank	DB01136	http://www.drugbank.ca/drugs/DB01136
DrugBank	DB01142	http://www.drugbank.ca/drugs/DB01142
DrugBank	DB01162	http://www.drugbank.ca/drugs/DB01162
DrugBank	DB01182	http://www.drugbank.ca/drugs/DB01182
DrugBank	DB01211	http://www.drugbank.ca/drugs/DB01211
DrugBank	DB01218	http://www.drugbank.ca/drugs/DB01218
DrugBank	DB04855	http://www.drugbank.ca/drugs/DB04855
DrugBank	DB06144	http://www.drugbank.ca/drugs/DB06144
EMBL	AB009071	http://www.ebi.ac.uk/ena/data/view/AB009071
EMBL	AB044806	http://www.ebi.ac.uk/ena/data/view/AB044806
EMBL	AC006343	http://www.ebi.ac.uk/ena/data/view/AC006343
EMBL	AC011234	http://www.ebi.ac.uk/ena/data/view/AC011234
EMBL	AF052728	http://www.ebi.ac.uk/ena/data/view/AF052728
EMBL	AF363636	http://www.ebi.ac.uk/ena/data/view/AF363636
EMBL	AJ010538	http://www.ebi.ac.uk/ena/data/view/AJ010538
EMBL	AJ010539	http://www.ebi.ac.uk/ena/data/view/AJ010539
EMBL	AJ010540	http://www.ebi.ac.uk/ena/data/view/AJ010540
EMBL	AJ010541	http://www.ebi.ac.uk/ena/data/view/AJ010541
EMBL	AJ010542	http://www.ebi.ac.uk/ena/data/view/AJ010542
EMBL	AJ010543	http://www.ebi.ac.uk/ena/data/view/AJ010543
EMBL	AJ010544	http://www.ebi.ac.uk/ena/data/view/AJ010544
EMBL	AJ010545	http://www.ebi.ac.uk/ena/data/view/AJ010545
EMBL	AJ010546	http://www.ebi.ac.uk/ena/data/view/AJ010546
EMBL	AJ010547	http://www.ebi.ac.uk/ena/data/view/AJ010547
EMBL	AJ010548	http://www.ebi.ac.uk/ena/data/view/AJ010548
EMBL	AJ010549	http://www.ebi.ac.uk/ena/data/view/AJ010549
EMBL	AJ010550	http://www.ebi.ac.uk/ena/data/view/AJ010550
EMBL	AJ010551	http://www.ebi.ac.uk/ena/data/view/AJ010551
EMBL	AJ512214	http://www.ebi.ac.uk/ena/data/view/AJ512214
EMBL	AJ609614	http://www.ebi.ac.uk/ena/data/view/AJ609614
EMBL	BC001914	http://www.ebi.ac.uk/ena/data/view/BC001914
EMBL	BC004311	http://www.ebi.ac.uk/ena/data/view/BC004311
EMBL	CH471173	http://www.ebi.ac.uk/ena/data/view/CH471173
EMBL	CH471173	http://www.ebi.ac.uk/ena/data/view/CH471173
EMBL	DQ784808	http://www.ebi.ac.uk/ena/data/view/DQ784808
EMBL	FJ938021	http://www.ebi.ac.uk/ena/data/view/FJ938021
EMBL	U04270	http://www.ebi.ac.uk/ena/data/view/U04270
Ensembl	ENST00000262186	http://www.ensembl.org/id/ENST00000262186
Ensembl	ENST00000330883	http://www.ensembl.org/id/ENST00000330883
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_function	GO:0000155	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155
GO_function	GO:0005242	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005242
GO_function	GO:0005249	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005249
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_function	GO:0031625	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031625
GO_function	GO:0042802	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_function	GO:0055131	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055131
GO_function	GO:0086008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086008
GO_function	GO:0097110	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097110
GO_function	GO:1902282	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902282
GO_process	GO:0003064	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003064
GO_process	GO:0035690	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035690
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0055075	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055075
GO_process	GO:0060048	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060048
GO_process	GO:0060306	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060306
GO_process	GO:0060307	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060307
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:0071435	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071435
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GO_process	GO:0086005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086005
GO_process	GO:0086010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086010
GO_process	GO:0086011	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086011
GO_process	GO:0086013	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086013
GO_process	GO:0086091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086091
GO_process	GO:0097623	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097623
GO_process	GO:0098915	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098915
GO_process	GO:1901379	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901379
GO_process	GO:1901380	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901380
GO_process	GO:1901381	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901381
GO_process	GO:1902303	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902303
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0016301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.120.10	http://www.cathdb.info/version/latest/superfamily/2.60.120.10
GeneCards	KCNH2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNH2
GeneID	3757	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3757
GeneTree	ENSGT00760000118772	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118772
HGNC	HGNC:6251	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6251
HOGENOM	HOG000207541	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000207541&db=HOGENOM6
HOVERGEN	HBG052232	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052232&db=HOVERGEN
HPA	CAB006838	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB006838
HPA	HPA040783	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA040783
HPA	HPA056584	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA056584
InParanoid	Q12809	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q12809
IntAct	Q12809	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q12809*
InterPro	IPR000014	http://www.ebi.ac.uk/interpro/entry/IPR000014
InterPro	IPR000595	http://www.ebi.ac.uk/interpro/entry/IPR000595
InterPro	IPR000700	http://www.ebi.ac.uk/interpro/entry/IPR000700
InterPro	IPR001610	http://www.ebi.ac.uk/interpro/entry/IPR001610
InterPro	IPR003938	http://www.ebi.ac.uk/interpro/entry/IPR003938
InterPro	IPR003967	http://www.ebi.ac.uk/interpro/entry/IPR003967
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR014710	http://www.ebi.ac.uk/interpro/entry/IPR014710
InterPro	IPR018490	http://www.ebi.ac.uk/interpro/entry/IPR018490
Jabion	3757	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3757
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00720	http://www.genome.jp/dbget-bin/www_bget?H00720
KEGG_Disease	H00725	http://www.genome.jp/dbget-bin/www_bget?H00725
KEGG_Gene	hsa:3757	http://www.genome.jp/dbget-bin/www_bget?hsa:3757
KEGG_Orthology	KO:K04905	http://www.genome.jp/dbget-bin/www_bget?KO:K04905
MIM	152427	http://www.ncbi.nlm.nih.gov/omim/152427
MIM	609620	http://www.ncbi.nlm.nih.gov/omim/609620
MIM	613688	http://www.ncbi.nlm.nih.gov/omim/613688
MINT	MINT-1427435	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1427435
OMA	FMAFEEL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FMAFEEL
Orphanet	101016	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=101016
Orphanet	51083	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=51083
OrthoDB	EOG091G024C	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G024C
PDB	1BYW	http://www.ebi.ac.uk/pdbe-srv/view/entry/1BYW
PDB	1UJL	http://www.ebi.ac.uk/pdbe-srv/view/entry/1UJL
PDB	2L0W	http://www.ebi.ac.uk/pdbe-srv/view/entry/2L0W
PDB	2L1M	http://www.ebi.ac.uk/pdbe-srv/view/entry/2L1M
PDB	2L4R	http://www.ebi.ac.uk/pdbe-srv/view/entry/2L4R
PDB	2LE7	http://www.ebi.ac.uk/pdbe-srv/view/entry/2LE7
PDB	2N7G	http://www.ebi.ac.uk/pdbe-srv/view/entry/2N7G
PDB	4HP9	http://www.ebi.ac.uk/pdbe-srv/view/entry/4HP9
PDB	4HQA	http://www.ebi.ac.uk/pdbe-srv/view/entry/4HQA
PDBsum	1BYW	http://www.ebi.ac.uk/pdbsum/1BYW
PDBsum	1UJL	http://www.ebi.ac.uk/pdbsum/1UJL
PDBsum	2L0W	http://www.ebi.ac.uk/pdbsum/2L0W
PDBsum	2L1M	http://www.ebi.ac.uk/pdbsum/2L1M
PDBsum	2L4R	http://www.ebi.ac.uk/pdbsum/2L4R
PDBsum	2LE7	http://www.ebi.ac.uk/pdbsum/2LE7
PDBsum	2N7G	http://www.ebi.ac.uk/pdbsum/2N7G
PDBsum	4HP9	http://www.ebi.ac.uk/pdbsum/4HP9
PDBsum	4HQA	http://www.ebi.ac.uk/pdbsum/4HQA
PRINTS	PR01463	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01463
PRINTS	PR01470	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01470
PROSITE	PS50042	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50042
PROSITE	PS50112	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50112
PROSITE	PS50113	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50113
PSORT	swissprot:KCNH2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNH2_HUMAN
PSORT-B	swissprot:KCNH2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNH2_HUMAN
PSORT2	swissprot:KCNH2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNH2_HUMAN
Pfam	PF00027	http://pfam.xfam.org/family/PF00027
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF13426	http://pfam.xfam.org/family/PF13426
PharmGKB	PA212	http://www.pharmgkb.org/do/serve?objId=PA212&objCls=Gene
Phobius	swissprot:KCNH2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNH2_HUMAN
PhylomeDB	Q12809	http://phylomedb.org/?seqid=Q12809
ProteinModelPortal	Q12809	http://www.proteinmodelportal.org/query/uniprot/Q12809
PubMed	10086971	http://www.ncbi.nlm.nih.gov/pubmed/10086971
PubMed	10187793	http://www.ncbi.nlm.nih.gov/pubmed/10187793
PubMed	10219239	http://www.ncbi.nlm.nih.gov/pubmed/10219239
PubMed	10220144	http://www.ncbi.nlm.nih.gov/pubmed/10220144
PubMed	10517660	http://www.ncbi.nlm.nih.gov/pubmed/10517660
PubMed	10735633	http://www.ncbi.nlm.nih.gov/pubmed/10735633
PubMed	10753933	http://www.ncbi.nlm.nih.gov/pubmed/10753933
PubMed	10790218	http://www.ncbi.nlm.nih.gov/pubmed/10790218
PubMed	10837251	http://www.ncbi.nlm.nih.gov/pubmed/10837251
PubMed	10862094	http://www.ncbi.nlm.nih.gov/pubmed/10862094
PubMed	10973849	http://www.ncbi.nlm.nih.gov/pubmed/10973849
PubMed	11170080	http://www.ncbi.nlm.nih.gov/pubmed/11170080
PubMed	11374908	http://www.ncbi.nlm.nih.gov/pubmed/11374908
PubMed	11997281	http://www.ncbi.nlm.nih.gov/pubmed/11997281
PubMed	12062363	http://www.ncbi.nlm.nih.gov/pubmed/12062363
PubMed	12063277	http://www.ncbi.nlm.nih.gov/pubmed/12063277
PubMed	12354768	http://www.ncbi.nlm.nih.gov/pubmed/12354768
PubMed	12431979	http://www.ncbi.nlm.nih.gov/pubmed/12431979
PubMed	12442276	http://www.ncbi.nlm.nih.gov/pubmed/12442276
PubMed	12621127	http://www.ncbi.nlm.nih.gov/pubmed/12621127
PubMed	12853948	http://www.ncbi.nlm.nih.gov/pubmed/12853948
PubMed	14676148	http://www.ncbi.nlm.nih.gov/pubmed/14676148
PubMed	15051636	http://www.ncbi.nlm.nih.gov/pubmed/15051636
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15828882	http://www.ncbi.nlm.nih.gov/pubmed/15828882
PubMed	15840476	http://www.ncbi.nlm.nih.gov/pubmed/15840476
PubMed	16361248	http://www.ncbi.nlm.nih.gov/pubmed/16361248
PubMed	16414944	http://www.ncbi.nlm.nih.gov/pubmed/16414944
PubMed	16922724	http://www.ncbi.nlm.nih.gov/pubmed/16922724
PubMed	18559421	http://www.ncbi.nlm.nih.gov/pubmed/18559421
PubMed	19412172	http://www.ncbi.nlm.nih.gov/pubmed/19412172
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	19716085	http://www.ncbi.nlm.nih.gov/pubmed/19716085
PubMed	22314138	http://www.ncbi.nlm.nih.gov/pubmed/22314138
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	25281747	http://www.ncbi.nlm.nih.gov/pubmed/25281747
PubMed	7889573	http://www.ncbi.nlm.nih.gov/pubmed/7889573
PubMed	8159766	http://www.ncbi.nlm.nih.gov/pubmed/8159766
PubMed	8635257	http://www.ncbi.nlm.nih.gov/pubmed/8635257
PubMed	8877771	http://www.ncbi.nlm.nih.gov/pubmed/8877771
PubMed	8914737	http://www.ncbi.nlm.nih.gov/pubmed/8914737
PubMed	9024139	http://www.ncbi.nlm.nih.gov/pubmed/9024139
PubMed	9230439	http://www.ncbi.nlm.nih.gov/pubmed/9230439
PubMed	9351446	http://www.ncbi.nlm.nih.gov/pubmed/9351446
PubMed	9351462	http://www.ncbi.nlm.nih.gov/pubmed/9351462
PubMed	9452080	http://www.ncbi.nlm.nih.gov/pubmed/9452080
PubMed	9544837	http://www.ncbi.nlm.nih.gov/pubmed/9544837
PubMed	9600240	http://www.ncbi.nlm.nih.gov/pubmed/9600240
PubMed	9693036	http://www.ncbi.nlm.nih.gov/pubmed/9693036
PubMed	9765245	http://www.ncbi.nlm.nih.gov/pubmed/9765245
PubMed	9845367	http://www.ncbi.nlm.nih.gov/pubmed/9845367
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
Reactome	R-HSA-5576890	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576890
RefSeq	NP_000229	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000229
RefSeq	NP_001191727	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001191727
RefSeq	NP_742053	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_742053
RefSeq	NP_742054	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_742054
SMART	SM00086	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00086
SMART	SM00100	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00100
SMR	Q12809	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q12809
STRING	9606.ENSP00000262186	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000262186&targetmode=cogs
SUPFAM	SSF51206	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51206
SUPFAM	SSF55785	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55785
TCDB	1.A.1.20	http://www.tcdb.org/search/result.php?tc=1.A.1.20
TIGRFAMs	TIGR00229	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00229
UCSC	uc003wib	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003wib&org=rat
UniGene	Hs.647099	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.647099
UniProtKB	KCNH2_HUMAN	http://www.uniprot.org/uniprot/KCNH2_HUMAN
UniProtKB-AC	Q12809	http://www.uniprot.org/uniprot/Q12809
charge	swissprot:KCNH2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNH2_HUMAN
eggNOG	ENOG410XPSE	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPSE
eggNOG	KOG0498	http://eggnogapi.embl.de/nog_data/html/tree/KOG0498
epestfind	swissprot:KCNH2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNH2_HUMAN
garnier	swissprot:KCNH2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNH2_HUMAN
helixturnhelix	swissprot:KCNH2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNH2_HUMAN
hmoment	swissprot:KCNH2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNH2_HUMAN
iep	swissprot:KCNH2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNH2_HUMAN
inforesidue	swissprot:KCNH2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNH2_HUMAN
neXtProt	NX_Q12809	http://www.nextprot.org/db/entry/NX_Q12809
octanol	swissprot:KCNH2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNH2_HUMAN
pepcoil	swissprot:KCNH2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNH2_HUMAN
pepdigest	swissprot:KCNH2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNH2_HUMAN
pepinfo	swissprot:KCNH2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNH2_HUMAN
pepnet	swissprot:KCNH2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNH2_HUMAN
pepstats	swissprot:KCNH2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNH2_HUMAN
pepwheel	swissprot:KCNH2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNH2_HUMAN
pepwindow	swissprot:KCNH2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNH2_HUMAN
sigcleave	swissprot:KCNH2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNH2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S12A2_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P55011-1; Sequence=Displayed; Name=2; IsoId=P55011-3; Sequence=VSP_006105; 
# AltName	S12A2_HUMAN	Basolateral Na-K-Cl symporter
# AltName	S12A2_HUMAN	Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1
# BioGrid	112447	31
# CCDS	CCDS4144	-. [P55011-1]
# CCDS	CCDS58965	-. [P55011-3]
# ChiTaRS	SLC12A2	human
# DrugBank	DB00761	Potassium Chloride
# DrugBank	DB00887	Bumetanide
# DrugBank	DB01325	Quinethazone
# ENZYME REGULATION	Activated by WNK3. {ECO:0000269|PubMed	21613606}. 
# Ensembl	ENST00000262461	ENSP00000262461; ENSG00000064651. [P55011-1]
# Ensembl	ENST00000343225	ENSP00000340878; ENSG00000064651. [P55011-3]
# ExpressionAtlas	P55011	baseline and differential
# FUNCTION	S12A2_HUMAN	Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0016324	apical plasma membrane; IBA:GO_Central.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_component	GO:1903561	extracellular vesicle; IDA:UniProtKB.
# GO_function	GO:0008519	ammonium transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0019901	protein kinase binding; IPI:ParkinsonsUK-UCL.
# GO_function	S12A2_HUMAN	GO 0008511 sodium potassium chloride symporter activity; TAS Reactome.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006813	potassium ion transport; IEA:UniProtKB-KW.
# GO_process	GO:0006814	sodium ion transport; IEA:UniProtKB-KW.
# GO_process	GO:0006972	hyperosmotic response; IEA:Ensembl.
# GO_process	GO:0007214	gamma-aminobutyric acid signaling pathway; IEA:Ensembl.
# GO_process	GO:0007568	aging; IEA:Ensembl.
# GO_process	GO:0015696	ammonium transport; IDA:UniProtKB.
# GO_process	GO:0030321	transepithelial chloride transport; IDA:UniProtKB.
# GO_process	GO:0045795	positive regulation of cell volume; IEA:Ensembl.
# GO_process	GO:0070634	transepithelial ammonium transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007568	aging
# GOslim_process	GO:0042592	homeostatic process
# Genevisible	P55011	HS
# HGNC	HGNC:10911	SLC12A2
# INTERACTION	S12A2_HUMAN	O95747 OXSR1; NbExp=2; IntAct=EBI-2801449, EBI-620853; 
# IntAct	P55011	14
# InterPro	IPR002443	Na/K/Cl_cotranspt
# InterPro	IPR002444	NKCC1
# InterPro	IPR004841	AA-permease/SLC12A_dom
# InterPro	IPR004842	SLC12A_fam
# InterPro	IPR013612	AA_permease_N
# InterPro	IPR018491	SLC12_C
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04970	Salivary secretion
# KEGG_Pathway	ko04972	Pancreatic secretion
# KEGG_Pathway	ko05110	Vibrio cholerae infection
# MIM	600840	gene
# Organism	S12A2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11827:SF58	PTHR11827:SF58; 3
# PIR	A57187	A57187
# PRINTS	PR01207	NAKCLTRNSPRT
# PRINTS	PR01208	NAKCLTRSPRT1
# Pfam	PF00324	AA_permease
# Pfam	PF03522	SLC12
# Pfam	PF08403	AA_permease_N
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-426117	Cation-coupled Chloride cotransporters
# RecName	S12A2_HUMAN	Solute carrier family 12 member 2
# RefSeq	NP_001037	NM_001046.2. [P55011-1]
# SIMILARITY	Belongs to the SLC12A transporter family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S12A2_HUMAN	Membrane; Multi-pass membrane protein. 
# TCDB	2.A.30.3	the cation-chloride cotransporter (ccc) family
# TIGRFAMs	TIGR00930	2a30
# TISSUE SPECIFICITY	S12A2_HUMAN	Expressed in many tissues. 
# UCSC	uc010jdg	human. [P55011-1]
# eggNOG	COG0531	LUCA
# eggNOG	KOG2083	Eukaryota
BLAST	swissprot:S12A2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S12A2_HUMAN
BioCyc	ZFISH:ENSG00000064651-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000064651-MONOMER
COXPRESdb	6558	http://coxpresdb.jp/data/gene/6558.shtml
CleanEx	HS_SLC12A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC12A2
DIP	DIP-43979N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-43979N
DOI	10.1006/abio.2001.5398	http://dx.doi.org/10.1006/abio.2001.5398
DOI	10.1021/pr0705441	http://dx.doi.org/10.1021/pr0705441
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/jbc.270.30.17977	http://dx.doi.org/10.1074/jbc.270.30.17977
DOI	10.1074/mcp.M111.015131	http://dx.doi.org/10.1074/mcp.M111.015131
DOI	10.1152/ajpcell.00070.2011	http://dx.doi.org/10.1152/ajpcell.00070.2011
DrugBank	DB00761	http://www.drugbank.ca/drugs/DB00761
DrugBank	DB00887	http://www.drugbank.ca/drugs/DB00887
DrugBank	DB01325	http://www.drugbank.ca/drugs/DB01325
EMBL	AF439152	http://www.ebi.ac.uk/ena/data/view/AF439152
EMBL	U30246	http://www.ebi.ac.uk/ena/data/view/U30246
Ensembl	ENST00000262461	http://www.ensembl.org/id/ENST00000262461
Ensembl	ENST00000343225	http://www.ensembl.org/id/ENST00000343225
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_component	GO:1903561	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903561
GO_function	GO:0008511	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008511
GO_function	GO:0008519	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008519
GO_function	GO:0019901	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019901
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0006972	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006972
GO_process	GO:0007214	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007214
GO_process	GO:0007568	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007568
GO_process	GO:0015696	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015696
GO_process	GO:0030321	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030321
GO_process	GO:0045795	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045795
GO_process	GO:0070634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070634
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007568	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007568
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GeneCards	SLC12A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC12A2
GeneID	6558	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6558
GeneTree	ENSGT00760000119053	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119053
HGNC	HGNC:10911	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10911
HOGENOM	HOG000062855	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000062855&db=HOGENOM6
HOVERGEN	HBG052851	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052851&db=HOVERGEN
HPA	HPA020130	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA020130
HPA	HPA063697	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA063697
InParanoid	P55011	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P55011
IntAct	P55011	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P55011*
InterPro	IPR002443	http://www.ebi.ac.uk/interpro/entry/IPR002443
InterPro	IPR002444	http://www.ebi.ac.uk/interpro/entry/IPR002444
InterPro	IPR004841	http://www.ebi.ac.uk/interpro/entry/IPR004841
InterPro	IPR004842	http://www.ebi.ac.uk/interpro/entry/IPR004842
InterPro	IPR013612	http://www.ebi.ac.uk/interpro/entry/IPR013612
InterPro	IPR018491	http://www.ebi.ac.uk/interpro/entry/IPR018491
Jabion	6558	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6558
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:6558	http://www.genome.jp/dbget-bin/www_bget?hsa:6558
KEGG_Orthology	KO:K10951	http://www.genome.jp/dbget-bin/www_bget?KO:K10951
KEGG_Pathway	ko04970	http://www.genome.jp/kegg-bin/show_pathway?ko04970
KEGG_Pathway	ko04972	http://www.genome.jp/kegg-bin/show_pathway?ko04972
KEGG_Pathway	ko05110	http://www.genome.jp/kegg-bin/show_pathway?ko05110
MIM	600840	http://www.ncbi.nlm.nih.gov/omim/600840
MINT	MINT-5004359	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5004359
OMA	LSMEYSK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LSMEYSK
OrthoDB	EOG091G04G2	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G04G2
PANTHER	PTHR11827:SF58	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11827:SF58
PRINTS	PR01207	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01207
PRINTS	PR01208	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01208
PSORT	swissprot:S12A2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S12A2_HUMAN
PSORT-B	swissprot:S12A2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S12A2_HUMAN
PSORT2	swissprot:S12A2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S12A2_HUMAN
Pfam	PF00324	http://pfam.xfam.org/family/PF00324
Pfam	PF03522	http://pfam.xfam.org/family/PF03522
Pfam	PF08403	http://pfam.xfam.org/family/PF08403
PharmGKB	PA35806	http://www.pharmgkb.org/do/serve?objId=PA35806&objCls=Gene
Phobius	swissprot:S12A2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S12A2_HUMAN
PhylomeDB	P55011	http://phylomedb.org/?seqid=P55011
ProteinModelPortal	P55011	http://www.proteinmodelportal.org/query/uniprot/P55011
PubMed	11700976	http://www.ncbi.nlm.nih.gov/pubmed/11700976
PubMed	18220336	http://www.ncbi.nlm.nih.gov/pubmed/18220336
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	21613606	http://www.ncbi.nlm.nih.gov/pubmed/21613606
PubMed	22223895	http://www.ncbi.nlm.nih.gov/pubmed/22223895
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	7629105	http://www.ncbi.nlm.nih.gov/pubmed/7629105
Reactome	R-HSA-426117	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-426117
RefSeq	NP_001037	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001037
STRING	9606.ENSP00000262461	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000262461&targetmode=cogs
TCDB	2.A.30.3	http://www.tcdb.org/search/result.php?tc=2.A.30.3
TIGRFAMs	TIGR00930	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00930
UCSC	uc010jdg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010jdg&org=rat
UniGene	Hs.162585	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.162585
UniGene	Hs.712970	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.712970
UniProtKB	S12A2_HUMAN	http://www.uniprot.org/uniprot/S12A2_HUMAN
UniProtKB-AC	P55011	http://www.uniprot.org/uniprot/P55011
charge	swissprot:S12A2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S12A2_HUMAN
eggNOG	COG0531	http://eggnogapi.embl.de/nog_data/html/tree/COG0531
eggNOG	KOG2083	http://eggnogapi.embl.de/nog_data/html/tree/KOG2083
epestfind	swissprot:S12A2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S12A2_HUMAN
garnier	swissprot:S12A2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S12A2_HUMAN
helixturnhelix	swissprot:S12A2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S12A2_HUMAN
hmoment	swissprot:S12A2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S12A2_HUMAN
iep	swissprot:S12A2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S12A2_HUMAN
inforesidue	swissprot:S12A2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S12A2_HUMAN
neXtProt	NX_P55011	http://www.nextprot.org/db/entry/NX_P55011
octanol	swissprot:S12A2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S12A2_HUMAN
pepcoil	swissprot:S12A2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S12A2_HUMAN
pepdigest	swissprot:S12A2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S12A2_HUMAN
pepinfo	swissprot:S12A2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S12A2_HUMAN
pepnet	swissprot:S12A2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S12A2_HUMAN
pepstats	swissprot:S12A2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S12A2_HUMAN
pepwheel	swissprot:S12A2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S12A2_HUMAN
pepwindow	swissprot:S12A2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S12A2_HUMAN
sigcleave	swissprot:S12A2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S12A2_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	125254	4
# ChiTaRS	MFSD3	human
# Ensembl	ENST00000301327	ENSP00000301327; ENSG00000167700
# GO_component	GO:0005789	endoplasmic reticulum membrane; IBA:GO_Central.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0008521	acetyl-CoA transporter activity; IBA:GO_Central.
# GO_function	MFSD3_HUMAN	GO 0015295 solute proton symporter activity; IBA GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# Genevisible	Q96ES6	HS
# HGNC	HGNC:25157	MFSD3
# IntAct	Q96ES6	5
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# Organism	MFSD3_HUMAN	Homo sapiens (Human)
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 8
# RecName	MFSD3_HUMAN	Major facilitator superfamily domain-containing protein 3
# RefSeq	NP_612440	NM_138431.2
# SIMILARITY	Belongs to the major facilitator superfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	MFSD3_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF103473	SSF103473
# UCSC	uc003zdi	human
# eggNOG	COG0477	LUCA
# eggNOG	KOG3574	Eukaryota
BLAST	swissprot:MFSD3_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:MFSD3_HUMAN
BioCyc	ZFISH:ENSG00000167700-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000167700-MONOMER
COG	COG0477	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477
COXPRESdb	113655	http://coxpresdb.jp/data/gene/113655.shtml
CleanEx	HS_MFSD3	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_MFSD3
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	BC011982	http://www.ebi.ac.uk/ena/data/view/BC011982
Ensembl	ENST00000301327	http://www.ensembl.org/id/ENST00000301327
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0008521	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008521
GO_function	GO:0015295	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015295
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GeneCards	MFSD3	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=MFSD3
GeneID	113655	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=113655
GeneTree	ENSGT00730000111292	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00730000111292
HGNC	HGNC:25157	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:25157
HOGENOM	HOG000217208	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000217208&db=HOGENOM6
HOVERGEN	HBG080578	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG080578&db=HOVERGEN
HPA	HPA056013	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA056013
InParanoid	Q96ES6	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96ES6
IntAct	Q96ES6	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96ES6*
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	113655	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=113655
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:113655	http://www.genome.jp/dbget-bin/www_bget?hsa:113655
KEGG_Orthology	KO:K08218	http://www.genome.jp/dbget-bin/www_bget?KO:K08218
MINT	MINT-1479139	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1479139
OMA	FPLWRIT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FPLWRIT
OrthoDB	EOG091G0JAA	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0JAA
PSORT	swissprot:MFSD3_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:MFSD3_HUMAN
PSORT-B	swissprot:MFSD3_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:MFSD3_HUMAN
PSORT2	swissprot:MFSD3_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:MFSD3_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA142671464	http://www.pharmgkb.org/do/serve?objId=PA142671464&objCls=Gene
Phobius	swissprot:MFSD3_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:MFSD3_HUMAN
PhylomeDB	Q96ES6	http://phylomedb.org/?seqid=Q96ES6
ProteinModelPortal	Q96ES6	http://www.proteinmodelportal.org/query/uniprot/Q96ES6
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
RefSeq	NP_612440	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_612440
STRING	9606.ENSP00000301327	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000301327&targetmode=cogs
STRING	COG0477	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
UCSC	uc003zdi	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003zdi&org=rat
UniGene	Hs.7678	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.7678
UniProtKB	MFSD3_HUMAN	http://www.uniprot.org/uniprot/MFSD3_HUMAN
UniProtKB-AC	Q96ES6	http://www.uniprot.org/uniprot/Q96ES6
charge	swissprot:MFSD3_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:MFSD3_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG3574	http://eggnogapi.embl.de/nog_data/html/tree/KOG3574
epestfind	swissprot:MFSD3_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:MFSD3_HUMAN
garnier	swissprot:MFSD3_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:MFSD3_HUMAN
helixturnhelix	swissprot:MFSD3_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:MFSD3_HUMAN
hmoment	swissprot:MFSD3_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:MFSD3_HUMAN
iep	swissprot:MFSD3_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:MFSD3_HUMAN
inforesidue	swissprot:MFSD3_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:MFSD3_HUMAN
neXtProt	NX_Q96ES6	http://www.nextprot.org/db/entry/NX_Q96ES6
octanol	swissprot:MFSD3_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:MFSD3_HUMAN
pepcoil	swissprot:MFSD3_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:MFSD3_HUMAN
pepdigest	swissprot:MFSD3_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:MFSD3_HUMAN
pepinfo	swissprot:MFSD3_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:MFSD3_HUMAN
pepnet	swissprot:MFSD3_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:MFSD3_HUMAN
pepstats	swissprot:MFSD3_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:MFSD3_HUMAN
pepwheel	swissprot:MFSD3_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:MFSD3_HUMAN
pepwindow	swissprot:MFSD3_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:MFSD3_HUMAN
sigcleave	swissprot:MFSD3_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:MFSD3_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S2610_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8NG04-1; Sequence=Displayed; Name=2; IsoId=Q8NG04-2; Sequence=VSP_034748, VSP_034749; Note=No experimental confirmation available.; 
# CAUTION	According to PubMed:12759755, it is a transcribed pseudogene. They however do not provide experimental evidences to support this affirmation. {ECO	0000305}. 
# CCDS	CCDS8949	-. [Q8NG04-1]
# Ensembl	ENST00000320442	ENSP00000320217; ENSG00000135502. [Q8NG04-1]
# ExpressionAtlas	Q8NG04	baseline and differential
# FUNCTION	S2610_HUMAN	Chloride/bicarbonate exchanger. {ECO 0000250}. 
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0005254	chloride channel activity; IBA:GO_Central.
# GO_function	GO:0008271	secondary active sulfate transmembrane transporter activity; IEA:InterPro.
# GO_function	GO:0015106	bicarbonate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015116	sulfate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0019531	oxalate transmembrane transporter activity; IBA:GO_Central.
# GO_function	S2610_HUMAN	GO 0015301 anion anion antiporter activity; IBA GO_Central.
# GO_process	GO:0015701	bicarbonate transport; IBA:GO_Central.
# GO_process	GO:0042391	regulation of membrane potential; IBA:GO_Central.
# GO_process	GO:0051453	regulation of intracellular pH; IBA:GO_Central.
# GO_process	GO:1902476	chloride transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.30.750.24	-; 1.
# Genevisible	Q8NG04	HS
# HGNC	HGNC:14470	SLC26A10
# InterPro	IPR001902	SLC26A/SulP_fam
# InterPro	IPR002645	STAS_dom
# InterPro	IPR011547	SLC26A/SulP_dom
# InterPro	IPR030324	SLC26A10
# KEGG_Brite	ko02001	Solute carrier family
# Organism	S2610_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11814	PTHR11814
# PANTHER	PTHR11814:SF99	PTHR11814:SF99
# PROSITE	PS50801	STAS
# Pfam	PF00916	Sulfate_transp
# Pfam	PF01740	STAS
# Proteomes	UP000005640	Chromosome 12
# RecName	S2610_HUMAN	Solute carrier family 26 member 10
# RefSeq	NP_597996	NM_133489.2. [Q8NG04-1]
# SEQUENCE CAUTION	Sequence=BAC85515.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. {ECO	0000305}. 
# SIMILARITY	Contains 1 STAS domain. {ECO:0000255|PROSITE- ProRule	PRU00198}. 
# SUBCELLULAR LOCATION	S2610_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF52091	SSF52091
# TCDB	2.A.53.2.13	the sulfate permease (sulp) family
# UCSC	uc001spe	human. [Q8NG04-1]
# eggNOG	COG0659	LUCA
# eggNOG	KOG0236	Eukaryota
BLAST	swissprot:S2610_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S2610_HUMAN
BioCyc	ZFISH:ENSG00000135502-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000135502-MONOMER
COXPRESdb	65012	http://coxpresdb.jp/data/gene/65012.shtml
CleanEx	HS_SLC26A10	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC26A10
DOI	10.1006/geno.2000.6355	http://dx.doi.org/10.1006/geno.2000.6355
DOI	10.1007/s00424-003-1090-3	http://dx.doi.org/10.1007/s00424-003-1090-3
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
EMBL	AC025165	http://www.ebi.ac.uk/ena/data/view/AC025165
EMBL	AF331523	http://www.ebi.ac.uk/ena/data/view/AF331523
EMBL	AK122981	http://www.ebi.ac.uk/ena/data/view/AK122981
Ensembl	ENST00000320442	http://www.ensembl.org/id/ENST00000320442
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_function	GO:0008271	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008271
GO_function	GO:0015106	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015106
GO_function	GO:0015116	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015116
GO_function	GO:0015301	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015301
GO_function	GO:0019531	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019531
GO_process	GO:0015701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015701
GO_process	GO:0042391	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042391
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.30.750.24	http://www.cathdb.info/version/latest/superfamily/3.30.750.24
GeneCards	SLC26A10	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC26A10
GeneID	65012	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=65012
GeneTree	ENSGT00760000119026	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119026
H-InvDB	HIX0037121	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0037121
H-InvDB	HIX0079408	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0079408
HGNC	HGNC:14470	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14470
HOGENOM	HOG000006546	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006546&db=HOGENOM6
HOVERGEN	HBG105688	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG105688&db=HOVERGEN
HPA	HPA044719	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA044719
InParanoid	Q8NG04	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8NG04
InterPro	IPR001902	http://www.ebi.ac.uk/interpro/entry/IPR001902
InterPro	IPR002645	http://www.ebi.ac.uk/interpro/entry/IPR002645
InterPro	IPR011547	http://www.ebi.ac.uk/interpro/entry/IPR011547
InterPro	IPR030324	http://www.ebi.ac.uk/interpro/entry/IPR030324
Jabion	65012	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=65012
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:65012	http://www.genome.jp/dbget-bin/www_bget?hsa:65012
KEGG_Orthology	KO:K14707	http://www.genome.jp/dbget-bin/www_bget?KO:K14707
OrthoDB	EOG091G07RT	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07RT
PANTHER	PTHR11814	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11814
PANTHER	PTHR11814:SF99	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11814:SF99
PROSITE	PS50801	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50801
PSORT	swissprot:S2610_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S2610_HUMAN
PSORT-B	swissprot:S2610_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S2610_HUMAN
PSORT2	swissprot:S2610_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S2610_HUMAN
Pfam	PF00916	http://pfam.xfam.org/family/PF00916
Pfam	PF01740	http://pfam.xfam.org/family/PF01740
PharmGKB	PA37887	http://www.pharmgkb.org/do/serve?objId=PA37887&objCls=Gene
Phobius	swissprot:S2610_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S2610_HUMAN
PhylomeDB	Q8NG04	http://phylomedb.org/?seqid=Q8NG04
ProteinModelPortal	Q8NG04	http://www.proteinmodelportal.org/query/uniprot/Q8NG04
PubMed	11087667	http://www.ncbi.nlm.nih.gov/pubmed/11087667
PubMed	12759755	http://www.ncbi.nlm.nih.gov/pubmed/12759755
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
RefSeq	NP_597996	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_597996
SMR	Q8NG04	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8NG04
STRING	9606.ENSP00000320217	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000320217&targetmode=cogs
SUPFAM	SSF52091	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52091
TCDB	2.A.53.2.13	http://www.tcdb.org/search/result.php?tc=2.A.53.2.13
UCSC	uc001spe	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001spe&org=rat
UniGene	Hs.727726	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.727726
UniProtKB	S2610_HUMAN	http://www.uniprot.org/uniprot/S2610_HUMAN
UniProtKB-AC	Q8NG04	http://www.uniprot.org/uniprot/Q8NG04
charge	swissprot:S2610_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S2610_HUMAN
eggNOG	COG0659	http://eggnogapi.embl.de/nog_data/html/tree/COG0659
eggNOG	KOG0236	http://eggnogapi.embl.de/nog_data/html/tree/KOG0236
epestfind	swissprot:S2610_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S2610_HUMAN
garnier	swissprot:S2610_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S2610_HUMAN
helixturnhelix	swissprot:S2610_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S2610_HUMAN
hmoment	swissprot:S2610_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S2610_HUMAN
iep	swissprot:S2610_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S2610_HUMAN
inforesidue	swissprot:S2610_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S2610_HUMAN
neXtProt	NX_Q8NG04	http://www.nextprot.org/db/entry/NX_Q8NG04
octanol	swissprot:S2610_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S2610_HUMAN
pepcoil	swissprot:S2610_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S2610_HUMAN
pepdigest	swissprot:S2610_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S2610_HUMAN
pepinfo	swissprot:S2610_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S2610_HUMAN
pepnet	swissprot:S2610_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S2610_HUMAN
pepstats	swissprot:S2610_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S2610_HUMAN
pepwheel	swissprot:S2610_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S2610_HUMAN
pepwindow	swissprot:S2610_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S2610_HUMAN
sigcleave	swissprot:S2610_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S2610_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCNKG_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=a; IsoId=Q96T55-1; Sequence=Displayed; Name=b; IsoId=Q96T55-3; Sequence=VSP_039865; Name=c; IsoId=Q96T55-4; Sequence=VSP_039863; Name=d; IsoId=Q96T55-5; Sequence=VSP_039864; 
# AltName	KCNKG_HUMAN	2P domain potassium channel Talk-1
# AltName	KCNKG_HUMAN	TWIK-related alkaline pH-activated K(+) channel 1
# BioGrid	123763	24
# CCDS	CCDS47420	-. [Q96T55-5]
# CCDS	CCDS47421	-. [Q96T55-4]
# CCDS	CCDS47422	-. [Q96T55-3]
# CCDS	CCDS4843	-. [Q96T55-1]
# Ensembl	ENST00000373227	ENSP00000362324; ENSG00000095981. [Q96T55-5]
# Ensembl	ENST00000373229	ENSP00000362326; ENSG00000095981. [Q96T55-1]
# Ensembl	ENST00000425054	ENSP00000391498; ENSG00000095981. [Q96T55-4]
# Ensembl	ENST00000437525	ENSP00000415375; ENSG00000095981. [Q96T55-3]
# ExpressionAtlas	Q96T55	baseline and differential
# FUNCTION	KCNKG_HUMAN	Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0005244	voltage-gated ion channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0005267	potassium channel activity; IDA:MGI.
# GO_function	GO:0022841	potassium ion leak channel activity; IBA:GO_Central.
# GO_process	GO:0006813	potassium ion transport; IDA:MGI.
# GO_process	GO:0030322	stabilization of membrane potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q96T55	HS
# HGNC	HGNC:14464	KCNK16
# INTERACTION	KCNKG_HUMAN	P32242 OTX1; NbExp=3; IntAct=EBI-10294109, EBI-740446; 
# IntAct	Q96T55	2
# InterPro	IPR003092	2pore_dom_K_chnl_TASK
# InterPro	IPR003280	2pore_dom_K_chnl
# InterPro	IPR013099	K_chnl_dom
# KEGG_Brite	ko04040	Ion channels
# MIM	607369	gene
# MISCELLANEOUS	KCNKG_HUMAN	Inhibited by Ba(2+), quinine, quinidine, chloroform and halothane. Activated at alkaline pH. 
# Organism	KCNKG_HUMAN	Homo sapiens (Human)
# PRINTS	PR01095	TASKCHANNEL
# PRINTS	PR01333	2POREKCHANEL
# Pfam	PF07885	Ion_trans_2; 2
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-1299361	TWIK-related alkaline pH activated K+ channel (TALK)
# Reactome	R-HSA-5576886	Phase 4 - resting membrane potential
# RecName	KCNKG_HUMAN	Potassium channel subfamily K member 16
# RefSeq	NP_001128577	NM_001135105.1. [Q96T55-4]
# RefSeq	NP_001128578	NM_001135106.1. [Q96T55-3]
# RefSeq	NP_001128579	NM_001135107.1. [Q96T55-5]
# RefSeq	NP_115491	NM_032115.3. [Q96T55-1]
# RefSeq	XP_016866835	XM_017011346.1. [Q96T55-5]
# SIMILARITY	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. {ECO	0000305}.
# SUBCELLULAR LOCATION	KCNKG_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	Homodimer. {ECO	0000305}. 
# TCDB	1.A.1.9.10	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	Highly expressed in pancreas. Not detectable in the other tissues tested. {ECO:0000269|PubMed	12724142}. 
# UCSC	uc003ooq	human. [Q96T55-1]
# eggNOG	COG1226	LUCA
# eggNOG	KOG1418	Eukaryota
BLAST	swissprot:KCNKG_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNKG_HUMAN
BioCyc	ZFISH:ENSG00000095981-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000095981-MONOMER
COXPRESdb	83795	http://coxpresdb.jp/data/gene/83795.shtml
CleanEx	HS_KCNK16	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNK16
DOI	10.1006/bbrc.2001.4562	http://dx.doi.org/10.1006/bbrc.2001.4562
DOI	10.1038/bjp.2008.213	http://dx.doi.org/10.1038/bjp.2008.213
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1152/ajpcell.00601.2002	http://dx.doi.org/10.1152/ajpcell.00601.2002
EMBL	AF358909	http://www.ebi.ac.uk/ena/data/view/AF358909
EMBL	AL136087	http://www.ebi.ac.uk/ena/data/view/AL136087
EMBL	AY253145	http://www.ebi.ac.uk/ena/data/view/AY253145
EMBL	AY253146	http://www.ebi.ac.uk/ena/data/view/AY253146
EMBL	AY253147	http://www.ebi.ac.uk/ena/data/view/AY253147
EMBL	BC111860	http://www.ebi.ac.uk/ena/data/view/BC111860
EMBL	CH471081	http://www.ebi.ac.uk/ena/data/view/CH471081
EMBL	CH471081	http://www.ebi.ac.uk/ena/data/view/CH471081
EMBL	CH471081	http://www.ebi.ac.uk/ena/data/view/CH471081
EMBL	EU978943	http://www.ebi.ac.uk/ena/data/view/EU978943
Ensembl	ENST00000373227	http://www.ensembl.org/id/ENST00000373227
Ensembl	ENST00000373229	http://www.ensembl.org/id/ENST00000373229
Ensembl	ENST00000425054	http://www.ensembl.org/id/ENST00000425054
Ensembl	ENST00000437525	http://www.ensembl.org/id/ENST00000437525
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005244
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_function	GO:0022841	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022841
GO_process	GO:0006813	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813
GO_process	GO:0030322	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030322
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	KCNK16	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNK16
GeneID	83795	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83795
GeneTree	ENSGT00760000118858	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118858
HGNC	HGNC:14464	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14464
HOVERGEN	HBG104884	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG104884&db=HOVERGEN
HPA	HPA016567	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA016567
InParanoid	Q96T55	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96T55
IntAct	Q96T55	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96T55*
InterPro	IPR003092	http://www.ebi.ac.uk/interpro/entry/IPR003092
InterPro	IPR003280	http://www.ebi.ac.uk/interpro/entry/IPR003280
InterPro	IPR013099	http://www.ebi.ac.uk/interpro/entry/IPR013099
Jabion	83795	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=83795
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:83795	http://www.genome.jp/dbget-bin/www_bget?hsa:83795
KEGG_Orthology	KO:K04924	http://www.genome.jp/dbget-bin/www_bget?KO:K04924
MIM	607369	http://www.ncbi.nlm.nih.gov/omim/607369
OMA	LQNYTCL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LQNYTCL
OrthoDB	EOG091G0E3R	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0E3R
PRINTS	PR01095	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01095
PRINTS	PR01333	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01333
PSORT	swissprot:KCNKG_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNKG_HUMAN
PSORT-B	swissprot:KCNKG_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNKG_HUMAN
PSORT2	swissprot:KCNKG_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNKG_HUMAN
Pfam	PF07885	http://pfam.xfam.org/family/PF07885
PharmGKB	PA30057	http://www.pharmgkb.org/do/serve?objId=PA30057&objCls=Gene
Phobius	swissprot:KCNKG_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNKG_HUMAN
PhylomeDB	Q96T55	http://phylomedb.org/?seqid=Q96T55
ProteinModelPortal	Q96T55	http://www.proteinmodelportal.org/query/uniprot/Q96T55
PubMed	11263999	http://www.ncbi.nlm.nih.gov/pubmed/11263999
PubMed	12724142	http://www.ncbi.nlm.nih.gov/pubmed/12724142
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	18516069	http://www.ncbi.nlm.nih.gov/pubmed/18516069
Reactome	R-HSA-1299361	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1299361
Reactome	R-HSA-5576886	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576886
RefSeq	NP_001128577	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001128577
RefSeq	NP_001128578	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001128578
RefSeq	NP_001128579	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001128579
RefSeq	NP_115491	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_115491
RefSeq	XP_016866835	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016866835
STRING	9606.ENSP00000391498	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000391498&targetmode=cogs
TCDB	1.A.1.9.10	http://www.tcdb.org/search/result.php?tc=1.A.1.9.10
UCSC	uc003ooq	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ooq&org=rat
UniGene	Hs.287765	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.287765
UniProtKB	KCNKG_HUMAN	http://www.uniprot.org/uniprot/KCNKG_HUMAN
UniProtKB-AC	Q96T55	http://www.uniprot.org/uniprot/Q96T55
charge	swissprot:KCNKG_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNKG_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG1418	http://eggnogapi.embl.de/nog_data/html/tree/KOG1418
epestfind	swissprot:KCNKG_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNKG_HUMAN
garnier	swissprot:KCNKG_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNKG_HUMAN
helixturnhelix	swissprot:KCNKG_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNKG_HUMAN
hmoment	swissprot:KCNKG_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNKG_HUMAN
iep	swissprot:KCNKG_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNKG_HUMAN
inforesidue	swissprot:KCNKG_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNKG_HUMAN
neXtProt	NX_Q96T55	http://www.nextprot.org/db/entry/NX_Q96T55
octanol	swissprot:KCNKG_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNKG_HUMAN
pepcoil	swissprot:KCNKG_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNKG_HUMAN
pepdigest	swissprot:KCNKG_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNKG_HUMAN
pepinfo	swissprot:KCNKG_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNKG_HUMAN
pepnet	swissprot:KCNKG_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNKG_HUMAN
pepstats	swissprot:KCNKG_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNKG_HUMAN
pepwheel	swissprot:KCNKG_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNKG_HUMAN
pepwindow	swissprot:KCNKG_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNKG_HUMAN
sigcleave	swissprot:KCNKG_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNKG_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S36A2_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q495M3-1; Sequence=Displayed; Name=2; IsoId=Q495M3-2; Sequence=VSP_032372; Note=No experimental confirmation available.; Name=3; IsoId=Q495M3-3; Sequence=VSP_032371, VSP_032373; Note=No experimental confirmation available.; 
# AltName	S36A2_HUMAN	Solute carrier family 36 member 2
# AltName	S36A2_HUMAN	Tramdorin-1
# CCDS	CCDS4315	-. [Q495M3-1]
# ChiTaRS	SLC36A2	human
# DISEASE	S36A2_HUMAN	Hyperglycinuria (HG) [MIM 138500]  A condition characterized by excess of glycine in the urine. In some cases it is associated with renal colic and renal oxalate stones. {ECO 0000269|PubMed 19033659}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	S36A2_HUMAN	Iminoglycinuria (IG) [MIM 242600]  A disorder of renal tubular reabsorption of glycine and imino acids (proline and hydroxyproline), marked by excessive levels of all three substances in the urine. {ECO 0000269|PubMed 19033659}. Note=The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Mutations in SLC36A2 that retain residual transport activity result in the IG phenotype only when combined with haploinsufficiency of the imino acid transporter SLC6A20 or deficiency of the neutral amino acid transporter SLC6A19. Additional polymorphisms and mutations in SLC6A18 can contribute to iminoglycinuria in some families. 
# DrugBank	DB00260	Cycloserine
# Ensembl	ENST00000335244	ENSP00000334223; ENSG00000186335. [Q495M3-1]
# ExpressionAtlas	Q495M3	baseline and differential
# FUNCTION	S36A2_HUMAN	Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids. Transports glycine and proline. Inhibited by sarcosine (By similarity). {ECO 0000250, ECO 0000269|PubMed 19033659}. 
# GO_component	GO:0005737	cytoplasm; IEA:UniProtKB-SubCell.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0015078	hydrogen ion transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015180	L-alanine transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015187	glycine transmembrane transporter activity; IMP:UniProtKB.
# GO_function	GO:0015193	L-proline transmembrane transporter activity; IBA:GO_Central.
# GO_function	S36A2_HUMAN	GO 0005280 hydrogen amino acid symporter activity; IBA GO_Central.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006865	amino acid transport; TAS:Reactome.
# GO_process	GO:0015824	proline transport; IEA:Ensembl.
# GO_process	GO:0035524	proline transmembrane transport; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# HGNC	HGNC:18762	SLC36A2
# InterPro	IPR013057	AA_transpt_TM
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H00905	[Urinary system disease; Kidney disease; Inherited metabolic disease] Iminoglycinuria
# KEGG_Disease	H01304	[Kidney disease] Hyperglycinuria
# MIM	138500	phenotype
# MIM	242600	phenotype
# MIM	608331	gene
# Organism	S36A2_HUMAN	Homo sapiens (Human)
# Orphanet	42062	Iminoglycinuria
# Pfam	PF01490	Aa_trans
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-352230	Amino acid transport across the plasma membrane
# Reactome	R-HSA-428559	Proton-coupled neutral amino acid transporters
# RecName	S36A2_HUMAN	Proton-coupled amino acid transporter 2
# RefSeq	NP_861441	NM_181776.2. [Q495M3-1]
# RefSeq	XP_016864573	XM_017009084.1. [Q495M3-2]
# SIMILARITY	Belongs to the amino acid/polyamine transporter 2 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S36A2_HUMAN	Cell membrane; Multi-pass membrane protein. Cytoplasm {ECO 0000250}. 
# TCDB	2.A.18.8	the amino acid/auxin permease (aaap) family
# TISSUE SPECIFICITY	S36A2_HUMAN	Abundantly expressed in kidney and muscle. Expressed in the S1 segment of the proximal tubule close to the glomerulus. {ECO 0000269|PubMed 15058382, ECO 0000269|PubMed 19033659}. 
# UCSC	uc003lty	human. [Q495M3-1]
# eggNOG	COG0814	LUCA
# eggNOG	KOG1304	Eukaryota
BLAST	swissprot:S36A2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S36A2_HUMAN
BioCyc	ZFISH:G66-33604-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33604-MONOMER
COXPRESdb	153201	http://coxpresdb.jp/data/gene/153201.shtml
CleanEx	HS_SLC36A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC36A2
DOI	10.1007/s00335-003-2319-3	http://dx.doi.org/10.1007/s00335-003-2319-3
DOI	10.1016/S0888-7543(03)00099-5	http://dx.doi.org/10.1016/S0888-7543(03)00099-5
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1172/JCI36625	http://dx.doi.org/10.1172/JCI36625
DrugBank	DB00260	http://www.drugbank.ca/drugs/DB00260
EMBL	AK122630	http://www.ebi.ac.uk/ena/data/view/AK122630
EMBL	AY162214	http://www.ebi.ac.uk/ena/data/view/AY162214
EMBL	BC101100	http://www.ebi.ac.uk/ena/data/view/BC101100
EMBL	BC101101	http://www.ebi.ac.uk/ena/data/view/BC101101
EMBL	BC101102	http://www.ebi.ac.uk/ena/data/view/BC101102
EMBL	BC101103	http://www.ebi.ac.uk/ena/data/view/BC101103
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
Ensembl	ENST00000335244	http://www.ensembl.org/id/ENST00000335244
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005280	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005280
GO_function	GO:0015078	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015078
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_function	GO:0015180	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015180
GO_function	GO:0015187	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015187
GO_function	GO:0015193	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015193
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006865	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865
GO_process	GO:0015824	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015824
GO_process	GO:0035524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035524
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC36A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC36A2
GeneID	153201	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=153201
GeneTree	ENSGT00390000011245	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000011245
HGNC	HGNC:18762	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18762
HOGENOM	HOG000006823	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006823&db=HOGENOM6
HOVERGEN	HBG057183	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG057183&db=HOVERGEN
HPA	HPA044002	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA044002
HPA	HPA062229	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA062229
InParanoid	Q495M3	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q495M3
IntAct	Q495M3	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q495M3*
InterPro	IPR013057	http://www.ebi.ac.uk/interpro/entry/IPR013057
Jabion	153201	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=153201
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H00905	http://www.genome.jp/dbget-bin/www_bget?H00905
KEGG_Disease	H01304	http://www.genome.jp/dbget-bin/www_bget?H01304
KEGG_Gene	hsa:153201	http://www.genome.jp/dbget-bin/www_bget?hsa:153201
KEGG_Orthology	KO:K14209	http://www.genome.jp/dbget-bin/www_bget?KO:K14209
MIM	138500	http://www.ncbi.nlm.nih.gov/omim/138500
MIM	242600	http://www.ncbi.nlm.nih.gov/omim/242600
MIM	608331	http://www.ncbi.nlm.nih.gov/omim/608331
OMA	CHYNETV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CHYNETV
Orphanet	42062	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=42062
OrthoDB	EOG091G079T	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G079T
PSORT	swissprot:S36A2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S36A2_HUMAN
PSORT-B	swissprot:S36A2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S36A2_HUMAN
PSORT2	swissprot:S36A2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S36A2_HUMAN
Pfam	PF01490	http://pfam.xfam.org/family/PF01490
PharmGKB	PA134899820	http://www.pharmgkb.org/do/serve?objId=PA134899820&objCls=Gene
Phobius	swissprot:S36A2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S36A2_HUMAN
PhylomeDB	Q495M3	http://phylomedb.org/?seqid=Q495M3
ProteinModelPortal	Q495M3	http://www.proteinmodelportal.org/query/uniprot/Q495M3
PubMed	12809675	http://www.ncbi.nlm.nih.gov/pubmed/12809675
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15058382	http://www.ncbi.nlm.nih.gov/pubmed/15058382
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19033659	http://www.ncbi.nlm.nih.gov/pubmed/19033659
Reactome	R-HSA-352230	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-352230
Reactome	R-HSA-428559	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428559
RefSeq	NP_861441	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_861441
RefSeq	XP_016864573	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016864573
STRING	9606.ENSP00000334223	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000334223&targetmode=cogs
TCDB	2.A.18.8	http://www.tcdb.org/search/result.php?tc=2.A.18.8
UCSC	uc003lty	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003lty&org=rat
UniGene	Hs.483877	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.483877
UniProtKB	S36A2_HUMAN	http://www.uniprot.org/uniprot/S36A2_HUMAN
UniProtKB-AC	Q495M3	http://www.uniprot.org/uniprot/Q495M3
charge	swissprot:S36A2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S36A2_HUMAN
eggNOG	COG0814	http://eggnogapi.embl.de/nog_data/html/tree/COG0814
eggNOG	KOG1304	http://eggnogapi.embl.de/nog_data/html/tree/KOG1304
epestfind	swissprot:S36A2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S36A2_HUMAN
garnier	swissprot:S36A2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S36A2_HUMAN
helixturnhelix	swissprot:S36A2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S36A2_HUMAN
hmoment	swissprot:S36A2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S36A2_HUMAN
iep	swissprot:S36A2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S36A2_HUMAN
inforesidue	swissprot:S36A2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S36A2_HUMAN
neXtProt	NX_Q495M3	http://www.nextprot.org/db/entry/NX_Q495M3
octanol	swissprot:S36A2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S36A2_HUMAN
pepcoil	swissprot:S36A2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S36A2_HUMAN
pepdigest	swissprot:S36A2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S36A2_HUMAN
pepinfo	swissprot:S36A2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S36A2_HUMAN
pepnet	swissprot:S36A2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S36A2_HUMAN
pepstats	swissprot:S36A2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S36A2_HUMAN
pepwheel	swissprot:S36A2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S36A2_HUMAN
pepwindow	swissprot:S36A2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S36A2_HUMAN
sigcleave	swissprot:S36A2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S36A2_HUMAN
## Database	ID	URL or Descriptions
# AltName	VPS35_HUMAN	Maternal-embryonic 3
# AltName	VPS35_HUMAN	Vesicle protein sorting 35
# BioGrid	120855	73
# ChiTaRS	VPS35	human
# DISEASE	VPS35_HUMAN	Parkinson disease 17 (PARK17) [MIM 614203]  An autosomal dominant, adult-onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. {ECO 0000269|PubMed 21763482, ECO 0000269|PubMed 21763483, ECO 0000269|PubMed 22517097}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000299138	ENSP00000299138; ENSG00000069329
# ExpressionAtlas	Q96QK1	baseline and differential
# FUNCTION	VPS35_HUMAN	Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R and SLC11A2. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed 15078903, PubMed 15247922, PubMed 20164305). Required for endosomal localization of FAM21C (PubMed 22070227). Mediates the association of the CSC with the WASH complex via FAM21 (PubMed 22070227, PubMed 24980502, PubMed 24819384). Required for the endosomal localization of TBC1D5 (PubMed 20923837). {ECO 0000269|PubMed 15078903, ECO 0000269|PubMed 15247922, ECO 0000269|PubMed 20164305, ECO 0000269|PubMed 20923837, ECO 0000269|PubMed 22070227, ECO 0000269|PubMed 23395371, ECO 0000269|PubMed 24819384, ECO 0000269|PubMed 24980502, ECO 0000303|PubMed 21725319, ECO 0000303|PubMed 22070227, ECO 0000303|PubMed 22513087, ECO 0000303|PubMed 23563491}. 
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005768	endosome; IDA:UniProtKB.
# GO_component	GO:0005769	early endosome; IDA:UniProtKB.
# GO_component	GO:0005770	late endosome; IBA:GO_Central.
# GO_component	GO:0005829	cytosol; IDA:UniProtKB.
# GO_component	GO:0010008	endosome membrane; IDA:ParkinsonsUK-UCL.
# GO_component	GO:0014069	postsynaptic density; IEA:Ensembl.
# GO_component	GO:0030904	retromer complex; IDA:ParkinsonsUK-UCL.
# GO_component	GO:0030906	retromer, cargo-selective complex; IDA:ParkinsonsUK-UCL.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_component	GO:0097422	tubular endosome; IDA:UniProtKB.
# GO_component	GO:0099073	mitochondrion-derived vesicle; IDA:ParkinsonsUK-UCL.
# GO_function	GO:0008565	protein transporter activity; IBA:GO_Central.
# GO_function	GO:0031748	D1 dopamine receptor binding; IPI:ParkinsonsUK-UCL.
# GO_process	GO:0006886	intracellular protein transport; IBA:GO_Central.
# GO_process	GO:0010628	positive regulation of gene expression; IDA:ParkinsonsUK-UCL.
# GO_process	GO:0010821	regulation of mitochondrion organization; IGI:ParkinsonsUK-UCL.
# GO_process	GO:0016055	Wnt signaling pathway; NAS:ParkinsonsUK-UCL.
# GO_process	GO:0016241	regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
# GO_process	GO:0031647	regulation of protein stability; IMP:ParkinsonsUK-UCL.
# GO_process	GO:0032268	regulation of cellular protein metabolic process; IDA:ParkinsonsUK-UCL.
# GO_process	GO:0042147	retrograde transport, endosome to Golgi; IMP:UniProtKB.
# GO_process	GO:0043653	mitochondrial fragmentation involved in apoptotic process; IMP:ParkinsonsUK-UCL.
# GO_process	GO:0045056	transcytosis; IDA:UniProtKB.
# GO_process	GO:0060161	positive regulation of dopamine receptor signaling pathway; IDA:ParkinsonsUK-UCL.
# GO_process	GO:0061357	positive regulation of Wnt protein secretion; IEA:Ensembl.
# GO_process	GO:0090141	positive regulation of mitochondrial fission; IMP:ParkinsonsUK-UCL.
# GO_process	GO:0090263	positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
# GO_process	GO:0099074	mitochondrion to lysosome transport; IMP:ParkinsonsUK-UCL.
# GO_process	GO:0099639	neurotransmitter receptor transport, endosome to plasma membrane; IDA:ParkinsonsUK-UCL.
# GO_process	GO:1902823	negative regulation of late endosome to lysosome transport; IMP:UniProtKB.
# GO_process	GO:1902950	regulation of dendritic spine maintenance; IMP:ParkinsonsUK-UCL.
# GO_process	GO:1990126	retrograde transport, endosome to plasma membrane; IMP:UniProtKB.
# GO_process	GO:2000331	regulation of terminal button organization; IMP:ParkinsonsUK-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007005	mitochondrion organization
# GOslim_process	GO:0007009	plasma membrane organization
# GOslim_process	GO:0007034	vacuolar transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# Genevisible	Q96QK1	HS
# HGNC	HGNC:13487	VPS35
# INTERACTION	VPS35_HUMAN	Q13596 SNX1; NbExp=2; IntAct=EBI-1054634, EBI-2822329; O75436 VPS26A; NbExp=7; IntAct=EBI-1054634, EBI-1043891; Q9UBQ0 VPS29; NbExp=5; IntAct=EBI-1054634, EBI-718596; 
# IntAct	Q96QK1	29
# InterPro	IPR005378	Vps35
# InterPro	IPR016024	ARM-type_fold
# MIM	601501	gene
# MIM	614203	phenotype
# Organism	VPS35_HUMAN	Homo sapiens (Human)
# Orphanet	2828	Young adult-onset Parkinsonism
# PANTHER	PTHR11099	PTHR11099
# PDB	2R17	X-ray; 2.80 A; C/D=483-780
# PIR	JC7516	JC7516
# Pfam	PF03635	Vps35
# Proteomes	UP000005640	Chromosome 16
# Reactome	R-HSA-3238698	WNT ligand biogenesis and trafficking
# RecName	VPS35_HUMAN	Vacuolar protein sorting-associated protein 35
# RefSeq	NP_060676	NM_018206.5
# SEQUENCE CAUTION	Sequence=AAG01989.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91137.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305}; Sequence=BAB14626.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
# SIMILARITY	Belongs to the VPS35 family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	VPS35_HUMAN	Cytoplasm. Membrane; Peripheral membrane protein. Endosome {ECO 0000269|PubMed 15078903}. Early endosome {ECO 0000305}. Late endosome {ECO 0000305}. Note=Localizes to tubular profiles adjacent to endosomes. {ECO 0000269|PubMed 15078903}. 
# SUBUNIT	VPS35_HUMAN	Component of the heterotrimeric retromer cargo-selective complex (CSC), also decribed as vacuolar protein sorting subcomplex (VPS), formed by VPS26 (VPS26A or VPS26B), VPS29 and VPS35 (PubMed 11102511). The CSC has a highly elongated structure with VPS26 and VPS29 binding independently at opposite distal ends of VPS35 as central platform (By similarity). The CSC is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants. The originally described retromer complex (also called SNX-BAR retromer) is a pentamer containing the CSC and a heterodimeric membrane-deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the respective CSC and SNX-BAR subcomplexes associate with low affinity. The CSC associates with SNX3 to form a SNX3-retromer complex. The CSC associates with SNX27, the WASH complex and the SNX-BAR subcomplex to form the SNX27-retromer complex (Probable). Interacts with VPS26A, VPS26B, VPS29, SNX1, SNX2, IGF2R, SNX3, GOLPH3, LRRK2, SLC11A2, FAM21A, FAM21C, FKBP15, WASH1, RAB7A, SNX27, KIAA0196, EHD1 (PubMed 11102511, PubMed 15078903, PubMed 17868075PubMed 22070227, PubMed 19553991, PubMed 21725319, PubMed 22070227, PubMed 22513087, PubMed 23331060, PubMed 23563491, PubMed 23395371, PubMed 24344282, PubMed 24980502, PubMed 17891154, PubMed 19531583). Interacts with MAGEL2; leading to recruitment of the TRIM27 MAGEL2 E3 ubiquitin ligase complex retromer-containing endosomes (PubMed 23452853). {ECO 0000250, ECO 0000269|PubMed 11102511, ECO 0000269|PubMed 15078903, ECO 0000269|PubMed 17868075, ECO 0000269|PubMed 17891154, ECO 0000269|PubMed 19553991, ECO 0000269|PubMed 21725319, ECO 0000269|PubMed 22070227, ECO 0000269|PubMed 22513087, ECO 0000269|PubMed 23331060, ECO 0000269|PubMed 23395371, ECO 0000269|PubMed 23452853, ECO 0000269|PubMed 23563491, ECO 0000269|PubMed 24344282, ECO 0000269|PubMed 24980502, ECO 0000303|PubMed 21725319, ECO 0000303|PubMed 23563491}. 
# SUPFAM	SSF48371	SSF48371; 3
# TISSUE SPECIFICITY	VPS35_HUMAN	Ubiquitous. Highly expressed in heart, brain, placenta, skeletal muscle, spleen, thymus, testis, ovary, small intestine, kidney and colon. 
# UCSC	uc002eef	human
# eggNOG	ENOG410XNXC	LUCA
# eggNOG	KOG1107	Eukaryota
BLAST	swissprot:VPS35_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VPS35_HUMAN
BioCyc	ZFISH:ENSG00000069329-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000069329-MONOMER
COXPRESdb	55737	http://coxpresdb.jp/data/gene/55737.shtml
DIP	DIP-29076N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29076N
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/bbrc.2000.3727	http://dx.doi.org/10.1006/bbrc.2000.3727
DOI	10.1006/geno.2000.6380	http://dx.doi.org/10.1006/geno.2000.6380
DOI	10.1016/j.ajhg.2011.06.001	http://dx.doi.org/10.1016/j.ajhg.2011.06.001
DOI	10.1016/j.ajhg.2011.06.008	http://dx.doi.org/10.1016/j.ajhg.2011.06.008
DOI	10.1016/j.cell.2013.01.051	http://dx.doi.org/10.1016/j.cell.2013.01.051
DOI	10.1016/j.cub.2014.06.024	http://dx.doi.org/10.1016/j.cub.2014.06.024
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.neuron.2012.11.033	http://dx.doi.org/10.1016/j.neuron.2012.11.033
DOI	10.1038/nature06216	http://dx.doi.org/10.1038/nature06216
DOI	10.1038/nature08109	http://dx.doi.org/10.1038/nature08109
DOI	10.1038/ncb1153	http://dx.doi.org/10.1038/ncb1153
DOI	10.1038/ncb2281	http://dx.doi.org/10.1038/ncb2281
DOI	10.1038/ncb2721	http://dx.doi.org/10.1038/ncb2721
DOI	10.1038/ncomms4828	http://dx.doi.org/10.1038/ncomms4828
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/BJ20111761	http://dx.doi.org/10.1042/BJ20111761
DOI	10.1073/pnas.1316482111	http://dx.doi.org/10.1073/pnas.1316482111
DOI	10.1083/jcb.200312055	http://dx.doi.org/10.1083/jcb.200312055
DOI	10.1091/mbc.11.12.4105	http://dx.doi.org/10.1091/mbc.11.12.4105
DOI	10.1091/mbc.E11-12-1059	http://dx.doi.org/10.1091/mbc.E11-12-1059
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1101/gr.GR1547R	http://dx.doi.org/10.1101/gr.GR1547R
DOI	10.1111/boc.201200038	http://dx.doi.org/10.1111/boc.201200038
DOI	10.1111/j.1600-0854.2007.00652.x	http://dx.doi.org/10.1111/j.1600-0854.2007.00652.x
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1212/WNL.0b013e318253d5f2	http://dx.doi.org/10.1212/WNL.0b013e318253d5f2
DOI	10.1242/jcs.048686	http://dx.doi.org/10.1242/jcs.048686
DOI	10.1242/jcs.060574	http://dx.doi.org/10.1242/jcs.060574
DOI	10.1242/jcs.071472	http://dx.doi.org/10.1242/jcs.071472
EMBL	AF175265	http://www.ebi.ac.uk/ena/data/view/AF175265
EMBL	AF183418	http://www.ebi.ac.uk/ena/data/view/AF183418
EMBL	AF186382	http://www.ebi.ac.uk/ena/data/view/AF186382
EMBL	AF191298	http://www.ebi.ac.uk/ena/data/view/AF191298
EMBL	AK000395	http://www.ebi.ac.uk/ena/data/view/AK000395
EMBL	AK001614	http://www.ebi.ac.uk/ena/data/view/AK001614
EMBL	AK023650	http://www.ebi.ac.uk/ena/data/view/AK023650
EMBL	AL136888	http://www.ebi.ac.uk/ena/data/view/AL136888
EMBL	AL512769	http://www.ebi.ac.uk/ena/data/view/AL512769
EMBL	AY007112	http://www.ebi.ac.uk/ena/data/view/AY007112
EMBL	BC002414	http://www.ebi.ac.uk/ena/data/view/BC002414
EMBL	BC010362	http://www.ebi.ac.uk/ena/data/view/BC010362
EMBL	BC093036	http://www.ebi.ac.uk/ena/data/view/BC093036
Ensembl	ENST00000299138	http://www.ensembl.org/id/ENST00000299138
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GO_component	GO:0005769	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005769
GO_component	GO:0005770	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005770
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0010008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010008
GO_component	GO:0014069	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014069
GO_component	GO:0030904	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030904
GO_component	GO:0030906	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030906
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_component	GO:0097422	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097422
GO_component	GO:0099073	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0099073
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0031748	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031748
GO_process	GO:0006886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006886
GO_process	GO:0010628	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010628
GO_process	GO:0010821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010821
GO_process	GO:0016055	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016055
GO_process	GO:0016241	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016241
GO_process	GO:0031647	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031647
GO_process	GO:0032268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032268
GO_process	GO:0042147	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042147
GO_process	GO:0043653	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043653
GO_process	GO:0045056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045056
GO_process	GO:0060161	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060161
GO_process	GO:0061357	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061357
GO_process	GO:0090141	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090141
GO_process	GO:0090263	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090263
GO_process	GO:0099074	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0099074
GO_process	GO:0099639	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0099639
GO_process	GO:1902823	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902823
GO_process	GO:1902950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902950
GO_process	GO:1990126	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990126
GO_process	GO:2000331	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000331
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007005
GOslim_process	GO:0007009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007009
GOslim_process	GO:0007034	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007034
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GeneCards	VPS35	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=VPS35
GeneID	55737	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55737
GeneTree	ENSGT00390000007315	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000007315
HGNC	HGNC:13487	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13487
HOVERGEN	HBG054277	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054277&db=HOVERGEN
HPA	HPA040802	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA040802
InParanoid	Q96QK1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q96QK1
IntAct	Q96QK1	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96QK1*
InterPro	IPR005378	http://www.ebi.ac.uk/interpro/entry/IPR005378
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
Jabion	55737	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55737
KEGG_Gene	hsa:55737	http://www.genome.jp/dbget-bin/www_bget?hsa:55737
MIM	601501	http://www.ncbi.nlm.nih.gov/omim/601501
MIM	614203	http://www.ncbi.nlm.nih.gov/omim/614203
MINT	MINT-5001902	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5001902
OMA	LWIRMEA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LWIRMEA
Orphanet	2828	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=2828
OrthoDB	EOG091G0OHF	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0OHF
PANTHER	PTHR11099	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11099
PDB	2R17	http://www.ebi.ac.uk/pdbe-srv/view/entry/2R17
PDBsum	2R17	http://www.ebi.ac.uk/pdbsum/2R17
PSORT	swissprot:VPS35_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VPS35_HUMAN
PSORT-B	swissprot:VPS35_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VPS35_HUMAN
PSORT2	swissprot:VPS35_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VPS35_HUMAN
Pfam	PF03635	http://pfam.xfam.org/family/PF03635
PharmGKB	PA37783	http://www.pharmgkb.org/do/serve?objId=PA37783&objCls=Gene
Phobius	swissprot:VPS35_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VPS35_HUMAN
PhylomeDB	Q96QK1	http://phylomedb.org/?seqid=Q96QK1
ProteinModelPortal	Q96QK1	http://www.proteinmodelportal.org/query/uniprot/Q96QK1
PubMed	11062004	http://www.ncbi.nlm.nih.gov/pubmed/11062004
PubMed	11102511	http://www.ncbi.nlm.nih.gov/pubmed/11102511
PubMed	11112353	http://www.ncbi.nlm.nih.gov/pubmed/11112353
PubMed	11230166	http://www.ncbi.nlm.nih.gov/pubmed/11230166
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15078903	http://www.ncbi.nlm.nih.gov/pubmed/15078903
PubMed	15247922	http://www.ncbi.nlm.nih.gov/pubmed/15247922
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17868075	http://www.ncbi.nlm.nih.gov/pubmed/17868075
PubMed	17891154	http://www.ncbi.nlm.nih.gov/pubmed/17891154
PubMed	19531583	http://www.ncbi.nlm.nih.gov/pubmed/19531583
PubMed	19553991	http://www.ncbi.nlm.nih.gov/pubmed/19553991
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	20164305	http://www.ncbi.nlm.nih.gov/pubmed/20164305
PubMed	20923837	http://www.ncbi.nlm.nih.gov/pubmed/20923837
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21725319	http://www.ncbi.nlm.nih.gov/pubmed/21725319
PubMed	21763482	http://www.ncbi.nlm.nih.gov/pubmed/21763482
PubMed	21763483	http://www.ncbi.nlm.nih.gov/pubmed/21763483
PubMed	22070227	http://www.ncbi.nlm.nih.gov/pubmed/22070227
PubMed	22513087	http://www.ncbi.nlm.nih.gov/pubmed/22513087
PubMed	22517097	http://www.ncbi.nlm.nih.gov/pubmed/22517097
PubMed	23331060	http://www.ncbi.nlm.nih.gov/pubmed/23331060
PubMed	23395371	http://www.ncbi.nlm.nih.gov/pubmed/23395371
PubMed	23452853	http://www.ncbi.nlm.nih.gov/pubmed/23452853
PubMed	23563491	http://www.ncbi.nlm.nih.gov/pubmed/23563491
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	24344282	http://www.ncbi.nlm.nih.gov/pubmed/24344282
PubMed	24819384	http://www.ncbi.nlm.nih.gov/pubmed/24819384
PubMed	24980502	http://www.ncbi.nlm.nih.gov/pubmed/24980502
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-3238698	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3238698
RefSeq	NP_060676	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060676
SMR	Q96QK1	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q96QK1
STRING	9606.ENSP00000299138	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000299138&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
UCSC	uc002eef	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002eef&org=rat
UniGene	Hs.454528	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.454528
UniGene	Hs.595143	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.595143
UniProtKB	VPS35_HUMAN	http://www.uniprot.org/uniprot/VPS35_HUMAN
UniProtKB-AC	Q96QK1	http://www.uniprot.org/uniprot/Q96QK1
charge	swissprot:VPS35_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VPS35_HUMAN
eggNOG	ENOG410XNXC	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNXC
eggNOG	KOG1107	http://eggnogapi.embl.de/nog_data/html/tree/KOG1107
epestfind	swissprot:VPS35_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VPS35_HUMAN
garnier	swissprot:VPS35_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VPS35_HUMAN
helixturnhelix	swissprot:VPS35_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VPS35_HUMAN
hmoment	swissprot:VPS35_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VPS35_HUMAN
iep	swissprot:VPS35_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VPS35_HUMAN
inforesidue	swissprot:VPS35_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VPS35_HUMAN
neXtProt	NX_Q96QK1	http://www.nextprot.org/db/entry/NX_Q96QK1
octanol	swissprot:VPS35_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VPS35_HUMAN
pepcoil	swissprot:VPS35_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VPS35_HUMAN
pepdigest	swissprot:VPS35_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VPS35_HUMAN
pepinfo	swissprot:VPS35_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VPS35_HUMAN
pepnet	swissprot:VPS35_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VPS35_HUMAN
pepstats	swissprot:VPS35_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VPS35_HUMAN
pepwheel	swissprot:VPS35_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VPS35_HUMAN
pepwindow	swissprot:VPS35_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VPS35_HUMAN
sigcleave	swissprot:VPS35_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VPS35_HUMAN
## Database	ID	URL or Descriptions
# AltName	Delayed rectifier potassium channel 1 {ECO:0000303|PubMed	8081723}
# AltName	Voltage-gated potassium channel subunit Kv2.1 {ECO:0000303|PubMed	8081723}
# BIOPHYSICOCHEMICAL PROPERTIES	KCNB1_HUMAN	Kinetic parameters  Note=Homotetrameric channels expressed in xenopus oocytes or in mammalian non-neuronal cells display delayed-rectifier voltage- dependent potassium currents which are activated during membrane depolarization, i.e within a risetime of about 20 msec (PubMed 8081723, PubMed 1283219). After that, inactivate very slowly, i.e within more than 5 sec (PubMed 8081723, PubMed 1283219). Their activation requires low threshold potentials of about -20 to -30 mV, with a midpoint activation at about 10 mV. For inactivation, the voltage at half-maximal amplitude is about -20 mV (PubMed 11852086). The time constant for recovery after inactivation is about 1.6 sec. Channels have an unitary conductance of about 8 pS (PubMed 10484328). The voltage-dependence of activation and inactivation and other channel characteristics vary depending on the experimental conditions, the expression system, the presence or absence of ancillary subunits and post-translational modifications. {ECO 0000250|UniProtKB P15387, ECO 0000269|PubMed 10484328, ECO 0000269|PubMed 11852086, ECO 0000269|PubMed 1283219, ECO 0000269|PubMed 8081723, ECO 0000305|PubMed 10414301, ECO 0000305|PubMed 15858231}; 
# BioGrid	109947	15
# DISEASE	KCNB1_HUMAN	Epileptic encephalopathy, early infantile, 26 (EIEE26) [MIM 616056]  A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. EIEE26 patients manifest multiple types of seizures, delayed psychomotor development, poor or absent speech, hypotonia, hypsarrhythmia. {ECO 0000269|PubMed 25164438, ECO 0000269|PubMed 26477325, ECO 0000269|PubMed 26503721}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DOMAIN	KCNB1_HUMAN	The N-terminal and C-terminal cytoplasmic regions mediate homooligomerization; self-association is required to regulate trafficking, gating and C-terminal phosphorylation-dependent modulation of the channel (PubMed 11852086, PubMed 12060745, PubMed 12560340, PubMed 19074135, PubMed 24901643). The N-terminal cytoplasmic region is important for interaction with other channel-forming alpha subunits and with ancillary beta subunits (PubMed 24901643). The C-terminus is necessary and sufficient for the restricted localization to, and clustering within, both in soma and proximal portions of dendrite of neurons and in lateral membrane of non-neuronal polarized cells. The C-terminus is both necessary and sufficient as a mediator of cholinergic and calcium- stimulated modulation of channel cell membrane clustering localization and activity in hippocampal neurons (By similarity). {ECO 0000250|UniProtKB P15387, ECO 0000269|PubMed 11852086, ECO 0000269|PubMed 12060745, ECO 0000269|PubMed 12560340, ECO 0000269|PubMed 19074135, ECO 0000269|PubMed 24901643}. 
# DOMAIN	KCNB1_HUMAN	The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. {ECO 0000250|UniProtKB P63142}. 
# DrugBank	DB06637	Dalfampridine
# ENZYME REGULATION	KCNB1_HUMAN	Inhibited by 12.7 nM stromatoxin 1 (ScTx1), a spider venom toxin of the tarantula S.calceata (PubMed 14565763). Inhibited by 42 nM hanatoxin 1 (HaTx1), a spider venom toxin of the tarantula G.spatulata (PubMed 14565763). Modestly sensitive to millimolar levels of tetraethylammonium (TEA) (PubMed 8081723, PubMed 1283219). Modestly sensitive to millimolar levels of 4- aminopyridine (4-AP). Completely insensitive to toxins such as dendrotoxin (DTX) and charybdotoxin (CTX) (By similarity). {ECO 0000250|UniProtKB P15387, ECO 0000269|PubMed 1283219, ECO 0000269|PubMed 14565763, ECO 0000269|PubMed 8081723, ECO 0000305|PubMed 10414301, ECO 0000305|PubMed 15858231}. 
# Ensembl	ENST00000371741	ENSP00000360806; ENSG00000158445
# Ensembl	ENST00000635465	ENSP00000489193; ENSG00000158445
# FUNCTION	KCNB1_HUMAN	Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain (PubMed 23161216). Plays also a role in the regulation of exocytosis independently of its electrical function (By similarity). Forms tetrameric potassium- selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization (PubMed 8081723, PubMed 1283219, PubMed 10484328, PubMed 12560340, PubMed 19074135, PubMed 19717558, PubMed 24901643). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB2; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1, creating a functionally diverse range of channel complexes (PubMed 10484328, PubMed 11852086, PubMed 12060745, PubMed 19074135, PubMed 19717558, PubMed 24901643). Heterotetrameric channel activity formed with KCNS3 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity). Channel properties are also modulated by cytoplasmic ancillary beta subunits such as AMIGO1, KCNE1, KCNE2 and KCNE3, slowing activation and inactivation rate of the delayed rectifier potassium channels (By similarity). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Major contributor to the slowly inactivating delayed-rectifier voltage- gated potassium current in neurons of the central nervous system, sympathetic ganglion neurons, neuroendocrine cells, pancreatic beta cells, cardiomyocytes and smooth muscle cells. Mediates the major part of the somatodendritic delayed-rectifier potassium current in hippocampal and cortical pyramidal neurons and sympathetic superior cervical ganglion (CGC) neurons that acts to slow down periods of firing, especially during high frequency stimulation. Plays a role in the induction of long-term potentiation (LTP) of neuron excitability in the CA3 layer of the hippocampus (By similarity). Contributes to the regulation of glucose-induced action potential amplitude and duration in pancreatic beta cells, hence limiting calcium influx and insulin secretion (PubMed 23161216). Plays a role in the regulation of resting membrane potential and contraction in hypoxia-treated pulmonary artery smooth muscle cells. May contribute to the regulation of the duration of both the action potential of cardiomyocytes and the heart ventricular repolarization QT interval. Contributes to the pronounced pro-apoptotic potassium current surge during neuronal apoptotic cell death in response to oxidative injury. May confer neuroprotection in response to hypoxia/ischemic insults by suppressing pyramidal neurons hyperexcitability in hippocampal and cortical regions (By similarity). Promotes trafficking of KCNG3, KCNH1 and KCNH2 to the cell surface membrane, presumably by forming heterotetrameric channels with these subunits (PubMed 12060745). Plays a role in the calcium-dependent recruitment and release of fusion-competent vesicles from the soma of neurons, neuroendocrine and glucose- induced pancreatic beta cells by binding key components of the fusion machinery in a pore-independent manner (By similarity). {ECO 0000250|UniProtKB P15387, ECO 0000250|UniProtKB Q03717, ECO 0000269|PubMed 10484328, ECO 0000269|PubMed 11852086, ECO 0000269|PubMed 12060745, ECO 0000269|PubMed 12560340, ECO 0000269|PubMed 1283219, ECO 0000269|PubMed 19074135, ECO 0000269|PubMed 19717558, ECO 0000269|PubMed 23161216, ECO 0000269|PubMed 24901643, ECO 0000269|PubMed 8081723}. 
# GO_component	GO:0005622	intracellular; IEA:GOC.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0008076	voltage-gated potassium channel complex; IDA:UniProtKB.
# GO_component	GO:0016328	lateral plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030424	axon; ISS:UniProtKB.
# GO_component	GO:0030425	dendrite; ISS:UniProtKB.
# GO_component	GO:0032809	neuronal cell body membrane; ISS:UniProtKB.
# GO_component	GO:0042383	sarcolemma; IEA:UniProtKB-SubCell.
# GO_component	GO:0043204	perikaryon; ISS:UniProtKB.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0005251	delayed rectifier potassium channel activity; IDA:UniProtKB.
# GO_function	GO:0032182	ubiquitin-like protein binding; IPI:UniProtKB.
# GO_function	GO:0044325	ion channel binding; IPI:UniProtKB.
# GO_function	GO:0046982	protein heterodimerization activity; ISS:UniProtKB.
# GO_process	GO:0001508	action potential; IDA:UniProtKB.
# GO_process	GO:0006904	vesicle docking involved in exocytosis; ISS:UniProtKB.
# GO_process	GO:0007215	glutamate receptor signaling pathway; ISS:UniProtKB.
# GO_process	GO:0010701	positive regulation of norepinephrine secretion; ISS:UniProtKB.
# GO_process	GO:0031669	cellular response to nutrient levels; ISS:UniProtKB.
# GO_process	GO:0033605	positive regulation of catecholamine secretion; ISS:UniProtKB.
# GO_process	GO:0042593	glucose homeostasis; ISS:UniProtKB.
# GO_process	GO:0045956	positive regulation of calcium ion-dependent exocytosis; ISS:UniProtKB.
# GO_process	GO:0046676	negative regulation of insulin secretion; ISS:UniProtKB.
# GO_process	GO:0050796	regulation of insulin secretion; TAS:Reactome.
# GO_process	GO:0051260	protein homooligomerization; IEA:InterPro.
# GO_process	GO:0071333	cellular response to glucose stimulus; ISS:UniProtKB.
# GO_process	GO:0071805	potassium ion transmembrane transport; IDA:UniProtKB.
# GO_process	GO:0072661	protein targeting to plasma membrane; ISS:UniProtKB.
# GO_process	GO:0090314	positive regulation of protein targeting to membrane; IDA:UniProtKB.
# GO_process	GO:0098900	regulation of action potential; ISS:UniProtKB.
# GO_process	GO:1900454	positive regulation of long term synaptic depression; ISS:UniProtKB.
# GO_process	GO:2000671	regulation of motor neuron apoptotic process; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005622	intracellular
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0032182	ubiquitin-like protein binding
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006605	protein targeting
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0016192	vesicle-mediated transport
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# GOslim_process	GO:0061024	membrane organization
# Gene3D	1.20.120.350	-; 1.
# Genevisible	Q14721	HS
# HGNC	HGNC:6231	KCNB1
# InterPro	IPR000210	BTB/POZ_dom
# InterPro	IPR003131	T1-type_BTB
# InterPro	IPR003968	K_chnl_volt-dep_Kv
# InterPro	IPR003973	K_chnl_volt-dep_Kv2
# InterPro	IPR004350	K_chnl_volt-dep_Kv2.1
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR011333	SKP1/BTB/POZ
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028325	VG_K_chnl
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04742	Taste transduction
# MIM	600397	gene
# MIM	616056	phenotype
# Organism	KCNB1_HUMAN	Homo sapiens (Human)
# Orphanet	1934	Early infantile epileptic encephalopathy
# PANTHER	PTHR11537	PTHR11537
# PIR	S31761	S31761
# PRINTS	PR00169	KCHANNEL
# PRINTS	PR01491	KVCHANNEL
# PRINTS	PR01495	SHABCHANNEL
# PRINTS	PR01514	KV21CHANNEL
# PTM	KCNB1_HUMAN	Acetylated. Acetylation occurs in pancreatic beta cells in response to stimulation by incretin hormones in a histone acetyltransferase (HAT)/histone deacetylase (HDAC)-dependent signaling pathway, promoting beta cell survival. {ECO 0000250|UniProtKB P15387}. 
# PTM	KCNB1_HUMAN	Phosphorylated. Differential C-terminal phosphorylation on a subset of serines allows graded activity-dependent regulation of channel gating in hippocampal neurons. Ser-607 and Tyr-128 are significant sites of voltage-gated regulation through phosphorylation/dephosphorylation activities. Tyr-128 can be phosphorylated by Src and dephosphorylated by cytoplasmic form of the phosphatase PTPRE. CDK5-induced Ser-607 phosphorylation increases in response to acute blockade of neuronal activity. Phosphorylated on Tyr-128 by Src and on Ser-805 by MAPK14/P38MAPK; phosphorylations are necessary and sufficient for an increase in plasma membrane insertion, apoptotic potassium current surge and completion of the neuronal cell death program. Phosphorylated on Ser-520, Ser-607, Ser-656 and Ser-805 by CDK5; phosphorylation is necessary for KCNB1 channel clustering formation. The Ser-607 phosphorylation state differs between KCNB1-containing clusters on the proximal and distal portions of the axon initial segment (AIS). Highly phosphorylated on serine residues in the C-terminal cytoplasmic tail in resting neurons. Phosphorylated in pancreatic beta cells in response to incretin hormones stimulation in a PKA- and RPS6KA5/MSK1-dependent signaling pathway, promoting beta cell survival. Phosphorylation on Ser-567 is reduced during postnatal development with low levels at P2 and P5; levels then increase to reach adult levels by P14. Phosphorylation on Ser-457, Ser-541, Ser-567, Ser-607, Ser-656 and Ser-720 as well as the N-terminal Ser-15 are sensitive to calcineurin-mediated dephosphorylation contributing to the modulation of the voltage-dependent gating properties. Dephosphorylation by phosphatase PTPRE confers neuroprotection by its inhibitory influence on the neuronal apoptotic potassium current surge in a Zn(2+)-dependent manner. Dephosphorylated at Ser-607 by protein phosphatase PPP1CA. Hypoxia-, seizure- or glutamate-induced neuronal activity promote calcium/calcineurin-dependent dephosphorylation resulting in a loss of KCNB1-containing clustering and enhanced channel activity. In response to brain ischemia, Ser-567 and Ser-607 are strongly dephosphorylated while Ser-457 and Ser-720 are less dephosphorylated. In response to brain seizures, phosphorylation levels on Ser-567 and Ser-607 are greatly reduced. Phosphorylated/dephosphorylated by Src or FYN tyrosine-protein kinases and tyrosine phosphatase PTPRE in primary Schwann cells and sciatic nerve tissue (By similarity). {ECO 0000250|UniProtKB P15387, ECO 0000250|UniProtKB Q03717}. 
# PTM	KCNB1_HUMAN	Sumoylated on Lys-474, preferentially with SUMO1; sumoylation induces a positive shift in the voltage-dependence of activation and inhibits channel activity (PubMed 19223394). Sumoylation increases the frequency of repetitive action potential firing at the cell surface of hippocampal neurons and decreases its frequency in pancreatic beta cells (PubMed 19223394). Desumoylated by SENP1 (PubMed 19223394). {ECO 0000269|PubMed 19223394}. 
# Pfam	PF00520	Ion_trans
# Pfam	PF02214	BTB_2
# Pfam	PF03521	Kv2channel; 2
# Proteomes	UP000005640	Chromosome 20
# Reactome	R-HSA-1296072	Voltage gated Potassium channels
# Reactome	R-HSA-381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
# RecName	Potassium voltage-gated channel subfamily B member 1 {ECO:0000312|HGNC	HGNC:6231}
# RefSeq	NP_004966	NM_004975.3
# RefSeq	XP_006723847	XM_006723784.3
# RefSeq	XP_011527101	XM_011528799.2
# SEQUENCE CAUTION	Sequence=AAA36156.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily. {ECO	0000305}. 
# SMART	SM00225	BTB
# SUBCELLULAR LOCATION	KCNB1_HUMAN	Cell membrane {ECO 0000269|PubMed 10484328, ECO 0000269|PubMed 11852086, ECO 0000269|PubMed 12060745, ECO 0000269|PubMed 12560340, ECO 0000269|PubMed 1283219, ECO 0000269|PubMed 19074135, ECO 0000269|PubMed 19223394, ECO 0000269|PubMed 19717558, ECO 0000269|PubMed 24477962, ECO 0000269|PubMed 24901643, ECO 0000269|PubMed 26503721, ECO 0000269|PubMed 8081723}. Perikaryon {ECO 0000269|PubMed 24477962}. Cell projection, axon {ECO 0000269|PubMed 24477962}. Cell projection, dendrite {ECO 0000269|PubMed 24477962}. Membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane {ECO 0000250|UniProtKB P15387}. Cell junction, synapse {ECO 0000250|UniProtKB P15387}. Cell junction, synapse, synaptosome {ECO 0000250|UniProtKB P15387}. Lateral cell membrane {ECO 0000250|UniProtKB P15387}. Cell membrane, sarcolemma {ECO 0000250|UniProtKB P15387}. Note=Localizes to high-density somatodendritic clusters and non-clustered sites on the surface of neocortical and hippocampal pyramidal neurons in a cortical actin cytoskeleton-dependent manner (PubMed 24477962). Localizes also to high-density clusters in the axon initial segment (AIS), at ankyrin-G-deficient sites, on the surface of neocortical and hippocampal pyramidal neurons (PubMed 24477962). KCNB1-containing AIS clusters localize either in close apposition to smooth endoplasmic reticulum cisternal organelles or with GABA-A receptor-containing synapses of hippocampal and cortical pyramidal neurons, respectively (PubMed 24477962). Localizes to high-density clusters on the cell surface of atrial and ventricular myocytes and at the lateral plasma membrane in epithelial cells. Localizes both to the axial and transverse tubules (T tubule) and sarcolemma in ventricular myocytes. Associated with lipid raft domains. In cortical neurons, apoptotic injuries induce de novo plasma membrane insertion in a SNARE-dependent manner causing an apoptotic potassium current surge. {ECO 0000250|UniProtKB P15387, ECO 0000250|UniProtKB Q03717, ECO 0000269|PubMed 12060745, ECO 0000269|PubMed 19074135, ECO 0000269|PubMed 24477962, ECO 0000269|PubMed 24901643}. 
# SUBUNIT	KCNB1_HUMAN	Homotetramer or heterotetramer with KCNB2 (PubMed 8081723, PubMed 1283219). Heterotetramer with non- conducting channel-forming alpha subunits such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1 (PubMed 10484328, PubMed 11852086, PubMed 12060745, PubMed 19357235, PubMed 19074135, PubMed 19717558, PubMed 24901643). Channel activity is regulated by association with ancillary beta subunits such as AMIGO1, KCNE1, KCNE2 and KCNE3 (By similarity). Self-associates (via N-terminus and C- terminus) (PubMed 12560340, PubMed 24901643); self-association is required to regulate trafficking, gating and C-terminal phosphorylation-dependent modulation of the channel (By similarity). Interacts (via C-terminus) with STX1A (via C- terminus); this decreases the rate of channel activation and increases the rate of channel inactivation in pancreatic beta cells, induces also neuronal apoptosis in response to oxidative injury as well as pore-independent enhancement of exocytosis in neuroendocrine cells, chromaffin cells, pancreatic beta cells and from the soma of dorsal root ganglia (DRG) neurons. Interacts (via N-terminus) with SNAP25; this decreases the rate of channel inactivation in pancreatic beta cells and also increases interaction during neuronal apoptosis in a N-methyl-D-aspartate receptor (NMDAR)-dependent manner. Interacts (via N-terminus and C-terminus) with VAMP2 (via N-terminus); stimulates channel inactivation rate. Interacts with CREB1; this promotes channel acetylation in response to stimulation of incretin hormones. Interacts (via N-terminus and C-terminus) with MYL12B. Interacts (via N-terminus) with PIAS3; this increases the number of functional channels at the cell surface (By similarity). Interacts with SUMO1 (PubMed 19223394). Interacts (via phosphorylated form) with PTPRE; this reduces phosphorylation and channel activity in heterologous cells (By similarity). {ECO 0000250|UniProtKB P15387, ECO 0000250|UniProtKB Q03717, ECO 0000269|PubMed 10484328, ECO 0000269|PubMed 11852086, ECO 0000269|PubMed 12060745, ECO 0000269|PubMed 12560340, ECO 0000269|PubMed 1283219, ECO 0000269|PubMed 19074135, ECO 0000269|PubMed 19223394, ECO 0000269|PubMed 19357235, ECO 0000269|PubMed 19717558, ECO 0000269|PubMed 24901643, ECO 0000269|PubMed 8081723}. 
# SUPFAM	SSF54695	SSF54695
# TCDB	1.A.1.2.11	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	KCNB1_HUMAN	Expressed in neocortical pyramidal cells (PubMed 24477962). Expressed in pancreatic beta cells (at protein level) (PubMed 12403834, PubMed 14988243). Expressed in brain, heart, lung, liver, colon, kidney and adrenal gland (PubMed 19074135). Expressed in the cortex, amygdala, cerebellum, pons, thalamus, hypothalamus, hippocampus and substantia nigra (PubMed 19074135). {ECO 0000269|PubMed 12403834, ECO 0000269|PubMed 14988243, ECO 0000269|PubMed 19074135, ECO 0000269|PubMed 24477962}. 
# UCSC	uc002xur	human
# eggNOG	COG1226	LUCA
# eggNOG	KOG3713	Eukaryota
BLAST	swissprot:KCNB1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCNB1_HUMAN
BioCyc	ZFISH:ENSG00000158445-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000158445-MONOMER
COXPRESdb	3745	http://coxpresdb.jp/data/gene/3745.shtml
CleanEx	HS_KCNB1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNB1
DOI	10.1002/ana.24263	http://dx.doi.org/10.1002/ana.24263
DOI	10.1002/cne.23551	http://dx.doi.org/10.1002/cne.23551
DOI	10.1007/BF00370422	http://dx.doi.org/10.1007/BF00370422
DOI	10.1016/S0014-5793(02)02267-6	http://dx.doi.org/10.1016/S0014-5793(02)02267-6
DOI	10.1021/tx0341097	http://dx.doi.org/10.1021/tx0341097
DOI	10.1038/414865a	http://dx.doi.org/10.1038/414865a
DOI	10.1038/srep15199	http://dx.doi.org/10.1038/srep15199
DOI	10.1073/pnas.122617999	http://dx.doi.org/10.1073/pnas.122617999
DOI	10.1074/jbc.M109.039479	http://dx.doi.org/10.1074/jbc.M109.039479
DOI	10.1074/jbc.M212973200	http://dx.doi.org/10.1074/jbc.M212973200
DOI	10.1074/jbc.M808786200	http://dx.doi.org/10.1074/jbc.M808786200
DOI	10.1085/jgp.201511444	http://dx.doi.org/10.1085/jgp.201511444
DOI	10.1111/j.1749-6632.1999.tb11293.x	http://dx.doi.org/10.1111/j.1749-6632.1999.tb11293.x
DOI	10.1124/jpet.112.199083	http://dx.doi.org/10.1124/jpet.112.199083
DOI	10.1152/ajpcell.00088.2009	http://dx.doi.org/10.1152/ajpcell.00088.2009
DOI	10.1210/me.2002-0058	http://dx.doi.org/10.1210/me.2002-0058
DOI	10.1242/jcs.036632	http://dx.doi.org/10.1242/jcs.036632
DOI	10.1371/journal.pone.0098960	http://dx.doi.org/10.1371/journal.pone.0098960
DOI	10.1385/CBB:42:2:167	http://dx.doi.org/10.1385/CBB:42:2:167
DOI	10.2337/diabetes.53.3.597	http://dx.doi.org/10.2337/diabetes.53.3.597
DrugBank	DB06637	http://www.drugbank.ca/drugs/DB06637
EMBL	AF026005	http://www.ebi.ac.uk/ena/data/view/AF026005
EMBL	AL035685	http://www.ebi.ac.uk/ena/data/view/AL035685
EMBL	L02840	http://www.ebi.ac.uk/ena/data/view/L02840
EMBL	X68302	http://www.ebi.ac.uk/ena/data/view/X68302
Ensembl	ENST00000371741	http://www.ensembl.org/id/ENST00000371741
Ensembl	ENST00000635465	http://www.ensembl.org/id/ENST00000635465
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_component	GO:0016328	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016328
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030424	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030424
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0032809	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032809
GO_component	GO:0042383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042383
GO_component	GO:0043204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043204
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0005251	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005251
GO_function	GO:0032182	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032182
GO_function	GO:0044325	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044325
GO_function	GO:0046982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046982
GO_process	GO:0001508	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001508
GO_process	GO:0006904	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006904
GO_process	GO:0007215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007215
GO_process	GO:0010701	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010701
GO_process	GO:0031669	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031669
GO_process	GO:0033605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033605
GO_process	GO:0042593	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042593
GO_process	GO:0045956	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045956
GO_process	GO:0046676	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046676
GO_process	GO:0050796	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050796
GO_process	GO:0051260	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260
GO_process	GO:0071333	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071333
GO_process	GO:0071805	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805
GO_process	GO:0072661	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072661
GO_process	GO:0090314	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090314
GO_process	GO:0098900	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098900
GO_process	GO:1900454	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900454
GO_process	GO:2000671	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000671
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005622	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0032182	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032182
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0016192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016192
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	KCNB1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNB1
GeneID	3745	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3745
GeneTree	ENSGT00760000118981	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118981
HGNC	HGNC:6231	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6231
HOGENOM	HOG000113206	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000113206&db=HOGENOM6
HOVERGEN	HBG052225	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052225&db=HOVERGEN
HPA	CAB001979	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB001979
HPA	HPA042434	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042434
InParanoid	Q14721	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q14721
IntAct	Q14721	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q14721*
InterPro	IPR000210	http://www.ebi.ac.uk/interpro/entry/IPR000210
InterPro	IPR003131	http://www.ebi.ac.uk/interpro/entry/IPR003131
InterPro	IPR003968	http://www.ebi.ac.uk/interpro/entry/IPR003968
InterPro	IPR003973	http://www.ebi.ac.uk/interpro/entry/IPR003973
InterPro	IPR004350	http://www.ebi.ac.uk/interpro/entry/IPR004350
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR011333	http://www.ebi.ac.uk/interpro/entry/IPR011333
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028325	http://www.ebi.ac.uk/interpro/entry/IPR028325
Jabion	3745	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3745
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:3745	http://www.genome.jp/dbget-bin/www_bget?hsa:3745
KEGG_Orthology	KO:K04885	http://www.genome.jp/dbget-bin/www_bget?KO:K04885
KEGG_Pathway	ko04742	http://www.genome.jp/kegg-bin/show_pathway?ko04742
MIM	600397	http://www.ncbi.nlm.nih.gov/omim/600397
MIM	616056	http://www.ncbi.nlm.nih.gov/omim/616056
OMA	TEGVIDM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TEGVIDM
Orphanet	1934	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1934
OrthoDB	EOG091G0FP3	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0FP3
PANTHER	PTHR11537	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537
PRINTS	PR00169	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00169
PRINTS	PR01491	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01491
PRINTS	PR01495	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01495
PRINTS	PR01514	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01514
PSORT	swissprot:KCNB1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCNB1_HUMAN
PSORT-B	swissprot:KCNB1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCNB1_HUMAN
PSORT2	swissprot:KCNB1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCNB1_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF02214	http://pfam.xfam.org/family/PF02214
Pfam	PF03521	http://pfam.xfam.org/family/PF03521
PharmGKB	PA209	http://www.pharmgkb.org/do/serve?objId=PA209&objCls=Gene
Phobius	swissprot:KCNB1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCNB1_HUMAN
PhylomeDB	Q14721	http://phylomedb.org/?seqid=Q14721
ProteinModelPortal	Q14721	http://www.proteinmodelportal.org/query/uniprot/Q14721
PubMed	10414301	http://www.ncbi.nlm.nih.gov/pubmed/10414301
PubMed	10484328	http://www.ncbi.nlm.nih.gov/pubmed/10484328
PubMed	11780052	http://www.ncbi.nlm.nih.gov/pubmed/11780052
PubMed	11852086	http://www.ncbi.nlm.nih.gov/pubmed/11852086
PubMed	12060745	http://www.ncbi.nlm.nih.gov/pubmed/12060745
PubMed	12403834	http://www.ncbi.nlm.nih.gov/pubmed/12403834
PubMed	12560340	http://www.ncbi.nlm.nih.gov/pubmed/12560340
PubMed	1283219	http://www.ncbi.nlm.nih.gov/pubmed/1283219
PubMed	14565763	http://www.ncbi.nlm.nih.gov/pubmed/14565763
PubMed	14988243	http://www.ncbi.nlm.nih.gov/pubmed/14988243
PubMed	15858231	http://www.ncbi.nlm.nih.gov/pubmed/15858231
PubMed	19074135	http://www.ncbi.nlm.nih.gov/pubmed/19074135
PubMed	19223394	http://www.ncbi.nlm.nih.gov/pubmed/19223394
PubMed	19357235	http://www.ncbi.nlm.nih.gov/pubmed/19357235
PubMed	19717558	http://www.ncbi.nlm.nih.gov/pubmed/19717558
PubMed	23161216	http://www.ncbi.nlm.nih.gov/pubmed/23161216
PubMed	24477962	http://www.ncbi.nlm.nih.gov/pubmed/24477962
PubMed	24901643	http://www.ncbi.nlm.nih.gov/pubmed/24901643
PubMed	25164438	http://www.ncbi.nlm.nih.gov/pubmed/25164438
PubMed	26477325	http://www.ncbi.nlm.nih.gov/pubmed/26477325
PubMed	26503721	http://www.ncbi.nlm.nih.gov/pubmed/26503721
PubMed	8081723	http://www.ncbi.nlm.nih.gov/pubmed/8081723
Reactome	R-HSA-1296072	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1296072
Reactome	R-HSA-381676	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-381676
RefSeq	NP_004966	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004966
RefSeq	XP_006723847	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006723847
RefSeq	XP_011527101	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011527101
SMART	SM00225	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225
SMR	Q14721	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q14721
STRING	9606.ENSP00000360806	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000360806&targetmode=cogs
SUPFAM	SSF54695	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54695
TCDB	1.A.1.2.11	http://www.tcdb.org/search/result.php?tc=1.A.1.2.11
UCSC	uc002xur	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002xur&org=rat
UniGene	Hs.633143	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.633143
UniGene	Hs.84244	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.84244
UniProtKB	KCNB1_HUMAN	http://www.uniprot.org/uniprot/KCNB1_HUMAN
UniProtKB-AC	Q14721	http://www.uniprot.org/uniprot/Q14721
charge	swissprot:KCNB1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCNB1_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	KOG3713	http://eggnogapi.embl.de/nog_data/html/tree/KOG3713
epestfind	swissprot:KCNB1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCNB1_HUMAN
garnier	swissprot:KCNB1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCNB1_HUMAN
helixturnhelix	swissprot:KCNB1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCNB1_HUMAN
hmoment	swissprot:KCNB1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCNB1_HUMAN
iep	swissprot:KCNB1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCNB1_HUMAN
inforesidue	swissprot:KCNB1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCNB1_HUMAN
neXtProt	NX_Q14721	http://www.nextprot.org/db/entry/NX_Q14721
octanol	swissprot:KCNB1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCNB1_HUMAN
pepcoil	swissprot:KCNB1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCNB1_HUMAN
pepdigest	swissprot:KCNB1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCNB1_HUMAN
pepinfo	swissprot:KCNB1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCNB1_HUMAN
pepnet	swissprot:KCNB1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCNB1_HUMAN
pepstats	swissprot:KCNB1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCNB1_HUMAN
pepwheel	swissprot:KCNB1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCNB1_HUMAN
pepwindow	swissprot:KCNB1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCNB1_HUMAN
sigcleave	swissprot:KCNB1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCNB1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CTSR4_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7RTX7-1; Sequence=Displayed; Name=2; IsoId=Q7RTX7-2; Sequence=VSP_026979, VSP_026980; Note=No experimental confirmation available.; 
# BioGrid	132049	4
# CCDS	CCDS30645	-. [Q7RTX7-1]
# ENZYME REGULATION	CTSR4_HUMAN	The CatSper calcium channel is indirectly activated by extracellular progesterone and prostaglandins following the sequence  progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2 (PubMed 21412338, PubMed 21412339, PubMed 26989199). The CatSper calcium channel is directly inhibited by endocannabinoid 2-arachidonoylglycerol (2AG) (PubMed 26989199). Indirect activation by progesterone takes place via the following mechanism  progesterone binds and activates the acylglycerol lipase ABHD2, which in turn mediates hydrolysis of 2AG inhibitor, relieving inhibition of the CatSper channel (PubMed 26989199). The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers (PubMed 21412338, PubMed 21412339). Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH (PubMed 21412338, PubMed 21412339). {ECO 0000269|PubMed 21412338, ECO 0000269|PubMed 21412339, ECO 0000269|PubMed 26989199}. 
# Ensembl	ENST00000456354	ENSP00000390423; ENSG00000188782. [Q7RTX7-1]
# Ensembl	ENST00000518899	ENSP00000429464; ENSG00000188782. [Q7RTX7-2]
# ExpressionAtlas	Q7RTX7	baseline and differential
# FUNCTION	CTSR4_HUMAN	Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. {ECO 0000269|PubMed 21412338, ECO 0000269|PubMed 21412339}. 
# GO_component	GO:0001669	acrosomal vesicle; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0036128	CatSper complex; ISS:UniProtKB.
# GO_component	GO:0097228	sperm principal piece; IEA:Ensembl.
# GO_function	GO:0005227	calcium activated cation channel activity; IEA:InterPro.
# GO_function	GO:0005245	voltage-gated calcium channel activity; IEA:Ensembl.
# GO_function	GO:0005248	voltage-gated sodium channel activity; IBA:GO_Central.
# GO_process	GO:0007275	multicellular organism development; IEA:UniProtKB-KW.
# GO_process	GO:0019228	neuronal action potential; IBA:GO_Central.
# GO_process	GO:0030317	flagellated sperm motility; IEA:Ensembl.
# GO_process	GO:0032570	response to progesterone; TAS:Reactome.
# GO_process	GO:0035036	sperm-egg recognition; TAS:Reactome.
# GO_process	GO:0048240	sperm capacitation; IEA:Ensembl.
# GO_process	GO:0086010	membrane depolarization during action potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0021700	developmental maturation
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0048870	cell motility
# Gene3D	1.20.120.350	-; 1.
# HGNC	HGNC:23220	CATSPER4
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR028744	CatSper4
# MIM	609121	gene
# Organism	CTSR4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10037:SF225	PTHR10037:SF225; 2
# Pfam	PF00520	Ion_trans
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-1300642	Sperm Motility And Taxes
# RecName	CTSR4_HUMAN	Cation channel sperm-associated protein 4
# RefSeq	NP_937770	NM_198137.1. [Q7RTX7-1]
# SEQUENCE CAUTION	Sequence=AAI28139.1; Type=Frameshift; Positions=21; Evidence={ECO:0000305}; Sequence=CAH71538.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the cation channel sperm-associated (TC 1.A.1.19) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	CTSR4_HUMAN	Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of sperm tail. 
# SUBUNIT	Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Component of the CatSper complex. Interacts with CATSPER1 (By similarity). {ECO:0000250, ECO	0000305}. 
# TCDB	1.A.1.19	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	CTSR4_HUMAN	Testis-specific. {ECO 0000269|PubMed 12932298, ECO 0000269|PubMed 17347248}. 
# UCSC	uc009vsf	human. [Q7RTX7-1]
# eggNOG	COG1226	LUCA
# eggNOG	ENOG410II5Y	Eukaryota
BLAST	swissprot:CTSR4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CTSR4_HUMAN
BioCyc	ZFISH:G66-31009-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-31009-MONOMER
COXPRESdb	378807	http://coxpresdb.jp/data/gene/378807.shtml
CleanEx	HS_CATSPER4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CATSPER4
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/nature09767	http://dx.doi.org/10.1038/nature09767
DOI	10.1038/nature09769	http://dx.doi.org/10.1038/nature09769
DOI	10.1093/molehr/gam009	http://dx.doi.org/10.1093/molehr/gam009
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.aad6887	http://dx.doi.org/10.1126/science.aad6887
DOI	10.1186/1477-7827-1-53	http://dx.doi.org/10.1186/1477-7827-1-53
EMBL	AL355877	http://www.ebi.ac.uk/ena/data/view/AL355877
EMBL	BC128138	http://www.ebi.ac.uk/ena/data/view/BC128138
EMBL	BC128139	http://www.ebi.ac.uk/ena/data/view/BC128139
EMBL	BN000273	http://www.ebi.ac.uk/ena/data/view/BN000273
Ensembl	ENST00000456354	http://www.ensembl.org/id/ENST00000456354
Ensembl	ENST00000518899	http://www.ensembl.org/id/ENST00000518899
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0001669	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001669
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0036128	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036128
GO_component	GO:0097228	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097228
GO_function	GO:0005227	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005227
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0005248	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005248
GO_process	GO:0007275	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007275
GO_process	GO:0019228	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019228
GO_process	GO:0030317	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030317
GO_process	GO:0032570	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032570
GO_process	GO:0035036	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035036
GO_process	GO:0048240	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048240
GO_process	GO:0086010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086010
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0021700	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021700
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	CATSPER4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CATSPER4
GeneID	378807	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=378807
GeneTree	ENSGT00760000119325	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119325
HGNC	HGNC:23220	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:23220
HOGENOM	HOG000112053	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000112053&db=HOGENOM6
HOVERGEN	HBG102124	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG102124&db=HOVERGEN
HPA	HPA045257	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA045257
InParanoid	Q7RTX7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q7RTX7
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR028744	http://www.ebi.ac.uk/interpro/entry/IPR028744
Jabion	378807	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=378807
KEGG_Gene	hsa:378807	http://www.genome.jp/dbget-bin/www_bget?hsa:378807
MIM	609121	http://www.ncbi.nlm.nih.gov/omim/609121
PANTHER	PTHR10037:SF225	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10037:SF225
PSORT	swissprot:CTSR4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CTSR4_HUMAN
PSORT-B	swissprot:CTSR4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CTSR4_HUMAN
PSORT2	swissprot:CTSR4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CTSR4_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
PharmGKB	PA134941696	http://www.pharmgkb.org/do/serve?objId=PA134941696&objCls=Gene
Phobius	swissprot:CTSR4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CTSR4_HUMAN
PhylomeDB	Q7RTX7	http://phylomedb.org/?seqid=Q7RTX7
ProteinModelPortal	Q7RTX7	http://www.proteinmodelportal.org/query/uniprot/Q7RTX7
PubMed	12932298	http://www.ncbi.nlm.nih.gov/pubmed/12932298
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17347248	http://www.ncbi.nlm.nih.gov/pubmed/17347248
PubMed	21412338	http://www.ncbi.nlm.nih.gov/pubmed/21412338
PubMed	21412339	http://www.ncbi.nlm.nih.gov/pubmed/21412339
PubMed	26989199	http://www.ncbi.nlm.nih.gov/pubmed/26989199
Reactome	R-HSA-1300642	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1300642
RefSeq	NP_937770	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_937770
STRING	9606.ENSP00000390423	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000390423&targetmode=cogs
TCDB	1.A.1.19	http://www.tcdb.org/search/result.php?tc=1.A.1.19
UCSC	uc009vsf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc009vsf&org=rat
UniGene	Hs.123532	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.123532
UniProtKB	CTSR4_HUMAN	http://www.uniprot.org/uniprot/CTSR4_HUMAN
UniProtKB-AC	Q7RTX7	http://www.uniprot.org/uniprot/Q7RTX7
charge	swissprot:CTSR4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CTSR4_HUMAN
eggNOG	COG1226	http://eggnogapi.embl.de/nog_data/html/tree/COG1226
eggNOG	ENOG410II5Y	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410II5Y
epestfind	swissprot:CTSR4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CTSR4_HUMAN
garnier	swissprot:CTSR4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CTSR4_HUMAN
helixturnhelix	swissprot:CTSR4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CTSR4_HUMAN
hmoment	swissprot:CTSR4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CTSR4_HUMAN
iep	swissprot:CTSR4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CTSR4_HUMAN
inforesidue	swissprot:CTSR4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CTSR4_HUMAN
neXtProt	NX_Q7RTX7	http://www.nextprot.org/db/entry/NX_Q7RTX7
octanol	swissprot:CTSR4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CTSR4_HUMAN
pepcoil	swissprot:CTSR4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CTSR4_HUMAN
pepdigest	swissprot:CTSR4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CTSR4_HUMAN
pepinfo	swissprot:CTSR4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CTSR4_HUMAN
pepnet	swissprot:CTSR4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CTSR4_HUMAN
pepstats	swissprot:CTSR4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CTSR4_HUMAN
pepwheel	swissprot:CTSR4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CTSR4_HUMAN
pepwindow	swissprot:CTSR4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CTSR4_HUMAN
sigcleave	swissprot:CTSR4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CTSR4_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	122138	40
# Ensembl	ENST00000255305	ENSP00000255305; ENSG00000132953
# ExpressionAtlas	Q9C0E2	baseline and differential
# FUNCTION	XPO4_HUMAN	Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO 0000269|PubMed 10944119, ECO 0000269|PubMed 16449645}. 
# GO_component	GO:0005643	nuclear pore; IBA:GO_Central.
# GO_component	GO:0005654	nucleoplasm; IDA:HPA.
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_function	GO:0005049	nuclear export signal receptor activity; IBA:GO_Central.
# GO_function	GO:0008536	Ran GTPase binding; IBA:GO_Central.
# GO_process	GO:0046827	positive regulation of protein export from nucleus; IMP:BHF-UCL.
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.25.10.10	-; 1.
# Genevisible	Q9C0E2	HS
# HGNC	HGNC:17796	XPO4
# InterPro	IPR011989	ARM-like
# InterPro	IPR014877	CRM1_C_dom
# InterPro	IPR016024	ARM-type_fold
# MIM	611449	gene
# Organism	XPO4_HUMAN	Homo sapiens (Human)
# Pfam	PF08767	CRM1_C
# Proteomes	UP000005640	Chromosome 13
# RecName	XPO4_HUMAN	Exportin-4
# RefSeq	NP_071904	NM_022459.4
# SEQUENCE CAUTION	Sequence=BAB14409.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the exportin family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	XPO4_HUMAN	Cytoplasm {ECO 0000269|PubMed 16449645}. Nucleus {ECO 0000269|PubMed 16449645}. Note=Shuttles between the nucleus and the cytoplasm. 
# SUBUNIT	XPO4_HUMAN	Found in a complex with XPO4, Ran and EIF5A. Found in a complex with XPO4, Ran and SMAD3. Interacts with SMAD3. Interacts with Ran and cargo proteins in a GTP-dependent manner. {ECO 0000269|PubMed 10944119, ECO 0000269|PubMed 16449645}. 
# SUPFAM	SSF48371	SSF48371; 5
# TCDB	1.I.1.1	the nuclear pore complex (npc) family
# UCSC	uc001unq	human
# eggNOG	ENOG410XNNN	LUCA
# eggNOG	KOG4541	Eukaryota
BLAST	swissprot:XPO4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:XPO4_HUMAN
BioCyc	ZFISH:ENSG00000132953-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000132953-MONOMER
COXPRESdb	64328	http://coxpresdb.jp/data/gene/64328.shtml
CleanEx	HS_XPO4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_XPO4
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature02379	http://dx.doi.org/10.1038/nature02379
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1093/dnares/7.6.347	http://dx.doi.org/10.1093/dnares/7.6.347
DOI	10.1093/emboj/19.16.4362	http://dx.doi.org/10.1093/emboj/19.16.4362
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1128/MCB.26.4.1318-1332.2006	http://dx.doi.org/10.1128/MCB.26.4.1318-1332.2006
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AB051508	http://www.ebi.ac.uk/ena/data/view/AB051508
EMBL	AK023108	http://www.ebi.ac.uk/ena/data/view/AK023108
EMBL	AL356285	http://www.ebi.ac.uk/ena/data/view/AL356285
EMBL	AL356285	http://www.ebi.ac.uk/ena/data/view/AL356285
EMBL	AL512652	http://www.ebi.ac.uk/ena/data/view/AL512652
EMBL	AL512652	http://www.ebi.ac.uk/ena/data/view/AL512652
EMBL	AL831819	http://www.ebi.ac.uk/ena/data/view/AL831819
Ensembl	ENST00000255305	http://www.ensembl.org/id/ENST00000255305
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005643	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005643
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_function	GO:0005049	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005049
GO_function	GO:0008536	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008536
GO_process	GO:0046827	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046827
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
GeneCards	XPO4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=XPO4
GeneID	64328	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64328
GeneTree	ENSGT00730000111055	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00730000111055
H-InvDB	HIX0011162	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0011162
HGNC	HGNC:17796	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17796
HOGENOM	HOG000154878	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000154878&db=HOGENOM6
HOVERGEN	HBG023214	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG023214&db=HOVERGEN
HPA	HPA053768	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA053768
InParanoid	Q9C0E2	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9C0E2
IntAct	Q9C0E2	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9C0E2*
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR014877	http://www.ebi.ac.uk/interpro/entry/IPR014877
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
Jabion	64328	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=64328
KEGG_Gene	hsa:64328	http://www.genome.jp/dbget-bin/www_bget?hsa:64328
MIM	611449	http://www.ncbi.nlm.nih.gov/omim/611449
OMA	KQFARRS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KQFARRS
PSORT	swissprot:XPO4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:XPO4_HUMAN
PSORT-B	swissprot:XPO4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:XPO4_HUMAN
PSORT2	swissprot:XPO4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:XPO4_HUMAN
Pfam	PF08767	http://pfam.xfam.org/family/PF08767
PharmGKB	PA134866468	http://www.pharmgkb.org/do/serve?objId=PA134866468&objCls=Gene
Phobius	swissprot:XPO4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:XPO4_HUMAN
PhylomeDB	Q9C0E2	http://phylomedb.org/?seqid=Q9C0E2
ProteinModelPortal	Q9C0E2	http://www.proteinmodelportal.org/query/uniprot/Q9C0E2
PubMed	10944119	http://www.ncbi.nlm.nih.gov/pubmed/10944119
PubMed	11214970	http://www.ncbi.nlm.nih.gov/pubmed/11214970
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15057823	http://www.ncbi.nlm.nih.gov/pubmed/15057823
PubMed	16449645	http://www.ncbi.nlm.nih.gov/pubmed/16449645
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
RefSeq	NP_071904	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_071904
SMR	Q9C0E2	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9C0E2
STRING	9606.ENSP00000255305	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000255305&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
TCDB	1.I.1.1	http://www.tcdb.org/search/result.php?tc=1.I.1.1
UCSC	uc001unq	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001unq&org=rat
UniGene	Hs.507452	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.507452
UniProtKB	XPO4_HUMAN	http://www.uniprot.org/uniprot/XPO4_HUMAN
UniProtKB-AC	Q9C0E2	http://www.uniprot.org/uniprot/Q9C0E2
charge	swissprot:XPO4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:XPO4_HUMAN
eggNOG	ENOG410XNNN	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNNN
eggNOG	KOG4541	http://eggnogapi.embl.de/nog_data/html/tree/KOG4541
epestfind	swissprot:XPO4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:XPO4_HUMAN
garnier	swissprot:XPO4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:XPO4_HUMAN
helixturnhelix	swissprot:XPO4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:XPO4_HUMAN
hmoment	swissprot:XPO4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:XPO4_HUMAN
iep	swissprot:XPO4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:XPO4_HUMAN
inforesidue	swissprot:XPO4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:XPO4_HUMAN
neXtProt	NX_Q9C0E2	http://www.nextprot.org/db/entry/NX_Q9C0E2
octanol	swissprot:XPO4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:XPO4_HUMAN
pepcoil	swissprot:XPO4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:XPO4_HUMAN
pepdigest	swissprot:XPO4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:XPO4_HUMAN
pepinfo	swissprot:XPO4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:XPO4_HUMAN
pepnet	swissprot:XPO4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:XPO4_HUMAN
pepstats	swissprot:XPO4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:XPO4_HUMAN
pepwheel	swissprot:XPO4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:XPO4_HUMAN
pepwindow	swissprot:XPO4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:XPO4_HUMAN
sigcleave	swissprot:XPO4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:XPO4_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TPC1_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9ULQ1-1; Sequence=Displayed; Name=2; IsoId=Q9ULQ1-2; Sequence=VSP_023003, VSP_023004, VSP_023005; Name=3; IsoId=Q9ULQ1-3; Sequence=VSP_041346; 
# AltName	TPC1_HUMAN	Voltage-dependent calcium channel protein TPC1
# BioGrid	119760	6
# CCDS	CCDS31908	-. [Q9ULQ1-1]
# CCDS	CCDS44985	-. [Q9ULQ1-3]
# ChiTaRS	TPCN1	human
# DOMAIN	TPC1_HUMAN	Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position (By similarity). {ECO 0000250}. 
# Ensembl	ENST00000335509	ENSP00000335300; ENSG00000186815. [Q9ULQ1-1]
# Ensembl	ENST00000541517	ENSP00000438125; ENSG00000186815. [Q9ULQ1-3]
# Ensembl	ENST00000550785	ENSP00000448083; ENSG00000186815. [Q9ULQ1-3]
# ExpressionAtlas	Q9ULQ1	baseline and differential
# FUNCTION	TPC1_HUMAN	Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane. {ECO 0000269|PubMed 19620632}. 
# GO_component	GO:0005764	lysosome; TAS:ParkinsonsUK-UCL.
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005768	endosome; TAS:ParkinsonsUK-UCL.
# GO_component	GO:0005886	plasma membrane; IBA:GO_Central.
# GO_component	GO:0010008	endosome membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005245	voltage-gated calcium channel activity; IBA:GO_Central.
# GO_function	GO:0072345	NAADP-sensitive calcium-release channel activity; IDA:UniProtKB.
# GO_process	GO:0010508	positive regulation of autophagy; IDA:ParkinsonsUK-UCL.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0086010	membrane depolarization during action potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005764	lysosome
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.120.350	-; 1.
# Genevisible	Q9ULQ1	HS
# HGNC	HGNC:18182	TPCN1
# INTERACTION	TPC1_HUMAN	Self; NbExp=3; IntAct=EBI-5239895, EBI-5239895; O00165 HAX1; NbExp=2; IntAct=EBI-5239895, EBI-357001; Q8NHX9 TPCN2; NbExp=9; IntAct=EBI-5239895, EBI-5239949; 
# IntAct	Q9ULQ1	3
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR027359	Channel_four-helix_dom
# MIM	609666	gene
# Organism	TPC1_HUMAN	Homo sapiens (Human)
# Pfam	PF00520	Ion_trans; 2
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	TPC1_HUMAN	Two pore calcium channel protein 1
# RefSeq	NP_001137291	NM_001143819.2. [Q9ULQ1-3]
# RefSeq	NP_001288143	NM_001301214.1
# RefSeq	NP_060371	NM_017901.5. [Q9ULQ1-1]
# RefSeq	XP_011536792	XM_011538490.2. [Q9ULQ1-3]
# RefSeq	XP_011536794	XM_011538492.2. [Q9ULQ1-1]
# SEQUENCE CAUTION	Sequence=AK057414; Type=Frameshift; Positions=273; Evidence={ECO:0000305}; Sequence=BAA86483.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	TPC1_HUMAN	Lysosome membrane {ECO 0000269|PubMed 19620632}; Multi-pass membrane protein {ECO 0000269|PubMed 19620632}. Endosome membrane {ECO 0000269|PubMed 19620632}; Multi-pass membrane protein {ECO 0000269|PubMed 19620632}. 
# SUBUNIT	Dimer. {ECO	0000305}. 
# TCDB	1.A.1.11.25	the voltage-gated ion channel (vic) superfamily
# TISSUE SPECIFICITY	Highest expression found in the heart and kidney, and lowest expression found in the spleen. {ECO:0000269|PubMed	10574461}. 
# UCSC	uc001tuw	human. [Q9ULQ1-1]
# eggNOG	ENOG410INF7	Eukaryota
# eggNOG	ENOG410XZT8	LUCA
BLAST	swissprot:TPC1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TPC1_HUMAN
BioCyc	ZFISH:G66-32950-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32950-MONOMER
COXPRESdb	53373	http://coxpresdb.jp/data/gene/53373.shtml
CleanEx	HS_TPCN1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TPCN1
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/nature04569	http://dx.doi.org/10.1038/nature04569
DOI	10.1038/nature08030	http://dx.doi.org/10.1038/nature08030
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1083/jcb.200904073	http://dx.doi.org/10.1083/jcb.200904073
DOI	10.1093/dnares/6.5.329	http://dx.doi.org/10.1093/dnares/6.5.329
DOI	10.1093/dnares/9.3.99	http://dx.doi.org/10.1093/dnares/9.3.99
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB032995	http://www.ebi.ac.uk/ena/data/view/AB032995
EMBL	AC010178	http://www.ebi.ac.uk/ena/data/view/AC010178
EMBL	AC089999	http://www.ebi.ac.uk/ena/data/view/AC089999
EMBL	AC127004	http://www.ebi.ac.uk/ena/data/view/AC127004
EMBL	AK057414	http://www.ebi.ac.uk/ena/data/view/AK057414
EMBL	AK075071	http://www.ebi.ac.uk/ena/data/view/AK075071
EMBL	AY083666	http://www.ebi.ac.uk/ena/data/view/AY083666
EMBL	BC136795	http://www.ebi.ac.uk/ena/data/view/BC136795
EMBL	BC136796	http://www.ebi.ac.uk/ena/data/view/BC136796
EMBL	BC150203	http://www.ebi.ac.uk/ena/data/view/BC150203
EMBL	BC152423	http://www.ebi.ac.uk/ena/data/view/BC152423
Ensembl	ENST00000335509	http://www.ensembl.org/id/ENST00000335509
Ensembl	ENST00000541517	http://www.ensembl.org/id/ENST00000541517
Ensembl	ENST00000550785	http://www.ensembl.org/id/ENST00000550785
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0010008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010008
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0072345	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072345
GO_process	GO:0010508	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010508
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0086010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086010
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005764	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005764
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	TPCN1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TPCN1
GeneID	53373	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=53373
GeneTree	ENSGT00530000063660	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063660
HGNC	HGNC:18182	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18182
HOGENOM	HOG000006773	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006773&db=HOGENOM6
HOVERGEN	HBG080605	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG080605&db=HOVERGEN
HPA	HPA039757	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA039757
InParanoid	Q9ULQ1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9ULQ1
IntAct	Q9ULQ1	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9ULQ1*
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
Jabion	53373	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=53373
KEGG_Gene	hsa:53373	http://www.genome.jp/dbget-bin/www_bget?hsa:53373
MIM	609666	http://www.ncbi.nlm.nih.gov/omim/609666
OMA	NVPWSYI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NVPWSYI
OrthoDB	EOG091G038K	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G038K
PSORT	swissprot:TPC1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TPC1_HUMAN
PSORT-B	swissprot:TPC1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TPC1_HUMAN
PSORT2	swissprot:TPC1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TPC1_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
PharmGKB	PA134922711	http://www.pharmgkb.org/do/serve?objId=PA134922711&objCls=Gene
Phobius	swissprot:TPC1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TPC1_HUMAN
PhylomeDB	Q9ULQ1	http://phylomedb.org/?seqid=Q9ULQ1
ProteinModelPortal	Q9ULQ1	http://www.proteinmodelportal.org/query/uniprot/Q9ULQ1
PubMed	10574461	http://www.ncbi.nlm.nih.gov/pubmed/10574461
PubMed	12168954	http://www.ncbi.nlm.nih.gov/pubmed/12168954
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16541075	http://www.ncbi.nlm.nih.gov/pubmed/16541075
PubMed	19387438	http://www.ncbi.nlm.nih.gov/pubmed/19387438
PubMed	19620632	http://www.ncbi.nlm.nih.gov/pubmed/19620632
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_001137291	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001137291
RefSeq	NP_001288143	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001288143
RefSeq	NP_060371	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060371
RefSeq	XP_011536792	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011536792
RefSeq	XP_011536794	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011536794
STRING	9606.ENSP00000438125	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000438125&targetmode=cogs
TCDB	1.A.1.11.25	http://www.tcdb.org/search/result.php?tc=1.A.1.11.25
UCSC	uc001tuw	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001tuw&org=rat
UniGene	Hs.524763	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.524763
UniProtKB	TPC1_HUMAN	http://www.uniprot.org/uniprot/TPC1_HUMAN
UniProtKB-AC	Q9ULQ1	http://www.uniprot.org/uniprot/Q9ULQ1
charge	swissprot:TPC1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TPC1_HUMAN
eggNOG	ENOG410INF7	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410INF7
eggNOG	ENOG410XZT8	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XZT8
epestfind	swissprot:TPC1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TPC1_HUMAN
garnier	swissprot:TPC1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TPC1_HUMAN
helixturnhelix	swissprot:TPC1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TPC1_HUMAN
hmoment	swissprot:TPC1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TPC1_HUMAN
iep	swissprot:TPC1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TPC1_HUMAN
inforesidue	swissprot:TPC1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TPC1_HUMAN
neXtProt	NX_Q9ULQ1	http://www.nextprot.org/db/entry/NX_Q9ULQ1
octanol	swissprot:TPC1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TPC1_HUMAN
pepcoil	swissprot:TPC1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TPC1_HUMAN
pepdigest	swissprot:TPC1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TPC1_HUMAN
pepinfo	swissprot:TPC1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TPC1_HUMAN
pepnet	swissprot:TPC1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TPC1_HUMAN
pepstats	swissprot:TPC1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TPC1_HUMAN
pepwheel	swissprot:TPC1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TPC1_HUMAN
pepwindow	swissprot:TPC1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TPC1_HUMAN
sigcleave	swissprot:TPC1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TPC1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S29A2_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Long; IsoId=Q14542-1; Sequence=Displayed; Name=2; Synonyms=Short, HNP36; IsoId=Q14542-2; Sequence=VSP_040728, VSP_040729; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; IsoId=Q14542-3; Sequence=VSP_040730, VSP_040731; 
# AltName	S29A2_HUMAN	36 kDa nucleolar protein HNP36
# AltName	S29A2_HUMAN	Delayed-early response protein 12
# AltName	S29A2_HUMAN	Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter
# AltName	S29A2_HUMAN	Hydrophobic nucleolar protein, 36 kDa
# AltName	S29A2_HUMAN	Nucleoside transporter, ei-type
# AltName	S29A2_HUMAN	Solute carrier family 29 member 2
# BIOPHYSICOCHEMICAL PROPERTIES	S29A2_HUMAN	Kinetic parameters  KM=0.2 mM for uridine {ECO 0000269|PubMed 12527552, ECO 0000269|PubMed 9396714}; KM=0.75 mM for adenosine {ECO 0000269|PubMed 12527552, ECO 0000269|PubMed 9396714}; Note=Vmax for adenosine uptake is about the same for SLC29A1 and SLC29A2.; 
# BioGrid	109419	2
# CCDS	CCDS8137	-. [Q14542-1]
# DrugBank	DB00441	Gemcitabine
# DrugBank	DB00495	Zidovudine
# DrugBank	DB00898	Ethanol
# DrugBank	DB00900	Didanosine
# DrugBank	DB00943	Zalcitabine
# DrugBank	DB01033	Mercaptopurine
# Ensembl	ENST00000357440	ENSP00000350024; ENSG00000174669. [Q14542-1]
# Ensembl	ENST00000540386	ENSP00000444870; ENSG00000174669. [Q14542-3]
# Ensembl	ENST00000541567	ENSP00000442116; ENSG00000174669. [Q14542-2]
# Ensembl	ENST00000544554	ENSP00000439456; ENSG00000174669. [Q14542-1]
# Ensembl	ENST00000546034	ENSP00000440329; ENSG00000174669. [Q14542-1]
# ExpressionAtlas	Q14542	baseline and differential
# FUNCTION	S29A2_HUMAN	Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine. {ECO 0000269|PubMed 9396714}. 
# GO_component	GO:0005730	nucleolus; TAS:ProtInc.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0016323	basolateral plasma membrane; IDA:UniProtKB.
# GO_component	GO:0031965	nuclear membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0005337	nucleoside transmembrane transporter activity; TAS:Reactome.
# GO_process	GO:0006139	nucleobase-containing compound metabolic process; TAS:ProtInc.
# GO_process	GO:0008283	cell proliferation; TAS:ProtInc.
# GO_process	GO:0015858	nucleoside transport; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005730	nucleolus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008283	cell proliferation
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# Genevisible	Q14542	HS
# HGNC	HGNC:11004	SLC29A2
# INDUCTION	S29A2_HUMAN	By PDGF/platelet derived growth factor and fibroblast growth factor (FGF). 
# InterPro	IPR002259	Eqnu_transpt
# InterPro	IPR020846	MFS_dom
# InterPro	IPR030197	ENT2
# KEGG_Brite	ko02001	Solute carrier family
# MIM	602110	gene
# Organism	S29A2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10332	PTHR10332; 2
# PANTHER	PTHR10332:SF8	PTHR10332:SF8; 2
# PIR	JC4196	JC4196
# PIRSF	PIRSF016379	ENT
# PRINTS	PR01130	DERENTRNSPRT
# Pfam	PF01733	Nucleoside_tran
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-83936	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
# RecName	S29A2_HUMAN	Equilibrative nucleoside transporter 2
# RefSeq	NP_001287797	NM_001300868.1. [Q14542-1]
# RefSeq	NP_001523	NM_001532.2. [Q14542-1]
# RefSeq	XP_016873121	XM_017017632.1. [Q14542-1]
# SEQUENCE CAUTION	Sequence=CAA60380.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the SLC29A/ENT transporter (TC 2.A.57) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S29A2_HUMAN	Basolateral cell membrane {ECO 0000269|PubMed 12527552}; Multi-pass membrane protein {ECO 0000269|PubMed 12527552}. Nucleus membrane {ECO 0000269|PubMed 12527552}; Multi-pass membrane protein {ECO 0000269|PubMed 12527552}. Note=Localized at the basolateral cell membrane in polarized MDCK cells. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.57.1	the equilibrative nucleoside transporter (ent) family
# TIGRFAMs	TIGR00939	2a57
# TISSUE SPECIFICITY	S29A2_HUMAN	Expressed in skeletal muscle, liver, lung, placenta, brain, heart, kidney and ovarian tissues. {ECO 0000269|PubMed 12527552, ECO 0000269|PubMed 9396714}. 
# UCSC	uc001oht	human. [Q14542-1]
# eggNOG	ENOG410Y3MT	LUCA
# eggNOG	KOG1479	Eukaryota
BLAST	swissprot:S29A2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S29A2_HUMAN
BioCyc	ZFISH:ENSG00000174669-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000174669-MONOMER
COXPRESdb	3177	http://coxpresdb.jp/data/gene/3177.shtml
CleanEx	HS_SLC29A2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC29A2
DOI	10.1006/bbrc.1995.2133	http://dx.doi.org/10.1006/bbrc.1995.2133
DOI	10.1016/S0003-9861(02)00718-X	http://dx.doi.org/10.1016/S0003-9861(02)00718-X
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/bj3280739	http://dx.doi.org/10.1042/bj3280739
DOI	10.1074/jbc.273.9.5288	http://dx.doi.org/10.1074/jbc.273.9.5288
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1124/dmd.105.006270	http://dx.doi.org/10.1124/dmd.105.006270
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DrugBank	DB00441	http://www.drugbank.ca/drugs/DB00441
DrugBank	DB00495	http://www.drugbank.ca/drugs/DB00495
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB00900	http://www.drugbank.ca/drugs/DB00900
DrugBank	DB00943	http://www.drugbank.ca/drugs/DB00943
DrugBank	DB01033	http://www.drugbank.ca/drugs/DB01033
EMBL	AF029358	http://www.ebi.ac.uk/ena/data/view/AF029358
EMBL	AF034102	http://www.ebi.ac.uk/ena/data/view/AF034102
EMBL	AF401235	http://www.ebi.ac.uk/ena/data/view/AF401235
EMBL	AK057041	http://www.ebi.ac.uk/ena/data/view/AK057041
EMBL	AP001107	http://www.ebi.ac.uk/ena/data/view/AP001107
EMBL	BC093634	http://www.ebi.ac.uk/ena/data/view/BC093634
EMBL	CH471076	http://www.ebi.ac.uk/ena/data/view/CH471076
EMBL	CH471076	http://www.ebi.ac.uk/ena/data/view/CH471076
EMBL	X86681	http://www.ebi.ac.uk/ena/data/view/X86681
Ensembl	ENST00000357440	http://www.ensembl.org/id/ENST00000357440
Ensembl	ENST00000540386	http://www.ensembl.org/id/ENST00000540386
Ensembl	ENST00000541567	http://www.ensembl.org/id/ENST00000541567
Ensembl	ENST00000544554	http://www.ensembl.org/id/ENST00000544554
Ensembl	ENST00000546034	http://www.ensembl.org/id/ENST00000546034
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005730
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0016323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016323
GO_component	GO:0031965	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031965
GO_function	GO:0005337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005337
GO_process	GO:0006139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006139
GO_process	GO:0008283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008283
GO_process	GO:0015858	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015858
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005730
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008283
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GeneCards	SLC29A2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC29A2
GeneID	3177	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3177
GeneTree	ENSGT00390000002232	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002232
HGNC	HGNC:11004	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11004
HOGENOM	HOG000007684	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007684&db=HOGENOM6
HOVERGEN	HBG074626	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG074626&db=HOVERGEN
HPA	HPA018168	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA018168
InParanoid	Q14542	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q14542
IntAct	Q14542	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q14542*
InterPro	IPR002259	http://www.ebi.ac.uk/interpro/entry/IPR002259
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
InterPro	IPR030197	http://www.ebi.ac.uk/interpro/entry/IPR030197
Jabion	3177	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3177
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:3177	http://www.genome.jp/dbget-bin/www_bget?hsa:3177
KEGG_Orthology	KO:K15014	http://www.genome.jp/dbget-bin/www_bget?KO:K15014
MIM	602110	http://www.ncbi.nlm.nih.gov/omim/602110
OMA	FNIMDCL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FNIMDCL
OrthoDB	EOG091G09WB	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G09WB
PANTHER	PTHR10332	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10332
PANTHER	PTHR10332:SF8	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10332:SF8
PRINTS	PR01130	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01130
PSORT	swissprot:S29A2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S29A2_HUMAN
PSORT-B	swissprot:S29A2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S29A2_HUMAN
PSORT2	swissprot:S29A2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S29A2_HUMAN
Pfam	PF01733	http://pfam.xfam.org/family/PF01733
PharmGKB	PA191	http://www.pharmgkb.org/do/serve?objId=PA191&objCls=Gene
Phobius	swissprot:S29A2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S29A2_HUMAN
PhylomeDB	Q14542	http://phylomedb.org/?seqid=Q14542
ProteinModelPortal	Q14542	http://www.proteinmodelportal.org/query/uniprot/Q14542
PubMed	12527552	http://www.ncbi.nlm.nih.gov/pubmed/12527552
PubMed	12590919	http://www.ncbi.nlm.nih.gov/pubmed/12590919
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16214850	http://www.ncbi.nlm.nih.gov/pubmed/16214850
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	7639753	http://www.ncbi.nlm.nih.gov/pubmed/7639753
PubMed	9396714	http://www.ncbi.nlm.nih.gov/pubmed/9396714
PubMed	9478986	http://www.ncbi.nlm.nih.gov/pubmed/9478986
Reactome	R-HSA-83936	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-83936
RefSeq	NP_001287797	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001287797
RefSeq	NP_001523	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001523
RefSeq	XP_016873121	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016873121
STRING	9606.ENSP00000350024	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000350024&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.57.1	http://www.tcdb.org/search/result.php?tc=2.A.57.1
TIGRFAMs	TIGR00939	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00939
UCSC	uc001oht	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001oht&org=rat
UniGene	Hs.569017	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.569017
UniGene	Hs.736345	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.736345
UniProtKB	S29A2_HUMAN	http://www.uniprot.org/uniprot/S29A2_HUMAN
UniProtKB-AC	Q14542	http://www.uniprot.org/uniprot/Q14542
charge	swissprot:S29A2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S29A2_HUMAN
eggNOG	ENOG410Y3MT	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y3MT
eggNOG	KOG1479	http://eggnogapi.embl.de/nog_data/html/tree/KOG1479
epestfind	swissprot:S29A2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S29A2_HUMAN
garnier	swissprot:S29A2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S29A2_HUMAN
helixturnhelix	swissprot:S29A2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S29A2_HUMAN
hmoment	swissprot:S29A2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S29A2_HUMAN
iep	swissprot:S29A2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S29A2_HUMAN
inforesidue	swissprot:S29A2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S29A2_HUMAN
neXtProt	NX_Q14542	http://www.nextprot.org/db/entry/NX_Q14542
octanol	swissprot:S29A2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S29A2_HUMAN
pepcoil	swissprot:S29A2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S29A2_HUMAN
pepdigest	swissprot:S29A2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S29A2_HUMAN
pepinfo	swissprot:S29A2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S29A2_HUMAN
pepnet	swissprot:S29A2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S29A2_HUMAN
pepstats	swissprot:S29A2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S29A2_HUMAN
pepwheel	swissprot:S29A2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S29A2_HUMAN
pepwindow	swissprot:S29A2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S29A2_HUMAN
sigcleave	swissprot:S29A2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S29A2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	TCPW_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q92526-1; Sequence=Displayed; Name=2; IsoId=Q92526-2; Sequence=VSP_043040; Note=No experimental confirmation available.; Name=3; IsoId=Q92526-3; Sequence=VSP_047129; 
# AltName	TCPW_HUMAN	CCT-zeta-2
# AltName	TCPW_HUMAN	CCT-zeta-like
# AltName	TCPW_HUMAN	TCP-1-zeta-like
# AltName	TCPW_HUMAN	Testis-specific Tcp20
# AltName	TCPW_HUMAN	Testis-specific protein TSA303
# BioGrid	115932	106
# CCDS	CCDS32617	-. [Q92526-1]
# CCDS	CCDS54105	-. [Q92526-2]
# CCDS	CCDS54106	-. [Q92526-3]
# CDD	cd03342	TCP1_zeta
# Ensembl	ENST00000314144	ENSP00000327191; ENSG00000132141. [Q92526-1]
# Ensembl	ENST00000421975	ENSP00000398044; ENSG00000132141. [Q92526-3]
# Ensembl	ENST00000436961	ENSP00000400917; ENSG00000132141. [Q92526-2]
# ExpressionAtlas	Q92526	baseline and differential
# FUNCTION	TCPW_HUMAN	Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity). {ECO 0000250}. 
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0005832	chaperonin-containing T-complex; IEA:Ensembl.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0008565	protein transporter activity; TAS:ProtInc.
# GO_function	GO:0051082	unfolded protein binding; TAS:ProtInc.
# GO_process	GO:0006457	protein folding; TAS:ProtInc.
# GO_process	GO:0007283	spermatogenesis; TAS:ProtInc.
# GO_process	GO:0051131	chaperone-mediated protein complex assembly; TAS:ProtInc.
# GO_process	GO:1901998	toxin transport; IEA:Ensembl.
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_function	GO:0051082	unfolded protein binding
# GOslim_process	GO:0006457	protein folding
# GOslim_process	GO:0006461	protein complex assembly
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.10.560.10	-; 2.
# Gene3D	3.30.260.10	-; 2.
# Gene3D	3.50.7.10	-; 1.
# Genevisible	Q92526	HS
# HGNC	HGNC:1621	CCT6B
# IntAct	Q92526	6
# InterPro	IPR002194	Chaperonin_TCP-1_CS
# InterPro	IPR002423	Cpn60/TCP-1
# InterPro	IPR012722	Chap_CCT_zeta
# InterPro	IPR017998	Chaperone_TCP-1
# InterPro	IPR027409	GroEL-like_apical_dom
# InterPro	IPR027410	TCP-1-like_intermed
# InterPro	IPR027413	GROEL-like_equatorial
# KEGG_Brite	ko03110	Chaperones and folding catalysts
# MIM	610730	gene
# Organism	TCPW_HUMAN	Homo sapiens (Human)
# PRINTS	PR00304	TCOMPLEXTCP1
# PROSITE	PS00750	TCP1_1
# PROSITE	PS00751	TCP1_2
# PROSITE	PS00995	TCP1_3
# Pfam	PF00118	Cpn60_TCP1
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-389957	Prefoldin mediated transfer of substrate to CCT/TriC
# Reactome	R-HSA-389960	Formation of tubulin folding intermediates by CCT/TriC
# Reactome	R-HSA-390450	Folding of actin by CCT/TriC
# Reactome	R-HSA-390471	Association of TriC/CCT with target proteins during biosynthesis
# Reactome	R-HSA-6814122	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
# RecName	TCPW_HUMAN	T-complex protein 1 subunit zeta-2
# RefSeq	NP_001180458	NM_001193529.2. [Q92526-3]
# RefSeq	NP_001180459	NM_001193530.1. [Q92526-2]
# RefSeq	NP_006575	NM_006584.3. [Q92526-1]
# SIMILARITY	Belongs to the TCP-1 chaperonin family. {ECO	0000305}.
# SUBCELLULAR LOCATION	TCPW_HUMAN	Cytoplasm. 
# SUBUNIT	TCPW_HUMAN	Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. 
# SUPFAM	SSF52029	SSF52029
# TIGRFAMs	TIGR02347	chap_CCT_zeta
# TISSUE SPECIFICITY	TCPW_HUMAN	Testis specific. 
# UCSC	uc002hig	human. [Q92526-1]
# eggNOG	ENOG410XQ3Q	LUCA
# eggNOG	KOG0359	Eukaryota
BLAST	swissprot:TCPW_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TCPW_HUMAN
BioCyc	ZFISH:ENSG00000132141-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000132141-MONOMER
COXPRESdb	10693	http://coxpresdb.jp/data/gene/10693.shtml
CleanEx	HS_CCT6B	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CCT6B
DIP	DIP-53269N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-53269N
DOI	10.1006/geno.1996.0467	http://dx.doi.org/10.1006/geno.1996.0467
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AC022903	http://www.ebi.ac.uk/ena/data/view/AC022903
EMBL	AK301773	http://www.ebi.ac.uk/ena/data/view/AK301773
EMBL	AK302344	http://www.ebi.ac.uk/ena/data/view/AK302344
EMBL	BC026125	http://www.ebi.ac.uk/ena/data/view/BC026125
EMBL	BC027591	http://www.ebi.ac.uk/ena/data/view/BC027591
EMBL	D78333	http://www.ebi.ac.uk/ena/data/view/D78333
Ensembl	ENST00000314144	http://www.ensembl.org/id/ENST00000314144
Ensembl	ENST00000421975	http://www.ensembl.org/id/ENST00000421975
Ensembl	ENST00000436961	http://www.ensembl.org/id/ENST00000436961
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005832	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005832
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_function	GO:0051082	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051082
GO_process	GO:0006457	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457
GO_process	GO:0007283	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007283
GO_process	GO:0051131	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051131
GO_process	GO:1901998	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901998
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_function	GO:0051082	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051082
GOslim_process	GO:0006457	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457
GOslim_process	GO:0006461	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.10.560.10	http://www.cathdb.info/version/latest/superfamily/1.10.560.10
Gene3D	3.30.260.10	http://www.cathdb.info/version/latest/superfamily/3.30.260.10
Gene3D	3.50.7.10	http://www.cathdb.info/version/latest/superfamily/3.50.7.10
GeneCards	CCT6B	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCT6B
GeneID	10693	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10693
GeneTree	ENSGT00550000074743	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074743
H-InvDB	HIX0013717	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0013717
HGNC	HGNC:1621	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1621
HOGENOM	HOG000226733	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000226733&db=HOGENOM6
HOVERGEN	HBG103725	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG103725&db=HOVERGEN
HPA	HPA042996	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042996
HPA	HPA045576	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA045576
HPA	HPA049949	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA049949
InParanoid	Q92526	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q92526
IntAct	Q92526	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q92526*
InterPro	IPR002194	http://www.ebi.ac.uk/interpro/entry/IPR002194
InterPro	IPR002423	http://www.ebi.ac.uk/interpro/entry/IPR002423
InterPro	IPR012722	http://www.ebi.ac.uk/interpro/entry/IPR012722
InterPro	IPR017998	http://www.ebi.ac.uk/interpro/entry/IPR017998
InterPro	IPR027409	http://www.ebi.ac.uk/interpro/entry/IPR027409
InterPro	IPR027410	http://www.ebi.ac.uk/interpro/entry/IPR027410
InterPro	IPR027413	http://www.ebi.ac.uk/interpro/entry/IPR027413
Jabion	10693	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10693
KEGG_Brite	ko03110	http://www.genome.jp/dbget-bin/www_bget?ko03110
KEGG_Gene	hsa:10693	http://www.genome.jp/dbget-bin/www_bget?hsa:10693
KEGG_Orthology	KO:K09498	http://www.genome.jp/dbget-bin/www_bget?KO:K09498
MIM	610730	http://www.ncbi.nlm.nih.gov/omim/610730
OMA	IVEMKHK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IVEMKHK
OrthoDB	EOG091G07CE	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G07CE
PRINTS	PR00304	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00304
PROSITE	PS00750	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00750
PROSITE	PS00751	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00751
PROSITE	PS00995	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00995
PSORT	swissprot:TCPW_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TCPW_HUMAN
PSORT-B	swissprot:TCPW_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TCPW_HUMAN
PSORT2	swissprot:TCPW_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TCPW_HUMAN
Pfam	PF00118	http://pfam.xfam.org/family/PF00118
PharmGKB	PA26184	http://www.pharmgkb.org/do/serve?objId=PA26184&objCls=Gene
Phobius	swissprot:TCPW_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TCPW_HUMAN
PhylomeDB	Q92526	http://phylomedb.org/?seqid=Q92526
ProteinModelPortal	Q92526	http://www.proteinmodelportal.org/query/uniprot/Q92526
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	8812458	http://www.ncbi.nlm.nih.gov/pubmed/8812458
Reactome	R-HSA-389957	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-389957
Reactome	R-HSA-389960	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-389960
Reactome	R-HSA-390450	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-390450
Reactome	R-HSA-390471	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-390471
Reactome	R-HSA-6814122	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6814122
RefSeq	NP_001180458	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001180458
RefSeq	NP_001180459	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001180459
RefSeq	NP_006575	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006575
STRING	9606.ENSP00000327191	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000327191&targetmode=cogs
SUPFAM	SSF52029	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52029
TIGRFAMs	TIGR02347	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02347
UCSC	uc002hig	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002hig&org=rat
UniGene	Hs.73072	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.73072
UniProtKB	TCPW_HUMAN	http://www.uniprot.org/uniprot/TCPW_HUMAN
UniProtKB-AC	Q92526	http://www.uniprot.org/uniprot/Q92526
charge	swissprot:TCPW_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TCPW_HUMAN
eggNOG	ENOG410XQ3Q	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ3Q
eggNOG	KOG0359	http://eggnogapi.embl.de/nog_data/html/tree/KOG0359
epestfind	swissprot:TCPW_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TCPW_HUMAN
garnier	swissprot:TCPW_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TCPW_HUMAN
helixturnhelix	swissprot:TCPW_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TCPW_HUMAN
hmoment	swissprot:TCPW_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TCPW_HUMAN
iep	swissprot:TCPW_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TCPW_HUMAN
inforesidue	swissprot:TCPW_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TCPW_HUMAN
neXtProt	NX_Q92526	http://www.nextprot.org/db/entry/NX_Q92526
octanol	swissprot:TCPW_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TCPW_HUMAN
pepcoil	swissprot:TCPW_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TCPW_HUMAN
pepdigest	swissprot:TCPW_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TCPW_HUMAN
pepinfo	swissprot:TCPW_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TCPW_HUMAN
pepnet	swissprot:TCPW_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TCPW_HUMAN
pepstats	swissprot:TCPW_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TCPW_HUMAN
pepwheel	swissprot:TCPW_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TCPW_HUMAN
pepwindow	swissprot:TCPW_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TCPW_HUMAN
sigcleave	swissprot:TCPW_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TCPW_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	115876	60
# ChiTaRS	ATP5L	human
# Ensembl	ENST00000300688	ENSP00000300688; ENSG00000167283
# ExpressionAtlas	O75964	baseline and differential
# FUNCTION	ATP5L_HUMAN	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. 
# GO_component	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); IBA:GO_Central.
# GO_component	GO:0005739	mitochondrion; IDA:LIFEdb.
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0005753	mitochondrial proton-transporting ATP synthase complex; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0015078	hydrogen ion transmembrane transporter activity; IEA:InterPro.
# GO_function	GO:0022857	transmembrane transporter activity; IC:UniProtKB.
# GO_process	GO:0006754	ATP biosynthetic process; TAS:Reactome.
# GO_process	GO:0015986	ATP synthesis coupled proton transport; IBA:GO_Central.
# GO_process	GO:0042776	mitochondrial ATP synthesis coupled proton transport; IC:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	O75964	HS
# HGNC	HGNC:14247	ATP5L
# IntAct	O75964	21
# InterPro	IPR006808	ATP_synth_F0_gsu_mt
# InterPro	IPR016702	ATP_synth_su_G_mt_met
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# Organism	ATP5L_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12386	PTHR12386
# PIR	T08727	T08727
# PIRSF	PIRSF017835	ATP-synth_g_mitoch_animal
# Pfam	PF04718	ATP-synt_G
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-163210	Formation of ATP by chemiosmotic coupling
# RecName	ATP5L_HUMAN	ATP synthase subunit g, mitochondrial
# RefSeq	NP_006467	NM_006476.4
# SIMILARITY	Belongs to the ATPase g subunit family. {ECO	0000305}.
# SUBCELLULAR LOCATION	ATP5L_HUMAN	Mitochondrion. Mitochondrion inner membrane. 
# SUBUNIT	F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity). {ECO	0000250}. 
# UCSC	uc001psx	human
# eggNOG	ENOG4111TZ1	LUCA
# eggNOG	KOG4103	Eukaryota
BLAST	swissprot:ATP5L_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ATP5L_HUMAN
BioCyc	ZFISH:HS09535-MONOMER	http://biocyc.org/getid?id=ZFISH:HS09535-MONOMER
COXPRESdb	10632	http://coxpresdb.jp/data/gene/10632.shtml
CleanEx	HS_ATP5L	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP5L
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.140200	http://dx.doi.org/10.1101/gr.140200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1101/gr.GR1547R	http://dx.doi.org/10.1101/gr.GR1547R
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF070655	http://www.ebi.ac.uk/ena/data/view/AF070655
EMBL	AF087846	http://www.ebi.ac.uk/ena/data/view/AF087846
EMBL	AF092124	http://www.ebi.ac.uk/ena/data/view/AF092124
EMBL	AK289568	http://www.ebi.ac.uk/ena/data/view/AK289568
EMBL	AL050277	http://www.ebi.ac.uk/ena/data/view/AL050277
EMBL	BC015128	http://www.ebi.ac.uk/ena/data/view/BC015128
EMBL	BC070165	http://www.ebi.ac.uk/ena/data/view/BC070165
EMBL	CH471065	http://www.ebi.ac.uk/ena/data/view/CH471065
EMBL	CR533494	http://www.ebi.ac.uk/ena/data/view/CR533494
EMBL	CR542211	http://www.ebi.ac.uk/ena/data/view/CR542211
Ensembl	ENST00000300688	http://www.ensembl.org/id/ENST00000300688
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000276	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000276
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005753	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005753
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0015078	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015078
GO_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GO_process	GO:0006754	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006754
GO_process	GO:0015986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015986
GO_process	GO:0042776	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042776
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ATP5L	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP5L
GeneID	10632	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10632
GeneTree	ENSGT00390000009724	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000009724
HGNC	HGNC:14247	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:14247
HOGENOM	HOG000007506	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007506&db=HOGENOM6
HOVERGEN	HBG050614	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050614&db=HOVERGEN
HPA	HPA044629	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA044629
InParanoid	O75964	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O75964
IntAct	O75964	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O75964*
InterPro	IPR006808	http://www.ebi.ac.uk/interpro/entry/IPR006808
InterPro	IPR016702	http://www.ebi.ac.uk/interpro/entry/IPR016702
Jabion	10632	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10632
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:10632	http://www.genome.jp/dbget-bin/www_bget?hsa:10632
KEGG_Orthology	KO:K02140	http://www.genome.jp/dbget-bin/www_bget?KO:K02140
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
MINT	MINT-3002124	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3002124
OMA	WQYAKVE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WQYAKVE
OrthoDB	EOG091G16ZZ	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G16ZZ
PANTHER	PTHR12386	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12386
PSORT	swissprot:ATP5L_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ATP5L_HUMAN
PSORT-B	swissprot:ATP5L_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ATP5L_HUMAN
PSORT2	swissprot:ATP5L_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ATP5L_HUMAN
Pfam	PF04718	http://pfam.xfam.org/family/PF04718
PharmGKB	PA25143	http://www.pharmgkb.org/do/serve?objId=PA25143&objCls=Gene
Phobius	swissprot:ATP5L_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ATP5L_HUMAN
PhylomeDB	O75964	http://phylomedb.org/?seqid=O75964
ProteinModelPortal	O75964	http://www.proteinmodelportal.org/query/uniprot/O75964
PubMed	11042152	http://www.ncbi.nlm.nih.gov/pubmed/11042152
PubMed	11230166	http://www.ncbi.nlm.nih.gov/pubmed/11230166
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-163210	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-163210
RefSeq	NP_006467	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006467
STRING	9606.ENSP00000300688	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000300688&targetmode=cogs
UCSC	uc001psx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001psx&org=rat
UniGene	Hs.486360	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.486360
UniProtKB	ATP5L_HUMAN	http://www.uniprot.org/uniprot/ATP5L_HUMAN
UniProtKB-AC	O75964	http://www.uniprot.org/uniprot/O75964
charge	swissprot:ATP5L_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ATP5L_HUMAN
eggNOG	ENOG4111TZ1	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111TZ1
eggNOG	KOG4103	http://eggnogapi.embl.de/nog_data/html/tree/KOG4103
epestfind	swissprot:ATP5L_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ATP5L_HUMAN
garnier	swissprot:ATP5L_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ATP5L_HUMAN
helixturnhelix	swissprot:ATP5L_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATP5L_HUMAN
hmoment	swissprot:ATP5L_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ATP5L_HUMAN
iep	swissprot:ATP5L_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ATP5L_HUMAN
inforesidue	swissprot:ATP5L_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ATP5L_HUMAN
neXtProt	NX_O75964	http://www.nextprot.org/db/entry/NX_O75964
octanol	swissprot:ATP5L_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ATP5L_HUMAN
pepcoil	swissprot:ATP5L_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ATP5L_HUMAN
pepdigest	swissprot:ATP5L_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ATP5L_HUMAN
pepinfo	swissprot:ATP5L_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ATP5L_HUMAN
pepnet	swissprot:ATP5L_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ATP5L_HUMAN
pepstats	swissprot:ATP5L_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ATP5L_HUMAN
pepwheel	swissprot:ATP5L_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ATP5L_HUMAN
pepwindow	swissprot:ATP5L_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ATP5L_HUMAN
sigcleave	swissprot:ATP5L_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ATP5L_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	B2LA1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q16548-1; Sequence=Displayed; Name=2; IsoId=Q16548-2; Sequence=VSP_043106; 
# AltName	B2LA1_HUMAN	Bcl-2-like protein 5
# AltName	B2LA1_HUMAN	Hemopoietic-specific early response protein
# AltName	B2LA1_HUMAN	Protein BFL-1
# AltName	B2LA1_HUMAN	Protein GRS
# BioGrid	107069	16
# CCDS	CCDS10312	-. [Q16548-1]
# CCDS	CCDS45322	-. [Q16548-2]
# ChiTaRS	BCL2A1	human
# Ensembl	ENST00000267953	ENSP00000267953; ENSG00000140379. [Q16548-1]
# Ensembl	ENST00000335661	ENSP00000335250; ENSG00000140379. [Q16548-2]
# FUNCTION	B2LA1_HUMAN	Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity). Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11 (By similarity). {ECO 0000250, ECO 0000250|UniProtKB Q07440}. 
# GO_component	GO:0005741	mitochondrial outer membrane; IBA:GO_Central.
# GO_function	GO:0015267	channel activity; IBA:GO_Central.
# GO_function	GO:0042803	protein homodimerization activity; IBA:GO_Central.
# GO_function	GO:0046982	protein heterodimerization activity; IBA:GO_Central.
# GO_process	GO:0001836	release of cytochrome c from mitochondria; IBA:GO_Central.
# GO_process	GO:0007568	aging; IEA:Ensembl.
# GO_process	GO:0008053	mitochondrial fusion; IBA:GO_Central.
# GO_process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage; IBA:GO_Central.
# GO_process	GO:0021987	cerebral cortex development; IEA:Ensembl.
# GO_process	GO:0043065	positive regulation of apoptotic process; IBA:GO_Central.
# GO_process	GO:0043066	negative regulation of apoptotic process; ISS:UniProtKB.
# GO_process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007005	mitochondrion organization
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007568	aging
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0061024	membrane organization
# Genevisible	Q16548	HS
# HGNC	HGNC:991	BCL2A1
# INDUCTION	B2LA1_HUMAN	By phorbol ester and inflammatory cytokines, such as TNF or IL1B/interleukin-1 beta, but not by growth factors. 
# INTERACTION	B2LA1_HUMAN	Q16611 BAK1; NbExp=5; IntAct=EBI-1003550, EBI-519866; Q13323 BIK; NbExp=5; IntAct=EBI-1003550, EBI-700794; Q8IZU0 FAM9B; NbExp=3; IntAct=EBI-1003550, EBI-10175124; 
# IntAct	Q16548	10
# InterPro	IPR002475	Bcl2-like
# InterPro	IPR013282	Bcl2A1
# InterPro	IPR020717	Bcl2_BH1_motif_CS
# InterPro	IPR020726	Bcl2_BH2_motif_CS
# InterPro	IPR026298	Blc2_fam
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Pathway	ko04064	NF-kappa B signaling pathway
# KEGG_Pathway	ko05202	Transcriptional misregulation in cancer
# MIM	601056	gene
# Organism	B2LA1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11256	PTHR11256
# PANTHER	PTHR11256:SF10	PTHR11256:SF10
# PDB	2VM6	X-ray; 2.20 A; A=1-149
# PDB	3I1H	X-ray; 2.20 A; A=1-151
# PDB	3MQP	X-ray; 2.24 A; A=1-151
# PDB	4ZEQ	X-ray; 1.80 A; A=1-151
# PIR	I39055	I39055
# PRINTS	PR01862	BCL2FAMILY
# PRINTS	PR01867	BCL2RLATEDA1
# PROSITE	PS01080	BH1
# PROSITE	PS01258	BH2
# PROSITE	PS50062	BCL2_FAMILY
# Pfam	PF00452	Bcl-2
# Proteomes	UP000005640	Chromosome 15
# RecName	B2LA1_HUMAN	Bcl-2-related protein A1
# RefSeq	NP_001108207	NM_001114735.1. [Q16548-2]
# RefSeq	NP_004040	NM_004049.3. [Q16548-1]
# SIMILARITY	Belongs to the Bcl-2 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	B2LA1_HUMAN	Cytoplasm. 
# SUBUNIT	B2LA1_HUMAN	Interacts directly with BAK1, BID, BMF and BBC3 (By similarity). Interacts directly with BCL2L11/BIM. Interacts with BAX isoform Sigma. Interacts directly with PMAIP1. Interacts with BOP/C22orf29. Interacts with ING4 (By similarity). {ECO 0000250|UniProtKB Q07440, ECO 0000269|PubMed 10772918, ECO 0000269|PubMed 18812174, ECO 0000269|PubMed 23055042, ECO 0000269|Ref.13, ECO 0000269|Ref.14}. 
# TISSUE SPECIFICITY	B2LA1_HUMAN	Seems to be restricted to the hematopoietic compartment. Expressed in peripheral blood, spleen, and bone marrow, at moderate levels in lung, small intestine and testis, at a minimal levels in other tissues. Also found in vascular smooth muscle cells and hematopoietic malignancies. 
# UCSC	uc002bfc	human. [Q16548-1]
# eggNOG	ENOG41123S0	LUCA
# eggNOG	KOG4728	Eukaryota
BLAST	swissprot:B2LA1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:B2LA1_HUMAN
BioCyc	ZFISH:ENSG00000140379-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000140379-MONOMER
COXPRESdb	597	http://coxpresdb.jp/data/gene/597.shtml
CleanEx	HS_BCL2A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_BCL2A1
DOI	10.1006/bbrc.2000.2537	http://dx.doi.org/10.1006/bbrc.2000.2537
DOI	10.1007/s13238-012-2069-7	http://dx.doi.org/10.1007/s13238-012-2069-7
DOI	10.1016/j.febslet.2008.09.028	http://dx.doi.org/10.1016/j.febslet.2008.09.028
DOI	10.1038/nature04601	http://dx.doi.org/10.1038/nature04601
DOI	10.1038/sj.onc.1200898	http://dx.doi.org/10.1038/sj.onc.1200898
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC015871	http://www.ebi.ac.uk/ena/data/view/AC015871
EMBL	AY234180	http://www.ebi.ac.uk/ena/data/view/AY234180
EMBL	BC016281	http://www.ebi.ac.uk/ena/data/view/BC016281
EMBL	BT007103	http://www.ebi.ac.uk/ena/data/view/BT007103
EMBL	CH471136	http://www.ebi.ac.uk/ena/data/view/CH471136
EMBL	CR541937	http://www.ebi.ac.uk/ena/data/view/CR541937
EMBL	CR541962	http://www.ebi.ac.uk/ena/data/view/CR541962
EMBL	U27467	http://www.ebi.ac.uk/ena/data/view/U27467
EMBL	U29680	http://www.ebi.ac.uk/ena/data/view/U29680
EMBL	Y09397	http://www.ebi.ac.uk/ena/data/view/Y09397
Ensembl	ENST00000267953	http://www.ensembl.org/id/ENST00000267953
Ensembl	ENST00000335661	http://www.ensembl.org/id/ENST00000335661
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005741	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005741
GO_function	GO:0015267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015267
GO_function	GO:0042803	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_function	GO:0046982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046982
GO_process	GO:0001836	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001836
GO_process	GO:0007568	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007568
GO_process	GO:0008053	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008053
GO_process	GO:0008630	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008630
GO_process	GO:0021987	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021987
GO_process	GO:0043065	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043065
GO_process	GO:0043066	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043066
GO_process	GO:0097192	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097192
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007005
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007568	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007568
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
GeneCards	BCL2A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=BCL2A1
GeneID	597	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=597
GeneTree	ENSGT00510000048456	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00510000048456
HGNC	HGNC:991	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:991
HOGENOM	HOG000059278	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000059278&db=HOGENOM6
HOVERGEN	HBG004840	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004840&db=HOVERGEN
InParanoid	Q16548	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q16548
IntAct	Q16548	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q16548*
InterPro	IPR002475	http://www.ebi.ac.uk/interpro/entry/IPR002475
InterPro	IPR013282	http://www.ebi.ac.uk/interpro/entry/IPR013282
InterPro	IPR020717	http://www.ebi.ac.uk/interpro/entry/IPR020717
InterPro	IPR020726	http://www.ebi.ac.uk/interpro/entry/IPR020726
InterPro	IPR026298	http://www.ebi.ac.uk/interpro/entry/IPR026298
Jabion	597	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=597
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Gene	hsa:597	http://www.genome.jp/dbget-bin/www_bget?hsa:597
KEGG_Orthology	KO:K02162	http://www.genome.jp/dbget-bin/www_bget?KO:K02162
KEGG_Pathway	ko04064	http://www.genome.jp/kegg-bin/show_pathway?ko04064
KEGG_Pathway	ko05202	http://www.genome.jp/kegg-bin/show_pathway?ko05202
MIM	601056	http://www.ncbi.nlm.nih.gov/omim/601056
MINT	MINT-89617	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-89617
OMA	ENTAEWI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ENTAEWI
OrthoDB	EOG091G0N5N	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0N5N
PANTHER	PTHR11256	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11256
PANTHER	PTHR11256:SF10	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11256:SF10
PDB	2VM6	http://www.ebi.ac.uk/pdbe-srv/view/entry/2VM6
PDB	3I1H	http://www.ebi.ac.uk/pdbe-srv/view/entry/3I1H
PDB	3MQP	http://www.ebi.ac.uk/pdbe-srv/view/entry/3MQP
PDB	4ZEQ	http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZEQ
PDBsum	2VM6	http://www.ebi.ac.uk/pdbsum/2VM6
PDBsum	3I1H	http://www.ebi.ac.uk/pdbsum/3I1H
PDBsum	3MQP	http://www.ebi.ac.uk/pdbsum/3MQP
PDBsum	4ZEQ	http://www.ebi.ac.uk/pdbsum/4ZEQ
PRINTS	PR01862	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01862
PRINTS	PR01867	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01867
PROSITE	PS01080	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01080
PROSITE	PS01258	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01258
PROSITE	PS50062	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50062
PSORT	swissprot:B2LA1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:B2LA1_HUMAN
PSORT-B	swissprot:B2LA1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:B2LA1_HUMAN
PSORT2	swissprot:B2LA1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:B2LA1_HUMAN
Pfam	PF00452	http://pfam.xfam.org/family/PF00452
PharmGKB	PA25303	http://www.pharmgkb.org/do/serve?objId=PA25303&objCls=Gene
Phobius	swissprot:B2LA1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:B2LA1_HUMAN
PhylomeDB	Q16548	http://phylomedb.org/?seqid=Q16548
ProteinModelPortal	Q16548	http://www.proteinmodelportal.org/query/uniprot/Q16548
PubMed	10772918	http://www.ncbi.nlm.nih.gov/pubmed/10772918
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16572171	http://www.ncbi.nlm.nih.gov/pubmed/16572171
PubMed	18812174	http://www.ncbi.nlm.nih.gov/pubmed/18812174
PubMed	23055042	http://www.ncbi.nlm.nih.gov/pubmed/23055042
PubMed	7478596	http://www.ncbi.nlm.nih.gov/pubmed/7478596
PubMed	8605321	http://www.ncbi.nlm.nih.gov/pubmed/8605321
PubMed	9050999	http://www.ncbi.nlm.nih.gov/pubmed/9050999
RefSeq	NP_001108207	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001108207
RefSeq	NP_004040	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_004040
SMR	Q16548	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q16548
STRING	9606.ENSP00000267953	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000267953&targetmode=cogs
UCSC	uc002bfc	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002bfc&org=rat
UniGene	Hs.227817	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.227817
UniProtKB	B2LA1_HUMAN	http://www.uniprot.org/uniprot/B2LA1_HUMAN
UniProtKB-AC	Q16548	http://www.uniprot.org/uniprot/Q16548
charge	swissprot:B2LA1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:B2LA1_HUMAN
eggNOG	ENOG41123S0	http://eggnogapi.embl.de/nog_data/html/tree/ENOG41123S0
eggNOG	KOG4728	http://eggnogapi.embl.de/nog_data/html/tree/KOG4728
epestfind	swissprot:B2LA1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:B2LA1_HUMAN
garnier	swissprot:B2LA1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:B2LA1_HUMAN
helixturnhelix	swissprot:B2LA1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:B2LA1_HUMAN
hmoment	swissprot:B2LA1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:B2LA1_HUMAN
iep	swissprot:B2LA1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:B2LA1_HUMAN
inforesidue	swissprot:B2LA1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:B2LA1_HUMAN
neXtProt	NX_Q16548	http://www.nextprot.org/db/entry/NX_Q16548
octanol	swissprot:B2LA1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:B2LA1_HUMAN
pepcoil	swissprot:B2LA1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:B2LA1_HUMAN
pepdigest	swissprot:B2LA1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:B2LA1_HUMAN
pepinfo	swissprot:B2LA1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:B2LA1_HUMAN
pepnet	swissprot:B2LA1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:B2LA1_HUMAN
pepstats	swissprot:B2LA1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:B2LA1_HUMAN
pepwheel	swissprot:B2LA1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:B2LA1_HUMAN
pepwindow	swissprot:B2LA1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:B2LA1_HUMAN
sigcleave	swissprot:B2LA1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:B2LA1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	KCIP4_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=KChIP4.1; IsoId=Q6PIL6-1; Sequence=Displayed; Name=2; Synonyms=KChIP4.2; IsoId=Q6PIL6-2; Sequence=VSP_015068; Name=3; Synonyms=KChIP4bs, KCHIP4.2; IsoId=Q6PIL6-3; Sequence=VSP_015066; Name=4; Synonyms=KChIP4a, KChIP4.4; IsoId=Q6PIL6-4; Sequence=VSP_015067; Name=5; IsoId=Q6PIL6-5; Sequence=VSP_043321; 
# AltName	Calsenilin-like protein {ECO:0000303|PubMed	11847232}
# AltName	KCIP4_HUMAN	A-type potassium channel modulatory protein 4
# AltName	KCIP4_HUMAN	Potassium channel-interacting protein 4
# BioGrid	123244	15
# CCDS	CCDS3428	-. [Q6PIL6-4]
# CCDS	CCDS43215	-. [Q6PIL6-2]
# CCDS	CCDS43216	-. [Q6PIL6-1]
# CCDS	CCDS43217	-. [Q6PIL6-5]
# CCDS	CCDS47035	-. [Q6PIL6-3]
# CDD	cd00051	EFh; 2
# ChiTaRS	KCNIP4	human
# DOMAIN	KCIP4_HUMAN	The KIS (K-channel inactivation suppressor) domain is required for converting A-type Kv4 current to a slowly inactivating delayed rectifier potassium current. {ECO 0000250}. 
# Ensembl	ENST00000359001	ENSP00000351892; ENSG00000185774. [Q6PIL6-3]
# Ensembl	ENST00000382148	ENSP00000371583; ENSG00000185774. [Q6PIL6-5]
# Ensembl	ENST00000382150	ENSP00000371585; ENSG00000185774. [Q6PIL6-4]
# Ensembl	ENST00000382152	ENSP00000371587; ENSG00000185774. [Q6PIL6-1]
# Ensembl	ENST00000447367	ENSP00000399080; ENSG00000185774. [Q6PIL6-2]
# Ensembl	ENST00000509207	ENSP00000423257; ENSG00000185774. [Q6PIL6-3]
# ExpressionAtlas	Q6PIL6	baseline and differential
# FUNCTION	KCIP4_HUMAN	Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed 11847232, PubMed 18957440, PubMed 23576435). Modulates KCND3/Kv4.3 currents (PubMed 23576435). Isoform 4 does not increase KCND2 expression at the cell membrane (PubMed 18957440). Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane. {ECO 0000250|UniProtKB Q6PHZ8, ECO 0000269|PubMed 11847232, ECO 0000269|PubMed 18957440, ECO 0000269|PubMed 23576435}. 
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005783	endoplasmic reticulum; IEA:UniProtKB-SubCell.
# GO_component	GO:0005829	cytosol; ISS:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0008076	voltage-gated potassium channel complex; ISS:UniProtKB.
# GO_function	GO:0005244	voltage-gated ion channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0005267	potassium channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0005509	calcium ion binding; IDA:UniProtKB.
# GO_function	GO:0015459	potassium channel regulator activity; ISS:UniProtKB.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:0072659	protein localization to plasma membrane; ISS:UniProtKB.
# GO_process	GO:1901379	regulation of potassium ion transmembrane transport; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0007009	plasma membrane organization
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.10.238.10	-; 3.
# Genevisible	Q6PIL6	HS
# HGNC	HGNC:30083	KCNIP4
# InterPro	IPR002048	EF_hand_dom
# InterPro	IPR011992	EF-hand-dom_pair
# InterPro	IPR018247	EF_Hand_1_Ca_BS
# InterPro	IPR028846	Recoverin
# MIM	608182	gene
# Organism	KCIP4_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR23055	PTHR23055
# PROSITE	PS00018	EF_HAND_1; 3
# PROSITE	PS50222	EF_HAND_2; 3
# Pfam	PF13499	EF-hand_7
# Pfam	PF13833	EF-hand_8
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-5576894	Phase 1 - inactivation of fast Na+ channels
# RecName	KCIP4_HUMAN	Kv channel-interacting protein 4
# RefSeq	NP_001030175	NM_001035003.1. [Q6PIL6-5]
# RefSeq	NP_001030176	NM_001035004.1. [Q6PIL6-3]
# RefSeq	NP_079497	NM_025221.5. [Q6PIL6-1]
# RefSeq	NP_671710	NM_147181.3. [Q6PIL6-2]
# RefSeq	NP_671711	NM_147182.3. [Q6PIL6-3]
# RefSeq	NP_671712	NM_147183.3. [Q6PIL6-4]
# RefSeq	XP_016864142	XM_017008653.1. [Q6PIL6-3]
# SIMILARITY	Belongs to the recoverin family. {ECO	0000305}. 
# SIMILARITY	Contains 4 EF-hand domains. {ECO:0000255|PROSITE- ProRule	PRU00448}.
# SMART	SM00054	EFh; 3
# SUBCELLULAR LOCATION	KCIP4_HUMAN	Cell membrane {ECO 0000269|PubMed 11847232}; Peripheral membrane protein {ECO 0000305|PubMed 11847232}. Cytoplasm {ECO 0000269|PubMed 11847232, ECO 0000269|PubMed 23576435}. 
# SUBCELLULAR LOCATION	KCIP4_HUMAN	Isoform 4  Endoplasmic reticulum {ECO 0000269|PubMed 23576435}. 
# SUBUNIT	KCIP4_HUMAN	Component of heteromultimeric potassium channels (PubMed 23576435). Identified in potassium channel complexes containing KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10 (By similarity). Interacts with KCND2 (PubMed 11847232, PubMed 18957440). Interacts with KCND3 (By similarity). Interacts with the C-terminus of PSEN2 and probably PSEN1 (PubMed 11847232). {ECO 0000250|UniProtKB Q6PHZ8, ECO 0000269|PubMed 11847232, ECO 0000269|PubMed 18957440, ECO 0000269|PubMed 23576435, ECO 0000269|PubMed 24811166}. 
# SUPFAM	SSF47473	SSF47473
# TCDB	5.B.1.2	the phagocyte (gp91(phox)) nadph oxidase family
# TISSUE SPECIFICITY	Predominantly expressed in brain. {ECO:0000269|PubMed	11847232}. 
# UCSC	uc003gqf	human. [Q6PIL6-1]
# eggNOG	COG5126	LUCA
# eggNOG	KOG0044	Eukaryota
BLAST	swissprot:KCIP4_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:KCIP4_HUMAN
BioCyc	ZFISH:G66-32335-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32335-MONOMER
COXPRESdb	80333	http://coxpresdb.jp/data/gene/80333.shtml
CleanEx	HS_KCNIP4	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KCNIP4
DOI	10.1016/j.ygeno.2005.07.001	http://dx.doi.org/10.1016/j.ygeno.2005.07.001
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.022509299	http://dx.doi.org/10.1073/pnas.022509299
DOI	10.1074/jbc.M113.466052	http://dx.doi.org/10.1074/jbc.M113.466052
DOI	10.1074/jbc.M114.563452	http://dx.doi.org/10.1074/jbc.M114.563452
DOI	10.1074/jbc.M200897200	http://dx.doi.org/10.1074/jbc.M200897200
DOI	10.1074/jbc.M806852200	http://dx.doi.org/10.1074/jbc.M806852200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AC096576	http://www.ebi.ac.uk/ena/data/view/AC096576
EMBL	AC097505	http://www.ebi.ac.uk/ena/data/view/AC097505
EMBL	AC098597	http://www.ebi.ac.uk/ena/data/view/AC098597
EMBL	AC104065	http://www.ebi.ac.uk/ena/data/view/AC104065
EMBL	AC107462	http://www.ebi.ac.uk/ena/data/view/AC107462
EMBL	AC108147	http://www.ebi.ac.uk/ena/data/view/AC108147
EMBL	AC109360	http://www.ebi.ac.uk/ena/data/view/AC109360
EMBL	AC109636	http://www.ebi.ac.uk/ena/data/view/AC109636
EMBL	AC110296	http://www.ebi.ac.uk/ena/data/view/AC110296
EMBL	AC110612	http://www.ebi.ac.uk/ena/data/view/AC110612
EMBL	AC113606	http://www.ebi.ac.uk/ena/data/view/AC113606
EMBL	AC116641	http://www.ebi.ac.uk/ena/data/view/AC116641
EMBL	AF302044	http://www.ebi.ac.uk/ena/data/view/AF302044
EMBL	AF305072	http://www.ebi.ac.uk/ena/data/view/AF305072
EMBL	AF367023	http://www.ebi.ac.uk/ena/data/view/AF367023
EMBL	AF367024	http://www.ebi.ac.uk/ena/data/view/AF367024
EMBL	AF453246	http://www.ebi.ac.uk/ena/data/view/AF453246
EMBL	AK289922	http://www.ebi.ac.uk/ena/data/view/AK289922
EMBL	AY029176	http://www.ebi.ac.uk/ena/data/view/AY029176
EMBL	AY118170	http://www.ebi.ac.uk/ena/data/view/AY118170
EMBL	BC032520	http://www.ebi.ac.uk/ena/data/view/BC032520
EMBL	CH471069	http://www.ebi.ac.uk/ena/data/view/CH471069
EMBL	DQ148487	http://www.ebi.ac.uk/ena/data/view/DQ148487
EMBL	DQ148488	http://www.ebi.ac.uk/ena/data/view/DQ148488
EMBL	DQ148489	http://www.ebi.ac.uk/ena/data/view/DQ148489
EMBL	DQ148490	http://www.ebi.ac.uk/ena/data/view/DQ148490
EMBL	DQ148491	http://www.ebi.ac.uk/ena/data/view/DQ148491
Ensembl	ENST00000359001	http://www.ensembl.org/id/ENST00000359001
Ensembl	ENST00000382148	http://www.ensembl.org/id/ENST00000382148
Ensembl	ENST00000382150	http://www.ensembl.org/id/ENST00000382150
Ensembl	ENST00000382152	http://www.ensembl.org/id/ENST00000382152
Ensembl	ENST00000447367	http://www.ensembl.org/id/ENST00000447367
Ensembl	ENST00000509207	http://www.ensembl.org/id/ENST00000509207
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0008076	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008076
GO_function	GO:0005244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005244
GO_function	GO:0005267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_function	GO:0015459	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015459
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:0072659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072659
GO_process	GO:1901379	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901379
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0007009	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007009
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.10.238.10	http://www.cathdb.info/version/latest/superfamily/1.10.238.10
GeneCards	KCNIP4	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KCNIP4
GeneID	80333	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80333
GeneTree	ENSGT00760000118820	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118820
H-InvDB	HIX0120159	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0120159
HGNC	HGNC:30083	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:30083
HOGENOM	HOG000233019	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233019&db=HOGENOM6
HOVERGEN	HBG108179	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108179&db=HOVERGEN
HPA	HPA022862	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA022862
InParanoid	Q6PIL6	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6PIL6
IntAct	Q6PIL6	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q6PIL6*
InterPro	IPR002048	http://www.ebi.ac.uk/interpro/entry/IPR002048
InterPro	IPR011992	http://www.ebi.ac.uk/interpro/entry/IPR011992
InterPro	IPR018247	http://www.ebi.ac.uk/interpro/entry/IPR018247
InterPro	IPR028846	http://www.ebi.ac.uk/interpro/entry/IPR028846
Jabion	80333	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=80333
KEGG_Gene	hsa:80333	http://www.genome.jp/dbget-bin/www_bget?hsa:80333
MIM	608182	http://www.ncbi.nlm.nih.gov/omim/608182
OMA	DTVEDEM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DTVEDEM
OrthoDB	EOG091G11T4	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G11T4
PANTHER	PTHR23055	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23055
PROSITE	PS00018	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00018
PROSITE	PS50222	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50222
PSORT	swissprot:KCIP4_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:KCIP4_HUMAN
PSORT-B	swissprot:KCIP4_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:KCIP4_HUMAN
PSORT2	swissprot:KCIP4_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:KCIP4_HUMAN
Pfam	PF13499	http://pfam.xfam.org/family/PF13499
Pfam	PF13833	http://pfam.xfam.org/family/PF13833
PharmGKB	PA134893552	http://www.pharmgkb.org/do/serve?objId=PA134893552&objCls=Gene
Phobius	swissprot:KCIP4_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:KCIP4_HUMAN
PhylomeDB	Q6PIL6	http://phylomedb.org/?seqid=Q6PIL6
ProteinModelPortal	Q6PIL6	http://www.proteinmodelportal.org/query/uniprot/Q6PIL6
PubMed	11805342	http://www.ncbi.nlm.nih.gov/pubmed/11805342
PubMed	11847232	http://www.ncbi.nlm.nih.gov/pubmed/11847232
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	16112838	http://www.ncbi.nlm.nih.gov/pubmed/16112838
PubMed	18957440	http://www.ncbi.nlm.nih.gov/pubmed/18957440
PubMed	23576435	http://www.ncbi.nlm.nih.gov/pubmed/23576435
PubMed	24811166	http://www.ncbi.nlm.nih.gov/pubmed/24811166
Reactome	R-HSA-5576894	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576894
RefSeq	NP_001030175	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001030175
RefSeq	NP_001030176	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001030176
RefSeq	NP_079497	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_079497
RefSeq	NP_671710	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_671710
RefSeq	NP_671711	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_671711
RefSeq	NP_671712	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_671712
RefSeq	XP_016864142	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016864142
SMART	SM00054	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00054
SMR	Q6PIL6	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q6PIL6
STRING	9606.ENSP00000371587	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000371587&targetmode=cogs
SUPFAM	SSF47473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47473
TCDB	5.B.1.2	http://www.tcdb.org/search/result.php?tc=5.B.1.2
UCSC	uc003gqf	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003gqf&org=rat
UniGene	Hs.655705	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.655705
UniProtKB	KCIP4_HUMAN	http://www.uniprot.org/uniprot/KCIP4_HUMAN
UniProtKB-AC	Q6PIL6	http://www.uniprot.org/uniprot/Q6PIL6
charge	swissprot:KCIP4_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:KCIP4_HUMAN
eggNOG	COG5126	http://eggnogapi.embl.de/nog_data/html/tree/COG5126
eggNOG	KOG0044	http://eggnogapi.embl.de/nog_data/html/tree/KOG0044
epestfind	swissprot:KCIP4_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:KCIP4_HUMAN
garnier	swissprot:KCIP4_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:KCIP4_HUMAN
helixturnhelix	swissprot:KCIP4_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCIP4_HUMAN
hmoment	swissprot:KCIP4_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:KCIP4_HUMAN
iep	swissprot:KCIP4_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:KCIP4_HUMAN
inforesidue	swissprot:KCIP4_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:KCIP4_HUMAN
neXtProt	NX_Q6PIL6	http://www.nextprot.org/db/entry/NX_Q6PIL6
octanol	swissprot:KCIP4_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:KCIP4_HUMAN
pepcoil	swissprot:KCIP4_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:KCIP4_HUMAN
pepdigest	swissprot:KCIP4_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:KCIP4_HUMAN
pepinfo	swissprot:KCIP4_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:KCIP4_HUMAN
pepnet	swissprot:KCIP4_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:KCIP4_HUMAN
pepstats	swissprot:KCIP4_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:KCIP4_HUMAN
pepwheel	swissprot:KCIP4_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:KCIP4_HUMAN
pepwindow	swissprot:KCIP4_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:KCIP4_HUMAN
sigcleave	swissprot:KCIP4_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:KCIP4_HUMAN
## Database	ID	URL or Descriptions
# AltName	XPO5_HUMAN	Ran-binding protein 21
# BioGrid	121574	71
# ChiTaRS	XPO5	human
# Ensembl	ENST00000265351	ENSP00000265351; ENSG00000124571
# ExpressionAtlas	Q9HAV4	baseline and differential
# FUNCTION	XPO5_HUMAN	Mediates the nuclear export of micro-RNA precursors, which form short hairpins. Also mediates the nuclear export of synthetic short hairpin RNAs used for RNA interference, and adenovirus VA1 dsRNA. In some circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes dsRNAs that lack a 5'-overhang in a sequence- independent manner, have only a short 3'-overhang, and that have a double-stranded length of at least 15 base-pairs. Binding is dependent on Ran-GTP. 
# FUNCTION	XPO5_HUMAN	Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a RanGTP-dependent manner. 
# GO_component	GO:0005634	nucleus; IDA:BHF-UCL.
# GO_component	GO:0005654	nucleoplasm; IDA:HPA.
# GO_component	GO:0005737	cytoplasm; IDA:BHF-UCL.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0042565	RNA nuclear export complex; IDA:BHF-UCL.
# GO_function	GO:0000049	tRNA binding; IEA:UniProtKB-KW.
# GO_function	GO:0003723	RNA binding; TAS:Reactome.
# GO_function	GO:0003729	mRNA binding; IDA:BHF-UCL.
# GO_function	GO:0005049	nuclear export signal receptor activity; IBA:GO_Central.
# GO_function	GO:0008536	Ran GTPase binding; IDA:BHF-UCL.
# GO_function	GO:0044822	poly(A) RNA binding; IDA:UniProtKB.
# GO_function	GO:0070883	pre-miRNA binding; IDA:BHF-UCL.
# GO_function	GO:0090631	pre-miRNA transporter activity; IMP:BHF-UCL.
# GO_process	GO:0006611	protein export from nucleus; IDA:UniProtKB.
# GO_process	GO:0031047	gene silencing by RNA; TAS:Reactome.
# GO_process	GO:0035281	pre-miRNA export from nucleus; IDA:BHF-UCL.
# GO_process	GO:0046825	regulation of protein export from nucleus; IBA:GO_Central.
# GO_process	GO:1900370	positive regulation of RNA interference; IDA:BHF-UCL.
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0003723	RNA binding
# GOslim_function	GO:0003729	mRNA binding
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.25.10.10	-; 2.
# Genevisible	Q9HAV4	HS
# HGNC	HGNC:17675	XPO5
# IntAct	Q9HAV4	23
# InterPro	IPR001494	Importin-beta_N
# InterPro	IPR011989	ARM-like
# InterPro	IPR013598	Exportin-1/Importin-b-like
# InterPro	IPR016024	ARM-type_fold
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko03016	 Transfer RNA biogenesis
# KEGG_Pathway	ko03013	RNA transport
# MIM	607845	gene
# Organism	XPO5_HUMAN	Homo sapiens (Human)
# PDB	3A6P	X-ray; 2.92 A; A/F=1-1204
# PIR	T46411	T46411
# Pfam	PF08389	Xpo1
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-203927	MicroRNA (miRNA) biogenesis
# RecName	XPO5_HUMAN	Exportin-5
# RefSeq	NP_065801	NM_020750.2
# SEQUENCE CAUTION	XPO5_HUMAN	Sequence=AAH00129.1; Type=Erroneous initiation; Evidence={ECO 0000305}; Sequence=BAA86605.2; Type=Erroneous initiation; Evidence={ECO 0000305}; Sequence=BAA91547.1; Type=Frameshift; Positions=920; Evidence={ECO 0000305}; Sequence=CAI42640.1; Type=Erroneous gene model prediction; Evidence={ECO 0000305};
# SIMILARITY	Belongs to the exportin family. {ECO	0000305}. 
# SMART	SM00913	IBN_N
# SUBCELLULAR LOCATION	XPO5_HUMAN	Nucleus {ECO 0000269|PubMed 11777942}. Cytoplasm {ECO 0000269|PubMed 11777942}. Note=Shuttles between the nucleus and the cytoplasm. 
# SUBUNIT	XPO5_HUMAN	Component of a nuclear export receptor complex composed of XPO5, Ran, dsRNA-binding proteins and dsRNA. Found in a nuclear export complex with XPO5, Ran, EEF1A1, and aminoacylated tRNA. Found in a nuclear export complex with XPO5, Ran, ILF3 and dsRNA. Found in a nuclear export complex with XPO5, Ran and pre-miRNA. Found in a nuclear export complex with XPO5, Ran, ILF3 and minihelix VA1 dsRNA. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and dsRNA. Interacts with EEF1A1, ILF3, NUP153, NUP214 and ZNF346. Interacts with Ran and cargo proteins in a GTP- dependent manner. Interacts with isoform 5 of ADAR/ADAR1 (via DRBM domains). Interacts with SMAD4; mediates nuclear export of SMAD4 (PubMed 26878725). {ECO 0000269|PubMed 11777942, ECO 0000269|PubMed 12426392, ECO 0000269|PubMed 12426393, ECO 0000269|PubMed 14570900, ECO 0000269|PubMed 14631048, ECO 0000269|PubMed 14730017, ECO 0000269|PubMed 15254228, ECO 0000269|PubMed 19124606, ECO 0000269|PubMed 26878725}. 
# SUPFAM	SSF48371	SSF48371; 4
# TCDB	1.I.1.1	the nuclear pore complex (npc) family
# TISSUE SPECIFICITY	Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed	11777942}. 
# UCSC	uc003ovp	human
# eggNOG	COG5101	LUCA
# eggNOG	KOG2020	Eukaryota
BLAST	swissprot:XPO5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:XPO5_HUMAN
BioCyc	ZFISH:ENSG00000124571-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000124571-MONOMER
COXPRESdb	57510	http://coxpresdb.jp/data/gene/57510.shtml
DIP	DIP-34547N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-34547N
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng.3512	http://dx.doi.org/10.1038/ng.3512
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.C200668200	http://dx.doi.org/10.1074/jbc.C200668200
DOI	10.1074/jbc.M306808200	http://dx.doi.org/10.1074/jbc.M306808200
DOI	10.1074/mcp.M111.015131	http://dx.doi.org/10.1074/mcp.M111.015131
DOI	10.1083/jcb.200110082	http://dx.doi.org/10.1083/jcb.200110082
DOI	10.1093/dnares/6.5.337	http://dx.doi.org/10.1093/dnares/6.5.337
DOI	10.1093/dnares/9.3.99	http://dx.doi.org/10.1093/dnares/9.3.99
DOI	10.1093/emboj/cdf613	http://dx.doi.org/10.1093/emboj/cdf613
DOI	10.1093/emboj/cdf620	http://dx.doi.org/10.1093/emboj/cdf620
DOI	10.1101/gad.1158803	http://dx.doi.org/10.1101/gad.1158803
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1090599	http://dx.doi.org/10.1126/science.1090599
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1128/MCB.01519-08	http://dx.doi.org/10.1128/MCB.01519-08
DOI	10.1128/MCB.24.15.6608-6619.2004	http://dx.doi.org/10.1128/MCB.24.15.6608-6619.2004
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1261/rna.5167604	http://dx.doi.org/10.1261/rna.5167604
DOI	10.1261/rna.7233305	http://dx.doi.org/10.1261/rna.7233305
EMBL	AB033117	http://www.ebi.ac.uk/ena/data/view/AB033117
EMBL	AF271159	http://www.ebi.ac.uk/ena/data/view/AF271159
EMBL	AF298880	http://www.ebi.ac.uk/ena/data/view/AF298880
EMBL	AK001195	http://www.ebi.ac.uk/ena/data/view/AK001195
EMBL	AK022718	http://www.ebi.ac.uk/ena/data/view/AK022718
EMBL	AL137467	http://www.ebi.ac.uk/ena/data/view/AL137467
EMBL	AL355802	http://www.ebi.ac.uk/ena/data/view/AL355802
EMBL	BC000129	http://www.ebi.ac.uk/ena/data/view/BC000129
EMBL	BC008347	http://www.ebi.ac.uk/ena/data/view/BC008347
EMBL	BC009969	http://www.ebi.ac.uk/ena/data/view/BC009969
EMBL	BC062635	http://www.ebi.ac.uk/ena/data/view/BC062635
Ensembl	ENST00000265351	http://www.ensembl.org/id/ENST00000265351
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0042565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042565
GO_function	GO:0000049	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049
GO_function	GO:0003723	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723
GO_function	GO:0003729	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003729
GO_function	GO:0005049	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005049
GO_function	GO:0008536	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008536
GO_function	GO:0044822	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044822
GO_function	GO:0070883	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070883
GO_function	GO:0090631	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090631
GO_process	GO:0006611	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006611
GO_process	GO:0031047	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031047
GO_process	GO:0035281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035281
GO_process	GO:0046825	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046825
GO_process	GO:1900370	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900370
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0003723	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723
GOslim_function	GO:0003729	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003729
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
GeneCards	XPO5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=XPO5
GeneID	57510	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57510
GeneTree	ENSGT00390000013979	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000013979
H-InvDB	HIX0005908	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0005908
HGNC	HGNC:17675	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17675
HOVERGEN	HBG056281	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG056281&db=HOVERGEN
HPA	CAB012357	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB012357
HPA	HPA018402	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA018402
HPA	HPA023959	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA023959
HPA	HPA029909	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA029909
HPA	HPA029910	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA029910
InParanoid	Q9HAV4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9HAV4
IntAct	Q9HAV4	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9HAV4*
InterPro	IPR001494	http://www.ebi.ac.uk/interpro/entry/IPR001494
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR013598	http://www.ebi.ac.uk/interpro/entry/IPR013598
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
Jabion	57510	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=57510
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko03016	http://www.genome.jp/dbget-bin/www_bget?ko03016
KEGG_Gene	hsa:57510	http://www.genome.jp/dbget-bin/www_bget?hsa:57510
KEGG_Orthology	KO:K14289	http://www.genome.jp/dbget-bin/www_bget?KO:K14289
KEGG_Pathway	ko03013	http://www.genome.jp/kegg-bin/show_pathway?ko03013
MIM	607845	http://www.ncbi.nlm.nih.gov/omim/607845
MINT	MINT-264827	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-264827
OMA	VLKPPNE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VLKPPNE
OrthoDB	EOG091G0154	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0154
PDB	3A6P	http://www.ebi.ac.uk/pdbe-srv/view/entry/3A6P
PDBsum	3A6P	http://www.ebi.ac.uk/pdbsum/3A6P
PSORT	swissprot:XPO5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:XPO5_HUMAN
PSORT-B	swissprot:XPO5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:XPO5_HUMAN
PSORT2	swissprot:XPO5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:XPO5_HUMAN
Pfam	PF08389	http://pfam.xfam.org/family/PF08389
PharmGKB	PA134979214	http://www.pharmgkb.org/do/serve?objId=PA134979214&objCls=Gene
Phobius	swissprot:XPO5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:XPO5_HUMAN
PhylomeDB	Q9HAV4	http://phylomedb.org/?seqid=Q9HAV4
ProteinModelPortal	Q9HAV4	http://www.proteinmodelportal.org/query/uniprot/Q9HAV4
PubMed	10574462	http://www.ncbi.nlm.nih.gov/pubmed/10574462
PubMed	11777942	http://www.ncbi.nlm.nih.gov/pubmed/11777942
PubMed	12168954	http://www.ncbi.nlm.nih.gov/pubmed/12168954
PubMed	12426392	http://www.ncbi.nlm.nih.gov/pubmed/12426392
PubMed	12426393	http://www.ncbi.nlm.nih.gov/pubmed/12426393
PubMed	12509441	http://www.ncbi.nlm.nih.gov/pubmed/12509441
PubMed	14570900	http://www.ncbi.nlm.nih.gov/pubmed/14570900
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14631048	http://www.ncbi.nlm.nih.gov/pubmed/14631048
PubMed	14681208	http://www.ncbi.nlm.nih.gov/pubmed/14681208
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	14730017	http://www.ncbi.nlm.nih.gov/pubmed/14730017
PubMed	15254228	http://www.ncbi.nlm.nih.gov/pubmed/15254228
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15613540	http://www.ncbi.nlm.nih.gov/pubmed/15613540
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	19124606	http://www.ncbi.nlm.nih.gov/pubmed/19124606
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	22223895	http://www.ncbi.nlm.nih.gov/pubmed/22223895
PubMed	26878725	http://www.ncbi.nlm.nih.gov/pubmed/26878725
Reactome	R-HSA-203927	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-203927
RefSeq	NP_065801	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_065801
SMART	SM00913	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00913
SMR	Q9HAV4	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9HAV4
STRING	9606.ENSP00000265351	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000265351&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
TCDB	1.I.1.1	http://www.tcdb.org/search/result.php?tc=1.I.1.1
UCSC	uc003ovp	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ovp&org=rat
UniGene	Hs.203206	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.203206
UniProtKB	XPO5_HUMAN	http://www.uniprot.org/uniprot/XPO5_HUMAN
UniProtKB-AC	Q9HAV4	http://www.uniprot.org/uniprot/Q9HAV4
charge	swissprot:XPO5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:XPO5_HUMAN
eggNOG	COG5101	http://eggnogapi.embl.de/nog_data/html/tree/COG5101
eggNOG	KOG2020	http://eggnogapi.embl.de/nog_data/html/tree/KOG2020
epestfind	swissprot:XPO5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:XPO5_HUMAN
garnier	swissprot:XPO5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:XPO5_HUMAN
helixturnhelix	swissprot:XPO5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:XPO5_HUMAN
hmoment	swissprot:XPO5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:XPO5_HUMAN
iep	swissprot:XPO5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:XPO5_HUMAN
inforesidue	swissprot:XPO5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:XPO5_HUMAN
neXtProt	NX_Q9HAV4	http://www.nextprot.org/db/entry/NX_Q9HAV4
octanol	swissprot:XPO5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:XPO5_HUMAN
pepcoil	swissprot:XPO5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:XPO5_HUMAN
pepdigest	swissprot:XPO5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:XPO5_HUMAN
pepinfo	swissprot:XPO5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:XPO5_HUMAN
pepnet	swissprot:XPO5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:XPO5_HUMAN
pepstats	swissprot:XPO5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:XPO5_HUMAN
pepwheel	swissprot:XPO5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:XPO5_HUMAN
pepwindow	swissprot:XPO5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:XPO5_HUMAN
sigcleave	swissprot:XPO5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:XPO5_HUMAN
## Database	ID	URL or Descriptions
# AltName	COPT1_HUMAN	Copper transporter 1
# AltName	COPT1_HUMAN	Solute carrier family 31 member 1
# BioGrid	107712	11
# DrugBank	DB00188	Bortezomib
# DrugBank	DB00515	Cisplatin
# DrugBank	DB00526	Oxaliplatin
# DrugBank	DB00958	Carboplatin
# Ensembl	ENST00000374212	ENSP00000363329; ENSG00000136868
# ExpressionAtlas	O15431	baseline and differential
# FUNCTION	COPT1_HUMAN	High-affinity, saturable copper transporter involved in dietary copper uptake. {ECO 0000269|PubMed 11734551}. 
# GO_component	GO:0005770	late endosome; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0043025	neuronal cell body; IEA:Ensembl.
# GO_component	GO:0055037	recycling endosome; IEA:Ensembl.
# GO_function	GO:0005375	copper ion transmembrane transporter activity; TAS:Reactome.
# GO_function	GO:0015088	copper uptake transmembrane transporter activity; IEA:Ensembl.
# GO_process	GO:0006825	copper ion transport; TAS:ProtInc.
# GO_process	GO:0006855	drug transmembrane transport; IEA:Ensembl.
# GO_process	GO:0006878	cellular copper ion homeostasis; IEA:Ensembl.
# GO_process	GO:0072719	cellular response to cisplatin; IEA:Ensembl.
# GO_process	GO:1902861	copper ion import into cell; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	O15431	HS
# HGNC	HGNC:11016	SLC31A1
# InterPro	IPR007274	Cop_transporter
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04978	Mineral absorption
# MIM	603085	gene
# Organism	COPT1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12483	PTHR12483
# PDB	2LS2	NMR; -; A=64-87
# PDB	2LS3	NMR; -; A=132-157
# PDB	2LS4	NMR; -; A=156-179
# PTM	COPT1_HUMAN	O-Glycosylation at Thr-27 protects from proteolytic cleavage in the N-terminal extracellular domain. {ECO 0000269|PubMed 17525160}. 
# Pfam	PF04145	Ctr
# Proteomes	UP000005640	Chromosome 9
# Reactome	R-HSA-425410	Metal ion SLC transporters
# RecName	COPT1_HUMAN	High affinity copper uptake protein 1
# RefSeq	NP_001850	NM_001859.3
# SIMILARITY	Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	COPT1_HUMAN	Cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membrane in intestinal epithelial cells. {ECO 0000250}. 
# SUBUNIT	Homotrimer. {ECO:0000269|PubMed	16501047}. 
# TCDB	1.A.56.1	the copper transporter (ctr) family
# UCSC	uc004bgu	human
# eggNOG	ENOG4111I8D	LUCA
# eggNOG	KOG3386	Eukaryota
BLAST	swissprot:COPT1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:COPT1_HUMAN
BioCyc	ZFISH:ENSG00000136868-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000136868-MONOMER
COXPRESdb	1317	http://coxpresdb.jp/data/gene/1317.shtml
CleanEx	HS_SLC31A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC31A1
DIP	DIP-48727N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48727N
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0509929103	http://dx.doi.org/10.1073/pnas.0509929103
DOI	10.1073/pnas.94.14.7481	http://dx.doi.org/10.1073/pnas.94.14.7481
DOI	10.1074/jbc.M104728200	http://dx.doi.org/10.1074/jbc.M104728200
DOI	10.1074/jbc.M701806200	http://dx.doi.org/10.1074/jbc.M701806200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DrugBank	DB00188	http://www.drugbank.ca/drugs/DB00188
DrugBank	DB00515	http://www.drugbank.ca/drugs/DB00515
DrugBank	DB00526	http://www.drugbank.ca/drugs/DB00526
DrugBank	DB00958	http://www.drugbank.ca/drugs/DB00958
EMBL	AK222866	http://www.ebi.ac.uk/ena/data/view/AK222866
EMBL	AK292511	http://www.ebi.ac.uk/ena/data/view/AK292511
EMBL	AL449305	http://www.ebi.ac.uk/ena/data/view/AL449305
EMBL	AL831843	http://www.ebi.ac.uk/ena/data/view/AL831843
EMBL	BC013611	http://www.ebi.ac.uk/ena/data/view/BC013611
EMBL	CH471090	http://www.ebi.ac.uk/ena/data/view/CH471090
EMBL	U83460	http://www.ebi.ac.uk/ena/data/view/U83460
Ensembl	ENST00000374212	http://www.ensembl.org/id/ENST00000374212
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005770	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005770
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0055037	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055037
GO_function	GO:0005375	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005375
GO_function	GO:0015088	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015088
GO_process	GO:0006825	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006825
GO_process	GO:0006855	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006855
GO_process	GO:0006878	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006878
GO_process	GO:0072719	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072719
GO_process	GO:1902861	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902861
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC31A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC31A1
GeneID	1317	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1317
GeneTree	ENSGT00530000063415	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000063415
HGNC	HGNC:11016	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:11016
HOGENOM	HOG000195393	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000195393&db=HOGENOM6
HOVERGEN	HBG065767	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG065767&db=HOVERGEN
HPA	HPA013810	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA013810
InParanoid	O15431	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O15431
InterPro	IPR007274	http://www.ebi.ac.uk/interpro/entry/IPR007274
Jabion	1317	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1317
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:1317	http://www.genome.jp/dbget-bin/www_bget?hsa:1317
KEGG_Orthology	KO:K14686	http://www.genome.jp/dbget-bin/www_bget?KO:K14686
KEGG_Pathway	ko04978	http://www.genome.jp/kegg-bin/show_pathway?ko04978
MIM	603085	http://www.ncbi.nlm.nih.gov/omim/603085
MINT	MINT-5003806	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5003806
OMA	VGEVVHK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VGEVVHK
OrthoDB	EOG091G0VVR	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0VVR
PANTHER	PTHR12483	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12483
PDB	2LS2	http://www.ebi.ac.uk/pdbe-srv/view/entry/2LS2
PDB	2LS3	http://www.ebi.ac.uk/pdbe-srv/view/entry/2LS3
PDB	2LS4	http://www.ebi.ac.uk/pdbe-srv/view/entry/2LS4
PDBsum	2LS2	http://www.ebi.ac.uk/pdbsum/2LS2
PDBsum	2LS3	http://www.ebi.ac.uk/pdbsum/2LS3
PDBsum	2LS4	http://www.ebi.ac.uk/pdbsum/2LS4
PSORT	swissprot:COPT1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:COPT1_HUMAN
PSORT-B	swissprot:COPT1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:COPT1_HUMAN
PSORT2	swissprot:COPT1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:COPT1_HUMAN
Pfam	PF04145	http://pfam.xfam.org/family/PF04145
PharmGKB	PA118	http://www.pharmgkb.org/do/serve?objId=PA118&objCls=Gene
Phobius	swissprot:COPT1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:COPT1_HUMAN
PhylomeDB	O15431	http://phylomedb.org/?seqid=O15431
ProteinModelPortal	O15431	http://www.proteinmodelportal.org/query/uniprot/O15431
PubMed	11734551	http://www.ncbi.nlm.nih.gov/pubmed/11734551
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16501047	http://www.ncbi.nlm.nih.gov/pubmed/16501047
PubMed	17525160	http://www.ncbi.nlm.nih.gov/pubmed/17525160
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	9207117	http://www.ncbi.nlm.nih.gov/pubmed/9207117
Reactome	R-HSA-425410	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425410
RefSeq	NP_001850	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001850
SMR	O15431	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O15431
STRING	9606.ENSP00000363329	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000363329&targetmode=cogs
TCDB	1.A.56.1	http://www.tcdb.org/search/result.php?tc=1.A.56.1
UCSC	uc004bgu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004bgu&org=rat
UniGene	Hs.532315	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.532315
UniProtKB	COPT1_HUMAN	http://www.uniprot.org/uniprot/COPT1_HUMAN
UniProtKB-AC	O15431	http://www.uniprot.org/uniprot/O15431
charge	swissprot:COPT1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:COPT1_HUMAN
eggNOG	ENOG4111I8D	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111I8D
eggNOG	KOG3386	http://eggnogapi.embl.de/nog_data/html/tree/KOG3386
epestfind	swissprot:COPT1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:COPT1_HUMAN
garnier	swissprot:COPT1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:COPT1_HUMAN
helixturnhelix	swissprot:COPT1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:COPT1_HUMAN
hmoment	swissprot:COPT1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:COPT1_HUMAN
iep	swissprot:COPT1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:COPT1_HUMAN
inforesidue	swissprot:COPT1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:COPT1_HUMAN
neXtProt	NX_O15431	http://www.nextprot.org/db/entry/NX_O15431
octanol	swissprot:COPT1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:COPT1_HUMAN
pepcoil	swissprot:COPT1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:COPT1_HUMAN
pepdigest	swissprot:COPT1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:COPT1_HUMAN
pepinfo	swissprot:COPT1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:COPT1_HUMAN
pepnet	swissprot:COPT1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:COPT1_HUMAN
pepstats	swissprot:COPT1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:COPT1_HUMAN
pepwheel	swissprot:COPT1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:COPT1_HUMAN
pepwindow	swissprot:COPT1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:COPT1_HUMAN
sigcleave	swissprot:COPT1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:COPT1_HUMAN
## Database	ID	URL or Descriptions
# AltName	S38A8_HUMAN	Solute carrier family 38 member 8
# DISEASE	S38A8_HUMAN	Foveal hypoplasia 2 (FVH2) [MIM 609218]  An isolated form of foveal hypoplasia, a developmental defect of the eye defined as the lack of foveal depression with continuity of all neurosensory retinal layers in the presumed foveal area. Clinical features include absence of foveal pit on optical coherence tomography, absence of foveal hyperpigmentation, absence of foveal avascularity, absence of foveal and macular reflexes, decreased visual acuity, and nystagmus. Optic nerve misrouting and anterior segment dysgenesis are observed in some FVH2 patients. {ECO 0000269|PubMed 24045842, ECO 0000269|PubMed 24290379}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000299709	ENSP00000299709; ENSG00000166558
# ExpressionAtlas	A6NNN8	baseline and differential
# FUNCTION	S38A8_HUMAN	Putative sodium-dependent amino acid/proton antiporter. {ECO 0000250}. 
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0015171	amino acid transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0003333	amino acid transmembrane transport; IBA:GO_Central.
# GO_process	GO:0006814	sodium ion transport; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# HGNC	HGNC:32434	SLC38A8
# InterPro	IPR013057	AA_transpt_TM
# KEGG_Brite	ko02001	Solute carrier family
# MIM	609218	phenotype
# MIM	615585	gene
# Organism	S38A8_HUMAN	Homo sapiens (Human)
# Orphanet	397618	Foveal hypoplasia-optic nerve decussation defect-anterior segment dysgenesis syndrome
# Pfam	PF01490	Aa_trans
# Proteomes	UP000005640	Chromosome 16
# RecName	S38A8_HUMAN	Putative sodium-coupled neutral amino acid transporter 8
# RefSeq	NP_001073911	NM_001080442.2
# RefSeq	XP_016878435	XM_017022946.1
# SIMILARITY	Belongs to the amino acid/polyamine transporter 2 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	S38A8_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	2.A.18.6.12	the amino acid/auxin permease (aaap) family
# TISSUE SPECIFICITY	Expressed in fetal and adult brain, and spinal cord. In the brain, it is localized in the cell body and axon of the majority of neuronal cells and in a subset of glial cells. Found throughout the neuronal retina, with higher expression levels in the inner and outer plexiform layers and the photoreceptor layer. Very weak expression is also present in the kidneys, thymus, and testes. {ECO:0000269|PubMed	24290379}. 
# UCSC	uc002fhg	human
# eggNOG	COG0814	LUCA
# eggNOG	KOG1305	Eukaryota
BLAST	swissprot:S38A8_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S38A8_HUMAN
COXPRESdb	146167	http://coxpresdb.jp/data/gene/146167.shtml
CleanEx	HS_SLC38A8	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC38A8
DOI	10.1016/j.ajhg.2013.11.002	http://dx.doi.org/10.1016/j.ajhg.2013.11.002
DOI	10.1038/ejhg.2013.212	http://dx.doi.org/10.1038/ejhg.2013.212
DOI	10.1038/nature03187	http://dx.doi.org/10.1038/nature03187
EMBL	AC040169	http://www.ebi.ac.uk/ena/data/view/AC040169
Ensembl	ENST00000299709	http://www.ensembl.org/id/ENST00000299709
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0015171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171
GO_process	GO:0003333	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003333
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC38A8	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC38A8
GeneID	146167	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=146167
GeneTree	ENSGT00710000106751	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00710000106751
HGNC	HGNC:32434	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:32434
HOGENOM	HOG000008036	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000008036&db=HOGENOM6
HOVERGEN	HBG055999	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG055999&db=HOVERGEN
InParanoid	A6NNN8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=A6NNN8
InterPro	IPR013057	http://www.ebi.ac.uk/interpro/entry/IPR013057
Jabion	146167	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=146167
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:146167	http://www.genome.jp/dbget-bin/www_bget?hsa:146167
KEGG_Orthology	KO:K14994	http://www.genome.jp/dbget-bin/www_bget?KO:K14994
MIM	609218	http://www.ncbi.nlm.nih.gov/omim/609218
MIM	615585	http://www.ncbi.nlm.nih.gov/omim/615585
OMA	PRVKCCL	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PRVKCCL
Orphanet	397618	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=397618
OrthoDB	EOG091G08A4	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08A4
PSORT	swissprot:S38A8_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S38A8_HUMAN
PSORT-B	swissprot:S38A8_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S38A8_HUMAN
PSORT2	swissprot:S38A8_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S38A8_HUMAN
Pfam	PF01490	http://pfam.xfam.org/family/PF01490
PharmGKB	PA162403773	http://www.pharmgkb.org/do/serve?objId=PA162403773&objCls=Gene
Phobius	swissprot:S38A8_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S38A8_HUMAN
PhylomeDB	A6NNN8	http://phylomedb.org/?seqid=A6NNN8
ProteinModelPortal	A6NNN8	http://www.proteinmodelportal.org/query/uniprot/A6NNN8
PubMed	15616553	http://www.ncbi.nlm.nih.gov/pubmed/15616553
PubMed	24045842	http://www.ncbi.nlm.nih.gov/pubmed/24045842
PubMed	24290379	http://www.ncbi.nlm.nih.gov/pubmed/24290379
RefSeq	NP_001073911	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001073911
RefSeq	XP_016878435	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016878435
STRING	9606.ENSP00000299709	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000299709&targetmode=cogs
TCDB	2.A.18.6.12	http://www.tcdb.org/search/result.php?tc=2.A.18.6.12
UCSC	uc002fhg	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002fhg&org=rat
UniProtKB	S38A8_HUMAN	http://www.uniprot.org/uniprot/S38A8_HUMAN
UniProtKB-AC	A6NNN8	http://www.uniprot.org/uniprot/A6NNN8
charge	swissprot:S38A8_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S38A8_HUMAN
eggNOG	COG0814	http://eggnogapi.embl.de/nog_data/html/tree/COG0814
eggNOG	KOG1305	http://eggnogapi.embl.de/nog_data/html/tree/KOG1305
epestfind	swissprot:S38A8_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S38A8_HUMAN
garnier	swissprot:S38A8_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S38A8_HUMAN
helixturnhelix	swissprot:S38A8_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S38A8_HUMAN
hmoment	swissprot:S38A8_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S38A8_HUMAN
iep	swissprot:S38A8_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S38A8_HUMAN
inforesidue	swissprot:S38A8_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S38A8_HUMAN
neXtProt	NX_A6NNN8	http://www.nextprot.org/db/entry/NX_A6NNN8
octanol	swissprot:S38A8_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S38A8_HUMAN
pepcoil	swissprot:S38A8_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S38A8_HUMAN
pepdigest	swissprot:S38A8_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S38A8_HUMAN
pepinfo	swissprot:S38A8_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S38A8_HUMAN
pepnet	swissprot:S38A8_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S38A8_HUMAN
pepstats	swissprot:S38A8_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S38A8_HUMAN
pepwheel	swissprot:S38A8_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S38A8_HUMAN
pepwindow	swissprot:S38A8_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S38A8_HUMAN
sigcleave	swissprot:S38A8_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S38A8_HUMAN
## Database	ID	URL or Descriptions
# AltName	ZNT7_HUMAN	Solute carrier family 30 member 7
# AltName	ZNT7_HUMAN	Znt-like transporter 2
# BioGrid	127176	19
# ChiTaRS	SLC30A7	human
# Ensembl	ENST00000357650	ENSP00000350278; ENSG00000162695
# Ensembl	ENST00000370112	ENSP00000359130; ENSG00000162695
# ExpressionAtlas	Q8NEW0	baseline and differential
# FUNCTION	ZNT7_HUMAN	Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc- requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity). {ECO 0000250, ECO 0000269|PubMed 15276077, ECO 0000269|PubMed 15994300}. 
# GO_component	GO:0005737	cytoplasm; IDA:BHF-UCL.
# GO_component	GO:0005794	Golgi apparatus; IDA:LIFEdb.
# GO_component	GO:0016020	membrane; IBA:GO_Central.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0016023	cytoplasmic, membrane-bounded vesicle; IEA:Ensembl.
# GO_component	GO:0031982	vesicle; IDA:BHF-UCL.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IEA:Ensembl.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005385	zinc ion transmembrane transporter activity; IBA:GO_Central.
# GO_process	GO:0010043	response to zinc ion; IBA:GO_Central.
# GO_process	GO:0032119	sequestering of zinc ion; IEA:Ensembl.
# GO_process	GO:0061088	regulation of sequestering of zinc ion; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.20.1510.10	-; 2.
# Genevisible	Q8NEW0	HS
# HGNC	HGNC:19306	SLC30A7
# INDUCTION	Increased intracellular zinc level, resulting from extracellular zinc supplementation, do not induce any up- or down- regulation of gene expression. Up-regulated by zinc depletion. {ECO:0000269|PubMed	15276077}. 
# IntAct	Q8NEW0	11
# InterPro	IPR002524	Cation_efflux
# InterPro	IPR027469	Cation_efflux_TMD
# KEGG_Brite	ko02001	Solute carrier family
# MIM	611149	gene
# Organism	ZNT7_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11562	PTHR11562; 2
# Pfam	PF01545	Cation_efflux
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-264876	Insulin processing
# Reactome	R-HSA-435368	Zinc efflux and compartmentalization by the SLC30 family
# RecName	ZNT7_HUMAN	Zinc transporter 7
# RefSeq	NP_001138356	NM_001144884.1
# RefSeq	NP_598003	NM_133496.4
# RefSeq	XP_016855889	XM_017000400.1
# SIMILARITY	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	ZNT7_HUMAN	Golgi apparatus, trans-Golgi network membrane {ECO 0000269|PubMed 12446736}; Multi-pass membrane protein {ECO 0000269|PubMed 12446736}. 
# SUBUNIT	ZNT7_HUMAN	Homooligomer. 
# TCDB	2.A.4.4	the cation diffusion facilitator (cdf) family
# TIGRFAMs	TIGR01297	CDF
# UCSC	uc001dtn	human
# eggNOG	COG1230	LUCA
# eggNOG	KOG1484	Eukaryota
BLAST	swissprot:ZNT7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ZNT7_HUMAN
BioCyc	ZFISH:ENSG00000162695-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000162695-MONOMER
COG	COG1230	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1230
COXPRESdb	148867	http://coxpresdb.jp/data/gene/148867.shtml
CleanEx	HS_SLC30A7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC30A7
DOI	10.1016/j.bcp.2004.05.024	http://dx.doi.org/10.1016/j.bcp.2004.05.024
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M207644200	http://dx.doi.org/10.1074/jbc.M207644200
DOI	10.1074/jbc.M506902200	http://dx.doi.org/10.1074/jbc.M506902200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AC104506	http://www.ebi.ac.uk/ena/data/view/AC104506
EMBL	AF233345	http://www.ebi.ac.uk/ena/data/view/AF233345
EMBL	AF529197	http://www.ebi.ac.uk/ena/data/view/AF529197
EMBL	AK313638	http://www.ebi.ac.uk/ena/data/view/AK313638
EMBL	AL732465	http://www.ebi.ac.uk/ena/data/view/AL732465
EMBL	AY094606	http://www.ebi.ac.uk/ena/data/view/AY094606
EMBL	BC064692	http://www.ebi.ac.uk/ena/data/view/BC064692
EMBL	BX537375	http://www.ebi.ac.uk/ena/data/view/BX537375
EMBL	CH471097	http://www.ebi.ac.uk/ena/data/view/CH471097
EMBL	CH471097	http://www.ebi.ac.uk/ena/data/view/CH471097
Ensembl	ENST00000357650	http://www.ensembl.org/id/ENST00000357650
Ensembl	ENST00000370112	http://www.ensembl.org/id/ENST00000370112
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0016023	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016023
GO_component	GO:0031982	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031982
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005385	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005385
GO_process	GO:0010043	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010043
GO_process	GO:0032119	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032119
GO_process	GO:0061088	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061088
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.20.1510.10	http://www.cathdb.info/version/latest/superfamily/1.20.1510.10
GeneCards	SLC30A7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC30A7
GeneID	148867	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=148867
GeneTree	ENSGT00630000089781	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00630000089781
HGNC	HGNC:19306	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:19306
HOGENOM	HOG000018690	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000018690&db=HOGENOM6
HOVERGEN	HBG056637	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG056637&db=HOVERGEN
HPA	HPA018034	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA018034
InParanoid	Q8NEW0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8NEW0
IntAct	Q8NEW0	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8NEW0*
InterPro	IPR002524	http://www.ebi.ac.uk/interpro/entry/IPR002524
InterPro	IPR027469	http://www.ebi.ac.uk/interpro/entry/IPR027469
Jabion	148867	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=148867
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:148867	http://www.genome.jp/dbget-bin/www_bget?hsa:148867
KEGG_Orthology	KO:K14692	http://www.genome.jp/dbget-bin/www_bget?KO:K14692
MIM	611149	http://www.ncbi.nlm.nih.gov/omim/611149
MINT	MINT-4723925	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4723925
OMA	NEKYSYG	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NEKYSYG
OrthoDB	EOG091G030D	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G030D
PANTHER	PTHR11562	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11562
PSORT	swissprot:ZNT7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ZNT7_HUMAN
PSORT-B	swissprot:ZNT7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ZNT7_HUMAN
PSORT2	swissprot:ZNT7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ZNT7_HUMAN
Pfam	PF01545	http://pfam.xfam.org/family/PF01545
PharmGKB	PA134891595	http://www.pharmgkb.org/do/serve?objId=PA134891595&objCls=Gene
Phobius	swissprot:ZNT7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ZNT7_HUMAN
PhylomeDB	Q8NEW0	http://phylomedb.org/?seqid=Q8NEW0
ProteinModelPortal	Q8NEW0	http://www.proteinmodelportal.org/query/uniprot/Q8NEW0
PubMed	12446736	http://www.ncbi.nlm.nih.gov/pubmed/12446736
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15276077	http://www.ncbi.nlm.nih.gov/pubmed/15276077
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15994300	http://www.ncbi.nlm.nih.gov/pubmed/15994300
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
Reactome	R-HSA-264876	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-264876
Reactome	R-HSA-435368	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-435368
RefSeq	NP_001138356	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001138356
RefSeq	NP_598003	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_598003
RefSeq	XP_016855889	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016855889
STRING	9606.ENSP00000350278	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000350278&targetmode=cogs
STRING	COG1230	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1230&targetmode=cogs
TCDB	2.A.4.4	http://www.tcdb.org/search/result.php?tc=2.A.4.4
TIGRFAMs	TIGR01297	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01297
UCSC	uc001dtn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001dtn&org=rat
UniGene	Hs.533903	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.533903
UniProtKB	ZNT7_HUMAN	http://www.uniprot.org/uniprot/ZNT7_HUMAN
UniProtKB-AC	Q8NEW0	http://www.uniprot.org/uniprot/Q8NEW0
charge	swissprot:ZNT7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ZNT7_HUMAN
eggNOG	COG1230	http://eggnogapi.embl.de/nog_data/html/tree/COG1230
eggNOG	KOG1484	http://eggnogapi.embl.de/nog_data/html/tree/KOG1484
epestfind	swissprot:ZNT7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ZNT7_HUMAN
garnier	swissprot:ZNT7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ZNT7_HUMAN
helixturnhelix	swissprot:ZNT7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZNT7_HUMAN
hmoment	swissprot:ZNT7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ZNT7_HUMAN
iep	swissprot:ZNT7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ZNT7_HUMAN
inforesidue	swissprot:ZNT7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ZNT7_HUMAN
neXtProt	NX_Q8NEW0	http://www.nextprot.org/db/entry/NX_Q8NEW0
octanol	swissprot:ZNT7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ZNT7_HUMAN
pepcoil	swissprot:ZNT7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ZNT7_HUMAN
pepdigest	swissprot:ZNT7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ZNT7_HUMAN
pepinfo	swissprot:ZNT7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ZNT7_HUMAN
pepnet	swissprot:ZNT7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ZNT7_HUMAN
pepstats	swissprot:ZNT7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ZNT7_HUMAN
pepwheel	swissprot:ZNT7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ZNT7_HUMAN
pepwindow	swissprot:ZNT7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ZNT7_HUMAN
sigcleave	swissprot:ZNT7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ZNT7_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	106994	174
# CATALYTIC ACTIVITY	ATPB_HUMAN	ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out). 
# ChiTaRS	ATP5B	human
# Ensembl	ENST00000262030	ENSP00000262030; ENSG00000110955
# ExpressionAtlas	P06576	baseline and differential
# FUNCTION	ATPB_HUMAN	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. 
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005753	mitochondrial proton-transporting ATP synthase complex; IDA:UniProtKB.
# GO_component	GO:0005754	mitochondrial proton-transporting ATP synthase, catalytic core; NAS:UniProtKB.
# GO_component	GO:0005759	mitochondrial matrix; NAS:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0009986	cell surface; IDA:UniProtKB.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0031012	extracellular matrix; IDA:BHF-UCL.
# GO_component	GO:0031966	mitochondrial membrane; IDA:UniProtKB.
# GO_component	GO:0042645	mitochondrial nucleoid; IDA:BHF-UCL.
# GO_component	GO:0043209	myelin sheath; IEA:Ensembl.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005215	transporter activity; NAS:UniProtKB.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0022857	transmembrane transporter activity; IC:UniProtKB.
# GO_function	GO:0042288	MHC class I protein binding; IDA:UniProtKB.
# GO_function	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism; IEA:InterPro.
# GO_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism; IMP:UniProtKB.
# GO_process	GO:0001525	angiogenesis; IMP:UniProtKB.
# GO_process	GO:0001649	osteoblast differentiation; IDA:UniProtKB.
# GO_process	GO:0006091	generation of precursor metabolites and energy; NAS:UniProtKB.
# GO_process	GO:0006629	lipid metabolic process; IEA:Ensembl.
# GO_process	GO:0006754	ATP biosynthetic process; IMP:UniProtKB.
# GO_process	GO:0006933	negative regulation of cell adhesion involved in substrate-bound cell migration; IEA:Ensembl.
# GO_process	GO:0007005	mitochondrion organization; TAS:Reactome.
# GO_process	GO:0015992	proton transport; IMP:UniProtKB.
# GO_process	GO:0042776	mitochondrial ATP synthesis coupled proton transport; IC:UniProtKB.
# GO_process	GO:0051453	regulation of intracellular pH; IMP:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006091	generation of precursor metabolites and energy
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007005	mitochondrion organization
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0048646	anatomical structure formation involved in morphogenesis
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.10.1140.10	-; 1.
# Gene3D	3.40.50.300	-; 1.
# Genevisible	P06576	HS
# HAMAP	MF_01347	ATP_synth_beta_bact
# HGNC	HGNC:830	ATP5B
# INTERACTION	ATPB_HUMAN	P63104 YWHAZ; NbExp=2; IntAct=EBI-356231, EBI-347088; 
# IntAct	P06576	60
# InterPro	IPR000194	ATPase_F1/V1/A1_a/bsu_nucl-bd
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR004100	ATPase_F1/V1/A1_a/bsu_N
# InterPro	IPR005722	ATP_synth_F1_bsu
# InterPro	IPR020003	ATPase_a/bsu_AS
# InterPro	IPR024034	ATPase_F1/V1_bsu_C
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# MIM	102910	gene
# Organism	ATPB_HUMAN	Homo sapiens (Human)
# PIR	A33370	A33370
# PROSITE	PS00152	ATPASE_ALPHA_BETA
# Pfam	PF00006	ATP-synt_ab
# Pfam	PF02874	ATP-synt_ab_N
# Proteomes	UP000005640	Chromosome 12
# Reactome	R-HSA-1268020	Mitochondrial protein import
# Reactome	R-HSA-163210	Formation of ATP by chemiosmotic coupling
# Reactome	R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis
# RecName	ATPB_HUMAN	ATP synthase subunit beta, mitochondrial
# RefSeq	NP_001677	NM_001686.3
# SIMILARITY	Belongs to the ATPase alpha/beta chains family. {ECO	0000305}.
# SMART	SM00382	AAA
# SUBCELLULAR LOCATION	ATPB_HUMAN	Mitochondrion. Mitochondrion inner membrane. Note=Peripheral membrane protein. 
# SUBUNIT	ATPB_HUMAN	F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits  alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits  a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68. Interacts with PPIF. Interacts with BCL2L1 isoform BCL-X(L); the interaction mediates the association of BCL2L1 isoform BCL-X(L) with the mitochondrial membrane F(1)F(0) ATP synthase and enhances neurons metabolic efficency. Interacts with CLN5 and PPT1. {ECO 0000250|UniProtKB P00829, ECO 0000250|UniProtKB P10719, ECO 0000250|UniProtKB P56480}. 
# SUPFAM	SSF50615	SSF50615
# SUPFAM	SSF52540	SSF52540
# TIGRFAMs	TIGR01039	atpD
# eggNOG	COG0055	LUCA
# eggNOG	KOG1350	Eukaryota
BLAST	swissprot:ATPB_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ATPB_HUMAN
BioCyc	ZFISH:HS03358-MONOMER	http://biocyc.org/getid?id=ZFISH:HS03358-MONOMER
COG	COG0055	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0055
COXPRESdb	506	http://coxpresdb.jp/data/gene/506.shtml
CleanEx	HS_ATP5B	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP5B
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1007/BF00434661	http://dx.doi.org/10.1007/BF00434661
DOI	10.1016/0888-7543(89)90125-0	http://dx.doi.org/10.1016/0888-7543(89)90125-0
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/BJ20040647	http://dx.doi.org/10.1042/BJ20040647
DOI	10.1073/pnas.0908958106	http://dx.doi.org/10.1073/pnas.0908958106
DOI	10.1073/pnas.1503696112	http://dx.doi.org/10.1073/pnas.1503696112
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EC_number	EC:3.6.3.14	http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.14
EMBL	AK291085	http://www.ebi.ac.uk/ena/data/view/AK291085
EMBL	BC016512	http://www.ebi.ac.uk/ena/data/view/BC016512
EMBL	CH471054	http://www.ebi.ac.uk/ena/data/view/CH471054
EMBL	D00022	http://www.ebi.ac.uk/ena/data/view/D00022
EMBL	M19482	http://www.ebi.ac.uk/ena/data/view/M19482
EMBL	M19483	http://www.ebi.ac.uk/ena/data/view/M19483
EMBL	M27132	http://www.ebi.ac.uk/ena/data/view/M27132
EMBL	X03559	http://www.ebi.ac.uk/ena/data/view/X03559
EMBL	X05606	http://www.ebi.ac.uk/ena/data/view/X05606
ENZYME	3.6.3.14	http://enzyme.expasy.org/EC/3.6.3.14
Ensembl	ENST00000262030	http://www.ensembl.org/id/ENST00000262030
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005753	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005753
GO_component	GO:0005754	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005754
GO_component	GO:0005759	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005759
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0031012	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031012
GO_component	GO:0031966	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031966
GO_component	GO:0042645	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042645
GO_component	GO:0043209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043209
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GO_function	GO:0042288	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042288
GO_function	GO:0046933	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046933
GO_function	GO:0046961	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046961
GO_process	GO:0001525	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001525
GO_process	GO:0001649	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001649
GO_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GO_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GO_process	GO:0006754	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006754
GO_process	GO:0006933	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006933
GO_process	GO:0007005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007005
GO_process	GO:0015992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992
GO_process	GO:0042776	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042776
GO_process	GO:0051453	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007005
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0048646	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048646
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.10.1140.10	http://www.cathdb.info/version/latest/superfamily/1.10.1140.10
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ATP5B	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP5B
GeneID	506	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=506
GeneTree	ENSGT00550000074800	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074800
HAMAP	MF_01347	http://hamap.expasy.org/unirule/MF_01347
HGNC	HGNC:830	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:830
HOGENOM	HOG000009605	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009605&db=HOGENOM6
HOVERGEN	HBG004307	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG004307&db=HOVERGEN
HPA	CAB017527	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB017527
HPA	HPA001520	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA001520
HPA	HPA001528	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA001528
InParanoid	P06576	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06576
IntAct	P06576	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06576*
IntEnz	3.6.3.14	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.14
InterPro	IPR000194	http://www.ebi.ac.uk/interpro/entry/IPR000194
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR004100	http://www.ebi.ac.uk/interpro/entry/IPR004100
InterPro	IPR005722	http://www.ebi.ac.uk/interpro/entry/IPR005722
InterPro	IPR020003	http://www.ebi.ac.uk/interpro/entry/IPR020003
InterPro	IPR024034	http://www.ebi.ac.uk/interpro/entry/IPR024034
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	506	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=506
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:506	http://www.genome.jp/dbget-bin/www_bget?hsa:506
KEGG_Orthology	KO:K02133	http://www.genome.jp/dbget-bin/www_bget?KO:K02133
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
MIM	102910	http://www.ncbi.nlm.nih.gov/omim/102910
MINT	MINT-5004016	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5004016
OMA	AEFGIYP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AEFGIYP
OrthoDB	EOG091G0KVV	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0KVV
PROSITE	PS00152	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00152
PSORT	swissprot:ATPB_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ATPB_HUMAN
PSORT-B	swissprot:ATPB_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ATPB_HUMAN
PSORT2	swissprot:ATPB_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ATPB_HUMAN
Pfam	PF00006	http://pfam.xfam.org/family/PF00006
Pfam	PF02874	http://pfam.xfam.org/family/PF02874
PharmGKB	PA25122	http://www.pharmgkb.org/do/serve?objId=PA25122&objCls=Gene
Phobius	swissprot:ATPB_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ATPB_HUMAN
PhylomeDB	P06576	http://phylomedb.org/?seqid=P06576
ProteinModelPortal	P06576	http://www.proteinmodelportal.org/query/uniprot/P06576
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15242332	http://www.ncbi.nlm.nih.gov/pubmed/15242332
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	19892738	http://www.ncbi.nlm.nih.gov/pubmed/19892738
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25787250	http://www.ncbi.nlm.nih.gov/pubmed/25787250
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	2687158	http://www.ncbi.nlm.nih.gov/pubmed/2687158
PubMed	2870059	http://www.ncbi.nlm.nih.gov/pubmed/2870059
PubMed	2896550	http://www.ncbi.nlm.nih.gov/pubmed/2896550
PubMed	2900241	http://www.ncbi.nlm.nih.gov/pubmed/2900241
Reactome	R-HSA-1268020	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1268020
Reactome	R-HSA-163210	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-163210
Reactome	R-HSA-2151201	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2151201
RefSeq	NP_001677	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001677
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMR	P06576	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06576
STRING	9606.ENSP00000262030	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000262030&targetmode=cogs
STRING	COG0055	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0055&targetmode=cogs
SUPFAM	SSF50615	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50615
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
SWISS-2DPAGE	P06576	http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P06576
TIGRFAMs	TIGR01039	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01039
UniGene	Hs.406510	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.406510
UniProtKB	ATPB_HUMAN	http://www.uniprot.org/uniprot/ATPB_HUMAN
UniProtKB-AC	P06576	http://www.uniprot.org/uniprot/P06576
charge	swissprot:ATPB_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ATPB_HUMAN
eggNOG	COG0055	http://eggnogapi.embl.de/nog_data/html/tree/COG0055
eggNOG	KOG1350	http://eggnogapi.embl.de/nog_data/html/tree/KOG1350
epestfind	swissprot:ATPB_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ATPB_HUMAN
garnier	swissprot:ATPB_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ATPB_HUMAN
helixturnhelix	swissprot:ATPB_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATPB_HUMAN
hmoment	swissprot:ATPB_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ATPB_HUMAN
iep	swissprot:ATPB_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ATPB_HUMAN
inforesidue	swissprot:ATPB_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ATPB_HUMAN
neXtProt	NX_P06576	http://www.nextprot.org/db/entry/NX_P06576
octanol	swissprot:ATPB_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ATPB_HUMAN
pepcoil	swissprot:ATPB_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ATPB_HUMAN
pepdigest	swissprot:ATPB_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ATPB_HUMAN
pepinfo	swissprot:ATPB_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ATPB_HUMAN
pepnet	swissprot:ATPB_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ATPB_HUMAN
pepstats	swissprot:ATPB_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ATPB_HUMAN
pepwheel	swissprot:ATPB_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ATPB_HUMAN
pepwindow	swissprot:ATPB_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ATPB_HUMAN
sigcleave	swissprot:ATPB_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ATPB_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AT2C2_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O75185-1; Sequence=Displayed; Name=2; IsoId=O75185-2; Sequence=VSP_035989; Note=Ref.2 (BAA31678) sequence is in conflict in position  12 R->I. {ECO 0000305}; Name=3; IsoId=O75185-3; Sequence=VSP_054679; Note=No experimental confirmation available. Ref.4 (CAI46049) sequence is in conflict in position  789 A->G. {ECO 0000305}; 
# AltName	AT2C2_HUMAN	Secretory pathway Ca(2+)-ATPase 2
# BRENDA	3.6.3	2681
# CATALYTIC ACTIVITY	AT2C2_HUMAN	ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2). 
# CCDS	CCDS42207	-. [O75185-1]
# CCDS	CCDS67088	-. [O75185-3]
# ChiTaRS	ATP2C2	human
# Ensembl	ENST00000262429	ENSP00000262429; ENSG00000064270
# ExpressionAtlas	O75185	baseline and differential
# FUNCTION	AT2C2_HUMAN	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. {ECO 0000250}. 
# GO_component	GO:0000139	Golgi membrane; IBA:GO_Central.
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0005388	calcium-transporting ATPase activity; IBA:GO_Central.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0015410	manganese-transporting ATPase activity; IBA:GO_Central.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0006874	cellular calcium ion homeostasis; IBA:GO_Central.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.20.1110.10	-; 3.
# Genevisible	O75185	HS
# HGNC	HGNC:29103	ATP2C2
# INTERACTION	AT2C2_HUMAN	Q96D31 ORAI1; NbExp=10; IntAct=EBI-2939806, EBI-2291476; 
# InterPro	IPR001757	P_typ_ATPase
# InterPro	IPR004014	ATPase_P-typ_cation-transptr_N
# InterPro	IPR006068	ATPase_P-typ_cation-transptr_C
# InterPro	IPR006413	P-type_ATPase_IIA_PMR1
# InterPro	IPR008250	ATPase_P-typ_transduc_dom_A
# InterPro	IPR018303	ATPase_P-typ_P_site
# InterPro	IPR023214	HAD-like_dom
# InterPro	IPR023298	ATPase_P-typ_TM_dom
# InterPro	IPR023299	ATPase_P-typ_cyto_domN
# InterPro	IPR030334	ATP2C2
# KEGG_Brite	ko01000	Enzymes
# MIM	613082	gene
# Organism	AT2C2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR24093:SF220	PTHR24093:SF220
# PRINTS	PR00120	HATPASE
# PROSITE	PS00154	ATPASE_E1_E2
# Pfam	PF00122	E1-E2_ATPase
# Pfam	PF00689	Cation_ATPase_C
# Pfam	PF00690	Cation_ATPase_N
# Proteomes	UP000005640	Chromosome 16
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	AT2C2_HUMAN	Calcium-transporting ATPase type 2C member 2
# RefSeq	NP_001273456	NM_001286527.2
# RefSeq	NP_001278383	NM_001291454.1
# RefSeq	NP_055676	NM_014861.3
# SEQUENCE CAUTION	Sequence=BAA31678.2; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. {ECO	0000305}. 
# SMART	SM00831	Cation_ATPase_N
# SUBCELLULAR LOCATION	AT2C2_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF56784	SSF56784; 2
# SUPFAM	SSF81660	SSF81660
# TCDB	3.A.3.2	the p-type atpase (p-atpase) superfamily
# TIGRFAMs	TIGR01494	ATPase_P-type; 2
# TIGRFAMs	TIGR01522	ATPase-IIA2_Ca
# UCSC	uc002fhx	human. [O75185-1]
# eggNOG	COG0474	LUCA
# eggNOG	KOG0202	Eukaryota
BLAST	swissprot:AT2C2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AT2C2_HUMAN
BioCyc	ZFISH:HS00799-MONOMER	http://biocyc.org/getid?id=ZFISH:HS00799-MONOMER
COG	COG0474	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0474
COXPRESdb	9914	http://coxpresdb.jp/data/gene/9914.shtml
CleanEx	HS_ATP2C2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP2C2
DOI	10.1038/nature03187	http://dx.doi.org/10.1038/nature03187
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/jbc.M501026200	http://dx.doi.org/10.1074/jbc.M501026200
DOI	10.1093/dnares/5.3.169	http://dx.doi.org/10.1093/dnares/5.3.169
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EC_number	EC:3.6.3.8	http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.8
EMBL	AB014603	http://www.ebi.ac.uk/ena/data/view/AB014603
EMBL	AC010551	http://www.ebi.ac.uk/ena/data/view/AC010551
EMBL	AC022165	http://www.ebi.ac.uk/ena/data/view/AC022165
EMBL	AK300526	http://www.ebi.ac.uk/ena/data/view/AK300526
EMBL	AY791884	http://www.ebi.ac.uk/ena/data/view/AY791884
EMBL	BX648333	http://www.ebi.ac.uk/ena/data/view/BX648333
EMBL	CR749829	http://www.ebi.ac.uk/ena/data/view/CR749829
ENZYME	3.6.3.8	http://enzyme.expasy.org/EC/3.6.3.8
Ensembl	ENST00000262429	http://www.ensembl.org/id/ENST00000262429
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0005388	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005388
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0015410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015410
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006874	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.20.1110.10	http://www.cathdb.info/version/latest/superfamily/1.20.1110.10
GeneCards	ATP2C2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP2C2
GeneID	9914	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9914
H-InvDB	HIX0013295	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0013295
H-InvDB	HIX0013296	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0013296
HGNC	HGNC:29103	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:29103
HOGENOM	HOG000265621	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265621&db=HOGENOM6
HOVERGEN	HBG106478	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG106478&db=HOVERGEN
HPA	HPA052262	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA052262
InParanoid	O75185	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O75185
IntAct	O75185	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O75185*
IntEnz	3.6.3.8	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.8
InterPro	IPR001757	http://www.ebi.ac.uk/interpro/entry/IPR001757
InterPro	IPR004014	http://www.ebi.ac.uk/interpro/entry/IPR004014
InterPro	IPR006068	http://www.ebi.ac.uk/interpro/entry/IPR006068
InterPro	IPR006413	http://www.ebi.ac.uk/interpro/entry/IPR006413
InterPro	IPR008250	http://www.ebi.ac.uk/interpro/entry/IPR008250
InterPro	IPR018303	http://www.ebi.ac.uk/interpro/entry/IPR018303
InterPro	IPR023214	http://www.ebi.ac.uk/interpro/entry/IPR023214
InterPro	IPR023298	http://www.ebi.ac.uk/interpro/entry/IPR023298
InterPro	IPR023299	http://www.ebi.ac.uk/interpro/entry/IPR023299
InterPro	IPR030334	http://www.ebi.ac.uk/interpro/entry/IPR030334
Jabion	9914	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=9914
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:9914	http://www.genome.jp/dbget-bin/www_bget?hsa:9914
KEGG_Orthology	KO:K01537	http://www.genome.jp/dbget-bin/www_bget?KO:K01537
MIM	613082	http://www.ncbi.nlm.nih.gov/omim/613082
PANTHER	PTHR24093:SF220	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24093:SF220
PRINTS	PR00120	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00120
PROSITE	PS00154	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00154
PSORT	swissprot:AT2C2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AT2C2_HUMAN
PSORT-B	swissprot:AT2C2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AT2C2_HUMAN
PSORT2	swissprot:AT2C2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AT2C2_HUMAN
Pfam	PF00122	http://pfam.xfam.org/family/PF00122
Pfam	PF00689	http://pfam.xfam.org/family/PF00689
Pfam	PF00690	http://pfam.xfam.org/family/PF00690
PharmGKB	PA162377204	http://www.pharmgkb.org/do/serve?objId=PA162377204&objCls=Gene
Phobius	swissprot:AT2C2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AT2C2_HUMAN
PhylomeDB	O75185	http://phylomedb.org/?seqid=O75185
ProteinModelPortal	O75185	http://www.proteinmodelportal.org/query/uniprot/O75185
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15616553	http://www.ncbi.nlm.nih.gov/pubmed/15616553
PubMed	15831496	http://www.ncbi.nlm.nih.gov/pubmed/15831496
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	9734811	http://www.ncbi.nlm.nih.gov/pubmed/9734811
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_001273456	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273456
RefSeq	NP_001278383	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001278383
RefSeq	NP_055676	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055676
SMART	SM00831	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00831
SMR	O75185	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O75185
STRING	9606.ENSP00000262429	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000262429&targetmode=cogs
STRING	COG0474	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0474&targetmode=cogs
SUPFAM	SSF56784	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784
SUPFAM	SSF81660	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81660
TCDB	3.A.3.2	http://www.tcdb.org/search/result.php?tc=3.A.3.2
TIGRFAMs	TIGR01494	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01494
TIGRFAMs	TIGR01522	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01522
UCSC	uc002fhx	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002fhx&org=rat
UniGene	Hs.6168	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.6168
UniProtKB	AT2C2_HUMAN	http://www.uniprot.org/uniprot/AT2C2_HUMAN
UniProtKB-AC	O75185	http://www.uniprot.org/uniprot/O75185
charge	swissprot:AT2C2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AT2C2_HUMAN
eggNOG	COG0474	http://eggnogapi.embl.de/nog_data/html/tree/COG0474
eggNOG	KOG0202	http://eggnogapi.embl.de/nog_data/html/tree/KOG0202
epestfind	swissprot:AT2C2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AT2C2_HUMAN
garnier	swissprot:AT2C2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AT2C2_HUMAN
helixturnhelix	swissprot:AT2C2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AT2C2_HUMAN
hmoment	swissprot:AT2C2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AT2C2_HUMAN
iep	swissprot:AT2C2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AT2C2_HUMAN
inforesidue	swissprot:AT2C2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AT2C2_HUMAN
neXtProt	NX_O75185	http://www.nextprot.org/db/entry/NX_O75185
octanol	swissprot:AT2C2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AT2C2_HUMAN
pepcoil	swissprot:AT2C2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AT2C2_HUMAN
pepdigest	swissprot:AT2C2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AT2C2_HUMAN
pepinfo	swissprot:AT2C2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AT2C2_HUMAN
pepnet	swissprot:AT2C2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AT2C2_HUMAN
pepstats	swissprot:AT2C2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AT2C2_HUMAN
pepwheel	swissprot:AT2C2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AT2C2_HUMAN
pepwindow	swissprot:AT2C2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AT2C2_HUMAN
sigcleave	swissprot:AT2C2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AT2C2_HUMAN
## Database	ID	URL or Descriptions
# AltName	CAC1S_HUMAN	Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle
# AltName	CAC1S_HUMAN	Voltage-gated calcium channel subunit alpha Cav1.1
# BioGrid	107233	4
# DISEASE	CAC1S_HUMAN	Malignant hyperthermia 5 (MHS5) [MIM 601887]  Autosomal dominant disorder that is potentially lethal in susceptible individuals on exposure to commonly used inhalational anesthetics and depolarizing muscle relaxants. {ECO 0000269|PubMed 9199552}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# DISEASE	CAC1S_HUMAN	Periodic paralysis hypokalemic 1 (HOKPP1) [MIM 170400]  An autosomal dominant disorder manifested by episodic flaccid generalized muscle weakness associated with falls of serum potassium levels. {ECO 0000269|PubMed 17418573, ECO 0000269|PubMed 18162704, ECO 0000269|PubMed 19118277, ECO 0000269|PubMed 7987325, ECO 0000269|PubMed 8004673}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	CAC1S_HUMAN	Thyrotoxic periodic paralysis 1 (TTPP1) [MIM 188580]  A sporadic muscular disorder characterized by episodic weakness and hypokalemia during a thyrotoxic state. It is clinically similar to hereditary hypokalemic periodic paralysis, except for the fact that hyperthyroidism is an absolute requirement for disease manifestation. The disease presents with recurrent episodes of acute muscular weakness of the four extremities that vary in severity from paresis to complete paralysis. Attacks are triggered by ingestion of a high carbohydrate load or strenuous physical activity followed by a period of rest. Thyrotoxic periodic paralysis can occur in association with any cause of hyperthyroidism, but is most commonly associated with Graves disease. {ECO 0000269|PubMed 15001631}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 
# DOMAIN	CAC1S_HUMAN	Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position. 
# DOMAIN	CAC1S_HUMAN	The loop between repeats II and III interacts with the ryanodine receptor, and is therefore important for calcium release from the endoplasmic reticulum necessary for muscle contraction. 
# DrugBank	DB00270	Isradipine
# DrugBank	DB00381	Amlodipine
# DrugBank	DB00393	Nimodipine
# DrugBank	DB00401	Nisoldipine
# DrugBank	DB00421	Spironolactone
# DrugBank	DB00568	Cinnarizine
# DrugBank	DB00653	Magnesium Sulfate
# DrugBank	DB00661	Verapamil
# DrugBank	DB00898	Ethanol
# DrugBank	DB01023	Felodipine
# DrugBank	DB01054	Nitrendipine
# DrugBank	DB01115	Nifedipine
# DrugBank	DB04855	Dronedarone
# DrugBank	DB04920	Clevidipine
# DrugBank	DB06712	Nilvadipine
# Ensembl	ENST00000362061	ENSP00000355192; ENSG00000081248
# ExpressionAtlas	Q13698	baseline and differential
# FUNCTION	CAC1S_HUMAN	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle. 
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0005891	voltage-gated calcium channel complex; IDA:UniProtKB.
# GO_component	GO:0030315	T-tubule; IDA:UniProtKB.
# GO_component	GO:0031674	I band; IDA:UniProtKB.
# GO_function	GO:0005245	voltage-gated calcium channel activity; IDA:UniProtKB.
# GO_function	GO:0008331	high voltage-gated calcium channel activity; IDA:UniProtKB.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_process	GO:0006816	calcium ion transport; IDA:UniProtKB.
# GO_process	GO:0006936	muscle contraction; IMP:UniProtKB.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:0086010	membrane depolarization during action potential; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.20.120.350	-; 4.
# Genevisible	Q13698	HS
# HGNC	HGNC:1397	CACNA1S
# INTERACTION	CAC1S_HUMAN	Q86UT5 PDZD3; NbExp=3; IntAct=EBI-5329490, EBI-8744528; 
# IntAct	Q13698	6
# InterPro	IPR002077	VDCCAlpha1
# InterPro	IPR005446	VDCC_L_a1su
# InterPro	IPR005450	VDCC_L_a1ssu
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR014873	VDCC_a1su_IQ
# InterPro	IPR027359	Channel_four-helix_dom
# InterPro	IPR031649	GPHH_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00215:[Inherited metabolic disease; Nervous system disease; Muscular disease] Andersen-Tawil syndrome (ATS) [DS	H00748]
# KEGG_Disease	H00746	[Musculoskeletal disease; Nervous system disease; Inherited metabolic disease] Hypokalemic periodic paralysis (HypoPP)
# KEGG_Pathway	ko04010	MAPK signaling pathway
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko04270	Vascular smooth muscle contraction
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04725	Cholinergic synapse
# KEGG_Pathway	ko04726	Serotonergic synapse
# KEGG_Pathway	ko04727	GABAergic synapse
# KEGG_Pathway	ko04912	GnRH signaling pathway
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05410	Hypertrophic cardiomyopathy (HCM)
# KEGG_Pathway	ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
# KEGG_Pathway	ko05414	Dilated cardiomyopathy
# MIM	114208	gene
# MIM	170400	phenotype
# MIM	188580	phenotype
# MIM	601887	phenotype
# Organism	CAC1S_HUMAN	Homo sapiens (Human)
# Orphanet	397755	Periodic paralysis with transient compartment-like syndrome
# Orphanet	423	Malignant hyperthermia
# Orphanet	681	Hypokalemic periodic paralysis
# Orphanet	79102	Thyrotoxic periodic paralysis
# PANTHER	PTHR10037:SF190	PTHR10037:SF190; 2
# PDB	2VAY	X-ray; 1.94 A; B=1522-1542
# PIR	A55645	A55645
# PIR	I38611	I38611
# PRINTS	PR00167	CACHANNEL
# PRINTS	PR01630	LVDCCALPHA1
# PRINTS	PR01634	LVDCCALPHA1S
# PTM	CAC1S_HUMAN	Phosphorylation by PKA activates the calcium channel. {ECO 0000250}. 
# Pfam	PF00520	Ion_trans; 4
# Pfam	PF08763	Ca_chan_IQ
# Pfam	PF16905	GPHH
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-419037	NCAM1 interactions
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# Reactome	R-HSA-5576893	Phase 2 - plateau phase
# Reactome	R-HSA-5576894	Phase 1 - inactivation of fast Na+ channels
# RecName	CAC1S_HUMAN	Voltage-dependent L-type calcium channel subunit alpha-1S
# RefSeq	NP_000060	NM_000069.2
# SIMILARITY	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1S subfamily. {ECO	0000305}.
# SMART	SM01062	Ca_chan_IQ
# SUBCELLULAR LOCATION	CAC1S_HUMAN	Membrane; Multi-pass membrane protein. 
# SUBUNIT	CAC1S_HUMAN	Multisubunit complex consisting of alpha-1, alpha-2, beta and delta subunits in a 1 1 1 1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. An additional gamma subunit is present only in skeletal muscle L-type channel. Interacts with DYSF and JSRP1. Interacts with RYR1 (By similarity). {ECO 0000250}. 
# TISSUE SPECIFICITY	CAC1S_HUMAN	Skeletal muscle specific. 
# UCSC	uc001gvv	human
# eggNOG	ENOG410XNP6	LUCA
# eggNOG	KOG2301	Eukaryota
BLAST	swissprot:CAC1S_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CAC1S_HUMAN
BioCyc	ZFISH:ENSG00000081248-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000081248-MONOMER
COXPRESdb	779	http://coxpresdb.jp/data/gene/779.shtml
CleanEx	HS_CACNA1S	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CACNA1S
DOI	10.1006/geno.1993.1017	http://dx.doi.org/10.1006/geno.1993.1017
DOI	10.1006/geno.1994.1677	http://dx.doi.org/10.1006/geno.1994.1677
DOI	10.1006/geno.1996.0066	http://dx.doi.org/10.1006/geno.1996.0066
DOI	10.1016/0092-8674(94)90135-X	http://dx.doi.org/10.1016/0092-8674(94)90135-X
DOI	10.1016/j.nmd.2007.01.020	http://dx.doi.org/10.1016/j.nmd.2007.01.020
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1086/515454	http://dx.doi.org/10.1086/515454
DOI	10.1093/hmg/3.8.1415	http://dx.doi.org/10.1093/hmg/3.8.1415
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1210/jc.2003-030924	http://dx.doi.org/10.1210/jc.2003-030924
DOI	10.1212/01.wnl.0000342387.65477.46	http://dx.doi.org/10.1212/01.wnl.0000342387.65477.46
DOI	10.3346/jkms.2007.22.6.946	http://dx.doi.org/10.3346/jkms.2007.22.6.946
DrugBank	DB00270	http://www.drugbank.ca/drugs/DB00270
DrugBank	DB00381	http://www.drugbank.ca/drugs/DB00381
DrugBank	DB00393	http://www.drugbank.ca/drugs/DB00393
DrugBank	DB00401	http://www.drugbank.ca/drugs/DB00401
DrugBank	DB00421	http://www.drugbank.ca/drugs/DB00421
DrugBank	DB00568	http://www.drugbank.ca/drugs/DB00568
DrugBank	DB00653	http://www.drugbank.ca/drugs/DB00653
DrugBank	DB00661	http://www.drugbank.ca/drugs/DB00661
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01023	http://www.drugbank.ca/drugs/DB01023
DrugBank	DB01054	http://www.drugbank.ca/drugs/DB01054
DrugBank	DB01115	http://www.drugbank.ca/drugs/DB01115
DrugBank	DB04855	http://www.drugbank.ca/drugs/DB04855
DrugBank	DB04920	http://www.drugbank.ca/drugs/DB04920
DrugBank	DB06712	http://www.drugbank.ca/drugs/DB06712
EMBL	AL139159	http://www.ebi.ac.uk/ena/data/view/AL139159
EMBL	AL139159	http://www.ebi.ac.uk/ena/data/view/AL139159
EMBL	AL358473	http://www.ebi.ac.uk/ena/data/view/AL358473
EMBL	AL358473	http://www.ebi.ac.uk/ena/data/view/AL358473
EMBL	BC133671	http://www.ebi.ac.uk/ena/data/view/BC133671
EMBL	L33798	http://www.ebi.ac.uk/ena/data/view/L33798
EMBL	M87486	http://www.ebi.ac.uk/ena/data/view/M87486
EMBL	M87487	http://www.ebi.ac.uk/ena/data/view/M87487
EMBL	M87488	http://www.ebi.ac.uk/ena/data/view/M87488
EMBL	U09784	http://www.ebi.ac.uk/ena/data/view/U09784
EMBL	U30666	http://www.ebi.ac.uk/ena/data/view/U30666
EMBL	U30667	http://www.ebi.ac.uk/ena/data/view/U30667
EMBL	U30668	http://www.ebi.ac.uk/ena/data/view/U30668
EMBL	U30669	http://www.ebi.ac.uk/ena/data/view/U30669
EMBL	U30670	http://www.ebi.ac.uk/ena/data/view/U30670
EMBL	U30671	http://www.ebi.ac.uk/ena/data/view/U30671
EMBL	U30672	http://www.ebi.ac.uk/ena/data/view/U30672
EMBL	U30673	http://www.ebi.ac.uk/ena/data/view/U30673
EMBL	U30674	http://www.ebi.ac.uk/ena/data/view/U30674
EMBL	U30675	http://www.ebi.ac.uk/ena/data/view/U30675
EMBL	U30676	http://www.ebi.ac.uk/ena/data/view/U30676
EMBL	U30677	http://www.ebi.ac.uk/ena/data/view/U30677
EMBL	U30678	http://www.ebi.ac.uk/ena/data/view/U30678
EMBL	U30679	http://www.ebi.ac.uk/ena/data/view/U30679
EMBL	U30680	http://www.ebi.ac.uk/ena/data/view/U30680
EMBL	U30681	http://www.ebi.ac.uk/ena/data/view/U30681
EMBL	U30682	http://www.ebi.ac.uk/ena/data/view/U30682
EMBL	U30683	http://www.ebi.ac.uk/ena/data/view/U30683
EMBL	U30684	http://www.ebi.ac.uk/ena/data/view/U30684
EMBL	U30685	http://www.ebi.ac.uk/ena/data/view/U30685
EMBL	U30686	http://www.ebi.ac.uk/ena/data/view/U30686
EMBL	U30687	http://www.ebi.ac.uk/ena/data/view/U30687
EMBL	U30688	http://www.ebi.ac.uk/ena/data/view/U30688
EMBL	U30689	http://www.ebi.ac.uk/ena/data/view/U30689
EMBL	U30690	http://www.ebi.ac.uk/ena/data/view/U30690
EMBL	U30691	http://www.ebi.ac.uk/ena/data/view/U30691
EMBL	U30692	http://www.ebi.ac.uk/ena/data/view/U30692
EMBL	U30693	http://www.ebi.ac.uk/ena/data/view/U30693
EMBL	U30694	http://www.ebi.ac.uk/ena/data/view/U30694
EMBL	U30695	http://www.ebi.ac.uk/ena/data/view/U30695
EMBL	U30696	http://www.ebi.ac.uk/ena/data/view/U30696
EMBL	U30697	http://www.ebi.ac.uk/ena/data/view/U30697
EMBL	U30698	http://www.ebi.ac.uk/ena/data/view/U30698
EMBL	U30699	http://www.ebi.ac.uk/ena/data/view/U30699
EMBL	U30700	http://www.ebi.ac.uk/ena/data/view/U30700
EMBL	U30701	http://www.ebi.ac.uk/ena/data/view/U30701
EMBL	U30702	http://www.ebi.ac.uk/ena/data/view/U30702
EMBL	U30703	http://www.ebi.ac.uk/ena/data/view/U30703
EMBL	U30704	http://www.ebi.ac.uk/ena/data/view/U30704
EMBL	U30705	http://www.ebi.ac.uk/ena/data/view/U30705
EMBL	U30706	http://www.ebi.ac.uk/ena/data/view/U30706
EMBL	U30707	http://www.ebi.ac.uk/ena/data/view/U30707
EMBL	Z50091	http://www.ebi.ac.uk/ena/data/view/Z50091
EMBL	Z50092	http://www.ebi.ac.uk/ena/data/view/Z50092
EMBL	Z50093	http://www.ebi.ac.uk/ena/data/view/Z50093
Ensembl	ENST00000362061	http://www.ensembl.org/id/ENST00000362061
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005891
GO_component	GO:0030315	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030315
GO_component	GO:0031674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031674
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0008331	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008331
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0006936	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006936
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:0086010	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086010
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.20.120.350	http://www.cathdb.info/version/latest/superfamily/1.20.120.350
GeneCards	CACNA1S	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CACNA1S
GeneID	779	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=779
GeneTree	ENSGT00830000128247	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00830000128247
H-InvDB	HIX0028855	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0028855
HGNC	HGNC:1397	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1397
HOGENOM	HOG000231529	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231529&db=HOGENOM6
HOVERGEN	HBG050763	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050763&db=HOVERGEN
HPA	CAB009507	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB009507
HPA	HPA048892	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA048892
HPA	HPA056815	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA056815
InParanoid	Q13698	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q13698
IntAct	Q13698	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q13698*
InterPro	IPR002077	http://www.ebi.ac.uk/interpro/entry/IPR002077
InterPro	IPR005446	http://www.ebi.ac.uk/interpro/entry/IPR005446
InterPro	IPR005450	http://www.ebi.ac.uk/interpro/entry/IPR005450
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR014873	http://www.ebi.ac.uk/interpro/entry/IPR014873
InterPro	IPR027359	http://www.ebi.ac.uk/interpro/entry/IPR027359
InterPro	IPR031649	http://www.ebi.ac.uk/interpro/entry/IPR031649
Jabion	779	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=779
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00215	http://www.genome.jp/dbget-bin/www_bget?H00215
KEGG_Disease	H00746	http://www.genome.jp/dbget-bin/www_bget?H00746
KEGG_Gene	hsa:779	http://www.genome.jp/dbget-bin/www_bget?hsa:779
KEGG_Orthology	KO:K04857	http://www.genome.jp/dbget-bin/www_bget?KO:K04857
KEGG_Pathway	ko04010	http://www.genome.jp/kegg-bin/show_pathway?ko04010
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko04270	http://www.genome.jp/kegg-bin/show_pathway?ko04270
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04725	http://www.genome.jp/kegg-bin/show_pathway?ko04725
KEGG_Pathway	ko04726	http://www.genome.jp/kegg-bin/show_pathway?ko04726
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
KEGG_Pathway	ko04912	http://www.genome.jp/kegg-bin/show_pathway?ko04912
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05410	http://www.genome.jp/kegg-bin/show_pathway?ko05410
KEGG_Pathway	ko05412	http://www.genome.jp/kegg-bin/show_pathway?ko05412
KEGG_Pathway	ko05414	http://www.genome.jp/kegg-bin/show_pathway?ko05414
MIM	114208	http://www.ncbi.nlm.nih.gov/omim/114208
MIM	170400	http://www.ncbi.nlm.nih.gov/omim/170400
MIM	188580	http://www.ncbi.nlm.nih.gov/omim/188580
MIM	601887	http://www.ncbi.nlm.nih.gov/omim/601887
MINT	MINT-7899448	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-7899448
OMA	DFAYYYF	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DFAYYYF
Orphanet	397755	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=397755
Orphanet	423	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=423
Orphanet	681	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=681
Orphanet	79102	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=79102
OrthoDB	EOG091G0TKO	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0TKO
PANTHER	PTHR10037:SF190	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10037:SF190
PDB	2VAY	http://www.ebi.ac.uk/pdbe-srv/view/entry/2VAY
PDBsum	2VAY	http://www.ebi.ac.uk/pdbsum/2VAY
PRINTS	PR00167	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00167
PRINTS	PR01630	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01630
PRINTS	PR01634	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01634
PSORT	swissprot:CAC1S_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CAC1S_HUMAN
PSORT-B	swissprot:CAC1S_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CAC1S_HUMAN
PSORT2	swissprot:CAC1S_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CAC1S_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF08763	http://pfam.xfam.org/family/PF08763
Pfam	PF16905	http://pfam.xfam.org/family/PF16905
PharmGKB	PA85	http://www.pharmgkb.org/do/serve?objId=PA85&objCls=Gene
Phobius	swissprot:CAC1S_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CAC1S_HUMAN
PhylomeDB	Q13698	http://phylomedb.org/?seqid=Q13698
ProteinModelPortal	Q13698	http://www.proteinmodelportal.org/query/uniprot/Q13698
PubMed	15001631	http://www.ncbi.nlm.nih.gov/pubmed/15001631
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17418573	http://www.ncbi.nlm.nih.gov/pubmed/17418573
PubMed	18162704	http://www.ncbi.nlm.nih.gov/pubmed/18162704
PubMed	19118277	http://www.ncbi.nlm.nih.gov/pubmed/19118277
PubMed	7713519	http://www.ncbi.nlm.nih.gov/pubmed/7713519
PubMed	7916735	http://www.ncbi.nlm.nih.gov/pubmed/7916735
PubMed	7987325	http://www.ncbi.nlm.nih.gov/pubmed/7987325
PubMed	8004673	http://www.ncbi.nlm.nih.gov/pubmed/8004673
PubMed	8838325	http://www.ncbi.nlm.nih.gov/pubmed/8838325
PubMed	9199552	http://www.ncbi.nlm.nih.gov/pubmed/9199552
Reactome	R-HSA-419037	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-419037
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
Reactome	R-HSA-5576893	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576893
Reactome	R-HSA-5576894	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576894
RefSeq	NP_000060	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000060
SMART	SM01062	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01062
SMR	Q13698	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q13698
STRING	9606.ENSP00000355192	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000355192&targetmode=cogs
UCSC	uc001gvv	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001gvv&org=rat
UniGene	Hs.1294	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.1294
UniProtKB	CAC1S_HUMAN	http://www.uniprot.org/uniprot/CAC1S_HUMAN
UniProtKB-AC	Q13698	http://www.uniprot.org/uniprot/Q13698
charge	swissprot:CAC1S_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CAC1S_HUMAN
eggNOG	ENOG410XNP6	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNP6
eggNOG	KOG2301	http://eggnogapi.embl.de/nog_data/html/tree/KOG2301
epestfind	swissprot:CAC1S_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CAC1S_HUMAN
garnier	swissprot:CAC1S_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CAC1S_HUMAN
helixturnhelix	swissprot:CAC1S_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CAC1S_HUMAN
hmoment	swissprot:CAC1S_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CAC1S_HUMAN
iep	swissprot:CAC1S_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CAC1S_HUMAN
inforesidue	swissprot:CAC1S_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CAC1S_HUMAN
neXtProt	NX_Q13698	http://www.nextprot.org/db/entry/NX_Q13698
octanol	swissprot:CAC1S_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CAC1S_HUMAN
pepcoil	swissprot:CAC1S_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CAC1S_HUMAN
pepdigest	swissprot:CAC1S_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CAC1S_HUMAN
pepinfo	swissprot:CAC1S_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CAC1S_HUMAN
pepnet	swissprot:CAC1S_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CAC1S_HUMAN
pepstats	swissprot:CAC1S_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CAC1S_HUMAN
pepwheel	swissprot:CAC1S_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CAC1S_HUMAN
pepwindow	swissprot:CAC1S_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CAC1S_HUMAN
sigcleave	swissprot:CAC1S_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CAC1S_HUMAN
## Database	ID	URL or Descriptions
# BioGrid	119795	5
# Ensembl	ENST00000270310	ENSP00000270310; ENSG00000221946
# ExpressionAtlas	P58549	baseline and differential
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005216	ion channel activity; IEA:InterPro.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0043269	regulation of ion transport; IEA:Ensembl.
# GO_process	GO:1903779	regulation of cardiac conduction; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P58549	HS
# HGNC	HGNC:4034	FXYD7
# INTERACTION	FXYD7_HUMAN	Q92624 APPBP2; NbExp=5; IntAct=EBI-10216171, EBI-743771; O43765 SGTA; NbExp=7; IntAct=EBI-10216171, EBI-347996; 
# IntAct	P58549	2
# InterPro	IPR000272	Ion-transport_regulator_FXYD
# KEGG_Brite	ko02000	Transporters
# MIM	606684	gene
# Organism	FXYD7_HUMAN	Homo sapiens (Human)
# PROSITE	PS01310	FXYD
# Pfam	PF02038	ATP1G1_PLM_MAT8
# ProDom	PD005989	PD005989
# Proteomes	UP000005640	Chromosome 19
# Reactome	R-HSA-5578775	Ion homeostasis
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	FXYD7_HUMAN	FXYD domain-containing ion transport regulator 7
# RefSeq	NP_071289	NM_022006.1
# SIMILARITY	Belongs to the FXYD family. {ECO	0000305}.
# SUBCELLULAR LOCATION	FXYD7_HUMAN	Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. 
# UCSC	uc002nye	human
# eggNOG	ENOG410J7S9	Eukaryota
# eggNOG	ENOG4111ECY	LUCA
BLAST	swissprot:FXYD7_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:FXYD7_HUMAN
BioCyc	ZFISH:G66-33204-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33204-MONOMER
COXPRESdb	53822	http://coxpresdb.jp/data/gene/53822.shtml
CleanEx	HS_FXYD7	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_FXYD7
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	BC018619	http://www.ebi.ac.uk/ena/data/view/BC018619
Ensembl	ENST00000270310	http://www.ensembl.org/id/ENST00000270310
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005216	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005216
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0043269	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043269
GO_process	GO:1903779	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903779
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	FXYD7	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=FXYD7
GeneID	53822	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=53822
GeneTree	ENSGT00530000064670	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000064670
HGNC	HGNC:4034	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4034
HOGENOM	HOG000112680	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000112680&db=HOGENOM6
HOVERGEN	HBG051679	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051679&db=HOVERGEN
HPA	HPA026916	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA026916
InParanoid	P58549	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P58549
IntAct	P58549	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P58549*
InterPro	IPR000272	http://www.ebi.ac.uk/interpro/entry/IPR000272
Jabion	53822	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=53822
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:53822	http://www.genome.jp/dbget-bin/www_bget?hsa:53822
KEGG_Orthology	KO:K13364	http://www.genome.jp/dbget-bin/www_bget?KO:K13364
MIM	606684	http://www.ncbi.nlm.nih.gov/omim/606684
PROSITE	PS01310	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01310
PSORT	swissprot:FXYD7_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:FXYD7_HUMAN
PSORT-B	swissprot:FXYD7_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:FXYD7_HUMAN
PSORT2	swissprot:FXYD7_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:FXYD7_HUMAN
Pfam	PF02038	http://pfam.xfam.org/family/PF02038
PharmGKB	PA28450	http://www.pharmgkb.org/do/serve?objId=PA28450&objCls=Gene
Phobius	swissprot:FXYD7_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:FXYD7_HUMAN
PhylomeDB	P58549	http://phylomedb.org/?seqid=P58549
ProteinModelPortal	P58549	http://www.proteinmodelportal.org/query/uniprot/P58549
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-5578775	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5578775
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_071289	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_071289
SMR	P58549	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P58549
STRING	9606.ENSP00000270310	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000270310&targetmode=cogs
UCSC	uc002nye	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002nye&org=rat
UniGene	Hs.134729	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.134729
UniProtKB	FXYD7_HUMAN	http://www.uniprot.org/uniprot/FXYD7_HUMAN
UniProtKB-AC	P58549	http://www.uniprot.org/uniprot/P58549
charge	swissprot:FXYD7_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:FXYD7_HUMAN
eggNOG	ENOG410J7S9	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410J7S9
eggNOG	ENOG4111ECY	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111ECY
epestfind	swissprot:FXYD7_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:FXYD7_HUMAN
garnier	swissprot:FXYD7_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:FXYD7_HUMAN
helixturnhelix	swissprot:FXYD7_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:FXYD7_HUMAN
hmoment	swissprot:FXYD7_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:FXYD7_HUMAN
iep	swissprot:FXYD7_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:FXYD7_HUMAN
inforesidue	swissprot:FXYD7_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:FXYD7_HUMAN
neXtProt	NX_P58549	http://www.nextprot.org/db/entry/NX_P58549
octanol	swissprot:FXYD7_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:FXYD7_HUMAN
pepcoil	swissprot:FXYD7_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:FXYD7_HUMAN
pepdigest	swissprot:FXYD7_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:FXYD7_HUMAN
pepinfo	swissprot:FXYD7_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:FXYD7_HUMAN
pepnet	swissprot:FXYD7_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:FXYD7_HUMAN
pepstats	swissprot:FXYD7_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:FXYD7_HUMAN
pepwheel	swissprot:FXYD7_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:FXYD7_HUMAN
pepwindow	swissprot:FXYD7_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:FXYD7_HUMAN
sigcleave	swissprot:FXYD7_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:FXYD7_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	VATE1_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P36543-1; Sequence=Displayed; Name=2; IsoId=P36543-2; Sequence=VSP_042925; Note=No experimental confirmation available.; Name=3; IsoId=P36543-3; Sequence=VSP_044589; 
# AltName	VATE1_HUMAN	V-ATPase 31 kDa subunit
# AltName	VATE1_HUMAN	Vacuolar proton pump subunit E 1
# BioGrid	107012	60
# CCDS	CCDS13745	-. [P36543-1]
# CCDS	CCDS42977	-. [P36543-2]
# CCDS	CCDS42978	-. [P36543-3]
# ChiTaRS	ATP6V1E1	human
# Ensembl	ENST00000253413	ENSP00000253413; ENSG00000131100. [P36543-1]
# Ensembl	ENST00000399796	ENSP00000382694; ENSG00000131100. [P36543-3]
# Ensembl	ENST00000399798	ENSP00000382696; ENSG00000131100. [P36543-2]
# ExpressionAtlas	P36543	baseline and differential
# FUNCTION	VATE1_HUMAN	Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. 
# GO_component	GO:0005739	mitochondrion; IEA:Ensembl.
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005768	endosome; ISS:UniProtKB.
# GO_component	GO:0005829	cytosol; ISS:UniProtKB.
# GO_component	GO:0005902	microvillus; IEA:Ensembl.
# GO_component	GO:0016324	apical plasma membrane; ISS:UniProtKB.
# GO_component	GO:0016469	proton-transporting two-sector ATPase complex; TAS:ProtInc.
# GO_component	GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain; IEA:InterPro.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism; IEA:Ensembl.
# GO_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
# GO_function	GO:0051117	ATPase binding; IPI:UniProtKB.
# GO_process	GO:0008286	insulin receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0015991	ATP hydrolysis coupled proton transport; IEA:Ensembl.
# GO_process	GO:0015992	proton transport; TAS:ProtInc.
# GO_process	GO:0016241	regulation of macroautophagy; NAS:ParkinsonsUK-UCL.
# GO_process	GO:0033572	transferrin transport; TAS:Reactome.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0090383	phagosome acidification; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P36543	HS
# HAMAP	MF_00311	ATP_synth_E_arch
# HGNC	HGNC:857	ATP6V1E1
# IntAct	P36543	12
# InterPro	IPR002842	ATPase_V1/A1-cplx_esu
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04966	Collecting duct acid secretion
# KEGG_Pathway	ko05110	Vibrio cholerae infection
# KEGG_Pathway	ko05120	Epithelial cell signaling in Helicobacter pylori infection
# KEGG_Pathway	ko05323	Rheumatoid arthritis
# MIM	108746	gene
# Organism	VATE1_HUMAN	Homo sapiens (Human)
# PIR	S60562	S60562
# Pfam	PF01991	vATP-synt_E
# Proteomes	UP000005640	Chromosome 22
# Reactome	R-HSA-1222556	ROS, RNS production in response to bacteria
# Reactome	R-HSA-77387	Insulin receptor recycling
# Reactome	R-HSA-917977	Transferrin endocytosis and recycling
# Reactome	R-HSA-983712	Ion channel transport
# RecName	VATE1_HUMAN	V-type proton ATPase subunit E 1
# RefSeq	NP_001034455	NM_001039366.1. [P36543-2]
# RefSeq	NP_001034456	NM_001039367.1. [P36543-3]
# RefSeq	NP_001687	NM_001696.3. [P36543-1]
# SIMILARITY	Belongs to the V-ATPase E subunit family. {ECO	0000305}.
# SUBUNIT	VATE1_HUMAN	V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components  a, c, c', c'' and d). Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2 (By similarity). Interacts with ALDOC. Interacts with RAB11B. {ECO 0000250, ECO 0000269|PubMed 11399750, ECO 0000269|PubMed 20717956}. 
# TCDB	3.A.2.2	the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily
# TISSUE SPECIFICITY	Ubiquitous. {ECO:0000269|PubMed	12036578}. 
# UCSC	uc002zms	human. [P36543-1]
# eggNOG	COG1390	LUCA
# eggNOG	KOG1664	Eukaryota
BLAST	swissprot:VATE1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VATE1_HUMAN
BioCyc	MetaCyc:HS05489-MONOMER	http://biocyc.org/getid?id=MetaCyc:HS05489-MONOMER
BioCyc	ZFISH:HS05489-MONOMER	http://biocyc.org/getid?id=ZFISH:HS05489-MONOMER
COG	COG1390	http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1390
COXPRESdb	529	http://coxpresdb.jp/data/gene/529.shtml
CleanEx	HS_ATP6V1E1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP6V1E1
DOI	10.1002/jcp.22388	http://dx.doi.org/10.1002/jcp.22388
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1006/bbrc.1993.2434	http://dx.doi.org/10.1006/bbrc.1993.2434
DOI	10.1016/S0378-1119(02)00542-5	http://dx.doi.org/10.1016/S0378-1119(02)00542-5
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1038/990031	http://dx.doi.org/10.1038/990031
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M008768200	http://dx.doi.org/10.1074/jbc.M008768200
DOI	10.1093/hmg/3.2.335	http://dx.doi.org/10.1093/hmg/3.2.335
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DOI	10.1186/gb-2004-5-10-r84	http://dx.doi.org/10.1186/gb-2004-5-10-r84
EMBL	AC004019	http://www.ebi.ac.uk/ena/data/view/AC004019
EMBL	AC006285	http://www.ebi.ac.uk/ena/data/view/AC006285
EMBL	AC007666	http://www.ebi.ac.uk/ena/data/view/AC007666
EMBL	AK294623	http://www.ebi.ac.uk/ena/data/view/AK294623
EMBL	AK315941	http://www.ebi.ac.uk/ena/data/view/AK315941
EMBL	BC004443	http://www.ebi.ac.uk/ena/data/view/BC004443
EMBL	CR456385	http://www.ebi.ac.uk/ena/data/view/CR456385
EMBL	X71491	http://www.ebi.ac.uk/ena/data/view/X71491
EMBL	X76228	http://www.ebi.ac.uk/ena/data/view/X76228
Ensembl	ENST00000253413	http://www.ensembl.org/id/ENST00000253413
Ensembl	ENST00000399796	http://www.ensembl.org/id/ENST00000399796
Ensembl	ENST00000399798	http://www.ensembl.org/id/ENST00000399798
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005902	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005902
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0016469	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016469
GO_component	GO:0033178	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033178
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0008553	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008553
GO_function	GO:0046961	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046961
GO_function	GO:0051117	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051117
GO_process	GO:0008286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008286
GO_process	GO:0015991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015991
GO_process	GO:0015992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992
GO_process	GO:0016241	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016241
GO_process	GO:0033572	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033572
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0090383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090383
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ATP6V1E1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP6V1E1
GeneID	529	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=529
GeneTree	ENSGT00390000002730	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000002730
HAMAP	MF_00311	http://hamap.expasy.org/unirule/MF_00311
HGNC	HGNC:857	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:857
HOGENOM	HOG000202506	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202506&db=HOGENOM6
HOVERGEN	HBG002309	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG002309&db=HOVERGEN
HPA	CAB009528	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB009528
HPA	CAB018699	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB018699
HPA	HPA029196	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA029196
InParanoid	P36543	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36543
IntAct	P36543	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36543*
InterPro	IPR002842	http://www.ebi.ac.uk/interpro/entry/IPR002842
Jabion	529	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=529
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:529	http://www.genome.jp/dbget-bin/www_bget?hsa:529
KEGG_Orthology	KO:K02150	http://www.genome.jp/dbget-bin/www_bget?KO:K02150
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04966	http://www.genome.jp/kegg-bin/show_pathway?ko04966
KEGG_Pathway	ko05110	http://www.genome.jp/kegg-bin/show_pathway?ko05110
KEGG_Pathway	ko05120	http://www.genome.jp/kegg-bin/show_pathway?ko05120
KEGG_Pathway	ko05323	http://www.genome.jp/kegg-bin/show_pathway?ko05323
MIM	108746	http://www.ncbi.nlm.nih.gov/omim/108746
MINT	MINT-5002575	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5002575
OMA	EYQTVLT	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EYQTVLT
OrthoDB	EOG091G0OGO	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0OGO
PSORT	swissprot:VATE1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VATE1_HUMAN
PSORT-B	swissprot:VATE1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VATE1_HUMAN
PSORT2	swissprot:VATE1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VATE1_HUMAN
Pfam	PF01991	http://pfam.xfam.org/family/PF01991
PharmGKB	PA25158	http://www.pharmgkb.org/do/serve?objId=PA25158&objCls=Gene
Phobius	swissprot:VATE1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VATE1_HUMAN
PhylomeDB	P36543	http://phylomedb.org/?seqid=P36543
ProteinModelPortal	P36543	http://www.proteinmodelportal.org/query/uniprot/P36543
PubMed	10591208	http://www.ncbi.nlm.nih.gov/pubmed/10591208
PubMed	11399750	http://www.ncbi.nlm.nih.gov/pubmed/11399750
PubMed	12036578	http://www.ncbi.nlm.nih.gov/pubmed/12036578
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	1533641	http://www.ncbi.nlm.nih.gov/pubmed/1533641
PubMed	15461802	http://www.ncbi.nlm.nih.gov/pubmed/15461802
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	20717956	http://www.ncbi.nlm.nih.gov/pubmed/20717956
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	8004105	http://www.ncbi.nlm.nih.gov/pubmed/8004105
PubMed	8250920	http://www.ncbi.nlm.nih.gov/pubmed/8250920
Reactome	R-HSA-1222556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1222556
Reactome	R-HSA-77387	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-77387
Reactome	R-HSA-917977	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917977
Reactome	R-HSA-983712	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983712
RefSeq	NP_001034455	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001034455
RefSeq	NP_001034456	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001034456
RefSeq	NP_001687	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001687
SMR	P36543	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P36543
STRING	9606.ENSP00000253413	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000253413&targetmode=cogs
STRING	COG1390	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1390&targetmode=cogs
TCDB	3.A.2.2	http://www.tcdb.org/search/result.php?tc=3.A.2.2
UCSC	uc002zms	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002zms&org=rat
UniGene	Hs.517338	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.517338
UniProtKB	VATE1_HUMAN	http://www.uniprot.org/uniprot/VATE1_HUMAN
UniProtKB-AC	P36543	http://www.uniprot.org/uniprot/P36543
charge	swissprot:VATE1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VATE1_HUMAN
eggNOG	COG1390	http://eggnogapi.embl.de/nog_data/html/tree/COG1390
eggNOG	KOG1664	http://eggnogapi.embl.de/nog_data/html/tree/KOG1664
epestfind	swissprot:VATE1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VATE1_HUMAN
garnier	swissprot:VATE1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VATE1_HUMAN
helixturnhelix	swissprot:VATE1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VATE1_HUMAN
hmoment	swissprot:VATE1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VATE1_HUMAN
iep	swissprot:VATE1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VATE1_HUMAN
inforesidue	swissprot:VATE1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VATE1_HUMAN
neXtProt	NX_P36543	http://www.nextprot.org/db/entry/NX_P36543
octanol	swissprot:VATE1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VATE1_HUMAN
pepcoil	swissprot:VATE1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VATE1_HUMAN
pepdigest	swissprot:VATE1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VATE1_HUMAN
pepinfo	swissprot:VATE1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VATE1_HUMAN
pepnet	swissprot:VATE1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VATE1_HUMAN
pepstats	swissprot:VATE1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VATE1_HUMAN
pepwheel	swissprot:VATE1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VATE1_HUMAN
pepwindow	swissprot:VATE1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VATE1_HUMAN
sigcleave	swissprot:VATE1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VATE1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S22AN_HUMAN	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=A1A5C7-1; Sequence=Displayed; Name=2; IsoId=A1A5C7-2; Sequence=VSP_028954; Name=3; IsoId=A1A5C7-3; Sequence=VSP_028955; Note=No experimental confirmation available.; Name=4; IsoId=A1A5C7-4; Sequence=VSP_028956; Note=No experimental confirmation available.; 
# BioGrid	121960	14
# CCDS	CCDS34331	-. [A1A5C7-2]
# CCDS	CCDS47363	-. [A1A5C7-1]
# CCDS	CCDS75389	-. [A1A5C7-4]
# CDD	cd06174	MFS
# ChiTaRS	SLC22A23	human
# Ensembl	ENST00000380298	ENSP00000369653; ENSG00000137266. [A1A5C7-4]
# Ensembl	ENST00000380302	ENSP00000369657; ENSG00000137266. [A1A5C7-2]
# Ensembl	ENST00000406686	ENSP00000385028; ENSG00000137266. [A1A5C7-1]
# Ensembl	ENST00000490273	ENSP00000419463; ENSG00000137266. [A1A5C7-2]
# ExpressionAtlas	A1A5C7	baseline and differential
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_function	GO:0008514	organic anion transmembrane transporter activity; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# Genevisible	A1A5C7	HS
# HGNC	HGNC:21106	SLC22A23
# INTERACTION	S22AN_HUMAN	P60410 KRTAP10-8; NbExp=3; IntAct=EBI-10171756, EBI-10171774; P26371 KRTAP5-9; NbExp=3; IntAct=EBI-10171756, EBI-3958099; Q7Z3S9 NOTCH2NL; NbExp=3; IntAct=EBI-10171756, EBI-945833; 
# IntAct	A1A5C7	4
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR005829	Sugar_transporter_CS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	611697	gene
# Organism	S22AN_HUMAN	Homo sapiens (Human)
# PROSITE	PS00216	SUGAR_TRANSPORT_1
# PROSITE	PS50850	MFS
# Pfam	PF00083	Sugar_tr
# Proteomes	UP000005640	Chromosome 6
# RecName	S22AN_HUMAN	Solute carrier family 22 member 23
# RefSeq	NP_001273384	NM_001286455.1. [A1A5C7-2]
# RefSeq	NP_001273385	NM_001286456.1. [A1A5C7-4]
# RefSeq	NP_056297	NM_015482.1. [A1A5C7-1]
# RefSeq	NP_068764	NM_021945.6. [A1A5C7-2]
# RefSeq	XP_016866670	XM_017011181.1. [A1A5C7-2]
# RefSeq	XP_016866675	XM_017011186.1. [A1A5C7-2]
# SEQUENCE CAUTION	Sequence=BAD18753.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI12303.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305}; Sequence=CAI40959.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
# SIMILARITY	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S22AN_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.19.28	the major facilitator superfamily (mfs)
# UCSC	uc003mvm	human. [A1A5C7-1]
# eggNOG	ENOG410ZZ6M	LUCA
# eggNOG	KOG0255	Eukaryota
BLAST	swissprot:S22AN_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S22AN_HUMAN
COXPRESdb	63027	http://coxpresdb.jp/data/gene/63027.shtml
CleanEx	HS_SLC22A23	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC22A23
DOI	10.1016/j.ygeno.2007.03.017	http://dx.doi.org/10.1016/j.ygeno.2007.03.017
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AK172770	http://www.ebi.ac.uk/ena/data/view/AK172770
EMBL	AL160398	http://www.ebi.ac.uk/ena/data/view/AL160398
EMBL	AL160398	http://www.ebi.ac.uk/ena/data/view/AL160398
EMBL	AL445309	http://www.ebi.ac.uk/ena/data/view/AL445309
EMBL	AL445309	http://www.ebi.ac.uk/ena/data/view/AL445309
EMBL	BC040876	http://www.ebi.ac.uk/ena/data/view/BC040876
EMBL	BC128580	http://www.ebi.ac.uk/ena/data/view/BC128580
EMBL	BC128581	http://www.ebi.ac.uk/ena/data/view/BC128581
Ensembl	ENST00000380298	http://www.ensembl.org/id/ENST00000380298
Ensembl	ENST00000380302	http://www.ensembl.org/id/ENST00000380302
Ensembl	ENST00000406686	http://www.ensembl.org/id/ENST00000406686
Ensembl	ENST00000490273	http://www.ensembl.org/id/ENST00000490273
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_function	GO:0008514	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008514
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GeneCards	SLC22A23	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC22A23
GeneID	63027	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=63027
GeneTree	ENSGT00390000014377	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000014377
H-InvDB	HIX0005541	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0005541
H-InvDB	HIX0005544	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0005544
HGNC	HGNC:21106	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:21106
HOGENOM	HOG000124569	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124569&db=HOGENOM6
HOVERGEN	HBG108437	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108437&db=HOVERGEN
HPA	HPA014697	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA014697
InParanoid	A1A5C7	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=A1A5C7
IntAct	A1A5C7	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=A1A5C7*
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR005829	http://www.ebi.ac.uk/interpro/entry/IPR005829
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	63027	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=63027
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:63027	http://www.genome.jp/dbget-bin/www_bget?hsa:63027
KEGG_Orthology	KO:K08215	http://www.genome.jp/dbget-bin/www_bget?KO:K08215
MIM	611697	http://www.ncbi.nlm.nih.gov/omim/611697
PROSITE	PS00216	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00216
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:S22AN_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S22AN_HUMAN
PSORT-B	swissprot:S22AN_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S22AN_HUMAN
PSORT2	swissprot:S22AN_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S22AN_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
PharmGKB	PA162403516	http://www.pharmgkb.org/do/serve?objId=PA162403516&objCls=Gene
Phobius	swissprot:S22AN_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S22AN_HUMAN
PhylomeDB	A1A5C7	http://phylomedb.org/?seqid=A1A5C7
ProteinModelPortal	A1A5C7	http://www.proteinmodelportal.org/query/uniprot/A1A5C7
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17714910	http://www.ncbi.nlm.nih.gov/pubmed/17714910
RefSeq	NP_001273384	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273384
RefSeq	NP_001273385	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273385
RefSeq	NP_056297	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_056297
RefSeq	NP_068764	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_068764
RefSeq	XP_016866670	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016866670
RefSeq	XP_016866675	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016866675
STRING	9606.ENSP00000385028	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000385028&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.19.28	http://www.tcdb.org/search/result.php?tc=2.A.1.19.28
UCSC	uc003mvm	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003mvm&org=rat
UniGene	Hs.713588	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.713588
UniProtKB	S22AN_HUMAN	http://www.uniprot.org/uniprot/S22AN_HUMAN
UniProtKB-AC	A1A5C7	http://www.uniprot.org/uniprot/A1A5C7
charge	swissprot:S22AN_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S22AN_HUMAN
eggNOG	ENOG410ZZ6M	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZZ6M
eggNOG	KOG0255	http://eggnogapi.embl.de/nog_data/html/tree/KOG0255
epestfind	swissprot:S22AN_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S22AN_HUMAN
garnier	swissprot:S22AN_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S22AN_HUMAN
helixturnhelix	swissprot:S22AN_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S22AN_HUMAN
hmoment	swissprot:S22AN_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S22AN_HUMAN
iep	swissprot:S22AN_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S22AN_HUMAN
inforesidue	swissprot:S22AN_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S22AN_HUMAN
neXtProt	NX_A1A5C7	http://www.nextprot.org/db/entry/NX_A1A5C7
octanol	swissprot:S22AN_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S22AN_HUMAN
pepcoil	swissprot:S22AN_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S22AN_HUMAN
pepdigest	swissprot:S22AN_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S22AN_HUMAN
pepinfo	swissprot:S22AN_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S22AN_HUMAN
pepnet	swissprot:S22AN_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S22AN_HUMAN
pepstats	swissprot:S22AN_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S22AN_HUMAN
pepwheel	swissprot:S22AN_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S22AN_HUMAN
pepwindow	swissprot:S22AN_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S22AN_HUMAN
sigcleave	swissprot:S22AN_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S22AN_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	NOX1_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=NOH-1L; IsoId=Q9Y5S8-1; Sequence=Displayed; Name=NOH-1S; IsoId=Q9Y5S8-2; Sequence=VSP_001577, VSP_001578; Name=NOH-1LV; IsoId=Q9Y5S8-3; Sequence=VSP_001579; 
# AltName	NOX1_HUMAN	Mitogenic oxidase 1
# AltName	NOX1_HUMAN	NADH/NADPH mitogenic oxidase subunit P65-MOX
# AltName	NOX1_HUMAN	NOH-1
# BioGrid	117966	3
# CCDS	CCDS14474	-. [Q9Y5S8-1]
# CCDS	CCDS14475	-. [Q9Y5S8-3]
# COFACTOR	Name=FAD; Xref=ChEBI:CHEBI	57692; Evidence={ECO:0000305}; 
# COFACTOR	Name=NADP(+); Xref=ChEBI:CHEBI	58349; Evidence={ECO:0000305}; 
# ChiTaRS	NOX1	human
# DISEASE	NOX1_HUMAN	Note=Defects in NOX1 may play a role in the pathogenesis of very early onset inflammatory bowel disease (VEOIBD), a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology diagnosed before 6 years of age. VEOIBD is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but the phenotype of children with onset of Crohn disease occurring younger than the age of 10 is predominantly colonic, with a lower risk of ileal disease. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO 0000269|PubMed 26301257}. 
# ENZYME REGULATION	NOX1_HUMAN	The oxidase activity is potentiated by NOXA1 and NOXO1. {ECO 0000269|PubMed 14617635, ECO 0000269|PubMed 16329988}. 
# Ensembl	ENST00000217885	ENSP00000217885; ENSG00000007952. [Q9Y5S8-3]
# Ensembl	ENST00000372966	ENSP00000362057; ENSG00000007952. [Q9Y5S8-1]
# ExpressionAtlas	Q9Y5S8	baseline and differential
# FUNCTION	NOX1_HUMAN	NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain. 
# GO_component	GO:0005769	early endosome; IDA:BHF-UCL.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IC:BHF-UCL.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0043020	NADPH oxidase complex; IDA:BHF-UCL.
# GO_component	GO:0071438	invadopodium membrane; IDA:UniProtKB.
# GO_function	GO:0016175	superoxide-generating NADPH oxidase activity; TAS:UniProtKB.
# GO_function	GO:0030171	voltage-gated proton channel activity; IDA:BHF-UCL.
# GO_function	GO:0046872	metal ion binding; IEA:UniProtKB-KW.
# GO_function	GO:0048365	Rac GTPase binding; IPI:BHF-UCL.
# GO_function	GO:0050661	NADP binding; IC:BHF-UCL.
# GO_process	GO:0001525	angiogenesis; IMP:BHF-UCL.
# GO_process	GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin; IEA:Ensembl.
# GO_process	GO:0006739	NADP metabolic process; IC:BHF-UCL.
# GO_process	GO:0006801	superoxide metabolic process; IMP:BHF-UCL.
# GO_process	GO:0006954	inflammatory response; TAS:BHF-UCL.
# GO_process	GO:0007165	signal transduction; TAS:BHF-UCL.
# GO_process	GO:0008217	regulation of blood pressure; TAS:BHF-UCL.
# GO_process	GO:0008284	positive regulation of cell proliferation; IDA:BHF-UCL.
# GO_process	GO:0010575	positive regulation of vascular endothelial growth factor production; IEP:BHF-UCL.
# GO_process	GO:0015992	proton transport; IDA:BHF-UCL.
# GO_process	GO:0016477	cell migration; IMP:BHF-UCL.
# GO_process	GO:0030198	extracellular matrix organization; IEA:Ensembl.
# GO_process	GO:0042554	superoxide anion generation; IDA:BHF-UCL.
# GO_process	GO:0042743	hydrogen peroxide metabolic process; IDA:BHF-UCL.
# GO_process	GO:0045726	positive regulation of integrin biosynthetic process; IMP:BHF-UCL.
# GO_process	GO:0045730	respiratory burst; TAS:BHF-UCL.
# GO_process	GO:0046330	positive regulation of JNK cascade; IEA:Ensembl.
# GO_process	GO:0048661	positive regulation of smooth muscle cell proliferation; ISS:BHF-UCL.
# GO_process	GO:0051454	intracellular pH elevation; IDA:BHF-UCL.
# GO_process	GO:0055114	oxidation-reduction process; IDA:BHF-UCL.
# GO_process	GO:0071455	cellular response to hyperoxia; IEA:Ensembl.
# GO_process	GO:0072592	oxygen metabolic process; IEA:Ensembl.
# GO_process	GO:1902177	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; IEA:Ensembl.
# GO_process	GO:1990451	cellular stress response to acidic pH; IDA:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005768	endosome
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016491	oxidoreductase activity
# GOslim_function	GO:0019899	enzyme binding
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0030198	extracellular matrix organization
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0048646	anatomical structure formation involved in morphogenesis
# GOslim_process	GO:0048870	cell motility
# GOslim_process	GO:0051186	cofactor metabolic process
# Genevisible	Q9Y5S8	HS
# HGNC	HGNC:7889	NOX1
# InterPro	IPR000778	Cyt_b245_heavy_chain
# InterPro	IPR013112	FAD-bd_8
# InterPro	IPR013121	Fe_red_NAD-bd_6
# InterPro	IPR013130	Fe3_Rdtase_TM_dom
# InterPro	IPR017927	Fd_Rdtase_FAD-bd
# InterPro	IPR017938	Riboflavin_synthase-like_b-brl
# InterPro	IPR029650	NOX1
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Pathway	ko04066	HIF-1 signaling pathway
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko04380	Osteoclast differentiation
# KEGG_Pathway	ko04670	Leukocyte transendothelial migration
# MIM	300225	gene
# Organism	NOX1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11972:SF71	PTHR11972:SF71; 2
# PRINTS	PR00466	GP91PHOX
# PROSITE	PS51384	FAD_FR
# PeroxiBase	5410	HsNOx01
# Pfam	PF01794	Ferric_reduct
# Pfam	PF08022	FAD_binding_8
# Pfam	PF08030	NAD_binding_6
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-5668599	RHO GTPases Activate NADPH Oxidases
# RecName	NOX1_HUMAN	NADPH oxidase 1
# RefSeq	NP_001258744	NM_001271815.1
# RefSeq	NP_008983	NM_007052.4. [Q9Y5S8-1]
# RefSeq	NP_039249	NM_013955.2. [Q9Y5S8-3]
# SIMILARITY	Contains 1 FAD-binding FR-type domain. {ECO:0000255|PROSITE-ProRule	PRU00716}. 
# SIMILARITY	Contains 1 ferric oxidoreductase domain. {ECO	0000305}.
# SUBCELLULAR LOCATION	NOX1_HUMAN	Cell projection, invadopodium membrane {ECO 0000269|PubMed 19755710}; Multi-pass membrane protein {ECO 0000269|PubMed 19755710}. Cell membrane {ECO 0000269|PubMed 26301257}. 
# SUBUNIT	NOX1_HUMAN	NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric complex supporting reactive oxygen species (ROS) production. Interacts with NOXA1 and NOXO1. {ECO 0000269|PubMed 16329988, ECO 0000269|PubMed 16636067}. 
# SUPFAM	SSF63380	SSF63380
# TCDB	5.B.1.1	the phagocyte (gp91(phox)) nadph oxidase family
# TISSUE SPECIFICITY	NOX1_HUMAN	NOH-1L is detected in colon, uterus, prostate, and colon carcinoma, but not in peripheral blood leukocytes. NOH- 1S is detected only in colon and colon carcinoma cells. 
# UCSC	uc004egj	human. [Q9Y5S8-1]
# eggNOG	ENOG410XNZY	LUCA
# eggNOG	KOG0039	Eukaryota
BLAST	swissprot:NOX1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NOX1_HUMAN
BioCyc	ZFISH:HS00225-MONOMER	http://biocyc.org/getid?id=ZFISH:HS00225-MONOMER
COXPRESdb	27035	http://coxpresdb.jp/data/gene/27035.shtml
CleanEx	HS_NOX1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_NOX1
DIP	DIP-60457N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-60457N
DOI	10.1016/j.bbrc.2005.11.108	http://dx.doi.org/10.1016/j.bbrc.2005.11.108
DOI	10.1016/j.bbrc.2013.12.086	http://dx.doi.org/10.1016/j.bbrc.2013.12.086
DOI	10.1016/j.jcmgh.2015.06.005	http://dx.doi.org/10.1016/j.jcmgh.2015.06.005
DOI	10.1038/43459	http://dx.doi.org/10.1038/43459
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M305968200	http://dx.doi.org/10.1074/jbc.M305968200
DOI	10.1074/jbc.M512751200	http://dx.doi.org/10.1074/jbc.M512751200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.287.5450.138	http://dx.doi.org/10.1126/science.287.5450.138
DOI	10.1126/scisignal.2000370	http://dx.doi.org/10.1126/scisignal.2000370
EC_number	EC:1.-.-.-	http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.-
EMBL	AF127763	http://www.ebi.ac.uk/ena/data/view/AF127763
EMBL	AF166326	http://www.ebi.ac.uk/ena/data/view/AF166326
EMBL	AF166327	http://www.ebi.ac.uk/ena/data/view/AF166327
EMBL	AF166328	http://www.ebi.ac.uk/ena/data/view/AF166328
EMBL	AK292201	http://www.ebi.ac.uk/ena/data/view/AK292201
EMBL	BC075014	http://www.ebi.ac.uk/ena/data/view/BC075014
EMBL	BC075015	http://www.ebi.ac.uk/ena/data/view/BC075015
EMBL	CH471115	http://www.ebi.ac.uk/ena/data/view/CH471115
EMBL	DQ314883	http://www.ebi.ac.uk/ena/data/view/DQ314883
EMBL	Z83819	http://www.ebi.ac.uk/ena/data/view/Z83819
EMBL	Z83819	http://www.ebi.ac.uk/ena/data/view/Z83819
ENZYME	1.-.-.-	http://enzyme.expasy.org/EC/1.-.-.-
Ensembl	ENST00000217885	http://www.ensembl.org/id/ENST00000217885
Ensembl	ENST00000372966	http://www.ensembl.org/id/ENST00000372966
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005769	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005769
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0043020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043020
GO_component	GO:0071438	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071438
GO_function	GO:0016175	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016175
GO_function	GO:0030171	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030171
GO_function	GO:0046872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_function	GO:0048365	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048365
GO_function	GO:0050661	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050661
GO_process	GO:0001525	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001525
GO_process	GO:0003081	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003081
GO_process	GO:0006739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006739
GO_process	GO:0006801	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006801
GO_process	GO:0006954	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006954
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0008217	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008217
GO_process	GO:0008284	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008284
GO_process	GO:0010575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010575
GO_process	GO:0015992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992
GO_process	GO:0016477	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016477
GO_process	GO:0030198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030198
GO_process	GO:0042554	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042554
GO_process	GO:0042743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042743
GO_process	GO:0045726	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045726
GO_process	GO:0045730	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045730
GO_process	GO:0046330	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046330
GO_process	GO:0048661	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048661
GO_process	GO:0051454	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051454
GO_process	GO:0055114	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114
GO_process	GO:0071455	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071455
GO_process	GO:0072592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072592
GO_process	GO:1902177	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902177
GO_process	GO:1990451	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990451
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005768	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005768
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016491	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491
GOslim_function	GO:0019899	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0030198	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030198
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0048646	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048646
GOslim_process	GO:0048870	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870
GOslim_process	GO:0051186	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186
GeneCards	NOX1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=NOX1
GeneID	27035	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27035
GeneTree	ENSGT00550000074350	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074350
HGNC	HGNC:7889	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:7889
HOGENOM	HOG000216669	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000216669&db=HOGENOM6
HOVERGEN	HBG003760	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003760&db=HOVERGEN
HPA	HPA035299	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035299
HPA	HPA035300	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035300
InParanoid	Q9Y5S8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y5S8
IntEnz	1	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1
InterPro	IPR000778	http://www.ebi.ac.uk/interpro/entry/IPR000778
InterPro	IPR013112	http://www.ebi.ac.uk/interpro/entry/IPR013112
InterPro	IPR013121	http://www.ebi.ac.uk/interpro/entry/IPR013121
InterPro	IPR013130	http://www.ebi.ac.uk/interpro/entry/IPR013130
InterPro	IPR017927	http://www.ebi.ac.uk/interpro/entry/IPR017927
InterPro	IPR017938	http://www.ebi.ac.uk/interpro/entry/IPR017938
InterPro	IPR029650	http://www.ebi.ac.uk/interpro/entry/IPR029650
Jabion	27035	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=27035
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Gene	hsa:27035	http://www.genome.jp/dbget-bin/www_bget?hsa:27035
KEGG_Orthology	KO:K08008	http://www.genome.jp/dbget-bin/www_bget?KO:K08008
KEGG_Pathway	ko04066	http://www.genome.jp/kegg-bin/show_pathway?ko04066
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko04380	http://www.genome.jp/kegg-bin/show_pathway?ko04380
KEGG_Pathway	ko04670	http://www.genome.jp/kegg-bin/show_pathway?ko04670
MIM	300225	http://www.ncbi.nlm.nih.gov/omim/300225
OMA	IATSHPK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IATSHPK
OrthoDB	EOG091G09RV	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G09RV
PANTHER	PTHR11972:SF71	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11972:SF71
PRINTS	PR00466	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00466
PROSITE	PS51384	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51384
PSORT	swissprot:NOX1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NOX1_HUMAN
PSORT-B	swissprot:NOX1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NOX1_HUMAN
PSORT2	swissprot:NOX1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NOX1_HUMAN
PeroxiBase	5410	http://peroxibase.toulouse.inra.fr/listing.php?action=view&id=5410
Pfam	PF01794	http://pfam.xfam.org/family/PF01794
Pfam	PF08022	http://pfam.xfam.org/family/PF08022
Pfam	PF08030	http://pfam.xfam.org/family/PF08030
PharmGKB	PA31690	http://www.pharmgkb.org/do/serve?objId=PA31690&objCls=Gene
Phobius	swissprot:NOX1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NOX1_HUMAN
PhylomeDB	Q9Y5S8	http://phylomedb.org/?seqid=Q9Y5S8
ProteinModelPortal	Q9Y5S8	http://www.proteinmodelportal.org/query/uniprot/Q9Y5S8
PubMed	10485709	http://www.ncbi.nlm.nih.gov/pubmed/10485709
PubMed	10615049	http://www.ncbi.nlm.nih.gov/pubmed/10615049
PubMed	14617635	http://www.ncbi.nlm.nih.gov/pubmed/14617635
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	16329988	http://www.ncbi.nlm.nih.gov/pubmed/16329988
PubMed	16636067	http://www.ncbi.nlm.nih.gov/pubmed/16636067
PubMed	19755710	http://www.ncbi.nlm.nih.gov/pubmed/19755710
PubMed	24365146	http://www.ncbi.nlm.nih.gov/pubmed/24365146
PubMed	26301257	http://www.ncbi.nlm.nih.gov/pubmed/26301257
Reactome	R-HSA-5668599	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5668599
RefSeq	NP_001258744	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001258744
RefSeq	NP_008983	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_008983
RefSeq	NP_039249	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_039249
STRING	9606.ENSP00000362057	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000362057&targetmode=cogs
SUPFAM	SSF63380	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63380
TCDB	5.B.1.1	http://www.tcdb.org/search/result.php?tc=5.B.1.1
UCSC	uc004egj	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004egj&org=rat
UniGene	Hs.592227	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.592227
UniProtKB	NOX1_HUMAN	http://www.uniprot.org/uniprot/NOX1_HUMAN
UniProtKB-AC	Q9Y5S8	http://www.uniprot.org/uniprot/Q9Y5S8
charge	swissprot:NOX1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NOX1_HUMAN
eggNOG	ENOG410XNZY	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNZY
eggNOG	KOG0039	http://eggnogapi.embl.de/nog_data/html/tree/KOG0039
epestfind	swissprot:NOX1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NOX1_HUMAN
garnier	swissprot:NOX1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NOX1_HUMAN
helixturnhelix	swissprot:NOX1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NOX1_HUMAN
hmoment	swissprot:NOX1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NOX1_HUMAN
iep	swissprot:NOX1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NOX1_HUMAN
inforesidue	swissprot:NOX1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NOX1_HUMAN
neXtProt	NX_Q9Y5S8	http://www.nextprot.org/db/entry/NX_Q9Y5S8
octanol	swissprot:NOX1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NOX1_HUMAN
pepcoil	swissprot:NOX1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NOX1_HUMAN
pepdigest	swissprot:NOX1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NOX1_HUMAN
pepinfo	swissprot:NOX1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NOX1_HUMAN
pepnet	swissprot:NOX1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NOX1_HUMAN
pepstats	swissprot:NOX1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NOX1_HUMAN
pepwheel	swissprot:NOX1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NOX1_HUMAN
pepwindow	swissprot:NOX1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NOX1_HUMAN
sigcleave	swissprot:NOX1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NOX1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S22AB_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NSA0-1; Sequence=Displayed; Name=2; IsoId=Q9NSA0-2; Sequence=VSP_018319; Note=No experimental confirmation available.; 
# AltName	S22AB_HUMAN	Organic anion transporter 4
# BioGrid	120967	3
# CCDS	CCDS76425	-. [Q9NSA0-2]
# CCDS	CCDS8074	-. [Q9NSA0-1]
# CDD	cd06174	MFS
# ChiTaRS	SLC22A11	human
# DrugBank	DB00168	Aspartame
# DrugBank	DB00175	Pravastatin
# DrugBank	DB00254	Doxycycline
# DrugBank	DB00286	Conjugated Estrogens
# DrugBank	DB00328	Indomethacin
# DrugBank	DB00345	Aminohippurate
# DrugBank	DB00456	Cefalotin
# DrugBank	DB00493	Cefotaxime
# DrugBank	DB00495	Zidovudine
# DrugBank	DB00501	Cimetidine
# DrugBank	DB00554	Piroxicam
# DrugBank	DB00563	Methotrexate
# DrugBank	DB00586	Diclofenac
# DrugBank	DB00595	Oxytetracycline
# DrugBank	DB00695	Furosemide
# DrugBank	DB00759	Tetracycline
# DrugBank	DB00783	Estradiol
# DrugBank	DB00812	Phenylbutazone
# DrugBank	DB00887	Bumetanide
# DrugBank	DB00917	Dinoprostone
# DrugBank	DB00936	Salicylic acid
# DrugBank	DB01009	Ketoprofen
# DrugBank	DB01017	Minocycline
# DrugBank	DB01032	Probenecid
# DrugBank	DB01050	Ibuprofen
# DrugBank	DB01051	Novobiocin
# DrugBank	DB01053	Benzylpenicillin
# DrugBank	DB01160	Dinoprost Tromethamine
# DrugBank	DB01212	Ceftriaxone
# DrugBank	DB01326	Cefamandole
# DrugBank	DB01327	Cefazolin
# DrugBank	DB01329	Cefoperazone
# Ensembl	ENST00000301891	ENSP00000301891; ENSG00000168065. [Q9NSA0-1]
# Ensembl	ENST00000377585	ENSP00000366809; ENSG00000168065. [Q9NSA0-2]
# ExpressionAtlas	Q9NSA0	baseline and differential
# FUNCTION	S22AB_HUMAN	Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds. {ECO 0000269|PubMed 10660625, ECO 0000269|PubMed 15102942, ECO 0000269|PubMed 15291761}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0009897	external side of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016324	apical plasma membrane; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0005452	inorganic anion exchanger activity; IDA:UniProtKB.
# GO_function	GO:0008514	organic anion transmembrane transporter activity; IDA:UniProtKB.
# GO_function	GO:0015347	sodium-independent organic anion transmembrane transporter activity; IDA:UniProtKB.
# GO_process	GO:0015711	organic anion transport; IDA:UniProtKB.
# GO_process	GO:0043252	sodium-independent organic anion transport; IBA:GO_Central.
# GO_process	GO:0046415	urate metabolic process; IMP:BHF-UCL.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# Genevisible	Q9NSA0	HS
# HGNC	HGNC:18120	SLC22A11
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# MIM	607097	gene
# Organism	S22AB_HUMAN	Homo sapiens (Human)
# PROSITE	PS50850	MFS
# PTM	S22AB_HUMAN	N-glycosylated. Contains several complex-type N-glycans. {ECO 0000269|PubMed 15576633}. 
# Pfam	PF00083	Sugar_tr
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-561048	Organic anion transport
# RecName	S22AB_HUMAN	Solute carrier family 22 member 11
# RefSeq	NP_001294914	NM_001307985.1. [Q9NSA0-2]
# RefSeq	NP_060954	NM_018484.3. [Q9NSA0-1]
# SEQUENCE CAUTION	Sequence=BAC11483.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S22AB_HUMAN	Cell membrane {ECO 0000269|PubMed 15291761, ECO 0000269|PubMed 15576633}; Multi-pass membrane protein {ECO 0000269|PubMed 15291761, ECO 0000269|PubMed 15576633}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.19.10	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	Detected in placenta and kidney. {ECO:0000269|PubMed	10660625}. 
# UCSC	uc001oai	human. [Q9NSA0-1]
# eggNOG	COG0477	LUCA
# eggNOG	KOG0255	Eukaryota
BLAST	swissprot:S22AB_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S22AB_HUMAN
BioCyc	ZFISH:ENSG00000168065-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000168065-MONOMER
COXPRESdb	55867	http://coxpresdb.jp/data/gene/55867.shtml
CleanEx	HS_SLC22A11	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC22A11
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/BJ20040751	http://dx.doi.org/10.1042/BJ20040751
DOI	10.1074/jbc.275.6.4507	http://dx.doi.org/10.1074/jbc.275.6.4507
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1124/mol.104.007583	http://dx.doi.org/10.1124/mol.104.007583
DOI	10.1124/mol.65.5.1141	http://dx.doi.org/10.1124/mol.65.5.1141
DrugBank	DB00168	http://www.drugbank.ca/drugs/DB00168
DrugBank	DB00175	http://www.drugbank.ca/drugs/DB00175
DrugBank	DB00254	http://www.drugbank.ca/drugs/DB00254
DrugBank	DB00286	http://www.drugbank.ca/drugs/DB00286
DrugBank	DB00328	http://www.drugbank.ca/drugs/DB00328
DrugBank	DB00345	http://www.drugbank.ca/drugs/DB00345
DrugBank	DB00456	http://www.drugbank.ca/drugs/DB00456
DrugBank	DB00493	http://www.drugbank.ca/drugs/DB00493
DrugBank	DB00495	http://www.drugbank.ca/drugs/DB00495
DrugBank	DB00501	http://www.drugbank.ca/drugs/DB00501
DrugBank	DB00554	http://www.drugbank.ca/drugs/DB00554
DrugBank	DB00563	http://www.drugbank.ca/drugs/DB00563
DrugBank	DB00586	http://www.drugbank.ca/drugs/DB00586
DrugBank	DB00595	http://www.drugbank.ca/drugs/DB00595
DrugBank	DB00695	http://www.drugbank.ca/drugs/DB00695
DrugBank	DB00759	http://www.drugbank.ca/drugs/DB00759
DrugBank	DB00783	http://www.drugbank.ca/drugs/DB00783
DrugBank	DB00812	http://www.drugbank.ca/drugs/DB00812
DrugBank	DB00887	http://www.drugbank.ca/drugs/DB00887
DrugBank	DB00917	http://www.drugbank.ca/drugs/DB00917
DrugBank	DB00936	http://www.drugbank.ca/drugs/DB00936
DrugBank	DB01009	http://www.drugbank.ca/drugs/DB01009
DrugBank	DB01017	http://www.drugbank.ca/drugs/DB01017
DrugBank	DB01032	http://www.drugbank.ca/drugs/DB01032
DrugBank	DB01050	http://www.drugbank.ca/drugs/DB01050
DrugBank	DB01051	http://www.drugbank.ca/drugs/DB01051
DrugBank	DB01053	http://www.drugbank.ca/drugs/DB01053
DrugBank	DB01160	http://www.drugbank.ca/drugs/DB01160
DrugBank	DB01212	http://www.drugbank.ca/drugs/DB01212
DrugBank	DB01326	http://www.drugbank.ca/drugs/DB01326
DrugBank	DB01327	http://www.drugbank.ca/drugs/DB01327
DrugBank	DB01329	http://www.drugbank.ca/drugs/DB01329
EMBL	AB026116	http://www.ebi.ac.uk/ena/data/view/AB026116
EMBL	AC044790	http://www.ebi.ac.uk/ena/data/view/AC044790
EMBL	AK075224	http://www.ebi.ac.uk/ena/data/view/AK075224
EMBL	AK129930	http://www.ebi.ac.uk/ena/data/view/AK129930
EMBL	AK222869	http://www.ebi.ac.uk/ena/data/view/AK222869
EMBL	AK290791	http://www.ebi.ac.uk/ena/data/view/AK290791
EMBL	BC034384	http://www.ebi.ac.uk/ena/data/view/BC034384
EMBL	CH471076	http://www.ebi.ac.uk/ena/data/view/CH471076
Ensembl	ENST00000301891	http://www.ensembl.org/id/ENST00000301891
Ensembl	ENST00000377585	http://www.ensembl.org/id/ENST00000377585
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0009897	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009897
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0005452	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005452
GO_function	GO:0008514	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008514
GO_function	GO:0015347	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015347
GO_process	GO:0015711	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015711
GO_process	GO:0043252	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043252
GO_process	GO:0046415	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046415
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GeneCards	SLC22A11	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC22A11
GeneID	55867	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55867
GeneTree	ENSGT00760000118852	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118852
HGNC	HGNC:18120	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18120
HOGENOM	HOG000234569	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234569&db=HOGENOM6
HOVERGEN	HBG108433	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108433&db=HOVERGEN
HPA	HPA026076	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA026076
InParanoid	Q9NSA0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NSA0
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	55867	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55867
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:55867	http://www.genome.jp/dbget-bin/www_bget?hsa:55867
KEGG_Orthology	KO:K08207	http://www.genome.jp/dbget-bin/www_bget?KO:K08207
MIM	607097	http://www.ncbi.nlm.nih.gov/omim/607097
OMA	CLVIPSQ	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CLVIPSQ
OrthoDB	EOG091G05EB	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G05EB
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:S22AB_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S22AB_HUMAN
PSORT-B	swissprot:S22AB_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S22AB_HUMAN
PSORT2	swissprot:S22AB_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S22AB_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
PharmGKB	PA38295	http://www.pharmgkb.org/do/serve?objId=PA38295&objCls=Gene
Phobius	swissprot:S22AB_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S22AB_HUMAN
PhylomeDB	Q9NSA0	http://phylomedb.org/?seqid=Q9NSA0
ProteinModelPortal	Q9NSA0	http://www.proteinmodelportal.org/query/uniprot/Q9NSA0
PubMed	10660625	http://www.ncbi.nlm.nih.gov/pubmed/10660625
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15102942	http://www.ncbi.nlm.nih.gov/pubmed/15102942
PubMed	15291761	http://www.ncbi.nlm.nih.gov/pubmed/15291761
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15576633	http://www.ncbi.nlm.nih.gov/pubmed/15576633
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
Reactome	R-HSA-561048	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-561048
RefSeq	NP_001294914	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001294914
RefSeq	NP_060954	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060954
STRING	9606.ENSP00000301891	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000301891&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.19.10	http://www.tcdb.org/search/result.php?tc=2.A.1.19.10
UCSC	uc001oai	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001oai&org=rat
UniGene	Hs.220844	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.220844
UniGene	Hs.657603	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.657603
UniProtKB	S22AB_HUMAN	http://www.uniprot.org/uniprot/S22AB_HUMAN
UniProtKB-AC	Q9NSA0	http://www.uniprot.org/uniprot/Q9NSA0
charge	swissprot:S22AB_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S22AB_HUMAN
eggNOG	COG0477	http://eggnogapi.embl.de/nog_data/html/tree/COG0477
eggNOG	KOG0255	http://eggnogapi.embl.de/nog_data/html/tree/KOG0255
epestfind	swissprot:S22AB_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S22AB_HUMAN
garnier	swissprot:S22AB_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S22AB_HUMAN
helixturnhelix	swissprot:S22AB_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S22AB_HUMAN
hmoment	swissprot:S22AB_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S22AB_HUMAN
iep	swissprot:S22AB_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S22AB_HUMAN
inforesidue	swissprot:S22AB_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S22AB_HUMAN
neXtProt	NX_Q9NSA0	http://www.nextprot.org/db/entry/NX_Q9NSA0
octanol	swissprot:S22AB_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S22AB_HUMAN
pepcoil	swissprot:S22AB_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S22AB_HUMAN
pepdigest	swissprot:S22AB_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S22AB_HUMAN
pepinfo	swissprot:S22AB_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S22AB_HUMAN
pepnet	swissprot:S22AB_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S22AB_HUMAN
pepstats	swissprot:S22AB_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S22AB_HUMAN
pepwheel	swissprot:S22AB_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S22AB_HUMAN
pepwindow	swissprot:S22AB_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S22AB_HUMAN
sigcleave	swissprot:S22AB_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S22AB_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SC5AA_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=IF2; IsoId=A0PJK1-1; Sequence=Displayed; Name=2; Synonyms=IF3; IsoId=A0PJK1-2; Sequence=VSP_029417; Name=3; IsoId=A0PJK1-3; Sequence=VSP_029416, VSP_029417, VSP_029418, VSP_029419; Note=No experimental confirmation available.; Name=4; Synonyms=IF1; IsoId=A0PJK1-4; Sequence=VSP_029418; Name=5; Synonyms=IF4; IsoId=A0PJK1-5; Sequence=VSP_045061; 
# AltName	SC5AA_HUMAN	Solute carrier family 5 member 10
# CCDS	CCDS11201	-. [A0PJK1-4]
# CCDS	CCDS42275	-. [A0PJK1-1]
# CCDS	CCDS59277	-. [A0PJK1-5]
# CCDS	CCDS59278	-. [A0PJK1-2]
# CCDS	CCDS74008	-. [A0PJK1-3]
# ChiTaRS	SLC5A10	human
# Ensembl	ENST00000317977	ENSP00000324346; ENSG00000154025. [A0PJK1-3]
# Ensembl	ENST00000395643	ENSP00000379005; ENSG00000154025. [A0PJK1-2]
# Ensembl	ENST00000395645	ENSP00000379007; ENSG00000154025. [A0PJK1-1]
# Ensembl	ENST00000395647	ENSP00000379008; ENSG00000154025. [A0PJK1-4]
# Ensembl	ENST00000417251	ENSP00000401875; ENSG00000154025. [A0PJK1-5]
# FUNCTION	SC5AA_HUMAN	High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose. {ECO 0000269|PubMed 22212718}. 
# GO_component	GO:0005887	integral component of plasma membrane; IBA:GO_Central.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0015293	symporter activity; IBA:GO_Central.
# GO_process	GO:0006814	sodium ion transport; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# Genevisible	A0PJK1	HS
# HGNC	HGNC:23155	SLC5A10
# InterPro	IPR001734	Na/solute_symporter
# InterPro	IPR018212	Na/solute_symporter_CS
# KEGG_Brite	ko02001	Solute carrier family
# Organism	SC5AA_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11819	PTHR11819
# PROSITE	PS00457	NA_SOLUT_SYMP_2
# PROSITE	PS50283	NA_SOLUT_SYMP_3
# Pfam	PF00474	SSF
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-189200	Hexose transport
# RecName	SC5AA_HUMAN	Sodium/glucose cotransporter 5
# RefSeq	NP_001035915	NM_001042450.2. [A0PJK1-1]
# RefSeq	NP_001257577	NM_001270648.1. [A0PJK1-2]
# RefSeq	NP_001257578	NM_001270649.1. [A0PJK1-5]
# RefSeq	NP_001269346	NM_001282417.1. [A0PJK1-3]
# RefSeq	NP_689564	NM_152351.4. [A0PJK1-4]
# SEQUENCE CAUTION	Sequence=BAB71619.1; Type=Frameshift; Positions=156; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	SC5AA_HUMAN	Cell membrane {ECO 0000269|PubMed 22212718}; Multi-pass membrane protein {ECO 0000269|PubMed 22212718}. 
# TCDB	2.A.21.3.15:the solute	sodium symporter (sss) family
# TIGRFAMs	TIGR00813	sss
# TISSUE SPECIFICITY	Seems to be exclusively expressed in kidney. {ECO:0000269|PubMed	22212718}. 
# UCSC	uc002gur	human. [A0PJK1-1]
# eggNOG	COG4146	LUCA
# eggNOG	ENOG410IP49	Eukaryota
BLAST	swissprot:SC5AA_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SC5AA_HUMAN
COXPRESdb	125206	http://coxpresdb.jp/data/gene/125206.shtml
CleanEx	HS_SLC5A10	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC5A10
DOI	10.1016/j.febslet.2011.12.027	http://dx.doi.org/10.1016/j.febslet.2011.12.027
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
EMBL	AC003957	http://www.ebi.ac.uk/ena/data/view/AC003957
EMBL	AC090286	http://www.ebi.ac.uk/ena/data/view/AC090286
EMBL	AK057946	http://www.ebi.ac.uk/ena/data/view/AK057946
EMBL	AK298345	http://www.ebi.ac.uk/ena/data/view/AK298345
EMBL	BC034380	http://www.ebi.ac.uk/ena/data/view/BC034380
EMBL	BC039868	http://www.ebi.ac.uk/ena/data/view/BC039868
EMBL	BC062617	http://www.ebi.ac.uk/ena/data/view/BC062617
Ensembl	ENST00000317977	http://www.ensembl.org/id/ENST00000317977
Ensembl	ENST00000395643	http://www.ensembl.org/id/ENST00000395643
Ensembl	ENST00000395645	http://www.ensembl.org/id/ENST00000395645
Ensembl	ENST00000395647	http://www.ensembl.org/id/ENST00000395647
Ensembl	ENST00000417251	http://www.ensembl.org/id/ENST00000417251
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GeneCards	SLC5A10	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC5A10
GeneID	125206	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=125206
GeneTree	ENSGT00760000118955	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118955
H-InvDB	HIX0018725	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0018725
HGNC	HGNC:23155	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:23155
HOGENOM	HOG000025422	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000025422&db=HOGENOM6
HOVERGEN	HBG052859	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052859&db=HOVERGEN
HPA	HPA052014	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA052014
InParanoid	A0PJK1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=A0PJK1
InterPro	IPR001734	http://www.ebi.ac.uk/interpro/entry/IPR001734
InterPro	IPR018212	http://www.ebi.ac.uk/interpro/entry/IPR018212
Jabion	125206	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=125206
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:125206	http://www.genome.jp/dbget-bin/www_bget?hsa:125206
KEGG_Orthology	KO:K14390	http://www.genome.jp/dbget-bin/www_bget?KO:K14390
MINT	MINT-4722994	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4722994
OMA	IFWQRAN	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IFWQRAN
OrthoDB	EOG091G077U	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G077U
PANTHER	PTHR11819	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11819
PROSITE	PS00457	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00457
PROSITE	PS50283	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50283
PSORT	swissprot:SC5AA_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SC5AA_HUMAN
PSORT-B	swissprot:SC5AA_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SC5AA_HUMAN
PSORT2	swissprot:SC5AA_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SC5AA_HUMAN
Pfam	PF00474	http://pfam.xfam.org/family/PF00474
PharmGKB	PA134940254	http://www.pharmgkb.org/do/serve?objId=PA134940254&objCls=Gene
Phobius	swissprot:SC5AA_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SC5AA_HUMAN
PhylomeDB	A0PJK1	http://phylomedb.org/?seqid=A0PJK1
ProteinModelPortal	A0PJK1	http://www.proteinmodelportal.org/query/uniprot/A0PJK1
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	22212718	http://www.ncbi.nlm.nih.gov/pubmed/22212718
Reactome	R-HSA-189200	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-189200
RefSeq	NP_001035915	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001035915
RefSeq	NP_001257577	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001257577
RefSeq	NP_001257578	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001257578
RefSeq	NP_001269346	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269346
RefSeq	NP_689564	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_689564
STRING	9606.ENSP00000379008	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000379008&targetmode=cogs
TCDB	2.A.21.3.15	http://www.tcdb.org/search/result.php?tc=2.A.21.3.15
TIGRFAMs	TIGR00813	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00813
UCSC	uc002gur	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002gur&org=rat
UniGene	Hs.462418	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.462418
UniProtKB	SC5AA_HUMAN	http://www.uniprot.org/uniprot/SC5AA_HUMAN
UniProtKB-AC	A0PJK1	http://www.uniprot.org/uniprot/A0PJK1
charge	swissprot:SC5AA_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SC5AA_HUMAN
eggNOG	COG4146	http://eggnogapi.embl.de/nog_data/html/tree/COG4146
eggNOG	ENOG410IP49	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IP49
epestfind	swissprot:SC5AA_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SC5AA_HUMAN
garnier	swissprot:SC5AA_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SC5AA_HUMAN
helixturnhelix	swissprot:SC5AA_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SC5AA_HUMAN
hmoment	swissprot:SC5AA_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SC5AA_HUMAN
iep	swissprot:SC5AA_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SC5AA_HUMAN
inforesidue	swissprot:SC5AA_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SC5AA_HUMAN
neXtProt	NX_A0PJK1	http://www.nextprot.org/db/entry/NX_A0PJK1
octanol	swissprot:SC5AA_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SC5AA_HUMAN
pepcoil	swissprot:SC5AA_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SC5AA_HUMAN
pepdigest	swissprot:SC5AA_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SC5AA_HUMAN
pepinfo	swissprot:SC5AA_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SC5AA_HUMAN
pepnet	swissprot:SC5AA_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SC5AA_HUMAN
pepstats	swissprot:SC5AA_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SC5AA_HUMAN
pepwheel	swissprot:SC5AA_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SC5AA_HUMAN
pepwindow	swissprot:SC5AA_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SC5AA_HUMAN
sigcleave	swissprot:SC5AA_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SC5AA_HUMAN
## Database	ID	URL or Descriptions
# AltName	CCGL_HUMAN	Neuronal voltage-gated calcium channel gamma-like subunit
# AltName	CCGL_HUMAN	Transmembrane protein 37
# BioGrid	126681	6
# ChiTaRS	TMEM37	human
# Ensembl	ENST00000306406	ENSP00000303148; ENSG00000171227
# ExpressionAtlas	Q8WXS4	baseline and differential
# FUNCTION	CCGL_HUMAN	Thought to stabilize the calcium channel in an inactivated (closed) state. Modulates calcium current when coexpressed with CACNA1G (By similarity). {ECO 0000250|UniProtKB Q9JJV3}. 
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005244	voltage-gated ion channel activity; IEA:UniProtKB-KW.
# GO_function	GO:0005262	calcium channel activity; IEA:UniProtKB-KW.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# Genevisible	Q8WXS4	HS
# HGNC	HGNC:18216	TMEM37
# IntAct	Q8WXS4	6
# InterPro	IPR029372	Tmem37
# Organism	CCGL_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR31767:SF0	PTHR31767:SF0
# Pfam	PF15108	TMEM37
# Proteomes	UP000005640	Chromosome 2
# RecName	CCGL_HUMAN	Voltage-dependent calcium channel gamma-like subunit
# RefSeq	NP_899063	NM_183240.2
# SIMILARITY	Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. {ECO	0000255}.
# SUBCELLULAR LOCATION	CCGL_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUBUNIT	The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. {ECO	0000250}. 
# UCSC	uc002tly	human
# eggNOG	ENOG410IE8N	Eukaryota
# eggNOG	ENOG4111WUN	LUCA
BLAST	swissprot:CCGL_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CCGL_HUMAN
BioCyc	ZFISH:ENSG00000171227-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000171227-MONOMER
COXPRESdb	140738	http://coxpresdb.jp/data/gene/140738.shtml
CleanEx	HS_TMEM37	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TMEM37
DOI	10.1016/S0378-1119(01)00738-7	http://dx.doi.org/10.1016/S0378-1119(01)00738-7
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
EMBL	AC013275	http://www.ebi.ac.uk/ena/data/view/AC013275
EMBL	AF361356	http://www.ebi.ac.uk/ena/data/view/AF361356
Ensembl	ENST00000306406	http://www.ensembl.org/id/ENST00000306406
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005244	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005244
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GeneCards	TMEM37	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TMEM37
GeneID	140738	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=140738
GeneTree	ENSGT00390000006225	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000006225
H-InvDB	HIX0002409	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0002409
HGNC	HGNC:18216	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18216
HOGENOM	HOG000111447	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000111447&db=HOGENOM6
HOVERGEN	HBG028482	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG028482&db=HOVERGEN
HPA	HPA053794	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA053794
InParanoid	Q8WXS4	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8WXS4
IntAct	Q8WXS4	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q8WXS4*
InterPro	IPR029372	http://www.ebi.ac.uk/interpro/entry/IPR029372
Jabion	140738	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=140738
KEGG_Gene	hsa:140738	http://www.genome.jp/dbget-bin/www_bget?hsa:140738
PANTHER	PTHR31767:SF0	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31767:SF0
PSORT	swissprot:CCGL_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CCGL_HUMAN
PSORT-B	swissprot:CCGL_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CCGL_HUMAN
PSORT2	swissprot:CCGL_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CCGL_HUMAN
Pfam	PF15108	http://pfam.xfam.org/family/PF15108
PharmGKB	PA134897608	http://www.pharmgkb.org/do/serve?objId=PA134897608&objCls=Gene
Phobius	swissprot:CCGL_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CCGL_HUMAN
PhylomeDB	Q8WXS4	http://phylomedb.org/?seqid=Q8WXS4
ProteinModelPortal	Q8WXS4	http://www.proteinmodelportal.org/query/uniprot/Q8WXS4
PubMed	11738816	http://www.ncbi.nlm.nih.gov/pubmed/11738816
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
RefSeq	NP_899063	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_899063
STRING	9606.ENSP00000303148	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000303148&targetmode=cogs
UCSC	uc002tly	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002tly&org=rat
UniGene	Hs.26216	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.26216
UniProtKB	CCGL_HUMAN	http://www.uniprot.org/uniprot/CCGL_HUMAN
UniProtKB-AC	Q8WXS4	http://www.uniprot.org/uniprot/Q8WXS4
charge	swissprot:CCGL_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CCGL_HUMAN
eggNOG	ENOG410IE8N	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IE8N
eggNOG	ENOG4111WUN	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111WUN
epestfind	swissprot:CCGL_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CCGL_HUMAN
garnier	swissprot:CCGL_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CCGL_HUMAN
helixturnhelix	swissprot:CCGL_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CCGL_HUMAN
hmoment	swissprot:CCGL_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CCGL_HUMAN
iep	swissprot:CCGL_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CCGL_HUMAN
inforesidue	swissprot:CCGL_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CCGL_HUMAN
neXtProt	NX_Q8WXS4	http://www.nextprot.org/db/entry/NX_Q8WXS4
octanol	swissprot:CCGL_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CCGL_HUMAN
pepcoil	swissprot:CCGL_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CCGL_HUMAN
pepdigest	swissprot:CCGL_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CCGL_HUMAN
pepinfo	swissprot:CCGL_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CCGL_HUMAN
pepnet	swissprot:CCGL_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CCGL_HUMAN
pepstats	swissprot:CCGL_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CCGL_HUMAN
pepwheel	swissprot:CCGL_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CCGL_HUMAN
pepwindow	swissprot:CCGL_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CCGL_HUMAN
sigcleave	swissprot:CCGL_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CCGL_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	NCS1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P62166-1; Sequence=Displayed; Name=2; IsoId=P62166-2; Sequence=VSP_046312; Note=No experimental confirmation available.; 
# AltName	NCS1_HUMAN	Frequenin homolog
# AltName	NCS1_HUMAN	Frequenin-like protein
# AltName	NCS1_HUMAN	Frequenin-like ubiquitous protein
# BioGrid	116985	29
# CCDS	CCDS6932	-. [P62166-1]
# CCDS	CCDS78448	-. [P62166-2]
# CDD	cd00051	EFh; 2
# ChiTaRS	NCS1	human
# Ensembl	ENST00000372398	ENSP00000361475; ENSG00000107130. [P62166-1]
# Ensembl	ENST00000630865	ENSP00000486695; ENSG00000107130. [P62166-2]
# ExpressionAtlas	P62166	baseline and differential
# FUNCTION	NCS1_HUMAN	Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N- type voltage-gated calcium channel (By similarity). {ECO 0000250}. 
# GO_component	GO:0005737	cytoplasm; IDA:UniProtKB.
# GO_component	GO:0005794	Golgi apparatus; IEA:UniProtKB-SubCell.
# GO_component	GO:0005829	cytosol; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0014069	postsynaptic density; IEA:UniProtKB-SubCell.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030424	axon; IEA:Ensembl.
# GO_component	GO:0030425	dendrite; IEA:Ensembl.
# GO_component	GO:0031045	dense core granule; IEA:Ensembl.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-KW.
# GO_component	GO:0048471	perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0000287	magnesium ion binding; IEA:Ensembl.
# GO_function	GO:0005245	voltage-gated calcium channel activity; ISS:UniProtKB.
# GO_function	GO:0005509	calcium ion binding; TAS:UniProtKB.
# GO_process	GO:0010975	regulation of neuron projection development; ISS:UniProtKB.
# GO_process	GO:0045921	positive regulation of exocytosis; IEA:Ensembl.
# GO_process	GO:0048015	phosphatidylinositol-mediated signaling; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# Gene3D	1.10.238.10	-; 3.
# Genevisible	P62166	HS
# HGNC	HGNC:3953	NCS1
# INTERACTION	NCS1_HUMAN	Q4ZH49 DTX2; NbExp=5; IntAct=EBI-746987, EBI-10192429; Q86UW9 DTX2; NbExp=7; IntAct=EBI-746987, EBI-740376; P41271 NBL1; NbExp=3; IntAct=EBI-746987, EBI-10208650; 
# IntAct	P62166	7
# InterPro	IPR002048	EF_hand_dom
# InterPro	IPR011992	EF-hand-dom_pair
# InterPro	IPR018247	EF_Hand_1_Ca_BS
# InterPro	IPR028846	Recoverin
# MIM	603315	gene
# MISCELLANEOUS	NCS1_HUMAN	Binds 3 calcium ions via the second, third and fourth EF-hand. 
# Organism	NCS1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR23055	PTHR23055
# PDB	1G8I	X-ray; 1.90 A; A/B=1-190
# PDB	2LCP	NMR; -; A=1-190
# PDB	4GUK	X-ray; 1.75 A; A/B/C/D=6-188
# PROSITE	PS00018	EF_HAND_1; 3
# PROSITE	PS50222	EF_HAND_2; 3
# Pfam	PF00036	EF-hand_1
# Pfam	PF13499	EF-hand_7
# Proteomes	UP000005640	Chromosome 9
# RecName	NCS1_HUMAN	Neuronal calcium sensor 1
# RefSeq	NP_001122298	NM_001128826.1. [P62166-2]
# RefSeq	NP_055101	NM_014286.3. [P62166-1]
# SIMILARITY	Belongs to the recoverin family. {ECO	0000305}. 
# SIMILARITY	Contains 4 EF-hand domains. {ECO:0000255|PROSITE- ProRule	PRU00448}.
# SMART	SM00054	EFh; 3
# SUBCELLULAR LOCATION	NCS1_HUMAN	Golgi apparatus {ECO 0000269|PubMed 17555535}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO 0000305}. Cytoplasm, perinuclear region {ECO 0000269|PubMed 11092894, ECO 0000269|PubMed 17555535}. Cytoplasm {ECO 0000250|UniProtKB P62168}. Cell membrane {ECO 0000269|PubMed 17555535}; Peripheral membrane protein. Membrane {ECO 0000250|UniProtKB P62168}; Lipid-anchor {ECO 0000305}. Note=Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions. {ECO 0000305, ECO 0000305|PubMed 17555535}. 
# SUBUNIT	NCS1_HUMAN	Interacts with KCND2. Interacts in a calcium-independent manner with PI4KB. This binding competes with CALN2/CABP7 binding to PI4KB (By similarity). Interacts with ARF1, ARF3, ARF5 and ARF6. Interacts in a calcium-dependent manner with PICK1 (via AH domain) (By similarity). Interacts with IL1RAPL1. {ECO 0000250, ECO 0000269|PubMed 11606724, ECO 0000269|PubMed 12783849, ECO 0000269|PubMed 17555535}. 
# SUPFAM	SSF47473	SSF47473
# TopDownProteomics	P62166-1	-. [P62166-1]
# UCSC	uc004bzi	human. [P62166-1]
# eggNOG	COG5126	LUCA
# eggNOG	KOG0044	Eukaryota
BLAST	swissprot:NCS1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NCS1_HUMAN
BioCyc	ZFISH:ENSG00000107130-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000107130-MONOMER
COXPRESdb	23413	http://coxpresdb.jp/data/gene/23413.shtml
CleanEx	HS_FREQ	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_FREQ
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
DOI	10.1038/ncomms5919	http://dx.doi.org/10.1038/ncomms5919
DOI	10.1073/pnas.221168498	http://dx.doi.org/10.1073/pnas.221168498
DOI	10.1074/jbc.M009373200	http://dx.doi.org/10.1074/jbc.M009373200
DOI	10.1093/hmg/ddg147	http://dx.doi.org/10.1093/hmg/ddg147
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1600-0854.2007.00594.x	http://dx.doi.org/10.1111/j.1600-0854.2007.00594.x
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF134479	http://www.ebi.ac.uk/ena/data/view/AF134479
EMBL	AF186409	http://www.ebi.ac.uk/ena/data/view/AF186409
EMBL	AL360004	http://www.ebi.ac.uk/ena/data/view/AL360004
EMBL	BC004856	http://www.ebi.ac.uk/ena/data/view/BC004856
EMBL	BQ880305	http://www.ebi.ac.uk/ena/data/view/BQ880305
EMBL	X84048	http://www.ebi.ac.uk/ena/data/view/X84048
Ensembl	ENST00000372398	http://www.ensembl.org/id/ENST00000372398
Ensembl	ENST00000630865	http://www.ensembl.org/id/ENST00000630865
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0014069	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014069
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030424	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030424
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0031045	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031045
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_component	GO:0048471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048471
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0000287	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0005509	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509
GO_process	GO:0010975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010975
GO_process	GO:0045921	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045921
GO_process	GO:0048015	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048015
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	1.10.238.10	http://www.cathdb.info/version/latest/superfamily/1.10.238.10
GeneCards	NCS1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=NCS1
GeneID	23413	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23413
GeneTree	ENSGT00760000118820	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118820
HGNC	HGNC:3953	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:3953
HOGENOM	HOG000233019	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233019&db=HOGENOM6
HOVERGEN	HBG108179	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG108179&db=HOVERGEN
HPA	CAB018587	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB018587
HPA	HPA019713	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA019713
InParanoid	P62166	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P62166
IntAct	P62166	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P62166*
InterPro	IPR002048	http://www.ebi.ac.uk/interpro/entry/IPR002048
InterPro	IPR011992	http://www.ebi.ac.uk/interpro/entry/IPR011992
InterPro	IPR018247	http://www.ebi.ac.uk/interpro/entry/IPR018247
InterPro	IPR028846	http://www.ebi.ac.uk/interpro/entry/IPR028846
Jabion	23413	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=23413
KEGG_Gene	hsa:23413	http://www.genome.jp/dbget-bin/www_bget?hsa:23413
MIM	603315	http://www.ncbi.nlm.nih.gov/omim/603315
MINT	MINT-1436213	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1436213
OMA	FHEFIRA	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FHEFIRA
OrthoDB	EOG091G11T4	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G11T4
PANTHER	PTHR23055	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23055
PDB	1G8I	http://www.ebi.ac.uk/pdbe-srv/view/entry/1G8I
PDB	2LCP	http://www.ebi.ac.uk/pdbe-srv/view/entry/2LCP
PDB	4GUK	http://www.ebi.ac.uk/pdbe-srv/view/entry/4GUK
PDBsum	1G8I	http://www.ebi.ac.uk/pdbsum/1G8I
PDBsum	2LCP	http://www.ebi.ac.uk/pdbsum/2LCP
PDBsum	4GUK	http://www.ebi.ac.uk/pdbsum/4GUK
PROSITE	PS00018	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00018
PROSITE	PS50222	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50222
PSORT	swissprot:NCS1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NCS1_HUMAN
PSORT-B	swissprot:NCS1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NCS1_HUMAN
PSORT2	swissprot:NCS1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NCS1_HUMAN
Pfam	PF00036	http://pfam.xfam.org/family/PF00036
Pfam	PF13499	http://pfam.xfam.org/family/PF13499
PharmGKB	PA28371	http://www.pharmgkb.org/do/serve?objId=PA28371&objCls=Gene
Phobius	swissprot:NCS1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NCS1_HUMAN
PhylomeDB	P62166	http://phylomedb.org/?seqid=P62166
ProteinModelPortal	P62166	http://www.proteinmodelportal.org/query/uniprot/P62166
PubMed	11092894	http://www.ncbi.nlm.nih.gov/pubmed/11092894
PubMed	11606724	http://www.ncbi.nlm.nih.gov/pubmed/11606724
PubMed	12783849	http://www.ncbi.nlm.nih.gov/pubmed/12783849
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17555535	http://www.ncbi.nlm.nih.gov/pubmed/17555535
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	25255805	http://www.ncbi.nlm.nih.gov/pubmed/25255805
RefSeq	NP_001122298	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001122298
RefSeq	NP_055101	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055101
SMART	SM00054	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00054
SMR	P62166	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P62166
STRING	9606.ENSP00000361475	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000361475&targetmode=cogs
SUPFAM	SSF47473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47473
UCSC	uc004bzi	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004bzi&org=rat
UniGene	Hs.642946	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.642946
UniGene	Hs.714951	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.714951
UniProtKB	NCS1_HUMAN	http://www.uniprot.org/uniprot/NCS1_HUMAN
UniProtKB-AC	P62166	http://www.uniprot.org/uniprot/P62166
charge	swissprot:NCS1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NCS1_HUMAN
eggNOG	COG5126	http://eggnogapi.embl.de/nog_data/html/tree/COG5126
eggNOG	KOG0044	http://eggnogapi.embl.de/nog_data/html/tree/KOG0044
epestfind	swissprot:NCS1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NCS1_HUMAN
garnier	swissprot:NCS1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NCS1_HUMAN
helixturnhelix	swissprot:NCS1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NCS1_HUMAN
hmoment	swissprot:NCS1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NCS1_HUMAN
iep	swissprot:NCS1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NCS1_HUMAN
inforesidue	swissprot:NCS1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NCS1_HUMAN
neXtProt	NX_P62166	http://www.nextprot.org/db/entry/NX_P62166
octanol	swissprot:NCS1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NCS1_HUMAN
pepcoil	swissprot:NCS1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NCS1_HUMAN
pepdigest	swissprot:NCS1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NCS1_HUMAN
pepinfo	swissprot:NCS1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NCS1_HUMAN
pepnet	swissprot:NCS1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NCS1_HUMAN
pepstats	swissprot:NCS1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NCS1_HUMAN
pepwheel	swissprot:NCS1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NCS1_HUMAN
pepwindow	swissprot:NCS1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NCS1_HUMAN
sigcleave	swissprot:NCS1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NCS1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	S61A1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P61619-1; Sequence=Displayed; Name=3; IsoId=P61619-3; Sequence=VSP_013747; Note=No experimental confirmation available.; 
# BioGrid	118968	64
# CCDS	CCDS3046	-. [P61619-1]
# ChiTaRS	SEC61A1	human
# Ensembl	ENST00000243253	ENSP00000243253; ENSG00000058262. [P61619-1]
# Ensembl	ENST00000424880	ENSP00000411445; ENSG00000058262. [P61619-3]
# ExpressionAtlas	P61619	baseline and differential
# FUNCTION	S61A1_HUMAN	Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane- bound ribosomes, either directly or through adapter proteins. 
# GO_component	GO:0005791	rough endoplasmic reticulum; IEA:Ensembl.
# GO_component	GO:0005829	cytosol; TAS:Reactome.
# GO_component	GO:0016020	membrane; IDA:MGI.
# GO_component	GO:0030176	integral component of endoplasmic reticulum membrane; ISS:UniProtKB.
# GO_function	GO:0022857	transmembrane transporter activity; IEA:Ensembl.
# GO_function	GO:0043022	ribosome binding; ISS:UniProtKB.
# GO_process	GO:0006614	SRP-dependent cotranslational protein targeting to membrane; IMP:MGI.
# GO_process	GO:0006620	posttranslational protein targeting to membrane; IMP:MGI.
# GO_process	GO:0007029	endoplasmic reticulum organization; IMP:MGI.
# GO_process	GO:0016049	cell growth; IMP:MGI.
# GO_process	GO:0034341	response to interferon-gamma; IEA:Ensembl.
# GO_process	GO:0036498	IRE1-mediated unfolded protein response; TAS:Reactome.
# GO_process	GO:0045047	protein targeting to ER; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005829	cytosol
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006605	protein targeting
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0040007	growth
# GOslim_process	GO:0061024	membrane organization
# Gene3D	1.10.3370.10	-; 1.
# Genevisible	P61619	HS
# HGNC	HGNC:18276	SEC61A1
# INTERACTION	S61A1_HUMAN	P27824 CANX; NbExp=3; IntAct=EBI-358919, EBI-355947; P11021 HSPA5; NbExp=3; IntAct=EBI-358919, EBI-354921; 
# IntAct	P61619	35
# InterPro	IPR002208	SecY/SEC61-alpha
# InterPro	IPR019561	Translocon_Sec61/SecY_plug_dom
# InterPro	IPR023201	SecY_su_dom
# InterPro	IPR030659	SecY_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko02044	 M00401  Sec61 complex
# KEGG_Brite	ko02044	 Secretion system
# KEGG_Pathway	ko03060	Protein export
# KEGG_Pathway	ko04141	Protein processing in endoplasmic reticulum
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko05110	Vibrio cholerae infection
# MIM	609213	gene
# Organism	S61A1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10906	PTHR10906
# PIRSF	PIRSF004557	SecY
# PROSITE	PS00755	SECY_1
# PROSITE	PS00756	SECY_2
# Pfam	PF00344	SecY
# Pfam	PF10559	Plug_translocon
# Proteomes	UP000005640	Chromosome 3
# Reactome	R-HSA-1236974	ER-Phagosome pathway
# Reactome	R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane
# Reactome	R-HSA-381038	XBP1(S) activates chaperone genes
# RecName	S61A1_HUMAN	Protein transport protein Sec61 subunit alpha isoform 1
# RefSeq	NP_037468	NM_013336.3. [P61619-1]
# SEQUENCE CAUTION	Sequence=BAC11283.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11434.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the SecY/SEC61-alpha family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S61A1_HUMAN	Endoplasmic reticulum membrane; Multi-pass membrane protein. 
# SUBUNIT	S61A1_HUMAN	Heterotrimeric complex composed of SEC61-alpha, SEC61- beta and SEC61-gamma. 
# SUPFAM	SSF103491	SSF103491
# TCDB	3.A.5.9	the general secretory pathway (sec) family
# TIGRFAMs	TIGR00967	3a0501s007
# UCSC	uc003ekb	human. [P61619-1]
# eggNOG	COG0201	LUCA
# eggNOG	KOG1373	Eukaryota
BLAST	swissprot:S61A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S61A1_HUMAN
COXPRESdb	29927	http://coxpresdb.jp/data/gene/29927.shtml
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF077032	http://www.ebi.ac.uk/ena/data/view/AF077032
EMBL	AF084458	http://www.ebi.ac.uk/ena/data/view/AF084458
EMBL	AF346602	http://www.ebi.ac.uk/ena/data/view/AF346602
EMBL	AK074907	http://www.ebi.ac.uk/ena/data/view/AK074907
EMBL	AK074928	http://www.ebi.ac.uk/ena/data/view/AK074928
EMBL	AK075148	http://www.ebi.ac.uk/ena/data/view/AK075148
EMBL	AL831940	http://www.ebi.ac.uk/ena/data/view/AL831940
EMBL	AL832821	http://www.ebi.ac.uk/ena/data/view/AL832821
Ensembl	ENST00000243253	http://www.ensembl.org/id/ENST00000243253
Ensembl	ENST00000424880	http://www.ensembl.org/id/ENST00000424880
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005791	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005791
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0030176	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030176
GO_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GO_function	GO:0043022	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043022
GO_process	GO:0006614	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006614
GO_process	GO:0006620	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006620
GO_process	GO:0007029	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007029
GO_process	GO:0016049	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016049
GO_process	GO:0034341	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034341
GO_process	GO:0036498	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036498
GO_process	GO:0045047	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045047
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0040007	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040007
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
Gene3D	1.10.3370.10	http://www.cathdb.info/version/latest/superfamily/1.10.3370.10
GeneCards	SEC61A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SEC61A1
GeneID	29927	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29927
GeneTree	ENSGT00390000003721	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000003721
HGNC	HGNC:18276	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:18276
HOVERGEN	HBG055271	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG055271&db=HOVERGEN
HPA	CAB022076	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB022076
HPA	HPA045070	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA045070
InParanoid	P61619	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P61619
IntAct	P61619	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P61619*
InterPro	IPR002208	http://www.ebi.ac.uk/interpro/entry/IPR002208
InterPro	IPR019561	http://www.ebi.ac.uk/interpro/entry/IPR019561
InterPro	IPR023201	http://www.ebi.ac.uk/interpro/entry/IPR023201
InterPro	IPR030659	http://www.ebi.ac.uk/interpro/entry/IPR030659
Jabion	29927	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=29927
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko02044	http://www.genome.jp/dbget-bin/www_bget?ko02044
KEGG_Brite	ko02044	http://www.genome.jp/dbget-bin/www_bget?ko02044
KEGG_Gene	hsa:29927	http://www.genome.jp/dbget-bin/www_bget?hsa:29927
KEGG_Orthology	KO:K10956	http://www.genome.jp/dbget-bin/www_bget?KO:K10956
KEGG_Pathway	ko03060	http://www.genome.jp/kegg-bin/show_pathway?ko03060
KEGG_Pathway	ko04141	http://www.genome.jp/kegg-bin/show_pathway?ko04141
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko05110	http://www.genome.jp/kegg-bin/show_pathway?ko05110
MIM	609213	http://www.ncbi.nlm.nih.gov/omim/609213
MINT	MINT-1133988	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1133988
PANTHER	PTHR10906	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10906
PROSITE	PS00755	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00755
PROSITE	PS00756	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00756
PSORT	swissprot:S61A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S61A1_HUMAN
PSORT-B	swissprot:S61A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S61A1_HUMAN
PSORT2	swissprot:S61A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S61A1_HUMAN
Pfam	PF00344	http://pfam.xfam.org/family/PF00344
Pfam	PF10559	http://pfam.xfam.org/family/PF10559
PharmGKB	PA134901772	http://www.pharmgkb.org/do/serve?objId=PA134901772&objCls=Gene
Phobius	swissprot:S61A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S61A1_HUMAN
PhylomeDB	P61619	http://phylomedb.org/?seqid=P61619
ProteinModelPortal	P61619	http://www.proteinmodelportal.org/query/uniprot/P61619
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-1236974	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1236974
Reactome	R-HSA-1799339	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1799339
Reactome	R-HSA-381038	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-381038
RefSeq	NP_037468	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_037468
STRING	9606.ENSP00000243253	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000243253&targetmode=cogs
SUPFAM	SSF103491	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103491
TCDB	3.A.5.9	http://www.tcdb.org/search/result.php?tc=3.A.5.9
TIGRFAMs	TIGR00967	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00967
UCSC	uc003ekb	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003ekb&org=rat
UniGene	Hs.518236	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.518236
UniProtKB	S61A1_HUMAN	http://www.uniprot.org/uniprot/S61A1_HUMAN
UniProtKB-AC	P61619	http://www.uniprot.org/uniprot/P61619
charge	swissprot:S61A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S61A1_HUMAN
eggNOG	COG0201	http://eggnogapi.embl.de/nog_data/html/tree/COG0201
eggNOG	KOG1373	http://eggnogapi.embl.de/nog_data/html/tree/KOG1373
epestfind	swissprot:S61A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S61A1_HUMAN
garnier	swissprot:S61A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S61A1_HUMAN
helixturnhelix	swissprot:S61A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S61A1_HUMAN
hmoment	swissprot:S61A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S61A1_HUMAN
iep	swissprot:S61A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S61A1_HUMAN
inforesidue	swissprot:S61A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S61A1_HUMAN
neXtProt	NX_P61619	http://www.nextprot.org/db/entry/NX_P61619
octanol	swissprot:S61A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S61A1_HUMAN
pepcoil	swissprot:S61A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S61A1_HUMAN
pepdigest	swissprot:S61A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S61A1_HUMAN
pepinfo	swissprot:S61A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S61A1_HUMAN
pepnet	swissprot:S61A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S61A1_HUMAN
pepstats	swissprot:S61A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S61A1_HUMAN
pepwheel	swissprot:S61A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S61A1_HUMAN
pepwindow	swissprot:S61A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S61A1_HUMAN
sigcleave	swissprot:S61A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S61A1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	AT8A1_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Long; IsoId=Q9Y2Q0-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q9Y2Q0-2; Sequence=VSP_000431; Name=3; IsoId=Q9Y2Q0-3; Sequence=VSP_040977, VSP_000431; 
# AltName	AT8A1_HUMAN	ATPase class I type 8A member 1
# AltName	AT8A1_HUMAN	Chromaffin granule ATPase II
# AltName	AT8A1_HUMAN	P4-ATPase flippase complex alpha subunit ATP8A1
# BRENDA	3.6.3	2681
# BioGrid	115668	2
# CATALYTIC ACTIVITY	AT8A1_HUMAN	ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). 
# CCDS	CCDS3466	-. [Q9Y2Q0-1]
# CCDS	CCDS47049	-. [Q9Y2Q0-3]
# ChiTaRS	ATP8A1	human
# DrugBank	DB00144	Phosphatidylserine
# ENZYME REGULATION	ATPase activity is stimulated by phosphatidylserine (PS) and minimally by phosphatidylethanolamine (PE). {ECO	0000250}. 
# Ensembl	ENST00000264449	ENSP00000264449; ENSG00000124406. [Q9Y2Q0-3]
# Ensembl	ENST00000381668	ENSP00000371084; ENSG00000124406. [Q9Y2Q0-1]
# ExpressionAtlas	Q9Y2Q0	baseline and differential
# FUNCTION	AT8A1_HUMAN	Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1 TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Acts as aminophospholipid translocase at the plasma membrane in neuronal cells. 
# GO_component	GO:0000139	Golgi membrane; IEA:GOC.
# GO_component	GO:0005783	endoplasmic reticulum; IDA:UniProtKB.
# GO_component	GO:0005794	Golgi apparatus; IDA:UniProtKB.
# GO_component	GO:0005802	trans-Golgi network; IBA:GO_Central.
# GO_component	GO:0005886	plasma membrane; IDA:UniProtKB.
# GO_component	GO:0016020	membrane; IDA:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0042584	chromaffin granule membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0043231	intracellular membrane-bounded organelle; IDA:HPA.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0000287	magnesium ion binding; IEA:InterPro.
# GO_function	GO:0004012	phospholipid-translocating ATPase activity; IBA:GO_Central.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0019829	cation-transporting ATPase activity; NAS:UniProtKB.
# GO_process	GO:0007612	learning; IEA:Ensembl.
# GO_process	GO:0030335	positive regulation of cell migration; IEA:Ensembl.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0045332	phospholipid translocation; NAS:UniProtKB.
# GO_process	GO:0048194	Golgi vesicle budding; IBA:GO_Central.
# GO_process	GO:0061092	positive regulation of phospholipid translocation; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005794	Golgi apparatus
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# GOslim_process	GO:0061024	membrane organization
# Gene3D	2.70.150.10	-; 2.
# Gene3D	3.40.1110.10	-; 1.
# Gene3D	3.40.50.1000	-; 2.
# Genevisible	Q9Y2Q0	HS
# HGNC	HGNC:13531	ATP8A1
# InterPro	IPR001757	P_typ_ATPase
# InterPro	IPR006539	P-type_ATPase_IV
# InterPro	IPR008250	ATPase_P-typ_transduc_dom_A
# InterPro	IPR018303	ATPase_P-typ_P_site
# InterPro	IPR023214	HAD-like_dom
# InterPro	IPR023299	ATPase_P-typ_cyto_domN
# InterPro	IPR030342	ATP8A1
# InterPro	IPR032630	P_typ_ATPase_c
# InterPro	IPR032631	P-type_ATPase_N
# KEGG_Brite	ko01000	Enzymes
# KEGG_Brite	ko03009	 Ribosome biogenesis
# MIM	609542	gene
# Organism	AT8A1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR24092	PTHR24092
# PANTHER	PTHR24092:SF56	PTHR24092:SF56
# PROSITE	PS00154	ATPASE_E1_E2
# Pfam	PF00122	E1-E2_ATPase
# Pfam	PF16209	PhoLip_ATPase_N
# Pfam	PF16212	PhoLip_ATPase_C
# Proteomes	UP000005640	Chromosome 4
# Reactome	R-HSA-6798695	Neutrophil degranulation
# Reactome	R-HSA-936837	Ion transport by P-type ATPases
# RecName	AT8A1_HUMAN	Phospholipid-transporting ATPase IA
# RefSeq	NP_001098999	NM_001105529.1. [Q9Y2Q0-3]
# RefSeq	NP_006086	NM_006095.2. [Q9Y2Q0-1]
# RefSeq	XP_016863134	XM_017007645.1. [Q9Y2Q0-2]
# SEQUENCE CAUTION	Sequence=AAI09318.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA77248.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	AT8A1_HUMAN	Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO 0000250|UniProtKB P70704}; Multi- pass membrane protein {ECO 0000250|UniProtKB P70704}. Cytoplasmic granule {ECO 0000269|PubMed 20947505}. Cell membrane {ECO 0000269|PubMed 20947505, ECO 0000269|PubMed 21914794}. Endoplasmic reticulum {ECO 0000269|PubMed 20947505, ECO 0000269|PubMed 21914794}. Golgi apparatus {ECO 0000269|PubMed 20947505, ECO 0000269|PubMed 21914794}. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B (PubMed 20947505). In the presence of TMEM30A, predominantly located in cytoplasmic punctate structures and localizes to the plasma membrane (PubMed 20947505). Localizes to plasma membranes of red blood cells (By similarity). {ECO 0000250|UniProtKB P70704, ECO 0000269|PubMed 20947505}. 
# SUBUNIT	AT8A1_HUMAN	Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit. Interacts with TMEM30A to form a flippase complex; the interaction with TMEM30B is reported conflictingly. {ECO 0000269|PubMed 20947505, ECO 0000269|PubMed 20961850, ECO 0000269|PubMed 21914794}. 
# SUPFAM	SSF56784	SSF56784; 3
# SUPFAM	SSF81660	SSF81660
# TCDB	3.A.3.8.13	the p-type atpase (p-atpase) superfamily
# TIGRFAMs	TIGR01494	ATPase_P-type; 3
# TIGRFAMs	TIGR01652	ATPase-Plipid
# TISSUE SPECIFICITY	AT8A1_HUMAN	Found in most adult tissues except liver, testis and placenta. Most abundant in heart, brain and skeletal muscle. Also detected in fetal tissues. Isoform 1 is only detected in brain, skeletal muscle and heart and is the most abundant form in skeletal muscle. 
# UCSC	uc003gwr	human. [Q9Y2Q0-1]
# eggNOG	ENOG410ITKD	Eukaryota
# eggNOG	ENOG410XPYK	LUCA
BLAST	swissprot:AT8A1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:AT8A1_HUMAN
BioCyc	ZFISH:HS04767-MONOMER	http://biocyc.org/getid?id=ZFISH:HS04767-MONOMER
COXPRESdb	10396	http://coxpresdb.jp/data/gene/10396.shtml
CleanEx	HS_ATP8A1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP8A1
DOI	10.1006/bbrc.1999.0347	http://dx.doi.org/10.1006/bbrc.1999.0347
DOI	10.1021/pr0704130	http://dx.doi.org/10.1021/pr0704130
DOI	10.1038/nature03466	http://dx.doi.org/10.1038/nature03466
DOI	10.1074/jbc.M110.139006	http://dx.doi.org/10.1074/jbc.M110.139006
DOI	10.1074/jbc.M110.139543	http://dx.doi.org/10.1074/jbc.M110.139543
DOI	10.1074/jbc.M111.281006	http://dx.doi.org/10.1074/jbc.M111.281006
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/scisignal.2000007	http://dx.doi.org/10.1126/scisignal.2000007
DrugBank	DB00144	http://www.drugbank.ca/drugs/DB00144
EC_number	EC:3.6.3.1	http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.1
EMBL	AB013452	http://www.ebi.ac.uk/ena/data/view/AB013452
EMBL	AC084010	http://www.ebi.ac.uk/ena/data/view/AC084010
EMBL	AC096734	http://www.ebi.ac.uk/ena/data/view/AC096734
EMBL	AC110788	http://www.ebi.ac.uk/ena/data/view/AC110788
EMBL	AC139717	http://www.ebi.ac.uk/ena/data/view/AC139717
EMBL	AF067820	http://www.ebi.ac.uk/ena/data/view/AF067820
EMBL	BC109317	http://www.ebi.ac.uk/ena/data/view/BC109317
EMBL	BC109318	http://www.ebi.ac.uk/ena/data/view/BC109318
EMBL	CH471069	http://www.ebi.ac.uk/ena/data/view/CH471069
ENZYME	3.6.3.1	http://enzyme.expasy.org/EC/3.6.3.1
Ensembl	ENST00000264449	http://www.ensembl.org/id/ENST00000264449
Ensembl	ENST00000381668	http://www.ensembl.org/id/ENST00000381668
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GO_component	GO:0005802	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005802
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0042584	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042584
GO_component	GO:0043231	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0000287	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287
GO_function	GO:0004012	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004012
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0019829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019829
GO_process	GO:0007612	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007612
GO_process	GO:0030335	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030335
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0045332	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045332
GO_process	GO:0048194	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048194
GO_process	GO:0061092	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061092
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005794	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005794
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_process	GO:0061024	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024
Gene3D	2.70.150.10	http://www.cathdb.info/version/latest/superfamily/2.70.150.10
Gene3D	3.40.1110.10	http://www.cathdb.info/version/latest/superfamily/3.40.1110.10
Gene3D	3.40.50.1000	http://www.cathdb.info/version/latest/superfamily/3.40.50.1000
GeneCards	ATP8A1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP8A1
GeneID	10396	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10396
GeneTree	ENSGT00860000133712	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00860000133712
HGNC	HGNC:13531	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13531
HOGENOM	HOG000202528	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202528&db=HOGENOM6
HOVERGEN	HBG050601	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050601&db=HOVERGEN
HPA	HPA049948	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA049948
HPA	HPA052935	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA052935
InParanoid	Q9Y2Q0	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y2Q0
IntAct	Q9Y2Q0	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9Y2Q0*
IntEnz	3.6.3.1	http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.1
InterPro	IPR001757	http://www.ebi.ac.uk/interpro/entry/IPR001757
InterPro	IPR006539	http://www.ebi.ac.uk/interpro/entry/IPR006539
InterPro	IPR008250	http://www.ebi.ac.uk/interpro/entry/IPR008250
InterPro	IPR018303	http://www.ebi.ac.uk/interpro/entry/IPR018303
InterPro	IPR023214	http://www.ebi.ac.uk/interpro/entry/IPR023214
InterPro	IPR023299	http://www.ebi.ac.uk/interpro/entry/IPR023299
InterPro	IPR030342	http://www.ebi.ac.uk/interpro/entry/IPR030342
InterPro	IPR032630	http://www.ebi.ac.uk/interpro/entry/IPR032630
InterPro	IPR032631	http://www.ebi.ac.uk/interpro/entry/IPR032631
Jabion	10396	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10396
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Brite	ko03009	http://www.genome.jp/dbget-bin/www_bget?ko03009
KEGG_Gene	hsa:10396	http://www.genome.jp/dbget-bin/www_bget?hsa:10396
KEGG_Orthology	KO:K14802	http://www.genome.jp/dbget-bin/www_bget?KO:K14802
MIM	609542	http://www.ncbi.nlm.nih.gov/omim/609542
OMA	KDLDMHY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KDLDMHY
OrthoDB	EOG091G0139	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0139
PANTHER	PTHR24092	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24092
PANTHER	PTHR24092:SF56	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24092:SF56
PROSITE	PS00154	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00154
PSORT	swissprot:AT8A1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:AT8A1_HUMAN
PSORT-B	swissprot:AT8A1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:AT8A1_HUMAN
PSORT2	swissprot:AT8A1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:AT8A1_HUMAN
Pfam	PF00122	http://pfam.xfam.org/family/PF00122
Pfam	PF16209	http://pfam.xfam.org/family/PF16209
Pfam	PF16212	http://pfam.xfam.org/family/PF16212
PharmGKB	PA25165	http://www.pharmgkb.org/do/serve?objId=PA25165&objCls=Gene
Phobius	swissprot:AT8A1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:AT8A1_HUMAN
PhylomeDB	Q9Y2Q0	http://phylomedb.org/?seqid=Q9Y2Q0
ProteinModelPortal	Q9Y2Q0	http://www.proteinmodelportal.org/query/uniprot/Q9Y2Q0
PubMed	10198212	http://www.ncbi.nlm.nih.gov/pubmed/10198212
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15815621	http://www.ncbi.nlm.nih.gov/pubmed/15815621
PubMed	18088087	http://www.ncbi.nlm.nih.gov/pubmed/18088087
PubMed	19690332	http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed	20947505	http://www.ncbi.nlm.nih.gov/pubmed/20947505
PubMed	20961850	http://www.ncbi.nlm.nih.gov/pubmed/20961850
PubMed	21914794	http://www.ncbi.nlm.nih.gov/pubmed/21914794
Reactome	R-HSA-6798695	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6798695
Reactome	R-HSA-936837	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-936837
RefSeq	NP_001098999	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001098999
RefSeq	NP_006086	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_006086
RefSeq	XP_016863134	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016863134
STRING	9606.ENSP00000371084	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000371084&targetmode=cogs
SUPFAM	SSF56784	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784
SUPFAM	SSF81660	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81660
TCDB	3.A.3.8.13	http://www.tcdb.org/search/result.php?tc=3.A.3.8.13
TIGRFAMs	TIGR01494	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01494
TIGRFAMs	TIGR01652	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01652
UCSC	uc003gwr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003gwr&org=rat
UniGene	Hs.435052	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.435052
UniProtKB	AT8A1_HUMAN	http://www.uniprot.org/uniprot/AT8A1_HUMAN
UniProtKB-AC	Q9Y2Q0	http://www.uniprot.org/uniprot/Q9Y2Q0
charge	swissprot:AT8A1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:AT8A1_HUMAN
eggNOG	ENOG410ITKD	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ITKD
eggNOG	ENOG410XPYK	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPYK
epestfind	swissprot:AT8A1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:AT8A1_HUMAN
garnier	swissprot:AT8A1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:AT8A1_HUMAN
helixturnhelix	swissprot:AT8A1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:AT8A1_HUMAN
hmoment	swissprot:AT8A1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:AT8A1_HUMAN
iep	swissprot:AT8A1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:AT8A1_HUMAN
inforesidue	swissprot:AT8A1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:AT8A1_HUMAN
neXtProt	NX_Q9Y2Q0	http://www.nextprot.org/db/entry/NX_Q9Y2Q0
octanol	swissprot:AT8A1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:AT8A1_HUMAN
pepcoil	swissprot:AT8A1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:AT8A1_HUMAN
pepdigest	swissprot:AT8A1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:AT8A1_HUMAN
pepinfo	swissprot:AT8A1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:AT8A1_HUMAN
pepnet	swissprot:AT8A1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:AT8A1_HUMAN
pepstats	swissprot:AT8A1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:AT8A1_HUMAN
pepwheel	swissprot:AT8A1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:AT8A1_HUMAN
pepwindow	swissprot:AT8A1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:AT8A1_HUMAN
sigcleave	swissprot:AT8A1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:AT8A1_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	CLCN6_HUMAN	Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=A, Clc-6a; IsoId=P51797-1; Sequence=Displayed; Name=2; Synonyms=B, ClC-6b, D2-A1; IsoId=P51797-2; Sequence=VSP_001043, VSP_001044; Name=3; Synonyms=C, ClC-6c, D1-A1; IsoId=P51797-3; Sequence=VSP_001045, VSP_001046; Name=4; Synonyms=D, ClC-6d, D1-A2; IsoId=P51797-4; Sequence=VSP_001047, VSP_001048; Name=5; IsoId=P51797-5; Sequence=VSP_017188; Note=No experimental confirmation available.; Name=6; IsoId=P51797-6; Sequence=VSP_047169; Note=No experimental confirmation available.; 
# AltName	CLCN6_HUMAN	Chloride channel protein 6
# BioGrid	107599	4
# CCDS	CCDS138	-. [P51797-1]
# CCDS	CCDS57972	-. [P51797-6]
# ChiTaRS	CLCN6	human
# Ensembl	ENST00000312413	ENSP00000308367; ENSG00000011021. [P51797-6]
# Ensembl	ENST00000346436	ENSP00000234488; ENSG00000011021. [P51797-1]
# Ensembl	ENST00000376496	ENSP00000365679; ENSG00000011021. [P51797-5]
# ExpressionAtlas	P51797	baseline and differential
# FUNCTION	CLCN6_HUMAN	Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter. 
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0010008	endosome membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; NAS:UniProtKB.
# GO_function	GO:0005247	voltage-gated chloride channel activity; NAS:UniProtKB.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0015297	antiporter activity; TAS:Reactome.
# GO_function	GO:0031404	chloride ion binding; IBA:GO_Central.
# GO_process	GO:0006821	chloride transport; NAS:UniProtKB.
# GO_process	GO:0006884	cell volume homeostasis; NAS:UniProtKB.
# GO_process	GO:0007165	signal transduction; NAS:UniProtKB.
# GO_process	GO:0009612	response to mechanical stimulus; IEA:Ensembl.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:1902476	chloride transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.10.3080.10	-; 2.
# Genevisible	P51797	HS
# HGNC	HGNC:2024	CLCN6
# InterPro	IPR000644	CBS_dom
# InterPro	IPR001807	Cl-channel_volt-gated
# InterPro	IPR002248	Cl_channel-6
# InterPro	IPR014743	Cl-channel_core
# KEGG_Brite	ko04040	Ion channels
# MIM	602726	gene
# MISCELLANEOUS	The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {ECO	0000250}. 
# Organism	CLCN6_HUMAN	Homo sapiens (Human)
# PIR	S68428	S68428
# PRINTS	PR00762	CLCHANNEL
# PRINTS	PR01117	CLCHANNEL6
# PROSITE	PS51371	CBS; 2
# PTM	CLCN6_HUMAN	N-glycosylated on several asparagine residues. {ECO 0000269|PubMed 17534424}. 
# Pfam	PF00571	CBS; 2
# Pfam	PF00654	Voltage_CLC
# Proteomes	UP000005640	Chromosome 1
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# Reactome	R-HSA-6802952	Signaling by BRAF and RAF fusions
# RecName	CLCN6_HUMAN	Chloride transport protein 6
# RefSeq	NP_001243888	NM_001256959.1
# RefSeq	NP_001277	NM_001286.3
# SIMILARITY	Belongs to the chloride channel (TC 2.A.49) family. ClC-6/CLCN6 subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 2 CBS domains. {ECO:0000255|PROSITE- ProRule	PRU00703}.
# SMART	SM00116	CBS; 2
# SUBCELLULAR LOCATION	CLCN6_HUMAN	Endosome membrane {ECO 0000269|PubMed 17534424}; Multi-pass membrane protein {ECO 0000269|PubMed 17534424}. Note=Detected in detergent- resistant lipid rafts. 
# SUPFAM	SSF81340	SSF81340; 2
# TISSUE SPECIFICITY	CLCN6_HUMAN	Testis, ovary, small intestine, brain and skeletal muscle. Low level expression in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Isoform 3 is only detected in kidney. {ECO 0000269|PubMed 10198195, ECO 0000269|PubMed 8543009, ECO 0000269|PubMed 9224655}. 
# UCSC	uc001ate	human. [P51797-1]
# eggNOG	COG0038	LUCA
# eggNOG	KOG0474	Eukaryota
BLAST	swissprot:CLCN6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CLCN6_HUMAN
BioCyc	ZFISH:ENSG00000011021-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000011021-MONOMER
COXPRESdb	1185	http://coxpresdb.jp/data/gene/1185.shtml
DOI	10.1006/jmcc.1998.0901	http://dx.doi.org/10.1006/jmcc.1998.0901
DOI	10.1016/0014-5793(95)01298-2	http://dx.doi.org/10.1016/0014-5793(95)01298-2
DOI	10.1016/S0167-4781(99)00128-1	http://dx.doi.org/10.1016/S0167-4781(99)00128-1
DOI	10.1038/nature04727	http://dx.doi.org/10.1038/nature04727
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/bj3250269	http://dx.doi.org/10.1042/bj3250269
DOI	10.1093/dnares/1.5.223	http://dx.doi.org/10.1093/dnares/1.5.223
DOI	10.1093/dnares/9.3.99	http://dx.doi.org/10.1093/dnares/9.3.99
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1371/journal.pone.0000474	http://dx.doi.org/10.1371/journal.pone.0000474
EMBL	AF009247	http://www.ebi.ac.uk/ena/data/view/AF009247
EMBL	AF009248	http://www.ebi.ac.uk/ena/data/view/AF009248
EMBL	AF009249	http://www.ebi.ac.uk/ena/data/view/AF009249
EMBL	AF009250	http://www.ebi.ac.uk/ena/data/view/AF009250
EMBL	AF009251	http://www.ebi.ac.uk/ena/data/view/AF009251
EMBL	AF009252	http://www.ebi.ac.uk/ena/data/view/AF009252
EMBL	AF009253	http://www.ebi.ac.uk/ena/data/view/AF009253
EMBL	AF009254	http://www.ebi.ac.uk/ena/data/view/AF009254
EMBL	AF009255	http://www.ebi.ac.uk/ena/data/view/AF009255
EMBL	AF009256	http://www.ebi.ac.uk/ena/data/view/AF009256
EMBL	AF009257	http://www.ebi.ac.uk/ena/data/view/AF009257
EMBL	AK289999	http://www.ebi.ac.uk/ena/data/view/AK289999
EMBL	AK294764	http://www.ebi.ac.uk/ena/data/view/AK294764
EMBL	AL021155	http://www.ebi.ac.uk/ena/data/view/AL021155
EMBL	AL021155	http://www.ebi.ac.uk/ena/data/view/AL021155
EMBL	AL021155	http://www.ebi.ac.uk/ena/data/view/AL021155
EMBL	AL021155	http://www.ebi.ac.uk/ena/data/view/AL021155
EMBL	AL021155	http://www.ebi.ac.uk/ena/data/view/AL021155
EMBL	AL021155	http://www.ebi.ac.uk/ena/data/view/AL021155
EMBL	AL021155	http://www.ebi.ac.uk/ena/data/view/AL021155
EMBL	AL021155	http://www.ebi.ac.uk/ena/data/view/AL021155
EMBL	AL021155	http://www.ebi.ac.uk/ena/data/view/AL021155
EMBL	AL021155	http://www.ebi.ac.uk/ena/data/view/AL021155
EMBL	AL953897	http://www.ebi.ac.uk/ena/data/view/AL953897
EMBL	AL953897	http://www.ebi.ac.uk/ena/data/view/AL953897
EMBL	AL953897	http://www.ebi.ac.uk/ena/data/view/AL953897
EMBL	AL953897	http://www.ebi.ac.uk/ena/data/view/AL953897
EMBL	AL953897	http://www.ebi.ac.uk/ena/data/view/AL953897
EMBL	AL953897	http://www.ebi.ac.uk/ena/data/view/AL953897
EMBL	AL953897	http://www.ebi.ac.uk/ena/data/view/AL953897
EMBL	AL953897	http://www.ebi.ac.uk/ena/data/view/AL953897
EMBL	AL953897	http://www.ebi.ac.uk/ena/data/view/AL953897
EMBL	AL953897	http://www.ebi.ac.uk/ena/data/view/AL953897
EMBL	BC117420	http://www.ebi.ac.uk/ena/data/view/BC117420
EMBL	BC117424	http://www.ebi.ac.uk/ena/data/view/BC117424
EMBL	CH471130	http://www.ebi.ac.uk/ena/data/view/CH471130
EMBL	D28475	http://www.ebi.ac.uk/ena/data/view/D28475
EMBL	X83378	http://www.ebi.ac.uk/ena/data/view/X83378
EMBL	X96391	http://www.ebi.ac.uk/ena/data/view/X96391
EMBL	X99472	http://www.ebi.ac.uk/ena/data/view/X99472
EMBL	X99473	http://www.ebi.ac.uk/ena/data/view/X99473
EMBL	X99474	http://www.ebi.ac.uk/ena/data/view/X99474
EMBL	X99475	http://www.ebi.ac.uk/ena/data/view/X99475
Ensembl	ENST00000312413	http://www.ensembl.org/id/ENST00000312413
Ensembl	ENST00000346436	http://www.ensembl.org/id/ENST00000346436
Ensembl	ENST00000376496	http://www.ensembl.org/id/ENST00000376496
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0010008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010008
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005247	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005247
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0015297	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297
GO_function	GO:0031404	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031404
GO_process	GO:0006821	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006821
GO_process	GO:0006884	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006884
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0009612	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009612
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:1902476	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.10.3080.10	http://www.cathdb.info/version/latest/superfamily/1.10.3080.10
GeneCards	CLCN6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CLCN6
GeneID	1185	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1185
GeneTree	ENSGT00760000119109	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119109
HGNC	HGNC:2024	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:2024
HOVERGEN	HBG050985	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050985&db=HOVERGEN
HPA	HPA032097	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA032097
InParanoid	P51797	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P51797
IntAct	P51797	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P51797*
InterPro	IPR000644	http://www.ebi.ac.uk/interpro/entry/IPR000644
InterPro	IPR001807	http://www.ebi.ac.uk/interpro/entry/IPR001807
InterPro	IPR002248	http://www.ebi.ac.uk/interpro/entry/IPR002248
InterPro	IPR014743	http://www.ebi.ac.uk/interpro/entry/IPR014743
Jabion	1185	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=1185
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:1185	http://www.genome.jp/dbget-bin/www_bget?hsa:1185
KEGG_Orthology	KO:K05015	http://www.genome.jp/dbget-bin/www_bget?KO:K05015
MIM	602726	http://www.ncbi.nlm.nih.gov/omim/602726
OMA	ESMDNKK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ESMDNKK
OrthoDB	EOG091G01HL	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G01HL
PRINTS	PR00762	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00762
PRINTS	PR01117	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01117
PROSITE	PS51371	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51371
PSORT	swissprot:CLCN6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CLCN6_HUMAN
PSORT-B	swissprot:CLCN6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CLCN6_HUMAN
PSORT2	swissprot:CLCN6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CLCN6_HUMAN
Pfam	PF00571	http://pfam.xfam.org/family/PF00571
Pfam	PF00654	http://pfam.xfam.org/family/PF00654
PharmGKB	PA26551	http://www.pharmgkb.org/do/serve?objId=PA26551&objCls=Gene
Phobius	swissprot:CLCN6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CLCN6_HUMAN
PhylomeDB	P51797	http://phylomedb.org/?seqid=P51797
ProteinModelPortal	P51797	http://www.proteinmodelportal.org/query/uniprot/P51797
PubMed	10198195	http://www.ncbi.nlm.nih.gov/pubmed/10198195
PubMed	10500249	http://www.ncbi.nlm.nih.gov/pubmed/10500249
PubMed	12168954	http://www.ncbi.nlm.nih.gov/pubmed/12168954
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16710414	http://www.ncbi.nlm.nih.gov/pubmed/16710414
PubMed	17534424	http://www.ncbi.nlm.nih.gov/pubmed/17534424
PubMed	7584044	http://www.ncbi.nlm.nih.gov/pubmed/7584044
PubMed	8543009	http://www.ncbi.nlm.nih.gov/pubmed/8543009
PubMed	9224655	http://www.ncbi.nlm.nih.gov/pubmed/9224655
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
Reactome	R-HSA-6802952	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6802952
RefSeq	NP_001243888	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243888
RefSeq	NP_001277	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001277
SMART	SM00116	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00116
STRING	9606.ENSP00000234488	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000234488&targetmode=cogs
SUPFAM	SSF81340	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81340
UCSC	uc001ate	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001ate&org=rat
UniGene	Hs.193043	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.193043
UniProtKB	CLCN6_HUMAN	http://www.uniprot.org/uniprot/CLCN6_HUMAN
UniProtKB-AC	P51797	http://www.uniprot.org/uniprot/P51797
charge	swissprot:CLCN6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CLCN6_HUMAN
eggNOG	COG0038	http://eggnogapi.embl.de/nog_data/html/tree/COG0038
eggNOG	KOG0474	http://eggnogapi.embl.de/nog_data/html/tree/KOG0474
epestfind	swissprot:CLCN6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CLCN6_HUMAN
garnier	swissprot:CLCN6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CLCN6_HUMAN
helixturnhelix	swissprot:CLCN6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLCN6_HUMAN
hmoment	swissprot:CLCN6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CLCN6_HUMAN
iep	swissprot:CLCN6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CLCN6_HUMAN
inforesidue	swissprot:CLCN6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CLCN6_HUMAN
neXtProt	NX_P51797	http://www.nextprot.org/db/entry/NX_P51797
octanol	swissprot:CLCN6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CLCN6_HUMAN
pepcoil	swissprot:CLCN6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CLCN6_HUMAN
pepdigest	swissprot:CLCN6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CLCN6_HUMAN
pepinfo	swissprot:CLCN6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CLCN6_HUMAN
pepnet	swissprot:CLCN6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CLCN6_HUMAN
pepstats	swissprot:CLCN6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CLCN6_HUMAN
pepwheel	swissprot:CLCN6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CLCN6_HUMAN
pepwindow	swissprot:CLCN6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CLCN6_HUMAN
sigcleave	swissprot:CLCN6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CLCN6_HUMAN
## Database	ID	URL or Descriptions
# AltName	ORNT1_HUMAN	Solute carrier family 25 member 15
# BioGrid	115468	14
# ChiTaRS	SLC25A15	human
# DISEASE	ORNT1_HUMAN	Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome (HHH syndrome) [MIM 238970]  Autosomal recessive disorder resulting in various neurologic symptoms, including mental retardation, spastic paraparesis with pyramidal signs, cerebellar ataxia, and episodic disturbance of consciousness or coma caused by hyperammonemia. It causes a functional impairment of the urea cycle. {ECO 0000269|PubMed 10369256, ECO 0000269|PubMed 10805333, ECO 0000269|PubMed 11552031, ECO 0000269|PubMed 11668643, ECO 0000269|PubMed 11814739, ECO 0000269|PubMed 16601889, ECO 0000269|PubMed 19242930}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00129	L-Ornithine
# Ensembl	ENST00000338625	ENSP00000342267; ENSG00000102743
# ExpressionAtlas	Q9Y619	baseline and differential
# FUNCTION	ORNT1_HUMAN	Ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix. 
# GO_component	GO:0005743	mitochondrial inner membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_function	GO:0000064	L-ornithine transmembrane transporter activity; EXP:Reactome.
# GO_process	GO:0000050	urea cycle; TAS:Reactome.
# GO_process	GO:0000066	mitochondrial ornithine transport; TAS:ProtInc.
# GO_process	GO:0006520	cellular amino acid metabolic process; TAS:ProtInc.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006520	cellular amino acid metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0009058	biosynthetic process
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0044281	small molecule metabolic process
# GOslim_process	GO:0071941	nitrogen cycle metabolic process
# Gene3D	1.50.40.10	-; 1.
# Genevisible	Q9Y619	HS
# HGNC	HGNC:10985	SLC25A15
# InterPro	IPR018108	Mitochondrial_sb/sol_carrier
# InterPro	IPR023395	Mt_carrier_dom
# KEGG_Brite	ko02001	Solute carrier family
# KEGG_Disease	H01268	[Inherited metabolic disease] HHH syndrome
# KEGG_Disease	H01398:[Inherited metabolic disease] Citrullinemia type II  [DS	H00185]
# MIM	238970	phenotype
# MIM	603861	gene
# Organism	ORNT1_HUMAN	Homo sapiens (Human)
# Orphanet	415	Hyperornithinemia-hyperammonemia-homocitrullinuria
# PROSITE	PS50920	SOLCAR; 3
# Pfam	PF00153	Mito_carr; 3
# Proteomes	UP000005640	Chromosome 13
# Reactome	R-HSA-70635	Urea cycle
# RecName	ORNT1_HUMAN	Mitochondrial ornithine transporter 1
# RefSeq	NP_055067	NM_014252.3
# SIMILARITY	Belongs to the mitochondrial carrier (TC 2.A.29) family. {ECO	0000305}. 
# SIMILARITY	Contains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule	PRU00282}.
# SUBCELLULAR LOCATION	ORNT1_HUMAN	Mitochondrion inner membrane; Multi-pass membrane protein. 
# SUPFAM	SSF103506	SSF103506
# TCDB	2.A.29.19	the mitochondrial carrier (mc) family
# UCSC	uc001uxn	human
# eggNOG	ENOG410XNVH	LUCA
# eggNOG	KOG0763	Eukaryota
BLAST	swissprot:ORNT1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ORNT1_HUMAN
BioCyc	ZFISH:ENSG00000102743-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000102743-MONOMER
COXPRESdb	10166	http://coxpresdb.jp/data/gene/10166.shtml
CleanEx	HS_SLC25A15	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC25A15
DOI	10.1002/1531-8249(200005)47:5<625::AID-ANA10>3.3.CO	http://dx.doi.org/10.1002/1531-8249(200005)47:5<625::AID-ANA10>3.3.CO
DOI	10.1002/humu.1221	http://dx.doi.org/10.1002/humu.1221
DOI	10.1002/humu.20930	http://dx.doi.org/10.1002/humu.20930
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1007/s10545-006-0120-7	http://dx.doi.org/10.1007/s10545-006-0120-7
DOI	10.1016/S0887-8994(01)00335-6	http://dx.doi.org/10.1016/S0887-8994(01)00335-6
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1038/9658	http://dx.doi.org/10.1038/9658
DOI	10.1038/nature02379	http://dx.doi.org/10.1038/nature02379
DOI	10.1073/pnas.0404089101	http://dx.doi.org/10.1073/pnas.0404089101
DOI	10.1074/jbc.M302317200	http://dx.doi.org/10.1074/jbc.M302317200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1212/WNL.57.5.911	http://dx.doi.org/10.1212/WNL.57.5.911
DrugBank	DB00129	http://www.drugbank.ca/drugs/DB00129
EMBL	AF112968	http://www.ebi.ac.uk/ena/data/view/AF112968
EMBL	AF177333	http://www.ebi.ac.uk/ena/data/view/AF177333
EMBL	AJ309943	http://www.ebi.ac.uk/ena/data/view/AJ309943
EMBL	AL161614	http://www.ebi.ac.uk/ena/data/view/AL161614
EMBL	BC002702	http://www.ebi.ac.uk/ena/data/view/BC002702
EMBL	CH471075	http://www.ebi.ac.uk/ena/data/view/CH471075
Ensembl	ENST00000338625	http://www.ensembl.org/id/ENST00000338625
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0000064	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000064
GO_process	GO:0000050	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000050
GO_process	GO:0000066	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000066
GO_process	GO:0006520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006520	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0044281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_process	GO:0071941	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941
Gene3D	1.50.40.10	http://www.cathdb.info/version/latest/superfamily/1.50.40.10
GeneCards	SLC25A15	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC25A15
GeneID	10166	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10166
GeneTree	ENSGT00730000110966	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00730000110966
H-InvDB	HIX0011260	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0011260
HGNC	HGNC:10985	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10985
HOGENOM	HOG000168307	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000168307&db=HOGENOM6
HOVERGEN	HBG062630	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG062630&db=HOVERGEN
HPA	HPA042146	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA042146
InParanoid	Q9Y619	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9Y619
InterPro	IPR018108	http://www.ebi.ac.uk/interpro/entry/IPR018108
InterPro	IPR023395	http://www.ebi.ac.uk/interpro/entry/IPR023395
Jabion	10166	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10166
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Disease	H01268	http://www.genome.jp/dbget-bin/www_bget?H01268
KEGG_Disease	H01398	http://www.genome.jp/dbget-bin/www_bget?H01398
KEGG_Gene	hsa:10166	http://www.genome.jp/dbget-bin/www_bget?hsa:10166
KEGG_Orthology	KO:K15101	http://www.genome.jp/dbget-bin/www_bget?KO:K15101
MIM	238970	http://www.ncbi.nlm.nih.gov/omim/238970
MIM	603861	http://www.ncbi.nlm.nih.gov/omim/603861
OMA	DMYKGIV	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DMYKGIV
Orphanet	415	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=415
OrthoDB	EOG091G0HVE	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0HVE
PROSITE	PS50920	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50920
PSORT	swissprot:ORNT1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ORNT1_HUMAN
PSORT-B	swissprot:ORNT1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ORNT1_HUMAN
PSORT2	swissprot:ORNT1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ORNT1_HUMAN
Pfam	PF00153	http://pfam.xfam.org/family/PF00153
PharmGKB	PA35861	http://www.pharmgkb.org/do/serve?objId=PA35861&objCls=Gene
Phobius	swissprot:ORNT1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ORNT1_HUMAN
PhylomeDB	Q9Y619	http://phylomedb.org/?seqid=Q9Y619
ProteinModelPortal	Q9Y619	http://www.proteinmodelportal.org/query/uniprot/Q9Y619
PubMed	10369256	http://www.ncbi.nlm.nih.gov/pubmed/10369256
PubMed	10805333	http://www.ncbi.nlm.nih.gov/pubmed/10805333
PubMed	11552031	http://www.ncbi.nlm.nih.gov/pubmed/11552031
PubMed	11668643	http://www.ncbi.nlm.nih.gov/pubmed/11668643
PubMed	11814739	http://www.ncbi.nlm.nih.gov/pubmed/11814739
PubMed	12807890	http://www.ncbi.nlm.nih.gov/pubmed/12807890
PubMed	15057823	http://www.ncbi.nlm.nih.gov/pubmed/15057823
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15498874	http://www.ncbi.nlm.nih.gov/pubmed/15498874
PubMed	16601889	http://www.ncbi.nlm.nih.gov/pubmed/16601889
PubMed	19242930	http://www.ncbi.nlm.nih.gov/pubmed/19242930
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
Reactome	R-HSA-70635	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-70635
RefSeq	NP_055067	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055067
STRING	9606.ENSP00000342267	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000342267&targetmode=cogs
SUPFAM	SSF103506	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103506
TCDB	2.A.29.19	http://www.tcdb.org/search/result.php?tc=2.A.29.19
UCSC	uc001uxn	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001uxn&org=rat
UniGene	Hs.646645	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.646645
UniProtKB	ORNT1_HUMAN	http://www.uniprot.org/uniprot/ORNT1_HUMAN
UniProtKB-AC	Q9Y619	http://www.uniprot.org/uniprot/Q9Y619
charge	swissprot:ORNT1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ORNT1_HUMAN
eggNOG	ENOG410XNVH	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNVH
eggNOG	KOG0763	http://eggnogapi.embl.de/nog_data/html/tree/KOG0763
epestfind	swissprot:ORNT1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ORNT1_HUMAN
garnier	swissprot:ORNT1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ORNT1_HUMAN
helixturnhelix	swissprot:ORNT1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ORNT1_HUMAN
hmoment	swissprot:ORNT1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ORNT1_HUMAN
iep	swissprot:ORNT1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ORNT1_HUMAN
inforesidue	swissprot:ORNT1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ORNT1_HUMAN
neXtProt	NX_Q9Y619	http://www.nextprot.org/db/entry/NX_Q9Y619
octanol	swissprot:ORNT1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ORNT1_HUMAN
pepcoil	swissprot:ORNT1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ORNT1_HUMAN
pepdigest	swissprot:ORNT1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ORNT1_HUMAN
pepinfo	swissprot:ORNT1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ORNT1_HUMAN
pepnet	swissprot:ORNT1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ORNT1_HUMAN
pepstats	swissprot:ORNT1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ORNT1_HUMAN
pepwheel	swissprot:ORNT1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ORNT1_HUMAN
pepwindow	swissprot:ORNT1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ORNT1_HUMAN
sigcleave	swissprot:ORNT1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ORNT1_HUMAN
## Database	ID	URL or Descriptions
# AltName	S35A5_HUMAN	Solute carrier family 35 member A5
# BioGrid	120361	8
# ChiTaRS	SLC35A5	human
# Ensembl	ENST00000492406	ENSP00000417654; ENSG00000138459
# ExpressionAtlas	Q9BS91	baseline and differential
# GO_component	GO:0000139	Golgi membrane; IEA:InterPro.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	S35A5_HUMAN	GO 0005351 sugar proton symporter activity; IEA InterPro.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# Genevisible	Q9BS91	HS
# HGNC	HGNC:20792	SLC35A5
# InterPro	IPR007271	Nuc_sug_transpt
# KEGG_Brite	ko02001	Solute carrier family
# Organism	S35A5_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10231	PTHR10231; 2
# PIRSF	PIRSF005799	UDP-gal_transpt
# Pfam	PF04142	Nuc_sug_transp
# Proteomes	UP000005640	Chromosome 3
# RecName	S35A5_HUMAN	Probable UDP-sugar transporter protein SLC35A5
# RefSeq	NP_060415	NM_017945.3
# RefSeq	XP_011511250	XM_011512948.1
# SEQUENCE CAUTION	Sequence=BAD18792.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the nucleotide-sugar transporter family. SLC35A subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	S35A5_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# TCDB	2.A.7.12.14	the drug/metabolite transporter (dmt) superfamily
# UCSC	uc003dze	human
# eggNOG	COG0697	LUCA
# eggNOG	KOG2234	Eukaryota
BLAST	swissprot:S35A5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:S35A5_HUMAN
COXPRESdb	55032	http://coxpresdb.jp/data/gene/55032.shtml
CleanEx	HS_SLC35A5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC35A5
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1101/gr.1293003	http://dx.doi.org/10.1101/gr.1293003
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AK000737	http://www.ebi.ac.uk/ena/data/view/AK000737
EMBL	AK172825	http://www.ebi.ac.uk/ena/data/view/AK172825
EMBL	AL117531	http://www.ebi.ac.uk/ena/data/view/AL117531
EMBL	AY358994	http://www.ebi.ac.uk/ena/data/view/AY358994
EMBL	BC005207	http://www.ebi.ac.uk/ena/data/view/BC005207
EMBL	BC010307	http://www.ebi.ac.uk/ena/data/view/BC010307
EMBL	BC013046	http://www.ebi.ac.uk/ena/data/view/BC013046
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
EMBL	CH471052	http://www.ebi.ac.uk/ena/data/view/CH471052
Ensembl	ENST00000492406	http://www.ensembl.org/id/ENST00000492406
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005351	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005351
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GeneCards	SLC35A5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC35A5
GeneID	55032	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55032
GeneTree	ENSGT00550000074563	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074563
HGNC	HGNC:20792	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:20792
HOGENOM	HOG000154236	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000154236&db=HOGENOM6
HOVERGEN	HBG056977	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG056977&db=HOVERGEN
HPA	HPA035519	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA035519
HPA	HPA057964	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA057964
InParanoid	Q9BS91	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9BS91
InterPro	IPR007271	http://www.ebi.ac.uk/interpro/entry/IPR007271
Jabion	55032	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=55032
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:55032	http://www.genome.jp/dbget-bin/www_bget?hsa:55032
KEGG_Orthology	KO:K15274	http://www.genome.jp/dbget-bin/www_bget?KO:K15274
OMA	LFRSECP	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LFRSECP
OrthoDB	EOG091G08HH	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08HH
PANTHER	PTHR10231	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10231
PSORT	swissprot:S35A5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:S35A5_HUMAN
PSORT-B	swissprot:S35A5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:S35A5_HUMAN
PSORT2	swissprot:S35A5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:S35A5_HUMAN
Pfam	PF04142	http://pfam.xfam.org/family/PF04142
PharmGKB	PA134947136	http://www.pharmgkb.org/do/serve?objId=PA134947136&objCls=Gene
Phobius	swissprot:S35A5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:S35A5_HUMAN
PhylomeDB	Q9BS91	http://phylomedb.org/?seqid=Q9BS91
ProteinModelPortal	Q9BS91	http://www.proteinmodelportal.org/query/uniprot/Q9BS91
PubMed	12975309	http://www.ncbi.nlm.nih.gov/pubmed/12975309
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
RefSeq	NP_060415	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_060415
RefSeq	XP_011511250	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011511250
STRING	9606.ENSP00000417654	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000417654&targetmode=cogs
TCDB	2.A.7.12.14	http://www.tcdb.org/search/result.php?tc=2.A.7.12.14
UCSC	uc003dze	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003dze&org=rat
UniGene	Hs.237480	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.237480
UniProtKB	S35A5_HUMAN	http://www.uniprot.org/uniprot/S35A5_HUMAN
UniProtKB-AC	Q9BS91	http://www.uniprot.org/uniprot/Q9BS91
charge	swissprot:S35A5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:S35A5_HUMAN
eggNOG	COG0697	http://eggnogapi.embl.de/nog_data/html/tree/COG0697
eggNOG	KOG2234	http://eggnogapi.embl.de/nog_data/html/tree/KOG2234
epestfind	swissprot:S35A5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:S35A5_HUMAN
garnier	swissprot:S35A5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:S35A5_HUMAN
helixturnhelix	swissprot:S35A5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:S35A5_HUMAN
hmoment	swissprot:S35A5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:S35A5_HUMAN
iep	swissprot:S35A5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:S35A5_HUMAN
inforesidue	swissprot:S35A5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:S35A5_HUMAN
neXtProt	NX_Q9BS91	http://www.nextprot.org/db/entry/NX_Q9BS91
octanol	swissprot:S35A5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:S35A5_HUMAN
pepcoil	swissprot:S35A5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:S35A5_HUMAN
pepdigest	swissprot:S35A5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:S35A5_HUMAN
pepinfo	swissprot:S35A5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:S35A5_HUMAN
pepnet	swissprot:S35A5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:S35A5_HUMAN
pepstats	swissprot:S35A5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:S35A5_HUMAN
pepwheel	swissprot:S35A5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:S35A5_HUMAN
pepwindow	swissprot:S35A5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:S35A5_HUMAN
sigcleave	swissprot:S35A5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:S35A5_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SCNNB_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P51168-1; Sequence=Displayed; Name=2; IsoId=P51168-2; Sequence=VSP_007724; 
# AltName	SCNNB_HUMAN	Beta-NaCH
# AltName	SCNNB_HUMAN	Epithelial Na(+) channel subunit beta
# AltName	SCNNB_HUMAN	Nonvoltage-gated sodium channel 1 subunit beta
# AltName	SCNNB_HUMAN	SCNEB
# BioGrid	112242	18
# CCDS	CCDS10609	-. [P51168-1]
# DISEASE	SCNNB_HUMAN	Bronchiectasis with or without elevated sweat chloride 1 (BESC1) [MIM 211400]  A debilitating respiratory disease characterized by chronic, abnormal dilatation of the bronchi and other cystic fibrosis-like symptoms in the absence of known causes of bronchiectasis (cystic fibrosis, autoimmune diseases, ciliary dyskinesia, common variable immunodeficiency, foreign body obstruction). Clinical features include sub-normal lung function, sinopulmonary infections, chronic productive cough, excessive sputum production, and elevated sweat chloride in some cases. {ECO 0000269|PubMed 16207733, ECO 0000269|PubMed 18507830, ECO 0000269|PubMed 19017867}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCNNB_HUMAN	Liddle syndrome (LIDLS) [MIM 177200]  An autosomal dominant disorder characterized by hypertension, hypokalemic alkalosis, and suppression of plasma renin activity and aldosterone secretion. {ECO 0000269|PubMed 15483078, ECO 0000269|PubMed 7550319, ECO 0000269|PubMed 8524790, ECO 0000269|PubMed 8601645, ECO 0000269|PubMed 9626162, ECO 0000269|PubMed 9794716}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCNNB_HUMAN	Pseudohypoaldosteronism 1, autosomal recessive (PHA1B) [MIM 264350]  A rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. PHA1B is a severe form involving multiple organ systems, and characterized by an often fulminant presentation in the neonatal period with dehydration, hyponatremia, hyperkalemia, metabolic acidosis, failure to thrive and weight loss. {ECO 0000269|PubMed 8589714}. Note=The disease is caused by mutations affecting the gene represented in this entry. The degree of channel function impairment differentially affects the renin-aldosterone system and urinary Na/K ratios, resulting in distinct genotype-phenotype relationships in PHA1 patients. Loss-of-function mutations are associated with a severe clinical course and age-dependent hyperactivation of the renin-aldosterone system. This feature is not observed in patients with missense mutations that reduce but do not eliminate channel function. Markedly reduced channel activity results in impaired linear growth and delayed puberty (PubMed 18634878). {ECO 0000269|PubMed 18634878}. 
# DrugBank	DB00384	Triamterene
# DrugBank	DB00594	Amiloride
# ENZYME REGULATION	Activated by WNK1, WNK2, WNK3 and WNK4. {ECO:0000250|UniProtKB	Q9WU38}. 
# Ensembl	ENST00000307331	ENSP00000302874; ENSG00000168447. [P51168-2]
# Ensembl	ENST00000343070	ENSP00000345751; ENSG00000168447. [P51168-1]
# ExpressionAtlas	P51168	baseline and differential
# FUNCTION	SCNNB_HUMAN	Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. {ECO 0000269|PubMed 7762608, ECO 0000303|PubMed 7490094}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; IDA:UniProtKB.
# GO_component	GO:0009897	external side of plasma membrane; IEA:Ensembl.
# GO_component	GO:0016324	apical plasma membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0030659	cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0034706	sodium channel complex; IDA:UniProtKB.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0015280	ligand-gated sodium channel activity; TAS:ProtInc.
# GO_function	GO:0050699	WW domain binding; IPI:BHF-UCL.
# GO_process	GO:0006814	sodium ion transport; TAS:ProtInc.
# GO_process	GO:0007588	excretion; TAS:ProtInc.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0035725	sodium ion transmembrane transport; IDA:UniProtKB.
# GO_process	GO:0050891	multicellular organismal water homeostasis; IDA:UniProtKB.
# GO_process	GO:0050896	response to stimulus; IEA:UniProtKB-KW.
# GO_process	GO:0050909	sensory perception of taste; IEA:UniProtKB-KW.
# GO_process	GO:0055078	sodium ion homeostasis; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	P51168	HS
# HGNC	HGNC:10600	SCNN1B
# INTERACTION	SCNNB_HUMAN	P46934 NEDD4; NbExp=4; IntAct=EBI-2547187, EBI-726944; 
# IntAct	P51168	4
# InterPro	IPR001873	Na+channel_ASC
# InterPro	IPR004724	ENaC
# InterPro	IPR020903	Na+channel_ASC_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H00242	[Endocrine disease; Urinary system disease] Liddle syndrome
# KEGG_Disease	H00243	[Endocrine disease; Urinary system disease] Pseudohypoaldosteronism type II (Gordon's syndrome)
# KEGG_Disease	H00892	[Respiratory disease] Bronchiectasis with or without elevated sweat chloride
# KEGG_Disease	H01633	[Cardiovascular diseases] Hypertension
# KEGG_Pathway	ko04742	Taste transduction
# KEGG_Pathway	ko04960	Aldosterone-regulated sodium reabsorption
# MIM	177200	phenotype
# MIM	211400	phenotype
# MIM	264350	phenotype
# MIM	600760	gene
# Organism	SCNNB_HUMAN	Homo sapiens (Human)
# Orphanet	171876	Generalized pseudohypoaldosteronism type 1
# Orphanet	526	Liddle syndrome
# Orphanet	60033	Idiopathic bronchiectasis
# PANTHER	PTHR11690	PTHR11690; 2
# PIR	I51915	I51915
# PRINTS	PR01078	AMINACHANNEL
# PROSITE	PS01206	ASC
# PTM	SCNNB_HUMAN	N-glycosylated. N-glycosylation is required for interaction with BPIFA1. {ECO 0000269|PubMed 24124190, ECO 0000269|PubMed 7762608}. 
# PTM	SCNNB_HUMAN	Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation. {ECO 0000250|UniProtKB P37090}. 
# Pfam	PF00858	ASC
# Proteomes	UP000005640	Chromosome 16
# Reactome	R-HSA-2672351	Stimuli-sensing channels
# RecName	SCNNB_HUMAN	Amiloride-sensitive sodium channel subunit beta
# RefSeq	NP_000327	NM_000336.2. [P51168-1]
# SIMILARITY	Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1B subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	SCNNB_HUMAN	Apical cell membrane {ECO 0000305|PubMed 7490094}; Multi-pass membrane protein {ECO 0000250|UniProtKB P37089}. Cytoplasmic vesicle membrane {ECO 0000250|UniProtKB P37090}. Note=Apical membrane of epithelial cells. {ECO 0000305|PubMed 7490094}. 
# SUBUNIT	SCNNB_HUMAN	Heterotrimer containing an alpha/SCNN1A, a beta/SCNN1B and a gamma/SCNN1G subunit. An additional delta/SCNN1D subunit exists only in some organisms and can replace the alpha/SCNN1A subunit to form an alternative channel with specific properties (PubMed 7499195, PubMed 16423824). Interacts with NEDD4 (via WW domains) (PubMed 11244092, PubMed 12167593). Interacts with NEDD4L (via WW domains) (PubMed 11244092). Interacts with WWP1 (via WW domains) (PubMed 9169421). Interacts with WWP2 (via WW domains) (PubMed 9169421, PubMed 12167593). Interacts with the full length immature form of PCSK9 (pro-PCSK9) (PubMed 22493497). Interacts (N-glycosylated) with BPIFA1; the interaction is direct and inhibits the proteolytic processing of SCNN1A and SCNN1G and the activation of ENaC (PubMed 24124190, PubMed 24043776). {ECO 0000269|PubMed 11244092, ECO 0000269|PubMed 12167593, ECO 0000269|PubMed 16423824, ECO 0000269|PubMed 22493497, ECO 0000269|PubMed 24043776, ECO 0000269|PubMed 24124190, ECO 0000269|PubMed 7499195, ECO 0000269|PubMed 9169421}. 
# TCDB	1.A.6.1	the epithelial na(+) channel (enac) family
# TIGRFAMs	TIGR00859	ENaC
# TISSUE SPECIFICITY	SCNNB_HUMAN	Detected in placenta, lung and kidney (PubMed 7762608). Expressed in kidney (at protein level) (PubMed 22207244). {ECO 0000269|PubMed 22207244, ECO 0000269|PubMed 7762608}. 
# UCSC	uc002dln	human. [P51168-1]
# eggNOG	ENOG410ZNFK	LUCA
# eggNOG	KOG4294	Eukaryota
BLAST	swissprot:SCNNB_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SCNNB_HUMAN
BioCyc	ZFISH:ENSG00000168447-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000168447-MONOMER
COXPRESdb	6338	http://coxpresdb.jp/data/gene/6338.shtml
CleanEx	HS_SCNN1B	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SCNN1B
DOI	10.1006/bbrc.1998.9625	http://dx.doi.org/10.1006/bbrc.1998.9625
DOI	10.1006/geno.1995.1188	http://dx.doi.org/10.1006/geno.1995.1188
DOI	10.1006/geno.1999.5927	http://dx.doi.org/10.1006/geno.1999.5927
DOI	10.1007/s00418-011-0904-1	http://dx.doi.org/10.1007/s00418-011-0904-1
DOI	10.1016/0092-8674(94)90250-X	http://dx.doi.org/10.1016/0092-8674(94)90250-X
DOI	10.1016/j.gene.2015.12.061	http://dx.doi.org/10.1016/j.gene.2015.12.061
DOI	10.1016/j.jsbmb.2008.06.013	http://dx.doi.org/10.1016/j.jsbmb.2008.06.013
DOI	10.1016/j.jsbmb.2010.01.002	http://dx.doi.org/10.1016/j.jsbmb.2010.01.002
DOI	10.1038/ng0396-248	http://dx.doi.org/10.1038/ng0396-248
DOI	10.1038/ng0995-76	http://dx.doi.org/10.1038/ng0995-76
DOI	10.1073/pnas.1311999110	http://dx.doi.org/10.1073/pnas.1311999110
DOI	10.1073/pnas.92.25.11495	http://dx.doi.org/10.1073/pnas.92.25.11495
DOI	10.1074/jbc.270.46.27411	http://dx.doi.org/10.1074/jbc.270.46.27411
DOI	10.1074/jbc.272.23.14611	http://dx.doi.org/10.1074/jbc.272.23.14611
DOI	10.1074/jbc.C000906200	http://dx.doi.org/10.1074/jbc.C000906200
DOI	10.1074/jbc.M112.363382	http://dx.doi.org/10.1074/jbc.M112.363382
DOI	10.1074/jbc.M512293200	http://dx.doi.org/10.1074/jbc.M512293200
DOI	10.1093/hmg/ddi374	http://dx.doi.org/10.1093/hmg/ddi374
DOI	10.1097/00004872-199816080-00008	http://dx.doi.org/10.1097/00004872-199816080-00008
DOI	10.1097/00004872-200305000-00016	http://dx.doi.org/10.1097/00004872-200305000-00016
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/j.1365-2265.2005.02255.x	http://dx.doi.org/10.1111/j.1365-2265.2005.02255.x
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1152/ajplung.00103.2013	http://dx.doi.org/10.1152/ajplung.00103.2013
DOI	10.1152/ajprenal.00080.2002	http://dx.doi.org/10.1152/ajprenal.00080.2002
DOI	10.1161/01.HYP.32.1.129	http://dx.doi.org/10.1161/01.HYP.32.1.129
DOI	10.1172/JCI118606	http://dx.doi.org/10.1172/JCI118606
DOI	10.1186/1465-9921-9-46	http://dx.doi.org/10.1186/1465-9921-9-46
DOI	10.1210/jc.2004-1027	http://dx.doi.org/10.1210/jc.2004-1027
DOI	10.1210/jc.84.7.2434	http://dx.doi.org/10.1210/jc.84.7.2434
DOI	10.1210/jcem-73-5-936	http://dx.doi.org/10.1210/jcem-73-5-936
DOI	10.1210/jcem.83.6.5030	http://dx.doi.org/10.1210/jcem.83.6.5030
DOI	10.1210/jcem.87.7.8674	http://dx.doi.org/10.1210/jcem.87.7.8674
DOI	10.1378/chest.08-2246	http://dx.doi.org/10.1378/chest.08-2246
DrugBank	DB00384	http://www.drugbank.ca/drugs/DB00384
DrugBank	DB00594	http://www.drugbank.ca/drugs/DB00594
EMBL	AC130452	http://www.ebi.ac.uk/ena/data/view/AC130452
EMBL	AF260226	http://www.ebi.ac.uk/ena/data/view/AF260226
EMBL	AJ005383	http://www.ebi.ac.uk/ena/data/view/AJ005383
EMBL	AJ005384	http://www.ebi.ac.uk/ena/data/view/AJ005384
EMBL	AJ005385	http://www.ebi.ac.uk/ena/data/view/AJ005385
EMBL	AJ005386	http://www.ebi.ac.uk/ena/data/view/AJ005386
EMBL	AJ005387	http://www.ebi.ac.uk/ena/data/view/AJ005387
EMBL	AJ005388	http://www.ebi.ac.uk/ena/data/view/AJ005388
EMBL	AJ005389	http://www.ebi.ac.uk/ena/data/view/AJ005389
EMBL	AJ005390	http://www.ebi.ac.uk/ena/data/view/AJ005390
EMBL	AJ005391	http://www.ebi.ac.uk/ena/data/view/AJ005391
EMBL	AJ005392	http://www.ebi.ac.uk/ena/data/view/AJ005392
EMBL	AJ005393	http://www.ebi.ac.uk/ena/data/view/AJ005393
EMBL	BC036352	http://www.ebi.ac.uk/ena/data/view/BC036352
EMBL	FJ515831	http://www.ebi.ac.uk/ena/data/view/FJ515831
EMBL	L36593	http://www.ebi.ac.uk/ena/data/view/L36593
EMBL	U16023	http://www.ebi.ac.uk/ena/data/view/U16023
EMBL	X87159	http://www.ebi.ac.uk/ena/data/view/X87159
Ensembl	ENST00000307331	http://www.ensembl.org/id/ENST00000307331
Ensembl	ENST00000343070	http://www.ensembl.org/id/ENST00000343070
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0009897	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009897
GO_component	GO:0016324	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324
GO_component	GO:0030659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030659
GO_component	GO:0034706	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034706
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0015280	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015280
GO_function	GO:0050699	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050699
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0007588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007588
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0035725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035725
GO_process	GO:0050891	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050891
GO_process	GO:0050896	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050896
GO_process	GO:0050909	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050909
GO_process	GO:0055078	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055078
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SCNN1B	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SCNN1B
GeneID	6338	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6338
GeneTree	ENSGT00760000119120	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119120
H-InvDB	HIX0026943	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0026943
HGNC	HGNC:10600	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10600
HOGENOM	HOG000236286	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236286&db=HOGENOM6
HOVERGEN	HBG058435	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG058435&db=HOVERGEN
HPA	HPA015612	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA015612
InParanoid	P51168	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P51168
IntAct	P51168	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P51168*
InterPro	IPR001873	http://www.ebi.ac.uk/interpro/entry/IPR001873
InterPro	IPR004724	http://www.ebi.ac.uk/interpro/entry/IPR004724
InterPro	IPR020903	http://www.ebi.ac.uk/interpro/entry/IPR020903
Jabion	6338	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6338
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00242	http://www.genome.jp/dbget-bin/www_bget?H00242
KEGG_Disease	H00243	http://www.genome.jp/dbget-bin/www_bget?H00243
KEGG_Disease	H00892	http://www.genome.jp/dbget-bin/www_bget?H00892
KEGG_Disease	H01633	http://www.genome.jp/dbget-bin/www_bget?H01633
KEGG_Gene	hsa:6338	http://www.genome.jp/dbget-bin/www_bget?hsa:6338
KEGG_Orthology	KO:K04825	http://www.genome.jp/dbget-bin/www_bget?KO:K04825
KEGG_Pathway	ko04742	http://www.genome.jp/kegg-bin/show_pathway?ko04742
KEGG_Pathway	ko04960	http://www.genome.jp/kegg-bin/show_pathway?ko04960
MIM	177200	http://www.ncbi.nlm.nih.gov/omim/177200
MIM	211400	http://www.ncbi.nlm.nih.gov/omim/211400
MIM	264350	http://www.ncbi.nlm.nih.gov/omim/264350
MIM	600760	http://www.ncbi.nlm.nih.gov/omim/600760
MINT	MINT-198733	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-198733
OMA	CNDTQYK	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CNDTQYK
Orphanet	171876	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=171876
Orphanet	526	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=526
Orphanet	60033	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=60033
OrthoDB	EOG091G0KW6	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0KW6
PANTHER	PTHR11690	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11690
PRINTS	PR01078	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01078
PROSITE	PS01206	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01206
PSORT	swissprot:SCNNB_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SCNNB_HUMAN
PSORT-B	swissprot:SCNNB_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SCNNB_HUMAN
PSORT2	swissprot:SCNNB_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SCNNB_HUMAN
Pfam	PF00858	http://pfam.xfam.org/family/PF00858
PharmGKB	PA306	http://www.pharmgkb.org/do/serve?objId=PA306&objCls=Gene
Phobius	swissprot:SCNNB_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SCNNB_HUMAN
PhylomeDB	P51168	http://phylomedb.org/?seqid=P51168
ProteinModelPortal	P51168	http://www.proteinmodelportal.org/query/uniprot/P51168
PubMed	10404817	http://www.ncbi.nlm.nih.gov/pubmed/10404817
PubMed	10493829	http://www.ncbi.nlm.nih.gov/pubmed/10493829
PubMed	11244092	http://www.ncbi.nlm.nih.gov/pubmed/11244092
PubMed	12107247	http://www.ncbi.nlm.nih.gov/pubmed/12107247
PubMed	12167593	http://www.ncbi.nlm.nih.gov/pubmed/12167593
PubMed	12714866	http://www.ncbi.nlm.nih.gov/pubmed/12714866
PubMed	15483078	http://www.ncbi.nlm.nih.gov/pubmed/15483078
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15853823	http://www.ncbi.nlm.nih.gov/pubmed/15853823
PubMed	16207733	http://www.ncbi.nlm.nih.gov/pubmed/16207733
PubMed	16423824	http://www.ncbi.nlm.nih.gov/pubmed/16423824
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	18507830	http://www.ncbi.nlm.nih.gov/pubmed/18507830
PubMed	18634878	http://www.ncbi.nlm.nih.gov/pubmed/18634878
PubMed	19017867	http://www.ncbi.nlm.nih.gov/pubmed/19017867
PubMed	1939532	http://www.ncbi.nlm.nih.gov/pubmed/1939532
PubMed	20064610	http://www.ncbi.nlm.nih.gov/pubmed/20064610
PubMed	22207244	http://www.ncbi.nlm.nih.gov/pubmed/22207244
PubMed	22493497	http://www.ncbi.nlm.nih.gov/pubmed/22493497
PubMed	23547933	http://www.ncbi.nlm.nih.gov/pubmed/23547933
PubMed	24043776	http://www.ncbi.nlm.nih.gov/pubmed/24043776
PubMed	24124190	http://www.ncbi.nlm.nih.gov/pubmed/24124190
PubMed	26772908	http://www.ncbi.nlm.nih.gov/pubmed/26772908
PubMed	7490094	http://www.ncbi.nlm.nih.gov/pubmed/7490094
PubMed	7499195	http://www.ncbi.nlm.nih.gov/pubmed/7499195
PubMed	7550319	http://www.ncbi.nlm.nih.gov/pubmed/7550319
PubMed	7762608	http://www.ncbi.nlm.nih.gov/pubmed/7762608
PubMed	7954808	http://www.ncbi.nlm.nih.gov/pubmed/7954808
PubMed	8524790	http://www.ncbi.nlm.nih.gov/pubmed/8524790
PubMed	8589714	http://www.ncbi.nlm.nih.gov/pubmed/8589714
PubMed	8601645	http://www.ncbi.nlm.nih.gov/pubmed/8601645
PubMed	9169421	http://www.ncbi.nlm.nih.gov/pubmed/9169421
PubMed	9626162	http://www.ncbi.nlm.nih.gov/pubmed/9626162
PubMed	9674649	http://www.ncbi.nlm.nih.gov/pubmed/9674649
PubMed	9794716	http://www.ncbi.nlm.nih.gov/pubmed/9794716
PubMed	9813171	http://www.ncbi.nlm.nih.gov/pubmed/9813171
Reactome	R-HSA-2672351	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2672351
RefSeq	NP_000327	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000327
STRING	9606.ENSP00000345751	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000345751&targetmode=cogs
TCDB	1.A.6.1	http://www.tcdb.org/search/result.php?tc=1.A.6.1
TIGRFAMs	TIGR00859	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00859
UCSC	uc002dln	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002dln&org=rat
UniGene	Hs.414614	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.414614
UniProtKB	SCNNB_HUMAN	http://www.uniprot.org/uniprot/SCNNB_HUMAN
UniProtKB-AC	P51168	http://www.uniprot.org/uniprot/P51168
charge	swissprot:SCNNB_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SCNNB_HUMAN
eggNOG	ENOG410ZNFK	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZNFK
eggNOG	KOG4294	http://eggnogapi.embl.de/nog_data/html/tree/KOG4294
epestfind	swissprot:SCNNB_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SCNNB_HUMAN
garnier	swissprot:SCNNB_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SCNNB_HUMAN
helixturnhelix	swissprot:SCNNB_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SCNNB_HUMAN
hmoment	swissprot:SCNNB_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SCNNB_HUMAN
iep	swissprot:SCNNB_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SCNNB_HUMAN
inforesidue	swissprot:SCNNB_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SCNNB_HUMAN
neXtProt	NX_P51168	http://www.nextprot.org/db/entry/NX_P51168
octanol	swissprot:SCNNB_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SCNNB_HUMAN
pepcoil	swissprot:SCNNB_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SCNNB_HUMAN
pepdigest	swissprot:SCNNB_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SCNNB_HUMAN
pepinfo	swissprot:SCNNB_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SCNNB_HUMAN
pepnet	swissprot:SCNNB_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SCNNB_HUMAN
pepstats	swissprot:SCNNB_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SCNNB_HUMAN
pepwheel	swissprot:SCNNB_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SCNNB_HUMAN
pepwindow	swissprot:SCNNB_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SCNNB_HUMAN
sigcleave	swissprot:SCNNB_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SCNNB_HUMAN
## Database	ID	URL or Descriptions
# AltName	GTR8_HUMAN	Glucose transporter type 8
# AltName	GTR8_HUMAN	Glucose transporter type X1
# BioGrid	119013	9
# CDD	cd06174	MFS
# Ensembl	ENST00000373371	ENSP00000362469; ENSG00000136856
# ExpressionAtlas	Q9NY64	baseline and differential
# FUNCTION	GTR8_HUMAN	Insulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose (By similarity). {ECO 0000250}. 
# GO_component	GO:0005765	lysosomal membrane; IDA:UniProtKB.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0008021	synaptic vesicle; IEA:Ensembl.
# GO_component	GO:0030659	cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0005355	glucose transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0005536	glucose binding; IEA:Ensembl.
# GO_function	GO:0055056	D-glucose transmembrane transporter activity; TAS:Reactome.
# GO_function	GTR8_HUMAN	GO 0005351 sugar proton symporter activity; IBA GO_Central.
# GO_process	GO:0001666	response to hypoxia; IEA:Ensembl.
# GO_process	GO:0005975	carbohydrate metabolic process; TAS:ProtInc.
# GO_process	GO:0007141	male meiosis I; IEA:Ensembl.
# GO_process	GO:0008286	insulin receptor signaling pathway; IEA:Ensembl.
# GO_process	GO:0015758	glucose transport; TAS:ProtInc.
# GO_process	GO:0046323	glucose import; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0005975	carbohydrate metabolic process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# Genevisible	Q9NY64	HS
# HGNC	HGNC:13812	SLC2A8
# INDUCTION	GTR8_HUMAN	In testis, down-regulated by estrogen. 
# InterPro	IPR003663	Sugar/inositol_transpt
# InterPro	IPR005828	MFS_sugar_transport-like
# InterPro	IPR005829	Sugar_transporter_CS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko02000	Transporters
# MIM	605245	gene
# Organism	GTR8_HUMAN	Homo sapiens (Human)
# PRINTS	PR00171	SUGRTRNSPORT
# PROSITE	PS00216	SUGAR_TRANSPORT_1; 2
# PROSITE	PS00217	SUGAR_TRANSPORT_2
# PROSITE	PS50850	MFS
# Pfam	PF00083	Sugar_tr
# Proteomes	UP000005640	Chromosome 9
# Reactome	R-HSA-428790	Facilitative Na+-independent glucose transporters
# Reactome	R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis
# Reactome	R-HSA-8856828	Clathrin-mediated endocytosis
# RecName	GTR8_HUMAN	Solute carrier family 2, facilitated glucose transporter member 8
# RefSeq	NP_001258640	NM_001271711.1
# RefSeq	NP_001258641	NM_001271712.1
# RefSeq	NP_055395	NM_014580.4
# SIMILARITY	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	GTR8_HUMAN	Cell membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Cytoplasmic vesicle membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Note=Principally intracellular. May move between intracellular vesicles and the plasma membrane. The dileucine internalization motif is critical for intracellular sequestration (By similarity). {ECO 0000250}. 
# SUBUNIT	Interacts with AP2B1. {ECO	0000250}. 
# SUPFAM	SSF103473	SSF103473; 2
# TCDB	2.A.1.1.89	the major facilitator superfamily (mfs)
# TIGRFAMs	TIGR00879	SP
# TISSUE SPECIFICITY	GTR8_HUMAN	Highly expressed in testis, but not in testicular carcinoma. Lower amounts present in most other tissues. 
# UCSC	uc004bqu	human
# eggNOG	ENOG410XNQK	LUCA
# eggNOG	KOG0254	Eukaryota
BLAST	swissprot:GTR8_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GTR8_HUMAN
BioCyc	ZFISH:ENSG00000136856-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000136856-MONOMER
COXPRESdb	29988	http://coxpresdb.jp/data/gene/29988.shtml
CleanEx	HS_SLC2A8	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC2A8
DOI	10.1038/nature02465	http://dx.doi.org/10.1038/nature02465
DOI	10.1074/jbc.275.21.16275	http://dx.doi.org/10.1074/jbc.275.21.16275
DOI	10.1074/jbc.275.7.4607	http://dx.doi.org/10.1074/jbc.275.7.4607
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AJ245937	http://www.ebi.ac.uk/ena/data/view/AJ245937
EMBL	AL445222	http://www.ebi.ac.uk/ena/data/view/AL445222
EMBL	BC019043	http://www.ebi.ac.uk/ena/data/view/BC019043
EMBL	CH471090	http://www.ebi.ac.uk/ena/data/view/CH471090
EMBL	Y17801	http://www.ebi.ac.uk/ena/data/view/Y17801
Ensembl	ENST00000373371	http://www.ensembl.org/id/ENST00000373371
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005765
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0008021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008021
GO_component	GO:0030659	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030659
GO_function	GO:0005351	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005351
GO_function	GO:0005355	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005355
GO_function	GO:0005536	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005536
GO_function	GO:0055056	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055056
GO_process	GO:0001666	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001666
GO_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GO_process	GO:0007141	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007141
GO_process	GO:0008286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008286
GO_process	GO:0015758	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015758
GO_process	GO:0046323	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046323
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0005975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GeneCards	SLC2A8	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC2A8
GeneID	29988	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29988
GeneTree	ENSGT00850000132274	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00850000132274
HGNC	HGNC:13812	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:13812
HOGENOM	HOG000202868	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202868&db=HOGENOM6
HOVERGEN	HBG104335	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG104335&db=HOVERGEN
HPA	HPA011935	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA011935
InParanoid	Q9NY64	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9NY64
InterPro	IPR003663	http://www.ebi.ac.uk/interpro/entry/IPR003663
InterPro	IPR005828	http://www.ebi.ac.uk/interpro/entry/IPR005828
InterPro	IPR005829	http://www.ebi.ac.uk/interpro/entry/IPR005829
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	29988	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=29988
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:29988	http://www.genome.jp/dbget-bin/www_bget?hsa:29988
KEGG_Orthology	KO:K08145	http://www.genome.jp/dbget-bin/www_bget?KO:K08145
MIM	605245	http://www.ncbi.nlm.nih.gov/omim/605245
OMA	HRHQEAM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HRHQEAM
OrthoDB	EOG091G1600	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G1600
PRINTS	PR00171	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00171
PROSITE	PS00216	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00216
PROSITE	PS00217	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00217
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:GTR8_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GTR8_HUMAN
PSORT-B	swissprot:GTR8_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GTR8_HUMAN
PSORT2	swissprot:GTR8_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GTR8_HUMAN
Pfam	PF00083	http://pfam.xfam.org/family/PF00083
PharmGKB	PA37813	http://www.pharmgkb.org/do/serve?objId=PA37813&objCls=Gene
Phobius	swissprot:GTR8_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GTR8_HUMAN
PhylomeDB	Q9NY64	http://phylomedb.org/?seqid=Q9NY64
ProteinModelPortal	Q9NY64	http://www.proteinmodelportal.org/query/uniprot/Q9NY64
PubMed	10671487	http://www.ncbi.nlm.nih.gov/pubmed/10671487
PubMed	10821868	http://www.ncbi.nlm.nih.gov/pubmed/10821868
PubMed	15164053	http://www.ncbi.nlm.nih.gov/pubmed/15164053
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
Reactome	R-HSA-428790	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428790
Reactome	R-HSA-8856825	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8856825
Reactome	R-HSA-8856828	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8856828
RefSeq	NP_001258640	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001258640
RefSeq	NP_001258641	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001258641
RefSeq	NP_055395	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055395
STRING	9606.ENSP00000362469	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000362469&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.1.89	http://www.tcdb.org/search/result.php?tc=2.A.1.1.89
TIGRFAMs	TIGR00879	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00879
UCSC	uc004bqu	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004bqu&org=rat
UniGene	Hs.179522	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.179522
UniProtKB	GTR8_HUMAN	http://www.uniprot.org/uniprot/GTR8_HUMAN
UniProtKB-AC	Q9NY64	http://www.uniprot.org/uniprot/Q9NY64
charge	swissprot:GTR8_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GTR8_HUMAN
eggNOG	ENOG410XNQK	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNQK
eggNOG	KOG0254	http://eggnogapi.embl.de/nog_data/html/tree/KOG0254
epestfind	swissprot:GTR8_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GTR8_HUMAN
garnier	swissprot:GTR8_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GTR8_HUMAN
helixturnhelix	swissprot:GTR8_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GTR8_HUMAN
hmoment	swissprot:GTR8_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GTR8_HUMAN
iep	swissprot:GTR8_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GTR8_HUMAN
inforesidue	swissprot:GTR8_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GTR8_HUMAN
neXtProt	NX_Q9NY64	http://www.nextprot.org/db/entry/NX_Q9NY64
octanol	swissprot:GTR8_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GTR8_HUMAN
pepcoil	swissprot:GTR8_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GTR8_HUMAN
pepdigest	swissprot:GTR8_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GTR8_HUMAN
pepinfo	swissprot:GTR8_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GTR8_HUMAN
pepnet	swissprot:GTR8_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GTR8_HUMAN
pepstats	swissprot:GTR8_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GTR8_HUMAN
pepwheel	swissprot:GTR8_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GTR8_HUMAN
pepwindow	swissprot:GTR8_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GTR8_HUMAN
sigcleave	swissprot:GTR8_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GTR8_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	Event=Alternative splicing; Named isoforms=3; Name=3; IsoId=P45880-3; Sequence=Displayed; Name=1; IsoId=P45880-1; Sequence=VSP_005077; Note=Ref.1 (AAA60144) sequence differs from that shown due to a frameshift in position 303. {ECO:0000305}; Name=2; IsoId=P45880-2; Sequence=VSP_005076; Note=Ref.1 (AAA60145) sequence differs from that shown due to a frameshift in position 277. {ECO	0000305}; 
# AltName	VDAC2_HUMAN	Outer mitochondrial membrane protein porin 2
# BioGrid	113260	129
# CCDS	CCDS53544	-. [P45880-1]
# CCDS	CCDS7348	-. [P45880-3]
# DOMAIN	VDAC2_HUMAN	Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. {ECO 0000250}. 
# DrugBank	DB01375	Dihydroxyaluminium
# Ensembl	ENST00000313132	ENSP00000361635; ENSG00000165637. [P45880-1]
# Ensembl	ENST00000332211	ENSP00000361686; ENSG00000165637. [P45880-3]
# Ensembl	ENST00000543351	ENSP00000443092; ENSG00000165637. [P45880-3]
# ExpressionAtlas	P45880	baseline and differential
# FUNCTION	VDAC2_HUMAN	Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective. 
# GO_component	GO:0005634	nucleus; IDA:UniProtKB.
# GO_component	GO:0005739	mitochondrion; IDA:UniProtKB.
# GO_component	GO:0005741	mitochondrial outer membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:0005743	mitochondrial inner membrane; IEA:Ensembl.
# GO_component	GO:0008021	synaptic vesicle; IEA:Ensembl.
# GO_component	GO:0042645	mitochondrial nucleoid; IDA:BHF-UCL.
# GO_component	GO:0043209	myelin sheath; IEA:Ensembl.
# GO_component	GO:0045121	membrane raft; IDA:UniProtKB.
# GO_component	GO:0046930	pore complex; IEA:UniProtKB-KW.
# GO_component	GO:0070062	extracellular exosome; IDA:UniProtKB.
# GO_function	GO:0000166	nucleotide binding; IEA:UniProtKB-KW.
# GO_function	GO:0008308	voltage-gated anion channel activity; IDA:UniProtKB.
# GO_function	GO:0015288	porin activity; IEA:UniProtKB-KW.
# GO_process	GO:0006820	anion transport; IDA:UniProtKB.
# GO_process	GO:0032272	negative regulation of protein polymerization; IEA:Ensembl.
# GO_process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_component	GO:0005739	mitochondrion
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# Gene3D	2.40.160.10	-; 1.
# Genevisible	P45880	HS
# HGNC	HGNC:12672	VDAC2
# INTERACTION	VDAC2_HUMAN	Q96A26 FAM162A; NbExp=2; IntAct=EBI-354022, EBI-6123466; 
# IntAct	P45880	43
# InterPro	IPR001925	Porin_Euk
# InterPro	IPR023614	Porin_dom
# InterPro	IPR027246	Porin_Euk/Tom40
# InterPro	IPR030277	VDAC2
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko05012	Parkinson's disease
# KEGG_Pathway	ko05016	Huntington's disease
# KEGG_Pathway	ko05166	HTLV-I infection
# MIM	193245	gene
# Organism	VDAC2_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR11743:SF12	PTHR11743:SF12
# PIR	A45972	A45972
# PIR	B44422	B44422
# PRINTS	PR00185	EUKARYTPORIN
# PROSITE	PS00558	EUKARYOTIC_PORIN
# PTM	VDAC2_HUMAN	Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. {ECO 0000269|PubMed 25621951}. 
# Pfam	PF01459	Porin_3
# Proteomes	UP000005640	Chromosome 10
# Reactome	R-HSA-5689880	Ub-specific processing proteases
# RecName	VDAC2_HUMAN	Voltage-dependent anion-selective channel protein 2
# RefSeq	NP_001171712	NM_001184783.2. [P45880-1]
# RefSeq	NP_001171752	NM_001184823.1. [P45880-3]
# RefSeq	NP_001311017	NM_001324088.1. [P45880-3]
# RefSeq	NP_003366	NM_003375.4. [P45880-3]
# SEQUENCE CAUTION	Sequence=CAH73106.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40910.1; Type=Erroneous gene model prediction; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the eukaryotic mitochondrial porin family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	VDAC2_HUMAN	Mitochondrion outer membrane {ECO 0000269|PubMed 7539795}. 
# SUBUNIT	Interacts with hexokinases. {ECO	0000250}. 
# TCDB	1.B.8.1.12	the mitochondrial and plastid porin (mpp) family
# TISSUE SPECIFICITY	VDAC2_HUMAN	Expressed in all tissues examined. 
# TopDownProteomics	P45880-3	-. [P45880-3]
# UCSC	uc001jwz	human. [P45880-3]
# eggNOG	ENOG410ZBK1	LUCA
# eggNOG	KOG3126	Eukaryota
BLAST	swissprot:VDAC2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VDAC2_HUMAN
BioCyc	ZFISH:ENSG00000165637-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000165637-MONOMER
COXPRESdb	7417	http://coxpresdb.jp/data/gene/7417.shtml
CleanEx	HS_VDAC2	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_VDAC2
DOI	10.1002/pmic.201400617	http://dx.doi.org/10.1002/pmic.201400617
DOI	10.1007/s003359901158	http://dx.doi.org/10.1007/s003359901158
DOI	10.1016/j.cell.2006.09.026	http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1016/j.molcel.2008.07.007	http://dx.doi.org/10.1016/j.molcel.2008.07.007
DOI	10.1021/ac9004309	http://dx.doi.org/10.1021/ac9004309
DOI	10.1021/pr0704130	http://dx.doi.org/10.1021/pr0704130
DOI	10.1021/pr300630k	http://dx.doi.org/10.1021/pr300630k
DOI	10.1038/nature02462	http://dx.doi.org/10.1038/nature02462
DOI	10.1038/ncb3097	http://dx.doi.org/10.1038/ncb3097
DOI	10.1073/pnas.0805139105	http://dx.doi.org/10.1073/pnas.0805139105
DOI	10.1074/jbc.270.23.13998	http://dx.doi.org/10.1074/jbc.270.23.13998
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1175371	http://dx.doi.org/10.1126/science.1175371
DOI	10.1126/scisignal.2000475	http://dx.doi.org/10.1126/scisignal.2000475
DOI	10.1126/scisignal.2001570	http://dx.doi.org/10.1126/scisignal.2001570
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
DrugBank	DB01375	http://www.drugbank.ca/drugs/DB01375
EMBL	AF152220	http://www.ebi.ac.uk/ena/data/view/AF152220
EMBL	AF152221	http://www.ebi.ac.uk/ena/data/view/AF152221
EMBL	AF152222	http://www.ebi.ac.uk/ena/data/view/AF152222
EMBL	AF152223	http://www.ebi.ac.uk/ena/data/view/AF152223
EMBL	AF152224	http://www.ebi.ac.uk/ena/data/view/AF152224
EMBL	AF152225	http://www.ebi.ac.uk/ena/data/view/AF152225
EMBL	AF152226	http://www.ebi.ac.uk/ena/data/view/AF152226
EMBL	AF152227	http://www.ebi.ac.uk/ena/data/view/AF152227
EMBL	AL390034	http://www.ebi.ac.uk/ena/data/view/AL390034
EMBL	AL390034	http://www.ebi.ac.uk/ena/data/view/AL390034
EMBL	AL390034	http://www.ebi.ac.uk/ena/data/view/AL390034
EMBL	AL390034	http://www.ebi.ac.uk/ena/data/view/AL390034
EMBL	AL390034	http://www.ebi.ac.uk/ena/data/view/AL390034
EMBL	AL390034	http://www.ebi.ac.uk/ena/data/view/AL390034
EMBL	AL392111	http://www.ebi.ac.uk/ena/data/view/AL392111
EMBL	AL392111	http://www.ebi.ac.uk/ena/data/view/AL392111
EMBL	AL392111	http://www.ebi.ac.uk/ena/data/view/AL392111
EMBL	AL392111	http://www.ebi.ac.uk/ena/data/view/AL392111
EMBL	AL392111	http://www.ebi.ac.uk/ena/data/view/AL392111
EMBL	AL392111	http://www.ebi.ac.uk/ena/data/view/AL392111
EMBL	BC000165	http://www.ebi.ac.uk/ena/data/view/BC000165
EMBL	BC012883	http://www.ebi.ac.uk/ena/data/view/BC012883
EMBL	BC072407	http://www.ebi.ac.uk/ena/data/view/BC072407
EMBL	CR456964	http://www.ebi.ac.uk/ena/data/view/CR456964
EMBL	L06328	http://www.ebi.ac.uk/ena/data/view/L06328
EMBL	L08666	http://www.ebi.ac.uk/ena/data/view/L08666
EMBL	L08666	http://www.ebi.ac.uk/ena/data/view/L08666
Ensembl	ENST00000313132	http://www.ensembl.org/id/ENST00000313132
Ensembl	ENST00000332211	http://www.ensembl.org/id/ENST00000332211
Ensembl	ENST00000543351	http://www.ensembl.org/id/ENST00000543351
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GO_component	GO:0005741	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005741
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0008021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008021
GO_component	GO:0042645	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042645
GO_component	GO:0043209	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043209
GO_component	GO:0045121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045121
GO_component	GO:0046930	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046930
GO_component	GO:0070062	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070062
GO_function	GO:0000166	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166
GO_function	GO:0008308	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008308
GO_function	GO:0015288	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015288
GO_process	GO:0006820	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006820
GO_process	GO:0032272	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032272
GO_process	GO:2001243	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001243
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_component	GO:0005739	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005739
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
Gene3D	2.40.160.10	http://www.cathdb.info/version/latest/superfamily/2.40.160.10
GeneCards	VDAC2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=VDAC2
GeneID	7417	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7417
GeneTree	ENSGT00390000011336	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000011336
H-InvDB	HIX0029994	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0029994
HGNC	HGNC:12672	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:12672
HOVERGEN	HBG054036	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG054036&db=HOVERGEN
HPA	HPA043475	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA043475
InParanoid	P45880	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45880
IntAct	P45880	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45880*
InterPro	IPR001925	http://www.ebi.ac.uk/interpro/entry/IPR001925
InterPro	IPR023614	http://www.ebi.ac.uk/interpro/entry/IPR023614
InterPro	IPR027246	http://www.ebi.ac.uk/interpro/entry/IPR027246
InterPro	IPR030277	http://www.ebi.ac.uk/interpro/entry/IPR030277
Jabion	7417	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7417
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:7417	http://www.genome.jp/dbget-bin/www_bget?hsa:7417
KEGG_Orthology	KO:K15040	http://www.genome.jp/dbget-bin/www_bget?KO:K15040
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko05012	http://www.genome.jp/kegg-bin/show_pathway?ko05012
KEGG_Pathway	ko05016	http://www.genome.jp/kegg-bin/show_pathway?ko05016
KEGG_Pathway	ko05166	http://www.genome.jp/kegg-bin/show_pathway?ko05166
MIM	193245	http://www.ncbi.nlm.nih.gov/omim/193245
MINT	MINT-3016132	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-3016132
OMA	MCVPPSY	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MCVPPSY
OrthoDB	EOG091G0F0O	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0F0O
PANTHER	PTHR11743:SF12	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11743:SF12
PRINTS	PR00185	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00185
PROSITE	PS00558	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00558
PSORT	swissprot:VDAC2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VDAC2_HUMAN
PSORT-B	swissprot:VDAC2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VDAC2_HUMAN
PSORT2	swissprot:VDAC2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VDAC2_HUMAN
Pfam	PF01459	http://pfam.xfam.org/family/PF01459
PharmGKB	PA37295	http://www.pharmgkb.org/do/serve?objId=PA37295&objCls=Gene
Phobius	swissprot:VDAC2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VDAC2_HUMAN
PhylomeDB	P45880	http://phylomedb.org/?seqid=P45880
ProteinModelPortal	P45880	http://www.proteinmodelportal.org/query/uniprot/P45880
PubMed	10501981	http://www.ncbi.nlm.nih.gov/pubmed/10501981
PubMed	15164054	http://www.ncbi.nlm.nih.gov/pubmed/15164054
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17081983	http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed	18088087	http://www.ncbi.nlm.nih.gov/pubmed/18088087
PubMed	18669648	http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed	18691976	http://www.ncbi.nlm.nih.gov/pubmed/18691976
PubMed	19413330	http://www.ncbi.nlm.nih.gov/pubmed/19413330
PubMed	19608861	http://www.ncbi.nlm.nih.gov/pubmed/19608861
PubMed	20068231	http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	21406692	http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed	23186163	http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
PubMed	25621951	http://www.ncbi.nlm.nih.gov/pubmed/25621951
PubMed	25944712	http://www.ncbi.nlm.nih.gov/pubmed/25944712
PubMed	7539795	http://www.ncbi.nlm.nih.gov/pubmed/7539795
PubMed	7685033	http://www.ncbi.nlm.nih.gov/pubmed/7685033
PubMed	8420959	http://www.ncbi.nlm.nih.gov/pubmed/8420959
Reactome	R-HSA-5689880	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5689880
RefSeq	NP_001171712	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001171712
RefSeq	NP_001171752	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001171752
RefSeq	NP_001311017	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001311017
RefSeq	NP_003366	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003366
SMR	P45880	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45880
STRING	9606.ENSP00000361635	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000361635&targetmode=cogs
SWISS-2DPAGE	P45880	http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P45880
TCDB	1.B.8.1.12	http://www.tcdb.org/search/result.php?tc=1.B.8.1.12
UCSC	uc001jwz	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001jwz&org=rat
UniGene	Hs.355927	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.355927
UniProtKB	VDAC2_HUMAN	http://www.uniprot.org/uniprot/VDAC2_HUMAN
UniProtKB-AC	P45880	http://www.uniprot.org/uniprot/P45880
charge	swissprot:VDAC2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VDAC2_HUMAN
eggNOG	ENOG410ZBK1	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZBK1
eggNOG	KOG3126	http://eggnogapi.embl.de/nog_data/html/tree/KOG3126
epestfind	swissprot:VDAC2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VDAC2_HUMAN
garnier	swissprot:VDAC2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VDAC2_HUMAN
helixturnhelix	swissprot:VDAC2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VDAC2_HUMAN
hmoment	swissprot:VDAC2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VDAC2_HUMAN
iep	swissprot:VDAC2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VDAC2_HUMAN
inforesidue	swissprot:VDAC2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VDAC2_HUMAN
neXtProt	NX_P45880	http://www.nextprot.org/db/entry/NX_P45880
octanol	swissprot:VDAC2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VDAC2_HUMAN
pepcoil	swissprot:VDAC2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VDAC2_HUMAN
pepdigest	swissprot:VDAC2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VDAC2_HUMAN
pepinfo	swissprot:VDAC2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VDAC2_HUMAN
pepnet	swissprot:VDAC2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VDAC2_HUMAN
pepstats	swissprot:VDAC2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VDAC2_HUMAN
pepwheel	swissprot:VDAC2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VDAC2_HUMAN
pepwindow	swissprot:VDAC2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VDAC2_HUMAN
sigcleave	swissprot:VDAC2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VDAC2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	SCN4B_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8IWT1-1; Sequence=Displayed; Name=2; IsoId=Q8IWT1-2; Sequence=VSP_053913; Note=No experimental confirmation available.; Name=3; IsoId=Q8IWT1-3; Sequence=VSP_046971; Note=Gene prediction based on EST data.; 
# CCDS	CCDS44744	-. [Q8IWT1-3]
# CCDS	CCDS8389	-. [Q8IWT1-1]
# ChiTaRS	SCN4B	human
# DISEASE	SCN4B_HUMAN	Atrial fibrillation, familial, 17 (ATFB17) [MIM 611819]  A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. {ECO 0000269|PubMed 23604097}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	SCN4B_HUMAN	Long QT syndrome 10 (LQT10) [MIM 611819]  A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. {ECO 0000269|PubMed 17592081}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DrugBank	DB00313	Valproic Acid
# DrugBank	DB00909	Zonisamide
# Ensembl	ENST00000324727	ENSP00000322460; ENSG00000177098. [Q8IWT1-1]
# Ensembl	ENST00000529878	ENSP00000436343; ENSG00000177098. [Q8IWT1-3]
# ExpressionAtlas	Q8IWT1	baseline and differential
# FUNCTION	SCN4B_HUMAN	Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the suceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom. {ECO 0000269|PubMed 24297919}. 
# GO_component	GO:0001518	voltage-gated sodium channel complex; IDA:UniProtKB.
# GO_component	GO:0014704	intercalated disc; ISS:BHF-UCL.
# GO_component	GO:0031226	intrinsic component of plasma membrane; IDA:UniProtKB.
# GO_function	GO:0005248	voltage-gated sodium channel activity; IDA:UniProtKB.
# GO_function	GO:0017080	sodium channel regulator activity; IDA:UniProtKB.
# GO_function	GO:0044325	ion channel binding; IPI:BHF-UCL.
# GO_function	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential; IMP:BHF-UCL.
# GO_process	GO:0006814	sodium ion transport; IDA:UniProtKB.
# GO_process	GO:0010765	positive regulation of sodium ion transport; IDA:BHF-UCL.
# GO_process	GO:0035725	sodium ion transmembrane transport; IDA:BHF-UCL.
# GO_process	GO:0060048	cardiac muscle contraction; IMP:BHF-UCL.
# GO_process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization; IMP:BHF-UCL.
# GO_process	GO:0086002	cardiac muscle cell action potential involved in contraction; IMP:BHF-UCL.
# GO_process	GO:0086012	membrane depolarization during cardiac muscle cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086016	AV node cell action potential; IMP:BHF-UCL.
# GO_process	GO:0086091	regulation of heart rate by cardiac conduction; IMP:BHF-UCL.
# GO_process	GO:2000649	regulation of sodium ion transmembrane transporter activity; IDA:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.60.40.10	-; 1.
# Genevisible	Q8IWT1	HS
# HGNC	HGNC:10592	SCN4B
# InterPro	IPR000920	Myelin_P0-rel
# InterPro	IPR003599	Ig_sub
# InterPro	IPR007110	Ig-like_dom
# InterPro	IPR013106	Ig_V-set
# InterPro	IPR013783	Ig-like_fold
# KEGG_Brite	ko04040	Ion channels
# KEGG_Disease	H00720	[Cardiovascular disease] Jervell and Lange-Nielsen syndrome (JLNS)
# MIM	608256	gene
# MIM	611819	phenotype
# Organism	SCN4B_HUMAN	Homo sapiens (Human)
# Orphanet	101016	Romano-Ward syndrome
# Orphanet	334	Familial atrial fibrillation
# PANTHER	PTHR13869	PTHR13869
# PDB	4MZ2	X-ray; 1.72 A; A=32-157
# PDB	4MZ3	X-ray; 1.74 A; A/B=32-157
# PROSITE	PS50835	IG_LIKE
# PTM	SCN4B_HUMAN	Contains an interchain disulfide bond with SCN2A. 
# PTM	SCN4B_HUMAN	N-glycosylated. {ECO 0000269|PubMed 24297919}. 
# Pfam	PF07686	V-set
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-445095	Interaction between L1 and Ankyrins
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# RecName	SCN4B_HUMAN	Sodium channel subunit beta-4
# RefSeq	NP_001135820	NM_001142348.1. [Q8IWT1-3]
# RefSeq	NP_001135821	NM_001142349.1. [Q8IWT1-2]
# RefSeq	NP_777594	NM_174934.3. [Q8IWT1-1]
# SIMILARITY	Belongs to the sodium channel auxiliary subunit SCN4B (TC 8.A.17) family. {ECO	0000305}. 
# SIMILARITY	Contains 1 Ig-like C2-type (immunoglobulin-like) domain. {ECO	0000305}.
# SMART	SM00409	IG
# SUBCELLULAR LOCATION	SCN4B_HUMAN	Cell membrane {ECO 0000269|PubMed 24297919}; Single-pass type I membrane protein {ECO 0000269|PubMed 24297919}. 
# SUBUNIT	Component of the voltage-sensitive sodium channel complex that consists of an ion-conducting pore-forming alpha subunit and one or more regulatory beta subunits. Heterooligomer with SCN2A; disulfide-linked. {ECO:0000269|PubMed	24297919}. 
# SUPFAM	SSF48726	SSF48726
# TCDB	8.A.17.2	the na(+) channel auxiliary subunit 1-4 (sca-) family
# TISSUE SPECIFICITY	SCN4B_HUMAN	Expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Expressed in the atrium. {ECO 0000269|PubMed 12930796, ECO 0000269|PubMed 21051419}. 
# UCSC	uc001pse	human. [Q8IWT1-1]
# eggNOG	ENOG410IXQZ	Eukaryota
# eggNOG	ENOG4111PJ2	LUCA
BLAST	swissprot:SCN4B_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:SCN4B_HUMAN
COXPRESdb	6330	http://coxpresdb.jp/data/gene/6330.shtml
CleanEx	HS_SCN4B	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SCN4B
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1073/pnas.1314557110	http://dx.doi.org/10.1073/pnas.1314557110
DOI	10.1093/cvr/cvq348	http://dx.doi.org/10.1093/cvr/cvq348
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1161/CIRCULATIONAHA.106.659086	http://dx.doi.org/10.1161/CIRCULATIONAHA.106.659086
DOI	10.3892/ijmm.2013.1355	http://dx.doi.org/10.3892/ijmm.2013.1355
DrugBank	DB00313	http://www.drugbank.ca/drugs/DB00313
DrugBank	DB00909	http://www.drugbank.ca/drugs/DB00909
EMBL	AP002800	http://www.ebi.ac.uk/ena/data/view/AP002800
EMBL	AY149967	http://www.ebi.ac.uk/ena/data/view/AY149967
EMBL	BC035017	http://www.ebi.ac.uk/ena/data/view/BC035017
Ensembl	ENST00000324727	http://www.ensembl.org/id/ENST00000324727
Ensembl	ENST00000529878	http://www.ensembl.org/id/ENST00000529878
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0001518	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001518
GO_component	GO:0014704	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014704
GO_component	GO:0031226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031226
GO_function	GO:0005248	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005248
GO_function	GO:0017080	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017080
GO_function	GO:0044325	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044325
GO_function	GO:0086006	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086006
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0010765	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010765
GO_process	GO:0035725	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035725
GO_process	GO:0060048	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060048
GO_process	GO:0060307	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060307
GO_process	GO:0086002	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086002
GO_process	GO:0086012	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086012
GO_process	GO:0086016	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086016
GO_process	GO:0086091	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0086091
GO_process	GO:2000649	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000649
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.60.40.10	http://www.cathdb.info/version/latest/superfamily/2.60.40.10
GeneCards	SCN4B	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SCN4B
GeneID	6330	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6330
GeneTree	ENSGT00640000091161	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00640000091161
HGNC	HGNC:10592	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:10592
HOGENOM	HOG000048715	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000048715&db=HOGENOM6
HOVERGEN	HBG056581	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG056581&db=HOVERGEN
HPA	HPA017293	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA017293
InParanoid	Q8IWT1	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8IWT1
InterPro	IPR000920	http://www.ebi.ac.uk/interpro/entry/IPR000920
InterPro	IPR003599	http://www.ebi.ac.uk/interpro/entry/IPR003599
InterPro	IPR007110	http://www.ebi.ac.uk/interpro/entry/IPR007110
InterPro	IPR013106	http://www.ebi.ac.uk/interpro/entry/IPR013106
InterPro	IPR013783	http://www.ebi.ac.uk/interpro/entry/IPR013783
Jabion	6330	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=6330
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H00720	http://www.genome.jp/dbget-bin/www_bget?H00720
KEGG_Gene	hsa:6330	http://www.genome.jp/dbget-bin/www_bget?hsa:6330
KEGG_Orthology	KO:K04848	http://www.genome.jp/dbget-bin/www_bget?KO:K04848
MIM	608256	http://www.ncbi.nlm.nih.gov/omim/608256
MIM	611819	http://www.ncbi.nlm.nih.gov/omim/611819
OMA	REKKKEC	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=REKKKEC
Orphanet	101016	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=101016
Orphanet	334	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=334
OrthoDB	EOG091G0MQV	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0MQV
PANTHER	PTHR13869	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13869
PDB	4MZ2	http://www.ebi.ac.uk/pdbe-srv/view/entry/4MZ2
PDB	4MZ3	http://www.ebi.ac.uk/pdbe-srv/view/entry/4MZ3
PDBsum	4MZ2	http://www.ebi.ac.uk/pdbsum/4MZ2
PDBsum	4MZ3	http://www.ebi.ac.uk/pdbsum/4MZ3
PROSITE	PS50835	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50835
PSORT	swissprot:SCN4B_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:SCN4B_HUMAN
PSORT-B	swissprot:SCN4B_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:SCN4B_HUMAN
PSORT2	swissprot:SCN4B_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:SCN4B_HUMAN
Pfam	PF07686	http://pfam.xfam.org/family/PF07686
PharmGKB	PA35007	http://www.pharmgkb.org/do/serve?objId=PA35007&objCls=Gene
Phobius	swissprot:SCN4B_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:SCN4B_HUMAN
PhylomeDB	Q8IWT1	http://phylomedb.org/?seqid=Q8IWT1
ProteinModelPortal	Q8IWT1	http://www.proteinmodelportal.org/query/uniprot/Q8IWT1
PubMed	12930796	http://www.ncbi.nlm.nih.gov/pubmed/12930796
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	17592081	http://www.ncbi.nlm.nih.gov/pubmed/17592081
PubMed	21051419	http://www.ncbi.nlm.nih.gov/pubmed/21051419
PubMed	23604097	http://www.ncbi.nlm.nih.gov/pubmed/23604097
PubMed	24297919	http://www.ncbi.nlm.nih.gov/pubmed/24297919
Reactome	R-HSA-445095	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-445095
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
RefSeq	NP_001135820	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001135820
RefSeq	NP_001135821	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001135821
RefSeq	NP_777594	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_777594
SMART	SM00409	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00409
SMR	Q8IWT1	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8IWT1
STRING	9606.ENSP00000322460	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000322460&targetmode=cogs
SUPFAM	SSF48726	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48726
TCDB	8.A.17.2	http://www.tcdb.org/search/result.php?tc=8.A.17.2
UCSC	uc001pse	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001pse&org=rat
UniGene	Hs.65239	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.65239
UniProtKB	SCN4B_HUMAN	http://www.uniprot.org/uniprot/SCN4B_HUMAN
UniProtKB-AC	Q8IWT1	http://www.uniprot.org/uniprot/Q8IWT1
charge	swissprot:SCN4B_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:SCN4B_HUMAN
eggNOG	ENOG410IXQZ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IXQZ
eggNOG	ENOG4111PJ2	http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111PJ2
epestfind	swissprot:SCN4B_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:SCN4B_HUMAN
garnier	swissprot:SCN4B_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:SCN4B_HUMAN
helixturnhelix	swissprot:SCN4B_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:SCN4B_HUMAN
hmoment	swissprot:SCN4B_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:SCN4B_HUMAN
iep	swissprot:SCN4B_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:SCN4B_HUMAN
inforesidue	swissprot:SCN4B_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:SCN4B_HUMAN
neXtProt	NX_Q8IWT1	http://www.nextprot.org/db/entry/NX_Q8IWT1
octanol	swissprot:SCN4B_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:SCN4B_HUMAN
pepcoil	swissprot:SCN4B_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:SCN4B_HUMAN
pepdigest	swissprot:SCN4B_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:SCN4B_HUMAN
pepinfo	swissprot:SCN4B_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:SCN4B_HUMAN
pepnet	swissprot:SCN4B_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:SCN4B_HUMAN
pepstats	swissprot:SCN4B_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:SCN4B_HUMAN
pepwheel	swissprot:SCN4B_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:SCN4B_HUMAN
pepwindow	swissprot:SCN4B_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:SCN4B_HUMAN
sigcleave	swissprot:SCN4B_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:SCN4B_HUMAN
## Database	ID	URL or Descriptions
# AltName	VGLU2_HUMAN	Differentiation-associated BNPI
# AltName	VGLU2_HUMAN	Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter
# AltName	VGLU2_HUMAN	Solute carrier family 17 member 6
# CDD	cd06174	MFS
# DEVELOPMENTAL STAGE	Expressed in fetal brain. {ECO:0000269|PubMed	10820226}. 
# Ensembl	ENST00000263160	ENSP00000263160; ENSG00000091664
# FUNCTION	VGLU2_HUMAN	Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. {ECO 0000269|PubMed 10820226, ECO 0000269|PubMed 11698620}. 
# GO_component	GO:0016021	integral component of membrane; IBA:GO_Central.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030672	synaptic vesicle membrane; IBA:GO_Central.
# GO_component	GO:0043005	neuron projection; IEA:UniProtKB-SubCell.
# GO_function	GO:0005313	L-glutamate transmembrane transporter activity; IBA:GO_Central.
# GO_function	GO:0015293	symporter activity; IEA:UniProtKB-KW.
# GO_process	GO:0006811	ion transport; TAS:Reactome.
# GO_process	GO:0006814	sodium ion transport; IEA:UniProtKB-KW.
# GO_process	GO:0006836	neurotransmitter transport; IEA:UniProtKB-KW.
# GO_process	GO:0089711	L-glutamate transmembrane transport; IBA:GO_Central.
# GOslim_component	GO:0005575	cellular_component
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	Q9P2U8	HS
# HGNC	HGNC:16703	SLC17A6
# InterPro	IPR011701	MFS
# InterPro	IPR020846	MFS_dom
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Brite	ko02001	 Solute carrier family
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04724	Glutamatergic synapse
# KEGG_Pathway	ko05033	Nicotine addiction
# MIM	607563	gene
# Organism	VGLU2_HUMAN	Homo sapiens (Human)
# PROSITE	PS50850	MFS
# Pfam	PF07690	MFS_1
# Proteomes	UP000005640	Chromosome 11
# Reactome	R-HSA-428643	Organic anion transporters
# RecName	VGLU2_HUMAN	Vesicular glutamate transporter 2
# RefSeq	NP_065079	NM_020346.2
# SIMILARITY	Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	VGLU2_HUMAN	Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO 0000250|UniProtKB Q8BLE7}. Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. Cell junction, synapse, synaptosome {ECO 0000250|UniProtKB Q8BLE7}. 
# SUPFAM	SSF103473	SSF103473
# TCDB	2.A.1.14.31	the major facilitator superfamily (mfs)
# TISSUE SPECIFICITY	Predominantly expressed in adult brain. Expressed in amygdala, caudate nucleus, cerebral cortex, frontal lobe, hippocampus, medulla, occipital lobe, putamen, spinal cord, substantia nigra, subthalamic nucleus, temporal lobe and thalamus. {ECO:0000269|PubMed	10820226}. 
# UCSC	uc001mqk	human
# eggNOG	ENOG410XPWC	LUCA
# eggNOG	KOG2532	Eukaryota
BLAST	swissprot:VGLU2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VGLU2_HUMAN
BioCyc	ZFISH:ENSG00000091664-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000091664-MONOMER
COXPRESdb	57084	http://coxpresdb.jp/data/gene/57084.shtml
CleanEx	HS_SLC17A6	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_SLC17A6
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1046/j.1471-4159.2000.0742622.x	http://dx.doi.org/10.1046/j.1471-4159.2000.0742622.x
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
EMBL	AB032435	http://www.ebi.ac.uk/ena/data/view/AB032435
EMBL	AC040936	http://www.ebi.ac.uk/ena/data/view/AC040936
EMBL	BC069629	http://www.ebi.ac.uk/ena/data/view/BC069629
EMBL	BC069640	http://www.ebi.ac.uk/ena/data/view/BC069640
EMBL	BC069646	http://www.ebi.ac.uk/ena/data/view/BC069646
EMBL	CH471064	http://www.ebi.ac.uk/ena/data/view/CH471064
Ensembl	ENST00000263160	http://www.ensembl.org/id/ENST00000263160
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030672	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030672
GO_component	GO:0043005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043005
GO_function	GO:0005313	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005313
GO_function	GO:0015293	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293
GO_process	GO:0006811	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811
GO_process	GO:0006814	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814
GO_process	GO:0006836	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006836
GO_process	GO:0089711	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0089711
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	SLC17A6	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=SLC17A6
GeneID	57084	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57084
GeneTree	ENSGT00760000119079	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119079
HGNC	HGNC:16703	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:16703
HOGENOM	HOG000230812	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230812&db=HOGENOM6
HOVERGEN	HBG008834	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG008834&db=HOVERGEN
HPA	CAB037130	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB037130
HPA	HPA039226	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA039226
InParanoid	Q9P2U8	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9P2U8
InterPro	IPR011701	http://www.ebi.ac.uk/interpro/entry/IPR011701
InterPro	IPR020846	http://www.ebi.ac.uk/interpro/entry/IPR020846
Jabion	57084	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=57084
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Brite	ko02001	http://www.genome.jp/dbget-bin/www_bget?ko02001
KEGG_Gene	hsa:57084	http://www.genome.jp/dbget-bin/www_bget?hsa:57084
KEGG_Orthology	KO:K12302	http://www.genome.jp/dbget-bin/www_bget?KO:K12302
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
MIM	607563	http://www.ncbi.nlm.nih.gov/omim/607563
OMA	YNEQSQM	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YNEQSQM
OrthoDB	EOG091G06DG	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G06DG
PROSITE	PS50850	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850
PSORT	swissprot:VGLU2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VGLU2_HUMAN
PSORT-B	swissprot:VGLU2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VGLU2_HUMAN
PSORT2	swissprot:VGLU2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VGLU2_HUMAN
Pfam	PF07690	http://pfam.xfam.org/family/PF07690
PharmGKB	PA424	http://www.pharmgkb.org/do/serve?objId=PA424&objCls=Gene
Phobius	swissprot:VGLU2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VGLU2_HUMAN
PhylomeDB	Q9P2U8	http://phylomedb.org/?seqid=Q9P2U8
ProteinModelPortal	Q9P2U8	http://www.proteinmodelportal.org/query/uniprot/Q9P2U8
PubMed	10820226	http://www.ncbi.nlm.nih.gov/pubmed/10820226
PubMed	11698620	http://www.ncbi.nlm.nih.gov/pubmed/11698620
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
Reactome	R-HSA-428643	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428643
RefSeq	NP_065079	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_065079
STRING	9606.ENSP00000263160	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000263160&targetmode=cogs
SUPFAM	SSF103473	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473
TCDB	2.A.1.14.31	http://www.tcdb.org/search/result.php?tc=2.A.1.14.31
UCSC	uc001mqk	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001mqk&org=rat
UniGene	Hs.242821	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.242821
UniProtKB	VGLU2_HUMAN	http://www.uniprot.org/uniprot/VGLU2_HUMAN
UniProtKB-AC	Q9P2U8	http://www.uniprot.org/uniprot/Q9P2U8
charge	swissprot:VGLU2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VGLU2_HUMAN
eggNOG	ENOG410XPWC	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPWC
eggNOG	KOG2532	http://eggnogapi.embl.de/nog_data/html/tree/KOG2532
epestfind	swissprot:VGLU2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VGLU2_HUMAN
garnier	swissprot:VGLU2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VGLU2_HUMAN
helixturnhelix	swissprot:VGLU2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VGLU2_HUMAN
hmoment	swissprot:VGLU2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VGLU2_HUMAN
iep	swissprot:VGLU2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VGLU2_HUMAN
inforesidue	swissprot:VGLU2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VGLU2_HUMAN
neXtProt	NX_Q9P2U8	http://www.nextprot.org/db/entry/NX_Q9P2U8
octanol	swissprot:VGLU2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VGLU2_HUMAN
pepcoil	swissprot:VGLU2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VGLU2_HUMAN
pepdigest	swissprot:VGLU2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VGLU2_HUMAN
pepinfo	swissprot:VGLU2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VGLU2_HUMAN
pepnet	swissprot:VGLU2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VGLU2_HUMAN
pepstats	swissprot:VGLU2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VGLU2_HUMAN
pepwheel	swissprot:VGLU2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VGLU2_HUMAN
pepwindow	swissprot:VGLU2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VGLU2_HUMAN
sigcleave	swissprot:VGLU2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VGLU2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	PGAP2_HUMAN	Event=Alternative splicing; Named isoforms=5; Name=2; IsoId=Q9UHJ9-1; Sequence=Displayed; Name=1; IsoId=Q9UHJ9-2; Sequence=VSP_032550; Note=This isoform is predicted to contain an additional transmembrane domain at position 85-105. If this domain exists, the topology of the protein would be modified, possibly challenging the GPI-anchor remodeling function of the protein.; Name=3; IsoId=Q9UHJ9-3; Sequence=VSP_032551; Name=4; IsoId=Q9UHJ9-4; Sequence=VSP_045984, VSP_045985; Note=No experimental confirmation available.; Name=5; IsoId=Q9UHJ9-5; Sequence=VSP_053800, VSP_032551; Note=No experimental confirmation available.; 
# AltName	PGAP2_HUMAN	FGF receptor-activating protein 1
# BioGrid	118133	8
# CCDS	CCDS44523	-. [Q9UHJ9-5]
# CCDS	CCDS58112	-. [Q9UHJ9-1]
# CCDS	CCDS58113	-. [Q9UHJ9-4]
# CCDS	CCDS7747	-. [Q9UHJ9-2]
# ChiTaRS	PGAP2	human
# DISEASE	PGAP2_HUMAN	Hyperphosphatasia with mental retardation syndrome 3 (HPMRS3) [MIM 614207]  An autosomal recessive disorder usually characterized by mental retardation, hypotonia with very poor motor development, poor speech, and increased serum alkaline phosphatase. {ECO 0000269|PubMed 23561846, ECO 0000269|PubMed 23561847}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# Ensembl	ENST00000278243	ENSP00000278243; ENSG00000148985. [Q9UHJ9-2]
# Ensembl	ENST00000300730	ENSP00000300730; ENSG00000148985. [Q9UHJ9-5]
# Ensembl	ENST00000463452	ENSP00000435223; ENSG00000148985. [Q9UHJ9-1]
# Ensembl	ENST00000464906	ENSP00000434631; ENSG00000148985. [Q9UHJ9-2]
# Ensembl	ENST00000493547	ENSP00000431851; ENSG00000148985. [Q9UHJ9-4]
# ExpressionAtlas	Q9UHJ9	baseline and differential
# FUNCTION	PGAP2_HUMAN	Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity). {ECO 0000250}. 
# GO_component	GO:0000139	Golgi membrane; ISS:UniProtKB.
# GO_component	GO:0005634	nucleus; IEA:Ensembl.
# GO_component	GO:0005789	endoplasmic reticulum membrane; ISS:UniProtKB.
# GO_component	GO:0016021	integral component of membrane; TAS:ProtInc.
# GO_function	GO:0008565	protein transporter activity; ISS:UniProtKB.
# GO_process	GO:0006506	GPI anchor biosynthetic process; ISS:UniProtKB.
# GO_process	GO:0042770	signal transduction in response to DNA damage; IEA:Ensembl.
# GO_process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IEA:Ensembl.
# GO_process	GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005634	nucleus
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0006629	lipid metabolic process
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0009058	biosynthetic process
# Genevisible	Q9UHJ9	HS
# HGNC	HGNC:17893	PGAP2
# INTERACTION	PGAP2_HUMAN	P60411 KRTAP10-9; NbExp=3; IntAct=EBI-10321427, EBI-10172052; 
# IntAct	Q9UHJ9	10
# InterPro	IPR019402	Frag1/DRAM/Sfk1
# KEGG_Disease	H01488	[Inherited metabolic disease] Mabry syndrome
# KEGG_Disease	H01489:[Inherited metabolic disease] Hyperphosphatasia with mental retardation syndrome (HPMRS) [DS	H01488]
# MIM	614207	phenotype
# MIM	615187	gene
# Organism	PGAP2_HUMAN	Homo sapiens (Human)
# Orphanet	247262	Hyperphosphatasia-intellectual disability syndrome
# PIR	T12505	T12505
# Pfam	PF10277	Frag1
# Proteomes	UP000005640	Chromosome 11
# RecName	PGAP2_HUMAN	Post-GPI attachment to proteins factor 2
# RefSeq	NP_001138910	NM_001145438.2. [Q9UHJ9-5]
# RefSeq	NP_001243164	NM_001256235.1
# RefSeq	NP_001243165	NM_001256236.1
# RefSeq	NP_001243166	NM_001256237.1
# RefSeq	NP_001243167	NM_001256238.1. [Q9UHJ9-4]
# RefSeq	NP_001243168	NM_001256239.1. [Q9UHJ9-3]
# RefSeq	NP_001243169	NM_001256240.1. [Q9UHJ9-1]
# RefSeq	NP_001269967	NM_001283038.1
# RefSeq	NP_001269968	NM_001283039.1
# RefSeq	NP_001269969	NM_001283040.1
# RefSeq	NP_055304	NM_014489.3. [Q9UHJ9-2]
# RefSeq	XP_006718253	XM_006718190.3. [Q9UHJ9-1]
# RefSeq	XP_006718254	XM_006718191.3. [Q9UHJ9-3]
# RefSeq	XP_011518303	XM_011520001.1. [Q9UHJ9-1]
# RefSeq	XP_011518304	XM_011520002.1. [Q9UHJ9-3]
# RefSeq	XP_011518305	XM_011520003.2. [Q9UHJ9-2]
# RefSeq	XP_011518306	XM_011520004.2. [Q9UHJ9-2]
# SIMILARITY	Belongs to the PGAP2 family. {ECO	0000305}.
# SUBCELLULAR LOCATION	PGAP2_HUMAN	Golgi apparatus membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Endoplasmic reticulum membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. 
# SUBUNIT	Interacts with PGAP2IP. {ECO	0000250}. 
# TCDB	9.B.131.1	the post-gpi attachment protein (p-gap2) family
# TISSUE SPECIFICITY	Ubiquitously expressed, with highest levels in testis and pancreas. {ECO:0000269|PubMed	10585768}. 
# UCSC	uc001lys	human. [Q9UHJ9-1]
# eggNOG	ENOG410XT2T	LUCA
# eggNOG	KOG3979	Eukaryota
BLAST	swissprot:PGAP2_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:PGAP2_HUMAN
COXPRESdb	27315	http://coxpresdb.jp/data/gene/27315.shtml
DOI	10.1006/geno.1999.5980	http://dx.doi.org/10.1006/geno.1999.5980
DOI	10.1016/j.ajhg.2013.03.008	http://dx.doi.org/10.1016/j.ajhg.2013.03.008
DOI	10.1016/j.ajhg.2013.03.011	http://dx.doi.org/10.1016/j.ajhg.2013.03.011
DOI	10.1038/nature04632	http://dx.doi.org/10.1038/nature04632
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1186/1471-2164-8-399	http://dx.doi.org/10.1186/1471-2164-8-399
EMBL	AC090587	http://www.ebi.ac.uk/ena/data/view/AC090587
EMBL	AF159615	http://www.ebi.ac.uk/ena/data/view/AF159615
EMBL	AF159616	http://www.ebi.ac.uk/ena/data/view/AF159616
EMBL	AF159617	http://www.ebi.ac.uk/ena/data/view/AF159617
EMBL	AF159618	http://www.ebi.ac.uk/ena/data/view/AF159618
EMBL	AF159619	http://www.ebi.ac.uk/ena/data/view/AF159619
EMBL	AF159620	http://www.ebi.ac.uk/ena/data/view/AF159620
EMBL	AF159621	http://www.ebi.ac.uk/ena/data/view/AF159621
EMBL	AK292181	http://www.ebi.ac.uk/ena/data/view/AK292181
EMBL	AL096753	http://www.ebi.ac.uk/ena/data/view/AL096753
EMBL	AY373030	http://www.ebi.ac.uk/ena/data/view/AY373030
EMBL	BC009930	http://www.ebi.ac.uk/ena/data/view/BC009930
EMBL	BX379511	http://www.ebi.ac.uk/ena/data/view/BX379511
EMBL	CH471158	http://www.ebi.ac.uk/ena/data/view/CH471158
EMBL	CH471158	http://www.ebi.ac.uk/ena/data/view/CH471158
EMBL	CH471158	http://www.ebi.ac.uk/ena/data/view/CH471158
Ensembl	ENST00000278243	http://www.ensembl.org/id/ENST00000278243
Ensembl	ENST00000300730	http://www.ensembl.org/id/ENST00000300730
Ensembl	ENST00000463452	http://www.ensembl.org/id/ENST00000463452
Ensembl	ENST00000464906	http://www.ensembl.org/id/ENST00000464906
Ensembl	ENST00000493547	http://www.ensembl.org/id/ENST00000493547
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0000139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000139
GO_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_component	GO:0005789	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005789
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0006506	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006506
GO_process	GO:0042770	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042770
GO_process	GO:0042771	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042771
GO_process	GO:1902230	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902230
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005634	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0006629	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0009058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GeneCards	PGAP2	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=PGAP2
GeneID	27315	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27315
GeneTree	ENSGT00510000047299	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00510000047299
H-InvDB	HIX0009378	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0009378
HGNC	HGNC:17893	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:17893
HOGENOM	HOG000006821	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006821&db=HOGENOM6
HOVERGEN	HBG053417	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG053417&db=HOVERGEN
HPA	HPA063099	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA063099
InParanoid	Q9UHJ9	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UHJ9
IntAct	Q9UHJ9	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9UHJ9*
InterPro	IPR019402	http://www.ebi.ac.uk/interpro/entry/IPR019402
Jabion	27315	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=27315
KEGG_Disease	H01488	http://www.genome.jp/dbget-bin/www_bget?H01488
KEGG_Disease	H01489	http://www.genome.jp/dbget-bin/www_bget?H01489
KEGG_Gene	hsa:27315	http://www.genome.jp/dbget-bin/www_bget?hsa:27315
MIM	614207	http://www.ncbi.nlm.nih.gov/omim/614207
MIM	615187	http://www.ncbi.nlm.nih.gov/omim/615187
Orphanet	247262	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=247262
PSORT	swissprot:PGAP2_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:PGAP2_HUMAN
PSORT-B	swissprot:PGAP2_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:PGAP2_HUMAN
PSORT2	swissprot:PGAP2_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:PGAP2_HUMAN
Pfam	PF10277	http://pfam.xfam.org/family/PF10277
PharmGKB	PA165543520	http://www.pharmgkb.org/do/serve?objId=PA165543520&objCls=Gene
Phobius	swissprot:PGAP2_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:PGAP2_HUMAN
ProteinModelPortal	Q9UHJ9	http://www.proteinmodelportal.org/query/uniprot/Q9UHJ9
PubMed	10585768	http://www.ncbi.nlm.nih.gov/pubmed/10585768
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16554811	http://www.ncbi.nlm.nih.gov/pubmed/16554811
PubMed	17974005	http://www.ncbi.nlm.nih.gov/pubmed/17974005
PubMed	23561846	http://www.ncbi.nlm.nih.gov/pubmed/23561846
PubMed	23561847	http://www.ncbi.nlm.nih.gov/pubmed/23561847
RefSeq	NP_001138910	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001138910
RefSeq	NP_001243164	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243164
RefSeq	NP_001243165	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243165
RefSeq	NP_001243166	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243166
RefSeq	NP_001243167	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243167
RefSeq	NP_001243168	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243168
RefSeq	NP_001243169	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001243169
RefSeq	NP_001269967	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269967
RefSeq	NP_001269968	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269968
RefSeq	NP_001269969	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001269969
RefSeq	NP_055304	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055304
RefSeq	XP_006718253	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006718253
RefSeq	XP_006718254	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006718254
RefSeq	XP_011518303	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011518303
RefSeq	XP_011518304	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011518304
RefSeq	XP_011518305	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011518305
RefSeq	XP_011518306	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011518306
STRING	9606.ENSP00000278243	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000278243&targetmode=cogs
TCDB	9.B.131.1	http://www.tcdb.org/search/result.php?tc=9.B.131.1
UCSC	uc001lys	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001lys&org=rat
UniGene	Hs.133968	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.133968
UniProtKB	PGAP2_HUMAN	http://www.uniprot.org/uniprot/PGAP2_HUMAN
UniProtKB-AC	Q9UHJ9	http://www.uniprot.org/uniprot/Q9UHJ9
charge	swissprot:PGAP2_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:PGAP2_HUMAN
eggNOG	ENOG410XT2T	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XT2T
eggNOG	KOG3979	http://eggnogapi.embl.de/nog_data/html/tree/KOG3979
epestfind	swissprot:PGAP2_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:PGAP2_HUMAN
garnier	swissprot:PGAP2_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:PGAP2_HUMAN
helixturnhelix	swissprot:PGAP2_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:PGAP2_HUMAN
hmoment	swissprot:PGAP2_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:PGAP2_HUMAN
iep	swissprot:PGAP2_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:PGAP2_HUMAN
inforesidue	swissprot:PGAP2_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:PGAP2_HUMAN
neXtProt	NX_Q9UHJ9	http://www.nextprot.org/db/entry/NX_Q9UHJ9
octanol	swissprot:PGAP2_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:PGAP2_HUMAN
pepcoil	swissprot:PGAP2_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:PGAP2_HUMAN
pepdigest	swissprot:PGAP2_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:PGAP2_HUMAN
pepinfo	swissprot:PGAP2_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:PGAP2_HUMAN
pepnet	swissprot:PGAP2_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:PGAP2_HUMAN
pepstats	swissprot:PGAP2_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:PGAP2_HUMAN
pepwheel	swissprot:PGAP2_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:PGAP2_HUMAN
pepwindow	swissprot:PGAP2_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:PGAP2_HUMAN
sigcleave	swissprot:PGAP2_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:PGAP2_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	NMDE1_HUMAN	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q12879-1; Sequence=Displayed; Name=2; IsoId=Q12879-2; Sequence=VSP_044300; 
# AltName	NMDE1_HUMAN	Glutamate [NMDA] receptor subunit epsilon-1
# AltName	NMDE1_HUMAN	N-methyl D-aspartate receptor subtype 2A
# BioGrid	109160	16
# CCDS	CCDS10539	-. [Q12879-1]
# CCDS	CCDS45407	-. [Q12879-2]
# ChiTaRS	GRIN2A	human
# DISEASE	NMDE1_HUMAN	Epilepsy, focal, with speech disorder and with or without mental retardation (FESD) [MIM 245570]  A highly variable neurologic disorder with features ranging from severe early-onset seizures associated with delayed psychomotor development, persistent speech difficulties, and mental retardation to a more benign entity characterized by childhood onset of mild or asymptomatic seizures associated with transient speech difficulties followed by remission of seizures in adolescence and normal psychomotor development. The disorder encompasses several clinical entities, including Landau-Kleffner syndrome, epileptic encephalopathy with continuous spike and wave during slow-wave sleep, autosomal dominant rolandic epilepsy, mental retardation and speech dyspraxia, and benign epilepsy with centrotemporal spikes. {ECO 0000269|PubMed 20890276, ECO 0000269|PubMed 23033978, ECO 0000269|PubMed 23933818, ECO 0000269|PubMed 23933819, ECO 0000269|PubMed 23933820, ECO 0000269|PubMed 24504326, ECO 0000269|PubMed 24903190}. Note=The disease is caused by mutations affecting the gene represented in this entry. 
# DISEASE	NMDE1_HUMAN	Note=A chromosomal aberration involving GRIN2A has been found in a family with epilepsy and neurodevelopmental defects. Translocation t(16;17)(p13.2;q11.2). 
# DISEASE	NMDE1_HUMAN	Note=GRIN2A somatic mutations have been frequently found in cutaneous malignant melanoma, suggesting that the glutamate signaling pathway may play a role in the pathogenesis of melanoma. {ECO 0000269|PubMed 21499247, ECO 0000269|PubMed 24455489}. 
# DrugBank	DB00145	Glycine
# DrugBank	DB00289	Atomoxetine
# DrugBank	DB00312	Pentobarbital
# DrugBank	DB00418	Secobarbital
# DrugBank	DB00454	Pethidine
# DrugBank	DB00659	Acamprosate
# DrugBank	DB00949	Felbamate
# DrugBank	DB00996	Gabapentin
# DrugBank	DB01043	Memantine
# DrugBank	DB01159	Halothane
# DrugBank	DB01174	Phenobarbital
# DrugBank	DB04896	Milnacipran
# DrugBank	DB06151	Acetylcysteine
# DrugBank	DB06738	Ketobemidone
# Ensembl	ENST00000330684	ENSP00000332549; ENSG00000183454. [Q12879-1]
# Ensembl	ENST00000396573	ENSP00000379818; ENSG00000183454. [Q12879-1]
# Ensembl	ENST00000562109	ENSP00000454998; ENSG00000183454. [Q12879-2]
# ExpressionAtlas	Q12879	baseline and differential
# FUNCTION	NMDE1_HUMAN	NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits. 
# GO_component	GO:0005783	endoplasmic reticulum; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0008021	synaptic vesicle; IEA:Ensembl.
# GO_component	GO:0009986	cell surface; ISS:BHF-UCL.
# GO_component	GO:0014069	postsynaptic density; IEA:Ensembl.
# GO_component	GO:0017146	NMDA selective glutamate receptor complex; IDA:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0042734	presynaptic membrane; IEA:Ensembl.
# GO_component	GO:0043005	neuron projection; IEA:Ensembl.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_function	GO:0004972	NMDA glutamate receptor activity; TAS:ProtInc.
# GO_function	GO:0005088	Ras guanyl-nucleotide exchange factor activity; TAS:Reactome.
# GO_function	GO:0005234	extracellular-glutamate-gated ion channel activity; IEA:InterPro.
# GO_function	GO:0005262	calcium channel activity; IEA:Ensembl.
# GO_function	GO:0008270	zinc ion binding; ISS:UniProtKB.
# GO_process	GO:0000165	MAPK cascade; TAS:Reactome.
# GO_process	GO:0001964	startle response; IEA:Ensembl.
# GO_process	GO:0001975	response to amphetamine; IEA:Ensembl.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007215	glutamate receptor signaling pathway; TAS:ProtInc.
# GO_process	GO:0007268	chemical synaptic transmission; TAS:Reactome.
# GO_process	GO:0007611	learning or memory; TAS:ProtInc.
# GO_process	GO:0007613	memory; IEA:Ensembl.
# GO_process	GO:0008104	protein localization; IEA:Ensembl.
# GO_process	GO:0008542	visual learning; IEA:Ensembl.
# GO_process	GO:0009611	response to wounding; IEA:Ensembl.
# GO_process	GO:0019233	sensory perception of pain; IEA:Ensembl.
# GO_process	GO:0022008	neurogenesis; IEA:Ensembl.
# GO_process	GO:0030431	sleep; IEA:Ensembl.
# GO_process	GO:0033058	directional locomotion; IEA:Ensembl.
# GO_process	GO:0042177	negative regulation of protein catabolic process; IEA:Ensembl.
# GO_process	GO:0042417	dopamine metabolic process; IEA:Ensembl.
# GO_process	GO:0042428	serotonin metabolic process; IEA:Ensembl.
# GO_process	GO:0042493	response to drug; IEA:Ensembl.
# GO_process	GO:0043065	positive regulation of apoptotic process; IEA:Ensembl.
# GO_process	GO:0045471	response to ethanol; IDA:UniProtKB.
# GO_process	GO:0051930	regulation of sensory perception of pain; IEA:Ensembl.
# GO_process	GO:0060079	excitatory postsynaptic potential; IEA:Ensembl.
# GO_process	GO:0060291	long-term synaptic potentiation; IEA:Ensembl.
# GO_process	GO:1900273	positive regulation of long-term synaptic potentiation; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005783	endoplasmic reticulum
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0031410	cytoplasmic vesicle
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006464	cellular protein modification process
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0034641	cellular nitrogen compound metabolic process
# GOslim_process	GO:0040011	locomotion
# GOslim_process	GO:0050877	neurological system process
# Genevisible	Q12879	HS
# HGNC	HGNC:4585	GRIN2A
# INTERACTION	NMDE1_HUMAN	Q62936 Dlg3 (xeno); NbExp=5; IntAct=EBI-7249937, EBI-349596; P78352 DLG4; NbExp=3; IntAct=EBI-7249937, EBI-80389; P31016 Dlg4 (xeno); NbExp=2; IntAct=EBI-7249937, EBI-375655; 
# IntAct	Q12879	4
# InterPro	IPR001320	Iontro_rcpt
# InterPro	IPR001508	Iono_rcpt_met
# InterPro	IPR001828	ANF_lig-bd_rcpt
# InterPro	IPR018884	NMDAR2_C
# InterPro	IPR019594	Glu/Gly-bd
# InterPro	IPR028082	Peripla_BP_I
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Disease	H01514	[Nervous system disease; Epilepsy] Acquired epileptic aphasia
# KEGG_Pathway	ko04020	Calcium signaling pathway
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04713	Circadian entrainment
# KEGG_Pathway	ko04720	Long-term potentiation
# KEGG_Pathway	ko04724	Glutamatergic synapse
# KEGG_Pathway	ko04728	Dopaminergic synapse
# KEGG_Pathway	ko05010	Alzheimer's disease
# KEGG_Pathway	ko05014	Amyotrophic lateral sclerosis (ALS)
# KEGG_Pathway	ko05030	Cocaine addiction
# KEGG_Pathway	ko05031	Amphetamine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# KEGG_Pathway	ko05034	Alcoholism
# KEGG_Pathway	ko05322	Systemic lupus erythematosus
# MIM	138253	gene
# MIM	245570	phenotype
# Organism	NMDE1_HUMAN	Homo sapiens (Human)
# Orphanet	163721	Rolandic epilepsy - speech dyspraxia
# Orphanet	1945	Rolandic epilepsy
# Orphanet	289266	Early-onset epileptic encephalopathy and intellectual disability due to GRIN2A mutation
# Orphanet	725	Continuous spikes and waves during sleep
# Orphanet	98818	Landau-Kleffner syndrome
# PDB	3NFL	X-ray; 1.91 A; E/F/G/H=1449-1464
# PDB	5H8F	X-ray; 1.81 A; A=401-539, A=661-802
# PDB	5H8H	X-ray; 2.23 A; A=401-539, A=661-802
# PDB	5H8N	X-ray; 2.50 A; A=401-539, A=661-802
# PDB	5H8Q	X-ray; 1.90 A; A=401-539, A=661-802
# PDB	5I2K	X-ray; 2.86 A; A=401-539, A=661-802
# PDB	5I2N	X-ray; 2.12 A; A=401-539, A=661-802
# PDB	5KCJ	X-ray; 2.09 A; A=401-539, A=661-802
# PDB	5KDT	X-ray; 2.44 A; A=401-539, A=661-802
# PIR	S47555	S47555
# PRINTS	PR00177	NMDARECEPTOR
# Pfam	PF00060	Lig_chan
# Pfam	PF01094	ANF_receptor
# Pfam	PF10565	NMDAR2_C
# Pfam	PF10613	Lig_chan-Glu_bd
# Proteomes	UP000005640	Chromosome 16
# Reactome	R-HSA-438066	Unblocking of NMDA receptor, glutamate binding and activation
# Reactome	R-HSA-442729	CREB phosphorylation through the activation of CaMKII
# Reactome	R-HSA-442982	Ras activation uopn Ca2+ infux through NMDA receptor
# Reactome	R-HSA-5673001	RAF/MAP kinase cascade
# Reactome	R-HSA-6794361	Interactions of neurexins and neuroligins at synapses
# Reactome	R-HSA-8849932	SALM protein interactions at the synapses
# RecName	NMDE1_HUMAN	Glutamate receptor ionotropic, NMDA 2A
# RefSeq	NP_000824	NM_000833.4. [Q12879-1]
# RefSeq	NP_001127879	NM_001134407.2. [Q12879-1]
# RefSeq	NP_001127880	NM_001134408.2. [Q12879-2]
# RefSeq	XP_011520763	XM_011522461.2. [Q12879-2]
# SIMILARITY	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2A/GRIN2A subfamily. {ECO	0000305}.
# SMART	SM00079	PBPe
# SMART	SM00918	Lig_chan-Glu_bd
# SUBCELLULAR LOCATION	NMDE1_HUMAN	Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of AIP1, PATJ and DLG4. Interacts with HIP1 and NETO1 (By similarity). Interacts with LRFN2. Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes (By similarity). {ECO	0000250}. 
# SUPFAM	SSF53822	SSF53822
# UCSC	uc002czr	human. [Q12879-1]
# eggNOG	ENOG410XNUR	LUCA
# eggNOG	KOG1053	Eukaryota
BLAST	swissprot:NMDE1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:NMDE1_HUMAN
BioCyc	ZFISH:G66-32350-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-32350-MONOMER
COXPRESdb	2903	http://coxpresdb.jp/data/gene/2903.shtml
CleanEx	HS_GRIN2A	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GRIN2A
DIP	DIP-40798N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-40798N
DOI	10.1016/0167-4889(94)90086-8	http://dx.doi.org/10.1016/0167-4889(94)90086-8
DOI	10.1038/nature03187	http://dx.doi.org/10.1038/nature03187
DOI	10.1038/ncomms4251	http://dx.doi.org/10.1038/ncomms4251
DOI	10.1038/ng.2726	http://dx.doi.org/10.1038/ng.2726
DOI	10.1038/ng.2727	http://dx.doi.org/10.1038/ng.2727
DOI	10.1038/ng.2728	http://dx.doi.org/10.1038/ng.2728
DOI	10.1038/ng.677	http://dx.doi.org/10.1038/ng.677
DOI	10.1038/ng.810	http://dx.doi.org/10.1038/ng.810
DOI	10.1056/NEJMoa1206524	http://dx.doi.org/10.1056/NEJMoa1206524
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1111/epi.12663	http://dx.doi.org/10.1111/epi.12663
DOI	10.3389/fonc.2013.00333	http://dx.doi.org/10.3389/fonc.2013.00333
DrugBank	DB00145	http://www.drugbank.ca/drugs/DB00145
DrugBank	DB00289	http://www.drugbank.ca/drugs/DB00289
DrugBank	DB00312	http://www.drugbank.ca/drugs/DB00312
DrugBank	DB00418	http://www.drugbank.ca/drugs/DB00418
DrugBank	DB00454	http://www.drugbank.ca/drugs/DB00454
DrugBank	DB00659	http://www.drugbank.ca/drugs/DB00659
DrugBank	DB00949	http://www.drugbank.ca/drugs/DB00949
DrugBank	DB00996	http://www.drugbank.ca/drugs/DB00996
DrugBank	DB01043	http://www.drugbank.ca/drugs/DB01043
DrugBank	DB01159	http://www.drugbank.ca/drugs/DB01159
DrugBank	DB01174	http://www.drugbank.ca/drugs/DB01174
DrugBank	DB04896	http://www.drugbank.ca/drugs/DB04896
DrugBank	DB06151	http://www.drugbank.ca/drugs/DB06151
DrugBank	DB06738	http://www.drugbank.ca/drugs/DB06738
EMBL	AC006531	http://www.ebi.ac.uk/ena/data/view/AC006531
EMBL	AC007218	http://www.ebi.ac.uk/ena/data/view/AC007218
EMBL	AC022168	http://www.ebi.ac.uk/ena/data/view/AC022168
EMBL	AC026423	http://www.ebi.ac.uk/ena/data/view/AC026423
EMBL	AC133565	http://www.ebi.ac.uk/ena/data/view/AC133565
EMBL	BC117131	http://www.ebi.ac.uk/ena/data/view/BC117131
EMBL	BC143273	http://www.ebi.ac.uk/ena/data/view/BC143273
EMBL	U09002	http://www.ebi.ac.uk/ena/data/view/U09002
EMBL	U90277	http://www.ebi.ac.uk/ena/data/view/U90277
Ensembl	ENST00000330684	http://www.ensembl.org/id/ENST00000330684
Ensembl	ENST00000396573	http://www.ensembl.org/id/ENST00000396573
Ensembl	ENST00000562109	http://www.ensembl.org/id/ENST00000562109
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0008021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008021
GO_component	GO:0009986	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986
GO_component	GO:0014069	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014069
GO_component	GO:0017146	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017146
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0042734	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042734
GO_component	GO:0043005	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043005
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0004972	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004972
GO_function	GO:0005088	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005088
GO_function	GO:0005234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005234
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0008270	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270
GO_process	GO:0000165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000165
GO_process	GO:0001964	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001964
GO_process	GO:0001975	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001975
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007215
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007611	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007611
GO_process	GO:0007613	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007613
GO_process	GO:0008104	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008104
GO_process	GO:0008542	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008542
GO_process	GO:0009611	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009611
GO_process	GO:0019233	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019233
GO_process	GO:0022008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022008
GO_process	GO:0030431	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030431
GO_process	GO:0033058	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033058
GO_process	GO:0042177	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042177
GO_process	GO:0042417	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042417
GO_process	GO:0042428	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042428
GO_process	GO:0042493	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_process	GO:0043065	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043065
GO_process	GO:0045471	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045471
GO_process	GO:0051930	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051930
GO_process	GO:0060079	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060079
GO_process	GO:0060291	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060291
GO_process	GO:1900273	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900273
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005783	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0031410	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031410
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006464	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0034641	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_process	GO:0040011	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	GRIN2A	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GRIN2A
GeneID	2903	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2903
GeneTree	ENSGT00760000119186	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119186
HGNC	HGNC:4585	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4585
HOGENOM	HOG000113802	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000113802&db=HOGENOM6
HOVERGEN	HBG052635	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG052635&db=HOVERGEN
HPA	CAB022725	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB022725
InParanoid	Q12879	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q12879
IntAct	Q12879	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q12879*
InterPro	IPR001320	http://www.ebi.ac.uk/interpro/entry/IPR001320
InterPro	IPR001508	http://www.ebi.ac.uk/interpro/entry/IPR001508
InterPro	IPR001828	http://www.ebi.ac.uk/interpro/entry/IPR001828
InterPro	IPR018884	http://www.ebi.ac.uk/interpro/entry/IPR018884
InterPro	IPR019594	http://www.ebi.ac.uk/interpro/entry/IPR019594
InterPro	IPR028082	http://www.ebi.ac.uk/interpro/entry/IPR028082
Jabion	2903	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2903
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Disease	H01514	http://www.genome.jp/dbget-bin/www_bget?H01514
KEGG_Gene	hsa:2903	http://www.genome.jp/dbget-bin/www_bget?hsa:2903
KEGG_Orthology	KO:K05209	http://www.genome.jp/dbget-bin/www_bget?KO:K05209
KEGG_Pathway	ko04020	http://www.genome.jp/kegg-bin/show_pathway?ko04020
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04713	http://www.genome.jp/kegg-bin/show_pathway?ko04713
KEGG_Pathway	ko04720	http://www.genome.jp/kegg-bin/show_pathway?ko04720
KEGG_Pathway	ko04724	http://www.genome.jp/kegg-bin/show_pathway?ko04724
KEGG_Pathway	ko04728	http://www.genome.jp/kegg-bin/show_pathway?ko04728
KEGG_Pathway	ko05010	http://www.genome.jp/kegg-bin/show_pathway?ko05010
KEGG_Pathway	ko05014	http://www.genome.jp/kegg-bin/show_pathway?ko05014
KEGG_Pathway	ko05030	http://www.genome.jp/kegg-bin/show_pathway?ko05030
KEGG_Pathway	ko05031	http://www.genome.jp/kegg-bin/show_pathway?ko05031
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
KEGG_Pathway	ko05034	http://www.genome.jp/kegg-bin/show_pathway?ko05034
KEGG_Pathway	ko05322	http://www.genome.jp/kegg-bin/show_pathway?ko05322
MIM	138253	http://www.ncbi.nlm.nih.gov/omim/138253
MIM	245570	http://www.ncbi.nlm.nih.gov/omim/245570
MINT	MINT-414776	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-414776
OMA	WEYPLET	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WEYPLET
Orphanet	163721	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=163721
Orphanet	1945	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1945
Orphanet	289266	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=289266
Orphanet	725	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=725
Orphanet	98818	http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=98818
OrthoDB	EOG091G09KH	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G09KH
PDB	3NFL	http://www.ebi.ac.uk/pdbe-srv/view/entry/3NFL
PDB	5H8F	http://www.ebi.ac.uk/pdbe-srv/view/entry/5H8F
PDB	5H8H	http://www.ebi.ac.uk/pdbe-srv/view/entry/5H8H
PDB	5H8N	http://www.ebi.ac.uk/pdbe-srv/view/entry/5H8N
PDB	5H8Q	http://www.ebi.ac.uk/pdbe-srv/view/entry/5H8Q
PDB	5I2K	http://www.ebi.ac.uk/pdbe-srv/view/entry/5I2K
PDB	5I2N	http://www.ebi.ac.uk/pdbe-srv/view/entry/5I2N
PDB	5KCJ	http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCJ
PDB	5KDT	http://www.ebi.ac.uk/pdbe-srv/view/entry/5KDT
PDBsum	3NFL	http://www.ebi.ac.uk/pdbsum/3NFL
PDBsum	5H8F	http://www.ebi.ac.uk/pdbsum/5H8F
PDBsum	5H8H	http://www.ebi.ac.uk/pdbsum/5H8H
PDBsum	5H8N	http://www.ebi.ac.uk/pdbsum/5H8N
PDBsum	5H8Q	http://www.ebi.ac.uk/pdbsum/5H8Q
PDBsum	5I2K	http://www.ebi.ac.uk/pdbsum/5I2K
PDBsum	5I2N	http://www.ebi.ac.uk/pdbsum/5I2N
PDBsum	5KCJ	http://www.ebi.ac.uk/pdbsum/5KCJ
PDBsum	5KDT	http://www.ebi.ac.uk/pdbsum/5KDT
PRINTS	PR00177	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00177
PSORT	swissprot:NMDE1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:NMDE1_HUMAN
PSORT-B	swissprot:NMDE1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:NMDE1_HUMAN
PSORT2	swissprot:NMDE1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:NMDE1_HUMAN
Pfam	PF00060	http://pfam.xfam.org/family/PF00060
Pfam	PF01094	http://pfam.xfam.org/family/PF01094
Pfam	PF10565	http://pfam.xfam.org/family/PF10565
Pfam	PF10613	http://pfam.xfam.org/family/PF10613
PharmGKB	PA28979	http://www.pharmgkb.org/do/serve?objId=PA28979&objCls=Gene
Phobius	swissprot:NMDE1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:NMDE1_HUMAN
PhylomeDB	Q12879	http://phylomedb.org/?seqid=Q12879
ProteinModelPortal	Q12879	http://www.proteinmodelportal.org/query/uniprot/Q12879
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15616553	http://www.ncbi.nlm.nih.gov/pubmed/15616553
PubMed	20890276	http://www.ncbi.nlm.nih.gov/pubmed/20890276
PubMed	21499247	http://www.ncbi.nlm.nih.gov/pubmed/21499247
PubMed	23033978	http://www.ncbi.nlm.nih.gov/pubmed/23033978
PubMed	23933818	http://www.ncbi.nlm.nih.gov/pubmed/23933818
PubMed	23933819	http://www.ncbi.nlm.nih.gov/pubmed/23933819
PubMed	23933820	http://www.ncbi.nlm.nih.gov/pubmed/23933820
PubMed	24455489	http://www.ncbi.nlm.nih.gov/pubmed/24455489
PubMed	24504326	http://www.ncbi.nlm.nih.gov/pubmed/24504326
PubMed	24903190	http://www.ncbi.nlm.nih.gov/pubmed/24903190
PubMed	8061049	http://www.ncbi.nlm.nih.gov/pubmed/8061049
PubMed	8768735	http://www.ncbi.nlm.nih.gov/pubmed/8768735
Reactome	R-HSA-438066	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-438066
Reactome	R-HSA-442729	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442729
Reactome	R-HSA-442982	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-442982
Reactome	R-HSA-5673001	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5673001
Reactome	R-HSA-6794361	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6794361
Reactome	R-HSA-8849932	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8849932
RefSeq	NP_000824	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000824
RefSeq	NP_001127879	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001127879
RefSeq	NP_001127880	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001127880
RefSeq	XP_011520763	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_011520763
SMART	SM00079	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00079
SMART	SM00918	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00918
SMR	Q12879	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q12879
STRING	9606.ENSP00000332549	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000332549&targetmode=cogs
SUPFAM	SSF53822	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822
UCSC	uc002czr	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002czr&org=rat
UniGene	Hs.411472	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.411472
UniProtKB	NMDE1_HUMAN	http://www.uniprot.org/uniprot/NMDE1_HUMAN
UniProtKB-AC	Q12879	http://www.uniprot.org/uniprot/Q12879
charge	swissprot:NMDE1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:NMDE1_HUMAN
eggNOG	ENOG410XNUR	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNUR
eggNOG	KOG1053	http://eggnogapi.embl.de/nog_data/html/tree/KOG1053
epestfind	swissprot:NMDE1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:NMDE1_HUMAN
garnier	swissprot:NMDE1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:NMDE1_HUMAN
helixturnhelix	swissprot:NMDE1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:NMDE1_HUMAN
hmoment	swissprot:NMDE1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:NMDE1_HUMAN
iep	swissprot:NMDE1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:NMDE1_HUMAN
inforesidue	swissprot:NMDE1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:NMDE1_HUMAN
neXtProt	NX_Q12879	http://www.nextprot.org/db/entry/NX_Q12879
octanol	swissprot:NMDE1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:NMDE1_HUMAN
pepcoil	swissprot:NMDE1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:NMDE1_HUMAN
pepdigest	swissprot:NMDE1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:NMDE1_HUMAN
pepinfo	swissprot:NMDE1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:NMDE1_HUMAN
pepnet	swissprot:NMDE1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:NMDE1_HUMAN
pepstats	swissprot:NMDE1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:NMDE1_HUMAN
pepwheel	swissprot:NMDE1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:NMDE1_HUMAN
pepwindow	swissprot:NMDE1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:NMDE1_HUMAN
sigcleave	swissprot:NMDE1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:NMDE1_HUMAN
## Database	ID	URL or Descriptions
# AltName	VA0E1_HUMAN	V-ATPase 9.2 kDa membrane accessory protein
# AltName	VA0E1_HUMAN	V-ATPase M9.2 subunit
# AltName	VA0E1_HUMAN	Vacuolar proton pump subunit e 1
# BioGrid	114473	10
# ChiTaRS	ATP6V0E1	human
# Ensembl	ENST00000517669	ENSP00000427941; ENSG00000113732
# Ensembl	ENST00000519374	ENSP00000429690; ENSG00000113732
# ExpressionAtlas	O15342	baseline and differential
# FUNCTION	VA0E1_HUMAN	Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. 
# GO_component	GO:0010008	endosome membrane; TAS:Reactome.
# GO_component	GO:0016020	membrane; TAS:ProtInc.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_component	GO:0030670	phagocytic vesicle membrane; TAS:Reactome.
# GO_component	GO:0033179	proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
# GO_function	GO:0005215	transporter activity; NAS:ProtInc.
# GO_function	GO:0042625	ATPase coupled ion transmembrane transporter activity; ISS:UniProtKB.
# GO_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism; TAS:ProtInc.
# GO_process	GO:0007035	vacuolar acidification; ISS:UniProtKB.
# GO_process	GO:0008286	insulin receptor signaling pathway; TAS:Reactome.
# GO_process	GO:0015991	ATP hydrolysis coupled proton transport; IEA:InterPro.
# GO_process	GO:0015992	proton transport; TAS:ProtInc.
# GO_process	GO:0016049	cell growth; IGI:UniProtKB.
# GO_process	GO:0016241	regulation of macroautophagy; NAS:ParkinsonsUK-UCL.
# GO_process	GO:0033572	transferrin transport; TAS:Reactome.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0090383	phagosome acidification; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0040007	growth
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0055085	transmembrane transport
# Genevisible	O15342	HS
# HGNC	HGNC:863	ATP6V0E1
# InterPro	IPR008389	ATPase_V0-cplx_e1/e2_su
# InterPro	IPR017385	ATPase_V0-cplx_e1/e2_su_met
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko00002	 KEGG pathway modules
# KEGG_Brite	ko01000	 Enzymes
# KEGG_Pathway	ko00190	Oxidative phosphorylation
# KEGG_Pathway	ko04145	Phagosome
# KEGG_Pathway	ko04721	Synaptic vesicle cycle
# KEGG_Pathway	ko04966	Collecting duct acid secretion
# KEGG_Pathway	ko05110	Vibrio cholerae infection
# KEGG_Pathway	ko05120	Epithelial cell signaling in Helicobacter pylori infection
# KEGG_Pathway	ko05323	Rheumatoid arthritis
# MIM	603931	gene
# Organism	VA0E1_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR12263	PTHR12263
# PIRSF	PIRSF038097	V-ATP_synth_e1/e2
# Pfam	PF05493	ATP_synt_H
# Proteomes	UP000005640	Chromosome 5
# Reactome	R-HSA-1222556	ROS, RNS production in response to bacteria
# Reactome	R-HSA-77387	Insulin receptor recycling
# Reactome	R-HSA-917977	Transferrin endocytosis and recycling
# Reactome	R-HSA-983712	Ion channel transport
# RecName	VA0E1_HUMAN	V-type proton ATPase subunit e 1
# RefSeq	NP_003936	NM_003945.3
# SEQUENCE CAUTION	Sequence=CAA75571.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the V-ATPase e1/e2 subunit family. {ECO	0000305}. 
# SUBCELLULAR LOCATION	VA0E1_HUMAN	Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUBUNIT	VA0E1_HUMAN	Composed of at least 10 subunits. 
# TISSUE SPECIFICITY	Ubiquitous. {ECO:0000269|PubMed	17350184}. 
# UCSC	uc003mcd	human
# eggNOG	ENOG41121M0	LUCA
# eggNOG	KOG3500	Eukaryota
BLAST	swissprot:VA0E1_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:VA0E1_HUMAN
BioCyc	MetaCyc:HS03712-MONOMER	http://biocyc.org/getid?id=MetaCyc:HS03712-MONOMER
BioCyc	ZFISH:HS03712-MONOMER	http://biocyc.org/getid?id=ZFISH:HS03712-MONOMER
COXPRESdb	8992	http://coxpresdb.jp/data/gene/8992.shtml
CleanEx	HS_ATP6V0E1	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ATP6V0E1
DOI	10.1016/j.gene.2007.01.020	http://dx.doi.org/10.1016/j.gene.2007.01.020
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.273.18.10939	http://dx.doi.org/10.1074/jbc.273.18.10939
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AK312068	http://www.ebi.ac.uk/ena/data/view/AK312068
EMBL	BC119714	http://www.ebi.ac.uk/ena/data/view/BC119714
EMBL	BC119715	http://www.ebi.ac.uk/ena/data/view/BC119715
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	CH471062	http://www.ebi.ac.uk/ena/data/view/CH471062
EMBL	CR456856	http://www.ebi.ac.uk/ena/data/view/CR456856
EMBL	CR542131	http://www.ebi.ac.uk/ena/data/view/CR542131
EMBL	Y15286	http://www.ebi.ac.uk/ena/data/view/Y15286
Ensembl	ENST00000517669	http://www.ensembl.org/id/ENST00000517669
Ensembl	ENST00000519374	http://www.ensembl.org/id/ENST00000519374
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0010008	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010008
GO_component	GO:0016020	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_component	GO:0030670	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030670
GO_component	GO:0033179	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033179
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0042625	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042625
GO_function	GO:0046961	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046961
GO_process	GO:0007035	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007035
GO_process	GO:0008286	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008286
GO_process	GO:0015991	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015991
GO_process	GO:0015992	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992
GO_process	GO:0016049	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016049
GO_process	GO:0016241	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016241
GO_process	GO:0033572	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033572
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0090383	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090383
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0040007	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040007
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GeneCards	ATP6V0E1	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATP6V0E1
GeneID	8992	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8992
GeneTree	ENSGT00390000000728	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00390000000728
HGNC	HGNC:863	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:863
HOGENOM	HOG000265078	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265078&db=HOGENOM6
HOVERGEN	HBG003974	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG003974&db=HOVERGEN
InParanoid	O15342	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O15342
InterPro	IPR008389	http://www.ebi.ac.uk/interpro/entry/IPR008389
InterPro	IPR017385	http://www.ebi.ac.uk/interpro/entry/IPR017385
Jabion	8992	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=8992
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko00002	http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Brite	ko01000	http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Gene	hsa:8992	http://www.genome.jp/dbget-bin/www_bget?hsa:8992
KEGG_Orthology	KO:K02153	http://www.genome.jp/dbget-bin/www_bget?KO:K02153
KEGG_Pathway	ko00190	http://www.genome.jp/kegg-bin/show_pathway?ko00190
KEGG_Pathway	ko04145	http://www.genome.jp/kegg-bin/show_pathway?ko04145
KEGG_Pathway	ko04721	http://www.genome.jp/kegg-bin/show_pathway?ko04721
KEGG_Pathway	ko04966	http://www.genome.jp/kegg-bin/show_pathway?ko04966
KEGG_Pathway	ko05110	http://www.genome.jp/kegg-bin/show_pathway?ko05110
KEGG_Pathway	ko05120	http://www.genome.jp/kegg-bin/show_pathway?ko05120
KEGG_Pathway	ko05323	http://www.genome.jp/kegg-bin/show_pathway?ko05323
MIM	603931	http://www.ncbi.nlm.nih.gov/omim/603931
OMA	GVVPWFI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GVVPWFI
OrthoDB	EOG091G113P	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G113P
PANTHER	PTHR12263	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12263
PSORT	swissprot:VA0E1_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:VA0E1_HUMAN
PSORT-B	swissprot:VA0E1_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:VA0E1_HUMAN
PSORT2	swissprot:VA0E1_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:VA0E1_HUMAN
Pfam	PF05493	http://pfam.xfam.org/family/PF05493
PharmGKB	PA25151	http://www.pharmgkb.org/do/serve?objId=PA25151&objCls=Gene
Phobius	swissprot:VA0E1_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:VA0E1_HUMAN
PhylomeDB	O15342	http://phylomedb.org/?seqid=O15342
ProteinModelPortal	O15342	http://www.proteinmodelportal.org/query/uniprot/O15342
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17350184	http://www.ncbi.nlm.nih.gov/pubmed/17350184
PubMed	9556572	http://www.ncbi.nlm.nih.gov/pubmed/9556572
Reactome	R-HSA-1222556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1222556
Reactome	R-HSA-77387	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-77387
Reactome	R-HSA-917977	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-917977
Reactome	R-HSA-983712	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983712
RefSeq	NP_003936	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_003936
STRING	9606.ENSP00000427941	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000427941&targetmode=cogs
UCSC	uc003mcd	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003mcd&org=rat
UniGene	Hs.484188	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.484188
UniProtKB	VA0E1_HUMAN	http://www.uniprot.org/uniprot/VA0E1_HUMAN
UniProtKB-AC	O15342	http://www.uniprot.org/uniprot/O15342
charge	swissprot:VA0E1_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:VA0E1_HUMAN
eggNOG	ENOG41121M0	http://eggnogapi.embl.de/nog_data/html/tree/ENOG41121M0
eggNOG	KOG3500	http://eggnogapi.embl.de/nog_data/html/tree/KOG3500
epestfind	swissprot:VA0E1_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:VA0E1_HUMAN
garnier	swissprot:VA0E1_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:VA0E1_HUMAN
helixturnhelix	swissprot:VA0E1_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:VA0E1_HUMAN
hmoment	swissprot:VA0E1_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:VA0E1_HUMAN
iep	swissprot:VA0E1_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:VA0E1_HUMAN
inforesidue	swissprot:VA0E1_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:VA0E1_HUMAN
neXtProt	NX_O15342	http://www.nextprot.org/db/entry/NX_O15342
octanol	swissprot:VA0E1_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:VA0E1_HUMAN
pepcoil	swissprot:VA0E1_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:VA0E1_HUMAN
pepdigest	swissprot:VA0E1_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:VA0E1_HUMAN
pepinfo	swissprot:VA0E1_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:VA0E1_HUMAN
pepnet	swissprot:VA0E1_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:VA0E1_HUMAN
pepstats	swissprot:VA0E1_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:VA0E1_HUMAN
pepwheel	swissprot:VA0E1_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:VA0E1_HUMAN
pepwindow	swissprot:VA0E1_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:VA0E1_HUMAN
sigcleave	swissprot:VA0E1_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:VA0E1_HUMAN
## Database	ID	URL or Descriptions
# AltName	IMA6_HUMAN	Karyopherin subunit alpha-5
# BioGrid	110039	25
# ChiTaRS	KPNA5	human
# DOMAIN	IMA6_HUMAN	Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import. 
# DOMAIN	IMA6_HUMAN	The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS- containing proteins (By similarity). {ECO 0000250}. 
# DOMAIN	IMA6_HUMAN	The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity). {ECO 0000250}. 
# Ensembl	ENST00000356348	ENSP00000348704; ENSG00000196911
# Ensembl	ENST00000368564	ENSP00000357552; ENSG00000196911
# ExpressionAtlas	O15131	baseline and differential
# FUNCTION	IMA6_HUMAN	Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non- classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. 
# GO_component	GO:0005643	nuclear pore; IBA:GO_Central.
# GO_component	GO:0005654	nucleoplasm; IBA:GO_Central.
# GO_component	GO:0005737	cytoplasm; IDA:HPA.
# GO_component	GO:0005829	cytosol; IBA:GO_Central.
# GO_function	GO:0008139	nuclear localization sequence binding; IBA:GO_Central.
# GO_function	GO:0008565	protein transporter activity; IBA:GO_Central.
# GO_process	GO:0006607	NLS-bearing protein import into nucleus; TAS:ProtInc.
# GO_process	GO:0019054	modulation by virus of host process; TAS:Reactome.
# GO_process	GO:0075733	intracellular transport of virus; TAS:Reactome.
# GOslim_component	GO:0005654	nucleoplasm
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005829	cytosol
# GOslim_component	GO:0043234	protein complex
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0008565	protein transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006913	nucleocytoplasmic transport
# GOslim_process	GO:0044403	symbiosis, encompassing mutualism through parasitism
# Gene3D	1.25.10.10	-; 1.
# Genevisible	O15131	HS
# HGNC	HGNC:6398	KPNA5
# INTERACTION	IMA6_HUMAN	Q92688 ANP32B; NbExp=3; IntAct=EBI-540602, EBI-762428; P46527 CDKN1B; NbExp=6; IntAct=EBI-540602, EBI-519280; Q9UKX7 NUP50; NbExp=3; IntAct=EBI-540602, EBI-2371082; Q6IQ16 SPOPL; NbExp=3; IntAct=EBI-540602, EBI-2822161; 
# IntAct	O15131	13
# InterPro	IPR000225	Armadillo
# InterPro	IPR002652	Importin-a_IBB
# InterPro	IPR011989	ARM-like
# InterPro	IPR016024	ARM-type_fold
# InterPro	IPR024931	Importing_su_alpha
# InterPro	IPR032413	Arm_3
# MIM	604545	gene
# Organism	IMA6_HUMAN	Homo sapiens (Human)
# PDB	4U2X	X-ray; 3.15 A; D/E/F=329-503
# PIRSF	PIRSF005673	Importin_alpha
# PROSITE	PS50176	ARM_REPEAT; 2
# PROSITE	PS51214	IBB
# Pfam	PF00514	Arm; 8
# Pfam	PF01749	IBB
# Pfam	PF16186	Arm_3
# Proteomes	UP000005640	Chromosome 6
# Reactome	R-HSA-1169408	ISG15 antiviral mechanism
# Reactome	R-HSA-168276	NS1 Mediated Effects on Host Pathways
# RecName	IMA6_HUMAN	Importin subunit alpha-6
# RefSeq	NP_002260	NM_002269.2
# RefSeq	XP_016866328	XM_017010839.1
# RefSeq	XP_016866329	XM_017010840.1
# SEQUENCE CAUTION	Sequence=AAH47409.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI20500.1; Type=Erroneous initiation; Evidence={ECO	0000305};
# SIMILARITY	Belongs to the importin alpha family. {ECO	0000305}. 
# SIMILARITY	Contains 1 IBB domain. {ECO:0000255|PROSITE- ProRule	PRU00561}. 
# SIMILARITY	Contains 10 ARM repeats. {ECO:0000255|PROSITE- ProRule	PRU00259}. 
# SMART	SM00185	ARM; 8
# SUBCELLULAR LOCATION	IMA6_HUMAN	Cytoplasm. 
# SUBUNIT	IMA6_HUMAN	Forms a complex with importin subunit beta-1. 
# SUPFAM	SSF48371	SSF48371
# TCDB	1.I.1.1	the nuclear pore complex (npc) family
# TISSUE SPECIFICITY	IMA6_HUMAN	Testis. 
# UCSC	uc003pxh	human
# eggNOG	COG5064	LUCA
# eggNOG	KOG0166	Eukaryota
BLAST	swissprot:IMA6_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:IMA6_HUMAN
BioCyc	ZFISH:G66-30800-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-30800-MONOMER
COXPRESdb	3841	http://coxpresdb.jp/data/gene/3841.shtml
CleanEx	HS_KPNA5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_KPNA5
DIP	DIP-33405N	http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-33405N
DOI	10.1016/S0014-5793(97)01265-9	http://dx.doi.org/10.1016/S0014-5793(97)01265-9
DOI	10.1038/nature02055	http://dx.doi.org/10.1038/nature02055
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1074/jbc.M303571200	http://dx.doi.org/10.1074/jbc.M303571200
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1126/science.1133427	http://dx.doi.org/10.1126/science.1133427
DOI	10.1128/JVI.77.6.3734-3748.2003	http://dx.doi.org/10.1128/JVI.77.6.3734-3748.2003
DOI	10.1186/1752-0509-5-17	http://dx.doi.org/10.1186/1752-0509-5-17
EMBL	AF005361	http://www.ebi.ac.uk/ena/data/view/AF005361
EMBL	AK314206	http://www.ebi.ac.uk/ena/data/view/AK314206
EMBL	AL132795	http://www.ebi.ac.uk/ena/data/view/AL132795
EMBL	BC047409	http://www.ebi.ac.uk/ena/data/view/BC047409
EMBL	CH471051	http://www.ebi.ac.uk/ena/data/view/CH471051
Ensembl	ENST00000356348	http://www.ensembl.org/id/ENST00000356348
Ensembl	ENST00000368564	http://www.ensembl.org/id/ENST00000368564
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005643	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005643
GO_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_function	GO:0008139	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008139
GO_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GO_process	GO:0006607	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006607
GO_process	GO:0019054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019054
GO_process	GO:0075733	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0075733
GOslim_component	GO:0005654	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005829	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_component	GO:0043234	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0008565	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006913	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006913
GOslim_process	GO:0044403	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403
Gene3D	1.25.10.10	http://www.cathdb.info/version/latest/superfamily/1.25.10.10
GeneCards	KPNA5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KPNA5
GeneID	3841	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3841
HGNC	HGNC:6398	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:6398
HOGENOM	HOG000167616	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000167616&db=HOGENOM6
HOVERGEN	HBG001846	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG001846&db=HOVERGEN
HPA	CAB026464	http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB026464
HPA	HPA054037	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA054037
InParanoid	O15131	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O15131
IntAct	O15131	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O15131*
InterPro	IPR000225	http://www.ebi.ac.uk/interpro/entry/IPR000225
InterPro	IPR002652	http://www.ebi.ac.uk/interpro/entry/IPR002652
InterPro	IPR011989	http://www.ebi.ac.uk/interpro/entry/IPR011989
InterPro	IPR016024	http://www.ebi.ac.uk/interpro/entry/IPR016024
InterPro	IPR024931	http://www.ebi.ac.uk/interpro/entry/IPR024931
InterPro	IPR032413	http://www.ebi.ac.uk/interpro/entry/IPR032413
Jabion	3841	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=3841
KEGG_Gene	hsa:3841	http://www.genome.jp/dbget-bin/www_bget?hsa:3841
MIM	604545	http://www.ncbi.nlm.nih.gov/omim/604545
MINT	MINT-2860255	http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-2860255
OrthoDB	EOG091G095Z	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G095Z
PDB	4U2X	http://www.ebi.ac.uk/pdbe-srv/view/entry/4U2X
PDBsum	4U2X	http://www.ebi.ac.uk/pdbsum/4U2X
PROSITE	PS50176	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50176
PROSITE	PS51214	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51214
PSORT	swissprot:IMA6_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:IMA6_HUMAN
PSORT-B	swissprot:IMA6_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:IMA6_HUMAN
PSORT2	swissprot:IMA6_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:IMA6_HUMAN
Pfam	PF00514	http://pfam.xfam.org/family/PF00514
Pfam	PF01749	http://pfam.xfam.org/family/PF01749
Pfam	PF16186	http://pfam.xfam.org/family/PF16186
PharmGKB	PA30189	http://www.pharmgkb.org/do/serve?objId=PA30189&objCls=Gene
Phobius	swissprot:IMA6_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:IMA6_HUMAN
PhylomeDB	O15131	http://phylomedb.org/?seqid=O15131
ProteinModelPortal	O15131	http://www.proteinmodelportal.org/query/uniprot/O15131
PubMed	12610148	http://www.ncbi.nlm.nih.gov/pubmed/12610148
PubMed	12740372	http://www.ncbi.nlm.nih.gov/pubmed/12740372
PubMed	14574404	http://www.ncbi.nlm.nih.gov/pubmed/14574404
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16959974	http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed	21269460	http://www.ncbi.nlm.nih.gov/pubmed/21269460
PubMed	9395085	http://www.ncbi.nlm.nih.gov/pubmed/9395085
Reactome	R-HSA-1169408	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1169408
Reactome	R-HSA-168276	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-168276
RefSeq	NP_002260	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_002260
RefSeq	XP_016866328	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016866328
RefSeq	XP_016866329	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016866329
SMART	SM00185	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00185
SMR	O15131	http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O15131
STRING	9606.ENSP00000348704	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000348704&targetmode=cogs
SUPFAM	SSF48371	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371
TCDB	1.I.1.1	http://www.tcdb.org/search/result.php?tc=1.I.1.1
UCSC	uc003pxh	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003pxh&org=rat
UniGene	Hs.182971	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.182971
UniProtKB	IMA6_HUMAN	http://www.uniprot.org/uniprot/IMA6_HUMAN
UniProtKB-AC	O15131	http://www.uniprot.org/uniprot/O15131
charge	swissprot:IMA6_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:IMA6_HUMAN
eggNOG	COG5064	http://eggnogapi.embl.de/nog_data/html/tree/COG5064
eggNOG	KOG0166	http://eggnogapi.embl.de/nog_data/html/tree/KOG0166
epestfind	swissprot:IMA6_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:IMA6_HUMAN
garnier	swissprot:IMA6_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:IMA6_HUMAN
helixturnhelix	swissprot:IMA6_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:IMA6_HUMAN
hmoment	swissprot:IMA6_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:IMA6_HUMAN
iep	swissprot:IMA6_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:IMA6_HUMAN
inforesidue	swissprot:IMA6_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:IMA6_HUMAN
neXtProt	NX_O15131	http://www.nextprot.org/db/entry/NX_O15131
octanol	swissprot:IMA6_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:IMA6_HUMAN
pepcoil	swissprot:IMA6_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:IMA6_HUMAN
pepdigest	swissprot:IMA6_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:IMA6_HUMAN
pepinfo	swissprot:IMA6_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:IMA6_HUMAN
pepnet	swissprot:IMA6_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:IMA6_HUMAN
pepstats	swissprot:IMA6_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:IMA6_HUMAN
pepwheel	swissprot:IMA6_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:IMA6_HUMAN
pepwindow	swissprot:IMA6_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:IMA6_HUMAN
sigcleave	swissprot:IMA6_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:IMA6_HUMAN
## Database	ID	URL or Descriptions
# AltName	TRPC5_HUMAN	Transient receptor protein 5
# BioGrid	113075	18
# ChiTaRS	TRPC5	human
# ENZYME REGULATION	Calcium channel activity is enhanced by MYLK, that promotes its subcellular localization at the plasma membrane. {ECO:0000269|PubMed	16284075}. 
# Ensembl	ENST00000262839	ENSP00000262839; ENSG00000072315
# FUNCTION	TRPC5_HUMAN	Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. {ECO 0000250, ECO 0000269|PubMed 16284075}. 
# GO_component	GO:0005737	cytoplasm; IEA:Ensembl.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0030425	dendrite; IEA:Ensembl.
# GO_component	GO:0030426	growth cone; IEA:Ensembl.
# GO_component	GO:0034704	calcium channel complex; IDA:UniProtKB.
# GO_component	GO:0043025	neuronal cell body; IEA:Ensembl.
# GO_component	GO:0045121	membrane raft; IEA:Ensembl.
# GO_function	GO:0005262	calcium channel activity; IDA:UniProtKB.
# GO_function	GO:0015279	store-operated calcium channel activity; TAS:ProtInc.
# GO_function	GO:0070679	inositol 1,4,5 trisphosphate binding; IEA:Ensembl.
# GO_process	GO:0006816	calcium ion transport; TAS:ProtInc.
# GO_process	GO:0006828	manganese ion transport; IBA:GO_Central.
# GO_process	GO:0007204	positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
# GO_process	GO:0007399	nervous system development; TAS:ProtInc.
# GO_process	GO:0008284	positive regulation of cell proliferation; IEA:Ensembl.
# GO_process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation; IEA:Ensembl.
# GO_process	GO:0030182	neuron differentiation; IEA:Ensembl.
# GO_process	GO:0045773	positive regulation of axon extension; IEA:Ensembl.
# GO_process	GO:0050774	negative regulation of dendrite morphogenesis; IEA:Ensembl.
# GO_process	GO:0051480	regulation of cytosolic calcium ion concentration; IBA:GO_Central.
# GO_process	GO:0070588	calcium ion transmembrane transport; TAS:Reactome.
# GO_process	GO:1902630	regulation of membrane hyperpolarization; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005737	cytoplasm
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0030154	cell differentiation
# GOslim_process	GO:0042592	homeostatic process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	1.25.40.20	-; 1.
# Genevisible	Q9UL62	HS
# HGNC	HGNC:12337	TRPC5
# InterPro	IPR002110	Ankyrin_rpt
# InterPro	IPR002153	TRPC_channel
# InterPro	IPR004729	TRP_channel
# InterPro	IPR005461	TRPC5_channel
# InterPro	IPR005821	Ion_trans_dom
# InterPro	IPR013555	TRP_dom
# InterPro	IPR020683	Ankyrin_rpt-contain_dom
# KEGG_Brite	ko04040	Ion channels
# MIM	300334	gene
# Organism	TRPC5_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR10117	PTHR10117
# PANTHER	PTHR10117:SF24	PTHR10117:SF24
# PRINTS	PR01097	TRNSRECEPTRP
# PRINTS	PR01646	TRPCHANNEL5
# Pfam	PF00520	Ion_trans
# Pfam	PF08344	TRP_2
# Pfam	PF12796	Ank_2
# Proteomes	UP000005640	Chromosome X
# Reactome	R-HSA-3295583	TRP channels
# Reactome	R-HSA-418890	Role of second messengers in netrin-1 signaling
# RecName	TRPC5_HUMAN	Short transient receptor potential channel 5
# RefSeq	NP_036603	NM_012471.2
# RefSeq	XP_016885263	XM_017029774.1
# SIMILARITY	Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC5 sub-subfamily. {ECO	0000305}. 
# SIMILARITY	Contains 4 ANK repeats. {ECO	0000305}.
# SMART	SM00248	ANK; 2
# SUBCELLULAR LOCATION	TRPC5_HUMAN	Cell membrane {ECO 0000269|PubMed 16284075}; Multi-pass membrane protein {ECO 0000269|PubMed 16284075}. 
# SUBUNIT	TRPC5_HUMAN	Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC1 and/or TRPC4. Interacts with NHERF (By similarity). Interacts with MX1 and RNF24. Interacts (via C- terminus) with CABP1. Interacts with SESTD1 (via the spectrin 1 repeat). {ECO 0000250, ECO 0000269|PubMed 12032305, ECO 0000269|PubMed 15757897, ECO 0000269|PubMed 15895247, ECO 0000269|PubMed 17850865, ECO 0000269|PubMed 20164195}. 
# SUPFAM	SSF48403	SSF48403
# TCDB	1.A.4.1	the transient receptor potential ca(2+) channel (trp-cc) family
# TIGRFAMs	TIGR00870	trp
# TISSUE SPECIFICITY	Expressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole. {ECO:0000269|PubMed	9687496}. 
# UCSC	uc004epl	human
# eggNOG	ENOG410XQ0Y	LUCA
# eggNOG	KOG3609	Eukaryota
BLAST	swissprot:TRPC5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:TRPC5_HUMAN
BioCyc	ZFISH:ENSG00000072315-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000072315-MONOMER
COXPRESdb	7224	http://coxpresdb.jp/data/gene/7224.shtml
CleanEx	HS_TRPC5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_TRPC5
DOI	10.1006/geno.1999.5924	http://dx.doi.org/10.1006/geno.1999.5924
DOI	10.1007/s00424-005-1419-1	http://dx.doi.org/10.1007/s00424-005-1419-1
DOI	10.1016/j.ceca.2007.07.009	http://dx.doi.org/10.1016/j.ceca.2007.07.009
DOI	10.1038/nature03440	http://dx.doi.org/10.1038/nature03440
DOI	10.1056/NEJMoa1206524	http://dx.doi.org/10.1056/NEJMoa1206524
DOI	10.1073/pnas.102596199	http://dx.doi.org/10.1073/pnas.102596199
DOI	10.1074/jbc.M109.068304	http://dx.doi.org/10.1074/jbc.M109.068304
DOI	10.1074/jbc.M500391200	http://dx.doi.org/10.1074/jbc.M500391200
DOI	10.1093/emboj/17.15.4274	http://dx.doi.org/10.1093/emboj/17.15.4274
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1113/jphysiol.2005.097998	http://dx.doi.org/10.1113/jphysiol.2005.097998
EMBL	AC005191	http://www.ebi.ac.uk/ena/data/view/AC005191
EMBL	AC005191	http://www.ebi.ac.uk/ena/data/view/AC005191
EMBL	AF054568	http://www.ebi.ac.uk/ena/data/view/AF054568
EMBL	AL049563	http://www.ebi.ac.uk/ena/data/view/AL049563
EMBL	BC137271	http://www.ebi.ac.uk/ena/data/view/BC137271
EMBL	BC137274	http://www.ebi.ac.uk/ena/data/view/BC137274
EMBL	CH471120	http://www.ebi.ac.uk/ena/data/view/CH471120
Ensembl	ENST00000262839	http://www.ensembl.org/id/ENST00000262839
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0030426	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030426
GO_component	GO:0034704	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034704
GO_component	GO:0043025	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043025
GO_component	GO:0045121	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045121
GO_function	GO:0005262	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262
GO_function	GO:0015279	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015279
GO_function	GO:0070679	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070679
GO_process	GO:0006816	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006816
GO_process	GO:0006828	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006828
GO_process	GO:0007204	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007204
GO_process	GO:0007399	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007399
GO_process	GO:0008284	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008284
GO_process	GO:0010800	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010800
GO_process	GO:0030182	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030182
GO_process	GO:0045773	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045773
GO_process	GO:0050774	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050774
GO_process	GO:0051480	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051480
GO_process	GO:0070588	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588
GO_process	GO:1902630	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902630
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005737	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0030154	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154
GOslim_process	GO:0042592	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	1.25.40.20	http://www.cathdb.info/version/latest/superfamily/1.25.40.20
GeneCards	TRPC5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TRPC5
GeneID	7224	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7224
GeneTree	ENSGT00760000119180	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119180
HGNC	HGNC:12337	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:12337
HOGENOM	HOG000020589	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000020589&db=HOGENOM6
HOVERGEN	HBG068337	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG068337&db=HOVERGEN
InParanoid	Q9UL62	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UL62
IntAct	Q9UL62	http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9UL62*
InterPro	IPR002110	http://www.ebi.ac.uk/interpro/entry/IPR002110
InterPro	IPR002153	http://www.ebi.ac.uk/interpro/entry/IPR002153
InterPro	IPR004729	http://www.ebi.ac.uk/interpro/entry/IPR004729
InterPro	IPR005461	http://www.ebi.ac.uk/interpro/entry/IPR005461
InterPro	IPR005821	http://www.ebi.ac.uk/interpro/entry/IPR005821
InterPro	IPR013555	http://www.ebi.ac.uk/interpro/entry/IPR013555
InterPro	IPR020683	http://www.ebi.ac.uk/interpro/entry/IPR020683
Jabion	7224	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=7224
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:7224	http://www.genome.jp/dbget-bin/www_bget?hsa:7224
KEGG_Orthology	KO:K04968	http://www.genome.jp/dbget-bin/www_bget?KO:K04968
MIM	300334	http://www.ncbi.nlm.nih.gov/omim/300334
OMA	NCSKSEI	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NCSKSEI
OrthoDB	EOG091G029I	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G029I
PANTHER	PTHR10117	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10117
PANTHER	PTHR10117:SF24	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10117:SF24
PRINTS	PR01097	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01097
PRINTS	PR01646	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01646
PSORT	swissprot:TRPC5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:TRPC5_HUMAN
PSORT-B	swissprot:TRPC5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:TRPC5_HUMAN
PSORT2	swissprot:TRPC5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:TRPC5_HUMAN
Pfam	PF00520	http://pfam.xfam.org/family/PF00520
Pfam	PF08344	http://pfam.xfam.org/family/PF08344
Pfam	PF12796	http://pfam.xfam.org/family/PF12796
PharmGKB	PA37010	http://www.pharmgkb.org/do/serve?objId=PA37010&objCls=Gene
Phobius	swissprot:TRPC5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:TRPC5_HUMAN
PhylomeDB	Q9UL62	http://phylomedb.org/?seqid=Q9UL62
ProteinModelPortal	Q9UL62	http://www.proteinmodelportal.org/query/uniprot/Q9UL62
PubMed	10493832	http://www.ncbi.nlm.nih.gov/pubmed/10493832
PubMed	12032305	http://www.ncbi.nlm.nih.gov/pubmed/12032305
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	15757897	http://www.ncbi.nlm.nih.gov/pubmed/15757897
PubMed	15772651	http://www.ncbi.nlm.nih.gov/pubmed/15772651
PubMed	15895247	http://www.ncbi.nlm.nih.gov/pubmed/15895247
PubMed	16284075	http://www.ncbi.nlm.nih.gov/pubmed/16284075
PubMed	17850865	http://www.ncbi.nlm.nih.gov/pubmed/17850865
PubMed	20164195	http://www.ncbi.nlm.nih.gov/pubmed/20164195
PubMed	23033978	http://www.ncbi.nlm.nih.gov/pubmed/23033978
PubMed	9687496	http://www.ncbi.nlm.nih.gov/pubmed/9687496
Reactome	R-HSA-3295583	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3295583
Reactome	R-HSA-418890	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-418890
RefSeq	NP_036603	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_036603
RefSeq	XP_016885263	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_016885263
SMART	SM00248	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00248
STRING	9606.ENSP00000262839	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000262839&targetmode=cogs
SUPFAM	SSF48403	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48403
TCDB	1.A.4.1	http://www.tcdb.org/search/result.php?tc=1.A.4.1
TIGRFAMs	TIGR00870	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00870
UCSC	uc004epl	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc004epl&org=rat
UniGene	Hs.657709	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.657709
UniProtKB	TRPC5_HUMAN	http://www.uniprot.org/uniprot/TRPC5_HUMAN
UniProtKB-AC	Q9UL62	http://www.uniprot.org/uniprot/Q9UL62
charge	swissprot:TRPC5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:TRPC5_HUMAN
eggNOG	ENOG410XQ0Y	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ0Y
eggNOG	KOG3609	http://eggnogapi.embl.de/nog_data/html/tree/KOG3609
epestfind	swissprot:TRPC5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:TRPC5_HUMAN
garnier	swissprot:TRPC5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:TRPC5_HUMAN
helixturnhelix	swissprot:TRPC5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRPC5_HUMAN
hmoment	swissprot:TRPC5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:TRPC5_HUMAN
iep	swissprot:TRPC5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:TRPC5_HUMAN
inforesidue	swissprot:TRPC5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:TRPC5_HUMAN
neXtProt	NX_Q9UL62	http://www.nextprot.org/db/entry/NX_Q9UL62
octanol	swissprot:TRPC5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:TRPC5_HUMAN
pepcoil	swissprot:TRPC5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:TRPC5_HUMAN
pepdigest	swissprot:TRPC5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:TRPC5_HUMAN
pepinfo	swissprot:TRPC5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:TRPC5_HUMAN
pepnet	swissprot:TRPC5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:TRPC5_HUMAN
pepstats	swissprot:TRPC5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:TRPC5_HUMAN
pepwheel	swissprot:TRPC5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:TRPC5_HUMAN
pepwindow	swissprot:TRPC5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:TRPC5_HUMAN
sigcleave	swissprot:TRPC5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:TRPC5_HUMAN
## Database	ID	URL or Descriptions
# AltName	GBRA5_HUMAN	GABA(A) receptor subunit alpha-5
# DrugBank	DB00186	Lorazepam
# DrugBank	DB00189	Ethchlorvynol
# DrugBank	DB00228	Enflurane
# DrugBank	DB00231	Temazepam
# DrugBank	DB00237	Butabarbital
# DrugBank	DB00241	Butalbital
# DrugBank	DB00273	Topiramate
# DrugBank	DB00292	Etomidate
# DrugBank	DB00306	Talbutal
# DrugBank	DB00312	Pentobarbital
# DrugBank	DB00334	Olanzapine
# DrugBank	DB00349	Clobazam
# DrugBank	DB00371	Meprobamate
# DrugBank	DB00402	Eszopiclone
# DrugBank	DB00404	Alprazolam
# DrugBank	DB00418	Secobarbital
# DrugBank	DB00475	Chlordiazepoxide
# DrugBank	DB00543	Amoxapine
# DrugBank	DB00546	Adinazolam
# DrugBank	DB00599	Thiopental
# DrugBank	DB00628	Clorazepate
# DrugBank	DB00659	Acamprosate
# DrugBank	DB00683	Midazolam
# DrugBank	DB00690	Flurazepam
# DrugBank	DB00753	Isoflurane
# DrugBank	DB00794	Primidone
# DrugBank	DB00801	Halazepam
# DrugBank	DB00818	Propofol
# DrugBank	DB00829	Diazepam
# DrugBank	DB00842	Oxazepam
# DrugBank	DB00849	Methylphenobarbital
# DrugBank	DB00897	Triazolam
# DrugBank	DB00898	Ethanol
# DrugBank	DB01028	Methoxyflurane
# DrugBank	DB01049	Ergoloid mesylate
# DrugBank	DB01068	Clonazepam
# DrugBank	DB01107	Methyprylon
# DrugBank	DB01159	Halothane
# DrugBank	DB01189	Desflurane
# DrugBank	DB01198	Zopiclone
# DrugBank	DB01205	Flumazenil
# DrugBank	DB01215	Estazolam
# DrugBank	DB01236	Sevoflurane
# DrugBank	DB01351	Amobarbital
# DrugBank	DB01352	Aprobarbital
# DrugBank	DB01353	Butethal
# DrugBank	DB01354	Heptabarbital
# DrugBank	DB01355	Hexobarbital
# DrugBank	DB01437	Glutethimide
# DrugBank	DB01544	Flunitrazepam
# DrugBank	DB01558	Bromazepam
# DrugBank	DB01559	Clotiazepam
# DrugBank	DB01567	Fludiazepam
# DrugBank	DB01588	Prazepam
# DrugBank	DB01589	Quazepam
# DrugBank	DB01594	Cinolazepam
# DrugBank	DB01595	Nitrazepam
# Ensembl	ENST00000335625	ENSP00000335592; ENSG00000186297
# Ensembl	ENST00000355395	ENSP00000347557; ENSG00000186297
# Ensembl	ENST00000400081	ENSP00000382953; ENSG00000186297
# ExpressionAtlas	P31644	baseline and differential
# FUNCTION	GBRA5_HUMAN	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0005887	integral component of plasma membrane; TAS:ProtInc.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0030425	dendrite; IEA:Ensembl.
# GO_component	GO:0032809	neuronal cell body membrane; IEA:Ensembl.
# GO_component	GO:0034707	chloride channel complex; IEA:UniProtKB-KW.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-SubCell.
# GO_component	GO:1902711	GABA-A receptor complex; IBA:GO_Central.
# GO_function	GO:0004872	receptor activity; TAS:ProtInc.
# GO_function	GO:0004890	GABA-A receptor activity; IEA:Ensembl.
# GO_function	GO:0005215	transporter activity; TAS:ProtInc.
# GO_function	GO:0005230	extracellular ligand-gated ion channel activity; IEA:InterPro.
# GO_function	GO:0005254	chloride channel activity; IEA:UniProtKB-KW.
# GO_process	GO:0001662	behavioral fear response; IEA:Ensembl.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0007165	signal transduction; TAS:ProtInc.
# GO_process	GO:0007214	gamma-aminobutyric acid signaling pathway; IEA:InterPro.
# GO_process	GO:0007268	chemical synaptic transmission; IEA:Ensembl.
# GO_process	GO:0007420	brain development; IEA:Ensembl.
# GO_process	GO:0007605	sensory perception of sound; IEA:Ensembl.
# GO_process	GO:0008306	associative learning; IEA:Ensembl.
# GO_process	GO:0034220	ion transmembrane transport; TAS:Reactome.
# GO_process	GO:0043524	negative regulation of neuron apoptotic process; IEA:Ensembl.
# GO_process	GO:0060119	inner ear receptor cell development; IEA:Ensembl.
# GO_process	GO:0060384	innervation; IEA:Ensembl.
# GO_process	GO:0090102	cochlea development; IEA:Ensembl.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0004871	signal transducer activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0006950	response to stress
# GOslim_process	GO:0007165	signal transduction
# GOslim_process	GO:0007267	cell-cell signaling
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0048856	anatomical structure development
# GOslim_process	GO:0050877	neurological system process
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	2.70.170.10	-; 1.
# Genevisible	P31644	HS
# HGNC	HGNC:4079	GABRA5
# InterPro	IPR001390	GABAAa_rcpt
# InterPro	IPR005435	GABBAa5_rcpt
# InterPro	IPR006028	GABAA/Glycine_rcpt
# InterPro	IPR006029	Neurotrans-gated_channel_TM
# InterPro	IPR006201	Neur_channel
# InterPro	IPR006202	Neur_chan_lig-bd
# InterPro	IPR018000	Neurotransmitter_ion_chnl_CS
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04080	Neuroactive ligand-receptor interaction
# KEGG_Pathway	ko04723	Retrograde endocannabinoid signaling
# KEGG_Pathway	ko04727	GABAergic synapse
# KEGG_Pathway	ko05032	Morphine addiction
# KEGG_Pathway	ko05033	Nicotine addiction
# MIM	137142	gene
# Organism	GBRA5_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR18945	PTHR18945
# PIR	A48933	A48933
# PRINTS	PR00252	NRIONCHANNEL
# PRINTS	PR00253	GABAARECEPTR
# PRINTS	PR01079	GABAARALPHA
# PRINTS	PR01618	GABAARALPHA5
# PROSITE	PS00236	NEUROTR_ION_CHANNEL
# Pfam	PF02931	Neur_chan_LBD
# Pfam	PF02932	Neur_chan_memb
# Proteomes	UP000005640	Chromosome 15
# Reactome	R-HSA-112314	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
# Reactome	R-HSA-975298	Ligand-gated ion channel transport
# Reactome	R-HSA-977441	GABA A receptor activation
# RecName	GBRA5_HUMAN	Gamma-aminobutyric acid receptor subunit alpha-5
# RefSeq	NP_000801	NM_000810.3
# RefSeq	NP_001158509	NM_001165037.1
# RefSeq	XP_005268315	XM_005268258.2
# RefSeq	XP_006720522	XM_006720459.2
# SIMILARITY	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA5 sub-subfamily. {ECO	0000305}. 
# SUBCELLULAR LOCATION	GBRA5_HUMAN	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. 
# SUBUNIT	Generally pentameric. There are five types of GABA(A) receptor chains	 alpha, beta, gamma, delta, and rho. 
# SUPFAM	SSF63712	SSF63712
# SUPFAM	SSF90112	SSF90112
# TIGRFAMs	TIGR00860	LIC
# UCSC	uc001zbd	human
# WEB RESOURCE	GBRA5_HUMAN	Name=Protein Spotlight; Note=Forbidden fruit - Issue 56 of March 2005; URL="http //web.expasy.org/spotlight/back_issues/056";
# eggNOG	ENOG410XNQG	LUCA
# eggNOG	KOG3642	Eukaryota
BLAST	swissprot:GBRA5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:GBRA5_HUMAN
BioCyc	ZFISH:G66-33773-MONOMER	http://biocyc.org/getid?id=ZFISH:G66-33773-MONOMER
COXPRESdb	2558	http://coxpresdb.jp/data/gene/2558.shtml
CleanEx	HS_GABRA5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_GABRA5
DOI	10.1002/pmic.200600410	http://dx.doi.org/10.1002/pmic.200600410
DOI	10.1006/geno.1997.4770	http://dx.doi.org/10.1006/geno.1997.4770
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1042/bst020018s	http://dx.doi.org/10.1042/bst020018s
DOI	10.1093/hmg/2.2.183	http://dx.doi.org/10.1093/hmg/2.2.183
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DrugBank	DB00186	http://www.drugbank.ca/drugs/DB00186
DrugBank	DB00189	http://www.drugbank.ca/drugs/DB00189
DrugBank	DB00228	http://www.drugbank.ca/drugs/DB00228
DrugBank	DB00231	http://www.drugbank.ca/drugs/DB00231
DrugBank	DB00237	http://www.drugbank.ca/drugs/DB00237
DrugBank	DB00241	http://www.drugbank.ca/drugs/DB00241
DrugBank	DB00273	http://www.drugbank.ca/drugs/DB00273
DrugBank	DB00292	http://www.drugbank.ca/drugs/DB00292
DrugBank	DB00306	http://www.drugbank.ca/drugs/DB00306
DrugBank	DB00312	http://www.drugbank.ca/drugs/DB00312
DrugBank	DB00334	http://www.drugbank.ca/drugs/DB00334
DrugBank	DB00349	http://www.drugbank.ca/drugs/DB00349
DrugBank	DB00371	http://www.drugbank.ca/drugs/DB00371
DrugBank	DB00402	http://www.drugbank.ca/drugs/DB00402
DrugBank	DB00404	http://www.drugbank.ca/drugs/DB00404
DrugBank	DB00418	http://www.drugbank.ca/drugs/DB00418
DrugBank	DB00475	http://www.drugbank.ca/drugs/DB00475
DrugBank	DB00543	http://www.drugbank.ca/drugs/DB00543
DrugBank	DB00546	http://www.drugbank.ca/drugs/DB00546
DrugBank	DB00599	http://www.drugbank.ca/drugs/DB00599
DrugBank	DB00628	http://www.drugbank.ca/drugs/DB00628
DrugBank	DB00659	http://www.drugbank.ca/drugs/DB00659
DrugBank	DB00683	http://www.drugbank.ca/drugs/DB00683
DrugBank	DB00690	http://www.drugbank.ca/drugs/DB00690
DrugBank	DB00753	http://www.drugbank.ca/drugs/DB00753
DrugBank	DB00794	http://www.drugbank.ca/drugs/DB00794
DrugBank	DB00801	http://www.drugbank.ca/drugs/DB00801
DrugBank	DB00818	http://www.drugbank.ca/drugs/DB00818
DrugBank	DB00829	http://www.drugbank.ca/drugs/DB00829
DrugBank	DB00842	http://www.drugbank.ca/drugs/DB00842
DrugBank	DB00849	http://www.drugbank.ca/drugs/DB00849
DrugBank	DB00897	http://www.drugbank.ca/drugs/DB00897
DrugBank	DB00898	http://www.drugbank.ca/drugs/DB00898
DrugBank	DB01028	http://www.drugbank.ca/drugs/DB01028
DrugBank	DB01049	http://www.drugbank.ca/drugs/DB01049
DrugBank	DB01068	http://www.drugbank.ca/drugs/DB01068
DrugBank	DB01107	http://www.drugbank.ca/drugs/DB01107
DrugBank	DB01159	http://www.drugbank.ca/drugs/DB01159
DrugBank	DB01189	http://www.drugbank.ca/drugs/DB01189
DrugBank	DB01198	http://www.drugbank.ca/drugs/DB01198
DrugBank	DB01205	http://www.drugbank.ca/drugs/DB01205
DrugBank	DB01215	http://www.drugbank.ca/drugs/DB01215
DrugBank	DB01236	http://www.drugbank.ca/drugs/DB01236
DrugBank	DB01351	http://www.drugbank.ca/drugs/DB01351
DrugBank	DB01352	http://www.drugbank.ca/drugs/DB01352
DrugBank	DB01353	http://www.drugbank.ca/drugs/DB01353
DrugBank	DB01354	http://www.drugbank.ca/drugs/DB01354
DrugBank	DB01355	http://www.drugbank.ca/drugs/DB01355
DrugBank	DB01437	http://www.drugbank.ca/drugs/DB01437
DrugBank	DB01544	http://www.drugbank.ca/drugs/DB01544
DrugBank	DB01558	http://www.drugbank.ca/drugs/DB01558
DrugBank	DB01559	http://www.drugbank.ca/drugs/DB01559
DrugBank	DB01567	http://www.drugbank.ca/drugs/DB01567
DrugBank	DB01588	http://www.drugbank.ca/drugs/DB01588
DrugBank	DB01589	http://www.drugbank.ca/drugs/DB01589
DrugBank	DB01594	http://www.drugbank.ca/drugs/DB01594
DrugBank	DB01595	http://www.drugbank.ca/drugs/DB01595
EMBL	AF061785	http://www.ebi.ac.uk/ena/data/view/AF061785
EMBL	AF228447	http://www.ebi.ac.uk/ena/data/view/AF228447
EMBL	AF228448	http://www.ebi.ac.uk/ena/data/view/AF228448
EMBL	AF228449	http://www.ebi.ac.uk/ena/data/view/AF228449
EMBL	AK290453	http://www.ebi.ac.uk/ena/data/view/AK290453
EMBL	BC111979	http://www.ebi.ac.uk/ena/data/view/BC111979
EMBL	BC113422	http://www.ebi.ac.uk/ena/data/view/BC113422
EMBL	BT009830	http://www.ebi.ac.uk/ena/data/view/BT009830
EMBL	L08485	http://www.ebi.ac.uk/ena/data/view/L08485
Ensembl	ENST00000335625	http://www.ensembl.org/id/ENST00000335625
Ensembl	ENST00000355395	http://www.ensembl.org/id/ENST00000355395
Ensembl	ENST00000400081	http://www.ensembl.org/id/ENST00000400081
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0005887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0030425	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030425
GO_component	GO:0032809	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032809
GO_component	GO:0034707	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_component	GO:1902711	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902711
GO_function	GO:0004872	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004872
GO_function	GO:0004890	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004890
GO_function	GO:0005215	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215
GO_function	GO:0005230	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005230
GO_function	GO:0005254	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005254
GO_process	GO:0001662	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001662
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GO_process	GO:0007214	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007214
GO_process	GO:0007268	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007268
GO_process	GO:0007420	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007420
GO_process	GO:0007605	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007605
GO_process	GO:0008306	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008306
GO_process	GO:0034220	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220
GO_process	GO:0043524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043524
GO_process	GO:0060119	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060119
GO_process	GO:0060384	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060384
GO_process	GO:0090102	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090102
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0004871	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0006950	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_process	GO:0007165	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_process	GO:0007267	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0048856	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	2.70.170.10	http://www.cathdb.info/version/latest/superfamily/2.70.170.10
GeneCards	GABRA5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GABRA5
GeneID	2558	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2558
GeneTree	ENSGT00760000119010	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000119010
HGNC	HGNC:4079	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:4079
HOGENOM	HOG000231337	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231337&db=HOGENOM6
HOVERGEN	HBG051707	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051707&db=HOVERGEN
InParanoid	P31644	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31644
InterPro	IPR001390	http://www.ebi.ac.uk/interpro/entry/IPR001390
InterPro	IPR005435	http://www.ebi.ac.uk/interpro/entry/IPR005435
InterPro	IPR006028	http://www.ebi.ac.uk/interpro/entry/IPR006028
InterPro	IPR006029	http://www.ebi.ac.uk/interpro/entry/IPR006029
InterPro	IPR006201	http://www.ebi.ac.uk/interpro/entry/IPR006201
InterPro	IPR006202	http://www.ebi.ac.uk/interpro/entry/IPR006202
InterPro	IPR018000	http://www.ebi.ac.uk/interpro/entry/IPR018000
Jabion	2558	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=2558
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:2558	http://www.genome.jp/dbget-bin/www_bget?hsa:2558
KEGG_Orthology	KO:K05175	http://www.genome.jp/dbget-bin/www_bget?KO:K05175
KEGG_Pathway	ko04080	http://www.genome.jp/kegg-bin/show_pathway?ko04080
KEGG_Pathway	ko04723	http://www.genome.jp/kegg-bin/show_pathway?ko04723
KEGG_Pathway	ko04727	http://www.genome.jp/kegg-bin/show_pathway?ko04727
KEGG_Pathway	ko05032	http://www.genome.jp/kegg-bin/show_pathway?ko05032
KEGG_Pathway	ko05033	http://www.genome.jp/kegg-bin/show_pathway?ko05033
MIM	137142	http://www.ncbi.nlm.nih.gov/omim/137142
OMA	WDGKKAS	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WDGKKAS
OrthoDB	EOG091G0805	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0805
PANTHER	PTHR18945	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945
PRINTS	PR00252	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00252
PRINTS	PR00253	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00253
PRINTS	PR01079	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01079
PRINTS	PR01618	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01618
PROSITE	PS00236	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00236
PSORT	swissprot:GBRA5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:GBRA5_HUMAN
PSORT-B	swissprot:GBRA5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:GBRA5_HUMAN
PSORT2	swissprot:GBRA5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:GBRA5_HUMAN
Pfam	PF02931	http://pfam.xfam.org/family/PF02931
Pfam	PF02932	http://pfam.xfam.org/family/PF02932
PharmGKB	PA28493	http://www.pharmgkb.org/do/serve?objId=PA28493&objCls=Gene
Phobius	swissprot:GBRA5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:GBRA5_HUMAN
PhylomeDB	P31644	http://phylomedb.org/?seqid=P31644
ProteinModelPortal	P31644	http://www.proteinmodelportal.org/query/uniprot/P31644
PubMed	1321750	http://www.ncbi.nlm.nih.gov/pubmed/1321750
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	17370265	http://www.ncbi.nlm.nih.gov/pubmed/17370265
PubMed	8388764	http://www.ncbi.nlm.nih.gov/pubmed/8388764
PubMed	9205108	http://www.ncbi.nlm.nih.gov/pubmed/9205108
Reactome	R-HSA-112314	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-112314
Reactome	R-HSA-975298	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-975298
Reactome	R-HSA-977441	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-977441
RefSeq	NP_000801	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_000801
RefSeq	NP_001158509	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001158509
RefSeq	XP_005268315	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005268315
RefSeq	XP_006720522	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_006720522
STRING	9606.ENSP00000335592	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000335592&targetmode=cogs
SUPFAM	SSF63712	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63712
SUPFAM	SSF90112	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90112
TIGRFAMs	TIGR00860	http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00860
UCSC	uc001zbd	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001zbd&org=rat
UniGene	Hs.24969	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.24969
UniProtKB	GBRA5_HUMAN	http://www.uniprot.org/uniprot/GBRA5_HUMAN
UniProtKB-AC	P31644	http://www.uniprot.org/uniprot/P31644
charge	swissprot:GBRA5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:GBRA5_HUMAN
eggNOG	ENOG410XNQG	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNQG
eggNOG	KOG3642	http://eggnogapi.embl.de/nog_data/html/tree/KOG3642
epestfind	swissprot:GBRA5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:GBRA5_HUMAN
garnier	swissprot:GBRA5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:GBRA5_HUMAN
helixturnhelix	swissprot:GBRA5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:GBRA5_HUMAN
hmoment	swissprot:GBRA5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:GBRA5_HUMAN
iep	swissprot:GBRA5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:GBRA5_HUMAN
inforesidue	swissprot:GBRA5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:GBRA5_HUMAN
neXtProt	NX_P31644	http://www.nextprot.org/db/entry/NX_P31644
octanol	swissprot:GBRA5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:GBRA5_HUMAN
pepcoil	swissprot:GBRA5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:GBRA5_HUMAN
pepdigest	swissprot:GBRA5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:GBRA5_HUMAN
pepinfo	swissprot:GBRA5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:GBRA5_HUMAN
pepnet	swissprot:GBRA5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:GBRA5_HUMAN
pepstats	swissprot:GBRA5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:GBRA5_HUMAN
pepwheel	swissprot:GBRA5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:GBRA5_HUMAN
pepwindow	swissprot:GBRA5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:GBRA5_HUMAN
sigcleave	swissprot:GBRA5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:GBRA5_HUMAN
## Database	ID	URL or Descriptions
# AltName	CCG5_HUMAN	Neuronal voltage-gated calcium channel gamma-5 subunit
# AltName	CCG5_HUMAN	Transmembrane AMPAR regulatory protein gamma-5
# BioGrid	117993	39
# Ensembl	ENST00000307139	ENSP00000303092; ENSG00000075429
# Ensembl	ENST00000533854	ENSP00000436836; ENSG00000075429
# FUNCTION	CCG5_HUMAN	Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity). {ECO 0000250}. 
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0014069	postsynaptic density; ISS:UniProtKB.
# GO_component	GO:0030054	cell junction; IEA:UniProtKB-KW.
# GO_component	GO:0032281	AMPA glutamate receptor complex; ISS:UniProtKB.
# GO_component	GO:0045211	postsynaptic membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005245	voltage-gated calcium channel activity; TAS:ProtInc.
# GO_function	GO:0015075	ion transmembrane transporter activity; TAS:ProtInc.
# GO_function	GO:0016247	channel regulator activity; IBA:GO_Central.
# GO_process	GO:0006810	transport; TAS:ProtInc.
# GO_process	GO:0019226	transmission of nerve impulse; IBA:GO_Central.
# GO_process	GO:0061337	cardiac conduction; TAS:Reactome.
# GO_process	GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; ISS:UniProtKB.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_component	GO:0043226	organelle
# GOslim_function	GO:0003674	molecular_function
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0008150	biological_process
# GOslim_process	GO:0050877	neurological system process
# Genevisible	Q9UF02	HS
# HGNC	HGNC:1409	CACNG5
# InterPro	IPR004031	PMP22/EMP/MP20/Claudin
# InterPro	IPR008368	VDCC_gsu
# InterPro	IPR008369	VDCC_g5su
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko04040	 Ion channels
# KEGG_Pathway	ko04010	MAPK signaling pathway
# KEGG_Pathway	ko04260	Cardiac muscle contraction
# KEGG_Pathway	ko05410	Hypertrophic cardiomyopathy (HCM)
# KEGG_Pathway	ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
# KEGG_Pathway	ko05414	Dilated cardiomyopathy
# MIM	606405	gene
# Organism	CCG5_HUMAN	Homo sapiens (Human)
# PRINTS	PR01792	VDCCGAMMA
# PRINTS	PR01793	VDCCGAMMA5
# Pfam	PF00822	PMP22_Claudin
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
# Reactome	R-HSA-5576893	Phase 2 - plateau phase
# Reactome	R-HSA-5576894	Phase 1 - inactivation of fast Na+ channels
# RecName	CCG5_HUMAN	Voltage-dependent calcium channel gamma-5 subunit
# RefSeq	NP_665810	NM_145811.2
# SIMILARITY	Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. {ECO	0000305}.
# SUBCELLULAR LOCATION	CCG5_HUMAN	Membrane {ECO 0000250}; Multi-pass membrane protein {ECO 0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO 0000250}. 
# SUBUNIT	The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG7 and CACNG8. Interacts with GRIA1, GRIA2, GRIA3 and GRIA4 (By similarity). {ECO	0000250}. 
# UCSC	uc010wqi	human
# eggNOG	ENOG410IXFC	Eukaryota
# eggNOG	ENOG410XUAQ	LUCA
BLAST	swissprot:CCG5_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:CCG5_HUMAN
BioCyc	ZFISH:ENSG00000075429-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000075429-MONOMER
COXPRESdb	27091	http://coxpresdb.jp/data/gene/27091.shtml
CleanEx	HS_CACNG5	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_CACNG5
DOI	10.1016/S0378-1119(01)00738-7	http://dx.doi.org/10.1016/S0378-1119(01)00738-7
DOI	10.1038/ng1285	http://dx.doi.org/10.1038/ng1285
DOI	10.1093/emboj/21.7.1514	http://dx.doi.org/10.1093/emboj/21.7.1514
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
DOI	10.1101/gr.9.12.1204	http://dx.doi.org/10.1101/gr.9.12.1204
EMBL	AF142618	http://www.ebi.ac.uk/ena/data/view/AF142618
EMBL	AF142619	http://www.ebi.ac.uk/ena/data/view/AF142619
EMBL	AF142620	http://www.ebi.ac.uk/ena/data/view/AF142620
EMBL	AF142621	http://www.ebi.ac.uk/ena/data/view/AF142621
EMBL	AF148220	http://www.ebi.ac.uk/ena/data/view/AF148220
EMBL	AF361351	http://www.ebi.ac.uk/ena/data/view/AF361351
EMBL	AF458898	http://www.ebi.ac.uk/ena/data/view/AF458898
EMBL	AK290171	http://www.ebi.ac.uk/ena/data/view/AK290171
EMBL	BC101607	http://www.ebi.ac.uk/ena/data/view/BC101607
EMBL	BC101633	http://www.ebi.ac.uk/ena/data/view/BC101633
Ensembl	ENST00000307139	http://www.ensembl.org/id/ENST00000307139
Ensembl	ENST00000533854	http://www.ensembl.org/id/ENST00000533854
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0014069	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014069
GO_component	GO:0030054	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030054
GO_component	GO:0032281	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032281
GO_component	GO:0045211	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045211
GO_function	GO:0005245	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005245
GO_function	GO:0015075	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015075
GO_function	GO:0016247	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016247
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0019226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019226
GO_process	GO:0061337	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061337
GO_process	GO:2000311	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000311
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_component	GO:0043226	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226
GOslim_function	GO:0003674	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0008150	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_process	GO:0050877	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
GeneCards	CACNG5	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CACNG5
GeneID	27091	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27091
GeneTree	ENSGT00550000074547	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00550000074547
HGNC	HGNC:1409	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1409
HOGENOM	HOG000233439	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233439&db=HOGENOM6
HOVERGEN	HBG025923	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG025923&db=HOVERGEN
HPA	HPA050115	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA050115
InParanoid	Q9UF02	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q9UF02
InterPro	IPR004031	http://www.ebi.ac.uk/interpro/entry/IPR004031
InterPro	IPR008368	http://www.ebi.ac.uk/interpro/entry/IPR008368
InterPro	IPR008369	http://www.ebi.ac.uk/interpro/entry/IPR008369
Jabion	27091	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=27091
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko04040	http://www.genome.jp/dbget-bin/www_bget?ko04040
KEGG_Gene	hsa:27091	http://www.genome.jp/dbget-bin/www_bget?hsa:27091
KEGG_Orthology	KO:K04870	http://www.genome.jp/dbget-bin/www_bget?KO:K04870
KEGG_Pathway	ko04010	http://www.genome.jp/kegg-bin/show_pathway?ko04010
KEGG_Pathway	ko04260	http://www.genome.jp/kegg-bin/show_pathway?ko04260
KEGG_Pathway	ko05410	http://www.genome.jp/kegg-bin/show_pathway?ko05410
KEGG_Pathway	ko05412	http://www.genome.jp/kegg-bin/show_pathway?ko05412
KEGG_Pathway	ko05414	http://www.genome.jp/kegg-bin/show_pathway?ko05414
MIM	606405	http://www.ncbi.nlm.nih.gov/omim/606405
OMA	LKCPEYE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LKCPEYE
OrthoDB	EOG091G0F73	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0F73
PRINTS	PR01792	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01792
PRINTS	PR01793	http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01793
PSORT	swissprot:CCG5_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:CCG5_HUMAN
PSORT-B	swissprot:CCG5_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:CCG5_HUMAN
PSORT2	swissprot:CCG5_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:CCG5_HUMAN
Pfam	PF00822	http://pfam.xfam.org/family/PF00822
PharmGKB	PA26019	http://www.pharmgkb.org/do/serve?objId=PA26019&objCls=Gene
Phobius	swissprot:CCG5_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:CCG5_HUMAN
PhylomeDB	Q9UF02	http://phylomedb.org/?seqid=Q9UF02
ProteinModelPortal	Q9UF02	http://www.proteinmodelportal.org/query/uniprot/Q9UF02
PubMed	10613843	http://www.ncbi.nlm.nih.gov/pubmed/10613843
PubMed	11738816	http://www.ncbi.nlm.nih.gov/pubmed/11738816
PubMed	11927536	http://www.ncbi.nlm.nih.gov/pubmed/11927536
PubMed	14702039	http://www.ncbi.nlm.nih.gov/pubmed/14702039
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
Reactome	R-HSA-5576892	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576892
Reactome	R-HSA-5576893	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576893
Reactome	R-HSA-5576894	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5576894
RefSeq	NP_665810	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_665810
STRING	9606.ENSP00000303092	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000303092&targetmode=cogs
UCSC	uc010wqi	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010wqi&org=rat
UniGene	Hs.278907	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.278907
UniProtKB	CCG5_HUMAN	http://www.uniprot.org/uniprot/CCG5_HUMAN
UniProtKB-AC	Q9UF02	http://www.uniprot.org/uniprot/Q9UF02
charge	swissprot:CCG5_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:CCG5_HUMAN
eggNOG	ENOG410IXFC	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410IXFC
eggNOG	ENOG410XUAQ	http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XUAQ
epestfind	swissprot:CCG5_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:CCG5_HUMAN
garnier	swissprot:CCG5_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:CCG5_HUMAN
helixturnhelix	swissprot:CCG5_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:CCG5_HUMAN
hmoment	swissprot:CCG5_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:CCG5_HUMAN
iep	swissprot:CCG5_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:CCG5_HUMAN
inforesidue	swissprot:CCG5_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:CCG5_HUMAN
neXtProt	NX_Q9UF02	http://www.nextprot.org/db/entry/NX_Q9UF02
octanol	swissprot:CCG5_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:CCG5_HUMAN
pepcoil	swissprot:CCG5_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:CCG5_HUMAN
pepdigest	swissprot:CCG5_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:CCG5_HUMAN
pepinfo	swissprot:CCG5_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:CCG5_HUMAN
pepnet	swissprot:CCG5_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:CCG5_HUMAN
pepstats	swissprot:CCG5_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:CCG5_HUMAN
pepwheel	swissprot:CCG5_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:CCG5_HUMAN
pepwindow	swissprot:CCG5_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:CCG5_HUMAN
sigcleave	swissprot:CCG5_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:CCG5_HUMAN
## Database	ID	URL or Descriptions
# ALTERNATIVE PRODUCTS	ABCA8_HUMAN	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O94911-1; Sequence=Displayed; Name=2; IsoId=O94911-2; Sequence=VSP_020703; Note=No experimental confirmation available.; Name=3; IsoId=O94911-3; Sequence=VSP_053440; Note=No experimental confirmation available.; 
# BIOPHYSICOCHEMICAL PROPERTIES	ABCA8_HUMAN	Kinetic parameters  KM=30.4 uM for estradiol-beta-glucuronide {ECO 0000269|PubMed 12379217}; KM=0.1 uM for LTC4 {ECO 0000269|PubMed 12379217}; KM=10.3 uM for taurochlorate {ECO 0000269|PubMed 12379217}; KM=5.0 uM for PAH {ECO 0000269|PubMed 12379217}; KM=0.5 uM for estrone sulfate {ECO 0000269|PubMed 12379217}; KM=0.4 uM for ochratoxin A {ECO 0000269|PubMed 12379217}; 
# CCDS	CCDS11680	-. [O94911-1]
# CCDS	CCDS74139	-. [O94911-3]
# ChiTaRS	ABCA8	human
# Ensembl	ENST00000269080	ENSP00000269080; ENSG00000141338. [O94911-1]
# Ensembl	ENST00000586539	ENSP00000467271; ENSG00000141338. [O94911-3]
# ExpressionAtlas	O94911	baseline and differential
# FUNCTION	ABCA8_HUMAN	ATP-dependent lipophilic drug transporter. {ECO 0000269|PubMed 12379217}. 
# GO_component	GO:0005743	mitochondrial inner membrane; IBA:GO_Central.
# GO_component	GO:0005886	plasma membrane; TAS:Reactome.
# GO_component	GO:0016021	integral component of membrane; IEA:UniProtKB-KW.
# GO_function	GO:0005524	ATP binding; IEA:UniProtKB-KW.
# GO_function	GO:0008559	xenobiotic-transporting ATPase activity; TAS:Reactome.
# GO_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances; IDA:MGI.
# GO_process	GO:0006810	transport; IDA:MGI.
# GO_process	GO:0006869	lipid transport; IBA:GO_Central.
# GO_process	GO:0055085	transmembrane transport; TAS:Reactome.
# GOslim_component	GO:0005575	cellular_component
# GOslim_component	GO:0005886	plasma membrane
# GOslim_function	GO:0016887	ATPase activity
# GOslim_function	GO:0022857	transmembrane transporter activity
# GOslim_function	GO:0043167	ion binding
# GOslim_process	GO:0006810	transport
# GOslim_process	GO:0055085	transmembrane transport
# Gene3D	3.40.50.300	-; 3.
# Genevisible	O94911	HS
# HGNC	HGNC:38	ABCA8
# InterPro	IPR003439	ABC_transporter-like
# InterPro	IPR003593	AAA+_ATPase
# InterPro	IPR026082	ABC_A
# InterPro	IPR027417	P-loop_NTPase
# KEGG_Brite	ko00001	KEGG Orthology (KO)
# KEGG_Brite	ko02000	 Transporters
# KEGG_Pathway	ko02010	ABC transporters
# MIM	612505	gene
# Organism	ABCA8_HUMAN	Homo sapiens (Human)
# PANTHER	PTHR19229	PTHR19229
# PROSITE	PS50893	ABC_TRANSPORTER_2; 2
# Pfam	PF00005	ABC_tran; 2
# Proteomes	UP000005640	Chromosome 17
# Reactome	R-HSA-382556	ABC-family proteins mediated transport
# RecName	ABCA8_HUMAN	ATP-binding cassette sub-family A member 8
# RefSeq	NP_001275914	NM_001288985.1. [O94911-3]
# RefSeq	NP_001275915	NM_001288986.1
# RefSeq	NP_009099	NM_007168.3. [O94911-1]
# RefSeq	XP_005256995	XM_005256938.2. [O94911-3]
# SEQUENCE CAUTION	Sequence=BAA74845.2; Type=Erroneous initiation; Evidence={ECO	0000305}; 
# SIMILARITY	Belongs to the ABC transporter superfamily. ABCA family. {ECO	0000305}. 
# SIMILARITY	Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule	PRU00434}. 
# SMART	SM00382	AAA; 2
# SUBCELLULAR LOCATION	ABCA8_HUMAN	Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. 
# SUPFAM	SSF52540	SSF52540; 2
# TCDB	3.A.1.211	the atp-binding cassette (abc) superfamily
# TISSUE SPECIFICITY	Widely expressed with higher expression in heart, skeletal muscle and liver. {ECO:0000269|PubMed	12379217}. 
# UCSC	uc002jhp	human. [O94911-1]
# WEB RESOURCE	ABCA8_HUMAN	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http //abcmutations.hegelab.org/proteinDetails?uniprot_id=O94911";
# eggNOG	COG1131	LUCA
# eggNOG	KOG0059	Eukaryota
BLAST	swissprot:ABCA8_HUMAN	http://rest.g-language.org/emboss/kblast/swissprot:ABCA8_HUMAN
BioCyc	ZFISH:ENSG00000141338-MONOMER	http://biocyc.org/getid?id=ZFISH:ENSG00000141338-MONOMER
COXPRESdb	10351	http://coxpresdb.jp/data/gene/10351.shtml
CleanEx	HS_ABCA8	http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_ABCA8
DOI	10.1007/s100380200041	http://dx.doi.org/10.1007/s100380200041
DOI	10.1016/S0006-291X(02)02389-6	http://dx.doi.org/10.1016/S0006-291X(02)02389-6
DOI	10.1016/j.jprot.2013.11.014	http://dx.doi.org/10.1016/j.jprot.2013.11.014
DOI	10.1021/pr8008012	http://dx.doi.org/10.1021/pr8008012
DOI	10.1038/nature04689	http://dx.doi.org/10.1038/nature04689
DOI	10.1093/dnares/5.6.355	http://dx.doi.org/10.1093/dnares/5.6.355
DOI	10.1101/gr.2596504	http://dx.doi.org/10.1101/gr.2596504
EMBL	AB020629	http://www.ebi.ac.uk/ena/data/view/AB020629
EMBL	AC005922	http://www.ebi.ac.uk/ena/data/view/AC005922
EMBL	AC015844	http://www.ebi.ac.uk/ena/data/view/AC015844
EMBL	BC024003	http://www.ebi.ac.uk/ena/data/view/BC024003
EMBL	BC047765	http://www.ebi.ac.uk/ena/data/view/BC047765
EMBL	BC094689	http://www.ebi.ac.uk/ena/data/view/BC094689
EMBL	BC130280	http://www.ebi.ac.uk/ena/data/view/BC130280
Ensembl	ENST00000269080	http://www.ensembl.org/id/ENST00000269080
Ensembl	ENST00000586539	http://www.ensembl.org/id/ENST00000586539
G-Links	9606	http://link.g-language.org/9606/format=tsv
GO_component	GO:0005743	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005743
GO_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_component	GO:0016021	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021
GO_function	GO:0005524	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_function	GO:0008559	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008559
GO_function	GO:0042626	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626
GO_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GO_process	GO:0006869	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006869
GO_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
GOslim_component	GO:0005575	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_component	GO:0005886	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_function	GO:0016887	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_function	GO:0022857	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857
GOslim_function	GO:0043167	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_process	GO:0006810	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810
GOslim_process	GO:0055085	http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085
Gene3D	3.40.50.300	http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneCards	ABCA8	http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ABCA8
GeneID	10351	http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10351
GeneTree	ENSGT00760000118965	http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00760000118965
H-InvDB	HIX0014119	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0014119
H-InvDB	HIX0173681	http://h-invitational.jp/hinv/spsoup/locus_view?hix_id=HIX0173681
HGNC	HGNC:38	http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:38
HOGENOM	HOG000231057	http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231057&db=HOGENOM6
HOVERGEN	HBG079884	http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG079884&db=HOVERGEN
HPA	HPA044914	http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA044914
InParanoid	O94911	http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O94911
InterPro	IPR003439	http://www.ebi.ac.uk/interpro/entry/IPR003439
InterPro	IPR003593	http://www.ebi.ac.uk/interpro/entry/IPR003593
InterPro	IPR026082	http://www.ebi.ac.uk/interpro/entry/IPR026082
InterPro	IPR027417	http://www.ebi.ac.uk/interpro/entry/IPR027417
Jabion	10351	http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=10351
KEGG_Brite	ko00001	http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Brite	ko02000	http://www.genome.jp/dbget-bin/www_bget?ko02000
KEGG_Gene	hsa:10351	http://www.genome.jp/dbget-bin/www_bget?hsa:10351
KEGG_Orthology	KO:K05650	http://www.genome.jp/dbget-bin/www_bget?KO:K05650
KEGG_Pathway	ko02010	http://www.genome.jp/kegg-bin/show_pathway?ko02010
MIM	612505	http://www.ncbi.nlm.nih.gov/omim/612505
OMA	FTANYPE	http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FTANYPE
OrthoDB	EOG091G00AG	http://cegg.unige.ch/orthodb/results?searchtext=EOG091G00AG
PANTHER	PTHR19229	http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19229
PROSITE	PS50893	http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893
PSORT	swissprot:ABCA8_HUMAN	http://rest.g-language.org/emboss/kpsort/swissprot:ABCA8_HUMAN
PSORT-B	swissprot:ABCA8_HUMAN	http://rest.g-language.org/emboss/kpsortb/swissprot:ABCA8_HUMAN
PSORT2	swissprot:ABCA8_HUMAN	http://rest.g-language.org/emboss/kpsort2/swissprot:ABCA8_HUMAN
Pfam	PF00005	http://pfam.xfam.org/family/PF00005
PharmGKB	PA24383	http://www.pharmgkb.org/do/serve?objId=PA24383&objCls=Gene
Phobius	swissprot:ABCA8_HUMAN	http://rest.g-language.org/emboss/kphobius/swissprot:ABCA8_HUMAN
PhylomeDB	O94911	http://phylomedb.org/?seqid=O94911
ProteinModelPortal	O94911	http://www.proteinmodelportal.org/query/uniprot/O94911
PubMed	10048485	http://www.ncbi.nlm.nih.gov/pubmed/10048485
PubMed	12111378	http://www.ncbi.nlm.nih.gov/pubmed/12111378
PubMed	12379217	http://www.ncbi.nlm.nih.gov/pubmed/12379217
PubMed	15489334	http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed	16625196	http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed	19159218	http://www.ncbi.nlm.nih.gov/pubmed/19159218
PubMed	24275569	http://www.ncbi.nlm.nih.gov/pubmed/24275569
Reactome	R-HSA-382556	http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-382556
RefSeq	NP_001275914	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001275914
RefSeq	NP_001275915	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001275915
RefSeq	NP_009099	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_009099
RefSeq	XP_005256995	http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_005256995
SMART	SM00382	http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
STRING	9606.ENSP00000269080	http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000269080&targetmode=cogs
SUPFAM	SSF52540	http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TCDB	3.A.1.211	http://www.tcdb.org/search/result.php?tc=3.A.1.211
UCSC	uc002jhp	http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002jhp&org=rat
UniGene	Hs.58351	http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.58351
UniProtKB	ABCA8_HUMAN	http://www.uniprot.org/uniprot/ABCA8_HUMAN
UniProtKB-AC	O94911	http://www.uniprot.org/uniprot/O94911
charge	swissprot:ABCA8_HUMAN	http://rest.g-language.org/emboss/charge/swissprot:ABCA8_HUMAN
eggNOG	COG1131	http://eggnogapi.embl.de/nog_data/html/tree/COG1131
eggNOG	KOG0059	http://eggnogapi.embl.de/nog_data/html/tree/KOG0059
epestfind	swissprot:ABCA8_HUMAN	http://rest.g-language.org/emboss/epestfind/swissprot:ABCA8_HUMAN
garnier	swissprot:ABCA8_HUMAN	http://rest.g-language.org/emboss/garnier/swissprot:ABCA8_HUMAN
helixturnhelix	swissprot:ABCA8_HUMAN	http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABCA8_HUMAN
hmoment	swissprot:ABCA8_HUMAN	http://rest.g-language.org/emboss/hmoment/swissprot:ABCA8_HUMAN
iep	swissprot:ABCA8_HUMAN	http://rest.g-language.org/emboss/iep/swissprot:ABCA8_HUMAN
inforesidue	swissprot:ABCA8_HUMAN	http://rest.g-language.org/emboss/inforesidue/swissprot:ABCA8_HUMAN
neXtProt	NX_O94911	http://www.nextprot.org/db/entry/NX_O94911
octanol	swissprot:ABCA8_HUMAN	http://rest.g-language.org/emboss/octanol/swissprot:ABCA8_HUMAN
pepcoil	swissprot:ABCA8_HUMAN	http://rest.g-language.org/emboss/pepcoil/swissprot:ABCA8_HUMAN
pepdigest	swissprot:ABCA8_HUMAN	http://rest.g-language.org/emboss/pepdigest/swissprot:ABCA8_HUMAN
pepinfo	swissprot:ABCA8_HUMAN	http://rest.g-language.org/emboss/pepinfo/swissprot:ABCA8_HUMAN
pepnet	swissprot:ABCA8_HUMAN	http://rest.g-language.org/emboss/pepnet/swissprot:ABCA8_HUMAN
pepstats	swissprot:ABCA8_HUMAN	http://rest.g-language.org/emboss/pepstats/swissprot:ABCA8_HUMAN
pepwheel	swissprot:ABCA8_HUMAN	http://rest.g-language.org/emboss/pepwheel/swissprot:ABCA8_HUMAN
pepwindow	swissprot:ABCA8_HUMAN	http://rest.g-language.org/emboss/pepwindow/swissprot:ABCA8_HUMAN
sigcleave	swissprot:ABCA8_HUMAN	http://rest.g-language.org/emboss/sigcleave/swissprot:ABCA8_HUMAN